# EDGAR Filing Document

**Accession Number:** 0001039803
**File Stem:** 0000910472-26-001921
**Filing Date:** 2026-2
**Character Count:** 54892
**Document Hash:** 272102a0384d0a44ca9f2bc6e12b1dba
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000910472-26-001921.hdr.sgml**: 20260219

**ACCESSION NUMBER**: 0000910472-26-001921

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20251231

**FILED AS OF DATE**: 20260219

**DATE AS OF CHANGE**: 20260219

**PERIOD START**: 20251231

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** ProFunds
- **CENTRAL INDEX KEY:** 0001039803

**ORGANIZATION NAME:**
- **EIN:** 522035197
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-08239
- **FILM NUMBER:** 26652797

**BUSINESS ADDRESS:**
- **STREET 1:** 7272 WISCONSIN AVENUE
- **STREET 2:** 21ST FLOOR
- **CITY:** BETHESDA
- **STATE:** MD
- **ZIP:** 20814
- **BUSINESS PHONE:** 2404976428

**MAIL ADDRESS:**
- **STREET 1:** 7272 WISCONSIN AVENUE
- **STREET 2:** 21ST FLOOR
- **CITY:** BETHESDA
- **STATE:** MD
- **ZIP:** 20814

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** PROFUNDS
- **DATE OF NAME CHANGE:** 19970521

## Series and Classes Contracts Data

### PROFUND VP BIOTECHNOLOGY (Series ID: S000003965)

| Class ID   | Class Name               | Ticker Symbol   |
|:---|:---|:---|
| C000011092 | PROFUND VP BIOTECHNOLOGY |  |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** ProFunds

- **b. Investment Company Act file number:** 811-08239

- **c. CIK number of Registrant:** 0001039803

- **d. LEI of Registrant:** 549300HM4OOUYSE5DP77

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 7272 Wisconsin Avenue

  - **City:** Bethesda

  - **State:** MD

  - **Foreign country:** US

  - **Zip / Postal Code:** 20814

  - **Telephone number:** 240-497-6400

**Item A.2. Information about the Series.**

- **a. Name of Series:** PROFUND VP BIOTECHNOLOGY

- **b. EDGAR series identifier (if any):** S000003965

- **c. LEI of Series:** G74DJGSGIKRN0SEEG418

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2025-12-31

- **b. Date as of which information is reported:** 2025-12-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $43003895.17

**Total Liabilities:** $1826755.85

**Net Assets:** $41177139.32

**Cash Not Reported:** $63311.79

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000011092 | 12.52%               | 9.15%                | -0.78%               |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $193393.34               | $3960804.20                                |
| Month 2  | $289392.13               | $3083496.47                                |
| Month 3  | $3456682.76              | $-3644547.86                               |

**Designated Index Information**

- **Index Name:** Dow Jones U.S. Biotechnology Index

- **Index Identifier:** DJUSBT

### Schedule of Portfolio Investments

| Name                                | Title                                         | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Adma Biologics Inc                  | ADMA Biologics, Inc.                          | CUSIP: 000899104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     25225 | NS      | $460104.00    | 1.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Absci Corp.                         | Absci Corporation                             | CUSIP: 00091E109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     17745 | NS      | $61930.05     | 0.15%             |  |  |  | No            |                  1 | On Loan: —       |
| AbbVie Inc.                         | AbbVie, Inc.                                  | CUSIP: 00287Y109<br>LEI: FR5LCKFTG8054YNNRU85 | Long             | EC               | CORP              | US        |      2238 | NS      | $511360.62    | 1.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Acadia Pharmaceuticals Inc          | ACADIA Pharmaceuticals, Inc.                  | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |     17176 | NS      | $458770.96    | 1.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Invivyd Inc                         | Invivyd, Inc.                                 | CUSIP: 00534A102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     24653 | NS      | $60892.91     | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Spyre Therapeutics Inc              | Spyre Therapeutics, Inc.                      | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |      4627 | NS      | $151580.52    | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Agios Pharmaceuticals Inc           | Agios Pharmaceuticals, Inc.                   | CUSIP: 00847X104<br>LEI: 529900ONJHY8EOGYT555 | Long             | EC               | CORP              | US        |      9312 | NS      | $253472.64    | 0.62%             |  |  |  | No            |                  1 | On Loan: No      |
| Akebia Therapeutics Inc.            | Akebia Therapeutics, Inc.                     | CUSIP: 00972D105<br>LEI: 549300CBQEHMKEEGNX42 | Long             | EC               | CORP              | US        |     43198 | NS      | $69548.78     | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals Inc.        | Alnylam Pharmaceuticals, Inc.                 | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |      1246 | NS      | $495471.90    | 1.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Altimmune Inc.                      | Altimmune, Inc.                               | CUSIP: 02155H200<br>LEI: 549300EOYCQ8SW3NVE64 | Long             | EC               | CORP              | US        |     16960 | NS      | $61225.60     | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Amgen Inc.                          | Amgen, Inc.                                   | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |      1598 | NS      | $523041.38    | 1.27%             |  |  |  | No            |                  1 | On Loan: No      |
| Amicus Therapeutics Inc.            | Amicus Therapeutics, Inc.                     | CUSIP: 03152W109<br>LEI: 549300MRD1SMUTNBPQ53 | Long             | EC               | CORP              | US        |     42719 | NS      | $608318.56    | 1.48%             |  |  |  | No            |                  1 | On Loan: No      |
| AnaptysBio Inc.                     | AnaptysBio, Inc.                              | CUSIP: 032724106<br>LEI: 529900HH4WQT03IG1A12 | Long             | EC               | CORP              | US        |      3059 | NS      | $148300.32    | 0.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Anavex Life Sciences Corp.          | Anavex Life Sciences Corporation              | CUSIP: 032797300<br>LEI: 549300K1I5L8COCQ8W36 | Long             | EC               | CORP              | US        |     13541 | NS      | $48205.96     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Annexon Inc                         | Annexon, Inc.                                 | CUSIP: 03589W102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     12271 | NS      | $61600.42     | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Apellis Pharmaceuticals Inc         | Apellis Pharmaceuticals, Inc.                 | CUSIP: 03753U106<br>LEI: 254900HS0ZFRXXSB9D42 | Long             | EC               | CORP              | US        |     14854 | NS      | $373132.48    | 0.91%             |  |  |  | No            |                  1 | On Loan: No      |
| Apogee Therapeutics Inc.            | Apogee Therapeutics, Inc.                     | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4212 | NS      | $317921.76    | 0.77%             |  |  |  | No            |                  1 | On Loan: No      |
| Arbutus Biopharma Corp.             | Arbutus Biopharma Corporation                 | CUSIP: 03879J100<br>LEI: 25490064CESONAUIAS23 | Long             | EC               | CORP              | US        |     10139 | NS      | $48768.59     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcellx Inc                         | Arcellx, Inc.                                 | CUSIP: 03940C100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6022 | NS      | $392634.40    | 0.95%             |  |  |  | No            |                  1 | On Loan: No      |
| Ardelyx Inc                         | Ardelyx, Inc.                                 | CUSIP: 039697107<br>LEI: 549300F542QR4SXHCY32 | Long             | EC               | CORP              | US        |     33806 | NS      | $197088.98    | 0.48%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcus Biosciences Inc.              | Arcus Biosciences, Inc.                       | CUSIP: 03969F109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8051 | NS      | $191855.33    | 0.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcutis Biotherapeutics Inc.        | Arcutis Biotherapeutics, Inc.                 | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     14907 | NS      | $432899.28    | 1.05%             |  |  |  | No            |                  1 | On Loan: No      |
| ArriVent BioPharma Inc.             | ArriVent Biopharma, Inc.                      | CUSIP: 04272N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2502 | NS      | $50340.24     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Arrowhead Pharmaceuticals Inc       | Arrowhead Pharmaceuticals, Inc.               | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |      7318 | NS      | $485842.02    | 1.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Avidity Biosciences Inc.            | Avidity Biosciences, Inc.                     | CUSIP: 05370A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7064 | NS      | $509526.32    | 1.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Bicara Therapeutics Inc.            | Bicara Therapeutics, Inc.                     | CUSIP: 055477103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5182 | NS      | $87213.06     | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Beam Therapeutics Inc.              | Beam Therapeutics, Inc.                       | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     15322 | NS      | $424725.84    | 1.03%             |  |  |  | No            |                  1 | On Loan: No      |
| BioCryst Pharmaceuticals  Inc.      | BioCryst Pharmaceuticals, Inc.                | CUSIP: 09058V103<br>LEI: 549300Z0INP1Z5NP6J59 | Long             | EC               | CORP              | US        |     33143 | NS      | $258515.40    | 0.63%             |  |  |  | No            |                  1 | On Loan: No      |
| Biomarin Pharmaceutical Inc.        | BioMarin Pharmaceutical, Inc.                 | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |      9385 | NS      | $557750.55    | 1.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen Inc                          | Biogen, Inc.                                  | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |      2839 | NS      | $499635.61    | 1.21%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                 | VPBT_SPSIBI_GOLDMAN                           | CUSIP: N/A<br>LEI: N/A                        | Long             | DE               |  | US        |       106 | OU      | $-24772.62    | -0.06%            |  |  |  | No            |                  2 | On Loan: No      |
| N/A                                 | VPBT_SPSIBI_GOLDMAN                           | CUSIP: N/A<br>LEI: N/A                        | Short            | DE               |  | US        |       -76 | OU      | $3772.43      | 0.01%             |  |  |  | No            |                  2 | On Loan: No      |
| Bridgebio Pharma Inc                | Bridgebio Pharma, Inc.                        | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |      6932 | NS      | $530228.68    | 1.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Caredx Inc                          | CareDx, Inc.                                  | CUSIP: 14167L103<br>LEI: 549300NQOFKL9NON0U06 | Long             | EC               | CORP              | US        |      7895 | NS      | $148741.80    | 0.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Catalyst Pharmaceuticals Inc.       | Catalyst Pharmaceuticals, Inc.                | CUSIP: 14888U101<br>LEI: 5299004O0R5XXLA5H544 | Long             | EC               | CORP              | US        |     13432 | NS      | $313502.88    | 0.76%             |  |  |  | No            |                  1 | On Loan: No      |
| Celcuity Inc.                       | Celcuity, Inc.                                | CUSIP: 15102K100<br>LEI: 25490070W7UU7W2SEY87 | Long             | EC               | CORP              | US        |      4949 | NS      | $493613.26    | 1.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Celldex Therapeutics Inc.           | Celldex Therapeutics, Inc.                    | CUSIP: 15117B202<br>LEI: 529900F018DMYWH38923 | Long             | EC               | CORP              | US        |      9896 | NS      | $268775.36    | 0.65%             |  |  |  | No            |                  1 | On Loan: No      |
| CG Oncology Inc.                    | CG oncology, Inc.                             | CUSIP: 156944100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      9188 | NS      | $381485.76    | 0.93%             |  |  |  | No            |                  1 | On Loan: No      |
| Cidara Therapeutics Inc             | Cidara Therapeutics, Inc.                     | CUSIP: 171757206<br>LEI: 549300IHQ9Z7RI1X2D22 | Long             | EC               | CORP              | US        |      2295 | NS      | $506942.55    | 1.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Cogent Biosciences Inc.             | Cogent Biosciences, Inc.                      | CUSIP: 19240Q201<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      9625 | NS      | $341880.00    | 0.83%             |  |  |  | No            |                  1 | On Loan: No      |
| Compass Therapeutics Inc            | Compass Therapeutics, Inc.                    | CUSIP: 20454B104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     13146 | NS      | $70594.02     | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Corvus Pharmaceuticals Inc          | Corvus Pharmaceuticals, Inc.                  | CUSIP: 221015100<br>LEI: 549300I3AVJ8F75NCX65 | Long             | EC               | CORP              | US        |      8640 | NS      | $66528.00     | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Cullinan Therapeutics Inc           | Cullinan Therapeutics, Inc.                   | CUSIP: 230031106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5343 | NS      | $55300.05     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytokinetics Inc                    | Cytokinetics, Inc.                            | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |      8546 | NS      | $543012.84    | 1.32%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytomx Therapeutics Inc             | CytomX Therapeutics, Inc.                     | CUSIP: 23284F105<br>LEI: 5493004VW2FW0QLL3345 | Long             | EC               | CORP              | US        |     23702 | NS      | $100970.52    | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Day One Biopharmaceuticals Inc.     | Day One Biopharmaceuticals, Inc.              | CUSIP: 23954D109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     13603 | NS      | $126779.96    | 0.31%             |  |  |  | No            |                  1 | On Loan: No      |
| Denali Therapeutics Inc             | Denali Therapeutics, Inc.                     | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |     16596 | NS      | $273999.96    | 0.67%             |  |  |  | No            |                  1 | On Loan: No      |
| Dianthus Therapeutics Inc           | Dianthus Therapeutics, Inc.                   | CUSIP: 252828108<br>LEI: 549300Z3N6ODPCOFC890 | Long             | EC               | CORP              | US        |      5014 | NS      | $206626.94    | 0.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Disc Medicine Inc                   | Disc Medicine, Inc.                           | CUSIP: 254604101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3127 | NS      | $248315.07    | 0.60%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                 | Eli Lilly & Company                           | CUSIP: N/A<br>LEI: N/A                        | Long             |  | CORP              | US        |      6633 | NS      | $4178.79      | 0.01%             |  |  |  | No            |                  3 | On Loan: No      |
| Dynavax Technologies Corp.          | Dynavax Technologies Corporation              | CUSIP: 268158201<br>LEI: 549300T5URIXWDILX594 | Long             | EC               | CORP              | US        |     15934 | NS      | $245064.92    | 0.60%             |  |  |  | No            |                  1 | On Loan: No      |
| Dyne Therapeutics Inc.              | Dyne Therapeutics, Inc.                       | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     20299 | NS      | $397048.44    | 0.96%             |  |  |  | No            |                  1 | On Loan: No      |
| Emergent Biosolutions Inc           | Emergent BioSolutions, Inc.                   | CUSIP: 29089Q105<br>LEI: 549300YW6TUOX8BE5103 | Long             | EC               | CORP              | US        |      7712 | NS      | $95320.32     | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Erasca Inc                          | Erasca, Inc.                                  | CUSIP: 29479A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     11351 | NS      | $42225.72     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Exact Sciences Corporation          | Exact Sciences Corporation                    | CUSIP: 30063P105<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |      4978 | NS      | $505565.68    | 1.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Exelixis, Inc.                      | Exelixis, Inc.                                | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |     12271 | NS      | $537837.93    | 1.31%             |  |  |  | No            |                  1 | On Loan: No      |
| 4D Molecular Therapeutics Inc       | 4D Molecular Therapeutics, Inc.               | CUSIP: 35104E100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7226 | NS      | $54195.00     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Geron Corp.                         | Geron Corporation                             | CUSIP: 374163103<br>LEI: 549300T282D7Z2YESL90 | Long             | EC               | CORP              | US        |     71204 | NS      | $93989.28     | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Gilead Sciences Inc.                | Gilead Sciences, Inc.                         | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |      4154 | NS      | $509861.96    | 1.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Gossamer Bio Inc                    | Gossamer Bio, Inc.                            | CUSIP: 38341P102<br>LEI: 549300ZOC0N2W6PSFR58 | Long             | EC               | CORP              | US        |     27100 | NS      | $84010.00     | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| GRAIL Inc                           | GRAIL, Inc.                                   | CUSIP: 384747101<br>LEI: 2549009XSNESW3VE8024 | Long             | EC               | CORP              | US        |      5309 | NS      | $454397.31    | 1.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Halozyme Therapeutics Inc           | Halozyme Therapeutics, Inc.                   | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |      8044 | NS      | $541361.20    | 1.31%             |  |  |  | No            |                  1 | On Loan: No      |
| IDEAYA Biosciences Inc.             | Ideaya Biosciences, Inc.                      | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |     10947 | NS      | $378437.79    | 0.92%             |  |  |  | No            |                  1 | On Loan: No      |
| Immuneering Corp.                   | Immuneering Corp.                             | CUSIP: 45254E107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     11327 | NS      | $74531.66     | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| ImmunityBio Inc                     | ImmunityBio, Inc.                             | CUSIP: 45256X103<br>LEI: 529900J9XLBR4HFL4B83 | Long             | EC               | CORP              | US        |     52616 | NS      | $104179.68    | 0.25%             |  |  |  | No            |                  1 | On Loan: —       |
| Immunome Inc                        | Immunome, Inc.                                | CUSIP: 45257U108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      9824 | NS      | $211019.52    | 0.51%             |  |  |  | No            |                  1 | On Loan: No      |
| Immunovant Inc                      | Immunovant, Inc.                              | CUSIP: 45258J102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     11466 | NS      | $291465.72    | 0.71%             |  |  |  | No            |                  1 | On Loan: No      |
| Incyte Corporation.                 | Incyte Corporation                            | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |      5295 | NS      | $522987.15    | 1.27%             |  |  |  | No            |                  1 | On Loan: No      |
| Inhibrx Biosciences  Inc.           | Inhibrx Biosciences, Inc.                     | CUSIP: 45720N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       744 | NS      | $58776.00     | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Insmed Inc                          | Insmed, Inc.                                  | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |      2655 | NS      | $462076.20    | 1.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Intellia Therapeutics Inc           | Intellia Therapeutics, Inc.                   | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |     18663 | NS      | $167780.37    | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Ionis Pharmaceuticals, Inc.         | Ionis Pharmaceuticals, Inc.                   | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |      6410 | NS      | $507095.10    | 1.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Iovance Biotherapeutics Inc         | Iovance Biotherapeutics, Inc.                 | CUSIP: 462260100<br>LEI: 2549002L8WT2ACU5Q878 | Long             | EC               | CORP              | US        |     61203 | NS      | $167084.19    | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Ironwood Pharmaceuticals, Inc.      | Ironwood Pharmaceuticals, Inc.                | CUSIP: 46333X108<br>LEI: 549300PC8MR6QHH6P296 | Long             | EC               | CORP              | US        |      5617 | NS      | $18929.29     | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Janux Therapeutics Inc              | Janux Therapeutics, Inc.                      | CUSIP: 47103J105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     15193 | NS      | $209663.40    | 0.51%             |  |  |  | No            |                  1 | On Loan: No      |
| KalVista Pharmaceuticals Inc.       | KalVista Pharmaceuticals, Inc.                | CUSIP: 483497103<br>LEI: 529900Q7IDA3WUGRZA51 | Long             | EC               | CORP              | US        |      5683 | NS      | $91780.45     | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Keros Therapeutics Inc.             | Keros Therapeutics, Inc.                      | CUSIP: 492327101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2623 | NS      | $53404.28     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Kodiak Sciences Inc                 | Kodiak Sciences, Inc.                         | CUSIP: 50015M109<br>LEI: 254900IXI5NI8C9OQE24 | Long             | EC               | CORP              | US        |      5156 | NS      | $144161.76    | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Krystal Biotech Inc                 | Krystal Biotech, Inc.                         | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |      2102 | NS      | $518227.08    | 1.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Kura Oncology Inc.                  | Kura Oncology, Inc.                           | CUSIP: 50127T109<br>LEI: 5493005QORQTZCZYOP39 | Long             | EC               | CORP              | US        |     16235 | NS      | $168681.65    | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Kymera Therapeutics Inc             | Kymera Therapeutics, Inc.                     | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5081 | NS      | $395352.61    | 0.96%             |  |  |  | No            |                  1 | On Loan: No      |
| Lexeo Therapeutics Inc              | Lexeo Therapeutics, Inc.                      | CUSIP: 52886X107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8850 | NS      | $87880.50     | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Madrigal Pharmaceuticals Inc        | Madrigal Pharmaceuticals, Inc.                | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |       912 | NS      | $531094.08    | 1.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Mannkind Corporation                | MannKind Corporation                          | CUSIP: 56400P706<br>LEI: 213800GFBCNY1ZFST722 | Long             | EC               | CORP              | US        |     39199 | NS      | $222258.33    | 0.54%             |  |  |  | No            |                  1 | On Loan: No      |
| MiMedx Group Inc.                   | MiMedx Group, Inc.                            | CUSIP: 602496101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6004 | NS      | $40647.08     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Mineralys Therapeutics Inc.         | Mineralys Therapeutics, Inc.                  | CUSIP: 603170101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     11082 | NS      | $402165.78    | 0.98%             |  |  |  | No            |                  1 | On Loan: No      |
| Mirum Pharmaceuticals Inc.          | Mirum Pharmaceuticals, Inc.                   | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |      6319 | NS      | $499137.81    | 1.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Moderna Inc                         | Moderna, Inc.                                 | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |     17356 | NS      | $511828.44    | 1.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Monte Rosa Therapeutics Inc         | Monte Rosa Therapeutics, Inc.                 | CUSIP: 61225M102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5843 | NS      | $91618.24     | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Myriad Genetics Inc.                | Myriad Genetics, Inc.                         | CUSIP: 62855J104<br>LEI: 52990044IHUOUMETT163 | Long             | EC               | CORP              | US        |     12928 | NS      | $79507.20     | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Natera Inc.                         | Natera, Inc.                                  | CUSIP: 632307104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2162 | NS      | $495292.58    | 1.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences Inc          | Neurocrine Biosciences, Inc.                  | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |      3238 | NS      | $459245.54    | 1.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Novavax Inc                         | Novavax, Inc.                                 | CUSIP: 670002401<br>LEI: 529900J4GJHPEPQ23205 | Long             | EC               | CORP              | US        |     28545 | NS      | $191822.40    | 0.47%             |  |  |  | No            |                  1 | On Loan: —       |
| Nuvalent Inc                        | Nuvalent, Inc.                                | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3980 | NS      | $400348.20    | 0.97%             |  |  |  | No            |                  1 | On Loan: No      |
| Nurix Therapeutics Inc.             | Nurix Therapeutics, Inc.                      | CUSIP: 67080M103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7842 | NS      | $148762.74    | 0.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Olema Pharmaceuticals Inc.          | Olema Pharmaceuticals, Inc.                   | CUSIP: 68062P106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3899 | NS      | $97475.00     | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| ORIC Pharmaceuticals Inc.           | ORIC Pharmaceuticals, Inc.                    | CUSIP: 68622P109<br>LEI: 54930033FJRNEYBW0L25 | Long             | EC               | CORP              | US        |     15350 | NS      | $125563.00    | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Oruka Therapeutics Inc              | Oruka Therapeutics, Inc.                      | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |      3334 | NS      | $101053.54    | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC Therapeutics, Inc.              | PTC Therapeutics, Inc.                        | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |      6801 | NS      | $516603.96    | 1.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Palvella Therapeutics Inc.          | Palvella Therapeutics, Inc.                   | CUSIP: 697947109<br>LEI: 254900AJDH8PAOOI5T33 | Long             | EC               | CORP              | US        |      1363 | NS      | $142665.21    | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Praxis Precision Medicines Inc      | Praxis Precision Medicines, Inc.              | CUSIP: 74006W207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1927 | NS      | $567963.98    | 1.38%             |  |  |  | No            |                  1 | On Loan: No      |
| Precigen Inc                        | Precigen, Inc.                                | CUSIP: 74017N105<br>LEI: 549300XCWNQU35K64G19 | Long             | EC               | CORP              | US        |     32419 | NS      | $135511.42    | 0.33%             |  |  |  | No            |                  1 | On Loan: No      |
| Prime Medicine Inc                  | Prime Medicine, Inc.                          | CUSIP: 74168J101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     16262 | NS      | $56429.14     | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Protagonist Therapeutics Inc        | Protagonist Therapeutics, Inc.                | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5515 | NS      | $481680.10    | 1.17%             |  |  |  | No            |                  1 | On Loan: No      |
| RAPT Therapeutics Inc.              | RAPT Therapeutics, Inc.                       | CUSIP: 75382E208<br>LEI: 549300MB473BIU78ES48 | Long             | EC               | CORP              | US        |      2858 | NS      | $96800.46     | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Recursion Pharmaceuticals Inc       | Recursion Pharmaceuticals, Inc.               | CUSIP: 75629V104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     83933 | NS      | $343285.97    | 0.83%             |  |  |  | No            |                  1 | On Loan: —       |
| Regeneron Pharmaceuticals, Inc.     | Regeneron Pharmaceuticals, Inc.               | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |       694 | NS      | $535677.78    | 1.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Regenxbio Inc.                      | REGENXBIO, Inc.                               | CUSIP: 75901B107<br>LEI: 549300EOES47LATSET33 | Long             | EC               | CORP              | US        |      5129 | NS      | $73857.60     | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Relay Therapeutics Inc              | Relay Therapeutics, Inc.                      | CUSIP: 75943R102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     16786 | NS      | $142009.56    | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Replimune Group Inc                 | Replimune Group, Inc.                         | CUSIP: 76029N106<br>LEI: 549300AY704NEIRC4K64 | Long             | EC               | CORP              | US        |     12208 | NS      | $118661.76    | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Revolution Medicines Inc            | Revolution Medicines, Inc.                    | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |      6471 | NS      | $515415.15    | 1.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Rezolute Inc                        | Rezolute, Inc.                                | CUSIP: 76200L309<br>LEI: 549300T05L48T72P2G08 | Long             | EC               | CORP              | US        |     12076 | NS      | $28499.36     | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Rhythm Pharmaceuticals Inc          | Rhythm Pharmaceuticals, Inc.                  | CUSIP: 76243J105<br>LEI: 529900JPNWXQ8DPLA551 | Long             | EC               | CORP              | US        |      4810 | NS      | $514862.40    | 1.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Rigel Pharmaceuticals Inc.          | Rigel Pharmaceuticals, Inc.                   | CUSIP: 766559702<br>LEI: 529900KPTNUS5J8K9K66 | Long             | EC               | CORP              | US        |      3734 | NS      | $159927.22    | 0.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Sana Biotechnology Inc              | Sana Biotechnology, Inc.                      | CUSIP: 799566104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     23752 | NS      | $96670.64     | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Sarepta Therapeutics Inc            | Sarepta Therapeutics, Inc.                    | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |     16916 | NS      | $364032.32    | 0.88%             |  |  |  | No            |                  1 | On Loan: No      |
| Savara Inc                          | Savara, Inc.                                  | CUSIP: 805111101<br>LEI: 5493002JO0WM3YMJXG33 | Long             | EC               | CORP              | US        |      7785 | NS      | $46943.55     | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Scholar Rock Holding Corp.          | Scholar Rock Holding Corporation              | CUSIP: 80706P103<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |     11187 | NS      | $492787.35    | 1.20%             |  |  |  | No            |                  1 | On Loan: No      |
| ARS Pharmaceuticals Inc             | ARS Pharmaceuticals, Inc.                     | CUSIP: 82835W108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     10012 | NS      | $116639.80    | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Sionna Therapeutics Inc.            | Sionna Therapeutics, Inc.                     | CUSIP: 829401108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2139 | NS      | $87998.46     | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Soleno Therapeutics Inc             | Soleno Therapeutics, Inc.                     | CUSIP: 834203309<br>LEI: 5493003LCY77N7FXK844 | Long             | EC               | CORP              | US        |      8282 | NS      | $383456.60    | 0.93%             |  |  |  | No            |                  1 | On Loan: No      |
| Stoke Therapeutics Inc              | Stoke Therapeutics, Inc.                      | CUSIP: 86150R107<br>LEI: 549300RD25SS2DIJHJ67 | Long             | EC               | CORP              | US        |      7814 | NS      | $248016.36    | 0.60%             |  |  |  | No            |                  1 | On Loan: No      |
| Summit Therapeutics Inc.            | Summit Therapeutics, Inc.                     | CUSIP: 86627T108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     24934 | NS      | $436095.66    | 1.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Syndax Pharmaceuticals Inc.         | Syndax Pharmaceuticals, Inc.                  | CUSIP: 87164F105<br>LEI: 529900OF94TRHKZVBS87 | Long             | EC               | CORP              | US        |     14030 | NS      | $294770.30    | 0.72%             |  |  |  | No            |                  1 | On Loan: No      |
| Tango Therapeutics Inc.             | Tango Therapeutics, Inc.                      | CUSIP: 87583X109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     19632 | NS      | $173939.52    | 0.42%             |  |  |  | No            |                  1 | On Loan: —       |
| Taysha Gene Therapies Inc.          | Taysha Gene Therapies, Inc.                   | CUSIP: 877619106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     29870 | NS      | $164285.00    | 0.40%             |  |  |  | No            |                  1 | On Loan: No      |
| TG Therapeutics Inc                 | TG Therapeutics, Inc.                         | CUSIP: 88322Q108<br>LEI: 529900X21UKABN9NJ529 | Long             | EC               | CORP              | US        |     16470 | NS      | $490970.70    | 1.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Travere Therapeutics Inc            | Travere Therapeutics, Inc.                    | CUSIP: 89422G107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     14659 | NS      | $560120.39    | 1.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Twist Bioscience Corporation        | Twist Bioscience Corporation                  | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |      9899 | NS      | $313996.28    | 0.76%             |  |  |  | No            |                  1 | On Loan: No      |
| Tyra Biosciences Inc                | Tyra Biosciences, Inc.                        | CUSIP: 90240B106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1339 | NS      | $35202.31     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Ultragenyx Pharmaceuticals Inc      | Ultragenyx Pharmaceutical, Inc.               | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |     13607 | NS      | $312961.00    | 0.76%             |  |  |  | No            |                  1 | On Loan: No      |
| United Therapeutics Corporation     | United Therapeutics Corporation               | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |      1039 | NS      | $506252.75    | 1.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Upstream Bio Inc                    | Upstream Bio, Inc.                            | CUSIP: 91678A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3351 | NS      | $90979.65     | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Vaxcyte Inc                         | Vaxcyte, Inc.                                 | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |     11589 | NS      | $534716.46    | 1.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Verastem Inc                        | Verastem, Inc.                                | CUSIP: 92337C203<br>LEI: 549300IY0EFBIU8NQC81 | Long             | EC               | CORP              | US        |     11205 | NS      | $86502.60     | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Veracyte Inc                        | Veracyte, Inc.                                | CUSIP: 92337F107<br>LEI: 529900ESWZRHXOW27Z37 | Long             | EC               | CORP              | US        |      7482 | NS      | $314992.20    | 0.76%             |  |  |  | No            |                  1 | On Loan: No      |
| Vera Therapeutics Inc.              | Vera Therapeutics, Inc.                       | CUSIP: 92337R101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7436 | NS      | $376559.04    | 0.91%             |  |  |  | No            |                  1 | On Loan: No      |
| Vericel Corporation                 | Vericel Corporation                           | CUSIP: 92346J108<br>LEI: 54930076YM3PLTDR4B91 | Long             | EC               | CORP              | US        |      6549 | NS      | $235829.49    | 0.57%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals Incorporated | Vertex Pharmaceuticals, Inc.                  | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |      1133 | NS      | $513656.88    | 1.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Viking Therapeutics Inc.            | Viking Therapeutics, Inc.                     | CUSIP: 92686J106<br>LEI: 529900IVC72YPFA25M37 | Long             | EC               | CORP              | US        |     13429 | NS      | $472432.22    | 1.15%             |  |  |  | No            |                  1 | On Loan: No      |
| VIR Biotechnology Inc               | Vir Biotechnology, Inc.                       | CUSIP: 92764N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     11589 | NS      | $69881.67     | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Viridian Therapeutics Inc           | Viridian Therapeutics, Inc.                   | CUSIP: 92790C104<br>LEI: 549300C775BNYF550E70 | Long             | EC               | CORP              | US        |      8642 | NS      | $268939.04    | 0.65%             |  |  |  | No            |                  1 | On Loan: No      |
| Xencor Inc                          | Xencor, Inc.                                  | CUSIP: 98401F105<br>LEI: 549300V5IF65437JKG30 | Long             | EC               | CORP              | US        |      8468 | NS      | $129645.08    | 0.31%             |  |  |  | No            |                  1 | On Loan: No      |
| AGPXX                               | Invesco Government & Agency Portfolio         | CUSIP: 825252885<br>LEI: N/A                  | Long             | STIV             | RF                | US        |   1308599 | NS      | $1308598.75   | 3.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Alkermes PLC                        | Alkermes plc                                  | CUSIP: G01767105<br>LEI: N/A                  | Long             | EC               | CORP              | IE        |     17610 | NS      | $492727.80    | 1.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Biohaven Ltd                        | Biohaven Ltd.                                 | CUSIP: G1110E107<br>LEI: N/A                  | Long             | EC               | CORP              | VG        |     18133 | NS      | $204721.57    | 0.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Prothena Corporation PLC            | Prothena Corp plc                             | CUSIP: G72800108<br>LEI: 5299009ZXQ8NIIJ8OL30 | Long             | EC               | CORP              | IE        |      7152 | NS      | $68301.60     | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Roivant Sciences Ltd                | Roivant Sciences Ltd.                         | CUSIP: G76279101<br>LEI: 549300DL466NY5J6U724 | Long             | EC               | CORP              | US        |     24901 | NS      | $540351.70    | 1.31%             |  |  |  | No            |                  1 | On Loan: No      |
| CRISPR Therapeutics AG              | CRISPR Therapeutics A.G.                      | CUSIP: H17182108<br>LEI: 506700O6IRRIQLT3W370 | Long             | EC               | CORP              | CH        |      8751 | NS      | $458902.44    | 1.11%             |  |  |  | No            |                  1 | On Loan: —       |
| N/A                                 | HSBC SECURITIES (USA), INC.  3.65 , 1/02/2025 | CUSIP: N/A<br>LEI: N/A                        | Long             | RA               | CORP              | US        |     52000 | PA      | $52000.00     | 0.13%             |  |  |  | No            |                  2 | On Loan: No      |
| Uniqure N.V.                        | uniQure N.V.                                  | CUSIP: N90064101<br>LEI: 724500RPCTZLFYJZ3S98 | Long             | EC               | CORP              | NL        |     14289 | NS      | $341935.77    | 0.83%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                 | NATWEST MARKETS PLC  3.72 , 1/02/2025         | CUSIP: N/A<br>LEI: N/A                        | Long             | RA               | CORP              | US        |     96000 | PA      | $96000.00     | 0.23%             |  |  |  | No            |                  2 | On Loan: No      |
| N/A                                 | ROYAL BANK OF CANADA  3.54 , 1/02/2025        | CUSIP: N/A<br>LEI: N/A                        | Long             | RA               | CORP              | US        |     52000 | PA      | $52000.00     | 0.13%             |  |  |  | No            |                  2 | On Loan: No      |
| N/A                                 | SOCIETE' GENERALE  3.66 , 1/02/2025           | CUSIP: N/A<br>LEI: N/A                        | Long             | RA               | CORP              | US        |    122000 | PA      | $122000.00    | 0.30%             |  |  |  | No            |                  2 | On Loan: No      |
| N/A                                 | UMB FINANCIAL CORP.  3.49 , 1/02/2025         | CUSIP: N/A<br>LEI: N/A                        | Long             | RA               | CORP              | US        |     49000 | PA      | $49000.00     | 0.12%             |  |  |  | No            |                  2 | On Loan: No      |

### Signature

**Date Signed:** 2025-12-31

**Name of Applicant:** ProFund VP Biotechnology

**Signature:** Rebecca Colvin

**Name of Signer:** Rebecca Colvin

**Title:** Treasurer and Principal Financial Officer