# EDGAR Filing Document

**Accession Number:** 0001383496
**File Stem:** 0000940400-25-002083
**Filing Date:** 2025-9
**Character Count:** 29396
**Document Hash:** 5faa026d442e7b4d37b4685a1dae9bd0
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000940400-25-002083.hdr.sgml**: 20250924

**ACCESSION NUMBER**: 0000940400-25-002083

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20250731

**FILED AS OF DATE**: 20250924

**DATE AS OF CHANGE**: 20250924

**PERIOD START**: 20250731

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** FIRST TRUST EXCHANGE-TRADED ALPHADEX FUND
- **CENTRAL INDEX KEY:** 0001383496

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** MA

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-22019
- **FILM NUMBER:** 251336245

**BUSINESS ADDRESS:**
- **STREET 1:** 120 EAST LIBERTY DRIVE, SUITE 400
- **CITY:** WHEATON
- **STATE:** IL
- **ZIP:** 60187
- **BUSINESS PHONE:** 630-765-8000

**MAIL ADDRESS:**
- **STREET 1:** 120 EAST LIBERTY DRIVE, SUITE 400
- **CITY:** WHEATON
- **STATE:** IL
- **ZIP:** 60187

## Series and Classes Contracts Data

### First Trust Health Care AlphaDEX Fund (Series ID: S000017700)

| Class ID   | Class Name                            | Ticker Symbol   |
|:---|:---|:---|
| C000048900 | First Trust Health Care AlphaDEX Fund | FXH             |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** First Trust Exchange-Traded AlphaDEX Fund

- **b. Investment Company Act file number:** 811-22019

- **c. CIK number of Registrant:** 0001383496

- **d. LEI of Registrant:** 549300PGRVU1P76W4537

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 120 East Liberty Drive

  - **City:** Wheaton

  - **State:** IL

  - **Foreign country:** US

  - **Zip / Postal Code:** 60187

  - **Telephone number:** 630-765-8000

**Item A.2. Information about the Series.**

- **a. Name of Series:** First Trust Health Care AlphaDEX Fund

- **b. EDGAR series identifier (if any):** S000017700

- **c. LEI of Series:** 5493009VIGFPXQC5HK94

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2025-07-31

- **b. Date as of which information is reported:** 2025-07-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $864963959.35

**Total Liabilities:** $19513656.43

**Net Assets:** $845450302.92

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000048900 | 1.00%                | 2.00%                | -4.74%               |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $2049704.73              | $6170803.55                                |
| Month 2  | $3920249.25              | $13806336.10                               |
| Month 3  | $10871434.01             | $-53167675.63                              |

### Schedule of Portfolio Investments

| Name                               | Title                             | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Zoetis Inc                         | Zoetis Inc                        | CUSIP: 98978V103<br>LEI: 549300HD9Q1LOC9KLJ48 | Long             | EC               | CORP              | US        |     23704 | NS      | $3455806.16   | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| United Therapeutics Corp           | United Therapeutics Corp          | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |     68614 | NS      | $18848265.80  | 2.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Tenet Healthcare Corp              | Tenet Healthcare Corp             | CUSIP: 88033G407<br>LEI: 0W9AIBT6U6ADJ2I8HK17 | Long             | EC               | CORP              | US        |     67214 | NS      | $10840273.92  | 1.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Halozyme Therapeutics Inc          | Halozyme Therapeutics Inc         | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |     71063 | NS      | $4261648.11   | 0.50%             |  |  |  | No            |                  1 | On Loan: No      |
| BOFA SECURITIES, INC.              | BOFA SECURITIES INC               | CUSIP: 000000000<br>LEI: 549300HN4UKV1E2R3U73 | Long             | RA               | CORP              | US        |   5309060 | PA      | $5309060.00   | 0.63%             |  |  |  | No            |                  2 | On Loan: No      |
| Royalty Pharma PLC                 | Royalty Pharma PLC                | CUSIP: 000000000<br>LEI: 549300FGFN7VOK8BZR03 | Long             | EC               | CORP              | US        |    328329 | NS      | $12082507.20  | 1.43%             |  |  |  | No            |                  1 | On Loan: No      |
| Amgen Inc                          | Amgen Inc                         | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |     13242 | NS      | $3907714.20   | 0.46%             |  |  |  | No            |                  1 | On Loan: No      |
| HCA Healthcare Inc                 | HCA Healthcare Inc                | CUSIP: 40412C101<br>LEI: 529900PH4ZGUH2MNEU89 | Long             | EC               | CORP              | US        |     41171 | NS      | $14574122.29  | 1.72%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen Inc                         | Biogen Inc                        | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |    156989 | NS      | $20094592.00  | 2.38%             |  |  |  | No            |                  1 | On Loan: No      |
| Johnson & Johnson                  | Johnson & Johnson                 | CUSIP: 478160104<br>LEI: 549300G0CFPGEF6X2043 | Long             | EC               | CORP              | US        |    103260 | NS      | $17011052.40  | 2.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Exelixis Inc                       | Exelixis Inc                      | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |    447332 | NS      | $16202365.04  | 1.92%             |  |  |  | No            |                  1 | On Loan: No      |
| Centene Corp                       | Centene Corp                      | CUSIP: 15135B101<br>LEI: 549300Z7JJ4TQSQGT333 | Long             | EC               | CORP              | US        |    363231 | NS      | $9469432.17   | 1.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Waters Corp                        | Waters Corp                       | CUSIP: 941848103<br>LEI: 5T547R1474YC9HOD8Q74 | Long             | EC               | CORP              | US        |     10591 | NS      | $3058257.16   | 0.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Pfizer Inc                         | Pfizer Inc                        | CUSIP: 717081103<br>LEI: 765LHXWGK1KXCLTFYQ30 | Long             | EC               | CORP              | US        |    650699 | NS      | $15154779.71  | 1.79%             |  |  |  | No            |                  1 | On Loan: No      |
| Molina Healthcare Inc              | Molina Healthcare Inc             | CUSIP: 60855R100<br>LEI: 549300NQQCEQ46YHZ591 | Long             | EC               | CORP              | US        |     39711 | NS      | $6269175.57   | 0.74%             |  |  |  | No            |                  1 | On Loan: No      |
| BioMarin Pharmaceutical Inc        | BioMarin Pharmaceutical Inc       | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |    286937 | NS      | $16599305.45  | 1.96%             |  |  |  | No            |                  1 | On Loan: No      |
| MIZUHO SECURITIES USA LLC          | MIZUHO SECURITIES USA LLC         | CUSIP: 000000000<br>LEI: 7TK5RJIZDFROZCA6XF66 | Long             | RA               | CORP              | US        |   5146859 | PA      | $5146859.00   | 0.61%             |  |  |  | No            |                  2 | On Loan: No      |
| Revvity Inc                        | Revvity Inc                       | CUSIP: 714046109<br>LEI: 549300IKL1SDPFI7N655 | Long             | EC               | CORP              | US        |     81539 | NS      | $7167278.10   | 0.85%             |  |  |  | No            |                  1 | On Loan: No      |
| GE HealthCare Technologies Inc     | GE HealthCare Technologies Inc    | CUSIP: 36266G107<br>LEI: 549300OI9J7XOWZMUN85 | Long             | EC               | CORP              | US        |    159710 | NS      | $11390517.20  | 1.35%             |  |  |  | No            |                  1 | On Loan: No      |
| IDEXX Laboratories Inc             | IDEXX Laboratories Inc            | CUSIP: 45168D104<br>LEI: OGMTXK0LUU1HKV2P0J84 | Long             | EC               | CORP              | US        |     22056 | NS      | $11784741.36  | 1.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Cooper Cos Inc/The                 | Cooper Cos Inc/The                | CUSIP: 216648501<br>LEI: QJKMVPIGLH7530PCUE20 | Long             | EC               | CORP              | US        |    110828 | NS      | $7834431.32   | 0.93%             |  |  |  | No            |                  1 | On Loan: No      |
| DaVita Inc                         | DaVita Inc                        | CUSIP: 23918K108<br>LEI: M2XHYMU3TZNEZURC6H66 | Long             | EC               | CORP              | US        |     25951 | NS      | $3642741.87   | 0.43%             |  |  |  | No            |                  1 | On Loan: No      |
| Henry Schein Inc                   | Henry Schein Inc                  | CUSIP: 806407102<br>LEI: VGO3WGL8H45T73F4RR92 | Long             | EC               | CORP              | US        |    107961 | NS      | $7303561.65   | 0.86%             |  |  |  | No            |                  1 | On Loan: No      |
| Avantor Inc                        | Avantor Inc                       | CUSIP: 05352A100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1464797 | NS      | $19686871.68  | 2.33%             |  |  |  | No            |                  1 | On Loan: No      |
| Danaher Corp                       | Danaher Corp                      | CUSIP: 235851102<br>LEI: S4BKK9OTCEWQ3YHPFM11 | Long             | EC               | CORP              | US        |     18716 | NS      | $3690046.56   | 0.44%             |  |  |  | No            |                  1 | On Loan: No      |
| Regeneron Pharmaceuticals Inc      | Regeneron Pharmaceuticals Inc     | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |     37553 | NS      | $20483659.38  | 2.42%             |  |  |  | No            |                  1 | On Loan: No      |
| Cardinal Health Inc                | Cardinal Health Inc               | CUSIP: 14149Y108<br>LEI: CCU46N3GJMF4OK4N7U60 | Long             | EC               | CORP              | US        |    117359 | NS      | $18216463.98  | 2.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Labcorp Holdings Inc               | Labcorp Holdings Inc              | CUSIP: 504922105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     30042 | NS      | $7813323.36   | 0.92%             |  |  |  | No            |                  1 | On Loan: No      |
| Acadia Healthcare Co Inc           | Acadia Healthcare Co Inc          | CUSIP: 00404A109<br>LEI: 5493005CW985Y9D0NC11 | Long             | EC               | CORP              | US        |    868937 | NS      | $18916758.49  | 2.24%             |  |  |  | No            |                  1 | On Loan: No      |
| MSILF Treasury Portfolio           | MSILF Treasury Portfolio          | CUSIP: 61747C582<br>LEI: 549300D1XR6GP7EZ0T47 | Long             | STIV             | RF                | US        |   1607838 | NS      | $1607837.98   | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences Inc         | Neurocrine Biosciences Inc        | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |     29412 | NS      | $3771500.76   | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Perrigo Co PLC                     | Perrigo Co PLC                    | CUSIP: 000000000<br>LEI: 549300IFOQS6R1QLY196 | Long             | EC               | CORP              | IE        |    138353 | NS      | $3689874.51   | 0.44%             |  |  |  | No            |                  1 | On Loan: No      |
| Chemed Corp                        | Chemed Corp                       | CUSIP: 16359R103<br>LEI: 54930020031IDJT2IM79 | Long             | EC               | CORP              | US        |     16196 | NS      | $6677610.80   | 0.79%             |  |  |  | No            |                  1 | On Loan: No      |
| Abbott Laboratories                | Abbott Laboratories               | CUSIP: 002824100<br>LEI: HQD377W2YR662HK5JX27 | Long             | EC               | CORP              | US        |    115969 | NS      | $14634128.11  | 1.73%             |  |  |  | No            |                  1 | On Loan: No      |
| Becton Dickinson & Co              | Becton Dickinson & Co             | CUSIP: 075887109<br>LEI: ICE2EP6D98PQUILVRZ91 | Long             | EC               | CORP              | US        |     45784 | NS      | $8160998.00   | 0.97%             |  |  |  | No            |                  1 | On Loan: No      |
| Zimmer Biomet Holdings Inc         | Zimmer Biomet Holdings Inc        | CUSIP: 98956P102<br>LEI: 2P2YLDVPES3BXQ1FRB91 | Long             | EC               | CORP              | US        |    216163 | NS      | $19811338.95  | 2.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Gilead Sciences Inc                | Gilead Sciences Inc               | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |    106699 | NS      | $11981230.71  | 1.42%             |  |  |  | No            |                  1 | On Loan: No      |
| Jazz Pharmaceuticals PLC           | Jazz Pharmaceuticals PLC          | CUSIP: 000000000<br>LEI: 635400GAUMJCLEZRRV50 | Long             | EC               | CORP              | IE        |    185792 | NS      | $21297336.96  | 2.52%             |  |  |  | No            |                  1 | On Loan: No      |
| Thermo Fisher Scientific Inc       | Thermo Fisher Scientific Inc      | CUSIP: 883556102<br>LEI: HCHV7422L5HDJZCRFL38 | Long             | EC               | CORP              | US        |     19450 | NS      | $9096376.00   | 1.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Universal Health Services Inc      | Universal Health Services Inc     | CUSIP: 913903100<br>LEI: 549300YGMGQDO0NMJD09 | Long             | EC               | CORP              | US        |    108840 | NS      | $18116418.00  | 2.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Solventum Corp                     | Solventum Corp                    | CUSIP: 83444M101<br>LEI: 254900I70403OSGY4M28 | Long             | EC               | CORP              | US        |     48744 | NS      | $3478371.84   | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals Inc        | Alnylam Pharmaceuticals Inc       | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |     48369 | NS      | $18972256.56  | 2.24%             |  |  |  | No            |                  1 | On Loan: No      |
| J.P. MORGAN SECURITIES LLC         | JP MORGAN SECURITIES LLC          | CUSIP: 000000000<br>LEI: ZBUT11V806EZRVTWT807 | Long             | RA               | CORP              | US        |   7280725 | PA      | $7280725.00   | 0.86%             |  |  |  | No            |                  2 | On Loan: No      |
| Elevance Health Inc                | Elevance Health Inc               | CUSIP: 036752103<br>LEI: 8MYN82XMYQH89CTMTH67 | Long             | EC               | CORP              | US        |     40552 | NS      | $11479460.16  | 1.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Cigna Group/The                    | Cigna Group/The                   | CUSIP: 125523100<br>LEI: 549300VIWYMSIGT1U456 | Long             | EC               | CORP              | US        |     47713 | NS      | $12757501.94  | 1.51%             |  |  |  | No            |                  1 | On Loan: No      |
| Medtronic PLC                      | Medtronic PLC                     | CUSIP: 000000000<br>LEI: 549300GX3ZBSQWUXY261 | Long             | EC               | CORP              | IE        |    135707 | NS      | $12246199.68  | 1.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Organon & Co                       | Organon & Co                      | CUSIP: 68622V106<br>LEI: 549300AMCKY57OK2CO56 | Long             | EC               | CORP              | US        |   1629435 | NS      | $15805519.50  | 1.87%             |  |  |  | No            |                  1 | On Loan: No      |
| Incyte Corp                        | Incyte Corp                       | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |    173710 | NS      | $13009141.90  | 1.54%             |  |  |  | No            |                  1 | On Loan: No      |
| Dexcom Inc                         | Dexcom Inc                        | CUSIP: 252131107<br>LEI: 549300YSK3QDSFR5EU59 | Long             | EC               | CORP              | US        |     42350 | NS      | $3420609.50   | 0.40%             |  |  |  | No            |                  1 | On Loan: No      |
| ResMed Inc                         | ResMed Inc                        | CUSIP: 761152107<br>LEI: 529900T3QE5253CCXF22 | Long             | EC               | CORP              | US        |     45852 | NS      | $12468992.88  | 1.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Align Technology Inc               | Align Technology Inc              | CUSIP: 016255101<br>LEI: 549300N5YSE0U3LCP840 | Long             | EC               | CORP              | US        |     19526 | NS      | $2519049.26   | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Agilent Technologies Inc           | Agilent Technologies Inc          | CUSIP: 00846U101<br>LEI: QUIX8Y7A2WP0XRMW7G29 | Long             | EC               | CORP              | US        |     31327 | NS      | $3596652.87   | 0.43%             |  |  |  | No            |                  1 | On Loan: No      |
| Bristol-Myers Squibb Co            | Bristol-Myers Squibb Co           | CUSIP: 110122108<br>LEI: HLYYNH7UQUORYSJQCN42 | Long             | EC               | CORP              | US        |    255558 | NS      | $11068216.98  | 1.31%             |  |  |  | No            |                  1 | On Loan: No      |
| UnitedHealth Group Inc             | UnitedHealth Group Inc            | CUSIP: 91324P102<br>LEI: 549300GHBMY8T5GXDE41 | Long             | EC               | CORP              | US        |     50558 | NS      | $12617254.48  | 1.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Natera Inc                         | Natera Inc                        | CUSIP: 632307104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     93364 | NS      | $12479032.24  | 1.48%             |  |  |  | No            |                  1 | On Loan: No      |
| Veeva Systems Inc                  | Veeva Systems Inc                 | CUSIP: 922475108<br>LEI: 549300YZEXPDB92M2F02 | Long             | EC               | CORP              | US        |     54772 | NS      | $15566202.40  | 1.84%             |  |  |  | No            |                  1 | On Loan: No      |
| Masimo Corp                        | Masimo Corp                       | CUSIP: 574795100<br>LEI: 549300Q4A8JK0PIYCU29 | Long             | EC               | CORP              | US        |     46882 | NS      | $7209982.78   | 0.85%             |  |  |  | No            |                  1 | On Loan: No      |
| Summit Therapeutics Inc            | Summit Therapeutics Inc           | CUSIP: 86627T108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    173721 | NS      | $4581022.77   | 0.54%             |  |  |  | No            |                  1 | On Loan: —       |
| STERIS PLC                         | STERIS PLC                        | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     15389 | NS      | $3485454.61   | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| IQVIA Holdings Inc                 | IQVIA Holdings Inc                | CUSIP: 46266C105<br>LEI: 549300W3R20NM4KQPH86 | Long             | EC               | CORP              | US        |     50043 | NS      | $9300991.98   | 1.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Doximity Inc                       | Doximity Inc                      | CUSIP: 26622P107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    192854 | NS      | $11330172.50  | 1.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Quest Diagnostics Inc              | Quest Diagnostics Inc             | CUSIP: 74834L100<br>LEI: 8MCWUBXQ0WE04KMXBX50 | Long             | EC               | CORP              | US        |     65856 | NS      | $11024952.96  | 1.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Intuitive Surgical Inc             | Intuitive Surgical Inc            | CUSIP: 46120E602<br>LEI: 54930052SRG011710797 | Long             | EC               | CORP              | US        |     14513 | NS      | $6982059.17   | 0.83%             |  |  |  | No            |                  1 | On Loan: No      |
| Insulet Corp                       | Insulet Corp                      | CUSIP: 45784P101<br>LEI: 549300TZTYD2PYN92D43 | Long             | EC               | CORP              | US        |     50202 | NS      | $14478256.80  | 1.71%             |  |  |  | No            |                  1 | On Loan: No      |
| Encompass Health Corp              | Encompass Health Corp             | CUSIP: 29261A100<br>LEI: 549300FVRPM9DRQZRG64 | Long             | EC               | CORP              | US        |     64311 | NS      | $7081284.21   | 0.84%             |  |  |  | No            |                  1 | On Loan: No      |
| Insmed Inc                         | Insmed Inc                        | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |    195907 | NS      | $21016902.96  | 2.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Elanco Animal Health Inc           | Elanco Animal Health Inc          | CUSIP: 28414H103<br>LEI: 549300SHPNDCE059M934 | Long             | EC               | CORP              | US        |   1380684 | NS      | $18887757.12  | 2.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Exact Sciences Corp                | Exact Sciences Corp               | CUSIP: 30063P105<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |    222613 | NS      | $10451680.35  | 1.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Humana Inc                         | Humana Inc                        | CUSIP: 444859102<br>LEI: 529900YLDW34GJAO4J06 | Long             | EC               | CORP              | US        |     64517 | NS      | $16120862.79  | 1.91%             |  |  |  | No            |                  1 | On Loan: No      |
| West Pharmaceutical Services I     | West Pharmaceutical Services Inc  | CUSIP: 955306105<br>LEI: 5493007NKRGM1RJQ1P16 | Long             | EC               | CORP              | US        |     16895 | NS      | $4042297.70   | 0.48%             |  |  |  | No            |                  1 | On Loan: No      |
| DAIWA CAPITAL MARKETS AMERICA INC. | DAIWA CAPITAL MARKETS AMERICA INC | CUSIP: 000000000<br>LEI: M67H5PRC0NQKM73ZAS82 | Long             | RA               | CORP              | US        |   1099070 | PA      | $1099070.00   | 0.13%             |  |  |  | No            |                  2 | On Loan: No      |
| Globus Medical Inc                 | Globus Medical Inc                | CUSIP: 379577208<br>LEI: 5299003M2P4CIK0RF205 | Long             | EC               | CORP              | US        |    133625 | NS      | $7032683.75   | 0.83%             |  |  |  | No            |                  1 | On Loan: No      |
| Hologic Inc                        | Hologic Inc                       | CUSIP: 436440101<br>LEI: 549300DYP6F5ZJL0LB74 | Long             | EC               | CORP              | US        |    121032 | NS      | $8087358.24   | 0.96%             |  |  |  | No            |                  1 | On Loan: No      |
| Merck & Co Inc                     | Merck & Co Inc                    | CUSIP: 58933Y105<br>LEI: 4YV9Y5M8S0BRK1RP0397 | Long             | EC               | CORP              | US        |    249066 | NS      | $19457035.92  | 2.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Boston Scientific Corp             | Boston Scientific Corp            | CUSIP: 101137107<br>LEI: Y6ZDD9FP4P8JSSJMW954 | Long             | EC               | CORP              | US        |    146847 | NS      | $15407187.24  | 1.82%             |  |  |  | No            |                  1 | On Loan: No      |
| Stryker Corp                       | Stryker Corp                      | CUSIP: 863667101<br>LEI: 5493002F0SC4JTBU5137 | Long             | EC               | CORP              | US        |     19933 | NS      | $7828287.09   | 0.93%             |  |  |  | No            |                  1 | On Loan: No      |
| Corcept Therapeutics Inc           | Corcept Therapeutics Inc          | CUSIP: 218352102<br>LEI: 529900EO9LUTFMZ7FF90 | Long             | EC               | CORP              | US        |    161168 | NS      | $10825654.56  | 1.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Teleflex Inc                       | Teleflex Inc                      | CUSIP: 879369106<br>LEI: UUL85LWXB4NGSWWXIQ25 | Long             | EC               | CORP              | US        |     99948 | NS      | $11943786.00  | 1.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Tempus AI Inc                      | Tempus AI Inc                     | CUSIP: 88023B103<br>LEI: 2549009LA0KWRAGQBX50 | Long             | EC               | CORP              | US        |    310294 | NS      | $17559537.46  | 2.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Edwards Lifesciences Corp          | Edwards Lifesciences Corp         | CUSIP: 28176E108<br>LEI: YA13X31F3V31L8TMPR58 | Long             | EC               | CORP              | US        |     47269 | NS      | $3748904.39   | 0.44%             |  |  |  | No            |                  1 | On Loan: No      |
| Penumbra Inc                       | Penumbra Inc                      | CUSIP: 70975L107<br>LEI: 549300RGE06P3ECANU72 | Long             | EC               | CORP              | US        |     30730 | NS      | $7752257.10   | 0.92%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2025-09-23

**Name of Applicant:** First Trust Exchange-Traded AlphaDEX Fund

**Signature:** Derek Maltbie

**Name of Signer:** Derek Maltbie

**Title:** Treasurer, Chief Financial Officer and Chief Accounting Officer