# EDGAR Filing Document

**Accession Number:** 0001493215
**File Stem:** 0001493215-26-000130
**Filing Date:** 2026-5
**Character Count:** 12979
**Document Hash:** f0fc068d37d45e6ed2680062047909c8
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001493215-26-000130.hdr.sgml**: 20260515

**ACCESSION NUMBER**: 0001493215-26-000130

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20260331

**FILED AS OF DATE**: 20260515

**DATE AS OF CHANGE**: 20260515

**EFFECTIVENESS DATE**: 20260515

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** RTW INVESTMENTS, LP
- **CENTRAL INDEX KEY:** 0001493215

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-16670
- **FILM NUMBER:** 26982702

**BUSINESS ADDRESS:**
- **STREET 1:** 40 10TH AVENUE
- **STREET 2:** 7TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10014
- **BUSINESS PHONE:** 646-597-6980

**MAIL ADDRESS:**
- **STREET 1:** 40 10TH AVENUE
- **STREET 2:** 7TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10014

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** RTW INVESTMENTS, LLC
- **DATE OF NAME CHANGE:** 20100602

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 03-31-2026

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** RTW INVESTMENTS LP<br>**Address:** 40 10TH AVENUE<br>7TH FLOOR<br>NEW YORK, NY 10014

**Form 13F File Number:** 028-16670

**CRD Number (if applicable):** 000153232

**SEC File Number (if applicable):** 801-78183

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Roderick Wong<br>**Title:** Managing Partner<br>**Phone:** 646-597-6980

**Signature, Place, and Date of Signing:**

/s/ Roderick Wong  NEW YORK, NY  05-15-2026<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 88

**Form 13F Information Table Value Total:** $10049752600

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| 4D MOLECULAR THERAPEUTICS IN | COM | 35104E100 |  | 4429111 | 475737 | SH |  | SOLE |  | 475737 | 0 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 |  | 159037104 | 7144524 | SH |  | SOLE |  | 7144524 | 0 | 0 |
| AKTIS ONCOLOGY INC | COM | 01021M104 |  | 28481649 | 1592043 | SH |  | SOLE |  | 1592043 | 0 | 0 |
| ALKERMES PLC | SHS | G01767105 |  | 59134508 | 1672356 | SH |  | SOLE |  | 1672356 | 0 | 0 |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 |  | 148249360 | 3685045 | SH |  | SOLE |  | 3685045 | 0 | 0 |
| APOGEE THERAPEUTICS INC | COM | 03770N101 |  | 234169104 | 2782097 | SH |  | SOLE |  | 2782097 | 0 | 0 |
| AQUESTIVE THERAPEUTICS INC | COM | 03843E104 |  | 30819855 | 7426471 | SH |  | SOLE |  | 7426471 | 0 | 0 |
| ARGENX SE | SPONSORED ADR | 04016X101 |  | 518072942 | 709446 | SH |  | SOLE |  | 709446 | 0 | 0 |
| ARROWHEAD PHARMACEUTICALS IN | COM | 04280A100 |  | 36722261 | 585682 | SH |  | SOLE |  | 585682 | 0 | 0 |
| ATAIBECKLEY INC | COM SHS | 04650F101 |  | 7080000 | 2000000 | SH |  | SOLE |  | 2000000 | 0 | 0 |
| AVALO THERAPEUTICS INC | COM NEW | 05338F306 |  | 12794443 | 856962 | SH |  | SOLE |  | 856962 | 0 | 0 |
| BEAM THERAPEUTICS INC | COM | 07373V105 |  | 13592489 | 570394 | SH |  | SOLE |  | 570394 | 0 | 0 |
| BELITE BIO INC | SPONSORED ADS | 07782B104 |  | 114052534 | 715332 | SH |  | SOLE |  | 715332 | 0 | 0 |
| BETA BIONICS INC | COM | 08659B102 |  | 20040000 | 2000000 | SH |  | SOLE |  | 2000000 | 0 | 0 |
| CANDEL THERAPEUTICS INC | COM | 137404109 |  | 31467888 | 6422018 | SH |  | SOLE |  | 6422018 | 0 | 0 |
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 |  | 7600000 | 250000 | SH |  | SOLE |  | 250000 | 0 | 0 |
| CASTLE BIOSCIENCES INC | COM | 14843C105 |  | 67717124 | 2758335 | SH |  | SOLE |  | 2758335 | 0 | 0 |
| CELCUITY INC | COM | 15102K100 |  | 346942341 | 3039621 | SH |  | SOLE |  | 3039621 | 0 | 0 |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 |  | 81591831 | 2054175 | SH |  | SOLE |  | 2054175 | 0 | 0 |
| CENTURY THERAPEUTICS INC | COM | 15673T100 |  | 19652174 | 8695652 | SH |  | SOLE |  | 8695652 | 0 | 0 |
| CG ONCOLOGY INC | COM | 156944100 |  | 472731805 | 6984808 | SH |  | SOLE |  | 6984808 | 0 | 0 |
| COGENT BIOSCIENCES INC | COM | 19240Q201 |  | 210104401 | 5458675 | SH |  | SOLE |  | 5458675 | 0 | 0 |
| COMPASS PATHWAYS PLC | SPONSORED ADS | 20451W101 |  | 58797117 | 10632390 | SH |  | SOLE |  | 10632390 | 0 | 0 |
| COMPASS THERAPEUTICS INC | COM | 20454B104 |  | 22147109 | 4186599 | SH |  | SOLE |  | 4186599 | 0 | 0 |
| CRESCENT BIOPHARMA INC. | COM | G2545C104 |  | 6849365 | 372856 | SH |  | SOLE |  | 372856 | 0 | 0 |
| CRINETICS PHARMACEUTICALS IN | COM | 22663K107 |  | 52712160 | 1451326 | SH |  | SOLE |  | 1451326 | 0 | 0 |
| CULLINAN THERAPEUTICS INC | COM | 230031106 |  | 24241692 | 1705960 | SH |  | SOLE |  | 1705960 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 179351524 | 2721158 | SH |  | SOLE |  | 2721158 | 0 | 0 |
| DEFINIUM THERAPEUTICS INC | COM SHS | 24477V105 |  | 5670000 | 300000 | SH |  | SOLE |  | 300000 | 0 | 0 |
| DIANTHUS THERAPEUTICS INC | COM | 252828108 |  | 20817447 | 248063 | SH |  | SOLE |  | 248063 | 0 | 0 |
| DISC MEDICINE INC | COM | 254604101 |  | 1918200 | 30000 | SH |  | SOLE |  | 30000 | 0 | 0 |
| ERASCA INC | COM | 29479A108 |  | 261423092 | 16157175 | SH |  | SOLE |  | 16157175 | 0 | 0 |
| ESTABLISHMENT LABS HLDGS INC | COM | G31249108 |  | 150790362 | 2655695 | SH |  | SOLE |  | 2655695 | 0 | 0 |
| EVOMMUNE INC | COM SHS | 30054Y107 |  | 34536383 | 1502235 | SH |  | SOLE |  | 1502235 | 0 | 0 |
| EXAGEN INC | COM | 30068X103 |  | 1185693 | 395231 | SH |  | SOLE |  | 395231 | 0 | 0 |
| FULGENT GENETICS INC | COM | 359664109 |  | 20495100 | 1289000 | SH |  | SOLE |  | 1289000 | 0 | 0 |
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 |  | 83429439 | 5933815 | SH |  | SOLE |  | 5933815 | 0 | 0 |
| GUARDANT HEALTH INC | COM | 40131M109 |  | 136803018 | 1481033 | SH |  | SOLE |  | 1481033 | 0 | 0 |
| HEARTFLOW INC | COM | 42238D107 |  | 12043350 | 495000 | SH |  | SOLE |  | 495000 | 0 | 0 |
| HINGE HEALTH INC | CL A | 433313103 |  | 74420800 | 1930000 | SH |  | SOLE |  | 1930000 | 0 | 0 |
| IMAGENEBIO INC | COM | 45175G207 |  | 1672225 | 334445 | SH |  | SOLE |  | 334445 | 0 | 0 |
| IMMATICS N.V | SHS | N44445109 |  | 126634306 | 12869340 | SH |  | SOLE |  | 12869340 | 0 | 0 |
| IMMUNOCORE HLDGS PLC | ADS | 45258D105 |  | 146824410 | 4869798 | SH |  | SOLE |  | 4869798 | 0 | 0 |
| IMMUNOVANT INC | COM | 45258J102 |  | 78937769 | 3177849 | SH |  | SOLE |  | 3177849 | 0 | 0 |
| INSMED INC | COM PAR $.01 | 457669307 |  | 791907738 | 4842880 | SH |  | SOLE |  | 4842880 | 0 | 0 |
| INTUITIVE SURGICAL INC | COM NEW | 46120E602 |  | 101417800 | 220000 | SH |  | SOLE |  | 220000 | 0 | 0 |
| INVENTIVA SA | ADS | 46124U107 |  | 7207796 | 1298702 | SH |  | SOLE |  | 1298702 | 0 | 0 |
| IRHYTHM HOLDINGS INC | COM | 450056106 |  | 196916370 | 1668500 | SH |  | SOLE |  | 1668500 | 0 | 0 |
| JADE BIOSCIENCES INC | COM NEW | 008064206 |  | 8053530 | 573205 | SH |  | SOLE |  | 573205 | 0 | 0 |
| KALARIS THERAPEUTICS INC | COM | 482929106 |  | 7501000 | 1300000 | SH |  | SOLE |  | 1300000 | 0 | 0 |
| KODIAK SCIENCES INC | COM | 50015M109 |  | 56720044 | 1487934 | SH |  | SOLE |  | 1487934 | 0 | 0 |
| KYMERA THERAPEUTICS INC | COM | 501575104 |  | 19989600 | 240000 | SH |  | SOLE |  | 240000 | 0 | 0 |
| LARIMAR THERAPEUTICS INC | COM | 517125100 |  | 6750000 | 1500000 | SH |  | SOLE |  | 1500000 | 0 | 0 |
| LUMEXA IMAGING HOLDINGS INC | COM | 550249106 |  | 5590000 | 650000 | SH |  | SOLE |  | 650000 | 0 | 0 |
| MADRIGAL PHARMACEUTICALS INC | COM | 558868105 |  | 1043635334 | 1993687 | SH |  | SOLE |  | 1993687 | 0 | 0 |
| MEDLINE INC | COM CL A | 58507V107 |  | 3115000 | 70000 | SH |  | SOLE |  | 70000 | 0 | 0 |
| MILESTONE PHARMACEUTICALS IN | COM | 59935V107 |  | 7533891 | 6331001 | SH |  | SOLE |  | 6331001 | 0 | 0 |
| NATERA INC | COM | 632307104 |  | 249987500 | 1250000 | SH |  | SOLE |  | 1250000 | 0 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 |  | 139917365 | 1062072 | SH |  | SOLE |  | 1062072 | 0 | 0 |
| NEUROGENE INC | COM | 64135M105 |  | 27467113 | 1362456 | SH |  | SOLE |  | 1362456 | 0 | 0 |
| OCUGEN INC | COM | 67577C105 |  | 12066665 | 6666666 | SH |  | SOLE |  | 6666666 | 0 | 0 |
| OMADA HEALTH INC | COM | 68170A108 |  | 2514000 | 200000 | SH |  | SOLE |  | 200000 | 0 | 0 |
| ORCHESTRA BIOMED HLDGS INC | COM | 68572M106 |  | 35300768 | 8306063 | SH |  | SOLE |  | 8306063 | 0 | 0 |
| ORUKA THERAPEUTICS INC | COM | 687604108 |  | 100952159 | 2058148 | SH |  | SOLE |  | 2058148 | 0 | 0 |
| PERCEPTIVE CAP SOLUTIONS COR | CL A ORD SHS | G70077105 |  | 8145225 | 742500 | SH |  | SOLE |  | 742500 | 0 | 0 |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 |  | 533224186 | 5059053 | SH |  | SOLE |  | 5059053 | 0 | 0 |
| PTC THERAPEUTICS INC | COM | 69366J200 |  | 527763254 | 7746415 | SH |  | SOLE |  | 7746415 | 0 | 0 |
| RADNET INC | COM | 750491102 |  | 239488650 | 4285000 | SH |  | SOLE |  | 4285000 | 0 | 0 |
| REPLIGEN CORP | COM | 759916109 |  | 142090920 | 1206000 | SH |  | SOLE |  | 1206000 | 0 | 0 |
| REPLIMUNE GROUP INC | COM | 76029N106 |  | 56280407 | 7356916 | SH |  | SOLE |  | 7356916 | 0 | 0 |
| ROCKET PHARMACEUTICALS INC | *W EXP 09/02/202 | 77313F114 |  | 7210 | 350000 | SH |  | SOLE |  | 350000 | 0 | 0 |
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 |  | 63322224 | 17687772 | SH |  | SOLE |  | 17687772 | 0 | 0 |
| SAVARA INC | COM | 805111101 |  | 32499995 | 5952380 | SH |  | SOLE |  | 5952380 | 0 | 0 |
| SPYRE THERAPEUTICS INC | COM NEW | 00773J202 |  | 210435478 | 4171996 | SH |  | SOLE |  | 4171996 | 0 | 0 |
| STOKE THERAPEUTICS INC | COM | 86150R107 |  | 183101974 | 5623525 | SH |  | SOLE |  | 5623525 | 0 | 0 |
| STRYKER CORPORATION | COM | 863667101 |  | 32859000 | 100000 | SH |  | SOLE |  | 100000 | 0 | 0 |
| TANGO THERAPEUTICS INC | COM | 87583X109 |  | 278248970 | 13300620 | SH |  | SOLE |  | 13300620 | 0 | 0 |
| TARSUS PHARMACEUTICALS INC | COM | 87650L103 |  | 234723654 | 3346025 | SH |  | SOLE |  | 3346025 | 0 | 0 |
| TAYSHA GENE THERAPIES INC | COM SHS | 877619106 |  | 61150709 | 13680248 | SH |  | SOLE |  | 13680248 | 0 | 0 |
| TENAX THERAPEUTICS INC | COM NEW | 88032L605 |  | 5920234 | 370246 | SH |  | SOLE |  | 370246 | 0 | 0 |
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 |  | 76442255 | 3648795 | SH |  | SOLE |  | 3648795 | 0 | 0 |
| UNIQURE NV | SHS | N90064101 |  | 42286921 | 2586356 | SH |  | SOLE |  | 2586356 | 0 | 0 |
| UROGEN PHARMA LTD | COM | M96088105 |  | 81699232 | 4543895 | SH |  | SOLE |  | 4543895 | 0 | 0 |
| VERASTEM INC | COM NEW | 92337C203 |  | 34854422 | 6576306 | SH |  | SOLE |  | 6576306 | 0 | 0 |
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 |  | 9787500 | 1350000 | SH |  | SOLE |  | 1350000 | 0 | 0 |
| WAYSTAR HLDG CORP | COM | 946784105 |  | 39299300 | 1630000 | SH |  | SOLE |  | 1630000 | 0 | 0 |
| XENCOR INC | COM | 98401F105 |  | 81736180 | 6777461 | SH |  | SOLE |  | 6777461 | 0 | 0 |
| ZAI LAB LTD | ADR | 98887Q104 |  | 123657542 | 6574032 | SH |  | SOLE |  | 6574032 | 0 | 0 |

---