# EDGAR Filing Document

**Accession Number:** 0001587114
**File Stem:** 0000935836-23-000229
**Filing Date:** 2023-2
**Character Count:** 10587
**Document Hash:** c4791485a11eb745447c688e853538dc
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000935836-23-000229.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0000935836-23-000229

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**EFFECTIVENESS DATE**: 20230214

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** EcoR1 Capital, LLC
- **CENTRAL INDEX KEY:** 0001587114
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-16764
- **FILM NUMBER:** 23625178

**BUSINESS ADDRESS:**
- **STREET 1:** 357 TEHAMA STREET #3
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94103
- **BUSINESS PHONE:** 415-448-6534

**MAIL ADDRESS:**
- **STREET 1:** 357 TEHAMA STREET #3
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94103

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2022

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** EcoR1 Capital LLC<br>**Address:** 357 Tehama Street #3<br>San Francisco, CA 94103

**Form 13F File Number:** 028-16764

**CRD Number (if applicable):** 000167121

**SEC File Number (if applicable):** 801-100470

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Oleg Nodelman<br>**Title:** Manager<br>**Phone:** 415-448-6534

**Signature, Place, and Date of Signing:**

/s/ Oleg Nodelman  San Francisco, CA  02-14-2023<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 66

**Form 13F Information Table Value Total:** $3285596936

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| 2SEVENTY BIO INC | COMMON STOCK | 901384107 |  | 10714539 | 1143494 | SH |  | SOLE |  | 1143494 | 0 | 0 |
| ABEONA THERAPEUTICS INC | COM NEW | 00289Y206 |  | 3347824 | 1086956 | SH |  | SOLE |  | 1086956 | 0 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 |  | 95384346 | 5991479 | SH |  | SOLE |  | 5991479 | 0 | 0 |
| ADICET BIO INC | COM | 007002108 |  | 31832658 | 3560700 | SH |  | SOLE |  | 3560700 | 0 | 0 |
| ALECTOR INC | COM | 014442107 |  | 37441938 | 4056548 | SH |  | SOLE |  | 4056548 | 0 | 0 |
| ALIGOS THERAPEUTICS INC | COM | 01626L105 |  | 3762392 | 3948360 | SH |  | SOLE |  | 3948360 | 0 | 0 |
| ALLOGENE THERAPEUTICS INC | COM | 019770106 |  | 28230778 | 4488200 | SH |  | SOLE |  | 4488200 | 0 | 0 |
| ANAPTYSBIO INC | COM | 032724106 |  | 233076534 | 7521024 | SH |  | SOLE |  | 7521024 | 0 | 0 |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 |  | 268035217 | 5183431 | SH |  | SOLE |  | 5183431 | 0 | 0 |
| ARCUTIS BIOTHERAPEUTICS INC | COM | 03969K108 |  | 6146766 | 415322 | SH |  | SOLE |  | 415322 | 0 | 0 |
| ARVINAS INC | COM | 04335A105 |  | 106848093 | 3123300 | SH |  | SOLE |  | 3123300 | 0 | 0 |
| ARYA SCIENCES ACQU CORP IV | CL A | G31659108 |  | 1515000 | 150000 | SH |  | SOLE |  | 150000 | 0 | 0 |
| ATEA PHARMACEUTICALS INC | COM | 04683R106 |  | 29749181 | 6184861 | SH |  | SOLE |  | 6184861 | 0 | 0 |
| AVEO PHARMACEUTICALS INC | COM NEW | 053588307 |  | 9724811 | 650489 | SH |  | SOLE |  | 650489 | 0 | 0 |
| BIOATLA INC | COM | 09077B104 |  | 9276622 | 1124439 | SH |  | SOLE |  | 1124439 | 0 | 0 |
| BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 |  | 507836 | 282131 | SH |  | SOLE |  | 282131 | 0 | 0 |
| CAREMAX INC | *W EXP 06/08/202 | 14171W111 |  | 365000 | 100000 | SH |  | SOLE |  | 100000 | 0 | 0 |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 |  | 16220065 | 5232279 | SH |  | SOLE |  | 5232279 | 0 | 0 |
| CHINOOK THERAPEUTICS INC | COM | 16961L106 |  | 18078000 | 690000 | SH |  | SOLE |  | 690000 | 0 | 0 |
| CRINETICS PHARMACEUTICALS IN | COM | 22663K107 |  | 24343813 | 1330263 | SH |  | SOLE |  | 1330263 | 0 | 0 |
| CULLINAN ONCOLOGY INC | COM | 230031106 |  | 10919651 | 1035038 | SH |  | SOLE |  | 1035038 | 0 | 0 |
| DESIGN THERAPEUTICS INC | COM | 25056L103 |  | 9079105 | 884903 | SH |  | SOLE |  | 884903 | 0 | 0 |
| DYNE THERAPEUTICS INC | COM | 26818M108 |  | 26916431 | 2322384 | SH |  | SOLE |  | 2322384 | 0 | 0 |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 |  | 31229154 | 3493194 | SH |  | SOLE |  | 3493194 | 0 | 0 |
| ERASCA INC | COM | 29479A108 |  | 2924081 | 678441 | SH |  | SOLE |  | 678441 | 0 | 0 |
| EUCRATES BIOMEDICAL ACQU COR | *W EXP 10/23/202 | G3141W122 |  | 665993 | 66666 | SH |  | SOLE |  | 66666 | 0 | 0 |
| EUCRATES BIOMEDICAL ACQU COR | SHS | G3141W106 |  | 1998000 | 200000 | SH |  | SOLE |  | 200000 | 0 | 0 |
| GALAPAGOS NV | SPON ADR | 36315X101 |  | 165569797 | 3730730 | SH |  | SOLE |  | 3730730 | 0 | 0 |
| GERON CORP | COM | 374163103 |  | 9748987 | 4028507 | SH |  | SOLE |  | 4028507 | 0 | 0 |
| GRACELL BIOTECHNOLOGIES INC | SPONSORED ADS | 38406L103 |  | 7689365 | 3343202 | SH |  | SOLE |  | 3343202 | 0 | 0 |
| GRAPHITE BIO INC | COM | 38870X104 |  | 18964159 | 5712096 | SH |  | SOLE |  | 5712096 | 0 | 0 |
| HEALTH SCIENCES ACQ CORP 2 | ORD SHS | G4411D109 |  | 3992000 | 400000 | SH |  | SOLE |  | 400000 | 0 | 0 |
| HOOKIPA PHARMA INC | COM | 43906K100 |  | 2003526 | 2473489 | SH |  | SOLE |  | 2473489 | 0 | 0 |
| IMMATICS N.V | SHS | N44445109 |  | 6471530 | 743000 | SH |  | SOLE |  | 743000 | 0 | 0 |
| ITEOS THERAPEUTICS INC | COM | 46565G104 |  | 790574 | 40480 | SH |  | SOLE |  | 40480 | 0 | 0 |
| JANUX THERAPEUTICS INC | COM | 47103J105 |  | 18718771 | 1421319 | SH |  | SOLE |  | 1421319 | 0 | 0 |
| KRONOS BIO INC | COM | 50107A104 |  | 529384 | 326780 | SH |  | SOLE |  | 326780 | 0 | 0 |
| KURA ONCOLOGY INC | COM | 50127T109 |  | 82382184 | 6638371 | SH |  | SOLE |  | 6638371 | 0 | 0 |
| KYMERA THERAPEUTICS INC | COM | 501575104 |  | 19870481 | 796093 | SH |  | SOLE |  | 796093 | 0 | 0 |
| MACROGENICS INC | COM | 556099109 |  | 7498123 | 1117455 | SH |  | SOLE |  | 1117455 | 0 | 0 |
| MORPHIC HLDG INC | COM | 61775R105 |  | 105704391 | 3951566 | SH |  | SOLE |  | 3951566 | 0 | 0 |
| NEWAMSTERDAM PHARMA COMPANY | *W EXP 11/22/202  ADDED | N62509117 |  | 726649 | 66665 | SH |  | SOLE |  | 66665 | 0 | 0 |
| NGM BIOPHARMACEUTICALS INC | COM | 62921N105 |  | 32306300 | 6435518 | SH |  | SOLE |  | 6435518 | 0 | 0 |
| NUVATION BIO INC | *W EXP 07/07/202 | 67080N119 |  | 1849599 | 963333 | SH |  | SOLE |  | 963333 | 0 | 0 |
| NUVATION BIO INC | COM CL A | 67080N101 |  | 26681363 | 13896543 | SH |  | SOLE |  | 13896543 | 0 | 0 |
| ORIC PHARMACEUTICALS INC | COM | 68622P109 |  | 20132421 | 3418068 | SH |  | SOLE |  | 3418068 | 0 | 0 |
| OVID THERAPEUTICS INC | COM | 690469101 |  | 11378364 | 6117400 | SH |  | SOLE |  | 6117400 | 0 | 0 |
| POSEIDA THERAPEUTICS INC | COM | 73730P108 |  | 14045000 | 2650000 | SH |  | SOLE |  | 2650000 | 0 | 0 |
| PRAXIS PRECISION MEDICINES I | COM | 74006W108 |  | 3773071 | 1585324 | SH |  | SOLE |  | 1585324 | 0 | 0 |
| PRECISION BIOSCIENCES INC | COM | 74019P108 |  | 5992805 | 5035971 | SH |  | SOLE |  | 5035971 | 0 | 0 |
| PRIME MEDICINE INC | COM  ADDED | 74168J101 |  | 11148000 | 600000 | SH |  | SOLE |  | 600000 | 0 | 0 |
| PROTHENA CORP PLC | SHS | G72800108 |  | 697952870 | 11584280 | SH |  | SOLE |  | 11584280 | 0 | 0 |
| RELAY THERAPEUTICS INC | COM | 75943R102 |  | 62207531 | 4163824 | SH |  | SOLE |  | 4163824 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 106206972 | 4458731 | SH |  | SOLE |  | 4458731 | 0 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607100 |  | 388669120 | 2999453 | SH |  | SOLE |  | 2999453 | 0 | 0 |
| SELECTA BIOSCIENCES INC | COM | 816212104 |  | 3955000 | 3500000 | SH |  | SOLE |  | 3500000 | 0 | 0 |
| SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 |  | 90000010 | 3460208 | SH |  | SOLE |  | 3460208 | 0 | 0 |
| SURFACE ONCOLOGY INC | COM | 86877M209 |  | 3218265 | 3924713 | SH |  | SOLE |  | 3924713 | 0 | 0 |
| SURROZEN INC | *W EXP 08/01/203 | 86889P117 |  | 38792 | 66665 | SH |  | SOLE |  | 66665 | 0 | 0 |
| TANGO THERAPEUTICS INC | COM | 87583X109 |  | 30460252 | 4201414 | SH |  | SOLE |  | 4201414 | 0 | 0 |
| TEMPEST THERAPEUTICS INC | COM | 87978U108 |  | 1185958 | 1031268 | SH |  | SOLE |  | 1031268 | 0 | 0 |
| VENTYX BIOSCIENCES INC | COM | 92332V107 |  | 13116000 | 400000 | SH |  | SOLE |  | 400000 | 0 | 0 |
| VOYAGER THERAPEUTICS INC | COM | 92915B106 |  | 28998833 | 4753907 | SH |  | SOLE |  | 4753907 | 0 | 0 |
| XENCOR INC | COM | 98401F105 |  | 137556717 | 5282516 | SH |  | SOLE |  | 5282516 | 0 | 0 |
| ZAI LAB LTD | ADR | 98887Q104 |  | 66240960 | 2157686 | SH |  | SOLE |  | 2157686 | 0 | 0 |
| ZYMEWORKS DEL INC | COM  ADDED | 98985Y108 |  | 59488984 | 7568573 | SH |  | SOLE |  | 7568573 | 0 | 0 |

---