# EDGAR Filing Document

**Accession Number:** 0001131343
**File Stem:** 0001213900-25-098901
**Filing Date:** 2025-10
**Character Count:** 10242
**Document Hash:** 836a6fafb73b01adb551732ea1bcdf1c
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001213900-25-098901.hdr.sgml**: 20251015

**ACCESSION NUMBER**: 0001213900-25-098901

**CONFORMED SUBMISSION TYPE**: 6-K

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20251014

**FILED AS OF DATE**: 20251015

**DATE AS OF CHANGE**: 20251014

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** ALTERITY THERAPEUTICS LTD
- **CENTRAL INDEX KEY:** 0001131343
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** C3
- **FISCAL YEAR END:** 0630

**FILING VALUES:**
- **FORM TYPE:** 6-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 000-49843
- **FILM NUMBER:** 251392971

**BUSINESS ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** LEVEL 3, 460 BOURKE STREET
- **CITY:** MELBOURNE
- **PROVINCE COUNTRY:** C3
- **BUSINESS PHONE:** 61 3 9349 4906

**MAIL ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** LEVEL 3, 460 BOURKE STREET
- **CITY:** MELBOURNE
- **PROVINCE COUNTRY:** C3

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** PRANA BIOTECHNOLOGY LTD
- **DATE OF NAME CHANGE:** 20010105

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**FORM 6-K**

**REPORT OF FOREIGN PRIVATE ISSUER**

**PURSUANT TO RULE 13a-16 OR 15d-163**

**UNDER THE SECURITIES EXCHANGE ACT OF 1934**

**For the month of October 14, 2025**

**Alterity Therapeutics Limited**

(Name of Registrant)

**Level 14, 350 Collins Street, Melbourne, Victoria 3000 Australia**

(Address of Principal Executive Office)

**Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.**

Form 20-F ☒ Form 40-F ☐

**This Form 6-K is being incorporated by reference into our Registration Statement on Form S-8 (Files No. [333-251073](http://www.sec.gov/Archives/edgar/data/1131343/000121390020040485/ea130838-s8_alteritytherape.htm), [333-248980](http://www.sec.gov/Archives/edgar/data/1131343/000121390020027969/ea127207-s8_alteritytherap.htm) and [333-228671](http://www.sec.gov/Archives/edgar/data/1131343/000114420418063081/tv508429_s-8.htm)) and our Registration Statements on Form F-3 (Files No. [333-274816](http://www.sec.gov/Archives/edgar/data/1131343/000101376223000033/ea185947-f3_alteritytherape.htm), [333-251647](http://www.sec.gov/Archives/edgar/data/1131343/000121390020044324/ea132148-f3_alteritytherape.htm), [333-231417](http://www.sec.gov/Archives/edgar/data/1131343/000114420419025615/tv521271_f3.htm) and [333-250076](http://www.sec.gov/Archives/edgar/data/1131343/000121390020036934/ea129831-f3_alteritytherap.htm))**

**ALTERITY THERAPEUTICS LIMITED**

**(a development stage enterprise)**

The following exhibits are submitted:

99.1 [Change in substantial holding](ea026113401ex99-1_alterity.htm)

**<u>SIGNATURE</u>**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

---

| | |
|:---|:---|
| **Alterity Therapeutics Limited** | **Alterity Therapeutics Limited** |
| By: | /s/ Geoffrey P. Kempler |
|  | Geoffrey P. Kempler |
|  | Chairman |

---

Date: October 14, 2025

## Exhibit 99.1

**Exhibit 99.1**

**Form 604**

**Corporations Act 2001**

**Section 671B**

**Notice of change of interests of substantial holder**

To Company Name/Scheme <u>Alterity Therapeutics ltd (ATH) </u> <br> ACN/ARSN <u>080 699 065</u>

1. Details of substantial holder (1)

Name <u>Regal Funds Management Pty Limited and its associates (see Annexure 1)</u> <br> ACN/ARSN (if applicable) <u>-</u>

---

| | |
|:---|:---|
| There was a change in the interests of the substantial holder on | **10/10/2025** |
| The previous notice was given to the company on | **8/04/2025** |
| The previous notice was dated | **4/04/2025** |

---

2. Previous and present voting power

The total number of votes attached to all the voting shares in the company or voting interests in the scheme that the substantial holder or an associate (2) had a relevant interest (3) in when last required, and when now required, to give a substantial holding notice to the company or scheme, are as follows:

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | Previous notice | Previous notice | Current notice | Current notice |
| Class of securities (4) | Person's votes | Voting power (5) | Person's votes | Voting power (5) |
| ORDINARY | 1255948179 | 13.76% | 1623521925 | 14.93%\* |

---

\* The % substantial is based on the shares on issue of 10,875,416,329 as disclosed by the Company on 15-09-2025.

3. Changes in relevant interests

Particulars of each change in, or change in the nature of, a relevant interest of the substantial holder or an associate in voting securities of the company or scheme, since the substantial holder was last required to give a substantial holding notice to the company or scheme are as follows:

Holder of relevant interest <u>Date of acquisition</u> <u>Consideration (9)</u> <u>Class and number of securities</u> <br>   <u>See Annexure 2</u>    

4. Present relevant interests

Particulars of each relevant interest of the substantial holder in voting securities after the change are as follows:

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| Holder of relevant interest | Registered holder of securities | Person entitled to be registered as holder (8) | Nature of relevant interest (6) | Class and number of securities | Person's votes |
| Regal Funds Management <br> Pty Ltd and its associates | UBS NOMINEES PTY LTD | UBS AG, AUSTRALIA BRANCH | Power to control the<br> exercise of a power<br> to dispose of securities | 1,017,244,356<br> ORDINARY | 1017244356 |
| Regal Funds Management <br> Pty Ltd and its associates | HSBC CUSTODY NOMINEES<br> (AUSTRALIA) LIMITED <br> A/C 2 | MORGAN STANLEY & CO INTL <br> PLC | Power to control the exercise of a power to dispose of securities | 138,522,571 ORDINARY | 138522571 |
| Regal Funds Management<br> Pty Ltd and its associates | MERRILL LYNCH (AUS) NOMINEES PTY LTD | MERRILL LYNCH INTERNATIONAL LIMITED | Power to control the exercise of a power to dispose of securities | 54,229,997 ORDINARY | 54229997 |
| Regal Funds Management <br> Pty Ltd and its associates | J.P. MORGAN PRIME NOMINEES LTD | J.P MORGAN SECURITIES PLC | Power to control the<br> exercise of a power<br> to dispose of<br> securities | 65,853,821<br> ORDINARY | 65853821 |
| Regal Funds Management<br> Pty Ltd and its associates | CITICORP NOMINEES PTY LIMITED | CITIGROUP GLOBAL MARKETS<br> LIMITED | Power to control the <br> exercise of a power <br> to dispose of securities | 179,152,998<br> ORDINARY | 179152998 |
| Regal Funds Management <br> Pty Ltd and its associates | J.P. MORGAN NOMINEES AUSTRALIA<br> LTD | J.P MORGAN NOMINEES AUSTRALIA LTD | Power to control the <br> exercise of a power <br> to dispose of securities | 168,518,182<br> ORDINARY | 168518182 |

---

5. Changes in association

The persons who have become associates (2) of, ceased to be associates of, or have changed the nature of their association (9) with, the substantial holder in relation to voting interests in the company or scheme are as follows:

Name and ACN/ARSN (if applicable) <u>Nature of association</u> <br> <u>N/A</u>

6. Addresses

The addresses of persons named in this form are as follows:

Name <u>Address</u> <br> <u>REGAL FUNDS MANAGEMENT PTY LIMITED</u> <u>LEVEL 46, GATEWAY, 1 MACQUARIE PLACE, SYDNEY<br> NSW 2000</u> <br> <u>REGAL PARTNERS LIMITED</u> <u>LEVEL 46, GATEWAY, 1 MACQUARIE PLACE, SYDNEY<br> NSW 2000</u>

**Signature**

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| | | | |
|:---|:---|:---|:---|
| print name | Ian Cameron | capacity | Director |
| **sign here** | /s/ Ian Cameron | **date** | 14/10/2025 |

---

**Annexure 1**

**Details of Substantial Holders**

---

| | |
|:---|:---|
| **ACN** | **Name** |
| 107 576 821 | REGAL FUNDS MANAGEMENT PTY LIMITED |
| 129 188 450 | REGAL PARTNERS LIMITED |

---

**Annexure 2**

**Changes in Relevant Interests**

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| **Date** | **Person whose relevant interest changed** | **Nature of<br> Change** | **Consideration<br> given in relation<br> to change** | **Number of<br> securities<br> affected** | **Class of<br> securities** | **Persons<br> votes<br> affected** |
| 7/04/2025 | Regal Funds Management Pty Limited (and Regal<br> Partners Limited by virtue of control of Regal Funds Management Pty Limited) | Sell | 1330000.00 | 190000000 | &nbsp;&nbsp;&nbsp;&nbsp;Ordinary | &nbsp;&nbsp;&nbsp;&nbsp;190000000 |
| 7/04/2025 | Regal Funds Management Pty Limited (and Regal <br> Partners Limited by virtue of control of Regal Funds Management Pty Limited) | Buy | 1330000.00 | 190000000 | &nbsp;&nbsp;&nbsp;&nbsp;Ordinary | &nbsp;&nbsp;&nbsp;&nbsp;190000000 |
| &nbsp;&nbsp;&nbsp;&nbsp;21/07/2025 | Regal Funds Management Pty Limited (and Regal <br> Partners Limited by virtue of control of Regal Funds Management Pty Limited) | Buy | 294000.00 | 21000000 | &nbsp;&nbsp;&nbsp;&nbsp;Ordinary | 21000000 |
| &nbsp;&nbsp;&nbsp;&nbsp;10/09/2025 | Regal Funds Management Pty Limited (and Regal <br> Partners Limited by virtue of control of Regal Funds Management Pty Limited) | Buy | 2524491.24 | 210374270 | &nbsp;&nbsp;&nbsp;&nbsp;Ordinary | &nbsp;&nbsp;&nbsp;&nbsp;210374270 |
| &nbsp;&nbsp;&nbsp;&nbsp;2/10/2025 | Regal Funds Management Pty Limited (and Regal <br> Partners Limited by virtue of control of Regal Funds Management Pty Limited) | Buy | &nbsp;&nbsp;&nbsp;&nbsp;743826.60 | 75134000 | &nbsp;&nbsp;&nbsp;&nbsp;Ordinary | &nbsp;&nbsp;&nbsp;&nbsp;75134000 |
| &nbsp;&nbsp;&nbsp;&nbsp;6/10/2025 | Regal Funds Management Pty Limited (and Regal <br> Partners Limited by virtue of control of Regal Funds Management Pty Limited) | Buy | 316679.00 | 28789000 | &nbsp;&nbsp;&nbsp;&nbsp;Ordinary | &nbsp;&nbsp;&nbsp;&nbsp;28789000 |
| &nbsp;&nbsp;&nbsp;&nbsp;10/10/2025 | Regal Funds Management Pty Limited (and Regal <br> Partners Limited by virtue of control of Regal Funds Management Pty Limited) | Buy | 355041.24 | 32276476 | &nbsp;&nbsp;&nbsp;&nbsp;Ordinary | &nbsp;&nbsp;&nbsp;&nbsp;32276476 |

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