# EDGAR Filing Document

**Accession Number:** 0001848319
**File Stem:** 0001072613-26-000257
**Filing Date:** 2026-3
**Character Count:** 31222
**Document Hash:** 97341184779991675d9eff3718f63f10
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001072613-26-000257.hdr.sgml**: 20260311

**ACCESSION NUMBER**: 0001072613-26-000257

**CONFORMED SUBMISSION TYPE**: SCHEDULE 13D/A

**PUBLIC DOCUMENT COUNT**: 3

**FILED AS OF DATE**: 20260311

**DATE AS OF CHANGE**: 20260311

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Design Therapeutics, Inc.
- **CENTRAL INDEX KEY:** 0001807120
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 823929248
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SCHEDULE 13D/A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-92462
- **FILM NUMBER:** 26745427

**BUSINESS ADDRESS:**
- **STREET 1:** 6005 HIDDEN VALLEY ROAD
- **STREET 2:** SUITE 110
- **CITY:** CARLSBAD
- **STATE:** CA
- **ZIP:** 92011
- **BUSINESS PHONE:** 858-293-4900

**MAIL ADDRESS:**
- **STREET 1:** 6005 HIDDEN VALLEY ROAD
- **STREET 2:** SUITE 110
- **CITY:** CARLSBAD
- **STATE:** CA
- **ZIP:** 92011
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** SR One Capital Fund I Aggregator LP
- **CENTRAL INDEX KEY:** 0001848319

**ORGANIZATION NAME:**
- **EIN:** 844496143
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SCHEDULE 13D/A

**BUSINESS ADDRESS:**
- **STREET 1:** 929 MAIN STREET
- **STREET 2:** SUITE 200
- **CITY:** REDWOOD CITY
- **STATE:** CA
- **ZIP:** 94063
- **BUSINESS PHONE:** (410) 800-7503

**MAIL ADDRESS:**
- **STREET 1:** 929 MAIN STREET
- **STREET 2:** SUITE 200
- **CITY:** REDWOOD CITY
- **STATE:** CA
- **ZIP:** 94063

## Ex-1

**<u>EXHIBIT 1</u>**

**AGREEMENT**

Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, the undersigned hereby agree that only one statement containing the information required by Schedule 13D need be filed with respect to the ownership by each of the undersigned of shares of stock of Design Therapeutics, Inc.

EXECUTED this 11<sup>th</sup> day of March, 2026.

---

| | | |
|:---|:---|:---|
| SR ONE CAPITAL FUND I AGGREGATOR, LP | SR ONE CAPITAL FUND I AGGREGATOR, LP | SR ONE CAPITAL FUND I AGGREGATOR, LP |
| By: | SR ONE CAPITAL PARTNERS I, LP | SR ONE CAPITAL PARTNERS I, LP |
|  | By: | SR ONE CAPITAL MANAGEMENT, LLC |
|  |  | By: <u>\*</u> |
|  |  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Simeon George, M.D. |
|  |  | &nbsp;&nbsp;&nbsp;&nbsp; Managing Member |

---

---

| | |
|:---|:---|
| SR ONE CAPITAL PARTNERS I, LP | SR ONE CAPITAL PARTNERS I, LP |
| By: | SR ONE CAPITAL MANAGEMENT, LLC |
|  | By: <u>\*</u> |
|  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Simeon George, M.D. |
|  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Managing Member |

---

---

| |
|:---|
| SR ONE CAPITAL MANAGEMENT, LLC |
| By: <u>\*</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Simeon George, M.D. |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Managing Member |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <u>\*</u> 

Simeon George, M.D.

<u>\*/s/ Sasha Keough</u> 

Sasha Keough

As attorney-in-fact

This Agreement relating to Schedule 13D was executed by Sasha Keough on behalf of the individuals listed above pursuant to a Power of Attorney, a copy of which is attached hereto as Exhibit 2.

## Ex-2

**<u>EXHIBIT 2</u>**

**<u>LIMITED POWER OF ATTORNEY</u>**

Know all by these presents, that the undersigned hereby makes, constitutes and appoints Sasha Keough, Karen Narolewski-Engel, James Macadam, and Alexander M. Bowling, and each of them singly, as each of the undersigned's true and lawful attorneys-in-fact with full power and authority as hereinafter described to:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. execute for and on behalf of each of the undersigned individual and entities (each, a "Filer" and collectively, the "Filers") (i) Forms 3, 4, and 5 (including amendments thereto) in accordance with Section 16(a) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and the rules thereunder, (ii) Form 144 in accordance with Rule 144 under the Securities Act of 1933, as amended (the "Securities Act"), and (iii) Schedules 13D and 13G (including amendments thereto) in accordance with Sections 13(d) and 13(g) of the Exchange Act and the rules thereunder;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. do and perform any and all acts for and on behalf of each of the Filers which may be necessary or desirable to complete and execute any such Form 3, 4, or 5 (including amendments thereto), Form 144, or Schedule 13D or 13G (including amendments thereto) and timely file such form with the United States Securities and Exchange Commission (the "SEC") and any stock exchange or similar authority, including, but not limited to, executing a Form ID or Update Passphrase request for and on behalf of each of the undersigned and filing such applications with the SEC; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3. take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit to, in the best interest of, or legally required by, a Filer, it being understood that the documents executed by such attorney-in-fact on behalf of such Filer pursuant to this Limited Power of Attorney shall be in such form and shall contain such terms and conditions as such attorney-in-fact may approve in such attorney-in-fact's discretion.

Each of the Filers hereby grants to each attorney-in-fact full power and authority to do and perform any and every act and thing whatsoever requisite, necessary, or proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes a Filer might or could do if personally present, with full power of substitution or revocation, hereby ratifying and confirming all the acts such attorney-in-fact, or such attorney-in-fact's substitute or substitutes, shall lawfully do or cause to be done by virtue of this Limited Power of Attorney and the rights and powers herein granted. Each of the Filers acknowledges that each of the foregoing attorneys-in-fact, in serving in such capacity at the request of such Filer, is not assuming any of such Filer's responsibilities to comply with Sections 13 or 16 of the Exchange Act or Rule 144 under the Securities Act.

This Limited Power of Attorney shall remain in full force and effect until a Filer is no longer required to file Forms 3, 4, and 5 (including amendments thereto), Form 144, and Schedules 13D and 13G (including amendments thereto) with respect to such Filer's holdings of and transactions in securities, unless earlier revoked by such Filer in a signed writing delivered to each of the foregoing attorneys-in-fact. In addition, at such time as any attorney-in-fact resigns as attorney-in-fact by the execution of a written resignation delivered to each Filer, without any action on the part of the Filers, this Limited Power of Attorney shall be partially revoked solely with respect to such individual; such individual shall cease to be an attorney-in-fact under this Limited Power of Attorney; and the authority of the other attorneys-in-fact then existing hereunder shall remain in full force and effect.

*[Signature page follows]*

IN WITNESS WHEREOF, each of the undersigned has caused this Limited Power of Attorney to be executed as of this 12th day of December, 2022.

<u>/s/ Simeon George</u> 

Simeon George (Individually)

**SR One Capital Management, LLC,** 

a Delaware limited liability company

By: <u>/s/ Simeon George</u> 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Simeon George, Managing Member

**SR One Capital Fund I Aggregator, LP,**

a Delaware limited partnership

By: SR One Capital Partners I, LP,

a Delaware limited partnership

Its: General Partner

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: General Partner

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Capital Partners I, LP,**

a Delaware limited partnership

By: SR One Capital Management, LLC

a Delaware limited liability company

Its: General Partner

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Capital Fund II Aggregator, LP,**

a Delaware limited partnership

By: SR One Capital Partners II, LP,

a Delaware limited partnership

Its: General Partner

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: General Partner

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Capital Partners II, LP,**

a Delaware limited partnership

By: SR One Capital Management, LLC

a Delaware limited liability company

Its: General Partner

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Capital Opportunities Fund I, LP,**

a Delaware limited partnership

By: SR One Capital Opportunities Partners I, LP,

a Delaware limited partnership

Its: General Partner

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: General Partner

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Capital Opportunities Partners I, LP,**

a Delaware limited partnership

By: SR One Capital Management, LLC

a Delaware limited liability company

Its: General Partner

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest I Manager, LLC,**

a Delaware limited liability company

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest I, LLC,**

a Delaware limited liability company

By: SR One Co-Invest I Manager, LLC,

a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest II Manager, LLC,**

a Delaware limited liability company

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest II, LLC,**

a Delaware limited liability company

By: SR One Co-Invest II Manager, LLC,

a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest III Manager, LLC,**

a Delaware limited liability company

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest III, LLC,**

a Delaware limited liability company

By: SR One Co-Invest III Manager, LLC,

a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest IV Manager, LLC,**

a Delaware limited liability company

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest IV, LLC,**

a Delaware limited liability company

By: SR One Co-Invest IV Manager, LLC,

a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest IV-A, LLC,**

a Delaware limited liability company

By: SR One Co-Invest IV Manager, LLC,

a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest V Manager, LLC,**

a Delaware limited liability company

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest V, LLC,**

a Delaware limited liability company

By: SR One Co-Invest V Manager, LLC,

a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest VI Manager, LLC,**

a Delaware limited liability company

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest VI, LLC,**

a Delaware limited liability company

By: SR One Co-Invest VI Manager, LLC,

a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest VII Manager, LLC,**

a Delaware limited liability company

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest VII, LLC,**

a Delaware limited liability company

By: SR One Co-Invest VII Manager, LLC,

a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest VIII Manager, LLC,**

a Delaware limited liability company

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest VIII, LLC,**

a Delaware limited liability company

By: SR One Co-Invest VIII Manager, LLC,

a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest IX Manager, LLC,**

a Delaware limited liability company

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest IX, LLC,**

a Delaware limited liability company

By: SR One Co-Invest IX Manager, LLC,

a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest X Manager, LLC,**

a Delaware limited liability company

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest X, LLC,**

a Delaware limited liability company

By: SR One Co-Invest X Manager, LLC,

a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest XI Manager, LLC,**

a Delaware limited liability company

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest XI, LLC,**

a Delaware limited liability company

By: SR One Co-Invest XI Manager, LLC,

a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest XII Manager, LLC,**

a Delaware limited liability company

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest XII, LLC,**

a Delaware limited liability company

By: SR One Co-Invest XII Manager, LLC,

a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest XIII Manager, LLC,**

a Delaware limited liability company

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest XIII, LLC,**

a Delaware limited liability company

By: SR One Co-Invest XIII Manager, LLC,

a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest XIV Manager, LLC,**

a Delaware limited liability company

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest XIV, LLC,**

a Delaware limited liability company

By: SR One Co-Invest XIV Manager, LLC,

a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest XV Manager, LLC,**

a Delaware limited liability company

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

**SR One Co-Invest XV, LLC,**

a Delaware limited liability company

By: SR One Co-Invest XV Manager, LLC,

a Delaware limited liability company

Its: Managing Member

By: SR One Capital Management, LLC,

a Delaware limited liability company

Its: Managing Member

By: <u>/s/ Simeon George</u> 

Simeon George, Managing Member

### UNITED STATES SECURITIES AND EXCHANGE COMMISSION
**Washington, D.C. 20549**

## SCHEDULE 13D

### Under the Securities Exchange Act of 1934

**(Amendment No. 2)**

**Design Therapeutics, Inc.**

*(Name of Issuer)*

**Common Stock, $0.0001 par value per share**

*(Title of Class of Securities)*

**25056L103**

*(CUSIP Number)*

**Sasha Keough**<br>c/o SR One Capital Management, LP<br>929 Main Street, Suite 200<br>Redwood City CA 94063<br>(410) 800-7503

*(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)*

**03/09/2026**

*(Date of Event Which Requires Filing of this Statement)*

| **CUSIP No.** | **25056L103** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**SR One Capital Fund I Aggregator, LP** | Name of reporting person<br>**SR One Capital Fund I Aggregator, LP** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**WC** | Source of funds (See Instructions)<br>**WC** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**6526476.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**6526476.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**6526476.00** | Aggregate amount beneficially owned by each reporting person<br>**6526476.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**10.6%** | Percent of class represented by amount in Row (11)<br>**10.6%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**PN** | Type of Reporting Person (See Instructions)<br>**PN** | |

---

| **CUSIP No.** | **25056L103** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**SR One Capital Partners I, LP** | Name of reporting person<br>**SR One Capital Partners I, LP** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**OO** | Source of funds (See Instructions)<br>**OO** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**6526476.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**6526476.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**6526476.00** | Aggregate amount beneficially owned by each reporting person<br>**6526476.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**10.6%** | Percent of class represented by amount in Row (11)<br>**10.6%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**PN** | Type of Reporting Person (See Instructions)<br>**PN** | |

---

| **CUSIP No.** | **25056L103** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**SR One Capital Management, LLC** | Name of reporting person<br>**SR One Capital Management, LLC** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**OO** | Source of funds (See Instructions)<br>**OO** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**6526476.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**6526476.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**6526476.00** | Aggregate amount beneficially owned by each reporting person<br>**6526476.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**10.6%** | Percent of class represented by amount in Row (11)<br>**10.6%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**HC** | Type of Reporting Person (See Instructions)<br>**HC** | |

---

| **CUSIP No.** | **25056L103** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**Simeon George** | Name of reporting person<br>**Simeon George** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**OO** | Source of funds (See Instructions)<br>**OO** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**X1** | Citizenship or place of organization<br>**X1** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**81416.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**6526476.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**81416.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**6526476.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**6607892.00** | Aggregate amount beneficially owned by each reporting person<br>**6607892.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**10.7%** | Percent of class represented by amount in Row (11)<br>**10.7%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**IN** | Type of Reporting Person (See Instructions)<br>**IN** | |

---

**Item 1. Security and Issuer**

**(a) Title of Class of Securities:**
Common Stock, $0.0001 par value per share

**(b) Name of Issuer:**
Design Therapeutics, Inc.

**(c) Address of Issuer's Principal Executive Offices:**
6005 Hidden Valley Road, Suite 110, Carlsbad, CA, 92011

This Amendment No. 2 ("Amendment No. 2") to Schedule 13D amends and supplements the statement on Schedule 13D originally filed on April 9, 2021 (the "Schedule 13D") and Amendment No. 1 thereto filed on December 22, 2022 ("Amendment No. 1") relating to the Common Stock of the Issuer.

Certain terms used but not defined in this Amendment No. 2 have the meanings assigned thereto in the Schedule 13D (and Amendment No. 1 thereto). Except as specifically provided herein, this Amendment No. 2 does not modify any of the information previously reported on the Schedule 13D (and Amendment No. 1 thereto).

This Amendment No. 2 is being filed to report that the beneficial ownership of Common Stock by the Reporting Persons (as defined below) has decreased by more than 1% as a result of an increase in the number of Common Stock outstanding.

**Item 4. Purpose of Transaction**

Not applicable.

**Item 5. Interest in Securities of the Issuer**

**(a)**
The percentage of outstanding shares of Common Stock which may be deemed to be beneficially owned by each Reporting Person is set forth on Line 13 of such Reporting Person's cover sheet. Such percentage was calculated based on 61,672,279 shares of Common Stock reported by the Issuer to be outstanding as of March 2, 2026, on the Issuer's Form 10-K filed with the Securities Exchange Commission on March 9, 2026.

**(b)**
Regarding the number of shares as to which such person has:

(i) sole power to vote or to direct the vote: See line 7 of cover sheets

(ii) shared power to vote or to direct the vote: See line 8 of cover sheets

(iii) sole power to dispose or to direct the disposition: See line 9 of cover sheets

(iv) shared power to dispose or to direct the disposition: See line 10 of cover sheets.

**(c)**
None of the Reporting Persons has effected any transaction in shares of Common Stock during the last 60 days.

**Item 6. Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer.**

Not applicable.

### SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** SR One Capital Fund I Aggregator, LP

**Signature:** /s/ Sasha Keough

**Name/Title:** Sasha Keough, as attorney-in-fact for Simeon George, M.D., Managing Member

**Date:** 03/11/2026

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** SR One Capital Partners I, LP

**Signature:** /s/ Sasha Keough

**Name/Title:** Sasha Keough, as attorney-in-fact for Simeon George, M.D., Managing Member

**Date:** 03/11/2026

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** SR One Capital Management, LLC

**Signature:** /s/ Sasha Keough

**Name/Title:** Sasha Keough, as attorney-in-fact for Simeon George, M.D., Managing Member

**Date:** 03/11/2026

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** Simeon George

**Signature:** /s/ Sasha Keough

**Name/Title:** Sasha Keough, as attorney-in-fact for Simeon George, M.D., Managing Member

**Date:** 03/11/2026