# EDGAR Filing Document

**Accession Number:** 0001793365
**File Stem:** 0001213900-23-010903
**Filing Date:** 2023-2
**Character Count:** 20187
**Document Hash:** db2e4367090e157f1c22de2d5ca8214e
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001213900-23-010903.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001213900-23-010903

**CONFORMED SUBMISSION TYPE**: SC 13G/A

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230213

**GROUP MEMBERS**: VIVO ASIA OPPORTUNITY, LLC

**GROUP MEMBERS**: VIVO OPPORTUNITY, LLC

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Genetron Holdings Limited/ADR
- **CENTRAL INDEX KEY:** 0001793365
- **IRS NUMBER:** 000000000

**FILING VALUES:**
- **FORM TYPE:** SC 13G/A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-91547
- **FILM NUMBER:** 23620465

**BUSINESS ADDRESS:**
- **STREET 1:** 120 BROADWAY
- **STREET 2:** 32ND FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10271
- **BUSINESS PHONE:** 212-238-3128

**MAIL ADDRESS:**
- **STREET 1:** 120 BROADWAY
- **STREET 2:** 32ND FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10271
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Vivo Capital IX, LLC
- **CENTRAL INDEX KEY:** 0001750698
- **IRS NUMBER:** 824768569
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G/A

**BUSINESS ADDRESS:**
- **STREET 1:** 192 LYTTON AVENUE
- **CITY:** PALO ALTO
- **STATE:** CA
- **ZIP:** 94301
- **BUSINESS PHONE:** 6506880818

**MAIL ADDRESS:**
- **STREET 1:** 192 LYTTON AVENUE
- **CITY:** PALO ALTO
- **STATE:** CA
- **ZIP:** 94301

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

---

| |
|:---|
| &nbsp;&nbsp;**SCHEDULE 13G/A** |
| &nbsp;&nbsp; **Under the Securities Exchange Act of 1934** <br> **(Amendment No. 1)\*** |

---

---

| |
|:---|
| **Genetron Holdings Limited** |
| &nbsp;&nbsp;(Name of Issuer) |

---

---

| |
|:---|
| &nbsp;&nbsp;**Ordinary share, par value $0.00002, represented by American Depositary Share** |
| &nbsp;&nbsp;(Title of Class of Securities) |

---

---

| |
|:---|
| &nbsp;&nbsp;**37186H100** |
| &nbsp;&nbsp;(CUSIP Number) |

---

---

| |
|:---|
| &nbsp;&nbsp;**December 31, 2022** |
| &nbsp;&nbsp;(Date of Event which Requires Filing of this Statement) |

---

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

☐ Rule 13d-1(b)

☒ Rule 13d-1(c)

☐ Rule 13d-1(d)

\* The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

---

| | |
|:---|:---|
| &nbsp;&nbsp;CUSIP No. **37186H100** | &nbsp;&nbsp;CUSIP No. **37186H100** |
| &nbsp;&nbsp;**1** | NAMES OF REPORTING PERSONS |
| &nbsp;&nbsp;**1** | &nbsp;&nbsp;**Vivo Capital IX, LLC** |
| &nbsp;&nbsp;**2** | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) |
| &nbsp;&nbsp;**2** | (a) ☒ |
| &nbsp;&nbsp;**2** | &nbsp;&nbsp;(b) ☐ |
| &nbsp;&nbsp;**3** | SEC USE ONLY |
| &nbsp;&nbsp;**3** |  |
| &nbsp;&nbsp;**4** | CITIZENSHIP OR PLACE OF ORGANIZATION |
| &nbsp;&nbsp;**4** | &nbsp;&nbsp;**Delaware** |

---

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**5** | &nbsp;&nbsp;SOLE VOTING POWER |
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**5** | &nbsp;&nbsp;&nbsp;&nbsp;**28574300 <sup>(1)</sup>** |
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**6** | &nbsp;&nbsp;SHARED VOTING POWER |
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**6** | &nbsp;&nbsp;&nbsp;&nbsp;**0** |
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**7** | &nbsp;&nbsp;SOLE DISPOSITIVE POWER |
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**7** | &nbsp;&nbsp;&nbsp;&nbsp;**28574300 <sup>(1)</sup>** |
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**8** | &nbsp;&nbsp;SHARED DISPOSITIVE POWER |
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**8** | &nbsp;&nbsp;&nbsp;&nbsp;**0** |

---

---

| | |
|:---|:---|
| &nbsp;&nbsp;**9** | &nbsp;&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| &nbsp;&nbsp;**9** | &nbsp;&nbsp;**28574300 <sup>(1)</sup>** |
| &nbsp;&nbsp;**10** | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions) |
| &nbsp;&nbsp;**10** | &nbsp;&nbsp;☐ |
| &nbsp;&nbsp;**11** | &nbsp;&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
| &nbsp;&nbsp;**11** | &nbsp;&nbsp;**6.3% <sup>(2)</sup>** |
| &nbsp;&nbsp;**12** | &nbsp;&nbsp;TYPE OF REPORTING PERSON (See Instructions) |
| &nbsp;&nbsp;**12** | &nbsp;&nbsp;&nbsp;**OO** |

---

 

<sup>(1)</sup> The number represents 28,574,300 ordinary shares, par value $0.00002 per share (the "Ordinary Shares") of Genetron Holdings Limited (the "Issuer"), which are represented by 5,714,860 American Depositary Shares ("ADS"). The securities are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the general partner of Vivo Capital Fund IX, L.P.

 

<sup>(2)</sup> Based on 452,807,305 Ordinary Shares issued and outstanding as of December 31, 2021, as reported in the Issuer's annual report on Form 20-F, filed with the Securities and Exchange Commission (the "SEC") on April 29, 2022.

---

| | |
|:---|:---|
| &nbsp;&nbsp;CUSIP No. **37186H100** | &nbsp;&nbsp;CUSIP No. **37186H100** |
| &nbsp;&nbsp;**1** | NAMES OF REPORTING PERSONS |
| &nbsp;&nbsp;**1** | &nbsp;&nbsp;**Vivo Opportunity, LLC** |
| &nbsp;&nbsp;**2** | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) |
| &nbsp;&nbsp;**2** | (a) ☒ |
| &nbsp;&nbsp;**2** | &nbsp;&nbsp;(b) ☐ |
| &nbsp;&nbsp;**3** | SEC USE ONLY |
| &nbsp;&nbsp;**3** |  |
| &nbsp;&nbsp;**4** | CITIZENSHIP OR PLACE OF ORGANIZATION |
| &nbsp;&nbsp;**4** | &nbsp;&nbsp;**Delaware** |

---

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**5** | &nbsp;&nbsp;SOLE VOTING POWER |
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**5** | &nbsp;&nbsp;&nbsp;&nbsp;**3125000 <sup>(1)</sup>** |
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**6** | &nbsp;&nbsp;SHARED VOTING POWER |
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**6** | &nbsp;&nbsp;&nbsp;&nbsp;**0** |
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**7** | &nbsp;&nbsp;SOLE DISPOSITIVE POWER |
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**7** | &nbsp;&nbsp;&nbsp;&nbsp;**3125000 <sup>(1)</sup>** |
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**8** | &nbsp;&nbsp;SHARED DISPOSITIVE POWER |
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**8** | &nbsp;&nbsp;&nbsp;&nbsp;**0** |

---

---

| | |
|:---|:---|
| &nbsp;&nbsp;**9** | &nbsp;&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| &nbsp;&nbsp;**9** | &nbsp;&nbsp;**3125000 <sup>(1)</sup>** |
| &nbsp;&nbsp;**10** | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions) |
| &nbsp;&nbsp;**10** | &nbsp;&nbsp;☐ |
| &nbsp;&nbsp;**11** | &nbsp;&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
| &nbsp;&nbsp;**11** | &nbsp;&nbsp;**0.7% <sup>(2)</sup>** |
| &nbsp;&nbsp;**12** | &nbsp;&nbsp;TYPE OF REPORTING PERSON (See Instructions) |
| &nbsp;&nbsp;**12** | &nbsp;&nbsp;&nbsp;**OO** |

---

<sup>(1)</sup> The number represents 3,125,000 Ordinary Shares of the Issuer, which are represented by 625,000 ADS. The securities are held of record by Vivo Opportunity Fund Holdings, L.P. Vivo Opportunity, LLC is the general partner of Vivo Opportunity Fund Holdings, L.P.

<sup>(2)</sup> Based on 452,807,305 Ordinary Shares issued and outstanding as of December 31, 2021, as reported in the Issuer's annual report on Form 20-F, filed with the SEC on April 29, 2022.

---

| | |
|:---|:---|
| &nbsp;&nbsp;CUSIP No. **37186H100** | &nbsp;&nbsp;CUSIP No. **37186H100** |
| &nbsp;&nbsp;**1** | NAMES OF REPORTING PERSONS |
| &nbsp;&nbsp;**1** | &nbsp;&nbsp;**Vivo Asia Opportunity, LLC** |
| &nbsp;&nbsp;**2** | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) |
| &nbsp;&nbsp;**2** | (a) ☒ |
| &nbsp;&nbsp;**2** | &nbsp;&nbsp;(b) ☐ |
| &nbsp;&nbsp;**3** | SEC USE ONLY |
| &nbsp;&nbsp;**3** |  |
| &nbsp;&nbsp;**4** | CITIZENSHIP OR PLACE OF ORGANIZATION |
| &nbsp;&nbsp;**4** | &nbsp;&nbsp;**Cayman Islands** |

---

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**5** | &nbsp;&nbsp;SOLE VOTING POWER |
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**5** | &nbsp;&nbsp;&nbsp;&nbsp;**8921570 <sup>(1)</sup>** |
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**6** | &nbsp;&nbsp;SHARED VOTING POWER |
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**6** | &nbsp;&nbsp;&nbsp;&nbsp;**0** |
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**7** | &nbsp;&nbsp;SOLE DISPOSITIVE POWER |
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**7** | &nbsp;&nbsp;&nbsp;&nbsp;**8921570 <sup>(1)</sup>** |
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**8** | &nbsp;&nbsp;SHARED DISPOSITIVE POWER |
| &nbsp;&nbsp;NUMBER OF <br> SHARES<br> BENEFICIALLY<br> OWNED BY EACH <br> REPORTING PERSON<br> WITH | &nbsp;&nbsp;**8** | &nbsp;&nbsp;&nbsp;&nbsp;**0** |

---

---

| | |
|:---|:---|
| &nbsp;&nbsp;**9** | &nbsp;&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| &nbsp;&nbsp;**9** | &nbsp;&nbsp;**8921570 <sup>(1)</sup>** |
| &nbsp;&nbsp;**10** | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions) |
| &nbsp;&nbsp;**10** | &nbsp;&nbsp;☐ |
| &nbsp;&nbsp;**11** | &nbsp;&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
| &nbsp;&nbsp;**11** | &nbsp;&nbsp;**2.0% <sup>(2)</sup>** |
| &nbsp;&nbsp;**12** | &nbsp;&nbsp;TYPE OF REPORTING PERSON (See Instructions) |
| &nbsp;&nbsp;**12** | &nbsp;&nbsp;&nbsp;**OO** |

---

 

<sup>(1)</sup> The number represents 8,921,570 Ordinary Shares of the Issuer, which are represented by 1,784,314 ADS. The securities are held of record by Vivo Asia Opportunity Fund Holdings, L.P. Vivo Asia Opportunity, LLC is the general partner of Vivo Asia Opportunity Fund Holdings, L.P.

<sup>(2)</sup> Based on 452,807,305 Ordinary Shares issued and outstanding as of December 31, 2021, as reported in the Issuer's annual report on Form 20-F, filed with the SEC on April 29, 2022.

Item 1. (a) Name of Issuer:

Genetron Holdings Limited

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Address of Issuer's Principal Executive Offices:

1-2/F, Building 11, Zone 1, No.8 Life Science Parkway

Changping District, Beijing, 102206, People's Republic of China

Item 2. (a) Name of Person Filing:

This Amendment No. 1 to Schedule 13G is filed jointly by Vivo Capital IX, LLC, Vivo Opportunity, LLC and Vivo Asia Opportunity, LLC.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Address of Principal Business Office or, if None, Residence:

192 Lytton Avenue, Palo Alto, CA 94301

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Citizenship:

Vivo Capital IX, LLC is a Delaware limited liability company.

Vivo Opportunity, LLC is a Delaware limited liability company.

Vivo Asia Opportunity, LLC is a Cayman Islands limited liability company.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) Title of Class of Securities:

Ordinary Shares, par value $0.00002, represented by American Depositary Shares, each of which represents five Ordinary Shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) CUSIP Number:

37186H100

Item 3. If This Statement is Filed Pursuant to §§ 240.13d-1(b), or 240.13d-2(b) or (c), Check Whether the Person Filing is a:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) ☐ Broker or dealer registered under Section 15 of the Act.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ☐ Bank as defined in Section 3(a)(6) of the Act.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) ☐ Insurance company as defined in Section 3(a)(19) of the
Act.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) ☐ Investment company registered under Section 8 of the
Investment Company Act of 1940.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) ☐ An investment adviser in accordance with §
240.13d-1(b)(1)(ii)(E) ;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) ☐ An employee benefit plan or endowment fund in accordance
with § 240.13d-1 (b)(1)(ii)(F);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) ☐ A parent holding company or control person in accordance
with § 240.13d-1 (b)(l)(ii)(G);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) ☐ A savings association as defined in Section 3(b) of the
Federal Deposit Insurance Act;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) ☐ A church plan that is excluded from the definition of
an investment company under Section 3(c)(14) of the Investment Company Act;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(j) ☐ A non-U.S. institution in accordance with §
240.13d-1 (b)(1)(ii)(J);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(k) ☐ Group, in accordance with §
240.13d-1 (b)(l)(ii)(K).

If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1(ii)(j), please specify the type of institution: ________________

Not Applicable.

Item 4. Ownership.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Amount beneficially owned:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) Vivo
Capital IX, LLC

The 28,574,300 Ordinary Shares, represented by 5,714,860 ADSs, are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the general partner of Vivo Capital Fund IX, L.P. The voting members of Vivo Capital IX, LLC are Frank Kung, Edgar Engleman, Shan Fu, Hongbo Lu, Mahendra Shah, Jack Nielsen and Michael Chang, none of whom has individual voting or investment power with respect to these shares and each of whom disclaims beneficial ownership of such shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) Vivo
Opportunity, LLC

The 3,125,000 Ordinary Shares, represented by 625,000 ADSs, are held of record by Vivo Opportunity Fund Holdings, L.P. Vivo Opportunity, LLC is the general partner of Vivo Opportunity Fund Holdings, L.P. The voting members of Vivo Opportunity, LLC are Gaurav Aggarwal, Hongbo Lu, Frank Kung, Michael Chang and Kevin Dai, none of whom has individual voting or investment power with respect to these shares and each of whom disclaims beneficial ownership of such shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3) Vivo
Asia Opportunity, LLC

The 8,921,570 Ordinary Shares, represented by 1,784,314 ADS, are held of record by Vivo Asia Opportunity Fund Holdings, L.P. Vivo Asia Opportunity, LLC is the general partner of Vivo Asia Opportunity Fund Holdings, L.P. The voting members of Vivo Asia Opportunity, LLC are Hongbo Lu, Shan Fu and Frank Kung, none of whom has individual voting or investment power with respect to these shares and each of whom disclaims beneficial ownership of such shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Percent of class:

Vivo Capital IX, LLC: 6.3%

Vivo Opportunity, LLC: 0.7%

Vivo Asia Opportunity, LLC: 2.0%

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Number of shares as to which such person has:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) Sole power to vote or to direct the vote:

Vivo Capital IX, LLC: 28,574,300 Ordinary Shares, represented by 5,714,860 ADSs

Vivo Opportunity, LLC: 3,125,000 Ordinary Shares, represented by 625,000 ADSs

Vivo Asia Opportunity, LLC: 8,921,570 Ordinary Shares, represented by 1,784,314 ADSs

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) Shared power to vote or to direct the vote: 0

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) Sole power to dispose or to direct the disposition of:

Vivo Capital IX, LLC: 28,574,300 Ordinary Shares, represented by 5,714,860 ADSs

Vivo Opportunity, LLC: 3,125,000 Ordinary Shares, represented by 625,000 ADSs

Vivo Asia Opportunity, LLC: 8,921,570 Ordinary Shares, represented by 1,784,314 ADSs

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) Shared power to dispose of or to direct the disposition of: 0

Item 5. Ownership of Five Percent or Less of a Class.

Not Applicable.

Item 6. Ownership of More than Five Percent on Behalf of Another Person.

Not Applicable.

Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.

Not Applicable.

Item 8. Identification and Classification of Members of the Group.

Not applicable.

Item 9. Notice of Dissolution of Group.

Not applicable.

Item 10. Certifications.

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under §240.14a11.

**SIGNATURE**

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

---

| |
|:---|
| **Vivo Capital IX, LLC** |
| February 13, 2023 |
| (Date) |
| /s/ Frank Kung |
| (Signature) |
| Managing Member |
| (Title) |
| **Vivo Opportunity, LLC** |
| February 13, 2023 |
| (Date) |
| /s/ Gaurav Aggarwal |
| (Signature) |
| Managing Member |
| (Title) |
| **Vivo Asia Opportunity, LLC** |
| February 13, 2023 |
| (Date) |
| /s/ Hongbo Lu |
| (Signature) |
| Managing Member |
| (Title) |

---