# EDGAR Filing Document

**Accession Number:** 0001628171
**File Stem:** 0001193125-26-071987
**Filing Date:** 2026-2
**Character Count:** 23295
**Document Hash:** e05b6e6732cf5012e7bccaedf9ec09bc
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-26-071987.hdr.sgml**: 20260225

**ACCESSION NUMBER**: 0001193125-26-071987

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 16

**FILED AS OF DATE**: 20260225

**DATE AS OF CHANGE**: 20260225

**EFFECTIVENESS DATE**: 20260225

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Revolution Medicines, Inc.
- **CENTRAL INDEX KEY:** 0001628171
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 472029180
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-293757
- **FILM NUMBER:** 26679889

**BUSINESS ADDRESS:**
- **STREET 1:** 700 SAGINAW DR
- **CITY:** REDWOOD CITY
- **STATE:** CA
- **ZIP:** 94063
- **BUSINESS PHONE:** 650-481-6801

**MAIL ADDRESS:**
- **STREET 1:** 700 SAGINAW DR
- **CITY:** REDWOOD CITY
- **STATE:** CA
- **ZIP:** 94063

**As filed with the Securities and Exchange Commission on February 25, 2026** 

**Registration No. 333-**

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**Washington, D.C. 20549** 

**FORM S-8** 

**REGISTRATION STATEMENT** 

***UNDER***

***THE SECURITIES ACT OF 1933***

## Revolution Medicines, Inc.
**(Exact name of registrant as specified in its charter)** 

---

| | |
|:---|:---|
| **Delaware** | **47-2029180** |
| **(State or other jurisdiction of**<br> **incorporation or organization)** | **(I.R.S. Employer**<br> **Identification No.)** |
| **700 Saginaw Drive**<br> **Redwood City, California** | **94063** |
| **(Address of Principal Executive Offices)** | **(Zip Code)** |

---

**2020 Incentive Award Plan** 

**2020 Employee Stock Purchase Plan** 

**(Full Title of the plan)** 

**Mark A. Goldsmith, M.D., Ph.D.** 

**President and Chief Executive Officer** 

**Revolution Medicines, Inc.** 

**700 Saginaw Drive** 

**Redwood City, California 94063** 

**(650) 481-6801** 

**(Name, address, including zip code, and telephone number, including area code, of agent for service)** 

***Copies to:***

**Mark V. Roeder, Esq.** 

**John C. Williams, Esq.** 

**Zuzanna V. Gruca, Esq.** 

**Latham & Watkins LLP** 

**140 Scott Drive** 

**Menlo Park, California 94025** 

**(650) 328-4600** 

Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☒ | Accelerated filer | ☐ |
| Non-accelerated filer | ☐ | Smaller reporting company | ☐ |
|  |  | Emerging growth company | ☐ |

---

If an emerging growth company, indicate by check mark if the Registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

------

**PART I** 

**INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS** 

The information called for in Part I of Form S-8 is not being filed with or included in this Form S-8 (by incorporation by reference or otherwise) in accordance with the rules and regulations of the Securities and Exchange Commission (the "Commission"). The documents containing the information specified in Part I of Form S-8 will be delivered to the participants in the equity benefit plans covered by this Registration Statement as specified by Rule 428(b)(1) under the Securities Act.

**PART II** 

**INFORMATION REQUIRED IN THE REGISTRATION STATEMENT** 

*In this Registration Statement, Revolution Medicines, Inc. is sometimes referred to as "Registrant."* 

**REGISTRATION OF ADDITIONAL SECURITIES** 

**PURSUANT TO GENERAL INSTRUCTION E OF FORM S-8** 

This Registration Statement on Form S-8 (the "Registration Statement") is filed by the Registrant, relating to (a) 9,850,070 shares of its common stock, $0.0001 par value (the "Common Stock"), issuable to eligible employees, directors and consultants of the Registrant under the Registrant's 2020 Incentive Award Plan (the "2020 Plan") and (b) 1,970,014 shares of Common Stock issuable to eligible employees of the Registrant under the 2020 Employee Stock Purchase Plan (the "ESPP"). Shares available for issuance under the 2020 Plan and the ESPP were previously registered on registration statements on Form S-8 filed with the Commission on February 18, 2020, Registration No.[<u>333-236493</u>](http://www.sec.gov/Archives/edgar/data/0001628171/000119312520040586/d848168ds8.htm), March 2, 2021, Registration No.[<u>333-253791</u>](http://www.sec.gov/Archives/edgar/data/0001628171/000119312521065619/d132542ds8.htm), February 28, 2022, Registration No.[<u>333-263098</u>](http://www.sec.gov/Archives/edgar/data/1628171/000119312522058203/d273100ds8.htm), February 27, 2023, Registration No.[<u>333-270065</u>](http://www.sec.gov/Archives/edgar/data/1628171/000119312523050923/d438138ds8.htm), February 26, 2024, Registration No.[<u>333-277368</u>](http://www.sec.gov/Archives/edgar/data/1628171/000119312524046297/d780941ds8.htm), and February 26, 2025, Registration No.[<u>333-285285</u>](http://www.sec.gov/Archives/edgar/data/1628171/000119312525036828/d930835ds8.htm)<u> </u>(the "Prior Registration Statements"). The Prior Registration Statements are currently effective. This Registration Statement relates to securities of the same class as those to which the Prior Registration Statements relate and is submitted in accordance with Section E of the General Instructions to Form S-8 regarding Registration of Additional Securities. Pursuant to Section E of the General Instructions to Form S-8, the contents of the Prior Registration Statements are incorporated herein by reference and made part of this Registration Statement, except as amended hereby.

**Item 3.** **Incorporation of Documents by Reference.** <br>

The following documents filed with the Commission by the Registrant are incorporated by reference into this Registration Statement:

• the Registrant's Annual Report on [Form 10-K](http://www.sec.gov/Archives/edgar/data/../../../ix?doc=/Archives/edgar/data/1628171/000119312526071563/rvmd-20251231.htm) for the year ended December 31, 2025, filed with the Commission on February 25, 2026;

• the description of the Registrant's Common Stock that is registered under Section 12 of the Exchange
Act, in the Registrant's registration statement on [<u>Form 8-A</u>](http://www.sec.gov/Archives/edgar/data/1628171/000119312520026836/d881796d8a12b.htm) , filed on February 6, 2020,
including any amendments or reports filed for the purpose of updating such description.

------

All documents that the Registrant subsequently files pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the filing of a post-effective amendment to the Registration Statement that indicates that all of the shares of Common Stock registered hereunder have been sold or that deregisters all of such shares then remaining unsold, shall be deemed to be incorporated by reference in this Registration Statement and to be a part hereof from the date of the filing of such documents; except as to any portion of any future annual or quarterly report to stockholders or document or Current Report on Form 8-K furnished under Items 2.02 or 7.01, and exhibits furnished on such form that relate to such items, that is not deemed filed under such provisions. For the purposes of this Registration Statement, any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded to the extent that a statement contained herein or in any other subsequently filed document that also is or is deemed to be incorporated by reference herein modifies or supersedes such earlier statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.

Under no circumstances will any information furnished under Items 2.02 or 7.01 of any Current Report on Form 8-K, and exhibits furnished on such form that relate to such items, be deemed incorporated herein by reference unless such Form 8-K expressly provides to the contrary.

**Item 5.** **Interests of Named Experts and Counsel.** <br>

Certain attorneys affiliated with Latham & Watkins LLP own shares of the Registrant's Common Stock representing in the aggregate less than 1% of the outstanding shares of the Registrant's Common Stock.

**Item 8.** **Exhibits.** <br>

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| **Exhibit**<br> **Number** | | **Incorporated by Reference** | **Incorporated by Reference** | **Incorporated by Reference** | **Filed**<br> **Herewith** |
| **Exhibit**<br> **Number** | <br>**Exhibit Description** | **Form** | **Date** | **Number** | **Filed**<br> **Herewith** |
| &nbsp;&nbsp;&nbsp;&nbsp;4.1 | [Amended and Restated Certificate of Incorporation.](http://www.sec.gov/Archives/edgar/data/1628171/000119312520040328/d848154dex31.htm) | 8-K | 2/18/2020 | 3.1 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;4.2 | [Amended and Restated Bylaws.](http://www.sec.gov/Archives/edgar/data/1628171/000119312521073330/d144671dex31.htm) | 8-K | 3/8/2021 | 3.1 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;4.3 | [Form of Common Stock Certificate.](http://www.sec.gov/Archives/edgar/data/1628171/000119312520010145/d799036dex42.htm) | S-1 | 1/17/2020 | 4.2 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;5.1 | [Opinion of Latham & Watkins LLP.](d71067dex51.htm) |  |  |  | X |
| 23.1 | [Consent of Independent Registered Public Accounting Firm.](d71067dex231.htm) |  |  |  | X |
| 23.2 | [Consent of Latham & Watkins LLP (included in Exhibit 5.1).](d71067dex51.htm) |  |  |  | X |
| 24.1 | [Power of Attorney. Reference is made to the signature page to the Registration Statement.](#sig) |  |  |  | X |
| 99.1# | [2020 Incentive Award Plan.](http://www.sec.gov/Archives/edgar/data/1628171/000119312520022117/d799036dex107a.htm) | S-1/A | 2/3/2020 | 10.7 (a) |  |
| 99.2# | [2020 Employee Stock Purchase Plan.](http://www.sec.gov/Archives/edgar/data/1628171/000119312520022117/d799036dex108.htm) | S-1/A | 2/3/2020 | 10.8 |  |
| 107.1 | [Filing Fee Table.](d71067dexfilingfees.htm) |  |  |  | X |

---

# Indicates management contract or compensatory plan.

------

**SIGNATURES** 

Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in Redwood City, California, on this 25th day of February, 2026.

---

| | |
|:---|:---|
| **Revolution Medicines, Inc.** | **Revolution Medicines, Inc.** |
| By: | /s/ Mark A. Goldsmith |
|  | Mark A. Goldsmith, M.D., Ph.D. |
|  | *President and Chief Executive Officer* |

---

**POWER OF ATTORNEY** 

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Mark A. Goldsmith, M.D., Ph.D., Jeff Cislini and Jack Anders, and each of them acting individually, as his or her true and lawful attorneys-in-fact and agents, each with full power of substitution, for him or her in any and all capacities, to sign any and all amendments to this Registration Statement, including post-effective amendments or any abbreviated registration statement and any amendments thereto filed pursuant to Rule 462(b) increasing the number of securities for which registration is sought, and to file the same, with all exhibits thereto and other documents in connection therewith, with the Commission, granting unto said attorneys-in-fact and agents, with full power of each to act alone, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or his or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

------

---

| | | |
|:---|:---|:---|
| **Signature** | **Title** | **Date** |
| /s/ Mark A. Goldsmith<br> Mark A. Goldsmith, M.D., Ph.D. | President, Chief Executive Officer and Director<br> *(Principal Executive Officer)* | February 25, 2026 |
| /s/ Jack Anders<br> Jack Anders | Chief Financial Officer<br> *(Principal Financial and Accounting Officer)* | February 25, 2026 |
| /s/ Elizabeth McKee Anderson<br> Elizabeth McKee Anderson | Director | February 25, 2026 |
| /s/ Flavia Borellini<br> Flavia Borellini, Ph.D. | Director | February 25, 2026 |
| /s/ Alexis Borisy<br> Alexis Borisy | Director | February 25, 2026 |
| /s/ Frank Clyburn<br> Frank Clyburn | Director | February 25, 2026 |
| /s/ Sandra J. Horning<br> Sandra J. Horning, M.D. | Director | February 25, 2026 |
| /s/ Lorence Kim<br> Lorence Kim, M.D. | Director | February 25, 2026 |
| /s/ Sushil Patel<br> Sushil Patel, Ph.D. | Director | February 25, 2026 |
| /s/ Thilo Schroeder<br> Thilo Schroeder, Ph.D. | Director | February 25, 2026 |

---

## Exhibit 5.1

**Exhibit 5.1** 

---

| | | |
|:---|:---|:---|
|  | 140 Scott Drive | 140 Scott Drive |
|  | Menlo Park, California 94025 | Menlo Park, California 94025 |
|  | Tel: +1.650.328.4600 Fax: +1.650.463.2600 | Tel: +1.650.328.4600 Fax: +1.650.463.2600 |
|  | <br> www.lw.com | <br> www.lw.com |
| ![LOGO](g71067dsp07.jpg) | FIRM / AFFILIATE OFFICES | FIRM / AFFILIATE OFFICES |
| ![LOGO](g71067dsp07.jpg) | Austin | Milan |
| ![LOGO](g71067dsp07.jpg) | Beijing | Munich |
| ![LOGO](g71067dsp07.jpg) | Boston | New York |
| ![LOGO](g71067dsp07.jpg) | Brussels | Orange County |
| ![LOGO](g71067dsp07.jpg) | Chicago | Paris |
|  | Dubai | Riyadh |
| February 25, 2026 | Düsseldorf | San Diego |
|  | Frankfurt | San Francisco |
|  | Hamburg | Seoul |
|  | Hong Kong | Silicon Valley |
|  | Houston | Singapore |
|  | London | Tel Aviv |
|  | Los Angeles | Tokyo |
|  | Madrid | Washington, D.C. |

---

Revolution Medicines, Inc.

700 Saginaw Drive

Redwood City, CA 94063

---

| | |
|:---|:---|
| Re: | Registration Statement on Form S-8; 11,820,084 shares of Common Stock of Revolution Medicines, Inc., par value $0.0001 per share  |

---

To the addressee set forth above:

We have acted as special counsel to Revolution Medicines, Inc., a Delaware corporation (the "***Company***"), in connection with the registration by the Company of an aggregate of 11,820,084 shares of common stock of the Company, par value $0.0001 per share (the "***Shares***"), issuable under the Company's 2020 Incentive Award Plan (the "***2020 Plan***") and 2020 Employee Stock Purchase Plan (the "***ESPP***" and together with the 2020 Plan, the "***Plans***").

The Shares are included in a registration statement on Form S-8 under the Securities Act of 1933, as amended (the "***Act***"), filed with the Securities and Exchange Commission (the "***Commission***") on February 25, 2026 (the "***Registration Statement***"). This opinion is being furnished in connection with the requirements of Item 601(b)(5) of Regulation S-K under the Act, and no opinion is expressed herein as to any matter pertaining to the contents of the Registration Statement or the related prospectuses, other than as expressly stated herein with respect to the issuance of the Shares.

As such counsel, we have examined such matters of fact and questions of law as we have considered appropriate for purposes of this letter. With your consent, we have relied upon certificates and other assurances of officers of the Company and others as to factual matters without having independently verified such factual matters. We are opining herein as to the General Corporation Law of the State of Delaware (the "***DGCL***"), and we express no opinion with respect to any other laws.

Subject to the foregoing and the other matters set forth herein, it is our opinion that, as of the date hereof, when the Shares shall have been duly registered on the books of the transfer agent and registrar therefor in the name or on behalf of the purchasers and have been issued by the Company for legal consideration not less than par value in the circumstances contemplated by the

------

 **February 25, 2026** 

**Page 2**![LOGO](g71067dsp08.jpg)

Plans, assuming in each case that the individual issuances, grants or awards under the Plans are duly authorized by all necessary corporate action of the Company and duly issued, granted or awarded and exercised in accordance with the requirements of law and the Plans (and the agreements and awards duly adopted thereunder and in accordance therewith), the issuance and sale of the Shares will have been duly authorized by all necessary corporate action of the Company, and the Shares will be validly issued, fully paid and nonassessable. In rendering the foregoing opinion, we have assumed that the Company will comply with all applicable notice requirements regarding uncertificated shares provided in the DGCL.

This opinion is for your benefit in connection with the Registration Statement and may be relied upon by you and by persons entitled to rely upon it pursuant to the applicable provisions of the Act. We consent to your filing this opinion as an exhibit to the Registration Statement. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Act or the rules and regulations of the Commission thereunder.

---

| |
|:---|
| Sincerely, |
| **/s**/ Latham & Watkins LLP |

---

## Exhibit 23.1

**Exhibit 23.1** 

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in this Registration Statement on Form S-8 of Revolution Medicines, Inc. of our report dated February 25, 2026 relating to the financial statements and the effectiveness of internal control over financial reporting, which appears in Revolution Medicines, Inc.'s Annual Report on Form 10-K for the year ended December 31, 2025.

/s/ PricewaterhouseCoopers LLP

San Jose, California

February 25, 2026

## Ex-Filing

?xml version='1.0' encoding='ASCII'? EX-FILING FEES

---

| |
|:---|
| **Calculation of Filing Fee Tables**  |
| &nbsp;&nbsp;&nbsp;&nbsp;**S-8**  |
| &nbsp;&nbsp;&nbsp;&nbsp;**Revolution Medicines, Inc.**  |

---

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| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | **Security Type**  | **Security Class Title**  | **Fee Calculation Rule**  | **Amount Registered**  | **Proposed Maximum Offering Price Per Unit**  | **Maximum Aggregate Offering Price**  | **Fee Rate**  | **Amount of Registration Fee**  |
| 1 | Equity | Common stock, $0.0001 par value per share | Other | 9850070 | $101.51 | $999880605.70 | 0.0001381 | $138083.51 |
| 2 | Equity | Common stock, $0.0001 par value per share | Other | 1970014 | $86.28 | $169972807.92 | 0.0001381 | $23473.24 |
| Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: |  | $1169853413.62  |  | $161556.75  |
| Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  |  |  |  | $0.00  |
| Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  |  |  |  | $161556.75  |

---

 **Offering Note** <br>

<sup>1</sup> (1) Pursuant to Rule 416 of the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement shall also cover any additional shares of the Registrant's Common Stock ("Common Stock") that become issuable under the Registrant's 2020 Incentive Award Plan (the "2020 Plan") and the Registrant's 2020 Employee Stock Purchase Plan (the "ESPP") by reason of any stock dividend, stock split or similar transaction effected without the receipt of consideration that results in an increase in the number of the outstanding shares of Common Stock. (2) Represents shares of Common Stock that were automatically added to the shares authorized for issuance under the 2020 Plan on January 1, 2026 pursuant to an "evergreen" provision contained in the 2020 Plan. Pursuant to such provision, the number of shares of Common Stock reserved for issuance pursuant to awards under such plan is increased on the first day of each year beginning in 2021 and ending in 2030 equal to the lesser of (A) five percent of the shares of stock outstanding on the last day of the immediately preceding fiscal year and (B) such smaller number of shares of stock as determined by the Registrant's board of directors. (3) Estimated in accordance with Rule 457(c) and (h) solely for the purpose of calculating the registration fee on the basis of $101.51 per share, which is the average of the high and low prices of Common Stock on February 20, 2026, as reported on the Nasdaq Global Select Market.

<sup>2</sup> (1) Pursuant to Rule 416 of the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement shall also cover any additional shares of the Registrant's Common Stock ("Common Stock") that become issuable under the Registrant's 2020 Incentive Award Plan (the "2020 Plan") and the Registrant's 2020 Employee Stock Purchase Plan (the "ESPP") by reason of any stock dividend, stock split or similar transaction effected without the receipt of consideration that results in an increase in the number of the outstanding shares of Common Stock. (4) Represents shares of Common Stock that were automatically added to the shares authorized for issuance under the ESPP on January 1, 2026 pursuant to an "evergreen" provision contained in the ESPP. Pursuant to such provision, the number of shares of Common Stock reserved for issuance under such plan is increased on the first day of each year beginning in 2021 and ending in 2030 equal to the lesser of (A) one percent of the shares of stock outstanding on the last day of the immediately preceding fiscal year and (B) such smaller number of shares of stock as determined by the Registrant's board of directors. (5) Estimated in accordance with Rule 457(c) and (h) solely for the purpose of calculating the registration fee on the basis of 85% of $101.51 per share, which is the average of the high and low prices of Common Stock on February 20, 2026, as reported on the Nasdaq Global Select Market. Pursuant to the ESPP, the purchase price of the shares of Common Stock reserved for issuance thereunder will be at least 85% of the lesser of the fair market value of the Registrant's Common Stock on the first trading day of the offering period or on the last trading day of each purchase period.

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| | |
|:---|:---|
| | |
| **Rule 457(p)** | **Rule 457(p)** |
| Fee Offset Claims | N/A |
| Fee Offset Sources | N/A |

---