# EDGAR Filing Document

**Accession Number:** 0001796280
**File Stem:** 0000950170-25-082520
**Filing Date:** 2025-6
**Character Count:** 42017
**Document Hash:** d3ff6f77463705160df95c378c7a5f91
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000950170-25-082520.hdr.sgml**: 20250605

**ACCESSION NUMBER**: 0000950170-25-082520

**CONFORMED SUBMISSION TYPE**: SCHEDULE 13D

**PUBLIC DOCUMENT COUNT**: 3

**FILED AS OF DATE**: 20250605

**DATE AS OF CHANGE**: 20250605

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Oric Pharmaceuticals, Inc.
- **CENTRAL INDEX KEY:** 0001796280
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 471787157
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SCHEDULE 13D
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-91490
- **FILM NUMBER:** 251028164

**BUSINESS ADDRESS:**
- **STREET 1:** 240 E. GRAND AVE.
- **STREET 2:** 2ND FLOOR
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080
- **BUSINESS PHONE:** (650) 388-5600

**MAIL ADDRESS:**
- **STREET 1:** 240 E. GRAND AVE.
- **STREET 2:** 2ND FLOOR
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** SR ONE CAPITAL MANAGEMENT, LLC
- **CENTRAL INDEX KEY:** 0001853723

**ORGANIZATION NAME:**
- **EIN:** 843383413
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SCHEDULE 13D

**BUSINESS ADDRESS:**
- **STREET 1:** 985 OLD EAGLE SCHOOL ROAD
- **STREET 2:** SUITE 511
- **CITY:** WAYNE
- **STATE:** PA
- **ZIP:** 19087
- **BUSINESS PHONE:** (610) 766-2240

**MAIL ADDRESS:**
- **STREET 1:** 985 OLD EAGLE SCHOOL ROAD
- **STREET 2:** SUITE 511
- **CITY:** WAYNE
- **STATE:** PA
- **ZIP:** 19087

### Attached PDF Documents

**Attachment 1:** `ck0000000000-ex99_1.pdf`

EXHIBIT 1

# AGREEMENT

Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, the undersigned hereby agree that only one statement containing the information required by Schedule 13D need be filed with respect to the ownership by each of the undersigned of shares of stock of ORIC Pharmaceuticals, Inc.

EXECUTED this 5th day of June, 2025.

SR ONE CAPITAL MANAGEMENT, LLC

By: _*
Simeon George, M.D.
Managing Member

SR ONE CAPITAL OPPORTUNITIES FUND I, LP

By: SR ONE CAPITAL OPPORTUNITIES PARTNERS I, LP

By: SR ONE CAPITAL MANAGEMENT, LLC

By: _*
Simeon George, M.D.
Managing Member

SR ONE CAPITAL OPPORTUNITIES PARTNERS I, LP

By: SR ONE CAPITAL MANAGEMENT, LLC

By: _*
Simeon George, M.D.
Managing Member

AMZL, LP

By: SR ONE CAPITAL SMA PARTNERS, LP

By: SR ONE CAPITAL MANAGEMENT, LLC

By: _*
Simeon George, M.D.
Managing Member

SR ONE CAPITAL SMA PARTNERS, LP

By: SR ONE CAPITAL MANAGEMENT, LLC

By: _*
Simeon George, M.D.
Managing Member

SR ONE CAPITAL FUND II AGGREGATOR, LP

By: SR ONE CAPITAL PARTNERS II, LP

By: SR ONE CAPITAL MANAGEMENT, LLC

By: *
Simeon George, M.D.
Managing Member

SR ONE CAPITAL PARTNERS II, LP

By: SR ONE CAPITAL MANAGEMENT, LLC

By: *
Simeon George, M.D.
Managing Member

*

Simeon George, M.D.

*/s/ Sasha Keough
Sasha Keough
As attorney-in-fact

This Agreement relating to Schedule 13D was executed by Sasha Keough on behalf of the individuals listed above pursuant to a Power of Attorney a copy of which is attached hereto as Exhibit 2.

**Attachment 2:** `ck0000000000-ex99_2.pdf`

EXHIBIT 2

# LIMITED POWER OF ATTORNEY

Know all by these presents, that the undersigned hereby makes, constitutes and appoints Sasha Keough, Karen Narolewski-Engel, James Macadam, and Alexander M. Bowling, and each of them singly, as each of the undersigned’s true and lawful attorneys-in-fact with full power and authority as hereinafter described to:

1. execute for and on behalf of each of the undersigned individual and entities (each, a “Filer” and collectively, the “Filers”) (i) Forms 3, 4, and 5 (including amendments thereto) in accordance with Section 16(a) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and the rules thereunder, (ii) Form 144 in accordance with Rule 144 under the Securities Act of 1933, as amended (the “Securities Act”), and (iii) Schedules 13D and 13G (including amendments thereto) in accordance with Sections 13(d) and 13(g) of the Exchange Act and the rules thereunder;

2. do and perform any and all acts for and on behalf of each of the Filers which may be necessary or desirable to complete and execute any such Form 3, 4, or 5 (including amendments thereto), Form 144, or Schedule 13D or 13G (including amendments thereto) and timely file such form with the United States Securities and Exchange Commission (the “SEC”) and any stock exchange or similar authority, including, but not limited to, executing a Form ID or Update Passphrase request for and on behalf of each of the undersigned and filing such applications with the SEC; and

3. take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit to, in the best interest of, or legally required by, a Filer, it being understood that the documents executed by such attorney-in-fact on behalf of such Filer pursuant to this Limited Power of Attorney shall be in such form and shall contain such terms and conditions as such attorney-in-fact may approve in such attorney-in-fact’s discretion.

Each of the Filers hereby grants to each attorney-in-fact full power and authority to do and perform any and every act and thing whatsoever requisite, necessary, or proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes a Filer might or could do if personally present, with full power of substitution or revocation, hereby ratifying and confirming all the acts such attorney-in-fact, or such attorney-in-fact’s substitute or substitutes, shall lawfully do or cause to be done by virtue of this Limited Power of Attorney and the rights and powers herein granted. Each of the Filers acknowledges that each of the foregoing attorneys-in-fact, in serving in such capacity at the request of such Filer, is not assuming any of such Filer’s responsibilities to comply with Sections 13 or 16 of the Exchange Act or Rule 144 under the Securities Act.

This Limited Power of Attorney shall remain in full force and effect until a Filer is no longer required to file Forms 3, 4, and 5 (including amendments thereto), Form 144, and Schedules 13D and 13G (including amendments thereto) with respect to such Filer’s holdings of and transactions in securities, unless earlier revoked by such Filer in a signed writing delivered to each of the foregoing attorneys-in-fact. In addition, at such time as any attorney-in-fact resigns as attorney-in-fact by the execution of a written resignation delivered to each Filer, without any action on the part of the Filers, this Limited Power of Attorney shall be partially revoked solely with respect to such individual; such individual shall cease to be an attorney-in-fact under this Limited Power of Attorney; and the authority of the other attorneys-in-fact then existing hereunder shall remain in full force and effect.

[Signature page follows]

IN WITNESS WHEREOF, each of the undersigned has caused this Limited Power of Attorney to be executed as of this 12th day of December, 2022.

/s/ Simeon George
Simeon George (Individually)

SR One Capital Management, LLC,
a Delaware limited liability company

By: /s/ Simeon George
Simeon George, Managing Member

SR One Capital Fund I Aggregator, LP,
a Delaware limited partnership

By: SR One Capital Partners I, LP,
a Delaware limited partnership
Its: General Partner

By: SR One Capital Management, LLC,
a Delaware limited liability company
Its: General Partner

By: /s/ Simeon George
Simeon George, Managing Member

SR One Capital Partners I, LP,
a Delaware limited partnership

By: SR One Capital Management, LLC
a Delaware limited liability company
Its: General Partner

By: /s/ Simeon George
Simeon George, Managing Member

SR One Capital Fund II Aggregator, LP,
a Delaware limited partnership

By: SR One Capital Partners II, LP,
a Delaware limited partnership
Its: General Partner

By: SR One Capital Management, LLC,
a Delaware limited liability company
Its: General Partner

By: /s/ Simeon George
Simeon George, Managing Member

SR One Capital Partners II, LP,
a Delaware limited partnership

By: SR One Capital Management, LLC
a Delaware limited liability company
Its: General Partner

By: /s/ Simeon George
Simeon George, Managing Member

SR One Capital Opportunities Fund I, LP,
a Delaware limited partnership

By: SR One Capital Opportunities Partners I, LP, a Delaware limited partnership
Its: General Partner

By: SR One Capital Management, LLC,
a Delaware limited liability company
Its: General Partner

By: /s/ Simeon George
Simeon George, Managing Member

SR One Capital Opportunities Partners I, LP,
a Delaware limited partnership

By: SR One Capital Management, LLC
a Delaware limited liability company

Its: General Partner

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest I Manager, LLC,
a Delaware limited liability company

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest I, LLC,
a Delaware limited liability company

By: SR One Co-Invest I Manager, LLC,
a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest II Manager, LLC,
a Delaware limited liability company

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest II, LLC,
a Delaware limited liability company

By: SR One Co-Invest II Manager, LLC,
a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest III Manager, LLC,
a Delaware limited liability company

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest III, LLC,
a Delaware limited liability company

By: SR One Co-Invest III Manager, LLC,
a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest IV Manager, LLC,
a Delaware limited liability company

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest IV, LLC,
a Delaware limited liability company

By: SR One Co-Invest IV Manager, LLC,
a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest IV-A, LLC,
a Delaware limited liability company

By: SR One Co-Invest IV Manager, LLC,
a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest V Manager, LLC,
a Delaware limited liability company

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest V, LLC,
a Delaware limited liability company

By: SR One Co-Invest V Manager, LLC,
a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest VI Manager, LLC,
a Delaware limited liability company

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest VI, LLC,
a Delaware limited liability company

By: SR One Co-Invest VI Manager, LLC,
a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest VII Manager, LLC,
a Delaware limited liability company

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest VII, LLC,
a Delaware limited liability company

By: SR One Co-Invest VII Manager, LLC,
a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest VIII Manager, LLC,
a Delaware limited liability company

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest VIII, LLC,
a Delaware limited liability company

By: SR One Co-Invest VIII Manager, LLC,
a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest IX Manager, LLC,
a Delaware limited liability company

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest IX, LLC,
a Delaware limited liability company

By: SR One Co-Invest IX Manager, LLC,
a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest X Manager, LLC,
a Delaware limited liability company

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest X, LLC,
a Delaware limited liability company

By: SR One Co-Invest X Manager, LLC,
a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest XI Manager, LLC,
a Delaware limited liability company

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest XI, LLC,
a Delaware limited liability company

By: SR One Co-Invest XI Manager, LLC,
a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest XII Manager, LLC,
a Delaware limited liability company

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest XII, LLC,
a Delaware limited liability company

By: SR One Co-Invest XII Manager, LLC,
a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest XIII Manager, LLC,
a Delaware limited liability company

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest XIII, LLC,
a Delaware limited liability company

By: SR One Co-Invest XIII Manager, LLC,
a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest XIV Manager, LLC,
a Delaware limited liability company

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest XIV, LLC,
a Delaware limited liability company

By: SR One Co-Invest XIV Manager, LLC,
a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest XV Manager, LLC,
a Delaware limited liability company

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

SR One Co-Invest XV, LLC,
a Delaware limited liability company

By: SR One Co-Invest XV Manager, LLC,
a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,
a Delaware limited liability company

Its: Managing Member

By: /s/ Simeon George
Simeon George, Managing Member

### UNITED STATES SECURITIES AND EXCHANGE COMMISSION
**Washington, D.C. 20549**

## SCHEDULE 13D

### Under the Securities Exchange Act of 1934

**ORIC Pharmaceuticals, Inc.**

*(Name of Issuer)*

**Common Stock, par value $0.0001 per share**

*(Title of Class of Securities)*

**68622P109**

*(CUSIP Number)*

**Sasha Keough**<br>c/o SR One Capital Management, LP<br>985 Old Eagle School Road, Suite 511<br>Wayne PA 19087<br>(410) 800-7503

*(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)*

**05/29/2025**

*(Date of Event Which Requires Filing of this Statement)*

| **CUSIP No.** | **68622P109** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**SR One Capital Management, LLC** | Name of reporting person<br>**SR One Capital Management, LLC** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**4615384.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**4615384.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**4615384.00** | Aggregate amount beneficially owned by each reporting person<br>**4615384.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**5.4%** | Percent of class represented by amount in Row (11)<br>**5.4%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**OO** | Type of Reporting Person (See Instructions)<br>**OO** | |

---

| **CUSIP No.** | **68622P109** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**SR One Capital Opportunities Fund I, LP** | Name of reporting person<br>**SR One Capital Opportunities Fund I, LP** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**WC** | Source of funds (See Instructions)<br>**WC** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**2382064.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**2382064.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**2382064.00** | Aggregate amount beneficially owned by each reporting person<br>**2382064.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**2.8%** | Percent of class represented by amount in Row (11)<br>**2.8%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**PN** | Type of Reporting Person (See Instructions)<br>**PN** | |

---

| **CUSIP No.** | **68622P109** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**SR One Capital Opportunities Partners I, LP** | Name of reporting person<br>**SR One Capital Opportunities Partners I, LP** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**2382064.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**2382064.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**2382064.00** | Aggregate amount beneficially owned by each reporting person<br>**2382064.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**2.8%** | Percent of class represented by amount in Row (11)<br>**2.8%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**PN** | Type of Reporting Person (See Instructions)<br>**PN** | |

---

| **CUSIP No.** | **68622P109** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**AMZL, LP** | Name of reporting person<br>**AMZL, LP** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**WC** | Source of funds (See Instructions)<br>**WC** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**1538461.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**1538461.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**1538461.00** | Aggregate amount beneficially owned by each reporting person<br>**1538461.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**1.8%** | Percent of class represented by amount in Row (11)<br>**1.8%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**PN** | Type of Reporting Person (See Instructions)<br>**PN** | |

---

| **CUSIP No.** | **68622P109** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**SR One Capital SMA Partners, LP** | Name of reporting person<br>**SR One Capital SMA Partners, LP** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**1538461.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**1538461.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**1538461.00** | Aggregate amount beneficially owned by each reporting person<br>**1538461.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**1.8%** | Percent of class represented by amount in Row (11)<br>**1.8%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**PN** | Type of Reporting Person (See Instructions)<br>**PN** | |

---

| **CUSIP No.** | **68622P109** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**SR One Capital Fund II Aggregator, LP** | Name of reporting person<br>**SR One Capital Fund II Aggregator, LP** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**WC** | Source of funds (See Instructions)<br>**WC** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**694859.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**694859.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**694859.00** | Aggregate amount beneficially owned by each reporting person<br>**694859.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**0.8%** | Percent of class represented by amount in Row (11)<br>**0.8%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**PN** | Type of Reporting Person (See Instructions)<br>**PN** | |

---

| **CUSIP No.** | **68622P109** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**SR One Capital Partners II, LP** | Name of reporting person<br>**SR One Capital Partners II, LP** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**694859.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**694859.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**694859.00** | Aggregate amount beneficially owned by each reporting person<br>**694859.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**0.8%** | Percent of class represented by amount in Row (11)<br>**0.8%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**PN** | Type of Reporting Person (See Instructions)<br>**PN** | |

---

| **CUSIP No.** | **68622P109** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**Simeon George** | Name of reporting person<br>**Simeon George** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**X1** | Citizenship or place of organization<br>**X1** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**4615384.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**4615384.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**4615384.00** | Aggregate amount beneficially owned by each reporting person<br>**4615384.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**5.4%** | Percent of class represented by amount in Row (11)<br>**5.4%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**IN** | Type of Reporting Person (See Instructions)<br>**IN** | |

---

**Item 1. Security and Issuer**

**(a) Title of Class of Securities:**
Common Stock, par value $0.0001 per share

**(b) Name of Issuer:**
ORIC Pharmaceuticals, Inc.

**(c) Address of Issuer's Principal Executive Offices:**
240 E. Grand Ave, 2nd Floor, South San Francisco, CA, 94080

This statement on Schedule 13D (this "Statement") relates to the shares of common stock, par value $0.0001 per share ("Common Stock"), of ORIC Pharmaceuticals, Inc. (the "Issuer").

**Item 4. Purpose of Transaction**

The Funds acquired their respective shares for investment purposes. Depending on market conditions, their continuing evaluation of the business and prospects of the Issuer and other factors, the Funds and other Reporting Persons may dispose of or acquire additional shares of the Issuer. Except as set forth above, none of the Reporting Persons has any present plans which relate to or would result in:
(a) The acquisition by any person of additional securities of the Issuer, or the disposition of securities of the Issuer;
(b) An extraordinary corporate transaction, such as a merger, reorganization or liquidation, involving the Issuer or any of its subsidiaries;
(c) A sale or transfer of a material amount of assets of the Issuer or any of its subsidiaries;
(d) Any change in the present board of directors or management of the Issuer, including any plans or proposals to change the number or term of directors or to fill any existing vacancies on the board;
(e) Any material change in the present capitalization or dividend policy of the Issuer;
(f) Any other material change in the Issuer's business or corporate structure;
(g) Changes in the Issuer's charter, bylaws or instruments corresponding thereto or other actions which may impede the acquisition of control of the Issuer by any person;
(h) Causing a class of securities of the Issuer to be delisted from a national securities exchange or to cease to be authorized to be quoted in an inter-dealer quotation system of a registered national securities association;
(i) A class of equity securities of the Issuer becoming eligible for termination of registration pursuant to Section 12(g)(4) of the Securities Exchange Act of 1934; or
(j) Any action similar to any of those enumerated above.

**Item 5. Interest in Securities of the Issuer**

**(a)**
SR One Opportunities Fund I is the record owner of the SR One Opportunities Fund I Shares. As the general partner of SR One Opportunities Fund I, SR One Opportunities Partners I may be deemed to beneficially own the SR One Opportunities Fund I Shares. As the general partner of SR One Opportunities Partners I, SR One Capital Management may be deemed to beneficially own the SR One Opportunities Fund I Shares. As the managing member of SR One Capital Management, Dr. George may be deemed to beneficially own the SR One Opportunities Fund I Shares.

AMZL is the record owner of the AMZL Shares. As the general partner of AMZL, SMA Partners may be deemed to beneficially own the AMZL Shares. As the general partner of SMA Partners, SR One Capital Management may be deemed to beneficially own the AMZL Shares. As the managing member of SR One Capital Management, Dr. George may be deemed to beneficially own the AMZL Shares.

SR One Fund II Aggregator is the record owner of the SR One Fund II Aggregator Shares. As the general partner of SR One Fund II Aggregator, SR One Partners II may be deemed to beneficially own the SR One Fund II Aggregator Shares. As the general partner of SR One Partners II, SR One Capital Management may be deemed to beneficially own the SR One Fund II Aggregator Shares. As the managing member of SR One Capital Management, Dr. George may be deemed to beneficially own the SR One Fund II Aggregator Shares.

Each Reporting Person disclaims beneficial ownership of the Fund Shares other than those shares which such person owns of record.

The percentage of outstanding shares of Common Stock which may be deemed to be beneficially owned by each Reporting Person is set forth on Line 13 of such Reporting Person's cover sheet. Such percentage was calculated based on 85,318,848 shares of Common Stock, which includes the sum of (i) 71,088,080 shares of Common Stock reported by the Issuer to be outstanding as of April 18, 2025, on the Issuer's Form 10-Q filed with the SEC on May 5, 2025, (ii) 14,130,313 shares of Common Stock reported by the Issuer to be sold pursuant to the Securities Purchase Agreement as reported on the Form 8-K and (iii) the number of shares of Common Stock underlying Pre-Funded Warrants such Reporting Person is deemed to beneficially own (taking into account the Beneficial Ownership Limitation).

**(b)**
(i) sole power to vote or to direct the vote: See line 7 of cover sheets

(ii) shared power to vote or to direct the vote: See line 8 of cover sheets

(iii) sole power to dispose or to direct the disposition: See line 9 of cover sheets

(iv) shared power to dispose or to direct the disposition: See line 10 of cover sheets

**(c)**
Except as set forth in Item 3 above, none of the Reporting Persons has effected any transaction in shares of Common Stock during the last 60 days.

**Item 6. Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer.**

Information with respect to the Private Placement set forth in Item 3 above is incorporated herein by reference to the extent responsive to this Item 6.

### SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** SR One Capital Management, LLC

**Signature:** /s/ Sasha Keough

**Name/Title:** Sasha Keough, as attorney-in-fact for Simeon George, M.D., Managing Member

**Date:** 06/05/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** SR One Capital Opportunities Fund I, LP

**Signature:** /s/ Sasha Keough

**Name/Title:** Sasha Keough, as attorney-in-fact for Simeon George, M.D., Managing Member

**Date:** 06/05/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** SR One Capital Opportunities Partners I, LP

**Signature:** /s/ Sasha Keough

**Name/Title:** Sasha Keough, as attorney-in-fact for Simeon George, M.D., Managing Member

**Date:** 06/05/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** AMZL, LP

**Signature:** /s/ Sasha Keough

**Name/Title:** Sasha Keough, as attorney-in-fact for Simeon George, M.D., Managing Member

**Date:** 06/05/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** SR One Capital SMA Partners, LP

**Signature:** /s/ Sasha Keough

**Name/Title:** Sasha Keough, as attorney-in-fact for Simeon George, M.D., Managing Member

**Date:** 06/05/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** SR One Capital Fund II Aggregator, LP

**Signature:** /s/ Sasha Keough

**Name/Title:** Sasha Keough, as attorney-in-fact for Simeon George, M.D., Managing Member

**Date:** 06/05/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** SR One Capital Partners II, LP

**Signature:** /s/ Sasha Keough

**Name/Title:** Sasha Keough, as attorney-in-fact for Simeon George, M.D., Managing Member

**Date:** 06/05/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** Simeon George

**Signature:** /s/ Sasha Keough

**Name/Title:** Sasha Keough, as attorney-in-fact for Simoen George, M.D.

**Date:** 06/05/2025