# EDGAR Filing Document

**Accession Number:** 0000872912
**File Stem:** 0001193125-25-181923
**Filing Date:** 2025-8
**Character Count:** 27390
**Document Hash:** bcb3f8c1536a414a6047f557e34a855d
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-25-181923.hdr.sgml**: 20250815

**ACCESSION NUMBER**: 0001193125-25-181923

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 15

**FILED AS OF DATE**: 20250815

**DATE AS OF CHANGE**: 20250815

**EFFECTIVENESS DATE**: 20250815

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** DELCATH SYSTEMS, INC.
- **CENTRAL INDEX KEY:** 0000872912
- **STANDARD INDUSTRIAL CLASSIFICATION:** SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
- **ORGANIZATION NAME:** 08 Industrial Applications and Services
- **EIN:** 061245881
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-289661
- **FILM NUMBER:** 251225319

**BUSINESS ADDRESS:**
- **STREET 1:** 566 QUEENSBURY AVENUE
- **CITY:** QUEENSBURY
- **STATE:** NY
- **ZIP:** 12804
- **BUSINESS PHONE:** (518) 743-8892

**MAIL ADDRESS:**
- **STREET 1:** 566 QUEENSBURY AVENUE
- **CITY:** QUEENSBURY
- **STATE:** NY
- **ZIP:** 12804

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** DELCATH SYSTEMS INC
- **DATE OF NAME CHANGE:** 19990607

**As filed with the Securities and Exchange Commission on August 15, 2025** 

**Registration No. 333-** 

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**Washington, D.C. 20549** 

**FORM S-8**

**REGISTRATION STATEMENT** 

***UNDER***

***THE SECURITIES ACT OF 1933***

## DELCATH SYSTEMS, INC.
**(Exact name of registrant as specified in its charter)** 

---

| | |
|:---|:---|
| **Delaware** | **06-1245881** |
| **(State or other jurisdiction of**<br> **incorporation or organization)** | **(I.R.S. Employer**<br> **Identification No.)** |

---

**566 Queensbury Avenue** 

**Queensbury, NY 12804** 

**(Address of Principal Executive Offices) (Zip Code)** 

**Delcath Systems, Inc. Omnibus 2020 Equity Incentive Plan** 

**Delcath Systems, Inc. 2021 Employee Stock Purchase Plan** 

**Delcath Systems, Inc. 2023 Inducement Plan** 

**(Full title of the plan)** 

**Gerard Michel** 

**Chief Executive Officer** 

**Delcath Systems, Inc.** 

**566 Queensbury Avenue** 

**Queensbury, NY 12804** 

**(Name, address, including zip code, and telephone number, including area code, of agent for service)** 

**(212) 489-2100**

**(Telephone number, including area code, of agent for service)** 

***Copies to:***

---

| | |
|:---|:---|
| **David Hoffman**<br> **General Counsel**<br> **Delcath Systems, Inc.**<br> **566 Queensbury Avenue**<br> **Queensbury, NY 12804** | **Ryan Sansom**<br> **Christina Roupas**<br> **Cooley LLP**<br> **500 Boylston Street**<br> **Boston, MA 02116-3736**<br> **(617) 937 2335** |

---

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☐ | Accelerated filer | ☐ |
| Non-accelerated filer | ☒ | Smaller reporting company | ☒ |
|  |  | Emerging growth company | ☐ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

------

**INTRODUCTION** 

This Registration Statement on Form S-8 is being filed by Delcath Systems, Inc. (the "Registrant" or the "Company") for the purposes of registering an additional 2,950,000 shares (the "Shares") of the Company's common stock, par value $0.01 per share (the "Common Stock") consisting of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• 2,200,000 shares of Common Stock issuable under the Company's Omnibus 2020 Equity Incentive Plan, as
amended (the "2020 EIP" and such amendment, the "2020 EIP Amendment");

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• 300,000 shares of Common Stock issuable under the Company's 2021 Employee Stock Purchase Plan, as amended
(the "2021 ESPP" and such amendment, the "2021 ESPP Amendment"); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• 450,000 shares of Common Stock issuable under the Company's 2023 Inducement Awards Plan (the
"Inducement Plan" and such amendment, the "Inducement Plan Amendment").

The 2020 EIP Amendment and 2021 ESPP Amendment were adopted by the Company's Board of Directors on February 7, 2025, subject to stockholder approval, which was obtained at the Annual Meeting of Stockholders held on May 15, 2025. The Inducement Plan Amendment was adopted by the Company's Board of Directors on February 5, 2025 and May 14, 2025.

The Shares being registered are in addition to the shares of Common Stock registered on (i) the Registrant's [Form S-8](http://www.sec.gov/Archives/edgar/data/872912/000119312520319024/d16217ds8.htm) filed with the Commission on December 16, 2020 (File No. 333-251385), (ii) the Registrant's [Form S-8](http://www.sec.gov/Archives/edgar/data/872912/000119312522002698/d267846ds8.htm) filed with the Commission on January 5, 2022 (File No. 333-262022), (iii) the Registrant's [Form S-8](http://www.sec.gov/Archives/edgar/data/872912/000119312522159662/d296604ds8.htm) filed with the Commission on May 25, 2022 (File No. 333-265202) and (iv) the Registrant's [Form S-8](http://www.sec.gov/Archives/edgar/data/872912/000119312523296807/d500537ds8.htm) filed with the Commission on December 15, 2023 (File No. 333- 276090) and (v) the Registrant's [Form S-8](http://www.sec.gov/Archives/edgar/data/872912/000162828024030414/delcaths-8.htm) filed with the Commission on June 28, 2024 (File No. 333- 280550) (collectively, the "Prior Registration Statements").

This Registration Statement relates to securities of the same class as that to which the Prior Registration Statements relate, and is submitted in accordance with General Instruction E to Form S-8 regarding Registration of Additional Securities. Pursuant to General Instruction E of Form S-8, the contents of the Prior Registration Statements, to the extent relating to the registration of Common Stock issuable under the 2020 EIP, the 2021 ESPP and the Inducement Plan, are incorporated herein by reference and made part of this Registration Statement, except as amended hereby.

**PART II** 

**INFORMATION REQUIRED IN THE REGISTRATION STATEMENT** 

**Item 3 Incorporation of Documents by Reference.** 

The following documents filed with the Commission by the Registrant, pursuant to the Securities Exchange Act of 1934, as amended (the "Exchange Act"), are incorporated herein by reference:

(1) the Registrant's Annual Report on Form 10-K for the fiscal year
ended [December 31, 2024](http://www.sec.gov/Archives/edgar/data/../../../ix?doc=/Archives/edgar/data/0000872912/000162828025010797/dcth-20241231.htm) filed with the Commission on March 6, 2025;

(2) the Registrant's Quarterly Reports on Form 10-Q for the quarterly
periods ended [March 31, 2025](http://www.sec.gov/Archives/edgar/data/../../../ix?doc=/Archives/edgar/data/0000872912/000162828025023507/dcth-20250331.htm) and [June 30, 2025](http://www.sec.gov/Archives/edgar/data/../../../ix?doc=/Archives/edgar/data/0000872912/000162828025038112/dcth-20250630.htm) , filed with the Commission on May 8, 2025 and August 6,
2025, respectively;

------

(3) the Registrant's Current Reports on Form 8-K filed with the
Commission on [January 13, 2025](http://www.sec.gov/Archives/edgar/data/../../../ix?doc=/Archives/edgar/data/0000872912/000119312525005053/d898758d8k.htm) , [March 6, 2025](http://www.sec.gov/Archives/edgar/data/../../../ix?doc=/Archives/edgar/data/0000872912/000162828025010775/dcth-20250306.htm) , [March 21, 2025](http://www.sec.gov/Archives/edgar/data/../../../ix?doc=/Archives/edgar/data/0000872912/000119312525060237/d925045d8k.htm) , [May 8, 2025](http://www.sec.gov/Archives/edgar/data/../../../ix?doc=/Archives/edgar/data/0000872912/000162828025023470/dcth-20250508.htm) , [May 16, 2025](http://www.sec.gov/Archives/edgar/data/../../../ix?doc=/Archives/edgar/data/0000872912/000119312525121700/d19393d8k.htm) , [May 22, 2025](http://www.sec.gov/Archives/edgar/data/../../../ix?doc=/Archives/edgar/data/0000872912/000119312525124538/d946891d8k.htm) , and [August 15, 2025](http://www.sec.gov/Archives/edgar/data/../../../ix?doc=/Archives/edgar/data/872912/000119312525181881/d943145d8k.htm) ;

(4) the information specifically incorporated by reference into the Registrant's Annual Report on Form 10-K for the year ended December 
31, 2024, from the Registrant's Definitive Proxy Statement on Schedule 14A filed with the Commission on [April 1, 2025](http://www.sec.gov/Archives/edgar/data/../../../ix?doc=/Archives/edgar/data/872912/000162828025015761/dcth-20250401.htm) ; and

(5) the description of the Common Stock of the Registrant set forth in the Registrant's registration
statements pursuant to Section 
12 of the Exchange Act, and any amendment or report filed for the purpose of updating such description, including [Exhibit 4.9](http://www.sec.gov/Archives/edgar/data/872912/000162828025010797/ex412-descriptionofsecurit.htm) to the
Registrant's Annual Report on Form 10-K for the year ended December 31, 2024.

All documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act (other than Current Reports furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits furnished on such form that relate to such items), prior to the filing of a post-effective amendment which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference in this Registration Statement and to be a part hereof from the date of filing of such documents.

Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any other subsequently filed document which also is incorporated or deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.

------

**Item 8 Exhibits.** 

The following exhibits are furnished with this Registration Statement:

---

| | |
|:---|:---|
| **Exhibit<br>No.** | **Description of Exhibits** |
| &nbsp;&nbsp;&nbsp;&nbsp;4.1 | [Amended and Restated Certificate of Incorporation of Delcath Systems, Inc. (incorporated by reference to Exhibit 3.1 to the Company's Registration Statement on Form S-1/A filed with the Commission on September 25, 2019)](http://www.sec.gov/Archives/edgar/data/872912/000119312519254834/d794638dex31.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;4.2 | [Amendment to the Amended and Restated Certificate of Incorporation of Delcath Systems, Inc. dated October 17, 2019 (incorporated by reference to Exhibit 3.1 to the Company's Current Report on Form 8-K filed with the Commission on October 23, 2019)](http://www.sec.gov/Archives/edgar/data/872912/000119312519272633/d822396dex31.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;4.3 | [Certificate of Correction to Amendment to the Amended and Restated Certificate of Incorporation of Delcath Systems, Inc. dated October 22, 2019 (incorporated by reference to Exhibit 3.2 to the Company's Current Report on Form 8-K filed with the Commission on October 23, 2019)](http://www.sec.gov/Archives/edgar/data/872912/000119312519272633/d822396dex32.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;4.4 | [Amendment to the Amended and Restated Certificate of Incorporation of Delcath Systems, Inc., effective December 24, 2019 (incorporated by reference to Exhibit 3.1 to the Company's Current Report on Form 8-K filed with the Commission on December 30, 2019)](http://www.sec.gov/Archives/edgar/data/872912/000119312519325987/d821924dex31.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;4.5 | [Certificate of Amendment to the Amended and Restated Certificate of Incorporation of Delcath Systems, Inc. dated November 23, 2020 (incorporated by reference to Exhibit 3.1 to the Company's Current Report on Form 8-K filed with the Commission on November 24, 2020)](http://www.sec.gov/Archives/edgar/data/872912/000119312520302715/d81992dex31.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;4.8 | [Amended and Restated Bylaws, dated August 12, 2025 (incorporated by reference to Exhibit 3.1 to the Company's Current Report on Form 8-K filed with the Commission on August 15, 2025)](http://www.sec.gov/Archives/edgar/data/872912/000119312525181881/d943145dex31.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;4.9 | [Delcath Systems, Inc. 2020 Omnibus Equity Incentive Plan, as amended (incorporated by reference to Exhibit 10.1 to the Company's Quarterly Report on Form 10-Q filed with the Commission on August 6, 2025)](http://www.sec.gov/Archives/edgar/data/872912/000162828025038112/delcathsystemsinc2020omnib.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;4.10 | [Delcath Systems, Inc. 2021 Employee Stock Purchase Plan, as amended (incorporated by reference to Exhibit 10.2 to the Company's Quarterly Report on Form 10-Q filed with the Commission on August 6, 2025)](http://www.sec.gov/Archives/edgar/data/872912/000162828025038112/delcathsystemsinc2021emplo.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;4.11 | [Delcath Systems, Inc. 2023 Inducement Awards Plan, as amended (incorporated by reference to Exhibit 10.3 to the Company's Quarterly Report on Form 10-Q filed with the Commission on August 6, 2025)](http://www.sec.gov/Archives/edgar/data/872912/000162828025038112/delcathsystemsinc2023induc.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;5.1\* | [Opinion of Cooley, LLP](d446811dex51.htm) |
| 23.1\* | [Consent of Cooley, LLP (included in Exhibit 5.1)](d446811dex51.htm) |
| 23.2\* | [Consent of Marcum LLP](d446811dex232.htm) |
| 24.1\* | [Power of Attorney (included on signature page of this Registration Statement)](d446811ds8.htm#sig) |
| 107\* | [Calculation of Filing Fee Table](d446811dexfilingfees.htm) |

---

\* Filed Herewith

------

**SIGNATURES** 

Pursuant to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in Queensbury, State of New York on the 15<sup>th</sup> day of August, 2025.

---

| | |
|:---|:---|
| **DELCATH SYSTEMS, INC.** | **DELCATH SYSTEMS, INC.** |
| By: | /s/ Gerard Michel |
|  | Gerard Michel |
|  | Chief Executive Officer |

---

**POWER OF ATTORNEY** 

KNOW ALL BY THESE PRESENT, that each individual whose signature appears below hereby constitutes and appoints each of Gerard Michel, Sandra Pennell and David Hoffman as such person's true and lawful attorney-in-fact and agent with full power of substitution and resubstitution, for such person in such person's name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement on Form S-8, and to file the same, with all exhibits thereto, and all documents in connection therewith, with the Commission granting unto each said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as such person might or could do in person, hereby ratifying and confirming all that any said attorney-in-fact and agent, or any substitute or substitutes of any of them, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

------

---

| | | |
|:---|:---|:---|
| **SIGNATURE** | **TITLE** | **DATE** |
| /s/ Gerard Michel<br> Gerard Michel | Chief Executive Officer and Director<br> (Principal Executive Officer) | August 15, 2025 |
| /s/ Sandra Pennell<br> Sandra Pennell | Chief Financial Officer<br> (Principal Financial and Accounting Officer) | August 15, 2025 |
| /s/ John R. Sylvester<br> John R. Sylvester | Chairman of the Board | August 15, 2025 |
| /s/ Gilad Aharon<br> Gilad Aharon | Director | August 15, 2025 |
| /s/ Elizabeth Czerepak<br> Elizabeth Czerepak | Director | August 15, 2025 |
| /s/ Steven Salamon<br> Steven Salamon | Director | August 15, 2025 |
| /s/ Bridget Martell<br> Bridget Martell | Director | August 15, 2025 |

---

## Exhibit 5.1

**Exhibit 5.1**![LOGO](g446811g0812131024658.jpg)

Ryan Sansom

+1 617 937 2335

rsansom@cooley.com

August 15, 2025

Delcath Systems, Inc.

566 Queensbury Avenue

Queensbury, New York 12804

**Re: Delcath Systems, Inc. – Registration on Form S-8** 

Ladies and Gentlemen:

We have acted as counsel to Delcath Systems, Inc., a Delaware corporation (the "***Company***"), in connection with the filing by the Company of a registration statement on Form S-8 (the "***Registration Statement***") with the Securities and Exchange Commission (the "***Commission***") covering the offering of up to 2,950,000 shares (the "***Shares***") of the Company's common stock, par value $0.01 per share ("***Common Stock***"), consisting of (i) 2,200,000 shares of Common Stock issuable pursuant to the Company's Omnibus 2020 Equity Incentive Plan, as amended (the "***2020 Plan***"), (ii) 300,000 shares of Common Stock issuable pursuant to the Company's 2021 Employee Stock Purchase Plan, as amended (the "***2021 ESPP***"), and (iii) 450,000 shares of Common Stock issuable pursuant to the Company's 2023 Inducement Plan, as amended (together with the 2020 Plan and 2021 ESPP, the "***Plans***").

In connection with this opinion, we have examined and relied upon (a) the Registration Statement and related prospectuses, (b) the Plans, (c) the Company's certificate of incorporation and bylaws, each as currently in effect and (d) such other records, documents, opinions, certificates, memoranda and other instruments as in our judgment are necessary or appropriate to enable us to render the opinion expressed below. We have assumed the genuineness of all signatures, the authenticity of all documents submitted to us as originals, the conformity to originals of all documents submitted to us as copies, the accuracy, completeness and authenticity of certificates of public officials, and the due authorization, execution and delivery of all documents by all persons other than the Company. As to certain factual matters, we have relied upon a certificate of an officer of the Company and have not independently verified such matters.

Our opinion is expressed only with respect to the General Corporation Law of the State of Delaware. We express no opinion to the extent that any other laws are applicable to the subject matter hereof and express no opinion and provide no assurance as to compliance with any federal or state securities law, rule or regulation.

On the basis of the foregoing, and in reliance thereon, we are of the opinion that the Shares, when issued in accordance with the Plans, the Registration Statement and the related prospectuses, will be validly issued, fully paid and nonassessable (except as to Shares issued pursuant to deferred payment arrangements, which will be fully paid and nonassessable when such deferred payments are made in full).

This opinion is limited to the matters expressly set forth in this letter, and no opinion has been or should be implied, or may be inferred, beyond the matters expressly stated. This opinion speaks only as to law and facts in effect or existing as of the date hereof, and we have no obligation or responsibility to update or supplement this opinion to reflect any facts or circumstances that may hereafter come to our attention or any changes in law that may hereafter occur.

Cooley LLP 500 Boylston Street, 14th Floor, Boston, MA (t) 617 937 2300 (f): 617 937 2400 cooley.com

------

![LOGO](g446811g0812131024658.jpg)

August 15, 2025

Page Two

We consent to the filing of this opinion as an exhibit to the Registration Statement. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act of 1933, as amended, or the rules and regulations of the Commission thereunder.

---

| | |
|:---|:---|
| Very truly yours, | Very truly yours, |
| **COOLEY LLP** | **COOLEY LLP** |
| By: | /s/ Ryan Sansom |
|  | Ryan Sansom |

---

Cooley LLP 500 Boylston Street, 14th Floor, Boston, MA (t) 617 937 2300 (f): 617 937 2400 cooley.com

## Exhibit 23.2

**Exhibit 23.2** 

**<u>CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM</u>**

We consent to the incorporation by reference in this Registration Statement on Form S-8 of our report dated March 6, 2025 with respect to the financial statements of Delcath Systems, Inc. for the year ended December 31, 2024 included in the Annual Report on Form 10-K.

/s/ Marcum LLP

Marcum LLP

New York, NY

August 15, 2025

## Ex-Filing

?xml version='1.0' encoding='ASCII'? EX-FILING FEES

---

| |
|:---|
| **Calculation of Filing Fee Tables**  |
| &nbsp;&nbsp;&nbsp;&nbsp;**S-8**  |
| &nbsp;&nbsp;&nbsp;&nbsp;**DELCATH SYSTEMS, INC.**  |

---

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | **Security Type**  | **Security Class Title**  | **Fee Calculation Rule**  | **Amount Registered**  | **Proposed Maximum Offering Price Per Unit**  | **Maximum Aggregate Offering Price**  | **Fee Rate**  | **Amount of Registration Fee**  |
| 1 | Equity | Omnibus 2020 Equity Incentive Plan Common Stock, par value $0.01 per share | Other | 2200000 | $10.28 | $22616000.00 | 0.0001531 | $3462.51 |
| 2 | Equity | 2021 Employee Stock Purchase Plan Common Stock, par value $0.01 per share | Other | 300000 | $8.74 | $2622000.00 | 0.0001531 | $401.43 |
| 3 | Equity | 2023 Inducement Awards Plan Common Stock, par value $0.01 per share | Other | 450000 | $10.28 | $4626000.00 | 0.0001531 | $708.24 |
| Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: |  | $29864000.00  |  | $4572.18  |
| Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  |  |  |  | $0.00  |
| Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  |  |  |  | $4572.18  |

---

 **Offering Note** <br>

<sup>1</sup> (1) This Registration Statement registers the offer and sale of an aggregate of 2,950,000 shares of common stock of Delcath Systems, Inc. (the "Registrant"), par value $0.01, (the "Common Stock") comprising (i) 2,200,000 shares of Common Stock issuable under the Registrant's 2020 Equity Incentive Plan, as amended (the "2020 EIP"), (ii) 300,000 shares of Common Stock issuable under the Registrant's 2021 Employee Stock Purchase Plan, as amended (the "2021 ESPP"), and (iii) 450,000 shares of Common Stock issuable under the Registrant's 2023 Inducement Awards Plan (the "Inducement Plan"). (2) Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement shall also cover any additional shares of Common Stock which become issuable under the above-named plans by reason of any stock dividend, stock split, recapitalization or any other similar transaction effected without the receipt of consideration which results in an increase in the number of shares of our outstanding Common Stock. (3) Estimated solely for the purposes of calculating the registration fee pursuant to Rule 457(c) and Rule 457(h) under the Securities Act. The offering price per share and the aggregate offering price are based on (a) the average of the high and low prices of the Common Stock as reported on the Nasdaq Global Select Market on August 11, 2025.

<sup>2</sup> (1) This Registration Statement registers the offer and sale of an aggregate of 2,950,000 shares of common stock of Delcath Systems, Inc. (the "Registrant"), par value $0.01, (the "Common Stock") comprising (i) 2,200,000 shares of Common Stock issuable under the Registrant's 2020 Equity Incentive Plan, as amended (the "2020 EIP"), (ii) 300,000 shares of Common Stock issuable under the Registrant's 2021 Employee Stock Purchase Plan, as amended (the "2021 ESPP"), and (iii) 450,000 shares of Common Stock issuable under the Registrant's 2023 Inducement Awards Plan (the "Inducement Plan"). (2) Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement shall also cover any additional shares of Common Stock which become issuable under the above-named plans by reason of any stock dividend, stock split, recapitalization or any other similar transaction effected without the receipt of consideration which results in an increase in the number of shares of our outstanding Common Stock. (4) Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(c) and Rule 457(h) under the Securities Act, and based upon 85% of the average of the high and low prices of the Registrant's Common Stock as reported on the Nasdaq Global Select Market on August 11, 2025. Pursuant to the 2021 ESPP, the purchase price of each share of the Registrant's Common Stock reserved for issuance thereunder will be the lower of 85% of the fair market value on (i) the first day of the offering period or (ii) the exercise date.

<sup>3</sup> (1) This Registration Statement registers the offer and sale of an aggregate of 2,950,000 shares of common stock of Delcath Systems, Inc. (the "Registrant"), par value $0.01, (the "Common Stock") comprising (i) 2,200,000 shares of Common Stock issuable under the Registrant's 2020 Equity Incentive Plan, as amended (the "2020 EIP"), (ii) 300,000 shares of Common Stock issuable under the Registrant's 2021 Employee Stock Purchase Plan, as amended (the "2021 ESPP"), and (iii) 450,000 shares of Common Stock issuable under the Registrant's 2023 Inducement Awards Plan (the "Inducement Plan"). (2) Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement shall also cover any additional shares of Common Stock which become issuable under the above-named plans by reason of any stock dividend, stock split, recapitalization or any other similar transaction effected without the receipt of consideration which results in an increase in the number of shares of our outstanding Common Stock. (3) Estimated solely for the purposes of calculating the registration fee pursuant to Rule 457(c) and Rule 457(h) under the Securities Act. The offering price per share and the aggregate offering price are based on (a) the average of the high and low prices of the Common Stock as reported on the Nasdaq Global Select Market on August 11, 2025.

---

| | |
|:---|:---|
| | |
| **Rule 457(p)** | **Rule 457(p)** |
| Fee Offset Claims | N/A |
| Fee Offset Sources | N/A |

---