# EDGAR Filing Document

**Accession Number:** 0001709401
**File Stem:** 0001104659-23-025604
**Filing Date:** 2023-2
**Character Count:** 8162
**Document Hash:** 1cafdb35c1507fefce4123b0afdda99f
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-23-025604.hdr.sgml**: 20230227

**ACCESSION NUMBER**: 0001104659-23-025604

**CONFORMED SUBMISSION TYPE**: S-8 POS

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20230227

**DATE AS OF CHANGE**: 20230227

**EFFECTIVENESS DATE**: 20230227

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Rubius Therapeutics, Inc.
- **CENTRAL INDEX KEY:** 0001709401
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **IRS NUMBER:** 042688109
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8 POS
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-255942
- **FILM NUMBER:** 23669992

**BUSINESS ADDRESS:**
- **STREET 1:** C/O VERDOLINO & LOWEY, P.C.
- **STREET 2:** 124 WASHINGTON STREET, SUITE 101
- **CITY:** FOXBORO
- **STATE:** MA
- **ZIP:** 02035
- **BUSINESS PHONE:** 617-679-9600

**MAIL ADDRESS:**
- **STREET 1:** C/O VERDOLINO & LOWEY, P.C.
- **STREET 2:** 124 WASHINGTON STREET, SUITE 101
- **CITY:** FOXBORO
- **STATE:** MA
- **ZIP:** 02035

**As filed with the Securities and Exchange Commission on February 27, 2023**

**Registration No. 333-264814**

**Registration No. 333-255942**

**Registration No. 333-237103**

**Registration No. 333-231478**

**Registration No. 333-226226**

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, DC 20549**

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-264814**

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-255942**

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-237103**

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-231478**

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-226226**

**REGISTRATION STATEMENT**

***UNDER***

***THE SECURITIES ACT OF 1933***

**RUBIUS THERAPEUTICS, INC.**

**(Exact name of registrant as specified in its charter)**

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| | |
|:---|:---|
| **Delaware** | **46-2688109** |
| **(State or other jurisdiction of incorporation or organization)** | **(I.R.S. Employer Identification No.)** |
| **c/o Verdolino & Lowey, P.C.**<br> **124 Washington Street, Suite 101**<br> **Foxborough, Massachusetts**  | **02035** |
| **(Address of Principal Executive Offices)** | **(Zip Code)** |

---

**Rubius Therapeutics, Inc. Amended and Restated 2014 Stock Incentive Plan**

**Rubius Therapeutics, Inc. 2018 Stock Option and Incentive Plan**

**Rubius Therapeutics, Inc. 2018 Employee Stock Purchase Plan**

**(Full title of the plans)**

**Dannielle Appelhans**

**Chief Executive Officer**

**Rubius Therapeutics, Inc.**

**c/o Verdolino & Lowey, P.C.**

**124 Washington Street, Suite 101**

**Foxborough, MA 02035**

**(508) 543-1720**

**(Name and address of agent for service and telephone number, including area code, of agent for service)**

*Copies to:*

**Jacqueline Mercier, Esq.**

**Yasin Akbari, Esq.**

**Goodwin Procter LLP**

**100 Northern Avenue**

**Boston, Massachusetts 02210**

**(617) 570-1762**

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act (Check one):

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| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ¨ | Accelerated filer | ¨ |
| Non-accelerated filer | ¨ (Do not check if a smaller reporting company) | Smaller reporting company | x |
|  |  | Emerging growth company | ¨ |

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If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ¨

**DEREGISTRATION OF SECURITIES**

This Post-Effective Amendment No. 1 ("<u>Post-Effective Amendment No. 1</u>"), filed by Rubius Therapeutics, Inc., a Delaware corporation (the "<u>Company</u>"), removes from registration all shares of the Company's common stock, par value $0.001 per share (the "<u>Common Stock</u>") registered under the following Registration Statements on Form S-8 filed by the Company (each a "<u>Registration Statement</u>," and collectively, the "<u>Registration Statements</u>") with the U.S. Securities and Exchange Commission (the "<u>Commission</u>"), pertaining to the registration of shares of Common Stock offered under certain employee benefit and equity plans and agreements:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration Statement on Form S-8 (No. 333-264814), filed with the Commission on May 10, 2022, pertaining to the registration of 3,152,231 shares of Common Stock of the Company, relating to the Company's 2018 Stock Option and Incentive Plan (the " <u>2018 Plan</u> ").

• Registration Statement on Form S-8 (No. 333-255942), filed with the Commission on May 10, 2021, pertaining to the registration of 2,431,609 shares of Common Stock of the Company, relating to the 2018 Plan.

• Registration Statement on Form S-8 (No. 333-237103), filed with the Commission on March 12, 2020, pertaining to the registration of 3,200,649 shares of Common Stock of the Company, relating to the 2018 Plan.

• Registration Statement on Form S-8 (No. 333-231478), filed with the Commission on May 15, 2019, pertaining to the registration of 3,169,393 shares of Common Stock of the Company, relating to the Company's 2018 Plan and 2018 Employee Stock Purchase Plan (the " <u>2018 ESPP</u> ").

• Registration Statement on Form S-8 (No. 333-226226), filed with the Commission on July 18, 2018, pertaining to the registration of 18,621,525 shares of Common Stock of the Company, relating to the 2018 Plan, 2018 ESPP, and the Company's Amended and Restated 2014 Stock Incentive Plan.

As previously disclosed in a Form 8-K filed with the Commission on February 22, 2023, the board of directors of the Company (the "<u>Board</u>") approved a plan of liquidation and dissolution of the Company (the "<u>Plan of Dissolution</u>"), subject to the approval of the Company's stockholders. As a result of the proposed dissolution, the Company has terminated all offerings of its securities pursuant to its existing registration statements, including the Registration Statements. The Company hereby terminates the effectiveness of the Registration Statements and removes and withdraws from registration all securities of the Company registered under the Registration Statements that remain unsold as of the date hereof.

**SIGNATURES**

Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing this Post-Effective Amendment No. 1 to the Registration Statements on Form S-8 and has duly caused this Post-Effective Amendment No. 1 to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Foxborough in the Commonwealth of Massachusetts, on February 27, 2023.

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| | | |
|:---|:---|:---|
| **RUBIUS THERAPEUTICS, INC.** | **RUBIUS THERAPEUTICS, INC.** | **RUBIUS THERAPEUTICS, INC.** |
| By: | /s/ Dannielle Appelhans | /s/ Dannielle Appelhans |
|  | Name: | Dannielle Appelhans |
|  | Title: | Chief Executive Officer<br> (Principal Executive Officer) |

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Pursuant to the requirements of the Securities Act of 1933, this Post-Effective Amendment No. 1 to the Registration Statements on Form S-8 has been signed by the following person in the capacity and on the date indicated.

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| | | |
|:---|:---|:---|
| **Signatures** | **Capacity** | **Date** |
| <br> /s/ Pablo Cagnoni<br> Pablo Cagnoni | <br> Director | <br> February 27, 2023 |
| <br> \*<br> Catherine Sohn | <br> Director | <br> February 27, 2023 |
| <br> \*<br> Jonathan R. Symonds | <br> Director | <br> February 27, 2023 |

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| | |
|:---|:---|
| \* By: | /s/ Pablo Cagnoni |
|  | Pablo Cagnoni |
|  | Attorney-in-Fact |

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