# EDGAR Filing Document

**Accession Number:** 0001224962
**File Stem:** 0001012975-23-000099
**Filing Date:** 2023-2
**Character Count:** 13612
**Document Hash:** 19508172e1634392cfccb296c469e957
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001012975-23-000099.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001012975-23-000099

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**EFFECTIVENESS DATE**: 20230214

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** PERCEPTIVE ADVISORS LLC
- **CENTRAL INDEX KEY:** 0001224962
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-10438
- **FILM NUMBER:** 23629645

**BUSINESS ADDRESS:**
- **STREET 1:** 51 ASTOR PLACE, 10TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10003
- **BUSINESS PHONE:** 646-205-5300

**MAIL ADDRESS:**
- **STREET 1:** 51 ASTOR PLACE, 10TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10003

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2022

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** PERCEPTIVE ADVISORS LLC<br>**Address:** 51 ASTOR PLACE 10TH FLOOR<br>NEW YORK, NY 10003

**Form 13F File Number:** 028-10438

**CRD Number (if applicable):** 000154703

**SEC File Number (if applicable):** 801-71841

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Joseph Edelman<br>**Title:** Managing Member<br>**Phone:** 646-205-5342

**Signature, Place, and Date of Signing:**

/s/ Joseph Edelman  New York, NY  02-14-2023<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 96

**Form 13F Information Table Value Total:** $3561179764

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 |  | 5374514 | 341239 | SH |  | SOLE |  | 341239 | 0 | 0 |
| ACRIVON THERAPEUTICS INC | COMMON STOCK | 004890109 |  | 34650524 | 3007858 | SH |  | SOLE |  | 3007858 | 0 | 0 |
| ACUMEN PHARMACEUTICALS INC | COM | 00509G209 |  | 1876230 | 347450 | SH |  | SOLE |  | 347450 | 0 | 0 |
| ADMA BIOLOGICS INC | COM | 000899104 |  | 46172989 | 11900255 | SH |  | SOLE |  | 11900255 | 0 | 0 |
| AKERO THERAPEUTICS INC | COM | 00973Y108 |  | 19208770 | 350525 | SH |  | SOLE |  | 350525 | 0 | 0 |
| ALBIREO PHARMA INC | COM | 01345P106 |  | 37972228 | 1757160 | SH |  | SOLE |  | 1757160 | 0 | 0 |
| ALDEYRA THERAPEUTICS INC | COM | 01438T106 |  | 78996592 | 11350085 | SH |  | SOLE |  | 11350085 | 0 | 0 |
| AMICUS THERAPEUTICS INC | COM | 03152W109 |  | 337520017 | 27642917 | SH |  | SOLE |  | 27642917 | 0 | 0 |
| AMYLYX PHARMACEUTICALS INC | COM | 03237H101 |  | 224963904 | 6088333 | SH |  | SOLE |  | 6088333 | 0 | 0 |
| ARCELLX INC | COMMON STOCK | 03940C100 |  | 80495489 | 2598305 | SH |  | SOLE |  | 2598305 | 0 | 0 |
| ARTIVION INC | COM | 228903100 |  | 13160623 | 1085860 | SH |  | SOLE |  | 1085860 | 0 | 0 |
| ASTRIA THERAPEUTICS INC | COM | 04635X102 |  | 32601089 | 2189462 | SH |  | SOLE |  | 2189462 | 0 | 0 |
| ATHENEX INC | COM | 04685N103 |  | 2291039 | 15532467 | SH |  | SOLE |  | 15532467 | 0 | 0 |
| ATHIRA PHARMA INC | COM | 04746L104 |  | 15207371 | 4797278 | SH |  | SOLE |  | 4797278 | 0 | 0 |
| AXOGEN INC | COM | 05463X106 |  | 13853497 | 1388126 | SH |  | SOLE |  | 1388126 | 0 | 0 |
| BELLUS HEALTH INC NEW | COM NEW | 07987C204 |  | 73084242 | 8891027 | SH |  | SOLE |  | 8891027 | 0 | 0 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 |  | 52415719 | 506481 | SH |  | SOLE |  | 506481 | 0 | 0 |
| BRIDGEBIO PHARMA  INC | COM | 10806X102 |  | 12931391 | 1697033 | SH |  | SOLE |  | 1697033 | 0 | 0 |
| CABALETTA BIO INC | COM | 12674W109 |  | 2936450 | 317454 | SH |  | SOLE |  | 317454 | 0 | 0 |
| CAREMAX INC | COM CL A | 14171W103 |  | 11421562 | 3129195 | SH |  | SOLE |  | 3129195 | 0 | 0 |
| CAREMAX INC | *W EXP 06/08/202 | 14171W111 |  | 31308 | 60000 | SH |  | SOLE |  | 60000 | 0 | 0 |
| CASSAVA SCIENCES INC | COM | 14817C107 |  | 4431000 | 150000 | SH | Put | SOLE |  | 150000 | 0 | 0 |
| CEREVEL THERAPEUTICS HLDNG I | COM | 15678U128 |  | 205379869 | 6511727 | SH |  | SOLE |  | 6511727 | 0 | 0 |
| CINCOR PHARMA INC | COM | 17240Y109 |  | 31663034 | 2576325 | SH |  | SOLE |  | 2576325 | 0 | 0 |
| CLOVER HEALTH INVESTMENTS CO | COM CL A | 18914F103 |  | 1394250 | 1500000 | SH |  | SOLE |  | 1500000 | 0 | 0 |
| COGENT BIOSCIENCES INC | COM | 19240Q201 |  | 37078018 | 3207441 | SH |  | SOLE |  | 3207441 | 0 | 0 |
| CRINETICS PHARMACEUTICALS IN | COM | 22663K107 |  | 73918751 | 4039276 | SH |  | SOLE |  | 4039276 | 0 | 0 |
| CYMABAY THERAPEUTICS INC | COM | 23257D103 |  | 4445386 | 708993 | SH |  | SOLE |  | 708993 | 0 | 0 |
| CYTEK BIOSCIENCES INC | COM | 23285D109 |  | 13166142 | 1289534 | SH |  | SOLE |  | 1289534 | 0 | 0 |
| DARIOHEALTH CORP | COM NEW | 23725P209 |  | 1403279 | 327869 | SH |  | SOLE |  | 327869 | 0 | 0 |
| DICE THERAPEUTICS INC | COM | 23345J104 |  | 9152894 | 293362 | SH |  | SOLE |  | 293362 | 0 | 0 |
| ENVVENO MEDICAL CORPORATION | COM | 29415J106 |  | 3986236 | 781615 | SH |  | SOLE |  | 781615 | 0 | 0 |
| EQRX INC | *W EXP 12/17/202 | 26886C115 |  | 67050 | 250000 | SH |  | SOLE |  | 250000 | 0 | 0 |
| ESTABLISHMENT LABS HLDGS INC | COM | G31249108 |  | 32684312 | 497857 | SH |  | SOLE |  | 497857 | 0 | 0 |
| HARMONY BIOSCIENCES HLDGS IN | COM | 413197104 |  | 22690400 | 411804 | SH |  | SOLE |  | 411804 | 0 | 0 |
| HILLEVAX INC | COM | 43157M102 |  | 6792782 | 406024 | SH |  | SOLE |  | 406024 | 0 | 0 |
| HORIZON THERAPEUTICS PUB L | SHS | G46188101 |  | 109248000 | 960000 | SH |  | SOLE |  | 960000 | 0 | 0 |
| IMMATICS N.V | SHS | N44445109 |  | 30410965 | 3491500 | SH |  | SOLE |  | 3491500 | 0 | 0 |
| IMMUNOVANT INC | COM | 45258J102 |  | 2662500 | 150000 | SH |  | SOLE |  | 150000 | 0 | 0 |
| INHIBRX INC | COM | 45720L107 |  | 81651613 | 3313783 | SH |  | SOLE |  | 3313783 | 0 | 0 |
| INTUITIVE SURGICAL INC | COM NEW | 46120E602 |  | 10614000 | 40000 | SH |  | SOLE |  | 40000 | 0 | 0 |
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 |  | 63719674 | 9971780 | SH |  | SOLE |  | 9971780 | 0 | 0 |
| ISOPLEXIS CORP | COM | 465005106 |  | 6348021 | 4095498 | SH |  | SOLE |  | 4095498 | 0 | 0 |
| IVERIC BIO INC | COM | 46583P102 |  | 12576234 | 587400 | SH |  | SOLE |  | 587400 | 0 | 0 |
| KRONOS BIO INC | COM | 50107A104 |  | 2839446 | 1752745 | SH |  | SOLE |  | 1752745 | 0 | 0 |
| LANDOS BIOPHARMA INC | COM | 515069102 |  | 7434957 | 14869915 | SH |  | SOLE |  | 14869915 | 0 | 0 |
| LARIMAR THERAPEUTICS INC | COM | 517125100 |  | 11811800 | 2860000 | SH |  | SOLE |  | 2860000 | 0 | 0 |
| LEAP THERAPEUTICS INC | COM | 52187K101 |  | 3026923 | 6726496 | SH |  | SOLE |  | 6726496 | 0 | 0 |
| LIANBIO | SPONSORED ADS | 53000N108 |  | 94395859 | 57558451 | SH |  | SOLE |  | 57558451 | 0 | 0 |
| LYRA THERAPEUTICS INC | COM | 55234L105 |  | 28720732 | 9146730 | SH |  | SOLE |  | 9146730 | 0 | 0 |
| MADRIGAL PHARMACEUTICALS INC | COM | 558868105 |  | 212443263 | 731932 | SH |  | SOLE |  | 731932 | 0 | 0 |
| MADRIGAL PHARMACEUTICALS INC | COM | 558868105 |  | 87075000 | 300000 | SH | Put | SOLE |  | 300000 | 0 | 0 |
| MEIRAGTX HLDGS PLC | COM | G59665102 |  | 45375686 | 6963277 | SH |  | SOLE |  | 6963277 | 0 | 0 |
| MIRATI THERAPEUTICS INC | COM | 60468T105 |  | 99293467 | 2191425 | SH |  | SOLE |  | 2191425 | 0 | 0 |
| MORPHIC HLDG INC | COM | 61775R105 |  | 9715520 | 363197 | SH |  | SOLE |  | 363197 | 0 | 0 |
| MOTUS GI HLDGS INC | COM NEW | 62014P405 |  | 75623 | 90027 | SH |  | SOLE |  | 90027 | 0 | 0 |
| NANOBIOTIX | SPONSORED ADS | 63009J107 |  | 3889466 | 1059800 | SH |  | SOLE |  | 1059800 | 0 | 0 |
| NATERA INC | COM | 632307104 |  | 5222100 | 130000 | SH |  | SOLE |  | 130000 | 0 | 0 |
| NAUTILUS BIOTECHNOLOGY INC | COM | 63909J108 |  | 16400071 | 9111151 | SH |  | SOLE |  | 9111151 | 0 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 |  | 11949972 | 100050 | SH |  | SOLE |  | 100050 | 0 | 0 |
| NEVRO CORP | COM | 64157F103 |  | 1188000 | 30000 | SH |  | SOLE |  | 30000 | 0 | 0 |
| NUVALENT INC | COM | 670703107 |  | 67154108 | 2255007 | SH |  | SOLE |  | 2255007 | 0 | 0 |
| OUTSET MED INC | COM | 690145107 |  | 28129005 | 1089427 | SH |  | SOLE |  | 1089427 | 0 | 0 |
| PEAR THERAPEUTICS INC | CLASS A COM | 704723105 |  | 1062646 | 900548 | SH |  | SOLE |  | 900548 | 0 | 0 |
| PENUMBRA INC | COM | 70975L107 |  | 5650484 | 25400 | SH |  | SOLE |  | 25400 | 0 | 0 |
| POINT BIOPHARMA GLOBAL INC | COM | 730541109 |  | 3645000 | 500000 | SH |  | SOLE |  | 500000 | 0 | 0 |
| PRIVIA HEALTH GROUP INC | COM | 74276R102 |  | 2043900 | 90000 | SH |  | SOLE |  | 90000 | 0 | 0 |
| PROCEPT BIOROBOTICS CORP | COM | 74276L105 |  | 2680867 | 64537 | SH |  | SOLE |  | 64537 | 0 | 0 |
| PROMETHEUS BIOSCIENCES INC | COM | 74349U108 |  | 133396340 | 1212694 | SH |  | SOLE |  | 1212694 | 0 | 0 |
| PROTARA THERAPEUTICS INC | COM STK | 74365U107 |  | 777337 | 290051 | SH |  | SOLE |  | 290051 | 0 | 0 |
| PROTHENA CORP PLC | SHS | G72800108 |  | 14318172 | 237646 | SH |  | SOLE |  | 237646 | 0 | 0 |
| RAIN ONCOLOGY INC | COM | 75082Q105 |  | 19868952 | 2483619 | SH |  | SOLE |  | 2483619 | 0 | 0 |
| RAPT THERAPEUTICS INC | COM | 75382E109 |  | 35619309 | 1798955 | SH |  | SOLE |  | 1798955 | 0 | 0 |
| RELAY THERAPEUTICS INC | COM | 75943R102 |  | 29029869 | 1943097 | SH |  | SOLE |  | 1943097 | 0 | 0 |
| REVANCE THERAPEUTICS INC | COM | 761330109 |  | 13459131 | 729097 | SH |  | SOLE |  | 729097 | 0 | 0 |
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 |  | 21100452 | 1078204 | SH |  | SOLE |  | 1078204 | 0 | 0 |
| ROIVANT SCIENCES LTD | SHS | G76279101 |  | 15832744 | 1981570 | SH |  | SOLE |  | 1981570 | 0 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607100 |  | 84129815 | 649250 | SH |  | SOLE |  | 649250 | 0 | 0 |
| SCPHARMACEUTICALS INC | COM | 810648105 |  | 6828565 | 952380 | SH |  | SOLE |  | 952380 | 0 | 0 |
| SINGULAR GENOMICS SYSTEMS IN | COM | 82933R100 |  | 6597373 | 3282275 | SH |  | SOLE |  | 3282275 | 0 | 0 |
| SOLID BIOSCIENCES INC | COM NEW | 83422E204 |  | 18808120 | 3495933 | SH |  | SOLE |  | 3495933 | 0 | 0 |
| SOMALOGIC INC | CLASS A COM | 83444K105 |  | 3765000 | 1500000 | SH |  | SOLE |  | 1500000 | 0 | 0 |
| SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 |  | 68086143 | 2617691 | SH |  | SOLE |  | 2617691 | 0 | 0 |
| SURROZEN INC | *W EXP 08/01/203 | 86889P117 |  | 9183 | 166666 | SH |  | SOLE |  | 166666 | 0 | 0 |
| TARSUS PHARMACEUTICALS INC | COM | 87650L103 |  | 19005459 | 1296416 | SH |  | SOLE |  | 1296416 | 0 | 0 |
| TRAVERE THERAPEUTICS INC | COM | 89422G107 |  | 1908430 | 90748 | SH |  | SOLE |  | 90748 | 0 | 0 |
| TREACE MEDICAL CONCEPTS INC | COM | 89455T109 |  | 44747805 | 1946403 | SH |  | SOLE |  | 1946403 | 0 | 0 |
| TYRA BIOSCIENCES INC | COM | 90240B106 |  | 3757463 | 494403 | SH |  | SOLE |  | 494403 | 0 | 0 |
| VAXCYTE INC | COM | 92243G108 |  | 56101500 | 1170000 | SH |  | SOLE |  | 1170000 | 0 | 0 |
| VBI VACCINES INC CDA | COM NEW | 91822J103 |  | 20410650 | 52335002 | SH |  | SOLE |  | 52335002 | 0 | 0 |
| VERONA PHARMA PLC | SPONSORED ADS | 925050106 |  | 127533187 | 4880719 | SH |  | SOLE |  | 4880719 | 0 | 0 |
| VERRICA PHARMACEUTICALS INC | COM | 92511W108 |  | 13857203 | 5038983 | SH |  | SOLE |  | 5038983 | 0 | 0 |
| VERU INC | COM | 92536C103 |  | 41490298 | 7858011 | SH |  | SOLE |  | 7858011 | 0 | 0 |
| VIRIDIAN THERAPEUTICS INC | COM | 92790C104 |  | 35652996 | 1220575 | SH |  | SOLE |  | 1220575 | 0 | 0 |
| XENON PHARMACEUTICALS INC | COM | 98420N105 |  | 75755794 | 1921273 | SH |  | SOLE |  | 1921273 | 0 | 0 |
| ZYMEWORKS DEL INC | COM | 98985Y108 |  | 35458621 | 4511275 | SH |  | SOLE |  | 4511275 | 0 | 0 |

---