# EDGAR Filing Document

**Accession Number:** 0001174610
**File Stem:** 0002071691-25-004025
**Filing Date:** 2025-10
**Character Count:** 96499
**Document Hash:** 1bbf8759a1b5231498b4b2c1609a2e1e
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0002071691-25-004025.hdr.sgml**: 20251029

**ACCESSION NUMBER**: 0002071691-25-004025

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20250831

**FILED AS OF DATE**: 20251029

**DATE AS OF CHANGE**: 20251029

**PERIOD START**: 20260531

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** PROSHARES TRUST
- **CENTRAL INDEX KEY:** 0001174610

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 0531

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-21114
- **FILM NUMBER:** 251427581

**BUSINESS ADDRESS:**
- **STREET 1:** 7272 WISCONSIN AVENUE
- **STREET 2:** 21ST FLOOR
- **CITY:** BETHESDA
- **STATE:** MD
- **ZIP:** 20814
- **BUSINESS PHONE:** 240-497-6400

**MAIL ADDRESS:**
- **STREET 1:** 7272 WISCONSIN AVENUE
- **STREET 2:** 21ST FLOOR
- **CITY:** BETHESDA
- **STATE:** MD
- **ZIP:** 20814

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** XTRASHARES TRUST
- **DATE OF NAME CHANGE:** 20030409

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** PROFUNDS ETF TRUST
- **DATE OF NAME CHANGE:** 20020531

## Series and Classes Contracts Data

### ProShares Ultra Nasdaq Biotechnology (Series ID: S000018718)

| Class ID   | Class Name                           | Ticker Symbol   |
|:---|:---|:---|
| C000051848 | ProShares Ultra Nasdaq Biotechnology | BIB             |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** ProShares Trust

- **b. Investment Company Act file number:** 811-21114

- **c. CIK number of Registrant:** 0001174610

- **d. LEI of Registrant:** 5493005D9DS7C1P5AM59

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 7272 Wisconsin Avenue

  - **City:** Bethesda

  - **State:** MD

  - **Foreign country:** US

  - **Zip / Postal Code:** 20814

  - **Telephone number:** 240-497-6400

**Item A.2. Information about the Series.**

- **a. Name of Series:** ProShares Ultra Nasdaq Biotechnology

- **b. EDGAR series identifier (if any):** S000018718

- **c. LEI of Series:** SL5GC2XPBUL7EXVSNF27

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2026-05-31

- **b. Date as of which information is reported:** 2025-08-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $59372386.46

**Total Liabilities:** $5781024.70

**Net Assets:** $53591361.76

**Cash Not Reported:** $9641162.28

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000051848 | 6.82%                | 10.39%               | 9.35%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $135897.10               | $1055320.70                                |
| Month 2  | $-34425.37               | $1877997.82                                |
| Month 3  | $229124.17               | $1488718.88                                |

**Designated Index Information**

- **Index Name:** Nasdaq Biotechnology Index

- **Index Identifier:** NBI

### Schedule of Portfolio Investments

| Name                                      | Title                                                   | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Applied Therapeutics, Inc.                | Applied Therapeutics, Inc.                              | CUSIP: 03828A101<br>LEI: 549300KL3IJPHZM2GR04 | Long             | EC               | CORP              | US        |      4977 | NS      | $2452.17      | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| MannKind Corp.                            | MannKind Corp.                                          | CUSIP: 56400P706<br>LEI: 213800GFBCNY1ZFST722 | Long             | EC               | CORP              | US        |     10683 | NS      | $49034.97     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurogene, Inc.                           | Neurogene, Inc.                                         | CUSIP: 64135M105<br>LEI: 529900A7VIY892SZVW73 | Long             | EC               | CORP              | US        |       502 | NS      | $9276.96      | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Apogee Therapeutics, Inc.                 | Apogee Therapeutics, Inc.                               | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1616 | NS      | $58773.92     | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Enliven Therapeutics, Inc.                | Enliven Therapeutics, Inc.                              | CUSIP: 29337E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1724 | NS      | $34945.48     | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Bicycle Therapeutics plc                  | Bicycle Therapeutics plc                                | CUSIP: 088786108<br>LEI: 213800XKUI6R7GKC3E43 | Long             | EC               | CORP              | GB        |      1551 | NS      | $11446.38     | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Ionis Pharmaceuticals, Inc.               | Ionis Pharmaceuticals, Inc.                             | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |      5595 | NS      | $238542.83    | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| United Therapeutics Corp.                 | United Therapeutics Corp.                               | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |      1584 | NS      | $482739.84    | 0.90%             |  |  |  | No            |                  1 | On Loan: No      |
| Solid Biosciences, Inc.                   | Solid Biosciences, Inc.                                 | CUSIP: 83422E204<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2724 | NS      | $14927.52     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| uniQure NV                                | uniQure NV                                              | CUSIP: N/A<br>LEI: 724500RPCTZLFYJZ3S98       | Long             | EC               | CORP              | NL        |      1924 | NS      | $31418.92     | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| ORIC Pharmaceuticals, Inc.                | ORIC Pharmaceuticals, Inc.                              | CUSIP: 68622P109<br>LEI: 54930033FJRNEYBW0L25 | Long             | EC               | CORP              | US        |      2500 | NS      | $25575.00     | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Tango Therapeutics, Inc.                  | Tango Therapeutics, Inc.                                | CUSIP: 87583X109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3811 | NS      | $25571.81     | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Madrigal Pharmaceuticals, Inc.            | Madrigal Pharmaceuticals, Inc.                          | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |       779 | NS      | $341085.15    | 0.64%             |  |  |  | No            |                  1 | On Loan: No      |
| 4D Molecular Therapeutics, Inc.           | 4D Molecular Therapeutics, Inc.                         | CUSIP: 35104E100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1629 | NS      | $10034.64     | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Savara, Inc.                              | Savara, Inc.                                            | CUSIP: 805111101<br>LEI: 5493002JO0WM3YMJXG33 | Long             | EC               | CORP              | US        |      6074 | NS      | $19922.72     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Ligand Pharmaceuticals, Inc.              | Ligand Pharmaceuticals, Inc.                            | CUSIP: 53220K504<br>LEI: 5493008K7TB0IKP37H79 | Long             | EC               | CORP              | US        |       678 | NS      | $109639.38    | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Stoke Therapeutics, Inc.                  | Stoke Therapeutics, Inc.                                | CUSIP: 86150R107<br>LEI: 549300RD25SS2DIJHJ67 | Long             | EC               | CORP              | US        |      1919 | NS      | $37919.44     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| BioMarin Pharmaceutical, Inc.             | BioMarin Pharmaceutical, Inc.                           | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |      6739 | NS      | $392681.53    | 0.73%             |  |  |  | No            |                  1 | On Loan: No      |
| Lexeo Therapeutics, Inc.                  | Lexeo Therapeutics, Inc.                                | CUSIP: 52886X107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1166 | NS      | $5585.14      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                       | Total Return Swap                                       | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |      1895 | NC      | $-1112110.56  | -2.08%            |  |  |  | No            |                  2 | On Loan: No      |
| Kymera Therapeutics, Inc.                 | Kymera Therapeutics, Inc.                               | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2288 | NS      | $94265.60     | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Alumis, Inc.                              | Alumis, Inc.                                            | CUSIP: 022307102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3360 | NS      | $15590.40     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Merus NV                                  | Merus NV                                                | CUSIP: N/A<br>LEI: 549300W8GPUWU8QNU293       | Long             | EC               | CORP              | NL        |      2434 | NS      | $160254.56    | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Jazz Pharmaceuticals plc                  | Jazz Pharmaceuticals plc                                | CUSIP: N/A<br>LEI: 635400GAUMJCLEZRRV50       | Long             | EC               | CORP              | IE        |      2167 | NS      | $276834.25    | 0.52%             |  |  |  | No            |                  1 | On Loan: No      |
| 89bio, Inc.                               | 89bio, Inc.                                             | CUSIP: 282559103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5130 | NS      | $46323.90     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Amylyx Pharmaceuticals, Inc.              | Amylyx Pharmaceuticals, Inc.                            | CUSIP: 03237H101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3135 | NS      | $29406.30     | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Mineralys Therapeutics, Inc.              | Mineralys Therapeutics, Inc.                            | CUSIP: 603170101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2290 | NS      | $35449.20     | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Medpace Holdings, Inc.                    | Medpace Holdings, Inc.                                  | CUSIP: 58506Q109<br>LEI: 549300H8TYEUVTW14A54 | Long             | EC               | CORP              | US        |      1011 | NS      | $480740.61    | 0.90%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences, Inc.              | Neurocrine Biosciences, Inc.                            | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |      3479 | NS      | $485668.40    | 0.91%             |  |  |  | No            |                  1 | On Loan: No      |
| MeiraGTx Holdings plc                     | MeiraGTx Holdings plc                                   | CUSIP: N/A<br>LEI: 54930007YV6NYIOGFZ57       | Long             | EC               | CORP              | KY        |      2823 | NS      | $20607.90     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Absci Corp.                               | Absci Corp.                                             | CUSIP: 00091E109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4484 | NS      | $10716.76     | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Insmed, Inc.                              | Insmed, Inc.                                            | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |      6403 | NS      | $871448.30    | 1.63%             |  |  |  | No            |                  1 | On Loan: No      |
| Dyne Therapeutics, Inc.                   | Dyne Therapeutics, Inc.                                 | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3997 | NS      | $53919.53     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Vera Therapeutics, Inc.                   | Vera Therapeutics, Inc., Class A                        | CUSIP: 92337R101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2242 | NS      | $48516.88     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Rhythm Pharmaceuticals, Inc.              | Rhythm Pharmaceuticals, Inc.                            | CUSIP: 76243J105<br>LEI: 529900JPNWXQ8DPLA551 | Long             | EC               | CORP              | US        |      2236 | NS      | $230643.40    | 0.43%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen, Inc.                              | Biogen, Inc.                                            | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |      5150 | NS      | $680933.00    | 1.27%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                       | Total Return Swap                                       | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |      2893 | NC      | $767260.25    | 1.43%             |  |  |  | No            |                  2 | On Loan: No      |
| Design Therapeutics, Inc.                 | Design Therapeutics, Inc.                               | CUSIP: 25056L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1996 | NS      | $11037.88     | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Kura Oncology, Inc.                       | Kura Oncology, Inc.                                     | CUSIP: 50127T109<br>LEI: 5493005QORQTZCZYOP39 | Long             | EC               | CORP              | US        |      3043 | NS      | $24039.70     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Tarsus Pharmaceuticals, Inc.              | Tarsus Pharmaceuticals, Inc.                            | CUSIP: 87650L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1476 | NS      | $86464.08     | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Nurix Therapeutics, Inc.                  | Nurix Therapeutics, Inc.                                | CUSIP: 67080M103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2680 | NS      | $25031.20     | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Pliant Therapeutics, Inc.                 | Pliant Therapeutics, Inc.                               | CUSIP: 729139105<br>LEI: 5493002Q5LITR7VHZH02 | Long             | EC               | CORP              | US        |      2157 | NS      | $3537.48      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Royalty Pharma plc                        | Royalty Pharma plc, Class A                             | CUSIP: N/A<br>LEI: 549300FGFN7VOK8BZR03       | Long             | EC               | CORP              | GB        |     14809 | NS      | $532827.82    | 0.99%             |  |  |  | No            |                  1 | On Loan: No      |
| Phathom Pharmaceuticals, Inc.             | Phathom Pharmaceuticals, Inc.                           | CUSIP: 71722W107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2452 | NS      | $29865.36     | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| HUTCHMED China Ltd.                       | HUTCHMED China Ltd.                                     | CUSIP: 44842L103<br>LEI: 2138006X34YDQ6OBYE79 | Long             | EC               | CORP              | KY        |      1088 | NS      | $16330.88     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Mersana Therapeutics, Inc.                | Mersana Therapeutics, Inc.                              | CUSIP: 59045L205<br>LEI: 529900VWD5VDZ7PVOS22 | Long             | EC               | CORP              | US        |       175 | NS      | $1281.00      | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Entrada Therapeutics, Inc.                | Entrada Therapeutics, Inc.                              | CUSIP: 29384C108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1334 | NS      | $7296.98      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Alpha Teknova, Inc.                       | Alpha Teknova, Inc.                                     | CUSIP: 02080L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1879 | NS      | $8117.28      | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Phibro Animal Health Corp.                | Phibro Animal Health Corp., Class A                     | CUSIP: 71742Q106<br>LEI: 549300U24SP4AF2JUX52 | Long             | EC               | CORP              | US        |       714 | NS      | $26467.98     | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Editas Medicine, Inc.                     | Editas Medicine, Inc.                                   | CUSIP: 28106W103<br>LEI: 5299000AON4Q9NT2JE42 | Long             | EC               | CORP              | US        |      2944 | NS      | $7566.08      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Ironwood Pharmaceuticals, Inc.            | Ironwood Pharmaceuticals, Inc., Class A                 | CUSIP: 46333X108<br>LEI: 549300PC8MR6QHH6P296 | Long             | EC               | CORP              | US        |      5686 | NS      | $7505.52      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Allogene Therapeutics, Inc.               | Allogene Therapeutics, Inc.                             | CUSIP: 019770106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7688 | NS      | $8687.44      | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Edgewise Therapeutics, Inc.               | Edgewise Therapeutics, Inc.                             | CUSIP: 28036F105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3694 | NS      | $53008.90     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Argenx SE                                 | Argenx SE                                               | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |      1108 | NS      | $789117.60    | 1.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Aura Biosciences, Inc.                    | Aura Biosciences, Inc.                                  | CUSIP: 05153U107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2180 | NS      | $13646.80     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Genmab A/S                                | Genmab A/S                                              | CUSIP: 372303206<br>LEI: 529900MTJPDPE4MHJ122 | Long             | EC               | CORP              | DK        |      1473 | NS      | $36633.51     | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Recursion Pharmaceuticals, Inc.           | Recursion Pharmaceuticals, Inc., Class A                | CUSIP: 75629V104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     14049 | NS      | $66030.30     | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Esperion Therapeutics, Inc.               | Esperion Therapeutics, Inc.                             | CUSIP: 29664W105<br>LEI: 549300OFU56UKEWVUS92 | Long             | EC               | CORP              | US        |      6967 | NS      | $15466.74     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Zai Lab Ltd.                              | Zai Lab Ltd.                                            | CUSIP: 98887Q104<br>LEI: 549300P2UYQ9U5LY1T58 | Long             | EC               | CORP              | KY        |      2034 | NS      | $67325.40     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Olema Pharmaceuticals, Inc.               | Olema Pharmaceuticals, Inc.                             | CUSIP: 68062P106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2404 | NS      | $13125.84     | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Revolution Medicines, Inc.                | Revolution Medicines, Inc.                              | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |      6545 | NS      | $248513.65    | 0.46%             |  |  |  | No            |                  1 | On Loan: No      |
| MacroGenics, Inc.                         | MacroGenics, Inc.                                       | CUSIP: 556099109<br>LEI: 5493001KJQUA83L8MH79 | Long             | EC               | CORP              | US        |      2216 | NS      | $3922.32      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| 10X Genomics, Inc.                        | 10X Genomics, Inc., Class A                             | CUSIP: 88025U109<br>LEI: 5493003Z6741WNLG7H43 | Long             | EC               | CORP              | US        |      3904 | NS      | $54695.04     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Disc Medicine, Inc.                       | Disc Medicine, Inc.                                     | CUSIP: 254604101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1216 | NS      | $72528.32     | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Theravance Biopharma, Inc.                | Theravance Biopharma, Inc.                              | CUSIP: N/A<br>LEI: 5493007VTSXP4Z6MIW52       | Long             | EC               | CORP              | KY        |      1759 | NS      | $24414.92     | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Indivior plc                              | Indivior plc                                            | CUSIP: N/A<br>LEI: 213800V3NCQTY7IED471       | Long             | EC               | CORP              | GB        |      4384 | NS      | $106443.52    | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Tempus AI, Inc.                           | Tempus AI, Inc., Class A                                | CUSIP: 88023B103<br>LEI: 2549009LA0KWRAGQBX50 | Long             | EC               | CORP              | US        |      5908 | NS      | $448180.88    | 0.84%             |  |  |  | No            |                  1 | On Loan: —       |
| Fortrea Holdings, Inc.                    | Fortrea Holdings, Inc.                                  | CUSIP: 34965K107<br>LEI: 5493000FIVFABOVCDU97 | Long             | EC               | CORP              | US        |      3182 | NS      | $31342.70     | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| WaVe Life Sciences Ltd.                   | WaVe Life Sciences Ltd.                                 | CUSIP: N/A<br>LEI: 54930070006GPKFYZ813       | Long             | EC               | CORP              | SG        |      5419 | NS      | $52022.40     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Q32 Bio, Inc.                             | Q32 Bio, Inc.                                           | CUSIP: 746964105<br>LEI: 549300RWKPJEFTM3K452 | Long             | EC               | CORP              | US        |       428 | NS      | $731.88       | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                       | Total Return Swap                                       | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |      1924 | NC      | $328084.59    | 0.61%             |  |  |  | No            |                  2 | On Loan: No      |
| Ideaya Biosciences, Inc.                  | Ideaya Biosciences, Inc.                                | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |      3077 | NS      | $75540.35     | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Roivant Sciences Ltd.                     | Roivant Sciences Ltd.                                   | CUSIP: N/A<br>LEI: 549300DL466NY5J6U724       | Long             | EC               | CORP              | BM        |     23894 | NS      | $285055.42    | 0.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Praxis Precision Medicines, Inc.          | Praxis Precision Medicines, Inc.                        | CUSIP: 74006W207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       714 | NS      | $32515.56     | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Twist Bioscience Corp.                    | Twist Bioscience Corp.                                  | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |      2106 | NS      | $56798.82     | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytokinetics, Inc.                        | Cytokinetics, Inc.                                      | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |      4196 | NS      | $148244.68    | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| OmniAb, Inc.                              | OmniAb, Inc.                                            | CUSIP: 68218J103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4301 | NS      | $6881.60      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Sutro Biopharma, Inc.                     | Sutro Biopharma, Inc.                                   | CUSIP: 869367102<br>LEI: 5493005U6P15VD25P851 | Long             | EC               | CORP              | US        |      2968 | NS      | $2543.87      | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcturus Therapeutics Holdings, Inc.      | Arcturus Therapeutics Holdings, Inc.                    | CUSIP: 03969T109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       955 | NS      | $16244.55     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Illumina, Inc.                            | Illumina, Inc.                                          | CUSIP: 452327109<br>LEI: SQ95QG8SR5Q56LSNF682 | Long             | EC               | CORP              | US        |      5563 | NS      | $556077.48    | 1.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Exelixis, Inc.                            | Exelixis, Inc.                                          | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |      9584 | NS      | $358633.28    | 0.67%             |  |  |  | No            |                  1 | On Loan: No      |
| Prothena Corp. plc                        | Prothena Corp. plc                                      | CUSIP: N/A<br>LEI: 5299009ZXQ8NIIJ8OL30       | Long             | EC               | CORP              | IE        |      1894 | NS      | $15530.80     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Fate Therapeutics, Inc.                   | Fate Therapeutics, Inc.                                 | CUSIP: 31189P102<br>LEI: 549300L14Q4UHOODLA90 | Long             | EC               | CORP              | US        |      4029 | NS      | $4190.16      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Day One Biopharmaceuticals, Inc.          | Day One Biopharmaceuticals, Inc.                        | CUSIP: 23954D109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3564 | NS      | $26765.64     | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Galapagos NV                              | Galapagos NV                                            | CUSIP: 36315X101<br>LEI: 549300QKJ78IY0IOV655 | Long             | EC               | CORP              | BE        |       522 | NS      | $16411.68     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Replimune Group, Inc.                     | Replimune Group, Inc.                                   | CUSIP: 76029N106<br>LEI: 549300AY704NEIRC4K64 | Long             | EC               | CORP              | US        |      2708 | NS      | $14623.20     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Janux Therapeutics, Inc.                  | Janux Therapeutics, Inc.                                | CUSIP: 47103J105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2078 | NS      | $47212.16     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Centessa Pharmaceuticals plc              | Centessa Pharmaceuticals plc                            | CUSIP: 152309100<br>LEI: 213800GIDAARDSKOI827 | Long             | EC               | CORP              | GB        |      3357 | NS      | $56364.03     | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Novocure Ltd.                             | Novocure Ltd.                                           | CUSIP: N/A<br>LEI: 213800YPP55UMHWA4826       | Long             | EC               | CORP              | JE        |      3919 | NS      | $48321.27     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Castle Biosciences, Inc.                  | Castle Biosciences, Inc.                                | CUSIP: 14843C105<br>LEI: 2549007M2Q4HLR1XD252 | Long             | EC               | CORP              | US        |      1016 | NS      | $24394.16     | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Xenon Pharmaceuticals, Inc.               | Xenon Pharmaceuticals, Inc.                             | CUSIP: 98420N105<br>LEI: 549300XV44Q9Z1MIPQ03 | Long             | EC               | CORP              | CA        |      2699 | NS      | $104478.29    | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Enanta Pharmaceuticals, Inc.              | Enanta Pharmaceuticals, Inc.                            | CUSIP: 29251M106<br>LEI: 529900SSN4DODDQSN594 | Long             | EC               | CORP              | US        |       752 | NS      | $6316.80      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Amicus Therapeutics, Inc.                 | Amicus Therapeutics, Inc.                               | CUSIP: 03152W109<br>LEI: 549300MRD1SMUTNBPQ53 | Long             | EC               | CORP              | US        |     10825 | NS      | $82161.75     | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Cullinan Therapeutics, Inc.               | Cullinan Therapeutics, Inc.                             | CUSIP: 230031106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2079 | NS      | $15675.66     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC Therapeutics, Inc.                    | PTC Therapeutics, Inc.                                  | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |      2785 | NS      | $137384.05    | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Ultragenyx Pharmaceutical, Inc.           | Ultragenyx Pharmaceutical, Inc.                         | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |      3321 | NS      | $99497.16     | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvalent, Inc.                            | Nuvalent, Inc., Class A                                 | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2331 | NS      | $178507.98    | 0.33%             |  |  |  | No            |                  1 | On Loan: No      |
| Astria Therapeutics, Inc.                 | Astria Therapeutics, Inc.                               | CUSIP: 04635X102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1983 | NS      | $12254.94     | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Codexis, Inc.                             | Codexis, Inc.                                           | CUSIP: 192005106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2912 | NS      | $7949.76      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| ArriVent Biopharma, Inc.                  | ArriVent Biopharma, Inc.                                | CUSIP: 04272N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1204 | NS      | $23020.48     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| UroGen Pharma Ltd.                        | UroGen Pharma Ltd.                                      | CUSIP: N/A<br>LEI: 549300C0YCX7CG2G5D50       | Long             | EC               | CORP              | IL        |      1621 | NS      | $31528.45     | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Mirum Pharmaceuticals, Inc.               | Mirum Pharmaceuticals, Inc.                             | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |      1741 | NS      | $128607.67    | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Kyverna Therapeutics, Inc.                | Kyverna Therapeutics, Inc.                              | CUSIP: 501976104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1521 | NS      | $5642.91      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Lexicon Pharmaceuticals, Inc.             | Lexicon Pharmaceuticals, Inc.                           | CUSIP: 528872302<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     12764 | NS      | $14040.40     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Pacira BioSciences, Inc.                  | Pacira BioSciences, Inc.                                | CUSIP: 695127100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1628 | NS      | $43418.76     | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Pacific Biosciences of California, Inc.   | Pacific Biosciences of California, Inc.                 | CUSIP: 69404D108<br>LEI: 529900F1BWRE1M0KZN89 | Long             | EC               | CORP              | US        |     10547 | NS      | $13816.57     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| AstraZeneca plc                           | AstraZeneca plc                                         | CUSIP: 046353108<br>LEI: PY6ZZQWO2IZFZC3IOL08 | Long             | EC               | CORP              | GB        |     20758 | NS      | $1658564.20   | 3.09%             |  |  |  | No            |                  1 | On Loan: No      |
| MaxCyte, Inc.                             | MaxCyte, Inc.                                           | CUSIP: 57777K106<br>LEI: 54930053YHXULRFCU991 | Long             | EC               | CORP              | US        |      3738 | NS      | $5195.82      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Xencor, Inc.                              | Xencor, Inc.                                            | CUSIP: 98401F105<br>LEI: 549300V5IF65437JKG30 | Long             | EC               | CORP              | US        |      2503 | NS      | $20349.39     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Sarepta Therapeutics, Inc.                | Sarepta Therapeutics, Inc.                              | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |      3453 | NS      | $62844.60     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcutis Biotherapeutics, Inc.             | Arcutis Biotherapeutics, Inc.                           | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4188 | NS      | $64997.76     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Summit Therapeutics, Inc.                 | Summit Therapeutics, Inc.                               | CUSIP: 86627T108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     26102 | NS      | $618617.40    | 1.15%             |  |  |  | No            |                  1 | On Loan: —       |
| Corvus Pharmaceuticals, Inc.              | Corvus Pharmaceuticals, Inc.                            | CUSIP: 221015100<br>LEI: 549300I3AVJ8F75NCX65 | Long             | EC               | CORP              | US        |      2709 | NS      | $15549.66     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Atea Pharmaceuticals, Inc.                | Atea Pharmaceuticals, Inc.                              | CUSIP: 04683R106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3010 | NS      | $10113.60     | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Collegium Pharmaceutical, Inc.            | Collegium Pharmaceutical, Inc.                          | CUSIP: 19459J104<br>LEI: 54930049FXZMTLW8D496 | Long             | EC               | CORP              | US        |      1131 | NS      | $43882.80     | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Evolus, Inc.                              | Evolus, Inc.                                            | CUSIP: 30052C107<br>LEI: 549300VYQRYBQOT8V419 | Long             | EC               | CORP              | US        |      2264 | NS      | $17274.32     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| CG oncology, Inc.                         | CG oncology, Inc.                                       | CUSIP: 156944100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2680 | NS      | $71877.60     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Iovance Biotherapeutics, Inc.             | Iovance Biotherapeutics, Inc.                           | CUSIP: 462260100<br>LEI: 2549002L8WT2ACU5Q878 | Long             | EC               | CORP              | US        |     11738 | NS      | $26175.74     | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Biomea Fusion, Inc.                       | Biomea Fusion, Inc.                                     | CUSIP: 09077A106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1322 | NS      | $2577.90      | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Annexon, Inc.                             | Annexon, Inc.                                           | CUSIP: 03589W102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3857 | NS      | $7945.42      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Syndax Pharmaceuticals, Inc.              | Syndax Pharmaceuticals, Inc.                            | CUSIP: 87164F105<br>LEI: 529900OF94TRHKZVBS87 | Long             | EC               | CORP              | US        |      3023 | NS      | $49365.59     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals, Inc.             | Alnylam Pharmaceuticals, Inc.                           | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |      3994 | NS      | $1783360.94   | 3.33%             |  |  |  | No            |                  1 | On Loan: No      |
| Inhibrx Biosciences, Inc.                 | Inhibrx Biosciences, Inc.                               | CUSIP: 45720N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       510 | NS      | $14382.00     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Vaxcyte, Inc.                             | Vaxcyte, Inc.                                           | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |      4535 | NS      | $139632.65    | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Keros Therapeutics, Inc.                  | Keros Therapeutics, Inc.                                | CUSIP: 492327101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1428 | NS      | $21719.88     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Ascendis Pharma A/S                       | Ascendis Pharma A/S                                     | CUSIP: 04351P101<br>LEI: 549300B66JN3W3J8GH73 | Long             | EC               | CORP              | DK        |      2134 | NS      | $414572.18    | 0.77%             |  |  |  | No            |                  1 | On Loan: No      |
| Novavax, Inc.                             | Novavax, Inc.                                           | CUSIP: 670002401<br>LEI: 529900J4GJHPEPQ23205 | Long             | EC               | CORP              | US        |      5692 | NS      | $42519.24     | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Beam Therapeutics, Inc.                   | Beam Therapeutics, Inc.                                 | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3536 | NS      | $57848.96     | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Oruka Therapeutics, Inc.                  | Oruka Therapeutics, Inc.                                | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |      1317 | NS      | $19491.60     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Taysha Gene Therapies, Inc.               | Taysha Gene Therapies, Inc.                             | CUSIP: 877619106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      9175 | NS      | $26791.00     | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Agios Pharmaceuticals, Inc.               | Agios Pharmaceuticals, Inc.                             | CUSIP: 00847X104<br>LEI: 529900ONJHY8EOGYT555 | Long             | EC               | CORP              | US        |      2035 | NS      | $76739.85     | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Amarin Corp. plc                          | Amarin Corp. plc                                        | CUSIP: 023111404<br>LEI: 5493009JFIGUFEVPK217 | Long             | EC               | CORP              | GB        |       705 | NS      | $10603.20     | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Verona Pharma plc                         | Verona Pharma plc                                       | CUSIP: 925050106<br>LEI: 213800EVI6O6J3TIAL06 | Long             | EC               | CORP              | GB        |      2763 | NS      | $292629.33    | 0.55%             |  |  |  | No            |                  1 | On Loan: No      |
| Axsome Therapeutics, Inc.                 | Axsome Therapeutics, Inc.                               | CUSIP: 05464T104<br>LEI: 549300EXGR0XLRJEIB95 | Long             | EC               | CORP              | US        |      1730 | NS      | $209814.40    | 0.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Humacyte, Inc.                            | Humacyte, Inc.                                          | CUSIP: 44486Q103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5452 | NS      | $8450.60      | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Ardelyx, Inc.                             | Ardelyx, Inc.                                           | CUSIP: 039697107<br>LEI: 549300F542QR4SXHCY32 | Long             | EC               | CORP              | US        |      8407 | NS      | $53468.52     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| ADMA Biologics, Inc.                      | ADMA Biologics, Inc.                                    | CUSIP: 000899104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8392 | NS      | $144845.92    | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| Amneal Pharmaceuticals, Inc.              | Amneal Pharmaceuticals, Inc.                            | CUSIP: 03168L105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     11014 | NS      | $105293.84    | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Alvotech SA                               | Alvotech SA                                             | CUSIP: N/A<br>LEI: 222100DCZBOWV5DZ8372       | Long             | EC               | CORP              | LU        |      9379 | NS      | $75688.53     | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| Newamsterdam Pharma Co. NV                | Newamsterdam Pharma Co. NV                              | CUSIP: N/A<br>LEI: 984500B6549TF6E14D36       | Long             | EC               | CORP              | NL        |      3944 | NS      | $94853.20     | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Crinetics Pharmaceuticals, Inc.           | Crinetics Pharmaceuticals, Inc.                         | CUSIP: 22663K107<br>LEI: 549300Q1CNFXK5P31D28 | Long             | EC               | CORP              | US        |      3293 | NS      | $102050.07    | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Alector, Inc.                             | Alector, Inc.                                           | CUSIP: 014442107<br>LEI: 549300Z8RQOIY1JMHC25 | Long             | EC               | CORP              | US        |      3513 | NS      | $8255.55      | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| AnaptysBio, Inc.                          | AnaptysBio, Inc.                                        | CUSIP: 032724106<br>LEI: 529900HH4WQT03IG1A12 | Long             | EC               | CORP              | US        |      1031 | NS      | $20960.23     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Arvinas, Inc.                             | Arvinas, Inc.                                           | CUSIP: 04335A105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2567 | NS      | $19842.91     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Geron Corp.                               | Geron Corp.                                             | CUSIP: 374163103<br>LEI: 549300T282D7Z2YESL90 | Long             | EC               | CORP              | US        |     22386 | NS      | $31340.40     | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Vanda Pharmaceuticals, Inc.               | Vanda Pharmaceuticals, Inc.                             | CUSIP: 921659108<br>LEI: 529900AY8VOOQBKJ0O70 | Long             | EC               | CORP              | US        |      2073 | NS      | $9805.29      | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Aquestive Therapeutics, Inc.              | Aquestive Therapeutics, Inc.                            | CUSIP: 03843E104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3492 | NS      | $13164.84     | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Autolus Therapeutics plc                  | Autolus Therapeutics plc                                | CUSIP: 05280R100<br>LEI: 549300C0KZP8EYROLL02 | Long             | EC               | CORP              | GB        |      7046 | NS      | $10569.00     | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| ACADIA Pharmaceuticals, Inc.              | ACADIA Pharmaceuticals, Inc.                            | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |      5882 | NS      | $152873.18    | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals, Inc.              | Vertex Pharmaceuticals, Inc.                            | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |      5500 | NS      | $2150610.00   | 4.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Repurchase Agreement                      | Repurchase Agreement                                    | CUSIP: 000000000<br>LEI: N/A                  | Long             | RA               | CORP              | US        |   3378968 | PA      | $3378968.04   | 6.31%             |  |  |  | No            |                  2 | On Loan: No      |
| Cogent Biosciences, Inc.                  | Cogent Biosciences, Inc.                                | CUSIP: 19240Q201<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4004 | NS      | $48368.32     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| ARS Pharmaceuticals, Inc.                 | ARS Pharmaceuticals, Inc.                               | CUSIP: 82835W108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3451 | NS      | $40100.62     | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| United States of America                  | U.S. Treasury Bills                                     | CUSIP: 912797QE0<br>LEI: 254900HROIFWPRGM1V77 | Long             | STIV             | UST               | US        |   5000000 | PA      | $4978468.05   | 9.29%             | 2025-10-09      | None          | 0.00%                 | No            |                  2 | On Loan: No      |
| REGENXBIO, Inc.                           | REGENXBIO, Inc.                                         | CUSIP: 75901B107<br>LEI: 549300EOES47LATSET33 | Long             | EC               | CORP              | US        |      1765 | NS      | $15761.45     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| BioCryst Pharmaceuticals, Inc.            | BioCryst Pharmaceuticals, Inc.                          | CUSIP: 09058V103<br>LEI: 549300Z0INP1Z5NP6J59 | Long             | EC               | CORP              | US        |      7353 | NS      | $61103.43     | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Repurchase Agreement                      | Repurchase Agreement                                    | CUSIP: 000000000<br>LEI: N/A                  | Long             | RA               | CORP              | US        |    820023 | PA      | $820022.61    | 1.53%             |  |  |  | No            |                  2 | On Loan: No      |
| LENZ Therapeutics, Inc.                   | LENZ Therapeutics, Inc.                                 | CUSIP: 52635N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       989 | NS      | $38205.07     | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Tevogen Bio Holdings, Inc.                | Tevogen Bio Holdings, Inc.                              | CUSIP: 88165K101<br>LEI: 549300AC21G4NBK9D322 | Long             | EC               | CORP              | US        |      6464 | NS      | $5882.24      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Rapport Therapeutics, Inc.                | Rapport Therapeutics, Inc.                              | CUSIP: 75383L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1282 | NS      | $22601.66     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Climb Bio, Inc.                           | Climb Bio, Inc.                                         | CUSIP: 28658R106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2376 | NS      | $5298.48      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Legend Biotech Corp.                      | Legend Biotech Corp.                                    | CUSIP: 52490G102<br>LEI: 254900EIUFZTW136H859 | Long             | EC               | CORP              | KY        |      2872 | NS      | $99744.56     | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Xeris Biopharma Holdings, Inc.            | Xeris Biopharma Holdings, Inc.                          | CUSIP: 98422E103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5628 | NS      | $44067.24     | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Arrowhead Pharmaceuticals, Inc.           | Arrowhead Pharmaceuticals, Inc.                         | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |      4855 | NS      | $106955.65    | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Avidity Biosciences, Inc.                 | Avidity Biosciences, Inc.                               | CUSIP: 05370A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4238 | NS      | $197406.04    | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Tourmaline Bio, Inc.                      | Tourmaline Bio, Inc.                                    | CUSIP: 89157D105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       901 | NS      | $21083.40     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Zymeworks, Inc.                           | Zymeworks, Inc.                                         | CUSIP: 98985Y108<br>LEI: 894500AHOYAGYLYZJL67 | Long             | EC               | CORP              | US        |      2451 | NS      | $36299.31     | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Artiva Biotherapeutics, Inc.              | Artiva Biotherapeutics, Inc.                            | CUSIP: 04317A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       856 | NS      | $2696.40      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Immunovant, Inc.                          | Immunovant, Inc.                                        | CUSIP: 45258J102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6007 | NS      | $88242.83     | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Amphastar Pharmaceuticals, Inc.           | Amphastar Pharmaceuticals, Inc.                         | CUSIP: 03209R103<br>LEI: 54930055TH0ZLSAQMJ38 | Long             | EC               | CORP              | US        |      1656 | NS      | $50706.72     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| GRAIL, Inc.                               | GRAIL, Inc.                                             | CUSIP: 384747101<br>LEI: 2549009XSNESW3VE8024 | Long             | EC               | CORP              | US        |      1266 | NS      | $41512.14     | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                       | Total Return Swap                                       | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |      1919 | NC      | $-53251.57    | -0.10%            |  |  |  | No            |                  2 | On Loan: No      |
| Silence Therapeutics plc                  | Silence Therapeutics plc                                | CUSIP: 82686Q101<br>LEI: 213800SSURRJBX85SQ91 | Long             | EC               | CORP              | GB        |      1652 | NS      | $7946.12      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Vir Biotechnology, Inc.                   | Vir Biotechnology, Inc.                                 | CUSIP: 92764N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4860 | NS      | $24008.40     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Prime Medicine, Inc.                      | Prime Medicine, Inc.                                    | CUSIP: 74168J101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4616 | NS      | $14955.84     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Third Harmonic Bio, Inc.                  | Third Harmonic Bio, Inc.                                | CUSIP: 88427A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1662 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Akero Therapeutics, Inc.                  | Akero Therapeutics, Inc.                                | CUSIP: 00973Y108<br>LEI: 549300SI3KG74LBE2955 | Long             | EC               | CORP              | US        |      2803 | NS      | $130984.19    | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Viatris, Inc.                             | Viatris, Inc.                                           | CUSIP: 92556V106<br>LEI: 254900ZZTSW7NL773X71 | Long             | EC               | CORP              | US        |     41252 | NS      | $435208.60    | 0.81%             |  |  |  | No            |                  1 | On Loan: No      |
| Maravai LifeSciences Holdings, Inc.       | Maravai LifeSciences Holdings, Inc., Class A            | CUSIP: 56600D107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5059 | NS      | $12242.78     | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Intellia Therapeutics, Inc.               | Intellia Therapeutics, Inc.                             | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |      3638 | NS      | $41309.49     | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Supernus Pharmaceuticals, Inc.            | Supernus Pharmaceuticals, Inc.                          | CUSIP: 868459108<br>LEI: 549300GRM36VBKISYJ58 | Long             | EC               | CORP              | US        |      1967 | NS      | $88751.04     | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Mesoblast Ltd.                            | Mesoblast Ltd.                                          | CUSIP: 590717401<br>LEI: 529900J5ALF3JG921927 | Long             | EC               | CORP              | AU        |      1596 | NS      | $22072.68     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Precigen, Inc.                            | Precigen, Inc.                                          | CUSIP: 74017N105<br>LEI: 549300XCWNQU35K64G19 | Long             | EC               | CORP              | US        |     10376 | NS      | $46795.76     | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| EyePoint Pharmaceuticals, Inc.            | EyePoint Pharmaceuticals, Inc.                          | CUSIP: 30233G209<br>LEI: 549300QE1RU34T50MR69 | Long             | EC               | CORP              | US        |      2419 | NS      | $27987.83     | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Aurinia Pharmaceuticals, Inc.             | Aurinia Pharmaceuticals, Inc.                           | CUSIP: 05156V102<br>LEI: 5299008YP2BW4570ML28 | Long             | EC               | CORP              | CA        |      4747 | NS      | $56916.53     | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Scholar Rock Holding Corp.                | Scholar Rock Holding Corp.                              | CUSIP: 80706P103<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |      3336 | NS      | $108920.40    | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| ANI Pharmaceuticals, Inc.                 | ANI Pharmaceuticals, Inc.                               | CUSIP: 00182C103<br>LEI: 5493000T6CXTND40YH31 | Long             | EC               | CORP              | US        |       762 | NS      | $71247.00     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Altimmune, Inc.                           | Altimmune, Inc.                                         | CUSIP: 02155H200<br>LEI: 549300EOYCQ8SW3NVE64 | Long             | EC               | CORP              | US        |      2851 | NS      | $10919.33     | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Rigel Pharmaceuticals, Inc.               | Rigel Pharmaceuticals, Inc.                             | CUSIP: 766559702<br>LEI: 529900KPTNUS5J8K9K66 | Long             | EC               | CORP              | US        |       629 | NS      | $24436.65     | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Harrow, Inc.                              | Harrow, Inc.                                            | CUSIP: 415858109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1289 | NS      | $50271.00     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Protagonist Therapeutics, Inc.            | Protagonist Therapeutics, Inc.                          | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2179 | NS      | $128669.95    | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| ImmunityBio, Inc.                         | ImmunityBio, Inc.                                       | CUSIP: 45256X103<br>LEI: 529900J9XLBR4HFL4B83 | Long             | EC               | CORP              | US        |     31022 | NS      | $72591.48     | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| INVESCO GOVT AND AGCY LEX                 | INVESCO GOVERNMENT & AGENCY PORTFOLIO OPEN-END FUND USD | CUSIP: 825252885<br>LEI: O37NHJVF7S22I1ONOU83 | Long             | STIV             | RF                | US        |    424069 | NS      | $424068.75    | 0.79%             |  |  |  | No            |                  1 | On Loan: No      |
| Travere Therapeutics, Inc.                | Travere Therapeutics, Inc.                              | CUSIP: 89422G107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3123 | NS      | $54652.50     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| TScan Therapeutics, Inc.                  | TScan Therapeutics, Inc.                                | CUSIP: 89854M101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1837 | NS      | $3306.60      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Bridgebio Pharma, Inc.                    | Bridgebio Pharma, Inc.                                  | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |      6672 | NS      | $345342.72    | 0.64%             |  |  |  | No            |                  1 | On Loan: No      |
| BeOne Medicines Ltd.                      | BeOne Medicines Ltd.                                    | CUSIP: 07725L102<br>LEI: 549300JFUK6FRD5MH739 | Long             | EC               | CORP              | CH        |      1453 | NS      | $444690.65    | 0.83%             |  |  |  | No            |                  1 | On Loan: No      |
| Cartesian Therapeutics, Inc.              | Cartesian Therapeutics, Inc.                            | CUSIP: 816212112<br>LEI: 529900NMN0LACZOL7C43 | Long             |  | CORP              | US        |      9785 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Adaptive Biotechnologies Corp.            | Adaptive Biotechnologies Corp.                          | CUSIP: 00650F109<br>LEI: 549300ZTF7OT1FW66Q96 | Long             | EC               | CORP              | US        |      5340 | NS      | $70381.20     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Rocket Pharmaceuticals, Inc.              | Rocket Pharmaceuticals, Inc.                            | CUSIP: 77313F106<br>LEI: 549300R7VV82YUIN4Y93 | Long             | EC               | CORP              | US        |      3787 | NS      | $12421.36     | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Larimar Therapeutics, Inc.                | Larimar Therapeutics, Inc.                              | CUSIP: 517125100<br>LEI: 529900NCBZHTTJV6HX73 | Long             | EC               | CORP              | US        |      2252 | NS      | $8152.24      | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcellx, Inc.                             | Arcellx, Inc.                                           | CUSIP: 03940C100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1938 | NS      | $134477.82    | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Amgen, Inc.                               | Amgen, Inc.                                             | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |      8438 | NS      | $2427696.98   | 4.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Kiniksa Pharmaceuticals International plc | Kiniksa Pharmaceuticals International plc, Class A      | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | GB        |      1488 | NS      | $49833.12     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| C4 Therapeutics, Inc.                     | C4 Therapeutics, Inc.                                   | CUSIP: 12529R107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2497 | NS      | $6492.20      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Halozyme Therapeutics, Inc.               | Halozyme Therapeutics, Inc.                             | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |      4330 | NS      | $316739.50    | 0.59%             |  |  |  | No            |                  1 | On Loan: No      |
| CorMedix, Inc.                            | CorMedix, Inc.                                          | CUSIP: 21900C308<br>LEI: 5299006YIA3L0MBW8358 | Long             | EC               | CORP              | US        |      2386 | NS      | $35384.38     | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| SIGA Technologies, Inc.                   | SIGA Technologies, Inc.                                 | CUSIP: 826917106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2513 | NS      | $21084.07     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Spyre Therapeutics, Inc.                  | Spyre Therapeutics, Inc.                                | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |      2122 | NS      | $34991.78     | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| KalVista Pharmaceuticals, Inc.            | KalVista Pharmaceuticals, Inc.                          | CUSIP: 483497103<br>LEI: 529900Q7IDA3WUGRZA51 | Long             | EC               | CORP              | US        |      1748 | NS      | $23528.08     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Krystal Biotech, Inc.                     | Krystal Biotech, Inc.                                   | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |      1017 | NS      | $150210.90    | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Lyell Immunopharma, Inc.                  | Lyell Immunopharma, Inc.                                | CUSIP: 55083R203<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       520 | NS      | $5761.60      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                       | Total Return Swap                                       | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |      3232 | NC      | $36301.06     | 0.07%             |  |  |  | No            |                  2 | On Loan: No      |
| Monte Rosa Therapeutics, Inc.             | Monte Rosa Therapeutics, Inc.                           | CUSIP: 61225M102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2161 | NS      | $10372.80     | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Innoviva, Inc.                            | Innoviva, Inc.                                          | CUSIP: 45781M101<br>LEI: 549300ACOX4QTBES6535 | Long             | EC               | CORP              | US        |      2205 | NS      | $45048.15     | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Personalis, Inc.                          | Personalis, Inc.                                        | CUSIP: 71535D106<br>LEI: 549300EZ2NYFK7H0US48 | Long             | EC               | CORP              | US        |      3105 | NS      | $15183.45     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Relay Therapeutics, Inc.                  | Relay Therapeutics, Inc.                                | CUSIP: 75943R102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6026 | NS      | $21633.34     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Regeneron Pharmaceuticals, Inc.           | Regeneron Pharmaceuticals, Inc.                         | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |      3696 | NS      | $2146267.20   | 4.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Mind Medicine MindMed, Inc.               | Mind Medicine MindMed, Inc.                             | CUSIP: 60255C885<br>LEI: 549300QY8KN1O6RPFJ13 | Long             | EC               | CORP              | CA        |      2655 | NS      | $23576.40     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Cartesian Therapeutics, Inc.              | Cartesian Therapeutics, Inc.                            | CUSIP: 816212302<br>LEI: 529900NMN0LACZOL7C43 | Long             | EC               | CORP              | US        |       911 | NS      | $9155.55      | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Tectonic Therapeutic, Inc.                | Tectonic Therapeutic, Inc.                              | CUSIP: 878972108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       655 | NS      | $16728.70     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| CRISPR Therapeutics AG                    | CRISPR Therapeutics AG                                  | CUSIP: N/A<br>LEI: 506700O6IRRIQLT3W370       | Long             | EC               | CORP              | CH        |      3035 | NS      | $157304.05    | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Pyxis Oncology, Inc.                      | Pyxis Oncology, Inc.                                    | CUSIP: 747324101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2178 | NS      | $2787.84      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Gilead Sciences, Inc.                     | Gilead Sciences, Inc.                                   | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |     22091 | NS      | $2495620.27   | 4.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Sana Biotechnology, Inc.                  | Sana Biotechnology, Inc.                                | CUSIP: 799566104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7927 | NS      | $24256.62     | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Guardant Health, Inc.                     | Guardant Health, Inc.                                   | CUSIP: 40131M109<br>LEI: 254900M8C3E5VC8BR186 | Long             | EC               | CORP              | US        |      4355 | NS      | $293614.10    | 0.55%             |  |  |  | No            |                  1 | On Loan: No      |
| PepGen, Inc.                              | PepGen, Inc.                                            | CUSIP: 713317105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1148 | NS      | $1331.68      | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Omeros Corp.                              | Omeros Corp.                                            | CUSIP: 682143102<br>LEI: 549300CJWLXX2MXVVV71 | Long             | EC               | CORP              | US        |      2060 | NS      | $8569.60      | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Apellis Pharmaceuticals, Inc.             | Apellis Pharmaceuticals, Inc.                           | CUSIP: 03753U106<br>LEI: 254900HS0ZFRXXSB9D42 | Long             | EC               | CORP              | US        |      4418 | NS      | $121804.26    | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Incyte Corp.                              | Incyte Corp.                                            | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |      6802 | NS      | $575517.22    | 1.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Repurchase Agreement                      | Repurchase Agreement                                    | CUSIP: 000000000<br>LEI: N/A                  | Long             | RA               | CORP              | US        |    512514 | PA      | $512514.13    | 0.96%             |  |  |  | No            |                  2 | On Loan: No      |
| Structure Therapeutics, Inc.              | Structure Therapeutics, Inc.                            | CUSIP: 86366E106<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |      2093 | NS      | $40394.90     | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| scPharmaceuticals, Inc.                   | scPharmaceuticals, Inc.                                 | CUSIP: 810648105<br>LEI: 549300F55SN4ZR2OA180 | Long             | EC               | CORP              | US        |      1855 | NS      | $10202.50     | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Y-mAbs Therapeutics, Inc.                 | Y-mAbs Therapeutics, Inc.                               | CUSIP: 984241109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1591 | NS      | $13603.05     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Grifols SA                                | Grifols SA                                              | CUSIP: 398438408<br>LEI: 959800HSSNXWRKBK4N60 | Long             | EC               | CORP              | ES        |      4288 | NS      | $42751.36     | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Denali Therapeutics, Inc.                 | Denali Therapeutics, Inc.                               | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |      5111 | NS      | $78044.97     | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| AC Immune SA                              | AC Immune SA                                            | CUSIP: N/A<br>LEI: 967600VLQ0ZC2HSOG765       | Long             | EC               | CORP              | CH        |      3529 | NS      | $7199.16      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Sanofi SA                                 | Sanofi SA                                               | CUSIP: 80105N105<br>LEI: 549300E9PC51EN656011 | Long             | EC               | CORP              | FR        |      9891 | NS      | $489406.68    | 0.91%             |  |  |  | No            |                  1 | On Loan: No      |
| AbCellera Biologics, Inc.                 | AbCellera Biologics, Inc.                               | CUSIP: 00288U106<br>LEI: 9845000861BC95FF9F73 | Long             | EC               | CORP              | CA        |     10491 | NS      | $43852.38     | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Immunocore Holdings plc                   | Immunocore Holdings plc                                 | CUSIP: 45258D105<br>LEI: 213800IUE3DFS84BVN18 | Long             | EC               | CORP              | GB        |      1395 | NS      | $44946.90     | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| CureVac NV                                | CureVac NV                                              | CUSIP: N/A<br>LEI: 724500BUT8GAG9LMYN56       | Long             | EC               | CORP              | NL        |      7912 | NS      | $42487.44     | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| OnKure Therapeutics, Inc.                 | OnKure Therapeutics, Inc., Class A                      | CUSIP: 68277Q105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       452 | NS      | $1243.00      | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| BioNTech SE                               | BioNTech SE                                             | CUSIP: 09075V102<br>LEI: 894500UZJ5LG1F8J1U58 | Long             | EC               | CORP              | DE        |      3510 | NS      | $351000.00    | 0.65%             |  |  |  | No            |                  1 | On Loan: No      |
| Zevra Therapeutics, Inc.                  | Zevra Therapeutics, Inc.                                | CUSIP: 488445206<br>LEI: 254900CU6T74V18Y1W18 | Long             | EC               | CORP              | US        |      1922 | NS      | $17432.54     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Foghorn Therapeutics, Inc.                | Foghorn Therapeutics, Inc.                              | CUSIP: 344174107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1957 | NS      | $9902.42      | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Arbutus Biopharma Corp.                   | Arbutus Biopharma Corp.                                 | CUSIP: 03879J100<br>LEI: 25490064CESONAUIAS23 | Long             | EC               | CORP              | CA        |      6734 | NS      | $24983.14     | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Vericel Corp.                             | Vericel Corp.                                           | CUSIP: 92346J108<br>LEI: 54930076YM3PLTDR4B91 | Long             | EC               | CORP              | US        |      1768 | NS      | $64284.48     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Trevi Therapeutics, Inc.                  | Trevi Therapeutics, Inc.                                | CUSIP: 89532M101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3575 | NS      | $25936.63     | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Nkarta, Inc.                              | Nkarta, Inc.                                            | CUSIP: 65487U108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2495 | NS      | $5289.40      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Voyager Therapeutics, Inc.                | Voyager Therapeutics, Inc.                              | CUSIP: 92915B106<br>LEI: 54930082S4XVR0ZWCC74 | Long             | EC               | CORP              | US        |      1946 | NS      | $6538.56      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Repurchase Agreement                      | Repurchase Agreement                                    | CUSIP: 000000000<br>LEI: N/A                  | Long             | RA               | CORP              | US        |    205006 | PA      | $205005.65    | 0.38%             |  |  |  | No            |                  2 | On Loan: No      |
| Harmony Biosciences Holdings, Inc.        | Harmony Biosciences Holdings, Inc.                      | CUSIP: 413197104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2016 | NS      | $74370.24     | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Ocular Therapeutix, Inc.                  | Ocular Therapeutix, Inc.                                | CUSIP: 67576A100<br>LEI: 529900ABAWFXOHSIHG03 | Long             | EC               | CORP              | US        |      5600 | NS      | $68376.00     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Avadel Pharmaceuticals plc                | Avadel Pharmaceuticals plc                              | CUSIP: N/A<br>LEI: 549300E27PTSG2RHC762       | Long             | EC               | CORP              | IE        |      3399 | NS      | $50169.24     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Acrivon Therapeutics, Inc.                | Acrivon Therapeutics, Inc.                              | CUSIP: 004890109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1101 | NS      | $1475.34      | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Erasca, Inc.                              | Erasca, Inc.                                            | CUSIP: 29479A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      9959 | NS      | $15635.63     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Repurchase Agreement                      | Repurchase Agreement                                    | CUSIP: 000000000<br>LEI: N/A                  | Long             | RA               | CORP              | US        |   1127531 | PA      | $1127531.09   | 2.10%             |  |  |  | No            |                  2 | On Loan: No      |
| Compass Pathways plc                      | Compass Pathways plc                                    | CUSIP: 20451W101<br>LEI: 213800N7CUZIC6QSTZ31 | Long             | EC               | CORP              | GB        |      3192 | NS      | $14108.64     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Tyra Biosciences, Inc.                    | Tyra Biosciences, Inc.                                  | CUSIP: 90240B106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1870 | NS      | $23692.90     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Moderna, Inc.                             | Moderna, Inc.                                           | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |     13593 | NS      | $327455.37    | 0.61%             |  |  |  | No            |                  1 | On Loan: No      |
| Dynavax Technologies Corp.                | Dynavax Technologies Corp.                              | CUSIP: 268158201<br>LEI: 549300T5URIXWDILX594 | Long             | EC               | CORP              | US        |      4221 | NS      | $42716.52     | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Alkermes plc                              | Alkermes plc                                            | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | IE        |      5802 | NS      | $168083.94    | 0.31%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                       | Total Return Swap                                       | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |      3675 | NC      | $-4094251.72  | -7.64%            |  |  |  | No            |                  2 | On Loan: No      |
| Veracyte, Inc.                            | Veracyte, Inc.                                          | CUSIP: 92337F107<br>LEI: 529900ESWZRHXOW27Z37 | Long             | EC               | CORP              | US        |      2754 | NS      | $83556.36     | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Anavex Life Sciences Corp.                | Anavex Life Sciences Corp.                              | CUSIP: 032797300<br>LEI: 549300K1I5L8COCQ8W36 | Long             | EC               | CORP              | US        |      3002 | NS      | $28939.28     | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Terns Pharmaceuticals, Inc.               | Terns Pharmaceuticals, Inc.                             | CUSIP: 880881107<br>LEI: 254900S1ZDQMF4MYP709 | Long             | EC               | CORP              | US        |      3072 | NS      | $21381.12     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Repurchase Agreement                      | Repurchase Agreement                                    | CUSIP: 000000000<br>LEI: N/A                  | Long             | RA               | CORP              | US        |   2562571 | PA      | $2562570.65   | 4.78%             |  |  |  | No            |                  2 | On Loan: No      |
| Neumora Therapeutics, Inc.                | Neumora Therapeutics, Inc.                              | CUSIP: 640979100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5684 | NS      | $9833.32      | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2025-09-30

**Name of Applicant:** ProShares Trust

**Signature:** Maria Clem Sell

**Name of Signer:** Maria Clem Sell

**Title:** Treasurer