# EDGAR Filing Document

**Accession Number:** 0000944809
**File Stem:** 0001193125-26-117642
**Filing Date:** 2026-3
**Character Count:** 5683
**Document Hash:** bda3c7cdb286ceea5d017965ccaae2c7
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-26-117642.hdr.sgml**: 20260320

**ACCESSION NUMBER**: 0001193125-26-117642

**CONFORMED SUBMISSION TYPE**: 3

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20260318

**FILED AS OF DATE**: 20260320

**DATE AS OF CHANGE**: 20260320

**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** UPPALURI SUBBARAO V
- **CENTRAL INDEX KEY:** 0001389406

**ORGANIZATION NAME:**

**FILING VALUES:**
- **FORM TYPE:** 3
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-33528
- **FILM NUMBER:** 26778331

**MAIL ADDRESS:**
- **STREET 1:** 4400 BISCAYNE BOULEVARD, SUITE 1500
- **CITY:** MIAMI
- **STATE:** FL
- **ZIP:** 33137
**ISSUER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** OPKO HEALTH, INC.
- **CENTRAL INDEX KEY:** 0000944809
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 752402409
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**BUSINESS ADDRESS:**
- **STREET 1:** 4400 BISCAYNE BLVD.
- **CITY:** MIAMI
- **STATE:** FL
- **ZIP:** 33137
- **BUSINESS PHONE:** 305-575-4181

**MAIL ADDRESS:**
- **STREET 1:** 4400 BISCAYNE BLVD.
- **CITY:** MIAMI
- **STATE:** FL
- **ZIP:** 33137

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Opko Health, Inc.
- **DATE OF NAME CHANGE:** 20070621

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** eXegenics Inc
- **DATE OF NAME CHANGE:** 20040505

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** EXEGENICS INC
- **DATE OF NAME CHANGE:** 20011114

### UNITED STATES SECURITIES AND EXCHANGE COMMISSION
**Washington, D.C. 20549**

## FORM 3

### INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>UPPALURI SUBBARAO V<br><sub>(Last) (First) (Middle)</sub><br>OPKO HEALTH, INC.<br>4400 BISCAYNE BLVD.<br><sub>(Street)</sub><br>MIAMI, FL 33137<br><sub>(City) (State) (Zip)</sub> | **3. Issuer Name and Ticker or Trading Symbol**<br>OPKO HEALTH, INC. [ OPK ] | **5. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  |
| **2. Date of Event Requiring Statement (Month/Day/Year)**<br>2026-03-18 | **4. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[X] Director   [ ] 10% Owner<br>[ ] Officer (give title below)   [ ] Other (specify below)<br>_ _ | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[X] Form filed by One Reporting Person<br>[ ] Form filed by More than One Reporting Person |

---

## Table I - Non-Derivative Securities Beneficially Owned

---

|  |  |  |  |
| --- | --- | --- | --- |
| 1. Title of Security | 2. Amount of Securities Beneficially Owned | 3. Ownership Form | 4. Nature of Indirect Beneficial Ownership |
| Common Stock | 622817 | D |  |
| Common Stock | 2000000 | I | See Footnote<sup>(1)</sup> |
| Common Stock | 500000 | I | See Footnore<sup>(2)</sup> |
| Common Stock | 36000 | I | See Footnote<sup>(3)</sup> |

---

## Table II - Derivative Securities Beneficially Owned

---

|  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- |
| 1. Title of Derivative Security | 2. Date Exercisable and Expiration Date (Month/Day/Year) | 2. Date Exercisable and Expiration Date (Month/Day/Year) | 3. Title and Amount of Underlying Securities | 3. Title and Amount of Underlying Securities | 4. Conversion or Exercise Price | 5. Ownership Form | 6. Nature of Indirect Beneficial Ownership |
| 1. Title of Derivative Security | Date Exercisable | Expiration Date | Title | Amount or Number of Shares | 4. Conversion or Exercise Price | 5. Ownership Form | 6. Nature of Indirect Beneficial Ownership |
|  |  |  |  |  |  |  |  |

---

### Footnotes:

(1) Uppaluri Investments, LLC ("Uppaluri Investments"), owns these shares. Dr. Uppaluri is the Manager of Uppaluri Investments. Each of the Uppaluri 2012 Family Trust ("2012 Trust") and the Ajay Uppaluri 2020 Gift Trust ("2020 Trust") owns 50% of Uppaluri Investments. The 2012 Trust is for the benefit of Dr. Uppaluri's spouse, Anita Uppaluri, and she is the trustee. The 2020 Trust is for the benefit of Dr. Uppaluri's son, Ajay Uppaluri, and Dr. Uppaluri and his spouse are co-trustees. Dr. Uppaluri disclaims beneficial ownership of the shares held by Uppaluri Investments except to the extent of his pecuniary interest therein.

(2) The shares are owned by the 2020 Trust, which is for the benefit of Ajay Uppaluri. Dr. Uppaluri and his spouse are co-trustees. Dr. Uppaluri disclaims beneficial ownership of the shares held by the 2020 Trust, except to the extent of his pecuniary interest therein.

(3) The shares are owned by Dr. Uppaluri's spouse. Dr. Uppaluri disclaims beneficial ownership of the shares held by his spouse, except to the extent of his pecuniary interest therein.

**Signature:** /s/ Subbarao V. Uppaluri  
**Date:** 2026-03-20

### Remarks:

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

**Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.**