# EDGAR Filing Document

**Accession Number:** 0000901832
**File Stem:** 0001104659-25-071432
**Filing Date:** 2025-7
**Character Count:** 161774
**Document Hash:** d47d5b861fd0dc2e8f8be3849921dc1c
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-25-071432.hdr.sgml**: 20250729

**ACCESSION NUMBER**: 0001104659-25-071432

**CONFORMED SUBMISSION TYPE**: 6-K

**PUBLIC DOCUMENT COUNT**: 49

**CONFORMED PERIOD OF REPORT**: 20250630

**FILED AS OF DATE**: 20250729

**DATE AS OF CHANGE**: 20250729

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** ASTRAZENECA PLC
- **CENTRAL INDEX KEY:** 0000901832
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** X0
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 6-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-11960
- **FILM NUMBER:** 251157612

**BUSINESS ADDRESS:**
- **STREET 1:** 1 FRANCIS CRICK AVENUE
- **STREET 2:** CAMBRIDGE BIOMEDICAL CAMPUS
- **CITY:** CAMBRIDGE
- **STATE:** X0
- **ZIP:** CB2 0AA
- **BUSINESS PHONE:** 011 44 20 7304 5000

**MAIL ADDRESS:**
- **STREET 1:** 1 FRANCIS CRICK AVENUE
- **STREET 2:** CAMBRIDGE BIOMEDICAL CAMPUS
- **CITY:** CAMBRIDGE
- **STATE:** X0
- **ZIP:** CB2 0AA

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ZENECA GROUP PLC
- **DATE OF NAME CHANGE:** 19930422

?xml version='1.0' encoding='ASCII'? ASTRAZENECA PLC_2025-06-30

------

**FORM 6-K**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**Report of Foreign Issuer**

**Pursuant to Rule 13a-16 or 15d-16 of**

**the Securities Exchange Act of 1934**

**For the month of July 2025**

**Commission File Number: 001-11960**

**AstraZeneca PLC**

**1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0AA England**

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.

Form 20-F ☒ Form 40-F ☐

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1): ☐

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7): ☐

Indicate by check mark whether the registrant by furnishing the information contained in this Form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.

---

| | |
|:---|:---|
| Yes ☐ | No ☒ |

---

If "Yes" is marked, indicate below the file number assigned to the Registrant in connection with Rule 12g3-2(b): 82-

------

![Graphic](azn-20250630x6k001.jpg)

29 July 2025

**AstraZeneca results: H1 and Q2 2025**

***Strong growth momentum continues with excellent R&D pipeline delivery in the year-to-date***

**Revenue and EPS summary**

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | | **% Change** | **% Change** | | **% Change** | **% Change** |
|  | **H1 2025**<br>**$m** | **Actual** | **CER**<sup>1</sup> | **Q2 2025**<br>**$m** | **Actual** | **CER** |
| *- Product Sales* | *26670* | *8* | *10* | *13795* | *11* | *10* |
| *- Alliance Revenue* | *1293* | *38* | *38* | *654* | *36* | *35* |
| Product Revenue<sup>2</sup> | 27963 | 9 | 11 | 14449 | 12 | 11 |
| Collaboration Revenue | 82 | 68 | 66 | 8 | >2x | >2x |
| **Total Revenue** | 28045 | 9 | 11 | 14457 | 12 | 11 |
| **Reported EPS ($)** | 3.46 | 31 | 32 | 1.58 | 27 | 31 |
| **Core**<sup>3</sup> **EPS ($)** | 4.66 | 16 | 17 | 2.17 | 10 | 12 |

---

**Key performance elements for H1 2025**

(Growth numbers at constant exchange rates)

---

| | |
|:---|:---|
| ‒ | Total Revenue up 11% to $28,045m, driven by double-digit growth in Oncology and BioPharmaceuticals |

---

---

| | |
|:---|:---|
| ‒ | Growth in Total Revenue across all major geographic regions  |

---

---

| | |
|:---|:---|
| ‒ | Core Operating profit increased 13% |

---

---

| | |
|:---|:---|
| ‒ | Core EPS increased 17% to $4.66 |

---

‒ 12 positive Phase III readouts and 19 approvals in major regions

---

| | |
|:---|:---|
| ‒ | Interim dividend increased 3% to $1.03 (76.7 pence, 9.81 SEK) |

---

**Pascal Soriot, Chief Executive Officer, AstraZeneca, said:**

*"Our strong momentum in revenue growth continued through the first half of the year and the delivery from our broad and diverse pipeline has been excellent, with 12 positive key Phase III trial readouts including for baxdrostat, gefurulimab, and Tagrisso in just the past few weeks.*

*As we enter our next phase of growth, we have pledged $50 billion to continue to grow in the US, which includes the largest manufacturing investment in AstraZeneca's history, set for Virginia. This landmark investment reflects not only America's importance but also our confidence in our innovative medicines to transform global health and power AstraZeneca's ambition to deliver $80 billion revenue by 2030."*

**Guidance**

AstraZeneca reiterates its Total Revenue and Core EPS guidance<sup>4</sup> for FY 2025 at CER, based on the average foreign exchange rates through 2024.

------

**Total Revenue** is expected to increase by a **high single-digit** percentage

**Core EPS** is expected to increase by a **low double-digit** percentage

------

The Core Tax rate is expected to be between 18-22%

*If foreign exchange rates for July 2025 to December 2025 were to remain at the average rates seen in June 2025, it is anticipated that FY 2025 Total Revenue growth and Core EPS growth would be broadly similar to the growth at CER (previously a low single-digit percentage adverse impact was anticipated)*

![Graphic](azn-20250630x6k001.jpg)

---

| | |
|:---|:---|
| **Contents** |  |
| [Results highlights](#Resultshighlights_119411) | 4 |
| [Revenue drivers](#Revenuedrivers_583945) | 8 |
| [R&D progress](#RDprogress_120000) | 15 |
| [Sustainability](#Sustainability_166332) | 20 |
| [Operating and financial review](#Operatingandfinancialreview_949271) | 21 |
| [Financial performance](#Financialperformance_810140) | 23 |
| [Interim financial statements](#Interimfinancialstatements_854197) | 29 |
| [Responsibility statement of the directors in respect of the half-yearly financial report](#Responsibilitystatementofthedirectors_45) | 34 |
| [Independent review report to AstraZeneca PLC](#IndependentreviewreporttoAstraZenecaPLC_) | 35 |
| [Notes to the Interim financial statements](#NotestotheInterimfinancialstatements_202) | 37 |
| [Other shareholder information](#Othershareholderinformation_413834) | 48 |
| [Glossary](#Glossary_79878) | 50 |

---

**Tables**

---

| | |
|:---|:---|
| [Table 1: Milestones achieved since the prior results announcement](#Table1_145051)  | 4 |
| [Table 2: Key elements of financial performance: Q2 2025](#Table2_623360) | 5 |
| [Table 3: Product Revenue by medicine](#Table3_371751)  | 8 |
| [Table 4: Collaboration Revenue](#Table4_545708) | 9 |
| [Table 5: Total Revenue by Therapy Area](#Table5_371706) | 9 |
| [Table 6: Total Revenue by region](#Table6_597645) | 9 |
| [Table 7: Reported Profit and Loss](#Table7_817028) | 23 |
| [Table 8: Reconciliation of Reported Profit before tax to EBITDA](#Table8_18957) | 23 |
| [Table 9: Reconciliation of Reported to Core financial measures: H1 2025](#Table9_648429) | 23 |
| [Table 10: Reconciliation of Reported to Core financial measures: Q2 2025](#Table10_757955) | 24 |
| [Table 11: Cash Flow summary: H1 2025](#Table11_883266) | 25 |
| [Table 12: Net debt summary](#Table12_213021) | 26 |
| [Table 13: Obligor group summarised Statement of comprehensive income: H1 2025](#Table13_260788) | 27 |
| [Table 14: Obligor group summarised Statement of financial position](#Table14_384790) | 27 |
| [Table 15: Currency sensitivities](#Table15_597166) | 28 |
| [Table 16: Condensed consolidated statement of comprehensive income: H1 2025](#Table16_152221) | 29 |
| [Table 17: Condensed consolidated statement of comprehensive income: Q2 2025](#Table17_664655) | 30 |
| [Table 18: Condensed consolidated statement of financial position](#Table18_600740) | 31 |
| [Table 19: Condensed consolidated statement of changes in equity](#Table19_403707) | 32 |
| [Table 20: Condensed consolidated statement of cash flows: H1 2025](#Table20_236718) | 33 |
| [Table 21: Net debt](#Table21_362334) | 38 |
| [Table 22: Contingent consideration](#Table22_424909) | 39 |
| [Table 23: Product Sales year-on-year analysis: H1 2025](#Table23_158326) | 45 |
| [Table 24: Product Sales year-on-year analysis: Q2 2025 (Unreviewed)](#Tables24_541999) | 46 |
| [Table 25: Alliance Revenue: H1 2025](#Table25_442936) | 47 |
| [Table 26: Collaboration Revenue: H1 2025](#Table26_335203) | 47 |
| [Table 27: Other operating income and expense: H1 2025](#Table27_257584) | 47 |

---

![Graphic](azn-20250630x6k001.jpg)

**Results highlights**

**Table 1. Milestones achieved since the prior results announcement**

**Phase III and other registrational data readouts**

---

| | | | |
|:---|:---|:---|:---|
| **Medicine** | **Trial** | **Indication** | **Event** |
| *Enhertu* | DESTINY-Breast11 | High-risk HER2+ early breast cancer (neoadjuvant) | Primary endpoint met |
| *Imfinzi* | POTOMAC | High-risk non-muscle invasive bladder cancer | Primary endpoint met |
| *Tagrisso* | FLAURA2 | 1L *EGFR*m NSCLC | Secondary endpoint met (OS) |
| baxdrostat | BaxHTN | Uncontrolled or treatment resistant hypertension | Primary endpoint met |
| *Breztri* | KALOS/LOGOS | Uncontrolled asthma | Primary endpoint met |
| *Fasenra* | NATRON | HES | Primary endpoint met |
| *Saphnelo* | AZALEA | SLE (China) | Primary endpoint met |
| anselamimab | CARES (301/2) | Light chain amyloidosis | Primary endpoint not met |
| gefurulimab | PREVAIL | Generalised myasthenia gravis | Primary endpoint met |

---

**Regulatory approvals**

---

| | | | |
|:---|:---|:---|:---|
| **Medicine** | **Trial** | **Indication** | **Region** |
| *Calquence* | ECHO | 1L MCL | EU |
| *Calquence* | ACE-LY-004 | Relapsed/refractory MCL | EU |
| *Calquence* | AMPLIFY | 1L CLL (fixed duration) | EU |
| *Datroway* | TROPION-Lung05/ TROPION-Lung01 | 2L+ *EGFR*m NSCLC | US |
| *Imfinzi* | ADRIATIC | Limited-stage SCLC | CN |
| *Imfinzi* | NIAGARA | MIBC | EU |
| *Tagrisso* | LAURA | Locally advanced/unresectable *EGFR*m NSCLC | JP |
| *Orpathys* + *Tagrisso* | SACHI | Locally advanced/metastatic 2L+ *EGFR*m MET+ NSCLC | CN |

---

**Regulatory submissions or acceptances\* in major regions**

---

| | | | |
|:---|:---|:---|:---|
| **Medicine** | **Trial** | **Indication** | **Region** |
| *Calquence* | AMPLIFY | 1L CLL (fixed duration) | US |
| *Enhertu* | DESTINY-PanTumor02 | 2L+ unresectable / metastatic HER2+ solid tumours | JP |
| *Enhertu* | DESTINY-Gastric04 | 2L HER2+ gastric cancer | CN, JP |
| *Imfinzi* | MATTERHORN | Resectable early-stage gastric and GEJ cancers | US |
| camizestrant | SERENA-6 | *ESR1*m HR+ HER2- aBC | US, EU, JP |

---

*\* US, EU and China regulatory submissions denotes filing acceptance*

**Other pipeline updates**

For recent trial starts and anticipated timings of key trial readouts, please refer to the Clinical Trials Appendix, available on www.astrazeneca.com/investor-relations.html.

![Graphic](azn-20250630x6k001.jpg)

**Table 2: Key elements of financial performance: Q2 2025**

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| For the **quarter** | **Reported** | **Change** | **Change** | **Core** | **Change** | **Change** |  |
| ended 30 June | **$m** | **Act** | **CER** | **$m** | **Act** | **CER** |  |
| Product Revenue | 14449 | 12  | 11  | 14449  | 12  | 11 | <br>● See Tables 3, 23, 24 and 25 for medicine details of Product Revenue, Product Sales and Alliance Revenue<br>|
| Collaboration Revenue | 8 | >2x  | >2x  | 8  | >2x  | >2x | <br>● See Tables 4 and 26 for details of Collaboration Revenue<br>|
| Total Revenue | 14457 | 12  | 11  | 14457  | 12  | 11 | <br>● See Tables 5 and 6 for Total Revenue by Therapy Area and by region<br>|
| Gross Margin (%) | 83 |  |  | 82 | (1pp) |  | <br>**-**<br>Growth of partnered medicines<br>● Variations in Gross Margin can be expected between periods due to various factors, including fluctuations in foreign exchange rates, product seasonality and Collaboration Revenue<br>● See 'Reporting changes' below for the definition of Gross Margin<sup>5</sup> |
| R&D expense | 3548 | 18 | 16  | 3453  | 20  | 18  | <br>● Core R&D: 24% of Total Revenue<br>+<br>Accelerated recruitment in ongoing Phase III trials<br>+<br>Investments in transformative technologies such as cell therapy and radioconjugates<br>+<br>Positive data read-outs for high-value pipeline opportunities that have ungated late-stage trials<br>+<br>Addition of BD related R&D<br>|
| SG&A expense | 4864 | (1) | (2) | 3802  | 2  | 1  | <br>● Core SG&A: 26% of Total Revenue<br>|
| Other operating income and expense<sup>6</sup> | 79 | 30  | 33  | 71  | 19  | 23  |  |
| Operating Profit | 3508 | 28  | 32  | 4584  | 12  | 14  |  |
| Operating Margin (%) | 24 | 3pp  | 4pp  | 32  | —  | 1pp  |  |
| Net finance expense | 371 | 8  | 10  | 303 | 6  | 9  | <br>+<br>Debt issued in 2024 at higher interest rates<br>|
| Tax rate (%) | 22 | 2pp  | 2pp  | 21  | 2pp  | 2pp  | <br>● Variations in the tax rate can be expected between periods<br>|
| EPS ($) | 1.58 | 27  | 31  | 2.17  | 10  | 12  |  |

---

*For monetary values the unit of change is percent; for Gross Margin, Operating Margin and Tax rate the unit of change is percentage points.*

*In the expense commentary above, the plus and minus symbols denote the directional impact of the item being discussed, e.g. a '+' symbol beside an R&D expense comment indicates that the item resulted in an increase in the R&D expense relative to the prior year period.*

**Corporate and business development** 

**CSPC**

In June 2025, AstraZeneca entered a strategic research collaboration with Shijiazhuang City-based CSPC Pharmaceuticals Group Limited to discover and develop pre-clinical candidates for multiple targets with the potential to treat diseases across chronic indications, including a pre-clinical small molecule oral therapy for immunological diseases. CSPC's research will utilise its AI-driven, dual-engine efficient drug discovery platform.

CSPC will receive an upfront payment of $110m, of which $60m has been capitalised as an Intangible asset, and is also eligible to receive up to $1.62bn in potential development milestone payments and up to $3.6bn in sales milestone payments, plus potential single-digit royalties based on annual net sales of the products.

AstraZeneca will have rights to exercise options for exclusive licenses to develop and commercialise worldwide candidates identified under this agreement.

**EsoBiotec**

In May 2025, AstraZeneca completed the acquisition of EsoBiotec, a biotechnology company pioneering in vivo cell therapies that has demonstrated promising early clinical activity. The EsoBiotec Engineered NanoBody Lentiviral (ENaBL) platform uses highly targeted lentiviruses to deliver genetic instructions to specific immune cells, with potential use in oncology and immune-mediated diseases.

AstraZeneca has acquired all outstanding equity of EsoBiotec for a total consideration of up to $1bn, on a cash and debt free basis. This includes an initial payment of $403m, and up to $575m in contingent consideration based on development and regulatory milestones.

![Graphic](azn-20250630x6k001.jpg)

**US investment plans**

In July 2025, AstraZeneca announced plans to invest $50bn in US manufacturing and R&D by 2030.

The cornerstone of this landmark investment is a new multi-billion dollar US manufacturing facility that will produce drug substances for the Company's innovative weight management and metabolic portfolio, including oral GLP-1, baxdrostat, oral PCSK9 and combination small molecule products.

The drug substance facility, planned to be in the Commonwealth of Virginia, would be AstraZeneca's largest single manufacturing investment in the world. The facility will leverage AI, automation, and data analytics to optimise production.

**Sustainability highlights**

AstraZeneca introduced an updated Sustainability strategy which focuses on the Company's sustainability impact and how it does business. This strategy evolution recognises the connection between business growth and the need to address the major health challenges of our time, and aims to support the health of people, society and the planet.

**Reporting calendar** 

The Company intends to publish its 9M and Q3 2025 results on 6 November 2025.

**Conference call**

A conference call and webcast for investors and analysts will begin today, 29 July 2025, at 14:00 UK time. Details can be accessed via astrazeneca.com.

**Reporting changes since FY 2024** 

**Product Revenue**

Effective 1 January 2025, the Group has updated the presentation of Total Revenue on the face of the Statement of Comprehensive Income to include a new subtotal 'Product Revenue' representing the summation of Product Sales and Alliance Revenue.

Product Revenue and Collaboration Revenue form Total Revenue.

Product Sales and Alliance Revenue will continue to be presented separately, with the new subtotal providing additional aggregation of revenue types with similar characteristics, reflecting the growing importance of Alliance Revenue.

Full descriptions of Product Sales, Alliance Revenue and Collaboration Revenue are included from page 152 of the Group's Annual Report and Form 20-F Information 2024.

**Gross Margin**

Effective 1 January 2025, the Group has replaced the measure of 'Product Sales Gross Margin' with the measure of 'Gross Margin'. Previously, the measure excluded margin related to Alliance Revenue and Collaboration Revenue. The new measure is calculated using Gross profit as a percentage of Total Revenue, thereby encompassing all revenue categories, and is intended to provide a more comprehensive measure of total performance.

![Graphic](azn-20250630x6k001.jpg)

**Notes**

&nbsp;&nbsp;&nbsp;&nbsp;1. Constant exchange rates. The differences between Actual Change and CER Change are due to foreign exchange movements between periods in 2025 vs. 2024. CER financial measures are not accounted for according to generally accepted accounting principles (GAAP) because they remove the effects of currency movements from Reported results.

&nbsp;&nbsp;&nbsp;&nbsp;2. Effective 1 January 2025, the Group has updated its presentation of Total Revenue, adding a new subtotal of Product Revenue, the sum of Product Sales and Alliance revenue. For further details, see Note 1: 'Basis of preparation and accounting policy' in the Notes to the Interim Financial Statements.

&nbsp;&nbsp;&nbsp;&nbsp;3. Core financial measures are adjusted to exclude certain items. The differences between Reported and Core measures are primarily due to costs relating to the amortisation of intangibles, impairments, legal settlements and restructuring charges. A full reconciliation between Reported EPS and Core EPS is provided in Table 9 in the Financial Performance section of this document.

&nbsp;&nbsp;&nbsp;&nbsp;4. The Company is unable to provide guidance on a Reported basis because it cannot reliably forecast material elements of the Reported results, including any fair value adjustments arising on acquisition-related liabilities, intangible asset impairment charges and legal settlement provisions. Please refer to the cautionary statements section regarding forward-looking statements at the end of this announcement.

&nbsp;&nbsp;&nbsp;&nbsp;5. Effective 1 January 2025, the Group has updated its presentation of Gross Margin. For further details, see Note 1: 'Basis of preparation and accounting policy' in the Notes to the Interim Financial Statements

&nbsp;&nbsp;&nbsp;&nbsp;6. Income from disposals of assets and businesses, where the Group does not retain a significant ongoing economic interest, is recorded in Other operating income and expense in the Group's financial statements.

![Graphic](azn-20250630x6k001.jpg)

**Revenue drivers**

**Table 3: Product Revenue by medicine**

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
|  | | | **% Change** | **% Change** | | | **% Change** | **% Change** |
|  | **H1 2025**<br>**$m** | <br>**% Total** | **Actual** | **CER** | **Q2 2025**<br>**$m** | &nbsp;&nbsp;&nbsp;&nbsp;<br>**% Total** | **Actual** | **CER** |
| *Tagrisso* | 3488 | 12 | 9 | 10 | 1810 | 13 | 13 | 12 |
| *Imfinzi* | 2716 | 10 | 20 | 21 | 1455 | 10 | 27 | 26 |
| *Calquence* | 1634 | 6 | 8 | 9 | 872 | 6 | 10 | 10 |
| *Lynparza* | 1564 | 6 | 8 | 9 | 838 | 6 | 13 | 11 |
| *Enhertu* | 1262 | 5 | 35 | 38 | 666 | 5 | 41 | 42 |
| *Zoladex* | 587 | 2 | 4 | 6 | 294 | 2 | 4 | 5 |
| *Truqap* | 302 | 1 | >2x | >2x | 170 | 1 | 84 | 84 |
| *Imjudo* | 170 | 1 | 25 | 25 | 89 | 1 | 20 | 18 |
| *Datroway* | 14 |  | n/m | n/m | 11 |  | n/m | n/m |
| Other Oncology | 217 | 1 | (10) | (8) | 107 | 1 | (12) | (13) |
| **Oncology Product Revenue** | **11954** | **43** | **15** | **16** | **6312** | **44** | **18** | **18** |
| *Farxiga* | 4209 | 15 | 11 | 13 | 2151 | 15 | 11 | 10 |
| *Crestor* | 636 | 2 | 8 | 10 | 320 | 2 | 9 | 9 |
| *Brilinta* | 520 | 2 | (22) | (21) | 215 | 1 | (37) | (38) |
| *Lokelma* | 328 | 1 | 31 | 32 | 175 | 1 | 29 | 27 |
| *Seloken* | 309 | 1 | (2) | 2 | 148 | 1 | (2) | 1 |
| roxadustat | 152 | 1 | (9) | (8) | 73 | 1 | (18) | (18) |
| *Wainua* | 84 |  | >4x | >4x | 44 |  | >2x | >2x |
| Other CVRM | 274 | 1 | (27) | (26) | 138 | 1 | (27) | (28) |
| **CVRM Product Revenue** | **6512** | **23** | **6** | **7** | **3264** | **23** | **3** | **3** |
| *Symbicort* | 1438 | 5 | (4) | (2) | 715 | 5 | (1) | (1) |
| *Fasenra* | 920 | 3 | 18 | 18 | 502 | 3 | 19 | 18 |
| *Breztri* | 583 | 2 | 28 | 29 | 283 | 2 | 21 | 20 |
| *Tezspire* | 483 | 2 | 73 | 73 | 267 | 2 | 66 | 65 |
| *Pulmicort* | 264 | 1 | (30) | (28) | 106 | 1 | (32) | (32) |
| *Saphnelo* | 304 | 1 | 49 | 49 | 167 | 1 | 49 | 48 |
| *Airsupra* | 70 |  | >3x | >3x | 42 |  | >2x | >2x |
| Other R&I | 172 | 1 | (5) | (5) | 68 |  | (19) | (20) |
| **R&I Product Revenue** | **4234** | **15** | **12** | **13** | **2150** | **15** | **13** | **12** |
| *Beyfortus* | 238 | 1 | >2x | >2x | 126 | 1 | >3x | >3x |
| *Synagis* | 162 | 1 | (36) | (33) | 49 |  | (39) | (37) |
| *FluMist* | 10 |  | 20 | 16 | 10 |  | >5x | >5x |
| Other V&I | 1 |  | (91) | (91) |  |  | (78) | (78) |
| **V&I Product Revenue** | **411** | **1** | **17** | **18** | **185** | **1** | **56** | **54** |
| *Ultomiris* | 2228 | 8 | 23 | 24 | 1177 | 8 | 25 | 23 |
| *Soliris* | 974 | 3 | (32) | (30) | 530 | 4 | (24) | (22) |
| *Strensiq* | 746 | 3 | 14 | 15 | 395 | 3 | 16 | 15 |
| *Koselugo* | 275 | 1 | 11 | 13 | 137 | 1 | 20 | 18 |
| Other Rare Disease | 113 |  | 12 | 14 | 55 |  | 16 | 14 |
| **Rare Disease Product Revenue** | **4336** | **16** | **2** | **3** | **2294** | **16** | **7** | **7** |
| *Nexium* | 434 | 2 | (8) | (5) | 201 | 1 | (11) | (11) |
| Others | 82 |  | (20) | (20) | 43 |  | (12) | (13) |
| **Other Medicines Product Revenue** | **516** | **2** | **(10)** | **(8)** | **244** | **2** | **(11)** | **(11)** |
| **Product Revenue** | **27963** | **100** | **9** | **11** | **14449** | **100** | **12** | **11** |
| ***Alliance Revenue included above:*** |  |  |  |  |  |  |  |  |
| *Enhertu* | 834 | 3 | 22 | 24 | 436 | 3 | 27 | 27 |
| *Tezspire* | 285 | 1 | 58 | 58 | 155 | 1 | 50 | 50 |
| *Beyfortus* | 109 |  | >4x | >3x | 27 |  | >4x | >3x |
| *Datroway* | 14 |  | n/m | n/m | 10 |  | n/m | n/m |
| Other Alliance Revenue | 51 |  | 4 | 2 | 26 |  | (11) | (11) |
| ***Alliance Revenue*** | **1293** | **5** | **38** | **38** | **654** | **5** | **36** | **35** |

---

![Graphic](azn-20250630x6k001.jpg)

**Table 4: Collaboration Revenue**

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | | **% Change** | **% Change** | | **% Change** | **% Change** |
|  | **H1 2025**<br>**$m** | **Actual** | **CER** | **Q2 2025**<br>**$m** | **Actual** | **CER** |
| *Farxiga*: sales milestones | 77 | 57 | 56 | 3 | (36) | (38) |
| Others | 5 | n/m | n/m | 5 | n/m | n/m |
| **Collaboration Revenue** | **82** | **68** | **66** | **8** | **>2x** | **>2x** |

---

**Table 5: Total Revenue by Therapy Area**

---

| | | | | | | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
|  | |  | |  | **% Change** | **% Change** | **% Change** | |  | |  | **% Change** | **% Change** | **% Change** |
|  | **H1 2025**<br>**$m** |  | <br>**% Total** |  | **Actual** |  | **CER** | **Q2 2025**<br>**$m** |  | <br>**% Total** |  | **Actual** |  | **CER** |
| Oncology | 11955 |  | 43 |  | 15 |  | 16 | 6312 |  | 44 |  | 18 |  | 18 |
| *CVRM* | *6588* |  | *23* |  | *6* |  | *8* | *3266* |  | *23* |  | *3* |  | *3* |
| *R&I* | *4234* |  | *15* |  | *12* |  | *13* | *2150* |  | *15* |  | *13* |  | *12* |
| *V&I* | *411* |  | *1* |  | *17* |  | *18* | *185* |  | *1* |  | *56* |  | *54* |
| BioPharmaceuticals | 11232 |  | 40 |  | 8 |  | 10 | 5601 |  | 39 |  | 8 |  | 7 |
| Rare Disease | 4336 |  | 15 |  | 2 |  | 3 | 2294 |  | 16 |  | 7 |  | 7 |
| Other Medicines | 522 |  | 2 |  | (9) |  | (7) | 250 |  | 2 |  | (9) |  | (9) |
| **Total Revenue** | **28045** |  | **100** |  | **9** |  | **11** | **14457** |  | **100** |  | **12** |  | **11** |

---

**Table 6: Total Revenue by region**

---

| | | | | | | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
|  | |  | |  | **% Change** | **% Change** | **% Change** | |  | |  | **% Change** | **% Change** | **% Change** |
|  | **H1 2025**<br>**$m** |  | <br>**% Total** |  | **Actual** |  | **CER** | **Q2 2025**<br>**$m** |  | <br>**% Total** |  | **Actual** |  | **CER** |
| US | 11970 |  | 43 |  | 12 |  | 12 | 6323 |  | 44 |  | 13 |  | 14 |
| *Emerging Markets ex. China* | 4182 |  | 15 |  | 12 |  | 19 | 2043 |  | 14 |  | 16 |  | 21 |
| *China* | *3515* |  | *13* |  | *4* |  | *5* | *1710* |  | *12* |  | *5* |  | *5* |
| Emerging Markets | *7697* |  | *27* |  | *8* |  | *12* | *3754* |  | *26* |  | *11* |  | *13* |
| Europe | 5825 |  | 21 |  | 9 |  | 8 | 3066 |  | 21 |  | 12 |  | 8 |
| Established ROW | 2554 |  | 9 |  | 5 |  | 5 | 1315 |  | 9 |  | 5 |  | 2 |
| **Total Revenue** | **28045** |  | **100** |  | **9** |  | **11** | **14457** |  | **100** |  | **12** |  | **11** |

---

**Total Revenue by Medicine**

**Oncology**

***Tagrisso***

---

| | | | | |
|:---|:---|:---|:---|:---|
| **H1 2025** | **Total** | **% Change** | **% Change** | · Strong demand growth across all indications and key regions, leading <br>|
| **$m** | **Revenue** | **Actual** | **CER** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;combination in 1L NSCLC (FLAURA2) |
| US | 1439  | 12  | 12  | · Underlying demand growth more than offset Medicare Part D redesign<br>|
| Emerging Markets | 1008  | 10  | 13  |  |
| Europe | 658  | 5  | 5  | · Demand growth partially offset by pricing pressure in certain major markets<br>|
| Established RoW | 383  | 3  | 3  | · Demand growth offset by seasonal variability in Japan in Q1 2025<br>|
| **Total** | **3488**  | **9**  | **10**  |  |

---

![Graphic](azn-20250630x6k001.jpg)

***Imfinzi***

---

| | | | | |
|:---|:---|:---|:---|:---|
| **H1 2025** | **Total** | **% Change** | **% Change** | · Strong growth from new launch indications in bladder cancer <br>|
| **$m** | **Revenue** | **Actual** | **CER** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(NIAGARA) and lung cancer (ADRIATIC, AEGEAN) |
| US | 1572  | 31  | 31  | · Demand growth from new launches, further growth in ES-SCLC (CASPIAN)<br>|
| Emerging Markets | 294  | 20  | 28  | ● Increased demand in GI and new launches in lung cancer<br>|
| Europe | 537  | 17  | 17  | · Growth from GI indications and early momentum from lung cancer launches<br>|
| Established RoW | 313  | (11) | (11) | · Mandatory price reductions in Japan in Feb 2024 (25%), and Aug 2024 (11%), increased competition in BTC<br>|
| **Total** | **2716**  | **20**  | **21**  |  |

---

***Calquence***

---

| | | | | |
|:---|:---|:---|:---|:---|
| **H1 2025** | **Total** | **% Change** | **% Change** | · Growth from sustained BTKi leadership in front-line CLL (ELEVATE-TN)<br>|
| **$m** | **Revenue** | **Actual** | **CER** |  |
| US | 1090  | 4  | 4  | · Demand growth driven by increased share of new starts in CLL, 1L MCL (ECHO) launch and improved affordability offsetting Medicare Part D redesign and discounts to secure preferential formulary placement<br>|
| Emerging Markets | 103  | 36  | 49  |  |
| Europe | 368  | 15  | 15  |  |
| Established RoW | 73  | 12  | 15  |  |
| **Total** | **1634**  | **8**  | **9**  |  |

---

***Lynparza***

---

| | | | | |
|:---|:---|:---|:---|:---|
| **H1 2025** | **Total** | **% Change** | **% Change** | · Sustained global PARP inhibitor market leadership across four tumour <br>|
| **$m** | **Revenue** | **Actual** | **CER** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;types (ovarian, breast, prostate, pancreatic) |
| US | 689  | 14  | 14  | · Share gains across breast and prostate indications<br>|
| Emerging Markets | 323  | 1  | 4  | ● Affected by generic launches in China in Q4 2024<br>|
| Europe | 425  | 7  | 6  | ● Launches in breast and prostate cancers (OlympiA and PROpel)<br>|
| Established RoW | 127  | 1  | 2  | ● Gains in 1L ovarian cancer offset by lower testing rate in prostate cancer<br>|
| **Total** | **1564**  | **8**  | **9**  |  |

---

***Enhertu***

Combined sales of *Enhertu*, recorded by Daiichi Sankyo and AstraZeneca, amounted to $2,289m in H1 2025 (H1 2024: $1,772m). US in-market sales, recorded by Daiichi Sankyo, amounted to $1,128m in H1 2025 (H1 2024: $865m). AstraZeneca's European revenue includes a mid single-digit percentage royalty on Daiichi Sankyo's sales in Japan, recorded as Alliance Revenue.

---

| | | | | |
|:---|:---|:---|:---|:---|
| **H1 2025** | **Total** | **% Change** | **% Change** | · Standard of care in HER2-positive (DESTINY-Breast03) and HER2-low <br>|
| **$m** | **Revenue** | **Actual** | **CER** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(DESTINY-Breast04) metastatic breast cancer, early uptake in other cancers |
| US | 543  | 31  | 31  | · Accelerating uptake in chemotherapy naïve HER2-low and - ultralow breast cancer (DESTINY-Breast06)<br>|
| Emerging Markets | 365  | 63  | 72  | ● Rapid adoption post-NRDL enlistment of HER2-positive and HER2-low breast cancer from 1 January 2025<br>|
| Europe | 312  | 19  | 19  | ● Early launch uptake in chemotherapy naïve HER2-low breast cancer<br>|
| Established RoW | 42  | 35  | 41  |  |
| **Total** | **1262**  | **35**  | **38**  |  |

---

![Graphic](azn-20250630x6k001.jpg)

**Other Oncology medicines**

---

| | | | | |
|:---|:---|:---|:---|:---|
| | | **% Change** | **% Change** |  |
| **H1 2025**<br>**$m** | **Total**<br>**Revenue** | **Actual** | **CER** |  |
| *Zoladex* | 588  | 4  | 6  | ● Growth across Emerging Markets<br>|
| *Truqap* | 302  | >2x  | >2x  | ● Demand growth in second-line biomarker-altered population<br>|
| *Imjudo*  | 170  | 25  | 25  | ● Continued growth driven by lung (POSEIDON) and HCC (HIMALAYA) <br>|
| *Datroway* | 14  | n/m | n/m | ● Uptake from breast cancer following launch in the US <br>|
| Other Oncology | 217  | (10) | (8) | ● *Faslodex* generic erosion across markets<br>|

---

*Other Oncology includes $16m of Total Revenue from Orpathys, partnered with HUTCHMED.*

**BioPharmaceuticals – CVRM**

***Farxiga***

---

| | | | | |
|:---|:---|:---|:---|:---|
| **H1 2025** | **Total** | **% Change** | **% Change** | ● Growth driven by HF and CKD indications, SGLT2 class growth <br>|
| **$m** | **Revenue** | **Actual** | **CER** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;supported by cardiorenal guidelines |
| US | 803  | (8) | (8) | ● Q1 2024 benefitted from launch of authorised generic<br>|
| Emerging Markets | 1730  | 17  | 23  | ● Continued strong growth despite generic competition in some markets <br>|
| Europe | 1448  | 17  | 17  | ● Continued strong class growth and market share gains<br>|
| Established RoW | 304  | 17  | 17  | ● Sales milestone of $74m from partner in Japan in Q1 2025<br>|
| **Total** | **4285**  | **12**  | **14**  |  |

---

**Other CVRM medicines**

---

| | | | | |
|:---|:---|:---|:---|:---|
| | | **% Change** | **% Change** |  |
| **H1 2025**<br>**$m** | **Total**<br>**Revenue** | **Actual** | **CER** |  |
| *Crestor* | 636  | 8  | 10  | ● Continued sales growth driven by Emerging Markets<br>|
| *Brilinta* | 520  | (22) | (21) | ● Decline driven by generic entry in the US and Europe in Q2 2025<br>|
| *Seloken* | 309  | (2) | 2  | ● Majority of revenue driven by Emerging Markets<br>|
| *Lokelma* | 328  | 31  | 32  | ● Strong growth in all major regions<br>|
| *roxadustat* | 152  | (9) | (8) | ● Decline driven by generic competition<br>|
| *Wainua* | 84  | >4x  | >4x  | ● Majority of revenue from US, first launches in ex-US markets in Q2 2025<br>|
| Other CVRM | 274  | (27) | (26) |  |

---

**BioPharmaceuticals – R&I**

***Symbicort***

---

| | | | | |
|:---|:---|:---|:---|:---|
| **H1 2025** | **Total** | **% Change** | **% Change** | ● Global market leader in a stable ICS/LABA class, treating <br>|
| **$m** | **Revenue** | **Actual** | **CER** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;COPD and asthma |
| US | 598  | -  | -  | ● Resilient demand for authorised generic <br>|
| Emerging Markets | 400  | (11) | (8) | ● China affected by ICS/LABA class erosion in COPD in favour of triple therapy<br>|
| Europe | 272  | (5) | (5) | ● Continued generic erosion <br>|
| Established RoW | 168  | 7  | 10  |  |
| **Total** | **1438**  | **(4)** | **(2)** |  |

---

![Graphic](azn-20250630x6k001.jpg)

***Fasenra***

---

| | | | | |
|:---|:---|:---|:---|:---|
| **H1 2025** | **Total** | **% Change** | **% Change** | ● Expanded severe eosinophilic asthma market share leadership in IL-5 <br>|
| **$m** | **Revenue** | **Actual** | **CER** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;class, further fuelled by first wave market launches for EGPA indication |
| US | 556  | 16  | 16  | ● Sustained double-digit volume growth with expanded class leadership<br>|
| Emerging Markets | 52  | 26  | 32  | ● Asthma launch momentum across key markets<br>|
| Europe | 229  | 19  | 19  | ● Sustained leadership in severe eosinophilic asthma<br>|
| Established RoW | 83  | 19  | 20  | ● Strong growth supported by recent EGPA launch in Japan<br>|
| **Total** | **920**  | **18**  | **18**  |  |

---

***Breztri***

---

| | | | | |
|:---|:---|:---|:---|:---|
| **H1 2025** | **Total** | **% Change** | **% Change** | ● Fastest growing medicine within the expanding FDC triple class <br>|
| **$m** | **Revenue** | **Actual** | **CER** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ICS/LABA/LAMA), treating COPD |
| US | 295  | 31  | 31  | ● Consistent share growth within expanding FDC triple class <br>|
| Emerging Markets | 156  | 19  | 21  | ● Growth from market share leadership in China with strong FDC triple class penetration. Unfavourable inventory movement in the second quarter<br>|
| Europe | 87  | 34  | 34  | ● Sustained growth from market share gain and new launches<br>|
| Established RoW | 45  | 34  | 36  | ● Increasing market share in Japan<br>|
| **Total** | **583**  | **28**  | **29**  |  |

---

***Tezspire***

Combined sales of *Tezspire*, recorded by Amgen and AstraZeneca, amounted to $826m in H1 2025 (H1 2024: $507m).

---

| | | | | |
|:---|:---|:---|:---|:---|
| **H1 2025** | **Total** | **% Change** | **% Change** | ● Sustained demand growth in severe asthma with launch <br>|
| **$m** | **Revenue** | **Actual** | **CER** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;momentum across multiple markets |
| US | 285  | 58  | 58  | ● Continued strong demand growth with majority of patients new to biologics <br>|
| Emerging Markets | 16  | >3x  | >3x  | ● Strong continued launch uptake<br>|
| Europe | 128  | >2x  | >2x  | ● Maintained new-to-brand leadership across multiple markets and new launches<br>|
| Established RoW | 54  | 61  | 63  | ● Strong growth driven by Japan<br>|
| **Total** | **483**  | **73**  | **73**  |  |

---

**Other R&I medicines**

---

| | | | | |
|:---|:---|:---|:---|:---|
| | | **% Change** | **% Change** |  |
| **H1 2025**<br>**$m** | **Total**<br>**Revenue** | **Actual** | **CER** |  |
| *Pulmicort* | 264  | (30) | (28) | ● Generic competition in Emerging Markets (~80% of revenue) <br>|
| *Saphnelo* | 304  | 49  | 49  | ● Strong US demand growth, ongoing launches in Europe and Established RoW<br>|
| *Airsupra* | 70  | >3x  | >3x  | ● Strong US launch momentum and volume uptake<br>|
| Other R&I | 172  | (5) | (5) |  |

---

**Biopharmaceuticals - V&I**

*Beyfortus* Total Revenue reflects the sum of Product Sales from AstraZeneca's sales of manufactured *Beyfortus* product to Sanofi and Alliance Revenue from AstraZeneca's share of gross profits and royalties on sales of *Beyfortus* in major markets outside the US.

---

| | | | | |
|:---|:---|:---|:---|:---|
| | | **% Change** | **% Change** |  |
| **H1 2025**<br>**$m** | **Total**<br>**Revenue** | **Actual** | **CER** |  |
| *Beyfortus* | 238  | >2x  | >2x  | ● Increased capacity and strong demand<br>|
| *Synagis* | 162  | (36) | (33) | ● Competition from *Beyfortus*<br>|
| *FluMist* | 10  | 20  | 16  |  |
| Other V&I | 1  | (91) | (91) |  |

---

![Graphic](azn-20250630x6k001.jpg)

**Rare Disease**

***Ultomiris***

*Ultomiris* Total Revenue includes sales of *Voydeya*, which is approved as an add on treatment to *Ultomiris* and *Soliris* for the ~20-30% of PNH patients who experience clinically significant EVH.

---

| | | | | |
|:---|:---|:---|:---|:---|
| **H1 2025** | **Total** | **% Change** | **% Change** | ● Growth due to patient demand, both naïve to branded medicines and <br>|
| **$m** | **Revenue** | **Actual** | **CER** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;conversion from Soliris in all indications (gMG, NMOSD, aHUS and PNH) |
| US | 1272  | 23  | 23  | ● Demand growth across indications, including within the competitive gMG and PNH landscapes, minimal impact from Medicare Part D redesign<br>|
| Emerging Markets | 113  | 71  | 82  | ● Expansion into new markets and growth in patient demand<br>|
| Europe | 498  | 21  | 21  | ● Strong demand growth following recent launches; competition in gMG<br>|
| Established RoW | 345  | 17  | 17  | ● Continued conversion and strong demand following new launches<br>|
| **Total** | **2228**  | **23**  | **24**  |  |

---

![Graphic](azn-20250630x6k001.jpg)

***Soliris***

---

| | | | | |
|:---|:---|:---|:---|:---|
| **H1 2025** | **Total** | **% Change** | **% Change** | ● Decline driven by conversion of patients to Ultomiris in all indications (gMG, <br>|
| **$m** | **Revenue** | **Actual** | **CER** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;NMOSD, aHUS, PNH), competition, and biosimilar pressure in Europe |
| US | 568  | (30) | (30) | ● Competition in gMG and PNH<br>|
| Emerging Markets | 224  | (12) | (1) | ● Benefitted from favourable order timing in tender markets<br>|
| Europe | 112  | (57) | (57) | ● Biosimilar competition in PNH and aHUS <br>|
| Established RoW | 70  | (40) | (38) | ● Driven by conversion to *Ultomiris* <br>|
| **Total** | **974**  | **(32)** | **(30)** |  |

---

***Strensiq***

---

| | | | | |
|:---|:---|:---|:---|:---|
| **H1 2025** | **Total** | **% Change** | **% Change** | ● Growth driven by continued patient demand and geographic expansion<br>|
| **$m** | **Revenue** | **Actual** | **CER** |  |
| US | 584  | 10  | 10  | ● Demand growth, offset by Medicare Part D redesign<br>|
| Emerging Markets | 50  | 61  | 67  |  |
| Europe | 57  | 19  | 20  |  |
| Established RoW | 55  | 24  | 23  |  |
| **Total** | **746**  | **14**  | **15**  |  |

---

**Other Rare Disease medicines**

---

| | | | | |
|:---|:---|:---|:---|:---|
| | | **% Change** | **% Change** |  |
| **H1 2025**<br>**$m** | **Total**<br>**Revenue** | **Actual** | **CER** |  |
| *Koselugo* | 275 | 11 | 13 | ● Growth driven by continued patient demand and geographic expansion<br>|
| Other Rare Disease  | 113 | 12 | 14 | ● Other Rare Disease medicines include Kanuma and Beyonttra (JP only)<br>|

---

**Other Medicines**

---

| | | | | |
|:---|:---|:---|:---|:---|
| | | **% Change** | **% Change** |  |
| **H1 2025**<br>**$m** | **Total**<br>**Revenue** | **Actual** | **CER** |  |
| *Nexium* | 434 | (8) | (5) | ● Growth in Emerging Markets, generic erosion elsewhere<br>|
| Others | 88 | (15) | (15) | ● Generic erosion<br>|

---

![Graphic](azn-20250630x6k001.jpg)

**R&D progress**

This section covers R&D events and milestones that occurred between 29 April 2025 and 28 July 2025. A comprehensive view of AstraZeneca's pipeline of medicines in human trials can be found in the latest Clinical Trials Appendix, available on AstraZeneca's investor relations webpage. The Clinical Trials Appendix includes tables with details of the ongoing clinical trials for AstraZeneca medicines and new molecular entities in the pipeline.

**Oncology**

AstraZeneca presented new data across its diverse portfolio of cancer medicines at two major medical congresses since the prior results announcement: the American Society of Clinical Oncology Annual Meeting 2025 and the European Hematology Association Congress 2025. Across the two meetings, more than 100 abstracts were presented featuring 23 approved and potential new medicines including 25 oral presentations.

*Calquence*

---

| | | |
|:---|:---|:---|
| **Approval**<br>EU | **ECHO**<br>May 2025 | <br>● In combination with bendamustine and rituximab for the treatment of previously untreated mantle cell lymphoma who are not eligible for autologous stem cell transplant.<br>|
| **Approval**<br>EU | **ACE-LY-004**<br>May 2025<br>*New disclosure* | <br>● For the treatment of relapsed or refractory mantle cell lymphoma not previously treated with a BTK inhibitor.<br>|
| **Approval**<br>EU | **AMPLIFY**<br>June 2025 | <br>● Fixed-duration regimen of Calquence in combination with venetoclax, with or without obinutuzumab, for the treatment of previously untreated chronic lymphocytic leukaemia.<br>|

---

*Datroway*

---

| | | |
|:---|:---|:---|
| **Approval**<br>US | **TROPION-Lung05,Tropion-Lung01**<br>June 2025 | <br>● For the treatment of locally advanced or metastatic EGFRm NSCLC who have received prior EGFR-directed therapy and platinum-based chemotherapy.<br>|

---

*Enhertu*

---

| | | |
|:---|:---|:---|
| **Phase III readout**<br>| **DESTINY-Breast11**<br>May 2025 | <br>● Positive high-level results demonstrated that Enhertu followed by paclitaxel, trastuzumab and pertuzumab (THP) demonstrated a statistically significant and clinically meaningful improvement in pCR rate versus standard-of-care (dose-dense doxorubicin and cyclophosphamide followed by THP) when used in the neoadjuvant setting in patients with high-risk, locally advanced HER2-positive early-stage breast cancer.<br>|
| **Data presentation** <br>ASCO | **DESTINY-Breast09**<br>June 2025 | <br>● Positive results from the DESTINY-Breast09 Phase III trial in 1st-line HER2-positive metastatic breast cancer showed Enhertu plus pertuzumab reduced the risk of disease progression or death by 44% versus THP (HR 0.56; 95% CI 0.44-0.71; p<0.00001). Median PFS was 40.7 months with Enhertu plus pertuzumab compared to 26.9 months for THP, as assessed by blinded independent central review.<br>|

---

![Graphic](azn-20250630x6k001.jpg)

*Imfinzi*

---

| | | |
|:---|:---|:---|
| **Phase III readout** | **POTOMAC**<br>May 2025 | <br>● Positive high-level results from the POTOMAC Phase III trial showed one year of treatment with Imfinzi plus standard-of-care BCG induction and maintenance therapy demonstrated a statistically significant and clinically meaningful improvement in disease-free survival for patients with high-risk non-muscle-invasive bladder cancer compared to BCG induction and maintenance therapy alone.<br>|
| **Approval**<br>China | **ADRIATIC**<br>May 2025<br>*New disclosure* | <br>● For the treatment of limited-stage small cell lung cancer whose disease has not progressed following platinum-based chemoradiation therapy.<br>|

---

---

| | | |
|:---|:---|:---|
| **Data presentation**<br>ASCO | **MATTERHORN**<br>June 2025 | <br>● Positive results from the MATTERHORN Phase III trial in resectable early-stage gastric and gastroesophageal junction cancers showed perioperative treatment with Imfinzi in combination with standard-of-care FLOT (fluorouracil, leucovorin, oxaliplatin, and docetaxel) chemotherapy demonstrated a 29% reduction in the risk of disease progression, recurrence or death versus chemotherapy alone (EFS HR 0.71; 95% CI 0.58-0.86; p<0.001) versus chemotherapy alone. Estimated median EFS was not yet reached for the Imfinzi arm versus 32.8 months for the comparator arm.<br>|
| **Approval**<br>Europe | **NIAGARA**<br>July 2025 | <br>● For the treatment of resectable muscle-invasive bladder cancer in combination with gemcitabine and cisplatin as neoadjuvant treatment, followed by Imfinzi as monotherapy adjuvant treatment after radical cystectomy (surgery to remove the bladder).<br>|
| **Priority Review**<br>US | **MATTERHORN**<br>July 2025 | <br>● For the treatment of resectable, early-stage and locally advanced (Stages II, III, IVA) gastric and gastroesophageal junction cancers.<br>|

---

*Tagrisso*

---

| | | |
|:---|:---|:---|
| **Approval**<br>Japan<br>| **LAURA**<br>May 2025<br>*New disclosure* | <br>● As maintenance therapy after definitive chemoradiation therapy in locally advanced and unresectable *EGFR*m NSCLC.<br>|
| **Phase III readout** | **FLAURA2**<br>July 2025 | <br>● Positive high-level results from the final OS analysis of the FLAURA2 Phase III trial showed *Tagrisso* with the addition of pemetrexed and platinum-based chemotherapy demonstrated a statistically significant and clinically meaningful improvement in the key secondary endpoint of OS compared to *Tagrisso* monotherapy for patients with 1st-line locally advanced or metastatic *EGFR*m NSCLC.<br>|

---

![Graphic](azn-20250630x6k001.jpg)

*Orpathys*

---

| | | |
|:---|:---|:---|
| **Approval**<br>China | **SACHI**<br>June 2025<br>*New disclosure* | <br>● In combination with *Tagrisso* for the treatment of patients with locally advanced or metastatic non-squamous *EGFR*m NSCLC with MET amplification who have progressed following EGFR tyrosine kinase inhibitor therapy.<br>|

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camizestrant

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| | | |
|:---|:---|:---|
| **Data presentation**<br>ASCO | **SERENA-6**<br>June 2025 | <br>● Positive results from the SERENA-6 Phase III trial showed that camizestrant in combination with a CDK4/6 inhibitor (palbociclib, ribociclib or abemaciclib) reduced the risk of disease progression or death by 56% compared to standard-of-care treatment (HR 0.44; 95% CI 0.31-0.60; p<0.00001) as assessed by investigator compared to continuing standard-of-care treatment with an aromatase inhibitor in combination with a CDK4/6 inhibitor in the 1st-line treatment of patients with HR-positive, HER2-negative advanced breast cancer whose tumours have an emergent *ESR1* mutation. Median PFS was 16.0 months for patients who switched to the camizestrant combination versus 9.2 months for the comparator arm. <br>|

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**BioPharmaceuticals – CVRM**

baxdrostat

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| | | |
|:---|:---|:---|
| **Phase III readout** | **BaxHTN**<br>July 2025 | <br>● Positive high-level results from the BaxHTN Phase III trial in uncontrolled or treatment resistant hypertension showed that two doses (2mg and 1mg) demonstrated a statistically significant and clinically meaningful reduction in mean seated systolic blood pressure compared with placebo at 12 weeks. The trial also successfully met all secondary endpoints. Patients received baxdrostat or placebo on top of standard-of-care.<br>|

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**BioPharmaceuticals – R&I**

*Breztri*

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| | | |
|:---|:---|:---|
| **Phase III readout** | **KALOS/LOGOS**<br>May 2025<br>| <br>● Positive high-level results from the Phase III KALOS and LOGOS trials in patients with uncontrolled asthma showed that *Breztri* met all primary endpoints, demonstrating a statistically significant and clinically meaningful improvement in lung function compared with inhaled ICS/LABA medicines.<br>|
| **CHMP opinion**<br>**EU** | **NGP programme**<br>July 2025 | <br>● *Trixeo* (*Breztri*), already licensed for the treatment of chronic obstructive pulmonary disease (COPD) in adults, has received a positive opinion from the CHMP endorsing it for use with an innovative, next-generation propellant with near-zero global warming potential. Based on the CHMP positive opinion, AstraZeneca will now begin to transition its *Trixeo* supply to the next-generation propellant in Europe<br>|

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![Graphic](azn-20250630x6k001.jpg)

*Fasenra*

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| | | |
|:---|:---|:---|
| **Phase III readout**<br>| **NATRON**<br>June 2025<br>*New disclosure* | <br>● Positive high-level results from the NATRON Phase III trial showed treatment with *Fasenra*, dosed monthly in a single injection, demonstrated a statistically significant and clinically meaningful improvement in the primary endpoint of time to first worsening or flare versus placebo in patients with hypereosinophilic syndrome. The safety and tolerability profile for *Fasenra* in this trial was consistent with the known profile of the medicine. The data will be presented at a forthcoming medical meeting and shared with regulatory authorities.<br>|

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*Saphnelo*

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| | | |
|:---|:---|:---|
| **Phase III readout**<br>| **AZALEA**<br>July 2025<br>*New disclosure* | <br>● Positive high-level results demonstrated that *Saphnelo* resulted in statistically significant and clinically meaningful improvement in the primary endpoint, BICLA Response at week 52, compared to placebo, in Asian patients with moderate to severe SLE despite standard-of-care. Improvements across secondary endpoints were also observed. The safety profile was generally consistent with the established safety profile. The data will be presented at a forthcoming medical meeting and shared with regulatory authorities.<br>|

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*Airsupra*

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| | | |
|:---|:---|:---|
| **Data presentation**<br>ATS 2025 | **BATURA**<br>May 2025<br>| <br>● Positive full results from the BATURA Phase IIIb trial of *Airsupra* demonstrated a 47% reduction (5.1%, 9.1%, hazard ratio 0.53; 95% CI, 0.39-0.73; p<0.001) in the risk of severe exacerbations in mild asthma compared with albuterol alone. In a key secondary endpoint, adults and adolescents ages 12 and older receiving *Airsupra* had 63% lower exposure to total systemic corticosteroids (SCS) (p<0.001) over the treatment period compared with albuterol-alone. Similar reductions in all primary and secondary endpoints were seen in a prespecified subgroup of adult patients (≥18 years) on treatment.<br>|

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**BioPharmaceuticals – V&I**

IVX-A12

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| | | |
|:---|:---|:---|
| **Programme update**<br>| **NCT06481579**<br>April 2025 | <br>● The Phase II trial to characterise safety and immunogenicity in adults 60 years of age and older has completed, and IVX-A12 was shown to be well-tolerated and immunogenic. AstraZeneca has identified opportunities to further enhance the vaccine, and is now progressing the improved RSV/hMPV combination.<br>|

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**Rare Disease**

Alexion, AstraZeneca Rare Disease, presented new data at the European Hematology Association Congress 2025, since prior earnings. Nine abstracts were presented in rare haematology, in both PNH and HSCT-TMA.

gefurulimab

![Graphic](azn-20250630x6k001.jpg)

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| | | |
|:---|:---|:---|
| **Phase III readout**<br>| **PREVAIL**<br>July 2025 | <br>● Positive high-level results from a global, randomised, double-blind, placebo-controlled Phase III trial in adults with anti-acetylcholine receptor (AChR) antibody-positive (Ab+) generalised myasthenia gravis (gMG) showed that gefurulimab met its primary and all secondary endpoints. Data demonstrated a statistically significant and clinically meaningful improvement from baseline in Myasthenia Gravis Activities of Daily Living (MG-ADL) total score at week 26 compared to placebo.<br>|

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anselamimab

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| | | |
|:---|:---|:---|
| **Phase III readout**<br>| **CARES Programme**<br>July 2025<br>| <br>● High-level results from the CARES (301/2) Phase III clinical programme showed that anselamimab did not achieve statistical significance for the primary endpoint compared to placebo in patients with Mayo stages IIIa and IIIb light chain amyloidosis. The primary endpoint was defined as a hierarchical combination of time to all-cause mortality (ACM) and frequency of cardiovascular hospitalisations (CVH). Anselamimab showed highly clinically meaningful improvement in time to ACM and frequency of CVH in a prespecified subgroup of patients, compared to placebo. <br>|

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*Ultomiris*

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| | | |
|:---|:---|:---|
| **Data presentation**<br>EHA | **ALXN1210-TMA-314**<br>June 2025 | <br>● Initial results from the ALXN1210-TMA-314 Phase III, single arm trial evaluating *Ultomiris* in paediatric patients with HSCT-TMA. *Ultomiris* demonstrated clinically meaningful improvements in the individual components of TMA response (platelets, LDH and urinary protein/creatinine ratio) at 26 weeks, and a clinically meaningful improvement in the secondary endpoint of overall survival at six months. 58.5% (95% CI: 42.1-73.7) and 53.7% (95% CI: 37.4-69.3) of participants met the predefined response criteria for platelet and urine protein/creatinine ratio, respectively, and 36.6% (95% CI: 22.1-53.1) of participants normalised LDH from baseline during the 26-week treatment period. Overall survival was 92.6% (95% CI: 78.8-97.6) at day 100 and 87.2% (95% CI: 71.8-94.5) at week 26.<br>|

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![Graphic](azn-20250630x6k001.jpg)

**Sustainability**

Sustainability highlights

AstraZeneca introduced an updated Sustainability strategy which focuses on the Company's sustainability impact and how it does business. This strategy evolution recognises the connection between business growth and the need to address the major health challenges of our time, and aims to support the health of people, society and the planet.

The Company will continue to drive sustainable impact through action on climate and nature, health equity and health systems resilience, leveraging the latest science and innovation. It will also focus on creating long-term value, resilience and trust by operating responsibly and ethically, maintaining robust governance, investing in its people and following its Values

– In May 2025, the Company published its second Sustainability Impact publication which introduces the updated strategy and shares examples of impact from across the business. It also presented 2024 Sustainability Highlights to investors and analysts

– AstraZeneca was named in the top 20 of TIME's Most Sustainable Companies, its highest ranking to date in the list of 500 businesses. AstraZeneca and Alexion were also included in Newsweek's World's Greenest Companies 2025

– AstraZeneca achieved the top ranking in IDEA Pharma's index for 2025, coming first for "Invention" and joint third for "Innovation". This annual ranking assesses companies' ability to develop and commercialise products.

– AstraZeneca has been A-rated for Supplier Engagement by CDP for 2024 and is on the Leaderboard for the third consecutive year, recognising its extensive supply chain engagement and focus on disclosing carbon emissions data and actions to CDP

– The Company also ranked fourth in the 2025 Gartner Top 25 Supply Chains, the highest ranking for a pharmaceutical company this year

– AstraZeneca SVP, Chief Digital Officer and CIO Cindy Hoots was ranked in the top 20 of this year's Top 100 Women in Technology recognising her leadership in driving a digital-first strategy

Sustainability impact

Climate and nature

Reducing the carbon impact of pressurised metered dose inhalers is a key product-related element of AstraZeneca's Ambition Zero Carbon strategy. With an innovative next-generation propellant with 99.9% lower Global Warming Potential than current propellants, Breztri/Trixeo Aerosphere has received positive CHMP opinion and AstraZeneca will now begin to transition its Trixeo supply to the next-generation propellant in Europe<br>

At London Climate Action Week, AstraZeneca joined His Majesty King Charles III, ministers from the UK and Brazil, and global leaders for an event on 'Nature Action: Mobilising Frameworks and Finance' and was also represented at several panel and roundtable discussions. The Company celebrated the use of 100% renewable energy for both heat and power at its Macclesfield site<br>

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| | |
|:---|:---|
| – | The company participated in engagements with French, Italian and UK stakeholders, including a Circular Bioeconomy Alliance event in Rome in the presence of His Majesty King Charles III, as well as an event hosted by the French government on health systems decarbonisation. AstraZeneca showcased its pioneering work in quantifying the environmental impact of patient care, including its new Care pathways Environmental Sustainability Assessment tool (CARESA) |

---

EVP International, Iskra Reic met with China's Vice President Han Zheng to discuss the green transition as part of the Sustainable Markets Initiative (SMI) China Forum in Beijing. She underscored AstraZeneca's commitment to Healthy China 2030 and Common Health, as well as the Company's collaborative efforts to decarbonise the health sector in Chinese media interviews<br>

Health equity

AstraZeneca's Qure.ai partnership reached a significant milestone, achieving five million chest X-rays assessed by AI for lung cancer in more than 20 countries. This partnership has resulted in nearly 50,000 referrals for follow-up testing to date and demonstrates the transformative potential of technology and advanced data analytics for early lung cancer detection<br>

– At the World Health Assembly (WHA) in Geneva, Switzerland, AstraZeneca organised the first cancer planners' summit with the Union for International Cancer Control, attended by more than 100 delegates from over 50 countries,

![Graphic](azn-20250630x6k001.jpg)

and also hosted events on lung health, kidney disease and rare diseases. The Company engaged with leaders from countries including the US, Brazil, the UAE, Egypt, Malaysia and Spain as well as NGOs on topics spanning health equity, resilience and climate action

– Through the Company's flagship health equity initiative, Healthy Heart Africa, the Company engaged at Africa Health ExCon 2025, where a national strategy for managing chronic kidney disease in Egypt was launched with government representatives

Health systems resilience

– The Partnership for Health System Sustainability and Resilience (PHSSR) which the Company co-founded in 2020, added to its growing body of evidence, launching its EU Expert Advisory Group's report on sustainable healthcare financing in Europe

AstraZeneca convened the PHSSR Summit 2025 at EXPO in Osaka, Japan with AstraZeneca Chair Michel Demaré, Japanese government and health systems stakeholders. The Summit focused on action on non-communicable diseases (NCDs) and healthcare digitisation. Additional high-level engagements at EXPO 2025 this quarter included an event on transforming the delivery of healthcare with a focus on COPD, attended by EVP BioPharmaceuticals Business, Ruud Dobber, and engagements on rare disease led by Marc Dunoyer, CEO Alexion<br>

– At Abu Dhabi Global Health Week, a Company delegation led by Chair Michel Demaré and EVP International, Iskra Reic, focused on sustainable health system investment and health equity

**Operating and financial review**

Reporting currency

All narrative on growth and results in this section is based on actual exchange rates, and financial figures are in US$ millions ($m), unless stated otherwise.

Reporting period

The performance shown in this announcement covers the six-month period to 30 June 2025 ('H1 2025') compared to the six-month period to 30 June 2024 ('H1 2024'), and the three-month period to 30 June 2025 ('the quarter' or 'Q2 2025') compared to the three-month period to 30 June 2024 ('Q2 2024'), unless stated otherwise.

Core financial measures

Core financial measures, EBITDA, Net debt, Gross Margin, Operating Margin and CER are non-GAAP financial measures because they cannot be derived directly from the Group's Condensed consolidated interim financial statements.

Management believes that these non-GAAP financial measures, when provided in combination with Reported results, provide investors and analysts with helpful supplementary information to understand better the financial performance and position of the Group on a comparable basis from period to period.

These non-GAAP financial measures are not a substitute for, or superior to, financial measures prepared in accordance with GAAP.

Core financial measures are adjusted to exclude certain significant items:

– Charges and provisions related to our global restructuring programmes, which includes charges that relate to the impact of restructuring programmes on our capitalised manufacturing assets and IT assets

– Amortisation and impairment of intangible assets, including impairment reversals but excluding any charges relating to IT assets

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| | |
|:---|:---|
| – | Other specified items, principally comprising acquisition-related costs and credits, which include the imputed finance charges and fair value movements relating to contingent consideration on business combinations, imputed finance charges and remeasurement adjustments on certain Other payables arising from intangible asset acquisitions, remeasurement adjustments relating to certain Other payables and debt items assumed from the Alexion acquisition and legal settlements |

---

– The tax effects of the adjustments above are excluded from the Core Tax charge

![Graphic](azn-20250630x6k001.jpg)

Details on the nature of Core financial measures are provided on page 70 of the Annual Report and Form 20-F Information 2024.

Reference should be made to the Reconciliation of Reported to Core financial measures table included in the Financial Performance section in this announcement.

Definitions

Gross Margin is defined as Gross Profit as a percentage of Total Revenue.

EBITDA is defined as Reported Profit before tax after adding back Net finance expense, results from Joint ventures and associates and charges for Depreciation, amortisation and impairment. Reference should be made to the Reconciliation of Reported Profit before tax to EBITDA included in the Financial Performance section in this announcement.

Operating margin is defined as Operating profit as a percentage of Total Revenue.

Net debt is defined as Interest-bearing loans and borrowings and Lease liabilities, net of Cash and cash equivalents, Other investments, and Net derivative financial instruments. Reference should be made to Note 3 'Net debt', included in the Notes to the interim financial statements in this announcement.

The Company strongly encourages investors and analysts not to rely on any single financial measure, but to review AstraZeneca's financial statements, including the Notes thereto, and other available Company reports, carefully and in their entirety.

Due to rounding, the sum of a number of dollar values and percentages in this announcement may not agree to totals.

![Graphic](azn-20250630x6k001.jpg)

**Financial performance**

**Table 7: Reported Profit and Loss**

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| | | | | | | | | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
|  |  | |  | |  | **% Change** | **% Change** | **% Change** |  | |  | |  | **% Change** | **% Change** | **% Change** |
|  |  | **H1 2025**<br>**$m** |  | **H1 2024**<br>**$m** |  | **Actual** |  | **CER** |  | **Q2 2025**<br>**$m** |  | **Q2 2024**<br>**$m** |  | **Actual** |  | **CER** |
| *- Product Sales* |  | *26670* |  | *24629* |  | *8* |  | *10* |  | *13795* |  | *12452* |  | *11* |  | *10* |
| *- Alliance Revenue* |  | *1293* |  | *939* |  | *38* |  | *38* |  | *654* |  | *482* |  | *36* |  | *35* |
| Product Revenue |  | 27963 |  | 25568 |  | 9 |  | 11 |  | 14449 |  | 12934 |  | 12 |  | 11 |
| Collaboration Revenue |  | 82 |  | 49 |  | 68 |  | 66 |  | 8 |  | 4 |  | >2x |  | >2x |
| **Total Revenue** |  | **28045** |  | **25617** |  | **9** |  | **11** |  | **14457** |  | **12938** |  | **12** |  | **11** |
| Cost of sales |  | (4714) |  | (4401) |  | 7 |  | 10 |  | (2473) |  | (2183) |  | 13 |  | 9 |
| **Gross profit** |  | **23331** |  | **21216** |  | **10** |  | **11** |  | **11984** |  | **10755** |  | **11** |  | **12** |
| Distribution expense |  | (278) |  | (267) |  | 4 |  | 6 |  | (143) |  | (132) |  | 8 |  | 8 |
| R&D expense |  | (6707) |  | (5791) |  | 16 |  | 16 |  | (3548) |  | (3008) |  | 18 |  | 16 |
| SG&A expense |  | (9356) |  | (9424) |  | (1) |  |  |  | (4864) |  | (4929) |  | (1) |  | (2) |
| Other operating income & expense |  | 192 |  | 127 |  | 52 |  | 53 |  | 79 |  | 60 |  | 30 |  | 33 |
| **Operating profit** |  | **7182** |  | **5861** |  | **23** |  | **24** |  | **3508** |  | **2746** |  | **28** |  | **32** |
| Net finance expense |  | (636) |  | (645) |  | (1) |  |  |  | (371) |  | (343) |  | 8 |  | 10 |
| Joint ventures and associates |  | (17) |  | (19) |  | (7) |  | (9) |  | (10) |  | (6) |  | >2x |  | 91 |
| **Profit before tax** |  | **6529** |  | **5197** |  | **26** |  | **27** |  | **3127** |  | **2397** |  | **30** |  | **34** |
| Taxation |  | (1160) |  | (1089) |  | 7 |  | 7 |  | (679) |  | (469) |  | 45 |  | 49 |
| *Tax rate* |  | *18%*  |  | *21%*  |  |  |  |  |  | *22%*  |  | *20%*  |  |  |  |  |
| **Profit after tax** |  | **5369** |  | **4108** |  | **31** |  | **32** |  | **2448** |  | **1928** |  | **27** |  | **31** |
| **Earnings per share** |  | $**3.46** |  | $**2.65** |  | **31** |  | **32** |  | $**1.58** |  | $**1.24** |  | **27** |  | **31** |

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**Table 8: Reconciliation of Reported Profit before tax to EBITDA**

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
|  | | | **% Change** | **% Change** | | | **% Change** | **% Change** |
|  | **H1 2025**<br>**$m** | **H1 2024**<br>**$m** | **Actual** | **CER** | **Q2 2025**<br>**$m** | **Q2 2024**<br>**$m** | **Actual** | **CER** |
| **Reported Profit before tax** | **6529** | **5197** | **26** | **27** | **3127** | **2397** | **30** | **34** |
| Net finance expense | 636 | 645 | (1) |  | 371 | 343 | 8 | 10 |
| Joint ventures and associates | 17 | 19 | (7) | (9) | 10 | 6 | >2x | 91 |
| Depreciation, amortisation and impairment | 2673 | 2534 | 5 | 5 | 1389 | 1279 | 9 | 7 |
| **EBITDA** | **9855** | **8395** | **17** | **18** | **4897** | **4025** | **22** | **24** |

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**Table 9: Reconciliation of Reported to Core financial measures: H1 2025**

---

| | | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| |  | | | | | |  | **% Change** | **% Change** | **% Change** |
| <br>For the **half year** ended 30 June |  | <br>**Reported**<br>**$m** | <br>**Restructuring**<br>**$m** | **Intangible Asset** <br>**Amortisation &** <br>**Impairments**<br>**$m** | <br>**Other**<br>**$m** | <br>**Core**<br>**$m** |  | **Actual** |  | **CER** |
| **Gross profit** |  | **23331** | **(70)** | **17** | **1** | **23279** |  | **9** |  | **10** |
|  *- Gross Margin* |  | *83%*  |  |  |  | *83%*  |  | *—* |  | *—* |
| Distribution expense |  | (278) |  |  |  | (278) |  | 4 |  | 6 |
| R&D expense |  | (6707) | 101 | 62 | 3 | (6541) |  | 17 |  | 17 |
|  *- R&D % of Total Revenue* |  | *24%*  |  |  |  | *23%*  |  | *-2pp* |  | *-1pp* |
| SG&A expense |  | (9356) | 76 | 1943 | 78 | (7259) |  | 2 |  | 3 |
|  *- SG&A % of Total Revenue* |  | *33%*  |  |  |  | *26%*  |  | *+2pp* |  | *+2pp* |
| Total operating expense |  | (16341) | 177 | 2005 | 81 | (14078) |  | 8 |  | 9 |
| Other operating income & expense |  | 192 | (6) |  |  | 186 |  | 50 |  | 51 |
| **Operating profit** |  | **7182** | **101** | **2022** | **82** | **9387** |  | **12** |  | **13** |
|  *- Operating Margin* |  | *26%*  |  |  |  | *33%*  |  | *+1pp* |  | *+1pp* |
| Net finance expense |  | (636) |  |  | 118 | (518) |  | (3) |  | (1) |
| Taxation |  | (1160) | (30) | (386) | (49) | (1625) |  | 1 |  | 2 |
| **EPS** |  | $**3.46** | $**0.05** | $**1.06** | $**0.09** | $**4.66** |  | **16** |  | **17** |

---

![Graphic](azn-20250630x6k001.jpg)

**Table 10: Reconciliation of Reported to Core financial measures: Q2 2025**

---

| | | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| |  | | | |  | | | **% Change** | **% Change** | **% Change** |
| <br>**For the quarter ended 30 June** |  | <br>**Reported**<br>**$m** | <br>**Restructuring**<br>**$m** | **Intangible Asset** <br>**Amortisation &** <br>**Impairments**<br>**$m** |  | <br>**Other**<br>**$m** | <br>**Core**<br>**$m** | **Actual** |  | **CER** |
| **Gross profit** |  | **11984** | **(78)** | **9** |  | **(1)** | **11914** | **11** |  | **11** |
| *- Gross Margin* |  | *83%*  |  |  |  |  | *82%*  | *-1pp* |  | *—* |
| Distribution expense |  | (143) | (3) |  |  |  | (146) | 10 |  | 10 |
| R&D expense |  | (3548) | 41 | 52 |  | 2 | (3453) | 20 |  | 18 |
| *- R&D % of Total Revenue* |  | *25%*  |  |  |  |  | *24%*  | -2pp |  | *-1pp* |
| SG&A expense |  | (4864) | 26 | 986 |  | 50 | (3802) | 2 |  | 1 |
| *- SG&A % of Total Revenue* |  | *34%*  |  |  |  |  | *26%*  | *+3pp* |  | *+3pp* |
| Total operating expense |  | (8555) | 64 | 1038 |  | 52 | (7401) | 10 |  | 9 |
| Other operating income & expense |  | 79 | (7) |  |  | (1) | 71 | 19 |  | 23 |
| **Operating profit** |  | **3508** | **(21)** | **1047** |  | **50** | **4584** | **12** |  | **14** |
| *- Operating Margin* |  | *24%*  |  |  |  |  | *32%*  |  |  | *1pp* |
| Net finance expense |  | (371) |  |  |  | 68 | (303) | 6 |  | 9 |
| Taxation |  | (679) | (2) | (199) |  | (31) | (911) | 23 |  | 26 |
| **EPS** |  | $**1.58** | $**(0.01)** | $**0.55** |  | $**0.05** | $**2.17** | **10** |  | **12** |

---

**Profit and Loss drivers**

**Gross profit**

The stable Gross Margin (Reported and Core) in H1 2025 was a result of:

– Positive effects from geographic mix

---

| | |
|:---|:---|
| – | Negative effects from product mix. The rising contribution of Product Sales with profit sharing arrangements (*Lynparza*, *Enhertu*, *Tezspire*, *Koselugo*) has a negative impact on Gross Margin because AstraZeneca records Product Sales in certain markets and pays away a share of the gross profits to its collaboration partners. The profit share paid to partners is recorded in AstraZeneca's Cost of sales line |

---

– Pricing adjustments, for example to sales reimbursed by the Medicare Part D programme in the US, diluted the Gross Margin.

Variations in Gross Margin performance between periods can continue to be expected due to product seasonality, foreign exchange fluctuations, and other effects.

**R&D expense**

The change in R&D expense (Reported and Core) in the period was impacted by:

– Positive data read-outs for high-value pipeline opportunities that have ungated late-stage trials

– Investment in platforms, new technology and capabilities to enhance R&D capabilities

– Addition of R&D projects following completion of previously announced business development activity

**SG&A expense**

– The change in SG&A expense (Reported and Core) in the period was driven primarily by market development activities for launches and to support continued growth in existing brands

Other operating income and expense

– Other operating income in H1 2025 consisted primarily of royalties and an upfront fee on a divestment

**Net finance expense**

Core Net finance expense decreased 3% (1% at CER) in H1 2025, mainly driven by an adjustment of interest on tax, due to a reduction of tax liabilities relating to prior periods, recognised in the first quarter.

Core Net finance expense increased 6% (9% at CER) in Q2 2025, mainly driven by a reduction in short-term deposits.

![Graphic](azn-20250630x6k001.jpg)

**Taxation**

The effective Reported and Core tax rates for the six months to 30 June 2025 were 18% (H1 2024: 21% and 20% respectively).

These tax rates benefited from a reduction of tax liabilities arising from updates to estimates of prior period tax liabilities following settlements with tax authorities in Q1 2025.

The cash tax paid for the six months ended 30 June 2025 was $1,549m (H1 2024: $1,337m), representing 24% of Reported Profit before tax (H1 2024: 26%).

**Dividend**

The interim dividend declared with H1 2025 results increased by 3% to $1.03.

**Cash Flow**

**Table 11: Cash Flow summary: H1 2025**

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| | | | |
|:---|:---|:---|:---|
|  | **2025** | **2024** | **Change** |
| For the **half year** ended 30 June | **$m** | **$m** | **$m** |
| Reported Operating profit | 7182 | 5861 | 1321 |
| Depreciation, amortisation and impairment | 2673 | 2534 | 139 |
| Movement in working capital and short-term provisions | (771) | (584) | (187) |
| Gains on disposal of intangible assets | (87) | (21) | (66) |
| Fair value movements on contingent consideration arising from business combinations | (30) | 251 | (281) |
| Non-cash and other movements | 304 | (550) | 854 |
| Interest paid | (623) | (583) | (40) |
| Taxation paid | (1549) | (1337) | (212) |
| **Net cash inflow from operating activities** | **7099** | **5571** | **1528** |
| **Net cash inflow before financing activities** | **3738** | **286** | **3452** |
| **Net cash (outflow)/inflow from financing activities**  | **(2189)** | **806** | **(2995)** |

---

**Net cash flow**

The change in Net cash inflow from operating activities of $1,528m is primarily driven by the increased operating profit in 2025.

The change in Net cash inflow before financing activities of $3,452m is primarily driven by the reduction in cash outflow relating to the Acquisitions of subsidiaries, net of cash acquired of $2,771m, which in 2024 related to the acquisition of Gracell Biotechnologies Inc. and the acquisition of Fusion Pharmaceuticals Inc.

The change in Net cash (outflow)/inflow from financing activities of $2,995m is primarily driven by the issue of new long-term loans of $4,976m in 2024, with no issuance in 2025, and offset by the repayment of loans of $2,643m in 2024, with no repayment in 2025.

**Capital expenditure**

Capital expenditure on tangible assets and Software-related intangible assets amounted to $1,303m in H1 2025 (H1 2024: $903m). The increase of capital expenditure in 2025 was driven by investment in several major manufacturing projects and continued investment in technology upgrades.

**Net debt**

Net debt increased by $657m in the six months to 30 June 2025 to $25,227m. Details of the committed undrawn bank facilities are disclosed within the going concern section of Note 1. Details of the Company's solicited credit ratings and further details on Net debt are disclosed in Note 3.

![Graphic](azn-20250630x6k001.jpg)

**Net debt**

**Table 12: Net debt summary**

---

| | | | |
|:---|:---|:---|:---|
|  | **At 30 Jun**<br>**2025**<br>**$m** | **At 31 Dec**<br>**2024**<br>**$m** | **At 30 Jun**<br>**2024**<br>**$m** |
| Cash and cash equivalents | 7058 | 5488 | 6916 |
| Other investments | 50 | 166 | 160 |
| **Cash and investments** | **7108** | **5654** | **7076** |
| Overdrafts and short-term borrowings | (561) | (330) | (596) |
| Commercial paper | (1470) |  | (2453) |
| Lease liabilities | (1633) | (1452) | (1241) |
| Current instalments of loans | (4461) | (2007) | (2018) |
| Non-current instalments of loans | (24714) | (26506) | (27225) |
| **Interest-bearing loans and borrowings (Gross debt)** | **(32839)** | **(30295)** | **(33533)** |
| Net derivatives | 504 | 71 | 133 |
| **Net Debt** | **(25227)** | **(24570)** | **(26324)** |

---

**Summarised financial information for guarantee of securities of subsidiaries**

AstraZeneca Finance LLC ("AstraZeneca Finance") is the issuer of 1.2% Notes due 2026, 4.8% Notes due 2027, 4.875% Notes due 2028, 1.75% Notes due 2028, 4.85% Notes due 2029, 4.9% Notes due 2030, 4.9% Notes due 2031, 2.25% Notes due 2031, 4.875% Notes due 2033 and 5% Notes due 2034 (the "AstraZeneca Finance USD Notes"). Each series of AstraZeneca Finance USD Notes has been fully and unconditionally guaranteed by AstraZeneca PLC. AstraZeneca Finance is 100% owned by AstraZeneca PLC and each of the guarantees issued by AstraZeneca PLC is full and unconditional and joint and several.

The AstraZeneca Finance USD Notes are senior unsecured obligations of AstraZeneca Finance and rank equally with all of AstraZeneca Finance's existing and future senior unsecured and unsubordinated indebtedness. The guarantee by AstraZeneca PLC of the AstraZeneca Finance USD Notes is the senior unsecured obligation of AstraZeneca PLC and ranks equally with all of AstraZeneca PLC's existing and future senior unsecured and unsubordinated indebtedness. Each guarantee by AstraZeneca PLC is effectively subordinated to any secured indebtedness of AstraZeneca PLC to the extent of the value of the assets securing such indebtedness. The AstraZeneca Finance USD Notes are structurally subordinated to indebtedness and other liabilities of the subsidiaries of AstraZeneca PLC, none of which guarantee the AstraZeneca Finance USD Notes.

AstraZeneca PLC manages substantially all of its operations through divisions, branches and/or investments in subsidiaries and affiliates. Accordingly, the ability of AstraZeneca PLC to service its debt and guarantee obligations is also dependent upon the earnings of its subsidiaries, affiliates, branches and divisions, whether by dividends, distributions, loans or otherwise. Please refer to the Consolidated financial statements of AstraZeneca PLC in our Annual Report on Form 20-F as filed with the SEC and information contained herein for further financial information regarding AstraZeneca PLC and its consolidated subsidiaries. For further details, terms and conditions of the AstraZeneca Finance USD Notes please refer to AstraZeneca PLC's reports on Form 6-K furnished to the SEC on 22 February 2024, 3 March 2023 and 28 May 2021.

Pursuant to Rule 13-01 and Rule 3-10 of Regulation S-X under the Securities Act of 1933, as amended (the "Securities Act"), we present below the summary financial information for AstraZeneca PLC, as Guarantor, excluding its consolidated subsidiaries, and AstraZeneca Finance, as the issuer, excluding its consolidated subsidiaries. The following summary financial information of AstraZeneca PLC and AstraZeneca Finance is presented on a combined basis and transactions between the combining entities have been eliminated. Financial information for non-guarantor entities has been excluded. Intercompany balances and transactions between the obligor group and the non-obligor subsidiaries are presented on separate lines.

![Graphic](azn-20250630x6k001.jpg)

**Obligor group summarised statements**

**Table 13: Obligor group summarised Statement of comprehensive income: H1 2025**

---

| | | |
|:---|:---|:---|
|  | **2025** | **2024** |
| For the **half year** ended 30 June | **$m** | **$m** |
| Total Revenue |  |  |
| Gross profit |  |  |
| Operating loss |  |  |
| Loss for the period | (666) | (545) |
| Transactions with subsidiaries that are not issuers or guarantors | 6160 | 964 |

---

**Table 14: Obligor group summarised Statement of financial position**

---

| | | |
|:---|:---|:---|
|  | **At 30 Jun**<br>**2025**<br>**$m** | **At 30 Jun**<br>**2024**<br>**$m** |
| Current assets | 43 | 13 |
| Non-current assets | 147 |  |
| Current liabilities | (6506) | (4795) |
| Non-current liabilities | (24720) | (27133) |
| Amounts due from subsidiaries that are not issuers or guarantors | 23554 | 20730 |
| Amounts due to subsidiaries that are not issuers or guarantors |  |  |

---

**Capital allocation**

The Group's capital allocation priorities include: investing in the business and pipeline; maintaining a strong, investment-grade credit rating; potential value-enhancing business development opportunities; and supporting the progressive dividend policy.

In approving the declaration of dividends, the Board considers both the liquidity of the company and the level of reserves legally available for distribution.

In FY 2025, the Company intends to increase the annual dividend per share declared to $3.20 per share. Dividends are paid to shareholders from AstraZeneca PLC, a Group holding company with no direct operations. The ability of AstraZeneca PLC to make shareholder distributions is dependent on the creation of profits for distribution and the receipt of funds from subsidiary companies.

The consolidated Group reserves set out in the Condensed consolidated statement of financial position do not reflect the profit available for distribution to the shareholders of AstraZeneca PLC.

In FY 2024, capital expenditure on tangible assets and Software-related intangible assets amounted to $2,218m. In FY 2025 the Group expects to increase expenditure on tangible assets and Software-related intangible assets by approximately 50%, driven by manufacturing expansion projects and investments in systems and technology.

**Foreign exchange**

The Company's transactional currency exposures on working capital balances, which typically extend for up to three months, are hedged where practicable using forward foreign exchange contracts against the individual companies' reporting currency. In addition, the Company's external dividend payments, paid principally in pound sterling and Swedish krona, are fully hedged from the time of their announcement to the payment date. Foreign exchange gains and losses on forward contracts transacted for transactional hedging are taken to profit or to Other comprehensive income if the contract is in a designated cashflow hedge.

![Graphic](azn-20250630x6k001.jpg)

**Table 15: Currency sensitivities**

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | |  |  |  |  |  | **Annual impact of 5%** | **Annual impact of 5%** |
| | | **Exchange rate vs USD (average rate in period)** | **Exchange rate vs USD (average rate in period)** | **Exchange rate vs USD (average rate in period)** | **Exchange rate vs USD (average rate in period)** | **Exchange rate vs USD (average rate in period)** | **weakening vs USD**<sup>1</sup> **($m)** | **weakening vs USD**<sup>1</sup> **($m)** |
| <br>**Currency** | <br>**Primary Relevance** | **FY** <br>**2024**<sup>2</sup> | **YTD** <br>**2025**<sup>3</sup> | **Change**<br>**(%)** | **June** <br>**2025**<sup>4</sup> | **Change** <br>**(%)** | **Total** <br>**Revenue** | **Core Operating**<br>**Profit** |
| EUR | Total Revenue | 0.92 | 0.91 | 1 | 0.87 | 6 | (461) | (232) |
| CNY | Total Revenue | 7.21 | 7.26 | (1) | 7.18 | 0 | (313) | (171) |
| JPY | Total Revenue | 151.46 | 148.46 | 2 | 144.50 | 5 | (179) | (121) |
| GBP | Operating expense | 0.78 | 0.77 | 2 | 0.74 | 6 | (68) | 124 |
| SEK | Operating expense | 10.57 | 10.17 | 4 | 9.56 | 11 | (9) | 69 |
| Other |  |  |  |  |  |  | (557) | (289) |

---

&nbsp;&nbsp;&nbsp;&nbsp;*1.* *Assumes the average exchange rate vs USD in FY 2025 is 5% lower than the average rate in FY 2024. The impact data are estimates, based on best prevailing assumptions around currency profiles.* 

&nbsp;&nbsp;&nbsp;&nbsp;*2.* *Based on average daily spot rates 1 January 2024 to 31 December 2024.* 

&nbsp;&nbsp;&nbsp;&nbsp;*3.* *Based on average daily spot rates 1 January 2025 to 30 June 2025.* 

&nbsp;&nbsp;&nbsp;&nbsp;*4.* *Based on average daily spot rates 1 June 2025 to 30 June 2025.* 

**Related-party transactions**

There have been no significant related-party transactions in the period.

**Principal risks and uncertainties**

The Principal Risks and uncertainties facing the Group are set out on pages 65 to 66 of the Annual Report and Form 20-F Information 2024 and summarised below. They are not expected to change in respect of the second six months of the financial year and remain appropriate for the Group. In summary, the principal risks and uncertainties listed in the Annual Report and 20-F Information 2024 are:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. Product pipeline risks: failure or delay in the delivery of our pipeline or launch of new medicines; failure to meet regulatory or ethical requirements for medicine development or approval

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. Commercialisation risks: pricing, affordability, access and competitive pressures; failures or delays in the quality or execution of the Group's commercial strategies

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3. Supply chain and business-execution risks: failure to maintain supply of compliant, quality medicines; failure in information technology or cybersecurity; failure to collect and manage data or AI in line with legal and regulatory requirements and strategic objectives

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4. Legal, regulatory and compliance risks: safety and efficacy of marketed medicines is questioned; adverse outcome of litigation and / or governmental investigations; IP risks related to our products

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5. Economic and financial risks: geopolitical and/or macroeconomic volatility disrupts the operation of our global business; failure to achieve strategic plans or meet targets or expectations

![Graphic](azn-20250630x6k001.jpg)

**Interim financial statements**

**Table 16: Condensed consolidated statement of comprehensive income: H1 2025**

---

| | | |
|:---|:---|:---|
| For the **half year** ended 30 June | **2025** | **2024** |
|  | **$m** | **$m** |
| *- Product Sales* | *26670* | *24629* |
| *- Alliance Revenue* | *1293* | *939* |
| Product Revenue | 27963 | 25568 |
| Collaboration Revenue | 82 | 49 |
| **Total Revenue** | **28045** | **25617** |
| Cost of sales | (4714) | (4401) |
| **Gross profit** | **23331** | **21216** |
| Distribution expense | (278) | (267) |
| Research and development expense | (6707) | (5791) |
| Selling, general and administrative expense | (9356) | (9424) |
| Other operating income and expense | 192 | 127 |
| **Operating profit** | **7182** | **5861** |
| Finance income | 149 | 211 |
| Finance expense | (785) | (856) |
| Share of after tax losses in associates and joint ventures | (17) | (19) |
| **Profit before tax** | **6529** | **5197** |
| Taxation | (1160) | (1089) |
| **Profit for the period** | **5369** | **4108** |
| **Other comprehensive income** |  |  |
| **Items that will not be reclassified to profit or loss:** |  |  |
| &nbsp;&nbsp;Remeasurement of the defined benefit pension liability | (30) | 101 |
| &nbsp;&nbsp;Net (losses)/gains on equity investments measured at fair value through other comprehensive income | (125) | 89 |
| &nbsp;&nbsp;Fair value movements related to own credit risk on bonds designated as fair value through profit or loss | -  | 12 |
| &nbsp;&nbsp;Tax on items that will not be reclassified to profit or loss | (3) | (27) |
|  | **(158)** | **175** |
| **Items that may be reclassified subsequently to profit or loss:** |  |  |
| &nbsp;&nbsp;Foreign exchange arising on consolidation | 2464 | (554) |
| &nbsp;&nbsp;Foreign exchange arising on designated liabilities in net investment hedges | 10 | (96) |
| &nbsp;&nbsp;Fair value movements on cash flow hedges | 273 | (138) |
| &nbsp;&nbsp;Fair value movements on cash flow hedges transferred to profit and loss | (315) | 102 |
| &nbsp;&nbsp;Fair value movements on derivatives designated in net investment hedges | (20) | 45 |
| &nbsp;&nbsp;Gains of hedging | 10 | 14 |
| &nbsp;&nbsp;Tax on items that may be reclassified subsequently to profit or loss | (52) | 38 |
|  | **2370** | **(589)** |
| **Other comprehensive income/(expense), net of tax** | **2212** | **(414)** |
| **Total comprehensive income for the period** | **7581** | **3694** |
| **Profit attributable to:** |  |  |
| Owners of the Parent | 5366 | 4106 |
| Non-controlling interests | 3 | 2 |
|  | **5369** | **4108** |
| **Total comprehensive income attributable to:** |  |  |
| Owners of the Parent | 7574 | 3692 |
| Non-controlling interests | 7 | 2 |
|  | **7581** | **3694** |
| ***Earnings per share*** |  |  |
| Basic earnings per $0.25 Ordinary Share | $3.46 | $2.65 |
| Diluted earnings per $0.25 Ordinary Share | $3.44 | $2.63 |
| Weighted average number of Ordinary Shares in issue (millions) | 1550 | 1549 |
| Diluted weighted average number of Ordinary Shares in issue (millions) | 1560 | 1560 |

---

![Graphic](azn-20250630x6k001.jpg)

**Table 17: Condensed consolidated statement of comprehensive income: Q2 2025**

---

| | | |
|:---|:---|:---|
| For the **quarter** ended 30 June | **Unreviewed** | **Unreviewed** |
|  | **2025** | **2024** |
|  | **$m** | **$m** |
| *- Product Sales* | *13795* | *12452* |
| *- Alliance Revenue* | *654* | *482* |
| Product Revenue | 14449 | 12934 |
| Collaboration Revenue | 8 | 4 |
| **Total Revenue** | **14457** | **12938** |
| Cost of sales | (2473) | (2183) |
| **Gross profit** | **11984** | **10755** |
| Distribution expense | (143) | (132) |
| Research and development expense | (3548) | (3008) |
| Selling, general and administrative expense | (4864) | (4929) |
| Other operating income and expense | 79 | 60 |
| **Operating profit** | **3508** | **2746** |
| Finance income | 68 | 100 |
| Finance expense | (439) | (443) |
| Share of after tax losses in associates and joint ventures | (10) | (6) |
| **Profit before tax** | **3127** | **2397** |
| Taxation | (679) | (469) |
| **Profit for the period** | **2448** | **1928** |
| **Other comprehensive income** |  |  |
| **Items that will not be reclassified to profit or loss:** |  |  |
| &nbsp;&nbsp;Remeasurement of the defined benefit pension liability | (81) | (43) |
| &nbsp;&nbsp;Net (losses)/gains on equity investments measured at fair value through other comprehensive income | (67) | 54 |
| &nbsp;&nbsp;Fair value movements related to own credit risk on bonds designated as fair value through profit or loss | -  | 12 |
| &nbsp;&nbsp;Tax on items that will not be reclassified to profit or loss | 14 | 12 |
|  | **(134)** | **35** |
| **Items that may be reclassified subsequently to profit or loss:** |  |  |
| &nbsp;&nbsp;Foreign exchange arising on consolidation | 1312 | (39) |
| &nbsp;&nbsp;Foreign exchange arising on designated liabilities in net investment hedges | (43) | 2 |
| &nbsp;&nbsp;Fair value movements on cash flow hedges | 201 | (52) |
| &nbsp;&nbsp;Fair value movements on cash flow hedges transferred to profit and loss | (213) | 32 |
| &nbsp;&nbsp;Fair value movements on derivatives designated in net investment hedges | (10) | 23 |
| &nbsp;&nbsp;Gains/(costs) of hedging | 18 | (1) |
| &nbsp;&nbsp;Tax on items that may be reclassified subsequently to profit or loss | (22) | 3 |
|  | **1243** | **(32)** |
| **Other comprehensive income, net of tax** | **1109** | **3** |
| **Total comprehensive income for the period** | **3557** | **1931** |
| **Profit attributable to:** |  |  |
| Owners of the Parent | 2450 | 1927 |
| Non-controlling interests | (2) | 1 |
|  | **2448** | **1928** |
| **Total comprehensive income attributable to:** |  |  |
| Owners of the Parent | 3556 | 1930 |
| Non-controlling interests | 1 | 1 |
|  | **3557** | **1931** |
| ***Earnings per share*** |  |  |
| Basic earnings per $0.25 Ordinary Share | $1.58 | $1.24 |
| Diluted earnings per $0.25 Ordinary Share | $1.57 | $1.24 |
| Weighted average number of Ordinary Shares in issue (millions) | 1550 | 1550 |
| Diluted weighted average number of Ordinary Shares in issue (millions) | 1559 | 1560 |

---

*The Q2 2025 and Q2 2024 information in respect of the three months ended 30 June 2025 and 30 June 2024 respectively included in the interim Financial Statements have not been reviewed by PricewaterhouseCoopers LLP*.

![Graphic](azn-20250630x6k001.jpg)

**Table 18: Condensed consolidated statement of financial position**

---

| | | | |
|:---|:---|:---|:---|
|  | **Reviewed At**<br>**30 Jun 2025**<br>**$m** | **Audited At**<br>**31 Dec 2024**<br>**$m** | **Reviewed At**<br>**30 Jun 2024**<br>**$m** |
| **Assets** |  |  |  |
| **Non-current assets** |  |  |  |
| Property, plant and equipment | 11637 | 10252 | 9630 |
| Right-of-use assets | 1592 | 1395 | 1203 |
| Goodwill | 21222 | 21025 | 21060 |
| Intangible assets | 37925 | 37177 | 39426 |
| Investments in associates and joint ventures | 276 | 268 | 264 |
| Other investments | 1863 | 1632 | 1607 |
| Derivative financial instruments | 509 | 182 | 217 |
| Other receivables | 1066 | 930 | 806 |
| Income tax receivable | 1137 | - | - |
| Deferred tax assets | 6256 | 5347 | 4734 |
|  | **83483** | **78208** | **78947** |
| **Current assets** |  |  |  |
| Inventories | 6467 | 5288 | 5667 |
| Trade and other receivables | 14168 | 12972 | 11047 |
| Other investments | 50 | 166 | 160 |
| Derivative financial instruments | 95 | 54 | 28 |
| Income tax receivable | 1001 | 1859 | 1575 |
| Intangible assets | 100 | - | - |
| Cash and cash equivalents | 7058 | 5488 | 6916 |
|  | **28939** | **25827** | **25393** |
| **Total assets** | **112422** | **104035** | **104340** |
| **Liabilities** |  |  |  |
| **Current liabilities** |  |  |  |
| Interest-bearing loans and borrowings | (6492) | (2337) | (5067) |
| Lease liabilities | (361) | (339) | (292) |
| Trade and other payables | (23986) | (22465) | (20463) |
| Derivative financial instruments | (100) | (50) | (51) |
| Provisions | (1168) | (1269) | (1168) |
| Income tax payable | (1429) | (1406) | (1525) |
|  | **(33536)** | **(27866)** | **(28566)** |
| **Non-current liabilities** |  |  |  |
| Interest-bearing loans and borrowings | (24714) | (26506) | (27225) |
| Lease liabilities | (1272) | (1113) | (949) |
| Derivative financial instruments | -  | (115) | (61) |
| Deferred tax liabilities | (3615) | (3305) | (3333) |
| Retirement benefit obligations | (1418) | (1330) | (1326) |
| Provisions | (972) | (921) | (1074) |
| Income tax payable | (485) | (238) | - |
| Other payables | (1600) | (1770) | (2208) |
|  | **(34076)** | **(35298)** | **(36176)** |
| **Total liabilities** | **(67612)** | **(63164)** | **(64742)** |
| **Net assets** | **44810** | **40871** | **39598** |
| **Equity** |  |  |  |
| Share capital | 388 | 388 | 388 |
| Share premium account | 35238 | 35226 | 35199 |
| Other reserves | 2070 | 2012 | 2078 |
| Retained earnings | 7023 | 3160 | 1847 |
| **Capital and reserves attributable to equity holders of the Parent** | **44719** | **40786** | **39512** |
| Non-controlling interests | 91 | 85 | 86 |
| **Total equity** | **44810** | **40871** | **39598** |

---

*The Condensed consolidated statements of financial position as at 30 June 2025 and 30 June 2024 have been reviewed by PricewaterhouseCoopers LLP. The Condensed consolidated statement of financial position as at 31 December 2024 has been audited by PricewaterhouseCoopers LLP*.

![Graphic](azn-20250630x6k001.jpg)

#### Table 19: Condensed consolidated statement of changes in equity

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
|  | <br>**Share**<br>**capital**<br>**$m** | <br>**Share**<br>**premium**<br>**account**<br>**$m** | <br>**Other**<br>**reserves**<br>**$m** | <br>**Retained**<br>**earnings**<br>**$m** | **Total**<br>**attributable**<br>**to owners**<br>**of the parent**<br>**$m** | <br>**Non-**<br>**controlling**<br>**interests**<br>**$m** | <br>**Total**<br>**equity**<br>**$m** |
| **At 1 Jan 2024** | **388** | **35188** | **2065** | **1502** | **39143** | **23** | **39166** |
| Profit for the period | - | - | - | 4106 | 4106 | 2 | 4108 |
| Other comprehensive expense | - | - | - | (414) | (414) | - | (414) |
| Transfer to other reserves | - | - | 13 | (13) | - | - | - |
| **Transactions with owners** |  |  |  |  |  |  |  |
| Dividends | - | - | - | (3052) | (3052) | - | (3052) |
| Issue of Ordinary Shares | - | 11 | - | - | 11 | - | 11 |
| Changes in non-controlling interests | - | - | - | - | - | 61 | 61 |
| Share-based payments charge for the period | - | - | - | 307 | 307 | - | 307 |
| Settlement of share plan awards | - | - | - | (589) | (589) | - | (589) |
| **Net movement** | - | 11 | 13 | 345 | 369 | 63 | 432 |
| **At 30 Jun 2024** | **388** | **35199** | **2078** | **1847** | **39512** | **86** | **39598** |
| **At 1 Jan 2025** | **388** | **35226** | **2012** | **3160** | **40786** | **85** | **40871** |
| Profit for the period | - | - | - | 5366 | 5366 | 3 | 5369 |
| Other comprehensive income | - | - | (34) | 2242 | 2208 | 4 | 2212 |
| Transfer to other reserves | - | - | 47 | (47) | - | - | - |
| **Transactions with owners** |  |  |  |  |  |  |  |
| Dividends | - | - | - | (3249) | (3249) | - | (3249) |
| Issue of Ordinary Shares | - | 12 | - | - | 12 | - | 12 |
| Changes in non-controlling interests | - | - | - | - | - | (1) | (1) |
| Movement in shares held by Employee Benefit Trusts | - | - | 45 | - | 45 | - | 45 |
| Share-based payments charge for the period | - | - | - | 357 | 357 | - | 357 |
| Settlement of share plan awards | - | - | - | (806) | (806) | - | (806) |
| **Net movement** | **-** | **12** | **58** | **3863** | **3933** | **6** | **3939** |
| **At 30 June 2025** | **388** | **35238** | **2070** | **7023** | **44719** | **91** | **44810** |

---

Transfer to other reserves includes $70m in respect of the opening balance on the Cash flow hedge reserve. The cash flow hedge reserve was previously disclosed within Retained earnings but from 2025 is disclosed within Other reserves.

![Graphic](azn-20250630x6k001.jpg)

#### Table 20: Condensed consolidated statement of cash flows: H1 2025

---

| | | |
|:---|:---|:---|
| For the **half year** ended 30 June | **2025** | **2024** |
|  | **$m** | **$m** |
| **Cash flows from operating activities** |  |  |
| Profit before tax | 6529 | 5197 |
| Finance income and expense | 636 | 645 |
| Share of after tax losses of associates and joint ventures | 17 | 19 |
| Depreciation, amortisation and impairment | 2673 | 2534 |
| Movement in working capital and short-term provisions | (771) | (584) |
| Gains on disposal of intangible assets | (87) | (21) |
| Fair value movements on contingent consideration arising from business combinations | (30) | 251 |
| Non-cash and other movements | 304 | (550) |
| **Cash generated from operations** | **9271** | **7491** |
| Interest paid | (623) | (583) |
| Tax paid | (1549) | (1337) |
| **Net cash inflow from operating activities** | **7099** | **5571** |
| **Cash flows from investing activities** |  |  |
| Acquisition of subsidiaries, net of cash acquired | -  | (2771) |
| Payment of contingent consideration from business combinations | (629) | (474) |
| Purchase of property, plant and equipment | (1088) | (799) |
| Disposal of property, plant and equipment | 10 | 53 |
| Purchase of intangible assets | (1804) | (1474) |
| Disposal of intangible assets | 95 | 75 |
| Purchase of non-current asset investments | (188) | (67) |
| Disposal of non-current asset investments | -  | 51 |
| Movement in short-term investments, fixed deposits and other investing instruments | 115 | 42 |
| Payments to associates and joint ventures | -  | (140) |
| Disposal of investments in associates and joint ventures | -  | 13 |
| Interest received | 128 | 206 |
| **Net cash outflow from investing activities** | **(3361)** | **(5285)** |
| **Net cash inflow before financing activities** | **3738** | **286** |
| **Cash flows from financing activities** |  |  |
| Proceeds from issue of share capital | 12 | 11 |
| Own shares purchased by Employee Benefit Trust | (489) | -  |
| Payments to acquire non-controlling interests | (2) | -  |
| Issue of loans and borrowings | 9 | 4976 |
| Repayment of loans and borrowings | (16) | (2643) |
| Dividends paid | (3357) | (3050) |
| Hedge contracts relating to dividend payments | 104 | (8) |
| Repayment of obligations under leases | (184) | (150) |
| Movement in short-term borrowings | 1734 | 2503 |
| Payment of Acerta Pharma share purchase liability | -  | (833) |
| **Net cash (outflow)/inflow from financing activities** | **(2189)** | **806** |
| Net increase in Cash and cash equivalents in the period | 1549 | 1092 |
| Cash and cash equivalents at the beginning of the period | 5429 | 5637 |
| Exchange rate effects | 54 | (52) |
| **Cash and cash equivalents at the end of the period** | **7032** | **6677** |
| **Cash and cash equivalents consist of:** |  |  |
| Cash and cash equivalents | 7058 | 6916 |
| Overdrafts | (26) | (239) |
|  | **7032** | **6677** |

---

![Graphic](azn-20250630x6k001.jpg)

**Responsibility statement of the directors in respect of the half-yearly financial report**

We confirm that to the best of our knowledge:

‒ the condensed consolidated Interim Financial Statements have been prepared in accordance with IAS 34 'Interim Financial Reporting' as issued by the International Accounting Standards Board (IASB), IAS 34 as adopted by the European Union and UK-adopted IAS 34;

‒ the half-yearly management report gives a true and fair view of the assets, liabilities, financial position and profit or loss of the company;

‒ the half-yearly management report includes a fair review of the information required by:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a) DTR 4.2.7R of the Disclosure and Transparency Rules, being an indication of important events that have occurred during the first six months of the financial year and their impact on the condensed consolidated Interim Financial Statements; and a description of the principal risks and uncertainties for the remaining six months of the year; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b) DTR 4.2.8R of the Disclosure and Transparency Rules, being related party transactions that have taken place in the first six months of the current financial year and that have materially affected the financial position or performance of the enterprise during that period; and any changes in the related party transactions described in the last annual report that could do so.

**The Board**

The Board of Directors that served during all or part of the six month period to 30 June 2025 and their respective responsibilities can be found on the Leadership team section of astrazeneca.com.

Approved by the Board and signed on its behalf by

Pascal Soriot

Chief Executive Officer

29 July 2025

![Graphic](azn-20250630x6k001.jpg)

**Independent review report to AstraZeneca PLC**

**Report on the Interim financial statements**

**Our conclusion**

We have reviewed AstraZeneca PLC's Interim financial statements (the "Interim financial statements") in the H1 and Q2 2025 results of AstraZeneca PLC for the six month period ended 30 June 2025 (the "period").

Based on our review, nothing has come to our attention that causes us to believe that the Interim financial statements are not prepared, in all material respects, in accordance with International Accounting Standard 34, 'Interim Financial Reporting' (IAS 34), as issued by the International Accounting Standards Board (IASB), IAS 34 as adopted by the European Union, UK-adopted IAS 34, and the Disclosure Guidance and Transparency Rules sourcebook of the United Kingdom's Financial Conduct Authority.

The Interim financial statements comprise:

---

| | |
|:---|:---|
| **–** | the Condensed consolidated statement of financial position as at 30 June 2025; |

---

---

| | |
|:---|:---|
| **–** | the Condensed consolidated statement of comprehensive income: H1 2025 for the period then ended; |

---

---

| | |
|:---|:---|
| **–** | the Condensed consolidated statement of changes in equity for the period then ended; |

---

---

| | |
|:---|:---|
| **–** | the Condensed consolidated statement of cash flows: H1 2025 for the period then ended; and |

---

---

| | |
|:---|:---|
| **–** | the explanatory notes to the Interim financial statements. |

---

The Interim financial statements included in the H1 and Q2 2025 results of AstraZeneca PLC have been prepared in accordance with International Accounting Standard 34, 'Interim Financial Reporting' (IAS 34), as issued by the International Accounting Standards Board (IASB), IAS 34 as adopted by the European Union, UK-adopted IAS 34, and the Disclosure Guidance and Transparency Rules sourcebook of the United Kingdom's Financial Conduct Authority.

**Basis for conclusion**

We conducted our review in accordance with International Standard on Review Engagements (UK) 2410, 'Review of Interim Financial Information Performed by the Independent Auditor of the Entity' issued by the Financial Reporting Council for use in the United Kingdom ("ISRE (UK) 2410"). A review of interim financial information consists of making enquiries, primarily of persons responsible for financial and accounting matters, and applying analytical and other review procedures.

A review is substantially less in scope than an audit conducted in accordance with International Standards on Auditing (UK) and, consequently, does not enable us to obtain assurance that we would become aware of all significant matters that might be identified in an audit. Accordingly, we do not express an audit opinion. We have read the other information contained in the H1 and Q2 2025 results and considered whether it contains any apparent misstatements or material inconsistencies with the information in the Interim financial statements.

**Conclusions relating to going concern**

Based on our review procedures, which are less extensive than those performed in an audit as described in the Basis for conclusion section of this report, nothing has come to our attention to suggest that the directors have inappropriately adopted the going concern basis of accounting or that the directors have identified material uncertainties relating to going concern that are not appropriately disclosed. This conclusion is based on the review procedures performed in accordance with ISRE (UK) 2410. However, future events or conditions may cause the group to cease to continue as a going concern.

![Graphic](azn-20250630x6k001.jpg)

**Responsibilities for the Interim financial statements and the review**

**Our responsibilities and those of the directors**

The H1 and Q2 2025 results, including the Interim financial statements, is the responsibility of, and has been approved by the directors. The directors are responsible for preparing the H1 and Q2 2025 results in accordance with the Disclosure Guidance and Transparency Rules sourcebook of the United Kingdom's Financial Conduct Authority. In preparing the H1 and Q2 2025 results, including the Interim financial statements, the directors are responsible for assessing the group's ability to continue as a going concern, disclosing, as applicable, matters related to going concern and using the going concern basis of accounting unless the directors either intend to liquidate the group or to cease operations, or have no realistic alternative but to do so.

Our responsibility is to express a conclusion on the Interim financial statements in the H1 and Q2 2025 results based on our review. Our conclusion, including our Conclusions relating to going concern, is based on procedures that are less extensive than audit procedures, as described in the Basis for conclusion paragraph of this report. This report, including the conclusion, has been prepared for and only for the company for the purpose of complying with the Disclosure Guidance and Transparency Rules sourcebook of the United Kingdom's Financial Conduct Authority and for no other purpose. We do not, in giving this conclusion, accept or assume responsibility for any other purpose or to any other person to whom this report is shown or into whose hands it may come save where expressly agreed by our prior consent in writing.

PricewaterhouseCoopers LLP

Chartered Accountants

London

29 July 2025

![Graphic](azn-20250630x6k001.jpg)

**Notes to the Interim financial statements**

#### Note 1: Basis of preparation and accounting policies
These unaudited Interim financial statements for the six months ended 30 June 2025 have been prepared in accordance with International Accounting Standard 34, 'Interim Financial Reporting' (IAS 34), as issued by the International Accounting Standards Board (IASB), IAS 34 as adopted by the European Union, UK-adopted IAS 34 and the Disclosure Guidance and Transparency Rules sourcebook of the United Kingdom's Financial Conduct Authority and with the requirements of the Companies Act 2006 as applicable to companies reporting under those standards.

The unaudited Interim financial statements for the six months ended 30 June 2025 were approved by the Board of Directors for publication on 29 July 2025.

This results announcement does not constitute statutory accounts of the Group within the meaning of sections 434(3) and 435(3) of the Companies Act 2006. The annual financial statements of the Group for the year ended 31 December 2024 were prepared in accordance with UK-adopted international accounting standards and with the requirements of the Companies Act 2006. The annual financial statements also comply fully with IFRS Accounting Standards as issued by the IASB and International Accounting Standards as adopted by the European Union. Except for the estimation of the interim income tax charge, the Interim financial statements have been prepared applying the accounting policies that were applied in the preparation of the Group's published consolidated financial statements for the year ended 31 December 2024.

The comparative figures for the financial year ended 31 December 2024 are not the Group's statutory accounts for that financial year. Those accounts have been reported on by the Group's auditors and will be delivered to the Registrar of Companies; their report was (i) unqualified, (ii) did not include a reference to any matters to which the auditors drew attention by way of emphasis without qualifying their report, and (iii) did not contain a statement under section 498(2) or (3) of the Companies Act 2006.

Product Revenue

Effective 1 January 2025, the Group has updated the presentation of Total Revenue on the face of the Statement of Comprehensive Income to include a new subtotal 'Product Revenue' representing the summation of Product Sales and Alliance Revenue.

Product Revenue and Collaboration Revenue form Total Revenue.

Product Sales and Alliance Revenue will continue to be presented separately, with the new subtotal providing additional aggregation of revenue types with similar characteristics, reflecting the growing importance of Alliance Revenue.

Full descriptions of Product Sales, Alliance Revenue and Collaboration Revenue are included from page 152 of the Group's Annual Report and Form 20-F Information 2024.

There are no changes to the Revenue accounting policy regarding the types of transactions recorded in each revenue category. The comparative period has been retrospectively adjusted to reflect the additional subtotal, resulting in total Product Revenue being reported for the half year ended 30 June 2024 of $25,568m.

Going concern

The Group has considerable financial resources available. As at 30 June 2025, the Group has $11.9bn in financial resources (cash and cash equivalent balances of $7.1bn and undrawn committed bank facilities of $4.9bn that are available until April 2030), with $6.9bn of borrowings due within one year. These facilities contain no financial covenants.

The Group has assessed the prospects of the Group over a period longer than the required 12 months from the date of Board approval of these consolidated financial statements, with no deterioration noted requiring a further extension of this review. The Group's revenues are largely derived from sales of medicines covered by patents, which provide a relatively high level of resilience and predictability to cash inflows, although government price interventions in response to budgetary constraints are expected to continue to adversely affect revenues in some of our significant markets. The Group, however, anticipates new revenue streams from both recently launched medicines and those in development, and the Group has a wide diversity of customers and suppliers across different geographic areas.

![Graphic](azn-20250630x6k001.jpg)

Consequently, the Directors believe that, overall, the Group is well placed to manage its business risks successfully. Accordingly, they continue to adopt the going concern basis in preparing the Interim financial statements.

Legal proceedings

The information contained in Note 5 updates the disclosures concerning legal proceedings and contingent liabilities in the Group's Annual Report and Form 20-F Information 2024.

#### Note 2: Intangible assets
The acquisition of EsoBiotec completed on 19 May 2025. The transaction is recorded as an asset acquisition based upon the concentration test permitted under IFRS 3 'Business Combinations', with consideration and net assets acquired of $403m, which included intangible assets acquired of $426m, current payables of $29m, $4m of cash and cash equivalents and current receivables of $2m. Contingent consideration of up to $575m could be paid on achievement of regulatory milestones, those liabilities will be recorded when the relevant regulatory milestone is achieved.

#### Note 3: Net debt
**Table 21: Net debt**

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
|  | **At 1 Jan**<br>**2025**<br>**$m** | **Cash**<br>**flow**<br>**$m** | **Non-cash**<br>**and other**<br>**$m** | **Exchange**<br>**movements**<br>**$m** | **At 30 Jun**<br>**2025**<br>**$m** |
| Non-current instalments of loans | (26506) | -  | 2431 | (639) | (24714) |
| Non-current instalments of leases | (1113) | -  | (106) | (53) | (1272) |
| **Total long-term debt** | **(27619)** | **-**  | **2325** | **(692)** | **(25986)** |
| Current instalments of loans | (2007) | 7 | (2461) | -  | (4461) |
| Current instalments of leases | (339) | 217 | (218) | (21) | (361) |
| Commercial paper | -  | (1470) | -  | -  | (1470) |
| Collateral received from derivative counterparties | (181) | (254) | -  | -  | (435) |
| Other short-term borrowings excluding overdrafts | (90) | (10) | -  | -  | (100) |
| Overdrafts | (59) | 34 | -  | (1) | (26) |
| **Total current debt** | **(2676)** | **(1476)** | **(2679)** | **(22)** | **(6853)** |
| **Gross borrowings** | **(30295)** | **(1476)** | **(354)** | **(714)** | **(32839)** |
| Net derivative financial instruments | 71 | (100) | 533 | -  | 504 |
| **Net borrowings** | **(30224)** | **(1576)** | **179** | **(714)** | **(32335)** |
| Cash and cash equivalents | 5488 | 1515 | -  | 55 | 7058 |
| Other investments - current | 166 | (115) | -  | (1) | 50 |
| **Cash and investments** | **5654** | **1400** | **-**  | **54** | **7108** |
| **Net debt** | **(24570)** | **(176)** | **179** | **(660)** | **(25227)** |

---

The table above provides an analysis of Net debt and a reconciliation of Net cash flow to the movement in Net debt. The Group monitors Net debt as part of its capital management policy as described in Note 28 of the Annual Report and Form 20-F Information 2024. Net debt is a non-GAAP financial measure.

Net debt increased by $657m in the six months to 30 June 2025 to $25,227m.

Details of the committed undrawn bank facilities are disclosed within the going concern section of Note 1. Non-cash movements in the period include fair value adjustments under IFRS 9 'Financial Instruments'.

The Group has agreements with some bank counterparties whereby the parties agree to post cash collateral on financial derivatives, for the benefit of the other, equivalent to the market valuation of the derivative positions above a predetermined threshold. The carrying value of such cash collateral held by the Group at 30 June 2025 was $435m (31 December 2024: $181m) and the carrying value of such cash collateral posted by the Group at 30 June 2025 was $32m (31 December 2024: $129m).

The equivalent GAAP measure to Net debt is 'liabilities arising from financing activities', which excludes the amounts for cash and overdrafts, other investments and non-financing derivatives shown.

During the six months ended 30 June 2025, Moody's upgraded the Group's solicited long term credit rating to A1 from A2, which occurred during Q1 2025. The short term rating remained at P-1. There were no changes to Standard and Poor's credit ratings (long term: A+; short term: A-1).

![Graphic](azn-20250630x6k001.jpg)

#### Note 4 : Financial Instruments
As detailed in the Group's most recent annual financial statements, the principal financial instruments consist of derivative financial instruments, other investments, trade and other receivables, cash and cash equivalents, trade and other payables, lease liabilities and interest-bearing loans and borrowings.

The Group has certain equity investments that are categorised as Level 3 in the fair value hierarchy that are held at $523m (31 December 2024: $353m) and for which a fair value loss of $35m has been recognised in the six months ended 30 June 2025 (H1 2024: fair value gain of $1m). In the absence of specific market data, these unlisted investments are held at fair value based on the cost of investment and adjusted as necessary for impairments and revaluations on new funding rounds, which are seen to approximate the fair value. All other fair value gains and/or losses that are presented in Net gains/(losses) on equity investments measured at fair value through other comprehensive income, in the Condensed consolidated statement of comprehensive income for the six months ended 30 June 2025 are Level 1 fair value measurements, valued based on quoted prices in active markets.

Financial instruments measured at fair value include $1,880m of other investments, $5,597m held in money-market funds and $504m of derivatives as at 30 June 2025. With the exception of derivatives being Level 2 fair valued, and certain equity instruments of $523m categorised as Level 3, the aforementioned balances are Level 1 fair valued. Financial instruments measured at amortised cost include $32m of cash collateral pledged to counterparties. The total fair value of Interest-bearing loans and borrowings as at 30 June 2025, which have a carrying value of $32,839m in the Condensed consolidated statement of financial position, was $32,203m.

**Table 22: Contingent consideration**

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **2025** | **2025** | **2025** | |
|  | **Diabetes** |  |  | |
|  | **alliance** | **Other** | **Total** | |
|  | **$m** | **$m** | **$m** | **2024**<br>**Total**<br>**$m** |
| **At 1 January** | **1309** | **442** | **1751** | **2137** |
| Additions through business combinations | -  | -  | -  | 198 |
| Settlements | (518) | (111) | (629) | (474) |
| Revaluations | (30) | -  | (30) | 251 |
| Discount unwind | 21 | 11 | 32 | 57 |
| **At 30 June** | **782** | **342** | **1124** | **2169** |

---

Contingent consideration arising from business combinations is fair valued using decision-tree analysis, with key inputs including the probability of success, consideration of potential delays and the expected levels of future revenues.

The contingent consideration balance relating to BMS's share of the global diabetes alliance of $782m (31 December 2024: $1,309m) would increase/decrease by $78m with an increase/decrease in sales of 10%, as compared with the current estimates.

#### Note 5: Legal proceedings and contingent liabilities
AstraZeneca is involved in various legal proceedings considered typical to its business, including litigation and investigations, including Government investigations, relating to product liability, commercial disputes, infringement of intellectual property (IP) rights, the validity of certain patents, anti-trust law and sales and marketing practices. The matters discussed below constitute the more significant developments since publication of the disclosures concerning legal proceedings in AstraZeneca's Annual Report and Form 20-F Information 2024 (the Disclosures). Information about the nature and facts of the cases is disclosed in accordance with IAS 37 'Provisions, Contingent Liabilities and Contingent Assets'.

As discussed in the Disclosures, the majority of claims involve highly complex issues. Often these issues are subject to substantial uncertainties and, therefore, the probability of a loss, if any, being sustained and/or an estimate of the amount of any loss is difficult to ascertain.

![Graphic](azn-20250630x6k001.jpg)

In cases that have been settled or adjudicated, or where quantifiable fines and penalties have been assessed and which are not subject to appeal, or where a loss is probable and we are able to make a reasonable estimate of the loss, AstraZeneca records the loss absorbed or makes a provision for its best estimate of the expected loss. The position could change over time and the estimates that the Group made, and upon which the Group have relied in calculating these provisions are inherently imprecise. There can, therefore, be no assurance that any losses that result from the outcome of any legal proceedings will not exceed the amount of the provisions that have been booked in the accounts. The major factors causing this uncertainty are described more fully in the Disclosures and herein.

AstraZeneca has full confidence in, and will vigorously defend and enforce, its IP.

**Matters disclosed in respect of the second quarter of 2025 and to 29 July 2025**

---

| | |
|:---|:---|
| **Patent litigation** |  |
| **Legal proceedings brought against AstraZeneca** | **Legal proceedings brought against AstraZeneca** |
| ***Forxiga* Patent Proceedings, UK***<br>Considered to be a contingent liability* | - In the UK, one of AstraZeneca's patents relating to Forxiga is being challenged by Generics (UK) Limited, Teva Pharmaceutical Industries Limited, and Glenmark Pharmaceuticals Europe Limited.<br>- Trial regarding patent validity occurred in March 2025. In April 2025, the UK Patents Court held the patent invalid. AstraZeneca appealed the decision. In July 2025, the UK Court of Appeal dismissed AstraZeneca's appeal and upheld the lower court's invalidity decision. In July 2025, AstraZeneca applied for permission to appeal to the UK Supreme Court.<br> - In March 2025 and onward, AstraZeneca applied for injunctions against generics manufacturers' at-risk sales of dapagliflozin products in the UK. AstraZeneca has obtained injunctions against generics manufacturers with UK marketing authorizations for dapagliflozin products through July 2025. In July 2025, AstraZeneca applied to the UK Supreme Court for injunctive relief.  |
| ***Lynparza Patent Proceedings, Canada****Considered to be a contingent liability* | -In July 2025, AstraZeneca was served with a Notice of Allegation from Cipla Ltd. challenging a patent relating to *Lynparza*.<br>- AstraZeneca is considering its next steps. |
| ***Tagrisso* Patent Proceedings, China***<br>Considered to be a contingent liability* | - In January 2025, an individual filed invalidity challenges against several Chinese patents protecting *Tagrisso*.<br>- A hearing before the Chinese Patent Office was held in July 2025. AstraZeneca is awaiting a decision. |
| **Legal proceedings brought by AstraZeneca** | **Legal proceedings brought by AstraZeneca** |
| ***Lokelma* Patent Proceedings, US** *Matter concluded* | - In August 2022, in response to Paragraph IV notices, AstraZeneca initiated ANDA litigation against five generic filers in the US District Court for the District of Delaware. AstraZeneca alleged that a generic version of *Lokelma* would infringe patents that are owned or licensed by AstraZeneca.<br>- AstraZeneca has entered into separate settlement agreements with the five generic manufacturers which resulted in dismissal of the corresponding litigations.<br>- This matter is now concluded. |
| ***Soliris* Patent Proceedings, Europe***<br>Considered to be a contingent asset* | - In March 2024, AstraZeneca filed motions for provisional measures against Amgen Pharmaceuticals Inc (Amgen) and Samsung Bioepis Co. Ltd. (Samsung) and their respective affiliates at the Hamburg Local Division of the Unified Patent Court (UPC) on the basis that Amgen's and Samsung's biosimilar eculizumab products infringe an AstraZeneca patent. In June 2024, the UPC denied AstraZeneca's motions. AstraZeneca appealed and in December 2024 the UPC appellate division denied AstraZeneca's appeal requesting provisional  |

---

![Graphic](azn-20250630x6k001.jpg)

---

| | |
|:---|:---|
| | measures. In June 2025, the UPC appellate division denied AstraZeneca's request for rehearing of the appeal.<br>- In parallel, Samsung and Amgen have filed oppositions to the patent at the European Patent Office. An oral hearing is scheduled for April 2026.<br>- In November 2024, Amgen filed a revocation action for the patent at the UPC Central Division in Milan. A hearing is scheduled for January 2026. |
| ***Soliris* Patent Proceedings, Canada***<br>Considered to be a contingent asset* | - In May 2023, AstraZeneca initiated patent litigation in Canada alleging that Amgen Pharmaceutical Inc.'s (Amgen) biosimilar eculizumab product will infringe AstraZeneca's patents. <br>-In September 2023, AstraZeneca initiated patent litigations in Canada alleging that Samsung Bioepis Co. Ltd.'s (Samsung) biosimilar eculizumab product will infringe AstraZeneca's patents. The filing of the litigation triggered an automatic 24-month stay of the approval of each defendant's biosimilar eculizumab product.<br>- Trial against Amgen occurred in January 2025. In May 2025, the Canadian court found AstraZeneca's patent would be infringed and enjoined Amgen from making, constructing, using, or selling the Amgen biosimilar eculizumab product in Canada until March 2027. Amgen has appealed this decision.<br>- In July and August 2023, in Canada, both Amgen and Samsung brought actions challenging the validity of AstraZeneca's patent relating to the use of eculizumab in treating aHUS. Trial with Amgen is scheduled for November 2025.<br>- In June 2025, AstraZeneca and Samsung settled the Canadian eculizumab patent matters. |
| ***Soliris* Patent Proceedings, UK**<br>*<br>Considered to be a contingent asset* | - May 2024, AstraZeneca initiated patent infringement proceedings against Amgen Ltd. (Amgen) and Samsung Bioepis UK Limited (Samsung) in the UK High Court of Justice alleging that their respective biosimilar eculizumab products infringe an AstraZeneca patent; on the same day, Samsung initiated a revocation action for the same patent.<br>- Trial was held in March 2025. In May 2025, the UK court issued a decision finding AstraZeneca's patent invalid and not infringed. AstraZeneca is evaluating its options. |
| ***Tagrisso* Patent Proceedings, Russia***<br>Considered to be a contingent asset* | - In August 2023, AstraZeneca filed lawsuits in the Arbitration Court of the Moscow region (Court) against the Russian Ministry of Health (MOH) and Axelpharm LLC for improper use of AstraZeneca information in the authorisation of a generic version of *Tagrisso*. The suit against the MOH was dismissed in July 2024, after two appeals. The case against Axelpharm was dismissed in September 2024, and AstraZeneca has appealed.<br> - In November 2023, Axelpharm sought a compulsory licence under a patent related to *Tagrisso*; the action remains pending. The Axelpharm patent on which the compulsory licensing action was based was held invalid by the Russian Patent and Trademark Office (PTO) in August 2024 following challenge by AstraZeneca. The PTO's decision was upheld in June 2025, following an appeal by Axelpharm<br> - In July 2024, AstraZeneca filed a patent infringement claim against Axelpharm in relation to a generic version of *Tagrisso*. The action was stayed by the court pending resolution of the compulsory licensing action.<br>- In August 2024, after AstraZeneca filed a complaint, the Federal Anti-Monopoly Service of Russia (FAS) initiated a case against Axelpharm and OncoTarget. In November 2024, the FAS found Axelpharm to have committed unfair competition, but not OncoTarget.  |

---

![Graphic](azn-20250630x6k001.jpg)

---

| | |
|:---|:---|
| | Axelpharm's appeal against the FAS's finding was upheld in June 2025. AstraZeneca has appealed against this ruling. |
| **Commercial litigation** |  |
| **Legal proceedings brought against AstraZeneca** | **Legal proceedings brought against AstraZeneca** |
| **Definiens, Germany***<br>Considered to be a contingent liability* | - In July 2020, AstraZeneca received a notice of arbitration filed with the German Institution of Arbitration from the sellers of Definiens AG (Sellers) regarding the 2014 share purchase agreement (SPA) between AstraZeneca and the Sellers. The Sellers claim that they are owed approximately $140m in earn-outs under the SPA. In December 2023, after an arbitration hearing, the arbitration panel made a final award of $46m in favour of the Sellers. <br>- In March 2024, AstraZeneca filed an application with the Bavarian Supreme Court (Court) to set aside the arbitration award.<br>- In April 2025, the Court ruled in favour of AstraZeneca, annulled the arbitration award, and referred the dispute back to the same arbitration panel for a second determination.<br>- In May 2025, the Sellers appealed the Court's decision to the German Federal Court of Justice. AstraZeneca also appealed the decision to refer the dispute back to the same arbitration panel. |
| ***Seroquel XR* Antitrust Litigation, US***<br>A provision has been taken* | - In 2019, AstraZeneca was named in several related complaints now proceeding in US District Court in Delaware (District Court), including several putative class action lawsuits that were purportedly brought on behalf of classes of direct purchasers or end payors of Seroquel XR, that allege AstraZeneca and generic drug manufacturers violated US antitrust laws when settling patent litigation related to Seroquel XR.<br>- In July 2022, the District Court dismissed claims relating to one of the generic manufacturers while allowing claims relating to the second generic manufacturer to proceed.<br>- In September 2024, AstraZeneca reached a settlement agreement with one of the plaintiff classes which the court approved.<br>-In May 2025, AstraZeneca resolved the matter with all remaining plaintiffs for a total payment of $97M. The Court must approve the class-related portion of the settlement before the matter is concluded. |
| **Syntimmune Milestone Litigation, US***<br>Considered to be a contingent liability* | -In connection with AstraZeneca's acquisition of Syntimmune, Inc. (Syntimmune) in December 2020, AstraZeneca was served with a lawsuit filed by the stockholders' representative for Syntimmune in Delaware state court that alleged, among other things, breaches of the 2018 merger agreement (Merger Agreement).<br>- The stockholders' representative alleges that AstraZeneca failed to meet its obligations under the Merger Agreement to use commercially reasonable efforts to achieve the milestones. AstraZeneca also filed a claim for breach of the representations in the Merger Agreement.<br>- A trial was held in July 2023.<br>- In September 2024, the court issued a partial decision, concluding that the first milestone in the amount of $130m was achieved, and that AstraZeneca had breached its contractual obligation to use commercially reasonable efforts to achieve the milestones. The court requested additional briefing regarding damages and further proceedings regarding AstraZeneca's claim for breach.<br>- In June 2025, the court issued a further decision awarding an additional $181m in damages on its September 2024 breach determination. Additional proceedings regarding AstraZeneca's claim for breach are ongoing. |

---

![Graphic](azn-20250630x6k001.jpg)

---

| | |
|:---|:---|
| **Government investigations and proceedings** |  |
| **Legal proceedings brought against AstraZeneca** | **Legal proceedings brought against AstraZeneca** |
| **Texas Qui Tam, US***<br>Considered to be a contingent liability* | - In December 2022, AstraZeneca was served with an unsealed civil lawsuit brought by qui tam relators on behalf of the State of Texas in Texas state court, which alleges that AstraZeneca engaged in unlawful marketing practices. <br>- In July 2025, the State of Texas sought to intervene in the matter.<br>- Trial is scheduled for December 2025. |
| **Legal proceedings brought by AstraZeneca** | **Legal proceedings brought by AstraZeneca** |
| **340B State Litigation, US***<br>Considered to be a contingent asset* | - AstraZeneca has filed lawsuits against Arkansas, Kansas, Louisiana, Maryland, Minnesota, Mississippi, Missouri, Nebraska, Utah, and West Virginia challenging the constitutionality of each state's 340B statute.<br>- In the Arkansas matter, trial is scheduled for September 2025 and the state has moved to dismiss AstraZeneca's complaint. In the separate Arkansas administrative proceeding, the commissioner issued a cease-and-desist order in April 2025 requiring AstraZeneca to pause its 340B policy in Arkansas. AstraZeneca has appealed this decision.<br>- In Kansas, after obtaining a stipulation from the state that AstraZeneca's policy does not violate the Kansas 340B statute, AstraZeneca agreed to dismiss its complaint.<br>- In Louisiana, the court granted the state's motion for summary judgment. AstraZeneca has filed an appeal.<br>- In Maryland, the state has moved to dismiss AstraZeneca's complaint and the court has denied AstraZeneca's preliminary injunction motion.<br>- In Minnesota, the court found that the defendant government officials do not have authority to enforce the law and accordingly dismissed AstraZeneca's complaint for lack of standing.<br>- In Missouri, the court granted in part and denied in part the state's motion to dismiss.<br>- In Mississippi, the court denied AstraZeneca's preliminary injunction motion. Trial is scheduled for March 2026.<br>- In Nebraska, AstraZeneca filed its complaint, and the case remains in the preliminary stages.<br>- In Utah, the state moved to dismiss AstraZeneca's complaint. The court stayed AstraZeneca's case pending resolution of a related preliminary injunction motion.<br>- In West Virginia, the matter is stayed pending an appeal of a related West Virginia litigation. |
| **Inflation Reduction Act Litigation, US***<br>Considered to be a contingent asset* | - In August 2023, AstraZeneca filed a lawsuit in the US District Court for the District of Delaware (District Court) against the US Department of Health and Human Services (HHS) challenging aspects of the drug price negotiation provisions of the Inflation Reduction Act and the implementing guidance and regulations. In March 2024, the District Court granted HHS' motions and dismissed AstraZeneca's lawsuit.<br>- In May 2025, the US Court of Appeals for the Third Circuit affirmed the District Court's dismissal of AstraZeneca's challenge. AstraZeneca intends to appeal. |
| **Other** |  |
| **Additional government inquiries**  |  |
| As is true for most, if not all, major prescription pharmaceutical companies, AstraZeneca is currently involved in multiple inquiries into drug marketing and pricing practices. In addition to the investigations described above, various  | As is true for most, if not all, major prescription pharmaceutical companies, AstraZeneca is currently involved in multiple inquiries into drug marketing and pricing practices. In addition to the investigations described above, various  |

---

![Graphic](azn-20250630x6k001.jpg)

---

| | |
|:---|:---|
| law enforcement offices have, from time to time, requested information from the Group. There have been no material developments in those matters. | law enforcement offices have, from time to time, requested information from the Group. There have been no material developments in those matters. |
| **Matters disclosed in respect of the first quarter of 2025 and to 29 April 2025, for which no updates disclosed in respect of the second quarter of 2025 and to 29 July 2025** | **Matters disclosed in respect of the first quarter of 2025 and to 29 April 2025, for which no updates disclosed in respect of the second quarter of 2025 and to 29 July 2025** |
| **Commercial litigation** |  |
| **Legal proceedings brought against AstraZeneca** | **Legal proceedings brought against AstraZeneca** |
| **Soliris Antitrust Class Action, US**<br>*Considered to be a contingent liability* | - In April 2025, AstraZeneca was named in a lawsuit filed in the US District Court for the District of Massachusetts alleging antitrust claims on behalf of a potential class of end payors for Soliris from March 2022.<br>- The plaintiff alleges that AstraZeneca violated federal and state antitrust and business practices laws by obtaining improper patents for Soliris, delaying biosimilar entry and improperly extending Soliris' market exclusivity. |
| **Viela Bio, Inc. Shareholder Litigation, US**<br>*Matter concluded* | - In February 2023, AstraZeneca was served with a lawsuit filed in the Delaware state court against AstraZeneca and certain officers (collectively, Defendants), on behalf of a putative class of Viela Bio, Inc. (Viela) shareholders. The complaint alleged that the Defendants breached their fiduciary duty to Viela shareholders in the course of Viela's 2021 merger with Horizon Therapeutics, plc.<br>- In July 2024, the Court granted with prejudice AstraZeneca's motion to dismiss.<br> - In August 2024, plaintiffs appealed the dismissal. <br> - In March 2025, the Delaware Supreme Court affirmed the dismissal. <br>- This matter is now concluded. |
| **Government investigations and proceedings** |  |
| **Legal proceedings brought against AstraZeneca** | **Legal proceedings brought against AstraZeneca** |
| ***Beyfortus* Civil Investigative Demand, US**<br>*Considered to be a contingent liability* | - In March 2025, AstraZeneca received a subpoena from the US Attorney's Office seeking certain records relating to *Beyfortus*. The subpoena requests that the Company produce various documents from January 2020 to present, including communications related to specific batches of Beyfortus, customer complaints, and FDA inspection reports. |
| **Shenzhen City Customs Office**<br>*<br>Considered to be a contingent liability* | - In relation to the illegal drug importation allegations, in April 2025, AstraZeneca received a second Appraisal Opinion from the Shenzhen City Customs Office regarding suspected unpaid importation taxes amounting to $1.6m.<br>- To the best of AstraZeneca's knowledge, the importation taxes referred to in the Appraisal Opinion relate to Enhertu.<br>- A fine of between one and five times the amount of unpaid importation taxes may also be levied if AstraZeneca is found liable. |
| **China Personal Information Infringement**<br>*<br>Considered to be a contingent liability* | - In relation to the personal information infringement allegation, in April 2025, AstraZeneca received a Notice of Transfer to the Prosecutor from the Shenzhen Bao'an District Public Security Bureau (the PSB) regarding suspected unlawful collection of personal information.<br>- The Company has been informed that there was no illegal gain to the Company resulting from personal information infringement. |

---

 

![Graphic](azn-20250630x6k001.jpg)

Note 6: Analysis of Revenue and Other operating income and expense

**Table 23: Product Sales year-on-year analysis: H1 2025**

The CER information in respect of H1 2025 included in the Interim financial statements has not been reviewed by PricewaterhouseCoopers LLP.

---

| | | | | | | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
|  | **World** | **World** | **World** | **US** | **US** | **Emerging Markets** | **Emerging Markets** | **Emerging Markets** | **Europe** | **Europe** | **Europe** | **Established RoW** | **Established RoW** | **Established RoW** |
| For the **half year** ended 30 June |  | **Change** | **Change** |  | **Change** |  | **Change** | **Change** |  | **Change** | **Change** |  | **Change** | **Change** |
|  | **$m** | **Act %** | **CER %**  | **$m** | **Act %**  | **$m** | **Act %** | **CER %**  | **$m** | **Act %** | **CER %**  | **$m** | **Act %** | **CER %**  |
| *Tagrisso*  | 3488 | 9 | 10 | 1439 | 12 | 1008 | 10 | 13 | 658 | 5 | 5 | 383 | 3 | 3 |
| *Imfinzi* | 2716 | 20 | 21 | 1572 | 31 | 294 | 20 | 28 | 537 | 17 | 17 | 313 | (11) | (11) |
| *Calquence* | 1634 | 8 | 9 | 1090 | 4 | 103 | 36 | 49 | 368 | 15 | 15 | 73 | 12 | 15 |
| *Lynparza* | 1564 | 8 | 9 | 689 | 14 | 323 | 1 | 4 | 425 | 7 | 6 | 127 | 1 | 2 |
| *Enhertu* | 428 | 72 | 76 | -  | -  | 292 | 82 | 88 | 94 | 65 | 63 | 42 | 35 | 41 |
| *Zoladex* | 567 | 3 | 6 | 9 | 16 | 442 | 7 | 10 | 72 | (7) | (8) | 44 | (10) | (9) |
| *Truqap* | 302 | n/m | n/m | 253 | 80 | 8 | n/m | n/m | 28 | n/m | n/m | 13 | n/m | n/m |
| *Imjudo* | 170 | 25 | 25 | 111 | 26 | 12 | 58 | 68 | 23 | 43 | 43 | 24 | (1) | (2) |
| Other Oncology | 216 | (10) | (8) | 4 | (63) | 146 | (7) | (5) | 10 | (16) | (16) | 56 | (6) | (7) |
| **Oncology** | **11085** | **14** | **15** | **5167** | **18** | **2628** | **14** | **19** | **2215** | **13** | **12** | **1075** | **(1)** | **-**  |
| *Farxiga* | 4206 | 11 | 13 | 803 | (7) | 1730 | 17 | 23 | 1448 | 17 | 17 | 225 | 7 | 7 |
| *Crestor* | 635 | 8 | 10 | 24 | 11 | 547 | 15 | 17 | -  | n/m | n/m | 64 | (9) | (8) |
| *Brilinta* | 520 | (22) | (21) | 271 | (23) | 137 | (18) | (16) | 107 | (21) | (21) | 5 | (39) | (34) |
| *Seloken* | 308 | (2) | 2 | -  | n/m | 298 | (3) | 1 | 8 | 34 | 38 | 2 | (9) | (5) |
| *Lokelma* | 328 | 31 | 32 | 144 | 25 | 63 | 50 | 54 | 56 | 36 | 36 | 65 | 27 | 26 |
| roxadustat | 150 | (8) | (7) | -  | -  | 150 | (8) | (7) | -  | -  | -  | -  | -  | -  |
| *Wainua* | 84 | n/m | n/m | 82 | n/m | 1 | -  | -  | 1 | -  | -  | -  | -  | -  |
| Other CVRM | 274 | (27) | (26) | 27 | (74) | 138 | 14 | 16 | 76 | (37) | (37) | 33 | 7 | 7 |
| **CVRM** | **6505** | **6** | **7** | **1351** | **(9)** | **3064** | **11** | **15** | **1696** | **9** | **9** | **394** | **6** | **6** |
| *Symbicort* | 1438 | (4) | (2) | 598 | -  | 400 | (11) | (8) | 272 | (5) | (5) | 168 | 7 | 10 |
| *Fasenra* | 920 | 18 | 18 | 556 | 16 | 52 | 26 | 32 | 229 | 19 | 19 | 83 | 19 | 20 |
| *Breztri* | 583 | 28 | 29 | 295 | 31 | 156 | 19 | 21 | 87 | 34 | 34 | 45 | 34 | 36 |
| *Tezspire* | 198 | 99 | n/m | -  | -  | 16 | n/m | n/m | 128 | n/m | n/m | 54 | 61 | 63 |
| *Pulmicort* | 264 | (30) | (28) | 4 | (57) | 208 | (34) | (32) | 34 | (8) | (7) | 18 | 8 | 11 |
| *Saphnelo* | 304 | 49 | 49 | 265 | 44 | 7 | n/m | n/m | 21 | n/m | n/m | 11 | 45 | 45 |
| *Airsupra* | 70 | n/m | n/m | 69 | n/m | 1 | n/m | n/m | -  | -  | -  | -  | -  | -  |
| Other R&I | 158 | (8) | (8) | 55 | 4 | 70 | (18) | (17) | 29 | (2) | (3) | 4 | (4) | -  |
| **R&I** | **3935** | **9** | **10** | **1842** | **18** | **910** | **(12)** | **(9)** | **800** | **18** | **17** | **383** | **19** | **21** |
| *Beyfortus* | 128 | n/m | n/m | 102 | 91 | -  | -  | -  | 24 | n/m | n/m | 2 | n/m | n/m |
| *Synagis* | 162 | (36) | (33) | (1) | (22) | 121 | (8) | (3) | 25 | (62) | (60) | 17 | (70) | (71) |
| *FluMist* | 10 | 20 | 16 | -  | n/m | -  | n/m | n/m | -  | n/m | n/m | 10 | n/m | n/m |
| Other V&I | 1 | (91) | (91) | -  | -  | -  | n/m | n/m | 1 | (91) | (91) | -  | n/m | n/m |
| **V&I** | **301** | **(7)** | **(5)** | **101** | **82** | **121** | **(7)** | **(3)** | **50** | **(39)** | **37** | **29** | **(49)** | **(50)** |
| *Ultomiris* | 2228 | 23 | 24 | 1272 | 23 | 113 | 71 | 82 | 498 | 21 | 21 | 345 | 17 | 17 |
| *Soliris* | 974 | (32) | (30) | 568 | (30) | 224 | (12) | (1) | 112 | (57) | (57) | 70 | (40) | (38) |
| *Strensiq* | 746 | 14 | 15 | 584 | 10 | 50 | 61 | 67 | 57 | 19 | 20 | 55 | 24 | 23 |
| *Koselugo*  | 275 | 11 | 13 | 106 | 5 | 76 | (9) | (5) | 71 | 58 | 58 | 22 | 25 | 25 |
| Other Rare Disease | 113 | 12 | 14 | 54 | 16 | 20 | 4 | 16 | 34 | 12 | 12 | 5 | 9 | 10 |
| **Rare Disease** | **4336** | **2** | **3** | **2584** | **3** | **483** | **6** | **16** | **772** | **(3)** | **(3)** | **497** | **4** | **4** |
| *Nexium* | 426 | (7) | (5) | 37 | (21) | 333 | 5 | 8 | 17 | (35) | (35) | 39 | (43) | (41) |
| Other | 82 | (19) | (18) | 3 | (46) | 59 | (12) | (11) | 18 | (32) | (33) | 2 | 8 | 7 |
| **Other Medicines** | **508** | **(9)** | **(7)** | **40** | **(23)** | **392** | **2** | **4** | **35** | **(34)** | **(34)** | **41** | **(41)** | **(40)** |
| **Total Medicines** | **26670** | **8** | **10** | **11085** | **10** | **7598** | **8** | **12** | **5568** | **8** | **8** | **2419** | **2** | **2** |

---

*The table provides an analysis of year-on-year Product Sales, with Actual and CER growth rates reflecting year-on-year growth*.

![Graphic](azn-20250630x6k001.jpg)

**Table 24: Product Sales year-on-year analysis: Q2 2025 (Unreviewed)**

The Q2 2025 information in respect of the three months ended 30 June 2025 included in the Interim financial statements has not been reviewed by PricewaterhouseCoopers LLP.

---

| | | | | | | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
|  | **World** | **World** | **World** | **US** | **US** | **Emerging Markets** | **Emerging Markets** | **Emerging Markets** | **Europe** | **Europe** | **Europe** | **Established RoW** | **Established RoW** | **Established RoW** |
| For the **half year** ended 30 June |  | **Change** | **Change** |  | **Change** |  | **Change** | **Change** |  | **Change** | **Change** |  | **Change** | **Change** |
|  | **$m** | **Act %** | **CER %**  | **$m** | **Act %**  | **$m** | **Act %** | **CER %**  | **$m** | **Act %** | **CER %**  | **$m** | **Act %** | **CER %**  |
| *Tagrisso*  | 1810 | 13 | 12 | 761 | 16 | 489 | 13 | 15 | 351 | 8 | 4 | 209 | 9 | 5 |
| *Imfinzi* | 1455 | 27 | 26 | 844 | 36 | 152 | 31 | 35 | 285 | 26 | 21 | 174 | (5) | (8) |
| *Calquence* | 872 | 10 | 10 | 583 | 5 | 49 | 36 | 43 | 198 | 19 | 14 | 42 | 27 | 28 |
| *Lynparza* | 838 | 13 | 11 | 378 | 18 | 162 | 6 | 7 | 229 | 11 | 7 | 69 | 5 | 2 |
| *Enhertu* | 230 | 81 | 82 | -  | -  | 156 | n/m | n/m | 51 | 63 | 56 | 23 | 24 | 28 |
| *Zoladex* | 284 | 4 | 5 | 4 | (8) | 219 | 9 | 11 | 38 | (9) | (13) | 23 | (9) | (11) |
| *Truqap* | 170 | 84 | 84 | 142 | 57 | 6 | n/m | n/m | 14 | n/m | n/m | 8 | n/m | n/m |
| *Imjudo* | 89 | 20 | 18 | 57 | 17 | 7 | 93 | 84 | 12 | 39 | 35 | 13 | -  | (4) |
| Other Oncology | 106 | (12) | (13) | 1 | (76) | 70 | (11) | (10) | 5 | (27) | (30) | 30 | -  | (5) |
| **Oncology** | **5854** | **18** | **17** | **2770** | **20** | **1310** | **19** | **22** | **1183** | **17** | **12** | **591** | **5** | **2** |
| *Farxiga* | 2150 | 11 | 10 | 420 | 6 | 859 | 13 | 15 | 765 | 13 | 8 | 106 | 3 | (1) |
| *Crestor* | 319 | 9 | 9 | 12 | 3 | 275 | 17 | 18 | -  | n/m | n/m | 32 | (10) | (13) |
| *Brilinta* | 215 | (37) | (38) | 99 | (48) | 63 | (20) | (20) | 51 | (26) | (29) | 2 | (46) | (39) |
| *Seloken* | 148 | (2) | 1 | -  | n/m | 143 | (2) | -  | 4 | 4 | 11 | 1 | (5) | (3) |
| *Lokelma* | 175 | 29 | 27 | 75 | 18 | 33 | 52 | 54 | 30 | 33 | 29 | 37 | 30 | 24 |
| roxadustat | 72 | (18) | (18) | -  | -  | 72 | (18) | (18) | -  | -  | -  | -  | -  | -  |
| *Wainua* | 44 | n/m | n/m | 43 | n/m | -  | -  | -  | 1 | -  | -  | -  | -  | -  |
| Other CVRM | 138 | (27) | (28) | 16 | (73) | 67 | 24 | 24 | 38 | (35) | (37) | 17 | (8) | (12) |
| **CVRM** | **3261** | **3** | **3** | **665** | **(10)** | **1512** | **9** | **11** | **889** | **5** | **1** | **195** | **2** | **(2)** |
| *Symbicort* | 715 | (1) | (1) | 319 | 7 | 168 | (15) | (14) | 137 | (5) | (8) | 91 | 11 | 11 |
| *Fasenra* | 502 | 19 | 18 | 307 | 14 | 26 | 33 | 36 | 125 | 27 | 22 | 44 | 20 | 18 |
| *Breztri* | 283 | 21 | 20 | 147 | 22 | 65 | 7 | 8 | 46 | 32 | 27 | 25 | 30 | 28 |
| *Tezspire* | 112 | 97 | 91 | -  | -  | 9 | n/m | n/m | 72 | n/m | n/m | 31 | 60 | 55 |
| *Pulmicort* | 106 | (32) | (32) | 1 | (58) | 81 | (35) | (36) | 15 | (14) | (18) | 9 | 2 | 2 |
| *Saphnelo* | 167 | 49 | 48 | 145 | 44 | 4 | n/m | n/m | 12 | n/m | n/m | 6 | 41 | 31 |
| *Airsupra* | 42 | n/m | n/m | 42 | n/m | -  | n/m | n/m | -  | -  | -  | -  | -  | -  |
| Other R&I | 61 | (23) | (24) | 16 | (35) | 28 | (25) | (25) | 15 | 2 | (3) | 2 | (8) | (7) |
| **R&I** | **1988** | **11** | **10** | **977** | **18** | **381** | **(14)** | **(13)** | **422** | **21** | **16** | **208** | **20** | **19** |
| *Beyfortus* | 98 | n/m | n/m | 73 | n/m | -  | -  | -  | 24 | n/m | n/m | 1 | 34 | 27 |
| *Synagis* | 49 | (39) | (37) | -  | n/m | 38 | (7) | (1) | -  | n/m | n/m | 11 | (68) | (69) |
| *FluMist* | 10 | n/m | n/m | -  | n/m | -  | -  | -  | -  | n/m | n/m | 10 | -  | -  |
| Other V&I | -  | n/m | n/m | -  | -  | -  | -  | -  | -  | n/m | n/m | -  | n/m | n/m |
| **V&I** | **157** | **40** | **42** | **73** | **n/m** | **38** | **(6)** | **(1)** | **24** | **n/m** | **n/m** | **22** | **(39)** | **(40)** |
| *Ultomiris* | 1177 | 25 | 23 | 667 | 21 | 61 | 76 | 86 | 270 | 29 | 24 | 179 | 18 | 12 |
| *Soliris* | 530 | (24) | (22) | 280 | (30) | 159 | 23 | 38 | 56 | (52) | (54) | 35 | (37) | (38) |
| *Strensiq* | 395 | 16 | 15 | 319 | 12 | 16 | 65 | 58 | 31 | 30 | 26 | 29 | 27 | 21 |
| *Koselugo*  | 137 | 20 | 18 | 52 | (5) | 36 | 51 | 50 | 37 | 42 | 37 | 12 | 28 | 22 |
| Other Rare Disease | 55 | 16 | 14 | 28 | 13 | 6 | 7 | 4 | 18 | 20 | 16 | 3 | 37 | 32 |
| **Rare Disease** | **2294** | **7** | **7** | **1346** | **3** | **278** | **37** | **48** | **412** | **5** | **1** | **258** | **7** | **2** |
| *Nexium* | 198 | (10) | (9) | 18 | (30) | 157 | 7 | 9 | 6 | (49) | (55) | 17 | (52) | (51) |
| Other | 43 | (10) | (11) | 3 | 12 | 29 | (12) | (11) | 10 | (12) | (18) | 1 | 4 | (3) |
| **Other Medicines** | **241** | **(10)** | **(9)** | **21** | **(26)** | **186** | **4** | **5** | **16** | **(32)** | **(38)** | **18** | **(50)** | **(50)** |
| **Total Medicines** | **13795** | **11** | **10** | **5852** | **12** | **3705** | **11** | **13** | **2946** | **12** | **8** | **1292** | **4** | **1** |

---

*The table provides an analysis of year-on-year Product Sales, with Actual and CER growth rates reflecting year-on-year growth*.

![Graphic](azn-20250630x6k001.jpg)

**Table 25: Alliance Revenue: H1 2025**

---

| | | |
|:---|:---|:---|
| For the **half year** ended 30 June |  |  |
|  | **2025** | **2024** |
|  | **$m** | **$m** |
| *Enhertu* | 834 | 683 |
| *Tezspire* | 285  | 180 |
| *Beyfortus* | 109  | 26 |
| *Datroway* | 14  | - |
| Other Alliance Revenue | 51  | 50 |
| **Total** | **1293** | **939** |

---

**Table 26: Collaboration Revenue: H1 2025**

---

| | | |
|:---|:---|:---|
| For the **half year** ended 30 June |  |  |
|  | **2025** | **2024** |
|  | **$m** | **$m** |
| *Farxiga*: sales milestones | 77  | 49 |
| Other Collaboration Revenue | 5  | - |
| **Total** | **82** | **49** |

---

#### Table 27: Other operating income and expense: H1 2025

---

| | | |
|:---|:---|:---|
| For the **half year** ended 30 June |  |  |
|  | **2025** | **2024** |
|  | **$m** | **$m** |
| **Total** | **192** | **127** |

---

![Graphic](azn-20250630x6k001.jpg)

**Other shareholder information**

**Financial calendar**

Announcement of 9M and Q3 2025 results: 6 November 2025 <br> Announcement of FY and Q4 2025 results: 10 February 2026

**Dividend payment dates**

Dividends are normally paid as follows:

– First interim:Announced with the half year results and paid in September

– Second interim:Announced with the full year results and paid in March

The ex-dividend dates shown below are for ordinary shares listed on the London Stock Exchange (LSE).

**Dividend dates**

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| | | | | |
|:---|:---|:---|:---|:---|
|  | **Announced** | **Ex-dividend date** | **Record date** | **Payment date** |
|  |  | **(LSE)** |  |  |
| FY 2025 First interim | 29 Jul 2025 | 7 Aug 2025 | 8 Aug 2025 | 8 Sep 2025 |

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For the ex-dividend dates of ordinary shares listed on the Stockholm Stock Exchange, and for American Depositary Receipts listed on NASDAQ, please check the notifications made by Euroclear Sweden AB, the Swedish Central Securities Depositary, and J.P. Morgan Chase Bank N.A., the US depositary. Contact details are below.

**Contact details**

For Investor Relations contacts, click here. For Media contacts, click here.

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**Addresses for correspondence**

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| | | | |
|:---|:---|:---|:---|
| **Registered office** | **Registrar and transfer office** | **Swedish Central Securities Depository** | **US depositary**  |
| 1 Francis Crick Avenue<br>Cambridge Biomedical Campus<br>Cambridge<br>CB2 0AA | Equiniti Limited<br>Aspect House<br>Spencer Road<br>Lancing<br>West Sussex<br>BN99 6DA | Euroclear Sweden AB<br>PO Box 191<br>SE-101 23 Stockholm | J.P. Morgan Chase Bank N.A.<br>EQ Shareowner Services<br>P.O. Box 64504<br>St. Paul<br>MN 55164-0504 |
| UK | UK | Sweden | US |
| +44 (0) 20 3749 5000 | 0800 389 1580 | +46 (0) 8 402 9000 | +1 (888) 697 8018 (US only) |
|  | +44 (0) 121 415 7033 |  | +1 (651) 453 2128 |

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**Trademarks**

Trademarks of the AstraZeneca group of companies appear throughout this document in italics. Medical publications also appear throughout the document in italics. AstraZeneca, the AstraZeneca logotype and the AstraZeneca symbol are all trademarks of the AstraZeneca group of companies. Trademarks of companies other than AstraZeneca that appear in this document include: *Beyfortus*, a trademark of Sanofi Pasteur Inc.; *Enhertu* and *Datroway*, trademarks of Daiichi Sankyo; *Seloken*, owned by AstraZeneca or Taiyo Pharma Co., Ltd (depending on geography); *Synagis*, owned by AstraZeneca or Sobi aka Swedish Orphan Biovitrum AB (publ). (depending on geography); and *Tezspire*, a trademark of Amgen, Inc.

Information on or accessible through AstraZeneca's websites, including astrazeneca.com, does not form part of and is not incorporated into this announcement.

![Graphic](azn-20250630x6k001.jpg)

**AstraZeneca**

AstraZeneca (LSE/STO/Nasdaq: AZN) is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines in Oncology, Rare Disease, and BioPharmaceuticals, including Cardiovascular, Renal & Metabolism, and Respiratory & Immunology. Based in Cambridge, UK, AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. Please visit astrazeneca.com and follow the Company on Social Media @AstraZeneca.

**Cautionary statements regarding forward-looking statements**

In order, among other things, to utilise the 'safe harbour' provisions of the US Private Securities Litigation Reform Act of 1995, AstraZeneca (hereafter 'the Group') provides the following cautionary statement:

This document contains certain forward-looking statements with respect to the operations, performance and financial condition of the Group, including, among other things, statements about expected revenues, margins, earnings per share or other financial or other measures. Although the Group believes its expectations are based on reasonable assumptions, any forward-looking statements, by their very nature, involve risks and uncertainties and may be influenced by factors that could cause actual outcomes and results to be materially different from those predicted. The forward-looking statements reflect knowledge and information available at the date of preparation of this document and the Group undertakes no obligation to update these forward-looking statements. The Group identifies the forward-looking statements by using the words 'anticipates', 'believes', 'expects', 'intends' and similar expressions in such statements. Important factors that could cause actual results to differ materially from those contained in forward-looking statements, certain of which are beyond the Group's control, include, among other things:

‒ the risk of failure or delay in delivery of pipeline or launch of new medicines;

‒ the risk of failure to meet regulatory or ethical requirements for medicine development or approval;

‒ the risk of failures or delays in the quality or execution of the Group's commercial strategies;

‒ the risk of pricing, affordability, access and competitive pressures;

‒ the risk of failure to maintain supply of compliant, quality medicines;

‒ the risk of illegal trade in the Group's medicines;

‒ the impact of reliance on third-party goods and services;

‒ the risk of failure in information technology or cybersecurity;

‒ the risk of failure of critical processes;

‒ the risk of failure to collect and manage data and artificial intelligence in line with legal and regulatory requirements and strategic objectives;

‒ the risk of failure to attract, develop, engage and retain a diverse, talented and capable workforce;

‒ the risk of failure to meet our sustainability targets, regulatory requirements and stakeholder expectations with respect to the environment;

‒ the risk of the safety and efficacy of marketed medicines being questioned;

‒ the risk of adverse outcome of litigation and/or governmental investigations;

‒ intellectual property risks related to the Group's products;

‒ the risk of failure to achieve strategic plans or meet targets or expectations;

‒ the risk of geopolitical and/or macroeconomic volatility disrupting the operation of our global business;

‒ the risk of failure in internal control, financial reporting or the occurrence of fraud; and

‒ the risk of unexpected deterioration in the Group's financial position.

![Graphic](azn-20250630x6k001.jpg)

**Glossary**

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| | | | |
|:---|:---|:---|:---|
| 1L, 2L, etc | first line, second line, etc | HCC | hepatocellular carcinoma |
| ABC | advanced breast cancer | HER2 / +/- /low /m | human epidermal growth factor receptor 2 gene / positive / negative / low expression / gene mutant |
| aHUS | atypical haemolytic uraemic syndrome | HES | hyper-eosinophilic syndrome |
| AL | amyloid light chain | HF/ pEF / rEF | heart failure / with preserved ejection fraction / with reduced ejection fraction |
| ASCO | American Society of Clinical Oncology | hMPV | human metapneumovirus |
| ATS | American Thoracic Society | HR / + / - | hormone receptor / positive / negative |
| BICLA | British Isles Lupus Assessment Group-based Composite Lupus Assessment | HSCT-TMA | hematopoietic stem cell transplantation-associated thrombotic microangiopathy |
| *BRCA* / m | breast cancer gene / mutation | ICS | inhaled corticosteroid |
| BTC | biliary tract cancer | IL-5 | interleukin-5 |
| BTK / i | bruton tyrosine kinase / inhibitor | LABA | long-acting beta-agonist |
| CDK4 | cyclin-dependent kinase 4 | LAMA | long-acting muscarinic-agonist |
| CI | confidence interval | LDH | lactic dehydrogenase |
| CHMP | Committee for Medicinal Products for Human Use (EU) | MCL | mantle cell lymphoma |
| CKD | chronic kidney disease | mCRPC | metastatic castration-resistant prostate cancer |
| CLL | chronic lymphocytic leukaemia | MET | mesenchymal-epithelial transition |
| CN | China | MIBC | muscle-invasive bladder cancer |
| COPD | chronic obstructive pulmonary disease | n/m | growth rate not meaningful |
| CSPC | castration-sensitive prostate cancer | NGP | next-generation propellant |
| CVRM | Cardiovascular, Renal and Metabolism | NMOSD | neuromyelitis optica spectrum disorder |
| EBITDA | earnings before interest, tax, depreciation and amortisation | NRDL | National Reimbursement Drug List |
| EFS | event free survival | NSCLC | non-small cell lung cancer |
| *EGFR* / m | epidermal growth factor receptor gene / mutation | OS | overall survival |
| EGPA | eosinophilic granulomatosis with polyangiitis | PARP | poly ADP ribose polymerase |
| EHA | European Hematology Association | pCR | pathologic complete response |
| EPS | earnings per share | PFS | progression free survival |
| *ESR1* / m | oestrogen receptor 1 gene / mutation | PNH | paroxysmal nocturnal haemoglobinuria |
| EVH | extravascular haemolysis | R&D | research and development |
| FDA | US Food and Drug Administration | RSV | respiratory syncytial virus |
| FDC | fixed dose combination | SCLC | small cell lung cancer |
| FLOT | fluorouracil, oxaliplatin and docetaxel | SG&A | sales, general and administration |
| GAAP | Generally Accepted Accounting Principles | SGLT2 | sodium-glucose cotransporter 2 |
| GEJ | gastro oesophageal junction | SLE | systemic lupus erythematosus |
| GI | gastrointestinal | THP | a treatment regimen: docetaxel, trastuzumab and pertuzumab |
| gMG | generalised myasthenia gravis | TMA | thrombotic microangiopathy |

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![Graphic](azn-20250630x6k001.jpg)

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

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| | | |
|:---|:---|:---|
|  | AstraZeneca PLC | AstraZeneca PLC |
| Date: 29<sup>th</sup> July, 2025 | By: | /s/ Matthew Bowden |
|  | Name: | Matthew Bowden |
|  | Title: | Company Secretary |

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