# EDGAR Filing Document

**Accession Number:** 0000872625
**File Stem:** 0002071691-26-014422
**Filing Date:** 2026-6
**Character Count:** 45160
**Document Hash:** 221557f96c282bc7f74d6d92c49de9e1
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0002071691-26-014422.hdr.sgml**: 20260624

**ACCESSION NUMBER**: 0002071691-26-014422

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20260430

**FILED AS OF DATE**: 20260624

**DATE AS OF CHANGE**: 20260624

**PERIOD START**: 20260430

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** FRANKLIN STRATEGIC SERIES
- **CENTRAL INDEX KEY:** 0000872625

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** FL
- **FISCAL YEAR END:** 0430

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-06243
- **FILM NUMBER:** 261113769

**BUSINESS ADDRESS:**
- **STREET 1:** ONE FRANKLIN PARKWAY
- **CITY:** SAN MATEO
- **STATE:** CA
- **ZIP:** 94403-1906
- **BUSINESS PHONE:** 650-570-3000

**MAIL ADDRESS:**
- **STREET 1:** ONE FRANKLIN PARKWAY
- **CITY:** SAN MATEO
- **STATE:** CA
- **ZIP:** 94403-1906

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** FRANKLIN CALIFORNIA 250 GROWTH FUND
- **DATE OF NAME CHANGE:** 19911216

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** FRANKLIN CALIFORNIA 250 GROWTH INDEX FUND
- **DATE OF NAME CHANGE:** 19910917

## Series and Classes Contracts Data

### FRANKLIN BIOTECHNOLOGY DISCOVERY FUND (Series ID: S000006882)

| Class ID   | Class Name    | Ticker Symbol   |
|:---|:---|:---|
| C000018631 | CLASS A       | FBDIX           |
| C000081539 | ADVISOR CLASS | FTDZX           |
| C000128862 | Class R6      | FRBRX           |
| C000141458 | Class C       | FBTDX           |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** Franklin Strategic Series

- **b. Investment Company Act file number:** 811-06243

- **c. CIK number of Registrant:** 0000872625

- **d. LEI of Registrant:** 549300NDWC0J6DXVSX36

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** One Franklin Parkway

  - **City:** San Mateo

  - **State:** CA

  - **Foreign country:** US

  - **Zip / Postal Code:** 94403-1906

  - **Telephone number:** 650-312-2000

**Item A.2. Information about the Series.**

- **a. Name of Series:** Franklin Biotechnology Discovery Fund

- **b. EDGAR series identifier (if any):** S000006882

- **c. LEI of Series:** 6N5133EDK315FXQQM036

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2026-04-30

- **b. Date as of which information is reported:** 2026-04-30

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $1075007472.27

**Total Liabilities:** $39017666.46

**Net Assets:** $1035989805.81

**Delayed Delivery Securities:** $6402704.00

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000018631 | 3.23%                | -1.04%               | 2.21%                |
| Class ID C000081539 | 3.25%                | -1.02%               | 2.23%                |
| Class ID C000128862 | 3.25%                | -1.01%               | 2.24%                |
| Class ID C000141458 | 3.17%                | -1.10%               | 2.15%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $11920747.30             | $20722780.39                               |
| Month 2  | $15914478.36             | $-26613103.80                              |
| Month 3  | $43613732.79             | $-20483564.04                              |

### Schedule of Portfolio Investments

| Name                                                     | Title                                                    | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Abivax SA                                                | Abivax SA                                                | CUSIP: 00370M103<br>LEI: 969500D8TMNB184OJU95 | Long             | EC               | CORP              | FR        |    141080 | NS      | $16559970.40  | 1.60%             |  |  |  | No            |                  1 | On Loan: No      |
| Achieve Life Sciences, Inc.                              | Achieve Life Sciences, Inc.                              | CUSIP: 004468500<br>LEI: 549300V82ZKZDTAU0A46 | Long             | EC               | CORP              | US        |   1575682 | NS      | $6917243.98   | 0.67%             |  |  |  | No            |                  1 | On Loan: —       |
| Acumen Pharmaceuticals, Inc.                             | Acumen Pharmaceuticals, Inc.                             | CUSIP: 00509G209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    826400 | NS      | $1975096.00   | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Adicet Bio, Inc.                                         | Adicet Bio, Inc.                                         | CUSIP: 007002207<br>LEI: 549300VRD2QO80WBOP18 | Long             | EC               | CORP              | US        |    225186 | NS      | $1700154.30   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Spyre Therapeutics, Inc.                                 | Spyre Therapeutics, Inc.                                 | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |    103584 | NS      | $7711828.80   | 0.74%             |  |  |  | No            |                  1 | On Loan: No      |
| Jade Biosciences, Inc.                                   | Jade Biosciences, Inc.                                   | CUSIP: 008064206<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    137729 | NS      | $3360587.60   | 0.32%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals, Inc.                            | Alnylam Pharmaceuticals, Inc.                            | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |     54138 | NS      | $16755169.62  | 1.62%             |  |  |  | No            |                  1 | On Loan: No      |
| Alto Neuroscience, Inc.                                  | Alto Neuroscience, Inc.                                  | CUSIP: 02157Q109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    240205 | NS      | $6163660.30   | 0.59%             |  |  |  | No            |                  1 | On Loan: —       |
| Amgen, Inc.                                              | Amgen, Inc.                                              | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |    141974 | NS      | $49158497.50  | 4.75%             |  |  |  | No            |                  1 | On Loan: No      |
| Amylyx Pharmaceuticals, Inc.                             | Amylyx Pharmaceuticals, Inc.                             | CUSIP: 03237H101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    649259 | NS      | $10388144.00  | 1.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Apogee Therapeutics, Inc.                                | Apogee Therapeutics, Inc.                                | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     82737 | NS      | $6858069.93   | 0.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcutis Biotherapeutics, Inc.                            | Arcutis Biotherapeutics, Inc.                            | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    505651 | NS      | $11741216.22  | 1.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Argenx SE                                                | Argenx SE                                                | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |     48962 | NS      | $38274574.64  | 3.69%             |  |  |  | No            |                  1 | On Loan: No      |
| Artiva Biotherapeutics, Inc.                             | Artiva Biotherapeutics, Inc.                             | CUSIP: 04317A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    192871 | NS      | $1974999.04   | 0.19%             |  |  |  | No            |                  1 | On Loan: —       |
| Aura Biosciences, Inc.                                   | Aura Biosciences, Inc.                                   | CUSIP: 05153U107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    765617 | NS      | $5397599.85   | 0.52%             |  |  |  | No            |                  1 | On Loan: —       |
| Avalo Therapeutics, Inc.                                 | Avalo Therapeutics, Inc.                                 | CUSIP: 05338F306<br>LEI: 549300GPK6FPJ3X8SZ39 | Long             | EC               | CORP              | US        |    111577 | NS      | $1495131.80   | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| Bicara Therapeutics, Inc.                                | Bicara Therapeutics, Inc.                                | CUSIP: 055477103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    387402 | NS      | $8360135.16   | 0.81%             |  |  |  | No            |                  1 | On Loan: No      |
| BeOne Medicines Ltd.                                     | BeOne Medicines Ltd.                                     | CUSIP: 07725L102<br>LEI: 549300JFUK6FRD5MH739 | Long             | EC               | CORP              | CH        |     33421 | NS      | $9868218.67   | 0.95%             |  |  |  | No            |                  1 | On Loan: No      |
| Benitec Biopharma, Inc.                                  | Benitec Biopharma, Inc.                                  | CUSIP: 08205P209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    995152 | NS      | $11991581.60  | 1.16%             |  |  |  | No            |                  1 | On Loan: No      |
| BioNTech SE                                              | BioNTech SE                                              | CUSIP: 09075V102<br>LEI: 894500UZJ5LG1F8J1U58 | Long             | EC               | CORP              | DE        |     73400 | NS      | $7593230.00   | 0.73%             |  |  |  | No            |                  1 | On Loan: No      |
| BioAge Labs, Inc.                                        | BioAge Labs, Inc.                                        | CUSIP: 09077V100<br>LEI: 529900NG0C40250Z7875 | Long             | EC               | CORP              | US        |     90709 | NS      | $1528446.65   | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Sanofi SA                                                | Sanofi SA, Escrow Account                                | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | CO        |   2333755 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Bridgebio Pharma, Inc.                                   | Bridgebio Pharma, Inc.                                   | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |    241119 | NS      | $17145972.09  | 1.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Cardiff Oncology, Inc.                                   | Cardiff Oncology, Inc.                                   | CUSIP: 14147L108<br>LEI: 549300AHOLZBHHYFWP04 | Long             | EC               | CORP              | US        |    438961 | NS      | $759402.53    | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| CG oncology, Inc.                                        | CG oncology, Inc.                                        | CUSIP: 156944100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    188240 | NS      | $12563137.60  | 1.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Context Therapeutics, Inc.                               | Context Therapeutics, Inc.                               | CUSIP: 21077P108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1398833 | NS      | $3301245.88   | 0.32%             |  |  |  | No            |                  1 | On Loan: No      |
| Contineum Therapeutics, Inc.                             | Contineum Therapeutics, Inc., Class A                    | CUSIP: 21217B100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    381063 | NS      | $4885227.66   | 0.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytokinetics, Inc.                                       | Cytokinetics, Inc.                                       | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |    161063 | NS      | $10303200.11  | 0.99%             |  |  |  | No            |                  1 | On Loan: No      |
| Dianthus Therapeutics, Inc.                              | Dianthus Therapeutics, Inc.                              | CUSIP: 252828108<br>LEI: 549300Z3N6ODPCOFC890 | Long             | EC               | CORP              | US        |    270799 | NS      | $23776152.20  | 2.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Dyne Therapeutics, Inc.                                  | Dyne Therapeutics, Inc.                                  | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    519232 | NS      | $9112521.60   | 0.88%             |  |  |  | No            |                  1 | On Loan: No      |
| Eikon Therapeutics, Inc.                                 | Eikon Therapeutics, Inc.                                 | CUSIP: 282564103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    127376 | NS      | $1224720.24   | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| enGene Therapeutics, Inc.                                | enGene Therapeutics, Inc.                                | CUSIP: 29286X101<br>LEI: N/A                  | Long             | EC               | CORP              | CA        |    486579 | NS      | $3537429.33   | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| EyePoint, Inc.                                           | EyePoint, Inc.                                           | CUSIP: 30233G209<br>LEI: 549300QE1RU34T50MR69 | Long             | EC               | CORP              | US        |   1123495 | NS      | $14830134.00  | 1.43%             |  |  |  | No            |                  1 | On Loan: No      |
| Gilead Sciences, Inc.                                    | Gilead Sciences, Inc.                                    | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |    368999 | NS      | $48279829.16  | 4.66%             |  |  |  | No            |                  1 | On Loan: No      |
| GRAIL, Inc.                                              | GRAIL, Inc.                                              | CUSIP: 384747101<br>LEI: 2549009XSNESW3VE8024 | Long             | EC               | CORP              | US        |     46433 | NS      | $2529669.84   | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Guardant Health, Inc.                                    | Guardant Health, Inc.                                    | CUSIP: 40131M109<br>LEI: 254900M8C3E5VC8BR186 | Long             | EC               | CORP              | US        |    248985 | NS      | $21681613.80  | 2.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Ideaya Biosciences, Inc.                                 | Ideaya Biosciences, Inc.                                 | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |     81852 | NS      | $2381893.20   | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Immix Biopharma, Inc.                                    | Immix Biopharma, Inc.                                    | CUSIP: 45258H106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    357034 | NS      | $3188313.62   | 0.31%             |  |  |  | No            |                  1 | On Loan: —       |
| Indivior Pharmaceuticals, Inc.                           | Indivior Pharmaceuticals, Inc.                           | CUSIP: 45579U109<br>LEI: 254900MKFFZZSS7N1I14 | Long             | EC               | CORP              | US        |    332496 | NS      | $12229202.88  | 1.18%             |  |  |  | No            |                  1 | On Loan: No      |
| IN8bio, Inc.                                             | IN8bio, Inc.                                             | CUSIP: 45674E208<br>LEI: 549300H68IVCRKSGSL94 | Long             | EC               | CORP              | US        |    332083 | NS      | $488162.01    | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Insmed, Inc.                                             | Insmed, Inc.                                             | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |    214314 | NS      | $29217427.62  | 2.82%             |  |  |  | No            |                  1 | On Loan: No      |
| Franklin Institutional U.S. Government Money Market Fund | Franklin Institutional U.S. Government Money Market Fund | CUSIP: 457756500<br>LEI: 549300M4TP89K77LG374 | Long             | STIV             | RF                | US        |  30710465 | NS      | $30710464.71  | 2.96%             |  |  |  | No            |                  1 | On Loan: No      |
| Inventiva SACA                                           | Inventiva SACA                                           | CUSIP: 46124U107<br>LEI: 969500I9Y690B3FZW590 | Long             | EC               | CORP              | FR        |    969588 | NS      | $4973986.44   | 0.48%             |  |  |  | No            |                  1 | On Loan: —       |
| Ionis Pharmaceuticals, Inc.                              | Ionis Pharmaceuticals, Inc.                              | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |    205400 | NS      | $15355704.00  | 1.48%             |  |  |  | No            |                  1 | On Loan: No      |
| Kailera Therapeutics, Inc.                               | Kailera Therapeutics, Inc.                               | CUSIP: 482931102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    146385 | NS      | $3659625.00   | 0.35%             |  |  |  | No            |                  1 | On Loan: —       |
| LENZ Therapeutics, Inc.                                  | LENZ Therapeutics, Inc.                                  | CUSIP: 52635N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    186907 | NS      | $1678424.86   | 0.16%             |  |  |  | No            |                  1 | On Loan: —       |
| Eli Lilly & Co.                                          | Eli Lilly & Co.                                          | CUSIP: 532457108<br>LEI: FRDRIPF3EKNDJ2CQJL29 | Long             | EC               | CORP              | US        |     14071 | NS      | $13150756.60  | 1.27%             |  |  |  | No            |                  1 | On Loan: No      |
| Sartorius AG                                             | Sartorius AG                                             | CUSIP: N/A<br>LEI: 529900EQV2DY4FOAMU38       | Long             | EP               | CORP              | DE        |      9200 | NS      | $2350384.28   | 0.23%             |  |  |  | No            |                  2 | On Loan: No      |
| Mineralys Therapeutics, Inc.                             | Mineralys Therapeutics, Inc.                             | CUSIP: 603170101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    567545 | NS      | $15125074.25  | 1.46%             |  |  |  | No            |                  1 | On Loan: No      |
| Mirum Pharmaceuticals, Inc.                              | Mirum Pharmaceuticals, Inc.                              | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |    215190 | NS      | $20940138.90  | 2.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Neumora Therapeutics, Inc.                               | Neumora Therapeutics, Inc.                               | CUSIP: 640979100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    186984 | NS      | $461850.48    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences, Inc.                             | Neurocrine Biosciences, Inc.                             | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |    135273 | NS      | $17811395.91  | 1.72%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvalent, Inc.                                           | Nuvalent, Inc., Class A                                  | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     75535 | NS      | $7574649.80   | 0.73%             |  |  |  | No            |                  1 | On Loan: No      |
| Olema Pharmaceuticals, Inc.                              | Olema Pharmaceuticals, Inc.                              | CUSIP: 68062P106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    379464 | NS      | $5468076.24   | 0.53%             |  |  |  | No            |                  1 | On Loan: No      |
| ORIC Pharmaceuticals, Inc.                               | ORIC Pharmaceuticals, Inc.                               | CUSIP: 68622P109<br>LEI: 54930033FJRNEYBW0L25 | Long             | EC               | CORP              | US        |    659005 | NS      | $6510969.40   | 0.63%             |  |  |  | No            |                  1 | On Loan: No      |
| Oruka Therapeutics, Inc.                                 | Oruka Therapeutics, Inc.                                 | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |     94033 | NS      | $6432797.53   | 0.62%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC Therapeutics, Inc.                                   | PTC Therapeutics, Inc.                                   | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |    319652 | NS      | $20796559.12  | 2.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Palisade Bio, Inc.                                       | Palisade Bio, Inc.                                       | CUSIP: 696389154<br>LEI: 549300W6LIDX3I5XXT34 | Long             |  | CORP              | US        |   1447549 | NS      | $2894953.25   | 0.28%             |  |  |  | No            |                  3 | On Loan: No      |
| Palisade Bio, Inc.                                       | Palisade Bio, Inc.                                       | CUSIP: 696389402<br>LEI: 549300W6LIDX3I5XXT34 | Long             | EC               | CORP              | US        |   2119910 | NS      | $4239820.00   | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Phathom Pharmaceuticals, Inc.                            | Phathom Pharmaceuticals, Inc.                            | CUSIP: 71722W107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    487012 | NS      | $5454534.40   | 0.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Praxis Precision Medicines, Inc.                         | Praxis Precision Medicines, Inc.                         | CUSIP: 74006W207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     81426 | NS      | $25961051.58  | 2.51%             |  |  |  | No            |                  1 | On Loan: No      |
| Regeneron Pharmaceuticals, Inc.                          | Regeneron Pharmaceuticals, Inc.                          | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |     61019 | NS      | $43144094.14  | 4.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Relay Therapeutics, Inc.                                 | Relay Therapeutics, Inc.                                 | CUSIP: 75943R102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    232783 | NS      | $3016867.68   | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Revolution Medicines, Inc.                               | Revolution Medicines, Inc.                               | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |    202430 | NS      | $29174211.60  | 2.82%             |  |  |  | No            |                  1 | On Loan: No      |
| Benitec Biopharma, Inc.                                  | Benitec Biopharma, Inc.                                  | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |    310881 | NS      | $3746084.96   | 0.36%             |  |  |  | No            |                  3 | On Loan: No      |
| Satellos Bioscience, Inc.                                | Satellos Bioscience, Inc.                                | CUSIP: 80401L803<br>LEI: 529900EN243BZ5QC9N39 | Long             | EC               | CORP              | CA        |    246407 | NS      | $1958935.65   | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Sensei Biotherapeutics, Inc.                             | Sensei Biotherapeutics, Inc.                             | CUSIP: 81728A207<br>LEI: 8945002MP2CXKAENWU30 | Long             | EC               | CORP              | US        |     48771 | NS      | $1298284.02   | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| ARS Pharmaceuticals, Inc.                                | ARS Pharmaceuticals, Inc.                                | CUSIP: 82835W108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     27681 | NS      | $228645.06    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Sionna Therapeutics, Inc.                                | Sionna Therapeutics, Inc.                                | CUSIP: 829401108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     60891 | NS      | $2356481.70   | 0.23%             |  |  |  | No            |                  1 | On Loan: —       |
| Solid Biosciences, Inc.                                  | Solid Biosciences, Inc.                                  | CUSIP: 83422E204<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1253978 | NS      | $9103880.28   | 0.88%             |  |  |  | No            |                  1 | On Loan: No      |
| SpyGlass Pharma, Inc.                                    | SpyGlass Pharma, Inc.                                    | CUSIP: 85220G109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    109328 | NS      | $2507984.32   | 0.24%             |  |  |  | No            |                  1 | On Loan: —       |
| Structure Therapeutics, Inc.                             | Structure Therapeutics, Inc.                             | CUSIP: 86366E106<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |    101791 | NS      | $4219236.95   | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Syndax Pharmaceuticals, Inc.                             | Syndax Pharmaceuticals, Inc.                             | CUSIP: 87164F105<br>LEI: 529900OF94TRHKZVBS87 | Long             | EC               | CORP              | US        |    492743 | NS      | $10559482.49  | 1.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Tango Therapeutics, Inc.                                 | Tango Therapeutics, Inc.                                 | CUSIP: 87583X109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    447635 | NS      | $9677868.70   | 0.93%             |  |  |  | No            |                  1 | On Loan: No      |
| Thermo Fisher Scientific, Inc.                           | Thermo Fisher Scientific, Inc.                           | CUSIP: 883556102<br>LEI: HCHV7422L5HDJZCRFL38 | Long             | EC               | CORP              | US        |      8579 | NS      | $4108997.84   | 0.40%             |  |  |  | No            |                  1 | On Loan: No      |
| Ultragenyx Pharmaceutical, Inc.                          | Ultragenyx Pharmaceutical, Inc.                          | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |    108067 | NS      | $2668174.23   | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Vaxcyte, Inc.                                            | Vaxcyte, Inc.                                            | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |    145674 | NS      | $8338379.76   | 0.80%             |  |  |  | No            |                  1 | On Loan: No      |
| VeraDermics, Inc.                                        | VeraDermics, Inc.                                        | CUSIP: 922967104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     53904 | NS      | $5336496.00   | 0.52%             |  |  |  | No            |                  1 | On Loan: —       |
| Verastem, Inc.                                           | Verastem, Inc.                                           | CUSIP: 92337C203<br>LEI: 549300IY0EFBIU8NQC81 | Long             | EC               | CORP              | US        |    401744 | NS      | $2193522.24   | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals, Inc.                             | Vertex Pharmaceuticals, Inc.                             | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |     97436 | NS      | $41642197.68  | 4.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Xenon Pharmaceuticals, Inc.                              | Xenon Pharmaceuticals, Inc.                              | CUSIP: 98420N105<br>LEI: 549300XV44Q9Z1MIPQ03 | Long             | EC               | CORP              | CA        |    123767 | NS      | $6935902.68   | 0.67%             |  |  |  | No            |                  1 | On Loan: No      |
| Zentalis Pharmaceuticals, Inc.                           | Zentalis Pharmaceuticals, Inc.                           | CUSIP: 98943L107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    440039 | NS      | $1764556.39   | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| IN8bio, Inc.                                             | IN8bio, Inc., Series C                                   | CUSIP: N/A<br>LEI: 549300H68IVCRKSGSL94       | Long             |  | CORP              | US        |     69673 | NS      | $5664.55      | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Achieve Life Sciences, Inc.                              | Achieve Life Sciences, Inc.                              | CUSIP: N/A<br>LEI: 549300V82ZKZDTAU0A46       | Long             |  | CORP              | US        |    698900 | NS      | $1235342.09   | 0.12%             |  |  |  | No            |                  3 | On Loan: No      |
| Assembly Biosciences, Inc.                               | Assembly Biosciences, Inc., Series A                     | CUSIP: N/A<br>LEI: 5299007Y1X8RBDFT8C40       | Long             | EC               | CORP              | US        |     44450 | NS      | $451057.04    | 0.04%             |  |  |  | No            |                  3 | On Loan: No      |
| Assembly Biosciences, Inc.                               | Assembly Biosciences, Inc., Series B                     | CUSIP: N/A<br>LEI: 5299007Y1X8RBDFT8C40       | Long             | EC               | CORP              | US        |     44450 | NS      | $28190.23     | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Sensei Biotherapeutics, Inc.                             | Sensei Biotherapeutics, Inc., Series B                   | CUSIP: N/A<br>LEI: 8945002MP2CXKAENWU30       | Long             | EP               | CORP              | US        |       132 | NS      | $3363563.39   | 0.32%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Candid Therapeutics, Inc.                                | Candid Therapeutics, Inc.                                | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |   2735200 | NS      | $3046668.16   | 0.29%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Acumen Pharmaceuticals, Inc.                             | Acumen Pharmaceuticals, Inc.                             | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |    223305 | NS      | $533698.95    | 0.05%             |  |  |  | Yes           |                  2 | On Loan: No      |
| Obsidian Therapeutics, Inc.                              | Obsidian Therapeutics, Inc., Series C                    | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |   3667504 | NS      | $3667504.00   | 0.35%             |  |  |  | No            |                  2 | On Loan: No      |
| Ray Therapeutics, Inc.                                   | Ray Therapeutics, Inc., Series B                         | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |   1389029 | NS      | $3399269.27   | 0.33%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Achieve Life Sciences, Inc.                              | Achieve Life Sciences, Inc.                              | CUSIP: N/A<br>LEI: 549300V82ZKZDTAU0A46       | Long             | EC               | CORP              | US        |    706649 | NS      | $2976339.16   | 0.29%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Achieve Life Sciences, Inc.                              | Achieve Life Sciences, Inc.                              | CUSIP: N/A<br>LEI: 549300V82ZKZDTAU0A46       | Long             |  | CORP              | US        |    706649 | NS      | $621851.12    | 0.06%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Oruka Therapeutics, Inc.                                 | Oruka Therapeutics, Inc.                                 | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |    222393 | NS      | $15213905.13  | 1.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Contineum Therapeutics, Inc.                             | Contineum Therapeutics, Inc., Class A                    | CUSIP: 21217B100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    295058 | NS      | $3782643.56   | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Spyre Therapeutics, Inc.                                 | Spyre Therapeutics, Inc.                                 | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |    220000 | NS      | $16379000.00  | 1.58%             |  |  |  | No            |                  1 | On Loan: No      |
| Structure Therapeutics, Inc.                             | Structure Therapeutics, Inc.                             | CUSIP: 86366E106<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |     34633 | NS      | $1435537.85   | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Alto Neuroscience, Inc.                                  | Alto Neuroscience, Inc.                                  | CUSIP: 02157Q109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    165070 | NS      | $4235696.20   | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Satellos Bioscience, Inc.                                | Satellos Bioscience, Inc.                                | CUSIP: 80401L803<br>LEI: 529900EN243BZ5QC9N39 | Long             | EC               | CORP              | CA        |     96830 | NS      | $766313.91    | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Vicore Pharma Holding AB                                 | Vicore Pharma Holding AB                                 | CUSIP: N/A<br>LEI: 549300KTNBPTZLF01130       | Long             | EC               | CORP              | SE        |   1307598 | NS      | $1413428.07   | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Sartorius Stedim Biotech                                 | Sartorius Stedim Biotech                                 | CUSIP: N/A<br>LEI: 52990006IVXY7GCSSR39       | Long             | EC               | CORP              | FR        |     10100 | NS      | $1866598.31   | 0.18%             |  |  |  | No            |                  2 | On Loan: No      |
| Danish Krone                                             | Danish Krone                                             | CUSIP: N/A<br>LEI: N/A                        | Long             | STIV             |  | DK        |       740 | OU      | $116.22       | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Franklin Institutional U.S. Government Money Market Fund | Franklin Institutional U.S. Government Money Market Fund | CUSIP: 457756500<br>LEI: N/A                  | Long             | STIV             | RF                | US        |  31626763 | NS      | $31626763.00  | 3.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Alkermes plc                                             | Alkermes plc                                             | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | IE        |    232937 | NS      | $7852306.27   | 0.76%             |  |  |  | No            |                  1 | On Loan: No      |
| AstraZeneca plc                                          | AstraZeneca plc                                          | CUSIP: N/A<br>LEI: PY6ZZQWO2IZFZC3IOL08       | Long             | EC               | CORP              | GB        |    102531 | NS      | $19211233.47  | 1.85%             |  |  |  | No            |                  1 | On Loan: No      |
| JATT II Acquisition Corp.                                | JATT II Acquisition Corp.                                | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | KY        |    146753 | NS      | $1542374.03   | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Jazz Pharmaceuticals plc                                 | Jazz Pharmaceuticals plc                                 | CUSIP: N/A<br>LEI: 635400GAUMJCLEZRRV50       | Long             | EC               | CORP              | IE        |    283073 | NS      | $57469480.46  | 5.55%             |  |  |  | No            |                  1 | On Loan: No      |
| Ascendis Pharma A/S                                      | Ascendis Pharma A/S                                      | CUSIP: N/A<br>LEI: 549300B66JN3W3J8GH73       | Long             | EC               | CORP              | DK        |    129742 | NS      | $29760219.96  | 2.87%             |  |  |  | No            |                  1 | On Loan: No      |
| Newamsterdam Pharma Co. NV                               | Newamsterdam Pharma Co. NV                               | CUSIP: N/A<br>LEI: 984500B6549TF6E14D36       | Long             | EC               | CORP              | NL        |    187726 | NS      | $5361454.56   | 0.52%             |  |  |  | No            |                  1 | On Loan: —       |
| uniQure NV                                               | uniQure NV                                               | CUSIP: N/A<br>LEI: 724500RPCTZLFYJZ3S98       | Long             | EC               | CORP              | NL        |    175121 | NS      | $3493663.95   | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Carmot Therapeutics, Inc.                                | Carmot Therapeutics, Inc.                                | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |     83100 | NS      | $534288.96    | 0.05%             |  |  |  | No            |                  3 | On Loan: No      |
| Lycia LLC                                                | Lycia LLC, Series C                                      | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | JP        |    859370 | NS      | $3017588.38   | 0.29%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Candid, Inc.                                             | Candid, Inc., Series B                                   | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |   1519609 | NS      | $2372462.20   | 0.23%             |  |  |  | Yes           |                  3 | On Loan: No      |

### Signature

**Date Signed:** 2026-06-01

**Name of Applicant:** Franklin Strategic Series

**Signature:** Monica Krogh

**Name of Signer:** Monica Krogh

**Title:** Assistant Treasurer