# EDGAR Filing Document

**Accession Number:** 0001479615
**File Stem:** 0001193125-26-210428
**Filing Date:** 2026-5
**Character Count:** 16421
**Document Hash:** 8deabffc85d313f49f043950b9b9abee
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-26-210428.hdr.sgml**: 20260507

**ACCESSION NUMBER**: 0001193125-26-210428

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 10

**CONFORMED PERIOD OF REPORT**: 20260507

**ITEM INFORMATION**: Results of Operations and Financial Condition

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20260507

**DATE AS OF CHANGE**: 20260507

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Silence Therapeutics plc
- **CENTRAL INDEX KEY:** 0001479615
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** X0

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-39487
- **FILM NUMBER:** 26950998

**BUSINESS ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** 12 HAMMERSMITH GROVE
- **STREET 2:** OFFICE 205
- **CITY:** LONDON
- **PROVINCE COUNTRY:** X0
- **ZIP:** W6 7AP
- **BUSINESS PHONE:** 44-0-20-3457 6900

**MAIL ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** 12 HAMMERSMITH GROVE
- **STREET 2:** OFFICE 205
- **CITY:** LONDON
- **PROVINCE COUNTRY:** X0
- **ZIP:** W6 7AP

?xml version='1.0' encoding='ASCII'? 8-K

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**WASHINGTON, D.C. 20549** 

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**FORM** 8-K

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**CURRENT REPORT** 

**Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934** 

**Date of Report (Date of earliest event reported):** May 7, 2026

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Silence Therapeutics plc

**(Exact name of Registrant as Specified in Its Charter)** 

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| | | |
|:---|:---|:---|
| England and Wales | 001-39487 | Not Applicable |
| **(State or Other Jurisdiction**<br>**of Incorporation)** | **(Commission File Number)** | **(IRS Employer**<br>**Identification No.)** |
| 12 Hammersmith Grove <br>London<br>United Kingdom |  | W6 7AP |
| **(Address of Principal Executive Offices)** |  | **(Zip Code)** |

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**Registrant's Telephone Number, Including Area Code: +**44 20 3457 6900

**Not Applicable** 

**(Former Name or Former Address, if Changed Since Last Report)** 

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Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) 

☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) 

☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) 

☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) 

Securities registered pursuant to Section 12(b) of the Act:

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| | | |
|:---|:---|:---|
| **Title of each class** | **Trading**<br>**Symbol(s)** | **Name of each exchange on which registered** |
| American Depositary Shares, each representing three ordinary shares, nominal value £0.05 per share  | SLN | The Nasdaq Stock Market LLC<br>|
| Ordinary share, nominal value £0.05 per share\* | \* | The Nasdaq Stock Market LLC |

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\* *Not for trading, but only in connection with the listing of the American Depositary Shares on The Nasdaq Stock Market LLC.*

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

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**Item 2.02 Results of Operations and Financial Condition.** 

On May 7, 2026, Silence Therapeutics plc (the "Company") issued a press release announcing its financial results for the first quarter ended March 31, 2026, as well as recent business highlights. A copy of the press release is furnished as Exhibit 99.1 to this report and incorporated by reference.

The information in this Item 2.02 of this Current Report on 8-K, including Exhibit 99.1 hereto, is being furnished and shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liabilities of that section, and shall not be deemed incorporated by reference into any of the Company's filings under the Securities Act of 1933, as amended (the "Securities Act"), or the Exchange Act, whether made before or after the date hereof, regardless of any general incorporation language in such filing, except as shall be expressly set forth by specific references in such filing.

**Item 9.01 Financial Statements and Exhibits**

**(d) Exhibits.**

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| | |
|:---|:---|
| **Exhibit**<br>**Number** | **Description** |
| 99.1 | [<u>Press Release dated May 7, 2026</u>](sln-ex99_1.htm) |
| 104 | Cover Page Interactive Data File (embedded within the Inline XBRL document) |

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**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

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| | | |
|:---|:---|:---|
|  | **SILENCE THERAPEUTICS PLC** | **SILENCE THERAPEUTICS PLC** |
| Date: May 7, 2026 | By: | /s/ Iain Ross |
|  |  | Name: Iain Ross |
|  |  | Title: Interim Principal Executive Officer and Chairman of the Board of Directors <br>*(Principal Executive Officer)*<br>|

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## Exhibit 99.1

Exhibit 99.1

**Silence Therapeutics Highlights Recent Business Achievements and Reports First Quarter 2026 Financial Results**

*Phase 2 SANRECO trial of divesiran, a first-in-class siRNA for polycythemia vera (PV), on-track for topline results in August 2026*

7 May 2026

LONDON, Silence Therapeutics plc, Nasdaq: SLN ("Silence" or "the Company"), a global clinical-stage company developing novel siRNA (short interfering RNA) therapies, today reported its financial results for the first quarter ended March 31, 2026, and provided an update on recent business achievements.

"The Silence team continues to advance research supporting the broad potential of our mRNAi GOLD™ platform, and we remain well positioned as we approach a significant company milestone," said Iain Ross, Chairman and Interim Principal Executive Officer at Silence. "With Phase 2 topline results in PV expected this August, our team remains focused on progressing divesiran and delivering long-term value for patients and shareholders."

**<u>Business Highlights</u>**

***Divesiran: First-in-class siRNA for PV***

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•SANRECO Phase 1 study abstract accepted for poster presentation at the European Hematology Association (EHA) 2026 Annual Congress taking place June 11-14, 2026.

o**Divesiran, A Novel GalNac Conjugated SiRNA, Reduces Phlebotomies, Improves Iron Stores and Symptoms in Polycythemia Vera Patients in SANRECO Phase 1 Study**

Abstract #PF886, Poster Session 1 on Friday, June 12 (6:45-7:45 p.m. EST)

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•SANRECO Phase 2 double-blind, placebo-controlled study evaluating divesiran 6 mg (Q6W and Q12W dosing intervals) in 48 phlebotomy-dependent PV patients is ongoing with topline results on-track for August 2026.

***SLN312 (AZD1705): Phase 1 siRNA with a competitive profile for dyslipidemia***

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Phase 1 study abstract accepted for late-breaking oral presentation at the European Atherosclerosis Society (EAS) Congress taking place May 24-27, 2026.

o**Liver-Targeted ANGPTL3 Silencing with AZD1705 Lowers Atherogenic Lipoproteins: Preclinical Validation and Phase 1 Results**

Abstract #1610, Late Breaker Clinical Abstracts Session on Tuesday, May 26 (3:45–5:15pm EST)

**<u>First Quarter 2026 Financial Results</u>**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•**Cash Position:** Cash, cash equivalents, and short-term investments were $70.1 million as of March 31, 2026. This includes cash and cash equivalents of $5.7 million and short-term investments of $64.4 million.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•**Collaboration Revenue:** Collaboration revenue recognized under our agreement with AstraZeneca was $0.4 million for the three months ended March 31, 2026, compared to $0.1 million for the three months ended March 31, 2025.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•**R&D Expenses:** Research and development (R&D) expenses were $9.1 million for the three months ended March 31, 2026, compared to $20.8 million for the three months ended March 31, 2025. The decrease is largely due to the zerlasiran Phase 3 readiness being completed in 2025.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•**G&A Expenses:** General and administrative (G&A) expenses were $7.0 million for the three months ended March 31, 2026, compared to $7.7 million for the three months ended March 31, 2025.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•**Net Loss:** Net loss was $15.0 million, or $0.11 basic and diluted net loss per share for the three months ended March 31, 2026, compared to a net loss of $28.5 million, or $0.20 basic and diluted net loss per share for the three months ended March 31, 2025.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•**Total outstanding shares** were 141,703,840 ordinary shares (including shares in the form of American Depositary Shares) as of March 31, 2026.

**About Silence Therapeutics**

Silence Therapeutics is a global clinical-stage biotechnology company committed to transforming people's lives by silencing diseases through precision engineered medicines created with proprietary siRNA (short interfering RNA) technology. Silence leverages its mRNAi GOLD™ platform to create innovative siRNA therapies designed to precisely target and silence genes that cause disease. The Company is advancing a growing pipeline of siRNA product candidates targeting areas of high unmet need across rare and common diseases where treatments are limited or inadequate. For more information, please visit https://www.silence-therapeutics.com/.

**Forward-Looking Statements**

This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. In some cases, you can identify forward-looking statements by terminology such as "aim," "anticipate," "assume," "believe," "contemplate," "continue," "could," "design," "due," "estimate," "expect," "goal," "intend," "may," "objective," "plan," "positioned," "potential," "predict," "seek," "should," "target," "will," "would" and other similar expressions that are predictions of or indicate future events and future trends, or the negative of these terms or other comparable terminology. All statements other than statements of historical facts contained in this press release are forward-looking statements. These forward-looking statements include, but are not limited to, statements about: the Company's business strategy and plans, including the Company's clinical development activities and timelines; the potential therapeutic benefits of the Company's product candidates; the anticipated timing of initial topline and future results from the SANRECO Phase 2 trial; the Company's ability to deliver long-term value; and the Company's ability to advance additional candidates from its mRNAi GOLD™ platform. Forward-looking statements are not guarantees of future performance and are subject to risks and uncertainties that could cause actual results and events to differ materially from those anticipated, including, but not limited to, risks and uncertainties related to: the company's history of net operating losses; the company's ability to obtain necessary capital to fund its clinical programs; the early stages of clinical development of the company's product candidates; the company's ability to obtain regulatory approval of and successfully commercialize its product candidates either on its own or with potential partners; any undesirable side effects or other properties of the company's product candidates; the company's reliance on third-party suppliers and manufacturers; the outcomes of any future collaboration agreements; and the company's ability to adequately maintain intellectual property rights for its product candidates. These and other risks are described in greater detail under the section titled "Risk Factors" contained in the company's Annual Report on Form 10-K and Quarterly Reports on Form 10-Q and the company's other filings with the SEC. Any forward-looking statements that the Company makes in this press release are made pursuant to the Private Securities Litigation Reform Act of 1995, as amended, and speak only as of the date of this press release. Except as required by law, the company undertakes no obligation to publicly update any forward-looking statements, whether as a result of new information, future events or otherwise.

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**Inquiries:**

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| | |
|:---|:---|
| &nbsp;&nbsp;**Silence Therapeutics plc**<br>Gem Hopkins, VP, IR and Corporate Communications<br>ir@silence-therapeutics.com<br>| &nbsp;&nbsp;Tel: +1 (646) 637-3208<br>|

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**Silence Therapeutics plc**

**Condensed Consolidated Balance Sheets**

**(Unaudited, in thousands, except share and per share data)**

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| | | |
|:---|:---|:---|
|  | **March 31, 2026** | **December 31, 2025** |
| **Current assets** |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Cash and cash equivalents | $5657 | $11277 |
| &nbsp;&nbsp;&nbsp;&nbsp;Short-term investments | 64421 | 73837 |
| &nbsp;&nbsp;&nbsp;&nbsp;R&D benefit receivable | 22216 | 22007 |
| &nbsp;&nbsp;&nbsp;&nbsp;Other current assets | 10558 | 11537 |
| &nbsp;&nbsp;&nbsp;&nbsp;Trade receivables | - | - |
| **Total current assets** | **102852** | **118658** |
| Property, plant and equipment | 1396 | 1581 |
| Operating lease right-of-use assets | 142 | 167 |
| Goodwill | 10358 | 10621 |
| Other intangible assets | 248 | 288 |
| Other long-term assets | 127 | 127 |
| **Total assets** | $**115123** | $**131442** |
| **Current liabilities** |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Contract liabilities | $- | $(168) |
| &nbsp;&nbsp;&nbsp;&nbsp;Trade and other payables | (10367) | (13356) |
| &nbsp;&nbsp;&nbsp;&nbsp;Operating lease liabilities, current | (93) | (89) |
| **Total current liabilities** | **(10460)** | **(13613)** |
| Contract liabilities | (55218) | (55454) |
| Operating lease liabilities | (43) | (71) |
| **Total liabilities** | $**(65721)** | $**(69138)** |
| Commitments and contingencies (Note 11) |  |  |
| **Shareholders' equity** |  |  |
| Ordinary shares - par value £0.05 per share; 141,703,840 shares<br> issued at March 31, 2026 (December 31, 2025: 141,701,848) | (10290) | (10290) |
| Additional paid-in capital | (620006) | (617562) |
| Accumulated deficit | 577526 | 562572 |
| Accumulated other comprehensive loss | 3368 | 2976 |
| **Total shareholders' equity** | **(49402)** | **(62304)** |
| **Total liabilities and shareholders' equity** | $**(115123)** | $**(131442)** |

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**Silence Therapeutics plc**

**Condensed Consolidated Statements of Operations**

**(Unaudited, in thousands, except share and per share data)**

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| | | |
|:---|:---|:---|
|  | **Three months ended March 31,** | **Three months ended March 31,** |
|  | 2026 | 2025 |
| Revenue | $422 | $142 |
| Cost of sales | (11) | (54) |
| **Gross profit** | **411** | **88** |
| Research and development costs | (9122) | (20813) |
| General and administrative expenses | (7026) | (7684) |
| **Operating loss** | **(15737)** | **(28409)** |
| Foreign currency gain/(loss), net | (482) | (3769) |
| Other income, net | 571 | 969 |
| Benefit from R&D credit | 691 | 2679 |
| **Loss before income tax expense** | **(14957)** | **(28530)** |
| Income tax expense | - | - |
| **Net Loss** | $**(14957)** | $**(28530)** |
| **Loss per share (basic and diluted)** | $(0.11) | $(0.20) |
| **Weighted average shares outstanding (basic and diluted)** | 141702578 | 141678734 |

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