# EDGAR Filing Document

**Accession Number:** 0001631134
**File Stem:** 0001104659-26-062256
**Filing Date:** 2026-5
**Character Count:** 11374
**Document Hash:** de4fa664cfa5a2184b3ea4e5864ac504
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-26-062256.hdr.sgml**: 20260515

**ACCESSION NUMBER**: 0001104659-26-062256

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20260331

**FILED AS OF DATE**: 20260515

**DATE AS OF CHANGE**: 20260515

**EFFECTIVENESS DATE**: 20260515

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Sofinnova Investments, Inc.
- **CENTRAL INDEX KEY:** 0001631134

**ORGANIZATION NAME:**
- **EIN:** 000000000

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-18774
- **FILM NUMBER:** 26985341

**BUSINESS ADDRESS:**
- **STREET 1:** 3000 Sand Hill Road
- **STREET 2:** BUILDING 3-SUITE 150
- **CITY:** Menlo Park
- **STATE:** CA
- **ZIP:** 94025
- **BUSINESS PHONE:** 650.681.8428

**MAIL ADDRESS:**
- **STREET 1:** 3000 Sand Hill Road
- **STREET 2:** BUILDING 3-SUITE 150
- **CITY:** Menlo Park
- **STATE:** CA
- **ZIP:** 94025

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Sofinnova Ventures Inc
- **DATE OF NAME CHANGE:** 20150120

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 03-31-2026

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** Sofinnova Investments Inc.<br>**Address:** 3000 Sand Hill Road<br>BUILDING 3-SUITE 150<br>Menlo Park, CA 94025

**Form 13F File Number:** 028-18774

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Nathalie Auber<br>**Title:** Attorney-in-Fact<br>**Phone:** 650-681-8428

**Signature, Place, and Date of Signing:**

/s/ Nathalie Auber  Menlo Park, CA  05-15-2026<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 75

**Form 13F Information Table Value Total:** $2631154214

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| Acadia Pharmaceuticals Inc | COM | 004225108 |  | 1748545 | 78551 | SH |  | SOLE |  | 78551 | 0 | 0 |
| Alcon AG | ORD SHS | H01301128 |  | 55003390 | 729972 | SH |  | SOLE |  | 729972 | 0 | 0 |
| AnaptysBio Inc | COM | 032724106 |  | 13768111 | 248253 | SH |  | SOLE |  | 248253 | 0 | 0 |
| Arcus Biosciences Inc | COM | 03969F109 |  | 19938658 | 923086 | SH |  | SOLE |  | 923086 | 0 | 0 |
| AstraZeneca PLC | ORD | G0593M107 |  | 89938434 | 456031 | SH |  | SOLE |  | 456031 | 0 | 0 |
| AxoGen Inc | COM | 05463X106 |  | 6979331 | 210665 | SH |  | SOLE |  | 210665 | 0 | 0 |
| Axsome Therapeutics Inc. | COM | 05464T104 |  | 33804000 | 200000 | SH | Put | SOLE |  | 200000 | 0 | 0 |
| Axsome Therapeutics Inc. | COM | 05464T104 |  | 35958498 | 212747 | SH |  | SOLE |  | 212747 | 0 | 0 |
| BioMarin Pharmaceutical Inc | COM | 09061G101 |  | 44174163 | 781982 | SH |  | SOLE |  | 781982 | 0 | 0 |
| Biogen Inc | COM | 09062X103 |  | 42078085 | 229521 | SH |  | SOLE |  | 229521 | 0 | 0 |
| BridgeBio Pharma Inc | COM | 10806X102 |  | 30385930 | 409183 | SH |  | SOLE |  | 409183 | 0 | 0 |
| Bristol-Myers Squibb Co | COM | 110122108 |  | 120615929 | 1988721 | SH |  | SOLE |  | 1988721 | 0 | 0 |
| Celcuity Inc | COM | 15102K100 |  | 41795215 | 366175 | SH |  | SOLE |  | 366175 | 0 | 0 |
| Celcuity Inc | COM | 15102K100 |  | 34242000 | 300000 | SH | Put | SOLE |  | 300000 | 0 | 0 |
| Cogent Biosciences Inc | COM | 19240Q201 |  | 81350578 | 2113551 | SH |  | SOLE |  | 2113551 | 0 | 0 |
| Compass Therapeutics Inc | COM | 20454B104 |  | 10877092 | 2056161 | SH |  | SOLE |  | 2056161 | 0 | 0 |
| Compass Therapeutics Inc | COM | 20454B104 |  | 2645000 | 500000 | SH | Call | SOLE |  | 500000 | 0 | 0 |
| Cytokinetics Inc | COM | 23282W605 |  | 6049945 | 91791 | SH |  | SOLE |  | 91791 | 0 | 0 |
| Definium Therapeutics Inc | COM SHS | 24477V105 |  | 6504737 | 344166 | SH |  | SOLE |  | 344166 | 0 | 0 |
| Dexcom Inc | COM | 252131107 |  | 24716573 | 393576 | SH |  | SOLE |  | 393576 | 0 | 0 |
| Disc Medicine Inc | COM | 254604101 |  | 5007781 | 78320 | SH |  | SOLE |  | 78320 | 0 | 0 |
| Dyne Therapeutics Inc | COM | 26818M108 |  | 29622553 | 1633897 | SH |  | SOLE |  | 1633897 | 0 | 0 |
| Edgewise Therapeutics Inc | COM | 28036F105 |  | 12174687 | 386498 | SH |  | SOLE |  | 386498 | 0 | 0 |
| Establishment Labs Hldgs Inc | COM | G31249108 |  | 1926545 | 33930 | SH |  | SOLE |  | 33930 | 0 | 0 |
| Exelixis Inc | COM | 30161Q104 |  | 10786835 | 251500 | SH | Put | SOLE |  | 251500 | 0 | 0 |
| Genmab A/S | SPONSORED ADS | 372303206 |  | 20183163 | 752261 | SH |  | SOLE |  | 752261 | 0 | 0 |
| Harmony Biosciences Hldgs Inc | COM | 413197104 |  | 4276987 | 152695 | SH |  | SOLE |  | 152695 | 0 | 0 |
| IDEAYA Biosciences Inc | COM | 45166A102 |  | 37711110 | 1131786 | SH |  | SOLE |  | 1131786 | 0 | 0 |
| Immatics N.V | SHS | N44445109 |  | 35723667 | 3630454 | SH |  | SOLE |  | 3630454 | 0 | 0 |
| Immunome Inc | COM | 45257U108 |  | 37220640 | 1701904 | SH |  | SOLE |  | 1701904 | 0 | 0 |
| Inhibrx Biosciences Inc | COM | 45720N103 |  | 27297330 | 406029 | SH |  | SOLE |  | 406029 | 0 | 0 |
| Insmed Inc | COM PAR $.01 | 457669307 |  | 56590184 | 346075 | SH |  | SOLE |  | 346075 | 0 | 0 |
| Invesco QQQ TR | UNIT SER 1 | 46090E103 |  | 86577000 | 150000 | SH | Put | SOLE |  | 150000 | 0 | 0 |
| Jazz Pharmaceuticals PLC | SHS USD | G50871105 |  | 113113719 | 598327 | SH |  | SOLE |  | 598327 | 0 | 0 |
| Liquidia Corporation | COM | 53635D202 |  | 18870000 | 500000 | SH | Put | SOLE |  | 500000 | 0 | 0 |
| Mirum Pharmaceuticals Inc | COM | 604749101 |  | 2548857 | 27591 | SH |  | SOLE |  | 27591 | 0 | 0 |
| Nektar Therapeutics | COM | 640268306 |  | 36661835 | 509546 | SH |  | SOLE |  | 509546 | 0 | 0 |
| Onkure Therapeutics Inc | COM CL A | 68277Q105 |  | 586638 | 141700 | SH |  | SOLE |  | 141700 | 0 | 0 |
| Oric Pharmaceuticals Inc | COM | 68622P109 |  | 8610253 | 679578 | SH |  | SOLE |  | 679578 | 0 | 0 |
| Pfizer Inc | COM | 717081103 |  | 22464000 | 800000 | SH | Call | SOLE |  | 800000 | 0 | 0 |
| Pharvaris N V | COM | N69605108 |  | 23117766 | 818328 | SH |  | SOLE |  | 818328 | 0 | 0 |
| Praxis Precision Medicines Inc | COM | 74006W207 |  | 20517059 | 63680 | SH |  | SOLE |  | 63680 | 0 | 0 |
| Replimune Group Inc | COM | 76029N106 |  | 3919095 | 512300 | SH | Call | SOLE |  | 512300 | 0 | 0 |
| Replimune Group Inc | COM | 76029N106 |  | 3848715 | 503100 | SH | Call | SOLE |  | 503100 | 0 | 0 |
| Rhythm Pharmaceuticals Inc | COM | 76243J105 |  | 39144849 | 450096 | SH |  | SOLE |  | 450096 | 0 | 0 |
| Roivant Sciences Ltd | SHS | G76279101 |  | 13240462 | 477995 | SH |  | SOLE |  | 477995 | 0 | 0 |
| SPDR Series Trust | STATE STREET SPD | 78464A870 |  | 134116500 | 1050000 | SH | Put | SOLE |  | 1050000 | 0 | 0 |
| Savara Inc | COM | 805111101 |  | 1991606 | 364763 | SH |  | SOLE |  | 364763 | 0 | 0 |
| Septerna Inc | COM | 81734D104 |  | 1141569 | 47506 | SH |  | SOLE |  | 47506 | 0 | 0 |
| Soleno Therapeutics Inc | COM | 834203309 |  | 491788 | 14689 | SH |  | SOLE |  | 14689 | 0 | 0 |
| Stryker Corporation | COM | 863667101 |  | 14615683 | 44480 | SH |  | SOLE |  | 44480 | 0 | 0 |
| Supernus Pharmaceuticals | COM | 868459108 |  | 49328232 | 954309 | SH |  | SOLE |  | 954309 | 0 | 0 |
| Tango Therapeutics Inc | COM | 87583X109 |  | 8265095 | 395081 | SH |  | SOLE |  | 395081 | 0 | 0 |
| Tenax Therapeutics Inc | COM | 88032L605 |  | 1669356 | 104400 | SH |  | SOLE |  | 104400 | 0 | 0 |
| Tyra Biosciences Inc | COM | 90240B106 |  | 7813775 | 204015 | SH |  | SOLE |  | 204015 | 0 | 0 |
| Ultragenyx Pharmaceutical Inc | COM | 90400D108 |  | 65906354 | 3145888 | SH |  | SOLE |  | 3145888 | 0 | 0 |
| Ultragenyx Pharmaceutical Inc | COM | 90400D108 |  | 7332500 | 350000 | SH | Call | SOLE |  | 350000 | 0 | 0 |
| United Therapeutics Corp | COM | 91307C102 |  | 47616294 | 80300 | SH | Put | SOLE |  | 80300 | 0 | 0 |
| United Therapeutics Corp | COM | 91307C102 |  | 94918309 | 160070 | SH |  | SOLE |  | 160070 | 0 | 0 |
| Vaxcyte Inc | COM | 92243G108 |  | 2940366 | 50600 | SH |  | SOLE |  | 50600 | 0 | 0 |
| Veradermics Inc | COMMON STOCK | 922967104 |  | 4629842 | 73315 | SH |  | SOLE |  | 73315 | 0 | 0 |
| Wave Life Sciences Ltd | SHS | Y95308105 |  | 1372084 | 189253 | SH |  | SOLE |  | 189253 | 0 | 0 |
| Xenon Pharmaceuticals Inc | COM | 98420N105 |  | 17748310 | 305216 | SH |  | SOLE |  | 305216 | 0 | 0 |
| Zymeworks Inc | COM | 98985Y108 |  | 40314 | 1610 | SH |  | SOLE |  | 1610 | 0 | 0 |
| iShares TR | RUSSELL 2000 ETF | 464287655 |  | 148800000 | 600000 | SH | Put | SOLE |  | 600000 | 0 | 0 |
| iShares TR | ISHARES BIOTECH | 464287556 |  | 80203750 | 475000 | SH | Put | SOLE |  | 475000 | 0 | 0 |
| Arrivent BioPharma Inc | COM | 04272N102 |  | 39144069 | 1696752 | SH |  | SOLE |  | 1696752 | 0 | 0 |
| BioAge Labs Inc | COM | 09077V100 |  | 40118352 | 2293788 | SH |  | SOLE |  | 2293788 | 0 | 0 |
| Bolt Biotherapeutics Inc | COM | 097702203 |  | 556393 | 137721 | SH |  | SOLE |  | 137721 | 0 | 0 |
| ImageneBio Inc | COM | 45175G207 |  | 159420 | 31884 | SH |  | SOLE |  | 31884 | 0 | 0 |
| Jade Biosciences Inc | COM | 008064206 |  | 1508844 | 107391 | SH |  | SOLE |  | 107391 | 0 | 0 |
| Natera Inc | COM | 632307104 |  | 310040497 | 1550280 | SH |  | SOLE |  | 1550280 | 0 | 0 |
| Nextcure Inc | COM | 65343E207 |  | 2377945 | 222654 | SH |  | SOLE |  | 222654 | 0 | 0 |
| Rapport Therapeutics Inc | COM | 75383L102 |  | 59588926 | 1904408 | SH |  | SOLE |  | 1904408 | 0 | 0 |
| Vera Therapeutics Inc | CL A | 92337R101 |  | 112402097 | 2793987 | SH |  | SOLE |  | 2793987 | 0 | 0 |

---