# EDGAR Filing Document

**Accession Number:** 0000872625
**File Stem:** 0002071691-25-001647
**Filing Date:** 2025-9
**Character Count:** 37565
**Document Hash:** 66ae060937fa70efd4aedb6e541bfce7
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0002071691-25-001647.hdr.sgml**: 20250923

**ACCESSION NUMBER**: 0002071691-25-001647

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20250731

**FILED AS OF DATE**: 20250923

**DATE AS OF CHANGE**: 20250923

**PERIOD START**: 20260430

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** FRANKLIN STRATEGIC SERIES
- **CENTRAL INDEX KEY:** 0000872625

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** FL
- **FISCAL YEAR END:** 0430

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-06243
- **FILM NUMBER:** 251333250

**BUSINESS ADDRESS:**
- **STREET 1:** ONE FRANKLIN PARKWAY
- **CITY:** SAN MATEO
- **STATE:** CA
- **ZIP:** 94403-1906
- **BUSINESS PHONE:** 650-570-3000

**MAIL ADDRESS:**
- **STREET 1:** ONE FRANKLIN PARKWAY
- **CITY:** SAN MATEO
- **STATE:** CA
- **ZIP:** 94403-1906

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** FRANKLIN CALIFORNIA 250 GROWTH FUND
- **DATE OF NAME CHANGE:** 19911216

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** FRANKLIN CALIFORNIA 250 GROWTH INDEX FUND
- **DATE OF NAME CHANGE:** 19910917

## Series and Classes Contracts Data

### FRANKLIN BIOTECHNOLOGY DISCOVERY FUND (Series ID: S000006882)

| Class ID   | Class Name    | Ticker Symbol   |
|:---|:---|:---|
| C000018631 | CLASS A       | FBDIX           |
| C000081539 | ADVISOR CLASS | FTDZX           |
| C000128862 | Class R6      | FRBRX           |
| C000141458 | Class C       | FBTDX           |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** Franklin Strategic Series

- **b. Investment Company Act file number:** 811-06243

- **c. CIK number of Registrant:** 0000872625

- **d. LEI of Registrant:** 549300NDWC0J6DXVSX36

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** One Franklin Parkway

  - **City:** San Mateo

  - **State:** CA

  - **Foreign country:** US

  - **Zip / Postal Code:** 94403-1906

  - **Telephone number:** 650-312-2000

**Item A.2. Information about the Series.**

- **a. Name of Series:** Franklin Biotechnology Discovery Fund

- **b. EDGAR series identifier (if any):** S000006882

- **c. LEI of Series:** 6N5133EDK315FXQQM036

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2026-04-30

- **b. Date as of which information is reported:** 2025-07-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $749870210.72

**Total Liabilities:** $22930493.04

**Net Assets:** $726939717.68

**Cash Not Reported:** $113.14

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000128862 | -3.29%               | 2.15%                | 9.12%                |
| Class ID C000018631 | -3.33%               | 2.13%                | 9.08%                |
| Class ID C000081539 | -3.30%               | 2.15%                | 9.10%                |
| Class ID C000141458 | -3.38%               | 2.06%                | 9.01%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $-5189998.42             | $-18511789.44                              |
| Month 2  | $5754441.44              | $8923721.28                                |
| Month 3  | $8067181.86              | $53684592.91                               |

### Schedule of Portfolio Investments

| Name                                                   | Title                                                  | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Apogee Therapeutics, Inc.                              | Apogee Therapeutics, Inc.                              | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    110213 | NS      | $4216749.38   | 0.58%             |  |  |  | No            |                  1 | On Loan: No      |
| Solid Biosciences, Inc.                                | Solid Biosciences, Inc.                                | CUSIP: 83422E204<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    566700 | NS      | $3876228.00   | 0.53%             |  |  |  | No            |                  1 | On Loan: No      |
| uniQure NV                                             | uniQure NV                                             | CUSIP: N/A<br>LEI: 724500RPCTZLFYJZ3S98       | Long             | EC               | CORP              | NL        |    568800 | NS      | $7917696.00   | 1.09%             |  |  |  | No            |                  1 | On Loan: No      |
| ORIC Pharmaceuticals, Inc.                             | ORIC Pharmaceuticals, Inc.                             | CUSIP: 68622P109<br>LEI: 54930033FJRNEYBW0L25 | Long             | EC               | CORP              | US        |    363283 | NS      | $3621931.51   | 0.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Merus NV                                               | Merus NV                                               | CUSIP: N/A<br>LEI: 549300W8GPUWU8QNU293       | Long             | EC               | CORP              | NL        |    424998 | NS      | $28151867.52  | 3.87%             |  |  |  | No            |                  1 | On Loan: No      |
| Jazz Pharmaceuticals plc                               | Jazz Pharmaceuticals plc                               | CUSIP: N/A<br>LEI: 635400GAUMJCLEZRRV50       | Long             | EC               | CORP              | IE        |    238229 | NS      | $27308190.27  | 3.76%             |  |  |  | No            |                  1 | On Loan: No      |
| Eli Lilly & Co.                                        | Eli Lilly & Co.                                        | CUSIP: 532457108<br>LEI: FRDRIPF3EKNDJ2CQJL29 | Long             | EC               | CORP              | US        |     14071 | NS      | $10413524.97  | 1.43%             |  |  |  | No            |                  1 | On Loan: No      |
| Mineralys Therapeutics, Inc.                           | Mineralys Therapeutics, Inc.                           | CUSIP: 603170101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    645332 | NS      | $9131447.80   | 1.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences, Inc.                           | Neurocrine Biosciences, Inc.                           | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |    135273 | NS      | $17346056.79  | 2.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Achieve Life Sciences, Inc.                            | Achieve Life Sciences, Inc.                            | CUSIP: N/A<br>LEI: 549300V82ZKZDTAU0A46       | Long             |  | CORP              | US        |    698900 | NS      | $471918.25    | 0.06%             |  |  |  | No            |                  3 | On Loan: No      |
| Insmed, Inc.                                           | Insmed, Inc.                                           | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |    281340 | NS      | $30182155.20  | 4.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Dyne Therapeutics, Inc.                                | Dyne Therapeutics, Inc.                                | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    288652 | NS      | $2843222.20   | 0.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Zealand Pharma A/S                                     | Zealand Pharma A/S, Class A                            | CUSIP: N/A<br>LEI: 549300ITBB1ULBL4CZ12       | Long             | EC               | CORP              | DK        |     69700 | NS      | $3606127.38   | 0.50%             |  |  |  | No            |                  2 | On Loan: No      |
| Soleno Therapeutics, Inc.                              | Soleno Therapeutics, Inc.                              | CUSIP: 834203309<br>LEI: 5493003LCY77N7FXK844 | Long             | EC               | CORP              | US        |     88893 | NS      | $7686577.71   | 1.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Sartorius Stedim Biotech                               | Sartorius Stedim Biotech                               | CUSIP: N/A<br>LEI: 52990006IVXY7GCSSR39       | Long             | EC               | CORP              | FR        |     10100 | NS      | $2018289.62   | 0.28%             |  |  |  | No            |                  2 | On Loan: No      |
| Sartorius AG                                           | Sartorius AG                                           | CUSIP: N/A<br>LEI: 529900EQV2DY4FOAMU38       | Long             | EP               | CORP              | DE        |      9200 | NS      | $1959158.11   | 0.27%             |  |  |  | No            |                  2 | On Loan: No      |
| Benitec Biopharma, Inc.                                | Benitec Biopharma, Inc.                                | CUSIP: 08205P209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1150214 | NS      | $12571839.02  | 1.73%             |  |  |  | No            |                  1 | On Loan: —       |
| Argenx SE                                              | Argenx SE                                              | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |     48212 | NS      | $32317949.96  | 4.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Aura Biosciences, Inc.                                 | Aura Biosciences, Inc.                                 | CUSIP: 05153U107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    820936 | NS      | $5656249.04   | 0.78%             |  |  |  | No            |                  1 | On Loan: —       |
| Olema Pharmaceuticals, Inc.                            | Olema Pharmaceuticals, Inc.                            | CUSIP: 68062P106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     94989 | NS      | $488243.46    | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Revolution Medicines, Inc.                             | Revolution Medicines, Inc.                             | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |    185452 | NS      | $6911796.04   | 0.95%             |  |  |  | No            |                  1 | On Loan: No      |
| Candid, Inc.                                           | Candid, Inc., Series B                                 | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |   1519609 | NS      | $1446801.49   | 0.20%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Contineum Therapeutics, Inc.                           | Contineum Therapeutics, Inc., Class A                  | CUSIP: 21217B100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    302967 | NS      | $1787505.30   | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Engene Holdings, Inc.                                  | Engene Holdings, Inc.                                  | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | CA        |    272359 | NS      | $1032240.61   | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Dianthus Therapeutics, Inc.                            | Dianthus Therapeutics, Inc.                            | CUSIP: 252828108<br>LEI: 549300Z3N6ODPCOFC890 | Long             | EC               | CORP              | US        |     87280 | NS      | $1804077.60   | 0.25%             |  |  |  | No            |                  1 | On Loan: —       |
| Praxis Precision Medicines, Inc.                       | Praxis Precision Medicines, Inc.                       | CUSIP: 74006W207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    113704 | NS      | $6165030.88   | 0.85%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytokinetics, Inc.                                     | Cytokinetics, Inc.                                     | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |     50600 | NS      | $1904584.00   | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Satellos Bioscience, Inc.                              | Satellos Bioscience, Inc.                              | CUSIP: 80401L308<br>LEI: 529900EN243BZ5QC9N39 | Long             | EC               | CORP              | CA        |   1161960 | NS      | $478000.29    | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Day One Biopharmaceuticals, Inc.                       | Day One Biopharmaceuticals, Inc.                       | CUSIP: 23954D109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    851469 | NS      | $5713356.99   | 0.79%             |  |  |  | No            |                  1 | On Loan: No      |
| Janux Therapeutics, Inc.                               | Janux Therapeutics, Inc.                               | CUSIP: 47103J105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    186502 | NS      | $4478845.53   | 0.62%             |  |  |  | No            |                  1 | On Loan: No      |
| Centessa Pharmaceuticals plc                           | Centessa Pharmaceuticals plc                           | CUSIP: 152309100<br>LEI: 213800GIDAARDSKOI827 | Long             | EC               | CORP              | GB        |    489229 | NS      | $8400061.93   | 1.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Lycia LLC                                              | Lycia LLC, Series C                                    | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | JP        |    859370 | NS      | $1488605.87   | 0.20%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Xenon Pharmaceuticals, Inc.                            | Xenon Pharmaceuticals, Inc.                            | CUSIP: 98420N105<br>LEI: 549300XV44Q9Z1MIPQ03 | Long             | EC               | CORP              | CA        |     93364 | NS      | $2851336.56   | 0.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Cullinan Therapeutics, Inc.                            | Cullinan Therapeutics, Inc.                            | CUSIP: 230031106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    483951 | NS      | $3760299.27   | 0.52%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC Therapeutics, Inc.                                 | PTC Therapeutics, Inc.                                 | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |    376675 | NS      | $19628534.25  | 2.70%             |  |  |  | No            |                  1 | On Loan: No      |
| Ultragenyx Pharmaceutical, Inc.                        | Ultragenyx Pharmaceutical, Inc.                        | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |    172545 | NS      | $4713929.40   | 0.65%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvalent, Inc.                                         | Nuvalent, Inc., Class A                                | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     56254 | NS      | $4407500.90   | 0.61%             |  |  |  | No            |                  1 | On Loan: No      |
| ArriVent Biopharma, Inc.                               | ArriVent Biopharma, Inc.                               | CUSIP: 04272N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     89500 | NS      | $1746145.00   | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Mirum Pharmaceuticals, Inc.                            | Mirum Pharmaceuticals, Inc.                            | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |    215190 | NS      | $11121019.20  | 1.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Kyverna Therapeutics, Inc.                             | Kyverna Therapeutics, Inc.                             | CUSIP: 501976104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    244900 | NS      | $874293.00    | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| AstraZeneca plc                                        | AstraZeneca plc                                        | CUSIP: 046353108<br>LEI: PY6ZZQWO2IZFZC3IOL08 | Long             | EC               | CORP              | GB        |    205062 | NS      | $14987981.58  | 2.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcutis Biotherapeutics, Inc.                          | Arcutis Biotherapeutics, Inc.                          | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    904886 | NS      | $13193237.88  | 1.81%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvation Bio, Inc.                                     | Nuvation Bio, Inc.                                     | CUSIP: 67080N119<br>LEI: N/A                  | Long             |  | CORP              | US        |    115266 | NS      | $24205.86     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Abivax SA                                              | Abivax SA                                              | CUSIP: 00370M103<br>LEI: 969500D8TMNB184OJU95 | Long             | EC               | CORP              | FR        |    225965 | NS      | $16217508.05  | 2.23%             |  |  |  | No            |                  1 | On Loan: No      |
| CG oncology, Inc.                                      | CG oncology, Inc.                                      | CUSIP: 156944100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    261164 | NS      | $6970467.16   | 0.96%             |  |  |  | No            |                  1 | On Loan: No      |
| MBX Biosciences, Inc.                                  | MBX Biosciences, Inc.                                  | CUSIP: 55287L101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    175851 | NS      | $2330025.75   | 0.32%             |  |  |  | No            |                  1 | On Loan: —       |
| Syndax Pharmaceuticals, Inc.                           | Syndax Pharmaceuticals, Inc.                           | CUSIP: 87164F105<br>LEI: 529900OF94TRHKZVBS87 | Long             | EC               | CORP              | US        |    551449 | NS      | $5470374.08   | 0.75%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals, Inc.                          | Alnylam Pharmaceuticals, Inc.                          | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |     68504 | NS      | $26870008.96  | 3.70%             |  |  |  | No            |                  1 | On Loan: No      |
| Context Therapeutics, Inc.                             | Context Therapeutics, Inc.                             | CUSIP: 21077P108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1479200 | NS      | $1079816.00   | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Ascendis Pharma A/S                                    | Ascendis Pharma A/S                                    | CUSIP: 04351P101<br>LEI: 549300B66JN3W3J8GH73 | Long             | EC               | CORP              | DK        |    161395 | NS      | $28002032.50  | 3.85%             |  |  |  | No            |                  1 | On Loan: No      |
| Oruka Therapeutics, Inc.                               | Oruka Therapeutics, Inc.                               | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |    105128 | NS      | $1428689.52   | 0.20%             |  |  |  | No            |                  1 | On Loan: —       |
| Oruka Therapeutics, Inc.                               | Oruka Therapeutics, Inc.                               | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |    249964 | NS      | $3397010.76   | 0.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Newamsterdam Pharma Co. NV                             | Newamsterdam Pharma Co. NV                             | CUSIP: N/A<br>LEI: 984500B6549TF6E14D36       | Long             | EC               | CORP              | NL        |    117500 | NS      | $2562675.00   | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Crinetics Pharmaceuticals, Inc.                        | Crinetics Pharmaceuticals, Inc.                        | CUSIP: 22663K107<br>LEI: 549300Q1CNFXK5P31D28 | Long             | EC               | CORP              | US        |    228926 | NS      | $6544994.34   | 0.90%             |  |  |  | No            |                  1 | On Loan: No      |
| Olema Pharmaceuticals, Inc.                            | Olema Pharmaceuticals, Inc.                            | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |    677200 | NS      | $3480808.00   | 0.48%             |  |  |  | No            |                  1 | On Loan: No      |
| AnaptysBio, Inc.                                       | AnaptysBio, Inc.                                       | CUSIP: 032724106<br>LEI: 529900HH4WQT03IG1A12 | Long             | EC               | CORP              | US        |    128979 | NS      | $3166434.45   | 0.44%             |  |  |  | No            |                  1 | On Loan: No      |
| Alto Neuroscience, Inc.                                | Alto Neuroscience, Inc.                                | CUSIP: 02157Q109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    263900 | NS      | $810173.00    | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| Structure Therapeutics, Inc.                           | Structure Therapeutics, Inc.                           | CUSIP: 86366E106<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |     34633 | NS      | $616467.40    | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Applied Therapeutics, Inc.                             | Applied Therapeutics, Inc.                             | CUSIP: 03828A101<br>LEI: 549300KL3IJPHZM2GR04 | Long             | EC               | CORP              | US        |    740200 | NS      | $333090.00    | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Vertex Pharmaceuticals, Inc.                           | Vertex Pharmaceuticals, Inc.                           | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |    104652 | NS      | $47812359.24  | 6.58%             |  |  |  | No            |                  1 | On Loan: No      |
| ARS Pharmaceuticals, Inc.                              | ARS Pharmaceuticals, Inc.                              | CUSIP: 82835W108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    561560 | NS      | $9928380.80   | 1.37%             |  |  |  | No            |                  1 | On Loan: —       |
| Artiva Biotherapeutics, Inc.                           | Artiva Biotherapeutics, Inc.                           | CUSIP: 04317A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    192871 | NS      | $578613.00    | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Carmot Therapeutics, Inc.                              | Carmot Therapeutics, Inc.                              | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |     83100 | NS      | $418315.18    | 0.06%             |  |  |  | No            |                  3 | On Loan: No      |
| Acumen Pharmaceuticals, Inc.                           | Acumen Pharmaceuticals, Inc.                           | CUSIP: 00509G209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    826400 | NS      | $1156960.00   | 0.16%             |  |  |  | No            |                  1 | On Loan: —       |
| Institutional Fiduciary Trust Money Market Portfolio   | Institutional Fiduciary Trust Money Market Portfolio   | CUSIP: 8611239C3<br>LEI: N/A                  | Long             | STIV             | RF                | US        |  22093870 | NS      | $22093870.00  | 3.04%             |  |  |  | No            |                  1 | On Loan: No      |
| HilleVax, Inc.                                         | HilleVax, Inc.                                         | CUSIP: 43157M102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    691356 | NS      | $1458761.16   | 0.20%             |  |  |  | No            |                  1 | On Loan: —       |
| EyePoint Pharmaceuticals, Inc.                         | EyePoint Pharmaceuticals, Inc.                         | CUSIP: 30233G209<br>LEI: 549300QE1RU34T50MR69 | Long             | EC               | CORP              | US        |   1038429 | NS      | $10197372.78  | 1.40%             |  |  |  | No            |                  1 | On Loan: No      |
| Bridgebio Pharma, Inc.                                 | Bridgebio Pharma, Inc.                                 | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |    192887 | NS      | $9117768.49   | 1.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Spyre Therapeutics, Inc.                               | Spyre Therapeutics, Inc.                               | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |    220000 | NS      | $3733400.00   | 0.51%             |  |  |  | No            |                  1 | On Loan: No      |
| Achieve Life Sciences, Inc.                            | Achieve Life Sciences, Inc.                            | CUSIP: 004468500<br>LEI: 549300V82ZKZDTAU0A46 | Long             | EC               | CORP              | US        |   1596173 | NS      | $4166011.53   | 0.57%             |  |  |  | No            |                  1 | On Loan: —       |
| BeOne Medicines Ltd.                                   | BeOne Medicines Ltd.                                   | CUSIP: 07725L102<br>LEI: 549300JFUK6FRD5MH739 | Long             | EC               | CORP              | CH        |     14276 | NS      | $4298931.88   | 0.59%             |  |  |  | No            |                  1 | On Loan: No      |
| Centessa Pharmaceuticals plc                           | Centessa Pharmaceuticals plc                           | CUSIP: 152309100<br>LEI: 213800GIDAARDSKOI827 | Long             | EC               | CORP              | GB        |    189736 | NS      | $3257767.12   | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Amgen, Inc.                                            | Amgen, Inc.                                            | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |    143458 | NS      | $42334455.80  | 5.82%             |  |  |  | No            |                  1 | On Loan: No      |
| Avantor, Inc.                                          | Avantor, Inc.                                          | CUSIP: 05352A100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    383929 | NS      | $5160005.76   | 0.71%             |  |  |  | No            |                  1 | On Loan: No      |
| IN8bio, Inc.                                           | IN8bio, Inc.                                           | CUSIP: 45674E208<br>LEI: 549300H68IVCRKSGSL94 | Long             | EC               | CORP              | US        |     69673 | NS      | $148403.49    | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Spyre Therapeutics, Inc.                               | Spyre Therapeutics, Inc.                               | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |     58244 | NS      | $988400.68    | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| Achieve Life Sciences, Inc.                            | Achieve Life Sciences, Inc.                            | CUSIP: N/A<br>LEI: 549300V82ZKZDTAU0A46       | Long             |  | CORP              | US        |   2181025 | NS      | $313526.71    | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| IN8bio, Inc.                                           | IN8bio, Inc., Series C                                 | CUSIP: N/A<br>LEI: 549300H68IVCRKSGSL94       | Long             |  | CORP              | US        |   2090200 | NS      | $7029.34      | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Regeneron Pharmaceuticals, Inc.                        | Regeneron Pharmaceuticals, Inc.                        | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |     59922 | NS      | $32685054.12  | 4.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Gilead Sciences, Inc.                                  | Gilead Sciences, Inc.                                  | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |    481882 | NS      | $54110529.78  | 7.44%             |  |  |  | No            |                  1 | On Loan: No      |
| Thermo Fisher Scientific, Inc.                         | Thermo Fisher Scientific, Inc.                         | CUSIP: 883556102<br>LEI: HCHV7422L5HDJZCRFL38 | Long             | EC               | CORP              | US        |      8579 | NS      | $4012226.72   | 0.55%             |  |  |  | No            |                  1 | On Loan: No      |
| Guardant Health, Inc.                                  | Guardant Health, Inc.                                  | CUSIP: 40131M109<br>LEI: 254900M8C3E5VC8BR186 | Long             | EC               | CORP              | US        |    323366 | NS      | $13251538.68  | 1.82%             |  |  |  | No            |                  1 | On Loan: No      |
| CytomX Therapeutics, Inc.                              | CytomX Therapeutics, Inc.                              | CUSIP: 23284F105<br>LEI: 5493004VW2FW0QLL3345 | Long             | EC               | CORP              | US        |   1573842 | NS      | $3446713.98   | 0.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Structure Therapeutics, Inc.                           | Structure Therapeutics, Inc.                           | CUSIP: 86366E106<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |    159221 | NS      | $2834133.80   | 0.39%             |  |  |  | No            |                  1 | On Loan: —       |
| Institutional Fiduciary Trust - Money Market Portfolio | Institutional Fiduciary Trust - Money Market Portfolio | CUSIP: 457756500<br>LEI: 549300M4TP89K77LG374 | Long             | STIV             | RF                | US        |  17800765 | NS      | $17800764.74  | 2.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Sanofi SA                                              | Sanofi SA, Escrow Account                              | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | CO        |   2333755 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Contineum Therapeutics, Inc.                           | Contineum Therapeutics, Inc., Class A                  | CUSIP: 21217B100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    295058 | NS      | $1740842.20   | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Sionna Therapeutics, Inc.                              | Sionna Therapeutics, Inc.                              | CUSIP: 829401108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    179150 | NS      | $3002554.00   | 0.41%             |  |  |  | No            |                  1 | On Loan: —       |
| Benitec Biopharma, Inc.                                | Benitec Biopharma, Inc.                                | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |    310881 | NS      | $3397898.24   | 0.47%             |  |  |  | No            |                  2 | On Loan: No      |
| Alto Neuroscience, Inc.                                | Alto Neuroscience, Inc.                                | CUSIP: 02157Q109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    165070 | NS      | $506764.90    | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Engene Holdings, Inc.                                  | Engene Holdings, Inc.                                  | CUSIP: 29286M105<br>LEI: N/A                  | Long             | EC               | CORP              | CA        |     87100 | NS      | $330109.00    | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Akebia Therapeutics, Inc.                              | Akebia Therapeutics, Inc.                              | CUSIP: 00972D105<br>LEI: 549300CBQEHMKEEGNX42 | Long             | EC               | CORP              | US        |    895000 | NS      | $3298075.00   | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Terns Pharmaceuticals, Inc.                            | Terns Pharmaceuticals, Inc.                            | CUSIP: 880881107<br>LEI: 254900S1ZDQMF4MYP709 | Long             | EC               | CORP              | US        |    449500 | NS      | $2620585.00   | 0.36%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2025-09-02

**Name of Applicant:** Franklin Strategic Series

**Signature:** Monica Krogh

**Name of Signer:** Monica Krogh

**Title:** Assistant Treasurer