# EDGAR Filing Document

**Accession Number:** 0001535472
**File Stem:** 0001011438-26-000276
**Filing Date:** 2026-5
**Character Count:** 13003
**Document Hash:** 333d25feeaf5062bd776f4d5296a01fb
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001011438-26-000276.hdr.sgml**: 20260511

**ACCESSION NUMBER**: 0001011438-26-000276

**CONFORMED SUBMISSION TYPE**: 4

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20260507

**FILED AS OF DATE**: 20260511

**DATE AS OF CHANGE**: 20260511

**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Meister Keith A.
- **CENTRAL INDEX KEY:** 0001307631

**ORGANIZATION NAME:**

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-39482
- **FILM NUMBER:** 26965363

**MAIL ADDRESS:**
- **STREET 1:** C/O CORVEX MANAGEMENT LP
- **STREET 2:** 667 MADISON AVENUE
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10065

**FORMER NAME:**
- **FORMER CONFORMED NAME:** Meister Keith
- **DATE OF NAME CHANGE:** 20041102
**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Corvex Management LP
- **CENTRAL INDEX KEY:** 0001535472

**ORGANIZATION NAME:**
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-39482
- **FILM NUMBER:** 26965362

**BUSINESS ADDRESS:**
- **STREET 1:** 667 MADISON AVENUE
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10065
- **BUSINESS PHONE:** (212) 474 6700

**MAIL ADDRESS:**
- **STREET 1:** 667 MADISON AVENUE
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10065
**ISSUER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** GeneDx Holdings Corp.
- **CENTRAL INDEX KEY:** 0001818331
- **STANDARD INDUSTRIAL CLASSIFICATION:** SERVICES-HEALTH SERVICES [8000]
- **ORGANIZATION NAME:** 08 Industrial Applications and Services
- **EIN:** 851966622
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**BUSINESS ADDRESS:**
- **STREET 1:** 333 LUDLOW STREET
- **STREET 2:** NORTH TOWER, 6TH FLOOR
- **CITY:** STAMFORD
- **STATE:** CT
- **ZIP:** 06902
- **BUSINESS PHONE:** 888-729-1206

**MAIL ADDRESS:**
- **STREET 1:** 333 LUDLOW STREET
- **STREET 2:** NORTH TOWER, 6TH FLOOR
- **CITY:** STAMFORD
- **STATE:** CT
- **ZIP:** 06902

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Sema4 Holdings Corp.
- **DATE OF NAME CHANGE:** 20210721

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** CM Life Sciences, Inc.
- **DATE OF NAME CHANGE:** 20200715

### UNITED STATES SECURITIES AND EXCHANGE COMMISSION
**Washington, D.C. 20549**

## FORM 4

### STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

[ ] Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Meister Keith A.<br><sub>(Last) (First) (Middle)</sub><br>C/O CORVEX MANAGEMENT LP<br>667 MADISON AVENUE<br><sub>(Street)</sub><br>NEW YORK, NY 10065<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2026-05-07 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[X] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>GeneDx Holdings Corp. [ WGS ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Corvex Management LP<br><sub>(Last) (First) (Middle)</sub><br>667 MADISON AVENUE<br><sub>(Street)</sub><br>NEW YORK, NY 10065<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2026-05-07 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[X] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>GeneDx Holdings Corp. [ WGS ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

## Table I - Non-Derivative Securities

---

|  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1. Title of Security | 2. Transaction Date | 2A. Deemed Execution Date | 3. Transaction Code (V) | 3. Transaction Code (V) | 4. Securities Acquired (A) or Disposed of (D) | 4. Securities Acquired (A) or Disposed of (D) | 4. Securities Acquired (A) or Disposed of (D) | 5. Amount of Securities Beneficially Owned | 6. Ownership Form | 7. Nature of Indirect Beneficial Ownership |
| 1. Title of Security | 2. Transaction Date | 2A. Deemed Execution Date | Code | V | Amount | (A) or (D) | Price | 5. Amount of Securities Beneficially Owned | 6. Ownership Form | 7. Nature of Indirect Beneficial Ownership |
| Class A Common Stock | 2026-05-07 |  | P |  | 128181 | A | 35.46<sup>(1)</sup> | 3356331 | I | See footnotes<sup>(2)(3)</sup> |
| Class A Common Stock | 2026-05-07 |  | P |  | 14786 | A | 36.33<sup>(4)</sup> | 3371117 | I | See footnotes<sup>(2)(3)</sup> |
| Class A Common Stock | 2026-05-07 |  | P |  | 123393 | A | 37.6<sup>(5)</sup> | 3494510 | I | See footnotes<sup>(2)(3)</sup> |
| Class A Common Stock | 2026-05-07 |  | P |  | 116412 | A | 38.46<sup>(6)</sup> | 3610922 | I | See footnotes<sup>(2)(3)</sup> |
| Class A Common Stock | 2026-05-07 |  | P |  | 94356 | A | 39.39<sup>(7)</sup> | 3705278 | I | See footnotes<sup>(2)(3)</sup> |
| Class A Common Stock | 2026-05-07 |  | P |  | 56630 | A | 40.46<sup>(8)</sup> | 3761908 | I | See footnotes<sup>(2)(3)</sup> |
| Class A Common Stock | 2026-05-08 |  | P |  | 15745 | A | 38<sup>(9)</sup> | 3777653 | I | See footnotes<sup>(2)(3)</sup> |
| Class A Common Stock | 2026-05-08 |  | P |  | 3396 | A | 38.7<sup>(10)</sup> | 3781049 | I | See footnotes<sup>(2)(3)</sup> |
| Class A Common Stock | 2026-05-08 |  | P |  | 79144 | A | 40.67<sup>(11)</sup> | 3860193 | I | See footnotes<sup>(2)(3)</sup> |
| Class A Common Stock | 2026-05-08 |  | P |  | 73104 | A | 41.15<sup>(12)</sup> | 3933297 | I | See footnotes<sup>(2)(3)</sup> |
| Class A Common Stock | 2026-05-11 |  | P |  | 246734 | A | 38.91<sup>(13)</sup> | 4180031 | I | See footnotes<sup>(2)(3)</sup> |
| Class A Common Stock | 2026-05-11 |  | P |  | 252734 | A | 39.65<sup>(14)</sup> | 4432765 | I | See footnotes<sup>(2)(3)</sup> |
| Class A Common Stock | 2026-05-11 |  | P |  | 532 | A | 40.35<sup>(15)</sup> | 4433297 | I | See footnotes<sup>(2)(3)</sup> |
| Class A Common Stock |  |  |  |  |  |  |  | 333144 | I | See footnote<sup>(16)</sup> |
| Class A Common Stock |  |  |  |  |  |  |  | 20129<sup>(17)</sup> | D |  |

---

## Table II - Derivative Securities

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1. Title of Derivative Security | 2. Conversion or Exercise Price | 3. Transaction Date | 3A. Deemed Execution Date | 4. Transaction Code (V) | 4. Transaction Code (V) | 5. Number of Derivative Securities Acquired (A) or Disposed of (D) | 5. Number of Derivative Securities Acquired (A) or Disposed of (D) | 6. Date Exercisable and Expiration Date | 6. Date Exercisable and Expiration Date | 7. Title and Amount of Underlying Securities | 7. Title and Amount of Underlying Securities | 8. Price of Derivative Security | 9. Number of Derivative Securities Beneficially Owned | 10. Ownership Form | 11. Nature of Indirect Beneficial Ownership |
| 1. Title of Derivative Security | 2. Conversion or Exercise Price | 3. Transaction Date | 3A. Deemed Execution Date | Code | V | (A) | (D) | Date Exercisable | Expiration Date | Title | Amount or Number of Shares | 8. Price of Derivative Security | 9. Number of Derivative Securities Beneficially Owned | 10. Ownership Form | 11. Nature of Indirect Beneficial Ownership |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

---

### Footnotes:

(1) The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $34.97 to $35.94. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares bought at each separate price within the ranges set forth in footnotes (1), (4), (5), (6), (7), (8), (9), (10), (11), (12), (13), (14) and (15) to this Form 4.

(2) Investment funds advised by Corvex Management LP ("Corvex") are the direct holders of 4,433,297 shares of the Class A Common Stock, par value $0.0001 per share ("Class A Common Stock") of GeneDX Holdings Corp. (the "Issuer") reported herein. Mr. Meister may be deemed to indirectly beneficially own these shares by virtue of Mr. Meister's control of the general partner of Corvex.

(3) For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise.

(4) The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $35.97 to $36.84.

(5) The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $37.05 to $38.04.

(6) The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $38.05 to $39.04.

(7) The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $39.05 to $40.04.

(8) The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $40.05 to $40.66.

(9) The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $37.59 to $38.58.

(10) The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $38.59 to $38.94.

(11) The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $39.95 to $40.94.

(12) The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $40.95 to $41.50.

(13) The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $38.22 to $39.21.

(14) The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $39.22 to $40.21.

(15) The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $40.22 to $40.41.

(16) CMLS Holdings LLC ("CMLS Holdings") is the record holder of 333,144 shares of the Class A Common Stock reported herein. Mr. Meister is one of two members of the Board of Managers of CMLS Holdings, and Mr. Meister shares voting and investment discretion with respect to the securities held of record by CMLS Holdings reported herein.

(17) The shares of Class A Common Stock reflected as beneficially owned by Mr. Meister include 20,129 shares of Class A Common Stock that were issued upon the vesting of restricted stock units, that were granted to Mr. Meister in connection with his service on the board of directors of the Issuer.

**Signature:** /s/ Keith A. Meister  
**Date:** 2026-05-11

**Signature:** CORVEX MANAGEMENT LP Name: /s/ Keith Meister Title: Managing Partner  
**Date:** 2026-05-11

### Remarks:

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

**Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.**