# EDGAR Filing Document

**Accession Number:** 0001455365
**File Stem:** 0001104659-25-089737
**Filing Date:** 2025-9
**Character Count:** 40536
**Document Hash:** 847ef16a04dac1fa939f27ffc5994031
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-25-089737.hdr.sgml**: 20250915

**ACCESSION NUMBER**: 0001104659-25-089737

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 53

**CONFORMED PERIOD OF REPORT**: 20250915

**ITEM INFORMATION**: Other Events

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20250915

**DATE AS OF CHANGE**: 20250915

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** COGNITION THERAPEUTICS INC
- **CENTRAL INDEX KEY:** 0001455365
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-40886
- **FILM NUMBER:** 251313150

**BUSINESS ADDRESS:**
- **STREET 1:** 2403 SIDNEY STREET
- **STREET 2:** SUITE 261
- **CITY:** PITTSBURGH
- **STATE:** PA
- **ZIP:** 15203
- **BUSINESS PHONE:** 412-481-2210

**MAIL ADDRESS:**
- **STREET 1:** 2500 WESTCHESTER AVE
- **CITY:** PURCHASE
- **STATE:** NY
- **ZIP:** 10577

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** COGNITION THERAPUTICS INC
- **DATE OF NAME CHANGE:** 20090204

?xml version='1.0' encoding='ASCII'?

**UNITED STATES SECURITIES AND EXCHANGE COMMISSION** **Washington, DC 20549**

**FORM 8-K**

**CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934**

Date of Report (Date of earliest event reported): **September 15, 2025**

**Cognition Therapeutics, Inc.**

(Exact name of registrant as specified in its charter)

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| **Delaware** | **001-40886** | **13-4365359** |
| (State or other jurisdiction of<br> incorporation or organization) | (Primary Standard Industrial<br> Classification Code Number) | (I.R.S. Employer<br> Identification No.) |

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| **2500 Westchester Avenue** **<br> Purchase, NY** | **10577** |
| (Address of principal executive offices) | (Zip Code) |

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Registrant's telephone number, including area code: **(412) 481-2210**

**Not Applicable** (Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

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| Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) |
| Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) |
| Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |
| Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |

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Securities registered pursuant to Section 12(b) of the Act:

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| **Title of Each Class** | **Trading Symbol** | **Name of Exchange on Which<br> Registered** |
| Common Stock, par value $0.001 per share | CGTX | The Nasdaq Stock Market LLC |

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Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ⌧

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻

**Item 8.01 Other Events.**

Attached as Exhibit 99.1 is a presentation that the Company may use from time to time in presentations or discussions with investors, analysts, and other parties.

**Item 9.01 Financial Statements and Exhibits.**

(d) Exhibits

The following exhibits are being furnished herewith:

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| **Exhibit<br> No.** | **Document** |
| [99.1](tm2525997d1_ex99-1.htm) | [Investor presentation of Cognition Therapeutics, Inc.](tm2525997d1_ex99-1.htm) |
| 104 | Cover Page Interactive Data File (embedded within the Inline XBRL document) |

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**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

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|  | **COGNITION THERAPEUTICS, INC.** | **COGNITION THERAPEUTICS, INC.** |
| Date: September 15, 2025 |  |  |
|  | By: | */s/ Lisa Ricciardi* |
|  | Name: | Lisa Ricciardi |
|  | Title: | President and Chief Executive Officer |

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## Exhibit 99.1

**Exhibit 99.1**

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img001.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;September 2025 Zervimesine: a Once-daily Oral Therapeutic Advancing Towards Phase 3 |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img002.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2 FORWARD-LOOKING STATEMENTS This presentation contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. All statements contained in this presentation, other than statements of historical facts or statements that relate to present facts or current conditions, including but not limited to, product candidates, including zervimesine, also known as zervimesine, and any expected or implied benefits or results, including that initial clinical results observed with respect to zervimesinewill be replicated in later trials, and our clinical development plans, including statements regarding our clinical studies of zervimesine and our regulatory plans, expectations regarding potential patient populations, expectations regarding our patent portfolio, and our expected cash runway, are forward-looking statements. These statements, including statements related to the timing and expected results of our clinical trials, involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance, or achievements to be materially different from any future results, performance, or achievements expressed or implied by the forward-looking statements. In some cases, you can identify forward-looking statements by terms such as "may," "might," "will," "should," "expect," "plan," "aim," "seek," "anticipate," "could," "intend," "target," "project," "contemplate," "believe," "estimate," "predict," "forecast," "potential" or "continue" or the negative of these terms or other similar expressions. We have based these forward-looking statements largely on our current expectations and projections about future events and financial trends that we believe may affect our business, financial condition, and results of operations. These forward-looking statements speak only as of the date of this presentation and are subject to a number of risks, uncertainties and assumptions, some of which cannot be predicted or quantified and some of which are beyond our control. Factors that may cause actual results to differ materially from current expectations include, but are not limited to: our ability to successfully advance our current and future product candidates through development activities, preclinical studies and clinical trials and costs related thereto; uncertainties inherent in the results of preliminary data, preclinical studies and earlier-stage clinical trials being predictive of the results of early or later-stage clinical trials; the timing, scope and likelihood of regulatory filings and approvals, including regulatory approval of our product candidates; competition, our ability to secure new (and retain existing) grant funding, our ability to grow and manage growth, maintain relationships with suppliers and retain our management and key employees; changes in applicable laws or regulations; the possibility that the we may be adversely affected by other economic, business or competitive factors, including ongoing economic uncertainty; our estimates of expenses and profitability; the evolution of the markets in which we compete; our ability to implement our strategic initiatives and continue to innovate our existing products; our ability to defend our intellectual property; impacts of global political changes and global economic conditions on our business, supply chain and labor force; our ability to maintain the listing of our common stock on the Nasdaq Global Market; and the risks and uncertainties described more fully in the "Risk Factors" section of our annual and quarterly reports filed with the Securities & Exchange Commission that are available on www.sec.gov. These risks are not exhaustive, and we face both known and unknown risks. You should not rely on these forward-looking statements as predictions of future events. The events and circumstances reflected in our forward-looking statements may not be achieved or occur, and actual results could differ materially from those projected in the forward-looking statements. Moreover, we operate in a dynamic industry and economy. New risk factors and uncertainties may emerge from time to time, and it is not possible for management to predict all risk factors and uncertainties that we may face. Except as required by applicable law, we do not plan to publicly update or revise any forward-looking statements contained herein, whether as a resultof any new information, future events, changed circumstances or otherwise. TRADEMARKS This presentation may contain trademarks, service marks, trade names and copyrights of other companies, which are the property of their respective owners. Solely for convenience, some of the trademarks, service marks, trade names and copyrights referred to in this presentation may be listed without the TM, SM© or® symbols, but we will assert, to the fullest extent under applicable law, the rights of the applicable owners, if any, to these trademarks, service marks, trade names and copyrights. MARKET & INDUSTRY DATA Projections, estimates, industry data and information contained in this presentation, including the size of and growth in key end markets, are based on information from third-party sources and management estimates. Although we believe that these third party-sources are reliable, we cannot guarantee the accuracy or completeness of these sources. Our management's estimates are derived from third-party sources, publicly available information, our knowledge of our industry and assumptions based on such information and knowledge. Our management's estimates have not been verified by any independent source. All of the projections, estimates, market data and industry information used in this presentation involve a number of assumptions and limitations, and you are cautioned not to give undue weight to such information. In addition, projections, estimates and assumptions relating to us and our industry's future performance are necessarily subject to a high degree of uncertainty and risk due to a variety of factors, including, but not limited to, those described above, that could cause future performance to differ materially from our expressed projections, estimates and assumptions or those provided by third parties. Forward-looking Statements |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img003.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3 Executive Summary Compelling data with first-in-class candidate supports registrational plan • Consistent efficacy signals in Alzheimer's, DLB and dry AMD - One of few compounds effective in both mild & moderate Alzheimer's disease - GA lesion growth reduced with zervimesine treatment • Well tolerated safety profile (over 450 people treated to date) - ARIA unexpected based on MoA - Modest side effect profile for use in aging population • Oral QD administration - Reduced burden compared to IV Alzheimer's therapy with required imaging surveillance; intravitreal injections for dry AMD • Potential first-to-market for dementia with Lewy bodies (DLB) - Strong responses across behavioral, functional, cognitive, and movement measures in Phase 2 SHIMMER study • Robust intellectual property covering platform & compounds, including zervimesine (CT1812) through 2040 with PTE ARIA: amyloid-related imaging abnormalities; MOA: mechanism of action; PTE: patent term extension  |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img004.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4 • BBB-penetrant small molecule oligomer antagonist • Distinct MoA: ligand of TMEM97 (sigma-2) receptor • Oral, once-daily dosing, favorable safety data • Fast Track granted for Alzheimer's disease • Phase 2 PoC in three indications Zervimesine (CT1812) – Lead Product Candidate Extensive comp of matter IP on zervimesine and other candidates developed from foundational platform lilrb2 PrPc No-Go TMEM97 PGRMC1 σ-2 Receptor Complex Oligomer receptor complex Zervimesine BBB: blood brain barrier; PoC: proof of concept |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img005.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5 Findings from Completed Studies Support Phase 3 Plans Program Preclin Phase 1 Phase 2 Phase 3 Alzheimer's disease Early-to-mild Alzheimer's disease Completed Studies Mild-to-moderate Alzheimer's disease Mild-to-moderate DLB Dry age-related macular degeneration GA secondary to dry AMD Phase 2 COG0203 • START Phase 2 COG2201 • MAGNIFY Phase 2 COG1201 • SHIMMER Phase 2 COG0201 • SHINE Takeaways from completed studies • Phase 2 SHINE Study: Efficacy across cognitive measures in mild-to-moderate Alzheimer's disease • Phase 2 SHIMMER Study: behavioral, functional, cognitive, movement benefit in mild-to-moderate DLB • Phase 2 MAGNIFY Study: slower lesion growth in geographic atrophy secondary to dry AMD  |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img006.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;95% slowing of cognitive decline in lower-p-tau217 'SHINE' participants Alzheimer's Disease |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img007.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7 Enrolled Population: • PET- or biomarker-confirmed AD • Majority of participants were female (60%), Caucasian (96%), ~ 72 yo • Mean MMSE score upon entry: 21.37 • ~60% of patients carry the ApoE4 gene • Characteristics well-balanced between all 3 arms SHINE: Phase 2 PoC in Mild-to-Moderate Alzheimer's Disease Well-executed, over-enrolled study, supports advancing clinical development Inclusion and Exclusion • AD diagnosis • PET or CSF biomarker definition of AD • MMSE 18-26 • MRI w/o significant abnormality • No MDD, schizophrenia, bipolar disorder • Stable regimen of AChEI or memantine permitted Placebo Zervimesine 100 mg Zervimesine 300 mg Oral QD Administration 1:1:1 Treatment Period 6 months 153 participants randomized in Australia, Netherlands, Spain, Czechia, and U.S. SHINE COG0201 study (NCT03507790) partially funded by $31M NIA grant R01AG058660  |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img008.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8 ADAS-Cog 11 ADAS-Cog 13 MMSE ADCS-ADL ADCS-CGIC median p-tau217 95% 103% 108% 68% 61% mITT 38% 39% 70% 26% 28% Up to 108% Percent Slowing on Assessments Strong, consistent efficacy signals across measures Cognition Function Zervimesine Pooled (100/300mg) |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img009.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;9 • Plasma p-tau217 reflects brain amyloid and tau burden • Prior data indicate that individuals with lower AD pathology at baseline, as reflected by lower levels of plasma p-tau217, have greater response to amyloid-based therapies, eg: - Donanemab TRAILBLAZER 2\* • iADRS: 36% slowing in low tau tercile • iADRS: 21% slowing in high tau tercile • Given zervimesine's MoA of displacing Aβ oligomers, we hypothesized that larger treatment effect may be observed in participants with lower plasma p-tau217 • Prespecified subgroup analysis defined by median baseline plasma p-tau217 within study population Tau Burden in Amyloid-related AD Clinical Trials Baseline plasma p-tau217: a predictive biomarker of response to therapy \* Mintun MA et al. slides presented at CTAD 2023 iARDS, Integrated Alzheimer's Disease Rating Scale  |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img010.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10 Participants with Below Median p-tau217 Experienced Profound Treatment Effect Preservation of ADAS-Cog 11 in participants below median plasma p-tau217† † Median plasma p-tau217 level is 1.0pg/mL at baseline ADAS-Cog 11\* mITT population (n=150) Below median p-tau217 (n=69) ooled er imesine lacebo S Mean SE Change from aseline 0 eek eek 1 eek 2 sl i 0 0 0 1 3 0 0 0 P val e ooled v o O served treatment di erence ooled v o 2 t L Mean hange rom Baseline ooled er imesine lacebo 0 eek eek 1 eek 2 sl i orsening 0 3 3 0 0 0 310 P val e ooled v o O served treatment di erence ooled v o 1 03 t |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img011.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;11 Consistent Treatment Impact in Participants with Lower p-tau217 Across Baseline MMSE scores Cognitive preservation (ADAS-Cog 11) observed across MMSE range Zervimesine-Treated Mild (MMSE 22-26) Zervimesine-Treated Moderate (MMSE 18-21) Participants ooled er imesine n lacebo n S Mean SE Change from aseline sl i orsening 0 eek eek 1 eek 2 0 0 0 100 0 0 P val e ooled v o O served treatment di erence ooled v o 2 t ooled er imesine n lacebo n S Mean SE Change from aseline sl i 0 eek eek 1 eek 2 0 0 2 0 0 23 P val e ooled v o O served treatment di erence ooled v o 3 2 t |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img012.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;12 Participants Evenly Distributed by Median p-tau217 and MMSE Severity Baseline Plasma p-tau217 MMSE at Screening Below Median Above Median Total Mild (22-26) 35 32 67 Moderate (18-21) 34 37 71 Total 69 69 138 MMSE at Screening vs p-tau217 at Baseline in SHINE Median MMSE Median plasma p-tau217 Mild MMSE Moderate MMSE 26 24 22 20 18 MMSE at Screening ⚫ Zervimesine 100mg ⚫ Zervimesine 300mg ⚫ Placebo Plasma pTau-217 at Baseline 3 - 2 - 1 - 0 - |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img013.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13 • Zervimesine demonstrated a favorable safety and tolerability profile • Most TEAEs were mild or moderate in severity • Similar percentages of adverse events in treated (76.5%) and placebo (78%) groups • No discontinuations due to AEs in the 100mg dose group • Most discontinuations were in 300mg group and all the reportable liver enzyme elevations were in 300mg group Summary of SHINE Safety and Tolerability findings Favorable safety profile vs placebo, AEs well balanced between arms, no ARIA \* occurring in a zervimesine treatment group at a rate >10% and at a rate >2X the placebo rate † not considered treatment related Adverse Events Zervimesine 76.5% Placebo 78.0% Zervimesine 4.9% Placebo 10.0% Serious AEs Zervimesine 0 Placebo 1 (cancer) Deaths† |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img014.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;14 • Zervimesine has favorable safety and tolerability profile - Similar percentages of AEs in pooled treated and placebo groups • All cognitive and functional measures trended in favor of zervimesine • Large cognitive impact observed in below-median plasma p-tau217 subgroup • Will assess optimal plasma p-tau217 cut-point for future studies Zervimesine SHINE Study: Summary and Conclusions Plasma p-tau217 biomarker identifies strong zervimesine-treatment responder group |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img015.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;15 • End-of-Phase 2 meeting conducted July 9, 2025 • FDA minutes received August 12, 2025 - Aligned on following design: • Adults with mild-to-moderate Alzheimer's disease • P-ta 21 at screening ≤ 1 0 g/m • 1:1 zervimesine (100mg) vs placebo for 6 months • Trial endpoints • Open-label extension to follow FDA Confirms Phase 3 Plan in Alzheimer's Disease Alignment reached with FDA during end-of-Phase 2 meeting |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img016.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;16 START – Phase 2 Early AD Study Reaches 75% Enrollment First study to allow lecanemab as background therapy in combination with zervimesine START COG0203 study (NCT05531656) partially funded by $81M NIA grant R01AG065248 Enrollment Criteria Treatment Period 18 months Assessments Program Objectives - Ages 50-85 - Diagnosis of MCI due to AD or mild AD dementia - Brain amyloid via PET - MRI - MMSE: 20-30 - Safety - Cognitive and functional testing: - CDR-SB - ADAS-Cog 13, - ADCS-ADL-MCI - Biomarkers - Fluid - imaging ✓ Identify efficacy signal(s) ✓ Confirm safety and tolerability after longer exposure ✓ Identify dose(s) for Phase 3 Placebo Zervimesine 100 mg Zervimesine 200 mg Oral QD Administration Randomized 1:1:1 Recruiting 540 adults with early AD at 30+ sites, including ACTC centers of excellence MCI, mild cognitive impairment; CDR-SB, Clinical Dementia Rating Scale Sum of Boxes; ADAS-Cog, Alzheimer's Disease Assessment Scale– Cognitive; ADL, activities of daily living; QD, daily; NIA, National Institute on Aging; ACTC, Alzheimer's Clinical Trials Consortium |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img017.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Strong clinical signals in the two primary causes of dementia: Dementia with Lewy Bodies (DLB) Mild-to-Moderate Alzheimer's Disease Dementia Programs:  |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img018.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;18 α-synuclein Amyloid beta (Aβ) • Aβ closely associated with Alzheimer's athogenesis • α-synuclein: closely associated with Lewy body dementias • Co-pathology is common - Up to 80% of DLB patients have BOTH α-synuclein and Amyloid beta (Aβ 1 - Appx 50% of Alzheimer's atients have OTH Aβ and α-synuclein2 • Zervimesine has shown protective function against α-synuclein and Aβ AD and DLB: 2 Diseases with Overlapping Pathology Primary treatment goal – slow the progression of cognitive decline Aβ + α-synuclein 1. NIH Requests for Application RFA-NS-25-010 accessed 12/09/2024 https://tinyurl.com/26d6ertd 2. Bassil F et al. Neuron. 2019 Nov 20;105(2):260–275.e6. https://doi.org/10.1016/j.neuron.2019.10.010 |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img019.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Strong clinical signals across four major symptom domains in Phase 2 SHIMMER Study Dementia with Lewy Bodies (DLB) |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img020.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;20 Dementia with Lewy Bodies (DLB) Core Symptoms of DLB Fluctuating cognition and alertness Neuropsychiatric symptoms such as visual hallucinations, anxiety, depression and delusions Decline in cognition, attention, executive function Spontaneous parkinsonism REM sleep behavior disorder More common in men 2nd most common cause of dementia after Alzheimer's disease Patients may have faster decline than Alzheimer's Characterized by cognitive impairment that precedes development of motor symptoms Patients often require several physician visits over 18 months before being correctly diagnosed |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img021.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;21 SHIMMER Study in Dementia with Lewy Bodies Conducted in collaboration with experts at LBDA and University of Miami SHIMMER COG1201 study (NCT05225415) partially funded by $30M NIA grant R01AG071643 Enrollment Criteria Treatment Period 6 months Assessments Program Objectives - Age 50-85 - DLB diagnosis - MRI - MMSE: 18-27 - Safety/tolerability - Global CGIC - Cognition - MoCA, MMSE, CDR - Function - UPDRS III, CAF, ADL - Behavior - NPI, Epworth Sleep - Biomarkers ✓ Identify efficacy signal(s) ✓ Confirm safety and tolerability profile ✓ Identify dose(s) for Phase 3 ✓ Explore impact on behavioral symptoms of sleep and fluctuations Placebo Zervimesine 100 mg Zervimesine 300 mg Oral QD Administration Randomized 1:1:1 130 participants randomized from 31 sites across U.S. , including LBDA centers of excellence DLB, Dementia with Lewy Bodies; MMSE, Mini-Mental State Examination; MRI, magnetic resonance imaging; QD, daily; NIA, National Institute on Aging; LBDA, Lewy Body Dementia Association |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img022.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;22 Behavior Cognition Function Movement Four Symptom Domains Drive Lewy Body Disease Burden "A m ltifactorial disease with a ffet of sym toms" Patient symptom Hallucinations, anxiety, delusions Memory and problem solving Bathing, toileting, shopping, meal preparation Standing, maintaining balance Assessment tool Neuropsychiatric Inventory (NPI) Cognitive Drug Research (CDR) System ADCS-Activities of Daily Living (ADL) MDS-Unified Parkinson's Disease Rating Scale (UPDRS) Care Partner's NPI of "Distress" Montreal Cognitive Assessment (MoCA) Clinician Assessment of Fluctuation (CAF) |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img023.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;23 Up to 91% Percent Slowing on Assessments Strong clinical signals across major DLB symptoms relative to placebo \* Measure of the distress experienced by the care partners of SHIMMER participants Zervimesine Pooled (100/300mg) NPI (total) NPI (distress) CDR (episodic memory) MoCA CAF ADCS-ADL UPDRS 86% 114% 85% 60% 91% 52% 62% Behavior Cognition Function Movement |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img024.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;24 Zervimesine Showed Dramatic 86% Impact on Neuropsychiatric Measures NPI captures a variety of patient disturbances, including hallucinations, anxiety, and delusions NPI: Neuropsychiatric inventory NPI favor Treatment with Zervimesine LS Mean Difference from Placebo 95% CI Favors zervimesine P-value (pooled v pbo) 0.745 0.277 0.054 NPI NPI Total Score (A-L) 86% Slowing -3 -2 -1 0 1 2 Apathy Elation/Euphoria Aberrant Motor Disinhibitions Irritability Appetite Sleep Behaviour Depression Agitation/Aggresssion Hallucinations Delusions Anxiety |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img025.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;25 -1.5 -1 -0.5 0 0.5 1 1.5 Apathy Elation/Euphoria Aberrant Motor Disinhibitions Irritability Appetite Sleep Behaviour Depression Agitation/Aggresssion Hallucinations Delusions Anxiety Favors zervimesine Because Participants Improved in Hallucinations, Delusions & Anxiety, Caregivers were Notably Better New tool created to measure caregiver burden in DLB NPI Distress: Neuropsychiatric inventory (Care Partner Distress) NPI Distress favors Treatment with Zervimesine LS Mean Difference from Placebo 95% CI NPI Distress NPI Total Score (A-L) Caregiver Distress 114% Slowing P-value (pooled v pbo) 0.598 0.288 0. 025 |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img026.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;26 0 Week 4 Week 14 Week 26 0.979 0.643 0.550 Up to 91% Slowing of Cognitive Decline Across Assessments Zervimesine im roved atients' attentiveness and ro lem solving CDR: Cognitive Drug Research (CDR) Battery; MoCA: Montreal Cognitive Assessment; CAF: Clinician Assessment of Fluctuation CDR - Episodic Memory (ITT) MoCA (ITT) CAF (Fluctuations) (ITT) 0 Week 4 Week 14 Week 26 P-value (pooled v pbo) 0.674 0.539 0.152 0 Week 4 Week 14 Week 26 0.137 0.429 0.2097 Worsening LS Mean (SE) Change from Baseline -30.0 -25.0 -20.0 -15.0 -10.0 -5.0 0.0 5.0 10.0 -3.0 -2.0 -1.0 0.0 1.0 2.0 -2.0 -1.5 -1.0 -0.5 0.0 0.5 1.0 1.5 2.0 CT1812 300mg (n=44) Placebo (n=42) CT1812 100mg (n=44) 85% slowing 60% slowing 91% slowing |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img027.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;27 People on Zervimesine Maintained Self-care 52% preservation in activities of daily living (ADL) measures ADCS-ADL: Activities of Daily Living -12.0 -10.0 -8.0 -6.0 -4.0 -2.0 0.0 2.0 CT1812 100 mg (n=44) CT1812 300 mg (n=44) Placebo (n=42) Worsening Components of ADL Score Bathing Toileting Dressing Conversing Grooming Shopping Feeding Writing 0 Week 4 Week 14 Week 26 P-value (pooled v pbo) 0.165 0.151 0. 0503 LS Mean (SE) Change from Baseline ADCS-ADL 52% slowing |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img028.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;28 -4.0 -2.0 0.0 2.0 4.0 6.0 8.0 CT1812 100 mg (n=44) CT1812 300 mg (n=44) Placebo (n=42) People Treated with Zervimesine Maintained Motor Function 62% preservation in measures of movement ADCS-ADL: Activities of Daily Living Worsening Components of UPDRS: Balance Speech Rigidity Tremor Gait Facial expression LS Mean (SE) Change from Baseline 0 Week 4 Week 14 Week 26 P-value (pooled v pbo) 0.394 0.381 0.191 MDS-UPDRS3 62% slowing |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img029.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;29 SHIMMER Met and Exceeded Objectives and Expectations Identified consistent signals of efficacy with a favorable tolerability profile\* COG1201 SHIMMER was a phase 2a safety and tolerability study seeking signals of efficacy in people with dementia with Lewy bodies The safety and tolerability profile was similar to past experience with zervimesine (CT1812) Clear signals of efficacy were observed • Across Behavioral, Cognitive, Functional and Motor domains • Treatment differences increased over 6 months These data provide support for advancement of zervimesine as a treatment for dementia with Lewy bodies \* Although breakthrough designation was not granted for zervimesine by FDA for DLB, Cognition will explore other expedited development pathways  |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img030.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;30 Summary of SHIMMER Safety and Tolerability findings \* occurring in a CT1812 treatment group at a rate >10% and at a rate >2X the placebo rate † not considered treatment related Favorable safety profile vs placebo, AEs well balanced between arms Adverse Events Serious AEs Deaths† CT1812 94.3% 10.3% 2 (2.2)% Placebo 88.1% 19.0% 1 (2.4)% Total AE frequency was similar in CT1812 and placebo There were no deaths related to study drug Participants with LFT elevations ≥ 3x U N • 100mg CT1812 – 3 • 300mg CT1812 – 6 Most AEs were mild or moderate Study Discontinuations due to AEs not • Placebo – 0 related to LFTs: • Placebo – 4.8% • 100mg CT1812 – 4.5% • 300 mg CT1812 – 9.3% Fewer Serious AE occurred in the CT1812 treated group compared to placebo treated Most common AEs\* (other than increased LFTs) in the CT1812 group were diarrhea and abdominal discomfort |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img031.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;GA lesion growth slower with zervimesine treatment MAGNIFY Topline Results |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img032.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;32 MAGNIFY Trial in Dry AMD/GA Zervimesine: oral drug development candidate for geographic atrophy Enrollment Criteria Treatment Period 24 months Assessments Program Objectives - Age ≥ 50 - Diagnosis of dry AMD - CVA ≥ 2 letters (ETDRS) - GA lesion ≥ 2 5 and ≤1 5mm2 - Change in GA lesion area (FAF) - Ellipsoid zone area (SD-OCT) - Drusen volume (SD-OCT) - BCVA; LL-BCVA - Safety - Identify efficacy signal(s) - Assess potential to treat two eyes simultaneously - Confirm safety and tolerability profile at 200mg dose Placebo Zervimesine 200 mg Oral QD Administration Randomized 1:1 Adults with GA secondary to dry AMD recruited at ~20 US sites BVCA, best corrected visual acuity; FAF, fundus autofluorescence; SD-OCT, spectral domain optical coherence tomography |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img033.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;33 • 29% mean rate of change (slope) in GA lesion area vs placebo (p=0.0538) • Change in GA progression rate favored zervimesine vs placebo at each timepoint - 6-months: -11.79% - 12-months: -15.83% - 18-months: -28.19% (p=0.0074) • Effect size increases with longer study duration Effect size increases with exposure Zervimesine Treatment Slowed GA Lesion Growth |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img034.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;34 Zervimesine Slowed GA Lesion Growth Rate (slope) and Area (observed) 1) Data on file: Cognition Therapeutics FAF: Fundus Autofluorescence Slope Analysis1 Mean Area by Time1 Zervimesine Placebo Diff Growth rate (mm2 / month) 0.10 ± 0.015 0.14 ± 0.014 - 0.04 Annualized Growth rate (mm2 / year) 1.23 1.73 - 0.50 Percent Difference from Placebo 29% (P=0.054) S Mean Change from aseline in GA lesion size mm2 y FAF Months zervimesine lace o P 0 00 11 15 3 2 1 Di erence treated vs lace o 1 1 3 1 3 3 3 Zervimesine n's Place o n's |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img035.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;35 0 5 10 15 20 25 30 35 1 2 1 Percent Di erence from Place o Months Zervimesine Effect Size Comparable to SoC IVT with Oral Once-Daily Dosing 1) Izervay package insert, Page 15 Table 2: https://tinyurl.com/294dwnxe 2) Goldberg et al. 18-month results presented at ARVO 2022: https://tinyurl.com/28g9er4h 3) Data on file: Cognition Therapeutics Topline MAGNIFY Results3 Compared to Published Results1,2: Percent Reduction in GA Lesion Growth Over Time IZERVAY Avacincaptad pegol (2mg)1 • Gather1 at 18 months – 35% • Gather2 at 12 months – 18% • Gather2 at 24 months – 14% SYFOVRE Pegcetacoplan (15mg)2 • Derby at 18 months – 13% • Oaks at 18 months – 22% Above data are derived from clinical trials conducted with different designs and patient populations. No head-to-head studies have been conducted.  |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img036.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;36 COG2201 (MAGNIFY): Safety Summary Favorable safety and tolerability profile ULN: upper limit of normal; AST: aspartate aminotransferase; ALT: alanine transaminase al la e er imesi e e s i h At least one TEAE n 3 3 0 0 At least one TEAE ossi ly/ ro a ly related to treatment 12 2 5 1 1 0 At least one TEAE leading to treatment discontin ation 2 3 5 0 At least one lar TEAE leading to treatment discontin ation 1 2 0 0 1 1 0 At least one serio s AE leading to treatment discontin ation 0 1 2 0 1 1 0 Serio s TEAEs 12 2 11 12 12 0 Serio s lar TEAEs 0 0 0 AE of s ecial Interest FTs ≥ 3x U N AST or A T 2 0 0 AE severity s ects with Mild 1 3 15 2 33 33 0 Moderate 1 3 1 33 3 3 3 0 Severe 3 1 0  |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img037.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;37 3 Major Diseases Addressed with Once-Daily Oral Pill Collective Phase 2 Results Supports Advancing Zervimesine (CT1812) to Registrational Studies Dementia with Lewy Bodies Marked slowing of progression across multiple domains Geographic Atrophy Slowing of GA growth rate and area Alzheimer's Disease Slowing of progression; robust response in lower tau cohort |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img038.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;38 Executive Summary First-in-class oligomer antagonist with compelling efficacy data • Consistent efficacy signals in Alzheimer's, DLB and dry AMD - One of few compounds effective in both mild & moderate Alzheimer's disease - GA lesion growth reduced with zervimesine treatment • Well tolerated safety profile (over 450 people treated to date) - ARIA unexpected based on MoA - Modest side effect profile for use in aging population • Oral QD administration - Reduced burden compared to IV Alzheimer's therapy with required imaging surveillance; intravitreal injections for dry AMD • Potential first-to-market for dementia with Lewy bodies (DLB) - Strong responses across behavioral, functional, cognitive, and movement measures in Phase 2 SHIMMER study • Robust intellectual property covering platform & compounds, including zervimesine (CT1812) through 2040 with PTE ARIA: amyloid-related imaging abnormalities; MOA: mechanism of action; PTE: patent term extension  |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img039.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;39 $30 Million Equity Raise Closed August 2025 Current Financial Position Cash and cash equivalents $11.6 M Grant funding for zervimesine studies Preclinical through Phase 2 ~$171 M Approximate funding used ($129 M) Remaining grant funding $42 M As of quarter ended June 30, 2025 |

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| &nbsp;&nbsp;![GRAPHIC](tm2525997d1_ex99-1img040.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Thank You Lisa Ricciardi President & CEO info@cogrx.com |

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