# EDGAR Filing Document

**Accession Number:** 0001388325
**File Stem:** 0000950123-23-002359
**Filing Date:** 2023-2
**Character Count:** 8589
**Document Hash:** d8cc99fd2dd22e4957b445f2813bd69c
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000950123-23-002359.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0000950123-23-002359

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**EFFECTIVENESS DATE**: 20230214

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Novo Holdings A/S
- **CENTRAL INDEX KEY:** 0001388325
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** G7
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-16231
- **FILM NUMBER:** 23624321

**BUSINESS ADDRESS:**
- **STREET 1:** TUBORG HAVNEVEJ 19
- **CITY:** HELLERUP
- **STATE:** G7
- **ZIP:** 2900
- **BUSINESS PHONE:** 45 8824 8824

**MAIL ADDRESS:**
- **STREET 1:** TUBORG HAVNEVEJ 19
- **CITY:** HELLERUP
- **STATE:** G7
- **ZIP:** 2900

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Novo A/S
- **DATE OF NAME CHANGE:** 20070130

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2022

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** Novo Holdings A/S<br>**Address:** TUBORG HAVNEVEJ 19<br>HELLERUP, G7 2900

**Form 13F File Number:** 028-16231

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Barbara Fiorini Due<br>**Title:** General Counsel<br>**Phone:** 45 3527 6500

**Signature, Place, and Date of Signing:**

/s/ Barbara Fiorini Due  Hellerup, G7  02-14-2023<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 48

**Form 13F Information Table Value Total:** $1601649040

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| ABCELLERA BIOLOGICS INC | COM | 00288U106 |  | 11415649 | 1126915 | SH |  | SOLE |  | 1126915 | 0 | 0 |
| ALIBABA GROUP HLDG LTD | SPONSORED ADS | 01609W102 |  | 44117850 | 500827 | SH |  | SOLE |  | 500827 | 0 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 |  | 26616800 | 112000 | SH |  | SOLE |  | 100000 | 0 | 0 |
| AMICUS THERAPEUTICS INC | COM | 03152W109 |  | 25590939 | 2095900 | SH |  | SOLE |  | 2100000 | 0 | 0 |
| ARCELLX INC. | COMMON STOCK | 03940C100 |  | 45974940 | 1484020 | SH |  | SOLE |  | 3191878 | 0 | 0 |
| APPLE INC | COM | 037833100 |  | 47957683 | 369104 | SH |  | SOLE |  | 461379 | 0 | 0 |
| ASML HOLDING N V | N Y REGISTRY SHS | N07059210 |  | 123907128 | 226770 | SH |  | SOLE |  | 226770 | 0 | 0 |
| BELLUS HEALTH INC. | COM NEW | 07987C204 |  | 13958250 | 1698084 | SH |  | SOLE |  | 1698084 | 0 | 0 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 |  | 32878773 | 317700 | SH |  | SOLE |  | 317500 | 0 | 0 |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 |  | 16209700 | 370000 | SH |  | SOLE |  | 316674 | 0 | 0 |
| BOSTON SCIENTIFIC CORP | COM | 101137107 |  | 62607058 | 1353081 | SH |  | SOLE |  | 1762942 | 0 | 0 |
| BROOKFIELD ASSET MGMT INC | CL A LTD VT SH | 112585104 |  | 71928156 | 2508830 | SH |  | SOLE |  | 2508830 | 0 | 0 |
| CABLE ONE INC | COM | 12685J105 |  | 66988162 | 94103 | SH |  | SOLE |  | 80023 | 0 | 0 |
| CATALENT INC | COM | 148806102 |  | 73495839 | 1632878 | SH |  | SOLE |  | 1632878 | 0 | 0 |
| CORCEPT THERAPEUTICS INC | COM | 218352102 |  | 68602468 | 3377768 | SH |  | SOLE |  | 3327768 | 0 | 0 |
| CRINETICS PHARMACEUTICALS IN | COM | 22663K107 |  | 13488143 | 737057 | SH |  | SOLE |  | 631627 | 0 | 0 |
| CYTEIR THERAPEUTICS INC | COM | 23284P103 |  | 6501681 | 3940413 | SH |  | SOLE |  | 3940413 | 0 | 0 |
| DICE THERAPEUTICS INC. | COM | 23345J104 |  | 14508000 | 465000 | SH |  | SOLE |  | 465000 | 0 | 0 |
| DISC MEDICINE INC. | COM | 254604101 |  | 46557962 | 2340772 | SH |  | SOLE |  | 2340772 | 0 | 0 |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 |  | 54281025 | 6071703 | SH |  | SOLE |  | 6071703 | 0 | 0 |
| GALECTO INC | COM | 36322Q107 |  | 2872460 | 2497791 | SH |  | SOLE |  | 2497791 | 0 | 0 |
| GALERA THERAPEUTICS INC | COM | 36338D108 |  | 3663941 | 2459021 | SH |  | SOLE |  | 2459021 | 0 | 0 |
| INARI MED INC | COM | 45332Y109 |  | 15305248 | 240800 | SH |  | SOLE |  | 213200 | 0 | 0 |
| INSMED INC | COM PAR $.01 | 457669307 |  | 16783200 | 840000 | SH |  | SOLE |  | 770000 | 0 | 0 |
| INSPIRE MED SYS INC | COM | 457730109 |  | 15945012 | 63304 | SH |  | SOLE |  | 60900 | 0 | 0 |
| IO BIOTECH INC | COM | 449778109 |  | 7539244 | 3277932 | SH |  | SOLE |  | 3277932 | 0 | 0 |
| KEZAR LIFE SCIENCES INC | COM | 49372L100 |  | 8272000 | 1175000 | SH |  | SOLE |  | 598377 | 0 | 0 |
| KINNATE BIOPHARMA INC | COM | 49705R105 |  | 4975813 | 815707 | SH |  | SOLE |  | 815707 | 0 | 0 |
| LAVA THERAPEUTICS NV | SHS | N51517105 |  | 11645592 | 3327312 | SH |  | SOLE |  | 3327312 | 0 | 0 |
| MARQETA INC | CLASS A COM | 57142B104 |  | 2697919 | 441558 | SH |  | SOLE |  | 441558 | 0 | 0 |
| MIRUM PHARMACEUTICALS INC | COM | 604749101 |  | 32841764 | 1684193 | SH |  | SOLE |  | 1684193 | 0 | 0 |
| PHARVARIS N V | COM | N69605108 |  | 13357204 | 1187307 | SH |  | SOLE |  | 610000 | 0 | 0 |
| PULMONX CORP | COM | 745848101 |  | 4303979 | 510555 | SH |  | SOLE |  | 510555 | 0 | 0 |
| RALLYBIO CORP | COM | 75120L100 |  | 15084766 | 2296007 | SH |  | SOLE |  | 630921 | 0 | 0 |
| RENEO PHARMACEUTICALS INC | COM | 75974E103 |  | 7992778 | 3430377 | SH |  | SOLE |  | 3430377 | 0 | 0 |
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 |  | 16634500 | 850000 | SH |  | SOLE |  | 632822 | 0 | 0 |
| SALESFORCE.COM INC. | COM | 79466L302 |  | 76703315 | 578500 | SH |  | SOLE |  | 578500 | 0 | 0 |
| SEAGEN INC. | COM | 81181C104 |  | 26987100 | 210000 | SH |  | SOLE |  | 75000 | 0 | 0 |
| SILK RD MED INC | COM | 82710M100 |  | 14560756 | 275511 | SH |  | SOLE |  | 275511 | 0 | 0 |
| STERIS PLC | SHS USD | G8473T100 |  | 86377112 | 467687 | SH |  | SOLE |  | 467687 | 0 | 0 |
| STRYKER CORPORATION | COM | 863667101 |  | 194844105 | 796941 | SH |  | SOLE |  | 796941 | 0 | 0 |
| SPERO THERAPEUTICS INC | COM | 84833T103 |  | 811200 | 468902 | SH |  | SOLE |  | 468902 | 0 | 0 |
| SPRUCE BIOSCIENCES INC | COM | 85209E109 |  | 4952227 | 4514336 | SH |  | SOLE |  | 4514336 | 0 | 0 |
| TAIWAN SEMICONDUCTOR MFG LTD | SPONSORED ADS | 874039100 |  | 52946002 | 710780 | SH |  | SOLE |  | 710780 | 0 | 0 |
| TREACE MED CONCEPTS INC | COM | 89455T109 |  | 14651918 | 637317 | SH |  | SOLE |  | 588308 | 0 | 0 |
| VAXCYTE INC | COM | 92243G108 |  | 34763750 | 725000 | SH |  | SOLE |  | 823705 | 0 | 0 |
| VECTIVBIO HLDG AG | ORD SHS | H9060V101 |  | 28919931 | 3339484 | SH |  | SOLE |  | 3339484 | 0 | 0 |
| VERVE THERAPEUTICS INC | COM | 92539P101 |  | 17629998 | 911111 | SH |  | SOLE |  | 911111 | 0 | 0 |

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