# EDGAR Filing Document

**Accession Number:** 0001662244
**File Stem:** 0000950170-23-009471
**Filing Date:** 2023-3
**Character Count:** 20238
**Document Hash:** fc226a90fde07f02249ddb8328b3bc52
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000950170-23-009471.hdr.sgml**: 20230323

**ACCESSION NUMBER**: 0000950170-23-009471

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 13

**CONFORMED PERIOD OF REPORT**: 20230323

**ITEM INFORMATION**: Results of Operations and Financial Condition

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20230323

**DATE AS OF CHANGE**: 20230323

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Cyteir Therapeutics, Inc.
- **CENTRAL INDEX KEY:** 0001662244
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 455429901
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-40499
- **FILM NUMBER:** 23756156

**BUSINESS ADDRESS:**
- **STREET 1:** 128 SPRING STREET
- **STREET 2:** BUILDING A, SUITE 510
- **CITY:** LEXINGTON
- **STATE:** MA
- **ZIP:** 02421
- **BUSINESS PHONE:** 857-285-4140

**MAIL ADDRESS:**
- **STREET 1:** 128 SPRING STREET
- **STREET 2:** BUILDING A, SUITE 510
- **CITY:** LEXINGTON
- **STATE:** MA
- **ZIP:** 02421

?xml version="1.0" encoding="ASCII"? 8-K

**UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549**

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**FORM** 8-K

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**CURRENT REPORT**

**Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934**

**Date of Report (Date of earliest event reported):** March 23, 2023<br>

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Cyteir Therapeutics, Inc.

**(Exact name of Registrant as Specified in Its Charter)**

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| | | |
|:---|:---|:---|
| Delaware | 001-40499 | 45-5429901 |
| **(State or Other Jurisdiction<br>of Incorporation)** | **(Commission File Number)** | **(IRS Employer<br>Identification No.)** |
| 128 Spring St, Building A**,** Suite 510 |  |  |
| Lexington**,** Massachusetts |  | 02421 |
| **(Address of Principal Executive Offices)** |  | **(Zip Code)** |

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**Registrant's Telephone Number, Including Area Code:** 857 285-4140<br>

**Not Applicable**<br>

**(Former Name or Former Address, if Changed Since Last Report)**

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Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

**Securities registered pursuant to Section 12(b) of the Act:**

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| | | |
|:---|:---|:---|
| **<br>Title of each class** | **Trading<br>Symbol(s)** | **<br>Name of each exchange on which registered** |
| Common Stock, $0.001 par value per share | CYT | The Nasdaq Global Select Market |

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Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging growth company ☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

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**Item 2.02 Results of Operations and Financial Condition.**

On March 23, 2023, Cyteir Therapeutics, Inc. (the "Company") issued a press release announcing the Company's financial results for the year ended December 31, 2022. A copy of this press release is furnished as Exhibit 99.1 and is incorporated herein by reference.

The information in this Form 8-K (including Exhibit 99.1 attached hereto) is being furnished and shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference into any filing by the Company, under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such filing.

**Item 9.01 Financial Statements and Exhibits.**

(d) Exhibits

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| | |
|:---|:---|
| **Exhibit**<br>**No.** | **Description** |
| 99.1 | [<u>Press release issued by Cyteir Therapeutics, Inc. on March 23, 2023</u>](cyt-ex99_1.htm) |
| 104 | Cover Page Interactive Data File (embedded within the inline XBRL document) |

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**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

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| | | | |
|:---|:---|:---|:---|
|  |  |  | **CYTEIR THERAPEUTICS, INC.** |
| Date: | March 23, 2023 | By:  | /s/ Adam M. Veness, Esq. |
|  |  |  | Name: Adam M. Veness, Esq.<br>Title: General Counsel |

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## Ex-99

**Exhibit 99.1**

**Cyteir Therapeutics Reports Fourth Quarter and Full Year 2022 Financial Results and Operational Highlights**

-Initial data from Phase 1 combination with capecitabine in advanced ovarian cancer are expected in mid-2023

-Dose for the Phase 1 combination trials identified as 400mg daily

-Ended 2022 with approximately $147 million in cash; Projected cash runway into 2026

LEXINGTON, MA — March 23, 2022 — Cyteir Therapeutics, Inc. ("Cyteir") (Nasdaq: CYT), a clinical stage oncology company, today reported financial results for the fourth quarter and full year ended December 31, 2022 and provided an update on recent operational highlights.

"We continue to be encouraged by the early clinical activity of CYT-0851 in ovarian cancer and are committed to bringing CYT-0851 to patients," said Markus Renschler, MD, President and Chief Executive Officer of Cyteir. "Our significant cash runway gives us the resources to focus our development on CYT-0851 and into a potentially registrational trial as early as the second half of 2024."

**Recent Updates to the CYT-0851 Clinical Program**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•In January, Cyteir reported encouraging preliminary clinical activity in the Phase 1 dose escalation cohorts with CYT-0851, an investigational oral monocarboxylate transporter inhibitor, in combination with capecitabine for the treatment of advanced ovarian cancer. Cyteir announced the prioritization of development of CYT-0851 in combination with capecitabine in advanced ovarian cancer and deferred development of additional indications with this combination. Cyteir plans to enroll up to an additional nine patients with advanced ovarian cancer in the capecitabine combination at the 400 mg CYT-0851 dose level. If supported by the data and regulatory feedback, Cyteir intends to pursue development and potential registration of CYT-0851 in combination with capecitabine as an all-oral treatment for platinum resistant ovarian cancer. Preliminary data on the combination with capecitabine are expected to be disclosed in mid-2023.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Enrollment in the Phase 1 dose escalation cohorts of CYT-0851 in combination with gemcitabine in solid tumors continues. This combination is currently being evaluated at 300 mg of CYT-0851 in combination with gemcitabine, and if deemed tolerable, will advance to 400 mg of CYT-0851 in combination with gemcitabine. Preliminary data from the Phase 1 dose escalation cohorts of CYT-0851 in combination with gemcitabine are expected to be disclosed in mid-2023.

**Recent Business Updates**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•In conjunction with the prioritization of the clinical plan for CYT-0851, Cyteir also ceased all discovery projects focused on identifying inhibitors of DNA damage repair. Cyteir is pursuing out licensing of its preclinical pipeline.

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**Fourth Quarter and Full Year 2022 Financial Results**

<u>Cash and cash equivalents</u>: Cash and cash equivalents as of December 31, 2022 were $147.1 million, which are expected to fund planned operations into 2026.

<u>Research and development (R&D) expenses:</u> R&D expenses were $7.5 million for the fourth quarter of 2022 versus $8.3 million for the same period in 2021 and $34.6 million for the full year 2022 versus $31.0 million for full year 2021. The year-over-year increase in R&D spending was due primarily to increased headcount and research activity. The decrease in fourth quarter 2022 R&D spending versus 2021 was due to lower clinical trial costs.

<u>General and administrative (G&A) expenses</u>: G&A expenses were $2.6 million for the fourth quarter of 2022 compared to $3.6 million for the same period in 2021 and $13.5 million for the full year 2022 compared to $11.3 million for full year 2021. The year-over-year increase in full year 2022 G&A expenses was primarily due to employee-related costs, as well as other administrative expenses associated with company growth and operating as a public company. The decrease in fourth quarter 2022 G&A spending versus 2021 was due to lower employee-related costs and other administrative expenses.

<u>Net loss</u>: Net loss was $8.8 million, or $0.25 per share, in the fourth quarter of 2022 compared to $11.8 million, or $0.34 per share, for the same period in 2021. For the full year 2022, net loss was $46.1 million, or $1.31 per share compared to $42.1 million, or $2.16 per share for full year 2021.

**About Cyteir Therapeutics, Inc.**

Cyteir is a clinical-stage oncology company that is focused on the development of CYT-0851, an oral investigational drug that inhibits monocarboxylate transporters. Cyteir's current priority in CYT-0851 development is in combination with capecitabine and gemcitabine in a Phase 1/2 clinical study, including patients with advanced ovarian cancer. Follow Cyteir on social media: LinkedIn and Twitter and at www.cyteir.com.

**Forward-Looking Statements**

This press release contains "forward-looking statements" about Cyteir's strategy, future plans, and prospects, including statements regarding the development of Cyteir's compounds and potential expansion opportunities, regulatory strategy, and path for Cyteir's compounds, the expected timing and reporting of results of Cyteir's preclinical and clinical studies, and Cyteir's expected cash runway. The words "anticipate," "believe," "continue," "could," "estimate," "expect," "intend," "likely," "may," "might," "plan," "potential," "project," "seek," "will," "would," and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words.These forward-looking statements include: the benefits and potential impact of our portfolio prioritization; expected timing to receive clinical data from current ongoing clinical studies; expected cost savings from our prioritization and reduction in force; and our expected extended cash runway.

Actual results could differ materially from those included in the forward-looking statements due to various factors, risks and uncertainties, including, but not limited to: that Cyteir's clinical trials may fail to demonstrate adequately the safety and efficacy of CYT-0851; that preclinical testing of CYT-0851 may not be predictive of the results or success of clinical trials; that the clinical development of CYT-0851 may be

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delayed or otherwise take longer and/or cost more than planned; that Cyteir may be unable to initiate, enroll or complete clinical development of CYT-0851; that the continuing global outbreak of COVID-19 (including any resurgences or variants) may result in development or manufacturing delays, supply shortages, or shortages of qualified healthcare personnel; that synthetic lethality, as an emerging class of precision medicine targets, could result in negative perceptions of the efficacy, safety or tolerability of this class of targets, which could adversely affect our ability to conduct our business, advance our drug candidates or obtain regulatory approvals; and that Cyteir's compounds may not receive regulatory approvals or become commercially successful products. These and other risks and uncertainties are identified under the heading "Risk Factors" in Cyteir's most recent Annual Report on Form 10-K and other filings Cyteir has made and may make with the Securities and Exchange Commission ("SEC") in the future, available on the SEC's website at www.sec.gov.

The forward-looking statements contained in this press release are based on management's current views, plans, estimates, assumptions, and projections with respect to future events, and Cyteir does not undertake and specifically disclaims any obligation to update any forward-looking statements.

**CONTACT:**

Cyteir Investor Relations

857-285-4140

<u>ir@cyteir.com</u>

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| | | | | |
|:---|:---|:---|:---|:---|
| **Cyteir Therapeutics Inc** | **Cyteir Therapeutics Inc** | **Cyteir Therapeutics Inc** | **Cyteir Therapeutics Inc** | **Cyteir Therapeutics Inc** |
| **Condensed consolidated statements of operations** | **Condensed consolidated statements of operations** | **Condensed consolidated statements of operations** | **Condensed consolidated statements of operations** | **Condensed consolidated statements of operations** |
| **(in thousands, except share and per share amounts)<br>(unaudited)** | **(in thousands, except share and per share amounts)<br>(unaudited)** | **(in thousands, except share and per share amounts)<br>(unaudited)** | **(in thousands, except share and per share amounts)<br>(unaudited)** | **(in thousands, except share and per share amounts)<br>(unaudited)** |
|  | **Three Months Ended December 31,** | **Three Months Ended December 31,** | **Years Ended December 31,** | **Years Ended December 31,** |
|  | **2022** | **2021** | **2022** | **2021** |
| Operating expenses: |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Research and development | $7470 | $8255 | $34624 | $30959 |
| &nbsp;&nbsp;&nbsp;&nbsp;General and administrative | 2583 | 3607 | 13546 | 11300 |
| &nbsp;&nbsp;&nbsp;&nbsp; Total operating expenses | 10053 | 11862 | 48170 | 42259 |
| Loss from operations | (10053) | (11862) | (48170) | (42259) |
| Other income (expense): |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Other income (expense) | 1260 | 47 | 2109 | 133 |
| &nbsp;&nbsp;&nbsp;&nbsp; Total other income (expense) | 1260 | 47 | 2109 | 133 |
| Net loss | $(8793) | $(11815) | $(46061) | $(42126) |
| Net loss per share—basic and diluted | $(0.25) | $(0.34) | $(1.31) | $(2.16) |
| Weighted-average common stock outstanding—basic and diluted | 35375849 | 35136168 | 35272831 | 19499292 |
| Research and development expenses for the fourth quarter and full year-ended December 31, 2022 include stock-based compensation expense of $0.5 million and $1.9 million, respectively, compared to $0.4 million and $1.2 million, respectively, in the corresponding periods of 2021. General and administrative expenses for the fourth quarter and full year-ended December 31, 2022 include stock-based compensation expense of $0.4 million and $2.8 million, respectively, compared to $0.8 million and $2.3 million, respectively, in the corresponding periods of 2021. | Research and development expenses for the fourth quarter and full year-ended December 31, 2022 include stock-based compensation expense of $0.5 million and $1.9 million, respectively, compared to $0.4 million and $1.2 million, respectively, in the corresponding periods of 2021. General and administrative expenses for the fourth quarter and full year-ended December 31, 2022 include stock-based compensation expense of $0.4 million and $2.8 million, respectively, compared to $0.8 million and $2.3 million, respectively, in the corresponding periods of 2021. | Research and development expenses for the fourth quarter and full year-ended December 31, 2022 include stock-based compensation expense of $0.5 million and $1.9 million, respectively, compared to $0.4 million and $1.2 million, respectively, in the corresponding periods of 2021. General and administrative expenses for the fourth quarter and full year-ended December 31, 2022 include stock-based compensation expense of $0.4 million and $2.8 million, respectively, compared to $0.8 million and $2.3 million, respectively, in the corresponding periods of 2021. | Research and development expenses for the fourth quarter and full year-ended December 31, 2022 include stock-based compensation expense of $0.5 million and $1.9 million, respectively, compared to $0.4 million and $1.2 million, respectively, in the corresponding periods of 2021. General and administrative expenses for the fourth quarter and full year-ended December 31, 2022 include stock-based compensation expense of $0.4 million and $2.8 million, respectively, compared to $0.8 million and $2.3 million, respectively, in the corresponding periods of 2021. | Research and development expenses for the fourth quarter and full year-ended December 31, 2022 include stock-based compensation expense of $0.5 million and $1.9 million, respectively, compared to $0.4 million and $1.2 million, respectively, in the corresponding periods of 2021. General and administrative expenses for the fourth quarter and full year-ended December 31, 2022 include stock-based compensation expense of $0.4 million and $2.8 million, respectively, compared to $0.8 million and $2.3 million, respectively, in the corresponding periods of 2021. |

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| | | |
|:---|:---|:---|
| **Cyteir Therapeutics Inc** | **Cyteir Therapeutics Inc** | **Cyteir Therapeutics Inc** |
| **Condensed consolidated balance sheets** | **Condensed consolidated balance sheets** | **Condensed consolidated balance sheets** |
| **(in thousands, except share and per share amounts)<br>(unaudited)** | **(in thousands, except share and per share amounts)<br>(unaudited)** | **(in thousands, except share and per share amounts)<br>(unaudited)** |
|  | **December 31,** | **December 31,** |
|  | **2022** | **2021** |
| **Assets** |  |  |
| Current assets: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Cash and cash equivalents | $147120 | $189723 |
| &nbsp;&nbsp;&nbsp;&nbsp;Prepaid expenses and other current assets | 2089 | 3354 |
| &nbsp;&nbsp;&nbsp;&nbsp; Total current assets | $149209 | $193077 |
| &nbsp;&nbsp;&nbsp;&nbsp;Property and equipment, net | 1699 | 2055 |
| &nbsp;&nbsp;&nbsp;&nbsp;Other assets | 2324 | 256 |
| &nbsp;&nbsp;&nbsp;&nbsp; Total assets | $153232 | $195388 |
| **Liabilities and stockholders' equity** |  |  |
| Current liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Accounts payable | $1128 | $1785 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accrued expenses and other current liabilities | 4187 | 5726 |
| &nbsp;&nbsp;&nbsp;&nbsp; Total current liabilities | $5315 | $7511 |
| Deferred rent, net of current portion | - | 384 |
| Other long term liabilities | 1631 | 201 |
| &nbsp;&nbsp;&nbsp;&nbsp; Total liabilities | $6946 | $8096 |
| Commitments and contingencies (Note 12) |  |  |
| Stockholders' equity: |  |  |
| &nbsp;&nbsp;Preferred stock, $0.001 par value: 40,000,000 shares authorized<br>&nbsp;&nbsp;&nbsp;&nbsp;as of December 31, 2022 and 2021; no shares issued and outstanding<br>&nbsp;&nbsp;&nbsp;&nbsp;as of December 31, 2022 and 2021 | - | - |
| &nbsp;&nbsp;&nbsp;&nbsp;Common stock, $0.001 par value: 280,000,000 shares<br>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;authorized; 35,575,694 and 35,389,453 shares issued as of December 31, 2022<br>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;and 2021, respectively; 35,516,249 and 35,219,834 shares <br>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;outstanding as of December 31, 2022 and 2021, respectively | 35 | 35 |
| &nbsp;&nbsp;&nbsp;&nbsp;Additional paid-in capital | 284365 | 279310 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accumulated deficit | (138114) | (92053) |
| &nbsp;&nbsp;&nbsp;&nbsp; Total stockholders' equity | 146286 | 187292 |
| &nbsp;&nbsp;&nbsp;&nbsp; Total liabilities and stockholders' equity | $153232 | $195388 |

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