# EDGAR Filing Document

**Accession Number:** 0001819113
**File Stem:** 0001104659-23-028746
**Filing Date:** 2023-3
**Character Count:** 118700
**Document Hash:** fded364dae069b8f62aa3ebdf6e3c3aa
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-23-028746.hdr.sgml**: 20230306

**ACCESSION NUMBER**: 0001104659-23-028746

**CONFORMED SUBMISSION TYPE**: POS AM

**PUBLIC DOCUMENT COUNT**: 9

**FILED AS OF DATE**: 20230306

**DATE AS OF CHANGE**: 20230306

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Science 37 Holdings, Inc.
- **CENTRAL INDEX KEY:** 0001819113
- **STANDARD INDUSTRIAL CLASSIFICATION:** SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
- **IRS NUMBER:** 844278203
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** POS AM
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-260828
- **FILM NUMBER:** 23707496

**BUSINESS ADDRESS:**
- **STREET 1:** 600 CORPORATE POINTE
- **STREET 2:** SUITE 320
- **CITY:** CULVER CITY
- **STATE:** CA
- **ZIP:** 90230
- **BUSINESS PHONE:** (984)377-3737

**MAIL ADDRESS:**
- **STREET 1:** 600 CORPORATE POINTE
- **STREET 2:** SUITE 320
- **CITY:** CULVER CITY
- **STATE:** CA
- **ZIP:** 90230

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Lifesci Acquisition II Corp.
- **DATE OF NAME CHANGE:** 20200723

**As filed with the Securities and Exchange Commission on March 6, 2023**

**Registration No. 333-260828**

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

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**POST-EFFECTIVE**

**AMENDMENT NO. 3**

**TO**

**FORM S-1 ON FORM S-3**

**REGISTRATION STATEMENT**

***Under***

***The Securities Act of 1933***

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**SCIENCE 37 HOLDINGS, INC.**

(Exact name of registrant as specified in its charter)

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| | |
|:---|:---|
| **Delaware** | **84-4278203** |
| (State or other jurisdiction of<br> incorporation or organization) | (I.R.S. Employer<br> Identification Number) |

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**800 Park Offices Drive, Suite 3606**

**Research Triangle Park, North Carolina 27709**

**(984) 377-3737**

(Address, including zip code, and telephone number, including area code, of registrant's principal executive offices)

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**Christine Pellizzari**

**Chief Legal and Human Resources Officer**

**Science 37 Holdings, Inc.**

**800 Park Offices Drive, Suite 3606**

**Research Triangle Park, NC 27709**

**(984) 377-3737**

(Name, address, including zip code, and telephone number, including area code, of agent for service)

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***Copies to:***

**Jurgita Ashley**

**Thompson Hine LLP**

**3900 Key Center**

**127 Public Square**

**Cleveland, Ohio 44114**

**(216) 566-5500**

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**Approximate date of commencement of proposed sale to the public:** From time to time after the effective date of this registration statement.

If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box. ◻

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box. ⌧

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ◻

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ◻

If this Form is a registration statement pursuant to General Instruction I.D. or a post-effective amendment thereto that shall become effective upon filing with the Commission pursuant to Rule 462(e) under the Securities Act, check the following box. ◻

If this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.D. filed to register additional securities or additional classes of securities pursuant to Rule 413(b) under the Securities Act, check the following box. ◻

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

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| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ¨ | Accelerated filer | ¨ |
| Non-accelerated filer | x | Smaller reporting company | x |
|  |  | Emerging growth company | x |

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If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ◻

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**The registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the registrant shall file a further amendment which specifically states that this registration statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933, as amended, or until this registration statement shall become effective on such date as the Securities and Exchange Commission, acting pursuant to said Section 8(a), may determine.**

**EXPLANATORY NOTE**

On November 5, 2021, Science 37 Holdings, Inc. (the "Company") filed a registration statement on Form S-1 (File No. 333-260828) (as amended, the "Registration Statement") with the Securities and Exchange Commission (the "SEC"). The Registration Statement was initially declared effective by the SEC on January 25, 2022.

On March 22, 2022, the Company filed Post-Effective Amendment No. 1 to the Registration Statement as an exhibit-only filing solely to file the consent of Ernst & Young LLP with respect to its report dated March 22, 2022. On April 8, 2022, the Company filed Post-Effective Amendment No. 2 to the Registration Statement to include the information contained in the Company's Annual Report on Form 10-K for the year ended December 31, 2021, filed with the SEC on March 22, 2022, and to update certain other information in the Registration Statement.

This Post-Effective Amendment No. 3 to the Registration Statement is being filed to (i) convert the Registration Statement into a registration statement on Form S-3 and (ii) include updated information regarding selling securityholders named in the prospectus. No additional securities are being registered under this Post-Effective Amendment No. 3. All applicable registration fees were paid at the time of the original filing of the Registration Statement.

**The information in this prospectus is not complete and may be changed. We may not sell these securities until the registration statement filed with the Securities and Exchange Commission is effective. This prospectus is not an offer to sell these securities and it is not soliciting an offer to buy these securities in any state where the offer or sale is not permitted.**

**Subject to Completion, dated March 6, 2023**

**PRELIMINARY PROSPECTUS**

![](tm238343d1_posamimg001.jpg)

**Science 37 Holdings, Inc.**

**103,576,231 Shares of Common Stock**

**__________________________________**

This prospectus relates to the offer and sale from time to time by the selling securityholders named in this prospectus (the "Selling Securityholders") of up to 103,576,231 shares of common stock, par value $0.0001 per share (the "common stock"), consisting of (i) up to 20,000,000 shares of common stock (the "PIPE shares") issued in a private placement pursuant to subscription agreements entered into on May 6, 2021; (ii) up to 2,002,260 shares of common stock originally issued in a private placement to LifeSci Holdings, LLC (the "Sponsor") and certain other holders of common stock of LifeSci Acquisition II Corp. ("LSAQ"); (iii) up to 3,146,453 shares originally issued to the Sponsor in exchange for private warrants in connection with the Business Combination (as defined below); and (iv) up to 78,427,518 shares of common stock issued or issuable to certain former stockholders and other securityholders of Legacy Science 37 (as defined below) in connection with or as a result of the consummation of the Business Combination, consisting of (a) up to 56,977,921 shares of common stock, (b) up to 12,500,000 shares of common stock (the "Earn-Out Shares") that holders have the contingent right to receive upon the achievement of certain stock price-based vesting conditions, and (c) 8,949,597 shares of common stock that may be issued upon exercise of outstanding options.

On October 6, 2021, we consummated the business combination (the "Business Combination"), contemplated by the Agreement and Plan of Merger, dated May 6, 2021, by and among LSAQ, a Delaware corporation, LifeSci Acquisition II Merger Sub, Inc., a Delaware corporation and wholly-owned subsidiary of LSAQ ("Merger Sub"), and Science 37, Inc., a Delaware corporation ("Legacy Science 37") (the "Merger Agreement"). Pursuant to the Merger Agreement, Merger Sub was merged with and into Legacy Science 37, with Legacy Science 37 surviving the merger as a wholly owned subsidiary of LSAQ. Upon the closing of the Business Combination (the "Closing"), we changed our name from LifeSci Acquisition II Corp. to Science 37 Holdings, Inc.

We will not receive any proceeds from the sale of the shares by the Selling Securityholders. We will bear all costs, expenses and fees in connection with the registration of the shares of common stock. The Selling Securityholders will bear all commissions and discounts, if any, attributable to their sales of the shares of common stock. The Selling Securityholders and any of their permitted transferees may offer and sell the securities covered by this prospectus in a number of different ways and at varying prices. Additional information on the Selling Securityholders, and the times and manner in which they may offer and sell the securities under this prospectus, is provided under "Selling Securityholders" and "Plan of Distribution" in this prospectus.

Our common stock is listed on The Nasdaq Stock Market LLC ("Nasdaq") under the symbol "SNCE". On March 1, 2023, the closing sale price of our common stock as reported on the Nasdaq was $0.3226.

We are an "emerging growth company" as defined under U.S. federal securities laws and, as such, have elected to comply with reduced public company reporting requirements. This prospectus complies with the requirements that apply to an issuer that is an emerging growth company.

**Investing in our securities involves a high degree of risk. You should review carefully the risks and uncertainties described in the section titled "** **[Risk Factors](#a_006)" beginning on page 10 of this prospectus, and under similar headings in any amendments or supplements to this prospectus.**

**Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the accuracy or adequacy of this prospectus. Any representation to the contrary is a criminal offense.**

The date of this prospectus is , 2023.

**TABLE OF CONTENTS**

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| | |
|:---|:---|
| [ABOUT THIS PROSPECTUS](#a_002) | [1](#a_002) |
| [CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS](#a_003) | [2](#a_003) |
| [WHERE YOU CAN FIND MORE INFORMATION; INCORPORATION BY REFERENCE](#a_004) | [4](#a_004) |
| [SUMMARY](#a_005) | [6](#a_005) |
| [RISK FACTORS](#a_006) | [10](#a_006) |
| [USE OF PROCEEDS](#a_007) | [11](#a_007) |
| [DESCRIPTION OF CAPITAL STOCK](#a_008) | [12](#a_008) |
| [SELLING SECURITYHOLDERS](#a_009) | [16](#a_009) |
| [PLAN OF DISTRIBUTION](#a_010) | [23](#a_010) |
| [LEGAL MATTERS](#a_011) | [26](#a_011) |
| [EXPERTS](#a_012) | [26](#a_012) |

---

i

**ABOUT THIS PROSPECTUS**

This prospectus is part of a registration statement that we filed with the Securities and Exchange Commission (the "SEC") using the "shelf" registration process. Under this shelf registration process, the Selling Securityholders may, from time to time, sell or otherwise distribute the securities offered by them as described in the section titled "Plan of Distribution" in this prospectus. We will not receive any proceeds from the sale by such Selling Securityholders of the securities offered by them described in this prospectus.

We may also file a prospectus supplement or post-effective amendment to the registration statement of which this prospectus forms a part that may contain material information relating to these offerings. The prospectus supplement or post-effective amendment may also add, update or change information contained in this prospectus with respect to that offering. If there is any inconsistency between the information in this prospectus and the applicable prospectus supplement or post-effective amendment, you should rely on the prospectus supplement or post-effective amendment, as applicable. Before purchasing any securities, you should carefully read this prospectus, any post-effective amendment, and any applicable prospectus supplement, together with the additional information described under the heading "Where You Can Find More Information; Incorporation by Reference."

Neither we, nor the Selling Securityholders, have authorized anyone to provide you with any information or to make any representations other than those contained in this prospectus, any post-effective amendment, or any applicable prospectus supplement prepared by or on behalf of us or to which we have referred you. We and the Selling Securityholders take no responsibility for, and can provide no assurance as to the reliability of, any other information that others may give you. We and the Selling Securityholders will not make an offer to sell these securities in any jurisdiction where the offer or sale is not permitted. You should assume that the information appearing in this prospectus, any post-effective amendment and any applicable prospectus supplement to this prospectus is accurate only as of the date on its respective cover and that any information incorporated by reference is accurate only as of the date of the document incorporated by reference, unless we indicate otherwise. Our business, financial condition, results of operations and prospects may have changed since those dates. This prospectus incorporates by reference, and any post-effective amendment or any prospectus supplement may contain or incorporate by reference, market data and industry statistics and forecasts that are based on independent industry publications and other publicly available information. Although we believe these sources are reliable, neither we nor the Selling Securityholders guarantee the accuracy or completeness of this information and neither we nor the Selling Securityholders have independently verified this information. In addition, the market and industry data and forecasts that may be included or incorporated by reference in this prospectus, any post-effective amendment or any prospectus supplement may involve estimates, assumptions and other risks and uncertainties and are subject to change based on various factors, including those discussed under the heading "Risk Factors" contained in this prospectus, any post-effective amendment and the applicable prospectus supplement, and under similar headings in other documents that are incorporated by reference into this prospectus. Accordingly, investors should not place undue reliance on this information.

We own or have rights to trademarks, trade names and service marks that we use in connection with the operation of our business. In addition, our name, logos and website name and address are our trademarks or service marks. Solely for convenience, in some cases, the trademarks, trade names and service marks referred to in this prospectus are listed without the applicable®,™ and SM symbols, but we will assert, to the fullest extent under applicable law, our rights to these trademarks, trade names and service marks. Other trademarks, trade names and service marks appearing in this prospectus are the property of their respective owners.

As used in this prospectus, unless otherwise indicated or the context otherwise requires, references to "we," "us," "our," the "Company" and "Science 37" refer to the consolidated operations of Science 37 Holdings, Inc. and its subsidiaries. References to "LSAQ" refer to the Company prior to the consummation of the Business Combination and references to "Legacy Science 37" refer to Science 37, Inc. prior to the consummation of the Business Combination.

**CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS**

This prospectus and the documents incorporated by reference herein and any prospectus supplement delivered with this prospectus may contain forward-looking statements. We intend such forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in Section 27A of the Securities Act of 1933, as amended (the "Securities Act"), and Section 21E of the Securities Exchange Act of 1934, as amended (the "Exchange Act"). All statements other than statements of historical facts contained or incorporated by reference in this prospectus, including, but not limited to, statements regarding our future results of operations and financial position, business strategy, plans and prospects, existing and prospective products, research and development costs, timing and likelihood of success, and plans and objectives of management for future operations and results, are forward-looking statements. These forward-looking statements can generally be identified by the use of forward-looking terminology, including the terms "believes," "can," "could," "estimates," "anticipates," "expects," "seeks," "projects," "intends," "plans," "may," "might," "should," "will" or "would" or, in each case, their negative or other variations or comparable terminology, although not all forward-looking statements contain these identifying words. These statements involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements.

Factors that may impact such forward-looking statements include:

&nbsp;&nbsp;&nbsp;&nbsp;• expectations regarding the Company's strategies and future financial performance, including its future business plans or objectives,
prospective performance and opportunities and competitors, revenues, backlog conversion, products and services, pricing, operating expenses,
market trends, liquidity, cash flows and uses of cash, capital expenditures, and ability to invest in growth initiatives and pursue acquisition
opportunities;

&nbsp;&nbsp;&nbsp;&nbsp;• risks related to the Company's technology, intellectual property, data privacy and cybersecurity practices;

&nbsp;&nbsp;&nbsp;&nbsp;• risks related to the Company's reliance on third parties;

&nbsp;&nbsp;&nbsp;&nbsp;• risks related to general economic and financial market conditions, including the impact of ongoing supply chain disruptions and inflationary
cost pressures and the possibility of an economic recession; political, legal and regulatory environment; and the industries in which
the Company operates;

&nbsp;&nbsp;&nbsp;&nbsp;• the risk that the Company will need to raise additional capital to execute its business plan, which may not be available on acceptable
terms or at all;

&nbsp;&nbsp;&nbsp;&nbsp;• limited liquidity and trading of the Company's securities;

&nbsp;&nbsp;&nbsp;&nbsp;• volatility in the price of Science 37's securities due to a variety of factors, including changes in the competitive and highly
regulated industries in which Science 37 operates, variations in performance across competitors and changes in laws and regulations affecting
Science 37's business;

&nbsp;&nbsp;&nbsp;&nbsp;• geopolitical risk and changes in applicable laws or regulations;

&nbsp;&nbsp;&nbsp;&nbsp;• the possibility that the Company may be adversely affected by other economic, business, and/or competitive factors;

&nbsp;&nbsp;&nbsp;&nbsp;• operational risks; and

&nbsp;&nbsp;&nbsp;&nbsp;• litigation and regulatory enforcement risks, including the diversion of management time and attention and the additional costs and
demands resulting therefrom on the Company's resources.

Forward-looking statements contained in this prospectus are based on the Company's current expectations and beliefs and are based upon information available to us as of the date of this prospectus, and while we believe such information forms a reasonable basis for such statements, that information may be limited or incomplete. Our forward-looking statements should not be read to indicate that we have conducted an exhaustive inquiry into, or review of, all relevant information. These forward-looking statements involve a number of risks, uncertainties (some of which are beyond the Company's control) or other assumptions that may cause actual results or performance to be materially different from those expressed or implied by these forward-looking statements. Forward-looking statements are inherently uncertain, and investors are cautioned not to unduly rely upon these statements.

These risks and uncertainties include, but are not limited to, those factors discussed under the heading "Risk Factors" below. Should one or more of these risks or uncertainties materialize, or should any of the assumptions prove incorrect, actual results may vary in material respects from those projected in these forward-looking statements. Furthermore, we operate in an evolving environment. New risk factors and uncertainties may emerge from time to time, and it is not possible for management to predict all risk factors and uncertainties.

We qualify all of our forward-looking statements by these cautionary statements. The Company will not and does not undertake any obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as may be required by law.

**WHERE YOU CAN FIND MORE INFORMATION; INCORPORATION BY REFERENCE**

**Available Information**

We have filed with the SEC a registration statement under the Securities Act with respect to the shares of common stock offered hereby. This prospectus and any applicable prospectus supplement constitute a part of the registration statement, but do not contain all of the information set forth in the registration statement or the exhibits and schedules filed therewith. For further information about us and the common stock offered hereby, we refer you to the registration statement and the exhibits and schedules filed thereto. Statements contained in this prospectus or any prospectus supplement regarding the contents of any contract or any other document that is filed as an exhibit to the registration statement are not necessarily complete, and each such statement is qualified in all respects by reference to the full text of such contract or other document filed as an exhibit to the registration statement. We file periodic reports, proxy statements, and other information with the SEC pursuant to the Exchange Act. The SEC maintains an Internet website that contains reports, proxy and information statements and other information about registrants, like us, that file electronically with the SEC. The address of that site is *www.sec.gov*.

We also maintain an internet website at *www.science37.com*. Through our website, we make available, free of charge, the following documents as soon as reasonably practicable after they are electronically filed with, or furnished to, the SEC: our quarterly reports on Form 10-Q, annual reports on Form 10-K, current reports on Form 8-K, and all amendments to those reports. The information contained on, or that may be accessed through, our website is not part of, and is not incorporated into, this prospectus.

**Incorporation by Reference**

The SEC's rules allow us to "incorporate by reference" information into this prospectus, which means that we can disclose important information to you by referring you to another document filed separately with the SEC. The information incorporated by reference is deemed to be part of this prospectus, and subsequent information that we file with the SEC will automatically update and supersede that information. Any statement contained in this prospectus or a previously filed document incorporated by reference will be deemed to be modified or superseded for purposes of this prospectus to the extent that a statement contained in this prospectus or a subsequently filed document incorporated by reference modifies or replaces that statement.

This prospectus and any accompanying prospectus supplement incorporate by reference the documents set forth below that have previously been filed with the SEC:

&nbsp;&nbsp;&nbsp;&nbsp;• [our Annual Report on Form 10-K for the year ended December 31, 2022](https://www.sec.gov/ix?doc=/Archives/edgar/data/1819113/000181911323000009/snce-20221231.htm) , filed with the SEC on March 6, 2023; and

&nbsp;&nbsp;&nbsp;&nbsp;• the description of our common stock set forth in [Exhibit 4.1](https://www.sec.gov/Archives/edgar/data/1819113/000181911322000011/snce123121ex-41description.htm) of our Annual Report on Form 10-K for the fiscal year ended December 31, 2021, together with any amendment or report filed with
the SEC for the purpose of updating such description.

Notwithstanding the foregoing, information furnished under Items 2.02 and 7.01 of any Current Report on Form 8-K, including the related exhibits under Item 9.01, is not incorporated by reference in this prospectus or any prospectus supplement.

All reports and other documents we subsequently file pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act, prior to the termination of this offering, including all such documents we may file with the SEC after the date of the initial registration statement of which this prospectus forms a part and prior to the effectiveness of the registration statement, but excluding any information furnished to, rather than filed with, the SEC, will also be incorporated by reference into this prospectus and deemed to be part of this prospectus from the date of the filing of such reports and documents.

You may obtain any of the documents incorporated by reference in this prospectus from the SEC through the SEC's website at the address provided above. You also may request a copy of any document incorporated by reference in this prospectus (excluding any exhibits to those documents, unless the exhibit is specifically incorporated by reference in this document), at no cost, by writing or telephoning us at the following address and phone number:

Science 37 Holdings, Inc.

Attn: Secretary

800 Park Offices Drive, Suite 3606

Research Triangle Park, North Carolina 27709

(984) 377-3737

**SUMMARY**

*This summary highlights selected information from this prospectus and does not contain all of the information that is important to you in making an investment decision. This summary is qualified in its entirety by the more detailed information included in or incorporated by reference into this prospectus. Before making your investment decision with respect to our securities, you should carefully read this entire prospectus, any applicable prospectus supplement and the documents referred to in the section of this prospectus entitled "Where You Can Find More Information; Incorporation by Reference."*

**Overview**

Science 37 pioneered the concept of patient-centric clinical trials with a very simple premise: that clinical trials should begin with the patient.

Through its patient-centric approach, Science 37 reduces the impact of the geographic barriers associated with conventional physical clinical trial sites, enabling recruitment of virtually any patient. Science 37 believes that centering the clinical trial around the patient with personalized support addresses current industry needs around patient recruitment, retention, representation and engagement. To expand clinical trial access, Science 37 offers a unique model to existing non-research focused healthcare networks to seamlessly participate without the traditional site infrastructure costs.

**Background**

We were incorporated as LifeSci Acquisition II Corp. on December 18, 2019. On October 6, 2021, we closed the Business Combination with Legacy Science 37, as a result of which Legacy Science 37 became a wholly-owned subsidiary of ours, and we changed our name to Science 37 Holdings, Inc. While we are the legal acquirer of Legacy Science 37 in the Business Combination, Legacy Science 37 is deemed to be the accounting acquirer, and the historical financial statements of Legacy Science 37 became the historical financial statements of our Company upon the closing of the Business Combination.

**Risk Factors**

Our business is subject to a number of risks of which you should be aware before making an investment decision. You should consider carefully the risks and uncertainties described below, together with all of the other information contained in or incorporated by reference into this prospectus, including our consolidated financial statements and related notes, before deciding to invest in our securities. These risks include the following:

&nbsp;&nbsp;&nbsp;&nbsp;• Science 37 has a limited operating history on which to assess the prospects for Science 37's business, Science 37 has generated
limited revenue from sales of Science 37's products and related services, and Science 37 has incurred losses since inception. As
such, you cannot rely upon its historical operating performance to make an investment decision regarding Science 37. Science 37 anticipates
that it will continue to incur significant losses as it continues to commercialize its existing products and services and seeks to develop
and commercialize new products and services.

&nbsp;&nbsp;&nbsp;&nbsp;• Science 37 may need to raise additional funding to strengthen its core business, expand into additional markets, and extend the reach
of its operating system. This additional financing may not be available on acceptable terms, or at all. Failure to obtain this necessary
capital when needed may force Science 37 to delay, limit or terminate Science 37's product commercialization or development efforts
or other operations.

&nbsp;&nbsp;&nbsp;&nbsp;• The potential loss or non-renewal of Science 37's contracts, any delay in its customers' clinical trials or non-payment
by its customers for services that Science 37 has performed, could negatively affect its business, results of operations and financial
results.

&nbsp;&nbsp;&nbsp;&nbsp;• Science 37 depends entirely on the clinical trial market, and a downturn in this market could cause its revenues to decrease.

&nbsp;&nbsp;&nbsp;&nbsp;• Science 37 may face political, legal and compliance, operational, regulatory, economic and other risks associated with the international
expansion of its operations that Science 37 does not currently face or that are more significant than in its domestic operations.

&nbsp;&nbsp;&nbsp;&nbsp;• Science 37's business depends on the continued effectiveness and availability of its information systems, including the information
systems Science 37 uses to provide its services to its customers, and failures or breaches of these systems may materially limit or harm
its operations.

&nbsp;&nbsp;&nbsp;&nbsp;• Science 37 relies on third parties for important products, services and licenses to certain technology and intellectual property rights,
and there might be problems with such products or services or it might not be able to continue to obtain such products, services and licenses.

&nbsp;&nbsp;&nbsp;&nbsp;• Failure to comply with data privacy and security laws, regulations, and industry standards could have a material adverse effect on
our reputation, results of operations or financial condition, or have other adverse consequences.

&nbsp;&nbsp;&nbsp;&nbsp;• Science 37 incurs significant costs and obligations as a result of being a recently public company.

&nbsp;&nbsp;&nbsp;&nbsp;• The market price of our common stock has been and may continue to be highly volatile, and you may lose some or all of your investment.
In addition, we may be unable to regain compliance with Nasdaq's continued listing requirements and could be delisted from Nasdaq.

&nbsp;&nbsp;&nbsp;&nbsp;• Volatility in our share price could subject us to securities class action litigation.

**Corporate Information**

Science 37's principal office and mailing address is 800 Park Offices Drive, Suite 3606, Research Triangle Park, North Carolina 27709, its telephone number is (984) 377-3737 and its website is *www.science37.com*. The information contained on, or accessible through, Science 37's website is not incorporated by reference into this prospectus, and you should not consider any information contained on, or that can be accessed through, Science 37's website as part of this prospectus.

**Emerging Growth Company and Smaller Reporting Company Status**

We are an "emerging growth company," as defined in the Jumpstart Our Business Startups Act of 2012 (the "JOBS Act"). As an emerging growth company, we are exempt from certain requirements related to executive compensation, including, but not limited to, the requirements to hold a non-binding advisory vote on executive compensation, to provide information relating to the ratio of total compensation of our Chief Executive Officer to the median of the annual total compensation of all of our employees and to include the pay versus performance disclosure, each as required by the Dodd-Frank Wall Street Reform and Consumer Protection Act.

Section 102(b)(1) of the JOBS Act exempts emerging growth companies from being required to comply with new or revised financial accounting standards until private companies are required to comply with the new or revised financial accounting standards. The JOBS Act provides that a company can choose not to take advantage of the extended transition period and comply with the requirements that apply to non-emerging growth companies, and any such election to not take advantage of the extended transition period is irrevocable. Science 37 previously elected to avail itself of the extended transition period. During the extended transition period, it may be difficult or impossible to compare our financial results with the financial results of another public company that complies with public company effective dates for accounting standard updates because of the potential differences in accounting standards used.

We will remain an emerging growth company under the JOBS Act until the earliest of (a) December 31, 2025, (b) the last date of our fiscal year in which we have a total annual gross revenue of at least $1.235 billion, (c) the date on which we are deemed to be a "large accelerated filer" under the rules of the SEC with at least $700.0 million of outstanding common stock held by non-affiliates or (d) the date on which we have issued more than $1.0 billion in non-convertible debt securities during the previous three years.

We are also a smaller reporting company as defined in the Exchange Act. We may continue to be a smaller reporting company even after we are no longer an emerging growth company. We may take advantage of certain of the scaled disclosures available to smaller reporting companies and will be able to take advantage of these scaled disclosures for so long as (i) our voting and non-voting common stock held by non-affiliates is less than $250.0 million measured on the last business day of our second fiscal quarter or (ii) our annual revenue is less than $100.0 million during the most recently completed fiscal year and our voting and non-voting common stock held by non-affiliates is less than $700.0 million measured on the last business day of our second fiscal quarter.

**The Offering**

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| | |
|:---|:---|
| Shares of common stock offered by the Selling Securityholders | Up to 103,576,231 shares of common stock |
| Use of proceeds | We will not receive any proceeds from the sale of shares of common stock by the Selling Securityholders. |
| Risk factors | Before investing in our securities, you should carefully read and consider the information set forth in "Risk Factors," and under similar headings in any amendments or supplements to this prospectus and the documents incorporated herein by reference. |
| Nasdaq symbol | "SNCE" |

---

**RISK FACTORS**

Investing in our securities involves a high degree of risk. Before you make a decision to buy our securities, in addition to the risks and uncertainties discussed above under "Cautionary Note Regarding Forward-Looking Statements," you should carefully consider the risk factors incorporated by reference to our most recent Annual Report on Form 10-K and any subsequent Quarterly Reports on Form 10-Q or Current Reports on Form 8-K, and all other information contained in or incorporated by reference into this prospectus, as updated by our subsequent filings under the Exchange Act, and the risk factors and other information contained in any applicable prospectus supplement before acquiring any of such securities. Additional risks and uncertainties not presently known to us or that we currently believe to be immaterial may become material and adversely affect our business. The occurrence of any of these risks might cause you to lose all or part of your investment in the offered securities.

**USE OF PROCEEDS**

All of the securities offered by the Selling Securityholders pursuant to this prospectus will be sold by the Selling Securityholders for their respective accounts. We will not receive any of the proceeds from these sales.

The Selling Securityholders will pay any underwriting discounts and commissions and expenses incurred by the Selling Securityholders for brokerage, accounting, tax or legal services or any other expenses incurred by the Selling Securityholders in disposing of the securities. We will bear the costs, fees and expenses incurred in effecting the registration of the securities covered by this prospectus, including all registration and filing fees, Nasdaq listing fees and fees and expenses of our counsel and our independent registered public accounting firm.

**DESCRIPTION OF CAPITAL STOCK**

**General**

The following description of our capital stock is not complete and may not contain all the information you should consider before investing in our capital stock. The following description summarizes some of the terms of our Second Amended and Restated Certificate of Incorporation (the "certificate of incorporation") and Amended and Restated By-Laws (the "bylaws"), and of the General Corporation Law of the State of Delaware (the "DGCL"). This description is summarized from, and qualified in its entirety by reference to, our certificate of incorporation and bylaws, each of which has been publicly filed with the SEC, as well as the relevant provisions of the DGCL.

**Capital Stock**

Our authorized capital stock consists of 400,000,000 shares of common stock, par value $0.0001 per share, and 100,000,000 shares of preferred stock, par value $0.0001 per share. No shares of preferred stock have been issued or are outstanding. Unless our board of directors determines otherwise, we will issue all shares of our capital stock in uncertificated form.

**Common Stock**

Holders of shares of common stock are entitled to one vote for each share held of record on all matters submitted to a vote of stockholders. The holders of common stock do not have cumulative voting rights in the election of directors.

In the event of our liquidation, dissolution or winding up and after payment in full of all amounts required to be paid to creditors and to any future holders of preferred stock having liquidation preferences, if any, the holders of common stock will be entitled to receive pro rata our remaining assets available for distribution. Holders of common stock do not have preemptive, subscription, redemption or conversion rights. There are no redemption or sinking fund provisions applicable to the common stock. The rights, powers, preferences and privileges of holders of the common stock are subject to those of the holders of any shares of preferred stock that the board of directors may authorize and issue in the future.

**Preferred Stock**

Under the terms of the certificate of incorporation, our board of directors is authorized to direct us to issue shares of preferred stock in one or more series without stockholder approval. Our board of directors has the discretion to determine the rights, powers, preferences, privileges and restrictions, including voting rights, dividend rights, conversion rights, redemption privileges and liquidation preferences, of each series of preferred stock.

The purpose of authorizing our board of directors to issue preferred stock and determine its rights and preferences is to eliminate delays associated with a stockholder vote on specific issuances. The issuance of preferred stock, while providing flexibility in connection with possible acquisitions, future financings and other corporate purposes, could have the effect of making it more difficult for a third party to acquire, or could discourage a third party from seeking to acquire, a majority of the outstanding voting stock. Additionally, the issuance of preferred stock may adversely affect the holders of common stock by restricting dividends on the common stock, diluting the voting power of the common stock or subordinating the liquidation rights of the common stock. As a result of these or other factors, the issuance of preferred stock could have an adverse impact on the market price of the common stock.

**Dividends**

Declaration and payment of any dividend is subject to the discretion of our board of directors. The time and amount of dividends is dependent upon, among other things, our business prospects, results of operations, financial condition, cash requirements and availability, debt repayment obligations, capital expenditure needs, contractual restrictions, covenants in the agreements governing current and future indebtedness, industry trends, the provisions of Delaware law affecting the payment of dividends and distributions to stockholders and any other factors or considerations our board of directors may regard as relevant.

We currently intend to retain all available funds and any future earnings to fund the development and growth of our business, and therefore do not anticipate declaring or paying any cash dividends on our common stock in the foreseeable future.

**Anti-Takeover Provisions**

The certificate of incorporation and bylaws contain provisions that may delay, deter or discourage another party from acquiring control of us. We expect that these provisions, which are summarized below, will discourage coercive takeover practices or inadequate takeover bids. These provisions are also designed to encourage persons seeking to acquire control of us to first negotiate with our board of directors, which may result in an improvement of the terms of any such acquisition in favor of our stockholders. However, they also give our board of directors the power to discourage acquisitions that some stockholders may favor.

***Authorized but Unissued Shares***

The authorized but unissued shares of common stock and preferred stock are available for future issuance without stockholder approval, subject to any limitations imposed by the listing standards of the Nasdaq. These additional shares may be used for a variety of corporate finance transactions, acquisitions and employee benefit plans. The existence of authorized but unissued and unreserved common stock and preferred stock could make more difficult or discourage an attempt to obtain control of us by means of a proxy contest, tender offer, merger or otherwise.

***Classified Board of Directors***

Our certificate of incorporation provides that our board of directors is divided into three classes of directors, with each director serving a three-year term. As a result, approximately one-third of our board of directors will be elected each year. The classification of directors has the effect of making it more difficult for stockholders to change the composition of our board of directors.

***Stockholder Action; Special Meetings of Stockholders***

Our certificate of incorporation provides that stockholders may not take action by written consent, but may only take action at annual or special meetings of stockholders. As a result, a holder controlling a majority of capital stock would not be able to amend the bylaws or remove directors without holding a meeting of stockholders called in accordance with the bylaws. Further, our certificate of incorporation provides that only the chairperson of our board of directors, a majority of our board of directors, our Chief Executive Officer or our President may call special meetings of stockholders, thus prohibiting a stockholder from calling a special meeting. These provisions might delay the ability of stockholders to force consideration of a proposal or for stockholders controlling a majority of capital stock to take any action, including the removal of directors.

***Advance Notice Requirements for Stockholder Proposals and Director Nominations***

In addition, our bylaws establish an advance notice procedure for stockholder proposals to be brought before an annual meeting or special meeting of stockholders. Generally, in order for any matter to be "properly brought" before a meeting, the matter must be (a) specified in a notice of meeting given by or at the direction of our board of directors, (b) if not specified in a notice of meeting, otherwise brought before the meeting by our board of directors or the chairperson of the meeting, or (c) otherwise properly brought before the meeting by a stockholder present in person who (A)(1) was a stockholder both at the time of giving the notice and at the time of the meeting, (2) is entitled to vote at the meeting, and (3) has complied with the advance notice procedures specified in our bylaws or (B) properly made such proposal in accordance with Rule 14a-8 under the Exchange Act and the rules and regulations thereunder, which proposal has been included in the proxy statement for the annual meeting. Further, for business to be properly brought before an annual meeting by a stockholder, the stockholder must (a) provide timely notice in writing and in proper form to the secretary and (b) provide any updates or supplements to such notice at the times and in the forms required by our bylaws. To be timely, a stockholder's notice must be delivered to, or mailed and received at, our principal executive offices not less than 90 days nor more than 120 days prior to the one-year anniversary of the preceding year's annual meeting; *provided, however*, that if the date of the annual meeting is more than 30 days before or more than 60 days after such anniversary date, notice by the stockholder to be timely must be so delivered, or mailed and received, not later than the 90th day prior to such annual meeting or, if later, the 10th day following the day on which public disclosure of the date of such annual meeting was first made.

Stockholders at an annual meeting or special meeting may only consider proposals or nominations specified in the notice of meeting or properly brought before the meeting, as described above. These provisions could have the effect of delaying stockholder actions that are favored by the holders of a majority of the outstanding voting securities until the next stockholder meeting.

***Amendment of Certificate of Incorporation or Bylaws***

Our bylaws may be amended or repealed by a majority vote of our board of directors or by the holders of at least sixty-six and two-thirds percent of the voting power of all of the then-outstanding shares entitled to vote generally in the election of directors, voting together as a single class. The affirmative vote of a majority of our board of directors and at least sixty-six and two-thirds percent of the voting power of all of the then-outstanding shares entitled to vote, voting together as a single class, would be required to amend certain provisions of our certificate of incorporation.

**Limitations on Liability and Indemnification of Officers and Directors**

Our bylaws provide indemnification and advancement of expenses for our directors and officers to the fullest extent permitted by the DGCL, subject to certain limited exceptions. We have entered into indemnification agreements with each of our directors and officers. In some cases, the provisions of those indemnification agreements may be broader than the specific indemnification provisions contained under Delaware law. In addition, as permitted by Delaware law, our certificate of incorporation includes provisions that eliminate the personal liability of directors for monetary damages resulting from breaches of certain fiduciary duties as a director. The effect of this provision is to restrict our rights and the rights of our stockholders in derivative suits to recover monetary damages against a director for breach of fiduciary duties as a director.

These provisions may be held not to be enforceable for violations of the federal securities laws of the United States.

**Dissenters' Rights of Appraisal and Payment**

Under the DGCL, with certain exceptions, our stockholders have appraisal rights in connection with a merger or consolidation of our Company. Pursuant to Section 262 of the DGCL, stockholders who properly demand and perfect appraisal rights in connection with such merger or consolidation have the right to receive payment of the fair value of their shares as determined by the Delaware Court of Chancery.

**Stockholders' Derivative Actions**

Under the DGCL, any of our stockholders may bring an action in our name to procure a judgment in its favor, also known as a derivative action, provided that the stockholder bringing the action is a holder of our shares at the time of the transaction to which the action relates.

**Forum Selection**

Our bylaws provide that unless we consent in writing to the selection of an alternative forum, the Court of Chancery of the State of Delaware, to the fullest extent permitted by applicable law, is the sole and exclusive forum for: (i) any derivative action brought by a stockholder on behalf of the Company, (ii) any claim of breach of a fiduciary duty owed by any of our directors, officers, or stockholders to the Company or our stockholders, (iii) any claim against us arising under our certificate of incorporation, bylaws or the DGCL or (iv) any claim against us governed by the internal affairs doctrine. Our bylaws designate the federal district courts of the United States of America as the exclusive forum for the resolution of any complaint asserting a cause of action arising under the Securities Act.

**Transfer Agent and Registrar**

The transfer agent and registrar for the common stock is Continental Stock Transfer & Trust Company.

**Trading Symbol and Market**

Our common stock is listed on the Nasdaq under the symbol "SNCE."

**SELLING SECURITYHOLDERS**

The Selling Securityholders listed in the table below may from time to time offer and sell any or all of the shares of common stock set forth below pursuant to this prospectus. When we refer to the "Selling Securityholders" in this prospectus, we refer to the persons listed in the table below, and the pledgees, donees, transferees, assignees, successors and other permitted transferees that hold any of the Selling Securityholders' interest in the shares of common stock after the date of this prospectus.

The following table sets forth certain information provided by or on behalf of the Selling Securityholders concerning the common stock that may be offered from time to time by each Selling Securityholder pursuant to this prospectus. The number of shares beneficially owned by each Selling Securityholder is determined under rules issued by the SEC. Under these rules, beneficial ownership includes any shares as to which the individual or entity has sole or shared voting power or investment power. Percentage ownership is based on 116,462,029 shares of common stock outstanding as of February 27, 2023. In computing the number of shares beneficially owned by an individual or entity and the percentage ownership of that person, shares of common stock subject to options, warrants or other rights held by such person that are currently exercisable or will become exercisable or that will vest within 60 days of such date are considered outstanding, although these shares are not considered outstanding for purposes of computing the percentage ownership of any other person. Each of the Selling Securityholders listed has sole voting and investment power with respect to the shares beneficially owned by the Selling Securityholder unless noted otherwise, subject to community property laws where applicable.

The Selling Securityholders identified below may have sold, transferred or otherwise disposed of all or a portion of their securities after the date on which they provided us with information regarding their securities. Any changed or new information given to us by the Selling Securityholders, including regarding the identity of, and the securities held by, each Selling Securityholder, will be set forth in a prospectus supplement or amendments to the registration statement of which this prospectus is a part, if and when necessary. A Selling Securityholder may sell all, some or none of such securities in this offering. See "Plan of Distribution." For purposes of this table, we have assumed that the Selling Securityholders will have sold all of the securities covered by this prospectus upon the completion of the offering.

Former holders of shares of Legacy Science 37 common stock (including shares received as a result of the conversion of Legacy Science 37 preferred stock) and former holders of options to purchase shares of Legacy Science 37 are entitled to receive a pro rata share of the Earn-Out Shares, consisting of up to 12,500,000 additional shares of our common stock, if, during the three years following the consummation of the Business Combination, the volume weighted average share price of our common stock equals or exceeds the thresholds set forth below for a period of at least 20 days out of 30 consecutive trading days (each, a "Triggering Event"). The number of Earn-Out Shares issued upon the occurrence of a Triggering Event will be determined as follows:

&nbsp;&nbsp;&nbsp;&nbsp;• If the volume weighted average share price is equal to or greater than $15.00, a one-time aggregate issuance of 5,000,000 Earn-Out
Shares will be made; and

&nbsp;&nbsp;&nbsp;&nbsp;• If the volume weighted average share price is equal to or greater than $20.00, a one-time aggregate issuance of 7,500,000 Earn-Out
Shares will be made.

In respect of former holders of Legacy Science 37 options, receipt of the Earn-Out Shares is subject to continued services to the Company or one of its subsidiaries at the time of the applicable Triggering Event. If there is a change of control of Science 37 during the Earn-Out Period that will result in the holders of common stock receiving a per share price equal to or in excess of any Triggering Event threshold, then immediately prior to such change of control, any Triggering Event that has not previously occurred shall be deemed to have occurred and Science 37 shall issue the Earn-Out Shares to the former holders of shares of Legacy Science 37 common stock and former holders of Legacy Science 37 options in accordance with their respective pro rata shares.

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| | | | | |
|:---|:---|:---|:---|:---|
| **Selling Securityholder<sup>(1)</sup>** | **Shares of Common<br> Stock Beneficially<br> Owned Prior to<br> Offering<sup>(2)</sup>** | **Total Number of<br> Shares of<br> Common Stock<br> Offered<sup>(3)</sup>** | **Shares of Common<br> Stock Beneficially<br> Owned After the<br> Offered Shares are<br> Sold** | **Percentage of<br> Shares<br> Beneficially<br> Owned after<br> Shares are Sold** |
| Alyeska Master Fund, L.P.<sup>(4)</sup> | 731282 | 408736 | 322546 | \* |
| BlackRock, Inc.<sup>(5)</sup> | 1500000 | 1500000 |  |  |
| Casdin Partners Master Fund, L.P.<sup>(6)</sup> | 1800000 | 1800000 |  |  |
| Christopher Jon Ceppi<sup>(7)</sup> | 820980 | 764181 | 140227 | \* |
| Chardan Healthcare Investments LLC<sup>(8)</sup> | 200226 | 200226 |  |  |
| Citadel CEMF Investments Ltd.<sup>(9)</sup> | 1000000 | 1000000 |  |  |
| David Coman<sup>(10)</sup> | 5117002 | 5152670 | 542316 | \* |
| Jonathan Cotliar<sup>(11)</sup> | 1074315 | 953304 | 228703 | \* |
| FMB Research LLC<sup>(12)</sup> | 100000 | 100000 |  |  |
| Darcy Forman<sup>(13)</sup> | 857172 | 458713 | 448887 | \* |
| Steven Geffon<sup>(14)</sup> | 1362548 | 1030016 | 447611 | \* |
| John W. Hubbard<sup>(15)</sup> | 431481 | 454708 | 27575 | \* |
| LifeSci Entities<sup>(16)</sup> | 1945897 | 2184647 |  |  |
| Stephanie Gajdjis | 10000 | 10000 |  |  |
| Matthew Joseph Margiotta | 50000 | 50000 |  |  |
| Bob Spivak | 50000 | 50000 |  |  |
| Patrick Dolezal | 50000 | 50000 |  |  |
| Samuel Slutsky | 100000 | 100000 |  |  |
| Adam Evertts | 50000 | 50000 |  |  |
| Paul Yook | 100000 | 100000 |  |  |
| David Dobkin<sup>(17)</sup> | 500000 | 500000 |  |  |
| Dobkin GST Trust | 139403 | 139403 |  |  |
| Yehuda Michael Rice<sup>(18)</sup> | 1934542 | 1934542 |  |  |
| Andrew McDonald<sup>(19)</sup> | 1934542 | 1934542 |  |  |
| Lux Entities<sup>(20)</sup> | 12249889 | 14172487 |  |  |
| MDC Capital Partners (Ventures) LP<sup>(21)</sup> | 2345897 | 2584647 |  |  |
| Novartis Pharma AG<sup>(22)</sup> | 5461650 | 6135730 |  |  |
| Perceptive Life Sciences Master Fund, Ltd.<sup>(23)</sup> | 1500000 | 1500000 |  |  |
| Christine Pellizzari<sup>(24)</sup> | 1458205 | 1279280 | 187466 | \* |
| Pharmaceutical Product Development, LLC<sup>(25)</sup> | 17379797 | 19563047 |  |  |
| Pura Vida Investments, LLC and certain of its affiliates<sup>(26)</sup> | 1006400 | 1000000 | 6400 | \* |
| Entities affiliated with Redmile Group, LLC<sup>(27)</sup> | 19849597 | 21723548 | 41363 | \* |
| RTW Investments, LP<sup>(28)</sup> | 4039341 | 3000000 | 1039341 | \* |
| Samsara BioCapital, L.P.<sup>(29)</sup> | 800000 | 800000 |  |  |
| Velan Capital Partners LP<sup>(30)</sup> | 1200000 | 1200000 |  |  |
| Victory RS Science and Technology Fund, a series of Victory Portfolios<sup>(31)</sup> | 178320 | 178320 |  |  |
| Victory USAA Science & Technology Fund, a series of USAA Mutual Funds Trust<sup>(32)</sup> | 621680 | 621680 |  |  |
| Mike Zaranek<sup>(33)</sup> | 1605751 | 1493066 | 233348 | \* |

---

\* Less than 1%.

(1) Unless otherwise noted, the business address of each of the following entities or individuals is 800 Park Offices Drive, Suite 3606, Research Triangle Park, North Carolina 27709.

(2) Does not reflect the ownership of any Earn-Out Shares, which are issuable to certain of the Selling Stockholders if certain conditions
are met.

(3) This registration statement includes the issuance of up to 12,500,000 Earn-Out Shares. This column gives effect to the issuance of
Earn-Out Shares. Each holder of Earn-Out Shares is entitled to receive a pro rata amount of any Earn-Out Shares issued. The number of
Earn-Out Shares that may be issued to each individual or entity is subject to change as a result of the fact that, in respect of former
holders of Legacy Science 37 options, receipt of the Earn-Out Shares is subject to continued services to the Company or one of its subsidiaries
at the time of the applicable Triggering Event. Any Earn-Out Shares that may be forfeited as a result of such provision will be re-allocated
to the remaining holders of Earn-Out Shares. The number of Earn-Out Shares disclosed in this table does not reflect any pro-rata adjustments
that may occur at any time after the Closing. Includes the following Earn-Out Shares: Mr. Ceppi, 83,428; Mr. Coman, 577,984;
Mr. Cotliar, 107,692; Ms. Forman, 50,428; Mr. Geffon, 115,079; Mr. Hubbard, 50,802; LifeSci Ventures Partners II,
LP, 238,750; Lux Co-Invest Opportunities, L.P., 414,654; Lux Ventures IV, L.P., 1,507,944; MDC Capital Partners (Ventures) LP, 238,750;
Novartis Pharma AG, 674,080; Ms. Pellizzari, 8,541; Pharmaceutical Product Development, LLC, 2,183,250; RAF, L.P., 495,249; Redmile
Capital Offshore II Master Fund, Ltd., 402,328; Redmile Private Investments II, L.P., 938,055; Redmile Strategic Master Fund, LP,
79,682; and Mr. Zaranek, 120,663.

(4) Includes 408,736 PIPE shares held by Alyeska Master Fund, L.P. Alyeska Investment Group, L.P., the investment manager of Alyeska Master
Fund, L.P., has voting and investment control of the shares held by Alyeska Master Fund, L.P. Anand Parekh is the Chief Executive Officer
of Alyeska Investment Group, L.P. and may be deemed to be the beneficial owner of such shares. Mr. Parekh, however, disclaims any
beneficial ownership of the shares held by Alyeska Master Fund, L.P. The registered address of Alyeska Master Fund, L.P. is at c/o Maples
Corporate Services Limited, P.O. Box 309, Ugland House, South Church Street George Town, Grand Cayman, KY1-1104, Cayman Islands.
Alyeska Investment Group, L.P. is located at 77 W. Wacker, Suite 700, Chicago, IL 60601.

(5) Represents 1,500,000 PIPE shares held by BlackRock Health Sciences Trust II, a fund under management by a subsidiary of BlackRock, Inc.
BlackRock, Inc. is the ultimate parent holding company of such subsidiary. On behalf of such subsidiary, the applicable portfolio
managers, as managing directors (or in other capacities) of such entity, and/or the applicable investment committee members of such fund,
have voting and investment power over the shares held by the fund which is the registered holder of the referenced shares. Such portfolio
managers and/or investment committee members expressly disclaim beneficial ownership of all shares held by such fund. The address of such
fund, such subsidiary and such portfolio managers and/or investment committee members is 55 East 52nd Street, New York, NY 10055 and 60
State Street, 19th/20th Floor, Boston, MA 02109. Shares shown include only the securities being registered for resale and may not incorporate
all shares of the Company deemed to be beneficially held by the registered holder or BlackRock, Inc.

(6) Represents 1,800,000 PIPE Shares held by Casdin Partners Master Fund, L.P. The shares reflected as beneficially owned by Casdin Partners
Master Fund, LP are owned directly by Casdin Partners Master Fund, LP and may be deemed to be indirectly beneficially owned by (i) Casdin
Capital, LLC, the investment adviser to Casdin Partners Master Fund, LP, (ii) Casdin Partners GP, LLC, the general partner of Casdin
Partners Master Fund, LP, and (iii) Eli Casdin, the managing member of Casdin Capital, LLC and Casdin Partners GP, LLC. Each
of Casdin Capital, LLC, Casdin Partners GP, LLC and Eli Casdin disclaims beneficial ownership of such securities except to the extent
of their respective pecuniary interest therein. Casdin Partners Master Fund, L.P. is located at 1350 Avenue of the Americas, Suite 2600,
New York, NY 10019.

(7) Includes 169,574 shares of common stock and 511,179 options to purchase shares of common stock that may be sold under this prospectus,
as well as 140,227 additional options to purchase shares of common stock that are exercisable within 60 days. Mr. Ceppi previously
served as Chief Technology Officer of the Company.

(8) Represents 200,226 shares of common stock held by Chardan
Healthcare Investments LLC. The business address for Chardan Healthcare Investments LLC is c/o Chardan Capital Markets LLC, 17 State
Street, 21 st Floor, New York, NY 10004.

(9) Represents 1,000,000 PIPE shares held by Citadel CEMF Investments Ltd. ("CEMF"). Citadel Advisors LLC ("Citadel
Advisors") is the portfolio manager of CEMF. Citadel Advisors Holdings LP ("CAH") is the sole member of Citadel Advisors.
Citadel GP LLC ("CGP") is the general partner of CAH. Kenneth Griffin owns a controlling interest in CGP. Mr. Griffin,
as the owner of a controlling interest in CGP, may be deemed to have shared power to vote and/or shared power to dispose of the securities
held by CEMF. This disclosure shall not be construed as an admission that Mr. Griffin or any of the Citadel related entities listed
above is the beneficial owner of any securities of the Company other than the securities actually owned by such person (if any). The business
address of Citadel CEMF Investments Ltd. is c/o Citadel Advisors LLC, 601 Lexington Avenue, New York, NY 10022.

(10) Includes 726,137 shares of common stock and 3,848,549 options to purchase shares of common stock that may be sold under this prospectus,
as well as 542,316 additional options to purchase shares of common stock that are exercisable within 60 days. Mr. Coman is the Chief
Executive Officer and a director of the Company.

(11) Includes 686,768 shares of common stock and 158,844 options to purchase shares of common stock that may be sold under this prospectus,
as well as 228,703 additional options to purchase shares of common stock that are exercisable within 60 days. Mr. Cotliar is the
Chief Medical Officer of the Company.

(12) Represents 100,000 PIPE shares held by FMB Research LLC.
Franklin M. Berger is the sole member of FMB Research LLC and may be deemed to have beneficial ownership of the shares. Mr. Berger
disclaims beneficial ownership of the shares except to the extent of his pecuniary interest therein. FMB Research LLC is located at 257 Park
Avenue South, 15 th Floor, New York, NY 10010.

(13) Includes 110,456 shares of common stock and 297,829 options to purchase shares of common stock that may be sold under this prospectus,
as well as 448,887 additional options to purchase shares of common stock that are exercisable within 60 days. Ms. Forman is the Chief
Delivery Officer of the Company.

(14) Includes 914,937 options to purchase shares of common stock that may be sold under this prospectus, as well as 447,611 additional
options to purchase shares of common stock that are exercisable within 60 days. Mr. Geffon is the former Chief Commercial Officer
of the Company and serves as a strategic advisor to the Company's Chief Executive Officer.

(15) Includes 403,906 options to purchase shares of common stock that may be sold under this prospectus, as well as 27,575 additional options
to purchase shares of common stock that are exercisable within 60 days. Mr. Hubbard is a member of the board of directors of the
Company.

(16) Includes (a) 1 share of common stock owned by the Sponsor and (b) 1,945,896 shares of common stock owned by LifeSci Ventures
Partners II, LP, including 100,000 PIPE shares. Michael Rice and Andrew McDonald are the managing members of the Sponsor and the general
partners of LifeSci Ventures Partners II, LP. The address for these entities and individuals is c/o Science 37 Holdings, Inc., 800
Park Offices Drive, Suite 3606, Research Triangle Park, North Carolina 27709.

(17) Mr. Dobkin was the Chief Financial Officer and served on the board of directors of the Company prior to the Closing.

(18) Mr. Rice was our Chief Operating Officer and served on our board of directors prior to the Closing.

(19) Mr. McDonald was our Chief Executive Officer and served on our board of directors prior to the Closing.

(20) Includes (a) 3,505,890 shares of common stock held by Lux Co-Invest Opportunities, L.P., including 300,000 PIPE shares, and (b) 8,743,999
shares of common stock held by Lux Ventures IV, L.P. Lux Co-Invest Partners, LLC is the general partner of Lux Co-Invest Opportunities,
L.P. and exercises voting and dispositive power over the shares held by Lux Co-Invest Opportunities, L.P. Lux Venture Partners IV, LLC
is the general partner of Lux Ventures IV, L.P. and exercises voting and dispositive power over the shares held by Lux Ventures IV, L.P.
Peter Hebert and Joshua Wolfe are the individual managing members of Lux Venture Partners IV, LLC and Lux Co-Invest Partners, LLC (the
 "Individual Lux Managers"). The Individual Lux Managers, as the sole managers of Lux Venture Partners IV, LLC and Lux Co-Invest
Partners, LLC, may be deemed to share voting and dispositive power for the shares held by Lux Ventures IV, L.P. and Lux Co-Invest Opportunities,
L.P. Each of Lux Venture Partners IV, LLC, Lux Co-Invest Partners, LLC and the Individual Lux Managers separately disclaims beneficial
ownership over the shares noted herein except to the extent of their pecuniary interest therein. The address for these entities and individuals
is c/o Lux Capital Management, 920 Broadway, 11th Floor, New York, NY 10010.

(21) Includes 500,000 PIPE shares held by MDC Capital Partners (Ventures) LP. MDC Capital Partners (Ventures) GP, LP is the general partner
of MDC Capital Partners (Ventures) LP. MDC Capital Partners (Ventures) GP, LP has created an investment committee comprised of individual
members, which has the authority, by affirmative majority consent, to approve all investment and divestment decisions made with respect
to MDC Capital Partners (Ventures) LP. Each of the members of the investment committee expressly disclaims beneficial ownership of the
shares held by MDC Capital Partners (Ventures) LP. The address of the entities listed herein is c/o Mubadala Capital, 22nd Floor,
Al Sila Tower, Abu Dhabi Global Market, Al Maryah Island, Abu Dhabi, UAE.

(22) Includes 250,000 PIPE shares held by Novartis Pharma AG. The business address for Novartis Pharma AG is Lichstrasse 35, Basel, Switzerland
4056. (23) Represents 1,500,000 PIPE shares held by Perceptive Life Sciences Master Fund, Ltd. Perceptive Advisors, LLC serves as the investment
advisor to Perceptive Life Sciences Master Fund, Ltd. Joseph Edelman is the managing member of Perceptive Advisors, LLC, and disclaims
beneficial ownership over the shares except to the extent of his pecuniary interest therein. The address of Perceptive Life Sciences Master
Fund, Ltd. is c/o Perceptive Advisors, LLC, 51 Astor Place, 10th Floor, New York, New York 10003.

(24) Includes 1,270,739 options to purchase shares of common stock that may be sold under this prospectus, as well as 182,466 additional
options to purchase shares of common stock that are exercisable within 60 days. Ms. Pellizzari is the Chief Legal and Human Resources
Officer of the Company.

(25) Includes 500,000 PIPE shares held by Pharmaceutical Product Development, LLC. Wildcat Acquisition Holdings (UK) Limited ("Wildcat")
is the sole member of Pharmaceutical Product Development, LLC; Jaguar Holding Company II ("Jaguar II") is the sole shareholder
of Wildcat; Jaguar Holding Company I, LLC ("Jaguar I") is the sole shareholder of Jaguar II; Eagle Holding Company II, LLC
("Eagle II") is the sole member of Jaguar I; PPD, Inc. ("PPD") is the sole member of Eagle II; Thermo Fisher
Scientific Powder US Holdings Corp. ("Powder Holdings") is the sole shareholder of PPD; and Thermo Fisher Scientific Inc.
("Thermo Fisher"), a Delaware corporation, is the ultimate parent entity of Powder Holdings. By virtue of such relationships,
each may be deemed to have beneficial ownership over such securities, and each disclaim beneficial ownership of such securities, except
to the extent of its or their pecuniary interest therein, if any. The principal office of Wildcat is 11 Granta Park, Cambridge CB21 6GQ,
United Kingdom, the principal office of each of PPD, Eagle II, Jaguar I, Jaguar II and Pharma LLC is 929 North Front Street, Wilmington,
North Carolina 28401 and the principal office of each of Thermo Fisher and Powder Holdings is 168 Third Avenue, Waltham, Massachusetts
02451. (26) Includes (i) 43,000 PIPE shares held by Sea Hawk Multi-Strategy Master Fund Ltd; (ii) 43,000 PIPE Shares held by Walleye
Manager Opportunities LLC; (iii) 6,400 common shares and 64,000 PIPE Shares held by Walleye Opportunities Master Fund Ltd (collectively,
the "Managed Accounts"); (iv) 241,000 PIPE Shares held by Highmark Limited, in respect of its Segregated Account
Highmark Long/Short Equity 20 (the "Additional Managed Account"); and (v) 609,000 PIPE Shares held by Pura Vida Master
Fund Ltd. (the "PV Fund"). Pura Vida Investments, LLC ("PVI") serves as the sub-adviser to the Managed Accounts
and the investment manager to the Additional Managed Account and the PV Fund. Efrem Kamen serves as the managing member of PVI. By virtue
of these relationships, PVI and Efrem Kamen may be deemed to have shared voting and dispositive power with respect to the PIPE Shares
held by the Managed Accounts, the Additional Managed Account, and the PV Fund. This report shall not be deemed an admission that PVI and/or
Efrem Kamen are beneficial owners of the PIPE Shares for purposes of Section 13 of the Securities Exchange Act of 1934, as amended,
or for any other purpose. Each of PVI and Efrem Kamen disclaims beneficial ownership of the PIPE Shares reported herein except to the
extent of each PVI's and Efrem Kamen's pecuniary interest therein. The business address of Pura Vida Investments, LLC is 512
West 22nd Street, 7th Floor, New York, NY 10011.

(27) Includes (a) 467,380 shares of common stock held by RAF, L.P., (b) 7,252,571 shares of common stock held by Redmile Private
Investments II, L.P., (c) 616,055 shares of common stock held by Redmile Strategic Master Fund, LP, and (d) 11,472,228 shares
of common stock, including 5,000,000 PIPE shares, held by RedCo II Master Fund, L.P. Redmile Group, LLC is the investment manager/adviser
to each of the private investment vehicles listed in items (a) through (d) (collectively, the "Redmile Funds") and,
in such capacity, exercises voting and investment power over all of the securities held by the Redmile Funds and may be deemed to be the
beneficial owner of these securities. Jeremy C. Green serves as the managing member of Redmile Group, LLC and also may be deemed to be
the beneficial owner of these shares. Redmile Group, LLC, Mr. Green and Robert Faulkner each disclaim beneficial ownership of these
shares, except to the extent of its or his pecuniary interest in such shares, if any. Mr. Faulkner is a member of the board of directors
of the Company and was designated by certain affiliates of Redmile Group, LLC pursuant to a Director Nomination Agreement, dated October 6,
2021, between the Company and certain other parties. Also includes 41,363 options to purchase shares of common stock exercisable within
60 days held by Mr. Faulkner. Pursuant to the internal policies of Redmile Group, LLC, Mr. Faulkner holds these options as a
nominee on behalf, and for the sole benefit, of Redmile Group, LLC and has assigned all economic, pecuniary and voting rights in respect
of the stock options to Redmile Group, LLC. The address of the Redmile Funds, Mr. Green and Mr. Faulkner is c/o Redmile Group,
LLC, One Letterman Dr., Building D, Suite D3-300, San Francisco, CA 94129.

(28) Includes (a) 59,567 PIPE shares held by RTW Venture Fund Limited; (b) 1,972,565 PIPE shares held by RTW Master Fund, LTD.;
and (c) 967,868 PIPE shares held by RTW Innovation Master Fund, LTD. The registered holders of the referenced shares are funds
under management by RTW Investments, LP. Roderick Wong, M.D. is the Managing Partner of RTW Investments, LP, and has voting and investment
power over the shares held by the funds, which are the registered holders of the referenced shares. Mr. Wong disclaims beneficial
ownership of the shares held by the funds, except to the extent of his pecuniary interest therein. The address of such funds and such
portfolio managers is 40 10th Avenue, Floor 7, New York, New York 10014.

(29) Represents 800,000 PIPE shares held by Samsara BioCapital, L.P. ("Samsara LP"). Samsara BioCapital GP, LLC ("Samsara
LLC") is the general partner of Samsara LP and may be deemed to beneficially own the shares held by Samsara LP. Dr. Srinivas
Akkaraju, M.D., Ph.D., has voting and investment power over the shares held by Samsara LP and, accordingly, may be deemed to beneficially
own the shares held by Samsara LP. Each of Samsara LLC and Dr. Akkaraju disclaims beneficial ownership of these shares except to
the extent of his or its respective pecuniary interest therein. The address of Samsara LP is 628 Middlefield Road, Palo Alto, CA 94301.

(30) Represents 1,200,000 PIPE shares held by Velan Capital Partners LP. Velan Capital Investment Management LP, the investment manager
of Velan Capital Partners LP, has voting and investment control of the shares held by Velan Capital Partners LP. Balaji Venkataraman is
the Managing Partner of Velan Capital Investment Management LP and may be deemed to be the beneficial owner of such shares. Mr. Venkataraman
disclaims any beneficial ownership of the shares held by Velan Capital Partners LP, except to the extent of his pecuniary interest therein.
The registered address of Velan Capital Partners LP is at 1055 Powers Place, Suite B, Alpharetta, GA 30009.

(31) Represents 178,320 PIPE shares held by Victory RS Science and Technology Fund (the "Fund"). Victory Capital Investment
Management Inc. ("Victory Capital") serves as the investment adviser to the Fund. Victory Capital is an indirect wholly owned
subsidiary of Victory Capital Holdings, Inc., a publicly traded company with its principal address at 15935 La Cantera Parkway, San
Antonio, TX 78256. By delegation from the Fund and its Board of Trustees, Victory Capital has the power to dispose of the securities acting
through members of its investment franchise, RS Investments Growth, and to vote the securities in accordance with its proxy voting policy
through its proxy committee, which is composed of eight individuals. The address for the Fund is c/o Victory Capital Management Inc.,
4900 Tiedeman Road, 4th Floor, Brooklyn, OH 44144.

(32) Represents 621,680 PIPE shares held by Victory USAA Science & Technology Fund (the "USAA Fund"). Victory Capital
serves as the investment adviser to the USAA Fund. Victory Capital is an indirect wholly owned subsidiary of Victory Capital Holdings, Inc.,
a publicly traded company with its principal address at 15935 La Cantera Parkway, San Antonio, TX, 78256. By delegation from the USAA
Fund and its Board of Trustees, Victory Capital has the power to dispose of the securities acting through members of its investment franchise,
RS Investments Growth, and to vote the securities in accordance with its proxy voting policy through its proxy committee, which is composed
of eight individuals. The address for the USAA Fund is c/o Victory Capital Management Inc., 4900 Tiedeman Road, 4th Floor, Brooklyn,
OH 44144.

(33) Includes 1,372,403 options to purchase shares of common stock that may be sold under this prospectus, as well as 233,348 additional
options to purchase shares of common stock that are exercisable within 60 days. Mr. Zaranek is the Chief Financial Officer of the
Company.

**PLAN OF DISTRIBUTION**

The Selling Securityholders, which as used herein includes donees, pledgees, transferees, distributees or other successors-in-interest selling shares of our common stock or interests in our common stock received after the date of this prospectus from the Selling Securityholders as a gift, pledge, partnership distribution or other transfer, may, from time to time, sell, transfer, distribute or otherwise dispose of certain of their shares of common stock or interests in our common stock on any stock exchange, market or trading facility on which shares of our common stock are traded or in private transactions. These dispositions may be at fixed prices, at prevailing market prices at the time of sale, at prices related to the prevailing market price, at varying prices determined at the time of sale, or at negotiated prices.

The Selling Securityholders may use any one or more of the following methods when disposing of their shares of common stock or interests therein:

&nbsp;&nbsp;&nbsp;&nbsp;• purchases by a broker-dealer as principal and resale by such broker-dealer for its own account pursuant to this prospectus;

&nbsp;&nbsp;&nbsp;&nbsp;• ordinary brokerage transactions and transactions in which the broker solicits purchasers;

&nbsp;&nbsp;&nbsp;&nbsp;• block trades in which the broker-dealer so engaged will attempt to sell the shares as agent but may position and resell a portion
of the block as principal to facilitate the transaction;

&nbsp;&nbsp;&nbsp;&nbsp;• in the over-the-counter market;

&nbsp;&nbsp;&nbsp;&nbsp;• through trading plans entered into by a Selling Securityholder pursuant to Rule 10b5-1 under the Exchange Act, that are in place
at the time of an offering pursuant to this prospectus and any applicable prospectus supplement hereto that provide for periodic sales
of their securities on the basis of parameters described in such trading plans;

&nbsp;&nbsp;&nbsp;&nbsp;• to or through underwriters or broker-dealers;

&nbsp;&nbsp;&nbsp;&nbsp;• in "at the market" offerings, as defined in Rule 415 under the Securities Act, at negotiated prices, at prices prevailing
at the time of sale or at prices related to such prevailing market prices, including sales made directly on a national securities exchange
or sales made through a market maker other than on an exchange or other similar offerings through sales agents;

&nbsp;&nbsp;&nbsp;&nbsp;• in transactions otherwise than on these exchanges or systems or in the over-the-counter market;

&nbsp;&nbsp;&nbsp;&nbsp;• in privately negotiated transactions;

&nbsp;&nbsp;&nbsp;&nbsp;• through the writing or settlement of options or other hedging transactions, whether such options are listed on an options exchange
or otherwise;

&nbsp;&nbsp;&nbsp;&nbsp;• in short sales or in settlement of short sales entered into after the effective date of the registration statement of which this prospectus
is part;

&nbsp;&nbsp;&nbsp;&nbsp;• through the distribution or transfer of the shares of common stock or interests therein by any Selling Stockholder to its partners,
members or stockholders;

&nbsp;&nbsp;&nbsp;&nbsp;• pursuant to agreements or arrangements with broker-dealers to sell a specified number of such shares at a stipulated price per share;

&nbsp;&nbsp;&nbsp;&nbsp;• directly to one or more purchasers;

&nbsp;&nbsp;&nbsp;&nbsp;• through delayed delivery requirements;

&nbsp;&nbsp;&nbsp;&nbsp;• by pledge to secured debts and other obligations;

&nbsp;&nbsp;&nbsp;&nbsp;• through a combination of any of the above methods of sale; or

&nbsp;&nbsp;&nbsp;&nbsp;• any other method permitted pursuant to applicable law.

In addition, the Selling Securityholders may also sell securities under Rule 144 under the Securities Act, if available, or in other transactions exempt from registration, rather than under this prospectus.

In addition, a Selling Securityholder that is an entity may elect to make a pro rata in-kind distribution of securities to its members, partners or stockholders pursuant to the registration statement of which this prospectus is a part by delivering a prospectus with a plan of distribution. Such members, partners or stockholders would thereby receive freely tradeable securities pursuant to the distribution through a registration statement. To the extent a distributee is an affiliate of ours (or to the extent otherwise required by law), we may, at our option, file a prospectus supplement in order to permit the distributees to use the prospectus to resell the securities acquired in the distribution.

To the extent required, this prospectus may be amended or supplemented from time to time to describe a specific plan of distribution. In connection with distributions of the shares or otherwise, the Selling Securityholders may enter into hedging transactions with broker-dealers or other financial institutions. In connection with such transactions, broker-dealers or other financial institutions may engage in short sales of shares of common stock in the course of hedging the positions they assume with Selling Securityholders. The Selling Securityholders may also sell shares of common stock short and redeliver the shares to close out such short positions. The Selling Securityholders may also enter into option or other transactions with broker-dealers or other financial institutions that require the delivery to such broker-dealer or other financial institution of shares offered by this prospectus, which shares such broker-dealer or other financial institution may resell pursuant to this prospectus (as supplemented or amended to reflect such transaction). The Selling Securityholders may also pledge shares to a broker-dealer or other financial institution, and, upon a default, such broker-dealer or other financial institution may effect sales of the pledged shares pursuant to this prospectus (as supplemented or amended to reflect such transaction).

A Selling Securityholder may enter into derivative transactions with third parties, or sell securities not covered by this prospectus to third parties in privately negotiated transactions. If the applicable prospectus supplement indicates, in connection with those derivatives, the third parties may sell securities covered by this prospectus and the applicable prospectus supplement, including in short sale transactions. If so, the third party may use securities pledged by any Selling Securityholder or borrowed from any Selling Securityholder or others to settle those sales or to close out any related open borrowings of stock, and may use securities received from any Selling Securityholder in settlement of those derivatives to close out any related open borrowings of stock. The third party in such sale transactions will be an underwriter and will be identified in the applicable prospectus supplement (or a post-effective amendment). In addition, any Selling Securityholder may otherwise loan or pledge securities to a financial institution or other third party that in turn may sell the securities short using this prospectus. Such financial institution or other third party may transfer its economic short position to investors in our securities or in connection with a concurrent offering of other securities.

In effecting sales, broker-dealers or agents engaged by the Selling Securityholders may arrange for other broker-dealers to participate. Broker-dealers or agents may receive commissions, discounts or concessions from the Selling Securityholders in amounts to be negotiated immediately prior to the sale.

In offering the shares covered by this prospectus, the Selling Securityholders and any broker-dealers who execute sales for the Selling Securityholders may be deemed to be "underwriters" within the meaning of the Securities Act in connection with such sales (it being understood that the Selling Securityholders shall not be deemed to be underwriters solely as a result of their participation in this offering). Any profits realized by the Selling Securityholders and the compensation of any broker-dealer may be deemed to be underwriting discounts and commissions.

In order to comply with the securities laws of certain states, if applicable, the shares must be sold in such jurisdictions only through registered or licensed brokers or dealers. In addition, in certain states the shares may not be sold unless they have been registered or qualified for sale in the applicable state or an exemption from the registration or qualification requirement is available and is complied with.

We have advised the Selling Securityholders that the anti-manipulation rules of Regulation M under the Exchange Act may apply to sales of shares in the market and to the activities of the Selling Securityholders and their affiliates. In addition, we will make copies of this prospectus available to the Selling Securityholders for the purpose of satisfying the prospectus delivery requirements of the Securities Act. The Selling Securityholders may indemnify any broker-dealer that participates in transactions involving the sale of the shares against certain liabilities, including liabilities arising under the Securities Act.

At the time a particular offer of shares is made, if required, a prospectus supplement will be distributed that will set forth the number of shares being offered and the terms of the offering, including the name of any underwriter, dealer or agent, the purchase price paid by any underwriter, any discount, commission and other item constituting compensation, any discount, commission or concession allowed or reallowed or paid to any dealer, and the proposed selling price to the public.

We have agreed to indemnify the Selling Securityholders against certain liabilities, including certain liabilities under the Securities Act, relating to the registration of the shares offered by this prospectus.

**LEGAL MATTERS**

The validity of the shares of common stock offered hereby has been passed upon for us by Thompson Hine LLP.

**EXPERTS**

The consolidated financial statements of Science 37 Holdings, Inc. appearing in Science 37 Holdings, Inc.'s Annual Report (Form 10-K) for the year ended December 31, 2022, have been audited by Ernst & Young LLP, independent registered public accounting firm, as set forth in their report thereon, included therein, and incorporated herein by reference. Such consolidated financial statements are incorporated herein by reference in reliance upon such report given on the authority of such firm as experts in accounting and auditing.

![](tm238343d1_posamimg002.jpg)

**Science 37 Holdings, Inc.**

**103,576,231 Shares of Common Stock**

**_____________________**

**PROSPECTUS**

**_____________________**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**, 2023**

**PART II**

**INFORMATION NOT REQUIRED IN PROSPECTUS**

**Item 14. Other Expenses of Issuance and Distribution.**

The following table indicates the expenses to be incurred in connection with the offering described in this registration statement, other than underwriting discounts and commissions.

---

| | |
|:---|:---|
|  | **Amount** |
| Securities and Exchange Commission registration fee | $106336.80<sup>(1)</sup> |
| FINRA filing fee | \* |
| Accountants' fees and expenses | \* |
| Legal fees and expenses | \* |
| Blue Sky fees and expenses | \* |
| Transfer Agent's fees and expenses | \* |
| Printing and engraving expenses | \* |
| Miscellaneous | \* |
| Total expenses | $\* |

---

\* Omitted because estimates are not currently available. The expenses of any offering will be set forth in the applicable prospectus supplement.

(1) Previously paid.

**Item 15. Indemnification of Directors and Officers.**

Section 102 of the General Corporation Law of the State of Delaware permits a corporation to eliminate the personal liability of directors of a corporation to the corporation or its stockholders for monetary damages for a breach of fiduciary duty as a director, except where the director breached his duty of loyalty, failed to act in good faith, engaged in intentional misconduct or knowingly violated a law, authorized the payment of a dividend or approved a stock repurchase in violation of Delaware corporate law or obtained an improper personal benefit. Our certificate of incorporation provides that no director of the Company shall be personally liable to it or its stockholders for monetary damages for any breach of fiduciary duty as a director, notwithstanding any provision of law imposing such liability, except to the extent that the General Corporation Law of the State of Delaware prohibits the elimination or limitation of liability of directors for breaches of fiduciary duty.

Section 145 of the General Corporation Law of the State of Delaware provides that a corporation has the power to indemnify a director, officer, employee, or agent of the corporation, or a person serving in such role at the request of the corporation for another corporation, partnership, joint venture, trust or other enterprise in related capacities against expenses (including attorneys' fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by the person in connection with an action, suit or proceeding to which he or she was or is a party or is threatened to be made a party to any threatened, pending or completed action, suit or proceeding by reason of such position, if such person acted in good faith and in a manner he or she reasonably believed to be in or not opposed to the best interests of the corporation, and, in any criminal action or proceeding, had no reasonable cause to believe his or her conduct was unlawful, except that, in the case of actions brought by or in the right of the corporation, no indemnification shall be made with respect to any claim, issue or matter as to which such person shall have been adjudged to be liable to the corporation unless and only to the extent that the Court of Chancery or other adjudicating court determines that, despite the adjudication of liability but in view of all of the circumstances of the case, such person is fairly and reasonably entitled to indemnity for such expenses which the Court of Chancery or such other court shall deem proper.

Our bylaws provide that we will indemnify and hold harmless, to the fullest extent permitted by the General Corporation Law of the State of Delaware, each person who was or is a party or threatened to be made a party to any threatened, pending or completed action, suit or proceeding (other than an action by or in the right of us) by reason of the fact that such person is or was a director or officer, or is or was serving at our request as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or enterprise (all such persons being referred to as an "Indemnitee"), against all expenses (including attorneys' fees), judgments, fines and amounts paid in settlement actually and reasonably incurred in connection with such action, suit or proceeding, if such Indemnitee acted in good faith and in a manner such Indemnitee reasonably believed to be in, or not opposed to, our best interests, and, with respect to any criminal action or proceeding, such Indemnitee had no reasonable cause to believe such Indemnitee's conduct was unlawful. Our bylaws provide that we will indemnify any Indemnitee who was or is a party or threatened to be made a party to any threatened, pending or completed action or suit by or in the right of us to procure a judgment in our favor by reason of the fact that the Indemnitee is or was a director or officer, or is or was serving at our request as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or enterprise, against all expenses (including attorneys' fees) actually and reasonably incurred in connection with such action or suit, if the Indemnitee acted in good faith and in a manner such Indemnitee reasonably believed to be in, or not opposed to, our best interests, except that no indemnification shall be made with respect to any claim, issue or matter as to which such Indemnitee shall have been adjudged to be liable to us, unless a court determines that, despite such adjudication but in view of all of the circumstances, such Indemnitee is entitled to indemnification of such expenses. Expenses must be advanced to an Indemnitee under certain circumstances.

We have entered into indemnification agreements with each of our directors and officers. These indemnification agreements may require us, among other things, to indemnify our directors and officers for some expenses, including attorneys' fees, judgments, fines and settlement amounts incurred by a director or officer in any action or proceeding arising out of his or her service as one of our directors or officers, or any of our subsidiaries or any other company or enterprise to which the person provides services at our request.

We maintain a general liability insurance policy that covers certain liabilities of directors and officers of the Company arising out of claims based on acts or omissions in their capacities as directors or officers.

**Item 16. Exhibits and Financial Statement Schedules.**

---

| | | | | |
|:---|:---|:---|:---|:---|
| | | **Incorporated by Reference** | **Incorporated by Reference** | **Incorporated by Reference** |
| **Exhibit**<br>**Number** | <br>**Description** | **Form** | **Exhibit** | **Filing Date** |
| 2.1# | [Agreement and Plan of Merger, dated as of May 6, 2021, by and among LifeSci Acquisition II Corp., LifeSci Acquisition II Merger Sub, Inc. and Science 37, Inc.](https://www.sec.gov/Archives/edgar/data/1819113/000110465921062780/tm2115351d1_ex2-1.htm) | 8-K | 2.1 | May 7, 2021 |
| 3.1 | [Second Amended and Restated Certificate of Incorporation](https://www.sec.gov/Archives/edgar/data/1819113/000110465921135047/snce-20211105xex3d1.htm) | S-1 (File No. 333-260828) | 3.1 | November 5, 2021 |
| 3.2 | [Amended and Restated Bylaws of Science 37 Holdings, Inc.](https://www.sec.gov/Archives/edgar/data/1819113/000110465921125878/tm2129820d1_ex3-3.htm) | 8-K | 3.3 | October 13, 2021 |
| 4.1 | [Form of PIPE Subscription Agreement, dated May 6, 2021](https://www.sec.gov/Archives/edgar/data/1819113/000110465921062780/tm2115351d1_ex10-3.htm) | 8-K | 10.3 | May 7, 2021 |
| 4.2 | [Amended and Restated Registration Rights Agreement, dated October 6, 2021, by and among the Company and certain stockholders](https://www.sec.gov/Archives/edgar/data/1819113/000110465921135047/snce-20211105xex10d17.htm) | S-1 (File No. 333-260828) | 10.17 | November 5, 2021 |
| 5.1 | [Opinion of Thompson Hine LLP.](tm238343d1_ex5-1.htm) |  |  | \* |
| 23.1 | [Consent of Independent Registered Public Accounting Firm](tm238343d1_ex23-1.htm) |  |  | \* |
| 23.2 | [Consent of Thompson Hine LLP (included in Exhibit 5.1)](tm238343d1_ex5-1.htm) |  |  | \* |
| 24.1 | [Power of Attorney (included on signature page of the initial filing of this Registration Statement)](https://www.sec.gov/ix?doc=/Archives/edgar/data/1819113/000110465921135047/snce-20211105xs1.htm#SIGNATURESANDPOWEROFATTORNEY_472251) | S-1 (File No. 333-260828) | 24.1 | November 5, 2021 |
| 24.2 | [Power of Attorney of Paul von Autenried](tm238343d1_ex24-2.htm) |  |  | \* |

---

\* Filed herewith. 

# Certain of the exhibits and schedules to this Exhibit have been omitted in accordance with Regulation S-K Item 601(a)(5). The Company agrees to furnish a copy of all omitted exhibits and schedules to the SEC upon its request.

**Item 17. Undertakings.**

(a) The undersigned registrant hereby undertakes:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) To include any prospectus required by Section 10(a)(3) of the Securities Act of 1933;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent
post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth
in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar
value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum
offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate,
the changes in volume and price represent no more than 20 percent change in the maximum aggregate offering price set forth in the "Calculation
of Registration Fee" table in the effective registration statement; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement
or any material change to such information in the registration statement;

*provided, however*, that paragraphs (a)(1)(i), (ii), and (iii) above do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the SEC by the registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in the registration statement, or is contained in a form of prospectus filed pursuant to Rule 424(b) that is part of the registration statement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed
to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall
be deemed to be the initial bona fide offering thereof.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the
termination of the offering.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(4) That, for the purpose of determining liability under the Securities Act of 1933 to any purchaser:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) Each prospectus filed by the registrant pursuant to Rule 424(b)(3) shall be deemed to be part of the registration statement
as of the date the filed prospectus was deemed part of and included in the registration statement; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) Each prospectus required to be filed pursuant to Rule 424(b)(2), (b)(5), or (b)(7) as part of a registration statement in
reliance on Rule 430B relating to an offering made pursuant to Rule 415(a)(1)(i), (vii), or (x) for the purpose of providing
the information required by Section 10(a) of the Securities Act shall be deemed to be part of and included in the registration
statement as of the earlier of the date such form of prospectus is first used after effectiveness or the date of the first contract of
sale of securities in the offering described in the prospectus. As provided in Rule 430B, for liability purposes of the issuer and
any person that is at that date an underwriter, such date shall be deemed to be a new effective date of the registration statement relating
to the securities in the registration statement to which that prospectus relates, and the offering of such securities at that time shall
be deemed to be the initial bona fide offering thereof. *Provided, however*, that no statement made in a registration statement or
prospectus that is part of the registration statement or made in a document incorporated or deemed incorporated by reference into the
registration statement or prospectus that is part of the registration statement will, as to a purchaser with a time of contract of sale
prior to such effective date, supersede or modify any statement that was made in the registration statement or prospectus that was part
of the registration statement or made in any such document immediately prior to such effective date.

(b) The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing
of the registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where
applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that
is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities
offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

(h) Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling
persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the
SEC such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that
a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director,
officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director,
officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel
the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification
by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.

**SIGNATURES**

Pursuant to the requirements of the Securities Act, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and has duly caused this post-effective amendment to the Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Research Triangle Park, State of North Carolina, on March 6, 2023.

---

| | | |
|:---|:---|:---|
| **SCIENCE 37 HOLDINGS, INC.** | **SCIENCE 37 HOLDINGS, INC.** | **SCIENCE 37 HOLDINGS, INC.** |
| By: | /s/ David Coman | /s/ David Coman |
|  | Name: | David Coman |
|  | Title: | Chief Executive Officer |

---

Pursuant to the requirements of the Securities Act, this post-effective amendment to the Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

---

| | | |
|:---|:---|:---|
| **Signature** | **Title** | **Date** |
| /s/ David Coman | Chief Executive Officer and Director<br> *(Principal Executive Officer)* | March 6, 2023 |
| David Coman | Chief Executive Officer and Director<br> *(Principal Executive Officer)* | March 6, 2023 |
| /s/ Mike Zaranek | Chief Financial Officer *(Principal Financial Officer and Principal Accounting Officer)* | March 6, 2023 |
| Mike Zaranek | Chief Financial Officer *(Principal Financial Officer and Principal Accounting Officer)* | March 6, 2023 |
| \* | Director | March 6, 2023 |
| Robert Faulkner | Director | March 6, 2023 |
| \* | Director | March 6, 2023 |
| Bhooshitha B. De Silva | Director | March 6, 2023 |
| \* | Director | March 6, 2023 |
| John W. Hubbard | Director | March 6, 2023 |
| \* | Director | March 6, 2023 |
| Emily Rollins | Director | March 6, 2023 |
| \* | Director | March 6, 2023 |
| Neil Tiwari | Director | March 6, 2023 |
| \* | Director | March 6, 2023 |
| Paul von Autenried | Director | March 6, 2023 |

---

---

| | |
|:---|:---|
| \*By: | /s/ David Coman |
|  | David Coman |
|  | Attorney-in-Fact |

---

## Exhibit 5.1

**Exhibit 5.1**

![](tm238343d1_ex5-1img001.jpg)

March 6, 2023

Science 37 Holdings, Inc.

800 Park Offices Drive, Suite 3606

Research Triangle Park, North Carolina 27709

Re: Post-Effective Amendment on Form S-3

Ladies and Gentlemen:

We have acted as counsel to Science 37 Holdings, Inc., a Delaware corporation (the "<u>Company</u>"), in connection with the Registration Statement on Form S-3 (File No. 333-260828) (the "<u>Registration Statement</u>"), filed on the date hereof with the Securities and Exchange Commission (the "<u>Commission</u>") under the Securities Act of 1933, as amended, relating to the proposed resale of up to 103,576,231 shares (the "<u>Selling Holder Shares</u>") of common stock, par value $0.0001 per share, of the Company, which includes (i) up to 12,500,000 shares of common stock (the "<u>Earn-out Shares</u>") that certain Company stockholders have the contingent right to receive upon the achievement of certain stock price-based vesting conditions pursuant to that certain Agreement and Plan of Merger, dated as of May 6, 2021, by and among the Company (f/k/a LifeSci Acquisition II Corp.), LifeSci Acquisition II Merger Sub, Inc. and Science 37, Inc. (the "<u>Merger Agreement</u>") and (ii) up to 8,949,597 shares of common stock reserved for issuance (the "<u>Option Shares</u>") upon the exercise of outstanding options to purchase shares of common stock (the "<u>Options</u>"), pursuant to the applicable option agreements (each, an "<u>Option Agreement</u>"), by the selling stockholders listed in the Registration Statement, all of which Selling Holder Shares may be sold from time to time and on a delayed or continuous basis, as described in the prospectus that forms a part of the Registration Statement (the "<u>Prospectus</u>").

In rendering this opinion, we have examined copies of (a) the Company's Second Amended and Restated Certificate of Incorporation, (b) the Company's Amended and Restated Bylaws, (c) the Registration Statement and Prospectus, (d) the Merger Agreement, and (e) copies of such other agreements, documents, instruments, and records as we have deemed advisable in order to render our opinion set forth below. In such examination, we have assumed the genuineness of all signatures, the legal capacity of all natural persons, that all parties (other than the Company) had the requisite power and authority (corporate or otherwise) to execute, deliver and perform such agreements or instruments, that all such agreements or instruments have been duly authorized by all requisite action (corporate or otherwise), executed and delivered by such parties and that such agreements or instruments are valid, binding and enforceable obligations of such parties, the authenticity of all documents submitted to us as originals, the conformity to original documents of all documents submitted to us as certified, conformed or photostatic copies and the authenticity of the originals of such latter documents. In providing this opinion, we have further relied as to certain matters on information obtained from public officials and officers of the Company. For purposes of the opinions set forth in numbered paragraphs 2 and 3, we have assumed that, before the Earn-out Shares and Option Shares are issued, the Company will not issue shares of common stock or reduce the total number of shares of common stock that the Company is authorized to issue under its then-effective certificate of incorporation such that the number of unissued shares of common stock authorized under the certificate of incorporation is less than the number of the Earn-out Shares and Option Shares.

On the basis of the foregoing, and in reliance thereon, we are of the opinion that:

&nbsp;&nbsp;&nbsp;&nbsp;1. The Selling Holder Shares (excluding the Earn-out Shares and the Option Shares) have been duly authorized by all necessary corporate
action of the Company, and such Selling Holder Shares are validly issued, fully paid and non-assessable.

&nbsp;&nbsp;&nbsp;&nbsp;2. The Earn-out Shares have been duly authorized by all necessary corporate action of the Company and, when and if issued pursuant to
the terms of the Merger Agreement, will be validly issued, fully paid and non-assessable.

![](tm238343d1_ex5-1img002.jpg)

![](tm238343d1_ex5-1img003.jpg)

March 6, 2023

&nbsp;&nbsp;&nbsp;&nbsp;3. The Option Shares have been duly authorized by all necessary corporate action of the Company and, when and if issued upon exercise
of the Options in accordance with the terms of the Options and the applicable Option Agreement, will be validly issued, fully paid and
non-assessable.

Our opinions expressed above are limited to the Delaware General Corporation Law, as currently in effect, and we express no opinion as to the effect on the matters covered by this letter of the laws of any other jurisdiction. We express no opinion that the Company is obligated to issue Earn-out Shares under the Merger Agreement at any time. We express no opinion as to (a) any provision for liquidated damages, default interest, late charges, monetary penalties, make-whole premiums or other economic remedies to the extent such provisions are deemed to constitute a penalty, (b) consents to, or restrictions upon, governing law, jurisdiction, venue, arbitration, remedies or judicial relief, (c) waivers of rights or defenses, (d) any provision requiring the payment of attorneys' fees, where such payment is contrary to law or public policy, (e) the creation, validity, attachment, perfection or priority of any lien or security interest, (f) advance waivers of claims, defenses, rights granted by law or notice, opportunity for hearing, evidentiary requirements, statutes of limitation, trial by jury or at law or other procedural rights, (g) waivers of broadly or vaguely stated rights, (h) provisions for exclusivity, election or cumulation of rights or remedies, (i) provisions authorizing or validating conclusive or discretionary determinations, (j) grants of setoff rights, (k) proxies, powers and trusts, (l) provisions prohibiting, restricting or requiring consent to assignment or transfer of any right or property, (m) any provision to the extent it requires that a claim with respect to a security denominated in other than U.S. dollars (or a judgment in respect of such a claim) be converted into U.S. dollars at a rate of exchange at a particular date, to the extent applicable law otherwise provides, and (n) the severability, if invalid, of provisions to the foregoing effect.

We have assumed that (a) each Option Agreement has been duly authorized, executed and delivered by the parties thereto other than the Company, (b) each Option Agreement constitutes legally valid and binding obligations of the parties thereto other than the Company, enforceable against each of them in accordance with their respective terms and (c) the status of each Option Agreement as legally valid and binding obligations of the parties will not be affected by any (i) breaches of, or defaults under, agreements or instruments, (ii) violations of statutes, rules, regulations or court or governmental orders or (iii) failures to obtain required consents, approvals or authorizations from, or to make required registrations, declarations or filings with, governmental authorities.

Our opinions set forth above are subject to bankruptcy, insolvency, fraudulent transfer, reorganization, moratorium and other similar laws of general application affecting the rights and remedies of creditors and to general principles of equity.

This opinion letter is expressly limited to the matters set forth above, and we render no opinion, whether by implication or otherwise, as to any other matters relating to the Company, the Selling Holder Shares, the Registration Statement or the Prospectus.

We hereby consent to being named in the Registration Statement and in the Prospectus under the caption "Legal Matters" and to the use of this opinion for filing with said Registration Statement as Exhibit 5.1 thereto. In giving this consent, we do not hereby admit that we are within the category of persons whose consent is required under Section 7 of the Securities Act of 1933, as amended, or the rules and regulations of the Commission promulgated thereunder.

Very truly yours,

*/s/ Thompson Hine LLP*

Thompson Hine LLP

## Exhibit 23.1

**Exhibit 23.1**

**Consent of Independent Registered Public Accounting Firm**

We consent to the reference to our firm under the caption "Experts" in this Registration Statement (Form S-3 No. 333-260828) and related Prospectus of Science 37 Holdings, Inc. for the registration of up to 103,576,231 shares of common stock and to the incorporation by reference therein of our report dated March 6, 2023, with respect to the consolidated financial statements of Science 37 Holdings, Inc. included in its Annual Report (Form 10-K) for the year ended December 31, 2022, filed with the Securities and Exchange Commission.

/s/ Ernst and Young LLP

Los Angeles, California

March 6, 2023

## Exhibit 24.2

**Exhibit 24.2**

**POWER OF ATTORNEY**

The undersigned hereby constitutes and appoints David Coman and Mike Zaranek, and each of them singly (with full power to each of them to act alone), his true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution in each of them, for him and in his name, place and stead, and in any and all capacities, to sign any and all amendments (including post-effective amendments) to this registration statement (or any other registration statement for the same offering that is to be effective upon filing pursuant to Rule 462(b) under the Securities Act of 1933), and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite or necessary to be done in and about the premises, as full to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents or any of them, or their or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

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| | | |
|:---|:---|:---|
| **Signature** | **Title** | **Date** |
| /s/ Paul von Autenried | Director | March 6, 2023 |
| Paul von Autenried |  |  |

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