# EDGAR Filing Document

**Accession Number:** 0001802630
**File Stem:** 0001802630-23-000003
**Filing Date:** 2023-2
**Character Count:** 10844
**Document Hash:** d4a11f6a55d00c852c33cb0564155ab3
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001802630-23-000003.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001802630-23-000003

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**EFFECTIVENESS DATE**: 20230214

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Soleus Capital Management, L.P.
- **CENTRAL INDEX KEY:** 0001802630
- **IRS NUMBER:** 384052641
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-20043
- **FILM NUMBER:** 23627824

**BUSINESS ADDRESS:**
- **STREET 1:** 104 FIELD POINT ROAD
- **STREET 2:** FLOOR 2
- **CITY:** GREENWICH
- **STATE:** CT
- **ZIP:** 06830
- **BUSINESS PHONE:** 203-542-5527

**MAIL ADDRESS:**
- **STREET 1:** 104 FIELD POINT ROAD
- **STREET 2:** FLOOR 2
- **CITY:** GREENWICH
- **STATE:** CT
- **ZIP:** 06830

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2022

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** Soleus Capital Management L.P.<br>**Address:** 104 FIELD POINT ROAD<br>FLOOR 2<br>GREENWICH, CT 06830

**Form 13F File Number:** 028-20043

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Steven J. Musumeci<br>**Title:** Chief Operating Officer Soleus Capital Management L.P.<br>**Phone:** (475) 208-3111

**Signature, Place, and Date of Signing:**

/s/ Steven J. Musumeci  Greenwich, CT  02-14-2023<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 72

**Form 13F Information Table Value Total:** $697057805

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| 10X GENOMICS INC | CL A COM | 88025U109 |  | 2550800 | 70000 | SH |  | SOLE |  | 70000 | 0 | 0 |
| 4D MOLECULAR THERAPEUTICS IN | COM | 35104E100 |  | 5656887 | 254700 | SH |  | SOLE |  | 254700 | 0 | 0 |
| 89BIO INC | COM | 282559103 |  | 4824670 | 379000 | SH |  | SOLE |  | 379000 | 0 | 0 |
| AEROVATE THERAPEUTICS INC | COM | 008064107 |  | 6361587 | 217119 | SH |  | SOLE |  | 217119 | 0 | 0 |
| AMYLYX PHARMACEUTICALS INC | COM | 03237H101 |  | 1871000 | 50636 | SH |  | SOLE |  | 50636 | 0 | 0 |
| ANAPTYSBIO INC | COM | 032724106 |  | 456390 | 14727 | SH |  | SOLE |  | 14727 | 0 | 0 |
| ARCELLX INC | COMMON STOCK | 03940C100 |  | 34153808 | 1102447 | SH |  | SOLE |  | 1102447 | 0 | 0 |
| AVIDITY BIOSCIENCES INC | COM | 05370A108 |  | 6878900 | 310000 | SH |  | SOLE |  | 310000 | 0 | 0 |
| AXOGEN INC | COM | 05463X106 |  | 7544860 | 755998 | SH |  | SOLE |  | 755998 | 0 | 0 |
| AXSOME THERAPEUTICS INC | COM | 05464T104 |  | 3856500 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| BERKELEY LTS INC | COM | 084310101 |  | 3564400 | 1330000 | SH |  | SOLE |  | 1330000 | 0 | 0 |
| BICYCLE THERAPEUTICS PLC | SPONSORED ADS | 088786108 |  | 7648640 | 258400 | SH |  | SOLE |  | 258400 | 0 | 0 |
| BIOATLA INC | COM | 09077B104 |  | 34818275 | 4220397 | SH |  | SOLE |  | 4220397 | 0 | 0 |
| C4 THERAPEUTICS INC | COM STK | 12529R107 |  | 14400974 | 2440843 | SH |  | SOLE |  | 2440843 | 0 | 0 |
| CELCUITY INC | COM | 15102K100 |  | 16955294 | 1210228 | SH |  | SOLE |  | 1210228 | 0 | 0 |
| CHARLES RIV LABS INTL INC | COM | 159864107 |  | 22193115 | 101850 | SH |  | SOLE |  | 101850 | 0 | 0 |
| CHINOOK THERAPEUTICS INC | COM | 16961L106 |  | 2043600 | 78000 | SH |  | SOLE |  | 78000 | 0 | 0 |
| CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 |  | 894300 | 22000 | SH |  | SOLE |  | 22000 | 0 | 0 |
| CUTERA INC | COM | 232109108 |  | 884400 | 20000 | SH |  | SOLE |  | 20000 | 0 | 0 |
| CVRX INC | COM | 126638105 |  | 18618644 | 1014640 | SH |  | SOLE |  | 1014640 | 0 | 0 |
| CVS HEALTH CORP | COM | 126650100 |  | 8830125 | 94754 | SH |  | SOLE |  | 94754 | 0 | 0 |
| DEXCOM INC | COM | 252131107 |  | 4529600 | 40000 | SH |  | SOLE |  | 40000 | 0 | 0 |
| DICE THERAPEUTICS INC | COM | 23345J104 |  | 5411546 | 173447 | SH |  | SOLE |  | 173447 | 0 | 0 |
| EDAP TMS S A | SPONSORED ADR | 268311107 |  | 54733024 | 5134430 | SH |  | SOLE |  | 5134430 | 0 | 0 |
| ENANTA PHARMACEUTICALS INC | COM | 29251M106 |  | 6411107 | 137814 | SH |  | SOLE |  | 137814 | 0 | 0 |
| ENOVIS CORPORATION | COM | 194014502 |  | 5084400 | 95000 | SH |  | SOLE |  | 95000 | 0 | 0 |
| ESSA PHARMA INC | COM NEW | 29668H708 |  | 9750868 | 3869392 | SH |  | SOLE |  | 3869392 | 0 | 0 |
| ESTABLISHMENT LABS HLDGS INC | COM | G31249108 |  | 2620748 | 39920 | SH |  | SOLE |  | 39920 | 0 | 0 |
| EXACT SCIENCES CORP | COM | 30063P105 |  | 14224223 | 287300 | SH |  | SOLE |  | 287300 | 0 | 0 |
| FIBROGEN INC | COM | 31572Q808 |  | 1817677 | 113463 | SH |  | SOLE |  | 113463 | 0 | 0 |
| HCA HEALTHCARE INC | COM | 40412C101 |  | 8290618 | 34550 | SH |  | SOLE |  | 34550 | 0 | 0 |
| HUMANA INC | COM | 444859102 |  | 13701083 | 26750 | SH |  | SOLE |  | 26750 | 0 | 0 |
| ILLUMINA INC | COM | 452327109 |  | 4905776 | 24262 | SH |  | SOLE |  | 24262 | 0 | 0 |
| IMAGO BIOSCIENCES INC | COM | 45250K107 |  | 4134250 | 115000 | SH |  | SOLE |  | 115000 | 0 | 0 |
| INARI MED INC | COM | 45332Y109 |  | 14272398 | 224550 | SH |  | SOLE |  | 224550 | 0 | 0 |
| INHIBRX INC | COM | 45720L107 |  | 11785361 | 478302 | SH |  | SOLE |  | 478302 | 0 | 0 |
| INSPIRE MED SYS INC | COM | 457730109 |  | 11636856 | 46200 | SH |  | SOLE |  | 46200 | 0 | 0 |
| INTUITIVE SURGICAL INC | COM NEW | 46120E602 |  | 2547360 | 9600 | SH |  | SOLE |  | 9600 | 0 | 0 |
| IRADIMED CORP | COM | 46266A109 |  | 21076163 | 745004 | SH |  | SOLE |  | 745004 | 0 | 0 |
| IVERIC BIO INC | COM | 46583P102 |  | 45276326 | 2114728 | SH |  | SOLE |  | 2114728 | 0 | 0 |
| KEROS THERAPEUTICS INC | COM | 492327101 |  | 11194230 | 233116 | SH |  | SOLE |  | 233116 | 0 | 0 |
| KRYSTAL BIOTECH INC | COM | 501147102 |  | 14910551 | 188217 | SH |  | SOLE |  | 188217 | 0 | 0 |
| LILLY ELI  CO | COM | 532457108 |  | 14304344 | 39100 | SH |  | SOLE |  | 39100 | 0 | 0 |
| LYRA THERAPEUTICS INC | COM | 55234L105 |  | 1860189 | 592417 | SH |  | SOLE |  | 592417 | 0 | 0 |
| NEOGEN CORP | COM | 640491106 |  | 2185505 | 143500 | SH |  | SOLE |  | 143500 | 0 | 0 |
| NEUROPACE INC | COM | 641288105 |  | 3529814 | 2369003 | SH |  | SOLE |  | 2369003 | 0 | 0 |
| ORGANOGENESIS HLDGS INC | COM | 68621F102 |  | 19806639 | 7363063 | SH |  | SOLE |  | 7363063 | 0 | 0 |
| ORTHOFIX MED INC | COM | 68752M108 |  | 6062509 | 295300 | SH |  | SOLE |  | 295300 | 0 | 0 |
| ORTHOPEDIATRICS CORP | COM | 68752L100 |  | 296823 | 7471 | SH |  | SOLE |  | 7471 | 0 | 0 |
| PARDES BIOSCIENCES INC | COM | 69945Q105 |  | 2112500 | 1250000 | SH |  | SOLE |  | 1250000 | 0 | 0 |
| PENUMBRA INC | COM | 70975L107 |  | 2068878 | 9300 | SH |  | SOLE |  | 9300 | 0 | 0 |
| PEPGEN INC | COM | 713317105 |  | 133700 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| PHARVARIS N V | COM | N69605108 |  | 3487500 | 310000 | SH |  | SOLE |  | 310000 | 0 | 0 |
| PIERIS PHARMACEUTICALS INC | COM | 720795103 |  | 1040000 | 1000000 | SH |  | SOLE |  | 1000000 | 0 | 0 |
| PROMETHEUS BIOSCIENCES INC | COM | 74349U108 |  | 3421000 | 31100 | SH |  | SOLE |  | 31100 | 0 | 0 |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 |  | 2574760 | 236000 | SH |  | SOLE |  | 236000 | 0 | 0 |
| PULMONX CORP | COM | 745848101 |  | 598530 | 71000 | SH |  | SOLE |  | 71000 | 0 | 0 |
| STAAR SURGICAL CO | COM PAR $0.01 | 852312305 |  | 5349108 | 110200 | SH |  | SOLE |  | 110200 | 0 | 0 |
| SURMODICS INC | COM | 868873100 |  | 26453611 | 775311 | SH |  | SOLE |  | 775311 | 0 | 0 |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 |  | 5599000 | 220000 | SH |  | SOLE |  | 220000 | 0 | 0 |
| TANDEM DIABETES CARE INC | COM NEW | 875372203 |  | 14046875 | 312500 | SH |  | SOLE |  | 312500 | 0 | 0 |
| TG THERAPEUTICS INC | COM | 88322Q108 |  | 2815540 | 238000 | SH |  | SOLE |  | 238000 | 0 | 0 |
| THE BEAUTY HEALTH COMPANY | COM CL A | 88331L108 |  | 12524949 | 1376368 | SH |  | SOLE |  | 1376368 | 0 | 0 |
| THERATECHNOLOGIES INC | COM | 88338H100 |  | 7767876 | 8799125 | SH |  | SOLE |  | 8799125 | 0 | 0 |
| TRANSMEDICS GROUP INC | COM | 89377M109 |  | 2684820 | 43500 | SH |  | SOLE |  | 43500 | 0 | 0 |
| UNITED THERAPEUTICS CORP DEL | COM | 91307C102 |  | 35670048 | 128268 | SH |  | SOLE |  | 128268 | 0 | 0 |
| VAXCYTE INC | COM | 92243G108 |  | 18602203 | 387950 | SH |  | SOLE |  | 387950 | 0 | 0 |
| VENTYX BIOSCIENCES INC | COM | 92332V107 |  | 2262510 | 69000 | SH |  | SOLE |  | 69000 | 0 | 0 |
| VERICEL CORP | COM | 92346J108 |  | 23942981 | 908997 | SH |  | SOLE |  | 908997 | 0 | 0 |
| XENON PHARMACEUTICALS INC | COM | 98420N105 |  | 1498340 | 38000 | SH |  | SOLE |  | 38000 | 0 | 0 |
| XILIO THERAPEUTICS INC | COM | 98422T100 |  | 610471 | 226941 | SH |  | SOLE |  | 226941 | 0 | 0 |
| Y-MABS THERAPEUTICS INC | COM | 984241109 |  | 425448 | 87182 | SH |  | SOLE |  | 87182 | 0 | 0 |

---