# EDGAR Filing Document

**Accession Number:** 0001906594
**File Stem:** 0001906594-25-000006
**Filing Date:** 2025-11
**Character Count:** 53328
**Document Hash:** 0361078e7ddb4406752976c4b15d3b9b
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001906594-25-000006.hdr.sgml**: 20251110

**ACCESSION NUMBER**: 0001906594-25-000006

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20250930

**FILED AS OF DATE**: 20251110

**DATE AS OF CHANGE**: 20251110

**EFFECTIVENESS DATE**: 20251110

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** China Universal Asset Management Co., Ltd.
- **CENTRAL INDEX KEY:** 0001906594

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** F4
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-21774
- **FILM NUMBER:** 251464249

**BUSINESS ADDRESS:**
- **STREET 1:** CUAM BUILDING,728 WAIMA ROAD
- **CITY:** SHANGHAI
- **STATE:** F4
- **ZIP:** 200001
- **BUSINESS PHONE:** 862128932888

**MAIL ADDRESS:**
- **STREET 1:** CUAM BUILDING,728 WAIMA ROAD
- **CITY:** SHANGHAI
- **STATE:** F4
- **ZIP:** 200001

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 09-30-2025

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** China Universal Asset Management Co. Ltd.<br>**Address:** CUAM BUILDING728 WAIMA ROAD<br>SHANGHAI, F4 200001

**Form 13F File Number:** 028-21774

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Li Peng<br>**Title:** Chief Compliance Officer<br>**Phone:** 011-86-21-20373399

**Signature, Place, and Date of Signing:**

Li Peng  Shanghai, F4  11-10-2025<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 478

**Form 13F Information Table Value Total:** $1210258244

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| NVIDIA CORP | Common Stock | 67066G104 |  | 86243825 | 462213 | SH |  | SOLE |  | 462213 | 0 | 0 |
| MICROSOFT CORP | Common Stock | 594918104 |  | 75658510 | 146073 | SH |  | SOLE |  | 146073 | 0 | 0 |
| APPLE INC | Common Stock | 037833100 |  | 64063635 | 251595 | SH |  | SOLE |  | 251595 | 0 | 0 |
| AMAZON.COM INC | Common Stock | 023135106 |  | 53514040 | 243722 | SH |  | SOLE |  | 243722 | 0 | 0 |
| BROADCOM INC | Common Stock | 11135F101 |  | 48616527 | 147363 | SH |  | SOLE |  | 147363 | 0 | 0 |
| ALPHABET INC-CL A | Common Stock | 02079K305 |  | 36963355 | 152050 | SH |  | SOLE |  | 152050 | 0 | 0 |
| META PLATFORMS INC-CLASS A | Common Stock | 30303M102 |  | 35877401 | 48854 | SH |  | SOLE |  | 48854 | 0 | 0 |
| NETFLIX INC | Common Stock | 64110L106 |  | 23857309 | 19899 | SH |  | SOLE |  | 19899 | 0 | 0 |
| TESLA INC | Common Stock | 88160R101 |  | 21570699 | 48504 | SH |  | SOLE |  | 48504 | 0 | 0 |
| AMGEN INC | Common Stock | 031162100 |  | 18238022 | 64628 | SH |  | SOLE |  | 64628 | 0 | 0 |
| GILEAD SCIENCES INC | Common Stock | 375558103 |  | 17888205 | 161155 | SH |  | SOLE |  | 161155 | 0 | 0 |
| VERTEX PHARMACEUTICALS INC | Common Stock | 92532F100 |  | 17668447 | 45114 | SH |  | SOLE |  | 45114 | 0 | 0 |
| ALPHABET INC-CL C | Common Stock | 02079K107 |  | 17242853 | 70798 | SH |  | SOLE |  | 70798 | 0 | 0 |
| PALANTIR TECHNOLOGIES INC-A | Common Stock | 69608A108 |  | 15453710 | 84715 | SH |  | SOLE |  | 84715 | 0 | 0 |
| APPLOVIN CORP-CLASS A | Common Stock | 03831W108 |  | 14817013 | 20621 | SH |  | SOLE |  | 20621 | 0 | 0 |
| ISHARES GOLD TRUST MICRO | ETP | 46436F103 |  | 14726250 | 382500 | SH |  | SOLE |  | 382500 | 0 | 0 |
| COSTCO WHOLESALE CORP | Common Stock | 22160K105 |  | 14642541 | 15819 | SH |  | SOLE |  | 15819 | 0 | 0 |
| SPDR GOLD MINISHARES TRUST | ETP | 98149E303 |  | 14464340 | 189200 | SH |  | SOLE |  | 189200 | 0 | 0 |
| REGENERON PHARMACEUTICALS | Common Stock | 75886F107 |  | 12009525 | 21359 | SH |  | SOLE |  | 21359 | 0 | 0 |
| GRANITESHARES GOLD TRUST | ETP | 38748G101 |  | 11532180 | 303000 | SH |  | SOLE |  | 303000 | 0 | 0 |
| VISA INC-CLASS A SHARES | Common Stock | 92826C839 |  | 10639108 | 31165 | SH |  | SOLE |  | 31165 | 0 | 0 |
| ALNYLAM PHARMACEUTICALS INC | Common Stock | 02043Q107 |  | 10390872 | 22787 | SH |  | SOLE |  | 22787 | 0 | 0 |
| ASTRAZENECA PLC-SPONS ADR | ADR | 046353108 |  | 10248258 | 133580 | SH |  | SOLE |  | 133580 | 0 | 0 |
| ADVANCED MICRO DEVICES | Common Stock | 007903107 |  | 10075958 | 62278 | SH |  | SOLE |  | 62278 | 0 | 0 |
| SPDR GOLD SHARES | ETP | 78463V107 |  | 9833011 | 27662 | SH |  | SOLE |  | 27662 | 0 | 0 |
| GOLDMAN SACHS PHYSICAL GOLD | ETP | 38150K103 |  | 8843840 | 232000 | SH |  | SOLE |  | 232000 | 0 | 0 |
| KLA CORP | Common Stock | 482480100 |  | 8751760 | 8114 | SH |  | SOLE |  | 8114 | 0 | 0 |
| INTUIT INC | Common Stock | 461202103 |  | 8724858 | 12776 | SH |  | SOLE |  | 12776 | 0 | 0 |
| CISCO SYSTEMS INC | Common Stock | 17275R102 |  | 7847090 | 114690 | SH |  | SOLE |  | 114690 | 0 | 0 |
| SHOPIFY INC - CLASS A | Common Stock | 82509L107 |  | 7715534 | 51918 | SH |  | SOLE |  | 51918 | 0 | 0 |
| ISHARES SILVER TRUST | ETP | 46428Q109 |  | 7537623 | 177900 | SH |  | SOLE |  | 177900 | 0 | 0 |
| PALO ALTO NETWORKS INC | Common Stock | 697435105 |  | 7423578 | 36458 | SH |  | SOLE |  | 36458 | 0 | 0 |
| ANALOG DEVICES INC | Common Stock | 032654105 |  | 7330951 | 29837 | SH |  | SOLE |  | 29837 | 0 | 0 |
| BOOKING HOLDINGS INC | Common Stock | 09857L108 |  | 7321410 | 1356 | SH |  | SOLE |  | 1356 | 0 | 0 |
| TAIWAN SEMICONDUCTOR-SP ADR | ADR | 874039100 |  | 7217830 | 25784 | SH |  | SOLE |  | 25784 | 0 | 0 |
| T-MOBILE US INC | Common Stock | 872590104 |  | 7111980 | 29710 | SH |  | SOLE |  | 29710 | 0 | 0 |
| LAM RESEARCH CORP | Common Stock | 512807306 |  | 6694255 | 49911 | SH |  | SOLE |  | 49911 | 0 | 0 |
| MICRON TECHNOLOGY INC | Common Stock | 595112103 |  | 6616502 | 39544 | SH |  | SOLE |  | 39544 | 0 | 0 |
| LINDE PLC | Common Stock | G54950103 |  | 6450500 | 13580 | SH |  | SOLE |  | 13580 | 0 | 0 |
| AMPHENOL CORP-CL A | Common Stock | 032095101 |  | 5947128 | 48000 | SH |  | SOLE |  | 48000 | 0 | 0 |
| ORACLE CORP | Common Stock | 68389X105 |  | 5884103 | 20922 | SH |  | SOLE |  | 20922 | 0 | 0 |
| BRITISH AMERICAN TOB-SP ADR | ADR | 110448107 |  | 5677331 | 106958 | SH |  | SOLE |  | 106958 | 0 | 0 |
| PEPSICO INC | Common Stock | 713448108 |  | 5567042 | 39640 | SH |  | SOLE |  | 39640 | 0 | 0 |
| SYNOPSYS INC | Common Stock | 871607107 |  | 5543237 | 11235 | SH |  | SOLE |  | 11235 | 0 | 0 |
| DOORDASH INC - A | Common Stock | 25809K105 |  | 5540980 | 20372 | SH |  | SOLE |  | 20372 | 0 | 0 |
| ALIBABA GROUP HOLDING-SP ADR | ADR | 01609W102 |  | 5526868 | 30923 | SH |  | SOLE |  | 30923 | 0 | 0 |
| ABRDN PHYSICAL GOLD SHARES | ETP | 00326A104 |  | 5374260 | 146000 | SH |  | SOLE |  | 146000 | 0 | 0 |
| INSMED INC | Common Stock | 457669307 |  | 5335715 | 37051 | SH |  | SOLE |  | 37051 | 0 | 0 |
| INTEL CORP | Common Stock | 458140100 |  | 5151569 | 153549 | SH |  | SOLE |  | 153549 | 0 | 0 |
| MASTERCARD INC - A | Common Stock | 57636Q104 |  | 5150006 | 9054 | SH |  | SOLE |  | 9054 | 0 | 0 |
| INTUITIVE SURGICAL INC | Common Stock | 46120E602 |  | 5126597 | 11463 | SH |  | SOLE |  | 11463 | 0 | 0 |
| MERCADOLIBRE INC | Common Stock | 58733R102 |  | 5089855 | 2178 | SH |  | SOLE |  | 2178 | 0 | 0 |
| QUALCOMM INC | Common Stock | 747525103 |  | 5071485 | 30485 | SH |  | SOLE |  | 30485 | 0 | 0 |
| ADOBE INC | Common Stock | 00724F101 |  | 4797047 | 13599 | SH |  | SOLE |  | 13599 | 0 | 0 |
| HOME DEPOT INC | Common Stock | 437076102 |  | 4630511 | 11428 | SH |  | SOLE |  | 11428 | 0 | 0 |
| TEXAS INSTRUMENTS INC | Common Stock | 882508104 |  | 4409520 | 24000 | SH |  | SOLE |  | 24000 | 0 | 0 |
| SEA LTD-ADR | ADR | 81141R100 |  | 4361012 | 24400 | SH |  | SOLE |  | 24400 | 0 | 0 |
| CROWDSTRIKE HOLDINGS INC - A | Common Stock | 22788C105 |  | 4327604 | 8825 | SH |  | SOLE |  | 8825 | 0 | 0 |
| ELI LILLY  CO | Common Stock | 532457108 |  | 4314765 | 5655 | SH |  | SOLE |  | 5655 | 0 | 0 |
| APPLIED MATERIALS INC | Common Stock | 038222105 |  | 4305887 | 21031 | SH |  | SOLE |  | 21031 | 0 | 0 |
| UNITED THERAPEUTICS CORP | Common Stock | 91307C102 |  | 4161498 | 9927 | SH |  | SOLE |  | 9927 | 0 | 0 |
| BIOGEN INC | Common Stock | 09062X103 |  | 4142166 | 29570 | SH |  | SOLE |  | 29570 | 0 | 0 |
| NETEASE INC-ADR | ADR | 64110W102 |  | 3966939 | 26100 | SH |  | SOLE |  | 26100 | 0 | 0 |
| ARGENX SE - ADR | ADR | 04016X101 |  | 3957747 | 5366 | SH |  | SOLE |  | 5366 | 0 | 0 |
| PDD HOLDINGS INC | ADR | 722304102 |  | 3747945 | 28357 | SH |  | SOLE |  | 28357 | 0 | 0 |
| CADENCE DESIGN SYS INC | Common Stock | 127387108 |  | 3721248 | 10594 | SH |  | SOLE |  | 10594 | 0 | 0 |
| UBER TECHNOLOGIES INC | Common Stock | 90353T100 |  | 3651146 | 37268 | SH |  | SOLE |  | 37268 | 0 | 0 |
| PROSHARES ULTRA GOLD | ETP | 74347W601 |  | 3583468 | 77800 | SH |  | SOLE |  | 77800 | 0 | 0 |
| SERVICENOW INC | Common Stock | 81762P102 |  | 3578049 | 3888 | SH |  | SOLE |  | 3888 | 0 | 0 |
| HONEYWELL INTERNATIONAL INC | Common Stock | 438516106 |  | 3528191 | 16761 | SH |  | SOLE |  | 16761 | 0 | 0 |
| FULL TRUCK ALLIANCE -SPN ADR | ADR | 35969L108 |  | 3462990 | 267000 | SH |  | SOLE |  | 267000 | 0 | 0 |
| JOHNSON  JOHNSON | Common Stock | 478160104 |  | 3455858 | 18638 | SH |  | SOLE |  | 18638 | 0 | 0 |
| FUTU HOLDINGS LTD-ADR | ADR | 36118L106 |  | 3439244 | 19776 | SH |  | SOLE |  | 19776 | 0 | 0 |
| ISHARES GOLD TRUST | ETP | 464285204 |  | 3347420 | 46000 | SH |  | SOLE |  | 46000 | 0 | 0 |
| SANOFI-ADR | ADR | 80105N105 |  | 3239478 | 68633 | SH |  | SOLE |  | 68633 | 0 | 0 |
| AUTOMATIC DATA PROCESSING | Common Stock | 053015103 |  | 3153174 | 10693 | SH |  | SOLE |  | 10693 | 0 | 0 |
| AUTODESK INC | Common Stock | 052769106 |  | 3128732 | 9849 | SH |  | SOLE |  | 9849 | 0 | 0 |
| BOSTON SCIENTIFIC CORP | Common Stock | 101137107 |  | 3124160 | 32000 | SH |  | SOLE |  | 32000 | 0 | 0 |
| CELESTICA INC | Common Stock | 15101Q207 |  | 3055112 | 12400 | SH |  | SOLE |  | 12400 | 0 | 0 |
| COMCAST CORP-CLASS A | Common Stock | 20030N101 |  | 3054715 | 97222 | SH |  | SOLE |  | 97222 | 0 | 0 |
| INCYTE CORP | Common Stock | 45337C102 |  | 2902961 | 34229 | SH |  | SOLE |  | 34229 | 0 | 0 |
| ROYAL CARIBBEAN CRUISES LTD | Common Stock | V7780T103 |  | 2720865 | 8399 | SH |  | SOLE |  | 8399 | 0 | 0 |
| CONSTELLATION ENERGY | Common Stock | 21037T109 |  | 2713840 | 8247 | SH |  | SOLE |  | 8247 | 0 | 0 |
| SUMMIT THERAPEUTICS INC | Common Stock | 86627T108 |  | 2690139 | 130210 | SH |  | SOLE |  | 130210 | 0 | 0 |
| NIKE INC -CL B | Common Stock | 654106103 |  | 2679120 | 38366 | SH |  | SOLE |  | 38366 | 0 | 0 |
| ROYALTY PHARMA PLC- CL A | Common Stock | G7709Q104 |  | 2673342 | 75775 | SH |  | SOLE |  | 75775 | 0 | 0 |
| MERCK  CO. INC. | Common Stock | 58933Y105 |  | 2658801 | 31406 | SH |  | SOLE |  | 31406 | 0 | 0 |
| FORTINET INC | Common Stock | 34959E109 |  | 2625734 | 31229 | SH |  | SOLE |  | 31229 | 0 | 0 |
| TRIP.COM GROUP LTD-ADR | ADR | 89677Q107 |  | 2594400 | 34500 | SH |  | SOLE |  | 34500 | 0 | 0 |
| NOVARTIS AG-SPONSORED ADR | ADR | 66987V109 |  | 2564800 | 20000 | SH |  | SOLE |  | 20000 | 0 | 0 |
| STARBUCKS CORP | Common Stock | 855244109 |  | 2546798 | 30104 | SH |  | SOLE |  | 30104 | 0 | 0 |
| MEDPACE HOLDINGS INC | Common Stock | 58506Q109 |  | 2531724 | 4924 | SH |  | SOLE |  | 4924 | 0 | 0 |
| ABBVIE INC | Common Stock | 00287Y109 |  | 2525175 | 10906 | SH |  | SOLE |  | 10906 | 0 | 0 |
| ATRENEW INC | ADR | 00138L108 |  | 2465600 | 536000 | SH |  | SOLE |  | 536000 | 0 | 0 |
| ASML HOLDING NV-NY REG SHS | NY Reg Shrs | N07059210 |  | 2456044 | 2537 | SH |  | SOLE |  | 2537 | 0 | 0 |
| NEUROCRINE BIOSCIENCES INC | Common Stock | 64125C109 |  | 2440506 | 17385 | SH |  | SOLE |  | 17385 | 0 | 0 |
| TENET HEALTHCARE CORP | Common Stock | 88033G407 |  | 2436480 | 12000 | SH |  | SOLE |  | 12000 | 0 | 0 |
| O'REILLY AUTOMOTIVE INC | Common Stock | 67103H107 |  | 2414944 | 22400 | SH |  | SOLE |  | 22400 | 0 | 0 |
| WORKDAY INC-CLASS A | Common Stock | 98138H101 |  | 2402245 | 9979 | SH |  | SOLE |  | 9979 | 0 | 0 |
| TEMPUS AI INC | Common Stock | 88023B103 |  | 2386433 | 29568 | SH |  | SOLE |  | 29568 | 0 | 0 |
| SAP SE-SPONSORED ADR | ADR | 803054204 |  | 2298006 | 8600 | SH |  | SOLE |  | 8600 | 0 | 0 |
| TENCENT MUSIC ENTERTAINM-ADR | ADR | 88034P109 |  | 2287320 | 98000 | SH |  | SOLE |  | 98000 | 0 | 0 |
| ROBLOX CORP -CLASS A | Common Stock | 771049103 |  | 2285580 | 16500 | SH |  | SOLE |  | 16500 | 0 | 0 |
| STRATEGY INC | Common Stock | 594972408 |  | 2244837 | 6967 | SH |  | SOLE |  | 6967 | 0 | 0 |
| JPMORGAN CHASE  CO | Common Stock | 46625H100 |  | 2236399 | 7090 | SH |  | SOLE |  | 7090 | 0 | 0 |
| CINTAS CORP | Common Stock | 172908105 |  | 2183556 | 10638 | SH |  | SOLE |  | 10638 | 0 | 0 |
| MONDELEZ INTERNATIONAL INC-A | Common Stock | 609207105 |  | 2149272 | 34159 | SH |  | SOLE |  | 34159 | 0 | 0 |
| ASCENDIS PHARMA A/S - ADR | ADR | 04351P101 |  | 2120706 | 10667 | SH |  | SOLE |  | 10667 | 0 | 0 |
| VIATRIS INC | Common Stock | 92556V106 |  | 2023164 | 204360 | SH |  | SOLE |  | 204360 | 0 | 0 |
| ZSCALER INC | Common Stock | 98980G102 |  | 2010719 | 6710 | SH |  | SOLE |  | 6710 | 0 | 0 |
| BEONE MEDICINES LTD-ADR | ADR | 07725L102 |  | 2007404 | 5892 | SH |  | SOLE |  | 5892 | 0 | 0 |
| REVOLUTION MEDICINES INC | Common Stock | 76155X100 |  | 1997219 | 42767 | SH |  | SOLE |  | 42767 | 0 | 0 |
| ASTERA LABS INC | Common Stock | 04626A103 |  | 1997160 | 10200 | SH |  | SOLE |  | 10200 | 0 | 0 |
| EXELIXIS INC | Common Stock | 30161Q104 |  | 1948823 | 47187 | SH |  | SOLE |  | 47187 | 0 | 0 |
| THERMO FISHER SCIENTIFIC INC | Common Stock | 883556102 |  | 1923668 | 3963 | SH |  | SOLE |  | 3963 | 0 | 0 |
| MARVELL TECHNOLOGY INC | Common Stock | 573874104 |  | 1913349 | 22759 | SH |  | SOLE |  | 22759 | 0 | 0 |
| MARRIOTT INTERNATIONAL -CL A | Common Stock | 571903202 |  | 1866313 | 7166 | SH |  | SOLE |  | 7166 | 0 | 0 |
| CREDO TECHNOLOGY GROUP HOLDI | Common Stock | G25457105 |  | 1863808 | 12800 | SH |  | SOLE |  | 12800 | 0 | 0 |
| THOMSON REUTERS CORP | Common Stock | 884903808 |  | 1848116 | 11898 | SH |  | SOLE |  | 11898 | 0 | 0 |
| IONIS PHARMACEUTICALS INC | Common Stock | 462222100 |  | 1827769 | 27939 | SH |  | SOLE |  | 27939 | 0 | 0 |
| BIOMARIN PHARMACEUTICAL INC | Common Stock | 09061G101 |  | 1822863 | 33657 | SH |  | SOLE |  | 33657 | 0 | 0 |
| ROIVANT SCIENCES LTD | Common Stock | G76279101 |  | 1811046 | 119699 | SH |  | SOLE |  | 119699 | 0 | 0 |
| MADRIGAL PHARMACEUTICALS INC | Common Stock | 558868105 |  | 1791985 | 3907 | SH |  | SOLE |  | 3907 | 0 | 0 |
| MODERNA INC | Common Stock | 60770K107 |  | 1761606 | 68200 | SH |  | SOLE |  | 68200 | 0 | 0 |
| CVS HEALTH CORP | Common Stock | 126650100 |  | 1756587 | 23300 | SH |  | SOLE |  | 23300 | 0 | 0 |
| CSX CORP | Common Stock | 126408103 |  | 1747625 | 49215 | SH |  | SOLE |  | 49215 | 0 | 0 |
| BRIDGEBIO PHARMA INC | Common Stock | 10806X102 |  | 1740457 | 33509 | SH |  | SOLE |  | 33509 | 0 | 0 |
| BIONTECH SE-ADR | ADR | 09075V102 |  | 1739065 | 17634 | SH |  | SOLE |  | 17634 | 0 | 0 |
| BERKSHIRE HATHAWAY INC-CL B | Common Stock | 084670702 |  | 1737972 | 3457 | SH |  | SOLE |  | 3457 | 0 | 0 |
| MONSTER BEVERAGE CORP | Common Stock | 61174X109 |  | 1735050 | 25777 | SH |  | SOLE |  | 25777 | 0 | 0 |
| PAYPAL HOLDINGS INC | Common Stock | 70450Y103 |  | 1691320 | 25221 | SH |  | SOLE |  | 25221 | 0 | 0 |
| AMERICAN ELECTRIC POWER | Common Stock | 025537101 |  | 1588275 | 14118 | SH |  | SOLE |  | 14118 | 0 | 0 |
| VERONA PHARMA PLC - ADR | ADR | 925050106 |  | 1583363 | 14838 | SH |  | SOLE |  | 14838 | 0 | 0 |
| NXP SEMICONDUCTORS NV | Common Stock | N6596X109 |  | 1521478 | 6656 | SH |  | SOLE |  | 6656 | 0 | 0 |
| HALOZYME THERAPEUTICS INC | Common Stock | 40637H109 |  | 1503617 | 20502 | SH |  | SOLE |  | 20502 | 0 | 0 |
| AXON ENTERPRISE INC | Common Stock | 05464C101 |  | 1486950 | 2072 | SH |  | SOLE |  | 2072 | 0 | 0 |
| FASTENAL CO | Common Stock | 311900104 |  | 1485765 | 30297 | SH |  | SOLE |  | 30297 | 0 | 0 |
| ARROWHEAD PHARMACEUTICALS IN | Common Stock | 04280A100 |  | 1456651 | 42234 | SH |  | SOLE |  | 42234 | 0 | 0 |
| ROPER TECHNOLOGIES INC | Common Stock | 776696106 |  | 1416778 | 2841 | SH |  | SOLE |  | 2841 | 0 | 0 |
| JAZZ PHARMACEUTICALS PLC | Common Stock | G50871105 |  | 1401429 | 10633 | SH |  | SOLE |  | 10633 | 0 | 0 |
| LUMENTUM HOLDINGS INC | Common Stock | 55024U109 |  | 1383035 | 8500 | SH |  | SOLE |  | 8500 | 0 | 0 |
| TTM TECHNOLOGIES | Common Stock | 87305R109 |  | 1382400 | 24000 | SH |  | SOLE |  | 24000 | 0 | 0 |
| PROCTER  GAMBLE CO/THE | Common Stock | 742718109 |  | 1380545 | 8985 | SH |  | SOLE |  | 8985 | 0 | 0 |
| AIRBNB INC-CLASS A | Common Stock | 009066101 |  | 1375324 | 11327 | SH |  | SOLE |  | 11327 | 0 | 0 |
| GUARDANT HEALTH INC | Common Stock | 40131M109 |  | 1365750 | 21859 | SH |  | SOLE |  | 21859 | 0 | 0 |
| PACCAR INC | Common Stock | 693718108 |  | 1362912 | 13862 | SH |  | SOLE |  | 13862 | 0 | 0 |
| UNITEDHEALTH GROUP INC | Common Stock | 91324P102 |  | 1351504 | 3914 | SH |  | SOLE |  | 3914 | 0 | 0 |
| IDEXX LABORATORIES INC | Common Stock | 45168D104 |  | 1349336 | 2112 | SH |  | SOLE |  | 2112 | 0 | 0 |
| ELECTRONIC ARTS INC | Common Stock | 285512109 |  | 1332229 | 6605 | SH |  | SOLE |  | 6605 | 0 | 0 |
| ROSS STORES INC | Common Stock | 778296103 |  | 1318864 | 8634 | SH |  | SOLE |  | 8634 | 0 | 0 |
| WARNER BROS DISCOVERY INC | Common Stock | 934423104 |  | 1276442 | 65358 | SH |  | SOLE |  | 65358 | 0 | 0 |
| KYMERA THERAPEUTICS INC | Common Stock | 501575104 |  | 1275311 | 22532 | SH |  | SOLE |  | 22532 | 0 | 0 |
| BAKER HUGHES CO | Common Stock | 05722G100 |  | 1267987 | 26026 | SH |  | SOLE |  | 26026 | 0 | 0 |
| XCEL ENERGY INC | Common Stock | 98389B100 |  | 1266977 | 15613 | SH |  | SOLE |  | 15613 | 0 | 0 |
| AMER SPORTS INC | Common Stock | G0260P102 |  | 1262363 | 36327 | SH |  | SOLE |  | 36327 | 0 | 0 |
| TAKE-TWO INTERACTIVE SOFTWRE | Common Stock | 874054109 |  | 1258213 | 4870 | SH |  | SOLE |  | 4870 | 0 | 0 |
| COHERENT CORP | Common Stock | 19247G107 |  | 1249552 | 11600 | SH |  | SOLE |  | 11600 | 0 | 0 |
| MERUS NV | Common Stock | N5749R100 |  | 1248241 | 13258 | SH |  | SOLE |  | 13258 | 0 | 0 |
| LOWE'S COS INC | Common Stock | 548661107 |  | 1240717 | 4937 | SH |  | SOLE |  | 4937 | 0 | 0 |
| SNOWFLAKE INC | Common Stock | 833445109 |  | 1240525 | 5500 | SH |  | SOLE |  | 5500 | 0 | 0 |
| EXXON MOBIL CORP | Common Stock | 30231G102 |  | 1239574 | 10994 | SH |  | SOLE |  | 10994 | 0 | 0 |
| SPOTIFY TECHNOLOGY SA | Common Stock | L8681T102 |  | 1221500 | 1750 | SH |  | SOLE |  | 1750 | 0 | 0 |
| DATADOG INC - CLASS A | Common Stock | 23804L103 |  | 1215242 | 8534 | SH |  | SOLE |  | 8534 | 0 | 0 |
| PAYCHEX INC | Common Stock | 704326107 |  | 1203333 | 9493 | SH |  | SOLE |  | 9493 | 0 | 0 |
| EXELON CORP | Common Stock | 30161N101 |  | 1200102 | 26663 | SH |  | SOLE |  | 26663 | 0 | 0 |
| MCKESSON CORP | Common Stock | 58155Q103 |  | 1197034 | 1548 | SH |  | SOLE |  | 1548 | 0 | 0 |
| RHYTHM PHARMACEUTICALS INC | Common Stock | 76243J105 |  | 1175726 | 11642 | SH |  | SOLE |  | 11642 | 0 | 0 |
| WALMART INC | Common Stock | 931142103 |  | 1153963 | 11197 | SH |  | SOLE |  | 11197 | 0 | 0 |
| CYTOKINETICS INC | Common Stock | 23282W605 |  | 1152731 | 20974 | SH |  | SOLE |  | 20974 | 0 | 0 |
| COPART INC | Common Stock | 217204106 |  | 1147904 | 25526 | SH |  | SOLE |  | 25526 | 0 | 0 |
| ATLASSIAN CORP-CL A | Common Stock | 049468101 |  | 1132273 | 7090 | SH |  | SOLE |  | 7090 | 0 | 0 |
| COCA-COLA EUROPACIFIC PARTNE | Common Stock | G25839104 |  | 1093599 | 12096 | SH |  | SOLE |  | 12096 | 0 | 0 |
| DIAMONDBACK ENERGY INC | Common Stock | 25278X109 |  | 1093570 | 7642 | SH |  | SOLE |  | 7642 | 0 | 0 |
| MONDAY.COM LTD | Common Stock | M7S64H106 |  | 1065295 | 5500 | SH |  | SOLE |  | 5500 | 0 | 0 |
| AXSOME THERAPEUTICS INC | Common Stock | 05464T104 |  | 1062323 | 8747 | SH |  | SOLE |  | 8747 | 0 | 0 |
| PROTAGONIST THERAPEUTICS INC | Common Stock | 74366E102 |  | 1056569 | 15905 | SH |  | SOLE |  | 15905 | 0 | 0 |
| CRISPR THERAPEUTICS AG | Common Stock | H17182108 |  | 1033201 | 15942 | SH |  | SOLE |  | 15942 | 0 | 0 |
| MCDONALD'S CORP | Common Stock | 580135101 |  | 1015904 | 3343 | SH |  | SOLE |  | 3343 | 0 | 0 |
| NUVALENT INC-A | Common Stock | 670703107 |  | 1010605 | 11686 | SH |  | SOLE |  | 11686 | 0 | 0 |
| CHARTER COMMUNICATIONS INC-A | Common Stock | 16119P108 |  | 992029 | 3606 | SH |  | SOLE |  | 3606 | 0 | 0 |
| AVIDITY BIOSCIENCES INC | Common Stock | 05370A108 |  | 982547 | 22551 | SH |  | SOLE |  | 22551 | 0 | 0 |
| ELEVANCE HEALTH INC | Common Stock | 036752103 |  | 969360 | 3000 | SH |  | SOLE |  | 3000 | 0 | 0 |
| COSTAR GROUP INC | Common Stock | 22160N109 |  | 943594 | 11184 | SH |  | SOLE |  | 11184 | 0 | 0 |
| BANK OF AMERICA CORP | Common Stock | 060505104 |  | 941672 | 18253 | SH |  | SOLE |  | 18253 | 0 | 0 |
| VERISK ANALYTICS INC | Common Stock | 92345Y106 |  | 927569 | 3688 | SH |  | SOLE |  | 3688 | 0 | 0 |
| KEURIG DR PEPPER INC | Common Stock | 49271V100 |  | 922247 | 35862 | SH |  | SOLE |  | 35862 | 0 | 0 |
| MICROCHIP TECHNOLOGY INC | Common Stock | 595017104 |  | 914942 | 14247 | SH |  | SOLE |  | 14247 | 0 | 0 |
| GE HEALTHCARE TECHNOLOGY | Common Stock | 36266G107 |  | 905180 | 12053 | SH |  | SOLE |  | 12053 | 0 | 0 |
| KRYSTAL BIOTECH INC | Common Stock | 501147102 |  | 895537 | 5073 | SH |  | SOLE |  | 5073 | 0 | 0 |
| ALKERMES PLC | Common Stock | G01767105 |  | 868080 | 28936 | SH |  | SOLE |  | 28936 | 0 | 0 |
| COGNIZANT TECH SOLUTIONS-A | Common Stock | 192446102 |  | 864734 | 12893 | SH |  | SOLE |  | 12893 | 0 | 0 |
| PTC THERAPEUTICS INC | Common Stock | 69366J200 |  | 854516 | 13924 | SH |  | SOLE |  | 13924 | 0 | 0 |
| RAMBUS INC | Common Stock | 750917106 |  | 833600 | 8000 | SH |  | SOLE |  | 8000 | 0 | 0 |
| VAXCYTE INC | Common Stock | 92243G108 |  | 819671 | 22756 | SH |  | SOLE |  | 22756 | 0 | 0 |
| GENERAL ELECTRIC | Common Stock | 369604301 |  | 819112 | 2720 | SH |  | SOLE |  | 2720 | 0 | 0 |
| KRAFT HEINZ CO/THE | Common Stock | 500754106 |  | 813646 | 31246 | SH |  | SOLE |  | 31246 | 0 | 0 |
| ARISTA NETWORKS INC | Common Stock | 040413205 |  | 801405 | 5500 | SH |  | SOLE |  | 5500 | 0 | 0 |
| ARCELLX INC | Common Stock | 03940C100 |  | 798094 | 9721 | SH |  | SOLE |  | 9721 | 0 | 0 |
| DUOLINGO | Common Stock | 26603R106 |  | 784968 | 2439 | SH |  | SOLE |  | 2439 | 0 | 0 |
| OLD DOMINION FREIGHT LINE | Common Stock | 679580100 |  | 781047 | 5548 | SH |  | SOLE |  | 5548 | 0 | 0 |
| CHEVRON CORP | Common Stock | 166764100 |  | 776605 | 5001 | SH |  | SOLE |  | 5001 | 0 | 0 |
| LI AUTO INC - ADR | ADR | 50202M102 |  | 760200 | 30000 | SH |  | SOLE |  | 30000 | 0 | 0 |
| STRYKER CORP | Common Stock | 863667101 |  | 740852 | 2000 | SH |  | SOLE |  | 2000 | 0 | 0 |
| CONSUMER DISCRETIONARY SELT | ETP | 81369Y407 |  | 722515 | 3015 | SH |  | SOLE |  | 3015 | 0 | 0 |
| TJX COMPANIES INC | Common Stock | 872540109 |  | 718364 | 4970 | SH |  | SOLE |  | 4970 | 0 | 0 |
| JOYY INC-ADR | ADR | 46591M109 |  | 714660 | 12000 | SH |  | SOLE |  | 12000 | 0 | 0 |
| OCULAR THERAPEUTIX INC | Common Stock | 67576A100 |  | 707233 | 60499 | SH |  | SOLE |  | 60499 | 0 | 0 |
| RUBRIK INC-A | Common Stock | 781154109 |  | 699125 | 8500 | SH |  | SOLE |  | 8500 | 0 | 0 |
| DEXCOM INC | Common Stock | 252131107 |  | 696653 | 10353 | SH |  | SOLE |  | 10353 | 0 | 0 |
| COCA-COLA CO/THE | Common Stock | 191216100 |  | 696572 | 10431 | SH |  | SOLE |  | 10431 | 0 | 0 |
| WELLS FARGO  CO | Common Stock | 949746101 |  | 688581 | 8215 | SH |  | SOLE |  | 8215 | 0 | 0 |
| CRINETICS PHARMACEUTICALS IN | Common Stock | 22663K107 |  | 687558 | 16508 | SH |  | SOLE |  | 16508 | 0 | 0 |
| INTELLIA THERAPEUTICS INC | Common Stock | 45826J105 |  | 670352 | 38816 | SH |  | SOLE |  | 38816 | 0 | 0 |
| INTL BUSINESS MACHINES CORP | Common Stock | 459200101 |  | 669001 | 2371 | SH |  | SOLE |  | 2371 | 0 | 0 |
| REPLIGEN CORP | Common Stock | 759916109 |  | 668350 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| AKERO THERAPEUTICS INC | Common Stock | 00973Y108 |  | 665717 | 14021 | SH |  | SOLE |  | 14021 | 0 | 0 |
| ON SEMICONDUCTOR | Common Stock | 682189105 |  | 655675 | 13297 | SH |  | SOLE |  | 13297 | 0 | 0 |
| MIRUM PHARMACEUTICALS INC | Common Stock | 604749101 |  | 645568 | 8806 | SH |  | SOLE |  | 8806 | 0 | 0 |
| PHILIP MORRIS INTERNATIONAL | Common Stock | 718172109 |  | 644096 | 3971 | SH |  | SOLE |  | 3971 | 0 | 0 |
| SUPERNUS PHARMACEUTICALS INC | Common Stock | 868459108 |  | 641772 | 13429 | SH |  | SOLE |  | 13429 | 0 | 0 |
| ACADIA PHARMACEUTICALS INC | Common Stock | 004225108 |  | 631088 | 29573 | SH |  | SOLE |  | 29573 | 0 | 0 |
| SCHOLAR ROCK HOLDING CORP | Common Stock | 80706P103 |  | 627494 | 16850 | SH |  | SOLE |  | 16850 | 0 | 0 |
| BEAM THERAPEUTICS INC | Common Stock | 07373V105 |  | 624516 | 25732 | SH |  | SOLE |  | 25732 | 0 | 0 |
| GOLDMAN SACHS GROUP INC | Common Stock | 38141G104 |  | 623542 | 783 | SH |  | SOLE |  | 783 | 0 | 0 |
| ADMA BIOLOGICS INC | Common Stock | 000899104 |  | 613198 | 41828 | SH |  | SOLE |  | 41828 | 0 | 0 |
| LIGAND PHARMACEUTICALS | Common Stock | 53220K504 |  | 608476 | 3435 | SH |  | SOLE |  | 3435 | 0 | 0 |
| ABBOTT LABORATORIES | Common Stock | 002824100 |  | 594426 | 4438 | SH |  | SOLE |  | 4438 | 0 | 0 |
| SALESFORCE INC | Common Stock | 79466L302 |  | 578956 | 2439 | SH |  | SOLE |  | 2439 | 0 | 0 |
| TRADE DESK INC/THE -CLASS A | Common Stock | 88339J105 |  | 576603 | 11765 | SH |  | SOLE |  | 11765 | 0 | 0 |
| CATERPILLAR INC | Common Stock | 149123101 |  | 572580 | 1200 | SH |  | SOLE |  | 1200 | 0 | 0 |
| RTX CORP | Common Stock | 75513E101 |  | 570261 | 3408 | SH |  | SOLE |  | 3408 | 0 | 0 |
| WAVE LIFE SCIENCES LTD | Common Stock | Y95308105 |  | 570191 | 77895 | SH |  | SOLE |  | 77895 | 0 | 0 |
| HESAI GROUP | ADR | 428050108 |  | 562000 | 20000 | SH |  | SOLE |  | 20000 | 0 | 0 |
| NEWAMSTERDAM PHARMA CO NV | Common Stock | N62509109 |  | 561462 | 19742 | SH |  | SOLE |  | 19742 | 0 | 0 |
| UNIQURE NV | Common Stock | N90064101 |  | 561344 | 9617 | SH |  | SOLE |  | 9617 | 0 | 0 |
| CDW CORP/DE | Common Stock | 12514G108 |  | 551109 | 3460 | SH |  | SOLE |  | 3460 | 0 | 0 |
| AMNEAL PHARMACEUTICALS INC | Common Stock | 03168L105 |  | 551081 | 55053 | SH |  | SOLE |  | 55053 | 0 | 0 |
| XENON PHARMACEUTICALS INC | Common Stock | 98420N105 |  | 542627 | 13515 | SH |  | SOLE |  | 13515 | 0 | 0 |
| LULULEMON ATHLETICA INC | Common Stock | 550021109 |  | 538950 | 3029 | SH |  | SOLE |  | 3029 | 0 | 0 |
| CG ONCOLOGY INC | Common Stock | 156944100 |  | 538342 | 13365 | SH |  | SOLE |  | 13365 | 0 | 0 |
| INDIVIOR PLC | Common Stock | G4766E116 |  | 527286 | 21870 | SH |  | SOLE |  | 21870 | 0 | 0 |
| WALT DISNEY CO/THE | Common Stock | 254687106 |  | 525097 | 4586 | SH |  | SOLE |  | 4586 | 0 | 0 |
| GLOBALFOUNDRIES INC | Common Stock | G39387108 |  | 525092 | 14651 | SH |  | SOLE |  | 14651 | 0 | 0 |
| GRAIL INC | Common Stock | 384747101 |  | 521467 | 8819 | SH |  | SOLE |  | 8819 | 0 | 0 |
| AT INC | Common Stock | 00206R102 |  | 518373 | 18356 | SH |  | SOLE |  | 18356 | 0 | 0 |
| ARM HOLDINGS PLC-ADR | ADR | 042068205 |  | 510213 | 3606 | SH |  | SOLE |  | 3606 | 0 | 0 |
| ULTRAGENYX PHARMACEUTICAL IN | Common Stock | 90400D108 |  | 508141 | 16893 | SH |  | SOLE |  | 16893 | 0 | 0 |
| FERRARI NV | Common Stock | N3167Y103 |  | 504144 | 1039 | SH |  | SOLE |  | 1039 | 0 | 0 |
| APELLIS PHARMACEUTICALS INC | Common Stock | 03753U106 |  | 500960 | 22137 | SH |  | SOLE |  | 22137 | 0 | 0 |
| SPDR S BIOTECH ETF | ETP | 78464A870 |  | 492884 | 4919 | SH |  | SOLE |  | 4919 | 0 | 0 |
| IMMUNOVANT INC | Common Stock | 45258J102 |  | 492547 | 30555 | SH |  | SOLE |  | 30555 | 0 | 0 |
| LEGEND BIOTECH CORP-ADR | ADR | 52490G102 |  | 481291 | 14759 | SH |  | SOLE |  | 14759 | 0 | 0 |
| VERACYTE INC | Common Stock | 92337F107 |  | 473411 | 13790 | SH |  | SOLE |  | 13790 | 0 | 0 |
| VERIZON COMMUNICATIONS INC | Common Stock | 92343V104 |  | 472726 | 10756 | SH |  | SOLE |  | 10756 | 0 | 0 |
| DISC MEDICINE INC | Common Stock | 254604101 |  | 468772 | 7094 | SH |  | SOLE |  | 7094 | 0 | 0 |
| ADAPTIVE BIOTECHNOLOGIES | Common Stock | 00650F109 |  | 453153 | 30291 | SH |  | SOLE |  | 30291 | 0 | 0 |
| BRISTOL-MYERS SQUIBB CO | Common Stock | 110122108 |  | 451000 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| ALVOTECH SA | Common Stock | L01800108 |  | 449369 | 54868 | SH |  | SOLE |  | 54868 | 0 | 0 |
| MINERALYS THERAPEUTICS INC | Common Stock | 603170101 |  | 440668 | 11621 | SH |  | SOLE |  | 11621 | 0 | 0 |
| TARSUS PHARMACEUTICALS INC | Common Stock | 87650L103 |  | 439782 | 7400 | SH |  | SOLE |  | 7400 | 0 | 0 |
| ZETA GLOBAL HOLDINGS CORP-A | Common Stock | 98956A105 |  | 437140 | 22000 | SH |  | SOLE |  | 22000 | 0 | 0 |
| AUTOZONE INC | Common Stock | 053332102 |  | 429024 | 100 | SH |  | SOLE |  | 100 | 0 | 0 |
| AMICUS THERAPEUTICS INC | Common Stock | 03152W109 |  | 425756 | 54030 | SH |  | SOLE |  | 54030 | 0 | 0 |
| IDEAYA BIOSCIENCES INC | Common Stock | 45166A102 |  | 418027 | 15363 | SH |  | SOLE |  | 15363 | 0 | 0 |
| AGIOS PHARMACEUTICALS INC | Common Stock | 00847X104 |  | 408786 | 10184 | SH |  | SOLE |  | 10184 | 0 | 0 |
| CENTESSA PHARMACEUTICALS-ADR | ADR | 152309100 |  | 407788 | 16816 | SH |  | SOLE |  | 16816 | 0 | 0 |
| IMMUNITYBIO INC | Common Stock | 45256X103 |  | 407595 | 165689 | SH |  | SOLE |  | 165689 | 0 | 0 |
| KANZHUN LTD - ADR | ADR | 48553T106 |  | 404128 | 17300 | SH |  | SOLE |  | 17300 | 0 | 0 |
| H WORLD GROUP LTD-ADR | ADR | 44332N106 |  | 398922 | 10200 | SH |  | SOLE |  | 10200 | 0 | 0 |
| ARCUTIS BIOTHERAPEUTICS INC | Common Stock | 03969K108 |  | 396189 | 21018 | SH |  | SOLE |  | 21018 | 0 | 0 |
| DECKERS OUTDOOR CORP | Common Stock | 243537107 |  | 396154 | 3908 | SH |  | SOLE |  | 3908 | 0 | 0 |
| DIAGEO PLC-SPONSORED ADR | ADR | 25243Q205 |  | 392885 | 4117 | SH |  | SOLE |  | 4117 | 0 | 0 |
| 89BIO INC | Common Stock | 282559103 |  | 382141 | 25996 | SH |  | SOLE |  | 25996 | 0 | 0 |
| TRAVERE THERAPEUTICS INC | Common Stock | 89422G107 |  | 373438 | 15625 | SH |  | SOLE |  | 15625 | 0 | 0 |
| LENZ THERAPEUTICS INC | Common Stock | 52635N103 |  | 372593 | 7999 | SH |  | SOLE |  | 7999 | 0 | 0 |
| DENALI THERAPEUTICS INC | Common Stock | 24823R105 |  | 372133 | 25629 | SH |  | SOLE |  | 25629 | 0 | 0 |
| BELITE BIO INC - ADR | ADR | 07782B104 |  | 370000 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| RECURSION PHARMACEUTICALS-A | Common Stock | 75629V104 |  | 365522 | 74902 | SH |  | SOLE |  | 74902 | 0 | 0 |
| VF CORP | Common Stock | 918204108 |  | 359394 | 24906 | SH |  | SOLE |  | 24906 | 0 | 0 |
| COGENT BIOSCIENCES INC | Common Stock | 19240Q201 |  | 351633 | 24487 | SH |  | SOLE |  | 24487 | 0 | 0 |
| ANI PHARMACEUTICALS INC | Common Stock | 00182C103 |  | 348263 | 3802 | SH |  | SOLE |  | 3802 | 0 | 0 |
| SAREPTA THERAPEUTICS INC | Common Stock | 803607100 |  | 330057 | 17128 | SH |  | SOLE |  | 17128 | 0 | 0 |
| VERA THERAPEUTICS INC | Common Stock | 92337R101 |  | 325094 | 11187 | SH |  | SOLE |  | 11187 | 0 | 0 |
| ORIC PHARMACEUTICALS INC | Common Stock | 68622P109 |  | 324288 | 27024 | SH |  | SOLE |  | 27024 | 0 | 0 |
| NATERA INC | Common Stock | 632307104 |  | 321940 | 2000 | SH |  | SOLE |  | 2000 | 0 | 0 |
| APOGEE THERAPEUTICS INC | Common Stock | 03770N101 |  | 321098 | 8082 | SH |  | SOLE |  | 8082 | 0 | 0 |
| DYNE THERAPEUTICS INC | Common Stock | 26818M108 |  | 315453 | 24937 | SH |  | SOLE |  | 24937 | 0 | 0 |
| EYEPOINT PHARMACEUTICALS INC | Common Stock | 30233G209 |  | 314448 | 22082 | SH |  | SOLE |  | 22082 | 0 | 0 |
| HARROW INC | Common Stock | 415858109 |  | 312495 | 6486 | SH |  | SOLE |  | 6486 | 0 | 0 |
| VNET GROUP INC-ADR | ADR | 90138A103 |  | 309900 | 30000 | SH |  | SOLE |  | 30000 | 0 | 0 |
| ANAPTYSBIO INC | Common Stock | 032724106 |  | 303352 | 9907 | SH |  | SOLE |  | 9907 | 0 | 0 |
| BIOHAVEN LTD | Common Stock | G1110E107 |  | 300200 | 20000 | SH |  | SOLE |  | 20000 | 0 | 0 |
| EDGEWISE THERAPEUTICS INC | Common Stock | 28036F105 |  | 299519 | 18466 | SH |  | SOLE |  | 18466 | 0 | 0 |
| TWIST BIOSCIENCE CORP | Common Stock | 90184D100 |  | 297721 | 10580 | SH |  | SOLE |  | 10580 | 0 | 0 |
| KINIKSA PHARMACEUTICALS INTE | Common Stock | G52694109 |  | 295885 | 7620 | SH |  | SOLE |  | 7620 | 0 | 0 |
| ZOETIS INC | Common Stock | 98978V103 |  | 292640 | 2000 | SH |  | SOLE |  | 2000 | 0 | 0 |
| STRUCTURE THERAPEUTICS INC | ADR | 86366E106 |  | 292432 | 10444 | SH |  | SOLE |  | 10444 | 0 | 0 |
| MANNKIND CORP | Common Stock | 56400P706 |  | 288809 | 53782 | SH |  | SOLE |  | 53782 | 0 | 0 |
| GLOBUS MEDICAL INC - A | Common Stock | 379577208 |  | 286350 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| PROCEPT BIOROBOTICS CORP | Common Stock | 74276L105 |  | 285520 | 8000 | SH |  | SOLE |  | 8000 | 0 | 0 |
| ZAI LAB LTD-ADR | ADR | 98887Q104 |  | 283998 | 8380 | SH |  | SOLE |  | 8380 | 0 | 0 |
| BIOCRYST PHARMACEUTICALS INC | Common Stock | 09058V103 |  | 279282 | 36796 | SH |  | SOLE |  | 36796 | 0 | 0 |
| VERICEL CORP | Common Stock | 92346J108 |  | 278352 | 8845 | SH |  | SOLE |  | 8845 | 0 | 0 |
| HARMONY BIOSCIENCES HOLDINGS | Common Stock | 413197104 |  | 277943 | 10085 | SH |  | SOLE |  | 10085 | 0 | 0 |
| IRHYTHM TECHNOLOGIES INC | Common Stock | 450056106 |  | 275184 | 1600 | SH |  | SOLE |  | 1600 | 0 | 0 |
| HILTON WORLDWIDE HOLDINGS IN | Common Stock | 43300A203 |  | 264888 | 1021 | SH |  | SOLE |  | 1021 | 0 | 0 |
| ABCELLERA BIOLOGICS INC | Common Stock | 00288U106 |  | 263476 | 52381 | SH |  | SOLE |  | 52381 | 0 | 0 |
| DESIGN THERAPEUTICS INC | Common Stock | 25056L103 |  | 263414 | 34982 | SH |  | SOLE |  | 34982 | 0 | 0 |
| HUMANA INC | Common Stock | 444859102 |  | 260967 | 1000 | SH |  | SOLE |  | 1000 | 0 | 0 |
| AVADEL PHARMACEUTICALS | Common Stock | G29687103 |  | 259895 | 17020 | SH |  | SOLE |  | 17020 | 0 | 0 |
| GSK PLC-SPON ADR | ADR | 37733W204 |  | 259102 | 6000 | SH |  | SOLE |  | 6000 | 0 | 0 |
| JANUX THERAPEUTICS INC | Common Stock | 47103J105 |  | 257451 | 10534 | SH |  | SOLE |  | 10534 | 0 | 0 |
| IMMUNOCORE HOLDINGS PLC-ADR | ADR | 45258D105 |  | 255073 | 7021 | SH |  | SOLE |  | 7021 | 0 | 0 |
| AURINIA PHARMACEUTICALS INC | Common Stock | 05156V102 |  | 254957 | 23073 | SH |  | SOLE |  | 23073 | 0 | 0 |
| NOVOCURE LTD | Common Stock | G6674U108 |  | 253193 | 19597 | SH |  | SOLE |  | 19597 | 0 | 0 |
| AUTOLIV INC | Common Stock | 052800109 |  | 247000 | 2000 | SH |  | SOLE |  | 2000 | 0 | 0 |
| NOVAVAX INC | Common Stock | 670002401 |  | 246835 | 28470 | SH |  | SOLE |  | 28470 | 0 | 0 |
| 10X GENOMICS INC-CLASS A | Common Stock | 88025U109 |  | 234443 | 20055 | SH |  | SOLE |  | 20055 | 0 | 0 |
| XPENG INC - ADR | ADR | 98422D105 |  | 234200 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| ARDELYX INC | Common Stock | 039697107 |  | 232748 | 42241 | SH |  | SOLE |  | 42241 | 0 | 0 |
| SYNDAX PHARMACEUTICALS INC | Common Stock | 87164F105 |  | 232298 | 15099 | SH |  | SOLE |  | 15099 | 0 | 0 |
| XERIS BIOPHARMA HOLDINGS INC | Common Stock | 98422E103 |  | 230403 | 28305 | SH |  | SOLE |  | 28305 | 0 | 0 |
| MONTE ROSA THERAPEUTICS INC | Common Stock | 61225M102 |  | 228413 | 30825 | SH |  | SOLE |  | 30825 | 0 | 0 |
| STOKE THERAPEUTICS INC | Common Stock | 86150R107 |  | 225718 | 9605 | SH |  | SOLE |  | 9605 | 0 | 0 |
| GENMAB A/S -SP ADR | ADR | 372303206 |  | 225425 | 7350 | SH |  | SOLE |  | 7350 | 0 | 0 |
| ZYMEWORKS INC | Common Stock | 98985Y108 |  | 225046 | 13176 | SH |  | SOLE |  | 13176 | 0 | 0 |
| RAPPORT THERAPEUTICS INC | Common Stock | 75383L102 |  | 219721 | 7398 | SH |  | SOLE |  | 7398 | 0 | 0 |
| AMPHASTAR PHARMACEUTICALS IN | Common Stock | 03209R103 |  | 217198 | 8150 | SH |  | SOLE |  | 8150 | 0 | 0 |
| TOURMALINE BIO INC | Common Stock | 89157D105 |  | 215378 | 4503 | SH |  | SOLE |  | 4503 | 0 | 0 |
| GRIFOLS SA-ADR | ADR | 398438408 |  | 212985 | 21384 | SH |  | SOLE |  | 21384 | 0 | 0 |
| CUREVAC NV | Common Stock | N2451R105 |  | 212722 | 39466 | SH |  | SOLE |  | 39466 | 0 | 0 |
| ENLIVEN THERAPEUTICS INC | Common Stock | 29337E102 |  | 212540 | 10383 | SH |  | SOLE |  | 10383 | 0 | 0 |
| AMYLYX PHARMACEUTICALS INC | Common Stock | 03237H101 |  | 212412 | 15630 | SH |  | SOLE |  | 15630 | 0 | 0 |
| DYNAVAX TECHNOLOGIES CORP | Common Stock | 268158201 |  | 204111 | 20555 | SH |  | SOLE |  | 20555 | 0 | 0 |
| PACIRA BIOSCIENCES INC | Common Stock | 695127100 |  | 202965 | 7876 | SH |  | SOLE |  | 7876 | 0 | 0 |
| INNOVIVA INC | Common Stock | 45781M101 |  | 201608 | 11047 | SH |  | SOLE |  | 11047 | 0 | 0 |
| PRAXIS PRECISION MEDICINES I | Common Stock | 74006W207 |  | 195517 | 3689 | SH |  | SOLE |  | 3689 | 0 | 0 |
| TREVI THERAPEUTICS INC | Common Stock | 89532M101 |  | 195316 | 21346 | SH |  | SOLE |  | 21346 | 0 | 0 |
| COLLEGIUM PHARMACEUTICAL INC | Common Stock | 19459J104 |  | 193215 | 5522 | SH |  | SOLE |  | 5522 | 0 | 0 |
| NIO INC - ADR | ADR | 62914V106 |  | 190500 | 25000 | SH |  | SOLE |  | 25000 | 0 | 0 |
| SPYRE THERAPEUTICS INC | Common Stock | 00773J202 |  | 177438 | 10587 | SH |  | SOLE |  | 10587 | 0 | 0 |
| ARS PHARMACEUTICALS INC | Common Stock | 82835W108 |  | 174096 | 17323 | SH |  | SOLE |  | 17323 | 0 | 0 |
| PRECIGEN INC | Common Stock | 74017N105 |  | 171837 | 52230 | SH |  | SOLE |  | 52230 | 0 | 0 |
| PRIME MEDICINE INC | Common Stock | 74168J101 |  | 169801 | 30650 | SH |  | SOLE |  | 30650 | 0 | 0 |
| TANGO THERAPEUTICS INC | Common Stock | 87583X109 |  | 163817 | 19502 | SH |  | SOLE |  | 19502 | 0 | 0 |
| UROGEN PHARMA LTD | Common Stock | M96088105 |  | 161775 | 8109 | SH |  | SOLE |  | 8109 | 0 | 0 |
| SANA BIOTECHNOLOGY INC | Common Stock | 799566104 |  | 160982 | 45347 | SH |  | SOLE |  | 45347 | 0 | 0 |
| RELAY THERAPEUTICS INC | Common Stock | 75943R102 |  | 157754 | 30221 | SH |  | SOLE |  | 30221 | 0 | 0 |
| MIND MEDICINE MINDMED INC | Common Stock | 60255C885 |  | 157243 | 13337 | SH |  | SOLE |  | 13337 | 0 | 0 |
| TAYSHA GENE THERAPIES INC | Common Stock | 877619106 |  | 156362 | 47817 | SH |  | SOLE |  | 47817 | 0 | 0 |
| GERON CORP | Common Stock | 374163103 |  | 153214 | 111835 | SH |  | SOLE |  | 111835 | 0 | 0 |
| ARBUTUS BIOPHARMA CORP | Common Stock | 03879J100 |  | 152553 | 33602 | SH |  | SOLE |  | 33602 | 0 | 0 |
| CORMEDIX INC | Common Stock | 21900C308 |  | 152179 | 13085 | SH |  | SOLE |  | 13085 | 0 | 0 |
| SIONNA THERAPEUTICS INC | Common Stock | 829401108 |  | 147050 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| XENCOR INC | Common Stock | 98401F105 |  | 146648 | 12502 | SH |  | SOLE |  | 12502 | 0 | 0 |
| PHATHOM PHARMACEUTICALS INC | Common Stock | 71722W107 |  | 146360 | 12435 | SH |  | SOLE |  | 12435 | 0 | 0 |
| PHIBRO ANIMAL HEALTH CORP-A | Common Stock | 71742Q106 |  | 144442 | 3570 | SH |  | SOLE |  | 3570 | 0 | 0 |
| ARCTURUS THERAPEUTICS HOLDIN | Common Stock | 03969T109 |  | 143017 | 7760 | SH |  | SOLE |  | 7760 | 0 | 0 |
| VIR BIOTECHNOLOGY INC | Common Stock | 92764N102 |  | 139039 | 24350 | SH |  | SOLE |  | 24350 | 0 | 0 |
| IOVANCE BIOTHERAPEUTICS INC | Common Stock | 462260100 |  | 137639 | 63428 | SH |  | SOLE |  | 63428 | 0 | 0 |
| KURA ONCOLOGY INC | Common Stock | 50127T109 |  | 134644 | 15214 | SH |  | SOLE |  | 15214 | 0 | 0 |
| FORTREA HOLDINGS INC | Common Stock | 34965K107 |  | 134013 | 15916 | SH |  | SOLE |  | 15916 | 0 | 0 |
| ANAVEX LIFE SCIENCES CORP | Common Stock | 032797300 |  | 133998 | 15056 | SH |  | SOLE |  | 15056 | 0 | 0 |
| ABRDN PHYSICAL SILVER SHARES | ETP | 003264108 |  | 133440 | 3000 | SH |  | SOLE |  | 3000 | 0 | 0 |
| MESOBLAST LTD- SPON ADR | ADR | 590717401 |  | 133326 | 8276 | SH |  | SOLE |  | 8276 | 0 | 0 |
| ARRIVENT BIOPHARMA INC | Common Stock | 04272N102 |  | 131198 | 7111 | SH |  | SOLE |  | 7111 | 0 | 0 |
| TYRA BIOSCIENCES INC | Common Stock | 90240B106 |  | 130695 | 9342 | SH |  | SOLE |  | 9342 | 0 | 0 |
| THERAVANCE BIOPHARMA INC | Common Stock | G8807B106 |  | 128889 | 8828 | SH |  | SOLE |  | 8828 | 0 | 0 |
| DAY ONE BIOPHARMACEUTICALS I | Common Stock | 23954D109 |  | 126583 | 17955 | SH |  | SOLE |  | 17955 | 0 | 0 |
| ORUKA THERAPEUTICS INC | Common Stock | 687604108 |  | 126245 | 6565 | SH |  | SOLE |  | 6565 | 0 | 0 |
| NURIX THERAPEUTICS INC | Common Stock | 67080M103 |  | 123816 | 13400 | SH |  | SOLE |  | 13400 | 0 | 0 |
| AQUESTIVE THERAPEUTICS INC | Common Stock | 03843E104 |  | 118536 | 21205 | SH |  | SOLE |  | 21205 | 0 | 0 |
| OLEMA PHARMACEUTICALS INC | Common Stock | 68062P106 |  | 117783 | 12031 | SH |  | SOLE |  | 12031 | 0 | 0 |
| MEIRAGTX HOLDINGS PLC | Common Stock | G59665102 |  | 116051 | 14101 | SH |  | SOLE |  | 14101 | 0 | 0 |
| CASTLE BIOSCIENCES INC | Common Stock | 14843C105 |  | 115785 | 5085 | SH |  | SOLE |  | 5085 | 0 | 0 |
| TERNS PHARMACEUTICALS INC | Common Stock | 880881107 |  | 115196 | 15339 | SH |  | SOLE |  | 15339 | 0 | 0 |
| SIGA TECHNOLOGIES INC | Common Stock | 826917106 |  | 114842 | 12551 | SH |  | SOLE |  | 12551 | 0 | 0 |
| KEROS THERAPEUTICS INC | Common Stock | 492327101 |  | 112623 | 7119 | SH |  | SOLE |  | 7119 | 0 | 0 |
| TRANSMEDICS GROUP INC | Common Stock | 89377M109 |  | 112200 | 1000 | SH |  | SOLE |  | 1000 | 0 | 0 |
| ARVINAS INC | Common Stock | 04335A105 |  | 109644 | 12869 | SH |  | SOLE |  | 12869 | 0 | 0 |
| ERASCA INC | Common Stock | 29479A108 |  | 108396 | 49723 | SH |  | SOLE |  | 49723 | 0 | 0 |
| SAVARA INC | Common Stock | 805111101 |  | 108157 | 30296 | SH |  | SOLE |  | 30296 | 0 | 0 |
| TECTONIC THERAPEUTIC INC | Common Stock | 878972108 |  | 107947 | 6880 | SH |  | SOLE |  | 6880 | 0 | 0 |
| ANNEXON INC | Common Stock | 03589W102 |  | 107546 | 35261 | SH |  | SOLE |  | 35261 | 0 | 0 |
| KALVISTA PHARMACEUTICALS INC | Common Stock | 483497103 |  | 107476 | 8824 | SH |  | SOLE |  | 8824 | 0 | 0 |
| ENANTA PHARMACEUTICALS INC | Common Stock | 29251M106 |  | 104702 | 8747 | SH |  | SOLE |  | 8747 | 0 | 0 |
| PERSONALIS INC | Common Stock | 71535D106 |  | 101347 | 15544 | SH |  | SOLE |  | 15544 | 0 | 0 |
| TANDEM DIABETES CARE INC | Common Stock | 875372203 |  | 97120 | 8000 | SH |  | SOLE |  | 8000 | 0 | 0 |
| CORVUS PHARMACEUTICALS INC | Common Stock | 221015100 |  | 96260 | 13061 | SH |  | SOLE |  | 13061 | 0 | 0 |
| REZOLUTE INC | Common Stock | 76200L309 |  | 94000 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| ESPERION THERAPEUTICS INC | Common Stock | 29664W105 |  | 93654 | 35341 | SH |  | SOLE |  | 35341 | 0 | 0 |
| ZEVRA THERAPEUTICS INC | Common Stock | 488445206 |  | 93578 | 9840 | SH |  | SOLE |  | 9840 | 0 | 0 |
| COMPASS PATHWAYS PLC | ADR | 20451W101 |  | 92115 | 16076 | SH |  | SOLE |  | 16076 | 0 | 0 |
| PROTHENA CORP PLC | Common Stock | G72800108 |  | 92095 | 9436 | SH |  | SOLE |  | 9436 | 0 | 0 |
| OMEROS CORP | Common Stock | 682143102 |  | 89909 | 21929 | SH |  | SOLE |  | 21929 | 0 | 0 |
| RIGEL PHARMACEUTICALS INC | Common Stock | 766559702 |  | 89070 | 3144 | SH |  | SOLE |  | 3144 | 0 | 0 |
| MBX BIOSCIENCES INC | Common Stock | 55287L101 |  | 87500 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| GALAPAGOS NV-SPON ADR | ADR | 36315X101 |  | 86981 | 2511 | SH |  | SOLE |  | 2511 | 0 | 0 |
| LEXICON PHARMACEUTICALS INC | Common Stock | 528872302 |  | 85992 | 63698 | SH |  | SOLE |  | 63698 | 0 | 0 |
| HUTCHMED CHINA-ADR | ADR | 44842L103 |  | 85633 | 5437 | SH |  | SOLE |  | 5437 | 0 | 0 |
| INHIBRX BIOSCIENCES INC | Common Stock | 45720N103 |  | 85514 | 2539 | SH |  | SOLE |  | 2539 | 0 | 0 |
| REGENXBIO INC | Common Stock | 75901B107 |  | 85441 | 8854 | SH |  | SOLE |  | 8854 | 0 | 0 |
| SOLID BIOSCIENCES INC | Common Stock | 83422E204 |  | 84214 | 13649 | SH |  | SOLE |  | 13649 | 0 | 0 |
| CHINA YUCHAI INTL LTD | Common Stock | G21082105 |  | 82740 | 2000 | SH |  | SOLE |  | 2000 | 0 | 0 |
| ABSCI CORP | Common Stock | 00091E109 |  | 79675 | 26209 | SH |  | SOLE |  | 26209 | 0 | 0 |
| PHARVARIS NV | Common Stock | N69605108 |  | 74850 | 3000 | SH |  | SOLE |  | 3000 | 0 | 0 |
| MARAVAI LIFESCIENCES HLDGS-A | Common Stock | 56600D107 |  | 72783 | 25360 | SH |  | SOLE |  | 25360 | 0 | 0 |
| ALPHATEC HOLDINGS INC | Common Stock | 02081G201 |  | 72700 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| ASTRIA THERAPEUTICS INC | Common Stock | 04635X102 |  | 72014 | 9892 | SH |  | SOLE |  | 9892 | 0 | 0 |
| 4D MOLECULAR THERAPEUTICS IN | Common Stock | 35104E100 |  | 71136 | 8186 | SH |  | SOLE |  | 8186 | 0 | 0 |
| EVOLUS INC | Common Stock | 30052C107 |  | 69615 | 11338 | SH |  | SOLE |  | 11338 | 0 | 0 |
| ALUMIS INC | Common Stock | 022307102 |  | 67758 | 16982 | SH |  | SOLE |  | 16982 | 0 | 0 |
| PACIFIC BIOSCIENCES OF CALIF | Common Stock | 69404D108 |  | 67392 | 52650 | SH |  | SOLE |  | 52650 | 0 | 0 |
| AURA BIOSCIENCES INC | Common Stock | 05153U107 |  | 67294 | 10889 | SH |  | SOLE |  | 10889 | 0 | 0 |
| LEXEO THERAPEUTICS INC | Common Stock | 52886X107 |  | 62854 | 9466 | SH |  | SOLE |  | 9466 | 0 | 0 |
| BICYCLE THERAPEUTICS PLC-ADR | ADR | 088786108 |  | 62725 | 8104 | SH |  | SOLE |  | 8104 | 0 | 0 |
| ROCKET PHARMACEUTICALS INC | Common Stock | 77313F106 |  | 61660 | 18914 | SH |  | SOLE |  | 18914 | 0 | 0 |
| CULLINAN THERAPEUTICS INC | Common Stock | 230031106 |  | 61405 | 10355 | SH |  | SOLE |  | 10355 | 0 | 0 |
| ALTIMMUNE INC | Common Stock | 02155H200 |  | 58322 | 15470 | SH |  | SOLE |  | 15470 | 0 | 0 |
| ALPHA TEKNOVA INC | Common Stock | 02080L102 |  | 58062 | 9380 | SH |  | SOLE |  | 9380 | 0 | 0 |
| BRIDGEBIO ONCOLOGY THERAPEUT | Common Stock | 107924102 |  | 57900 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| AMARIN CORP PLC -ADR | ADR | 023111404 |  | 57887 | 3534 | SH |  | SOLE |  | 3534 | 0 | 0 |
| REPLIMUNE GROUP INC | Common Stock | 76029N106 |  | 57328 | 13682 | SH |  | SOLE |  | 13682 | 0 | 0 |
| AUTOLUS THERAPEUTICS PLC | ADR | 05280R100 |  | 57306 | 35157 | SH |  | SOLE |  | 35157 | 0 | 0 |
| EDITAS MEDICINE INC | Common Stock | 28106W103 |  | 54694 | 15762 | SH |  | SOLE |  | 15762 | 0 | 0 |
| LYELL IMMUNOPHARMA INC | Common Stock | 55083R203 |  | 54680 | 3367 | SH |  | SOLE |  | 3367 | 0 | 0 |
| SCPHARMACEUTICALS INC | Common Stock | 810648105 |  | 52969 | 9342 | SH |  | SOLE |  | 9342 | 0 | 0 |
| ALECTOR INC | Common Stock | 014442107 |  | 52513 | 17741 | SH |  | SOLE |  | 17741 | 0 | 0 |
| MAZE THERAPEUTICS INC | Common Stock | 578784100 |  | 51860 | 2000 | SH |  | SOLE |  | 2000 | 0 | 0 |
| VANDA PHARMACEUTICALS INC | Common Stock | 921659108 |  | 51681 | 10357 | SH |  | SOLE |  | 10357 | 0 | 0 |
| NEUMORA THERAPEUTICS INC | Common Stock | 640979100 |  | 51664 | 28387 | SH |  | SOLE |  | 28387 | 0 | 0 |
| AC IMMUNE SA | Common Stock | H00263105 |  | 50864 | 17600 | SH |  | SOLE |  | 17600 | 0 | 0 |
| LARIMAR THERAPEUTICS INC | Common Stock | 517125100 |  | 48460 | 15003 | SH |  | SOLE |  | 15003 | 0 | 0 |
| FOGHORN THERAPEUTICS INC | Common Stock | 344174107 |  | 48455 | 9909 | SH |  | SOLE |  | 9909 | 0 | 0 |
| HUMACYTE INC | Common Stock | 44486Q103 |  | 48302 | 27760 | SH |  | SOLE |  | 27760 | 0 | 0 |
| ALLOGENE THERAPEUTICS INC | Common Stock | 019770106 |  | 48226 | 38892 | SH |  | SOLE |  | 38892 | 0 | 0 |
| KESTRA MEDICAL TECHNOLOGIES | Common Stock | G52441105 |  | 47520 | 2000 | SH |  | SOLE |  | 2000 | 0 | 0 |
| CARTESIAN THERAPEUTICS INC | Common Stock | 816212302 |  | 46583 | 4558 | SH |  | SOLE |  | 4558 | 0 | 0 |
| KYVERNA THERAPEUTICS INC | Common Stock | 501976104 |  | 45480 | 7580 | SH |  | SOLE |  | 7580 | 0 | 0 |
| VOYAGER THERAPEUTICS INC | Common Stock | 92915B106 |  | 45406 | 9723 | SH |  | SOLE |  | 9723 | 0 | 0 |
| NEUROGENE INC | Common Stock | 64135M105 |  | 43360 | 2502 | SH |  | SOLE |  | 2502 | 0 | 0 |
| SILENCE THERAPEUTICS PLC-ADR | ADR | 82686Q101 |  | 42724 | 8232 | SH |  | SOLE |  | 8232 | 0 | 0 |
| ATEA PHARMACEUTICALS INC | Common Stock | 04683R106 |  | 40339 | 13910 | SH |  | SOLE |  | 13910 | 0 | 0 |
| TVARDI THERAPEUTICS INC | Common Stock | 140755307 |  | 38970 | 1000 | SH |  | SOLE |  | 1000 | 0 | 0 |
| ENTRADA THERAPEUTICS INC | Common Stock | 29384C108 |  | 38669 | 6667 | SH |  | SOLE |  | 6667 | 0 | 0 |
| CODEXIS INC | Common Stock | 192005106 |  | 38608 | 15823 | SH |  | SOLE |  | 15823 | 0 | 0 |
| IRONWOOD PHARMACEUTICALS INC | Common Stock | 46333X108 |  | 37298 | 28472 | SH |  | SOLE |  | 28472 | 0 | 0 |
| IMMUNEERING CORP - CLASS A | Common Stock | 45254E107 |  | 35000 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| OMNIAB INC | Common Stock | 68218J103 |  | 34413 | 21508 | SH |  | SOLE |  | 21508 | 0 | 0 |
| MAXCYTE INC | Common Stock | 57777K106 |  | 29525 | 18687 | SH |  | SOLE |  | 18687 | 0 | 0 |
| C4 THERAPEUTICS INC | Common Stock | 12529R107 |  | 27695 | 12475 | SH |  | SOLE |  | 12475 | 0 | 0 |
| TEVOGEN BIO HOLDINGS INC | Common Stock | 88165K101 |  | 27076 | 34479 | SH |  | SOLE |  | 34479 | 0 | 0 |
| PEPGEN INC | Common Stock | 713317105 |  | 26560 | 5749 | SH |  | SOLE |  | 5749 | 0 | 0 |
| BURNING ROCK BIOTECH LTD-ADR | ADR | 12233L206 |  | 25950 | 3000 | SH |  | SOLE |  | 3000 | 0 | 0 |
| NKARTA INC | Common Stock | 65487U108 |  | 25772 | 12450 | SH |  | SOLE |  | 12450 | 0 | 0 |
| FATE THERAPEUTICS INC | Common Stock | 31189P102 |  | 25472 | 20216 | SH |  | SOLE |  | 20216 | 0 | 0 |
| PYXIS ONCOLOGY INC | Common Stock | 747324101 |  | 24134 | 10871 | SH |  | SOLE |  | 10871 | 0 | 0 |
| CLIMB BIO INC | Common Stock | 28658R106 |  | 23875 | 11878 | SH |  | SOLE |  | 11878 | 0 | 0 |
| BIOMEA FUSION INC | Common Stock | 09077A106 |  | 21071 | 10431 | SH |  | SOLE |  | 10431 | 0 | 0 |
| AMN HEALTHCARE SERVICES INC | Common Stock | 001744101 |  | 19360 | 1000 | SH |  | SOLE |  | 1000 | 0 | 0 |
| MACROGENICS INC | Common Stock | 556099109 |  | 18613 | 11079 | SH |  | SOLE |  | 11079 | 0 | 0 |
| OCULIS HOLDING AG | Common Stock | H5870P102 |  | 17580 | 1000 | SH |  | SOLE |  | 1000 | 0 | 0 |
| TSCAN THERAPEUTICS INC | Common Stock | 89854M101 |  | 16739 | 9197 | SH |  | SOLE |  | 9197 | 0 | 0 |
| ALIGN TECHNOLOGY INC | Common Stock | 016255101 |  | 16654 | 133 | SH |  | SOLE |  | 133 | 0 | 0 |
| PLIANT THERAPEUTICS INC | Common Stock | 729139105 |  | 15925 | 10760 | SH |  | SOLE |  | 10760 | 0 | 0 |
| APPLIED THERAPEUTICS INC | Common Stock | 03828A101 |  | 15269 | 25243 | SH |  | SOLE |  | 25243 | 0 | 0 |
| CROSS COUNTRY HEALTHCARE INC | Common Stock | 227483104 |  | 14200 | 1000 | SH |  | SOLE |  | 1000 | 0 | 0 |
| SUTRO BIOPHARMA INC | Common Stock | 869367102 |  | 12904 | 14860 | SH |  | SOLE |  | 14860 | 0 | 0 |
| SURROZEN INC | Common Stock | 86889P208 |  | 12885 | 1000 | SH |  | SOLE |  | 1000 | 0 | 0 |
| ARTIVA BIOTHERAPEUTICS INC | Common Stock | 04317A107 |  | 12286 | 4281 | SH |  | SOLE |  | 4281 | 0 | 0 |
| ACRIVON THERAPEUTICS INC | Common Stock | 004890109 |  | 9980 | 5514 | SH |  | SOLE |  | 5514 | 0 | 0 |
| MERSANA THERAPEUTICS INC | Common Stock | 59045L205 |  | 6790 | 875 | SH |  | SOLE |  | 875 | 0 | 0 |
| ONKURE THERAPEUTICS INC-A | Common Stock | 68277Q105 |  | 6190 | 2251 | SH |  | SOLE |  | 2251 | 0 | 0 |
| Q32 BIO INC | Common Stock | 746964105 |  | 4233 | 2138 | SH |  | SOLE |  | 2138 | 0 | 0 |
| CHIPOTLE MEXICAN GRILL INC | Common Stock | 169656105 |  | 2391 | 61 | SH |  | SOLE |  | 61 | 0 | 0 |
| WOLFSPEED INC | Common Stock | 97785W106 |  | 2374 | 83 | SH |  | SOLE |  | 83 | 0 | 0 |
| HERSHEY CO/THE | Common Stock | 427866108 |  | 1871 | 10 | SH |  | SOLE |  | 10 | 0 | 0 |
| SPDR S 500 ETF TRUST | ETP | 78462F103 |  | 298 | 0 | SH |  | SOLE |  | 0 | 0 | 0 |

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