# EDGAR Filing Document

**Accession Number:** 0001833214
**File Stem:** 0000000000-25-009986
**Filing Date:** 2025-9
**Character Count:** 3947
**Document Hash:** f062224cb0e58088091d6151489d280b
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000000000-25-009986.hdr.sgml**: 20260625

**ACCESSION NUMBER**: 0000000000-25-009986

**CONFORMED SUBMISSION TYPE**: UPLOAD

**PUBLIC DOCUMENT COUNT**: 2

**FILED AS OF DATE**: 20250915

**FILED FOR**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** SAB Biotherapeutics, Inc.
- **CENTRAL INDEX KEY:** 0001833214
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 853899721
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** UPLOAD
- **SEC FILE NUMBER:** 333-289992

**BUSINESS ADDRESS:**
- **STREET 1:** 777 W 41ST ST
- **STREET 2:** SUITE 401
- **CITY:** MIAMI BEACH
- **STATE:** FL
- **ZIP:** 33140
- **BUSINESS PHONE:** 305-845-2813

**MAIL ADDRESS:**
- **STREET 1:** 777 W 41ST ST
- **STREET 2:** SUITE 401
- **CITY:** MIAMI BEACH
- **STATE:** FL
- **ZIP:** 33140

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Big Cypress Acquisition Corp.
- **DATE OF NAME CHANGE:** 20201120
**PUBLIC REFERENCE ACCESSION NUMBER**: 0001833214-25-000011

## Text-Extract

```

                                                             September 15, 2025

Samuel Reich
Chief Executive Officer
SAB Biotherapeutics, Inc.
777 W 41st St.
Suite 401
Miami Beach, FL 33140

       Re: SAB Biotherapeutics, Inc.
           Registration Statement on Form S-3
           Filed September 2, 2025
           File No. 333-289992
Dear Samuel Reich:

       We have conducted a limited review of your registration statement and
have the
following comment.

        Please respond to this letter by amending your registration statement
and providing
the requested information. If you do not believe our comment applies to your
facts and
circumstances or do not believe an amendment is appropriate, please tell us why
in your
response.

       After reviewing any amendment to your registration statement and the
information
you provide in response to this letter, we may have additional comments.

Registration Statement on Form S-3
Prospectus Summary
July 2025 Private Placement, page 2

1.     Please revise your disclosure in this section to clarify that the
conversion price for the
       Series B Preferred Stock is a component in the formula that will be used
to calculate
       the number of common shares issuable upon conversion of the Series B
Preferred
       Stock and that it is not consideration to be paid by preferred
stockholders for such
       conversion. In addition, disclose the formula, as described in Sections
6(b) and 6(c) of
       the Certificate of Designation of Preferences, Rights and Limitations of
Series B
       Convertible Preferred Stock, and briefly describe the adjustments that
may impact
       the formula (e.g., the adjustments described in Section 7 of the
Certificate of
 September 15, 2025
Page 2

       Designations). Please clarify, if true, that each share of Series B
Preferred Stock will
       initially be convertible into 100 shares of Common Stock.
        We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence
of action by the staff.

       Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration
statement.

       Please contact Jessica Dickerson at 202-551-8013 or Alan Campbell at
202-551-4224
with any questions.

                                                             Sincerely,

                                                             Division of
Corporation Finance
                                                             Office of Life
Sciences
cc:   Ilan Katz, Esq.

```

### Attached PDF Documents

**Attachment 1:** `filename1`

_No text found in this document._