# EDGAR Filing Document

**Accession Number:** 0001157601
**File Stem:** 0001104659-25-061176
**Filing Date:** 2025-6
**Character Count:** 187887
**Document Hash:** 1e21606541cf0815096490fda6ad3c85
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-25-061176.hdr.sgml**: 20250620

**ACCESSION NUMBER**: 0001104659-25-061176

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 20

**FILED AS OF DATE**: 20250620

**DATE AS OF CHANGE**: 20250620

**EFFECTIVENESS DATE**: 20250620

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** MADRIGAL PHARMACEUTICALS, INC.
- **CENTRAL INDEX KEY:** 0001157601
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-288200
- **FILM NUMBER:** 251061674

**BUSINESS ADDRESS:**
- **STREET 1:** 200 BARR HARBOR DRIVE, SUITE 400
- **CITY:** WEST CONSHOHOCKEN
- **STATE:** PA
- **ZIP:** 19428
- **BUSINESS PHONE:** 404-380-9263

**MAIL ADDRESS:**
- **STREET 1:** 200 BARR HARBOR DRIVE, SUITE 400
- **CITY:** WEST CONSHOHOCKEN
- **STATE:** PA
- **ZIP:** 19428

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** SYNTA PHARMACEUTICALS CORP
- **DATE OF NAME CHANGE:** 20010815

**As filed with the Securities and Exchange Commission on June 20, 2025**

 **Registration No. 333-**

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**FORM S-8**

**REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933**

------

**MADRIGAL PHARMACEUTICALS, INC.**

**(Exact name of registrant as specified in its charter)**

------

---

| | |
|:---|:---|
| **Delaware** | **04-3508648** |
| **(State or other jurisdiction of**<br> **incorporation or organization)** | **(I.R.S. Employer**<br> **Identification No.)** |

---

**Four Tower Bridge**

**200 Barr Harbor Drive, Suite 200**

**West Conshohocken, Pennsylvania 19428**

(Address of Principal Executive Offices, Zip Code)

**MADRIGAL PHARMACEUTICALS, INC. 2025 INDUCEMENT STOCK PLAN**

(Full title of the plan)

**Mardi Dier**

**Senior Vice President and Chief Financial Officer**

**Madrigal Pharmaceuticals, Inc.**

**Four Tower Bridge**

**200 Barr Harbor Drive, Suite 200**

**West Conshohocken, Pennsylvania 19428**

(Name and address of agent for service)

**(267) 824-2827**

(Telephone number, including area code, of agent for service)

------

***Copies to:***

**Gregg Katz, Esq.**

**Goodwin Procter LLP**

**100 Northern Avenue**

**Boston, MA 02210**

**(617) 570-1000**

------

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | x | Accelerated filer | ¨ |
| Non-accelerated filer | ¨ | Smaller reporting company | ¨ |
|  |  | Emerging growth company | ¨ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ◻

**EXPLANATORY NOTE**

This Registration Statement on Form S-8 (the "Registration Statement") is being filed for the purpose of registering 100,000 shares of common stock, par value $0.0001 per share (the "Common Stock"), reserved and available for issuance under the 2025 Inducement Stock Plan (the "2025 Inducement Plan") of Madrigal Pharmaceuticals, Inc. (the "Company").

On June 16, 2025, the Board of Directors of the Company adopted the 2025 Inducement Plan. The 2025 Inducement Plan was adopted without stockholder approval pursuant to Nasdaq Listing Rule 5635(c)(4) and will be administered by the Compensation Committee of the Board.

The only persons eligible to receive grants of Inducement Awards (as defined below) under the Inducement Plan are individuals who satisfy the standards for inducement grants under Nasdaq Listing Rule 5635(c)(4). An "Inducement Award" means any right to receive the Company's common stock, cash or other property granted under the Inducement Plan (including nonqualified stock options, restricted stock awards, restricted stock unit awards, stock appreciation rights, performance stock awards or other stock-based awards).

**Part I**

**INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS**

**Item 1.** **Plan Information.**

Not required to be filed with this Registration Statement.

**Item 2.** **Registrant Information and Employee Plan Annual Information.**

Not required to be filed with this Registration Statement.

**Part II**

**INFORMATION REQUIRED IN THE REGISTRATION STATEMENT**

**Item 3.** **Incorporation of Documents by Reference.**

The following documents, which have been filed by the Registrant with the SEC, are incorporated by reference in this Registration Statement (excluding any portions of such documents that have been "furnished" but not "filed" for purposes of the Securities Exchange Act of 1934, as amended (the "Exchange Act")):

(a) [Annual Report on Form 10-K for the fiscal year ended December 31, 2024, as filed with the SEC on February 26, 2025](https://www.sec.gov/ix?doc=/Archives/edgar/data/1157601/000162828025007980/mdgl-20241231.htm) , including
 the information specifically incorporated therein by reference from our [Definitive Proxy Statement on Schedule 14A, as filed with the SEC on April 29, 2025](https://www.sec.gov/ix?doc=/Archives/edgar/data/1157601/000110465925041254/tm2512589-3_def14a.htm) ;

(b) [Quarterly Report on Form 10-Q for the fiscal quarter ended March 31, 2025 as filed with the SEC on May 1, 2025](https://www.sec.gov/ix?doc=/Archives/edgar/data/1157601/000162828025021356/mdgl-20250331.htm) ;

(c) Current
 Reports on Form 8-K, as filed with the SEC on [March 11, 2025 (Item 5.02)](https://www.sec.gov/ix?doc=/Archives/edgar/data/1157601/000119312525051461/d916063d8k.htm) , [April 17, 2025](https://www.sec.gov/ix?doc=/Archives/edgar/data/1157601/000162828025018242/mdgl-20250416.htm) and [June 20, 2025](https://www.sec.gov/ix?doc=/Archives/edgar/data/1157601/000162828025032358/mdgl-20250620.htm) ; and

(d) The description
 of the Registrant's common stock contained in its [Registration Statement on Form 8-A filed with the SEC on January 26, 2007](https://www.sec.gov/Archives/edgar/data/1157601/000110465907004817/a07-2607_18a12b.htm) , including any amendment thereto or report filed for the purpose of updating such description, including but not limited to
 the description of the Registrant's common stock contained in [Exhibit 4.3](https://www.sec.gov/Archives/edgar/data/1157601/000119312523045575/d437449dex43.htm) to the Registrant's Annual Report on Form 10-K for
 the fiscal year ended December 31, 2022 filed with the SEC on February 23, 2023.

All documents that the Registrant subsequently files under Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective amendment which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference in this Registration Statement and to be a part hereof from the date of filing of such documents (excluding any portions of such documents that have been "furnished" but not "filed" for purposes of the Exchange Act). Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for the purposes of this Registration Statement to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.

Under no circumstances will any information filed under current items 2.02 or 7.01 of Form 8-K be deemed incorporated herein by reference unless such Form 8-K expressly provides to the contrary.

**Item 4.** **Description of Securities.**

Not applicable.

**Item 5.** **Interests of Named Experts and Counsel.**

Not applicable.

**Item 6.** **Indemnification of Directors and Officers.**

Our restated certificate of incorporation, as amended, and restated bylaws provide that each person who was or is made a party or is threatened to be made a party to or is otherwise involved (including, without limitation, as a witness) in any action, suit or proceeding, whether civil, criminal, administrative or investigative, by reason of the fact that he or she is or was a director or an officer of our company or is or was serving at our request as a director, officer, or trustee of another corporation, or of a partnership, joint venture, trust or other enterprise, including service with respect to an employee benefit plan, whether the basis of such proceeding is alleged action in an official capacity as a director, officer or trustee or in any other capacity while serving as a director, officer or trustee, shall be indemnified and held harmless by us to the fullest extent permitted by the Delaware General Corporation Law against all expense, liability and loss (including attorneys' fees, judgments, fines, ERISA excise taxes or penalties and amounts paid in settlement) reasonably incurred or suffered by such person in connection therewith.

Section 145 of the Delaware General Corporation Law permits a corporation to indemnify any director or officer of the corporation against expenses (including attorneys' fees), judgments, fines and amounts paid in settlement actually and reasonably incurred in connection with any action, suit or proceeding brought by reason of the fact that such person is or was a director or officer of the corporation, if such person acted in good faith and in a manner that he or she reasonably believed to be in, or not opposed to, the best interests of the corporation, and, with respect to any criminal action or proceeding, if he or she had no reason to believe his or her conduct was unlawful. In a derivative action, (*i.e*., one brought by or on behalf of the corporation), indemnification may be provided only for expenses actually and reasonably incurred by any director or officer in connection with the defense or settlement of such an action or suit if such person acted in good faith and in a manner that he or she reasonably believed to be in, or not opposed to, the best interests of the corporation, except that no indemnification shall be provided if such person shall have been adjudged to be liable to the corporation, unless and only to the extent that the court in which the action or suit was brought shall determine that the defendant is fairly and reasonably entitled to indemnity for such expenses despite such adjudication of liability.

Pursuant to Section 102(b)(7) of the Delaware General Corporation Law, Articles Ninth and Twelfth of our restated certificate of incorporation, as amended, eliminate the liability of directors and certain senior officers to us or our stockholders for monetary damages for such a breach of fiduciary duty as a director or senior officer, except for liability:

· of any director or officer for any breach of the director's or officer's duty of loyalty to us or our stockholders;

· of any director or officer for acts or omissions not in good faith or which involve intentional misconduct or a knowing violation of law;

· of any director under Section 174 of the Delaware General Corporation Law;

· of any director or officer for any transaction from which the director or officer derived an improper personal benefit; and

· of any officer in any action by or in the right of the corporation.

We carry insurance policies insuring our directors and officers against certain liabilities that they may incur in their capacity as directors and officers. In addition, we have entered into indemnification agreements with our directors and officers.

**Item 7.** **Exemption from Registration Claimed.**

Not applicable.

**Item 8.** **Exhibits.**

The exhibits listed on the Exhibit Index immediately preceding such exhibits are filed as part of this Registration Statement, and the contents of the Exhibit Index are incorporated herein by reference.

**EXHIBIT INDEX**

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| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| | | | **Incorporated by Reference** | **Incorporated by Reference** | **Incorporated by Reference** | **Incorporated by Reference** |
| <br>**Exhibit<br> Number** | <br>**Exhibit Description** | <br>**Filed<br> Herewith** | **Form** | **SEC File /<br> Registration<br> Number** | **Exhibit** | **Filing<br> Date** |
| [4.1](https://www.sec.gov/Archives/edgar/data/1157601/000104746917002260/a2231593zex-3_1.htm) | [Restated Certificate of Incorporation of the Registrant](https://www.sec.gov/Archives/edgar/data/1157601/000104746917002260/a2231593zex-3_1.htm) |  | [10-K](https://www.sec.gov/Archives/edgar/data/1157601/000104746917002260/a2231593zex-3_1.htm) | [001-33277](https://www.sec.gov/Archives/edgar/data/1157601/000104746917002260/a2231593zex-3_1.htm) | [3.1](https://www.sec.gov/Archives/edgar/data/1157601/000104746917002260/a2231593zex-3_1.htm) | [03/31/17](https://www.sec.gov/Archives/edgar/data/1157601/000104746917002260/a2231593zex-3_1.htm) |
| [4.2](https://www.sec.gov/Archives/edgar/data/1157601/000119312523169187/d521638dex31.htm) | [Certificate of Amendment to Restated Certificate of Incorporation of the Registrant](https://www.sec.gov/Archives/edgar/data/1157601/000119312523169187/d521638dex31.htm) |  | [8-K](https://www.sec.gov/Archives/edgar/data/1157601/000119312523169187/d521638dex31.htm) | [001-33277](https://www.sec.gov/Archives/edgar/data/1157601/000119312523169187/d521638dex31.htm) | [3.1](https://www.sec.gov/Archives/edgar/data/1157601/000119312523169187/d521638dex31.htm) | [06/20/23](https://www.sec.gov/Archives/edgar/data/1157601/000119312523169187/d521638dex31.htm) |
| [4.3](https://www.sec.gov/Archives/edgar/data/1157601/000110465916111348/a16-8380_1ex3d1.htm) | [Restated Bylaws of the Registrant](https://www.sec.gov/Archives/edgar/data/1157601/000110465916111348/a16-8380_1ex3d1.htm) |  | [8-K](https://www.sec.gov/Archives/edgar/data/1157601/000110465916111348/a16-8380_1ex3d1.htm) | [001-33277](https://www.sec.gov/Archives/edgar/data/1157601/000110465916111348/a16-8380_1ex3d1.htm) | [3.1](https://www.sec.gov/Archives/edgar/data/1157601/000110465916111348/a16-8380_1ex3d1.htm) | [04/14/16](https://www.sec.gov/Archives/edgar/data/1157601/000110465916111348/a16-8380_1ex3d1.htm) |
| [5.1](tm2518336d1_ex5-1.htm) | [Opinion of Goodwin Procter LLP](tm2518336d1_ex5-1.htm) | [X](tm2518336d1_ex5-1.htm) |  |  |  |  |
| [23.1](tm2518336d1_ex5-1.htm) | [Consent of Goodwin Procter LLP (included in opinion of counsel filed as Exhibit 5.1)](tm2518336d1_ex5-1.htm) | [X](tm2518336d1_ex5-1.htm) |  |  |  |  |
| [23.2](tm2518336d1_ex23-2.htm) | [Consent of PricewaterhouseCoopers LLP](tm2518336d1_ex23-2.htm) | [X](tm2518336d1_ex23-2.htm) |  |  |  |  |
| [24](#v1) | [Power of Attorney to file future amendments (set forth on the signature page of this Registration Statement)](#v1) | [X](#v1) |  |  |  |  |
| [99.1](tm2518336d1_ex99-1.htm) | [2025 Inducement Plan](tm2518336d1_ex99-1.htm) | [X](tm2518336d1_ex99-1.htm) |  |  |  |  |
| [99.2](tm2518336d1_ex99-2.htm) | [Form of Non-Qualified Stock Option Agreement](tm2518336d1_ex99-2.htm) | [X](tm2518336d1_ex99-2.htm) |  |  |  |  |
| [99.3](tm2518336d1_ex99-3.htm) | [Form of Restricted Stock Unit Award Agreement (Non-Section 16 Officers)](tm2518336d1_ex99-3.htm) | [X](tm2518336d1_ex99-3.htm) |  |  |  |  |
| [99.4](tm2518336d1_ex99-4.htm) | [Form of Restricted Stock Unit Award Agreement (Section 16 Officers)](tm2518336d1_ex99-4.htm) | [X](tm2518336d1_ex99-4.htm) |  |  |  |  |
| [99.5](tm2518336d1_ex99-5.htm) | [Form of Performance-Based Restricted Stock Unit Award Agreement](tm2518336d1_ex99-5.htm) | [X](tm2518336d1_ex99-5.htm) |  |  |  |  |
| [107](tm2518336d1_ex-filingfees.htm) | [Filing Fee table](tm2518336d1_ex-filingfees.htm) | [X](tm2518336d1_ex-filingfees.htm) |  |  |  |  |

---

**Item 9.** **Undertakings.**

(a) The undersigned Registrant hereby undertakes:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) To include any prospectus required by Section 10(a)(3) of the Securities Act of 1933;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20% change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective registration statement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement;

*Provided, however*, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in this registration statement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

(b) The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act of 1933, each filing of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in this registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

(c) Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Act and will be governed by the final adjudication of such issue.

**SIGNATURES**

Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in West Conshohocken, Pennsylvania, on June 20, 2025.

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| | |
|:---|:---|
| **MADRIGAL PHARMACEUTICALS, INC.** | **MADRIGAL PHARMACEUTICALS, INC.** |
| By: | /s/ William J. Sibold  |
|  | William J. Sibold |
|  | President and Chief Executive Officer |

---

**POWER OF ATTORNEY**

Each person whose signature appears below constitutes and appoints William J. Sibold and Mardi Dier, and each of them singly, his or her true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution in each of them singly, for him or her and in his or her name, place and stead, and in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement of Madrigal Pharmaceuticals, Inc. and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting to the attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite or necessary to be done in or about the premises, as full to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that the attorneys-in-fact and agents or any of each of them or their substitute may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

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| | | |
|:---|:---|:---|
| **Name** | **Title** | **Date** |
| /s/ William J. Sibold<br> William J. Sibold | President and Chief Executive Officer and Director<br> (Principal Executive Officer) | June 20, 2025 |
| /s/ Mardi C. Dier<br> Mardi C. Dier | Chief Financial Officer<br> (Principal Financial and Accounting Officer) | June 20, 2025 |
| /s/ Julian C. Baker<br> Julian C. Baker | Chairman of the Board | June 20, 2025 |
| /s/ Kenneth M. Bate<br> Kenneth M. Bate | Director | June 20, 2025 |
| /s/ Raymond Cheong, M.D., Ph.D.<br> Raymond Cheong, M.D., Ph.D. | Director | June 20, 2025 |
| /s/ Fred B. Craves, Ph.D.<br> Fred B. Craves, Ph.D. | Director | June 20, 2025 |
| /s/ James M. Daly<br> James M. Daly | Director | June 20, 2025 |
| /s/ Paul A. Friedman, M.D.<br> Paul A. Friedman, M.D. | Director | June 20, 2025 |
| /s/ Jacqualyn A. Fouse, Ph.D.<br> Jacqualyn A. Fouse, Ph.D. | Director | June 20, 2025 |
| /s/ Richard S. Levy, M.D.<br> Richard S. Levy, M.D. | Director | June 20, 2025 |
| /s/ Rebecca Taub, M.D.<br> Rebecca Taub, M.D. | Senior Scientific and Medical Advisor and Director | June 20, 2025 |

---

## Exhibit 5.1

**Exhibit 5.1**

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| | |
|:---|:---|
| ![](tm2518336d1_ex5-1img001.jpg) | Goodwin Procter llp<br>100 Northern Avenue<br> Boston, MA 02210<br>goodwinlaw.com<br>+1 415 733 6000 |

---

June 20, 2025

Madrigal Pharmaceuticals, Inc.

Four Tower Bridge

200 Barr Harbor Drive, Suite 200

West Conshohocken, PA 19428

Re: <u>Securities Being Registered under Registration Statement on Form S-8</u>

We have acted as your counsel in connection with your filing of a Registration Statement on Form S-8 (the "<u>Registration Statement</u>") pursuant to the Securities Act of 1933, as amended (the "<u>Securities Act</u>"), on or about the date hereof relating to an aggregate of 100,000 shares (the "<u>Shares</u>") of Common Stock, par value $0.0001 per share ("<u>Common Stock</u>"), of Madrigal Pharmaceuticals, Inc., a Delaware corporation (the "<u>Company</u>"), that may be issued pursuant to the Madrigal Pharmaceuticals, Inc. 2025 Inducement Stock Plan (the "<u>Plan</u>").

We have reviewed such documents and made such examination of law as we have deemed appropriate to give the opinion set forth below. We have relied, without independent verification, on certificates of public officials and, as to matters of fact material to the opinion set forth below, on certificates of officers of the Company.

For purposes of the opinion set forth below, we have assumed that, at the time Shares are issued, the total number of then unissued Shares, when added to the number of shares of Common Stock issued, subscribed for, or otherwise committed to be issued, does not exceed the number of shares of Common Stock authorized by the Company's certificate of incorporation.

The opinion set forth below is limited to the Delaware General Corporation Law.

Based on the foregoing, we are of the opinion that the Shares have been duly authorized and, when delivered against payment therefor in accordance with the terms of the Plan, will be validly issued, fully paid and nonassessable.

This opinion letter and the opinion it contains shall be interpreted in accordance with the Core Opinion Principles as published in 74 *Business Lawyer* 815 (Summer 2019).

Madrigal Pharmaceuticals, Inc.

June 20, 2025

We hereby consent to the inclusion of this opinion as Exhibit 5.1 to the Registration Statement. In giving our consent, we do not admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations thereunder.

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| |
|:---|
| Very truly yours, |
| /s/ Goodwin Procter LLP |
| GOODWIN PROCTER LLP |

---

## Exhibit 23.2

**Exhibit 23.2**

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in this Registration Statement on Form S-8 of Madrigal Pharmaceuticals, Inc. of our report dated February 26, 2025 relating to the financial statements and the effectiveness of internal control over financial reporting, which appears in Madrigal Pharmaceuticals, Inc.'s Annual Report on Form 10-K for the year ended December 31, 2024.

---

| |
|:---|
| /s/ PricewaterhouseCoopers LLP |
| Philadelphia, Pennsylvania |
| June 20, 2025 |

---

## Exhibit 99.1

**Exhibit 99.1**

**MADRIGAL PHARMACEUTICALS, INC.**

**2025 INDUCEMENT STOCK PLAN**

1. DEFINITIONS.

Unless otherwise specified or unless the context otherwise requires, the following terms, as used in this Madrigal Pharmaceuticals, Inc. 2025 Inducement Stock Plan, have the following meanings:

"***Administrator***" means the Board of Directors, unless it has delegated power to act on its behalf to the Committee, in which case the Administrator means the Committee.

"***Affiliate***" means a corporation which, for purposes of Section 424 of the Code, is a parent or subsidiary of the Company, direct or indirect.

"***Agreement***" means an agreement between the Company and a Participant pertaining to a Stock Right granted pursuant to the Plan, in such form as the Administrator shall approve.

"***Board of Directors***" means the Board of Directors of the Company.

"***Cause***" means, with respect to a Participant, (a) dishonesty with respect to the Company or any Affiliate, (b) insubordination, substantial malfeasance or non-feasance of duty, (c) unauthorized disclosure of confidential information, (d) breach by a Participant of any provision of any employment, consulting, advisory, nondisclosure, non-competition or similar agreement between the Participant and the Company or any Affiliate, or (e) conduct substantially prejudicial to the business of the Company or any Affiliate; provided, however, that any provision in an agreement between a Participant and the Company or an Affiliate, which contains a conflicting definition of Cause for termination and which is in effect at the time of such termination, shall supersede this definition with respect to that Participant. The determination of the Administrator as to the existence of Cause will be conclusive on the Participant and the Company.

"***Change of Control***" means the occurrence of any of the following events:

(a) Ownership. Any "Person" (as such term is used in Sections 13(d) and 14(d) of the Exchange Act) becomes the "Beneficial Owner" (as defined in Rule 13d-3 under the Exchange Act), directly or indirectly, of securities of the Company representing 50% or more of the total voting power represented by the Company's then outstanding voting securities (excluding for this purpose any such voting securities held by the Company or its Affiliates or by any employee benefit plan of the Company) pursuant to a transaction or a series of related transactions which the Board of Directors does not approve; or

(b) Merger/Sale of Assets. (i) A merger or consolidation of the Company, whether or not approved by the Board of Directors, other than a merger or consolidation which would result in the voting securities of the Company outstanding immediately prior thereto continuing to represent (either by remaining outstanding or by being converted into voting securities of the surviving entity or the parent of such corporation) more than 50% of the total voting power represented by the voting securities of the Company or such surviving entity or parent of such corporation, as the case may be, outstanding immediately after such merger or consolidation; or (ii) the sale or disposition by the Company of all or substantially all of the Company's assets in a transaction requiring shareholder approval; or

(c) Change in Board Composition. A change in the composition of the Board of Directors, as a result of which fewer than a majority of the directors are Incumbent Directors. "***Incumbent Directors***" means directors who either (i) are directors of the Company as of the date of adoption of the Plan, or (ii) are elected, or nominated for election, to the Board of Directors with the affirmative votes of at least a majority of the Incumbent Directors at the time of such election or nomination (but shall not include an individual whose election or nomination is in connection with an actual or threatened proxy contest relating to the election of directors to the Company);

provided, however, that if any payment or benefit payable hereunder upon or following a Change of Control would be required to comply with the limitations of Section 409A(a)(2)(A)(v) of the Code in order to avoid an additional tax under Section 409A of the Code, such payment or benefit shall be made only if such Change of Control constitutes a change in ownership or control of the Company, or a change in ownership of the Company's assets in accordance with Section 409A of the Code.

"***Code***" means the United States Internal Revenue Code of 1986, as amended, including any successor statute, regulation and guidance thereto.

"***Committee***" means either the independent members of the Board or the compensation committee of the Board of Directors to which the Board of Directors has delegated power to act under or pursuant to the provisions of the Plan.

"***Common Stock***" means shares of the Company's common stock, $.0001 par value per share.

"***Company***" means Madrigal Pharmaceuticals, Inc., a Delaware corporation, and its successors.

"***Disability***" or "***Disabled***" means permanent and total disability as defined in Section 22(e)(3) of the Code.

"***Exchange Act***" means the Securities Exchange Act of 1934, as amended.

"***Fair Market Value***" of a Share means:

(a) If the Shares are listed on a national securities exchange or traded in the over-the-counter market and sales prices are regularly reported for the Shares, the closing or, if not applicable, the last price of the Shares on the composite tape or other comparable reporting system for the trading day on the applicable date and if such applicable date is not a trading day, the last market trading day prior to such date;

(b) If the Shares are not traded on a national securities exchange but are traded on the over-the-counter market, if sales prices are not regularly reported for the Shares for the trading day referred to in clause (a), and if bid and asked prices for the Shares are regularly reported, the mean between the bid and the asked price for the Shares at the close of trading in the over-the-counter market for the trading day on which the Shares were traded on the applicable date and if such applicable date is not a trading day, the last market trading day prior to such date; and

(c) If the Shares are neither listed on a national securities exchange nor traded in the over-the-counter market, such value as the Administrator, in good faith, determines in compliance with applicable laws.

"***ISO***" means an Option intended to qualify as an incentive stock option under Section 422 of the Code.

"***Non***-***Qualified Option***" means an Option which is not intended to qualify as an ISO.

"***Option***" means an option to purchase Shares at a specified price pursuant to the Plan.

"***Option Agreement***" means an Agreement pertaining to an Option granted pursuant to the Plan.

"***Participant***" means a prospective officers or employee who is not currently employed by the Company or its Affiliates to whom the Company may issue securities without stockholder approval as an inducement pursuant to Rule 5635(c)(4) of the Marketplace Rules of the Nasdaq Stock Market, Inc. As used herein, "Participant" shall include such Participant's "Survivors" where the context requires.

"***Plan***" means this Madrigal Pharmaceuticals, Inc. 2025 Inducement Stock Plan, as it may be amended and/or restated from time to time.

"***Securities Act***" means the Securities Act of 1933, as amended.

"***Shares***" means shares of the Common Stock as to which Stock Rights have been or may be granted under the Plan or any shares of capital stock into which the Shares are changed or for which they are exchanged within the provisions of Paragraph 3 of the Plan. The Shares issued under the Plan may be authorized and unissued shares or shares held by the Company in its treasury, or both.

"***Stock***-***Based Award***" means a grant by the Company under the Plan of an equity award or an equity based award which is not an Option or a Stock Grant.

"***Stock Grant***" means a grant by the Company of Shares under the Plan.

"***Stock Right***" means a right to Shares or the value of Shares of the Company granted pursuant to the Plan—a Non-Qualified Option, a Stock Grant or a Stock-Based Award.

"***Survivor***" means a deceased Participant's legal representatives and/or any person or persons who acquired the Participant's rights to a Stock Right by will or by the laws of descent and distribution.

2. PURPOSE OF THE PLAN.

The purpose of the Plan is to encourage and enable the Company to grant equity awards to induce highly-qualified prospective officers and employees who are not currently employed by the Company and its Affiliates to accept employment and provide them with a proprietary interest in the Company. The Plan is intended to encourage ownership of Shares by such Participants in order to attract such Participants, to induce them to work for the benefit of the Company or an Affiliate and to provide additional incentive for them to promote the success of the Company or of an Affiliate. The Company intends that this Plan be reserved for persons to whom the Company may issue securities without stockholder approval as an inducement pursuant to Rule 5635(c)(4) of the Marketplace Rules of the Nasdaq Stock Market, Inc. The Plan provides for the granting of Non-Qualified Options, Stock Grants and Stock-Based Awards.

3. SHARES SUBJECT TO THE PLAN.

(a) The number of Shares which may be issued from time to time pursuant to this Plan shall be 100,000 shares of Common Stock or the equivalent of such number of Shares after the Administrator, in its sole discretion, has interpreted the effect of any stock split, stock dividend, combination, recapitalization or similar transaction in accordance with Paragraph 23 of this Plan. Any of the Shares reserved and available for issuance under the Plan may be used for any type of Stock Right under the Plan.

(b) If an Option ceases to be outstanding, in whole or in part (other than by exercise), or if any Stock Right expires or is forfeited, cancelled, or otherwise terminated or results in any Shares not being issued, the unissued or reacquired Shares which were subject to such Stock Right shall again be available for issuance from time to time pursuant to this Plan. In addition, if a Stock Right is exercised, in whole or in part, by tender of Shares or if the Company or an Affiliate's tax withholding obligation is satisfied by withholding Shares, the number of Shares deemed to have been issued under the Plan for purposes of the limitation set forth in Paragraph 3(a) above shall be the net number of Shares actually issued.

4. ADMINISTRATION OF THE PLAN.

The Administrator of the Plan will be the Board of Directors, except to the extent the Board of Directors delegates its authority to the Committee, in which case the Committee shall be the Administrator.

Subject to the provisions of the Plan, the Administrator is authorized to:

(a) Interpret the provisions of the Plan and all Stock Rights and to make all rules and determinations which it deems necessary or advisable for the administration of the Plan;

(b) Determine which Participants shall be granted Stock Rights;

(c) Determine the number of Shares for which a Stock Right or Stock Rights shall be granted;

(d) Specify the terms and conditions upon which a Stock Right or Stock Rights may be granted;

(e) Accelerate the exercisability, vesting or lapse of forfeiture restrictions of a Stock Right;

(f) Amend any term or condition of any outstanding Stock Right, other than reducing the exercise price or purchase price, provided that (i) such term or condition as amended is not prohibited by the Plan; (ii) any such amendment shall not impair the rights of a Participant under any Stock Right previously granted without such Participant's consent or in the event of death of the Participant the Participant's Survivors; and (iii) any such amendment shall be made only after the Administrator determines whether such amendment would cause any adverse tax consequences to the Participant, including, but not limited to, pursuant to Section 409A of the Code; and

(g) Adopt any sub-plans applicable to residents of any specified jurisdiction as it deems necessary or appropriate in order to comply with or take advantage of any tax or other laws applicable to the Company, any Affiliate or to Participants or to otherwise facilitate the administration of the Plan, which sub-plans may include additional restrictions or conditions applicable to Stock Rights or Shares issuable pursuant to a Stock Right;

provided, however, that all such interpretations, rules, determinations, terms and conditions shall be made and prescribed in the context of not causing any adverse tax consequences under Section 409A of the Code. Subject to the foregoing, the interpretation and construction by the Administrator of any provisions of the Plan or of any Stock Right granted under it shall be final, unless otherwise determined by the Board of Directors, if the Administrator is the Committee. In addition, if the Administrator is the Committee, the Board of Directors may take any action under the Plan that would otherwise be the responsibility of the Committee.

5. ELIGIBILITY FOR PARTICIPATION.

The Administrator will, in its sole discretion, name the Participants in the Plan, provided, however, that each Participant must be an employee of the Company or of an Affiliate at the time a Stock Right is granted. Notwithstanding the foregoing, the Administrator may authorize the grant of a Stock Right to a person not then an employee of the Company or of an Affiliate; provided, however, that the actual grant of such Stock Right shall be conditioned upon such person becoming eligible to become a Participant at or prior to the time of the execution of the Agreement evidencing such Stock Right. The granting of any Stock Right to any individual shall neither entitle that individual to, nor disqualify him or her from, participation in any other grant of Stock Rights or any grant under any other benefit plan established by the Company or any Affiliate.

6. TERMS AND CONDITIONS OF OPTIONS.

Each Option shall be set forth in writing in an Option Agreement, duly executed by the Company and, to the extent required by law or requested by the Company, by the Participant. The Administrator may provide that Options be granted subject to such terms and conditions, consistent with the terms and conditions specifically required under this Plan, as the Administrator may deem appropriate including, without limitation, subsequent approval by the shareholders of the Company of this Plan or any amendments thereto. The Option Agreements shall be subject to at least the following terms and conditions:

(a) Each Non-Qualified Option shall be subject to the terms and conditions which the Administrator determines to be appropriate and in the best interest of the Company, subject to the following minimum standards for any such Non-Qualified Option:

(i) Exercise Price: Each Option Agreement shall state the exercise price (per share) of the Shares covered by each Option, which exercise
price shall be determined by the Administrator and shall be at least equal to the Fair Market Value per Share on the date of the grant
of the Option.

(ii) Number of Shares: Each Option Agreement shall state the number of Shares to which it pertains.

(iii) Vesting: Subject to Paragraph 28, each Option Agreement shall state the date or dates on which it first is exercisable and the date
after which it may no longer be exercised, and may provide that the Option rights accrue or become exercisable in installments over a
period of months or years, or upon the occurrence of certain performance criteria or the attainment of stated goals or events.

(iv) Term of Option: Each Option shall terminate not more than ten years from the date of the grant or at such earlier time as the Option
Agreement may provide.

7. TERMS AND CONDITIONS OF STOCK GRANTS.

Each Stock Grant to a Participant shall state the principal terms in an Agreement, duly executed by the Company and, to the extent required by law or requested by the Company, by the Participant. The Agreement shall be in a form approved by the Administrator and shall contain terms and conditions which the Administrator determines to be appropriate and in the best interest of the Company, subject to the following minimum standards:

(a) Each Agreement shall state the purchase price (per share), if any, of the Shares covered by each Stock Grant, which purchase price shall be determined by the Administrator but shall not be less than the minimum consideration required by the Delaware General Corporation Law, if any, on the date of the grant of the Stock Grant;

(b) Each Agreement shall state the number of Shares to which the Stock Grant pertains;

(c) Each Agreement shall include the terms of any right of the Company to restrict or reacquire the Shares subject to the Stock Grant, including the time period or attainment of performance criteria upon which such rights shall accrue (subject to Paragraph 28) and the purchase price therefor, if any; and

(d) Each Agreement shall provide that cash dividends declared or paid on Stock Grants that remain subject to time-based or performance-based vesting requirements shall not become payable unless and until the Stock Grant (or portion thereof) to which the dividends apply become vested and nonforfeitable.

8. TERMS AND CONDITIONS OF OTHER STOCK-BASED AWARDS.

The Administrator shall have the right to grant other Stock-Based Awards based upon the Shares having such terms and conditions as the Administrator may determine, including, without limitation, the grant of Shares based upon certain conditions, the grant of securities convertible into Shares and the grant of stock appreciation rights, phantom stock awards or stock units. The principal terms of each Stock-Based Award shall be set forth in an Agreement, duly executed by the Company and, to the extent required by law or requested by the Company, by the Participant. The Agreement shall be in a form approved by the Administrator and shall contain terms and conditions which the Administrator determines to be appropriate and in the best interest of the Company. Each Agreement shall include the terms of any right of the Company, including the right to terminate the Stock-Based Award without the issuance of Shares, and the terms of any vesting conditions, performance criteria or events upon which Shares shall be issued (subject to Paragraph 29). Under no circumstances may the Agreement covering stock appreciation rights (a) have an exercise price per Share that is less than the Fair Market Value per Share on the date of grant or (b) expire more than ten years following the date of grant. Each Agreement shall provide that cash dividends declared or paid on Shares subject to Stock-Based Awards that remain subject to time-based or performance-based vesting requirements shall not become payable unless and until the Stock-Based Award (or portion thereof) to which the dividends apply become vested and nonforfeitable.

The Company intends that the Plan and any Stock-Based Awards granted hereunder be exempt from the application of Section 409A of the Code or meet the requirements of paragraphs (2), (3) and (4) of subsection (a) of Section 409A of the Code, to the extent applicable, and be operated in accordance with Section 409A so that any compensation deferred under any Stock-Based Award (and applicable investment earnings) shall not be included in income under Section 409A of the Code. Any ambiguities in the Plan shall be construed to effect the intent as described in this Paragraph 8.

9. EXERCISE OF OPTIONS AND ISSUE OF SHARES.

An Option (or any part or installment thereof) shall be exercised by giving written notice to the Company or its designee (in a form acceptable to the Administrator, which may include electronic notice), together with provision for payment of the aggregate exercise price in accordance with this Paragraph 9 for the Shares as to which the Option is being exercised, and upon compliance with any other condition(s) set forth in the Option Agreement. Such notice shall be signed by the person exercising the Option (which signature may be provided electronically in a form acceptable to the Administrator), shall state the number of Shares with respect to which the Option is being exercised and shall contain any representation required by the Plan or the Option Agreement. Payment of the exercise price for the Shares as to which such Option is being exercised shall be made (a) in United States dollars in cash or by check; or (b) at the discretion of the Administrator, through delivery of Shares (held for such period if and to the extent required to avoid negative accounting treatment) having a Fair Market Value equal as of the date of the exercise to the aggregate cash exercise price for the number of Shares as to which the Option is being exercised; or (c) at the discretion of the Administrator, by having the Company retain from the Shares otherwise issuable upon exercise of the Option, a number of Shares having a Fair Market Value equal as of the date of exercise to the aggregate exercise price for the number of Shares as to which the Option is being exercised; or (d) at the discretion of the Administrator, in accordance with a cashless exercise program established with a securities brokerage firm, and approved by the Administrator; or (e) at the discretion of the Administrator, by any combination of (a), (b), (c) and (d) above; or (f) at the discretion of the Administrator, by payment of such other lawful consideration as the Administrator may determine.

The Company shall then reasonably promptly deliver the Shares as to which such Option was exercised to the Participant (or to the Participant's Survivors, as the case may be). In determining what constitutes "reasonably promptly," it is expressly understood that the issuance and delivery of the Shares may be delayed by the Company in order to comply with any law or regulation which requires the Company to take any action with respect to the Shares prior to their issuance. The Shares shall, upon delivery, be fully paid, non-assessable Shares.

10. ACCEPTANCE OF STOCK GRANTS AND STOCK-BASED AWARDS AND ISSUE OF SHARES.

Any Stock Grant or Stock-Based Award requiring payment of a purchase price for the Shares as to which such Stock Grant or Stock-Based Award is being granted shall be made (a) in United States dollars in cash or by check; or (b) at the discretion of the Administrator, through delivery of Shares (held for such period if and to the extent required to avoid negative accounting treatment) having a Fair Market Value equal as of the date of payment to the purchase price of the Stock Grant or Stock-Based Award; or (c) at the discretion of the Administrator, by any combination of (a) and (b) above; or (d) at the discretion of the Administrator, by payment of such other lawful consideration as the Administrator may determine.

The Company shall when required by the applicable Agreement, reasonably promptly deliver the Shares as to which such Stock Grant or Stock-Based Award was made to the Participant (or to the Participant's Survivors, as the case may be), subject to any escrow provision set forth in the applicable Agreement. In determining what constitutes "reasonably promptly," it is expressly understood that the issuance and delivery of the Shares may be delayed by the Company in order to comply with any law or regulation which requires the Company to take any action with respect to the Shares prior to their issuance.

11. RIGHTS AS A SHAREHOLDER.

No Participant to whom a Stock Right has been granted shall have rights as a shareholder with respect to any Shares covered by such Stock Right, except after due exercise of an Option or issuance of Shares as set forth in any Agreement, tender of the aggregate exercise or purchase price, if any, for the Shares being purchased and registration of the Shares in the Company's share register in the name of the Participant.

12. ASSIGNABILITY AND TRANSFERABILITY OF STOCK RIGHTS.

By its terms, a Stock Right granted to a Participant shall not be transferable by the Participant other than (a) by will or by the laws of descent and distribution, or (b) as approved by the Administrator in its discretion and set forth in the applicable Agreement provided that no Stock Right may be transferred by a Participant for value. The designation of a beneficiary of a Stock Right by a Participant, with the prior approval of the Administrator and in such form as the Administrator shall prescribe, shall not be deemed a transfer prohibited by this Paragraph 12. Except as provided above, during the Participant's lifetime a Stock Right shall only be exercisable by or issued to such Participant (or his or her legal representative) and shall not be assigned, pledged or hypothecated in any way (whether by operation of law or otherwise) and shall not be subject to execution, attachment or similar process. Any attempted transfer, assignment, pledge, hypothecation or other disposition of any Stock Right or of any rights granted thereunder contrary to the provisions of this Plan, or the levy of any attachment or similar process upon a Stock Right, shall be null and void.

13. EFFECT ON OPTIONS OF TERMINATION OF SERVICE OTHER THAN FOR CAUSE OR DEATH OR DISABILITY.

Except as otherwise provided in a Participant's Option Agreement in the event of a termination of service with the Company or an Affiliate before the Participant has exercised an Option, the following rules apply:

(a) A Participant who ceases to be an employee, director or consultant of the Company or of an Affiliate for any reason other than termination for Cause, Disability, or death (for which events there are special rules in Paragraphs 14, 15, and 16, respectively) may exercise any Option granted to him or her to the extent that the Option is exercisable on the date of such termination of service, but only within such term as the Administrator has designated in a Participant's Option Agreement.

(b) The provisions of this Paragraph 13, and not the provisions of Paragraphs 15 or 16, shall apply to a Participant who subsequently becomes Disabled or dies after the termination of employment, director status or consultancy; provided, however, in the case of a Participant's Disability or death within three months after the termination of employment, director status or consultancy, the Participant or the Participant's Survivors may exercise the Option within one year after the date of the Participant's termination of service, but in no event after the date of expiration of the term of the Option.

(c) Notwithstanding anything herein to the contrary, if subsequent to a Participant's termination of employment, termination of director status or termination of consultancy, but prior to the exercise of an Option, the Administrator determines that, either prior or subsequent to the Participant's termination, the Participant engaged in conduct which would constitute Cause, then such Participant shall forthwith cease to have any right to exercise any Option.

(d) A Participant to whom an Option has been granted under the Plan who is absent from the Company or an Affiliate because of temporary disability (any disability other than a Disability as defined in Paragraph 1 hereof), or who is on leave of absence for any purpose, shall not, during the period of any such absence, be deemed, by virtue of such absence alone, to have terminated such Participant's employment, director status or consultancy with the Company or with an Affiliate, except as the Administrator may otherwise expressly provide.

(e) Except as required by law or as set forth in a Participant's Option Agreement, Options granted under the Plan shall not be affected by any change of a Participant's status within or among the Company and any Affiliates, so long as the Participant continues to be an employee, director or consultant of the Company or any Affiliate.

14. EFFECT ON OPTIONS OF TERMINATION OF SERVICE FOR CAUSE.

Except as otherwise provided in a Participant's Option Agreement, the following rules apply if the Participant's service with the Company or an Affiliate is terminated for Cause prior to the time that all his or her outstanding Options have been exercised:

(a) All outstanding and unexercised Options as of the time the Participant is notified his or her service is terminated for Cause will immediately be forfeited.

(b) Cause is not limited to events which have occurred prior to a Participant's termination of service, nor is it necessary that the Administrator's finding of Cause occur prior to termination. If the Administrator determines, subsequent to a Participant's termination of service but prior to the exercise of an Option, that either prior or subsequent to the Participant's termination the Participant engaged in conduct which would constitute Cause, then the right to exercise any Option is forfeited.

15. EFFECT ON OPTIONS OF TERMINATION OF SERVICE FOR DISABILITY.

Except as otherwise provided in a Participant's Option Agreement:

(a) A Participant who ceases to provide services of the Company or of an Affiliate by reason of Disability may exercise any Option granted to such Participant to the extent that the Option has become exercisable but has not been exercised on the date of the Participant's termination of service due to Disability;

(b) In the event rights to exercise the Option accrue periodically, the Option will become exercisable on the date of the Participant's termination of service due to Disability to the extent of a pro rata portion through the date of the Participant's termination of service due to Disability of any additional vesting rights that would have accrued on the next vesting date had the Participant not become Disabled. The proration shall be based upon the number of days accrued in the current vesting period prior to the date of the Participant's termination of service due to Disability;

(c) A Disabled Participant may exercise the Option only within the period ending one year after the date of the Participant's termination of service due to Disability, notwithstanding that the Participant might have been able to exercise the Option as to some or all of the Shares on a later date if the Participant had not been terminated due to Disability or, if earlier, within the originally prescribed term of the Option; and

(d) The Administrator shall make the determination both of whether Disability has occurred and the date of its occurrence (unless a procedure for such determination is set forth in another agreement between the Company and such Participant, in which case such procedure shall be used for such determination). If requested, the Participant shall be examined by a physician selected or approved by the Administrator, the cost of which examination shall be paid for by the Company.

16. EFFECT ON OPTIONS OF TERMINATION OF SERVICE DUE TO DEATH.

Except as otherwise provided in a Participant's Option Agreement:

(a) In the event of a termination of a Participant's service due to the death of such Participant, such Option may be exercised by the Participant's Survivors to the extent that the Option has become exercisable but has not been exercised on the date of death;

(b) In the event rights to exercise the Option accrue periodically, the Option will become exercisable on the date of death to the extent of a pro rata portion through the date of death of any additional vesting rights that would have accrued on the next vesting date had the Participant not died. The proration shall be based upon the number of days accrued in the current vesting period prior to the Participant's date of death; and

(c) If the Participant's Survivors wish to exercise the Option, they must take all necessary steps to exercise the Option within one year after the date of death of such Participant, notwithstanding that the decedent might have been able to exercise the Option as to some or all of the Shares on a later date if he or she had not died or, if earlier, within the originally prescribed term of the Option.

17. EFFECT ON STOCK GRANTS AND STOCK-BASED AWARDS OF TERMINATION OF SERVICE.

In the event of a termination of service with the Company or an Affiliate for any reason before the Participant has accepted a Stock Grant or Stock-Based Award and paid the purchase price, if required, such grant shall terminate.

For purposes of this Paragraph 17 and Paragraph 18 below, a Participant to whom a Stock Grant or a Stock-Based Award has been issued under the Plan who is absent from work with the Company or with an Affiliate because of temporary disability (any disability other than a Disability as defined in Paragraph 1 hereof), or who is on leave of absence for any purpose, shall not, during the period of any such absence, be deemed, by virtue of such absence alone, to have terminated such Participant's employment, director status or consultancy with the Company or with an Affiliate, except as the Administrator may otherwise expressly provide.

In addition, for purposes of this Paragraph 17 and Paragraph 18 below, any change of employment or other service within or among the Company and any Affiliates shall not be treated as a termination of employment, director status or consultancy so long as the Participant continues to be an Employee, director or Consultant of the Company or any Affiliate.

18. EFFECT ON STOCK GRANTS AND STOCK-BASED AWARDS OF TERMINATION OF SERVICE OTHER THAN FOR CAUSE, DEATH OR DISABILITY.

Except as otherwise provided in a Participant's Agreement, in the event of a termination of service for any reason, other than termination for Cause, death or Disability (for which there are special rules in Paragraphs 19, 20, and 21 below), before all forfeiture provisions or Company rights of repurchase shall have lapsed, then the Company shall have the right to cancel or repurchase that number of Shares subject to a Stock Grant or Stock-Based Award as to which the Company's forfeiture or repurchase rights have not lapsed.

19. EFFECT ON STOCK GRANTS AND STOCK-BASED AWARDS OF TERMINATION OF SERVICE FOR CAUSE.

Except as otherwise provided in a Participant's Agreement, the following rules apply if the Participant's service with the Company or an Affiliate is terminated for Cause:

(a) All Shares subject to any Stock Grant or Stock-Based Award that remain subject to forfeiture provisions or as to which the Company shall have a repurchase right shall be immediately forfeited to the Company as of the time the Participant is notified his or her service is terminated for Cause.

(b) Cause is not limited to events which have occurred prior to a Participant's termination of service, nor is it necessary that the Administrator's finding of Cause occur prior to termination. If the Administrator determines, subsequent to a Participant's termination of service, that either prior or subsequent to the Participant's termination the Participant engaged in conduct which would constitute Cause, then all Shares subject to any Stock Grant or Stock-Based Award that remained subject to forfeiture provisions or as to which the Company had a repurchase right on the date of termination shall be immediately forfeited to the Company.

20. EFFECT ON STOCK GRANTS AND STOCK-BASED AWARDS OF TERMINATION OF SERVICE FOR DISABILITY.

Except as otherwise provided in a Participant's Agreement, the following rules apply if a Participant ceases to provide services to the Company or of an Affiliate by reason of Disability: to the extent the forfeiture provisions or the Company's rights of repurchase have not lapsed on the date of Disability, they shall lapse; provided, however, that in the event such forfeiture provisions or rights of repurchase lapse periodically, such provisions or rights shall lapse to the extent of a pro rata portion of the Shares subject to such Stock Grant or Stock-Based Award through the date of Disability as would have lapsed had the Participant not become Disabled. The proration shall be based upon the number of days accrued prior to the date of Disability.

The Administrator shall make the determination both as to whether Disability has occurred and the date of its occurrence (unless a procedure for such determination is set forth in another agreement between the Company and such Participant, in which case such procedure shall be used for such determination). If requested, the Participant shall be examined by a physician selected or approved by the Administrator, the cost of which examination shall be paid for by the Company.

21. EFFECT ON STOCK GRANTS AND STOCK-BASED AWARDS OF TERMINATION OF SERVICE DUE TO DEATH.

Except as otherwise provided in a Participant's Agreement, the following rules apply in the event of the termination of a Participant's service to the Company or of an Affiliate due to such Participant's death: to the extent the forfeiture provisions or the Company's rights of repurchase have not lapsed on the date of death, they shall lapse; provided, however, that in the event such forfeiture provisions or rights of repurchase lapse periodically, such provisions or rights shall lapse to the extent of a pro rata portion of the Shares subject to such Stock Grant or Stock-Based Award through the date of death as would have lapsed had the Participant not died. The proration shall be based upon the number of days accrued prior to the Participant's date of death.

22. DISSOLUTION OR LIQUIDATION OF THE COMPANY.

Upon the dissolution or liquidation of the Company, all Options granted under this Plan which as of such date shall not have been exercised and all Stock Grants and Stock-Based Awards which have not been accepted, to the extent required under the applicable Agreement, will terminate and become null and void; provided, however, that if the rights of a Participant or a Participant's Survivors have not otherwise terminated and expired, the Participant or the Participant's Survivors will have the right immediately prior to such dissolution or liquidation to exercise or accept any Stock Right to the extent that the Stock Right is exercisable or subject to acceptance as of the date immediately prior to such dissolution or liquidation. Upon the dissolution or liquidation of the Company, any outstanding Stock-Based Awards shall immediately terminate unless otherwise determined by the Administrator or specifically provided in the applicable Agreement.

23. ADJUSTMENTS.

Upon the occurrence of any of the following events, a Participant's rights with respect to any Stock Right granted to him or her hereunder shall be adjusted as hereinafter provided, unless otherwise specifically provided in a Participant's Agreement:

(a) *Stock Dividends and Stock Splits.* If (i) the shares of Common Stock shall be subdivided or combined into a greater or smaller number of shares or if the Company shall issue any shares of Common Stock as a stock dividend on its outstanding Common Stock, or (ii) additional shares or new or different shares or other securities of the Company or other non-cash assets are distributed with respect to such shares of Common Stock, each Stock Right and the number of Shares deliverable thereunder shall be appropriately increased or decreased proportionately, and appropriate adjustments shall be made including, in the exercise or purchase price per share to reflect such events. The number of Shares subject to the limitation in Paragraph 3(a) shall also be proportionately adjusted upon the occurrence of such events.

(b) *Corporate Transactions*. Upon consummation of a transaction where the Company is consolidated with or acquired by another entity in a merger or consolidation, or where the Company sells all or substantially all of the Company's assets, other than a transaction to merely change the state of incorporation (a "***Corporate Transaction***"), the Administrator or the board of directors of any entity assuming the obligations of the Company hereunder (the "***Successor Board***"), shall, as to outstanding Options, either (i) make appropriate provision for the continuation of such Options by substituting on an equitable basis for the Shares then subject to such Options either the consideration payable with respect to the outstanding shares of Common Stock in connection with the Corporate Transaction or securities of any successor or acquiring entity; or (ii) upon written notice to the Participants, provide that such Options must be exercised within a specified number of days of the date of such notice, at the end of which period such Options which have not yet been exercised shall terminate (all Options shall for purposes of this clause (ii) be made fully vested and exercisable immediately prior to their termination); or (iii) terminate such Options in exchange for payment of an amount equal to the consideration payable upon consummation of such Corporate Transaction to a holder of the number of Shares into which such Option would have been exercisable (all Options shall for purposes of this clause (iii) be made fully vested and immediately exercisable immediately prior to their termination) less the aggregate exercise price thereof. For purposes of determining the payments to be made pursuant to Subclause (iii) above, in the case of a Corporate Transaction the consideration for which, in whole or in part, is other than cash, the consideration other than cash shall be valued at the fair value thereof as determined in good faith by the Board of Directors.

Upon consummation of a Corporate Transaction, with respect to outstanding Stock Grants, the Administrator or the Successor Board, shall either (i) make appropriate provision for the continuation of such Stock Grants on the same terms and conditions by substituting on an equitable basis for the Shares then subject to such Stock Grants the securities of any successor or acquiring entity in the Corporate Transaction or (ii) provide that, upon consummation of the Corporate Transaction, each outstanding Stock Grant shall be terminated in exchange for payment of an amount equal to the consideration payable upon consummation of such Corporate Transaction to a holder of the number of shares of Common Stock comprising such Stock Grant (all forfeiture and repurchase rights being waived upon such Corporate Transaction).

In taking any of the actions permitted under this Subparagraph 23(b), the Administrator shall not be obligated by the Plan to treat all Stock Rights, all Stock Rights held by a Participant, or all Stock Rights of the same type, identically.

(c) *Recapitalization or Reorganization.* In the event of a recapitalization or reorganization of the Company, other than a Corporate Transaction, pursuant to which securities of the Company or of another corporation are issued with respect to the outstanding shares of Common Stock, a Participant upon exercising an Option or accepting a Stock Grant after the recapitalization or reorganization shall be entitled to receive for the price paid upon such exercise or acceptance, if any, the number of replacement securities which would have been received if such Option had been exercised or Stock Grant accepted prior to such recapitalization or reorganization.

(d) *Adjustments to Stock-Based Awards.* Upon the happening of any of the events described in Subparagraphs 23(a), 23(b) or 23(c) above, any outstanding Stock-Based Award shall be appropriately adjusted to reflect the events described in such Subparagraphs. The Administrator or the Successor Board shall determine the specific adjustments to be made under this Paragraph 23, including, but not limited to the effect of any Corporate Transaction and Change of Control and, subject to Paragraph 4, its determination shall be conclusive.

(e) *Modification of Options.* Notwithstanding the foregoing, any adjustments made pursuant to Subparagraphs 23(a), 23(b) or 23(c) above with respect to Options shall be made only after the Administrator determines whether such adjustments would cause any adverse tax consequences for the holders of Options, including, but not limited to, pursuant to Section 409A of the Code. If the Administrator determines that such adjustments made with respect to Options would cause adverse tax consequence, it may refrain from making such adjustments, unless the holder of an Option specifically agrees in writing that such adjustment be made and such writing indicates that the holder has full knowledge of the consequences of such adjustment on his or her income tax treatment with respect to the Option.

(f) *Change of Control.* In the event of either:

(i) a Corporate Transaction that also constitutes a Change of Control, where outstanding Options are assumed or substituted in accordance
with the first paragraph of Subparagraph 23(b) clause (i) above and, with respect to Stock Grants, in accordance with the second
paragraph of Subparagraph 23(b) clause (i); or

(ii) a Change of Control that does not also constitute a Corporate Transaction,

if within six (6) months after the date of such Change of Control, (A) a Participant's service is terminated by the Company or an Affiliate for any reason other than Cause; or (B) a Participant terminates his or her service as a result of being required to change the principal location where he or she renders services to a location more than 50 miles from his or her location of employment or consultancy immediately prior to the Change of Control; or (C) a Participant terminates his or her service after a material adverse change in a Participant's duties, authority or responsibilities which causes such Participant's position with the Company to become of significantly less responsibility or authority than such Participant's position was immediately prior to the Change of Control; provided, in each case of clauses (B) and (C), such Participant provides written notice of such event to the Company within 30 days of the initial occurrence of such event, the Company fails to cure such event within 30 days from receipt of such written notice, and such Participant actually terminates employment at the end of the Company's 30-day cure period;

*then* all of such Participant's (1) Options outstanding under the Plan shall become fully vested and immediately exercisable as of the date of termination of such Participant's service, unless in any such case the Option has otherwise expired or been terminated pursuant to its terms or the terms of the Plan and (2) any forfeiture or repurchase rights of the Company with respect to outstanding Stock Grants that have not lapsed or expired prior to such Change of Control shall lapse and terminate as of the date of termination of such Participant's service.

24. ISSUANCES OF SECURITIES.

Except as expressly provided herein, no issuance by the Company of shares of stock of any class, or securities convertible into shares of stock of any class, shall affect, and no adjustment by reason thereof shall be made with respect to, the number or price of shares subject to Stock Rights. Except as expressly provided herein, no adjustments shall be made for dividends paid in cash or in property (including without limitation, securities) of the Company prior to any issuance of Shares pursuant to a Stock Right.

25. FRACTIONAL SHARES.

No fractional shares shall be issued under the Plan, and the person exercising a Stock Right shall receive from the Company cash in lieu of such fractional shares equal to the Fair Market Value thereof.

26. WITHHOLDING.

(a) In the event that any federal, state, or local income taxes, employment taxes, Federal Insurance Contributions Act withholdings or other amounts are required by applicable law or governmental regulation to be withheld from the Participant's salary, wages or other remuneration in connection with a Stock Right or Shares under the Plan or for any other reason required by law, the Company may withhold from the Participant's compensation, if any, or may require that the Participant advance in cash to the Company, or to any Affiliate of the Company which employs or employed the Participant, the amount of such withholdings unless a different withholding arrangement, including the use of Shares or a promissory note, is authorized by the Administrator (and permitted by law). For purposes hereof, the fair market value of the shares withheld for purposes of payroll withholding shall be determined in the manner set forth under the definition of Fair Market Value provided in Paragraph 1 above, as of the most recent practicable date prior to the date of exercise. If the Fair Market Value of the shares withheld is less than the amount of payroll withholdings required, the Participant may be required to advance the difference in cash to the Company or the Affiliate employer. The Administrator in its discretion may condition the exercise of an Option for less than the then Fair Market Value on the Participant's payment of such additional withholding.

(b) The maximum number of Shares that may be withheld from any Stock Right to satisfy any federal, state, or local tax withholding requirements upon the exercise, vesting, or lapse of restrictions applicable to any Stock Right or payment of Shares pursuant to such Stock Right, as applicable, may not exceed such number of Shares having a Fair Market Value equal to the minimum statutory amount required by the Company or the applicable Affiliate to be withheld and paid to any such federal, state, or local taxing authority with respect to such Stock Right; provided, however, for so long as Accounting Standards Update 2016-09 or a similar rule remains in effect, the Administrator has full discretion to choose, or to allow a Participant to elect, to withhold a number of Shares having an aggregate Fair Market Value that is greater than the applicable minimum required statutory withholding obligation (but such withholding may in no event be in excess of the maximum required statutory withholding amount(s) in such Participant's relevant tax jurisdiction).

27. EFFECTIVE DATE; TERMINATION OF THE PLAN.

The Plan is effective as of June 16, 2025. The Plan will terminate on June 16, 2035, the date which is ten years from the date of its adoption by the Board of Directors. The Plan may be terminated at an earlier date by vote of the Board of Directors; provided, however, that any such earlier termination shall not affect any Agreements executed prior to the effective date of such termination. Termination of the Plan shall not affect any Stock Rights theretofore granted.

28. AMENDMENT OF THE PLAN AND AGREEMENTS; NO REPRICING.

(a) The Plan may be amended by the Administrator, including, without limitation, to the extent necessary to qualify the Shares issuable under the Plan for listing on any national securities exchange or quotation in any national automated quotation system of securities dealers; provided that any amendment approved by the Administrator which the Administrator determines is of a scope that requires shareholder approval shall be subject to obtaining such shareholder approval.

(b) Other than as set forth in Paragraph 23 of the Plan, the Administrator may not without shareholder approval reduce the exercise price of an Option or cancel any outstanding Option in exchange for a replacement option having a lower exercise price, any Stock Grant, any other Stock-Based Award or for cash. In addition, the Administrator may not take any other action that is considered a direct or indirect "repricing" for purposes of the shareholder approval rules of the applicable securities exchange or inter-dealer quotation system on which the Shares are listed, including any other action that is treated as a repricing under generally accepted accounting principles.

(c) Any modification or amendment of the Plan shall not, without the consent of a Participant, adversely affect his or her rights under a Stock Right previously granted to him or her. With the consent of the Participant affected, the Administrator may amend outstanding Agreements in a manner which may be adverse to the Participant but which is not inconsistent with the Plan. In the discretion of the Administrator, outstanding Agreements may be amended by the Administrator in a manner which is not adverse to the Participant. Nothing in this Paragraph 28 shall limit the Administrator's authority to take any action permitted pursuant to Paragraph 23.

(d) Stock Rights granted prior to the applicable amendment and restatement date shall be subject to the Plan as further amended and restated, except to the extent such amendment would adversely affect the Participant's rights under such Stock Right.

29. EMPLOYMENT OR OTHER RELATIONSHIP.

Nothing in this Plan or any Agreement shall be deemed to prevent the Company or an Affiliate from terminating the employment, consultancy or director status of a Participant, nor to prevent a Participant from terminating his or her own employment, consultancy or director status or to give any Participant a right to be retained in employment or other service by the Company or any Affiliate for any period of time.

30. SECTION 409A.

If a Participant is a "specified employee" as defined in Section 409A of the Code (and as applied according to procedures of the Company and its Affiliates) as of his separation from service, to the extent any payment under this Plan or pursuant to the grant of a Stock Right constitutes deferred compensation (after taking into account any applicable exemptions from Section 409A of the Code), and to the extent required by Section 409A of the Code, no payments due under this Plan or pursuant to a Stock Right may be made until the earlier of: (a) the first day of the seventh month following the Participant's separation from service, or (b) the Participant's date of death; provided, however, that any payments delayed during this six (6)-month period shall be paid in the aggregate in a lump sum, without interest, on the first day of the seventh month following the Participant's separation from service.

The Administrator shall administer the Plan with a view toward ensuring that Stock Rights under the Plan that are subject to Section 409A of the Code comply with the requirements thereof and that Options under the Plan be exempt from the requirements of Section 409A of the Code, but neither the Administrator nor any member of the Board of Directors, nor the Company nor any of its Affiliates, nor any other person acting hereunder on behalf of the Company, the Administrator or the Board of Directors shall be liable to a Participant or any Survivor by reason of the acceleration of any income, or the imposition of any additional tax or penalty, with respect to a Stock Right, whether by reason of a failure to satisfy the requirements of Section 409A of the Code or otherwise.

31. SECTION 280G.

If any payment or benefit a Participant would receive under this Plan, when combined with any other payment or benefit such Participant receives pursuant to a change of control (as defined for purposes of Section 280G of the Code) (for purposes of this Paragraph, a "***Payment***") would: (a) constitute a "parachute payment" within the meaning of Section 280G of the Code; and (b) but for this sentence, be subject to the excise tax imposed by Section 4999 of the Code (the "***Excise Tax***"), then such Payment shall be either: (x) the full amount of such Payment; or (y) such lesser amount as would result in no portion of the Payment being subject to the Excise Tax, whichever of the foregoing amounts, taking into account the applicable federal, state, and local employments taxes, income taxes, and the Excise Tax, results in such Participant's receipt, on an after-tax basis, of the greater amount of the Payment, notwithstanding that all or some portion of the Payment may be subject to the Excise Tax.

Except as required by Section 409A of the Code or to the extent that Section 409A of the Code permits discretion, the Administrator shall have the right, in the Administrator's sole discretion, to designate those payments or benefits that should be reduced or eliminated so as to avoid having such payments or benefits be considered a parachute payment; provided, however, to the extent any payment or benefit constitutes deferred compensation under Section 409A of the Code, in order to comply with Section 409A of the Code, the Administrator shall instead accomplish such reduction by first reducing or eliminating any cash payments (with the payments to be made furthest in the future being reduced first), then by reducing or eliminating any accelerated vesting of Stock Rights subject to performance-based vesting, then by reducing or eliminating any accelerated vesting of Options, then by reducing or eliminating any accelerated vesting of remaining Stock Grants or Stock-Based Grants, then by reducing or eliminating any other remaining parachute payments.

32. INDEMNITY.

Neither the Board of Directors nor the Administrator, nor any members of either, nor any employees of the Company or any parent, subsidiary, or other Affiliate, shall be liable for any act, omission, interpretation, construction or determination made in good faith in connection with their responsibilities with respect to this Plan, and the Company hereby agrees to indemnify the members of the Board of Directors, the members of the Committee, and the employees of the Company and its parent or subsidiaries in respect of any claim, loss, damage, or expense (including reasonable counsel fees) arising from any such act, omission, interpretation, construction or determination to the full extent permitted by law.

33. CLAWBACK.

Notwithstanding anything to the contrary contained in this Plan, any compensation from any Stock Right (whether or not settled and whether subject to time-based or performance-based vesting requirements) granted under the Plan shall be subject to any clawback or recoupment policies or arrangements that the Company has in place from time to time, and the Administrator may, to the extent permitted, and shall, to the extent required, by applicable law, stock exchange rules or Company policy or arrangement, cancel or require forfeiture or reimbursement of any Stock Right (whether or not vested) granted to a Participant (and any benefits derived therefrom).

34. GOVERNING LAW.

This Plan shall be construed and enforced in accordance with the law of the State of Delaware, other than any conflicts or choice of law rule or principle that might otherwise refer construction or enforcement to the substantive laws of any other jurisdiction.

## Exhibit 99.2

**Exhibit 99.2**

**MADRIGAL PHARMACEUTICALS, INC.**<br> **2025 INDUCEMENT STOCK PLAN** 

**NON-QUALIFIED STOCK OPTION AGREEMENT<br> GRANT NOTICE**

1. **Name of Participant:** 

2. **Grant Date of the Option <br> (the "Grant Date"):** 

3. **Number of Shares of Common Stock Covered by the Option:** 

4. **Purchase Price Per Share of Common Stock:** 

5. **Vesting Commencement Date:** 

6. **Vesting of Award:** Subject to the Participant's continuous employment or other service relationship with or to the Company or any of its Affiliates as an employee, director, and/or consultant from the Grant Date through each of the following applicable dates (each such date, a "**Vesting Date** "), the Option shall vest with respect to twenty-five percent (25%) of the "Number of Shares of Common Stock Covered by the Option" above on the first anniversary of the "Vesting Commencement Date" above, then six and one-quarter percent (6.25%) of the "Number of Shares of Common Stock Covered by the Option" above on each quarterly anniversary thereafter. Any terms used and not defined herein have the meanings ascribed to such terms in the Madrigal Pharmaceuticals, Inc. 2025 Inducement Stock Plan (as it may be amended and/or restated from time to time, the "**Plan** ").

**By signing this Grant Notice or by electronic acknowledgment of this Grant Notice, the Participant acknowledges receipt of and agrees to all the terms and conditions described in this Non-Qualified Stock Option Agreement Grant Notice, the attached Non-Qualified Stock Option Agreement, and the Plan. The Participant acknowledges that the Participant has carefully reviewed the Plan and agrees that the Plan will control in the event any provision of the Agreement should appear to be inconsistent with the Plan.**

---

| |
|:---|
| **MADRIGAL PHARMACEUTICALS, INC.** |
| By: |
| Name: |
| Title: |
| **PARTICIPANT** |
| **ATTACHMENT**: Non-Qualified Stock Option Agreement |

---

**MADRIGAL PHARMACEUTICALS, INC.<br> 2025 INDUCEMENT STOCK PLAN** 

**NON-QUALIFIED STOCK OPTION AGREEMENT**

This NON-QUALIFIED STOCK OPTION AGREEMENT (the "**Agreement**") is made as of the "Grant Date" set forth in the Non-Qualified Stock Option Agreement Grant Notice ("**Grant Notice**") between MADRIGAL PHARMACEUTICALS, INC. (the "**Company**"), a Delaware corporation, and the individual whose name appears on the Grant Notice (the "**Participant**").

WHEREAS, the Company has adopted the Madrigal Pharmaceuticals, Inc. 2025 Inducement Stock Plan (as it may be amended and/or restated from time to time, the "**Plan**") to promote the interests of the Company by providing an incentive for prospective officers and employees who are not currently employed by the Company and its Affiliates to accept employment with the Company or an Affiliate;

WHEREAS, pursuant to the provisions of the Plan, the Company desires to grant to the Participant an option to purchase shares of the Company's common stock, $0.0001 par value per share ("**Shares**"), in accordance with the provisions of the Plan, all on the terms and conditions hereinafter set forth;

WHEREAS, the option has been granted as an inducement pursuant to Rule 5635(c)(4) of the Marketplace Rules of NASDAQ Stock Market, Inc.; and

WHEREAS, the Company and the Participant understand and agree that any terms used and not defined herein have the meanings ascribed to such terms in the Plan.

NOW, THEREFORE, in consideration of the promises and the mutual covenants contained herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto hereby agree as follows:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. <u>GRANT OF OPTION.</u> 

The Company hereby grants to the Participant, as of the Grant Date, the right and option to purchase all or any part of the aggregate number of Shares set forth in the Grant Notice, on the terms and conditions and subject to all the limitations set forth herein, under United States securities and tax laws, in the Grant Notice, and in the Plan, which is incorporated herein by reference. The Participant acknowledges receipt of a copy of the Plan.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. <u>PURCHASE PRICE.</u> 

The purchase price of the Shares covered by the Option shall be the Purchase Price set forth in the Grant Notice, subject to adjustment, as provided in the Plan, in the event of a stock split, reverse stock split or other events affecting the holders of Shares. Payment shall be made in accordance with Section 9 of the Plan.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3. <u>EXERCISABILITY OF OPTION.</u> 

Subject to the terms and conditions set forth in this Agreement and the Plan, the Option granted hereby shall become vested and exercisable as set forth in the Grant Notice. Notwithstanding the foregoing, the Option shall become vested and exercisable in accordance with the terms and conditions set forth in the Plan.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4. <u>TERM OF OPTION.</u> 

The Option shall terminate ten years from the Grant Date, but shall be subject to earlier termination as provided herein or in the Plan.

If the Participant ceases to provide services to the Company or of an Affiliate (for any reason other than the death or Disability of the Participant or termination of the Participant's service for "cause" (as defined in the Plan)), the Option may be exercised, if it has not previously terminated, within three months after the date the Participant ceases to provide services to the Company or of an Affiliate, or within the originally prescribed term of the Option, whichever is earlier, but may not be exercised thereafter. In such event, the Option shall be exercisable only to the extent that the Option has become exercisable and is in effect at the date of such cessation of service.

Notwithstanding the foregoing, in the event of the Participant's Disability or death within three months after the termination of service, the Participant or the Participant's Survivors may exercise the Option within one year after the date of the Participant's termination of service, but in no event after the date of expiration of the term of the Option.

In the event the Participant's service is terminated by the Company or by an Affiliate for Cause (as defined in the Plan), the Participant's right to exercise any unexercised portion of this Option shall cease immediately as of the time the Participant is notified his or her service is terminated for Cause and this Option shall thereupon terminate. Notwithstanding anything herein to the contrary, if subsequent to the Participant's termination, but prior to the exercise of the Option, the Board of Directors of the Company determines that, either prior or subsequent to the Participant's termination, the Participant engaged in conduct which would constitute Cause, then the Participant shall immediately cease to have any right to exercise the Option, and this Option shall thereupon terminate.

In the event of the Disability of the Participant, as determined in accordance with the Plan, the Option shall be exercisable within one year after the Participant's termination of service or, if earlier, within the term originally prescribed by the Option. In such event, the Option shall be exercisable:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) to the extent that the Option has become exercisable but has not been exercised as of the date of Disability;
and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) in the event rights to exercise the Option accrue periodically, to the extent of a pro rata portion through
the date of Disability of any additional vesting rights that would have accrued on the next Vesting Date had the Participant not become
Disabled. The proration shall be based upon the number of days accrued in the current vesting period prior to the date of Disability.

In the event of the death of the Participant while providing services to the Company or of an Affiliate, the Option shall be exercisable by the Participant's Survivors within one year after the date of death of the Participant or, if earlier, within the originally prescribed term of the Option. In such event, the Option shall be exercisable:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(x) to the extent that the Option has become exercisable but has not been exercised as of the date of death;
and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(y) in the event rights to exercise the Option accrue periodically, to the extent of a pro rata portion through
the date of death of any additional vesting rights that would have accrued on the next Vesting Date had the Participant not died. The
proration shall be based upon the number of days accrued in the current vesting period prior to the Participant's date of death.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5. <u>METHOD OF EXERCISING OPTION.</u> 

Subject to the terms and conditions of this Agreement, the Option may be exercised by written notice to the Company or its designee, in substantially the form prescribed by the Company or its designees. Such notice shall state the number of Shares with respect to which the Option is being exercised and shall be signed by the person exercising the Option. Payment of the Purchase Price for such Shares shall be made in accordance with Section 9 of the Plan. The Company shall deliver such Shares as soon as practicable after the notice shall be received; provided, however, that the Company may delay issuance of such Shares until completion of any action or obtaining of any consent, which the Company deems necessary under any applicable law (including, without limitation, state securities or "blue sky" laws). The Shares as to which the Option shall have been so exercised shall be registered in the Company's share register in the name of the person so exercising the Option (or, if the Option shall be exercised by the Participant and if the Participant shall so request in the notice exercising the Option, shall be registered in the Company's share register in the name of the Participant and another person jointly, with right of survivorship) and shall be delivered as provided above to or upon the written order of the person exercising the Option. In the event the Option shall be exercised, pursuant to Section 4 hereof, by any person other than the Participant, such notice shall be accompanied by appropriate proof of the right of such person to exercise the Option. All Shares that shall be purchased upon the exercise of the Option as provided herein shall be fully paid and nonassessable.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6. <u>PARTIAL EXERCISE.</u> 

Exercise of this Option to the extent vested may be made in part at any time and from time to time within the above limits, except that no fractional share shall be issued pursuant to this Option.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7. <u>NON-ASSIGNABILITY.</u> 

The Option shall not be transferable by the Participant other than by will or by the laws of descent and distribution or pursuant to a qualified domestic relations order as defined by the Code or Title I of the Employee Retirement Income Security Act or the rules thereunder. However, the Participant, with the approval of the Administrator, may transfer the Option for no consideration to or for the benefit of the Participant's Immediate Family (as defined below and including, without limitation, to a trust for the benefit of the Participant's Immediate Family or to a partnership or limited liability company for one or more members of the Participant's Immediate Family), subject to such limits as the Administrator may establish, and the transferee shall remain subject to all the terms and conditions applicable to the Option prior to such transfer and each such transferee shall so acknowledge in writing as a condition precedent to the effectiveness of such transfer. Except as provided in the previous sentence, the Option shall be exercisable, during the Participant's lifetime, only by the Participant (or, in the event of legal incapacity or incompetency, by the Participant's guardian or representative) and shall not be assigned, pledged or hypothecated in any way (whether by operation of law or otherwise) and shall not be subject to execution, attachment or similar process. Any attempted transfer, assignment, pledge, hypothecation or other disposition of the Option or of any rights granted hereunder contrary to the provisions of this Section 7, or the levy of any attachment or similar process upon the Option shall be null and void. The term "Immediate Family" shall mean the Participant's spouse, former spouse, parents, children, stepchildren, adoptive relationships, sisters, brothers, nieces, nephews and grandchildren (and, for this purpose, shall also include the Participant).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8. <u>NO RIGHTS AS STOCKHOLDER UNTIL EXERCISE.</u> 

The Participant shall have no rights as a stockholder with respect to Shares subject to this Option until registration of the Shares in the Company's share register in the name of the Participant. Except as is expressly provided in the Plan with respect to certain changes in the capitalization of the Company, no adjustment shall be made for dividends or similar rights for which the record date is prior to the date of such registration.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;9. <u>ADJUSTMENTS.</u> 

The Plan contains provisions covering the treatment of Options in a number of contingencies such as stock splits and mergers. Provisions in the Plan for adjustment with respect to stock subject to Options and the related provisions with respect to successors to the business of the Company are hereby made applicable hereunder and are incorporated herein by reference.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10. <u>TAXES.</u> 

The Participant acknowledges that any income or other taxes due from him or her with respect to this Option or the Shares issuable pursuant to this Option shall be the Participant's responsibility.

The Participant agrees that the Company may withhold from the Participant's remuneration, if any, up to the maximum statutory amount of federal, state and local withholding taxes attributable to such amount that is considered compensation includable in such person's gross income. At the Company's discretion, the amount required to be withheld may be withheld in cash from such remuneration, or in kind from the Shares otherwise deliverable to the Participant on exercise of the Option. The Participant further agrees that, if the Company does not withhold an amount from the Participant's remuneration sufficient to satisfy the Company's income tax withholding obligation, the Participant will reimburse the Company on demand, in cash, for the amount under-withheld.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;11. <u>NO OBLIGATION TO MAINTAIN RELATIONSHIP.</u> 

The Company is not by the Plan or this Option obligated to continue the Participant's service relationship with the Company or of an Affiliate. The Participant acknowledges: (i) that the Plan is discretionary in nature and may be suspended or terminated by the Company at any time; (ii) that the grant of the Option is a one-time benefit which does not create any contractual or other right to receive future grants of options, or benefits in lieu of options; (iii) that all determinations with respect to any such future grants, including, but not limited to, the times when options shall be granted, the number of shares subject to each option, the option price, and the time or times when each option shall be exercisable, will be at the sole discretion of the Company; (iv) that the Participant's participation in the Plan is voluntary; (v) that the value of the Option is an extraordinary item of compensation which is outside the scope of the Participant's employment contract, if any; and (vi) that the Option is not part of normal or expected compensation for purposes of calculating any severance, resignation, redundancy, end of service payments, bonuses, long-service awards, pension or retirement benefits or similar payments.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;12. <u>NOTICES.</u> 

By accepting the Option, the Participant agrees that notices may be given to the Participant in writing either at the Participant's home or mailing address as shown in the records of the Company or an Affiliate or by electronic transmission (including e-mail or reference to a website or other URL) sent to the Participant through the normal process employed by the Company or the Affiliate, as applicable, for communicating electronically with its employees or other service providers.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13. <u>GOVERNING LAW.</u> 

This Agreement shall be construed and enforced in accordance with the law of the State of Delaware, without giving effect to the conflict of law principles thereof. For the purpose of litigating any dispute that arises under this Agreement, the parties hereby consent to exclusive jurisdiction in the Commonwealth of Pennsylvania and agree that such litigation shall be conducted in the courts of Montgomery County, Pennsylvania or the federal courts of the United States for the Eastern District of Pennsylvania.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;14. <u>BENEFIT OF AGREEMENT.</u> 

Subject to the provisions of the Plan and the other provisions hereof, this Agreement shall be for the benefit of and shall be binding upon the heirs, executors, administrators, successors and assigns of the parties hereto.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;15. <u>ENTIRE AGREEMENT.</u> 

This Agreement, together with the Grant Notice and the Plan, embodies the entire agreement and understanding between the parties hereto with respect to the subject matter hereof and supersedes all prior oral or written agreements and understandings relating to the subject matter hereof. No statement, representation, warranty, covenant or agreement not expressly set forth in this Agreement shall affect or be used to interpret, change or restrict the express terms and provisions of this Agreement, provided, however, in any event, this Agreement shall be subject to and governed by the Plan.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;16. <u>MODIFICATIONS AND AMENDMENTS.</u> 

The terms and provisions of this Agreement may be modified or amended as provided in the Plan.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;17. <u>WAIVERS AND CONSENTS.</u> 

Except as provided in the Plan, the terms and provisions of this Agreement may be waived, or consent for the departure therefrom granted, only by written document executed by the party entitled to the benefits of such terms or provisions. No such waiver or consent shall be deemed to be or shall constitute a waiver or consent with respect to any other terms or provisions of this Agreement, whether or not similar. Each such waiver or consent shall be effective only in the specific instance and for the purpose for which it was given, and shall not constitute a continuing waiver or consent.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;18. <u>DATA PRIVACY.</u> 

By entering into this Agreement, the Participant: (i) authorizes the Company and each Affiliate, and any agent of the Company or any Affiliate administering the Plan or providing Plan recordkeeping services, to disclose to the Company or any of its Affiliates such information and data as the Company or any such Affiliate shall request in order to facilitate the grant of options and the administration of the Plan; and (ii) authorizes the Company and each Affiliate to store and transmit such information in electronic form for the purposes set forth in this Agreement.

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## Exhibit 99.3

**Exhibit 99.3**

Non-Section 16 Officer Form

**MADRIGAL PHARMACEUTICALS, INC.<br> 2025 INDUCEMENT STOCK PLAN**

**RESTRICTED Stock Unit Award<br> Grant Notice**

1. **Name of Participant:** 

2. **Grant Date of the RSUs <br> (the "Grant Date"):** 

3. **Number of RSUs:** 

4. **Vesting of Award:** Subject to the Participant's continuous employment or other service relationship with or to the Company or any of its Affiliates as an employee, director, and/or consultant from the Grant Date through each of the following applicable dates (each such date, a "**Vesting Date** "), the RSUs shall vest twenty-five percent (25%) of the Number of RSUs above on each of the first, second, third, and fourth anniversaries of the Grant Date. Any terms used and not defined herein have the meanings ascribed to such terms in the Madrigal Pharmaceuticals, Inc. 2025 Inducement Stock Plan (as it has been and may be amended and/or restated from time to time, the "**Plan** ").

**By signing this Grant Notice or by electronic acknowledgment of this Grant Notice, the Participant acknowledges receipt of and agrees to all the terms and conditions described in this Restricted Stock Unit Award Grant Notice, the attached Restricted Stock Unit Agreement, and the Plan. The Participant acknowledges that the Participant has carefully reviewed the Plan and agrees that the Plan will control in the event any provision of the Agreement is inconsistent with the Plan.**

---

| |
|:---|
| **MADRIGAL PHARMACEUTICALS, INC.** |
| By: |
| Name: |
| Title: |
| **PARTICIPANT** |
| <br> **ATTACHMENT**: Restricted Stock Unit Agreement |

---

**MADRIGAL PHARMACEUTICALS, INC.<br> 2025 INDUCEMENT STOCK PLAN**

**RESTRICTED STOCK UNIT AGREEMENT**

This RESTRICTED STOCK UNIT AGREEMENT (the "**Agreement**") is made as of the "Grant Date" set forth in the Restricted Stock Unit Award Grant Notice ("**Grant Notice**") between MADRIGAL PHARMACEUTICALS, INC. (the "**Company**"), a Delaware corporation, and the individual whose name appears on the Grant Notice (the "**Participant**").

WHEREAS, the Company has adopted the Madrigal Pharmaceuticals, Inc. 2025 Inducement Stock Plan (as it has been and may be amended and/or restated from time to time, the "**Plan**") to promote the interests of the Company by providing an incentive for prospective officers and employees who are not currently employed by the Company and its Affiliates to accept employment with the Company or an Affiliate;

WHEREAS, pursuant to the provisions of the Plan, the Company desires to grant to the Participant restricted stock units ("**RSUs**") related to the Company's common stock, $0.0001 par value per share ("**Common Stock**"), in accordance with the provisions of the Plan, all on the terms and conditions hereinafter set forth;

WHEREAS, the RSUs have been granted as an inducement pursuant to Rule 5635(c)(4) of the Marketplace Rules of NASDAQ Stock Market, Inc.; and

WHEREAS, the Company and the Participant understand and agree that any terms used and not defined herein have the meanings ascribed to such terms in the Plan.

NOW, THEREFORE, in consideration of the promises and the mutual covenants contained herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto hereby agree as follows:

1. <u>Grant of Award</u>. The Company hereby grants to the Participant a Stock-Based Award for the
number of RSUs set forth in the Grant Notice (the "**Award** "). Each RSU represents a contingent entitlement of the
Participant to receive one share of Common Stock, on the terms and conditions and subject to all the limitations set forth herein, in
the Grant Notice, and in the Plan, which are incorporated herein by reference.

2. <u>Vesting of Award</u>.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a. Subject to the terms and conditions set forth in this Agreement and the Plan: (i) the Award shall
vest as set forth in the Grant Notice and is subject to the other terms and conditions of this Agreement and the Plan; and (ii) upon
vesting, the Participant shall be entitled to receive such number of shares of Common Stock equivalent to the number of such vested RSUs.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b. Notwithstanding anything to the contrary in the Grant Notice or this Agreement, any fractional Shares
resulting from the vesting schedule set forth in the Grant Notice will be rounded to the nearest whole Share and shall be rounded up or
down as necessary as of the last Vesting Date; provided, in all cases, the Participant cannot vest in more than the number of RSUs set
forth in the Grant Notice.

3. <u>Forfeiture of Unvested RSUs</u>.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a. Except as otherwise set forth in this Agreement, or a separate written agreement between Participant and
the Company, if the Participant ceases the Participant's continuous employment or other service relationship with or to the Company
or any of its Affiliates ()"**Termination**") for any reason, then all then-unvested RSUs shall automatically and immediately
be forfeited to the Company as of such Termination, and this Agreement and the Grant Notice shall automatically and immediately terminate
and be of no further force or effect.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b. For purposes of this Agreement, the Participant's continuous employment or other service relationship
with or to the Company or any of its Affiliates does not terminate when the Participant goes on a bona fide leave of absence that was
approved by the Administrator in writing, if the terms of the leave provide for continued service crediting, or when continued service
crediting is required by applicable law. The Participant's continuous employment or other service relationship with or to the Company
or any of its Affiliates terminates in any event when the approved leave ends unless the Participant immediately returns to active work.
The Administrator may determine, in its discretion, which leaves count for this purpose and when the Participant's continuous employment
or other service relationship with or to the Company or any of its Affiliates terminates for all purposes under the Plan in accordance
with the provisions of the Plan.

4. <u>Delivery of Award; Evidence of Issuance</u>. Delivery of the Shares represented by the Participant's
vested RSUs shall be made as soon as practicable after the applicable Vesting Date and, in any event, by no later than sixty (60) days
following each applicable Vesting Date. The issuance of the Shares represented by the Participant's vested RSUs shall be evidenced
in such a manner as the Administrator, in its discretion, deems appropriate, including, without limitation, by (i) book-entry registration
or (ii) issuance of one or more share certificates.

5. <u>Prohibitions on Transfer and Sale</u>. This Award (including any additional RSUs received by
the Participant as a result of stock dividends, stock splits, or any other similar transaction affecting the Company's securities
without receipt of consideration) shall not be transferable by the Participant, other than by will or by the laws of descent and distribution. 
Except as provided in the previous sentence, the Shares to be issued pursuant to this Agreement shall be issued, during the Participant's
lifetime, only to the Participant (or, in the event of legal incapacity or incompetence, to the Participant's guardian or representative).
This Award shall not be assigned, pledged, or hypothecated in any way (whether by operation of law or otherwise) and shall not be subject
to execution, attachment, or similar process. Any attempted transfer, assignment, pledge, hypothecation, or other disposition of
this Award or of any rights granted hereunder contrary to the provisions of this <u>Section 5</u>, or the levy of any attachment
or similar process upon this Award, shall be null and void.

6. <u>Adjustments</u>. The Plan contains provisions covering the treatment of RSUs and Shares in a
number of contingencies, such as stock splits and Corporate Transactions. Provisions in the Plan for adjustment with respect to this Award
and the related provisions with respect to successors to the business of the Company are hereby made applicable hereunder and are incorporated
herein by reference.

7. <u>Securities Law Compliance</u>. The Participant specifically acknowledges and agrees that any
sales of Shares shall be made in accordance with the requirements of the Securities Act. The Company currently has an effective
registration statement on file with the United States Securities and Exchange Commission with respect to the Shares to be granted hereunder. 
Despite registration, applicable securities laws may restrict the ability of the Participant to sell his or her Shares, including due
to the Participant's affiliation with the Company.

The Company shall not be obligated to either issue the Shares or permit the resale of any Shares if such issuance or resale would violate any applicable securities law, rule, or regulation.

8. <u>Rights as a Stockholder</u>. The Participant shall have no rights as a stockholder, including
voting and dividend rights, with respect to the RSUs subject to this Agreement, unless and until Shares represented by the Participant's
vested RSUs have been issued to the Participant and either a certificate evidencing the Shares has been issued or an appropriate entry
has been made on the Company's books. No adjustments to Shares represented by the Participant's vested RSUs shall be made
for dividends, distributions, or other rights on or with respect to the Common Stock generally if the applicable record date for any such
dividend, distribution, or right occurs before the Participant's certificate is issued or an appropriate book entry is made, except
as otherwise described in the Plan.

9. <u>Incorporation of the Plan; Clawback</u>. The Participant specifically understands and agrees
that the RSUs and the Shares to be issued under the Agreement will be issued to the Participant pursuant to the Plan, a copy of which
Plan the Participant acknowledges he or she has received, has read, and understands and by which Plan he or she agrees to be bound. 
The provisions of the Plan are incorporated herein by reference. In addition, the RSUs (and any compensation paid or Shares issued
pursuant to this Agreement) are subject to recoupment in accordance with The Sarbanes-Oxley Act, The Dodd-Frank Wall Street Reform and
Consumer Protection Act and any implementing regulations thereunder, any clawback policy adopted by the Company, including the Company's
Incentive Compensation Recovery Policy, as may be amended from time to time (the "Clawback Policy"), and any other compensation
recovery policy adopted by the Company otherwise required by applicable law. The Participant acknowledges that the Participant has reviewed,
and is bound by the terms of, the Clawback Policy. No recovery of compensation under such a clawback policy or applicable law will be
an event giving rise to a right to resign for "good reason" or for a "constructive termination" (or similar terms)
under any agreement between the Participant and the Company or any Affiliate.

10. <u>Tax Liability of the Participant and Payment of Taxes</u>. The Participant acknowledges and agrees
that any income or other taxes due from the Participant with respect to this Award or the Shares to be issued pursuant to this Agreement
or otherwise sold shall be the Participant's responsibility. In the event that the Company or an Affiliate determines that any federal,
state, local, or foreign tax or withholding payment is required relating to the RSUs, or the delivery of Shares with respect to this Award,
the Company or any Affiliate will have the right, and Participant agrees, that the Company shall cause Participant to, and Participant
shall, enter into a "same day sale" commitment with a broker-dealer that is a member of the Financial Industry Regulatory
Authority (a "**FINRA Dealer** "), whereby the Participant irrevocably elects to sell a portion of the Shares to be delivered
in connection with the RSUs to satisfy withholding obligations and whereby the FINRA Dealer irrevocably commits to forward the proceeds
necessary to satisfy the withholding obligations directly to the Company or any Affiliate (such process, "**Sell to Cover** ");
provided, however, the Administrator shall have the discretion to override Sell to Cover, (i) in lieu of selling a fractional vested
Share or (ii) in connection with withholding obligations arising outside the ordinary course, such as outside annual Vesting Dates
of the RSUs, and in each case such withholding may be through deduction from payments of any kind otherwise due to the Participant.

**The Participant hereby agrees and acknowledges that, in the event that the Company or an Affiliate determines that any federal, state, local, or foreign tax or withholding payment is required relating to the RSUs, or the delivery of Shares with respect to this Award, the Company or any Affiliate will utilize Sell to Cover, and that, in the event Sell to Cover is unavailable for any reason, the Company or any Affiliate shall be entitled to use whatever method it may deem appropriate to recover such taxes (including, without limitation, through deduction from payments of any kind otherwise due to the Participant).**

The Participant further agrees that the Administrator may, as it reasonably considers necessary, amend or vary this Agreement due to changes in tax laws to facilitate such recovery of taxes.

11. <u>Participant Acknowledgements and Authorizations</u>. The Participant hereby acknowledges the following:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a. Neither the Company nor any Affiliate is, by the Plan or this Award, obligated to continue the Participant
as an employee, director, or consultant of the Company or an Affiliate. Unless otherwise specified in a written employment or other written
compensatory agreement between the Participant and the Company or an Affiliate, the Company or any Affiliate, as applicable, reserves
the right to terminate the Participant's employment or other service relationship with the Company or an Affiliate at any time and
for any reason.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b. The Plan is discretionary in nature and may be suspended or terminated by the Company at any time.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;c. The grant of this Award is considered a one-time benefit and does not create a contractual or other right
to receive any other award under the Plan, benefits in lieu of awards, or any other benefits in the future.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;d. The Plan is a voluntary program of the Company and future awards, if any, will be at the sole discretion
of the Company, including, but not limited to, the timing of any grant, the amount of any award, vesting provisions, and the purchase
price, if any.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;e. The value of this Award is an extraordinary item of compensation outside of the scope of the Participant's
employment or consulting contract, agreement, or arrangement. As such, the Award is not part of normal or expected compensation
for purposes of calculating any severance, resignation, redundancy, end of service payments, bonuses, long-service awards, pension or
retirement benefits, or similar payments. The future value of the shares of Common Stock is unknown and cannot be predicted with
certainty.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;f. The Participant (i) authorizes the Company and each Affiliate and any agent of the Company or any
Affiliate administering the Plan or providing Plan recordkeeping services to disclose to the Company or any of its Affiliates such information
and data as the Company or any such Affiliate shall request in order to facilitate the grant of the Award and the administration of the
Plan; and (ii) authorizes the Company and each Affiliate to store and transmit such information in electronic form for the
purposes set forth in this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;g. The obligation of the Company to deliver Shares pursuant to this Award constitutes an unfunded and unsecured
obligation of the Company. Until Shares are delivered, the Participant shall have no rights under this Agreement or the Plan, other than
those of a general unsecured creditor of the Company. No assets of the Company shall be set aside for the settlement of the RSUs.

12. <u>Notices</u>. By accepting the Award, the Participant agrees that notices may be given to the Participant
in writing either at the Participant's home or mailing address as shown in the records of the Company or an Affiliate or by electronic
transmission (including e-mail or reference to a website or other URL) sent to the Participant through the normal process employed by
the Company or the Affiliate, as applicable, for communicating electronically with its employees or other service providers.

13. <u>Assignment and Successors</u>.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a. This Agreement is personal to the Participant and, without the prior written approval of the Administrator,
shall not be assignable by the Participant, other than by will or the laws of descent and distribution. This Agreement shall inure
to the benefit of and be enforceable by the Participant's legal representatives and beneficiaries.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b. This Agreement shall inure to the benefit of and be binding upon the Company and its successors and assigns.

14. <u>Governing Law</u>. This Agreement shall be construed and enforced in accordance with the laws
of the State of Delaware, without giving effect to the conflict of law principles thereof. For the purpose of litigating any dispute
that arises under this Agreement, whether at law or in equity, the parties hereby consent to exclusive jurisdiction in the Commonwealth
of Pennsylvania and agree that such litigation shall be conducted in the state courts of the Commonwealth of Pennsylvania or the federal
courts of the United States for the Eastern District of Pennsylvania.

15. <u>Severability</u>. If any provision of this Agreement is held to be invalid or unenforceable by
a court of competent jurisdiction, then such provision or provisions shall be modified to the extent necessary to make such provision
valid and enforceable, and to the extent that this is impossible, then such provision shall be deemed to be excised from this Agreement,
and the validity, legality, and enforceability of the rest of this Agreement shall not be affected thereby.

16. <u>Entire Agreement</u>. This Agreement, together with the Grant Notice and the Plan, constitutes
the entire agreement and understanding between the parties hereto with respect to the subject matter hereof and supersedes all prior oral
or written agreements and understandings relating to the subject matter hereof, including without limitation any offer letter provision
related to the subject matter hereof. No statement, representation, warranty, covenant, or agreement not expressly set forth in
this Agreement shall affect or be used to interpret, change, or restrict the express terms and provisions of this Agreement; provided,
however, in any event, this Agreement shall be subject to and governed by the Plan.

17. <u>Modifications and Amendments; Waivers and Consents</u>. The terms and provisions of this Agreement
may be modified or amended as provided in the Plan. Except as provided in the Plan, the terms and provisions of this Agreement may
be waived, or consent for the departure therefrom granted, only by written document executed by the party entitled to the benefits of
such terms or provisions. No such waiver or consent shall be deemed to be or shall constitute a waiver or consent with respect to
any other terms or provisions of this Agreement, whether or not similar. Each such waiver or consent shall be effective only in the specific
instance and for the purpose for which it was given, and shall not constitute a continuing waiver or consent.

18. <u>Code Section 409A</u>. The Award of RSUs evidenced by this Agreement is intended to be exempt
from the nonqualified deferred compensation rules of Code Section 409A as a "short-term deferral" within the meaning
of Code Section 409A and, to the maximum extent permitted, shall be construed accordingly. Notwithstanding anything to the contrary
in the Plan or this Agreement, none of the Company, its Affiliates, the Board of Directors, the Administrator, or any of their respective
agents or delegates will have any obligation to take any action to prevent the assessment of any excise tax or penalty on the Participant
under Code Section 409A, and none of the Company, its Affiliates, the Board of Directors, the Administrator, or any of their respective
agents or delegates will have any liability to the Participant or any other person for such tax or penalty.

To the extent that the RSUs constitute "deferred compensation" under Code Section 409A, a termination of service occurs only upon an event that would be a "separation from service" within the meaning of Code Section 409A. If, at the time of the Participant's "separation from service," (i) the Participant is a "specified employee" within the meaning of Code Section 409A (and as applied according to procedures of the Company and its Affiliates), and (ii) the Administrator makes a good faith determination that an amount payable under this Agreement on account of the Participant's separation from service constitutes non-qualified deferred compensation (within the meaning of Code Section 409A), the payment of which is required to be delayed pursuant to the six (6)-month delay rule set forth in Code Section 409A to avoid taxes or penalties under Code Section 409A (the "**Delay Period**"), then the Company will not pay such amount on the otherwise scheduled payment date but will instead pay it in a lump sum on the first business day after the Delay Period (or upon the Participant's death, if earlier), without interest. Each installment of RSUs that vest under this Agreement (if there is more than one installment) will be considered one of a series of separate payments for purposes of Code Section 409A.

19. <u>Data Privacy</u>. By entering into this Agreement, the Participant: (i) authorizes the Company
and each Affiliate, and any agent of the Company or any Affiliate administering the Plan or providing Plan recordkeeping services, to
disclose to the Company or any of its Affiliates such information and data as the Company or any such Affiliate shall request in order
to facilitate the grant of restricted stock units and the administration of the Plan; and (ii) authorizes the Company and each Affiliate
to store and transmit such information in electronic form for the purposes set forth in this Agreement.

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## Exhibit 99.4

**Exhibit 99.4**

Section 16 Officer Form

**MADRIGAL PHARMACEUTICALS, INC.<br> 2025 INDUCEMENT STOCK PLAN**

**RESTRICTED Stock Unit Award<br> Grant Notice**

1. **Name of Participant:** 

2. **Grant Date of the RSUs <br> (the "Grant Date"):** 

3. **Number of RSUs:** 

4. **Vesting of Award:** Subject to the Participant's continuous employment or other service relationship with or to the Company or any of its Affiliates as an employee, director, and/or consultant from the Grant Date through each of the following applicable dates (each such date, a "**Vesting Date** "), the RSUs shall vest twenty-five percent (25%) of the Number of RSUs above on each of the first, second, third, and fourth anniversaries of the Grant Date. Any terms used and not defined herein have the meanings ascribed to such terms in the Madrigal Pharmaceuticals, Inc. 2025 Inducement Stock Plan (as it has been and may be amended and/or restated from time to time, the "**Plan** ").

**By signing this Grant Notice or by electronic acknowledgment of this Grant Notice, the Participant acknowledges receipt of and agrees to all the terms and conditions described in this Restricted Stock Unit Award Grant Notice, the attached Restricted Stock Unit Agreement, and the Plan. The Participant acknowledges that the Participant has carefully reviewed the Plan and agrees that the Plan will control in the event any provision of the Agreement is inconsistent with the Plan.**

---

| |
|:---|
| **MADRIGAL PHARMACEUTICALS, INC.** |
| By: |
| Name: |
| Title: |
| **PARTICIPANT** |
| <br> **ATTACHMENT**: Restricted Stock Unit Agreement |

---

**MADRIGAL PHARMACEUTICALS, INC.<br> 2025 INDUCEMENT STOCK PLAN**

**RESTRICTED STOCK UNIT AGREEMENT**

This RESTRICTED STOCK UNIT AGREEMENT (the "**Agreement**") is made as of the "Grant Date" set forth in the Restricted Stock Unit Award Grant Notice ("**Grant Notice**") between MADRIGAL PHARMACEUTICALS, INC. (the "**Company**"), a Delaware corporation, and the individual whose name appears on the Grant Notice (the "**Participant**").

WHEREAS, the Company has adopted the Madrigal Pharmaceuticals, Inc. 2025 Inducement Stock Plan (as it has been and may be amended and/or restated from time to time, the "**Plan**") to promote the interests of the Company by providing an incentive for prospective officers and employees who are not currently employed by the Company and its Affiliates to accept employment with the Company or an Affiliate;

WHEREAS, pursuant to the provisions of the Plan, the Company desires to grant to the Participant restricted stock units ("**RSUs**") related to the Company's common stock, $0.0001 par value per share ("**Common Stock**"), in accordance with the provisions of the Plan, all on the terms and conditions hereinafter set forth;

WHEREAS, the RSUs have been granted as an inducement pursuant to Rule 5635(c)(4) of the Marketplace Rules of NASDAQ Stock Market, Inc.; and

WHEREAS, the Company and the Participant understand and agree that any terms used and not defined herein have the meanings ascribed to such terms in the Plan.

NOW, THEREFORE, in consideration of the promises and the mutual covenants contained herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto hereby agree as follows:

1. <u>Grant of Award</u>. The Company hereby grants to the Participant a Stock-Based Award for the
number of RSUs set forth in the Grant Notice (the "**Award** "). Each RSU represents a contingent entitlement of the
Participant to receive one share of Common Stock, on the terms and conditions and subject to all the limitations set forth herein, in
the Grant Notice, and in the Plan, which are incorporated herein by reference.

2. <u>Vesting of Award</u>.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a. Subject to the terms and conditions set forth in this Agreement and the Plan: (i) the Award shall
vest as set forth in the Grant Notice and is subject to the other terms and conditions of this Agreement and the Plan; and (ii) upon
vesting, the Participant shall be entitled to receive such number of shares of Common Stock equivalent to the number of such vested RSUs.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b. Notwithstanding anything to the contrary in the Grant Notice or this Agreement, any fractional Shares
resulting from the vesting schedule set forth in the Grant Notice will be rounded to the nearest whole Share and shall be rounded up or
down as necessary as of the last Vesting Date; provided, in all cases, the Participant cannot vest in more than the number of RSUs set
forth in the Grant Notice.

3. <u>Forfeiture of Unvested RSUs</u>.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a. Except as otherwise set forth in this Agreement, or a separate written agreement between Participant and
the Company, if the Participant ceases the Participant's continuous employment or other service relationship with or to the Company
or any of its Affiliates ()"**Termination**") for any reason, then all then-unvested RSUs shall automatically and immediately
be forfeited to the Company as of such Termination, and this Agreement and the Grant Notice shall automatically and immediately terminate
and be of no further force or effect.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b. For purposes of this Agreement, the Participant's continuous employment or other service relationship
with or to the Company or any of its Affiliates does not terminate when the Participant goes on a bona fide leave of absence that was
approved by the Administrator in writing, if the terms of the leave provide for continued service crediting, or when continued service
crediting is required by applicable law. The Participant's continuous employment or other service relationship with or to the Company
or any of its Affiliates terminates in any event when the approved leave ends unless the Participant immediately returns to active work.
The Administrator may determine, in its discretion, which leaves count for this purpose and when the Participant's continuous employment
or other service relationship with or to the Company or any of its Affiliates terminates for all purposes under the Plan in accordance
with the provisions of the Plan.

4. <u>Delivery of Award; Evidence of Issuance</u>. Delivery of the Shares represented by the Participant's
vested RSUs shall be made as soon as practicable after the applicable Vesting Date and, in any event, by no later than sixty (60) days
following each applicable Vesting Date. The issuance of the Shares represented by the Participant's vested RSUs shall be evidenced
in such a manner as the Administrator, in its discretion, deems appropriate, including, without limitation, by (i) book-entry registration
or (ii) issuance of one or more share certificates.

5. <u>Prohibitions on Transfer and Sale</u>. This Award (including any additional RSUs received by
the Participant as a result of stock dividends, stock splits, or any other similar transaction affecting the Company's securities
without receipt of consideration) shall not be transferable by the Participant, other than by will or by the laws of descent and distribution. 
Except as provided in the previous sentence, the Shares to be issued pursuant to this Agreement shall be issued, during the Participant's
lifetime, only to the Participant (or, in the event of legal incapacity or incompetence, to the Participant's guardian or representative).
This Award shall not be assigned, pledged, or hypothecated in any way (whether by operation of law or otherwise) and shall not be subject
to execution, attachment, or similar process. Any attempted transfer, assignment, pledge, hypothecation, or other disposition of
this Award or of any rights granted hereunder contrary to the provisions of this <u>Section 5</u>, or the levy of any attachment
or similar process upon this Award, shall be null and void.

6. <u>Adjustments</u>. The Plan contains provisions covering the treatment of RSUs and Shares in a
number of contingencies, such as stock splits and Corporate Transactions. Provisions in the Plan for adjustment with respect to this Award
and the related provisions with respect to successors to the business of the Company are hereby made applicable hereunder and are incorporated
herein by reference.

7. <u>Securities Law Compliance</u>. The Participant specifically acknowledges and agrees that any
sales of Shares shall be made in accordance with the requirements of the Securities Act. The Company currently has an effective
registration statement on file with the United States Securities and Exchange Commission with respect to the Shares to be granted hereunder. 
Despite registration, applicable securities laws may restrict the ability of the Participant to sell his or her Shares, including due
to the Participant's affiliation with the Company.

The Company shall not be obligated to either issue the Shares or permit the resale of any Shares if such issuance or resale would violate any applicable securities law, rule, or regulation.

8. <u>Rights as a Stockholder</u>. The Participant shall have no rights as a stockholder, including
voting and dividend rights, with respect to the RSUs subject to this Agreement, unless and until Shares represented by the Participant's
vested RSUs have been issued to the Participant and either a certificate evidencing the Shares has been issued or an appropriate entry
has been made on the Company's books. No adjustments to Shares represented by the Participant's vested RSUs shall be made
for dividends, distributions, or other rights on or with respect to the Common Stock generally if the applicable record date for any such
dividend, distribution, or right occurs before the Participant's certificate is issued or an appropriate book entry is made, except
as otherwise described in the Plan.

9. <u>Incorporation of the Plan; Clawback</u>. The Participant specifically understands and agrees
that the RSUs and the Shares to be issued under the Agreement will be issued to the Participant pursuant to the Plan, a copy of which
Plan the Participant acknowledges he or she has received, has read, and understands and by which Plan he or she agrees to be bound. 
The provisions of the Plan are incorporated herein by reference. In addition, the RSUs (and any compensation paid or Shares issued
pursuant to this Agreement) are subject to recoupment in accordance with The Sarbanes-Oxley Act, The Dodd-Frank Wall Street Reform and
Consumer Protection Act and any implementing regulations thereunder, any clawback policy adopted by the Company, including the Company's
Incentive Compensation Recovery Policy, as may be amended from time to time (the "Clawback Policy"), and any other compensation
recovery policy adopted by the Company otherwise required by applicable law. The Participant acknowledges that the Participant has reviewed,
and is bound by the terms of, the Clawback Policy. No recovery of compensation under such a clawback policy or applicable law will be
an event giving rise to a right to resign for "good reason" or for a "constructive termination" (or similar terms)
under any agreement between the Participant and the Company or any Affiliate.

10. <u>Tax Liability of the Participant and Payment of Taxes</u>. The Participant acknowledges and agrees
that any income or other taxes due from the Participant with respect to this Award or the Shares to be issued pursuant to this Agreement
or otherwise sold shall be the Participant's responsibility. In the event that the Company or an Affiliate determines that any federal,
state, local, or foreign tax or withholding payment is required relating to the RSUs, or the delivery of Shares with respect to this Award,
the Company or any Affiliate, subject to the proviso below, will have the right to withhold the delivery of vested Shares otherwise deliverable
under this Agreement to meet such obligations, provided that, to the extent required to avoid adverse accounting consequences to the Company,
the Shares so withheld will have an aggregate Fair Market Value not exceeding the minimum amount of tax required to be withheld by applicable
laws and fractional Shares will not be retained to satisfy any portion of the Company's withholding obligation (such process, "**Net Settlement** "); provided, however, the Administrator shall have the discretion to override Net Settlement, (i) provided ninety
(90) days' advance notice is given prior to a Vesting Date from the Company to the Participant, in which case such withholding shall
be through a "same day sale" commitment with a broker-dealer that is a member of the Financial Industry Regulatory Authority
(a "**FINRA Dealer** "), whereby the Participant irrevocably elects to sell a portion of the Shares to be delivered in connection
with the RSUs to satisfy withholding obligations and whereby the FINRA Dealer irrevocably commits to forward the proceeds necessary to
satisfy the withholding obligations directly to the Company or any Affiliate (such process, "**Sell to Cover**") or (ii)(A) in
lieu of withholding (under Net Settlement) selling (under Sell to Cover) a fractional vested Share or (B) in connection with withholding
obligations arising outside the ordinary course, such as outside annual Vesting Dates of the RSUs, in which case such withholding may
be through deduction from payments of any kind otherwise due to the Participant.

**The Participant hereby (i) agrees that the Company or any Affiliate shall be entitled to use the foregoing methods to recover such taxes and (ii) acknowledges that, absent further action by the Administrator, in the event that the Company or an Affiliate determines that any federal, state, local, or foreign tax or withholding payment is required relating to the RSUs, or the delivery of Shares with respect to this Award, the Company or any Affiliate will utilize Net Settlement.**

The Participant further agrees that the Administrator may, as it reasonably considers necessary, amend or vary this Agreement due to changes in tax laws to facilitate such recovery of taxes.

11. <u>Participant Acknowledgements and Authorizations</u>. The Participant hereby acknowledges the following:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a. Neither the Company nor any Affiliate is, by the Plan or this Award, obligated to continue the Participant
as an employee, director, or consultant of the Company or an Affiliate. Unless otherwise specified in a written employment or other written
compensatory agreement between the Participant and the Company or an Affiliate, the Company or any Affiliate, as applicable, reserves
the right to terminate the Participant's employment or other service relationship with the Company or an Affiliate at any time and
for any reason.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b. The Plan is discretionary in nature and may be suspended or terminated by the Company at any time.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;c. The grant of this Award is considered a one-time benefit and does not create a contractual or other right
to receive any other award under the Plan, benefits in lieu of awards, or any other benefits in the future.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;d. The Plan is a voluntary program of the Company and future awards, if any, will be at the sole discretion
of the Company, including, but not limited to, the timing of any grant, the amount of any award, vesting provisions, and the purchase
price, if any.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;e. The value of this Award is an extraordinary item of compensation outside of the scope of the Participant's
employment or consulting contract, agreement, or arrangement. As such, the Award is not part of normal or expected compensation
for purposes of calculating any severance, resignation, redundancy, end of service payments, bonuses, long-service awards, pension or
retirement benefits, or similar payments. The future value of the shares of Common Stock is unknown and cannot be predicted with
certainty.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;f. The Participant (i) authorizes the Company and each Affiliate and any agent of the Company or any
Affiliate administering the Plan or providing Plan recordkeeping services to disclose to the Company or any of its Affiliates such information
and data as the Company or any such Affiliate shall request in order to facilitate the grant of the Award and the administration of the
Plan; and (ii) authorizes the Company and each Affiliate to store and transmit such information in electronic form for the
purposes set forth in this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;g. The obligation of the Company to deliver Shares pursuant to this Award constitutes an unfunded and unsecured
obligation of the Company. Until Shares are delivered, the Participant shall have no rights under this Agreement or the Plan, other than
those of a general unsecured creditor of the Company. No assets of the Company shall be set aside for the settlement of the RSUs.

12. <u>Notices</u>. By accepting the Award, the Participant agrees that notices may be given to the Participant
in writing either at the Participant's home or mailing address as shown in the records of the Company or an Affiliate or by electronic
transmission (including e-mail or reference to a website or other URL) sent to the Participant through the normal process employed by
the Company or the Affiliate, as applicable, for communicating electronically with its employees or other service providers.

13. <u>Assignment and Successors</u>.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a. This Agreement is personal to the Participant and, without the prior written approval of the Administrator,
shall not be assignable by the Participant, other than by will or the laws of descent and distribution. This Agreement shall inure
to the benefit of and be enforceable by the Participant's legal representatives and beneficiaries.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b. This Agreement shall inure to the benefit of and be binding upon the Company and its successors and assigns.

14. <u>Governing Law</u>. This Agreement shall be construed and enforced in accordance with the laws
of the State of Delaware, without giving effect to the conflict of law principles thereof. For the purpose of litigating any dispute
that arises under this Agreement, whether at law or in equity, the parties hereby consent to exclusive jurisdiction in the Commonwealth
of Pennsylvania and agree that such litigation shall be conducted in the state courts of the Commonwealth of Pennsylvania or the federal
courts of the United States for the Eastern District of Pennsylvania.

15. <u>Severability</u>. If any provision of this Agreement is held to be invalid or unenforceable by
a court of competent jurisdiction, then such provision or provisions shall be modified to the extent necessary to make such provision
valid and enforceable, and to the extent that this is impossible, then such provision shall be deemed to be excised from this Agreement,
and the validity, legality, and enforceability of the rest of this Agreement shall not be affected thereby.

16. <u>Entire Agreement</u>. This Agreement, together with the Grant Notice and the Plan, constitutes
the entire agreement and understanding between the parties hereto with respect to the subject matter hereof and supersedes all prior oral
or written agreements and understandings relating to the subject matter hereof, including without limitation any offer letter provision
related to the subject matter hereof. No statement, representation, warranty, covenant, or agreement not expressly set forth in
this Agreement shall affect or be used to interpret, change, or restrict the express terms and provisions of this Agreement; provided,
however, in any event, this Agreement shall be subject to and governed by the Plan.

17. <u>Modifications and Amendments; Waivers and Consents</u>. The terms and provisions of this Agreement
may be modified or amended as provided in the Plan. Except as provided in the Plan, the terms and provisions of this Agreement may
be waived, or consent for the departure therefrom granted, only by written document executed by the party entitled to the benefits of
such terms or provisions. No such waiver or consent shall be deemed to be or shall constitute a waiver or consent with respect to
any other terms or provisions of this Agreement, whether or not similar. Each such waiver or consent shall be effective only in the specific
instance and for the purpose for which it was given, and shall not constitute a continuing waiver or consent.

18. <u>Code Section 409A</u>. The Award of RSUs evidenced by this Agreement is intended to be exempt
from the nonqualified deferred compensation rules of Code Section 409A as a "short-term deferral" within the meaning
of Code Section 409A and, to the maximum extent permitted, shall be construed accordingly. Notwithstanding anything to the contrary
in the Plan or this Agreement, none of the Company, its Affiliates, the Board of Directors, the Administrator, or any of their respective
agents or delegates will have any obligation to take any action to prevent the assessment of any excise tax or penalty on the Participant
under Code Section 409A, and none of the Company, its Affiliates, the Board of Directors, the Administrator, or any of their respective
agents or delegates will have any liability to the Participant or any other person for such tax or penalty.

To the extent that the RSUs constitute "deferred compensation" under Code Section 409A, a termination of service occurs only upon an event that would be a "separation from service" within the meaning of Code Section 409A. If, at the time of the Participant's "separation from service," (i) the Participant is a "specified employee" within the meaning of Code Section 409A (and as applied according to procedures of the Company and its Affiliates), and (ii) the Administrator makes a good faith determination that an amount payable under this Agreement on account of the Participant's separation from service constitutes non-qualified deferred compensation (within the meaning of Code Section 409A), the payment of which is required to be delayed pursuant to the six (6)-month delay rule set forth in Code Section 409A to avoid taxes or penalties under Code Section 409A (the "**Delay Period**"), then the Company will not pay such amount on the otherwise scheduled payment date but will instead pay it in a lump sum on the first business day after the Delay Period (or upon the Participant's death, if earlier), without interest. Each installment of RSUs that vest under this Agreement (if there is more than one installment) will be considered one of a series of separate payments for purposes of Code Section 409A.

19. <u>Data Privacy</u>. By entering into this Agreement, the Participant: (i) authorizes the Company
and each Affiliate, and any agent of the Company or any Affiliate administering the Plan or providing Plan recordkeeping services, to
disclose to the Company or any of its Affiliates such information and data as the Company or any such Affiliate shall request in order
to facilitate the grant of restricted stock units and the administration of the Plan; and (ii) authorizes the Company and each Affiliate
to store and transmit such information in electronic form for the purposes set forth in this Agreement.

[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

## Exhibit 99.5

**Exhibit 99.5**

**MADRIGAL PHARMACEUTICALS, INC.<br> 2025 INDUCEMENT STOCK PLAN**

**FORM OF market Stock Unit Award<br> Grant Notice**

1. **Name of Participant:** [●]

2. **Grant Date of the MSUs (the "Grant Date"):** [●]

3. **Target Number of MSUs:** [●]

4. **Maximum Number of MSUs:** [●]

5. **Performance Period:** The period commencing on [______] and ending on [_________] (subject to Section 5 of the Market Stock Unit Agreement (the "**Performance Period** ")).

6. **Performance Conditions:** The number of MSUs the Participant may earn and that may vest in accordance with the Vesting Schedule will depend upon the Relative TSR (as defined in the Market Stock Unit Agreement) and will be determined in accordance with Section 2 of the Market Stock Unit Agreement.

7. **Vesting Schedule:** Subject to Sections 4 and 5 of the Market Stock Unit Agreement and the terms of the Plan, the Eligible MSUs (as defined in the Market Stock Unit Agreement) vest on the date the Relative TSR is determined by the Administrator following the end of the Performance Period (the "**Vesting Date** "), subject to the Participant's continued Service (as defined in the Market Stock Unit Agreement) through the Vesting Date.

Any terms used and not defined herein have the meanings ascribed to such terms in the Madrigal Pharmaceuticals, Inc. 2025 Inducement Stock Plan (as it has been and may be amended and/or restated from time to time, the "**Plan**") or in the Market Stock Unit Agreement.

**By signing this Grant Notice or by electronic acknowledgment of this Grant Notice, the Participant acknowledges receipt of and agrees to all the terms and conditions described in this Market Stock Unit Award Grant Notice, the attached Market Stock Unit Agreement, and the Plan. The Participant acknowledges that the Participant has carefully reviewed the Plan and agrees that the Plan will control in the event any provision of the Agreement is inconsistent with the Plan**.

---

| |
|:---|
| **MADRIGAL PHARMACEUTICALS, INC.** |
| By: |
| Name: |
| Title: |
| **PARTICIPANT** |

---

**ATTACHMENT**: Market Stock Unit Agreement

**MADRIGAL PHARMACEUTICALS, INC.<br> 2025 INDUCEMENT STOCK PLAN**

**MARKET STOCK UNIT AGREEMENT**

This MARKET STOCK UNIT AGREEMENT (the "**Agreement**") is made as of the "Grant Date" set forth in the Market Stock Unit Award Grant Notice ("**Grant Notice**") between MADRIGAL PHARMACEUTICALS, INC. (the "**Company**"), a Delaware corporation, and the individual whose name appears on the Grant Notice (the "**Participant**").

WHEREAS, the Company has adopted the Madrigal Pharmaceuticals, Inc. 2025 Inducement Stock Plan (as it has been and may be amended and/or restated from time to time, the "**Plan**") to promote the interests of the Company by providing an incentive for prospective officers and employees who are not currently employed by the Company and its Affiliates to accept employment with the Company or an Affiliate;

WHEREAS, pursuant to the provisions of the Plan, the Company desires to grant to the Participant market stock units ("**MSUs**") related to the Company's common stock, $0.0001 par value per share ("**Common Stock**"), in accordance with the provisions of the Plan, all on the terms and conditions hereinafter set forth;

WHEREAS, the MSUs have been granted as an inducement pursuant to Rule 5635(c)(4) of the Marketplace Rules of NASDAQ Stock Market, Inc.; and

WHEREAS, the Company and the Participant understand and agree that any terms used and not defined herein have the meanings ascribed to such terms in the Plan.

NOW, THEREFORE, in consideration of the promises and the mutual covenants contained herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto hereby agree as follows:

1. <u>Grant of Award</u>. The Company hereby grants to the Participant a Stock-Based Award for the
target number of MSUs set forth in the Grant Notice (the "**Award** "). Each MSU represents a contingent entitlement
of the Participant to receive one share of Common Stock, on the terms and conditions and subject to all the limitations set forth herein,
in the Grant Notice, and in the Plan, which are incorporated herein by reference.

2. <u>Performance Conditions</u>.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) <u>General</u>. The number of MSUs earned by the Participant ()"**Eligible MSUs**") will
depend upon the total stockholder return ()"**TSR**") of the Company during the Performance Period (the "**Company TSR**") relative to the TSRs of the Indexed Companies during the Performance Period (each, an "**Indexed Company TSR** ").
The "**Index**" means the Nasdaq Biotechnology Index or any successor index thereto. "**Indexed Companies** "
means the companies (other than the Company) that are in the Index as of the beginning of the Performance Period and whose securities
are actively traded on a nationally recognized stock exchange as of the end of the Performance Period (regardless of whether such companies
remain in the Index at the end of the Performance Period). The actual number of MSUs that are earned and vest on the Vesting Date shall
be determined as follows:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) <u>Relative TSR Calculation</u>. Except as provided under Section 5 below, the "**Relative TSR**" will be determined as follows:

<u>Step 1</u>: Calculate the beginning price with respect to the Company and each Indexed Company by determining the average of the closing market prices of such company's common stock on the principal exchange on which such stock is traded for the last thirty (30) market trading days prior to the commencement of the Performance Period (each, a "**Beginning Price**"). For this purpose, the value of dividends and other distributions (the ex-dividend date for which occurs during the thirty (30)-market-trading-day measurement period) shall be added to, and included in, the Beginning Price, determined by treating them as reinvested in additional shares of stock at the closing market price on the ex-dividend date. The Beginning Price shall be adjusted appropriately to reflect any changes in the capitalization of the Company or an Indexed Company, as the case may be, during such thirty (30) market trading day measurement period.

<u>Step 2</u>: Calculate the ending price with respect to the Company and each Indexed Company by determining the average of the closing market prices of such company's common stock on the principal exchange on which such stock is traded for the thirty (30) consecutive market trading days ending on the last trading day of the Performance Period (each, an "**Ending Price**"). For this purpose, the value of dividends and other distributions (the ex-dividend date for which occurs during the Performance Period) shall be added to, and included in, the Ending Price, determined by treating them as reinvested in additional shares of stock at the closing market price on the ex-dividend date. The Ending Price shall be adjusted appropriately to reflect any changes in the capitalization of the Company or an Indexed Company, as the case may be, during the Performance Period.

<u>Step 3</u>: Calculate the Company TSR and each Indexed Company TSR by applying the following formula: (Ending Price/Beginning Price)-1. The Company TSR and each Indexed Company TSR will each be expressed as a percent of increase (i.e., a positive percent) or decrease (i.e., a negative percent) rounded to two decimal places (applying standard rounding principles).

<u>Step 4</u>: Calculate the Company TSR percentile ranking among the Indexed Company TSRs (the "**Relative TSR**") by ranking the Company TSR and the Indexed Company TSRs from highest (highest positive percentage) to lowest (highest negative percentage).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) <u>Eligible MSU Calculation</u>. Based on the Relative TSR, the number of Eligible MSUs will be the product
of (x) the Applicable Percentage (as defined below) multiplied by (y) the Target Number of MSUs, with the number of resulting
shares rounded to the nearest whole share (applying standard rounding principles).

The "**Applicable Percentage**" will be determined as follows:

---

| | |
|:---|:---|
| **Relative TSR** | **Applicable Percentage** |
| Below 25th Percentile | 0% |
| 25th Percentile | 50% |
| 50th Percentile | 100% |
| 90th Percentile | 200% |

---

If the Company TSR ranks among the Indexed Company TSRs at a percentile that falls between the percentile thresholds set forth above, the Applicable Percentage will be determined based on a linear interpolation between the corresponding Applicable Percentages for such thresholds. Notwithstanding the foregoing, the Applicable Percentage may not exceed 100% if the Company TSR is less than zero.

All determinations regarding the Beginning Price, the Ending Price, the Company TSR, the Indexed Company TSRs, the Relative TSR, and the Applicable Percentage will be made by the Administrator in its sole discretion and all such determinations will be final and binding on all parties.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) <u>Example (for illustration purposes only)</u>. If (i) the Company TSR ranks among the Indexed Company
TSRs at the 70th percentile and (ii) the Company TSR is greater than or equal to zero, then 150% of the Target Number of MSUs would
be Eligible MSUs and would be eligible to vest on the Vesting Date.

3. <u>Vesting Schedule</u>. Except as set forth in Section 5, the MSUs that become Eligible PSUs in
accordance with Section 2 of this Agreement will vest on the Vesting Date, subject to the Participant's continuous employment
or other service relationship with or to the Company or any of its Affiliates as an employee, director, and/or consultant ()"**Service** ")
through the Vesting Date.

4. <u>Termination of Service</u>. Except as otherwise set forth in this Agreement, or a separate written
agreement between the Participant and the Company entered into after the date of this Agreement, if the Participant ceases the Participant's
Service ()"**Termination**") for any reason, then all then-unvested MSUs shall automatically and immediately be forfeited
to the Company as of such Termination, and this Agreement and the Grant Notice shall automatically and immediately terminate and be of
no further force or effect. For purposes of this Agreement, the Participant's continuous Service does not terminate solely because
the Participant goes on a Company-approved leave of absence if the terms of the leave provide for continued Service crediting, or when
continued Service crediting is required by applicable law. The Participant's Service terminates in any event when the approved leave
ends unless the Participant (i) is approved by the Company to return to active work and (ii) immediately returns to active work.
The Administrator may determine, in accordance with applicable law, which leaves count for this purpose and when the Participant's
Service terminates for all purposes under the Plan in accordance with the provisions of the Plan.

5. <u>Change of Control</u>. In the event that a Change of Control occurs during the Performance Period,
the Performance Period shall be deemed to end upon the date of the Change of Control for purposes of determining the Ending Price for
the Company and each Indexed Company, the Company TSR, the Indexed Company TSRs, and the Relative TSR (such shortened Performance Period,
the "**CIC-Adjusted Performance Period** "), and any references to the "Performance Period" under Section 2(b) will
refer to the "CIC-Adjusted Performance Period." The number of MSUs that become Eligible MSUs will be determined in accordance
with Sections 2(b) and (c). The Participant shall vest in 100% of the number of Eligible MSUs determined in accordance with this
Section 5 on the last day of the originally scheduled Performance Period set forth in the Grant Notice, subject to the Participant
continued Service through such date. Following a Change of Control, the MSUs that become Eligible MSUs pursuant to this Section 5
will be subject to any vesting acceleration provisions set forth in any Severance and Change of Control Agreement between the Participant
and the Company or an Affiliate.

6. <u>Delivery of Award; Evidence of Issuance</u>. Delivery of the Shares represented by the Participant's
vested MSUs shall be made as soon as practicable after the Vesting Date and, in any event, by no later than the earlier of (i) sixty
(60) days following the Vesting Date and (ii) March 15<sup>th</sup> of the year following the year in which the Performance
Period ends. The issuance of the Shares represented by the Participant's vested MSUs shall be evidenced in such a manner as the
Administrator, in its discretion, deems appropriate, including, without limitation, by (i) book-entry registration or (ii) issuance
of one or more share certificates.

7. <u>Prohibitions on Transfer and Sale</u>. This Award (including any additional MSUs received by
the Participant as a result of stock dividends, stock splits, or any other similar transaction affecting the Company's securities
without receipt of consideration) shall not be transferable, without the prior approval of the Administrator, by the Participant, other
than by will or by the laws of descent and distribution. Except as provided in the previous sentence, the Shares to be issued pursuant
to this Agreement shall be issued, during the Participant's lifetime, only to the Participant (or, in the event of legal incapacity
or incompetence, to the Participant's guardian or representative), and this Award shall not be assigned, pledged, or hypothecated
in any way (whether by operation of law or otherwise) and shall not be subject to execution, attachment, or similar process. Any
attempted transfer, assignment, pledge, hypothecation, or other disposition of this Award or of any rights granted hereunder contrary
to the provisions of this Section 7, or the levy of any attachment or similar process upon this Award, shall be null and void.

8. <u>Adjustments</u>. The Plan contains provisions covering the treatment of MSUs and Shares in a
number of contingencies, such as stock splits and Corporate Transactions. Provisions in the Plan for adjustment with respect to this Award
and the related provisions with respect to successors to the business of the Company are hereby made applicable hereunder and are incorporated
herein by reference.

9. <u>Securities Law Compliance</u>. The Participant specifically acknowledges and agrees that any
sales of Shares shall be made in accordance with the requirements of the Securities Act. The Company currently has an effective
registration statement on file with the United States Securities and Exchange Commission with respect to the Shares to be granted hereunder. 
Despite registration, applicable securities laws may restrict the ability of the Participant to sell his or her Shares, including due
to the Participant's affiliation with the Company. The Company shall not be obligated to either issue the Shares or permit
the resale of any Shares if such issuance or resale would violate any applicable securities law, rule, or regulation.

10. <u>Rights as a Stockholder</u>. The Participant shall have no rights as a stockholder, including
voting and dividend rights, with respect to the MSUs subject to this Agreement, unless and until Shares represented by the Participant's
vested MSUs have been issued to the Participant and either a certificate evidencing the Shares has been issued or an appropriate entry
has been made on the Company's books. No adjustments to Shares represented by the Participant's vested MSUs shall be made
for dividends, distributions, or other rights on or with respect to the Common Stock generally if the applicable record date for any such
dividend, distribution, or right occurs before the Participant's certificate is issued or an appropriate book entry is made, except
as otherwise described in the Plan.

11. <u>Incorporation of the Plan; Clawback</u>. The Participant specifically understands and agrees that the
MSUs and the Shares to be issued under the Agreement will be issued to the Participant pursuant to the Plan, a copy of which Plan the
Participant acknowledges he or she has received, has read, and understands and by which Plan he or she agrees to be bound. The provisions
of the Plan are incorporated herein by reference. In addition, the MSUs (and any compensation paid or Shares issued pursuant to
this Agreement) are subject to recoupment in accordance with The Sarbanes-Oxley Act, The Dodd-Frank Wall Street Reform and Consumer Protection
Act and any implementing regulations thereunder, any clawback policy adopted by the Company, including the Company's Incentive Compensation
Recovery Policy, as may be amended from time to time (the "Clawback Policy"), and any other compensation recovery policy adopted
by the Company otherwise required by applicable law. The Participant acknowledges that the Participant has reviewed, and is bound by the
terms of, the Clawback Policy. No recovery of compensation under such a clawback policy or applicable law will be an event giving rise
to a right to resign for "good reason" or for a "constructive termination" (or similar terms) under any agreement
between the Participant and the Company or any Affiliate.

12. <u>Tax Liability of the Participant and Payment of Taxes</u>. The Participant acknowledges and agrees
that any income or other taxes due from the Participant with respect to this Award or the Shares to be issued pursuant to this Agreement
or otherwise sold shall be the Participant's responsibility. In the event that the Company or an Affiliate determines that any federal,
state, local, or foreign tax or withholding payment is required relating to the MSUs, or the delivery of Shares with respect to this Award,
the Company or any Affiliate, subject to the proviso below, will have the right to withhold the delivery of vested Shares otherwise deliverable
under this Agreement to meet such obligations, provided that, fractional Shares will not be retained to satisfy any portion of the Company's
withholding obligation (such process, "**Net Settlement** "); provided, however, subject to the terms of the Company's
Insider Trading Policy, the Administrator shall have the discretion to override Net Settlement, (i) provided ninety (90) days'
advance notice is given prior to the Vesting Date from the Company to the Participant, in which case such withholding shall be through
a "same day sale" commitment with a broker-dealer that is a member of the Financial Industry Regulatory Authority (a "**FINRA Dealer** "), whereby the Participant irrevocably elects to sell a portion of the Shares to be delivered in connection with the
MSUs to satisfy withholding obligations and whereby the FINRA Dealer irrevocably commits to forward the proceeds necessary to satisfy
the withholding obligations directly to the Company or any Affiliate ()"**Sell to Cover**") or (ii)(A) in lieu of withholding
(under Net Settlement) or selling (under Sell to Cover) a fractional vested Share or (B) in connection with withholding obligations
arising outside the ordinary course, such as outside the regular Vesting Date of the MSUs, and in each case under (A) or (B) such
withholding may be through deduction from payments of any kind otherwise due to the Participant.

The Participant hereby (i) agrees that the Company or any Affiliate shall be entitled to use the foregoing methods to recover such taxes and (ii) acknowledges that, absent further action by the Administrator, in the event that the Company or an Affiliate determines that any federal, state, local, or foreign tax or withholding payment is required relating to the MSUs, or the delivery of Shares with respect to this Award, the Company or any Affiliate will utilize Net Settlement.

The Participant further agrees that the Administrator may, as it reasonably considers necessary, amend or vary this Agreement due to changes in tax laws to facilitate such recovery of taxes.

13. <u>Participant Acknowledgements and Authorizations</u>. The Participant hereby acknowledges the following:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Neither the Company nor any Affiliate is, by the Plan or this Award, obligated to continue the Participant
as an employee, director, or consultant of the Company or an Affiliate. Unless otherwise specified in a written employment or other written
compensatory agreement between the Participant and the Company or an Affiliate, the Company or any Affiliate, as applicable, reserves
the right to terminate the Participant's employment or other service relationship with the Company or an Affiliate at any time and
for any reason.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) The Plan is discretionary in nature and may be suspended or terminated by the Company at any time.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) The grant of this Award is considered a one-time benefit and does not create a contractual or other right
to receive any other award under the Plan, benefits in lieu of awards, or any other benefits in the future.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) The Plan is a voluntary program of the Company and future awards, if any, will be at the sole discretion
of the Company, including, but not limited to, the timing of any grant, the amount of any award, vesting provisions, and the purchase
price, if any.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) The value of this Award is an extraordinary item of compensation outside of the scope of the Participant's
employment or consulting contract, agreement, or arrangement. As such, the Award is not part of normal or expected compensation
for purposes of calculating any severance, resignation, redundancy, end of service payments, bonuses, long-service awards, pension or
retirement benefits, or similar payments. The future value of the shares of Common Stock is unknown and cannot be predicted with
certainty.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) The Participant (i) authorizes the Company and each Affiliate and any agent of the Company or any
Affiliate administering the Plan or providing Plan recordkeeping services to disclose to the Company or any of its Affiliates such information
and data as the Company or any such Affiliate shall request in order to facilitate the grant of the Award and the administration of the
Plan; and (ii) authorizes the Company and each Affiliate to store and transmit such information in electronic form for the purposes
set forth in this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) The obligation of the Company to deliver Shares pursuant to this Award constitutes an unfunded and unsecured
obligation of the Company. Until Shares are delivered, the Participant shall have no rights under this Agreement or the Plan, other than
those of a general unsecured creditor of the Company. No assets of the Company shall be set aside for the settlement of the MSUs.

14. <u>Notices</u>. By accepting the Award, the Participant agrees that notices may be given to the Participant
in writing either at the Participant's home or mailing address as shown in the records of the Company or an Affiliate or by electronic
transmission (including e-mail or reference to a website or other URL) sent to the Participant through the normal process employed by
the Company or the Affiliate, as applicable, for communicating electronically with its employees or other service providers.

15. <u>Assignment and Successors</u>.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) This Agreement is personal to the Participant and, without the prior written approval of the Administrator,
shall not be assignable by the Participant, other than by will or the laws of descent and distribution. This Agreement shall inure
to the benefit of and be enforceable by the Participant's legal representatives and beneficiaries.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) This Agreement shall inure to the benefit of and be binding upon the Company and its successors and assigns.

16. <u>Governing Law</u>. This Agreement shall be construed and enforced in accordance with the laws
of the State of Delaware, without giving effect to the conflict of law principles thereof; provided that, for the avoidance of doubt,
the Restrictive Covenants shall continue to be governed solely by Pennsylvania law. For the purpose of litigating any dispute that
arises under this Agreement, whether at law or in equity, the parties hereby consent to exclusive jurisdiction in the Commonwealth of
Pennsylvania and agree that such litigation shall be conducted in the state courts of the Commonwealth of Pennsylvania or the federal
courts of the United States for the Eastern District of Pennsylvania.

17. <u>Severability</u>. If any provision of this Agreement is held to be invalid or unenforceable by
a court of competent jurisdiction, then such provision or provisions shall be modified to the extent necessary to make such provision
valid and enforceable, and to the extent that this is impossible, then such provision shall be deemed to be excised from this Agreement,
and the validity, legality, and enforceability of the rest of this Agreement shall not be affected thereby.

18. <u>Entire Agreement</u>. This Agreement, together with the Grant Notice, the Restrictive Covenants,
and the Plan, constitutes the entire agreement and understanding between the parties hereto with respect to the subject matter hereof
and supersedes all prior oral or written agreements and understandings relating to the subject matter hereof, including without limitation
any offer letter provision related to the subject matter hereof. No statement, representation, warranty, covenant, or agreement
not expressly set forth in this Agreement shall affect or be used to interpret, change, or restrict the express terms and provisions of
this Agreement; provided, however, in any event, this Agreement shall be subject to and governed by the Plan.

19. <u>Modifications and Amendments; Waivers and Consents</u>. The terms and provisions of this Agreement
may be modified or amended as provided in the Plan. Except as provided in the Plan, the terms and provisions of this Agreement may
be waived, or consent for the departure therefrom granted, only by written document executed by the party entitled to the benefits of
such terms or provisions. No such waiver or consent shall be deemed to be or shall constitute a waiver or consent with respect to
any other terms or provisions of this Agreement, whether or not similar. Each such waiver or consent shall be effective only in the specific
instance and for the purpose for which it was given, and shall not constitute a continuing waiver or consent.

20. <u>Code Section 409A</u>. The Award of MSUs evidenced by this Agreement is intended to be exempt
from the nonqualified deferred compensation rules of Code Section 409A as a "short-term deferral" within the meaning
of Code Section 409A and, to the maximum extent permitted, shall be construed accordingly. Notwithstanding anything to the contrary
in the Plan or this Agreement, none of the Company, its Affiliates, the Board of Directors, the Administrator, or any of their respective
agents or delegates will have any obligation to take any action to prevent the assessment of any excise tax or penalty on the Participant
under Code Section 409A, and none of the Company, its Affiliates, the Board of Directors, the Administrator, or any of their respective
agents or delegates will have any liability to the Participant or any other person for such tax or penalty.

To the extent that the MSUs constitute "deferred compensation" under Code Section 409A, a Termination shall be deemed to occur only upon an event that such Termination is a "separation from service" within the meaning of Code Section 409A. If, at the time of the Participant's "separation from service," (i) the Participant is a "specified employee" within the meaning of Code Section 409A (and as applied according to procedures of the Company and its Affiliates), and (ii) the Administrator makes a good faith determination that an amount payable under this Agreement on account of the Participant's separation from service constitutes non-qualified deferred compensation (within the meaning of Code Section 409A), the payment of which is required to be delayed pursuant to the six (6)-month delay rule set forth in Code Section 409A to avoid taxes or penalties under Code Section 409A (the "**Delay Period**"), then the Company will not pay such amount on the otherwise scheduled payment date but will instead pay it in a lump sum on the first business day after the Delay Period (or upon the Participant's death, if earlier), without interest. Each installment of MSUs that vest under this Agreement (if there is more than one installment) will be considered one of a series of separate payments for purposes of Code Section 409A.

21. <u>Data Privacy</u>. By entering into this Agreement, the Participant: (i) authorizes the Company
and each Affiliate, and any agent of the Company or any Affiliate administering the Plan or providing Plan recordkeeping services, to
disclose to the Company or any of its Affiliates such information and data as the Company or any such Affiliate shall request in order
to facilitate the grant of restricted stock units and the administration of the Plan; and (ii) authorizes the Company and each Affiliate
to store and transmit such information in electronic form for the purposes set forth in this Agreement.

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## Ex-Filing

?xml version='1.0' encoding='ASCII'? EX-FILING FEES

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| |
|:---|
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Calculation of Filing Fee Tables**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **S-8**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **MADRIGAL PHARMACEUTICALS, INC.**  |

---

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Security Type**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Security Class Title**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Fee Calculation Rule**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Amount Registered**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Proposed Maximum Offering Price Per Unit**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Maximum Aggregate Offering Price**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Fee Rate**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Amount of Registration Fee**  |
| 1 | Equity | Common Stock, $0.0001 par value per share | Other | 100000 | $280.85 | $28085000.00 | 0.0001531 | $4299.81 |
| Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: |  | $28085000.00  |  | $4299.81  |
| Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  |  |  |  | $0.00  |
| Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  |  |  |  | $4299.81  |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Offering Note** <br>

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <sup>1</sup> (1) Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement on Form S-8 ("Registration Statement") shall also cover any additional shares of common stock, $0.0001 par value per share (the "Common Stock") of Madrigal Pharmaceuticals, Inc. (the "Registrant") that become issuable under the Madrigal Pharmaceuticals, Inc. 2025 Inducement Stock Plan (the "Plan"), by reason of any stock dividend, stock split, recapitalization or any other similar transactions. (2) Represents shares of Common Stock available for future issuance under the Plan. (3) Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457 of the Securities Act, and based on $280.85, the average of the high and low sale prices of the Common Stock as reported on Nasdaq on June 17, 2025 (such date being within five business days of the date that this Registration Statement was filed with the Commission).