# EDGAR Filing Document

**Accession Number:** 0001906594
**File Stem:** 0001906594-25-000003
**Filing Date:** 2025-8
**Character Count:** 53223
**Document Hash:** f3cc2a500cd26439320e1e03d40ce894
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001906594-25-000003.hdr.sgml**: 20250828

**ACCESSION NUMBER**: 0001906594-25-000003

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20250630

**FILED AS OF DATE**: 20250828

**DATE AS OF CHANGE**: 20250828

**EFFECTIVENESS DATE**: 20250828

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** China Universal Asset Management Co., Ltd.
- **CENTRAL INDEX KEY:** 0001906594

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** F4
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-21774
- **FILM NUMBER:** 251267796

**BUSINESS ADDRESS:**
- **STREET 1:** CUAM BUILDING,728 WAIMA ROAD
- **CITY:** SHANGHAI
- **STATE:** F4
- **ZIP:** 200001
- **BUSINESS PHONE:** 862128932888

**MAIL ADDRESS:**
- **STREET 1:** CUAM BUILDING,728 WAIMA ROAD
- **CITY:** SHANGHAI
- **STATE:** F4
- **ZIP:** 200001

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 06-30-2025

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** China Universal Asset Management Co. Ltd.<br>**Address:** CUAM BUILDING728 WAIMA ROAD<br>SHANGHAI, F4 200001

**Form 13F File Number:** 028-21774

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Li Peng<br>**Title:** Chief Compliance Officer<br>**Phone:** 011-86-21-20373399

**Signature, Place, and Date of Signing:**

Li Peng  Shanghai, F4  07-21-2025<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 477

**Form 13F Information Table Value Total:** $1062737360

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| 10X GENOMICS INC-CLASS A | Common Stock | 88025U109 |  | 258385 | 22313 | SH |  | SOLE |  | 22313 | 0 | 0 |
| 4D MOLECULAR THERAPEUTICS IN | Common Stock | 35104E100 |  | 34518 | 9304 | SH |  | SOLE |  | 9304 | 0 | 0 |
| 89BIO INC | Common Stock | 282559103 |  | 287922 | 29320 | SH |  | SOLE |  | 29320 | 0 | 0 |
| ABBOTT LABORATORIES | Common Stock | 002824100 |  | 2726320 | 20045 | SH |  | SOLE |  | 20045 | 0 | 0 |
| ABBVIE INC | Common Stock | 00287Y109 |  | 2976788 | 16037 | SH |  | SOLE |  | 16037 | 0 | 0 |
| ABCELLERA BIOLOGICS INC | Common Stock | 00288U106 |  | 205625 | 59949 | SH |  | SOLE |  | 59949 | 0 | 0 |
| ABRDN PHYSICAL GOLD SHARES | ETP | 00326A104 |  | 4604840 | 146000 | SH |  | SOLE |  | 146000 | 0 | 0 |
| ABRDN PHYSICAL SILVER SHARES | ETP | 003264108 |  | 103230 | 3000 | SH |  | SOLE |  | 3000 | 0 | 0 |
| ABSCI CORP | Common Stock | 00091E109 |  | 65843 | 25620 | SH |  | SOLE |  | 25620 | 0 | 0 |
| AC IMMUNE SA | Common Stock | H00263105 |  | 40939 | 20167 | SH |  | SOLE |  | 20167 | 0 | 0 |
| ACADIA PHARMACEUTICALS INC | Common Stock | 004225108 |  | 725054 | 33614 | SH |  | SOLE |  | 33614 | 0 | 0 |
| ACCENTURE PLC-CL A | Common Stock | G1151C101 |  | 638728 | 2137 | SH |  | SOLE |  | 2137 | 0 | 0 |
| ACRIVON THERAPEUTICS INC | Common Stock | 004890109 |  | 7495 | 6298 | SH |  | SOLE |  | 6298 | 0 | 0 |
| ADAPTIVE BIOTECHNOLOGIES | Common Stock | 00650F109 |  | 355465 | 30512 | SH |  | SOLE |  | 30512 | 0 | 0 |
| ADMA BIOLOGICS INC | Common Stock | 000899104 |  | 873151 | 47949 | SH |  | SOLE |  | 47949 | 0 | 0 |
| ADOBE INC | Common Stock | 00724F101 |  | 5641484 | 14582 | SH |  | SOLE |  | 14582 | 0 | 0 |
| ADVANCED MICRO DEVICES | Common Stock | 007903107 |  | 8990500 | 63358 | SH |  | SOLE |  | 63358 | 0 | 0 |
| AGIOS PHARMACEUTICALS INC | Common Stock | 00847X104 |  | 386880 | 11632 | SH |  | SOLE |  | 11632 | 0 | 0 |
| AIRBNB INC-CLASS A | Common Stock | 009066101 |  | 1296800 | 9799 | SH |  | SOLE |  | 9799 | 0 | 0 |
| AKERO THERAPEUTICS INC | Common Stock | 00973Y108 |  | 854347 | 16011 | SH |  | SOLE |  | 16011 | 0 | 0 |
| ALECTOR INC | Common Stock | 014442107 |  | 28116 | 20083 | SH |  | SOLE |  | 20083 | 0 | 0 |
| ALIGN TECHNOLOGY INC | Common Stock | 016255101 |  | 25181 | 133 | SH |  | SOLE |  | 133 | 0 | 0 |
| ALKERMES PLC | Common Stock | G01767105 |  | 947563 | 33120 | SH |  | SOLE |  | 33120 | 0 | 0 |
| ALLOGENE THERAPEUTICS INC | Common Stock | 019770106 |  | 49642 | 43931 | SH |  | SOLE |  | 43931 | 0 | 0 |
| ALNYLAM PHARMACEUTICALS INC | Common Stock | 02043Q107 |  | 9070846 | 27817 | SH |  | SOLE |  | 27817 | 0 | 0 |
| ALPHA TEKNOVA INC | Common Stock | 02080L102 |  | 52699 | 10733 | SH |  | SOLE |  | 10733 | 0 | 0 |
| ALPHABET INC-CL A | Common Stock | 02079K305 |  | 25386284 | 144052 | SH |  | SOLE |  | 144052 | 0 | 0 |
| ALPHABET INC-CL C | Common Stock | 02079K107 |  | 11931961 | 67264 | SH |  | SOLE |  | 67264 | 0 | 0 |
| ALTIMMUNE INC | Common Stock | 02155H200 |  | 63042 | 16290 | SH |  | SOLE |  | 16290 | 0 | 0 |
| ALUMIS INC | Common Stock | 022307102 |  | 57591 | 19197 | SH |  | SOLE |  | 19197 | 0 | 0 |
| ALVOTECH SA | Common Stock | L01800108 |  | 488741 | 53590 | SH |  | SOLE |  | 53590 | 0 | 0 |
| AMARIN CORP PLC -ADR | ADR | 023111404 |  | 65221 | 4021 | SH |  | SOLE |  | 4021 | 0 | 0 |
| AMAZON.COM INC | Common Stock | 023135106 |  | 52856097 | 240923 | SH |  | SOLE |  | 240923 | 0 | 0 |
| AMER SPORTS INC | Common Stock | G0260P102 |  | 3261266 | 84140 | SH |  | SOLE |  | 84140 | 0 | 0 |
| AMERICAN ELECTRIC POWER | Common Stock | 025537101 |  | 1258505 | 12129 | SH |  | SOLE |  | 12129 | 0 | 0 |
| AMGEN INC | Common Stock | 031162100 |  | 16871823 | 60427 | SH |  | SOLE |  | 60427 | 0 | 0 |
| AMICUS THERAPEUTICS INC | Common Stock | 03152W109 |  | 354383 | 61847 | SH |  | SOLE |  | 61847 | 0 | 0 |
| AMNEAL PHARMACEUTICALS INC | Common Stock | 03168L105 |  | 509257 | 62949 | SH |  | SOLE |  | 62949 | 0 | 0 |
| AMPHASTAR PHARMACEUTICALS IN | Common Stock | 03209R103 |  | 217385 | 9468 | SH |  | SOLE |  | 9468 | 0 | 0 |
| AMPHENOL CORP-CL A | Common Stock | 032095101 |  | 4747128 | 48000 | SH |  | SOLE |  | 48000 | 0 | 0 |
| AMYLYX PHARMACEUTICALS INC | Common Stock | 03237H101 |  | 114765 | 17904 | SH |  | SOLE |  | 17904 | 0 | 0 |
| ANALOG DEVICES INC | Common Stock | 032654105 |  | 6823319 | 28667 | SH |  | SOLE |  | 28667 | 0 | 0 |
| ANAPTYSBIO INC | Common Stock | 032724106 |  | 131002 | 5901 | SH |  | SOLE |  | 5901 | 0 | 0 |
| ANAVEX LIFE SCIENCES CORP | Common Stock | 032797300 |  | 158095 | 17147 | SH |  | SOLE |  | 17147 | 0 | 0 |
| ANI PHARMACEUTICALS INC | Common Stock | 00182C103 |  | 283772 | 4349 | SH |  | SOLE |  | 4349 | 0 | 0 |
| ANNEXON INC | Common Stock | 03589W102 |  | 52886 | 22036 | SH |  | SOLE |  | 22036 | 0 | 0 |
| ANSYS INC | Common Stock | 03662Q105 |  | 701035 | 1996 | SH |  | SOLE |  | 1996 | 0 | 0 |
| APELLIS PHARMACEUTICALS INC | Common Stock | 03753U106 |  | 436956 | 25243 | SH |  | SOLE |  | 25243 | 0 | 0 |
| APOGEE THERAPEUTICS INC | Common Stock | 03770N101 |  | 618791 | 14248 | SH |  | SOLE |  | 14248 | 0 | 0 |
| APPLE INC | Common Stock | 037833100 |  | 48944740 | 238557 | SH |  | SOLE |  | 238557 | 0 | 0 |
| APPLIED MATERIALS INC | Common Stock | 038222105 |  | 3335535 | 18220 | SH |  | SOLE |  | 18220 | 0 | 0 |
| APPLIED OPTOELECTRONICS INC | Common Stock | 03823U102 |  | 770700 | 30000 | SH |  | SOLE |  | 30000 | 0 | 0 |
| APPLIED THERAPEUTICS INC | Common Stock | 03828A101 |  | 8846 | 28435 | SH |  | SOLE |  | 28435 | 0 | 0 |
| APPLOVIN CORP-CLASS A | Common Stock | 03831W108 |  | 7381787 | 21086 | SH |  | SOLE |  | 21086 | 0 | 0 |
| AQUESTIVE THERAPEUTICS INC | Common Stock | 03843E104 |  | 66035 | 19950 | SH |  | SOLE |  | 19950 | 0 | 0 |
| ARBUTUS BIOPHARMA CORP | Common Stock | 03879J100 |  | 118863 | 38467 | SH |  | SOLE |  | 38467 | 0 | 0 |
| ARCELLX INC | Common Stock | 03940C100 |  | 728828 | 11068 | SH |  | SOLE |  | 11068 | 0 | 0 |
| ARCTURUS THERAPEUTICS HOLDIN | Common Stock | 03969T109 |  | 70865 | 5447 | SH |  | SOLE |  | 5447 | 0 | 0 |
| ARCUTIS BIOTHERAPEUTICS INC | Common Stock | 03969K108 |  | 335653 | 23941 | SH |  | SOLE |  | 23941 | 0 | 0 |
| ARDELYX INC | Common Stock | 039697107 |  | 188368 | 48053 | SH |  | SOLE |  | 48053 | 0 | 0 |
| ARGENX SE - ADR | ADR | 04016X101 |  | 3491979 | 6335 | SH |  | SOLE |  | 6335 | 0 | 0 |
| ARM HOLDINGS PLC-ADR | ADR | 042068205 |  | 491204 | 3037 | SH |  | SOLE |  | 3037 | 0 | 0 |
| ARRIVENT BIOPHARMA INC | Common Stock | 04272N102 |  | 149582 | 6871 | SH |  | SOLE |  | 6871 | 0 | 0 |
| ARROWHEAD PHARMACEUTICALS IN | Common Stock | 04280A100 |  | 438245 | 27737 | SH |  | SOLE |  | 27737 | 0 | 0 |
| ARS PHARMACEUTICALS INC | Common Stock | 82835W108 |  | 344219 | 19726 | SH |  | SOLE |  | 19726 | 0 | 0 |
| ARTIVA BIOTHERAPEUTICS INC | Common Stock | 04317A107 |  | 7388 | 4893 | SH |  | SOLE |  | 4893 | 0 | 0 |
| ARVINAS INC | Common Stock | 04335A105 |  | 107898 | 14660 | SH |  | SOLE |  | 14660 | 0 | 0 |
| ASCENDIS PHARMA A/S - ADR | ADR | 04351P101 |  | 2103304 | 12186 | SH |  | SOLE |  | 12186 | 0 | 0 |
| ASML HOLDING NV-NY REG SHS | NY Reg Shrs | N07059210 |  | 2392149 | 2985 | SH |  | SOLE |  | 2985 | 0 | 0 |
| ASTERA LABS INC | Common Stock | 04626A103 |  | 922284 | 10200 | SH |  | SOLE |  | 10200 | 0 | 0 |
| ASTRAZENECA PLC-SPONS ADR | ADR | 046353108 |  | 10412609 | 149007 | SH |  | SOLE |  | 149007 | 0 | 0 |
| ASTRIA THERAPEUTICS INC | Common Stock | 04635X102 |  | 60756 | 11335 | SH |  | SOLE |  | 11335 | 0 | 0 |
| AT INC | Common Stock | 00206R102 |  | 708972 | 24498 | SH |  | SOLE |  | 24498 | 0 | 0 |
| ATEA PHARMACEUTICALS INC | Common Stock | 04683R106 |  | 61877 | 17188 | SH |  | SOLE |  | 17188 | 0 | 0 |
| ATLASSIAN CORP-CL A | Common Stock | 049468101 |  | 1310337 | 6452 | SH |  | SOLE |  | 6452 | 0 | 0 |
| AURA BIOSCIENCES INC | Common Stock | 05153U107 |  | 77956 | 12453 | SH |  | SOLE |  | 12453 | 0 | 0 |
| AURINIA PHARMACEUTICALS INC | Common Stock | 05156V102 |  | 229833 | 27135 | SH |  | SOLE |  | 27135 | 0 | 0 |
| AUTODESK INC | Common Stock | 052769106 |  | 2835352 | 9159 | SH |  | SOLE |  | 9159 | 0 | 0 |
| AUTOLIV INC | Common Stock | 052800109 |  | 223800 | 2000 | SH |  | SOLE |  | 2000 | 0 | 0 |
| AUTOLUS THERAPEUTICS PLC | ADR | 05280R100 |  | 91822 | 40273 | SH |  | SOLE |  | 40273 | 0 | 0 |
| AUTOMATIC DATA PROCESSING | Common Stock | 053015103 |  | 2855682 | 9216 | SH |  | SOLE |  | 9216 | 0 | 0 |
| AUTOZONE INC | Common Stock | 053332102 |  | 371223 | 100 | SH |  | SOLE |  | 100 | 0 | 0 |
| AVADEL PHARMACEUTICALS | Common Stock | G29687103 |  | 171956 | 19430 | SH |  | SOLE |  | 19430 | 0 | 0 |
| AVIDITY BIOSCIENCES INC | Common Stock | 05370A108 |  | 687564 | 24210 | SH |  | SOLE |  | 24210 | 0 | 0 |
| AXON ENTERPRISE INC | Common Stock | 05464C101 |  | 1463798 | 1768 | SH |  | SOLE |  | 1768 | 0 | 0 |
| AXSOME THERAPEUTICS INC | Common Stock | 05464T104 |  | 1032313 | 9889 | SH |  | SOLE |  | 9889 | 0 | 0 |
| BAKER HUGHES CO | Common Stock | 05722G100 |  | 862458 | 22495 | SH |  | SOLE |  | 22495 | 0 | 0 |
| BANK OF AMERICA CORP | Common Stock | 060505104 |  | 1166722 | 24656 | SH |  | SOLE |  | 24656 | 0 | 0 |
| BEAM THERAPEUTICS INC | Common Stock | 07373V105 |  | 343551 | 20197 | SH |  | SOLE |  | 20197 | 0 | 0 |
| BEONE MEDICINES LTD-ADR | ADR | 07725L102 |  | 2007487 | 8293 | SH |  | SOLE |  | 8293 | 0 | 0 |
| BERKSHIRE HATHAWAY INC-CL B | Common Stock | 084670702 |  | 2221426 | 4573 | SH |  | SOLE |  | 4573 | 0 | 0 |
| BICYCLE THERAPEUTICS PLC-ADR | ADR | 088786108 |  | 61619 | 8866 | SH |  | SOLE |  | 8866 | 0 | 0 |
| BIOCRYST PHARMACEUTICALS INC | Common Stock | 09058V103 |  | 376562 | 42027 | SH |  | SOLE |  | 42027 | 0 | 0 |
| BIOGEN INC | Common Stock | 09062X103 |  | 4113952 | 32757 | SH |  | SOLE |  | 32757 | 0 | 0 |
| BIOHAVEN LTD | Common Stock | G1110E107 |  | 282200 | 20000 | SH |  | SOLE |  | 20000 | 0 | 0 |
| BIOMARIN PHARMACEUTICAL INC | Common Stock | 09061G101 |  | 2137783 | 38890 | SH |  | SOLE |  | 38890 | 0 | 0 |
| BIOMEA FUSION INC | Common Stock | 09077A106 |  | 13583 | 7546 | SH |  | SOLE |  | 7546 | 0 | 0 |
| BIONTECH SE-ADR | ADR | 09075V102 |  | 2136321 | 20065 | SH |  | SOLE |  | 20065 | 0 | 0 |
| BLUEPRINT MEDICINES CORP | Common Stock | 09627Y109 |  | 1662623 | 12971 | SH |  | SOLE |  | 12971 | 0 | 0 |
| BOOKING HOLDINGS INC | Common Stock | 09857L108 |  | 7751792 | 1339 | SH |  | SOLE |  | 1339 | 0 | 0 |
| BOSTON SCIENTIFIC CORP | Common Stock | 101137107 |  | 2854528 | 26576 | SH |  | SOLE |  | 26576 | 0 | 0 |
| BRIDGEBIO PHARMA INC | Common Stock | 10806X102 |  | 1646756 | 38137 | SH |  | SOLE |  | 38137 | 0 | 0 |
| BRITISH AMERICAN TOB-SP ADR | ADR | 110448107 |  | 2817042 | 59073 | SH |  | SOLE |  | 59073 | 0 | 0 |
| BROADCOM INC | Common Stock | 11135F101 |  | 37696240 | 136754 | SH |  | SOLE |  | 136754 | 0 | 0 |
| C4 THERAPEUTICS INC | Common Stock | 12529R107 |  | 20393 | 14261 | SH |  | SOLE |  | 14261 | 0 | 0 |
| CADENCE DESIGN SYS INC | Common Stock | 127387108 |  | 2957932 | 9599 | SH |  | SOLE |  | 9599 | 0 | 0 |
| CARGO THERAPEUTICS INC | Common Stock | 14179K101 |  | 38159 | 9262 | SH |  | SOLE |  | 9262 | 0 | 0 |
| CARTESIAN THERAPEUTICS INC | Common Stock | 816212302 |  | 54163 | 5213 | SH |  | SOLE |  | 5213 | 0 | 0 |
| CASTLE BIOSCIENCES INC | Common Stock | 14843C105 |  | 118416 | 5799 | SH |  | SOLE |  | 5799 | 0 | 0 |
| CDW CORP/DE | Common Stock | 12514G108 |  | 533984 | 2990 | SH |  | SOLE |  | 2990 | 0 | 0 |
| CELESTICA INC | Common Stock | 15101Q207 |  | 1873320 | 12000 | SH |  | SOLE |  | 12000 | 0 | 0 |
| CENTESSA PHARMACEUTICALS-ADR | ADR | 152309100 |  | 252038 | 19181 | SH |  | SOLE |  | 19181 | 0 | 0 |
| CG ONCOLOGY INC | Common Stock | 156944100 |  | 398060 | 15310 | SH |  | SOLE |  | 15310 | 0 | 0 |
| CHAGEE HOLDINGS LTD-ADR | ADR | 15743P104 |  | 204128 | 7818 | SH |  | SOLE |  | 7818 | 0 | 0 |
| CHARLES RIVER LABORATORIES | Common Stock | 159864107 |  | 13504 | 89 | SH |  | SOLE |  | 89 | 0 | 0 |
| CHARTER COMMUNICATIONS INC-A | Common Stock | 16119P108 |  | 1302877 | 3187 | SH |  | SOLE |  | 3187 | 0 | 0 |
| CHEVRON CORP | Common Stock | 166764100 |  | 810885 | 5663 | SH |  | SOLE |  | 5663 | 0 | 0 |
| CHIPOTLE MEXICAN GRILL INC | Common Stock | 169656105 |  | 1176960 | 20961 | SH |  | SOLE |  | 20961 | 0 | 0 |
| CINTAS CORP | Common Stock | 172908105 |  | 2043272 | 9168 | SH |  | SOLE |  | 9168 | 0 | 0 |
| CIRCLE INTERNET GROUP INC | Common Stock | 172573107 |  | 725160 | 4000 | SH |  | SOLE |  | 4000 | 0 | 0 |
| CISCO SYSTEMS INC | Common Stock | 17275R102 |  | 7179928 | 103487 | SH |  | SOLE |  | 103487 | 0 | 0 |
| CLIMB BIO INC | Common Stock | 28658R106 |  | 16829 | 13572 | SH |  | SOLE |  | 13572 | 0 | 0 |
| COCA-COLA CO/THE | Common Stock | 191216100 |  | 996072 | 13953 | SH |  | SOLE |  | 13953 | 0 | 0 |
| COCA-COLA EUROPACIFIC PARTNE | Common Stock | G25839104 |  | 966791 | 10427 | SH |  | SOLE |  | 10427 | 0 | 0 |
| CODEXIS INC | Common Stock | 192005106 |  | 40599 | 16639 | SH |  | SOLE |  | 16639 | 0 | 0 |
| COGENT BIOSCIENCES INC | Common Stock | 19240Q201 |  | 164192 | 22868 | SH |  | SOLE |  | 22868 | 0 | 0 |
| COGNIZANT TECH SOLUTIONS-A | Common Stock | 192446102 |  | 873312 | 11192 | SH |  | SOLE |  | 11192 | 0 | 0 |
| COLLEGIUM PHARMACEUTICAL INC | Common Stock | 19459J104 |  | 190904 | 6456 | SH |  | SOLE |  | 6456 | 0 | 0 |
| COMCAST CORP-CLASS A | Common Stock | 20030N101 |  | 3017875 | 84558 | SH |  | SOLE |  | 84558 | 0 | 0 |
| COMPASS PATHWAYS PLC | ADR | 20451W101 |  | 51162 | 18272 | SH |  | SOLE |  | 18272 | 0 | 0 |
| CONSTELLATION BRANDS INC-A | Common Stock | 21036P108 |  | 213762 | 1314 | SH |  | SOLE |  | 1314 | 0 | 0 |
| CONSTELLATION ENERGY | Common Stock | 21037T109 |  | 2296760 | 7116 | SH |  | SOLE |  | 7116 | 0 | 0 |
| CONSUMER DISCRETIONARY SELT | ETP | 81369Y407 |  | 655250 | 3015 | SH |  | SOLE |  | 3015 | 0 | 0 |
| COPART INC | Common Stock | 217204106 |  | 1076350 | 21935 | SH |  | SOLE |  | 21935 | 0 | 0 |
| CORMEDIX INC | Common Stock | 21900C308 |  | 167823 | 13622 | SH |  | SOLE |  | 13622 | 0 | 0 |
| CORVUS PHARMACEUTICALS INC | Common Stock | 221015100 |  | 61952 | 15488 | SH |  | SOLE |  | 15488 | 0 | 0 |
| COSTAR GROUP INC | Common Stock | 22160N109 |  | 770152 | 9579 | SH |  | SOLE |  | 9579 | 0 | 0 |
| COSTCO WHOLESALE CORP | Common Stock | 22160K105 |  | 14441245 | 14588 | SH |  | SOLE |  | 14588 | 0 | 0 |
| CREDO TECHNOLOGY GROUP HOLDI | Common Stock | G25457105 |  | 1296260 | 14000 | SH |  | SOLE |  | 14000 | 0 | 0 |
| CRINETICS PHARMACEUTICALS IN | Common Stock | 22663K107 |  | 541119 | 18815 | SH |  | SOLE |  | 18815 | 0 | 0 |
| CRISPR THERAPEUTICS AG | Common Stock | H17182108 |  | 843709 | 17346 | SH |  | SOLE |  | 17346 | 0 | 0 |
| CROWDSTRIKE HOLDINGS INC - A | Common Stock | 22788C105 |  | 4153423 | 8155 | SH |  | SOLE |  | 8155 | 0 | 0 |
| CSX CORP | Common Stock | 126408103 |  | 1391735 | 42652 | SH |  | SOLE |  | 42652 | 0 | 0 |
| CULLINAN THERAPEUTICS INC | Common Stock | 230031106 |  | 89253 | 11853 | SH |  | SOLE |  | 11853 | 0 | 0 |
| CUREVAC NV | Common Stock | N2451R105 |  | 245555 | 45222 | SH |  | SOLE |  | 45222 | 0 | 0 |
| CVS HEALTH CORP | Common Stock | 126650100 |  | 2069400 | 30000 | SH |  | SOLE |  | 30000 | 0 | 0 |
| CYBERARK SOFTWARE LTD/ISRAEL | Common Stock | M2682V108 |  | 1851304 | 4550 | SH |  | SOLE |  | 4550 | 0 | 0 |
| CYTOKINETICS INC | Common Stock | 23282W605 |  | 792530 | 23987 | SH |  | SOLE |  | 23987 | 0 | 0 |
| DANAHER CORP | Common Stock | 235851102 |  | 791312 | 4000 | SH |  | SOLE |  | 4000 | 0 | 0 |
| DATADOG INC - CLASS A | Common Stock | 23804L103 |  | 974430 | 7254 | SH |  | SOLE |  | 7254 | 0 | 0 |
| DAY ONE BIOPHARMACEUTICALS I | Common Stock | 23954D109 |  | 132327 | 20358 | SH |  | SOLE |  | 20358 | 0 | 0 |
| DECKERS OUTDOOR CORP | Common Stock | 243537107 |  | 402798 | 3908 | SH |  | SOLE |  | 3908 | 0 | 0 |
| DENALI THERAPEUTICS INC | Common Stock | 24823R105 |  | 408200 | 29178 | SH |  | SOLE |  | 29178 | 0 | 0 |
| DESIGN THERAPEUTICS INC | Common Stock | 25056L103 |  | 38425 | 11402 | SH |  | SOLE |  | 11402 | 0 | 0 |
| DEXCOM INC | Common Stock | 252131107 |  | 796609 | 9126 | SH |  | SOLE |  | 9126 | 0 | 0 |
| DIAGEO PLC-SPONSORED ADR | ADR | 25243Q205 |  | 415158 | 4117 | SH |  | SOLE |  | 4117 | 0 | 0 |
| DIAMONDBACK ENERGY INC | Common Stock | 25278X109 |  | 911512 | 6634 | SH |  | SOLE |  | 6634 | 0 | 0 |
| DISC MEDICINE INC | Common Stock | 254604101 |  | 368390 | 6956 | SH |  | SOLE |  | 6956 | 0 | 0 |
| DOORDASH INC - A | Common Stock | 25809K105 |  | 4634881 | 18802 | SH |  | SOLE |  | 18802 | 0 | 0 |
| DUOLINGO | Common Stock | 26603R106 |  | 1722084 | 4200 | SH |  | SOLE |  | 4200 | 0 | 0 |
| DYNAVAX TECHNOLOGIES CORP | Common Stock | 268158201 |  | 239251 | 24118 | SH |  | SOLE |  | 24118 | 0 | 0 |
| DYNE THERAPEUTICS INC | Common Stock | 26818M108 |  | 217332 | 22829 | SH |  | SOLE |  | 22829 | 0 | 0 |
| EDGEWISE THERAPEUTICS INC | Common Stock | 28036F105 |  | 276883 | 21120 | SH |  | SOLE |  | 21120 | 0 | 0 |
| EDITAS MEDICINE INC | Common Stock | 28106W103 |  | 36989 | 16813 | SH |  | SOLE |  | 16813 | 0 | 0 |
| EDWARDS LIFESCIENCES CORP | Common Stock | 28176E108 |  | 20022 | 256 | SH |  | SOLE |  | 256 | 0 | 0 |
| ELECTRONIC ARTS INC | Common Stock | 285512109 |  | 909332 | 5694 | SH |  | SOLE |  | 5694 | 0 | 0 |
| ELEVANCE HEALTH INC | Common Stock | 036752103 |  | 1400256 | 3600 | SH |  | SOLE |  | 3600 | 0 | 0 |
| ELI LILLY  CO | Common Stock | 532457108 |  | 6041358 | 7750 | SH |  | SOLE |  | 7750 | 0 | 0 |
| ENANTA PHARMACEUTICALS INC | Common Stock | 29251M106 |  | 32455 | 4293 | SH |  | SOLE |  | 4293 | 0 | 0 |
| ENLIVEN THERAPEUTICS INC | Common Stock | 29337E102 |  | 197691 | 9855 | SH |  | SOLE |  | 9855 | 0 | 0 |
| ENTRADA THERAPEUTICS INC | Common Stock | 29384C108 |  | 51227 | 7623 | SH |  | SOLE |  | 7623 | 0 | 0 |
| ERASCA INC | Common Stock | 29479A108 |  | 72259 | 56897 | SH |  | SOLE |  | 56897 | 0 | 0 |
| ESPERION THERAPEUTICS INC | Common Stock | 29664W105 |  | 39187 | 39808 | SH |  | SOLE |  | 39808 | 0 | 0 |
| EVOLUS INC | Common Stock | 30052C107 |  | 119270 | 12950 | SH |  | SOLE |  | 12950 | 0 | 0 |
| EXACT SCIENCES CORP | Common Stock | 30063P105 |  | 64618 | 1216 | SH |  | SOLE |  | 1216 | 0 | 0 |
| EXELIXIS INC | Common Stock | 30161Q104 |  | 2414076 | 54772 | SH |  | SOLE |  | 54772 | 0 | 0 |
| EXELON CORP | Common Stock | 30161N101 |  | 995230 | 22921 | SH |  | SOLE |  | 22921 | 0 | 0 |
| EXXON MOBIL CORP | Common Stock | 30231G102 |  | 1591344 | 14762 | SH |  | SOLE |  | 14762 | 0 | 0 |
| EYEPOINT PHARMACEUTICALS INC | Common Stock | 30233G209 |  | 130056 | 13821 | SH |  | SOLE |  | 13821 | 0 | 0 |
| FASTENAL CO | Common Stock | 311900104 |  | 1094016 | 26048 | SH |  | SOLE |  | 26048 | 0 | 0 |
| FATE THERAPEUTICS INC | Common Stock | 31189P102 |  | 25787 | 23024 | SH |  | SOLE |  | 23024 | 0 | 0 |
| FERRARI NV | Common Stock | N3167Y103 |  | 509879 | 1039 | SH |  | SOLE |  | 1039 | 0 | 0 |
| FIRST TRUST SENIOR LOAN ETF | ETP | 33738D309 |  | 459 | 10 | SH |  | SOLE |  | 10 | 0 | 0 |
| FISERV INC | Common Stock | 337738108 |  | 1094804 | 6350 | SH |  | SOLE |  | 6350 | 0 | 0 |
| FOGHORN THERAPEUTICS INC | Common Stock | 344174107 |  | 52617 | 11195 | SH |  | SOLE |  | 11195 | 0 | 0 |
| FORTINET INC | Common Stock | 34959E109 |  | 3000122 | 28378 | SH |  | SOLE |  | 28378 | 0 | 0 |
| FORTREA HOLDINGS INC | Common Stock | 34965K107 |  | 89794 | 18177 | SH |  | SOLE |  | 18177 | 0 | 0 |
| FRANKLIN SENIOR LOAN ETF | ETP | 35473P595 |  | 218070 | 9000 | SH |  | SOLE |  | 9000 | 0 | 0 |
| FULL TRUCK ALLIANCE -SPN ADR | ADR | 35969L108 |  | 3566620 | 302000 | SH |  | SOLE |  | 302000 | 0 | 0 |
| GALAPAGOS NV-SPON ADR | ADR | 36315X101 |  | 83298 | 2976 | SH |  | SOLE |  | 2976 | 0 | 0 |
| GE HEALTHCARE TECHNOLOGY | Common Stock | 36266G107 |  | 770032 | 10396 | SH |  | SOLE |  | 10396 | 0 | 0 |
| GENERAL ELECTRIC | Common Stock | 369604301 |  | 936900 | 3640 | SH |  | SOLE |  | 3640 | 0 | 0 |
| GENMAB A/S -SP ADR | ADR | 372303206 |  | 380578 | 18421 | SH |  | SOLE |  | 18421 | 0 | 0 |
| GERON CORP | Common Stock | 374163103 |  | 180370 | 127922 | SH |  | SOLE |  | 127922 | 0 | 0 |
| GILEAD SCIENCES INC | Common Stock | 375558103 |  | 17126643 | 154475 | SH |  | SOLE |  | 154475 | 0 | 0 |
| GLOBALFOUNDRIES INC | Common Stock | G39387108 |  | 479563 | 12554 | SH |  | SOLE |  | 12554 | 0 | 0 |
| GOLDMAN SACHS GROUP INC | Common Stock | 38141G104 |  | 750923 | 1061 | SH |  | SOLE |  | 1061 | 0 | 0 |
| GOLDMAN SACHS PHYSICAL GOLD | ETP | 38150K103 |  | 7581760 | 232000 | SH |  | SOLE |  | 232000 | 0 | 0 |
| GRAIL INC | Common Stock | 384747101 |  | 397220 | 7725 | SH |  | SOLE |  | 7725 | 0 | 0 |
| GRANITESHARES GOLD TRUST | ETP | 38748G101 |  | 9889920 | 303000 | SH |  | SOLE |  | 303000 | 0 | 0 |
| GRIFOLS SA-ADR | ADR | 398438408 |  | 221498 | 24502 | SH |  | SOLE |  | 24502 | 0 | 0 |
| GSK PLC-SPON ADR | ADR | 37733W204 |  | 13122 | 338 | SH |  | SOLE |  | 338 | 0 | 0 |
| GUARDANT HEALTH INC | Common Stock | 40131M109 |  | 1294859 | 24882 | SH |  | SOLE |  | 24882 | 0 | 0 |
| H WORLD GROUP LTD-ADR | ADR | 44332N106 |  | 345984 | 10200 | SH |  | SOLE |  | 10200 | 0 | 0 |
| HALOZYME THERAPEUTICS INC | Common Stock | 40637H109 |  | 1287391 | 24748 | SH |  | SOLE |  | 24748 | 0 | 0 |
| HARMONY BIOSCIENCES HOLDINGS | Common Stock | 413197104 |  | 364443 | 11533 | SH |  | SOLE |  | 11533 | 0 | 0 |
| HARROW INC | Common Stock | 415858109 |  | 225110 | 7371 | SH |  | SOLE |  | 7371 | 0 | 0 |
| HERSHEY CO/THE | Common Stock | 427866108 |  | 1660 | 10 | SH |  | SOLE |  | 10 | 0 | 0 |
| HESAI GROUP | ADR | 428050108 |  | 439000 | 20000 | SH |  | SOLE |  | 20000 | 0 | 0 |
| HILTON WORLDWIDE HOLDINGS IN | Common Stock | 43300A203 |  | 271933 | 1021 | SH |  | SOLE |  | 1021 | 0 | 0 |
| HOME DEPOT INC | Common Stock | 437076102 |  | 4503072 | 12282 | SH |  | SOLE |  | 12282 | 0 | 0 |
| HONEYWELL INTERNATIONAL INC | Common Stock | 438516106 |  | 3398185 | 14592 | SH |  | SOLE |  | 14592 | 0 | 0 |
| HUMACYTE INC | Common Stock | 44486Q103 |  | 65114 | 31155 | SH |  | SOLE |  | 31155 | 0 | 0 |
| HUTCHMED CHINA-ADR | ADR | 44842L103 |  | 93762 | 6230 | SH |  | SOLE |  | 6230 | 0 | 0 |
| IDEAYA BIOSCIENCES INC | Common Stock | 45166A102 |  | 369742 | 17590 | SH |  | SOLE |  | 17590 | 0 | 0 |
| IDEXX LABORATORIES INC | Common Stock | 45168D104 |  | 1376248 | 2566 | SH |  | SOLE |  | 2566 | 0 | 0 |
| IGM BIOSCIENCES INC | Common Stock | 449585108 |  | 7812 | 6975 | SH |  | SOLE |  | 6975 | 0 | 0 |
| ILLUMINA INC | Common Stock | 452327109 |  | 13930 | 146 | SH |  | SOLE |  | 146 | 0 | 0 |
| IMMUNITYBIO INC | Common Stock | 45256X103 |  | 467995 | 177271 | SH |  | SOLE |  | 177271 | 0 | 0 |
| IMMUNOCORE HOLDINGS PLC-ADR | ADR | 45258D105 |  | 250475 | 7982 | SH |  | SOLE |  | 7982 | 0 | 0 |
| IMMUNOVANT INC | Common Stock | 45258J102 |  | 549264 | 34329 | SH |  | SOLE |  | 34329 | 0 | 0 |
| INCYTE CORP | Common Stock | 45337C102 |  | 2647592 | 38878 | SH |  | SOLE |  | 38878 | 0 | 0 |
| INDIVIOR PLC | Common Stock | G4766E116 |  | 369370 | 25059 | SH |  | SOLE |  | 25059 | 0 | 0 |
| INHIBRX BIOSCIENCES INC | Common Stock | 45720N103 |  | 41483 | 2907 | SH |  | SOLE |  | 2907 | 0 | 0 |
| INNOVIVA INC | Common Stock | 45781M101 |  | 253295 | 12608 | SH |  | SOLE |  | 12608 | 0 | 0 |
| INSMED INC | Common Stock | 457669307 |  | 3681612 | 36582 | SH |  | SOLE |  | 36582 | 0 | 0 |
| INSPIRE MEDICAL SYSTEMS INC | Common Stock | 457730109 |  | 204258 | 1574 | SH |  | SOLE |  | 1574 | 0 | 0 |
| INTEL CORP | Common Stock | 458140100 |  | 2218451 | 99038 | SH |  | SOLE |  | 99038 | 0 | 0 |
| INTELLIA THERAPEUTICS INC | Common Stock | 45826J105 |  | 195142 | 20804 | SH |  | SOLE |  | 20804 | 0 | 0 |
| INTL BUSINESS MACHINES CORP | Common Stock | 459200101 |  | 932979 | 3165 | SH |  | SOLE |  | 3165 | 0 | 0 |
| INTUIT INC | Common Stock | 461202103 |  | 9165650 | 11637 | SH |  | SOLE |  | 11637 | 0 | 0 |
| INTUITIVE SURGICAL INC | Common Stock | 46120E602 |  | 5086861 | 9361 | SH |  | SOLE |  | 9361 | 0 | 0 |
| INVESCO QQQ TRUST SERIES 1 | ETP | 46090E103 |  | 524563 | 950 | SH |  | SOLE |  | 950 | 0 | 0 |
| INVESCO SENIOR LOAN ETF | ETP | 46138G508 |  | 62174 | 2972 | SH |  | SOLE |  | 2972 | 0 | 0 |
| IONIS PHARMACEUTICALS INC | Common Stock | 462222100 |  | 1262977 | 31966 | SH |  | SOLE |  | 31966 | 0 | 0 |
| IOVANCE BIOTHERAPEUTICS INC | Common Stock | 462260100 |  | 115359 | 67069 | SH |  | SOLE |  | 67069 | 0 | 0 |
| IQVIA HOLDINGS INC | Common Stock | 46266C105 |  | 551565 | 3500 | SH |  | SOLE |  | 3500 | 0 | 0 |
| IRONWOOD PHARMACEUTICALS INC | Common Stock | 46333X108 |  | 23310 | 32501 | SH |  | SOLE |  | 32501 | 0 | 0 |
| ISHARES GOLD TRUST | ETP | 464285204 |  | 2868560 | 46000 | SH |  | SOLE |  | 46000 | 0 | 0 |
| ISHARES GOLD TRUST MICRO | ETP | 46436F103 |  | 13608375 | 412500 | SH |  | SOLE |  | 412500 | 0 | 0 |
| ISHARES RUSSELL TOP 200 GROW | ETP | 464289438 |  | 247 | 1 | SH |  | SOLE |  | 1 | 0 | 0 |
| ISHARES SILVER TRUST | ETP | 46428Q109 |  | 2178584 | 66400 | SH |  | SOLE |  | 66400 | 0 | 0 |
| ITEOS THERAPEUTICS INC | Common Stock | 46565G104 |  | 76639 | 7687 | SH |  | SOLE |  | 7687 | 0 | 0 |
| JANUX THERAPEUTICS INC | Common Stock | 47103J105 |  | 274544 | 11885 | SH |  | SOLE |  | 11885 | 0 | 0 |
| JAZZ PHARMACEUTICALS PLC | Common Stock | G50871105 |  | 1314084 | 12383 | SH |  | SOLE |  | 12383 | 0 | 0 |
| JOHNSON  JOHNSON | Common Stock | 478160104 |  | 2487228 | 16283 | SH |  | SOLE |  | 16283 | 0 | 0 |
| JPMORGAN CHASE  CO | Common Stock | 46625H100 |  | 2766611 | 9543 | SH |  | SOLE |  | 9543 | 0 | 0 |
| KALVISTA PHARMACEUTICALS INC | Common Stock | 483497103 |  | 112880 | 9985 | SH |  | SOLE |  | 9985 | 0 | 0 |
| KANZHUN LTD - ADR | ADR | 48553T106 |  | 82064 | 4600 | SH |  | SOLE |  | 4600 | 0 | 0 |
| KE HOLDINGS INC-ADR | ADR | 482497104 |  | 798300 | 45000 | SH |  | SOLE |  | 45000 | 0 | 0 |
| KEROS THERAPEUTICS INC | Common Stock | 492327101 |  | 108896 | 8157 | SH |  | SOLE |  | 8157 | 0 | 0 |
| KEURIG DR PEPPER INC | Common Stock | 49271V100 |  | 1025854 | 30837 | SH |  | SOLE |  | 30837 | 0 | 0 |
| KINIKSA PHARMACEUTICALS INTE | Common Stock | G52694109 |  | 235278 | 8503 | SH |  | SOLE |  | 8503 | 0 | 0 |
| KLA CORP | Common Stock | 482480100 |  | 6836288 | 7632 | SH |  | SOLE |  | 7632 | 0 | 0 |
| KRAFT HEINZ CO/THE | Common Stock | 500754106 |  | 693835 | 26872 | SH |  | SOLE |  | 26872 | 0 | 0 |
| KRYSTAL BIOTECH INC | Common Stock | 501147102 |  | 797818 | 5804 | SH |  | SOLE |  | 5804 | 0 | 0 |
| KURA ONCOLOGY INC | Common Stock | 50127T109 |  | 100329 | 17388 | SH |  | SOLE |  | 17388 | 0 | 0 |
| KYMERA THERAPEUTICS INC | Common Stock | 501575104 |  | 1007168 | 23079 | SH |  | SOLE |  | 23079 | 0 | 0 |
| KYVERNA THERAPEUTICS INC | Common Stock | 501976104 |  | 26648 | 8680 | SH |  | SOLE |  | 8680 | 0 | 0 |
| LAM RESEARCH CORP | Common Stock | 512807306 |  | 3417257 | 35042 | SH |  | SOLE |  | 35042 | 0 | 0 |
| LARIMAR THERAPEUTICS INC | Common Stock | 517125100 |  | 37165 | 12860 | SH |  | SOLE |  | 12860 | 0 | 0 |
| LEGEND BIOTECH CORP-ADR | ADR | 52490G102 |  | 582249 | 16406 | SH |  | SOLE |  | 16406 | 0 | 0 |
| LENZ THERAPEUTICS INC | Common Stock | 52635N103 |  | 165689 | 5653 | SH |  | SOLE |  | 5653 | 0 | 0 |
| LEXEO THERAPEUTICS INC | Common Stock | 52886X107 |  | 26801 | 6667 | SH |  | SOLE |  | 6667 | 0 | 0 |
| LEXICON PHARMACEUTICALS INC | Common Stock | 528872302 |  | 68982 | 72943 | SH |  | SOLE |  | 72943 | 0 | 0 |
| LI AUTO INC - ADR | ADR | 50202M102 |  | 731970 | 27000 | SH |  | SOLE |  | 27000 | 0 | 0 |
| LIGAND PHARMACEUTICALS | Common Stock | 53220K504 |  | 440510 | 3875 | SH |  | SOLE |  | 3875 | 0 | 0 |
| LINDE PLC | Common Stock | G54950103 |  | 5771852 | 12302 | SH |  | SOLE |  | 12302 | 0 | 0 |
| LOWE'S COS INC | Common Stock | 548661107 |  | 1095372 | 4937 | SH |  | SOLE |  | 4937 | 0 | 0 |
| LULULEMON ATHLETICA INC | Common Stock | 550021109 |  | 826303 | 3478 | SH |  | SOLE |  | 3478 | 0 | 0 |
| LYELL IMMUNOPHARMA INC | Common Stock | 55083R203 |  | 26219 | 2966 | SH |  | SOLE |  | 2966 | 0 | 0 |
| MACROGENICS INC | Common Stock | 556099109 |  | 15332 | 12671 | SH |  | SOLE |  | 12671 | 0 | 0 |
| MADRIGAL PHARMACEUTICALS INC | Common Stock | 558868105 |  | 1349472 | 4459 | SH |  | SOLE |  | 4459 | 0 | 0 |
| MANNKIND CORP | Common Stock | 56400P706 |  | 228305 | 61044 | SH |  | SOLE |  | 61044 | 0 | 0 |
| MARAVAI LIFESCIENCES HLDGS-A | Common Stock | 56600D107 |  | 69690 | 28917 | SH |  | SOLE |  | 28917 | 0 | 0 |
| MARRIOTT INTERNATIONAL -CL A | Common Stock | 571903202 |  | 1699093 | 6219 | SH |  | SOLE |  | 6219 | 0 | 0 |
| MARVELL TECHNOLOGY INC | Common Stock | 573874104 |  | 1515182 | 19576 | SH |  | SOLE |  | 19576 | 0 | 0 |
| MASTERCARD INC - A | Common Stock | 57636Q104 |  | 5422159 | 9649 | SH |  | SOLE |  | 9649 | 0 | 0 |
| MAXCYTE INC | Common Stock | 57777K106 |  | 46552 | 21354 | SH |  | SOLE |  | 21354 | 0 | 0 |
| MCDONALD'S CORP | Common Stock | 580135101 |  | 712895 | 2440 | SH |  | SOLE |  | 2440 | 0 | 0 |
| MCKESSON CORP | Common Stock | 58155Q103 |  | 1135333 | 1548 | SH |  | SOLE |  | 1548 | 0 | 0 |
| MEDPACE HOLDINGS INC | Common Stock | 58506Q109 |  | 1811914 | 5773 | SH |  | SOLE |  | 5773 | 0 | 0 |
| MEIRAGTX HOLDINGS PLC | Common Stock | G59665102 |  | 105239 | 16141 | SH |  | SOLE |  | 16141 | 0 | 0 |
| MERCADOLIBRE INC | Common Stock | 58733R102 |  | 5203737 | 1991 | SH |  | SOLE |  | 1991 | 0 | 0 |
| MERCK  CO. INC. | Common Stock | 58933Y105 |  | 2282651 | 28588 | SH |  | SOLE |  | 28588 | 0 | 0 |
| MERSANA THERAPEUTICS INC | Common Stock | 59045L106 |  | 7409 | 25032 | SH |  | SOLE |  | 25032 | 0 | 0 |
| MERUS NV | Common Stock | N5749R100 |  | 731193 | 13901 | SH |  | SOLE |  | 13901 | 0 | 0 |
| MESOBLAST LTD- SPON ADR | ADR | 590717401 |  | 99360 | 9124 | SH |  | SOLE |  | 9124 | 0 | 0 |
| META PLATFORMS INC-CLASS A | Common Stock | 30303M102 |  | 35254131 | 47764 | SH |  | SOLE |  | 47764 | 0 | 0 |
| MICROCHIP TECHNOLOGY INC | Common Stock | 595017104 |  | 861821 | 12247 | SH |  | SOLE |  | 12247 | 0 | 0 |
| MICRON TECHNOLOGY INC | Common Stock | 595112103 |  | 3127346 | 25374 | SH |  | SOLE |  | 25374 | 0 | 0 |
| MICROSOFT CORP | Common Stock | 594918104 |  | 70132323 | 140995 | SH |  | SOLE |  | 140995 | 0 | 0 |
| MICROSTRATEGY INC-CL A | Common Stock | 594972408 |  | 2329173 | 5762 | SH |  | SOLE |  | 5762 | 0 | 0 |
| MIND MEDICINE MINDMED INC | Common Stock | 60255C885 |  | 98486 | 15175 | SH |  | SOLE |  | 15175 | 0 | 0 |
| MINERALYS THERAPEUTICS INC | Common Stock | 603170101 |  | 177108 | 13090 | SH |  | SOLE |  | 13090 | 0 | 0 |
| MIRUM PHARMACEUTICALS INC | Common Stock | 604749101 |  | 506305 | 9949 | SH |  | SOLE |  | 9949 | 0 | 0 |
| MODERNA INC | Common Stock | 60770K107 |  | 2143081 | 77676 | SH |  | SOLE |  | 77676 | 0 | 0 |
| MONDAY.COM LTD | Common Stock | M7S64H106 |  | 2673080 | 8500 | SH |  | SOLE |  | 8500 | 0 | 0 |
| MONDELEZ INTERNATIONAL INC-A | Common Stock | 609207105 |  | 1995036 | 29398 | SH |  | SOLE |  | 29398 | 0 | 0 |
| MONSTER BEVERAGE CORP | Common Stock | 61174X109 |  | 1387038 | 22143 | SH |  | SOLE |  | 22143 | 0 | 0 |
| MONTE ROSA THERAPEUTICS INC | Common Stock | 61225M102 |  | 145917 | 32354 | SH |  | SOLE |  | 32354 | 0 | 0 |
| NATERA INC | Common Stock | 632307104 |  | 168940 | 1000 | SH |  | SOLE |  | 1000 | 0 | 0 |
| NETEASE INC-ADR | ADR | 64110W102 |  | 3512538 | 26100 | SH |  | SOLE |  | 26100 | 0 | 0 |
| NETFLIX INC | Common Stock | 64110L106 |  | 25077888 | 18727 | SH |  | SOLE |  | 18727 | 0 | 0 |
| NEUMORA THERAPEUTICS INC | Common Stock | 640979100 |  | 23822 | 32486 | SH |  | SOLE |  | 32486 | 0 | 0 |
| NEUROCRINE BIOSCIENCES INC | Common Stock | 64125C109 |  | 2498340 | 19877 | SH |  | SOLE |  | 19877 | 0 | 0 |
| NEUROGENE INC | Common Stock | 64135M105 |  | 42817 | 2864 | SH |  | SOLE |  | 2864 | 0 | 0 |
| NEWAMSTERDAM PHARMA CO NV | Common Stock | N62509109 |  | 408362 | 22549 | SH |  | SOLE |  | 22549 | 0 | 0 |
| NIKE INC -CL B | Common Stock | 654106103 |  | 765265 | 10718 | SH |  | SOLE |  | 10718 | 0 | 0 |
| NKARTA INC | Common Stock | 65487U108 |  | 23658 | 14252 | SH |  | SOLE |  | 14252 | 0 | 0 |
| NOVARTIS AG-SPONSORED ADR | ADR | 66987V109 |  | 1815150 | 15000 | SH |  | SOLE |  | 15000 | 0 | 0 |
| NOVAVAX INC | Common Stock | 670002401 |  | 204945 | 32531 | SH |  | SOLE |  | 32531 | 0 | 0 |
| NOVOCURE LTD | Common Stock | G6674U108 |  | 398560 | 22391 | SH |  | SOLE |  | 22391 | 0 | 0 |
| NURIX THERAPEUTICS INC | Common Stock | 67080M103 |  | 174404 | 15312 | SH |  | SOLE |  | 15312 | 0 | 0 |
| NUVALENT INC-A | Common Stock | 670703107 |  | 1017155 | 13331 | SH |  | SOLE |  | 13331 | 0 | 0 |
| NVIDIA CORP | Common Stock | 67066G104 |  | 66782607 | 422674 | SH |  | SOLE |  | 422674 | 0 | 0 |
| NXP SEMICONDUCTORS NV | Common Stock | N6596X109 |  | 1258284 | 5736 | SH |  | SOLE |  | 5736 | 0 | 0 |
| OCULAR THERAPEUTIX INC | Common Stock | 67576A100 |  | 575314 | 61995 | SH |  | SOLE |  | 61995 | 0 | 0 |
| OLD DOMINION FREIGHT LINE | Common Stock | 679580100 |  | 778715 | 4798 | SH |  | SOLE |  | 4798 | 0 | 0 |
| OLEMA PHARMACEUTICALS INC | Common Stock | 68062P106 |  | 58541 | 13742 | SH |  | SOLE |  | 13742 | 0 | 0 |
| OMEROS CORP | Common Stock | 682143102 |  | 35304 | 11768 | SH |  | SOLE |  | 11768 | 0 | 0 |
| OMNIAB INC | Common Stock | 68218J103 |  | 42754 | 24571 | SH |  | SOLE |  | 24571 | 0 | 0 |
| ON SEMICONDUCTOR | Common Stock | 682189105 |  | 628291 | 11988 | SH |  | SOLE |  | 11988 | 0 | 0 |
| ONKURE THERAPEUTICS INC-A | Common Stock | 68277Q105 |  | 6157 | 2576 | SH |  | SOLE |  | 2576 | 0 | 0 |
| ORACLE CORP | Common Stock | 68389X105 |  | 4359919 | 19942 | SH |  | SOLE |  | 19942 | 0 | 0 |
| O'REILLY AUTOMOTIVE INC | Common Stock | 67103H107 |  | 1749333 | 19409 | SH |  | SOLE |  | 19409 | 0 | 0 |
| ORIC PHARMACEUTICALS INC | Common Stock | 68622P109 |  | 144922 | 14278 | SH |  | SOLE |  | 14278 | 0 | 0 |
| ORUKA THERAPEUTICS INC | Common Stock | 687604108 |  | 84299 | 7520 | SH |  | SOLE |  | 7520 | 0 | 0 |
| PACCAR INC | Common Stock | 693718108 |  | 1133020 | 11919 | SH |  | SOLE |  | 11919 | 0 | 0 |
| PACIFIC BIOSCIENCES OF CALIF | Common Stock | 69404D108 |  | 77116 | 62190 | SH |  | SOLE |  | 62190 | 0 | 0 |
| PACIRA BIOSCIENCES INC | Common Stock | 695127100 |  | 222270 | 9300 | SH |  | SOLE |  | 9300 | 0 | 0 |
| PALANTIR TECHNOLOGIES INC-A | Common Stock | 69608A108 |  | 10863204 | 79689 | SH |  | SOLE |  | 79689 | 0 | 0 |
| PALO ALTO NETWORKS INC | Common Stock | 697435105 |  | 6945277 | 33939 | SH |  | SOLE |  | 33939 | 0 | 0 |
| PAYCHEX INC | Common Stock | 704326107 |  | 1189572 | 8178 | SH |  | SOLE |  | 8178 | 0 | 0 |
| PAYPAL HOLDINGS INC | Common Stock | 70450Y103 |  | 1641060 | 22081 | SH |  | SOLE |  | 22081 | 0 | 0 |
| PDD HOLDINGS INC | ADR | 722304102 |  | 1587169 | 15165 | SH |  | SOLE |  | 15165 | 0 | 0 |
| PEPGEN INC | Common Stock | 713317105 |  | 7295 | 6572 | SH |  | SOLE |  | 6572 | 0 | 0 |
| PEPSICO INC | Common Stock | 713448108 |  | 4728352 | 35810 | SH |  | SOLE |  | 35810 | 0 | 0 |
| PERSONALIS INC | Common Stock | 71535D106 |  | 116374 | 17740 | SH |  | SOLE |  | 17740 | 0 | 0 |
| PHATHOM PHARMACEUTICALS INC | Common Stock | 71722W107 |  | 134471 | 14022 | SH |  | SOLE |  | 14022 | 0 | 0 |
| PHIBRO ANIMAL HEALTH CORP-A | Common Stock | 71742Q106 |  | 104484 | 4091 | SH |  | SOLE |  | 4091 | 0 | 0 |
| PHILIP MORRIS INTERNATIONAL | Common Stock | 718172109 |  | 973929 | 5312 | SH |  | SOLE |  | 5312 | 0 | 0 |
| PLIANT THERAPEUTICS INC | Common Stock | 729139105 |  | 14302 | 12329 | SH |  | SOLE |  | 12329 | 0 | 0 |
| PRAXIS PRECISION MEDICINES I | Common Stock | 74006W207 |  | 172027 | 4091 | SH |  | SOLE |  | 4091 | 0 | 0 |
| PRECIGEN INC | Common Stock | 74017N105 |  | 84186 | 59286 | SH |  | SOLE |  | 59286 | 0 | 0 |
| PRIME MEDICINE INC | Common Stock | 74168J101 |  | 65134 | 26370 | SH |  | SOLE |  | 26370 | 0 | 0 |
| PROCEPT BIOROBOTICS CORP | Common Stock | 74276L105 |  | 576000 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| PROCTER  GAMBLE CO/THE | Common Stock | 742718109 |  | 1281729 | 8045 | SH |  | SOLE |  | 8045 | 0 | 0 |
| PROSHARES ULTRA GOLD | ETP | 74347W601 |  | 2176648 | 62800 | SH |  | SOLE |  | 62800 | 0 | 0 |
| PROTAGONIST THERAPEUTICS INC | Common Stock | 74366E102 |  | 1045045 | 18908 | SH |  | SOLE |  | 18908 | 0 | 0 |
| PROTHENA CORP PLC | Common Stock | G72800108 |  | 65623 | 10811 | SH |  | SOLE |  | 10811 | 0 | 0 |
| PTC THERAPEUTICS INC | Common Stock | 69366J200 |  | 777435 | 15918 | SH |  | SOLE |  | 15918 | 0 | 0 |
| PULSE BIOSCIENCES INC | Common Stock | 74587B101 |  | 75450 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| PYXIS ONCOLOGY INC | Common Stock | 747324101 |  | 13686 | 12442 | SH |  | SOLE |  | 12442 | 0 | 0 |
| Q32 BIO INC | Common Stock | 746964105 |  | 3651 | 2450 | SH |  | SOLE |  | 2450 | 0 | 0 |
| QUALCOMM INC | Common Stock | 747525103 |  | 4890078 | 30705 | SH |  | SOLE |  | 30705 | 0 | 0 |
| QUANTERIX CORP | Common Stock | 74766Q101 |  | 12595 | 1894 | SH |  | SOLE |  | 1894 | 0 | 0 |
| RAPPORT THERAPEUTICS INC | Common Stock | 75383L102 |  | 83342 | 7330 | SH |  | SOLE |  | 7330 | 0 | 0 |
| RECURSION PHARMACEUTICALS-A | Common Stock | 75629V104 |  | 406161 | 80269 | SH |  | SOLE |  | 80269 | 0 | 0 |
| REGENERON PHARMACEUTICALS | Common Stock | 75886F107 |  | 12881925 | 24537 | SH |  | SOLE |  | 24537 | 0 | 0 |
| REGENXBIO INC | Common Stock | 75901B107 |  | 82716 | 10075 | SH |  | SOLE |  | 10075 | 0 | 0 |
| RELAY THERAPEUTICS INC | Common Stock | 75943R102 |  | 119142 | 34434 | SH |  | SOLE |  | 34434 | 0 | 0 |
| REPLIGEN CORP | Common Stock | 759916109 |  | 14304 | 115 | SH |  | SOLE |  | 115 | 0 | 0 |
| REPLIMUNE GROUP INC | Common Stock | 76029N106 |  | 143837 | 15483 | SH |  | SOLE |  | 15483 | 0 | 0 |
| REVOLUTION MEDICINES INC | Common Stock | 76155X100 |  | 2847951 | 77411 | SH |  | SOLE |  | 77411 | 0 | 0 |
| RHYTHM PHARMACEUTICALS INC | Common Stock | 76243J105 |  | 807442 | 12778 | SH |  | SOLE |  | 12778 | 0 | 0 |
| RIGEL PHARMACEUTICALS INC | Common Stock | 766559702 |  | 67241 | 3590 | SH |  | SOLE |  | 3590 | 0 | 0 |
| ROBLOX CORP -CLASS A | Common Stock | 771049103 |  | 1735800 | 16500 | SH |  | SOLE |  | 16500 | 0 | 0 |
| ROCKET PHARMACEUTICALS INC | Common Stock | 77313F106 |  | 53016 | 21639 | SH |  | SOLE |  | 21639 | 0 | 0 |
| ROIVANT SCIENCES LTD | Common Stock | G76279101 |  | 1538761 | 136536 | SH |  | SOLE |  | 136536 | 0 | 0 |
| ROPER TECHNOLOGIES INC | Common Stock | 776696106 |  | 1383656 | 2441 | SH |  | SOLE |  | 2441 | 0 | 0 |
| ROSS STORES INC | Common Stock | 778296103 |  | 952512 | 7466 | SH |  | SOLE |  | 7466 | 0 | 0 |
| ROYAL CARIBBEAN CRUISES LTD | Common Stock | V7780T103 |  | 3210153 | 10227 | SH |  | SOLE |  | 10227 | 0 | 0 |
| ROYALTY PHARMA PLC- CL A | Common Stock | G7709Q104 |  | 3049255 | 84631 | SH |  | SOLE |  | 84631 | 0 | 0 |
| RUBRIK INC-A | Common Stock | 781154109 |  | 761515 | 8500 | SH |  | SOLE |  | 8500 | 0 | 0 |
| SAGE THERAPEUTICS INC | Common Stock | 78667J108 |  | 114702 | 12577 | SH |  | SOLE |  | 12577 | 0 | 0 |
| SALESFORCE INC | Common Stock | 79466L302 |  | 2015355 | 7380 | SH |  | SOLE |  | 7380 | 0 | 0 |
| SANA BIOTECHNOLOGY INC | Common Stock | 799566104 |  | 123674 | 45302 | SH |  | SOLE |  | 45302 | 0 | 0 |
| SANOFI-ADR | ADR | 80105N105 |  | 3348414 | 69311 | SH |  | SOLE |  | 69311 | 0 | 0 |
| SAP SE-SPONSORED ADR | ADR | 803054204 |  | 5078470 | 16700 | SH |  | SOLE |  | 16700 | 0 | 0 |
| SAREPTA THERAPEUTICS INC | Common Stock | 803607100 |  | 337537 | 19739 | SH |  | SOLE |  | 19739 | 0 | 0 |
| SAVARA INC | Common Stock | 805111101 |  | 79148 | 34714 | SH |  | SOLE |  | 34714 | 0 | 0 |
| SCHOLAR ROCK HOLDING CORP | Common Stock | 80706P103 |  | 675424 | 19069 | SH |  | SOLE |  | 19069 | 0 | 0 |
| SCPHARMACEUTICALS INC | Common Stock | 810648105 |  | 40397 | 10603 | SH |  | SOLE |  | 10603 | 0 | 0 |
| SEA LTD-ADR | ADR | 81141R100 |  | 4462326 | 27900 | SH |  | SOLE |  | 27900 | 0 | 0 |
| SERVICENOW INC | Common Stock | 81762P102 |  | 5002637 | 4866 | SH |  | SOLE |  | 4866 | 0 | 0 |
| SHOPIFY INC - CLASS A | Common Stock | 82509L107 |  | 4309130 | 37357 | SH |  | SOLE |  | 37357 | 0 | 0 |
| SIGA TECHNOLOGIES INC | Common Stock | 826917106 |  | 93555 | 14349 | SH |  | SOLE |  | 14349 | 0 | 0 |
| SILENCE THERAPEUTICS PLC-ADR | ADR | 82686Q101 |  | 54787 | 9446 | SH |  | SOLE |  | 9446 | 0 | 0 |
| SNOWFLAKE INC | Common Stock | 833445109 |  | 827949 | 3700 | SH |  | SOLE |  | 3700 | 0 | 0 |
| SOLID BIOSCIENCES INC | Common Stock | 83422E204 |  | 75821 | 15569 | SH |  | SOLE |  | 15569 | 0 | 0 |
| SPDR GOLD MINISHARES TRUST | ETP | 98149E303 |  | 12396384 | 189200 | SH |  | SOLE |  | 189200 | 0 | 0 |
| SPDR GOLD SHARES | ETP | 78463V107 |  | 8879698 | 29130 | SH |  | SOLE |  | 29130 | 0 | 0 |
| SPDR S 500 ETF TRUST | ETP | 78462F103 |  | 182678 | 295 | SH |  | SOLE |  | 295 | 0 | 0 |
| SPDR S BIOTECH ETF | ETP | 78464A870 |  | 42128 | 508 | SH |  | SOLE |  | 508 | 0 | 0 |
| SPDR S DIVIDEND ETF | ETP | 78464A763 |  | 10180 | 75 | SH |  | SOLE |  | 75 | 0 | 0 |
| SPOTIFY TECHNOLOGY SA | Common Stock | L8681T102 |  | 3491397 | 4550 | SH |  | SOLE |  | 4550 | 0 | 0 |
| SPYRE THERAPEUTICS INC | Common Stock | 00773J202 |  | 181466 | 12122 | SH |  | SOLE |  | 12122 | 0 | 0 |
| STARBUCKS CORP | Common Stock | 855244109 |  | 2373034 | 25898 | SH |  | SOLE |  | 25898 | 0 | 0 |
| STOKE THERAPEUTICS INC | Common Stock | 86150R107 |  | 124464 | 10966 | SH |  | SOLE |  | 10966 | 0 | 0 |
| STRUCTURE THERAPEUTICS INC | ADR | 86366E106 |  | 248196 | 11967 | SH |  | SOLE |  | 11967 | 0 | 0 |
| SUMMIT THERAPEUTICS INC | Common Stock | 86627T108 |  | 3174167 | 149162 | SH |  | SOLE |  | 149162 | 0 | 0 |
| SUPERNUS PHARMACEUTICALS INC | Common Stock | 868459108 |  | 669642 | 21245 | SH |  | SOLE |  | 21245 | 0 | 0 |
| SUTRO BIOPHARMA INC | Common Stock | 869367102 |  | 12111 | 16964 | SH |  | SOLE |  | 16964 | 0 | 0 |
| SYNDAX PHARMACEUTICALS INC | Common Stock | 87164F105 |  | 161846 | 17282 | SH |  | SOLE |  | 17282 | 0 | 0 |
| SYNOPSYS INC | Common Stock | 871607107 |  | 4625912 | 9023 | SH |  | SOLE |  | 9023 | 0 | 0 |
| TAIWAN SEMICONDUCTOR-SP ADR | ADR | 874039100 |  | 7534073 | 33184 | SH |  | SOLE |  | 33184 | 0 | 0 |
| TAKE-TWO INTERACTIVE SOFTWRE | Common Stock | 874054109 |  | 1004428 | 4136 | SH |  | SOLE |  | 4136 | 0 | 0 |
| TAL EDUCATION GROUP- ADR | ADR | 874080104 |  | 607068 | 59400 | SH |  | SOLE |  | 59400 | 0 | 0 |
| TANGO THERAPEUTICS INC | Common Stock | 87583X109 |  | 111468 | 21771 | SH |  | SOLE |  | 21771 | 0 | 0 |
| TAPESTRY INC | Common Stock | 876030107 |  | 2129656 | 24253 | SH |  | SOLE |  | 24253 | 0 | 0 |
| TARSUS PHARMACEUTICALS INC | Common Stock | 87650L103 |  | 341823 | 8438 | SH |  | SOLE |  | 8438 | 0 | 0 |
| TAYSHA GENE THERAPIES INC | Common Stock | 877619106 |  | 121337 | 52527 | SH |  | SOLE |  | 52527 | 0 | 0 |
| TECTONIC THERAPEUTIC INC | Common Stock | 878972108 |  | 74513 | 3750 | SH |  | SOLE |  | 3750 | 0 | 0 |
| TEMPUS AI INC | Common Stock | 88023B103 |  | 2144920 | 33757 | SH |  | SOLE |  | 33757 | 0 | 0 |
| TENCENT MUSIC ENTERTAINM-ADR | ADR | 88034P109 |  | 1656650 | 85000 | SH |  | SOLE |  | 85000 | 0 | 0 |
| TENET HEALTHCARE CORP | Common Stock | 88033G407 |  | 1584000 | 9000 | SH |  | SOLE |  | 9000 | 0 | 0 |
| TERNS PHARMACEUTICALS INC | Common Stock | 880881107 |  | 65428 | 17541 | SH |  | SOLE |  | 17541 | 0 | 0 |
| TESLA INC | Common Stock | 88160R101 |  | 14157789 | 44569 | SH |  | SOLE |  | 44569 | 0 | 0 |
| TEVOGEN BIO HOLDINGS INC | Common Stock | 88165K101 |  | 46168 | 36934 | SH |  | SOLE |  | 36934 | 0 | 0 |
| TEXAS INSTRUMENTS INC | Common Stock | 882508104 |  | 4282578 | 20627 | SH |  | SOLE |  | 20627 | 0 | 0 |
| THERAVANCE BIOPHARMA INC | Common Stock | G8807B106 |  | 110774 | 10043 | SH |  | SOLE |  | 10043 | 0 | 0 |
| THIRD HARMONIC BIO INC | Common Stock | 88427A107 |  | 49218 | 9064 | SH |  | SOLE |  | 9064 | 0 | 0 |
| TJX COMPANIES INC | Common Stock | 872540109 |  | 613745 | 4970 | SH |  | SOLE |  | 4970 | 0 | 0 |
| T-MOBILE US INC | Common Stock | 872590104 |  | 9072941 | 38080 | SH |  | SOLE |  | 38080 | 0 | 0 |
| TOURMALINE BIO INC | Common Stock | 89157D105 |  | 82492 | 5159 | SH |  | SOLE |  | 5159 | 0 | 0 |
| TRADE DESK INC/THE -CLASS A | Common Stock | 88339J105 |  | 732498 | 10175 | SH |  | SOLE |  | 10175 | 0 | 0 |
| TRAVERE THERAPEUTICS INC | Common Stock | 89422G107 |  | 263973 | 17836 | SH |  | SOLE |  | 17836 | 0 | 0 |
| TREVI THERAPEUTICS INC | Common Stock | 89532M101 |  | 111779 | 20435 | SH |  | SOLE |  | 20435 | 0 | 0 |
| TRIP.COM GROUP LTD-ADR | ADR | 89677Q107 |  | 2023080 | 34500 | SH |  | SOLE |  | 34500 | 0 | 0 |
| TSCAN THERAPEUTICS INC | Common Stock | 89854M101 |  | 15235 | 10507 | SH |  | SOLE |  | 10507 | 0 | 0 |
| TWIST BIOSCIENCE CORP | Common Stock | 90184D100 |  | 442731 | 12034 | SH |  | SOLE |  | 12034 | 0 | 0 |
| TYRA BIOSCIENCES INC | Common Stock | 90240B106 |  | 102217 | 10681 | SH |  | SOLE |  | 10681 | 0 | 0 |
| UBER TECHNOLOGIES INC | Common Stock | 90353T100 |  | 3004260 | 32200 | SH |  | SOLE |  | 32200 | 0 | 0 |
| ULTRAGENYX PHARMACEUTICAL IN | Common Stock | 90400D108 |  | 690404 | 18988 | SH |  | SOLE |  | 18988 | 0 | 0 |
| UNIQURE NV | Common Stock | N90064101 |  | 153284 | 10996 | SH |  | SOLE |  | 10996 | 0 | 0 |
| UNITED THERAPEUTICS CORP | Common Stock | 91307C102 |  | 2603104 | 9059 | SH |  | SOLE |  | 9059 | 0 | 0 |
| UNITEDHEALTH GROUP INC | Common Stock | 91324P102 |  | 1753895 | 5622 | SH |  | SOLE |  | 5622 | 0 | 0 |
| UROGEN PHARMA LTD | Common Stock | M96088105 |  | 126876 | 9261 | SH |  | SOLE |  | 9261 | 0 | 0 |
| VANDA PHARMACEUTICALS INC | Common Stock | 921659108 |  | 55871 | 11837 | SH |  | SOLE |  | 11837 | 0 | 0 |
| VANGUARD INFO TECH ETF | ETP | 92204A702 |  | 26531 | 40 | SH |  | SOLE |  | 40 | 0 | 0 |
| VAXCYTE INC | Common Stock | 92243G108 |  | 1037394 | 31910 | SH |  | SOLE |  | 31910 | 0 | 0 |
| VEEVA SYSTEMS INC-CLASS A | Common Stock | 922475108 |  | 222033 | 771 | SH |  | SOLE |  | 771 | 0 | 0 |
| VERA THERAPEUTICS INC | Common Stock | 92337R101 |  | 301780 | 12809 | SH |  | SOLE |  | 12809 | 0 | 0 |
| VERACYTE INC | Common Stock | 92337F107 |  | 425155 | 15729 | SH |  | SOLE |  | 15729 | 0 | 0 |
| VERICEL CORP | Common Stock | 92346J108 |  | 430223 | 10111 | SH |  | SOLE |  | 10111 | 0 | 0 |
| VERISK ANALYTICS INC | Common Stock | 92345Y106 |  | 990681 | 3176 | SH |  | SOLE |  | 3176 | 0 | 0 |
| VERIZON COMMUNICATIONS INC | Common Stock | 92343V104 |  | 623175 | 14402 | SH |  | SOLE |  | 14402 | 0 | 0 |
| VERONA PHARMA PLC - ADR | ADR | 925050106 |  | 2171651 | 22961 | SH |  | SOLE |  | 22961 | 0 | 0 |
| VERTEX PHARMACEUTICALS INC | Common Stock | 92532F100 |  | 19706778 | 44265 | SH |  | SOLE |  | 44265 | 0 | 0 |
| VERVE THERAPEUTICS INC | Common Stock | 92539P101 |  | 201062 | 17904 | SH |  | SOLE |  | 17904 | 0 | 0 |
| VF CORP | Common Stock | 918204108 |  | 292646 | 24906 | SH |  | SOLE |  | 24906 | 0 | 0 |
| VIATRIS INC | Common Stock | 92556V106 |  | 2105060 | 235729 | SH |  | SOLE |  | 235729 | 0 | 0 |
| VIR BIOTECHNOLOGY INC | Common Stock | 92764N102 |  | 139936 | 27765 | SH |  | SOLE |  | 27765 | 0 | 0 |
| VISA INC-CLASS A SHARES | Common Stock | 92826C839 |  | 11603744 | 32682 | SH |  | SOLE |  | 32682 | 0 | 0 |
| VOYAGER THERAPEUTICS INC | Common Stock | 92915B106 |  | 34565 | 11114 | SH |  | SOLE |  | 11114 | 0 | 0 |
| WALMART INC | Common Stock | 931142103 |  | 1471393 | 15048 | SH |  | SOLE |  | 15048 | 0 | 0 |
| WALT DISNEY CO/THE | Common Stock | 254687106 |  | 768114 | 6170 | SH |  | SOLE |  | 6170 | 0 | 0 |
| WARNER BROS DISCOVERY INC | Common Stock | 934423104 |  | 643743 | 56173 | SH |  | SOLE |  | 56173 | 0 | 0 |
| WAVE LIFE SCIENCES LTD | Common Stock | Y95308105 |  | 606905 | 93370 | SH |  | SOLE |  | 93370 | 0 | 0 |
| WELLS FARGO  CO | Common Stock | 949746101 |  | 891896 | 11132 | SH |  | SOLE |  | 11132 | 0 | 0 |
| WOLFSPEED INC | Common Stock | 977852102 |  | 3988 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| WORKDAY INC-CLASS A | Common Stock | 98138H101 |  | 3420960 | 14254 | SH |  | SOLE |  | 14254 | 0 | 0 |
| XCEL ENERGY INC | Common Stock | 98389B100 |  | 898809 | 13095 | SH |  | SOLE |  | 13095 | 0 | 0 |
| XENCOR INC | Common Stock | 98401F105 |  | 112351 | 14294 | SH |  | SOLE |  | 14294 | 0 | 0 |
| XENON PHARMACEUTICALS INC | Common Stock | 98420N105 |  | 482396 | 15412 | SH |  | SOLE |  | 15412 | 0 | 0 |
| XERIS BIOPHARMA HOLDINGS INC | Common Stock | 98422E103 |  | 150220 | 32167 | SH |  | SOLE |  | 32167 | 0 | 0 |
| XPENG INC - ADR | ADR | 98422D105 |  | 536400 | 30000 | SH |  | SOLE |  | 30000 | 0 | 0 |
| XUNLEI LTD-ADR | ADR | 98419E108 |  | 305775 | 75500 | SH |  | SOLE |  | 75500 | 0 | 0 |
| Y-MABS THERAPEUTICS INC | Common Stock | 984241109 |  | 41027 | 9097 | SH |  | SOLE |  | 9097 | 0 | 0 |
| ZAI LAB LTD-ADR | ADR | 98887Q104 |  | 406596 | 11627 | SH |  | SOLE |  | 11627 | 0 | 0 |
| ZEEKR INTELLIGENT TECHNO-ADR | ADR | 98923K103 |  | 153000 | 6000 | SH |  | SOLE |  | 6000 | 0 | 0 |
| ZETA GLOBAL HOLDINGS CORP-A | Common Stock | 98956A105 |  | 340780 | 22000 | SH |  | SOLE |  | 22000 | 0 | 0 |
| ZEVRA THERAPEUTICS INC | Common Stock | 488445206 |  | 96751 | 10982 | SH |  | SOLE |  | 10982 | 0 | 0 |
| ZOETIS INC | Common Stock | 98978V103 |  | 153767 | 986 | SH |  | SOLE |  | 986 | 0 | 0 |
| ZSCALER INC | Common Stock | 98980G102 |  | 1737658 | 5535 | SH |  | SOLE |  | 5535 | 0 | 0 |
| ZYMEWORKS INC | Common Stock | 98985Y108 |  | 175650 | 13996 | SH |  | SOLE |  | 13996 | 0 | 0 |

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