# EDGAR Filing Document

**Accession Number:** 0002011932
**File Stem:** 0001420506-25-002106
**Filing Date:** 2025-8
**Character Count:** 10237
**Document Hash:** afcdacc940dfb2cdffd101a965071da4
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001420506-25-002106.hdr.sgml**: 20250814

**ACCESSION NUMBER**: 0001420506-25-002106

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20250630

**FILED AS OF DATE**: 20250814

**DATE AS OF CHANGE**: 20250814

**EFFECTIVENESS DATE**: 20250814

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Exome Asset Management LLC
- **CENTRAL INDEX KEY:** 0002011932

**ORGANIZATION NAME:**
- **EIN:** 825491108
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-23951
- **FILM NUMBER:** 251215826

**BUSINESS ADDRESS:**
- **STREET 1:** 330 MADISON AVENUE
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10017
- **BUSINESS PHONE:** 212-403-3900

**MAIL ADDRESS:**
- **STREET 1:** 330 MADISON AVENUE
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10017

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 06-30-2025

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** Exome Asset Management LLC<br>**Address:** 330 MADISON AVENUE<br>NEW YORK, NY 10017

**Form 13F File Number:** 028-23951

**CRD Number (if applicable):** 000304585

**SEC File Number (if applicable):** 801-121896

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** BRIANNE SHERGILL<br>**Title:** Chief Compliance Officer<br>**Phone:** 212-403-3909

**Signature, Place, and Date of Signing:**

BRIANNE SHERGILL Chief Compliance Officer  New York, NY  08-14-2025<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 64

**Form 13F Information Table Value Total:** $134501159

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

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|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| 10X GENOMICS INC | CL A COM | 88025U109 |  | 1895160 | 163658 | SH |  | SOLE |  | 163658 | 0 | 0 |
| 89BIO INC | COM | 282559103 |  | 2292243 | 233426 | SH |  | SOLE |  | 233426 | 0 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 |  | 2010799 | 93222 | SH |  | SOLE |  | 93222 | 0 | 0 |
| AKERO THERAPEUTICS INC | COM | 00973Y108 |  | 3125775 | 58579 | SH |  | SOLE |  | 58579 | 0 | 0 |
| ALTIMMUNE INC | PUT | 02155H950 |  | 414090 | 107000 | SH | Put | SOLE |  | 107000 | 0 | 0 |
| ALVOTECH | ORDINARY SHARES | L01800108 |  | 714753 | 78372 | SH |  | SOLE |  | 78372 | 0 | 0 |
| ANAPTYSBIO INC | COM | 032724106 |  | 333000 | 15000 | SH |  | SOLE |  | 15000 | 0 | 0 |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 |  | 1706766 | 98600 | SH |  | SOLE |  | 98600 | 0 | 0 |
| ARBUTUS BIOPHARMA CORP | COM | 03879J100 |  | 233246 | 75484 | SH |  | SOLE |  | 75484 | 0 | 0 |
| ASTRAZENECA PLC | SPONSORED ADR | 046353108 |  | 3933226 | 28362 | SH |  | SOLE |  | 28362 | 0 | 0 |
| BIOCRYST PHARMACEUTICALS INC | COM | 09058V103 |  | 1549032 | 172883 | SH |  | SOLE |  | 172883 | 0 | 0 |
| BRIDGEBIO PHARMA INC | COM | 10806X102 |  | 6715915 | 155533 | SH |  | SOLE |  | 155533 | 0 | 0 |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 |  | 1485550 | 73000 | SH |  | SOLE |  | 73000 | 0 | 0 |
| CENCORA INC | COM | 03073E105 |  | 1799100 | 6000 | SH |  | SOLE |  | 6000 | 0 | 0 |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 |  | 2193644 | 166944 | SH |  | SOLE |  | 166944 | 0 | 0 |
| COGENT BIOSCIENCES INC | COM | 19240Q201 |  | 3831585 | 533647 | SH |  | SOLE |  | 533647 | 0 | 0 |
| COMPASS PATHWAYS PLC | SPONSORED ADS | 20451W101 |  | 597923 | 213544 | SH |  | SOLE |  | 213544 | 0 | 0 |
| CORBUS PHARMACEUTICALS HLDGS | COM NEW | 21833P301 |  | 1913487 | 277317 | SH |  | SOLE |  | 277317 | 0 | 0 |
| CRINETICS PHARMACEUTICALS IN | COM | 22663K107 |  | 1803252 | 62700 | SH |  | SOLE |  | 62700 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 3826594 | 115817 | SH |  | SOLE |  | 115817 | 0 | 0 |
| DISC MEDICINE INC | COM | 254604101 |  | 3249414 | 61356 | SH |  | SOLE |  | 61356 | 0 | 0 |
| DYNE THERAPEUTICS INC | COM | 26818M108 |  | 1865282 | 195933 | SH |  | SOLE |  | 195933 | 0 | 0 |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 |  | 1631802 | 124470 | SH |  | SOLE |  | 124470 | 0 | 0 |
| ELEDON PHARMACEUTICALS INC | COM | 28617K101 |  | 309333 | 114145 | SH |  | SOLE |  | 114145 | 0 | 0 |
| ELEVATION ONCOLOGY INC | COM | 28623U101 |  | 40511 | 110353 | SH |  | SOLE |  | 110353 | 0 | 0 |
| ELI LILLY  CO | COM | 532457108 |  | 3642744 | 4673 | SH |  | SOLE |  | 4673 | 0 | 0 |
| ESTABLISHMENT LABS HLDGS INC | COM | G31249108 |  | 559501 | 13100 | SH |  | SOLE |  | 13100 | 0 | 0 |
| FULCRUM THERAPEUTICS INC | CALL | 359616909 |  | 137600 | 20000 | SH | Call | SOLE |  | 20000 | 0 | 0 |
| FULCRUM THERAPEUTICS INC | COM | 359616109 |  | 3061249 | 444949 | SH |  | SOLE |  | 444949 | 0 | 0 |
| GERON CORP | COM | 374163103 |  | 4814272 | 3414377 | SH |  | SOLE |  | 3414377 | 0 | 0 |
| GOSSAMER BIO INC | COM | 38341P102 |  | 1350539 | 1097999 | SH |  | SOLE |  | 1097999 | 0 | 0 |
| GUARDANT HEALTH INC | COM | 40131M109 |  | 5109391 | 98182 | SH |  | SOLE |  | 98182 | 0 | 0 |
| INSTIL BIO INC | COM NEW | 45783C200 |  | 337446 | 16200 | SH |  | SOLE |  | 16200 | 0 | 0 |
| INTUITIVE SURGICAL INC | COM NEW | 46120E602 |  | 3455001 | 6358 | SH |  | SOLE |  | 6358 | 0 | 0 |
| IONIS PHARMACEUTICALS INC | COM | 462222100 |  | 4785293 | 121116 | SH |  | SOLE |  | 121116 | 0 | 0 |
| ISHARES TR | PUT | 464287954 |  | 7352000 | 200000 | SH | Put | SOLE |  | 200000 | 0 | 0 |
| KARYOPHARM THERAPEUTICS INC | NOTE  3.000%10/1 | 48576UAA4 |  | 1523997 | 2000000 | SH |  | SOLE |  | 2000000 | 0 | 0 |
| LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 |  | 1032759 | 29100 | SH |  | SOLE |  | 29100 | 0 | 0 |
| LIQUIDIA CORPORATION | COM NEW | 53635D202 |  | 255430 | 20500 | SH |  | SOLE |  | 20500 | 0 | 0 |
| MBX BIOSCIENCES INC | COM | 55287L101 |  | 719697 | 63076 | SH |  | SOLE |  | 63076 | 0 | 0 |
| MEREO BIOPHARMA GROUP PLC | PUT | 589492957 |  | 39566 | 14600 | SH | Put | SOLE |  | 14600 | 0 | 0 |
| NATERA INC | COM | 632307104 |  | 3150731 | 18650 | SH |  | SOLE |  | 18650 | 0 | 0 |
| NEKTAR THERAPEUTICS | CALL | 640268906 |  | 1938000 | 75000 | SH | Call | SOLE |  | 75000 | 0 | 0 |
| NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | N62509109 |  | 662355 | 36574 | SH |  | SOLE |  | 36574 | 0 | 0 |
| PENUMBRA INC | COM | 70975L107 |  | 2309670 | 9000 | SH |  | SOLE |  | 9000 | 0 | 0 |
| PRAXIS PRECISION MEDICINES I | COM NEW | 74006W207 |  | 2481034 | 59002 | SH |  | SOLE |  | 59002 | 0 | 0 |
| REGENXBIO INC | COM | 75901B107 |  | 1855953 | 226060 | SH |  | SOLE |  | 226060 | 0 | 0 |
| REPLIMUNE GROUP INC | COM | 76029N106 |  | 3695989 | 397846 | SH |  | SOLE |  | 397846 | 0 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607100 |  | 1445000 | 2000000 | SH |  | SOLE |  | 2000000 | 0 | 0 |
| SCHOLAR ROCK HLDG CORP | COM | 80706P103 |  | 2987287 | 84339 | SH |  | SOLE |  | 84339 | 0 | 0 |
| SOLENO THERAPEUTICS INC | COM | 834203309 |  | 3488683 | 41641 | SH |  | SOLE |  | 41641 | 0 | 0 |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 |  | 1114651 | 53744 | SH |  | SOLE |  | 53744 | 0 | 0 |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 |  | 2887211 | 308298 | SH |  | SOLE |  | 308298 | 0 | 0 |
| TENET HEALTHCARE CORP | COM NEW | 88033G407 |  | 4752000 | 27000 | SH |  | SOLE |  | 27000 | 0 | 0 |
| TRAVERE THERAPEUTICS INC | COM | 89422G107 |  | 2268514 | 153278 | SH |  | SOLE |  | 153278 | 0 | 0 |
| TRAVERE THERAPEUTICS INC | CALL | 89422G907 |  | 1628000 | 110000 | SH | Call | SOLE |  | 110000 | 0 | 0 |
| ULTRAGENYX PHARMACEUTICAL IN | CALL | 90400D908 |  | 1363500 | 37500 | SH | Call | SOLE |  | 37500 | 0 | 0 |
| UNITEDHEALTH GROUP INC | COM | 91324P102 |  | 436758 | 1400 | SH |  | SOLE |  | 1400 | 0 | 0 |
| UNIVERSAL HLTH SVCS INC | CL B | 913903100 |  | 615910 | 3400 | SH |  | SOLE |  | 3400 | 0 | 0 |
| UNIVERSAL HLTH SVCS INC | CL B | 913903100 |  | 1213705 | 6700 | SH |  | SOLE |  | 6700 | 0 | 0 |
| VERA THERAPEUTICS INC | CL A | 92337R101 |  | 1807052 | 76700 | SH |  | SOLE |  | 76700 | 0 | 0 |
| VERASTEM INC | COM NEW | 92337C203 |  | 2489585 | 599900 | SH |  | SOLE |  | 599900 | 0 | 0 |
| VYNE THERAPEUTICS INC | COM | 92941V308 |  | 344801 | 208970 | SH |  | SOLE |  | 208970 | 0 | 0 |
| WAYSTAR HLDG CORP | COM | 946784105 |  | 1916803 | 46900 | SH |  | SOLE |  | 46900 | 0 | 0 |

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