# EDGAR Filing Document

**Accession Number:** 0001232524
**File Stem:** 0001193125-23-004151
**Filing Date:** 2023-1
**Character Count:** 52058
**Document Hash:** ac176973b5d12c6733461286b1bd3ba8
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-23-004151.hdr.sgml**: 20230109

**ACCESSION NUMBER**: 0001193125-23-004151

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 49

**CONFORMED PERIOD OF REPORT**: 20230109

**ITEM INFORMATION**: Results of Operations and Financial Condition

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20230109

**DATE AS OF CHANGE**: 20230109

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Jazz Pharmaceuticals plc
- **CENTRAL INDEX KEY:** 0001232524
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 981032470
- **STATE OF INCORPORATION:** L2
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-33500
- **FILM NUMBER:** 23516577

**BUSINESS ADDRESS:**
- **STREET 1:** FIFTH FLOOR, WATERLOO EXCHANGE
- **STREET 2:** WATERLOO ROAD
- **CITY:** DUBLIN
- **STATE:** L2
- **ZIP:** 4
- **BUSINESS PHONE:** 353-1-634-7800

**MAIL ADDRESS:**
- **STREET 1:** FIFTH FLOOR, WATERLOO EXCHANGE
- **STREET 2:** WATERLOO ROAD
- **CITY:** DUBLIN
- **STATE:** L2
- **ZIP:** 4

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** JAZZ PHARMACEUTICALS INC
- **DATE OF NAME CHANGE:** 20030513

?xml version="1.0" encoding="utf-8" ? 8-K

------

### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION

#### WASHINGTON, D.C. 20549

------

### FORM 8-K

------

#### CURRENT REPORT

#### Pursuant to Section 13 or 15(d)

#### of the Securities Exchange Act of 1934

#### Date of Report (Date of earliest event reported) January 9, 2023

------

## JAZZ PHARMACEUTICALS PUBLIC LIMITED COMPANY

#### (Exact name of registrant as specified in its charter)

------

---

| | | |
|:---|:---|:---|
| **Ireland** | **001-33500** | **98-1032470** |
| **(State or Other Jurisdiction<br>of Incorporation)** | **(Commission<br>File No.)** | **(IRS Employer<br>Identification No.)** |

---

#### Fifth Floor, Waterloo Exchange, Waterloo Road, Dublin 4, Ireland

#### (Address of principal executive offices, including zip code)

#### 011-353-1-634-7800

#### (Registrant's telephone number, including area code)

------

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

---

| | | |
|:---|:---|:---|
| **Title of each class** | **Trading**<br> **Symbol(s)** | **Name of each exchange**<br> **on which registered** |
| Ordinary shares, nominal value $0.0001 per share | JAZZ | The Nasdaq Stock Market LLC |

---

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

------

---

| | |
|:---|:---|
| **Item 2.02.** | **Results of Operations and Financial Condition.** |

---

The January 9, 2023, Jazz Pharmaceuticals plc (the "Company") J.P. Morgan Healthcare Conference presentation includes a corporate overview and financial update, as well as the Company's expectations that it will meet its previously announced total, neuroscience and oncology revenue guidance ranges for the year ended December 31, 2022. A copy of the presentation is attached hereto as Exhibit 99.1.

The information contained in this Item 2.02 and in the accompanying Exhibit 99.1 of this Current Report on Form 8-K shall not be deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities of that Section or Sections 11 and 12(a)(2) of the Securities Act of 1933, as amended. The information contained in this Item 2.02 and in the accompanying Exhibit 99.1 of this Current Report on Form 8-K shall not be incorporated by reference into any filing with the U.S. Securities and Exchange Commission made by the Company, whether made before or after the date hereof, regardless of any general incorporation language in such filing.

---

| | |
|:---|:---|
| **Item 9.01.** | **Financial Statements and Exhibits.** |

---

*(d) Exhibits* 

---

| | |
|:---|:---|
| **Exhibit** <br>**Number** | **Description** |
| 99.1 | [Presentation slides by Jazz Pharmaceuticals plc on January 9, 2023](d442750dex991.htm) |
| 104 | Cover Page Interactive Data File (embedded within the Inline XBRL document) |

---

------

#### SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

---

| | |
|:---|:---|
| JAZZ PHARMACEUTICALS PUBLIC LIMITED COMPANY | JAZZ PHARMACEUTICALS PUBLIC LIMITED COMPANY |
| By: | /s/ Renée Galá |
| Name: | Renée Galá |
| Title: | Executive Vice President and Chief Financial Officer |
| Date: January 9, 2023 | Date: January 9, 2023 |

---

## Exhibit 99.1

![Slide 1](g442750ex99_1s1g1.jpg)

41st Annual J.P. Morgan Healthcare Conference Innovating to Transform the Lives of Patients and Their Families January 9, 2023 Grace Epidiolex patient Exhibit 99.1

------

![Slide 2](g442750ex99_1s2g1.jpg)

Transforming Lives. Redefining Possibilities. Caution Concerning Forward-Looking Statements This presentation contains forward-looking statements and financial targets, including, but not limited to, statements related to: the Company's growth prospects and future financial and operating results, including Vision 2025 and expectations related thereto; 2022 revenue guidance and the Company's expectations related thereto; the Company's ability to deliver sustainable growth and enhance value; the Company's commercial expectations, including with respect to revenue diversification, and its expectations for significant growth; the Company's ability to realize the commercial potential of its products, including the blockbuster potential for Epidiolex and its growth opportunities and the ability of Zepzelca to gain market share and its potential approval as a first line therapy; the value and growth potential of its products; the Company's net product sales, goals for net product sales from new and acquired products and net leverage ratio target; the Company's views and expectations relating to its patent portfolio, including with respect to expected patent protection; planned or anticipated clinical trial events, including with respect to initiations, enrollment and data read-outs, and the anticipated timing thereof, including completion of enrollment in the Zepzelca first line SCLC study and availability of zanidatamab's Phase III top-line GEA data; planned or anticipated regulatory submissions and filings; and other statements that are not historical facts. These forward-looking statements are based on the Company's current plans, objectives, estimates, expectations and intentions and inherently involve significant risks and uncertainties. Actual results and the timing of events could differ materially from those anticipated in such forward- looking statements as a result of these risks and uncertainties, which include, without limitation, risks and uncertainties associated with: maintaining or increasing sales of and revenue from the Company's oxybate products, Zepzelca and other key marketed products; effectively launching and commercializing the Company's other products and product candidates; obtaining and maintaining adequate coverage and reimbursement for the Company's products; the time-consuming and uncertain regulatory approval process, including the risk that the Company's current and/or planned regulatory submissions may not be submitted, accepted or approved by applicable regulatory authorities in a timely manner or at all, including the risk that the Company's sBLA seeking approval for a revised dosing label for Rylaze may not be approved by FDA in a timely manner or at all; the costly and time-consuming pharmaceutical product development and the uncertainty of clinical success, including risks related to failure or delays in successfully initiating or completing clinical trials and assessing patients such as those being experienced, and expected to continue to be experienced, by the Company; the Company's failure to realize the expected benefits of its acquisition of GW Pharmaceuticals, including the blockbuster potential of Epidiolex; regulatory initiatives and changes in tax laws; market volatility; protecting and enhancing the Company's intellectual property rights and the Company's commercial success being dependent upon its obtaining, maintaining and defending intellectual property protection for its products and product candidates; delays or problems in the supply or manufacture of the Company's products and product candidates; complying with applicable U.S. and non-U.S. regulatory requirements, including those governing the research, development, manufacturing and distribution of controlled substances; government investigations, legal proceedings and other actions; identifying and consummating corporate development transactions, financing these transactions and successfully integrating acquired product candidates, products and businesses; the Company's ability to realize the anticipated benefits of its collaborations and license agreements with third parties; the sufficiency of the Company's cash flows and capital resources; the Company's ability to achieve targeted or expected future financial performance and results and the uncertainty of future tax, accounting and other provisions and estimates; the completion of financial closing procedures, final audit adjustments and other developments that may arise that would cause the Company's expectations with respect to the Company's 2022 revenue guidance to differ, perhaps materially, from the financial results that will be reflected in the Company's audited consolidated financial statements for the fiscal year ended December 31, 2022; and other risks and uncertainties affecting the Company, including those described from time to time under the caption "Risk Factors" and elsewhere in the Company's Securities and Exchange Commission filings and reports, including the Company's Quarterly Report on Form 10-Q for the quarter ended September 30, 2022, and its future filings and reports. Other risks and uncertainties of which the Company is not currently aware may also affect its forward-looking statements and may cause actual results and the timing of events to differ materially from those anticipated. The forward-looking statements made in this presentation are made only as of the date hereof or as of the dates indicated in the forward-looking statements, even if they are subsequently made available by the Company on its website or otherwise. The Company undertakes no obligation to update or supplement any forward-looking statements to reflect actual results, new information, future events, changes in its expectations or other circumstances that exist after the date as of which the forward-looking statements were made.

------

![Slide 3](g442750ex99_1s3g1.jpg)

Transforming Lives. Redefining Possibilities. Non-GAAP Financial Measures To supplement Jazz Pharmaceuticals' financial results and guidance presented in accordance with U.S. generally accepted accounting principles (GAAP), the Company uses certain non-GAAP (also referred to as adjusted or non-GAAP adjusted) financial measures in this presentation. The Company presents non-GAAP adjusted net income which excludes from GAAP reported net income (loss) certain items, as detailed in the reconciliation tables that follow in the Appendix hereto, and adjusts for the income tax effect of the non-GAAP adjustments and the impact of the change in the statutory tax rate in the U.K. The Company also presents non-GAAP adjusted operating margin and projected non-GAAP adjusted operating margin improvement. Non-GAAP adjusted operating margin is calculated as total revenues less non-GAAP adjusted cost of product sales, SG&A expenses and R&D expenses divided by total revenues. Non-GAAP adjusted cost of product sales, SG&A expenses and R&D expenses exclude certain line item components from GAAP reported cost of product sales, SG&A expenses and R&D expenses, as detailed in the non-GAAP adjusted operating margin reconciliation table that follows in the Appendix hereto. The Company also uses a pro forma non-GAAP net leverage ratio calculated as net adjusted debt (defined as total GAAP debt, after giving effect to the Company's hedging arrangements for its Euro Term Loan B, net of cash, cash equivalents and investments) divided by Adjusted EBITDA for the most recent period of four consecutive completed fiscal quarters. EBITDA is defined as net income before income taxes, interest expense, depreciation and amortization. Adjusted EBITDA is defined as EBITDA further adjusted to exclude certain other charges and adjustments as detailed in the pro forma non-GAAP net leverage ratio reconciliation table that follows in the Appendix hereto and is calculated in accordance with the definition of Adjusted Consolidated EBITDA as set out in the Company's credit agreement entered into in May 2021 (the Credit Agreement). Investors should note that reconciliations of certain forward-looking or projected non-GAAP financial measures to their most comparable GAAP financial measures cannot be provided because the Company cannot do so without unreasonable efforts due to the unavailability of information needed to calculate reconciling items and due to the variability, complexity and limited visibility of comparable GAAP measures and the reconciling items that would be excluded from the non-GAAP financial measures in future periods. Likewise, reconciliations of projected non-GAAP adjusted cost of product sales, SG&A and R&D expenses, which are used to calculate projected non-GAAP adjusted operating margin and the related projected percentage improvement from 2021, to projected GAAP cost of product sales, SG&A and R&D expenses is not provided. For example, the non-GAAP adjustment for share-based compensation expense requires additional inputs such as the number and value of awards granted that are not currently ascertainable. Investors should note that the amounts of reconciling items between actual non-GAAP adjusted cost of product sales, SG&A and R&D expenses and actual GAAP cost of product sales, SG&A and R&D expenses could be significant such that actual GAAP cost of product sales, SG&A and R&D expenses would vary significantly from the projected adjusted cost of product sales, SG&A and R&D expenses used to calculate projected non-GAAP adjusted operating margin and the related projected percentage improvement from 2021. The Company believes that each of these non-GAAP financial measures provides useful supplementary information to, and facilitates additional analysis by, investors and analysts and that each of these non-GAAP financial measures, when considered together with the Company's financial information prepared in accordance with GAAP, can enhance investors' and analysts' ability to meaningfully compare the Company's results from period to period and to its forward-looking guidance, to identify operating trends in the Company's business and to understand the Company's ability to delever. In addition, these non-GAAP financial measures are regularly used by investors and analysts to model and track the Company's financial performance. The Company's management also regularly uses these non-GAAP financial measures internally to understand, manage and evaluate the Company's business and to make operating decisions, and compensation of executives is based in part on certain of these non-GAAP financial measures. Because these non-GAAP financial measures are important internal measurements for the Company's management, the Company also believes that these non-GAAP financial measures are useful to investors and analysts since these measures allow for greater transparency with respect to key financial metrics the Company uses in assessing its own operating performance and making operating decisions. These non-GAAP financial measures are not meant to be considered in isolation or as a substitute for comparable GAAP measures; should be read in conjunction with the Company's consolidated financial statements prepared in accordance with GAAP; have no standardized meaning prescribed by GAAP; and are not prepared under any comprehensive set of accounting rules or principles in the reconciliation tables that follow. In addition, from time to time in the future there may be other items that the Company may exclude for purposes of its non-GAAP financial measures; and the Company has ceased, and may in the future cease, to exclude items that it has historically excluded for purposes of its non-GAAP financial measures. Likewise, the Company may determine to modify the nature of its adjustments to arrive at its non-GAAP financial measures. Because of the non-standardized definitions of non-GAAP financial measures, the non-GAAP financial measures as used by the Company in this presentation and the accompanying tables have limits in their usefulness to investors and may be calculated differently from, and therefore may not be directly comparable to, similarly titled measures used by other companies.

------

![Slide 4](g442750ex99_1s4g1.jpg)

Our Purpose Who We Are is to innovate to transform the lives of patients and their families. We are focused on developing life-changing medicines for people with serious diseases, often with limited or no therapeutic options, so they can live their lives more fully. By transforming biopharmaceutical discoveries into novel medicines, we are working to give people around the world the opportunity to redefine what's possible, to make the "small wins" big again. Casey Xywav IH Patient Leighton Rylaze ALL Trial Participant IH = idiopathic hypersomnia; ALL = acute lymphoblastic leukemia

------

![Slide 5](g442750ex99_1s5g1.jpg)

Expect to meet 2022 total, neuroscience and oncology revenue guidance1 18% Revenue CAGR2 2017 – 2022 18 Consecutive Years YoY revenue growth 2005 – 2022 $3,094 Revenue $ in millions $3,600 - $3, 7001 CAGR – compound annual growth rate, YoY = year-over- year. 1Guidance provided by Jazz Pharmaceuticals plc on and as of November 9, 2022. The company expects that, for the year ended December 31, 2022, reported total, neuroscience and oncology revenues will meet the guidance range provided on November 9, 2022. Jazz Pharmaceuticals plc has not finalized its financial results for the year ended December 31, 2022, and actual results may differ. 2Based on mid-point of guidance provided by Jazz Pharmaceuticals plc on and as of November 9, 2022. Jazz Has A Track Record of Strong Execution

------

![Slide 6](g442750ex99_1s6g1.jpg)

Vision 2025 to Deliver Sustainable Growth and Enhanced Value PIPELINE Delivering ≥5 novel product approvals by end of the decade Generating $5 billion in revenue in 2025 COMMERCIAL Driving 5%1 adjusted operating margin2 improvement from 20213 to 2025 OPERATIONAL EXCELLENCE Vision 2025 represents Jazz estimates of future performance. 1Five percentage points; 2Adjusted operating margin is a non-GAAP financial measure. For further information, see "Non-GAAP Financial Measures"; 32021 adjusted operating margin calculation is included in the appendix for reference.

------

![Slide 7](g442750ex99_1s7g1.jpg)

Vision 2025 is Built on Our Core Strengths Vision 2025 represents Jazz estimates of future performance. 1Five percentage points; 2Adjusted operating margin is a non-GAAP financial measure. For further information, see "Non-GAAP Financial Measures"; 32021 adjusted operating margin calculation is included in the appendix for reference. Executing successful launches #1 treatment in narcolepsy & Epidiolex blockbuster potential Rapidly growing oncology business Ability to invest meaningfully in R&D Expanded R&D capabilities Breadth and depth of pipeline Strategic R&D collaborations Disciplined capital allocation Already achieved operating margin improvement - providing additional flexibility to invest in growth drivers PIPELINE Delivering ≥5 novel product approvals by end of the decade Generating $5 billion in revenue in 2025 COMMERCIAL Driving 5%1 adjusted operating margin2 improvement from 20213 to 2025 OPERATIONAL EXCELLENCE

------

![Slide 8](g442750ex99_1s8g1.jpg)

Strong 2022 Execution Positions Jazz Well to Achieve Vision 2025 2L = second line, BTC = Biliary tract cancer; CAGR = compound annual growth rate; IH = idiopathic hypersomnia, IM = intramuscular; IND = Investigational New Drug Application, M/W/F = Monday, Wednesday, Friday, PDT = Parkinson's disease tremor; SCLC = small cell lung cancer, YOY = Year-over-year. 1Based on 2022 guidance midpoint; 2United Kingdom, Germany, Italy, Spain and France ; 3YTD = Year-to-date September 30, 2022. Cash, cash equivalents and investments were $899.4 million as of September 30, 2022; 4Net leverage ratio (on a pro forma non-GAAP adjusted basis), adjusted EBITDA and adjusted operating margin are non-GAAP financial measures; FY 2022 G adjusted operating margin reconciliation is included in the Appendix; For further information, see "Non-GAAP Financial Measures". Xywav®: Compelling adoption across narcolepsy & IH drives oxybate durability Zepzelca®: Established as treatment of choice in 2L SCLC Rylaze®: Strong demand Significant YOY growth Now launched in all 5 key European markets2 Significant revenue growth 2017 to 2022 5-year CAGR of 18%1 Demonstrated launch excellence Epidiolex® blockbuster potential COMMERCIAL Added 3 exciting new molecules to pipeline in 2022 Zanidatamab: HER2-targeted bispecific antibody JZP441: Orexin-2 receptor agonist JZP898: IFNα INDUKINE™ molecule Significant 2022 R&D execution 4 INDs in 2022 & multiple additional INDs expected in 2023 7 clinical trials initiated Expanded suvecaltamide program into PDT Positive zanidatamab BTC top-line data Approval of Rylaze M/W/F IM PIPELINE Strong operational and financial foundation to deliver Vision 2025 is underpinned by: Strong operating cash flow of $930M YTD3 , ~$900M3 cash and $500M undrawn revolver 2022 projected adjusted operating margin4 of 49%1 provides additional flexibility to invest in growth drivers Delevered4 two full turns since close of GW transaction: Provides continued strategic flexibility Reduced total debt Increased adjusted EBITDA4 OPERATIONAL EXCELLENCE

------

![Slide 9](g442750ex99_1s9g1.jpg)

Strategic Transactions Drive Growth and Shareholder Value OPERATIONAL EXCELLENCE Corporate Development Progress Contributes to Vision 2025 Transformational Transaction GW ACQUISITION Epidiolex blockbuster potential Combined company - leader in neuroscience Global commercial and operational footprint well positioned to maximize the value of diversified portfolio Leadership Enhancing Transaction OREXIN-2 AGONIST Strengthens leadership in sleep Expands neuroscience pipeline Potential to be complementary to oxybate therapy Novel Late-Stage Asset Transaction ZANIDATAMAB Novel late-stage asset with compelling anti-tumor activity Positive top-line clinical data in BTC Phase 3 GEA top-line data expected in 2024 Rapidly Accretive Transaction ZEPZELCA Rapidly established as treatment of choice in 2L SCLC $535 million1 in revenue since launch in mid-2020 Robust development program underpins long-term commercial growth strategy Partner of Choice CORPORATE DEVELOPMENT Demonstrated commercial excellence Leader in neuroscience Rapidly growing oncology business Expanded R&D capabilities In-house development expertise 2L = second-line, BTC = biliary tract cancer, GEA = gastroesophageal adenocarcinoma, SCLC = small cell lung cancer. 1Net product sales from launch in July 2020 to September 30, 2022.

------

![Slide 10](g442750ex99_1s10g1.jpg)

Continuing to Rapidly Transform Revenue Base 1Guidance provided by Jazz Pharmaceuticals plc on and as of November 9, 2022. The company expects that, for the year ended December 31, 2022, reported total revenues will meet the guidance range provided on November 9, 2022. Jazz Pharmaceuticals plc has not finalized its financial results for the year ended December 31, 2022, and actual results may differ 2Chart based on YTD revenue reported in 3Q22. 3Vision 2025 represents Jazz estimates of future performance in 2025; 4Products launched or acquired since 2019. Vision 20253 $5 billion 2022 Revenue Guidance $3.6-$3.7 billion1 2019 Revenue $2.2 billion 46%2 24% Vision 2025: 60% of revenues driven by products other than oxybate Expect to Meet 2022 Target of 60-65% of Net Product Sales From Newer Products4 60% + Other commercial growth, existing pipeline and future corporate development + AG royalties of revenues driven by products other than oxybate

------

![Slide 11](g442750ex99_1s11g1.jpg)

Vision 2025 Execution: Commercial Generating $5 Billion in Revenue in 2025 January 2023

------

![Slide 12](g442750ex99_1s12g1.jpg)

Commercial Excellence Drives Growth …POSITIONS JAZZ WELL TO DELIVER ON VISION 2025 TRACK RECORD OF SUCCESSFUL COMMERCIAL EXECUTION… Leading neuroscience franchises #1 treatment in narcolepsy & global cannabinoid franchises Blockbuster potential Durable oxybate franchise Executing successful Xywav Launches ~$2 billion oxybate franchise ~$2.5 billion Epidiolex + oncology franchises ~$0.5 billion in other commercial growth, existing pipeline and future corporate development COMMERCIAL PIPELINE OPERATIONAL EXCELLENCE Rapidly growing oncology business Approaching $1B in revenue1, >$1B in 20252 Generating $5 billion in revenue in 20252 Rapidly established as the treatment-of-choice in 2L SCLC Strong demand in first year of launch 2L = second-line, SCLC = small cell lung cancer. 1Guidance provided by Jazz Pharmaceuticals plc on and as of November 9, 2022; 2Vision 2025 represents Jazz estimates of future performance.

------

![Slide 13](g442750ex99_1s13g1.jpg)

Xywav Success Reinforces Durable Oxybate Franchise 1Vision 2025 represents Jazz estimates of future performance. FDA = Food & Drug Administration, IH = idiopathic hypersomnia, HCP = healthcare provider, REMS = Risk Evaluation and Mitigation Strategy, AGs = Authorized generics FOUNDATION OF OXYBATE SUCCESS VISION 2025: ~$2 BILLION1 OXYBATE FRANCHISE For over 15 years Jazz has: Established oxybate therapy as the standard of care in narcolepsy Established and operated a robust, FDA approved, REMS and distribution system Built trust in sleep HCP and patient communities Provided patient support programs Invested to significantly improve oxybate therapy Existing Narcolepsy Market ~8,050 narcolepsy patients taking Xywav exiting 3Q22 New Narcolepsy Patients Opportunity to add patients previously not prescribed Xyrem based on sodium concerns Idiopathic Hypersomnia ~1,450 IH patients taking Xywav exiting 3Q22; new patient population; no other FDA approved treatments Meaningful future royalties on Xyrem AGs COMMERCIAL PIPELINE OPERATIONAL EXCELLENCE Compelling Xywav adoption in narcolepsy and IH

------

![Slide 14](g442750ex99_1s14g1.jpg)

Expansion into Idiopathic Hypersomnia Creates Growth Opportunity IH = idiopathic hypersomnia, FDA = Food and Drug Administration, MOA = mechanism of action Received Orphan Drug Exclusivity (ODE) in IH ~37,000 patients in the U.S. diagnosed & actively seeking healthcare Potential overall U.S. patient population: 70,000 – 80,000 patients Efficient launch with >90% overlap with existing sleep call universe FIRST AND ONLY FDA-APPROVED THERAPY TO TREAT IH IH is a serious and disruptive sleep disorder with high unmet need Distinct symptomatology and diagnostic criteria from other sleep disorders Xywav offers unique MOA to treat IH patients Rapid approval following narcolepsy launch COMMERCIAL PIPELINE OPERATIONAL EXCELLENCE NEAR-TERM VALUE DRIVER

------

![Slide 15](g442750ex99_1s15g1.jpg)

Executing Successful Xywav Launches Xywav on track to be oxybate of choice in 2023 Vision 20252: ~$2 billion oxybate franchise Compelling Xywav adoption across both narcolepsy and IH continues to drive oxybate durability Growth driven by both adoption and new patient starts 1Approximate active Xywav patients exiting quarter; 2Vision 2025 represents Jazz estimates of future performance. IH = idiopathic hypersomnia ACTIVE XYWAV PATIENTS1 7,800 Narcolepsy IH 6,900 8,700 9,500 250 COMMERCIAL PIPELINE OPERATIONAL EXCELLENCE

------

![Slide 16](g442750ex99_1s16g1.jpg)

Epidiolex: High Unmet Need in Pediatric Onset Epilepsy FDA = Food & Drug Administration, LGS = Lennox-Gastaut syndrome, TSC = tuberous sclerosis complex The first and only FDA-approved prescription cannabidiol The only treatment indicated for seizures associated with TSC, LGS, and Dravet syndrome in patients 1 year and older Broad-spectrum efficacy reducing multiple seizure types across TSC, LGS, and Dravet syndrome Opportunity for the most growth in LGS and TSC, as well as in treatment-resistant epilepsy and ex-U.S. LGS is one of the most difficult-to-treat epilepsy syndromes. In the U.S., there are ~30,000-50,000 patients with LGS TSC is a genetic disorder that causes non-malignant tumors to form in many different organs. In the U.S., there are ~40,000-50,000 patients with TSC 3.4 million U.S. patients with epilepsy. ~1/3 of patients are pharmacoresistant, with seizures persisting despite multiple anti-seizure medicines Committed to continuing to generate clinical study data and real-world evidence to further support the utility of Epidiolex across a broad range of difficult-to-treat seizure types COMMERCIAL PIPELINE OPERATIONAL EXCELLENCE Cammy Epidiolex Patient

------

![Slide 17](g442750ex99_1s17g1.jpg)

Epidiolex Revenue Growth Underscores Blockbuster Potential Net product sales ($ in millions) 19% year-over-year growth in LTM to 3Q22 driven by underlying demand Market research indicates nearly 60% of providers are using Epidiolex earlier in their treatment algorithm Continue to add new prescribers and grow Epidiolex's active prescriber base Volume of engagement with HCPs continues to grow Now launched in all five key European markets1 Robust patent estate with expiry dates out to 2035 and 2039 LTM = last twelve months, LTM 3Q21 presented on a pro-forma basis; HCP = healthcare providers. 1United Kingdom, Germany, Italy, Spain and France 19% revenue growth OPERATIONAL EXCELLENCE COMMERCIAL PIPELINE OPERATIONAL EXCELLENCE

------

![Slide 18](g442750ex99_1s18g1.jpg)

VISION 2025: >$1B1 2022G = Guidance provided by Jazz Pharmaceuticals plc on and as of November 9, 2022. 1Vision 2025 represents Jazz estimates of future performance. Rapidly Growing Oncology Business, Approaching $1B in Revenue COMMERCIAL PIPELINE OPERATIONAL EXCELLENCE Revenue $ in millions $860 - $920 U.S. Launch of Rylaze U.S. Launch of Zepzelca European rolling launch of Vyxeos U.S. Launch of Vyxeos U.S. Launch of Defitelio European Launch of Defitelio Acquired EUSA Pharma. Established our oncology business and European commercial infrastructure

------

![Slide 19](g442750ex99_1s19g1.jpg)

Zepzelca: Rapidly Established as Treatment of Choice in 2L SCLC 1L = first-line, 2L = second-line, SCLC = small cell lung cancer. 1Net product sales from launch in July 2020 to September 30, 2022; 2F. Hoffmann-La Roche Ltd. PIPELINE COMMERCIAL PIPELINE OPERATIONAL EXCELLENCE Established as 2L Treatment of Choice $535 million1 in revenue since launch in mid-2020 Demonstrated launch excellence Opportunities For Future Growth Continue to gain market share from topotecan and immuno-oncology products used as monotherapy Aim to increase share among patients being re-challenged with platinum-based chemotherapies Potential to Move Into 1L SCLC Phase 3 trial in extensive stage 1L SCLC in combination with Tecentriq® (atezolizumab), in collaboration with Roche2 Complete enrollment anticipated by year end 2023 Linda Zepzelca Patient

------

![Slide 20](g442750ex99_1s20g1.jpg)

Rely on Rylaze: Successful Launch and Strong Demand ALL/LBL = acute lymphoblastic leukemia / lymphoblastic lymphoma, EMA = European Medicines Agency, HCP = healthcare providers, IM = intramuscular, IV = intravenous, M/W/F = Monday, Wednesday, Friday, MAA = Marketing Authorisation Application, RTOR = Real-Time Oncology Review, sBLA = supplemental Biologics License Application. 1Net product sales from launch in July 2021 to September 30, 2022. 2Salzer W, Bostrom B, Messinger Y, et al. Asparaginase activity levels and monitoring in patients with acute lymphoblastic leukemia. Leuk Lymphoma. 2018;59(8):1797-1806. Significant Demand in 1st Year of Launch $286 million1 in revenue since launch in mid-2021 Maintaining periods of asparaginase activity over the course of therapy is essential to the treatment success of patients treated for ALL/LBL2 Medical education efforts are increasing understanding of switching therapy at first signs of hypersensitivity to E. coli-derived asparaginase Feedback from HCPs indicates that they are returning to best clinical practice due to unconstrained supply of Rylaze Regulatory Progress FDA approval of M/W/F IM dosing in November 2022 FDA sBLA IV administration submitted; under RTOR April 2022 MAA submission to EMA in May 2022; Potential for EU approval in 2023 Global Expansion Japan: Advancing the program for potential submission, approval and launch COMMERCIAL PIPELINE OPERATIONAL EXCELLENCE Willow Rylaze Patient

------

![Slide 21](g442750ex99_1s21g1.jpg)

Vision 2025 Execution: Pipeline Expanded Capabilities Driving Future Growth Potential January 2023

------

![Slide 22](g442750ex99_1s22g1.jpg)

Highly Productive R&D Engine Drives Value …POSITIONS JAZZ WELL TO DELIVER ON VISION 2025 TRACK RECORD OF SUCCESS, STRONG EXECUTION AND EXPANDED CAPABILITIES… COMMERCIAL PIPELINE OPERATIONAL EXCELLENCE Product approvals and launches in 2020–2021 Total pipeline projects Expanded >4x since 2015 Product approvals and commercial launches 11 since 2015 Molecules / programs acquired 26 since 2019 Breadth and depth of pipeline 29 R&D programs, 13 late-stage 3 exciting new molecules added through corporate development 5 >4x 11 26 Pipeline delivering ≥5 novel product approvals by end of the decade1 29 BTC = Biliary tract cancer, IM = intramuscular; IND = Investigational New Drug Application, M/W/F = Monday/Wednesday/Friday, PDT = Parkinson's disease tremor. 1Vision 2025 represents Jazz estimates of future performance. 2022 Execution Expanded suvecaltamide program to PDT 4 INDs in 2022 & multiple additional INDs expected in 2023 7 clinical trials initiated Positive zanidatamab BTC top-line data Approval of Rylaze M/W/F IM

------

![Slide 23](g442750ex99_1s23g1.jpg)

Expanded R&D Capabilities Provide Expertise and Scale COMMERCIAL PIPELINE OPERATIONAL EXCELLENCE Expanded In-house end-to-end drug development capabilities Enhanced medicinal chemistry & translational biology capabilities Differentiated capabilities in cannabinoids and nanoparticle drug delivery BREADTH AND DEPTH OF PIPELINE 23 novel candidates across neuroscience, oncology and cannabinoids 6 significant development collaborations DISCIPLINED CAPITAL ALLOCATION Significant ability to invest to drive sustainable growth SIGNIFICANT R&D EXPERTISE >700 R&D employees; >50% of Sr Director and above are PhD, PharmD or MDs Expertise in sleep medicine, hematological malignancies and solid tumors Patient-Centric Innovation Drives our Strategy

------

![Slide 24](g442750ex99_1s24g1.jpg)

PRE-CLINICAL PHASE 1 PHASE 2 PHASE 3 PHASE 4 / Regulatory KEY CATALYSTS Epidiolex Phase 3 Initiated Fourth target indication Phase 3 First Patient Enrolled JZP150 Phase 2 Top-line Data Readout Expected late 2023 Suvecaltamide (JZP385) Phase 2b Top-line Data Readout Expected 1H24 Phase 2 Initiated JZP441 Expect initial POC in healthy volunteers in 2023 Zanidatamab Positive top-line data Phase 3 Top-line Data Readout Expected 2024 Zepzelca Complete enrollment Anticipated by year-end 2023 Zepzelca Phase 2 Basket Trial First patient enrolled in 1Q22 Rylaze U.S.: sBLA submission for IV administration EU: EMA submission, potential approval 2023 Near-term R&D Pipeline Opportunities Neuroscience Oncology Cannabinoids 1L = first line, 2L = second-line, ALL/LBL = acute lymphoblastic leukemia/lymphoblastic lymphoma, DS = Dravet syndrome, EMA = European Medicines Agency, EMAS = epilepsy with myoclonic-atonic seizures, ES = extensive-stage, GEA = gastroesophageal adenocarcinoma, IV = intravenous, LGS = Lennox-Gastaut syndrome, POC = proof of concept; PTSD = post-traumatic stress disorder, sBLA = Supplemental Biologics License Application, SCLC = small cell lung cancer, TSC = Tuberous sclerosis complex. EMAS PTSD Phase 2b essential tremor ES 1L SCLC combo with Tecentriq ALL/LBL Solid Tumors Japan (LGS/TSC/DS) Parkinson's disease tremor Phase 3 1L GEA (pivotal) 2L Biliary Tract Cancer (pivotal) Orexin-2 Receptor Agonist Phase 3 2L SCLC confirmatory trial Phase 4 2L SCLC observational trial COMMERCIAL PIPELINE OPERATIONAL EXCELLENCE

------

![Slide 25](g442750ex99_1s25g1.jpg)

Vision 2025 Execution: Operational Excellence Financial Strength and Discipline Enables Future Growth January 2023

------

![Slide 26](g442750ex99_1s26g1.jpg)

Delivering Significant Value Through Strategic Capital Allocation 1As of September 30, 2022. COMMERCIAL PIPELINE OPERATIONAL EXCELLENCE CAPITAL DISCIPLINED DEPLOYMENT STRATEGIC PRIORITIES COMMERCIAL GROWTH New indications Geographic expansion PIPELINE EXPANSION Advancing internal assets Licensing new assets CORPORATE DEVELOPMENT Product acquisitions Company acquisitions STRONG FINANCIAL POSITION Deleveraged balance sheet Improved operating margin $Billions Expected cash flow through 2025 $0.5B Undrawn revolving credit facility1 $0.9B Cash, cash equivalents and investments1 Diversified and growing revenue base Differentiated pipeline to support future growth Operational excellence to maximize value

------

![Slide 27](g442750ex99_1s27g1.jpg)

Jazz Has Consistently Delivered Top- and Bottom-Line Growth REVENUE GROWTH GUIDED BY OUR PATIENT-CENTRIC APPROACH 2017 – 2022: 18% Revenue CAGR2 2005 – 2022: YoY revenue growth for 18 Consecutive years $3,094 Revenue $ in millions $3,600 - $3, 7001 operational excellence and operating margin improvements in 2022 position us well to achieve Vision 2025: 2016 - 2021: Achieved ~10% 5-year ANI3 CAGR 2022 guidance mid-point implies adjusted operating margin3 of 49% Provides significant flexibility to invest through 2023 and 2024 COMMERCIAL PIPELINE OPERATIONAL EXCELLENCE ANI = adjusted net income, CAGR – compound annual growth rate. 1Guidance provided by Jazz Pharmaceuticals plc on and as of November 9, 2022. The company expects that, for the year ended December 31, 2022, reported total revenues will meet the guidance range provided on November 9, 2022. Jazz Pharmaceuticals plc has not finalized its financial results for the year ended December 31, 2022, and actual results may differ; 2Based on mid-point of guidance. 3Non-GAAP adjusted net income and adjusted operating margin are non-GAAP financial measures. For further information see "Non-GAAP Financial Measures" and reconciliation tables in the Appendix.

------

![Slide 28](g442750ex99_1s28g1.jpg)

First ESG Report Published \*The 2021 ESG report is available on the Investors section of www.jazzpharmaceuticals.com and is based on data for the calendar year 2021. DEIB = diversity, equity, inclusion and belonging, ERTs = employee resource teams, ESG = environmental, social and governance, R&D = research and development PATIENTS Clinical trial safety and transparency Expanded areas of R&D focus Access and affordability of medicines DEIB 2025 goal: gender parity globally and 25-30% people of color in the U.S. at Executive Director levels and above 15% of workforce active in ERTs in 2021 Performance based executive compensation Community engagement and volunteerism Oncology medicine donations Corporate giving Medical education grants 100% of electricity from wind at Athlone facility 90% of water used at largest contracted cannabis growing site from rainwater harvesting Reduced packaging waste PEOPLE COMMUNITY PLANET

------

![Slide 29](g442750ex99_1s29g1.jpg)

Delivering Sustainable Growth and Shareholder Value COMMERCIAL OPERATIONAL EXCELLENCE Transforming Lives. Redefining Possibilities. COMMERCIAL PIPELINE OPERATIONAL EXCELLENCE Patient-centric innovation drives our strategy 2022 execution positions us well to achieve Vision 2025 Strong financial foundations with additional flexibility to invest and transact to grow our business Promising pipeline with significant near-, mid- and longer-term catalysts Expanded R&D capabilities and commercial excellence drive corporate development 'partner of choice' status

------

![Slide 30](g442750ex99_1s30g1.jpg)

Thank You January 2023

------

![Slide 31](g442750ex99_1s31g1.jpg)

Appendix January 2023

------

![Slide 32](g442750ex99_1s32g1.jpg)

1Partnered collaboration; 2Recently acquired; 3Planned; 4Jazz & MD Anderson Cancer Center collaboration study; 5JZP150 is a fatty acid amide hydrolase inhibitor which modulates the endocannabinoid anandamide; 6HERIZON-BTC-01; 7Cooperative group study; 8HERIZON-GEA-01; 9FDA approval on June 30, 2021 and FDA approval of sBLA for MWF IM dosing on November 18, 2022; submitted additional data to support U.S. label update. 1L = first line, ALL/LBL = acute lymphoblastic leukemia / lymphoblastic lymphoma, AML = acute myeloid leukemia, COG = Children's Oncology Group, BTC = biliary tract cancer, CRC = colorectal cancer, DS = Dravet syndrome, EMAS = epilepsy with myoclonic-atonic seizures, GEA = gastroesophageal adenocarcinoma, HMA = hypomethylating agents, HR = high-risk, HRD+ = homologous recombinant deficient positive, LGS = Lennox-Gastaut syndrome, MDS = myelodysplastic syndromes, PTSD = post-traumatic stress disorder, R/R = relapsing/refractory, SCLC = small cell lung cancer, SG = study group, TSC = Tuberous sclerosis complex. Neuroscience Oncology Cannabinoids PHASE 1 JZP351 (Vyxeos) Low Intensity Dosing for higher risk MDS4 JZP3243 Oxybate extended-release formulation Additional Cannabinoids Neonatal hypoxic-ischemic encephalopathy Additional Cannabinoids Neuropsychiatry targets PRE-CLINICAL CombiPlex Exploratory activities JZP341 (Long-acting Erwinia asparaginase) Solid tumors JZP815 Pan-Raf Inhibitor Program Raf & Ras mutant tumors Exosome targets (Up to 3 targets)1 Hematological malignancies/solid tumors Undisclosed targets Oncology Undisclosed targets Neuroscience Undisclosed target Ras/Raf/MAP kinase pathway1 Undisclosed targets Cannabinoids PHASE 3 JZP351 AML or HR-MDS >60yrs (AML18)7 Newly diagnosed adults with standard- and HR-AML (AMLSG)7 Newly diagnosed <22 yrs with AML (COG)4 Lurbinectedin1 1L treatment SCLC in combination with Tecentriq® (atezolizumab) Cannabidiol (Epidiolex) EMAS REGULATORY JZP458 (Rylaze)9 (recombinant Erwinia asparaginase) ALL/LBL Suvecaltamide (JZP385) Essential tremor PHASE 2 JZP351 + venetoclax de novo or R/R AML4 JZP351 HR-MDS (EMSCO)7 Newly diagnosed older adults with HR-AML7 JZP1505 PTSD Lurbinectedin (Zepzelca) Basket trial: advanced urothelial cancer, large cell neuroendocrine tumor of the lung, HRD+ cancers JZP351 + other approved therapies R/R AML or HMA Failure MDS4 First-line, fit AML (Phase 1b) Low Intensity Therapy for first-line, unfit AML (Phase 1b) JZP898 (WTX-613)2 Conditionally-activated IFNα JZP441 (DSP-0187)2 Orexin-2 receptor agonist Suvecaltamide (JZP385) Parkinson's Disease Tremor Additional Cannabinoids Autism spectrum disorders Cannabidiol (Epidyolex) LGS, DS, TSC in Japan Zanidatamab2 HER2-targeted bispecific antibody Breast cancer Zanidatamab2 HER2-targeted bispecific antibody 2L zani monotherapy for BTC7 (Pivotal trial) Additional trials ongoing in BTC, GEA and CRC Multiple trials ongoing in breast cancer Zanidatamab2 HER2-targeted bispecific antibody 1L zani + chemo ± tislelizumab for GEA8 (Pivotal trial) Robust and Productive Pipeline for Sustainable Growth

------

![Slide 33](g442750ex99_1s33g1.jpg)

In millions, except % (unaudited) Year ended December 31, 2021 Revenue $3,094 Adjusted cost of product sales, SG&A and R&D expenses $1,761 Non-GAAP adjusted operating margin 43% In millions (unaudited) Cost of product sales SG&A R&D Total GAAP reported $441 $1,452 $506 $2,398 Share-based compensation (11) (118) (42) (170) Transaction and integration related expenses (2) (229) (13) (244) Acquisition accounting inventory fair value step-up (223) — — (223) Total of non-GAAP adjusted $205 $1,105 $451 $1,761 Non-GAAP Adjusted Operating Margin1 – Year Ended December 31, 2021 The following table provides a reconciliation of the Company's GAAP reported cost of product sales, SG&A expenses and R&D expenses to non-GAAP adjusted cost of products sales, SG&A expenses and R&D expenses and the calculation of the Company's non-GAAP adjusted operating margin. SG&A = selling, general and administrative, R&D = research and development. 1Adjusted operating margin is a non-GAAP financial measure. For further information, see "Non-GAAP Financial Measures". Note: Table may not foot due to rounding.

------

![Slide 34](g442750ex99_1s34g1.jpg)

In millions, except % (unaudited) FY 2022 G Revenue $3,650 Adjusted cost of product sales, SG&A and R&D expenses $1,866 Non-GAAP adjusted operating margin 49% In millions (unaudited) Cost of product sales G SG&A G R&D G Total G GAAP $541 $1,360 $578 $2,479 Share-based compensation (12) (140) (59) (211) Restructuring and other charges (2) (43) (12) (57) Transaction and integration related expenses (1) (27) (2) (30) Costs related to disposal of a business — (45) — (45) Acquisition accounting inventory fair value step-up (270) — — (270) Total of non-GAAP adjusted $256 $1,105 $505 $1,866 Non-GAAP Adjusted Operating Margin1,2 – FY 2022 G The following table provides a reconciliation of the Company's projected 2022 GAAP cost of product sales, SG&A expenses and R&D expenses guidance to non-GAAP adjusted cost of products sales, SG&A expenses and R&D expenses guidance and the calculation of the Company's non-GAAP adjusted operating margin. Note: Table may not foot due to rounding. G= Guidance. R&D = research and development, SG&A = selling, general and administrative. 1Calculated at the midpoint; 2Adjusted operating margin is a non-GAAP financial measure. For further information, see "Non-GAAP Financial Measures".

------

![Slide 35](g442750ex99_1s35g1.jpg)

Pro Forma Non-GAAP Net Leverage Ratio Reconciliation of Pro Forma GAAP Net income to Pro Forma Non-GAAP Adjusted EBITDA1 (calculated in accordance with the Company's Credit Agreement) and the Calculation of Pro Forma Non-GAAP Net Leverage Ratio In millions (unaudited) LTM Ended 09/30/22 LTM Ended 03/31/21 Pro forma GAAP net income $462 $4483 Interest expense, net 303 109 Income tax (benefit) expense (71) 102 Depreciation and amortization 6334 298 Pro forma non-GAAP EBITDA 911 957 Transaction and integration related expenses 66 25 Share-based compensation expense 1964 192 Acquisition accounting inventory fair value step-up 278 - Restructuring and other costs 58 - Impairment charge 134 - Upfront and milestone payments 85 50 Costs related to the disposal of a business 50 - Other (62) 26 Expected cost synergies5 10 45 Pro forma non-GAAP Adjusted EBITDA1 $1,724 $1,296 In millions, except ratio (unaudited) At 09/30/2022 At 05/05/21 Calculation of Net Debt: Total GAAP debt $5,836 $7,144 Impact of current hedging arrangements on Euro Term Loan B - 3 Total Adjusted Debt6 $5,836 7,147 Cash, cash equivalents and investments (899) (799)7 Net Adjusted Debt $4,937 $6,348 Calculation of Pro Forma non-GAAP Net Leverage Ratio: Net Adjusted Debt $4,937 $6,348 Pro forma non-GAAP Adjusted EBITDA1 $1,724 $1,296 Pro Forma non-GAAP Net Leverage Ratio4 2.9 4.9 1Pro forma non-GAAP Adjusted EBITDA is calculated in accordance with the definition of Consolidated Adjusted EBITDA as set out in the Credit Agreement; 2Pro forma GAAP net income is derived from the GAAP financial statements of the Company for the LTM ended September 30, 2022, and in accordance with the Credit Agreement reflects the divestment of Sunosi U.S. to Axsome on a proforma basis as if the divestment had occurred at the beginning of the LTM ended September 30, 2022. 3Pro forma GAAP net income is derived from the GAAP financial statements of the Company and GW for this period. 4Excludes the portion of these adjustments related to the Sunosi U.S. business; 5Expected cost synergies of $45M from initiatives implemented following the acquisition of GW are assumed to be realized pro-rata through 2022. 6Total adjusted debt, reflected the impact of the Company's hedging arrangements on the Euro term Loan B, in accordance with the Credit Agreement, the Euro term Loan B was repaid in March 2022; 7Cash and cash equivalents is derived from historical Jazz Pharmaceuticals plc and GW and is pro forma for the close of the acquisition of GW (the GW Acquisition) on May 5, 2021 after giving effect to the settlement of the cash consideration, fees and expenses of the transaction and repayment of the outstanding balance on the term loan A which was terminated on close of the GW Acquisition. LTM = Last Twelve Months; EBITDA = Earnings Before Interest, Income Tax, Depreciation and Amortization; GW = GW Pharmaceuticals plc. Note: Table may not foot due to rounding.

------

![Slide 36](g442750ex99_1s36g1.jpg)

Explanation of Adjustments and Certain Line Items: Transaction and integration expenses in 2021 related to the GW Acquisition and in 2016 related to the Celator Acquisition. Non-cash interest expense associated with debt discount and debt issuance costs. Expense arising on the remeasurement of the Company's U.K. net deferred tax liability, which arose primarily in relation to the GW Acquisition, due to a change in the statutory tax rate in the U.K. following enactment of the UK Finance Act 2021. Commencing in 2020, following consultation with the staff of the Division of Corporation Finance of the U.S. Securities and Exchange Commission, the Company no longer excludes upfront and milestone payments from the Company's non-GAAP adjusted net income. For the purposes of comparability, non-GAAP adjusted financial measures for the year end December 31, 2016 have been updated to reflect this change. Year ended 31 December In millions (unaudited) 2021 2016 GAAP reported net income (loss) $(329,668) $396,831 Intangible asset amortization 525,769 101,994 Share-based compensation expense 169,921 98,771 Transaction and integration related expenses1 243,710 13,644 Non-cash interest expense2 92,655 22,133 Acquisition accounting inventory fair value step-up 223,085 — Expenses related to certain legal proceedings and restructuring — 6,060 Loss on extinguishment and modification of debt — 638 Income tax effect of above adjustments (192,521) (36,659) Impact of U.K. tax rate change3 259,873 — Non-GAAP adjusted net income $992,824 $603, 4124 Reconciliation of GAAP Reported Net Income (Loss) to Non-GAAP Adjusted Net Income† †Non-GAAP adjusted net income is a non-GAAP financial measure. For further information see "Non-GAAP Financial Measures".