# EDGAR Filing Document

**Accession Number:** 0000872625
**File Stem:** 0002071691-26-007599
**Filing Date:** 2026-3
**Character Count:** 39734
**Document Hash:** 3503539997fa4ae249fd426dde96892c
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0002071691-26-007599.hdr.sgml**: 20260327

**ACCESSION NUMBER**: 0002071691-26-007599

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20260131

**FILED AS OF DATE**: 20260327

**DATE AS OF CHANGE**: 20260327

**PERIOD START**: 20260430

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** FRANKLIN STRATEGIC SERIES
- **CENTRAL INDEX KEY:** 0000872625

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** FL
- **FISCAL YEAR END:** 0430

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-06243
- **FILM NUMBER:** 26806016

**BUSINESS ADDRESS:**
- **STREET 1:** ONE FRANKLIN PARKWAY
- **CITY:** SAN MATEO
- **STATE:** CA
- **ZIP:** 94403-1906
- **BUSINESS PHONE:** 650-570-3000

**MAIL ADDRESS:**
- **STREET 1:** ONE FRANKLIN PARKWAY
- **CITY:** SAN MATEO
- **STATE:** CA
- **ZIP:** 94403-1906

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** FRANKLIN CALIFORNIA 250 GROWTH FUND
- **DATE OF NAME CHANGE:** 19911216

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** FRANKLIN CALIFORNIA 250 GROWTH INDEX FUND
- **DATE OF NAME CHANGE:** 19910917

## Series and Classes Contracts Data

### FRANKLIN BIOTECHNOLOGY DISCOVERY FUND (Series ID: S000006882)

| Class ID   | Class Name    | Ticker Symbol   |
|:---|:---|:---|
| C000018631 | CLASS A       | FBDIX           |
| C000081539 | ADVISOR CLASS | FTDZX           |
| C000128862 | Class R6      | FRBRX           |
| C000141458 | Class C       | FBTDX           |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** Franklin Strategic Series

- **b. Investment Company Act file number:** 811-06243

- **c. CIK number of Registrant:** 0000872625

- **d. LEI of Registrant:** 549300NDWC0J6DXVSX36

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** One Franklin Parkway

  - **City:** San Mateo

  - **State:** CA

  - **Foreign country:** US

  - **Zip / Postal Code:** 94403-1906

  - **Telephone number:** 650-312-2000

**Item A.2. Information about the Series.**

- **a. Name of Series:** Franklin Biotechnology Discovery Fund

- **b. EDGAR series identifier (if any):** S000006882

- **c. LEI of Series:** 6N5133EDK315FXQQM036

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2026-04-30

- **b. Date as of which information is reported:** 2026-01-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $1054986143.42

**Total Liabilities:** $36375405.51

**Net Assets:** $1018610737.91

**Cash Not Reported:** $4336421.75

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000128862 | 10.90%               | -1.59%               | 0.21%                |
| Class ID C000018631 | 10.87%               | -1.61%               | 0.18%                |
| Class ID C000081539 | 10.89%               | -1.59%               | 0.20%                |
| Class ID C000141458 | 10.80%               | -1.67%               | 0.11%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $7224167.91              | $96499665.14                               |
| Month 2  | $-701570.96              | $-15889771.67                              |
| Month 3  | $7403252.36              | $-4795366.50                               |

### Schedule of Portfolio Investments

| Name                                                     | Title                                                    | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Apogee Therapeutics, Inc.                                | Apogee Therapeutics, Inc.                                | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     82737 | NS      | $5420100.87   | 0.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Ionis Pharmaceuticals, Inc.                              | Ionis Pharmaceuticals, Inc.                              | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |    205400 | NS      | $16980418.00  | 1.67%             |  |  |  | No            |                  1 | On Loan: No      |
| Solid Biosciences, Inc.                                  | Solid Biosciences, Inc.                                  | CUSIP: 83422E204<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    711882 | NS      | $4598757.72   | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| uniQure NV                                               | uniQure NV                                               | CUSIP: N/A<br>LEI: 724500RPCTZLFYJZ3S98       | Long             | EC               | CORP              | NL        |    270640 | NS      | $6148940.80   | 0.60%             |  |  |  | No            |                  1 | On Loan: No      |
| ORIC Pharmaceuticals, Inc.                               | ORIC Pharmaceuticals, Inc.                               | CUSIP: 68622P109<br>LEI: 54930033FJRNEYBW0L25 | Long             | EC               | CORP              | US        |    524519 | NS      | $5381564.94   | 0.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Tango Therapeutics, Inc.                                 | Tango Therapeutics, Inc.                                 | CUSIP: 87583X109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    491884 | NS      | $5710773.24   | 0.56%             |  |  |  | No            |                  1 | On Loan: —       |
| Jazz Pharmaceuticals plc                                 | Jazz Pharmaceuticals plc                                 | CUSIP: N/A<br>LEI: 635400GAUMJCLEZRRV50       | Long             | EC               | CORP              | IE        |    283073 | NS      | $46562677.77  | 4.57%             |  |  |  | No            |                  1 | On Loan: No      |
| Eli Lilly & Co.                                          | Eli Lilly & Co.                                          | CUSIP: 532457108<br>LEI: FRDRIPF3EKNDJ2CQJL29 | Long             | EC               | CORP              | US        |     14071 | NS      | $14593737.65  | 1.43%             |  |  |  | No            |                  1 | On Loan: No      |
| Amylyx Pharmaceuticals, Inc.                             | Amylyx Pharmaceuticals, Inc.                             | CUSIP: 03237H101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    439918 | NS      | $6286428.22   | 0.62%             |  |  |  | No            |                  1 | On Loan: No      |
| Mineralys Therapeutics, Inc.                             | Mineralys Therapeutics, Inc.                             | CUSIP: 603170101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    623239 | NS      | $19251852.71  | 1.89%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences, Inc.                             | Neurocrine Biosciences, Inc.                             | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |    135273 | NS      | $18405244.38  | 1.81%             |  |  |  | No            |                  1 | On Loan: No      |
| Achieve Life Sciences, Inc.                              | Achieve Life Sciences, Inc.                              | CUSIP: N/A<br>LEI: 549300V82ZKZDTAU0A46       | Long             |  | CORP              | US        |    698900 | NS      | $1148234.69   | 0.11%             |  |  |  | No            |                  3 | On Loan: No      |
| Insmed, Inc.                                             | Insmed, Inc.                                             | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |    188633 | NS      | $29590858.71  | 2.91%             |  |  |  | No            |                  1 | On Loan: No      |
| Dyne Therapeutics, Inc.                                  | Dyne Therapeutics, Inc.                                  | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    519232 | NS      | $9289060.48   | 0.91%             |  |  |  | No            |                  1 | On Loan: No      |
| Zealand Pharma A/S                                       | Zealand Pharma A/S, Class A                              | CUSIP: N/A<br>LEI: 549300ITBB1ULBL4CZ12       | Long             | EC               | CORP              | DK        |     69700 | NS      | $4661362.09   | 0.46%             |  |  |  | No            |                  2 | On Loan: No      |
| Soleno Therapeutics, Inc.                                | Soleno Therapeutics, Inc.                                | CUSIP: 834203309<br>LEI: 5493003LCY77N7FXK844 | Long             | EC               | CORP              | US        |    181503 | NS      | $6998755.68   | 0.69%             |  |  |  | No            |                  1 | On Loan: No      |
| Phathom Pharmaceuticals, Inc.                            | Phathom Pharmaceuticals, Inc.                            | CUSIP: 71722W107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    285271 | NS      | $3899654.57   | 0.38%             |  |  |  | No            |                  1 | On Loan: —       |
| Sartorius Stedim Biotech                                 | Sartorius Stedim Biotech                                 | CUSIP: N/A<br>LEI: 52990006IVXY7GCSSR39       | Long             | EC               | CORP              | FR        |     10100 | NS      | $2257027.67   | 0.22%             |  |  |  | No            |                  2 | On Loan: No      |
| Sartorius AG                                             | Sartorius AG                                             | CUSIP: N/A<br>LEI: 529900EQV2DY4FOAMU38       | Long             | EP               | CORP              | DE        |      9200 | NS      | $2571335.42   | 0.25%             |  |  |  | No            |                  2 | On Loan: No      |
| Benitec Biopharma, Inc.                                  | Benitec Biopharma, Inc.                                  | CUSIP: 08205P209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    995152 | NS      | $12120951.36  | 1.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Danish Krone                                             | Danish Krone                                             | CUSIP: N/A<br>LEI: N/A                        | Long             | STIV             |  | DK        |       740 | OU      | $117.45       | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Argenx SE                                                | Argenx SE                                                | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |     48962 | NS      | $41152561.00  | 4.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Aura Biosciences, Inc.                                   | Aura Biosciences, Inc.                                   | CUSIP: 05153U107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    765617 | NS      | $4287455.20   | 0.42%             |  |  |  | No            |                  1 | On Loan: —       |
| Olema Pharmaceuticals, Inc.                              | Olema Pharmaceuticals, Inc.                              | CUSIP: 68062P106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    560230 | NS      | $14409115.60  | 1.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Revolution Medicines, Inc.                               | Revolution Medicines, Inc.                               | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |    202430 | NS      | $19625588.50  | 1.93%             |  |  |  | No            |                  1 | On Loan: No      |
| Candid, Inc.                                             | Candid, Inc., Series B                                   | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |   1519609 | NS      | $2735296.20   | 0.27%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Contineum Therapeutics, Inc.                             | Contineum Therapeutics, Inc., Class A                    | CUSIP: 21217B100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    381063 | NS      | $5433958.38   | 0.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Engene Holdings, Inc.                                    | Engene Holdings, Inc.                                    | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | CA        |    272359 | NS      | $2595581.27   | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| BioAge Labs, Inc.                                        | BioAge Labs, Inc.                                        | CUSIP: 09077V100<br>LEI: 529900NG0C40250Z7875 | Long             | EC               | CORP              | US        |     90709 | NS      | $1722563.91   | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Ideaya Biosciences, Inc.                                 | Ideaya Biosciences, Inc.                                 | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |     81852 | NS      | $2634815.88   | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Dianthus Therapeutics, Inc.                              | Dianthus Therapeutics, Inc.                              | CUSIP: 252828108<br>LEI: 549300Z3N6ODPCOFC890 | Long             | EC               | CORP              | US        |    203063 | NS      | $10841533.57  | 1.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Praxis Precision Medicines, Inc.                         | Praxis Precision Medicines, Inc.                         | CUSIP: 74006W207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    104696 | NS      | $32874544.00  | 3.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytokinetics, Inc.                                       | Cytokinetics, Inc.                                       | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |     53272 | NS      | $3366257.68   | 0.33%             |  |  |  | No            |                  1 | On Loan: No      |
| Satellos Bioscience, Inc.                                | Satellos Bioscience, Inc.                                | CUSIP: 80401L803<br>LEI: 529900EN243BZ5QC9N39 | Long             | EC               | CORP              | CA        |   1161960 | NS      | $1100106.55   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Palisade Bio, Inc.                                       | Palisade Bio, Inc.                                       | CUSIP: 696389154<br>LEI: 549300W6LIDX3I5XXT34 | Long             |  | CORP              | US        |   1447549 | NS      | $2156703.26   | 0.21%             |  |  |  | No            |                  3 | On Loan: No      |
| Centessa Pharmaceuticals plc                             | Centessa Pharmaceuticals plc                             | CUSIP: 152309100<br>LEI: 213800GIDAARDSKOI827 | Long             | EC               | CORP              | GB        |    424429 | NS      | $10428220.53  | 1.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Lycia LLC                                                | Lycia LLC, Series C                                      | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | JP        |    859370 | NS      | $2814331.05   | 0.28%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Xenon Pharmaceuticals, Inc.                              | Xenon Pharmaceuticals, Inc.                              | CUSIP: 98420N105<br>LEI: 549300XV44Q9Z1MIPQ03 | Long             | EC               | CORP              | CA        |    123767 | NS      | $5075684.67   | 0.50%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC Therapeutics, Inc.                                   | PTC Therapeutics, Inc.                                   | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |    369527 | NS      | $27910374.31  | 2.74%             |  |  |  | No            |                  1 | On Loan: No      |
| Ultragenyx Pharmaceutical, Inc.                          | Ultragenyx Pharmaceutical, Inc.                          | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |    108067 | NS      | $2601172.69   | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Bicara Therapeutics, Inc.                                | Bicara Therapeutics, Inc.                                | CUSIP: 055477103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    387402 | NS      | $6508353.60   | 0.64%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvalent, Inc.                                           | Nuvalent, Inc., Class A                                  | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     75535 | NS      | $7771796.15   | 0.76%             |  |  |  | No            |                  1 | On Loan: No      |
| Mirum Pharmaceuticals, Inc.                              | Mirum Pharmaceuticals, Inc.                              | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |    215190 | NS      | $22211911.80  | 2.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Vicore Pharma Holding AB                                 | Vicore Pharma Holding AB                                 | CUSIP: N/A<br>LEI: 549300KTNBPTZLF01130       | Long             | EC               | CORP              | SE        |   1307598 | NS      | $1638259.18   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| AstraZeneca plc                                          | AstraZeneca plc                                          | CUSIP: 046353108<br>LEI: PY6ZZQWO2IZFZC3IOL08 | Long             | EC               | CORP              | GB        |    205062 | NS      | $19023601.74  | 1.87%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcutis Biotherapeutics, Inc.                            | Arcutis Biotherapeutics, Inc.                            | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    505651 | NS      | $12828365.87  | 1.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvation Bio, Inc.                                       | Nuvation Bio, Inc.                                       | CUSIP: 67080N119<br>LEI: N/A                  | Long             |  | CORP              | US        |    115266 | NS      | $4380.11      | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Abivax SA                                                | Abivax SA                                                | CUSIP: 00370M103<br>LEI: 969500D8TMNB184OJU95 | Long             | EC               | CORP              | FR        |    164591 | NS      | $18294289.65  | 1.80%             |  |  |  | No            |                  1 | On Loan: No      |
| CG oncology, Inc.                                        | CG oncology, Inc.                                        | CUSIP: 156944100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    221481 | NS      | $11528086.05  | 1.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Syndax Pharmaceuticals, Inc.                             | Syndax Pharmaceuticals, Inc.                             | CUSIP: 87164F105<br>LEI: 529900OF94TRHKZVBS87 | Long             | EC               | CORP              | US        |    579788 | NS      | $11775494.28  | 1.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals, Inc.                            | Alnylam Pharmaceuticals, Inc.                            | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |     66908 | NS      | $22618918.48  | 2.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Context Therapeutics, Inc.                               | Context Therapeutics, Inc.                               | CUSIP: 21077P108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1479200 | NS      | $3860712.00   | 0.38%             |  |  |  | No            |                  1 | On Loan: No      |
| Ascendis Pharma A/S                                      | Ascendis Pharma A/S                                      | CUSIP: 04351P101<br>LEI: 549300B66JN3W3J8GH73 | Long             | EC               | CORP              | DK        |    129742 | NS      | $29334666.20  | 2.88%             |  |  |  | No            |                  1 | On Loan: No      |
| Oruka Therapeutics, Inc.                                 | Oruka Therapeutics, Inc.                                 | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |     86030 | NS      | $2944806.90   | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Oruka Therapeutics, Inc.                                 | Oruka Therapeutics, Inc.                                 | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |    249964 | NS      | $8556267.72   | 0.84%             |  |  |  | No            |                  1 | On Loan: No      |
| Assembly Biosciences, Inc.                               | Assembly Biosciences, Inc.                               | CUSIP: 045396207<br>LEI: 5299007Y1X8RBDFT8C40 | Long             | EC               | CORP              | US        |     29620 | NS      | $763455.50    | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Newamsterdam Pharma Co. NV                               | Newamsterdam Pharma Co. NV                               | CUSIP: N/A<br>LEI: 984500B6549TF6E14D36       | Long             | EC               | CORP              | NL        |    187726 | NS      | $5842033.12   | 0.57%             |  |  |  | No            |                  1 | On Loan: No      |
| Immix Biopharma, Inc.                                    | Immix Biopharma, Inc.                                    | CUSIP: 45258H106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    357034 | NS      | $2081508.22   | 0.20%             |  |  |  | No            |                  1 | On Loan: —       |
| Alto Neuroscience, Inc.                                  | Alto Neuroscience, Inc.                                  | CUSIP: 02157Q109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    240205 | NS      | $3718373.40   | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Structure Therapeutics, Inc.                             | Structure Therapeutics, Inc.                             | CUSIP: 86366E106<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |     34633 | NS      | $3063288.85   | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals, Inc.                             | Vertex Pharmaceuticals, Inc.                             | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |    102150 | NS      | $48000285.00  | 4.71%             |  |  |  | No            |                  1 | On Loan: No      |
| ARS Pharmaceuticals, Inc.                                | ARS Pharmaceuticals, Inc.                                | CUSIP: 82835W108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    901810 | NS      | $9009081.90   | 0.88%             |  |  |  | No            |                  1 | On Loan: —       |
| LENZ Therapeutics, Inc.                                  | LENZ Therapeutics, Inc.                                  | CUSIP: 52635N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    312267 | NS      | $4940063.94   | 0.48%             |  |  |  | No            |                  1 | On Loan: —       |
| Artiva Biotherapeutics, Inc.                             | Artiva Biotherapeutics, Inc.                             | CUSIP: 04317A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    192871 | NS      | $750268.19    | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| GRAIL, Inc.                                              | GRAIL, Inc.                                              | CUSIP: 384747101<br>LEI: 2549009XSNESW3VE8024 | Long             | EC               | CORP              | US        |     46433 | NS      | $4542076.06   | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Assembly Biosciences, Inc.                               | Assembly Biosciences, Inc., Series A                     | CUSIP: N/A<br>LEI: 5299007Y1X8RBDFT8C40       | Long             | EC               | CORP              | US        |     44450 | NS      | $487256.94    | 0.05%             |  |  |  | No            |                  3 | On Loan: No      |
| Carmot Therapeutics, Inc.                                | Carmot Therapeutics, Inc.                                | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |     83100 | NS      | $531572.50    | 0.05%             |  |  |  | No            |                  3 | On Loan: No      |
| Acumen Pharmaceuticals, Inc.                             | Acumen Pharmaceuticals, Inc.                             | CUSIP: 00509G209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    826400 | NS      | $2148640.00   | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Franklin Institutional U.S. Government Money Market Fund | Franklin Institutional U.S. Government Money Market Fund | CUSIP: 8611239C3<br>LEI: 549300M4TP89K77LG374 | Long             | STIV             | RF                | US        |  35318834 | NS      | $35318834.25  | 3.47%             |  |  |  | No            |                  1 | On Loan: No      |
| EyePoint, Inc.                                           | EyePoint, Inc.                                           | CUSIP: 30233G209<br>LEI: 549300QE1RU34T50MR69 | Long             | EC               | CORP              | US        |   1269215 | NS      | $17159786.80  | 1.68%             |  |  |  | No            |                  1 | On Loan: No      |
| Bridgebio Pharma, Inc.                                   | Bridgebio Pharma, Inc.                                   | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |    207858 | NS      | $16061187.66  | 1.58%             |  |  |  | No            |                  1 | On Loan: No      |
| Spyre Therapeutics, Inc.                                 | Spyre Therapeutics, Inc.                                 | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |    220000 | NS      | $7035600.00   | 0.69%             |  |  |  | No            |                  1 | On Loan: No      |
| Verastem, Inc.                                           | Verastem, Inc.                                           | CUSIP: 92337C203<br>LEI: 549300IY0EFBIU8NQC81 | Long             | EC               | CORP              | US        |    401744 | NS      | $2450638.40   | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Achieve Life Sciences, Inc.                              | Achieve Life Sciences, Inc.                              | CUSIP: 004468500<br>LEI: 549300V82ZKZDTAU0A46 | Long             | EC               | CORP              | US        |   1575682 | NS      | $6586350.76   | 0.65%             |  |  |  | No            |                  1 | On Loan: —       |
| BeOne Medicines Ltd.                                     | BeOne Medicines Ltd.                                     | CUSIP: 07725L102<br>LEI: 549300JFUK6FRD5MH739 | Long             | EC               | CORP              | CH        |     14276 | NS      | $4859264.88   | 0.48%             |  |  |  | No            |                  1 | On Loan: No      |
| Centessa Pharmaceuticals plc                             | Centessa Pharmaceuticals plc                             | CUSIP: 152309100<br>LEI: 213800GIDAARDSKOI827 | Long             | EC               | CORP              | GB        |    189736 | NS      | $4661813.52   | 0.46%             |  |  |  | No            |                  1 | On Loan: No      |
| Amgen, Inc.                                              | Amgen, Inc.                                              | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |    143458 | NS      | $49045421.04  | 4.81%             |  |  |  | No            |                  1 | On Loan: No      |
| Palisade Bio, Inc.                                       | Palisade Bio, Inc.                                       | CUSIP: 696389402<br>LEI: 549300W6LIDX3I5XXT34 | Long             | EC               | CORP              | US        |   2119910 | NS      | $3158665.90   | 0.31%             |  |  |  | No            |                  1 | On Loan: —       |
| Inventiva SACA                                           | Inventiva SACA                                           | CUSIP: 46124U107<br>LEI: 969500I9Y690B3FZW590 | Long             | EC               | CORP              | FR        |    908000 | NS      | $5593280.00   | 0.55%             |  |  |  | No            |                  1 | On Loan: —       |
| IN8bio, Inc.                                             | IN8bio, Inc.                                             | CUSIP: 45674E208<br>LEI: 549300H68IVCRKSGSL94 | Long             | EC               | CORP              | US        |    332083 | NS      | $654203.51    | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Spyre Therapeutics, Inc.                                 | Spyre Therapeutics, Inc.                                 | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |    176281 | NS      | $5637466.38   | 0.55%             |  |  |  | No            |                  1 | On Loan: No      |
| Assembly Biosciences, Inc.                               | Assembly Biosciences, Inc., Series B                     | CUSIP: N/A<br>LEI: 5299007Y1X8RBDFT8C40       | Long             | EC               | CORP              | US        |     44450 | NS      | $30819.41     | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| IN8bio, Inc.                                             | IN8bio, Inc., Series C                                   | CUSIP: N/A<br>LEI: 549300H68IVCRKSGSL94       | Long             |  | CORP              | US        |     69673 | NS      | $33676.58     | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Regeneron Pharmaceuticals, Inc.                          | Regeneron Pharmaceuticals, Inc.                          | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |     61019 | NS      | $45242537.55  | 4.44%             |  |  |  | No            |                  1 | On Loan: No      |
| Adicet Bio, Inc.                                         | Adicet Bio, Inc.                                         | CUSIP: 007002207<br>LEI: 549300VRD2QO80WBOP18 | Long             | EC               | CORP              | US        |    225186 | NS      | $1799236.14   | 0.18%             |  |  |  | No            |                  1 | On Loan: —       |
| Gilead Sciences, Inc.                                    | Gilead Sciences, Inc.                                    | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |    443663 | NS      | $62977962.85  | 6.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Thermo Fisher Scientific, Inc.                           | Thermo Fisher Scientific, Inc.                           | CUSIP: 883556102<br>LEI: HCHV7422L5HDJZCRFL38 | Long             | EC               | CORP              | US        |      8579 | NS      | $4963895.19   | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Guardant Health, Inc.                                    | Guardant Health, Inc.                                    | CUSIP: 40131M109<br>LEI: 254900M8C3E5VC8BR186 | Long             | EC               | CORP              | US        |    248985 | NS      | $28394249.40  | 2.79%             |  |  |  | No            |                  1 | On Loan: No      |
| Structure Therapeutics, Inc.                             | Structure Therapeutics, Inc.                             | CUSIP: 86366E106<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |    192930 | NS      | $17064658.50  | 1.68%             |  |  |  | No            |                  1 | On Loan: No      |
| Franklin Institutional U.S. Government Money Market Fund | Franklin Institutional U.S. Government Money Market Fund | CUSIP: 457756500<br>LEI: 549300M4TP89K77LG374 | Long             | STIV             | RF                | US        |   8793093 | NS      | $8793092.76   | 0.86%             |  |  |  | No            |                  1 | On Loan: No      |
| Sanofi SA                                                | Sanofi SA, Escrow Account                                | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | CO        |   2333755 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Cardiff Oncology, Inc.                                   | Cardiff Oncology, Inc.                                   | CUSIP: 14147L108<br>LEI: 549300AHOLZBHHYFWP04 | Long             | EC               | CORP              | US        |    438961 | NS      | $768181.75    | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Contineum Therapeutics, Inc.                             | Contineum Therapeutics, Inc., Class A                    | CUSIP: 21217B100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    295058 | NS      | $4207527.08   | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Sionna Therapeutics, Inc.                                | Sionna Therapeutics, Inc.                                | CUSIP: 829401108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     60891 | NS      | $2573253.66   | 0.25%             |  |  |  | No            |                  1 | On Loan: —       |
| Benitec Biopharma, Inc.                                  | Benitec Biopharma, Inc.                                  | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |    310881 | NS      | $3786499.49   | 0.37%             |  |  |  | No            |                  3 | On Loan: No      |
| Alto Neuroscience, Inc.                                  | Alto Neuroscience, Inc.                                  | CUSIP: 02157Q109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    165070 | NS      | $2555283.60   | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Engene Holdings, Inc.                                    | Engene Holdings, Inc.                                    | CUSIP: 29286M105<br>LEI: N/A                  | Long             | EC               | CORP              | CA        |    214220 | NS      | $2041516.60   | 0.20%             |  |  |  | No            |                  1 | On Loan: —       |
| Terns Pharmaceuticals, Inc.                              | Terns Pharmaceuticals, Inc.                              | CUSIP: 880881107<br>LEI: 254900S1ZDQMF4MYP709 | Long             | EC               | CORP              | US        |    770542 | NS      | $26660753.20  | 2.62%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2026-03-02

**Name of Applicant:** Franklin Strategic Series

**Signature:** Monica Krogh

**Name of Signer:** Monica Krogh

**Title:** Assistant Treasurer