# EDGAR Filing Document

**Accession Number:** 0001953530
**File Stem:** 0001193125-25-135923
**Filing Date:** 2025-6
**Character Count:** 35819
**Document Hash:** ce0d4f3e4ab04dfb87062f54db719bbc
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-25-135923.hdr.sgml**: 20250605

**ACCESSION NUMBER**: 0001193125-25-135923

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 5

**FILED AS OF DATE**: 20250605

**DATE AS OF CHANGE**: 20250605

**EFFECTIVENESS DATE**: 20250605

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Oculis Holding AG
- **CENTRAL INDEX KEY:** 0001953530
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** V8
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-287806
- **FILM NUMBER:** 251027681

**BUSINESS ADDRESS:**
- **STREET 1:** BAHNHOFSTRASSE 7
- **CITY:** ZUG
- **STATE:** V8
- **ZIP:** 6300
- **BUSINESS PHONE:** 617-937-2423

**MAIL ADDRESS:**
- **STREET 1:** BAHNHOFSTRASSE 7
- **CITY:** ZUG
- **STATE:** V8
- **ZIP:** 6300

**As filed with the Securities and Exchange Commission on June 5, 2025**

**Registration No. 333-** 

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**FORM S-8**

**REGISTRATION STATEMENT**

***UNDER***

***THE SECURITIES ACT OF 1933***

## OCULIS HOLDING AG
**(Exact name of Registrant as Specified in Its Charter)**

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| | | |
|:---|:---|:---|
| **Switzerland** | **2834** | **Not Applicable** |
| **(Jurisdiction of Incorporation or**<br> **Organization)** | **(Primary Standard Industrial Classification**<br> **Code Number)** | **(I.R.S. Employer**<br> **Identification No.)** |

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**Bahnhofstrasse 20**

**CH-6300**

**Zug, Switzerland** 

**Tel.: +41-41-711-3960**

**(Address, including zip code, and telephone number, including area code, of Registrant's principal executive offices)**

**Stock Option and Incentive Plan Regulation 2023**

**(Full title of the plan)**

**Oculis US Inc.**

**One Gateway Center** 

**300 Washington Street, Suite 405** 

**Newton, MA 02458** 

**Tel.: +1 (617) 928 5886** 

**(Name, address, including zip code, and telephone number, including area code, of agent for service)**

***Copies to:***

**Divakar Gupta**

**Katie Kazem** 

**Cooley LLP**

**11951 Freedom Dr**

**Suite 1400**

**Reston, VA 20194** 

**Tel: +1 (703) 456 8000**

**Fax: +1 (703) 450 8100**

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

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| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☐ | Accelerated filer | ☐ |
| Non-accelerated filer | ☒ | Smaller reporting company | ☐ |
|  |  | Emerging growth company | ☒ |

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If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

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**EXPLANATORY NOTE** 

Oculis Holding AG, a stock corporation (*Aktiengesellschaft*) incorporated and existing under the laws of Switzerland (the "<u>Company</u>") is filing this Registration Statement with the Securities and Exchange Commission (the "<u>Commission</u>") to register an additional 4,644,456 ordinary shares issuable under the Company's Stock Option and Incentive Plan Regulation 2023.

As used in this Registration Statement, unless the context otherwise requires, references to "we," "us" and "our" refer to Oculis Holding AG.

**PART I**

**INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS**

The documents containing the information specified in Part I of this Registration Statement will be delivered in accordance with Form S-8 and Rule 428(d) under the Securities Act of 1933, as amended (the "<u>Securities Act</u>"). These documents are not required to be, and are not, filed with Commission either as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424 of the Securities Act. The documents containing the information specified in Part I will be sent or given to participants as specified by Rule 428(b)(1) under the Securities Act. These documents and the documents incorporated by reference in this Registration Statement pursuant to Item 3 of Part II of this Registration Statement, taken together, constitute a prospectus that meets the requirements of Section 10(a) of the Securities Act.

Our ordinary shares are listed on The Nasdaq Stock Market LLC under the ticker symbol "OCS" and on The Nasdaq Iceland Main Market under the ticker symbol "OCS". Our warrants are listed on The Nasdaq Stock Market LLC under the ticker symbol "OCSAW".

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| | |
|:---|:---|
| **ITEM 1.** | **PLAN INFORMATION**  |

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Not required to be filed with this Registration Statement.

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| | |
|:---|:---|
| **ITEM 2.** | **REGISTRANT INFORMATION AND EMPLOYEE PLAN ANNUAL INFORMATION**  |

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Not required to be filed with this Registration Statement.

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**PART II**

**INFORMATION REQUIRED IN THE REGISTRATION STATEMENT**

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| | |
|:---|:---|
| **ITEM 3.** | **INCORPORATION OF DOCUMENTS BY REFERENCE**  |

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The following document(s) filed with the Commission by the Company, pursuant to the Securities Act and the Securities Exchange Act of 1934, as amended (the "<u>Exchan</u>g<u>e Act</u>"), are incorporated herein by reference:

(1) The Company's Annual Report on Form 20-F for the year ended December 31, 2024, filed with the Commission on [March 11, 2025](http://www.sec.gov/Archives/edgar/data/1953530/000095017025037224/ocs-20241231.htm);

(2) The Company's Reports on Form 6-K, filed with the Commission on [March 11, 2025](http://www.sec.gov/Archives/edgar/data/1953530/000095017025037201/ocs_6-k_erifrssfs_2024.htm), [April 14, 2025](http://www.sec.gov/Archives/edgar/data/1953530/000095017025054236/2025_rd_day.htm) (excluding Exhibit 99.2), [May 8, 2025](http://www.sec.gov/Archives/edgar/data/1953530/000095017025066993/q1_2025_6-k_fs_mda_pr.htm) (excluding Exhibit 99.3), [May 9, 2025](http://www.sec.gov/Archives/edgar/data/1953530/000095017025068021/6-k__agm_materials_2024.htm) and [June 5, 2025](http://www.sec.gov/Archives/edgar/data/1953530/000095017025082305/6-k_agm_results_2025.htm) (excluding Exhibit 99.1); and

(3) The description of the Company's Ordinary Shares contained in the Registrant's Registration Statement on Form 8-A filed on [February 28, 2023](http://www.sec.gov/Archives/edgar/data/1953530/000119312523054545/d469614d8a12b.htm), including any amendment or report filed for the purpose of updating such description.

In addition to the foregoing, all documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, and all reports on Form 6-K, or portions thereof, subsequently filed by the Registrant which state that they are incorporated by reference herein, prior to the filing of a post-effective amendment which indicates that all securities offered hereunder have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be part hereof from the date of filing of such documents and reports.

Any document or any statement contained in a document or report incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a document or a statement contained in any subsequently filed document or report that is also incorporated or deemed to be incorporated by reference herein modifies or supersedes such document or statement. Any statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement. Subject to the foregoing, all information appearing in the Registration Statement is qualified in its entirety by the information appearing in the documents incorporated by reference.

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| | |
|:---|:---|
| **ITEM 4.** | **DESCRIPTION OF SECURITIES**  |

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Not applicable.

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| | |
|:---|:---|
| **ITEM 5.** | **INTERESTS OF NAMED EXPERTS AND COUNSEL**  |

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None.

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| | |
|:---|:---|
| **ITEM 6.** | **INDEMNIFICATION OF DIRECTORS AND OFFICERS**  |

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Under Swiss corporate law, an indemnification by the corporation of a director or member of the executive committee in relation to potential personal liability is not effective to the extent the director or member of the executive committee intentionally or negligently violated his or her corporate duties towards the corporation. Furthermore, the general meeting of shareholders may discharge (release) the directors and members of the executive committee from liability for their conduct to the extent the shareholders have knowledge of the relevant facts of a potential claim. Such discharge is effective only with respect to claims of the company and of those shareholders who approved the discharge or who have since acquired their shares in full knowledge of the discharge. Most violations of corporate law are regarded as violations of duties towards the corporation rather than towards the shareholders. In addition, indemnification of other controlling persons is not permitted under Swiss corporate law, including shareholders of the corporation.

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Our Articles of Association provide for indemnification of the existing and former members of the board of directors or the executive committee against liabilities arising in connection with the performance of their duties in such capacity. In addition, under general principles of Swiss employment law, an employer may be required to indemnify an employee against losses and expenses incurred by such employee in the proper execution of his or her duties under the employment agreement with the employer.

We have entered into indemnification agreements with each of the members of our board of directors and executive officers, the form of which has been filed as an exhibit to our annual report on Form 20-F filed with the Securities and Exchange Commission.

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| | |
|:---|:---|
| **ITEM 7.** | **EXEMPTION FROM REGISTRATION CLAIMED**  |

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Not applicable.

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| | |
|:---|:---|
| **ITEM 8.** | **EXHIBITS**  |

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| | |
|:---|:---|
| &nbsp;&nbsp;&nbsp;&nbsp;4.1 | [Amended and Restated Articles of Association of Oculis Holding AG (incorporated by reference to Exhibit 99.2 to our Report on Form 6-K filed on June 5, 2025).](http://www.sec.gov/Archives/edgar/data/1953530/000095017025037224/ocs-ex1_1.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;5.1\* | [Opinion of Vischer AG, Swiss counsel to Oculis Holding AG, as to the validity of the Ordinary Shares being registered.](d933644dex51.htm) |
| 10.1 | [Stock Option and Incentive Plan Regulation 2023 of Oculis Holding AG (incorporated by reference to Exhibit 4.7 to our Report on Form 20-F filed on March 11, 2025).](http://www.sec.gov/Archives/edgar/data/1953530/000119312523003678/d389734dex1013.htm) |
| 23.1\* | [Consent of PricewaterhouseCoopers, SA., independent registered accounting firm for Oculis Holding AG.](d933644dex231.htm) |
| 23.2\* | [Consent of Vischer AG (included as part of Exhibit 5.1).](d933644dex51.htm) |
| 24.1\* | [Power of Attorney (included on the signature page hereto).](d933644ds8.htm#sig) |
| 107\* | [Filing Fee Table.](d933644dexfilingfees.htm) |

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\* Filed herewith.

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| | |
|:---|:---|
| **ITEM 9.** | **UNDERTAKINGS**  |

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(a) The undersigned Registrant hereby undertakes:

(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) To include any prospectus required by Section 10(a)(3) of the Securities Act;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) To reflect in the prospectus any facts or events arising after the effective date of this Registration
Statement (or the most recent post- effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this Registration Statement. Notwithstanding the foregoing, any increase or
decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of
prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than 20% change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee"
table in the effective registration statement;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) To include any material information with respect to the plan of distribution not previously disclosed in this
Registration Statement or any material change to such information in this Registration Statement;

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*provided*, *however*, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or 15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.

(2) That, for the purpose of determining any liability under the Securities Act each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

(3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

(b) The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial *bona fide* offering thereof.

(c) Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.

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**SIGNATURES** 

Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in Switzerland, on June 5, 2025.

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| | |
|:---|:---|
| **OCULIS HOLDING AG** | **OCULIS HOLDING AG** |
| By: | /s/ Riad Sherif |
| Name: Riad Sherif | Name: Riad Sherif |
| Title: Chief Executive Officer | Title: Chief Executive Officer |

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**POWER OF ATTORNEY** 

Each of the undersigned individuals hereby severally constitutes and appoints each of Riad Sherif and Sylvia Cheung as the attorneys-in-fact for the undersigned, in any and all capacities, with full power of substitution, to sign on such person's behalf, individually and in each capacity stated below, any and all amendments to this registration statement, and any subsequent registration statement filed by the Registrant pursuant to Rule 462(b) of the Securities Act, and to file or cause to be filed the same, with all exhibits thereto, and other documents in connection therewith, with the SEC, granting unto said attorneys-in-fact, and each of them, full power and authority to do and perform each and every act and thing requisite or necessary to be done in connection therewith, as fully to all intents and purposes as such person might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact, and each of them, or his or her substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following person in the capacities indicated and on the date indicated below.

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| | | |
|:---|:---|:---|
| **Signature** | **Title** | **Date** |
| /s/ Riad Sherif<br> Riad Sherif | Chief Executive Officer<br> (Principal Executive Officer) | June 5, 2025 |
| /s/ Sylvia Cheung<br> Sylvia Cheung | Chief Financial Officer<br> (Principal Financial and Accounting Officer) | June 5, 2025 |
| /s/ Anthony Rosenberg<br> Anthony Rosenberg | Executive Chairman of the Board | June 5, 2025 |
| /s/ Arshad M. Khanani, M.D.<br> Arshad M. Khanani, M.D. | Director | June 5, 2025 |
| /s/ Christina Ackermann<br> Christina Ackermann | Director | June 5, 2025 |
| /s/ Geraldine O'Keeffe<br> Geraldine O'Keeffe | Director | June 5, 2025 |
| /s/ Lionel Carnot<br> Lionel Carnot | Director | June 5, 2025 |
| /s/ Martijn Kleijwegt<br> Martijn Kleijwegt | Director | June 5, 2025 |
| /s/ Robert K. Warner<br> Robert K. Warner | Director | June 5, 2025 |

---

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**SIGNATURE OF AUTHORIZED U.S. REPRESENTATIVE OF THE REGISTRANT** 

Pursuant to the requirements of the Securities Act of 1933, as amended, the undersigned has signed this registration statement, solely in the capacity as the duly authorized representative of the Registrant, in Boston, Massachusetts, on June 5, 2025.

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| | |
|:---|:---|
| **OCULIS US INC** | **OCULIS US INC** |
| By: | /s/ Sylvia Cheung |
| Name: Sylvia Cheung | Name: Sylvia Cheung |

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## Exhibit 5.1

**Exhibit 5.1**![LOGO](g933644g37s00.jpg)

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| | |
|:---|:---|
|  | Registered<br>Oculis Holding AG<br> Bahnhofstrasse 20<br> 6300 Zug<br>June 5, 2025<br>**Oculis Holding AG – Registration Statement on Form S-8** |
| <br> **VISCHER Ltd**<br>**Basel**<br> Aeschenvorstadt 4<br> CH-4010 Basel<br> Switzerland<br> Phone +41 58 211 33 00<br> Fax +41 58 211 33 10<br>**Zurich**<br> Schützengasse 1<br> CH-8021 Zurich<br> Switzerland<br> Phone +41 58 211 34 00<br> Fax +41 58 211 34 10<br>Civil Law Notaries in<br> Basel-City and Baselland | Dear Sir or Madam,<br>We have acted as special Swiss counsel to Oculis Holding AG (the "**Company**"), a company incorporated under the laws of the Switzerland with a share capital of CHF 545,336.74 and 54,533,674 outstanding registered share with a par value of CHF 0.01 each (the "**Registered Shares**"), in connection with the Company's registration statement on Form S-8 as filed with the U.S. Securities and Exchange Commission (the "**Commission**"), as amended or supplemented (the "**Registration Statement**"), to be filed with the United States Securities and Exchange Commission (the "**SEC**") with respect to the registration under the U.S. Securities Act of 1933, as amended (the "**Securities Act**") relating to (i) the registration of up to 12,480,000 registered shares of the Company each with a par value of CHF 0.01 (the "**Plan Shares**") that are issuable under the Company's Stock Option and Incentive Plan Regulation dated January 2023 (the "**2023 Stock Option Plan**").<br>As such counsel, we have been requested to render an opinion as to certain matters of Swiss law.<br>**I. BASIS OF OPINION**<br>This opinion is confined to and given on the basis of the laws of Switzerland in force at the date hereof and as currently applied by Swiss courts. Such laws and the interpretation thereof are subject to change. In the absence of explicit statutory law, we base our opinion on our independent professional judgement.<br>This opinion is also confined to the matters stated herein and is not to be read as extending, by implication or otherwise, to any document referred to in the Documents (other than listed below) any other matter. |

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June 5, 2025 2

For purposes of this opinion we have not conducted any due diligence or similar investigation as to factual circumstances, which are or may be referred to in the Documents, and we express no opinion as to the accuracy of representations and warranties of facts set out in the Documents or the factual background assumed therein.<br>For the purpose of giving this opinion, we have examined originals or copies, certified or otherwise identified to our satisfaction, of<br>a) an electronic copy of the Registration Statement;<br>b) an electronic copy of the 2023 Stock Option Plan enacted by the Company's board of directors on March 2, 2023;<br>c) an electronic copy of the minutes of the Company's board of directors dated March 2, 2023 approving the 2023 Stock Option Plan ("**Board Resolution**");<br>d) an electronic copy of the minutes of the shareholder resolutions passed at the Company's ordinary general meeting held on June 4, 2025, *inter alia*, and resolving on introduction of a conditional share capital in the amount of CHF 124,800 for employee benefit plans allowing for the issuance of a maximum of 12,480,000 Plan Shares (the conditional share capital the "**Conditional Share Capital**", the shareholder resolutions the "**Shareholder Resolution**");<br>e) an uncertified electronic copy of an extract from the Commercial Register of the Canton of Zug (the "**Commercial Register**") dated June 5, 2025 regarding the Company, retrieved online, together with an electronic copy of certified extracts from the Commercial Register dated April 23, 2025 relating to the Company (collectively, the "**Register Extracts**");<br>f) the articles of association (*Statuten*) of the Company dated June 4, 2025, shown on the Register Extracts as being the most recent articles of association filed with the Commercial Register (the "**Articles of Association**");<br>g) the draft articles of association (*Statuten*) of the Company to be filed with the Commercial Register (the "**Revised Articles of Association**").<br>The documents referred to above in the preceding paragraph are referred to together as the "**Documents**".<br>No documents have been reviewed by ourselves in connection with this opinion other than those listed above. Accordingly, our opinion is limited to the above Documents and their legal implications under Swiss law.<br>All terms used in this opinion in uppercase form shall have the meaning ascribed to them in the Registration Statement, unless otherwise defined herein.<br>

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June 5, 2025 3

**II. ASSUMPTIONS** <br>In rendering the opinion below, we have assumed:<br>a) all documents produced to us as originals are authentic and complete, and all documents produced to us as copies (including, without limitation, electronic copies) conform to the original;<br>b) all documents produced to us as originals and the originals of all documents produced to us as copies were duly executed and certified, as applicable, by the individuals purported to have executed or certified, as the case may be, such documents;<br>c) each party to the Documents (other than the Company) is a corporation or other legal entity duly organized and validly existing and in good standing (if applicable) under the laws of the jurisdiction of its incorporation and/or establishment and none of the parties to the Documents (other than the Company) has passed or, until the issuance of the Plan Shares, will have passed a voluntary winding-up resolution; no petition has been, or, until the issuance of the Plan Shares, will be presented or order made by a court for the winding-up, dissolution, bankruptcy or administration of any party (other than the Company); and no receiver, trustee in bankruptcy, administrator or similar officer has been or, until the issuance of the Plan Shares, will have been appointed in relation to any of the parties (other than the Company) or any of their assets or revenues;<br>d) to the extent relevant for purposes of this opinion, any and all information contained in the Documents is and will be true, complete and accurate at all relevant times;<br>e) in relation to the Company, there have been no changes of the Articles of Association, the Revised Articles of Association or their respective registration in the Commercial Register or compared to the Articles of Association or the Revised Articles of Association in the form examined by us;<br>f) the Registration Statement has been filed by the Company;<br>g) the Revised Articles of Association will be duly filed with and registered by the Commercial Register;<br>h) the Shareholder Resolution and the Board Resolutions (i) have been duly resolved in meetings duly convened and otherwise in the manner set forth therein, (ii) have not been amended and (iii) are in full force and effect;<br>i) the 2023 Plan has not been rescinded or amended and is in full force and effect;<br>

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June 5, 2025 4

j) prior to the issuance of any Plan Shares, the board of directors of the Company will have duly authorized the issuance of any options on Plan Shares and, if necessary, will have validly excluded the pre-emptive rights of the existing shareholders for purposes of offering the Plan Shares under the 2023 Stock Option Plan as contemplated in the Registration Statement, and such authorization and exclusion will not have been amended and will be in full force and effect until the issuance of all Plan Shares;<br>k) if applicable, the exercise notice with respect to Plan Shares issued out of the Conditional Share Capital and the will be duly delivered in accordance with Swiss law and the 2023 Stock Option Plan;<br>l) to the extent the Company issues Plan Shares out of the Conditional Share Capital against cash, the performance of the contribution in money shall be made in accordance with the provisions of the 2023 Stock Option Plan and at a banking institution subject to the Swiss Federal Act on Banks and Savings Banks of November 8, 1934, as amended;<br>m) the Company has not entered and will not enter into any transaction which could be construed as repayment of share capital (*Einlagenrückgewähr*) and has not undertaken and will not undertake an acquisition in kind (*Sacheinlage*) without complying with the formal procedure set forth in articles 634 seq. of the Swiss Code of Obligations;<br>n) upon the issuance of Plan Shares out of the conditional share capital of the Company, the Company will register the Plan Shares in the Company's uncertificated securities book (*Wertrechteregister*);<br>o) all authorizations, approvals, consents, licenses, exemptions, other than as required by mandatory Swiss law applicable to the Company or the Articles of Association, and other requirements for the filing of the Registration Statement or for any other activities carried on in view of, or in connection with, the performance of the obligations expressed to be undertaken by the Company in the Registration Statement have been duly obtained or fulfilled in due time and are and will remain in full force and effect, and any related conditions to which the parties thereto are subject have been satisfied; and<br>p) there are no provisions of the laws of any jurisdiction outside Switzerland which would have any implication for the opinion we express and that, insofar as the laws of any jurisdiction outside Switzerland may be relevant, such laws have been or will be complied with.<br>**III. OPINION**<br>Based upon the foregoing and subject to the qualifications set out below, we are of the opinion that:<br>a) The Company is duly incorporated and organized as a stock corporation (*Aktiengesellschaft*) and is validly existing under the laws of Switzerland.<br>

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June 5, 2025 5

b) Upon registration of the Revised Articles of Association, the Company's share capital registered in the Commercial Register of the Canton of Zug amounts to CHF 545,336.74, divided into 54,533,674 Registered Shares. Such Registered Shares have been validly issued, fully paid as to their nominal value and are non-assessable (which term means when used herein that no further contributions have to be made by the holders of the Registered Shares).<br>c) The Plan Shares that may be issued from the Conditional Share Capital, if and when such Plan Shares are issued pursuant to the Articles of Association, the Revised Articles of Association, the 2023 Stock Option Plan and registered with the Commercial Register of the Canton of Zug, and after the nominal amount for such Plan Shares has been paid-in in cash or by way of set-off, and entered into the Company's book of uncertificated securities, will be validly issued, fully paid as to their nominal value and non-assessable (which term means when used herein that no further contributions are required to be made by the holders of the Plan Shares).<br>**IV. QUALIFICATIONS**<br>This opinion is subject to the following qualifications:<br>a) This opinion is limited to matters of Swiss law as in force on the date hereof and as applied and construed by the courts of Switzerland.<br>b) The exercise of voting rights and rights related thereto with respect to any Plan Shares and any Plan Shares is only permissible after registration in the Company's book of uncertificated securities as a shareholder with voting rights in accordance with the provisions of, and subject to the limitations provided in, the Revised Articles of Association.<br>c) The issuance of any Plan Shares out of conditional share capital requires sufficient conditional share capital. We express no opinion as to the future availability of conditional share capital.<br>d) We express no opinion as to whether the Registration Statement is accurate, true, correct, complete or not misleading. In particular, and without limitation to the foregoing, we express no opinion on whether the Registration Statement provides sufficient information for investors to reach an informed assessment of the Company, the Shares and the Plan Shares.<br>e) Notwithstanding or irrespective of the issuance of the Plan Shares and the registration of the Conditional Share Capital reserved for the Plan Shares with the Commercial Register, the underlying shareholder resolutions may still be challenged by a dissenting shareholder of the Company or others in court or otherwise. However, we believe that a challenge of the Shareholder Resolution by a dissenting shareholder of the Company after registration of the Shares with the Commercial Register, even if successful, would not in itself void such Plan Shares.<br>

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June 5, 2025 6

f) The opinion set forth herein is limited to the matters specifically addressed herein, and no other opinion or opinions are expressed or may be implied or inferred. In particular, we express no opinion as to any commercial, calculating, auditing or other non-legal matters. Further, we express in this opinion no opinion as to tax law.<br>We have rendered this opinion as of the date hereof and we assume no obligation to advise you of changes that may thereafter be brought to our attention.<br>In this opinion, Swiss legal concepts are expressed in English terms and not in their original terms. The concepts concerned may not be identical to the concepts described by the same English terms as they exist under the laws of other jurisdictions.<br>We hereby consent to the filing of this opinion as an exhibit to the Registration Statement. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act.<br>This opinion is governed by and shall be construed in accordance with the laws of Switzerland.<br>\* \* \*<br>

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| |
|:---|
| Very truly yours, |
| VISCHER AG |
| /s/ Dr. Matthias Staehelin |
| Dr. Matthias Staehelin |

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## Exhibit 23.1

**Exhibit 23.1** 

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in this Registration Statement on Form S-8 of Oculis Holding AG of our report dated March 11, 2025 relating to the consolidated financial statements, which appears in Oculis Holding AG's Annual Report on Form 20-F for the year ended December 31, 2024.

/s/ PricewaterhouseCoopers SA

Lausanne, Switzerland

June 5, 2025

## Ex-Filing

**Exhibit 107** 

**Calculation of Filing Fee Tables** 

**Form S-8** 

(Form Type)

**Oculis Holding AG** 

(Exact Name of Registrant as Specified in its Charter)

<u>Table 1: Newly Registered Securities</u> 

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| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;&nbsp;Security Type | Security<br> Class<br> Title | Fee<br>Calculation<br>Rule | Amount<br>Registered (1) | Proposed<br>Maximum<br> Offering<br>Price Per<br>Unit (2) | Maximum<br>Aggregate<br>Offering<br> Price | Fee<br> Rate | Amount of<br>Registration<br>Fee |
| &nbsp;&nbsp;&nbsp;Equity | Ordinary Shares, with a nominal value of CHF 0.01 per share | Other | 4644456 | $19.67 | $91101005 | 0.0001531 | $13947.57 |
| &nbsp;&nbsp;&nbsp;Total Offering Amounts | &nbsp;&nbsp;&nbsp;Total Offering Amounts | &nbsp;&nbsp;&nbsp;Total Offering Amounts | &nbsp;&nbsp;&nbsp;Total Offering Amounts |  | $91101005 |  | $13947.57 |
| &nbsp;&nbsp;&nbsp;Total Fee Offsets | &nbsp;&nbsp;&nbsp;Total Fee Offsets | &nbsp;&nbsp;&nbsp;Total Fee Offsets | &nbsp;&nbsp;&nbsp;Total Fee Offsets |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Net Fee Due | &nbsp;&nbsp;&nbsp;Net Fee Due | &nbsp;&nbsp;&nbsp;Net Fee Due | &nbsp;&nbsp;&nbsp;Net Fee Due |  |  |  | $13947.57 |

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(1) This registration statement covers a total of 4,644,456 ordinary shares with a nominal value of CHF 0.01 per
share of Oculis Holding AG ("Ordinary Shares") that are issuable under the Stock Option and Incentive Plan Regulation 2023 (the "Plan"). Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities
Act"), this registration statement shall also cover any additional Ordinary Shares which may become issuable by reason of any share split, share dividend, recapitalizations, or any other similar transaction effected without consideration which
results in an increase in the number of the outstanding Ordinary Shares.

(2) Estimated solely for the purpose of calculating the registration fee, based on the average of the high and low
prices of the Ordinary Shares on The Nasdaq Stock Market LLC on May 29, 2025 ($19.62 per Ordinary Share). This calculation is in accordance with Rules 457(c) and 457(h) of the Securities Act.