# EDGAR Filing Document

**Accession Number:** 0001648257
**File Stem:** 0001410578-25-001583
**Filing Date:** 2025-8
**Character Count:** 194968
**Document Hash:** ab517e7111d24f91574b3fcb1efe13a2
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001410578-25-001583.hdr.sgml**: 20250807

**ACCESSION NUMBER**: 0001410578-25-001583

**CONFORMED SUBMISSION TYPE**: 6-K

**PUBLIC DOCUMENT COUNT**: 112

**CONFORMED PERIOD OF REPORT**: 20250630

**FILED AS OF DATE**: 20250807

**DATE AS OF CHANGE**: 20250807

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** HUTCHMED (China) Ltd
- **CENTRAL INDEX KEY:** 0001648257
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** E9

**FILING VALUES:**
- **FORM TYPE:** 6-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-37710
- **FILM NUMBER:** 251191575

**BUSINESS ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** 48TH FLOOR, CHEUNG KONG CENTER
- **STREET 2:** 2 QUEEN'S ROAD CENTRAL
- **CITY:** HONG KONG
- **PROVINCE COUNTRY:** K3
- **BUSINESS PHONE:** 852-2121-3888

**MAIL ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** 48TH FLOOR, CHEUNG KONG CENTER
- **STREET 2:** 2 QUEEN'S ROAD CENTRAL
- **CITY:** HONG KONG
- **PROVINCE COUNTRY:** K3

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Hutchison China MediTech Ltd
- **DATE OF NAME CHANGE:** 20150716

?xml version='1.0' encoding='ASCII'? HUTCHMED (CHINA) LIMITED_2025-06-30

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**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**FORM 6-K**

**REPORT OF FOREIGN PRIVATE ISSUER**

**PURSUANT TO RULE 13a-16 OR 15d-16 UNDER**

**THE SECURITIES EXCHANGE ACT OF 1934**

**For the Month of** **August 2025**

**Commission File Number: 001-37710**

**HUTCHMED (CHINA) LIMITED**

(Translation of registrant's name into English)

**48th Floor, Cheung Kong Center, 2 Queen's Road Central, Hong Kong**

(Address of principal executive offices)

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F:

Form 20-F ⌧ Form 40-F ☐

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#### HUTCHMED (CHINA) LIMITED
**Form 6-K**

#### EXHIBIT INDEX

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| | |
|:---|:---|
| **Exhibit No.** | **Description** |
| [Exhibit 99.1](hcm-20250807xex99d1.htm) | [Announcement relating to unaudited financial results as of and for the six months ended June 30, 2025](hcm-20250807xex99d1.htm) |
| [Exhibit 99.2](hcm-20250807xex99d2.htm) | [HUTCHMED (China) Limited supplemental disclosures](hcm-20250807xex99d2.htm) |

---

#### SIGNATURE
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

---

| | | |
|:---|:---|:---|
| HUTCHMED (CHINA) LIMITED | HUTCHMED (CHINA) LIMITED | HUTCHMED (CHINA) LIMITED |
| By: | /s/ JOHNNY CHENG | /s/ JOHNNY CHENG |
|  | Name: | Johnny Cheng |
|  | Title: | Chief Financial Officer |

---

Date: August 7, 2025

## Exhibit 99.1

?xml version='1.0' encoding='ASCII'? HUTCHMED (CHINA) LIMITED_2025-06-30

**Exhibit 99.1**

![Graphic](hcm-20250807xex99d1001.gif)

**HUTCHMED Reports 2025 Interim Results**

*— Indications expansion driving growth and ATTC platform enriching pipeline —*

*— $455 million in net income attributable to HUTCHMED driven by non-core partial disposal —*

**Hong Kong, Shanghai & Florham Park, NJ — Thursday, August 7, 2025:** HUTCHMED (China) Limited ("HUTCHMED", the "Company" or "we") (Nasdaq/AIM:HCM; HKEX:13) today reports its financial results for the six months ended June 30, 2025 and provides updates on key clinical and commercial developments.

***HUTCHMED to host results webcasts*** *today at 8:00 a.m. EDT / 1:00 p.m. BST / 8:00 p.m. HKT* ***in English on Thursday****, August 7, 2025, and tomorrow at 8:30 a.m. HKT* ***in Chinese (Putonghua) on Friday****, August 8, 2025. After registration, investors may access the live webcast at www.hutch-med.com/event.*

*All amounts are expressed in US dollars unless otherwise stated. A list of abbreviations is in the Glossary on page 36.*

***Global commercial progress and delivery of sustainable growth***

&nbsp;&nbsp;&nbsp;&nbsp;● **ORPATHYS** <sup>®</sup> **(savolitinib) secured China approval** of its third lung cancer indication for EGFRm NSCLC patients with MET amplification after progression on EGFR inhibitor treatment in combination with TAGRISSO <sup>®</sup> (osimertinib) on June 30, 2025, in time to be eligible for potential national reimbursement negotiation towards the end of this year. This combination offers the only oral, chemotherapy-free approach to a sizable percentage (~30%) of these patients. The approval triggered a $11.0 million milestone payment from AstraZeneca which markets both ORPATHYS <sup>®</sup> and TAGRISSO <sup>®</sup> .

&nbsp;&nbsp;&nbsp;&nbsp;● **FRUZAQLA** <sup>®</sup> **(fruquintinib ex-China) in-market sales by Takeda were up 25% to $162.8 million** (H1-24: $130.5m) as its geographical coverage expanded to more than 30 countries. **ELUNATE** <sup>®</sup> **(fruquintinib China) achieved $43.0 million** (H1-24: $61.0m) reflecting intensifying competitive pressures and streamlining of our salesforce structure, but growth has returned recently. Total Oncology/Immunology consolidated revenue, including milestone and service income, was $143.5 million (H1-24: $168.7m).

&nbsp;&nbsp;&nbsp;&nbsp;● **Net income attributable to HUTCHMED of $45 5 . 0 million** was achieved in the first half of 2025 (H1-24: $25.8m), with a **cash balance of $1.36 billion** as of June 30, 2025, significantly boosted by a $416.3 million divestment gain, net of tax from the disposal of a partial equity stake in a non-core joint venture and divestment proceeds.

***Pipeline progress and new technology platform***

&nbsp;&nbsp;&nbsp;&nbsp;● **Positive results from the SACHI China and SAVANNAH global lung cancer trials of ORPATHYS** <sup>®</sup> in combination with TAGRISSO <sup>®</sup> were presented at ASCO and ELCC conferences. SACHI showed mPFS of 8.2 months with this oral combination compared to 3.0 months with chemotherapy, and SAVANNAH showed 7.4 months with this oral combination. This is the only treatment option that demonstrated statistically significant results in a biomarker-directed pivotal clinical trial in MET amplified, EGFR TKI refractory NSCLC patients. Enrollment in the **SAFFRON** global Phase III trial is expected to complete in the second half of this year and **readout in the first half of 2026**.

&nbsp;&nbsp;&nbsp;&nbsp;● **Phase II/III trial on SULANDA** <sup>®</sup> (surufatinib) in combination with AiRuiKa <sup>®</sup> (camrelizumab) and chemotherapy for previously-untreated metastatic pancreatic cancer patients is progressing well, targeting data readout in the second half of 2025. An earlier study presented promising updated data at ASCO with ORR of 51.1% (vs 24.4% with chemotherapy) and mPFS of 7.9 months (vs 5.4 months).

&nbsp;&nbsp;&nbsp;&nbsp;● **Positive FRUSICA-2 Phase III results supported the China approval submission for ELUNATE** <sup>®</sup> with TYVYT <sup>®</sup> (sintilimab) in previously-treated kidney cancer. Details to be presented at ESMO Congress. Prior Phase Ib/II study showed ORR of 60.0% and mPFS of 15.9 months.

&nbsp;&nbsp;&nbsp;&nbsp;● **New Antibody-Targeted Therapy Conjugates (ATTC) platform** drug candidates have been selected, planning to enter clinical development in late 2025. We also plan to present pre-clinical data at a scientific conference before the end of this year. Successful development of multiple ATTC molecules is expected to lead to collaboration and licensing opportunities in the future. Initial responses from potential partners are very positive.

**Dr Dan Eldar, Non-executive Chairman of HUTCHMED, said,** "With a strong balance sheet, robust operations and an exciting new ATTC platform, HUTCHMED is ready to enter a new phase of growth. Partnering is still a strategic focus, with multinational pharmaceutical companies remaining favorable towards such licensing opportunities with China biotech companies. In recent months we have seen markets' sentiment and performance have significantly improved. China domestic drug policy and pricing environment also manifest strengthened support for innovative drug development, with the potential introduction of a commercial insurance drug list later this year, targeting a diversified, multi-layered healthcare social security payment system down the road.

We intend to prudently and actively deploy resources to expedite the development of a series of drug candidates from our novel ATTC platform, including synchronous clinical development in China and overseas. Our 20 years of knowledge of in-house discovery, experience in running large-scale pivotal trials, collaboration with international partners and success in obtaining global regulatory approvals empower us to bring forth more innovative medicines to address large unmet needs around the world."

**Dr Weiguo Su, Chief Executive Officer and Chief Scientific Officer of HUTCHMED, said,** "We concluded the first half of 2025 with several important milestones achieved, some earlier than expected. The presentation of SACHI data at ASCO in a late-breaking oral presentation at the beginning of June was impressive, validating both the clinical strength and commercial advantages of **ORPATHYS**<sup>®</sup> in the market. This is the first biomarker-selected pivotal study globally for EGFR TKI refractory lung cancer patients, demonstrating clear clinical benefits for these patients. The China approval of ORPATHYS<sup>®</sup> at the end of June for this indication, six months after filing acceptance, was ahead of schedule and in time to qualify for national reimbursement negotiation. Also in June, the third indication of **ELUNATE**<sup>®</sup> for kidney cancer was accepted for review by the NMPA, supported by positive data in the FRUSICA-2 Phase III trial, to be presented at ESMO Congress. We also launched **TAZVERIK**<sup>®</sup> **(tazemetostat),** our first hematological oncology drug, in July following approval in March.

We believe sales growth should improve in second half of 2025, with the help of indication expansion in China and better market penetration overseas. In the near term, we shall start clinical development of multiple drug candidates from our ATTC program, a crucial technology platform, which will enrich our pipeline and provide ample partnership opportunities."

**2025 INTERIM RESULTS & BUSINESS UPDATES**

**I. COMMERCIAL OPERATIONS**

**FRUZAQLA**<sup>®</sup> **in-market sales by Takeda were up 25% in the first half of 2025** at $162.8 million, driven by strong growth following approvals in more than 30 countries to date, including over 10 new markets in 2025. Reimbursement was received in the US, Spain and Japan last year, and in July 2025, positive recommendation was received for NHS reimbursement in England and Wales.

The China pharmaceutical sector has gone through multifaceted changes. To position HUTCHMED for sustainable long-term growth, HUTCHMED has streamlined its sales force to establish a more efficient commercial organization and enhance productivity. In the face of intensifying competition as its products mature, HUTCHMED has strengthened its strategy to continue to focus on science-driven commercial activities to further differentiate its products. In the first half of 2025, in-market sales in China for ELUNATE<sup>®</sup>, SULANDA<sup>®</sup> and ORPATHYS<sup>®</sup> decreased as compared to the first half of 2024, reflecting competition and the transitional effects of the changes in our sales team and marketing strategy.

Total in-market sales were down 4%. Consolidated revenue dropped 22% due to lower China in-market sales, offset by flat FRUZAQLA<sup>®</sup> revenue.

Other Oncology/Immunology revenue, consisting of upfront or milestones, R&D services and licensing to our partners increased 9% to $44.4 million. Revenue from Other Ventures, comprising prescription drug distribution, remained flat, leading to **total consolidated revenue of $277.7 million, down 9%**.

---

| | | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
|  | **In-market Sales\*** | **In-market Sales\*** | **In-market Sales\*** | **In-market Sales\*** | **In-market Sales\*** | **Consolidated Revenue\*\*** | **Consolidated Revenue\*\*** | **Consolidated Revenue\*\*** | **Consolidated Revenue\*\*** | **Consolidated Revenue\*\*** |
| *(Unaudited, $ in millions)* | **H1 2025** | **H1 2024** |  | ***%Δ*** | ***(CER)*** | **H1 2025** | **H1 2024** |  | ***%Δ*** | ***(CER)*** |
| FRUZAQLA<sup>®</sup> | $162.8 | $130.5 |  | *+25%* | *(+25%)* | $43.1 | $42.8 |  | *+1%* | *(+1%)* |
| ELUNATE<sup>®</sup> | $43.0 | $61.0 |  | *-29%* | *(-29%)* | $33.6 | $46.0 |  | *-27%* | *(-27%)* |
| SULANDA<sup>®</sup> | $12.7 | $25.4 |  | *-50%* | *(-50%)* | $12.7 | $25.4 |  | *-50%* | *(-50%)* |
| ORPATHYS<sup>®</sup> | $15.2 | $25.9 |  | *-41%* | *(-41%)* | $9.0 | $13.1 |  | *-32%* | *(-32%)* |
| TAZVERIK<sup>®</sup> | $0.7 | $0.5 |  | *+49%* | *(+49%)* | $0.7 | $0.5 |  | *+49%* | *(+49%)* |
| &nbsp;&nbsp;**Oncology Products** | $**234.4** | $**243.3** |  | ***-4%*** | ***(-4%)*** | $**99.1** | $**127.8** |  | ***-22%*** | ***(-22%)*** |
| Takeda upfront, regulatory milestones and R&D services | Takeda upfront, regulatory milestones and R&D services | Takeda upfront, regulatory milestones and R&D services | Takeda upfront, regulatory milestones and R&D services | Takeda upfront, regulatory milestones and R&D services | Takeda upfront, regulatory milestones and R&D services | $29.5 | $33.8 |  | *-13%* | *(-13%)* |
| Other revenue (R&D services and licensing) | Other revenue (R&D services and licensing) | Other revenue (R&D services and licensing) | Other revenue (R&D services and licensing) | Other revenue (R&D services and licensing) | Other revenue (R&D services and licensing) | $14.9 | $7.1 |  | *+111%* | *(+111%)* |
| &nbsp;&nbsp;**Total Oncology/Immunology** |  |  |  |  |  | $**143.5** | $**168.7** |  | ***-15%*** | ***(-15%)*** |
| Other Ventures |  |  |  |  |  | $134.2 | $137.0 |  | *-2%* | *(-1%)* |
| &nbsp;&nbsp;**Total Revenue** |  |  |  |  |  | $**277.7** | $**305.7** |  | ***-9%*** | ***(-9%)*** |

---

*\* FRUZAQLA*<sup>®</sup>*, ELUNATE*<sup>®</sup> *and ORPATHYS*<sup>®</sup> *mainly represent total sales to third parties as provided by Takeda, Eli Lilly and AstraZeneca, respectively.*

*\*\* FRUZAQLA*<sup>®</sup> *represents manufacturing revenue and royalties paid by Takeda; ELUNATE*<sup>®</sup> *represents manufacturing revenue, promotion and marketing services revenue and royalties paid by Eli Lilly to HUTCHMED, and sales to other third parties invoiced by HUTCHMED; ORPATHYS*<sup>®</sup> *represents manufacturing revenue and royalties paid by AstraZeneca to HUTCHMED and sales to other third parties invoiced by HUTCHMED; SULANDA*<sup>®</sup> *and TAZVERIK*<sup>®</sup> *represent the HUTCHMED's sales of the products to third parties.*

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

**II. REGULATORY UPDATES**

&nbsp;&nbsp;&nbsp;&nbsp;● **Savolitinib sNDA approved by the NMPA** for 2L EGFRm NSCLC patients with MET amplification, in combination with TAGRISSO <sup>®</sup> , triggering $11.0 million milestone from AstraZeneca, in June 2025.

&nbsp;&nbsp;&nbsp;&nbsp;● **Savolitinib sNDA approved by the NMPA** for 1L and 2L (converted from conditional to full approval) METex14 NSCLC in January 2025. **Savolitinib approved in Hong Kong** for METex14 NSCLC under the 1+ Mechanism in February 2025.

&nbsp;&nbsp;&nbsp;&nbsp;● **Tazemetostat NDA conditionally approved by the NMPA** for 3L R/R follicular lymphoma with EZH2 mutation in March 2025.

**III. LATE-STAGE CLINICAL DEVELOPMENT ACTIVITIES**

***Savolitinib (ORPATHYS***<sup>®</sup> ***in China)****, a highly selective oral inhibitor of MET*

&nbsp;&nbsp;&nbsp;&nbsp;● **Presented SACHI China Phase III** results at ASCO 2025 for 2L EGFRm NSCLC patients with MET amplification, in combination with TAGRISSO <sup>®</sup> , showing mPFS of 8.2 months compared to 4.5 months with chemotherapy in ITT population (HR 0.34), and 6.9 months compared to 3.0 months in post third-generation EGFR TKI-treated subgroup (HR 0.32, both p<0.0001) (NCT05015608).

&nbsp;&nbsp;&nbsp;&nbsp;● **Presented SAVANNAH global Phase II** results at ELCC 2025 for 2L EGFRm NSCLC patients with MET amplification or overexpression, in combination with TAGRISSO <sup>®</sup> , showing ORR of 56%, mPFS of 7.4 months and mDoR of 7.1 months (NCT03778229).

&nbsp;&nbsp;&nbsp;&nbsp;● **Continued enrolling SAFFRON** global Phase III study for 2L EGFRm NSCLC patients with MET amplification or overexpression (NCT05261399) and the study will potentially support global filings; and **SANOVO** China Phase III study for 1L EGFRm NSCLC patients with MET overexpression (NCT05009836).

&nbsp;&nbsp;&nbsp;&nbsp;● **Completed enrollment of China Phase II** registrational study for 3L gastric cancer patients with MET amplification (NCT04923932).

*Potential upcoming clinical milestones for savolitinib:*

&nbsp;&nbsp;&nbsp;&nbsp;● Complete SAFFRON Phase III enrollment in the second half of 2025, data readout in the first half of 2026.

&nbsp;&nbsp;&nbsp;&nbsp;● Complete SANOVO China Phase III enrollment in the second half of 2025.

***Fruquintinib (ELUNATE***<sup>®</sup> ***in China, FRUZAQLA***<sup>®</sup> ***outside of China)****, a selective oral inhibitor of VEGFR*

&nbsp;&nbsp;&nbsp;&nbsp;● **Positive results of FRUSICA-2 China Phase III** in 2L RCC in March 2025 (NCT05522231).

&nbsp;&nbsp;&nbsp;&nbsp;● **Presented China Phase II IIT** results at AACR, in combination with TUOYI <sup>®</sup> (toripalimab) or TYVYT <sup>®</sup> , in 2L and above MSS/pMMR CRC, showing mPFS of 13.2 months and mOS of 29.0 months (NCT04483219).

***Sovleplenib (HMPL-523)****, an investigative and highly selective oral inhibitor of Syk*

&nbsp;&nbsp;&nbsp;&nbsp;● Ongoing ESLIM-01 ITP NMPA NDA review stipulates a lower impurity limit, requiring further manufacturing validation and stability test. Target re-submission in first half of 2026, with additional data rolling in during second half of 2026. In the future, the company will look to continue overseas development.

&nbsp;&nbsp;&nbsp;&nbsp;● **Published China Phase II results** in warm AIHA in China at EHA and in *The Lancet Haematology* in 2025, demonstrating overall response rate of 66.7% and a favorable safety profile (NCT05535933).

&nbsp;&nbsp;&nbsp;&nbsp;● Completed ESLIM-02 China Phase III enrollment for warm AIHA in June 2025 (NCT05535933).

*Potential upcoming regulatory milestones for sovleplenib:*

&nbsp;&nbsp;&nbsp;&nbsp;● ESLIM-01 NMPA NDA re-submission in first half of 2026 (NCT05029635).

&nbsp;&nbsp;&nbsp;&nbsp;● ESLIM-02 NMPA sNDA submission in first half of 2026 (NCT05535933).

***Surufatinib (SULANDA***<sup>®</sup> ***in China)****, an oral inhibitor of VEGFR, FGFR and CSF-1R*

*Potential upcoming clinical milestone for surufatinib:*

&nbsp;&nbsp;&nbsp;&nbsp;● **Data readout of Phase II part of a China Phase II/III** HUTCHMED-sponsored trial for 1L metastatic PDAC patients, in combination with AiRuiKa <sup>®</sup> , nab-paclitaxel and gemcitabine in late 2025 (NCT06361888).

***Tazemetostat (TAZVERIK***<sup>®</sup> ***in China)****, a first-in-class, oral inhibitor of EZH2*

&nbsp;&nbsp;&nbsp;&nbsp;● **TAZVERIK** <sup>®</sup> **NDA approved by the NMPA** for 3L R/R follicular lymphoma with EZH2 mutation.

&nbsp;&nbsp;&nbsp;&nbsp;● **Continued enrolling SYMPHONY-1 China portion of the Phase III** portion of the global study, in combination with lenalidomide and rituximab, in 2L follicular lymphoma patients (NCT04224493).

***Fanregratinib (HMPL-453)****, a novel, highly selective and potent inhibitor targeting FGFR 1, 2 and 3*

&nbsp;&nbsp;&nbsp;&nbsp;● **Completed enrollment of China Phase II** registrational trial for IHCC with FGFR fusion / rearrangement in February 2025 (NCT04353375).

***Ranosidenib (HMPL-306)****, an investigative and highly selective oral dual-inhibitor of IDH1 and IDH2 enzymes*

&nbsp;&nbsp;&nbsp;&nbsp;● **Continued enrolling RAPHAEL China Phase III trial** for 2L R/R IDH1/2-mutant AML (NCT06387069).

**IV. ANTIBODY-TARGETED THERAPY CONJUGATE (ATTC) PLATFORM**

***New in-house created platform with multiple potential IND candidates***

HUTCHMED plans to initiate China and global clinical trials for our first ATTC drug candidate around the end of 2025, followed by multiple global IND filings for more ATTC candidates in 2026.

Our ATTC next-generation technology platform leverages over 20 years of expertise in targeted therapies with small molecules inhibitors. By linking a monoclonal antibody with a **proprietary targeted small-molecule inhibitor (SMI)** payload, our ATTC platform has the capability to derive **multiple drug candidates targeting various oncology indications**, including precision medicine against selective sub-types. These ATTC drug candidates enrich the next wave of clinical development with potential key advantages over traditional antibody-drug conjugates and/or small molecule medicines.

&nbsp;&nbsp;&nbsp;&nbsp;● **Better efficacy** through synergistic antibody-small molecule targeted therapy combinations that will target specific mutations; overcome drug resistance to existing treatment.

&nbsp;&nbsp;&nbsp;&nbsp;● **Improved safety and prolonged treatment** given lower off-tumor or off-target toxicity than small molecules, lower risk of myelosuppression and better safety than cytotoxin-based conjugates.

&nbsp;&nbsp;&nbsp;&nbsp;● **Attractive pharmacokinetics** tackles difficult drug targets, enabled by antibody-guided delivery to target sites which will improve bioavailability and reduce drug-drug interactions.

&nbsp;&nbsp;&nbsp;&nbsp;● **Advantages over existing ADCs** due to lower off-tumor toxicities from the SMI payload, released through lysosomal cleavage inside target cells, targets cell signaling pathway driven by mutation specific to tumor cells. It can be used in combination with established standard therapies such as chemotherapy and immunotherapy to further enhance efficacy.

&nbsp;&nbsp;&nbsp;&nbsp;● **Potential first-line applications,** as chemo-free ATTC can potentially support combinations with other targeted therapies, chemotherapy and immunotherapy, in early-line settings with broad market potential.

**V. COLLABORATION UPDATES**

***Further progress of candidate IMG-007, discovered by HUTCHMED***

&nbsp;&nbsp;&nbsp;&nbsp;● **ImageneBio, Inc. (Nasdaq: IMA) –** Inmagene and Ikena Oncology, Inc. completed a merger on July 25, 2025 and ImageneBio, Inc., the merged entity, holds the license rights to IMG-007 granted by HUTCHMED. HUTCHMED has an approximate 3.67% shareholding in ImageneBio, Inc.

&nbsp;&nbsp;&nbsp;&nbsp;● **Announced positive results of a US/Canada Phase IIa** study of IMG-007 for atopic dermatitis in April 2025 **,** showing week 16 mean change in EASI of 77% and EASI-75 response of 54% (NCT05984784).

&nbsp;&nbsp;&nbsp;&nbsp;● **Dosed the first patient in a US Phase IIb** randomized, double-blind, placebo-controlled dose-finding study of IMG-007 for moderate-to-severe atopic dermatitis in July 2025, targeting to enroll 220 patients who have had inadequate response to and/or intolerance of topical therapies (NCT07037901).

&nbsp;&nbsp;&nbsp;&nbsp;● **Announced positive results of a US/Canada Phase IIa** study of IMG-007 for severe alopecia areata in January 2025, showing mean reduction from baseline in *Severity of Alopecia Tool* (SALT) score of 30.1% by week 36 (NCT06060977).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

**VI. OTHER VENTURES**

&nbsp;&nbsp;&nbsp;&nbsp;● Other Ventures consolidated revenue, predominantly from the prescription drug distribution business in China, were steady at $134.2 million for the six months ended June 30, 2025.

&nbsp;&nbsp;&nbsp;&nbsp;● HUTCHMED divested a 45.0% equity interest in SHPL for $608.5 million in cash in April 2025, retaining a 5.0% equity interest. A divestment gain, net of tax of $416.3 million was recognized during the first half of 2025. As a result, HUTCHMED ' s share of equity in earnings of SHPL decreased to $23.1 million for the six months ended June 30, 2025.

&nbsp;&nbsp;&nbsp;&nbsp;● Consolidated net income attributable to HUTCHMED from Other Ventures increased to $440.3 million (H1-24: $34.1m), primarily due to the SHPL interest disposal.

**VII. SUSTAINABILITY**

In April 2025, the 2024 Sustainability Report was published, highlighting the progress made in 11 goals and targets and enhanced climate actions, including improved Scope 3 data, tightened control over air travel and engagement with suppliers. This year, a comprehensive climate risks assessment is being conducted to further understand and quantify the potential financial impacts of climate change, including physical risks brought by flooding and heat stress, and transition risks for HUTCHMED under optimistic and pessimistic scenarios.

HUTCHMED has made notable progress in its ESG ratings, including ratings from CDP Worldwide, the Hang Seng Corporate Sustainability Index Series, ISS ESG, MSCI ESG, Sustainalytics, and S&P Global ESG. In May 2025, HUTCHMED ranked third in ESG Excellence in the Healthcare, Pharmaceutical, and Biotechnology sector in the Extel's Asia Executive Team survey, reflecting feedback from over 5,400 portfolio managers and analysts. Extel ranked HUTCHMED as one of the Most Honored Companies; ranked it first in Best Board of Directors, Best CEO, Best IR Program and Best IR Professionals; as well as second in Best CFO and Best IR Team in the Healthcare, Pharmaceutical, and Biotechnology sector.

**FINANCIAL HIGHLIGHTS**

***Revenue for the six months ended June 30, 2025 was $277.7 million compared to $305.7 million for the six months ended June 30, 2024.***

&nbsp;&nbsp;&nbsp;&nbsp;● **Oncology/Immunology consolidated revenue amounted to $143.5 million** (H1-24: $168.7m):

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|:---|:---|
| ◾ | **FRUZAQLA**<sup>®</sup> revenue was $43.1 million (H1-24: $42.8m), reflecting continued growth in royalties, offset by reduced manufacturing revenue compared to its launch year. In-market sales by Takeda were $162.8 million (up 25%) driven by strong growth following approvals in more than 30 countries to date, including over 10 new markets in 2025. |

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| ◾ | **ELUNATE**<sup>®</sup> **revenue decreased to $33.6 million** (H1-24: $46.0m) in its seventh year since launch, comprising manufacturing revenue, promotion and marketing services revenue and royalties. In-market sales decreased to $43.0 million, reflecting the intensifying competitive pressures from combination therapies of key competing products and their additional generics and biosimilars entry in 3L CRC. The launch of the entry of the new indication 2L EMC in 2025 and continuous inclusion of ELUNATE<sup>®</sup> in key guidelines are expected to drive future growth. |

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| ◾ | **SULANDA**<sup>®</sup> **revenue decreased to $12.7 million** (H1-24: $25.4m) in the face of strong competition for NET patients from new somatostatin analogues drugs with their inclusion in the NRDL and broader coverage. To counteract this challenge, we continue to drive awareness and product differentiation to uphold SULANDA<sup>®</sup> position in TKI. |

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|:---|:---|
| ◾ | **ORPATHYS**<sup>®</sup> **revenue decreased to $9.0 million** (H1-24: $13.1m) on in-market sales of $15.2 million, impacted by the launch and NRDL inclusion of several competing drugs for METex14 skipping NSCLC. Such results have not reflected expected growth from the recent approval for the much larger EGFR TKI-refractory, MET-amplified NSCLC patient population at the end of June 2025. |

---

---

| | |
|:---|:---|
| ◾ | **TAZVERIK**<sup>®</sup> **revenue was $0.7 million** (H1-24: $0.5m) mainly from sales in Hainan and Hong Kong. Launched in mainland China in July 2025 following its approval in March 2025. |

---

---

| | |
|:---|:---|
| ◾ | **Takeda upfront, regulatory milestones and R&D services revenue were $29.5 million** (H1-24: $33.8m), of which $26.6 million was recognized from Takeda deferred revenue. |

---

---

| | |
|:---|:---|
| ◾ | **Other revenue of $14.9 million** (H1-24: $7.1m), includes regulatory milestone of $11.0 million from AstraZeneca following China NDA approval for ORPATHYS<sup>®</sup> combined with TAGRISSO<sup>®</sup>. |

---

&nbsp;&nbsp;&nbsp;&nbsp;● **Other Ventures consolidated revenue of $134.2 million** (H1-24: $137.0m) remained flat.

***Net Expenses for the six months ended June 30, 2025 were $239.0 million compared to $279.9 million for the six months ended June 30, 2024, reflecting strong cost control efforts.***

&nbsp;&nbsp;&nbsp;&nbsp;● **Cost of Revenue** decreased 7% to $167.6 million (H1-24: $180.1m), which was mainly due to lower Oncology/Immunology revenue. Cost of revenue as a percentage of oncology product revenue remained stable at 39% (H1-24: 38%).

&nbsp;&nbsp;&nbsp;&nbsp;● **R&D Expenses** reduced by 24% to $72.0 million (H1-24: $95.3m). While R&D investment outside of China reduced to $7.6 million (H1-24: $14.9m) as we continued to integrate our global R&D operations with China, the decrease was mainly driven by China with R&D investment of $64.4 million (H1-24: $80.4m) reflecting lower costs from completed studies which are under NDA review (e.g. ELUNATE <sup>®</sup> in 2L RCC) or already led to NMPA approval in H1-25 (e.g. ORPATHYS <sup>®</sup> in 2L NSCLC). Joint China and global clinical development effort ongoing to gear up for multiple drug candidates from our ATTC program.

&nbsp;&nbsp;&nbsp;&nbsp;● **S&A Expenses** were $41.6 million (H1-24: $57.8m). The decrease was mainly due to a reduction in S&A expenses for oncology products which was $13.4 million or 13.5% of oncology product revenue (H1-24: $25.1 million or 19.6%) as sales force structure was streamlined and tighter spending controls imposed.

&nbsp;&nbsp;&nbsp;&nbsp;● **Other Items** generated net income of $42.2 million (H1-24: $53.3m), mainly comprised of equity in earnings of SHPL, interest income and expense, foreign exchange and taxes. The decrease was primarily due to lower share of equity in earnings of SHPL at $23.1 million (H1-24: $33.8m) as our share decreased to 5% (H1-24: 50%) after the divestment of a partial stake in SHPL completed in April 2025.

***Gain on divestment of SHPL, net of tax was $416.3 million for the six months ended June 30, 2025.***

***Net Income attributable to HUTCHMED for the six months ended June 30, 2025 was $455.0 million compared to $25.8 million for the six months ended June 30, 2024.***

&nbsp;&nbsp;&nbsp;&nbsp;● The net income attributable to HUTCHMED for the six months ended June 30, 2025 was $0. 53 per ordinary share / $2.65 per ADS (H1-24: $0. 03 per ordinary share / $0. 15 per ADS).

***Cash, Cash Equivalents and Short-Term Investments were $1,364.5 million as of June 30, 2025 compared to $836.1 million as of December 31, 2024.***

&nbsp;&nbsp;&nbsp;&nbsp;● Adjusted Group (non-GAAP) net cash inflows excluding financing activities in the first half of 2025 were $519.1 million mainly due to the receipt of $608.5 million gross proceeds from the partial divestment of SHPL, offset with the $59.5 million capital gain tax payment for the partial divestment of SHPL, $10.0 million regulatory approval milestone payment and $9.2 million in capital expenditures (H1-24: -$51.3m mainly due to $39.8 million net cash used in operating activities and $10.1 million of capital expenditures).

&nbsp;&nbsp;&nbsp;&nbsp;● Net cash generated from financing activities in the first half of 2025 totaled $9.3 million mainly due to drawdowns of bank borrowings of $8.2 million (H1-24: net cash used in financing activities of $32.6m mainly due to purchases for equity awards of $36.1 million).

**Foreign exchange impact:** The RMB depreciated against the US dollar on average by approximately 0.8% during the first half of 2025, which has impacted consolidated financial results as highlighted.

**FINANCIAL GUIDANCE**

HUTCHMED updates full year 2025 guidance for Oncology/Immunology consolidated revenue to $270 million - $350 million due to the phasing of milestone income from partners to 2026 and onwards, as well as the estimated delay of sovleplenib China NDA review completion to after 2025. HUTCHMED will leverage its strong cash resources to accelerate ATTC global development and explore investment opportunities.

Shareholders and investors should note that:

&nbsp;&nbsp;&nbsp;&nbsp;● The Company does not provide any guarantee that the statements contained in the financial guidance will materialize or that the financial results contained therein will be achieved or are likely to be achieved; and

&nbsp;&nbsp;&nbsp;&nbsp;● The Company has in the past revised its financial guidance and reference should be made to any announcements published by it regarding any updates to the financial guidance after the date of publication of this announcement.

———

***Use of Non-GAAP Financial Measures and Reconciliation*** – References in this announcement to adjusted Group net cash flows excluding financing activities and financial measures reported at CER are based on non-GAAP financial measures. Please see the "Use of Non-GAAP Financial Measures and Reconciliation" for further information relevant to the interpretation of these financial measures and reconciliations of these financial measures to the most comparable GAAP measures, respectively.

———

**FINANCIAL SUMMARY**

**Condensed Consolidated Balance Sheets Data**

---

| | | |
|:---|:---|:---|
|  | **As of**  | **As of**  |
| (in $'000) | **June 30, 2025** | **December 31, 2024** |
|  | (Unaudited) |  |
| **Assets** |  |  |
| &nbsp;&nbsp;Cash and cash equivalents and short-term investments | 1364520 | 836110 |
| &nbsp;&nbsp;Accounts receivable | 146967 | 155537 |
| &nbsp;&nbsp;Other current assets | 80840 | 74908 |
| &nbsp;&nbsp;Property, plant and equipment | 94573 | 92498 |
| &nbsp;&nbsp;Investment in an equity investee | 3645 | 77765 |
| &nbsp;&nbsp;Other non-current assets | 85395 | 37378 |
| **Total assets** | **1775940** | **1274196** |
| **Liabilities and shareholders' equity** |  |  |
| &nbsp;&nbsp;Accounts payable | 43725 | 42521 |
| &nbsp;&nbsp;Other payables, accruals and advance receipts | 221061 | 256124 |
| &nbsp;&nbsp;Deferred revenue | 77628 | 98503 |
| &nbsp;&nbsp;Bank borrowings | 93444 | 82806 |
| &nbsp;&nbsp;Other liabilities | 98159 | 22389 |
| **Total liabilities** | **534017** | **502343** |
| **Company's shareholders' equity** | **1229064** | **759929** |
| Non-controlling interests | 12859 | 11924 |
| **Total liabilities and shareholders' equity** | **1775940** | **1274196** |

---

**Condensed Consolidated Statements of Operations Data**

---

| | | |
|:---|:---|:---|
| (Unaudited, in $'000, except share and per share data) | **Six months ended June 30,** | **Six months ended June 30,** |
|  | **2025** | **2024** |
| **Revenue:** |  |  |
| &nbsp;&nbsp;Oncology/Immunology – Marketed Products | 99039 | 127796 |
| &nbsp;&nbsp;Oncology/Immunology – R&D | 44408 | 40841 |
| &nbsp;&nbsp;&nbsp;&nbsp;Oncology/Immunology Consolidated Revenue | 143447 | 168637 |
| &nbsp;&nbsp;Other Ventures | 134230 | 137044 |
| &nbsp;&nbsp;&nbsp;&nbsp;**Total revenue** | **277677** | **305681** |
| **Operating expenses:** |  |  |
| &nbsp;&nbsp;Cost of revenue | (167577) | (180135) |
| &nbsp;&nbsp;Research and development expenses | (71990) | (95256) |
| &nbsp;&nbsp;Selling and administrative expenses | (41624) | (57811) |
| &nbsp;&nbsp;&nbsp;&nbsp;**Total operating expenses** | **(281191)** | **(333202)** |
|  | **(3514)** | **(27521)** |
| &nbsp;&nbsp;Gain on divestment of an equity investee | 477456 |  |
| &nbsp;&nbsp;Other income, net | 21650 | 22765 |
| **Income/(loss) before income taxes and equity in earnings of an equity investee** | **495592** | **(4756)** |
| &nbsp;&nbsp;Income tax expense | (2029) | (2886) |
| &nbsp;&nbsp;Income tax expense – Divestment of an equity investee | (61133) |  |
| &nbsp;&nbsp;Equity in earnings of an equity investee, net of tax | 23125 | 33807 |
| **Net income** | **455555** | **26165** |
| Less: Net income attributable to non-controlling interests | (601) | (364) |
| **Net income attributable to HUTCHMED** | **454954** | **25801** |
| **Earnings per share attributable to HUTCHMED (US$ per share)** |  |  |
| &nbsp;&nbsp;**– basic** | **0.53** | **0.03** |
| &nbsp;&nbsp;**– diluted** | **0.52** | **0.03** |
| Number of shares used in per share calculation |  |  |
| &nbsp;&nbsp;– basic | 857038725 | 856030704 |
| &nbsp;&nbsp;– diluted | 872564513 | 872534466 |
| **Earnings per ADS attributable to HUTCHMED (US$ per ADS)** |  |  |
| &nbsp;&nbsp;**– basic** | **2.65** | **0.15** |
| &nbsp;&nbsp;**– diluted** | **2.61** | **0.15** |
| Number of ADSs used in per ADS calculation |  |  |
| &nbsp;&nbsp;– basic | 171407745 | 171206141 |
| &nbsp;&nbsp;– diluted | 174512903 | 174506893 |

---

**About HUTCHMED**

HUTCHMED (Nasdaq/AIM:HCM; HKEX:13) is an innovative, commercial-stage, biopharmaceutical company. It is committed to the discovery and global development and commercialization of targeted therapies and immunotherapies for the treatment of cancer and immunological diseases. Since inception it has focused on bringing drug candidates from in-house discovery to patients around the world, with its first three medicines marketed in China, and the first of which is also approved around the world including in the US, Europe and Japan. For more information, please visit: www.hutch-med.com or follow us on LinkedIn.

**Contacts**

---

| | |
|:---|:---|
| **Investor Enquiries** | +852 2121 8200 / ir@hutch-med.com |
| **Media Enquiries** |  |
| FTI Consulting – | +44 20 3727 1030 / HUTCHMED@fticonsulting.com |
| &nbsp;&nbsp;&nbsp;&nbsp;Ben Atwell / Alex Shaw | +44 7771 913 902 (Mobile) / +44 7779 545 055 (Mobile) |
| Brunswick – Zhou Yi | +852 9783 6894 (Mobile) / HUTCHMED@brunswickgroup.com |
| **Panmure Liberum** | *Nominated Advisor and Joint Broker* |
| Atholl Tweedie / Emma Earl / Rupert Dearden | +44 20 7886 2500 |
| **Cavendish** | *Joint Broker* |
| Geoff Nash / Nigel Birks | +44 20 7220 0500 |
| **Deutsche Numis** | *Joint Broker* |
| Freddie Barnfield / Jeffrey Wong / Duncan Monteith | +44 20 7260 1000 |

---

***References***

*Unless the context requires otherwise, references in this announcement to the "Group," the "Company," "HUTCHMED," "HUTCHMED Group," "we," "us," and "our," mean HUTCHMED (China) Limited and its subsidiaries unless otherwise stated or indicated by context.*

***Past Performance and Forward-Looking Statements***

*The performance and results of operations of the Group contained within this announcement are historical in nature, and past performance is no guarantee of future results of the Group. This announcement contains forward-looking statements within the meaning of the "safe harbor" provisions of the US Private Securities Litigation Reform Act of 1995. These forward-looking statements can be identified by words like "will," "expects," "anticipates," "future," "intends," "plans," "believes," "estimates," "pipeline," "could," "potential," "first-in-class," "best-in-class," "designed to," "objective," "guidance," "pursue," or similar terms, or by express or implied discussions regarding potential drug candidates, potential indications for drug candidates or by discussions of strategy, plans, expectations or intentions. You should not place undue reliance on these statements. Such forward-looking statements are based on the current beliefs and expectations of management regarding future events, and are subject to significant known and unknown risks and uncertainties. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those set forth in the forward-looking statements. There can be no guarantee that any of our drug candidates will be approved for sale in any market, that any approvals which have been obtained will continue to remain valid and effective in the future, or that the sales of products marketed or otherwise commercialized by HUTCHMED and/or its collaboration partners (collectively, "HUTCHMED's Products") will achieve any particular revenue or net income levels. In particular, management's expectations could be affected by, among other things: unexpected regulatory actions or delays or government regulation generally; the uncertainties inherent in research and development, including the inability to meet our key study assumptions regarding enrollment rates, timing and availability of subjects meeting a study's inclusion and exclusion criteria and funding requirements, changes to clinical protocols, unexpected adverse events or safety, quality or manufacturing issues; the delay or inability of a drug candidate to meet the primary or secondary endpoint of a study; the delay or inability of a drug candidate to obtain regulatory approval in different jurisdictions or the utilization, market acceptance and commercial success of HUTCHMED's Products after obtaining regulatory approval; discovery, development and/or commercialization of competing products and drug candidates that may be superior to, or more cost effective than, HUTCHMED's Products and drug candidates; the impact of studies (whether conducted by HUTCHMED or others and whether mandated or voluntary) or recommendations and guidelines from governmental authorities and other third parties on the commercial success of HUTCHMED's Products and drug candidates in development; the ability of HUTCHMED to manufacture and manage supply chains, including various third party services, for multiple products and drug candidates; the availability and extent of reimbursement of HUTCHMED's Products from third-party payers, including private payer healthcare and insurance programs and government insurance programs; the costs of developing, producing and selling HUTCHMED's Products; the ability to obtain additional funding when needed; the ability to obtain and maintain protection of intellectual property for HUTCHMED's Products and drug candidates; the ability of HUTCHMED to meet any of its financial projections or guidance and changes to the assumptions underlying those projections or guidance; the successful disposition of its non-core business; global trends toward health care cost containment, including ongoing pricing pressures; uncertainties regarding actual or potential legal proceedings, including, among others, actual or potential product liability litigation, litigation and investigations regarding sales and marketing practices, intellectual property disputes, and government investigations generally; and general economic and industry conditions, including uncertainties regarding the effects of the persistently weak economic and financial environment in many countries, uncertainties regarding future global exchange rates, uncertainties in global interest rates, and geopolitical relations, sanctions and tariffs. For further discussion of these and other risks, see HUTCHMED's filings with the US Securities and Exchange Commission, on AIM and on HKEX. HUTCHMED is providing the information in this announcement as of this date and does not undertake any obligation to update any forward-looking statements as a result of new information, future events or otherwise.*

*In addition, this announcement contains statistical data and estimates that HUTCHMED obtained from industry publications and reports generated by third-party market research firms. Although HUTCHMED believes that the publications, reports and surveys are reliable, HUTCHMED has not independently verified the data and cannot guarantee the accuracy or completeness of such data. You are cautioned not to give undue weight to this data. Such data involves risks and uncertainties and are subject to change based on various factors, including those discussed above.*

***Inside Information***

*This announcement contains inside information for the purposes of Article 7 of Regulation (EU) No 596/2014 (as it forms part of retained EU law as defined in the European Union (Withdrawal) Act 2018).*

***Medical Information***

*This announcement contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs including the ones under development.*

**Ends**

**OPERATIONS REVIEW**

**ONCOLOGY/IMMUNOLOGY**

HUTCHMED discovers, develops, manufactures and markets targeted therapies and immunotherapies for the treatment of cancer and immunological diseases through a fully integrated team of approximately 890 scientists and staff, and an in-house oncology commercial organization of approximately 740 staff, based in Shanghai, Suzhou, Beijing and Hong Kong in China and New Jersey in the US.

Out of our 13 drug candidates in various stages of clinical trials, four medicines, fruquintinib, surufatinib, savolitinib and tazemetostat, have been approved in mainland China. Fruquintinib has also been approved in or launched in more than 30 countries, including the US, EU and Japan as of July 2025. Savolitinib has completed an overseas Phase II study and an ongoing Phase III study will potentially support global filings if data proves satisfactory. Our fifth medicine, sovleplenib, has been accepted for review by the NMPA in China, pending approval. Beyond these drug candidates, our novel discovery and early-stage development is focused on progressing drug candidates from our ATTC next-generation technology platform, which currently has several molecules in the pre-clinical stage.

**RESEARCH & DEVELOPMENT**

With US, EU and Japan approvals of fruquintinib in November 2023, June 2024 and September 2024, respectively, we now possess a track record of discovery, clinical development and regulatory submissions of an innovative medicine launched globally. Our strategy is aimed at accelerating our path to establish a long-term sustainable business, by prioritizing late-stage and registrational studies in China and partnering outside of China. HUTCHMED intends to continue to run early phase development programs for selected drug candidates internationally where we believe we can differentiate from a global perspective.

HUTCHMED plans to accelerate innovation through artificial intelligence (AI) integration, with a focus on key R&D stages to improve return on investment (ROI) and iterative learning. In the near term, we plan to expedite the identification of high-potential drug candidates and reduce late-stage pre-clinical attrition. In the medium-term, we target faster patient recruitment through better screening and clinical trial design, leading to R&D efficiency gain with an integrated AI platform.

***Antibody-Targeted Therapy Conjugate Technology Platform***

In January 2025, HUTCHMED announced its next-generation in-house technology platform in antibody-targeted therapy conjugates, or ATTCs. For over three years, we have invested significant resources into this new platform, which should provide multiple drug candidates in the future. Compared to traditional cytotoxin-based antibody-drug conjugates, the traditional toxin-based payload is replaced with a targeted small molecule. Thus, unlike traditional antibody-drug conjugates, ATTCs have potential to be administered in combination with chemotherapy or other targeted agents, which is particularly important in frontline settings.

Another benefit of such design is to further optimize the strength of the small-molecule drug, which may otherwise be limited by a narrow therapeutic window. Through a reduction of off-tumor or off-target toxicity, our platform is designed to deliver highly potent concentrations of small molecule inhibitors to target sites. This has potential to confer efficacy in a broad array of indications with high unmet needs and enable long-term usage. More generally, our ATTC platform has the potential to incorporate high molecular weight drug payloads such as proteolysis targeting chimeras (PROTACs) and protein-protein inhibitors (PPIs).

Pre-clinical data to date suggests robust anti-tumor activity and durable response with our ATTC candidates, compared to monoclonal antibodies in combination with targeted small molecule therapy in a variety of tumor types. IND-enabling work is ongoing and first global clinical trials, including in China, are expected to initiate in late 2025.

Below is a summary update of the clinical trial progress of our investigational drug candidates. For more details about each trial, please refer to recent scientific publications.

**Savolitinib (ORPATHYS**<sup>®</sup> **in China)**

**Mechanism of action**: savolitinib is an oral, potent and highly selective inhibitor of MET. The MET pathway functions abnormally through amplification, overexpression and mutations. The aberrant activation of MET is correlated with tumor growth, survival, invasion, metastasis, suppression of cell death and angiogenesis. MET aberrations may contribute to drug resistance in NSCLC and CRC following anti-EGFR treatment.

**Target indications**: savolitinib was approved for METex14 NSCLC in 2021 in China, where there are 1.06 million new cases of lung cancer (226,000 in the US) in 2022, according to Globocan. About 80-85% are classified as NSCLC, with 2-3% in METex14. In June 2025, savolitinib expanded its indication to EGFRm MET amplified 2L NSCLC in combination with TAGRISSO<sup>®</sup>. In China, 30-40% of NSCLC patients are EGFRm (10-15% in the US). After 1L treatment, about 60% will develop resistance and progress to 2L, of which 1/3 are driven by MET. Separately, MET is an oncogenic driver occurring in 4-6% of GC, leading to poor prognosis. We are developing additional indications for savolitinib in MET overexpressed 1L NSCLC, MET amplified 3L GC and MET-driven PRCC.

**Clinical development**: SACHI China Phase III data was presented at ASCO 2025 late-breaking oral presentation session with **mPFS of 6.9 months (HR 0.32, p<0.0001)** for 2L NSCLC patients who failed prior third-generation EGFR TKI. In a cross-trial comparison against an EGFR-MET bispecific antibody, savolitinib plus TAGRISSO<sup>®</sup> combination shows superior PFS and CNS efficacy. The data also highlights the importance of tissue biopsy and FISH test for differentiated benefits for 2L NSCLC patients, in contrast to a lack of MET-specific data from competing modalities. Our **SAFFRON** global Phase III study is ongoing and **targets to complete patient enrollment in the second half of 2025 and readout data in the first half of 2026.**

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| | | | | |
|:---|:---|:---|:---|:---|
| **Treatment** | **Name: Indication (control); NCT#** | **Endpoint** | **Phase** | **Status/Plan** |
| Savolitinib +<br>TAGRISSO<sup>®</sup> | **SAFFRON:** 2L/3L EGFRm, TAGRISSO<sup>®</sup> refractory, MET amplified or overexpressed **NSCLC** (vs chemo); NCT05261399 | PFS | Global<br>III | Ongoing |
| Savolitinib +<br>TAGRISSO<sup>®</sup> | **SACHI:** 2L EGFRm, EGFR TKI refractory, MET amplified **NSCLC** (vs chemo); NCT05015608 | PFS | China<br>III | NMPA **approved** in Jun 2025. **Data** at ASCO 2025. mPFS 8.2 vs 4.5 months (ITT, HR 0.34), 6.9 vs 3.0 months (post third-generation, HR 0.32) all p<0.0001, mOS 22.9 vs 17.7 months (ITT, HR 0.84, data immature), G≥3 TRAE 45 vs 48% |
| Savolitinib +<br>TAGRISSO<sup>®</sup> | **SAVANNAH:** 2L/3L EGFRm, TAGRISSO<sup>®</sup> refractory, MET amplified or overexpressed **NSCLC** (single-arm); NCT03778229 | ORR | Global<br>II | **Data** at ELCC 2025. By investigator/BICR: ORR 56/55%, mPFS 7.4/7.5 months, mDoR 7.1/9.9 months, G≥3 TEAE 57% |
| Savolitinib +<br>TAGRISSO<sup>®</sup> | **SANOVO:** 1L EGFRm, MET overexpressed **NSCLC** (vs TAGRISSO<sup>®</sup>); NCT05009836 | PFS | China<br>III | Ongoing |
| Savolitinib<br>monotherapy | 1L/2L METex14 **NSCLC** (single-arm); NCT04923945 | ORR | China<br>IIIb | NMPA **approved** in Jan 2025; conditionally approved in 2021. Data at ELCC 2024 and 2025. 1L/2L: ORR 62.1/39.2%, mPFS 13.7/11.0 months, mOS 28.3/25.3 months, G≥3 TEAE 62% |
| Savolitinib<br>monotherapy | 3L **gastric cancer** with MET amplified, two stages (single-arm); NCT04923932 | ORR | China<br>II | Registration twice-daily cohort **LPI** Apr 2025. Data at AACR 2023. 2L+ ORR 50% |
| Savolitinib +<br>IMFINZI<sup>®</sup> | **SAMETA:** MET-driven **PRCC** (vs IMFINZI<sup>®</sup> or SUTENT<sup>®</sup>); NCT05043090 | PFS | Global<br>III | Completed enrollment |

---

For the first time, a China Phase II IIT study (FLOWERS, NCT05163249) of 1L MET amplified/overexpressed EGFRm NSCLC, comparing patients on savolitinib plus TAGRISSO<sup>®</sup> vs. TAGRISSO<sup>®</sup> alone, presented data at WCLC 2024, showing ORR of 90.5% vs. 60.9%, mPFS of 19.6 vs 9.3 months and mDoR of 18.6 vs 8.4 months. Our SANOVO China Phase III study plans to complete enrollment in the second half of 2025.

**Commercial achievement**: savolitinib in combination with TAGRISSO<sup>®</sup> NMPA approval in June 2025 enabled savolitinib to potentially enter NRDL coverage negotiation this year.

---

| | |
|:---|:---|
| **Year** | **Event** |
| 2025 | Approved by the NMPA for MET amplification NSCLC after progression on 1L EGFR inhibitor therapy; Full approval by the NMPA for MET Exon 14 NSCLC (including 1L indication); Approved in Hong Kong under 1+ Mechanism |
| 2023 | NRDL inclusion (renewed in 2024) |
| 2021 | Conditional approval by the NMPA for advanced or metastatic 2L MET Exon 14 NSCLC and launched |
| 2011 | Worldwide license agreement with AstraZeneca |

---

**Fruquintinib (ELUNATE**<sup>®</sup> **in China, FRUZAQLA**<sup>®</sup> **outside of China)**

**Mechanism of action:** fruquintinib is a selective oral inhibitor of VEGFR 1/2/3 kinases, designed to limit off-target kinase activity and improve drug exposure to achieve sustained target inhibition. Inhibition of the VEGFR can stop the growth of the vasculature around tumor and starve the tumor of nutrients and oxygen.

**Target Indications**: fruquintinib was approved and launched for 3L CRC in China in 2018 and approved in the US in 2023. According to Globocan, there were 517,000 new CRC cases in China (160,000 in the US, 540,000 in Europe and 146,000 in Japan) in 2022. About 15-20% of cases progress to 3L. The second approved indication of fruquintinib was in combination with TYVYT<sup>®</sup> for the treatment of 2L EMC with pMMR status. According to Globocan, there were 78,000 new EMC cases in China in 2022. About 15-20% of cases experience recurrence. Third potential indication of fruquintinib in combination with TYVYT<sup>®</sup> for 2L RCC is currently under NMPA review. According to Globocan, there were 74,000 new kidney cancer cases in China in 2022. About 90% are RCC and about 20-30% recur within the first five years.

**Clinical development:** FRUSICA-2 China Phase II/III study in combination with TYVYT<sup>®</sup> for 2L RCC met primary endpoint of PFS in March 2025 and its NMPA filing was accepted in June 2025. We expect data from **FRUSICA-2**, an open-label, active-controlled study of fruquintinib in combination with sintilimab versus axitinib or everolimus monotherapy, **to be presented at ESMO Congress 2025.**

---

| | | | | |
|:---|:---|:---|:---|:---|
| **Treatment** | **Name: Indication (control); NCT#** | **Endpoint** | **Phase** | **Status/Plan** |
| Fruquintinib +<br>TYVYT<sup>®</sup> | **FRUSICA-2:** 2L **RCC** (vs axitinib or everolimus); NCT05522231 | PFS | China<br>II/III | sNDA **accepted by the NMPA** in Jun 2025. Met primary endpoint. |
| Fruquintinib +<br>TYVYT<sup>®</sup> | **RCC** (single-arm); NCT03903705 | ORR | China<br>Ib/II | **Data** in *Targeted Oncology* Jan 2025. 1L/2L: ORR 68.2/60.0%, mPFS not reached/15.9 months, OS 36m 72.4/58.3%, G≥3 TRAE 52.4% |
| Fruquintinib +<br>TYVYT<sup>®</sup> | **FRUSICA-3:** 2L pMMR **EMC** (vs paclitaxel or doxorubicin); NCT06584032 | OS<br>PFS | China<br>III | **FPI** in Dec 2024 |
| Fruquintinib +<br>TYVYT<sup>®</sup> | **FRUSICA-1:** 2L+ pMMR **EMC** (single-arm); NCT03903705 | ORR | China<br>II | NMPA **approved** in Dec 2024. Data at ASCO 2024. ORR 35.6%, mPFS 9.5 months, mOS 21.3 months, G≥3 TRAE 60.2% |
| Fruquintinib +<br>TYVYT<sup>®</sup> | 3L+ **CRC** (single-arm); NCT03903705 | ORR | China<br>Ib/II | **Data** in *European Journal of Cancer* 2023. 5mg 2w/1w regimen pMMR: ORR 20.0%, mPFS 6.9 months, mOS 20.0 months, G≥3 TRAE 47.7% |
| Fruquintinib<br>monotherapy | **FRESCO-2:** 3L+ **CRC** (vs placebo); NCT04322539 | OS | Global<br>III | FDA **approved** in 2023. Data at *The Lancet* 2023. mPFS 3.7/1.8 months (HR 0.32, p<0.001), mOS 7.4/4.8 months (HR 0.66, p<0.001), G≥3 TRAE 62.7% |
| Fruquintinib<br>monotherapy | **FRESCO:** 3L **CRC** (vs placebo); NCT02314819 | OS | China<br>III | NMPA **approved** in 2018. Data at *JAMA* 2018. mPFS 3.7/1.8 months (HR 0.26, p<0.0001), mOS 9.3/6.6 months (HR 0.65, p<0.0001), G≥3 TRAE 61.2% |

---

For 3L CRC, an IIT China Phase II study in combination with TAS-102 (trifluridine/tipiracil hydrochloride) updated data at ASCO 2025 with mPFS of 6.3 months and mOS of 18.4 months, comparable to our previous Phase Ib/II study in combination with TYVYT<sup>®</sup>, with mPFS of 6.9 months and mOS of 20.1 months, similar to or better than new modality in development.

**Commercial achievement**: for China, we launched second indication in 2L EMC, with average treatment duration almost twice that of 3L CRC and will work on NRDL coverage negotiation later this year. For overseas market, our partner Takeda targets over 20% sales growth for its fiscal year of 2025 (March 2026).

---

| | |
|:---|:---|
| **Year** | **Event** |
| 2024 | Conditional approval by NMPA for 2L pMMR EMC |
| 2024 | Approved for 3L+ CRC in the EU, Switzerland, Argentina, Canada, Japan, the UK, Australia, Singapore, Israel, UAE, South Korea; reimbursement in Spain and Japan |
| 2024 | Approved for 3L+ CRC in Hong Kong (first medicine to be approved under the new 1+ Mechanism, first innovative oncology medicine to be directly added for full reimbursement in the Hospital Authority Drug Formulary) |
| 2023 | FDA approval for 3L+ CRC in the US, inclusion in NCCN Clinical Practice Guidelines |
| 2023 | Exclusive worldwide license agreement with Takeda |
| 2020 | NRDL inclusion (renewed in 2022 and 2024) |
| 2018 | Approved for 3L+ CRC by the NMPA and launched |
| 2013 | License and collaboration agreement with Eli Lilly in China (as amended) |

---

**Surufatinib (SULANDA**<sup>®</sup> **in China)**

**Mechanism of action**: surufatinib is a novel, oral angio-immuno kinase inhibitor that selectively inhibits the tyrosine kinase activity associated with VEGFR and FGFR, both involved in tumor angiogenesis, and CSF-1R, which regulates tumor-associated macrophages, promoting immune response against tumor cells. Its dual mechanism of action may be suitable for combinations with other immunotherapies, such as PD-1 antibodies.

**Target indications**: surufatinib was approved in China for non-pancreatic NETs in 2020 and for pancreatic NETs in 2021. There are approximately 40,000 new patients per year in China. Surufatinib is also being investigated in a Phase II/III study for 1L PDAC. PDAC is an aggressive form of cancer, representing over 90% of pancreatic cancer cases. According to Globocan, there were 119,000 new pancreatic cancer cases in China in 2022.

**Clinical development**: last patient was enrolled in November 2024 into the Phase II stage of a Phase II/III randomized, open-label trial to evaluate surufatinib combined with AiRuiKa<sup>®</sup>, nab-paclitaxel, and gemcitabine versus nab-paclitaxel plus gemcitabine as a treatment 1L PDAC. **We target data readout in the second half of 2025.**

---

| | | | | |
|:---|:---|:---|:---|:---|
| **Treatment** | **Name: Indication (control); NCT#** | **Endpoint** | **Phase** | **Status/Plan** |
| Surufatinib +<br>AiRuiKa<sup>®</sup> +<br>chemo | 1L **PDAC**(vs chemo); NCT06361888 | OS | China<br>II/III | Phase II **LPI** Nov 2024 |
| Surufatinib<br>monotherapy | **SANET-ep: epNET**(vs placebo); NCT02588170 | PFS | China<br>III | NMPA **approved** in 2021. ORR 19.2 vs 1.9%, mPFS 10.9 vs 3.7 months (HR=0.49, p=0.001), G≥3 TEAE 69.9 vs 27.1% |
| Surufatinib<br>monotherapy | **SANET-p: pNET**(vs placebo); NCT02589821 | PFS | China<br>III | NMPA **approved** in 2020. ORR 10.3 vs 0.0%, mPFS 9.2 vs 3.8 months (HR=0.33, p<0.0001), G≥3 TEAE 76.7 vs 33.8% |
| Surufatinib<br>monotherapy | 2L+ **pNET/epNET**(single-arm); NCT02549937 | PFS | US/EU<br>Ib | **Data** at ASCO 2021. pNET/epNET: ORR 18.8/6.3%, mPFS 15.2/11.5 months, G≥3 AE 75% |
| Surufatinib<br>monotherapy | **pNET/epNET**(single-arm); NCT02267967 | ORR | China<br>Ib/II | **Data** in *Clinical Cancer Research* 2019. pNET/epNET: ORR 19.0/15.0%, DCR 91.0/92.0%, mPFS 21.2/13.4 months, G≥3 hypertension 33% |

---

**Updated clinical results of a Phase Ib/II IIT** for 1L metastatic PDAC, in combination with AiRuiKa<sup>®</sup>, chemotherapy nab-paclitaxel and S-1, were presented at ASCO 2025 showing ORR of 51.1% (vs 24.4% in chemotherapy control arm) and mPFS of 7.9 months (vs. 5.4 months) (NCT05218889).

**Commercial achievement**: surufatinib achieved market share of 27% in NETs treatment during the third quarter of 2024, ahead of competitors SUTENT<sup>®</sup> and AFINITOR<sup>®</sup>.

---

| | |
|:---|:---|
| **Year** | **Event** |
| 2022 | NRDL inclusion (renewed in 2024) |
| 2021 | Approved for pancreatic NETs by the NMPA and launched |
| 2020 | Approved for non-pancreatic NETs by the NMPA and launched |

---

**Sovleplenib (HMPL-523)**

**Mechanism of action**: sovleplenib is a novel, selective, oral inhibitor targeting Syk. Syk is a kinase upstream to PI3Kδ and BTK within the B-cell signaling pathway and a target for modulating B-cell signaling. We believe it could deliver the same outcome as inhibitors of BTK and PI3Kδ. Its signaling processes do not only affect cells of immune responses but also in tissue pathology in autoimmune, inflammatory and allergic diseases.

**Target indications**: we are developing sovleplenib for ITP and wAIHA. ITP is an autoimmune disorder characterized by immunologic destruction of platelets and decreased platelet production, leading to increased risk of excessive bleeding and bruising. ITP is associated with fatigue (reported in up to 39% of adults with ITP) and impaired quality of life. As platelet destruction in ITP is mediated by Syk-dependent phagocytosis of FcγR-bound platelets, Syk inhibition is a promising approach to ITP management. According to IQVIA, China has 47,000 new ITP patients every year, on top of another 421,000 existing patients. About half of ITP patients cannot get satisfactory results from currently approved treatments such as TPO/TPO-RAs. NMPA has accepted our NDA filing for 2L ITP and we target **re-submission in first half of 2026, with additional data rolling in during second half of 2026. In the future, the Company will look to continue overseas development.**

AIHA is another autoimmune disorder where the immune system mistakenly attacks and destroys own red blood cells, leading to anemia. It has no approved treatment, with annual incidence of 0.8-3.0/100,000 and prevalence of 9.5-17/100,000. wAIHA accounts for 75-80% of AIHA cases. China has 16,000 new wAIHA patients per year. We are in ESLIM-02 China Phase III study for 2L wAIHA and completed enrollment in June 2025, targeting data readout in 2026.

**Clinical development**: ESLIM-01 study showed that, apart from its durable response in ITP patients, sovleplenib also significantly improved quality of life in physical functioning and energy/fatigue (*p*<0.05). Most patients were heavily pretreated with a median of four prior lines of ІTP therapy, and a majority (71.3%) of the patients had received prior TPO/TPO-RA treatment. Further post-hoc subgroup analysis of the study demonstrated consistent clinical benefits across ІTP patients regardless of prior lines of ІTP therapies or prior TPO/TPO-RA exposure.

Long-term follow-up results of the same study were presented at ASH 2024. A total of 179 pts (All Sov) were treated with at least one dose of sovleplenib, including 126 patients who initially received sovleplenib and 53 patients who crossed over from placebo (P-Sov). The durable response rate was 51.4% and 43.4% for the two groups and **long-term durable response rate was 59.8% and 64.2%,** with median cumulative duration of response of 38.9 weeks and 35.1 weeks, respectively. In the All Sov group, 54% of patients achieved duration of response of 48 weeks or more and 26% lasted for 72 weeks or more.

---

| | | | | |
|:---|:---|:---|:---|:---|
| **Treatment** | **Name: Indication (control); NCT#** | **Endpoint** | **Phase** | **Status/Plan** |
| Sovleplenib | **ESLIM-01**: ≥2L **ITP**(vs placebo); NCT05029635 | DRR | China<br>III | NDA **accepted by the NMPA** in Jan 2024. Data at ASH 2024. After placebo cross-over: ORR 81.0%, DRR 51.4%, G≥3 TRAE 8.9% |
| Sovleplenib | ≥2L **ITP**(vs placebo); NCT03951623 | Safety | China<br>Ib/II | **Data** in *The Lancet Haematology* 2023. Including placebo cross-over: ORR 80%, DRR 40%, G≥3 TRAE 7% |
| Sovleplenib | **ESLIM-02:** 2L **warm AIHA**(vs placebo); NCT05535933 | DRR | China<br>II/III | Phase III **LPI** Jun 2025 |
| Sovleplenib | 2L **warm AIHA**(vs placebo); NCT05535933 | DRR | China<br>II/III | Phase II **data** in *The Lancet Haematology* 2025. Including placebo cross-over: ORR 67%, DRR 48%, G≥3 TEAE 33% |

---

There has been extensive research on oral small-molecule Syk inhibitors due to the major unmet medical needs in inflammation and oncology. However, many Syk inhibitors have failed in the development stage due to their off-target toxicity as a result of lower kinase selectivity and possibly poor pharmacokinetic properties. There is only one FDA-approved Syk inhibitor for ITP. There are competitors of different modalities targeting ITP, including BTK inhibitor and FcRn inhibitor. However, their 24-week durable response rates were either not disclosed or significantly below that of sovleplenib.

**Tazemetostat (TAZVERIK**<sup>®</sup> **in China)**

We have a collaboration with Epizyme, a subsidiary of Ipsen, to research, develop, manufacture and commercialize tazemetostat in Greater China, including the mainland, Hong Kong, Macau and Taiwan.

**Mechanism of action**: tazemetostat is an inhibitor of EZH2. EZH2 catalyzes the methylation of histone H3 at lysine 27, which controls expression of genes and plays a role in cell physiology. Dysregulation of EZH2 occurs in a wide range of cancers with poor prognosis. Tazemetostat inhibits EZH2 which allows transcription of genes involved in cell cycle control and terminal differentiation, thus inhibiting cancer cell proliferation.

**Target indications**: tazemetostat was approved in China for 3L R/R EZH2-mutant follicular lymphoma in March 2025. China has about 9,000 new follicular lymphoma patients each year. About 1/3 of them will eventually require 3L treatment and the frequency of EZH2 mutation was about 25%. We are collaborating with Epizyme to expand the indication to 3L follicular lymphoma regardless of EZH2 status. Tazemetostat received FDA approval in 2020 for epithelioid sarcoma and R/R 2L+ EZH2-mutant follicular lymphoma or R/R follicular lymphoma with no satisfactory alternatives. It is marketed by Ipsen in the US and by Eisai in Japan. In May 2022, tazemetostat was approved in the Hainan International Medical Tourism Pilot Zone, under the Clinically Urgently Needed Imported Drugs scheme.

**Clinical development**: NMPA conditional approval in March 2025 was supported by a China Phase II bridging study, showing ORR of 63.6% and mPFS of 15.4 months, in line with results of an earlier global trial (ORR 69%, mPFS 13.8 months). **This bridging study also has another cohort for EZH2 wild-type patients with data to be released.**

---

| | | | | |
|:---|:---|:---|:---|:---|
| **Treatment** | **Name: Indication (control); NCT#** | **Endpoint** | **Phase** | **Status/Plan** |
| Tazemetostat<br>monotherapy | R/R 3L+ **follicular lymphoma**(EZH2m/wildtype 2 cohorts); NCT05467943 | ORR | China<br>II  | NMPA **approved** in Mar 2025. Data at EHA 2025.<br>EZH2m by IRC: ORR 63.6%, mPFS 15.4 months, DoR 18m 51.6%, G≥3 TRAE 13.6% |
| Tazemetostat+<br>lenalidomide +<br>rituximab (R²) | **SYMPHONY-1:** 2L+ **follicularlymphoma** (vs R² + placebo);<br>NCT04224493 | PFS  | Global<br>Ib/III | Ongoing since 2020. Phase Ib **Data** at ASH 2023. ORR 90.9%, 18-month PFS 79.5%, 18-month DoR 81.0%, G≥3 neutropenia 40.9%, RP3D determined |
| Tazemetostat+<br>amdizalisib | 2L+ R/R **PTCL**(single-arm); NCT05713110 | ORR | China<br>II | **Data** at ICML 2025. ORR 60.7%, mPFS 8.3 months, mDoR 6.5 months, G≥3 TRAE 48.3% |

---

**Commercial achievements**: NMPA approval in March 2025 triggered an outgoing milestone payment to Epizyme. During the first week of July 2025, the first prescription for tazemetostat, our first commercialized hematological oncology drug, was filled with the drug delivered to the patient. We have established a dedicated team to market tazemetostat and other hematological drugs under development, such as sovleplenib and ranosidenib, to be potentially commercialized by our team in coming years.

---

| | |
|:---|:---|
| **Year** | **Event** |
| 2025 | Conditional approval by the NMPA for R/R follicular lymphoma and launched |
| 2022 | Approved for R/R follicular lymphoma and launched in Hainan Pilot Zone |
| 2021 | License and collaboration agreement with Epizyme, now a subsidiary of Ipsen |
| 2020 | Approved by FDA for epithelioid sarcoma and R/R follicular lymphoma |

---

**Fanregratinib (HMPL-453)**

**Mechanism of action**: fanregratinib is a novel, selective, oral inhibitor targeting FGFR 1/2/3. Activation of the FGFR pathway ultimately leads to increased cell proliferation, migration and survival. Aberrant FGFR signaling is associated with tumor growth, promotion of angiogenesis and resistance to anti-tumor therapies. Deregulation of the FGFR includes receptor amplification, activating mutations, gene fusions, and receptor isoform switching.

**Target indications**: IHCC is one of the subtypes of primary bile duct cancer. In China, an estimated 61,900 newly diagnosed IHCC occurred in 2015 and the overall IHCC incidence increased by 9.2% per year between 2006 and 2015. Approximately 10-15% of IHCC patients globally have tumors harboring FGFR2 fusions or rearrangements.

**Clinical development**: fanregratinib has been studied in clinical trials with around 310 patients to date. We completed recruitment of the registrational cohort of a China Phase II trial in February 2025 and **expect readout later in the first half of 2026.**

---

| | | | |
|:---|:---|:---|:---|
| **Treatment** | **Name: Indication (control); NCT#** | **Endpoint** | **Status/Plan** |
| Fanregratinib<br>monotherapy | 2L FGFR2 fusion/rearrangement **IHCC**(single-arm); NCT04353375 | ORR<br> China<br>II  | **LPI** Feb 2025. Readout expected in the first half of 2026 |
| Fanregratinib<br>monotherapy | 2L+ FGFR2 fusion/rearrangement **IHCC**(2-dosage cohorts); NCT04353375 | ORR<br> China<br>II | **Data** at ASCO 2023. At 300mg, ORR 50.0%, DCR 90%, G≥3 TRAE 23.1% |

---

**Ranosidenib (HMPL-306)**

**Mechanism of action**: ranosidenib is a novel dual-inhibitor of IDH1 and IDH2 enzymes. When mutated, IDH creates 2-hydroxyglutarate, which alters genetic programming and prevents cells from maturing, causing activation of oncogenes and deactivation of tumor-suppressor genes. Targeting both IDH1 and IDH2 mutations benefits patients harboring either IDH mutation and addresses acquired resistance due to isoform switching.

**Target indications**: IDH1 and IDH2 mutations have been implicated as drivers of certain malignancies, especially AML, and gliomas. There were an estimated 19,700 new cases of AML in China in 2018 and is estimated to reach 24,200 in China in 2030. About 15-25% of AML carry IDH1/2 mutations. Nearly 25% of AML patients fail to achieve remission after treatment.

**Clinical development**: RAPHAEL China Phase III study initiated in May 2024 on 2L R/R IDH1/2-mutant AML patients, comparing ranosidenib monotherapy versus chemotherapy. With OS as primary endpoint, we target recruitment of 320 patients and **estimate NDA filing in 2027.**

---

| | | | | |
|:---|:---|:---|:---|:---|
| **Treatment** | **Name: Indication (control); NCT#** | **Endpoint** | **Phase** | **Status/Plan** |
| Ranosidenib<br>monotherapy | **RAPHAEL:** 2L R/R IDH1/2-mutant AML (vs chemo); NCT06387069 | OS | China<br>III | Ongoing since May 2024 |
| Ranosidenib<br>monotherapy | IDH1/2-mutant **AML**(single-arm); NCT04272957 | Safety | China<br>I | **Data** at EHA 2024. At RP2D, IDH1/2-mutant CR+CRh 45.5/50.0%; Excluding RAS and FLT3 mutations, IDH1/2-mutant CR+CRh 50.0/62.0% |
| Ranosidenib<br>monotherapy | R/R IDH1/2-mutant **AML**(single-arm); NCT04764474 | Safety | US/EU<br>I | **Data** at EHA 2024. At 250mg, ORR 60.0%, G≥3 TRAE 13.3% |
| Ranosidenib<br>monotherapy | IDH1/2-mutant **glioma**(single-arm); NCT07025018 | Safety | China<br>I | **FPI** July 2025 |
| Ranosidenib<br>monotherapy | IDH1/2-mutant **glioma**(single-arm); NCT04762602 | Safety | US/Spain<br>I | **Data** at ASCO 2025. For lower-grade glioma patients, ORR 20.0%, 18-month PFS rate 65.3%, G≥3 AE 28.6% |

---

There is one IDH1/2 dual inhibitor approved in the US for IDH1/2-mutant Grade 2 astrocytoma or oligodendroglioma in August 2024. So far, there are no IDH1/2 dual inhibitors approved or in late-stage development for AML.

**Early-stage Investigational Drug Candidates**

HUTCHMED retains all worldwide rights to the following early-stage drug candidates.

---

| | | | |
|:---|:---|:---|:---|
| **Treatment** | **Name: Indication (control); NCT#** | **Endpoint** | **Status/Plan** |
| HMPL-760 +<br>chemo | R/R **DLBCL**(vs chemo); NCT06601504 | Safety<br>PFS<br> China<br>II | Ongoing since Nov 2024 |
| HMPL-760<br>monotherapy | **CLL, SLL, other B-NHL**(single-arm); NCT05190068 | ORR<br> China<br>I | **Data** at EHA 2024. ORR 73.1%, median time to response 2.3 months |
| HMPL-506<br>monotherapy | MLL-rearranged/NPM1-mutant **acute leukemia** (single-arm); NCT06387082 | RP2D<br> China<br>I | Ongoing since Jun 2024 |
| HMPL-415<br>monotherapy | **Solid tumors**(single-arm); NCT05886374 | RP2D<br> China<br>I | Ongoing since Jul 2023 |
| HMPL-653<br>monotherapy | **Solid tumors & tenosynovial giant cell tumors** (single-arm); NCT05277454 | RP2D<br> China<br>I | Ongoing since 2022; fully enrolled |
| HMPL-A83<br>monotherapy | Advanced **malignant neoplasms**(single-arm); NCT05429008 | RP2D<br> China<br>I | Ongoing since 2022 |
| HMPL-295<br>monotherapy | **Solid tumors**(single-arm); NCT04908046 | G≥3 <br>TRAE<br> China<br>I | **Data** at ASCO 2024. G≥3 TRAE 53.2% |

---

**HMPL-760 is a novel, non-covalent, third-generation BTK inhibitor.** It is a highly potent, selective, and reversible inhibitor with long target engagement against BTK, including wild-type and C481S-mutated BTK. The abnormal activation of B-cell receptor signaling is closely related to the development of B-cell type hematological cancers, which represent approximately 85% of all NHL cases. BTK is considered a validated target for drugs that aim to treat certain hematological cancers, however C481S mutation of BTK is a known resistance mechanism for first and second generation BTK inhibitors.

**HMPL-506 is a novel, selective Menin inhibitor.** Menin is a scaffold protein that controls gene expression and cell signaling. MLL rearrangement and NPM1 mutation play key roles in acute leukemia. Current research has demonstrated that the inhibition of Menin-MLL interaction is a feasible therapeutic strategy in these MLL or NPM1 types of acute leukemia. MLL-rearranged AML accounts for approximately 5% of adult AML, associated with poor prognosis, and NPM1-mutant AML accounts for approximately 30% of AML.

**HMPL-415 is a novel SHP2 allosteric inhibitor.** SHP2 modulates diverse cell signaling events that control metabolism, cell growth, differentiation, cell migration, transcription and oncogenic transformation. It regulates key signaling events including RAS/ERK, PI3K/AKT, JAK/STAT and PD-1 pathways downstream of several receptor tyrosine kinases. Dysregulation of SHP2 expression or activity causes many developmental diseases, and hematological and solid tumors.

**HMPL-653 is a novel, selective and potent CSF-1R inhibitor** designed to target CSF-1R driven tumors as a monotherapy or in combination with other drugs. Studies have shown that blocking the CSF-1R signaling pathway could effectively modulate the tumor microenvironment, relieve tumor immunosuppression, and synergize with other anti-cancer therapies such as immune checkpoint inhibitors to achieve tumor inhibition. CSF-1R inhibitors may treat tenosynovial giant cell tumors and a variety of malignancies in combinations.

**HMPL-A83 is a novel IgG4-type humanized anti-CD47 monoclonal antibody** that exhibits high affinity for CD47**.** CD47 is a cell surface transmembrane protein that is ubiquitously expressed on virtually all human cells. The overexpression of CD47 is reported in a variety of tumors and is believed to be associated with immune escape from macrophage-mediated phagocytosis. HMPL-A83 blocks CD47 binding to signal regulatory protein α and disrupts the "do not eat me" signal that cancer cells use to shield themselves from the immune system.

**HMPL-295 is a novel ERK inhibitor.** ERK is a downstream component of the RAS-RAF-MEK-ERK signaling cascade (MAPK pathway). The MAPK pathway is dysregulated in cancer, in which mutations or non-genetic events hyper-activate the pathway in up to 50% of cancers. ERK inhibition has the potential to overcome or avoid the intrinsic or acquired resistance from the inhibition of RAS, RAF and MEK. HMPL-295 inhibited ribosomal S6 kinase (RSK) phosphorylation which is a downstream signaling molecule regulated by ERK1/2 and stimulated by phorbol 12-myristate 13-acetate (PMA).

**Collaborations with ImageneBio, Inc. (Nasdaq:IMA) and Miragene Inc.**

Inmagene has been developing two novel drug candidates (IMG-004 and IMG-007) discovered by HUTCHMED for the potential treatment of multiple immunological diseases and funded by Inmagene. HUTCHMED received shares representing approximately 7.5% of the shares in Inmagene (fully diluted) in July 2024, as consideration for Inmagene's exclusive license to further develop, manufacture and commercialize these two drug candidates worldwide.

On July 25, 2025, Inmagene merged with Ikena Oncology, Inc forming **ImageneBio, Inc.,** which holds the IMG-007 license rights. As a result of the merger, HUTCHMED has an approximate 3.67% shareholding in ImageneBio. Immediately prior to the merger, the license rights granted by HUTCHMED to the IMG-004 candidate were spun-off to a company called Miragene Inc. in which HUTCHMED has an approximate 9.39% shareholding. HUTCHMED's shareholding in Inmagene was cancelled at the same time as these transactions completed.

---

| | | | | |
|:---|:---|:---|:---|:---|
| **Treatment** | **Name: Indication (control); NCT#** | **Endpoint** | **Phase** | **Status/Plan** |
| IMG-007<br>monotherapy | Adults with moderate-to-severe<br>**atopic dermatitis**(cohort 1: single-arm; cohort 2: vs placebo); NCT05984784 | Safety | US/<br>Canada<br>IIa | Positive topline. Mean reduction in EASI 71% (4-week), EASI-75 response 54% (16-week),<br>IIb planned Q1 2025 |
| IMG-007<br>monotherapy | **Alopecia areata** with 50% or greater<br>scalp hair loss<br>(single-arm); NCT06060977 | Safety | US/<br>Canada<br>IIa | Fully enrolled; results pending |
| IMG-007<br>monotherapy | Adult healthy volunteers<br>(vs placebo); NCT05349097 | Safety | US<br>I | Multiple ascending dose completed |

---

**MANUFACTURING**

We have a drug product manufacturing facility in Suzhou which manufactures both clinical and commercial supplies for fruquintinib and surufatinib. Our new drug product facility in Shanghai is expected to increase our novel drug product manufacturing capacity by over five times. All our clinical supplies have completed technology transfer and are now being produced by our Shanghai factory. Our commercial supplies have also gradually migrated to this new facility, with significant production cost savings.

Commercial supply of savolitinib has already been delivered from the Shanghai facility in late 2024. We have received the manufacturing approval of surufatinib at the Shanghai facility and started commercial production. We have also submitted the application for the manufacturing approval of the third product, fruquintinib. We continue to deliver commercial batches of FRUZAQLA<sup>®</sup> from two manufacturing sites to the global markets: our own facility in Suzhou and a second site in Switzerland.

For our first ATTC candidates, the Shanghai facility has completed production. We have also completed the first batch of drug product for the first global clinical supply.

**OTHER VENTURES**

In the first half of 2025, HUTCHMED completed the disposal of a 45% equity interest in SHPL to focus on our global innovative drug discovery and development businesses. After the disposal, our Other Ventures is predominantly our Distribution Business (a 51%-held joint venture with Sinopharm Group Co. Ltd.) which provides services to third-party pharmaceutical companies in China.

In the first half of 2025, our Other Ventures consolidated revenue were steady at $134.2 million (H1-24: $137.0m). Consolidated net income attributable to HUTCHMED from our Other Ventures increased to $440.3 million (H1-24: $34.1m) primarily due to disposal of 45% equity interest in SHPL in April 2025, contributing a one-time $416.3 million divestment gain net of tax.

**Weiguo Su**

**Chief Executive Officer and Chief Scientific Officer**

**August 7, 2025**

**USE OF NON-GAAP FINANCIAL MEASURES AND RECONCILIATION**

In addition to financial information prepared in accordance with US GAAP, this announcement also contains certain non-GAAP financial measures based on management's view of performance including:

&nbsp;&nbsp;&nbsp;&nbsp;● Adjusted Group net cash flows excluding financing activities

&nbsp;&nbsp;&nbsp;&nbsp;● CER

Management uses such measures internally for planning and forecasting purposes and to measure the HUTCHMED Group's overall performance. We believe these adjusted financial measures provide useful and meaningful information to us and investors because they enhance investors' understanding of the continuing operating performance of our business and facilitate the comparison of performance between past and future periods. These adjusted financial measures are non-GAAP measures and should be considered in addition to, but not as a substitute for, the information prepared in accordance with US GAAP. Other companies may define these measures in different ways.

*Adjusted Group net cash flows excluding financing activities:* We exclude deposits in and proceeds from short-term investments for the period and exclude the net cash generated from financing activities for the period to derive our adjusted Group net cash flows excluding financing activities. We believe the presentation of adjusted Group net cash flows excluding financing activities provides useful and meaningful information about the change in our cash resources excluding those from financing activities which may present significant period-to-period differences.

*CER:* We remove the effects of currency movements from period-to-period comparisons by retranslating the current period's performance at previous period's foreign currency exchange rates. Because we have significant operations in China, the RMB to US dollar exchange rates used for translation may have a significant effect on our reported results. We believe the presentation at CER provides useful and meaningful information because it facilitates period-to-period comparisons of our results and increases the transparency of our underlying performance.

**Reconciliation of GAAP change in net cash used in operating activities to adjusted Group net cash flows excluding financing activities:**

---

| | | |
|:---|:---|:---|
|  | **Six months ended June 30,** | **Six months ended June 30,** |
| ($ in millions) | **2025** | **2024** |
| Net cash used in operating activities | (72.9) | (39.8) |
| Net cash generated from/(used in) investing activities | 17.6 | (5.4) |
| Effect of exchange rate changes on cash and cash equivalents | 2.7 | (1.8) |
| &nbsp;&nbsp;Excludes: Deposits in short-term investments | 1301.8 | 991.0 |
| &nbsp;&nbsp;Excludes: Proceeds from short-term investments | (730.1) | (995.3) |
| Adjusted Group net cash flows excluding financing activities | 519.1 | (51.3) |

---

**Reconciliation of GAAP revenue and net income attributable to HUTCHMED to CER:**

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
|  | **Six Months Ended** | **Six Months Ended** | **Change Amount** | **Change Amount** | **Change Amount** | **Change %** | **Change %** | **Change %** |
|  | **June 30,**  | **June 30,**  |  |  | **Exchange**  |  |  | **Exchange**  |
| ($ in millions, except %) | **2025** | **2024** | **Actual** | **CER** | **effect** | **Actual**  | **CER**  | **effect** |
| **Consolidated revenue** | **277.7** | **305.7** | **(28.0)** | **(26.6)** | **(1.4)** | **-9%** | **-9%** | **—** |
| — **Oncology/Immunology\*** | **143.5** | **168.7** | **(25.2)** | **(25.0)** | **(0.2)** | **-15%** | **-15%** | **—** |
| \* Includes: |  |  |  |  |  |  |  |  |
| &nbsp;&nbsp;— Oncology Products | 99.1 | 127.8 | (28.7) | (28.5) | (0.2) | -22% | -22% |  |
| &nbsp;&nbsp;&nbsp;&nbsp;— FRUZAQLA<sup>®</sup> | 43.1 | 42.8 | 0.3 | 0.3 |  | 1% | 1% |  |
| &nbsp;&nbsp;&nbsp;&nbsp;— ELUNATE<sup>®</sup> | 33.6 | 46.0 | (12.4) | (12.2) | (0.2) | -27% | -27% |  |
| &nbsp;&nbsp;&nbsp;&nbsp;— SULANDA<sup>®</sup> | 12.7 | 25.4 | (12.7) | (12.7) |  | -50% | -50% |  |
| &nbsp;&nbsp;&nbsp;&nbsp;— ORPATHYS<sup>®</sup> | 9.0 | 13.1 | (4.1) | (4.1) |  | -32% | -32% |  |
| &nbsp;&nbsp;&nbsp;&nbsp;— TAZVERIK<sup>®</sup> | 0.7 | 0.5 | 0.2 | 0.2 |  | 49% | 49% |  |
| &nbsp;&nbsp;— Takeda upfront, regulatory milestones and R&D services | 29.5 | 33.8 | (4.3) | (4.3) |  | -13% | -13% |  |
| &nbsp;&nbsp;— Other revenue (R&D services and licensing) | 14.9 | 7.1 | 7.8 | 7.8 |  | 111% | 111% |  |
| — **Other Ventures** | **134.2** | **137.0** | **(2.8)** | **(1.6)** | **(1.2)** | **-2%** | **-1%** | **-1%** |
| **Consolidated net income attributable to HUTCHMED** — **Other Ventures** | **440.3** | **34.1** | **406.2** | **406.4** | **(0.2)** | **1,189%** | **1,190%** | **-1%** |
| &nbsp;&nbsp;— Gain on divestment of an equity investee  | 416.3 |  | 416.3 | 416.3 |  | n/a | n/a | n/a |
| &nbsp;&nbsp;— Consolidated entities | 0.9 | 0.3 | 0.6 | 0.5 | 0.1 | 150% | 139% | 11% |
| &nbsp;&nbsp;— An equity investee — SHPL | 23.1 | 33.8 | (10.7) | (10.4) | (0.3) | -32% | -31% | -1% |

---

**GROUP CAPITAL RESOURCES**

**LIQUIDITY AND CAPITAL RESOURCES**

To date, we have taken a multi-source approach to fund our operations, including through cash flows generated and dividend payments from our Oncology/Immunology and Other Ventures operations, service and milestone and upfront payments from our collaboration partners, bank borrowings, investments from third parties, proceeds from our listings on various stock exchanges and follow-on offerings.

Significantly boosted by the partial disposal of equity stake in SHPL, we generated a net income attributable to HUTCHMED of $455.0 million for the six months ended June 30, 2025 (H1-24: $25.8m).

As of June 30, 2025, we had cash and cash equivalents and short-term investments of $1,364.5 million, unutilized bank facilities of $54.0 million and $93.4 million in bank borrowings.

Certain of our subsidiaries, including those registered as wholly foreign-owned enterprises in China, are required to set aside at least 10.0% of their after-tax profits to their general reserves until such reserves reach 50.0% of their registered capital.

Profit appropriated to the reserve funds for our equity investee incorporated in the PRC was approximately $2.1 million and nil for the six months ended June 30, 2025 and 2024, respectively. In addition, as a result of PRC regulations restricting dividend distributions from such reserve funds and from a company's registered capital, our PRC subsidiaries are restricted in their ability to transfer a certain amount of their net assets to us as cash dividends, loans or advances. This restricted portion amounted to $2.0 million as of June 30, 2025.

**CASH FLOW**

---

| | | |
|:---|:---|:---|
|  | **Six months ended June 30,** | **Six months ended June 30,** |
| (in $'000) | **2025** | **2024** |
| **Cash Flow Data:** |  |  |
| Net cash used in operating activities | (72894) | (39832) |
| Net cash generated from/(used in) investing activities | 17593 | (5435) |
| Net cash generated from/(used in) financing activities | 9321 | (32562) |
| Net decrease in cash and cash equivalents | (45980) | (77829) |
| Effect of exchange rate changes | 2741 | (1807) |
| Cash and cash equivalents at beginning of the period | 153958 | 283589 |
| Cash and cash equivalents at end of the period | 110719 | 203953 |

---

**Net Cash used in Operating Activities**

Net cash used in operating activities was $72.9 million for the six months ended June 30, 2025, compared to $39.8 million for the six months ended June 30, 2024. The net increase in spending of $33.1 million was mainly due to $59.5 million capital gain tax payment for the partial divestment of SHPL in April 2025, offset by $23.3 million lower research and development expenses ($72.0 million as compared to $95.3 million for the six months ended June 30, 2025 and 2024 respectively).

**Net Cash generated from/(used in) Investing Activities**

Net cash generated from investing activities was $17.6 million for the six months ended June 30, 2025, compared to $5.4 million net cash used for the six months ended June 30, 2024. The net amounts generated for the six months ended June 30, 2025 were due to gross proceeds from the partial divestment of SHPL of $608.5 million, offset by $571.7 million deposited into short-term investments along with $10.0 million regulatory approval milestone payment and $9.2 million for capital expenditures. The net amounts used for the six months ended June 30, 2024 were mainly due to capital expenditures of $10.1 million, offset by net withdrawals from short-term investments of $4.3 million.

**Net Cash generated from/(used in) Financing Activities**

Net cash generated from financing activities was $9.3 million for the six months ended June 30, 2025, compared to net cash used in financing activities of $32.6 million for the six months ended June 30, 2024. The net amounts generated for the six months ended June 30, 2025 were mainly due to $8.2 million drawn from bank borrowings to settle the capital expenditures for the Shanghai manufacturing site. The net amounts used for the six months ended June 30, 2024 were mainly due to $36.1 million purchases of shares of the Company by a trustee (which are referred to as "treasury shares" in the Company's financial statements and accounted as treasury shares under applicable accounting standards but do not constitute treasury shares under the Rules Governing the Listing of Securities on HKEX (the "Hong Kong Listing Rules")) for the settlement of equity awards of the Company.

**LOAN FACILITIES**

In October 2021, our subsidiary entered into a 10-year fixed asset loan facility agreement with BOC for the provision of a secured credit facility in the amount of $105.5 million (RMB754.9 million) with an annual interest rate at the 5-year China LPR less 0.8% (which was supplemented in June 2022). This credit facility is guaranteed by another subsidiary of the Group, and secured by the underlying leasehold land and buildings (Shanghai manufacturing facility), and includes certain financial covenant requirements. As of June 30, 2025, $70.6 million (RMB505.6 million) was utilized from the fixed asset loan facility.

In October 2024, our subsidiary entered into a short-term unsecured working capital loan facility with BOC in the amount of $41.9 million (RMB300.0 million) with an annual interest rate at the 1-year China LPR less 0.82%. This credit facility includes certain financial covenant requirements. As of June 30, 2025, $22.8 million (RMB163.1 million) was utilized from the loan facility.

**CONTRACTUAL OBLIGATIONS AND COMMITMENTS**

The following table sets forth our contractual obligations as of June 30, 2025. Our purchase obligations relate to property, plant and equipment that are contracted for but not yet paid. Our lease obligations primarily comprise future aggregate minimum lease payments in respect of various factories, warehouse, offices and other assets under non-cancellable lease agreements.

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
|  | **Payment Due by Period** | **Payment Due by Period** | **Payment Due by Period** | **Payment Due by Period** | **Payment Due by Period** |
|  |  | **Less than** |  |  | **More than** |
| (in $'000) | **Total** | **1 Year** | **1-3 Years** | **3-5 Years** | **5 Years** |
| Bank borrowings | 93444 | 25603 | 8423 | 28076 | 31342 |
| Interest on bank borrowings | 9588 | 2392 | 3505 | 2640 | 1051 |
| Purchase obligations | 1430 | 1430 |  |  |  |
| Lease obligations | 7286 | 4097 | 2989 | 200 |  |
|  | 111748 | 33522 | 14917 | 30916 | 32393 |

---

**FOREIGN EXCHANGE RISK**

A substantial portion of our revenue and expenses are denominated in renminbi, and our consolidated financial statements are presented in US dollars. While we do not believe that we currently have any significant direct foreign exchange risk and have not used any derivative financial instruments to hedge our exposure to such risk, any significant fluctuation in the value of renminbi may adversely affect our cash flows, results of operations and financial condition in the future.

The value of the renminbi against the US dollar and other currencies may fluctuate and is affected by, among other things, changes in political, economic and market factors, including but not limited to monetary policies, interest rates, geopolitical relations, tariffs and economic performance. The conversion of renminbi into foreign currencies, including US dollars, has been based on rates set by the PBOC. If we decide to convert renminbi into US dollars for the purpose of making payments for dividends on our ordinary shares or ADSs or for other business purposes, appreciation of the US dollar against the renminbi would have a negative effect on the US dollar amounts available to us. On the other hand, if we need to convert US dollars into renminbi for business purposes, e.g. capital expenditures and working capital, appreciation of the renminbi against the US dollar would have a negative effect on the renminbi amounts we would receive from the conversion. In addition, for certain cash and bank balances deposited with banks in the PRC, if we decide to convert them into foreign currencies, they are subject to the rules and regulations of foreign exchange control promulgated by the PRC government.

**CREDIT RISK**

Substantially all of our bank deposits are in major financial institutions, which we believe are of high credit quality. We limit the amount of credit exposure to any single financial institution. We make periodic assessments of the recoverability of trade and other receivables and amounts due from related parties. Our historical experience in collection of receivables falls within the recorded allowances, and we believe that we have made adequate provision for uncollectible receivables.

**INTEREST RATE RISK**

We have no significant interest-bearing assets except for bank deposits. Our exposure to changes in interest rates is mainly attributable to our bank borrowings, which bear interest at floating interest rates and expose us to cash flow interest rate risk. We have not used any interest rate swaps to hedge our exposure to interest rate risk. We have performed sensitivity analysis for the effects on our results for the period from changes in interest rates on floating rate borrowings. The sensitivity to interest rates used is based on the market forecasts available at the end of the reporting period and under the economic environments in which we operate, with other variables held constant. According to the analysis, the impact on our results of a 1.0% interest rate shift would be a maximum increase/decrease of $0.4 million for the six months ended June 30, 2025.

**OFF-BALANCE SHEET ARRANGEMENTS**

We did not have during the years presented, and we do not currently have, any material off-balance sheet arrangements.

**CONTINGENT LIABILITIES**

Other than as disclosed in note 12 to the interim financial statements, the Group does not have any other significant commitments or contingent liabilities.

**GEARING RATIO**

The gearing ratio of the Group, which was calculated by dividing total interest-bearing loans by total equity, was 7.5% as of June 30, 2025, a decrease from 10.7% as of December 31, 2024. The decrease was primarily due to the increase in equity from the gain on divestment of SHPL during the period.

**SIGNIFICANT INVESTMENTS HELD**

Except for our investment in a non-consolidated equity investee SHPL with a carrying value of $3.6 million including details below and those as disclosed in note 7 to the interim financial statements, we did not hold any other significant investments in the equity of any other companies as of June 30, 2025.

---

| | | | |
|:---|:---|:---|:---|
| Place of establishment | Nominal Value of  | Equity Interest  |  |
| and operations  | Registered Capital | Attributable to the Group | Principal activities |
|  | (in RMB'000) |  |  |
| PRC | 229000 | 5% | Manufacture and distribution of prescription drug products |

---

Our own-brand prescription drugs business under our Other Ventures is operated through SHPL. Dividends received from SHPL for the six months ended June 30, 2025 were $7.0 million.

**FUTURE PLANS FOR MATERIAL INVESTMENTS AND CAPITAL ASSETS**

Note 12 to the interim financial statements discloses our capital commitment as of June 30, 2025. Subsequent to the construction completion of the drug product facility in Shanghai, certain investments in capital assets in relation to the facility will be made.

**MATERIAL ACQUISITIONS AND DISPOSALS OF SUBSIDIARIES, ASSOCIATES AND JOINT VENTURES**

Note 16 to the interim financial statements discloses our divestment of an equity investee during the six months ended June 30, 2025. Except for the above transactions, we did not have any other material acquisitions and disposals of subsidiaries, associates and joint ventures.

**PLEDGE OF ASSETS**

Our 10-year fixed asset loan facility agreement with BOC is secured by the underlying leasehold land and buildings. $70.6 million (RMB 505.6 million) was utilized from the fixed asset loan facility as of June 30, 2025.

**INFLATION**

In recent years, China has not experienced significant inflation, and thus inflation has not had a material impact on our results of operations. According to the National Bureau of Statistics of China, the Consumer Price Index in China decreased by 0.3% in 2023, increased by 0.1% in 2024 and increased by 0.1% in the first half of 2025. Although we have not been materially affected by inflation in the past, we can provide no assurance that we will not be affected in the future by higher rates of inflation in China.

**INTERIM DIVIDEND**

The Board does not recommend any interim dividend for the six months ended June 30, 2025.

**OTHER INFORMATION**

**CORPORATE STRATEGY**

The primary objective of the Company is to be a leader in the discovery, development and commercialization of targeted therapies and immunotherapies for the treatment of cancer and immunological diseases. The strategy of the Company is to leverage the highly specialized expertise of the drug discovery division, the Oncology/Immunology operations, to develop and expand the drug candidate portfolio of the Group for the global market, building on the first-mover advantage in the development and launch of novel cancer medicines in China, and engaging partners for late-stage development and commercialization outside China. This strategy is aligned with the Company's culture of innovation and high engagement and empowerment of employees with a strong focus on reward and recognition. The Chairman's Statement and the Operations Review contain discussions and analyses of the Group's opportunities, performance and the basis on which the Group generates or preserves value over the longer term and the basis on which the Group will execute its strategy for delivering its objectives. The Group also focuses on sustainability and delivering business solutions to support the transition to a low-carbon economy. Further information on the sustainability initiatives of the Group and its key relationships with stakeholders can also be found in the standalone Sustainability Report of the Group.

**SUSTAINABILITY**

The key sustainability mission of the Group is to create long-term value for stakeholders by aligning its sustainability objectives to the strategic development of its businesses. The Board of Directors ("the Board") has the overall responsibility to ensure that sustainability issues are integrated into the operations, strategy and long-term development of the Group. It provides oversight of the sustainability performance of the Group through closely monitoring key sustainability matters and performance indicators, along with trends, risks, and opportunities that may impact the business development of the Group. Supported by the Sustainability Committee, senior management, and sustainability working groups, the Board oversees the management approach to sustainability matters and the formulation of sustainability strategies.

A standalone Sustainability Report of the Company for 2024 was published alongside the 2024 Annual Report in April 2025 and included further information on the Group's sustainability initiatives and their performance. It further discussed the abovementioned sustainability mission and strategies, management approach, progress of goals and targets, material quantitative data, as well as policies and key initiatives of the Group. Over the course of 2025, the Group continues to engage its stakeholders to identify areas for improvement in these sustainability fronts.

**HUMAN RESOURCES**

As at June 30, 2025, the Group employed approximately 1,780 (June 30, 2024: ~1,970) full time staff members. Staff costs for the six months ended June 30, 2025, including directors' emoluments, totaled $84.0 million (H1-24: $101.9 million).

The Group fully recognizes the importance of high-quality employees in sustaining market leadership. Salary and benefits are kept at competitive levels, while individual performance is rewarded within the general framework of the salary, bonus and incentive system of the Group, which is reviewed annually. Employees are provided with a wide range of benefits that include medical coverage, provident funds and retirement plans, and long-service awards. The Group stresses the importance of staff development and provides training programs on an ongoing basis. Employees are also encouraged to play an active role in community care activities.

**PURCHASE, SALE OR REDEMPTION OF LISTED SECURITIES**

During the period from January 1, 2025 to June 30, 2025, neither the Company nor any of its subsidiaries has purchased, sold or redeemed any of the listed securities (including sale of treasury shares (within the meaning of the Hong Kong Listing Rules)) of the Company.

**COMPLIANCE WITH THE CORPORATE GOVERNANCE CODE**

The Company strives to attain and maintain high standards of corporate governance best suited to the needs and interests of the Company and its subsidiaries as it believes that effective corporate governance framework is fundamental to promoting and safeguarding interests of shareholders and other stakeholders and enhancing shareholder value. Accordingly, the Company has adopted and applied corporate governance principles and practices that emphasize a quality Board, effective risk management and internal control systems, stringent disclosure practices, transparency and accountability as well as effective communication and engagement with shareholders and other stakeholders. It is, in addition, committed to continuously enhancing these standards and practices and inculcating a robust culture of compliance and ethical governance underlying the business operations and practices across the Group.

The Company has complied throughout the six months ended June 30, 2025 with all applicable code provisions of the Hong Kong Corporate Governance Code contained in Part 2 of Appendix C1 of the Hong Kong Listing Rules, as in force during the reporting period.

**COMPLIANCE WITH THE SHARE DEALINGS CODE FOR SECURITIES TRANSACTIONS BY DIRECTORS**

The Board has adopted the Code on Dealings in Shares which is on terms no less exacting than the required standard set out in the Model Code for Securities Transactions by Directors of Listed Issuers set out in Appendix C3 of the Hong Kong Listing Rules as the code of conduct regulating Directors' dealings in securities of the Company. In response to specific enquiries made, all Directors have confirmed that they have complied with the required standards set out in such code regarding their securities transactions throughout their tenure during the six months ended June 30, 2025.

**REVIEW OF INTERIM UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS**

The interim unaudited condensed consolidated financial statements of the Group for the six months ended June 30, 2025 have been reviewed by the auditor of the Company, PricewaterhouseCoopers, in accordance with Hong Kong Standard on Review Engagements 2410 – "Review of Interim Financial Information Performed by the Independent Auditor of the Entity" issued by the Hong Kong Institute of Certified Public Accountants for the Hong Kong filing. The interim unaudited condensed consolidated financial statements of the Group for the six months ended June 30, 2025 have also been reviewed by the Audit Committee of the Company.

**IMPORTANT EVENTS AFTER THE REPORTING DATE**

Save as disclosed above, no important events affecting the Company occurred since June 30, 2025 and up to the date of this announcement.

**PUBLICATION OF INTERIM RESULTS AND INTERIM REPORT**

This interim results announcement is published on the websites of HKEX (www.hkexnews.hk), the London Stock Exchange (www.londonstockexchange.com), the US Securities and Exchange Commission (www.sec.gov) and the Company (www.hutch-med.com). The interim report of the Group for the six months ended June 30, 2025 will be published on the websites of HKEX and the Company in August 2025.

**GLOSSARY**

---

| | |
|:---|:---|
| *1L* | *First-line.* |
| *2L* | *Second-line.* |
| *3L* | *Third-line.* |
| *AACR* | *American Association for Cancer Research.* |
| *ADC* | *Antibody-drug conjugate.* |
| *ADS* | *American depositary shares, each of which represents five ordinary shares.* |
| *AIHA* | *Autoimmune hemolytic anemia.* |
| *AKT* | *Protein kinase B.* |
| *AML* | *Acute myeloid leukemia.* |
| *ASCO* | *American Society of Clinical Oncology.* |
| *ASH* | *American Society of Hematology.* |
| *AstraZeneca* | *AstraZeneca AB, a subsidiary of AstraZeneca plc.* |
| *ATTC* | *Antibody-targeted therapy conjugates.* |
| *BICR* | *Blinded independent central review.* |
| *BOC* | *Bank of China Limited.* |
| *BTK* | *Bruton's tyrosine kinase.* |
| *CDP Worldwide* | *formerly known as the Carbon Disclosure Project.* |
| *CER* | *Constant exchange rate. We also report changes in performance at CER which is a non-GAAP measure. Please refer to "Use of Non-GAAP Financial Measures and Reconciliation" for further information relevant to the interpretation of these financial measures and reconciliations of these financial measures to the most comparable GAAP measures.* |
| *CLL* | *Chronic lymphocytic leukemia.* |
| *CNS* | *Central nervous system.* |
| *CR+CRh* | *Combined complete remission + complete remission with partial hematologic recovery.* |
| *CRC* | *Colorectal cancer.* |
| *CSF-1R* | *Colony-stimulating factor 1 receptor.* |
| *DCR* | *Disease control rate.* |
| *DLBCL* | *Diffuse large B-cell lymphoma.* |
| *DoR* | *Duration of response.* |
| *EASI* | *Eczema area and severity index.* |
| *EGFR* | *Epidermal growth factor receptor.* |
| *EGFRm* | *Epidermal growth factor receptor mutated.* |
| *EHA* | *European Hematology Association.* |
| *ELCC* | *The European Lung Cancer Congress.* |
| *Eli Lilly* | *Lilly (Shanghai) Management Company Limited.* |
| *EMC* | *Endometrial cancer.* |
| *epNET* | *Extra-pancreatic neuroendocrine tumor.* |
| *Epizyme* | *Epizyme, Inc., an Ipsen company.* |
| *ERK* | *Extracellular signal-regulated kinase.* |
| *ESG* | *Environmental, Social and Governance.* |
| *ESMO* | *European Society for Medical Oncology.* |
| *EZH2* | *Enhancer of zeste homolog 2.* |
| *EZH2m* | *Enhancer of zeste homolog 2 mutated.* |
| *FPI* | *First patient in.* |
| *FDA* | *Food and Drug Administration.* |
| *FGFR* | *Fibroblast growth factor receptor.* |
| *FLT3* | *FMS-like tyrosine kinase 3.* |
| *GAAP* | *Generally Accepted Accounting Principles.* |
| *GC* | *Gastric cancer.* |
| *HR* | *Hazard Ratio.* |
| *Hainan Pilot Zone* | *Hainan Boao Lecheng International Medical Tourism Pilot Zone.* |
| *HKEX* | *The Main Board of The Stock Exchange of Hong Kong Limited.* |

---

---

| | |
|:---|:---|
| *ICML* | *International Conference on Malignant Lymphoma.* |
| *IDH1/2* | *Isocitrate dehydrogenase-1 OR isocitrate dehydrogenase-2.* |
| *IHCC* | *Intrahepatic cholangiocarcinoma.* |
| *IIT* | *Investigator-initiated trial.* |
| *IND* | *Investigational new drug application.* |
| *Inmagene* | *Inmagene Biopharmaceuticals.* |
| *In-market sales* | *Total sales to third parties provided by Eli Lilly (ELUNATE*<sup>®</sup>*), Takeda (FRUZAQLA*<sup>®</sup>*), AstraZeneca (ORPATHYS*<sup>®</sup>*) and HUTCHMED (ELUNATE*<sup>®</sup>*, SULANDA*<sup>®</sup>*, ORPATHYS*<sup>®</sup> *and TAZVERIK*<sup>®</sup>*).* |
| *Ipsen* | *Ipsen SA, parent of Epizyme, Inc.* |
| *IRC* | *Independent review committee.* |
| *ITP* | *Immune thrombocytopenia purpura.* |
| *ITT* | *Intend-to-treat.* |
| *JAK* | *Janus kinase.* |
| *JAMA* | *Journal of the American Medical Association.* |
| *LPI* | *Last patient in.* |
| *LPR* | *Loan Prime Rate.* |
| *MAPK* | *Mitogen-activated protein kinase.* |
| *mDoR* | *median Duration of response.* |
| *MET* | *Mesenchymal epithelial transition factor.* |
| *METex14* | *MET exon 14 skipping alteration.* |
| *MLL* | *Mixed-lineage leukemia.* |
| *mOS* | *median Overall survival.* |
| *mPFS* | *median Progression-free survival.* |
| *MSS* | *Microsatellite stable.*  |
| *NDA* | *New Drug Application.* |
| *NET* | *Neuroendocrine tumor.* |
| *NHL* | *Non-Hodgkin lymphoma.* |
| *NHS* | *National Health Service in the United Kingdom.* |
| *NHSA* | *China National Healthcare Security Administration.* |
| *NMPA* | *China National Medical Products Administration.* |
| *NPM1* | *Nucleophosmin 1.* |
| *NRDL* | *China National Reimbursement Drug List.* |
| *NSCLC* | *Non-small cell lung cancer.* |
| *ORR* | *Objective response rate.* |
| *OS* | *Overall survival.* |
| *PBOC* | *People's Bank of China.* |
| *PD-1* | *Programmed cell death protein-1.* |
| *PDAC* | *Pancreatic ductal adenocarcinoma.* |
| *PFS* | *Progression free survival.* |
| *PI3K* | *Phosphatidylinositol 3-kinase.* |
| *PI3Kδ* | *Phosphoinositide 3-kinase-δ.* |
| *pMMR* | *Proficient mismatch repair.* |
| *pNET* | *Pancreatic neuroendocrine tumor.* |
| *PRCC* | *Papillary renal cell carcinoma.* |
| *PTCL* | *Peripheral T-cell lymphomas.* |
| *R/R* | *Relapsed and/or refractory.* |
| *RAS* | *Rat sarcoma.* |
| *RCC* | *Renal cell carcinoma.* |
| *RMB or "renminbi"* | *The legal currency of the PRC.* |
| *RP2D* | *The recommended phase 2 dose.* |
| *RP3D* | *The recommended phase 3 dose.* |
| *S&A* | *Selling and administrative expenses.* |
| *SHP2* | *SH2 containing protein tyrosine phosphatase-2.* |

---

---

| | | |
|:---|:---|:---|
| *SHPL* | *=* | *Shanghai Hutchison Pharmaceuticals Limited.* |
| *SLL* | *=* | *Small lymphocytic lymphoma.* |
| *sNDA* | *=* | *Supplemental New Drug Application.* |
| *STAT* | *=* | *Signal transducer and activator of transcription.* |
| *Syk* | *=* | *Spleen tyrosine kinase.* |
| *Takeda* | *=* | *Takeda Pharmaceuticals International AG, a subsidiary of Takeda Pharmaceutical Company Limited.* |
| *TEAE* | *=* | *Treatment emergent adverse events.* |
| *TKI* | *=* | *Tyrosine kinase inhibitor.* |
| *TPO* | *=* | *Thrombopoietin.* |
| *TPO-RA* | *=* | *Thrombopoietin receptor agonists.* |
| *TRAE* | *=* | *Treatment-related adverse events.* |
| *VEGFR* | *=* | *Vascular endothelial growth factor receptor.* |
| *wAIHA* | *=* | *Warm autoimmune haemolytic anaemia.* |
| *WCLC* | *=* | *World Conference on Lung Cancer.* |

---

**INTERIM UNAUDITED CONDENSED CONSOLIDATED**

**FINANCIAL STATEMENTS**

**HUTCHMED (CHINA) LIMITED**

**CONDENSED CONSOLIDATED BALANCE SHEETS**

**(IN US$'000, EXCEPT SHARE DATA)**

---

| | | | |
|:---|:---|:---|:---|
|  | <br>**Note** | **June 30,** <br>**2025** | **December 31,** <br>**2024** |
|  |  | **(Unaudited)** |  |
| **Assets** |  |  |  |
| Current assets |  |  |  |
| &nbsp;&nbsp;Cash and cash equivalents | 3 | 110719 | 153958 |
| &nbsp;&nbsp;Short-term investments | 3 | 1253801 | 682152 |
| &nbsp;&nbsp;Accounts receivable | 4 | 146967 | 155537 |
| &nbsp;&nbsp;Other receivables, prepayments and deposits | 5 | 21499 | 16609 |
| &nbsp;&nbsp;Amounts due from related parties | 17(ii) | 10887 | 7899 |
| &nbsp;&nbsp;Inventories | 6 | 48454 | 50400 |
| **Total current assets** |  | **1592327** | **1066555** |
| Property, plant and equipment |  | 94573 | 92498 |
| Investment in an equity investee | 7 | 3645 | 77765 |
| Investment in equity security |  | 5000 | 5000 |
| Amounts due from related parties | 17(ii) | 39775 |  |
| Other non-current assets |  | 40620 | 32378 |
| **Total assets** |  | **1775940** | **1274196** |
| **Liabilities and shareholders' equity** |  |  |  |
| Current liabilities |  |  |  |
| &nbsp;&nbsp;Accounts payable | 8 | 43725 | 42521 |
| &nbsp;&nbsp;Other payables, accruals and advance receipts | 9 | 221061 | 256124 |
| &nbsp;&nbsp;Short-term bank borrowings | 10 | 25603 | 23372 |
| &nbsp;&nbsp;Deferred revenue | 14 | 46843 | 50071 |
| &nbsp;&nbsp;Other current liabilities |  | 5117 | 4474 |
| **Total current liabilities** |  | **342349** | **376562** |
| Long-term bank borrowings | 10 | 67841 | 59434 |
| Deferred revenue, non-current portion | 14 | 30785 | 48432 |
| Other non-current liabilities | 11 | 93042 | 17915 |
| **Total liabilities** |  | **534017** | **502343** |
| Commitments and contingencies | 12 |  |  |
| **Company's shareholders' equity** |  |  |  |
| &nbsp;&nbsp;Ordinary shares; $0.10 par value; 1,500,000,000 shares authorized; 872,111,470 and 871,601,095 shares issued at June 30, 2025 and December 31, 2024 |  | 87211 | 87160 |
| &nbsp;&nbsp;Additional paid-in capital |  | 1527662 | 1517526 |
| &nbsp;&nbsp;Accumulated losses |  | (380319) | (833172) |
| &nbsp;&nbsp;Accumulated other comprehensive loss |  | (5490) | (11585) |
| **Total Company's shareholders' equity** |  | **1229064** | **759929** |
| Non-controlling interests |  | 12859 | 11924 |
| **Total shareholders' equity** |  | **1241923** | **771853** |
| **Total liabilities and shareholders' equity** |  | **1775940** | **1274196** |

---

The accompanying notes are an integral part of these interim unaudited condensed consolidated financial statements.

**HUTCHMED (CHINA) LIMITED**

**CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS**

**(UNAUDITED, IN US$'000, EXCEPT SHARE AND PER SHARE DATA)**

---

| | | | |
|:---|:---|:---|:---|
|  | | **Six Months Ended June 30,**  | **Six Months Ended June 30,**  |
|  | <br>**Note** | **2025** | **2024** |
| **Revenue** |  |  |  |
| &nbsp;&nbsp;Goods —third parties |  | 199364 | 204574 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; —related parties | 17(i) | 727 | 2002 |
| &nbsp;&nbsp;Services —commercialization—third parties |  | 19985 | 28222 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; —research and development—related parties | 17(i) |  | 236 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; —collaboration research and development—third parties |  | 14201 | 35740 |
| &nbsp;&nbsp;Other collaboration revenue |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; —royalties—third parties |  | 31310 | 34907 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; —licensing—third parties |  | 12090 |  |
| **Total revenue** | 14 | **277677** | **305681** |
| **Operating expenses** |  |  |  |
| &nbsp;&nbsp;Cost of goods—third parties |  | (147601) | (151681) |
| &nbsp;&nbsp;Cost of goods—related parties |  | (391) | (987) |
| &nbsp;&nbsp;Cost of services—commercialization—third parties |  | (19585) | (27467) |
| &nbsp;&nbsp;Research and development expenses | 15 | (71990) | (95256) |
| &nbsp;&nbsp;Selling expenses |  | (13873) | (27351) |
| &nbsp;&nbsp;Administrative expenses |  | (27751) | (30460) |
| **Total operating expenses** |  | **(281191)** | **(333202)** |
|  |  | **(3514)** | **(27521)** |
| Gain on divestment of an equity investee | 16 | 477456 |  |
| Other income, net |  | 21650 | 22765 |
| **Income/(loss) before income taxes and equity in earnings of an equity investee** |  | **495592** | **(4756)** |
| Income tax expense | 18 | (63162) | (2886) |
| Equity in earnings of an equity investee, net of tax | 7 | 23125 | 33807 |
| **Net income** |  | **455555** | **26165** |
| Less: Net income attributable to non-controlling interests |  | (601) | (364) |
| **Net income attributable to the Company** |  | **454954** | **25801** |
| Earnings per share attributable to the Company (US$ per share) |  |  |  |
| &nbsp;&nbsp;—basic | 19 | 0.53 | 0.03 |
| &nbsp;&nbsp;—diluted | 19 | 0.52 | 0.03 |
| Number of shares used in per share calculation |  |  |  |
| &nbsp;&nbsp;—basic | 19 | 857038725 | 856030704 |
| &nbsp;&nbsp;—diluted | 19 | 872564513 | 872534466 |

---

The accompanying notes are an integral part of these interim unaudited condensed consolidated financial statements.

**HUTCHMED (CHINA) LIMITED**

**CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME**

**(UNAUDITED, IN US$'000)**

---

| | | |
|:---|:---|:---|
|  | **Six Months Ended June 30,**  | **Six Months Ended June 30,**  |
|  | **2025** | **2024** |
| **Net income** | **455555** | **26165** |
| Other comprehensive income/(loss) |  |  |
| &nbsp;&nbsp;Foreign currency translation gain/(loss) | 1318 | (1590) |
| **Total comprehensive income** | **456873** | **24575** |
| Less: Comprehensive income attributable to non-controlling interests | (931) | (145) |
| **Total comprehensive income attributable to the Company** | **455942** | **24430** |

---

The accompanying notes are an integral part of these interim unaudited condensed consolidated financial statements.

**HUTCHMED (CHINA) LIMITED**

**CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN SHAREHOLDERS' EQUITY**

**(UNAUDITED, IN US$'000, EXCEPT SHARE DATA IN '000)**

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
|  | <br>**Ordinary**<br>**Shares**<br>**Number** | <br>**Ordinary**<br>**Shares**<br>**Value** | <br>**Additional**<br>**Paid-in**<br>**Capital** | <br>**Accumulated**<br>**Losses** | **Accumulated**<br>**Other**<br>**Comprehensive**<br>**Loss** | **Total**<br>**Company's**<br>**Shareholders'**<br>**Equity** | <br>**Non-**<br>**controlling**<br>**Interests** | <br>**Total**<br>**Shareholders'**<br>**Equity** |
| **As at January 1, 2024** | **871256** | **87126** | **1522447** | **(870869)** | **(8163)** | **730541** | **12846** | **743387** |
| Net income |  |  |  | 25801 |  | 25801 | 364 | 26165 |
| Issuances in relation to share option exercises | 103 | 10 | 218 |  |  | 228 |  | 228 |
| Share-based compensation |  |  |  |  |  |  |  |  |
| &nbsp;&nbsp;Share options |  |  | 1429 |  |  | 1429 | 3 | 1432 |
| &nbsp;&nbsp;Long-term incentive plan ("LTIP") |  |  | 19520 |  |  | 19520 | (60) | 19460 |
|  |  |  | 20949 |  |  | 20949 | (57) | 20892 |
| LTIP—treasury shares acquired and held by Trustee |  |  | (36064) |  |  | (36064) |  | (36064) |
| Dividend declared to a non-controlling shareholder of a subsidiary |  |  |  |  |  |  | (1000) | (1000) |
| Foreign currency translation adjustments |  |  |  |  | (1371) | (1371) | (219) | (1590) |
| **As at June 30, 2024** | **871359** | **87136** | **1507550** | **(845068)** | **(9534)** | **740084** | **11934** | **752018** |
| **As at January 1, 2025** | **871601** | **87160** | **1517526** | **(833172)** | **(11585)** | **759929** | **11924** | **771853** |
| Net income |  |  |  | 454954 |  | 454954 | 601 | 455555 |
| Issuances in relation to share option exercises | 510 | 51 | 1049 |  |  | 1100 |  | 1100 |
| Share-based compensation |  |  |  |  |  |  |  |  |
| &nbsp;&nbsp;Share options |  |  | 1549 |  |  | 1549 | 3 | 1552 |
| &nbsp;&nbsp;LTIP |  |  | 7811 |  |  | 7811 | 1 | 7812 |
|  |  |  | 9360 |  |  | 9360 | 4 | 9364 |
| Divestment of an equity investee (Note 16) |  |  | (2374) |  | 5107 | 2733 |  | 2733 |
| Transfer between reserves |  |  | 2101 | (2101) |  |  |  |  |
| Foreign currency translation adjustments |  |  |  |  | 988 | 988 | 330 | 1318 |
| **As at June 30, 2025** | **872111** | **87211** | **1527662** | **(380319)** | **(5490)** | **1229064** | **12859** | **1241923** |

---

The accompanying notes are an integral part of these interim unaudited condensed consolidated financial statements.

**HUTCHMED (CHINA) LIMITED**

**CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS**

**(UNAUDITED, IN US$'000)**

---

| | | | |
|:---|:---|:---|:---|
|  | | **Six Months Ended June 30,**  | **Six Months Ended June 30,**  |
|  | <br>**Note** | **2025** | **2024** |
| Net cash used in operating activities | 21 | (72894) | (39832) |
| **Investing activities** |  |  |  |
| Purchases of property, plant and equipment |  | (9267) | (10108) |
| Proceeds from disposal of property, plant and equipment |  | 6 |  |
| Refund of leasehold land deposit |  |  | 426 |
| Deposits in short-term investments |  | (1301767) | (991056) |
| Proceeds from short-term investments |  | 730118 | 995303 |
| Proceeds from divestment of an equity investee | 16 | 608503 |  |
| Acquisition of an intangible asset | 20(i) | (10000) |  |
| Net cash generated from/(used in) investing activities |  | 17593 | (5435) |
| **Financing activities** |  |  |  |
| Proceeds from issuances of ordinary shares | 13(i) | 1100 | 228 |
| Purchases of treasury shares | 13(ii) |  | (36064) |
| Dividend paid to a non-controlling shareholder of a subsidiary | 17(iii) |  | (1000) |
| Proceeds from bank borrowings |  | 8221 | 8466 |
| Repayment of bank borrowings |  |  | (4192) |
| Net cash generated from/(used in) financing activities |  | 9321 | (32562) |
| Net decrease in cash and cash equivalents |  | (45980) | (77829) |
| Effect of exchange rate changes on cash and cash equivalents |  | 2741 | (1807) |
|  |  | (43239) | (79636) |
| **Cash and cash equivalents** |  |  |  |
| Cash and cash equivalents at beginning of period |  | 153958 | 283589 |
| Cash and cash equivalents at end of period |  | 110719 | 203953 |

---

The accompanying notes are an integral part of these interim unaudited condensed consolidated financial statements.

**HUTCHMED (CHINA) LIMITED**

**NOTES TO THE INTERIM UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS**

**1. Organization and Nature of Business**

HUTCHMED (China) Limited (the "Company") and its subsidiaries (together the "Group") are principally engaged in researching, developing, manufacturing and marketing pharmaceutical products. The Group has research and development facilities and manufacturing plants in the People's Republic of China (the "PRC") and sell its products mainly in the PRC, including Hong Kong and Macau. In addition, the Group has established international operations in the United States of America (the "US") and Europe.

The Company's ordinary shares are listed on the Main Board of The Stock Exchange of Hong Kong Limited and the AIM market of the London Stock Exchange, and its American depositary shares ("ADS") are traded on the Nasdaq Global Select Market ("NASDAQ").

***Liquidity***

As at June 30, 2025, the Group had accumulated losses of US$380,319,000 primarily due to its spending in drug research and development activities. The Group regularly monitors current and expected liquidity requirements to ensure that it maintains sufficient cash balances and adequate credit facilities to meet its liquidity requirements in the short and long term. As at June 30, 2025, the Group had cash and cash equivalents of US$110,719,000, short-term investments of US$1,253,801,000 and unutilized bank borrowing facilities of US$53,969,000. Short-term investments comprised of bank deposits maturing over three months.

Based on the Group's operating plan, the existing cash and cash equivalents, short-term investments and unutilized bank borrowing facilities are considered to be sufficient to meet the cash requirements to fund planned operations and other commitments for at least the next twelve months from the issuance date of the interim unaudited condensed consolidated financial statements.

**2. Summary of Significant Accounting Policies**

***Basis of Presentation***

The interim unaudited condensed consolidated financial statements have been prepared in conformity with generally accepted accounting principles in the United States of America ("US GAAP") for interim financial information. Accordingly, they do not include all of the information and footnotes required by US GAAP for complete financial statements. The interim unaudited condensed consolidated financial statements have been prepared on the same basis as the annual audited consolidated financial statements. In the opinion of management, all adjustments, consisting of normal recurring adjustments necessary for the fair statement of results for the periods presented, have been included. The results of operations of any interim period are not necessarily indicative of the results of operations for the full year or any other interim period.

The comparative year-end condensed balance sheet data was derived from the annual audited consolidated financial statements, but is condensed to the same degree as the interim condensed balance sheet data.

The interim unaudited condensed consolidated financial statements and related disclosures have been prepared with the presumption that users have read or have access to the annual audited consolidated financial statements for the preceding fiscal year.

The preparation of interim unaudited condensed consolidated financial statements in conformity with US GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the interim unaudited condensed consolidated financial statements and the reported amounts of revenue and expenses during the reporting period.

***Recent Accounting Pronouncements***

Amendments that have been issued by the Financial Accounting Standards Board or other standards-setting bodies that do not require adoption until a future date are not expected to have a material impact on the Group's condensed consolidated financial statements.

**3. Cash and Cash Equivalents and Short-term Investments**

---

| | | |
|:---|:---|:---|
|  | **June 30,** <br>**2025** | **December 31,**<br>**2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| **Cash and Cash Equivalents** |  |  |
| &nbsp;&nbsp;Cash at bank and on hand  | 67300 | 84480 |
| &nbsp;&nbsp;Bank deposits maturing in three months or less  | 43419 | 69478 |
|  | 110719 | 153958 |
| **Short-term Investments**  |  |  |
| &nbsp;&nbsp;Bank deposits maturing over three months (note) | 1253801 | 682152 |
|  | 1364520 | 836110 |

---

Note: The maturities for short-term investments ranged from 91 to 186 days for each of the six months ended June 30, 2025 and the year ended December 31, 2024.

Certain cash and bank balances denominated in Renminbi ("RMB"), US dollar ("US$") and UK Pound Sterling ("£") were deposited with banks in the PRC. The conversion of these balances into foreign currencies is subject to the rules and regulations of foreign exchange control promulgated by the PRC government. Cash and cash equivalents and short-term investments were denominated in the following currencies:

---

| | |
|:---|:---|
| **June 30,**<br>**2025** | **December 31,**<br>**2024** |
| **(in US$'000)** | **(in US$'000)** |
| 1337598 | 795566 |
| 25617 | 37906 |
| 1148 | 2396 |
| £110 | 212 |
| 47 | 30 |
| 1364520 | 836110 |

---

**4. Accounts Receivable**

Accounts receivable from contracts with customers consisted of the following:

---

| | | |
|:---|:---|:---|
|  | **June 30,**<br>**2025** | **December 31,** <br>**2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Accounts receivable—third parties | 146607 | 155155 |
| Accounts receivable—related parties (Note 17(ii)) | 405 | 452 |
| Allowance for credit losses | (45) | (70) |
| Accounts receivable, net | 146967 | 155537 |

---

Substantially all accounts receivable are denominated in RMB, US$ and HK$ and are due within one year from the end of the reporting periods. The carrying values of accounts receivable approximate their fair values due to their short-term maturities.

An aging analysis for accounts receivable—third parties based on the relevant invoice dates is as follows:

---

| | | |
|:---|:---|:---|
|  | **June 30,** <br>**2025** | **December 31,** <br>**2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Not later than 3 months | 123548 | 138695 |
| Between 3 months to 6 months | 15782 | 9914 |
| Between 6 months to 1 year | 6071 | 5418 |
| Later than 1 year | 1206 | 1128 |
| Accounts receivable—third parties | 146607 | 155155 |

---

Movements on the allowance for credit losses:

---

| | | |
|:---|:---|:---|
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| As at January 1 | 70 | 171 |
| Increase in allowance for credit losses | 42 | 25 |
| Decrease in allowance due to subsequent collection  | (68) | (168) |
| Exchange difference | 1 | (3) |
| As at June 30 | 45 | 25 |

---

**5. Other Receivables, Prepayments and Deposits**

Other receivables, prepayments and deposits consisted of the following:

---

| | | |
|:---|:---|:---|
|  | **June 30,** <br>**2025** | **December 31,** <br>**2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Prepayments | 11556 | 7924 |
| Interest receivables | 5289 | 2741 |
| Value-added tax receivables | 1810 | 3297 |
| Deposits | 1125 | 1081 |
| Others  | 1719 | 1566 |
|  | 21499 | 16609 |

---

No allowance for credit losses has been made for other receivables, prepayments and deposits for the six months ended June 30, 2025 and the year ended December 31, 2024.

**6. Inventories**

Inventories, net of provision for excess and obsolete inventories, consisted of the following:

---

| | | |
|:---|:---|:---|
|  | **June 30,** <br>**2025** | **December 31,** <br>**2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Raw materials | 24430 | 24349 |
| Finished goods | 24024 | 26051 |
|  | 48454 | 50400 |

---

**7. Investment in an Equity Investee**

Investment in an equity investee consisted of the following:

---

| | | |
|:---|:---|:---|
|  | **June 30,** <br>**2025** | **December 31,** <br>**2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Shanghai Hutchison Pharmaceuticals Limited ("SHPL") (note) | 3645 | 77765 |

---

Note: SHPL is a private company with no quoted market price available for its shares.

On April 25, 2025, the group completed its transactions to divest 45% of its 50% shareholding in SHPL (Note 16).

Summarized financial information for SHPL is as follows:

&nbsp;&nbsp;&nbsp;&nbsp;**(i)** **Summarized balance sheets** 

---

| | | |
|:---|:---|:---|
|  | **June 30,** <br>**2025** | **December 31,** <br>**2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Current assets | 215248 | 213707 |
| Non-current assets | 65629 | 67561 |
| Current liabilities | (210965) | (126154) |
| Non-current liabilities | (5890) | (3858) |
| Net assets | 64022 | 151256 |

---

&nbsp;&nbsp;&nbsp;&nbsp;**(ii)** **Summarized statements of operations** 

---

| | | |
|:---|:---|:---|
|  | **Six Months Ended June 30,** | **Six Months Ended June 30,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Revenue | 233326 | 225208 |
| Gross profit | 173127 | 166758 |
| Interest income | 493 | 338 |
| Profit before taxation | 81754 | 80213 |
| Income tax expense (note (a)) | (12577) | (12294) |
| Net income (note (b)) | 69177 | 67919 |

---

Notes:

&nbsp;&nbsp;&nbsp;&nbsp;(a) The main entity within the SHPL group has been granted the High and New Technology Enterprise status. Accordingly, the entity was eligible to use a preferential income tax rate of 15% for the six months ended June 30, 2025 and 2024.

&nbsp;&nbsp;&nbsp;&nbsp;(b) Net income is before elimination of unrealized profits on transactions with the Group. The amounts eliminated were approximately US$584,000 and US$152,000 for the six months ended June 30, 2025 and 2024 respectively.

&nbsp;&nbsp;&nbsp;&nbsp;**(iii)** **Reconciliation of summarized financial information** 

Reconciliation of the summarized financial information presented to the carrying amount of investment in an equity investee is as follows:

---

| | | |
|:---|:---|:---|
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Opening net assets as at January 1 | 151256 | 91628 |
| Net income  | 69177 | 67919 |
| Dividend declared | (157274) |  |
| Deemed distribution |  | (690) |
| Other comprehensive income/(loss) | 863 | (2573) |
| Closing net assets as at June 30 | 64022 | 156284 |
| Group's share of net assets | 3201 | 78142 |
| Discounting on dividend payable | 212 |  |
| Goodwill | 279 | 2744 |
| Elimination of unrealized profits on downstream sales | (47) | (367) |
| Carrying amount of investment as at June 30 | 3645 | 80519 |

---

**8. Accounts Payable**

---

| | | |
|:---|:---|:---|
|  | **June 30,** <br>**2025** | **December 31,** <br>**2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Accounts payable—third parties | 43078 | 42521 |
| Accounts payable—related parties (Note 17(ii)) | 647 |  |
|  | 43725 | 42521 |

---

Substantially all accounts payable are denominated in RMB and US$ and are due within one year from the end of the reporting periods. The carrying values of accounts payable approximate their fair values due to their short-term maturities.

An aging analysis for accounts payable - third parties based on the relevant invoice dates is as follows:

---

| | | |
|:---|:---|:---|
|  | **June 30,** <br>**2025** | **December 31,** <br>**2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Not later than 3 months | 37946 | 37805 |
| Between 3 months to 6 months | 2972 | 2638 |
| Between 6 months to 1 year | 1081 | 833 |
| Later than 1 year | 1079 | 1245 |
| Accounts payable—third parties | 43078 | 42521 |

---

**9. Other Payables, Accruals and Advance Receipts**

Other payables, accruals and advance receipts consisted of the following:

---

| | | |
|:---|:---|:---|
|  | **June 30,** <br>**2025** | **December 31,** <br>**2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Accrued research and development expenses | 137621 | 153978 |
| Accrued administrative and other general expenses | 22306 | 14046 |
| Accrued salaries and benefits | 20380 | 29751 |
| Accrued capital expenditures  | 11751 | 15858 |
| Accrued selling and marketing expenses | 8352 | 14705 |
| Deferred government grants | 2042 | 6004 |
| Amounts due to related parties (Note 17(ii)) | 2002 | 2016 |
| Deposits | 1599 | 1627 |
| Provision for profit guarantee – current portion (Note 16) | 3105 |  |
| Others | 11903 | 18139 |
|  | 221061 | 256124 |

---

**10. Bank Borrowings**

Bank borrowings consisted of the following:

---

| | | |
|:---|:---|:---|
|  | **June 30,** <br>**2025** | **December 31,** <br>**2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Current | 25603 | 23372 |
| Non-current | 67841 | 59434 |
|  | 93444 | 82806 |

---

The weighted average interest rate for outstanding bank borrowings for the six months ended June 30, 2025 and the year ended December 31, 2024 was 2.89% per annum and 3.02% per annum respectively. The carrying amounts of the Group's outstanding bank borrowings as at June 30, 2025 and December 31, 2024 were denominated in RMB.

**(i) Short-term working capital loan facility**

In October 2024, a subsidiary entered into a short-term unsecured working capital loan facility with a bank in the amount of US$41,923,000 (RMB300,000,000) with an annual interest rate at the 1-year China Loan Prime Rate ("LPR") less 0.82%. As at June 30, 2025 and December 31, 2024, US$22,795,000 (RMB163,119,000) and US$22,167,000 (RMB163,119,000) were drawn from the facility respectively.

**(ii) 10-year fixed asset loan facility**

In October 2021, a subsidiary entered into a 10-year fixed asset loan facility agreement with the bank for the provision of a secured credit facility in the amount of US$105,490,000 (RMB754,880,000) with an annual interest rate at the 5-year China LPR less 0.8% (which was supplemented in June 2022) and interest payments commencing upon completion of the underlying construction in progress. This credit facility is guaranteed by the immediate holding company of the subsidiary and secured by the underlying leasehold land and buildings (Shanghai manufacturing facility). As at June 30, 2025 and December 31, 2024, US$70,649,000 (RMB505,556,000) and US$60,639,000 (RMB446,212,000) were utilized from the fixed asset loan facility respectively.

For the six months ended June 30, 2025, no interest was capitalized (For the year ended December 31, 2024: US$44,000).

The Group's bank borrowings are repayable as from the dates indicated as follows:

---

| | | |
|:---|:---|:---|
|  | **June 30,** <br>**2025** | **December 31,** <br>**2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Not later than 1 year | 25603 | 23372 |
| Between 1 to 3 years | 8423 | 6426 |
| Between 3 to 4 years | 14038 | 8033 |
| Between 4 to 5 years | 14038 | 12049 |
| Later than 5 years | 31342 | 32926 |
|  | 93444 | 82806 |

---

As at June 30, 2025 and December 31, 2024, the Group had aggregate unutilized bank borrowing facilities of US$53,969,000 and US$60,549,000 respectively.

**11. Other Non-current Liabilities**

Other non-current liabilities consisted of the following:

---

| | | |
|:---|:---|:---|
|  | **June 30, 2025** | **December 31, 2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Provision for profit guarantee, non-current portion (Note 16) | 75980 |  |
| Branding liability payable (Note 17 (ii)) | 6650 | 6475 |
| Lease liabilities | 3109 | 4089 |
| Others | 7303 | 7351 |
|  | 93042 | 17915 |

---

**12. Commitments and Contingencies**

The Group had the following capital commitments:

---

| | |
|:---|:---|
|  | **June 30,**<br>**2025** |
|  | **(in US$'000)** |
| Property, plant and equipment |  |
| &nbsp;&nbsp;Contracted but not provided for | 1430 |

---

The Group does not have any other significant commitments or contingencies.

**13. Share-based Compensation**

**(i) Share-based Compensation of the Company**

The Company conditionally adopted a share option scheme on April 24, 2015 (as amended on April 27, 2020) (the "HUTCHMED Share Option Scheme"). Pursuant to the HUTCHMED Share Option Scheme, the Board of Directors of the Company may, at its discretion, offer any employees and directors (including Executive and Non-executive Directors but excluding Independent Non-executive Directors) of the Company, holding companies of the Company and any of their subsidiaries or affiliates, and subsidiaries or affiliates of the Company share options to subscribe for shares of the Company.

As at June 30, 2025, the aggregate number of shares issuable under the HUTCHMED Share Option Scheme was 40,183,238 ordinary shares. The Company will issue new shares to satisfy share option exercises. Additionally, the number of shares authorized but unissued was 627,888,530 ordinary shares.

Share options granted are generally subject to a four-year vesting schedule, depending on the nature and the purpose of the grant. Share options subject to the four-year vesting schedule, in general, vest 25% upon the first anniversary of the vesting commencement date as defined in the grant letter, and 25% every subsequent year. However, certain share option grants may have a different vesting schedule as approved by the Board of Directors of the Company. No outstanding share options will be exercisable or subject to vesting after the expiry of a maximum of ten years from the date of grant.

A summary of the Company's share option activity and related information is as follows:

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | <br>**Number of share**<br>**options** | **Weighted**<br>**average exercise**<br>**price in US$ per** <br>**share** | **Weighted average**<br>**remaining**<br>**contractual life**<br>**(years)** | <br>**Aggregate**<br>**intrinsic value**<br>**(in US$'000)** |
| **Outstanding at January 1, 2024** | 29536655 | 4.57 | 6.67 | 9924 |
| Granted (note (a)) | 2965328 | 3.69 |  |  |
| Exercised | (344825) | 2.29 |  |  |
| Cancelled | (892600) | 4.38 |  |  |
| Expired | (1624285) | 5.23 |  |  |
| **Outstanding at December 31, 2024** | 29640273 | 4.47 | 5.99 | 3804 |
| Granted (note (b)) | 1493435 | 3.27 |  |  |
| Exercised | (510375) | 2.16 |  |  |
| Cancelled | (935775) | 2.18 |  |  |
| Expired | (1637050) | 5.55 |  |  |
| **Outstanding at June 30, 2025** | 28050508 | 4.46 | 5.70 | 3430 |
| **Vested and exercisable at December 31, 2024** | 21186120 | 4.92 | 5.13 | 1387 |
| **Vested and exercisable at June 30, 2025** | 21357920 | 4.84 | 4.80 | 2158 |

---

Notes:

&nbsp;&nbsp;&nbsp;&nbsp;(a) Includes aggregate 2,765,328 share options granted to an executive director. 1,359,561 share options were granted in March 2024 and 1,405,767 share options were granted in August 2024 where the number of share options exercisable is subject to certain performance targets based on a market condition covering the 3-year periods from 2023 to 2025 and from 2024 to 2026 respectively which has been reflected in estimating the grant date fair value using the Monte Carlo simulation model. The grant date fair value of such awards are US$1.29 and US$1.24 per share respectively. Vesting of such awards will occur around March 2026 and March 2027 respectively if the performance targets are met.

&nbsp;&nbsp;&nbsp;&nbsp;(b) This was granted to an executive director in June 2025 where the number of share options exercisable is subject to certain performance targets based on a market condition covering the 3-year period from 2025 to 2027 which has been reflected in estimating the grant date fair value. The grant date fair value of such award is US$1.17 per share using the Monte Carlo simulation model. Vesting of such award will occur around March 2028 if the performance targets are met.

In estimating the fair value of share options granted, the following assumptions were used in the Monte Carlo simulation model for the awards that are subject to certain performance targets based on a market condition and Polynomial model for other options granted in the periods indicated:

---

| | | |
|:---|:---|:---|
|  | **Six Months Ended**<br>**June 30, 2025** | **Year Ended**<br>**December 31, 2024** |
| Weighted average grant date fair value of share options (in US$ per share) | 1.17 | 1.29 |
| Significant inputs into the valuation model (weighted average): |  |  |
| &nbsp;&nbsp;Exercise price (in US$ per share) | 3.27 | 3.69 |
| &nbsp;&nbsp;Share price at effective date of grant (in US$ per share) | 3.27 | 3.69 |
| &nbsp;&nbsp;Expected volatility (note (a)) | 56.62% | 54.69% |
| &nbsp;&nbsp;Risk-free interest rate (note (b)) | 4.52% | 3.86% |
| &nbsp;&nbsp;Contractual life of share options (in years) | 10 | 10 |
| &nbsp;&nbsp;Expected dividend yield (note (c)) | 0% | 0% |

---

Notes:

&nbsp;&nbsp;&nbsp;&nbsp;(a) The Company calculated its expected volatility with reference to the historical volatility prior to the issuances of share options.

&nbsp;&nbsp;&nbsp;&nbsp;(b) The risk-free interest rates reference the US Treasury yield curves.

&nbsp;&nbsp;&nbsp;&nbsp;(c) The Company has not declared or paid any dividends and does not currently expect to do so prior to the exercise of the granted share options, and therefore uses an expected dividend yield of zero in the valuation models.

The Company will issue new shares to satisfy share option exercises. The following table summarizes the Company's share option exercises:

---

| | | |
|:---|:---|:---|
|  | **Six Months Ended June 30,**  | **Six Months Ended June 30,**  |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Cash received from share option exercises | 1100 | 228 |
| Total intrinsic value of share option exercises | 526 | 161 |

---

The Group recognizes compensation expense over the requisite service period. The following table presents share-based compensation expense included in the Group's condensed consolidated statements of operation:

---

| | | |
|:---|:---|:---|
|  | **Six Months Ended June 30,**  | **Six Months Ended June 30,**  |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Research and development expenses | 1206 | 801 |
| Selling and administrative expenses | 281 | 597 |
| Cost of revenue | 65 | 34 |
|  | 1552 | 1432 |

---

As at June 30, 2025, the total unrecognized compensation cost was US$4,268,000 and will be recognized over the weighted average remaining service period of 1.95 years.

**(ii) LTIP**

The Company grants awards under the LTIP to participating directors and employees, giving them a conditional right to receive ordinary shares of the Company or the equivalent ADS (collectively the "Awarded Shares") to be purchased by the Trustee up to a cash amount excluding any cash elected payments. Vesting will depend upon continued employment of the award holder with the Group and will otherwise be at the discretion of the Board of Directors of the Company. Additionally, some awards are subject to change based on annual performance targets prior to their determination date.

*LTIP awards prior to the determination date*

Performance targets vary by award, and may include targets for shareholder returns, revenue and net income/(loss) after taxes. As the extent of achievement of the performance targets is uncertain prior to the determination date, a probability based on management's assessment on the achievement of the performance targets has been assigned to calculate the amount to be recognized as an expense over the requisite period with a corresponding entry to liability.

*LTIP awards after the determination date*

Upon the determination date, based on the actual achievement of performance targets, the amount previously recorded in the liability will be adjusted through share-based compensation expense. The Company will pay a determined monetary amount, up to the maximum cash amount based on the actual achievement of the performance targets specified in the award, to the Trustee to purchase the Awarded Shares. Any cumulative compensation expense previously recognized as a liability will be transferred to additional paid-in capital.

Granted awards under the LTIP are as follows:

---

| | | | |
|:---|:---|:---|:---|
| <br>**Grant date** | **Maximum cash amount**<br>**(in US$ millions)** | **Covered**<br>**financial years** | **Performance targets**<br>**determination date** |
| March 13, 2024 | 0.7 | note (a) | note (a) |
| August 5, 2024 | 19.3 | 2024-2026 | note (b) |
| August 5, 2024 | 0.3 | note (c) | note (c) |
| June 9, 2025 | 20.0 | 2025-2027 | note (d) |

---

Notes:

&nbsp;&nbsp;&nbsp;&nbsp;(a) This award does not stipulate performance targets and is subject to a vesting schedule of 25% on each of the first, second, third and fourth anniversaries of the date of grant.

&nbsp;&nbsp;&nbsp;&nbsp;(b) The annual performance targets determination dates are the dates of the announcements of the Group's annual results for the financial years ending December 31, 2024, 2025 and 2026. Vesting occurs in 2027, three weeks after the date of completion of the share purchase for the awards for the financial year ending December 31, 2026.

&nbsp;&nbsp;&nbsp;&nbsp;(c) This award does not stipulate performance targets and is subject to a vesting schedule of 50% on the first and second anniversaries of the date of grant.

&nbsp;&nbsp;&nbsp;&nbsp;(d) The annual performance targets determination dates are the dates of the announcements of the Group's annual results for the financial years ending December 31, 2025, 2026 and 2027. Vesting occurs in 2028, three weeks after the date of completion of the share purchase for the awards for the financial year ending December 31, 2027.

The Trustee has been set up solely for the purpose of purchasing and holding the Awarded Shares during the vesting period on behalf of the Company using funds provided by the Company. On the determination date, if any, the Company will determine the cash amount, based on the actual achievement of each annual performance target, for the Trustee to purchase the Awarded Shares. The Awarded Shares will then be held by the Trustee until they are vested.

The Trustee's assets include treasury shares and funds for additional treasury shares, trustee fees and expenses. The number of treasury shares (in ordinary shares equivalent) held by the Trustee were as follows:

---

| | | |
|:---|:---|:---|
|  | **Number of**<br>**treasury shares** | **Cost**<br>**(in US$'000)** |
| As at January 1, 2024 | 17612685 | 66987 |
| Purchased | 10259133 | 36064 |
| Vested | (11154360) | (42127) |
| As at December 31, 2024 | 16717458 | 60924 |
| Vested | (3907180) | (14603) |
| As at June 30, 2025 | 12810278 | 46321 |

---

For the six months ended June 30, 2025 and 2024, US$2,086,000 and US$8,574,000 of the LTIP awards were forfeited respectively based on the determined or estimated monetary amount as at the forfeiture date.

The following table presents the share-based compensation expenses recognized under the LTIP awards:

---

| | | |
|:---|:---|:---|
|  | **Six Months Ended June 30,**  | **Six Months Ended June 30,**  |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Research and development expenses | 5491 | 6398 |
| Selling and administrative expenses | 1811 | 3203 |
| Cost of revenue | 389 | 279 |
|  | 7691 | 9880 |
| Recorded with a corresponding credit to: |  |  |
| Liability | 630 | 2844 |
| Additional paid-in capital | 7061 | 7036 |
|  | 7691 | 9880 |

---

For the six months ended June 30, 2025 and 2024, US$751,000 and US$12,424,000 were reclassified from liability to additional paid-in capital respectively upon LTIP awards reaching the determination date. As at June 30, 2025 and December 31, 2024, US$1,266,000 and US$1,443,000 were recorded in liabilities respectively.

As at June 30, 2025, the total unrecognized compensation cost was approximately US$14,833,000, which considers expected performance targets and the amounts expected to vest, and will be recognized over the requisite periods.

**14. Revenue**

The following table presents revenue disaggregated by contract type:

---

| | | | |
|:---|:---|:---|:---|
|  | **Six Months Ended June 30, 2025** | **Six Months Ended June 30, 2025** | **Six Months Ended June 30, 2025** |
|  | **Oncology/Immunology** | **Other Ventures** | **Total** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Invoiced Goods —Marketed Products  | 47744 |  | 47744 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;—Distribution |  | 134230 | 134230 |
| Services —Commercialization of Marketed Products | 19985 |  | 19985 |
| License & Collaborations —Services | 14201 |  | 14201 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;—Royalties | 31310 |  | 31310 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;—Licensing | 12090 |  | 12090 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;—Manufacturing supply | 18117 |  | 18117 |
|  | 143447 | 134230 | 277677 |
| Third parties | 143447 | 133503 | 276950 |
| Related parties (Note 17(i)) |  | 727 | 727 |
|  | 143447 | 134230 | 277677 |

---

---

| | | | |
|:---|:---|:---|:---|
|  | **Six Months Ended June 30, 2024** | **Six Months Ended June 30, 2024** | **Six Months Ended June 30, 2024** |
|  | **Oncology/Immunology** | **Other Ventures** | **Total** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Invoiced Goods —Marketed Products  | 64667 |  | 64667 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;—Distribution |  | 137044 | 137044 |
| Services —Commercialization of Marketed Products | 28222 |  | 28222 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;—Research and Development | 236 |  | 236 |
| License & Collaborations —Services | 35740 |  | 35740 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;—Royalties | 34907 |  | 34907 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;—Manufacturing supply | 4865 |  | 4865 |
|  | 168637 | 137044 | 305681 |
| Third parties | 168401 | 135042 | 303443 |
| Related parties (Note 17(i)) | 236 | 2002 | 2238 |
|  | 168637 | 137044 | 305681 |

---

The following table presents liability balances from contracts with customers:

---

| | | |
|:---|:---|:---|
|  | **June 30,**<br>**2025** | **December 31,**<br>**2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Deferred revenue |  |  |
| &nbsp;&nbsp;Current—Oncology/Immunology segment (note (a)) | 46541 | 50007 |
| &nbsp;&nbsp;Current—Other Ventures segment (note (b)) | 302 | 64 |
|  | 46843 | 50071 |
| &nbsp;&nbsp;Non-current—Oncology/Immunology segment (note (a)) | 30785 | 48432 |
| Total deferred revenue (note (c) and (d)) | 77628 | 98503 |

---

Notes:

&nbsp;&nbsp;&nbsp;&nbsp;(a) Oncology/Immunology segment deferred revenue relates to unamortized upfront and milestone payments, invoiced amounts for royalties where the customer has not yet completed the in-market sale and advance consideration received for cost reimbursements which are attributed to research and development services that have not yet been rendered as at the reporting date.

&nbsp;&nbsp;&nbsp;&nbsp;(b) Other Ventures segment deferred revenue relates to payments in advance from customers for goods that have not been transferred and services that have not been rendered to the customer as at the reporting date.

&nbsp;&nbsp;&nbsp;&nbsp;(c) Estimated deferred revenue to be recognized over time as from the date indicated is as follows:

---

| | | |
|:---|:---|:---|
|  | **June 30,**<br>**2025** | **December 31,**<br>**2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Not later than 1 year | 46843 | 50071 |
| Between 1 to 2 years | 20826 | 39288 |
| Between 2 to 3 years | 5337 | 4084 |
| Between 3 to 4 years | 966 | 1095 |
| Later than 4 years | 3656 | 3965 |
|  | 77628 | 98503 |

---

&nbsp;&nbsp;&nbsp;&nbsp;(d) As at January 1, 2025, deferred revenue was US$98.5 million, of which US$30.7 million was recognized during the six months ended June 30, 2025.

**15. Research and Development Expenses**

Research and development expenses are summarized as follows:

---

| | | |
|:---|:---|:---|
|  | **Six Months Ended June 30,**  | **Six Months Ended June 30,**  |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Clinical trial related costs | 38019 | 55728 |
| Personnel compensation and related costs | 30063 | 36858 |
| Other research and development expenses | 3908 | 2670 |
|  | 71990 | 95256 |

---

Research and development expenses include expenditures for collaborative arrangements under ASC 808 to evaluate the combination of the Group's drug compounds with the collaboration partners' drug compounds. For the six months ended June 30, 2025 and 2024, the Group has incurred research and development expenses of US$3.2 million and US$4.1 million respectively, related to such collaborative arrangements.

**16. Gain on Divestment of an Equity Investee**

On April 25, 2025, the Group completed the divestment of an aggregate 45% equity interest out of 50% in SHPL to third parties for cash consideration of US$608.5 million (RMB4.5 billion), including an aggregate 35% equity interest to two China-based private-equity funds ("PE Buyers") and 10% equity interest to the parent company of the existing 50% SHPL joint venture partner. In regard to the sales and purchase agreements with the PE Buyers, they include a profit guarantee clause with contingent payments capped at US$94.6 million (RMB696 million) based on growth targets for the 3 years up to 2027. As of the date of disposal, the Group recognized a provision for profit guarantee of US$75.8 million, which was the present value of the estimated profit guarantee to the PE Buyers. As at June 30, 2025, provision for profit guarantee was US$79,085,000 of which US$3,105,000 and US$75,980,000 were included in other payables and other non-current liabilities respectively and reflects interest accretion and foreign exchange. Any subsequent changes to estimated profit guarantee and accretion of the discount on the provision will be recognized in the gain on divestment of an equity investee.

The Group has the rights to nominate one director out of seven on SHPL's board of directors, thus the Group continues to have significant influence and accounts for its remaining 5% equity interest in SHPL using the equity method of accounting.

The gain on divestment of an equity investee was recognized in the condensed consolidated statement of operations as follows:

---

| | |
|:---|:---|
|  | **Six Months Ended June 30, 2025** |
|  | **(in US$'000)** |
| Proceeds | 608503 |
| Less: Provision for profit guarantee | (75829) |
| &nbsp;&nbsp;Interest accretion on provision for profit guarantee | (1110) |
| &nbsp;&nbsp;Carrying amount of 45% equity interest in SHPL | (48680) |
| &nbsp;&nbsp;Accumulated other comprehensive income and reserves | (2733) |
| &nbsp;&nbsp;Transaction costs and others | (2695) |
| Gain on divestment of an equity investee | 477456 |
| Less:Tax expenses | (61133) |
| Gain on divestment of an equity investee, net of tax | 416323 |

---

**17. Significant Transactions with Related Parties and Non-controlling Shareholders of Subsidiaries**

The Group has the following significant transactions with related parties and non-controlling shareholders of subsidiaries, which were carried out in the normal course of business at terms determined and agreed by the relevant parties:

&nbsp;&nbsp;&nbsp;&nbsp;**(i)** **Transactions with related parties:** 

---

| | | |
|:---|:---|:---|
|  | **Six Months Ended June 30,**  | **Six Months Ended June 30,**  |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Sales to: |  |  |
| &nbsp;&nbsp;Indirect subsidiaries of CK Hutchison Holdings Limited ("CK Hutchison") |  | 4 |
| &nbsp;&nbsp;An equity investee | 727 | 1998 |
|  | 727 | 2002 |
| Revenue from research and development services from: |  |  |
| &nbsp;&nbsp;An equity investee |  | 236 |
| Purchase from: |  |  |
| &nbsp;&nbsp;An equity investee | 1795 | 1452 |
| Rendering of management services from: |  |  |
| &nbsp;&nbsp;An indirect subsidiary of CK Hutchison | 519 | 535 |

---

&nbsp;&nbsp;&nbsp;&nbsp;**(ii)** **Balances with related parties included in:** 

---

| | | |
|:---|:---|:---|
|  | **June 30,** <br>**2025** | **December 31,** <br>**2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Accounts receivable—related parties |  |  |
| &nbsp;&nbsp;An equity investee (note (a)) | 405 | 452 |
| Amounts due from related parties |  |  |
| &nbsp;&nbsp;An equity investee (note (a) and (b)) | 50662 | 7899 |
| Accounts payable—related parties |  |  |
| &nbsp;&nbsp;An equity investee (note (a)) | 647 |  |
| Other payables, accruals and advance receipts |  |  |
| &nbsp;&nbsp;Indirect subsidiaries of CK Hutchison (note (c) and (e)) | 1929 | 1928 |
| &nbsp;&nbsp;An equity investee (note (a) and (d)) | 73 | 88 |
|  | 2002 | 2016 |
| Other non-current liabilities |  |  |
| &nbsp;&nbsp;An equity investee (note (d)) | 109 | 142 |
| &nbsp;&nbsp;An indirect subsidiary of CK Hutchison (note (e)) | 6650 | 6475 |
|  | 6759 | 6617 |

---

Notes:

&nbsp;&nbsp;&nbsp;&nbsp;(a) Balances with related parties are unsecured, repayable on demand and interest-free. The carrying values of balances with related parties approximate their fair values due to their short-term maturities, excluding non-current portion of the dividends receivable which has been discounted. No allowance for credit losses has been made for amounts due from related parties for the six months ended June 30, 2025 and the year ended December 31, 2024.

&nbsp;&nbsp;&nbsp;&nbsp;(b) As at June 30, 2025 and December 31, 2024, dividend receivable of US$50,002,000 and US$6,795,000 was included in amounts due from related parties respectively.

&nbsp;&nbsp;&nbsp;&nbsp;(c) Amounts due to indirect subsidiaries of CK Hutchison are unsecured, repayable on demand and interest-bearing if not settled within one month.

&nbsp;&nbsp;&nbsp;&nbsp;(d) Includes other deferred income representing amounts recognized from granting of commercial, promotion and marketing rights.

&nbsp;&nbsp;&nbsp;&nbsp;(e) As at June 30, 2025 and December 31, 2024, a branding liability payable of US$1,538,000 was included in amounts due to related parties under other payables, accruals and advance receipts. As at June 30, 2025 and December 31, 2024, US$6,650,000 and US$6,475,000 of the branding liability payable was included in other non-current liabilities respectively.

&nbsp;&nbsp;&nbsp;&nbsp;**(iii)** **Transactions with non-controlling shareholders of subsidiaries:** 

---

| | | |
|:---|:---|:---|
|  | **Six Months Ended June 30,**  | **Six Months Ended June 30,**  |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Sales | 26991 | 29395 |
| Purchases | 355 | 127 |
| Dividends declared |  | 1000 |
| Distribution service fee | 107 | 108 |

---

&nbsp;&nbsp;&nbsp;&nbsp;**(iv)** **Balances with non-controlling shareholders of subsidiaries included in:** 

---

| | | |
|:---|:---|:---|
|  | **June 30,** <br>**2025** | **December 31,** <br>**2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Accounts receivable | 7165 | 8084 |
| Accounts payable | 98 | 77 |
| Other payables, accruals and advance receipts | 327 | 427 |

---

**18. Income Taxes**

---

| | | |
|:---|:---|:---|
|  | **Six Months Ended June 30,**  | **Six Months Ended June 30,**  |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Current tax |  |  |
| &nbsp;&nbsp;HK | 1 | 1 |
| &nbsp;&nbsp;PRC | 62982 | 868 |
| &nbsp;&nbsp;US and others  | 26 | 86 |
| Total current tax | 63009 | 955 |
| Deferred income tax expense | 153 | 1931 |
| Income tax expense | 63162 | 2886 |

---

The reconciliation of the Group's reported income tax expense to the theoretical tax amount that would arise using the tax rates of the Company against the Group's income/(loss) before income taxes and equity in earnings of an equity investee is as follows:

---

| | | |
|:---|:---|:---|
|  | **Six Months Ended June 30,**  | **Six Months Ended June 30,**  |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Income/(loss) before income taxes and equity in earnings of an equity investee | 495592 | (4756) |
| Tax calculated at the statutory tax rate of the Company | 81773 | (785) |
| Tax effects of: |  |  |
| &nbsp;&nbsp;Different tax rates applicable in different jurisdictions | 2115 | 625 |
| &nbsp;&nbsp;Tax valuation allowance | 7783 | 6513 |
| &nbsp;&nbsp;Preferential tax rate difference | (865) | (32) |
| &nbsp;&nbsp;Preferential tax deduction and credits | (8348) | (8405) |
| &nbsp;&nbsp;Different tax rates applicable to gain from divestment of an equity investee | (17647) |  |
| &nbsp;&nbsp;Expenses not deductible for tax purposes | 5146 | 7548 |
| &nbsp;&nbsp;Utilization of previously unrecognized tax losses | (65) | (3) |
| &nbsp;&nbsp;Withholding tax on undistributed earnings of PRC entities | (66) | 1670 |
| &nbsp;&nbsp;Income not subject to tax | (5027) | (2852) |
| &nbsp;&nbsp;Temporary difference | (1762) | (1615) |
| &nbsp;&nbsp;Others | 125 | 222 |
| Income tax expense | 63162 | 2886 |

---

**19. Earnings Per Share**

**(i) Basic earnings per share**

Basic earnings per share is calculated by dividing net income attributable to the Company by the weighted average number of outstanding ordinary shares in issue during the period. Treasury shares held by the Trustee are excluded from the weighted average number of outstanding ordinary shares in issue for purposes of calculating basic earnings per share.

---

| | | |
|:---|:---|:---|
|  | **Six Months Ended June 30,**  | **Six Months Ended June 30,**  |
|  | **2025** | **2024** |
| Weighted average number of outstanding ordinary shares in issue | 857038725 | 856030704 |
| Net income attributable to the Company (US$'000) | 454954 | 25801 |
| Basic earnings per share attributable to the Company (US$ per share) | 0.53 | 0.03 |

---

**(ii) Diluted earnings per share**

Diluted earnings per share is calculated by dividing net income attributable to the Company by the weighted average number of outstanding ordinary shares in issue and dilutive ordinary share equivalents outstanding during the period. Dilutive ordinary share equivalents include shares issuable upon the exercise or settlement of share options and LTIP awards issued by the Company using the treasury stock method.

---

| | | |
|:---|:---|:---|
|  | **Six Months Ended June 30,** | **Six Months Ended June 30,** |
|  | **2025** | **2024** |
| Weighted average number of outstanding ordinary shares in issue | 857038725 | 856030704 |
| Effect of share options and LTIP awards | 15525788 | 16503762 |
| Weighted average number of outstanding ordinary shares in issue and dilutive ordinary share equivalents outstanding | 872564513 | 872534466 |
| Net income attributable to the Company (US$'000) | 454954 | 25801 |
| Diluted earnings per share attributable to the Company (US$ per share) | 0.52 | 0.03 |

---

**20. Segment Reporting**

The Group's operating segments are as follows:

&nbsp;&nbsp;&nbsp;&nbsp;(i) Oncology/Immunology: focuses on discovering, developing, and commercializing targeted therapies and immunotherapies for the treatment of cancer and immunological diseases. Oncology/Immunology is further segregated into two core business areas:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) R&D: comprises research and development activities covering drug discovery, development, manufacturing and regulatory functions, out-licensing of in-house developed drugs, as well as administrative activities to support research and development operations; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Marketed Products: comprises the invoiced sales, marketing, manufacture and distribution of drugs developed from research and development activities including out-licensed marketed products.

&nbsp;&nbsp;&nbsp;&nbsp;(ii) Other Ventures: comprises other commercial businesses which include the sales, marketing, manufacture and distribution of other prescription drugs and healthcare products.

In general, revenue, cost of revenue and operating expenses are directly attributable, or are allocated, to each segment. The Company allocates costs and expenses that are not directly attributable to a specific segment mainly on the basis of headcount or usage, depending on the nature of the relevant costs and expenses. The Company does not allocate assets to its segments as the chief operating decision maker does not evaluate the performance of segments using asset information.

The performance of the reportable segments is assessed based on segment net income attributable to the Company.

**(i)** **Segment information:**

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **Six Months Ended June 30, 2025** | **Six Months Ended June 30, 2025** | **Six Months Ended June 30, 2025** | **Six Months Ended June 30, 2025** | **Six Months Ended June 30, 2025** | **Six Months Ended June 30, 2025** |
|  | **Oncology/Immunology**  | **Oncology/Immunology**  | **Oncology/Immunology**  | | | |
|  | <br>**R&D** | **Marketed**<br>**Products**  | <br>**Subtotal** | <br>**Other**<br>**Ventures** | <br>**Unallocated** | <br>**Total** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Revenue from external customers | 44408 | 99039 | 143447 | 134230 |  | 277677 |
| Cost of revenue |  | (38223) | (38223) | (129354) |  | (167577) |
| Research and development expenses | (71990) |  | (71990) |  |  | (71990) |
| Selling expenses |  | (11828) | (11828) | (2045) |  | (13873) |
| Administrative expenses | (14599) | (1564) | (16163) | (2222) | (9366) | (27751) |
| Gain on divestment of an equity investee |  |  |  | 477456 |  | 477456 |
| Interest income | 509 |  | 509 | 57 | 19023 | 19589 |
| Interest expense | (1033) |  | (1033) | (257) | (175) | (1465) |
| Equity in earnings of an equity investee, net of tax |  |  |  | 23125 |  | 23125 |
| Income tax expense | (394) | (67) | (461) | (61614) | (1087) | (63162) |
| Other segment items | (2612) | (74) | (2686) | 928 | 4683 | 2925 |
| Net (loss)/income attributable to the Company | (45711) | 47283 | 1572 | 440304 | 13078 | 454954 |
| Depreciation/ amortization | (5602) | (422) | (6024) | (51) | (43) | (6118) |
| Additions to non-current assets (other than financial instruments and deferred tax assets) | 5649 | 10000 | 15649 | 150 |  | 15799 |

---

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **Six Months Ended June 30, 2024** | **Six Months Ended June 30, 2024** | **Six Months Ended June 30, 2024** | **Six Months Ended June 30, 2024** | **Six Months Ended June 30, 2024** | **Six Months Ended June 30, 2024** |
|  | **Oncology/Immunology**  | **Oncology/Immunology**  | **Oncology/Immunology**  | | | |
|  | <br>**R&D** | **Marketed**<br>**Products** | <br>**Subtotal** | <br>**Other**<br>**Ventures** | <br>**Unallocated** | <br>**Total** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Revenue from external customers | 40841 | 127796 | 168637 | 137044 |  | 305681 |
| Cost of revenue |  | (48458) | (48458) | (131677) |  | (180135) |
| Research and development expenses | (95256) |  | (95256) |  |  | (95256) |
| Selling expenses |  | (24817) | (24817) | (2534) |  | (27351) |
| Administrative expenses | (16395) | (341) | (16736) | (2346) | (11378) | (30460) |
| Interest income | 418 |  | 418 | 116 | 20040 | 20574 |
| Interest expense | (914) |  | (914) | (362) | (200) | (1476) |
| Equity in earnings of an equity investee, net of tax |  |  |  | 33807 |  | 33807 |
| Income tax expense | (579) | (530) | (1109) | (97) | (1680) | (2886) |
| Other segment items | 4048 | (455) | 3593 | 198 | (488) | 3303 |
| Net (loss)/income attributable to the Company | (67837) | 53195 | (14642) | 34149 | 6294 | 25801 |
| Depreciation/ amortization | (6076) |  | (6076) | (130) | (46) | (6252) |
| Additions to non-current assets (other than financial instruments and deferred tax assets) | 3763 |  | 3763 | 1929 | 1234 | 6926 |

---

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **June 30, 2025** | **June 30, 2025** | **June 30, 2025** | **June 30, 2025** | **June 30, 2025** | **June 30, 2025** |
|  | **Oncology/Immunology** | **Oncology/Immunology** | **Oncology/Immunology** | | | |
|  | <br>**R&D** | **Marketed**<br>**Products** | <br>**Subtotal** | <br>**Other**<br>**Ventures** | <br>**Unallocated** | <br>**Total** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Total assets | 209654 | 104056 | 313710 | 156150 | 1306080 | 1775940 |
| Property, plant and equipment | 94080 |  | 94080 | 415 | 78 | 94573 |
| Right-of-use assets | 1730 |  | 1730 | 1317 | 832 | 3879 |
| Leasehold land | 10883 |  | 10883 |  |  | 10883 |
| Intangible asset (note) |  | 9647 | 9647 |  |  | 9647 |
| Goodwill |  |  |  | 3064 |  | 3064 |
| Investment in an equity investee |  |  |  | 3645 |  | 3645 |
| Investment in equity security | 5000 |  | 5000 |  |  | 5000 |

---

Note: During the six months ended June 30, 2025, Tazemetostat was granted approval by the National Medical Products Administration of China for the treatment of adult patients with relapsed or refractory follicular lymphoma with EZH2 mutation, triggering a US$10 million milestone payment, and a corresponding intangible asset was recognized.

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **December 31, 2024** | **December 31, 2024** | **December 31, 2024** | **December 31, 2024** | **December 31, 2024** | **December 31, 2024** |
|  | **Oncology/Immunology** | **Oncology/Immunology** | **Oncology/Immunology** | | | |
|  | <br>**R&D** | **Marketed**<br>**Products** | <br>**Subtotal** | <br>**Other**<br>**Ventures** | <br>**Unallocated** | <br>**Total** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Total assets | 225661 | 88502 | 314163 | 194604 | 765429 | 1274196 |
| Property, plant and equipment | 91929 |  | 91929 | 448 | 121 | 92498 |
| Right-of-use assets | 1845 |  | 1845 | 1615 | 1037 | 4497 |
| Leasehold land | 10706 |  | 10706 |  |  | 10706 |
| Goodwill |  |  |  | 2990 |  | 2990 |
| Investment in an equity investee |  |  |  | 77765 |  | 77765 |
| Investment in equity security | 5000 |  | 5000 |  |  | 5000 |

---

Unallocated expenses mainly represent corporate expenses which include corporate administrative costs, corporate employee benefit expenses and the relevant share-based compensation expenses, net of interest income. Unallocated assets mainly comprise cash and cash equivalents and short-term investments.

**(ii)** **Geographic information:**

---

| | | |
|:---|:---|:---|
|  | **Six Months Ended June 30,** | **Six Months Ended June 30,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Revenue from external customers: |  |  |
| &nbsp;&nbsp;PRC | 205120 | 229069 |
| &nbsp;&nbsp;US and Others | 72557 | 76612 |
|  | 277677 | 305681 |

---

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **June 30, 2025** | **June 30, 2025** | **June 30, 2025** | **December 31, 2024** | **December 31, 2024** | **December 31, 2024** |
|  | **PRC** | **US and Others** | **Total** | **PRC** | **US and Others** | **Total** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Total assets | 1716982 | 58958 | 1775940 | 1212722 | 61474 | 1274196 |
| Property, plant and equipment | 94030 | 543 | 94573 | 91849 | 649 | 92498 |
| Right-of-use assets | 3252 | 627 | 3879 | 4086 | 411 | 4497 |
| Leasehold land | 10883 |  | 10883 | 10706 |  | 10706 |
| Intangible asset | 9647 |  | 9647 |  |  |  |
| Goodwill | 3064 |  | 3064 | 2990 |  | 2990 |
| Investment in an equity investee | 3645 |  | 3645 | 77765 |  | 77765 |
| Investment in equity security | 5000 |  | 5000 | 5000 |  | 5000 |

---

**(iii)** **Other information:**

A summary of customers which accounted for over 10% of the Group's revenue for the six months ended June 30, 2025 and 2024 is as follows:

---

| | | |
|:---|:---|:---|
|  | **Six Months Ended June 30,** | **Six Months Ended June 30,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Customer A | 72557 | 76612 |
| Customer B | 32513 | 45396 |

---

Customer A and B are included in Oncology/Immunology.

**21. Note to Condensed Consolidated Statements of Cash Flows**

Reconciliation of net income for the period to net cash used in operating activities:

---

| | | |
|:---|:---|:---|
|  | **Six Months Ended June 30,**  | **Six Months Ended June 30,**  |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Net income | 455555 | 26165 |
| Adjustments to reconcile net income to net cash used in operating activities |  |  |
| &nbsp;&nbsp;Depreciation and amortization | 6118 | 6252 |
| &nbsp;&nbsp;Share-based compensation expense—share options | 1552 | 1432 |
| &nbsp;&nbsp;Share-based compensation expense—LTIP | 7691 | 9880 |
| &nbsp;&nbsp;Equity in earnings of an equity investee, net of tax | (23125) | (33807) |
| &nbsp;&nbsp;Gain from divestment of an equity investee | (477456) |  |
| &nbsp;&nbsp;Dividends received from an equity investee | 6987 |  |
| &nbsp;&nbsp;Other adjustments | 2606 | 709 |
| Changes in operating assets and liabilities |  |  |
| &nbsp;&nbsp;Accounts receivable | 8596 | (39879) |
| &nbsp;&nbsp;Other receivables, prepayments and deposits | (4943) | (393) |
| &nbsp;&nbsp;Amounts due from related parties | 204 | 228 |
| &nbsp;&nbsp;Inventories | 2095 | 3636 |
| &nbsp;&nbsp;Accounts payable | 1204 | 7071 |
| &nbsp;&nbsp;Other payables, accruals and advance receipts | (37433) | (4410) |
| &nbsp;&nbsp;Deferred revenue | (22718) | (16363) |
| &nbsp;&nbsp;Others | 173 | (353) |
| Total changes in operating assets and liabilities | (52822) | (50463) |
| Net cash used in operating activities | (72894) | (39832) |

---

**22. Litigation**

From time to time, the Group may become involved in litigation relating to claims arising from the ordinary course of business. The Group believes that there are currently no claims or actions pending against the Group, the ultimate disposition of which could have a material adverse effect on the Group's financial position, results of operations or cash flows. However, litigation is subject to inherent uncertainties and the Group's view of these matters may change in the future. When an unfavorable outcome occurs, there exists the possibility of a material adverse impact on the Group's financial position, results of operations or cash flows for the periods in which the unfavorable outcome occurs, and potentially in future periods.

On May 17, 2019, Luye Pharma Hong Kong Ltd. ("Luye") issued a notice to the Group purporting to terminate a distribution agreement that granted the Group exclusive commercial rights to Seroquel in the PRC for failure to meet a pre-specified target. The Group disagrees with this assertion and believes that Luye have no basis for termination. As a result, the Group commenced legal proceedings in 2019 in order to seek damages. On October 21, 2021 (and a decision on costs and interest in December 2021), the Group was awarded an amount of US$35.4 million (RMB253.2 million) with interest of 5.5% per annum from the date of the award until payment and recovery of costs of approximately US$2.2 million (collectively the "Award"). On June 27, 2022, Luye provided the Group a bank guarantee of up to RMB286.0 million (updated to RMB325.0 million on June 27, 2025) to cover the Award amounts, pending the outcome of an application by Luye to the High Court of Hong Kong to set aside the Award and subsequent appeals. On July 26, 2022, Luye's application to set aside the Award was dismissed by the High Court with costs awarded in favor of the Group. On October 7, 2022, Luye filed a Notice of Appeal to the Court of Appeal regarding the dismissal and the notice was accepted on November 8, 2022. On June 6, 2023, an appeal hearing filed by Luye was heard by the Court of Appeal and judgment is awaited. The legal proceedings are ongoing and as no Award amounts have been received as at the issuance date of these condensed consolidated financial statements, no Award amounts have been recognized and no adjustment has been made to Seroquel-related balances as at June 30, 2025. Such Seroquel-related balances include accounts receivable, accounts payable and other payables of US$1.1 million, US$0.9 million and US$1.1 million respectively.

**23. Subsequent Events**

The Group evaluated subsequent events through August 7, 2025, which is the date when the interim unaudited condensed consolidated financial statements were issued.

On July 25, 2025, Inmagene Biopharmaceuticals ("Inmagene") announced it had completed a merger with Ikena Oncology, Inc. and the merged company is listed on the NASDAQ as ImageneBio, Inc. ("ImageneBio"). ImageneBio will be primarily focused on the development of IMG-007, a monoclonal antibody targeting OX-40 licensed from the Group. Inmagene's remaining assets including IMG-004, a non-covalent, reversable small molecule inhibitor targeting Bruton Tyrosine Kinase licensed from the Group, were spun out to Miragene Inc. ("Miragene"), a new private company. As a result of the merger, the Group's investment in equity security (140,636,592 Inmagene ordinary shares) was exchanged for 429,082 shares in ImageneBio and 7,960,562 shares in Miragene. The Group will have a director on both ImageneBio's and Miragene's board of directors.

## Exhibit 99.2

**Exhibit 99.2**

**Dividends**

No dividend has been declared or paid by the Company since its incorporation.

**Reconciliation between US GAAP and International Financial Reporting Standards**

These interim unaudited condensed consolidated financial statements are prepared in accordance with US GAAP, which differ in certain respects from International Financial Reporting Standards ("IFRS"). The effects of material differences prepared under US GAAP and IFRS are as follows:

&nbsp;&nbsp;&nbsp;&nbsp;**(i)** **Reconciliation of condensed consolidated statements of operations** 

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
|  | **Six Months Ended June 30, 2025** | **Six Months Ended June 30, 2025** | **Six Months Ended June 30, 2025** | **Six Months Ended June 30, 2025** | **Six Months Ended June 30, 2025** |
|  | | **IFRS adjustments** | **IFRS adjustments** | **IFRS adjustments** | |
|  | <br>**Amounts as**<br>**reported under** <br>**US GAAP** | <br>**Lease**<br>**amortization** <br>**(note (a))** | **Tax effects of** <br>**intercompany** <br>**unrealized** <br>**profit**<br>**(note (b))** | <br>**Capitalization**<br>**of rights**<br>**(note (c))** | <br>**Amounts** <br>**under IFRS** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Cost of goods—third parties | (147601) | 7 |  |  | (147594) |
| Research and development expenses | (71990) | 40 |  | (16109) | (88059) |
| Selling expenses | (13873) | 11 |  |  | (13862) |
| Administrative expenses | (27751) | 26 |  |  | (27725) |
| **Total operating expenses** | **(281191)** | **84** | **—** | **(16109)** | **(297216)** |
| Gain on divestment of an equity investee | 477456 | 18 | (151) |  | 477323 |
| Other income, net | 21650 | (104) |  |  | 21546 |
| **Income/(loss) before income taxes and equity in earnings of an equity investee** | **495592** | **(2)** | **(151)** | **(16109)** | **479330** |
| Equity in earnings of an equity investee, net of tax | 23125 | 6 | (91) |  | 23040 |
| **Net income** | **455555** | **4** | **(242)** | **(16109)** | **439208** |
| Less: Net income attributable to non-controlling interests | (601) | 3 |  | 25 | (573) |
| **Net income attributable to the Company** | **454954** | **7** | **(242)** | **(16084)** | **438635** |

---

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **Six Months Ended June 30, 2024** | **Six Months Ended June 30, 2024** | **Six Months Ended June 30, 2024** | **Six Months Ended June 30, 2024** |
|  | | **IFRS adjustment** | **IFRS adjustment** | |
|  | <br>**Amounts as** <br>**reported under** <br>**US GAAP** | <br>**Lease**<br>**amortization**<br>**(note (a))** | **Tax effects of**<br>**intercompany**<br>**unrealized profit**<br>**(note (b))** | <br>**Amounts** <br>**under IFRS** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Cost of goods—third parties | (151681) | 31 |  | (151650) |
| Research and development expenses | (95256) | 49 |  | (95207) |
| Selling expenses | (27351) | 18 |  | (27333) |
| Administrative expenses | (30460) | 40 |  | (30420) |
| **Total operating expenses** | **(333202)** | **138** | **—** | **(333064)** |
| Other income, net | 22765 | (91) |  | 22674 |
| **Income/(loss) before income taxes and equity in earnings of an equity investee** | **(4756)** | **47** |  | **(4709)** |
| Equity in earnings of an equity investee, net of tax | 33807 | 6 | (215) | 33598 |
| **Net income** | **26165** | **53** | **(215)** | **26003** |
| Less: Net income attributable to non-controlling interests | (364) | (7) |  | (371) |
| **Net income attributable to the Company** | **25801** | **46** | **(215)** | **25632** |

---

------

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

&nbsp;&nbsp;&nbsp;&nbsp;**(ii)** **Reconciliation of condensed consolidated balance sheets** 

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **June 30, 2025** | **June 30, 2025** | **June 30, 2025** | **June 30, 2025** | **June 30, 2025** | **June 30, 2025** |
|  | | **IFRS adjustments** | **IFRS adjustments** | **IFRS adjustments** | **IFRS adjustments** | |
|  | <br>**Amounts as** <br>**reported under** <br>**US GAAP** | <br>**Lease** <br>**amortization** <br>**(note (a))** | **Tax effects of**<br>**intercompany**<br>**unrealized profit** <br>**(note (b))** | <br>**Issuance costs** <br>**(note (d))** | <br>**LTIP classification** <br>**(note (e))** | <br>**Amounts** <br>**under IFRS** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Investment in an equity investee | 3645 | (1) | 8 |  |  | 3652 |
| Other non-current assets | 40620 | (74) |  |  |  | 40546 |
| **Total assets** | **1775940** | **(75)** | **8** | **—** | **—** | **1775873** |
| Other payables, accruals and advance receipts | 221061 |  |  |  | (71) | 220990 |
| **Total current liabilities** | **342349** | **—** | **—** | **—** | **(71)** | **342278** |
| **Total liabilities** | **534017** | **—** | **—** | **—** | **(71)** | **533946** |
| Additional paid-in capital | 1527662 |  |  | (697) | 71 | 1527036 |
| Accumulated losses | (380319) | (75) | 8 | 697 |  | (379689) |
| Accumulated other comprehensive loss | (5490) | 11 |  |  |  | (5479) |
| **Total Company's shareholders' equity** | **1229064** | **(64)** | **8** | **—** | **71** | **1229079** |
| Non-controlling interests | 12859 | (11) |  |  |  | 12848 |
| **Total shareholders' equity** | **1241923** | **(75)** | **8** | **—** | **71** | **1241927** |

---

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
|  | **December 31, 2024** | **December 31, 2024** | **December 31, 2024** | **December 31, 2024** | **December 31, 2024** | **December 31, 2024** | **December 31, 2024** |
|  | | **IFRS adjustments** | **IFRS adjustments** | **IFRS adjustments** | **IFRS adjustments** | **IFRS adjustments** | |
|  | <br>**Amounts as** <br>**reported under** <br>**US GAAP** | <br>**Lease** <br>**amortization** <br>**(note (a))** | **Tax effects of**<br>**intercompany** <br>**unrealized** <br>**profit** <br>**(note (b))** | <br>**Capitalization**<br>**of rights**<br>**(note (c))** | <br>**Issuance** <br>**costs** <br>**(note (d))** | <br>**LTIP** <br>**classification** <br>**(note (e))** | <br>**Amounts** <br>**under IFRS** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Investment in an equity investee | 77765 | (22) | 246 |  |  |  | 77989 |
| Other non-current assets | 32378 | (52) |  | 14815 |  |  | 47141 |
| **Total assets** | **1274196** | **(74)** | **246** | **14815** | **—** | **—** | **1289183** |
| Other payables, accruals and advance receipts | 256124 |  |  |  |  | (493) | 255631 |
| **Total current liabilities** | **376562** | **—** | **—** | **—** | **—** | **(493)** | **376069** |
| **Total liabilities** | **502343** | **—** | **—** | **—** | **—** | **(493)** | **501850** |
| Additional paid-in capital | 1517526 |  |  |  | (697) | 493 | 1517322 |
| Accumulated losses | (833172) | (82) | 250 | 16084 | 697 |  | (816223) |
| Accumulated other comprehensive loss | (11585) | 16 | (4) | (1294) |  |  | (12867) |
| **Total Company's shareholders' equity** | **759929** | **(66)** | **246** | **14790** | **—** | **493** | **775392** |
| Non-controlling interests | 11924 | (8) |  | 25 |  |  | 11941 |
| **Total shareholders' equity** | **771853** | **(74)** | **246** | **14815** | **—** | **493** | **787333** |

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Notes:

&nbsp;&nbsp;&nbsp;&nbsp;(a) Lease amortization

Under US GAAP, for operating leases, the amortization of right-of-use assets and the interest expense element of lease liabilities are recorded together as lease expenses, which results in a straight-line recognition effect in the condensed consolidated statements of operations.

Under IFRS, all leases are accounted for like finance leases where right-of-use assets are generally depreciated on a straight-line basis while lease liabilities are measured under the effective interest method, which results in higher expenses at the beginning of the lease term and lower expenses near the end of the lease term.

&nbsp;&nbsp;&nbsp;&nbsp;(b) Tax effects of intercompany unrealized profit

Under US GAAP, deferred taxes for unrealized profit resulting from intercompany sales of inventory is not recognized.

Under IFRS, deferred taxes for unrealized profit resulting from an intercompany sale of inventory is recognized at the buyer's tax rate.

&nbsp;&nbsp;&nbsp;&nbsp;(c) Capitalization of development and commercial rights

Under US GAAP, the acquired development and commercial rights do not meet the capitalization criteria as further development is needed as of the acquisition date and there is no alternative future use. Such rights are considered as IPR&D and were expensed to research and development expense.

Under IFRS, the acquired development and commercial rights were capitalized to intangible assets. The recognition criterion is always assumed to be met as the price already reflects the probability that future economic benefits will flow to the Group. For the six months ended June 30, 2025, the intangible asset was impaired after completing an impairment assessment.

&nbsp;&nbsp;&nbsp;&nbsp;(d) Issuance costs

Under US GAAP and IFRS, there are differences in the criteria for capitalization of issuance costs incurred in the offering of equity securities.

&nbsp;&nbsp;&nbsp;&nbsp;(e) LTIP classification

Under US GAAP, LTIP awards with performance conditions are classified as liability-settled awards prior to the determination date as they settle in a variable number of shares based on a determinable monetary amount, which is determined upon the actual achievement of performance targets. After the determination date, the LTIP awards are reclassified as equity-settled awards.

Under IFRS, LTIP awards are classified as equity-settled awards, both prior to and after the determination date, as they are ultimately settled in ordinary shares or the equivalent ADS of the Company instead of cash.

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