# EDGAR Filing Document

**Accession Number:** 0001401708
**File Stem:** 0001401708-23-000055
**Filing Date:** 2023-2
**Character Count:** 30700
**Document Hash:** 1c2754da133fe0e39b5ad2c4d0ab9802
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001401708-23-000055.hdr.sgml**: 20230228

**ACCESSION NUMBER**: 0001401708-23-000055

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 4

**FILED AS OF DATE**: 20230228

**DATE AS OF CHANGE**: 20230228

**EFFECTIVENESS DATE**: 20230228

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** NanoString Technologies Inc
- **CENTRAL INDEX KEY:** 0001401708
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **IRS NUMBER:** 200094687
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-270120
- **FILM NUMBER:** 23686263

**BUSINESS ADDRESS:**
- **STREET 1:** 530 FAIRVIEW AVENUE NORTH
- **CITY:** SEATTLE
- **STATE:** WA
- **ZIP:** 98109
- **BUSINESS PHONE:** 206-378-6266

**MAIL ADDRESS:**
- **STREET 1:** 530 FAIRVIEW AVENUE NORTH
- **CITY:** SEATTLE
- **STATE:** WA
- **ZIP:** 98109

**As filed with the Securities and Exchange Commission on February 28, 2023**

**Registration No. 333-**

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**FORM S-8**

**REGISTRATION STATEMENT**

***Under***

***The Securities Act of 1933***

**NANOSTRING TECHNOLOGIES, INC.**

**(Exact name of Registrant as specified in its charter)**

---

| | |
|:---|:---|
| **Delaware** | **20-0094687** |
| **(State or other jurisdiction of<br>incorporation or organization)** | **(I.R.S. Employer<br>Identification No.)** |
| **530 Fairview Avenue North**<br>**Seattle, Washington 98109**<br>**(206) 378-6266**<br>**(Address of principal executive offices, including zip code)** | **530 Fairview Avenue North**<br>**Seattle, Washington 98109**<br>**(206) 378-6266**<br>**(Address of principal executive offices, including zip code)** |

---

---

| |
|:---|
| **2018 Inducement Equity Incentive Plan** |
| **2013 Employee Stock Purchase Plan** |
| **(Full title of the plan)** |

---

**R. Bradley Gray<br>President and Chief Executive Officer<br>530 Fairview Avenue North<br>Seattle, Washington 98109<br>(206) 378-6266<br>(Name, address and telephone number, including area code, of agent for service)**

---

| | |
|:---|:---|
|  ***Copies to:*** |  ***Copies to:*** |
| **Patrick J. Schultheis<br>Michael Nordtvedt<br>Bryan D. King<br>Wilson Sonsini Goodrich & Rosati,<br>Professional Corporation<br>701 Fifth Avenue, Suite 5100<br>Seattle, Washington 98104<br>(206) 883-2500** | **Kathryn Surace-Smith<br>Senior Vice President, Human Resources and Legal Affairs<br>530 Fairview Avenue North<br>Seattle, Washington 98109<br>(206) 378-6266** |

---

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer" "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | 🗷 | Accelerated filer | ◻ |
| Non-accelerated filer | ◻ | Smaller reporting company | ◻ |
| | | Emerging growth company | ◻ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ◻

------

**EXPLANATORY NOTE** 

This Registration Statement on Form S-8 (the "Registration Statement") is filed by NanoString Technologies, Inc. (the "Registrant") for the purpose of registering (i) 175,000 shares of common stock of the Registrant reserved for issuance under the NanoString Technologies, Inc. 2018 Inducement Equity Incentive Plan; and (ii) 281,250 shares of common stock of the Registrant reserved for issuance under the NanoString Technologies, Inc. 2013 Employee Stock Purchase Plan.

**PART I**

**INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS**

The information specified in Item 1 and Item 2 of Part I of Form S-8 is omitted from this Registration Statement on Form S-8 (the "Registration Statement") in accordance with the provisions of Rule 428 under the Securities Act of 1933, as amended (the "Securities Act"), and the introductory note to Part I of Form S-8. The documents containing the information specified in Part I of Form S-8 will be delivered to the participants in the equity benefit plans covered by this Registration Statement as specified by Rule 428(b)(1) under the Securities Act.

**PART II**

**INFORMATION REQUIRED IN REGISTRATION STATEMENT**

---

| | |
|:---|:---|
| **Item 3.** | **Incorporation of Documents by Reference.** |

---

The following documents previously filed with the Securities and Exchange Commission (the "Commission") are hereby incorporated by reference:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1)The Registrant's <u>[Annual Report on Form](https://www.sec.gov/ix?doc=/Archives/edgar/data/0001401708/000140170823000052/nstg-20221231.htm)[10-K](https://www.sec.gov/ix?doc=/Archives/edgar/data/0001401708/000140170823000052/nstg-20221231.htm)</u> for the fiscal year ended December 31, 2022, filed with the Commission on February 28, 2023;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2)All other reports filed with the Commission pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended (the "**Act**"), since the end of the fiscal year covered by the Registrant's Annual Report referred to in (1) above; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3)The description of the Registrant's common stock contained in the Registration Statement on <u>[Form 8-A12B](https://www.sec.gov/Archives/edgar/data/1401708/000119312513267013/d557208d8a12b.htm)</u> (File No. 001-35980) filed with the Commission on June 21, 2013, pursuant to Section 12(b) of the Act, including any amendment or report filed for the purpose of updating such description.

All documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Act, prior to the filing of a post-effective amendment which indicates that all securities registered have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference in this Registration Statement and to be part hereof from the date of filing of such documents; *provided*, *however*, that documents or information deemed to have been furnished and not filed in accordance with the rules of the Commission shall not be deemed incorporated by reference into this Registration Statement. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently filed document which also is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.

**Item 4.&nbsp;&nbsp;&nbsp;&nbsp;Description of Securities.**

Not applicable.

**Item 5.&nbsp;&nbsp;&nbsp;&nbsp;Interests of Named Experts and Counsel.**

The validity of the shares of common stock offered hereby will be passed upon for the Registrant by Wilson Sonsini Goodrich & Rosati, Professional Corporation, Seattle, Washington. Individuals associated with Wilson Sonsini Goodrich & Rosati, Professional Corporation, hold shares of the Registrant's common stock representing in the aggregate less than 1.0% of the Registrant's outstanding shares of common stock.

------

**Item 6.&nbsp;&nbsp;&nbsp;&nbsp;Indemnification of Directors and Officers.** 

Section 145 of the Delaware General Corporation Law empowers a corporation to indemnify its directors and officers and to purchase insurance with respect to liability arising out of their capacity or status as directors and officers, provided that the person acted in good faith and in a manner the person reasonably believed to be in its best interests, and, with respect to any criminal action, had no reasonable cause to believe the person's actions were unlawful. The Delaware General Corporation Law further provides that the indemnification permitted thereunder shall not be deemed exclusive of any other rights to which the directors and officers may be entitled under the corporation's bylaws, any agreement, a vote of stockholders or otherwise. The certificate of incorporation of the Registrant provides for the indemnification of the Registrant's directors and officers to the fullest extent permitted under the Delaware General Corporation Law. In addition, the bylaws of the Registrant require the Registrant to fully indemnify any person who was or is a party or is threatened to be made a party to any threatened, pending or completed action, suit or proceeding (whether civil, criminal, administrative or investigative) by reason of the fact that such person is or was a director, or officer of the Registrant, or is or was a director or officer of the Registrant serving at the Registrant's request as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise, against expenses (including attorney's fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by such person in connection with such action, suit or proceeding, to the fullest extent permitted by applicable law.

Section 102(b)(7) of the Delaware General Corporation Law permits a corporation to provide in its certificate of incorporation that a director of the corporation shall not be personally liable to the corporation or its stockholders for monetary damages for breach of fiduciary duty as a director, except (1) for any breach of the director's duty of loyalty to the corporation or its stockholders, (2) for acts or omissions not in good faith or which involve intentional misconduct or a knowing violation of law, (3) for payments of unlawful dividends or unlawful stock repurchases, redemptions or other distributions or (4) for any transaction from which the director derived an improper personal benefit. The Registrant's certificate of incorporation provides that the Registrant's directors shall not be personally liable to the Registrant or its stockholders for monetary damages for breach of fiduciary duty as a director and that if the Delaware General Corporation Law is amended to authorize corporate action further eliminating or limiting the personal liability of directors, then the liability of the Registrant's directors shall be eliminated or limited to the fullest extent permitted by the Delaware General Corporation Law, as so amended.

Section 174 of the Delaware General Corporation Law provides, among other things, that a director who willfully or negligently approves of an unlawful payment of dividends or an unlawful stock purchase or redemption may be held liable for such actions. A director who was either absent when the unlawful actions were approved, or dissented at the time, may avoid liability by causing his or her dissent to such actions to be entered in the books containing minutes of the meetings of the board of directors at the time such action occurred or immediately after such absent director receives notice of the unlawful acts.

As permitted by the Delaware General Corporation Law, the Registrant has entered into separate indemnification agreements with each of the Registrant's directors and certain of the Registrant's officers which require the Registrant, among other things, to indemnify them against certain liabilities which may arise by reason of their status as directors, officers or certain other employees.

The Registrant maintains insurance policies under which its directors and officers are insured, within the limits and subject to the limitations of those policies, against certain expenses in connection with the defense of, and certain liabilities which might be imposed as a result of, actions, suits or proceedings to which they are parties by reason of being or having been directors or officers. The coverage provided by these policies may apply whether or not the Registrant would have the power to indemnify such person against such liability under the provisions of the Delaware General Corporation Law.

These indemnification provisions and the indemnification agreements entered into between the Registrant and the Registrant's officers and directors may be sufficiently broad to permit indemnification of the Registrant's officers and directors for liabilities (including reimbursement of expenses incurred) arising under the Securities Act of 1933.

**Item 7.&nbsp;&nbsp;&nbsp;&nbsp;Exemption from Registration Claimed.** 

Not applicable.

------

---

| | |
|:---|:---|
| **Item 8.** | **Exhibits** |

---

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | | | **Incorporated by Reference** | **Incorporated by Reference** | **Incorporated by Reference** |
| **Exhibit<br>Number** | **Exhibit Description** | **Form** | **File No.** | **Exhibit** | **Filing Date** |
| 4.1 | <u>[Specimen Common Stock Certificate of the Registrant.](http://www.sec.gov/Archives/edgar/data/1401708/000119312513256819/d428632dex41.htm)</u> | S-1/A | 333-188704 | 4.1 | June 13, 2013 |
| 4.2 | <u>[2018 Inducement Equity Incentive Plan and related form agreements.](https://www.sec.gov/Archives/edgar/data/1401708/000140170823000052/nstg-2022ex108.htm)</u> | 10-K | 001-35980 | 10.8 | February 28, 2023 |
| 4.3 | <u>[Form of RSU Agreement under the 2018 Inducement Equity Incentive Plan.](https://www.sec.gov/Archives/edgar/data/1401708/000140170823000052/nstg-2022ex109.htm)</u> | 10-K | 001-35980 | 10.9 | February 28, 2023 |
| 4.4 | <u>[Form of Stock Option Agreement under the 2018 Inducement Equity Incentive Plan.](https://www.sec.gov/Archives/edgar/data/1401708/000140170823000052/nstg-2022ex1010.htm)</u> | 10-K | 001-35980 | 10.10 | February 28, 2023 |
| 4.5 | <u>[2013 Employee Stock Purchase Plan.](http://www.sec.gov/Archives/edgar/data/1401708/000119312513256819/d428632dex109.htm)</u> | S-1/A | 333-188704 | 10.9 | June 13, 2013 |
| 5.1 | <u>[Opinion of Wilson Sonsini Goodrich & Rosati, Professional Corporation](nstg-ex51123122.htm)</u>. |  |  |  |  |
| 23.1 | <u>[Consent of](nstg-ex231123122.htm)[Independent Registered Public Accounting Firm.](nstg-ex231123122.htm)</u> |  |  |  |  |
| 23.2 | <u>[Consent of Wilson Sonsini Goodrich & Rosati, Professional Corporation (contained in Exhibit 5.1 hereto).](nstg-ex51123122.htm)</u> |  |  |  |  |
| 24.1 | <u>[Power of Attorney (contained on signature page hereto).](#i907d50fedbd04b54a57922136f819937_13)</u> |  |  |  |  |
| 107 | <u>[Filing Fee Table](nstg-ex107123122.htm)</u> |  |  |  |  |

---

------

**Item 9.&nbsp;&nbsp;&nbsp;&nbsp;Undertakings.**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A. The undersigned Registrant hereby undertakes:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) To include any prospectus required by Section 10(a)(3) of the Securities Act of 1933;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) To reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the Registration Statement. Notwithstanding the foregoing, any increase or decrease in the volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective Registration Statement;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) To include any material information with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such information in the Registration Statement.

Provided, however, that paragraphs (A)(1)(i) and (A)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in this Registration Statement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new Registration Statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;B. The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act of 1933, each filing of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the Registration Statement shall be deemed to be a new Registration Statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;C. Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the Registrant pursuant to the provisions described under "Item 6-Indemnification of Directors and Officers," or otherwise, the Registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act of 1933 and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel, the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act of 1933 and will be governed by the final adjudication of such issue.

------

**SIGNATURES**

Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Seattle, State of Washington, on February 28, 2023.

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| | |
|:---|:---|
| **NANOSTRING TECHNOLOGIES, INC.** | **NANOSTRING TECHNOLOGIES, INC.** |
| By: | /s/ R. Bradley Gray |
|  | R. Bradley Gray |
|  | President and Chief Executive Officer |

---

**POWER OF ATTORNEY**

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints R. Bradley Gray and K. Thomas Bailey as his or her true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities (including his or her capacity as a director and/or officer of NanoString Technologies, Inc.) to sign the Registration Statement on Form S-8 of NanoString Technologies, Inc., and any or all amendments (including post-effective amendments) thereto, and to file the same, with all exhibits thereto and all other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as they, he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents or any of them, or their, his, or her substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement on Form S-8 has been signed by the following persons in the capacities and on the date indicated.

---

| | | |
|:---|:---|:---|
| **<u>Signature</u>** | **<u>Title</u>** | **<u>Date</u>** |
| /s/ R. Bradley Gray | President, Chief Executive Officer and Director (Principal Executive Officer) | February 28, 2023 |
| R. Bradley Gray | President, Chief Executive Officer and Director (Principal Executive Officer) | February 28, 2023 |
| /s/ K. Thomas Bailey | Chief Financial Officer (Principal Accounting and Financial Officer) | February 28, 2023 |
| K. Thomas Bailey | Chief Financial Officer (Principal Accounting and Financial Officer) | February 28, 2023 |
| /s/ William D. Young | Chairman of the Board of Directors | February 28, 2023 |
| William D. Young | Chairman of the Board of Directors | February 28, 2023 |
| /s/ Elisha W. Finney | Director | February 28, 2023 |
| Elisha W. Finney | Director | February 28, 2023 |
| /s/ Teresa Foy | Director | February 28, 2023 |
| Teresa Foy | Director | February 28, 2023 |
| /s/ Janet George | Director | February 28, 2023 |
| Janet George | Director | February 28, 2023 |
| /s/ Kirk D. Malloy | Director | February 28, 2023 |
| Kirk D. Malloy | Director | February 28, 2023 |
| /s/ Gregory Norden | Director | February 28, 2023 |
| Gregory Norden | Director | February 28, 2023 |
| /s/ Dana Rollison | Director | February 28, 2023 |
| Dana Rollison | Director | February 28, 2023 |
| /s/ Charles P. Waite | Director | February 28, 2023 |
| Charles P. Waite | Director | February 28, 2023 |

---

## Ex-Filing

**Exhibit 107**

**Calculation of Filing Fee Table**

**Form S-8**

(Form Type)

**NanoString Technologies, Inc.**

(Exact Name of Registrant as Specified in its Charter)

<u>Table 1: Newly Registered Securities</u>

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| | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| **Security Type** | **Security Class Title** | **Fee Calculation Rule** | **Amount**<br>**Registered** <sup>(1)(2)</sup> | **Amount**<br>**Registered** <sup>(1)(2)</sup> | **Proposed<br>Maximum<br>Offering Price<br>Per Unit** | **Proposed<br>Maximum<br>Offering Price<br>Per Unit** | **Proposed<br>Maximum<br>Aggregate<br>Offering Price** | **Fee Rate** | **Amount of<br>Registration Fee** |
| Equity | Common Stock, $0.0001 par value per share, reserved for issuance pursuant to the 2013 Employee Stock Purchase Plan | Other<sup>(4)</sup> | 281250 | <sup>(3)</sup> | $8.31 | <sup>(4)</sup> | $2337188 | $0.0001102 | $258 |
| Equity | Common Stock, $0.0001 par value per share, reserved for issuance pursuant to the 2018 Inducement Equity Incentive Plan | Other<sup>(6)</sup> | 175000 | <sup>(5)</sup> | $9.77 | <sup>(6)</sup> | $1709750 | $0.0001102 | $189 |
| **Total Offering Amounts** | **Total Offering Amounts** | **Total Offering Amounts** | **Total Offering Amounts** | **Total Offering Amounts** | **Total Offering Amounts** | **Total Offering Amounts** | **Total Offering Amounts** | **Total Offering Amounts** | $447 |
| **Total Fee Offsets** | **Total Fee Offsets** | **Total Fee Offsets** | **Total Fee Offsets** | **Total Fee Offsets** | **Total Fee Offsets** | **Total Fee Offsets** | **Total Fee Offsets** | **Total Fee Offsets** | $— |
| **Net Fee Due** | **Net Fee Due** | **Net Fee Due** | **Net Fee Due** | **Net Fee Due** | **Net Fee Due** | **Net Fee Due** | **Net Fee Due** | **Net Fee Due** | $447 |

---

(1)Represents shares of common stock, par value $0.0001 per share ("Common Stock") of NanoString Technologies, Inc. (the "Registrant") available for issuance pursuant to awards granted pursuant to the Registrant's 2013 Employee Stock Purchase Plan (the "2013 ESPP") and 2018 Inducement Equity Incentive Plan (the "2018 Plan"). In addition, pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement shall also cover any additional shares of the Registrant's Common Stock that become issuable under the 2013 ESPP or 2018 Plan by reason of an event such as any stock split, stock dividend, recapitalization or similar transaction effected without receipt of consideration that increases the number of the Registrant's outstanding shares of Common Stock.

(2)For the sole purpose of calculating the registration fee, the number of shares to be registered under this Registration Statement has been broken down into two subtotals.

(3)Represents 281,250 additional shares of common stock available for issuance as a result of the annual evergreen increase pursuant to the 2013 ESPP.

(4)Estimated in accordance with Rules 457(c) and (h) of the Securities Act solely for the purposes of calculating the registration fee on the basis of 85% of $9.77 per share, which represents the average of the high and low prices of the Registrant's Common Stock on February 23, 2023, as reported on The Nasdaq Global Market. Pursuant to the 2013 ESPP, the purchase price of the shares of the Registrant's Common Stock reserved for issuance thereunder will be 85% of the lower of the fair market value of the Common Stock on the first trading day of the offering period or on the last day of the offering period.

(5)Represents 175,000 additional shares of Common Stock available for issuance as a result of the annual evergreen increase pursuant to the 2018 Plan.

(6)Estimated in accordance with Rules 457(c) and (h) of the Securities Act solely for purposes of calculating the registration fee on the basis of $9.77 per share, which represents the average of the high and low prices of the Registrant's Common Stock on February 23, 2023, as reported on The Nasdaq Global Market.

------

<u>Table 2: Fee Offset Claims and Sources</u>

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| | | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | **Registrant or Filer Name** | **Form or Filing Type** | **File Number** | **Initial Filing Date** | **Filing Date** | **Fee Offset Claimed** | **Security Type Associated with Fee Offset Claimed** | **Unsold Securities Associated with Fee Offset Claimed** | **Unsold Aggregate Offering Amount Associated with Fee Offset Claimed** | **Fee Paid with Fee Offset Source** |
| **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** |
| Fee Off-set Claims |  |  |  |  |  |  |  |  |  |  |
| Fee Off-set Sources |  |  |  |  |  |  |  |  |  |  |

---

## Exhibit 5.1

**Exhibit 5.1**

February 28, 2023

NanoString Technologies, Inc.

530 Fairview Avenue North

Seattle, Washington 98109

**Re: Registration Statement on Form S-8**

Ladies and Gentlemen:

We have examined the Registration Statement on Form S-8 (the "Registration Statement") to be filed by NanoString Technologies, Inc., a Delaware corporation, with the Securities and Exchange Commission on or about the date hereof, in connection with the registration under the Securities Act of 1933, as amended, of an aggregate of 456,250 shares of your common stock, par value $0.0001 per share (the "Shares"), consisting of (i) 281,250 shares of common stock to be issued under the 2013 Employee Stock Purchase Plan; and (ii) 175,000 shares of common stock to be issued under the 2018 Inducement Equity Incentive Plan (collectively, the "Plans"). As your legal counsel, we have reviewed the actions proposed to be taken by you in connection with the issuance and sale of the Shares to be issued under the Plans.

It is our opinion that the Shares, when issued and sold in the manner referred to in the Plans and pursuant to the agreements that accompany the Plans, will be legally and validly issued, fully paid and nonassessable.

We consent to the use of this opinion as an exhibit to the Registration Statement, and further consent to the use of our name wherever appearing in the Registration Statement and any amendments thereto.

---

| |
|:---|
| Very truly yours, |
| WILSON SONSINI GOODRICH & ROSATI |
| Professional Corporation |
| /s/ Wilson Sonsini Goodrich & Rosati, P.C. |

---

## Exhibit 23.1

**Exhibit 23.1**

**Consent of Independent Registered Public Accounting Firm**

We consent to the incorporation by reference in the Registration Statement (Form S-8) pertaining to the 2018 Inducement Equity Incentive Plan and the 2013 Employee Stock Purchase Plan of NanoString Technologies, Inc., of our reports dated February 28, 2023, with respect to the consolidated financial statements of NanoString Technologies, Inc., and the effectiveness of internal control over financial reporting of NanoString Technologies, Inc. included in its Annual Report (Form 10-K) for the year ended December 31, 2022, filed with the Securities and Exchange Commission.

/s/ Ernst & Young LLP

Seattle, Washington

February 28, 2023

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