# EDGAR Filing Document

**Accession Number:** 0001746466
**File Stem:** 0001193125-23-003658
**Filing Date:** 2023-1
**Character Count:** 17929
**Document Hash:** 3ec99e2b7ee79ca8ae69ab773b0ee13e
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-23-003658.hdr.sgml**: 20230106

**ACCESSION NUMBER**: 0001193125-23-003658

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 5

**FILED AS OF DATE**: 20230106

**DATE AS OF CHANGE**: 20230106

**EFFECTIVENESS DATE**: 20230106

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Equillium, Inc.
- **CENTRAL INDEX KEY:** 0001746466
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 821554746
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-269154
- **FILM NUMBER:** 23515908

**BUSINESS ADDRESS:**
- **STREET 1:** 2223 AVENIDA DE LA PLAYA
- **STREET 2:** SUITE 105
- **CITY:** LA JOLLA
- **STATE:** CA
- **ZIP:** 92037
- **BUSINESS PHONE:** (858) 412-5302

**MAIL ADDRESS:**
- **STREET 1:** 2223 AVENIDA DE LA PLAYA
- **STREET 2:** SUITE 105
- **CITY:** LA JOLLA
- **STATE:** CA
- **ZIP:** 92037

**As filed with the Securities and Exchange Commission on January 6, 2023** 

**Registration No. 333-** 

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**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**Washington, D.C. 20549** 

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**FORM S-8** 

**REGISTRATION STATEMENT** 

***UNDER***

***THE SECURITIES ACT OF 1933***

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## Equillium, Inc.
**(Exact name of registrant as specified in its charter)** 

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---

| | |
|:---|:---|
| **Delaware** | **82-1554746** |
| **(State or other jurisdiction of**<br> **incorporation or organization)** | **(I.R.S. Employer**<br> **Identification No.)** |
| **2223 Avenida de la Playa, Suite 105**<br> **La Jolla, California** | **92037** |
| **(Address of Principal Executive Offices)** | **(Zip Code)** |

---

**2018 Equity Incentive Plan** 

**2018 Employee Stock Purchase Plan** 

**(Full titles of the plans)** 

**Bruce D. Steel** 

**President and Chief Executive Officer** 

**Equillium, Inc.** 

**2223 Avenida de la Playa, Suite 105** 

**La Jolla, California 92037** 

**(Name and Address of agent for service)** 

**(858) 412-5302** 

**(Telephone number, including area code, of agent for service)** 

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***With a copy to:***

**Thomas A. Coll** 

**Cooley LLP** 

**4401 Eastgate Mall** 

**San Diego, California 92121** 

**(858) 550-6000** 

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Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act:

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| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☐ | Accelerated filer | ☐ |
| Non-accelerated filer | ☒ | Smaller reporting company | ☒ |
|  |  | Emerging growth company | ☒ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

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**REGISTRATION OF ADDITIONAL SECURITIES** 

**PURSUANT TO GENERAL INSTRUCTION E** 

This Registration Statement is being filed for the purpose of increasing the number of securities of the same class as other securities for which a Registration Statement of the Registrant on Form S-8 relating to the same employee benefit plans is effective.

The Registrant previously registered shares of its Common Stock for issuance under the Equillium, Inc. 2018 Equity Incentive Plan and Equillium, Inc. 2018 Employee Stock Purchase Plan under Registration Statements on Form S-8 filed with the Securities and Exchange Commission on [October 16, 2018](http://www.sec.gov/Archives/edgar/data/0001746466/000119312518300276/d632051ds8.htm) (File No. 333-227859), [March 27, 2019](http://www.sec.gov/Archives/edgar/data/0001746466/000156459019009583/eq-s8.htm) (File No. 333-230536), as amended, [March 26, 2020](http://www.sec.gov/Archives/edgar/data/1746466/000156459020013212/eq-s8.htm) (File No. 333-237407), [March 24, 2021](http://www.sec.gov/Archives/edgar/data/1746466/000156459021015107/eq-s8.htm) (File No. 333-254656) and [March 23, 2022](http://www.sec.gov/Archives/edgar/data/1746466/000119312522082766/d300923ds8.htm) (File No. 333-263790). Pursuant to General Instruction E to Form S-8, this Registration Statement hereby incorporates by reference the contents of the Registration Statements referenced above.

**Item 8. Exhibits.** 

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| | |
|:---|:---|
| **Exhibit**<br> **Number** | **Description** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.1 | [Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 of the Registrant's Current Report on Form 8-K filed on October 16, 2018).](http://www.sec.gov/Archives/edgar/data/1746466/000119312518300246/d634419dex31.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.2 | [Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.2 of the Registrant's Current Report on Form 8-K filed on October 16, 2018).](http://www.sec.gov/Archives/edgar/data/1746466/000119312518300246/d634419dex32.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.3 | [Form of Common Stock Certificate of the Registrant (incorporated by reference to Exhibit 4.1 of the Registrant's Registration Statement on Form S-1 (File No. 333-227387), as amended, originally filed on September 17, 2018).](http://www.sec.gov/Archives/edgar/data/1746466/000119312518290169/d582934dex41.htm) |
|  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.1\* | [Opinion of Cooley LLP.](d448098dex51.htm) |
|  &nbsp;&nbsp;&nbsp;&nbsp;23.1\* | [Consent of Independent Registered Public Accounting Firm.](d448098dex231.htm) |
|  &nbsp;&nbsp;&nbsp;&nbsp;23.2\* | [Consent of Cooley LLP. Reference is made to Exhibit 5.1.](d448098dex51.htm) |
|  &nbsp;&nbsp;&nbsp;&nbsp;24.1\* | [Power of Attorney. Reference is made to the signature page hereto.](#sig) |
| &nbsp;&nbsp;&nbsp;&nbsp;99.1 | [Equillium, Inc. 2018 Equity Incentive Plan and Forms of Stock Option Grant Notice, Option Agreement and Notice of Exercise thereunder (incorporated by reference to Exhibit 99.2 of the Registrant's Registration Statement on Form S-8 (File No. 333-227859) filed on October 16, 2018).](http://www.sec.gov/Archives/edgar/data/1746466/000119312518300276/d632051dex992.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;99.2 | [Equillium, Inc. 2018 Employee Stock Purchase Plan (incorporated by reference to Exhibit 99.3 of the Registrant's Registration Statement on Form S-8 (File No. 333-227859) filed on October 16, 2018).](http://www.sec.gov/Archives/edgar/data/1746466/000119312518300276/d632051dex993.htm) |
|  107\* | [Filing Fee Table.](d448098dexfilingfees.htm) |

---

\* Filed herewith.

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**SIGNATURES** 

Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of La Jolla, State of California, on January 6, 2023.

---

| | |
|:---|:---|
| **EQUILLIUM, INC.** | **EQUILLIUM, INC.** |
| By: | /s/ Bruce D. Steel |
|  | Bruce D. Steel |
|  | President and Chief Executive Officer (Principal Executive Officer) |

---

**POWER OF ATTORNEY** 

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Bruce D. Steel and Jason A. Keyes, and each of them, as his or her true and lawful attorneys-in-fact and agents, with full power of substitution, for him or her in any and all capacities, to sign any and all amendments to this Registration Statement on Form S-8 (including post-effective amendments), and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or his substitute, may lawfully do or cause to be done by virtue hereof

Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the date indicated.

---

| | | |
|:---|:---|:---|
| **SIGNATURE** | **TITLE** | **DATE** |
| /s/ Bruce D. Steel<br> **Bruce D. Steel** | President, Chief Executive Officer and Director<br> *(Principal Executive Officer)* | January 6, 2023 |
| /s/ Jason A. Keyes<br> **Jason A. Keyes** | Chief Financial Officer<br> *(Principal Financial and Accounting Officer)* | January 6, 2023 |
| /s/ Daniel M. Bradbury<br> **Daniel M. Bradbury** | Chairman of the Board of Directors | January 6, 2023 |
| /s/ Stephen Connelly<br> **Stephen Connelly, Ph.D.** | Chief Scientific Officer and Director | January 6, 2023 |
| /s/ Martha J. Demski | Director | January 6, 2023 |
| **Martha J. Demski** |  |  |
| /s/ Bala S. Manian | Director | January 6, 2023 |
| **Bala S. Manian, Ph.D.** |  |  |
| /s/ Charles McDermott | Director | January 6, 2023 |
| **Charles McDermott** |  |  |
| /s/ Mark Pruzanski | Director | January 6, 2023 |
| **Mark Pruzanski, M.D.** |  |  |
| /s/ Barbara Troupin | Director | January 6, 2023 |
| **Barbara Troupin, M.D.** |  |  |
| /s/ Y. Katherine Xu | Director | January 6, 2023 |
| **Y. Katherine Xu, M.D.** |  |  |

---

## Exhibit 5.1

**Exhibit 5.1**![LOGO](g448098g95x37.jpg)

Thomas A. Coll

+1 858 550 6013

collta@cooley.com

January 6, 2023

Equillium, Inc.

2223 Avenida de la Playa, Suite 105

La Jolla, CA 92037

**Re: Registration Statement on Form S-8** 

Ladies and Gentlemen:

We have acted as counsel to Equillium, Inc., a Delaware corporation (the "***Company***"), in connection with the filing by the Company of a Registration Statement on Form S-8 (the "***Registration Statement***") with the Securities and Exchange Commission (the "***Commission***"), covering the offering of up to 2,063,982 shares (the "***Shares***") of the Company's Common Stock, par value $0.0001 per share ("***Common Stock***"), consisting of (a) 1,720,707 shares of Common Stock issuable pursuant to the Company's 2018 Equity Incentive Plan (the "***2018 EIP***"), and (b) 343,275 shares of Common Stock issuable pursuant to the Company's 2018 Employee Stock Purchase Plan (together with the 2018 EIP, the "***Plans***").

In connection with this opinion, we have examined and relied upon the Registration Statement and related prospectuses, the Plans, the certificate of incorporation and bylaws, each as currently in effect, and originals or copies certified to our satisfaction of such other records, documents, certificates, memoranda and other instruments as in our judgment are necessary or appropriate to enable us to render the opinion expressed below. We have assumed the genuineness of all signatures, the authenticity of all documents submitted to us as originals, the conformity to originals of all documents submitted to us as copies, the accuracy, completeness and authenticity of certificates of public officials, and the due authorization, execution and delivery of all documents by all persons other than by the Company where authorization, execution and delivery are prerequisites to the effectiveness thereof. As to certain factual matters, we have relied upon a certificate of an officer of the Company and have not independently verified such matters.

Our opinion is expressed only with respect to the General Corporation Law of the State of Delaware. We express no opinion to the extent that any other laws are applicable to the subject matter hereof and express no opinion and provide no assurance as to compliance with any federal or state securities law, rule or regulation.

On the basis of the foregoing, and in reliance thereon, we are of the opinion that the Shares, when sold and issued in accordance with the Plans, the Registration Statement and related prospectuses, will be validly issued, fully paid, and nonassessable (except as to Shares issued pursuant to certain deferred payment arrangements, which will be fully paid and nonassessable when such deferred payments are made in full).

[REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK]

Cooley LLP 10265 Science Center Drive San Diego, CA 92121-1117

t: (858) 550-6000 f: (858) 550-6420 cooley.com

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![LOGO](g448098g95x37.jpg)

Equillium, Inc.

January 6, 2023

Page Two

We consent to the filing of this opinion as an exhibit to the Registration Statement. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act of 1933, as amended, or the rules and regulations of the Commission thereunder.

Sincerely,

Cooley LLP

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| | |
|:---|:---|
| By: | /s/ Thomas A. Coll |
|  | Thomas A. Coll |

---

Cooley LLP 10265 Science Center Drive San Diego, CA 92121-1117

t: (858) 550-6000 f: (858) 550-6420 cooley.com

## Exhibit 23.1

**Exhibit 23.1** 

**Consent of Independent Registered Public Accounting Firm** 

We consent to the use of our report dated March 23, 2022, with respect to the consolidated financial statements of Equillium, Inc., incorporated herein by reference.

---

| |
|:---|
| /s/ KPMG LLP |
| <br> San Diego California |
| January 6, 2023 |

---

## Ex-Filing

**Exhibit 107** 

**Calculation of Filing Fee Table** 

**Form S-8** 

(Form Type)

**Equillium, Inc.** 

(Exact Name of Registrant as Specified in its Charter)

<u>Table 1: Newly Registered Securities</u> 

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| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;&nbsp;Security Type | Security Class<br>Title | Fee<br>Calculation<br>Rule | Amount<br>Registered(1) | Proposed<br>Maximum<br>Offering<br>Price Per<br>Unit | Maximum Aggregate<br>Offering Price | Fee Rate | Amount of<br>Registration<br>Fee |
| &nbsp;&nbsp;&nbsp;Equity | Common Stock, $0.0001 par value per share, 2018 Equity Incentive Plan | Rule 457(c) and Rule 457(h) | 1720707 (2) | $1.12(4) | $1927191.84 (4) | 0.0001102 | $212.38 |
| &nbsp;&nbsp;&nbsp;Equity | Common Stock, $0.0001 par value per share, 2018 Employee Stock Purchase Plan | Rule 457(c) and Rule 457(h) | 343275 (3) | $0.95(5) | $326111.25 (5) | 0.0001102 | $35.94 |
| &nbsp;&nbsp;&nbsp;Total Offering Amounts | &nbsp;&nbsp;&nbsp;Total Offering Amounts | &nbsp;&nbsp;&nbsp;Total Offering Amounts | &nbsp;&nbsp;&nbsp;Total Offering Amounts |  | $2253303.09 |  | $248.32 |
| &nbsp;&nbsp;&nbsp;Total Fee Offsets | &nbsp;&nbsp;&nbsp;Total Fee Offsets | &nbsp;&nbsp;&nbsp;Total Fee Offsets | &nbsp;&nbsp;&nbsp;Total Fee Offsets |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Net Fee Due | &nbsp;&nbsp;&nbsp;Net Fee Due | &nbsp;&nbsp;&nbsp;Net Fee Due | &nbsp;&nbsp;&nbsp;Net Fee Due |  |  |  | $248.32 |

---

(1) Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "Securities Act"), this
Registration Statement shall also cover any additional shares of the Registrant's Common Stock (the "Common Stock") that become issuable under the Equillium, Inc. 2018 Equity Incentive Plan (the "2018 Plan") and the
Equillium, Inc. 2018 Employee Stock Purchase Plan (the "2018 ESPP") by reason of any stock dividend, stock split, recapitalization or other similar transaction.

(2) Represents shares of Common Stock that were automatically added to the shares authorized for issuance under the
2018 Plan on January 1, 2023 pursuant to an "evergreen" provision contained in the 2018 Plan. Pursuant to such provision, on January 1 of each year through January 1, 2028, the number of shares authorized for issuance under
the 2018 Plan is automatically increased by an amount equal to the lesser of: (a) 5% of the total number of shares of the Registrant's capital stock outstanding on December 31 of the preceding calendar year and (b) a number of shares
of Common Stock that may be determined by the Registrant's Board of Directors that is less than the preceding clause (a).

(3) Represents shares of Common Stock that were automatically added to the shares authorized for issuance under the
2018 ESPP on January 1, 2023 pursuant to an "evergreen" provision contained in the 2018 ESPP. Pursuant to such provision, on January 1 of each year through January 1, 2028, the number of shares authorized for issuance under
the 2018 ESPP is automatically increased by a number equal to the lesser of: (a) 1% of the total number of shares of the Registrant's capital stock outstanding on December 31 of the preceding calendar year; (b) 343,275 shares; or
(c) a number of shares of Common Stock that may be determined by the Registrant's Board of Directors that is less than (a) and (b).

(4) This estimate is made pursuant to Rule 457(h)(1) and Rule 457(c) of the Securities Act solely for purposes of
calculating the registration fee. The proposed maximum offering price per unit and maximum aggregate offering price are based upon the average of the high and low prices of the Common Stock on January 4, 2023, as reported on The Nasdaq Global
Market.

(5) This estimate is made pursuant to Rule 457(h)(1) and Rule 457(c) of the Securities Act solely for purposes of
calculating the registration fee. The proposed maximum offering price per unit and maximum aggregate offering price are based upon the average of the high and low prices of the Common Stock on January 4, 2023, as reported on The Nasdaq Global
Market, multiplied by 85%, which is the percentage of the price per share applicable to purchases under the 2018 ESPP.