# EDGAR Filing Document

**Accession Number:** 0001861560
**File Stem:** 0001193125-26-073340
**Filing Date:** 2026-2
**Character Count:** 17682
**Document Hash:** d3a2f7f9a1fbe7d7f856f22094f4306f
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-26-073340.hdr.sgml**: 20260226

**ACCESSION NUMBER**: 0001193125-26-073340

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 16

**FILED AS OF DATE**: 20260226

**DATE AS OF CHANGE**: 20260226

**EFFECTIVENESS DATE**: 20260226

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Nuvalent, Inc.
- **CENTRAL INDEX KEY:** 0001861560
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-293769
- **FILM NUMBER:** 26681604

**BUSINESS ADDRESS:**
- **STREET 1:** ONE BROADWAY, 14TH FLOOR
- **CITY:** CAMBRIDGE
- **STATE:** MA
- **ZIP:** 02142
- **BUSINESS PHONE:** 508-446-2272

**MAIL ADDRESS:**
- **STREET 1:** ONE BROADWAY, 14TH FLOOR
- **CITY:** CAMBRIDGE
- **STATE:** MA
- **ZIP:** 02142

**As filed with the Securities and Exchange Commission on February 26, 2026** 

**Registration No. 333-** 

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**Washington, D.C. 20549** 

**FORM S-8** 

**REGISTRATION STATEMENT** 

***Under***

***The Securities Act of 1933***

## NUVALENT, INC.
**(Exact name of registrant as specified in its charter)** 

---

| | |
|:---|:---|
| **Delaware** | **81-5112298** |
| **(State or other jurisdiction of**<br> **incorporation or organization)** | **(I.R.S. Employer**<br> **Identification No.)** |

---

**One Broadway, 14th Floor** 

**Cambridge, MA 02142** 

**(Address, including zip code, of Registrant's principal executive offices)** 

**Nuvalent, Inc. 2021 Stock Option and Incentive Plan** 

**Nuvalent, Inc. Amended and Restated 2021 Employee Stock Purchase Plan** 

**(Full title of the plan)** 

**James R. Porter** 

**Chief Executive Officer** 

**One Broadway, 14th Floor** 

**Cambridge, MA 02142** 

**(857) 357-7000** 

**(Name, address, including zip code, and telephone number, including area code, of agent for service)** 

***with copies to:***

---

| | |
|:---|:---|
| **Deborah Miller**<br> **Chief Legal Officer**<br> **One Broadway, 14th Floor**<br> **Cambridge, MA 02142**<br> **(857) 357-7000** | **Rosemary G. Reilly, Esq.**<br> **Sidley Austin LLP**<br> **60 State Street, 36th Floor**<br> **Boston, Massachusetts 02109**<br> **(617) 223-0300** |

---

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☒ | Accelerated filer | ☐ |
|  Non-accelerated filer | ☐ | Smaller reporting company | ☐ |
|  |  | Emerging growth company | ☐ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

------

**Statement of Incorporation by Reference** 

This Registration Statement on Form S-8, relating to the 2021 Stock Option and Incentive Plan (the "2021 Plan") and the Amended and Restated 2021 Employee Stock Purchase Plan (the "2021 ESPP") of Nuvalent, Inc. (the "Registrant"), is being filed for the purpose of registering additional securities of the same class as other securities for which a Registration Statement on Form S-8 relating to the 2021 Plan and the 2021 ESPP has previously been filed and is effective. Pursuant to General Instruction E to Form S-8, except as otherwise set forth below, this Registration Statement incorporates by reference the contents of (i) the Registration Statement on Form S-8, File No. <u>[333-258237](http://www.sec.gov/Archives/edgar/data/1861560/000119312521227573/d198428ds8.htm)</u>, relating to the 2021 Plan and the 2021 ESPP filed by the Registrant with the Securities and Exchange Commission on July 28, 2021, (ii) the Registration Statement on Form S-8, File No. [<u>333-263926</u>](http://www.sec.gov/Archives/edgar/data/1861560/000119312522087414/d305461ds8.htm), relating to the 2021 Plan and the 2021 ESPP filed by the Registrant with the Securities and Exchange Commission on March 29, 2022, (iii) the Registration Statement on Form S-8, File No. <u>[333-270594](http://www.sec.gov/Archives/edgar/data/1861560/000119312523071976/d455933ds8.htm)</u>, relating to the 2021 Plan and the 2021 ESPP filed by the Registrant with the Securities and Exchange Commission on March 16, 2023, (iv) the Registration Statement on Form S-8, File No. [<u>333-277379</u>](http://www.sec.gov/Archives/edgar/data/1861560/000119312524047028/d779850ds8.htm), relating to the 2021 Plan and the 2021 ESPP filed by the Registrant with the Securities and Exchange Commission on February 27, 2024, and (v) the Registration Statement on Form S-8, File No. <u>[333-285299](http://www.sec.gov/Archives/edgar/data/1861560/000119312525037582/d904176ds8.htm)</u>, relating to the 2021 Plan and the 2021 ESPP filed by the Registrant with the Securities and Exchange Commission on February 27, 2025.

 **Item 8. Exhibits.**<br>

The following exhibits are incorporated herein by reference:

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| **Exhibit<br>Number** | **Description of Exhibit** | **Form** | **File No.** | **Exhibit** | **Filing Date** | **Filed**<br> **Herewith** |
| 4.1 | [Third Amended and Restated Certificate of Incorporation of the Registrant, as amended](http://www.sec.gov/Archives/edgar/data/1861560/000095017023028601/nuvl-ex3_1.htm) | 8-K | 001-40671 | 3.1 | 6/16/2023 |  |
| 4.2 | [Amended and Restated Bylaws of the Registrant](http://www.sec.gov/Archives/edgar/data/1861560/000095017023008284/nuvl-ex3_2.htm) | 10-K | 001-40671 | 3.2 | 3/16/2023 |  |
| 4.3 | [Amended and Restated Investors' Rights Agreement among the Registrant and certain of its stockholders, effective as of April 30, 2021](http://www.sec.gov/Archives/edgar/data/1861560/000119312521209001/d174530dex43.htm) | S-1 | 333-257730 | 4.3 | 7/7/2021 |  |
| 5.1 | [Opinion of Sidley Austin LLP](d946720dex51.htm) |  |  |  |  | X |
| 23.1 | [Consent of KPMG LLP, independent registered public accounting firm](d946720dex231.htm) |  |  |  |  | X |
| 23.2 | [Consent of Sidley Austin LLP (included in Exhibit 5.1)](d946720dex51.htm) |  |  |  |  | X |
| 24.1 | [Power of Attorney (included on the signature pages of this registration statement)](#sig) |  |  |  |  | X |
| 99.1 | [2021 Stock Option and Incentive Plan and forms of award agreements thereunder](http://www.sec.gov/Archives/edgar/data/1861560/000119312521223640/d174530dex102.htm) | S-1/A | 333-257730 | 10.2 | 7/26/2021 |  |
| 99.2 | [Amended and Restated 2021 Employee Stock Purchase Plan](http://www.sec.gov/Archives/edgar/data/1861560/000119312522216780/d295365dex101.htm) | 10-Q | 001-40671 | 10.1 | 8/10/2022 |  |
| 107 | [Filing Fee Table](d946720dexfilingfees.htm) |  |  |  |  | X |

---

------

**SIGNATURES** 

Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Cambridge, Commonwealth of Massachusetts, on this 26th day of February, 2026.

---

| | |
|:---|:---|
| **NUVALENT, INC.** | **NUVALENT, INC.** |
| By: | /s/ James R. Porter |
|  | Name: James R. Porter, Ph.D. |
|  | Title: President and Chief Executive Officer |

---

**POWER OF ATTORNEY AND SIGNATURES** 

KNOW ALL BY THESE PRESENT, that each individual whose signature appears below hereby constitutes and appoints each of James R. Porter, Alexandra Balcom and Deborah Miller as such person's true and lawful attorney-in-fact and agent with full power of substitution and resubstitution, for such person in such person's name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this registration statement on Form S-8, and to file the same, with all exhibits thereto, and all documents in connection therewith, with the Securities and Exchange Commission granting unto each said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as such person might or could do in person, hereby ratifying and confirming all that any said attorney-in-fact and agent, or any substitute or substitutes of any of them, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated.

------

---

| | | |
|:---|:---|:---|
| **Name** | **Title** | **Date** |
| /s/ James R. Porter<br> James R. Porter, Ph.D. | President, Chief Executive Officer and Director<br> (*Principal Executive Officer*) | February 26, 2026 |
| /s/ Alexandra Balcom<br> Alexandra Balcom | Chief Financial Officer<br> (*Principal Financial Officer and Principal Accounting Officer*) | February 26, 2026 |
| /s/ Grant Bogle<br> Grant Bogle | Director | February 26, 2026 |
| /s/ Michael L. Meyers<br> Michael L. Meyers, M.D., Ph.D. | Director | February 26, 2026 |
| /s/ Christy Oliger<br> Christy Oliger | Director | February 26, 2026 |
| /s/ Joseph Pearlberg<br> Joseph Pearlberg, M.D., Ph.D. | Director | February 26, 2026 |
| /s/ Anna Protopapas<br> Anna Protopapas | Director | February 26, 2026 |
| /s/ Ron Squarer<br> Ron Squarer | Director | February 26, 2026 |
| /s/ Sapna Srivastava<br> Sapna Srivastava, Ph.D. | Director | February 26, 2026 |
| /s/ Cameron A. Wheeler<br> Cameron A. Wheeler, Ph.D. | Director | February 26, 2026 |

---

## Exhibit 5.1

**Exhibit 5.1** 

---

| | |
|:---|:---|
| ![LOGO](g946720g0223183219029.jpg) | SIDLEY AUSTIN (NE) LLP |
| ![LOGO](g946720g0223183219029.jpg) | 60 STATE STREET, 36TH FLOOR |
| ![LOGO](g946720g0223183219029.jpg) | BOSTON, MASSACHUSETTS 02109 |
| ![LOGO](g946720g0223183219029.jpg) | +1 617 223 0300 |
| ![LOGO](g946720g0223183219029.jpg) | +1 617 223 0301 FAX |

---

February 26, 2026

Nuvalent, Inc.

One Broadway, 14th Floor

Cambridge, MA 02142

Re: <u>2021 Stock Option and Incentive Plan; Amended and Restated 2021 Employee Stock Purchase Plan</u>

Ladies and Gentlemen:

We refer to the Registration Statement on Form S-8 (the "<u>Registration Statement</u>") being filed by Nuvalent, Inc., a Delaware corporation (the "<u>Company</u>"), with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the "<u>Securities Act</u>"), relating to the registration of (i) 3,911,968 shares of Class A common stock, $0.0001 par value per share, of the Company ("<u>Common Stock</u>"), which may be issued under the Company's 2021 Stock Option and Incentive Plan (the "<u>Stock Option Plan</u>") and (ii) 473,064 shares of Common Stock, which may be issued under the Company's Amended and Restated 2021 Employee Stock Purchase Plan (together with the Stock Option Plan, the "<u>Plans</u>," and the aggregate number of shares of Common Stock to be registered under the Registration Statement, the "<u>Registered Shares</u>").

This opinion letter is being delivered in accordance with the requirements of Item 601(b)(5) of Regulation S-K under the Securities Act.

We have examined the Registration Statement, the Company's certificate of incorporation, the Plans, the resolutions adopted by the board of directors of the Company relating to the Registration Statement and the Plans, and the resolutions adopted by the stockholders of the Company relating to the Plans. We have also examined originals, or copies of originals certified to our satisfaction, of such agreements, documents, certificates and statements of the Company and other corporate documents and instruments, and have examined such questions of law, as we have considered relevant and necessary as a basis for this opinion letter. We have assumed the authenticity of all documents submitted to us as originals, the genuineness of all signatures, the legal capacity of all persons and the conformity with the original documents of any copies thereof submitted to us for examination. As to facts relevant to the opinions expressed herein, we have relied without independent investigation or verification upon, and assumed the accuracy and completeness of, certificates, letters and oral and written statements and representations of public officials and officers and other representatives of the Company.

Based on the foregoing, we are of the opinion that each Registered Share that is newly issued pursuant to the Plans will be validly issued, fully paid and non-assessable when: (i) the Registration Statement, as finally amended, shall have become effective under the Securities Act; (ii) such Registered Share shall have been duly issued and delivered in accordance with the Plans; and (iii) certificates representing such Registered Share shall have been duly executed, countersigned and registered and duly delivered to the person entitled thereto against payment of the agreed consideration therefor or, if any Registered Share is to be issued in uncertificated form, the Company's books shall reflect the issuance of such Registered Share to the person entitled thereto against payment of the agreed consideration therefor, all in accordance with the Plans.

*Sidley Austin (NE) LLP is a Delaware limited liability partnership doing business as Sidley Austin LLP and practicing in affiliation with other Sidley Austin partnerships.* 

------

![LOGO](g946720g0223183219029.jpg)

Nuvalent, Inc.

February 26, 2026

This opinion letter is limited to the General Corporation Law of the State of Delaware. We express no opinion as to the laws, rules or regulations of any other jurisdiction, including, without limitation, the federal laws of the United States of America or any state securities or blue sky laws.

We hereby consent to the filing of this opinion letter as an Exhibit to the Registration Statement and to all references to our Firm included in or made a part of the Registration Statement. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act.

---

| |
|:---|
| Very truly yours, |
| /s/ Sidley Austin LLP |

---

## Exhibit 23.1

**Exhibit 23.1** 

---

| | |
|:---|:---|
| ![LOGO](g946720dsp08.jpg) |  |
|  | KPMG LLP<br> Two Financial Center<br> 60 South Street<br> Boston, MA 02111 |

---

**Consent of Independent Registered Public Accounting Firm** 

We consent to the use of our report dated February 26, 2026, with respect to the consolidated financial statements of Nuvalent, Inc., and the effectiveness of internal control over financial reporting, incorporated herein by reference.

/s/ KPMG LLP

Boston, Massachusetts

February 26, 2026

KPMG LLP, a Delaware limited liability partnership, and its subsidiaries are part of the KPMG global organization of independent member firms affiliated with KPMG International Limited, a private English company limited by guarantee.

## Ex-Filing

?xml version='1.0' encoding='ASCII'? EX-FILING FEES

---

| |
|:---|
| **Calculation of Filing Fee Tables**  |
| &nbsp;&nbsp;&nbsp;&nbsp;**S-8**  |
| &nbsp;&nbsp;&nbsp;&nbsp;**Nuvalent, Inc.**  |

---

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | **Security Type**  | **Security Class Title**  | **Fee Calculation Rule**  | **Amount Registered**  | **Proposed Maximum Offering Price Per Unit**  | **Maximum Aggregate Offering Price**  | **Fee Rate**  | **Amount of Registration Fee**  |
| 1 | Equity | Class A common stock, par value $0.0001 per share | Other | 4385032 | $101.60 | $445519251.20 | 0.0001381 | $61526.21 |
| Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: |  | $445519251.20  |  | $61526.21  |
| Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  |  |  |  | $0.00  |
| Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  |  |  |  | $61526.21  |

---

 **Offering Note** <br>

<sup>1</sup> (i) In accordance with Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this registration statement shall be deemed to cover any additional securities that may from time to time be offered or issued to prevent dilution resulting from stock splits, stock dividends or similar transactions. (ii) Consists of (i) 3,911,968 additional shares issuable under the 2021 Stock Option and Incentive Plan and (ii) 473,064 additional shares issuable under the Amended and Restated 2021 Employee Stock Purchase Plan. (iii) Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and 457(h) of the Securities Act and based upon the average of the high and low sales price of the Registrant's Class A common stock on the Nasdaq Global Select Market on February 20, 2026.

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| | |
|:---|:---|
| | |
| **Rule 457(p)** | **Rule 457(p)** |
| Fee Offset Claims | N/A |
| Fee Offset Sources | N/A |

---