# EDGAR Filing Document

**Accession Number:** 0001737287
**File Stem:** 0001628280-26-017307
**Filing Date:** 2026-3
**Character Count:** 24708
**Document Hash:** 17245b6d71d2fd085184bf83a977015e
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001628280-26-017307.hdr.sgml**: 20260312

**ACCESSION NUMBER**: 0001628280-26-017307

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 15

**REFERENCES 429**: 333-277954

**FILED AS OF DATE**: 20260312

**DATE AS OF CHANGE**: 20260312

**EFFECTIVENESS DATE**: 20260312

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Allogene Therapeutics, Inc.
- **CENTRAL INDEX KEY:** 0001737287
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 823562771
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-294252
- **FILM NUMBER:** 26748415

**BUSINESS ADDRESS:**
- **STREET 1:** 210 EAST GRAND AVENUE
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080
- **BUSINESS PHONE:** (650) 457-2700

**MAIL ADDRESS:**
- **STREET 1:** 210 EAST GRAND AVENUE
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080

**As filed with the Securities and Exchange Commission on March 12, 2026** 

**Registration No. 333-**

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**Washington, D.C. 20549**

**_________________________________**

**FORM S-8**

**REGISTRATION STATEMENT** 

***UNDER***

***THE SECURITIES ACT OF 1933***

**________________________________**

**Allogene Therapeutics, Inc.** 

**(Exact name of registrant as specified in its charter)** 

**________________________________**

---

| | |
|:---|:---|
| **Delaware** | **82-3562771** |
| **(State or other jurisdiction of**<br>**incorporation or organization)** | **(I.R.S. Employer**<br>**Identification No.)** |
| **210 East Grand Avenue**<br>**South San Francisco, California** | **94080** |
| **(Address of Principal Executive Offices)** | **(Zip Code)** |

---

**Amended and Restated 2018 Equity Incentive Plan** 

**2018 Employee Stock Purchase Plan** 

**(Full titles of the plans)**

**David Chang, M.D., Ph.D.** 

**President and Chief Executive Officer** 

**Allogene Therapeutics, Inc.** 

**210 East Grand Avenue** 

**South San Francisco, California 94080** 

**(650) 457-2700** 

**(Name, address, including zip code, and telephone number, including area code, of agent for service)** 

***Copies to:***

**Charles J. Bair, Esq.**

**Asa M. Henin Esq.** 

**Cooley LLP** 

**10265 Science Center Drive** 

**San Diego, California 92121** 

**(858) 550-6000** 

**________________________________**

Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer,"

"smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large Accelerated filer | ☐ | Accelerated filer | ☐ |
| Non-accelerated filer | ☒ | Smaller reporting company | ☒ |
| Emerging growth company | ☐ |  | |

---

If an emerging growth company, indicate by check mark if the Registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

        

------

**REGISTRATION OF ADDITIONAL SHARES PURSUANT TO GENERAL INSTRUCTION E**

This Registration Statement is being filed for the purpose of increasing the number of securities of the same class as other securities for which a Registration Statement of the Registrant on Form S-8 relating to the same employee benefit plan is effective.

The Registrant previously registered shares of the Registrant's common stock, par value $0.001 per share ("Common Stock"), for issuance under the 2018 Plan and 2018 ESPP under Registration Statements on Form S-8 filed with the Securities and Exchange Commission (the "Commission") on <u>[October 24, 2018](https://www.sec.gov/Archives/edgar/data/1737287/000119312518306372/d642001ds8.htm)</u> (File No. 333-227965), <u>[March 8, 2019](https://www.sec.gov/Archives/edgar/data/1737287/000119312519069173/d720187ds8.htm)</u> (File No. 333-230164), <u>[February 27, 2020](https://www.sec.gov/Archives/edgar/data/1737287/000173728720000013/allogene-formsx8x02272020.htm)</u> (File No. 333-236701), <u>[February 25, 2021](https://www.sec.gov/Archives/edgar/data/1737287/000173728721000010/allogene-formsx8x20210225.htm)</u> (File No. 333-253530), <u>[February 23, 2022](https://www.sec.gov/Archives/edgar/data/1737287/000173728722000015/allogene-formsx8x20220223.htm)</u> (File No. 333-262923), <u>[February 28, 2023](https://www.sec.gov/Archives/edgar/data/1737287/000173728723000020/allogene-formsx8x20230228.htm)</u> (File No. 333-270098), <u>[March 14, 2024](https://www.sec.gov/Archives/edgar/data/1737287/000119312524068054/d794229ds8.htm)</u> (File No. 333-277954), and <u>[March 13, 2025](https://www.sec.gov/Archives/edgar/data/1737287/000173728725000038/allogene-formsx8x20250313.htm)</u> (File No. 333-285781). Pursuant to General Instruction E to Form S-8, this Registration Statement hereby incorporates by reference the contents of the Registration Statements referenced above.

**PART II**

**ITEM 3. Incorporation of Certain Documents by Reference**

The following documents filed by the Registrant with the Commission are incorporated by reference into this Registration Statement:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)The Registrant's <u>[Annual Report on Form](https://www.sec.gov/ix?doc=/Archives/edgar/data/1737287/000162828026017242/allo-20251231.htm)</u>10-K (the "Form 10-K") for the fiscal year ended December 31, 2025 filed with the Commission on March 12, 2026 (File No. 001-38693).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)The description of the Registrant's Common Stock, which is registered under Section 12 of the Exchange Act of 1934, as amended (the "Exchange Act"), described in <u>[Exhibit 4.3](https://www.sec.gov/Archives/edgar/data/1737287/000173728723000018/allo-20221231xex43.htm)</u> to the Registrant's Annual Report on Form 10-K for the year ended December 31, 2022, filed with the SEC on February 28, 2023, including all amendments or reports filed for the purpose of updating such description.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)All other reports and documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act (other than Current Reports furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits furnished on such form that relate to such items, and other portions of documents that are furnished and not filed or are otherwise not incorporated into registration statements pursuant to the applicable rules promulgated by the Commission) on or after the date of this Registration Statement and prior to the filing of a post-effective amendment to this Registration Statement that indicates that all securities offered have been sold or that deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part of this Registration Statement from the date of the filing of such reports and documents. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently filed document that also is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.

------

---

| | |
|:---|:---|
| **ITEM 8.** | **EXHIBITS.** |

---

---

| | |
|:---|:---|
| **Exhibit**<br>**Number** | **Description** |
| 4.1<sup>(1)</sup> | <u>[Amended and Restated Certificate of Incorporation of the Registrant.](https://www.sec.gov/Archives/edgar/data/1737287/000119312518299356/d622265dex31.htm)</u> |
| 4.2<sup>(2)</sup> | <u>[Certificate of Amendment of Amended and Restated Certificate of Incorporation of the Registrant.](https://www.sec.gov/Archives/edgar/data/1737287/000173728722000039/allo-20220617x8kxexhibit31.htm)</u> |
| 4.3<sup>(3)</sup> | <u>[Amended and Restated Bylaws of the Registrant.](https://www.sec.gov/Archives/edgar/data/1737287/000119312518299356/d622265dex32.htm)</u> |
| 4.4<sup>(4)</sup> | <u>[Form of Common Stock Certificate of the Registrant.](https://www.sec.gov/Archives/edgar/data/1737287/000119312518290441/d548088dex41.htm)</u> |
| 5.1 | <u>[Opinion of Cooley LLP.](exhibit51-formsx8x20260312.htm)</u> |
| 23.1 | <u>[Consent of Independent Registered Public Accounting Firm.](exhibit231-formsx8x20260312.htm)</u> |
| 23.2 | Consent of Cooley LLP. Reference is made to Exhibit <u>[5.1](exhibit51-formsx8x20260312.htm)</u>. |
| 24.1 | <u>[Power of Attorney. Reference is made to the signature page hereto.](#i29d187cc17ec4170b21ee9f61ff0de06_10)</u> |
| 99.1<sup>(5)</sup> | <u>[Allogene Therapeutics, Inc. Amended and Restated 2018 Equity Incentive Plan and Forms of Stock Option Grant Notice, Option Agreement, Notice of Exercise, Restricted Stock Unit Grant Notice and Restricted Stock Unit Award Agreement thereunder.](https://www.sec.gov/Archives/edgar/data/1737287/000119312518306372/d642001dex992.htm)</u> |
| 99.2<sup>(6)</sup> | <u>[Allogene Therapeutics, Inc. 2018 Employee Stock Purchase Plan.](https://www.sec.gov/Archives/edgar/data/1737287/000119312518306372/d642001dex993.htm)</u> |
| 107 | <u>[Filing Fee Table.](exfilingfees.htm)</u> |

---

<sup>(1)</sup>  Previously filed as Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-38693), filed with the Commission on October 15, 2018 and incorporated herein by reference.

<sup>(2)</sup>  Previously filed as Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-38693), filed with the Commission on June 17, 2022 and incorporated herein by reference.

<sup>(3)</sup>  Previously filed as Exhibit 3.2 to the Registrant's Current Report on Form 8-K (File No. 001-38693), filed with the Commission on October 15, 2018 and incorporated herein by reference.

<sup>(4)</sup>  Previously filed as Exhibit 4.1 to the Registrant's Registration Statement on Form S-1 (File No. 333-227333), originally filed with the Commission on September 14, 2018, as amended, and incorporated herein by reference.

<sup>(5)</sup>  Previously filed as Exhibit 99.2 to the Registrant's Registration Statement on Form S-8 (File No. 333-227965), filed with the Commission on October 24, 2018 and incorporated herein by reference.

<sup>(6)</sup>  Previously filed as Exhibit 99.3 to the Registrant's Registration Statement on Form S-8 (File No. 333-227965), filed with the Commission on October 24, 2018 and incorporated herein by reference.

------

**SIGNATURES**

Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of South San Francisco, State of California, on March 12, 2026.

---

| | |
|:---|:---|
| **Allogene Therapeutics, Inc.** | **Allogene Therapeutics, Inc.** |
| By: | &nbsp;&nbsp;&nbsp;&nbsp; /s/ David Chang, M.D., Ph.D. |
|  | David Chang, M.D., Ph.D. |
|  | President, Chief Executive Officer and Member of the Board of Directors |
|  | *(Principal Executive Officer)* |

---

**POWER OF ATTORNEY**

KNOW ALL BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints David Chang, M.D., Ph.D., and Geoffrey Parker, and each of them, as his or her true and lawful attorneys-in-fact and agents, each with the full power of substitution, for him or her and in his or her name, place or stead, in any and all capacities, to sign any and all amendments to this Registration Statement (including post-effective amendments), and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

------

Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

---

| | | |
|:---|:---|:---|
| **Signature** | **Title** | **Date** |
| /s/ David Chang, M.D., Ph.D. | President, Chief Executive Officer <br>and Member of the Board of Directors | March 12, 2026 |
| David Chang, M.D., Ph.D. | (*Principal Executive Officer*) |  |
| /s/ Geoffrey Parker | Chief Financial Officer | March 12, 2026 |
| Geoffrey Parker | (*Principal Financial Officer*) |  |
| /s/ Annie Yoshiyama | Senior Vice President and Corporate Controller | March 12, 2026 |
| Annie Yoshiyama | (*Principal Accounting Officer*) |  |
| /s/ Arie Belldegrun, M.D. | Executive Chair of the Board of Directors | March 12, 2026 |
| Arie Belldegrun, M.D. |  |  |
| /s/ Elizabeth Barrett | Member of the Board of Directors | March 12, 2026 |
| Elizabeth Barrett |  |  |
| /s/ John DeYoung | Member of the Board of Directors | March 12, 2026 |
| John DeYoung |  |  |
| /s/ Franz Humer, Ph.D. | Member of the Board of Directors | March 12, 2026 |
| Franz Humer, Ph.D. |  |  |
| /s/ Joshua Kazam | Member of the Board of Directors | March 12, 2026 |
| Joshua Kazam |  |  |
| /s/ Stephen Mayo, Ph.D. | Member of the Board of Directors | March 12, 2026 |
| Stephen Mayo, Ph.D. |  |  |
| /s/ Deborah Messemer | Member of the Board of Directors | March 12, 2026 |
| Deborah Messemer |  |  |
| /s/ Vicki Sato, Ph.D. | Member of the Board of Directors | March 12, 2026 |
| Vicki Sato, Ph.D. |  |  |
| /s/ Todd Sisitsky | Member of the Board of Directors | March 12, 2026 |
| Todd Sisitsky |  |  |
| /s/ Owen Witte, M.D. | Member of the Board of Directors | March 12, 2026 |
| Owen Witte, M.D. |  |  |

---

## Ex-Filing

?xml version='1.0' encoding='ASCII'? exfilingfees

---

| |
|:---|
| **Calculation of Filing Fee Tables** |
| **S-8** |
| **Allogene Therapeutics, Inc.** |

---

**Table 1: Newly Registered Securities**<br>

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | **Security Type** | **Security Class Title** | **Fee Calculation Rule** | **Amount Registered** | **Proposed Maximum Offering Price Per Unit** | **Maximum Aggregate Offering Price** | **Fee Rate** | **Amount of Registration Fee** |
| 1 | Equity | Amended and Restated 2018 Equity Incentive Plan<br>Common Stock, $0.001 par value per share | Other | 11470676  | $2.26  | $25923728  | 0.0001381 | $3580.07  |
| 2 | Equity | 2018 Employee Stock Purchase Plan<br>Common Stock, $0.001 par value per share | Other | 2294135  | $1.92  | $4404739  | 0.0001381 | $608.29  |
| Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: |  | $30328467  |  | $4188.36  |
| Total Fee Offsets: | Total Fee Offsets: | Total Fee Offsets: | Total Fee Offsets: | Total Fee Offsets: |  |  |  | $—  |
| Net Fee Due: | Net Fee Due: | Net Fee Due: | Net Fee Due: | Net Fee Due: |  |  |  | $4188.36  |

---

**Offering Note**<br>

------

---

| | |
|:---|:---|
| 1 | Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "Securities Act"), the Amount Registered in this Registration Statement on Form S-8 shall also cover any additional shares of the Common Stock ("Common Stock") of Allogene Therapeutics, Inc. (the "Registrant") that become issuable under the Registrant's Amended and Restated 2018 Equity Incentive Plan (the "2018 Plan"), by reason of any stock dividend, stock split, recapitalization or other similar transaction. <br>The Amount Registered represents shares of Common Stock that were automatically added to the shares authorized for issuance under the 2018 Plan on January 1, 2026, pursuant to an evergreen provision contained in the 2018 Plan. Pursuant to such provision, on January 1 of each year through January 1, 2028, the number of shares authorized for issuance under the 2018 Plan is automatically increased by: (a) a number equal to 5% of the total number of shares of Common Stock outstanding on December 31 of the preceding calendar year; or (b) such lesser number of shares of Common Stock as the Registrant's board of directors (the "Board") may designate prior to the applicable January 1st. <br>The Proposed Maximum Offering Price Per Unit and Maximum Aggregate Offering Price estimates are made pursuant to Rule 457(c) and Rule 457(h)(1) of the Securities Act solely for purposes of calculating the registration fee and are based upon the average of the high and low prices of the Common Stock on March 6th, 2026, as reported on the Nasdaq Global Select Market. |
| 2 | Pursuant to Rule 416(a) under the Securities Act, the Amount Registered in this Registration Statement on Form S-8 shall also cover any additional shares of Common Stock of the Registrant that become issuable under the Registrant's 2018 Employee Stock Purchase Plan (the "2018 ESPP"), by reason of any stock dividend, stock split, recapitalization or other similar transaction. <br>The Amount Registered represents shares of Common Stock that were automatically added to the shares authorized for issuance under the 2018 ESPP on January 1, 2026, pursuant to an evergreen provision contained in the 2018 ESPP. Pursuant to such provision, on January 1 of each year through January 1, 2028, the number of shares authorized for issuance under the 2018 ESPP is automatically increased by a number equal to the lesser of: (a) 1% of the total number of shares of Common Stock outstanding on December 31 of the preceding calendar year; (b) 2,320,000 shares; and (c) such lesser number of shares of Common Stock as the Board may designate prior to the applicable January 1st. <br>The Proposed Maximum Offering Price Per Unit and Maximum Aggregate Offering Price estimates are made pursuant to Rule 457(c) and Rule 457(h)(1) of the Securities Act solely for purposes of calculating the registration fee and are based upon the average of the high and low prices of the Common Stock on March 6th, 2026, as reported on the Nasdaq Global Select Market, multiplied by 85%, which is the percentage of the trading price per share applicable to purchasers under the 2018 ESPP. |

---

---

| | |
|:---|:---|
| **Table 2: Fee Offset Claims and Sources** | **☑Not Applicable** |

---

------

---

| | | | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | **Registrant or Filer Name** | **Form or Filing Type** | **File Number** | **Initial Filing Date** | **Filing Date** | **Fee Offset Claimed** | **Security Type Associated with Fee Offset Claimed** | **Security Title Associated with Fee Offset Claimed** | **Unsold Securities Associated with Fee Offset Claimed** | **Unsold Aggregate Offering Amount Associated with Fee Offset Claimed** | **Fee Paid with Fee Offset Source** |
| **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** |
| Fee Offset Claims | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Fee Offset Sources | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |

---

## Exhibit 5.1

**Exhibit 5.1**

![cooleya.jpg](cooleya.jpg)

Asa M. Henin

+1 858 550 6104

ahenin@cooley.com

March 12, 2026

Allogene Therapeutics, Inc.

210 East Grand Avenue

South San Francisco, California 94080

**Re: &nbsp;&nbsp;&nbsp;&nbsp;Registration on Form S-8**

Ladies and Gentlemen:

We have acted as counsel to Allogene Therapeutics, Inc., a Delaware corporation (the "***Company***"), in connection with the filing by the Company of a registration statement on Form S-8 (the "***Registration Statement***") with the Securities and Exchange Commission (the "***Commission***") covering the offering of up to 13,764,811 shares (the "***Shares***") of the Company's common stock, par value $0.001 per share ("***Common Stock***"), consisting of (i) 11,470,676 shares of Common Stock issuable pursuant to the Company's Amended and Restated 2018 Equity Incentive Plan (the "***Incentive Plan***") and (ii) 2,294,135 shares of Common Stock issuable pursuant to the Company's 2018 Employee Stock Purchase Plan (together with the Incentive Plan, the "***Plans***").

In connection with this opinion, we have examined and relied upon (i) the Registration Statement and the related prospectuses, (ii) the Plans, (iii) the Company's certificate of incorporation and bylaws, each as currently in effect, and (iv) such other records, documents, opinions, certificates, memoranda and instruments as in our judgment are necessary or appropriate to enable us to render the opinion expressed below. We have assumed the genuineness of all signatures, the authenticity of all documents submitted to us as originals, the conformity to originals of all documents submitted to us as copies, the accuracy, completeness and authenticity of certificates of public officials, and the due authorization, execution and delivery of all documents by all persons other than the Company. As to certain factual matters, we have relied upon a certificate of an officer of the Company and have not independently verified such matters.

Our opinion is expressed only with respect to the General Corporation Law of the State of Delaware. We express no opinion to the extent that any other laws are applicable to the subject matter hereof and express no opinion and provide no assurance as to compliance with any federal or state securities law, rule or regulation.

On the basis of the foregoing, and in reliance thereon, we are of the opinion that the Shares, when sold and issued in accordance with the Plans, the Registration Statement and the related prospectuses, will be validly issued, fully paid and nonassessable (except as to Shares issued pursuant to deferred payment arrangements, which will be fully paid and nonassessable when such deferred payments are made in full).

Cooley LLP 10265 Science Center Drive San Diego, CA 92121-1117

t: +1 858 550 6000 f: +1 858 550-6420 cooley.com

------

![cooleya.jpg](cooleya.jpg)

Allogene Therapeutics, Inc.

March 12, 2026

Page Two

This opinion is limited to the matters expressly set forth in this letter, and no opinion has been or should be implied, or may be inferred, beyond the matters expressly stated. This opinion speaks only as to law and facts in effect or existing as of the date hereof, and we have no obligation or responsibility to update or supplement this opinion to reflect any facts or circumstances that may hereafter come to our attention or any changes in law that may hereafter occur.

We consent to the filing of this opinion as an exhibit to the Registration Statement. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act of 1933, as amended, or the rules and regulations of the Commission thereunder.

Sincerely,

Cooley LLP

By: <u>/s/ Asa M. Henin</u> 

Asa M. Henin

Cooley LLP 10265 Science Center Drive San Diego, CA 92121-1117

t: +1 858 550 6000 f: +1 858 550-6420 cooley.com

## Exhibit 23.1

**Exhibit 23.1**

**Consent of Independent Registered Public Accounting Firm**

We consent to the incorporation by reference in the Registration Statement (Form S-8) pertaining to the Amended and Restated 2018 Equity Incentive Plan and 2018 Employee Stock Purchase Plan of Allogene Therapeutics, Inc. of our report dated March 12, 2026, with respect to the consolidated financial statements of Allogene Therapeutics, Inc. included in its Annual Report (Form 10-K) for the year ended December 31, 2025, filed with the Securities and Exchange Commission.

/s/ Ernst & Young LLP

San Mateo, California

March 12, 2026

<br>