# EDGAR Filing Document

**Accession Number:** 0001678660
**File Stem:** 0000929638-25-004602
**Filing Date:** 2025-12
**Character Count:** 2007
**Document Hash:** 4704f279fe785c5efedd58b07257b82c
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000929638-25-004602.hdr.sgml**: 20260608

**ACCESSION NUMBER**: 0000929638-25-004602

**CONFORMED SUBMISSION TYPE**: CORRESP

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20251215

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Prelude Therapeutics Inc
- **CENTRAL INDEX KEY:** 0001678660
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 811384762
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** CORRESP

**BUSINESS ADDRESS:**
- **STREET 1:** 175 INNOVATION BOULEVARD
- **CITY:** WILMINGTON
- **STATE:** DE
- **ZIP:** 19805
- **BUSINESS PHONE:** (302) 467-1280

**MAIL ADDRESS:**
- **STREET 1:** 175 INNOVATION BOULEVARD
- **CITY:** WILMINGTON
- **STATE:** DE
- **ZIP:** 19805

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Prelude Therapeutics Inc.
- **DATE OF NAME CHANGE:** 20160630

#### Prelude Therapeutics Inc.
175 Innovation Boulevard

Wilmington, Delaware 19805

December 15, 2025

#### VIA EDGAR TRANSMISSION

Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attention: Alan Campbell, Esq.

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| | |
|:---|:---|
| **Re:** | **Prelude Therapeutics Inc.<br> Registration Statement on Form S-3<br> Filed December 10, 2025<br> File No. 333-292048** |

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Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, Prelude Therapeutics Inc. hereby requests acceleration of the effective date of its Registration Statement on Form S-3 (File No. 333-292048), so that such registration statement may become effective at 4:00 p.m. (Washington, D.C. time) on December 16, 2025 or as soon as practicable thereafter.

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| | |
|:---|:---|
| PRELUDE THERAPEUTICS INC. | PRELUDE THERAPEUTICS INC. |
| By: | /s/ Krishna Vaddi, Ph.D. |
| Name:  | Krishna Vaddi, Ph.D. |
| Title: | Chief Executive Officer |

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