# EDGAR Filing Document

**Accession Number:** 0001374690
**File Stem:** 0001193805-23-000345
**Filing Date:** 2023-3
**Character Count:** 37821
**Document Hash:** fa18cc58269a4d603753fee02b4d7cb2
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193805-23-000345.hdr.sgml**: 20230317

**ACCESSION NUMBER**: 0001193805-23-000345

**CONFORMED SUBMISSION TYPE**: SC 13D/A

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20230317

**DATE AS OF CHANGE**: 20230316

**GROUP MEMBERS**: DEERFIELD HEALTHCARE INNOVATIONS FUND, L.P.

**GROUP MEMBERS**: DEERFIELD MANAGEMENT COMPANY, L.P.

**GROUP MEMBERS**: DEERFIELD MGMT HIF, L.P.

**GROUP MEMBERS**: DEERFIELD MGMT III, L.P.

**GROUP MEMBERS**: DEERFIELD MGMT, IV, L.P.

**GROUP MEMBERS**: DEERFIELD MGMT, L.P.

**GROUP MEMBERS**: DEERFIELD PARTNERS, L.P.

**GROUP MEMBERS**: DEERFIELD PRIVATE DESIGN FUND III, L.P.

**GROUP MEMBERS**: DEERFIELD PRIVATE DESIGN FUND IV, L.P.

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Larimar Therapeutics, Inc.
- **CENTRAL INDEX KEY:** 0001374690
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 203857670
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13D/A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-88225
- **FILM NUMBER:** 23739999

**BUSINESS ADDRESS:**
- **STREET 1:** THREE BALA PLAZA EAST. SUITE 506
- **CITY:** BALA CYNWYD
- **STATE:** PA
- **ZIP:** 19004
- **BUSINESS PHONE:** 844-511-9056

**MAIL ADDRESS:**
- **STREET 1:** THREE BALA PLAZA EAST. SUITE 506
- **CITY:** BALA CYNWYD
- **STATE:** PA
- **ZIP:** 19004

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ZAFGEN, INC.
- **DATE OF NAME CHANGE:** 20100301

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ZAFGEN INC
- **DATE OF NAME CHANGE:** 20060906
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Flynn James E
- **CENTRAL INDEX KEY:** 0001352546

**FILING VALUES:**
- **FORM TYPE:** SC 13D/A

**MAIL ADDRESS:**
- **STREET 1:** 780 THIRD AVENUE
- **STREET 2:** 37TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10017

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**SCHEDULE 13D**

[Rule 13d-101]

INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 24.13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13D-2(a)

(Amendment No. 6)\*

**Larimar Therapeutics, Inc.**

(Name of Issuer)

**Common Stock, par value $0.01 per share**

(Title of Class of Securities)

**517125100**

(CUSIP Number)

**David Clark**<br> **Elliot Press**<br> **Deerfield Management Company, L.P.**<br> **345 Park Avenue South, 12 Floor**<br> **New York, New York 10010**<br> (212) 551-1600<br>**With a copy to:**<br>**Jonathan D. Weiner, Esq.**<br> **Mark D. Wood, Esq.**<br> **Katten Muchin Rosenman LLP**<br> **50 Rockefeller Plaza**<br> **New York, New York 10021**<br> (212) 940-8800<br>

(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)

**March 14, 2023**

(Date of Event which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box ☐.

*Note*: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See § 240.13d-7 for other parties to whom copies are to be sent.

(Continued on following pages)<br> (Page 1 of 17 Pages)

\* The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1734 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

SCHEDULE 13D

<u>CUSIP No. <u>517125100</u></u> <u>Page 2 of 17 Pages</u>

---

| | | | |
|:---|:---|:---|:---|
| **1** | NAMES OF REPORTING PERSONS<br>Deerfield Private Design Fund III, L.P. | NAMES OF REPORTING PERSONS<br>Deerfield Private Design Fund III, L.P. |  |
| **2** | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP\* | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP\* | (a) ☐<br> (b) ☒ |
| **3** | SEC USE ONLY | SEC USE ONLY |  |
| **4** | SOURCE OF FUNDS<br>WC | SOURCE OF FUNDS<br>WC |  |
| **5** | CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) | CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) | ☐ |
| **6** | CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware | CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **7** | SOLE VOTING POWER<br>0 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **8** | SHARED VOTING POWER<br>4,721,183 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **9**<br>| SOLE DISPOSITIVE POWER<br>0 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **10**<br>| SHARED DISPOSITIVE POWER<br>4,721,183 |  |
| **11**<br>| AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>4,721,183 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>4,721,183 |  |
| **12** | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES\* | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES\* | ☐ |
| **13**<br>| PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>10.91% | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>10.91% |  |
| **14** | TYPE OF REPORTING PERSON<br>PN | TYPE OF REPORTING PERSON<br>PN |  |

---

SCHEDULE 13D

<u>CUSIP No. <u>517125100</u></u> <u>Page 3 of 17 Pages</u>

---

| | | | |
|:---|:---|:---|:---|
| **1** | NAMES OF REPORTING PERSONS<br>Deerfield Healthcare Innovations Fund, L.P. | NAMES OF REPORTING PERSONS<br>Deerfield Healthcare Innovations Fund, L.P. |  |
| **2** | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP\* | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP\* | (a) ☐<br> (b) ☒ |
| **3** | SEC USE ONLY | SEC USE ONLY |  |
| **4** | SOURCE OF FUNDS<br>WC | SOURCE OF FUNDS<br>WC |  |
| **5** | CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) | CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) | ☐ |
| **6** | CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware | CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **7** | SOLE VOTING POWER<br>0 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **8** | SHARED VOTING POWER<br>4,721,197 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **9**<br>| SOLE DISPOSITIVE POWER<br>0 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **10**<br>| SHARED DISPOSITIVE POWER<br>4,721,197 |  |
| **11**<br>| AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>4,721,197 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>4,721,197 |  |
| **12** | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES\* | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES\* | ☐ |
| **13**<br>| PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>10.91% | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>10.91% |  |
| **14** | TYPE OF REPORTING PERSON<br>PN | TYPE OF REPORTING PERSON<br>PN |  |

---

SCHEDULE 13D

<u>CUSIP No. <u>517125100</u></u> <u>Page 4 of 17 Pages</u>

---

| | | | |
|:---|:---|:---|:---|
| **1** | NAMES OF REPORTING PERSONS<br>Deerfield Private Design Fund IV, L.P. | NAMES OF REPORTING PERSONS<br>Deerfield Private Design Fund IV, L.P. |  |
| **2** | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP\* | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP\* | (a) ☐<br> (b) ☒ |
| **3** | SEC USE ONLY | SEC USE ONLY |  |
| **4** | SOURCE OF FUNDS<br>WC | SOURCE OF FUNDS<br>WC |  |
| **5** | CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) | CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) | ☐ |
| **6** | CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware | CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **7** | SOLE VOTING POWER<br>0 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **8** | SHARED VOTING POWER<br>4,721,200 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **9**<br>| SOLE DISPOSITIVE POWER<br>0 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **10**<br>| SHARED DISPOSITIVE POWER<br>4,721,200 |  |
| **11**<br>| AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>4,721,200 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>4,721,200 |  |
| **12** | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES\* | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES\* | ☐ |
| **13**<br>| PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>10.91% | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>10.91% |  |
| **14** | TYPE OF REPORTING PERSON<br>PN | TYPE OF REPORTING PERSON<br>PN |  |

---

SCHEDULE 13D

<u>CUSIP No. <u>517125100</u></u> <u>Page 5 of 17 Pages</u>

---

| | | | |
|:---|:---|:---|:---|
| **1** | NAMES OF REPORTING PERSONS<br>Deerfield Partners, L.P. | NAMES OF REPORTING PERSONS<br>Deerfield Partners, L.P. |  |
| **2** | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP\* | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP\* | (a) ☐<br> (b) ☒ |
| **3** | SEC USE ONLY | SEC USE ONLY |  |
| **4** | SOURCE OF FUNDS<br>WC | SOURCE OF FUNDS<br>WC |  |
| **5** | CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) | CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) | ☐ |
| **6** | CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware | CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **7** | SOLE VOTING POWER<br>0 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **8** | SHARED VOTING POWER<br>2,777,777 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **9**<br>| SOLE DISPOSITIVE POWER<br>0 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **10**<br>| SHARED DISPOSITIVE POWER<br>2,777,777 |  |
| **11**<br>| AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>2,777,777 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>2,777,777 |  |
| **12** | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES\* | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES\* | ☐ |
| **13**<br>| PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>6.42% | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>6.42% |  |
| **14** | TYPE OF REPORTING PERSON<br>PN | TYPE OF REPORTING PERSON<br>PN |  |

---

SCHEDULE 13D

<u>CUSIP No. <u>517125100</u></u> <u>Page 6 of 17 Pages</u>

---

| | | | |
|:---|:---|:---|:---|
| **1** | NAMES OF REPORTING PERSONS<br>Deerfield Mgmt III, L.P. | NAMES OF REPORTING PERSONS<br>Deerfield Mgmt III, L.P. |  |
| **2** | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP\* | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP\* | (a) ☐<br> (b) ☒ |
| **3** | SEC USE ONLY | SEC USE ONLY |  |
| **4** | SOURCE OF FUNDS<br>AF | SOURCE OF FUNDS<br>AF |  |
| **5** | CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) | CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) | ☐ |
| **6** | CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware | CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **7** | SOLE VOTING POWER<br>0 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **8** | SHARED VOTING POWER<br>4,721,183 (1) |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **9**<br>| SOLE DISPOSITIVE POWER<br>0 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **10**<br>| SHARED DISPOSITIVE POWER<br>4,721,183 (1) |  |
| **11**<br>| AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>4,721,183 (1) | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>4,721,183 (1) |  |
| **12** | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES\* | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES\* | ☐ |
| **13**<br>| PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>10.91% | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>10.91% |  |
| **14** | TYPE OF REPORTING PERSON<br>PN | TYPE OF REPORTING PERSON<br>PN |  |

---

(1) Comprised of shares of common stock held by Deerfield Private Design
Fund III, L.P., of which Deerfield Mgmt III, L.P. is the general partner.

SCHEDULE 13D

<u>CUSIP No. <u>517125100</u></u> <u>Page 7 of 17 Pages</u>

---

| | | | |
|:---|:---|:---|:---|
| **1** | NAMES OF REPORTING PERSONS<br>Deerfield Mgmt HIF, L.P. | NAMES OF REPORTING PERSONS<br>Deerfield Mgmt HIF, L.P. |  |
| **2** | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP\* | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP\* | (a) ☐<br> (b) ☒ |
| **3** | SEC USE ONLY | SEC USE ONLY |  |
| **4** | SOURCE OF FUNDS<br>AF | SOURCE OF FUNDS<br>AF |  |
| **5** | CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) | CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) | ☐ |
| **6** | CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware | CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **7** | SOLE VOTING POWER<br>0 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **8** | SHARED VOTING POWER<br>4,721,197 (2) |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **9**<br>| SOLE DISPOSITIVE POWER<br>0 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **10**<br>| SHARED DISPOSITIVE POWER<br>4,721,197 (2) |  |
| **11**<br>| AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>4,721,197 (2) | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>4,721,197 (2) |  |
| **12** | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES\* | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES\* | ☐ |
| **13**<br>| PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>10.91% | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>10.91% |  |
| **14** | TYPE OF REPORTING PERSON<br>PN | TYPE OF REPORTING PERSON<br>PN |  |

---

(2) Comprised of shares of common stock held by Deerfield Healthcare Innovations
Fund, L.P., of which Deerfield Mgmt HIF, L.P. is the general partner.

SCHEDULE 13D

<u>CUSIP No. <u>517125100</u></u> <u>Page 8 of 17 Pages</u>

---

| | | | |
|:---|:---|:---|:---|
| **1** | NAMES OF REPORTING PERSONS<br>Deerfield Mgmt, IV, L.P. | NAMES OF REPORTING PERSONS<br>Deerfield Mgmt, IV, L.P. |  |
| **2** | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP\* | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP\* | (a) ☐<br> (b) ☒ |
| **3** | SEC USE ONLY | SEC USE ONLY |  |
| **4** | SOURCE OF FUNDS<br>AF | SOURCE OF FUNDS<br>AF |  |
| **5** | CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) | CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) | ☒ |
| **6** | CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware | CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **7** | SOLE VOTING POWER<br>0 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **8** | SHARED VOTING POWER<br>4,721,200 (3) |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **9**<br>| SOLE DISPOSITIVE POWER<br>0 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **10**<br>| SHARED DISPOSITIVE POWER<br>4,721,200 (3) |  |
| **11**<br>| AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>4,721,200 (3) | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>4,721,200 (3) |  |
| **12** | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES\* | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES\* | ☐ |
| **13**<br>| PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>10.91% | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>10.91% |  |
| **14** | TYPE OF REPORTING PERSON<br>PN | TYPE OF REPORTING PERSON<br>PN |  |

---

(3) Comprised of shares of common stock held by Deerfield Private Design
Fund IV, L.P., of which Deerfield Mgmt IV, L.P. is the general partner.

SCHEDULE 13D

<u>CUSIP No. <u>517125100</u></u> <u>Page 9 of 17 Pages</u>

---

| | | | |
|:---|:---|:---|:---|
| **1** | NAMES OF REPORTING PERSONS<br>Deerfield Mgmt, L.P. | NAMES OF REPORTING PERSONS<br>Deerfield Mgmt, L.P. |  |
| **2** | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP\* | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP\* | (a) ☐<br> (b) ☒ |
| **3** | SEC USE ONLY | SEC USE ONLY |  |
| **4** | SOURCE OF FUNDS<br>WC | SOURCE OF FUNDS<br>WC |  |
| **5** | CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) | CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) | ☒ |
| **6** | CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware | CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **7** | SOLE VOTING POWER<br>0 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **8** | SHARED VOTING POWER<br>2,777,777 (4) |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **9**<br>| SOLE DISPOSITIVE POWER<br>0 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **10**<br>| SHARED DISPOSITIVE POWER<br>2,777,777 (4) |  |
| **11**<br>| AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>2,777,777 (4) | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>2,777,777 (4) |  |
| **12** | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES\* | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES\* | ☐ |
| **13**<br>| PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>6.42% | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>6.42% |  |
| **14** | TYPE OF REPORTING PERSON<br>PN | TYPE OF REPORTING PERSON<br>PN |  |

---

(4) Comprised of shares of common stock held by Deerfield Partners, L.P.,
of which Deerfield Mgmt, L.P. is the general partner.

SCHEDULE 13D

<u>CUSIP No. <u>517125100</u></u> <u>Page 10 of 17 Pages</u>

---

| | | | |
|:---|:---|:---|:---|
| **1** | NAMES OF REPORTING PERSONS<br>Deerfield Management Company, L.P. | NAMES OF REPORTING PERSONS<br>Deerfield Management Company, L.P. |  |
| **2** | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP\* | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP\* | (a) ☐<br> (b) ☒ |
| **3** | SEC USE ONLY | SEC USE ONLY |  |
| **4** | SOURCE OF FUNDS<br>AF | SOURCE OF FUNDS<br>AF |  |
| **5** | CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) | CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) | ☒ |
| **6** | CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware | CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **7** | SOLE VOTING POWER<br>0 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **8** | SHARED VOTING POWER<br>16,973,635 (5) |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **9**<br>| SOLE DISPOSITIVE POWER<br>0 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **10**<br>| SHARED DISPOSITIVE POWER<br>16,973,635 (5) |  |
| **11**<br>| AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>16,973,635 (5) | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>16,973,635 (5) |  |
| **12** | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES\* | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES\* | ☐ |
| **13**<br>| PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>39.20% | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>39.20% |  |
| **14** | TYPE OF REPORTING PERSON<br>PN | TYPE OF REPORTING PERSON<br>PN |  |

---

(5) Comprised of (i) an aggregate of 16,941,357 shares of common stock
held by Deerfield Private Design Fund III, L.P., Deerfield Private Design Fund IV, L.P., Deerfield Healthcare Innovations Fund, L.P.
and Deerfield Partners, L.P., of which Deerfield Management Company, L.P. is the investment manager and (ii) an aggregate of 32,278 shares
of common stock issuable upon exercise of options (the "Leff Options") held by Jonathan Leff, an employee of Deerfield Management
Company, L.P., for the benefit, and subject to the direction, of Deerfield Management Company, L.P. The Leff Options consist of (i) an
option that was granted to Mr. Leff on July 16, 2020 (the "2020 Option") and vests in equal monthly installments over a 36-month
period, which commenced on July 16, 2020, subject to Mr. Leff's continued service with the Issuer through each applicable vesting
date, (ii) an option that was granted to Mr. Leff on May 12, 2021 and is fully vested, and (iii) an option that was granted to Mr. Leff
on May 10, 2022 and will vest within 60 days. The number of shares reported as being beneficially owned by Deerfield Management Company,
L.P. does not include the shares of common stock issuable upon exercise of the 2020 Option to the extent it is unvested and will not
vest within 60 days.

SCHEDULE 13D

<u>CUSIP No. <u>517125100</u></u> <u>Page 11 of 17 Pages</u>

---

| | | | |
|:---|:---|:---|:---|
| **1** | NAMES OF REPORTING PERSONS<br>James E. Flynn | NAMES OF REPORTING PERSONS<br>James E. Flynn |  |
| **2** | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP\* | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP\* | (a) ☐<br> (b) ☒ |
| **3** | SEC USE ONLY | SEC USE ONLY |  |
| **4** | SOURCE OF FUNDS<br>AF | SOURCE OF FUNDS<br>AF |  |
| **5** | CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) | CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) | ☐ |
| **6** | CITIZENSHIP OR PLACE OF ORGANIZATION<br>United States of America | CITIZENSHIP OR PLACE OF ORGANIZATION<br>United States of America |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **7** | SOLE VOTING POWER<br>0 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **8** | SHARED VOTING POWER<br>16,973,635 (6) |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **9**<br>| SOLE DISPOSITIVE POWER<br>0 |  |
| <br>**NUMBER OF**<br> **SHARES BENEFICIALLY OWNED BY**<br> **EACH**<br> **REPORTING**<br> **PERSON**<br> **WITH** | **10**<br>| SHARED DISPOSITIVE POWER<br>16,973,635 (6) |  |
| **11**<br>| AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>16,973,635 (6) | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>16,973,635 (6) |  |
| **12** | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES\* | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES\* | ☐ |
| **13**<br>| PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>39.20% | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>39.20% |  |
| **14** | TYPE OF REPORTING PERSON<br>IN | TYPE OF REPORTING PERSON<br>IN |  |

---

(6) Comprised of (i) an aggregate of 16,973,635 shares of common stock
held by Deerfield Private Design Fund III, L.P., Deerfield Private Design Fund IV, L.P., Deerfield Healthcare Innovations Fund, L.P.
and Deerfield Partners, L.P., of which Deerfield Management Company, L.P. is the investment manager and (ii) an aggregate of 32,278 shares
of common stock issuable upon exercise of options (the "Leff Options") held by Jonathan Leff, an employee of Deerfield Management
Company, L.P., for the benefit, and subject to the direction, of Deerfield Management Company, L.P. The Leff Options consist of (i) an
option that was granted to Mr. Leff on July 16, 2020 (the "2020 Option") and vests in equal monthly installments over a 36-month
period, which commenced on July 16, 2020, subject to Mr. Leff's continued service with the Issuer through each applicable vesting
date, (ii) an option that was granted to Mr. Leff on May 12, 2021 and is fully vested, and (iii) an option that was granted to Mr. Leff
on May 10, 2022 and will vest within 60 days. The number of shares reported as being beneficially owned by Mr. Flynn does not include
the shares of common stock issuable upon exercise of the 2020 Option to the extent it is unvested and will not vest within 60 days. Mr.
Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt IV, L.P., Deerfield Mgmt HIF, L.P.,
Deerfield Mgmt, L.P. and Deerfield Management Company, L.P.

This Amendment No. 6 (this "<u>Amendment</u>") to Schedule 13D is filed by (i) Deerfield Private Design Fund III, L.P. ("<u>Deerfield Private Design Fund III</u>"), (ii) Deerfield Healthcare Innovations Fund, L.P. ("<u>Deerfield Healthcare Innovations Fund</u>"), (iii) Deerfield Private Design Fund IV, L.P. ("<u>Deerfield Private Design Fund IV</u>"), (iv) Deerfield Partners, L.P. ("<u>Deerfield Partners</u>"), (v) Deerfield Mgmt III, L.P. ("<u>Deerfield Mgmt III</u>"), (vi) Deerfield Mgmt HIF, L.P. ("<u>Deerfield Mgmt HIF</u>"), (vii) Deerfield Mgmt IV, L.P. ("<u>Deerfield Mgmt IV</u>"), (viii) Deerfield Mgmt, L.P. ("<u>Deerfield Mgmt</u>"), (ix) Deerfield Management Company, L.P. ("<u>Deerfield Management</u>") and (x) James E. Flynn ("<u>Flynn</u>" and, together with Deerfield Private Design Fund III, Deerfield Healthcare Innovations Fund, Deerfield Private Design Fund IV, Deerfield Partners, Deerfield Mgmt III, Deerfield Mgmt HIF, Deerfield Mgmt IV, Deerfield Mgmt and Deerfield Management, the "<u>Reporting Persons</u>"), with respect to the securities of Larimar Therapeutics, Inc. (as amended by Amendment No.1, Amendment No. 2, Amendment No. 3, Amendment No. 4, Amendment No. 5 and this Amendment No. 6, the "<u>Schedule 13D</u>"). Deerfield Private Design Fund III, Deerfield Healthcare Innovations Fund, Deerfield Private Design Fund IV and Deerfield Partners are collectively referred to herein as the "<u>Funds</u>".

Capitalized terms used herein but not otherwise defined herein shall have the meanings ascribed to them in the Schedule 13D.

**Item 5. Interest in Securities of the Issuer.**

*Items 5(a) and 5(b) of the Schedule 13D are hereby amended and restated in their entirety to read as follows:*

---

| | | | |
|:---|:---|:---|:---|
| (a) |  |  |  |
|  | (1) | <u>Deerfield Private Design Fund III</u> | <u>Deerfield Private Design Fund III</u> |
|  |  | Number of shares: | 4721183 |
|  |  | Percentage of shares: | 10.91%\* |
|  | (2) | <u>Deerfield Healthcare Innovations Fund</u> | <u>Deerfield Healthcare Innovations Fund</u> |
|  |  | Number of shares: | 4721197 |
|  |  | Percentage of shares: | 10.91%\* |
|  | (3) | <u>Deerfield Private Design Fund IV</u> | <u>Deerfield Private Design Fund IV</u> |
|  |  | Number of shares: | 4721200 |
|  |  | Percentage of shares: | 10.91%\* |
|  | (4) | <u>Deerfield Partners</u> |  |
|  |  | Number of shares: | 2777777 |
|  |  | Percentage of shares: | 6.42%\* |
|  | (5) | <u>Deerfield Mgmt III</u> |  |
|  |  | Number of shares: | 4,721,183 (comprised of shares held by Deerfield Private Design Fund III) |
|  |  | Percentage of shares: | 10.91%\* |

---

---

| | | |
|:---|:---|:---|
| (6) | <u>Deerfield Mgmt HIF</u> |  |
|  | Number of shares: | 4,721,197 (comprised of shares held by Deerfield Healthcare Innovations Fund) |
|  | Percentage of shares: | 10.91%\* |
| (7) | <u>Deerfield Mgmt IV</u> |  |
|  | Number of shares: | 4,721,200 (comprised of shares held by Deerfield Private Design Fund) |
|  | Percentage of shares: | 10.91%\* |
| (8) | <u>Deerfield Mgmt</u> |  |
|  | Number of shares: | 2,777,777 (comprised of shares held by Deerfield Partners) |
|  | Percentage of shares: | 6.42%\* |
| (9) | <u>Deerfield Management</u> |  |
|  | Number of shares: | 16,973,635 (comprised of shares held by Deerfield Private Design Fund III, Deerfield Private Design Fund IV, Deerfield Healthcare Innovations Fund, Deerfield Partners and shares underlying options held by Jonathan Leff at the direction and for the benefit of Deerfield Management) |
|  | Percentage of shares: | 39.20%\* |
| (10) | <u>James E. Flynn</u> |  |
|  | Number of shares: | 16,973,635 (comprised of shares held by Deerfield Private Design Fund III, Deerfield Private Design Fund IV, Deerfield Healthcare Innovations Fund, Deerfield Partners and shares underlying options held by Jonathan Leff at the direction and for the benefit of Deerfield Management) |
|  | Percentage of shares: | 39.20%\* |

---

\*Throughout this report, the percentage of outstanding Common Stock beneficially owned by the Reporting Persons reflects 43,269,200 shares of Common Stock outstanding as of March 13, 2023, as set forth in the Annual Report on Form 10-K, filed by the Company with the Securities and Exchange Commission on March 14, 2023.

(b) ---

| | |
|:---|:---|
| (1) | <u>Deerfield Private Design Fund III</u> |
|  | Sole power to vote or direct the vote: 0 |
|  | Shared power to vote or direct the vote: 4,721,183 |
|  | Sole power to dispose or to direct the disposition: 0 |
|  | Shared power to dispose or direct the disposition: 4,721,183 |

---

---

| | |
|:---|:---|
| (2) | <u>Deerfield Healthcare Innovations Fund</u> |
|  | Sole power to vote or direct the vote: 0 |
|  | Shared power to vote or direct the vote: 4,721,197 |
|  | Sole power to dispose or to direct the disposition: 0 |
|  | Shared power to dispose or direct the disposition: 4,721,197 |
| (3) | <u>Deerfield Private Design Fund IV</u> |
|  | Sole power to vote or direct the vote: 0 |
|  | Shared power to vote or direct the vote: 4,721,200 |
|  | Sole power to dispose or to direct the disposition: 0 |
|  | Shared power to dispose or direct the disposition: 4,721,200 |
| (4) | <u>Deerfield Partners</u> |
|  | Sole power to vote or direct the vote: 0 |
|  | Shared power to vote or direct the vote: 2,777,777 |
|  | Sole power to dispose or to direct the disposition: 0 |
|  | Shared power to dispose or direct the disposition: 2,777,777 |
| (5) | <u>Deerfield Mgmt III</u> |
|  | Sole power to vote or direct the vote: 0 |
|  | Shared power to vote or direct the vote: 4,721,183 |
|  | Sole power to dispose or to direct the disposition: 0 |
|  | Shared power to dispose or direct the disposition: 4,721,183 |
| (6) | <u>Deerfield Mgmt HIF</u> |
|  | Sole power to vote or direct the vote: 0 |
|  | Shared power to vote or direct the vote: 4,721,197 |
|  | Sole power to dispose or to direct the disposition: 0 |
|  | Shared power to dispose or direct the disposition: 4,721,197 |
| (7) | <u>Deerfield Mgmt IV</u> |
|  | Sole power to vote or direct the vote: 0 |
|  | Shared power to vote or direct the vote: 4,721,200 |
|  | Sole power to dispose or to direct the disposition: 0 |
|  | Shared power to dispose or direct the disposition: 4,721,200 |
| (8) | <u>Deerfield Mgmt</u> |
|  | Sole power to vote or direct the vote: 0 |
|  | Shared power to vote or direct the vote: 2,777,777 |
|  | Sole power to dispose or to direct the disposition: 0 |
|  | Shared power to dispose or direct the disposition: 2,777,777 |

---

---

| | |
|:---|:---|
| (9) | <u>Deerfield Management</u> |
|  | Sole power to vote or direct the vote: 0 |
|  | Shared power to vote or direct the vote: 16,973,635 |
|  | Sole power to dispose or to direct the disposition: 0 |
|  | Shared power to dispose or direct the disposition: 16,973,635 |
| (10) | <u>James E. Flynn</u> |
|  | Sole power to vote or direct the vote: 0 |
|  | Shared power to vote or direct the vote: 16,973,635 |
|  | Sole power to dispose or to direct the disposition: 0 |
|  | Shared power to dispose or direct the disposition: 16,973,635 |

---

James E. Flynn is the managing member of the general partner of each of Deerfield Mgmt III, Deerfield Mgmt IV, Deerfield Mgmt HIF, Deerfield Mgmt, and Deerfield Management. Deerfield Mgmt III is the general partner of Deerfield Private Design Fund III. Deerfield Mgmt HIF is the general partner of Deerfield Healthcare Innovations Fund. Deerfield Mgmt IV is the general partner of Deerfield Private Design Fund IV. Deerfield Mgmt is the general partner of Deerfield Partners. Deerfield Management is the investment manager of each of Deerfield Private Design Fund III, Deerfield Healthcare Innovations Fund, Deerfield Private Design Fund IV and Deerfield Partners.

SIGNATURE

After reasonable inquiry and to the best of their knowledge and belief, the undersigned certify that the information set forth in this statement is true, complete and correct.

<br> Dated: March 16, 2023

---

| | |
|:---|:---|
| DEERFIELD PRIVATE DESIGN FUND III, L.P. | DEERFIELD PRIVATE DESIGN FUND III, L.P. |
| By: | Deerfield Mgmt III, L.P., General Partner |
| By: | J.E. Flynn Capital III, LLC, General Partner |
| By: | /s/ Jonathan Isler |
| Name: | Jonathan Isler |
| Title: | Attorney-in-Fact |
| DEERFIELD HEALTHCARE INNOVATIONS FUND, L.P. | DEERFIELD HEALTHCARE INNOVATIONS FUND, L.P. |
| By: | Deerfield Mgmt HIF, L.P., General Partner |
| By: | J.E. Flynn Capital HIF, LLC, General Partner |
| By: | /s/ Jonathan Isler |
|  | Jonathan Isler, Attorney-In-Fact |
| DEERFIELD PRIVATE DESIGN FUND IV, L.P. | DEERFIELD PRIVATE DESIGN FUND IV, L.P. |
| By: | Deerfield Mgmt IV, L.P., General Partner |
| By: | J.E. Flynn Capital IV, LLC, General Partner |
| By: | /s/ Jonathan Isler |
| Name: | Jonathan Isler |
| Title: | Attorney-in-Fact |
| DEERFIELD PARTNERS, L.P. | DEERFIELD PARTNERS, L.P. |
| By: | Deerfield Mgmt, L.P., General Partner |
| By: | J.E. Flynn Capital, LLC, General Partner |
| By: | /s/ Jonathan Isler |
| Name: | Jonathan Isler |
| Title: | Attorney-in-Fact |
| DEERFIELD MGMT, L.P. | DEERFIELD MGMT, L.P. |
| By: | J.E. Flynn Capital, LLC, General Partner |
| By: | /s/ Jonathan Isler |
| Name: | Jonathan Isler |
| Title: | Attorney-in-Fact |

---

---

| | |
|:---|:---|
| DEERFIELD MGMT III, L.P. | DEERFIELD MGMT III, L.P. |
| By: | J.E. Flynn Capital III, LLC, General Partner |
| By: | /s/ Jonathan Isler |
| Name: | Jonathan Isler |
| Title: | Attorney-in-Fact |
| DEERFIELD MGMT HIF, L.P. | DEERFIELD MGMT HIF, L.P. |
| By: | J.E. Flynn Capital HIF, LLC, General Partner |
| By: | /s/ Jonathan Isler |
|  | Jonathan Isler, Attorney-in-Fact |
| DEERFIELD MGMT IV, L.P. | DEERFIELD MGMT IV, L.P. |
| By: | J.E. Flynn Capital IV, LLC, General Partner |
| By: | /s/ Jonathan Isler |
| Name: | Jonathan Isler |
| Title: | Attorney-in-Fact |

---

---

| | |
|:---|:---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | DEERFIELD MANAGEMENT COMPANY, L.P. |
| By: | Flynn Management LLC, General Partner |
| By: | /s/ Jonathan Isler |
| Name: | Jonathan Isler |
| Title: | Attorney-in-Fact |
| JAMES E. FLYNN | JAMES E. FLYNN |
| /s/ Jonathan Isler | /s/ Jonathan Isler |
| Jonathan Isler, Attorney-in-Fact | Jonathan Isler, Attorney-in-Fact |

---