# EDGAR Filing Document

**Accession Number:** 0001711279
**File Stem:** 0001711279-23-000005
**Filing Date:** 2023-2
**Character Count:** 27131
**Document Hash:** 920346f157c798cdaff820ce52b35eda
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001711279-23-000005.hdr.sgml**: 20230202

**ACCESSION NUMBER**: 0001711279-23-000005

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 4

**FILED AS OF DATE**: 20230202

**DATE AS OF CHANGE**: 20230202

**EFFECTIVENESS DATE**: 20230202

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Krystal Biotech, Inc.
- **CENTRAL INDEX KEY:** 0001711279
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **IRS NUMBER:** 821080209
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-269539
- **FILM NUMBER:** 23582015

**BUSINESS ADDRESS:**
- **STREET 1:** 2100 WHARTON STREET
- **STREET 2:** SUITE 701
- **CITY:** PITTSBURGH
- **STATE:** PA
- **ZIP:** 15203
- **BUSINESS PHONE:** (412) 586-5830

**MAIL ADDRESS:**
- **STREET 1:** 2100 WHARTON STREET
- **STREET 2:** SUITE 701
- **CITY:** PITTSBURGH
- **STATE:** PA
- **ZIP:** 15203

**As filed with the Securities and Exchange Commission on February 2, 2023**

**Registration No. 333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

<u>&nbsp;&nbsp;&nbsp;&nbsp;</u>

**FORM S-8**

**REGISTRATION STATEMENT**

***UNDER THE***

***SECURITIES ACT OF 1933***

<u>&nbsp;&nbsp;&nbsp;&nbsp;</u>

**KRYSTAL BIOTECH, INC.**

**(Exact name of registrant as specified in its charter)**

<u>&nbsp;&nbsp;&nbsp;&nbsp;</u>

---

| | |
|:---|:---|
| **Delaware**<br>**(State or other jurisdiction of**<br>**incorporation or organization)** | **81-0930882**<br>**(IRS Employer**<br>**Identification Number)** |
| **2100 Wharton Street, Suite 701**<br>**Pittsburgh, Pennsylvania**<br>**(Address of principal executive offices)** | **15203**<br>**(Zip code)** |

---

**2017 IPO Stock Incentive Plan**

**(Full title of the plan)**

**Krish S. Krishnan**

**Chief Executive Officer**

**Krystal Biotech, Inc.**

**2100 Wharton Street, Suite 701**

**Pittsburgh, Pennsylvania 15203**

**(Name and address of agent for service)**

**(412) 586-5830**

**(Telephone number, including area code, of agent for service)**

***Copies to:***

**John Hensley, Esq.**

**Morrison & Foerster LLP**

**701 Brazos Street**

**Suite 1100**

**Austin, TX, 78701**

**(737) 309-0700**

<u>&nbsp;&nbsp;&nbsp;&nbsp;</u>

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | | |
|:---|:---|:---|:---|:---|
| Large accelerated filer | ☒ | | Accelerated filer | ☐ |
| Non-accelerated filer | ☐ | (Do not check if a smaller reporting company) | Smaller reporting company | ☐ |
| | | | Emerging growth company | ☐ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

------

**EXPLANATORY NOTE**

This Registration Statement on Form S-8 (the "Registration Statement") is being filed by Krystal Biotech, Inc. (the "Registrant") with the Securities and Exchange Commission (the "Commission") for the purpose of registering 1,027,885 shares of the Registrant's common stock, par value $0.00001 per share (the "Common Stock"), issuable pursuant to the Registrant's 2017 IPO Stock Incentive Plan (the "Plan").

The Plan reserved a total of 900,000 shares of Common Stock for issuance when it was originally adopted and approved by the Registrant's stockholders on September 5, 2017. The "evergreen" provision of the Plan provides that the maximum amount of shares of Common Stock authorized under the Plan shall be increased each calendar year by a number equal to four percent (4%) of the number of shares outstanding as of the last day of the immediately preceding calendar year. The Registrant initially registered 900,000 shares of Common Stock reserved for issuance under the Plan on a registration statement on Form S-8 filed with the Commission on September 22, 2017. The Registrant then registered (i) 2,472,188 additional shares of Common Stock on Form S-8 filed with the Commission on January 22, 2021 and (ii) 1,004,367 additional shares of Common Stock on Form S-8 filed with the Commission on February 17, 2022 (together with the initial registration statement, the "Prior Registration Statements") that were reserved for issuance pursuant to the "evergreen" provision of the Plan. The Registrant is now registering an additional 1,027,885 shares of Common Stock that have been reserved for issuance pursuant to the "evergreen" provision of the Plan with the filing of this Registration Statement.

In accordance with General Instruction E to Form S-8, the contents of the Prior Registration Statements are hereby incorporated by reference.

------

**PART I**

**INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS**

The documents containing the information specified in this Part I will be sent or given to the persons participating in the Plan, as specified by Rule 428(b)(1) under the Securities Act. In accordance with the instructions to Part I of Form S-8, such documents need not be filed with the Commission either as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424 promulgated under the Securities Act. These documents and the documents incorporated by reference in this Registration Statement pursuant to Item 3 of Part II of this registration statement, taken together, constitute a prospectus that meets the requirements of Section 10(a) of the Securities Act.

**PART II**

**INFORMATION REQUIRED IN THE REGISTRATION STATEMENT**

**Item 3.&nbsp;&nbsp;&nbsp;&nbsp;Incorporation of Documents by Reference.**

The following documents, which the Registrant has previously filed with the Commission, are hereby incorporated by reference into this Registration Statement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.&nbsp;&nbsp;&nbsp;&nbsp;The Registrant's Annual Report on <u>[Form 10-K](http://www.sec.gov/Archives/edgar/data/1711279/000156459020009550/krys-10k_20191231.htm)</u> for the fiscal year ended December 31, 2021 filed with the Commission on February 28, 2022;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.&nbsp;&nbsp;&nbsp;&nbsp;The Registrant's Quarterly Report on Form 10-Q for the fiscal quarter ended <u>March 31, 2022</u> filed with the Commission on May 9, 2022; the Registrant's Quarterly Report on Form 10-Q for the fiscal quarter ended <u>June 30, 2022</u> filed with the Commission on August 8, 2022; and the Registrant's Quarterly Report on Form 10-Q for the fiscal quarter ended <u>September 30, 2022</u> filed with the Commission on November 7, 2022;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.&nbsp;&nbsp;&nbsp;&nbsp;The Registrant's Current Reports on Form 8-K filed with the Commission on January 18, 2022, February 28, 2022, May 23, 2022, May 26, 2022, and August 18, 2022;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.&nbsp;&nbsp;&nbsp;&nbsp;The sections of the Registrant's <u>[Definitive Proxy Statement](http://www.sec.gov/Archives/edgar/data/1711279/000156459020016447/krys-def14a_20200529.htm)</u> on Schedule 14A filed with the SEC on April 7, 2022 that are incorporated by reference to the Registrant's Annual Report on <u>[Form 10-K](http://www.sec.gov/Archives/edgar/data/1711279/000156459020009550/krys-10k_20191231.htm)</u> for the fiscal year ended December 31, 2021; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.&nbsp;&nbsp;&nbsp;&nbsp;The description of the Registrant's common stock contained in the Registrant's registration statement on <u>[Form 8-A](http://www.sec.gov/Archives/edgar/data/1711279/000119312517288012/d450974d8a12b.htm)</u> (File No. 001-38210) filed with the Commission on September 19, 2017, pursuant to Section 12(b) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), including any amendment or report filed for the purpose of updating such description.

All documents and reports subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective amendment which indicates that all securities offered have been sold or which deregisters all securities remaining unsold, shall be deemed to be incorporated by reference in this registration statement and to be part hereof from the date of filing of such documents or reports; *provided, however*, that documents or information deemed to have been furnished and not filed in accordance with the rules of the Commission shall not be deemed incorporated by reference into this Registration Statement. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.

**Item 4.&nbsp;&nbsp;&nbsp;&nbsp;Description of Securities.**

Not applicable.

**Item 5.&nbsp;&nbsp;&nbsp;&nbsp;Interests of Named Experts and Counsel.**

Not applicable.

**Item 6.&nbsp;&nbsp;&nbsp;&nbsp;Indemnification of Directors and Officers.**

The Registrant's amended and restated certificate of incorporation contains provisions that eliminate, to the maximum extent permitted by the General Corporation Law of the State of Delaware, the personal liability of the Registrant's directors for monetary damages for breach of their fiduciary duties as directors. The Registrant's amended and restated certificate of incorporation and bylaws provides that the Registrant must indemnify its directors and executive officers and may indemnify its employees and other agents to the fullest extent permitted by the General Corporation Law of the State of Delaware; *provided, however*, that the Registrant is not required to indemnify any director or officer in connection with any proceeding (or part thereof) initiated by such person, unless the proceeding was authorized by the Registrant's board of directors.

In addition, the Registrant has entered into indemnification agreements with its directors and executive officers, and intends to enter into indemnification agreements with any new directors and executive officers in the future.

Sections 145 and 102(b)(7) of the General Corporation Law of the State of Delaware provide that a corporation may indemnify any person made a party to an action by reason of the fact that he or she was a director, executive officer, employee or agent of the corporation or is or was serving at the request of a corporation against expenses (including attorneys' fees), judgments, fines and

------

amounts paid in settlement actually and reasonably incurred by him or her in connection with such action if he or she acted in good faith and in a manner he or she reasonably believed to be in, or not opposed to, the best interests of the corporation and, with respect to any criminal action or proceeding, had no reasonable cause to believe his or her conduct was unlawful, except that, in the case of an action by or in right of the corporation, no indemnification may generally be made in respect of any claim as to which such person is adjudged to be liable to the corporation.

The Registrant has purchased and intends to maintain insurance on behalf of each and any person who is or was a director or officer of the Registrant against any loss arising from any claim asserted against him or her and incurred by him or her in any such capacity, subject to certain exclusions.

**Item 7.&nbsp;&nbsp;&nbsp;&nbsp;Exemption from Registration Claimed.**

Not applicable.

------

**Item 8.&nbsp;&nbsp;&nbsp;&nbsp;Exhibits.**

---

| | |
|:---|:---|
| **Exhibit<br>No.** | **Description** |
| 4.1 | <u>[Form of Common Stock Certificate (incorporated by reference to Exhibit 4.1 to the Registrant's Registration Statement on Form S-1/A filed on September 14, 2017 (File No. 333-220085)).](http://www.sec.gov/Archives/edgar/data/1711279/000119312517285053/d403532dex41.htm)</u> |
| 5.1 | <u>[Opinion of Morrison & Foerster LLP.](exhibit51.htm)</u> |
| 10.1 | <u>[Krystal Biotech, Inc. 2017 IPO Stock Incentive Plan (incorporated by reference to Exhibit 10.7 to the Registrant's Registration Statement on Form S-1/A filed on September 14, 2017 (File No. 333-220085)).](http://www.sec.gov/Archives/edgar/data/1711279/000119312517285053/d403532dex107.htm)</u> |
| 10.2 | <u>[Form Krystal Biotech, Inc. 2017 IPO Stock Incentive Plan Notice of Stock Option Award (incorporated by reference to Exhibit 10.9 to the Registrant's Registration Statement on Form S-1/A filed on September 14, 2017 (File No. 333-220085)).](https://www.sec.gov/Archives/edgar/data/1711279/000119312517285053/d403532dex109.htm)</u> |
| 23.1 | <u>[Consent of Mayer Hoffman McCann P.C., independent public accounting firm.](exhibit231.htm)</u> |
| 23.2 | <u>[Consent of Morrison & Foerster LLP (included in Exhibit 5.1).](exhibit51.htm)</u> |
| 24.1 | <u>[Power of Attorney (included on signature page).](#ic8e622194fe44dc888acd1a183e1d6d6_208)</u> |
| 107 | <u>[Filing Fee Table](exhibit107filingfeetablekr.htm)</u> |

---

------

**Item 9.&nbsp;&nbsp;&nbsp;&nbsp;Undertakings.**

(a) The undersigned Registrant hereby undertakes:

(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:

(i) To include any prospectus required by Section 10(a)(3) of the Securities Act of 1933;

(ii) To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective registration statement; and

(iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement;

*provided, however*, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in this Registration Statement.

(2) That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial *bona fide* offering thereof.

(3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

(b) The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act of 1933, each filing of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial *bona fide* offering thereof.

(c) Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act of 1933 and will be governed by the final adjudication of such issue.

------

**SIGNATURES**

Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Pittsburgh, Commonwealth of Pennsylvania, on the 2<sup>nd</sup> day of February, 2023.

---

| | |
|:---|:---|
| **Krystal Biotech, Inc.** | **Krystal Biotech, Inc.** |
| By: | /s/ Krish S. Krishnan |
|  | Krish S. Krishnan |
|  | President and Chief Executive Officer |

---

**POWER OF ATTORNEY**

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Krish S. Krishnan as his or her true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments to this Registration Statement (including post-effective amendments to the registration statement), and to file the same, with all exhibits thereto, and any other documents in connection therewith, granting unto said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

---

| | | |
|:---|:---|:---|
| **Name** | **Capacity** | **Date** |
| /s/ Krish S. Krishnan | President and Chief Executive Officer and Chairman<br>(Principal Executive Officer) | February 2, 2023 |
| Krish S. Krishnan | President and Chief Executive Officer and Chairman<br>(Principal Executive Officer) | February 2, 2023 |
| /s/ Kathryn A. Romano | Chief Accounting Officer<br>(Principal Financial Officer) | February 2, 2023 |
| Kathryn A. Romano | Chief Accounting Officer<br>(Principal Financial Officer) | February 2, 2023 |
| /s/ Suma M. Krishnan | President, R&D and Director | February 2, 2023 |
| Suma M. Krishnan | President, R&D and Director | February 2, 2023 |
| /s/ Kirti Ganorkar | Director | February 2, 2023 |
| Kirti Ganorkar | Director | February 2, 2023 |
| /s/ Daniel S. Janney | Director | February 2, 2023 |
| Daniel S. Janney | Director | February 2, 2023 |
| /s/ Dino A. Rossi | Director | February 2, 2023 |
| Dino A. Rossi | Director | February 2, 2023 |
| /s/ Julian Gangolli | Director | February 2, 2023 |
| Julian Gangolli | Director | February 2, 2023 |
| /s/ E. Rand Sutherland | Director | February 2, 2023 |
| E. Rand Sutherland | Director | February 2, 2023 |
| /s/ Christopher Mason | Director | February 2, 2023 |
| Christopher Mason | Director | February 2, 2023 |

---

## Ex-Filing

**Exhibit 107**

**Calculation of Filing Fee Tables**

**Form S-8**

(Form Type)

**Krystal Biotech, Inc.**

(Exact Name of Registrant as Specified in its Charter)

**Table 1: Newly Registered Securities**

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | **Security Type** | **Security Class Title** | **Fee Calculation Rule** | **Amount Registered (1)** | **Proposed Maximum Offering Price Per Unit** | **Maximum Aggregate Offering Price** | **Fee Rate** | **Amount of Registration Fee** |
| Fees to Be Paid | Equity | Common Stock, $0.00001 par value per share | 457(c) and 457 (h) | 1027885(2) | $82.04(3) | $84327685.40 | 0.0001102 | $9292.91 |
| Total Offering Amounts | Total Offering Amounts | Total Offering Amounts | Total Offering Amounts | Total Offering Amounts |  | $84327685.40 |  | $9292.91 |
| Total Fee Offsets | Total Fee Offsets | Total Fee Offsets | Total Fee Offsets | Total Fee Offsets |  |  |  | **—** |
| Net Fee Due | Net Fee Due | Net Fee Due | Net Fee Due | Net Fee Due |  |  |  | $9292.91 |

---

(1)&nbsp;&nbsp;&nbsp;&nbsp;Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement shall also cover any additional shares of common stock that become issuable under Krystal Biotech, Inc. (the "Registrant")'s 2017 IPO Stock Incentive Plan (the "Plan"), by reason of certain corporate transactions or events, including any share dividend, share split, recapitalization or certain other transactions that result in an increase in the number of the outstanding shares of the common stock.

(2)&nbsp;&nbsp;&nbsp;&nbsp;Represents shares of common stock that were added to the shares reserved for future issuance under the Plan pursuant to the "evergreen" provision of the Plan, which was originally approved by the Registrant's stockholders on September 5, 2017.

(3)&nbsp;&nbsp;&nbsp;&nbsp;Estimated in accordance with Rules 457(c) and (h) under the Securities Act solely for the purpose of calculating the registration fee on the basis of $82.04 per share, which represents the average of the high and low sales prices of the Registrant's common stock as reported on the Nasdaq Capital Market on February 1, 2023.

## Exhibit 5.1

**EXHIBIT 5.1** 

**OPINION OF MORRISON & FOERSTER, LLP**

February 2, 2023

Krystal Biotech, Inc.

2100 Wharton Street, Suite 701

Pittsburgh, Pennsylvania 15203

Re: <u>Registration Statement on Form S-8</u> 

Ladies and Gentlemen:

We are acting as counsel to Krystal Biotech, Inc., a Delaware corporation (the "<u>Company</u>"), in connection with its registration statement on Form S-8 (the "<u>Registration Statement</u>"), filed with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the "<u>Securities Act</u>"), relating to an aggregate of up to 1,027,885 shares (the "<u>Shares</u>") of the Company's common stock, $0.00001 par value per share, reserved for issuance pursuant to the Company's 2017 IPO Stock Incentive Plan (the "<u>Plan</u>").

As counsel for the Company, we have examined originals or copies, certified or otherwise identified to our satisfaction, of such documents, corporate records, certificates of public officials and other instruments as we have deemed necessary for the purposes of rendering this opinion and we are familiar with the proceedings taken and proposed to be taken by the Company in connection with the authorization, issuance and sale of the Shares. In our examination, we have assumed the genuineness of all signatures, the authenticity of all documents submitted to us as originals and the conformity with the originals of all documents submitted to us as copies.

This opinion letter is based as to matters of law solely on the Delaware General Corporation Law, as amended. We express no opinion herein as to any other laws, statutes, ordinances, rules, or regulations. As used herein, the term "Delaware General Corporation Law, as amended" includes the statutory provisions contained therein, all applicable provisions of the Delaware Constitution and reported judicial decisions interpreting these laws.

Based upon, subject to and limited by the foregoing, it is our opinion that following (i) effectiveness of the Registration Statement, (ii) issuance of the Shares pursuant to the terms of the Plan, and (iii) receipt by the Company of the consideration for the Shares specified in the applicable resolutions of the Board of Directors or a duly authorized committee thereof and the Plan, the Shares will be validly issued, fully paid and nonassessable.

This opinion letter has been prepared for use in connection with the Registration Statement. We assume no obligation to advise you of any changes in the foregoing subsequent to the effective date of the Registration Statement.

We consent to the use of this opinion as an exhibit to the Registration Statement, and we consent to the reference of our name wherever appearing in the Registration Statement and any amendments thereto. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act.

Very truly yours,

/s/ Morrison & Foerster LLP

## Exhibit 23.1

**Exhibit 23.1**

**CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM**

We consent to the incorporation by reference in this Registration Statement on Form S-8 of our report dated February 28, 2022, with respect to the consolidated financial statements of Krystal Biotech, Inc. (Company) as of December 31, 2021 and 2020 and for each of the two years in the period ended December 31, 2021, included in the Annual Report on Form 10-K for the year ended December 31, 2021.

/s/ Mayer Hoffman McCann P.C.

San Diego, California

February 2, 2023

<br>