# EDGAR Filing Document

**Accession Number:** 0001569248
**File Stem:** 0001104659-26-048551
**Filing Date:** 2026-4
**Character Count:** 8189
**Document Hash:** 2aad1f42bdae98e4ed45ee43af65d7b3
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-26-048551.hdr.sgml**: 20260424

**ACCESSION NUMBER**: 0001104659-26-048551

**CONFORMED SUBMISSION TYPE**: 4

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20260423

**FILED AS OF DATE**: 20260424

**DATE AS OF CHANGE**: 20260424

**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Burow Kristina
- **CENTRAL INDEX KEY:** 0001569248

**ORGANIZATION NAME:**

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-38501
- **FILM NUMBER:** 26893542

**MAIL ADDRESS:**
- **STREET 1:** 8755 W. HIGGINS ROAD
- **STREET 2:** SUITE 1025
- **CITY:** CHICAGO
- **STATE:** IL
- **ZIP:** 60631
**ISSUER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Scholar Rock Holding Corp
- **CENTRAL INDEX KEY:** 0001727196
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 823750435
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**BUSINESS ADDRESS:**
- **STREET 1:** 301 BINNEY STREET
- **STREET 2:** 3RD FLOOR
- **CITY:** CAMBRIDGE
- **STATE:** MA
- **ZIP:** 02142
- **BUSINESS PHONE:** 857-259-3860

**MAIL ADDRESS:**
- **STREET 1:** 301 BINNEY STREET
- **STREET 2:** 3RD FLOOR
- **CITY:** CAMBRIDGE
- **STATE:** MA
- **ZIP:** 02142

### UNITED STATES SECURITIES AND EXCHANGE COMMISSION
**Washington, D.C. 20549**

## FORM 4

### STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

[ ] Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Burow Kristina<br><sub>(Last) (First) (Middle)</sub><br>301 BINNEY STREET<br><sub>(Street)</sub><br>CAMBRIDGE, MA 02142<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2026-04-23 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[X] Director [ ] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>Scholar Rock Holding Corp [ SRRK ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[X] Form filed by One Reporting Person<br>[ ] Form filed by More than One Reporting Person |

---

## Table I - Non-Derivative Securities

---

|  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1. Title of Security | 2. Transaction Date | 2A. Deemed Execution Date | 3. Transaction Code (V) | 3. Transaction Code (V) | 4. Securities Acquired (A) or Disposed of (D) | 4. Securities Acquired (A) or Disposed of (D) | 4. Securities Acquired (A) or Disposed of (D) | 5. Amount of Securities Beneficially Owned | 6. Ownership Form | 7. Nature of Indirect Beneficial Ownership |
| 1. Title of Security | 2. Transaction Date | 2A. Deemed Execution Date | Code | V | Amount | (A) or (D) | Price | 5. Amount of Securities Beneficially Owned | 6. Ownership Form | 7. Nature of Indirect Beneficial Ownership |
| Common Stock | 2026-04-23 |  | M |  | 7800 | A | $26.78 | 28871<sup>(1)</sup> | D |  |
| Common Stock | 2026-04-23 |  | M |  | 28000 | A | $4.75 | 56871<sup>(2)</sup> | D |  |
| Common Stock | 2026-04-23 |  | M |  | 36000 | A | $9.11 | 92871<sup>(3)</sup> | D |  |
| Common Stock | 2026-04-23 |  | M |  | 18000 | A | $8.36 | 110871<sup>(4)</sup> | D |  |
| Common Stock |  |  |  |  |  |  |  | 2345711 | I | See footnote<sup>(5)(6)</sup> |

---

## Table II - Derivative Securities

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1. Title of Derivative Security | 2. Conversion or Exercise Price | 3. Transaction Date | 3A. Deemed Execution Date | 4. Transaction Code (V) | 4. Transaction Code (V) | 5. Number of Derivative Securities Acquired (A) or Disposed of (D) | 5. Number of Derivative Securities Acquired (A) or Disposed of (D) | 6. Date Exercisable and Expiration Date | 6. Date Exercisable and Expiration Date | 7. Title and Amount of Underlying Securities | 7. Title and Amount of Underlying Securities | 8. Price of Derivative Security | 9. Number of Derivative Securities Beneficially Owned | 10. Ownership Form | 11. Nature of Indirect Beneficial Ownership |
| 1. Title of Derivative Security | 2. Conversion or Exercise Price | 3. Transaction Date | 3A. Deemed Execution Date | Code | V | (A) | (D) | Date Exercisable | Expiration Date | Title | Amount or Number of Shares | 8. Price of Derivative Security | 9. Number of Derivative Securities Beneficially Owned | 10. Ownership Form | 11. Nature of Indirect Beneficial Ownership |
| Stock Option (Right to Buy) | $26.78 | 2026-04-23 |  | M |  |  | 7800 | <sup>(7)</sup> | 2031-05-27 | Common Stock | 7800 | $0 | 0 | D |  |
| Stock Option (Right to Buy) | $4.75 | 2026-04-23 |  | M |  |  | 28000 | <sup>(8)</sup> | 2032-05-26 | Common Stock | 28000 | $0 | 0 | D |  |
| Stock Option (Right to Buy) | $9.11 | 2026-04-23 |  | M |  |  | 36000 | <sup>(9)</sup> | 2033-06-21 | Common Stock | 36000 | $0 | 0 | D |  |
| Stock Option (Right to Buy) | $8.36 | 2026-04-23 |  | M |  |  | 18000 | <sup>(10)</sup> | 2034-06-27 | Common Stock | 18000 | $0 | 0 | D |  |

---

### Footnotes:

(1) Consists of 21,239 shares of common stock and 7,632 RSUs.

(2) Consists of 49,239 shares of common stock and 7,632 RSUs..

(3) Consists of 85,239 shares of common stock and 7,632 RSUs.

(4) Consists of 103,239 shares of common stock and 7,632 RSUs.

(5) The shares are held by ARCH Venture Fund VIII, L.P. ("ARCH VIII"). ARCH Venture Partners VIII, L.P. ("GPLP"), as the sole general partner of ARCH VIII, may be deemed to beneficially own the shares held by ARCH VIII. ARCH Venture Partners VIII, LLC ("GPLLC"), as the sole general partner of GPLP, may be deemed to beneficially own the shares held by GPLP. The GPLP and GPLLC disclaim beneficial ownership of such securities, except to the extent of any pecuniary interest therein.

(6) The managing directors of the GPLLC are Keith L. Crandell, Clinton Bybee and Robert Nelsen, and they may be deemed to beneficially own the shares held by ARCH VIII. Messrs. Crandell, Bybee and Nelsen disclaim beneficial ownership of such shares, except to the extent of any pecuniary interest therein. The Reporting Person is a managing director of the GPLP. The Reporting Person owns an interest in the GPLP but does not have voting or investment control over the shares held by ARCH VIII. The Reporting Person disclaims ownership of such shares, except to the extent of her pecuniary interest therein.

(7) This stock option vested on May 26, 2022. No shares remain unvested under this stock option.

(8) This stock option vested on May 26, 2023. No shares remain unvested under this stock option.

(9) This stock option vested on June 21, 2024. No shares remain unvested under this stock option.

(10) This stock option vested on May 22, 2025. No shares remain unvested under this stock option.

**Signature:** /s/ Junlin Ho, Attorney-in-Fact for Kristina Burow  
**Date:** 2026-04-24

### Remarks:

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

**Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.**