# EDGAR Filing Document

**Accession Number:** 0001493215
**File Stem:** 0001493152-23-004608
**Filing Date:** 2023-2
**Character Count:** 12293
**Document Hash:** 90550f4117d6e330805d2777f8f344e0
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001493152-23-004608.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001493152-23-004608

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**EFFECTIVENESS DATE**: 20230214

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** RTW INVESTMENTS, LP
- **CENTRAL INDEX KEY:** 0001493215
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-16670
- **FILM NUMBER:** 23622698

**BUSINESS ADDRESS:**
- **STREET 1:** 40 10TH AVENUE
- **STREET 2:** 7TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10014
- **BUSINESS PHONE:** 646-597-6980

**MAIL ADDRESS:**
- **STREET 1:** 40 10TH AVENUE
- **STREET 2:** 7TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10014

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** RTW INVESTMENTS, LLC
- **DATE OF NAME CHANGE:** 20100602

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2022

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** RTW INVESTMENTS LP<br>**Address:** 40 10TH AVENUE<br>7Th FLOOR<br>NEW YORK, NY 10014

**Form 13F File Number:** 028-16670

**CRD Number (if applicable):** 000153232

**SEC File Number (if applicable):** 801-78183

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Roderick Wong<br>**Title:** Managing Partner<br>**Phone:** 646-597-6980

**Signature, Place, and Date of Signing:**

/s/ Roderick Wong  New York, NY  02-14-2023<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 3

**Form 13F Information Table Entry Total:** 77

**Form 13F Information Table Value Total:** $4898669194

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

| No.   | Name                            | Form 13F File Number   |
|:---|:---|:---|
|  | RTW MASTER FUND LTD.            | 028-16671              |
|  | RTW Innovation Master Fund Ltd. | 028-19525              |
|  | RTW Venture Fund Ltd            | 028-19571              |

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| 10X GENOMICS INC | CL A COM | 88025U109 |  | 31797252 | 872592 | SH |  | SOLE | 123 | 872592 | 0 | 0 |
| 908 DEVICES INC | COM | 65443P102 |  | 2377440 | 312000 | SH |  | SOLE | 123 | 312000 | 0 | 0 |
| AADI BIOSCIENCE INC | COM | 00032Q104 |  | 9811114 | 764701 | SH |  | SOLE | 123 | 764701 | 0 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 |  | 58441333 | 3670938 | SH |  | SOLE | 123 | 3670938 | 0 | 0 |
| ADICET BIO INC | COM | 007002108 |  | 37918760 | 4241472 | SH |  | SOLE | 123 | 4241472 | 0 | 0 |
| AKOYA BIOSCIENCES INC | COM | 00974H104 |  | 4630110 | 483815 | SH |  | SOLE | 123 | 483815 | 0 | 0 |
| ALLAKOS INC | COM | 01671P100 |  | 13838270 | 1643500 | SH |  | SOLE | 123 | 1643500 | 0 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 |  | 400050979 | 1683362 | SH |  | SOLE | 123 | 1683362 | 0 | 0 |
| APYX MEDICAL CORPORATION | COM | 03837C106 |  | 7951973 | 3398279 | SH |  | SOLE | 123 | 3398279 | 0 | 0 |
| ARGENX SE | SPONSORED ADR | 04016X101 |  | 182669932 | 482195 | SH |  | SOLE | 123 | 482195 | 0 | 0 |
| ARYA SCIENCES ACQU CORP IV | CL A | G31659108 |  | 5050000 | 500000 | SH |  | SOLE | 123 | 500000 | 0 | 0 |
| ARYA SCIENCES ACQUISITN CORP | CLASS A ORD SHS | G31658100 |  | 5045000 | 500000 | SH |  | SOLE | 123 | 500000 | 0 | 0 |
| AVADEL PHARMACEUTICALS PLC | SPONSORED ADR | 05337M104 |  | 41112283 | 5741939 | SH |  | SOLE | 123 | 5741939 | 0 | 0 |
| AVIDITY BIOSCIENCES INC | COM | 05370A108 |  | 124387510 | 5605566 | SH |  | SOLE | 123 | 5605566 | 0 | 0 |
| AXONICS INC | COM | 05465P101 |  | 55337424 | 884974 | SH |  | SOLE | 123 | 884974 | 0 | 0 |
| AXSOME THERAPEUTICS INC | COM | 05464T104 |  | 229884577 | 2980482 | SH |  | SOLE | 123 | 2980482 | 0 | 0 |
| BICYCLE THERAPEUTICS PLC | SPONSORED ADS | 088786108 |  | 37254175 | 1258587 | SH |  | SOLE | 123 | 1258587 | 0 | 0 |
| BRAINSWAY LTD | SPONSORED ADS | 10501L106 |  | 3957881 | 1602381 | SH |  | SOLE | 123 | 1602381 | 0 | 0 |
| C4 THERAPEUTICS INC | COM STK | 12529R107 |  | 16634885 | 2819472 | SH |  | SOLE | 123 | 2819472 | 0 | 0 |
| CASTLE BIOSCIENCES INC | COM | 14843C105 |  | 12170062 | 516995 | SH |  | SOLE | 123 | 516995 | 0 | 0 |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 |  | 137463463 | 3084215 | SH |  | SOLE | 123 | 3084215 | 0 | 0 |
| CINCOR PHARMA INC | COM | 17240Y109 |  | 17079474 | 1389705 | SH |  | SOLE | 123 | 1389705 | 0 | 0 |
| CUTERA INC | COM | 232109108 |  | 79537409 | 1798675 | SH |  | SOLE | 123 | 1798675 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 117949752 | 2574198 | SH |  | SOLE | 123 | 2574198 | 0 | 0 |
| DERMTECH INC | COM | 24984K105 |  | 4811490 | 2718356 | SH |  | SOLE | 123 | 2718356 | 0 | 0 |
| ESTABLISHMENT LABS HLDGS INC | COM | G31249108 |  | 155862160 | 2374138 | SH |  | SOLE | 123 | 2374138 | 0 | 0 |
| EXAGEN INC | COM | 30068X103 |  | 3274406 | 1364336 | SH |  | SOLE | 123 | 1364336 | 0 | 0 |
| FULCRUM THERAPEUTICS INC | COM | 359616109 |  | 36351071 | 4993279 | SH |  | SOLE | 123 | 4993279 | 0 | 0 |
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 |  | 21082262 | 2168957 | SH |  | SOLE | 123 | 2168957 | 0 | 0 |
| GLOBUS MED INC | CL A | 379577208 |  | 55530565 | 747685 | SH |  | SOLE | 123 | 747685 | 0 | 0 |
| GUARDANT HEALTH INC | COM | 40131M109 |  | 11720126 | 430887 | SH |  | SOLE | 123 | 430887 | 0 | 0 |
| HEALTH SCIENCES ACQ CORP 2 | ORD SHS | G4411D109 |  | 9980000 | 1000000 | SH |  | SOLE | 12 | 1000000 | 0 | 0 |
| ILLUMINA INC | COM | 452327109 |  | 114116625 | 564375 | SH |  | SOLE | 123 | 564375 | 0 | 0 |
| IMMATICS N.V | SHS | N44445109 |  | 7359950 | 845000 | SH |  | SOLE | 123 | 845000 | 0 | 0 |
| IMMUNIC INC | COM | 4525EP101 |  | 5405806 | 3861290 | SH |  | SOLE | 123 | 3861290 | 0 | 0 |
| IMMUNOCORE HLDGS PLC | ADS | 45258D105 |  | 317270507 | 5559322 | SH |  | SOLE | 123 | 5559322 | 0 | 0 |
| IVERIC BIO INC | COM | 46583P102 |  | 17583776 | 821288 | SH |  | SOLE | 123 | 821288 | 0 | 0 |
| JOHNSON  JOHNSON | COM | 478160104 |  | 3202135 | 18127 | SH |  | SOLE | 123 | 18127 | 0 | 0 |
| JOUNCE THERAPEUTICS INC | COM | 481116101 |  | 5668039 | 5106341 | SH |  | SOLE | 123 | 5106341 | 0 | 0 |
| MASIMO CORP | COM | 574795100 |  | 222145889 | 1501493 | SH |  | SOLE | 123 | 1501493 | 0 | 0 |
| MEDICUS SCIENCES ACQUISITION | *W EXP 02/12/202 | G5960S124 |  | 3000 | 33331 | SH |  | SOLE | 123 | 33331 | 0 | 0 |
| MEDICUS SCIENCES ACQUISITION | CL A SHS | G5960S108 |  | 3021000 | 300000 | SH |  | SOLE | 123 | 300000 | 0 | 0 |
| MILESTONE PHARMACEUTICALS IN | COM | 59935V107 |  | 17087804 | 4315102 | SH |  | SOLE | 123 | 4315102 | 0 | 0 |
| MIRATI THERAPEUTICS INC | COM | 60468T105 |  | 165069495 | 3643114 | SH |  | SOLE | 123 | 3643114 | 0 | 0 |
| MIROMATRIX MED INC | COM | 60471P108 |  | 837200 | 280000 | SH |  | SOLE | 123 | 280000 | 0 | 0 |
| MONTE ROSA THERAPEUTICS INC | COM | 61225M102 |  | 9242893 | 1214572 | SH |  | SOLE | 123 | 1214572 | 0 | 0 |
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 |  | 5250000 | 500000 | SH |  | SOLE | 123 | 500000 | 0 | 0 |
| NATERA INC | COM | 632307104 |  | 104814898 | 2609283 | SH |  | SOLE | 123 | 2609283 | 0 | 0 |
| NAUTILUS BIOTECHNOLOGY INC | COM | 63909J108 |  | 1080000 | 600000 | SH |  | SOLE | 123 | 600000 | 0 | 0 |
| NYXOAH S A | SHS | B6S7WD106 |  | 1347265 | 269993 | SH |  | SOLE | 123 | 269993 | 0 | 0 |
| OLINK HLDG AB | SPONSORED ADS | 680710100 |  | 24921079 | 981918 | SH |  | SOLE | 123 | 981918 | 0 | 0 |
| OUTSET MED INC | COM | 690145107 |  | 23487215 | 909652 | SH |  | SOLE | 123 | 909652 | 0 | 0 |
| OYSTER PT PHARMA INC | COM | 69242L106 |  | 25746593 | 2304977 | SH |  | SOLE | 123 | 2304977 | 0 | 0 |
| PENUMBRA INC | COM | 70975L107 |  | 155359613 | 698371 | SH |  | SOLE | 123 | 698371 | 0 | 0 |
| PMV PHARMACEUTICALS INC | COM | 69353Y103 |  | 37905204 | 4356920 | SH |  | SOLE | 123 | 4356920 | 0 | 0 |
| PROMETHEUS BIOSCIENCES INC | COM | 74349U108 |  | 368973330 | 3354303 | SH |  | SOLE | 123 | 3354303 | 0 | 0 |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 |  | 39188567 | 3591986 | SH |  | SOLE | 123 | 3591986 | 0 | 0 |
| PTC THERAPEUTICS INC | COM | 69366J200 |  | 214339322 | 5615387 | SH |  | SOLE | 123 | 5615387 | 0 | 0 |
| PULMONX CORP | COM | 745848101 |  | 2318250 | 275000 | SH |  | SOLE | 123 | 275000 | 0 | 0 |
| REGENXBIO INC | COM | 75901B107 |  | 41852901 | 1845366 | SH |  | SOLE | 123 | 1845366 | 0 | 0 |
| RELMADA THERAPEUTICS INC | COM | 75955J402 |  | 7216706 | 2067824 | SH |  | SOLE | 123 | 2067824 | 0 | 0 |
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 |  | 346149698 | 17687772 | SH |  | SOLE | 123 | 17687772 | 0 | 0 |
| ROIVANT SCIENCES LTD | SHS | G76279101 |  | 6413709 | 802717 | SH |  | SOLE | 123 | 802717 | 0 | 0 |
| SCIENCE 37 HOLDINGS INC | COM | 808644108 |  | 1073752 | 2586108 | SH |  | SOLE | 123 | 2586108 | 0 | 0 |
| SIGHT SCIENCES INC | COM | 82657M105 |  | 8123594 | 665323 | SH |  | SOLE | 123 | 665323 | 0 | 0 |
| STOKE THERAPEUTICS INC | COM | 86150R107 |  | 35729155 | 3870981 | SH |  | SOLE | 123 | 3870981 | 0 | 0 |
| SUMMIT HEALTHCRE ACQUISTN CO | UNIT 06/03/2026 | G8566R128 |  | 5060000 | 500000 | SH |  | SOLE | 123 | 500000 | 0 | 0 |
| TARSUS PHARMACEUTICALS INC | COM | 87650L103 |  | 37355513 | 2548125 | SH |  | SOLE | 123 | 2548125 | 0 | 0 |
| TELA BIO INC | COM | 872381108 |  | 4489186 | 390364 | SH |  | SOLE | 123 | 390364 | 0 | 0 |
| TENAYA THERAPEUTICS INC | COM | 87990A106 |  | 4942088 | 2458750 | SH |  | SOLE | 123 | 2458750 | 0 | 0 |
| TERNS PHARMACEUTICALS INC | COM | 880881107 |  | 10180000 | 1000000 | SH |  | SOLE | 123 | 1000000 | 0 | 0 |
| THERMO FISHER SCIENTIFIC INC | COM | 883556102 |  | 239825495 | 435500 | SH |  | SOLE | 123 | 435500 | 0 | 0 |
| THIRD HARMONIC BIO INC | COM | 88427A107 |  | 2621654 | 609687 | SH |  | SOLE | 123 | 609687 | 0 | 0 |
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 |  | 183787172 | 3966915 | SH |  | SOLE | 123 | 3966915 | 0 | 0 |
| UROGEN PHARMA LTD | COM | M96088105 |  | 7605706 | 857464 | SH |  | SOLE | 123 | 857464 | 0 | 0 |
| VENTYX BIOSCIENCES INC | COM | 92332V107 |  | 50882801 | 1551778 | SH |  | SOLE | 123 | 1551778 | 0 | 0 |
| VERICEL CORP | COM | 92346J108 |  | 81651471 | 3099904 | SH |  | SOLE | 123 | 3099904 | 0 | 0 |

---