# EDGAR Filing Document

**Accession Number:** 0001984086
**File Stem:** 0001193125-25-223382
**Filing Date:** 2025-9
**Character Count:** 8857
**Document Hash:** fd0d8b11af2c1dfbc2180ab8e2555a75
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-25-223382.hdr.sgml**: 20250929

**ACCESSION NUMBER**: 0001193125-25-223382

**CONFORMED SUBMISSION TYPE**: 3

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20250925

**FILED AS OF DATE**: 20250929

**DATE AS OF CHANGE**: 20250929

**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Gottesdiener Keith Michael
- **CENTRAL INDEX KEY:** 0001615856

**ORGANIZATION NAME:**

**FILING VALUES:**
- **FORM TYPE:** 3
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-42382
- **FILM NUMBER:** 251357040

**MAIL ADDRESS:**
- **STREET 1:** 900 FIFTH AVENUE
- **STREET 2:** #8C
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10021
**ISSUER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Septerna, Inc.
- **CENTRAL INDEX KEY:** 0001984086
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 843891440
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**BUSINESS ADDRESS:**
- **STREET 1:** 250 EAST GRAND AVENUE, SUITE 65
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080
- **BUSINESS PHONE:** 650-338-3533

**MAIL ADDRESS:**
- **STREET 1:** 250 EAST GRAND AVENUE, SUITE 65
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080

## Ex-24

LIMITED POWER OF ATTORNEY

The undersigned hereby constitutes and appoints each of Jeffrey Finer, Elizabeth

Bhatt, Gil M. Labrucherie and Ran Xiao, signing singly, and with full power of

substitution, the undersigned's true and lawful attorney-in-fact to:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) execute for and on behalf of the undersigned, in the

undersigned's capacity as an officer, director, and/or securityholder of

Septerna, Inc., a Delaware corporation (the "Company"), from time to time the

following U.S. Securities and Exchange Commission ("SEC") forms: (i) Form ID,

including any attached documents (such as Update Passphrase Authentication), to

effect the assignment of codes to the undersigned to be used in the transmission

of information to the SEC using the EDGAR System; (ii) Form 3, Initial Statement

of Beneficial Ownership of Securities, including any attached documents; (iii)

Form 4, Statement of Changes in Beneficial Ownership of Securities, including

any attached documents; (iv) Form 5, Annual Statement of Beneficial Ownership of

Securities in accordance with Section 16(a) of the Securities Exchange Act of

1934, as amended, and the rules thereunder, including any attached documents;

(v) Schedules 13D and 13G; and (vi) amendments of each thereof, in accordance

with the Securities Exchange Act of 1934, as amended, and the rules thereunder,

including any attached documents;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) do and perform any and all acts for and on behalf of the

undersigned which may be necessary or desirable to complete and execute any such

Form 3, 4 or 5, Schedule 13D or 13G, or any amendment(s) thereto and timely file

such form(s) with the SEC and any securities exchange, national association or

similar authority; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3) take any other action of any type whatsoever in connection with

the foregoing which, in the opinion of such attorney-in-fact, may be of benefit

to, in the best interest of, or legally required by, the undersigned, it being

understood that the documents executed by such attorney-in-fact on behalf of the

undersigned pursuant to this Power of Attorney shall be in such form and shall

contain such terms and conditions as such attorney-in-fact may approve in such

attorney-in-factâ€™s discretion.

The undersigned hereby grants to each such attorney-in-fact, acting

singly, full power and authority to do and perform any and every act and thing

whatsoever requisite, necessary or proper to be done in the exercise of any of

the rights and powers herein granted, as fully to all intents and purposes as

the undersigned might or could do if personally present, with full power of

substitution or revocation, hereby ratifying and confirming all that such

attorney-in-fact, or such attorney-in-factâ€™s substitute or substitutes, shall

lawfully do or cause to be done by virtue of this power of attorney and the

rights and powers herein granted. The undersigned acknowledges that the

foregoing attorneys-in-fact, in serving in such capacity at the request of the

undersigned, are not assuming, nor is the Company assuming, any of the

undersignedâ€™s responsibilities to comply with Section 16 or Regulation 13D-G of

the Securities Exchange Act of 1934, as amended. The undersigned hereby agrees

to indemnify the attorneys-in-fact and the Company from and against any demand,

damage, loss, cost or expense arising from any false or misleading information

provided by the undersigned to the attorneys-in-fact.

This Power of Attorney shall remain in full force and effect until the

undersigned is no longer required to file such forms with respect to the

undersignedâ€™s holdings of and transactions in securities issued by the Company,

unless earlier revoked by the undersigned in a signed writing delivered to the

foregoing attorneys-in-fact. This Power of Attorney supersedes any prior power

of attorney in connection with the undersigned's capacity as an officer and/or

director of the Company. This Power of Attorney shall expire as to any

individual attorney-in-fact if such attorney-in-fact ceases to be an employee of

the Company.

------

IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to

be executed as of September 25, 2025.

/s/ Keith Gottesdiener

Signature

Keith Gottesdiener

Print Name

------

### UNITED STATES SECURITIES AND EXCHANGE COMMISSION
**Washington, D.C. 20549**

## FORM 3

### INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Gottesdiener Keith Michael<br><sub>(Last) (First) (Middle)</sub><br>C/O SEPTERNA, INC.<br>250 EAST GRAND AVENUE<br><sub>(Street)</sub><br>SOUTH SAN FRANCISCO, CA 94080<br><sub>(City) (State) (Zip)</sub> | **3. Issuer Name and Ticker or Trading Symbol**<br>Septerna, Inc. [ SEPN ] | **5. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  |
| **2. Date of Event Requiring Statement (Month/Day/Year)**<br>2025-09-25 | **4. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[X] Director   [ ] 10% Owner<br>[ ] Officer (give title below)   [ ] Other (specify below)<br>_ _ | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[X] Form filed by One Reporting Person<br>[ ] Form filed by More than One Reporting Person |

---

## Table I - Non-Derivative Securities Beneficially Owned

---

|  |  |  |  |
| --- | --- | --- | --- |
| 1. Title of Security | 2. Amount of Securities Beneficially Owned | 3. Ownership Form | 4. Nature of Indirect Beneficial Ownership |

---

## Table II - Derivative Securities Beneficially Owned

---

|  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- |
| 1. Title of Derivative Security | 2. Date Exercisable and Expiration Date (Month/Day/Year) | 2. Date Exercisable and Expiration Date (Month/Day/Year) | 3. Title and Amount of Underlying Securities | 3. Title and Amount of Underlying Securities | 4. Conversion or Exercise Price | 5. Ownership Form | 6. Nature of Indirect Beneficial Ownership |
| 1. Title of Derivative Security | Date Exercisable | Expiration Date | Title | Amount or Number of Shares | 4. Conversion or Exercise Price | 5. Ownership Form | 6. Nature of Indirect Beneficial Ownership |
|  |  |  |  |  |  |  |  |

---

**Remarks:**
Exhibit 24 - Power of Attorney

**Signature:** /s/ Gil M. Labrucherie, Attorney-in-Fact  
**Date:** 2025-09-29

### Remarks:

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

**Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.**