# EDGAR Filing Document

**Accession Number:** 0001493215
**File Stem:** 0001493215-25-000007
**Filing Date:** 2025-8
**Character Count:** 11442
**Document Hash:** 52759963b622e4cd0bc535149b102aee
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001493215-25-000007.hdr.sgml**: 20250814

**ACCESSION NUMBER**: 0001493215-25-000007

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20250630

**FILED AS OF DATE**: 20250814

**DATE AS OF CHANGE**: 20250814

**EFFECTIVENESS DATE**: 20250814

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** RTW INVESTMENTS, LP
- **CENTRAL INDEX KEY:** 0001493215

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-16670
- **FILM NUMBER:** 251214499

**BUSINESS ADDRESS:**
- **STREET 1:** 40 10TH AVENUE
- **STREET 2:** 7TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10014
- **BUSINESS PHONE:** 646-597-6980

**MAIL ADDRESS:**
- **STREET 1:** 40 10TH AVENUE
- **STREET 2:** 7TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10014

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** RTW INVESTMENTS, LLC
- **DATE OF NAME CHANGE:** 20100602

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 06-30-2025

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** RTW INVESTMENTS LP<br>**Address:** 40 10TH AVENUE<br>7TH FLOOR<br>NEW YORK, NY 10014

**Form 13F File Number:** 028-16670

**CRD Number (if applicable):** 000153232

**SEC File Number (if applicable):** 801-78183

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Roderick Wong<br>**Title:** Managing Partner<br>**Phone:** 646-597-6980

**Signature, Place, and Date of Signing:**

/s/ Roderick Wong  NEW YORK, NY  08-14-2025<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 73

**Form 13F Information Table Value Total:** $7021315119

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| 89BIO INC | COM | 282559103 |  | 19321115 | 1967527 | SH |  | SOLE |  | 1967527 | 0 | 0 |
| ABBOTT LABS | COM | 002824100 |  | 60388440 | 444000 | SH |  | SOLE |  | 444000 | 0 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 |  | 194033949 | 8995547 | SH |  | SOLE |  | 8995547 | 0 | 0 |
| ADAGIO MED HLDGS INC | COM | 00534B100 |  | 272169 | 209361 | SH |  | SOLE |  | 209361 | 0 | 0 |
| AKERO THERAPEUTICS INC | COM | 00973Y108 |  | 292282655 | 5477561 | SH |  | SOLE |  | 5477561 | 0 | 0 |
| ALKERMES PLC | SHS | G01767105 |  | 133960288 | 4682289 | SH |  | SOLE |  | 4682289 | 0 | 0 |
| ALLURION TECHNOLOGIES INC | COMMON STOCK | 02008G201 |  | 6178525 | 2542603 | SH |  | SOLE |  | 2542603 | 0 | 0 |
| APOGEE THERAPEUTICS INC | COM | 03770N101 |  | 117786373 | 2712097 | SH |  | SOLE |  | 2712097 | 0 | 0 |
| ARGENX SE | SPONSORED ADR | 04016X101 |  | 371245016 | 673497 | SH |  | SOLE |  | 673497 | 0 | 0 |
| AVIDITY BIOSCIENCES INC | COM | 05370A108 |  | 273175198 | 9618845 | SH |  | SOLE |  | 9618845 | 0 | 0 |
| AXSOME THERAPEUTICS INC | COM | 05464T104 |  | 158349504 | 1516903 | SH |  | SOLE |  | 1516903 | 0 | 0 |
| BETA BIONICS INC | COM | 08659B102 |  | 48036221 | 3299191 | SH |  | SOLE |  | 3299191 | 0 | 0 |
| CARGO THERAPEUTICS INC | COM | 14179K101 |  | 4995755 | 1212562 | SH |  | SOLE |  | 1212562 | 0 | 0 |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 |  | 20102045 | 1529836 | SH |  | SOLE |  | 1529836 | 0 | 0 |
| CERIBELL INC | COM | 15678C102 |  | 2809500 | 150000 | SH |  | SOLE |  | 150000 | 0 | 0 |
| CG ONCOLOGY INC | COM | 156944100 |  | 44231616 | 1701216 | SH |  | SOLE |  | 1701216 | 0 | 0 |
| COMPASS PATHWAYS PLC | SPONSORED ADS | 20451W101 |  | 23021401 | 8221929 | SH |  | SOLE |  | 8221929 | 0 | 0 |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 |  | 10717916 | 2679479 | SH |  | SOLE |  | 2679479 | 0 | 0 |
| CRINETICS PHARMACEUTICALS IN | COM | 22663K107 |  | 13430920 | 467000 | SH |  | SOLE |  | 467000 | 0 | 0 |
| CULLINAN THERAPEUTICS INC | COM | 230031106 |  | 12845879 | 1705960 | SH |  | SOLE |  | 1705960 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 89907060 | 2721158 | SH |  | SOLE |  | 2721158 | 0 | 0 |
| CYTOMX THERAPEUTICS INC | COM | 23284F105 |  | 7857605 | 3461500 | SH |  | SOLE |  | 3461500 | 0 | 0 |
| DYNE THERAPEUTICS INC | COM | 26818M108 |  | 16094198 | 1690567 | SH |  | SOLE |  | 1690567 | 0 | 0 |
| ESTABLISHMENT LABS HLDGS INC | COM | G31249108 |  | 110368235 | 2584131 | SH |  | SOLE |  | 2584131 | 0 | 0 |
| EXAGEN INC | COM | 30068X103 |  | 11844125 | 1696866 | SH |  | SOLE |  | 1696866 | 0 | 0 |
| GE HEALTHCARE TECHNOLOGIES I | COMMON STOCK | 36266G107 |  | 46367820 | 626000 | SH |  | SOLE |  | 626000 | 0 | 0 |
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 |  | 67538171 | 5540457 | SH |  | SOLE |  | 5540457 | 0 | 0 |
| GUARDANT HEALTH INC | COM | 40131M109 |  | 44572312 | 856501 | SH |  | SOLE |  | 856501 | 0 | 0 |
| IMMATICS N.V | SHS | N44445109 |  | 37499418 | 6970152 | SH |  | SOLE |  | 6970152 | 0 | 0 |
| IMMUNIC INC | COM | 4525EP101 |  | 280470 | 402107 | SH |  | SOLE |  | 402107 | 0 | 0 |
| IMMUNOCORE HLDGS PLC | ADS | 45258D105 |  | 152814261 | 4869798 | SH |  | SOLE |  | 4869798 | 0 | 0 |
| INSMED INC | COM PAR $.01 | 457669307 |  | 310429917 | 3084558 | SH |  | SOLE |  | 3084558 | 0 | 0 |
| INTUITIVE SURGICAL INC | COM NEW | 46120E602 |  | 110016615 | 202456 | SH |  | SOLE |  | 202456 | 0 | 0 |
| JADE BIOSCIENCES INC | COM NEW | 008064206 |  | 14478237 | 1449273 | SH |  | SOLE |  | 1449273 | 0 | 0 |
| KESTRA MED TECHNOLOGIES LTD | SHS | G52441105 |  | 3316000 | 200000 | SH |  | SOLE |  | 200000 | 0 | 0 |
| LENZ THERAPEUTICS INC | COM | 52635N103 |  | 25305932 | 863389 | SH |  | SOLE |  | 863389 | 0 | 0 |
| MADRIGAL PHARMACEUTICALS INC | COM | 558868105 |  | 603369434 | 1993687 | SH |  | SOLE |  | 1993687 | 0 | 0 |
| MASIMO CORP | COM | 574795100 |  | 114943717 | 683294 | SH |  | SOLE |  | 683294 | 0 | 0 |
| MERUS N V | COM | N5749R100 |  | 210429088 | 4000553 | SH |  | SOLE |  | 4000553 | 0 | 0 |
| MILESTONE PHARMACEUTICALS IN | COM | 59935V107 |  | 4861838 | 2506102 | SH |  | SOLE |  | 2506102 | 0 | 0 |
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 |  | 34979448 | 741090 | SH |  | SOLE |  | 741090 | 0 | 0 |
| NATERA INC | COM | 632307104 |  | 438170386 | 2593645 | SH |  | SOLE |  | 2593645 | 0 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 |  | 133491830 | 1062072 | SH |  | SOLE |  | 1062072 | 0 | 0 |
| NEUROGENE INC | COM | 64135M105 |  | 20368717 | 1362456 | SH |  | SOLE |  | 1362456 | 0 | 0 |
| OMADA HEALTH INC | COM | 68170A108 |  | 3660000 | 200000 | SH |  | SOLE |  | 200000 | 0 | 0 |
| ORCHESTRA BIOMED HLDGS INC | COM | 68572M106 |  | 22260246 | 8306062 | SH |  | SOLE |  | 8306062 | 0 | 0 |
| ORUKA THERAPEUTICS INC | COM | 687604108 |  | 21810725 | 1945649 | SH |  | SOLE |  | 1945649 | 0 | 0 |
| PENUMBRA INC | COM | 70975L107 |  | 221613606 | 863553 | SH |  | SOLE |  | 863553 | 0 | 0 |
| PERCEPTIVE CAP SOLUTIONS COR | CL A ORD SHS | G70077105 |  | 7885350 | 742500 | SH |  | SOLE |  | 742500 | 0 | 0 |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 |  | 318149430 | 5756277 | SH |  | SOLE |  | 5756277 | 0 | 0 |
| PTC THERAPEUTICS INC | COM | 69366J200 |  | 378334909 | 7746415 | SH |  | SOLE |  | 7746415 | 0 | 0 |
| QUEST DIAGNOSTICS INC | COM | 74834L100 |  | 89815000 | 500000 | SH |  | SOLE |  | 500000 | 0 | 0 |
| RADNET INC | COM | 750491102 |  | 153107477 | 2690344 | SH |  | SOLE |  | 2690344 | 0 | 0 |
| RAPT THERAPEUTICS INC | COM NEW | 75382E208 |  | 11763992 | 1470499 | SH |  | SOLE |  | 1470499 | 0 | 0 |
| REPLIMUNE GROUP INC | COM | 76029N106 |  | 19183943 | 2065010 | SH |  | SOLE |  | 2065010 | 0 | 0 |
| ROCKET PHARMACEUTICALS INC | *W EXP 09/02/202 | 77313F114 |  | 10080 | 350000 | SH |  | SOLE |  | 350000 | 0 | 0 |
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 |  | 43335041 | 17687772 | SH |  | SOLE |  | 17687772 | 0 | 0 |
| SOLENO THERAPEUTICS INC | COM | 834203309 |  | 35556902 | 424408 | SH |  | SOLE |  | 424408 | 0 | 0 |
| SPYRE THERAPEUTICS INC | COM NEW | 00773J202 |  | 54221280 | 3621996 | SH |  | SOLE |  | 3621996 | 0 | 0 |
| STOKE THERAPEUTICS INC | COM | 86150R107 |  | 58152009 | 5123525 | SH |  | SOLE |  | 5123525 | 0 | 0 |
| STRYKER CORPORATION | COM | 863667101 |  | 233626241 | 590517 | SH |  | SOLE |  | 590517 | 0 | 0 |
| TARSUS PHARMACEUTICALS INC | COM | 87650L103 |  | 126054157 | 3111680 | SH |  | SOLE |  | 3111680 | 0 | 0 |
| TAYSHA GENE THERAPIES INC | COM SHS | 877619106 |  | 57799859 | 25021584 | SH |  | SOLE |  | 25021584 | 0 | 0 |
| TEMPUS AI INC | CL A | 88023B103 |  | 25416000 | 400000 | SH |  | SOLE |  | 400000 | 0 | 0 |
| TENAX THERAPEUTICS INC | COM NEW | 88032L605 |  | 2179273 | 378346 | SH |  | SOLE |  | 378346 | 0 | 0 |
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 |  | 62081137 | 1707402 | SH |  | SOLE |  | 1707402 | 0 | 0 |
| UNIQURE NV | SHS | N90064101 |  | 71905740 | 5158231 | SH |  | SOLE |  | 5158231 | 0 | 0 |
| UROGEN PHARMA LTD | COM | M96088105 |  | 62251362 | 4543895 | SH |  | SOLE |  | 4543895 | 0 | 0 |
| VERASTEM INC | COM NEW | 92337C203 |  | 17644206 | 4251616 | SH |  | SOLE |  | 4251616 | 0 | 0 |
| VERONA PHARMA PLC | SPONSORED ADS | 925050106 |  | 288646621 | 3051878 | SH |  | SOLE |  | 3051878 | 0 | 0 |
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 |  | 5850000 | 900000 | SH |  | SOLE |  | 900000 | 0 | 0 |
| XENCOR INC | COM | 98401F105 |  | 18886660 | 2402883 | SH |  | SOLE |  | 2402883 | 0 | 0 |
| ZAI LAB LTD | ADR | 98887Q104 |  | 193624554 | 5536876 | SH |  | SOLE |  | 5536876 | 0 | 0 |

---