# EDGAR Filing Document

**Accession Number:** 0001715578
**File Stem:** 0001193125-26-281115
**Filing Date:** 2026-6
**Character Count:** 27709
**Document Hash:** 669c4074df18fa1122bd94afb7cdad09
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-26-281115.hdr.sgml**: 20260624

**ACCESSION NUMBER**: 0001193125-26-281115

**CONFORMED SUBMISSION TYPE**: 4

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20260624

**FILED AS OF DATE**: 20260624

**DATE AS OF CHANGE**: 20260624

**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Medicxi Growth I LP
- **CENTRAL INDEX KEY:** 0001690310

**ORGANIZATION NAME:**
- **STATE OF INCORPORATION:** Y9

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-40445
- **FILM NUMBER:** 261116194

**BUSINESS ADDRESS:**
- **STREET 1:** C/O ELIAN FUND SERVICES (JERSEY) LIMITED
- **STREET 2:** 44 ESPLANADE
- **CITY:** ST HELIER
- **STATE:** Y9
- **ZIP:** JE4 9WG
- **BUSINESS PHONE:** 44 (0)1534 504343

**MAIL ADDRESS:**
- **STREET 1:** C/O ELIAN FUND SERVICES (JERSEY) LIMITED
- **STREET 2:** 44 ESPLANADE
- **CITY:** ST HELIER
- **STATE:** Y9
- **ZIP:** JE4 9WG
**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Medicxi Growth Co-Invest I LP
- **CENTRAL INDEX KEY:** 0001715578

**ORGANIZATION NAME:**

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-40445
- **FILM NUMBER:** 261116193

**BUSINESS ADDRESS:**
- **STREET 1:** C/O INTERTRUST FUND SERVICES (JERSEY)
- **STREET 2:** 44 ESPLANADE
- **CITY:** ST. HELIER
- **STATE:** Y9
- **ZIP:** JE4 9WG
- **BUSINESS PHONE:** 44 (0) 1534 504343

**MAIL ADDRESS:**
- **STREET 1:** C/O INTERTRUST FUND SERVICES (JERSEY)
- **STREET 2:** 44 ESPLANADE
- **CITY:** ST. HELIER
- **STATE:** Y9
- **ZIP:** JE4 9WG
**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Medicxi Ventures Management (Jersey) Ltd
- **CENTRAL INDEX KEY:** 0001715579

**ORGANIZATION NAME:**
- **STATE OF INCORPORATION:** Y9

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-40445
- **FILM NUMBER:** 261116198

**BUSINESS ADDRESS:**
- **STREET 1:** C/O CSC FUND SERVICES (JERSEY) LIMITED
- **STREET 2:** 44 ESPLANADE
- **CITY:** ST. HELIER
- **STATE:** Y9
- **ZIP:** JE4 9WG
- **BUSINESS PHONE:** 44 (0) 1534 504343

**MAIL ADDRESS:**
- **STREET 1:** C/O CSC FUND SERVICES (JERSEY) LIMITED
- **STREET 2:** 44 ESPLANADE
- **CITY:** ST. HELIER
- **STATE:** Y9
- **ZIP:** JE4 9WG
**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Medicxi Growth I GP Ltd
- **CENTRAL INDEX KEY:** 0001715600

**ORGANIZATION NAME:**

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-40445
- **FILM NUMBER:** 261116192

**BUSINESS ADDRESS:**
- **STREET 1:** C/O INTERTRUST FUND SERVICES (JERSEY)
- **STREET 2:** 44 ESPLANADE
- **CITY:** ST. HELIER
- **STATE:** Y9
- **ZIP:** JE4 9WG
- **BUSINESS PHONE:** 44 (0) 1534 504343

**MAIL ADDRESS:**
- **STREET 1:** C/O INTERTRUST FUND SERVICES (JERSEY)
- **STREET 2:** 44 ESPLANADE
- **CITY:** ST. HELIER
- **STATE:** Y9
- **ZIP:** JE4 9WG
**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Medicxi Ventures I GP Ltd
- **CENTRAL INDEX KEY:** 0001760411

**ORGANIZATION NAME:**
- **STATE OF INCORPORATION:** Y9
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-40445
- **FILM NUMBER:** 261116195

**BUSINESS ADDRESS:**
- **STREET 1:** 44 ESPLANADE
- **CITY:** ST HELIER
- **STATE:** Y9
- **ZIP:** JE4 9WG
- **BUSINESS PHONE:** 4401534481050

**MAIL ADDRESS:**
- **STREET 1:** 44 ESPLANADE
- **CITY:** ST HELIER
- **STATE:** Y9
- **ZIP:** JE4 9WG
**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Medicxi Secondary Co-Invest I LP
- **CENTRAL INDEX KEY:** 0001865493

**ORGANIZATION NAME:**
- **STATE OF INCORPORATION:** Y9
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-40445
- **FILM NUMBER:** 261116190

**BUSINESS ADDRESS:**
- **STREET 1:** INTERTRUST FUND SERVICES (JERSEY)
- **STREET 2:** 44 ESPLANADE
- **CITY:** ST HELIER
- **STATE:** Y9
- **ZIP:** JE4 9WG
- **BUSINESS PHONE:** 44-0-1534-504343

**MAIL ADDRESS:**
- **STREET 1:** INTERTRUST FUND SERVICES (JERSEY)
- **STREET 2:** 44 ESPLANADE
- **CITY:** ST HELIER
- **STATE:** Y9
- **ZIP:** JE4 9WG
**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Medicxi Co-Invest I LP
- **CENTRAL INDEX KEY:** 0001760413

**ORGANIZATION NAME:**
- **STATE OF INCORPORATION:** Y9
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-40445
- **FILM NUMBER:** 261116196

**BUSINESS ADDRESS:**
- **STREET 1:** 44 ESPLANADE
- **CITY:** ST HELIER
- **STATE:** Y9
- **ZIP:** JE4 9WG
- **BUSINESS PHONE:** 4401534481050

**MAIL ADDRESS:**
- **STREET 1:** 44 ESPLANADE
- **CITY:** ST HELIER
- **STATE:** Y9
- **ZIP:** JE4 9WG
**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Medicxi Secondary I LP
- **CENTRAL INDEX KEY:** 0001824997

**ORGANIZATION NAME:**
- **STATE OF INCORPORATION:** Y9

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-40445
- **FILM NUMBER:** 261116191

**BUSINESS ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** C/O INTERTRUST FUND SERVICES (JERSEY)
- **STREET 2:** 44 ESPLANADE
- **CITY:** ST HELIER
- **PROVINCE COUNTRY:** Y9
- **BUSINESS PHONE:** 44-0-1534-504343

**MAIL ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** C/O INTERTRUST FUND SERVICES (JERSEY)
- **STREET 2:** 44 ESPLANADE
- **CITY:** ST HELIER
- **PROVINCE COUNTRY:** Y9
**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Medicxi Ventures I LP
- **CENTRAL INDEX KEY:** 0001760412

**ORGANIZATION NAME:**
- **STATE OF INCORPORATION:** Y9
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-40445
- **FILM NUMBER:** 261116197

**BUSINESS ADDRESS:**
- **STREET 1:** 44 ESPLANADE
- **CITY:** ST HELIER
- **STATE:** Y9
- **ZIP:** JE4 9WG
- **BUSINESS PHONE:** 4401534481050

**MAIL ADDRESS:**
- **STREET 1:** 44 ESPLANADE
- **CITY:** ST HELIER
- **STATE:** Y9
- **ZIP:** JE4 9WG
**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Medicxi Secondary I GP Ltd.
- **CENTRAL INDEX KEY:** 0001865487

**ORGANIZATION NAME:**
- **STATE OF INCORPORATION:** Y9
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-40445
- **FILM NUMBER:** 261116189

**BUSINESS ADDRESS:**
- **STREET 1:** INTERTRUST FUND SERVICES (JERSEY)
- **STREET 2:** 44 ESPLANADE
- **CITY:** ST HELIER
- **STATE:** Y9
- **ZIP:** JE4 9WG
- **BUSINESS PHONE:** 44-0-1534-504343

**MAIL ADDRESS:**
- **STREET 1:** INTERTRUST FUND SERVICES (JERSEY)
- **STREET 2:** 44 ESPLANADE
- **CITY:** ST HELIER
- **STATE:** Y9
- **ZIP:** JE4 9WG
**ISSUER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Centessa Pharmaceuticals plc
- **CENTRAL INDEX KEY:** 0001847903
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** X0
- **FISCAL YEAR END:** 1231

**BUSINESS ADDRESS:**
- **STREET 1:** 3RD FLOOR
- **STREET 2:** 1 ASHLEY ROAD
- **CITY:** ALTRINCHAM, CHESHIRE
- **STATE:** X0
- **ZIP:** WA14 2DT
- **BUSINESS PHONE:** 44 7391 789784

**MAIL ADDRESS:**
- **STREET 1:** 3RD FLOOR
- **STREET 2:** 1 ASHLEY ROAD
- **CITY:** ALTRINCHAM, CHESHIRE
- **STATE:** X0
- **ZIP:** WA14 2DT

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Centessa Pharmaceuticals Ltd
- **DATE OF NAME CHANGE:** 20210224

### UNITED STATES SECURITIES AND EXCHANGE COMMISSION
**Washington, D.C. 20549**

## FORM 4

### STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

[x] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

[ ] Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Medicxi Ventures Management (Jersey) Ltd<br><sub>(Last) (First) (Middle)</sub><br>C/O CSC FUND SERVICES (JERSEY)<br>44 ESPLANADE<br><sub>(Street)</sub><br>ST. HELIER, JERSEY JE4 9WG<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2026-06-24 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[ ] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>Centessa Pharmaceuticals plc [ CNTA ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Medicxi Ventures I LP<br><sub>(Last) (First) (Middle)</sub><br>C/O CSC FUND SERVICES (JERSEY)<br>44 ESPLANADE<br><sub>(Street)</sub><br>ST. HELIER, JERSEY JE4 9WG<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2026-06-24 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[ ] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>Centessa Pharmaceuticals plc [ CNTA ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Medicxi Co-Invest I LP<br><sub>(Last) (First) (Middle)</sub><br>C/O CSC FUND SERVICES (JERSEY)<br>44 ESPLANADE<br><sub>(Street)</sub><br>ST. HELIER, JERSEY JE4 9WG<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2026-06-24 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[ ] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>Centessa Pharmaceuticals plc [ CNTA ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Medicxi Ventures I GP Ltd<br><sub>(Last) (First) (Middle)</sub><br>C/O CSC FUND SERVICES (JERSEY)<br>44 ESPLANADE<br><sub>(Street)</sub><br>ST. HELIER, JERSEY JE4 9WG<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2026-06-24 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[ ] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>Centessa Pharmaceuticals plc [ CNTA ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Medicxi Growth I LP<br><sub>(Last) (First) (Middle)</sub><br>C/O CSC FUND SERVICES (JERSEY)<br>44 ESPLANADE<br><sub>(Street)</sub><br>ST. HELIER, JERSEY JE4 9WG<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2026-06-24 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[ ] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>Centessa Pharmaceuticals plc [ CNTA ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Medicxi Growth Co-Invest I LP<br><sub>(Last) (First) (Middle)</sub><br>C/O CSC FUND SERVICES (JERSEY)<br>44 ESPLANADE<br><sub>(Street)</sub><br>ST. HELIER, JERSEY JE4 9WG<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2026-06-24 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[ ] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>Centessa Pharmaceuticals plc [ CNTA ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Medicxi Growth I GP Ltd<br><sub>(Last) (First) (Middle)</sub><br>C/O CSC FUND SERVICES (JERSEY)<br>44 ESPLANADE<br><sub>(Street)</sub><br>ST. HELIER, JERSEY JE4 9WG<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2026-06-24 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[ ] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>Centessa Pharmaceuticals plc [ CNTA ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Medicxi Secondary I LP<br><sub>(Last) (First) (Middle)</sub><br>C/O CSC FUND SERVICES (JERSEY)<br>44 ESPLANADE<br><sub>(Street)</sub><br>ST. HELIER, JERSEY JE4 9WG<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2026-06-24 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[ ] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>Centessa Pharmaceuticals plc [ CNTA ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Medicxi Secondary Co-Invest I LP<br><sub>(Last) (First) (Middle)</sub><br>C/O CSC FUND SERVICES (JERSEY)<br>44 ESPLANADE<br><sub>(Street)</sub><br>ST. HELIER, JERSEY JE4 9WG<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2026-06-24 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[ ] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>Centessa Pharmaceuticals plc [ CNTA ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Medicxi Secondary I GP Ltd.<br><sub>(Last) (First) (Middle)</sub><br>C/O CSC FUND SERVICES (JERSEY)<br>44 ESPLANADE<br><sub>(Street)</sub><br>ST. HELIER, JERSEY JE4 9WG<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2026-06-24 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[ ] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>Centessa Pharmaceuticals plc [ CNTA ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

## Table I - Non-Derivative Securities

---

|  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1. Title of Security | 2. Transaction Date | 2A. Deemed Execution Date | 3. Transaction Code (V) | 3. Transaction Code (V) | 4. Securities Acquired (A) or Disposed of (D) | 4. Securities Acquired (A) or Disposed of (D) | 4. Securities Acquired (A) or Disposed of (D) | 5. Amount of Securities Beneficially Owned | 6. Ownership Form | 7. Nature of Indirect Beneficial Ownership |
| 1. Title of Security | 2. Transaction Date | 2A. Deemed Execution Date | Code | V | Amount | (A) or (D) | Price | 5. Amount of Securities Beneficially Owned | 6. Ownership Form | 7. Nature of Indirect Beneficial Ownership |
| Ordinary Shares<sup>(1)</sup> | 2026-06-24 |  | S<sup>(2)(3)(4)</sup> |  | 4398519 | D | <sup>(3)(4)</sup> | 0 | I | See footnote<sup>(5)</sup> |
| Ordinary Shares<sup>(1)</sup> | 2026-06-24 |  | S<sup>(2)(3)(4)</sup> |  | 55677 | D | <sup>(3)(4)</sup> | 0 | I | See footnote<sup>(6)</sup> |
| Ordinary Shares<sup>(1)</sup> | 2026-06-24 |  | S<sup>(2)(3)(4)</sup> |  | 3936970 | D | <sup>(3)(4)</sup> | 0 | I | See footnote<sup>(7)</sup> |
| Ordinary Shares<sup>(1)</sup> | 2026-06-24 |  | S<sup>(2)(3)(4)</sup> |  | 93526 | D | <sup>(3)(4)</sup> | 0 | I | See footnote<sup>(8)</sup> |
| Ordinary Shares<sup>(1)</sup> | 2026-06-24 |  | S<sup>(2)(3)(4)</sup> |  | 11197303 | D | <sup>(3)(4)</sup> | 0 | I | See footnote<sup>(9)</sup> |
| Ordinary Shares<sup>(1)</sup> | 2026-06-24 |  | S<sup>(2)(3)(4)</sup> |  | 281162 | D | <sup>(3)(4)</sup> | 0 | I | See footnote<sup>(10)</sup> |

---

## Table II - Derivative Securities

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1. Title of Derivative Security | 2. Conversion or Exercise Price | 3. Transaction Date | 3A. Deemed Execution Date | 4. Transaction Code (V) | 4. Transaction Code (V) | 5. Number of Derivative Securities Acquired (A) or Disposed of (D) | 5. Number of Derivative Securities Acquired (A) or Disposed of (D) | 6. Date Exercisable and Expiration Date | 6. Date Exercisable and Expiration Date | 7. Title and Amount of Underlying Securities | 7. Title and Amount of Underlying Securities | 8. Price of Derivative Security | 9. Number of Derivative Securities Beneficially Owned | 10. Ownership Form | 11. Nature of Indirect Beneficial Ownership |
| 1. Title of Derivative Security | 2. Conversion or Exercise Price | 3. Transaction Date | 3A. Deemed Execution Date | Code | V | (A) | (D) | Date Exercisable | Expiration Date | Title | Amount or Number of Shares | 8. Price of Derivative Security | 9. Number of Derivative Securities Beneficially Owned | 10. Ownership Form | 11. Nature of Indirect Beneficial Ownership |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

---

### Footnotes:

(1) The Ordinary Shares may be represented by American Depositary Shares ("ADSs"), each of which currently represents one Ordinary Share.

(2) On June 24, 2026, Eli Lilly and Company ("Parent"), through its wholly owned subsidiary LDH XV Corporation ("Purchaser"), acquired all outstanding Ordinary Shares of Centessa Pharmaceuticals plc (the "Company") by means of a scheme of arrangement under Part 26 of the UK Companies Act 2006 (the "Scheme of Arrangement"), pursuant to the Transaction Agreement dated as of March 31, 2026, by and among the Company, Parent and Purchaser (the "Transaction Agreement").

(3) At the effective time of the Scheme of Arrangement (the "Effective Time"), holders of Ordinary Shares became entitled to receive (a) $38.00 in cash per Ordinary Share (the "Cash Consideration"), without interest and less any applicable withholding taxes, and (b) one non-transferable contingent value right (a "CVR") entitling the holders to receive contingent payments of up to an aggregate of $9.00 per Ordinary Share, without interest and less any applicable withholding taxes, contingent upon the achievement of specified milestones set forth in the Contingent Value Rights Agreement between Parent, Purchaser and a rights agent mutually agreeable to the Company and Parent. Because each ADS represents one Ordinary Share, holders of ADSs became entitled to the same per-share consideration of $38.00 in cash plus one CVR per ADS.

(4) (continued from footnote 3) The transfer of Ordinary Shares occurred automatically at the Effective Time pursuant to the Scheme of Arrangement, without any action by or discretion of the Reporting Persons.

(5) Held by Medicxi Ventures I LP, a Jersey limited partnership ("Medicxi Ventures I"). Medicxi Ventures I GP Limited, a Jersey limited liability company ("MVI GP"), is the sole managing general partner of Medicxi Ventures I, and Medicxi Ventures Management (Jersey) Limited, a Jersey limited liability company ("Medicxi Manager"), is the sole manager of Medicxi Ventures I. The Reporting Persons disclaim Section 16 beneficial ownership of the securities held by Medicxi Ventures I, except to the extent of their respective pecuniary interest therein, if any, and this report shall not be deemed to be an admission that they have beneficial ownership of such shares for Section 16 or any other purpose.

(6) Held by Medicxi Co-Invest I LP, a Jersey limited partnership ("Medicxi Co-Invest I"). MVI GP is the sole managing general partner of Medicxi Co-Invest I, and Medicxi Manager is the sole manager of Medicxi Co-Invest I. The Reporting Persons disclaim Section 16 beneficial ownership of the securities held by Medicxi Co-Invest I, except to the extent of their respective pecuniary interest therein, if any, and this report shall not be deemed to be an admission that they have beneficial ownership of such shares for Section 16 or any other purpose.

(7) Held by Medicxi Growth I LP, a Jersey limited partnership ("Medicxi Growth I"). Medicxi Growth I GP Limited, a Jersey limited liability company ("MGI GP"), is the sole managing general partner of Medicxi Growth I, and Medicxi Manager is the sole manager of Medicxi Growth I. The Reporting Persons disclaim Section 16 beneficial ownership of the securities held by Medicxi Growth I, except to the extent of their respective pecuniary interest therein, if any, and this report shall not be deemed to be an admission that they have beneficial ownership of such shares for Section 16 or any other purpose.

(8) Held by Medicxi Growth Co-Invest I LP, a Jersey limited partnership ("Medicxi Growth Co-Invest I"). MGI GP is the sole managing general partner of Medicxi Growth Co-Invest I, and Medicxi Manager is the sole manager of Medicxi Growth Co-Invest I. The Reporting Persons disclaim Section 16 beneficial ownership of the securities held by Medicxi Growth Co-Invest I, except to the extent of their respective pecuniary interest therein, if any, and this report shall not be deemed to be an admission that they have beneficial ownership of such shares for Section 16 or any other purpose.

(9) Held by Medicxi Secondary I LP, a Jersey limited partnership ("Medicxi Secondary I"). Medicxi Secondary I GP Limited, a Jersey limited liability company ("MSI GP"), is the sole managing general partner of Medicxi Secondary I, and Medicxi Manager is the sole manager of Medicxi Secondary I. The Reporting Persons disclaim Section 16 beneficial ownership of the securities held by Medicxi Secondary I, except to the extent of their respective pecuniary interest therein, if any, and this report shall not be deemed to be an admission that they have beneficial ownership of such shares for Section 16 or any other purpose.

(10) Held by Medicxi Secondary Co-Invest I LP, a Jersey limited partnership ("Medicxi Secondary Co-Invest I"). MSI GP is the sole managing general partner of Medicxi Secondary Co-Invest I, and Medicxi Manager is the sole manager of Medicxi Secondary Co-Invest I. The Reporting Persons disclaim Section 16 beneficial ownership of the securities held by Medicxi Secondary Co-Invest I, except to the extent of their respective pecuniary interest therein, if any, and this report shall not be deemed to be an admission that they have beneficial ownership of such shares for Section 16 or any other purpose.

**Remarks:**
Medicxi Ventures (UK) LLP and Medicxi Ventures (Jersey) Limited act as sub-advisers to Index Ventures Life VI (Jersey) Limited, which acts as the adviser to Index Ventures Life VI (Jersey) LP, and as such, Index Ventures Life VI and Yucca (Jersey) SLP, each of which held Ordinary Shares prior to the transactions reported herein, and the Medicxi Funds may be deemed to be members of a "group" as defined in Rule 13d-5 of the Securities Exchange Act of 1934, as amended.

**Signature:** Medicxi Ventures Management (Jersey) Limited, By: /s/ Francois Chesnay, Its: Director  
**Date:** 2026-06-24

**Signature:** Medicxi Ventures I LP, By: Medicxi Ventures Management (Jersey) Limited, By: /s/ Francois Chesnay, Its: Director  
**Date:** 2026-06-24

**Signature:** Medicxi Co-Invest I LP, By: Medicxi Ventures Management (Jersey) Limited, By: /s/ Francois Chesnay, Its: Director  
**Date:** 2026-06-24

**Signature:** Medicxi Ventures I GP Limited, By: /s/ Francois Chesnay, Its: Director  
**Date:** 2026-06-24

**Signature:** Medicxi Growth I LP, By: Medicxi Ventures Management (Jersey) Limited, By: /s/ Francois Chesnay, Its: Director  
**Date:** 2026-06-24

**Signature:** Medicxi Growth Co-Invest I LP, By: Medicxi Ventures Management (Jersey) Limited, By: /s/ Francois Chesnay, Its: Director  
**Date:** 2026-06-24

**Signature:** Medicxi Growth I GP Ltd, By: /s/ Francois Chesnay, Its: Director  
**Date:** 2026-06-24

**Signature:** Medicxi Secondary I LP, By: Medicxi Ventures Management (Jersey) Limited, By: /s/ Francois Chesnay, Its: Director  
**Date:** 2026-06-24

**Signature:** Medicxi Secondary Co-Invest I LP, By: Medicxi Ventures Management (Jersey) Limited, By: /s/ Francois Chesnay, Its: Director  
**Date:** 2026-06-24

**Signature:** Medicxi Secondary I GP Limited, By: /s/ Francois Chesnay, Its: Director  
**Date:** 2026-06-24

### Remarks:

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