# EDGAR Filing Document

**Accession Number:** 0001002624
**File Stem:** 0001099263-25-003642
**Filing Date:** 2025-11
**Character Count:** 98053
**Document Hash:** 320ace31c5d370cb27676224ba5aa3c0
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001099263-25-003642.hdr.sgml**: 20251125

**ACCESSION NUMBER**: 0001099263-25-003642

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20250930

**FILED AS OF DATE**: 20251125

**DATE AS OF CHANGE**: 20251125

**PERIOD START**: 20251231

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** T. Rowe Price Health Sciences Fund, Inc.
- **CENTRAL INDEX KEY:** 0001002624

**ORGANIZATION NAME:**
- **EIN:** 521952906
- **STATE OF INCORPORATION:** MD
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-07381
- **FILM NUMBER:** 251521937

**BUSINESS ADDRESS:**
- **STREET 1:** 1307 POINT STREET
- **CITY:** BALTIMORE
- **STATE:** MD
- **ZIP:** 21231
- **BUSINESS PHONE:** 410-345-2000

**MAIL ADDRESS:**
- **STREET 1:** 1307 POINT STREET
- **CITY:** BALTIMORE
- **STATE:** MD
- **ZIP:** 21231

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** PRICE T ROWE HEALTH SCIENCES FUND INC
- **DATE OF NAME CHANGE:** 19980513

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** PRICE T ROWE HEALTH & LIFE SCIENCES FUND INC
- **DATE OF NAME CHANGE:** 19951023

## Series and Classes Contracts Data

### T. Rowe Price Health Sciences Fund, Inc. (Series ID: S000002088)

| Class ID   | Class Name                                 | Ticker Symbol   |
|:---|:---|:---|
| C000005456 | T. Rowe Price Health Sciences Fund, Inc.   | PRHSX           |
| C000169937 | T. Rowe Price Health Sciences Fund-I Class | THISX           |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** T. ROWE PRICE HEALTH SCIENCES FUND, INC.

- **b. Investment Company Act file number:** 811-07381

- **c. CIK number of Registrant:** 0001002624

- **d. LEI of Registrant:** 549300ELV6FPY6UQBJ78

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 1307 Point Street

  - **City:** Baltimore

  - **State:** MD

  - **Foreign country:** US

  - **Zip / Postal Code:** 21231

  - **Telephone number:** 410-345-2000

**Item A.2. Information about the Series.**

- **a. Name of Series:** T. Rowe Price Health Sciences Fund, Inc.

- **b. EDGAR series identifier (if any):** S000002088

- **c. LEI of Series:** 66LP7EMLZS5S33LWIH41

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2025-12-31

- **b. Date as of which information is reported:** 2025-09-30

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $11023189961.24

**Total Liabilities:** $8632599.56

**Net Assets:** $11014557361.68

**Assets Attributable to Miscellaneous Securities:** $446536673.10

**Cash Not Reported:** $30304.08

**Currency Risk Metrics (dv01):**

- 

**Credit Spread Risk - Investment Grade (dv01):**

- **3-Month:** 0.000000 | **1-Year:** 0.000000 | **5-Year:** 0.000000 | **10-Year:** 0.000000 | **30-Year:** 0.000000

**Credit Spread Risk - Non-Investment Grade (dv01):**

- **3-Month:** 0.000000 | **1-Year:** 0.000000 | **5-Year:** 0.000000 | **10-Year:** 0.000000 | **30-Year:** 0.000000

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000005456 | -1.31%               | 4.15%                | 2.15%                |
| Class ID C000169937 | -1.29%               | 4.17%                | 2.16%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $107935089.19            | $-247857937.86                             |
| Month 2  | $191038650.77            | $253799155.87                              |
| Month 3  | $91830342.38             | $140644710.52                              |

### Schedule of Portfolio Investments

| Name                                       | Title                                              | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| EXACT SCIENCES CMO MILESTONE PP            | - EXACT SCIENCES CMO MILESTONE PP                  | CUSIP: 000000000<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |   3726272 | NS      | $0.00         | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ABBVIE INC                                 | ABBVIE INC                                         | CUSIP: 00287Y109<br>LEI: FR5LCKFTG8054YNNRU85 | Long             | EC               | CORP              | US        |   1554481 | NS      | $359924530.74 | 3.27%             |  |  |  | No            |                  1 | On Loan: No      |
| ABIVAX SA-ADR                              | ABIVAX SA                                          | CUSIP: 00370M103<br>LEI: 969500D8TMNB184OJU95 | Long             | EC               | CORP              | FR        |    293858 | NS      | $24948544.20  | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| ACADIA PHARMACEUTICALS INC                 | ACADIA PHARMACEUTICALS INC                         | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |    380944 | NS      | $8129344.96   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| AFFINIVAX AFX3772 MILESTONE EVENT PP       | AFFINIVAX AFX3772 MILESTONE EVENT PP               | CUSIP: TC2HD0ET2<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   7349672 | NS      | $0.00         | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| AFFINIVAX EXPENSE FUND PP                  | AFFINIVAX EXPENSE FUND PP                          | CUSIP: TC929D1E2<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     12445 | NS      | $11823.17     | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| AFFINIVAX NEXT GEN PROD MILESTON EVNT PP   | AFFINIVAX NEXT GEN PROD MILESTON EVNT PP           | CUSIP: TC7BEY6E7<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   7349672 | NS      | $0.00         | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| AGIOS PHARMACEUTICALS INC                  | AGIOS PHARMACEUTICALS INC                          | CUSIP: 00847X104<br>LEI: 529900ONJHY8EOGYT555 | Long             | EC               | CORP              | US        |    774777 | NS      | $31099548.78  | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| AKERO THERAPEUTICS INC                     | AKERO THERAPEUTICS INC                             | CUSIP: 00973Y108<br>LEI: 549300SI3KG74LBE2955 | Long             | EC               | CORP              | US        |   1118053 | NS      | $53085156.44  | 0.48%             |  |  |  | No            |                  1 | On Loan: No      |
| Aktis Oncology SER B CVTPFD PP             | AKTIS ONCOLOGY SER B CVTPFD PP                     | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   2757866 | NS      | $11031464.00  | 0.10%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ALECTOR INC                                | ALECTOR INC                                        | CUSIP: 014442107<br>LEI: 549300Z8RQOIY1JMHC25 | Long             | EC               | CORP              | US        |   1589029 | NS      | $4703525.84   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| ALIGNMENT HEALTHCARE INC                   | ALIGNMENT HEALTHCARE INC                           | CUSIP: 01625V104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1525759 | NS      | $26624494.55  | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| ALKERMES PLC                               | ALKERMES PLC                                       | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | IE        |    756622 | NS      | $22698660.00  | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| ALLOGENE THERAPEUTICS INC                  | ALLOGENE THERAPEUTICS INC                          | CUSIP: 019770106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2611403 | NS      | $3238139.72   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| ALNYLAM PHARMACEUTICALS INC                | ALNYLAM PHARMACEUTICALS INC                        | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |    793687 | NS      | $361921272.00 | 3.29%             |  |  |  | No            |                  1 | On Loan: No      |
| ANNEXON INC                                | ANNEXON INC                                        | CUSIP: 03589W102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    245647 | NS      | $749223.35    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| APOGEE THERAPEUTICS INC                    | APOGEE THERAPEUTICS INC                            | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    505058 | NS      | $20065954.34  | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| ARBOR BIO SERIES B CVT PFD STOCK PP        | ARBOR BIO SERIES B CVT PFD STOCK PP                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    532759 | NS      | $2189639.49   | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ARBOR BIO SERIES C CVT PFD STOCK PP        | ARBOR BIO SERIES C CVT PFD STOCK PP                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    322096 | NS      | $1323814.56   | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ARCELLX INC                                | ARCELLX INC                                        | CUSIP: 03940C100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    371973 | NS      | $30538983.30  | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| ARGENX SE - ADR                            | ARGENX SE                                          | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |    683030 | NS      | $503775606.80 | 4.57%             |  |  |  | No            |                  1 | On Loan: No      |
| ARSENAL BIOSCIENCES SER C CVT PFD PP       | ARSENAL BIOSCIENCES SER C CVT PFD PP               | CUSIP: TC5YX3EI8<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    724394 | NS      | $13459240.52  | 0.12%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ASCENDIS PHARMA A/S - ADR                  | ASCENDIS PHARMA A/S                                | CUSIP: 04351P101<br>LEI: 549300B66JN3W3J8GH73 | Long             | EC               | CORP              | DK        |    836811 | NS      | $166366394.91 | 1.51%             |  |  |  | No            |                  1 | On Loan: No      |
| ASTRAZENECA PLC-SPONS ADR                  | ASTRAZENECA PLC                                    | CUSIP: 046353108<br>LEI: PY6ZZQWO2IZFZC3IOL08 | Long             | EC               | CORP              | GB        |   3283838 | NS      | $251936051.36 | 2.29%             |  |  |  | No            |                  1 | On Loan: No      |
| AURA BIOSCIENCES INC                       | AURA BIOSCIENCES INC                               | CUSIP: 05153U107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    310931 | NS      | $1921553.58   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| AVALYN PHARMA SER C-1 CVT PFD STOCK PP     | AVALYN PHARMA SER C-1 CVT PFD STOCK PP             | CUSIP: TC6KYIDL7<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   8436161 | NS      | $6717715.00   | 0.06%             |  |  |  | Yes           |                  3 | On Loan: No      |
| AVALYN PHARMA SER D CVT PFD STOCK PP       | AVALYN PHARMA SER D CVT PFD STOCK PP               | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1666360 | NS      | $1326922.47   | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| AVIDITY BIOSCIENCES INC                    | AVIDITY BIOSCIENCES INC                            | CUSIP: 05370A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2531865 | NS      | $110313358.05 | 1.00%             |  |  |  | No            |                  1 | On Loan: No      |
| AXSOME THERAPEUTICS INC                    | AXSOME THERAPEUTICS INC                            | CUSIP: 05464T104<br>LEI: 549300EXGR0XLRJEIB95 | Long             | EC               | CORP              | US        |    228942 | NS      | $27805005.90  | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| BEAM THERAPEUTICS INC                      | BEAM THERAPEUTICS INC                              | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    992930 | NS      | $24098411.10  | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| BEONE MEDICINES LTD                        | BEONE MEDICINES LTD                                | CUSIP: 000000000<br>LEI: 549300JFUK6FRD5MH739 | Long             | EC               | CORP              | CH        |   8015396 | NS      | $213876361.52 | 1.94%             |  |  |  | No            |                  2 | On Loan: No      |
| BEONE MEDICINES LTD-ADR                    | BEONE MEDICINES LTD                                | CUSIP: 07725L102<br>LEI: 549300JFUK6FRD5MH739 | Long             | EC               | CORP              | KY        |    155666 | NS      | $53035406.20  | 0.48%             |  |  |  | No            |                  1 | On Loan: No      |
| BETA BIONICS INC                           | BETA BIONICS INC                                   | CUSIP: 08659B102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    365202 | NS      | $7256563.74   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| BICARA THERAPEUTICS INC                    | BICARA THERAPEUTICS INC                            | CUSIP: 055477103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1089473 | NS      | $17202778.67  | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| BICYCLE THERAPEUTICS PLC-ADR               | BICYCLE THERAPEUTICS PLC                           | CUSIP: 088786108<br>LEI: 213800XKUI6R7GKC3E43 | Long             | EC               | CORP              | GB        |   1039244 | NS      | $8043748.56   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| BIO-RAD LABORATORIES-A                     | BIO-RAD LABORATORIES INC                           | CUSIP: 090572207<br>LEI: 549300ZC1GPV35XYDK53 | Long             | EC               | CORP              | US        |     44957 | NS      | $12605493.23  | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| BIO-TECHNE CORP                            | BIO-TECHNE CORP                                    | CUSIP: 09073M104<br>LEI: 54930073RLKQ51TILZ35 | Long             | EC               | CORP              | US        |    246780 | NS      | $13728371.40  | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| BIOGEN INC                                 | BIOGEN INC                                         | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |    128912 | NS      | $18057992.96  | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| BIOHAVEN LTD                               | BIOHAVEN LTD                                       | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | VG        |    820357 | NS      | $12313558.57  | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| BLUEJAY THERAPEUTICS SER C CVT PFD PP      | BLUEJAY THERAPEUTICS SER C CVT PFD PP              | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   2529000 | NS      | $10728776.70  | 0.10%             |  |  |  | Yes           |                  3 | On Loan: No      |
| BLUEJAY THERAPEUTICS SER C-1 CVT PFD PP    | BLUEJAY THERAPEUTICS SER C-1 CVT PFD PP            | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    173971 | NS      | $738037.17    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| BOSTON SCIENTIFIC CORP                     | BOSTON SCIENTIFIC CORP                             | CUSIP: 101137107<br>LEI: Y6ZDD9FP4P8JSSJMW954 | Long             | EC               | CORP              | US        |   2750886 | NS      | $268569000.18 | 2.44%             |  |  |  | No            |                  1 | On Loan: No      |
| BridgeBio Oncology Therapeutics Inc        | BRIDGEBIO ONCOLOGY THERAPEUTICS INC                | CUSIP: 107924102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    756093 | NS      | $8755556.94   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| BRIDGEBIO PHARMA INC                       | BRIDGEBIO PHARMA INC                               | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |    366926 | NS      | $19058136.44  | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| BRIGHTSPRING HEALTH SERVICES               | BRIGHTSPRING HEALTH SERVICES INC                   | CUSIP: 10950A106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2314250 | NS      | $68409230.00  | 0.62%             |  |  |  | No            |                  1 | On Loan: No      |
| Cabaletta Bio Common WTS 09/26 PP          | CABALETTA BIO COMMON WTS 09/26 PP                  | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1694355 | NS      | $0.00         | 0.00%             |  |  |  | Yes           |                  2 | On Loan: No      |
| CABALETTA BIO INC                          | CABALETTA BIO INC                                  | CUSIP: 12674W109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1132473 | NS      | $2649986.82   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| CAPSULE CORP SERIES 1-D CVT PFD STOCK      | CAPSULE CORP SERIES 1-D CVT PFD STOCK              | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    853213 | NS      | $1100644.77   | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| CAPSULE CORP SERIES E CVT PFD STOCK PP     | CAPSULE CORP SERIES E CVT PFD STOCK PP             | CUSIP: TC0YJ3TD4<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    906656 | NS      | $1169586.24   | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| CARDINAL HEALTH INC                        | CARDINAL HEALTH INC                                | CUSIP: 14149Y108<br>LEI: CCU46N3GJMF4OK4N7U60 | Long             | EC               | CORP              | US        |    401657 | NS      | $63044082.72  | 0.57%             |  |  |  | No            |                  1 | On Loan: No      |
| CARIS LIFE SCIENCES INC                    | CARIS LIFE SCIENCES INC                            | CUSIP: 142152107<br>LEI: 549300LX5LO78M5VPY43 | Long             | EC               | CORP              | US        |    299174 | NS      | $9050013.50   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| CELCUITY INC                               | CELCUITY INC                                       | CUSIP: 15102K100<br>LEI: 25490070W7UU7W2SEY87 | Long             | EC               | CORP              | US        |    441461 | NS      | $21808173.40  | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| CELLANOME SERIES A CVT PFD STOCK PP        | CELLANOME SERIES A CVT PFD STOCK PP                | CUSIP: TC13MXKE8<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1993387 | NS      | $14930468.63  | 0.14%             |  |  |  | Yes           |                  3 | On Loan: No      |
| CELLDEX THERAPEUTICS INC                   | CELLDEX THERAPEUTICS INC                           | CUSIP: 15117B202<br>LEI: 529900F018DMYWH38923 | Long             | EC               | CORP              | US        |    570981 | NS      | $14771278.47  | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| CENCORA INC                                | CENCORA INC                                        | CUSIP: 03073E105<br>LEI: AI8GXW8LG5WK7E9UD086 | Long             | EC               | CORP              | US        |    259553 | NS      | $81118099.09  | 0.74%             |  |  |  | No            |                  1 | On Loan: No      |
| CENTENE CORP                               | CENTENE CORP                                       | CUSIP: 15135B101<br>LEI: 549300Z7JJ4TQSQGT333 | Long             | EC               | CORP              | US        |    310900 | NS      | $11092912.00  | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| CENTESSA PHARMACEUTICALS-ADR               | CENTESSA PHARMACEUTICALS PLC                       | CUSIP: 152309100<br>LEI: 213800GIDAARDSKOI827 | Long             | EC               | CORP              | GB        |   2889134 | NS      | $70061499.50  | 0.64%             |  |  |  | No            |                  1 | On Loan: No      |
| CG ONCOLOGY INC                            | CG ONCOLOGY INC                                    | CUSIP: 156944100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    898108 | NS      | $36175790.24  | 0.33%             |  |  |  | No            |                  1 | On Loan: No      |
| NCHROMA BIO SER I CVT PFD STOCK PP         | CHROMA MEDICINE SER I CVT PFD STOCK PP             | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   7683800 | NS      | $7683800.00   | 0.07%             |  |  |  | Yes           |                  3 | On Loan: No      |
| CHROMACODE INC PP                          | CHROMACODE INC PP                                  | CUSIP: TC43UPY99<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       626 | NS      | $3029.71      | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Chromacode INC SER AA CVT PFD STK PP       | CHROMACODE INC SER AA CVT PFD STK PP               | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |     36845 | NS      | $178322.43    | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| CHUGAI PHARMACEUTICAL CO LTD               | CHUGAI PHARMACEUTICAL CO LTD                       | CUSIP: 000000000<br>LEI: 529900T9LAII161DCN95 | Long             | EC               | CORP              | JP        |    733300 | NS      | $32510495.80  | 0.30%             |  |  |  | No            |                  2 | On Loan: No      |
| CIGNA GROUP/THE                            | CIGNA GROUP/THE                                    | CUSIP: 125523100<br>LEI: 549300VIWYMSIGT1U456 | Long             | EC               | CORP              | US        |    622390 | NS      | $179403917.50 | 1.63%             |  |  |  | No            |                  1 | On Loan: No      |
| CLEAR LABS SER D CVT PFD STOCK PP          | CLEAR LABS SER D CVT PFD STOCK PP                  | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    379601 | NS      | $1183026.52   | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| CLEAR LABS SERIES C CVT PFD PP             | CLEAR LABS SERIES C CVT PFD PP                     | CUSIP: TC385IBS6<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   3830773 | NS      | $12119799.62  | 0.11%             |  |  |  | Yes           |                  3 | On Loan: No      |
| CLEERLY SER C CVT PFD STK PP               | CLEERLY SER C CVT PFD STK PP                       | CUSIP: TC1A1CZJ4<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    586029 | NS      | $6903421.62   | 0.06%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Climb Bio Inc                              | CLIMB BIO INC                                      | CUSIP: 28658R106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    392217 | NS      | $788356.17    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| COLOR HEALTH SR D CVT PFD STOCK PP         | COLOR HEALTH SER D CVT PFD STOCK PP                | CUSIP: TC1HL9RU8<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    296922 | NS      | $5697933.18   | 0.05%             |  |  |  | Yes           |                  3 | On Loan: No      |
| COLOR HEALTH SR D-1 CVT PFD STOCK PP       | COLOR HEALTH SERIES D-1 CVT PFD STOCK PP           | CUSIP: TC3KSMZE0<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    438696 | NS      | $5913622.08   | 0.05%             |  |  |  | Yes           |                  3 | On Loan: No      |
| COLOR HEALTH SERIES E CVT PFD STOCK PP     | COLOR HEALTH SERIES E CVT PFD STOCK PP             | CUSIP: TC4SC4HB5<br>LEI: N/A                  | Long             | EP               | CORP              | US        |     44149 | NS      | $1810109.00   | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| CRESCENT BIOPHARMA INC                     | CRESCENT BIOPHARMA INC                             | CUSIP: 000000000<br>LEI: 549300TZ84FFU2J2J459 | Long             | EC               | CORP              | KY        |    305040 | NS      | $3626925.60   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| CRINETICS PHARMACEUTICALS IN               | CRINETICS PHARMACEUTICALS INC                      | CUSIP: 22663K107<br>LEI: 549300Q1CNFXK5P31D28 | Long             | EC               | CORP              | US        |   1247774 | NS      | $51969787.10  | 0.47%             |  |  |  | No            |                  1 | On Loan: No      |
| CVS HEALTH CORP                            | CVS HEALTH CORP                                    | CUSIP: 126650100<br>LEI: 549300EJG376EN5NQE29 | Long             | EC               | CORP              | US        |   1420104 | NS      | $107061640.56 | 0.97%             |  |  |  | No            |                  1 | On Loan: No      |
| CYTOKINETICS INC                           | CYTOKINETICS INC                                   | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |    829782 | NS      | $45604818.72  | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Caris Life Sciences Inc Lockup Shs PP      | Caris Life Sciences, Inc. IPO                      | CUSIP: 000000000<br>LEI: 549300LX5LO78M5VPY43 | Long             | EC               | CORP              | US        |   1916953 | NS      | $57987828.25  | 0.53%             |  |  |  | Yes           |                  2 | On Loan: No      |
| DANAHER CORP                               | DANAHER CORP                                       | CUSIP: 235851102<br>LEI: S4BKK9OTCEWQ3YHPFM11 | Long             | EC               | CORP              | US        |   1392636 | NS      | $276104013.36 | 2.51%             |  |  |  | No            |                  1 | On Loan: No      |
| DELFI DIAGNOSTICS SR A CVT PFD STOCK PP    | DELFI DIAGNOSTICS SR A CVT PFD STOCK PP            | CUSIP: TC0LOSSE0<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   3426868 | NS      | $16605094.51  | 0.15%             |  |  |  | Yes           |                  3 | On Loan: No      |
| DELFI DIAGNOSTICS SR B CVT PFD STOCK PP    | DELFI DIAGNOSTICS SR B CVT PFD STOCK PP            | CUSIP: TC7ZV25B2<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1853138 | NS      | $8979491.37   | 0.08%             |  |  |  | Yes           |                  3 | On Loan: No      |
| DENALI THERAPEUTICS INC                    | DENALI THERAPEUTICS INC                            | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |   1555388 | NS      | $22584233.76  | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| DEXCOM INC                                 | DEXCOM INC                                         | CUSIP: 252131107<br>LEI: 549300YSK3QDSFR5EU59 | Long             | EC               | CORP              | US        |    311862 | NS      | $20985193.98  | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| DIANTHUS THERAPEUTICS INC                  | DIANTHUS THERAPEUTICS INC                          | CUSIP: 252828108<br>LEI: 549300Z3N6ODPCOFC890 | Long             | EC               | CORP              | US        |    163682 | NS      | $6440886.70   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| DISC MEDICINE INC                          | DISC MEDICINE INC                                  | CUSIP: 254604101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    364559 | NS      | $24090058.72  | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| DNA SCRIPT SERIES C CVT PFD STOCK PP       | DNA SCRIPT SERIES C CVT PFD STOCK PP               | CUSIP: TC3XW4UW2<br>LEI: 8945001SCRZOZAUEFH64 | Long             | EP               | CORP              | FR        |     25201 | NS      | $3513779.92   | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| EIKON THERA SERIES B CVT PFD STOCK PP      | EIKON THERA SERIES B CVT PFD STOCK PP              | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    762996 | NS      | $4459290.45   | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Eikon Therapeutic SER B-1 CVT PFD STK PP   | EIKON THERA SERIES B-1 CVT PFD STOCK PP            | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    774266 | NS      | $4525157.38   | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| EIKON THERAPEUTICS SER C CVT PFD STK PP    | EIKON THERAPEUTICS SER C CVT PFD STK PP            | CUSIP: TC0ZK0Q06<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    157292 | NS      | $919284.91    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Eikon Therapeutic SER C-1 CVT PFD STK PP   | EIKON THERAPEUTICS SER C-1 CVT PFD STK PP          | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    150661 | NS      | $880530.38    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| EIKON THERAPEUTIC SER D CVT PFD STK PP     | EIKON THERAPEUTICS SER D CVT PFD STK PP            | CUSIP: TC8MOJAD1<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    924929 | NS      | $5405699.44   | 0.05%             |  |  |  | Yes           |                  3 | On Loan: No      |
| EISAI CO LTD                               | EISAI CO LTD                                       | CUSIP: 000000000<br>LEI: 353800HDEE0ZYEX4QV91 | Long             | EC               | CORP              | JP        |    310200 | NS      | $10479426.12  | 0.10%             |  |  |  | No            |                  2 | On Loan: No      |
| ELEMENT BIOSCIENCES SER C CVT PFD STOCK PP | ELEMENT BIOSCIENCES SER C CVT PFD STOCK            | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    861217 | NS      | $5907948.62   | 0.05%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ELEMENT BIOSCIENCES SER D CVT PFD PP       | ELEMENT BIOSCIENCES SER D CVT PFD PP               | CUSIP: TC3OATBR3<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    281354 | NS      | $1561514.70   | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ELEMENT BIOSCIENCES SER D-1 CVT PFD PP     | ELEMENT BIOSCIENCES SER D-1 CVT PFD PP             | CUSIP: TC141T8S1<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    281354 | NS      | $1561514.70   | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ELEVANCE HEALTH INC                        | ELEVANCE HEALTH INC                                | CUSIP: 036752103<br>LEI: 8MYN82XMYQH89CTMTH67 | Long             | EC               | CORP              | US        |    335512 | NS      | $108410637.44 | 0.98%             |  |  |  | No            |                  1 | On Loan: No      |
| ELI LILLY & CO                             | ELI LILLY & CO                                     | CUSIP: 532457108<br>LEI: FRDRIPF3EKNDJ2CQJL29 | Long             | EC               | CORP              | US        |   1258512 | NS      | $960244656.00 | 8.72%             |  |  |  | No            |                  1 | On Loan: No      |
| ENCOMPASS HEALTH CORP                      | ENCOMPASS HEALTH CORP                              | CUSIP: 29261A100<br>LEI: 549300FVRPM9DRQZRG64 | Long             | EC               | CORP              | US        |    315558 | NS      | $40082177.16  | 0.36%             |  |  |  | No            |                  1 | On Loan: No      |
| ENDEAVOR BIO SERIES B CVT PFD STOCK PP     | END EAVOR BIO SERIES B CVT PFD STOCK PP            | CUSIP: TC0KH48I6<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1867734 | NS      | $12186217.26  | 0.11%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ENDEAVOR BIO SER C CVT PFD PP              | ENDEAVOR BIO SER C CVT PFD PP                      | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    489761 | NS      | $3195494.62   | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ENLIVEN THERAPEUTICS INC                   | ENLIVEN THERAPEUTICS INC                           | CUSIP: 29337E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    168137 | NS      | $3441764.39   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| ENTRADA THERAPEUTICS INC                   | ENTRADA THERAPEUTICS INC                           | CUSIP: 29384C108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    208383 | NS      | $1208621.40   | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| EXACT SCIENCES CORP                        | EXACT SCIENCES CORP                                | CUSIP: 30063P105<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |    755792 | NS      | $41349380.32  | 0.38%             |  |  |  | No            |                  1 | On Loan: No      |
| EXACT SCIENCES FDA MILESTONE PP            | EXACT SCIENCES FDA MILESTONE PP                    | CUSIP: 000000000<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |   1863136 | NS      | $0.00         | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| PARABILIS MED INC SER D CVT PFD STOCK PP   | FOG PHARMA SER D CVT PFD STOCK PP                  | CUSIP: TC2VY7UZ1<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    615203 | NS      | $4517189.55   | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| PARABILIS MED INC SER E CVT PFD STOCK PP   | FOG PHARMA SER E CVT PFD PP                        | CUSIP: TC0O5RRO6<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    623217 | NS      | $3881457.80   | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| PARABILIS MED INC SER C CVT PFD STOCK PP   | FOG PHARMACEUTICALS SERIES C CVT PFD STOCK PP      | CUSIP: TC4W1BVL4<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    431391 | NS      | $3661689.95   | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| FREENOME HOLDINGS SER B CVT PFD PP         | FREENOME HOLDINGS SER B CVT PFD PP                 | CUSIP: 000000000<br>LEI: 254900QDTSQ6S0QOCS43 | Long             | EP               | CORP              | US        |   1558570 | NS      | $7262936.20   | 0.07%             |  |  |  | Yes           |                  3 | On Loan: No      |
| FREENOME HOLDINGS SER C CVT PFD PP         | FREENOME HOLDINGS SER C CVT PFD PP                 | CUSIP: TC87S2BF1<br>LEI: 254900QDTSQ6S0QOCS43 | Long             | EP               | CORP              | US        |    928231 | NS      | $4492638.04   | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| FREENOME HOLDINGS SER D CVT PFD PP         | FREENOME HOLDINGS SER D CVT PFD PP                 | CUSIP: 000000000<br>LEI: 254900QDTSQ6S0QOCS43 | Long             | EP               | CORP              | US        |    526504 | NS      | $2600929.76   | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| FREENOME HOLDINGS SER F CVT PFD PP         | FREENOME HOLDINGS SER F CVT PFD PP                 | CUSIP: TC17ZDYA2<br>LEI: 254900QDTSQ6S0QOCS43 | Long             | EP               | CORP              | US        |    178707 | NS      | $877451.37    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Galvanize Therapeutics Ser C CVT PFD PP    | GALVANIZE THERAPEUTICS SER C CVT PFD PP            | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   7962282 | NS      | $4218496.63   | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| GENEDX HOLDINGS CORP WTS 7/26              | GENEDX HOLDINGS CORP                               | CUSIP: 81663L119<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    206747 | NS      | $22659.47     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| GENEDX HOLDINGS CORP                       | GENEDX HOLDINGS CORP                               | CUSIP: 81663L200<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    105900 | NS      | $11409666.00  | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| GENERATE BIO SER B CVT PFD STOCK PP        | GENERATE BIO SER B CVT PFD STOCK PP                | CUSIP: TC5CQ34B0<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1864632 | NS      | $22095889.20  | 0.20%             |  |  |  | Yes           |                  3 | On Loan: No      |
| GENERATE BIOMEDICINES INC SER C CVT PFD PP | GENERATE BIOMEDICINES INC SER C CVT PFD            | CUSIP: TC3JNBFQ7<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    372360 | NS      | $4412466.00   | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| GENERATION BIO CO                          | GENERATION BIO CO                                  | CUSIP: 37148K209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    135575 | NS      | $829719.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| GENESIS THERA SER A CVT PFD STOCK PP       | GENESIS THERA SER A CVT PFD STOCK PP               | CUSIP: TC08XH789<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    829412 | NS      | $4236304.73   | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| GENESIS THERA SER B CVT PFD STOCK PP       | GENESIS THERA SEV B CVT PFD STOCK PP               | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1987585 | NS      | $10151789.15  | 0.09%             |  |  |  | Yes           |                  3 | On Loan: No      |
| GILEAD SCIENCES INC                        | GILEAD SCIENCES INC                                | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |   2646403 | NS      | $293750733.00 | 2.67%             |  |  |  | No            |                  1 | On Loan: No      |
| GINKGO BIOWORKS HOLDINGS INC               | GINKGO BIOWORKS HOLDINGS INC                       | CUSIP: 37611X209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     27645 | NS      | $403064.10    | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| GUARDANT HEALTH INC                        | GUARDANT HEALTH INC                                | CUSIP: 40131M109<br>LEI: 254900M8C3E5VC8BR186 | Long             | EC               | CORP              | US        |   1150310 | NS      | $71871368.80  | 0.65%             |  |  |  | No            |                  1 | On Loan: No      |
| GYROSCOPE THERAPEUTICS MLSTNE PYMT 1 PP    | GYROSCOPE THERAPEUTICS MILESTONE PAYMENT 1 PP      | CUSIP: 000000000<br>LEI: 21380066POJ2YSHZAD73 | Long             | EC               | CORP              | US        |   5683928 | NS      | $0.00         | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| GYROSCOPE THERAPEUTICS MLSTNE PYMT 2 PP    | GYROSCOPE THERAPEUTICS MILESTONE PAYMENT 2 PP      | CUSIP: 000000000<br>LEI: 21380066POJ2YSHZAD73 | Long             | EC               | CORP              | US        |   3788007 | NS      | $0.00         | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| GYROSCOPE THERAPEUTICS MLSTNE PYMT 3 PP    | GYROSCOPE THERAPEUTICS MILESTONE PAYMENT 3 PP      | CUSIP: 000000000<br>LEI: 21380066POJ2YSHZAD73 | Long             | EC               | CORP              | US        |   3788007 | NS      | $0.00         | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| GALVANIZE THERA SER C-1 CVT PFD PP         | Galvanize Therapeutics Series C-1 CVT PFD          | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   7721685 | NS      | $4091025.93   | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| GALVANIZE THERA SER C-2 NV CVT PFD PP      | Galvanize Therapeutics Series C-2 CVT PFD          | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |  26100000 | NS      | $13828041.00  | 0.13%             |  |  |  | Yes           |                  3 | On Loan: No      |
| GINKGO BIOWORKS HLDS ERN OUT SHS 600 PP    | Ginkgo Bioworks Holdings Earn Out Shares $15.00 PP | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5317 | NS      | $0.00         | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| GINKGO BIOWORKS HLDS ERN OUT SHS 700 PP    | Ginkgo Bioworks Holdings Earn Out Shares $17.50 PP | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5317 | NS      | $0.00         | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| GINKGO BIOWORKS HLDS ERN OUT SH 800 PP     | Ginkgo Bioworks Holdings Earn Out Shares $20.00 PP | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5317 | NS      | $0.00         | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| HCA HEALTHCARE INC                         | HCA HEALTHCARE INC                                 | CUSIP: 40412C101<br>LEI: 529900PH4ZGUH2MNEU89 | Long             | EC               | CORP              | US        |    225584 | NS      | $96143900.80  | 0.87%             |  |  |  | No            |                  1 | On Loan: No      |
| HEARTFLOW INC                              | HEARTFLOW INC                                      | CUSIP: 42238D107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    479354 | NS      | $16135055.64  | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| HIMS & HERS HEALTH INC                     | HIMS & HERS HEALTH INC                             | CUSIP: 433000106<br>LEI: 254900V041EIVTSB6D58 | Long             | EC               | CORP              | US        |    131501 | NS      | $7458736.72   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| HONOR TECHNOLOGY SER D CVT PFD PP          | HONOR TECHNOLOGY SER D CVT PFD PP                  | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   3130941 | NS      | $4195460.94   | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| HONOR TECHNOLOGY SER E CVT PFD STOCK PP    | HONOR TECHNOLOGY SER E CVT PFD STOCK PP            | CUSIP: TC2V4FT13<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   2095807 | NS      | $2808381.38   | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ICON PLC                                   | ICON PLC                                           | CUSIP: 000000000<br>LEI: 6354008SRQGEMC4XFI67 | Long             | EC               | CORP              | IE        |     79581 | NS      | $13926675.00  | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| IDEAYA BIOSCIENCES INC                     | IDEAYA BIOSCIENCES INC                             | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |    163057 | NS      | $4436780.97   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| IDEXX LABORATORIES INC                     | IDEXX LABORATORIES INC                             | CUSIP: 45168D104<br>LEI: OGMTXK0LUU1HKV2P0J84 | Long             | EC               | CORP              | US        |    107602 | NS      | $68745841.78  | 0.62%             |  |  |  | No            |                  1 | On Loan: No      |
| IMMATICS NV                                | IMMATICS NV                                        | CUSIP: N44445109<br>LEI: 984500DC691EZ96AF394 | Long             | EC               | CORP              | NL        |    504959 | NS      | $4302250.68   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| IMMUNEERING CORP - CLASS A                 | IMMUNEERING CORP                                   | CUSIP: 45254E107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    877266 | NS      | $6140862.00   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| IMMUNOCORE HOLDINGS CB 2.50% 2/30          | IMMUNOCORE HOLDINGS PLC                            | CUSIP: 45258DAB1<br>LEI: 213800IUE3DFS84BVN18 | Long             | DBT              | CORP              | GB        |  15469000 | PA      | $14021178.95  | 0.13%             | 2030-02-01      | Fixed         | 2.50%                 | No            |                  2 | On Loan: No      |
| IMMUNOCORE HOLDINGS PLC-ADR                | IMMUNOCORE HOLDINGS PLC                            | CUSIP: 45258D105<br>LEI: 213800IUE3DFS84BVN18 | Long             | EC               | CORP              | GB        |    795098 | NS      | $28885910.34  | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| IMMUNOME INC                               | IMMUNOME INC                                       | CUSIP: 45257U108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2840465 | NS      | $33261845.15  | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| INCYTE CORP                                | INCYTE CORP                                        | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |    428475 | NS      | $36338964.75  | 0.33%             |  |  |  | No            |                  1 | On Loan: No      |
| INSITRO SER B CVT PFD PP                   | INSITRO SER B CVT PFD PP                           | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    883580 | NS      | $16161650.14  | 0.15%             |  |  |  | Yes           |                  3 | On Loan: No      |
| INSITRO SER C CVT PFD PP                   | INSITRO SER C CVT PFD PP                           | CUSIP: TC3HHHWL7<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    588382 | NS      | $10762154.00  | 0.10%             |  |  |  | Yes           |                  3 | On Loan: No      |
| INSMED INC                                 | INSMED INC                                         | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |   2322023 | NS      | $334394532.23 | 3.04%             |  |  |  | No            |                  1 | On Loan: No      |
| INTUITIVE SURGICAL INC                     | INTUITIVE SURGICAL INC                             | CUSIP: 46120E602<br>LEI: 54930052SRG011710797 | Long             | EC               | CORP              | US        |   1170929 | NS      | $523674576.67 | 4.75%             |  |  |  | No            |                  1 | On Loan: No      |
| IONIS PHARMACEUTICALS INC                  | IONIS PHARMACEUTICALS INC                          | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |    896990 | NS      | $58681085.80  | 0.53%             |  |  |  | No            |                  1 | On Loan: No      |
| IOVANCE BIOTHERAPEUTICS INC                | IOVANCE BIOTHERAPEUTICS INC                        | CUSIP: 462260100<br>LEI: 2549002L8WT2ACU5Q878 | Long             | EC               | CORP              | US        |    699836 | NS      | $1518644.12   | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| IQVIA HOLDINGS INC                         | IQVIA HOLDINGS INC                                 | CUSIP: 46266C105<br>LEI: 549300W3R20NM4KQPH86 | Long             | EC               | CORP              | US        |    162177 | NS      | $30803899.38  | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| JANUX THERAPEUTICS INC                     | JANUX THERAPEUTICS INC                             | CUSIP: 47103J105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    353221 | NS      | $8632721.24   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| KARDIUM INC SER D-5 CVT PFD STOCK PP       | KARDIUM INC SER D-5 CVT PFD STOCK PP               | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   8849057 | NS      | $7249147.49   | 0.07%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Kardium Inc Series D-8 CVT PFD Stock PP    | KARDIUM INC SERIES D-8 CVT PFD STOCK PP            | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | CA        |   6786958 | NS      | $4392790.70   | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Kardium Inc Ser D-6 CVT Pfd Stock PP       | KARDIUM SERIES D6 CVT PFD STOCK PP                 | CUSIP: TC0GUUWU8<br>LEI: N/A                  | Long             | EP               | CORP              | US        |  12320393 | NS      | $10193893.17  | 0.09%             |  |  |  | Yes           |                  3 | On Loan: No      |
| KARTOS THERAPEUTICS SR C CVT PFD STK PP    | KARTOS THERAPEUTICS SR C CVT PFD STK PP            | CUSIP: TC1HQTAC7<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1873841 | NS      | $10592823.17  | 0.10%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Kartos Therapeutics SR D CVT PFD STK PP    | KARTOS THERAPEUTICS SR D CVT PFD STK PP            | CUSIP: TC82Z0AE2<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    513724 | NS      | $2904081.77   | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| KESTRA MEDICAL TECHNOLOGIES                | KESTRA MEDICAL TECHNOLOGIES LTD                    | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    589903 | NS      | $14016095.28  | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| KODIAK SCIENCES INC                        | KODIAK SCIENCES INC                                | CUSIP: 50015M109<br>LEI: 254900IXI5NI8C9OQE24 | Long             | EC               | CORP              | US        |    365454 | NS      | $5982481.98   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| KRYSTAL BIOTECH INC                        | KRYSTAL BIOTECH INC                                | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |    275394 | NS      | $48615302.82  | 0.44%             |  |  |  | No            |                  1 | On Loan: No      |
| KYMERA THERAPEUTICS INC                    | KYMERA THERAPEUTICS INC                            | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1181134 | NS      | $66852184.40  | 0.61%             |  |  |  | No            |                  1 | On Loan: No      |
| KYVERNA THERAPEUTICS INC                   | KYVERNA THERAPEUTICS INC                           | CUSIP: 501976104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1149489 | NS      | $6896934.00   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Kardium Inc Series D-7 CVT PFD Stock PP    | Kardium, Inc. Series D-7 CVT Pfd Stock             | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |  12050573 | NS      | $7799612.87   | 0.07%             |  |  |  | Yes           |                  3 | On Loan: No      |
| SAIL BIOMEDICINES SER B CVT PFD STOCK PP   | LARONDE SERIES B CVT PFD STOCK PP                  | CUSIP: TC14DLDG5<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1169887 | NS      | $1684637.28   | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| LB PHARMACEUTICALS INC                     | LB PHARMACEUTICALS INC                             | CUSIP: 50180M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    224479 | NS      | $3544523.41   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| LENZ THERAPEUTICS INC                      | LENZ THERAPEUTICS INC                              | CUSIP: 52635N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    185948 | NS      | $8661457.84   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| LUMICKS TECH SER D CVT PFD STOCK PP        | LUMICKS TECH SER D CVT PFD STOCK PP                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |      4954 | NS      | $2670106.92   | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| MADRIGAL PHARMACEUTICALS INC               | MADRIGAL PHARMACEUTICALS INC                       | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |     80311 | NS      | $36835443.26  | 0.33%             |  |  |  | No            |                  1 | On Loan: No      |
| MBX BIOSCIENCES INC                        | MBX BIOSCIENCES INC                                | CUSIP: 55287L101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    705318 | NS      | $12343065.00  | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| MCKESSON CORP                              | MCKESSON CORP                                      | CUSIP: 58155Q103<br>LEI: 549300WZWOM80UCFSF54 | Long             | EC               | CORP              | US        |     31585 | NS      | $24400675.90  | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| MEDIWOUND LTD                              | MEDIWOUND LTD                                      | CUSIP: 000000000<br>LEI: 549300LJKCS74GRYKF90 | Long             | EC               | CORP              | IL        |    288408 | NS      | $5197112.16   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| MERUS NV                                   | MERUS NV                                           | CUSIP: 000000000<br>LEI: 549300W8GPUWU8QNU293 | Long             | EC               | CORP              | NL        |    378882 | NS      | $35671740.30  | 0.32%             |  |  |  | No            |                  1 | On Loan: No      |
| MIRUM PHARMACEUTICALS INC                  | MIRUM PHARMACEUTICALS INC                          | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |     90644 | NS      | $6645111.64   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| MOLINA HEALTHCARE INC                      | MOLINA HEALTHCARE INC                              | CUSIP: 60855R100<br>LEI: 549300NQQCEQ46YHZ591 | Long             | EC               | CORP              | US        |    115312 | NS      | $22066104.32  | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| MONTE ROSA THERAPEUTICS INC                | MONTE ROSA THERAPEUTICS INC                        | CUSIP: 61225M102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1000544 | NS      | $7414031.04   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| MOONLAKE IMMUNOTHERAPEUTICS                | MOONLAKE IMMUNOTHERAPEUTICS                        | CUSIP: 61559X104<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |    644713 | NS      | $4622592.21   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| MANUS BIO INC SERIES ONE-6 CVT PFD PP      | Manus Bio, Inc Series One-6                        | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1223104 | NS      | $3669312.00   | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| NATERA INC                                 | NATERA INC                                         | CUSIP: 632307104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    666552 | NS      | $107294875.44 | 0.97%             |  |  |  | No            |                  1 | On Loan: No      |
| NATIONAL RESILIENCE SR B CVT PFD STK PP    | NATIONAL RESILIENCE SER B CVT PFD STOCK            | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1204832 | NS      | $19361650.24  | 0.18%             |  |  |  | Yes           |                  3 | On Loan: No      |
| NATIONAL RESILIENCE SR C CVT PFD STK PP    | NATIONAL RESILIENCE SER C CVT PFD STOCK            | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    426855 | NS      | $6859559.85   | 0.06%             |  |  |  | Yes           |                  3 | On Loan: No      |
| NEUROCRINE BIOSCIENCES INC                 | NEUROCRINE BIOSCIENCES INC                         | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |    483173 | NS      | $67827825.74  | 0.62%             |  |  |  | No            |                  1 | On Loan: No      |
| NEWAMSTERDAM PHARMA CO NV                  | NEWAMSTERDAM PHARMA CO NV                          | CUSIP: 000000000<br>LEI: 984500B6549TF6E14D36 | Long             | EC               | CORP              | NL        |    104795 | NS      | $2980369.80   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| NUTCRACKER THERA SER C CVT PFD STOCK PP    | NUTCRACKER THERA SER C CVT PFD STOCK PP            | CUSIP: TC3WVBUQ2<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1027785 | NS      | $1469732.55   | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| NUVALENT INC-A                             | NUVALENT INC                                       | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    436992 | NS      | $37791068.16  | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| OBSIDIAN THERAPEUTIC SR C CVT PFD STK PP   | OBSIDIAN THERAPEUTICS SR C CVT PFD STK PP          | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   4647794 | NS      | $8821048.23   | 0.08%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Odyssey Therapeutics SER D CVT Pfd Stk PP  | ODYSSEY THERAPEUTICS SER D CVT PFD STK PP          | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    444487 | NS      | $668939.60    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ODYSSEY THERAPEUTICS SR B CVT PFD STK PP   | ODYSSEY THERAPEUTICS SR B CVT PFD STK PP           | CUSIP: TC4CBMMO7<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1115915 | NS      | $1763145.70   | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ODYSSEY THERAPEUTICS SR C CVT PFD STK PP   | ODYSSEY THERAPEUTICS SR C CVT PFD STK PP           | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    105905 | NS      | $159383.85    | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Odyssey Therapeutics Warrants 6/32 WRT PP  | ODYSSEY THERAPEUTICS WARRANTS 6/32 WRT PP          | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    133346 | NS      | $0.00         | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ORCHESTRA BIOMED HOLDINGS INC              | ORCHESTRA BIOMED HOLDINGS INC                      | CUSIP: 68572M106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    281462 | NS      | $698025.76    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| ORIC PHARMACEUTICALS INC                   | ORIC PHARMACEUTICALS INC                           | CUSIP: 68622P109<br>LEI: 54930033FJRNEYBW0L25 | Long             | EC               | CORP              | US        |    888638 | NS      | $10663656.00  | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| ORUKA THERAPEUTICS INC                     | ORUKA THERAPEUTICS INC                             | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |    245709 | NS      | $4724984.07   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Oruka Therapeutics, Inc. PIPE 09/25 PP     | ORUKA THERAPEUTICS INC PIPE 9.25 PP                | CUSIP: 000000000<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |    204709 | NS      | $3739726.37   | 0.03%             |  |  |  | Yes           |                  2 | On Loan: No      |
| PAX LABS CLASS A COMMON PP                 | PAX LABS CLASS A COMMON PP                         | CUSIP: 000000000<br>LEI: 549300FKJA0AEKUHVG68 | Long             | EC               | CORP              | US        |   8397988 | NS      | $2603376.28   | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| PENUMBRA INC                               | PENUMBRA INC                                       | CUSIP: 70975L107<br>LEI: 549300RGE06P3ECANU72 | Long             | EC               | CORP              | US        |    587439 | NS      | $148810047.48 | 1.35%             |  |  |  | No            |                  1 | On Loan: No      |
| PHARVARIS NV                               | PHARVARIS NV                                       | CUSIP: 000000000<br>LEI: 9845003BE146D3B75D32 | Long             | EC               | CORP              | NL        |    635208 | NS      | $15848439.60  | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| PRAXIS PRECISION MEDICINES I               | PRAXIS PRECISION MEDICINES INC                     | CUSIP: 74006W207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    241677 | NS      | $12808881.00  | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| PRELUDE THERAPEUTICS INC                   | PRELUDE THERAPEUTICS INC                           | CUSIP: 74065P101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    627619 | NS      | $903771.36    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| PROCEPT BIOROBOTICS CORP                   | PROCEPT BIOROBOTICS CORP                           | CUSIP: 74276L105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    502360 | NS      | $17929228.40  | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| PROFOUNDBIO ESCROW FUND PAYMENT PP         | PROFOUNBIO ESCROW FUND PAYMENT                     | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    704486 | NS      | $669261.67    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| PROFOUNDBIO EXPENSE FUND PAYMENT PP        | PROFOUNDBIO EXPENSE FUND PYMT                      | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |      2348 | NS      | $469.66       | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| PROGNOMIQ INC CL A Common  PP              | PROGNOMIQ INC PP                                   | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    606647 | NS      | $90997.05     | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| PROTAGONIST THERAPEUTICS INC               | PROTAGONIST THERAPEUTICS INC                       | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    913443 | NS      | $60680018.49  | 0.55%             |  |  |  | No            |                  1 | On Loan: No      |
| QUEST DIAGNOSTICS INC                      | QUEST DIAGNOSTICS INC                              | CUSIP: 74834L100<br>LEI: 8MCWUBXQ0WE04KMXBX50 | Long             | EC               | CORP              | US        |    409408 | NS      | $78024976.64  | 0.71%             |  |  |  | No            |                  1 | On Loan: No      |
| RADNET INC                                 | RADNET INC                                         | CUSIP: 750491102<br>LEI: 529900RECG94V2IZJ970 | Long             | EC               | CORP              | US        |    143269 | NS      | $10918530.49  | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| RAPPORT THERAPEUTICS INC                   | RAPPORT THERAPEUTICS INC                           | CUSIP: 75383L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    835510 | NS      | $24814647.00  | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Reflexion Med CVT Note issued 082725 PP    | REFLEXION MED CVT NOTE ISSUED 082725 PP            | CUSIP: 000000000<br>LEI: N/A                  | Long             | DBT              | CORP              | US        |    239698 | PA      | $373928.86    | 0.00%             | 2026-07-11      | Fixed         | 15.00%                | Yes           |                  3 | On Loan: No      |
| Reflexion Med CVT Note issued 081325 PP    | REFLEXION MED CVT PROM NOTE 081325 PP              | CUSIP: 000000000<br>LEI: N/A                  | Long             | DBT              | CORP              | US        |    239698 | PA      | $376325.84    | 0.00%             | 2026-07-11      | Fixed         | 15.00%                | Yes           |                  3 | On Loan: No      |
| Reflexion Med CVT Note issued 072525 PP    | REFLEXION MEDICAL CVT PROM NOTE PP                 | CUSIP: 000000000<br>LEI: N/A                  | Long             | DBT              | CORP              | US        |    239698 | PA      | $378722.82    | 0.00%             | 2026-08-11      | None          | 0.00%                 | Yes           |                  3 | On Loan: No      |
| REFLEXION MEDICAL INC CVT PFD SR D-X PP    | REFLEXION MEDICAL INC CVT                          | CUSIP: TC70GKL85<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1123437 | NS      | $516781.02    | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| REFLEXION MEDICAL INC CVT PFD SR C-X PP    | REFLEXION MEDICAL INC CVT PFD SR C PP              | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   2507885 | NS      | $1028232.85   | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| REFLEXION MEDICAL SER F CVT PFD STOCK PP   | REFLEXION MEDICAL INC PP                           | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1794104 | NS      | $645877.44    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| REFLEXION MEDICAL INC CVT PFD SR E-X PP    | REFLEXION MEDICAL INC SR E CVT PFD PP              | CUSIP: TC9L8ZXJ6<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1857286 | NS      | $1058653.02   | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| REGENERON PHARMACEUTICALS                  | REGENERON PHARMACEUTICALS INC                      | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |    295941 | NS      | $166398746.07 | 1.51%             |  |  |  | No            |                  1 | On Loan: No      |
| RELAY THERAPEUTICS INC                     | RELAY THERAPEUTICS INC                             | CUSIP: 75943R102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    691735 | NS      | $3610856.70   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| REPLIGEN CORP                              | REPLIGEN CORP                                      | CUSIP: 759916109<br>LEI: 54930006QJ0T5AUO1E71 | Long             | EC               | CORP              | US        |     78320 | NS      | $10469034.40  | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| REPLIMUNE GROUP INC                        | REPLIMUNE GROUP INC                                | CUSIP: 76029N106<br>LEI: 549300AY704NEIRC4K64 | Long             | EC               | CORP              | US        |   1659826 | NS      | $6954670.94   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| REVOLUTION MEDICINES INC                   | REVOLUTION MEDICINES INC                           | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |   1528050 | NS      | $71359935.00  | 0.65%             |  |  |  | No            |                  1 | On Loan: No      |
| REVOLUTION MEDICINES INC WTS 12/26         | REVOLUTION MEDICINES INC                           | CUSIP: 76155X118<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |    198505 | NS      | $59551.50     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| REVVITY INC                                | REVVITY INC                                        | CUSIP: 714046109<br>LEI: 549300IKL1SDPFI7N655 | Long             | EC               | CORP              | US        |    349172 | NS      | $30604925.80  | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| RHYTHM PHARMACEUTICALS INC                 | RHYTHM PHARMACEUTICALS INC                         | CUSIP: 76243J105<br>LEI: 529900JPNWXQ8DPLA551 | Long             | EC               | CORP              | US        |    354272 | NS      | $35777929.28  | 0.32%             |  |  |  | No            |                  1 | On Loan: No      |
| RING THERAPEUTICS INC PP                   | RING THERAPEUTICS INC PP                           | CUSIP: TC4CR9CB8<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    291704 | NS      | $1341838.40   | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ROCKET PHARMACEUTICALS INC                 | ROCKET PHARMACEUTICALS INC                         | CUSIP: 77313F106<br>LEI: 549300R7VV82YUIN4Y93 | Long             | EC               | CORP              | US        |    653206 | NS      | $2129451.56   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| ROIVANT SCIENCES LTD                       | ROIVANT SCIENCES LTD                               | CUSIP: 000000000<br>LEI: 549300DL466NY5J6U724 | Long             | EC               | CORP              | BM        |   1934568 | NS      | $29270013.84  | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| ROYALTY PHARMA PLC- CL A                   | ROYALTY PHARMA PLC                                 | CUSIP: 000000000<br>LEI: 549300FGFN7VOK8BZR03 | Long             | EC               | CORP              | GB        |    575442 | NS      | $20301593.76  | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| SALIOGEN THERA SERIES B CVT PFD STOCK PP   | SALIOGEN THERA SERIES B CVT PFD STOCK PP           | CUSIP: TC46G6E19<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    104129 | NS      | $0.00         | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| SALUDA MEDICAL CVT PROM NOTE PP            | SALUDA MEDICAL CVT PROM NOTE PP                    | CUSIP: 000000000<br>LEI: N/A                  | Long             | DBT              | CORP              | US        |   2201800 | PA      | $2201800.00   | 0.02%             | 2026-12-31      | None          | 0.00%                 | Yes           |                  3 | On Loan: No      |
| SALUDA MEDICAL INC SERIES E CVT PFD PP     | SALUDA MEDICAL INC SERIES E CVT PFD PP             | CUSIP: TC68T3TI3<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    266476 | NS      | $1161835.36   | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| SALUDA MEDICAL SER E-1 CVT PFD PP          | SALUDA MEDICAL INC SERIES E-1 CVT PFD PP           | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    272710 | NS      | $1189015.60   | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| SALUDA MEDICAL SERIES D CVT PFD STOCK PP   | SALUDA MEDICAL SERIES D CVT PFD STOCK PP           | CUSIP: TC460A8T3<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    690617 | NS      | $3314961.60   | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| SALUDA MEDICAL WTS 1/27 PP                 | SALUDA MEDICAL WTS 1/23 PP                         | CUSIP: TC4G9B837<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    103592 | NS      | $0.00         | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| SANOFI ADR                                 | SANOFI SA                                          | CUSIP: 80105N105<br>LEI: 549300E9PC51EN656011 | Long             | EC               | CORP              | FR        |   1253328 | NS      | $59157081.60  | 0.54%             |  |  |  | No            |                  1 | On Loan: No      |
| SARTORIUS AG-VORZUG PREF                   | SARTORIUS AG                                       | CUSIP: 000000000<br>LEI: 529900EQV2DY4FOAMU38 | Long             | EP               | CORP              | DE        |     84543 | NS      | $19764178.75  | 0.18%             |  |  |  | No            |                  2 | On Loan: No      |
| SCHOLAR ROCK HOLDING CORP                  | SCHOLAR ROCK HOLDING CORP                          | CUSIP: 80706P103<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |   1896778 | NS      | $70636012.72  | 0.64%             |  |  |  | No            |                  1 | On Loan: No      |
| SCRIBE THERA SER B CVT PFD STOCK PP        | SCRIBE THERA SER B CVT PFD STOCK PP                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1027755 | NS      | $6219253.83   | 0.06%             |  |  |  | Yes           |                  3 | On Loan: No      |
| SEAPORT THERAPEUTICS SER B CVT PFD PP      | SEAPORT THERAPEUTICS SER B CVT PFD PP              | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   2322209 | NS      | $11030492.75  | 0.10%             |  |  |  | Yes           |                  3 | On Loan: No      |
| SENSORION SA                               | SENSORION SA                                       | CUSIP: 000000000<br>LEI: 969500P0W8XJ9CGZDP97 | Long             | EC               | CORP              | FR        |  10026597 | NS      | $4037839.65   | 0.04%             |  |  |  | No            |                  2 | On Loan: No      |
| SIONNA THERAPEUTICS INC                    | SIONNA THERAPEUTICS INC                            | CUSIP: 829401108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    513088 | NS      | $15089918.08  | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| SOLENO THERAPEUTICS INC                    | SOLENO THERAPEUTICS INC                            | CUSIP: 834203309<br>LEI: 5493003LCY77N7FXK844 | Long             | EC               | CORP              | US        |    688986 | NS      | $46575453.60  | 0.42%             |  |  |  | No            |                  1 | On Loan: No      |
| SOMALOGIC INC WTS 8/26                     | SOMALOGIC INC                                      | CUSIP: 83444K113<br>LEI: 549300D3W3Q8CN30YO25 | Long             | EC               | CORP              | US        |     90179 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  2 | On Loan: No      |
| SONOVA HOLDING AG-REG                      | SONOVA HOLDING AG                                  | CUSIP: 000000000<br>LEI: 5299004A0QNX7FBNHS61 | Long             | EC               | CORP              | CH        |    154021 | NS      | $42248941.47  | 0.38%             |  |  |  | No            |                  2 | On Loan: No      |
| Spyre Therapeutics Inc                     | SPYRE THERAPEUTICS INC                             | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |    423266 | NS      | $7093938.16   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| STRUCTURE THERAPEUTICS INC ADR             | STRUCTURE THERAPEUTICS INC                         | CUSIP: 86366E106<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |    213057 | NS      | $5965596.00   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| STRYKER CORP                               | STRYKER CORP                                       | CUSIP: 863667101<br>LEI: 5493002F0SC4JTBU5137 | Long             | EC               | CORP              | US        |   1365303 | NS      | $504711560.01 | 4.58%             |  |  |  | No            |                  1 | On Loan: No      |
| SUMMIT THERAPEUTICS INC                    | SUMMIT THERAPEUTICS INC                            | CUSIP: 86627T108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   3273721 | NS      | $67635075.86  | 0.61%             |  |  |  | No            |                  1 | On Loan: No      |
| T. Rowe Price Government Reserve Fund      | T. Rowe Price Government Reserve Fund              | CUSIP: 76105Y109<br>LEI: 5493002Y0IYARJVQ5N24 | Long             | STIV             | RF                | US        |  44234114 | NS      | $44234113.99  | 0.40%             |  |  |  | No            |                  1 | On Loan: No      |
| TARSUS PHARMACEUTICALS INC                 | TARSUS PHARMACEUTICALS INC                         | CUSIP: 87650L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    322485 | NS      | $19165283.55  | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| TEMPUS AI INC                              | TEMPUS AI INC                                      | CUSIP: 88023B103<br>LEI: 2549009LA0KWRAGQBX50 | Long             | EC               | CORP              | US        |    188745 | NS      | $15233608.95  | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| TENAX THERAPEUTICS PRE FUND WTS PIPE PP    | TENAX THERAPEUTICS PRE FUNDED WTS PP               | CUSIP: 000000000<br>LEI: 549300J03O6B1IJ2B606 | Long             | EC               | CORP              | US        |   2095785 | NS      | $15136943.39  | 0.14%             |  |  |  | Yes           |                  2 | On Loan: No      |
| TENET HEALTHCARE CORP                      | TENET HEALTHCARE CORP                              | CUSIP: 88033G407<br>LEI: 0W9AIBT6U6ADJ2I8HK17 | Long             | EC               | CORP              | US        |    589716 | NS      | $119735936.64 | 1.09%             |  |  |  | No            |                  1 | On Loan: No      |
| TESSERA THERAPEUTICS SER D CVT PFD PP      | TESSERA THERAPEUTICS SER D CVT PFD PP              | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    381989 | NS      | $1978703.02   | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| THERMO FISHER SCIENTIFIC INC               | THERMO FISHER SCIENTIFIC INC                       | CUSIP: 883556102<br>LEI: HCHV7422L5HDJZCRFL38 | Long             | EC               | CORP              | US        |    857337 | NS      | $415825591.74 | 3.78%             |  |  |  | No            |                  1 | On Loan: No      |
| THIRD ARC BIO SER A CVT PFD PP             | THIRD ARC BIO SER A CVT PFD PP                     | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   4194043 | NS      | $8825105.28   | 0.08%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Treeline Bio Common WTS 8/35 PP            | TREELINE BIO COMMON WTS 8.35 PP                    | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     44917 | NS      | $327310.18    | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| TREELINE BIO SER A CVT PFD STOCK PP        | TREELINE BIO SER A CVT PFD STOCK PP                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   2370150 | NS      | $17271283.05  | 0.16%             |  |  |  | Yes           |                  3 | On Loan: No      |
| TREELINE BIO SER A-1 CVT PFD STOCK PP      | TREELINE BIO SER A-1 CVT PFD STOCK PP              | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   2744291 | NS      | $19997648.52  | 0.18%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Treeline Bio SER A-2 NV CVT PFD PP         | TREELINE BIO SER A-2 NV CVT PFD PP                 | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    299448 | NS      | $2182077.58   | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| TENAX THERAPEUTICS NEW WTS 8/29 PIPE PP    | Tenax Therapeutics, Inc                            | CUSIP: 000000000<br>LEI: 549300J03O6B1IJ2B606 | Long             | EC               | CORP              | US        |   1103045 | NS      | $1248371.18   | 0.01%             |  |  |  | Yes           |                  2 | On Loan: No      |
| TESSERA THERAPEUTICS SER C' CVT PFD PP     | Tessera Therapeutics, Inc. Series C                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    674174 | NS      | $3492221.32   | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ULTRAGENYX PHARMACEUTICAL INC              | ULTRAGENYX PHARMACEUTICAL INC                      | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |    592307 | NS      | $17816594.56  | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| UNIQURE NV                                 | UNIQURE NV                                         | CUSIP: 000000000<br>LEI: 724500RPCTZLFYJZ3S98 | Long             | EC               | CORP              | NL        |    581982 | NS      | $33970289.34  | 0.31%             |  |  |  | No            |                  1 | On Loan: No      |
| UNITED THERAPEUTICS CORP                   | UNITED THERAPEUTICS CORP                           | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |    201852 | NS      | $84618376.92  | 0.77%             |  |  |  | No            |                  1 | On Loan: No      |
| UNITEDHEALTH GROUP INC                     | UNITEDHEALTH GROUP INC                             | CUSIP: 91324P102<br>LEI: 549300GHBMY8T5GXDE41 | Long             | EC               | CORP              | US        |   1306949 | NS      | $451289489.70 | 4.10%             |  |  |  | No            |                  1 | On Loan: No      |
| UROGEN PHARMA LTD                          | UROGEN PHARMA LTD                                  | CUSIP: 000000000<br>LEI: 549300C0YCX7CG2G5D50 | Long             | EC               | CORP              | IL        |    262756 | NS      | $5241982.20   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| VAXCYTE INC                                | VAXCYTE INC                                        | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |    880978 | NS      | $31732827.56  | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| VEEVA SYSTEMS INC CL A                     | VEEVA SYSTEMS INC                                  | CUSIP: 922475108<br>LEI: 549300YZEXPDB92M2F02 | Long             | EC               | CORP              | US        |    192708 | NS      | $57409640.28  | 0.52%             |  |  |  | No            |                  1 | On Loan: No      |
| VERA THERAPEUTICS INC                      | VERA THERAPEUTICS INC                              | CUSIP: 92337R101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1277521 | NS      | $37124760.26  | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| VERASTEM INC                               | VERASTEM INC                                       | CUSIP: 92337C203<br>LEI: 549300IY0EFBIU8NQC81 | Long             | EC               | CORP              | US        |    434632 | NS      | $3837800.56   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| VERILY LIFE SCIENCES LLC SER B UNITS PP    | VERILY LIFE SCIENCES LLC SER B UNITS PP            | CUSIP: 000000000<br>LEI: 5493003ZYK1Z7M670M44 | Long             | EC               | CORP              | US        |    113564 | NS      | $3747612.00   | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| VERTEX PHARMACEUTICALS INC                 | VERTEX PHARMACEUTICALS INC                         | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |    659165 | NS      | $258155380.60 | 2.34%             |  |  |  | No            |                  1 | On Loan: No      |
| VIRIDIAN THERAPEUTICS INC                  | VIRIDIAN THERAPEUTICS INC                          | CUSIP: 92790C104<br>LEI: 549300C775BNYF550E70 | Long             | EC               | CORP              | US        |    478324 | NS      | $10322231.92  | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| VOYAGER THERAPEUTICS INC                   | VOYAGER THERAPEUTICS INC                           | CUSIP: 92915B106<br>LEI: 54930082S4XVR0ZWCC74 | Long             | EC               | CORP              | US        |    332596 | NS      | $1553223.32   | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| WATERS CORP                                | WATERS CORP                                        | CUSIP: 941848103<br>LEI: 5T547R1474YC9HOD8Q74 | Long             | EC               | CORP              | US        |     18779 | NS      | $5630131.99   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| WAVE LIFE SCIENCES LTD                     | WAVE LIFE SCIENCES LTD                             | CUSIP: 000000000<br>LEI: 54930070006GPKFYZ813 | Long             | EC               | CORP              | SG        |    855344 | NS      | $6261118.08   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| XENCOR INC                                 | XENCOR INC                                         | CUSIP: 98401F105<br>LEI: 549300V5IF65437JKG30 | Long             | EC               | CORP              | US        |    532245 | NS      | $6243233.85   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| ZAI LAB LTD ADR                            | ZAI LAB LTD                                        | CUSIP: 98887Q104<br>LEI: 549300P2UYQ9U5LY1T58 | Long             | EC               | CORP              | KY        |    737906 | NS      | $25007634.34  | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2025-11-05

**Name of Applicant:** T. ROWE PRICE HEALTH SCIENCES FUND, INC.

**Signature:** /s/ Alan Dupski

**Name of Signer:** Alan Dupski

**Title:** Treasurer & Vice President