# EDGAR Filing Document

**Accession Number:** 0001808158
**File Stem:** 0000921895-25-003182
**Filing Date:** 2025-11
**Character Count:** 46826
**Document Hash:** c8ea5c7e55a472c975ce48a3fce53fa7
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000921895-25-003182.hdr.sgml**: 20251124

**ACCESSION NUMBER**: 0000921895-25-003182

**CONFORMED SUBMISSION TYPE**: SCHEDULE 13D/A

**PUBLIC DOCUMENT COUNT**: 2

**FILED AS OF DATE**: 20251124

**DATE AS OF CHANGE**: 20251124

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Repare Therapeutics Inc.
- **CENTRAL INDEX KEY:** 0001808158
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** Z4
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SCHEDULE 13D/A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-91542
- **FILM NUMBER:** 251514080

**BUSINESS ADDRESS:**
- **STREET 1:** 7171 FREDERICK BANTING
- **STREET 2:** SUITE 270, BUILDING 2
- **CITY:** SAINT-LAURENT
- **STATE:** A8
- **ZIP:** H4S 1Z9
- **BUSINESS PHONE:** (857) 412-7018

**MAIL ADDRESS:**
- **STREET 1:** 7171 FREDERICK BANTING
- **STREET 2:** SUITE 270, BUILDING 2
- **CITY:** SAINT-LAURENT
- **STATE:** A8
- **ZIP:** H4S 1Z9
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** BIOTECHNOLOGY VALUE FUND L P
- **CENTRAL INDEX KEY:** 0000918923
- **STANDARD INDUSTRIAL CLASSIFICATION:** INVESTMENT ADVICE [6282]
- **ORGANIZATION NAME:** 02 Finance
- **EIN:** 363924731
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SCHEDULE 13D/A

**BUSINESS ADDRESS:**
- **STREET 1:** 44 MONTGOMERY STREET
- **STREET 2:** 40TH FL
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94104
- **BUSINESS PHONE:** 3125066500

**MAIL ADDRESS:**
- **STREET 1:** 44 MONTGOMERY STREET
- **STREET 2:** 40TH FL
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94104

## Exhibit 99.1

Exhibit 99.1

**VOTING AND SUPPORT AGREEMENT**

November [●], 2025

REPARE THERAPEUTICS INC.

7171 Frederick-Banting, Suite 270

Saint-Laurent, Québec H4S 1Z9

Dear Sirs/Madams:

---

| | |
|:---|:---|
| **Re:** | **Voting and Support Agreement** |

---

The undersigned understands that Xeno Acquisition Corp. (the "**Purchaser**"), XenoTherapeutics, Inc., Repare Therapeutics Inc. (the "**Company**") and, solely for purposes of Section 9.15 of the Agreement (as defined below) in respect of certain assurances, XOMA Royalty Corporation have entered into an arrangement agreement dated November 14, 2025 (the "**Agreement**") contemplating an arrangement (the "**Arrangement**") of the Company under Chapter XVI, Division II of the *Business Corporations Act* (Québec), the result of which shall be the acquisition by the Purchaser of all the issued and outstanding common shares of the Company (the "**Shares**").

All capitalized terms used but not otherwise defined herein shall have the respective meanings ascribed to them in the Agreement.

1. The undersigned hereby agrees, from the date hereof until the termination of this letter agreement in
accordance with section 5 below:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) to cause its Subject Securities (as defined below) to be counted as present for purposes of establishing
quorum and to vote or to cause to be voted all of the Subject Securities entitled to vote, including any other such securities of the
Company directly or indirectly acquired by or issued to the undersigned after the date hereof, (i) in favour of the approval of the
Arrangement Resolution, the Alternate Resolution and any proposal to adjourn or postpone the Meeting if such adjournment or postponement
is proposed pursuant to and in compliance with the provisions of the Agreement; and (ii) against any Acquisition Proposal and any
other matter which would reasonably be expected to frustrate, breach, interfere with, prevent or delay the completion of transactions
contemplated in the Agreement;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) no later than ten (10) days prior to the Meeting, to deliver or to cause to be delivered to the Company
duly executed proxies or voting instruction forms voting, as applicable, in favour of the approval of the Arrangement Resolution and the
Alternate Resolution, such proxy or voting instruction forms not to be revoked, amended or withdrawn without the prior written consent
of the Company, and, if applicable, name in such proxy (or proxies) or voting instruction form (or voting instruction forms), as applicable,
those individuals as may be designated by the Company in the Circular for such purpose;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) not to, directly or indirectly (including through any of its Representatives): (i) make, solicit, assist,
initiate, encourage, promote or otherwise facilitate (including by way of furnishing, providing access to or disclosing information or
entering into any form of written or oral agreement, arrangement or understanding) any inquiry, proposal or offer that constitutes or
would reasonably be expected to constitute an Acquisition Proposal; (ii) enter into continue or otherwise participate or engage in or
otherwise facilitate any discussions or negotiations with any person (other than the Purchaser and its affiliates and their respective
Representatives), or otherwise cooperate in any way with, or assist or participate in, encourage or otherwise facilitate, any inquiry,
proposal or offer that constitutes or would reasonably be expected to constitute an Acquisition Proposal, (iii) accept, approve, endorse
or recommend, or publicly propose to accept, approve, endorse or recommend, any Acquisition Proposal; (iv) withdraw support, amend or
modify support in a manner adverse to Purchaser, or propose publicly to withdraw support, from the transactions contemplated by the Agreement,
(v) act jointly or in concert with others with respect to voting securities of the Company for the purpose of opposing or competing with
the Purchaser in connection with the Agreement; or (vi) join in the requisition of any meeting of the securityholders of the Company for
the purpose of considering any resolution related to any Acquisition Proposal;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) to, and to cause each of its affiliates to and to instruct each of its and their Representatives to, immediately
cease and terminate any existing solicitation, knowing encouragement, discussions, negotiations or other activities it is engaged in with
any persons (other than the Purchaser and its affiliates) with respect to any inquiry, proposal or offer that constitutes or would reasonably
be expected to constitute or lead to, an Acquisition Proposal;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) except as contemplated by the Agreement and this letter agreement or as required by Law and/or securities
regulation, not to, directly or indirectly, at any time prior to the Meeting (including for greater certainty any adjournment or postponement
thereof) (i) sell, transfer, gift, assign, grant a participation interest in, option, pledge, hypothecate, grant a security or voting
interest in or otherwise convey or encumber (each, a "**Transfer** "), or enter into any agreement, option or other arrangement
(including any profit sharing arrangement, forward sale or other monetization arrangement) with respect to the Transfer of any of its
Subject Securities to any person; (ii) grant or agree to grant any proxy, power of attorney or other right to vote the Subject Securities,
enter into any voting trust or pooling agreement or arrangement in respect of the Subject Securities; or (iii) agree to take any
of the actions described in the foregoing clauses (i) and (ii); provided that the undersigned may Transfer Subject
Securities to a corporation or other entity directly or indirectly owned or controlled by the undersigned or under common control with
or controlling the undersigned provided that (A) such Transfer shall not relieve or release the undersigned of or from its obligations
under this letter agreement, including, without limitation, the obligation of the undersigned to vote or cause to be voted all Subject
Securities at the Meeting in favour of the approval of the Arrangement Resolution and any other matter necessary for the consummation
of the transactions contemplated by the Agreement, (B) prompt written notice of such Transfer is provided, (C) the transferee
continues to be a corporation or other entity directly or indirectly controlled by the undersigned or under common control with or controlling
the undersigned, at all times prior to the termination of this letter agreement; and (D) the transferee agrees in writing in favour
of the Company to be bound by all of the terms and conditions of this letter agreement as if it were a party hereto. For greater certainty,
this provision shall not apply in respect of any sales, transfers, assignments or dispositions of the Subject Securities that occur on
a date following the date of the Meeting;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) to forthwith revoke any and all previous proxies granted or voting instruction forms delivered, or other
voting agreements or arrangements that may conflict with or be inconsistent with the matters set forth in this letter agreement; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) not to exercise any rights of appraisal or rights of dissent provided under any applicable Laws, including
Dissent Rights, or otherwise in connection with the Arrangement or the transactions contemplated by the Agreement.

2. The undersigned hereby represents and warrants that (a) the undersigned is a legal person duly constituted,
validly existing and in good standing under the laws of the jurisdiction of its formation and has all requisite corporate or other power
and authority to enter into and deliver this letter agreement and to perform its obligations hereunder and no other corporate or other
proceedings on its part are necessary to authorize this letter agreement, (b) this letter agreement has been duly executed and delivered
and is a valid and binding agreement, enforceable against the undersigned in accordance with its terms, and the performance by the undersigned
of its obligations hereunder will not constitute a violation or breach of or default under, or conflict with, its Constating Documents
or any contract, commitment, agreement, understanding or arrangement of any kind to which the undersigned will be a party and by which
the undersigned will be bound at the time of such performance, (c) as of the date hereof, it, or one of its affiliates or associates
is, the sole, registered and/or beneficial owner of the number of Shares or any other securities convertible into or exchangeable or exercisable
for Shares, or any other rights to acquire Shares, as set forth on the signature page to this letter agreement (collectively, "**Subject Securities** "), with good title thereto free of any and all encumbrances and demands of any nature or kind whatsoever, and it
has the sole right to vote (in the case of the Shares) and sell (in the case of transferable Subject Securities) all of the Subject Securities,
(d) no person has any agreement or option, or any right or privilege (whether by law, preemptive or contractual) capable of becoming
an agreement or option for the purchase, acquisition or transfer from the undersigned or the applicable holder of any of the Subject Securities,
(e) no consent, approval, order or authorization of, or declaration or filing with, any Governmental Entity or other person is required
to be obtained by the undersigned in connection with the execution, delivery or performance of this letter agreement, (f) to the undersigned's
knowledge, there is no claim, action, litigation, audit, investigation, lawsuit, arbitration, mediation or other proceeding pending or
threatened against or otherwise affecting the undersigned or this letter agreement which, individually or in the aggregate, would reasonably
be expected to have an adverse effect on or otherwise impair the ability of the undersigned to deliver this letter agreement and to perform
its obligations contemplated hereby, and (g) the only securities of the Company beneficially owned or controlled, directly or indirectly,
by the undersigned on the date hereof are the Subject Securities. The undersigned shall not, directly or indirectly (including through
any of its Representatives), take any action that would make any representation or warranty made herein untrue or incorrect. The undersigned
shall notify Company promptly if any representation or warranty made here becomes untrue or incorrect in any material respect.

3. Each party hereto shall, at the request of the other party, promptly execute and deliver any and all such
further documents and instruments and take or cause to be taken any and all such further actions as may reasonably be required in order
to fully perform and carry out the terms and intent of this letter agreement.

4. Each party hereto agrees that irreparable harm would occur for which money damages would not be an adequate
remedy at Law in the event that any of the provisions of this letter agreement were not performed in accordance with their specific terms
or were otherwise breached. Accordingly, the parties hereto agree that, in the event of any breach or threatened breach of this letter
agreement by a party, the non-breaching party will (so long as the Termination Payment has not been paid in accordance with the Agreement)
be entitled, without the requirement of posting a bond or other security, to equitable relief, including injunctive relief and specific
performance.

5. This letter agreement may terminate at any time upon the mutual written agreement of the parties hereto
and shall automatically terminate and be of no further force or effect upon the earlier of: (i) the Effective Time, (ii) the Board
of Directors making a Change of Recommendation, (iii) upon any amendment being validly made to the Arrangement Agreement that changes
the form of the Consideration in a manner which is materially adverse to the Shareholders, and in the case of the Alternate Resolution,
it being amended, modified, or approved in a manner that is materially adverse to the Shareholders, as determined by the board of directors
of the Company acting reasonably and in good faith, (iv) termination of the Agreement in accordance with its terms or (v) May 14,
2026. 6. This letter agreement shall be governed by the Laws of the Province of Québec and the Laws of Canada
applicable therein. Each party hereto hereby irrevocably attorns to the non-exclusive jurisdiction of the courts of the Province of Québec
in respect of all matters arising under and in relation to this Agreement and the Arrangement and waives any defences to the maintenance
of an action in the Courts of the Province of Québec.

7. The undersigned may not assign, delegate or otherwise Transfer any of its rights, interests or obligations
under this letter agreement without the prior written consent of the Company.

8. Each of the undersigned and the Company hereby consents to the disclosure of the substance of this letter
agreement in any press release, documents filed with the Court in connection with the Arrangement or transactions contemplated by the
Agreement or any filing pursuant to applicable Securities Laws, including the Circular.

9. This letter agreement may be executed in any number of counterparts (including counterparts by electronic
copy) and all such counterparts taken together shall be deemed to constitute one and the same instrument. This letter agreement may only
be amended, supplemented or otherwise modified by written agreement signed by the parties hereto.

10. If the foregoing is in accordance with the Company's understanding and is agreed to by the Company,
please signify the Company's acceptance by the execution of the enclosed copies of this letter agreement where indicated below by
an authorized signatory of the Company and return the same to the undersigned, upon which this letter agreement as so accepted shall constitute
an agreement between the Company and the undersigned.

11. The parties hereby confirm their express wish that this Agreement and all ancillary and related documents
thereto be drafted in the English language. *Les parties aux présentes confirment leur volonté expresse que la présente entente et tous les documents qui y sont accessoires soient rédigés en anglais.* 

**[Remainder of page left intentionally blank. Signature page follows.]**

**[LEGAL NAME OF SECURITYHOLDER]**

---

| | |
|:---|:---|
| &nbsp;&nbsp;By: |  |
|  | &nbsp;&nbsp;Name: |
|  | &nbsp;&nbsp;Title: |
|  | &nbsp;&nbsp;Address for Notice: |

---

Quantity and type of Subject Securities owned (beneficially or otherwise) as of the date hereof:

Shares   <br> Other  

Accepted and agreed on this _____ day of November, 2025.

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;**REPARE THERAPEUTICS INC.** | &nbsp;&nbsp;**REPARE THERAPEUTICS INC.** | &nbsp;&nbsp;**REPARE THERAPEUTICS INC.** |
| &nbsp;&nbsp;By: |  |  |
|  | &nbsp;&nbsp;Name: | &nbsp;&nbsp;Steve Forte |
|  | &nbsp;&nbsp;Title: | &nbsp;&nbsp;Director, President, CEO and CFO |

---

### UNITED STATES SECURITIES AND EXCHANGE COMMISSION
**Washington, D.C. 20549**

## SCHEDULE 13D

### Under the Securities Exchange Act of 1934

**(Amendment No. 2)**

**Repare Therapeutics Inc.**

*(Name of Issuer)*

**Common Shares, no par value**

*(Title of Class of Securities)*

**760273102**

*(CUSIP Number)*

**JAMES KRATKY**<br>BVF PARTNERS L.P.<br>44 Montgomery St., 40th Floor<br>San Francisco CA 94104<br>415-525-8830

*(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)*

**11/20/2025**

*(Date of Event Which Requires Filing of this Statement)*

| **CUSIP No.** | **760273102** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**BIOTECHNOLOGY VALUE FUND L P** | Name of reporting person<br>**BIOTECHNOLOGY VALUE FUND L P** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**WC** | Source of funds (See Instructions)<br>**WC** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**5309432.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**5309432.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**5309432.00** | Aggregate amount beneficially owned by each reporting person<br>**5309432.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**12.4%** | Percent of class represented by amount in Row (11)<br>**12.4%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**PN** | Type of Reporting Person (See Instructions)<br>**PN** | |

---

| **CUSIP No.** | **760273102** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**BVF I GP LLC** | Name of reporting person<br>**BVF I GP LLC** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**5309432.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**5309432.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**5309432.00** | Aggregate amount beneficially owned by each reporting person<br>**5309432.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**12.4%** | Percent of class represented by amount in Row (11)<br>**12.4%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**OO** | Type of Reporting Person (See Instructions)<br>**OO** | |

---

| **CUSIP No.** | **760273102** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**BIOTECHNOLOGY VALUE FUND II LP** | Name of reporting person<br>**BIOTECHNOLOGY VALUE FUND II LP** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**WC** | Source of funds (See Instructions)<br>**WC** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**4308573.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**4308573.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**4308573.00** | Aggregate amount beneficially owned by each reporting person<br>**4308573.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**10.0%** | Percent of class represented by amount in Row (11)<br>**10.0%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**PN** | Type of Reporting Person (See Instructions)<br>**PN** | |

---

| **CUSIP No.** | **760273102** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**BVF II GP LLC** | Name of reporting person<br>**BVF II GP LLC** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**4308573.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**4308573.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**4308573.00** | Aggregate amount beneficially owned by each reporting person<br>**4308573.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**10.0%** | Percent of class represented by amount in Row (11)<br>**10.0%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**OO** | Type of Reporting Person (See Instructions)<br>**OO** | |

---

| **CUSIP No.** | **760273102** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**Biotechnology Value Trading Fund OS LP** | Name of reporting person<br>**Biotechnology Value Trading Fund OS LP** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**WC** | Source of funds (See Instructions)<br>**WC** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**CAYMAN ISLANDS** | Citizenship or place of organization<br>**CAYMAN ISLANDS** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**548938.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**548938.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**548938.00** | Aggregate amount beneficially owned by each reporting person<br>**548938.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**1.3%** | Percent of class represented by amount in Row (11)<br>**1.3%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**PN** | Type of Reporting Person (See Instructions)<br>**PN** | |

---

| **CUSIP No.** | **760273102** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**BVF Partners OS Ltd.** | Name of reporting person<br>**BVF Partners OS Ltd.** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**CAYMAN ISLANDS** | Citizenship or place of organization<br>**CAYMAN ISLANDS** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**548938.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**548938.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**548938.00** | Aggregate amount beneficially owned by each reporting person<br>**548938.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**1.3%** | Percent of class represented by amount in Row (11)<br>**1.3%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**CO** | Type of Reporting Person (See Instructions)<br>**CO** | |

---

| **CUSIP No.** | **760273102** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**BVF GP HOLDINGS LLC** | Name of reporting person<br>**BVF GP HOLDINGS LLC** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**9618005.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**9618005.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**9618005.00** | Aggregate amount beneficially owned by each reporting person<br>**9618005.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**22.4%** | Percent of class represented by amount in Row (11)<br>**22.4%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**OO** | Type of Reporting Person (See Instructions)<br>**OO** | |

---

| **CUSIP No.** | **760273102** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**BVF PARTNERS L P/IL** | Name of reporting person<br>**BVF PARTNERS L P/IL** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**10333600.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**10333600.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**10333600.00** | Aggregate amount beneficially owned by each reporting person<br>**10333600.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**24.0%** | Percent of class represented by amount in Row (11)<br>**24.0%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**IA** | Type of Reporting Person (See Instructions)<br>**IA** | |

---

| **CUSIP No.** | **760273102** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**BVF INC/IL** | Name of reporting person<br>**BVF INC/IL** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**10333600.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**10333600.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**10333600.00** | Aggregate amount beneficially owned by each reporting person<br>**10333600.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**24.0%** | Percent of class represented by amount in Row (11)<br>**24.0%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**CO** | Type of Reporting Person (See Instructions)<br>**CO** | |

---

| **CUSIP No.** | **760273102** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**LAMPERT MARK N** | Name of reporting person<br>**LAMPERT MARK N** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**X1** | Citizenship or place of organization<br>**X1** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**10333600.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**10333600.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**10333600.00** | Aggregate amount beneficially owned by each reporting person<br>**10333600.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**24.0%** | Percent of class represented by amount in Row (11)<br>**24.0%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**IN** | Type of Reporting Person (See Instructions)<br>**IN** | |

---

**Item 1. Security and Issuer**

**(a) Title of Class of Securities:**
Common Shares, no par value

**(b) Name of Issuer:**
Repare Therapeutics Inc.

**(c) Address of Issuer's Principal Executive Offices:**
7171 FREDERICK BANTING, SUITE 270, BUILDING 2, SAINT-LAURENT, A8, H4S 1Z9

**Item 4. Purpose of Transaction**

Item 4 is hereby amended to add the following:

On November 14, 2025, the Issuer entered into an Arrangement Agreement (the "Agreement") with XenoTherapeutics, Inc., a Massachusetts non-profit corporation ("Xeno"), Xeno Acquisition Corp., a Delaware corporation and wholly-owned subsidiary of Xeno ("Purchaser"), and solely for purposes of Section 9.15 thereof, XOMA Royalty Corporation, a Nevada corporation, pursuant to which Purchaser will acquire all of the issued and outstanding Shares (the holders of such Shares, the "Shareholders") of the Issuer (the "Transaction"). Under the terms of the Agreement, the Shareholders will receive a cash payment per Share that will be determined based upon the Issuer's cash balance immediately prior to the closing of the Transaction ("Closing") after deducting certain transaction costs, the aggregate amount of outstanding liabilities, and a transaction fee to Xeno. In addition, each Shareholder will also receive one non-transferable contingent value right (each, a "CVR") for each Share that will entitle the holder to receive a pro rata portion of potential cash payments. The cash payable at Closing is estimated by the Issuer to be approximately $1.82 per Share, exclusive of payments received pursuant to the CVR. The Transaction will be implemented by way of a court-approved plan of arrangement under the Business Corporations Act (Quebec) (such transaction, the "Arrangement").

On November 20, 2025, certain of the Reporting Persons entered into Voting and Support Agreements (the "Voting Agreements") with the Issuer pursuant to which such Reporting Persons agreed, among other things, to vote all voting securities of the Issuer beneficially owned by them in favor of the approval and adoption of the Arrangement and the transactions contemplated therein.

The foregoing description of the Voting Agreements does not purport to be complete and is qualified in its entirety by reference to the full text of a form of the Voting Agreements, a copy of which is attached hereto as Exhibit 99.1 and incorporated herein by reference.

**Item 5. Interest in Securities of the Issuer**

**(a)**
Item 5(a) is hereby amended and restated to read as follows:

The aggregate percentage of Shares reported owned by each person named herein is based on 42,985,755 Shares outstanding as of November 14, 2025, which is the total number of Shares outstanding as reported in Exhibit 2.1 to the Issuer's Current Report on Form 8-K filed with the Securities and Exchange Commission on November 17, 2025.

As of the close of business on the date hereof, (i) BVF beneficially owned 5,309,432 Shares, representing percentage ownership of approximately 12.4% of the Shares outstanding, (ii) BVF2 beneficially owned 4,308,573 Shares, representing percentage ownership of approximately 10.0% of the Shares outstanding, and (iii) Trading Fund OS beneficially owned 548,938 Shares, representing percentage ownership of approximately 1.3% of the Shares outstanding.

BVF GP, as the general partner of BVF, may be deemed to beneficially own the 5,309,432 Shares beneficially owned by BVF, representing percentage ownership of approximately 12.4% of the Shares outstanding.

BVF2 GP, as the general partner of BVF2, may be deemed to beneficially own the 4,308,573 Shares beneficially owned by BVF2, representing percentage ownership of approximately 10.0% of the Shares outstanding.

Partners OS, as the general partner of Trading Fund OS, may be deemed to beneficially own the 548,938 Shares beneficially owned by Trading Fund OS, representing percentage ownership of approximately 1.3% of the Shares outstanding.

BVF GPH, as the sole member of each of BVF GP and BVF2 GP, may be deemed to beneficially own the 9,618,005 Shares beneficially owned in the aggregate by BVF and BVF2, representing percentage ownership of approximately 22.4% of the Shares outstanding.

Partners, as the investment manager of BVF, BVF2 and Trading Fund OS and the Partners Managed Account, and the sole member of Partners OS, may be deemed to beneficially own the 10,333,600 Shares beneficially owned in the aggregate by BVF, BVF2 and Trading Fund OS and held in the Partners Managed Account, including 166,657 Shares held in the Partners Managed Account, representing percentage ownership of approximately 24.0% of the Shares outstanding (less than 1% of the Shares outstanding are held in the Partners Managed Account).

BVF Inc., as the general partner of Partners, may be deemed to beneficially own the 10,333,600 Shares beneficially owned by Partners, representing percentage ownership of approximately 24.0% of the Shares outstanding.

Mr. Lampert, as the sole director and officer of BVF Inc., may be deemed to beneficially own the 10,333,600 Shares beneficially owned by BVF Inc., representing percentage ownership of approximately 24.0% of the Shares outstanding.

The foregoing should not be construed in and of itself as an admission by any Reporting Person as to beneficial ownership of any Shares owned by another Reporting Person. BVF GP disclaims beneficial ownership of the Shares beneficially owned by BVF. BVF2 GP disclaims beneficial ownership of the Shares beneficially owned by BVF2. Partners OS disclaims beneficial ownership of the Shares beneficially owned by Trading Fund OS. BVF GPH disclaims beneficial ownership of the Shares beneficially owned by BVF and BVF2. Each of Partners, BVF Inc. and Mr. Lampert disclaims beneficial ownership of the Shares beneficially owned by BVF, BVF2 and Trading Fund OS and held in the Partners Managed Account.

**(b)**
—

**(c)**
—

**Item 6. Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer.**

Item 6 is hereby amended to add the following:

On November 20, 2025, certain of the Reporting Persons entered into the Voting Agreements, as defined and described in Item 4 above. A form of Voting Agreement is attached hereto as Exhibit 99.1.

### SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** BIOTECHNOLOGY VALUE FUND L P

**Signature:** /s/ Mark N. Lampert

**Name/Title:** Mark N. Lampert, Authorized Signatory

**Date:** 11/24/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** BVF I GP LLC

**Signature:** /s/ Mark N. Lampert

**Name/Title:** Mark N. Lampert, Authorized Signatory

**Date:** 11/24/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** BIOTECHNOLOGY VALUE FUND II LP

**Signature:** /s/ Mark N. Lampert

**Name/Title:** Mark N. Lampert, Authorized Signatory

**Date:** 11/24/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** BVF II GP LLC

**Signature:** /s/ Mark N. Lampert

**Name/Title:** Mark N. Lampert, Authorized Signatory

**Date:** 11/24/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** Biotechnology Value Trading Fund OS LP

**Signature:** /s/ Mark N. Lampert

**Name/Title:** Mark N. Lampert, Authorized Signatory

**Date:** 11/24/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** BVF Partners OS Ltd.

**Signature:** /s/ Mark N. Lampert

**Name/Title:** Mark N. Lampert, Authorized Signatory

**Date:** 11/24/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** BVF GP HOLDINGS LLC

**Signature:** /s/ Mark N. Lampert

**Name/Title:** Mark N. Lampert, Authorized Signatory

**Date:** 11/24/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** BVF PARTNERS L P/IL

**Signature:** /s/ Mark N. Lampert

**Name/Title:** Mark N. Lampert, Authorized Signatory

**Date:** 11/24/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** BVF INC/IL

**Signature:** /s/ Mark N. Lampert

**Name/Title:** Mark N. Lampert, Authorized Signatory

**Date:** 11/24/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** LAMPERT MARK N

**Signature:** /s/ Mark N. Lampert

**Name/Title:** Mark N. Lampert

**Date:** 11/24/2025