# EDGAR Filing Document

**Accession Number:** 0001314966
**File Stem:** 0001410368-25-032232
**Filing Date:** 2025-11
**Character Count:** 150333
**Document Hash:** 8d0138fcaa4bf0726bac441f8b60899b
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001410368-25-032232.hdr.sgml**: 20251126

**ACCESSION NUMBER**: 0001410368-25-032232

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20250930

**FILED AS OF DATE**: 20251126

**DATE AS OF CHANGE**: 20251126

**PERIOD START**: 20251231

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** BlackRock Health Sciences Trust
- **CENTRAL INDEX KEY:** 0001314966

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-21702
- **FILM NUMBER:** 251525963

**BUSINESS ADDRESS:**
- **STREET 1:** 100 BELLEVUE PARKWAY
- **CITY:** WILMINGTON
- **STATE:** DE
- **ZIP:** 19809
- **BUSINESS PHONE:** (888) 825-2257

**MAIL ADDRESS:**
- **STREET 1:** 100 BELLEVUE PARKWAY
- **CITY:** WILMINGTON
- **STATE:** DE
- **ZIP:** 19809

## Nport-Ex

September 30, 2025

2025 Quarterly Report <br>&nbsp;&nbsp;&nbsp;&nbsp;(Unaudited)<br>

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

**BlackRock Health Sciences Trust (BME)**<br>

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

**Not FDIC Insured • May Lose Value • No Bank Guarantee**<br>

------

Schedule of Investments (unaudited)

September 30, 2025

**BlackRock Health Sciences Trust (BME)** 

**(Percentages shown are based on Net Assets)**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

---

| | | |
|:---|:---|:---|
| *Security* | <br>*Shares*<br>| *Value* |
| **Common Stocks** | **Common Stocks** | **Common Stocks** |
| **Biotechnology — 25.8%** | **Biotechnology — 25.8%** |  |
| 4D Molecular Therapeutics, Inc.<sup>(a)</sup> | 11778 | &nbsp;&nbsp; $102351 |
| AbbVie, Inc.<sup>(b)</sup> | 106461 | &nbsp;&nbsp; 24649980 |
| Alkermes PLC<sup>(a)</sup> | 12700 | &nbsp;&nbsp; 381000 |
| Allogene Therapeutics, Inc.<sup>(a)(c)</sup> | 108101 | &nbsp;&nbsp; 134045 |
| Alnylam Pharmaceuticals, Inc.<sup>(a)</sup> | 31166 | &nbsp;&nbsp; 14211695 |
| Amgen, Inc.<sup>(b)</sup> | 59717 | &nbsp;&nbsp; 16852137 |
| Arcellx, Inc.<sup>(a)</sup> | 16531 | &nbsp;&nbsp; 1357195 |
| Arcus Biosciences, Inc.<sup>(a)</sup> | 26855 | &nbsp;&nbsp; 365228 |
| Argenx SE, ADR<sup>(a)</sup> | 5763 | &nbsp;&nbsp; 4250558 |
| Ascendis Pharma A/S, ADR<sup>(a)</sup> | 7949 | &nbsp;&nbsp; 1580341 |
| Autolus Therapeutics PLC, ADR<sup>(a)</sup> | 64258 | &nbsp;&nbsp; 104741 |
| Avidity Biosciences, Inc.<sup>(a)</sup> | 8950 | &nbsp;&nbsp; 389952 |
| Beam Therapeutics, Inc.<sup>(a)</sup> | 14977 | &nbsp;&nbsp; 363492 |
| Biogen, Inc.<sup>(a)</sup> | 29185 | &nbsp;&nbsp; 4088235 |
| Biohaven Ltd.<sup>(a)</sup> | 18429 | &nbsp;&nbsp; 276619 |
| BioMarin Pharmaceutical, Inc.<sup>(a)</sup> | 30316 | &nbsp;&nbsp; 1641915 |
| BioNTech SE, ADR<sup>(a)</sup> | 3788 | &nbsp;&nbsp; 373573 |
| &nbsp;&nbsp;&nbsp; Bridgebio Oncology Therapeutics, Inc., (Acquired <br> 08/08/25, Cost: $167,000)<sup>(a)(d)</sup><br>| 15582 | &nbsp;&nbsp; 180440 |
| BridgeBio Oncology Therapeutics, Inc.<sup>(a)(c)</sup> | 61530 | &nbsp;&nbsp; 712517 |
| Bridgebio Pharma, Inc.<sup>(a)</sup> | 18507 | &nbsp;&nbsp; 961254 |
| CG oncology, Inc.<sup>(a)</sup> | 5223 | &nbsp;&nbsp; 210382 |
| Denali Therapeutics, Inc.<sup>(a)</sup> | 20283 | &nbsp;&nbsp; 294509 |
| Disc Medicine, Inc.<sup>(a)</sup> | 7717 | &nbsp;&nbsp; 509939 |
| Dyne Therapeutics, Inc.<sup>(a)</sup> | 24506 | &nbsp;&nbsp; 310001 |
| Exact Sciences Corp.<sup>(a)</sup> | 49509 | &nbsp;&nbsp; 2708637 |
| Exelixis, Inc.<sup>(a)</sup> | 27330 | &nbsp;&nbsp; 1128729 |
| Gilead Sciences, Inc. | 89782 | &nbsp;&nbsp; 9965802 |
| Incyte Corp.<sup>(a)</sup> | 33103 | &nbsp;&nbsp; 2807465 |
| Insmed, Inc.<sup>(a)</sup> | 52511 | &nbsp;&nbsp; 7562109 |
| Ionis Pharmaceuticals, Inc.<sup>(a)</sup> | 15357 | &nbsp;&nbsp; 1004655 |
| Kymera Therapeutics, Inc.<sup>(a)</sup> | 4830 | &nbsp;&nbsp; 273378 |
| Legend Biotech Corp., ADR<sup>(a)</sup> | 11174 | &nbsp;&nbsp; 364384 |
| Merus NV<sup>(a)</sup> | 18404 | &nbsp;&nbsp; 1732737 |
| Moderna, Inc.<sup>(a)</sup> | 32542 | &nbsp;&nbsp; 840560 |
| Natera, Inc.<sup>(a)</sup> | 12117 | &nbsp;&nbsp; 1950473 |
| Neurocrine Biosciences, Inc.<sup>(a)</sup> | 11545 | &nbsp;&nbsp; 1620687 |
| Nuvalent, Inc., Class A<sup>(a)</sup> | 29333 | &nbsp;&nbsp; 2536718 |
| Protagonist Therapeutics, Inc.<sup>(a)</sup> | 32859 | &nbsp;&nbsp; 2182823 |
| PTC Therapeutics, Inc.<sup>(a)</sup> | 12726 | &nbsp;&nbsp; 780995 |
| Regeneron Pharmaceuticals, Inc. | 8927 | &nbsp;&nbsp; 5019384 |
| REGENXBIO, Inc.<sup>(a)</sup> | 18875 | &nbsp;&nbsp; 182144 |
| Rhythm Pharmaceuticals, Inc.<sup>(a)</sup> | 55078 | &nbsp;&nbsp; 5562327 |
| Roivant Sciences Ltd.<sup>(a)</sup> | 42251 | &nbsp;&nbsp; 639258 |
| Scholar Rock Holding Corp.<sup>(a)</sup> | 14670 | &nbsp;&nbsp; 546311 |
| Stoke Therapeutics, Inc.<sup>(a)</sup> | 69330 | &nbsp;&nbsp; 1629255 |
| Summit Therapeutics, Inc.<sup>(a)(c)</sup> | 24508 | &nbsp;&nbsp; 506335 |
| TScan Therapeutics, Inc.<sup>(a)</sup> | 49480 | &nbsp;&nbsp; 90054 |
| United Therapeutics Corp.<sup>(a)</sup> | 4080 | &nbsp;&nbsp; 1710377 |
| Upstream Bio, Inc.<sup>(a)(c)</sup> | 17345 | &nbsp;&nbsp; 326259 |
| Vaxcyte, Inc.<sup>(a)</sup> | 7730 | &nbsp;&nbsp; 278435 |
| Vertex Pharmaceuticals, Inc.<sup>(a)</sup> | 12835 | &nbsp;&nbsp; 5026699 |
| Viking Therapeutics, Inc.<sup>(a)</sup> | 9491 | &nbsp;&nbsp; 249423 |
| Vir Biotechnology, Inc.<sup>(a)</sup> | 20570 | &nbsp;&nbsp; 117455 |
| Voyager Therapeutics, Inc.<sup>(a)</sup> | 32205 | &nbsp;&nbsp; 150397 |
| Zealand Pharma A/S<sup>(a)</sup> | 7367 | &nbsp;&nbsp; 543280 |
|  |  | &nbsp;&nbsp; 134339644 |
| **Health Care Equipment & Supplies — 28.0%** | **Health Care Equipment & Supplies — 28.0%** |  |
| Abbott Laboratories<sup>(b)</sup> | 231527 | &nbsp;&nbsp; 31010726 |
| Alcon AG<sup>(c)</sup> | 5895 | &nbsp;&nbsp; 439236 |

---

---

| | | |
|:---|:---|:---|
| *Security* | <br> *Shares*<br>| *Value* |
| **Health Care Equipment & Supplies (continued)** | **Health Care Equipment & Supplies (continued)** |  |
| Becton Dickinson & Co. | 38538 | &nbsp;&nbsp; $7213158 |
| Boston Scientific Corp.<sup>(a)(b)</sup> | 215674 | &nbsp;&nbsp; 21056253 |
| Cooper Cos., Inc.<sup>(a)</sup> | 27416 | &nbsp;&nbsp; 1879641 |
| Dexcom, Inc.<sup>(a)</sup> | 38114 | &nbsp;&nbsp; 2564691 |
| Edwards Lifesciences Corp.<sup>(a)</sup> | 205137 | &nbsp;&nbsp; 15953505 |
| &nbsp;&nbsp;&nbsp; EXO Imaging, Inc., (Acquired 06/24/21, Cost: <br> $595,999)<sup>(a)(d)(e)</sup><br>| 1017 | &nbsp;&nbsp; 366 |
| GE HealthCare Technologies, Inc.<sup>(a)</sup> | 21440 | &nbsp;&nbsp; 1610144 |
| Glaukos Corp.<sup>(a)</sup> | 7815 | &nbsp;&nbsp; 637313 |
| Hologic, Inc.<sup>(a)</sup> | 12498 | &nbsp;&nbsp; 843490 |
| IDEXX Laboratories, Inc.<sup>(a)</sup> | 6922 | &nbsp;&nbsp; 4422397 |
| Inspire Medical Systems, Inc.<sup>(a)</sup> | 4705 | &nbsp;&nbsp; 349111 |
| Insulet Corp.<sup>(a)</sup> | 8004 | &nbsp;&nbsp; 2471075 |
| Intuitive Surgical, Inc.<sup>(a)</sup> | 30454 | &nbsp;&nbsp; 13619942 |
| Medtronic PLC | 187946 | &nbsp;&nbsp; 17899977 |
| Novocure Ltd.<sup>(a)</sup> | 51195 | &nbsp;&nbsp; 661439 |
| Nucleix Ltd., (Acquired 04/10/24, Cost: $200,000)<sup>(a)(d)(e)</sup> | 200 | &nbsp;&nbsp; 148540 |
| Nyxoah SA<sup>(a)(c)</sup> | 29870 | &nbsp;&nbsp; 137402 |
| Orchestra BioMed Holdings, Inc.<sup>(a)(c)</sup> | 18076 | &nbsp;&nbsp; 44829 |
| Penumbra, Inc.<sup>(a)</sup> | 11896 | &nbsp;&nbsp; 3013495 |
| STERIS PLC | 6027 | &nbsp;&nbsp; 1491321 |
| Stryker Corp. | 48820 | &nbsp;&nbsp; 18047289 |
|  |  | &nbsp;&nbsp; 145515340 |
| **Health Care Providers & Services — 13.2%** | **Health Care Providers & Services — 13.2%** |  |
| Cencora, Inc. | 26637 | &nbsp;&nbsp; 8324861 |
| Centene Corp.<sup>(a)</sup> | 49135 | &nbsp;&nbsp; 1753137 |
| Cigna Group | 9313 | &nbsp;&nbsp; 2684472 |
| CVS Health Corp. | 32565 | &nbsp;&nbsp; 2455075 |
| Elevance Health, Inc. | 7850 | &nbsp;&nbsp; 2536492 |
| Guardant Health, Inc.<sup>(a)</sup> | 31531 | &nbsp;&nbsp; 1970057 |
| HCA Healthcare, Inc. | 12565 | &nbsp;&nbsp; 5355203 |
| Labcorp Holdings, Inc. | 20462 | &nbsp;&nbsp; 5873822 |
| McKesson Corp. | 11805 | &nbsp;&nbsp; 9119835 |
| Quest Diagnostics, Inc. | 24219 | &nbsp;&nbsp; 4615657 |
| Tenet Healthcare Corp.<sup>(a)</sup> | 9500 | &nbsp;&nbsp; 1928880 |
| UnitedHealth Group, Inc.<sup>(b)</sup> | 63340 | &nbsp;&nbsp; 21871302 |
|  |  | &nbsp;&nbsp; 68488793 |
| **Health Care Technology**<sup>(a)</sup> **— 0.5%** | **Health Care Technology**<sup>(a)</sup> **— 0.5%** |  |
| &nbsp;&nbsp;&nbsp; Carbon Health Technologies, Inc., (Acquired 05/28/25, <br> Cost: $972,000)<sup>(d)(e)</sup><br>| 146332 | &nbsp;&nbsp; 1463 |
| HeartFlow, Inc. | 1890 | &nbsp;&nbsp; 63618 |
| Veeva Systems, Inc., Class A | 8920 | &nbsp;&nbsp; 2657357 |
|  |  | &nbsp;&nbsp; 2722438 |
| **Life Sciences Tools & Services — 9.3%** | **Life Sciences Tools & Services — 9.3%** |  |
| Agilent Technologies, Inc. | 37005 | &nbsp;&nbsp; 4749592 |
| Bio-Rad Laboratories, Inc., Class A<sup>(a)</sup> | 2236 | &nbsp;&nbsp; 626952 |
| Bio-Techne Corp. | 17518 | &nbsp;&nbsp; 974526 |
| Bruker Corp. | 44389 | &nbsp;&nbsp; 1442199 |
| Charles River Laboratories International, Inc.<sup>(a)</sup> | 5060 | &nbsp;&nbsp; 791688 |
| Danaher Corp. | 44278 | &nbsp;&nbsp; 8778556 |
| Illumina, Inc.<sup>(a)</sup> | 13625 | &nbsp;&nbsp; 1293966 |
| IQVIA Holdings, Inc.<sup>(a)</sup> | 16167 | &nbsp;&nbsp; 3070760 |
| Mettler-Toledo International, Inc.<sup>(a)</sup> | 635 | &nbsp;&nbsp; 779532 |
| Repligen Corp.<sup>(a)</sup> | 12836 | &nbsp;&nbsp; 1715788 |
| Thermo Fisher Scientific, Inc. | 37523 | &nbsp;&nbsp; 18199406 |
| Waters Corp.<sup>(a)</sup> | 10495 | &nbsp;&nbsp; 3146506 |
| West Pharmaceutical Services, Inc. | 10207 | &nbsp;&nbsp; 2677602 |
|  |  | &nbsp;&nbsp; 48247073 |
| **Pharmaceuticals — 22.5%** | **Pharmaceuticals — 22.5%** |  |
| AstraZeneca PLC | 32707 | &nbsp;&nbsp; 5010745 |
| Bristol-Myers Squibb Co. | 97755 | &nbsp;&nbsp; 4408751 |

---

------

Schedule of Investments (unaudited)(continued)

September 30, 2025

**BlackRock Health Sciences Trust (BME)** 

**(Percentages shown are based on Net Assets)**

---

| | | |
|:---|:---|:---|
| *Security* | <br> *Shares*<br>| *Value* |
| **Pharmaceuticals (continued)** | **Pharmaceuticals (continued)** |  |
| Daiichi Sankyo Co. Ltd. | 62300 | &nbsp;&nbsp; $1401762 |
| Edgewise Therapeutics, Inc.<sup>(a)</sup> | 22836 | &nbsp;&nbsp; 370400 |
| Elanco Animal Health, Inc.<sup>(a)</sup> | 42100 | &nbsp;&nbsp; 847894 |
| Eli Lilly & Co.<sup>(b)</sup> | 53254 | &nbsp;&nbsp; 40632802 |
| Galderma Group AG | 13599 | &nbsp;&nbsp; 2404306 |
| Johnson & Johnson | 230823 | &nbsp;&nbsp; 42799201 |
| LB Pharmaceuticals, Inc.<sup>(a)(c)</sup> | 48308 | &nbsp;&nbsp; 762783 |
| MBX Biosciences, Inc.<sup>(a)</sup> | 29168 | &nbsp;&nbsp; 510440 |
| Merck & Co., Inc.<sup>(b)</sup> | 88682 | &nbsp;&nbsp; 7443080 |
| Pfizer, Inc. | 106328 | &nbsp;&nbsp; 2709237 |
| Teva Pharmaceutical Industries Ltd., ADR<sup>(a)</sup> | 243163 | &nbsp;&nbsp; 4911893 |
| UCB SA | 10073 | &nbsp;&nbsp; 2811726 |
| WaVe Life Sciences Ltd.<sup>(a)</sup> | 24727 | &nbsp;&nbsp; 181002 |
|  |  | &nbsp;&nbsp; 117206022 |
| **Total Common Stocks — 99.3%** <br>**(Cost: $337,049,669)** | **Total Common Stocks — 99.3%** <br>**(Cost: $337,049,669)** | &nbsp;&nbsp; 516519310 |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

---

| | | |
|:---|:---|:---|
|  | *Benefical* <br>*Interest (000)*<br>|  |
| **Other Interests** | **Other Interests** | **Other Interests** |
| **Biotechnology — 0.0%** | **Biotechnology — 0.0%** |  |
| Affinivax, Inc., (Acquired 08/18/22, Cost: $—)<sup>(d)(e)(f)</sup> | $6 | &nbsp;&nbsp; 62677 |
| **Health Care Providers & Services — 0.0%** | **Health Care Providers & Services — 0.0%** |  |
| &nbsp;&nbsp;&nbsp; Afferent Pharmaceuticals, Inc., (Acquired 09/30/15, <br> Cost: $—)<sup>(d)(e)(f)</sup><br>| 190 | &nbsp;&nbsp; 2 |
| **Total Other Interests — 0.0%** <br>**(Cost: $—)** | **Total Other Interests — 0.0%** <br>**(Cost: $—)** | &nbsp;&nbsp; 62679 |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

---

| | | |
|:---|:---|:---|
|  | <br>*Shares*<br>|  |
| **Preferred Securities** | **Preferred Securities** | **Preferred Securities** |
| **Preferred Stocks — 0.6%**<sup>(a)(d)(e)</sup> | **Preferred Stocks — 0.6%**<sup>(a)(d)(e)</sup> | **Preferred Stocks — 0.6%**<sup>(a)(d)(e)</sup> |
| **Biotechnology — 0.4%** | **Biotechnology — 0.4%** |  |
| &nbsp;&nbsp;&nbsp; Adarx Pharamaceuticals, Inc., Series C, (Acquired <br> 08/02/23, Cost: $440,003)<br>| 52885 | &nbsp;&nbsp; 628803 |
| &nbsp;&nbsp;&nbsp; Cellarity, Inc., Series B, (Acquired 01/15/21, Cost: <br> $265,002)<br>| 44167 | &nbsp;&nbsp; 90542 |
| &nbsp;&nbsp;&nbsp; Genesis Therapeutics, Inc., Series B, (Acquired 08/10/23, <br> Cost: $292,001)<br>| 57170 | &nbsp;&nbsp; 316722 |
| &nbsp;&nbsp;&nbsp; Goldfinch Bio, Inc., Series B, (Acquired 06/26/20, Cost: <br> $224,200)<br>| 190000 | &nbsp;&nbsp; 76000 |
| Kartos Therapeutics, Inc. |  |  |
| &nbsp;&nbsp;&nbsp; Series C, (Acquired 08/22/23, Cost: $485,124) | 85817 | &nbsp;&nbsp; 487440 |
| &nbsp;&nbsp;&nbsp; Series D, (Acquired 02/19/25, Cost: $133,467) | 23610 | &nbsp;&nbsp; 134105 |
| &nbsp;&nbsp;&nbsp; Laronde, Inc., Series B, (Acquired 07/28/21, Cost: <br> $590,800)<br>| 21100 | &nbsp;&nbsp; 512730 |
|  |  | &nbsp;&nbsp; 2246342 |
| **Health Care Equipment & Supplies — 0.1%** | **Health Care Equipment & Supplies — 0.1%** |  |
| &nbsp;&nbsp;&nbsp; EXO Imaging, Inc., Series D, (Acquired 07/24/24, Cost: <br> $28,863)<br>| 47496 | &nbsp;&nbsp; 35147 |
| &nbsp;&nbsp;&nbsp; Nucleix Ltd., Series AA, (Acquired 03/25/21, Cost: <br> $1,070,001)<br>| 367395 | &nbsp;&nbsp; 224111 |

---

---

| | | |
|:---|:---|:---|
| *Security* | <br> *Shares*<br>| *Value* |
| **Health Care Equipment & Supplies (continued)** | **Health Care Equipment & Supplies (continued)** |  |
| &nbsp;&nbsp;&nbsp; Quanta Dialysis Technologies Ltd., Series D, (Acquired <br> 06/18/21, Cost: $515,759)<br>| 4243029 | &nbsp;&nbsp; $302442 |
| &nbsp;&nbsp;&nbsp; Swift Health Systems, Inc., Series D, (Acquired 08/27/21, <br> Cost: $286,998)<br>| 93 | &nbsp;&nbsp; 206 |
|  |  | &nbsp;&nbsp; 561906 |
| **Pharmaceuticals — 0.1%** | **Pharmaceuticals — 0.1%** |  |
| &nbsp;&nbsp;&nbsp; Insitro, Inc., Series C, (Acquired 03/10/21, Cost: <br> $560,000)<br>| 30616 | &nbsp;&nbsp; 280443 |
|  |  | &nbsp;&nbsp; 3088691 |
| **Total Preferred Securities — 0.6%** <br>**(Cost: $4,892,218)** | **Total Preferred Securities — 0.6%** <br>**(Cost: $4,892,218)** | &nbsp;&nbsp; 3088691 |
| **Rights** | **Rights** | **Rights** |
| **Biotechnology**<sup>(e)</sup> **— 0.0%** | **Biotechnology**<sup>(e)</sup> **— 0.0%** |  |
| Blueprint Medicines Corp., CVR | 15552 | &nbsp;&nbsp; 15085 |
| Korro Bio, Inc., CVR | 28060 | &nbsp;&nbsp; — |
| Mirati Therapeutics, Inc. CVR | 15747 | &nbsp;&nbsp; 12283 |
|  |  | &nbsp;&nbsp; 27368 |
| **Health Care Equipment & Supplies — 0.0%** | **Health Care Equipment & Supplies — 0.0%** |  |
| Abiomed, Inc., CVR<sup>(e)</sup> | 14359 | &nbsp;&nbsp; 32308 |
| **Total Rights — 0.0%** <br>**(Cost: $32,823)** | **Total Rights — 0.0%** <br>**(Cost: $32,823)** | &nbsp;&nbsp; 59676 |
| **Warrants** | **Warrants** | **Warrants** |
| **Pharmaceuticals — 0.0%** | **Pharmaceuticals — 0.0%** |  |
| &nbsp;&nbsp;&nbsp; Nuvation Bio, Inc., (Issued/Exercisable 08/17/20, 1 Share <br> for 1 Warrant, Expires 07/07/27, Strike Price USD <br> 11.50)<sup>(a)</sup><br>| 4050 | &nbsp;&nbsp; 818 |
| **Total Warrants — 0.0%** <br>**(Cost: $8,057)** | **Total Warrants — 0.0%** <br>**(Cost: $8,057)** | &nbsp;&nbsp; 818 |
| **Total Long-Term Investments — 99.9%** <br>**(Cost: $341,982,767)** | **Total Long-Term Investments — 99.9%** <br>**(Cost: $341,982,767)** | &nbsp;&nbsp; 519731174 |
| **Short-Term Securities** | **Short-Term Securities** | **Short-Term Securities** |
| **Money Market Funds — 1.6%** | **Money Market Funds — 1.6%** |  |
| &nbsp;&nbsp;&nbsp; BlackRock Cash Funds: Institutional, SL Agency Shares, <br> 4.26%<sup>(g)(h)(i)</sup><br>| 962199 | &nbsp;&nbsp; 962680 |
| &nbsp;&nbsp;&nbsp; BlackRock Liquidity Funds, T-Fund, Institutional Shares, <br> 4.01%<sup>(g)(h)</sup><br>| 7130620 | &nbsp;&nbsp; 7130620 |
| **Total Short-Term Securities — 1.6%** <br>**(Cost: $8,093,364)** | **Total Short-Term Securities — 1.6%** <br>**(Cost: $8,093,364)** | &nbsp;&nbsp; 8093300 |
| **Total Investments Before Options Written — 101.5%** <br>**(Cost: $350,076,131)** | **Total Investments Before Options Written — 101.5%** <br>**(Cost: $350,076,131)** | &nbsp;&nbsp; 527824474 |
| **Options Written — (1.3)%** <br>**(Premiums Received: $(4866731))** | **Options Written — (1.3)%** <br>**(Premiums Received: $(4866731))** | &nbsp;&nbsp; (6446061)<br>|
| **Total Investments, Net of Options Written — 100.2%** <br>**(Cost: $345,209,400)** | **Total Investments, Net of Options Written — 100.2%** <br>**(Cost: $345,209,400)** | &nbsp;&nbsp; 521378413 |
| **Liabilities in Excess of Other Assets — (0.2)%** | **Liabilities in Excess of Other Assets — (0.2)%** | &nbsp;&nbsp; (996276)<br>|
| **Net Assets — 100.0%** | **Net Assets — 100.0%** | &nbsp;&nbsp; $520382137 |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

<sup>(a)</sup> Non-income producing security.

<sup>(b)</sup> All or a portion of the security has been pledged and/or segregated as collateral in connection with outstanding exchange-traded options written. 

<sup>(c)</sup> All or a portion of this security is on loan.

Schedule of Investments

------

Schedule of Investments (unaudited)(continued)

September 30, 2025

**BlackRock Health Sciences Trust (BME)** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

<sup>(d)</sup> Restricted security as to resale, excluding 144A securities. The Trust held restricted securities with a current value of $3,482,179, representing 0.7% of its net assets as of period end, and an original cost of $6,827,217. 

<sup>(e)</sup> Security is valued using significant unobservable inputs and is classified as Level 3 in the fair value hierarchy. 

<sup>(f)</sup> Other interests represent beneficial interests in liquidation trusts and other reorganization or private entities. 

<sup>(g)</sup> Affiliate of the Trust.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

<sup>(h)</sup> Annualized 7-day yield as of period end. <br> <sup>(i)</sup> All or a portion of this security was purchased with the cash collateral from loaned securities.

For purposes of this report, industry and sector sub-classifications may differ from those utilized by the Trust for compliance purposes.

**Affiliates**

Investments in issuers considered to be affiliate(s) of the Trust during the period ended September 30, 2025 for purposes of Section 2(a)(3) of the Investment Company Act of 1940, as amended, were as follows:

---

| | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| *Affiliated Issuer* | *Value at* <br>*12/31/24*<br>| *Purchases* <br>*at Cost*<br>| *Proceeds* <br>*from Sales*<br>| *Net* <br>*Realized* <br>*Gain (Loss)*<br>| *Change in* <br>*Unrealized* <br>*Appreciation* <br>*(Depreciation)*<br>| *Value at* <br>*09/30/25*<br>| *Shares* <br>*Held at* <br>*09/30/25*<br>| *Income* | *Capital Gain* <br>*Distributions* <br>*from* <br>*Underlying* <br>*Funds*<br>|
| BlackRock Cash Funds: Institutional, SL Agency Shares | $277709 | $685380 <br><sup>(a)</sup><br>| &nbsp;&nbsp; $— | &nbsp;&nbsp; $(329)<br>| $(80)<br>| $962680 | 962199 | $7582 <br><sup>(b)</sup><br>| &nbsp;&nbsp; $— |
| BlackRock Liquidity Funds, T-Fund, Institutional Shares | 26275044 |  | &nbsp;&nbsp; (19144424 )<sup>(a)</sup><br>| &nbsp;&nbsp; — |  | 7130620 | 7130620 | 608395 | &nbsp;&nbsp; — |
|  |  |  |  | &nbsp;&nbsp; $(329)<br>| $(80)<br>| $8093300 |  | $615977 | &nbsp;&nbsp; $— |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

<sup>(a)</sup> Represents net amount purchased (sold).

<sup>(b)</sup> All or a portion represents securities lending income earned from the reinvestment of cash collateral from loaned securities, net of collateral investment fees, and other payments to and from borrowers of securities. 

**Derivative Financial Instruments Outstanding as of Period End**

**Exchange-Traded Options Written** 

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| *Description* | *Number of* <br>*Contracts*<br>| &nbsp;&nbsp; *Expiration* <br>*Date*<br>| *Exercise Price* | *Exercise Price* | &nbsp;&nbsp;&nbsp; *Notional* <br>*Amount (000)* | &nbsp;&nbsp;&nbsp; *Notional* <br>*Amount (000)* | *Value* |
| Call  |  |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp; Eli Lilly & Co. | &nbsp;&nbsp; 63 | &nbsp;&nbsp;&nbsp;&nbsp; 10/03/25 | USD | 740.00 | USD | 4807 | &nbsp;&nbsp;&nbsp;&nbsp; $(160807)<br>|
| &nbsp;&nbsp;&nbsp; Johnson & Johnson | &nbsp;&nbsp; 417 | &nbsp;&nbsp;&nbsp;&nbsp; 10/03/25 | USD | 180.00 | USD | 7732 | &nbsp;&nbsp;&nbsp;&nbsp; (237690)<br>|
| &nbsp;&nbsp;&nbsp; Teva Pharmaceutical Industries Ltd., ADR | &nbsp;&nbsp; 462 | &nbsp;&nbsp;&nbsp;&nbsp; 10/03/25 | USD | 19.50 | USD | 933 | &nbsp;&nbsp;&nbsp;&nbsp; (41811)<br>|
| &nbsp;&nbsp;&nbsp; Abbott Laboratories | &nbsp;&nbsp; 246 | &nbsp;&nbsp;&nbsp;&nbsp; 10/10/25 | USD | 136.00 | USD | 3295 | &nbsp;&nbsp;&nbsp;&nbsp; (27921)<br>|
| &nbsp;&nbsp;&nbsp; Boston Scientific Corp. | &nbsp;&nbsp; 290 | &nbsp;&nbsp;&nbsp;&nbsp; 10/10/25 | USD | 108.00 | USD | 2831 | &nbsp;&nbsp;&nbsp;&nbsp; (14500)<br>|
| &nbsp;&nbsp;&nbsp; Dexcom, Inc. | &nbsp;&nbsp; 42 | &nbsp;&nbsp;&nbsp;&nbsp; 10/10/25 | USD | 85.00 | USD | 283 | &nbsp;&nbsp;&nbsp;&nbsp; (2310)<br>|
| &nbsp;&nbsp;&nbsp; Medtronic PLC | &nbsp;&nbsp; 69 | &nbsp;&nbsp;&nbsp;&nbsp; 10/10/25 | USD | 94.00 | USD | 657 | &nbsp;&nbsp;&nbsp;&nbsp; (15353)<br>|
| &nbsp;&nbsp;&nbsp; Pfizer, Inc. | &nbsp;&nbsp; 106 | &nbsp;&nbsp;&nbsp;&nbsp; 10/10/25 | USD | 25.50 | USD | 270 | &nbsp;&nbsp;&nbsp;&nbsp; (5194)<br>|
| &nbsp;&nbsp;&nbsp; AbbVie, Inc. | &nbsp;&nbsp; 248 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 210.00 | USD | 5742 | &nbsp;&nbsp;&nbsp;&nbsp; (542500)<br>|
| &nbsp;&nbsp;&nbsp; Agilent Technologies, Inc. | &nbsp;&nbsp; 70 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 130.00 | USD | 898 | &nbsp;&nbsp;&nbsp;&nbsp; (19775)<br>|
| &nbsp;&nbsp;&nbsp; Agilent Technologies, Inc. | &nbsp;&nbsp; 70 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 135.00 | USD | 898 | &nbsp;&nbsp;&nbsp;&nbsp; (7350)<br>|
| &nbsp;&nbsp;&nbsp; Alcon AG | &nbsp;&nbsp; 22 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 80.00 | USD | 164 | &nbsp;&nbsp;&nbsp;&nbsp; (440)<br>|
| &nbsp;&nbsp;&nbsp; Alkermes PLC | &nbsp;&nbsp; 48 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 29.00 | USD | 144 | &nbsp;&nbsp;&nbsp;&nbsp; (8280)<br>|
| &nbsp;&nbsp;&nbsp; Alnylam Pharmaceuticals, Inc. | &nbsp;&nbsp; 50 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 470.00 | USD | 2280 | &nbsp;&nbsp;&nbsp;&nbsp; (41750)<br>|
| &nbsp;&nbsp;&nbsp; Alnylam Pharmaceuticals, Inc. | &nbsp;&nbsp; 68 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 490.00 | USD | 3101 | &nbsp;&nbsp;&nbsp;&nbsp; (21930)<br>|
| &nbsp;&nbsp;&nbsp; Arcellx, Inc. | &nbsp;&nbsp; 62 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 75.00 | USD | 509 | &nbsp;&nbsp;&nbsp;&nbsp; (50530)<br>|
| &nbsp;&nbsp;&nbsp; Argenx SE, ADR | &nbsp;&nbsp; 21 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 760.00 | USD | 1549 | &nbsp;&nbsp;&nbsp;&nbsp; (25725)<br>|
| &nbsp;&nbsp;&nbsp; Beam Therapeutics, Inc. | &nbsp;&nbsp; 26 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 19.96 | USD | 63 | &nbsp;&nbsp;&nbsp;&nbsp; (11785)<br>|
| &nbsp;&nbsp;&nbsp; Becton Dickinson & Co. | &nbsp;&nbsp; 146 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 195.00 | USD | 2733 | &nbsp;&nbsp;&nbsp;&nbsp; (18615)<br>|
| &nbsp;&nbsp;&nbsp; Biogen, Inc. | &nbsp;&nbsp; 74 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 150.00 | USD | 1037 | &nbsp;&nbsp;&nbsp;&nbsp; (9250)<br>|
| &nbsp;&nbsp;&nbsp; Biohaven Ltd. | &nbsp;&nbsp; 35 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 22.50 | USD | 53 | &nbsp;&nbsp;&nbsp;&nbsp; (2100)<br>|
| &nbsp;&nbsp;&nbsp; Biohaven Ltd. | &nbsp;&nbsp; 35 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 20.00 | USD | 53 | &nbsp;&nbsp;&nbsp;&nbsp; (3150)<br>|
| &nbsp;&nbsp;&nbsp; BioMarin Pharmaceutical, Inc. | &nbsp;&nbsp; 75 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 62.50 | USD | 406 | &nbsp;&nbsp;&nbsp;&nbsp; (938)<br>|
| &nbsp;&nbsp;&nbsp; BioMarin Pharmaceutical, Inc. | &nbsp;&nbsp; 40 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 57.50 | USD | 217 | &nbsp;&nbsp;&nbsp;&nbsp; (2900)<br>|
| &nbsp;&nbsp;&nbsp; BioNTech SE, ADR | &nbsp;&nbsp; 14 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 105.00 | USD | 138 | &nbsp;&nbsp;&nbsp;&nbsp; (1610)<br>|
| &nbsp;&nbsp;&nbsp; Boston Scientific Corp. | &nbsp;&nbsp; 140 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 105.00 | USD | 1367 | &nbsp;&nbsp;&nbsp;&nbsp; (2800)<br>|
| &nbsp;&nbsp;&nbsp; Bruker Corp. | &nbsp;&nbsp; 100 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 40.00 | USD | 325 | &nbsp;&nbsp;&nbsp;&nbsp; (1500)<br>|
| &nbsp;&nbsp;&nbsp; Bruker Corp. | &nbsp;&nbsp; 68 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 35.00 | USD | 221 | &nbsp;&nbsp;&nbsp;&nbsp; (5440)<br>|

---

------

Schedule of Investments (unaudited)(continued)

September 30, 2025

**BlackRock Health Sciences Trust (BME)** 

**Exchange-Traded Options Written (continued)**

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| *Description* | *Number of*<br> *Contracts*<br>| &nbsp;&nbsp; *Expiration*<br> *Date*<br>| *Exercise Price* | *Exercise Price* | &nbsp;&nbsp;&nbsp; *Notional*<br> *Amount (000)* | &nbsp;&nbsp;&nbsp; *Notional*<br> *Amount (000)* | *Value* |
| Call (continued) |  |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp; Cooper Cos., Inc. | &nbsp;&nbsp; 104 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 70.00 | USD | 713 | &nbsp;&nbsp;&nbsp;&nbsp; $(14040)<br>|
| &nbsp;&nbsp;&nbsp; CVS Health Corp. | &nbsp;&nbsp; 22 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 75.00 | USD | 166 | &nbsp;&nbsp;&nbsp;&nbsp; (5841)<br>|
| &nbsp;&nbsp;&nbsp; Danaher Corp. | &nbsp;&nbsp; 60 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 200.00 | USD | 1190 | &nbsp;&nbsp;&nbsp;&nbsp; (30600)<br>|
| &nbsp;&nbsp;&nbsp; Denali Therapeutics, Inc. | &nbsp;&nbsp; 77 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 14.19 | USD | 112 | &nbsp;&nbsp;&nbsp;&nbsp; (6394)<br>|
| &nbsp;&nbsp;&nbsp; Edwards Lifesciences Corp. | &nbsp;&nbsp; 394 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 77.50 | USD | 3064 | &nbsp;&nbsp;&nbsp;&nbsp; (70920)<br>|
| &nbsp;&nbsp;&nbsp; Elevance Health, Inc. | &nbsp;&nbsp; 32 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 340.00 | USD | 1034 | &nbsp;&nbsp;&nbsp;&nbsp; (16000)<br>|
| &nbsp;&nbsp;&nbsp; Elevance Health, Inc. | &nbsp;&nbsp; 16 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 360.00 | USD | 517 | &nbsp;&nbsp;&nbsp;&nbsp; (2720)<br>|
| &nbsp;&nbsp;&nbsp; Exact Sciences Corp. | &nbsp;&nbsp; 56 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 52.50 | USD | 306 | &nbsp;&nbsp;&nbsp;&nbsp; (20160)<br>|
| &nbsp;&nbsp;&nbsp; Exelixis, Inc. | &nbsp;&nbsp; 103 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 41.00 | USD | 425 | &nbsp;&nbsp;&nbsp;&nbsp; (13133)<br>|
| &nbsp;&nbsp;&nbsp; GE HealthCare Technologies, Inc. | &nbsp;&nbsp; 43 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 75.00 | USD | 323 | &nbsp;&nbsp;&nbsp;&nbsp; (9138)<br>|
| &nbsp;&nbsp;&nbsp; Glaukos Corp. | &nbsp;&nbsp; 29 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 90.00 | USD | 236 | &nbsp;&nbsp;&nbsp;&nbsp; (1885)<br>|
| &nbsp;&nbsp;&nbsp; Guardant Health, Inc. | &nbsp;&nbsp; 71 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 60.00 | USD | 444 | &nbsp;&nbsp;&nbsp;&nbsp; (31240)<br>|
| &nbsp;&nbsp;&nbsp; HCA Healthcare, Inc. | &nbsp;&nbsp; 47 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 405.00 | USD | 2003 | &nbsp;&nbsp;&nbsp;&nbsp; (119145)<br>|
| &nbsp;&nbsp;&nbsp; Illumina, Inc. | &nbsp;&nbsp; 51 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 105.00 | USD | 484 | &nbsp;&nbsp;&nbsp;&nbsp; (3953)<br>|
| &nbsp;&nbsp;&nbsp; Incyte Corp. | &nbsp;&nbsp; 69 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 90.00 | USD | 585 | &nbsp;&nbsp;&nbsp;&nbsp; (5003)<br>|
| &nbsp;&nbsp;&nbsp; Insmed, Inc. | &nbsp;&nbsp; 86 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 125.00 | USD | 1238 | &nbsp;&nbsp;&nbsp;&nbsp; (179310)<br>|
| &nbsp;&nbsp;&nbsp; Insmed, Inc. | &nbsp;&nbsp; 113 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 150.00 | USD | 1627 | &nbsp;&nbsp;&nbsp;&nbsp; (32487)<br>|
| &nbsp;&nbsp;&nbsp; Inspire Medical Systems, Inc. | &nbsp;&nbsp; 17 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 90.00 | USD | 126 | &nbsp;&nbsp;&nbsp;&nbsp; (935)<br>|
| &nbsp;&nbsp;&nbsp; Insulet Corp. | &nbsp;&nbsp; 30 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 350.00 | USD | 926 | &nbsp;&nbsp;&nbsp;&nbsp; (10500)<br>|
| &nbsp;&nbsp;&nbsp; Intuitive Surgical, Inc. | &nbsp;&nbsp; 115 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 465.00 | USD | 5143 | &nbsp;&nbsp;&nbsp;&nbsp; (65550)<br>|
| &nbsp;&nbsp;&nbsp; Ionis Pharmaceuticals, Inc. | &nbsp;&nbsp; 58 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 65.01 | USD | 379 | &nbsp;&nbsp;&nbsp;&nbsp; (22623)<br>|
| &nbsp;&nbsp;&nbsp; IQVIA Holdings, Inc. | &nbsp;&nbsp; 61 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 195.00 | USD | 1159 | &nbsp;&nbsp;&nbsp;&nbsp; (18758)<br>|
| &nbsp;&nbsp;&nbsp; Johnson & Johnson | &nbsp;&nbsp; 460 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 180.00 | USD | 8529 | &nbsp;&nbsp;&nbsp;&nbsp; (324300)<br>|
| &nbsp;&nbsp;&nbsp; Kymera Therapeutics, Inc. | &nbsp;&nbsp; 18 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 55.00 | USD | 102 | &nbsp;&nbsp;&nbsp;&nbsp; (7830)<br>|
| &nbsp;&nbsp;&nbsp; Labcorp Holdings, Inc. | &nbsp;&nbsp; 67 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 270.00 | USD | 1923 | &nbsp;&nbsp;&nbsp;&nbsp; (124620)<br>|
| &nbsp;&nbsp;&nbsp; Labcorp Holdings, Inc. | &nbsp;&nbsp; 5 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 290.00 | USD | 144 | &nbsp;&nbsp;&nbsp;&nbsp; (1950)<br>|
| &nbsp;&nbsp;&nbsp; Medtronic PLC | &nbsp;&nbsp; 99 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 95.00 | USD | 943 | &nbsp;&nbsp;&nbsp;&nbsp; (17919)<br>|
| &nbsp;&nbsp;&nbsp; Mettler-Toledo International, Inc. | &nbsp;&nbsp; 2 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 1360.00 | USD | 246 | &nbsp;&nbsp;&nbsp;&nbsp; (960)<br>|
| &nbsp;&nbsp;&nbsp; Mettler-Toledo International, Inc. | &nbsp;&nbsp; 2 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 1310.00 | USD | 246 | &nbsp;&nbsp;&nbsp;&nbsp; (955)<br>|
| &nbsp;&nbsp;&nbsp; Moderna, Inc. | &nbsp;&nbsp; 123 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 26.00 | USD | 318 | &nbsp;&nbsp;&nbsp;&nbsp; (20295)<br>|
| &nbsp;&nbsp;&nbsp; Natera, Inc. | &nbsp;&nbsp; 43 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 170.00 | USD | 692 | &nbsp;&nbsp;&nbsp;&nbsp; (10965)<br>|
| &nbsp;&nbsp;&nbsp; Neurocrine Biosciences, Inc. | &nbsp;&nbsp; 19 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 135.00 | USD | 267 | &nbsp;&nbsp;&nbsp;&nbsp; (13870)<br>|
| &nbsp;&nbsp;&nbsp; Neurocrine Biosciences, Inc. | &nbsp;&nbsp; 24 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 150.00 | USD | 337 | &nbsp;&nbsp;&nbsp;&nbsp; (1800)<br>|
| &nbsp;&nbsp;&nbsp; Novocure Ltd. | &nbsp;&nbsp; 194 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 15.00 | USD | 251 | &nbsp;&nbsp;&nbsp;&nbsp; (3395)<br>|
| &nbsp;&nbsp;&nbsp; Protagonist Therapeutics, Inc. | &nbsp;&nbsp; 43 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 60.00 | USD | 286 | &nbsp;&nbsp;&nbsp;&nbsp; (32250)<br>|
| &nbsp;&nbsp;&nbsp; PTC Therapeutics, Inc. | &nbsp;&nbsp; 83 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 65.00 | USD | 509 | &nbsp;&nbsp;&nbsp;&nbsp; (10168)<br>|
| &nbsp;&nbsp;&nbsp; Regeneron Pharmaceuticals, Inc. | &nbsp;&nbsp; 16 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 615.00 | USD | 900 | &nbsp;&nbsp;&nbsp;&nbsp; (4080)<br>|
| &nbsp;&nbsp;&nbsp; Repligen Corp. | &nbsp;&nbsp; 36 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 135.00 | USD | 481 | &nbsp;&nbsp;&nbsp;&nbsp; (16380)<br>|
| &nbsp;&nbsp;&nbsp; Rhythm Pharmaceuticals, Inc. | &nbsp;&nbsp; 103 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 95.00 | USD | 1040 | &nbsp;&nbsp;&nbsp;&nbsp; (88580)<br>|
| &nbsp;&nbsp;&nbsp; Rhythm Pharmaceuticals, Inc. | &nbsp;&nbsp; 106 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 105.00 | USD | 1070 | &nbsp;&nbsp;&nbsp;&nbsp; (28090)<br>|
| &nbsp;&nbsp;&nbsp; Scholar Rock Holding Corp. | &nbsp;&nbsp; 29 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 40.00 | USD | 108 | &nbsp;&nbsp;&nbsp;&nbsp; (3770)<br>|
| &nbsp;&nbsp;&nbsp; STERIS PLC | &nbsp;&nbsp; 4 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 260.00 | USD | 99 | &nbsp;&nbsp;&nbsp;&nbsp; (620)<br>|
| &nbsp;&nbsp;&nbsp; Stoke Therapeutics, Inc. | &nbsp;&nbsp; 263 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 25.00 | USD | 618 | &nbsp;&nbsp;&nbsp;&nbsp; (26300)<br>|
| &nbsp;&nbsp;&nbsp; Stryker Corp. | &nbsp;&nbsp; 185 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 390.00 | USD | 6839 | &nbsp;&nbsp;&nbsp;&nbsp; (23125)<br>|
| &nbsp;&nbsp;&nbsp; Summit Therapeutics, Inc. | &nbsp;&nbsp; 69 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 21.00 | USD | 143 | &nbsp;&nbsp;&nbsp;&nbsp; (8280)<br>|
| &nbsp;&nbsp;&nbsp; Thermo Fisher Scientific, Inc. | &nbsp;&nbsp; 44 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 500.00 | USD | 2134 | &nbsp;&nbsp;&nbsp;&nbsp; (35200)<br>|
| &nbsp;&nbsp;&nbsp; United Therapeutics Corp. | &nbsp;&nbsp; 15 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 410.00 | USD | 629 | &nbsp;&nbsp;&nbsp;&nbsp; (22650)<br>|
| &nbsp;&nbsp;&nbsp; UnitedHealth Group, Inc. | &nbsp;&nbsp; 227 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 360.00 | USD | 7838 | &nbsp;&nbsp;&nbsp;&nbsp; (125985)<br>|
| &nbsp;&nbsp;&nbsp; Veeva Systems, Inc., Class A | &nbsp;&nbsp; 33 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 280.00 | USD | 983 | &nbsp;&nbsp;&nbsp;&nbsp; (69300)<br>|
| &nbsp;&nbsp;&nbsp; Vertex Pharmaceuticals, Inc. | &nbsp;&nbsp; 24 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 430.00 | USD | 940 | &nbsp;&nbsp;&nbsp;&nbsp; (1740)<br>|
| &nbsp;&nbsp;&nbsp; Vertex Pharmaceuticals, Inc. | &nbsp;&nbsp; 24 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 397.50 | USD | 940 | &nbsp;&nbsp;&nbsp;&nbsp; (17040)<br>|
| &nbsp;&nbsp;&nbsp; Waters Corp. | &nbsp;&nbsp; 48 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 310.00 | USD | 1439 | &nbsp;&nbsp;&nbsp;&nbsp; (19320)<br>|
| &nbsp;&nbsp;&nbsp; WaVe Life Sciences Ltd. | &nbsp;&nbsp; 55 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 8.50 | USD | 40 | &nbsp;&nbsp;&nbsp;&nbsp; (1055)<br>|
| &nbsp;&nbsp;&nbsp; WaVe Life Sciences Ltd. | &nbsp;&nbsp; 38 | &nbsp;&nbsp;&nbsp;&nbsp; 10/17/25 | USD | 7.50 | USD | 28 | &nbsp;&nbsp;&nbsp;&nbsp; (2660)<br>|
| &nbsp;&nbsp;&nbsp; Abbott Laboratories | &nbsp;&nbsp; 220 | &nbsp;&nbsp;&nbsp;&nbsp; 10/24/25 | USD | 138.00 | USD | 2947 | &nbsp;&nbsp;&nbsp;&nbsp; (45540)<br>|
| &nbsp;&nbsp;&nbsp; Amgen, Inc. | &nbsp;&nbsp; 99 | &nbsp;&nbsp;&nbsp;&nbsp; 10/24/25 | USD | 290.00 | USD | 2794 | &nbsp;&nbsp;&nbsp;&nbsp; (41085)<br>|
| &nbsp;&nbsp;&nbsp; Biogen, Inc. | &nbsp;&nbsp; 36 | &nbsp;&nbsp;&nbsp;&nbsp; 10/24/25 | USD | 149.00 | USD | 504 | &nbsp;&nbsp;&nbsp;&nbsp; (7020)<br>|
| &nbsp;&nbsp;&nbsp; Boston Scientific Corp. | &nbsp;&nbsp; 281 | &nbsp;&nbsp;&nbsp;&nbsp; 10/24/25 | USD | 106.00 | USD | 2743 | &nbsp;&nbsp;&nbsp;&nbsp; (20372)<br>|
| &nbsp;&nbsp;&nbsp; CVS Health Corp. | &nbsp;&nbsp; 101 | &nbsp;&nbsp;&nbsp;&nbsp; 10/24/25 | USD | 77.00 | USD | 761 | &nbsp;&nbsp;&nbsp;&nbsp; (19392)<br>|
| &nbsp;&nbsp;&nbsp; GE HealthCare Technologies, Inc. | &nbsp;&nbsp; 38 | &nbsp;&nbsp;&nbsp;&nbsp; 10/24/25 | USD | 77.00 | USD | 285 | &nbsp;&nbsp;&nbsp;&nbsp; (5890)<br>|
| &nbsp;&nbsp;&nbsp; Medtronic PLC | &nbsp;&nbsp; 222 | &nbsp;&nbsp;&nbsp;&nbsp; 10/24/25 | USD | 96.00 | USD | 2114 | &nbsp;&nbsp;&nbsp;&nbsp; (36852)<br>|
| &nbsp;&nbsp;&nbsp; Merck & Co., Inc. | &nbsp;&nbsp; 60 | &nbsp;&nbsp;&nbsp;&nbsp; 10/24/25 | USD | 87.00 | USD | 504 | &nbsp;&nbsp;&nbsp;&nbsp; (7920)<br>|

---

Schedule of Investments

------

Schedule of Investments (unaudited)(continued)

September 30, 2025

**BlackRock Health Sciences Trust (BME)** 

**Exchange-Traded Options Written (continued)**

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| *Description* | *Number of*<br> *Contracts*<br>| &nbsp;&nbsp; *Expiration*<br> *Date*<br>| *Exercise Price* | *Exercise Price* | &nbsp;&nbsp;&nbsp; *Notional*<br> *Amount (000)* | &nbsp;&nbsp;&nbsp; *Notional*<br> *Amount (000)* | *Value* |
| Call (continued) |  |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp; Merck & Co., Inc. | &nbsp;&nbsp; 276 | &nbsp;&nbsp;&nbsp;&nbsp; 10/24/25 | USD | 81.00 | USD | 2316 | &nbsp;&nbsp;&nbsp;&nbsp; $(120750)<br>|
| &nbsp;&nbsp;&nbsp; Pfizer, Inc. | &nbsp;&nbsp; 105 | &nbsp;&nbsp;&nbsp;&nbsp; 10/24/25 | USD | 25.00 | USD | 268 | &nbsp;&nbsp;&nbsp;&nbsp; (10290)<br>|
| &nbsp;&nbsp;&nbsp; Regeneron Pharmaceuticals, Inc. | &nbsp;&nbsp; 17 | &nbsp;&nbsp;&nbsp;&nbsp; 10/24/25 | USD | 620.00 | USD | 956 | &nbsp;&nbsp;&nbsp;&nbsp; (7905)<br>|
| &nbsp;&nbsp;&nbsp; Teva Pharmaceutical Industries Ltd., ADR | &nbsp;&nbsp; 462 | &nbsp;&nbsp;&nbsp;&nbsp; 10/24/25 | USD | 20.50 | USD | 933 | &nbsp;&nbsp;&nbsp;&nbsp; (35574)<br>|
| &nbsp;&nbsp;&nbsp; Abbott Laboratories | &nbsp;&nbsp; 413 | &nbsp;&nbsp;&nbsp;&nbsp; 10/31/25 | USD | 134.00 | USD | 5532 | &nbsp;&nbsp;&nbsp;&nbsp; (162102)<br>|
| &nbsp;&nbsp;&nbsp; AbbVie, Inc. | &nbsp;&nbsp; 156 | &nbsp;&nbsp;&nbsp;&nbsp; 10/31/25 | USD | 230.00 | USD | 3612 | &nbsp;&nbsp;&nbsp;&nbsp; (109590)<br>|
| &nbsp;&nbsp;&nbsp; Danaher Corp. | &nbsp;&nbsp; 108 | &nbsp;&nbsp;&nbsp;&nbsp; 10/31/25 | USD | 200.00 | USD | 2141 | &nbsp;&nbsp;&nbsp;&nbsp; (96120)<br>|
| &nbsp;&nbsp;&nbsp; Eli Lilly & Co. | &nbsp;&nbsp; 81 | &nbsp;&nbsp;&nbsp;&nbsp; 10/31/25 | USD | 775.00 | USD | 6180 | &nbsp;&nbsp;&nbsp;&nbsp; (262440)<br>|
| &nbsp;&nbsp;&nbsp; Exact Sciences Corp. | &nbsp;&nbsp; 132 | &nbsp;&nbsp;&nbsp;&nbsp; 10/31/25 | USD | 54.00 | USD | 722 | &nbsp;&nbsp;&nbsp;&nbsp; (45540)<br>|
| &nbsp;&nbsp;&nbsp; Gilead Sciences, Inc. | &nbsp;&nbsp; 341 | &nbsp;&nbsp;&nbsp;&nbsp; 10/31/25 | USD | 116.00 | USD | 3785 | &nbsp;&nbsp;&nbsp;&nbsp; (81328)<br>|
| &nbsp;&nbsp;&nbsp; McKesson Corp. | &nbsp;&nbsp; 44 | &nbsp;&nbsp;&nbsp;&nbsp; 10/31/25 | USD | 710.00 | USD | 3399 | &nbsp;&nbsp;&nbsp;&nbsp; (302500)<br>|
| &nbsp;&nbsp;&nbsp; Pfizer, Inc. | &nbsp;&nbsp; 385 | &nbsp;&nbsp;&nbsp;&nbsp; 10/31/25 | USD | 25.50 | USD | 981 | &nbsp;&nbsp;&nbsp;&nbsp; (30415)<br>|
| &nbsp;&nbsp;&nbsp; Viking Therapeutics, Inc. | &nbsp;&nbsp; 36 | &nbsp;&nbsp;&nbsp;&nbsp; 10/31/25 | USD | 30.00 | USD | 95 | &nbsp;&nbsp;&nbsp;&nbsp; (4860)<br>|
| &nbsp;&nbsp;&nbsp; Cencora, Inc. | &nbsp;&nbsp; 39 | &nbsp;&nbsp;&nbsp;&nbsp; 11/04/25 | USD | 301.00 | USD | 1219 | &nbsp;&nbsp;&nbsp;&nbsp; (79854)<br>|
| &nbsp;&nbsp;&nbsp; Charles River Laboratories International, Inc. | &nbsp;&nbsp; 19 | &nbsp;&nbsp;&nbsp;&nbsp; 11/04/25 | USD | 162.00 | USD | 297 | &nbsp;&nbsp;&nbsp;&nbsp; (12086)<br>|
| &nbsp;&nbsp;&nbsp; Amgen, Inc. | &nbsp;&nbsp; 127 | &nbsp;&nbsp;&nbsp;&nbsp; 11/07/25 | USD | 285.00 | USD | 3584 | &nbsp;&nbsp;&nbsp;&nbsp; (125095)<br>|
| &nbsp;&nbsp;&nbsp; Bridgebio Pharma, Inc. | &nbsp;&nbsp; 70 | &nbsp;&nbsp;&nbsp;&nbsp; 11/07/25 | USD | 55.00 | USD | 364 | &nbsp;&nbsp;&nbsp;&nbsp; (23881)<br>|
| &nbsp;&nbsp;&nbsp; Bristol-Myers Squibb Co. | &nbsp;&nbsp; 372 | &nbsp;&nbsp;&nbsp;&nbsp; 11/07/25 | USD | 45.00 | USD | 1678 | &nbsp;&nbsp;&nbsp;&nbsp; (53010)<br>|
| &nbsp;&nbsp;&nbsp; Dexcom, Inc. | &nbsp;&nbsp; 102 | &nbsp;&nbsp;&nbsp;&nbsp; 11/07/25 | USD | 77.00 | USD | 686 | &nbsp;&nbsp;&nbsp;&nbsp; (16320)<br>|
| &nbsp;&nbsp;&nbsp; Disc Medicine, Inc. | &nbsp;&nbsp; 29 | &nbsp;&nbsp;&nbsp;&nbsp; 11/07/25 | USD | 65.00 | USD | 192 | &nbsp;&nbsp;&nbsp;&nbsp; (15521)<br>|
| &nbsp;&nbsp;&nbsp; Eli Lilly & Co. | &nbsp;&nbsp; 58 | &nbsp;&nbsp;&nbsp;&nbsp; 11/07/25 | USD | 760.00 | USD | 4425 | &nbsp;&nbsp;&nbsp;&nbsp; (242585)<br>|
| &nbsp;&nbsp;&nbsp; Incyte Corp. | &nbsp;&nbsp; 55 | &nbsp;&nbsp;&nbsp;&nbsp; 11/07/25 | USD | 86.25 | USD | 466 | &nbsp;&nbsp;&nbsp;&nbsp; (19372)<br>|
| &nbsp;&nbsp;&nbsp; Medtronic PLC | &nbsp;&nbsp; 324 | &nbsp;&nbsp;&nbsp;&nbsp; 11/07/25 | USD | 95.00 | USD | 3086 | &nbsp;&nbsp;&nbsp;&nbsp; (91368)<br>|
| &nbsp;&nbsp;&nbsp; Protagonist Therapeutics, Inc. | &nbsp;&nbsp; 81 | &nbsp;&nbsp;&nbsp;&nbsp; 11/07/25 | USD | 65.86 | USD | 538 | &nbsp;&nbsp;&nbsp;&nbsp; (45895)<br>|
| &nbsp;&nbsp;&nbsp; Repligen Corp. | &nbsp;&nbsp; 12 | &nbsp;&nbsp;&nbsp;&nbsp; 11/07/25 | USD | 130.00 | USD | 160 | &nbsp;&nbsp;&nbsp;&nbsp; (12669)<br>|
| &nbsp;&nbsp;&nbsp; STERIS PLC | &nbsp;&nbsp; 18 | &nbsp;&nbsp;&nbsp;&nbsp; 11/07/25 | USD | 252.10 | USD | 445 | &nbsp;&nbsp;&nbsp;&nbsp; (11071)<br>|
| &nbsp;&nbsp;&nbsp; IDEXX Laboratories, Inc. | &nbsp;&nbsp; 26 | &nbsp;&nbsp;&nbsp;&nbsp; 11/10/25 | USD | 643.00 | USD | 1661 | &nbsp;&nbsp;&nbsp;&nbsp; (78874)<br>|
| &nbsp;&nbsp;&nbsp; Boston Scientific Corp. | &nbsp;&nbsp; 163 | &nbsp;&nbsp;&nbsp;&nbsp; 11/21/25 | USD | 110.00 | USD | 1591 | &nbsp;&nbsp;&nbsp;&nbsp; (10595)<br>|
| &nbsp;&nbsp;&nbsp; Edwards Lifesciences Corp. | &nbsp;&nbsp; 385 | &nbsp;&nbsp;&nbsp;&nbsp; 11/21/25 | USD | 80.00 | USD | 2994 | &nbsp;&nbsp;&nbsp;&nbsp; (116462)<br>|
| &nbsp;&nbsp;&nbsp; Guardant Health, Inc. | &nbsp;&nbsp; 48 | &nbsp;&nbsp;&nbsp;&nbsp; 11/21/25 | USD | 60.00 | USD | 300 | &nbsp;&nbsp;&nbsp;&nbsp; (34320)<br>|
| &nbsp;&nbsp;&nbsp; Labcorp Holdings, Inc. | &nbsp;&nbsp; 5 | &nbsp;&nbsp;&nbsp;&nbsp; 11/21/25 | USD | 280.00 | USD | 144 | &nbsp;&nbsp;&nbsp;&nbsp; (7550)<br>|
|  |  |  |  |  |  |  | &nbsp;&nbsp;&nbsp;&nbsp; $(5479754)<br>|

---

**OTC Options Written** 

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| *Description* | *Counterparty* | &nbsp;&nbsp; *Number of* <br>*Contracts*<br>| &nbsp;&nbsp; *Expiration* <br>*Date*<br>| *Exercise Price* | *Exercise Price* | *Notional* <br>*Amount (000)* | *Notional* <br>*Amount (000)* | *Value* |
| Call  |  |  |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp; Cencora, Inc. | Barclays Bank PLC | 6200 | 10/01/25 | USD | 303.98 | &nbsp;&nbsp; USD | 1938 | &nbsp;&nbsp; $(53501)<br>|
| &nbsp;&nbsp;&nbsp; Zealand Pharma A/S | Bank of America N.A. | 2700 | 10/09/25 | DKK | 354.79 | &nbsp;&nbsp; DKK | 1266 | &nbsp;&nbsp; (45208)<br>|
| &nbsp;&nbsp;&nbsp; Galderma Group AG | Goldman Sachs International | 3900 | 10/16/25 | CHF | 141.68 | &nbsp;&nbsp; CHF | 549 | &nbsp;&nbsp; (8666)<br>|
| &nbsp;&nbsp;&nbsp; UCB SA | Bank of America N.A. | 3800 | 10/21/25 | EUR | 215.37 | &nbsp;&nbsp; EUR | 903 | &nbsp;&nbsp; (95519)<br>|
| &nbsp;&nbsp;&nbsp; Galderma Group AG | UBS AG | 1200 | 10/22/25 | CHF | 148.09 | &nbsp;&nbsp; CHF | 169 | &nbsp;&nbsp; (1974)<br>|
| &nbsp;&nbsp;&nbsp; AstraZeneca PLC | Barclays Bank PLC | 9100 | 10/28/25 | GBP | 115.28 | &nbsp;&nbsp; GBP | 1037 | &nbsp;&nbsp; (22673)<br>|
| &nbsp;&nbsp;&nbsp; AstraZeneca PLC | Bank of America N.A. | 3300 | 11/04/25 | GBP | 114.83 | &nbsp;&nbsp; GBP | 376 | &nbsp;&nbsp; (10668)<br>|
| &nbsp;&nbsp;&nbsp; Daiichi Sankyo Co. Ltd. | UBS AG | 23600 | 11/05/25 | JPY | 3561.94 | &nbsp;&nbsp; JPY | 78528 | &nbsp;&nbsp; (7782)<br>|
| &nbsp;&nbsp;&nbsp; Beam Therapeutics, Inc. | Morgan Stanley & Co. International PLC | 3000 | 11/06/25 | USD | 26.29 | &nbsp;&nbsp; USD | 73 | &nbsp;&nbsp; (4564)<br>|
| &nbsp;&nbsp;&nbsp; Penumbra, Inc. | Morgan Stanley & Co. International PLC | 4500 | 11/06/25 | USD | 261.88 | &nbsp;&nbsp; USD | 1140 | &nbsp;&nbsp; (48205)<br>|
| &nbsp;&nbsp;&nbsp; Ascendis Pharma A/S, ADR | Barclays Bank PLC | 3700 | 11/07/25 | USD | 204.97 | &nbsp;&nbsp; USD | 736 | &nbsp;&nbsp; (33218)<br>|
| &nbsp;&nbsp;&nbsp; Bio-Techne Corp. | BNP Paribas SA | 6600 | 11/07/25 | USD | 55.83 | &nbsp;&nbsp; USD | 367 | &nbsp;&nbsp; (21297)<br>|
| &nbsp;&nbsp;&nbsp; Merus NV | Morgan Stanley & Co. International PLC | 7000 | 11/07/25 | USD | 69.28 | &nbsp;&nbsp; USD | 659 | &nbsp;&nbsp; (176380)<br>|
| &nbsp;&nbsp;&nbsp; Natera, Inc. | Morgan Stanley & Co. International PLC | 300 | 11/07/25 | USD | 179.01 | &nbsp;&nbsp; USD | 48 | &nbsp;&nbsp; (1321)<br>|
| &nbsp;&nbsp;&nbsp; Nuvalent, Inc., Class A | Morgan Stanley & Co. International PLC | 11100 | 11/07/25 | USD | 80.43 | &nbsp;&nbsp; USD | 960 | &nbsp;&nbsp; (130649)<br>|
| &nbsp;&nbsp;&nbsp; Quest Diagnostics, Inc. | Barclays Bank PLC | 9200 | 11/07/25 | USD | 190.24 | &nbsp;&nbsp; USD | 1753 | &nbsp;&nbsp; (56233)<br>|
| &nbsp;&nbsp;&nbsp; Thermo Fisher Scientific, Inc. | Bank of America N.A. | 9800 | 11/07/25 | USD | 490.78 | &nbsp;&nbsp; USD | 4753 | &nbsp;&nbsp; (186436)<br>|
| &nbsp;&nbsp;&nbsp; West Pharmaceutical Services, Inc. | Barclays Bank PLC | 3800 | 11/07/25 | USD | 260.59 | &nbsp;&nbsp; USD | 997 | &nbsp;&nbsp; (62013)<br>|
|  |  |  |  |  |  |  |  | &nbsp;&nbsp; $(966307)<br>|

---

------

Schedule of Investments (unaudited)(continued)

September 30, 2025

**BlackRock Health Sciences Trust (BME)** 

**Fair Value Hierarchy as of Period End**

Various inputs are used in determining the fair value of financial instruments at the measurement date. These inputs to valuation techniques are categorized into a fair value hierarchy consisting of three broad levels for financial reporting purposes as follows:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Level 1 – Unadjusted price quotations in active markets/exchanges that the Trust has the ability to access for identical assets or liabilities;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Level 2 – Inputs other than quoted prices included within Level 1 that are observable for the asset or liability, either directly or indirectly; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Level 3 – Inputs that are unobservable and significant to the entire fair value measurement for the asset or liability (including the Valuation Committee's assumptions used in determining the fair value of financial instruments).

The hierarchy gives the highest priority to unadjusted quoted prices in active markets for identical assets or liabilities (Level 1 measurements) and the lowest priority to unobservable inputs (Level 3 measurements). Accordingly, the degree of judgment exercised in determining fair value is greatest for instruments categorized in Level 3. The inputs used to measure fair value may fall into different levels of the fair value hierarchy. In such cases, for disclosure purposes, the fair value hierarchy classification is determined based on the lowest level input that is significant to the fair value measurement in its entirety. Investments classified within Level 3 have significant unobservable inputs used by the Valuation Committee in determining the price for Fair Valued Investments. Level 3 investments include equity or debt issued by privately held companies or funds that may not have a secondary market and/or may have a limited number of investors. The categorization of a value determined for financial instruments is based on the pricing transparency of the financial instruments and is not necessarily an indication of the risks associated with investing in those securities. For information about the Trust's policy regarding valuation of financial instruments, refer to its most recent financial statements.

The following table summarizes the Trust's financial instruments categorized in the fair value hierarchy. The breakdown of the Trust's financial instruments into major categories is disclosed in the Schedule of Investments above.

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | *Level 1* | *Level 2* | *Level 3* | *Total* |
| Assets |  |  |  |  |
| &nbsp;&nbsp;&nbsp; Investments  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Long-Term Investments  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Common Stocks  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Biotechnology | &nbsp;&nbsp; $133615924 | &nbsp;&nbsp;&nbsp;&nbsp; $723720 | &nbsp;&nbsp;&nbsp;&nbsp; $— | &nbsp;&nbsp;&nbsp;&nbsp; $134339644 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Health Care Equipment & Supplies | &nbsp;&nbsp; 145366434 | &nbsp;&nbsp;&nbsp;&nbsp; — | &nbsp;&nbsp;&nbsp;&nbsp; 148906 | &nbsp;&nbsp;&nbsp;&nbsp; 145515340 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Health Care Providers & Services | &nbsp;&nbsp; 68488793 | &nbsp;&nbsp;&nbsp;&nbsp; — | &nbsp;&nbsp;&nbsp;&nbsp; — | &nbsp;&nbsp;&nbsp;&nbsp; 68488793 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Health Care Technology | &nbsp;&nbsp; 2720975 | &nbsp;&nbsp;&nbsp;&nbsp; — | &nbsp;&nbsp;&nbsp;&nbsp; 1463 | &nbsp;&nbsp;&nbsp;&nbsp; 2722438 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Life Sciences Tools & Services | &nbsp;&nbsp; 48247073 | &nbsp;&nbsp;&nbsp;&nbsp; — | &nbsp;&nbsp;&nbsp;&nbsp; — | &nbsp;&nbsp;&nbsp;&nbsp; 48247073 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Pharmaceuticals | &nbsp;&nbsp; 105577483 | &nbsp;&nbsp;&nbsp;&nbsp; 11628539 | &nbsp;&nbsp;&nbsp;&nbsp; — | &nbsp;&nbsp;&nbsp;&nbsp; 117206022 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Other Interests | &nbsp;&nbsp; — | &nbsp;&nbsp;&nbsp;&nbsp; — | &nbsp;&nbsp;&nbsp;&nbsp; 62679 | &nbsp;&nbsp;&nbsp;&nbsp; 62679 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Preferred Securities |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Preferred Stocks | &nbsp;&nbsp; — | &nbsp;&nbsp;&nbsp;&nbsp; — | &nbsp;&nbsp;&nbsp;&nbsp; 3088691 | &nbsp;&nbsp;&nbsp;&nbsp; 3088691 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Rights | &nbsp;&nbsp; — | &nbsp;&nbsp;&nbsp;&nbsp; — | &nbsp;&nbsp;&nbsp;&nbsp; 59676 | &nbsp;&nbsp;&nbsp;&nbsp; 59676 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Warrants | &nbsp;&nbsp; 818 | &nbsp;&nbsp;&nbsp;&nbsp; — | &nbsp;&nbsp;&nbsp;&nbsp; — | &nbsp;&nbsp;&nbsp;&nbsp; 818 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Short-Term Securities  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Money Market Funds | &nbsp;&nbsp; 8093300 | &nbsp;&nbsp;&nbsp;&nbsp; — | &nbsp;&nbsp;&nbsp;&nbsp; — | &nbsp;&nbsp;&nbsp;&nbsp; 8093300 |
|  | &nbsp;&nbsp; $512110800 | &nbsp;&nbsp;&nbsp;&nbsp; $12352259 | &nbsp;&nbsp;&nbsp;&nbsp; $3361415 | &nbsp;&nbsp;&nbsp;&nbsp; $527824474 |
| Derivative Financial Instruments<sup>(a)</sup> <br>|  |  |  |  |
| &nbsp;&nbsp;&nbsp; Liabilities  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Equity Contracts | &nbsp;&nbsp; $(5138674)<br>| &nbsp;&nbsp;&nbsp;&nbsp; $(1307387)<br>| &nbsp;&nbsp;&nbsp;&nbsp; $— | &nbsp;&nbsp;&nbsp;&nbsp; $(6446061)<br>|

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

<sup>(a)</sup> Derivative financial instruments are options written. Options written are shown at value.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

---

| | |
|:---|:---|
| **Currency Abbreviation**  | **Currency Abbreviation**  |
| CHF | Swiss Franc |
| DKK | Danish Krone |
| EUR | Euro |
| GBP | British Pound |
| JPY | Japanese Yen |
| USD | United States Dollar |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

---

| | |
|:---|:---|
| **Portfolio Abbreviation**  | **Portfolio Abbreviation**  |
| ADR | American Depositary Receipt |
| CVR | Contingent Value Right |

---

Schedule of Investments

------

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** BlackRock Health Sciences Trust

- **b. Investment Company Act file number:** 811-21702

- **c. CIK number of Registrant:** 0001314966

- **d. LEI of Registrant:** 4UL0KI4EPYFKMUU31I34

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 100 BELLEVUE PARKWAY

  - **City:** WILMINGTON

  - **State:** DE

  - **Foreign country:** US

  - **Zip / Postal Code:** 19809

  - **Telephone number:** 800-441-7762

**Item A.2. Information about the Series.**

- **a. Name of Series:** BlackRock Health Sciences Trust

- **c. LEI of Series:** 4UL0KI4EPYFKMUU31I34

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2025-12-31

- **b. Date as of which information is reported:** 2025-09-30

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $534065264.37

**Total Liabilities:** $13693435.44

**Net Assets:** $520371828.93

**Cash Not Reported:** $228954.88

**Monthly Return Information**

| Class        | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID N/A | -1.29%               | 4.37%                | 1.56%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $6351091.27              | $-14927259.22                              |
| Month 2  | $-2251964.85             | $26137172.25                               |
| Month 3  | $22684.17                | $8937601.36                                |

**Designated Index Information**

- **Index Name:** MSCI USA IMI Health Care Call Overwrite Index

- **Index Identifier:** N/A

### Schedule of Portfolio Investments

| Name                                         | Title                                                   | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Ionis Pharmaceuticals Inc                    | Ionis Pharmaceuticals Inc                               | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |     15357 | NS      | $1004654.94   | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| TScan Therapeutics Inc                       | TScan Therapeutics Inc                                  | CUSIP: 89854M101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     49480 | NS      | $90053.60     | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | WATERS CORP                                             | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -48 | NC      | $-19320.00    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Charles River Laboratories International Inc | Charles River Laboratories International Inc            | CUSIP: 159864107<br>LEI: 549300BSQ0R4UZ5KX287 | Long             | EC               | CORP              | US        |      5060 | NS      | $791687.60    | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | BOSTON SCIENTIFIC CORP                                  | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -163 | NC      | $-10595.00    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | ELI LILLY + CO                                          | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -81 | NC      | $-262440.00   | -0.05%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | IQVIA HOLDINGS INC                                      | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -61 | NC      | $-18757.50    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Galderma Group AG                            | Galderma Group AG                                       | CUSIP: 000000000<br>LEI: 89450001OK6O8ELQ4584 | Long             | EC               | CORP              | CH        |     13599 | NS      | $2404306.34   | 0.46%             |  |  |  | No            |                  2 | On Loan: No      |
| Options Clearing Corp.                       | WAVE LIFE SCIENCES LTD                                  | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | SG        |       -38 | NC      | $-2660.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| GENESIS THERAPEUTICS INC                     | GENESIS THERAPEUTICS INC                                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     57170 | NS      | $316721.80    | 0.06%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Options Clearing Corp.                       | BRUKER CORP                                             | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -100 | NC      | $-1500.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | ABBOTT LABORATORIES                                     | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -220 | NC      | $-45540.00    | -0.01%            |  |  |  | No            |                  1 | On Loan: No      |
| Protagonist Therapeutics Inc                 | Protagonist Therapeutics Inc                            | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     32859 | NS      | $2182823.37   | 0.42%             |  |  |  | No            |                  1 | On Loan: No      |
| Rhythm Pharmaceuticals Inc                   | Rhythm Pharmaceuticals Inc                              | CUSIP: 76243J105<br>LEI: 529900JPNWXQ8DPLA551 | Long             | EC               | CORP              | US        |     55078 | NS      | $5562327.22   | 1.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals Inc                  | Alnylam Pharmaceuticals Inc                             | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |     31166 | NS      | $14211696.00  | 2.73%             |  |  |  | No            |                  1 | On Loan: No      |
| BioNTech SE                                  | BioNTech SE                                             | CUSIP: 09075V102<br>LEI: 894500UZJ5LG1F8J1U58 | Long             | EC               | CORP              | DE        |      3788 | NS      | $373572.56    | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| BANK OF AMERICA NA                           | NOV25 TMO US C @ 490.781                                | CUSIP: 000000000<br>LEI: B4TYDEB6GKMZO031MB27 | N/A              | DE               |  | US        |     -9800 | NC      | $-186436.38   | -0.04%            |  |  |  | No            |                  2 | On Loan: No      |
| BARCLAYS BANK PLC                            | OCT25 COR US C @ 303.982                                | CUSIP: 000000000<br>LEI: G5GSEF7VJP5I7OUK5573 | N/A              | DE               |  | US        |     -6200 | NC      | $-53501.16    | -0.01%            |  |  |  | No            |                  2 | On Loan: No      |
| Options Clearing Corp.                       | PFIZER INC                                              | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -385 | NC      | $-30415.00    | -0.01%            |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals Inc                   | Vertex Pharmaceuticals Inc                              | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |     12835 | NS      | $5026699.40   | 0.97%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | PTC THERAPEUTICS INC                                    | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -83 | NC      | $-10167.50    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | MEDTRONIC PLC                                           | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | IE        |      -324 | NC      | $-91368.00    | -0.02%            |  |  |  | No            |                  1 | On Loan: No      |
| BridgeBio Oncology Therapeutics Inc          | BridgeBio Oncology Therapeutics Inc                     | CUSIP: 107924102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     61530 | NS      | $712517.40    | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| Johnson & Johnson                            | Johnson & Johnson                                       | CUSIP: 478160104<br>LEI: 549300G0CFPGEF6X2043 | Long             | EC               | CORP              | US        |    230823 | NS      | $42799200.66  | 8.22%             |  |  |  | No            |                  1 | On Loan: No      |
| BARCLAYS BANK PLC                            | NOV25 ASND US C @ 204.97                                | CUSIP: 000000000<br>LEI: G5GSEF7VJP5I7OUK5573 | N/A              | DE               |  | US        |     -3700 | NC      | $-33217.49    | -0.01%            |  |  |  | No            |                  2 | On Loan: No      |
| Options Clearing Corp.                       | MEDTRONIC PLC                                           | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | IE        |       -99 | NC      | $-17919.00    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | LABCORP HOLDINGS INC                                    | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -67 | NC      | $-124620.00   | -0.02%            |  |  |  | No            |                  1 | On Loan: No      |
| UnitedHealth Group Inc                       | UnitedHealth Group Inc                                  | CUSIP: 91324P102<br>LEI: 549300GHBMY8T5GXDE41 | Long             | EC               | CORP              | US        |     63340 | NS      | $21871302.00  | 4.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Exact Sciences Corp                          | Exact Sciences Corp                                     | CUSIP: 30063P105<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |     49509 | NS      | $2708637.39   | 0.52%             |  |  |  | No            |                  1 | On Loan: No      |
| MORGAN STANLEY & CO. INTERNATIONAL           | NOV25 BEAM US C @ 26.291                                | CUSIP: 000000000<br>LEI: 4PQUHN3JPFGFNF3BB653 | N/A              | DE               |  | US        |     -3000 | NC      | $-4563.81     | -0.00%            |  |  |  | No            |                  2 | On Loan: No      |
| Repligen Corp                                | Repligen Corp                                           | CUSIP: 759916109<br>LEI: 54930006QJ0T5AUO1E71 | Long             | EC               | CORP              | US        |     12836 | NS      | $1715788.12   | 0.33%             |  |  |  | No            |                  1 | On Loan: No      |
| CONTRA MIRATI THERAPEU                       | CONTRA MIRATI THERAPEU                                  | CUSIP: 604CVR027<br>LEI: 529900GYRW59IDQV6N54 | Long             |  | CORP              | US        |     15747 | NS      | $12282.66     | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| LARONDE INC                                  | LARONDE INC                                             | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     21100 | NS      | $512730.00    | 0.10%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Options Clearing Corp.                       | ABBVIE INC                                              | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -248 | NC      | $-542500.00   | -0.10%            |  |  |  | No            |                  1 | On Loan: No      |
| CONTRA FREQUENCY THERA                       | CONTRA FREQUENCY THERA                                  | CUSIP: 358CVR025<br>LEI: N/A                  | Long             |  | CORP              | US        |     28060 | NS      | $0.28         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Options Clearing Corp.                       | EXELIXIS INC                                            | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -103 | NC      | $-13132.50    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| MBX Biosciences Inc                          | MBX Biosciences Inc                                     | CUSIP: 55287L101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     29168 | NS      | $510440.00    | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | INSPIRE MEDICAL SYSTEMS INC                             | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -17 | NC      | $-935.00      | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | BOSTON SCIENTIFIC CORP                                  | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -281 | NC      | $-20372.50    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| EXO IMAGING INC                              | EXO IMAGING INC                                         | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1017 | NS      | $366.27       | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Merus NV                                     | Merus NV                                                | CUSIP: 000000000<br>LEI: 549300W8GPUWU8QNU293 | Long             | EC               | CORP              | NL        |     18404 | NS      | $1732736.60   | 0.33%             |  |  |  | No            |                  1 | On Loan: No      |
| AbbVie Inc                                   | AbbVie Inc                                              | CUSIP: 00287Y109<br>LEI: FR5LCKFTG8054YNNRU85 | Long             | EC               | CORP              | US        |    106461 | NS      | $24649979.94  | 4.74%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | VIKING THERAPEUTICS INC                                 | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -36 | NC      | $-4860.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | BIONTECH SE                                             | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | DE        |       -14 | NC      | $-1610.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| CONTRA BLUEPRINT MEDIC                       | CONTRA BLUEPRINT MEDIC                                  | CUSIP: 096CVR048<br>LEI: 5299004CC60O9T5HVM83 | Long             |  | CORP              | US        |     15552 | NS      | $15085.44     | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Options Clearing Corp.                       | TEVA PHARMACEUTICAL INDUSTRIES                          | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | IL        |      -462 | NC      | $-41811.00    | -0.01%            |  |  |  | No            |                  1 | On Loan: No      |
| SUSQUEHANNA FINANCIAL GROUP LLLP             | BBIO.FLEX                                               | CUSIP: 000000000<br>LEI: 549300E8QX0ZMRDC2M81 | N/A              | DE               |  | US        |       -70 | NC      | $-23881.34    | -0.00%            |  |  |  | No            |                  2 | On Loan: No      |
| Options Clearing Corp.                       | ELEVANCE HEALTH INC                                     | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -16 | NC      | $-2720.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Thermo Fisher Scientific Inc                 | Thermo Fisher Scientific Inc                            | CUSIP: 883556102<br>LEI: HCHV7422L5HDJZCRFL38 | Long             | EC               | CORP              | US        |     37523 | NS      | $18199405.46  | 3.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | DEXCOM INC                                              | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -102 | NC      | $-16320.00    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Dyne Therapeutics Inc                        | Dyne Therapeutics Inc                                   | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     24506 | NS      | $310000.90    | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | REGENERON PHARMACEUTICALS INC                           | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -17 | NC      | $-7905.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Nyxoah SA                                    | Nyxoah SA                                               | CUSIP: 000000000<br>LEI: 5493002O1ESKZ18OXR80 | Long             | EC               | CORP              | BE        |     29870 | NS      | $137402.00    | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Upstream Bio Inc                             | Upstream Bio Inc                                        | CUSIP: 91678A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     17345 | NS      | $326259.45    | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Agilent Technologies Inc                     | Agilent Technologies Inc                                | CUSIP: 00846U101<br>LEI: QUIX8Y7A2WP0XRMW7G29 | Long             | EC               | CORP              | US        |     37005 | NS      | $4749591.75   | 0.91%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | KYMERA THERAPEUTICS INC                                 | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -18 | NC      | $-7830.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | METTLER-TOLEDO INTERNATIONAL I                          | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |        -2 | NC      | $-960.00      | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| CELLARITY INC                                | CELLARITY INC                                           | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     44167 | NS      | $90542.35     | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| BioMarin Pharmaceutical Inc                  | BioMarin Pharmaceutical Inc                             | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |     30316 | NS      | $1641914.56   | 0.32%             |  |  |  | No            |                  1 | On Loan: No      |
| NUCLEIX LTD                                  | NUCLEIX LTD                                             | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    367395 | NS      | $224110.95    | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| SWIFT HEALTH SYSTEMS INC                     | SWIFT HEALTH SYSTEMS INC                                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |        93 | NS      | $206.45       | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| KARTOS THERAPEUTICS INC                      | KARTOS THERAPEUTICS INC                                 | CUSIP: 000000000<br>LEI: N/A                  | Long             | STIV             | CORP              | US        |     23610 | NS      | $134104.80    | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Options Clearing Corp.                       | EDWARDS LIFESCIENCES CORP                               | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -385 | NC      | $-116462.50   | -0.02%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | ALNYLAM PHARMACEUTICALS INC                             | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -68 | NC      | $-21930.00    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Cooper Cos Inc/The                           | Cooper Cos Inc/The                                      | CUSIP: 216648501<br>LEI: QJKMVPIGLH7530PCUE20 | Long             | EC               | CORP              | US        |     27416 | NS      | $1879640.96   | 0.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Beam Therapeutics Inc                        | Beam Therapeutics Inc                                   | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     14977 | NS      | $363491.79    | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| MORGAN STANLEY & CO. INTERNATIONAL           | NOV25 NUVL US C @ 80.433                                | CUSIP: 000000000<br>LEI: 4PQUHN3JPFGFNF3BB653 | N/A              | DE               |  | US        |    -11100 | NC      | $-130649.33   | -0.03%            |  |  |  | No            |                  2 | On Loan: No      |
| NUCLEIX LTD                                  | NUCLEIX LTD                                             | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       200 | NS      | $148540.00    | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Options Clearing Corp.                       | VERTEX PHARMACEUTICALS INC                              | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -24 | NC      | $-11520.00    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| HeartFlow Inc                                | HeartFlow Inc                                           | CUSIP: 42238D107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1890 | NS      | $63617.40     | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | ALCON AG                                                | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | CH        |       -22 | NC      | $-440.00      | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | GUARDANT HEALTH INC                                     | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -48 | NC      | $-34320.00    | -0.01%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | INCYTE CORP                                             | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -69 | NC      | $-5002.50     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| MORGAN STANLEY & CO. INTERNATIONAL           | NOV25 PEN US C @ 261.875                                | CUSIP: 000000000<br>LEI: 4PQUHN3JPFGFNF3BB653 | N/A              | DE               |  | US        |     -4500 | NC      | $-48205.40    | -0.01%            |  |  |  | No            |                  2 | On Loan: No      |
| Bruker Corp                                  | Bruker Corp                                             | CUSIP: 116794108<br>LEI: LEBZ6VLQ6I8XB1NHVY15 | Long             | EC               | CORP              | US        |     44389 | NS      | $1442198.61   | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | STERIS PLC                                              | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | IE        |        -4 | NC      | $-620.00      | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Alcon AG                                     | Alcon AG                                                | CUSIP: 000000000<br>LEI: 549300LDT5AP8S0NBM78 | Long             | EC               | CORP              | CH        |      5895 | NS      | $439236.45    | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Novocure Ltd                                 | Novocure Ltd                                            | CUSIP: 000000000<br>LEI: 213800YPP55UMHWA4826 | Long             | EC               | CORP              | JE        |     51195 | NS      | $661439.40    | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Medtronic PLC                                | Medtronic PLC                                           | CUSIP: 000000000<br>LEI: 549300GX3ZBSQWUXY261 | Long             | EC               | CORP              | IE        |    187946 | NS      | $17899977.04  | 3.44%             |  |  |  | No            |                  1 | On Loan: No      |
| BNP PARIBAS SA                               | NOV25 TECH US C @ 55.825                                | CUSIP: 000000000<br>LEI: QHSFEYI7HUOXXZ413E03 | N/A              | DE               |  | US        |     -6600 | NC      | $-21296.55    | -0.00%            |  |  |  | No            |                  2 | On Loan: No      |
| SUSQUEHANNA FINANCIAL GROUP LLLP             | COR.FLEX                                                | CUSIP: 000000000<br>LEI: 549300E8QX0ZMRDC2M81 | N/A              | DE               |  | US        |       -39 | NC      | $-79853.94    | -0.02%            |  |  |  | No            |                  2 | On Loan: No      |
| Options Clearing Corp.                       | HCA HEALTHCARE INC                                      | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -47 | NC      | $-119145.00   | -0.02%            |  |  |  | No            |                  1 | On Loan: No      |
| Centene Corp                                 | Centene Corp                                            | CUSIP: 15135B101<br>LEI: 549300Z7JJ4TQSQGT333 | Long             | EC               | CORP              | US        |     49135 | NS      | $1753136.80   | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | RHYTHM PHARMACEUTICALS INC                              | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -103 | NC      | $-88580.00    | -0.02%            |  |  |  | No            |                  1 | On Loan: No      |
| Zealand Pharma A/S                           | Zealand Pharma A/S                                      | CUSIP: 000000000<br>LEI: 549300ITBB1ULBL4CZ12 | Long             | EC               | CORP              | DK        |      7367 | NS      | $543279.66    | 0.10%             |  |  |  | No            |                  2 | On Loan: No      |
| Options Clearing Corp.                       | DANAHER CORP                                            | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -108 | NC      | $-96120.00    | -0.02%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | INSULET CORP                                            | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -30 | NC      | $-10500.00    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Ascendis Pharma A/S                          | Ascendis Pharma A/S                                     | CUSIP: 04351P101<br>LEI: 549300B66JN3W3J8GH73 | Long             | EC               | CORP              | DK        |      7949 | NS      | $1580340.69   | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| MORGAN STANLEY & CO. INTERNATIONAL           | NOV25 MRUS US C @ 69.278                                | CUSIP: 000000000<br>LEI: 4PQUHN3JPFGFNF3BB653 | N/A              | DE               |  | US        |     -7000 | NC      | $-176379.84   | -0.03%            |  |  |  | No            |                  2 | On Loan: No      |
| Options Clearing Corp.                       | DANAHER CORP                                            | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -60 | NC      | $-30600.00    | -0.01%            |  |  |  | No            |                  1 | On Loan: No      |
| Boston Scientific Corp                       | Boston Scientific Corp                                  | CUSIP: 101137107<br>LEI: Y6ZDD9FP4P8JSSJMW954 | Long             | EC               | CORP              | US        |    215674 | NS      | $21056252.62  | 4.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Elevance Health Inc                          | Elevance Health Inc                                     | CUSIP: 036752103<br>LEI: 8MYN82XMYQH89CTMTH67 | Long             | EC               | CORP              | US        |      7850 | NS      | $2536492.00   | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen Inc                                   | Biogen Inc                                              | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |     29185 | NS      | $4088234.80   | 0.79%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | MODERNA INC                                             | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -123 | NC      | $-20295.00    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Inspire Medical Systems Inc                  | Inspire Medical Systems Inc                             | CUSIP: 457730109<br>LEI: 549300XQQCQ7HCJKTW25 | Long             | EC               | CORP              | US        |      4705 | NS      | $349111.00    | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| CONTRA ABIOMED INC                           | CONTRA ABIOMED INC                                      | CUSIP: 003CVR016<br>LEI: N/A                  | Long             |  | CORP              | US        |     14359 | NS      | $32307.75     | 0.01%             |  |  |  | No            |                  3 | On Loan: No      |
| Options Clearing Corp.                       | EDWARDS LIFESCIENCES CORP                               | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -394 | NC      | $-70920.00    | -0.01%            |  |  |  | No            |                  1 | On Loan: No      |
| Daiichi Sankyo Co Ltd                        | Daiichi Sankyo Co Ltd                                   | CUSIP: 000000000<br>LEI: 353800XGIU2IHQGC9504 | Long             | EC               | CORP              | JP        |     62300 | NS      | $1401762.09   | 0.27%             |  |  |  | No            |                  2 | On Loan: No      |
| United Therapeutics Corp                     | United Therapeutics Corp                                | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |      4080 | NS      | $1710376.80   | 0.33%             |  |  |  | No            |                  1 | On Loan: No      |
| BlackRock Funds III                          | BlackRock Cash Funds: Institutional, SL Agency Shares   | CUSIP: 066922519<br>LEI: 5493008LW2651I1QB503 | Long             | STIV             | RF                | US        |    755422 | NS      | $755799.54    | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | REPLIGEN CORP                                           | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -36 | NC      | $-16380.00    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | INSMED INC                                              | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -113 | NC      | $-32487.50    | -0.01%            |  |  |  | No            |                  1 | On Loan: No      |
| Nuvation Bio Inc                             | Nuvation Bio Inc                                        | CUSIP: 67080N119<br>LEI: N/A                  | N/A              | DE               |  | US        |      4050 | NS      | $818.51       | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | ARCELLX INC                                             | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -62 | NC      | $-50530.00    | -0.01%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | ARGENX SE                                               | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | NL        |       -21 | NC      | $-25725.00    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Insulet Corp                                 | Insulet Corp                                            | CUSIP: 45784P101<br>LEI: 549300TZTYD2PYN92D43 | Long             | EC               | CORP              | US        |      8004 | NS      | $2471074.92   | 0.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Viking Therapeutics Inc                      | Viking Therapeutics Inc                                 | CUSIP: 92686J106<br>LEI: 529900IVC72YPFA25M37 | Long             | EC               | CORP              | US        |      9491 | NS      | $249423.48    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Becton Dickinson & Co                        | Becton Dickinson & Co                                   | CUSIP: 075887109<br>LEI: ICE2EP6D98PQUILVRZ91 | Long             | EC               | CORP              | US        |     38538 | NS      | $7213157.46   | 1.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | PROTAGONIST THERAPEUTICS INC                            | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -43 | NC      | $-32250.00    | -0.01%            |  |  |  | No            |                  1 | On Loan: No      |
| Penumbra Inc                                 | Penumbra Inc                                            | CUSIP: 70975L107<br>LEI: 549300RGE06P3ECANU72 | Long             | EC               | CORP              | US        |     11896 | NS      | $3013494.72   | 0.58%             |  |  |  | No            |                  1 | On Loan: No      |
| IQVIA Holdings Inc                           | IQVIA Holdings Inc                                      | CUSIP: 46266C105<br>LEI: 549300W3R20NM4KQPH86 | Long             | EC               | CORP              | US        |     16167 | NS      | $3070759.98   | 0.59%             |  |  |  | No            |                  1 | On Loan: No      |
| Veeva Systems Inc                            | Veeva Systems Inc                                       | CUSIP: 922475108<br>LEI: 549300YZEXPDB92M2F02 | Long             | EC               | CORP              | US        |      8920 | NS      | $2657357.20   | 0.51%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | BIOMARIN PHARMACEUTICAL INC                             | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -40 | NC      | $-2900.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | ILLUMINA INC                                            | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -51 | NC      | $-3952.50     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | ALNYLAM PHARMACEUTICALS INC                             | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -50 | NC      | $-41750.00    | -0.01%            |  |  |  | No            |                  1 | On Loan: No      |
| Moderna Inc                                  | Moderna Inc                                             | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |     32542 | NS      | $840559.86    | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Biohaven Ltd                                 | Biohaven Ltd                                            | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | VG        |     18429 | NS      | $276619.29    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Stryker Corp                                 | Stryker Corp                                            | CUSIP: 863667101<br>LEI: 5493002F0SC4JTBU5137 | Long             | EC               | CORP              | US        |     48820 | NS      | $18047289.40  | 3.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | MEDTRONIC PLC                                           | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | IE        |      -222 | NC      | $-36852.00    | -0.01%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | NEUROCRINE BIOSCIENCES INC                              | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -24 | NC      | $-1800.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| BARCLAYS BANK PLC                            | NOV25 DGX US C @ 190.241                                | CUSIP: 000000000<br>LEI: G5GSEF7VJP5I7OUK5573 | N/A              | DE               |  | US        |     -9200 | NC      | $-56233.44    | -0.01%            |  |  |  | No            |                  2 | On Loan: No      |
| Cigna Group/The                              | Cigna Group/The                                         | CUSIP: 125523100<br>LEI: 549300VIWYMSIGT1U456 | Long             | EC               | CORP              | US        |      9313 | NS      | $2684472.25   | 0.52%             |  |  |  | No            |                  1 | On Loan: No      |
| BlackRock Liquidity Funds                    | BlackRock Liquidity Funds: T-Fund, Institutional Shares | CUSIP: 09248U718<br>LEI: 5493007YVNX55LTRQ706 | Long             | STIV             | RF                | US        |   7130620 | NS      | $7130619.70   | 1.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Disc Medicine Inc                            | Disc Medicine Inc                                       | CUSIP: 254604101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7717 | NS      | $509939.36    | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| CVS Health Corp                              | CVS Health Corp                                         | CUSIP: 126650100<br>LEI: 549300EJG376EN5NQE29 | Long             | EC               | CORP              | US        |     32565 | NS      | $2455075.35   | 0.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Denali Therapeutics Inc                      | Denali Therapeutics Inc                                 | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |     20283 | NS      | $294509.16    | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Illumina Inc                                 | Illumina Inc                                            | CUSIP: 452327109<br>LEI: SQ95QG8SR5Q56LSNF682 | Long             | EC               | CORP              | US        |     13625 | NS      | $1293966.25   | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | VERTEX PHARMACEUTICALS INC                              | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -24 | NC      | $-1740.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Orchestra BioMed Holdings Inc                | Orchestra BioMed Holdings Inc                           | CUSIP: 68572M106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     18076 | NS      | $44828.48     | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| SUSQUEHANNA FINANCIAL GROUP LLLP             | PTGX.FLEX                                               | CUSIP: 000000000<br>LEI: 549300E8QX0ZMRDC2M81 | N/A              | DE               |  | US        |       -81 | NC      | $-45894.76    | -0.01%            |  |  |  | No            |                  2 | On Loan: No      |
| BANK OF AMERICA NA                           | OCT25 UCB BB C @ 215.373                                | CUSIP: 000000000<br>LEI: B4TYDEB6GKMZO031MB27 | N/A              | DE               |  | US        |     -3800 | NC      | $-95519.31    | -0.02%            |  |  |  | No            |                  2 | On Loan: No      |
| BANK OF AMERICA NA                           | OCT25 ZEAL DC C @ 354.795                               | CUSIP: 000000000<br>LEI: B4TYDEB6GKMZO031MB27 | N/A              | DE               |  | US        |     -2700 | NC      | $-45207.48    | -0.01%            |  |  |  | No            |                  2 | On Loan: No      |
| BARCLAYS BANK PLC                            | NOV25 WST US C @ 260.59                                 | CUSIP: 000000000<br>LEI: G5GSEF7VJP5I7OUK5573 | N/A              | DE               |  | US        |     -3800 | NC      | $-62013.34    | -0.01%            |  |  |  | No            |                  2 | On Loan: No      |
| Options Clearing Corp.                       | PFIZER INC                                              | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -106 | NC      | $-5194.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| AFFINIVAX INC                                | AFFINIVAX INC                                           | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6331 | NS      | $62676.90     | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Guardant Health Inc                          | Guardant Health Inc                                     | CUSIP: 40131M109<br>LEI: 254900M8C3E5VC8BR186 | Long             | EC               | CORP              | US        |     31531 | NS      | $1970056.88   | 0.38%             |  |  |  | No            |                  1 | On Loan: No      |
| WaVe Life Sciences Ltd                       | WaVe Life Sciences Ltd                                  | CUSIP: 000000000<br>LEI: 54930070006GPKFYZ813 | Long             | EC               | CORP              | SG        |     24727 | NS      | $181001.64    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| GOLDMAN SACHS INTERNATIONAL                  | OCT25 GALD SW C @ 141.678                               | CUSIP: 000000000<br>LEI: W22LROWP2IHZNBB6K528 | N/A              | DE               |  | US        |     -3900 | NC      | $-8665.94     | -0.00%            |  |  |  | No            |                  2 | On Loan: No      |
| Incyte Corp                                  | Incyte Corp                                             | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |     33103 | NS      | $2807465.43   | 0.54%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | ABBOTT LABORATORIES                                     | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -246 | NC      | $-27921.00    | -0.01%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | VEEVA SYSTEMS INC                                       | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -33 | NC      | $-69300.00    | -0.01%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | GILEAD SCIENCES INC                                     | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -341 | NC      | $-81328.50    | -0.02%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | TEVA PHARMACEUTICAL INDUSTRIES                          | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | IL        |      -462 | NC      | $-35574.00    | -0.01%            |  |  |  | No            |                  1 | On Loan: No      |
| NOMURA SECURITIES INTERNATIONAL INC          | IRON US FLEX                                            | CUSIP: 000000000<br>LEI: OXTKY6Q8X53C9ILVV871 | N/A              | DE               |  | US        |       -29 | NC      | $-15521.15    | -0.00%            |  |  |  | No            |                  2 | On Loan: No      |
| AstraZeneca PLC                              | AstraZeneca PLC                                         | CUSIP: 000000000<br>LEI: PY6ZZQWO2IZFZC3IOL08 | Long             | EC               | CORP              | GB        |     32707 | NS      | $5010744.91   | 0.96%             |  |  |  | No            |                  2 | On Loan: No      |
| Intuitive Surgical Inc                       | Intuitive Surgical Inc                                  | CUSIP: 46120E602<br>LEI: 54930052SRG011710797 | Long             | EC               | CORP              | US        |     30454 | NS      | $13619942.42  | 2.62%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | SUMMIT THERAPEUTICS INC                                 | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -69 | NC      | $-8280.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | SCHOLAR ROCK HOLDING CORP                               | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -29 | NC      | $-3770.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| JANE STREET EXECUTION SERVICES, LLC          | CRL.FLEX                                                | CUSIP: 000000000<br>LEI: 549300HXJLXCPDWAH070 | N/A              | DE               |  | US        |       -19 | NC      | $-12086.34    | -0.00%            |  |  |  | No            |                  2 | On Loan: No      |
| Amgen Inc                                    | Amgen Inc                                               | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |     59717 | NS      | $16852137.40  | 3.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | VERTEX PHARMACEUTICALS INC                              | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -24 | NC      | $-17040.00    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | COOPER COS INC/THE                                      | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -104 | NC      | $-14040.00    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| SUSQUEHANNA FINANCIAL GROUP LLLP             | DNLI US FLEX                                            | CUSIP: 000000000<br>LEI: 549300E8QX0ZMRDC2M81 | N/A              | DE               |  | US        |       -77 | NC      | $-6394.31     | -0.00%            |  |  |  | No            |                  2 | On Loan: No      |
| Avidity Biosciences Inc                      | Avidity Biosciences Inc                                 | CUSIP: 05370A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8950 | NS      | $389951.50    | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | UNITED THERAPEUTICS CORP                                | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -15 | NC      | $-22650.00    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | MERCK + CO INC                                          | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -276 | NC      | $-120750.00   | -0.02%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | EXACT SCIENCES CORP                                     | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -132 | NC      | $-45540.00    | -0.01%            |  |  |  | No            |                  1 | On Loan: No      |
| Labcorp Holdings Inc                         | Labcorp Holdings Inc                                    | CUSIP: 504922105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     20462 | NS      | $5873821.72   | 1.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | BIOHAVEN LTD                                            | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | VG        |       -35 | NC      | $-3150.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| CARBON HEALTH TECHNOLOGIES INC               | CARBON HEALTH TECHNOLOGIES INC                          | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    146332 | NS      | $1463.32      | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| GOLDFINCH BIO INC                            | GOLDFINCH BIO INC                                       | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    190000 | NS      | $76000.00     | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Options Clearing Corp.                       | BIOHAVEN LTD                                            | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | VG        |       -35 | NC      | $-2100.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Autolus Therapeutics PLC                     | Autolus Therapeutics PLC                                | CUSIP: 05280R100<br>LEI: 549300C0KZP8EYROLL02 | Long             | EC               | CORP              | GB        |     64258 | NS      | $104740.54    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Quanta Dialysis Technologies Ltd             | Quanta Dialysis Technologies Ltd                        | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | GB        |   4243029 | NS      | $302441.72    | 0.06%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Options Clearing Corp.                       | BRUKER CORP                                             | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -68 | NC      | $-5440.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Abbott Laboratories                          | Abbott Laboratories                                     | CUSIP: 002824100<br>LEI: HQD377W2YR662HK5JX27 | Long             | EC               | CORP              | US        |    231527 | NS      | $31010726.38  | 5.96%             |  |  |  | No            |                  1 | On Loan: No      |
| Vaxcyte Inc                                  | Vaxcyte Inc                                             | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |      7730 | NS      | $278434.60    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| JANE STREET EXECUTION SERVICES, LLC          | RGEN.FLEX                                               | CUSIP: 000000000<br>LEI: 549300HXJLXCPDWAH070 | N/A              | DE               |  | US        |       -12 | NC      | $-12669.42    | -0.00%            |  |  |  | No            |                  2 | On Loan: No      |
| Options Clearing Corp.                       | BIOGEN INC                                              | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -74 | NC      | $-9250.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| GE HealthCare Technologies Inc               | GE HealthCare Technologies Inc                          | CUSIP: 36266G107<br>LEI: 549300OI9J7XOWZMUN85 | Long             | EC               | CORP              | US        |     21440 | NS      | $1610144.00   | 0.31%             |  |  |  | No            |                  1 | On Loan: No      |
| Bridgebio Pharma Inc                         | Bridgebio Pharma Inc                                    | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |     18507 | NS      | $961253.58    | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvalent Inc                                 | Nuvalent Inc                                            | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     29333 | NS      | $2536717.84   | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | BRISTOL-MYERS SQUIBB CO                                 | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -372 | NC      | $-53010.00    | -0.01%            |  |  |  | No            |                  1 | On Loan: No      |
| Kymera Therapeutics Inc                      | Kymera Therapeutics Inc                                 | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4830 | NS      | $273378.00    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Stoke Therapeutics Inc                       | Stoke Therapeutics Inc                                  | CUSIP: 86150R107<br>LEI: 549300RD25SS2DIJHJ67 | Long             | EC               | CORP              | US        |     69330 | NS      | $1629255.00   | 0.31%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | AMGEN INC                                               | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -99 | NC      | $-41085.00    | -0.01%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | BOSTON SCIENTIFIC CORP                                  | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -290 | NC      | $-14500.00    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Dexcom Inc                                   | Dexcom Inc                                              | CUSIP: 252131107<br>LEI: 549300YSK3QDSFR5EU59 | Long             | EC               | CORP              | US        |     38114 | NS      | $2564691.06   | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| ADARX PHARMACEUTICALS INC                    | ADARX PHARMACEUTICALS INC                               | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     52885 | NS      | $628802.65    | 0.12%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Arcellx Inc                                  | Arcellx Inc                                             | CUSIP: 03940C100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     16531 | NS      | $1357195.10   | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | GLAUKOS CORP                                            | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -29 | NC      | $-1885.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Pfizer Inc                                   | Pfizer Inc                                              | CUSIP: 717081103<br>LEI: 765LHXWGK1KXCLTFYQ30 | Long             | EC               | CORP              | US        |    106328 | NS      | $2709237.44   | 0.52%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | THERMO FISHER SCIENTIFIC INC                            | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -44 | NC      | $-35200.00    | -0.01%            |  |  |  | No            |                  1 | On Loan: No      |
| Bio-Techne Corp                              | Bio-Techne Corp                                         | CUSIP: 09073M104<br>LEI: 54930073RLKQ51TILZ35 | Long             | EC               | CORP              | US        |     17518 | NS      | $974526.34    | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | BIOGEN INC                                              | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -36 | NC      | $-7020.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Edgewise Therapeutics Inc                    | Edgewise Therapeutics Inc                               | CUSIP: 28036F105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     22836 | NS      | $370399.92    | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | STRYKER CORP                                            | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -185 | NC      | $-23125.00    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| UCB SA                                       | UCB SA                                                  | CUSIP: 000000000<br>LEI: 2138008J191VLSGY5A09 | Long             | EC               | CORP              | BE        |     10073 | NS      | $2811726.09   | 0.54%             |  |  |  | No            |                  2 | On Loan: No      |
| Edwards Lifesciences Corp                    | Edwards Lifesciences Corp                               | CUSIP: 28176E108<br>LEI: YA13X31F3V31L8TMPR58 | Long             | EC               | CORP              | US        |    205137 | NS      | $15953504.49  | 3.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | BECTON DICKINSON + CO                                   | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -146 | NC      | $-18615.00    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | NOVOCURE LTD                                            | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | JE        |      -194 | NC      | $-3395.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| UBS AG                                       | OCT25 GALD SW C @ 148.0885                              | CUSIP: 000000000<br>LEI: BFM8T61CT2L1QCEMIK50 | N/A              | DE               |  | US        |     -1200 | NC      | $-1973.80     | -0.00%            |  |  |  | No            |                  2 | On Loan: No      |
| Argenx SE                                    | Argenx SE                                               | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |      5763 | NS      | $4250558.28   | 0.82%             |  |  |  | No            |                  1 | On Loan: No      |
| Legend Biotech Corp                          | Legend Biotech Corp                                     | CUSIP: 52490G102<br>LEI: 254900EIUFZTW136H859 | Long             | EC               | CORP              | KY        |     11174 | NS      | $364384.14    | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Cencora Inc                                  | Cencora Inc                                             | CUSIP: 03073E105<br>LEI: AI8GXW8LG5WK7E9UD086 | Long             | EC               | CORP              | US        |     26637 | NS      | $8324861.61   | 1.60%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | LABCORP HOLDINGS INC                                    | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |        -5 | NC      | $-7550.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | GE HEALTHCARE TECHNOLOGIES INC                          | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -43 | NC      | $-9137.50     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| BANK OF AMERICA NA                           | NOV25 AZN LN C @ 114.8316                               | CUSIP: 000000000<br>LEI: B4TYDEB6GKMZO031MB27 | N/A              | DE               |  | US        |     -3300 | NC      | $-10667.72    | -0.00%            |  |  |  | No            |                  2 | On Loan: No      |
| Insmed Inc                                   | Insmed Inc                                              | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |     52511 | NS      | $7562109.11   | 1.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcus Biosciences Inc                        | Arcus Biosciences Inc                                   | CUSIP: 03969F109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     26855 | NS      | $365228.00    | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| UBS AG                                       | NOV25 4568 JP C @ 3561.9413                             | CUSIP: 000000000<br>LEI: BFM8T61CT2L1QCEMIK50 | N/A              | DE               |  | US        |    -23600 | NC      | $-7782.24     | -0.00%            |  |  |  | No            |                  2 | On Loan: No      |
| Options Clearing Corp.                       | INTUITIVE SURGICAL INC                                  | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -115 | NC      | $-65550.00    | -0.01%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | STOKE THERAPEUTICS INC                                  | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -263 | NC      | $-26300.00    | -0.01%            |  |  |  | No            |                  1 | On Loan: No      |
| LB Pharmaceuticals Inc                       | LB Pharmaceuticals Inc                                  | CUSIP: 50180M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     48308 | NS      | $762783.32    | 0.15%             |  |  |  | No            |                  1 | On Loan: —       |
| Voyager Therapeutics Inc                     | Voyager Therapeutics Inc                                | CUSIP: 92915B106<br>LEI: 54930082S4XVR0ZWCC74 | Long             | EC               | CORP              | US        |     32205 | NS      | $150397.35    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Vir Biotechnology Inc                        | Vir Biotechnology Inc                                   | CUSIP: 92764N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     20570 | NS      | $117454.70    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| MORGAN STANLEY & CO. INTERNATIONAL           | NOV25 NTRA US C @ 179.01                                | CUSIP: 000000000<br>LEI: 4PQUHN3JPFGFNF3BB653 | N/A              | DE               |  | US        |      -300 | NC      | $-1321.42     | -0.00%            |  |  |  | No            |                  2 | On Loan: No      |
| Options Clearing Corp.                       | ABBOTT LABORATORIES                                     | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -413 | NC      | $-162102.50   | -0.03%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | UNITEDHEALTH GROUP INC                                  | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -227 | NC      | $-125985.00   | -0.02%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | PFIZER INC                                              | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -105 | NC      | $-10290.00    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Tenet Healthcare Corp                        | Tenet Healthcare Corp                                   | CUSIP: 88033G407<br>LEI: 0W9AIBT6U6ADJ2I8HK17 | Long             | EC               | CORP              | US        |      9500 | NS      | $1928880.00   | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Natera Inc                                   | Natera Inc                                              | CUSIP: 632307104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     12117 | NS      | $1950473.49   | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences Inc                   | Neurocrine Biosciences Inc                              | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |     11545 | NS      | $1620687.10   | 0.31%             |  |  |  | No            |                  1 | On Loan: No      |
| SUSQUEHANNA FINANCIAL GROUP LLLP             | STE.FLEX                                                | CUSIP: 000000000<br>LEI: 549300E8QX0ZMRDC2M81 | N/A              | DE               |  | US        |       -18 | NC      | $-11071.10    | -0.00%            |  |  |  | No            |                  2 | On Loan: No      |
| Exelixis Inc                                 | Exelixis Inc                                            | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |     27330 | NS      | $1128729.00   | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | EXACT SCIENCES CORP                                     | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -56 | NC      | $-20160.00    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| HCA Healthcare Inc                           | HCA Healthcare Inc                                      | CUSIP: 40412C101<br>LEI: 529900PH4ZGUH2MNEU89 | Long             | EC               | CORP              | US        |     12565 | NS      | $5355203.00   | 1.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | VIKING THERAPEUTICS INC                                 | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -18 | NC      | $-990.00      | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | BIOMARIN PHARMACEUTICAL INC                             | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -75 | NC      | $-937.50      | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Bio-Rad Laboratories Inc                     | Bio-Rad Laboratories Inc                                | CUSIP: 090572207<br>LEI: 549300ZC1GPV35XYDK53 | Long             | EC               | CORP              | US        |      2236 | NS      | $626952.04    | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | CVS HEALTH CORP                                         | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -22 | NC      | $-5841.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | ELI LILLY + CO                                          | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -63 | NC      | $-160807.50   | -0.03%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | MCKESSON CORP                                           | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -44 | NC      | $-302500.00   | -0.06%            |  |  |  | No            |                  1 | On Loan: No      |
| McKesson Corp                                | McKesson Corp                                           | CUSIP: 58155Q103<br>LEI: 549300WZWOM80UCFSF54 | Long             | EC               | CORP              | US        |     11805 | NS      | $9119834.70   | 1.75%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | CVS HEALTH CORP                                         | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -101 | NC      | $-19392.00    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | AGILENT TECHNOLOGIES INC                                | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -70 | NC      | $-19775.00    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | INSMED INC                                              | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -86 | NC      | $-179310.00   | -0.03%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | NATERA INC                                              | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -43 | NC      | $-10965.00    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | BOSTON SCIENTIFIC CORP                                  | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -140 | NC      | $-2800.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| CG oncology Inc                              | CG oncology Inc                                         | CUSIP: 156944100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5223 | NS      | $210382.44    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | DEXCOM INC                                              | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -42 | NC      | $-2310.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | RHYTHM PHARMACEUTICALS INC                              | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -106 | NC      | $-28090.00    | -0.01%            |  |  |  | No            |                  1 | On Loan: No      |
| Danaher Corp                                 | Danaher Corp                                            | CUSIP: 235851102<br>LEI: S4BKK9OTCEWQ3YHPFM11 | Long             | EC               | CORP              | US        |     44278 | NS      | $8778556.28   | 1.69%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | GUARDANT HEALTH INC                                     | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -71 | NC      | $-31240.00    | -0.01%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | MEDTRONIC PLC                                           | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | IE        |       -69 | NC      | $-15352.50    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Regeneron Pharmaceuticals Inc                | Regeneron Pharmaceuticals Inc                           | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |      8927 | NS      | $5019384.29   | 0.96%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | LABCORP HOLDINGS INC                                    | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |        -5 | NC      | $-1950.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | MERCK + CO INC                                          | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -60 | NC      | $-7920.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Summit Therapeutics Inc                      | Summit Therapeutics Inc                                 | CUSIP: 86627T108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     18168 | NS      | $375350.88    | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| EXO IMAGING INC                              | EXO IMAGING INC                                         | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     47496 | NS      | $35147.33     | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Options Clearing Corp.                       | AMGEN INC                                               | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -127 | NC      | $-125095.00   | -0.02%            |  |  |  | No            |                  1 | On Loan: No      |
| REGENXBIO Inc                                | REGENXBIO Inc                                           | CUSIP: 75901B107<br>LEI: 549300EOES47LATSET33 | Long             | EC               | CORP              | US        |     18875 | NS      | $182143.75    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Glaukos Corp                                 | Glaukos Corp                                            | CUSIP: 377322102<br>LEI: 5299004JA1LHE21M6T14 | Long             | EC               | CORP              | US        |      7815 | NS      | $637313.25    | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| SUSQUEHANNA FINANCIAL GROUP LLLP             | BEAM US FLEX                                            | CUSIP: 000000000<br>LEI: 549300E8QX0ZMRDC2M81 | N/A              | DE               |  | US        |       -26 | NC      | $-11784.68    | -0.00%            |  |  |  | No            |                  2 | On Loan: No      |
| Mettler-Toledo International Inc             | Mettler-Toledo International Inc                        | CUSIP: 592688105<br>LEI: 5493000BD5GJNUDIUG10 | Long             | EC               | CORP              | US        |       870 | NS      | $1068020.70   | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| AFFERENT PHARMACEUTICAL                      | AFFERENT PHARMACEUTICAL                                 | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    190160 | NS      | $1.90         | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Teva Pharmaceutical Industries Ltd           | Teva Pharmaceutical Industries Ltd                      | CUSIP: 881624209<br>LEI: 549300BAFGM4RC74ZJ94 | Long             | EC               | CORP              | IL        |    243163 | NS      | $4911892.60   | 0.94%             |  |  |  | No            |                  1 | On Loan: No      |
| BRIDGEBIO ONCOLOGY THERAPEUTICS INC          | BRIDGEBIO ONCOLOGY THERAPEUTICS INC                     | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     15582 | NS      | $180439.56    | 0.03%             |  |  |  | Yes           |                  2 | On Loan: No      |
| Options Clearing Corp.                       | AGILENT TECHNOLOGIES INC                                | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -70 | NC      | $-7350.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Alkermes PLC                                 | Alkermes PLC                                            | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | IE        |     12700 | NS      | $381000.00    | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Elanco Animal Health Inc                     | Elanco Animal Health Inc                                | CUSIP: 28414H103<br>LEI: 549300SHPNDCE059M934 | Long             | EC               | CORP              | US        |     42100 | NS      | $847894.00    | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Merck & Co Inc                               | Merck & Co Inc                                          | CUSIP: 58933Y105<br>LEI: 4YV9Y5M8S0BRK1RP0397 | Long             | EC               | CORP              | US        |     88682 | NS      | $7443080.26   | 1.43%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | ABBVIE INC                                              | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -156 | NC      | $-109590.00   | -0.02%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | ALKERMES PLC                                            | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | IE        |       -48 | NC      | $-8280.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Quest Diagnostics Inc                        | Quest Diagnostics Inc                                   | CUSIP: 74834L100<br>LEI: 8MCWUBXQ0WE04KMXBX50 | Long             | EC               | CORP              | US        |     24219 | NS      | $4615657.02   | 0.89%             |  |  |  | No            |                  1 | On Loan: No      |
| STERIS PLC                                   | STERIS PLC                                              | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | IE        |      6027 | NS      | $1491320.88   | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Scholar Rock Holding Corp                    | Scholar Rock Holding Corp                               | CUSIP: 80706P103<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |     14670 | NS      | $546310.80    | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| West Pharmaceutical Services Inc             | West Pharmaceutical Services Inc                        | CUSIP: 955306105<br>LEI: 5493007NKRGM1RJQ1P16 | Long             | EC               | CORP              | US        |     10207 | NS      | $2677602.31   | 0.51%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC Therapeutics Inc                         | PTC Therapeutics Inc                                    | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |     12726 | NS      | $780994.62    | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| KARTOS THERAPEUTICS INC                      | KARTOS THERAPEUTICS INC                                 | CUSIP: 000000000<br>LEI: N/A                  | Long             | STIV             | CORP              | US        |     85817 | NS      | $487440.56    | 0.09%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Waters Corp                                  | Waters Corp                                             | CUSIP: 941848103<br>LEI: 5T547R1474YC9HOD8Q74 | Long             | EC               | CORP              | US        |     10495 | NS      | $3146505.95   | 0.60%             |  |  |  | No            |                  1 | On Loan: No      |
| Eli Lilly & Co                               | Eli Lilly & Co                                          | CUSIP: 532457108<br>LEI: FRDRIPF3EKNDJ2CQJL29 | Long             | EC               | CORP              | US        |     53254 | NS      | $40632802.00  | 7.81%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | DEXCOM INC                                              | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -50 | NC      | $-2500.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | ELEVANCE HEALTH INC                                     | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -32 | NC      | $-16000.00    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | JOHNSON + JOHNSON                                       | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -417 | NC      | $-237690.00   | -0.05%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | METTLER-TOLEDO INTERNATIONAL I                          | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |        -2 | NC      | $-955.00      | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | JOHNSON + JOHNSON                                       | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |      -460 | NC      | $-324300.00   | -0.06%            |  |  |  | No            |                  1 | On Loan: No      |
| SUSQUEHANNA FINANCIAL GROUP LLLP             | IONS US FLEX                                            | CUSIP: 000000000<br>LEI: 549300E8QX0ZMRDC2M81 | N/A              | DE               |  | US        |       -58 | NC      | $-22623.13    | -0.00%            |  |  |  | No            |                  2 | On Loan: No      |
| 4D Molecular Therapeutics Inc                | 4D Molecular Therapeutics Inc                           | CUSIP: 35104E100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     11778 | NS      | $102350.82    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | NEUROCRINE BIOSCIENCES INC                              | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -19 | NC      | $-13870.00    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| JANE STREET EXECUTION SERVICES, LLC          | WVE US FLEX                                             | CUSIP: 000000000<br>LEI: 549300HXJLXCPDWAH070 | N/A              | DE               |  | US        |       -55 | NC      | $-1054.85     | -0.00%            |  |  |  | No            |                  2 | On Loan: No      |
| Roivant Sciences Ltd                         | Roivant Sciences Ltd                                    | CUSIP: 000000000<br>LEI: 549300DL466NY5J6U724 | Long             | EC               | CORP              | BM        |     42251 | NS      | $639257.63    | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | GE HEALTHCARE TECHNOLOGIES INC                          | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -38 | NC      | $-5890.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| IDEXX Laboratories Inc                       | IDEXX Laboratories Inc                                  | CUSIP: 45168D104<br>LEI: OGMTXK0LUU1HKV2P0J84 | Long             | EC               | CORP              | US        |      6922 | NS      | $4422396.58   | 0.85%             |  |  |  | No            |                  1 | On Loan: No      |
| Hologic Inc                                  | Hologic Inc                                             | CUSIP: 436440101<br>LEI: 549300DYP6F5ZJL0LB74 | Long             | EC               | CORP              | US        |     12498 | NS      | $843490.02    | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| JANE STREET EXECUTION SERVICES, LLC          | INCY.FLEX                                               | CUSIP: 000000000<br>LEI: 549300HXJLXCPDWAH070 | N/A              | DE               |  | US        |       -55 | NC      | $-19371.94    | -0.00%            |  |  |  | No            |                  2 | On Loan: No      |
| Bristol-Myers Squibb Co                      | Bristol-Myers Squibb Co                                 | CUSIP: 110122108<br>LEI: HLYYNH7UQUORYSJQCN42 | Long             | EC               | CORP              | US        |     97755 | NS      | $4408750.50   | 0.85%             |  |  |  | No            |                  1 | On Loan: No      |
| Options Clearing Corp.                       | ELI LILLY + CO                                          | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -58 | NC      | $-242585.00   | -0.05%            |  |  |  | No            |                  1 | On Loan: No      |
| INSITRO INC                                  | INSITRO INC                                             | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     30616 | NS      | $280442.56    | 0.05%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Allogene Therapeutics Inc                    | Allogene Therapeutics Inc                               | CUSIP: 019770106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    108101 | NS      | $134045.24    | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Gilead Sciences Inc                          | Gilead Sciences Inc                                     | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |     89782 | NS      | $9965802.00   | 1.92%             |  |  |  | No            |                  1 | On Loan: No      |
| BARCLAYS BANK PLC                            | OCT25 AZN LN C @ 115.2814                               | CUSIP: 000000000<br>LEI: G5GSEF7VJP5I7OUK5573 | N/A              | DE               |  | US        |     -9100 | NC      | $-22672.46    | -0.00%            |  |  |  | No            |                  2 | On Loan: No      |
| SUSQUEHANNA FINANCIAL GROUP LLLP             | IDXX US FLEX                                            | CUSIP: 000000000<br>LEI: 549300E8QX0ZMRDC2M81 | N/A              | DE               |  | US        |       -26 | NC      | $-78874.15    | -0.02%            |  |  |  | No            |                  2 | On Loan: No      |
| Options Clearing Corp.                       | REGENERON PHARMACEUTICALS INC                           | CUSIP: 000000000<br>LEI: 549300CII6SLYGKNHA04 | N/A              | DE               |  | US        |       -16 | NC      | $-4080.00     | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2025-10-29

**Name of Applicant:** BlackRock Health Sciences Trust

**Signature:** Chuck Pulsfort

**Name of Signer:** Chuck Pulsfort

**Title:** Assistant Treasurer