# EDGAR Filing Document

**Accession Number:** 0001576280
**File Stem:** 0001576280-25-000245
**Filing Date:** 2025-7
**Character Count:** 30669
**Document Hash:** 769de4364e926a5f3be3350f77e9da6a
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001576280-25-000245.hdr.sgml**: 20250730

**ACCESSION NUMBER**: 0001576280-25-000245

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 14

**CONFORMED PERIOD OF REPORT**: 20250730

**ITEM INFORMATION**: Results of Operations and Financial Condition

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20250730

**DATE AS OF CHANGE**: 20250730

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Guardant Health, Inc.
- **CENTRAL INDEX KEY:** 0001576280
- **STANDARD INDUSTRIAL CLASSIFICATION:** SERVICES-MEDICAL LABORATORIES [8071]
- **ORGANIZATION NAME:** 08 Industrial Applications and Services
- **EIN:** 454139254
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-38683
- **FILM NUMBER:** 251167087

**BUSINESS ADDRESS:**
- **STREET 1:** 3100 HANOVER STREET
- **CITY:** PALO ALTO
- **STATE:** CA
- **ZIP:** 94304
- **BUSINESS PHONE:** 855-698-8887

**MAIL ADDRESS:**
- **STREET 1:** 3100 HANOVER STREET
- **CITY:** PALO ALTO
- **STATE:** CA
- **ZIP:** 94304

?xml version='1.0' encoding='ASCII'? gh-20250730

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549** 

**FORM 8-K** 

**CURRENT REPORT**

**Pursuant to Section 13 or 15(d)**

**of the Securities Exchange Act of 1934**

Date of report (Date of earliest event reported): July 30, 2025

**GUARDANT HEALTH, INC.** 

**(Exact name of registrant as specified in its charter)**

---

| | | |
|:---|:---|:---|
| **Delaware** | **001-38683** | **45-4139254** |
| **(State or other jurisdiction**<br>**of incorporation or organization)** | **(Commission**<br>**File Number)** | **(I.R.S. Employer**<br>**Identification No.)** |

---

**3100 Hanover Street** 

**Palo Alto, California 94304** 

**(Address of principal executive offices) (Zip Code)**

**855-698-8887** 

**(Registrant's telephone number, include area code)**

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

---

| | | |
|:---|:---|:---|
| **Title of each class** | **Trading Symbol(s)** | **Name of each exchange on which registered** |
| **Common Stock, $0.00001 par value per share** | **GH** | **The Nasdaq Global Select Market** |

---

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

------

**Item 2.02 Results of Operations and Financial Condition.** 

On July 30, 2025, Guardant Health, Inc. (the "Company") issued a press release announcing financial results for the fiscal quarter ended June 30, 2025. The full text of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated herein by reference.

The information furnished in this Current Report on Form 8-K (including Exhibit 99.1) shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liabilities of that Section, nor shall it be deemed to be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such filing.

**Item 9.01 Financial Statements and Exhibits.**

(d) Exhibits.

---

| | |
|:---|:---|
| **Exhibit No.** | **Description** |
| 99.1 | <u>[Press release of Guardant Health, Inc., dated July 30, 2025](gh-6302025xexhibit991.htm)</u> |
| 104 | Cover Page Interactive Data File (embedded within the Inline XBRL document) |

---

**SIGNATURES** 

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

---

| | | | |
|:---|:---|:---|:---|
| | | **GUARDANT HEALTH, INC.** | **GUARDANT HEALTH, INC.** |
| Date: | July 30, 2025 | By: | /s/ Michael Bell |
|  |  |  | Michael Bell |
|  |  |  | Chief Financial Officer |
|  |  |  | (Principal Accounting Officer and Principal Financial Officer) |

---

## Exhibit 99.1

![guardantlogoa01.gif](guardantlogoa01.gif)

**Guardant Health Reports Second Quarter 2025 Financial Results and Increases 2025 Revenue Guidance**

*Revenue growth of 31% broadly driven by strong performance across Oncology, Screening, and Biopharma & Data*

*Raises 2025 revenue guidance to $915 to $925 million, representing growth of 24% to 25%* 

**PALO ALTO, Calif.** July 30, 2025 – Guardant Health, Inc. (Nasdaq: GH), a leading precision oncology company, today reported financial results for the quarter ended June 30, 2025.

**Second Quarter 2025 Financial Highlights**

For the three-month period ended June 30, 2025, as compared to the same period of 2024:

• Reported total revenue of $232.1 million, an increase of 31%, driven by:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;◦ Oncology revenue of $158.7 million, an increase of 22%, and approximately 64,000 oncology tests, an increase of 30%

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;◦ Screening revenue of $14.8 million, and approximately 16,000 Shield screening tests

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;◦ Biopharma & Data revenue of $56.0 million, an increase of 28%

• Generated non-GAAP gross margin of 66%, compared to 60% in the second quarter of 2024

• Guardant360 Tissue average selling price increased to approximately $2,000, achieving 2028 target three years ahead of schedule

**Recent Operating Highlights**

• Introduced 11 groundbreaking Smart Liquid Biopsy applications for Guardant360 Liquid that greatly expands the differentiated clinical utility for therapy selection

• Submitted Reveal breast cancer package to MolDx for Medicare reimbursement following publication in *ESMO Open*

• Published RADIOHEAD immuno-oncology monitoring study for Reveal in *Cancer Research Communications*, with data from 521 stage IV pan-cancer patients

• Expanded Oncology offerings with launches of Guardant Hereditary Cancer Testing and a suite of immunohistochemistry tests

• Shield included in the updated National Comprehensive Cancer Network, or NCCN, colorectal cancer screening guidelines

• Enrollment commenced for NCI Vanguard study for Shield Multi-Cancer Detection (MCD)

• Shield MCD granted Breakthrough Device Designation from the FDA

• Shield named a winner of Fast Company's 2025 World Changing Ideas Awards

"Q2 was another exceptional quarter for Guardant and we were able to increase our 2025 revenue guidance yet again. We saw especially strong performance from Guardant360 Liquid, where year-over-year growth accelerated for the fourth consecutive quarter," said Helmy Eltoukhy, co-founder and co-CEO. "In May, we introduced 11 groundbreaking Smart Liquid Biopsy applications for Guardant360 Liquid, significantly expanding the clinical utility. Product innovation built on Smart Liquid Biopsy is integral to our strategy at Guardant and we look forward to continuing a steady cadence of SLB-based applications to further extend our technical leadership in the comprehensive genomic profiling market."

"Shield continued to generate strong demand in its third full quarter of commercial launch. Shield volume, revenue and gross profit grew strongly, ahead of our expectations, paving the path for faster acceleration of commercial infrastructure buildout," said AmirAli Talasaz, co-founder and co-CEO. "Beyond CRC, we are making important progress with Shield as a multi-cancer detection test. Shield MCD test recently received Breakthrough Device Designation from the FDA and surpassed an important milestone with the start of the NCI Vanguard study."

**Second Quarter 2025 Financial Results**

Revenue was $232.1 million for the second quarter of 2025, a 31% increase from $177.2 million for the corresponding prior year period. Oncology revenue grew 22% to $158.7 million for the second quarter of 2025, from $130.3 million for the corresponding prior year period, driven primarily by an increase in Oncology test volume (Guardant360 Liquid & Tissue, Reveal and Response), which grew 30% over the prior year period. The increase in Oncology revenue was also attributable to an increase in reimbursement for our Oncology tests. Screening revenue was $14.8 million for the second quarter of 2025, generated from approximately 16,000 Shield screening tests. Biopharma and Data revenue grew 28% to $56.0 million for the second quarter of 2025, from $43.9 million for the corresponding prior year period, driven primarily by an increase in volume of tests and an increase in average selling price of our GuardantINFINITY test, as well as an increase in revenue derived from service agreements with biopharmaceutical customers. Licensing and other revenue was $2.6 million for the second quarter of 2025, compared to $3.0 million for the corresponding prior year period.

------

![guardantlogoa01.gif](guardantlogoa01.gif)

Gross profit, or total revenue less cost of revenue, was $150.9 million for the second quarter of 2025, an increase of $46.1 million from $104.8 million for the corresponding prior year period. Gross margin, or gross profit divided by total revenue, was 65%, as compared to 59% for the corresponding prior year period.

Non-GAAP gross profit was $153.8 million for the second quarter of 2025, an increase of $47.0 million or 44%, from $106.8 million for the corresponding prior year period. Non-GAAP gross margin was 66% for the second quarter of 2025, as compared to 60% for the corresponding prior year period.

Operating expenses were $257.3 million for the second quarter of 2025, as compared to $205.4 million for the corresponding prior year period. The year-over-year increase in operating expenses was primarily related to commercial team expansion and marketing activities to support the Shield product launch and existing products, as well as an increase in stock-based compensation expense. Non-GAAP operating expenses were $215.3 million for the second quarter of 2025, as compared to $178.8 million for the corresponding prior year period. The year-over-year increase in non-GAAP operating expenses was primarily related to commercial team expansion and marketing activities to support the Shield product launch and existing products.

Net loss was $99.9 million for the second quarter of 2025, as compared to $102.6 million for the corresponding prior year period. Net loss per share was $0.80 for the second quarter of 2025, as compared to $0.84 for the corresponding prior year period.

Non-GAAP net loss was $55.0 million for the second quarter of 2025, as compared to $58.5 million for the corresponding prior year period. Non-GAAP net loss per share was $0.44 for the second quarter of 2025, as compared to $0.48 for the corresponding prior year period.

Adjusted EBITDA loss was $51.9 million for the second quarter of 2025, as compared to a $61.9 million loss for the corresponding prior year period.

Free cash flow for the second quarter of 2025 was $(65.9) million, as compared to $(99.1) million for the corresponding prior year period. The year-over-year reduction was primarily due to a change in timing of the payout of the Company's annual bonus, which was made in the first quarter of 2025 and in the second quarter of 2024.

Cash, cash equivalents, and restricted cash were $735.5 million as of June 30, 2025.

**2025 Guidance**

Guardant Health now expects full year 2025 revenue to be in the range of $915 to $925 million, representing growth of 24% to 25% compared to full year 2024. This compares to the prior range of $880 to $890 million, representing annual growth of 19% to 20%.

Within this revenue range:

• Oncology revenue is now expected to grow approximately 20% year over year in 2025, compared to prior guidance of approximately 18% growth. Oncology volume is now expected to accelerate to greater than 27% growth in 2025 compared to 20% growth in 2024.

• Screening revenue is now expected to be in the range of $55 to $60 million, driven by Shield volume of 68,000 to 73,000 tests. This compares to the prior range of $40 to $45 million and 52,000 to 58,000 tests.

• Biopharma & Data revenue growth is now expected to be in the mid-teens range, compared to prior expectations of low double-digits.

Guardant Health now expects full year 2025 non-GAAP gross margin to be in the range of 63% to 64%, an improvement compared to prior expectations of 62% to 63%. Guardant Health now expects total non-GAAP operating expenses to be in the range of $840 to $850 million, an increase compared to the prior range of $830 to $840 million due to the reinvestment of incremental Screening gross profit to accelerate the Screening commercial infrastructure build out. Guardant Health continues to expect free cash flow burn to be in the range of $225 to $235 million, an improvement compared to $275 million for the full year 2024. This includes approximately $200 million of Screening net cash burn. Guardant Health continues to expect the remainder of the business excluding Screening to reach free cash flow breakeven in the fourth quarter of 2025.

**Webcast Information**

Guardant Health will host a conference call to discuss the second quarter 2025 financial results after market close on Wednesday, July 30, 2025 at 1:30 pm Pacific Time / 4:30 pm Eastern Time. A webcast of the conference call can be accessed at http://investors.guardanthealth.com. The webcast will be archived and available for replay for at least 90 days after the event.

**Non-GAAP Measures**

Guardant Health has presented in this release certain financial information in accordance with U.S. Generally Accepted Accounting Principles (GAAP) and also on a non-GAAP basis, including non-GAAP cost of revenue, non-GAAP gross profit, non-GAAP research and development expense, non-GAAP sales and marketing expense, non-GAAP general and administrative expense, non-

------

![guardantlogoa01.gif](guardantlogoa01.gif)

GAAP loss from operations, non-GAAP net loss, non-GAAP net loss per share, basic and diluted, adjusted EBITDA, and free cash flow.

We define our non-GAAP measures as the applicable GAAP measure adjusted for the impacts of stock-based compensation and related employer payroll tax payments, contingent consideration, amortization of intangible assets, unrealized gains and losses on marketable equity securities, impairment of non-marketable equity securities, gain on extinguishment of convertible notes, and other non-recurring items.

Adjusted EBITDA is defined as net loss adjusted for interest income; interest expense; other income (expense), net; provision for income taxes; depreciation and amortization expense; stock-based compensation expense and related employer payroll tax payments; contingent consideration; and other non-recurring items. Free cash flow is defined as net cash used in operating activities in the period less purchases of property and equipment in the period.

We believe that the exclusion of certain income and expenses in calculating these non-GAAP financial measures can provide a useful measure for investors when comparing our period-to-period core operating results, and when comparing those same results to that published by our peers. We exclude certain items because we believe that these income and expenses do not reflect expected future operating performance. Additionally, certain items are inconsistent in amounts and frequency, making it difficult to perform a meaningful evaluation of our current or past operating performance. We use these non-GAAP financial measures to evaluate ongoing operations, for internal planning and forecasting purposes, and to manage our business.

These non-GAAP financial measures are not intended to be considered in isolation from, as substitute for, or as superior to, the corresponding financial measures prepared in accordance with GAAP. There are limitations inherent in non-GAAP financial measures because they exclude charges and credits that are required to be included in a GAAP presentation, and do not present the full measure of our recorded costs against its revenue. In addition, our definition of the non-GAAP financial measures may differ from non-GAAP measures used by other companies.

**About Guardant Health**

Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn, X (Twitter) and Facebook.

**Forward Looking Statements**

This press release contains forward-looking statements within the meaning of federal securities laws, including statements regarding the potential utilities, values, benefits and advantages of Guardant Health's liquid biopsy tests or assays, which involve risks and uncertainties that could cause the actual results to differ materially from the anticipated results and expectations expressed in these forward-looking statements. These statements are based on current expectations, forecasts and assumptions, and actual outcomes and results could differ materially from these statements due to a number of factors. These and additional risks and uncertainties that could affect Guardant Health's financial and operating results and cause actual results to differ materially from those indicated by the forward-looking statements made in this press release include those discussed under the captions "Risk Factors" and "Management's Discussion and Analysis of Financial Condition and Results of Operation" and elsewhere in its Annual Report on Form 10-K for the year ended December 31, 2024, and in its other reports filed with or furnished to the Securities and Exchange Commission thereafter. The forward-looking statements in this press release are based on information available to Guardant Health as of the date hereof, and Guardant Health disclaims any obligation to update any forward-looking statements provided to reflect any change in its expectations or any change in events, conditions, or circumstances on which any such statement is based, except as required by law. These forward-looking statements should not be relied upon as representing Guardant Health's views as of any date subsequent to the date of this press release.

**<u>Investor Contact:</u>**

Zarak Khurshid

<u>investors@guardanthealth.com</u>

**<u>Media Contact:</u>**

Meaghan Smith

<u>press@guardanthealth.com</u>

------

![guardantlogoa01.gif](guardantlogoa01.gif)

**Guardant Health, Inc.**

**Condensed Consolidated Statements of Operations** 

**(unaudited)**

**(in thousands, except per share data)**

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended June 30,** | **Three Months Ended June 30,** | **Six Months Ended June 30,** | **Six Months Ended June 30,** |
| | **2025** | **2024** | **2025** | **2024** |
| Revenue | $232088 | $177235 | $435559 | $345726 |
| Costs and operating expenses: |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Cost of revenue | 81205 | 72421 | 155928 | 137717 |
| &nbsp;&nbsp;&nbsp;Research and development expense | 87449 | 83102 | 175970 | 166904 |
| &nbsp;&nbsp;&nbsp;Sales and marketing expense | 119588 | 81867 | 223904 | 162292 |
| &nbsp;&nbsp;&nbsp;General and administrative expense | 50259 | 40463 | 97211 | 79114 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total costs and operating expenses | 338501 | 277853 | 653013 | 546027 |
| Loss from operations | (106413) | (100618) | (217454) | (200301) |
| Interest income | 7560 | 13913 | 16672 | 28781 |
| Interest expense | (983) | (645) | (1774) | (1290) |
| Other income (expense), net | (25) | (15145) | 7826 | (44265) |
| Loss before provision for income taxes | (99861) | (102495) | (194730) | (217075) |
| Provision for income taxes | 38 | 133 | 328 | 538 |
| Net loss | $(99899) | $(102628) | $(195058) | $(217613) |
| Net loss per share, basic and diluted | $(0.80) | $(0.84) | $(1.57) | $(1.78) |
| Weighted-average shares used in computing net loss per share, basic and diluted | 124114 | 122447 | 123993 | 122080 |

---

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![guardantlogoa01.gif](guardantlogoa01.gif)

**Guardant Health, Inc.**

**Condensed Consolidated Balance Sheets** 

**(unaudited)**

**(in thousands, except share and per share data)**

---

| | | |
|:---|:---|:---|
| | **June 30, 2025** | **December 31, 2024** |
| **ASSETS** | | |
| Current assets: |  |  |
| &nbsp;&nbsp;&nbsp;Cash and cash equivalents | $629143 | $525540 |
| &nbsp;&nbsp;&nbsp;Short-term marketable debt securities  |  | 314438 |
| &nbsp;&nbsp;&nbsp;Accounts receivable, net | 130252 | 110253 |
| &nbsp;&nbsp;&nbsp;Inventory, net | 84061 | 71083 |
| &nbsp;&nbsp;&nbsp;Prepaid expenses and other current assets, net  | 39976 | 33800 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total current assets  | 883432 | 1055114 |
| Restricted cash | 106337 | 104215 |
| Property and equipment, net  | 126141 | 136813 |
| Right-of-use assets, net | 169768 | 142265 |
| Intangible assets, net  | 5864 | 6760 |
| Goodwill | 3290 | 3290 |
| Other assets, net  | 37167 | 37152 |
| Total Assets | $1331999 | $1485609 |
| **LIABILITIES AND STOCKHOLDERS' DEFICIT** |  |  |
| Current liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;Accounts payable | $44802 | $38551 |
| &nbsp;&nbsp;&nbsp;Accrued compensation | 68262 | 83219 |
| &nbsp;&nbsp;&nbsp;Accrued expenses | 71011 | 68345 |
| &nbsp;&nbsp;&nbsp;Deferred revenue  | 54355 | 35468 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total current liabilities  | 238430 | 225583 |
| Convertible senior notes, net, principal amount of $1,090,660 and $1,150,000 as of June 30, 2025 and December 31, 2024, respectively | 1115526 | 1142547 |
| Long-term operating lease liabilities  | 192348 | 164292 |
| Other long-term liabilities  | 91170 | 92834 |
| Total Liabilities | 1637474 | 1625256 |
| Stockholders' deficit: |  |  |
| &nbsp;&nbsp;&nbsp;Common stock, par value of $0.00001 per share; 350,000,000 shares authorized; 125,454,255 and 123,994,006 shares issued as of June 30, 2025 and December 31, 2024; and 124,477,904 and 123,994,006 shares outstanding as of June 30, 2025 and December 31, 2024, respectively | 1 | 1 |
| &nbsp;&nbsp;&nbsp;Treasury stock, at cost, 976,351 shares as of June 30, 2025  | (45010) |  |
| &nbsp;&nbsp;&nbsp;Additional paid-in capital  | 2516550 | 2443788 |
| &nbsp;&nbsp;&nbsp;Accumulated other comprehensive loss | (3723) | (5201) |
| &nbsp;&nbsp;&nbsp;Accumulated deficit  | (2773293) | (2578235) |
| Total Stockholders' Deficit | (305475) | (139647) |
| Total Liabilities and Stockholders' Deficit | $1331999 | $1485609 |

---

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![guardantlogoa01.gif](guardantlogoa01.gif)

**Guardant Health, Inc.**

**Supplemental Revenue Information**

**(unaudited)**

**(in thousands)**

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended June 30,** | **Three Months Ended June 30,** | **Six Months Ended June 30,** | **Six Months Ended June 30,** |
| | **2025** | **2024** | **2025** | **2024** |
| Oncology | $158685 | $130269 | $309244 | $256017 |
| Biopharma and data | 56020 | 43933 | 101396 | 81520 |
| Screening | 14814 |  | 20491 |  |
| Licensing and other | 2569 | 3033 | 4428 | 8189 |
| **Total revenue** | $232088 | $177235 | $435559 | $345726 |

---

**Reconciliation of Selected GAAP Measures to Non-GAAP Measures**

**(unaudited)**

**(in thousands, except per share data)**

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended June 30,** | **Three Months Ended June 30,** | **Six Months Ended June 30,** | **Six Months Ended June 30,** |
| | **2025** | **2024** | **2025** | **2024** |
| **GAAP cost of revenue** | $81205 | $72421 | $155928 | $137717 |
| &nbsp;&nbsp;&nbsp;Amortization of intangible assets | (150) | (217) | (298) | (566) |
| &nbsp;&nbsp;&nbsp;Stock-based compensation expense and related employer payroll tax payments | (2759) | (1807) | (5149) | (3584) |
| **Non-GAAP cost of revenue** | $78296 | $70397 | $150481 | $133567 |
| **GAAP gross profit** | $150883 | $104814 | $279631 | $208009 |
| &nbsp;&nbsp;&nbsp;Amortization of intangible assets | 150 | 217 | 298 | 566 |
| &nbsp;&nbsp;&nbsp;Stock-based compensation expense and related employer payroll tax payments | 2759 | 1807 | 5149 | 3584 |
| **Non-GAAP gross profit** | $153792 | $106838 | $285078 | $212159 |
| **GAAP research and development expense** | $87449 | $83102 | $175970 | $166904 |
| &nbsp;&nbsp;&nbsp;Stock-based compensation expense and related employer payroll tax payments | (14255) | (10001) | (27345) | (20065) |
| &nbsp;&nbsp;&nbsp;Contingent consideration | (647) | (110) | (1181) | (485) |
| **Non-GAAP research and development expense** | $72547 | $72991 | $147444 | $146354 |
| **GAAP sales and marketing expense** | $119588 | $81867 | $223904 | $162292 |
| &nbsp;&nbsp;&nbsp;Stock-based compensation expense and related employer payroll tax payments | (11756) | (7258) | (21945) | (14587) |
| **Non-GAAP sales and marketing expense** | $107832 | $74609 | $201959 | $147705 |
| **GAAP general and administrative expense** | $50259 | $40463 | $97211 | $79114 |
| &nbsp;&nbsp;&nbsp;Amortization of intangible assets | (266) | (335) | (598) | (671) |
| &nbsp;&nbsp;&nbsp;Stock-based compensation expense and related employer payroll tax payments | (14832) | (8659) | (28403) | (16823) |
| &nbsp;&nbsp;&nbsp;Contingent consideration | (230) | (300) | (720) | (420) |
| &nbsp;&nbsp;&nbsp;Non-recurring other operating expense |  |  | (2000) |  |
| **Non-GAAP general and administrative expense** | $34931 | $31169 | $65490 | $61200 |

---

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![guardantlogoa01.gif](guardantlogoa01.gif)

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended June 30,** | **Three Months Ended June 30,** | **Six Months Ended June 30,** | **Six Months Ended June 30,** |
| | **2025** | **2024** | **2025** | **2024** |
| **GAAP loss from operations** | $(106413) | $(100618) | $(217454) | $(200301) |
| &nbsp;&nbsp;&nbsp;Amortization of intangible assets | 416 | 552 | 896 | 1237 |
| &nbsp;&nbsp;&nbsp;Stock-based compensation expense and related employer payroll tax payments | 43602 | 27725 | 82842 | 55059 |
| &nbsp;&nbsp;&nbsp;Contingent consideration | 877 | 410 | 1901 | 905 |
| &nbsp;&nbsp;&nbsp;Non-recurring other operating expense |  |  | 2000 |  |
| **Non-GAAP loss from operations** | $(61518) | $(71931) | $(129815) | $(143100) |
| **GAAP net loss** | $(99899) | $(102628) | $(195058) | $(217613) |
| &nbsp;&nbsp;&nbsp;Amortization of intangible assets | 416 | 552 | 896 | 1237 |
| &nbsp;&nbsp;&nbsp;Stock-based compensation expense and related employer payroll tax payments | 43602 | 27725 | 82842 | 55059 |
| &nbsp;&nbsp;&nbsp;Contingent consideration | 877 | 410 | 1901 | 905 |
| &nbsp;&nbsp;&nbsp;Non-recurring other operating expense |  |  | 2000 |  |
| &nbsp;&nbsp;&nbsp;Unrealized losses on marketable equity securities |  | 15485 |  | 45539 |
| &nbsp;&nbsp;&nbsp;Impairment of non-marketable equity securities  |  |  | 5000 |  |
| &nbsp;&nbsp;&nbsp;Gain on extinguishment of convertible notes |  |  | (13672) |  |
| **Non-GAAP net loss** | $(55004) | $(58456) | $(116091) | $(114873) |
| **GAAP net loss per share, basic and diluted** | $(0.80) | $(0.84) | $(1.57) | $(1.78) |
| **Non-GAAP net loss per share, basic and diluted** | $(0.44) | $(0.48) | $(0.94) | $(0.94) |
| **Weighted-average shares used in computing GAAP and Non-GAAP net loss per share, basic and diluted** | 124114 | 122447 | 123993 | 122080 |

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**Reconciliation of GAAP Net Loss to Adjusted EBITDA** 

**(unaudited)**

**(in thousands)**

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended June 30,** | **Three Months Ended June 30,** | **Six Months Ended June 30,** | **Six Months Ended June 30,** |
| | **2025** | **2024** | **2025** | **2024** |
| **GAAP net loss** | $(99899) | $(102628) | $(195058) | $(217613) |
| &nbsp;&nbsp;&nbsp;Interest income | (7560) | (13913) | (16672) | (28781) |
| &nbsp;&nbsp;&nbsp;Interest expense | 983 | 645 | 1774 | 1290 |
| &nbsp;&nbsp;&nbsp;Other expense (income), net | 25 | 15145 | (7826) | 44265 |
| &nbsp;&nbsp;&nbsp;Provision for income taxes | 38 | 133 | 328 | 538 |
| &nbsp;&nbsp;&nbsp;Depreciation and amortization | 10042 | 10623 | 20278 | 21335 |
| &nbsp;&nbsp;&nbsp;Stock-based compensation expense and related employer payroll tax payments | 43602 | 27725 | 82842 | 55059 |
| &nbsp;&nbsp;&nbsp;Contingent consideration | 877 | 410 | 1901 | 905 |
| &nbsp;&nbsp;&nbsp;Non-recurring other operating expense |  |  | 2000 |  |
| **Adjusted EBITDA** | $(51892) | $(61860) | $(110433) | $(123002) |

---

**Reconciliation of Free Cash Flow to Net Cash Used in Operating Activities** 

**(unaudited)**

**(in thousands)**

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended June 30,** | **Three Months Ended June 30,** | **Six Months Ended June 30,** | **Six Months Ended June 30,** |
| | **2025** | **2024** | **2025** | **2024** |
| Net cash used in operating activities | $(60285) | $(94002) | $(122974) | $(124286) |
| Purchases of property and equipment | (5649) | (5077) | (10108) | (12011) |
| **Free cash flow** | $(65934) | $(99079) | $(133082) | $(136297) |

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