# EDGAR Filing Document

**Accession Number:** 0001785173
**File Stem:** 0001193125-25-258689
**Filing Date:** 2025-10
**Character Count:** 9479
**Document Hash:** 8a07803fe667af2ae2075d5d57c227c3
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-25-258689.hdr.sgml**: 20251030

**ACCESSION NUMBER**: 0001193125-25-258689

**CONFORMED SUBMISSION TYPE**: S-8 POS

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20251030

**DATE AS OF CHANGE**: 20251030

**EFFECTIVENESS DATE**: 20251030

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** 89bio, Inc.
- **CENTRAL INDEX KEY:** 0001785173
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 831114349
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8 POS
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-237263
- **FILM NUMBER:** 251436253

**BUSINESS ADDRESS:**
- **STREET 1:** 655 MONTGOMERY STREET
- **STREET 2:** SUITE 1500
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94111
- **BUSINESS PHONE:** (415) 432-9270

**MAIL ADDRESS:**
- **STREET 1:** 655 MONTGOMERY STREET
- **STREET 2:** SUITE 1500
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94111

**As filed with the Securities and Exchange Commission on October 30, 2025** 

**Registration No. 333-235577** 

**Registration No. 333-237263** 

**Registration No. 333-254683** 

**Registration No. 333-263838** 

**Registration No. 333-270544** 

**Registration No. 333-277764** 

**Registration No. 333-285381** 

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**WASHINGTON, D.C. 20549** 

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-235577**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-237263**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-254683**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-263838**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement** 

**No. 333-270544**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-277764** 

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-285381** 

***UNDER***

***THE SECURITIES ACT OF 1933***

## 89bio, Inc.
**(Exact name of registrant as specified in its charter)** 

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| | |
|:---|:---|
| **Delaware** | **36-4946844** |
| **(State or Other Jurisdiction of**<br> **Incorporation or Organization)** | **(I.R.S. Employer**<br> **Identification No.)** |

---

**1 DNA Way** 

**South San Francisco, California 94080** 

**(Address of principal executive offices, including zip code)** 

**Amended and Restated 89bio, Inc. 2019 Equity Incentive Plan** 

**89bio, Inc. 2019 Employee Stock Purchase Plan** 

**89bio, Inc. 2023 Inducement Plan** 

**(Full titles of the plans)** 

**Roger Brown** 

**Roche Holdings, Inc.** 

**1 DNA Way** 

**South San Francisco, California 94080** 

**Telephone: (650) 225-1000**

**(Name, address, including zip code, and telephone number, including area code, of agent for service)** 

***Copies to:***

**Sharon R. Flanagan** 

**John H. Butler** 

**Sally Wagner Partin** 

**Daniel J. Belke** 

**Sidley Austin LLP** 

**555 California Street, Suite 2000** 

**San Francisco, California 94104** 

**Telephone: (415) 772-1200**

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

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| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☒ | Accelerated filer | ☐ |
| Non-accelerated filer | ☐ | Smaller reporting company | ☐ |
|  |  | Emerging growth company | ☐ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

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**DEREGISTRATION OF SECURITIES** 

These post-effective amendments (the "***Post-Effective Amendments***"), filed by 89bio, Inc., a Delaware corporation (the "***Company***"), remove from registration all shares of common stock, par value $0.001 per share, of the Company (the "***Common Stock***") previously registered under the following Registration Statements on Form S-8 filed by the Company (the "***Registration Statements***") with the U.S. Securities and Exchange Commission (the "***SEC***") pertaining to the registration of shares of Common Stock.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• [Registration No. 333-235577](http://www.sec.gov/Archives/edgar/data/1785173/000119312519317647/d844962ds8.htm) , which was previously filed with the SEC on December 18, 2019, registering 2,844,193 shares of Common Stock under the 2019 Equity Incentive Plan and 225,188 shares of Common Stock
under the 2019 Employee Stock Purchase Plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• [Registration No. 333-237263](http://www.sec.gov/Archives/edgar/data/1785173/000119312520077307/d901946ds8.htm) , which was previously filed with the SEC on March 18, 2020, registering 551,559 shares of Common Stock under the 2019 Equity Incentive Plan and 137,890 shares of Common Stock under
the 2019 Employee Stock Purchase Plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• [Registration No. 333-254683](http://www.sec.gov/Archives/edgar/data/1785173/000119312521093258/d150638ds8.htm) , which was previously filed with the SEC on March 25, 2021, registering 797,266 shares of Common Stock under the 2019 Equity Incentive Plan and 199,317 shares of Common Stock under
the 2019 Employee Stock Purchase Plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• [Registration No. 333-263838](http://www.sec.gov/Archives/edgar/data/1785173/000119312522084044/d329376ds8.htm) , which was previously filed with the SEC on March 24, 2022, registering 812,688 shares of Common Stock under the 2019 Equity Incentive Plan and 203,172 shares of Common Stock under
the 2019 Employee Stock Purchase Plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• [Registration No. 333-270544](http://www.sec.gov/Archives/edgar/data/1785173/000119312523070647/d446105ds8.htm) , which was previously filed with the SEC on March 15, 2023, registering 2,022,423 shares of Common Stock under the 2019 Equity Incentive Plan, 505,606 shares of Common Stock under the
2019 Employee Stock Purchase Plan, and 1,500,000 shares of Common Stock under the 2023 Inducement Plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• [Registration No. 333-277764](http://www.sec.gov/Archives/edgar/data/1785173/000119312524062530/d809128ds8.htm) , which was previously filed with the SEC on March 8, 2024, registering 3,730,775 shares of Common Stock under the 2019 Equity Incentive Plan and 932,693 shares of Common Stock under
the 2019 Employee Stock Purchase Plan; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• [Registration No. 333-285381](http://www.sec.gov/Archives/edgar/data/1785173/000119312525039435/d886657ds8.htm) , which was previously filed with the SEC on February 27, 2025, registering 4,793,977 shares of Common Stock under the 2019 Equity Incentive Plan and 1,198,494 shares of Common Stock
under the 2019 Employee Stock Purchase Plan.

On September 17, 2025, the Company entered into an Agreement and Plan of Merger (the "***Merger Agreement***") with Roche Holdings, Inc., a Delaware corporation ("***Parent***"), and Bluefin Merger Subsidiary, Inc., a Delaware corporation and a wholly owned subsidiary of Parent ("***Offeror***"). On October 30, 2025, pursuant to the Merger Agreement, Offeror merged with and into the Company, with the Company surviving as a wholly owned subsidiary of Parent (the "***Merger***").

As a result of the Merger, the Company has terminated all offerings of the Company's securities pursuant to the Registration Statements. The Company, by filing these post-effective amendments, hereby terminates the effectiveness of the Registration Statements and removes from registration any and all plan interests and any and all securities registered but unsold or otherwise unissued under the Registration Statements as of the date hereof. This filing is made in accordance with an undertaking made by the Company in each of the Registration Statements to remove from registration by means of a post-effective amendment any securities that had been registered for issuance but remain unsold at the termination of the offering.

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SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused these Post-Effective Amendments to the Registration Statements on Form S-8 to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of South San Francisco, State of California, on this 30th day of October, 2025.

No other person is required to sign these Post-Effective Amendments to the Registration Statements on Form S-8 in reliance upon Rule 478 under the Securities Act of 1933, as amended.

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| | |
|:---|:---|
| **89BIO, INC.** | **89BIO, INC.** |
| By: | /s/ Roger Brown |
|  | Roger Brown |
|  | Vice President, Treasurer and Assistant Secretary |

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