# EDGAR Filing Document

**Accession Number:** 0001757499
**File Stem:** 0001493152-26-006671
**Filing Date:** 2026-2
**Character Count:** 2709
**Document Hash:** 5edfba94132a3d74f8d64803f0b8df99
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001493152-26-006671.hdr.sgml**: 20260319

**ACCESSION NUMBER**: 0001493152-26-006671

**CONFORMED SUBMISSION TYPE**: CORRESP

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20260213

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Shuttle Pharmaceuticals Holdings, Inc.
- **CENTRAL INDEX KEY:** 0001757499
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** CORRESP

**BUSINESS ADDRESS:**
- **STREET 1:** 401 PROFESSIONAL DRIVE
- **STREET 2:** SUITE 260
- **CITY:** GAITHERSBURG
- **STATE:** MD
- **ZIP:** 20879
- **BUSINESS PHONE:** (240) 403-4212

**MAIL ADDRESS:**
- **STREET 1:** 401 PROFESSIONAL DRIVE
- **STREET 2:** SUITE 260
- **CITY:** GAITHERSBURG
- **STATE:** MD
- **ZIP:** 20879

**E.F. Hutton & Co.**

**745 Fifth Avenue, 34th Floor & PH**

**New York, NY 10151**

February 13, 2026

<u>VIA EDGAR</u>

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

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| | |
|:---|:---|
| **Re:** | **Shuttle Pharmaceuticals Holdings, Inc.** |
|  | **Registration Statement on Form S-1** |
|  | **File No. 333-293363** |

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REQUEST FOR ACCELERATION OF EFFECTIVENESS

Requested Date: Tuesday, February 17, 2026 <br> Requested Time: 4:30 p.m., Eastern Time

Ladies and Gentlemen:

Pursuant to Rule 461 of the General Rules and Regulations under the Securities Act of 1933, as amended (the "Securities Act"), we, the undersigned, as the sole placement agent for the proposed public offering on a best-efforts basis of securities of Shuttle Pharmaceuticals Holdings, Inc. (the "Company"), hereby join the Company's request that the effective date of the above-referenced Registration Statement on Form S-1, as amended, be accelerated so that it will be declared effective at 4:30 p.m., Eastern Time, on Tuesday, February 17, 2026, or as soon thereafter as possible.

Pursuant to Rule 460 under the Securities Act, please be advised that we will distribute as many copies of the proposed form of preliminary prospectus as it appears to be reasonable to secure adequate distribution of the preliminary prospectus.

The undersigned confirms that it has complied with and will continue to comply with the requirements of Rule 15c2-8 promulgated under the Securities Exchange Act of 1934, as amended.

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| | |
|:---|:---|
| Very truly yours, | Very truly yours, |
| E.F. HUTTON & CO. | E.F. HUTTON & CO. |
| By: | */s/ Duncan B. Swanston* |
| Name: | Duncan B. Swanston |
| Title: | Supervisory Principal |

---