# EDGAR Filing Document

**Accession Number:** 0001434265
**File Stem:** 0001558370-23-001700
**Filing Date:** 2023-2
**Character Count:** 844318
**Document Hash:** 56537e7b302e04d8136ff7449c03967b
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001558370-23-001700.hdr.sgml**: 20230222

**ACCESSION NUMBER**: 0001558370-23-001700

**CONFORMED SUBMISSION TYPE**: 6-K

**PUBLIC DOCUMENT COUNT**: 249

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230222

**DATE AS OF CHANGE**: 20230222

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** GENMAB A/S
- **CENTRAL INDEX KEY:** 0001434265
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 000000000

**FILING VALUES:**
- **FORM TYPE:** 6-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-38976
- **FILM NUMBER:** 23651221

**BUSINESS ADDRESS:**
- **STREET 1:** TOLDBODGADE 33
- **CITY:** 1253 COPENHAGEN K
- **STATE:** G7
- **ZIP:** 00000

**MAIL ADDRESS:**
- **STREET 1:** TOLDBODGADE 33
- **CITY:** 1253 COPENHAGEN K
- **STATE:** G7
- **ZIP:** 00000

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**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

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**<br>FORM 6-K**

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**REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16**

**OF THE SECURITIES EXCHANGE ACT OF 1934**

**FOR THE MONTH OF FEBRUARY 2023**

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**COMMISSION FILE NUMBER 001-38976** 

**Genmab A/S**<br> (Exact name of Registrant as specified in its charter)

**Kalvebod Brygge 43**

**1560 Copenhagen V**

**Denmark**

**+45 70 20 27 28**<br> (Address of principal executive offices)

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Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.

Form 20-F ⌧ Form 40-F ◻

This report on Form 6-K shall be deemed to be incorporated by reference in Genmab A/S's registration statements on Form S-8 (File No. 333-232693) and to be a part thereof from the date on which this report is filed, to the extent not superseded by documents or reports subsequently filed or furnished.

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SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

---

| | | |
|:---|:---|:---|
| nthony<br>|  |  |
|  | GENMAB A/S | GENMAB A/S |
|  | BY: | /s/ Anthony Pagano |
|  |  | Name: Anthony Pagano |
|  |  | Title: Executive Vice President & Chief Financial Officer |

---

#### DATE: February 22, 2023

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#### EXHIBIT INDEX

---

| | |
|:---|:---|
| &nbsp;&nbsp;O<br>|  |
| &nbsp;&nbsp;<u>Exhibit</u> | &nbsp;&nbsp;<u>Description of Exhibit</u> |
| &nbsp;&nbsp;99.1 | &nbsp;&nbsp;[Company Announcement Dated February 22, 2023](gmab-20221231xex99d1.htm) |
| &nbsp;&nbsp;99.1 (a) | &nbsp;&nbsp;[Appendix – Genmab A/S Annual Report 2022](gmab-20221231xex99d1a.htm) |
| &nbsp;&nbsp;101.INS | &nbsp;&nbsp;Inline XBRL Instance Document |
| &nbsp;&nbsp;101.SCH | &nbsp;&nbsp;Inline XBRL Taxonomy Extension Schema Document |
| &nbsp;&nbsp;101.CAL | &nbsp;&nbsp;Inline XBRL Taxonomy Extension Calculation Linkbase Document |
| &nbsp;&nbsp;101.DEF | &nbsp;&nbsp;Inline XBRL Taxonomy Extension Definition Linkbase Document |
| &nbsp;&nbsp;101.LAB | &nbsp;&nbsp;Inline XBRL Taxonomy Extension Labels Linkbase Document |
| &nbsp;&nbsp;101.PRE | &nbsp;&nbsp;Inline XBRL Taxonomy Extension Presentation Linkbase Document |

---

------

## Exhibit 99.1

?xml version='1.0' encoding='UTF-8'?

**Exhibit 99.1**

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

**Table of Contents** 

---

| | |
|:---|:---|
| **Management's Review** |  |
| [Our Vision](#_Our_2030_Vision) | 2 |
| [Chair's Statement](#ChairStatement) | 2 |
| [Letter from the CEO](#_Letter_from_the) | 3 |
| [2022 at a Glance](#_2022_at_a) | 4 |
| [Consolidated Key Figures](#ConsolidatedKeyFigures_356731) | 6 |
| [2023 Outlook](#a2020Outlook_830770) | 9 |
| [Our Strategy](#_Our_Strategy) | 11 |
| [Who We Are](#WhoWeAre) | 13 |
| [Business Model](#_Business_Model) | 14 |
| [Research and Development Capabilities](#ResearchandDevelopmentCapabilities_39442) | 15 |
| [Enhancing Commercialization Capabilities to Bring Our Innovations to Patients](#_Enhancing_Commercialization_Capabil_1)  | 16 |
| [Antibody Discovery and Development](#_Our_Approach_to) | 17 |
| [Products and Technologies](#_Pipeline) | 17 |
| [Corporate Social Responsibility and Sustainability Commitments](#_Corporate_Social_Responsibility) | 37 |
| [Genmab's Task Force on Climate-related Financial Disclosures](#TCFD) | 40 |
| [Stakeholder Engagement](#StakeholderEngagement) | 44 |
| [Human Capital Management](#_Human_Capital_Management) | 46 |
| [Financial Review](#FinancialReview_50432) | 48 |
| [Risk Management](#RiskManagement_401944) | 58 |
| [Enterprise Risk Management](#ERM) | 63 |
| [Corporate Governance](#CorporateGovernance_583631) | 64 |
| [Board of Directors](#BoardofDirectors_511627) | 66 |
| [Senior Leadership](#SeniorLeadership_939295) | 69 |
| [Shareholders and Share Information](#ShareholdersandShareInformation_633167) | 71 |
| **[**FINANCIAL STATEMENTS FOR THE GENMAB GROUP**](#FinancialStatementsoftheParent_969857)** | 74 |
| **[**FINANCIAL STATEMENTS FOR THE PARENT COMPANY**](#_Table_of_Contents)** | 131 |
| **[**DIRECTORS' AND MANAGEMENT'S STATEMENT ON THE ANNUAL REPORT**](#DirectorsandManagementsStatement)** | 150 |
| **[**INDEPENDENT AUDITOR'S REPORT**](#IndependentAuditorsReports)S** | 151 |
| **[**Other information**](#OtherInformation)** | 155 |
| **[Glossary](#Glossary)** | 155 |
| **[Forward Looking Statement](#ForwardLookingStatement)** | 157 |
| **[Contact Information](#contactinformation)** | 158 |

---

**Our Reporting Suite**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;●2022 Corporate Responsibility Report (https://ir.genmab.com/static-files/72218610-90a6-4fd3-a76a-d4a7c9c6ef01)

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;●2022 Corporate Governance Report

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;●2022 Compensation Report

Our Corporate Responsibility, Corporate Governance and Compensation Reports for 2022 can be found on our website, Genmab.com.

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

### Our 2030 Vision
By 2030, our KYSO (knock-your-socks-off) antibody medicines are fundamentally transforming the lives of people with cancer and other serious diseases.

**Our Core purpose:** Supporting our 2030 Vision is our core purpose – our unstoppable team will improve the lives of patients through innovative and differentiated antibody therapeutics.

### Chair's Statement
**Dear Shareholder,**

At Genmab, we strive to be innovative and forward-thinking in everything we do, not just in our approach to discovering and developing differentiated antibody therapeutics. As a result, in 2022 the unstoppable team at Genmab built on our already solid foundation with progress throughout our business.

**COMMITMENT TO SUSTAINABILITY AND THE ENVIRONMENT**

Over the past year, we continued our business-driven corporate responsibility strategy with an emphasis on measuring our carbon footprint, setting climate ambitions and targets, and improving our climate-related disclosures. We remained committed to our three previously selected United Nations Sustainable Development Goals (UNSDGs), and added an additional UNSDG, Goal 13: Climate Action.

We are also dedicated to transparency and the continued improvement of our climate disclosures. We have included in our Annual Report our disclosures in accordance with the Task Force on Climate-related Financial Disclosures (TCFD) recommendations. In addition, we have an intention to commit to a climate target to reduce our greenhouse gas (GHG) emissions in line with the Paris Agreement. Because of our focus on sustainability, Genmab scores well on external benchmarking for environmental, social and governance (ESG) and we continually seek ways to improve and remain compliant with existing and new requirements. In 2023, we will continue our commitment to environmental responsibility and sustainability and will look for opportunities to further integrate this commitment into our business. I encourage you to read our 2022 Corporate Responsibility Report for more information.

**EXPERIENCED LEADERSHIP**

**In 2022, we further strengthened our Senior Leadership team with the appointments of Birgitte Stephensen to Chief Legal Officer and Chris Cozic to Chief People Officer. Both leaders have experience in their fields, within and outside of Genmab. Birgitte Stephensen joined Genmab in 2002 and previously served as Genmab's Senior Vice President, Intellectual Property Rights and Legal. Chris Cozic joined Genmab in 2017 and most recently served as Senior Vice President, Global Human Resources.**

**We also saw a change to our Board of Directors with the election of Elizabeth O'Farrell at Genmab's 2022 Annual General Meeting. During her 24-year career at Eli Lilly, Ms. O'Farrell served as CFO of some of the company's largest businesses, including as Head of Global Finance Operations. She has solid financial** 

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 2/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### experience including strategic, operational and financial decision-making and reporting across the value chain as well as expertise in driving global change initiatives.
On behalf of the Board of Directors, I would like to thank Genmab's dedicated team members, CEO Jan van de Winkel and the entire global leadership team for their inspiration and extraordinary leadership as well as our shareholders for their continued support.

Sincerely,

Deirdre P. Connelly

Board Chair

### Letter from the CEO
**Dear Shareholder, A SUCCESSFUL STRATEGY**

When I became CEO of Genmab in 2010 there was an imperative to outline a new strategy – one that would reposition the company to become financially sustainable and allow us to invest in our world-class antibody products and technologies. That three-pronged strategy – to turn science into medicine, build a profitable and successful biotech and focus on our core competence – led quickly to success. Just two years after we unveiled this strategy, we entered into two agreements with Janssen Biotech, Inc. (Janssen) that subsequently resulted in multiple approved medicines: DARZALEX<sup>®</sup> (daratumumab) and DARZALEX *FASPRO*<sup>®</sup> (daratumumab and hyaluronidase-fihj) and the first approved DuoBody<sup>®</sup>-based antibody therapies RYBREVANT<sup>®</sup> (amivantamab) and TECVAYLI<sup>®</sup> (teclistamab). There is potential for an additional DuoBody-based medicine from this collaboration, as Janssen submitted a Biologics License Application (BLA) in December to the U.S. Food and Drug Administration (U.S. FDA) for talquetamab.

The approved medicines form part of the recurring revenue streams that we use to invest back into our company's pipeline, technology and people. The results of this investment were on display in 2022. We celebrated the first full year of Genmab's first approved medicine, Tivdak<sup>®</sup> (tisotumab vedotin-tftv), co-developed with Seagen Inc. (Seagen), being available for certain cervical cancer patients in the U.S. We submitted applications for our own DuoBody-based investigational medicine, epcoritamab, for approval in the U.S. and Japan and our partner AbbVie Inc. (AbbVie) followed suit in Europe. We expanded and advanced our clinical and pre-clinical portfolios, including an expansion of our successful collaboration with BioNTech SE (BioNTech), and we further scaled our organization to be aligned with our portfolio growth and potential future product launches.

#### A VISION ROOTED IN SCIENCE, INSPIRED BY PATIENTS
Soon after we launched our successful strategy, we articulated an ambitious vision for the company – that by 2025, our own product has transformed cancer treatment, and we have a pipeline of KYSO antibodies. To support this vision, we outlined how we would build our capabilities and teams, and we aligned on a series of goals and milestones that we committed to reaching by 2025. These ambitious goals were a roadmap to becoming the company that we knew we could be. I am proud that we have met most of those goals and many more are within reach, giving us an extremely solid foundation on which to continue to build Genmab. With these achievements, we felt that it was time to look beyond our 2025 Vision to continue impacting the

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 3/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

lives of patients and the healthcare community into the future. Together with members of Genmab's leadership team and colleagues throughout the organization, we discussed what would make us feel proud in 2030. We have captured our aspirations for the future with a new vision, that by 2030, *our KYSO antibody medicines are fundamentally transforming the lives of people with cancer and other serious diseases*.

Our 2030 Vision is not a reimagining of what Genmab is, but a bold expansion of what Genmab can be and how our unstoppable team aspires to use our innovation in antibody therapeutics to fundamentally transform the lives of patients. We know that our antibody know-how, assets and technologies can be applied to diseases outside cancer – the approvals of Novartis AG (Novartis)'s Kesimpta<sup>®</sup> (ofatumumab) in relapsing multiple sclerosis (RMS) and Horizon Therapeutics, plc (Horizon)'s TEPEZZA<sup>®</sup> (teprotumumab-trbw) in thyroid eye disease (TED) are proof of this. While we will continue to create and develop new treatment concepts in oncology, we will apply a rigorous approach in identifying areas outside of oncology where our science and expertise may potentially make the biggest difference for patients, with the ultimate goal of improving the lives of as many people as possible.

#### an unstoppable team, a kyso future
As a co-founder of Genmab, I am extremely motivated by the progress we have made, both since I became CEO and over the past year. As a scientist and immunologist, I am truly excited by the potential of our antibodies and by the possibilities for Genmab in 2023, 2030 and beyond.

I can say with confidence that this is not my story alone or the story of our global leadership team – it is the story of our talented and unstoppable Genmab team, of our collaboration partners who believe in the power of antibody therapies, of our supportive Board of Directors, the patients who participate in our clinical trials and their families, the investigators who help us trailblaze innovations, and our shareholders who believe in our vision. We are at the beginning of a fantastic KYSO future that we are creating together, and I thank you for your continued support.

Sincerely yours,

Jan van de Winkel, Ph.D.

President & Chief Executive Officer

### 2022 at a Glance
Operational

● U.S. FDA granted orphan-drug designation to epcoritamab for the treatment of follicular lymphoma (FL)

● Publication by Genmab and collaboration partner AbbVie of topline results from the large B-cell lymphoma (LBCL) cohort of the pivotal EPCORE™ NHL-1 epcoritamab study

● New Phase 3 study for epcoritamab initiated

● Regulatory submissions for subcutaneous (SC) epcoritamab in the U.S. and Japan by Genmab and in Europe by AbbVie

● Epcoritamab BLA accepted for Priority Review by the U.S. FDA with a Prescription Drug User Fee Act (PDUFA) target action date of May 21, 2023

● Epcoritamab Marketing Authorization Application (MAA) validated by the European Medicines Agency (EMA)

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 4/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

● First full year of Tivdak, co-development with Seagen, available for certain cervical cancer patients in the U.S.

● Continued development of commercialization capabilities and Genmab's broader organizational infrastructure with the addition of 448 new colleagues

● Expansion of global strategic collaboration with BioNTech, including investigational medicine HexaBody <sup>®</sup> -CD27 (GEN1053/BNT313)

● Second DuoBody-based medicine to receive regulatory approval: Janssen's TECVAYLI

Financial

● DKK 194B

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o 2022 year-end market cap

● DKK 14,595M

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o 2022 revenue

● DKK 8,238M

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o 2022 operating expenses 68% invested in research and development (R&D)

● Liquidity and Capital Resources

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Marketable securities – DKK 12,431M

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Cash and cash equivalents – DKK 9,893M

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Shareholders ' equity – DKK 27,441M

![Graphic](gmab-20221231xex99d1003.jpg)

2020 Operating Profit impacted by one-time AbbVie upfront payment.

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| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 5/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

### Consolidated Key Figures

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| **(DKK million)**<br>**Income Statement** | <br>**2018\*** | **2019** | **2020** | **2021** | **2022** |
| Revenue | 3025 | 5366 | 10111 | 8482 | 14595 |
| Research and development expenses | (1431) | (2386) | (3137) | (4181) | (5562) |
| Selling, general and administrative expenses | (214) | (342) | (661) | (1283) | (2676) |
| Operating expenses | (1645) | (2728) | (3798) | (5464) | (8238) |
| Operating profit | 1380 | 2638 | 6313 | 3018 | 6357 |
| Net financial items | 232 | 221 | (409) | 965 | 678 |
| Net profit  | 1472 | 2166 | 4758 | 3008 | 5522 |
| **Balance Sheet** |  |  |  |  |  |
| Marketable securities | 5573 | 7419 | 8819 | 10381 | 12431 |
| Cash and cash equivalents | 533 | 3552 | 7260 | 8957 | 9893 |
| Total non-current assets | 1028 | 1183 | 2352 | 1891 | 1901 |
| Total assets | 8461 | 15144 | 21143 | 24627 | 30278 |
| Shareholders' equity | 8014 | 14048 | 19121 | 22196 | 27441 |
| Share capital | 61 | 65 | 66 | 66 | 66 |
| **Cash Flow Statement** |  |  |  |  |  |
| Cash flow from operating activities | 1015 | 1326 | 6433 | 2228 | 3912 |
| Cash flow from investing activities | (1778) | (1983) | (2351) | (961) | (2761) |
| Cash flow from financing activities | (71) | 3660 | 71 | (420) | (789) |
| Investments in intangible and tangible assets | (478) | (111) | (307) | (252) | (317) |
| **Financial Ratios and Other Information** |  |  |  |  |  |
| Basic net profit per share | 24.03 | 34.40 | 73.00 | 46.00 | 84.45 |
| Diluted net profit per share | 23.73 | 34.03 | 72.21 | 45.54 | 83.65 |
| Year-end share market price | 1067.50 | 1481.50 | 2463.00 | 2630.00 | 2941.00 |
| Price / book value | 8.19 | 6.85 | 8.50 | 7.82 | 7.07 |
| Shareholders' equity per share | 130.32 | 216.12 | 289.71 | 336.30 | 415.77 |
| Equity ratio | 95% | 93% | 90% | 90% | 91% |
| Shares outstanding | 61497571 | 65074502 | 65545748 | 65718456 | 65961573 |
| Average number of employees (FTE)\*\* | 313 | 471 | 656 | 1022 | 1460 |
| Number of employees (FTE) at year-end | 377 | 548 | 781 | 1212 | 1660 |

---

\* Prior period amounts have not been adjusted under the modified retrospective method to adopt International Financial Reporting Standards (IFRS) 16 as of January 1, 2019

\*\* Full-time equivalent (FTE) or team members

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| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 6/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT**![Graphic](gmab-20221231xex99d1004.jpg)

![Graphic](gmab-20221231xex99d1006.jpg)

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| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 7/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT**![Graphic](gmab-20221231xex99d1005.jpg)

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| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 8/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

### 2023 Outlook

---

| | | |
|:---|:---|:---|
| (DKK million) | 2023 Guidance | 2022 Actual Result |
| Revenue | 14600 - 16100 | 14595 |
| Operating expenses | (9800) - (10600) | (8238) |
| Operating profit | 3,900 - 6,200\* | 6357 |

---

*\*Operating profit does not sum due to rounding*

#### Revenue
Genmab expects its 2023 revenue to be in the range of DKK 14,600 – 16,100 million, compared to DKK 14,595 million in 2022. Our revenue in 2022 was driven primarily by DARZALEX royalties due to the continued strong growth of DARZALEX net sales, favorable exchange rate movements between the USD and DKK and the positive impact of applying the DARZALEX contractual annual Currency Hedge Rate.

Genmab's projected revenue growth for 2023 is driven by recurring revenues related to DARZALEX, TEPEZZA and Kesimpta royalties from net sales growth, partly offset by negative exchange rate movements between the USD and DKK due to a lower assumed USD/DKK exchange rate.

Genmab's projected revenue for 2023 primarily consists of DARZALEX royalties of DKK 10,400 – 11,100 million. Such royalties are based on estimated DARZALEX 2023 net sales of USD 9.4 – 10.0 billion compared to actual net sales in 2022 of approximately USD 8.0 billion. DARZALEX royalties are partly offset by Genmab's share of Janssen's royalty payments to Halozyme Therapeutics, Inc. (Halozyme) in connection with SC net sales. The remainder of Genmab's revenue consists of increasing royalties from TEPEZZA, Kesimpta, RYBREVANT and TECVAYLI, reimbursement revenue, milestones including those for epcoritamab and collaboration revenue with Seagen for Tivdak.

#### Operating Expenses
Genmab anticipates its 2023 operating expenses to be in the range of DKK 9,800 – 10,600 million, compared to DKK 8,238 million in 2022. The growth in operating expenses is to support Genmab's continued portfolio advancement and investing for future product launches, including epcoritamab.

#### Operating Profit
Genmab expects our operating profit to be in the range of DKK 3,900 – 6,200 million in 2023, compared to DKK 6,357 million in 2022.

#### Outlook: Risks and Assumptions
In addition to factors already mentioned, the estimates above are subject to change for numerous reasons including but not limited to: the achievement of certain milestones associated with Genmab's collaboration agreements; the timing and variation of development activities (including activities carried out by Genmab's collaboration partners) and related income and costs; DARZALEX, DARZALEX *FASPRO,* Kesimpta, TEPEZZA, RYBREVANT and TECVAYLI net sales and royalties paid to Genmab; changing rates of inflation; and currency exchange rates (the 2023 guidance assumes a USD/DKK exchange rate of 6.8). The financial

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 9/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

guidance assumes that no significant new agreements are entered into during 2023 that could materially affect the results. Additionally, depending on trends related to the coronavirus and future variants, the COVID-19 pandemic could potentially have a material adverse impact on Genmab's business and financial performance, including clinical trials, projected regulatory approval timelines, supply chain and revenues, and cause Genmab's actual results to differ materially from 2023 Guidance and Key 2023 Priorities in this annual report.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 10/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

---

| | | | |
|:---|:---|:---|:---|
| &nbsp;&nbsp;Tokyo, JapanTokyo, Japanur Strategy<br>|  |  |  |
| **Our Strategy** | **Our Strategy** | **Our Strategy** | **Our Strategy** |
| &nbsp;&nbsp;**Business Strategy** | &nbsp;&nbsp;**Priorities in 2022** | &nbsp;&nbsp;**Priorities for 2023** | &nbsp;&nbsp;**Link to Risk**  |
| &nbsp;&nbsp;Build a profitable and successful biotech<br>● Maintain a flexible and capital-efficient model<br>● Maximize relationships with partners<br>● Retain ownership of select products<br>| &nbsp;&nbsp;Further scale organization aligned with growing product portfolio and brand needs<br>● Further scale organization aligned with differentiated antibody product portfolio growth and future launches<br>● Use solid financial base to grow and broaden antibody product and technology portfolio<br>| &nbsp;&nbsp;Invest in our people and culture<br>● Further scale organization aligned with differentiated antibody product portfolio growth and future launches<br>Become a leading integrated biotech innovation powerhouse<br>● Use solid financial base to grow and broaden antibody product and technology portfolio<br>| &nbsp;&nbsp;Please refer to the risks included in this Annual Report. |
| &nbsp;&nbsp;Focus on core competence<br>● Identify the best disease targets<br>● Develop unique first-in-class or best-in-class antibodies<br>● Develop next-generation technologies<br>| &nbsp;&nbsp;Growth and development of differentiated early-stage product candidates<br>●  DuoBody-PD-L1x4-1BB<sup>1</sup> & DuoBody-CD40x4-1BB<sup>1</sup> <br>o<br>Data from clinical expansion cohorts to progress to next steps<br>● Expand and advance proprietary clinical product portfolio<br>| &nbsp;&nbsp;Build a world-class differentiated pipeline<br>●  DuoBody-PD-L1x4-1BB <br>o<br>Establish proof of concept data in solid tumor indication<br>● DuoBody-CD40x4-1BB<br>o<br>Establish efficacy and safety data in solid tumor indication<br>o<br>Progress towards late-stage clinical development<br>● Expand and advance proprietary clinical product portfolio<br>| &nbsp;&nbsp;Please refer to the risks included in this Annual Report.  |

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| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

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| | | | |
|:---|:---|:---|:---|
| &nbsp;&nbsp;Turn science into medicine<br>● Create differentiated antibody therapeutics with significant commercial potential<br>| &nbsp;&nbsp;Broad and rapid development of late-stage clinical pipeline and further build U.S. country organization<br>● Epcoritamab<sup>2</sup><br>o<br>Expand clinical development program with multiple Phase 3 trials initiated and submission of first BLA (subject to supportive U.S. FDA feedback)<br>● Tivdak<sup>3</sup><br>o<br>Establish Tivdak as a clear choice for second-line (2L) + recurrent or metastatic cervical cancer patients<br>● Broaden clinical development program including Phase 2 evaluation of combination therapy in earlier line treatment for cervical cancer and other solid tumors<br>| &nbsp;&nbsp;Bring our own medicines to patients<br>● Epcoritamab<br>o<br>Launch in relapsed/refractory diffuse large B-cell lymphoma (DLBCL)<sup>4</sup><br>o<br>Submit a supplemental BLA (sBLA)<sup>5</sup><br>o<br>Broaden clinical development program<br>● Tivdak<br>o<br>Progress successful uptake in 2L+ recurrent or metastatic cervical cancer patients<br>o<br>Progress clinical development program<br>| &nbsp;&nbsp;Please refer to the risks included in this Annual Report. |
| &nbsp;&nbsp;**CSR Strategy** | &nbsp;&nbsp;**Priorities in 2022** | &nbsp;&nbsp;**Priorities for 2023** | &nbsp;&nbsp;**Link to Risk** |

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| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

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| | | | |
|:---|:---|:---|:---|
| &nbsp;&nbsp;Commitment to our business-driven Corporate Social Responsibility (CSR) strategy, which focuses on four pillars:<br>◾<br>Science-driven health innovations for patients<br>◾<br>Employee well-being and vitality<br>◾<br>Ethics and transparency<br>◾<br>Environmental and community sustainability<br>| &nbsp;&nbsp;◾<br>Continue strong commitment to being a responsible and sustainable biotech<br>◾<br>Look for opportunities to further integrate ESG into our strategic planning and risk management processes<br>◾<br>Monitor ESG matters of relevance to our business operations<br>◾<br>Establish clear goals to measure our performance<br>● Establish climate ambitions, targets, and emissions reductions and integrate climate-related financial risks into Genmab's Enterprise Risk Management (ERM) program<br>| &nbsp;&nbsp;◾<br>Continue strong commitment to being a sustainable and responsible company<br>◾<br>Further integrate ESG into our strategic planning, operations and risk management processes<br>◾<br>Further formalize total CO<sub>2</sub> emissions mapping<br>◾<br>Further define and communicate Genmab's commitment to successfully attract, motivate, retain and reward top talent<br>◾<br>Enhance Diversity, Equity and Inclusion (DE&I) processes and efforts <br>◾<br>Monitor regulatory landscape and prepare for new ESG-related reporting requirements<br>| &nbsp;&nbsp;Please refer to the risks included in Genmab's 2022 Corporate Responsibility report, https://ir.genmab.com/static-files/72218610-90a6-4fd3-a76a-d4a7c9c6ef01 |

---

1. Co-development with BioNTech; 2. Co-development with AbbVie; 3. Co-development with Seagen; 4. Subject to regulatory approvals; 5. Subject to supportive U.S. FDA feedback

**Who We Are**

**Our Core Values**

In our quest to turn science into medicine, we use these guideposts to transform the future of cancer treatment:

● Passion for innovation

● Determination — being the best at what we do

● Integrity — we do the right thing

● We work as one team and respect each other

**Genmab's Growing Organization and Growing Presence**

● Copenhagen, DK

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Headquarters

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| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Chemistry, Manufacturing and Controls (CMC) Operations

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Clinical Operations

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Corporate Functions

● Utrecht, NL

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Research

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Translational Research

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Antibody Product Creation

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Corporate Functions

● Princeton, USA

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Translational Research

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Development

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o U.S. Market Operations

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Corporate Functions

● Tokyo, JP

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Japan Clinical Operations

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Japan Market Operations

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Corporate Functions

**Our Key Accomplishments**

Each of our achievements stands as evidence of our unyielding determination, including:

● Tivdak, Genmab's first approved medicine, co-developed and co-promoted in the U.S. in partnership with Seagen

● Inventors of four proprietary antibody technologies

● Growing proprietary clinical programs

● Pioneers of a robust pre-clinical pipeline

● Forty investigational new drug applications (INDs) filed by Genmab and/or partners, based on Genmab's innovations and technology, since 1999

● World-class team with deep antibody know-how, and R&D and commercial expertise

● Partnerships with industry leaders and innovators

● Solid financial foundation

● Building and expanding our capabilities with more than 1,600 team members across our international locations

### Business Model

#### At Genmab, we have built a profitable and successful biotech that creates value for our stakeholders.
Our Strengths and Differentiators

● World-class antibody biology knowledge and deep insight into disease targets

● Discovery and development engine with proprietary technologies that allow us to build a world-class pipeline

● In-house expertise with a solid track record of building successful strategic partnerships

● Robust pipeline of potential best-in-class and first-in-class therapies

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| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

● Experienced, diverse leadership team

Building a Fully Integrated Biotech Innovation Powerhouse

● Team: flexible and adaptive infrastructure

● Translational research and data science: key to accelerating development and ensuring the right therapies get to the right patients

● Collaboration: across innovation ecosystem of pharma, biotech and academia, drives our business forward

● Strong financials: growing recurring revenues and focused investments

Research: track record of success and investing for tomorrow

Development: scaling up capabilities to expand from early- to late-stage development

Commercialization: building the next step in our evolution

Enabling functions: supporting growth and managing risk

The value we create for stakeholders

Patients

25 ongoing or announced clinical trials with Genmab owned (≥50%) products

Our People

448 new full-time jobs created in 2022

Investors

12% increase in market capitalization in 2022

Collaborations

Research agreements and collaborations in place across innovation ecosystem of pharma, biotech and academia

### Research and Development Capabilities
**Inspired by Nature**

At Genmab, we are inspired by nature and understand how antibodies work. We are deeply knowledgeable about antibody biology and our scientists harness this expertise to create and develop differentiated investigational antibody medicines. We utilize a sophisticated and highly automated process to efficiently generate, select, produce and evaluate human antibody-based products. Our teams have established a fully integrated R&D enterprise and streamlined process to coordinate the activities of antibody product discovery, pre-clinical testing, manufacturing, clinical trial design and execution, and regulatory submissions across Genmab's international operations. Through our expertise in antibody drug development, we pioneer technologies that allow us to create differentiated and potentially first-in-class or best-in-class investigational medicines with the potential to improve patients' lives. Our antibody expertise has enabled us to create our cutting-edge technology platforms: DuoBody, HexaBody, DuoHexaBody<sup>®</sup> and HexElect<sup>®</sup>.

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| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

To connect patients with the right medicine at the right dose, we are also transforming Genmab; building on our world-class research in antibodies to expand our capabilities beyond the lab. We have expanded our scientific focus to use data science and artificial intelligence to aid in the discovery of new targets and biomarkers and bolster our in-depth translational medicine laboratory capabilities.

**Sustainable and State-of-the-Art Facilities**

The Netherlands

Genmab's discovery and pre-clinical research is conducted at our R&D Center in Utrecht, the Netherlands, one of the first Building Research Establishment Environmental Assessment Method (BREEAM) Excellent laboratory buildings in the Netherlands. The R&D Center is located in close proximity to other life sciences companies and a world-class research university. It houses state-of-the-art laboratories including an advanced robotics lab, a modern auditorium, science café, and innovative brainstorming and meeting rooms. The space provides a bright, open and collaborative atmosphere to enable the Genmab team to continue to innovate and find new ways to help patients.

To accommodate Genmab's growth, we will occupy most of the new "Accelerator" multi-tenant building, connected directly to the Genmab R&D Center. It is designed to achieve the same BREEAM Excellent high sustainability standard. Expansion into this building, which will contain both offices and laboratories, is expected in 2023.

United States

Genmab opened its new U.S. facility in 2020. This space, modeled on the open and collaborative spirit of the R&D Center in Utrecht, includes both offices and laboratories. The U.S. translational research laboratories allow Genmab to expand our translational pre-clinical and clinical drug development research expertise and are part of the strategic growth of the Company. As with the construction and design of our Utrecht facilities, our U.S. office and laboratories were designed and built with sustainability in mind and meet the requirements for Leadership in Energy and Environmental Design (LEED) Gold certification for sustainable design features. Additionally, 75% of the construction waste created when building out the facility was recycled, rather than being sent to a landfill.

As Genmab continues to grow our geographical footprint, we will endeavor to do so with minimal impact to the environment and with sustainability as a key area of focus.

### Enhancing Commercialization Capabilities to Bring Our Innovations to Patients
Our 2030 Vision is for Genmab's KYSO antibody medicines to fundamentally transform the treatment of cancer and other serious diseases. We are becoming an integrated end-to-end biotech innovation powerhouse that discovers, develops, and delivers next-generation antibody-based medicines to patients. Through the addition of key talent and the purposeful and strategic growth of our capabilities, we have never been in a better position to achieve our Vision.

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| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

Key to our ability to bring our medicines to patients is commercialization. Over the past few years, we have made tremendous progress in building and establishing this important capability, first in the U.S. and Japan, through a disciplined and integrated approach.

● In the third quarter of 2021, together with our partner Seagen, we launched our first marketed medicine, Tivdak, in the U.S. Since its launch, Tivdak is on the way to becoming the clear second-line choice for women with recurrent or metastatic cervical cancer with more than 900 women estimated to have received treatment as of December 2022.

● We continue to expand our capabilities as we prepare for the potential launch of epcoritamab in the U.S. and Japan, pending regulatory approvals, by deepening our talent base, focusing on impactful approaches and optimal access for all appropriate patients.

● Our commercialization team is anchored in highly experienced leaders and teams across functions: medical affairs, marketing, market access, insights and analytics as well as field-based teams in the U.S. to ensure the best possible experience for care teams and their patients treated with our medicines.

● We have built a global commercial team to help shape our development and go-to-market strategy in close partnership with R&D. Building a deep understanding of the potential and evolution of markets/segments will help ensure a thoughtful approach to advancing our pipeline.

**At Genmab, commercialization is an integrated approach guided by our commitment to the patients we serve; everyone doing their part to ensure patients get the most from our next-generation differentiated antibody-based medicines.** 

### Antibody Discovery and Development
**We are experts in antibody discovery and development. Our appreciation for, and understanding of, the power of the human immune system gives us a unique perspective on how to respond to the constant challenges of oncology drug development. We entered a new chapter with the commercialization and launch of our first medicine, co-owned with Seagen, in 2021, and we are preparing for the potential launch of our second medicine in 2023 under our collaboration with AbbVie.** 

#### Products and Technologies
**Pipeline**

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| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

information is available on Genmab's website, www.genmab.com. The information accessible through our website is not part of and is not incorporated by reference herein.

**Genmab's Proprietary Pipeline (≥50% Genmab ownership)\***

*Approved Medicine*

Tivdak (tisotumab vedotin-tftv)

*Clinical Stage Investigational Medicines*

Epcoritamab

DuoBody-PD-L1x4-1BB (GEN1046/BNT311)

DuoBody-CD40x4-1BB (GEN1042/BNT312)

DuoHexaBody-CD37 (GEN3009)

HexaBody-CD38 (GEN3014)

DuoBody-CD3xB7H4 (GEN1047)

HexaBody-CD27 (GEN1053/BNT313)

GEN1056 (BNT322)

\* Tisotumab vedotin co-development with Seagen; epcoritamab co-development with AbbVie; DuoBody-PD-L1x4-1BB, DuoBody-CD40x4-1BB, HexaBody-CD27 and GEN1056 co-development with BioNTech; Genmab is developing HexaBody-CD38 in an exclusive worldwide license and option agreement with Janssen.

**Programs Incorporating Genmab's Innovations and Technology in Phase 2 Development or Later**

*Approved Medicines*

DARZALEX/DARZALEX *FASPRO* (daratumumab/daratumumab and hyaluronidase-fihj, Janssen)

Kesimpta (ofatumumab, Novartis)

TEPEZZA (teprotumumab-trbw, Horizon)

RYBREVANT (amivantamab, Janssen)

TECVAYLI (teclistamab, Janssen)

*≥ Phase 2 Clinical Stage Investigational Medicines*

Talquetamab (Janssen)

Inclacumab (Global Blood Therapeutics, now owned by Pfizer)

Mim8 (Novo Nordisk A/S (Novo Nordisk))

Camidanlumab tesirine (ADC Therapeutics)

PRV-015 (Provention Bio)

Lu AF82422 (Lundbeck)

Additional investigational medicines are in early-stage clinical development.

#### Genmab's Proprietary<sup>1</sup>Products
**Approved Medicine**

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| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

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| | | |
|:---|:---|:---|
| &nbsp;&nbsp;**Approved Product** | &nbsp;&nbsp;**Target** | &nbsp;&nbsp;**Developed By** |
| &nbsp;&nbsp;**Tivdak**<br>(tisotumab vedotin-tftv) | &nbsp;&nbsp;Tissue factor (TF) | &nbsp;&nbsp;Co-development Genmab/Seagen<br> &nbsp;&nbsp;Adult patients with recurrent or metastatic cervical cancer with disease progression on or after chemotherapy<sup>2</sup> |

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<sup>1</sup>Approved and investigational medicines where Genmab has ≥50% ownership, in co-development with partners as indicated.

<sup>2</sup>Refer to local country prescribing information for precise indication and safety information.

**Pipeline, Including Further Development for Approved Medicine**

![Graphic](gmab-20221231xex99d1008.jpg)

<sup>1</sup>In June 2022, AbbVie decided to discontinue co-development of DuoHexaBody-CD37. Upon expiry of the 180-day notice period on December 24, 2022, Genmab became solely responsible for the further development of DuoHexaBody-CD37 against low-single digit royalty payments to AbbVie, up to an agreed maximum total royalty amount, based on future potential sales of the product.

<sup>2</sup>Genmab is developing HexaBody-CD38 in an exclusive worldwide license and option agreement with Janssen.

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| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

#### Programs Incorporating Genmab's Innovation and Technology<sup>1</sup>
**Approved Medicines**

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| | | |
|:---|:---|:---|
| &nbsp;&nbsp;**Approved Product** | &nbsp;&nbsp;**Discovered and/or Developed & Marketed By** | &nbsp;&nbsp;**Disease Indication(s)** |
| &nbsp;&nbsp;**DARZALEX**<br>(daratumumab)/**DARZALEX *FASPRO*** (daratumumab and hyaluronidase-fihj)  | &nbsp;&nbsp;Janssen (Royalties to Genmab on net global sales) | &nbsp;&nbsp;Multiple myeloma<sup>2</sup> |
| &nbsp;&nbsp;**DARZALEX**<br>(daratumumab)/**DARZALEX *FASPRO*** (daratumumab and hyaluronidase-fihj)  | &nbsp;&nbsp;Janssen (Royalties to Genmab on net global sales) | &nbsp;&nbsp;Light-chain (AL) Amyloidosis |
| &nbsp;&nbsp;**Kesimpta**<br>(ofatumumab) | &nbsp;&nbsp;Novartis (Royalties to Genmab on net global sales) | &nbsp;&nbsp;RMS<sup>2</sup><br>|
| &nbsp;&nbsp;**TEPEZZA** <br>(teprotumumab-trbw) | &nbsp;&nbsp;Horizon (under sublicense from Roche, royalties to Genmab on net global sales) | &nbsp;&nbsp;TED<sup>2</sup> |
| &nbsp;&nbsp;**RYBREVANT**<br>(amivantamab/amivantamab-vmjw) | &nbsp;&nbsp;Janssen (Royalties to Genmab on net global sales) | &nbsp;&nbsp;NSCLC<sup>2</sup> |
| &nbsp;&nbsp;T**ECVAYLI** <br>(teclistamab/teclistamab-cqyv) | &nbsp;&nbsp;Janssen (Royalties to Genmab on net global sales) | &nbsp;&nbsp;Relapsed and refractory multiple myeloma<sup>2</sup> |

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<sup>2</sup>See local prescribing information for precise indication and safety information.

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| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

**Pipeline, Including Further Development for Approved Medicines, ≥Phase 2 Development**

![Graphic](gmab-20221231xex99d1009.jpg)

\*UltiMab transgenic mouse technology licensed from Medarex, Inc. (Medarex), a wholly owned subsidiary of Bristol-Myers Squibb

### Genmab's Proprietary Pipeline
**Programs where Genmab has ≥50% ownership.**

#### Tivdak (tisotumab vedotin-tftv)

#### First and Only U.S. FDA Approved Antibody-drug Conjugate (ADC) for Recurrent or Metastatic Cervical Cancer
● **An ADC directed to TF, a protein highly prevalent on solid tumors, including cervical cancer, which is associated with poor prognosis** 

● **Accelerated approval granted by the U.S. FDA for Tivdak, the first and only approved ADC for the treatment of adult patients with recurrent or metastatic cervical cancer with disease progression on or after chemotherapy** 

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| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

● **U.S. FDA approval was based on data from the innovaTV 204 (NCT03438396) Phase 2 single-arm clinical study evaluating tisotumab vedotin as monotherapy in patients with previously treated recurrent or metastatic cervical cancer** 

● **In addition to a Phase 3 study in recurrent or metastatic cervical cancer (innovaTV 301, NCT04697628), clinical studies in other solid tumors are ongoing** 

● **Co-developed globally and co-promoted in the U.S. in collaboration with Seagen** 

Tisotumab vedotin is an ADC composed of Genmab's human monoclonal antibody directed to TF and Seagen's ADC technology that utilizes a protease-cleavable linker that covalently attaches the microtubule-disrupting agent monomethyl auristatin E to the antibody. Genmab used technology licensed from Medarex to generate the TF antibody forming part of tisotumab vedotin. Tisotumab vedotin, marketed as Tivdak, is the first and only U.S. FDA approved ADC for the treatment of adult patients with recurrent or metastatic cervical cancer with disease progression on or after chemotherapy. Tisotumab vedotin is being co-developed by Genmab and Seagen. Under a joint commercialization agreement, Genmab is co-promoting Tivdak in the U.S. and will lead commercial operational activities in Japan. Seagen is leading commercial operational activities in the U.S. and will lead commercial operational activities in Europe and China. In these four markets there will be a 50:50 cost and profit split. In other markets, Seagen will commercialize Tivdak and Genmab will receive royalties based on a percentage of aggregate net sales ranging from the mid-teens to the mid-twenties. The companies have joint decision-making on the worldwide development and commercialization strategy for Tivdak. Please refer to Note 5.6 of the financial statements for further details regarding the tisotumab vedotin collaboration with Seagen. The companies have a broad clinical development program for tisotumab vedotin, including a confirmatory Phase 3 study in recurrent or metastatic cervical cancer.

Please consult the U.S. Prescribing Information for Tivdak for the labeled indication and safety information, including the boxed warning.

**KEY ONGOING clinical TRIALS**

![Graphic](gmab-20221231xex99d1010.jpg)

**About Cervical Cancer**<sup>1</sup> 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· Cancer that originates in the cells lining the cervix

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· Fourth most frequently diagnosed and fourth most deadly cancer in women worldwide<sup>2</sup>

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· In developing regions, ranked second in incidence and mortality in women<sup>2</sup>

● In 2022, an estimated 14,100 new cases of invasive cervical cancer will be diagnosed, and 4,280 women will die from the disease in the U.S. <sup>3</sup>

● Up to 16% of women initially present with metastatic cervical cancer <sup>3</sup>

● Among women who present with earlier stage disease, 15%-61% will go on to develop metastatic cervical cancer, most commonly within the first two years following completion of therapy <sup>4</sup>

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| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

● 5-year survival rate for women in the U.S. and Japan with recurrent or metastatic cervical cancer is only 17.1% and 19.5%, respectively, highlighting an urgent unmet need for effective treatment <sup>3</sup>

<sup>1</sup> General statistics include all stages of cervical cancer.

<sup>2</sup> Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians. 2018;68(6):394-424.

<sup>3</sup> Institute NC. SEER Cancer Stat Facts: Cervical Cancer. 2022. https://seer.cancer.gov/statfacts/html/cervix.html. Accessed November 21, 2022.

<sup>4</sup> Pfaendler KS, Tewari KS. Changing paradigms in the systemic treatment of advanced cervical cancer. Am J Obstet Gynecol. 2016;214(1):22-30.

#### UPDATES FROM FIRST QUARTER TO THIRD QUARTER
● June: Genmab and Seagen presented multiple tisotumab vedotin abstracts at the American Society of Clinical Oncology (ASCO) Annual Meeting, including interim data from the Phase 1b/2 innovaTV 205 (NCT03786081) study of tisotumab vedotin, which was presented during an oral session. The ongoing innovaTV 205 study is evaluating tisotumab vedotin as monotherapy and in combination with other agents in recurrent or metastatic cervical cancer.

● March: Genmab and Seagen presented interim data from two cohorts of the Phase 1b/2 innovaTV 205 study of tisotumab vedotin as a virtual oral presentation at the Society of Gynecologic Oncology Annual Meeting on Women's Cancer.

● February: Genmab and Seagen presented preliminary data from the Phase 2 innovaTV 207 (NCT03485209) study of tisotumab vedotin as part of a plenary session at the American Society for Radiation Oncology (ASTRO) 2022 Multidisciplinary Head and Neck Cancers Symposium. The ongoing innovaTV 207 study is evaluating the activity, safety and tolerability of tisotumab vedotin in selected solid tumors with high TF expression. The data presented at ASTRO was from the squamous cell carcinoma of the head and neck (SCCHN) cohort of the study, which is evaluating tisotumab vedotin as monotherapy in patients with SCCHN who experienced disease progression on or after a first-line platinum-containing regimen and a checkpoint inhibitor.

#### Epcoritamab (DuoBody-CD3xCD20)

#### Potential Best-in-Class Investigational Medicine
● **Bispecific antibody-based investigational medicine created with Genmab's DuoBody technology** 

● **Multiple ongoing clinical studies across different settings and histologies, including Phase 3 studies in DLBCL (EPCORE DLBCL-1, NCT04628494) and FL (EPCORE FL-1, NCT05409066) with more studies in planning** 

● **In the second half of 2022, Genmab submitted a BLA to the U.S. FDA and a Japan New Drug Application (JNDA) to the Ministry of Health, Labor and Welfare (MHLW) in Japan for SC epcoritamab for the treatment of patients with relapsed/refractory LBCL. AbbVie submitted an MAA to the EMA for SC epcoritamab for the treatment of patients with relapsed/refractory DLBCL. The BLA was subsequently accepted for Priority Review by the U.S. FDA and the MAA was validated by the EMA. The U.S. FDA set a PDUFA date of May 21, 2023** 

● **The regulatory submissions were supported by results from the LBCL cohort of the pivotal EPCORE NHL-1 (NCT03625037) trial evaluating the safety and preliminary efficacy of epcoritamab in patients with relapsed, progressive or refractory CD20+ mature B-NHL, including DLBCL** 

● **Co-developed in collaboration with AbbVie** 

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**GENMAB 2022 ANNUAL REPORT** 

Epcoritamab is a proprietary bispecific antibody created using Genmab's DuoBody technology platform. Epcoritamab targets CD3, which is expressed on T-cells, and CD20, a clinically validated target on malignant B-cells. Genmab used technology licensed from Medarex to generate the CD20 antibody forming part of epcoritamab. In 2020, Genmab entered into a broad oncology collaboration agreement with AbbVie to jointly develop and commercialize epcoritamab. The companies will share commercial responsibilities in the U.S. and Japan, with AbbVie responsible for further global commercialization. Genmab will book sales in the U.S. and Japan and receive tiered royalties on remaining global sales outside of these territories. Please refer to Note 5.6 of the financial statements for further details regarding the epcoritamab collaboration with AbbVie. The companies have a broad clinical development program for epcoritamab, including two Phase 3 studies ongoing, and additional studies in planning.

#### FOURTH QUARTER UPDATES
● December: Publication in the *Journal of Clinical Oncology*, "Epcoritamab, a Novel, Subcutaneous CD3xCD20 Bispecific T-Cell–Engaging Antibody, in Relapsed or Refractory Large B-Cell Lymphoma: Dose Expansion in a Phase I/II Trial."

● December: Genmab submitted to the MHLW a JNDA for SC epcoritamab for the treatment of patients with relapsed/refractory LBCL after two or more lines of systemic therapy.

● December: Multiple presentations at the 64 <sup>th</sup> American Society of Hematology (ASH) Annual Meeting, including four oral presentations.

● November: The U.S. FDA accepted the BLA for SC epcoritamab for Priority Review. The U.S. FDA set a PDUFA date of May 21, 2023. Based on Genmab's agreement with AbbVie this event triggered a milestone payment of USD 80 million to Genmab.

● October: AbbVie submitted an MAA to the EMA for SC epcoritamab for the treatment of patients with relapsed/refractory DLBCL after two or more lines of systemic therapy. This was subsequently validated by the EMA , an event that triggered a milestone payment of USD 60 million to Genmab .

#### UPDATES FROM FIRST QUARTER TO THIRD QUARTER
● September: Genmab submitted a BLA to the U.S. FDA for SC epcoritamab for the treatment of patients with relapsed/refractory LBCL after two or more lines of systemic therapy.

● June: Genmab and AbbVie presented multiple epcoritamab abstracts at both the ASCO Annual Meeting and the 27th Annual Meeting of the European Hematology Association (EHA). Data from the first cohort of the EPCORE NHL-1 trial of epcoritamab in relapsed/refractory LBCL was presented as a late-breaking oral presentation during the Presidential Symposium at EHA.

● April: Genmab and AbbVie announced topline results from the first cohort of the Phase 1/2 EPCORE NHL-1 trial of epcoritamab in relapsed/refractory LBCL.

● March: The U.S. FDA granted orphan-drug designation to epcoritamab for the treatment of FL.

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**GENMAB 2022 ANNUAL REPORT** 

**Key ongoing clinical Trials**![Graphic](gmab-20221231xex99d1011.jpg)

**About Diffuse Large B-cell Lymphoma** 

● DLBCL is an aggressive type of NHL that develops from B cells <sup>1</sup>

● DLBCL is the most common type of NHL in the U.S. and worldwide <sup>1</sup>

● 64.6% 5-year survival rate <sup>2</sup>

● Prognosis for relapsed or refractory DLBCL patients is poor, especially for those with high-risk factors <sup>3</sup>

● For most patients with refractory DLBCL there are no curative treatment options <sup>3</sup>

<sup>1</sup>Lymphoma Research Foundation. Diffuse Large B-Cell Lymphoma. https://lymphoma.org/understanding-lymphoma/aboutlymphoma/nhl/dlbcl/ Accessed December 2, 2022.

<sup>2</sup>National Institutes of Health. SEER Cancer Stat Facts: DLBCL. https://seer.cancer.gov/statfacts/html/dlbcl.html. Accessed November 21, 2022.

<sup>3</sup>Crump, Michael, et al. "Outcomes in Refractory Diffuse Large B-Cell Lymphoma: Results from the International SCHOLAR-1 Study." Blood, American Society of Hematology, 19 Oct. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5649550/.

#### DuoBody-PD-L1x4-1BB (GEN1046/BNT311)

#### Bispecific Next-Generation Immunotherapy
● **Bispecific antibody-based investigational medicine created with Genmab's DuoBody technology platform** 

● **Clinical studies in solid tumors ongoing, including a Phase 2 study in NSCLC (NCT05117242)** 

● **Co-developed in collaboration with BioNTech** 

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**GENMAB 2022 ANNUAL REPORT** 

DuoBody-PD-L1x4-1BB is a proprietary bispecific antibody, jointly owned by Genmab and BioNTech, created using Genmab's DuoBody technology platform. It is being co-developed by Genmab and BioNTech under an agreement in which the companies share all costs and future potential profits for DuoBody-PD-L1x4-1BB on a 50:50 basis. DuoBody-PD-L1x4-1BB is designed to induce an antitumor immune response by simultaneous and complementary PD-L1 blockade and conditional 4-1BB stimulation using an inert DuoBody format. Three clinical studies in solid tumors are ongoing including a Phase 2 study of DuoBody-PD-L1x4-1BB as monotherapy or in combination with pembrolizumab in patients with recurrent metastatic NSCLC.

#### DuoBody-CD40x4-1BB (GEN1042/BNT312)

#### Potential First-in-Class Bispecific Agonistic Antibody
● **Bispecific antibody-based investigational medicine created with Genmab's DuoBody technology platform** 

● **Phase 1/2 clinical study (NCT04083599) in solid tumors ongoing** 

● **Co-developed in collaboration with BioNTech** 

DuoBody-CD40x4-1BB is a proprietary bispecific antibody, jointly owned by Genmab and BioNTech, created using Genmab's DuoBody technology platform. It is being co-developed by Genmab and BioNTech under an agreement in which the companies share all costs and future potential profits for DuoBody-CD40x4-1BB on a 50:50 basis. CD40 and 4-1BB were selected as targets to enhance both dendritic cells and antigen-dependent T-cell activation, using an inert DuoBody format. A Phase 1/2 clinical study of DuoBody-CD40x4-1BB in solid tumors is ongoing.

#### FOURTH QUARTER UPDATE
● December: Combination safety data and early encouraging anti-tumor activity in SCCHN patients treated with chemotherapy, pembrolizumab and DuoBody-CD40x4-1BB was presented at the European Society for Medical Oncology Immuno-Oncology Annual Congress.

#### DuoHexaBody-CD37 (GEN3009)

#### First DuoHexaBody Program in Clinical Development
● **Antibody-based investigational medicine created with Genmab's DuoHexaBody technology platform** 

● **Phase 1/2 clinical study (NCT04358458) in hematologic malignancies ongoing** 

**DuoHexaBody-CD37 is a bispecific antibody that targets two non-overlapping CD37 epitopes, created using Genmab's DuoHexaBody technology platform. The DuoHexaBody technology platform combines the dual targeting of our DuoBody technology platform with the enhanced potency of our HexaBody technology platform, creating bispecific antibodies with target-mediated enhanced hexamerization. A Phase 1/2 clinical study in hematologic malignancies, including the potential for combination with epcoritamab, is ongoing.** 

#### UPDATE FROM FIRST QUARTER TO THIRD QUARTER
● June: AbbVie decided to discontinue co-development of DuoHexaBody-CD37. Upon expiry of the 180-day notice period on December 24, 2022, Genmab became solely responsible for the further

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**GENMAB 2022 ANNUAL REPORT** 

development of DuoHexaBody-CD37 against low-single digit royalty payments to AbbVie, up to an agreed maximum total royalty amount, based on future potential sales of the product.

#### HexaBody-CD38 (GEN3014)

#### HexaBody-based Investigational Medicine with Potential in Hematological Malignancies
● **Antibody-based investigational medicine created with Genmab's HexaBody technology platform** 

● **Phase 1/2 clinical study (NCT04824794) in hematological malignancies ongoing** 

● **Developed in an exclusive worldwide license and option agreement with Janssen** 

**HexaBody-CD38 is a human CD38 monoclonal antibody-based investigational medicine created using Genmab's HexaBody technology platform. In pre-clinical models of hematological malignancies, HexaBody-CD38 demonstrated highly potent complement-dependent cytotoxicity and showed potent anti-tumor activity. In June 2019, Genmab entered into an exclusive worldwide license and option agreement with Janssen to develop and commercialize HexaBody-CD38. A Phase 1/2 clinical study in hematologic malignancies is ongoing and includes an arm comparing HexaBody-CD38 to daratumumab in anti-CD38 monoclonal antibody-naïve relapsed or refractory multiple myeloma patients.**

#### FOURTH QUARTER UPDATE
● December: Poster presentation of preliminary dose-escalation results presented at the 64 <sup>th</sup> ASH Annual Meeting.

#### DuoBody-CD3xB7H4 (GEN1047)

#### Bispecific with Potential in Solid Tumors
● **Bispecific antibody-based investigational medicine created with Genmab's DuoBody technology platform** 

● **Phase 1/2 clinical study (NCT05180474) in malignant solid tumors ongoing** 

DuoBody-CD3xB7H4 is a bispecific antibody-based investigational medicine created using Genmab's DuoBody technology platform. B7H4 is an immune checkpoint protein expressed on malignant cells in various solid cancers including breast, ovarian and lung cancer. In pre-clinical studies, DuoBody-CD3xB7H4 induced T-cell mediated cytotoxicity of B7H4-positive tumor cells. DuoBody-CD3xB7H4 is being developed for the potential treatment of solid cancer indications known to express B7H4. A Phase 1/2 clinical study of DuoBody-CD3xB7H4 in malignant solid tumors is ongoing.

#### UPDATE FROM FIRST QUARTER TO THIRD QUARTER
● January: The first patient was dosed in the first-in-human Phase 1/2 study of DuoBody-CD3xB7H4 in patients with malignant solid tumors.

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**GENMAB 2022 ANNUAL REPORT** 

**HexaBody-CD27 (GEN1053/BNT313)**

#### HexaBody-based Investigational Medicine with Potential in Solid Tumors
● **Antibody-based investigational medicine created with Genmab's HexaBody technology platform** 

● **Phase 1/2 clinical study (NCT05435339) in solid tumors ongoing** 

● **Co-developed in collaboration with BioNTech** 

HexaBody-CD27 is a CD27 antibody that utilizes Genmab's HexaBody technology, specifically engineered to form an antibody hexamer (a formation of six antibodies) upon binding its target on the cell membrane of T cells. It is being co-developed by Genmab and BioNTech under an agreement in which the companies share all costs and future potential profits for HexaBody-CD27 on a 50:50 basis. A Phase 1/2 clinical study of HexaBody-CD27 in solid tumors is ongoing.

#### FOURTH QUARTER UPDATEs
● November: The first patient was dosed in the first-in-human Phase 1/2 study of HexaBody-CD27 in patients with malignant solid tumors.

● November: First pre-clinical disclosure during the Society for Immunotherapy of Cancer 37 <sup>th</sup> Annual Meeting.

**UPDATE FROM FIRST QUARTER TO THIRD QUARTER**

● May: IND application and first Clinical Trial Application (CTA) submitted for HexaBody-CD27.

**GEN1056 (BNT322)**

#### First-in-Human Study Recruiting
● **Phase 1 clinical study (NCT05586321) in solid tumors ongoing** 

● **Co-developed in collaboration with BioNTech** 

GEN1056 is an antibody product being co-developed by Genmab and BioNTech for the treatment of solid tumors and for use in combination with other products. A first-in-human Phase 1 clinical study of GEN1056 in patients with advanced solid tumors is ongoing.

#### FOURTH QUARTER UPDATE
● November: The first patient was dosed in the first-in-human Phase 1 study of GEN1056.

#### UPDATE FROM FIRST QUARTER TO THIRD QUARTER
● July: The first CTA was submitted for GEN1056.

### Pre-clinical Programs
● **Broad pre-clinical pipeline that includes both partnered products and in-house programs based on our proprietary technologies and/or antibodies** 

● **Multiple new INDs expected to be submitted over the coming years** 

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**GENMAB 2022 ANNUAL REPORT** 

● **Genmab has entered multiple strategic collaborations to support the expansion of our innovative pipeline** 

Our pre-clinical pipeline includes immune effector function enhanced antibodies developed with our HexaBody technology platform and bispecific antibodies created with our DuoBody technology platform. We are also collaborating with our partners to generate additional new antibody-based product concepts. A number of the pre-clinical programs are conducted in cooperation with our collaboration partners.

#### UPDATE FROM FIRST QUARTER TO THIRD QUARTER
● August: Genmab and BioNTech expanded the companies' global strategic collaboration to develop and commercialize novel immunotherapies for the treatment of cancer patients. Under the expansion, the companies will jointly develop and commercialize, subject to regulatory approval, other formats including monospecific antibodies leveraging Genmab's proprietary HexaBody technology platform.

### Approved Medicines Incorporating Genmab's Innovations and Technology

The information in this section includes those medicines that have been approved by regulatory agencies in certain territories. Under the agreements for these medicines Genmab is entitled to certain potential milestones and royalties.

#### DARZALEX (daratumumab)

#### Redefining the Treatment of Multiple Myeloma
● **First-in-class human CD38 monoclonal antibody** 

● **Developed and commercialized by Janssen under an exclusive worldwide license from Genmab** 

● **Intravenous (IV) formulation approved in combination with other therapies and as monotherapy for certain multiple myeloma indications** 

● **First and only SC CD38-directed antibody approved for the treatment of certain multiple myeloma indications, known as DARZALEX *FASPRO* in the U.S., and as DARZALEX SC in Europe** 

● **SC daratumumab is the first and only approved therapy for AL amyloidosis in the U.S., Europe and Japan** 

● **2022 net sales of DARZALEX** <sup></sup> **by Janssen were USD 7,977 million** 

Daratumumab is a human monoclonal antibody that binds with high affinity to the CD38 molecule, which is highly expressed on the surface of multiple myeloma cells and is also expressed by AL amyloidosis plasma

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**GENMAB 2022 ANNUAL REPORT** 

cells. Genmab used technology licensed from Medarex to generate the CD38 antibody. Daratumumab is being developed by Janssen under an exclusive worldwide license from Genmab to develop, manufacture and commercialize daratumumab. Under the terms of the agreement, Genmab is entitled to double digit royalties between 12% and 20% with Janssen reducing such royalty payments for Genmab's share of Janssen's royalty payments made to Halozyme. Please refer to Note 5.6 of the financial statements for further details regarding the daratumumab collaboration with Janssen. Daratumumab (marketed as DARZALEX for IV administration and as DARZALEX *FASPRO* in the U.S. and as DARZALEX SC in Europe for SC administration) is approved in a large number of territories for the treatment of adult patients with certain multiple myeloma indications and is the only approved therapy in the U.S., Europe and Japan for the treatment of adult patients with AL amyloidosis.

Please consult the European Summary of Product Characteristics for DARZALEX and DARZALEX SC and the U.S. Prescribing Information for DARZALEX and DARZALEX *FASPRO* for the labeled indication and safety information.

#### Kesimpta (ofatumumab)

#### Approved in the Treatment of RMS
● **Human CD20 monoclonal antibody developed and commercialized by Novartis under a license agreement with Genmab** 

● **Approved in territories including the U.S., EU and Japan for treatment of RMS in adults** 

● **First B-cell therapy that can be self-administered by patients at home or anywhere using the Sensoready** <sup>®</sup> **autoinjector pen** 

Ofatumumab is a human monoclonal antibody that targets an epitope on the CD20 molecule encompassing parts of the small and large extracellular loops. Genmab used technology licensed from Medarex to generate the CD20 antibody. Ofatumumab, marketed as Kesimpta, is approved in territories including the U.S., Europe and Japan for the treatment of certain adult patients with RMS. Kesimpta is the first B-cell therapy that can be self-administered by patients at home or anywhere using the Sensoready autoinjector pen, once monthly after starting therapy. Ofatumumab is being developed and marketed worldwide by Novartis under a license agreement between Genmab and Novartis. Under the terms of the agreement, Genmab is entitled to 10% royalties on net sales of Kesimpta. Please refer to Note 5.6 of the financial statements for further details regarding the ofatumumab collaboration with Novartis.

Please consult the U.S. Prescribing Information and the European Summary of Product Characteristics for the labeled indication and safety information for Kesimpta.

#### TEPEZZA (teprotumumab-trbw)
**First U.S. FDA Approved Medicine for the Treatment of TED**

● **Developed and commercialized by Horizon for the treatment of TED** 

● **First and only U.S. FDA approved medicine for the treatment of TED** 

● **Also being explored in a clinical trial for the treatment of diffuse cutaneous systemic sclerosis (dcSSC)** 

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**GENMAB 2022 ANNUAL REPORT** 

Please consult the U.S. Prescribing Information for the labeled indication and safety information for TEPEZZA.

#### RYBREVANT (amivantamab)
**First Regulatory Approvals for a DuoBody-based Medicine**

● **Part of Genmab and Janssen DuoBody research and license agreement** 

● **First approved medicine created using Genmab's proprietary DuoBody technology platform** 

● **Under the agreement with Janssen, Genmab will receive milestones and royalties on net sales of RYBREVANT** 

In July 2012, Genmab entered into a collaboration with Janssen to create and develop bispecific antibodies using Genmab's DuoBody technology platform. One of these, Janssen's amivantamab, is a fully human bispecific antibody that targets epidermal growth factor receptor (EGFR) and cMet, two validated cancer targets. The two antibody libraries used to produce amivantamab were both generated by Genmab. In collaboration with Janssen, the antibody pair used to create amivantamab was selected. Janssen is responsible for the development and commercialization of amivantamab.

In 2021, Janssen received approvals in the U.S., Europe and other markets for amivantamab, marketed as RYBREVANT, for the treatment of certain adult patients with NSCLC with EGFR exon 20 insertion mutations. These were the first regulatory approvals for a therapy that was created using Genmab's proprietary DuoBody bispecific technology platform. Under our agreement with Janssen, Genmab will receive milestones and royalties between 8% and 10% on net sales of RYBREVANT. Please refer to Note 5.6 of the financial statements for further details regarding the DuoBody collaboration with Jansen.

Please consult the U.S. Prescribing Information and the European Summary of Product Characteristics for RYBREVANT for the labeled indication and safety information.

#### TECVAYLI (teclistamab)
**Bispecific Antibody Approved for the Treatment of Relapsed and Refractory Multiple Myeloma**

● **Part of Genmab and Janssen DuoBody research and license agreement** 

● **Second approved medicine created using Genmab's proprietary DuoBody technology platform** 

● **Under the agreement with Janssen, Genmab will receive milestones and royalties on net sales of TECVAYLI** 

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**GENMAB 2022 ANNUAL REPORT** 

In July 2012, Genmab entered into a collaboration with Janssen to create and develop bispecific antibodies using Genmab's DuoBody technology platform. One of the products subsequently discovered and developed by Janssen is teclistamab, a bispecific antibody that targets CD3, which is expressed on T-cells and B-cell maturation antigen (BCMA), which is expressed on mature B lymphocytes.

In August 2022, Janssen received conditional marketing authorization from the European Commission for subcutaneously administered teclistamab, marketed as TECVAYLI, as monotherapy for the treatment of adult patients with relapsed and refractory multiple myeloma. Patients must have received at least three prior therapies, including an immunomodulatory agent, a proteasome inhibitor, and a CD38 antibody and have demonstrated disease progression on the last therapy. In October 2022, Janssen received U.S. FDA approval of TECVAYLI™ (teclistamab-cqyv) for the treatment of adult patients with relapsed or refractory multiple myeloma, who previously received four or more prior lines of therapy, including a proteasome inhibitor, immunomodulatory drug and anti-CD38 monoclonal antibody.

TECVAYLI is the second therapy created using Genmab's proprietary DuoBody bispecific technology platform to receive regulatory approval. Under our agreement with Janssen, Genmab will receive milestones and a mid-single digit royalty on net sales of TECVAYLI. Please refer to Note 5.6 of the financial statements for further details regarding the DuoBody collaboration with Jansen.

Please consult the U.S. Prescribing Information and the European Summary of Product Characteristics for TECVAYLI for the labeled indication and safety information.

### Antibody Technologies
Antibodies are Y-shaped proteins that play a central role in immunity against bacteria and viruses (also known as pathogens). As we develop immunity, our bodies generate antibodies that bind to pathogen structures (known as antigens), which are specific to the pathogen. Once bound, the antibodies attract other parts of the immune system to eliminate the pathogen. In modern medicine, we have learned how to create and develop specific antibodies against antigens associated with diseased human cells for use in the treatment of diseases such as cancer and autoimmune disease. Genmab uses several types of technologies to create antibodies to treat disease and has developed proprietary antibody technologies including the DuoBody, HexaBody, DuoHexaBody and HexElect technology platforms. Information about these technologies can be found in the following sections and at www.genmab.com/research-innovation/antibody-technology-platforms/.

We also use or license several other technologies to generate diverse libraries of high-quality, functional antibodies. In addition, we use or license technologies to increase the potency of some of our antibody therapeutics on a product-by-product basis, including ADCs. ADCs are antibodies with potent cytotoxic agents coupled to them. By using antibodies that recognize specific targets on tumor cells, these cytotoxic agents are preferentially delivered to the tumor cells.

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**GENMAB 2022 ANNUAL REPORT** 

#### Our Proprietary Technology Platform Suite

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| &nbsp;&nbsp;**Platform** |  | &nbsp;&nbsp;**Principle** | &nbsp;&nbsp;**Applications** |
| &nbsp;&nbsp;DuoBody | &nbsp;&nbsp;![Graphic](gmab-20221231xex99d1012.jpg)<br>| &nbsp;&nbsp;Bispecific antibodies | &nbsp;&nbsp;Dual-targeting:<br>· Recruitment (e.g., T cells)<br>· Tumor heterogeneity<br>|
| &nbsp;&nbsp;HexaBody | &nbsp;&nbsp;![Graphic](gmab-20221231xex99d1013.jpg)<br>| &nbsp;&nbsp;Target-mediated enhanced hexamerization | &nbsp;&nbsp;Enhanced potency:<br>· Complement-dependent cytotoxicity (CDC)<br>· Target clustering, outside-in signaling, apoptosis<br>|
| &nbsp;&nbsp;DuoHexaBody | &nbsp;&nbsp;![Graphic](gmab-20221231xex99d1014.jpg)<br>| &nbsp;&nbsp;Bispecific antibodies with target-mediated enhanced hexamerization | &nbsp;&nbsp;Dual-targeting + enhanced potency:<br>· CDC<br>· Target clustering, outside-in signaling, apoptosis<br>|
| &nbsp;&nbsp;HexElect | &nbsp;&nbsp;![Graphic](gmab-20221231xex99d1015.jpg)<br>| &nbsp;&nbsp;Two co-dependent antibodies with target-mediated enhanced hexamerization | &nbsp;&nbsp;Dual-targeting + enhanced potency and selectivity:<br>· Co-dependent unlocking of potency<br>· New target space, previously inaccessible<br>|

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#### DuoBody Technology Platform

#### Innovative Technology for Bispecific Antibody Therapeutics
● **Bispecific antibody technology platform** 

● **Potential in cancer, autoimmune, infectious, cardiovascular, central nervous system diseases and hemophilia** 

● **Commercial collaborations with AbbVie, Janssen and BioNTech among others, plus multiple research collaborations** 

● **First regulatory approvals for medicines created using the DuoBody technology platform – Janssen's RYBREVANT and TECVAYLI** 

● **In the second half of 2022, Genmab submitted a BLA to the U.S. FDA and a JNDA to the MHLW for SC epcoritamab for the treatment of patients with relapsed/refractory LBCL. AbbVie submitted an MAA to the EMA for SC epcoritamab for the treatment of patients with relapsed/refractory DLBCL** 

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| Kalvebod Brygge 43 |  | Page 33/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

The DuoBody technology platform is Genmab's innovative platform for the discovery and development of bispecific antibodies. Bispecific antibodies bind to two different epitopes (or "docking" sites) either on the same or on different targets (also known as dual-targeting). Dual-targeting may improve binding specificity and enhance therapeutic efficacy or bring two different cells together (for example, engaging a T cell to kill a tumor cell). Bispecific antibodies generated with the DuoBody technology platform can be used for the development of therapeutics for diseases such as cancer, autoimmune, infectious, cardiovascular, central nervous system diseases and hemophilia. DuoBody molecules combine the benefits of bispecificity with the strengths of conventional antibodies, which allows DuoBody molecules to be administered and dosed the same way as other antibody therapeutics. Genmab's DuoBody technology platform generates bispecific antibodies via a versatile and broadly applicable process that is easily performed at high throughput, standard bench, as well as at commercial manufacturing scale. Genmab uses the DuoBody technology platform to create its own bispecific antibody programs and the technology is also available for licensing. Genmab has numerous alliances for the DuoBody technology platform including commercial collaborations with AbbVie, Janssen, Novo Nordisk, BioNTech and Immatics.

Genmab's proprietary DuoBody technology platform has been applied to a variety of bispecific antibody products in development, both in our own pipeline and in programs being developed by collaboration partners. The technology has been validated by the continued advancement of these investigational medicines through clinical development, including two medicines approved in both the U.S. and in Europe.

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|:---|
| &nbsp;&nbsp;v<br>|
| &nbsp;&nbsp;<br>The innovative DuoBody technology platform generates bispecific antibodies via a fast, versatile and broadly applicable process called controlled Fab-arm exchange. With only minimal protein engineering, the technology allows the binding arms of two distinct monoclonal antibodies to exchange, combining into one stable bispecific antibody, thereby retaining regular immunoglobulin structure and function. The DuoBody technology platform is also highly suitable for high throughput generation, screening and discovery of bispecific antibodies in final therapeutic format.<br>|

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**DuoBody Collaborations** 

**Advancing Our Pipeline**

**AbbVie**

On June 10, 2020, Genmab entered into a broad oncology collaboration agreement with AbbVie to jointly develop and commercialize products including epcoritamab (DuoBody-CD3xCD20), and subsequently into a discovery research collaboration for up to four future differentiated antibody therapeutics for cancer. The companies will share commercial responsibilities for epcoritamab in the U.S. and Japan, with AbbVie responsible for further global commercialization. Genmab will be the principal for net sales in the U.S. and Japan and will receive tiered royalties on remaining global sales outside of these territories. For any product candidates developed as a result of the companies' discovery research collaboration, Genmab and AbbVie will share responsibilities for global development and commercialization in the U.S. and Japan. Genmab retains the right to co-commercialize these products, along with AbbVie, outside of the U.S. and Japan.

Under the terms of the agreement, Genmab has the potential to receive regulatory and sales milestone payments, as well as tiered royalties between 22% and 26% on net sales for epcoritamab outside the U.S. and Japan. Except for these royalty-bearing sales, the parties will share in pre-tax profits from the potential sale of epcoritamab on a 50:50 basis. If all four next-generation antibody product candidates developed as a

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| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 34/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

result of the discovery research collaboration are successful, Genmab is eligible to receive up to USD 2.0 billion in option exercise and success-based milestones. Genmab and AbbVie split 50:50 the development costs related to epcoritamab, while Genmab will be responsible for 100% of the costs for the discovery research programs up to opt-in. Please refer to Note 5.6 of the financial statements for further details regarding the collaboration with AbbVie.

**BioNTech** 

In May 2015, Genmab entered an agreement with BioNTech to jointly research, develop and commercialize bispecific antibody-based investigational medicines using Genmab's DuoBody technology platform. Under the terms of the agreement, BioNTech will provide proprietary antibodies against key immunomodulatory targets, while Genmab provides proprietary antibodies and access to its DuoBody technology platform. Genmab paid an upfront fee of USD 10 million to BioNTech. If the companies jointly select any antibody-based product candidates for clinical development, development costs and product ownership will be shared equally going forward. If one of the companies does not wish to move an antibody product forward, the other company is entitled to continue developing it on predetermined licensing terms. The agreement also includes provisions which will allow the parties to opt out of joint development at key points. Genmab and BioNTech selected two antibody products for clinical development, DuoBody-CD40x4-1BB (GEN1042/BNT312) and DuoBody-PD-L1x4-1BB (GEN1046/BNT311), both of which are now in clinical trials.

**Our Innovative Technology in Action**

**Janssen**

In July 2012, Genmab entered into a collaboration with Janssen to create and develop bispecific antibodies using our DuoBody technology platform. Under this original agreement, Janssen had the right to use the DuoBody technology platform to create panels of bispecific antibodies (up to 10 DuoBody programs) to multiple disease target combinations.

As of December 31, 2022, three DuoBody-based investigational medicines created under this collaboration were in the clinic. Two of these, amivantamab and teclistamab, are the first medicines created using the DuoBody technology platform to receive regulatory approval. In December 2022, Janssen submitted a BLA to the U.S. FDA for the third investigational medicine in active clinical development, talquetamab, for the treatment of patients with relapsed or refractory multiple myeloma. Genmab is entitled to milestone payments as well as royalties on sales of each commercialized DuoBody medicine. Please refer to Note 5.6 of the financial statements for further details regarding the DuoBody collaboration with Janssen.

**Novo Nordisk**

In August 2015, Genmab entered an agreement to grant Novo Nordisk commercial licenses to use the DuoBody technology platform to create and develop bispecific antibody candidates for two therapeutic programs that would target a disease area outside of cancer therapeutics. After an initial period of exclusivity for both target combinations, Novo Nordisk extended exclusivity of the commercial license for one target combination in 2018, now in clinical development as Mim8. Under the exclusive license agreement, Genmab is entitled to potential milestones and will be entitled to single digit royalties on sales of Mim8, should it receive regulatory approval.

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| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 35/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

**Collaborations Across the Pharma and Biotech Ecosystem**

**Immatics** 

In July 2018, Genmab entered into a research collaboration and exclusive license agreement with Immatics to discover and develop next-generation bispecific immunotherapies to target multiple cancer indications. Genmab received an exclusive license to three proprietary targets from Immatics, with an option to license up to two additional targets at predetermined economics. Under the terms of the agreement, Genmab paid Immatics an upfront fee of USD 54 million and Immatics is eligible to receive up to USD 550 million in development, regulatory and commercial milestone payments for each antibody product, as well as tiered royalties on net sales.

#### HexaBody Technology Platform

#### Creating Differentiated Therapeutics
● **Enhanced potency antibody technology platform** 

● **Broadly applicable technology that builds on natural antibody biology** 

● **HexaBody-based investigational medicines in clinical development; HexaBody-CD38 (GEN3014) and HexaBody-CD27 (GEN1053/BNT313)** 

The HexaBody technology platform is a proprietary Genmab technology that is designed to increase the potency of antibodies. The HexaBody technology platform builds on natural biology and strengthens the natural killing ability of antibodies while retaining regular structure and specificity. The technology allows for the creation of potent therapeutics by inducing antibody hexamer formation (clusters of six antibodies) after binding to their target antigen on the cell surface. We have used the HexaBody technology platform to generate antibodies with enhanced complement-mediated killing, allowing antibodies with limited or absent killing capacity to be transformed into potent, cytotoxic antibodies. In addition to complement-mediated killing, the clustering of membrane receptors by the HexaBody technology platform can lead to subsequent outside-in signaling leading to cell death. The HexaBody technology platform creates opportunities to explore new antibody-based product candidates and repurpose drug candidates unsuccessful in previous clinical trials due to insufficient potency. The HexaBody technology platform is broadly applicable and can be combined with Genmab's DuoBody technology platform (DuoHexaBody technology platform) as well as other antibody technologies. The technology has the potential to enhance antibody therapeutics for a broad range of applications including cancer and infectious diseases. Genmab is using the HexaBody technology platform for its own antibody programs and the technology is also available for licensing. Two HexaBody-based investigational medicines are currently in clinical development. Genmab entered into an exclusive worldwide license and option agreement with Janssen to develop and commercialize HexaBody-CD38 (GEN3014), a next-generation CD38 monoclonal antibody-based investigational medicine. In 2022, Genmab and BioNTech expanded their global strategic collaboration to include co-development of monospecific antibody candidates leveraging the HexaBody technology. The first antibody in the clinic under this collaboration is HexaBody-CD27 (GEN1053/BNT313).

#### DuoHexaBody Technology Platform

#### Combining Dual-Targeting and Enhanced Potency
● **Antibody technology that combines DuoBody and HexaBody technology platforms** 

● **Creates bispecific antibodies with target-mediated enhanced potency** 

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| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 36/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

● **First DuoHexaBody-based investigational medicine in the clinic - DuoHexaBody-CD37 (GEN3009)** 

The DuoHexaBody technology platform is a proprietary technology that combines the dual targeting of our DuoBody technology platform with the enhanced potency of our HexaBody technology platform, creating bispecific antibodies with target-mediated enhanced hexamerization. We currently have one investigational medicine created with the DuoHexaBody technology platform in the clinic, DuoHexaBody-CD37 (GEN3009). DuoHexaBody-CD37 is a bispecific antibody that targets two non-overlapping CD37 epitopes. It entered the clinic in 2020 and is currently being investigated in relapsed/refractory B-NHL, including potentially in combination with epcoritamab.

#### HexElect Technology Platform Enhancing Selectivity and Potency
● **Antibody technology platform inspired by the HexaBody technology platform** 

● **Combines dual-targeting with enhanced selectivity and potency** 

The HexElect antibody technology platform is Genmab's newest proprietary antibody technology. This technology combines two HexaBody molecules designed to effectively and selectively hit only those cells that express both targets by making the activity of complexes of HexaBody molecules dependent on their binding to two different targets on the same cell. The HexElect technology platform maximizes efficacy while minimizing possible toxicity, potentially leading to more potent and safer investigational medicines.

### Corporate Social Responsibility and Sustainability Commitments
We are committed to being a sustainable, socially responsible biotech company. This commitment is anchored in our vision, core purpose and values, focused for impact through our CSR strategy, and lived every day by our team. It is fundamental to the way we do business.

**Our Core Purpose and Vision**

Our commitment to CSR is anchored in our company's core purpose "to improve the lives of patients by creating and developing innovative antibody products" and our vision that "by 2030, our KYSO antibody medicines will fundamentally transform the lives of people with cancer and other serious diseases." Our vision inspires and motivates us. Our unstoppable team is focused on developing innovative and differentiated antibody therapeutics that will improve the lives of patients.

**How We Carry Out Our CSR Initiatives**

We are committed to complying with all laws, codes, and standards applicable to our business and operations. We also prioritize the well-being and vitality of our teams and actively seek to minimize our impact on the environment. We have high ethical standards and aim to conduct business with companies and within countries that share our ethical commitment including our support for the protection of internationally proclaimed human rights. We strive to conduct clinical trials in markets where a medicine is planned to become available.

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| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 37/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

We track trends, benchmark and examine our ESG activities, policies and disclosures to build a sustainable, socially responsible biotech company.

We are committed to transparency and continued improvement of our climate disclosures. To this end, we support the TCFD recommendations as we believe they provide a useful framework to increase transparency on climate-related risks and opportunities. We want to reduce our environmental footprint and aim to provide additional disclosures on climate-related topics in the future as we incorporate the TCFD recommendations into our business. Please refer to "Genmab's Task Force on Climate-related Financial Disclosures" in this report for more information.

We follow the Sustainability Accounting Standards Board (SASB) framework to disclose critical measurements on ESG activities relevant to our business.

We are committed to ensuring our actions benefit our direct stakeholders (patients, customers, team members, collaboration partners and shareholders) and society as a whole.

To this end, our CSR strategy focuses on four key pillars:

● Science-Driven Health Innovations for Patients

● Employee Well-Being and Vitality

● Ethics and Transparency

● Environmental and Community Sustainability

As we further execute our CSR strategy and build programs that have an impact on our stakeholders, we will be guided by the following tenets, which support our four CSR pillars:

● We use our world-class knowledge in antibody biology and deep expertise in innovative antibody technology to develop cancer treatments to have a positive impact on society.

● We care for our employees' health, well-being, safety and development and promote a collaborative culture that fosters passion for innovation, integrity and respect.

● We believe that DE&I are fundamental to achieving our vision and are committed to championing a corporate culture that accepts and promotes uniqueness and empowers each team member to bring their authentic self to work in a safe, open and respectful environment.

● We operate our business with the utmost integrity, seeking to do the right thing in all aspects of our business and integrating compliance, ethics and transparency into our business practices, policies and procedures.

● We maintain a highly ethical organization, promoting our Code of Conduct to employees and engaging with partners and suppliers committed to the same level of ethics in their operations.

● We aim to reduce our impact on the environment by refining our processes and incorporating best practices into our operations as we strive to reduce our environmental footprint, minimize waste and decrease use of hazardous material.

● We monitor and evaluate targets for ESG activities, measure our impact and communicate our progress.

● We engage with and support the communities in which we operate.

**Our Approach**

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| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 38/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

Our approach is designed to ensure we carry out our CSR commitments as a core part of our business and in line with international best practice.

● Guided by our vision, purpose and core values

● Focused on four CSR pillars

● Underpinned by our commitment to the UNSDGs

● Supported by the Board of Directors and Executive Management

● Aligned with ESG priorities and disclosures

**CSR Governance**

Our CSR governance is led by the Board of Directors. Our Board of Directors' Nominating and Corporate Governance Committee oversees our CSR efforts and provides recommendations to the Board on corporate responsibility and sustainability matters. Additionally, the Board of Directors' Audit and Finance Committee oversees our ESG reporting requirements.

Our CSR Committee, which is co-chaired by our CEO and the Senior Vice President of Global Communications and Corporate Affairs, provides direction on CSR strategy and associated policies and ensures we carry out our CSR activities effectively and communicate them clearly and openly. Our CSR Global Council and Global Sustainability Working Group help us implement and enhance our CSR strategy.

**Our Commitment to the United Nations Sustainable Development Goals**

As a company rooted in science, inspired by patients, and committed to sustainability, we embrace our responsibility to society and are proud to help advance the UNSDGs. An initial internal assessment in 2020 determined that our business activities were most closely aligned with Goals 3, 5 and 8. In 2022, based on our commitment and actions regarding climate change, we decided to add Goal 13: Climate Action. We focus on aligning our CSR activities to support these goals and will continue to assess our business operations in relation to all the UNSDGs.

**Goal 3: Good Health and Well-Being: Ensure healthy lives and promote well-being for all at all ages** 

We are dedicated to using science-driven innovation to improve the lives of patients with cancer and their families. In addition to dedicating resources to research and development and to bring medicines to patients, we are committed to our employees' well-being and vitality, and have benefits and programs in place for them. Additionally, we seek to support and be part of health-related initiatives in the communities where we operate.

**Goal 5: Gender Equality: Achieve gender equality and empower all women and girls** 

We continue to lead in gender diversity among our peers. We have a female representation at "Director-level and above" of 51% and are proud that nearly half of our Board of Directors are female, including the Chair and Deputy Chair.

**Goal 8: Decent Work and Economic Growth: Promote sustained, inclusive and sustainable economic growth, full and productive employment and decent work for all** 

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| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 39/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

Our work is driven by innovation and conducted by highly skilled people dedicated to their roles. We pay all our team members a living wage and provide a safe, inclusive and secure working environment. Additionally, we contribute to the life sciences innovation ecosystem by collaborating with academia, biotech and pharma companies, and other innovators to advance therapies against cancer and other diseases. We also contribute to science, technology, engineering, and mathematics (STEM) education, mentoring programs and other community efforts to help advance education and professional development among our communities.

**Goal 13: Climate Action: Take urgent action to combat climate change and its impacts**

We are committed to transparency and continued improvement of our climate disclosures. In 2022, we committed to supporting the recommendations of the TCFD. Our journey to reduce our impact on the environment inspired our work to establish a climate target to reduce our GHG emissions in line with the Paris Agreement to align our business to a future where global warming is kept at or below 1.5°C. We measure and report on emissions from our own operations and from purchased electricity and have begun the process of designing a model to collect data across our value chain for our Scope 3 emissions.

**Genmab's statutory report on Corporate Responsibility for the financial year 2022 cf. Sections 99a, 99b, 99d and 107d of the Danish Financial Statements Act ("Lovpligtig redegørelse for samfundsansvar, jf. årsregnskabslovens § 99 a, 99b, 99d, 107d") can be found on the company's website (https://ir.genmab.com/static-files/72218610-90a6-4fd3-a76a-d4a7c9c6ef01), including additional information about policies, progress made during 2022 and expected activities for 2023.** 

**Genmab's Task Force on Climate-related Financial Disclosures**

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| &nbsp;&nbsp;Sustainable growth and a focus on our environmental impact are key to Genmab's evolution into a fully integrated biotechnology powerhouse. <br>|  |  |
| &nbsp;&nbsp;Topic | &nbsp;&nbsp;Recommended Disclosures | &nbsp;&nbsp;Genmab's Disclosures |
| &nbsp;&nbsp;Governance | &nbsp;&nbsp;Describe the board's oversight of climate-related risks and opportunities. | &nbsp;&nbsp;The Board of Directors' Nominating and Corporate Governance Committee oversees climate-related issues as part of its responsibility over all aspects of Genmab's CSR strategy. The Committee and the Board of Directors receive biannual updates on Genmab's progress, related risks and opportunities. |
|  | &nbsp;&nbsp;Describe management's role in assessing and managing climate-related risks and opportunities. | &nbsp;&nbsp;The CSR Committee moves our CSR efforts forward and integrates ESG-related matters relevant to our business into our strategic planning.<br>From 2022, the CSR Committee will receive updates on Genmab's progress toward carbon reduction targets, climate-related financial risk, relevant prevention and mitigation measures annually.<br>Climate-related financial risks and relevant prevention and mitigation measures will be reviewed and endorsed by the Global Compliance and Risk Committee. Additionally, the Audit and Finance Committee oversees our ESG reporting requirements. |

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| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 40/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

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| &nbsp;&nbsp;Strategy | &nbsp;&nbsp;Describe the climate-related risks and opportunities the<br>organization has identified over the short, medium and long term.<br>Describe the impact of<br>climate-related risks and<br>opportunities on the<br>organization's businesses,<br>strategy and financial<br>planning. | &nbsp;&nbsp;Genmab has conducted scenario analysis on the potential transition and physical risks and opportunities related to climate change, at 1.5 - 2°C and 4°C of warming, across our value chain, in the short term (2030), and medium/long term (2040/2050). Below is a brief summary of the key potential risks identified:<br>Description of potential risks identified 1.5 - 2°C, short term:<br>● Transition risk resulting from emerging certification, regulation and carbon taxation, pricing, and tariffs and related costs of compliance and the switch to low carbon materials and technologies<br>● Transition risk resulting from increased focus of investors and regulators on ESG performance in investment decision-making, increasingly connecting access to capital and investment to ESG and climate performance<br>● Transition risk resulting from shift in consumer preferences and talent attraction criteria toward climate and responsibility <br>● Physical risk of disruption of supply chains due to changes in weather patterns and extreme weather events <br>● Physical risk resulting from more frequent and severe heat waves, leading to increased cooling costs<br>Description of potential risks identified 1.5 - 2°C, medium/ long term<br>● Physical risk of disruption of supply chains and operations due to changes in weather patterns and increase in frequency of extreme weather events<br>● Physical risk resulting from more frequent and severe heat waves, leading to increased cooling costs<br>● Physical risk resulting from coastal flooding, potentially disrupting operations and the supply chain<br>Description of potential risks identified 4°C, short term<br>● Physical risk of disruption of supply chains, acute limited supply, and increased cost of raw materials due to changes in weather patterns and extreme weather events<br>|

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| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 41/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

 ● Physical risk resulting from frequent and severe heat waves, leading to increased cooling costs ● Physical risk of disruption of supply chain, operations and distribution, resulting from increased acute flooding Description of potential risks identified 4°C, medium/long term ● Transition risk resulting from fragmented regulatory efforts to curb runaway climate change through cost of compliance with carbon taxation, pricing, etc. ● Physical risk resulting from acute, severe and frequent extreme weather events, leading to disruption of operations, supply chain and distribution, damage to physical assets and inventory, as well as increase in raw materials cost and insurance costs ● Physical risk resulting from acute and severe heat waves, leading to instability of supply chains, increased energy costs for cooling and loss of inventory ● Physical risk resulting from sea level rise and coastal flooding, leading to disruption of operations and supply chains, damage to physical assets, inventory

Describe the climate-related risks and opportunities the organization has identified over the short, medium and long term.Describe the impact ofclimate-related risks andopportunities on the organization's businesses,strategy and financial planning. Brief summary of the key potential climate related opportunities: Description of potential opportunities identified 1.5 – 2°C and 4°C &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; ● Cost savings from the use of new technologies, more energy efficient/low carbon production and distribution &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; ● Cost savings and reduced exposure to resource and water scarcity through, for instance, the use of recycling &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; ● Increase resilience, adaptation and cost savings from efficient and green buildings &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; ● Cost savings and lowered exposure to carbon pricing and other regulations &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; ● Reputational gains with stakeholders and potential employees from focus on climate-related topics

Describe the impact ofclimate-related risks andopportunities on theorganization's businesses, Climate-related risks and opportunities identified will be considered and integrated as part of Genmab's ERM program, financial planning and strategy. To play our part in mitigating the physical impacts of climate change and

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| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 42/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

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|  | &nbsp;&nbsp;strategy and financial planning. | &nbsp;&nbsp;curbing warming, Genmab will commit to a climate target, to reduce our GHG emissions in line with the Paris Agreement. |
|  | &nbsp;&nbsp;Describe the resilience of the organization's strategy, taking into consideration different climate-related scenarios, including a 2°C or lower scenario. | &nbsp;&nbsp;Genmab has conducted qualitative climate<br>related scenario analysis. Four scenarios spanning 1.5 – 2°C and 4°C of warming were developed based on Intergovernmental Panel on Climate Change, International Energy Agency and other sources, and Genmab's risks and opportunities across the value chain in the short, medium/ long term were assessed.<br>In 2023, Genmab will further assess the resilience of our corporate strategy in these climate-related scenarios. |
| &nbsp;&nbsp;Risk Management | &nbsp;&nbsp;Describe the organization's processes for identifying and assessing climate-related risks. | &nbsp;&nbsp;In 2022, Genmab continued its assessment of climate-related risk and scenario analysis to identify key risks and opportunities. The risks have been assessed through stakeholder engagement and interviews. |
|  | &nbsp;&nbsp;Describe the organization's processes for managing climate-related risks. | &nbsp;&nbsp;Climate-related risks identified will be considered as part of our ERM program, and responsibility for monitoring, prevention and mitigation will be cascaded to relevant functions within Genmab. |
|  | &nbsp;&nbsp;Describe how processes for identifying, assessing and managing climate-related<br>risks are integrated into the organization's overall risk management. |  |
| &nbsp;&nbsp;Metrics and Targets | &nbsp;&nbsp;Disclose the metrics used by the organization to assess climate-related<br>risks and opportunities in line with its strategy and risk management process. | &nbsp;&nbsp;Genmab reports on Scope 1 and 2 GHG emissions in line with the GHG Protocol.<br>Genmab will develop metrics related to business continuity and natural disaster recovery. These may include, for instance, suppliers assessed/engaged on climate and climate risk topics, etc. |
|  | &nbsp;&nbsp;Disclose Scope 1, Scope 2 and, if appropriate, Scope 3 GHG emissions and the related risks. | &nbsp;&nbsp;Genmab's Scope 1 and 2 emissions totaled 393.8 tonnes CO<sub>2</sub>e in 2022. Emissions reductions will contribute to the mitigation of the transition risk of carbon taxes, pricing and tariffs.<br>In connection with our intent to commit to and set a climate target, Genmab started the process of measuring our Scope 3 emissions by estimating emissions from selected material Scope 3 categories. This estimation will be foundational in establishing the baseline for our climate ambitions, targets and emissions reductions. |
|  | &nbsp;&nbsp;Describe the targets used by the organization to manage climate-related | &nbsp;&nbsp;Genmab intends to commit to and set a climate target to reduce our GHG emissions in line with the Paris Agreement goals. |

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| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 43/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

<u>risks and opportunities and performance against targets.</u>

We calculated our Scope 1 and 2 emissions in accordance with the global standard for carbon accounting, the GHG Protocol, and these were reduced by 38% compared to 2021. In 2022 we initiated the process of estimating our Scope 3 footprint in accordance with the GHG Protocol. A thorough assessment of Genmab's value chain emissions based on 2021 spend-data showed us that there is a need for higher quality data. This is due to our business model, where key carbon intensive process steps for the discovery and development of our antibody-based molecules are outsourced, and a majority of revenue is generated based on royalty streams from out-licensed products. The 2022 assessment had an unacceptable uncertainty level with regards to >90% of our estimated emissions. We will continue to improve the quality of our data and we will strive to engage with our suppliers and partners in order to obtain a Scope 3 carbon footprint with an acceptable level of accuracy, acknowledging that carbon footprint mapping is inherently uncertain.

---

| | |
|:---|:---|
| &nbsp;&nbsp;**Carbon Emissions** | &nbsp;&nbsp;**2022** |
| &nbsp;&nbsp;Total Scope 1 emissions (tCO<sub>2</sub>e) | &nbsp;&nbsp;283.1 |
| &nbsp;&nbsp;Total Scope 2 emissions (tCO<sub>2</sub>e) | &nbsp;&nbsp;110.7 |
| &nbsp;&nbsp;**Total Scope 1 & 2 emissions (tCO**<sub>2</sub>**e)** | &nbsp;&nbsp;**393.8** |
| &nbsp;&nbsp;**Electricity Consumption and Renewables** | &nbsp;&nbsp;**2022** |
| &nbsp;&nbsp;Electricity consumption (MWh) | &nbsp;&nbsp;3127 |
| &nbsp;&nbsp;Share renewables  | &nbsp;&nbsp;94% |

---

**Stakeholder Engagement** 

As an international company, Genmab has many stakeholders with an interest in how we conduct our business. Continuous engagement with these groups drives our success. We do this through direct interactions, participation in industry groups, employee engagement surveys, and more. Some of Genmab's key stakeholder groups and the ways we interact with them are highlighted here.

**Our Research Collaborators**

Genmab collaborates with parties from large pharmaceutical companies to academic institutions. These are collaborations with complementary partners in terms of technologies, capabilities and knowledge.

Why are they important to us?

Collaborations across the innovation ecosystem of pharma, biotech and academia help us create innovative next-generation antibody therapeutics and potentially bring them to patients faster.

How do we engage with them?

Our methods of engagement vary from co-development of programs, licensing of our technology platforms, involvement in clinical trials and indirectly, through our work with industry groups.

Our list of research collaborations is extensive. We work with large pharmaceutical and biotechnology companies as well as other innovative companies and groups. Some examples of the latter include: Tempus, which has built one of the world's largest libraries of clinical and molecular data; the European Network of Gynecological Oncological Trial Groups and Gynecologic Oncology Group, with which we collaborated on the

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|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 44/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

tisotumab vedotin innovaTV 204 study; industry groups such as the Biotechnology Innovation Organization (BIO), Holland Bio, BioNJ and the Confederation of Danish Industry.

**Our People**

The health, well-being, safety, and development of Genmab's team members is a top priority for the organization.

Why are they important to us?

Our talented teams are the cornerstone of our success and fundamental to achieving our 2030 Vision. We believe that an engaged, inclusive and diverse workplace inspires our employees and is essential to our future.

How do we engage with them?

Genmab aims to foster individual empowerment and development and allows people to transform their skills into real value for patients.

In 2022, we conducted a global team member engagement survey, which consisted of both questionnaire and focus groups on five topics: Camaraderie & Teamwork, Career Development, Empowerment & Trust, Performance Management and Work-Life Balance. Genmab's results outpaced Life Sciences industry benchmarks and highlighted key opportunities to drive even higher engagement in the future. The survey had an 88% global participation rate and an 84% employee engagement score.

**Patient Advocacy Organizations**

With our first medicine on the market, we have an obligation to engage with patient advocates to ensure we are providing as much support as possible to patients in need.

Why are they important to us?

Transforming the lives of patients is our purpose. Supporting and collaborating with patient advocacy organizations is an important way in which Genmab can positively impact the lives of patients.

How do we engage with them?

Over the course of the past few years, we have actively sought out patient advocacy groups, both to provide our financial support for their efforts and programs and also to collaborate and bring them to our locations for educational events with the Genmab team.

In 2022 we, along with our partner Seagen, launched CeMe, a disease awareness campaign that leverages real-life storytelling to spotlight the barriers to treatment and challenges associated with cervical cancer. The campaign features diverse members of the cervical cancer community, including patients and patient advocates, in content on the CeMe YouTube channel. Social media posts encourage visits to the YouTube channel to watch the videos and seek additional information from various patient advocacy groups.

**Our Communities**

Our team members actively engage in the communities in which we operate.

Why are they important to us?

As part of Genmab's ongoing commitment to CSR we aim to be good citizens not only of the world but of the local communities in which our facilities are located.

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|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 45/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

How do we engage with them?

Throughout 2022, Genmab supported community-based activities; for example, on September 13, 2022, nearly 500 Genmab colleagues participated in the first annual Global Volunteer Day. Colleagues from Denmark, the Netherlands and the U.S. helped more than 30 nonprofit organizations in their communities. Activities included: removing invasive plants from a nature preserve, building toys for children with serious illnesses, making comfort kits for cancer patients, and assembling food kits to combat hunger in our local communities.

Colleagues can also use the Community@Genmab Portal to learn about Genmab's impact, share volunteer stories, and access the Global Employee Giving Program.

**Our Shareholders and Investors**

Genmab has a diverse shareholder base with investors from across a spectrum of size and location.

Why are they important to us?

The support of Genmab's investors is essential to the success of the Company as we grow into a fully integrated biotech innovation powerhouse.

How do we engage with them?

We communicate about our business, financial results, development programs and scientific results in an open and transparent way through company announcements, investor meetings and company presentations.

Illustrating this transparency, we maintain a dialogue with our shareholders, investors and other stakeholders, and the Board of Directors participates in ad hoc investor meetings, e.g., as part of regular corporate governance outreach campaigns to our shareholders, as well as their representatives and proxy advisors, to gain insight into the perspective of our shareholders.

More information on Genmab's stakeholder engagement may be found in our 2022 Corporate Responsibility Report on the company's website (https://ir.genmab.com/static-files/72218610-90a6-4fd3-a76a-d4a7c9c6ef01).

### Human Capital Management
Employees are Genmab's most important resource, and we strive to attract and retain the most qualified people to fulfill our core purpose. Genmab's goal is to develop and retain value in our own products which could one day transform cancer treatment. At Genmab, we have four culture pillars that inspire team members in their everyday work.

Genmab's Culture Pillars

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| | | | |
|:---|:---|:---|:---|
| &nbsp;&nbsp;Patients Come First | &nbsp;&nbsp;Rooted in Science | &nbsp;&nbsp;Act with Courage | &nbsp;&nbsp;We are 'One Genmab' |
| &nbsp;&nbsp;We are committed to making a positive impact for patients | &nbsp;&nbsp;We hypothesize and experiment to seek innovative solutions, no matter our role | &nbsp;&nbsp;We speak up, empower each other, and embrace change and grow | &nbsp;&nbsp;We respect and celebrate our differences while working as One Team |

---

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|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 46/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

Teamwork and respect are central pillars of Genmab's culture, and we therefore ensure an inclusive, open and supportive professional work environment across our international locations. We believe that fostering workplace diversity across social, educational, cultural, national, age and gender lines is a prerequisite for the continued success of the company. We are committed to diversity at all levels of the company and strive to recruit employees with the right skills and competencies, regardless of gender, age, ethnicity and other differences.

Skill, knowledge, experience and employee motivation are essential to Genmab as a biotech company. The ability to organize our highly skilled and very experienced colleagues at all levels of the organization into interactive teams is a key factor in achieving our goals and ensuring Genmab's success.

KEY EMPLOYEE INFORMATION

---

| | | | | |
|:---|:---|:---|:---|:---|
| **Male/Female Ratios** | **2022** | **2022** | **2021** | **2021** |
|  | **Male** | **Female** | **Male** | **Female** |
| Genmab Group | 42% | 58% | 42% | 58% |
| Director level and above | 49% | 51% | 49% | 51% |
| Below director level | 37% | 63% | 38% | 62% |
| Annual promotions<sup>1</sup> | 40% | 60% | 39% | 61% |

---

---

| | | |
|:---|:---|:---|
| **Other Employee Information**  | **2022** | **2021** |
| FTE at the end of the year | 1660 | 1212 |
| Research and development FTE | 1193 | 927 |
| Selling, general and administrative FTE  | 467 | 285 |
| FTE in Denmark at the end of the year | 385 | 312 |
| FTE in the Netherlands at the end of the year | 575 | 437 |
| FTE in the US at the end of the year | 642 | 420 |
| FTE in Japan at the end of the year | 58 | 43 |
| Employee turnover<sup>2</sup> | 7% | 6% |
| Employee absence<sup>3</sup> | 2% | 2% |

---

<sup>1</sup> Annual promotions are calculated as FTE promotions occurring during the respective years.

<sup>2</sup> Employee turnover percentage is calculated by the FTE voluntarily leaving since the beginning of the year divided by the average FTE.

<sup>3</sup> The rate of absence is measured as absence due to the employee's own illness, pregnancy-related sick leave and occupational injuries and illnesses compared with a regional standard average of working days in the year, adjusted for holidays.

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| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 47/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

**"As we look back at 2022, the strength of Genmab's financial profile really stands out. Our strong balance sheet, growing recurring revenues and significant underlying profitability have allowed us, and will continue to allow us, to strategically invest in our business and our pipeline."** 

Anthony Pagano, Executive Vice President and Chief Financial Officer

### Financial Review
The financial statements are prepared on a consolidated basis for Genmab A/S (parent company) and its subsidiaries. The Genmab financial statements are published in Danish Kroner (DKK). The Genmab consolidated Group is referenced herein as "Genmab" or the "Company".

#### RESULT FOR THE YEAR

---

| | | |
|:---|:---|:---|
| **Guidance and Result for 2022**  | **Guidance and Result for 2022**  | **Guidance and Result for 2022**  |
| **(DKK million)** | **Latest Guidance** | **Actual** |
| Revenue | 13500 - 14500 | 14595 |
| Operating expenses | (8000) - (8400) | (8238) |
| Operating profit | 5100 - 6500 | 6357 |

---

Actual revenue was favorable to guidance primarily due to higher than anticipated milestone revenue and slightly favorable USD/DKK foreign exchange rate movements. Operating expenses and operating profit were in line with the latest guidance published on November 9, 2022.

#### REVENUE
Genmab's revenue was DKK 14,595 million in 2022 compared to DKK 8,482 million in 2021. The increase of DKK 6,113 million, or 72%, was primarily driven by higher DARZALEX and Kesimpta royalties achieved under our collaborations with Janssen and Novartis, respectively, due to higher net sales and higher average exchange rate between the USD and DKK, and milestones achieved in 2022 under our collaboration with AbbVie.

![Graphic](gmab-20221231xex99d1017.jpg)![Graphic](gmab-20221231xex99d1018.jpg)

#### Royalties
Royalty revenue amounted to DKK 11,672 million in 2022 compared to DKK 6,977 million in 2021. The increase of DKK 4,695 million, or 67%, was primarily driven by higher DARZALEX, Kesimpta and TEPEZZA royalties achieved under our daratumumab collaboration with Janssen, ofatumumab collaboration with Novartis, and teprotumumab collaboration with Roche, respectively. The following table summarizes Genmab's royalty revenue by product.

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|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 48/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;**(DKK million)** | **2022** | **2021** |
| &nbsp;&nbsp;DARZALEX  | 10056 | 6135 |
| &nbsp;&nbsp;TEPEZZA  | 796 | 593 |
| &nbsp;&nbsp;Kesimpta  | 779 | 235 |
| &nbsp;&nbsp;Other | 41 | 14 |
| &nbsp;&nbsp;**Total royalties** | **11672** | **6977** |

---

Net sales of DARZALEX by Janssen were USD 7,977 million in 2022 compared to USD 6,023 million in 2021. The increase of USD 1,954 million, or 32%, was driven by share gains, continued strong market growth and uptake of the DARZALEX SC product. Royalty revenue on net sales of DARZALEX was DKK 10,056 million in 2022 compared to DKK 6,135 million in 2021, an increase of DKK 3,921 million. The percentage increase in royalties of 64% is higher than the percentage increase in the underlying net sales primarily due to the higher average exchange rate between the USD and DKK, other positive foreign exchange rate impacts, and a higher effective royalty rate for 2022, partly offset by the increase in Genmab's share of Janssen's royalty payments to Halozyme in connection with SC product net sales. Under our license agreement with Janssen for DARZALEX, for purposes of calculating royalties due to Genmab, DARZALEX net sales for non-U.S. dollar denominated currencies are translated to U.S. dollars at a specified annual Currency Hedge Rate. This contractual arrangement is the driver for the other foreign exchange impacts discussed above.

Royalty revenue on net sales of TEPEZZA was DKK 796 million in 2022 compared to DKK 593 million in 2021, an increase of DKK 203 million, or 34%. TEPEZZA net sales in the first quarter of 2021 were negatively impacted by the U.S. government-mandated COVID-19 production interruption.

Net sales of Kesimpta by Novartis were USD 1,092 million in 2022 compared to USD 372 million in 2021. The increase of USD 720 million was driven strong launch uptake, access and increased demand. Royalty revenue on net sales of Kesimpta was DKK 779 million in 2022 compared to DKK 235 million in 2021, an increase of DKK 544 million.

Janssen was granted U.S. FDA approval for RYBREVANT during the second quarter of 2021, and Genmab subsequently started recognizing royalties on net sales of RYBREVANT. Royalties were not material for 2022 or 2021.

Janssen was granted approval for TECVAYLI for the treatment of relapsed or refractory multiple myeloma during the third quarter of 2022 in Europe and in the fourth quarter of 2022 in the U.S. Royalties were not material for 2022.

Royalty revenue fluctuations from period to period are driven by the level of product net sales, foreign currency exchange rate movements and more specifically to DARZALEX, the contractual arrangement related to annual Currency Hedge Rate, and Genmab's share of Janssen's royalty payments to Halozyme in connection with SC product net sales.

#### Reimbursement Revenue
Reimbursement revenue, mainly comprised of the reimbursement of certain research and development costs related to the development work under Genmab's collaboration agreements, amounted to DKK 818 million in 2022 compared to DKK 531 million in 2021. The increase of DKK 287 million, or 54%, was primarily driven by higher activities under our collaboration agreements with BioNTech for HexaBody-CD27 and DuoBody-CD40x4-1BB.

**Milestone Revenue**

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| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 49/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

Milestone revenue was DKK 1,767 million in 2022 compared to DKK 954 million in 2021, an increase of DKK 813 million, or 85%, primarily driven by the following:

● AbbVie milestone of DKK 577 million (USD 80 million) driven by the acceptance of the BLA by the U.S. FDA for epcoritamab,

● AbbVie milestone of DKK 444 million (USD 60 million) triggered by the validation of the MAA by the EMA in the EU for epcoritamab,

● Janssen milestones of DKK 189 million (USD 25 million) and DKK 112 million (USD 15 million) for the approval of TECVAYLI for the treatment of relapsed or refractory multiple myeloma in the U.S. and Europe, respectively, and

● AbbVie milestone of DKK 153 million (USD 20 million) driven by the initiation, or first patient dosed, of a pivotal trial (Phase 3) in the second indication for epcoritamab.

The increase in milestone revenue in 2022 was partly offset by milestones achieved in 2021 under our Janssen and AbbVie collaborations.

Milestone revenue may fluctuate significantly from period to period due to both the timing of achievements and the varying amount of each individual milestone under our license and collaboration agreements.

**Collaboration Revenue**

In September 2021, Genmab and Seagen announced U.S. FDA accelerated approval for Tivdak in previously treated recurrent or metastatic cervical cancer. Collaboration revenue was DKK 332 million in 2022 compared to DKK 20 million in 2021. The increase of DKK 312 million was primarily driven by increased sales of Tivdak and also includes a one-off payment due from Seagen of DKK 112 million (approximately USD 15 million) which reflects Genmab's share (50%) of payments received by Seagen in connection with the sublicense of its rights to develop and commercialize tisotumab vedotin in China to Zai Lab Hong Kong pursuant to Genmab's Joint Commercialization Agreement with Seagen.

Refer to Note 2.1 for further details about revenue.

#### OPERATING EXPENSES
Total operating expenses increased by DKK 2,774 million, or 51%, from DKK 5,464 million in 2021 to DKK 8,238 million in 2022.

#### Research and Development Expenses
Research and development expenses amounted to DKK 5,562 million in 2022 compared to DKK 4,181 million in 2021. The increase of DKK 1,381 million, or 33% was driven by the continued advancement of our product pipeline including epcoritamab under our collaboration with AbbVie, and DuoBody-CD40x4-1BB under our collaboration with BioNTech, and the increase in team members to support the expansion of our product pipeline.

Research and development costs accounted for 68% of the total operating expenses in 2022 compared to 77% in 2021.

The following table provides information regarding our research and development expenses for 2022 as compared to 2021.

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|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 50/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

---

| | | | |
|:---|:---|:---|:---|
| |  |  | **Percentage** <br>**Change** |
| <br>**(DKK million)** | **2022** | **2021** | **2022/2021** |
| Research(1) | 1222 | 958 | 28% |
| Development and contract manufacturing(2)  | 1556 | 1374 | 13% |
| Clinical(3)  | 2059 | 1360 | 51% |
| Upfront payments(4) | 155 | 61 | 154% |
| Other(5)  | 570 | 428 | 33% |
| **Total research and development expenses** | **5562** | **4181** | **33%** |

---

(1) Research expenses include, among other things, personnel, occupancy and laboratory expenses, technology access fees associated with identification of new monoclonal antibodies (mAbs), expenses associated with the development of new proprietary technologies and research activities associated with our product candidates, such as in vitro and in vivo studies, translational research, and IND enabling toxicology studies.

(2) Development and contract manufacturing expenses include personnel and occupancy expenses, external contract manufacturing costs for the scaleup and pre-approval manufacturing of drug product used in research and our clinical trials, costs for drug product supplied to our collaborators, costs related to preparation for the production of process validation batches to be used in potential future regulatory submissions, quality control and assurance activities, and storage and shipment of our product candidates.

(3) Clinical expenses include personnel, travel, occupancy costs, and external clinical trial costs including contract research organizations (CROs), investigator fees, clinical site fees, contractors and regulatory activities associated with conducting human clinical trials.

(4) Upfront payments include payments made to third parties upon entering into R&D license and collaboration agreements.

(5) Other research and development expenses primarily include share-based compensation, depreciation, amortization and impairment expenses.

The following table shows third-party costs incurred for research, contract manufacturing of our product candidates and clinical and regulatory services for 2022 as compared to 2021. The table also presents unallocated costs and overhead consisting of third-party costs for our pre-clinical stage programs, personnel, facilities and other indirect costs not directly charged to development programs.

---

| | | | |
|:---|:---|:---|:---|
| |  |  | **Percentage** <br>**Change** |
| <br>**(DKK million)** | **2022** | **2021** | **2022/2021** |
| Epcoritamab | 1115 | 654 | 70% |
| Tisotumab vedotin | 319 | 365 | (13)% |
| DuoBody-PD-L1x4-1BB  | 369 | 371 | (1)% |
| DuoBody-CD40x4-1BB  | 242 | 135 | 79% |
| Other clinical stage programs | 419 | 250 | 68% |
| **Total third-party costs for clinical stage programs** | **2464** | **1775** | **39%** |
| Pre-clinical projects | 830 | 779 | 7% |
| Upfront payments | 155 | 61 | 154% |
| Personnel, unallocated costs and overhead | 2113 | 1566 | 35% |
| **Total research and development expenses** | **5562** | **4181** | **33%** |

---

Third-party costs for epcoritamab increased by DKK 461 million, or 70%, in 2022 as compared to 2021, primarily due to the advancement of the program to late-stage development under Genmab's collaboration with AbbVie.

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|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 51/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

Third-party costs for tisotumab vedotin decreased by DKK 46 million, or 13%, in 2022 as compared to 2021, primarily due to the completion of some clinical studies in 2022.

Third-party costs for DuoBody-PD-L1x4-1BB remained flat in 2022 compared to 2021 as development of this program continues under Genmab's collaboration with BioNTech.

Third-party costs for DuoBody-CD40x4-1BB increased by DKK 107 million, or 79%, in 2022 as compared to 2021, primarily due to the continued advancement and expansion of the program under Genmab's collaboration with BioNTech.

Third-party costs for Genmab's other clinical stage programs increased by DKK 169 million, or 68%, in 2022 as compared to 2021, primarily related to HexaBody-CD27, DuoBody-CD3xB7H4 and GEN1056 entering the clinical stage in 2022.

Research and development expenses related to our pre-clinical projects increased by DKK 51 million, or 7%, in 2022 as compared to 2021, driven by the continued investment in and number of pre-clinical programs.

Upfront payments increased by DKK 94 million, or 154%, driven by an increase in the number of R&D license payments in 2022 as compared to 2021.

Personnel, unallocated costs and overhead increased by DKK 547 million, or 35%, in 2022 as compared to 2021, primarily due to an increase in staffing levels and the expansion of our facilities to accommodate our growth. Our research and development FTEs increased from 927 at the end of 2021 to 1,193 at the end of 2022.

#### Selling, General and Administrative Expenses
Selling, general and administrative expenses were DKK 2,676 million in 2022 compared to DKK 1,283 million in 2021. The increase of DKK 1,393 million, or 109%, was driven by the increase in team members to support Tivdak post launch, continued expansion of Genmab's commercialization capabilities in support of future launches including the potential launch of epcoritamab, and investment in broader organizational infrastructure, including our technology portfolio.

DKK 1,065 million, or 40% of selling, general and administrative expenses in 2022, was related to compensation of Genmab team members involved in selling, general and administrative activities, as compared to DKK 529 million, or 41% in 2021.

Selling, general and administrative expenses accounted for 32% of the total operating expenses in 2022 compared to 23% in 2021.

#### OPERATING PROFIT
Operating profit was DKK 6,357 million in 2022 compared to DKK 3,018 million in 2021, an increase of DKK 3,339 million, or 111%.

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|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 52/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### NET FINANCIAL ITEMS
Net financial items were comprised of the following:

---

| | | |
|:---|:---|:---|
| **(DKK million)** | **2022** | **2021** |
| **Financial income:** |  |  |
| Interest and other financial income | 324 | 197 |
| Foreign exchange rate gain, net | 1034 | 1470 |
| **Total financial income** | **1358** | **1667** |
| **Financial expenses:** |  |  |
| Interest and other financial expenses | (21) | (13) |
| Loss on marketable securities, net | (361) | (246) |
| Loss on other investments, net | (298) | (443) |
| **Total financial expenses** | **(680)** | **(702)** |
| **Net financial items** | **678** | **965** |

---

Net financial items decreased by DKK 287 million, or 30%, which were primarily driven by:

● Foreign exchange movements impacting Genmab's USD denominated marketable securities and cash and cash equivalents; in particular, the USD/DKK foreign exchange rate increased 8% from year-end 2020 to year-end 2021 as compared to only 6% from year-end 2021 to year-end 2022,

● Loss on marketable securities driven by higher interest rates on Genmab's Danish mortgage investments in 2022 as compared to 2021, partly offset by,

● Lower loss on other investments in 2022 as compared to 2021 driven primarily by the decrease in fair value of Genmab's investment in common shares of CureVac, and

● Increase in interest income due to higher effective interest rates in the U.S., Europe and Denmark in 2022 as compared to 2021.

Refer to Notes 4.2 and 4.5 for further details regarding foreign currency risk and net financial items, respectively.

#### CORPORATE TAX
Corporate tax expense for 2022 was DKK 1,513 million compared to DKK 975 million for 2021. The increase in corporate tax expense is primarily the result of Genmab's higher net profit before tax. The effective tax rate in 2022 was 21.5% compared to 24.5% in 2021. The decrease in Genmab's effective tax rate was mainly driven by the ability to offset current taxable income through the deduction of capitalized R&D costs in the Netherlands and utilization of U.S. net operating loss carryforwards.

Refer to Note 2.4 for additional information regarding the corporate tax and deferred tax assets including management's significant judgements and estimates.

#### NET PROFIT
Net profit for 2022 was DKK 5,522 million compared to DKK 3,008 million in 2021. The increase of DKK 2,514 million, or 84%, was driven by the items described above.

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|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 53/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### Liquidity and Capital Resources

---

| | | | |
|:---|:---|:---|:---|
|  |  | **December 31,**  | **December 31,**  |
| &nbsp;&nbsp;**(DKK million)** |  | **2022** | **2021** |
| &nbsp;&nbsp;Marketable securities |  | 12,431 | 10,381 |
| &nbsp;&nbsp;Cash and cash equivalents |  | 9,893 | 8,957 |
| &nbsp;&nbsp;Shareholders' equity |  | 27,441 | 22,196 |

---

As of December 31, 2022 and December 31, 2021, cash and cash equivalents and marketable securities denominated in USD represented 86% of Genmab's total cash and cash equivalents and marketable securities.

Marketable securities are invested in highly secure and liquid investments with short effective maturities. As of December 31, 2022, 75% of Genmab's marketable securities were long-term A rated or higher, or short-term rated A-1 / P-1 by S&P, Moody's or Fitch compared to 68% as of December 31, 2021.

As of December 31, 2022, DKK 9,893 million, as compared to DKK 8,957 million as of December 31, 2021, was held as cash and cash equivalents, and DKK 12,431 million, as compared to DKK 10,381 million as of December 31, 2021, was held as liquid investments in short-term government and other debt instruments.

Cash and cash equivalents included short-term marketable securities of DKK 594 million at the end of December 2022, compared to DKK 296 million at the end of December 2021. In accordance with Genmab's accounting policy, securities purchased with a maturity of less than 90 days at the date of acquisition are classified as cash and cash equivalents.

Genmab requires cash to meet our operating expenses and capital expenditures. We have funded our cash requirements since inception, including through December 31, 2022, primarily with royalty and milestone payments from our partners, upfront payments and equity financing. Genmab expects to continue to fund a significant portion of our development costs for proprietary product candidates as well as commercialization activities with cash received from royalties and milestone payments from partners.

Genmab's expenditures on current and future pre-clinical and clinical development programs are subject to numerous uncertainties in timing and cost to completion. In order to advance our product candidates toward commercialization, the product candidates are tested in numerous pre-clinical safety, toxicology and efficacy studies. Genmab then conducts clinical trials for those product candidates that take several years or more to complete. The length of time varies substantially based upon the type, complexity, novelty and intended use of a product candidate. The cost of clinical trials may vary significantly over the life of a project as a result of a variety of factors, including: the number of patients required in the clinical trials; the length of time required to enroll trial participants; the number and location of sites included in the trials; the costs of producing supplies of the product candidates needed for clinical trials and regulatory submissions; the safety and efficacy profile of the product candidate; the use of CROs to assist with the management of the trials; and the costs and timing of, and the ability to secure, regulatory approvals.

Genmab's expenses also fluctuate from period to period based on the degree of collaborative activities, timing of manufacturing campaigns, numbers of patients enrolled in clinical trials and the outcome of each clinical trial event. As a result, the Company is unable to determine with any degree of certainty the anticipated completion dates, duration and completion costs of research and development projects, or when and to what extent Genmab will receive cash inflows from the commercialization and sale of any product candidates. The Company also cannot predict the actual amount or timing of future royalties and milestone payments, and these may differ from estimates. Further, as the global COVID-19 pandemic has continued to

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| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

evolve, there may be long-term impacts on the development, regulatory approval and commercialization of our product candidates and on net sales of our approved products by our collaboration partners.

Genmab expects to make additional capital outlays and to increase operating expenditures over the next several years as the Company hires additional employees, supports pre-clinical development, manufacturing, clinical trial activities, product collaborations and commercialization activities. As spending increases on research, development and commercialization activities related to product collaborations, Genmab may be required to make certain capital outlays against which Genmab expects to receive reimbursement to the extent the outlay exceeds Genmab's share under the applicable collaboration agreement. The Company expects that the time-lag between the expenditure by us, on the one hand, and the reimbursement by a partner of its relevant share, on the other hand, will increase Genmab's working capital needs. To the extent the Company's capital resources are insufficient to meet future capital requirements, Genmab will need to finance operating requirements and cash needs through public or private equity offerings, debt financings, or additional corporate collaboration and licensing arrangements.

Refer to Notes 4.2 and 4.4 for additional information regarding our financial risks and marketable securities, respectively.

#### Cash Flows
The following table provides information regarding Genmab's cash flow for 2022 and 2021.

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| | | |
|:---|:---|:---|
| **Cash Flow (DKK million)** | **2022** | **2021** |
| Cash provided by operating activities | 3912 | 2228 |
| Cash (used in) investing activities | (2761) | (961) |
| Cash (used in) / provided by financing activities | (789) | (420) |
| **Increase in cash and cash equivalents** | **362** | **847** |
| Exchange rate adjustments | 574 | 850 |

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Net cash provided by operating activities is primarily related to our operating profit, changes in operating assets and liabilities, reversal of net financial items, and adjustments related to non-cash transactions. Cash provided by operating activities increased compared to 2021 primarily driven by an increase in operating profit of DKK 3,339 million, partly offset by AbbVie milestones achieved during the fourth quarter of 2022 that were uncollected at year-end 2022 of DKK 1.1 billion, and an increase in corporate tax payments of DKK 841 million due to higher net profit before tax.

Net cash (used in) investing activities primarily reflects differences between the proceeds received from the sale and maturity of our investments and amounts invested, and the cash paid for investments in tangible assets. Purchases of marketable securities exceeded sales and maturities to a greater extent in 2022 compared to 2021. In 2021, investing activities also include the proceeds from the sale of CureVac shares of DKK 438 million. There were no sales of other investments in 2022.

Net cash (used in) financing activities is primarily related to the purchase of treasury shares, exercise of warrants, lease payments, and payment of withholding taxes on behalf of employees on net settled Restricted Stock Units (RSUs). The increase in cash used in financing activities for the periods is primarily driven by cash payments for the purchase of treasury shares of DKK 908 million in 2022 compared to DKK 447 million in 2021.

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| Kalvebod Brygge 43 |  | Page 55/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

Exchange rate adjustments represent foreign currency gains or losses on Genmab's cash and cash equivalents, primarily driven by our cash and cash equivalents holdings denominated in USD. The USD/DKK foreign exchange rate increased 8% in 2021 as compared to only 6% in 2022.

#### BALANCE SHEET
As of December 31, 2022, total assets were DKK 30,278 million, compared to DKK 24,627 million as of December 31, 2021. As of December 31, 2022, assets are mainly comprised of marketable securities of DKK 12,431 million, cash and cash equivalents of DKK 9,893 million, and current receivables of DKK 5,910 million. The receivables consist primarily of amounts related to royalties, milestones, and reimbursement revenue from our collaboration agreements. The credit risk related to our receivables is not significant based on the high-quality nature of Genmab's collaboration partners.

Refer to Note 3.5 for additional information regarding receivables.

As of December 31, 2022, total liabilities were DKK 2,837 million compared to DKK 2,431 million as of December 31, 2021. The increase in total liabilities of DKK 406 million, or 17%, was driven by an increase in other payables of DKK 234 million primarily related to accrued compensation as a result of team growth from 2021 to 2022, and lease liabilities of DKK 172 million related to the commencement of leases in the Netherlands in 2022.

Shareholders' equity as of December 31, 2022 was DKK 27,441 million compared to DKK 22,196 million as of December 31, 2021. The increase of DKK 5,245 million, or 24%, was driven primarily by Genmab's net profit and share-based compensation expense related to the issuance of shares under Genmab's warrant and RSU programs, partly offset by the purchase of treasury shares during the period. Genmab's equity ratio was 91% as of December 31, 2022 compared to 90% as of December 31, 2021.

#### LEGAL MATTERS – JANSSEN BINDING ARBITRATIONS
In September 2020, Genmab commenced binding arbitration of two matters arising under its license agreement with Janssen relating to daratumumab. Under the license agreement, Genmab is, among other things, entitled to royalties from Janssen on net sales of daratumumab (marketed as DARZALEX for IV administration and as DARZALEX *FASPRO* in the U.S. and as DARZALEX SC in Europe for SC administration). In April 2022, the arbitral tribunal issued an award in the binding arbitration of the two matters. Genmab did not seek a review of the award, and the award is now final.

The first matter concerned the question as to whether Janssen's obligation to pay royalties on sales of licensed product extends, in each applicable country, until the expiration or invalidation of the last-to-expire relevant Genmab-owned patent or the last-to-expire relevant Janssen-owned patent covering the product, as further defined and described in the license agreement. As to that matter, the tribunal determined by majority opinion that Janssen's obligation to pay royalties to Genmab on sales of licensed product, in each applicable country, extends through the expiration or invalidation of the last-to-expire relevant Genmab-owned patent covering the product or use thereof, but not the relevant Janssen-owned patent. The relevant Genmab-owned issued U.S., European and Japanese patents will expire in the late 2020s and early 2030s.

The second matter concerned the question as to whether Genmab is required to share in Janssen's royalty payments to Halozyme for the Halozyme enzyme technology used in the SC formulation of daratumumab (marketed as DARZALEX *FASPRO* in the U.S.). The royalties Janssen pays to Halozyme represent a mid-single digit percentage rate of SC daratumumab sales. As to that matter, the tribunal ruled by majority opinion that Janssen is permitted to continue reducing its royalty payments to Genmab as an offset against a share of Janssen's royalty payments made to Halozyme.

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| Kalvebod Brygge 43 |  | Page 56/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

On June 9, 2022, Genmab announced the commencement of a second arbitration under the daratumumab license agreement with Janssen. This second arbitration follows from the award in the prior arbitration, where the tribunal ruled in favor of Janssen on the question as to whether Genmab is required to share in Janssen's royalty payments to Halozyme for its technology used in the daratumumab SC product. The tribunal based its ruling on the finding that DARZALEX *FASPRO* constitutes a new licensed product under the license agreement.

In this second arbitration, Genmab is consequently seeking an award of USD 405 million plus interest in accrued milestone payments for DARZALEX *FASPRO* and a declaration that it is entitled to a new 13-year royalty term from the date of DARZALEX *FASPRO*'s first commercial sale. See Company Announcement no. 21/2022.

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|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 57/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

**Risk Management**

Genmab has core facilities in four countries and performs research and development activities with clinical trials conducted around the globe. We have also begun to commercialize medicines. Through our activities, we are exposed to a variety of risks, some of which are inherent in our business and/or beyond our control. These risks may have a significant impact on our business if not properly assessed and controlled. Maintaining a strong control environment, with adequate procedures for identification and assessment of risks and adhering to operational policies designed to reduce such risks to an acceptable level, is essential for the continued evolution of Genmab. It is our policy to identify and reduce the risks derived from our operations and to establish insurance coverage and other risk reduction and resilience mechanisms to mitigate any residual risk, wherever considered practicable. The Audit and Finance Committee of the Board of Directors performs a yearly review of Genmab's Enterprise Risk Program and relevant insurance coverage to ensure that they are appropriate. For further information about the risks and uncertainties that Genmab faces, refer to the current Form 20-F filed with the SEC.

The use of Data, as defined in the Danish Financial Statements Act, both personal and non-personal, is essential to fulfilling Genmab's core purpose; and Genmab is committed to handling Data with integrity and in an ethical and compliant manner considering the impact our actions may have on individuals and society.

During 2022, Genmab has developed a policy for Data Ethics in light of Section 99d of the Danish Financial Statements Act in which Genmab adopts the Data Ethics principles of the International Federation of Pharmaceutical Manufacturers & Associations (IFPMA).

These principles complement and strengthen already existing Genmab policies and procedures, and they focus on the following areas:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. **Autonomy:** Respect individuals' privacy, protect their rights, and honor confidentiality

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. **Transparency:** Individuals should be able to understand how their personal Data is used

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3. **Data Quality:** The best quality Data available should be used to make decisions

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4. **Fairness and Non-discrimination:** Data acquisition should be inclusive, equitable, and seek to support the industry's mission of responding to the needs of all patients

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5. **Ethics by Design:** Controls to prevent harm and risks to individuals should be built into the design of Data architecture and Data processing

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6. **Responsible Data Sharing:** Data sharing should be based on processes that actively and consistently consider, prioritize, and protect individual rights

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7. **Responsibility and Accountability:** Data Ethics Principles should be operationalized through effective governance, clear standards, training, monitoring activities, and disciplinary sanctions

The Genmab Data Ethics policy has been communicated to our management for further distribution and consideration within Genmab's various departments. During 2023, Genmab will focus on further embedding these principles into its operations, particularly in the areas of data privacy, DE&I, clinical trials, and the application of new technologies (e.g., Artificial Intelligence and Machine Learning), where policies, processes, and training materials will be aligned with the above-mentioned principles. Going forward, the Genmab Data Ethics policy and its principles will be anchored in the Genmab Code of Conduct as part of the overall Genmab Compliance program.

The following is a summary of Genmab's key risk areas and how we address and mitigate such risks. Environmental and ethical risks are also covered in Genmab's statutory report on Corporate Responsibility.

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|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 58/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

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| | | | |
|:---|:---|:---|:---|
| &nbsp;&nbsp;**Risk related to** <br><BORDER_TOP> | &nbsp;&nbsp;**Risk areas**<br><BORDER_TOP> | &nbsp;&nbsp;**Mitigation**<br><BORDER_TOP> | &nbsp;&nbsp;**Risk trend**<br><BORDER_TOP> |
| &nbsp;&nbsp;**Business and Products** | &nbsp;&nbsp;The identification and development of successful products is expensive and includes time-consuming clinical trials with uncertain outcomes and the risk of failure to obtain regulatory approval in one or more jurisdictions. | &nbsp;&nbsp;Genmab has a disciplined approach to investment, focusing on areas with the potential to maximize success, including new technologies and formats, scaling up to expand from early- to late-stage development and commercialization. Genmab has established various committees to ensure optimal selection of disease targets and formats of our antibody candidates, and to monitor progress of pre-clinical and clinical development. We strive to have a well-balanced product pipeline and continue to identify and search for new product candidates and closely follow the market. | &nbsp;&nbsp;= |
|  | &nbsp;&nbsp;Genmab is dependent on the identification and development of new proprietary technologies and access to new third-party technologies. This exposes us to safety issues as well as other failures and setbacks related to use of such new or existing technologies. | &nbsp;&nbsp;Genmab continually strives to identify and develop new technologies, such as the DuoBody, HexaBody, DuoHexaBody and HexElect technology platforms, and gain access to competitive and complementary new third-party technologies such as ADC technology and messenger ribonucleic acid (mRNA) technology. We closely monitor our pre-clinical programs and clinical trials to mitigate any unforeseen safety issues or other failures, or setbacks associated with the use of our proprietary technology platforms, ADC technology or mRNA technology. | &nbsp;&nbsp;= |
|  | &nbsp;&nbsp;Genmab faces ongoing uncertainty about the successful commercialization of product candidates. This is a result of factors including immense competition on the basis of cost and efficacy as well as rapid technological change, which may result in others discovering, developing or commercializing competing products before and/or more successfully than us.  | &nbsp;&nbsp;From early in the research phase and throughout development, commercial potential and product commercialization, associated risks are assessed to ensure that final products have the potential to be commercially viable. Genmab attempts to control commercial risks in part by regularly monitoring and evaluating current market conditions, competing products and new technologies, to potentially gain access to new technologies and products that may supplement our pipeline. Genmab also strives to ensure market exclusivity for its own technologies and products by seeking patent protection.  | &nbsp;&nbsp;> |
|  | &nbsp;&nbsp;Genmab's near- and mid-term prospects are substantially dependent on continued clinical and commercial success of DARZALEX. <br>DARZALEX is subject to intense competition in the multiple myeloma therapy market. | &nbsp;&nbsp;Genmab focuses on its three-pronged strategy of focusing on our core competence, turning science into medicine and building a profitable and successful biotech to develop a broad pipeline of unique best-in-class or first-in-class antibody products with significant commercial potential. In addition, Genmab maintains a strong cash position, disciplined financial management, and a flexible and capital efficient business model to mitigate potential setbacks related to DARZALEX. <br>In 2020, two additional Genmab-created antibody products, Kesimpta and TEPEZZA, were approved by the U.S. FDA. In 2021 and 2022, respectively, the first and second DuoBody-based medicines, RYBREVANT and TECVAYLI, were approved by the U.S. FDA and the European Commission. All of these provide Genmab with additional recurring royalty revenue. Tivdak, Genmab's first medicine, in development with Seagen, was approved by the U.S. FDA and product sales of Tivdak commenced in 2021.  | &nbsp;&nbsp;= |
|  | &nbsp;&nbsp;Genmab has exposure to product liability claims related to the use or misuse of our products and technologies. | &nbsp;&nbsp;Product liability claims and/or litigation could materially affect our business and financial position, and Genmab therefore strives to maintain robust internal processes for the review, approval, and compliant use of promotion materials and also maintains appropriate product liability insurance for our clinical trials and our approved products and other coverage required under applicable laws.  | &nbsp;&nbsp;= |

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|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 59/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

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| | | | |
|:---|:---|:---|:---|
| ('&nbsp;&nbsp;<br>', '&nbsp;&nbsp;**Risk related to** <br><BORDER_TOP>') | ('&nbsp;&nbsp;<br>', '&nbsp;&nbsp;**Risk areas**<br><BORDER_TOP>') | ('&nbsp;&nbsp;<br>', '&nbsp;&nbsp;**Mitigation**<br><BORDER_TOP>') | ('&nbsp;&nbsp;<br>', '&nbsp;&nbsp;**Risk trend**<br><BORDER_TOP>') |
|  | &nbsp;&nbsp;Our core research and manufacturing activities are carried out at a limited number of locations. Any event resulting in Genmab's or our vendors'/ suppliers' inability to operate these facilities could materially disrupt our business.  | &nbsp;&nbsp;Genmab employs oversight and quality risk management principles. In addition, Genmab follows Good Laboratory Practices (GLP), Good Manufacturing Practices (GMP) and requires that our vendors operate with the same standards. Genmab has established a quality assurance (QA) department to set high-quality standards and monitor adherence to these Practices.  | &nbsp;&nbsp;> |
|  | &nbsp;&nbsp;If we are unable to effectively manage Genmab's continued fast-paced growth or build our commercialization and other capabilities, our business, financial condition and net profits may be adversely affected. Any business disruption or failure to properly manage this continued growth and transformation in a manner that reflects and supports our organizational strategies and priorities, while assuring ethical business practices, prudent risk management, and commercial compliance, could have a material adverse effect on our business, financial condition, results of operations and cash flows. | &nbsp;&nbsp;We have experienced rapid growth over the last several years, and we anticipate further growth as our pipeline advances and we move toward further commercialization of products. Such growth, including enabling new commercialization, support and other functions, has placed significant demands on our management and infrastructure, including new operational and financial systems, as well as extending manufacturing and commercial outsource arrangements. Our success will depend in part upon our ability to manage this growth effectively through leadership, focused prioritization and talent management, and maintaining our robust, values-based, collaborative culture. As we continue to grow and evolve, we must continuously improve our operational, commercial, compliance, financial and management practices and controls.  | &nbsp;&nbsp;= |
|  | &nbsp;&nbsp;Genmab is subject to government regulations on pricing/public reimbursement as well as other healthcare payer cost-containment initiatives; increased pressures by governmental and third-party payers to reduce healthcare costs. | &nbsp;&nbsp;Genmab strives to develop differentiated, cost-effective products that are well-positioned to secure reasonable price reimbursement by government healthcare programs and private health insurers. Genmab has also established a US Government Affairs & Policy department to interact with federal and state policymakers to advance policies aimed at improving patient lives through access to quality healthcare. The US Market Access department was established to educate payers on the value of our products.<br>| &nbsp;&nbsp;> |
| &nbsp;&nbsp;**Strategic Collaborations** | &nbsp;&nbsp;Genmab is dependent on existing and new partnerships with major pharmaceutical or biotech companies to support our business and develop and commercialize our products.<br>| &nbsp;&nbsp;Our business may suffer if our collaboration partners do not devote sufficient resources to our programs and products, do not successfully maintain, defend and enforce their intellectual property rights or do not otherwise have the ability to successfully develop or commercialize our products, independently or in collaboration with others. Our business may also suffer if we are not able to continue our current collaborations or establish new collaborations. Genmab strives to be an attractive and respected collaboration partner, and to pursue a close and open dialogue with our collaboration partners to share ideas and align on best practices and decisions within clinical development and commercialization to increase the likelihood that we reach our goals.  | &nbsp;&nbsp;= |
|  | &nbsp;&nbsp;Genmab is primarily dependent on one contract manufacturing organization to produce and supply our product candidates. Genmab is also dependent on clinical research organizations to conduct key aspects of our clinical trials, and on collaboration partners to conduct some of our clinical trials.  | &nbsp;&nbsp;Genmab oversees outsourcing and partnership relationships to ensure consistency with strategic objectives and service provider compliance with regulatory requirements, resources and performance. This includes assessment of contingency plans, availability of alternative service providers and costs and resources required to switch service providers. We continually evaluate financial solvency and require our suppliers to abide by a code of conduct consistent with Genmab's Code of Conduct.  | &nbsp;&nbsp;= |

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| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 60/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

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| | | | |
|:---|:---|:---|:---|
| &nbsp;&nbsp;**Risk related to** <br><BORDER_TOP> | &nbsp;&nbsp;**Risk areas**<br><BORDER_TOP> | &nbsp;&nbsp;**Mitigation**<br><BORDER_TOP> | &nbsp;&nbsp;**Risk trend**<br><BORDER_TOP> |
| &nbsp;&nbsp;**Regulation, Legislation, and Compliance**  | &nbsp;&nbsp;Genmab is subject to extensive legislative, regulatory and other requirements both during clinical development and commercialization and post-marketing approval, including healthcare, marketing/promotion, fraud and abuse, competition/antitrust laws and regulations, as well as transparency, data protection and other requirements. <br>Genmab is subject to strict disclosure obligations under applicable laws and regulations, including the EU Market Abuse Regulation. As a consequence of the listing on the Nasdaq Global Select market, we are subject to additional U.S. regulatory requirements, including U.S. securities laws and the U.S. Foreign Corrupt Practices Act, and may become more exposed to U.S. class actions.  | &nbsp;&nbsp;To ensure compliance with applicable healthcare laws and regulations, Genmab has established a robust compliance program, including a Code of Conduct that is evaluated periodically and sets high ethical standards on which all colleagues receive regular training. Also, our head of Global Compliance reports directly to the CEO. The data protection area, including policies and guidance for the processing and protection of personal data, is supported by the Company's Data Protection Officer.<br>To further support compliance with regulatory, legal and other requirements applicable to our business and operations, including current Good Laboratory Practices (cGLP), current Good Clinical Practices (cGCP) and current Good Manufacturing Practices (cGMP), Genmab has established a quality assurance department whose fuction includes staying abreast of and adhering to regulatory and legislative changes relevant to quality standards.<br>Genmab has also established relevant procedures and guidelines to ensure transparency with respect to providing timely, adequate and correct information to the market and otherwise comply with applicable securities laws and other legal and regulatory requirements. <br>Genmab has an Internal Audit function that reports to the Audit and Finance Committee of the Board of Directors and administratively reports to the CFO. | &nbsp;&nbsp;> |
|  | &nbsp;&nbsp;Legislation, regulations, industry codes and practices, and their application may change from time to time.  | &nbsp;&nbsp;To prevent unwarranted consequences of new and amended legislation, regulations, etc., Genmab strives to stay current with respect to all applicable legislation, regulations, industry codes and practices by means of its internal compliance function and related governance bodies as well as internal and external legal counsel. Also, internal procedures for review and refinement of contracts are ongoing to ensure contractual consistency and compliance with applicable legislation, regulation, and other standards.  | &nbsp;&nbsp;= |
| &nbsp;&nbsp;**Intellectual Property**  | &nbsp;&nbsp;Genmab is dependent on protecting our own intellectual property rights to regain our investments and protect our competitive positions. <br>We may become involved in lawsuits to protect or enforce our patents or other intellectual property which could result in costly litigation and unfavorable outcomes. <br>Claims may be asserted against us that we infringe the intellectual property of third parties, which could result in costly litigation and unfavorable outcomes.  | &nbsp;&nbsp;Genmab files and prosecutes patent applications to optimally protect its products and technologies. To protect trade secrets and technologies, Genmab maintains strict confidentiality standards and agreements for employees and collaborating parties. <br>Genmab actively monitors third-party patent positions within our relevant fields to avoid violating any third-party patent rights. <br>| &nbsp;&nbsp;= |
| &nbsp;&nbsp;**Finances** | &nbsp;&nbsp;Genmab may need additional funding. | &nbsp;&nbsp;Because Genmab's future commercial potential and operating profits are hard to predict, Genmab's policy is to maintain a strong capital base so as to maintain investor, creditor and market confidence, and a continuous advancement of Genmab's product pipeline and business in general.  | &nbsp;&nbsp;= |

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| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 61/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

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| | | | |
|:---|:---|:---|:---|
| &nbsp;&nbsp;**Risk related to** <br><BORDER_TOP> | &nbsp;&nbsp;**Risk areas**<br><BORDER_TOP> | &nbsp;&nbsp;**Mitigation**<br><BORDER_TOP> | &nbsp;&nbsp;**Risk trend**<br><BORDER_TOP> |
|  | &nbsp;&nbsp;Genmab is exposed to different kinds of financial risks, including currency exposure and changes in interest rates as well as changes in Danish, U.S. or foreign tax laws or related compliance requirements.<br>| &nbsp;&nbsp;Genmab has established financial risk management guidelines to identify and analyze relevant risks, to set appropriate risk limits and controls, and to monitor the risks and adherence to limits. Please refer to Note 4.2 of the financial statements for additional information regarding financial risks. | &nbsp;&nbsp;= |
| &nbsp;&nbsp;**Management and Workforce** | &nbsp;&nbsp;Genmab may have an inability to attract and retain suitably qualified team members as it continues to grow. | &nbsp;&nbsp;To attract and retain our highly skilled team, including the members of Genmab's Senior Leadership, Genmab offers competitive remuneration packages, including share-based remuneration. Genmab strives to create a positive and energizing working environment with development and training opportunities for its team members. Genmab has strong core values that nourish high-integrity and ethical behavior, respectful and candid tone and culture, as well as trust and teamwork. Please refer to Note 4.6 of the financial statements for additional information regarding share-based compensation. | &nbsp;&nbsp;> |
| &nbsp;&nbsp;**Cybersecurity**  | &nbsp;&nbsp;Genmab may be subject to malicious cyber-attacks which can lead to the theft or leakage of intellectual property, sensitive business data, or personal employee or patient data, with the result of significant business disruptions, monetary loss or fines from authorities, or reputational damage. | &nbsp;&nbsp;Genmab has implemented robust security controls and processes to enhance the identification of potential data/systems security issues and mitigate the risk of security breaches. Genmab makes use of the National Institute of Standards and Technology (NIST) Cybersecurity Framework and other security standards to define and implement such security controls. Due to the continually changing threat environment, regular assessments are executed to ensure that implemented security controls and processes follow the threat profile of the Company and effectively support Genmab's ambitious business strategy. The risk of security breaches is regarded as enterprise risk and the Company's threat profile, the security program and security incidents are presented and discussed in meetings of the Global Compliance and Risk Committee and the Audit and Finance Committee of the Board of Directors. | &nbsp;&nbsp;><br>|
| &nbsp;&nbsp;**COVID-19 Pandemic** | &nbsp;&nbsp;The global outbreak of COVID-19 has continued to evolve, may be further prolonged, and may have long-term impacts on the development, regulatory approval and commercialization of our product candidates and on net sales of our approved products. The extent, length and consequences of the pandemic are uncertain and impossible to predict. The factors discussed above, as well as other factors which are currently unanticipated or unforeseeable, may result in further and other unforeseen material adverse impacts on our business and financial performance.  | &nbsp;&nbsp;Genmab has a COVID-19 response team, led by the CEO, that monitors the situation and implements precautionary measures based on local recommendations, as necessary to help limit the impact of COVID-19 at our workplace and on our communities, and that helps ensure business continuity and mitigate effects on employee well-being. While global health authorities and global vaccination efforts alleviated some of the adverse impacts of the COVID-19 pandemic, Genmab assesses the situation on an ongoing basis in close contact with clinical trial sites, physicians and CROs to evaluate the impact and challenges posed by the COVID-19 situation and manage them accordingly. <br>| &nbsp;&nbsp;= |

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**GENMAB 2022 ANNUAL REPORT** 

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| | | | |
|:---|:---|:---|:---|
| &nbsp;&nbsp;**Risk related to** <br><BORDER_TOP> | &nbsp;&nbsp;**Risk areas**<br><BORDER_TOP> | &nbsp;&nbsp;**Mitigation**<br><BORDER_TOP> | &nbsp;&nbsp;**Risk trend**<br><BORDER_TOP> |
| &nbsp;&nbsp;**Climate** | &nbsp;&nbsp;Genmab's inability to manage the carbon footprint from our business operations; climate-related events may impact our business operations or that of our third-party partners or suppliers. | &nbsp;&nbsp;In 2022, we continued the assessment of our carbon footprint and the implementation of the TCFD recommendations. We calculated our Scope 1 and 2 emissions for 2022 in accordance with the global standard for carbon accounting, the GHG Protocol. In 2022 we also initiated the process of estimating our Scope 3 footprint in accordance with the GHG Protocol.<br>Genmab makes use of scenario analysis to evaluate our risks and opportunities due to the rapid pace of world climate change. Genmab's work with climate strategy, carbon reduction targets, climate-related financial risk, relevant prevention and mitigation measures will be presented to the Board of Directors biannually.  | &nbsp;&nbsp;= |

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Risk Level in Relation to Last Year: = Unchanged < Decreased > Increased

#### Enterprise Risk Management
As an international biotech company dedicated to improving the lives of cancer patients around the world, Genmab operates within a heavily regulated environment that exposes us to an ever-evolving set of risks, some of which are beyond our control. We maintain facilities in four countries, conduct activities in additional areas, and perform an array of essential innovation, research, development, commercialization and support functions, all of which pose risks to our operations and success. Specifically, these operations and activities expose us to risks that include but may not be limited to financial, research and development, regulatory, IT/data/technology, staffing, compliance, legal, and also environmental risks.

In order to assure that we are positioned to effectively identify and mitigate the potential impacts of these risks, Genmab has dedicated significant resources toward enabling a more robust ERM framework under the Global Compliance & Risk function that reports directly to the CEO. In concert with a refreshed Code of Conduct, company policies and procedures, Genmab has chartered a Global Compliance and Risk Governance Committee (GCRC) co-chaired by the CEO and the head of Compliance & Risk. Genmab has also updated our risk model and framework to include significantly enhanced risk oversight, mitigation, governance and reporting, all of which we believe positions us to better manage the risks associated with our business, now and into the future.

● Board of Directors and Audit and Finance Committee: Board of Directors delegates ERM/Risk oversight to the Audit and Finance Committee but retains visibility of ERM progress. The Audit and Finance Committee is accountable to ensure management appropriately manages the risks to the business.

● Executive Management: Maintains ultimate ownership of and accountability for management of top risks, enabling proper linkage of risk management to strategic initiatives and business decisions.

● GCRC: Validation of risk identification, prioritization, strategic and tactical ownership of risk mitigation plans and reporting.

● ERM Framework: Routinely gathers risks, evaluates with risk sponsors, prioritizes and reports to the GCRC, Executive Management and Board of Directors, driving deep risk discussions, and supporting risk sponsors and management in facilitating robust enterprise risk management processes, risk-intelligent decision-making and key risk capabilities.

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**GENMAB 2022 ANNUAL REPORT** 

● Risk Sponsors and Business Champions: Manage risks in normal course of business, executing risk plans/mitigation activities, and monitoring and reporting key risk information.

### Corporate Governance
Genmab works diligently to improve its guidelines and policies for corporate governance, taking into account the recent trends in international and domestic requirements and recommendations. Genmab's commitment to corporate governance is based on ethics and integrity and forms the basis of its effort to strengthen the confidence that existing and future shareholders, partners, employees and other stakeholders have in Genmab. The role of shareholders and their interaction with Genmab is important. Genmab believes that open and transparent communication is necessary to maintain the confidence of Genmab's shareholders and achieves this through company announcements, investor meetings and company presentations. Genmab is committed to providing reliable and transparent information about its business, financial results, development programs and scientific results in a clear and timely manner.

All Danish companies listed on the Nasdaq Copenhagen are required to disclose in their annual reports how they address the Recommendations for Corporate Governance issued by the Committee on Corporate Governance in December 2020 (the "Recommendations"), applying the "comply-or-explain" principle.

Genmab follows the Recommendations, except for one specific sub-area where Genmab's corporate governance principles differ from the Recommendations:

● The Recommendations provide that according to a company's takeover contingency procedures, the board of directors abstains from countering any takeover bids by taking actions that seek to prevent the shareholders from deciding on the takeover bid, without the approval of the general meeting. Genmab does not have such a restriction in its takeover contingency procedures and retains the right in certain circumstances to reject takeover bids without consulting the shareholders. Genmab believes this provides the Board of Directors with the needed flexibility to best respond to takeover bids and to negotiate with bidders; retaining this flexibility helps the Board of Directors meet its objectives in protecting and creating value in the interest of the shareholders. Actions will be determined on a case-by-case basis with due consideration to the interests of the shareholders and other stakeholders.

Genmab publishes its statutory report on Corporate Governance for the financial year 2022 cf. Article 107b of the Danish Financial Statements Act ("Lovpligtig redegørelse for virksomhedsledelse jf. årsregnskabslovens § 107 b") on the Company's website, including a detailed description of the Board of Directors' consideration in respect of all the Recommendations. The statutory report on Corporate Governance can be found on Genmab's website https://ir.genmab.com/corporate-governance.

#### THE BOARD OF DIRECTORS
The Board of Directors plays an active role within Genmab in setting the strategies and goals for Genmab and monitoring its operations and results. Board duties include establishing policies for strategy, accounting, organization and finance and the appointment of Executive Management members. The Board of Directors also assesses Genmab's capital and share structure and is responsible for approving share issues and the grant of warrants and RSUs.

The Board of Directors has established an annual process whereby the Board of Directors' performance is assessed through self-evaluation to verify that the Board of Directors is capable of fulfilling its function and responsibilities. When performing these evaluations external assistance is obtained every year. The outcome of the Board of Directors' 2022 self-assessment was positive with only minor areas for improvement identified.

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**GENMAB 2022 ANNUAL REPORT** 

#### BOARD COMMITTEES
To support the Board of Directors in its duties, the Board of Directors has established and appointed a Compensation Committee, an Audit and Finance Committee, a Nominating and Corporate Governance Committee and a Scientific Committee. These committees are charged with reviewing issues pertaining to their respective fields that are due to be considered at Board of Directors' meetings. Written charters specifying the tasks and responsibilities for each of the committees are available on Genmab's website www.genmab.com.

For more details on the work, composition and evaluation of the Board of Directors and its committees, reference is made to the statutory report on Corporate Governance.

#### Remuneration policy
A Remuneration Policy applying to the compensation of members of the Board of Directors and the registered Executive Management of Genmab A/S has been prepared in accordance with Sections 139 and 139a of the Danish Companies Act and was most recently considered and adopted by the 2021 Annual General Meeting pursuant to the Danish Companies Act (in Danish "Selskabsloven").

The Remuneration Policy contains an exhaustive description of the remuneration components for members of the Board of Directors and the registered Executive Management and includes the reasons for choosing the individual components of the remuneration and a description of the criteria on which the balance between the individual components of the remuneration is based. The latest version, which was adopted by the General Meeting in 2021, can be downloaded from Genmab's website https://ir.genmab.com/governance/compensation#content.

#### COMPENSATION REPORT
In accordance with the Recommendations, Genmab has prepared a compensation report for the financial year 2022 that includes information on the total remuneration received by each member of the Board of Directors and the registered Executive Management from Genmab A/S and other Group companies for the last three years, including information on the most important content of retention and resignation arrangements and the correlation between the remuneration and company strategy and relevant related goals (the "Compensation Report"). The Compensation Report can be found on Genmab's website https://ir.genmab.com/governance/compensation#content.

#### CHANGE OF CONTROL
The Danish Financial Statements Act (Section 107a) contains rules relating to listed companies with respect to certain disclosures that may be of interest to the stock market and potential takeover bidders, in particular in relation to disclosure of change of control provisions. In the event of a change of control, change of control clauses are included in some of our collaboration, development and license agreements as well as in service agreements for certain employees.

Collaboration, Development and License Agreements

Genmab has entered into collaboration, development and license agreements with external parties, which may be subject to renegotiation in the case of a change of control event as specified in the individual agreements. However, any changes in the agreements are not expected to have significant influence on our financial position.

Service Agreements with Executive Management and Employees

The service agreements with each registered member of the Executive Management may be terminated by Genmab with no less than 12 months' notice and by the registered member of the Executive Management with no less than six months' notice. In the event of a change of control of Genmab, the termination notice due to the registered member of the Executive Management is extended to 24 months. In the event of

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**GENMAB 2022 ANNUAL REPORT** 

termination by Genmab (unless for cause) or by a registered member of Executive Management as a result of a change of control of Genmab, Genmab is obliged to pay a registered member of Executive Management a compensation equal to his/her existing total salary (including benefits) for up to two years in addition to the notice period.

In addition, Genmab has entered into service agreements with a limited number of employees according to which Genmab may become obliged to compensate the employees in connection with a change of control of Genmab. If Genmab, as a result of a change of control, terminates the service agreement without cause or changes the working conditions to the detriment of the employee, the employee shall be entitled to terminate the employment relationship without further cause with one month's notice in which case Genmab shall pay the employee a compensation equal to one-half, one or two times the employee's existing annual salary (including benefits).

Change of control clauses related to our warrant and RSU programs are outlined in Note 4.6.

#### Share capital
Information on share capital is included in Note 4.7. Unless otherwise provided in the Danish Companies Act, the adoption of any resolution to amend Genmab A/S' articles of association shall be subject to the affirmative vote of not less than two thirds of the votes cast, as well as of the voting share capital represented at the general meeting. Genmab A/S' entire articles of association can be found on our website www.genmab.com.

**Board of Directors**

#### Deirdre P. Connelly
Hispanic/American, 62, Female

Board Chair (Independent, elected by the General Meeting); Chair of the Nominating and Corporate Governance Committee, Member of the Compensation Committee and the Audit and Finance Committee

First elected 2017, current term expires 2023

#### Special Competencies
More than 30 years' experience as a corporate leader and extensive experience in corporate governance as a board member. Comprehensive experience with business turnaround, corporate culture transformation, product launch and talent development. Successfully directed the launch of more than 20 new pharmaceutical drugs. Former President, North America Pharmaceuticals for GlaxoSmithKline.

#### Current Board Positions

#### Member: Lincoln Financial Corporation <sup>1</sup> , Macy's Inc. <sup>2</sup>
1. Chair of Corporate Governance Committee, Member of Audit Committee

2. Chair of Nominating and Governance Committee, Member of Compensation and Management Development Committee

#### Pernille Erenbjerg
Danish, 55, Female

Deputy Chair (Independent, elected by the General Meeting); Chair of the Audit and Finance Committee, Member of the Nominating and Corporate Governance Committee

First elected 2015, current term expires 2023

#### Special Competencies
Senior executive management and broad business experience from the telecoms, media and tech industries. Extensive experience with operation and strategic transformation of large and complex companies, including digital transformations and digitally based innovation. ESG experience from executive and non-executive positions. Comprehensive all-around background within finance, including extensive exposure to public and private equity and debt investors. Certified Public Accountant background (no longer practicing). Responsible

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for major transformation processes in complex organizations including M&A. Former CEO and President of TDC Group A/S. Due to her experience and background within accounting, Pernille Erenbjerg qualifies as an audit committee financial expert.

#### Current Board Positions

#### Chair: Nordic Entertainment Group (NENT)

#### Deputy Chair: Millicom <sup>1</sup>

#### Member: RTL Group <sup>2</sup> , GlobalConnect
1. Chair of Compensation Committee

2. Chair of Audit Committee

#### Anders Gersel Pedersen, M.D., Ph.D.
Danish, 71, Male

Board Member (Non-independent, elected by the General Meeting); Chair of the Compensation Committee, Member of the Nominating and Corporate Governance Committee and the Scientific Committee

First elected 2003, current term expires 2023

#### Special Competencies
Business and management experience in the pharmaceutical industry, including expertise in clinical research, development, regulatory affairs and product life cycle management. Former Executive Vice President of Research & Development of H. Lundbeck A/S.

#### Current Board Positions

#### Chair: Aelis Farma S.A.S.

#### Deputy Chair: Bavarian Nordic A/S <sup>1</sup>
Member: Hansa Biopharma AB<sup>2</sup>, Bond 2 Development 2 GP Limited

1. Member of Nomination and Compensation Committee, Member of Science, Technology & Investment Committee

2. Chair of Scientific Committee, Member of Remuneration Committee

#### Paolo Paoletti, M.D.
Italian (U.S. Citizen), 72, Male

Board Member (Independent, elected by the General Meeting); Chair of the Scientific Committee, Member of the Compensation Committee

First elected 2015, current term expires 2023

#### Special Competencies
Extensive experience in research, development and commercialization in the pharmaceutical industry. Successfully conducted submissions and approvals of new cancer drugs and new indications in the U.S. and in Europe. Responsible for seven new medicines for cancer patients during his 10 years at GlaxoSmithKline and one new cancer medicine during his time at Eli Lilly.

#### Current Position, Including Managerial Positions

#### Member of the Investment Committee for Apollo Therapeutics Limited
Scientific Advisor for 3B Future Health Fund

#### Current Board Positions
Member: Akamis Bio Limited

#### Rolf Hoffmann
German, 63, Male

Board Member (Independent, elected by the General Meeting); Member of the Audit and Finance Committee and the Scientific Committee

First elected 2017, current term expires 2023

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| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

#### Special Competencies
Extensive international management experience with expertise in creating and optimizing commercial opportunities in global markets. Additional expertise in P&L management, governance and Corporate Integrity Agreement Management, compliance and organizational efficiency. Over 20 years' experience in the international pharmaceutical and biotechnology industries at Eli Lilly and Amgen.

#### Current Position, Including Managerial Positions

#### Adjunct Professor Strategy and Entrepreneurship, University of North Carolina Business School

#### Current Board Positions

#### Member: Paratek Pharmaceuticals, Inc. <sup>1</sup> , IDT Biologika, Semdor Pharma
1. Member of Nominating and Corporate Governance Committee

#### Elizabeth A. O'Farrell
American, 58, Female

Board Member (Independent, elected by the General Meeting); Member of the Compensation Committee and the Audit & Finance Committee

First elected 2022, current term expires 2023

#### Special Competencies
Solid financial experience including strategic, operational and reporting across the value chain. Additional expertise in leading cross-functional teams, championing culture, and driving paradigm changing contributions within finance and the enterprise through collaboration and influence. Over 24 years' experience at Eli Lilly, in addition to experience at Price Waterhouse and Whipple & Company Corporation.

#### Current Board Positions
Chair: PDL BioPharma

Member: LENSAR<sup>1</sup>, Geron Corporation<sup>2</sup>, Karius<sup>3</sup>

1. Chair of Audit Committee

2. Chair of Audit Committee

3. Chair of Audit Committee

#### Takahiro Hamatani
Japanese, 48, Male

Board Member (Non-independent, elected by the employees)

First elected 2022, current term expires 2025

#### Special Competencies
Over 20 years' experience in the pharmaceutical industry in various roles including finance, sales/marketing, and corporate strategy. Extensive expertise in strategic business planning and finance business partnering. Experience in successful product launches, geographical expansions, and business development deals. Certified Public Accountant in the U.S.

#### Current Position, including Managerial Positions

#### Senior Director, Finance Japan at Genmab
**Martin Schultz**

Danish, 47, Male

Board Member (Non-independent, elected by the employees)

First elected 2022, current term expires 2025

#### Special Competencies
Broad experience within clinical trial management with a substantial understanding and knowledge of research and development. Specific expertise in project management, vendor collaboration, contract and budget management.

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| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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**GENMAB 2022 ANNUAL REPORT** 

#### Current Position, including Managerial Positions

#### Senior Director, Clinical Operations at Genmab

#### Mijke Zachariasse, Ph.D.
Dutch, 49, Female

Board Member (Non-independent, elected by the employees)

First elected 2019, current term expires 2025

#### Special Competencies
Broad experience in people and business management in the natural sciences sector. Specific expertise in building strategic partnerships across sectors, financial and fund management, and setting research strategies in the academic sector.

#### Current Position, including Managerial Positions

#### Senior Director, Head of Antibody Research Materials at Genmab

### Senior Leadership

#### Jan G. J. van de Winkel, Ph.D.
Dutch, 61, Male

President & Chief Executive Officer

#### Special Competencies
Extensive antibody creation and development expertise, broad knowledge of the biotechnology industry and executive management skills.

#### Current Board Positions
Chair: Hookipa Pharma

Member: Leo Pharma

#### Anthony Pagano
American, 45, Male

Executive Vice President & Chief Financial Officer

#### Special Competencies
Significant knowledge and experience in the life sciences industry particularly as it relates to corporate finance, corporate development, strategic planning, general management, treasury, accounting and corporate governance.

#### Judith Klimovsky, M.D.
Argentinian (U.S. Citizen), 66, Female

Executive Vice President & Chief Development Officer

#### Special Competencies
Extensive expertise in oncology drug development from early clinical stages through to marketing approval, experience in clinical practice and leading large teams in pharmaceutical organizations.

#### Current Board Positions
Member: Bellicum Pharmaceuticals

#### Anthony Mancini
Canadian-Italian (U.S. Citizen), 52, Male

Executive Vice President & Chief Operating Officer

#### Special Competencies
Significant expertise and experience in the life sciences industry across strategic and operational leadership roles; commercialization & launch, strategic planning, partnerships/alliances, general management, leading large Biopharma P&Ls and organizations.

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**GENMAB 2022 ANNUAL REPORT** 

#### Tahamtan Ahmadi, M.D., Ph.D.
Iranian-German (U.S. Citizen), 50, Male

Executive Vice President & Chief Medical Officer, Head of Experimental Medicines

#### Special Competencies

#### Significant expertise in global regulatory and clinical drug development across entire spectrum from pre-IND to life cycle management; drug discovery and translational research.

#### Birgitte Stephensen
Danish, 62, Female

Executive Vice President, Chief Legal Officer

#### Special Competencies
Intellectual property and legal expertise in the biotechnology field.

**Christopher Cozic**American, 45, Male Executive Vice President, Chief People Officer Special Competencies Expertise in strategic leadership, organization design, human resource management, policy development, employee relations, organizational development, and a heavy concentration in all aspects of corporate growth and expansion.** 

#### Martine J. van Vugt, Ph.D.
Dutch, 52, Female

Senior Vice President, Corporate Strategy and Planning

#### Special Competencies

#### Extensive knowledge of and experience in Corporate Strategy, Business Development, as well as Portfolio, Project and Alliance Management .

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**GENMAB 2022 ANNUAL REPORT** 

### Shareholders and Share Information

#### OWNERSHIP
Genmab is dual listed on the Nasdaq Copenhagen and the Nasdaq Global Select Market in the U.S. under the symbol GMAB. Our communication with the capital markets complies with the disclosure rules and regulations of these exchanges. As of December 31, 2022, the number of registered shareholders totaled 78,928 shareholders holding a total of 64,166,414 shares, which represented 97% of the total share capital of 65,961,573. The following table shows share data as of December 31, 2022.

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| **Share Data**<br>| <br>**Denmark** | <br>**U.S.** |  |
| Number of shares at December 31, 2022 | 65961573 | 4661201 | (represented by 46,612,010 American Depository Shares (ADSs)) |
| Listing | Nasdaq Copenhagen | Nasdaq Global Select Market, New York | Nasdaq Global Select Market, New York |
| Ticker Symbol | GMAB | GMAB |  |
| Index Membership | OMX Nordic Large Cap Index<br>OMX Copenhagen Benchmark Index<br>OMX Copenhagen 25 Index (OMXC25) | Nasdaq Biotech Index |  |

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The following shareholders are registered in Genmab's register of shareholders as being the owner of a minimum of 5% of the voting rights or a minimum of 5% of the share capital (one share equals one vote) as of December 31, 2022:

● BlackRock, Inc., 55 East 52 <sup>nd</sup> Street, New York, New York 10055, United States of America (6.8%)

● Wellington Management Group LLP, 280 Congress Street, Boston, Massachusetts, United States of America (6.18%)

Shareholders registered in the Company's shareholder registry may sign up for electronic shareholder communications via Genmab's investor portal. The investor portal can be accessed at Genmab's website www.genmab.com/investors. Electronic shareholder communication enables Genmab to, among other things, quickly and efficiently call general meetings.

The charts included here illustrate the performance of the Genmab share during 2022 and the geographical distribution of our shareholders. As of December 31, 2022 Genmab's shares closed at DKK 2,941 and ADSs

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**GENMAB 2022 ANNUAL REPORT** 

closed at USD 42.38. Please refer to Note 4.7 of the financial statements for additional information regarding Genmab's share capital including authorizations to issue shares and purchase its own shares.

![Graphic](gmab-20221231xex99d1019.jpg)

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**GENMAB 2022 ANNUAL REPORT** 

Genmab is a Foreign Private Issuer as defined in the SEC's rules and regulations. The determination of foreign private issuer status is made annually on June 30. We will next make a determination with respect to our foreign private issuer status on June 30, 2023.

#### AMERICAN DEPOSITARY RECEIPT (ADR) PROGRAM
Genmab has a sponsored Level 3 ADR program with Deutsche Bank Trust Company Americas. An ADS is a share certificate representing ownership of shares in a non-U.S. corporation. ADSs issued under Genmab's ADR Program are quoted and traded in U.S. dollars on the Nasdaq Global Select Market in the United States. Ten Genmab ADSs correspond to one Genmab ordinary share. Genmab's ADR ticker symbol is GMAB. For more information on Genmab's ADR Program, visit https://ir.genmab.com/adr-program#content.

#### INVESTOR RELATIONS
Genmab's Investor Relations department aims to ensure relevant, accurate and timely information is available to our investors and the financial community. We maintain an ongoing dialogue with sell-side equity analysts, as well as major institutional and retail shareholders. A list of the current analysts covering Genmab can be found at our website along with financial reports, company announcements, current presentations, fact sheets and other downloads.

**Contact:For Media Relations:**

Marisol Peron, Senior Vice President, Global Communications & Corporate Affairs

T: +1 609 524 0065; E: mmp@genmab.com

#### For Investor Relations:
Andrew Carlsen, Vice President, Head of Investor Relations

T: +45 33 77 95 58; E: acn@genmab.com

#### Annual General Meeting
Genmab's Annual General Meeting will be held on March 29, 2023 at 2:00 PM CEST. Further details will be included in the notice to convene the Annual General Meeting.

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|:---|:---|
| &nbsp;&nbsp;**Financial Calendar for 2023** | &nbsp;&nbsp;**Financial Calendar for 2023** |
| &nbsp;&nbsp;Annual General Meeting 2023 | &nbsp;&nbsp;Wednesday, March 29, 2023 |
| &nbsp;&nbsp;Publication of the Interim Report for the first quarter 2023 | &nbsp;&nbsp;Wednesday, May 10, 2023 |
| &nbsp;&nbsp;Publication of the Interim Report for the first half 2023 | &nbsp;&nbsp;Thursday, August 3, 2023 |
| &nbsp;&nbsp;Publication of the Interim Report for the first nine months 2023 | &nbsp;&nbsp;Tuesday, November 7, 2023 |

---

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 73/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

### Financial Statements for the Genmab Group

#### Introduction
The financial statements in the 2022 Annual Report are grouped into the following sections: Primary Statements; Basis of Presentation; Results for the Year; Operating Assets and Liabilities; Capital Structure, Financial Risk and Related Items; and Other Disclosures.

Each note to the financial statements includes information about the accounting policies applied and significant management judgements and estimates in addition to the financial numbers.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 74/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### **Table of Contents**

---

| | |
|:---|:---|
| [**PRIMARY STATEMENTS**](#_Primary_Statements) | 76 |
| &nbsp;&nbsp;&nbsp;&nbsp;[Consolidated Statements of Comprehensive Income](#_Consolidated_Statements_of) | 76 |
| &nbsp;&nbsp;&nbsp;&nbsp;[Consolidated Balance Sheets](#ConsolidatedBalanceSheets_755838) | 77 |
| &nbsp;&nbsp;&nbsp;&nbsp;[Consolidated Statements of Cash Flows](#StatementsofCashFlows_164745) | 78 |
| &nbsp;&nbsp;&nbsp;&nbsp;[Consolidated Statements of Changes in Equity](#StatementsofChangesinEquity) | 79 |
| [**SECTION 1 – BASIS OF PRESENTATION**](#Section1BasisofPresentation_511358) | 80 |
| &nbsp;&nbsp;&nbsp;&nbsp;[1.1 Nature of the Business and Accounting Policies](#a11NatureoftheBusinessandAccounting_4340) | 80 |
| &nbsp;&nbsp;&nbsp;&nbsp;[1.2 New Accounting Policies and Disclosures](#a12NewAccountingPoliciesand_473176) | 83 |
| &nbsp;&nbsp;&nbsp;&nbsp;[1.3 Management's Judgements and Estimates under IFRS](#a13ManagementsJudgmentsandEstimates_2092) | 84 |
| [**SECTION 2 – RESULTS FOR THE YEAR**](#Section2ResultsfortheYear_668157) | 86 |
| &nbsp;&nbsp;&nbsp;&nbsp;[2.1 Revenue](#a21Revenue_55598) | 86 |
| &nbsp;&nbsp;&nbsp;&nbsp;[2.2 Information about Geographical Areas](#a22InformationaboutGeographical_54346) | 88 |
| &nbsp;&nbsp;&nbsp;&nbsp;[2.3 Staff Costs](#a23StaffCosts_45482) | 89 |
| &nbsp;&nbsp;&nbsp;&nbsp;[2.4 Corporate and Deferred Tax](#a24CorporateandDeferredTax_74273) | 89 |
| &nbsp;&nbsp;&nbsp;&nbsp;[2.5 Profit Per Share](#a25ResultPerShare_837617) | 92 |
| [**SECTION 3 – OPERATING ASSETS AND LIABILITIES**](#Section3OperatingAssetsand_582435) | 93 |
| &nbsp;&nbsp;&nbsp;&nbsp;[3.1 Intangible Assets](#a31IntangibleAssets_707645) | 93 |
| &nbsp;&nbsp;&nbsp;&nbsp;[3.2 Property and Equipment](#a32PROPERTYPLANTANDEQUIPMENT_442321) | 95 |
| &nbsp;&nbsp;&nbsp;&nbsp;[3.3 Leases](#a33Leases_635966) | 96 |
| &nbsp;&nbsp;&nbsp;&nbsp;[3.4 Other Investments](#a34OtherInvestments_986733) | 98 |
| &nbsp;&nbsp;&nbsp;&nbsp;[3.5 Receivables](#a35Receivables_567550) | 99 |
| &nbsp;&nbsp;&nbsp;&nbsp;[3.6 Deferred Revenue](#a37DeferredRevenue) | 99 |
| &nbsp;&nbsp;&nbsp;&nbsp;[3.7 Other Payables](#a37OtherPayables_696512) | 101 |
| [**SECTION 4 – CAPITAL STRUCTURE, FINANCIAL RISK AND RELATED ITEMS**](#Section4CapitalStructureFinancial_915403) | 101 |
| &nbsp;&nbsp;&nbsp;&nbsp;[4.1 Capital Management](#a41CapitalManagement_645386) | 101 |
| &nbsp;&nbsp;&nbsp;&nbsp;[4.2 Financial Risk](#a42FinancialRisk_69910) | 102 |
| &nbsp;&nbsp;&nbsp;&nbsp;[4.3 Financial Assets and Liabilities](#a43FinancialAssetsandLiabilities_786769) | 106 |
| &nbsp;&nbsp;&nbsp;&nbsp;[4.4 Marketable Securities](#a44MarketableSecurities_172782) | 109 |
| &nbsp;&nbsp;&nbsp;&nbsp;[4.5 Financial Income and Expenses](#a45FinancialIncomeandExpenses_830540) | 110 |
| &nbsp;&nbsp;&nbsp;&nbsp;[4.6 Share-Based Instruments](#a46ShareBasedInstruments_171094) | 111 |
| &nbsp;&nbsp;&nbsp;&nbsp;[4.7 Share Capital](#a47ShareCapital_319017) | 119 |
| [**SECTION 5 – OTHER DISCLOSURES**](#Section5OtherDisclosures_187855) | 121 |
| &nbsp;&nbsp;&nbsp;&nbsp;[5.1 Remuneration of the Board of Directors and Executive Management](#a51RemunerationoftheBoardofDirectors_233) | 121 |
| &nbsp;&nbsp;&nbsp;&nbsp;[5.2 Related Party Disclosures](#a52RelatedPartyDisclosures_200368) | 123 |
| &nbsp;&nbsp;&nbsp;&nbsp;[5.3 Commitments](#a54Commitments_535421) | 123 |
| &nbsp;&nbsp;&nbsp;&nbsp;[5.4 Fees to Auditors Appointed at the Annual General Meeting](#a56FeestoAuditorsAppointedatthe_6851) | 124 |
| &nbsp;&nbsp;&nbsp;&nbsp;[5.5 Adjustments to Cash Flow Statements](#a57AdjustmentstoCashFlowStatement_441737) | 124 |
| &nbsp;&nbsp;&nbsp;&nbsp;[5.6 Collaborations and Technology Licenses](#a58CollaborationsandTechnology_329265) | 125 |
| &nbsp;&nbsp;&nbsp;&nbsp;[5.7 Subsequent Events](#a59Subsequentevents) | 129 |

---

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|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 75/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

### Primary Statements

#### Consolidated Statements of Comprehensive Income

#### INCOME STATEMENT

---

| | | | | |
|:---|:---|:---|:---|:---|
| (DKK million) | Note | 2022 | 2021 | 2020 |
| **Revenue** | 2.1, 2.2 | **14595** | **8482** | **10111** |
| Research and development expenses | 2.3, 3.1, 3.2 | (5562) | (4181) | (3137) |
| Selling, general and administrative expenses | 2.3, 3.2 | (2676) | (1283) | (661) |
| **Operating expenses** |  | **(8238)** | **(5464)** | **(3798)** |
| **Operating profit** |  | **6357** | **3018** | **6313** |
| Financial income | 4.5 | 1358 | 1667  | 1149  |
| Financial expenses | 4.5 | (680) | (702) | (1558) |
| **Net profit before tax** |  | **7035** | **3983** | **5904** |
| Corporate tax | 2.4 | (1513) | (975) | (1146) |
| **Net profit** |  | **5522** | **3008** | **4758** |
| Basic net profit per share | 2.5 | 84.45 | 46.00 | 73.00 |
| Diluted net profit per share | 2.5 | 83.65 | 45.54 | 72.21 |
| **Statement of Comprehensive Income** |  |  |  |  |
| **Net profit** |  | **5522** | **3008** | **4758** |
| **Other comprehensive income:** |  |  |  |  |
| ***Amounts which may be re-classified to the income statement:*** |  |  |  |  |
| Exchange differences on translation of foreign operations |  | 17 | 27 | (44) |
| **Total comprehensive income** |  | **5539** | **3035** | **4714** |

---

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 76/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### Consolidated Balance Sheets

---

| | | | |
|:---|:---|:---|:---|
|  |  | December 31, | December 31, |
| (DKK million) | Note | 2022 | 2021 |
| **ASSETS** |  |  |  |
| Intangible assets | 2.2, 3.1 | 146 | 254 |
| Property and equipment | 2.2, 3.2 | 799 | 621 |
| Right-of-use assets | 2.2, 3.3 | 523 | 354 |
| Receivables | 2.2, 3.5 | 48 | 27 |
| Deferred tax assets | 2.4 | 252 | 264 |
| Other investments | 3.4 | 133 | 371 |
| **Total non-current assets** |  | **1901** | **1891** |
| Corporate tax receivable | 2.4 | 143 | 31 |
| Receivables | 3.5 | 5910 | 3367 |
| Marketable securities | 4.2, 4.4 | 12431 | 10381 |
| Cash and cash equivalents |  | 9893 | 8957 |
| **Total current assets** |  | **28377** | **22736** |
| **Total assets** |  | **30278** | **24627** |
| **SHAREHOLDERS' EQUITY AND LIABILITIES** |  |  |  |
| Share capital | 4.7 | 66 | 66 |
| Share premium | 4.7 | 12309 | 12029 |
| Other reserves |  | 98 | 81 |
| Retained earnings |  | 14968 | 10020 |
| **Total shareholders' equity** |  | **27441** | **22196** |
| Lease liabilities | 3.3 | 523 | 363 |
| Deferred revenue | 3.6 | 480 | 487 |
| Other payables | 3.7 | 11 | 13 |
| **Total non-current liabilities** |  | **1014** | **863** |
| Lease liabilities | 3.3 | 74 | 62 |
| Deferred revenue | 3.6 | 33 | 26 |
| Other payables | 3.7 | 1716 | 1480 |
| **Total current liabilities** |  | **1823** | **1568** |
| **Total liabilities** |  | **2837** | **2431** |
| **Total shareholders' equity and liabilities** |  | **30278** | **24627** |

---

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| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 77/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### Consolidated Statements of Cash Flows

---

| | | | | |
|:---|:---|:---|:---|:---|
| (DKK million) | Note | 2022 | 2021 | 2020 |
| **Cash flows from operating activities:** |  |  |  |  |
| **Net profit before tax** |  | **7035** | **3983** | **5904** |
| Reversal of financial items, net | 4.5 | (678) | (965) | 409 |
| Adjustment for non-cash transactions | 5.5 | 801 | 526 | 459  |
| Change in operating assets and liabilities | 5.5 | (1930) | (770) | 987  |
| **Cash flows from operating activities before financial items** |  | **5228** | **2774** | **7759** |
| Interest received |  | 283 | 208 | 170  |
| Interest elements of lease payments | 3.3 | (15) | (12) | (9) |
| Interest paid  |  | (1) | - | (11) |
| Corporate taxes paid |  | (1583) | (742) | (1476) |
| **Net cash provided by operating activities** |  | **3912** | **2228** | **6433** |
| **Cash flows from investing activities:** |  |  |  |  |
| Investment in tangible assets | 3.2 | (317) | (252) | (307) |
| Marketable securities bought |  | (9659) | (15514) | (12414) |
| Marketable securities sold |  | 7254 | 14469 | 10370  |
| Other investments bought | 3.4 | (39) | (102) | - |
| Other investments sold | 3.4 | - | 438 | - |
| **Net cash (used in) investing activities** |  | **(2761)** | **(961)** | **(2351)** |
| **Cash flows from financing activities:** |  |  |  |  |
| Warrants exercised |  | 280 | 135 | 140  |
| Principal elements of lease payments | 3.3 | (73) | (58) | (44) |
| Purchase of treasury shares |  | (908) | (447) | - |
| Payment of withholding taxes on behalf of employees on net settled RSUs |  | (88) | (50) | (25) |
| **Net cash provided by (used in) financing activities** |  | **(789)** | **(420)** | **71** |
| **Changes in cash and cash equivalents** |  | **362** | **847** | **4153** |
| Cash and cash equivalents at the beginning of the period |  | 8957 | 7260 | 3552 |
| Exchange rate adjustments |  | 574 | 850 | (445) |
| **Cash and cash equivalents at the end of the period** |  | **9893** | **8957** | **7260** |
| **Cash and cash equivalents include:** |  |  |  |  |
| Bank deposits |  | 9299 | 8661 | 5054 |
| Short-term marketable securities |  | 594 | 296 | 2206 |
| **Cash and cash equivalents at the end of the period** |  | **9893** | **8957** | **7260** |

---

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| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 78/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### Consolidated Statements of Changes in Equity

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| (DKK million) | Share capital | Share premium | Translation reserves | Retained earnings | Shareholders' equity |
| **Balance at December 31, 2019** | **65** | **11755** | **98** | **2130** | **14048** |
| Net profit | - | - | - | 4758 | 4758 |
| Other comprehensive income | - | - | (44) | - | (44) |
| **Total comprehensive income** | **-** | **-** | **(44)** | **4758** | **4714** |
| **Transactions with owners:** |  |  |  |  |  |
| Exercise of warrants | 1 | 139 | - | - | 140 |
| Share-based compensation expenses | - | - | - | 200 | 200 |
| Net settlement of RSUs | - | - | - | (25) | (25) |
| Tax on items recognized directly in equity | - | - | - | 44 | 44 |
| **Balance at December 31, 2020** | **66** | **11894** | **54** | **7107** | **19121** |
| Net profit | - | - | - | 3008 | 3008 |
| Other comprehensive income | - | - | 27 | - | 27 |
| **Total comprehensive income** | **-** | **-** | **27** | **3008** | **3035** |
| **Transactions with owners:** |  |  |  |  |  |
| Exercise of warrants | - | 135 | - | - | 135 |
| Purchase of treasury shares | - | - | - | (447) | (447) |
| Share-based compensation expenses | - | - | - | 310 | 310 |
| Net settlement of RSUs | - | - | - | (50) | (50) |
| Tax on items recognized directly in equity | - | - | - | 92 | 92 |
| **Balance at December 31, 2021** | **66** | **12029** | **81** | **10020** | **22196** |
| Net profit | - | - | - | 5522 | 5522 |
| Other comprehensive income | - | - | 17 | - | 17 |
| **Total comprehensive income** | **-** | **-** | **17** | **5522** | **5539** |
| **Transactions with owners:** |  |  |  |  |  |
| Exercise of warrants | - | 280 | - | - | 280 |
| Purchase of treasury shares | - | - | - | (908) | (908) |
| Share-based compensation expenses | - | - | - | 439 | 439 |
| Net settlement of RSUs | - | - | - | (88) | (88) |
| Tax on items recognized directly in equity | - | - | - | (17) | (17) |
| **Balance at December 31, 2022** | **66** | **12309** | **98** | **14968** | **27441** |

---

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 79/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

### Section 1 – Basis of Presentation
These consolidated financial statements include Genmab A/S (parent company) and subsidiaries over which the parent company has control. The Genmab consolidated Group is referenced herein as "Genmab" or the "Company".

This section describes Genmab's financial accounting policies including management's judgements and estimates under International Financial Reporting Standards (IFRS). New or revised EU endorsed accounting standards and interpretations are described, in addition to how these changes are expected to impact the financial performance and reporting of Genmab.

Genmab describes the accounting policies in conjunction with each note with the aim to provide a more understandable description of each accounting area.

**ESEF Reporting** Genmab is required to file the Annual Report in the European Single Electronic Format (ESEF) using the XHTML format and to tag the consolidated financial statements including notes using Inline eXtensible Business Reporting Language (iXBRL). The iXBRL tags comply with the ESEF taxonomy. Where a financial statement line item is not defined in the ESEF taxonomy, an extension to the taxonomy has been created. The annual report submitted to the Danish Financial Supervisory Authority consists of the XHTML document together with certain technical files, all included in a file named 529900MTJPDPE4MHJ122-2022-12-31-en.zip.

1.1 – Nature of the Business and Accounting Policies

Genmab A/S is a publicly traded, international biotechnology company that was founded in 1999 and specializes in the creation and development of differentiated antibody therapeutics for the treatment of cancer and other diseases. Genmab has five approved products commercialized by third parties, one approved product that is jointly commercialized with a collaboration partner, a broad clinical and pre-clinical product pipeline and proprietary next-generation antibody technologies.

The consolidated financial statements have been prepared in accordance with IFRS as issued by the International Accounting Standards Board (IASB) and in accordance with IFRS as endorsed by the EU and further requirements in the Danish Financial Statements Act. The consolidated financial statements were approved by the Board of Directors and authorized for issue on February 22, 2023. Except as outlined in **Note 1.2**, the financial statements have been prepared using the same accounting policies as 2021.

Please refer to the overview below to see in which note/section the detailed accounting policy is included.

---

| | |
|:---|:---|
| **Section 2 – Results for the Year**  | 3.3 Leases  |
| 2.1 Revenue | 3.4 Other Investments |
| 2.2 Information about Geographical Areas | 3.5 Receivables |
| 2.3 Staff Costs | 3.7 Other Payables |
| 2.4 Corporate and Deferred Tax | **Section 4 – Capital Structure, Financial Risk and Related Items** |
| 2.5 Profit per Share  | 4.3 Financial Assets and Liabilities |
| **Section 3 – Operating Assets and Liabilities**  | 4.4 Marketable Securities |
| 3.1 Intangible Assets | 4.5 Financial Income and Expenses |
| 3.2 Property and Equipment | 4.6 Share-Based Instruments |

---

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| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 80/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### Materiality
Genmab's Annual Report is based on the concept of materiality and the Company focuses on information that is considered material and relevant to the users of the consolidated financial statements. The consolidated financial statements consist of a large number of transactions. These transactions are aggregated into classes according to their nature or function and presented in classes of similar items in the consolidated financial statements as required by IFRS and the Danish Financial Statements Act. If items are individually immaterial, they are aggregated with other items of similar nature in the financial statements or in the notes.

The disclosure requirements are substantial in IFRS and for Danish listed companies. Genmab provides these specific required disclosures unless the information is considered immaterial to the economic decision-making of the readers of the financial statements or not applicable.

#### Consolidated Financial Statements
The consolidated financial statements include Genmab A/S and subsidiaries over which the parent company has control. The parent controls a subsidiary when the parent is exposed to, or has rights to, variable returns from its involvement with the subsidiary and has the ability to affect those returns through its power to direct the activities of the subsidiary. Genmab A/S (parent company) holds investments either directly or indirectly in the following subsidiaries:

---

| | | | |
|:---|:---|:---|:---|
|  |  | 2<br>| 1<br>|
| &nbsp;&nbsp;Name | &nbsp;&nbsp;Domicile | Ownership and votes<br>2022 | Ownership and votes<br>2021 |
| &nbsp;&nbsp;Genmab B.V. | &nbsp;&nbsp;Utrecht, the Netherlands | 100% | 100% |
| &nbsp;&nbsp;Genmab Holding B.V. | &nbsp;&nbsp;Utrecht, the Netherlands | 100% | 100% |
| &nbsp;&nbsp;Genmab US, Inc. | &nbsp;&nbsp;New Jersey, USA  | 100% | 100% |
| &nbsp;&nbsp;Genmab K.K. | &nbsp;&nbsp;Tokyo, Japan | 100% | 100% |

---

Genmab's consolidated financial statements have been prepared on the basis of the financial statements of the parent company and subsidiaries – prepared under Genmab's accounting policies – by combining similar accounting items on a line-by-line basis. On consolidation, intercompany income and expenses, intercompany receivables and payables, and unrealized gains and losses on transactions between the consolidated companies are eliminated.

The recorded value of the equity interests in the consolidated subsidiaries is eliminated with the proportionate share of the subsidiaries' equity. Subsidiaries are consolidated from the date when control is transferred to the Group.

The income statements for subsidiaries with a different functional currency than Genmab's presentation currency are translated into Genmab's presentation currency at average exchange rates, and the balance sheets are translated at the exchange rate in effect at the balance sheet date.

Exchange rate differences arising from the translation of foreign subsidiaries shareholders' equity at the beginning of the year and exchange rate differences arising as a result of foreign subsidiaries' income statements being translated at average exchange rates are recorded in translation reserves in shareholders' equity.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 81/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### Functional and Presentation Currency
The financial statements have been prepared in Danish Kroner (DKK), which is the functional and presentation currency of the parent company.

#### Foreign Currency
Transactions in foreign currencies are translated at the exchange rates in effect at the date of the transaction.

Exchange rate gains and losses arising between the transaction date and the settlement date are recognized in the income statement as financial income or expense.

Unsettled monetary assets and liabilities in foreign currencies are translated at the exchange rates in effect at the balance sheet date. Exchange rate gains and losses arising between the transaction date and the balance sheet date are recognized in the income statement as financial income or expense.

#### Classification of Operating Expenses in the Income Statement
*Research and Development Expenses*

Research and development expenses primarily include salaries, benefits and other employee-related costs of Genmab's research and development staff, license costs, manufacturing costs, pre-clinical costs, clinical trials, contractors and outside service fees, amortization and impairment of licenses and rights related to intangible assets, depreciation of property and equipment, and depreciation of right-of-use assets, to the extent that such costs are related to the Group's research and development activities.

Refer to Note 3.1 for a more detailed description on the treatment of Genmab's research and development expenses.

*Selling, General and Administrative Expenses*

Selling, general and administrative expenses relate to the management and administration of Genmab, including commercialization activities. This primarily includes salaries, benefits and other employee costs related to management and support functions including human resources, information technology and the finance departments. In addition, depreciation of property and equipment and depreciation of right-of-use assets, to the extent such expenses are related to administrative functions, are also included. Selling, general and administrative expenses are recognized in the income statement in the period to which they relate.

#### Statements of Cash Flows
The cash flow statement is presented using the indirect method with basis in the net profit before tax.

Cash flows from operating activities are stated as the net profit before tax adjusted for net financial items, non-cash operating items such as depreciation, amortization, impairment losses, share-based compensation expenses, provisions, and for changes in operating assets and liabilities, interest paid and received, interest elements of lease payments and corporate taxes paid or received. Operating assets and liabilities are mainly comprised of changes in receivables and other payables excluding the items included in cash and cash equivalents. Changes in non-current assets and liabilities are included in operating assets and liabilities, if related to the main revenue-producing activities of Genmab.

Cash flows from investing activities consist of purchases and sales of marketable securities and other investments, as well as purchases of property and equipment.

Cash flows from financing activities relate to the purchase of treasury shares, exercise of warrants, payments of withholding taxes on behalf of employees on net settled RSUs and payments of long-term loans including installments on lease liabilities.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 82/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

Cash and cash equivalents are comprised of cash, bank deposits, and marketable securities with a maturity of less than ninety days on the date of acquisition.

The statements of cash flows cannot be derived solely from the financial statements.

#### Treasury Shares
The total amount paid to acquire treasury shares including directly attributable costs and the proceeds from the sale of treasury shares is recognized in retained earnings.

#### Research Collaborations, License Agreements and Collaborative Agreements

#### Research Collaborations and License Agreements
Genmab continues to pursue the establishment of research collaborations and licensing agreements. These arrangements often include upfront payments, expense reimbursements or payments to the collaboration partner, and milestone and royalty arrangements, contingent upon the occurrence of certain future events linked to the success of the asset in development.

In regard to Genmab's license agreements with Janssen, Novartis and Roche, each of these parties retain final decision-making authority over the relevant activities and as such no joint control exists.

Refer to Note 2.1 for additional information related to revenue from these parties.

*Joint Collaborative Agreements* 

Genmab has entered into a number of joint collaborative agreements. These agreements often include upfront payments, expense reimbursements or payments to the collaboration partner, and milestone and royalty arrangements, contingent upon the occurrence of certain future events linked to the success of the asset in development.

These agreements also provide Genmab with varying rights to develop, produce and market products together with its collaborative partners. Both parties in these arrangements share in the decision making and therefore have joint control of the arrangement. In 2022, Genmab's more significant collaboration agreements are with AbbVie (Epcoritamab), Seagen (Tisotumab vedotin) and BioNTech.

Refer to Note 2.1 for additional information related to revenue from our joint collaborative agreements.

Refer to Note 5.6 for detailed information regarding Genmab's significant Research Collaborations, License Agreements and Collaborative Agreements.

1.2 New Accounting Policies and Disclosures

#### NEW ACCOUNTING POLICIES AND DISCLOSURES FOR 2022
Genmab has, with effect from January 1, 2022, implemented the following standards and amendments:

● Amendments to IFRS 3 Business Combinations;

● Amendments to IAS 16 Property, Plant and Equipment;

● Amendments to IAS 37 Provisions, Contingent Liabilities and Contingent Assets; and

● Annual Improvements 2018-2020

All of the above amendments were issued on May 14, 2020. The implementation of these amendments did not have a material impact on the consolidated financial statements for the current or prior reporting periods and is not expected to have a significant impact in future reporting periods.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 83/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### NEW ACCOUNTING POLICIES AND DISCLOSURES EFFECTIVE IN 2023 OR LATER
The IASB has issued a number of new standards and updated some existing standards, the majority of which are effective for accounting periods beginning on January 1, 2023 or later. Therefore, they are not incorporated in these consolidated financial statements. There are no standards presently known that are not yet effective and that would be expected to have a material impact on Genmab in current or future reporting periods and on foreseeable future transactions.

1.3 Management's Judgements and Estimates under IFRS

In preparing financial statements under IFRS, certain provisions in the standards require management's judgements, including various accounting estimates and assumptions. These judgements and estimates affect the application of accounting policies, as well as reported amounts within the consolidated financial statements and disclosures.

Determining the carrying amount of certain assets and liabilities requires judgements, estimates and assumptions concerning future events that are based on historical experience and other factors, which by their very nature are associated with uncertainty and unpredictability.

Accounting estimates are based on historical experience and various other factors relative to the circumstances in which they are applied. Estimates are generally made based on information available at the time.

Accounting judgements are made in the process of applying accounting policies. These judgements are typically made based on the guidance and information available at the time of application.

These estimates and judgements may prove incomplete or incorrect, and unexpected events or circumstances may arise. Genmab is also subject to risks and uncertainties which may lead actual results to differ from these estimates, both positively and negatively. Specific risks for Genmab are discussed in the relevant section of this Annual Report and in the notes to the consolidated financial statements.

The areas involving a high degree of judgement and estimation that are significant to the consolidated financial statements are summarized below. Refer to the identified notes for further information on the key accounting estimates and judgements utilized in the preparation of the consolidated financial statements.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 84/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

---

| | | | |
|:---|:---|:---|:---|
| &nbsp;&nbsp;**Accounting Policy** | &nbsp;&nbsp;**Key Accounting Estimates and Judgements** | &nbsp;&nbsp;**Note Reference** | &nbsp;&nbsp;**Estimation Risk** |
| &nbsp;&nbsp;Revenue Recognition | &nbsp;&nbsp;Estimation of partner net sales amounts in the calculation of royalties<br>Judgement in assessing the probability of attainment of milestones<br>Estimation of variable consideration<br>Judgement in assessing the nature of combined performance obligations within contracts <br>| &nbsp;&nbsp;Note 2.1 | &nbsp;&nbsp;Moderate / High |
| &nbsp;&nbsp;Share Based Compensation | &nbsp;&nbsp;Judgement in selecting assumptions required for valuation of warrant grants | &nbsp;&nbsp;Note 4.6 | &nbsp;&nbsp;Moderate |
| &nbsp;&nbsp;Current and deferred income taxes | &nbsp;&nbsp;Judgement and estimation regarding valuation of deferred income tax assets<br>Estimation in developing the provision for any uncertain tax positions | &nbsp;&nbsp;Note 2.4 | &nbsp;&nbsp;Moderate |
| &nbsp;&nbsp;Intangible assets | &nbsp;&nbsp;Judgement in determining impairment of an intangible asset | &nbsp;&nbsp;Note 3.1 | &nbsp;&nbsp;Low |

---

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 85/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

### Section 2 Results for the Year
This section includes disclosures related to revenue, information about geographical areas, staff costs, corporate and deferred tax and profit per share. A detailed description of the results for the year is provided in the Financial Review section in the Management's Review.

2.1 - Revenue

---

| | | | |
|:---|:---|:---|:---|
| (DKK million) | 2022 | 2021 | 2020 |
| **Revenue by type:** |  |  |  |
| Royalties  | 11672 | 6977 | 4741 |
| Reimbursement revenue | 818 | 531 | 431 |
| Milestone revenue | 1767 | 954 | 351 |
| License revenue | 6 | - | 4588 |
| Collaboration revenue | 332 | 20 | - |
| **Total**  | **14595** | **8482** | **10111** |
| **Revenue by collaboration partner:** |  |  |  |
| Janssen | 10620 | 6847 | 4693 |
| AbbVie | 1174 | 245 | 4398 |
| Roche | 796 | 603 | 305 |
| Novartis | 815 | 236 | 212 |
| BioNTech | 708 | 416 | 230 |
| Seagen | 413 | 135 | 201 |
| Other  | 69 | - | 72 |
| **Total**  | **14595** | **8482** | **10111** |
| **Royalties by product:** |  |  |  |
| DARZALEX | 10056 | 6135 | 4419 |
| TEPEZZA | 796 | 593 | 298 |
| Kesimpta | 779 | 235 | 10 |
| Other | 41 | 14 | 14 |
| **Total** | **11672** | **6977** | **4741** |

---

#### ACCOUNTING POLICIES
Genmab recognizes revenue when its customer obtains control of promised goods or services, in an amount that reflects the consideration that it expects to receive in exchange for those goods or services. To determine revenue recognition for arrangements that Genmab determines are within the scope of IFRS 15, Genmab performs the following five steps: (i) identify the contract(s) with a customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when (or as) the entity satisfies a performance obligation. Genmab only applies the five-step model to contracts when it is probable that the

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 86/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

Company will collect the consideration it is entitled to in exchange for the goods or services it transfers to the customer. At contract inception, once the contract is determined to be within the scope of IFRS 15, Genmab assesses the goods and services promised within each contract and identifies as a performance obligation each good or service that is distinct. Revenue is recognized in the amount of the transaction price that is allocated to the respective performance obligation when (or as) the performance obligation is satisfied.

**Royalties:** Certain of Genmab's license and collaboration agreements include sales-based royalties based on the level of sales. The license has been deemed to be the predominant item to which the royalties relate under Genmab's license and collaboration agreements. As a result, Genmab recognizes revenue when the related sales occur.

**Reimbursement Revenue for R&D Services:** Genmab's research collaboration agreements include the provisions for reimbursement or cost sharing for research and development services and payment for FTEs at contractual rates. R&D services are performed and satisfied over time given that the customer simultaneously receives and consumes the benefits provided by Genmab and revenue for research services is recognized over time rather than at a point in time.

**Milestone Revenue:** Certain of Genmab's license and collaboration agreements include development, regulatory and commercial milestone payments based on the level of sales. At the inception of each arrangement that includes milestone payments, Genmab evaluates whether the achievement of milestones is considered highly probable and estimates the amount to be included in the transaction price using the most likely amount method. If it is highly probable that a significant revenue reversal would not occur, the associated milestone value is included in the transaction price. Milestone payments that are not within the control of Genmab or the license and collaboration partner, such as regulatory approvals, are not considered probable of being achieved until those approvals are received. The transaction price is then allocated to each performance obligation on a relative stand-alone selling price basis, for which Genmab recognizes revenue as or when the performance obligations under the contract are satisfied. At the end of each subsequent reporting period, Genmab re-evaluates the probability of achievement of such development milestones and any related constraint, and if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative catch-up basis, which would affect revenue and earnings in the period of adjustment. Under all of Genmab's existing license and collaboration agreements, milestone payments have been allocated to the license transfer performance obligation.

**License Revenue for Intellectual Property:** If the license to Genmab's functional intellectual property is determined to be distinct from the other performance obligations identified in the arrangement, Genmab recognizes revenues from non-refundable upfront fees allocated to the license at the point in time the license is transferred to the licensee and the licensee is able to use and benefit from the license. For licenses that are bundled with other promises, Genmab utilizes judgement to assess the nature of the combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purposes of recognizing revenue from non-refundable, upfront fees. Under all of Genmab's existing license and collaboration agreements the license to functional intellectual property has been determined to be distinct from other performance obligations identified in the agreement.

**Collaboration Revenue:** Collaboration revenue includes net profit sharing arrangements for the sale of commercial products. When Genmab is determined to be the principal in sales to end customers, all product sales are included in net product sales in the income statement. As of December 31, 2022, Genmab has not recorded any net product sales. When Genmab's collaboration partner is determined to be the principal in sales to end customers, Genmab's share of net profits for the sale of commercial products is included in collaboration revenue.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 87/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

Refer to Note 5.6 for detailed information regarding Genmab's significant Research Collaborations, License Agreements and Collaborative Agreements.

#### MANAGEMENT'S JUDGeMENTS AND ESTIMATES – revenue recognition
Evaluating the criteria for revenue recognition under license and collaboration agreements requires management's judgement to assess and determine the following:

● An estimation of partner net sales amounts in determination of the calculation of royalties.

● An assessment of whether the achievement of milestone payments is highly probable.

● An estimation of variable consideration identified in the contract using key assumptions which may include forecasted revenues, development timelines, reimbursement rates for personnel costs, discount rates and probabilities of technical and regulatory success.

● The nature of performance obligations and whether they are distinct or should be combined with other performance obligations to determine whether the performance obligations are satisfied over time or at a point in time.

2.2 – Information about Geographical Areas

Genmab is managed and operated as one business unit, which is reflected in the organizational structure and internal reporting. No separate lines of business or separate business entities have been identified with respect to any licensed products, marketed products, product candidates or geographical markets and no segment information is currently prepared for internal reporting.

Accordingly, it has been concluded that it is not relevant to include segment disclosures in the financial statements as Genmab's business activities are not organized on the basis of differences in related product and geographical areas.

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **Revenue** | **Non-current assets** | **Revenue** | **Non-current assets** | **Revenue** | **Non-current assets** |
| (DKK million) | 2022 | 2022 | 2021 | 2021 | 2020 | 2020 |
| Denmark | 14595 | 211 | 8482 | 269 | 10111 | 344 |
| Netherlands | - | 793 | - | 422 | - | 380 |
| United States | - | 442 | - | 470 | - | 370 |
| Japan | - | 70 | - | 95 | - | - |
| **Total** | **14595** | **1516** | **8482** | **1256** | **10111** | **1094** |

---

#### ACCOUNTING POLICIES
Geographical information is presented for Genmab's revenue and non-current assets. Revenue is attributed to countries on the basis of the location of the legal entity holding the contract with the counterparty. Non-current assets comprise intangible assets, property and equipment, right-of-use assets and receivables.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 88/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

2.3 – Staff Costs

---

| | | | |
|:---|:---|:---|:---|
|  | 2022 | 2021 | 2020 |
| (DKK million) |  |  |  |
| Wages and salaries | 1913 | 1174 | 694 |
| Share-based compensation | 439 | 310 | 200 |
| Defined contribution plans | 112 | 80 | 51 |
| Other social security costs | 263 | 155 | 108 |
| Government grants | (144) | (122) | (119) |
| **Total**  | **2583** | **1597** | **934** |
| **Staff costs are included in the income statement as follows:** |  |  |  |
| Research and development expenses | 1662 | 1190 | 803 |
| Selling, general and administrative expenses | 1065 | 529 | 250 |
| Government grants related to research and development expenses | (144) | (122) | (119) |
| **Total** | **2583** | **1597** | **934** |
| **Average number of FTE** | **1460** | **1022** | **656** |
| **Number of FTE at year-end** | **1660** | **1212** | **781** |

---

Refer to Note 4.6 for additional information regarding share-based instruments and Note 5.1 for additional information regarding the remuneration of the Board of Directors and Executive Management.

#### STAFF COSTs
Wages and salaries, other social security costs, paid leave and bonuses, and other employee benefits are recognized in the financial year in which the employee performs the associated work.

Genmab's pension plans are classified as defined contribution plans and, accordingly, no pension obligations are recognized in the balance sheet. Costs relating to defined contribution plans are included in the income statement in the period in which they are accrued, and outstanding contributions are included in other payables.

Termination benefits are recognized as an expense, when Genmab is committed demonstrably, without realistic possibility of withdrawal, to a formal detailed plan to terminate employment.

#### GOVERNMENT GRANTS
The Dutch Research and Development Act "WBSO" provides compensation for a part of research and development wages and other costs through a reduction in payroll taxes. WBSO grant amounts are offset against wages and salaries and included in research and development expenses in the income statement.

2.4 – Corporate and Deferred Tax

#### TAXATION – INCOME STATEMENT & SHAREHOLDERS' EQUITY

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 89/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

---

| | | | |
|:---|:---|:---|:---|
|  | 2022 | 2021 | 2020 |
| (DKK million) |  |  |  |
| Current tax on profit  | 1498 | 968 | 1191 |
| Adjustment to deferred tax | 107 | (371) | (112) |
| Adjustment to unrecognized deferred tax assets | (92) | 378 | 67 |
| **Total tax for the period in the income statement** | **1513** | **975** | **1146** |
|  | 2022 | 2021 | 2020 |
| (DKK million) |  |  |  |
| Net profit before tax | 7035 | 3983 | 5904 |
| **Tax at the Danish corporation tax rate of 22% for all periods** | **1548** | **876** | **1299** |
| **Tax effect of:** |  |  |  |
| Adjustment to unrecognized deferred tax assets | (92) | 137 | 67 |
| Recognition of previously unrecognized tax losses and deductible temporary differences | (12) | 119 | (222) |
| Non-deductible expenses/non-taxable income and other permanent differences, net | 73 | (147) | (5) |
| All other | (4) | (10) | 7 |
| **Total tax effect** | **(35)** | **99** | **(153)** |
| **Total tax for the period in the income statement** | **1513** | **975** | **1146** |
| **Total tax for the period in shareholders' equity** | **(22)** | **(31)** | **(44)** |
| **Effective Tax Rate** | **21.5%** | **24.5%** | **19.4%** |

---

Corporate tax consists of current tax and the adjustment of deferred taxes during the year. The corporate tax expense was DKK 1,513 million in 2022, DKK 975 million in 2021 and DKK 1,146 million in 2020. Tax expenses of DKK 22 million, DKK 31 million, and DKK 44 million related to excess tax benefits for share-based compensation were recorded directly in shareholders' equity, in 2022, 2021, and 2020, respectively.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 90/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### TAXATION – BALANCE SHEET
Significant components of the deferred tax asset are as follows:

---

| | | |
|:---|:---|:---|
|  | 2022 | 2021 |
| (DKK million) |  |  |
| Share-based instruments | 128 | 136 |
| Deferred revenue | 113 | 113 |
| Other temporary differences | 11 | 15 |
| **Total Deferred Taxes** | **252** | **264** |

---

Genmab recognizes deferred tax assets if it is probable that sufficient taxable income will be available in the future, against which the temporary differences and unused tax losses can be utilized. Management has considered future taxable income and applied its judgement in assessing whether deferred tax assets should be recognized.

As of December 31, 2022, and 2021, Genmab had gross tax loss carryforwards of DKK 3.2 billion and DKK 2.7 billion, respectively, to reduce future taxable income in the U.S. and the Netherlands. The loss carryforwards generally expire in various periods through 2037; however, U.S. tax losses originating after 2017 and tax losses in the Netherlands available as of December 31, 2022, can be carried forward indefinitely.

#### ACCOUNTING POLICIES

#### CORPORATE TAX
Corporate tax, which consists of current tax and deferred taxes for the year, is recognized in the income statement, except to the extent that the tax is attributable to items which directly relate to shareholders' equity or other comprehensive income.

Current tax assets and liabilities for current and prior periods are measured at the amounts expected to be recovered from or paid to the tax authorities.

#### DEFERRED TAX
Deferred tax accounting requires recognition of deferred tax on all temporary differences between the carrying amount of assets and liabilities and the tax base of such assets and liabilities. This includes the tax value of certain tax losses carried forward.

Deferred tax is calculated in accordance with the tax regulations in the local countries and the tax rates expected to be in force at the time the deferred tax is utilized. Changes in deferred tax as a result of changes in tax rates are recognized in the income statement.

Deferred tax assets resulting from temporary differences, including the tax value of losses to be carried forward, are recognized only to the extent that it is probable that future taxable profit will be available against which the differences can be utilized.

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| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 91/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### MANAGEMENT'S JUDGeMENTS AND ESTIMATES

#### DEFERRED TAX
Genmab recognizes deferred tax assets if management assesses that these tax assets can be offset against positive taxable income within a foreseeable future. This judgement is made on an ongoing basis and is based on numerous factors, including actual results, budgets and business plans for the coming years.

Realization of deferred tax assets is dependent upon a number of factors, including future taxable earnings, the timing and amount of which are highly uncertain. A significant portion of Genmab's future taxable income will be driven by future events that are highly susceptible to factors outside the control of Genmab including commercial growth of DARZALEX, specific clinical outcomes, regulatory approvals, advancement of Genmab's product pipeline and other matters. Genmab continues to maintain nonrecognition of a significant portion of deferred tax assets related to its subsidiaries until there is sufficient evidence to support the recognition of deferred tax assets. Genmab may recognize deferred tax assets related to its subsidiaries in the future. The recognition of deferred tax assets will result in a decrease to income tax expense in such period.

2.5 – Profit Per Share

---

| | | | |
|:---|:---|:---|:---|
| **(DKK million)** | **2022** | **2021** | **2020** |
| **Net profit** | 5522 | 3008 | 4758 |
| **(Shares)** |  |  |  |
| Average number of shares outstanding | 65783130 | 65634300 | 65315975 |
| Average number of treasury shares | (395829) | (238663) | (136969) |
| **Average number of shares excl. treasury shares** | **65387301** | **65395637** | **65179006** |
| Average number of share-based instruments, dilution | 622303 | 650114 | 706869 |
| **Average number of shares, diluted** | **66009604** | **66045751** | **65885875** |
| Basic net profit per share | 84.45 | 46.00 | 73.00 |
| Diluted net profit per share | 83.65 | 45.54 | 72.21 |

---

In the calculation of the diluted net profit per share for 2022, 68,728 warrants (none of which were vested) have been excluded as these share-based instruments are out of the money, compared to 43,654 and 68,605 (none of which were vested) for 2021 and 2020, respectively.

#### ACCOUNTING POLICIES

#### BASIC NET PROFIT PER SHARE
Basic net profit per share is calculated as the net profit for the period divided by the weighted average number of outstanding ordinary shares, excluding treasury shares.

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| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 92/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### DILUTED NET PROFIT PER SHARE
Diluted net profit per share is calculated as the net profit for the period divided by the weighted average number of outstanding ordinary shares, excluding treasury shares and adjusted for the dilutive effect of share equivalents.

### Section 3 – Operating Assets and Liabilities
**This section covers the operating assets and related liabilities that form the basis for Genmab's activities. Deferred tax assets and liabilities are included in Note 2.4. Assets related to Genmab's financing activities are shown in section 4.**

3.1 – Intangible Assets

---

| | | |
|:---|:---|:---|
|  | **Licenses, Rights, and Patents** | **Licenses, Rights, and Patents** |
| (DKK million) | **2022** | **2021** |
| Cost at January 1 | 891 | 891 |
| **Cost at December 31** | **891** | **891** |
| Accumulated amortization and impairment at January 1 | (637) | (553) |
| Amortization for the year | (70) | (84) |
| Impairment for the year | (38) | - |
| **Accumulated amortization and impairment at December 31** | **(745)** | **(637)** |
| **Carrying amount of Intangible Assets at December 31** | **146** | **254** |

---

---

| | | | |
|:---|:---|:---|:---|
| (DKK million) | **2022** | **2021** | **2020** |
| **Amortization and impairment included in the income statement as follows:** |  |  |  |
| Research and development expenses | 108 | 84 | 131 |
| **Total** | **108** | **84** | **131** |

---

#### ACCOUNTING POLICIES

#### RESEARCH AND DEVELOPMENT PROJECTS
Internal and subcontracted research costs are charged in full to the income statement in the period in which they are incurred. Consistent with industry practice, development costs are also expensed until regulatory approval is obtained or is probable. Genmab has no internally generated intangible assets from development, as the criteria for recognition of an intangible asset are not met.

#### LICENSES AND RIGHTS
Genmab acquires licenses and rights primarily to gain access to targets and technologies identified by third parties. Payments to third parties under collaboration and license agreements are assessed to determine whether such payments should be expensed as incurred as research and development expenses or capitalized as an intangible asset.

Licenses and rights that meet the criteria for capitalization as intangible assets are measured at cost less accumulated amortization and any impairment losses. Milestone payments related to capitalized licenses and rights are accounted for as an increase in the cost to acquire licenses and rights.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 93/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### Amortization
Amortization is based on the straight-line method over the estimated useful life. This corresponds to the legal duration or the economic useful life depending on which is shorter. The amortization of intellectual property rights commences after regulatory approval has been obtained or when assets are put in use.

#### MANAGEMENT'S JUDGEMENTS AND ESTIMATES

#### Impairment
If circumstances or changes in Genmab's operations indicate that the carrying amount of intangible assets may not be recoverable, management reviews the asset for impairment. The basis for the review is the recoverable amount of the intangible assets, determined as the greater of the fair value less cost to sell or its value in use. Value in use is calculated as the net present value of future cash inflow generated from the intangible asset. If the carrying amount of an intangible asset is greater than the recoverable amount, the intangible asset is written down to the recoverable amount. An impairment loss is recognized in the income statement when the impairment is identified. Impairments on intangible assets are reviewed at each reporting date for possible reversal.

Amortization, impairment losses, and gains or losses on the disposal of intangible assets related to licenses and rights are recognized in the income statement as research and development expenses.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 94/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

**3.2 – Property and Equipment**

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **Leasehold improvements** | **Equipment, furniture and fixtures** | **Assets under construction** | **Total property and equipment** |
| **(DKK million)** |  |  |  |  |
| **2022** |  |  |  |  |
| Cost at January 1 | 400 | 537 | 52 | 989 |
| Additions for the year | 5 | 118 | 181 | 304 |
| Disposals for the year | (8) | (13) | - | (21) |
| Exchange rate adjustment | 15 | 7 | - | 22 |
| **Cost at December 31** | **412** | **649** | **233** | **1294** |
| Accumulated depreciation and impairment at January 1 | (90) | (278) | - | (368) |
| Depreciation for the year | (52) | (94) | - | (146) |
| Exchange rate adjustment | (1) | (2) | - | (3) |
| Accumulated depreciation on disposals | 11 | 11 | - | 22 |
| **Accumulated depreciation and impairment at December 31** | **(132)** | **(363)** | **-** | **(495)** |
|  |  |  |  | . |
| **Carrying amount at December 31** | **280** | **286** | **233** | **799** |
|  | **Leasehold improvements** | **Equipment, furniture and fixtures** | **Assets under construction** | **Total property and equipment** |
| **(DKK million)** |  |  |  |  |
| **2021** |  |  |  |  |
| Cost at January 1 | 287 | 416 | 14 | 717 |
| Additions for the year | 29 | 120 | 111 | 260 |
| Transfers between the classes | 70 | 3 | (73) | - |
| Disposals for the year | - | (9) | - | (9) |
| Exchange rate adjustment | 14 | 7 | - | 21 |
| **Cost at December 31** | **400** | **537** | **52** | **989** |
| Accumulated depreciation and impairment at January 1 | (43) | (221) | - | (264) |
| Depreciation for the year | (46) | (64) | - | (110) |
| Exchange rate adjustment | (1) | (2) | - | (3) |
| Accumulated depreciation on disposals | - | 9 | - | 9 |
| **Accumulated depreciation and impairment at December 31** | **(90)** | **(278)** | **-** | **(368)** |
|  |  |  |  | . |
| **Carrying amount at December 31** | **310** | **259** | **52** | **621** |
|  |  | **2022** | **2021** | **2020** |
| **(DKK million)** |  |  |  |  |
| **Depreciation and impairment included in the income statement as follows:** |  |  |  |  |
| Research and development expenses |  | 108 | 93 | 69 |
| Selling, general and administrative expenses |  | 38 | 17 | 10 |
| **Total** |  | **146** | **110** | **79** |

---

Capital expenditures in 2022 and 2021 were primarily related to the expansion of our facilities in the Netherlands and the U.S. to support the growth in our product pipeline.

#### ACCOUNTING POLICIES
Property and equipment is comprised of leasehold improvements, assets under construction, and equipment, furniture and fixtures, which are measured at cost less accumulated depreciation and any impairment losses.

The cost is comprised of the acquisition price and direct costs related to the acquisition until the asset is ready for use. Costs include direct costs and costs to subcontractors.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 95/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### DEPRECIATION
Depreciation is calculated on a straight-line basis to allocate the cost of the assets, net of any residual value, over the estimated useful lives, which are as follows:

---

| | |
|:---|:---|
| &nbsp;&nbsp;Equipment, furniture and fixtures | &nbsp;&nbsp;3-5 years |
| &nbsp;&nbsp;Computer equipment | &nbsp;&nbsp;3 years |
| &nbsp;&nbsp;Leasehold improvements | &nbsp;&nbsp;15 years<br>or the lease term, if shorter |

---

Depreciation commences when the asset is available for use, including when it is in the location and condition necessary for it to be capable of operating in the manner intended by management. The useful lives and residual values are reviewed and adjusted if appropriate on a yearly basis. Assets under construction are not depreciated.

#### IMPAIRMENT
If circumstances or changes in Genmab's operations indicate that the carrying amount of property and equipment may not be recoverable, management reviews the asset for impairment.

The basis for the review is the recoverable amount of the asset, determined as the greater of the fair value less cost to sell or its value in use. Value in use is calculated as the net present value of future cash inflow generated from the asset.

If the carrying amount of an asset is greater than the recoverable amount, the asset is written down to the recoverable amount. An impairment loss is recognized in the income statement when the impairment is identified.

3.3 - Leases

Genmab has entered into lease agreements with respect to office and laboratory space, and IT equipment. The expense, lease liability, and right-of-use assets balances related to IT equipment are immaterial. The leases are non-cancellable over various periods through 2038.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 96/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

---

| | | | |
|:---|:---|:---|:---|
|  | **December 31,** | **December 31,** | **December 31,** |
| **(DKK million)** | **2022** | **2021** | **2020** |
| **Right-of-use assets** |  |  |  |
| Balance at January 1 | 354 | 283 | 177 |
| Additions to right-of-use assets<sup>1</sup> | 243 | 127 | 142 |
| Depreciation charge for the year | (74) | (56) | (36) |
| **Balance at December 31** | **523** | **354** | **283** |
| **Lease liabilities** |  |  |  |
| Current | 74 | 62 | 42 |
| Non-current | 523 | 363 | 277 |
| **Total lease liabilities** | **597** | **425** | **319** |
| <sup>(1) Additions to right-of-use assets also includes modifications to existing leases and adjustments to the provisions for contractual restoration obligations related to leases of Genmab offices.</sup> |  |  |  |
| **Cash outflow for lease payments** | **88** | **70** | **53** |

---

Variable lease payments, short-term leases, lease interest expense, and sublease income are immaterial.

Future minimum payments under leases as of December 31, 2022, December 31, 2021, and December 31, 2020, are as follows:

---

| | | | |
|:---|:---|:---|:---|
| **(DKK million)** | **2022** | **2021** | **2020** |
| **Payment due**  |  |  |  |
| Less than 1 year | 89 | 74 | 53 |
| 1 to 3 years | 167 | 109 | 85 |
| More than 3 years but less than 5 years  | 136 | 97 | 62 |
| More than 5 years  | 271 | 207 | 194 |
| Total | **663** | **487** | **394** |

---

Future minimum payments under our leases with commencement dates after December 31, 2022 are not included in the table above.

**Significant Leases Not Yet Commenced**

During 2020, Genmab entered into a lease agreement with respect to the new headquarters in Denmark with a commencement date in March 2023 and is non-cancellable until March 2038. The total future minimum payments over the term of the lease are approximately DKK 339 million and estimated capital expenditures to fit out the space are approximately DKK 128 million.

---

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|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 97/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### ACCOUNTING POLICIES
All leases are recognized in the balance sheet as a right-of-use ("ROU") asset with a corresponding lease liability, except for short-term leases in which the term is 12 months or less, or low-value leases.

ROU assets represent Genmab's right to use an underlying asset for the lease term and lease liabilities represent Genmab's obligation to make lease payments arising from the lease. The ROU asset is depreciated over the shorter of the asset's useful life or the lease term on a straight-line basis. In the income statement, lease costs are replaced by depreciation of the ROU asset recognized over the lease term in operating expenses, and interest expenses related to the lease liability are classified in financial items.

Genmab determines if an arrangement is a lease at inception. Genmab leases various properties and IT equipment. Rental contracts are typically made for fixed periods. Lease terms are negotiated on an individual basis and contain a wide range of terms and conditions.

Assets and liabilities arising from a lease are initially measured on a present value basis. Lease liabilities include the net present value of fixed payments, less any lease incentives. As Genmab's leases generally do not provide an implicit interest rate, Genmab uses an incremental borrowing rate based on the information available at the commencement date of the lease in determining the present value of lease payments. Lease terms utilized by Genmab may include options to extend or terminate the lease when it is reasonably certain that Genmab will exercise that option. In determining the lease term, management considers all facts and circumstances that create an economic incentive to exercise an extension option, or not exercise a termination option. Extension options (or periods after termination options) are only included in the lease term if the lease is reasonably certain to be extended.

ROU assets are measured at cost and include the amount of the initial measurement of the lease liability, any lease payments made at or before the commencement date less any lease incentives received, any initial direct costs, and restoration costs.

Payments associated with short-term leases and leases of low-value assets are recognized on a straight-line basis as an expense in the income statement.

3.4 - Other Investments

---

| | | |
|:---|:---|:---|
|  | **December 31,** | **December 31,** |
| **(DKK million)** | **2022** | **2021** |
| Publicly traded equity securities | 67 | 344 |
| Fund investments | 66 | 27 |
| **Total other investments** | **133** | **371** |

---

Other investments include investments in publicly traded common stock of companies, including common stock of companies with whom Genmab has entered into collaboration arrangements, as well as investments in certain strategic investment funds. The decrease in other investments was primarily driven by the decrease in fair value of Genmab's investment in common shares of CureVac N.V ("CureVac").

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| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 98/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

Other investments are measured on initial recognition at fair value, and subsequently at fair value. Changes in fair value are recognized in the income statement within financial income or expense.

3.5 – Receivables

---

| | | |
|:---|:---|:---|
|  | 2022 | 2021 |
| (DKK million) |  |  |
| Receivables related to collaboration agreements | 5266 | 2979 |
| Interest receivables | 82 | 37 |
| Other receivables  | 176 | 160 |
| Receivables for securities matured | 290 | - |
| Prepayments | 144 | 218 |
| **Total at December 31** | **5958**  | **3394**  |
| Non-current receivables | 48 | 27 |
| Current receivables  | 5910 | 3367 |
| **Total at December 31** | **5958**  | **3394**  |

---

During 2022 and 2021, there were no losses related to receivables and the credit risk on receivables is considered to be limited. The provision for expected credit losses was not significant given that there have been no credit losses over the last three years and the high-quality nature (top tier life science companies) of Genmab's customers are not likely to result in future default risk.

The receivables are mainly comprised of royalties, milestones and amounts due under collaboration agreements and are non-interest bearing receivables which are due less than one year from the balance sheet date.

Refer to Note 4.2 for additional information about interest receivables and related credit risk.

Receivables are designated as financial assets measured at amortized cost and are initially measured at fair value or transaction price and subsequently measured in the balance sheet at amortized cost, which generally corresponds to nominal value less expected credit losses.

Genmab utilizes a simplified approach to measuring expected credit losses and uses a lifetime expected loss allowance for all receivables. To measure the expected credit losses, receivables have been grouped based on credit risk characteristics and the days past due.

Prepayments include expenditures related to a future financial period. Prepayments are measured at nominal value.

3.6 – Deferred Revenue

Genmab has recognized the following liabilities related to the AbbVie collaboration agreement.

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| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 99/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

---

| | | |
|:---|:---|:---|
| **(DKK million)** | **2022** | **2021** |
| Deferred revenue at January 1 | 513 | 513 |
| Payment received | - | - |
| Revenue recognized during the year | - | - |
| **Total at December 31** | **513**  | **513** |
| Non-current deferred revenue | 480 | 487 |
| Current deferred revenue | 33 | 26 |
| **Total at December 31** | **513**  | **513** |

---

Deferred revenue was recognized in connection with the AbbVie collaboration agreement. An upfront payment of USD 750 million (DKK 4,911 million) was received in July 2020 of which DKK 4,398 million was recognized as license revenue during 2020.

The revenue deferred at the initiation of the AbbVie agreement in June 2020 related to four product concepts to be identified and controlled under a research agreement to be negotiated between Genmab and AbbVie. One of the product concepts will comprise of or contain Genmab antibodies conjugated with AbbVie's payload linker technology and the other three product concepts will comprise of or contain CD3 DuoBody bispecific antibodies and AbbVie proprietary antibodies.

During the first quarter of 2022, Genmab and AbbVie entered into the aforementioned research agreement that governs the research and development activities in regard to the product concepts.

As of December 31, 2022, two of the four product concepts have been selected for research and development. As part of the continued evaluation of deferred revenue related to the AbbVie collaboration agreement, Genmab's classification of deferred revenue reflects the current estimate of co-development activities related to these product concepts as of December 31, 2022. None of the deferred revenue was recognized as reimbursement revenue in 2022, 2021 or 2020.

Refer to Note 2.1 for additional information related to the AbbVie collaboration.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 100/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

3.7 – Other Payables

---

| | | |
|:---|:---|:---|
| **(DKK million)** | **2022** | **2021** |
| Liabilities related to collaboration agreements | 70 | 53  |
| Staff cost liabilities  | 481 | 296  |
| Other liabilities  | 919 | 781  |
| Provisions | 12 | 13  |
| Accounts payable | 245 | 350  |
| **Total at December 31** | **1727**  | **1493**  |
| Non-current other payables  | 11 | 13 |
| Current other payables  | 1716 | 1480 |
| **Total at December 31** | **1727**  | **1493**  |

---

**ACCOUNTING POLICIES**

Other payables, excluding provisions, are initially measured at fair value and subsequently measured in the balance sheet at amortized cost.

The current other payables are comprised of liabilities that are due less than one year from the balance sheet date and are in general not interest bearing and settled on an ongoing basis during the next financial year.

Non-current payables are measured at the present value of the expenditures expected to be required to settle the obligation using a pre-tax discount rate that reflects current market assessments of the time value of money and the risks specific to the obligation. The increase in the liability due to passage of time is recognized as interest expense.

#### ACCOUNTS PAYABLE
Accounts payable are measured in the balance sheet at amortized cost.

#### OTHER LIABILITIES
Other liabilities primarily include accrued expenses related to our research and development project costs.

Refer to Note 2.3 for accounting policies related to staff costs.

### Section 4 – Capital Structure, Financial Risk and Related Items
**This section includes disclosures related to how Genmab manages its capital structure, cash position and related risks and items. Genmab is primarily financed through partnership collaborations.**

4.1 – Capital Management

Genmab's goal is to maintain a strong capital base so as to maintain investor, creditor and market confidence, and a continuous advancement of Genmab's product pipeline and business in general.

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| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 101/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

Genmab is primarily financed through revenues under various collaboration agreements and had, as of December 31, 2022, cash and cash equivalents of DKK 9,893 million and marketable securities of DKK 12,431 million compared to DKK 8,957 million and DKK 10,381 million, respectively, as of December 31, 2021. Genmab's cash and cash equivalents and marketable securities support the advancement of our product pipeline and operations.

The adequacy of our available funds will depend on many factors, including the level of DARZALEX and other royalty streams, progress in our research and development programs, the magnitude of those programs, our commitments to existing and new clinical collaborators, our ability to establish commercial and licensing arrangements, our capital expenditures, market developments, and any future acquisitions. Accordingly, Genmab may require additional funds and may attempt to raise additional funds through equity or debt financings, collaborative agreements with partners, or from other sources.

The Board of Directors monitors the share and capital structure to ensure that Genmab's capital resources support its strategic goals.

Neither Genmab A/S nor any of its subsidiaries are subject to externally imposed capital requirements.

4.2 – Financial Risk

The financial risks of the Genmab Group are managed centrally.

The overall risk management guidelines have been approved by the Board of Directors and include the Group's investment policy related to our marketable securities. The Group's risk management guidelines are established to identify and analyze the risks faced by the Genmab Group, to set the appropriate risk limits and controls and to monitor the risks and adherence to limits. It is Genmab's policy not to actively speculate in financial risks. The Group's financial risk management is directed solely towards monitoring and reducing financial risks which are directly related to Genmab's operations.

The primary objective of Genmab's investment activities is to preserve capital and ensure liquidity with a secondary objective of maximizing the return derived from security investments without significantly increasing risk. Therefore, our investment policy includes among other items, guidelines and ranges for which investments (which are primarily shorter-term in nature) are considered to be eligible investments for Genmab and which investment parameters are to be applied, including maturity limitations and credit ratings. In addition, the policy includes specific diversification criteria and investment limits to minimize the risk of loss resulting from over concentration of assets in a specific class, issuer, currency, country, or economic sector.

Genmab's marketable securities are administrated by external investment managers. The investment guidelines and managers are reviewed regularly to reflect changes in market conditions, Genmab's activities and financial position. At the beginning of 2021, Genmab's investment policy was amended to allow investments in debt rated BBB- or greater by S&P or Fitch and in debt rated Baa3 or greater by Moody's. The amended policy also includes additional allowable investment types such as corporate debt, commercial paper, certificates of deposit, and certain types of AAA rated asset-backed securities.

In addition to the capital management and financing risk mentioned in Note 4.1, Genmab has identified the following key financial risk areas, which are mainly related to our marketable securities portfolio:

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| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 102/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

· credit risk; <br> ·foreign currency risk; and <br> <u>·interest rate risk</u>

All of Genmab's marketable securities are traded in established markets. Given the current market conditions, all future cash inflows including re-investments of proceeds from the disposal of marketable securities are invested in highly liquid, investment grade securities. Refer to Note 4.4 for additional information regarding marketable securities.

#### CREDIT RISK
Genmab is exposed to credit risk and losses on marketable securities and bank deposits. The maximum credit exposure related to Genmab's cash and cash equivalents and marketable securities was DKK 22,324 million as of December 31, 2022 compared to DKK 19,338 million as of December 31, 2021. The maximum credit exposure to Genmab's receivables was DKK 5,958 million as of December 31, 2022 compared to DKK 3,394 million as of December 31, 2021.

#### Marketable Securities
To manage and reduce credit risks on our securities, Genmab's policy is to ensure only securities from investment grade issuers are eligible for our portfolios. No issuer of marketable securities can be accepted if the issuer, at the time of purchase, does not have the credit quality equal to or better than the rating shown in the table below from at least one of the rating agencies. If an issuer is rated by more than one of the rating agencies listed below, the credit assessment is made against the lowest rating available for the issuer.

---

| | | | |
|:---|:---|:---|:---|
| &nbsp;&nbsp;**Category** | **S&P** | **Moody's** | **Fitch** |
| &nbsp;&nbsp;Short-term | A-2 | P-2 | F-2 |
| &nbsp;&nbsp;Long-term | BBB- | Baa3 | BBB- |

---

Genmab's current portfolio is spread over a number of different securities with a focus on liquidity and security. As of December 31, 2022, 75% of Genmab's marketable securities were long-term A rated or higher, or short-term A-1 / P-1 rated by S&P, Moody's or Fitch compared to 68% as of December 31, 2021. The total value of marketable securities amounted to DKK 12,431 million at the end of 2022 compared to DKK 10,381 million at the end of 2021.

#### Cash and Cash Equivalents
To reduce the credit risk on our bank deposits, Genmab's policy is only to invest its cash deposits with highly rated financial institutions. Currently, these financial institutions have a short-term Fitch and S&P rating of at least F-1 and A-1, respectively. In addition, Genmab maintains bank deposits at a level necessary to support the short-term funding requirements of Genmab. The total value of bank deposits including AAA rated money market funds and short-term marketable securities classified as cash equivalents amounted to DKK 9,893 million as of December 31, 2022 compared to DKK 8,957 million at the end of 2021. The increase was primarily driven by Genmab's increased profitability and foreign exchange movements which positively impacted our USD denominated cash and cash equivalents.

#### Receivables
The credit risk related to our receivables is not significant based on the high-quality nature of Genmab's collaboration partners. As disclosed in Note 2.1, Janssen, Roche, AbbVie and BioNTech are Genmab's primary partners in which receivables are established for royalties, milestone revenue and reimbursement revenue.

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| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 103/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### FOREIGN CURRENCY RISK
Genmab's presentation currency is the DKK; however, Genmab's revenues and expenses are in a number of different currencies. Consequently, there is a substantial risk of exchange rate fluctuations having an impact on Genmab's cash flows, profit (loss) and/or financial position in DKK.

The majority of Genmab's revenue is generated in USD. Exchange rate changes to the USD will result in changes to the translated value of future net profit before tax and cash flows. Genmab's revenue in USD was 89% of total revenue in 2022 as compared to 92% in 2021 and 95% in 2020.

Under our license agreement with Janssen for DARZALEX, for purposes of calculating royalties due to Genmab, DARZALEX net sales for non-U.S. dollar denominated currencies are translated to U.S. dollars at a specified annual Currency Hedge Rate. Movements in foreign exchanges against the annual Currency Hedge Rate will result in changes to royalties due to Genmab impacting net profit before tax and cash flows.

There is also exposure that exchange rate fluctuations may impact equity as part of the currency translation adjustments required to convert the investments in foreign subsidiaries from their respective functional currencies to the presentation currency during consolidation, however any such fluctuations would be immaterial. The foreign subsidiaries are not significantly affected by currency risks as both revenues and expenses are primarily settled in the foreign subsidiaries' functional currencies.

#### Assets and Liabilities in Foreign Currency
Genmab's marketable securities denominated in USD, DKK, EUR and GBP as a percentage of total marketable securities were as follows:

---

| | | |
|:---|:---|:---|
|  | December 31, <br>2022 | December 31, <br>2021 |
| Percent |  |  |
| USD | 80% | 75% |
| DKK | 12% | 16% |
| EUR | 7% | 8% |
| GBP | 1% | 1% |
| **Total** | **100**% | **100**% |

---

Genmab's USD currency exposure is mainly related to cash and cash equivalents, marketable securities, and receivables related to our collaborations with Janssen, AbbVie, Roche and Seagen. Significant changes in the exchange rate of USD to DKK could cause net profit before tax to change materially as gains and losses are recognized in the income statement. Based on the amount of assets and liabilities denominated in USD as of December 31, 2022 and 2021, a 10% increase/ decrease in the USD to DKK exchange rate is estimated to impact Genmab's net profit before tax by approximately DKK 2.2 billion and DKK 1.5 billion, respectively. The analysis assumes that all other variables, in particular interest rates, remain constant. The movements in the income statement and equity arise from monetary items (cash and cash equivalents, marketable securities, receivables and liabilities) where the functional currency of the entity differs from the currency that the monetary items are denominated in.

Genmab's EUR exposure is mainly related to our marketable securities, receivables under our collaboration with BioNTech, and other costs denominated in EUR. Since the introduction of the EUR in 1999, Denmark has committed to maintaining a central rate of 7.46 DKK to the EUR. This rate may fluctuate within a +/- 2.25% band. Should Denmark's policy toward the EUR change, the DKK values of our EUR denominated assets and costs could be materially different compared to what is calculated and reported under the existing

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| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 104/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

Danish policy toward the DKK/EUR. As of December 31, 2022 and 2021, Genmab's EUR exposure is not material.

Genmab's GBP currency exposure is mainly related to contracts and marketable securities denominated in GBP. As of December 31, 2022 and 2021, Genmab's GBP exposure is not material.

#### INTEREST RATE RISK
Genmab's exposure to interest rate risk is primarily related to marketable securities, as Genmab currently does not have significant interest-bearing debts.

#### Marketable Securities
The securities in which the Group has invested bear interest rate risk, as a change in market-derived interest rates may cause fluctuations in the fair value of the investments. In accordance with the objective of the investment activities, the portfolio of securities is monitored on a total return basis.

To control and minimize the interest rate risk, Genmab maintains an investment portfolio in a variety of securities with a relatively short effective duration with both fixed and variable interest rates.

A sensitivity analysis was performed on Genmab's marketable securities, and based on exposures in 2021 and 2022, a hypothetical +/- 1% interest rate change would not have resulted in a material change in the fair values of these financial instruments. Due to the short-term nature of the current investments and to the extent that Genmab is able to hold the investments to maturity, the current exposure to changes in fair value due to interest rate changes is considered to be insignificant compared to the fair value of the portfolio.

---

| | | |
|:---|:---|:---|
| **(DKK million)** | **2022** | **2021** |
| **Year of Maturity** |  |  |
| 2022 | - | 3372 |
| 2023 | 6254 | 3041 |
| 2024 | 3660 | 2654 |
| 2025 | 1801 | 448 |
| 2026 | 219 | 152 |
| 2027+ | 497 | 714 |
| **Total** | **12431** | **10381** |

---

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|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 105/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

4.3 —Financial Assets and Liabilities

#### CATEGORIES OF FINANCIAL ASSETS AND LIABILITIES

---

| | | | |
|:---|:---|:---|:---|
| **(DKK million)** | **Note** | **2022** | **2021** |
| **Financial assets measured at fair value through profit or loss** |  |  |  |
| Marketable securities | 4.4 | 12431 | 10381 |
| Other investments | 3.4 | 133 | 371 |
| **Financial assets measured at amortized cost** |  |  |  |
| Receivables excluding prepayments  | 3.5 | 5814 | 3176 |
| Cash and cash equivalents |  | 9893 | 8957 |
| **Financial liabilities measured at amortized cost:** |  |  |  |
| Other payables excluding provisions | 3.7 | (1715) | (1480) |
| Lease liabilities | 3.3 | (597) | (425) |

---

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| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 106/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### FAIR VALUE MEASUREMENT

---

| | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
|  |  | 2022 | 2022 | 2022 | 2022 | 2021 | 2021 | 2021 | 2021 |
| **(DKK million)** | **Note** | **Level 1** | **Level 2** | **Level 3** | **Total** | **Level 1** | **Level 2** | **Level 3** | **Total** |
| **Assets Measured at Fair Value** |  |  |  |  |  |  |  |  |  |
| Marketable securities  | 4.4 | 12431 | - | - | **12431** | 10381 | - | - | **10381** |
| Other investments | 3.4 | 67 | - | 66 | **133** | 344 | - | 27 | **371** |

---

#### Marketable Securities
Substantially all fair market values are determined by reference to external sources using unadjusted quoted prices in established markets for our marketable securities (Level 1).

#### Other Investments
The fair value of Genmab's investment in CureVac is determined using unadjusted quoted prices in established markets (Level 1).

There were no transfers into or out of Level 3 during 2021 or 2022. Acquisitions (capital calls) on Level 3 investments in 2021 and 2022 were as follows:

---

| | |
|:---|:---|
| **(DKK million)** | **Other Investments** |
| **Fair value at December 31, 2020** | **14** |
| Acquisitions | 13 |
| **Fair value at December 31, 2021** | **27** |
| Acquisitions | 39 |
| **Fair value at December 31, 2022** | **66** |

---

#### ACCOUNTING POLICIES

#### CLASSIFICATION OF CATEGORIES OF FINANCIAL ASSETS AND LIABILITIES
Genmab classifies its financial assets held into the following measurement categories:

● those to be measured subsequently at fair value (either through other comprehensive income, or through profit or loss), and

● those to be measured at amortized cost.

The classification depends on the business model for managing the financial assets and the contractual terms of the cash flows.

For assets measured at fair value, gains and losses will either be recorded in profit or loss or other comprehensive income.

Genmab reclassifies debt investments only when its business model for managing those assets changes.

Further details about the accounting policy for each of the categories are outlined in the respective notes.

#### FAIR VALUE MEASUREMENT
Genmab measures financial instruments, such as marketable securities, at fair value at each balance sheet date. Management assessed that the fair value of financial assets and liabilities measured at amortized cost

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 107/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

such as bank deposits, receivables and other payables approximate their carrying amounts largely due to the short-term maturities of these instruments.

Fair value is the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. The fair value measurement is based on the presumption that the transaction to sell the asset or transfer the liability takes place either:

● In the principal market for the asset or liability, or

● In the absence of a principal market, in the most advantageous market for the asset or liability.

The principal or the most advantageous market must be accessible by Genmab.

The fair value of an asset or a liability is measured using the assumptions that market participants would use when pricing the asset or liability, assuming that market participants act in their economic best interest.

Genmab uses valuation techniques that are appropriate in the circumstances and for which sufficient data are available to measure fair value, maximizing the use of relevant observable inputs and minimizing the use of unobservable inputs.

For financial instruments that are measured in the balance sheet at fair value, IFRS 13 requires disclosure of fair value measurements by level of the following fair value measurement hierarchy:

---

| |
|:---|
| <br>· Level 1 - Quoted prices (unadjusted) in active markets for identical assets or liabilities<br>|
| <br>· Level 2 - Inputs other than quoted prices included within level 1 that are observable for the asset or liability, either directly (that is, as prices) or indirectly (that is, derived from prices)<br>|
| <br>· Level 3 - Inputs for the asset or liability that are not based on observable market data (that is, unobservable inputs).<br>|

---

For assets and liabilities that are recognized in the financial statements on a recurring basis, Genmab determines whether transfers have occurred between levels in the hierarchy by re-assessing categorization (based on the lowest level input that is significant to the fair value measurement as a whole) at the end of each reporting period. Any transfers between the different levels are carried out at the end of the reporting period.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 108/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

4.4 – Marketable Securities

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **Market value**<br>**2022** | **Share %**<br> | **Market value**<br>**2021** | **Share %**<br> |
| (DKK million) |  |  |  |  |
| **USD portfolio** |  |  |  |  |
| Corporate bonds | 5091 | 41% | 5149 | 50% |
| US government bonds and treasury bills | 3067 | 25% | 1496 | 14% |
| Commercial paper | 807 | 6% | 528 | 5% |
| Other | 1023 | 8% | 608 | 6% |
| **Total USD portfolio** | **9988** | **80%** | **7781** | **75%** |
| **DKK portfolio** |  |  |  |  |
| Kingdom of Denmark bonds and treasury bills | 442 | 3% | 460 | 4% |
| Danish mortgage-backed securities | 1093 | 9% | 1203 | 12% |
| **Total DKK portfolio** | **1535** | **12%** | **1663** | **16%** |
| **EUR portfolio** |  |  |  |  |
| European government bonds and treasury bills | 832 | 7% | 856 | 8% |
| **GBP portfolio** |  |  |  |  |
| UK government bonds and treasury bills | 76 | 1% | 81 | 1% |
| **Total portfolio** | **12431** | **100%** | **10381** | **100%** |
| **Marketable securities** | **12431** |  | **10381** |  |

---

Refer to Note 4.2 for additional information regarding the risks related to our marketable securities.

#### ACCOUNTING POLICIES
Marketable securities consist of investments in securities with a maturity of ninety days or greater at the time of acquisition. Measurement of marketable securities depends on the business model for managing the asset and the cash flow characteristics of the asset. There are two measurement categories into which Genmab classifies its debt instruments:

● Amortized cost: Assets that are held for collection of contractual cash flows, where those cash flows represent solely payments of principal and interest, are measured at amortized cost. Interest income from these financial assets is included in finance income using the effective interest rate method. Any gain or loss arising on derecognition is recognized directly in profit or loss and presented in other gains/(losses), together with foreign exchange gains and losses. Impairment losses are presented as a separate line item in the statement of profit or loss.

● Fair value through profit and loss (FVPL): Assets that do not meet the criteria for amortized cost or fair value through other comprehensive income (FVOCI) are measured at FVPL. A gain or loss on a debt investment that is subsequently measured at FVPL is recognized in profit or loss and presented net within financial income or expenses in the period in which it arises.

Genmab's portfolio is managed and evaluated on a fair value basis in accordance with its stated investment guidelines and the information provided internally to management. This business model does not meet the criteria for amortized cost or FVOCI and as a result marketable securities are measured at FVPL. This classification is consistent with the prior year's classification.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 109/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

Genmab invests its cash in deposits with major financial institutions, in AAA rated money market funds, Danish mortgage bonds, investment grade rated corporate debt, commercial paper, certificates of deposit, certain types of AAA rated asset backed securities, U.S. Agency bonds, and notes issued by the Danish, European and U.S. governments. The securities can be purchased and sold using established markets.

Transactions are recognized at the trade date.

4.5 – Financial Income and Expenses

---

| | | | |
|:---|:---|:---|:---|
| **(DKK million)** | **2022** | **2021** | **2020** |
| **Financial income:** |  |  |  |
| Interest and other financial income | 324 | 197 | 184 |
| Gain on other investments, net | - | - | 965 |
| Foreign exchange rate gain, net | 1034 | 1470 | - |
| **Total financial income** | **1358** | **1667** | **1149** |
| **Financial expenses:** |  |  |  |
| Interest and other financial expenses | (21) | (13) | (10) |
| Loss on marketable securities, net | (361) | (246) | (92) |
| Loss on other investments, net | (298) | (443) | - |
| Foreign exchange rate loss, net | - | - | (1456) |
| **Total financial expenses** | **(680)** | **(702)** | **(1558)** |
| **Net financial items** | **678** | **965** | **(409)** |

---

#### INTEREST INCOME
Interest income was DKK 324 million in 2022 compared to DKK 197 million in 2021. The increase of DKK 127 million, or 64%, was driven by higher effective interest rates in the U.S., Europe and Denmark for the respective periods.

#### FOREIGN EXCHANGE RATE GAINS AND LOSSES
Foreign exchange rate gains of DKK 1,034 million in 2022 and DKK 1,470 million in 2021, and losses of DKK 1,456 million in 2020 were primarily driven by foreign exchange movements impacting Genmab's USD denominated marketable securities and cash and cash equivalents; in particular, the USD/DKK foreign exchange rates were as follows for each period:

---

| | | | |
|:---|:---|:---|:---|
|  | **December 31,**<br>**2022** | **December 31,**<br>**2021** | **December 31,**<br>**2020** |
| USD/DKK Foreign Exchange Rates | 6.9722 | 6.5612 | 6.0524 |
| % Increase/(Decrease) | 6% | 8% | (9)% |

---

Refer to Note 4.2 for additional information on foreign currency risk.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 110/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### marketable securities gains and losses
**Loss on marketable securities, net was DKK 361 million in 2022 and DKK 246 million in 2021. The increase in losses of DKK 115 million, or 47%, was primarily driven by higher interest rates on Genmab's Danish mortgage investments in 2022 as compared to 2021. Loss on marketable securities, net was DKK 246 million in 2021 and DKK 92 million in 2020. The increase in losses of DKK 154 million was primarily driven by the movements in interest rates in the U.S. and Europe in the respective periods.**

#### OTHER INVESTMENTS
Loss on other investments, net was DKK 298 million in 2022 and DKK 443 million in 2021, and gain on other investments, net was DKK 965 million in 2020. The losses and gains in the respective periods are primarily driven by the change in fair value of Genmab's investment in common shares of CureVac.

#### ACCOUNTING POLICIES
Financial income and expenses include interest as well as foreign exchange rate adjustments and gains and losses on marketable securities (designated as FVPL) and realized gains and losses and write-downs of other securities and equity interests (designated as available-for-sale financial assets).

Interest income is shown separately from gains and losses on marketable securities and other securities and equity interests.

4.6 – Share-Based Instruments

**Restricted Stock Unit Program**

Genmab A/S has established an RSU program (equity-settled share-based payment transactions) as an incentive for Genmab's employees, members of the Executive Management, and members of the Board of Directors. RSUs granted to Executive Management are performance-based.

RSUs are granted by the Board of Directors. RSU grants to members of the Board of Directors and members of the Executive Management are subject to the Remuneration Policy adopted at the Annual General Meeting.

See the table below for a summary of key terms of Genmab's RSU programs:

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 111/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

---

| | | |
|:---|:---|:---|
|  | &nbsp;&nbsp;**RSUs Granted in Periods** | &nbsp;&nbsp;**RSUs Granted in Periods** |
| &nbsp;&nbsp;**Key Terms** | &nbsp;&nbsp;**December 2019 - February 2021** | &nbsp;&nbsp;**From February 2021** |
| &nbsp;&nbsp;**Grants** | &nbsp;&nbsp;Granted at closing share price on the grant date.  | &nbsp;&nbsp;Granted at closing share price on the grant date.  |
| &nbsp;&nbsp;**Vesting (Settlement)** | &nbsp;&nbsp;Cliff vesting – RSUs become fully vested on the first banking day of the month following a period of 3 years from the grant date. <br>After RSUs vest, the holder receives one share in Genmab A/S for each RSU granted. In jurisdictions in which Genmab as an employer is required to withhold tax and settle with the tax authority on behalf of the employee, Genmab withholds the number of RSUs that are equal to the monetary value of the employee's tax obligation from the total number of RSUs that otherwise would have been issued to the employee upon vesting ("net settlement"). Genmab A/S may at its sole discretion in extraordinary circumstances choose to make a cash settlement instead of delivering shares. | &nbsp;&nbsp;Cliff vesting – RSUs become fully vested on the first banking day of the month following a period of 3 years from the grant date. <br>After RSUs vest, the holder receives one share in Genmab A/S for each RSU granted. In jurisdictions in which Genmab as an employer is required to withhold tax and settle with the tax authority on behalf of the employee, Genmab withholds the number of RSUs that are equal to the monetary value of the employee's tax obligation from the total number of RSUs that otherwise would have been issued to the employee upon vesting ("net settlement"). Genmab A/S may at its sole discretion in extraordinary circumstances choose to make a cash settlement instead of delivering shares. |
| &nbsp;&nbsp;**Leaver**  | &nbsp;&nbsp;Leavers – Forfeit all unvested RSUs except when due to retirement, death, serious sickness or serious injury, in which case granted but not yet vested RSUs shall remain outstanding and will be settled in accordance with their terms.<br>Notwithstanding the above, the December 2020 RSU grant to members of the Board of Directors was made subject to pro-rata vesting upon termination of board services.<br>Employees and Executive Management - RSUs remain outstanding and vest accordingly when the employment relationship is terminated by Genmab without cause. | &nbsp;&nbsp;Good-Leavers<sup>1</sup>- May maintain a pro-rata portion of unvested RSUs<br>Bad-Leavers<sup>2</sup> - Forfeit all unvested RSUs.<br>Death - Forfeit all unvested RSUs. |

---

*1 - "Good-Leaver" - Dismissal without cause or termination of employment due to the Genmab's material breach of the RSU or Warrant holder's employment terms, or if the participant is a member of the Board of Directors, if the membership of the Board of Directors ceases for any other reason than as a result of the participants death.*

*2 - "Bad-leaver" - Dismissed for cause or during the employment probationary period.*

The RSU program contains anti-dilution provisions if changes occur in Genmab's share capital prior to the vesting date and provisions to accelerate vesting of RSUs in the event of change of control as defined in the RSU program.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 112/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

**RSU Activity in 2022, 2021 and 2020**

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | Number of RSUs held by the Board of Directors | Number of RSUs held by the Executive Management | Number of RSUs held by employees | Number of RSUs held by former members of the Executive Management, Board of Directors and employees | Total RSUs | Weighted Average Fair Value - RSUs Granted - DKK |
| **Outstanding at January 1, 2020** | **19953** | **72865** | **208859** | **6230** | **307907** |  |
| Granted\* | 2929 | 9032 | 34431 | 130 | 46522 | 1927.83 |
| Settled | (6470) | (12253) | (22196) | (5936) | (46855) |  |
| Transferred | (2822) | (2334) | (22762) | 27918 | - |  |
| Cancelled | (1025) | (1128) | (958) | (10535) | (13646) |  |
| **Outstanding at December 31, 2020** | **12565** | **66182** | **197374** | **17807** | **293928** |  |
| **Outstanding at January 1, 2021** | **12565** | **66182** | **197374** | **17807** | **293928** |  |
| Granted\* | 3297 | 31417 | 146684 | 4817 | 186215 | 2236.44 |
| Settled | (3556) | (14089) | (35962) | (9967) | (63574) |  |
| Transferred | (688) | 5533 | (14810) | 9965 | - |  |
| Cancelled | (653) | - | (255) | (9670) | (10578) |  |
| **Outstanding at December 31, 2021** | **10965** | **89043** | **293031** | **12952** | **405991** |  |
| **Outstanding at January 1, 2022** | **10965** | **89043** | **293031** | **12952** | **405991** |  |
| Granted\* | 4295 | 40453 | 221000 | 6383 | 272131 | 2250.18 |
| Settled | (3420) | (17165) | (67945) | (12847) | (101377) |  |
| Transferred | (2368) | - | (13749) | 16117 | - |  |
| Cancelled | (653) | - | (9195) | (18759) | (28607) |  |
| **Outstanding at December 31, 2022** | **8819** | **112331** | **423142** | **3846** | **548138** |  |

---

\* RSUs held by the Board of Directors include RSUs granted to employee-elected Board Members as employees of Genmab A/S or its subsidiaries.

Refer to Note 5.1 for additional information regarding compensation of Executive Management and the Board of Directors.

**Warrant Program**

Genmab A/S has established a warrant program (equity-settled share-based payment transactions) as an incentive for all the Genmab Group's employees and members of the Executive Management.

Warrants are granted by the Board of Directors in accordance with authorizations given to it by Genmab A/S' shareholders.

Warrant grants to Executive Management are subject to Genmab's Remuneration Policy adopted at the Annual General Meeting.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 113/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

See the table below for a summary of key terms of Genmab's warrant programs:

---

| | | | |
|:---|:---|:---|:---|
|  | &nbsp;&nbsp;**Warrants Granted in Periods** | &nbsp;&nbsp;**Warrants Granted in Periods** | &nbsp;&nbsp;**Warrants Granted in Periods** |
| &nbsp;&nbsp;**Key Terms** | &nbsp;&nbsp;**April 2012 - March 2017** | &nbsp;&nbsp;**March 2017 - February 2021** | &nbsp;&nbsp;**From February 2021** |
| &nbsp;&nbsp;**Grants** | &nbsp;&nbsp;Granted at an exercise price equal to the closing share price on the grant date. | &nbsp;&nbsp;Granted at an exercise price equal to the closing share price on the grant date. | &nbsp;&nbsp;Granted at an exercise price equal to the closing share price on the grant date. |
| &nbsp;&nbsp;**Vesting (Exercisable)** | &nbsp;&nbsp;Annually over 4-year period (25% per year) | &nbsp;&nbsp;Cliff vesting over 3-year period (100% after 3 years) | &nbsp;&nbsp;Cliff vesting over 3-year period (100% after 3 years) |
| &nbsp;&nbsp;**Leaver** | &nbsp;&nbsp;Leavers - Forfeit all unvested warrants; however, may be able to exercise warrants on a regular schedule in instances where the employment relationship is terminated by Genmab without cause. | &nbsp;&nbsp;Leavers - Forfeit all unvested warrants; however, may be able to exercise warrants on a regular schedule in instances where the employment relationship is terminated by Genmab without cause. | &nbsp;&nbsp;Good-Leavers - May maintain a pro-rata portion of unvested warrants<br>Bad-Leavers - Forfeit all unvested warrants.<br>Death - Forfeit all unvested warrants. |
| &nbsp;&nbsp;**Lapse** | &nbsp;&nbsp;7th anniversary of grant date | &nbsp;&nbsp;7th anniversary of grant date | &nbsp;&nbsp;7th anniversary of grant date |

---

The warrant program contains anti-dilution provisions if changes occur in Genmab's share capital prior to the warrants being exercised and provisions to accelerate vesting of warrants in the event of change of control or certain other extraordinary transactions as defined in the warrant program.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 114/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

**Warrant Activity in 2022, 2021 and 2020**

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
|  | Number of warrants held by the Board of Directors | Number of warrants held by the Executive Management | Number of warrants held by employees | Number of warrants held by former members of the Executive Management, Board of Directors and employees | Total warrants | Weighted average exercise price - DKK | Weighted average share price at exercise date - DKK | Outstanding Warrants - % of Share Capital |
| **Outstanding at January 1, 2020** | **62334** | **347801** | **858973** | **144516** | **1413624** | **862.03** |  |  |
| Granted\* | - | 7771 | 110041 | 416 | 118228 | 2009.79 |  |  |
| Exercised  | (24438) | - | (122015) | (324793) | (471246) | 296.77 | **2035.29** |  |
| Expired | - | - | - | - | - | - |  |  |
| Cancelled | - | (28424) | (589) | (43125) | (72138) | 1157.54 |  |  |
| Transfers | (25955) | (186333) | (113833) | 326121 | - | - |  |  |
| **Outstanding at December 31, 2020** | **11941** | **140815** | **732577** | **103135** | **988468** | **1247.22** |  | **2%** |
| Exercisable at year end | 4192 | 83426 | 166402 | 92696 | 346716 | 935.60 |  |  |
| Exercisable warrants in the money at year end | 4192 | 83426 | 166402 | 92696 | 346716 | 935.60 |  |  |
| **Outstanding at January 1, 2021** | **11941** | **140815** | **732577** | **103135** | **988468** | **1247.22** |  |  |
| Granted\* | 1217 | 1287 | 167080 | 6400 | 175984 | 2282.35 |  |  |
| Exercised  | (2500) | (7250) | (105726) | (57232) | (172708) | 780.48 | **2439.80** |  |
| Expired | - | - | - | - | - | - |  |  |
| Cancelled | - | - | (477) | (22816) | (23293) | 1956.91 |  |  |
| Transfers | - | 24782 | (54454) | 29672 | - | - |  |  |
| **Outstanding at December 31, 2021** | **10658** | **159634** | **739000** | **59159** | **968451** | **1501.49** |  | **1%** |
| Exercisable at year end | 6594 | 135723 | 219386 | 50021 | 411724 | 1058.41 |  |  |
| Exercisable warrants in the money at year end | 6594 | 135723 | 219386 | 50021 | 411724 | 1058.41 |  |  |
| **Outstanding at January 1, 2022** | **10658** | **159634** | **739000** | **59159** | **968451** | **1501.49** |  |  |
| Granted\* | 1541 | - | 250005 | 7412 | 258958 | 2244.22 |  |  |
| Exercised  | (1558) | (29836) | (176948) | (34775) | (243117) | 1154.95 | **2815.33** |  |
| Expired | - | - | - | - | - | - |  |  |
| Cancelled | - | - | (13670) | (32654) | (46324) | 2029.00 |  |  |
| Transfers | (8721) | - | (25373) | 34094 | - | - |  |  |
| **Outstanding at December 31, 2022** | **1920** | **129798** | **773014** | **33236** | **937968** | **1770.31** |  | **1%** |
| Exercisable at year end | 617 | 118571 | 282296 | 32695 | 434179 | 1265.68 |  |  |
| Exercisable warrants in the money at year end | 617 | 118571 | 282296 | 32695 | 434179 | 1265.68 |  |  |

---

\* Warrants held by the Board of Directors include warrants granted to employee-elected Board Members as employees of Genmab A/S or its subsidiaries.

Refer to Note 5.1 for additional information regarding compensation of Executive Management and the Board of Directors.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 115/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### Weighted Average Outstanding Warrants at December 31, 2022

---

| | | | | |
|:---|:---|:---|:---|:---|
| Exercise price | Grant Date | Number of warrants outstanding | Weighted average remaining contractual life (in years) | Number of warrants exercisable |
| DKK |  |  |  |  |
| 815.50 | March 17, 2016 | 2725 | 0.21 | 2725 |
| 962.00 | June 7, 2018 | 4646 | 2.44 | 4646 |
| 1025.00 | December 10, 2018 | 109918 | 2.94 | 109918 |
| 1032.00 | December 15, 2017 | 63230 | 1.96 | 63230 |
| 1050.00 | September 21, 2018 | 14024 | 2.73 | 14024 |
| 1136.00 | October 6, 2016 | 2695 | 0.77 | 2695 |
| 1145.00 | December 15, 2016 | 14963 | 0.96 | 14963 |
| 1147.50 | June 6, 2019 | 9386 | 3.43 | 9386 |
| 1155.00 | March 29, 2019 | 5509 | 3.25 | 5509 |
| 1161.00 | March 1, 2019 | 10128 | 3.17 | 10128 |
| 1210.00 | April 10, 2018 | 7090 | 2.28 | 7090 |
| 1233.00 | June 9, 2016 | 3681 | 0.44 | 3681 |
| 1334.50 | October 11, 2019 | 32150 | 3.78 | 32150 |
| 1362.50 | March 26, 2020 | 30938 | 4.24 | - |
| 1402.00 | March 28, 2017 | 6837 | 1.24 | 6837 |
| 1408.00 | June 8, 2017 | 954 | 1.44 | 954 |
| 1424.00 | February 10, 2017 | 408 | 1.11 | 408 |
| 1427.00 | March 29, 2017 | 8400 | 1.25 | 8400 |
| 1432.00 | October 5, 2017 | 1994 | 1.76 | 1994 |
| 1615.00 | December 5, 2019 | 135441 | 3.93 | 135441 |
| 1948.00 | June 3, 2020 | 12961 | 4.43 | - |
| 2070.00 | February 26, 2021 | 90968 | 5.16 | - |
| 2103.00 | June 9, 2022 | 22221 | 6.44 | - |
| 2129.00 | January 25, 2022 | 15986 | 6.07 | - |
| 2148.00 | April 13, 2021 | 15097 | 5.29 | - |
| 2175.00 | February 25, 2022 | 166286 | 6.15 | - |
| 2317.00 | October 7, 2020 | 34109 | 4.77 | - |
| 2381.00 | December 15, 2020 | 22983 | 4.96 | - |
| 2408.00 | March 29, 2022 | 13459 | 6.25 | - |
| 2492.00 | January 28, 2021 | 10053 | 5.08 | - |
| 2585.00 | September 20, 2022 | 19644 | 6.72 | - |
| 2641.00 | November 22, 2021 | 6456 | 5.89 | - |
| 2698.00 | June 22, 2021 | 14216 | 5.48 | - |
| 2806.00 | October 7, 2021 | 19476 | 5.77 | - |
| 3172.00 | November 21, 2022 | 8936 | 6.89 | - |
| 1770.31 |  | 937968 | 4.40  | 434179 |

---

#### Weighted Average Outstanding Warrants at December 31, 2021

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 116/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

---

| | | | | |
|:---|:---|:---|:---|:---|
| Exercise price | Grant Date | Number of warrants outstanding | Weighted average remaining contractual life (in years) | Number of warrants exercisable |
| DKK |  |  |  |  |
| 466.20 | March 26, 2015 | 600 | 0.24 | 600 |
| 623.50 | June 11, 2015 | 650 | 0.45 | 650 |
| 636.50 | October 7, 2015 | 7700 | 0.77 | 7700 |
| 815.50 | March 17, 2016 | 5301 | 1.21 | 5301 |
| 939.50 | December 10, 2015 | 20612 | 0.94 | 20612 |
| 962.00 | June 7, 2018 | 6527 | 3.44 | 6527 |
| 1025.00 | December 10, 2018 | 169565 | 3.94 | 169565 |
| 1032.00 | December 15, 2017 | 79771 | 2.96 | 79771 |
| 1050.00 | September 21, 2018 | 16806 | 3.73 | 16806 |
| 1136.00 | October 6, 2016 | 10424 | 1.77 | 10424 |
| 1145.00 | December 15, 2016 | 53374 | 1.96 | 53374 |
| 1147.50 | June 6, 2019 | 17209 | 4.43 | - |
| 1155.00 | March 29, 2019 | 7662 | 4.25 | - |
| 1161.00 | March 1, 2019 | 19028 | 4.17 | - |
| 1210.00 | April 10, 2018 | 10189 | 3.28 | 10189 |
| 1233.00 | June 9, 2016 | 9030 | 1.44 | 9030 |
| 1334.50 | October 11, 2019 | 52223 | 4.78 | - |
| 1362.50 | March 26, 2020 | 32054 | 5.24 | - |
| 1402.00 | March 28, 2017 | 7110 | 2.24 | 7110 |
| 1408.00 | June 8, 2017 | 1274 | 2.44 | 1274 |
| 1424.00 | February 10, 2017 | 946 | 2.11 | 946 |
| 1427.00 | March 29, 2017 | 8400 | 2.25 | 8400 |
| 1432.00 | October 5, 2017 | 3445 | 2.76 | 3445 |
| 1615.00 | December 5, 2019 | 183240 | 4.93 | - |
| 1948.00 | June 3, 2020 | 14898 | 5.43 | - |
| 2070.00 | February 26, 2021 | 96840 | 6.16 | - |
| 2148.00 | April 13, 2021 | 16880 | 6.29 | - |
| 2317.00 | October 7, 2020 | 36949 | 5.77 | - |
| 2381.00 | December 15, 2020 | 23761 | 5.96 | - |
| 2492.00 | January 28, 2021 | 12329 | 6.08 | - |
| 2641.00 | November 22, 2021 | 6879 | 6.89 | - |
| 2698.00 | June 22, 2021 | 15261 | 6.48 | - |
| 2806.00 | October 7, 2021 | 21514 | 6.77 | - |
| 1501.49 |  | 968451 | 4.39 | 411724 |

---

#### ACCOUNTING POLICIES

#### SHARE-BASED COMPENSATION EXPENSES
Share-based compensation expense is recognized in the income statement based on the estimated fair value of the awards at grant date. Subsequently, the fair value is not remeasured. The expense recognized reflects an estimate of the number of awards expected to vest after taking into consideration an estimate of award forfeitures based on historical experience and is recognized on a straight-line basis over the requisite service

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 117/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

period, which is the vesting period. Genmab reassesses its estimate of the number of shares expected to vest periodically.

Management expectations related to the achievement of performance goals associated with performance based RSU grants is assessed periodically, and that assessment is used to determine whether such grants are expected to vest or if any revision to the current estimate is required. Genmab recognizes the impact of the revised estimate of the number of awards expected to vest, if any, as an adjustment to the income statement over the remaining vesting period. If performance-based milestones related to performance-based RSU grants are not met or not expected to be met, any share-based compensation expense recognized to date associated with grants that are not expected to vest will be reversed.

Share-based compensation expenses represent calculated values of warrants, RSUs and performance-based RSUs granted and do not represent actual cash expenditures. A corresponding amount is recognized in shareholders' equity as the warrant, RSU and performance-based RSU programs are designated as equity-settled share-based payment transactions.

#### MANAGEMENT'S JUDGeMENTS AND ESTIMATES

#### SHARE-BASED COMPENSATION EXPENSES
The fair value of each warrant granted during the year is calculated using the Black-Scholes pricing model. This pricing model requires the input of subjective assumptions such as:

---

| |
|:---|
| &nbsp;&nbsp;The **expected stock price volatility,** which is based upon the historical volatility of Genmab's stock price;  |
| &nbsp;&nbsp;The **risk-free interest rate,** which is determined as the interest rate on Danish government bonds (bullet issues) with a maturity of five years;  |
| &nbsp;&nbsp;The **expected life of warrants,** which is based on vesting terms, expected rate of exercise and life terms in the current warrant program. |

---

These assumptions can vary over time and can change the fair value of future warrants granted.

#### Valuation Assumptions for Warrants Granted in 2022, 2021 and 2020
The fair value of each warrant granted during the year is calculated using the Black-Scholes pricing model with the following assumptions:

---

| | | | |
|:---|:---|:---|:---|
| **Weighted average** | **2022** | **2021** | **2020** |
| Fair value per warrant on grant date | 664.08 | 701.82 | 631.51 |
| Share price  | 2244.22 | 2282.35 | 2009.79 |
| Exercise price  | 2244.22 | 2282.35 | 2009.79 |
| Expected dividend yield | 0% | 0% | 0% |
| Expected stock price volatility | 33.5% | 36.6% | 37.0% |
| Risk-free interest rate | 0.15% | -0.54% | -0.58% |
| Expected life of warrants | 5 years | 5 years | 5 years |
| **Total Fair Value of Amounts Granted** | **2022** | **2021** | **2020** |
| Total fair value of warrants granted | DKK 172 million | DKK 124 million | DKK 75 million |
| Total fair value of RSUs granted | DKK 612 million | DKK 416 million | DKK 90 million |

---

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 118/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

4.7 – Share Capital

#### SHARE CAPITAL
The share capital comprises the nominal amount of Genmab A/S ordinary shares, each at a nominal value of DKK 1. All shares are fully paid.

As of December 31, 2022, the share capital of Genmab A/S comprised 65,961,573 shares of DKK 1 each with one vote. There are no restrictions related to the transferability of the shares. All shares are regarded as negotiable instruments and do not confer any special rights upon the holder, and no shareholder shall be under an obligation to allow his/her shares to be redeemed.

Genmab's Board of Directors is authorized to increase the share capital by subscription of new shares, issue warrants to subscribe for shares and raise loans against bonds as well as other financial instruments of Genmab A/S as set out in articles 4A-5B of Genmab A/S' Articles of Association. Further, Genmab's share capital is in compliance with the capital requirements of the Danish Companies Act and the rules of Nasdaq Copenhagen.

See table below for warrants issued and reissued and warrants available for reissue under active authorizations as of December 31, 2022:

---

| | | | |
|:---|:---|:---|:---|
|  | **April 13, 2021**<br>**Authorization** | **March 29, 2019**<br>**Authorization** | **March 28, 2017**<br>**Authorization** |
| Warrants issued | 68,291 | 500,000 | 500,000 |
| Warrants reissued | 1,333 | 59,671 | 63,558 |
| Warrants available for issue | 681,709 | - | - |
| Warrants available for reissue | 1,254 | 10,661 | - |

---

#### SHARE PREMIUM
The share premium reserve is comprised of the amount received, attributable to shareholders' equity, in excess of the nominal amount of the shares issued at the parent company's offerings, reduced by any external expenses directly attributable to the offerings. The share premium reserve can be distributed.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 119/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### CHANGES IN SHARE CAPITAL DURING 2020 TO 2022
The share capital of DKK 66 million at December 31, 2022 is divided into 65,961,573 shares at a nominal value of DKK 1 each.

---

| | | | |
|:---|:---|:---|:---|
|  | **Number of shares** | **Share capital** | **Share Price Ranges**<sup>1</sup> |
|  |  | (DKK million) |  |
| **December 31, 2019** | **65074502** | **65.1** |  |
| Exercise of warrants | 471246  | 0.4 | DKK 31.75 to DKK 1,432.00 |
| **December 31, 2020** | **65545748** | **65.5** |  |
| Exercise of warrants | 172708  | 0.2 | DKK 31.75 to DKK 1,432.00 |
| **December 31, 2021** | **65718456** | **65.7** |  |
| Exercise of warrants | 243117  | 0.3 | DKK 466.20 to DKK 1,615.00 |
| **December 31, 2022** | **65961573** | **66.0** |  |

---

*1 - New shares were subscribed at share prices in connection with the exercise of warrants under Genmab's warrant program.*

#### TREASURY SHARES

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | Number of shares | Share capital | Proportion of share capital | Cost |
|  |  | (DKK million) | % | (DKK million) |
| **Shareholding at December 31, 2019** | **163921** | **0.2** | **0.3** | **192** |
| Shares used for funding RSU program | (31815) | (0.1) | (0.1) | (38) |
| **Shareholding at December 31, 2020** | **132106** | **0.1** | **0.2** | **154** |
| Purchase of treasury shares | 200000  | 0.2  | 0.3  | 447  |
| Shares used for funding RSU program | (43781) | - | (0.1) | (51) |
| **Shareholding at December 31, 2021** | **288325** | **0.3** | **0.4** | **550** |
| Purchase of treasury shares | 370000  | 0.4 | 0.6  | 908  |
| Shares used for funding RSU program | (68377) | (0.1) | (0.1) | (80) |
| **Shareholding at December 31, 2022** | **589948** | **0.6** | **0.9** | **1378** |

---

**SHARE REPURCHASES**

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 120/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

Genmab intends to purchase its own shares primarily to cover obligations in relation to the share-based remuneration programs and reduce the dilution effect of share capital increases resulting from future exercises of warrants.

---

| | | | |
|:---|:---|:---|:---|
|  | **2021 Authorization** | **2019 Authorization** | **2016 Authorization** |
| Number of shares authorized for repurchase<sup>1</sup> | 500000 | 500000 | 500000 |
| Actual shares repurchased under authorization | 40000 | 500000 | 255000 |
| Shares available for repurchase as of December 31, 2022 | 460000 |  |  |
| <sup>1</sup> Nominal value of DKK 500,000 |  |  |  |

---

As announced on June 17, 2022, Genmab initiated a share buy-back program. During 2022, Genmab acquired 370,000 of its own shares, representing approximately 0.6% of share capital as of December 31, 2021. The total amount paid to acquire the shares, including directly attributable costs, was DKK 908 million and was recognized as a deduction to shareholders' equity. During 2021, Genmab acquired 200,000 of its own shares, representing approximately 0.3% of share capital as of December 31, 2020. The total amount paid to acquire the shares, including directly attributable costs, was DKK 447 million and was recognized as a deduction to shareholders' equity. These shares are classified as treasury shares and are presented within retained earnings on the balance sheet as of December 31, 2022.

As of December 31, 2022, 589,948 treasury shares were held by Genmab.

### Section 5 – Other Disclosures
**This section is comprised of various statutory disclosures or notes that are of secondary importance for the understanding of Genmab's financials.**

5.1 – Remuneration of the Board of Directors and Executive Management

The total remuneration of the Board of Directors and Executive Management is as follows:

---

| | | | |
|:---|:---|:---|:---|
| **(DKK million)** | **2022** | **2021** | **2020** |
| Wages and salaries | 55 | 51 | 48 |
| Share-based compensation expenses | 70 | 58 | 43 |
| Defined contribution plans | 2 | 2 | 2 |
| **Total** | **127**  | **111**  | **93**  |

---

The remuneration packages for the Board of Directors and Executive Management are described in further detail in Genmab's 2022 Compensation Report. The remuneration packages are denominated in DKK, EUR, or USD. The Compensation Committee of the Board of Directors performs an annual review of the remuneration packages. All incentive and variable remuneration is considered and adopted at the Company's Annual General Meeting.

Share-based compensation is included in the income statement and reported in the table above. Share-based compensation expense represents the estimated fair value of the awards at grant date and does not represent actual cash compensation received by the Board Members or Executive Management. Refer to

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 121/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

Note 4.6 for additional information regarding Genmab's share-based compensation programs and accounting policies.

**Remuneration to the Board of Directors**

---

| | | | | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
|  | **Base Board Fee** | **Base Board Fee** | **Base Board Fee** | **Committee Fees** | **Committee Fees** | **Committee Fees** | **Share-Based Compensation Expenses** | **Share-Based Compensation Expenses** | **Share-Based Compensation Expenses** | **Total** | **Total** | **Total** |
| **(DKK million)** | **2022** | **2021** | **2020** | **2022** | **2021** | **2020** | **2022** | **2021** | **2020** | **2022** | **2021** | **2020** |
| Deirdre P. Connelly | 1.2 | 1.2 | 1.1 | 0.5 | 0.5 | 0.5 | 0.9 | 0.7 | 0.7 | 2.6 | 2.4 | 2.3 |
| Pernille Erenbjerg | 0.9 | 0.9 | 0.7 | 0.4 | 0.4 | 0.4 | 0.7 | 0.5 | 0.4 | 2.0 | 1.8 | 1.5 |
| Anders Gersel Pedersen | 0.6 | 0.6 | 0.4 | 0.4 | 0.4 | 0.4 | 0.5 | 0.4 | 0.5 | 1.5 | 1.4 | 1.3 |
| Paolo Paoletti | 0.6 | 0.6 | 0.4 | 0.3 | 0.3 | 0.3 | 0.5 | 0.4 | 0.4 | 1.4 | 1.3 | 1.1 |
| Rolf Hoffmann | 0.6 | 0.6 | 0.4 | 0.3 | 0.4 | 0.3 | 0.5 | 0.4 | 0.5 | 1.4 | 1.4 | 1.2 |
| Elizabeth O'Farrell<sup>1</sup> | 0.5 | - | - | 0.2 | - | - | 0.6 | - | - | 1.3 | - | - |
| Jonathan Peacock<sup>2</sup> | - | 0.5 | 0.3 | - | 0.3 | 0.3 | - | 0.6 | 0.4 | - | 1.4 | 1.0 |
| Mats Pettersson<sup>3</sup> | - | - | 0.3 | - | - | 0.1 | - | - | 1.6 | - | - | 2.0 |
| Mijke Zachariasse<sup>4</sup> | 0.6 | 0.6 | 0.4 | - | - | - | 0.4 | 0.3 | 0.1 | 1.0 | 0.9 | 0.5 |
| Martin Schultz<sup>4</sup> | 0.5 | - | - | - | - | - | - | - | - | 0.5 | - | - |
| Takahiro Hamatani<sup>4</sup> | 0.5 | - | - | - | - | - | - | - | - | 0.5 | - | - |
| Peter Storm Kristensen<sup>5</sup> | 0.1 | 0.6 | 0.4 | - | - | - | 0.1 | 0.4 | 0.4 | 0.2 | 1.0 | 0.8 |
| Rima Bawarshi Nassar<sup>5,6</sup> | 0.1 | 0.6 | 0.1 | - | - | - | 0.1 | 0.2 | - | 0.2 | 0.8 | 0.1 |
| Daniel J. Bruno<sup>6</sup> | - | - | 0.3 | - | - | - | - | - | (0.4) | - | - | (0.1) |
| **Total**  | **6.2** | **6.2** | **4.8** | **2.1** | **2.3** | **2.3** | **4.3** | **3.9** | **4.6** | **12.6** | **12.4** | **11.7** |

---

1 – Elizabeth O'Farrell was newly elected to the Board of Directors at the Annual General Meeting in March 2022.

2 – Jonathan Peacock stepped down from the Board of Directors effective November 15, 2021, due to increased responsibilities in connection with his other board commitments.

3 – Mats Pettersson stepped down from the Board of Directors at the Annual General Meeting in March 2020.

4 – Employee elected board members were elected at the Annual General Meeting in March 2022.

5 – Peter Storm Kristensen and Rima Bawarshi Nassar stepped down from the Board of Directors as employee elected board members at the Annual General Meeting in March 2022.

6 – Daniel J. Bruno stepped down from the Board of Directors and Rima Bawarshi Nassar replaced Daniel J. Bruno on the Board of Directors as an employee elected board member during August 2020.

Refer to the section "Board of Directors" in Management's Review for additional information regarding the Board of Directors.

**Remuneration to the Executive Management**

---

| | | | | | | | | | | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
|  | **Base Salary** | **Base Salary** | **Base Salary** | **Defined Contribution Plans** | **Defined Contribution Plans** | **Defined Contribution Plans** | **Other Benefits** | **Other Benefits** | **Other Benefits** | **Annual Cash Bonus** | **Annual Cash Bonus** | **Annual Cash Bonus** | **Share-Based Compensation Expenses** | **Share-Based Compensation Expenses** | **Share-Based Compensation Expenses** | **Total** | **Total** | **Total** |
| **(DKK million)** | **2022** | **2021** | **2020** | **2022** | **2021** | **2020** | **2022** | **2021** | **2020** | **2022** | **2021** | **2020** | **2022** | **2021** | **2020** | **2022** | **2021** | **2020** |
| Jan van de Winkel | 8.6 | 7.9 | 7.3 | 1.3 | 1.1 | 1.0 | 0.3 | 0.6 | 1.0 | 8.6 | 7.9 | 8.4 | 22.9 | 20.6 | 19.6 | 41.7 | 38.1 | 37.3 |
| Anthony Pagano<sup>1</sup> | 4.3 | 3.2 | 3.0 | 0.1 | 0.1 | 0.1 | - | - | - | 2.6 | 1.9 | 2.3 | 9.5 | 7.2 | 5.2 | 16.5 | 12.4 | 10.6 |
| Anthony Mancini<sup>2</sup> | 4.7 | 3.9 | 3.1 | 0.1 | 0.1 | 0.1 | - | 3.1 | 3.3 | 2.8 | 2.3 | 2.0 | 11.4 | 7.2 | 3.1 | 19.0 | 16.6 | 11.6 |
| Judith Klimovsky | 4.9 | 4.0 | 4.0 | 0.1 | 0.1 | 0.1 | - | - | 0.1 | 2.9 | 2.5 | 3.0 | 14.1 | 13.2 | 12.7 | 22.0 | 19.8 | 19.9 |
| Tahamtan Ahmadi<sup>3</sup> | 4.6 | 3.3 | - | 0.1 | 0.1 | - | - | - | - | 2.8 | 2.0 | - | 7.7 | 5.5 | - | 15.2 | 10.9 | - |
| David A. Eatwell<sup>1</sup> | - | - | 0.9 | - | - | 0.1 | - | - | 2.5 | - | - | - | - | - | (2.3) | - | - | 1.2 |
| **Total**  | **27.1** | **22.3** | **18.3** | **1.7** | **1.5** | **1.4** | **0.3** | **3.7** | **6.9** | **19.7** | **16.6** | **15.7** | **65.6** | **53.7** | **38.3** | **114.4** | **97.8** | **80.6** |

---

1 – David A. Eatwell stepped down as CFO on February 29, 2020, and Anthony Pagano was appointed CFO and member of the Executive Management on March 1, 2020.

2 – Anthony Mancini was appointed Chief Operating Officer and member of the Executive Management in March 2020.

3 – Tahamtan Ahmadi was appointed Chief Medical Officer, Head of Experimental Medicines and member of the Executive Management in March 2021.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 122/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

Genmab has decided to implement an administrative organizational change whereby effective January 1, 2023, only Jan van de Winkel, President and Chief Executive Officer, and Anthony Pagano, Executive Vice President and Chief Financial Officer, will be formally registered as executive managers with the Danish Business Authority. Judith Klimovsky, Executive Vice President and Chief Development Officer, Anthony Mancini, Executive Vice President and Chief Operating Officer, and Tahamtan Ahmadi, Executive Vice President and Chief Medical Officer, will cease to be registered as executive managers with the Danish Business Authority; however, apart from the formal registration amendments there will be no changes to the Executive Management Team, including titles, areas of responsibility or otherwise.

Refer to the section "Senior Leadership" in Management's Review for additional information regarding the Executive Management.

**Severance Payments:**

In the event Genmab terminates the service agreements with any member of the Executive Management team without cause, Genmab is obliged to pay his/her existing salary for one or two years after the end of the one-year notice period. However, in the event of termination by Genmab (unless for cause) or by any member of Executive Management as a result of a change of control of Genmab, Genmab is obliged to pay compensation equal to his/her existing total salary (including benefits) for up to two years in addition to the notice period. In 2021, the Remuneration Policy was amended at the Annual General Meeting to specify that the total value of the remuneration relating to the notice period for new members of Executive Management cannot exceed two years of remuneration, including all components of the remuneration. In case of the termination of the service agreements of the Executive Management without cause, the total impact on our financial position is estimated to be approximately DKK 82 million as of December 31, 2022 (2021: DKK 72 million, 2020: DKK 52 million).

5.2 – Related Party Disclosures

Genmab's related parties are the parent company's subsidiaries, Board of Directors, Executive Management, and close members of the family of these persons.

Genmab has not granted any loans, guarantees or other commitments to or on behalf of any of the members of the Board of Directors or Executive Management.

Other than the remuneration and other transactions relating to the Board of Directors and Executive Management described in Note 5.1, there were no material related party transactions during 2022, 2021 and 2020.

5.3 – Commitments

#### PURCHASE OBLIGATIONS
Genmab has entered into a number of agreements related to research and development activities that contain various obligations. These short-term contractual obligations amounted to approximately DKK 1,687 million as of December 31, 2022, all of which is due in less than two years (2021: approximately DKK 1,340 million).

Genmab also has certain contingent commitments under license and collaboration agreements that may become due in the future. As of December 31, 2022, these contingent commitments amounted to approximately DKK 20,077 million (USD 2,880 million) in potential future development, regulatory and commercial milestone payments to third parties under license and collaboration agreements for our pre-clinical and clinical stage development programs as compared to approximately DKK 19,574 million (USD

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 123/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

2,983 million) as of December 31, 2021. These milestone payments generally become due and payable only upon the achievement of certain development, clinical, regulatory or commercial milestones. The events triggering such payments or obligations have not yet occurred.

In addition to the above obligations, Genmab enters into a variety of agreements and financial commitments in the normal course of business. The terms generally allow Genmab the option to cancel, reschedule and adjust our requirements based on our business needs prior to the delivery of goods or performance of services. It is not possible to predict the maximum potential amount of future payments under these agreements due to the conditional nature of our obligations and the unique facts and circumstances involved in each particular agreement.

5.4 – Fees to Auditors Appointed at the Annual General Meeting

---

| | | | |
|:---|:---|:---|:---|
| **(DKK million)** | **2022** | **2021** | **2020** |
| **PricewaterhouseCoopers** |  |  |  |
| Audit fees | 5.8 | 5.8 | 4.9 |
| Audit-related fees | 2.0 | 1.8 | 1.0 |
| Tax fees | - | - | 0.3 |
| All other fees | - | 0.1 | - |
| **Total**  | **7.8** | **7.7** | **6.2** |

---

Fees for other services than statutory audit of the financial statements provided by PricewaterhouseCoopers Statsautoriseret Revisionspartnerselskab amounted to DKK 2.0 million in 2022 (DKK 1.9 million and DKK 1.3 million in 2021 and 2020, respectively). These services primarily include agreed-upon procedures, other assurance assessments and reports, accounting advice, educational training and tax and VAT compliance.

5.5 – Adjustments to Cash Flow Statements

---

| | | | | |
|:---|:---|:---|:---|:---|
| **(DKK million)** | **Note** | **2022** | **2021** | **2020** |
| **Adjustments for non-cash transactions:** |  |  |  |  |
| Depreciation, amortization and impairment | 3.1, 3.2, 3.3 | 362 | 248 | 259 |
| Share-based compensation expenses | 2.3, 4.6 | 439 | 310 | 200 |
| Other |  | - | (32) | - |
| **Total adjustments for non-cash transactions** |  | **801** | **526** | **459** |
| **Change in operating assets and liabilities:** |  |  |  |  |
| Receivables |  | (2213) | (1074) | 306 |
| Deferred revenue |  | - | - | 513 |
| Other payables  |  | 283 | 304 | 168 |
| **Total change in operating assets and liabilities** |  | **(1930)** | **(770)** | **987** |

---

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|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 124/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

5.6 – Collaborations and Technology Licenses

#### Collaborations
Genmab enters into collaborations with biotechnology and pharmaceutical companies to advance the development and commercialization of Genmab's product candidates and to supplement its internal pipeline. Genmab seeks collaborations that will allow Genmab to retain significant future participation in product sales through either profit-sharing or royalties paid on net sales. Below is an overview of certain of Genmab's collaborations that have had, or are expected in the near term to have, a significant impact on financial results.

#### Janssen (Daratumumab/DARZALEX)
In 2012, Genmab entered into a global license, development and commercialization agreement with Janssen for daratumumab (marketed for the treatment of certain multiple myeloma indications as DARZALEX for IV administration and as DARZALEX *FASPRO* in the U.S. and DARZALEX SC in Europe for SC administration). Under this agreement, Janssen is fully responsible for developing and commercializing daratumumab, and all costs associated therewith. Genmab receives tiered royalty payments between 12% and 20% based on Janssen's annual net product sales. The royalties payable by Janssen are limited in time and subject to reduction on a country-by-country basis for customary reduction events, including upon patent expiration or invalidation in the relevant country and upon the first commercial sale of a biosimilar product in the relevant country (for as long as the biosimilar product remains for sale in that country). Pursuant to the terms of the agreement, Janssen's obligation to pay royalties under this agreement will expire on a country-by-country basis on the later of the date that is 13 years after the first commercial sale of daratumumab in such country or upon the expiration of the last-to-expire relevant Genmab-owned patent (as defined in the agreement) covering daratumumab in such country. Genmab is also eligible to receive certain additional payments in connection with development, regulatory and sales milestones.

In September 2020, Genmab commenced binding arbitration of two matters arising under its license agreement with Janssen relating to daratumumab. Under the license agreement, Genmab is, among other things, entitled to royalties from Janssen on net sales of daratumumab (marketed as DARZALEX for IV administration and as DARZALEX *FASPRO* in the U.S. and as DARZALEX SC in Europe for SC administration). In April 2022, the arbitral tribunal issued an award in the binding arbitration of the two matters. Genmab did not seek a review of the award, and the award is now final.

The first matter concerned the question as to whether Janssen's obligation to pay royalties on sales of licensed product extends, in each applicable country, until the expiration or invalidation of the last-to-expire relevant Genmab-owned patent or the last-to-expire relevant Janssen-owned patent covering the product, as further defined and described in the license agreement. As to that matter, the tribunal determined by majority opinion that Janssen's obligation to pay royalties to Genmab on sales of licensed product, in each applicable country, extends through the expiration or invalidation of the last-to-expire relevant Genmab-owned patent covering the product or use thereof, but not the relevant Janssen-owned patent. The relevant Genmab-owned issued U.S., European and Japanese patents will expire in the late 2020s and early 2030s.

The second matter concerned the question as to whether Genmab is required to share in Janssen's royalty payments to Halozyme for the Halozyme enzyme technology used in the SC formulation of daratumumab (marketed as DARZALEX *FASPRO* in the U.S.). The royalties Janssen pays to Halozyme represent a mid-single digit percentage rate of SC daratumumab sales. As to that matter, the tribunal ruled by majority opinion that Janssen is permitted to continue reducing its royalty payments to Genmab as an offset against a share of Janssen's royalty payments made to Halozyme.

On June 9, 2022, Genmab announced the commencement of a second arbitration under the daratumumab license agreement with Janssen. This second arbitration follows from the award in the prior arbitration, where

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|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 125/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

the tribunal ruled in favor of Janssen on the question as to whether Genmab is required to share in Janssen's royalty payments to Halozyme for its technology used in the daratumumab SC product. The tribunal based its ruling on the finding that DARZALEX *FASPRO* constitutes a new licensed product under the license agreement.

In this second arbitration, Genmab is consequently seeking an award of USD 405 million plus interest in accrued milestone payments for DARZALEX *FASPRO* and a declaration that it is entitled to a new 13-year royalty term from the date of DARZALEX *FASPRO*'s first commercial sale. See Company Announcement no. 21/2022.

#### Novartis (Ofatumumab/Kesimpta)
Genmab and GlaxoSmithKline (GSK) entered a co-development and collaboration agreement for ofatumumab in 2006. The full rights to ofatumumab were transferred from GSK to Novartis in 2015. Novartis is now fully responsible for the development and commercialization of ofatumumab in all potential indications, including autoimmune diseases. Genmab is entitled to a 10% royalty payment of net sales for non-cancer treatments. Novartis's obligation to pay royalties under this agreement expire on a country-by-country basis only in the event Novartis is no longer selling such product is a given country. In 2020 SC ofatumumab was approved by the U.S. FDA, as Kesimpta, for the treatment of RMS in adults.

Ofatumumab was also previously approved as Arzerra<sup>®</sup> for certain CLL indications. In 2019, the marketing authorization for Arzerra was withdrawn in the EU and several other territories. In August 2020, Genmab announced that Novartis planned to transition Arzerra to an oncology access program for CLL patients in the U.S. In 2020, Genmab recognized USD 30 million lump sum from Novartis as payment for lost potential royalties. Ofatumumab is no longer in development for CLL.

#### Roche (Teprotumumab/TEPEZZA)
In May 2001, Genmab entered a collaboration with Roche to develop human antibodies to disease targets identified by Roche. In 2002, this alliance was expanded, and Roche made an equity investment in Genmab. Under the agreement, Genmab will receive milestones as well as royalty payments on successful products and, in certain circumstances, Genmab could obtain rights to develop products based on disease targets identified by Roche.

#### Seagen (Tisotumab vedotin/Tivdak)
In September 2010, Genmab and Seagen entered into an ADC collaboration, and a commercial license and collaboration agreement was executed in October 2011. Under the agreement, Genmab was granted rights to utilize Seagen's ADC technology with its human monoclonal TF antibody. Seagen was granted rights to exercise a co-development and co-commercialization option at the end of Phase 1 clinical development for tisotumab vedotin. In August 2017, Seagen exercised this option. In October 2020, Genmab and Seagen entered into a joint commercialization agreement. Genmab is co-promoting tisotumab vedotin in the U.S. and will lead commercial operational activities and book sales in Japan, while Seagen will lead operational commercial activities in the U.S., Europe and China with a 50:50 cost and profit split in those markets. In any other markets, Seagen will be responsible for commercializing tisotumab vedotin and Genmab will receive royalties based on a percentage of aggregate net sales ranging from the mid-teens to the mid-twenties. The companies will continue the practice of joint decision-making on the worldwide development and commercialization strategy for tisotumab vedotin.

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| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 126/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

In September 2021, tisotumab vedotin was approved by the U.S. FDA and is marketed under the trade name Tivdak. Seagen records product sales of Tivdak in the U.S. and Genmab shares 50% of the profits for this product.

#### AbbVie (Epcoritamab)
On June 10, 2020, Genmab entered into a broad oncology collaboration agreement with AbbVie to jointly develop and commercialize epcoritamab, DuoHexaBody-CD37 and DuoBody-CD3x5T4, and a discovery research collaboration for future differentiated antibody therapeutics for cancer. For epcoritamab, the companies will share commercial responsibilities in the U.S. and Japan, with AbbVie responsible for further global commercialization. Genmab will book sales in the U.S. and Japan and receive tiered royalties on remaining global sales outside of these territories. For any product candidates developed as a result of the companies' discovery research collaboration, Genmab and AbbVie will share responsibilities for global development and commercialization in the U.S. and Japan. Genmab retains the right to co-commercialize these products, along with AbbVie, outside of the U.S. and Japan.

Under the terms of the agreement, Genmab received a USD 750 million (DKK 4,911 million) upfront payment in June 2020 and was initially entitled to receive an aggregate of up to USD 3.15 billion in additional development, regulatory and sales milestone payments for all programs. Included in these potential milestones were up to USD 1.15 billion in payments related to clinical development and commercial success across the three bispecific antibody programs originally included in the agreement, one of which, DuoBody-CD3x5T4, was subsequently stopped and another, DuoHexaBody-CD37, now being solely developed by Genmab.

As a result of one program being stopped and another now being solely developed by Genmab, Genmab is instead contractually entitled to receive an aggregate of up to USD 2.55 billion in additional development, regulatory and sales milestone payments for all programs and up to USD 550 million in payments related to clinical development and commercial success for the one remaining bispecific antibody program, epcoritamab, included in the original agreement. In addition, and also included in these potential milestones, if all four next-generation antibody product candidates developed as a result of the discovery research collaboration are successful, Genmab is eligible to receive up to USD 2.0 billion in option exercise and success-based milestones. Genmab is further entitled to tiered royalties between 22% and 26% on net sales for epcoritamab outside the United States and Japan. Except for these royalty-bearing sales, Genmab will share with AbbVie pre-tax profits from the sale of licensed products on a 50:50 basis. Genmab and AbbVie split 50:50 the development costs related to epcoritamab, while Genmab will be responsible for 100% of the costs for DuoHexaBody-CD37 (after December 24, 2022) and the discovery research programs up to opt-in.

The total transaction price of USD 750 million (DKK 4,911 million) was allocated to the four performance obligations based on the best estimate of relative stand-alone selling prices. The allocation of the transaction price to the performance obligations is summarized below:

• Delivery of licenses for the three programs: USD 672 million (DKK 4,398 million)

• Co-development activities for the product concepts: USD 78 million (DKK 513 million)

For the license grants, Genmab based the stand-alone selling price on a discounted cash flow approach and considered several factors including, but not limited to, discount rate, development timeline, regulatory risks, estimated market demand and future revenue potential. For co-development activities related to up to four product concepts, a cost-plus margin approach was utilized.

The performance obligations related to the delivery of licenses were completed at a point in time (June 2020) and Genmab recognized USD 672 million (DKK 4,398 million) as license fee revenue in June 2020. After delivery of the licenses, Genmab shares further development and commercial costs equally with AbbVie.

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|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 127/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

AbbVie is not assessed as a customer but as a collaboration partner, and as such this part of the collaboration is not in scope of IFRS 15.

In September 2021, Genmab, along with AbbVie, decided that the data did not support the further development of DuoBody-CD3x5T4. In June 2022, AbbVie decided to discontinue co-development of DuoHexaBody-CD37. Upon expiry of the 180-day notice period on December 24, 2022, Genmab became solely responsible for the further development of DuoHexaBody-CD37 against low-single digit royalty payments to AbbVie, up to an agreed maximum total royalty amount, based on future potential sales of the product.

Refer to Note 3.6 for information pertaining to the remaining performance obligation related to co-development activities for the product concepts.

#### BioNTech
In May 2015, Genmab entered into an agreement with BioNTech to jointly research, develop and commercialize bispecific antibody products using Genmab's DuoBody technology platform. Under the terms of the agreement, BioNTech will provide proprietary antibodies against key immunomodulatory targets, while Genmab provides proprietary antibodies and access to its DuoBody technology platform. Genmab paid an upfront fee of USD 10 million to BioNTech and an additional fee as certain BioNTech assets were selected for further development. If the companies jointly select any product candidates for clinical development, development costs and product ownership will be shared equally going forward. If one of the companies does not wish to move a product candidate forward, the other company is entitled to continue developing the product on predetermined licensing terms. The agreement also includes provisions which will allow the parties to opt out of joint development at key points. During July 2022, Genmab and BioNTech expanded this collaboration to include the joint research, development and commercialization of monospecific antibody candidates using Genmab's HexaBody technology platform.

Genmab and BioNTech have four investigational medicines currently in clinical development: DuoBody-CD40x4-1BB (GEN1042/BNT312), DuoBody-PD-L1x4-1BB (GEN1046/BNT311), HexaBody-CD27 (GEN1053/BNT313) and GEN1056 (BNT322).

#### Janssen (DuoBody)
In July 2012, Genmab entered into a collaboration with Janssen to create and develop bispecific antibodies using our DuoBody technology platform. Under this original agreement, Janssen had the right to use the DuoBody technology platform to create panels of bispecific antibodies (up to 10 DuoBody programs) to multiple disease target combinations. Genmab received an upfront payment of USD 3.5 million from Janssen and will potentially be entitled to milestone and license payments of up to approximately USD 175 million, as well as royalties for each commercialized DuoBody product.

Under the terms of a December 2013 amendment, Janssen was entitled to work on up to 10 additional programs. Genmab received an initial payment of USD 2 million from Janssen. For each of the additional programs that Janssen successfully initiates, develops and commercializes, Genmab will potentially be entitled to receive average milestone and license payments of approximately USD 191 million. Genmab will be entitled to royalties on sales of any commercialized products. All research work is funded by Janssen.

Janssen has exercised 14 licenses under this collaboration, not all of which are active, and no further options remain for use by Janssen.

As of December 31, 2022, three DuoBody-based products created under this collaboration were in active clinical development. Of these, RYBREVANT and TECVAYLI were the first and second medicines, respectively, created using the DuoBody technology platform to receive regulatory approval. In December

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|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 128/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

2022, Janssen submitted a BLA to the U.S. FDA for the third product in active clinical development, talquetamab, for the treatment of patients with relapsed or refractory multiple myeloma. Genmab receives milestones and royalties between 8% and 10% for RYBREVANT and milestones and a mid-single digit royalty for TECVAYLI based on Janssen's annual net product sales. Pursuant to the terms of the DuoBody agreement, Janssen's obligation to pay these royalties will expire on a country-by-country and licensed product-by-licensed product basis on the later of the date that is 10 years after the first sale of each licensed product in such country or upon the expiration of the last-to-expire relevant product patent (as defined in the agreement) covering the licensed product in such country.

5.7 – Subsequent Events

No events have occurred subsequent to the balance sheet date that could significantly affect the financial statements as of December 31, 2022.

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|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 129/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### **Table of Contents**

---

| | |
|:---|:---|
| [**FINANCIAL STATEMENTS OF THE PARENT COMPANY**](#_Financial_Statements_of_2) | [131](#_Financial_Statements_of) |
| &nbsp;&nbsp;&nbsp;&nbsp;[Income Statements](#ISStatementsofComprehensiveIncome_908263) | 131 |
| &nbsp;&nbsp;&nbsp;&nbsp;[Balance Sheets](#BSBalanceSheets_627835) | 132 |
| &nbsp;&nbsp;&nbsp;&nbsp;[Statements of Cash Flows](#StatementsofCashFlows_793461) | 133 |
| &nbsp;&nbsp;&nbsp;&nbsp;[Statements of Changes in Equity](#_Statements_of_Changes_2) | 134 |
| **NOTES** |  |
| &nbsp;&nbsp;&nbsp;&nbsp;[1 Accounting Policies](#a1AccountingPolicies_574419) | 135 |
| &nbsp;&nbsp;&nbsp;&nbsp;[2 Revenue](#a2Revenue_510501) | 137 |
| &nbsp;&nbsp;&nbsp;&nbsp;[3 Staff Costs](#a3StaffCosts_434389) | 138 |
| &nbsp;&nbsp;&nbsp;&nbsp;[4 Corporate and Deferred Tax](#a4CorporateandDeferredTax_450765) | 139 |
| &nbsp;&nbsp;&nbsp;&nbsp;[5 Intangible Assets](#a5IntangibleAssets_848871) | 141 |
| &nbsp;&nbsp;&nbsp;&nbsp;[6 Property and Equipment](#a6PropertyPlantandEquipment_780698) | 142 |
| &nbsp;&nbsp;&nbsp;&nbsp;[7 Leases](#a7Leases_357928) | 142 |
| &nbsp;&nbsp;&nbsp;&nbsp;[8 Other Investments](#a8OtherInvestments_992708) | 144 |
| &nbsp;&nbsp;&nbsp;&nbsp;[9 Receivables](#a9Receivables_975346) | 144 |
| &nbsp;&nbsp;&nbsp;&nbsp;[10 Deferred Revenue](#a10DeferredRevenue) | 144 |
| &nbsp;&nbsp;&nbsp;&nbsp;[11 Other Payables](#a10OtherPayables_73879) | 145 |
| &nbsp;&nbsp;&nbsp;&nbsp;[12 Marketable Securities](#a11MarketableSecurities_506447) | 145 |
| &nbsp;&nbsp;&nbsp;&nbsp;[13 Financial Income and Expenses](#a12FinancialIncomeandExpenses_934862) | 145 |
| &nbsp;&nbsp;&nbsp;&nbsp;[14 Remuneration of the Board of Directors and Executive Management](#a13RemunerationoftheBoardofDirectors_978) | 146 |
| &nbsp;&nbsp;&nbsp;&nbsp;[15 Related Party Disclosures](#a14RelatedPartyDisclosures_381178) | 146 |
| &nbsp;&nbsp;&nbsp;&nbsp;[16 Investments in Subsidiaries](#a15InvestmentsinSubsidiaries_814225) | 147 |
| &nbsp;&nbsp;&nbsp;&nbsp;[17 Commitments](#a16Commitments_407843) | 147 |
| &nbsp;&nbsp;&nbsp;&nbsp;[18 Fees to Auditors Appointed at the Annual General Meeting](#a17FeestoAuditorsAppointedatthe_691505) | 148 |
| &nbsp;&nbsp;&nbsp;&nbsp;[19 Adjustments to Cash Flow Statements](#a18AdjustmentstoCashFlowStatement_11722) | 149 |

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|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 130/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

### Financial Statements of the Parent Company

#### Income Statements

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | Note | 2022 | 2021 | 2020 |
| (DKK million) |  |  | Restated\* | Restated\* |
| **Revenue (restated\*)** | 2 | **14827** | **8606** | **10026** |
| Research and development expenses (restated\*) | 3, 5, 6 | (6277) | (3870) | (2960) |
| Selling, general and administrative expenses (restated\*) | 3, 6 | (2728) | (1219) | (599) |
| **Operating expenses (restated\*)** |  | **(9005)** | **(5089)** | **(3559)** |
| **Operating profit (restated\*)** |  | **5822** | **3517** | **6467** |
| Financial income | 13 | 1300 | 1610  | 254  |
| Financial expenses | 13 | (369) | (254) | (1519) |
| **Net profit before tax (restated\*)** |  | **6753** | **4873** | **5202** |
| Corporate tax | 4 | (1511) | (975) | (1077) |
| **Net profit (restated\*)** |  | **5242** | **3898** | **4125** |
| \* See Note 1 for details regarding the restatement as a result of errors and change in accounting policies. |  |  |  |  |

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|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 131/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### Balance Sheets

---

| | | | | |
|:---|:---|:---|:---|:---|
|  |  | December 31, | December 31, | January 1, |
| (DKK million) | Note | 2022 | 2021 | 2021 |
|  |  |  | Restated\* | Restated\* |
| **ASSETS** |  |  |  |  |
| Intangible assets | 5 | 357 | 236 | 304 |
| Property and equipment | 6 | 26 | 13 | 10 |
| Right-of-use assets | 7 | 9 | 12 | 24 |
| Investments in subsidiaries (restated\*) | 16 | 2806 | 2506 | 1954 |
| Receivables | 9 | 35 | 8 | 6 |
| Deferred tax assets | 4 | 243 | 252 | 177 |
| Other investments | 8 | 66 | 27 | 14 |
| **Total non-current assets (restated\*)** |  | **3542** | **3054** | **2489** |
| Corporate tax receivable | 4 | 150 | 39 | 250 |
| Receivables | 9 | 5756 | 3187 | 2379 |
| Receivables from subsidiaries (restated\*) | 9 | 129 | 9 | 73 |
| Marketable securities | 12 | 12431 | 10381 | 8819 |
| Cash and cash equivalents |  | 8830 | 8783 | 7133 |
| **Total current assets (restated\*)** |  | **27296** | **22399** | **18654** |
| **Total assets (restated\*)** |  | **30838** | **25453** | **21143** |
| **SHAREHOLDERS' EQUITY AND LIABILITIES** |  |  |  |  |
| Share capital |  | 66 | 66 | 66 |
| Share premium |  | 12309 | 12029 | 11894 |
| Retained earnings (restated\*) |  | 15900 | 11226 | 7423 |
| **Total shareholders' equity (restated\*)** |  | **28275** | **23321** | **19383** |
| Lease liabilities | 7 | - | - | 11 |
| Deferred revenue | 10 | 480 | 487 | 487 |
| Other payables | 11 | - | 6 | 5 |
| **Total non-current liabilities** |  | **480** | **493** | **503** |
| Payable to subsidiaries | 11 | 1136 | 770 | 358 |
| Lease liabilities | 7 | 5 | 11 | 12 |
| Deferred revenue | 10 | 33 | 26 | 26 |
| Other payables | 11 | 909 | 832 | 861 |
| **Total current liabilities** |  | **2083** | **1639** | **1257** |
| **Total liabilities** |  | **2563** | **2132** | **1760** |
| **Total shareholders' equity and liabilities (restated\*)** |  | **30838** | **25453** | **21143** |
| \* See Note 1 for details regarding the restatement as a result of errors and change in accounting policies. |  |  |  |  |

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|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 132/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

**Statements of Cash Flows**

---

| | | | | |
|:---|:---|:---|:---|:---|
| (DKK million) | Note | 2022 | 2021 | 2020 |
|  |  |  | Restated\* | Restated\* |
| **Cash flows from operating activities:** |  |  |  |  |
| **Net profit before tax (restated\*)** |  | **6753** | **4873** | **5202** |
| Reversal of financial items, net | 13 | (931) | (1356) | 1265 |
| Adjustment for non-cash transactions (restated\*) | 19 | 172 | 139 | 177  |
| Change in operating assets and liabilities (restated\*) | 19 | (2186) | (954) | 1039  |
| **Cash provided by operating activities before financial items (restated\*)** |  | **3808** | **2702** | **7683** |
| Interest received |  | 280 | 207 | 170  |
| Interest elements of lease payments | 7 | - | - | (1) |
| Interest paid  |  | (1) | - | (11) |
| Corporate taxes (paid)/received |  | (1583) | (739) | (1476) |
| **Net cash provided by operating activities (restated\*)** |  | **2504** | **2170** | **6365** |
| **Cash flows from investing activities:** |  |  |  |  |
| Investment in intangible assets | 5 | (191) | - | - |
| Investment in tangible assets | 6 | (21) | (7) | (3) |
| Transactions with subsidiaries (restated\*) |  | 374 | 93 | (117) |
| Marketable securities bought |  | (9659) | (15514) | (12414) |
| Marketable securities sold |  | 7254 | 14469 | 10370  |
| Other investments bought |  | (39) | (18) | - |
| **Net cash (used in) investing activities (restated\*)** |  | **(2282)** | **(977)** | **(2164)** |
| **Cash flows from financing activities:** |  |  |  |  |
| Warrants exercised |  | 280 | 135 | 140  |
| Principal elements of lease payments | 7 | (13) | (13) | (12) |
| Purchase of treasury shares |  | (908) | (447) | - |
| Payment of withholding taxes on behalf of employees on net settled RSUs |  | (88) | (50) | (25) |
| **Net cash provided by (used in) financing activities** |  | **(729)** | **(375)** | **103** |
| **Changes in cash and cash equivalents** |  | **(507)** | **818** | **4304** |
| Cash and cash equivalents at the beginning of the period |  | 8783 | 7133 | 3274  |
| Exchange rate adjustments |  | 554 | 832 | (445) |
| **Cash and cash equivalents at the end of the period** |  | **8830** | **8783** | **7133** |
| **Cash and cash equivalents include:** |  |  |  |  |
| Bank deposits |  | 8236 | 8487 | 4927 |
| Short-term marketable securities |  | 594 | 296 | 2206 |
| **Cash and cash equivalents at the end of the period** |  | **8830** | **8783** | **7133** |
| \* See Note 1 for details regarding the restatement as a result of errors and change in accounting policies. |  |  |  |  |

---

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 133/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### Statements of Changes in Equity

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
|  | Share capital | Share premium | Translation Reserves | Retained earnings | Shareholders' equity |
| (DKK million) |  |  |  |  |  |
| **Balance at December 31, 2019** | **65** | **11755** | **98** | **2130** | **14048** |
| Change in accounting policy | - | - | (98) | 949 | 851 |
| **Balance at December 31, 2019 (restated\*)** | **65** | **11755** | **-** | **3079** | **14899** |
| Net profit (restated\*) | - | - | - | 4125 | 4125 |
| Exercise of warrants | 1 | 139 | - | - | 140 |
| Share-based compensation expenses | - | - | - | 200 | 200 |
| Net settlement of RSUs | - | - | - | (25) | (25) |
| Tax on items recognized directly in equity | - | - | - | 44 | 44 |
| **Balance at December 31, 2020 (restated\*)** | **66** | **11894** | **-** | **7423** | **19383** |
| Net profit (restated\*) | - | - | - | 3898 | 3898 |
| Exercise of warrants | - | 135 | - | - | 135 |
| Purchase of treasury shares | - | - | - | (447) | (447) |
| Share-based compensation expenses | - | - | - | 310 | 310 |
| Net settlement of RSUs | - | - | - | (50) | (50) |
| Tax on items recognized directly in equity | - | - | - | 92 | 92 |
| **Balance at December 31, 2021 (restated\*)** | **66** | **12029** | **-** | **11226** | **23321** |
| Net profit | - | - | - | 5242 | 5242 |
| Exercise of warrants | - | 280 | - | - | 280 |
| Purchase of treasury shares | - | - | - | (908) | (908) |
| Share-based compensation expenses | - | - | - | 439 | 439 |
| Net settlement of RSUs | - | - | - | (88) | (88) |
| Tax on items recognized directly in equity | - | - | - | (11) | (11) |
| **Balance at December 31, 2022** | **66** | **12309** | **-** | **15900** | **28275** |
| \* See Note 1 for details regarding the restatement as a result of errors and change in accounting policies. |  |  |  |  |  |

---

#### DISTRIBUTION OF THE YEAR'S Profit
The Board of Directors proposes that the parent company's 2022 net profit of DKK 5,242 million (2021: restated net profit of DKK 3,898 million and 2020: restated net profit of DKK 4,125 million) be carried forward to next year by transfer to retained earnings.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 134/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### 1 – Accounting Policies
The financial statements of the parent company have been prepared in accordance with the International Financial Reporting Standards (IFRS) as issued by the International Accounting Standards Board (IASB) and in accordance with IFRS as endorsed by the EU and further requirements in the Danish Financial Statements Act (Class D).

A number of new or amended standards became applicable for the current reporting period. Genmab A/S did not have to change its accounting policies as a result of the adoption of these standards.

Refer to Note 1.2 in the consolidated financial statements for a description of new accounting policies and disclosures of the Group.

#### Changes to Accounting Policies
**Investments in Subsidiaries**

IFRS standard IAS 27 "Separate Financial Statements" permits investments in subsidiaries to be accounted for either at cost, at fair value in accordance with IFRS 9 "Financial Instruments" or using the equity method as described in IAS 28 "Investments in Associates and Joint Ventures". Effective January 1, 2022, Genmab A/S has elected to measure investments in subsidiaries at cost in the financial statements of the parent company. Previously, investments in subsidiaries were measured using the equity method. This election was made as Genmab A/S has determined that measurement at cost provides more relevant information about the conditions of the parent company financial statements.

Under the cost method, investments in subsidiaries are measured at historical cost. Equity interests in foreign currencies are translated to the reporting currency by use of historical exchange rates prevailing at the time of investment.

Additions to the carrying value of investment in subsidiaries include capital contributions made by the parent and share-based payment transactions related to employees of the respective subsidiaries based on where the employee has rendered service.

Distributions from the investment are recognized as income when declared, if any. If the distribution exceeds the current period income or if circumstances or changes in Genmab's operations indicate that the carrying amount of the subsidiary may not be recoverable, the carrying amount is tested for impairment. Where the recoverable amount of the investments is lower than cost, the investments are written down to this lower value.

**Correction of Prior Period Errors**

During the period ending December 31, 2022, the parent company revised its income statements and statements of cash flows to correct an error related to share-based compensation expenses recorded by the parent company that should have been reported by its subsidiaries. Under IFRS 2, share-based payment transactions among group entities should be recorded as an expense by the entity that is receiving goods or services. The error resulted in an overstatement of Genmab A/S' share-based compensation expenses and an understatement of (loss) in subsidiaries, net of tax in the prior financial years.

In addition, an error was discovered related to cost sharing reimbursements with subsidiaries that were incorrectly recorded as a reduction to revenue. The error resulted in an understatement of revenue and research and development expenses, resulting in a revision in the parent company's income statements.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 135/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

The impact of the change in accounting policy and the correction of the prior period errors on the financial statements are shown below. The comparative figures for fiscal years 2021 and 2020 have been restated accordingly.

---

| | | | | | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
|  | 2022 | 2022 | 2022 | 2021 | 2021 | 2021 | 2021 | 2021 | 2020 | 2020 | 2020 | 2020 | 2020 |
| (DKK million) | Reported Balances | Effect of Change in Accounting Policies | Balances Before Change in Accounting Policies | Restated Balances | Effect of Change in Accounting Policies | Effect of Error Correction - Share-Based Compensation Expense | Effect of Error Correction - Revenue | Previously Reported Balances | Restated Balances | Effect of Change in Accounting Policies | Effect of Error Correction - Share-Based Compensation Expense | Effect of Error Correction - Revenue | Previously Reported Balances |
| **Income Statements:** |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Revenue | 14827 | - | 14827 | 8606 | - | - | 97 | 8509 | 10026 | - | - | 41 | 9985 |
| Research and development expenses | (6277) | - | (6277) | (3870) | - | 184 | (97) | (3957) | (2960) | - | 122 | (41) | (3041) |
| Selling, general and administrative expenses | (2728) | - | (2728) | (1219) | - | 77 | - | (1296) | (599) | - | 38 | - | (637) |
| **Operating expenses** | **(9005)** | **-** | **(9005)** | **(5089)** | **-** | **261** | **(97)** | **(5253)** | **(3559)** | **-** | **160** | **(41)** | **(3678)** |
| **Operating profit** | **5822** | **-** | **5822** | **3517** | **-** | **261** | **-** | **3256** | **6467** | **-** | **160** | **-** | **6307** |
| Profit / (Loss) in subsidiaries, net of tax | - | (566) | 566 | - | 890 | (261) | - | (629) | - | (633) | (160) | - | 793 |
| **Net profit before tax** | **6753** | **(566)** | **7319** | **4873** | **890** | **-** | **-** | **3983** | **5202** | **(633)** | **-** | **-** | **5835** |
| **Net profit** | **5242** | **(566)** | **5808** | **3898** | **890** | **-** | **-** | **3008** | **4125** | **(633)** | **-** | **-** | **4758** |
| Adjustment of foreign currency fluctuations on subsidiaries | - | (41) | 41 | - | (27) | - | - | 27 | - | 44 | - | - | (44) |
| **Balance Sheets:** |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Investments in subsidiaries | 2806 | 891 | 1915 | 2506 | 1195 | - | - | 1311 | 1954 | 332 | - | - | 1622 |
| **Total non-current assets** | **3542** | **891** | **2651** | **3054** | **1195** | **-** | **-** | **1859** | **2489** | **332** | **-** | **-** | **2157** |
| Receivables from subsidiaries | 129 | - | 129 | 9 | (70) | - | - | 79 | 73 | (70) | - | - | 143 |
| **Total current assets** | **27296** | **-** | **27296** | **22399** | **(70)** | **-** | **-** | **22469** | **18654** | **(70)** | **-** | **-** | **18724** |
| **Total assets** | **30838** | **891** | **29947** | **25453** | **1125** | **-** | **-** | **24328** | **21143** | **262** | **-** | **-** | **20881** |
| Other reserves | - | (122) | 122 | - | (81) | - | - | 81 | - | (54) | - | - | 54 |
| Retained earnings | 15900 | 1013 | 14887 | 11226 | 1206 | - | - | 10020 | 7423 | 316 | - | - | 7107 |
| **Total shareholders' equity** | **28275** | **891** | **27384** | **23321** | **1125** | **-** | **-** | **22196** | **19383** | **262** | **-** | **-** | **19121** |
| **Total shareholders' equity and liabilities** | **30838** | **891** | **29947** | **25453** | **1125** | **-** | **-** | **24328** | **21143** | **262** | **-** | **-** | **20881** |
| **Statements of Cash Flows:** |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Net profit before tax | 6753 | (566) | 7319 | 4873 | 890 | - | - | 3983 | 5202 | (633) | - | - | 5835 |
| Reversal of profit/(loss) in subsidiaries, net of tax | - | 566 | (566) | - | (890) | 261 | - | 629 | - | 633 | 160 | - | (793) |
| Adjustment for non-cash transactions | 172 | - | 172 | 139 | - | (261) | - | 400 | 177 | - | (160) | - | 337 |
| Change in operating assets and liabilities | (2186) | - | (2186) | (954) | 70 | - | - | (1024) | 1039 | 70 | - | - | 969 |
| **Cash provided by operating activities before financial items** | **3808** | **-** | **3808** | **2702** | **70** | **-** | **-** | **2632** | **7683** | **70** | **-** | **-** | **7613** |
| **Net cash provided by operating activities** | **2504** | **-** | **2504** | **2170** | **70** | **-** | **-** | **2100** | **6365** | **70** | **-** | **-** | **6295** |
| Transactions with subsidiaries | 374 | - | 374 | 93 | (70) | - | - | 163 | (117) | (70) | - | - | (47) |
| **Net cash (used in) investing activities** | **(2282)** | **-** | **(2282)** | **(977)** | **(70)** | **-** | **-** | **(907)** | **(2164)** | **(70)** | **-** | **-** | **(2094)** |

---

#### Supplementary Accounting Policies for the Parent Company

#### Investments in Subsidiaries
The cost method is used for measuring the investments in subsidiaries. Under the cost method, investments in subsidiaries are measured at historical cost. Equity interests in foreign currencies are translated to the reporting currency by use of historical exchange rates prevailing at the time of investment.

Additions to the carrying value of investment in subsidiaries include capital contributions made by the parent and share-based payment transactions related to employees of the respective subsidiaries based on where the employee has rendered service.

Distributions from the investment are recognized as income when declared, if any. If the distribution exceeds the current period income or if circumstances or changes in Genmab's operations indicate that the carrying amount of the subsidiary may not be recoverable, the carrying amount is tested for impairment. Where the recoverable amount of the investments is lower than cost, the investments are written down to this lower value.

Refer to Note 1.1 in the consolidated financial statements for a description of the accounting policies of the Group.

Refer to Note 1.3 in the consolidated financial statements for a description of management's judgements and estimates under IFRS.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 136/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### 2 – Revenue

---

| | | | |
|:---|:---|:---|:---|
| **(DKK million)** | **2022** | **2021** | **2020** |
| **Revenue by type:** |  |  |  |
| Royalties  | 11672 | 6977 | 4741 |
| Reimbursement revenue | 1050 | 655 | 517 |
| Milestone revenue | 1767 | 954 | 351 |
| License revenue | 6 | - | 4417 |
| Collaboration revenue | 332 | 20 | - |
| **Total**  | **14827** | **8606** | **10026** |
| **Revenue by collaboration partner:** |  |  |  |
| Janssen | 10620 | 6847 | 4693 |
| AbbVie | 1174 | 245 | 4227 |
| Roche | 796 | 603 | 305 |
| Novartis | 815 | 236 | 212 |
| BioNTech | 708 | 416 | 230 |
| Seagen | 413 | 135 | 201 |
| Other | 301 | 124 | 158 |
| **Total**  | **14827** | **8606** | **10026** |
| **Royalties by product:** |  |  |  |
| DARZALEX | 10056 | 6135 | 4419 |
| TEPEZZA | 796 | 593 | 298 |
| Kesimpta | 779 | 235 | 10 |
| Other | 41 | 14 | 14 |
| **Total**  | **11672** | **6977** | **4741** |

---

Refer to Note 2.1 in the consolidated financial statements for additional information regarding revenue of the Group.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 137/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### 3 – Staff Costs

---

| | | | |
|:---|:---|:---|:---|
| **(DKK million)** | **2022** | **2021** | **2020** |
| Wages and salaries | 392 | 277 | 182 |
| Share-based compensation | 68 | 49 | 35 |
| Defined contribution plans | 29 | 22 | 15 |
| Other social security costs | 25 | 15 | 21 |
| **Total**  | **514** | **363** | **253** |
| **Staff costs are included in the income statement as follows:** |  |  |  |
| Research and development expenses | 393 | 271 | 191 |
| Selling, general and administrative expenses | 121 | 92 | 62 |
| **Total** | **514** | **363** | **253** |
| **Average number of FTE** | **348** | **269** | **180** |
| **Number of FTE at year-end** | **385** | **312** | **210** |

---

Refer to Note 2.3 in the consolidated financial statements for additional information regarding staff costs of the Group.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 138/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### 4 – Corporate and Deferred Tax

#### TAXATION – INCOME STATEMENT & SHAREHOLDERS' EQUITY

---

| | | | |
|:---|:---|:---|:---|
|  | 2022 | 2021 | 2020 |
| (DKK million) |  |  |  |
| Current tax |  |  |  |
| &nbsp;&nbsp;Current tax on profit | 1508 | 959 | 1190 |
| &nbsp;&nbsp;Adjustment to deferred tax | 3 | 16 | (113) |
| **Total tax for the period in the income statement** | **1511** | **975** | **1077** |
| A reconciliation of Genmab's effective tax rate relative to the Danish statutory tax rate is as follows: |  |  |  |

---

---

| | | | |
|:---|:---|:---|:---|
|  | 2022 | 2021 | 2020 |
| (DKK million) |  |  |  |
| Net profit before tax | 6753 | 4873 | 5202 |
| **Tax at the Danish statutory corporation tax rate of 22% for all periods** | **1486** | **1072** | **1144** |
| **Tax effect of:** |  |  |  |
| &nbsp;&nbsp;Non-deductible expenses/non-taxable income and other permanent differences, net | 37 | (105) | (61) |
| &nbsp;&nbsp;All other | (12) | 8 | (6) |
| &nbsp;&nbsp;**Total tax effect** | **25** | **(97)** | **(67)** |
| **Total tax for the period in the income statement** | **1511** | **975** | **1077** |
| **Total tax for the period in shareholders' equity** | **(22)** | **(31)** | **(44)** |
| **Effective Tax Rate** | **22.4%** | **20.0%** | **20.7%** |

---

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 139/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### TAXATION – BALANCE SHEET
Significant components of the deferred tax asset are as follows:

---

| | | |
|:---|:---|:---|
|  | 2022 | 2021 |
| (DKK million) |  |  |
| Share-based instruments | 124 | 130 |
| Deferred revenue | 113 | 113 |
| Other temporary differences | 6 | 9 |
| **Total deferred tax assets** | **243** | **252** |

---

Refer to Note 2.4 in the consolidated financial statements for additional information regarding corporate and deferred tax of the Group.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 140/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### 5 – Intangible Assets

---

| | | | |
|:---|:---|:---|:---|
|  |  | **Licenses, Rights, and Patents** | **Licenses, Rights, and Patents** |
| **(DKK million)** |  | **2022** | **2021** |
| Cost at January 1 |  | 820 | 820 |
| Additions for the year |  | 191 | - |
| **Cost at December 31** |  | **1011** | **820** |
| Accumulated amortization and impairment at January 1 |  | (584) | (516) |
| Amortization for the year |  | (63) | (72) |
| Accumulated amortization |  | (7) | 4 |
| **Accumulated amortization and impairment at December 31** |  | **(654)** | **(584)** |
| **Carrying amount at December 31** |  | **357** | **236** |
| **(DKK million)** | **2022** | **2021** | **2020** |
| **Amortization and impairment included in the income statement as follows:** |  |  |  |
| Research and development expenses | 63 | 72 | 119 |
| **Total** | **63** | **72** | **119** |

---

Parent Company intangible assets include licenses and rights primarily to gain access to targets and technologies identified by third parties as well as subsidiaries.

Refer to Note 3.1 in the consolidated financial statements for additional information regarding intangible assets of the Group.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 141/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### 6 – Property and Equipment

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **Leasehold improvements** | **Equipment, furniture and fixtures** | **Assets under construction** | **Total property and equipment** |
| **(DKK million)** |  |  |  |  |
| **2022** |  |  |  |  |
| Cost at January 1 | 4 | 25 | 6 | 35 |
| Additions for the year | - | 6 | 11 | 17 |
| Disposals for the year | - | (7) | - | (7) |
| **Cost at December 31** | **4** | **24** | **17** | **45** |
| Accumulated depreciation and impairment at January 1 | (3) | (19) | - | (22) |
| Depreciation for the year | (1) | (5) | - | (6) |
| Disposals for the year | - | 9 | - | 9 |
| **Accumulated depreciation and impairment at December 31** | **(4)** | **(15)** | **-** | **(19)** |
| **Carrying amount at December 31** | **-** | **9** | **17** | **26** |
|  | **Leasehold improvements** | **Equipment, furniture and fixtures** | **Assets under construction** | **Total property and equipment** |
| **(DKK million)** |  |  |  |  |
| **2021** |  |  |  |  |
| Cost at January 1 | 4 | 23 | - | 27 |
| Additions for the year | - | 2 | 6 | 8 |
| **Cost at December 31** | **4** | **25** | **6** | **35** |
| Accumulated depreciation and impairment at January 1 | (2) | (15) | - | (17) |
| Depreciation for the year | (1) | (4) | - | (5) |
| **Accumulated depreciation and impairment at December 31** | **(3)** | **(19)** | **-** | **(22)** |
| **Carrying amount at December 31** | **1** | **6** | **6** | **13** |
|  | **2022** | **2021** | **2020** |  |
| **(DKK million)** |  |  |  |  |
| **Depreciation and impairment included in the income statement as follows:** |  |  |  |  |
| Research and development expenses | 2 | 3 | 3 |  |
| Selling, general and administrative expenses | 4 | 2 | 2 |  |
| **Total** | **6** | **5** | **5** |  |

---

Refer to Note 3.2 in the consolidated financial statements for additional information regarding property and equipment of the Group.

#### 7 – Leases
The parent company has entered into lease agreements with respect to office space.

The leases are non-cancellable over various periods through 2038.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 142/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

---

| | | | |
|:---|:---|:---|:---|
|  | December 31,<br>2022 | December 31,<br>2021 | December 31,<br>2020 |
| (DKK million) |  |  |  |
| **Right-of-use assets** |  |  |  |
| Balance at January 1 | 12 | 24 | 34 |
| Additions to right-of-use assets<sup>1</sup> | 10 | 1 | 3 |
| Depreciation charge for the year | (13) | (13) | (13) |
| **Balance at December 31** | **9** | **12** | **24** |
| **Lease liabilities** |  |  |  |
| Current | 5 | 11 | 12 |
| Non-current | - | - | 11 |
| **Total lease liabilities** | **5** | **11** | **23** |
| <sup>(1) Additions to right-of-use assets also includes modifications to existing leases and adjustments to the provisions for contractual restoration obligations related to leases of Genmab offices.</sup> |  |  |  |
| **Cash outflow for lease payments** | **13** | **13** | **13** |

---

Variable lease payments and lease interest expense are immaterial.

Future minimum payments under leases as of December 31, 2022, December 31, 2021 and December 31, 2020, are as follows:

---

| | | | |
|:---|:---|:---|:---|
|  | 2022 | 2021 | 2020 |
| (DKK million) |  |  |  |
| **Payment due**  |  |  |  |
| Less than 1 year | 5 | 11 | 12 |
| 1 to 3 years | - | - | 12 |
| More than 3 years but less than 5 years  | - | - | - |
| More than 5 years  | - | - | - |
| Total | **5** | **11** | **24** |

---

Future minimum payments under leases with commencement dates after December 31, 2022 are not included in the table above.

**Significant leases not yet commenced**

During 2020, Genmab entered into a lease agreement with respect to the new headquarters in Denmark with a commencement date in March 2023 and is non-cancellable until March 2038. The total future minimum payments over the term of the lease are approximately DKK 339 million and estimated capital expenditures to fit out the space are approximately DKK 128 million.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 143/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

Refer to Note 3.3 in the consolidated financial statements for additional information regarding leases of the Group.

#### 8 – Other Investments
Refer to Note 3.4 to the consolidated financial statements for additional information on other investments of the Group.

#### 9 – Receivables

---

| | | |
|:---|:---|:---|
|  | **2022** | **2021** |
| (DKK million) |  |  |
| Receivables related to collaboration agreements | 5257 | 2979 |
| Receivables from subsidiaries | 129 | 9 |
| Interest receivables | 83 | 37 |
| Other receivables  | 77 | 52 |
| Receivables for securities matured | 290 | - |
| Prepayments | 84 | 127 |
| **Total** | **5920**  | **3204**  |
| Non-current receivables | 35 | 8 |
| Current receivables | 5885 | 3196 |
| **Total** | **5920**  | **3204**  |

---

Refer to Note 3.5 in the consolidated financial statements for additional information regarding receivables of the Group.

#### 10 – Deferred Revenue

---

| | | |
|:---|:---|:---|
|  | 2022 | 2021 |
| (DKK million) |  |  |
| Deferred revenue at January 1 | 513 | 513 |
| Customer payment received | - | - |
| Revenue recognized during the year | - | - |
| **Total at December 31** | **513** | **513** |
| Non-current deferred revenue | 480 | 487 |
| Current deferred revenue | 33 | 26 |
| **Total at December 31** | **513** | **513** |

---

Refer to Note 3.6 in the consolidated financial statements for additional information regarding deferred revenue of the Group.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 144/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### 11 – Other Payables

---

| | | |
|:---|:---|:---|
|  | 2022 | 2021 |
| (DKK million) |  |  |
| Liabilities related to collaboration agreements | 70 | 53  |
| Staff cost liabilities  | 90 | 67  |
| Other liabilities  | 653 | 577  |
| Payable to subsidiaries  | 1136 | 770  |
| Provisions | 6 | 6 |
| Accounts payable | 90 | 135  |
| **Total at December 31** | **2045**  | **1608**  |
| Non-current other payables  | - | 6 |
| Current other payables  | 2045 | 1602 |
| **Total at December 31** | **2045**  | **1608**  |

---

Refer to Note 3.7 in the consolidated financial statements for additional information regarding other payables of the Group.

#### 12 – Marketable Securities
Refer to Note 4.4 to the consolidated financial statements for additional information on marketable securities of the Group.

#### 13 – Financial Income and Expenses

---

| | | | |
|:---|:---|:---|:---|
|  | 2022 | 2021 | 2020 |
| (DKK million) |  |  |  |
| **Financial income:** |  |  |  |
| Interest and other financial income | 321 | 190 | 184 |
| Interest from subsidiaries | - | 3 | - |
| Gain on other investments, net | 1 | - | 70 |
| Foreign exchange rate gain, net | 978 | 1417 | - |
|  |  |  | - |
| **Total financial income** | **1300** | **1610** | **254** |
| **Financial expenses:** |  |  |  |
| Interest and other financial expenses | (6) | (1) | (2) |
| Interest to subsidiaries | (2) | - | (3) |
| Loss on marketable securities, net | (361) | (246) | (91) |
| Loss on other investments, net | - | (7) | - |
| Foreign exchange rate loss, net | - | - | (1423) |
| **Total financial expenses** | **(369)** | **(254)** | **(1519)** |
| **Net financial items** | **931** | **1356** | **(1265)** |

---

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 145/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

Refer to Note 4.5 in the consolidated financial statements for additional information regarding financial income and expenses of the Group.

#### 14 – Remuneration of the Board of Directors and Executive Management
Remuneration of the Board of Directors for the parent is the same as the Group.

Remuneration of Executive Management for the parent company is 10% of total compensation for each member of Executive Management as reported in Note 5.1 in the consolidated financial statements, per service agreement with each member of Executive Management.

Refer to Note 5.1 in the consolidated financial statements for additional information regarding the remuneration of the Board of Directors and Executive Management.

#### 15 – Related Party Disclosures

#### Genmab A/S' related parties are the parent company's subsidiaries, Board of Directors, Executive Management, and close members of the family of these persons.

#### TRANSACTIONS WITH SUBSIDIARIES
Genmab B.V., Genmab Holding B.V., Genmab US, Inc. and Genmab K.K. are 100% (directly or indirectly) owned subsidiaries of Genmab A/S and are included in the consolidated financial statements. During 2022, various intercompany transactions and services between the aforementioned companies took place in the field of research and development, selling, general and administration, finance and management. All intercompany transactions have been eliminated in the consolidated financial statements of the Genmab Group.

---

| | | | |
|:---|:---|:---|:---|
|  | 2022 | 2021 | 2020 |
| (DKK million) |  |  |  |
| **Transactions with subsidiaries:** |  |  |  |
| *Income statement:* |  |  |  |
| Service fee income | 233 | 221 | 127 |
| Service fee costs | (4446) | (2675) | (1693) |
| Milestone costs | (1090) | - | - |
| Financial income | - | 3 | - |
| Financial expense | (2) | - | (3) |
| *Balance sheet:* |  |  |  |
| Intangible assets | 217 | 33 | 40 |
| Current receivables | 129 | 9 | 73 |
| Current payables  | (1136) | (770) | (358) |

---

Genmab A/S has placed at each subsidiary's disposal a credit facility (denominated in local currency) that the subsidiary may use to draw from in order to secure the necessary funding of its activities.

Refer to Note 5.2 to the consolidated financial statements for additional information regarding transactions with related parties of the Group.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 146/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### 16 – Investments in Subsidiaries

---

| | | |
|:---|:---|:---|
|  | 2022 | 2021 |
| (DKK million) |  |  |
| Cost at January 1 | 4435 | 3885 |
| Additions | 300 | 550 |
| **Cost at December 31** | **4735** | **4435** |
| Impairment at January 1 | (1929) | (1929) |
| **Impairment at December 31** | **(1929)** | **(1929)** |
| **Carrying amount at December 31** | **2806** | **2506** |

---

Refer to Note 1.1 in the consolidated financial statements for a listing of subsidiaries owned by Genmab A/S.

Refer to Note 1 in the parent financial statements for details of change in accounting policies impacting Genmab A/S investment in subsidiaries.

#### 17 – Commitments

#### PURCHASE OBLIGATIONS
Genmab A/S has entered into a number of agreements related to research and development activities that contain various obligations. These short-term contractual obligations amounted to approximately DKK 1,558 million as of December 31, 2022, all of which is due in less than two years (2021: approximately DKK 1,207 million).

Genmab A/S also has certain contingent commitments under our license and collaboration agreements that may become due in the future. As of December 31, 2022, these contingent commitments amounted to approximately DKK 14,537 million (USD 2,085 million) in potential future development, regulatory and commercial milestone payments to third parties under license and collaboration agreements for our pre-clinical and clinical stage development programs as compared to approximately DKK 14,371 million (USD 2,190 million) as of December 31, 2021. These milestone payments generally become due and payable only upon the achievement of certain development, clinical, regulatory or commercial milestones. The events triggering such payments or obligations have not yet occurred.

In addition to the above obligations, Genmab A/S enters into a variety of agreements and financial commitments in the normal course of business. The terms generally allow us the option to cancel, reschedule and adjust our requirements based on our business needs prior to the delivery of goods or performance of services. It is not possible to predict the maximum potential amount of future payments under these agreements due to the conditional nature of our obligations and the unique facts and circumstances involved in each particular agreement.

Refer to Note 5.3 in the consolidated financial statements for additional information regarding commitments of the Group.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 147/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### 18 – Fees to Auditors Appointed at the Annual General Meeting

---

| | | | |
|:---|:---|:---|:---|
|  | 2022 | 2021 | 2020 |
| (DKK million) |  |  |  |
| **PricewaterhouseCoopers** |  |  |  |
| Audit services | 5.8 | 5.8 | 4.9 |
| Audit-related services | 2.0 | 1.8 | 1.0 |
| Tax and VAT services | - | - | 0.3 |
| **Total**  | **7.8** | **7.6** | **6.2** |

---

Fees for other services than statutory audit of the financial statements provided by PricewaterhouseCoopers Statsautoriseret Revisionspartnerselskab amounted to DKK 2.0 million in 2022 (DKK 1.8 million in 2021 and DKK 1.3 million in 2020, respectively). These services primarily include agreed-upon procedures, other assurance assessments and reports, accounting advice, and tax and VAT compliance.

Refer to Note 5.4 in the consolidated financial statements for additional information regarding fees to auditors of the Group.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 148/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### 19 – Adjustments to Cash Flow Statements

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | Note | 2022 | 2021 | 2020 |
| (DKK million) |  |  |  |  |
| **Adjustments for non-cash transactions:** |  |  |  |  |
| Depreciation, amortization and impairment | 5, 6, 7 | 110 | 90 | 137 |
| Share-based compensation expenses | 3 | 62 | 49 | 40 |
| **Total adjustments for non-cash transactions** |  | **172** | **139** | **177** |
| **Change in operating assets and liabilities:** |  |  |  |  |
| Receivables |  | (2286) | (923) | 390 |
| Deferred revenue |  | - | - | 513 |
| Other payables  |  | 100 | (31) | 136 |
| **Total change in operating assets and liabilities** |  | **(2186)** | **(954)** | **1039** |

---

Refer to Note 5.5 in the consolidated financial statements for additional information regarding adjustments to the cash flow statement of the Group.

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 149/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

### Directors' and Management's Statement on the Annual Report
The Board of Directors and Executive Management have today considered and adopted the Annual Report of Genmab A/S for the financial year January 1 to December 31, 2022.

The Annual Report has been prepared in accordance with International Financial Reporting Standards (IFRS) as issued by the International Accounting Standards Board (IASB) and in accordance with IFRS as endorsed by the EU and further requirements in the Danish Financial Statements Act.

In our opinion, the Consolidated Financial Statements and the Parent Company Financial Statements give a true and fair view of the financial position at December 31, 2022 of the Group and the Parent Company and of the results of the Group and Parent Company operations and cash flows for 2022.

In our opinion, Management's Review includes a true and fair account of the development in the operations and financial circumstances of the Group and the Parent Company, of the results for the year and of the financial position of the Group and the Parent Company as well as a description of the most significant risks and elements of uncertainty facing the Group and the Parent Company.

In our opinion, the Annual Report of Genmab A/S for the financial year January 1 to December 31, 2022, with the file name 529900MTJPDPE4MHJ122-2022-12-31-en.zip is prepared, in all material respects, in compliance with the ESEF Regulation.

We recommend that the Annual Report be adopted at the Annual General Meeting.

Copenhagen, February 22, 2023

#### EXECUTIVE MANAGEMENT

---

| | | | | |
|:---|:---|:---|:---|:---|
| ![Graphic](gmab-20221231xex99d1021.jpg) | ![Graphic](gmab-20221231xex99d1022.jpg) | ![Graphic](gmab-20221231xex99d1023.jpg) | ![Graphic](gmab-20221231xex99d1024.jpg) | ![Graphic](gmab-20221231xex99d1025.jpg) |
| Jan van de Winkel | Anthony Pagano | Judith Klimovsky | Anthony Mancini | Tahamtan Ahmadi |
| (President & CEO) | (Executive Vice President & CFO) | (Executive Vice President & CDO) | (Executive Vice President & COO) | (Executive Vice President & CMO) |

---

#### BOARD OF DIRECTORS

---

| | | |
|:---|:---|:---|
| ![Graphic](gmab-20221231xex99d1026.jpg) | ![Graphic](gmab-20221231xex99d1027.jpg) | ![Graphic](gmab-20221231xex99d1028.jpg) |
| Deirdre P. Connelly | Pernille Erenbjerg | Anders Gersel Pedersen |
| (Chair) | (Deputy Chair) |  |
| ![Graphic](gmab-20221231xex99d1029.jpg) | ![Graphic](gmab-20221231xex99d1030.jpg) | ![Graphic](gmab-20221231xex99d1031.jpg) |
| Rolf Hoffmann | Paolo Paoletti | Elizabeth O'Farrell |
| ![Graphic](gmab-20221231xex99d1032.jpg) | ![Graphic](gmab-20221231xex99d1033.jpg) | ![Graphic](gmab-20221231xex99d1034.jpg) |
| Mijke Zachariasse | Takahiro Hamatani | Martin Schultz |
| (Employee elected) | (Employee elected) | (Employee elected) |

---

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 150/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

**Independent Auditor's Reports** 

To the shareholders of Genmab A/S

**Report on the audit of the Financial Statements**

**Our opinion**

In our opinion, the Consolidated Financial Statements and the Parent Company Financial Statements give a true and fair view of the Group's and the Parent Company's financial position at December 31, 2022 and of the results of the Group's and the Parent Company's operations and cash flows for the financial year January 1 to December 31, 2022 in accordance with International Financial Reporting Standards as issued by the International Accounting Standards Board and International Financial Reporting Standards as adopted by the EU and further requirements in the Danish Financial Statements Act.

Our opinion is consistent with our Auditor's Long-form Report to the Audit and Finance Committee and the Board of Directors.

*What we have audited*

The Consolidated Financial Statements and Parent Company Financial Statements of Genmab A/S for the financial year January 1 to December 31, 2022 comprise statement of comprehensive income, balance sheet, statement of cash flows, statement of changes in equity and notes, including summary of significant accounting policies for the Group as well as for the Parent Company. Collectively referred to as the "Financial Statements".

**Basis for opinion**

We conducted our audit in accordance with International Standards on Auditing (ISAs) and the additional requirements applicable in Denmark. Our responsibilities under those standards and requirements are further described in the *Auditor's responsibilities for the audit of the Financial Statements* section of our report.

We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our opinion.

*Independence*

We are independent of the Group in accordance with the International Ethics Standards Board for Accountants' International Code of Ethics for Professional Accountants (IESBA Code) and the additional ethical requirements applicable in Denmark. We have also fulfilled our other ethical responsibilities in accordance with these requirements and the IESBA Code.

To the best of our knowledge and belief, prohibited non-audit services referred to in Article 5(1) of Regulation (EU) No 537/2014 were not provided.

*Appointment*

Following the listing of the shares of Genmab A/S on Nasdaq Copenhagen, we were first appointed auditors of Genmab A/S on March 22, 2001 for the financial year 2001. We have been reappointed annually by shareholder resolution for a total period of uninterrupted engagement of 22 years including the financial year 2022.

**Key audit matters**

Key audit matters are those matters that, in our professional judgement, were of most significance in our audit of the Financial Statements for 2022. These matters were addressed in the context of our audit of the Financial Statements as a whole, and in forming our opinion thereon, and we do not provide a separate opinion on these matters.

---

| | |
|:---|:---|
| &nbsp;&nbsp;**Key audit matter** | &nbsp;&nbsp;**How our audit addressed the key audit matter** |
| &nbsp;&nbsp;*Revenue recognition of DARZALEX FASPRO*<br>In June 2022, the Group commenced binding  | &nbsp;&nbsp;<br>We tested certain internal controls over the process  |

---

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 151/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

---

| | |
|:---|:---|
| &nbsp;&nbsp;arbitration of matters arising under its license agreement with Janssen Biotech, Inc. (Janssen) relating to DARZALEX *FASPRO*. The arbitration is to settle whether Janssen is to pay milestone payments for the DARZALEX *FASPRO* as a separate product, and whether the Group is entitled to a new 13-year royalty term from the date of DARZALEX *FASPRO*'s first commercial sale. Based on discussions with in-house legal counsel, the Group has considered revenue subject to this arbitration as a variable consideration where it is not highly probable that the Group will not reverse this revenue in the future. Therefore, the Group has not recognized revenue in relation to the milestone payments, subject to the arbitration. The milestone payments constitute approximately DKK 2.8 billion (USD 405 million).<br>In relation to the revenue recognition of DARZALEX *FASPRO* it requires that Management make a significant judgement when determining the estimate of the variable consideration. We focused on the revenue recognition of DARZALEX *FASPRO* because estimating the variable consideration requires significant judgement by Management. <br>Reference is made to Note 5.6 in the Consolidated Financial Statements. | &nbsp;&nbsp;to record revenue, including controls related to the estimate of the variable consideration. <br>We evaluated and tested Management's process for determining the variable consideration and assessing the reasonableness of the estimate. This included (i) gaining an understanding of the Company's process around the accounting and reporting for the arbitration; (ii) discussing the status of the arbitration with the Company's in-house legal counsel as well as obtaining legal letter from the external legal counsel; (iii) evaluating the reasonableness of Management's estimate regarding recognition of the variable consideration; and (iv) evaluating the presentation and disclosure within the Financial Statements. |

---

**Statement on Management's Review**

Management is responsible for Management's Review.

Our opinion on the Financial Statements does not cover Management's Review, and we do not express any form of assurance conclusion thereon.

In connection with our audit of the Financial Statements, our responsibility is to read Management's Review and, in doing so, consider whether Management's Review is materially inconsistent with the Financial Statements, or our knowledge obtained in the audit, or otherwise appears to be materially misstated.

Moreover, we considered whether Management's Review includes the disclosures required by the Danish Financial Statements Act.

Based on the work we have performed, in our view, Management's Review is in accordance with the Consolidated Financial Statements and the Parent Company Financial Statements and has been prepared in accordance with the requirements of the Danish Financial Statements Act. We did not identify any material misstatement in Management's Review.

**Management's responsibilities for the Financial Statements**

Management is responsible for the preparation of consolidated financial statements and parent company financial statements that give a true and fair view in accordance with International Financial Reporting Standards as adopted by the EU and further requirements in the Danish Financial Statements Act, and for such internal control as Management determines is necessary to enable the preparation of financial statements that are free from material misstatement, whether due to fraud or error.

In preparing the Financial Statements, Management is responsible for assessing the Group's and the Parent Company's ability to continue as a going concern, disclosing, as applicable, matters related to going concern and using the going concern basis of accounting unless Management either intends to liquidate the Group or the Parent

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 152/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

Company or to cease operations, or has no realistic alternative but to do so.

**Auditor's responsibilities for the audit of the Financial Statements**

Our objectives are to obtain reasonable assurance about whether the Financial Statements as a whole are free from material misstatement, whether due to fraud or error, and to issue an auditor's report that includes our opinion. Reasonable assurance is a high level of assurance but is not a guarantee that an audit conducted in accordance with ISAs and the additional requirements applicable in Denmark will always detect a material misstatement when it exists. Misstatements can arise from fraud or error and are considered material if, individually or in the aggregate, they could reasonably be expected to influence the economic decisions of users taken on the basis of these Financial Statements.

As part of an audit in accordance with ISAs and the additional requirements applicable in Denmark, we exercise professional judgement and maintain professional skepticism throughout the audit. We also:

&nbsp;&nbsp;&nbsp;&nbsp;● Identify and assess the risks of material misstatement of the Financial Statements, whether due to fraud or error, design and perform audit procedures responsive to those risks, and obtain audit evidence that is sufficient and appropriate to provide a basis for our opinion. The risk of not detecting a material misstatement resulting from fraud is higher than for one resulting from error, as fraud may involve collusion, forgery, intentional omissions, misrepresentations, or the override of internal control.

&nbsp;&nbsp;&nbsp;&nbsp;● Obtain an understanding of internal control relevant to the audit in order to design audit procedures that are appropriate in the circumstances, but not for the purpose of expressing an opinion on the effectiveness of the Group's and the Parent Company's internal control.

&nbsp;&nbsp;&nbsp;&nbsp;● Evaluate the appropriateness of accounting policies used and the reasonableness of accounting estimates and related disclosures made by Management.

&nbsp;&nbsp;&nbsp;&nbsp;● Conclude on the appropriateness of Management's use of the going concern basis of accounting and based on the audit evidence obtained, whether a material uncertainty exists related to events or conditions that may cast significant doubt on the Group's and the Parent Company's ability to continue as a going concern. If we conclude that a material uncertainty exists, we are required to draw attention in our auditor's report to the related disclosures in the Financial Statements or, if such disclosures are inadequate, to modify our opinion. Our conclusions are based on the audit evidence obtained up to the date of our auditor's report. However, future events or conditions may cause the Group or the Parent Company to cease to continue as a going concern.

&nbsp;&nbsp;&nbsp;&nbsp;● Evaluate the overall presentation, structure and content of the Financial Statements, including the disclosures, and whether the Financial Statements represent the underlying transactions and events in a manner that gives a true and fair view.

&nbsp;&nbsp;&nbsp;&nbsp;● Obtain sufficient appropriate audit evidence regarding the financial information of the entities or business activities within the Group to express an opinion on the Consolidated Financial Statements. We are responsible for the direction, supervision and performance of the group audit. We remain solely responsible for our audit opinion.

We communicate with those charged with governance regarding, among other matters, the planned scope and timing of the audit and significant audit findings, including any significant deficiencies in internal control that we identify during our audit.

We also provide those charged with governance with a statement that we have complied with relevant ethical requirements regarding independence, and to communicate with them all relationships and other matters that may reasonably be thought to bear on our independence, and where applicable, actions taken to eliminate threats or safeguards applied.

From the matters communicated with those charged with governance, we determine those matters that were of most significance in the audit of the Financial Statements of the current period and are therefore the key audit matters. We describe these matters in our auditor's report unless law or regulation precludes public disclosure about the matter.

**Report on compliance with the ESEF Regulation**

As part of our audit of the Financial Statements we performed procedures to express an opinion on whether the annual report of Genmab A/S for the financial year January 1 to December 31, 2022 with the file name

---

| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 153/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

---

![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

529900MTJPDPE4MHJ122-2022-12-31-en.zip is prepared, in all material respects, in compliance with the Commission Delegated Regulation (EU) 2019/815 on the European Single Electronic Format (ESEF Regulation) which includes requirements related to the preparation of the annual report in XHTML format and iXBRL tagging of the Consolidated Financial Statements including notes.

Management is responsible for preparing an annual report that complies with the ESEF Regulation. This responsibility includes:

&nbsp;&nbsp;&nbsp;&nbsp;● The preparing of the annual report in XHTML format;

&nbsp;&nbsp;&nbsp;&nbsp;● The selection and application of appropriate iXBRL tags, including extensions to the ESEF taxonomy and the anchoring thereof to elements in the taxonomy, for all financial information required to be tagged using judgement where necessary;

&nbsp;&nbsp;&nbsp;&nbsp;● Ensuring consistency between iXBRL tagged data and the Consolidated Financial Statements presented in human-readable format; and

&nbsp;&nbsp;&nbsp;&nbsp;● For such internal control as Management determines necessary to enable the preparation of an annual report that is compliant with the ESEF Regulation.

Our responsibility is to obtain reasonable assurance on whether the annual report is prepared, in all material respects, in compliance with the ESEF Regulation based on the evidence we have obtained, and to issue a report that includes our opinion. The nature, timing and extent of procedures selected depend on the auditor's judgement, including the assessment of the risks of material departures from the requirements set out in the ESEF Regulation, whether due to fraud or error. The procedures include:

&nbsp;&nbsp;&nbsp;&nbsp;● Testing whether the annual report is prepared in XHTML format;

&nbsp;&nbsp;&nbsp;&nbsp;● Obtaining an understanding of the company's iXBRL tagging process and of internal control over the tagging process;

&nbsp;&nbsp;&nbsp;&nbsp;● Evaluating the completeness of the iXBRL tagging of the Consolidated Financial Statements including notes;

&nbsp;&nbsp;&nbsp;&nbsp;● Evaluating the appropriateness of the company's use of iXBRL elements selected from the ESEF taxonomy and the creation of extension elements where no suitable element in the ESEF taxonomy has been identified;

&nbsp;&nbsp;&nbsp;&nbsp;● Evaluating the use of anchoring of extension elements to elements in the ESEF taxonomy; and

&nbsp;&nbsp;&nbsp;&nbsp;● Reconciling the iXBRL tagged data with the audited Consolidated Financial Statements.

In our opinion, the annual report of Genmab A/S for the financial year January 1 to December 31, 2022 with the file name 529900MTJPDPE4MHJ122-2022-12-31-en.zip is prepared, in all material respects, in compliance with the ESEF Regulation.

Hellerup, February 22, 2023

PricewaterhouseCoopers

Statsautoriseret Revisionspartnerselskab

CVR no 3377 1231

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|:---|:---|
| &nbsp;&nbsp;![Graphic](gmab-20221231xex99d1035.jpg) | &nbsp;&nbsp;![Graphic](gmab-20221231xex99d1036.jpg) |
| &nbsp;&nbsp;Torben Jensen | &nbsp;&nbsp;Henrik Trangeled Kristensen |
| &nbsp;&nbsp;State Authorised Public Accountant | &nbsp;&nbsp;State Authorised Public Accountant |
| &nbsp;&nbsp;mne18651 | &nbsp;&nbsp;mne23333 |

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| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 154/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### Other Information

#### Glossary

---

| | |
|:---|:---|
| &nbsp;&nbsp;**American Depository Shares (ADSs)** | &nbsp;&nbsp;A U.S. dollar-denominated equity share of a foreign-based company available for purchase on an American stock exchange. |
| &nbsp;&nbsp;**Antibody-drug conjugate (ADC)** | &nbsp;&nbsp;Antibody with potent cytotoxic agents (toxins) coupled to it.  |
| &nbsp;&nbsp;**Antigen** | &nbsp;&nbsp;Immunogen. A target molecule that is specifically bound by an antibody.  |
| &nbsp;&nbsp;**Apoptosis** | &nbsp;&nbsp;A form of programmed cell death. |
| &nbsp;&nbsp;**Biologics License Application (BLA)** | &nbsp;&nbsp;A submission to apply for marketing approval from the U.S. FDA, which contains specific information on the manufacturing processes, chemistry, pharmacology, clinical pharmacology and the medical effects of a biologic product. |
| &nbsp;&nbsp;**Bispecific antibody** | &nbsp;&nbsp;An antibody in which the two binding regions are not identical, with each region directed against two different antigens or against two different sites on the same antigen.  |
| &nbsp;&nbsp;**Building Research Establishment Environmental Assessment Method (BREEAM)** | &nbsp;&nbsp;A sustainability assessment method for infrastructure and buildings. |
| &nbsp;&nbsp;**Clinical** | &nbsp;&nbsp;Term used to refer to drugs that are at the stage of being investigated in humans to determine the safety and efficacy of the drug before it can be submitted for approval by regulatory authorities. |
| &nbsp;&nbsp;**Complement dependent cytotoxicity (CDC)** | &nbsp;&nbsp;An antibody effector function that eliminates target cells. |
| &nbsp;&nbsp;**Corporate Social Responsibility (CSR)** | &nbsp;&nbsp;Business model that enables a corporation to be socially accountable to itself, its stakeholders and its community. |
| &nbsp;&nbsp;**Cytotoxic** | &nbsp;&nbsp;Toxic to living cells.  |
| &nbsp;&nbsp;**Dual-listed company** | &nbsp;&nbsp;A company whose shares are traded on two stock markets. |
| &nbsp;&nbsp;**Epitope** | &nbsp;&nbsp;The specific surface portion of an antigen to which an antibody binds. Upon binding of the antibody to the epitope an immune response is elicited.  |

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| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 155/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

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| | |
|:---|:---|
| &nbsp;&nbsp;**Environmental, Social and Governance (ESG)** | &nbsp;&nbsp;Set of standards for a company's operations. |
| &nbsp;&nbsp;**European Medicines Agency (EMA)** | &nbsp;&nbsp;European regulatory agency that facilitates development and access to medicines, evaluates applications for marketing authorization and monitors the safety of medicines. |
| &nbsp;&nbsp;**Hexamerization** | &nbsp;&nbsp;The ordered clustering of six antibodies. |
| &nbsp;&nbsp;**Immunomodulatory agent** | &nbsp;&nbsp;A type of drug used to treat certain types of cancers, such as multiple myeloma. Examples include lenalidomide and pomalidomide. |
| &nbsp;&nbsp;**Leadership in Energy and Environmental Design (LEED)**  | &nbsp;&nbsp;Globally recognized green building rating system.  |
| &nbsp;&nbsp;**Monoclonal** | &nbsp;&nbsp;Derived from a single cell. Monoclonal antibodies derived from such single cell will be identical. |
| &nbsp;&nbsp;**Monotherapy** | &nbsp;&nbsp;Treatment of a medical condition by use of a single drug.  |
| &nbsp;&nbsp;**Pre-clinical** | &nbsp;&nbsp;Term used to refer to products that are at the stage of being investigated in the laboratory or in animals to determine the safety and efficacy of the product before it is evaluated in humans. |
| &nbsp;&nbsp;**Priority Review** | &nbsp;&nbsp;U.S. FDA designation used for drugs that, if approved, would be significant improvements in the safety or effectiveness of the treatment, diagnosis, or prevention of serious conditions when compared to standard applications.  |
| &nbsp;&nbsp;**Progression free survival (PFS)** | &nbsp;&nbsp;Progression free survival. The length of time a patient lives without his/her disease worsening. |
| &nbsp;&nbsp;**Proteasome inhibitor (PI)** | &nbsp;&nbsp;A type of drug used to treat certain types of cancer, such as multiple myeloma. Examples include bortezomib and carfilzomib. |
| &nbsp;&nbsp;**Subcutaneous (SC)** | &nbsp;&nbsp;Applied under the skin. |
| &nbsp;&nbsp;**Target** | &nbsp;&nbsp;A molecule of potential interest against which an antibody is raised/created.  |
| &nbsp;&nbsp;**Transgenic mouse** | &nbsp;&nbsp;A mouse carrying a transgene from a foreign species, typically a human, which transgene has been introduced into the replicating cells of the mouse, so the transgene is passed on  |

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| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 156/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

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| | |
|:---|:---|
|  | &nbsp;&nbsp;to future generations/offspring of the transgenic mouse.  |
| &nbsp;&nbsp;**U.S. Food and Drug Administration (U.S. FDA)** | &nbsp;&nbsp;U.S. regulatory agency responsible for ensuring the safety, efficacy and security of human and veterinary drugs, biological products and medical devices. |

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#### Forward-looking Statement
This Annual Report contains forward looking statements. The words "believe," "expect," "anticipate," "intend" and "plan" and similar expressions identify forward looking statements. Actual results or performance may differ materially from any future results or performance expressed or implied by such statements. The important factors that could cause our actual results or performance to differ materially include, among others, risks associated with product discovery and development, uncertainties related to the outcome and conduct of clinical trials including unforeseen safety issues, uncertainties related to product manufacturing, our inability to manage growth, the competitive environment in relation to our business area and markets, our inability to attract and retain suitably qualified personnel, the unenforceability or lack of protection of our patents and proprietary rights, our relationships with affiliated entities, changes and developments in technology which may render our products obsolete, and other factors. Additional factors that could cause our actual results or performance to differ materially could also include and are not limited to the risk and uncertainties related to regulatory action, reimbursement, market adoption by physicians or lack of market acceptance of our products, the risk that the company or our collaborators may be delayed or unsuccessful in planned clinical trial initiations, enrollment and planned regulatory submissions and approvals in the U.S. and other countries. For a further discussion of these risks, please refer to the section "Risk Management" in this Annual Report and the risk factors included in Genmab's 2022 Annual Report on Form 20-F and other filings with the U.S. Securities and Exchange Commission (SEC). Genmab does not undertake any obligation to update or revise forward looking statements in this Annual Report nor to confirm such statements to reflect subsequent events or circumstances after the date made or in relation to actual results, unless required by law.

Genmab A/S and/or its subsidiaries own the following trademarks: Genmab<sup>®</sup>; the Y-shaped Genmab logo<sup>®</sup>; Genmab in combination with the Y-shaped Genmab logo<sup>®</sup>; HuMax<sup>®</sup>; DuoBody<sup>®</sup>; DuoBody in combination with the DuoBody logo<sup>®</sup>; HexaBody<sup>®</sup>; HexaBody in combination with the HexaBody logo<sup>®</sup>; DuoHexaBody<sup>®</sup> and HexElect<sup>®</sup>. Tivdak<sup>®</sup> is a trademark of Seagen Inc.; Arzerra<sup>®</sup> is a trademark of Novartis Pharma AG. Kesimpta<sup>®</sup> and Sensoready<sup>®</sup> are trademarks of Novartis AG or its affiliates; DARZALEX<sup>®</sup>, DARZALEX *FASPRO*<sup>®</sup>, RYBREVANT<sup>®</sup>, and TECVAYLI<sup>®</sup> are trademarks of Johnson & Johnson; EPCORE™ is a trademark of AbbVie Biotechnology Ltd.; TEPEZZA<sup>®</sup> is a trademark of Horizon Therapeutics Ireland DAC.©2023, Genmab A/S. All rights reserved.

**Photograph credits:**

Andrei Jackamets

Tuala Hjarnø

3FX, Inc.

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| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 157/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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![Graphic](gmab-20221231xex99d1002.jpg)

**GENMAB 2022 ANNUAL REPORT** 

#### About Genmab A/S
**Genmab is an international biotechnology company with a core purpose guiding its unstoppable team to strive towards improving the lives of patients through innovative and differentiated antibody therapeutics. For more than 20 years, its passionate, innovative and collaborative team has invented next-generation antibody technology platforms and leveraged translational research and data sciences, which has resulted in a proprietary pipeline including bispecific T-cell engagers, next-generation immune checkpoint modulators, effector function enhanced antibodies and antibody-drug conjugates.** 

**To help develop and deliver novel antibody therapies to patients, Genmab has formed 20+ strategic partnerships with biotechnology and pharmaceutical companies. By 2030, Genmab's vision is to transform the lives of people with cancer and other serious diseases with Knock-Your-Socks-Off (KYSO) antibody medicines.**

Established in 1999, Genmab is headquartered in Copenhagen, Denmark with locations in Utrecht, the Netherlands, Princeton, New Jersey, U.S. and Tokyo, Japan. For more information, please visit Genmab.com and follow us on Twitter.com/Genmab.

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| | |
|:---|:---|
| &nbsp;&nbsp;**Addresses**<br>**GENMAB A/S**<br>Kalvebod Brygge 43<br>1560 Copenhagen V<br>Denmark<br>&nbsp;&nbsp;&nbsp;&nbsp;T. +45 70 20 27 28<br>**GENMAB US, INC.**<br>777 Scudders Mill Road<br>Plainsboro, NJ 08536<br>USA<br>T. +1 609 430 2481 | &nbsp;&nbsp;**GENMAB B.V. & GENMAB HOLDING B.V.**<br>Uppsalalaan 15<br>3584 CT Utrecht<br>The Netherlands<br>&nbsp;&nbsp;&nbsp;&nbsp;T. +31 30 2 123 123<br>**GENMAB K.K.**<br>35F Midtown Tower<br>9-7-1 Akasaka, Minato-ku<br>Tokyo 107-6235<br>Japan<br>&nbsp;&nbsp;&nbsp;&nbsp;T. +81 3 5403 6330<br>www.genmab.com<br>LEI Code 529900MTJPDPE4MHJ122 |

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| | | |
|:---|:---|:---|
| Genmab A/S | Tel: +45 7020 2728 | Company Announcement no. 05 |
| Kalvebod Brygge 43 |  | Page 158/158 |
| 1560 Copenhagen V, Denmark | www.genmab.com | CVR no. 2102 3884 |

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## Exhibit 99.1

#### Exhibit 99.1a

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| | |
|:---|:---|
| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag001.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2022 Annual Report Rooted in Science, Inspired by Patients CVR No. 21 02 38 84 Genmab A/S Kalvebod Brygge 43 1560 Copenhagen V Denmark |

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|:---|:---|
| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag002.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2 Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Financial Statements Other Information Management's Review 4 Our Vision 5 Chair's Statement 7 Letter from the CEO 9 2022 at a Glance 10 Consolidated Key Figures 11 2023 Outlook 12 Our Strategy 13 Who We Are 14 Business Model 15 Research and Development Capabilities 16 Enhancing Commercialization Capabilities to Bring Our Innovations to Patients 17 Antibody Discovery and Development 18 Products and Technologies 43 Corporate Social Responsibility and Sustainability Commitments 46 Genmab's Task Force on Climate-related Financial Disclosures 49 Stakeholder Engagement 51 Human Capital Management 52 Financial Review 60 Risk Management 65 Enterprise Risk Management 66 Corporate Governance 68 Board of Directors 71 Senior Leadership 73 Shareholders and Share Information Financial Statements 76 Financial Statements for the Genmab Group 116 Financial Statements of the Parent Company 132 Directors' and Management's Statement on the Annual Report 133 Independent Auditor's Reports Other Information 137 Glossary 138 Forward-looking Statement 139 Contact Information **Table of Contents** Our Reporting Suite 2022 Corporate Responsibility Report (https://ir.genmab.com/static-files/ 72218610-90a6-4fd3-a76a-d4a7c9c6ef01) 2022 Corporate Governance Report 2022 Compensation Report Our Corporate Responsibility, Corporate Governance and Compensation Reports for 2022 can be found on our website, Genmab.com. |

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| | |
|:---|:---|
| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag003.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Management's Review **Table of Contents** Financial Statements Other Information 3 Genmab \| 2022 Annual Report \| Management's Review Management's Review |

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|:---|:---|
| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag004.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review By 2030, our KYSO (knock-your-socks-off) antibody medicines are fundamentally transforming the lives of people with cancer and other serious diseases. Our 2030 Vision Our Core Purpose Supporting our 2030 Vision is our core purpose—our unstoppable team will improve the lives of patients through innovative and differentiated antibody therapeutics. |

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|:---|:---|
| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag005.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Financial Statements Other Information Management's Review **Table of Contents** 5 Genmab \| 2022 Annual Report \| Management's Review Chair's Statement Deirdre P. Connelly Board Chair Dear Shareholder, At Genmab, we strive to be innovative and forward-thinking in everything we do, not just in our approach to discovering and developing differentiated antibody therapeutics. As a result, in 2022 the unstoppable team at Genmab built on our already solid foundation with progress throughout our business. Commitment to Sustainability and the Environment Over the past year, we continued our business-driven corporate responsibility strategy with an emphasis on measuring our carbon footprint, setting climate ambitions and targets, and improving our climate-related disclosures. We remained committed to our three previously selected United Nations Sustainable Development Goals (UNSDGs), and added an additional UNSDG, Goal 13: Climate Action. We are also dedicated to transparency and the continued improvement of our climate disclo-sures. We have included in our Annual Report our disclosures in accordance with the Task Force on Climate-related Financial Disclosures (TCFD) recommendations. In addition, we have an intention to commit to a climate target to reduce our greenhouse gas (GHG) emissions in line with the Paris Agreement. Because of our focus on sustainability, Genmab scores well on external benchmarking for environmental, social and governance (ESG) and we continually seek ways to improve and remain compliant with existing and new requirements. In 2023, we At Genmab, we strive to be innovative and forward-thinking in everything we do, not just in our approach to discovering and developing differentiated antibody therapeutics. |

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|:---|:---|
| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag006.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Chair's Statement will continue our commitment to environmental responsibility and sustainability and will look for opportunities to further integrate this commit-ment into our business. I encourage you to read our 2022 Corporate Responsibility Report for more information. Experienced Leadership In 2022, we further strengthened our Senior Leadership team with the appointments of Birgitte Stephensen to Chief Legal Officer and Chris Cozic to Chief People Officer. Both leaders have experi-ence in their fields, within and outside of Genmab. Birgitte Stephensen joined Genmab in 2002 and previously served as Genmab's Senior Vice President, Intellectual Property Rights and Legal. Chris Cozic joined Genmab in 2017 and most recently served as Senior Vice President, Global Human Resources. We also saw a change to our Board of Directors with the election of Elizabeth O'Farrell at Genmab's 2022 Annual General Meeting. During her 24-year career at Eli Lilly, Ms. O'Farrell served as CFO of some of the company's largest businesses, including as Head of Global Finance Operations. She has solid financial experience including strategic, operational and financial decision-making and reporting across the value chain as well as expertise in driving global change initiatives. On behalf of the Board of Directors, I would like to thank Genmab's dedicated team members, CEO Jan van de Winkel and the entire global leadership team for their inspiration and extraordinary leadership as well as our shareholders for their continued support. Sincerely, Deirdre P. Connelly Board Chair Over the past year, we continued to focus on our business-driven corporate responsibility strategy with an emphasis on measuring our carbon footprint, setting climate ambitions and targets, and improving our climate-related disclosures.  |

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|:---|:---|
| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag007.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Financial Statements Other Information Management's Review **Table of Contents** 7 Genmab \| 2022 Annual Report \| Management's Review Letter from the CEO Jan van de Winkel, Ph.D. President & Chief Executive Officer We believe that with our unstoppable team we can improve the lives of patients through innovative and differentiated antibody therapeutics. Dear Shareholder, A Successful Strategy When I became CEO of Genmab in 2010 there was an imperative to outline a new strategy—one that would reposition the company to become financially sustainable and allow us to invest in our world-class antibody products and tech-nologies. That three-pronged strategy—to turn science into medicine, build a profitable and successful biotech and focus on our core competence—led quickly to success. Just two years after we unveiled this strategy, we entered into two agreements with Janssen Biotech, Inc. (Janssen) that subsequently resulted in multiple approved medicines: DARZALEX® (daratumumab) and DARZALEX FASPRO® (dara-tumumab and hyaluronidase-fihj) and the first approved DuoBody®-based antibody therapies RYBREVANT® (amivantamab) and TECVAYLI® (teclistamab). There is potential for an addi-tional DuoBody-based medicine from this collaboration, as Janssen submitted a Biologics License Application (BLA) in December to the U.S. Food and Drug Administration (U.S. FDA) for talquetamab. The approved medicines form part of the recurring revenue streams that we use to invest back into our company's pipeline, technology and people. The results of this investment were on display in 2022. We celebrated the first full year of Genmab's first approved medicine, Tivdak® (tisotumab vedotin-tftv), co-developed with Seagen Inc. (Seagen), being available for certain cervical cancer patients in the U.S. We submitted applications for our own DuoBody-based inves-tigational medicine, epcoritamab, for approval in the U.S. and Japan and our partner AbbVie Inc. (AbbVie) followed suit in Europe. We expanded and advanced our clinical and pre-clinical port-folios, including an expansion of our successful collaboration with BioNTech SE (BioNTech), and we further scaled our organization to be aligned  |

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|:---|:---|
| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag008.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review with our portfolio growth and potential future product launches. A Vision Rooted in Science, Inspired by Patients Soon after we launched our successful strategy, we articulated an ambitious vision for the company—that by 2025, our own product has transformed cancer treatment, and we have a pipeline of KYSO antibodies. To support this vision, we outlined how we would build our capa-bilities and teams, and we aligned on a series of goals and milestones that we committed to reaching by 2025. These ambitious goals were a roadmap to becoming the company that we knew we could be. I am proud that we have met most of those goals and many more are within reach, giving us an extremely solid foundation on which to continue to build Genmab. With these achieve-ments, we felt that it was time to look beyond our 2025 Vision to continue impacting the lives of patients and the healthcare community into the future. Together with members of Genmab's leadership team and colleagues throughout the organization, we discussed what would make us feel proud in 2030. We have captured our aspi-rations for the future with a new vision, that by 2030, our KYSO antibody medicines are funda-mentally transforming the lives of people with cancer and other serious diseases. Our 2030 Vision is not a reimagining of what Genmab is, but a bold expansion of what Genmab can be and how our unstoppable team aspires to use our innovation in antibody therapeutics to fundamentally transform the lives of patients. We know that our antibody know-how, assets and technologies can be applied to diseases outside cancer—the approvals of Novartis AG (Novartis)'s Kesimpta® (ofatumumab) in relapsing multiple sclerosis (RMS) and Horizon Therapeutics, plc (Horizon)'s TEPEZZA® (teprotumumab-trbw) in thyroid eye disease (TED) are proof of this. While we will continue to create and develop new treatment concepts in oncology, we will apply a rigorous approach in identifying areas outside of oncology where our science and expertise may potentially make the biggest difference for patients, with the ultimate goal of improving the lives of as many people as possible. An Unstoppable Team, a KYSO Future As a co-founder of Genmab, I am extremely motivated by the progress we have made, both since I became CEO and over the past year. As a scientist and immunologist, I am truly excited by the potential of our antibodies and by the possibilities for Genmab in 2023, 2030 and beyond. I can say with confidence that this is not my story alone or the story of our global leadership team — it is the story of our talented and unstoppable Genmab team, of our collaboration partners who believe in the power of antibody therapies, of our supportive Board of Directors, the patients who participate in our clinical trials and their families, the investigators who help us trailblaze innovations, and our shareholders Letter from the CEO who believe in our vision. We are at the beginning of a fantastic KYSO future that we are creating together, and I thank you for your continued support. Sincerely yours, Jan van de Winkel, Ph.D. President & Chief Executive Officer Our 2030 Vision is not a reimagining of what Genmab is, but a bold expansion of what Genmab can be. |

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|:---|:---|
| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag009.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;9 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** 2022 at a Glance Operational U.S. FDA granted orphan-drug designation to epcoritamab for the treatment of follicular lymphoma (FL) Publication by Genmab and collaboration partner AbbVie of topline results from the large B-cell lymphoma (LBCL) cohort of the pivotal EPCORE™ NHL-1 epcoritamab study New Phase 3 study for epcoritamab initiated Regulatory submissions for subcutaneous (SC) epcoritamab in the U.S. and Japan by Genmab and in Europe by AbbVie Epcoritamab BLA accepted for Priority Review by the U.S. FDA with a Prescription Drug User Fee Act (PDUFA) target action date of May 21, 2023 Epcoritamab Marketing Authorization Application (MAA) validated by the European Medicines Agency (EMA) First full year of Tivdak, co-development with Seagen, available for certain cervical cancer patients in the U.S. Continued development of commercialization capabilities and Genmab's broader organizational infrastructure with the addition of 448 new colleagues Expansion of global strategic collaboration with BioNTech, including investigational medicine HexaBody®-CD27 (GEN1053/BNT313) Second DuoBody-based medicine to receive regulatory approval: Janssen's TECVAYLI Financial Liquidity and Capital Resources DKK 12,431M Marketable securities DKK 9,893M Cash and cash equivalents DKK 27,441M Shareholders' equity 2020 Operating Profit impacted by one-time AbbVie upfront payment. DKK 194B 2022 year-end market cap DKK 14,595M 2022 revenue DKK 8,238M 2022 operating expenses 68% invested in research and development (R&D) Operating Profit (DKK million) 2018 2019 2020 2021 2022 1,380 2,638 6,313 3,018 6,357 |

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|:---|:---|
| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag010.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Consolidated Key Figures (DKK million) 2018\* 2019 2020 2021 2022 Income Statement Revenue 3,025 5,366 10,111 8,482 14,595 Research and development expenses (1431) (2386) (3137) (4181) (5562) Selling, general and administrative expenses (214) (342) (661) (1283) (2676) Operating expenses (1645) (2728) (3798) (5464) (8238) Operating profit 1,380 2,638 6,313 3,018 6,357 Net financial items 232 221 (409) 965 678 Net profit 1,472 2,166 4,758 3,008 5,522 Balance Sheet Marketable securities 5,573 7,419 8,819 10,381 12,431 Cash and cash equivalents 533 3,552 7,260 8,957 9,893 Total non-current assets 1,028 1,183 2,352 1,891 1,901 Total assets 8,461 15,144 21,143 24,627 30,278 Shareholders' equity 8,014 14,048 19,121 22,196 27,441 Share capital 61 65 66 66 66 Cash Flow Statement Cash flow from operating activities 1,015 1,326 6,433 2,228 3,912 Cash flow from investing activities (1778) (1983) (2351) (961) (2761) Cash flow from financing activities (71) 3,660 71 (420) (789) Investments in intangible and tangible assets (478) (111) (307) (252) (317) Financial Ratios and Other Information Basic net profit per share 24.03 34.40 73.00 46.00 84.45 Diluted net profit per share 23.73 34.03 72.21 45.54 83.65 Year-end share market price 1,067.50 1,481.50 2,463.00 2,630.00 2,941.00 Price/book value 8.19 6.85 8.50 7.82 7.07 Shareholders' equity per share 130.32 216.12 289.71 336.30 415.77 Equity ratio 95% 93% 90% 90% 91% Shares outstanding 61,497,571 65,074,502 65,545,748 65,718,456 65,961,573 Average number of employees (FTE)\*\* 313 471 656 1,022 1,460 Number of employees (FTE) at year-end 377 548 781 1,212 1,660 \*Prior period amounts have not been adjusted under the modified retrospective method to adopt International Financial Reporting Standards (IFRS) 16 as of January 1, 2019 \*\*Full-time equivalent (FTE) or team members Revenue (DKK million) Operating Expenses (DKK million) FTE at Year End FTE 214 342 661 1,431 2,386 3,137 1,283 2,676 4,181 5,562 2018 2019 2020 2021 2022 1,645 2,728 3,798 8,238 5,464 2018 2019 2020 2021 2022 3,025 5,366 10,111 14,595 8,482 2018 2019 2020 2021 2022 377 548 781 1,660 1,212 R&D SG&A\* \*Selling, general, and administrative expenses |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag012.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;12 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Our Strategy Business Strategy Priorities in 2022 Priorities for 2023 Link to Risk Build a profitable and successful biotech ― Maintain a flexible and capital-efficient model ― Maximize relationships with partners ― Retain ownership of select products Further scale organization aligned with growing product portfolio and brand needs ― Further scale organization aligned with differentiated antibody product portfolio growth and future launches ― Use solid financial base to grow and broaden antibody product and technology portfolio Invest in our people and culture ― Further scale organization aligned with differentiated antibody product portfolio growth and future launches Become a leading integrated biotech innovation powerhouse ― Use solid financial base to grow and broaden antibody product and technology portfolio Please refer to the risks included in this Annual Report. Focus on core competence ― Identify the best disease targets ― Develop unique first-in-class or best-in-class antibodies ― Develop next-generation technologies Growth and development of differentiated early-stage product candidates ― DuoBody-PD-L1x4-1BB1 & DuoBody-CD40x4-1BB1 ― Data from clinical expansion cohorts to progress to next steps ― Expand and advance proprietary clinical product portfolio Build a world-class differentiated pipeline ― DuoBody-PD-L1x4-1BB ― Establish proof of concept data in solid tumor indication ― DuoBody-CD40x4-1BB ― Establish efficacy and safety data in solid tumor indication ― Progress towards late-stage clinical development ― Expand and advance proprietary clinical product portfolio Please refer to the risks included in this Annual Report. Turn science into medicine ― Create differentiated antibody therapeutics with significant commercial potential Broad and rapid development of late-stage clinical pipeline and further build U.S. country organization ― Epcoritamab2 ― Expand clinical development program with multiple Phase 3 trials initiated and submission of first BLA (subject to supportive U.S. FDA feedback) ― Tivdak3 ― Establish Tivdak as a clear choice for second-line (2L) + recurrent or metastatic cervical cancer patients ― Broaden clinical development program including Phase 2 evaluation of combination therapy in earlier line treatment for cervical cancer and other solid tumors Bring our own medicines to patients ― Epcoritamab ― Launch in relapsed/refractory diffuse large B-cell lymphoma (DLBCL)4 ― Submit a supplemental BLA (sBLA)5 ― Broaden clinical development program ― Tivdak ― Progress successful uptake in 2L+ recurrent or metastatic cervical cancer patients ― Progress clinical development program Please refer to the risks included in this Annual Report. CSR Strategy Priorities in 2022 Priorities for 2023 Link to Risk Commitment to our business-driven Corporate Social Responsibility (CSR) strategy, which focuses on four pillars: ― Science-driven health innovations for patients ― Employee well-being and vitality ― Ethics and transparency ― Environmental and community sustainability ― Continue strong commitment to being a responsible and sustainable biotech ― Look for opportunities to further integrate ESG into our strategic planning and risk management processes ― Monitor ESG matters of relevance to our business operations ― Establish clear goals to measure our performance ― Establish climate ambitions, targets, and emissions reductions and integrate climate-related financial risks into Genmab's Enterprise Risk Management (ERM) program ― Continue strong commitment to being a sustainable and responsible company ― Further integrate ESG into our strategic planning, operations and risk management processes ― Further formalize total CO2 emissions mapping ― Further define and communicate Genmab's commitment to successfully attract, motivate, retain and reward top talent ― Enhance Diversity, Equity and Inclusion (DE&I) processes and efforts ― Monitor regulatory landscape and prepare for new ESG-related reporting requirements Please refer to the risks included in Genmab's 2022 Corporate Responsibility report, https://ir.genmab.com/ static-files/72218610- 90a6-4fd3-a76a-d4a7c9c6ef01 1. Co-development with BioNTech; 2. Co-development with AbbVie; 3. Co-development with Seagen; 4. Subject to regulatory approvals; 5. Subject to supportive U.S. FDA feedback |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag014.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;14 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Our Strengths and Differentiators The Value We Create for Stakeholders Building a Fully Integrated Biotech Innovation Powerhouse World-class antibody biology knowledge and deep insight into disease targets Discovery and development engine with proprietary technologies that allow us to build a world-class pipeline In-house expertise with a solid track record of building successful strategic partnerships Robust pipeline of potential best-in-class and first-in-class therapies Experienced, diverse leadership team Business Model At Genmab, we have built a profitable and successful biotech that creates value for our stakeholders. Patients 25 Ongoing or announced clinical trials with Genmab owned (≥50%) products Our People >448 New full-time jobs created in 2022 Investors 12% Increase in market capitalization in 2022 Collaborations Research agreements and collaborations in place across innovation ecosystem of pharma, biotech and academia Team: Flexible and adaptive infrastructure Strong Financials: Growing recurring revenues and focused investments Collaboration: Across innovation ecosystem of pharma, biotech and academia, drives our business forward Translational Research and Data Science: Key to accelerating development and ensuring the right therapies get to the right patients Research Track record of success and investing for tomorrow Development Scaling up capabilities to expand from early- to late-stage development Commercialization Building the next step in our evolution Enabling Functions: Supporting growth and managing risk |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag015.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;15 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** Inspired by Nature At Genmab, we are inspired by nature and understand how antibodies work. We are deeply knowledgeable about antibody biology and our scientists harness this expertise to create and develop differentiated investigational antibody medicines. We utilize a sophisticated and highly automated process to efficiently generate, select, produce and evaluate human antibody-based products. Our teams have established a fully inte-grated R&D enterprise and streamlined process to coordinate the activities of antibody product discovery, pre-clinical testing, manufacturing, clinical trial design and execution, and regulatory submissions across Genmab's international oper-ations. Through our expertise in antibody drug development, we pioneer technologies that allow us to create differentiated and potentially first-in-class or best-in-class investigational medicines with the potential to improve patients' lives. Our antibody expertise has enabled us to create our cutting-edge technology platforms: DuoBody, HexaBody, DuoHexaBody® and HexElect®. To connect patients with the right medicine at the right dose, we are also transforming Genmab; building on our world-class research in antibodies to expand our capabilities beyond the lab. We have expanded our scientific focus to use data science and artificial intelligence to aid in the discovery of new targets and biomarkers and bolster our in-depth translational medicine labo-ratory capabilities. Sustainable and State-of-the-Art Facilities The Netherlands Genmab's discovery and pre-clinical research is conducted at our R&D Center in Utrecht, the Netherlands, one of the first Building Research Establishment Environmental Assessment Method (BREEAM) Excellent laboratory buildings in the Netherlands. The R&D Center is located in close proximity to other life sciences companies and a world-class research university. It houses state-of-the-art laboratories including an advanced robotics lab, a modern auditorium, science café, and innovative brainstorming and meeting rooms. The space provides a bright, open and collabo-rative atmosphere to enable the Genmab team to continue to innovate and find new ways to help patients. To accommodate Genmab's growth, we will occupy most of the new "Accelerator" multi-tenant building, connected directly to the Genmab R&D Center. It is designed to achieve the same BREEAM Excellent high sustainability standard. Expansion into this building, which will contain both offices and laboratories, is expected in 2023. Research and Development Capabilities United States Genmab opened its new U.S. facility in 2020. This space, modeled on the open and collabora-tive spirit of the R&D Center in Utrecht, includes both offices and laboratories. The U.S. transla-tional research laboratories allow Genmab to expand our translational pre-clinical and clinical drug development research expertise and are part of the strategic growth of the Company. As with the construction and design of our Utrecht facilities, our U.S. office and laboratories were designed and built with sustainability in mind and meet the requirements for Leadership in Energy and Environmental Design (LEED) Gold certifica-tion for sustainable design features. Additionally, 75% of the construction waste created when building out the facility was recycled, rather than being sent to a landfill. As Genmab continues to grow our geographical footprint, we will endeavor to do so with minimal impact to the environment and with sustainability as a key area of focus. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag016.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Financial Statements Other Information **Table of Contents** Management's Review 16 Genmab \| 2022 Annual Report \| Management's Review Enhancing Commercialization Capabilities to Bring Our Innovations to Patients Our 2030 Vision is for Genmab's KYSO antibody medicines to fundamentally transform the treatment of cancer and other serious diseases. We are becoming an integrated end-to-end biotech innovation powerhouse that discovers, develops, and delivers next-generation antibody-based medicines to patients. Through the addition of key talent and the purposeful and strategic growth of our capabilities, we have never been in a better position to achieve our Vision. Key to our ability to bring our medicines to patients is commercialization. Over the past few years, we have made tremendous progress in building and establishing this important capability, first in the U.S. and Japan, through a disciplined and integrated approach. • In the third quarter of 2021, together with our partner Seagen, we launched our first marketed medicine, Tivdak, in the U.S. Since its launch, Tivdak is on the way to becoming the clear second-line choice for women with recurrent or metastatic cervical cancer with more than 900 women estimated to have received treatment as of December 2022. • We continue to expand our capabilities as we prepare for the potential launch of epcoritamab in the U.S. and Japan, pending regulatory approvals, by deepening our talent base, focusing on impactful approaches and optimal access for all appropriate patients. • Our commercialization team is anchored in highly experienced leaders and teams across functions: medical affairs, marketing, market access, insights and analytics as well as field-based teams in the U.S. to ensure the best possible experience for care teams and their patients treated with our medicines. • We have built a global commercial team to help shape our development and go-to-market strategy in close partnership with R&D. Building a deep understanding of the potential and evolution of markets/segments will help ensure a thoughtful approach to advancing our pipeline. At Genmab, commercialization is an integrated approach guided by our commitment to the patients we serve; everyone doing their part to ensure patients get the most from our next-generation differentiated antibody-based medicines. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag017.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;17 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** We are experts in antibody discovery and development. Our appreciation for, and understanding of, the power of the human immune system gives us a unique perspective on how to respond to the constant challenges of oncology drug development. We entered a new chapter with the commercialization and launch of our first medicine, co-owned with Seagen, in 2021, and we are preparing for the potential launch of our second medicine in 2023 under our collaboration with AbbVie. Antibody Discovery and Development Target Antibody Format Indication T1/2 Antibody-Drug Conjugate/ Immunocytokine Designer Polyclonals/ Bispecifics Half-Life Extended/Inert/ Fc-Enhanced/Isotypes |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag019.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;19 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** Products and Technologies Genmab's Proprietary1 Products Approved Medicine Approved Product Target Developed By Disease Indication Tivdak (tisotumab vedotin-tftv) Tissue factor (TF) Co-development Genmab/Seagen Adult patients with recurrent or metastatic cervical cancer with disease progression on or after chemotherapy2 1. Approved and investigational medicines where Genmab has ≥50% ownership, in co-development with partners as indicated. 2. Refer to local country prescribing information for precise indication and safety information. Pipeline, Including Further Development for Approved Medicine Product Target Developed By Disease Indications Most Advanced Development Phase Pre-clinical 1 1/2 2 3 Tisotumab vedotin TF Co-development Genmab/Seagen Cervical cancer Solid tumors Epcoritamab CD3, CD20 Co-development Genmab/AbbVie Relapsed/refractory DLBCL Relapsed/refractory FL (combo) B-cell non-Hodgkin lymphoma (B-NHL) B-NHL (combo) Relapsed/refractory chronic lymphocytic leukemia (CLL) & Richter's Syndrome Indolent NHL, pediatric patients DuoBody-PD-L1x4-1BB (GEN1046/BNT311) PD-L1, 4-1BB Co-development Genmab/BioNTech Non-small cell lung cancer (NSCLC) Solid tumors Duo8ody-CD40x4-1 BB (GEN1042/BNT312) CD40, 4-1BB Co-development Genmab/BioNTech Solid tumors DuoHexaBody-CD37 (GEN3009) CD37 Genmab1 Hematologic malignancies HexaBody-CD38 (GEN3014) CD38 Genmab2 Hematologic malignancies DuoBody-CD3xB7H4 (GEN1047) CD3, B7H4 Genmab Solid tumors HexaBody-CD27 (GEN1053/BNT313) CD27 Co-development Genmab/BioNTech Solid tumors GEN1056 (BNT322) Undisclosed Co-development Genmab/BioNTech Solid tumors 1. In June 2022, AbbVie decided to discontinue co-development of DuoHexaBody-CD37. Upon expiry of the 180-day notice period on December 24, 2022, Genmab became solely responsible for the further development of DuoHexaBody-CD37 against low-single digit royalty payments to AbbVie, up to an agreed maximum total royalty amount, based on future potential sales of the product. 2. Genmab is developing HexaBody-CD38 in an exclusive worldwide license and option agreement with Janssen. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag021.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;21 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** Genmab's Proprietary Pipeline Programs where Genmab has ≥50% ownership. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag022.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;22 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review protease-cleavable linker that covalently attaches the microtubule-disrupting agent monomethyl auristatin E to the antibody. Genmab used tech - nology licensed from Medarex to generate the TF antibody forming part of tisotumab vedotin. Tisotumab vedotin, marketed as Tivdak, is the first and only U.S. FDA approved ADC for the treatment of adult patients with recurrent or meta - static cervical cancer with disease progression on or after chemotherapy. Tisotumab vedotin is being co-developed by Genmab and Seagen. Under a joint commercialization agreement, Genmab is co-promoting Tivdak in the U.S. and will lead commercial operational activities in Japan. Seagen is leading commercial operational activities in the U.S. and will lead commercial operational activities in Europe and China. In these four markets there will be a 50:50 cost and profit split. In other markets, Seagen will commer - cialize Tivdak and Genmab will receive royalties based on a percentage of aggregate net sales ranging from the mid-teens to the mid-twenties. The companies have joint decision-making on the worldwide development and commercialization strategy for Tivdak. Please refer to Note 5.6 of the financial statements for further details regarding the tisotumab vedotin collaboration with Seagen. The companies have a broad clinical development program for tisotumab vedotin, including a confir - matory Phase 3 study in recurrent or metastatic cervical cancer. Please consult the U.S. Prescribing Information for Tivdak for the labeled indication and safety information, including the boxed warning. First and Only U.S. FDA Approved Antibody-drug Conjugate (ADC) for Recurrent or Metastatic Cervical Cancer • An ADC directed to TF, a protein highly prevalent on solid tumors, including cervical cancer, which is associated with poor prognosis • Accelerated approval granted by the U.S. FDA for Tivdak, the first and only approved ADC for the treatment of adult patients with recurrent or metastatic cervical cancer with disease progression on or after chemotherapy • U.S. FDA approval was based on data from the innovaTV 204 (NCT03438396) Phase 2 single-arm clinical study evaluating tisotumab vedotin as monotherapy in patients with previously treated recurrent or metastatic cervical cancer • In addition to a Phase 3 study in recurrent or metastatic cervical cancer (innovaTV 301, NCT04697628), clinical studies in other solid tumors are ongoing • Co-developed globally and co-promoted in the U.S. in collaboration with Seagen Tisotumab vedotin is an ADC composed of Genmab's human monoclonal antibody directed to TF and Seagen's ADC technology that utilizes a Tivdak (tisotumab vedotin-tftv) Genmab's Proprietary Pipeline |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag023.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;23 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** Genmab's Proprietary Pipeline Key Ongoing Clinical Trials Disease Stage Development Phase Pre-clinical 1 1/2 2 3 Cervical cancer Recurrent or metastatic innovaTV 301 Recurrent or Stage IVB (Combo & Mono) innovaTV 205 Solid tumors Locally advanced or metastatic innovaTV 207 About Cervical Cancer1 • Cancer that originates in the cells lining the cervix • Fourth most frequently diagnosed and fourth most deadly cancer in women worldwide2 • In developing regions, ranked second in incidence and mortality in women2 • In 2022, an estimated 14,100 new cases of invasive cervical cancer will be diagnosed, and 4,280 women will die from the disease in the U.S.3 • Up to 16% of women initially present with metastatic cervical cancer3 • Among women who present with earlier stage disease, 15%–61% will go on to develop metastatic cervical cancer, most commonly within the first two years following completion of therapy4 • 5-year survival rate for women in the U.S. and Japan with recurrent or metastatic cervical cancer is only 17.1% and 19.5%, respectively, highlighting an urgent unmet need for effective treatment3 1. General statistics include all stages of cervical cancer. 2. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians. 2018;68(6):394-424. 3. Institute NC. SEER Cancer Stat Facts: Cervical Cancer. 2022. https://seer.cancer.gov/statfacts/html/ cervix.html. Accessed November 21, 2022. 4. Pfaendler KS, Tewari KS. Changing paradigms in the systemic treatment of advanced cervical cancer. Am J Obstet Gynecol. 2016;214(1):22-30. Updates from First Quarter to Third Quarter • June: Genmab and Seagen presented multiple tisotumab vedotin abstracts at the American Society of Clinical Oncology (ASCO) Annual Meeting, including interim data from the Phase 1b/2 innovaTV 205 (NCT03786081) study of tisotumab vedotin, which was presented during an oral session. The ongoing innovaTV 205 study is evaluating tisotumab vedotin as monotherapy and in combination with other agents in recurrent or metastatic cervical cancer. • March: Genmab and Seagen presented interim data from two cohorts of the Phase 1b/2 innovaTV 205 study of tisotumab vedotin as a virtual oral presentation at the Society of Gynecologic Oncology Annual Meeting on Women's Cancer. • February: Genmab and Seagen presented preliminary data from the Phase 2 innovaTV 207 (NCT03485209) study of tisotumab vedotin as part of a plenary session at the American Society for Radiation Oncology (ASTRO) 2022 Multidisciplinary Head and Neck Cancers Symposium. The ongoing innovaTV 207 study is evaluating the activity, safety and tolerability of tisotumab vedotin in selected solid tumors with high TF expression. The data presented at ASTRO was from the squamous cell carcinoma of the head and neck (SCCHN) cohort of the study, which is evaluating tisotumab vedotin as monotherapy in patients with SCCHN who experienced disease progression on or after a first-line platinum-containing regimen and a checkpoint inhibitor. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag024.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;24 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Genmab's Proprietary Pipeline Epcoritamab (DuoBody-CD3xCD20) Potential Best-in-Class Investigational Medicine • Bispecific antibody-based investigational medicine created with Genmab's DuoBody technology • Multiple ongoing clinical studies across different settings and histologies, including Phase 3 studies in DLBCL (EPCORE DLBCL-1, NCT04628494) and FL (EPCORE FL-1, NCT05409066) with more studies in planning • In the second half of 2022, Genmab submitted a BLA to the U.S. FDA and a Japan New Drug Application (JNDA) to the Ministry of Health, Labor and Welfare (MHLW) in Japan for SC epcoritamab for the treatment of patients with relapsed/ refractory LBCL. AbbVie submitted an MAA to the EMA for SC epcoritamab for the treatment of patients with relapsed/refractory DLBCL. The BLA was subsequently accepted for Priority Review by the U.S. FDA and the MAA was validated by the EMA. The U.S. FDA set a PDUFA date of May 21, 2023 • The regulatory submissions were supported by results from the LBCL cohort of the pivotal EPCORE NHL-1 (NCT03625037) trial evaluating the safety and preliminary efficacy of epcoritamab in patients with relapsed, progressive or refractory CD20+ mature B-NHL, including DLBCL • Co-developed in collaboration with AbbVie Epcoritamab is a proprietary bispecific antibody created using Genmab's DuoBody technology platform. Epcoritamab targets CD3, which is expressed on T-cells, and CD20, a clinically validated target on malignant B-cells. Genmab used technology licensed from Medarex to generate the CD20 antibody forming part of epcoritamab. In 2020, Genmab entered into a broad oncology collaboration agreement with AbbVie to jointly develop and commercialize epcoritamab. The companies will share commer - cial responsibilities in the U.S. and Japan, with AbbVie responsible for further global commercial - ization. Genmab will book sales in the U.S. and Japan and receive tiered royalties on remaining global sales outside of these territories. Please refer to Note 5.6 of the financial statements for further details regarding the epcoritamab collab - oration with AbbVie. The companies have a broad clinical development program for epcoritamab, including two Phase 3 studies ongoing, and addi - tional studies in planning. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag025.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;25 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** Genmab's Proprietary Pipeline Key Ongoing Clinical Trials Disease Stage Development Phase Pre-clinical 1 1/2 2 3 DLBCL Relapsed/Refractory EPCORE DLBCL-1 FL Relapsed/Refractory (Combo) EPCORE FL-1 B-NHL Relapsed/Progressive/Refractory EPCORE NHL-1 Relapsed/Progressive/Refractory (Japan) EPCORE NHL-3 Relapsed/Refractory Pediatric EPCORE Peds-1 Previously Untreated/Relapsed/Refractory (Combo) EPCORE NHL-2 Previously Untreated/Relapsed/Refractory (China) EPCORE NHL-4 Previously Untreated/Relapsed/Refractory (Combo) EPCORE NHL-5 CLL/Richter's Syndrome Relapsed/Refractory EPCORE CLL-1 About Diffuse Large B-cell Lymphoma • DLBCL is an aggressive type of NHL that develops from B cells1 • DLBCL is the most common type of NHL in the U.S. and worldwide1 • Prognosis for relapsed or refractory DLBCL patients is poor, especially for those with high-risk factors3 • For most patients with refractory DLBCL there are no curative treatment options3 1. Lymphoma Research Foundation. Diffuse Large B-Cell Lymphoma. https://lymphoma.org/ understanding-lymphoma/aboutlymphoma/nhl/ dlbcl/ Accessed December 2, 2022. 2. National Institutes of Health. SEER Cancer Stat Facts: DLBCL. https://seer.cancer.gov/statfacts/html/ dlbcl.html. Accessed November 21, 2022. 3. Crump, Michael, et al. "Outcomes in Refractory Diffuse Large B-Cell Lymphoma: Results from the International SCHOLAR-1 Study." Blood, American Society of Hematology, 19 Oct. 2017, https://www. ncbi.nlm.nih.gov/pmc/articles/PMC5649550/. Fourth Quarter Updates • December: Publication in the Journal of Clinical Oncology, "Epcoritamab, a Novel, Subcutaneous CD3xCD20 Bispecific T-Cell–Engaging Antibody, in Relapsed or Refractory Large B-Cell Lymphoma: Dose Expansion in a Phase I/II Trial." • December: Genmab submitted to the MHLW a JNDA for SC epcoritamab for the treatment of patients with relapsed/refractory LBCL after two or more lines of systemic therapy. • December: Multiple presentations at the 64th American Society of Hematology (ASH) Annual Meeting, including four oral presentations. • November: The U.S. FDA accepted the BLA for SC epcoritamab for Priority Review. The U.S. FDA set a PDUFA date of May 21, 2023. Based on Genmab's agreement with AbbVie this event triggered a milestone payment of USD 80 million to Genmab. • October: AbbVie submitted an MAA to the EMA for SC epcoritamab for the treatment of patients with relapsed/refractory DLBCL after two or more lines of systemic therapy. This was subsequently validated by the EMA, an event that triggered a milestone payment of USD 60 million to Genmab. Updates from First Quarter to Third Quarter • September: Genmab submitted a BLA to the U.S. FDA for SC epcoritamab for the treatment of patients with relapsed/refractory LBCL after two or more lines of systemic therapy. • June: Genmab and AbbVie presented multiple epcoritamab abstracts at both the ASCO Annual Meeting and the 27th Annual Meeting of the European Hematology Association (EHA). Data from the first cohort of the EPCORE NHL-1 trial of epcoritamab in relapsed/refractory LBCL was presented as a late-breaking oral presentation during the Presidential Symposium at EHA. • April: Genmab and AbbVie announced topline results from the first cohort of the Phase 1/2 EPCORE NHL-1 trial of epcoritamab in relapsed/ refractory LBCL. • March: The U.S. FDA granted orphan-drug designation to epcoritamab for the treatment of FL. 64.6% 5-year survival rate2 |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag026.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;26 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review DuoBody-PD-L1x4-1BB (GEN1046/BNT311) DuoBody-CD40x4-1BB (GEN1042/BNT312) Bispecific Next-Generation Immunotherapy • Bispecific antibody-based investigational medicine created with Genmab's DuoBody technology platform • Clinical studies in solid tumors ongoing, including a Phase 2 study in NSCLC (NCT05117242) • Co-developed in collaboration with BioNTech Potential First-in-Class Bispecific Agonistic Antibody • Bispecific antibody-based investigational medicine created with Genmab's DuoBody technology platform • Phase 1/2 clinical study (NCT04083599) in solid tumors ongoing • Co-developed in collaboration with BioNTech DuoBody-PD-L1x4-1BB is a proprietary bispecific antibody, jointly owned by Genmab and BioNTech, created using Genmab's DuoBody technology platform. It is being co-developed by Genmab and BioNTech under an agreement in which the companies share all costs and future potential profits for DuoBody-PD-L1x4-1BB on a 50:50 basis. DuoBody-PD-L1x4-1BB is designed to induce an antitumor immune response by simul-taneous and complementary PD-L1 blockade and conditional 4-1BB stimulation using an inert DuoBody format. Three clinical studies in solid tumors are ongoing including a Phase 2 study of DuoBody-PD-L1x4-1BB as monotherapy or in combination with pembrolizumab in patients with recurrent metastatic NSCLC. DuoBody-CD40x4-1BB is a proprietary bispecific antibody, jointly owned by Genmab and BioNTech, created using Genmab's DuoBody technology platform. It is being co-developed by Genmab and BioNTech under an agreement in which the companies share all costs and future potential profits for DuoBody-CD40x4-1BB on a 50:50 basis. CD40 and 4-1BB were selected as targets to enhance both dendritic cells and antigen-de-pendent T-cell activation, using an inert DuoBody format. A Phase 1/2 clinical study of DuoBody-CD40x4-1BB in solid tumors is ongoing. Fourth Quarter Update • December: Combination safety data and early encouraging anti-tumor activity in SCCHN patients treated with chemotherapy, pembrolizumab and DuoBody-CD40x4-1BB was presented at the European Society for Medical Oncology Immuno-Oncology Annual Congress. Genmab's Proprietary Pipeline |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag027.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;27 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** DuoHexaBody-CD37 (GEN3009) HexaBody-CD38 (GEN3014) First DuoHexaBody Program in Clinical Development • Antibody-based investigational medicine created with Genmab's DuoHexaBody technology platform • Phase 1/2 clinical study (NCT04358458) in hematologic malignancies ongoing HexaBody-based Investigational Medicine with Potential in Hematological Malignancies • Antibody-based investigational medicine created with Genmab's HexaBody technology platform • Phase 1/2 clinical study (NCT04824794) in hematological malignancies ongoing • Developed in an exclusive worldwide license and option agreement with Janssen DuoHexaBody-CD37 is a bispecific antibody that targets two non-overlapping CD37 epitopes, created using Genmab's DuoHexaBody technology platform. The DuoHexaBody technology platform combines the dual targeting of our DuoBody tech-nology platform with the enhanced potency of our HexaBody technology platform, creating bispe-cific antibodies with target-mediated enhanced hexamerization. A Phase 1/2 clinical study in hematologic malignancies, including the potential for combination with epcoritamab, is ongoing. Update from First Quarter to Third Quarter • June: AbbVie decided to discontinue co-development of DuoHexaBody-CD37. Upon expiry of the 180-day notice period on December 24, 2022, Genmab became solely responsible for the further development of DuoHexaBody-CD37 against low-single digit royalty payments to AbbVie, up to an agreed maximum total royalty amount, based on future potential sales of the product. HexaBody-CD38 is a human CD38 monoclonal antibody-based investigational medicine created using Genmab's HexaBody technology platform. In pre-clinical models of hematological malig-nancies, HexaBody-CD38 demonstrated highly potent complement-dependent cytotoxicity and showed potent anti-tumor activity. In June 2019, Genmab entered into an exclusive worldwide license and option agreement with Janssen to develop and commercialize HexaBody-CD38. A Phase 1/2 clinical study in hematologic malignan-cies is ongoing and includes an arm comparing HexaBody-CD38 to daratumumab in anti-CD38 monoclonal antibody-naïve relapsed or refractory multiple myeloma patients. Fourth Quarter Update • December: Poster presentation of preliminary dose-escalation results presented at the 64th ASH Annual Meeting. Genmab's Proprietary Pipeline |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag028.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;28 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review DuoBody-CD3xB7H4 (GEN1047) HexaBody-CD27 (GEN1053/BNT313) Bispecific with Potential in Solid Tumors • Bispecific antibody-based investigational medicine created with Genmab's DuoBody technology platform • Phase 1/2 clinical study (NCT05180474) in malignant solid tumors ongoing HexaBody-based Investigational Medicine with Potential in Solid Tumors • Antibody-based investigational medicine created with Genmab's HexaBody technology platform • Phase 1/2 clinical study (NCT05435339) in solid tumors ongoing • Co-developed in collaboration with BioNTech HexaBody-CD27 is a CD27 antibody that utilizes Genmab's HexaBody technology, specifically engineered to form an antibody hexamer (a formation of six antibodies) upon binding its target on the cell membrane of T cells. It is being co-developed by Genmab and BioNTech under an agreement in which the companies share all costs and future potential profits for HexaBody-CD27 on a 50:50 basis. A Phase 1/2 clinical study of HexaBody-CD27 in solid tumors is ongoing. DuoBody-CD3xB7H4 is a bispecific anti-body-based investigational medicine created using Genmab's DuoBody technology platform. B7H4 is an immune checkpoint protein expressed on malignant cells in various solid cancers including breast, ovarian and lung cancer. In pre-clinical studies, DuoBody-CD3xB7H4 induced T-cell mediated cytotoxicity of B7H4-positive tumor cells. DuoBody-CD3xB7H4 is being developed for the potential treatment of solid cancer indications known to express B7H4. A Phase 1/2 clinical study of DuoBody-CD3xB7H4 in malignant solid tumors is ongoing. Update from First Quarter to Third Quarter • January: The first patient was dosed in the first-in-human Phase 1/2 study of DuoBody-CD3xB7H4 in patients with malignant solid tumors. Fourth Quarter Updates • November: The first patient was dosed in the first-in-human Phase 1/2 study of HexaBody-CD27 in patients with malignant solid tumors. • November: First pre-clinical disclosure during the Society for Immunotherapy of Cancer 37th Annual Meeting. Update from First Quarter to Third Quarter • May: IND application and first Clinical Trial Application (CTA) submitted for HexaBody-CD27. Genmab's Proprietary Pipeline |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag029.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;29 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** GEN1056 (BNT322) First-in-Human Study Recruiting • Phase 1 clinical study (NCT05586321) in solid tumors ongoing • Co-developed in collaboration with BioNTech GEN1056 is an antibody product being co-developed by Genmab and BioNTech for the treatment of solid tumors and for use in combi-nation with other products. A first-in-human Phase 1 clinical study of GEN1056 in patients with advanced solid tumors is ongoing. Fourth Quarter Update • November: The first patient was dosed in the first-in-human Phase 1 study of GEN1056. Update from First Quarter to Third Quarter • July: The first CTA was submitted for GEN1056. Genmab's Proprietary Pipeline |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag030.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;30 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Pre-clinical Programs • Broad pre-clinical pipeline that includes both partnered products and in-house programs based on our proprietary technologies and/or antibodies • Multiple new INDs expected to be submitted over the coming years • Genmab has entered multiple strategic collaborations to support the expansion of our innovative pipeline Our pre-clinical pipeline includes immune effector function enhanced antibodies developed with our HexaBody technology platform and bispecific antibodies created with our DuoBody technology platform. We are also collaborating with our partners to generate additional new antibody-based product concepts. A number of the pre-clinical programs are conducted in coop-eration with our collaboration partners. Update from First Quarter to Third Quarter • August: Genmab and BioNTech expanded the companies' global strategic collaboration to develop and commercialize novel immunotherapies for the treatment of cancer patients. Under the expansion, the companies will jointly develop and commercialize, subject to regulatory approval, other formats including monospecific antibodies leveraging Genmab's proprietary HexaBody technology platform. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag032.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;32 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Approved Medicines Incorporating Genmab's Innovations and Technology Daratumumab is a human monoclonal antibody that binds with high affinity to the CD38 molecule, which is highly expressed on the surface of multiple myeloma cells and is also expressed by AL amyloidosis plasma cells. Genmab used technology licensed from Medarex to generate the CD38 antibody. Daratumumab is being developed by Janssen under an exclusive worldwide license from Genmab to develop, manufacture and commercialize daratumumab. Under the terms of the agreement, Genmab is entitled to double digit royalties between 12% and 20% with Janssen reducing such royalty payments for Genmab's share of Janssen's royalty payments made to Halozyme. Please refer to Note 5.6 of the financial statements for further details regarding the daratumumab collaboration with Janssen. Daratumumab (marketed as DARZALEX for IV administration and as DARZALEX FASPRO in the U.S. and as DARZALEX SC in Europe for SC administration) is approved in a large number of territories for the treatment of adult patients with certain multiple myeloma indications and is the only approved therapy in the U.S., Europe and Japan for the treatment of adult patients with AL amyloidosis. Please consult the European Summary of Product Characteristics for DARZALEX and DARZALEX SC and the U.S. Prescribing Information for DARZALEX and DARZALEX FASPRO for the labeled indication and safety information. Redefining the Treatment of Multiple Myeloma • First-in-class human CD38 monoclonal antibody • Developed and commercialized by Janssen under an exclusive worldwide license from Genmab • Intravenous (IV) formulation approved in combination with other therapies and as monotherapy for certain multiple myeloma indications • First and only SC CD38-directed antibody approved for the treatment of certain multiple myeloma indications, known as DARZALEX FASPRO in the U.S., and as DARZALEX SC in Europe • SC daratumumab is the first and only approved therapy for AL amyloidosis in the U.S., Europe and Japan • 2022 net sales of DARZALEX by Janssen were USD 7,977 million |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag033.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;33 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** Approved Medicines Incorporating Genmab's Innovations and Technology Ofatumumab is a human monoclonal antibody that targets an epitope on the CD20 molecule encompassing parts of the small and large extra-cellular loops. Genmab used technology licensed from Medarex to generate the CD20 antibody. Ofatumumab, marketed as Kesimpta, is approved in territories including the U.S., Europe and Japan for the treatment of certain adult patients with RMS. Kesimpta is the first B-cell therapy that can be self-administered by patients at home or anywhere using the Sensoready autoin-jector pen, once monthly after starting therapy. Ofatumumab is being developed and marketed worldwide by Novartis under a license agreement between Genmab and Novartis. Under the terms of the agreement, Genmab is entitled to 10% royalties on net sales of Kesimpta. Please refer to Note 5.6 of the financial statements for further details regarding the ofatumumab collaboration with Novartis. Please consult the U.S. Prescribing Information and the European Summary of Product Characteristics for the labeled indication and safety information for Kesimpta. Approved in the Treatment of RMS • Human CD20 monoclonal antibody developed and commercialized by Novartis under a license agreement with Genmab • Approved in territories including the U.S., EU and Japan for treatment of RMS in adults • First B-cell therapy that can be self-administered by patients at home or anywhere using the Sensoready® autoinjector pen |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag035.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;35 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** Approved Medicines Incorporating Genmab's Innovations and Technology In July 2012, Genmab entered into a collaboration with Janssen to create and develop bispecific antibodies using Genmab's DuoBody technology platform. One of these, Janssen's amivantamab, is a fully human bispecific antibody that targets epidermal growth factor receptor (EGFR) and cMet, two validated cancer targets. The two antibody libraries used to produce amivantamab were both generated by Genmab. In collaboration with Janssen, the antibody pair used to create amivantamab was selected. Janssen is respon-sible for the development and commercialization of amivantamab. In 2021, Janssen received approvals in the U.S., Europe and other markets for amivantamab, marketed as RYBREVANT, for the treatment of certain adult patients with NSCLC with EGFR exon 20 insertion mutations. These were the first regu-latory approvals for a therapy that was created using Genmab's proprietary DuoBody bispecific technology platform. Under our agreement with Janssen, Genmab will receive milestones and royalties between 8% and 10% on net sales of RYBREVANT. Please refer to Note 5.6 of the financial statements for further details regarding the DuoBody collaboration with Jansen. Please consult the U.S. Prescribing Information and the European Summary of Product Characteristics for RYBREVANT for the labeled indication and safety information. First Regulatory Approvals for a DuoBody-based Medicine • Part of Genmab and Janssen DuoBody research and license agreement • First approved medicine created using Genmab's proprietary DuoBody technology platform • Under the agreement with Janssen, Genmab will receive milestones and royalties on net sales of RYBREVANT |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag036.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;36 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Approved Medicines Incorporating Genmab's Innovations and Technology In July 2012, Genmab entered into a collaboration with Janssen to create and develop bispecific antibodies using Genmab's DuoBody technology platform. One of the products subsequently discovered and developed by Janssen is teclis-tamab, a bispecific antibody that targets CD3, which is expressed on T-cells and B-cell matu-ration antigen (BCMA), which is expressed on mature B lymphocytes. In August 2022, Janssen received conditional marketing authorization from the European Commission for subcutaneously administered teclistamab, marketed as TECVAYLI, as mono-therapy for the treatment of adult patients with relapsed and refractory multiple myeloma. Patients must have received at least three prior therapies, including an immunomodulatory agent, a proteasome inhibitor, and a CD38 antibody and have demonstrated disease progression on the last therapy. In October 2022, Janssen received U.S. FDA approval of TECVAYLI™ (teclistam-ab-cqyv) for the treatment of adult patients with relapsed or refractory multiple myeloma, who previously received four or more prior lines of therapy, including a proteasome inhibitor, immu-nomodulatory drug and anti-CD38 monoclonal antibody. TECVAYLI is the second therapy created using Genmab's proprietary DuoBody bispecific tech-nology platform to receive regulatory approval. Under our agreement with Janssen, Genmab will receive milestones and a mid-single digit royalty on net sales of TECVAYLI. Please refer to Note 5.6 Bispecific Antibody Approved for the Treatment of Relapsed and Refractory Multiple Myeloma • Part of Genmab and Janssen DuoBody research and license agreement • Second approved medicine created using Genmab's proprietary DuoBody technology platform • Under the agreement with Janssen, Genmab will receive milestones and royalties on net sales of TECVAYLI of the financial statements for further details regarding the DuoBody collaboration with Jansen. Please consult the U.S. Prescribing Information and the European Summary of Product Characteristics for TECVAYLI for the labeled indi-cation and safety information. (teclistamab) TECVAYLI TM |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag037.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;37 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** Antibody Technologies Our Proprietary Technology Platform Suite Platform Principle Applications DuoBody Bispecific antibodies Dual-targeting: • Recruitment (e.g., T cells) • Tumor heterogeneity HexaBody Target-mediated enhanced hexamerization Enhanced potency: • Complement-dependent cytotoxicity (CDC) • Target clustering, outside-in signaling, apoptosis DuoHexaBody Bispecific antibodies with target-mediated enhanced hexamerization Dual-targeting + enhanced potency: • CDC • Target clustering, outside-in signaling, apoptosis HexElect Two co-dependent anti-bodies with target-mediated enhanced hexamerization Dual-targeting + enhanced potency and selectivity: • Co-dependent unlocking of potency • New target space, previously inaccessible Antibodies are Y-shaped proteins that play a central role in immunity against bacteria and viruses (also known as pathogens). As we develop immunity, our bodies generate antibodies that bind to pathogen structures (known as antigens), which are specific to the pathogen. Once bound, the antibodies attract other parts of the immune system to eliminate the pathogen. In modern medicine, we have learned how to create and develop specific antibodies against antigens associated with diseased human cells for use in the treatment of diseases such as cancer and autoimmune disease. Genmab uses several types of technologies to create antibodies to treat disease and has developed proprietary antibody technologies including the DuoBody, HexaBody, DuoHexaBody and HexElect technology platforms. Information about these technolo-gies can be found in the following sections and at www.genmab.com/research-innovation/ antibody-technology-platforms/. We use or license several other technologies to generate diverse libraries of high-quality, functional antibodies. In addition, we use or license technologies to increase the potency of some of our antibody therapeutics on a product-by-product basis, including ADCs. ADCs are antibodies with potent cytotoxic agents coupled to them. By using antibodies that recognize specific targets on tumor cells, these cytotoxic agents are preferentially delivered to the tumor cells. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag038.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;38 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review DuoBody Technology Platform Antibody Technologies The DuoBody technology platform is Genmab's innovative platform for the discovery and devel-opment of bispecific antibodies. Bispecific antibodies bind to two different epitopes (or "docking" sites) either on the same or on different targets (also known as dual-targeting). Dual-targeting may improve binding specificity and enhance therapeutic efficacy or bring two different cells together (for example, engaging a T cell to kill a tumor cell). Bispecific antibodies generated with the DuoBody technology platform can be used for the development of therapeutics for diseases such as cancer, autoimmune, infec-tious, cardiovascular, central nervous system diseases and hemophilia. DuoBody molecules combine the benefits of bispecificity with the strengths of conventional antibodies, which allows DuoBody molecules to be administered and dosed the same way as other antibody thera-peutics. Genmab's DuoBody technology platform generates bispecific antibodies via a versatile and broadly applicable process that is easily performed at high throughput, standard bench, as well as at commercial manufacturing scale. Genmab uses the DuoBody technology platform to create its own bispecific antibody programs and the technology is also available for licensing. Genmab has numerous alliances for the DuoBody Innovative Technology for Bispecific Antibody Therapeutics • Bispecific antibody technology platform • Potential in cancer, autoimmune, infectious, cardiovascular, central nervous system diseases and hemophilia • Commercial collaborations with AbbVie, Janssen and BioNTech among others, plus multiple research collaborations • First regulatory approvals for medicines created using the DuoBody technology platform—Janssen's RYBREVANT and TECVAYLI • In the second half of 2022, Genmab submitted a BLA to the U.S. FDA and a JNDA to the MHLW for SC epcoritamab for the treatment of patients with relapsed/refractory LBCL. AbbVie submitted an MAA to the EMA for SC epcoritamab for the treatment of patients with relapsed/refractory DLBCL The innovative DuoBody technology platform generates bispecific antibodies via a fast, versatile and broadly appli-cable process called controlled Fab-arm exchange. With only minimal protein engineering, the technology allows the binding arms of two distinct monoclonal antibodies to exchange, combining into one stable bispecific antibody, thereby retaining regular immunoglobulin structure and function. The DuoBody technology platform is also highly suitable for high throughput generation, screening and discovery of bispecific antibodies in final therapeutic format. technology platform including commercial collab-orations with AbbVie, Janssen, Novo Nordisk, BioNTech and Immatics. Genmab's proprietary DuoBody technology platform has been applied to a variety of bispe-cific antibody products in development, both in our own pipeline and in programs being developed by collaboration partners. The tech-nology has been validated by the continued advancement of these investigational medicines through clinical development, including two medicines approved in both the U.S. and in Europe. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag039.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;39 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** Advancing Our Pipeline AbbVie On June 10, 2020, Genmab entered into a broad oncology collaboration agreement with AbbVie to jointly develop and commercialize products including epcoritamab (DuoBody-CD3xCD20), and subsequently into a discovery research collaboration for up to four future differentiated antibody therapeutics for cancer. The companies will share commercial responsibilities for epcoritamab in the U.S. and Japan, with AbbVie responsible for further global commercialization. Genmab will be the principal for net sales in the U.S. and Japan and will receive tiered royalties on remaining global sales outside of these territories. For any product candidates developed as a result of the companies' discovery research collaboration, Genmab and AbbVie will share responsibilities for global development and commercialization in the U.S. and Japan. Genmab retains the right to co-commercialize these products, along with AbbVie, outside of the U.S. and Japan. Antibody Technologies DuoBody Collaborations Under the terms of the agreement, Genmab has the potential to receive regulatory and sales milestone payments, as well as tiered royalties between 22% and 26% on net sales for epcoritamab outside the U.S. and Japan. Except for these royalty-bearing sales, the parties will share in pre-tax profits from the potential sale of epcoritamab on a 50:50 basis. If all four next-generation antibody product candidates developed as a result of the discovery research collaboration are successful, Genmab is eligible to receive up to USD 2.0 billion in option exercise and success-based milestones. Genmab and AbbVie split 50:50 the development costs related to epcoritamab, while Genmab will be responsible for 100% of the costs for the discovery research programs up to opt-in. Please refer to Note 5.6 of the financial statements for further details regarding the collaboration with AbbVie. BioNTech In May 2015, Genmab entered an agreement with BioNTech to jointly research, develop and commercialize bispecific antibody-based inves-tigational medicines using Genmab's DuoBody technology platform. Under the terms of the agreement, BioNTech will provide proprietary antibodies against key immunomodulatory targets, while Genmab provides proprietary anti-bodies and access to its DuoBody technology platform. Genmab paid an upfront fee of USD 10 million to BioNTech. If the companies jointly select any antibody-based product candidates for clinical development, development costs and product ownership will be shared equally going forward. If one of the companies does not wish to move an antibody product forward, the other company is entitled to continue devel-oping it on predetermined licensing terms. The agreement also includes provisions which will allow the parties to opt out of joint development at key points. Genmab and BioNTech selected two antibody products for clinical development, DuoBody-CD40x4-1BB (GEN1042/BNT312) and DuoBody-PD-L1x4-1BB (GEN1046/BNT311), both of which are now in clinical trials. Our Innovative Technology in Action Janssen In July 2012, Genmab entered into a collaboration with Janssen to create and develop bispecific anti-bodies using our DuoBody technology platform. Under this original agreement, Janssen had the right to use the DuoBody technology platform to create panels of bispecific antibodies (up to 10 DuoBody programs) to multiple disease target combinations. As of December 31, 2022, three DuoBody-based investigational medicines created under this collaboration were in the clinic. Two of these, amivantamab and teclistamab, are the first medicines created using the DuoBody tech-nology platform to receive regulatory approval. In December 2022, Janssen submitted a BLA to the U.S. FDA for the third investigational medicine in active clinical development, talquetamab, for the treatment of patients with relapsed or refractory multiple myeloma. Genmab is entitled to milestone payments as well as royalties on sales of each commercialized DuoBody medicine. Please refer to Note 5.6 of the financial state-ments for further details regarding the DuoBody collaboration with Janssen. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag040.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;40 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Antibody Technologies Novo Nordisk In August 2015, Genmab entered an agreement to grant Novo Nordisk commercial licenses to use the DuoBody technology platform to create and develop bispecific antibody candidates for two therapeutic programs that would target a disease area outside of cancer therapeutics. After an initial period of exclusivity for both target combi-nations, Novo Nordisk extended exclusivity of the commercial license for one target combination in 2018, now in clinical development as Mim8. Under the exclusive license agreement, Genmab is entitled to potential milestones and will be entitled to single digit royalties on sales of Mim8, should it receive regulatory approval. Collaborations Across the Pharma and Biotech Ecosystem Immatics In July 2018, Genmab entered into a research collaboration and exclusive license agreement with Immatics to discover and develop next-gen-eration bispecific immunotherapies to target multiple cancer indications. Genmab received an exclusive license to three proprietary targets from Immatics, with an option to license up to two additional targets at predetermined economics. Under the terms of the agreement, Genmab paid Immatics an upfront fee of USD 54 million and Immatics is eligible to receive up to USD 550 million in development, regulatory and commercial milestone payments for each antibody product, as well as tiered royalties on net sales. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag041.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;41 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** HexaBody Technology Platform The HexaBody technology platform is a propri-etary Genmab technology that is designed to increase the potency of antibodies. The HexaBody technology platform builds on natural biology and strengthens the natural killing ability of antibodies while retaining regular structure and specificity. The technology allows for the creation of potent therapeutics by inducing antibody hexamer formation (clusters of six antibodies) after binding to their target antigen on the cell surface. We have used the HexaBody technology platform to generate antibodies with enhanced complement-mediated killing, allowing antibodies with limited or absent killing capacity to be transformed into potent, cytotoxic antibodies. In addition to complement-mediated killing, the clustering of membrane receptors by the HexaBody technology platform can lead to subsequent outside-in signaling leading to cell death. The HexaBody technology platform creates opportunities to explore new antibody-based product candidates and repurpose drug candi-dates unsuccessful in previous clinical trials due to insufficient potency. The HexaBody tech-nology platform is broadly applicable and can be combined with Genmab's DuoBody technology platform (DuoHexaBody technology platform) as well as other antibody technologies. The technology has the potential to enhance antibody therapeutics for a broad range of applications including cancer and infectious diseases. Genmab is using the HexaBody technology platform for its own antibody programs and the technology is also available for licensing. Two HexaBody-based investigational medicines are currently in clinical development. Genmab entered into an exclusive worldwide license and option agreement with Janssen to develop and commercialize Creating Differentiated Therapeutics • Enhanced potency antibody technology platform • Broadly applicable technology that builds on natural antibody biology • HexaBody-based investigational medicines in clinical development; HexaBody-CD38 (GEN3014) and HexaBody-CD27 (GEN1053/BNT313) Antibody Technologies HexaBody-CD38 (GEN3014), a next-generation CD38 monoclonal antibody-based investiga-tional medicine. In 2022, Genmab and BioNTech expanded their global strategic collaboration to include co-development of monospecific antibody candidates leveraging the HexaBody technology. The first antibody in the clinic under this collabo-ration is HexaBody-CD27 (GEN1053/BNT313). |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag042.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;42 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review DuoHexaBody Technology Platform HexElect Technology Platform The DuoHexaBody technology platform is a proprietary technology that combines the dual targeting of our DuoBody technology platform with the enhanced potency of our HexaBody tech-nology platform, creating bispecific antibodies with target-mediated enhanced hexamerization. We currently have one investigational medicine created with the DuoHexaBody technology platform in the clinic, DuoHexaBody-CD37 (GEN3009). DuoHexaBody-CD37 is a bispecific antibody that targets two non-overlapping CD37 epitopes. It entered the clinic in 2020 and is currently being investigated in relapsed/refrac-tory B-NHL, including potentially in combination with epcoritamab. The HexElect antibody technology platform is Genmab's newest proprietary antibody tech-nology. This technology combines two HexaBody molecules designed to effectively and selectively hit only those cells that express both targets by making the activity of complexes of HexaBody molecules dependent on their binding to two different targets on the same cell. The HexElect technology platform maximizes efficacy while minimizing possible toxicity, potentially leading to more potent and safer investigational medicines. Combining Dual-Targeting and Enhanced Potency • Antibody technology that combines DuoBody and HexaBody technology platforms • Creates bispecific antibodies with target-mediated enhanced potency • First DuoHexaBody-based investigational medicine in the clinic— DuoHexaBody-CD37 (GEN3009) Enhancing Selectivity and Potency • Antibody technology platform inspired by the HexaBody technology platform • Combines dual-targeting with enhanced selectivity and potency Antibody Technologies |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag043.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;43 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** Corporate Social Responsibility and Sustainability Commitments We are committed to being a sustainable, socially responsible biotech company. This commitment is anchored in our vision, core purpose and values, focused for impact through our CSR strategy, and lived every day by our team. It is fundamental to the way we do business. Our Core Purpose and Vision Our commitment to CSR is anchored in our company's core purpose "to improve the lives of patients by creating and developing innovative antibody products" and our vision that "by 2030, our KYSO antibody medicines will fundamentally transform the lives of people with cancer and other serious diseases." Our vision inspires and motivates us. Our unstoppable team is focused on developing innovative and differentiated antibody therapeutics that will improve the lives of patients. How We Carry Out Our CSR Initiatives We are committed to complying with all laws, codes, and standards applicable to our business and operations. We also prioritize the well-being and vitality of our teams and actively seek to minimize our impact on the environment. We have high ethical standards and aim to conduct business with companies and within countries that share our ethical commitment including our support for the protection of internationally proclaimed human rights. We strive to conduct clinical trials in markets where a medicine is planned to become available. We track trends, benchmark and examine our ESG activities, policies and disclosures to build a sustainable, socially responsible biotech company. We are committed to transparency and continued improvement of our climate disclosures. To this end, we support the TCFD recommendations as we believe they provide a useful framework to increase transparency on climate-related risks and opportunities. We want to reduce our envi-ronmental footprint and aim to provide additional disclosures on climate-related topics in the future as we incorporate the TCFD recommendations into our business. Please refer to "Genmab's Task Force on Climate-related Financial Disclosures" in this report for more information. We follow the Sustainability Accounting Standards Board (SASB) framework to disclose critical measurements on ESG activities relevant to our business. Our Approach Our approach is designed to ensure we carry out our CSR commitments as a core part of our business and in line with international best practice. • Guided by our vision, purpose and core values • Focused on four CSR pillars • Underpinned by our commitment to the UNSDGs • Supported by the Board of Directors and Executive Management • Aligned with ESG priorities and disclosures CSR Governance Our CSR governance is led by the Board of Directors. Our Board of Directors' Nominating and Corporate Governance Committee oversees our CSR efforts and provides recommendations to the Board on corporate responsibility and sustainability matters. Additionally, the Board of Directors' Audit and Finance Committee oversees our ESG reporting requirements. Our CSR Committee, which is co-chaired by our CEO and the Senior Vice President of Global Communications and Corporate Affairs, provides direction on CSR strategy and associated policies and ensures we carry out our CSR activities effec-tively and communicate them clearly and openly. Our CSR Global Council and Global Sustainability Working Group help us implement and enhance our CSR strategy. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag044.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;44 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Corporate Social Responsibility and Sustainability Commitments We are committed to ensuring our actions benefit our direct stakeholders (patients, customers, team members, collaboration partners and shareholders) and society as a whole. To this end, our CSR strategy focuses on four key pillars: Science-Driven Health Innovations for Patients Employee Well-Being and Vitality Ethics and Transparency Environmental and Community Sustainability 1 We use our world-class knowledge in antibody biology and deep expertise in innovative antibody technology to develop cancer treatments to have a positive impact on society. 2 We care for our employees' health, well-being, safety and development and promote a collabo-rative culture that fosters passion for innovation, integrity and respect. 3 We believe that DE&I are fundamental to achieving our vision and are committed to cham-pioning a corporate culture that accepts and promotes uniqueness and empowers each team member to bring their authentic self to work in a safe, open and respectful environment. 4 We operate our business with the utmost integrity, seeking to do the right thing in all aspects of our business and integrating compli-ance, ethics and transparency into our business practices, policies and procedures. 5 We maintain a highly ethical organization, promoting our Code of Conduct to employees and engaging with partners and suppliers committed to the same level of ethics in their operations. 6 We aim to reduce our impact on the environment by refining our processes and incorporating best practices into our operations as we strive to reduce our environmental footprint, minimize waste and decrease use of hazardous material. 7 We monitor and evaluate targets for ESG activities, measure our impact and communicate our progress. 8 We engage with and support the communities in which we operate. As we further execute our CSR strategy and build programs that have an impact on our stakeholders, we will be guided by the following tenets, which support our four CSR pillars: |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag045.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;45 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** Corporate Social Responsibility and Sustainability Commitments Our Commitment to the United Nations Sustainable Development Goals As a company rooted in science, inspired by patients, and committed to sustainability, we embrace our responsibility to society and are proud to help advance the UNSDGs. An initial internal assessment in 2020 determined that our business activities were most closely aligned with Goals 3, 5 and 8. In 2022, based on our commit - ment and actions regarding climate change, we decided to add Goal 13: Climate Action. We focus on aligning our CSR activities to support these goals and will continue to assess our business operations in relation to all the UNSDGs. Goal 3: Good Health and Well-Being: Ensure healthy lives and promote well-being for all at all ages We are dedicated to using science-driven innovation to improve the lives of patients with cancer and their families. In addition to dedicating resources to research and development and to bring medicines to patients, we are committed to our employees' well-being and vitality, and have benefits and programs in place for them. Additionally, we seek to support and be part of health-related initiatives in the communities where we operate. Goal 5: Gender Equality: Achieve gender equality and empower all women and girls We continue to lead in gender diversity among our peers. We have a female representation at "Director-level and above" of 51% and are proud that nearly half of our Board of Directors are female, including the Chair and Deputy Chair. Genmab's statutory report on Corporate Responsibility for the financial year 2022 cf. Sections 99a, 99b, 99d and 107d of the Danish Financial Statements Act ("Lovpligtig redegørelse for samfundsansvar, jf. årsregnskabslovens § 99 a, 99b, 99d, 107d") can be found on the company's website (https:// ir.genmab.com/static-files/72218610-90a6-4fd3-a76a-d4a7c9c6ef01), including additional information about policies, progress made during 2022 and expected activities for 2023. Goal 8: Decent Work and Economic Growth: Promote sustained, inclusive and sustain - able economic growth, full and productive employment and decent work for all Our work is driven by innovation and conducted by highly skilled people dedicated to their roles. We pay all our team members a living wage and provide a safe, inclusive and secure working environment. Additionally, we contribute to the life sciences innovation ecosystem by collaborating with academia, biotech and pharma companies, and other innovators to advance therapies against cancer and other diseases. We also contribute to science, technology, engineering, and mathematics (STEM) education, mentoring programs and other community efforts to help advance education and professional development among our communities. Goal 13: Climate Action: Take urgent action to combat climate change and its impacts We are committed to transparency and continued improvement of our climate disclosures. In 2022, we committed to supporting the recommendations of the TCFD. Our journey to reduce our impact on the environment inspired our work to establish a climate target to reduce our GHG emissions in line with the Paris Agreement to align our business to a future where global warming is kept at or below 1.5°C. We measure and report on emissions from our own oper - ations and from purchased electricity and have begun the process of designing a model to collect data across our value chain for our Scope 3 emissions. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag046.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;46 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Genmab's Task Force on Climate-related Financial Disclosures Topic Recommended Disclosures Genmab's Disclosures Governance Describe the board's oversight of climate-related risks and opportunities. The Board of Directors' Nominating and Corporate Governance Committee oversees climate-related issues as part of its responsibility over all aspects of Genmab's CSR strategy. The Committee and the Board of Directors receive biannual updates on Genmab's progress, related risks and opportunities. Describe management's role in assessing and managing climate-related risks and opportunities. The CSR Committee moves our CSR efforts forward and integrates ESG-related matters relevant to our business into our strategic planning. From 2022, the CSR Committee will receive updates on Genmab's progress toward carbon reduction targets, climate-related financial risk, relevant prevention and mitigation measures annually. Climate-related financial risks and relevant prevention and mitigation measures will be reviewed and endorsed by the Global Compliance and Risk Committee. Additionally, the Audit and Finance Committee oversees our ESG reporting requirements. Strategy Describe the climate-related risks and opportunities the organization has identified over the short, medium and long term. Describe the impact of climate-related risks and opportunities on the organization's businesses, strategy and financial planning. Genmab has conducted scenario analysis on the potential transition and physical risks and opportunities related to climate change, at 1.5–2°C and 4°C of warming, across our value chain, in the short term (2030), and medium/long term (2040/2050). Below is a brief summary of the key potential risks identified: Description of potential risks identified 1.5–2°C, short term: ― Transition risk resulting from emerging certification, regulation and carbon taxation, pricing, and tariffs and related costs of compliance and the switch to low carbon materials and technologies ― Transition risk resulting from increased focus of investors and regulators on ESG performance in investment decision-making, increasingly connecting access to capital and investment to ESG and climate performance ― Transition risk resulting from shift in consumer preferences and talent attraction criteria toward climate and responsibility ― Physical risk of disruption of supply chains due to changes in weather patterns and extreme weather events ― Physical risk resulting from more frequent and severe heat waves, leading to increased cooling costs Description of potential risks identified 1.5–2°C, medium/long term ― Physical risk of disruption of supply chains and operations due to changes in weather patterns and increase in frequency of extreme weather events ― Physical risk resulting from more frequent and severe heat waves, leading to increased cooling costs ― Physical risk resulting from coastal flooding, potentially disrupting operations and the supply chain Description of potential risks identified 4°C, short term ― Physical risk of disruption of supply chains, acute limited supply, and increased cost of raw materials due to changes in weather patterns and extreme weather events ― Physical risk resulting from frequent and severe heat waves, leading to increased cooling costs ― Physical risk of disruption of supply chain, operations and distribution, resulting from increased acute flooding |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag047.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;47 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** Genmab's Task Force on Climate-related Financial Disclosures (TCFD) Topic Recommended Disclosures Genmab's Disclosures Strategy (continued) Describe the climate-related risks and opportunities the organization has identified over the short, medium and long term. Describe the impact of climate-related risks and opportunities on the organization's businesses, strategy and financial planning. Description of potential risks identified 4°C, medium/long term ― Transition risk resulting from fragmented regulatory efforts to curb runaway climate change through cost of compliance with carbon taxation, pricing, etc. ― Physical risk resulting from acute, severe and frequent extreme weather events, leading to disruption of operations, supply chain and distribution, damage to physical assets and inventory, as well as increase in raw materials cost and insurance costs ― Physical risk resulting from acute and severe heat waves, leading to instability of supply chains, increased energy costs for cooling and loss of inventory ― Physical risk resulting from sea level rise and coastal flooding, leading to disruption of operations and supply chains, damage to physical assets, inventory Describe the climate-related risks and opportunities the organization has identified over the short, medium and long term. Describe the impact of climate-related risks and opportunities on the organization's businesses, strategy and financial planning. Brief summary of the key potential climate-related opportunities: Description of potential opportunities identified 1.5–2°C and 4°C ― Cost savings from the use of new technologies, more energy efficient/low carbon production and distribution ― Cost savings and reduced exposure to resource and water scarcity through, for instance, the use of recycling ― Increase resilience, adaptation and cost savings from efficient and green buildings ― Cost savings and lowered exposure to carbon pricing and other regulations ― Reputational gains with stakeholders and potential employees from focus on climate-related topics Describe the impact of climate-related risks and opportunities on the organization's businesses, strategy and financial planning. Climate-related risks and opportunities identified will be considered and integrated as part of Genmab's ERM program, financial planning and strategy. To play our part in mitigating the physical impacts of climate change and curbing warming, Genmab will commit to a climate target, to reduce our GHG emissions in line with the Paris Agreement. Describe the resilience of the organization's strategy, taking into consideration different climate-related scenarios, including a 2°C or lower scenario. Genmab has conducted qualitative climate-related scenario analysis. Four scenarios spanning 1.5–2°C and 4°C of warming were developed based on Intergovernmental Panel on Climate Change, International Energy Agency and other sources, and Genmab's risks and opportunities across the value chain in the short, medium/long term were assessed. In 2023, Genmab will further assess the resilience of our corporate strategy in these climate-related scenarios. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag048.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;48 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Genmab's Task Force on Climate-related Financial Disclosures (TCFD) Topic Recommended Disclosures Genmab's Disclosures Risk Management Describe the organization's processes for identifying and assessing climate-related risks. In 2022, Genmab continued its assessment of climate-related risk and scenario analysis to identify key risks and opportunities. The risks have been assessed through stakeholder engagement and interviews. Describe the organization's processes for managing climate-related risks. Climate-related risks identified will be considered as part of our ERM program, and responsibility for monitoring, prevention and mitigation will be cascaded to relevant functions within Genmab. Describe how processes for identifying, assessing and managing climate-related risks are integrated into the organization's overall risk management. Metrics and Targets Disclose the metrics used by the organization to assess climate-related risks and opportunities in line with its strategy and risk management process. Genmab reports on Scope 1 and 2 GHG emissions in line with the GHG Protocol. Genmab will develop metrics related to business continuity and natural disaster recovery. These may include, for instance, suppliers assessed/engaged on climate and climate risk topics, etc. Disclose Scope 1, Scope 2 and, if appropriate, Scope 3 GHG emissions and the related risks. Genmab's Scope 1 and 2 emissions totaled 393.8 tonnes CO2e in 2022. Emissions reductions will contribute to the mitigation of the transition risk of carbon taxes, pricing and tariffs. In connection with our intent to commit to and set a climate target, Genmab started the process of measuring our Scope 3 emissions by estimating emissions from selected material Scope 3 categories. This estimation will be foundational in establishing the baseline for our climate ambitions, targets and emissions reductions. Describe the targets used by the organization to manage climate-related risks and opportunities and performance against targets. Genmab intends to commit to and set a climate target to reduce our GHG emissions in line with the Paris Agreement goals. We calculated our Scope 1 and 2 emissions in accordance with the global standard for carbon accounting, the GHG Protocol, and these were reduced by 38% compared to 2021. In 2022 we initiated the process of estimating our Scope 3 footprint in accordance with the GHG Protocol. A thorough assessment of Genmab's value chain emissions based on 2021 spend-data showed us that there is a need for higher quality data. This is due to our business model, where key carbon intensive process steps for the discovery and development of our antibody-based molecules are outsourced, and a majority of revenue is generated based on royalty streams from out-licensed products. The 2022 assessment had an unacceptable uncertainty level with regards to >90% of our estimated emissions. We will continue to improve the quality of our data and we will strive to engage with our suppliers and partners in order to obtain a Scope 3 carbon footprint with an acceptable level of accuracy, acknowledging that carbon footprint mapping is inherently uncertain. Carbon Emissions 2022 Total Scope 1 emissions (tCO2e) 283.1 Total Scope 2 emissions (tCO2e) 110.7 Total Scope 1 & 2 emissions (tCO2 e) 393.8 Electricity Consumption and Renewables 2022 Electricity consumption (MWh) 3,127 Share renewables 94% |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag049.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;49 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** Stakeholder Engagement As an international company, Genmab has many stakeholders with an interest in how we conduct our business. Continuous engagement with these groups drives our success. We do this through direct interactions, participation in industry groups, employee engagement surveys, and more. Some of Genmab's key stakeholder groups and the ways we interact with them are highlighted here. Our Research Collaborators Genmab collaborates with parties from large pharmaceutical companies to academic institutions. These are collaborations with complementary partners in terms of technologies, capabilities and knowledge. Why are they important to us? Collaborations across the innovation ecosystem of pharma, biotech and academia help us create innovative next-generation antibody therapeutics and potentially bring them to patients faster. How do we engage with them? Our methods of engagement vary from co-development of programs, licensing of our technology platforms, involvement in clinical trials and indirectly, through our work with industry groups. Our list of research collaborations is extensive. We work with large pharmaceutical and biotechnology companies as well as other inno-vative companies and groups. Some examples of the latter include: Tempus, which has built one of the world's largest libraries of clinical and molecular data; the European Network of Gynecological Oncological Trial Groups and Gynecologic Oncology Group, with which we collaborated on the tisotumab vedotin innovaTV 204 study; industry groups such as the Biotechnology Innovation Organization (BIO), Holland Bio, BioNJ and the Confederation of Danish Industry. Our People The health, well-being, safety, and development of Genmab's team members is a top priority for the organization. Why are they important to us? Our talented teams are the cornerstone of our success and funda-mental to achieving our 2030 Vision. We believe that an engaged, inclusive and diverse workplace inspires our employees and is essential to our future. How do we engage with them? Genmab aims to foster individual empowerment and development and allows people to transform their skills into real value for patients. In 2022, we conducted a global team member engagement survey, which consisted of both questionnaire and focus groups on five topics: Camaraderie & Teamwork, Career Development, Empowerment & Trust, Performance Management and Work-Life Balance. Genmab's results outpaced Life Sciences industry bench-marks and highlighted key opportunities to drive even higher engagement in the future. The survey had an 88% global participa-tion rate and an 84% employee engagement score. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag050.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;50 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Patient Advocacy Organizations With our first medicine on the market, we have an obligation to engage with patient advocates to ensure we are providing as much support as possible to patients in need. Why are they important to us? Transforming the lives of patients is our purpose. Supporting and collaborating with patient advocacy organizations is an important way in which Genmab can positively impact the lives of patients. How do we engage with them? Over the course of the past few years, we have actively sought out patient advocacy groups, both to provide our financial support for their efforts and programs and also to collaborate and bring them to our locations for educational events with the Genmab team. In 2022 we, along with our partner Seagen, launched CeMe, a disease awareness campaign that leverages real-life storytelling to spotlight the barriers to treatment and challenges associated with cervical cancer. The campaign features diverse members of the cervical cancer community, including patients and patient advocates, in content on the CeMe YouTube channel. Social media posts encourage visits to the YouTube channel to watch the videos and seek additional information from various patient advocacy groups. Our Communities Our team members actively engage in the communities in which we operate. Why are they important to us? As part of Genmab's ongoing commitment to CSR we aim to be good citizens not only of the world but of the local communities in which our facilities are located. How do we engage with them? Throughout 2022, Genmab supported community-based activ-ities; for example, on September 13, 2022, nearly 500 Genmab colleagues participated in the first annual Global Volunteer Day. Colleagues from Denmark, the Netherlands and the U.S. helped more than 30 nonprofit organizations in their communi-ties. Activities included: removing invasive plants from a nature preserve, building toys for children with serious illnesses, making comfort kits for cancer patients, and assembling food kits to combat hunger in our local communities. Colleagues can also use the Community@Genmab Portal to learn about Genmab's impact, share volunteer stories, and access the Global Employee Giving Program. Our Shareholders and Investors Genmab has a diverse shareholder base with investors from across a spectrum of size and location. Why are they important to us? The support of Genmab's investors is essential to the success of the Company as we grow into a fully integrated biotech innovation powerhouse. How do we engage with them? We communicate about our business, financial results, develop-ment programs and scientific results in an open and transparent way through company announcements, investor meetings and company presentations. Illustrating this transparency, we maintain a dialogue with our shareholders, investors and other stakeholders, and the Board of Directors participates in ad hoc investor meetings, e.g., as part of regular corporate governance outreach campaigns to our share-holders, as well as their representatives and proxy advisors, to gain insight into the perspective of our shareholders. More information on Genmab's stakeholder engage-ment may be found in our 2022 Corporate Responsibility Report on the company's website (https://ir.genmab.com/ static-files/72218610-90a6-4fd3-a76a-d4a7c9c6ef01). Stakeholder Engagement |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag051.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;51 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** Human Capital Management Employees are Genmab's most important resource, and we strive to attract and retain the most qualified people to fulfill our core purpose. Genmab's goal is to develop and retain value in our own products which could one day transform cancer treatment. At Genmab, we have four culture pillars that inspire team members in their everyday work. Teamwork and respect are central pillars of Genmab's culture, and we therefore ensure an inclusive, open and supportive professional work environment across our international locations. We believe that fostering workplace diversity across social, educational, cultural, national, age and gender lines is a prerequisite for the continued success of the company. We are committed to diversity at all levels of the company and strive to recruit employees with the right skills and competencies, regardless of gender, age, ethnicity and other differences. Skill, knowledge, experience and employee motivation are essential to Genmab as a biotech company. The ability to organize our highly skilled and very experienced colleagues at all levels of the organization into interactive teams is a key factor in achieving our goals and ensuring Genmab's success. Key Employee Information Male/Female Ratios 2022 2021 Male Female Male Female Genmab Group 42% 58% 42% 58% Director level and above 49% 51% 49% 51% Below director level 37% 63% 38% 62% Annual promotions1 40% 60% 39% 61% Other Employee Information 2022 2021 FTE at the end of the year 1,660 1,212 Research and development FTE 1,193 927 Selling, general and administrative FTE 467 285 FTE in Denmark at the end of the year 385 312 FTE in the Netherlands at the end of the year 575 437 FTE in the US at the end of the year 642 420 FTE in Japan at the end of the year 58 43 Employee turnover2 7% 6% Employee absence3 2% 2% 1. Annual promotions are calculated as FTE promotions occurring during the respective years. 2. Employee turnover percentage is calculated by the FTE voluntarily leaving since the beginning of the year divided by the average FTE. 3. The rate of absence is measured as absence due to the employee's own illness, pregnancy-related sick leave and occupational injuries and illnesses compared with a regional standard average of working days in the year, adjusted for holidays. Genmab's Culture Pillars We are 'One Genmab' We respect and celebrate our differences while working as One Team Rooted in Science We hypothesize and experiment to seek innovative solutions, no matter our role Patients Come First We are committed to making a positive impact for patients Act with Courage We speak up, empower each other, and embrace change and grow |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag052.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Financial Statements Other Information **Table of Contents** Management's Review 52 Genmab \| 2022 Annual Report \| Management's Review Financial Review Anthony Pagano Executive Vice President and Chief Financial Officer As we look back at 2022, the strength of Genmab's financial profile really stands out. Our strong balance sheet, growing recurring revenues and significant underlying profitability have allowed us, and will continue to allow us, to strategically invest in our business and our pipeline. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag053.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;53 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** The financial statements are prepared on a consolidated basis for Genmab A/S (parent company) and its subsidiaries. The Genmab financial statements are published in Danish Kroner (DKK). The Genmab consolidated Group is referenced herein as "Genmab" or the "Company". Result for the Year Guidance and Result for 2022 (DKK million) Latest Guidance Actual Revenue 13,500–14,500 14,595 Operating expenses (8000)–(8400) (8238) Operating profit 5,100–6,500 6,357 Actual revenue was favorable to guidance primarily due to higher than anticipated milestone revenue and slightly favorable USD/DKK foreign exchange rate movements. Operating expenses and operating profit were in line with the latest guidance published on November 9, 2022. Revenue Genmab's revenue was DKK 14,595 million in 2022 compared to DKK 8,482 million in 2021. The increase of DKK 6,113 million, or 72%, was primarily driven by higher DARZALEX and Kesimpta royalties achieved under our collabora-tions with Janssen and Novartis, respectively, due to higher net sales and higher average exchange rate between the USD and DKK, and milestones achieved in 2022 under our collaboration with AbbVie. Financial Review Split of 2022 Revenue (DKK million) Split of 2021 Revenue (DKK million) Royalties 80% (11672) Milestone Revenue 12% (1767) Reimbursement Revenue 6% (818) Collaboration Revenue 2% (332) License Revenue <1% (6) Royalties 82% (6977) Milestone Revenue 11% (954) Reimbursement Revenue 6% (531) Collaboration Revenue <1% (20) Royalties Royalty revenue amounted to DKK 11,672 million in 2022 compared to DKK 6,977 million in 2021. The increase of DKK 4,695 million, or 67%, was primarily driven by higher DARZALEX, Kesimpta and TEPEZZA royalties achieved under our daratu-mumab collaboration with Janssen, ofatumumab collaboration with Novartis, and teprotumumab collaboration with Roche, respectively. The following table summarizes Genmab's royalty revenue by product. (DKK million) 2022 2021 DARZALEX 10,056 6,135 TEPEZZA 796 593 Kesimpta 779 235 Other 41 14 Total royalties 11,672 6,977 Net sales of DARZALEX by Janssen were USD 7,977 million in 2022 compared to USD 6,023 million in 2021. The increase of USD 1,954 million, or 32%, was driven by share gains, continued strong market growth and uptake of the DARZALEX SC product. Royalty revenue on net sales of DARZALEX was DKK 10,056 million in 2022 compared to DKK 6,135 million in 2021, an increase of DKK 3,921 million. The percentage increase in royalties of 64% is higher than the percentage increase in the underlying net sales primarily due to the higher average exchange rate between the USD and DKK, other positive foreign exchange rate impacts, and a higher effective royalty rate for 2022, partly offset by the increase in Genmab's share of Janssen's royalty payments to Halozyme in connection with SC product net sales. Under our license agreement with Janssen for DARZALEX, for purposes of calculating royalties due to Genmab, DARZALEX net sales for non-U.S. dollar denominated currencies are trans-lated to U.S. dollars at a specified annual Currency Hedge Rate. This contractual arrangement is the driver for the other foreign exchange impacts discussed above. 14,595 2022 Total Revenue 8,482 2021 Total Revenue |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag054.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;54 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Royalty revenue on net sales of TEPEZZA was DKK 796 million in 2022 compared to DKK 593 million in 2021, an increase of DKK 203 million, or 34%. TEPEZZA net sales in the first quarter of 2021 were negatively impacted by the U.S. government-man-dated COVID-19 production interruption. Net sales of Kesimpta by Novartis were USD 1,092 million in 2022 compared to USD 372 million in 2021. The increase of USD 720 million was driven by strong launch uptake, access and increased demand. Royalty revenue on net sales of Kesimpta was DKK 779 million in 2022 compared to DKK 235 million in 2021, an increase of DKK 544 million. Janssen was granted U.S. FDA approval for RYBREVANT during the second quarter of 2021, and Genmab subsequently started recognizing royalties on net sales of RYBREVANT. Royalties were not material for 2022 or 2021. Janssen was granted approval for TECVAYLI for the treatment of relapsed or refractory multiple myeloma during the third quarter of 2022 in Europe and in the fourth quarter of 2022 in the U.S. Royalties were not material for 2022. Royalty revenue fluctuations from period to period are driven by the level of product net sales, foreign currency exchange rate movements and more specifically to DARZALEX, the contractual arrangement related to annual Currency Hedge Rate, and Genmab's share of Janssen's royalty payments to Halozyme in connection with SC product net sales. Reimbursement Revenue Reimbursement revenue, mainly comprised of the reimbursement of certain research and development costs related to the development work under Genmab's collaboration agreements, amounted to DKK 818 million in 2022 compared to DKK 531 million in 2021. The increase of DKK 287 million, or 54%, was primarily driven by higher activities under our collaboration agree-ments with BioNTech for HexaBody-CD27 and DuoBody-CD40x4-1BB. Milestone Revenue Milestone revenue was DKK 1,767 million in 2022 compared to DKK 954 million in 2021, an increase of DKK 813 million, or 85%, primarily driven by the following: • AbbVie milestone of DKK 577 million (USD 80 million) driven by the acceptance of the BLA by the U.S. FDA for epcoritamab, • AbbVie milestone of DKK 444 million (USD 60 million) triggered by the validation of the MAA by the EMA in the EU for epcoritamab, • Janssen milestones of DKK 189 million (USD 25 million) and DKK 112 million (USD 15 million) for the approval of TECVAYLI for the treatment of relapsed or refractory multiple myeloma in the U.S. and Europe, respectively, and • AbbVie milestone of DKK 153 million (USD 20 million) driven by the initiation, or first patient dosed, of a pivotal trial (Phase 3) in the second indication for epcoritamab. The increase in milestone revenue in 2022 was partly offset by milestones achieved in 2021 under our Janssen and AbbVie collaborations. Milestone revenue may fluctuate significantly from period to period due to both the timing of achievements and the varying amount of each individual milestone under our license and collab-oration agreements. Collaboration Revenue In September 2021, Genmab and Seagen announced U.S. FDA accelerated approval for Tivdak in previously treated recurrent or meta-static cervical cancer. Collaboration revenue was DKK 332 million in 2022 compared to DKK 20 million in 2021. The increase of DKK 312 million was primarily driven by increased sales of Tivdak and also includes a one-off payment due from Seagen of DKK 112 million (approximately USD 15 million) which reflects Genmab's share (50%) of payments received by Seagen in connection with the sublicense of its rights to develop and commercialize tisotumab vedotin in China to Zai Lab Hong Kong pursuant to Genmab's Joint Commercialization Agreement with Seagen. Refer to Note 2.1 for further details about revenue. Operating Expenses Total operating expenses increased by DKK 2,774 million, or 51%, from DKK 5,464 million in 2021 to DKK 8,238 million in 2022. Research and Development Expenses Research and development expenses amounted to DKK 5,562 million in 2022 compared to DKK 4,181 million in 2021. The increase of DKK 1,381 million, or 33% was driven by the continued advancement of our product pipeline including epcoritamab under our collaboration with AbbVie, and DuoBody-CD40x4-1BB under our collaboration with BioNTech, and the increase in team members to support the expansion of our product pipeline. Research and development costs accounted for 68% of the total operating expenses in 2022 compared to 77% in 2021. Financial Review |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag055.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;55 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** The following table provides information regarding our research and development expenses for 2022 as compared to 2021. (DKK million) 2022 2021 Percentage Change 2022/2021 Research1 1,222 958 28% Development and contract manufacturing2 1,556 1,374 13% Clinical3 2,059 1,360 51% Upfront payments4 155 61 154% Other5 570 428 33% Total research and development expenses 5,562 4,181 33% 1. Research expenses include, among other things, personnel, occupancy and laboratory expenses, technology access fees associated with identification of new monoclonal antibodies (mAbs), expenses associated with the development of new proprietary technologies and research activities associated with our product candidates, such as in vitro and in vivo studies, translational research, and IND enabling toxicology studies. 2. Development and contract manufacturing expenses include personnel and occupancy expenses, external contract manufac-turing costs for the scaleup and pre-approval manufacturing of drug product used in research and our clinical trials, costs for drug product supplied to our collaborators, costs related to preparation for the production of process validation batches to be used in potential future regulatory submissions, quality control and assurance activities, and storage and shipment of our product candidates. 3. Clinical expenses include personnel, travel, occupancy costs, and external clinical trial costs including contract research organi-zations (CROs), investigator fees, clinical site fees, contractors and regulatory activities associated with conducting human clinical trials. 4. Upfront payments include payments made to third parties upon entering into R&D license and collaboration agreements. 5. Other research and development expenses primarily include share-based compensation, depreciation, amortization and impairment expenses. The following table shows third-party costs incurred for research, contract manufacturing of our product candidates and clinical and regulatory services for 2022 as compared to 2021. The table also presents unallocated costs and overhead consisting of third-party costs for our pre-clinical stage programs, personnel, facilities and other indirect costs not directly charged to development programs. (DKK million) 2022 2021 Percentage Change 2022/2021 Epcoritamab 1,115 654 70% Tisotumab vedotin 319 365 (13)% DuoBody-PD-L1x4-1BB 369 371 (1)% DuoBody-CD40x4-1BB 242 135 79% Other clinical stage programs 419 250 68% Total third-party costs for clinical stage programs 2,464 1,775 39% Pre-clinical projects 830 779 7% Upfront payments 155 61 154% Personnel, unallocated costs and overhead 2,113 1,566 35% Total research and development expenses 5,562 4,181 33% Third-party costs for epcoritamab increased by DKK 461 million, or 70%, in 2022 as compared to 2021, primarily due to the advancement of the program to late-stage development under Genmab's collaboration with AbbVie. Third-party costs for tisotumab vedotin decreased by DKK 46 million, or 13%, in 2022 as compared to 2021, primarily due to the completion of some clinical studies in 2022. Third-party costs for DuoBody-PD-L1x4-1BB remained flat in 2022 compared to 2021 as development of this program continues under Genmab's collaboration with BioNTech. Third-party costs for DuoBody-CD40x4-1BB increased by DKK 107 million, or 79%, in 2022 as compared to 2021, primarily due to the continued advancement and expansion of the program under Genmab's collaboration with BioNTech. Third-party costs for Genmab's other clinical stage programs increased by DKK 169 million, or 68%, in 2022 as compared to 2021, primarily related to HexaBody-CD27, DuoBody-CD3xB7H4 and GEN1056 entering the clinical stage in 2022. Financial Review |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag056.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;56 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Research and development expenses related to our pre-clinical projects increased by DKK 51 million, or 7%, in 2022 as compared to 2021, driven by the continued investment in and number of pre-clinical programs. Upfront payments increased by DKK 94 million, or 154%, driven by an increase in the number of R&D license payments in 2022 as compared to 2021. Personnel, unallocated costs and overhead increased by DKK 547 million, or 35%, in 2022 as compared to 2021, primarily due to an increase in staffing levels and the expansion of our facilities to accommodate our growth. Our research and development FTEs increased from 927 at the end of 2021 to 1,193 at the end of 2022. Selling, General and Administrative Expenses Selling, general and administrative expenses were DKK 2,676 million in 2022 compared to DKK 1,283 million in 2021. The increase of DKK 1,393 million, or 109%, was driven by the increase in team members to support Tivdak post launch, continued expansion of Genmab's commercialization capabilities in support of future launches including the potential launch of epcor-itamab, and investment in broader organizational infrastructure, including our technology portfolio. DKK 1,065 million, or 40% of selling, general and administrative expenses in 2022, was related to compensation of Genmab team members involved in selling, general and administrative activities, as compared to DKK 529 million, or 41% in 2021. Selling, general and administrative expenses accounted for 32% of the total operating expenses in 2022 compared to 23% in 2021. Operating Profit Operating profit was DKK 6,357 million in 2022 compared to DKK 3,018 million in 2021, an increase of DKK 3,339 million, or 111%. Net Financial Items Net financial items were comprised of the following: (DKK million) 2022 2021 Financial income: Interest and other financial income 324 197 Foreign exchange rate gain, net 1,034 1,470 Total financial income 1,358 1,667 Financial expenses: Interest and other financial expenses (21) (13) Loss on marketable securities, net (361) (246) Loss on other investments, net (298) (443) Total financial expenses (680) (702) Net financial items 678 965 Net financial items decreased by DKK 287 million, or 30%, which were primarily driven by: • Foreign exchange movements impacting Genmab's USD denominated marketable securities and cash and cash equivalents; in particular, the USD/DKK foreign exchange rate increased 8% from year-end 2020 to year-end 2021 as compared to only 6% from year-end 2021 to year-end 2022, • Loss on marketable securities driven by higher interest rates on Genmab's Danish mortgage investments in 2022 as compared to 2021, partly offset by, • Lower loss on other investments in 2022 as compared to 2021 driven primarily by the decrease in fair value of Genmab's investment in common shares of CureVac, and • Increase in interest income due to higher effective interest rates in the U.S., Europe and Denmark in 2022 as compared to 2021. Refer to Notes 4.2 and 4.5 for further details regarding foreign currency risk and net financial items, respectively. Financial Review |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag057.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;57 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** Corporate Tax Corporate tax expense for 2022 was DKK 1,513 million compared to DKK 975 million for 2021. The increase in corporate tax expense is primarily the result of Genmab's higher net profit before tax. The effective tax rate in 2022 was 21.5% compared to 24.5% in 2021. The decrease in Genmab's effective tax rate was mainly driven by the ability to offset current taxable income through the deduction of capitalized R&D costs in the Netherlands and utilization of U.S. net operating loss carryforwards. Refer to Note 2.4 for additional information regarding the corporate tax and deferred tax assets including management's significant judgements and estimates. Net Profit Net profit for 2022 was DKK 5,522 million compared to DKK 3,008 million in 2021. The increase of DKK 2,514 million, or 84%, was driven by the items described above. Liquidity and Capital Resources December 31, (DKK million) 2022 2021 Marketable securities 12,431 10,381 Cash and cash equivalents 9,893 8,957 Shareholders' equity 27,441 22,196 As of December 31, 2022 and December 31, 2021, cash and cash equivalents and marketable securities denominated in USD represented 86% of Genmab's total cash and cash equivalents and marketable securities. Marketable securities are invested in highly secure and liquid investments with short effective maturities. As of December 31, 2022, 75% of Genmab's marketable securities were long-term A rated or higher, or short-term rated A-1/P-1 by S&P, Moody's or Fitch compared to 68% as of December 31, 2021. As of December 31, 2022, DKK 9,893 million, as compared to DKK 8,957 million as of December 31, 2021, was held as cash and cash equivalents, and DKK 12,431 million, as compared to DKK 10,381 million as of December 31, 2021, was held as liquid investments in short-term government and other debt instruments. Cash and cash equivalents included short-term marketable securities of DKK 594 million at the end of December 2022, compared to DKK 296 million at the end of December 2021. In accordance with Genmab's accounting policy, securities purchased with a maturity of less than 90 days at the date of acquisition are classified as cash and cash equivalents. Genmab requires cash to meet our operating expenses and capital expenditures. We have funded our cash requirements since inception, including through December 31, 2022, primarily with royalty and milestone payments from our partners, upfront payments and equity financing. Genmab expects to continue to fund a significant portion of our development costs for proprietary product candidates as well as commercialization activities with cash received from royalties and milestone payments from partners. Genmab's expenditures on current and future pre-clinical and clinical development programs are subject to numerous uncertainties in timing and cost to completion. In order to advance our product candidates toward commercialization, the product candidates are tested in numerous pre-clinical safety, toxicology and efficacy studies. Genmab then conducts clinical trials for those product candidates that take several years or more to complete. The length of time varies substantially based upon the type, complexity, novelty and intended use of a product candidate. The cost of clinical trials may vary significantly over the life of a project as a result of a variety of factors, including: the number of patients required in the clinical trials; the length of time required to enroll trial participants; the number and location of sites included in the trials; the costs of producing supplies of the product candi-dates needed for clinical trials and regulatory submissions; the safety and efficacy profile of the product candidate; the use of CROs to assist with the management of the trials; and the costs and timing of, and the ability to secure, regulatory approvals. Genmab's expenses also fluctuate from period to period based on the degree of collaborative activities, timing of manufacturing campaigns, numbers of patients enrolled in clinical trials and the outcome of each clinical trial event. As a result, the Company is unable to determine with any degree of certainty the anticipated completion dates, duration and completion costs of research and development projects, or when and to what extent Genmab will receive cash inflows from the commercialization and sale of any product candidates. The Company also cannot predict the actual amount or timing of future royalties and milestone payments, and these may differ from estimates. Further, as the global COVID-19 pandemic has continued to evolve, there may be long-term impacts on the development, regulatory approval and commercialization of our product candidates and on net sales of our approved products by our collaboration partners. Genmab expects to make additional capital outlays and to increase operating expenditures over the next several years as the Company hires additional employees, supports pre-clinical devel-opment, manufacturing, clinical trial activities, product collaborations and commercialization activities. As spending increases on research, development and commercialization activities related to product collaborations, Genmab may be required to make certain capital outlays against which Genmab expects to receive reimbursement to the extent the outlay exceeds Genmab's share under the applicable collaboration agreement. The Company expects that the time-lag between the expenditure by us, on the one hand, and the reimbursement by a partner of its relevant share, on the other hand, will increase Genmab's working capital needs. To the extent the Company's capital resources are insufficient to meet future capital requirements, Genmab will need to finance Financial Review |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag058.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;58 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review operating requirements and cash needs through public or private equity offerings, debt financ-ings, or additional corporate collaboration and licensing arrangements. Refer to Notes 4.2 and 4.4 for additional information regarding our financial risks and marketable securities, respectively. Cash Flows The following table provides information regarding Genmab's cash flow for 2022 and 2021. Cash Flow (DKK million) 2022 2021 Cash provided by operating activities 3,912 2,228 Cash (used in) investing activities (2761) (961) Cash (used in)/provided by financing activities (789) (420) Increase in cash and cash equivalents 362 847 Exchange rate adjustments 574 850 Net cash provided by operating activities is primarily related to our operating profit, changes in operating assets and liabilities, reversal of net financial items, and adjustments related to non-cash transactions. Cash provided by operating activities increased compared to 2021 primarily driven by an increase in operating profit of DKK 3,339 million, partly offset by AbbVie milestones achieved during the fourth quarter of 2022 that were uncollected at year-end 2022 of DKK 1.1 billion, and an increase in corporate tax payments of DKK 841 million due to higher net profit before tax. Net cash (used in) investing activities primarily reflects differences between the proceeds received from the sale and maturity of our invest-ments and amounts invested, and the cash paid for investments in tangible assets. Purchases of marketable securities exceeded sales and maturities to a greater extent in 2022 compared to 2021. In 2021, investing activities also include the proceeds from the sale of CureVac shares of DKK 438 million. There were no sales of other investments in 2022. Net cash (used in) financing activities is primarily related to the purchase of treasury shares, exercise of warrants, lease payments, and payment of withholding taxes on behalf of employees on net settled Restricted Stock Units (RSUs). The increase in cash used in financing activities for the periods is primarily driven by cash payments for the purchase of treasury shares of DKK 908 million in 2022 compared to DKK 447 million in 2021. Exchange rate adjustments represent foreign currency gains or losses on Genmab's cash and cash equivalents, primarily driven by our cash and cash equivalents holdings denominated in USD. The USD/DKK foreign exchange rate increased 8% in 2021 as compared to only 6% in 2022. Balance Sheet As of December 31, 2022, total assets were DKK 30,278 million, compared to DKK 24,627 million as of December 31, 2021. As of December 31, 2022, assets are mainly comprised of marketable securities of DKK 12,431 million, cash and cash equivalents of DKK 9,893 million, and current receivables of DKK 5,910 million. The receivables consist primarily of amounts related to royalties, milestones, and reimbursement revenue from our collaboration agreements. The credit risk related to our receivables is not significant based on the high-quality nature of Genmab's collaboration partners. Refer to Note 3.5 for additional information regarding receivables. As of December 31, 2022, total liabilities were DKK 2,837 million compared to DKK 2,431 million as of December 31, 2021. The increase in total liabilities of DKK 406 million, or 17%, was driven by an increase in other payables of DKK 234 million primarily related to accrued compen-sation as a result of team growth from 2021 to 2022, and lease liabilities of DKK 172 million related to the commencement of leases in the Netherlands in 2022. Shareholders' equity as of December 31, 2022 was DKK 27,441 million compared to DKK 22,196 million as of December 31, 2021. The increase of DKK 5,245 million, or 24%, was driven primarily by Genmab's net profit and share-based compensation expense related to the issuance of shares under Genmab's warrant and RSU programs, partly offset by the purchase of treasury shares during the period. Genmab's equity ratio was 91% as of December 31, 2022 compared to 90% as of December 31, 2021. Financial Review |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag059.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;59 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** Financial Review Legal Matters—Janssen Binding Arbitrations In September 2020, Genmab commenced binding arbitration of two matters arising under its license agreement with Janssen relating to daratumumab. Under the license agreement, Genmab is, among other things, entitled to royalties from Janssen on net sales of daratumumab (marketed as DARZALEX for IV administration and as DARZALEX FASPRO in the U.S. and as DARZALEX SC in Europe for SC administration). In April 2022, the arbitral tribunal issued an award in the binding arbitration of the two matters. Genmab did not seek a review of the award, and the award is now final. The first matter concerned the question as to whether Janssen's obligation to pay royalties on sales of licensed product extends, in each appli-cable country, until the expiration or invalidation of the last-to-expire relevant Genmab-owned patent or the last-to-expire relevant Janssen-owned patent covering the product, as further defined and described in the license agreement. As to that matter, the tribunal determined by majority opinion that Janssen's obligation to pay royalties to Genmab on sales of licensed product, in each applicable country, extends through the expiration or invalidation of the last-to-expire relevant Genmab-owned patent covering the product or use thereof, but not the relevant Janssen-owned patent. The relevant Genmab-owned issued U.S., European and Japanese patents will expire in the late 2020s and early 2030s. The second matter concerned the question as to whether Genmab is required to share in Janssen's royalty payments to Halozyme for the Halozyme enzyme technology used in the SC formula-tion of daratumumab (marketed as DARZALEX FASPRO in the U.S.). The royalties Janssen pays to Halozyme represent a mid-single digit percentage rate of SC daratumumab sales. As to that matter, the tribunal ruled by majority opinion that Janssen is permitted to continue reducing its royalty payments to Genmab as an offset against a share of Janssen's royalty payments made to Halozyme. On June 9, 2022, Genmab announced the commencement of a second arbitration under the daratumumab license agreement with Janssen. This second arbitration follows from the award in the prior arbitration, where the tribunal ruled in favor of Janssen on the question as to whether Genmab is required to share in Janssen's royalty payments to Halozyme for its technology used in the daratumumab SC product. The tribunal based its ruling on the finding that DARZALEX FASPRO constitutes a new licensed product under the license agreement. In this second arbitration, Genmab is conse-quently seeking an award of USD 405 million plus interest in accrued milestone payments for DARZALEX FASPRO and a declaration that it is entitled to a new 13-year royalty term from the date of DARZALEX FASPRO's first commercial sale. See Company Announcement no. 21/2022. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag060.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;60 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Risk Management Genmab has core facilities in four countries and performs research and development activities with clinical trials conducted around the globe. We have also begun to commercialize medicines. Through our activities, we are exposed to a variety of risks, some of which are inherent in our business and/or beyond our control. These risks may have a significant impact on our business if not properly assessed and controlled. Maintaining a strong control environment, with adequate procedures for identification and assessment of risks and adhering to operational policies designed to reduce such risks to an acceptable level, is essential for the continued evolution of Genmab. It is our policy to identify and reduce the risks derived from our operations and to establish insurance coverage and other risk reduction and resilience mechanisms to mitigate any residual risk, wherever considered practicable. The Audit and Finance Committee of the Board of Directors performs a yearly review of Genmab's Enterprise Risk Program and relevant insurance coverage to ensure that they are appropriate. For further information about the risks and uncertainties that Genmab faces, refer to the current Form 20-F filed with the SEC. The use of Data, as defined in the Danish Financial Statements Act, both personal and non-personal, is essential to fulfilling Genmab's core purpose; and Genmab is committed to handling Data with integrity and in an ethical and compliant manner considering the impact our actions may have on individuals and society. During 2022, Genmab has developed a policy for Data Ethics in light of Section 99d of the Danish Financial Statements Act in which Genmab adopts the Data Ethics principles of the International Federation of Pharmaceutical Manufacturers & Associations (IFPMA). These principles complement and strengthen already existing Genmab policies and procedures, and they focus on the following areas: 1. Autonomy: Respect individuals' privacy, protect their rights, and honor confidentiality 2. Transparency: Individuals should be able to understand how their personal Data is used 3. Data Quality: The best quality Data available should be used to make decisions 4. Fairness and Non-discrimination: Data acquisition should be inclusive, equitable, and seek to support the industry's mission of responding to the needs of all patients 5. Ethics by Design: Controls to prevent harm and risks to individuals should be built into the design of Data architecture and Data processing 6. Responsible Data Sharing: Data sharing should be based on processes that actively and consistently consider, prioritize, and protect individual rights 7. Responsibility and Accountability: Data Ethics Principles should be operationalized through effective governance, clear standards, training, monitoring activities, and disciplinary sanctions The Genmab Data Ethics policy has been communicated to our management for further distribution and consideration within Genmab's various departments. During 2023, Genmab will focus on further embedding these principles into its operations, particularly in the areas of data privacy, DE&I, clinical trials, and the application of new technologies (e.g., Artificial Intelligence and Machine Learning), where policies, processes, and training materials will be aligned with the above-mentioned principles. Going forward, the Genmab Data Ethics policy and its principles will be anchored in the Genmab Code of Conduct as part of the overall Genmab Compliance program. The following is a summary of Genmab's key risk areas and how we address and mitigate such risks. Environmental and ethical risks are also covered in Genmab's statutory report on Corporate Responsibility. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag061.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;61 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** Risk related to Risk areas Mitigation Risk trend Business and Products The identification and development of successful products is expensive and includes time-consuming clinical trials with uncertain outcomes and the risk of failure to obtain regulatory approval in one or more jurisdictions. Genmab has a disciplined approach to investment, focusing on areas with the potential to maximize success, including new technologies and formats, scaling up to expand from early- to late-stage development and commercialization. Genmab has established various committees to ensure optimal selection of disease targets and formats of our antibody candidates, and to monitor progress of pre-clinical and clinical development. We strive to have a well-balanced product pipeline and continue to identify and search for new product candidates and closely follow the market. Genmab is dependent on the identification and development of new proprietary technologies and access to new third-party technologies. This exposes us to safety issues as well as other failures and setbacks related to use of such new or existing technologies. Genmab continually strives to identify and develop new technologies, such as the DuoBody, HexaBody, DuoHexaBody and HexElect technology platforms, and gain access to competitive and complementary new third-party technologies such as ADC technology and messenger ribonucleic acid (mRNA) technology. We closely monitor our pre-clinical programs and clinical trials to mitigate any unforeseen safety issues or other failures, or setbacks associated with the use of our proprietary technology platforms, ADC technology or mRNA technology. Genmab faces ongoing uncertainty about the successful commercialization of product candidates. This is a result of factors including immense competition on the basis of cost and efficacy as well as rapid technological change, which may result in others discovering, developing or commercializing competing products before and/or more successfully than us. From early in the research phase and throughout development, commercial potential and product commercialization, associated risks are assessed to ensure that final products have the potential to be commercially viable. Genmab attempts to control commercial risks in part by regularly monitoring and evaluating current market conditions, competing products and new technologies, to potentially gain access to new technologies and products that may supplement our pipeline. Genmab also strives to ensure market exclusivity for its own technologies and products by seeking patent protection. Genmab's near- and mid-term prospects are substantially dependent on continued clinical and commercial success of DARZALEX. DARZALEX is subject to intense competition in the multiple myeloma therapy market. Genmab focuses on its three-pronged strategy of focusing on our core competence, turning science into medicine and building a profitable and successful biotech to develop a broad pipeline of unique best-in-class or first-in-class antibody products with significant commercial potential. In addition, Genmab maintains a strong cash position, disciplined financial management, and a flexible and capital efficient business model to mitigate potential setbacks related to DARZALEX. In 2020, two additional Genmab-created antibody products, Kesimpta and TEPEZZA, were approved by the U.S. FDA. In 2021 and 2022, respectively, the first and second DuoBody-based medicines, RYBREVANT and TECVAYLI, were approved by the U.S. FDA and the European Commission. All of these provide Genmab with additional recurring royalty revenue. Tivdak, Genmab's first medicine, in development with Seagen, was approved by the U.S. FDA and product sales of Tivdak commenced in 2021. Genmab has exposure to product liability claims related to the use or misuse of our products and technologies. Product liability claims and/or litigation could materially affect our business and financial position, and Genmab therefore strives to maintain robust internal processes for the review, approval, and compliant use of promotion materials and also maintains appropriate product liability insurance for our clinical trials and our approved products and other coverage required under applicable laws. Our core research and manufacturing activities are carried out at a limited number of locations. Any event resulting in Genmab's or our vendors'/suppliers' inability to operate these facilities could materially disrupt our business. Genmab employs oversight and quality risk management principles. In addition, Genmab follows Good Laboratory Practices (GLP), Good Manufacturing Practices (GMP) and requires that our vendors operate with the same standards. Genmab has established a quality assurance (QA) department to set high-quality standards and monitor adherence to these Practices. Risk Management Risk Level in Relation to Last Year: Unchanged Decreased Increased |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag062.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;62 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Risk related to Risk areas Mitigation Risk trend Business and Products (continued) If we are unable to effectively manage Genmab's continued fast-paced growth or build our commercialization and other capabilities, our business, financial condition and net profits may be adversely affected. Any business disruption or failure to properly manage this continued growth and transformation in a manner that reflects and supports our organizational strategies and priorities, while assuring ethical business practices, prudent risk management, and commercial compliance, could have a material adverse effect on our business, financial condition, results of operations and cash flows. We have experienced rapid growth over the last several years, and we anticipate further growth as our pipeline advances, and we move toward further commercialization of products. Such growth, including enabling new commercialization, support and other functions, has placed significant demands on our management and infrastructure, including new operational and financial systems, as well as extending manufacturing and commercial outsource arrangements. Our success will depend in part upon our ability to manage this growth effectively through leadership, focused prioritization and talent management, and maintaining our robust, values-based, collaborative culture. As we continue to grow and evolve, we must continuously improve our operational, commercial, compliance, financial and management practices and controls. Genmab is subject to government regulations on pricing/ public reimbursement as well as other healthcare payer cost-containment initiatives; increased pressures by governmental and third-party payers to reduce healthcare costs. Genmab strives to develop differentiated, cost-effective products that are well-positioned to secure reasonable price reimbursement by government healthcare programs and private health insurers. Genmab has also established a US Government Affairs & Policy department to interact with federal and state policymakers to advance policies aimed at improving patient lives through access to quality healthcare. The US Market Access department was established to educate payers on the value of our products. Strategic Collaborations Genmab is dependent on existing and new partnerships with major pharmaceutical or biotech companies to support our business and develop and commercialize our products. Our business may suffer if our collaboration partners do not devote sufficient resources to our programs and products, do not successfully maintain, defend and enforce their intellectual property rights or do not otherwise have the ability to successfully develop or commercialize our products, independently or in collaboration with others. Our business may also suffer if we are not able to continue our current collaborations or establish new collaborations. Genmab strives to be an attractive and respected collaboration partner, and to pursue a close and open dialogue with our collaboration partners to share ideas and align on best practices and decisions within clinical development and commercialization to increase the likelihood that we reach our goals. Genmab is primarily dependent on one contract manufacturing organization to produce and supply our product candidates. Genmab is also dependent on clinical research organizations to conduct key aspects of our clinical trials, and on collaboration partners to conduct some of our clinical trials. Genmab oversees outsourcing and partnership relationships to ensure consistency with strategic objectives and service provider compliance with regulatory requirements, resources and performance. This includes assessment of contingency plans, availability of alternative service providers and costs and resources required to switch service providers. We continually evaluate financial solvency and require our suppliers to abide by a code of conduct consistent with Genmab's Code of Conduct. Risk Management Risk Level in Relation to Last Year: Unchanged Decreased Increased |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag063.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;63 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** Risk related to Risk areas Mitigation Risk trend Regulation, Legislation, and Compliance Genmab is subject to extensive legislative, regulatory and other requirements both during clinical development and commercialization and post-marketing approval, including healthcare, marketing/promotion, fraud and abuse, competition/ antitrust laws and regulations, as well as transparency, data protection and other requirements. Genmab is subject to strict disclosure obligations under applicable laws and regulations, including the EU Market Abuse Regulation. As a consequence of the listing on the Nasdaq Global Select market, we are subject to additional U.S. regulatory requirements, including U.S. securities laws and the U.S. Foreign Corrupt Practices Act, and may become more exposed to U.S. class actions. To ensure compliance with applicable healthcare laws and regulations, Genmab has established a robust compliance program, including a Code of Conduct that is evaluated periodically and sets high ethical standards on which all colleagues receive regular training. Also, our head of Global Compliance reports directly to the CEO. The data protection area, including policies and guidance for the processing and protection of personal data, is supported by the Company's Data Protection Officer. To further support compliance with regulatory, legal and other requirements applicable to our business and operations, including current Good Laboratory Practices (cGLP), current Good Clinical Practices (cGCP) and current Good Manufacturing Practices (cGMP), Genmab has established a quality assurance department whose function includes staying abreast of and adhering to regulatory and legislative changes relevant to quality standards. Genmab has also established relevant procedures and guidelines to ensure transparency with respect to providing timely, adequate and correct information to the market and otherwise comply with applicable securities laws and other legal and regulatory requirements. Genmab has an Internal Audit function that reports to the Audit and Finance Committee of the Board of Directors and administratively reports to the CFO. Legislation, regulations, industry codes and practices, and their application may change from time to time. To prevent unwarranted consequences of new and amended legislation, regulations, etc., Genmab strives to stay current with respect to all applicable legislation, regulations, industry codes and practices by means of its internal compliance function and related governance bodies as well as internal and external legal counsel. Also, internal procedures for review and refinement of contracts are ongoing to ensure contractual consistency and compliance with applicable legislation, regulation, and other standards. Intellectual Property Genmab is dependent on protecting our own intellectual property rights to regain our investments and protect our competitive positions. We may become involved in lawsuits to protect or enforce our patents or other intellectual property which could result in costly litigation and unfavorable outcomes. Claims may be asserted against us that we infringe the intellectual property of third parties, which could result in costly litigation and unfavorable outcomes. Genmab files and prosecutes patent applications to optimally protect its products and technologies. To protect trade secrets and technologies, Genmab maintains strict confidentiality standards and agreements for employees and collaborating parties. Genmab actively monitors third-party patent positions within our relevant fields to avoid violating any third-party patent rights. Finances Genmab may need additional funding. Because Genmab's future commercial potential and operating profits are hard to predict, Genmab's policy is to maintain a strong capital base so as to maintain investor, creditor and market confidence, and a continuous advancement of Genmab's product pipeline and business in general. Genmab is exposed to different kinds of financial risks, including currency exposure and changes in interest rates as well as changes in Danish, U.S. or foreign tax laws or related compliance requirements. Genmab has established financial risk management guidelines to identify and analyze relevant risks, to set appropriate risk limits and controls, and to monitor the risks and adherence to limits. Please refer to Note 4.2 of the financial statements for additional information regarding financial risks. Risk Management Risk Level in Relation to Last Year: Unchanged Decreased Increased |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag064.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;64 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Risk related to Risk areas Mitigation Risk trend Management and Workforce Genmab may have an inability to attract and retain suitably qualified team members as it continues to grow. To attract and retain our highly skilled team, including the members of Genmab's Senior Leadership, Genmab offers competitive remuneration packages, including share-based remuneration. Genmab strives to create a positive and energizing working environment with development and training opportunities for its team members. Genmab has strong core values that nourish high-integrity and ethical behavior, respectful and candid tone and culture, as well as trust and teamwork. Please refer to Note 4.6 of the financial statements for additional information regarding share-based compensation. Cybersecurity Genmab may be subject to malicious cyber-attacks which can lead to the theft or leakage of intellectual property, sensitive business data, or personal employee or patient data, with the result of significant business disruptions, monetary loss or fines from authorities, or reputational damage. Genmab has implemented robust security controls and processes to enhance the identification of potential data/ systems security issues and mitigate the risk of security breaches. Genmab makes use of the National Institute of Standards and Technology (NIST) Cybersecurity Framework and other security standards to define and implement such security controls. Due to the continually changing threat environment, regular assessments are executed to ensure that implemented security controls and processes follow the threat profile of the Company and effectively support Genmab's ambitious business strategy. The risk of security breaches is regarded as enterprise risk and the Company's threat profile, the security program and security incidents are presented and discussed in meetings of the Global Compliance and Risk Committee and the Audit and Finance Committee of the Board of Directors. COVID-19 Pandemic The global outbreak of COVID-19 has continued to evolve, may be further prolonged, and may have long-term impacts on the development, regulatory approval and commercialization of our product candidates and on net sales of our approved products. The extent, length and consequences of the pandemic are uncertain and impossible to predict. The factors discussed above, as well as other factors which are currently unanticipated or unforeseeable, may result in further and other unforeseen material adverse impacts on our business and financial performance. Genmab has a COVID-19 response team, led by the CEO, that monitors the situation and implements precautionary measures based on local recommendations, as necessary to help limit the impact of COVID-19 at our workplace and on our communities, and that helps ensure business continuity and mitigate effects on employee well-being. While global health authorities and global vaccination efforts alleviated some of the adverse impacts of the COVID-19 pandemic, Genmab assesses the situation on an ongoing basis in close contact with clinical trial sites, physicians and CROs to evaluate the impact and challenges posed by the COVID-19 situation and manage them accordingly. Climate Genmab's inability to manage the carbon footprint from our business operations; climate-related events may impact our business operations or that of our third-party partners or suppliers. In 2022, we continued the assessment of our carbon footprint and the implementation of the TCFD recommendations. We calculated our Scope 1 and 2 emissions for 2022 in accordance with the global standard for carbon accounting, the GHG Protocol. In 2022 we also initiated the process of estimating our Scope 3 footprint in accordance with the GHG Protocol. Genmab makes use of scenario analysis to evaluate our risks and opportunities due to the rapid pace of world climate change. Genmab's work with climate strategy, carbon reduction targets, climate-related financial risk, relevant prevention and mitigation measures will be presented to the Board of Directors biannually. Risk Management Risk Level in Relation to Last Year: Unchanged Decreased Increased |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag065.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;65 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** As an international biotech company dedicated to improving the lives of cancer patients around the world, Genmab operates within a heavily regulated environment that exposes us to an ever-evolving set of risks, some of which are beyond our control. We maintain facilities in four countries, conduct activities in additional areas, and perform an array of essential innovation, research, development, commercialization and support functions, all of which pose risks to our operations and success. Specifically, these operations and activities expose us to risks that include but may not be limited to financial, research and development, regulatory, IT/data/technology, staffing, compliance, legal, and also environmental risks. In order to assure that we are positioned to effectively identify and mitigate the potential impacts of these risks, Genmab has dedicated significant resources toward enabling a more robust ERM framework under the Global Compliance & Risk function that reports directly to the CEO. In concert with a refreshed Code of Conduct, company policies and procedures, Genmab has chartered a Global Compliance and Risk Governance Committee (GCRC) co-chaired by the CEO and the head of Compliance & Risk. Genmab has also updated our risk model and framework to include significantly enhanced risk oversight, mitigation, governance and reporting, all of which we believe positions us to better manage the risks associated with our business, now and into the future. Enterprise Risk Management Effective ERM starts with strong governance Board of Directors and Audit and Finance Committee Board of Directors delegates ERM/Risk oversight to the Audit and Finance Committee but retains visibility of ERM progress. The Audit and Finance Committee is accountable to ensure management appropriately manages the risks to the business. Executive Management Maintains ultimate ownership of and accountability for management of top risks, enabling proper linkage of risk management to strategic initiatives and business decisions. GCRC Validation of risk identification, prioritization, strategic and tactical ownership of risk mitigation plans and reporting. ERM Framework Routinely gathers risks, evaluates with risk sponsors, prioritizes and reports to the GCRC, Executive Management and Board of Directors, driving deep risk discussions, and supporting risk sponsors and management in facilitating robust enterprise risk management processes, risk-intelligent decision-making and key risk capabilities. Risk Sponsors and Business Champions Manage risks in normal course of business, executing risk plans/miti-gation activities, and monitoring and reporting key risk information. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag066.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;66 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Corporate Governance Genmab works diligently to improve its guidelines and policies for corporate governance, taking into account the recent trends in international and domestic requirements and recommendations. Genmab's commitment to corporate governance is based on ethics and integrity and forms the basis of its effort to strengthen the confidence that existing and future shareholders, partners, employees and other stakeholders have in Genmab. The role of shareholders and their interaction with Genmab is important. Genmab believes that open and transparent communication is necessary to maintain the confidence of Genmab's shareholders and achieves this through company announcements, investor meetings and company presentations. Genmab is committed to providing reliable and transparent information about its business, financial results, development programs and scientific results in a clear and timely manner. All Danish companies listed on the Nasdaq Copenhagen are required to disclose in their annual reports how they address the Recommen-dations for Corporate Governance issued by the Committee on Corporate Governance in December 2020 (the "Recommendations"), applying the "comply-or-explain" principle. Genmab follows the Recommendations, except for one specific sub-area where Genmab's corporate governance principles differ from the Recommendations: • The Recommendations provide that according to a company's takeover contingency procedures, the board of directors abstains from countering any takeover bids by taking actions that seek to prevent the shareholders from deciding on the takeover bid, without the approval of the general meeting. Genmab does not have such a restriction in its takeover contingency procedures and retains the right in certain circumstances to reject takeover bids without consulting the shareholders. Genmab believes this provides the Board of Directors with the needed flexibility to best respond to takeover bids and to negotiate with bidders; retaining this flexibility helps the Board of Directors meet its objectives in protecting and creating value in the interest of the shareholders. Actions will be determined on a case-by-case basis with due consideration to the interests of the shareholders and other stakeholders. Genmab publishes its statutory report on Corporate Governance for the financial year 2022 cf. Article 107b of the Danish Financial Statements Act ("Lovpligtig redegørelse for virksomhed-sledelse jf. årsregnskabslovens § 107 b") on the Company's website, including a detailed descrip-tion of the Board of Directors' consideration in respect of all the Recommendations. The statutory report on Corporate Governance can be found on Genmab's website https://ir.genmab.com/ corporate-governance#content. The Board of Directors The Board of Directors plays an active role within Genmab in setting the strategies and goals for Genmab and monitoring its operations and results. Board duties include establishing policies for strategy, accounting, organization and finance and the appointment of Executive Management members. The Board of Directors also assesses Genmab's capital and share structure and is responsible for approving share issues and the grant of warrants and RSUs. The Board of Directors has established an annual process whereby the Board of Directors' performance is assessed through self-evaluation to verify that the Board of Directors is capable of fulfilling its function and responsibilities. When performing these evaluations external assistance is obtained every year. The outcome of the Board of Directors' 2022 self-assessment was positive with only minor areas for improve-ment identified. Board Committees To support the Board of Directors in its duties, the Board of Directors has established and appointed a Compensation Committee, an Audit and Finance Committee, a Nominating and Corporate Governance Committee and a Scientific Committee. These committees are charged with reviewing issues pertaining to their respective fields that are due to be considered at Board of Directors' meetings. Written charters specifying the tasks and responsibilities for each of the committees are available on Genmab's website www.genmab.com. For more details on the work, composition and evaluation of the Board of Directors and its committees, reference is made to the statutory report on Corporate Governance. Remuneration Policy A Remuneration Policy applying to the compen-sation of members of the Board of Directors and the registered Executive Management of Genmab A/S has been prepared in accordance with Sections 139 and 139a of the Danish Companies Act and was most recently considered and adopted by the 2021 Annual General Meeting pursuant to the Danish Companies Act (in Danish "Selskabsloven"). The Remuneration Policy contains an exhaustive description of the remuneration components for members of the Board of Directors and the registered Executive Management and includes  |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag067.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;67 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** Corporate Governance the reasons for choosing the individual compo-nents of the remuneration and a description of the criteria on which the balance between the individual components of the remuneration is based. The latest version, which was adopted by the General Meeting in 2021, can be downloaded from Genmab's website https://ir.genmab.com/ governance/compensation#content. Compensation Report In accordance with the Recommendations, Genmab has prepared a compensation report for the financial year 2022 that includes infor-mation on the total remuneration received by each member of the Board of Directors and the registered Executive Management from Genmab A/S and other Group companies for the last three years, including information on the most important content of retention and resignation arrangements and the correlation between the remuneration and company strategy and relevant related goals (the "Compensation Report"). The Compensation Report can be found on Genmab's website https://ir.genmab.com/governance/ compensation#content. Change of Control The Danish Financial Statements Act (Section 107a) contains rules relating to listed companies with respect to certain disclosures that may be of interest to the stock market and potential takeover bidders, in particular in relation to disclosure of change of control provisions. In the event of a change of control, change of control clauses are included in some of our collaboration, develop-ment and license agreements as well as in service agreements for certain employees. Collaboration, Development and License Agreements Genmab has entered into collaboration, devel-opment and license agreements with external parties, which may be subject to renegotia-tion in the case of a change of control event as specified in the individual agreements. However, any changes in the agreements are not expected to have significant influence on our financial position. Service Agreements with Executive Management and Employees The service agreements with each registered member of the Executive Management may be terminated by Genmab with no less than 12 months' notice and by the registered member of the Executive Management with no less than six months' notice. In the event of a change of control of Genmab, the termination notice due to the registered member of the Executive Management is extended to 24 months. In the event of termi-nation by Genmab (unless for cause) or by a registered member of Executive Management as a result of a change of control of Genmab, Genmab is obliged to pay a registered member of Executive Management a compensation equal to his/her existing total salary (including benefits) for up to two years in addition to the notice period. In addition, Genmab has entered into service agreements with a limited number of employees according to which Genmab may become obliged to compensate the employees in connection with a change of control of Genmab. If Genmab, as a result of a change of control, terminates the service agreement without cause or changes the working conditions to the detriment of the employee, the employee shall be entitled to terminate the employment relationship without further cause with one month's notice in which case Genmab shall pay the employee a compensation equal to one-half, one or two times the employee's existing annual salary (including benefits). Change of control clauses related to our warrant and RSU programs are outlined in Note 4.6. Share capital Information on share capital is included in Note 4.7. Unless otherwise provided in the Danish Companies Act, the adoption of any resolution to amend Genmab A/S' articles of association shall be subject to the affirmative vote of not less than two thirds of the votes cast, as well as of the voting share capital represented at the general meeting. Genmab A/S' entire articles of association can be found on our website www.genmab.com. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag068.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;68 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Board of Directors Pernille Erenbjerg Danish, 55, Female Deputy Chair (Independent, elected by the General Meeting); Chair of the Audit and Finance Committee, Member of the Nominating and Corporate Governance Committee First elected 2015, current term expires 2023 Special Competencies Senior executive management and broad business experience from the telecoms, media and tech industries. Extensive experience with operation and strategic transformation of large and complex compa-nies, including digital transformations and digitally based innovation. ESG experience from executive and non-executive positions. Comprehensive all-around background within finance, including extensive exposure to public and private equity and debt investors. Certified Public Accountant background (no longer practicing). Responsible for major transformation processes in complex organi-zations including M&A. Former CEO and President of TDC Group A/S. Due to her experience and background within accounting, Pernille Erenbjerg qualifies as an audit committee financial expert. Current Board Positions • Chair: Nordic Entertainment Group (NENT) • Deputy Chair: Millicom1 • Member: RTL Group2, GlobalConnect 1. Chair of Compensation Committee 2. Chair of Audit Committee Deirdre P. Connelly Hispanic/American, 62, Female Board Chair (Independent, elected by the General Meeting); Chair of the Nominating and Corporate Governance Committee, Member of the Compensation Committee and the Audit and Finance Committee First elected 2017, current term expires 2023 Special Competencies More than 30 years' experience as a corporate leader and exten-sive experience in corporate governance as a board member. Comprehensive experience with business turnaround, corporate culture transformation, product launch and talent development. Successfully directed the launch of more than 20 new pharmaceu-tical drugs. Former President, North America Pharmaceuticals for GlaxoSmithKline. Current Board Positions • Member: Lincoln Financial Corporation1 , Macy's Inc.2 1. Chair of Corporate Governance Committee, Member of Audit Committee 2. Chair of Nominating and Governance Committee, Member of Compensation and Management Development Committee Anders Gersel Pedersen, M.D., Ph.D. Danish, 71, Male Board Member (Non-independent, elected by the General Meeting); Chair of the Compensation Committee, Member of the Nominating and Corporate Governance Committee and the Scientific Committee First elected 2003, current term expires 2023 Special Competencies Business and management experience in the pharmaceutical industry, including expertise in clinical research, development, regu-latory affairs and product life cycle management. Former Executive Vice President of Research & Development of H. Lundbeck A/S. Current Board Positions • Chair: Aelis Farma S.A.S. • Deputy Chair: Bavarian Nordic A/S1 • Member: Hansa Biopharma AB2, Bond 2 Development 2 GP Limited 1. Member of Nomination and Compensation Committee, Member of Science, Technology & Investment Committee 2. Chair of Scientific Committee, Member of Remuneration Committee |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag069.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;69 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** Elizabeth A. O'Farrell American, 58, Female Board Member (Independent, elected by the General Meeting); Member of the Compensation Committee and the Audit & Finance Committee First elected 2022, current term expires 2023 Special Competencies Solid financial experience including strategic, operational and reporting across the value chain. Additional expertise in leading cross-functional teams, championing culture, and driving paradigm changing contributions within finance and the enterprise through collaboration and influence. Over 24 years' experience at Eli Lilly, in addition to experience at Price Waterhouse and Whipple & Company Corporation. Current Board Positions • Chair: PDL BioPharma • Member: LENSAR1 , Geron Corporation2, Karius3 1. Chair of Audit Committee 2. Chair of Audit Committee 3. Chair of Audit Committee Rolf Hoffmann German, 63, Male Board Member (Independent, elected by the General Meeting); Member of the Audit and Finance Committee and the Scientific Committee First elected 2017, current term expires 2023 Special Competencies Extensive international management experience with expertise in creating and optimizing commercial opportunities in global markets. Additional expertise in P&L management, governance and Corporate Integrity Agreement Management, compliance and organizational efficiency. Over 20 years' experience in the international pharmaceu-tical and biotechnology industries at Eli Lilly and Amgen. Current Position, Including Managerial Positions • Adjunct Professor Strategy and Entrepreneurship, University of North Carolina Business School Current Board Positions • Member: Paratek Pharmaceuticals, Inc.1 , IDT Biologika, Semdor Pharma 1. Member of Nominating and Corporate Governance Committee Board of Directors Paolo Paoletti, M.D. Italian (U.S. Citizen), 72, Male Board Member (Independent, elected by the General Meeting); Chair of the Scientific Committee, Member of the Compensation Committee First elected 2015, current term expires 2023 Special Competencies Extensive experience in research, development and commercial-ization in the pharmaceutical industry. Successfully conducted submissions and approvals of new cancer drugs and new indications in the U.S. and in Europe. Responsible for seven new medicines for cancer patients during his 10 years at GlaxoSmithKline and one new cancer medicine during his time at Eli Lilly. Current Position, Including Managerial Positions • Member of the Investment Committee for Apollo Therapeutics Limited • Scientific Advisor for 3B Future Health Fund Current Board Positions • Member: Akamis Bio Limited |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag070.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;70 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Mijke Zachariasse, Ph.D. Dutch, 49, Female Board Member (Non-independent, elected by the employees) First elected 2019, current term expires 2025 Special Competencies Broad experience in people and business management in the natural sciences sector. Specific expertise in building strategic partnerships across sectors, financial and fund management, and setting research strategies in the academic sector. Current Position, Including Managerial Positions • Senior Director, Head of Antibody Research Materials at Genmab Board of Directors Martin Schultz Danish, 47, Male Board Member (Non-independent, elected by the employees) First elected 2022, current term expires 2025 Special Competencies Broad experience within clinical trial management with a substantial understanding and knowledge of research and development. Specific expertise in project management, vendor collaboration, contract and budget management. Current Position, Including Managerial Positions • Senior Director, Clinical Operations at Genmab Takahiro Hamatani Japanese, 48, Male Board Member (Non-independent, elected by the employees) First elected 2022, current term expires 2025 Special Competencies Over 20 years' experience in the pharmaceutical industry in various roles including finance, sales/marketing, and corporate strategy. Extensive expertise in strategic business planning and finance business partnering. Experience in successful product launches, geographical expansions, and business development deals. Certified Public Accountant in the U.S. Current Position, Including Managerial Positions • Senior Director, Finance Japan at Genmab |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag071.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;71 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** Senior Leadership Anthony Pagano American, 45, Male Executive Vice President & Chief Financial Officer Special Competencies Significant knowledge and experience in the life sciences industry particularly as it relates to corporate finance, corporate development, stra-tegic planning, general management, treasury, accounting and corporate governance. Jan G. J. van de Winkel, Ph.D. Dutch, 61, Male President & Chief Executive Officer Special Competencies Extensive antibody creation and development expertise, broad knowledge of the biotechnology industry and executive management skills. Current Board Positions • Chair: Hookipa Pharma • Member: Leo Pharma Anthony Mancini Canadian-Italian (U.S. Citizen), 52, Male Executive Vice President & Chief Operating Officer Special Competencies Significant expertise and experience in the life sciences industry across strategic and operational leadership roles; commercialization & launch, strategic planning, partnerships/alliances, general management, leading large Biopharma P&Ls and organizations. Judith Klimovsky, M.D. Argentinian (U.S. Citizen), 66, Female Executive Vice President & Chief Development Officer Special Competencies Extensive expertise in oncology drug devel-opment from early clinical stages through to marketing approval, experience in clinical practice and leading large teams in pharmaceutical organizations. Current Board Positions • Member: Bellicum Pharmaceuticals |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag072.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;72 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Birgitte Stephensen Danish, 62, Female Executive Vice President, Chief Legal Officer Special Competencies Intellectual property and legal expertise in the biotechnology field. Tahamtan Ahmadi, M.D., Ph.D. Iranian-German (U.S. Citizen), 50, Male Executive Vice President & Chief Medical Officer, Head of Experimental Medicines Special Competencies Significant expertise in global regulatory and clinical drug development across entire spectrum from pre-IND to life cycle management; drug discovery and translational research. Martine J. van Vugt, Ph.D. Dutch, 52, Female Senior Vice President, Corporate Strategy and Planning Special Competencies Extensive knowledge of and experience in Corporate Strategy, Business Development, as well as Portfolio, Project and Alliance Management. Christopher Cozic American, 45, Male Executive Vice President, Chief People Officer Special Competencies Expertise in strategic leadership, organization design, human resource management, policy development, employee relations, organizational development, and a heavy concentration in all aspects of corporate growth and expansion. Senior Leadership |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag073.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;73 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review Management's Review **Table of Contents** Shareholders and Share Information Ownership Genmab is dual listed on the Nasdaq Copenhagen and the Nasdaq Global Select Market in the U.S. under the symbol GMAB. Our communication with the capital markets complies with the disclosure rules and regulations of these exchanges. As of December 31, 2022, the number of registered shareholders totaled 78,928 shareholders holding a total of 64,166,414 shares, which represented 97% of the total share capital of 65,961,573. The following shareholders are registered in Genmab's register of shareholders as being the owner of a minimum of 5% of the voting rights or a minimum of 5% of the share capital (one share equals one vote) as of December 31, 2022: • BlackRock, Inc., 55 East 52nd Street, New York, New York 10055, United States of America (6.8%) • Wellington Management Group LLP, 280 Congress Street, Boston, Massachusetts, United States of America (6.18%) Shareholders registered in the Company's shareholder registry may sign up for electronic shareholder communications via Genmab's investor portal. The investor portal can be accessed at Genmab's website www.genmab. com/investors/. Electronic shareholder commu-nication enables Genmab to, among other things, quickly and efficiently call general meetings. The following table shows share data as of December 31, 2022. Share Data Denmark U.S. Number of shares at December 31, 2022 65,961,573 4,661,201 (represented by 46,612,010 American Depository Shares (ADSs)) Listing Nasdaq Copenhagen Nasdaq Global Select Market, New York Ticker Symbol GMAB GMAB Index Membership OMX Nordic Large Cap Index OMX Copenhagen Benchmark Index OMX Copenhagen 25 Index (OMXC25) Nasdaq Biotech Index The charts included here illustrate the performance of the Genmab share during 2022 and the geographical distribution of our shareholders. As of December 31, 2022 Genmab's shares closed at DKK 2,941 and ADSs closed at USD 42.38. Please refer to Note 4.7 of the financial statements for additional information regarding Genmab's share capital including authorizations to issue shares and purchase its own shares. Stock Performance Comparison YTD 2022 (Index 100 = stock price on December 31, 2021) Geographical Shareholder Distribution\* \* Based on Nasdaq Corporate Solutions aggregated data per June 30, 2021 and June 30, 2022 \*\* "Other" includes shares held in other countries and shares not held in nominee accounts, including OTC traded shares 70 80 90 100 110 120 130 Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec Genmab OMXC25 Index Nasdaq Biotech Index 30% 22% 3% 4% 2021 2022 4% 3% 8% 10% 20% 19% 35% 42% USA Denmark UK Netherlands Luxembourg Other\*\* |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag074.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;74 Financial Statements Other Information Genmab \| 2022 Annual Report \| Management's Review **Table of Contents** Management's Review Shareholders and Share Information Genmab is a Foreign Private Issuer as defined in the SEC's rules and regulations. The determination of foreign private issuer status is made annually on June 30. We will next make a determination with respect to our foreign private issuer status on June 30, 2023. American Depositary Receipt (ADR) Program Genmab has a sponsored Level 3 ADR program with Deutsche Bank Trust Company Americas. An ADS is a share certificate representing ownership of shares in a non-U.S. corporation. ADSs issued under Genmab's ADR Program are quoted and traded in U.S. dollars on the Nasdaq Global Select Market in the United States. Ten Genmab ADSs correspond to one Genmab ordinary share. Genmab's ADR ticker symbol is GMAB. For more information on Genmab's ADR Program, visit https://ir.genmab.com/ adr-program#content. Investor Relations Genmab's Investor Relations department aims to ensure relevant, accurate and timely information is available to our investors and the financial community. We maintain an ongoing dialogue with sell-side equity analysts, as well as major institutional and retail shareholders. A list of the current analysts covering Genmab can be found at our website along with financial reports, company announcements, current presentations, fact sheets and other downloads. Contact: For Media Relations: Marisol Peron Senior Vice President, Global Communications & Corporate Affairs T: +1 609 524 0065; E: mmp@genmab.com For Investor Relations: Andrew Carlsen Vice President, Head of Investor Relations T: +45 33 77 95 58; E: acn@genmab.com Annual General Meeting Genmab's Annual General Meeting will be held on March 29, 2023 at 2:00 PM CEST. Further details will be included in the notice to convene the Annual General Meeting. Financial Calendar for 2023 Annual General Meeting 2023 Wednesday, March 29, 2023 Publication of the Interim Report for the first quarter 2023 Wednesday, May 10, 2023 Publication of the Interim Report for the first half 2023 Thursday, August 3, 2023 Publication of the Interim Report for the first nine months 2023 Tuesday, November 7, 2023 |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag075.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;75 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements Financial Statements In this section 76 Financial Statements for the Genmab Group 116 Financial Statements of the Parent Company 132 Directors' and Management's Statement on the Annual Report 133 Independent Auditor's Reports |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag076.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;76 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group **Table of Contents** Primary Statements 77 Consolidated Statements of Comprehensive Income 78 Consolidated Balance Sheets 79 Consolidated Statements of Cash Flows 80 Consolidated Statements of Changes in Equity Section 1 Basis of Presentation 81 1.1 Nature of the Business and Accounting Policies 84 1.2 New Accounting Policies and Disclosures 84 1.3 Management's Judgements and Estimates under IFRS Section 2 Results for the Year 85 2.1 Revenue 87 2.2 Information about Geographical Areas 87 2.3 Staff Costs 88 2.4 Corporate and Deferred Tax 89 2.5 Profit Per Share Section 3 Operating Assets and Liabilities 90 3.1 Intangible Assets 91 3.2 Property and Equipment 92 3.3 Leases 93 3.4 Other Investments 93 3.5 Receivables 94 3.6 Deferred Revenue 94 3.7 Other Payables Section 4 Capital Structure, Financial Risk and Related Items 95 4.1 Capital Management 95 4.2 Financial Risk 97 4.3 Financial Assets and Liabilities 99 4.4 Marketable Securities 100 4.5 Financial Income and Expenses 101 4.6 Share-Based Instruments 107 4.7 Share Capital Section 5 Other Disclosures 109 5.1 Remuneration of the Board of Directors and Executive Management 112 5.2 Related Party Disclosures 112 5.3 Commitments 112 5.4 Fees to Auditors Appointed at the Annual General Meeting 112 5.5 Adjustments to Cash Flow Statements 113 5.6 Collaborations and Technology Licenses 115 5.7 Subsequent Events The financial statements in the 2022 Annual Report are grouped into the following sections: Primary Statements; Basis of Presentation; Results for the Year; Operating Assets and Liabilities; Capital Structure, Financial Risk and Related Items; and Other Disclosures. Each note to the financial statements includes information about the accounting policies applied and significant manage-ment judgements and estimates in addition to the financial numbers. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag077.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;77 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Primary Statements Income Statement (DKK million) Note 2022 2021 2020 Revenue 2.1, 2.2 14,595 8,482 10,111 Research and development expenses 2.3, 3.1, 3.2 (5562) (4181) (3137) Selling, general and administrative expenses 2.3, 3.2 (2676) (1283) (661) Operating expenses (8238) (5464) (3798) Operating profit 6,357 3,018 6,313 Financial income 4.5 1,358 1,667 1,149 Financial expenses 4.5 (680) (702) (1558) Net profit before tax 7,035 3,983 5,904 Corporate tax 2.4 (1513) (975) (1146) Net profit 5,522 3,008 4,758 Basic net profit per share 2.5 84.45 46.00 73.00 Diluted net profit per share 2.5 83.65 45.54 72.21 Statement of Comprehensive Income Net profit 5,522 3,008 4,758 Other comprehensive income: Amounts which may be re-classified to the income statement: Exchange differences on translation of foreign operations 17 27 (44) Total comprehensive income 5,539 3,035 4,714 Consolidated Statements of Comprehensive Income |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag078.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;78 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Consolidated Balance Sheets (DKK million) Note December 31, 2022 December 31, 2021 Assets Intangible assets 2.2, 3.1 146 254 Property and equipment 2.2, 3.2 799 621 Right-of-use assets 2.2, 3.3 523 354 Receivables 2.2, 3.5 48 27 Deferred tax assets 2.4 252 264 Other investments 3.4 133 371 Total non-current assets 1,901 1,891 Corporate tax receivable 2.4 143 31 Receivables 3.5 5,910 3,367 Marketable securities 4.2, 4.4 12,431 10,381 Cash and cash equivalents 9,893 8,957 Total current assets 28,377 22,736 Total assets 30,278 24,627 Shareholders' Equity and Liabilities Share capital 4.7 66 66 Share premium 4.7 12,309 12,029 Other reserves 98 81 Retained earnings 14,968 10,020 Total shareholders' equity 27,441 22,196 Lease liabilities 3.3 523 363 Deferred revenue 3.6 480 487 Other payables 3.7 11 13 Total non-current liabilities 1,014 863 Lease liabilities 3.3 74 62 Deferred revenue 3.6 33 26 Other payables 3.7 1,716 1,480 Total current liabilities 1,823 1,568 Total liabilities 2,837 2,431 Total shareholders' equity and liabilities 30,278 24,627 Primary Statements |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag079.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;79 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group (DKK million) Note 2022 2021 2020 Cash flows from operating activities: Net profit before tax 7,035 3,983 5,904 Reversal of financial items, net 4.5 (678) (965) 409 Adjustment for non-cash transactions 5.5 801 526 459 Change in operating assets and liabilities 5.5 (1930) (770) 987 Cash flows from operating activities before financial items 5,228 2,774 7,759 Interest received 283 208 170 Interest elements of lease payments 3.3 (15) (12) (9) Interest paid (1) – (11) Corporate taxes paid (1583) (742) (1476) Net cash provided by operating activities 3,912 2,228 6,433 Cash flows from investing activities: Investment in tangible assets 3.2 (317) (252) (307) Marketable securities bought (9659) (15514) (12414) Marketable securities sold 7,254 14,469 10,370 Other investments bought 3.4 (39) (102) – Other investments sold 3.4 – 438 – Net cash (used in) investing activities (2761) (961) (2351) Cash flows from financing activities: Warrants exercised 280 135 140 Principal elements of lease payments 3.3 (73) (58) (44) Purchase of treasury shares (908) (447) – Payment of withholding taxes on behalf of employees on net settled RSUs (88) (50) (25) Net cash provided by (used in) financing activities (789) (420) 71 Changes in cash and cash equivalents 362 847 4,153 Cash and cash equivalents at the beginning of the period 8,957 7,260 3,552 Exchange rate adjustments 574 850 (445) Cash and cash equivalents at the end of the period 9,893 8,957 7,260 Cash and cash equivalents include: Bank deposits 9,299 8,661 5,054 Short-term marketable securities 594 296 2,206 Cash and cash equivalents at the end of the period 9,893 8,957 7,260 Primary Statements Consolidated Statements of Cash Flows |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag080.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;80 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group (DKK million) Share capital Share premium Translation reserves Retained earnings Shareholders' equity Balance at December 31, 2019 65 11,755 98 2,130 14,048 Net profit – – – 4,758 4,758 Other comprehensive income – – (44) – (44) Total comprehensive income – – (44) 4,758 4,714 Transactions with owners: Exercise of warrants 1 139 – – 140 Share-based compensation expenses – – – 200 200 Net settlement of RSUs – – – (25) (25) Tax on items recognized directly in equity – – – 44 44 Balance at December 31, 2020 66 11,894 54 7,107 19,121 Net profit – – – 3,008 3,008 Other comprehensive income – – 27 – 27 Total comprehensive income – – 27 3,008 3,035 Transactions with owners: Exercise of warrants – 135 – – 135 Purchase of treasury shares – – – (447) (447) Share-based compensation expenses – – – 310 310 Net settlement of RSUs – – – (50) (50) Tax on items recognized directly in equity – – – 92 92 Balance at December 31, 2021 66 12,029 81 10,020 22,196 Net profit – – – 5,522 5,522 Other comprehensive income – – 17 – 17 Total comprehensive income – – 17 5,522 5,539 Transactions with owners: Exercise of warrants – 280 – – 280 Purchase of treasury shares – – – (908) (908) Share-based compensation expenses – – – 439 439 Net settlement of RSUs – – – (88) (88) Tax on items recognized directly in equity – – – (17) (17) Balance at December 31, 2022 66 12,309 98 14,968 27,441 Primary Statements Consolidated Statements of Changes in Equity |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag081.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;81 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group These consolidated financial statements include Genmab A/S (parent company) and subsidiaries over which the parent company has control. The Genmab consolidated Group is referenced herein as "Genmab" or the "Company". This section describes Genmab's financial accounting policies including management's judgements and estimates under International Financial Reporting Standards (IFRS). New or revised EU endorsed accounting standards and interpretations are described, in addition to how these changes are expected to impact the financial performance and reporting of Genmab. Genmab describes the accounting policies in conjunction with each note with the aim to provide a more understandable description of each accounting area. ESEF Reporting Genmab is required to file the Annual Report in the European Single Electronic Format (ESEF) using the XHTML format and to tag the consoli-dated financial statements including notes using Inline eXtensible Business Reporting Language (iXBRL). The iXBRL tags comply with the ESEF taxonomy. Where a financial statement line item is not defined in the ESEF taxonomy, an extension to the taxonomy has been created. The annual report submitted to the Danish Financial Supervisory Authority consists of the XHTML document together with certain technical files, all included in a file named 529900MTJPDPE4MHJ122-2022-12-31-en.zip. 1.1 Nature of the Business and Accounting Policies Genmab A/S is a publicly traded, international biotechnology company that was founded in 1999 and specializes in the creation and devel-opment of differentiated antibody therapeutics for the treatment of cancer and other diseases. Genmab has five approved products commer-cialized by third parties, one approved product that is jointly commercialized with a collaboration partner, a broad clinical and pre-clinical product pipeline and proprietary next-generation antibody technologies. The consolidated financial statements have been prepared in accordance with IFRS as issued by the International Accounting Standards Board (IASB) and in accordance with IFRS as endorsed by the EU and further requirements in the Danish Financial Statements Act. The consoli-dated financial statements were approved by the Board of Directors and authorized for issue on February 22, 2023. Except as outlined in Note 1.2, the financial statements have been prepared using the same accounting policies as 2021. Please refer to the overview below to see in which note/section the detailed accounting policy is included. Section 2 Results for the Year 2.1 Revenue 2.2 Information about Geographical Areas 2.3 Staff Costs 2.4 Corporate and Deferred Tax 2.5 Profit per Share Section 3 Operating Assets and Liabilities 3.1 Intangible Assets 3.2 Property and Equipment 3.3 Leases 3.4 Other Investments 3.5 Receivables 3.7 Other Payables Section 4 Capital Structure, Financial Risk and Related Items 4.3 Financial Assets and Liabilities 4.4 Marketable Securities 4.5 Financial Income and Expenses 4.6 Share-Based Instruments Basis of Presentation Section 1 |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag082.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;82 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 1 Basis of Presentation \| 1.1 Nature of the Business and Accounting Policies Materiality Genmab's Annual Report is based on the concept of materiality and the Company focuses on information that is considered material and relevant to the users of the consolidated financial statements. The consolidated financial statements consist of a large number of trans-actions. These transactions are aggregated into classes according to their nature or function and presented in classes of similar items in the consol-idated financial statements as required by IFRS and the Danish Financial Statements Act. If items are individually immaterial, they are aggregated with other items of similar nature in the financial statements or in the notes. The disclosure requirements are substantial in IFRS and for Danish listed companies. Genmab provides these specific required disclosures unless the information is considered immaterial to the economic decision-making of the readers of the financial statements or not applicable. Consolidated Financial Statements The consolidated financial statements include Genmab A/S and subsidiaries over which the parent company has control. The parent controls a subsidiary when the parent is exposed to, or has rights to, variable returns from its involvement with the subsidiary and has the ability to affect those returns through its power to direct the activities of the subsidiary. Genmab A/S (parent company) holds invest-ments either directly or indirectly in the following subsidiaries: Name Domicile Ownership and votes 2022 Ownership and votes 2021 Genmab B.V. Utrecht, the Netherlands 100% 100% Genmab Holding B.V. Utrecht, the Netherlands 100% 100% Genmab US, Inc. New Jersey, USA 100% 100% Genmab K.K. Tokyo, Japan 100% 100% Genmab's consolidated financial statements have been prepared on the basis of the financial statements of the parent company and subsid-iaries—prepared under Genmab's accounting policies—by combining similar accounting items on a line-by-line basis. On consolidation, inter-company income and expenses, intercompany receivables and payables, and unrealized gains and losses on transactions between the consoli-dated companies are eliminated. The recorded value of the equity interests in the consolidated subsidiaries is eliminated with the proportionate share of the subsidiaries' equity. Subsidiaries are consolidated from the date when control is transferred to the Group. The income statements for subsidiaries with a different functional currency than Genmab's presentation currency are translated into Genmab's presentation currency at average exchange rates, and the balance sheets are trans-lated at the exchange rate in effect at the balance sheet date. Exchange rate differences arising from the trans-lation of foreign subsidiaries shareholders' equity at the beginning of the year and exchange rate differences arising as a result of foreign subsid-iaries' income statements being translated at average exchange rates are recorded in transla-tion reserves in shareholders' equity. Functional and Presentation Currency The financial statements have been prepared in Danish Kroner (DKK), which is the functional and presentation currency of the parent company. Foreign Currency Transactions in foreign currencies are translated at the exchange rates in effect at the date of the transaction. Exchange rate gains and losses arising between the transaction date and the settlement date are recognized in the income statement as financial income or expense. Unsettled monetary assets and liabilities in foreign currencies are translated at the exchange rates in effect at the balance sheet date. Exchange rate gains and losses arising between the trans-action date and the balance sheet date are recognized in the income statement as financial income or expense. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag083.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;83 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 1 Basis of Presentation \| 1.1 Nature of the Business and Accounting Policies Classification of Operating Expenses in the Income Statement Research and Development Expenses Research and development expenses primarily include salaries, benefits and other employee-related costs of Genmab's research and development staff, license costs, manufacturing costs, pre-clinical costs, clinical trials, contractors and outside service fees, amortization and impair-ment of licenses and rights related to intangible assets, depreciation of property and equipment, and depreciation of right-of-use assets, to the extent that such costs are related to the Group's research and development activities. Refer to Note 3.1 for a more detailed description on the treatment of Genmab's research and development expenses. Selling, General and Administrative Expenses Selling, general and administrative expenses relate to the management and administration of Genmab, including commercialization activities. This primarily includes salaries, benefits and other employee costs related to management and support functions including human resources, information technology and the finance depart-ments. In addition, depreciation of property and equipment and depreciation of right-of-use assets, to the extent such expenses are related to administrative functions, are also included. Selling, general and administrative expenses are recognized in the income statement in the period to which they relate. Statements of Cash Flows The cash flow statement is presented using the indirect method with basis in the net profit before tax. Cash flows from operating activities are stated as the net profit before tax adjusted for net financial items, non-cash operating items such as depreciation, amortization, impairment losses, share-based compensation expenses, provi-sions, and for changes in operating assets and liabilities, interest paid and received, interest elements of lease payments and corporate taxes paid or received. Operating assets and liabilities are mainly comprised of changes in receivables and other payables excluding the items included in cash and cash equivalents. Changes in non-current assets and liabilities are included in operating assets and liabilities, if related to the main revenue-producing activities of Genmab. Cash flows from investing activities consist of purchases and sales of marketable securities and other investments, as well as purchases of property and equipment. Cash flows from financing activities relate to the purchase of treasury shares, exercise of warrants, payments of withholding taxes on behalf of employees on net settled RSUs and payments of long-term loans including installments on lease liabilities. Cash and cash equivalents are comprised of cash, bank deposits, and marketable securities with a maturity of less than ninety days on the date of acquisition. The statements of cash flows cannot be derived solely from the financial statements. Treasury Shares The total amount paid to acquire treasury shares including directly attributable costs and the proceeds from the sale of treasury shares is recognized in retained earnings. Research Collaborations, License Agreements and Collaborative Agreements Research Collaborations and License Agreements Genmab continues to pursue the establishment of research collaborations and licensing agree-ments. These arrangements often include upfront payments, expense reimbursements or payments to the collaboration partner, and milestone and royalty arrangements, contingent upon the occurrence of certain future events linked to the success of the asset in development. In regard to Genmab's license agreements with Janssen, Novartis and Roche, each of these parties retain final decision-making authority over the relevant activities and as such no joint control exists. Refer to Note 2.1 for additional information related to revenue from these parties. Joint Collaborative Agreements Genmab has entered into a number of joint collab-orative agreements. These agreements often include upfront payments, expense reimburse-ments or payments to the collaboration partner, and milestone and royalty arrangements, contin-gent upon the occurrence of certain future events linked to the success of the asset in development. These agreements also provide Genmab with varying rights to develop, produce and market products together with its collaborative partners. Both parties in these arrangements share in the decision making and therefore have joint control of the arrangement. In 2022, Genmab's more significant collaboration agreements are with AbbVie (Epcoritamab), Seagen (Tisotumab vedotin) and BioNTech. Refer to Note 2.1 for additional information related to revenue from our joint collabora-tive agreements. Refer to Note 5.6 for detailed information regarding Genmab's significant Research Collaborations, License Agreements and Collaborative Agreements. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag084.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;84 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 1 Basis of Presentation \| 1.2 New Accounting Policies and Disclosures 1.2 New Accounting Policies and Disclosures New Accounting Policies and Disclosures for 2022 Genmab has, with effect from January 1, 2022, implemented the following standards and amendments: • Amendments to IFRS 3 Business Combinations; • Amendments to IAS 16 Property, Plant and Equipment; • Amendments to IAS 37 Provisions, Contingent Liabilities and Contingent Assets; and • Annual Improvements 2018–2020 All of the above amendments were issued on May 14, 2020. The implementation of these amendments did not have a material impact on the consolidated financial statements for the current or prior reporting periods and is not expected to have a significant impact in future reporting periods. New Accounting Policies and Disclosures Effective in 2023 or Later The IASB has issued a number of new standards and updated some existing standards, the majority of which are effective for accounting periods beginning on January 1, 2023 or later. Therefore, they are not incorporated in these consolidated financial statements. There are no standards presently known that are not yet effective and that would be expected to have a material impact on Genmab in current or future reporting periods and on foreseeable future transactions. 1.3 Management's Judgements and Estimates under IFRS In preparing financial statements under IFRS, certain provisions in the standards require management's judgements, including various accounting estimates and assumptions. These judgements and estimates affect the applica-tion of accounting policies, as well as reported amounts within the consolidated financial state-ments and disclosures. Determining the carrying amount of certain assets and liabilities requires judgements, estimates and assumptions concerning future events that are based on historical experience and other factors, which by their very nature are associated with uncertainty and unpredictability. Accounting estimates are based on historical experience and various other factors relative to the circumstances in which they are applied. Estimates are generally made based on informa-tion available at the time. Accounting judgements are made in the process of applying accounting policies. These judgements are typically made based on the guidance and information available at the time of application. These estimates and judgements may prove incomplete or incorrect, and unexpected events or circumstances may arise. Genmab is also subject to risks and uncertainties which may lead actual results to differ from these estimates, both positively and negatively. Specific risks for Genmab are discussed in the relevant section of this Annual Report and in the notes to the consoli-dated financial statements. The areas involving a high degree of judgement and estimation that are significant to the consol-idated financial statements are summarized below. Refer to the identified notes for further information on the key accounting estimates and judgements utilized in the preparation of the consolidated financial statements. Accounting Policy Key Accounting Estimates and Judgements Note Reference Estimation Risk Revenue Recognition Estimation of partner net sales amounts in the calculation of royalties Judgement in assessing the probability of attainment of milestones Estimation of variable consideration Judgement in assessing the nature of combined performance obligations within contracts Note 2.1 Moderate/ High Share Based Compensation Judgement in selecting assumptions required for valuation of warrant grants Note 4.6 Moderate Current and deferred income taxes Judgement and estimation regarding valuation of deferred income tax assets Estimation in developing the provision for any uncertain tax positions Note 2.4 Moderate Intangible assets Judgement in determining impairment of an intangible asset Note 3.1 Low |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag085.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;85 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Results for the Year This section includes disclosures related to revenue, information about geographical areas, staff costs, corporate and deferred tax and profit per share. A detailed description of the results for the year is provided in the Financial Review section in the Management's Review. Section 2 2.1 Revenue (DKK million) 2022 2021 2020 Revenue by type: Royalties 11,672 6,977 4,741 Reimbursement revenue 818 531 431 Milestone revenue 1,767 954 351 License revenue 6 – 4,588 Collaboration revenue 332 20 – Total 14,595 8,482 10,111 Revenue by collaboration partner: Janssen 10,620 6,847 4,693 AbbVie 1,174 245 4,398 Roche 796 603 305 Novartis 815 236 212 BioNTech 708 416 230 Seagen 413 135 201 Other 69 – 72 Total 14,595 8,482 10,111 Royalties by product: DARZALEX 10,056 6,135 4,419 TEPEZZA 796 593 298 Kesimpta 779 235 10 Other 41 14 14 Total 11,672 6,977 4,741 Accounting Policies Genmab recognizes revenue when its customer obtains control of promised goods or services, in an amount that reflects the consideration that it expects to receive in exchange for those goods or services. To determine revenue recognition for arrangements that Genmab determines are within the scope of IFRS 15, Genmab performs the following five steps: (i) identify the contract(s) with a customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when (or as) the entity satisfies a performance obligation. Genmab only applies the five-step model to contracts when it is probable that the Company will collect the consideration it is entitled to in exchange for the goods or services it transfers to the customer. At contract inception, once the contract is determined to be within the scope of IFRS 15, Genmab assesses the goods and services promised within each contract and iden - tifies as a performance obligation each good or service that is distinct. Revenue is recognized in the amount of the transaction price that is allocated to the respective performance obli - gation when (or as) the performance obligation is satisfied. Royalties: Certain of Genmab's license and collaboration agreements include sales-based royalties based on the level of sales. The license has been deemed to be the predominant item to which the royalties relate under Genmab's  |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag086.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;86 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 2 Results for the Year \| 2.1 Revenue license and collaboration agreements. As a result, Genmab recognizes revenue when the related sales occur. Reimbursement Revenue for R&D Services: Genmab's research collaboration agreements include the provisions for reimbursement or cost sharing for research and development services and payment for FTEs at contractual rates. R&D services are performed and satisfied over time given that the customer simultaneously receives and consumes the benefits provided by Genmab and revenue for research services is recognized over time rather than at a point in time. Milestone Revenue: Certain of Genmab's license and collaboration agreements include devel-opment, regulatory and commercial milestone payments based on the level of sales. At the inception of each arrangement that includes milestone payments, Genmab evaluates whether the achievement of milestones is considered highly probable and estimates the amount to be included in the transaction price using the most likely amount method. If it is highly probable that a significant revenue reversal would not occur, the associated milestone value is included in the transaction price. Milestone payments that are not within the control of Genmab or the license and collaboration partner, such as regulatory approvals, are not considered probable of being achieved until those approvals are received. The transaction price is then allocated to each perfor-mance obligation on a relative stand-alone selling price basis, for which Genmab recognizes revenue as or when the performance obligations under the contract are satisfied. At the end of each subse-quent reporting period, Genmab re-evaluates the probability of achievement of such development milestones and any related constraint, and if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative catch-up basis, which would affect revenue and earnings in the period of adjustment. Under all of Genmab's existing license and collaboration agreements, milestone payments have been allocated to the license transfer performance obligation. License Revenue for Intellectual Property: If the license to Genmab's functional intellectual property is determined to be distinct from the other performance obligations identified in the arrangement, Genmab recognizes revenues from non-refundable upfront fees allocated to the license at the point in time the license is trans-ferred to the licensee and the licensee is able to use and benefit from the license. For licenses that are bundled with other promises, Genmab utilizes judgement to assess the nature of the combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purposes of recognizing revenue from non-refundable, upfront fees. Under all of Genmab's existing license and collaboration agreements the license to functional intellectual property has been determined to be distinct from other perfor-mance obligations identified in the agreement. Collaboration Revenue: Collaboration revenue includes net profit sharing arrangements for the sale of commercial products. When Genmab is determined to be the principal in sales to end customers, all product sales are included in net product sales in the income statement. As of December 31, 2022, Genmab has not recorded any net product sales. When Genmab's collabo-ration partner is determined to be the principal in sales to end customers, Genmab's share of net profits for the sale of commercial products is included in collaboration revenue. Refer to Note 5.6 for detailed information regarding Genmab's significant Research Collaborations, License Agreements and Collaborative Agreements. Management's Judgements and Estimates—Revenue Recognition Evaluating the criteria for revenue recognition under license and collaboration agreements requires management's judgement to assess and determine the following: • An estimation of partner net sales amounts in determination of the calculation of royalties. • An assessment of whether the achievement of milestone payments is highly probable. • An estimation of variable consideration identified in the contract using key assumptions which may include forecasted revenues, development timelines, reimbursement rates for personnel costs, discount rates and probabilities of technical and regulatory success. • The nature of performance obligations and whether they are distinct or should be combined with other performance obligations to determine whether the performance obligations are satisfied over time or at a point in time. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag087.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;87 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 2 Results for the Year \| 2.2 Information about Geographical Areas 2.2 Information about Geographical Areas Genmab is managed and operated as one business unit, which is reflected in the organizational structure and internal reporting. No separate lines of business or separate business entities have been identified with respect to any licensed products, marketed products, product candidates or geograph-ical markets and no segment information is currently prepared for internal reporting. Accordingly, it has been concluded that it is not relevant to include segment disclosures in the financial statements as Genmab's business activities are not organized on the basis of differences in related product and geographical areas. Revenue Non-current assets Revenue Non-current assets Revenue Non-current assets (DKK million) 2022 2021 2020 Denmark 14,595 211 8,482 269 10,111 344 Netherlands – 793 – 422 – 380 United States – 442 – 470 – 370 Japan – 70 – 95 – – Total 14,595 1,516 8,482 1,256 10,111 1,094 Accounting Policies Geographical information is presented for Genmab's revenue and non-current assets. Revenue is attributed to countries on the basis of the location of the legal entity holding the contract with the counterparty. Non-current assets comprise intangible assets, property and equipment, right-of-use assets and receivables. 2.3 Staff Costs (DKK million) 2022 2021 2020 Wages and salaries 1,913 1,174 694 Share-based compensation 439 310 200 Defined contribution plans 112 80 51 Other social security costs 263 155 108 Government grants (144) (122) (119) Total 2,583 1,597 934 Staff costs are included in the income statement as follows: Research and development expenses 1,662 1,190 803 Selling, general and administrative expenses 1,065 529 250 Government grants related to research and development expenses (144) (122) (119) Total 2,583 1,597 934 Average number of FTE 1,460 1,022 656 Number of FTE at year-end 1,660 1,212 781 Refer to Note 4.6 for additional information regarding share-based instruments and Note 5.1 for additional information regarding the remuneration of the Board of Directors and Executive Management. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag088.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;88 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 2 Results for the Year \| 2.4 Corporate and Deferred Tax Accounting Policies Staff Costs Wages and salaries, other social security costs, paid leave and bonuses, and other employee benefits are recognized in the financial year in which the employee performs the associ-ated work. Genmab's pension plans are classified as defined contribution plans and, accordingly, no pension obligations are recognized in the balance sheet. Costs relating to defined contribution plans are included in the income statement in the period in which they are accrued, and outstanding contribu-tions are included in other payables. Termination benefits are recognized as an expense, when Genmab is committed demonstrably, without realistic possibility of withdrawal, to a formal detailed plan to terminate employment. Government Grants The Dutch Research and Development Act "WBSO" provides compensation for a part of research and development wages and other costs through a reduction in payroll taxes. WBSO grant amounts are offset against wages and salaries and included in research and development expenses in the income statement. 2.4 Corporate and Deferred Tax Taxation—Income Statement & Shareholders' Equity (DKK million) 2022 2021 2020 Current tax on profit 1,498 968 1,191 Adjustment to deferred tax 107 (371) (112) Adjustment to unrecognized deferred tax assets (92) 378 67 Total tax for the period in the income statement 1,513 975 1,146 (DKK million) 2022 2021 2020 Net profit before tax 7,035 3,983 5,904 Tax at the Danish corporation tax rate of 22% for all periods 1,548 876 1,299 Tax effect of: Adjustment to unrecognized deferred tax assets (92) 137 67 Recognition of previously unrecognized tax losses and deductible temporary differences (12) 119 (222) Non-deductible expenses/non-taxable income and other permanent differences, net 73 (147) (5) All other (4) (10) 7 Total tax effect (35) 99 (153) Total tax for the period in the income statement 1,513 975 1,146 Total tax for the period in shareholders' equity (22) (31) (44) Effective Tax Rate 21.5% 24.5% 19.4% Corporate tax consists of current tax and the adjustment of deferred taxes during the year. The corporate tax expense was DKK 1,513 million in 2022, DKK 975 million in 2021 and DKK 1,146 million in 2020. Tax expenses of DKK 22 million, DKK 31 million, and DKK 44 million related to excess tax benefits for share-based compensation were recorded directly in shareholders' equity, in 2022, 2021, and 2020, respectively. Taxation—Balance Sheet Significant components of the deferred tax asset are as follows: (DKK million) 2022 2021 Share-based instruments 128 136 Deferred revenue 113 113 Other temporary differences 11 15 Total Deferred Taxes 252 264 Genmab recognizes deferred tax assets if it is probable that sufficient taxable income will be available in the future, against which the temporary differences and unused tax losses can be utilized. Management has considered future taxable income and applied its judgement in assessing whether deferred tax assets should be recognized. As of December 31, 2022, and 2021, Genmab had gross tax loss carryforwards of DKK 3.2 billion and DKK 2.7 billion, respectively, to reduce future taxable income in the U.S. and the Netherlands. The loss carryforwards generally expire in various periods through 2037; however, U.S. tax losses originating after 2017 and tax losses in the Netherlands available as of December 31, 2022, can be carried forward indefinitely. Accounting Policies Corporate Tax Corporate tax, which consists of current tax and deferred taxes for the year, is recognized in the income statement, except to the extent that the  |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag089.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;89 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 2 Results for the Year \| 2.5 Profit Per Share tax is attributable to items which directly relate to shareholders' equity or other comprehen-sive income. Current tax assets and liabilities for current and prior periods are measured at the amounts expected to be recovered from or paid to the tax authorities. Deferred Tax Deferred tax accounting requires recognition of deferred tax on all temporary differences between the carrying amount of assets and liabilities and the tax base of such assets and liabilities. This includes the tax value of certain tax losses carried forward. Deferred tax is calculated in accordance with the tax regulations in the local countries and the tax rates expected to be in force at the time the deferred tax is utilized. Changes in deferred tax as a result of changes in tax rates are recognized in the income statement. Deferred tax assets resulting from temporary differences, including the tax value of losses to be carried forward, are recognized only to the extent that it is probable that future taxable profit will be available against which the differences can be utilized. Management's Judgements and Estimates Deferred Tax Genmab recognizes deferred tax assets if management assesses that these tax assets can be offset against positive taxable income within a foreseeable future. This judgement is made on an ongoing basis and is based on numerous factors, including actual results, budgets and business plans for the coming years. Realization of deferred tax assets is dependent upon a number of factors, including future taxable earnings, the timing and amount of which are highly uncertain. A significant portion of Genmab's future taxable income will be driven by future events that are highly susceptible to factors outside the control of Genmab including commercial growth of DARZALEX, specific clinical outcomes, regulatory approvals, advancement of Genmab's product pipeline and other matters. Genmab continues to maintain nonrecognition of a significant portion of deferred tax assets related to its subsidiaries until there is sufficient evidence to support the recognition of deferred tax assets. Genmab may recognize deferred tax assets related to its subsidiaries in the future. The recognition of deferred tax assets will result in a decrease to income tax expense in such period. 2.5 Profit Per Share (DKK million) 2022 2021 2020 Net profit 5,522 3,008 4,758 (Shares) Average number of shares outstanding 65,783,130 65,634,300 65,315,975 Average number of treasury shares (395829) (238663) (136969) Average number of shares excl. treasury shares 65,387,301 65,395,637 65,179,006 Average number of share-based instruments, dilution 622,303 650,114 706,869 Average number of shares, diluted 66,009,604 66,045,751 65,885,875 Basic net profit per share 84.45 46.00 73.00 Diluted net profit per share 83.65 45.54 72.21 In the calculation of the diluted net profit per share for 2022, 68,728 warrants (none of which were vested) have been excluded as these share-based instruments are out of the money, compared to 43,654 and 68,605 (none of which were vested) for 2021 and 2020, respectively. Accounting Policies Basic Net Profit per Share Basic net profit per share is calculated as the net profit for the period divided by the weighted average number of outstanding ordinary shares, excluding treasury shares. Diluted Net Profit per Share Diluted net profit per share is calculated as the net profit for the period divided by the weighted average number of outstanding ordinary shares, excluding treasury shares and adjusted for the dilutive effect of share equivalents. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag090.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;90 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Operating Assets and Liabilities This section covers the operating assets and related liabilities that form the basis for Genmab's activities. Deferred tax assets and liabilities are included in Note 2.4. Assets related to Genmab's financing activities are shown in section 4. Section 3 3.1 Intangible Assets Licenses, Rights, and Patents (DKK million) 2022 2021 Cost at January 1 891 891 Cost at December 31 891 891 Accumulated amortization and impairment at January 1 (637) (553) Amortization for the year (70) (84) Impairment for the year (38) – Accumulated amortization and impairment at December 31 (745) (637) Carrying amount of Intangible Assets at December 31 146 254 (DKK million) 2022 2021 2020 Amortization and impairment included in the income statement as follows: Research and development expenses 108 84 131 Total 108 84 131 Accounting Policies Research and Development Projects Internal and subcontracted research costs are charged in full to the income statement in the period in which they are incurred. Consistent with industry practice, development costs are also expensed until regulatory approval is obtained or is probable. Genmab has no internally generated intangible assets from development, as the criteria for recognition of an intangible asset are not met. Licenses and Rights Genmab acquires licenses and rights primarily to gain access to targets and technologies iden-tified by third parties. Payments to third parties under collaboration and license agreements are assessed to determine whether such payments should be expensed as incurred as research and development expenses or capitalized as an intan-gible asset. Licenses and rights that meet the criteria for capitalization as intangible assets are measured at cost less accumulated amortization and any impairment losses. Milestone payments related to capitalized licenses and rights are accounted for as an increase in the cost to acquire licenses and rights. Amortization Amortization is based on the straight-line method over the estimated useful life. This corresponds to the legal duration or the economic useful life depending on which is shorter. The amortization  |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag091.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;91 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 3 Operating Assets and Liabilities \| 3.2 Property and Equipment of intellectual property rights commences after regulatory approval has been obtained or when assets are put in use. Management's Judgements and Estimates Impairment If circumstances or changes in Genmab's operations indicate that the carrying amount of intangible assets may not be recoverable, management reviews the asset for impairment. The basis for the review is the recoverable amount of the intangible assets, determined as the greater of the fair value less cost to sell or its value in use. Value in use is calculated as the net present value of future cash inflow generated from the intangible asset. If the carrying amount of an intangible asset is greater than the recover-able amount, the intangible asset is written down to the recoverable amount. An impairment loss is recognized in the income statement when the impairment is identified. Impairments on intan-gible assets are reviewed at each reporting date for possible reversal. Amortization, impairment losses, and gains or losses on the disposal of intangible assets related to licenses and rights are recognized in the income statement as research and develop-ment expenses. 3.2 Property and Equipment (DKK million) Leasehold improvements Equipment, furniture and fixtures Assets under construction Total property and equipment 2022 Cost at January 1 400 537 52 989 Additions for the year 5 118 181 304 Disposals for the year (8) (13) – (21) Exchange rate adjustment 15 7 – 22 Cost at December 31 412 649 233 1,294 Accumulated depreciation and impairment at January 1 (90) (278) – (368) Depreciation for the year (52) (94) – (146) Exchange rate adjustment (1) (2) – (3) Accumulated depreciation on disposals 11 11 – 22 Accumulated depreciation and impairment at December 31 (132) (363) – (495) Carrying amount at December 31 280 286 233 799 2021 Cost at January 1 287 416 14 717 Additions for the year 29 120 111 260 Transfers between the classes 70 3 (73) – Disposals for the year – (9) – (9) Exchange rate adjustment 14 7 – 21 Cost at December 31 400 537 52 989 Accumulated depreciation and impairment at January 1 (43) (221) – (264) Depreciation for the year (46) (64) – (110) Exchange rate adjustment (1) (2) – (3) Accumulated depreciation on disposals – 9 – 9 Accumulated depreciation and impairment at December 31 (90) (278) – (368) Carrying amount at December 31 310 259 52 621 (DKK million) 2022 2021 2020 Depreciation and impairment included in the income statement as follows: Research and development expenses 108 93 69 Selling, general and administrative expenses 38 17 10 Total 146 110 79 Capital expenditures in 2022 and 2021 were primarily related to the expansion of our facilities in the Netherlands and the U.S. to support the growth in our product pipeline. Accounting Policies Property and equipment is comprised of leasehold improvements, assets under construc-tion, and equipment, furniture and fixtures, which are measured at cost less accumulated deprecia-tion and any impairment losses. The cost is comprised of the acquisition price and direct costs related to the acquisition until the asset is ready for use. Costs include direct costs and costs to subcontractors. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag092.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;92 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 3 Operating Assets and Liabilities \| 3.3 Leases Depreciation Depreciation is calculated on a straight-line basis to allocate the cost of the assets, net of any residual value, over the estimated useful lives, which are as follows: Equipment, furniture and fixtures 3–5 years Computer equipment 3 years Leasehold improvements 15 years or the lease term, if shorter Depreciation commences when the asset is available for use, including when it is in the location and condition necessary for it to be capable of operating in the manner intended by management. The useful lives and residual values are reviewed and adjusted if appropriate on a yearly basis. Assets under construction are not depreciated. Impairment If circumstances or changes in Genmab's oper-ations indicate that the carrying amount of property and equipment may not be recoverable, management reviews the asset for impairment. The basis for the review is the recoverable amount of the asset, determined as the greater of the fair value less cost to sell or its value in use. Value in use is calculated as the net present value of future cash inflow generated from the asset. If the carrying amount of an asset is greater than the recoverable amount, the asset is written down to the recoverable amount. An impairment loss is recognized in the income statement when the impairment is identified. 3.3 Leases Genmab has entered into lease agreements with respect to office and laboratory space, and IT equipment. The expense, lease liability, and right-of-use assets balances related to IT equipment are immaterial. The leases are non-cancellable over various periods through 2038. (DKK million) December 31, 2022 December 31, 2021 December 31, 2020 Right-of-use assets Balance at January 1 354 283 177 Additions to right-of-use assets1 243 127 142 Depreciation charge for the year (74) (56) (36) Balance at December 31 523 354 283 Lease liabilities Current 74 62 42 Non-current 523 363 277 Total lease liabilities 597 425 319 Cash outflow for lease payments 88 70 53 1. Additions to right-of-use assets also includes modifications to existing leases and adjustments to the provisions for contractual restoration obligations related to leases of Genmab offices. Variable lease payments, short-term leases, lease interest expense, and sublease income are immaterial. Future minimum payments under leases as of December 31, 2022, December 31, 2021, and December 31, 2020, are as follows: (DKK million) 2022 2021 2020 Payment due Less than 1 year 89 74 53 1 to 3 years 167 109 85 More than 3 years but less than 5 years 136 97 62 More than 5 years 271 207 194 Total 663 487 394 Future minimum payments under our leases with commencement dates after December 31, 2022 are not included in the table above. Significant Leases Not Yet Commenced During 2020, Genmab entered into a lease agreement with respect to the new headquarters in Denmark with a commencement date in March 2023 and is non-cancellable until March 2038. The total future minimum payments over the term of the lease are approximately DKK 339 million and estimated capital expenditures to fit out the space are approximately DKK 128 million. Accounting Policies All leases are recognized in the balance sheet as a right-of-use ("ROU") asset with a corre-sponding lease liability, except for short-term leases in which the term is 12 months or less, or low-value leases. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag093.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;93 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 3 Operating Assets and Liabilities \| 3.4 Other Investments ROU assets represent Genmab's right to use an underlying asset for the lease term and lease liabilities represent Genmab's obligation to make lease payments arising from the lease. The ROU asset is depreciated over the shorter of the asset's useful life or the lease term on a straight-line basis. In the income statement, lease costs are replaced by depreciation of the ROU asset recog-nized over the lease term in operating expenses, and interest expenses related to the lease liability are classified in financial items. Genmab determines if an arrangement is a lease at inception. Genmab leases various properties and IT equipment. Rental contracts are typically made for fixed periods. Lease terms are negoti-ated on an individual basis and contain a wide range of terms and conditions. Assets and liabilities arising from a lease are initially measured on a present value basis. Lease liabilities include the net present value of fixed payments, less any lease incentives. As Genmab's leases generally do not provide an implicit interest rate, Genmab uses an incremental borrowing rate based on the information available at the commencement date of the lease in determining the present value of lease payments. Lease terms utilized by Genmab may include options to extend or terminate the lease when it is reasonably certain that Genmab will exercise that option. In determining the lease term, management considers all facts and circumstances that create an economic incentive to exercise an extension option, or not exercise a termination option. Extension options (or periods after termination options) are only included in the lease term if the lease is reasonably certain to be extended. ROU assets are measured at cost and include the amount of the initial measurement of the lease liability, any lease payments made at or before the commencement date less any lease incentives received, any initial direct costs, and restoration costs. Payments associated with short-term leases and leases of low-value assets are recognized on a straight-line basis as an expense in the income statement. 3.4 Other Investments (DKK million) December 31, 2022 December 31, 2021 Publicly traded equity securities 67 344 Fund investments 66 27 Total other investments 133 371 Other investments include investments in publicly traded common stock of companies, including common stock of companies with whom Genmab has entered into collaboration arrangements, as well as investments in certain strategic investment funds. The decrease in other investments was primarily driven by the decrease in fair value of Genmab's investment in common shares of CureVac N.V. ("CureVac"). Accounting Policies Other investments are measured on initial recog-nition at fair value, and subsequently at fair value. Changes in fair value are recognized in the income statement within financial income or expense. 3.5 Receivables (DKK million) 2022 2021 Receivables related to collaboration agreements 5,266 2,979 Interest receivables 82 37 Other receivables 176 160 Receivables for securities matured 290 – Prepayments 144 218 Total at December 31 5,958 3,394 Non-current receivables 48 27 Current receivables 5,910 3,367 Total at December 31 5,958 3,394 During 2022 and 2021, there were no losses related to receivables and the credit risk on receiv-ables is considered to be limited. The provision for expected credit losses was not significant given that there have been no credit losses over the last three years and the high-quality nature (top tier life science companies) of Genmab's customers are not likely to result in future default risk. The receivables are mainly comprised of royalties, milestones and amounts due under collaboration agreements and are non-interest bearing receiv-ables which are due less than one year from the balance sheet date. Refer to Note 4.2 for additional information about interest receivables and related credit risk. Accounting Policies Receivables are designated as financial assets measured at amortized cost and are initially measured at fair value or transaction price and subsequently measured in the balance sheet at amortized cost, which generally corresponds to nominal value less expected credit losses. Genmab utilizes a simplified approach to measuring expected credit losses and uses a lifetime expected loss allowance for all receiv-ables. To measure the expected credit losses, receivables have been grouped based on credit risk characteristics and the days past due. Prepayments include expenditures related to a future financial period. Prepayments are measured at nominal value. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag094.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;94 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 3 Operating Assets and Liabilities \| 3.6 Deferred Revenue 3.6 Deferred Revenue Genmab has recognized the following liabilities related to the AbbVie collaboration agreement. (DKK million) 2022 2021 Deferred revenue at January 1 513 513 Payment received – – Revenue recognized during the year – – Total at December 31 513 513 Non-current deferred revenue 480 487 Current deferred revenue 33 26 Total at December 31 513 513 Deferred revenue was recognized in connec-tion with the AbbVie collaboration agreement. An upfront payment of USD 750 million (DKK 4,911 million) was received in July 2020 of which DKK 4,398 million was recognized as license revenue during 2020. The revenue deferred at the initiation of the AbbVie agreement in June 2020 related to four product concepts to be identified and controlled under a research agreement to be negotiated between Genmab and AbbVie. One of the product concepts will comprise of or contain Genmab antibodies conjugated with AbbVie's payload linker technology and the other three product concepts will comprise of or contain CD3 DuoBody bispecific antibodies and AbbVie propri-etary antibodies. During the first quarter of 2022, Genmab and AbbVie entered into the aforementioned research agreement that governs the research and development activities in regard to the product concepts. As of December 31, 2022, two of the four product concepts have been selected for research and development. As part of the continued evalua-tion of deferred revenue related to the AbbVie collaboration agreement, Genmab's classification of deferred revenue reflects the current estimate of co-development activities related to these product concepts as of December 31, 2022. None of the deferred revenue was recognized as reim-bursement revenue in 2022, 2021 or 2020. Refer to Note 2.1 for additional information related to the AbbVie collaboration. 3.7 Other Payables (DKK million) 2022 2021 Liabilities related to collaboration agreements 70 53 Staff cost liabilities 481 296 Other liabilities 919 781 Provisions 12 13 Accounts payable 245 350 Total at December 31 1,727 1,493 Non-current other payables 11 13 Current other payables 1,716 1,480 Total at December 31 1,727 1,493 Accounting Policies Other payables, excluding provisions, are initially measured at fair value and subsequently measured in the balance sheet at amortized cost. The current other payables are comprised of liabilities that are due less than one year from the balance sheet date and are in general not interest bearing and settled on an ongoing basis during the next financial year. Non-current payables are measured at the present value of the expenditures expected to be required to settle the obligation using a pre-tax discount rate that reflects current market assessments of the time value of money and the risks specific to the obligation. The increase in the liability due to passage of time is recognized as interest expense. Accounts Payable Accounts payable are measured in the balance sheet at amortized cost. Other Liabilities Other liabilities primarily include accrued expenses related to our research and develop-ment project costs. Refer to Note 2.3 for accounting policies related to staff costs. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag095.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;95 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group 4.1 Capital Management Genmab's goal is to maintain a strong capital base so as to maintain investor, creditor and market confidence, and a continuous advancement of Genmab's product pipeline and business in general. Genmab is primarily financed through revenues under various collaboration agreements and had, as of December 31, 2022, cash and cash equivalents of DKK 9,893 million and marketable securities of DKK 12,431 million compared to DKK 8,957 million and DKK 10,381 million, respec-tively, as of December 31, 2021. Genmab's cash and cash equivalents and marketable securities support the advancement of our product pipeline and operations. The adequacy of our available funds will depend on many factors, including the level of DARZALEX and other royalty streams, progress in our research and development programs, the magnitude of those programs, our commitments to existing and new clinical collaborators, our ability to establish commercial and licensing arrangements, our capital expenditures, market developments, and any future acquisitions. Accordingly, Genmab may require additional funds and may attempt to raise additional funds through equity or debt financings, collaborative agree-ments with partners, or from other sources. The Board of Directors monitors the share and capital structure to ensure that Genmab's capital resources support its strategic goals. Neither Genmab A/S nor any of its subsid-iaries are subject to externally imposed capital requirements. 4.2 Financial Risk The financial risks of the Genmab Group are managed centrally. The overall risk management guidelines have been approved by the Board of Directors and include the Group's investment policy related to our marketable securities. The Group's risk management guidelines are established to identify and analyze the risks faced by the Genmab Group, to set the appropriate risk limits and controls and to monitor the risks and adherence to limits. It is Genmab's policy not to actively speculate in financial risks. The Group's financial risk management is directed solely towards monitoring and reducing financial risks which are directly related to Genmab's operations. The primary objective of Genmab's investment activities is to preserve capital and ensure liquidity with a secondary objective of maximizing the return derived from security investments without significantly increasing risk. Therefore, our investment policy includes among other items, guidelines and ranges for which invest-ments (which are primarily shorter-term in nature) are considered to be eligible investments for Genmab and which investment parameters are to be applied, including maturity limitations and credit ratings. In addition, the policy includes specific diversification criteria and investment limits to minimize the risk of loss resulting from over concentration of assets in a specific class, issuer, currency, country, or economic sector. Genmab's marketable securities are adminis-trated by external investment managers. The investment guidelines and managers are reviewed regularly to reflect changes in market conditions, Genmab's activities and financial position. At the beginning of 2021, Genmab's investment policy was amended to allow investments in debt rated BBB- or greater by S&P or Fitch and in debt rated Baa3 or greater by Moody's. The amended policy also includes additional allowable investment types such as corporate debt, commercial paper, certificates of deposit, and certain types of AAA rated asset-backed securities. In addition to the capital management and financing risk mentioned in Note 4.1, Genmab has identified the following key financial risk areas, which are mainly related to our marketable securi-ties portfolio: • credit risk; • foreign currency risk; and • interest rate risk All of Genmab's marketable securities are traded in established markets. Given the current market conditions, all future cash inflows including re-investments of proceeds from the disposal of Capital Structure, Financial Risk and Related Items This section includes disclosures related to how Genmab manages its capital structure, cash position and related risks and items. Genmab is primarily financed through partnership collaborations. Section 4 |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag096.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;96 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 4 Capital Structure, Financial Risk and Related Items \| 4.2 Financial Risk marketable securities are invested in highly liquid, investment grade securities. Refer to Note 4.4 for additional information regarding market-able securities. Credit Risk Genmab is exposed to credit risk and losses on marketable securities and bank deposits. The maximum credit exposure related to Genmab's cash and cash equivalents and marketable securi-ties was DKK 22,324 million as of December 31, 2022 compared to DKK 19,338 million as of December 31, 2021. The maximum credit exposure to Genmab's receivables was DKK 5,958 million as of December 31, 2022 compared to DKK 3,394 million as of December 31, 2021. Marketable Securities To manage and reduce credit risks on our securi-ties, Genmab's policy is to ensure only securities from investment grade issuers are eligible for our portfolios. No issuer of marketable securities can be accepted if the issuer, at the time of purchase, does not have the credit quality equal to or better than the rating shown in the table below from at least one of the rating agencies. If an issuer is rated by more than one of the rating agencies listed below, the credit assessment is made against the lowest rating available for the issuer. Category S&P Moody's Fitch Short-term A-2 P-2 F-2 Long-term BBB- Baa3 BBB-Genmab's current portfolio is spread over a number of different securities with a focus on liquidity and security. As of December 31, 2022, 75% of Genmab's marketable securities were long-term A rated or higher, or short-term A-1/P-1 rated by S&P, Moody's or Fitch compared to 68% as of December 31, 2021. The total value of marketable securities amounted to DKK 12,431 million at the end of 2022 compared to DKK 10,381 million at the end of 2021. Cash and Cash Equivalents To reduce the credit risk on our bank deposits, Genmab's policy is only to invest its cash deposits with highly rated financial institutions. Currently, these financial institutions have a short-term Fitch and S&P rating of at least F-1 and A-1, respectively. In addition, Genmab maintains bank deposits at a level necessary to support the short-term funding requirements of Genmab. The total value of bank deposits including AAA rated money market funds and short-term marketable secu-rities classified as cash equivalents amounted to DKK 9,893 million as of December 31, 2022 compared to DKK 8,957 million at the end of 2021. The increase was primarily driven by Genmab's increased profitability and foreign exchange movements which positively impacted our USD denominated cash and cash equivalents. Receivables The credit risk related to our receivables is not significant based on the high-quality nature of Genmab's collaboration partners. As disclosed in Note 2.1, Janssen, Roche, AbbVie and BioNTech are Genmab's primary partners in which receivables are established for royalties, milestone revenue and reimbursement revenue. Foreign Currency Risk Genmab's presentation currency is the DKK; however, Genmab's revenues and expenses are in a number of different currencies. Consequently, there is a substantial risk of exchange rate fluctu-ations having an impact on Genmab's cash flows, profit (loss) and/or financial position in DKK. The majority of Genmab's revenue is generated in USD. Exchange rate changes to the USD will result in changes to the translated value of future net profit before tax and cash flows. Genmab's revenue in USD was 89% of total revenue in 2022 as compared to 92% in 2021 and 95% in 2020. Under our license agreement with Janssen for DARZALEX, for purposes of calculating royalties due to Genmab, DARZALEX net sales for non-U.S. dollar denominated currencies are translated to U.S. dollars at a specified annual Currency Hedge Rate. Movements in foreign exchanges against the annual Currency Hedge Rate will result in changes to royalties due to Genmab impacting net profit before tax and cash flows. There is also exposure that exchange rate fluctu-ations may impact equity as part of the currency translation adjustments required to convert the investments in foreign subsidiaries from their respective functional currencies to the presen-tation currency during consolidation, however any such fluctuations would be immaterial. The foreign subsidiaries are not significantly affected by currency risks as both revenues and expenses are primarily settled in the foreign subsidiaries' functional currencies. Assets and Liabilities in Foreign Currency Genmab's marketable securities denominated in USD, DKK, EUR and GBP as a percentage of total marketable securities were as follows: Percent December 31, 2022 December 31, 2021 USD 80% 75% DKK 12% 16% EUR 7% 8% GBP 1% 1% Total 100% 100% Genmab's USD currency exposure is mainly related to cash and cash equivalents, marketable securities, and receivables related to our collabo-rations with Janssen, AbbVie, Roche and Seagen. Significant changes in the exchange rate of USD to DKK could cause net profit before tax to change materially as gains and losses are recognized in the income statement. Based on the amount of assets and liabilities denominated in USD as of December 31, 2022 and 2021, a 10% increase/ decrease in the USD to DKK exchange rate is estimated to impact Genmab's net profit before tax by approximately DKK 2.2 billion and DKK 1.5 billion, respectively. The analysis assumes that all other variables, in particular interest rates, remain constant. The movements in the income statement and equity arise from monetary items (cash and cash equivalents, marketable securities, receivables and liabilities) where the  |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag097.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;97 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 4 Capital Structure, Financial Risk and Related Items \| 4.3 Financial Assets and Liabilities functional currency of the entity differs from the currency that the monetary items are denomi-nated in. Genmab's EUR exposure is mainly related to our marketable securities, receivables under our collaboration with BioNTech, and other costs denominated in EUR. Since the introduction of the EUR in 1999, Denmark has committed to maintaining a central rate of 7.46 DKK to the EUR. This rate may fluctuate within a +/- 2.25% band. Should Denmark's policy toward the EUR change, the DKK values of our EUR denominated assets and costs could be materially different compared to what is calculated and reported under the existing Danish policy toward the DKK/EUR. As of December 31, 2022 and 2021, Genmab's EUR exposure is not material. Genmab's GBP currency exposure is mainly related to contracts and marketable securi-ties denominated in GBP. As of December 31, 2022 and 2021, Genmab's GBP exposure is not material. Interest Rate Risk Genmab's exposure to interest rate risk is primarily related to marketable securities, as Genmab currently does not have significant interest-bearing debts. Marketable Securities The securities in which the Group has invested bear interest rate risk, as a change in market-derived interest rates may cause fluctuations in the fair value of the investments. In accordance with the objective of the investment activities, the portfolio of securities is monitored on a total return basis. To control and minimize the interest rate risk, Genmab maintains an investment portfolio in a variety of securities with a relatively short effective duration with both fixed and variable interest rates. A sensitivity analysis was performed on Genmab's marketable securities, and based on exposures in 2021 and 2022, a hypothetical +/- 1% interest rate change would not have resulted in a material change in the fair values of these financial instru-ments. Due to the short-term nature of the current investments and to the extent that Genmab is able to hold the investments to maturity, the current exposure to changes in fair value due to interest rate changes is considered to be insignificant compared to the fair value of the portfolio. (DKK million) 2022 2021 Year of Maturity 2022 – 3,372 2023 6,254 3,041 2024 3,660 2,654 2025 1,801 448 2026 219 152 2027+ 497 714 Total 12,431 10,381 4.3 Financial Assets and Liabilities Categories of Financial Assets and Liabilities (DKK million) Note 2022 2021 Financial assets measured at fair value through profit or loss Marketable securities 4.4 12,431 10,381 Other investments 3.4 133 371 Financial assets measured at amortized cost Receivables excluding prepayments 3.5 5,814 3,176 Cash and cash equivalents 9,893 8,957 Financial liabilities measured at amortized cost: Other payables excluding provisions 3.7 (1715) (1480) Lease liabilities 3.3 (597) (425) Fair Value Measurement 2022 2021 (DKK million) Note Level 1 Level 2 Level 3 Total Level 1 Level 2 Level 3 Total Assets Measured at Fair Value Marketable securities 4.4 12,431 – – 12,431 10,381 – – 10,381 Other investments 3.4 67 – 66 133 344 – 27 371 |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag098.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;98 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 4 Capital Structure, Financial Risk and Related Items \| 4.3 Financial Assets and Liabilities Marketable Securities Substantially all fair market values are determined by reference to external sources using unadjusted quoted prices in established markets for our marketable securities (Level 1). Other Investments The fair value of Genmab's investment in CureVac is determined using unadjusted quoted prices in established markets (Level 1). There were no transfers into or out of Level 3 during 2021 or 2022. Acquisitions (capital calls) on Level 3 investments in 2021 and 2022 were as follows: (DKK million) Other Investments Fair value at December 31, 2020 14 Acquisitions 13 Fair value at December 31, 2021 27 Acquisitions 39 Fair value at December 31, 2022 66 Accounting Policies Classification of Categories of Financial Assets and Liabilities Genmab classifies its financial assets held into the following measurement categories: • those to be measured subsequently at fair value (either through other comprehensive income, or through profit or loss), and • those to be measured at amortized cost. The classification depends on the business model for managing the financial assets and the contrac-tual terms of the cash flows. For assets measured at fair value, gains and losses will either be recorded in profit or loss or other comprehensive income. Genmab reclassifies debt investments only when its business model for managing those assets changes. Further details about the accounting policy for each of the categories are outlined in the respec-tive notes. Fair Value Measurement Genmab measures financial instruments, such as marketable securities, at fair value at each balance sheet date. Management assessed that the fair value of financial assets and liabil-ities measured at amortized cost such as bank deposits, receivables and other payables approx-imate their carrying amounts largely due to the short-term maturities of these instruments. Fair value is the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. The fair value measure-ment is based on the presumption that the transaction to sell the asset or transfer the liability takes place either: • In the principal market for the asset or liability, or • In the absence of a principal market, in the most advantageous market for the asset or liability. The principal or the most advantageous market must be accessible by Genmab. The fair value of an asset or a liability is measured using the assumptions that market participants would use when pricing the asset or liability, assuming that market participants act in their economic best interest. Genmab uses valuation techniques that are appropriate in the circumstances and for which sufficient data are available to measure fair value, maximizing the use of relevant observable inputs and minimizing the use of unobservable inputs. For financial instruments that are measured in the balance sheet at fair value, IFRS 13 requires disclosure of fair value measurements by level of the following fair value measurement hierarchy: • Level 1—Quoted prices (unadjusted) in active markets for identical assets or liabilities • Level 2—Inputs other than quoted prices included within level 1 that are observable for the asset or liability, either directly (that is, as prices) or indirectly (that is, derived from prices) • Level 3—Inputs for the asset or liability that are not based on observable market data (that is, unobservable inputs). For assets and liabilities that are recognized in the financial statements on a recurring basis, Genmab determines whether transfers have occurred between levels in the hierarchy by re-assessing categorization (based on the lowest level input that is significant to the fair value measurement as a whole) at the end of each reporting period. Any transfers between the different levels are carried out at the end of the reporting period. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag099.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;99 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 4 Capital Structure, Financial Risk and Related Items \| 4.4 Marketable Securities 4.4 Marketable Securities (DKK million) Market value 2022 Share % Market value 2021 Share % USD portfolio Corporate bonds 5,091 41% 5,149 50% US government bonds and treasury bills 3,067 25% 1,496 14% Commercial paper 807 6% 528 5% Other 1,023 8% 608 6% Total USD portfolio 9,988 80% 7,781 75% DKK portfolio Kingdom of Denmark bonds and treasury bills 442 3% 460 4% Danish mortgage-backed securities 1,093 9% 1,203 12% Total DKK portfolio 1,535 12% 1,663 16% EUR portfolio European government bonds and treasury bills 832 7% 856 8% GBP portfolio UK government bonds and treasury bills 76 1% 81 1% Total portfolio 12,431 100% 10,381 100% Marketable securities 12,431 10,381 Refer to Note 4.2 for additional information regarding the risks related to our marketable securities. Accounting Policies Marketable securities consist of investments in securities with a maturity of ninety days or greater at the time of acquisition. Measurement of market-able securities depends on the business model for managing the asset and the cash flow charac-teristics of the asset. There are two measurement categories into which Genmab classifies its debt instruments: • Amortized cost: Assets that are held for collection of contractual cash flows, where those cash flows represent solely payments of principal and interest, are measured at amortized cost. Interest income from these financial assets is included in finance income using the effective interest rate method. Any gain or loss arising on derecognition is recognized directly in profit or loss and presented in other gains/(losses), together with foreign exchange gains and losses. Impairment losses are presented as a separate line item in the statement of profit or loss. • Fair value through profit and loss (FVPL): Assets that do not meet the criteria for amortized cost or fair value through other comprehensive income (FVOCI) are measured at FVPL. A gain or loss on a debt investment that is subsequently measured at FVPL is recognized in profit or loss and presented net within financial income or expenses in the period in which it arises. Genmab's portfolio is managed and evaluated on a fair value basis in accordance with its stated investment guidelines and the information provided internally to management. This business model does not meet the criteria for amortized cost or FVOCI and as a result marketable securi-ties are measured at FVPL. This classification is consistent with the prior year's classification. Genmab invests its cash in deposits with major financial institutions, in AAA rated money market funds, Danish mortgage bonds, investment grade rated corporate debt, commercial paper, certifi-cates of deposit, certain types of AAA rated asset backed securities, U.S. Agency bonds, and notes issued by the Danish, European and U.S. govern-ments. The securities can be purchased and sold using established markets. Transactions are recognized at the trade date. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag100.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;100 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 4 Capital Structure, Financial Risk and Related Items \| 4.5 Financial Income and Expenses 4.5 Financial Income and Expenses (DKK million) 2022 2021 2020 Financial income: Interest and other financial income 324 197 184 Gain on other investments, net – – 965 Foreign exchange rate gain, net 1,034 1,470 – Total financial income 1,358 1,667 1,149 Financial expenses: Interest and other financial expenses (21) (13) (10) Loss on marketable securities, net (361) (246) (92) Loss on other investments, net (298) (443) – Foreign exchange rate loss, net – – (1456) Total financial expenses (680) (702) (1558) Net financial items 678 965 (409) Interest Income Interest income was DKK 324 million in 2022 compared to DKK 197 million in 2021. The increase of DKK 127 million, or 64%, was driven by higher effective interest rates in the U.S., Europe and Denmark for the respective periods. Foreign Exchange Rate Gains and Losses Foreign exchange rate gains of DKK 1,034 million in 2022 and DKK 1,470 million in 2021, and losses of DKK 1,456 million in 2020 were primarily driven by foreign exchange movements impacting Genmab's USD denominated marketable securities and cash and cash equivalents; in particular, the USD/DKK foreign exchange rates were as follows for each period: December 31, 2022 December 31, 2021 December 31, 2020 USD/DKK Foreign Exchange Rates 6.9722 6.5612 6.0524 % Increase/(Decrease) 6% 8% (9)% Refer to Note 4.2 for additional information on foreign currency risk. Marketable Securities Gains and Losses Loss on marketable securities, net was DKK 361 million in 2022 and DKK 246 million in 2021. The increase in losses of DKK 115 million, or 47%, was primarily driven by higher interest rates on Genmab's Danish mortgage investments in 2022 as compared to 2021. Loss on marketable securities, net was DKK 246 million in 2021 and DKK 92 million in 2020. The increase in losses of DKK 154 million was primarily driven by the movements in interest rates in the U.S. and Europe in the respective periods. Other Investments Loss on other investments, net was DKK 298 million in 2022 and DKK 443 million in 2021, and gain on other investments, net was DKK 965 million in 2020. The losses and gains in the respective periods are primarily driven by the change in fair value of Genmab's investment in common shares of CureVac. Accounting Policies Financial income and expenses include interest as well as foreign exchange rate adjustments and gains and losses on marketable securities (designated as FVPL) and realized gains and losses and write-downs of other securities and equity interests (designated as available-for-sale financial assets). Interest income is shown separately from gains and losses on marketable securities and other securities and equity interests. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag101.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;101 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 4 Capital Structure, Financial Risk and Related Items \| 4.6 Share-Based Instruments 4.6 Share-Based Instruments Restricted Stock Unit Program Genmab A/S has established an RSU program (equity-settled share-based payment transac-tions) as an incentive for Genmab's employees, members of the Executive Management, and members of the Board of Directors. RSUs granted to Executive Management are performance-based. RSUs are granted by the Board of Directors. RSU grants to members of the Board of Directors and members of the Executive Management are subject to the Remuneration Policy adopted at the Annual General Meeting. See the table below for a summary of key terms of Genmab's RSU programs: RSUs Granted in Periods Key Terms December 2019–February 2021 From February 2021 Grants Granted at closing share price on the grant date. Vesting (Settlement) Cliff vesting—RSUs become fully vested on the first banking day of the month following a period of 3 years from the grant date. After RSUs vest, the holder receives one share in Genmab A/S for each RSU granted. In jurisdictions in which Genmab as an employer is required to withhold tax and settle with the tax authority on behalf of the employee, Genmab withholds the number of RSUs that are equal to the monetary value of the employee's tax obligation from the total number of RSUs that otherwise would have been issued to the employee upon vesting ("net settlement"). Genmab A/S may at its sole discretion in extraordinary circumstances choose to make a cash settlement instead of delivering shares. Leaver Leavers—Forfeit all unvested RSUs except when due to retirement, death, serious sickness or serious injury, in which case granted but not yet vested RSUs shall remain outstanding and will be settled in accordance with their terms. Notwithstanding the above, the December 2020 RSU grant to members of the Board of Directors was made subject to pro-rata vesting upon termination of board services. Employees and Executive Management— RSUs remain outstanding and vest accordingly when the employment relationship is terminated by Genmab without cause. Good-Leavers1—May maintain a pro-rata portion of unvested RSUs Bad-Leavers2—Forfeit all unvested RSUs. Death—Forfeit all unvested RSUs. 1."Good-Leaver"—Dismissal without cause or termination of employment due to the Genmab's material breach of the RSU or Warrant holder's employment terms, or if the participant is a member of the Board of Directors, if the membership of the Board of Directors ceases for any other reason than as a result of the participants death. 2."Bad-leaver"—Dismissed for cause or during the employment probationary period. The RSU program contains anti-dilution provisions if changes occur in Genmab's share capital prior to the vesting date and provisions to accelerate vesting of RSUs in the event of change of control as defined in the RSU program. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag102.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;102 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 4 Capital Structure, Financial Risk and Related Items \| 4.6 Share-Based Instruments RSU Activity in 2022, 2021 and 2020 Number of RSUs held by the Board of Directors Number of RSUs held by the Executive Management Number of RSUs held by employees Number of RSUs held by former members of the Executive Management, Board of Directors and employees Total RSUs Weighted Average Fair Value—RSUs Granted—DKK Outstanding at January 1, 2020 19,953 72,865 208,859 6,230 307,907 Granted\* 2,929 9,032 34,431 130 46,522 1,927.83 Settled (6470) (12253) (22196) (5936) (46855) Transferred (2822) (2334) (22762) 27,918 – Cancelled (1025) (1128) (958) (10535) (13646) Outstanding at December 31, 2020 12,565 66,182 197,374 17,807 293,928 Outstanding at January 1, 2021 12,565 66,182 197,374 17,807 293,928 Granted\* 3,297 31,417 146,684 4,817 186,215 2,236.44 Settled (3556) (14089) (35962) (9967) (63574) Transferred (688) 5,533 (14810) 9,965 – Cancelled (653) – (255) (9670) (10578) Outstanding at December 31, 2021 10,965 89,043 293,031 12,952 405,991 Outstanding at January 1, 2022 10,965 89,043 293,031 12,952 405,991 Granted\* 4,295 40,453 221,000 6,383 272,131 2,250.18 Settled (3420) (17165) (67945) (12847) (101377) Transferred (2368) – (13749) 16,117 – Cancelled (653) – (9195) (18759) (28607) Outstanding at December 31, 2022 8,819 112,331 423,142 3,846 548,138 \*RSUs held by the Board of Directors include RSUs granted to employee-elected Board Members as employees of Genmab A/S or its subsidiaries. Refer to Note 5.1 for additional information regarding compensation of Executive Management and the Board of Directors. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag103.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;103 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 4 Capital Structure, Financial Risk and Related Items \| 4.6 Share-Based Instruments Warrant Program Genmab A/S has established a warrant program (equity-settled share-based payment trans-actions) as an incentive for all the Genmab Group's employees and members of the Executive Management. Warrants are granted by the Board of Directors in accordance with authorizations given to it by Genmab A/S' shareholders. Warrant grants to Executive Management are subject to Genmab's Remuneration Policy adopted at the Annual General Meeting. See the table below for a summary of key terms of Genmab's warrant programs: Warrants Granted in Periods Key Terms April 2012–March 2017 March 2017–February 2021 From February 2021 Grants Granted at an exercise price equal to the closing share price on the grant date. Vesting (Exercisable) Annually over 4-year period (25% per year) Cliff vesting over 3-year period (100% after 3 years) Leaver Leavers—Forfeit all unvested warrants; however, may be able to exercise warrants on a regular schedule in instances where the employment relationship is terminated by Genmab without cause. Good-Leavers—May maintain a pro-rata portion of unvested warrants Bad-Leavers—Forfeit all unvested warrants. Death—Forfeit all unvested warrants. Lapse 7th anniversary of grant date The warrant program contains anti-dilution provisions if changes occur in Genmab's share capital prior to the warrants being exercised and provisions to accelerate vesting of warrants in the event of change of control or certain other extraordinary transactions as defined in the warrant program. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag104.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;104 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 4 Capital Structure, Financial Risk and Related Items \| 4.6 Share-Based Instruments Warrant Activity in 2022, 2021 and 2020 Number of warrants held by the Board of Directors Number of warrants held by the Executive Management Number of warrants held by employees Number of warrants held by former members of the Executive Management, Board of Directors and employees Total warrants Weighted average exercise price—DKK Weighted average share price at exercise date—DKK Outstanding Warrants— % of Share Capital Outstanding at January 1, 2020 62,334 347,801 858,973 144,516 1,413,624 862.03 Granted\* – 7,771 110,041 416 118,228 2,009.79 Exercised (24438) – (122015) (324793) (471246) 296.77 2,035.29 Expired – – – – – – Cancelled – (28424) (589) (43125) (72138) 1,157.54 Transfers (25955) (186333) (113833) 326,121 – – Outstanding at December 31, 2020 11,941 140,815 732,577 103,135 988,468 1,247.22 2% Exercisable at year end 4,192 83,426 166,402 92,696 346,716 935.60 Exercisable warrants in the money at year end 4,192 83,426 166,402 92,696 346,716 935.60 Outstanding at January 1, 2021 11,941 140,815 732,577 103,135 988,468 1,247.22 Granted\* 1,217 1,287 167,080 6,400 175,984 2,282.35 Exercised (2500) (7250) (105726) (57232) (172708) 780.48 2,439.80 Expired – – – – – – Cancelled – – (477) (22816) (23293) 1,956.91 Transfers – 24,782 (54454) 29,672 – – Outstanding at December 31, 2021 10,658 159,634 739,000 59,159 968,451 1,501.49 1% Exercisable at year end 6,594 135,723 219,386 50,021 411,724 1,058.41 Exercisable warrants in the money at year end 6,594 135,723 219,386 50,021 411,724 1,058.41 Outstanding at January 1, 2022 10,658 159,634 739,000 59,159 968,451 1,501.49 Granted\* 1,541 – 250,005 7,412 258,958 2,244.22 Exercised (1558) (29836) (176948) (34775) (243117) 1,154.95 2,815.33 Expired – – – – – – Cancelled – – (13670) (32654) (46324) 2,029.00 Transfers (8721) – (25373) 34,094 – – Outstanding at December 31, 2022 1,920 129,798 773,014 33,236 937,968 1,770.31 1% Exercisable at year end 617 118,571 282,296 32,695 434,179 1,265.68 Exercisable warrants in the money at year end 617 118,571 282,296 32,695 434,179 1,265.68 \*Warrants held by the Board of Directors include warrants granted to employee-elected Board Members as employees of Genmab A/S or its subsidiaries. Refer to Note 5.1 for additional information regarding compensation of Executive Management and the Board of Directors. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag105.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;105 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 4 Capital Structure, Financial Risk and Related Items \| 4.6 Share-Based Instruments Weighted Average Outstanding Warrants at December 31, 2022 Exercise price DKK Grant Date Number of warrants outstanding Weighted average remaining contractual life (in years) Number of warrants exercisable 815.50 March 17, 2016 2,725 0.21 2,725 962.00 June 7, 2018 4,646 2.44 4,646 1,025.00 December 10, 2018 109,918 2.94 109,918 1,032.00 December 15, 2017 63,230 1.96 63,230 1,050.00 September 21, 2018 14,024 2.73 14,024 1,136.00 October 6, 2016 2,695 0.77 2,695 1,145.00 December 15, 2016 14,963 0.96 14,963 1,147.50 June 6, 2019 9,386 3.43 9,386 1,155.00 March 29, 2019 5,509 3.25 5,509 1,161.00 March 1, 2019 10,128 3.17 10,128 1,210.00 April 10, 2018 7,090 2.28 7,090 1,233.00 June 9, 2016 3,681 0.44 3,681 1,334.50 October 11, 2019 32,150 3.78 32,150 1,362.50 March 26, 2020 30,938 4.24 – 1,402.00 March 28, 2017 6,837 1.24 6,837 1,408.00 June 8, 2017 954 1.44 954 1,424.00 February 10, 2017 408 1.11 408 1,427.00 March 29, 2017 8,400 1.25 8,400 1,432.00 October 5, 2017 1,994 1.76 1,994 1,615.00 December 5, 2019 135,441 3.93 135,441 1,948.00 June 3, 2020 12,961 4.43 – 2,070.00 February 26, 2021 90,968 5.16 – 2,103.00 June 9, 2022 22,221 6.44 – 2,129.00 January 25, 2022 15,986 6.07 – 2,148.00 April 13, 2021 15,097 5.29 – 2,175.00 February 25, 2022 166,286 6.15 – 2,317.00 October 7, 2020 34,109 4.77 – 2,381.00 December 15, 2020 22,983 4.96 – 2,408.00 March 29, 2022 13,459 6.25 – 2,492.00 January 28, 2021 10,053 5.08 – 2,585.00 September 20, 2022 19,644 6.72 – 2,641.00 November 22, 2021 6,456 5.89 – 2,698.00 June 22, 2021 14,216 5.48 – 2,806.00 October 7, 2021 19,476 5.77 – 3,172.00 November 21, 2022 8,936 6.89 – 1,770.31 937,968 4.40 434,179 Weighted Average Outstanding Warrants at December 31, 2021 Exercise price DKK Grant Date Number of warrants outstanding Weighted average remaining contractual life (in years) Number of warrants exercisable 466.20 March 26, 2015 600 0.24 600 623.50 June 11, 2015 650 0.45 650 636.50 October 7, 2015 7,700 0.77 7,700 815.50 March 17, 2016 5,301 1.21 5,301 939.50 December 10, 2015 20,612 0.94 20,612 962.00 June 7, 2018 6,527 3.44 6,527 1,025.00 December 10, 2018 169,565 3.94 169,565 1,032.00 December 15, 2017 79,771 2.96 79,771 1,050.00 September 21, 2018 16,806 3.73 16,806 1,136.00 October 6, 2016 10,424 1.77 10,424 1,145.00 December 15, 2016 53,374 1.96 53,374 1,147.50 June 6, 2019 17,209 4.43 – 1,155.00 March 29, 2019 7,662 4.25 – 1,161.00 March 1, 2019 19,028 4.17 – 1,210.00 April 10, 2018 10,189 3.28 10,189 1,233.00 June 9, 2016 9,030 1.44 9,030 1,334.50 October 11, 2019 52,223 4.78 – 1,362.50 March 26, 2020 32,054 5.24 – 1,402.00 March 28, 2017 7,110 2.24 7,110 1,408.00 June 8, 2017 1,274 2.44 1,274 1,424.00 February 10, 2017 946 2.11 946 1,427.00 March 29, 2017 8,400 2.25 8,400 1,432.00 October 5, 2017 3,445 2.76 3,445 1,615.00 December 5, 2019 183,240 4.93 – 1,948.00 June 3, 2020 14,898 5.43 – 2,070.00 February 26, 2021 96,840 6.16 – 2,148.00 April 13, 2021 16,880 6.29 – 2,317.00 October 7, 2020 36,949 5.77 – 2,381.00 December 15, 2020 23,761 5.96 – 2,492.00 January 28, 2021 12,329 6.08 – 2,641.00 November 22, 2021 6,879 6.89 – 2,698.00 June 22, 2021 15,261 6.48 – 2,806.00 October 7, 2021 21,514 6.77 – 1,501.49 968,451 4.39 411,724 |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag106.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;106 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 4 Capital Structure, Financial Risk and Related Items \| 4.6 Share-Based Instruments Accounting Policies Share-Based Compensation Expenses Share-based compensation expense is recog-nized in the income statement based on the estimated fair value of the awards at grant date. Subsequently, the fair value is not remeasured. The expense recognized reflects an estimate of the number of awards expected to vest after taking into consideration an estimate of award forfeitures based on historical experience and is recognized on a straight-line basis over the requisite service period, which is the vesting period. Genmab reassesses its estimate of the number of shares expected to vest periodically. Management expectations related to the achievement of performance goals associated with performance based RSU grants is assessed periodically, and that assessment is used to determine whether such grants are expected to vest or if any revision to the current estimate is required. Genmab recognizes the impact of the revised estimate of the number of awards expected to vest, if any, as an adjustment to the income statement over the remaining vesting period. If performance-based milestones related to performance-based RSU grants are not met or not expected to be met, any share-based compen-sation expense recognized to date associated with grants that are not expected to vest will be reversed. Share-based compensation expenses represent calculated values of warrants, RSUs and performance-based RSUs granted and do not represent actual cash expenditures. A corre-sponding amount is recognized in shareholders' equity as the warrant, RSU and performance-based RSU programs are designated as equity-settled share-based payment transactions. Management's Judgements and Estimates Share-Based Compensation Expenses The fair value of each warrant granted during the year is calculated using the Black-Scholes pricing model. This pricing model requires the input of subjective assumptions such as: • The expected stock price volatility, which is based upon the historical volatility of Genmab's stock price; • The risk-free interest rate, which is determined as the interest rate on Danish government bonds (bullet issues) with a maturity of five years; • The expected life of warrants, which is based on vesting terms, expected rate of exercise and life terms in the current warrant program. These assumptions can vary over time and can change the fair value of future warrants granted. Valuation Assumptions for Warrants Granted in 2022, 2021 and 2020 The fair value of each warrant granted during the year is calculated using the Black-Scholes pricing model with the following assumptions: 2022 2021 2020 Weighted average Fair value per warrant on grant date 664.08 701.82 631.51 Share price 2,244.22 2,282.35 2,009.79 Exercise price 2,244.22 2,282.35 2,009.79 Expected dividend yield 0% 0% 0% Expected stock price volatility 33.5% 36.6% 37.0% Risk-free interest rate 0.15% -0.54% -0.58% Expected life of warrants 5 years 5 years 5 years Total Fair Value of Amounts Granted Total fair value of warrants granted DKK 172 million DKK 124 million DKK 75 million Total fair value of RSUs granted DKK 612 million DKK 416 million DKK 90 million |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag107.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;107 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 4 Capital Structure, Financial Risk and Related Items \| 4.7 Share Capital 4.7 Share Capital Share Capital The share capital comprises the nominal amount of Genmab A/S ordinary shares, each at a nominal value of DKK 1. All shares are fully paid. As of December 31, 2022, the share capital of Genmab A/S comprised 65,961,573 shares of DKK 1 each with one vote. There are no restric-tions related to the transferability of the shares. All shares are regarded as negotiable instruments and do not confer any special rights upon the holder, and no shareholder shall be under an obli-gation to allow his/her shares to be redeemed. Genmab's Board of Directors is authorized to increase the share capital by subscription of new shares, issue warrants to subscribe for shares and raise loans against bonds as well as other financial instruments of Genmab A/S as set out in articles 4A-5B of Genmab A/S' Articles of Association. Further, Genmab's share capital is in compliance with the capital requirements of the Danish Companies Act and the rules of Nasdaq Copenhagen. See table below for warrants issued and reissued and warrants available for reissue under active authorizations as of December 31, 2022: April 13, 2021 Authorization March 29, 2019 Authorization March 28, 2017 Authorization Warrants issued 68,291 500,000 500,000 Warrants reissued 1,333 59,671 63,558 Warrants available for issue 681,709 – – Warrants available for reissue 1,254 10,661 – Share Premium The share premium reserve is comprised of the amount received, attributable to shareholders' equity, in excess of the nominal amount of the shares issued at the parent company's offerings, reduced by any external expenses directly attributable to the offerings. The share premium reserve can be distributed. Changes in Share Capital During 2020 to 2022 The share capital of DKK 66 million at December 31, 2022 is divided into 65,961,573 shares at a nominal value of DKK 1 each. Number of shares Share capital (DKK million) Share Price Ranges1 December 31, 2019 65,074,502 65.1 Exercise of warrants 471,246 0.4 DKK 31.75 to DKK 1,432.00 December 31, 2020 65,545,748 65.5 Exercise of warrants 172,708 0.2 DKK 31.75 to DKK 1,432.00 December 31, 2021 65,718,456 65.7 Exercise of warrants 243,117 0.3 DKK 466.20 to DKK 1,615.00 December 31, 2022 65,961,573 66.0 1.New shares were subscribed at share prices in connection with the exercise of warrants under Genmab's warrant program. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag108.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;108 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 4 Capital Structure, Financial Risk and Related Items \| 4.7 Share Capital Treasury Shares Number of shares Share capital (DKK million) Proportion of share capital % Cost (DKK million) Shareholding at December 31, 2019 163,921 0.2 0.3 192 Shares used for funding RSU program (31815) (0.1) (0.1) (38) Shareholding at December 31, 2020 132,106 0.1 0.2 154 Purchase of treasury shares 200,000 0.2 0.3 447 Shares used for funding RSU program (43781) – (0.1) (51) Shareholding at December 31, 2021 288,325 0.3 0.4 550 Purchase of treasury shares 370,000 0.4 0.6 908 Shares used for funding RSU program (68377) (0.1) (0.1) (80) Shareholding at December 31, 2022 589,948 0.6 0.9 1,378 Share Repurchases Genmab intends to purchase its own shares primarily to cover obligations in relation to the share-based remuneration programs and reduce the dilution effect of share capital increases resulting from future exercises of warrants. 2021 Authorization 2019 Authorization 2016 Authorization Number of shares authorized for repurchase1 500,000 500,000 500,000 Actual shares repurchased under authorization 40,000 500,000 255,000 Shares available for repurchase as of December 31, 2022 460,000 – – 1.Nominal value of DKK 500,000 As announced on June 17, 2022, Genmab initiated a share buy-back program. During 2022, Genmab acquired 370,000 of its own shares, representing approximately 0.6% of share capital as of December 31, 2021. The total amount paid to acquire the shares, including directly attributable costs, was DKK 908 million and was recognized as a deduction to shareholders' equity. During 2021, Genmab acquired 200,000 of its own shares, representing approximately 0.3% of share capital as of December 31, 2020. The total amount paid to acquire the shares, including directly attributable costs, was DKK 447 million and was recognized as a deduction to shareholders' equity. These shares are classi-fied as treasury shares and are presented within retained earnings on the balance sheet as of December 31, 2022. As of December 31, 2022, 589,948 treasury shares were held by Genmab. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag109.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;109 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group 5.1 Remuneration of the Board of Directors and Executive Management The total remuneration of the Board of Directors and Executive Management is as follows: (DKK million) 2022 2021 2020 Wages and salaries 55 51 48 Share-based compensation expenses 70 58 43 Defined contribution plans 2 2 2 Total 127 111 93 The remuneration packages for the Board of Directors and Executive Management are described in further detail in Genmab's 2022 Compensation Report. The remuneration packages are denominated in DKK, EUR, or USD. The Compensation Committee of the Board of Directors performs an annual review of the remu-neration packages. All incentive and variable remuneration is considered and adopted at the Company's Annual General Meeting. Share-based compensation is included in the income statement and reported in the table above. Share-based compensation expense represents the estimated fair value of the awards at grant date and does not represent actual cash compensation received by the Board Members or Executive Management. Refer to Note 4.6 for additional information regarding Genmab's share-based compensation programs and accounting policies. Other Disclosures This section is comprised of various statutory disclosures or notes that are of secondary importance for the understanding of Genmab's financials. Section 5 |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag110.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;110 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 5 Other Disclosures \| 5.1 Remuneration of the Board of Directors and Executive Management Remuneration to the Board of Directors Base Board Fee Committee Fees Share-Based Compensation Expenses Total (DKK million) 2022 2021 2020 2022 2021 2020 2022 2021 2020 2022 2021 2020 Deirdre P. Connelly 1.2 1.2 1.1 0.5 0.5 0.5 0.9 0.7 0.7 2.6 2.4 2.3 Pernille Erenbjerg 0.9 0.9 0.7 0.4 0.4 0.4 0.7 0.5 0.4 2.0 1.8 1.5 Anders Gersel Pedersen 0.6 0.6 0.4 0.4 0.4 0.4 0.5 0.4 0.5 1.5 1.4 1.3 Paolo Paoletti 0.6 0.6 0.4 0.3 0.3 0.3 0.5 0.4 0.4 1.4 1.3 1.1 Rolf Hoffmann 0.6 0.6 0.4 0.3 0.4 0.3 0.5 0.4 0.5 1.4 1.4 1.2 Elizabeth O'Farrell1 0.5 – – 0.2 – – 0.6 – – 1.3 – – Jonathan Peacock2 – 0.5 0.3 – 0.3 0.3 – 0.6 0.4 – 1.4 1.0 Mats Pettersson3 – – 0.3 – – 0.1 – – 1.6 – – 2.0 Mijke Zachariasse4 0.6 0.6 0.4 – – – 0.4 0.3 0.1 1.0 0.9 0.5 Martin Schultz4 0.5 – – – – – – – – 0.5 – – Takahiro Hamatani4 0.5 – – – – – – – – 0.5 – – Peter Storm Kristensen5 0.1 0.6 0.4 – – – 0.1 0.4 0.4 0.2 1.0 0.8 Rima Bawarshi Nassar5,6 0.1 0.6 0.1 – – – 0.1 0.2 – 0.2 0.8 0.1 Daniel J. Bruno6 – – 0.3 – – – – – (0.4) – – (0.1) Total 6.2 6.2 4.8 2.1 2.3 2.3 4.3 3.9 4.6 12.6 12.4 11.7 1. Elizabeth O'Farrell was newly elected to the Board of Directors at the Annual General Meeting in March 2022. 2. Jonathan Peacock stepped down from the Board of Directors effective November 15, 2021, due to increased responsibilities in connection with his other board commitments. 3. Mats Pettersson stepped down from the Board of Directors at the Annual General Meeting in March 2020. 4. Employee elected board members were elected at the Annual General Meeting in March 2022. 5. Peter Storm Kristensen and Rima Bawarshi Nassar stepped down from the Board of Directors as employee elected board members at the Annual General Meeting in March 2022. 6.Daniel J. Bruno stepped down from the Board of Directors and Rima Bawarshi Nassar replaced Daniel J. Bruno on the Board of Directors as an employee elected board member during August 2020. Refer to the section "Board of Directors" in Management's Review for additional information regarding the Board of Directors. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag111.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;111 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 5 Other Disclosures \| 5.1 Remuneration of the Board of Directors and Executive Management Remuneration to the Executive Management Base Salary Defined Contribution Plans Other Benefits Annual Cash Bonus Share-Based Compensation Expenses Total (DKK million) 2022 2021 2020 2022 2021 2020 2022 2021 2020 2022 2021 2020 2022 2021 2020 2022 2021 2020 Jan van de Winkel 8.6 7.9 7.3 1.3 1.1 1.0 0.3 0.6 1.0 8.6 7.9 8.4 22.9 20.6 19.6 41.7 38.1 37.3 Anthony Pagano1 4.3 3.2 3.0 0.1 0.1 0.1 – – – 2.6 1.9 2.3 9.5 7.2 5.2 16.5 12.4 10.6 Anthony Mancini2 4.7 3.9 3.1 0.1 0.1 0.1 – 3.1 3.3 2.8 2.3 2.0 11.4 7.2 3.1 19.0 16.6 11.6 Judith Klimovsky 4.9 4.0 4.0 0.1 0.1 0.1 – – 0.1 2.9 2.5 3.0 14.1 13.2 12.7 22.0 19.8 19.9 Tahamtan Ahmadi3 4.6 3.3 – 0.1 0.1 – – – – 2.8 2.0 – 7.7 5.5 – 15.2 10.9 – David A. Eatwell1 – – 0.9 – – 0.1 – – 2.5 – – – – – (2.3) – – 1.2 Total 27.1 22.3 18.3 1.7 1.5 1.4 0.3 3.7 6.9 19.7 16.6 15.7 65.6 53.7 38.3 114.4 97.8 80.6 1. David A. Eatwell stepped down as CFO on February 29, 2020, and Anthony Pagano was appointed CFO and member of the Executive Management on March 1, 2020. 2. Anthony Mancini was appointed Chief Operating Officer and member of the Executive Management in March 2020. 3. Tahamtan Ahmadi was appointed Chief Medical Officer, Head of Experimental Medicines and member of the Executive Management in March 2021. Genmab has decided to implement an adminis-trative organizational change whereby effective January 1, 2023, only Jan van de Winkel, President and Chief Executive Officer, and Anthony Pagano, Executive Vice President and Chief Financial Officer, will be formally registered as executive managers with the Danish Business Authority. Judith Klimovsky, Executive Vice President and Chief Development Officer, Anthony Mancini, Executive Vice President and Chief Operating Officer, and Tahamtan Ahmadi, Executive Vice President and Chief Medical Officer, will cease to be registered as executive managers with the Danish Business Authority; however, apart from the formal registration amendments there will be no changes to the Executive Management Team, including titles, areas of responsibility or otherwise. Refer to the section "Senior Leadership" in Management's Review for additional informa-tion regarding the Executive Management. Severance Payments: In the event Genmab terminates the service agreements with any member of the Executive Management team without cause, Genmab is obliged to pay his/her existing salary for one or two years after the end of the one-year notice period. However, in the event of termination by Genmab (unless for cause) or by any member of Executive Management as a result of a change of control of Genmab, Genmab is obliged to pay compensation equal to his/her existing total salary (including benefits) for up to two years in addition to the notice period. In 2021, the Remuneration Policy was amended at the Annual General Meeting to specify that the total value of the remuneration relating to the notice period for new members of Executive Management cannot exceed two years of remuneration, including all components of the remuneration. In case of the termination of the service agreements of the Executive Management without cause, the total impact on our financial position is estimated to be approximately DKK 82 million as of December 31, 2022 (2021: DKK 72 million, 2020: DKK 52 million). |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag112.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;112 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 5 Other Disclosures \| 5.2 Related Party Disclosures 5.2 Related Party Disclosures Genmab's related parties are the parent company's subsidiaries, Board of Directors, Executive Management, and close members of the family of these persons. Genmab has not granted any loans, guarantees or other commitments to or on behalf of any of the members of the Board of Directors or Executive Management. Other than the remuneration and other trans-actions relating to the Board of Directors and Executive Management described in Note 5.1, there were no material related party transactions during 2022, 2021 and 2020. 5.3 Commitments Purchase Obligations Genmab has entered into a number of agreements related to research and development activities that contain various obligations. These short-term contractual obligations amounted to approxi-mately DKK 1,687 million as of December 31, 2022, all of which is due in less than two years (2021: approximately DKK 1,340 million). Genmab also has certain contingent commitments under license and collaboration agreements that may become due in the future. As of December 31, 2022, these contingent commitments amounted to approximately DKK 20,077 million (USD 2,880 million) in potential future development, regu-latory and commercial milestone payments to third parties under license and collaboration agreements for our pre-clinical and clinical stage development programs as compared to approxi-mately DKK 19,574 million (USD 2,983 million) as of December 31, 2021. These milestone payments generally become due and payable only upon the achievement of certain development, clinical, regulatory or commercial milestones. The events triggering such payments or obligations have not yet occurred. In addition to the above obligations, Genmab enters into a variety of agreements and financial commitments in the normal course of business. The terms generally allow Genmab the option to cancel, reschedule and adjust our require-ments based on our business needs prior to the delivery of goods or performance of services. It is not possible to predict the maximum potential amount of future payments under these agree-ments due to the conditional nature of our obligations and the unique facts and circum-stances involved in each particular agreement. 5.4 Fees to Auditors Appointed at the Annual General Meeting (DKK million) 2022 2021 2020 PricewaterhouseCoopers Audit fees 5.8 5.8 4.9 Audit-related fees 2.0 1.8 1.0 Tax fees – – 0.3 All other fees – 0.1 – Total 7.8 7.7 6.2 Fees for other services than statutory audit of the financial statements provided by PricewaterhouseCoopers Statsautoriseret Revisionspartnerselskab amounted to DKK 2.0 million in 2022 (DKK 1.9 million and DKK 1.3 million in 2021 and 2020, respectively). These services primarily include agreed-upon procedures, other assurance assessments and reports, accounting advice, educational training and tax and VAT compliance. 5.5 Adjustments to Cash Flow Statements (DKK million) Note 2022 2021 2020 Adjustments for non-cash transactions: Depreciation, amortization and impairment 3.1, 3.2, 3.3 362 248 259 Share-based compensation expenses 2.3, 4.6 439 310 200 Other – (32) – Total adjustments for non-cash transactions 801 526 459 Change in operating assets and liabilities: Receivables (2213) (1074) 306 Deferred revenue – – 513 Other payables 283 304 168 Total change in operating assets and liabilities (1930) (770) 987 |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag113.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;113 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 5 Other Disclosures \| 5.6 Collaborations and Technology Licenses 5.6 Collaborations and Technology Licenses Collaborations Genmab enters into collaborations with biotech-nology and pharmaceutical companies to advance the development and commercialization of Genmab's product candidates and to supplement its internal pipeline. Genmab seeks collabora-tions that will allow Genmab to retain significant future participation in product sales through either profit-sharing or royalties paid on net sales. Below is an overview of certain of Genmab's collaborations that have had, or are expected in the near term to have, a significant impact on financial results. Janssen (Daratumumab/DARZALEX) In 2012, Genmab entered into a global license, development and commercialization agreement with Janssen for daratumumab (marketed for the treatment of certain multiple myeloma indica-tions as DARZALEX for IV administration and as DARZALEX FASPRO in the U.S. and DARZALEX SC in Europe for SC administration). Under this agreement, Janssen is fully responsible for devel-oping and commercializing daratumumab, and all costs associated therewith. Genmab receives tiered royalty payments between 12% and 20% based on Janssen's annual net product sales. The royalties payable by Janssen are limited in time and subject to reduction on a country-by-country basis for customary reduction events, including upon patent expiration or invalidation in the relevant country and upon the first commercial sale of a biosimilar product in the relevant country (for as long as the biosimilar product remains for sale in that country). Pursuant to the terms of the agreement, Janssen's obligation to pay royalties under this agreement will expire on a country-by-country basis on the later of the date that is 13 years after the first commercial sale of dara-tumumab in such country or upon the expiration of the last-to-expire relevant Genmab-owned patent (as defined in the agreement) covering daratumumab in such country. Genmab is also eligible to receive certain additional payments in connection with development, regulatory and sales milestones. In September 2020, Genmab commenced binding arbitration of two matters arising under its license agreement with Janssen relating to daratumumab. Under the license agreement, Genmab is, among other things, entitled to royalties from Janssen on net sales of daratumumab (marketed as DARZALEX for IV administration and as DARZALEX FASPRO in the U.S. and as DARZALEX SC in Europe for SC administration). In April 2022, the arbitral tribunal issued an award in the binding arbitration of the two matters. Genmab did not seek a review of the award, and the award is now final. The first matter concerned the question as to whether Janssen's obligation to pay royalties on sales of licensed product extends, in each applicable country, until the expiration or invalidation of the last-to-expire relevant Genmab-owned patent or the last-to-expire relevant Janssen-owned patent covering the product, as further defined and described in the license agreement. As to that matter, the tribunal determined by majority opinion that Janssen's obligation to pay royalties to Genmab on sales of licensed product, in each applicable country, extends through the expiration or invalidation of the last-to-expire relevant Genmab-owned patent covering the product or use thereof, but not the relevant Janssen-owned patent. The relevant Genmab-owned issued U.S., European and Japanese patents will expire in the late 2020s and early 2030s. The second matter concerned the question as to whether Genmab is required to share in Janssen's royalty payments to Halozyme for the Halozyme enzyme technology used in the SC formulation of daratumumab (marketed as DARZALEX FASPRO in the U.S.). The royalties Janssen pays to Halozyme represent a mid-single digit percentage rate of SC daratumumab sales. As to that matter, the tribunal ruled by majority opinion that Janssen is permitted to continue reducing its royalty payments to Genmab as an offset against a share of Janssen's royalty payments made to Halozyme. On June 9, 2022, Genmab announced the commencement of a second arbitration under the daratumumab license agreement with Janssen. This second arbitration follows from the award in the prior arbitration, where the tribunal ruled in favor of Janssen on the question as to whether Genmab is required to share in Janssen's royalty payments to Halozyme for its technology used in the daratumumab SC product. The tribunal based its ruling on the finding that DARZALEX FASPRO constitutes a new licensed product under the license agreement. In this second arbitration, Genmab is conse-quently seeking an award of USD 405 million plus interest in accrued milestone payments for DARZALEX FASPRO and a declaration that it is entitled to a new 13-year royalty term from the date of DARZALEX FASPRO's first commercial sale. See Company Announcement no. 21/2022. Novartis (Ofatumumab/Kesimpta) Genmab and GlaxoSmithKline (GSK) entered a co-development and collaboration agreement for ofatumumab in 2006. The full rights to ofatu-mumab were transferred from GSK to Novartis in 2015. Novartis is now fully responsible for the development and commercialization of ofatu-mumab in all potential indications, including autoimmune diseases. Genmab is entitled to a 10% royalty payment of net sales for non-cancer treatments. Novartis's obligation to pay royalties under this agreement expire on a country-by-country basis only in the event Novartis is no longer selling such product is a given country. In 2020 SC ofatumumab was approved by the U.S. FDA, as Kesimpta, for the treatment of RMS in adults. Ofatumumab was also previously approved as Arzerra® for certain CLL indications. In 2019, the marketing authorization for Arzerra was withdrawn in the EU and several other territories. In August 2020, Genmab announced that Novartis planned to transition Arzerra to an oncology  |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag115.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;115 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Group Section 5 Other Disclosures \| 5.7 Subsequent Events including, but not limited to, discount rate, devel-opment timeline, regulatory risks, estimated market demand and future revenue potential. For co-development activities related to up to four product concepts, a cost-plus margin approach was utilized. The performance obligations related to the delivery of licenses were completed at a point in time (June 2020) and Genmab recognized USD 672 million (DKK 4,398 million) as license fee revenue in June 2020. After delivery of the licenses, Genmab shares further development and commercial costs equally with AbbVie. AbbVie is not assessed as a customer but as a collaboration partner, and as such this part of the collaboration is not in scope of IFRS 15. In September 2021, Genmab, along with AbbVie, decided that the data did not support the further development of DuoBody-CD3x5T4. In June 2022, AbbVie decided to discontinue co-development of DuoHexaBody-CD37. Upon expiry of the 180-day notice period on December 24, 2022, Genmab became solely responsible for the further devel-opment of DuoHexaBody-CD37 against low-single digit royalty payments to AbbVie, up to an agreed maximum total royalty amount, based on future potential sales of the product. Refer to Note 3.6 for information pertaining to the remaining performance obligation related to co-development activities for the product concepts. BioNTech In May 2015, Genmab entered into an agreement with BioNTech to jointly research, develop and commercialize bispecific antibody products using Genmab's DuoBody technology platform. Under the terms of the agreement, BioNTech will provide proprietary antibodies against key immunomodu-latory targets, while Genmab provides proprietary antibodies and access to its DuoBody technology platform. Genmab paid an upfront fee of USD 10 million to BioNTech and an additional fee as certain BioNTech assets were selected for further development. If the companies jointly select any product candidates for clinical development, development costs and product ownership will be shared equally going forward. If one of the companies does not wish to move a product candidate forward, the other company is entitled to continue developing the product on prede-termined licensing terms. The agreement also includes provisions which will allow the parties to opt out of joint development at key points. During July 2022, Genmab and BioNTech expanded this collaboration to include the joint research, devel-opment and commercialization of monospecific antibody candidates using Genmab's HexaBody technology platform. Genmab and BioNTech have four investigational medicines currently in clinical development: DuoBody-CD40x4-1BB (GEN1042/BNT312), DuoBody-PD-L1x4-1BB (GEN1046/BNT311), HexaBody-CD27 (GEN1053/BNT313) and GEN1056 (BNT322). Janssen (DuoBody) In July 2012, Genmab entered into a collaboration with Janssen to create and develop bispecific anti-bodies using our DuoBody technology platform. Under this original agreement, Janssen had the right to use the DuoBody technology platform to create panels of bispecific antibodies (up to 10 DuoBody programs) to multiple disease target combinations. Genmab received an upfront payment of USD 3.5 million from Janssen and will potentially be entitled to milestone and license payments of up to approximately USD 175 million, as well as royalties for each commercialized DuoBody product. Under the terms of a December 2013 amendment, Janssen was entitled to work on up to 10 addi-tional programs. Genmab received an initial payment of USD 2 million from Janssen. For each of the additional programs that Janssen successfully initiates, develops and commer-cializes, Genmab will potentially be entitled to receive average milestone and license payments of approximately USD 191 million. Genmab will be entitled to royalties on sales of any commer-cialized products. All research work is funded by Janssen. Janssen has exercised 14 licenses under this collaboration, not all of which are active, and no further options remain for use by Janssen. As of December 31, 2022, three DuoBody-based products created under this collaboration were in active clinical development. Of these, RYBREVANT and TECVAYLI were the first and second medicines, respectively, created using the DuoBody tech-nology platform to receive regulatory approval. In December 2022, Janssen submitted a BLA to the U.S. FDA for the third product in active clinical development, talquetamab, for the treatment of patients with relapsed or refractory multiple myeloma. Genmab receives milestones and royalties between 8% and 10% for RYBREVANT and milestones and a mid-single digit royalty for TECVAYLI based on Janssen's annual net product sales. Pursuant to the terms of the DuoBody agreement, Janssen's obligation to pay these royalties will expire on a country-by-country and licensed product-by-licensed product basis on the later of the date that is 10 years after the first sale of each licensed product in such country or upon the expiration of the last-to-expire relevant product patent (as defined in the agreement) covering the licensed product in such country. 5.7 Subsequent Events No events have occurred subsequent to the balance sheet date that could significantly affect the financial statements as of December 31, 2022. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag116.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;116 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Parent Company **Table of Contents** Financial Statements of the Parent Company 117 Income Statements 118 Balance Sheets 119 Statements of Cash Flows 120 Statements of Changes in Equity Notes 121 1 Accounting Policies 123 2 Revenue 124 3 Staff Costs 124 4 Corporate and Deferred Tax 125 5 Intangible Assets 126 6 Property and Equipment 127 7 Leases 128 8 Other Investments 128 9 Receivables 128 10 Deferred Revenue 128 11 Other Payables 129 12 Marketable Securities 129 13 Financial Income and Expenses 129 14 Remuneration of the Board of Directors and Executive Management 130 15 Related Party Disclosures 130 16 Investments in Subsidiaries 130 17 Commitments 131 18 Fees to Auditors Appointed at the Annual General Meeting 131 19 Adjustments to Cash Flow Statements |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag117.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;117 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Parent Company (DKK million) Note 2022 2021 Restated\* 2020 Restated\* Revenue (restated\*) 2 14,827 8,606 10,026 Research and development expenses (restated\*) 3, 5, 6 (6277) (3870) (2960) Selling, general and administrative expenses (restated\*) 3, 6 (2728) (1219) (599) Operating expenses (restated\*) (9005) (5089) (3559) Operating profit (restated\*) 5,822 3,517 6,467 Financial income 13 1,300 1,610 254 Financial expenses 13 (369) (254) (1519) Net profit before tax (restated\*) 6,753 4,873 5,202 Corporate tax 4 (1511) (975) (1077) Net profit (restated\*) 5,242 3,898 4,125 \*See Note 1 for details regarding the restatement as a result of errors and change in accounting policies. Income Statements Financial Statements of the Parent Company |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag118.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;118 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Parent Company (DKK million) Note December 31, 2022 December 31, 2021 Restated\* January 1, 2021 Restated\* Assets Intangible assets 5 357 236 304 Property and equipment 6 26 13 10 Right-of-use assets 7 9 12 24 Investments in subsidiaries (restated\*) 16 2,806 2,506 1,954 Receivables 9 35 8 6 Deferred tax assets 4 243 252 177 Other investments 8 66 27 14 Total non-current assets (restated\*) 3,542 3,054 2,489 Corporate tax receivable 4 150 39 250 Receivables 9 5,756 3,187 2,379 Receivables from subsidiaries (restated\*) 9 129 9 73 Marketable securities 12 12,431 10,381 8,819 Cash and cash equivalents 8,830 8,783 7,133 Total current assets (restated\*) 27,296 22,399 18,654 Total assets (restated\*) 30,838 25,453 21,143 Shareholders' Equity and Liabilities Share capital 66 66 66 Share premium 12,309 12,029 11,894 Retained earnings (restated\*) 15,900 11,226 7,423 Total shareholders' equity (restated\*) 28,275 23,321 19,383 Lease liabilities 7 – – 11 Deferred revenue 10 480 487 487 Other payables 11 – 6 5 Total non-current liabilities 480 493 503 Payable to subsidiaries 11 1,136 770 358 Lease liabilities 7 5 11 12 Deferred revenue 10 33 26 26 Other payables 11 909 832 861 Total current liabilities 2,083 1,639 1,257 Total liabilities 2,563 2,132 1,760 Total shareholders' equity and liabilities (restated\*) 30,838 25,453 21,143 \*See Note 1 for details regarding the restatement as a result of errors and change in accounting policies. Balance Sheets Financial Statements of the Parent Company |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag119.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;119 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Parent Company (DKK million) Note 2022 2021 Restated\* 2020 Restated\* Cash flows from operating activities: Net profit before tax (restated\*) 6,753 4,873 5,202 Reversal of financial items, net 13 (931) (1356) 1,265 Adjustment for non-cash transactions (restated\*) 19 172 139 177 Change in operating assets and liabilities (restated\*) 19 (2186) (954) 1,039 Cash provided by operating activities before financial items (restated\*) 3,808 2,702 7,683 Interest received 280 207 170 Interest elements of lease payments 7 – – (1) Interest paid (1) – (11) Corporate taxes (paid)/received (1583) (739) (1476) Net cash provided by operating activities (restated\*) 2,504 2,170 6,365 Cash flows from investing activities: Investment in intangible assets 5 (191) – – Investment in tangible assets 6 (21) (7) (3) Transactions with subsidiaries (restated\*) 374 93 (117) Marketable securities bought (9659) (15514) (12414) Marketable securities sold 7,254 14,469 10,370 Other investments bought (39) (18) – Net cash (used in) investing activities (restated\*) (2282) (977) (2164) Cash flows from financing activities: Warrants exercised 280 135 140 Principal elements of lease payments 7 (13) (13) (12) Purchase of treasury shares (908) (447) – Payment of withholding taxes on behalf of employees on net settled RSUs (88) (50) (25) Net cash provided by (used in) financing activities (729) (375) 103 Changes in cash and cash equivalents (507) 818 4,304 Cash and cash equivalents at the beginning of the period 8,783 7,133 3,274 Exchange rate adjustments 554 832 (445) Cash and cash equivalents at the end of the period 8,830 8,783 7,133 Cash and cash equivalents include: Bank deposits 8,236 8,487 4,927 Short-term marketable securities 594 296 2,206 Cash and cash equivalents at the end of the period 8,830 8,783 7,133 \*See Note 1 for details regarding the restatement as a result of errors and change in accounting policies. Statements of Cash Flows Financial Statements of the Parent Company |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag120.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;120 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Parent Company Statements of Changes in Equity Distribution of the Year's Profit The Board of Directors proposes that the parent company's 2022 net profit of DKK 5,242 million (2021: restated net profit of DKK 3,898 million and 2020: restated net profit of DKK 4,125 million) be carried forward to next year by transfer to retained earnings. Financial Statements of the Parent Company (DKK million) Share capital Share premium Translation Reserves Retained earnings Shareholders' equity Balance at December 31, 2019 65 11,755 98 2,130 14,048 Change in accounting policy – – (98) 949 851 Balance at December 31, 2019 (restated\*) 65 11,755 – 3,079 14,899 Net profit (restated\*) – – – 4,125 4,125 Exercise of warrants 1 139 – – 140 Share-based compensation expenses – – – 200 200 Net settlement of RSUs – – – (25) (25) Tax on items recognized directly in equity – – – 44 44 Balance at December 31, 2020 (restated\*) 66 11,894 – 7,423 19,383 Net profit (restated\*) – – – 3,898 3,898 Exercise of warrants – 135 – – 135 Purchase of treasury shares – – – (447) (447) Share-based compensation expenses – – – 310 310 Net settlement of RSUs – – – (50) (50) Tax on items recognized directly in equity – – – 92 92 Balance at December 31, 2021 (restated\*) 66 12,029 – 11,226 23,321 Net profit – – – 5,242 5,242 Exercise of warrants – 280 – – 280 Purchase of treasury shares – – – (908) (908) Share-based compensation expenses – – – 439 439 Net settlement of RSUs – – – (88) (88) Tax on items recognized directly in equity – – – (11) (11) Balance at December 31, 2022 66 12,309 – 15,900 28,275 \*See Note 1 for details regarding the restatement as a result of errors and change in accounting policies. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag121.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;121 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Parent Company 1 Accounting Policies The financial statements of the parent company have been prepared in accordance with the International Financial Reporting Standards (IFRS) as issued by the International Accounting Standards Board (IASB) and in accordance with IFRS as endorsed by the EU and further require-ments in the Danish Financial Statements Act (Class D). A number of new or amended standards became applicable for the current reporting period. Genmab A/S did not have to change its accounting policies as a result of the adoption of these standards. Refer to Note 1.2 in the consolidated financial statements for a description of new accounting policies and disclosures of the Group. Changes to Accounting Policies Investments in Subsidiaries IFRS standard IAS 27 "Separate Financial Statements" permits investments in subsidiaries to be accounted for either at cost, at fair value in accordance with IFRS 9 "Financial Instruments" or using the equity method as described in IAS 28 "Investments in Associates and Joint Ventures". Effective January 1, 2022, Genmab A/S has elected to measure investments in subsidiaries at cost in the financial statements of the parent company. Previously, investments in subsidiaries were measured using the equity method. This election was made as Genmab A/S has deter-mined that measurement at cost provides more relevant information about the conditions of the parent company financial statements. Under the cost method, investments in subsid-iaries are measured at historical cost. Equity interests in foreign currencies are translated to the reporting currency by use of historical exchange rates prevailing at the time of investment. Additions to the carrying value of investment in subsidiaries include capital contributions made by the parent and share-based payment trans-actions related to employees of the respective subsidiaries based on where the employee has rendered service. Distributions from the investment are recognized as income when declared, if any. If the distri-bution exceeds the current period income or if circumstances or changes in Genmab's operations indicate that the carrying amount of the subsidiary may not be recoverable, the carrying amount is tested for impairment. Where the recoverable amount of the investments is lower than cost, the investments are written down to this lower value. Correction of Prior Period Errors During the period ending December 31, 2022, the parent company revised its income statements and statements of cash flows to correct an error related to share-based compensation expenses recorded by the parent company that should have been reported by its subsidiaries. Under IFRS 2, share-based payment transactions among group entities should be recorded as an expense by the entity that is receiving goods or services. The error resulted in an overstatement of Genmab A/S' share-based compensation expenses and an understatement of (loss) in subsidiaries, net of tax in the prior financial years. In addition, an error was discovered related to cost sharing reimbursements with subsidiaries that were incorrectly recorded as a reduction to revenue. The error resulted in an understate-ment of revenue and research and development expenses, resulting in a revision in the parent company's income statements. The impact of the change in accounting policy and the correction of the prior period errors on the financial statements are shown below. The comparative figures for fiscal years 2021 and 2020 have been restated accordingly. Notes to the Financial Statements of the Parent Company Financial Statements of the Parent Company |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag122.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;122 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Parent Company Notes to the Financial Statements of the Parent Company \| 1 Accounting Policies 2022 2021 2020 (DKK million) Reported Balances Effect of Change in Accounting Policies Balances Before Change in Accounting Policies Restated Balances Effect of Change in Accounting Policies Effect of Error Correction— Share-Based Compensation Expense Effect of Error Correction— Revenue Previously Reported Balances Restated Balances Effect of Change in Accounting Policies Effect of Error Correction— Share-Based Compensation Expense Effect of Error Correction— Revenue Previously Reported Balances Income Statements: Revenue 14,827 – 14,827 8,606 – – 97 8,509 10,026 – – 41 9,985 Research and development expenses (6277) – (6277) (3870) – 184 (97) (3957) (2960) – 122 (41) (3041) Selling, general and administrative expenses (2728) – (2728) (1219) – 77 – (1296) (599) – 38 – (637) Operating expenses (9005) – (9005) (5089) – 261 (97) (5253) (3559) – 160 (41) (3678) Operating profit 5,822 – 5,822 3,517 – 261 – 3,256 6,467 – 160 – 6,307 Profit/(Loss) in subsidiaries, net of tax – (566) 566 – 890 (261) – (629) – (633) (160) – 793 Net profit before tax 6,753 (566) 7,319 4,873 890 – – 3,983 5,202 (633) – – 5,835 Net profit 5,242 (566) 5,808 3,898 890 – – 3,008 4,125 (633) – – 4,758 Adjustment of foreign currency fluctuations on subsidiaries – (41) 41 – (27) – – 27 – 44 – – (44) Balance Sheets: Investments in subsidiaries 2,806 891 1,915 2,506 1,195 – – 1,311 1,954 332 – – 1,622 Total non-current assets 3,542 891 2,651 3,054 1,195 – – 1,859 2,489 332 – – 2,157 Receivables from subsidiaries 129 – 129 9 (70) – 79 73 (70) – 143 Total current assets 27,296 – 27,296 22,399 (70) – – 22,469 18,654 (70) – – 18,724 Total assets 30,838 891 29,947 25,453 1,125 – – 24,328 21,143 262 – 20,881 Other reserves – (122) 122 – (81) – – 81 – (54) – – 54 Retained earnings 15,900 1,013 14,887 11,226 1,206 – – 10,020 7,423 316 – – 7,107 Total shareholders' equity 28,275 891 27,384 23,321 1,125 – – 22,196 19,383 262 – – 19,121 Total shareholders' equity and liabilities 30,838 891 29,947 25,453 1,125 – – 24,328 21,143 262 – – 20,881 Statements of Cash Flows: Net profit before tax 6,753 (566) 7,319 4,873 890 – – 3,983 5,202 (633) – – 5,835 Reversal of profit/(loss) in subsidiaries, net of tax – 566 (566) – (890) 261 – 629 – 633 160 – (793) Adjustment for non-cash transactions 172 – 172 139 – (261) – 400 177 – (160) – 337 Change in operating assets and liabilities (2186) – (2186) (954) 70 – – (1024) 1,039 70 – – 969 Cash provided by operating activities before financial items 3,808 – 3,808 2,702 70 – – 2,632 7,683 70 – – 7,613 Net cash provided by operating activities 2,504 – 2,504 2,170 70 – – 2,100 6,365 70 – – 6,295 Transactions with subsidiaries 374 – 374 93 (70) – – 163 (117) (70) – – (47) Net cash (used in) investing activities (2282) – (2282) (977) (70) – – (907) (2164) (70) – – (2094) |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag123.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;123 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Parent Company Notes to the Financial Statements of the Parent Company \| 2 Revenue Supplementary Accounting Policies for the Parent Company Investments in Subsidiaries The cost method is used for measuring the invest-ments in subsidiaries. Under the cost method, investments in subsidiaries are measured at historical cost. Equity interests in foreign curren-cies are translated to the reporting currency by use of historical exchange rates prevailing at the time of investment. Additions to the carrying value of investment in subsidiaries include capital contributions made by the parent and share-based payment trans-actions related to employees of the respective subsidiaries based on where the employee has rendered service. Distributions from the investment are recognized as income when declared, if any. If the distri-bution exceeds the current period income or if circumstances or changes in Genmab's operations indicate that the carrying amount of the subsid-iary may not be recoverable, the carrying amount is tested for impairment. Where the recoverable amount of the investments is lower than cost, the investments are written down to this lower value. Refer to Note 1.1 in the consolidated financial statements for a description of the accounting policies of the Group. Refer to Note 1.3 in the consolidated financial statements for a description of management's judgements and estimates under IFRS 2 Revenue (DKK million) 2022 2021 2020 Revenue by type: Royalties 11,672 6,977 4,741 Reimbursement revenue 1,050 655 517 Milestone revenue 1,767 954 351 License revenue 6 – 4,417 Collaboration revenue 332 20 – Total 14,827 8,606 10,026 Revenue by collaboration partner: Janssen 10,620 6,847 4,693 AbbVie 1,174 245 4,227 Roche 796 603 305 Novartis 815 236 212 BioNTech 708 416 230 Seagen 413 135 201 Other 301 124 158 Total 14,827 8,606 10,026 Royalties by product: DARZALEX 10,056 6,135 4,419 TEPEZZA 796 593 298 Kesimpta 779 235 10 Other 41 14 14 Total 11,672 6,977 4,741 Refer to Note 2.1 in the consolidated financial statements for additional information regarding revenue of the Group. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag124.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;124 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Parent Company Notes to the Financial Statements of the Parent Company \| 3 Staff Costs 3 Staff Costs (DKK million) 2022 2021 2020 Wages and salaries 392 277 182 Share-based compensation 68 49 35 Defined contribution plans 29 22 15 Other social security costs 25 15 21 Total 514 363 253 Staff costs are included in the income statement as follows: Research and development expenses 393 271 191 Selling, general and administrative expenses 121 92 62 Total 514 363 253 Average number of FTE 348 269 180 Number of FTE at year-end 385 312 210 Refer to Note 2.3 in the consolidated financial statements for additional information regarding staff costs of the Group. 4 Corporate and Deferred Tax Taxation—Income Statement & Shareholders' Equity (DKK million) 2022 2021 2020 Current tax Current tax on profit 1,508 959 1,190 Adjustment to deferred tax 3 16 (113) Total tax for the period in the income statement 1,511 975 1,077 A reconciliation of Genmab's effective tax rate relative to the Danish statutory tax rate is as follows: (DKK million) 2022 2021 2020 Net profit before tax 6,753 4,873 5,202 Tax at the Danish statutory corporation tax rate of 22% for all periods 1,486 1,072 1,144 Tax effect of: Non-deductible expenses/non-taxable income and other permanent differences, net 37 (105) (61) All other (12) 8 (6) Total tax effect 25 (97) (67) Total tax for the period in the income statement 1,511 975 1,077 Total tax for the period in shareholders' equity (22) (31) (44) Effective Tax Rate 22.4% 20.0% 20.7% |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag125.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;125 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Parent Company Notes to the Financial Statements of the Parent Company \| 5 Intangible Assets Taxation—Balance Sheet Significant components of the deferred tax asset are as follows: (DKK million) 2022 2021 Share-based instruments 124 130 Deferred revenue 113 113 Other temporary differences 6 9 Total deferred tax assets 243 252 Refer to Note 2.4 in the consolidated financial statements for additional information regarding corporate and deferred tax of the Group. 5 Intangible Assets Licenses, Rights, and Patents (DKK million) 2022 2021 Cost at January 1 820 820 Additions for the year 191 – Cost at December 31 1,011 820 Accumulated amortization and impairment at January 1 (584) (516) Amortization for the year (63) (72) Accumulated amortization (7) 4 Accumulated amortization and impairment at December 31 (654) (584) Carrying amount at December 31 357 236 (DKK million) 2022 2021 2020 Amortization and impairment included in the income statement as follows: Research and development expenses 63 72 119 Total 63 72 119 Parent Company intangible assets include licenses and rights primarily to gain access to targets and technologies identified by third parties as well as subsidiaries. Refer to Note 3.1 in the consolidated financial statements for additional information regarding intangible assets of the Group. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag126.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;126 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Parent Company Notes to the Financial Statements of the Parent Company \| 6 Property and Equipment 6 Property and Equipment (DKK million) Leasehold improvements Equipment, furniture and fixtures Assets under construction Total property and equipment 2022 Cost at January 1 4 25 6 35 Additions for the year – 6 11 17 Disposals for the year – (7) – (7) Cost at December 31 4 24 17 45 Accumulated depreciation and impairment at January 1 (3) (19) – (22) Depreciation for the year (1) (5) – (6) Disposals for the year – 9 – 9 Accumulated depreciation and impairment at December 31 (4) (15) – (19) Carrying amount at December 31 – 9 17 26 2021 Cost at January 1 4 23 – 27 Additions for the year – 2 6 8 Cost at December 31 4 25 6 35 Accumulated depreciation and impairment at January 1 (2) (15) – (17) Depreciation for the year (1) (4) – (5) Accumulated depreciation and impairment at December 31 (3) (19) – (22) Carrying amount at December 31 1 6 6 13 (DKK million) 2022 2021 2020 Depreciation and impairment included in the income statement as follows: Research and development expenses 2 3 3 Selling, general and administrative expenses 4 2 2 Total 6 5 5 Refer to Note 3.2 in the consolidated financial statements for additional information regarding property and equipment of the Group. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag127.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;127 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Parent Company Notes to the Financial Statements of the Parent Company \| 7 Leases 7 Leases The parent company has entered into lease agreements with respect to office space. The leases are non-cancellable over various periods through 2038. (DKK million) December 31, 2022 December 31, 2021 December 31, 2020 Right-of-use assets Balance at January 1 12 24 34 Additions to right-of-use assets1 10 1 3 Depreciation charge for the year (13) (13) (13) Balance at December 31 9 12 24 Lease liabilities Current 5 11 12 Non-current – – 11 Total lease liabilities 5 11 23 Cash outflow for lease payments 13 13 13 1. Additions to right-of-use assets also includes modifications to existing leases and adjustments to the provisions for contractual restoration obligations related to leases of Genmab offices. Variable lease payments and lease interest expense are immaterial. Future minimum payments under leases as of December 31, 2022, December 31, 2021 and December 31, 2020, are as follows: (DKK million) 2022 2021 2020 Payment due Less than 1 year 5 11 12 1 to 3 years – – 12 More than 3 years but less than 5 years – – – More than 5 years – – – Total 5 11 24 Future minimum payments under leases with commencement dates after December 31, 2022 are not included in the table above. Significant leases not yet commenced During 2020, Genmab entered into a lease agreement with respect to the new headquarters in Denmark with a commencement date in March 2023 and is non-cancellable until March 2038. The total future minimum payments over the term of the lease are approximately DKK 339 million and estimated capital expenditures to fit out the space are approximately DKK 128 million. Refer to Note 3.3 in the consolidated financial statements for additional information regarding leases of the Group. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag128.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;128 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Parent Company Notes to the Financial Statements of the Parent Company \| 8 Other Investments 8 Other Investments Refer to Note 3.4 to the consolidated financial statements for additional information on other investments of the Group. 9 Receivables (DKK million) 2022 2021 Receivables related to collaboration agreements 5,257 2,979 Receivables from subsidiaries 129 9 Interest receivables 83 37 Other receivables 77 52 Receivables for securities matured 290 – Prepayments 84 127 Total 5,920 3,204 Non-current receivables 35 8 Current receivables 5,885 3,196 Total 5,920 3,204 Refer to Note 3.5 in the consolidated financial statements for additional information regarding receivables of the Group. 10 Deferred Revenue (DKK million) 2022 2021 Deferred revenue at January 1 513 513 Customer payment received – – Revenue recognized during the year – – Total at December 31 513 513 Non-current deferred revenue 480 487 Current deferred revenue 33 26 Total at December 31 513 513 Refer to Note 3.6 in the consolidated financial statements for additional information regarding deferred revenue of the Group. 11 Other Payables (DKK million) 2022 2021 Liabilities related to collaboration agreements 70 53 Staff cost liabilities 90 67 Other liabilities 653 577 Payable to subsidiaries 1,136 770 Provisions 6 6 Accounts payable 90 135 Total at December 31 2,045 1,608 Non-current other payables – 6 Current other payables 2,045 1,602 Total at December 31 2,045 1,608 Refer to Note 3.7 in the consolidated financial statements for additional information regarding other payables of the Group. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag129.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;129 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Parent Company Notes to the Financial Statements of the Parent Company \| 12 Marketable Securities 12 Marketable Securities Refer to Note 4.4 to the consolidated financial statements for additional information on marketable securities of the Group. 13 Financial Income and Expenses (DKK million) 2022 2021 2020 Financial income: Interest and other financial income 321 190 184 Interest from subsidiaries – 3 – Gain on other investments, net 1 – 70 Foreign exchange rate gain, net 978 1,417 – Total financial income 1,300 1,610 254 Financial expenses: Interest and other financial expenses (6) (1) (2) Interest to subsidiaries (2) – (3) Loss on marketable securities, net (361) (246) (91) Loss on other investments, net – (7) – Foreign exchange rate loss, net – – (1423) Total financial expenses (369) (254) (1519) Net financial items 931 1,356 (1265) Refer to Note 4.5 in the consolidated financial statements for additional information regarding financial income and expenses of the Group. 14 Remuneration of the Board of Directors and Executive Management Remuneration of the Board of Directors for the parent is the same as the Group. Remuneration of Executive Management for the parent company is 10% of total compensation for each member of Executive Management as reported in Note 5.1 in the consolidated financial statements, per service agreement with each member of Executive Management. Refer to Note 5.1 in the consolidated financial statements for additional information regarding the remuneration of the Board of Directors and Executive Management. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag130.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;130 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Parent Company Notes to the Financial Statements of the Parent Company \| 15 Related Party Disclosures 15 Related Party Disclosures Genmab A/S' related parties are the parent company's subsidiaries, Board of Directors, Executive Management, and close members of the family of these persons. Transactions With Subsidiaries Genmab B.V., Genmab Holding B.V., Genmab US, Inc. and Genmab K.K. are 100% (directly or indirectly) owned subsidiaries of Genmab A/S and are included in the consolidated financial statements. During 2022, various intercompany transactions and services between the aforementioned companies took place in the field of research and development, selling, general and administration, finance and management. All intercompany transactions have been eliminated in the consolidated financial state-ments of the Genmab Group. (DKK million) 2022 2021 2020 Transactions with subsidiaries: Income statement: Service fee income 233 221 127 Service fee costs (4446) (2675) (1693) Milestone costs (1090) – – Financial income – 3 – Financial expense (2) – (3) Balance sheet: Intangible assets 217 33 40 Current receivables 129 9 73 Current payables (1136) (770) (358) Genmab A/S has placed at each subsidiary's disposal a credit facility (denominated in local currency) that the subsidiary may use to draw from in order to secure the necessary funding of its activities. Refer to Note 5.2 to the consolidated financial statements for additional information regarding transactions with related parties of the Group. 16 Investments in Subsidiaries (DKK million) 2022 2021 Cost at January 1 4,435 3,885 Additions 300 550 Cost at December 31 4,735 4,435 Impairment at January 1 (1929) (1929) Impairment at December 31 (1929) (1929) Carrying amount at December 31 2,806 2,506 Refer to Note 1.1 in the consolidated financial statements for a listing of subsidiaries owned by Genmab A/S. Refer to Note 1 in the parent financial statements for details of change in accounting policies impacting Genmab A/S investment in subsidiaries. 17 Commitments Purchase Obligations Genmab A/S has entered into a number of agreements related to research and development activities that contain various obligations. These short-term contractual obligations amounted to approximately DKK 1,558 million as of December 31, 2022, all of which is due in less than two years (2021: approxi-mately DKK 1,207 million). Genmab A/S also has certain contingent commitments under our license and collaboration agreements that may become due in the future. As of December 31, 2022, these contingent commitments amounted to approximately DKK 14,537 million (USD 2,085 million) in potential future development, regulatory and commercial milestone payments to third parties under license and collaboration agreements for our pre-clinical and clinical stage development programs as compared to approximately DKK 14,371 million  |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag131.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;131 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Financial Statements \| Parent Company Notes to the Financial Statements of the Parent Company \| 18 Fees to Auditors Appointed at the Annual General Meeting (USD 2,190 million) as of December 31, 2021. These milestone payments generally become due and payable only upon the achievement of certain development, clinical, regulatory or commercial mile-stones. The events triggering such payments or obligations have not yet occurred. In addition to the above obligations, Genmab A/S enters into a variety of agreements and financial commitments in the normal course of business. The terms generally allow us the option to cancel, reschedule and adjust our requirements based on our business needs prior to the delivery of goods or performance of services. It is not possible to predict the maximum potential amount of future payments under these agreements due to the conditional nature of our obligations and the unique facts and circumstances involved in each particular agreement. Refer to Note 5.3 in the consolidated financial statements for additional information regarding commitments of the Group. 18 Fees to Auditors Appointed at the Annual General Meeting (DKK million) 2022 2021 2020 PricewaterhouseCoopers Audit services 5.8 5.8 4.9 Audit-related services 2.0 1.8 1.0 Tax and VAT services – – 0.3 Total 7.8 7.6 6.2 Fees for other services than statutory audit of the financial statements provided by PricewaterhouseCoopers Statsautoriseret Revisionspartnerselskab amounted to DKK 2.0 million in 2022 (DKK 1.8 million in 2021 and DKK 1.3 million in 2020, respectively). These services primarily include agreed-upon procedures, other assurance assessments and reports, accounting advice, and tax and VAT compliance. Refer to Note 5.4 in the consolidated financial statements for additional information regarding fees to auditors of the Group. 19 Adjustments to Cash Flow Statements (DKK million) Note 2022 2021 2020 Adjustments for non-cash transactions: Depreciation, amortization and impairment 5, 6, 7 110 90 137 Share-based compensation expenses 3 62 49 40 Total adjustments for non-cash transactions 172 139 177 Change in operating assets and liabilities: Receivables (2286) (923) 390 Deferred revenue – – 513 Other payables 100 (31) 136 Total change in operating assets and liabilities (2186) (954) 1,039 Refer to Note 5.5 in the consolidated financial statements for additional information regarding adjustments to the cash flow statement of the Group. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag132.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;132 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Directors' and Management's Statement on the Annual Report The Board of Directors and Executive Management have today considered and adopted the Annual Report of Genmab A/S for the financial year January 1 to December 31, 2022. The Annual Report has been prepared in accor-dance with International Financial Reporting Standards (IFRS) as issued by the International Accounting Standards Board (IASB) and in accordance with IFRS as endorsed by the EU and further requirements in the Danish Financial Statements Act. In our opinion, the Consolidated Financial Statements and the Parent Company Financial Statements give a true and fair view of the financial position at December 31, 2022 of the Group and the Parent Company and of the results of the Group and Parent Company operations and cash flows for 2022. In our opinion, Management's Review includes a true and fair account of the development in the operations and financial circumstances of the Group and the Parent Company, of the results for the year and of the financial position of the Group and the Parent Company as well as a description of the most significant risks and elements of uncertainty facing the Group and the Parent Company. In our opinion, the Annual Report of Genmab A/S for the financial year January 1 to December 31, 2022, with the file name 529900MTJPDPE4MHJ122-2022-12-31-en.zip is prepared, in all material respects, in compliance with the ESEF Regulation. We recommend that the Annual Report be adopted at the Annual General Meeting. Copenhagen, February 22, 2023 Directors' and Management's Statement on the Annual Report Executive Management Jan van de Winkel (President & CEO) Anthony Pagano (Executive Vice President & CFO) Judith Klimovsky (Executive Vice President & CDO) Anthony Mancini (Executive Vice President & COO) Tahamtan Ahmadi (Executive Vice President & CMO) Board of Directors Deirdre P. Connelly (Chair) Pernille Erenbjerg (Deputy Chair) Anders Gersel Pedersen Rolf Hoffmann Paolo Paoletti Elizabeth O'Farrell Mijke Zachariasse (Employee elected) Takahiro Hamatani (Employee elected) Martin Schultz (Employee elected) |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag133.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;133 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Independent Auditor's Reports To the shareholders of Genmab A/S Report on the Audit of the Financial Statements Our opinion In our opinion, the Consolidated Financial Statements and the Parent Company Financial Statements give a true and fair view of the Group's and the Parent Company's financial position at December 31, 2022 and of the results of the Group's and the Parent Company's operations and cash flows for the financial year January 1 to December 31, 2022 in accordance with International Financial Reporting Standards as issued by the International Accounting Standards Board and International Financial Reporting Standards as adopted by the EU and further require-ments in the Danish Financial Statements Act. Our opinion is consistent with our Auditor's Long-form Report to the Audit and Finance Committee and the Board of Directors. What we have audited The Consolidated Financial Statements and Parent Company Financial Statements of Genmab A/S for the financial year January 1 to December 31, 2022 comprise statement of comprehensive income, balance sheet, statement of cash flows, statement of changes in equity and notes, including summary of significant accounting policies for the Group as well as for the Parent Company. Collectively referred to as the "Financial Statements". Basis for opinion We conducted our audit in accordance with International Standards on Auditing (ISAs) and the additional requirements applicable in Denmark. Our responsibilities under those standards and requirements are further described in the Auditor's responsibilities for the audit of the Financial Statements section of our report. We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our opinion. Independence We are independent of the Group in accordance with the International Ethics Standards Board for Accountants' International Code of Ethics for Professional Accountants (IESBA Code) and the additional ethical requirements applicable in Denmark. We have also fulfilled our other ethical responsibilities in accordance with these require-ments and the IESBA Code. To the best of our knowledge and belief, prohib-ited non-audit services referred to in Article 5(1) of Regulation (EU) No 537/2014 were not provided. Appointment Following the listing of the shares of Genmab A/S on Nasdaq Copenhagen, we were first appointed auditors of Genmab A/S on March 22, 2001 for the financial year 2001. We have been reap-pointed annually by shareholder resolution for a total period of uninterrupted engagement of 22 years including the financial year 2022. Key audit matters Key audit matters are those matters that, in our professional judgement, were of most significance in our audit of the Financial Statements for 2022. These matters were addressed in the context of our audit of the Financial Statements as a whole, and in forming our opinion thereon, and we do not provide a separate opinion on these matters. Independent Auditor's Reports Key audit matter Revenue recognition of DARZALEX FASPRO In June 2022, the Group commenced binding arbitration of matters arising under its license agreement with Janssen Biotech, Inc. (Janssen) relating to DARZALEX FASPRO. The arbitration is to settle whether Janssen is to pay milestone payments for the DARZALEX FASPRO as a separate product, and whether the Group is entitled to a new 13-year royalty term from the date of DARZALEX FASPRO's first commercial sale. Based on discussions with in-house legal counsel, the Group has considered revenue subject to this arbitration as a variable consideration where it is not highly probable that the Group will not reverse this revenue in the future. Therefore, the Group has not recognized revenue in relation to the milestone payments, subject to the arbitration. The milestone payments constitute approximately DKK 2.8 billion (USD 405 million). In relation to the revenue recognition of DARZALEX FASPRO it requires that Management make a significant judgement when determining the estimate of the variable consideration. We focused on the revenue recognition of DARZALEX FASPRO because estimating the variable consideration requires significant judgement by Management. Reference is made to Note 5.6 in the Consolidated Financial Statements. How our audit addressed the key audit matter We tested certain internal controls over the process to record revenue, including controls related to the estimate of the variable consideration. We evaluated and tested Management's process for determining the variable consider-ation and assessing the reasonableness of the estimate. This included (i) gaining an under-standing of the Company's process around the accounting and reporting for the arbitration; (ii) discussing the status of the arbitration with the Company's in-house legal counsel as well as obtaining legal letter from the external legal counsel; (iii) evaluating the reasonableness of Management's estimate regarding recognition of the variable consideration; and (iv) evalu-ating the presentation and disclosure within the Financial Statements. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag134.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;134 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Independent Auditor's Reports Statement on Management's Review Management is responsible for Management's Review. Our opinion on the Financial Statements does not cover Management's Review, and we do not express any form of assurance conclu-sion thereon. In connection with our audit of the Financial Statements, our responsibility is to read Management's Review and, in doing so, consider whether Management's Review is materially inconsistent with the Financial Statements, or our knowledge obtained in the audit, or otherwise appears to be materially misstated. Moreover, we considered whether Management's Review includes the disclosures required by the Danish Financial Statements Act. Based on the work we have performed, in our view, Management's Review is in accordance with the Consolidated Financial Statements and the Parent Company Financial Statements and has been prepared in accordance with the require-ments of the Danish Financial Statements Act. We did not identify any material misstatement in Management's Review. Management's responsibilities for the Financial Statements Management is responsible for the preparation of consolidated financial statements and parent company financial statements that give a true and fair view in accordance with International Financial Reporting Standards as adopted by the EU and further requirements in the Danish Financial Statements Act, and for such internal control as Management determines is necessary to enable the preparation of financial statements that are free from material misstatement, whether due to fraud or error. In preparing the Financial Statements, Management is responsible for assessing the Group's and the Parent Company's ability to continue as a going concern, disclosing, as appli-cable, matters related to going concern and using the going concern basis of accounting unless Management either intends to liquidate the Group or the Parent Company or to cease operations, or has no realistic alternative but to do so. Auditor's responsibilities for the audit of the Financial Statements Our objectives are to obtain reasonable assurance about whether the Financial Statements as a whole are free from material misstatement, whether due to fraud or error, and to issue an auditor's report that includes our opinion. Reasonable assurance is a high level of assurance but is not a guarantee that an audit conducted in accordance with ISAs and the additional requirements applicable in Denmark will always detect a material misstatement when it exists. Misstatements can arise from fraud or error and are considered material if, individually or in the aggregate, they could reasonably be expected to influence the economic decisions of users taken on the basis of these Financial Statements. As part of an audit in accordance with ISAs and the additional requirements applicable in Denmark, we exercise professional judgement and maintain professional skepticism throughout the audit. We also: • Identify and assess the risks of material misstatement of the Financial Statements, whether due to fraud or error, design and perform audit procedures responsive to those risks, and obtain audit evidence that is sufficient and appropriate to provide a basis for our opinion. The risk of not detecting a material misstatement resulting from fraud is higher than for one resulting from error, as fraud may involve collusion, forgery, intentional omissions, misrepresentations, or the override of internal control. • Obtain an understanding of internal control relevant to the audit in order to design audit procedures that are appropriate in the circumstances, but not for the purpose of expressing an opinion on the effectiveness of the Group's and the Parent Company's internal control. • Evaluate the appropriateness of accounting policies used and the reasonableness of accounting estimates and related disclosures made by Management. • Conclude on the appropriateness of Management's use of the going concern basis of accounting and based on the audit evidence obtained, whether a material uncertainty exists related to events or conditions that may cast significant doubt on the Group's and the Parent Company's ability to continue as a going concern. If we conclude that a material uncertainty exists, we are required to draw attention in our auditor's report to the related disclosures in the Financial Statements or, if such disclosures are inadequate, to modify our opinion. Our conclusions are based on the audit evidence obtained up to the date of our auditor's report. However, future events or conditions may cause the Group or the Parent Company to cease to continue as a going concern. • Evaluate the overall presentation, structure and content of the Financial Statements, including the disclosures, and whether the Financial Statements represent the underlying transactions and events in a manner that gives a true and fair view. • Obtain sufficient appropriate audit evidence regarding the financial information of the entities or business activities within the Group to express an opinion on the Consolidated Financial Statements. We are responsible for the direction, supervision and performance of the group audit. We remain solely responsible for our audit opinion. We communicate with those charged with governance regarding, among other matters, the planned scope and timing of the audit and significant audit findings, including any significant deficiencies in internal control that we identify during our audit. Independent Auditor's Reports \| Report on the Audit of the Financial Statements |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag135.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;135 **Table of Contents** Management's Review Financial Statements Other Information Genmab \| 2022 Annual Report \| Independent Auditor's Reports We also provide those charged with governance with a statement that we have complied with relevant ethical requirements regarding inde-pendence, and to communicate with them all relationships and other matters that may reason-ably be thought to bear on our independence, and where applicable, actions taken to eliminate threats or safeguards applied. From the matters communicated with those charged with governance, we determine those matters that were of most significance in the audit of the Financial Statements of the current period and are therefore the key audit matters. We describe these matters in our auditor's report unless law or regulation precludes public disclo-sure about the matter. Report on Compliance with the ESEF Regulation As part of our audit of the Financial Statements we performed procedures to express an opinion on whether the annual report of Genmab A/S for the financial year January 1 to December 31, 2022 with the file name 529900MTJPDPE4MHJ122-2022-12-31-en. zip is prepared, in all material respects, in compliance with the Commission Delegated Regulation (EU) 2019/815 on the European Single Electronic Format (ESEF Regulation) which includes requirements related to the preparation of the annual report in XHTML format and iXBRL tagging of the Consolidated Financial Statements including notes. Management is responsible for preparing an annual report that complies with the ESEF Regulation. This responsibility includes: • The preparing of the annual report in XHTML format; • The selection and application of appropriate iXBRL tags, including extensions to the ESEF taxonomy and the anchoring thereof to elements in the taxonomy, for all financial information required to be tagged using judgement where necessary; • Ensuring consistency between iXBRL tagged data and the Consolidated Financial Statements presented in human-readable format; and • For such internal control as Management determines necessary to enable the preparation of an annual report that is compliant with the ESEF Regulation. Our responsibility is to obtain reasonable assurance on whether the annual report is prepared, in all material respects, in compliance with the ESEF Regulation based on the evidence we have obtained, and to issue a report that includes our opinion. The nature, timing and extent of procedures selected depend on the auditor's judgement, including the assessment of the risks of material departures from the require-ments set out in the ESEF Regulation, whether due to fraud or error. The procedures include: • Testing whether the annual report is prepared in XHTML format; • Obtaining an understanding of the company's iXBRL tagging process and of internal control over the tagging process; • Evaluating the completeness of the iXBRL tagging of the Consolidated Financial Statements including notes; • Evaluating the appropriateness of the company's use of iXBRL elements selected from the ESEF taxonomy and the creation of extension elements where no suitable element in the ESEF taxonomy has been identified; • Evaluating the use of anchoring of extension elements to elements in the ESEF taxonomy; and • Reconciling the iXBRL tagged data with the audited Consolidated Financial Statements. In our opinion, the annual report of Genmab A/S for the financial year January 1 to December 31, 2022 with the file name 529900MTJPDPE4MHJ122-2022-12-31-en.zip is prepared, in all material respects, in compliance with the ESEF Regulation. Hellerup, February 22, 2023 PricewaterhouseCoopers Statsautoriseret Revisionspartnerselskab CVR no 3377 1231 Torben Jensen State Authorised Public Accountant mne18651 Henrik Trangeled Kristensen State Authorised Public Accountant mne23333 Independent Auditor's Reports \| Report on Compliance with the ESEF Regulation |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag136.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Management's Review Financial Statements **Table of Contents** Other Information Financial Statements 136 Genmab \| 2022 Annual Report \| Other Information Other Information In this section 137 Glossary 138 Forward-looking Statement 139 Contact Information |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag137.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;137 Management's Review Financial Statements **Table of Contents** Other Information Genmab \| 2022 Annual Report \| Other Information Financial Statements American Depository Shares (ADSs) A U.S. dollar-denominated equity share of a foreign-based company available for purchase on an American stock exchange. Antibody-drug conjugate (ADC) Antibody with potent cytotoxic agents (toxins) coupled to it. Antigen Immunogen. A target molecule that is specifically bound by an antibody. Apoptosis A form of programmed cell death. Biologics License Application (BLA) A submission to apply for marketing approval from the U.S. FDA, which contains specific information on the manufacturing processes, chemistry, phar-macology, clinical pharmacology and the medical effects of a biologic product. Bispecific antibody An antibody in which the two binding regions are not identical, with each region directed against two different antigens or against two different sites on the same antigen. Building Research Establishment Environmental Assessment Method (BREEAM) A sustainability assessment method for infra-structure and buildings. Clinical Term used to refer to drugs that are at the stage of being investigated in humans to determine the safety and efficacy of the drug before it can be submitted for approval by regulatory authorities. Complement dependent cytotoxicity (CDC) An antibody effector function that eliminates target cells. Corporate Social Responsibility (CSR) Business model that enables a corporation to be socially accountable to itself, its stakeholders and its community. Cytotoxic Toxic to living cells. Dual-listed company A company whose shares are traded on two stock markets. Epitope The specific surface portion of an antigen to which an antibody binds. Upon binding of the antibody to the epitope an immune response is elicited. Environmental, Social and Governance (ESG) Set of standards for a company's operations. European Medicines Agency (EMA) European regulatory agency that facilitates development and access to medicines, evaluates applications for marketing authorization and monitors the safety of medicines. Hexamerization The ordered clustering of six antibodies. Immunomodulatory agent A type of drug used to treat certain types of cancers, such as multiple myeloma. Examples include lenalidomide and pomalidomide. Leadership in Energy and Environmental Design (LEED) Globally recognized green building rating system. Monoclonal Derived from a single cell. Monoclonal antibodies derived from such single cell will be identical. Monotherapy Treatment of a medical condition by use of a single drug. Pre-clinical Term used to refer to products that are at the stage of being investigated in the laboratory or in animals to determine the safety and efficacy of the product before it is evaluated in humans. Priority Review U.S. FDA designation used for drugs that, if approved, would be significant improvements in the safety or effectiveness of the treatment, diagnosis, or prevention of serious conditions when compared to standard applications. Progression free survival (PFS) Progression free survival. The length of time a patient lives without his/her disease worsening. Proteasome inhibitor (PI) A type of drug used to treat certain types of cancer, such as multiple myeloma. Examples include bortezomib and carfilzomib. Subcutaneous (SC) Applied under the skin. Target A molecule of potential interest against which an antibody is raised/created. Transgenic mouse A mouse carrying a transgene from a foreign species, typically a human, which transgene has been introduced into the replicating cells of the mouse, so the transgene is passed on to future generations/offspring of the transgenic mouse. U.S. Food and Drug Administration (U.S. FDA) U.S. regulatory agency responsible for ensuring the safety, efficacy and security of human and veterinary drugs, biological products and medical devices. Glossary |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag138.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;138 Management's Review Financial Statements **Table of Contents** Other Information Genmab \| 2022 Annual Report \| Other Information Financial Statements Forward-looking Statement This Annual Report contains forward looking statements. The words "believe," "expect," "anticipate," "intend" and "plan" and similar expressions identify forward looking statements. Actual results or performance may differ materially from any future results or performance expressed or implied by such statements. The important factors that could cause our actual results or performance to differ materially include, among others, risks associated with product discovery and development, uncertainties related to the outcome and conduct of clinical trials including unforeseen safety issues, uncertainties related to product manufacturing, our inability to manage growth, the competitive environment in relation to our business area and markets, our inability to attract and retain suitably qualified personnel, the unenforceability or lack of protection of our patents and proprietary rights, our relationships with affiliated entities, changes and developments in technology which may render our products obsolete, and other factors. Additional factors that could cause our actual results or performance to differ materially could also include and are not limited to the risk and uncertainties related to regulatory action, reimbursement, market adoption by physicians or lack of market acceptance of our products, the risk that the company or our collaborators may be delayed or unsuccessful in planned clinical trial initiations, enrollment and planned regulatory submissions and approvals in the U.S. and other countries. For a further discussion of these risks, please refer to the section "Risk Management" in this Annual Report and the risk factors included in Genmab's 2022 Annual Report on Form 20-F and other filings with the U.S. Securities and Exchange Commission (SEC). Genmab does not undertake any obligation to update or revise forward looking statements in this Annual Report nor to confirm such statements to reflect subsequent events or circumstances after the date made or in relation to actual results, unless required by law. Genmab A/S and/or its subsidiaries own the following trademarks: Genmab®; the Y-shaped Genmab logo®; Genmab in combination with the Y-shaped Genmab logo®; HuMax®; DuoBody®; DuoBody in combination with the DuoBody logo®; HexaBody®; HexaBody in combination with the HexaBody logo®; DuoHexaBody® and HexElect®. Tivdak® is a trademark of Seagen Inc.; Arzerra® is a trademark of Novartis Pharma AG. Kesimpta® and Sensoready® are trademarks of Novartis AG or its affiliates; DARZALEX®, DARZALEX FASPRO®, RYBREVANT®, and TECVAYLI® are trademarks of Johnson & Johnson; EPCORE™ is a trademark of AbbVie Biotechnology Ltd.; TEPEZZA® is a trademark of Horizon Therapeutics Ireland DAC.©2023, Genmab A/S. All rights reserved. Photograph credits: Andrei Jackamets Tuala Hjarnø 3FX, Inc. About Genmab A/S Genmab is an international biotechnology company with a core purpose guiding its unstoppable team to strive towards improving the lives of patients through innovative and differentiated antibody therapeutics. For more than 20 years, its passionate, innovative and collaborative team has invented next-generation antibody technology platforms and leveraged translational research and data sciences, which has resulted in a proprietary pipeline including bispecific T-cell engagers, next-generation immune checkpoint modulators, effector function enhanced antibodies and antibody-drug conjugates. To help develop and deliver novel antibody therapies to patients, Genmab has formed 20+ strategic partnerships with biotechnology and pharmaceutical companies. By 2030, Genmab's vision is to transform the lives of people with cancer and other serious diseases with Knock-Your-Socks-Off (KYSO) antibody medicines. Established in 1999, Genmab is headquartered in Copenhagen, Denmark with locations in Utrecht, the Netherlands, Princeton, New Jersey, U.S. and Tokyo, Japan. For more information, please visit Genmab.com and follow us on Twitter.com/Genmab. |

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| &nbsp;&nbsp;![GRAPHIC](gmab-20221231xex99d1ag139.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;139 Management's Review Financial Statements **Table of Contents** Other Information Genmab \| 2022 Annual Report \| Other Information Financial Statements Contact Information Genmab A/S Kalvebod Brygge 43 1560 Copenhagen V Denmark T. +45 70 20 27 28 Genmab US, Inc. 777 Scudders Mill Road Plainsboro, NJ 08536 USA T. +1 609 430 2481 Genmab B.V. & Genmab Holding B.V. Uppsalalaan 15 3584 CT Utrecht The Netherlands T. +31 30 2 123 123 Genmab K.K. 35F Midtown Tower 9-7-1 Akasaka, Minato-ku Tokyo 107-6235 Japan T. +81 3 5403 6330 LEI Code 529900MTJPDPE4MHJ122 www.genmab.com |

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