# EDGAR Filing Document

**Accession Number:** 0001335325
**File Stem:** 0001172661-23-001134
**Filing Date:** 2023-2
**Character Count:** 15275
**Document Hash:** d4cf0abb56671331b9926cf88ebe71ac
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001172661-23-001134.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001172661-23-001134

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**EFFECTIVENESS DATE**: 20230214

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** HighVista Strategies LLC
- **CENTRAL INDEX KEY:** 0001335325
- **IRS NUMBER:** 830423786
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-14212
- **FILM NUMBER:** 23626114

**BUSINESS ADDRESS:**
- **STREET 1:** 200 CLARENDON STREET, 50TH FLOOR
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02116
- **BUSINESS PHONE:** 617-406-6520

**MAIL ADDRESS:**
- **STREET 1:** 200 CLARENDON STREET, 50TH FLOOR
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02116

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2022

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** HighVista Strategies LLC<br>**Address:** 200 CLARENDON STREET 50TH FLOOR<br>BOSTON, MA 02116

**Form 13F File Number:** 028-14212

**CRD Number (if applicable):** 000155759

**SEC File Number (if applicable):** 801-73524

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Ron Landen<br>**Title:** Chief Compliance Officer<br>**Phone:** 617-406-6548

**Signature, Place, and Date of Signing:**

/s/ Ronald A. Landen  Boston, MA  02-14-2023<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 105

**Form 13F Information Table Value Total:** $168454974

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 | BBG001SB06N3 | 901359 | 56618 | SH |  | SOLE |  | 56618 | 0 | 0 |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | BBG003LF0QS8 | 2954999 | 187619 | SH |  | SOLE |  | 187619 | 0 | 0 |
| ACTIVISION BLIZZARD INC | COM | 00507V109 | BBG001S6C009 | 3062000 | 40000 | SH |  | SOLE |  | 40000 | 0 | 0 |
| AKERO THERAPEUTICS INC | COM | 00973Y108 | BBG00L9211Z7 | 1020869 | 18629 | SH |  | SOLE |  | 18629 | 0 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | BBG001S7FTC8 | 963908 | 4056 | SH |  | SOLE |  | 4056 | 0 | 0 |
| ALPHABET INC | CAP STK CL C | 02079K107 | BBG009S3NB21 | 529718 | 5970 | SH |  | SOLE |  | 5970 | 0 | 0 |
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | BBG001SD42R0 | 605823 | 500680 | SH |  | SOLE |  | 500680 | 0 | 0 |
| AMAZON COM INC | COM | 023135106 | BBG001S5PQL7 | 436800 | 5200 | SH |  | SOLE |  | 5200 | 0 | 0 |
| AMICUS THERAPEUTICS INC | COM | 03152W109 | BBG001SN96V9 | 944004 | 77314 | SH |  | SOLE |  | 77314 | 0 | 0 |
| ANAPTYSBIO INC | COM | 032724106 | BBG0026ZDHT8 | 433984 | 14004 | SH |  | SOLE |  | 14004 | 0 | 0 |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 | BBG007KGRPZ3 | 2022430 | 39111 | SH |  | SOLE |  | 39111 | 0 | 0 |
| ARCUS BIOSCIENCES INC | COM | 03969F109 | BBG00DQD2751 | 1481722 | 71650 | SH |  | SOLE |  | 71650 | 0 | 0 |
| ARGENX SE | SPONSORED ADR | 04016X101 | BBG00GHB88Y8 | 883810 | 2333 | SH |  | SOLE |  | 2333 | 0 | 0 |
| ARVINAS INC | COM | 04335A105 | BBG00LW7YL08 | 547155 | 15994 | SH |  | SOLE |  | 15994 | 0 | 0 |
| ASCENDIS PHARMA A/S | SPONSORED ADR | 04351P101 | BBG007R7VP72 | 896190 | 7338 | SH |  | SOLE |  | 7338 | 0 | 0 |
| AUTOLIV INC | COM | 052800109 | BBG001S9YRV6 | 309383 | 4040 | SH |  | SOLE |  | 4040 | 0 | 0 |
| AXSOME THERAPEUTICS INC | COM | 05464T104 | BBG00B6G7GM6 | 4251714 | 55124 | SH |  | SOLE |  | 55124 | 0 | 0 |
| BELLUS HEALTH INC NEW | COM NEW | 07987C204 | BBG001SFH5C0 | 752072 | 91493 | SH |  | SOLE |  | 91493 | 0 | 0 |
| BICYCLE THERAPEUTICS PLC | SPONSORED ADS | 088786108 | BBG00P0YWQ97 | 2736046 | 92434 | SH |  | SOLE |  | 92434 | 0 | 0 |
| BILIBILI INC | SPONS ADS REP Z | 090040106 | BBG00K7T30T9 | 468825 | 19790 | SH |  | SOLE |  | 19790 | 0 | 0 |
| BIOGEN INC | COM | 09062X103 | BBG001S67826 | 759592 | 2743 | SH |  | SOLE |  | 2743 | 0 | 0 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | BBG001S76R05 | 1003956 | 9701 | SH |  | SOLE |  | 9701 | 0 | 0 |
| BIOMEA FUSION INC | COM | 09077A106 | BBG00YS4WDD8 | 1220049 | 144727 | SH |  | SOLE |  | 144727 | 0 | 0 |
| BLACK KNIGHT INC | COM | 09215C105 | BBG00GX77ML3 | 2605850 | 42200 | SH |  | SOLE |  | 42200 | 0 | 0 |
| BLUCORA INC | COM | 095229100 | BBG001S5S9H7 | 323976 | 12690 | SH |  | SOLE |  | 12690 | 0 | 0 |
| CAESARS ENTERTAINMENT INC NE | COM | 12769G100 | BBG0074Q3NL5 | 315328 | 7580 | SH |  | SOLE |  | 7580 | 0 | 0 |
| CATALYST PARTNRS ACQUISITN C | UNIT 99/99/9999 | G19550113 | BBG00ZMGQ3Y0 | 2010000 | 200000 | SH |  | SOLE |  | 200000 | 0 | 0 |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | BBG001S7QN20 | 1102751 | 24742 | SH |  | SOLE |  | 24742 | 0 | 0 |
| CHESAPEAKE ENERGY CORP | COM | 165167735 | BBG00Z6DX607 | 265180 | 2810 | SH |  | SOLE |  | 2810 | 0 | 0 |
| CHINOOK THERAPEUTICS INC | COM | 16961L106 | BBG001T20HH5 | 1296769 | 49495 | SH |  | SOLE |  | 49495 | 0 | 0 |
| CINCOR PHARMA INC | COM | 17240Y109 | BBG00P4V66J1 | 400679 | 32602 | SH |  | SOLE |  | 32602 | 0 | 0 |
| COGENT BIOSCIENCES INC | COM | 19240Q201 | BBG007DHY102 | 2126855 | 183984 | SH |  | SOLE |  | 183984 | 0 | 0 |
| COUPANG INC | CL A | 22266T109 | BBG00XMJRPR7 | 3769643 | 256264 | SH |  | SOLE |  | 256264 | 0 | 0 |
| CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | BBG00BC592C3 | 1718242 | 93893 | SH |  | SOLE |  | 93893 | 0 | 0 |
| CULLINAN ONCOLOGY INC | COM | 230031106 | BBG00HW2DGR3 | 843135 | 79918 | SH |  | SOLE |  | 79918 | 0 | 0 |
| CYMABAY THERAPEUTICS INC | COM | 23257D103 | BBG005NJY3M3 | 2478732 | 395332 | SH |  | SOLE |  | 395332 | 0 | 0 |
| DELL TECHNOLOGIES INC | CL C | 24703L202 | BBG00DW3SZT0 | 14295957 | 355444 | SH |  | SOLE |  | 355444 | 0 | 0 |
| DICE THERAPEUTICS INC | COM | 23345J104 | BBG00WLPGZD1 | 1218797 | 39064 | SH |  | SOLE |  | 39064 | 0 | 0 |
| DINE BRANDS GLOBAL INC | COM | 254423106 | BBG001SD46L7 | 250648 | 3880 | SH |  | SOLE |  | 3880 | 0 | 0 |
| DYNE THERAPEUTICS INC | COM | 26818M108 | BBG00NSGPJF8 | 1187175 | 102431 | SH |  | SOLE |  | 102431 | 0 | 0 |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 | BBG00K4Y2H33 | 1676071 | 187480 | SH |  | SOLE |  | 187480 | 0 | 0 |
| EMCOR GROUP INC | COM | 29084Q100 | BBG001S5QVG1 | 316955 | 2140 | SH |  | SOLE |  | 2140 | 0 | 0 |
| EXPEDIA GROUP INC | COM NEW | 30212P303 | BBG001SP8VM0 | 229512 | 2620 | SH |  | SOLE |  | 2620 | 0 | 0 |
| FATE THERAPEUTICS INC | COM | 31189P102 | BBG001T888S2 | 415647 | 41194 | SH |  | SOLE |  | 41194 | 0 | 0 |
| FIRST HORIZON CORPORATION | COM | 320517105 | BBG001SCW8R8 | 3317300 | 135400 | SH |  | SOLE |  | 135400 | 0 | 0 |
| FISERV INC | COM | 337738108 | BBG001S5R6Q4 | 8684541 | 85926 | SH |  | SOLE |  | 85926 | 0 | 0 |
| GALAPAGOS NV | SPON ADR | 36315X101 | BBG001SC2MJ9 | 918710 | 20701 | SH |  | SOLE |  | 20701 | 0 | 0 |
| GENERATION BIO CO | COM | 37148K100 | BBG00K698K97 | 545798 | 138880 | SH |  | SOLE |  | 138880 | 0 | 0 |
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 | BBG011BQC422 | 637603 | 65597 | SH |  | SOLE |  | 65597 | 0 | 0 |
| GOSSAMER BIO INC | COM | 38341P102 | BBG00MVWLMC1 | 210045 | 96795 | SH |  | SOLE |  | 96795 | 0 | 0 |
| HCA HEALTHCARE INC | COM | 40412C101 | BBG001T8NTY2 | 213565 | 890 | SH |  | SOLE |  | 890 | 0 | 0 |
| IMMUNOCORE HLDGS PLC | ADS | 45258D105 | BBG00YYCXG54 | 752982 | 13194 | SH |  | SOLE |  | 13194 | 0 | 0 |
| INCYTE CORP | COM | 45337C102 | BBG001S8Q6N2 | 873801 | 10879 | SH |  | SOLE |  | 10879 | 0 | 0 |
| INTUIT | COM | 461202103 | BBG001S6TWR2 | 241316 | 620 | SH |  | SOLE |  | 620 | 0 | 0 |
| INVESCO DB COMMDY INDX TRCK | UNIT | 46138B103 | BBG001SNZTS4 | 1045061 | 42396 | SH |  | SOLE |  | 42396 | 0 | 0 |
| ISHARES TR | RUS 1000 VAL ETF | 464287598 | BBG001S562P7 | 3613062 | 23825 | SH |  | SOLE |  | 23825 | 0 | 0 |
| IVERIC BIO INC | COM | 46583P102 | BBG001TG36J3 | 2100193 | 98094 | SH |  | SOLE |  | 98094 | 0 | 0 |
| JD.COM INC | SPON ADR CL A | 47215P106 | BBG005YHY0R6 | 336780 | 6000 | SH |  | SOLE |  | 6000 | 0 | 0 |
| KEROS THERAPEUTICS INC | COM | 492327101 | BBG00H1HP9H8 | 893940 | 18616 | SH |  | SOLE |  | 18616 | 0 | 0 |
| KRYSTAL BIOTECH INC | COM | 501147102 | BBG00HDGRHJ5 | 876015 | 11058 | SH |  | SOLE |  | 11058 | 0 | 0 |
| KURA ONCOLOGY INC | COM | 50127T109 | BBG008974351 | 2036642 | 164113 | SH |  | SOLE |  | 164113 | 0 | 0 |
| LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 | BBG00TTGH6N2 | 809303 | 16212 | SH |  | SOLE |  | 16212 | 0 | 0 |
| LIBERTY GLOBAL PLC | SHS CL A | G5480U104 | BBG001SP2LL9 | 198955 | 10510 | SH |  | SOLE |  | 10510 | 0 | 0 |
| MASONITE INTL CORP | COM | 575385109 | BBG001T51RT2 | 228127 | 2830 | SH |  | SOLE |  | 2830 | 0 | 0 |
| MASTERCARD INCORPORATED | CL A | 57636Q104 | BBG001SKNNS6 | 12933469 | 37194 | SH |  | SOLE |  | 37194 | 0 | 0 |
| MICROSOFT CORP | COM | 594918104 | BBG001S5TD05 | 844166 | 3520 | SH |  | SOLE |  | 3520 | 0 | 0 |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | BBG001SF6HK7 | 530263 | 11703 | SH |  | SOLE |  | 11703 | 0 | 0 |
| MSD ACQUISITION CORP | UNIT 03/25/2026 | G5709C117 | BBG00ZCX69H2 | 5050000 | 500000 | SH |  | SOLE |  | 500000 | 0 | 0 |
| NOAH HLDGS LTD | SPON ADS CL A | 65487X102 | BBG001TCSWD4 | 239320 | 15440 | SH |  | SOLE |  | 15440 | 0 | 0 |
| NOVOCURE LTD | ORD SHS | G6674U108 | BBG009XW8QY0 | 2054313 | 28007 | SH |  | SOLE |  | 28007 | 0 | 0 |
| PAYPAL HLDGS INC | COM | 70450Y103 | BBG0077VNXW5 | 3747454 | 52618 | SH |  | SOLE |  | 52618 | 0 | 0 |
| PENNYMAC FINL SVCS INC NEW | COM | 70932M107 | BBG00LMYX132 | 217575 | 3840 | SH |  | SOLE |  | 3840 | 0 | 0 |
| PLIANT THERAPEUTICS INC | COM | 729139105 | BBG00C8083P2 | 801460 | 41462 | SH |  | SOLE |  | 41462 | 0 | 0 |
| PRIMO WATER CORPORATION | COM | 74167P108 | BBG001S77SH4 | 202952 | 13060 | SH |  | SOLE |  | 13060 | 0 | 0 |
| PROMETHEUS BIOSCIENCES INC | COM | 74349U108 | BBG00PPP6G63 | 2120360 | 19276 | SH |  | SOLE |  | 19276 | 0 | 0 |
| PROTHENA CORP PLC | SHS | G72800108 | BBG00393H6N0 | 877963 | 14572 | SH |  | SOLE |  | 14572 | 0 | 0 |
| PTC INC | COM | 69370C100 | BBG001S6DNK6 | 330110 | 2750 | SH |  | SOLE |  | 2750 | 0 | 0 |
| RELAY THERAPEUTICS INC | COM | 75943R102 | BBG00DSS08L8 | 2637224 | 176521 | SH |  | SOLE |  | 176521 | 0 | 0 |
| RELMADA THERAPEUTICS INC | COM | 75955J402 | BBG003MKSL25 | 91784 | 26299 | SH |  | SOLE |  | 26299 | 0 | 0 |
| REPARE THERAPEUTICS INC | COM | 760273102 | BBG00V5N3XG2 | 2425532 | 164890 | SH |  | SOLE |  | 164890 | 0 | 0 |
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | BBG007DLZ629 | 1033119 | 35478 | SH |  | SOLE |  | 35478 | 0 | 0 |
| SALESFORCE INC | COM | 79466L302 | BBG001SDLP09 | 300979 | 2270 | SH |  | SOLE |  | 2270 | 0 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607100 | BBG001S6KJC6 | 999451 | 7713 | SH |  | SOLE |  | 7713 | 0 | 0 |
| SEAGEN INC | COM | 81181C104 | BBG001S9M4Q6 | 828632 | 6448 | SH |  | SOLE |  | 6448 | 0 | 0 |
| SERVICENOW INC | COM | 81762P102 | BBG001T4JFC0 | 291202 | 750 | SH |  | SOLE |  | 750 | 0 | 0 |
| SOUTH JERSEY INDS INC | COM | 838518108 | BBG001S5W3G6 | 2824635 | 79500 | SH |  | SOLE |  | 79500 | 0 | 0 |
| SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | BBG00Q011TX8 | 905226 | 34803 | SH |  | SOLE |  | 34803 | 0 | 0 |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | BBG001T92272 | 474922 | 18661 | SH |  | SOLE |  | 18661 | 0 | 0 |
| TEGNA INC | COM | 87901J105 | BBG001S5RHD4 | 3051360 | 144000 | SH |  | SOLE |  | 144000 | 0 | 0 |
| TERNS PHARMACEUTICALS INC | COM | 880881107 | BBG00KK1SJ17 | 787362 | 77344 | SH |  | SOLE |  | 77344 | 0 | 0 |
| THIRD HARMONIC BIO INC | COM | 88427A107 | BBG00Z14GXC9 | 394654 | 91780 | SH |  | SOLE |  | 91780 | 0 | 0 |
| TJX COS INC NEW | COM | 872540109 | BBG001S5WQ93 | 210144 | 2640 | SH |  | SOLE |  | 2640 | 0 | 0 |
| T-MOBILE US INC | COM | 872590104 | BBG001SKR9Y6 | 257600 | 1840 | SH |  | SOLE |  | 1840 | 0 | 0 |
| TRANSDIGM GROUP INC | COM | 893641100 | BBG001SPV1C1 | 508128 | 807 | SH |  | SOLE |  | 807 | 0 | 0 |
| TRAVERE THERAPEUTICS INC | COM | 89422G107 | BBG001SL72C5 | 2562169 | 121834 | SH |  | SOLE |  | 121834 | 0 | 0 |
| UNITED THERAPEUTICS CORP DEL | COM | 91307C102 | BBG001S8RV10 | 891000 | 3204 | SH |  | SOLE |  | 3204 | 0 | 0 |
| VAXCYTE INC | COM | 92243G108 | BBG009PHHPP4 | 940108 | 19606 | SH |  | SOLE |  | 19606 | 0 | 0 |
| VENTYX BIOSCIENCES INC | COM | 92332V107 | BBG00VC84K47 | 1090464 | 33256 | SH |  | SOLE |  | 33256 | 0 | 0 |
| VERONA PHARMA PLC | SPONSORED ADS | 925050106 | BBG00GD4KBM0 | 1794896 | 68691 | SH |  | SOLE |  | 68691 | 0 | 0 |
| VERVE THERAPEUTICS INC | COM | 92539P101 | BBG00P33TD13 | 688860 | 35600 | SH |  | SOLE |  | 35600 | 0 | 0 |
| VIRIDIAN THERAPEUTICS INC | COM | 92790C104 | BBG002H24301 | 2920474 | 99982 | SH |  | SOLE |  | 99982 | 0 | 0 |
| VISA INC | COM CL A | 92826C839 | BBG001SRCFY3 | 8832916 | 42515 | SH |  | SOLE |  | 42515 | 0 | 0 |
| VMWARE INC | CL A COM | 928563402 | BBG001S6TFZ0 | 2897136 | 23600 | SH |  | SOLE |  | 23600 | 0 | 0 |
| WILLIS TOWERS WATSON PLC LTD | SHS | G96629103 | BBG001SHY2Q9 | 298387 | 1220 | SH |  | SOLE |  | 1220 | 0 | 0 |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | BBG002VBMLS5 | 999156 | 25340 | SH |  | SOLE |  | 25340 | 0 | 0 |

---