# EDGAR Filing Document

**Accession Number:** 0001274413
**File Stem:** 0001104659-23-018063
**Filing Date:** 2023-2
**Character Count:** 15351
**Document Hash:** a5267ff9b163d4a130908ac3a4291116
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-23-018063.hdr.sgml**: 20230210

**ACCESSION NUMBER**: 0001104659-23-018063

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230210

**DATE AS OF CHANGE**: 20230210

**EFFECTIVENESS DATE**: 20230210

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** SECTORAL ASSET MANAGEMENT INC
- **CENTRAL INDEX KEY:** 0001274413
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** A8

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-10653
- **FILM NUMBER:** 23609040

**BUSINESS ADDRESS:**
- **STREET 1:** 1010 SHERBROOKE ST., WEST
- **STREET 2:** SUITE 1610
- **CITY:** MONTREAL
- **STATE:** A8
- **ZIP:** H3A 2R7
- **BUSINESS PHONE:** 514 849 8777

**MAIL ADDRESS:**
- **STREET 1:** 1010 SHERBROOKE ST., WEST
- **STREET 2:** SUITE 1610
- **CITY:** MONTREAL
- **STATE:** A8
- **ZIP:** H3A 2R7

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2022

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** SECTORAL ASSET MANAGEMENT INC<br>**Address:** 1010 Sherbrooke St. West<br>Suite 1610<br>Montreal, A8 H3A 2R7

**Form 13F File Number:** 028-10653

**CRD Number (if applicable):** 000110345

**SEC File Number (if applicable):** 801-60079

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Marc-Andre Marcotte<br>**Title:** Partner  Chief Compliance Officer<br>**Phone:** 1-514-940-8086

**Signature, Place, and Date of Signing:**

/s/ Marc-Andre Marcotte  Montreal, A8  02-06-2023<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 120

**Form 13F Information Table Value Total:** $516778526

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| ABBOTT LABS | COM | 002824100 |  | 3485613 | 31748 | SH |  | SOLE |  | 31748 | 0 | 0 |
| ABBVIE INC | COM | 00287Y109 |  | 6028053 | 37300 | SH |  | SOLE |  | 37300 | 0 | 0 |
| AGILITI INC | COM | 00848J104 |  | 8126001 | 498222 | SH |  | SOLE |  | 122486 | 0 | 375736 |
| ALIGNMENT HEALTHCA | COM | 01625V104 |  | 6456240 | 549000 | SH |  | SOLE |  | 198000 | 0 | 351000 |
| ALNYLAM PHARMACUETCL | COM | 02043Q107 |  | 5420797 | 22810 | SH |  | SOLE |  | 22810 | 0 | 0 |
| ALTIMMUNE INC | COM | 02155H200 |  | 5634125 | 342500 | SH |  | SOLE |  | 145000 | 0 | 197500 |
| AMGEN INC | COM | 031162100 |  | 4706509 | 17920 | SH |  | SOLE |  | 17920 | 0 | 0 |
| AMICUS THERAPEUTICS | COM | 03152W109 |  | 6198797 | 507682 | SH |  | SOLE |  | 21425 | 0 | 486257 |
| AMYLYX PHARMACEUTIC | COM | 03237H101 |  | 5836253 | 157950 | SH |  | SOLE |  | 66319 | 0 | 91631 |
| APELLIS PHARMACEUTIC | COM | 03753U106 |  | 7877501 | 152340 | SH |  | SOLE |  | 40340 | 0 | 112000 |
| ARCUS BIOSCIENCES | COM | 03969F109 |  | 4931808 | 238482 | SH |  | SOLE |  | 59811 | 0 | 178671 |
| ARCUTIS BIOTHERAPE | COM | 03969K108 |  | 3017010 | 203852 | SH |  | SOLE |  | 11400 | 0 | 192452 |
| ARGENX SE | SP ADR | 04016X101 |  | 352312 | 930 | SH |  | SOLE |  | 930 | 0 | 0 |
| ARROWHEAD PHARMACEUT | COM | 04280A100 |  | 3869424 | 95400 | SH |  | SOLE |  | 0 | 0 | 95400 |
| ARVINAS INC | COM | 04335A105 |  | 8184640 | 239247 | SH |  | SOLE |  | 39233 | 0 | 200014 |
| ASCENDIS PHARMA A S | SP ADR | 04351P101 |  | 206400 | 1690 | SH |  | SOLE |  | 1690 | 0 | 0 |
| ASTRAZENECA | SP ADR | 046353108 |  | 1356678 | 20010 | SH |  | SOLE |  | 20010 | 0 | 0 |
| ATEA PHARMACEUTICALS | COM | 04683R106 |  | 1353548 | 281403 | SH |  | SOLE |  | 281403 | 0 | 0 |
| ATRICURE INC | COM | 04963C209 |  | 10053490 | 226532 | SH |  | SOLE |  | 0 | 0 | 226532 |
| AXONICS INC | COM | 05465P101 |  | 5480504 | 87646 | SH |  | SOLE |  | 35696 | 0 | 51950 |
| BEAM THERAPEUTICS | COM | 07373V105 |  | 2483485 | 63500 | SH |  | SOLE |  | 0 | 0 | 63500 |
| BEIGENE LIMITED | SP ADR | 07725L102 |  | 1315241 | 5980 | SH |  | SOLE |  | 5980 | 0 | 0 |
| BELLUS HEALTH INC | COM NEW | 07987C204 |  | 5499418 | 669029 | SH |  | SOLE |  | 217310 | 0 | 451719 |
| BIOMARIN PHARMAC INC | COM | 09061G101 |  | 14362342 | 138780 | SH |  | SOLE |  | 34280 | 0 | 104500 |
| BIOGEN INC | COM | 09062X103 |  | 3697436 | 13352 | SH |  | SOLE |  | 13352 | 0 | 0 |
| BIOXCEL THERAPEUTI | COM | 09075P105 |  | 1313631 | 61156 | SH |  | SOLE |  | 61156 | 0 | 0 |
| BIONTECH SE | SP ADR | 09075V102 |  | 405594 | 2700 | SH |  | SOLE |  | 2700 | 0 | 0 |
| BIOATLA INC | COM | 09077B104 |  | 1140926 | 138294 | SH |  | SOLE |  | 138294 | 0 | 0 |
| BLUEPRINT MEDICINES | COM | 09627Y109 |  | 5077579 | 115900 | SH |  | SOLE |  | 3900 | 0 | 112000 |
| BOSTON SCIENTIFIC | COM | 101137107 |  | 5273670 | 113976 | SH |  | SOLE |  | 113976 | 0 | 0 |
| BRISTOL MYERS SQUIBB | COM | 110122108 |  | 3597500 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| CTI BIOPHARMA CORP | COM | 12648L601 |  | 5891603 | 980300 | SH |  | SOLE |  | 360300 | 0 | 620000 |
| CYTOKINETICS INC | COM | 23282W605 |  | 3823679 | 83450 | SH |  | SOLE |  | 5450 | 0 | 78000 |
| DANAHER CORP | COM | 235851102 |  | 3085508 | 11625 | SH |  | SOLE |  | 11625 | 0 | 0 |
| DENALI THERAPEUTICS | COM | 24823R105 |  | 6781469 | 243850 | SH |  | SOLE |  | 8850 | 0 | 235000 |
| DR REDDYS LABS LTD | ADR | 256135203 |  | 517707 | 10004 | SH |  | SOLE |  | 10004 | 0 | 0 |
| EDWARDS LIFESCIENCE | COM | 28176E108 |  | 2380059 | 31900 | SH |  | SOLE |  | 31900 | 0 | 0 |
| EFFECTOR THERAPEUTCS | COM | 28202V108 |  | 1018819 | 2382644 | SH |  | SOLE |  | 2382644 | 0 | 0 |
| EVOLENT HEALTH INC | CL A | 30050B101 |  | 16444827 | 585642 | SH |  | SOLE |  | 148500 | 0 | 437142 |
| EXELIXIS INC | COM | 30161Q104 |  | 8877739 | 553475 | SH |  | SOLE |  | 18475 | 0 | 535000 |
| EXSCIENTIA PLC | ADS | 30223G102 |  | 1412972 | 265098 | SH |  | SOLE |  | 265098 | 0 | 0 |
| FATE THERAPEUTICS | COM | 31189P102 |  | 1846470 | 183000 | SH |  | SOLE |  | 0 | 0 | 183000 |
| 4D MOLECULAR THERA | COM | 35104E100 |  | 1195698 | 53836 | SH |  | SOLE |  | 53836 | 0 | 0 |
| FUSION PHARMACEUTI | COM | 36118A100 |  | 180486 | 57297 | SH |  | SOLE |  | 57297 | 0 | 0 |
| GALERA THERAPEUTIC | COM | 36338D108 |  | 2483332 | 1666666 | SH |  | SOLE |  | 689175 | 0 | 977491 |
| GENERATION BIO CO | COM | 37148K100 |  | 1075983 | 273787 | SH |  | SOLE |  | 273787 | 0 | 0 |
| GILEAD SCIENCES INC | COM | 375558103 |  | 2236393 | 26050 | SH |  | SOLE |  | 26050 | 0 | 0 |
| GUARDANT HEALTH INC | COM | 40131M109 |  | 129744 | 4770 | SH |  | SOLE |  | 4770 | 0 | 0 |
| HALOZYME THERAPEUTIC | COM | 40637H109 |  | 7818060 | 137400 | SH |  | SOLE |  | 4400 | 0 | 133000 |
| HEALTHEQUITY INC | COM | 42226A107 |  | 15026291 | 243775 | SH |  | SOLE |  | 68400 | 0 | 175375 |
| HUMANA INC | COM | 444859102 |  | 1831079 | 3575 | SH |  | SOLE |  | 3575 | 0 | 0 |
| IRHYTHM TECHNOLOGIES | COM | 450056106 |  | 9005059 | 96136 | SH |  | SOLE |  | 0 | 0 | 96136 |
| ILLUMINA INC | COM | 452327109 |  | 934164 | 4620 | SH |  | SOLE |  | 4620 | 0 | 0 |
| IMMUNOGEN INC | COM | 45253H101 |  | 3987562 | 803944 | SH |  | SOLE |  | 38338 | 0 | 765606 |
| INARI MED INC | COM | 45332Y109 |  | 11488025 | 180743 | SH |  | SOLE |  | 27700 | 0 | 153043 |
| INCYTE CORPORATION | COM | 45337C102 |  | 536538 | 6680 | SH |  | SOLE |  | 6680 | 0 | 0 |
| INSMED INC | COM | 457669307 |  | 10311518 | 516092 | SH |  | SOLE |  | 11621 | 0 | 504471 |
| INSPIRE MED SYS INC | COM | 457730109 |  | 4584216 | 18200 | SH |  | SOLE |  | 0 | 0 | 18200 |
| INTELLIA THERAPEUT | COM | 45826J105 |  | 2490448 | 71380 | SH |  | SOLE |  | 2480 | 0 | 68900 |
| INTRA CELLULAR THERA | COM | 46116X101 |  | 6480054 | 122450 | SH |  | SOLE |  | 5650 | 0 | 116800 |
| IONIS PHARMACEUTICAL | COM | 462222100 |  | 168077 | 4450 | SH |  | SOLE |  | 4450 | 0 | 0 |
| IQVIA HOLDINGS INC | COM | 46266C105 |  | 3093839 | 15100 | SH |  | SOLE |  | 15100 | 0 | 0 |
| ITEOS THERAPEUTICS | COM | 46565G104 |  | 1128092 | 57762 | SH |  | SOLE |  | 57762 | 0 | 0 |
| JOHNSON  JOHNSON | COM | 478160104 |  | 10969965 | 62100 | SH |  | SOLE |  | 62100 | 0 | 0 |
| KARUNA THERAPEUTICS | COM | 48576A100 |  | 4285665 | 21810 | SH |  | SOLE |  | 1410 | 0 | 20400 |
| LANTHEUS HLDGS INC | COM | 516544103 |  | 6761730 | 132687 | SH |  | SOLE |  | 0 | 0 | 132687 |
| LEGEND BIOTECH CORP | SP ADS | 52490G102 |  | 449280 | 9000 | SH |  | SOLE |  | 9000 | 0 | 0 |
| LILLY ELI  CO | COM | 532457108 |  | 6736944 | 18415 | SH |  | SOLE |  | 18415 | 0 | 0 |
| MACROGENICS INC | COM | 556099109 |  | 1343476 | 200220 | SH |  | SOLE |  | 200220 | 0 | 0 |
| MEDPACE HOLDINGS | COM | 58506Q109 |  | 206038 | 970 | SH |  | SOLE |  | 970 | 0 | 0 |
| MERCK  CO INC | COM | 58933Y105 |  | 6102250 | 55000 | SH |  | SOLE |  | 55000 | 0 | 0 |
| MIRATI THERAPEUTICS | COM | 60468T105 |  | 3028792 | 66846 | SH |  | SOLE |  | 30346 | 0 | 36500 |
| MODERNA INC | COM USD | 60770K107 |  | 3182507 | 17718 | SH |  | SOLE |  | 17718 | 0 | 0 |
| NEUROCRINE BIOSCIENC | COM | 64125C109 |  | 334432 | 2800 | SH |  | SOLE |  | 2800 | 0 | 0 |
| OLEMA PHARMACEUTICAL | COM | 68062P106 |  | 3532422 | 1441805 | SH |  | SOLE |  | 572813 | 0 | 868992 |
| OPTION CARE HEALTH | COM | 68404L201 |  | 8229615 | 273500 | SH |  | SOLE |  | 73500 | 0 | 200000 |
| OUTSET MED INC | COM | 690145107 |  | 3614800 | 140000 | SH |  | SOLE |  | 0 | 0 | 140000 |
| PTC THERAPEUTICS I | COM | 69366J200 |  | 8683331 | 227491 | SH |  | SOLE |  | 6000 | 0 | 221491 |
| PFIZER INC | COM | 717081103 |  | 6630456 | 129400 | SH |  | SOLE |  | 129400 | 0 | 0 |
| POINT BIOPHARMA GBL | COM | 730541109 |  | 1350677 | 185278 | SH |  | SOLE |  | 185278 | 0 | 0 |
| PRIVIA HEALTH GROUP | COM | 74276R102 |  | 7296996 | 321312 | SH |  | SOLE |  | 0 | 0 | 321312 |
| PROMETHEUS BIOSCIENC | COM | 74349U108 |  | 12343100 | 112210 | SH |  | SOLE |  | 32750 | 0 | 79460 |
| RADNET INC | COM | 750491102 |  | 5591248 | 296933 | SH |  | SOLE |  | 117500 | 0 | 179433 |
| RAIN ONCOLOGY INC | COM | 75082Q105 |  | 150400 | 18800 | SH |  | SOLE |  | 18800 | 0 | 0 |
| RALLYBIO CORP | COM | 75120L100 |  | 4072684 | 619891 | SH |  | SOLE |  | 175977 | 0 | 443914 |
| REGENERON PHARMCTCLS | COM | 75886F107 |  | 1955238 | 2710 | SH |  | SOLE |  | 2710 | 0 | 0 |
| REPLIMUNE GROUP INC | COM | 76029N106 |  | 5344800 | 196500 | SH |  | SOLE |  | 77016 | 0 | 119484 |
| ROCKET PHARMACEUTICA | COM | 77313F106 |  | 3733760 | 190790 | SH |  | SOLE |  | 0 | 0 | 190790 |
| R1 RCM INC | COM | 77634L105 |  | 14810357 | 1352544 | SH |  | SOLE |  | 382444 | 0 | 970100 |
| SPDR SER TR | S BIOTECH | 78464A870 |  | 1285006 | 15482 | SH |  | SOLE |  | 15482 | 0 | 0 |
| SANOFI | SP ADR | 80105N105 |  | 431027 | 8900 | SH |  | SOLE |  | 8900 | 0 | 0 |
| SAREPTA THERAPEUTICS | COM | 803607100 |  | 362824 | 2800 | SH |  | SOLE |  | 2800 | 0 | 0 |
| SCHOLAR ROCK HLDG | COM | 80706P103 |  | 1368423 | 151207 | SH |  | SOLE |  | 151207 | 0 | 0 |
| SEAGEN INC | COM | 81181C104 |  | 5164817 | 40190 | SH |  | SOLE |  | 40190 | 0 | 0 |
| SHOCKWAVE MEDICAL | COM | 82489T104 |  | 8039351 | 39100 | SH |  | SOLE |  | 0 | 0 | 39100 |
| SILK ROAD MEDICAL | COM | 82710M100 |  | 4470529 | 84589 | SH |  | SOLE |  | 0 | 0 | 84589 |
| ARS PHARMACEUTICALS | COM | 82835W108 |  | 6673957 | 782410 | SH |  | SOLE |  | 412258 | 0 | 370152 |
| STAAR SURGICAL CO | COM | 852312305 |  | 2135760 | 44000 | SH |  | SOLE |  | 0 | 0 | 44000 |
| STRYKER CORP | COM | 863667101 |  | 2273757 | 9300 | SH |  | SOLE |  | 9300 | 0 | 0 |
| TENET HEALTHCARE | COM | 88033G407 |  | 4952185 | 101500 | SH |  | SOLE |  | 0 | 0 | 101500 |
| THERMO FISHER SCI | COM | 883556102 |  | 4386246 | 7965 | SH |  | SOLE |  | 7965 | 0 | 0 |
| TRAVERE THERAPEUTICS | COM | 89422G107 |  | 6147490 | 292320 | SH |  | SOLE |  | 88128 | 0 | 204192 |
| TREACE MED CONCEPT | COM | 89455T109 |  | 4136453 | 179924 | SH |  | SOLE |  | 47400 | 0 | 132524 |
| UNITED THERAPEUTICS | COM | 91307C102 |  | 504733 | 1815 | SH |  | SOLE |  | 1815 | 0 | 0 |
| UNITEDHEALTH GRP INC | COM | 91324P102 |  | 13400300 | 25275 | SH |  | SOLE |  | 25275 | 0 | 0 |
| VAXCYTE INC | COM | 92243G108 |  | 2877000 | 60000 | SH |  | SOLE |  | 0 | 0 | 60000 |
| VERTEX PHARMACEUTICL | COM | 92532F100 |  | 2026947 | 7019 | SH |  | SOLE |  | 7019 | 0 | 0 |
| ZAI LAB LTD | ADR | 98887Q104 |  | 412055 | 13422 | SH |  | SOLE |  | 13422 | 0 | 0 |
| ZENTALIS PHARMACEU | COM | 98943L107 |  | 4048140 | 201000 | SH |  | SOLE |  | 0 | 0 | 201000 |
| ZYMEWORKS INC | COM | 98985Y108 |  | 1510095 | 192124 | SH |  | SOLE |  | 192124 | 0 | 0 |
| ALKERMES PLC | SHS | G01767105 |  | 6059547 | 231900 | SH |  | SOLE |  | 10900 | 0 | 221000 |
| HORIZON THERAPEUTICS | SHS | G46188101 |  | 773840 | 6800 | SH |  | SOLE |  | 6800 | 0 | 0 |
| ICON PLC | SHS | G4705A100 |  | 11004263 | 56650 | SH |  | SOLE |  | 17950 | 0 | 38700 |
| JAZZ PHARMA PLC | SHS USD | G50871105 |  | 313841 | 1970 | SH |  | SOLE |  | 1970 | 0 | 0 |
| MEDTRONIC PLC | SHS | G5960L103 |  | 2452144 | 31551 | SH |  | SOLE |  | 31551 | 0 | 0 |
| NOVOCURE LTD | ORD SHS | G6674U108 |  | 117360 | 1600 | SH |  | SOLE |  | 1600 | 0 | 0 |
| PROTHENA CORP PLC | SHS | G72800108 |  | 6940800 | 115200 | SH |  | SOLE |  | 33704 | 0 | 81496 |
| ROIVANT SCIENCES LTD | SHS | G76279101 |  | 167790 | 21000 | SH |  | SOLE |  | 21000 | 0 | 0 |
| ROYALTY PHARMA PLC | SHS CLASS A | G7709Q104 |  | 491629 | 12440 | SH |  | SOLE |  | 12440 | 0 | 0 |
| CRISPR THERAPEUTICS | NAMEN AKT | H17182108 |  | 101219 | 2490 | SH |  | SOLE |  | 2490 | 0 | 0 |

---