# EDGAR Filing Document

**Accession Number:** 0001100663
**File Stem:** 0002071691-26-004248
**Filing Date:** 2026-2
**Character Count:** 96612
**Document Hash:** bae97f3bbd55e1a131a4b762638b7858
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0002071691-26-004248.hdr.sgml**: 20260225

**ACCESSION NUMBER**: 0002071691-26-004248

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20251231

**FILED AS OF DATE**: 20260225

**DATE AS OF CHANGE**: 20260225

**PERIOD START**: 20260331

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** iSHARES TRUST
- **CENTRAL INDEX KEY:** 0001100663

**ORGANIZATION NAME:**
- **EIN:** 943351276
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-09729
- **FILM NUMBER:** 26675635

**BUSINESS ADDRESS:**
- **STREET 1:** 400 HOWARD STREET
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94105
- **BUSINESS PHONE:** (415) 670-2000

**MAIL ADDRESS:**
- **STREET 1:** 400 HOWARD STREET
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94105

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ISHARES TRUST
- **DATE OF NAME CHANGE:** 19991213

## Series and Classes Contracts Data

### iShares Biotechnology ETF (Series ID: S000004350)

| Class ID   | Class Name                | Ticker Symbol   |
|:---|:---|:---|
| C000012080 | iShares Biotechnology ETF | IBB             |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** iShares Trust

- **b. Investment Company Act file number:** 811-09729

- **c. CIK number of Registrant:** 0001100663

- **d. LEI of Registrant:** 5493000860OXIC4B5K91

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 400 Howard Street

  - **City:** San Francisco

  - **State:** CA

  - **Foreign country:** US

  - **Zip / Postal Code:** 94105

  - **Telephone number:** 800-474-2737

**Item A.2. Information about the Series.**

- **a. Name of Series:** iShares Biotechnology ETF

- **b. EDGAR series identifier (if any):** S000004350

- **c. LEI of Series:** 549300S7IVD88MPK0066

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2026-03-31

- **b. Date as of which information is reported:** 2025-12-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $9152085144.29

**Total Liabilities:** $813661398.63

**Net Assets:** $8338423745.66

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000012080 | 10.44%               | 8.92%                | -2.70%               |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $159852559.17            | $468460594.87                              |
| Month 2  | $200531913.97            | $460671617.55                              |
| Month 3  | $163597725.12            | $-403669440.73                             |

**Designated Index Information**

- **Index Name:** N/A

- **Index Identifier:** N/A

### Schedule of Portfolio Investments

| Name                                           | Title                                                 | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| ADMA Biologics, Inc.                           | ADMA Biologics, Inc.                                  | CUSIP: 000899104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1692130 | NS      | $30864451.20  | 0.37%             |  |  |  | No            |                  1 | On Loan: —       |
| Absci Corp.                                    | Absci Corp.                                           | CUSIP: 00091E109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1001452 | NS      | $3495067.48   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| AbCellera Biologics, Inc.                      | AbCellera Biologics, Inc.                             | CUSIP: 00288U106<br>LEI: 9845000861BC95FF9F73 | Long             | EC               | CORP              | CA        |   1701738 | NS      | $5819943.96   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Aardvark Therapeutics, Inc.                    | Aardvark Therapeutics, Inc.                           | CUSIP: 002942100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     92100 | NS      | $1208812.50   | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Abivax SA                                      | Abivax SA                                             | CUSIP: 00370M103<br>LEI: 969500D8TMNB184OJU95 | Long             | EC               | CORP              | FR        |    388923 | NS      | $52448211.17  | 0.63%             |  |  |  | No            |                  1 | On Loan: —       |
| ACADIA Pharmaceuticals, Inc.                   | ACADIA Pharmaceuticals, Inc.                          | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |   1231029 | NS      | $32880784.59  | 0.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Aclaris Therapeutics, Inc.                     | Aclaris Therapeutics, Inc.                            | CUSIP: 00461U105<br>LEI: 5493000B2LQ9QTW1DF52 | Long             | EC               | CORP              | US        |    682633 | NS      | $2054725.33   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Adaptive Biotechnologies Corp.                 | Adaptive Biotechnologies Corp.                        | CUSIP: 00650F109<br>LEI: 549300ZTF7OT1FW66Q96 | Long             | EC               | CORP              | US        |   1080962 | NS      | $17554822.88  | 0.21%             |  |  |  | No            |                  1 | On Loan: —       |
| Spyre Therapeutics, Inc.                       | Spyre Therapeutics, Inc.                              | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |    498015 | NS      | $16314971.40  | 0.20%             |  |  |  | No            |                  1 | On Loan: —       |
| Agios Pharmaceuticals, Inc.                    | Agios Pharmaceuticals, Inc.                           | CUSIP: 00847X104<br>LEI: 529900ONJHY8EOGYT555 | Long             | EC               | CORP              | US        |    405379 | NS      | $11034416.38  | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Akouos, Inc.                                   | Akouos, Inc., CVR                                     | CUSIP: 009CVR036<br>LEI: N/A                  | Long             |  | CORP              | US        |    157087 | NS      | $1.57         | 0.00%             |  |  |  | No            |                  3 | On Loan: —       |
| Akero Therapeutics, Inc.                       | Akero Therapeutics, Inc., CVR                         | CUSIP: 009CVR044<br>LEI: 549300SI3KG74LBE2955 | Long             |  | CORP              | US        |    515954 | NS      | $335370.10    | 0.00%             |  |  |  | No            |                  3 | On Loan: —       |
| Allogene Therapeutics, Inc.                    | Allogene Therapeutics, Inc.                           | CUSIP: 019770106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1176538 | NS      | $1611857.06   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Alnylam Pharmaceuticals, Inc.                  | Alnylam Pharmaceuticals, Inc.                         | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |    956525 | NS      | $380362166.25 | 4.56%             |  |  |  | No            |                  1 | On Loan: —       |
| Alpha Teknova, Inc.                            | Alpha Teknova, Inc.                                   | CUSIP: 02080L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     81794 | NS      | $310817.20    | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| Altimmune, Inc.                                | Altimmune, Inc.                                       | CUSIP: 02155H200<br>LEI: 549300EOYCQ8SW3NVE64 | Long             | EC               | CORP              | US        |    763762 | NS      | $2757180.82   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Alto Neuroscience, Inc.                        | Alto Neuroscience, Inc.                               | CUSIP: 02157Q109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    202030 | NS      | $3596134.00   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Alumis, Inc.                                   | Alumis, Inc.                                          | CUSIP: 022307102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    452318 | NS      | $4414623.68   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Amgen, Inc.                                    | Amgen, Inc.                                           | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |   1997731 | NS      | $653877333.61 | 7.84%             |  |  |  | No            |                  1 | On Loan: No      |
| Amicus Therapeutics, Inc.                      | Amicus Therapeutics, Inc.                             | CUSIP: 03152W109<br>LEI: 549300MRD1SMUTNBPQ53 | Long             | EC               | CORP              | US        |   2223625 | NS      | $31664420.00  | 0.38%             |  |  |  | No            |                  1 | On Loan: No      |
| Amylyx Pharmaceuticals, Inc.                   | Amylyx Pharmaceuticals, Inc.                          | CUSIP: 03237H101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    671938 | NS      | $8117011.04   | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| AnaptysBio, Inc.                               | AnaptysBio, Inc.                                      | CUSIP: 032724106<br>LEI: 529900HH4WQT03IG1A12 | Long             | EC               | CORP              | US        |    192175 | NS      | $9316644.00   | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| Anavex Life Sciences Corp.                     | Anavex Life Sciences Corp.                            | CUSIP: 032797300<br>LEI: 549300K1I5L8COCQ8W36 | Long             | EC               | CORP              | US        |    637146 | NS      | $2268239.76   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Annexon, Inc.                                  | Annexon, Inc.                                         | CUSIP: 03589W102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    907392 | NS      | $4555107.84   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Apellis Pharmaceuticals, Inc.                  | Apellis Pharmaceuticals, Inc.                         | CUSIP: 03753U106<br>LEI: 254900HS0ZFRXXSB9D42 | Long             | EC               | CORP              | US        |    765654 | NS      | $19233228.48  | 0.23%             |  |  |  | No            |                  1 | On Loan: —       |
| Apogee Therapeutics, Inc.                      | Apogee Therapeutics, Inc.                             | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    350484 | NS      | $26454532.32  | 0.32%             |  |  |  | No            |                  1 | On Loan: —       |
| Arbutus Biopharma Corp.                        | Arbutus Biopharma Corp.                               | CUSIP: 03879J100<br>LEI: 25490064CESONAUIAS23 | Long             | EC               | CORP              | CA        |   1108398 | NS      | $5331394.38   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Arcellx, Inc.                                  | Arcellx, Inc.                                         | CUSIP: 03940C100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    319085 | NS      | $20804342.00  | 0.25%             |  |  |  | No            |                  1 | On Loan: —       |
| Arcus Biosciences, Inc.                        | Arcus Biosciences, Inc.                               | CUSIP: 03969F109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    552793 | NS      | $13173057.19  | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcutis Biotherapeutics, Inc.                  | Arcutis Biotherapeutics, Inc.                         | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    794139 | NS      | $23061796.56  | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcturus Therapeutics Holdings, Inc.           | Arcturus Therapeutics Holdings, Inc.                  | CUSIP: 03969T109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    192011 | NS      | $1177027.43   | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Argenx SE                                      | Argenx SE                                             | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |    298350 | NS      | $250897432.50 | 3.01%             |  |  |  | No            |                  1 | On Loan: No      |
| ArriVent Biopharma, Inc.                       | ArriVent Biopharma, Inc.                              | CUSIP: 04272N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    192116 | NS      | $3865373.92   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Arrowhead Pharmaceuticals, Inc.                | Arrowhead Pharmaceuticals, Inc.                       | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |    928359 | NS      | $61633754.01  | 0.74%             |  |  |  | No            |                  1 | On Loan: No      |
| Arvinas, Inc.                                  | Arvinas, Inc.                                         | CUSIP: 04335A105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    407959 | NS      | $4838393.74   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Ascendis Pharma A/S                            | Ascendis Pharma A/S                                   | CUSIP: 04351P101<br>LEI: 549300B66JN3W3J8GH73 | Long             | EC               | CORP              | DK        |    341419 | NS      | $72804187.56  | 0.87%             |  |  |  | No            |                  1 | On Loan: —       |
| Astria Therapeutics, Inc.                      | Astria Therapeutics, Inc.                             | CUSIP: 04635X102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    368644 | NS      | $4825549.96   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Atea Pharmaceuticals, Inc.                     | Atea Pharmaceuticals, Inc.                            | CUSIP: 04683R106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    455201 | NS      | $1625067.57   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Aura Biosciences, Inc.                         | Aura Biosciences, Inc.                                | CUSIP: 05153U107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    347291 | NS      | $1892735.95   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Aurinia Pharmaceuticals, Inc.                  | Aurinia Pharmaceuticals, Inc.                         | CUSIP: 05156V102<br>LEI: 5299008YP2BW4570ML28 | Long             | EC               | CORP              | CA        |    870678 | NS      | $13887314.10  | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Autolus Therapeutics plc                       | Autolus Therapeutics plc                              | CUSIP: 05280R100<br>LEI: 549300C0KZP8EYROLL02 | Long             | EC               | CORP              | GB        |   1357405 | NS      | $2701235.95   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Avidity Biosciences, Inc.                      | Avidity Biosciences, Inc.                             | CUSIP: 05370A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1018024 | NS      | $73430071.12  | 0.88%             |  |  |  | No            |                  1 | On Loan: No      |
| Axsome Therapeutics, Inc.                      | Axsome Therapeutics, Inc.                             | CUSIP: 05464T104<br>LEI: 549300EXGR0XLRJEIB95 | Long             | EC               | CORP              | US        |    304837 | NS      | $55675429.68  | 0.67%             |  |  |  | No            |                  1 | On Loan: No      |
| Bicara Therapeutics, Inc.                      | Bicara Therapeutics, Inc.                             | CUSIP: 055477103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    236617 | NS      | $3982264.11   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| BlackRock Funds III                            | BlackRock Cash Funds: Treasury, SL Agency Shares      | CUSIP: 066922477<br>LEI: 5493005PQV5UQG4OSI49 | Long             | STIV             | RF                | US        |   9410052 | NS      | $9410051.58   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| BlackRock Funds III                            | BlackRock Cash Funds: Institutional, SL Agency Shares | CUSIP: 066922519<br>LEI: 549300JDHS1T46VWOG19 | Long             | STIV             | RF                | US        |         0 | NS      | $0.20         | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Beam Therapeutics, Inc.                        | Beam Therapeutics, Inc.                               | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    675563 | NS      | $18726606.36  | 0.22%             |  |  |  | No            |                  1 | On Loan: —       |
| BeOne Medicines Ltd.                           | BeOne Medicines Ltd.                                  | CUSIP: 07725L102<br>LEI: 549300JFUK6FRD5MH739 | Long             | EC               | CORP              | CH        |    532992 | NS      | $161928299.52 | 1.94%             |  |  |  | No            |                  1 | On Loan: —       |
| Bicycle Therapeutics plc                       | Bicycle Therapeutics plc                              | CUSIP: 088786108<br>LEI: 213800XKUI6R7GKC3E43 | Long             | EC               | CORP              | GB        |    250705 | NS      | $1774991.40   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| BioCryst Pharmaceuticals, Inc.                 | BioCryst Pharmaceuticals, Inc.                        | CUSIP: 09058V103<br>LEI: 549300Z0INP1Z5NP6J59 | Long             | EC               | CORP              | US        |   1433779 | NS      | $11183476.20  | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| BioMarin Pharmaceutical, Inc.                  | BioMarin Pharmaceutical, Inc.                         | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |   1395406 | NS      | $82928978.58  | 0.99%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen, Inc.                                   | Biogen, Inc.                                          | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |   1079546 | NS      | $189989300.54 | 2.28%             |  |  |  | No            |                  1 | On Loan: —       |
| Bio-Techne Corp.                               | Bio-Techne Corp.                                      | CUSIP: 09073M104<br>LEI: 54930073RLKQ51TILZ35 | Long             | EC               | CORP              | US        |   1134458 | NS      | $66717474.98  | 0.80%             |  |  |  | No            |                  1 | On Loan: —       |
| BioNTech SE                                    | BioNTech SE                                           | CUSIP: 09075V102<br>LEI: 894500UZJ5LG1F8J1U58 | Long             | EC               | CORP              | DE        |    506696 | NS      | $48237459.20  | 0.58%             |  |  |  | No            |                  1 | On Loan: —       |
| BioAge Labs, Inc.                              | BioAge Labs, Inc.                                     | CUSIP: 09077V100<br>LEI: 529900NG0C40250Z7875 | Long             | EC               | CORP              | US        |    166068 | NS      | $2197079.64   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Black Diamond Therapeutics, Inc.               | Black Diamond Therapeutics, Inc.                      | CUSIP: 09203E105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    330226 | NS      | $802449.18    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| BridgeBio Oncology Therapeutics, Inc.          | BridgeBio Oncology Therapeutics, Inc.                 | CUSIP: 107924102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    318622 | NS      | $3989147.44   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Bridgebio Pharma, Inc.                         | Bridgebio Pharma, Inc.                                | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |   1212910 | NS      | $92775485.90  | 1.11%             |  |  |  | No            |                  1 | On Loan: —       |
| Bruker Corp.                                   | Bruker Corp.                                          | CUSIP: 116794108<br>LEI: LEBZ6VLQ6I8XB1NHVY15 | Long             | EC               | CORP              | US        |    759739 | NS      | $35791304.29  | 0.43%             |  |  |  | No            |                  1 | On Loan: No      |
| C4 Therapeutics, Inc.                          | C4 Therapeutics, Inc.                                 | CUSIP: 12529R107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    572683 | NS      | $1093824.53   | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Cabaletta Bio, Inc.                            | Cabaletta Bio, Inc.                                   | CUSIP: 12674W109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    623057 | NS      | $1364494.83   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Candel Therapeutics, Inc.                      | Candel Therapeutics, Inc.                             | CUSIP: 137404109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    302977 | NS      | $1711820.05   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| CareDx, Inc.                                   | CareDx, Inc.                                          | CUSIP: 14167L103<br>LEI: 549300NQOFKL9NON0U06 | Long             | EC               | CORP              | US        |    342499 | NS      | $6452681.16   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Cargo Therapeutics, Inc.                       | Cargo Therapeutics, Inc., CVR                         | CUSIP: 141CVR019<br>LEI: N/A                  | Long             |  | CORP              | US        |    198104 | NS      | $1.98         | 0.00%             |  |  |  | No            |                  3 | On Loan: —       |
| Caribou Biosciences, Inc.                      | Caribou Biosciences, Inc.                             | CUSIP: 142038108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    610552 | NS      | $970777.68    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Caris Life Sciences, Inc.                      | Caris Life Sciences, Inc.                             | CUSIP: 142152107<br>LEI: 549300LX5LO78M5VPY43 | Long             | EC               | CORP              | US        |    847969 | NS      | $22878203.62  | 0.27%             |  |  |  | No            |                  1 | On Loan: —       |
| Castle Biosciences, Inc.                       | Castle Biosciences, Inc.                              | CUSIP: 14843C105<br>LEI: 2549007M2Q4HLR1XD252 | Long             | EC               | CORP              | US        |    209849 | NS      | $8163126.10   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Cellectis SA                                   | Cellectis SA                                          | CUSIP: 15117K103<br>LEI: 5493000KKX5VQ37Q2W83 | Long             | EC               | CORP              | FR        |    337451 | NS      | $1633262.84   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Centessa Pharmaceuticals plc                   | Centessa Pharmaceuticals plc                          | CUSIP: 152309100<br>LEI: 213800GIDAARDSKOI827 | Long             | EC               | CORP              | GB        |    527820 | NS      | $13200778.20  | 0.16%             |  |  |  | No            |                  1 | On Loan: —       |
| CG oncology, Inc.                              | CG oncology, Inc.                                     | CUSIP: 156944100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    361070 | NS      | $14991626.40  | 0.18%             |  |  |  | No            |                  1 | On Loan: —       |
| Charles River Laboratories International, Inc. | Charles River Laboratories International, Inc.        | CUSIP: 159864107<br>LEI: 549300BSQ0R4UZ5KX287 | Long             | EC               | CORP              | US        |    358499 | NS      | $71513380.52  | 0.86%             |  |  |  | No            |                  1 | On Loan: —       |
| Contra Chinook Therape                         | Contra Chinook Therape, CVR                           | CUSIP: 169CVR016<br>LEI: N/A                  | Long             |  | CORP              | US        |    320962 | NS      | $54563.54     | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Codexis, Inc.                                  | Codexis, Inc.                                         | CUSIP: 192005106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    622174 | NS      | $1014143.62   | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Cogent Biosciences, Inc.                       | Cogent Biosciences, Inc.                              | CUSIP: 19240Q201<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    906831 | NS      | $32210637.12  | 0.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Compass Pathways plc                           | Compass Pathways plc                                  | CUSIP: 20451W101<br>LEI: 213800N7CUZIC6QSTZ31 | Long             | EC               | CORP              | GB        |    531502 | NS      | $3667363.80   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Contineum Therapeutics, Inc.                   | Contineum Therapeutics, Inc., Class A                 | CUSIP: 21217B100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    138307 | NS      | $1580849.01   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Corvus Pharmaceuticals, Inc.                   | Corvus Pharmaceuticals, Inc.                          | CUSIP: 221015100<br>LEI: 549300I3AVJ8F75NCX65 | Long             | EC               | CORP              | US        |    422724 | NS      | $3254974.80   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Crinetics Pharmaceuticals, Inc.                | Crinetics Pharmaceuticals, Inc.                       | CUSIP: 22663K107<br>LEI: 549300Q1CNFXK5P31D28 | Long             | EC               | CORP              | US        |    648955 | NS      | $30208855.25  | 0.36%             |  |  |  | No            |                  1 | On Loan: —       |
| Cullinan Therapeutics, Inc.                    | Cullinan Therapeutics, Inc.                           | CUSIP: 230031106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    290980 | NS      | $3011643.00   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Cytokinetics, Inc.                             | Cytokinetics, Inc.                                    | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |    884355 | NS      | $56191916.70  | 0.67%             |  |  |  | No            |                  1 | On Loan: —       |
| CytomX Therapeutics, Inc.                      | CytomX Therapeutics, Inc.                             | CUSIP: 23284F105<br>LEI: 5493004VW2FW0QLL3345 | Long             | EC               | CORP              | US        |    943527 | NS      | $4019425.02   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Cytek Biosciences, Inc.                        | Cytek Biosciences, Inc.                               | CUSIP: 23285D109<br>LEI: 549300K2J28BOC6FBO89 | Long             | EC               | CORP              | US        |    855225 | NS      | $4318886.25   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Day One Biopharmaceuticals, Inc.               | Day One Biopharmaceuticals, Inc.                      | CUSIP: 23954D109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    542721 | NS      | $5058159.72   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Denali Therapeutics, Inc.                      | Denali Therapeutics, Inc.                             | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |    962713 | NS      | $15894391.63  | 0.19%             |  |  |  | No            |                  1 | On Loan: —       |
| Design Therapeutics, Inc.                      | Design Therapeutics, Inc.                             | CUSIP: 25056L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    230710 | NS      | $2164059.80   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Disc Medicine, Inc.                            | Disc Medicine, Inc.                                   | CUSIP: 254604101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    197769 | NS      | $15704836.29  | 0.19%             |  |  |  | No            |                  1 | On Loan: —       |
| Dynavax Technologies Corp.                     | Dynavax Technologies Corp.                            | CUSIP: 268158201<br>LEI: 549300T5URIXWDILX594 | Long             | EC               | CORP              | US        |    861108 | NS      | $13243841.04  | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Dyne Therapeutics, Inc.                        | Dyne Therapeutics, Inc.                               | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    772857 | NS      | $15117082.92  | 0.18%             |  |  |  | No            |                  1 | On Loan: —       |
| Edgewise Therapeutics, Inc.                    | Edgewise Therapeutics, Inc.                           | CUSIP: 28036F105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    563150 | NS      | $13974567.25  | 0.17%             |  |  |  | No            |                  1 | On Loan: —       |
| Editas Medicine, Inc.                          | Editas Medicine, Inc.                                 | CUSIP: 28106W103<br>LEI: 5299000AON4Q9NT2JE42 | Long             | EC               | CORP              | US        |    716270 | NS      | $1468353.50   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Emergent BioSolutions, Inc.                    | Emergent BioSolutions, Inc.                           | CUSIP: 29089Q105<br>LEI: 549300YW6TUOX8BE5103 | Long             | EC               | CORP              | US        |    372235 | NS      | $4600824.60   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Enanta Pharmaceuticals, Inc.                   | Enanta Pharmaceuticals, Inc.                          | CUSIP: 29251M106<br>LEI: 529900SSN4DODDQSN594 | Long             | EC               | CORP              | US        |    202088 | NS      | $3186927.76   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Enliven Therapeutics, Inc.                     | Enliven Therapeutics, Inc.                            | CUSIP: 29337E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    319163 | NS      | $4915110.20   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Entrada Therapeutics, Inc.                     | Entrada Therapeutics, Inc.                            | CUSIP: 29384C108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    155655 | NS      | $1600133.40   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Erasca, Inc.                                   | Erasca, Inc.                                          | CUSIP: 29479A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1178517 | NS      | $4384083.24   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Exelixis, Inc.                                 | Exelixis, Inc.                                        | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |   1914022 | NS      | $83891584.26  | 1.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Standard BioTools, Inc.                        | Standard BioTools, Inc.                               | CUSIP: 34385P108<br>LEI: 549300GX8Y96GSB6YP89 | Long             | EC               | CORP              | US        |   2719234 | NS      | $3480619.52   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Foghorn Therapeutics, Inc.                     | Foghorn Therapeutics, Inc.                            | CUSIP: 344174107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    197351 | NS      | $1065695.40   | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Fortrea Holdings, Inc.                         | Fortrea Holdings, Inc.                                | CUSIP: 34965K107<br>LEI: 5493000FIVFABOVCDU97 | Long             | EC               | CORP              | US        |    678167 | NS      | $11698380.75  | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| 4D Molecular Therapeutics, Inc.                | 4D Molecular Therapeutics, Inc.                       | CUSIP: 35104E100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    375440 | NS      | $2815800.00   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Fulcrum Therapeutics, Inc.                     | Fulcrum Therapeutics, Inc.                            | CUSIP: 359616109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    354226 | NS      | $4006296.06   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Fulgent Genetics, Inc.                         | Fulgent Genetics, Inc.                                | CUSIP: 359664109<br>LEI: 549300CL6P01M68QJ404 | Long             | EC               | CORP              | US        |    147387 | NS      | $3871856.49   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Fusion Pharmaceuticals, Inc.                   | Fusion Pharmaceuticals, Inc., CVR                     | CUSIP: 361CVR012<br>LEI: N/A                  | Long             |  | CORP              | CA        |      1880 | NS      | $1034.00      | 0.00%             |  |  |  | No            |                  2 | On Loan: —       |
| Galapagos NV                                   | Galapagos NV                                          | CUSIP: 36315X101<br>LEI: 549300QKJ78IY0IOV655 | Long             | EC               | CORP              | BE        |    277822 | NS      | $9084779.40   | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| Genmab A/S                                     | Genmab A/S                                            | CUSIP: 372303206<br>LEI: 529900MTJPDPE4MHJ122 | Long             | EC               | CORP              | DK        |   3624517 | NS      | $111635123.60 | 1.34%             |  |  |  | No            |                  1 | On Loan: —       |
| Geron Corp.                                    | Geron Corp.                                           | CUSIP: 374163103<br>LEI: 549300T282D7Z2YESL90 | Long             | EC               | CORP              | US        |   4481249 | NS      | $5915248.68   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Gilead Sciences, Inc.                          | Gilead Sciences, Inc.                                 | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |   5484236 | NS      | $673135126.64 | 8.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Ginkgo Bioworks Holdings, Inc.                 | Ginkgo Bioworks Holdings, Inc.                        | CUSIP: 37611X209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    311534 | NS      | $2588847.54   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Gossamer Bio, Inc.                             | Gossamer Bio, Inc.                                    | CUSIP: 38341P102<br>LEI: 549300ZOC0N2W6PSFR58 | Long             | EC               | CORP              | US        |   1363754 | NS      | $4227637.40   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| GRAIL, Inc.                                    | GRAIL, Inc.                                           | CUSIP: 384747101<br>LEI: 2549009XSNESW3VE8024 | Long             | EC               | CORP              | US        |    247379 | NS      | $21173168.61  | 0.25%             |  |  |  | No            |                  1 | On Loan: —       |
| Grifols SA                                     | Grifols SA                                            | CUSIP: 398438408<br>LEI: 959800HSSNXWRKBK4N60 | Long             | EC               | CORP              | ES        |    925187 | NS      | $8650498.45   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Halozyme Therapeutics, Inc.                    | Halozyme Therapeutics, Inc.                           | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |    856502 | NS      | $57642584.60  | 0.69%             |  |  |  | No            |                  1 | On Loan: —       |
| Humacyte, Inc.                                 | Humacyte, Inc.                                        | CUSIP: 44486Q103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1166032 | NS      | $1119973.74   | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| NovaBridge Biosciences                         | NovaBridge Biosciences                                | CUSIP: 44975P103<br>LEI: 549300L1A5T19703RR64 | Long             | EC               | CORP              | KY        |    554104 | NS      | $2205333.92   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Ideaya Biosciences, Inc.                       | Ideaya Biosciences, Inc.                              | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |    618291 | NS      | $21374319.87  | 0.26%             |  |  |  | No            |                  1 | On Loan: —       |
| Illumina, Inc.                                 | Illumina, Inc.                                        | CUSIP: 452327109<br>LEI: SQ95QG8SR5Q56LSNF682 | Long             | EC               | CORP              | US        |   1094768 | NS      | $143589770.88 | 1.72%             |  |  |  | No            |                  1 | On Loan: —       |
| Immuneering Corp.                              | Immuneering Corp., Class A                            | CUSIP: 45254E107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    352505 | NS      | $2319482.90   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| ImmunityBio, Inc.                              | ImmunityBio, Inc.                                     | CUSIP: 45256X103<br>LEI: 529900J9XLBR4HFL4B83 | Long             | EC               | CORP              | US        |   2440909 | NS      | $4832999.82   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Immutep Ltd.                                   | Immutep Ltd.                                          | CUSIP: 45257L108<br>LEI: 529900OL6C5CY5P8BH38 | Long             | EC               | CORP              | AU        |    831110 | NS      | $2376974.60   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Immunocore Holdings plc                        | Immunocore Holdings plc                               | CUSIP: 45258D105<br>LEI: 213800IUE3DFS84BVN18 | Long             | EC               | CORP              | GB        |    283211 | NS      | $9830253.81   | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Immunovant, Inc.                               | Immunovant, Inc.                                      | CUSIP: 45258J102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    547153 | NS      | $13908629.26  | 0.17%             |  |  |  | No            |                  1 | On Loan: —       |
| Incyte Corp.                                   | Incyte Corp.                                          | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |   1431451 | NS      | $141384415.27 | 1.70%             |  |  |  | No            |                  1 | On Loan: No      |
| Inhibrx Biosciences, Inc.                      | Inhibrx Biosciences, Inc.                             | CUSIP: 45720N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     75082 | NS      | $5931478.00   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Insmed, Inc.                                   | Insmed, Inc.                                          | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |   1550263 | NS      | $269807772.52 | 3.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Intellia Therapeutics, Inc.                    | Intellia Therapeutics, Inc.                           | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |    810993 | NS      | $7290827.07   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Ionis Pharmaceuticals, Inc.                    | Ionis Pharmaceuticals, Inc.                           | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |   1170925 | NS      | $92631876.75  | 1.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Iovance Biotherapeutics, Inc.                  | Iovance Biotherapeutics, Inc.                         | CUSIP: 462260100<br>LEI: 2549002L8WT2ACU5Q878 | Long             | EC               | CORP              | US        |   2457604 | NS      | $6709258.92   | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Ironwood Pharmaceuticals, Inc.                 | Ironwood Pharmaceuticals, Inc., Class A               | CUSIP: 46333X108<br>LEI: 549300PC8MR6QHH6P296 | Long             | EC               | CORP              | US        |   1156209 | NS      | $3896424.33   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Perspective Therapeutics, Inc.                 | Perspective Therapeutics, Inc.                        | CUSIP: 46489V302<br>LEI: 5493005LRKM6BCABC605 | Long             | EC               | CORP              | US        |    461838 | NS      | $1270054.50   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Janux Therapeutics, Inc.                       | Janux Therapeutics, Inc.                              | CUSIP: 47103J105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    396958 | NS      | $5478020.40   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| KalVista Pharmaceuticals, Inc.                 | KalVista Pharmaceuticals, Inc.                        | CUSIP: 483497103<br>LEI: 529900Q7IDA3WUGRZA51 | Long             | EC               | CORP              | US        |    278810 | NS      | $4502781.50   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Zevra Therapeutics, Inc.                       | Zevra Therapeutics, Inc.                              | CUSIP: 488445206<br>LEI: 254900CU6T74V18Y1W18 | Long             | EC               | CORP              | US        |    412061 | NS      | $3692066.56   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Keros Therapeutics, Inc.                       | Keros Therapeutics, Inc.                              | CUSIP: 492327101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    209668 | NS      | $4268840.48   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Kodiak Sciences, Inc.                          | Kodiak Sciences, Inc.                                 | CUSIP: 50015M109<br>LEI: 254900IXI5NI8C9OQE24 | Long             | EC               | CORP              | US        |    361358 | NS      | $10103569.68  | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Krystal Biotech, Inc.                          | Krystal Biotech, Inc.                                 | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |    183505 | NS      | $45241322.70  | 0.54%             |  |  |  | No            |                  1 | On Loan: No      |
| Kura Oncology, Inc.                            | Kura Oncology, Inc.                                   | CUSIP: 50127T109<br>LEI: 5493005QORQTZCZYOP39 | Long             | EC               | CORP              | US        |    622461 | NS      | $6467369.79   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Kymera Therapeutics, Inc.                      | Kymera Therapeutics, Inc.                             | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    439597 | NS      | $34205042.57  | 0.41%             |  |  |  | No            |                  1 | On Loan: —       |
| Kyverna Therapeutics, Inc.                     | Kyverna Therapeutics, Inc.                            | CUSIP: 501976104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    154512 | NS      | $1452412.80   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Larimar Therapeutics, Inc.                     | Larimar Therapeutics, Inc.                            | CUSIP: 517125100<br>LEI: 529900NCBZHTTJV6HX73 | Long             | EC               | CORP              | US        |    344083 | NS      | $1310956.23   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Legend Biotech Corp.                           | Legend Biotech Corp.                                  | CUSIP: 52490G102<br>LEI: 254900EIUFZTW136H859 | Long             | EC               | CORP              | KY        |   1021110 | NS      | $22198931.40  | 0.27%             |  |  |  | No            |                  1 | On Loan: —       |
| LENZ Therapeutics, Inc.                        | LENZ Therapeutics, Inc.                               | CUSIP: 52635N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    205613 | NS      | $3289808.00   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Lexeo Therapeutics, Inc.                       | Lexeo Therapeutics, Inc.                              | CUSIP: 52886X107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    444857 | NS      | $4417430.01   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Lineage Cell Therapeutics, Inc.                | Lineage Cell Therapeutics, Inc.                       | CUSIP: 53566P109<br>LEI: 5299002BI4W22SDF8R25 | Long             | EC               | CORP              | US        |   1605044 | NS      | $2680423.48   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Lyell Immunopharma, Inc.                       | Lyell Immunopharma, Inc.                              | CUSIP: 55083R203<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     51816 | NS      | $1594896.48   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| MBX Biosciences, Inc.                          | MBX Biosciences, Inc.                                 | CUSIP: 55287L101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    195435 | NS      | $6164019.90   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Madrigal Pharmaceuticals, Inc.                 | Madrigal Pharmaceuticals, Inc.                        | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |    152049 | NS      | $88544214.66  | 1.06%             |  |  |  | No            |                  1 | On Loan: —       |
| MannKind Corp.                                 | MannKind Corp.                                        | CUSIP: 56400P706<br>LEI: 213800GFBCNY1ZFST722 | Long             | EC               | CORP              | US        |   2199441 | NS      | $12470830.47  | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Maravai LifeSciences Holdings, Inc.            | Maravai LifeSciences Holdings, Inc., Class A          | CUSIP: 56600D107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    779566 | NS      | $2533589.50   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Maze Therapeutics, Inc.                        | Maze Therapeutics, Inc.                               | CUSIP: 578784100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    192527 | NS      | $7976393.61   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Medpace Holdings, Inc.                         | Medpace Holdings, Inc.                                | CUSIP: 58506Q109<br>LEI: 549300H8TYEUVTW14A54 | Long             | EC               | CORP              | US        |    166574 | NS      | $93556287.10  | 1.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Mesoblast Ltd.                                 | Mesoblast Ltd.                                        | CUSIP: 590717401<br>LEI: 529900J5ALF3JG921927 | Long             | EC               | CORP              | AU        |    511502 | NS      | $9227496.08   | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| Mind Medicine MindMed, Inc.                    | Mind Medicine MindMed, Inc.                           | CUSIP: 60255C885<br>LEI: 549300QY8KN1O6RPFJ13 | Long             | EC               | CORP              | CA        |    705577 | NS      | $9447676.03   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Mineralys Therapeutics, Inc.                   | Mineralys Therapeutics, Inc.                          | CUSIP: 603170101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    415961 | NS      | $15095224.69  | 0.18%             |  |  |  | No            |                  1 | On Loan: —       |
| Mirum Pharmaceuticals, Inc.                    | Mirum Pharmaceuticals, Inc.                           | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |    309118 | NS      | $24417230.82  | 0.29%             |  |  |  | No            |                  1 | On Loan: —       |
| Moderna, Inc.                                  | Moderna, Inc.                                         | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |   2554875 | NS      | $75343263.75  | 0.90%             |  |  |  | No            |                  1 | On Loan: —       |
| Monte Rosa Therapeutics, Inc.                  | Monte Rosa Therapeutics, Inc.                         | CUSIP: 61225M102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    311464 | NS      | $4883755.52   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Myriad Genetics, Inc.                          | Myriad Genetics, Inc.                                 | CUSIP: 62855J104<br>LEI: 52990044IHUOUMETT163 | Long             | EC               | CORP              | US        |    654454 | NS      | $4024892.10   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Natera, Inc.                                   | Natera, Inc.                                          | CUSIP: 632307104<br>LEI: 529900CQ3OZ0A0VYVU59 | Long             | EC               | CORP              | US        |    968156 | NS      | $221794858.04 | 2.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Neumora Therapeutics, Inc.                     | Neumora Therapeutics, Inc.                            | CUSIP: 640979100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    401975 | NS      | $719535.25    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences, Inc.                   | Neurocrine Biosciences, Inc.                          | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |    715594 | NS      | $101492697.02 | 1.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurogene, Inc.                                | Neurogene, Inc.                                       | CUSIP: 64135M105<br>LEI: 529900A7VIY892SZVW73 | Long             | EC               | CORP              | US        |     97242 | NS      | $2003185.20   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Novavax, Inc.                                  | Novavax, Inc.                                         | CUSIP: 670002401<br>LEI: 529900J4GJHPEPQ23205 | Long             | EC               | CORP              | US        |   1094431 | NS      | $7354576.32   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Nuvalent, Inc.                                 | Nuvalent, Inc., Class A                               | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    353220 | NS      | $35530399.80  | 0.43%             |  |  |  | No            |                  1 | On Loan: —       |
| Nurix Therapeutics, Inc.                       | Nurix Therapeutics, Inc.                              | CUSIP: 67080M103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    736568 | NS      | $13972694.96  | 0.17%             |  |  |  | No            |                  1 | On Loan: —       |
| Nuvation Bio, Inc.                             | Nuvation Bio, Inc., Class A                           | CUSIP: 67080N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1765257 | NS      | $15816702.72  | 0.19%             |  |  |  | No            |                  1 | On Loan: —       |
| Olema Pharmaceuticals, Inc.                    | Olema Pharmaceuticals, Inc.                           | CUSIP: 68062P106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    467727 | NS      | $11693175.00  | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| OmniAb, Inc.                                   | OmniAb, Inc.                                          | CUSIP: 68218J103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    804690 | NS      | $1488676.50   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| OmniAb Operations, Inc.                        | OmniAb, Inc., 12.50 Earnout Shares                    | CUSIP: 68218J202<br>LEI: N/A                  | Long             |  | CORP              | US        |     46839 | NS      | $0.47         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| OmniAb, Inc.                                   | OmniAb, Inc., 15.00 Earnout Shares                    | CUSIP: 68218J301<br>LEI: N/A                  | Long             |  | CORP              | US        |     46839 | NS      | $0.47         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| OPKO Health, Inc.                              | OPKO Health, Inc.                                     | CUSIP: 68375N103<br>LEI: 529900A4S2D4OGOJLL02 | Long             | EC               | CORP              | US        |   2890901 | NS      | $3642535.26   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| ORIC Pharmaceuticals, Inc.                     | ORIC Pharmaceuticals, Inc.                            | CUSIP: 68622P109<br>LEI: 54930033FJRNEYBW0L25 | Long             | EC               | CORP              | US        |    395797 | NS      | $3237619.46   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Oruka Therapeutics, Inc.                       | Oruka Therapeutics, Inc.                              | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |    314864 | NS      | $9543527.84   | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| PTC Therapeutics, Inc.                         | PTC Therapeutics, Inc.                                | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |    568298 | NS      | $43167916.08  | 0.52%             |  |  |  | No            |                  1 | On Loan: No      |
| Pacific Biosciences of California, Inc.        | Pacific Biosciences of California, Inc.               | CUSIP: 69404D108<br>LEI: 529900F1BWRE1M0KZN89 | Long             | EC               | CORP              | US        |   1998541 | NS      | $3737271.67   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| PepGen, Inc.                                   | PepGen, Inc.                                          | CUSIP: 713317105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    434539 | NS      | $2828848.89   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Personalis, Inc.                               | Personalis, Inc.                                      | CUSIP: 71535D106<br>LEI: 549300EZ2NYFK7H0US48 | Long             | EC               | CORP              | US        |    391709 | NS      | $3118003.64   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Phathom Pharmaceuticals, Inc.                  | Phathom Pharmaceuticals, Inc.                         | CUSIP: 71722W107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    304898 | NS      | $5058257.82   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Praxis Precision Medicines, Inc.               | Praxis Precision Medicines, Inc.                      | CUSIP: 74006W207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    173044 | NS      | $51002988.56  | 0.61%             |  |  |  | No            |                  1 | On Loan: —       |
| Precigen, Inc.                                 | Precigen, Inc.                                        | CUSIP: 74017N105<br>LEI: 549300XCWNQU35K64G19 | Long             | EC               | CORP              | US        |   1101564 | NS      | $4604537.52   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Prime Medicine, Inc.                           | Prime Medicine, Inc.                                  | CUSIP: 74168J101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    692285 | NS      | $2402228.95   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Protagonist Therapeutics, Inc.                 | Protagonist Therapeutics, Inc.                        | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    435940 | NS      | $38074999.60  | 0.46%             |  |  |  | No            |                  1 | On Loan: No      |
| Pyxis Oncology, Inc.                           | Pyxis Oncology, Inc.                                  | CUSIP: 747324101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    354464 | NS      | $407633.60    | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| Quantum-Si, Inc.                               | Quantum-Si, Inc., Class A                             | CUSIP: 74765K105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1256606 | NS      | $1382266.60   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Quanterix Corp.                                | Quanterix Corp.                                       | CUSIP: 74766Q101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    277832 | NS      | $1767011.52   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| RAPT Therapeutics, Inc.                        | RAPT Therapeutics, Inc.                               | CUSIP: 75382E208<br>LEI: 549300MB473BIU78ES48 | Long             | EC               | CORP              | US        |    131880 | NS      | $4466775.60   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Rapport Therapeutics, Inc.                     | Rapport Therapeutics, Inc.                            | CUSIP: 75383L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    207272 | NS      | $6288632.48   | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Recursion Pharmaceuticals, Inc.                | Recursion Pharmaceuticals, Inc., Class A              | CUSIP: 75629V104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   3062211 | NS      | $12524442.99  | 0.15%             |  |  |  | No            |                  1 | On Loan: —       |
| Regeneron Pharmaceuticals, Inc.                | Regeneron Pharmaceuticals, Inc.                       | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |    745911 | NS      | $575746323.57 | 6.90%             |  |  |  | No            |                  1 | On Loan: No      |
| REGENXBIO, Inc.                                | REGENXBIO, Inc.                                       | CUSIP: 75901B107<br>LEI: 549300EOES47LATSET33 | Long             | EC               | CORP              | US        |    340393 | NS      | $4901659.20   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Relay Therapeutics, Inc.                       | Relay Therapeutics, Inc.                              | CUSIP: 75943R102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    960659 | NS      | $8127175.14   | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| Repligen Corp.                                 | Repligen Corp.                                        | CUSIP: 759916109<br>LEI: 54930006QJ0T5AUO1E71 | Long             | EC               | CORP              | US        |    392169 | NS      | $64260812.34  | 0.77%             |  |  |  | No            |                  1 | On Loan: —       |
| Replimune Group, Inc.                          | Replimune Group, Inc.                                 | CUSIP: 76029N106<br>LEI: 549300AY704NEIRC4K64 | Long             | EC               | CORP              | US        |    526067 | NS      | $5113371.24   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Revolution Medicines, Inc.                     | Revolution Medicines, Inc.                            | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |   1218511 | NS      | $97054401.15  | 1.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Rhythm Pharmaceuticals, Inc.                   | Rhythm Pharmaceuticals, Inc.                          | CUSIP: 76243J105<br>LEI: 529900JPNWXQ8DPLA551 | Long             | EC               | CORP              | US        |    459211 | NS      | $49153945.44  | 0.59%             |  |  |  | No            |                  1 | On Loan: —       |
| Rigel Pharmaceuticals, Inc.                    | Rigel Pharmaceuticals, Inc.                           | CUSIP: 766559702<br>LEI: 529900KPTNUS5J8K9K66 | Long             | EC               | CORP              | US        |    130388 | NS      | $5584518.04   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Rocket Pharmaceuticals, Inc.                   | Rocket Pharmaceuticals, Inc.                          | CUSIP: 77313F106<br>LEI: 549300R7VV82YUIN4Y93 | Long             | EC               | CORP              | US        |    734878 | NS      | $2579421.78   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Sagimet Biosciences, Inc.                      | Sagimet Biosciences, Inc., Class A                    | CUSIP: 786700104<br>LEI: 2549002OT2F8BV0VPD02 | Long             | EC               | CORP              | US        |    194309 | NS      | $1150309.28   | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Sana Biotechnology, Inc.                       | Sana Biotechnology, Inc.                              | CUSIP: 799566104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1224135 | NS      | $4982229.45   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| BlackRock Funds III                            | BlackRock Cash Funds: Institutional, SL Agency Shares | CUSIP: 066922519<br>LEI: 549300JDHS1T46VWOG19 | Long             | STIV             | RF                | US        | 808207480 | NS      | $808611584.01 | 9.70%             |  |  |  | No            |                  1 | On Loan: No      |
| Sarepta Therapeutics, Inc.                     | Sarepta Therapeutics, Inc.                            | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |    728690 | NS      | $15681408.80  | 0.19%             |  |  |  | No            |                  1 | On Loan: —       |
| Savara, Inc.                                   | Savara, Inc.                                          | CUSIP: 805111101<br>LEI: 5493002JO0WM3YMJXG33 | Long             | EC               | CORP              | US        |    634344 | NS      | $3825094.32   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Scholar Rock Holding Corp.                     | Scholar Rock Holding Corp.                            | CUSIP: 80706P103<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |    582635 | NS      | $25665071.75  | 0.31%             |  |  |  | No            |                  1 | On Loan: —       |
| Cartesian Therapeutics, Inc.                   | Cartesian Therapeutics, Inc.                          | CUSIP: 816212112<br>LEI: 529900NMN0LACZOL7C43 | Long             |  | CORP              | US        |      6098 | NS      | $1524.50      | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Septerna, Inc.                                 | Septerna, Inc.                                        | CUSIP: 81734D104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    198289 | NS      | $5528297.32   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Silence Therapeutics plc                       | Silence Therapeutics plc                              | CUSIP: 82686Q101<br>LEI: 213800SSURRJBX85SQ91 | Long             | EC               | CORP              | GB        |    176606 | NS      | $1073764.48   | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| ARS Pharmaceuticals, Inc.                      | ARS Pharmaceuticals, Inc.                             | CUSIP: 82835W108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    440702 | NS      | $5134178.30   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Sionna Therapeutics, Inc.                      | Sionna Therapeutics, Inc.                             | CUSIP: 829401108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    180588 | NS      | $7429390.32   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Solid Biosciences, Inc.                        | Solid Biosciences, Inc.                               | CUSIP: 83422E204<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    434779 | NS      | $2452153.56   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Stoke Therapeutics, Inc.                       | Stoke Therapeutics, Inc.                              | CUSIP: 86150R107<br>LEI: 549300RD25SS2DIJHJ67 | Long             | EC               | CORP              | US        |    338492 | NS      | $10743736.08  | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Structure Therapeutics, Inc.                   | Structure Therapeutics, Inc.                          | CUSIP: 86366E106<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |    334989 | NS      | $23298484.95  | 0.28%             |  |  |  | No            |                  1 | On Loan: —       |
| Summit Therapeutics, Inc.                      | Summit Therapeutics, Inc.                             | CUSIP: 86627T108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    759891 | NS      | $13290493.59  | 0.16%             |  |  |  | No            |                  1 | On Loan: —       |
| Sutro Biopharma, Inc.                          | Sutro Biopharma, Inc.                                 | CUSIP: 869367201<br>LEI: 5493005U6P15VD25P851 | Long             | EC               | CORP              | US        |        10 | NS      | $115.70       | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Syndax Pharmaceuticals, Inc.                   | Syndax Pharmaceuticals, Inc.                          | CUSIP: 87164F105<br>LEI: 529900OF94TRHKZVBS87 | Long             | EC               | CORP              | US        |    621798 | NS      | $13063975.98  | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Tango Therapeutics, Inc.                       | Tango Therapeutics, Inc.                              | CUSIP: 87583X109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    653854 | NS      | $5793146.44   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Tarsus Pharmaceuticals, Inc.                   | Tarsus Pharmaceuticals, Inc.                          | CUSIP: 87650L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    287511 | NS      | $23541400.68  | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Taysha Gene Therapies, Inc.                    | Taysha Gene Therapies, Inc.                           | CUSIP: 877619106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1654792 | NS      | $9101356.00   | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| Tectonic Therapeutic, Inc.                     | Tectonic Therapeutic, Inc.                            | CUSIP: 878972108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     73895 | NS      | $1541449.70   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Tenaya Therapeutics, Inc.                      | Tenaya Therapeutics, Inc.                             | CUSIP: 87990A106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1130233 | NS      | $804160.78    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Tempus AI, Inc.                                | Tempus AI, Inc.                                       | CUSIP: 88023B103<br>LEI: 2549009LA0KWRAGQBX50 | Long             | EC               | CORP              | US        |    749604 | NS      | $44264116.20  | 0.53%             |  |  |  | No            |                  1 | On Loan: —       |
| 10X Genomics, Inc.                             | 10X Genomics, Inc., Class A                           | CUSIP: 88025U109<br>LEI: 5493003Z6741WNLG7H43 | Long             | EC               | CORP              | US        |    826279 | NS      | $13476610.49  | 0.16%             |  |  |  | No            |                  1 | On Loan: —       |
| Terns Pharmaceuticals, Inc.                    | Terns Pharmaceuticals, Inc.                           | CUSIP: 880881107<br>LEI: 254900S1ZDQMF4MYP709 | Long             | EC               | CORP              | US        |    558663 | NS      | $22569985.20  | 0.27%             |  |  |  | No            |                  1 | On Loan: —       |
| Third Harmonic Bio, Inc.                       | Third Harmonic Bio, Inc.                              | CUSIP: 88427A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    134478 | NS      | $4034.34      | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Travere Therapeutics, Inc.                     | Travere Therapeutics, Inc.                            | CUSIP: 89422G107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    647382 | NS      | $24736466.22  | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Trevi Therapeutics, Inc.                       | Trevi Therapeutics, Inc.                              | CUSIP: 89532M101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    618243 | NS      | $7740402.36   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Twist Bioscience Corp.                         | Twist Bioscience Corp.                                | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |    427435 | NS      | $13558238.20  | 0.16%             |  |  |  | No            |                  1 | On Loan: —       |
| Tyra Biosciences, Inc.                         | Tyra Biosciences, Inc.                                | CUSIP: 90240B106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    268887 | NS      | $7069039.23   | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Ultragenyx Pharmaceutical, Inc.                | Ultragenyx Pharmaceutical, Inc.                       | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |    662394 | NS      | $15235062.00  | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| United Therapeutics Corp.                      | United Therapeutics Corp.                             | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |    306179 | NS      | $149185717.75 | 1.79%             |  |  |  | No            |                  1 | On Loan: No      |
| Upstream Bio, Inc.                             | Upstream Bio, Inc.                                    | CUSIP: 91678A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    189188 | NS      | $5136454.20   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Vanda Pharmaceuticals, Inc.                    | Vanda Pharmaceuticals, Inc.                           | CUSIP: 921659108<br>LEI: 529900AY8VOOQBKJ0O70 | Long             | EC               | CORP              | US        |    406462 | NS      | $3584994.84   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Vaxcyte, Inc.                                  | Vaxcyte, Inc.                                         | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |    934688 | NS      | $43126504.32  | 0.52%             |  |  |  | No            |                  1 | On Loan: —       |
| Ventyx Biosciences, Inc.                       | Ventyx Biosciences, Inc.                              | CUSIP: 92332V107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    472766 | NS      | $4269076.98   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Veracyte, Inc.                                 | Veracyte, Inc.                                        | CUSIP: 92337F107<br>LEI: 529900ESWZRHXOW27Z37 | Long             | EC               | CORP              | US        |    568303 | NS      | $23925556.30  | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Vera Therapeutics, Inc.                        | Vera Therapeutics, Inc., Class A                      | CUSIP: 92337R101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    358943 | NS      | $18176873.52  | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Vericel Corp.                                  | Vericel Corp.                                         | CUSIP: 92346J108<br>LEI: 54930076YM3PLTDR4B91 | Long             | EC               | CORP              | US        |    369153 | NS      | $13293199.53  | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals, Inc.                   | Vertex Pharmaceuticals, Inc.                          | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |   1591606 | NS      | $721570496.16 | 8.65%             |  |  |  | No            |                  1 | On Loan: No      |
| Vir Biotechnology, Inc.                        | Vir Biotechnology, Inc.                               | CUSIP: 92764N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    690357 | NS      | $4162852.71   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Voyager Therapeutics, Inc.                     | Voyager Therapeutics, Inc.                            | CUSIP: 92915B106<br>LEI: 54930082S4XVR0ZWCC74 | Long             | EC               | CORP              | US        |    337935 | NS      | $1328084.55   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Xencor, Inc.                                   | Xencor, Inc.                                          | CUSIP: 98401F105<br>LEI: 549300V5IF65437JKG30 | Long             | EC               | CORP              | US        |    494979 | NS      | $7578128.49   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Xenon Pharmaceuticals, Inc.                    | Xenon Pharmaceuticals, Inc.                           | CUSIP: 98420N105<br>LEI: 549300XV44Q9Z1MIPQ03 | Long             | EC               | CORP              | CA        |    549559 | NS      | $24631234.38  | 0.30%             |  |  |  | No            |                  1 | On Loan: —       |
| Zai Lab Ltd.                                   | Zai Lab Ltd.                                          | CUSIP: 98887Q104<br>LEI: 549300P2UYQ9U5LY1T58 | Long             | EC               | CORP              | KY        |    618941 | NS      | $10918119.24  | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Zenas Biopharma, Inc.                          | Zenas Biopharma, Inc.                                 | CUSIP: 98937L105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     97497 | NS      | $3540116.07   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Zymeworks, Inc.                                | Zymeworks, Inc.                                       | CUSIP: 98985Y108<br>LEI: 894500AHOYAGYLYZJL67 | Long             | EC               | CORP              | US        |    538063 | NS      | $14167198.79  | 0.17%             |  |  |  | No            |                  1 | On Loan: —       |
| Alkermes plc                                   | Alkermes plc                                          | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | IE        |   1188192 | NS      | $33245612.16  | 0.40%             |  |  |  | No            |                  1 | On Loan: No      |
| Biohaven Ltd.                                  | Biohaven Ltd.                                         | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | VG        |    650477 | NS      | $7343885.33   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| GH Research plc                                | GH Research plc                                       | CUSIP: N/A<br>LEI: 875500HKJS7QQG6EWH62       | Long             | EC               | CORP              | IE        |    330933 | NS      | $4202849.10   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| MeiraGTx Holdings plc                          | MeiraGTx Holdings plc                                 | CUSIP: N/A<br>LEI: 54930007YV6NYIOGFZ57       | Long             | EC               | CORP              | KY        |    430086 | NS      | $3419183.70   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Novocure Ltd.                                  | Novocure Ltd.                                         | CUSIP: N/A<br>LEI: 213800YPP55UMHWA4826       | Long             | EC               | CORP              | JE        |    740523 | NS      | $9574962.39   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Prothena Corp. plc                             | Prothena Corp. plc                                    | CUSIP: N/A<br>LEI: 5299009ZXQ8NIIJ8OL30       | Long             | EC               | CORP              | IE        |    320196 | NS      | $3057871.80   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Roivant Sciences Ltd.                          | Roivant Sciences Ltd.                                 | CUSIP: N/A<br>LEI: 549300DL466NY5J6U724       | Long             | EC               | CORP              | BM        |   3189208 | NS      | $69205813.60  | 0.83%             |  |  |  | No            |                  1 | On Loan: No      |
| Jyong Biotech Ltd.                             | Jyong Biotech Ltd.                                    | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | KY        |    212089 | NS      | $837751.55    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Theravance Biopharma, Inc.                     | Theravance Biopharma, Inc.                            | CUSIP: N/A<br>LEI: 5493007VTSXP4Z6MIW52       | Long             | EC               | CORP              | KY        |    348656 | NS      | $6523353.76   | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| AC Immune SA                                   | AC Immune SA                                          | CUSIP: N/A<br>LEI: 967600VLQ0ZC2HSOG765       | Long             | EC               | CORP              | CH        |    431153 | NS      | $1353820.42   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| ADC Therapeutics SA                            | ADC Therapeutics SA                                   | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | CH        |    732793 | NS      | $2586759.29   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| CRISPR Therapeutics AG                         | CRISPR Therapeutics AG                                | CUSIP: N/A<br>LEI: 506700O6IRRIQLT3W370       | Long             | EC               | CORP              | CH        |    673900 | NS      | $35339316.00  | 0.42%             |  |  |  | No            |                  1 | On Loan: —       |
| N/A                                            | XAV Health Care Index                                 | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |        28 | NC      | $26778.98     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Alvotech SA                                    | Alvotech SA                                           | CUSIP: N/A<br>LEI: 222100DCZBOWV5DZ8372       | Long             | EC               | CORP              | LU        |    805607 | NS      | $4132763.91   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| UroGen Pharma Ltd.                             | UroGen Pharma Ltd.                                    | CUSIP: N/A<br>LEI: 549300C0YCX7CG2G5D50       | Long             | EC               | CORP              | IL        |    284972 | NS      | $6674044.24   | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Atai Beckley NV                                | Atai Beckley NV                                       | CUSIP: N/A<br>LEI: 391200Z8UWPJSNBNCA11       | Long             | EC               | CORP              | NL        |   2010959 | NS      | $8224822.31   | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| CureVac NV                                     | CureVac NV                                            | CUSIP: N/A<br>LEI: 724500BUT8GAG9LMYN56       | Long             | EC               | CORP              | NL        |    436775 | NS      | $1974223.00   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| CureVac NV                                     | CureVac NV                                            | CUSIP: N/A<br>LEI: 724500BUT8GAG9LMYN56       | Long             | EC               | CORP              | NL        |    258448 | NS      | $1168184.96   | 0.01%             |  |  |  | No            |                  2 | On Loan: No      |
| Newamsterdam Pharma Co. NV                     | Newamsterdam Pharma Co. NV                            | CUSIP: N/A<br>LEI: 984500B6549TF6E14D36       | Long             | EC               | CORP              | NL        |    557086 | NS      | $19542576.88  | 0.23%             |  |  |  | No            |                  1 | On Loan: —       |
| Pharvaris NV                                   | Pharvaris NV                                          | CUSIP: N/A<br>LEI: 9845003BE146D3B75D32       | Long             | EC               | CORP              | NL        |    193992 | NS      | $5383278.00   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| uniQure NV                                     | uniQure NV                                            | CUSIP: N/A<br>LEI: 724500RPCTZLFYJZ3S98       | Long             | EC               | CORP              | NL        |    418895 | NS      | $10024157.35  | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| N/A                                            | Russell 2000 E-Mini Index                             | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |        22 | NC      | $-120791.68   | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Stevanato Group SpA                            | Stevanato Group SpA                                   | CUSIP: N/A<br>LEI: 81560033F7E1CD477507       | Long             | EC               | CORP              | IT        |    366061 | NS      | $7365147.32   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| WaVe Life Sciences Ltd.                        | WaVe Life Sciences Ltd.                               | CUSIP: N/A<br>LEI: 54930070006GPKFYZ813       | Long             | EC               | CORP              | SG        |    996003 | NS      | $16932051.00  | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2025-12-31

**Name of Applicant:** iShares Trust

**Signature:** Chuck Pulsfort

**Name of Signer:** Chuck Pulsfort

**Title:** Assistant Treasurer