# EDGAR Filing Document

**Accession Number:** 0001771821
**File Stem:** 0001104659-23-017651
**Filing Date:** 2023-2
**Character Count:** 25376
**Document Hash:** 641ce453da318ed75bf2f91b1414054e
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-23-017651.hdr.sgml**: 20230209

**ACCESSION NUMBER**: 0001104659-23-017651

**CONFORMED SUBMISSION TYPE**: SC 13G/A

**PUBLIC DOCUMENT COUNT**: 2

**FILED AS OF DATE**: 20230209

**DATE AS OF CHANGE**: 20230209

**GROUP MEMBERS**: INSPIRATIONAL VISIONS B.V.

**GROUP MEMBERS**: PATRICK JOHAN HENDRIK KROL

**GROUP MEMBERS**: PRIVIUM FUND MANAGEMENT B.V.

**GROUP MEMBERS**: STICHTING AESCAP GENETICS

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** ProQR Therapeutics N.V.
- **CENTRAL INDEX KEY:** 0001612940
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 000000000
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G/A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-88671
- **FILM NUMBER:** 23607138

**BUSINESS ADDRESS:**
- **STREET 1:** ZERNIKEDREEF 9
- **CITY:** LEIDEN
- **STATE:** P7
- **ZIP:** 2333 CK
- **BUSINESS PHONE:** 31 88 166 7000

**MAIL ADDRESS:**
- **STREET 1:** ZERNIKEDREEF 9
- **CITY:** LEIDEN
- **STATE:** P7
- **ZIP:** 2333 CK

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ProQR Therapeutics B.V.
- **DATE OF NAME CHANGE:** 20140708
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Stichting Aescap Life Sciences
- **CENTRAL INDEX KEY:** 0001771821
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** P7
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G/A

**BUSINESS ADDRESS:**
- **STREET 1:** GUSTAV MAHLERPLEIN 3
- **CITY:** AMSTERDAM
- **STATE:** P7
- **ZIP:** 1082 MS
- **BUSINESS PHONE:** 31 20 462 6644

**MAIL ADDRESS:**
- **STREET 1:** GUSTAV MAHLERPLEIN 3
- **CITY:** AMSTERDAM
- **STATE:** P7
- **ZIP:** 1082 MS

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Stichting Aescap 2.0
- **DATE OF NAME CHANGE:** 20190326

---

| |
|:---|
| **UNITED STATES** |
| **SECURITIES AND EXCHANGE COMMISSION** |
| **Washington, D.C. 20549** |

---

**SCHEDULE 13G**

**Under the Securities Exchange Act of 19341<br> (Amendment No. 4)\***

**ProQR Therapeutics N.V.**

(Name of Issuer)

**Ordinary Shares, nominal value €0.04 per share**

(Title of Class of Securities)

**N71542109**

(CUSIP Number)

**December 31, 2022**

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

◻ Rule 13d-1(b) <br> ⌧ Rule 13d-1(c) <br> ◻ Rule 13d-1(d)

\*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

CUSIP No. N71542109

---

| | | |
|:---|:---|:---|
| 1 | Name of Reporting Persons<br> Stichting Aescap Life Sciences | Name of Reporting Persons<br> Stichting Aescap Life Sciences |
| 2 | Check the Appropriate Box if a Member of a Group | Check the Appropriate Box if a Member of a Group |
|  | (a) | ◻ |
|  | (b) | ◻ |
| 3 | SEC Use Only | SEC Use Only |
| 4 | Citizenship or Place of Organization <br> The Netherlands | Citizenship or Place of Organization <br> The Netherlands |

---

---

| | | |
|:---|:---|:---|
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 5 | Sole Voting Power <br> 4,765,659 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 6 | Shared Voting Power <br> 0 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 7 | Sole Dispositive Power <br> 4,765,659 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 8 | Shared Dispositive Power <br> 0 |

---

---

| | |
|:---|:---|
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 4,765,659 |
| 10 | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ |
| 11 | Percent of Class Represented by Amount in Row (9)<br> 6.7% |
| 12 | Type of Reporting Person (See Instructions)<br> FI |

---

(1) Based upon 71,433,806 ordinary shares outstanding as of September 30, 2022, as disclosed in the Issuer's Report of Foreign Private Issuer on Form 6-K filed on November 9, 2022.

---

| | | |
|:---|:---|:---|
| 1 | Name of Reporting Persons<br> Privium Fund Management B.V. | Name of Reporting Persons<br> Privium Fund Management B.V. |
| 2 | Check the Appropriate Box if a Member of a Group | Check the Appropriate Box if a Member of a Group |
|  | (a) | ◻ |
|  | (b) | ◻ |
| 3 | SEC Use Only | SEC Use Only |
| 4 | Citizenship or Place of Organization <br> The Netherlands | Citizenship or Place of Organization <br> The Netherlands |

---

---

| | | |
|:---|:---|:---|
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 5 | Sole Voting Power <br> 4,765,659 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 6 | Shared Voting Power <br> 0 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 7 | Sole Dispositive Power <br> 5,344,446 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 8 | Shared Dispositive Power <br> 0 |

---

---

| | |
|:---|:---|
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 5,344,446 |
| 10 | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ |
| 11 | Percent of Class Represented by Amount in Row (9)<br> 7.5% |
| 12 | Type of Reporting Person (See Instructions)<br> FI |

---

(1) Based upon 71,433,806 ordinary shares outstanding as of September 30, 2022, as disclosed in the Issuer's Report of Foreign Private Issuer on Form 6-K filed on November 9, 2022

CUSIP No. N71542109

---

| | | |
|:---|:---|:---|
| 1 | Name of Reporting Persons<br> Stichting Aescap Genetics | Name of Reporting Persons<br> Stichting Aescap Genetics |
| 2 | Check the Appropriate Box if a Member of a Group | Check the Appropriate Box if a Member of a Group |
|  | (a) | ◻ |
|  | (b) | ◻ |
| 3 | SEC Use Only | SEC Use Only |
| 4 | Citizenship or Place of Organization <br> The Netherlands | Citizenship or Place of Organization <br> The Netherlands |

---

---

| | | |
|:---|:---|:---|
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 5 | Sole Voting Power <br> 578,787 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 6 | Shared Voting Power <br> 0 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 7 | Sole Dispositive Power <br> 578,787 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 8 | Shared Dispositive Power <br> 0 |

---

---

| | |
|:---|:---|
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 578,787 |
| 10 | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ |
| 11 | Percent of Class Represented by Amount in Row (9)<br> 0.8% |
| 12 | Type of Reporting Person (See Instructions)<br> FI |

---

(1) Based upon 71,433,806 ordinary shares outstanding as of September 30, 2022, as disclosed in the Issuer's Report of Foreign Private Issuer on Form 6-K filed on November 9, 2022.

CUSIP No. N71542109

---

| | | |
|:---|:---|:---|
| 1 | Name of Reporting Persons<br> Inspirational Visions BV | Name of Reporting Persons<br> Inspirational Visions BV |
| 2 | Check the Appropriate Box if a Member of a Group | Check the Appropriate Box if a Member of a Group |
|  | (a) | ◻ |
|  | (b) | ◻ |
| 3 | SEC Use Only | SEC Use Only |
| 4 | Citizenship or Place of Organization <br> The Netherlands | Citizenship or Place of Organization <br> The Netherlands |

---

---

| | | |
|:---|:---|:---|
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 5 | Sole Voting Power <br> 35,411 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 6 | Shared Voting Power <br> 0 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 7 | Sole Dispositive Power <br> 35,411 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 8 | Shared Dispositive Power <br> 0 |

---

---

| | |
|:---|:---|
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 35,411 |
| 10 | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ |
| 11 | Percent of Class Represented by Amount in Row (9)<br> 0.1% |
| 12 | Type of Reporting Person (See Instructions)<br> FI |

---

(1) Based upon 71,433,806 ordinary shares outstanding as of September 30, 2022, as disclosed in the Issuer's Report of Foreign Private Issuer on Form 6-K filed on November 9, 2022

---

| | | |
|:---|:---|:---|
| 1 | Name of Reporting Persons<br> Patrick Johan Hendrik Krol | Name of Reporting Persons<br> Patrick Johan Hendrik Krol |
| 2 | Check the Appropriate Box if a Member of a Group | Check the Appropriate Box if a Member of a Group |
|  | (a) | ◻ |
|  | (b) | ◻ |
| 3 | SEC Use Only | SEC Use Only |
| 4 | Citizenship or Place of Organization <br> The Netherlands | Citizenship or Place of Organization <br> The Netherlands |

---

---

| | | |
|:---|:---|:---|
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 5 | Sole Voting Power <br> 5,406,159 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 6 | Shared Voting Power <br> 0 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 7 | Sole Dispositive Power <br> 5,406,159 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 8 | Shared Dispositive Power <br> 0 |

---

---

| | |
|:---|:---|
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 5,406,159 |
| 10 | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ |
| 11 | Percent of Class Represented by Amount in Row (9)<br> 7.6% |
| 12 | Type of Reporting Person (See Instructions)<br> IN |

---

(1) Based upon 71,433,806 ordinary shares outstanding as of September 30, 2022, as disclosed in the Issuer's Report of Foreign Private Issuer on Form 6-K filed on November 9, 2022.

---

| | | |
|:---|:---|:---|
| **Item 1.** | (a). | Name of Issuer<br> ProQR Therapeutics N.V. (the "Issuer") |
|  | (b). | Address of Issuer's Principal Executive Offices:<br> Zernikedreef 9, 2333 CK Leiden, The Netherlands |
| **Item 2(a).** | **Item 2(a).** | Name of Person Filing |
| **Item 2(b).** | **Item 2(b).** | Address of Principal Business Office |
| **Item 2(c).** | **Item 2(c).** | Citizenship<br> (i) Stichting Aescap Life Sciences ("Aescap Life Sciences")<br> Gustav Mahlerplein 3<br> 1082 MS Amsterdam<br> The Netherlands<br> Citizenship: The Netherlands<br>(ii) Privium Fund Management B.V. ("Privium"), as the fund manager of Aescap Life Sciences<br> Gustav Mahlerplein 3<br> 1082 MS Amsterdam<br> The Netherlands<br> Citizenship: The Netherlands<br>(iii) Stichting Aescap Genetics ("Aescap Genetics")<br> Gustav Mahlerplein 3<br> 1082 MS Amsterdam<br> The Netherlands<br> Citizenship: The Netherlands<br>(iv) Inspirational Visions BV ("Inspirational Visions")<br> A.J. Ernststraat 595-C<br> 1082 LN Amsterdam<br> The Netherlands<br> Citizenship: The Netherlands<br>(v) Patrick Johan Hendrik Krol ("Krol"), the portfolio manager for Privium and Aescap Genetics and the managing director of Inspirational Visions<br> Gustav Mahlerplein 3<br> 1082 MS Amsterdam<br> The Netherlands<br> Citizenship: The Netherlands<br>The foregoing persons are hereinafter sometimes collectively referred to as the "Reporting Persons." |
| **Item 2(d).** | **Item 2(d).** | Title of Class of Securities:<br> Ordinary Shares, nominal value €0.04 per share (the "Shares") |
| **Item 2(e).** | **Item 2(e).** | CUSIP Number:<br> N71542109 |

---

---

| | |
|:---|:---|
| **Item 3.** | **If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b) or (c), check whether the person filing is a:** |
|  | This Item 3 is not applicable. |
| **Item 4.** | **Ownership.** |
| (a) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Amount beneficially owned:<br>As its Fund Manager, the Shares held by Aescap Life Sciences may be deemed to be beneficially owned by Privium. In addition, as its Fund Manager, the Shares held by Aescap Genetics may be deemed to be beneficially owned by Privium. As the portfolio manager of Privium, Krol may be deemed to beneficially own the Shares held by Aescap Life Sciences. In addition, as the managing director of Inspirational Visions, Krol may be deemed to beneficially own the Shares held by Inspirational Visions.<br>As of the date of this report, Aescap Life Sciences directly held 4,765,659 Shares. As of the date of this report, Aescap Genetics directly held 578,787 Shares. As of the date of this report, Inspirational Visions directly held 35,411 Shares. As of the date of this report, Krol directly held 26,302 Shares. |
| (b) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Percent of class:<br>Aescap Life Sciences may be deemed the beneficial owner of approximately 6.7% of the Shares outstanding.<br>Privium may be deemed the beneficial owner of approximately 7.5% of the Shares outstanding.<br>Aescap Genetics may be deemed the beneficial owner of approximately 0.8% of the Shares outstanding.<br>Inspirational Visions may be deemed the beneficial owner of approximately 0.1% of the Shares outstanding.<br>Krol may be deemed the beneficial owner of approximately 7.6% of the Shares outstanding. |
| (c) | Number of shares as to which the Reporting person has: |
|  | <u>Aescap Life Sciences:</u> |
| (i) | Sole power to vote or to direct the vote:<br> 4,765,659 |
| (ii) | Shared power to vote or to direct the vote:<br> 0 |
| (iii) | Sole power to dispose or to direct the disposition of:<br> 4,765,659 |
| (iv) | Shared power to dispose or to direct the disposition of:<br> 0 |
|  | <u>Privium:</u> |
| (i) | Sole power to vote or to direct the vote:<br> 5,344,446 |
| (ii) | Shared power to vote or to direct the vote:<br> 0 |
| (iii) | Sole power to dispose or to direct the disposition of:<br> 5,344,446 |
| (iv) | Shared power to dispose or to direct the disposition of:<br> 0 |

---

---

| | |
|:---|:---|
| <u>Aescap Genetics:</u> | <u>Aescap Genetics:</u> |
| (i) | Sole power to vote or to direct the vote:<br> 578,787 |
| (ii) | Shared power to vote or to direct the vote:<br> 0 |
| (iii) | Sole power to dispose or to direct the disposition of:<br> 578,787 |
| (iv) | Shared power to dispose or to direct the disposition of:<br> 0 |
| <u>Inspirational Visions:</u> | <u>Inspirational Visions:</u> |
| (i) | Sole power to vote or to direct the vote:<br> 35,411 |
| (ii) | Shared power to vote or to direct the vote:<br> 0 |
| (iii) | Sole power to dispose or to direct the disposition of:<br> 35,411 |
| (iv) | Shared power to dispose or to direct the disposition of:<br> 0 |
| <u>Krol:</u> | <u>Krol:</u> |
| (i) | Sole power to vote or to direct the vote:<br> 5,406,159 |
| (ii) | Shared power to vote or to direct the vote:<br> 0 |
| (iii) | Sole power to dispose or to direct the disposition of:<br> 5,406,159 |
| (iv) | Shared power to dispose or to direct the disposition of:<br> 0 |

---

---

| | |
|:---|:---|
| **Item 5.** | **Ownership of Five Percent or Less of a Class** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following: | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following: |
| **Item 6.** | **Ownership of More than Five Percent on Behalf of Another Person.** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Item 6 is not applicable. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Item 6 is not applicable. |
| **Item 7.** | **Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company.** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Item 7 is not applicable. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Item 7 is not applicable. |
| **Item 8.** | **Identification and Classification of Members of the Group.** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Item 8 is not applicable. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Item 8 is not applicable. |
| **Item 9.** | **Notice of Dissolution of Group.** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Item 9 is not applicable. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;This Item 9 is not applicable. |

---

---

| | |
|:---|:---|
| **Item 10.** | **Certification.** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Each of the Reporting Persons hereby makes the following certification:<br>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the Issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Each of the Reporting Persons hereby makes the following certification:<br>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the Issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. |

---

**SIGNATURE**

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

---

| | |
|:---|:---|
| **STICHTING AESCAP LIFE SCIENCES** | **STICHTING AESCAP LIFE SCIENCES** |
| **BY: PRIVIUM FUND MANAGEMENT B.V., ITS FUND MANAGER** | **BY: PRIVIUM FUND MANAGEMENT B.V., ITS FUND MANAGER** |
| By: | /s/ Patrick Johan Hendrik Krol |
| Name: | P.J.H. Krol |
| Title: | Portfolio Manager |
| **STICHTING AESCAP GENETICS** | **STICHTING AESCAP GENETICS** |
| **BY: PRIVIUM FUND MANAGEMENT B.V., ITS FUND MANAGER** | **BY: PRIVIUM FUND MANAGEMENT B.V., ITS FUND MANAGER** |
| By: | /s/ Patrick Johan Hendrik Krol |
| Name: | P.J.H. Krol |
| Title: | Portfolio Manager |
| **PRIVIUM FUND MANAGEMENT B.V.** | **PRIVIUM FUND MANAGEMENT B.V.** |
| By: | /s/ Patrick Johan Hendrik Krol |
| Name: | P.J.H. Krol |
| Title: | Portfolio Manager |
| **INSPIRATIONAL VISIONS B.V.** | **INSPIRATIONAL VISIONS B.V.** |
| By: | /s/ Patrick Johan Hendrik Krol |
| Name: | P.J.H. Krol |
| Title: | Managing Director |
| **PATRICK JOHAN HENDRIK KROL** | **PATRICK JOHAN HENDRIK KROL** |
|  | /s/ Patrick Johan Hendrik Krol |
| Dated: February 9, 2023 | Dated: February 9, 2023 |

---

## Exhibit 99.1

**Exhibit 99.1**

**Joint Filing Agreement**

The undersigned acknowledge and agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on Schedule 13G shall be filed on behalf of each of the undersigned without the necessity of filing additional joint filing statements. The undersigned acknowledge that each shall be responsible for the timely filing of such amendments, and for the completeness and accuracy of the information concerning him, her or it contained herein, but shall not be responsible for the completeness and accuracy of the information concerning the other entities or persons, except to the extent that he, she or it knows or has reason to believe that such information is inaccurate.

Date: February 9, 2023

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| | |
|:---|:---|
| **STICHTING AESCAP LIFE SCIENCES** | **STICHTING AESCAP LIFE SCIENCES** |
| **BY: PRIVIUM FUND MANAGEMENT B.V., ITS FUND MANAGER** | **BY: PRIVIUM FUND MANAGEMENT B.V., ITS FUND MANAGER** |
| By: | /s/ Patrick Johan Hendrik Krol |
| Name: | P.J.H. Krol |
| Title: | Portfolio Manager |
| **STICHTING AESCAP GENETICS** | **STICHTING AESCAP GENETICS** |
| **BY: PRIVIUM FUND MANAGEMENT B.V., ITS FUND MANAGER** | **BY: PRIVIUM FUND MANAGEMENT B.V., ITS FUND MANAGER** |
| By: | /s/ Patrick Johan Hendrik Krol |
| Name: | P.J.H. Krol |
| Title: | Portfolio Manager |
| **PRIVIUM FUND MANAGEMENT B.V.** | **PRIVIUM FUND MANAGEMENT B.V.** |
| By: | /s/ Patrick Johan Hendrik Krol |
| Name: | P.J.H. Krol |
| Title: | Portfolio Manager |
| **INSPIRATIONAL VISIONS B.V.** | **INSPIRATIONAL VISIONS B.V.** |
| By: | /s/ Patrick Johan Hendrik Krol |
| Name: | P.J.H. Krol |
| Title: | Managing Director |
| **PATRICK JOHAN HENDRIK KROL** | **PATRICK JOHAN HENDRIK KROL** |
|  | /s/ Patrick Johan Hendrik Krol |
| Dated: February 9, 2023 | Dated: February 9, 2023 |

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