# EDGAR Filing Document

**Accession Number:** 0000836487
**File Stem:** 0001104659-26-022139
**Filing Date:** 2026-3
**Character Count:** 19429
**Document Hash:** b5d86dfd37cbb57fcc7c610c7094677d
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-26-022139.hdr.sgml**: 20260302

**ACCESSION NUMBER**: 0001104659-26-022139

**CONFORMED SUBMISSION TYPE**: 497

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20260302

**DATE AS OF CHANGE**: 20260302

**EFFECTIVENESS DATE**: 20260302

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** MORGAN STANLEY INSTITUTIONAL FUND INC
- **CENTRAL INDEX KEY:** 0000836487

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** MD
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 497
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 033-23166
- **FILM NUMBER:** 26706603

**BUSINESS ADDRESS:**
- **STREET 1:** 1585 BROADWAY
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10036
- **BUSINESS PHONE:** 800-548-7786

**MAIL ADDRESS:**
- **STREET 1:** 1585 BROADWAY
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10036

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** MORGAN STANLEY DEAN WITTER INSTITUTIONAL FUND INC
- **DATE OF NAME CHANGE:** 19990329

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** MORGAN STANLEY INSTITUTIONAL FUND INC
- **DATE OF NAME CHANGE:** 19920703

## Series and Classes Contracts Data

### Passport Overseas Equity Portfolio (Series ID: S000002820)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| CLASS I    | MSACX         | C000007736 |
| CLASS A    | MSIBX         | C000007737 |
| Class L    | MSLLX         | C000113799 |
| Class C    | MSAAX         | C000155887 |
| Class R6   | MAIJX         | C000215548 |
| Class IR   | MAIHX         | C000215549 |

---

### Inception Portfolio (Series ID: S000002825)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| CLASS I    | MSSGX         | C000007744 |
| CLASS A    | MSSMX         | C000007745 |
| Class L    | MSSLX         | C000104303 |
| Class R6   | MFLLX         | C000129402 |
| Class C    | MSCOX         | C000155889 |

---

### EMERGING MARKETS PORTFOLIO (Series ID: S000002826)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| CLASS I    | MGEMX         | C000007746 |
| CLASS A    | MMKBX         | C000007747 |
| Class L    | MSELX         | C000113803 |
| Class R6   | MMMPX         | C000126912 |
| Class C    | MSEPX         | C000155890 |
| Class IR   | MRGEX         | C000198815 |

---

### GROWTH PORTFOLIO (Series ID: S000002828)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| CLASS I    | MSEQX         | C000007750 |
| CLASS A    | MSEGX         | C000007751 |
| Class L    | MSHLX         | C000113805 |
| Class R6   | MGRPX         | C000126914 |
| Class C    | MSGUX         | C000155892 |
| Class IR   | MGHRX         | C000198816 |

---

### GLOBAL FRANCHISE PORTFOLIO (Series ID: S000002830)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| CLASS I    | MSFAX         | C000007754 |
| CLASS A    | MSFBX         | C000007755 |
| Class L    | MSFLX         | C000113809 |
| Class C    | MSGFX         | C000155893 |
| Class R6   | MGISX         | C000156276 |

---

### INTERNATIONAL EQUITY PORTFOLIO (Series ID: S000002832)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| CLASS I    | MSIQX         | C000007758 |
| CLASS A    | MIQBX         | C000007759 |
| Class L    | MSQLX         | C000113811 |
| Class R6   | MIQPX         | C000126915 |
| Class C    | MSECX         | C000155894 |

---

### International Opportunity Portfolio (Series ID: S000027992)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| Class I    | MIOIX         | C000085087 |
| Class L    | MIOLX         | C000085088 |
| Class A    | MIOPX         | C000085089 |
| Class R6   | MNOPX         | C000126918 |
| Class C    | MSOCX         | C000155897 |
| Class IR   | MRNPX         | C000198820 |

---

### Advantage Portfolio (Series ID: S000027993)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| Class I    | MPAIX         | C000085091 |
| Class L    | MAPLX         | C000085092 |
| Class A    | MAPPX         | C000085093 |
| Class R6   | MADSX         | C000126919 |
| Class C    | MSPRX         | C000155898 |

---

### Global Opportunity Portfolio (Series ID: S000027995)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| Class I    | MGGIX         | C000085098 |
| Class L    | MGGLX         | C000085099 |
| Class A    | MGGPX         | C000085100 |
| Class R6   | MGTSX         | C000126921 |
| Class C    | MSOPX         | C000155900 |
| Class IR   | MGORX         | C000198822 |

---

### Global Insight Portfolio (Series ID: S000030616)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| Class I    | MIGIX         | C000094891 |
| Class L    | MIGLX         | C000094892 |
| Class A    | MIGPX         | C000094893 |
| Class C    | MSPTX         | C000155902 |
| Class R6   | MGZZX         | C000228507 |

---

### International Advantage Portfolio (Series ID: S000030618)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| Class I    | MFAIX         | C000094898 |
| Class L    | MSALX         | C000094899 |
| Class A    | MFAPX         | C000094900 |
| Class C    | MSIAX         | C000155904 |
| Class R6   | IDVSX         | C000198826 |

---

### Global Stars Portfolio (Series ID: S000041864)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| Class I    | MGQIX         | C000129960 |
| Class A    | MGQAX         | C000129961 |
| Class L    | MGQLX         | C000129962 |
| Class R6   | MGQSX         | C000129963 |
| Class C    | MSGQX         | C000155911 |

---

### Emerging Markets Leaders Portfolio (Series ID: S000047473)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| Class I    | MELIX         | C000149047 |
| Class A    | MELAX         | C000149048 |
| Class R6   | MELSX         | C000149050 |
| Class C    | MEMLX         | C000155912 |
| Class IR   | MSIWX         | C000226932 |

---

### Asia Opportunity Portfolio (Series ID: S000051832)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| Class I    | MSAQX         | C000163120 |
| Class A    | MSAUX         | C000163121 |
| Class C    | MSAWX         | C000163122 |
| Class R6   | MSAYX         | C000163123 |

---

### Global Concentrated Portfolio (Series ID: S000053786)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| Class I    | MLNIX         | C000169208 |
| Class A    | MLNAX         | C000169209 |
| Class C    | MLNCX         | C000169210 |
| Class R6   | MLNSX         | C000169211 |

---

### Global Core Portfolio (Series ID: S000053787)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| Class I    | MLMIX         | C000169212 |
| Class A    | MLMAX         | C000169213 |
| Class C    | MLMCX         | C000169214 |
| Class R6   | MLMSX         | C000169215 |

---

### US Core Portfolio (Series ID: S000053789)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| Class I    | MUOIX         | C000169220 |
| Class A    | MUOAX         | C000169221 |
| Class C    | MUOCX         | C000169222 |
| Class R6   | MUOSX         | C000169223 |

---

### Global Endurance Portfolio (Series ID: S000063049)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| Class R6   | MSJSX         | C000204517 |
| Class A    | MSJAX         | C000204518 |
| Class C    | MSJCX         | C000204519 |
| Class I    | MSJIX         | C000204520 |

---

### Global Permanence Portfolio (Series ID: S000065236)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| Class R6   | MGKQX         | C000211165 |
| Class A    | MGKAX         | C000211166 |
| Class C    | MGKCX         | C000211167 |
| Class I    | MGKIX         | C000211168 |

---

### Developing Opportunity Portfolio (Series ID: S000067259)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| Class I    | MDOEX         | C000216354 |
| Class A    | MDOAX         | C000216355 |
| Class R6   | MDODX         | C000216356 |
| Class C    | MDOBX         | C000216357 |

---

### Permanence Portfolio (Series ID: S000068163)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| Class R6   | MSHPX         | C000218314 |
| Class A    | MSHNX         | C000218315 |
| Class C    | MSHOX         | C000218316 |
| Class I    | MSHMX         | C000218317 |

---

### Vitality Portfolio (Series ID: S000074797)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| Class I    | MSVDX         | C000233002 |
| Class A    | MSVEX         | C000233003 |
| Class C    | MSVMX         | C000233004 |
| Class R6   | MSVOX         | C000233005 |

---

### Emerging Markets ex China Portfolio (Series ID: S000076838)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| Class R6   | MSDMX         | C000236911 |
| Class A    | MSDQX         | C000236912 |
| Class C    | MSDOX         | C000236913 |
| Class I    | MSDUX         | C000236914 |

---

### International Resilience Portfolio (Series ID: S000076842)

---

|  |  |  |
|:---|:---|:---|
| Class Name | Ticker Symbol | Class ID   |
| Class I    | MSDKX         | C000236927 |
| Class C    | MSDEX         | C000236928 |
| Class R6   | MSCZX         | C000236929 |
| Class A    | MSDFX         | C000236930 |

---

## Series and Classes Contracts Data

### Passport Overseas Equity Portfolio (Series ID: S000002820)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000007736 | CLASS I      | MSACX           |
| C000007737 | CLASS A      | MSIBX           |
| C000113799 | Class L      | MSLLX           |
| C000155887 | Class C      | MSAAX           |
| C000215548 | Class R6     | MAIJX           |
| C000215549 | Class IR     | MAIHX           |

### Inception Portfolio (Series ID: S000002825)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000007744 | CLASS I      | MSSGX           |
| C000007745 | CLASS A      | MSSMX           |
| C000104303 | Class L      | MSSLX           |
| C000129402 | Class R6     | MFLLX           |
| C000155889 | Class C      | MSCOX           |

### EMERGING MARKETS PORTFOLIO (Series ID: S000002826)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000007746 | CLASS I      | MGEMX           |
| C000007747 | CLASS A      | MMKBX           |
| C000113803 | Class L      | MSELX           |
| C000126912 | Class R6     | MMMPX           |
| C000155890 | Class C      | MSEPX           |
| C000198815 | Class IR     | MRGEX           |

### GROWTH PORTFOLIO (Series ID: S000002828)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000007750 | CLASS I      | MSEQX           |
| C000007751 | CLASS A      | MSEGX           |
| C000113805 | Class L      | MSHLX           |
| C000126914 | Class R6     | MGRPX           |
| C000155892 | Class C      | MSGUX           |
| C000198816 | Class IR     | MGHRX           |

### GLOBAL FRANCHISE PORTFOLIO (Series ID: S000002830)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000007754 | CLASS I      | MSFAX           |
| C000007755 | CLASS A      | MSFBX           |
| C000113809 | Class L      | MSFLX           |
| C000155893 | Class C      | MSGFX           |
| C000156276 | Class R6     | MGISX           |

### INTERNATIONAL EQUITY PORTFOLIO (Series ID: S000002832)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000007758 | CLASS I      | MSIQX           |
| C000007759 | CLASS A      | MIQBX           |
| C000113811 | Class L      | MSQLX           |
| C000126915 | Class R6     | MIQPX           |
| C000155894 | Class C      | MSECX           |

### International Opportunity Portfolio (Series ID: S000027992)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000085087 | Class I      | MIOIX           |
| C000085088 | Class L      | MIOLX           |
| C000085089 | Class A      | MIOPX           |
| C000126918 | Class R6     | MNOPX           |
| C000155897 | Class C      | MSOCX           |
| C000198820 | Class IR     | MRNPX           |

### Advantage Portfolio (Series ID: S000027993)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000085091 | Class I      | MPAIX           |
| C000085092 | Class L      | MAPLX           |
| C000085093 | Class A      | MAPPX           |
| C000126919 | Class R6     | MADSX           |
| C000155898 | Class C      | MSPRX           |

### Global Opportunity Portfolio (Series ID: S000027995)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000085098 | Class I      | MGGIX           |
| C000085099 | Class L      | MGGLX           |
| C000085100 | Class A      | MGGPX           |
| C000126921 | Class R6     | MGTSX           |
| C000155900 | Class C      | MSOPX           |
| C000198822 | Class IR     | MGORX           |

### Global Insight Portfolio (Series ID: S000030616)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000094891 | Class I      | MIGIX           |
| C000094892 | Class L      | MIGLX           |
| C000094893 | Class A      | MIGPX           |
| C000155902 | Class C      | MSPTX           |
| C000228507 | Class R6     | MGZZX           |

### International Advantage Portfolio (Series ID: S000030618)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000094898 | Class I      | MFAIX           |
| C000094899 | Class L      | MSALX           |
| C000094900 | Class A      | MFAPX           |
| C000155904 | Class C      | MSIAX           |
| C000198826 | Class R6     | IDVSX           |

### Global Stars Portfolio (Series ID: S000041864)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000129960 | Class I      | MGQIX           |
| C000129961 | Class A      | MGQAX           |
| C000129962 | Class L      | MGQLX           |
| C000129963 | Class R6     | MGQSX           |
| C000155911 | Class C      | MSGQX           |

### Emerging Markets Leaders Portfolio (Series ID: S000047473)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000149047 | Class I      | MELIX           |
| C000149048 | Class A      | MELAX           |
| C000149050 | Class R6     | MELSX           |
| C000155912 | Class C      | MEMLX           |
| C000226932 | Class IR     | MSIWX           |

### Asia Opportunity Portfolio (Series ID: S000051832)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000163120 | Class I      | MSAQX           |
| C000163121 | Class A      | MSAUX           |
| C000163122 | Class C      | MSAWX           |
| C000163123 | Class R6     | MSAYX           |

### Global Concentrated Portfolio (Series ID: S000053786)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000169208 | Class I      | MLNIX           |
| C000169209 | Class A      | MLNAX           |
| C000169210 | Class C      | MLNCX           |
| C000169211 | Class R6     | MLNSX           |

### Global Core Portfolio (Series ID: S000053787)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000169212 | Class I      | MLMIX           |
| C000169213 | Class A      | MLMAX           |
| C000169214 | Class C      | MLMCX           |
| C000169215 | Class R6     | MLMSX           |

### US Core Portfolio (Series ID: S000053789)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000169220 | Class I      | MUOIX           |
| C000169221 | Class A      | MUOAX           |
| C000169222 | Class C      | MUOCX           |
| C000169223 | Class R6     | MUOSX           |

### Global Endurance Portfolio (Series ID: S000063049)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000204517 | Class R6     | MSJSX           |
| C000204518 | Class A      | MSJAX           |
| C000204519 | Class C      | MSJCX           |
| C000204520 | Class I      | MSJIX           |

### Global Permanence Portfolio (Series ID: S000065236)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000211165 | Class R6     | MGKQX           |
| C000211166 | Class A      | MGKAX           |
| C000211167 | Class C      | MGKCX           |
| C000211168 | Class I      | MGKIX           |

### Developing Opportunity Portfolio (Series ID: S000067259)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000216354 | Class I      | MDOEX           |
| C000216355 | Class A      | MDOAX           |
| C000216356 | Class R6     | MDODX           |
| C000216357 | Class C      | MDOBX           |

### Permanence Portfolio (Series ID: S000068163)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000218314 | Class R6     | MSHPX           |
| C000218315 | Class A      | MSHNX           |
| C000218316 | Class C      | MSHOX           |
| C000218317 | Class I      | MSHMX           |

### Vitality Portfolio (Series ID: S000074797)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000233002 | Class I      | MSVDX           |
| C000233003 | Class A      | MSVEX           |
| C000233004 | Class C      | MSVMX           |
| C000233005 | Class R6     | MSVOX           |

### Emerging Markets ex China Portfolio (Series ID: S000076838)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000236911 | Class R6     | MSDMX           |
| C000236912 | Class A      | MSDQX           |
| C000236913 | Class C      | MSDOX           |
| C000236914 | Class I      | MSDUX           |

### International Resilience Portfolio (Series ID: S000076842)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000236927 | Class I      | MSDKX           |
| C000236928 | Class C      | MSDEX           |
| C000236929 | Class R6     | MSCZX           |
| C000236930 | Class A      | MSDFX           |

**Prospectus Supplement**

**March 2, 2026**

Morgan Stanley Institutional Fund, Inc.

Supplement dated March 2, 2026 to the Morgan Stanley Institutional Fund, Inc. Prospectuses dated April 30, 2025, as supplemented

**Advantage Portfolio<br>Asia Opportunity Portfolio<br>Developing Opportunity Portfolio<br>Emerging Markets ex China Portfolio<br>Emerging Markets Leaders Portfolio<br>Emerging Markets Portfolio<br>Global Concentrated Portfolio<br>Global Core Portfolio<br>Global Endurance Portfolio<br>Global Franchise Portfolio<br>Global Insight Portfolio<br>Global Opportunity Portfolio<br>Global Permanence Portfolio<br>Global Stars Portfolio<br>Growth Portfolio<br>Inception Portfolio<br>International Advantage Portfolio<br>International Equity Portfolio<br>International Opportunity Portfolio<br>International Resilience Portfolio<br>Passport Overseas Equity Portfolio<br>Permanence Portfolio<br>US Core Portfolio<br>Vitality Portfolio**

Effective February 27, 2026, shares of the E\*Trade No Fee Index Funds held in Related Accounts (as defined in each Prospectus) are included for purposes of calculating the Class A share right of accumulation, subject to the requirements set forth in each Prospectus.

**Please retain this supplement for future reference.**

&nbsp;&nbsp;&nbsp;&nbsp;IFIROAPROSPT 2/26

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