# EDGAR Filing Document

**Accession Number:** 0001892134
**File Stem:** 0001420506-23-000230
**Filing Date:** 2023-2
**Character Count:** 8179
**Document Hash:** d71cc748e1419417ad2932bdeabce003
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001420506-23-000230.hdr.sgml**: 20230203

**ACCESSION NUMBER**: 0001420506-23-000230

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230203

**DATE AS OF CHANGE**: 20230203

**EFFECTIVENESS DATE**: 20230203

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Frazier Life Sciences Management, L.P.
- **CENTRAL INDEX KEY:** 0001892134
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-22504
- **FILM NUMBER:** 23585598

**BUSINESS ADDRESS:**
- **STREET 1:** 70 WILLOW ROAD, SUITE 200
- **CITY:** MENLO PARK
- **STATE:** CA
- **ZIP:** 94025
- **BUSINESS PHONE:** (206) 621-7200

**MAIL ADDRESS:**
- **STREET 1:** 70 WILLOW ROAD, SUITE 200
- **CITY:** MENLO PARK
- **STATE:** CA
- **ZIP:** 94025

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2022

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** Frazier Life Sciences Management L.P.<br>**Address:** 70 Willow Road Suite 200<br>Menlo Park, CA 94025

**Form 13F File Number:** 028-22504

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Steve R. Bailey<br>**Title:** Chief Financial Officer and Chief Compliance Officer<br>**Phone:** (206) 621-7200

**Signature, Place, and Date of Signing:**

Steve R. Bailey Chief Financial Officer and Chief Compliance Officer  Menlo Park, CA  02-03-2023<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 44

**Form 13F Information Table Value Total:** $1608433

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 |  | 13649 | 857338 | SH |  | SOLE |  | 857338 | 0 | 0 |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 |  | 4570 | 290189 | SH |  | SOLE |  | 290189 | 0 | 0 |
| ALLAKOS INC | COM | 01671P100 |  | 40349 | 4792000 | SH |  | SOLE |  | 4792000 | 0 | 0 |
| ALPINE IMMUNE SCIENCES INC | COM | 02083G100 |  | 21945 | 2985757 | SH |  | SOLE |  | 2985757 | 0 | 0 |
| ANAPTYSBIO INC | COM | 032724106 |  | 27882 | 899700 | SH |  | SOLE |  | 899700 | 0 | 0 |
| APTINYX INC | COM | 03836N103 |  | 537 | 1883244 | SH |  | SOLE |  | 1883244 | 0 | 0 |
| ARVINAS INC | COM | 04335A105 |  | 9761 | 285331 | SH |  | SOLE |  | 285331 | 0 | 0 |
| AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 |  | 7119 | 3746857 | SH |  | SOLE |  | 3746857 | 0 | 0 |
| AVIDITY BIOSCIENCES INC | COM | 05370A108 |  | 11095 | 500000 | SH |  | SOLE |  | 500000 | 0 | 0 |
| Arcutis Biotherapeutics | COM | 03969K108 |  | 128527 | 8684232 | SH |  | SOLE |  | 8684232 | 0 | 0 |
| BLUEBIRD BIO INC | COM | 09609G100 |  | 9970 | 1440757 | SH |  | SOLE |  | 1440757 | 0 | 0 |
| CEREVEL THERAPEUTICS HLDNG I | COM | 15678U128 |  | 12395 | 393000 | SH |  | SOLE |  | 393000 | 0 | 0 |
| CHINOOK THERAPEUTICS INC | COM | 16961L106 |  | 113854 | 4345559 | SH |  | SOLE |  | 4345559 | 0 | 0 |
| COGENT BIOSCIENCES INC | COM | 19240Q201 |  | 24382 | 2109154 | SH |  | SOLE |  | 2109154 | 0 | 0 |
| CRINETICS PHARMACEUTICALS IN | COM | 22663K107 |  | 25891 | 1414823 | SH |  | SOLE |  | 1414823 | 0 | 0 |
| ESSA Pharma Inc. | COM NEW | 29668H708 |  | 1525 | 605141 | SH |  | SOLE |  | 605141 | 0 | 0 |
| GRITSTONE BIO INC | COM | 39868T105 |  | 17810 | 5162348 | SH |  | SOLE |  | 5162348 | 0 | 0 |
| HILLEVAX INC | COM | 43157M102 |  | 163257 | 9758359 | SH |  | SOLE |  | 9758359 | 0 | 0 |
| IMAGO BIOSCIENCES INC | COM | 45250K107 |  | 143340 | 3987207 | SH |  | SOLE |  | 3987207 | 0 | 0 |
| INTELLIA THERAPEUTICS INC | COM | 45826J105 |  | 7107 | 203684 | SH |  | SOLE |  | 203684 | 0 | 0 |
| Immunovant Inc. | COM | 45258J102 |  | 10397 | 585759 | SH |  | SOLE |  | 585759 | 0 | 0 |
| KALVISTA PHARMACEUTICALS INC | COM | 483497103 |  | 21895 | 3238859 | SH |  | SOLE |  | 3238859 | 0 | 0 |
| KRYSTAL BIOTECH INC | COM | 501147102 |  | 79199 | 999737 | SH |  | SOLE |  | 999737 | 0 | 0 |
| MERUS N V | COM | N5749R100 |  | 11548 | 746479 | SH |  | SOLE |  | 746479 | 0 | 0 |
| Mirum Pharmaceuticals Inc. | COM | 604749101 |  | 75272 | 3860107 | SH |  | SOLE |  | 3860107 | 0 | 0 |
| NABRIVA THERAPEUTICS PLC | SHS NEW 2022 | G63637139 |  | 32 | 17025 | SH |  | SOLE |  | 17025 | 0 | 0 |
| NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | N62509109 |  | 101823 | 9341551 | SH |  | SOLE |  | 9341551 | 0 | 0 |
| NEWAMSTERDAM PHARMA COMPANY | *W EXP 11/22/202 | N62509117 |  | 434 | 500333 | SH |  | SOLE |  | 500333 | 0 | 0 |
| PROTHENA CORP PLC | SHS | G72800108 |  | 7706 | 127900 | SH |  | SOLE |  | 127900 | 0 | 0 |
| Passage Bio Inc. | COM | 702712100 |  | 5185 | 3756915 | SH |  | SOLE |  | 3756915 | 0 | 0 |
| Phathom Pharmaceuticals Inc. | COM | 71722W107 |  | 94328 | 8407152 | SH |  | SOLE |  | 8407152 | 0 | 0 |
| REPLIMUNE GROUP INC | COM | 76029N106 |  | 25338 | 931560 | SH |  | SOLE |  | 931560 | 0 | 0 |
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 |  | 55153 | 1894000 | SH |  | SOLE |  | 1894000 | 0 | 0 |
| SILENCE THERAPEUTICS PLC | ADS | 82686Q101 |  | 13438 | 881173 | SH |  | SOLE |  | 881173 | 0 | 0 |
| SUTRO BIOPHARMA INC | COM | 869367102 |  | 14354 | 1776479 | SH |  | SOLE |  | 1776479 | 0 | 0 |
| Syndax Pharmaceuticals Inc. | COM | 87164F105 |  | 94390 | 3708838 | SH |  | SOLE |  | 3708838 | 0 | 0 |
| THESEUS PHARMACEUTICALS INC | COM | 88369M101 |  | 6963 | 1398194 | SH |  | SOLE |  | 1398194 | 0 | 0 |
| TREVI THERAPEUTICS INC | COM | 89532M101 |  | 12861 | 6663590 | SH |  | SOLE |  | 6663590 | 0 | 0 |
| TYRA BIOSCIENCES INC | COM | 90240B106 |  | 10090 | 1327665 | SH |  | SOLE |  | 1327665 | 0 | 0 |
| Tarsus Pharmaceuticals Inc. | COM | 87650L103 |  | 26205 | 1787527 | SH |  | SOLE |  | 1787527 | 0 | 0 |
| VECTIVBIO HLDG AG | ORD SHS | H9060V101 |  | 11481 | 1333400 | SH |  | SOLE |  | 1333400 | 0 | 0 |
| VERONA PHARMA PLC | SPONSORED ADS | 925050106 |  | 73575 | 2815720 | SH |  | SOLE |  | 2815720 | 0 | 0 |
| Vaxcyte Inc. | COM | 92243G108 |  | 67006 | 1397405 | SH |  | SOLE |  | 1397405 | 0 | 0 |
| ZYMEWORKS DEL INC | COM | 98985Y108 |  | 4795 | 610000 | SH |  | SOLE |  | 610000 | 0 | 0 |

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