# EDGAR Filing Document

**Accession Number:** 0001638287
**File Stem:** 0001104659-26-039618
**Filing Date:** 2026-4
**Character Count:** 27447
**Document Hash:** f04de4624a6b700024f50c0b9588207b
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-26-039618.hdr.sgml**: 20260403

**ACCESSION NUMBER**: 0001104659-26-039618

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 14

**FILED AS OF DATE**: 20260403

**DATE AS OF CHANGE**: 20260403

**EFFECTIVENESS DATE**: 20260403

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** MetaVia Inc.
- **CENTRAL INDEX KEY:** 0001638287
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 472389984
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-294877
- **FILM NUMBER:** 26838049

**BUSINESS ADDRESS:**
- **STREET 1:** 545 CONCORD AVENUE
- **STREET 2:** SUITE 210
- **CITY:** CAMBRIDGE
- **STATE:** MA
- **ZIP:** 02138
- **BUSINESS PHONE:** (857) 702-9600

**MAIL ADDRESS:**
- **STREET 1:** 545 CONCORD AVENUE
- **STREET 2:** SUITE 210
- **CITY:** CAMBRIDGE
- **STATE:** MA
- **ZIP:** 02138

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** NeuroBo Pharmaceuticals, Inc.
- **DATE OF NAME CHANGE:** 20191231

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Gemphire Therapeutics Inc.
- **DATE OF NAME CHANGE:** 20150331

**Registration No. 333-**

**As filed with the Securities and Exchange Commission on April 3, 2026** 

**UNITED STATES<br> SECURITIES AND EXCHANGE COMMISSION**<br> **Washington, D.C. 20549**

**FORM S-8**

***REGISTRATION STATEMENT*** ***<br> UNDER<br> THE SECURITIES ACT OF 1933***

**MetaVia** **INC.<br> (Exact name of registrant as specified in its charter)** 

---

| | |
|:---|:---|
| **Delaware** | **47-2389984** |
| (State or other jurisdiction of incorporation or organization) | (IRS Employer Identification Number) |
| **545 Concord Avenue, Suite 210**<br> **Cambridge, MA** | **02138** |
| (Address of Principal Executive Offices) | (Zip code) |

---

**MetaVia Inc. Amended and Restated 2022 Equity Incentive Plan** 

(Full title of the plan)

**Hyung Heon Kim<br> President, Chief Executive Officer and Director<br> MetaVia Inc.** 

**545 Concord Avenue, Suite 210** 

**Cambridge, MA 02138**<br> (Name and address of agent for service)

**857-702-9600** 

(Telephone number, including area code, of agent for service)

***Copies to:***<br> **Phillip D. Torrence, Esq.<br> Joshua W. Damm, Esq.<br> Honigman LLP<br> 650 Trade Centre Way, Suite 200<br> Kalamazoo, Michigan 49002<br> Tel: (269) 337-7700** 

**Fax: (269) 337-7703**

<br> Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ◻ | Accelerated filer | ◻ |
| Non-accelerated filer | ⌧ | Smaller reporting company | ⌧ |
|  |  | Emerging growth company | ◻ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ◻

**REGISTRATION OF ADDITIONAL SHARES PURSUANT TO GENERAL INSTRUCTION E**

This Registration Statement on Form S-8 (the "***Registration Statement***") is being filed by MetaVia Inc. (the "***Registrant***," "***we***," "***us***" or "***our***") for the purpose of registering an additional 94,236 shares of common stock, par value $0.001 per share (the "***Common Stock***"), issuable under the MetaVia Inc. Amended and Restated 2022 Equity Incentive Plan (the "***2022 Incentive Plan***") pursuant to the provision of the 2022 Incentive Plan providing for an annual automatic increase in the number of shares reserved for issuance under the 2022 Incentive Plan. This Registration Statement hereby incorporates by reference the contents of the Registrant's previous registration statements on Form S-8 filed with the Securities and Exchange Commission (the ***"Commission"***) on [April 17, 2023](https://www.sec.gov/Archives/edgar/data/1638287/000155837023006069/tmb-20230417xs8.htm) (Registration No. 333-271292) and [March 27, 2025](https://www.sec.gov/Archives/edgar/data/1638287/000110465925028825/tm259572d1_s8.htm) (Registration No. 333-286184) to the extent not superseded hereby.

**PART I**

**INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS**

The information called for by Part I of Form S-8 is omitted from this Registration Statement in accordance with Rule 428 of the Securities Act of 1933, as amended (the ***"Securities Act"***), and the instructions to Form S-8. In accordance with the rules and regulations of the Commission and the instructions to Form S-8, such documents are not being filed with the Commission either as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424 of the Securities Act. The documents containing the information specified in Part I of Form S-8 will be delivered to the participants in the equity benefit plan covered by this Registration Statement as specified by Rule 428(b)(1) under the Securities Act.

**PART II**

**INFORMATION REQUIRED IN THE REGISTRATION STATEMENT**

**Item 3. Incorporation of Documents by Reference**.

The following documents filed by the Registrant with the Commission pursuant to the Securities Act and the Securities Exchange Act of 1934, as amended (the ***"Exchange Act"***), are incorporated herein by reference:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the Registrant's Annual Report on [Form 10-K for the fiscal year ended December 31, 2025, filed with the Commission on March 26, 2026](https://www.sec.gov/ix?doc=/Archives/edgar/data/1638287/000110465926034911/mtva-20251231x10k.htm) (the  ***"Annual Report"***);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) all other
 reports filed pursuant to Section 13(a) or 15(d) of the Exchange Act since
 the end of the fiscal year covered by the Registrant's Annual Report referred to in
 (a) above; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) the description of the Registrant's
Common Stock which is contained in the Registration Statement on Form 8-A filed with the Commission
on [June 20, 2016](https://www.sec.gov/Archives/edgar/data/1638287/000110465916128353/a15-18801_108a12b.htm) (File
No. 001-37809) under Section 12(b) of the Exchange Act, including any amendment or report filed for the purpose of updating such description.

All documents subsequently filed by the Registrant with the Commission pursuant to Sections 13(a), 13(c), 14, or 15(d) of the Exchange Act, prior to the filing of a post-effective amendment to the Registration Statement which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference into this Registration Statement and to be a part hereof from the date of the filing of such documents, except that information furnished to the Commission under Item 2.02 or Item 7.01 in Current Reports on Form 8-K and any exhibit relating to such information, shall not be deemed to be incorporated by reference in this Registration Statement.

Any statement contained herein or in a document incorporated or deemed to be incorporated by reference in this Registration Statement shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained in this Registration Statement, or in any other subsequently filed document which also is or is deemed to be incorporated by reference in this Registration Statement, modifies or supersedes such earlier statement. Any statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.

**Item 8. Exhibits**.

**EXHIBIT INDEX**

The following exhibits are filed as part of this Registration Statement.

**INDEX TO** **EXHIBITS**

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | | **Incorporated by Reference** | **Incorporated by Reference** | **Incorporated by Reference** | **Incorporated by Reference** |
| **Exhibit**<br>**Number** | <br>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**Description** | **Form** | &nbsp;&nbsp;**File No.** | **Exhibit** | **Filing Date** |
| &nbsp;&nbsp;[3.1](https://www.sec.gov/Archives/edgar/data/1638287/000110465916138639/a16-16524_1ex3d1.htm) | [Third Amended and Restated Certificate of Incorporation of the Registrant](https://www.sec.gov/Archives/edgar/data/1638287/000110465916138639/a16-16524_1ex3d1.htm) | [8-K](https://www.sec.gov/Archives/edgar/data/1638287/000110465916138639/a16-16524_1ex3d1.htm) | [001-37809](https://www.sec.gov/Archives/edgar/data/1638287/000110465916138639/a16-16524_1ex3d1.htm) | [3.1](https://www.sec.gov/Archives/edgar/data/1638287/000110465916138639/a16-16524_1ex3d1.htm) | [8/10/2016](https://www.sec.gov/Archives/edgar/data/1638287/000110465916138639/a16-16524_1ex3d1.htm) |
| &nbsp;&nbsp;[3.2](https://www.sec.gov/Archives/edgar/data/1638287/000110465919076916/a19-28294_1ex3d1.htm) | [Certificate of Amendment (Reverse Stock Split) to the Third Amended and Restated Certificate of Incorporation of the Registrant](https://www.sec.gov/Archives/edgar/data/1638287/000110465919076916/a19-28294_1ex3d1.htm) | [8-K](https://www.sec.gov/Archives/edgar/data/1638287/000110465919076916/a19-28294_1ex3d1.htm) | [001-37809](https://www.sec.gov/Archives/edgar/data/1638287/000110465919076916/a19-28294_1ex3d1.htm) | [3.1](https://www.sec.gov/Archives/edgar/data/1638287/000110465919076916/a19-28294_1ex3d1.htm) | [12/31/2019](https://www.sec.gov/Archives/edgar/data/1638287/000110465919076916/a19-28294_1ex3d1.htm) |
| &nbsp;&nbsp;[3.3](https://www.sec.gov/Archives/edgar/data/1638287/000110465919076916/a19-28294_1ex3d2.htm) | [Certificate of Amendment (Name Change) to the Third Amended and Restated Certificate of Incorporation of the Registrant](https://www.sec.gov/Archives/edgar/data/1638287/000110465919076916/a19-28294_1ex3d2.htm) | [8-K](https://www.sec.gov/Archives/edgar/data/1638287/000110465919076916/a19-28294_1ex3d2.htm) | [001-37809](https://www.sec.gov/Archives/edgar/data/1638287/000110465919076916/a19-28294_1ex3d2.htm) | [3.2](https://www.sec.gov/Archives/edgar/data/1638287/000110465919076916/a19-28294_1ex3d2.htm) | [12/31/2019](https://www.sec.gov/Archives/edgar/data/1638287/000110465919076916/a19-28294_1ex3d2.htm) |
| &nbsp;&nbsp;[3.4](https://www.sec.gov/Archives/edgar/data/1638287/000155837022014321/nrbo-20220912xex3d1.htm) | [Certificate of Amendment (Reverse Stock Split) to the Third Amended and Restated Certificate of Incorporation of the Registrant](https://www.sec.gov/Archives/edgar/data/1638287/000155837022014321/nrbo-20220912xex3d1.htm) | [8-K](https://www.sec.gov/Archives/edgar/data/1638287/000155837022014321/nrbo-20220912xex3d1.htm) | [001-37809](https://www.sec.gov/Archives/edgar/data/1638287/000155837022014321/nrbo-20220912xex3d1.htm) | [3.1](https://www.sec.gov/Archives/edgar/data/1638287/000155837022014321/nrbo-20220912xex3d1.htm) | [9/12/2022](https://www.sec.gov/Archives/edgar/data/1638287/000155837022014321/nrbo-20220912xex3d1.htm) |
| &nbsp;&nbsp;[3.5](https://www.sec.gov/Archives/edgar/data/1638287/000155837023019894/nrbo-20231219xex3d1.htm) | [Certificate of Amendment to the Third Amended and Restated Certificate of Incorporation of the Registrant](https://www.sec.gov/Archives/edgar/data/1638287/000155837023019894/nrbo-20231219xex3d1.htm) | [8-K](https://www.sec.gov/Archives/edgar/data/1638287/000155837023019894/nrbo-20231219xex3d1.htm) | [001-37809](https://www.sec.gov/Archives/edgar/data/1638287/000155837023019894/nrbo-20231219xex3d1.htm) | [3.1](https://www.sec.gov/Archives/edgar/data/1638287/000155837023019894/nrbo-20231219xex3d1.htm) | [12/19/2023](https://www.sec.gov/Archives/edgar/data/1638287/000155837023019894/nrbo-20231219xex3d1.htm) |
| &nbsp;&nbsp;[3.6](https://www.sec.gov/Archives/edgar/data/1638287/000155837024015839/nrbo-20241115xex3d1.htm) | [Certificate of Amendment (Name Change) to the Third Amended and Restated Certificate of Incorporation of the Registrant](https://www.sec.gov/Archives/edgar/data/1638287/000155837024015839/nrbo-20241115xex3d1.htm) | [8-K](https://www.sec.gov/Archives/edgar/data/1638287/000155837024015839/nrbo-20241115xex3d1.htm) | [001-37809](https://www.sec.gov/Archives/edgar/data/1638287/000155837024015839/nrbo-20241115xex3d1.htm) | [3.1](https://www.sec.gov/Archives/edgar/data/1638287/000155837024015839/nrbo-20241115xex3d1.htm) | [11/18/2024](https://www.sec.gov/Archives/edgar/data/1638287/000155837024015839/nrbo-20241115xex3d1.htm) |
| &nbsp;&nbsp;[3.7](https://www.sec.gov/Archives/edgar/data/1638287/000155837024015839/nrbo-20241115xex3d2.htm) | [Fourth Amended and Restated Bylaws of the Registrant](https://www.sec.gov/Archives/edgar/data/1638287/000155837024015839/nrbo-20241115xex3d2.htm) | [8-K](https://www.sec.gov/Archives/edgar/data/1638287/000155837024015839/nrbo-20241115xex3d2.htm) | [001-37809](https://www.sec.gov/Archives/edgar/data/1638287/000155837024015839/nrbo-20241115xex3d2.htm) | [3.2](https://www.sec.gov/Archives/edgar/data/1638287/000155837024015839/nrbo-20241115xex3d2.htm) | [11/18/2024](https://www.sec.gov/Archives/edgar/data/1638287/000155837024015839/nrbo-20241115xex3d2.htm) |
| &nbsp;&nbsp;[5.1\*](tm269393d2_ex5-1.htm) | [Opinion of Honigman LLP](tm269393d2_ex5-1.htm) |  |  |  |  |
| &nbsp;&nbsp;[23.1\*](tm269393d2_ex23-1.htm) | [Consent of BDO USA, P.C., Independent Registered Public Accounting Firm](tm269393d2_ex23-1.htm) |  |  |  |  |
| &nbsp;&nbsp;[23.2\*](tm269393d2_ex5-1.htm) | [Consent of Honigman LLP (included in Exhibit 5.1)](tm269393d2_ex5-1.htm) |  |  |  |  |
| &nbsp;&nbsp;[24.1\*](#a_001) | [Power of Attorney of certain directors and officers of the Registrant (contained on signature page)](#a_001) |  |  |  |  |
| &nbsp;&nbsp;[99.1](https://www.sec.gov/Archives/edgar/data/1638287/000155837025003386/mtva-20241231xex10d7.htm) | [Amended and Restated 2022 Equity Incentive Plan of the Registrant, as amended November 29, 2024, and forms of award agreements](https://www.sec.gov/Archives/edgar/data/1638287/000155837025003386/mtva-20241231xex10d7.htm) | [10-K](https://www.sec.gov/Archives/edgar/data/1638287/000155837025003386/mtva-20241231xex10d7.htm) | [001-37809](https://www.sec.gov/Archives/edgar/data/1638287/000155837025003386/mtva-20241231xex10d7.htm) | [10.7](https://www.sec.gov/Archives/edgar/data/1638287/000155837025003386/mtva-20241231xex10d7.htm) | [3/20/2025](https://www.sec.gov/Archives/edgar/data/1638287/000155837025003386/mtva-20241231xex10d7.htm) |
| &nbsp;&nbsp;[107\*](tm269393d2_ex-filingfees.htm) | [Filing Fee Table](tm269393d2_ex-filingfees.htm) |  |  |  |  |

---

\* Filed herewith.

**SIGNATURES**

Pursuant to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, hereunto duly authorized, in the City of Cambridge, Commonwealth of Massachusetts, on April 3, 2026.

---

| | | |
|:---|:---|:---|
| **METAVIA INC.** | **METAVIA INC.** | **METAVIA INC.** |
| By: | */s/ Hyung Heon Kim* | */s/ Hyung Heon Kim* |
|  | Name: | Hyung Heon Kim |
|  | Title: | President, Chief Executive Officer and Director |

---

**POWER OF ATTORNEY**

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Hyung Heon Kim and Andrew I. Koven, and each of them, as his true and lawful attorneys-in-fact, proxies and agents, each with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments to this Registration Statement, including post-effective amendments and to file the same, with any exhibits thereto and other documents in connection therewith, with the Commission, or any state securities department or any other federal or state agency or governmental authority granting unto such attorneys-in-fact, proxies and agents full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact, proxies and agents, or their or his substitutes, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons on behalf of the Registrant in the capacities and on the dates indicated.

---

| | | |
|:---|:---|:---|
| **Signature** | **Title** | **Date** |
| */s/ Hyung Heon Kim* | President, Chief Executive Officer (Principal Executive | April 3, 2026 |
| Hyung Heon Kim | Officer) and Director |  |
| */s/ Marshall H. Woodworth* | Chief Financial Officer (Principal Financial Officer and | April 3, 2026 |
| <br> Marshall H. Woodworth | Principal Accounting Officer) |  |
| */s/ Andrew I. Koven* | Chairman of the Board of Directors | April 3, 2026 |
| Andrew I. Koven |  |  |
| */s/ Mark A. Glickman* | Director | April 3, 2026 |
| Mark A. Glickman |  |  |
| */s/ Jason L. Groves*<br>| Director | April 3, 2026 |
| Jason L. Groves |  |  |
| */s/ Michael Salsbury* | Director | April 3, 2026 |
| Michael Salsbury |  |  |
| */s/ D. Gordon Strickland*  | Director | April 3, 2026 |
| D. Gordon Strickland |  |  |
| */s/ James P. Tursi, M.D.* | Director | April 3, 2026 |
| James P. Tursi, M.D. |  |  |

---

## Exhibit 5.1

**Exhibit 5.1**

![](tm269393d2_ex5-1img001.jpg)

April 3, 2026

MetaVia Inc.

545 Concord Avenue, Suite 210

Cambridge, Massachusetts 02138

***Re: Registration Statement on Form S-8***

Ladies and Gentlemen:

We have acted as counsel to MetaVia Inc., a Delaware corporation (the ***"Company"***), in connection with the preparation and filing with the Securities and Exchange Commission (the ***"Commission"***) of a Registration Statement on Form S-8 (the ***"Registration Statement"***) for the registration under the Securities Act of 1933, as amended (the ***"Securities Act"***), of a maximum of 94,236 shares (the ***"Shares"***) of the Company's common stock, par value $0.001 per share (the ***"Common Stock"***), to be issued by the Company pursuant to awards under the MetaVia Inc. Amended and Restated 2022 Equity Incentive Plan (as amended from time to time, the ***"2022 Incentive Plan"***).

We do not express any opinion herein concerning any law other than the Delaware General Corporation Law (the ***"DGCL"***). We are not admitted to practice in the State of Delaware and, with respect to the opinion set forth herein, insofar as it relates to any Delaware law, we have limited our review to standard compilations available to us of the DGCL, which we have assumed to be accurate and complete, and we have not reviewed case law.

In rendering the opinion set forth herein, we have assumed the genuineness of all signatures on all documents examined by us, the due authority of the parties signing such documents, the authenticity of all documents submitted to us as originals, the conformity to authentic originals of all documents submitted to us as copies and that the offer and sale of the Shares complies in all respects with the terms, conditions and restrictions set forth in the Registration Statement and the 2022 Incentive Plan. The Company has represented to us, and we have also assumed, that the Company has reserved from its duly authorized capital stock a sufficient number of shares of Common Stock, including the Shares, for issuance under the 2022 Incentive Plan and will keep such reserve available at all times to enable the Company to issue and deliver the Shares upon the settlement of awards under the 2022 Incentive Plan.

Based upon, subject to and limited by the foregoing, and based upon our examination of such documents and other matters as we deem relevant, we are of the opinion that the Shares to be issued by the Company under the 2022 Incentive Plan pursuant to the Registration Statement are duly authorized and, when issued and sold by the Company in accordance with the 2022 Incentive Plan and the awards thereunder, the Registration Statement and the related prospectus, will be validly issued, fully paid and non-assessable.

This opinion letter speaks only as of its date. We do not undertake any obligation to advise you or any other party of changes of law or fact that occur after the date of this opinion letter – even though the change may affect the legal analysis or legal conclusion in this opinion letter.

We hereby consent to the filing of this opinion with the Commission as Exhibit 5.1 to the Registration Statement. In giving such consent, we do not admit that we are within the category of persons whose consent is required by Section 7 of the Securities Act or the rules and regulations promulgated thereunder by the Commission.

---

| |
|:---|
| Very truly yours, |
| /s/ Honigman LLP |
| HONIGMAN LLP |

---

&nbsp;&nbsp;**Honigman LLP • 650 Trade Centre Way • Suite 200 • Kalamazoo, Michigan 49002-0402**

## Exhibit 23.1

**Exhibit 23.1**

<u>Consent of Independent Registered Public Accounting Firm</u>

We hereby consent to the incorporation by reference in this Registration Statement of our report dated March 26, 2026, relating to the consolidated financial statements of MetaVia Inc. (the Company) appearing in the Company's Annual Report on Form 10-K for the year ended December 31, 2025. Our report contains an explanatory paragraph regarding the Company's ability to continue as a going concern.

/s/ BDO USA, P.C.

Boston, Massachusetts

April 3, 2026

## Ex-Filing

?xml version='1.0' encoding='ASCII'? EX-FILING FEES

**Exhibit 107**

---

| |
|:---|
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Calculation of Filing Fee Tables**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **S-8**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **MetaVia Inc.**  |

---

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| | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Security Type**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Security Class Title**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Fee Calculation Rule**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Amount Registered**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Proposed Maximum Offering Price Per Unit**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Maximum Aggregate Offering Price**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Fee Rate**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Amount of Registration Fee**  |
| 1 | Equity | Common Stock, par value $0.001 per share | Other | 94236 | $1.2747 | $120122.63 | 0.0001381 | $16.59 |
| Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: |  | $120122.63  |  | $16.59  |
| Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  |  |  |  | $0.00  |
| Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  |  |  |  | $16.59  |

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Offering Note** <br>

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <sup>1</sup> 1a. Pursuant to Rule 416(a) promulgated under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement on Form S-8 (the "Registration Statement") shall also cover any additional shares of common stock, par value $0.001 per share (the "Common Stock"), that become issuable under the plan set forth herein by reason of any stock dividend, stock split, recapitalization, or other similar transaction effected that results in an increase to the number of outstanding shares of MetaVia Inc. (the "Registrant") Common Stock. 1b. Represents additional shares of Common Stock to be registered and available for grant under the Registrant's Amended and Restated 2022 Equity Incentive Plan (the "2022 Incentive Plan") resulting from the annual automatic increase in shares available for issuance under the 2022 Incentive Plan pursuant to the provision of the 2022 Incentive Plan providing for an annual automatic increase in the number of shares reserved for issuance under the 2022 Incentive Plan. 1c. Estimated pursuant to Rules 457(c) and 457(h) under the Securities Act, solely for the purposes of calculating the registration fee and based on the average of the high and low prices of the Registrant's Common Stock as reported on the Nasdaq Capital Market on March 27, 2026, which date is within five business days prior to the filing of this Registration Statement. 1d. The Registrant does not have any fee offsets.

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| **Rule 457(p)** |
| Fee Offset Claims |
| Fee Offset Sources |

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