# EDGAR Filing Document

**Accession Number:** 0001637715
**File Stem:** 0001213900-25-076638
**Filing Date:** 2025-8
**Character Count:** 17452
**Document Hash:** 5a6ce666a105dab804295c656735b54c
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001213900-25-076638.hdr.sgml**: 20250814

**ACCESSION NUMBER**: 0001213900-25-076638

**CONFORMED SUBMISSION TYPE**: SCHEDULE 13G

**PUBLIC DOCUMENT COUNT**: 2

**FILED AS OF DATE**: 20250814

**DATE AS OF CHANGE**: 20250814

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** OnKure Therapeutics, Inc.
- **CENTRAL INDEX KEY:** 0001637715
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 472309515
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SCHEDULE 13G
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-92480
- **FILM NUMBER:** 251218714

**BUSINESS ADDRESS:**
- **STREET 1:** 6707 WINCHESTER CIRCLE, SUITE 400
- **CITY:** BOULDER
- **STATE:** CO
- **ZIP:** 80301
- **BUSINESS PHONE:** (720) 307-2892

**MAIL ADDRESS:**
- **STREET 1:** 6707 WINCHESTER CIRCLE, SUITE 400
- **CITY:** BOULDER
- **STATE:** CO
- **ZIP:** 80301

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Reneo Pharmaceuticals, Inc.
- **DATE OF NAME CHANGE:** 20150325
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** CANTOR FITZGERALD & CO.
- **CENTRAL INDEX KEY:** 0000017018

**ORGANIZATION NAME:**
- **EIN:** 133680184
- **STATE OF INCORPORATION:** NY
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SCHEDULE 13G

**BUSINESS ADDRESS:**
- **STREET 1:** 110 EAST 59TH STREET, 4TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10022
- **BUSINESS PHONE:** 212-829-4828

**MAIL ADDRESS:**
- **STREET 1:** 110 EAST 59TH STREET, 4TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10022

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** CANTOR FITZGERALD & CO                                  /BD
- **DATE OF NAME CHANGE:** 20020318

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** CANTOR FITZGERALD & CO                             /BD
- **DATE OF NAME CHANGE:** 19991006

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** CANTOR FITZGERALD & CO INC                              /BD
- **DATE OF NAME CHANGE:** 19921029

## Exhibit 99.1

**Exhibit 99.1**

**JOINT FILING AGREEMENT**

Each of the undersigned hereby acknowledges and agrees, in compliance with the provisions of Rule 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, as amended, that the Schedule 13G to which this Agreement is attached as an Exhibit, and any amendments thereto, will be filed with the Securities and Exchange Commission jointly on behalf of the undersigned. This Agreement may be executed in one or more counterparts.

Date: August 14, 2025

---

| | | |
|:---|:---|:---|
| CANTOR FITZGERALD & CO. | CANTOR FITZGERALD & CO. | CANTOR FITZGERALD & CO. |
| By: | /s/ Pascal Bandelier | /s/ Pascal Bandelier |
|  | Name: | Pascal Bandelier |
|  | Title: | Co-Chief Executive Officer |
| CANTOR FITZGERALD SECURITIES | CANTOR FITZGERALD SECURITIES | CANTOR FITZGERALD SECURITIES |
| By: | /s/ Pascal Bandelier | /s/ Pascal Bandelier |
|  | Name: | Pascal Bandelier |
|  | Title: | Co-Chief Executive Officer |
| CANTOR FITZGERALD, L.P. | CANTOR FITZGERALD, L.P. | CANTOR FITZGERALD, L.P. |
| By: | /s/ Brandon Lutnick | /s/ Brandon Lutnick |
|  | Name: | Brandon Lutnick |
|  | Title: | Chairman & Chief Executive Officer |
| CF GROUP MANAGEMENT, INC. | CF GROUP MANAGEMENT, INC. | CF GROUP MANAGEMENT, INC. |
| By: | /s/ Brandon Lutnick | /s/ Brandon Lutnick |
|  | Name: | Brandon Lutnick |
|  | Title: | Chairman & Chief Executive Officer |

---

[Schedule 13G – OnKure Therapeutics, Inc. – Joint Filing Agreement – August 2025]

### UNITED STATES SECURITIES AND EXCHANGE COMMISSION
**Washington, D.C. 20549**

## SCHEDULE 13G

### Under the Securities Exchange Act of 1934

**Issuer:** OnKure Therapeutics Inc.

**Title of Class of Securities:** Class A Common Stock, par value $0.0001 per share

**CUSIP Number:** 68277Q105

**Date of Event Which Requires Filing of this Statement:** 06/30/2025

**Check the appropriate box to designate the rule pursuant to which this Schedule is filed:**

- [ ] Rule 13d-1(b)

- [x] Rule 13d-1(c)

- [ ] Rule 13d-1(d)

---

| 1. | Names of Reporting Persons<br>Cantor Fitzgerald Securities | Names of Reporting Persons<br>Cantor Fitzgerald Securities |
|:---|:---|:---|:---|
| 2. | Check the Appropriate Box if a Member of a Group (See Instructions)<br>(a) [ ] (b) [ ] | Check the Appropriate Box if a Member of a Group (See Instructions)<br>(a) [ ] (b) [ ] |
| 3. | SEC Use Only | SEC Use Only |
| 4. | Citizenship or Place of Organization<br>NY | Citizenship or Place of Organization<br>NY |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 5. | Sole Voting Power<br>0.00 |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 6. | Shared Voting Power<br>669539.00 |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 7. | Sole Dispositive Power<br>0.00 |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 8. | Shared Dispositive Power<br>669539.00 |
| 9. | Aggregate Amount Beneficially Owned by Each Reporting Person<br>669539.00 | Aggregate Amount Beneficially Owned by Each Reporting Person<br>669539.00 |
| 10. | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) [ ] | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) [ ] |
| 11. | Percent of Class Represented by Amount in Row (9)<br>5.2% | Percent of Class Represented by Amount in Row (9)<br>5.2% |
| 12. | Type of Reporting Person (See Instructions)<br>PN | Type of Reporting Person (See Instructions)<br>PN |

**Comment for Type of Reporting Person:** * N/A

---

| 1. | Names of Reporting Persons<br>Cantor Fitzgerald & Co. | Names of Reporting Persons<br>Cantor Fitzgerald & Co. |
|:---|:---|:---|:---|
| 2. | Check the Appropriate Box if a Member of a Group (See Instructions)<br>(a) [ ] (b) [ ] | Check the Appropriate Box if a Member of a Group (See Instructions)<br>(a) [ ] (b) [ ] |
| 3. | SEC Use Only | SEC Use Only |
| 4. | Citizenship or Place of Organization<br>NY | Citizenship or Place of Organization<br>NY |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 5. | Sole Voting Power<br>0.00 |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 6. | Shared Voting Power<br>669539.00 |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 7. | Sole Dispositive Power<br>0.00 |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 8. | Shared Dispositive Power<br>669539.00 |
| 9. | Aggregate Amount Beneficially Owned by Each Reporting Person<br>669539.00 | Aggregate Amount Beneficially Owned by Each Reporting Person<br>669539.00 |
| 10. | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) [ ] | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) [ ] |
| 11. | Percent of Class Represented by Amount in Row (9)<br>5.2% | Percent of Class Represented by Amount in Row (9)<br>5.2% |
| 12. | Type of Reporting Person (See Instructions)<br>PN | Type of Reporting Person (See Instructions)<br>PN |

**Comment for Type of Reporting Person:** * N/A

---

| 1. | Names of Reporting Persons<br>Cantor Fitzgerald, L.P. | Names of Reporting Persons<br>Cantor Fitzgerald, L.P. |
|:---|:---|:---|:---|
| 2. | Check the Appropriate Box if a Member of a Group (See Instructions)<br>(a) [ ] (b) [ ] | Check the Appropriate Box if a Member of a Group (See Instructions)<br>(a) [ ] (b) [ ] |
| 3. | SEC Use Only | SEC Use Only |
| 4. | Citizenship or Place of Organization<br>DE | Citizenship or Place of Organization<br>DE |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 5. | Sole Voting Power<br>0.00 |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 6. | Shared Voting Power<br>669539.00 |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 7. | Sole Dispositive Power<br>0.00 |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 8. | Shared Dispositive Power<br>669539.00 |
| 9. | Aggregate Amount Beneficially Owned by Each Reporting Person<br>669539.00 | Aggregate Amount Beneficially Owned by Each Reporting Person<br>669539.00 |
| 10. | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) [ ] | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) [ ] |
| 11. | Percent of Class Represented by Amount in Row (9)<br>5.2% | Percent of Class Represented by Amount in Row (9)<br>5.2% |
| 12. | Type of Reporting Person (See Instructions)<br>PN | Type of Reporting Person (See Instructions)<br>PN |

**Comment for Type of Reporting Person:** * N/A

---

| 1. | Names of Reporting Persons<br>CF Group Management, Inc. | Names of Reporting Persons<br>CF Group Management, Inc. |
|:---|:---|:---|:---|
| 2. | Check the Appropriate Box if a Member of a Group (See Instructions)<br>(a) [ ] (b) [ ] | Check the Appropriate Box if a Member of a Group (See Instructions)<br>(a) [ ] (b) [ ] |
| 3. | SEC Use Only | SEC Use Only |
| 4. | Citizenship or Place of Organization<br>NY | Citizenship or Place of Organization<br>NY |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 5. | Sole Voting Power<br>0.00 |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 6. | Shared Voting Power<br>669539.00 |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 7. | Sole Dispositive Power<br>0.00 |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 8. | Shared Dispositive Power<br>669539.00 |
| 9. | Aggregate Amount Beneficially Owned by Each Reporting Person<br>669539.00 | Aggregate Amount Beneficially Owned by Each Reporting Person<br>669539.00 |
| 10. | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) [ ] | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) [ ] |
| 11. | Percent of Class Represented by Amount in Row (9)<br>5.2% | Percent of Class Represented by Amount in Row (9)<br>5.2% |
| 12. | Type of Reporting Person (See Instructions)<br>CO | Type of Reporting Person (See Instructions)<br>CO |

**Comment for Type of Reporting Person:** * N/A

---

**Item 1(a). Name of Issuer:**
OnKure Therapeutics Inc.

**Item 1(b). Address of Issuer's Principal Executive Offices:**
6707 Winchester Circle, Suite 400 Boulder, CO 80301

**Item 2(a). Name of Person Filing:**
Cantor Fitzgerald & Co., Cantor Fitzgerald Securities, Cantor Fitzgerald, L.P., CF Group Management and Inc. (collectively, the "Reporting Persons").

**Item 2(b). Address of Principal Business Office:**
110 East 59th Street
New York, New York 10022

**Item 2(c). Citizenship:**
Cantor Fitzgerald & Co. is a general partnership formed in New York, Cantor Fitzgerald Securities is a general partnership formed in New York, Cantor Fitzgerald, L.P. is a Delaware limited partnership, CF Group Management, Inc. is a New York corporation.

**Item 2(d). Title of Class of Securities:**
Class A Common Stock, par value $0.0001 per share

**Item 2(e). CUSIP Number:**
68277Q105

**Item 3. If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:**

(a) [ ] Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).

(b) [ ] Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).

(c) [ ] Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).

(d) [ ] Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8).

(e) [ ] An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);

(f) [ ] An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);

(g) [ ] A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);

(h) [ ] A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);

(i) [ ] A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);

(j) [ ] A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), if filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:

(k) [ ] Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).

**Item 4. Ownership:**

**(a) Amount beneficially owned:**

The responses to Items 5-11 of the cover pages of this Schedule 13G are incorporated herein by reference.
As of June 30, 2025, the Reporting Persons may be deemed to beneficially own an aggregate of 669,539 shares of Class A Common Stock, par value $0.0001 per share ("Common Stock") of OnKure Therapeutics, Inc. (the "Issuer"), representing 5.2% of the Issuer's outstanding Common Stock.
The percentage of the Common Stock held by the Reporting Persons is based on 12,823,872 shares of Common Stock outstanding as of May 5, 2025 as reported in the Issuer's Form 10-Q for the fiscal quarter ended March 31, 2025 filed with the Securities and Exchange Commission on May 6, 2025.
Cantor Fitzgerald & Co. ("CF&Co.") is the record holder of certain of the securities reported herein.
Cantor Fitzgerald Securities ("CFS") controls the managing general partner of CF&CO. Cantor Fitzgerald, L.P. ("CFLP") indirectly controls each of CFS and CF&CO. CFLP is controlled by CF Group Management, Inc. ("CFGM"), its managing general partner. As such, each of CFS, CFLP and CFGM may be deemed to have beneficial ownership of the securities directly held by CF&CO. Each such entity or person disclaims any beneficial ownership of the reported shares other than to the extent of any pecuniary interest they may have therein, directly or indirectly. On May 16, 2025, Howard W. Lutnick, in his capacity as trustee of a trust, entered into agreements to sell to trusts controlled by Brandon G. Lutnick all of the voting shares of CFGM. Following the closing of the transactions contemplated by such agreements, Brandon G. Lutnick will be deemed to have voting or dispositive power over the Common Stock held by CFGM. The closings of the transactions contemplated by such agreements are subject to the satisfaction of customary closing conditions, including receipt of required regulatory approvals. The transactions described herein follow Howard W. Lutnick's agreement to divest his interests in CFLP to comply with U.S. government ethics rules in connection with his appointment as the U.S. Secretary of Commerce.

**(b) Percent of class:**

See response to Item 11 on each cover page.

**(c) Number of shares as to which the person has:**

**(i) Sole power to vote or to direct the vote:**

See response to Item 5 on each cover page.

**(ii) Shared power to vote or to direct the vote:**

See response to Item 6 on each cover page.

**(iii) Sole power to dispose or to direct the disposition of:**

See response to Item 7 on each cover page.

**(iv) Shared power to dispose or to direct the disposition of:**

See response to Item 8 on each cover page.

**Item 5. Ownership of Five Percent or Less of a Class.**

[x] If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following.

**Item 6. Ownership of More than 5 Percent on Behalf of Another Person.**

Not Applicable

**Item 7. Identification and Classification of the Subsidiary**

Not Applicable

**Item 8. Identification and Classification of Members of the Group**

Not Applicable

**Item 9. Notice of Dissolution of Group**

Not Applicable

**Item 10. Certification:**

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

### SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Cantor Fitzgerald Securities**

**Date:** 08/14/2025

**By:** /s/ Pascal Bandelier

**Name & Title:** Pascal Bandelier/Co-Chief Executive Officer

**Cantor Fitzgerald & Co.**

**Date:** 08/14/2025

**By:** /s/ Pascal Bandelier

**Name & Title:** Pascal Bandelier/Co-Chief Executive Officer

**Cantor Fitzgerald, L.P.**

**Date:** 08/14/2025

**By:** /s/ Brandon Lutnick

**Name & Title:** Brandon Lutnick/Chairman & Chief Executive Officer

**CF Group Management, Inc.**

**Date:** 08/14/2025

**By:** /s/ Brandon Lutnick

**Name & Title:** Brandon Lutnick/Chairman & Chief Executive Officer