# EDGAR Filing Document

**Accession Number:** 0001840706
**File Stem:** 0000950103-25-008700
**Filing Date:** 2025-7
**Character Count:** 33729
**Document Hash:** 55fadf1350386b92495e92cd8d69dba6
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000950103-25-008700.hdr.sgml**: 20250711

**ACCESSION NUMBER**: 0000950103-25-008700

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 7

**FILED AS OF DATE**: 20250711

**DATE AS OF CHANGE**: 20250711

**EFFECTIVENESS DATE**: 20250711

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** SOPHiA GENETICS SA
- **CENTRAL INDEX KEY:** 0001840706
- **STANDARD INDUSTRIAL CLASSIFICATION:** SERVICES-COMPUTER PROCESSING & DATA PREPARATION [7374]
- **ORGANIZATION NAME:** 06 Technology
- **EIN:** 000000000
- **STATE OF INCORPORATION:** V8
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-288625
- **FILM NUMBER:** 251117564

**BUSINESS ADDRESS:**
- **STREET 1:** LA PIECE, CH-1180
- **CITY:** ROLLE
- **STATE:** V8
- **ZIP:** 00000
- **BUSINESS PHONE:** 41 21 694 10 60

**MAIL ADDRESS:**
- **STREET 1:** LA PIECE, CH-1180
- **CITY:** ROLLE
- **STATE:** V8
- **ZIP:** 00000

**As filed with the Securities and Exchange Commission on July 11, 2025**

**Registration No. 333-__________**

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**FORM S-8**

**REGISTRATION STATEMENT UNDER**

**THE SECURITIES ACT OF 1933**

**SOPHiA GENETICS SA**

(Exact name of registrant as specified in its charter)

---

| | |
|:---|:---|
| **Switzerland** | **Not Applicable** |
| (State or other jurisdiction of<br> incorporation or organization) | (I.R.S. Employer<br> Identification No.) |

---

**La Pièce 12, CH-1180 Rolle, Switzerland**

(Address of Principal Executive Offices)

**SOPHiA GENETICS SA 2021 Equity Incentive Plan** 

(Full title of the plan)

**SOPHiA GENETICS, Inc.**

**401 Park Drive, Suite 505**

**Boston, MA 02215**

(Name and Address of Agent For Service)

**(617) 982-1210**

(Telephone number, Including Area Code, of Agent For Service)

***Copies of all communications, including all communications sent to the agent for service, should be sent to:***

**Kyoko Takahashi Lin**

**Davis Polk & Wardwell LLP**

**450 Lexington Avenue**

**New York, NY 10017**

**(212) 450-4000**

**Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.**

---

| | |
|:---|:---|
| **Large accelerated filer** □ | **Accelerated filer** ⌧ |
| **Non-accelerated filer** □ | **Smaller reporting company** □ |

---

---

| | |
|:---|:---|
| **(Do not check if a smaller reporting company)** | **Emerging Growth Company** ⌧ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. □

**PART I**

**INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS**

Pursuant to General Instruction E to Form S-8, SOPHiA GENETICS SA (the "**Registrant**") is filing this Registration Statement on Form S-8 (this "**Registration Statement**") with the U.S. Securities and Exchange Commission (the "**Commission**") to register 15,693,055 additional ordinary shares, par value CHF 0.05 per share, of the Registrant (the "**Shares**"), for issuance under the Registrant's 2021 Equity Incentive Plan. This Registration Statement hereby incorporates by reference the contents of the Registrant's registration statements on Form S-8 filed with the Commission on July 23, 2021 (Registration No. 333-258121). In accordance with the instructional note to Part I of Form S-8 as promulgated by the Commission, the information specified by Part I of Form S-8 has been omitted from this Registration Statement.

**PART II**

**INFORMATION REQUIRED IN THE REGISTRATION STATEMENT**

**Item 3. Incorporation of Documents by Reference.**

The following documents are incorporated herein by reference:

&nbsp;&nbsp;&nbsp;&nbsp;(a) The latest Registrant's Form 20-F filed with the Commission on March 04, 2025 (the "**Form 20-F**") pursuant
to Section 13(a) or 15(d) of the Exchange Act (the "**Exchange Act** "), which contains the Registrant's audited financial
statements for the latest fiscal year for which such statements have been filed (File No. 001-40627);

&nbsp;&nbsp;&nbsp;&nbsp;(b) The Registrant's Current Report on Form 6-K, filed with the SEC on May 6, 2025 (other than Exhibit 99.3 thereto) (File No. 001-40627);
and

&nbsp;&nbsp;&nbsp;&nbsp;(c) The description of the Registrant's share capital which is included as Exhibit 2.1 to the Form 20-F, including any amendment
or supplements thereto.

In addition, all documents subsequently filed by the Registrant with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective amendment to this Registration Statement which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, including any Reports of Foreign Private Issuers on Form 6-K submitted during such period (or portion thereof) that is identified in such form as being incorporated by reference into this Registration Statement, shall be deemed to be incorporated by reference in this Registration Statement and to be a part hereof from the date of the filing of such documents. The Registrant is not incorporating by reference any documents or portions thereof, whether specifically listed above or filed in the future, that are not deemed "filed" with the Commission.

Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein, (or in any other subsequently filed document which also is incorporated or deemed to be incorporated by reference herein), modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.

**Item 8. Exhibits.**

---

| | |
|:---|:---|
| Exhibit Number |  |
| [<u>4</u>](https://www.sec.gov/Archives/edgar/data/1840706/000184070625000021/amendedarticlesofassocia.htm) | [Amended Articles of Association of SOPHiA GENETICS SA (incorporated herein by reference to Exhibit 99.1 to the Registrant's Form 6-K, filed on June 18, 2025)](https://www.sec.gov/Archives/edgar/data/1840706/000184070625000021/amendedarticlesofassocia.htm) |
| [<u>5</u>](dp231391_ex5.htm) | [<u>Opinion of Niederer Kraft Frey Ltd., Swiss counsel of SOPHiA GENETICS SA (filed herewith)</u>](dp231391_ex5.htm) |
| [<u>23.1</u>](dp231391_ex2301.htm) | [<u>Consent of PricewaterhouseCoopers SA, independent registered public accounting firm (filed herewith)</u>](dp231391_ex2301.htm) |
| [<u>23.2</u>](dp231391_ex5.htm) | [<u>Consent of Niederer Kraft Frey Ltd.,Swiss counsel of SOPHiA GENETICS SA (included in Exhibit 5)</u>](dp231391_ex5.htm) |
| [24](#a_001) | [<u>Powers of Attorney (included in the signature pages hereto)</u>](#a_001) |
| [99.1](https://www.sec.gov/Archives/edgar/data/1840706/000119312521207629/d101766dex1013.htm) | [SOPHiA GENETICS SA 2021 Equity Incentive Plan (incorporated herein by reference to Exhibit 10.13 to the Registrant's Registration Statement on Form F-1, filed on July 2, 2021)](https://www.sec.gov/Archives/edgar/data/1840706/000119312521207629/d101766dex1013.htm) |
| [<u>107</u>](dp231391_exfilingfees.htm) | [<u>Filing Fee Table (filed herewith)</u>](dp231391_exfilingfees.htm) |

---

**SIGNATURES**

Pursuant to the requirements of the Securities Act of 1933, as amended (the "**Securities Act**"), the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing this Registration Statement and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the municipality of Rolle, Switzerland on July 11, 2025.

---

| | |
|:---|:---|
| SOPHiA GENETICS SA | SOPHiA GENETICS SA |
| By: | /s/ Ross Muken |
| Name: | Ross Muken |
| Title: | President |

---

**POWER OF ATTORNEY**

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Jurgi Camblong, Ross Muken and Daan van Well and each of them, individually, as his or her true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, in connection with this registration statement, including to sign in the name and on behalf of the undersigned, this Registration Statement and any and all amendments thereto, including post-effective amendments and registrations filed pursuant to Rule 462 under the Securities Act, as amended, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the U.S. Securities and Exchange Commission, granting unto each such attorney-in-fact and agent full power and authority to do and perform each and every act in person, hereby ratifying and confirming all that each said attorney-in-fact and agent, or his or her substitutes, may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

---

| | | |
|:---|:---|:---|
| **<u>Signature</u>** | **<u>Title</u>** | **<u>Date</u>** |
| /s/ Jurgi Camblong | Chief Executive Officer and Director | July 11, 2025 |
| Jurgi Camblong | (Principal Executive Officer) |  |
| /s/ George Cardoza | Chief Financial Officer | July 11, 2025 |
| George Cardoza | (Principal Financial and Accounting Officer) |  |
| /s/ Troy Cox |  | July 11, 2025 |
| Troy Cox | Chairman of the Board of Directors |  |
| /s/ Tomer Berkovitz |  | July 11, 2025 |
| Tomer Berkovitz | Director |  |
| /s/ Kathy Hibbs |  | July 11, 2025 |
| Kathy Hibbs | Director |  |
| /s/ Didier Hirsch |  | July 11, 2025 |
| Didier Hirsch | Director |  |
| /s/ Vincent Ossipow |  | July 11, 2025 |
| Vincent Ossipow | Director |  |
| /s/ Jean-Michel Cosséry |  | July 11, 2025 |
| Jean-Michel Cosséry | Director |  |
| /s/ Ross Muken |  | July 11, 2025 |
| Ross Muken | President, Authorized Representative in the United States |  |

---

## Ex-5

**Exhibit 5 and Exhibit 23.2**

![](image_002.jpg)

To:

SOPHiA GENETICS SA

La Pièce 12

1180 Rolle Switzerland

July 11, 2025

**Form S-8 Registration Statement**

Dear Sirs,

We have acted as Swiss counsel to SOPHiA GENETICS SA, a corporation (*société anonyme*) incorporated under the laws of Switzerland (the "**Company**") in connection with its filing of a registration statement on Form S-8 (the "**Registration Statement**") with the United States Securities and Exchange Commission (the "**SEC**") on the date hereof in respect of the issuance of 15,693,055 ordinary shares with a nominal value of CHF 0.05 each (the "**S-8 Shares**") under the Company's 2021 Equity Incentive Plan (the "**Plan**").

As such legal counsel, we are rendering this legal opinion (the "**Legal Opinion**") in respect of certain matters relating to Swiss law.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**I.** **DOCUMENTS REVIEWED** 

For the purpose of this Legal Opinion we have reviewed and relied on the following documents only (collectively, the "**Documents**"):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) a PDF copy of the Registration Statement;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) a PDF copy of the Plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) a PDF copy of a certified excerpt from the Commercial Register of the Canton of Vaud,
Switzerland regarding the Company dated 2 July 2025 (the "**RC Excerpt** ");

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) a PDF copy of the articles of association (*statuts*) of the Company in their
version of 18 June 2025 and certified as of 4 July 2025, referred to on the RC Excerpt as being the most recent articles of association
of the Company filed with the Commercial Register of the Canton of Vaud, Switzerland (the "**Articles of Association** ");

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) (a) a PDF copy of the minutes of the Company's extraordinary general meeting of the
shareholders held on 29 June 2021 regarding, inter alia, the creation of a conditional share capital reserved for employee participation
and the approval of the Plan, (b) a PDF copy of the minutes of the Company's annual general meeting of the shareholders held on 15 June
2022 regarding the amendment of the conditional share capital, (c) a PDF

![](image_001.jpg)

![](image_004.jpg)

copy of the minutes of the Company's annual general meeting of the shareholders held on 26 June 2023 regarding the amendment of the conditional share capital, (d) a PDF copy of the minutes of the Company's annual general meeting of the shareholders held on 24 June 2024 regarding the amendment of the conditional share capital and (e) a PDF copy of the minutes of the Company's annual general meeting of the shareholders held on 18 June 2025 regarding the amendment of the conditional share capital (collectively, the "**AGM/EGM Resolutions**"); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) a PDF copy of the signed circular resolution of the board of directors of the Company
dated 4 July 2025 regarding, inter alia, the filing of the Registration Statement (the "**Board Resolution** ").

We have not reviewed any other documents, nor have we made any independent investigation of facts other than as explicitly stated herein.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**II.** **SCOPE AND ASSUMPTIONS** 

The opinions given in this Legal Opinion relate only to the laws of Switzerland as in force at the date hereof. We express no opinion on the laws of any other jurisdiction. The opinions given in this Legal Opinion are strictly limited to the matters stated in section III and do not extend to any other matters, agreements or other document referred to in any of the Documents.

The opinions given herein are made on the basis of the following assumptions:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) all documents supplied to us as copies, facsimile copies or via email are authentic and
complete and conform to the original documents;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) all signatures on the documents submitted to us are genuine and authentic;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) where we relied upon Documents executed by or on behalf of parties (other than the
Company), such parties (a) were and are duly incorporated, organized and validly existing and in good standing (if applicable) under all
applicable laws, (b) had and have the power and capacity, corporate or otherwise, to enter into and perform their obligations thereunder,
(c) had and have due authorization by all requisite action, corporate or otherwise, to execute and deliver such Documents, and (d) had
and have duly executed and delivered the Documents with binding effect;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) the Documents and all related agreements, deeds and other relevant documents have been
validly authorized, executed and delivered by, and constitute legal, valid, binding and enforceable obligations of the parties thereto
under any laws applicable to each of them (other than the Company under the laws of Switzerland);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) the parties to the Documents have not entered into any other agreements or arrangements
that would impair the capacity, power and authority of such parties to

![](image_004.jpg)

execute and deliver, and perform their respective obligations under the Documents to which they are a party;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) the Registration Statement has been or will be duly filed by the Company and authorized
by all necessary actions under all applicable laws;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) prior to the issuance of any S-8 Shares, the board of directors of the Company will have
duly authorized the issuance of any rights to receive S-8 Shares and will have validly excluded the pre-emptive rights of the existing
shareholders for purposes of the offering of S-8 Shares under the Plan as contemplated in the Registration Statement, and such authorization
and exclusion will not have been amended and will be in full force and effect until the issuance of all S-8 Shares;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(viii) to the extent any documents have to be executed or any obligations have to be performed
under any applicable law other than the laws of Switzerland or in any jurisdiction outside Switzerland, such execution or performance
has not been and will not be illegal, invalid or unenforceable by virtue of the laws of such jurisdiction;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ix) all written resolutions, regulations, powers of attorney and other Documents examined
remain in full force and effect as of the date hereof and have not been amended, revoked, rescinded, terminated or affected by any action
subsequent to their execution or taking, and the terms of each such document examined reflect the true intent and the entire agreement
of the parties thereto in respect of its subject matter;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(x) all parties entered into the Documents to which they are a party for *bona fide* commercial reasons and at arm's length terms, and none of the directors or officers of any party has or had a conflict of interest with
such party in respect of the Documents that would preclude such director or officer from validly representing (or granting a power of
attorney in respect of the Documents for) the respective party;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(xi) other than expressly opined upon in section III and to the
extent relevant for this Legal Opinion, all factual statements and certifications made and representations and warranties given as well
as any and all information contained in the Documents are and at all relevant times will be true, accurate, complete and up-to-date;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(xii) as of the date hereof, none of the parties to the Documents is insolvent or over-indebted
(in the case of Swiss companies. within the meaning of articles 725 et seq. of the Swiss Code of Obligations ()"**CO** ")),
has passed a resolution for its dissolution, winding-up or liquidation, no petition has been presented or order made by a court or other
competent authority for the dissolution, winding-up, liquidation, bankruptcy, moratorium, composition with creditors or administration
of a party or for the ordering of measures in case of a danger of insolvency pursuant to articles 25 et seq. of the Swiss Federal Act
on Banks and Savings Institutions, and no receiver, trustee in bankruptcy, administrator or similar officer has been appointed in relation
to either of the parties or any of their assets or revenues;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(xiii) there is and there will be no court or administrative order which would prevent the
entry into, or the performance of the transactions contemplated by, the Registration Statement;

![](image_004.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(xiv) the S-8 Shares will be listed on NASDAQ in accordance with applicable laws and regulations
and will not be listed or admitted to trading on any trading venue (exchange or multilateral trading facility) in Switzerland;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(xv) all exercise notices with respect to the S-8 Shares will be duly delivered in accordance
with Swiss law, the Plan and any applicable contractual arrangements;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(xvi) to the extent any authorizations, approvals, consents, licenses, exemptions or other
requirements of governmental authorities (collectively, "**Authorizations**") are to be obtained outside of Switzerland for
the legality, validity and enforceability of the filing of the Registration Statement or any other activities carried out in view of or
in connection with the performance of the obligations expressed to be undertaken by the Company in connection therewith, such Authorizations
have been obtained or fulfilled in due time, and are and will remain in full force and effect at all relevant times and any related conditions
to which the parties thereto are subject to have been satisfied;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(xvii) the resolutions reflected in the Board Resolutions and the AGM/EGM Resolutions (a) have
been resolved in meetings duly convened and otherwise in the manner set forth therein, (b) are a true record of the proceedings described
therein and have not been rescinded or amended, and (c) are in full force and effect;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(xviii) the Articles of Association and the RC Excerpt are unchanged, correct, complete and
up- to-date and in full force and effect as of the date hereof and no changes have been made which should have been or should be reflected
in the Articles of Association or the RC Excerpt as of the date hereof; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(xix) (a) there are no facts, circumstances or events not reflected in the Documents that
would be relevant to our opinions expressed herein, and (b) none of the opinions expressed herein will be affected by the laws (including,
but not limited to, the public policy) of any jurisdiction other than Switzerland.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**III.** **OPINIONS** 

Based upon the foregoing, in reliance thereon, and subject to the limitations and assumptions set out above in section II and the qualifications set out below in section IV, we are of the following opinion:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. The Company is a corporation (*société anonyme*) duly incorporated
and is validly existing under the laws of Switzerland, and has the necessary corporate power and authority to conduct its business as
described in the Articles of Association.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. Provided the issue price for the S-8 Shares has been fully paid-in by way of cash or
set- off in accordance with the requirements of the Swiss Code of Obligations (CO) and entered into the Company's book of uncertificated
securities, the S-8 Shares to be issued from the Company's share capital are or will be validly issued, fully paid-in and non- assessable.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**IV.** **QUALIFICATIONS** 

![](image_004.jpg)

This Legal Opinion is subject to the following qualifications:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) This Legal Opinion is subject to the substantive laws of Switzerland as in effect
and as interpreted at the date hereof.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) The opinions set out above are subject to applicable bankruptcy, insolvency, reorganisation
or similar laws affecting the rights of creditors and secured parties in general, laws or principles of general application (including,
but not limited to, the abuse of rights (abus de droit), and the principle of good faith (principe de la bonne foi)), as well as public
policy, as defined in articles 17 through 19 of the Swiss Private International Law Act of 18 December 1987, as amended (the "**PILA** ")
as well as to the laws and rules of civil procedure and, as the case may be, arbitration rules applying to creditors or debtors and claimants
and defendants generally.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) In this Legal Opinion, we express no opinion (i) on the actual ability of the Company
to comply with the positive and negative undertakings set out in the Documents, nor (ii) on the accuracy or completeness of calculation,
valuation, statement of facts or representations and warranties set out in the Documents or the factual background assumed therein or
on the question whether any conditions therein stated have been fulfilled.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) We express no opinion on the content of the Registration Statement and as to whether
the Registration Statement is true and accurate or complete or not misleading. In particular, it should be noted that we have not been
responsible for investigating or verifying (i) the accuracy of the facts, including, but not limited to, business, financial and economic
information contained in the Registration Statement or (ii) that such facts are not misleading or (iii) that no material fact has been
omitted therefrom. Furthermore, we do not express any opinion with respect to financial statements or other financial or statistical information
contained in the Registration Statement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) The exercise of voting rights and rights related thereto with respect to any S-8 Shares
is only permissible after registration in the Company's share register as a shareholder with voting rights in accordance with the provisions
of, and subject to the limitations provided in, the Articles of Association.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) The RC Excerpt is not capable of revealing conclusively whether or not liquidation,
debt enforcement, moratorium, reorganization, composition, bankruptcy or insolvency proceedings are pending or whether or not an order
has been made by a court for the winding-up, dissolution, moratorium, reorganization, composition or administration of the Company, and
whether or not a liquidator, receiver, trustee, administrator or similar officer has been appointed in relation to the Company or any
of its assets or revenues.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) Court proceedings may be stayed if the subject of the proceedings is concurrently before
another court, and damages awarded by courts may be awarded depending upon the degree of fault of one party.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(viii) The recognition and enforcement in Switzerland of a foreign judgment rendered against
the Company is subject to the limitations set forth in (x) Convention on Jurisdiction and

![](image_004.jpg)

the Recognition and Enforcement of Judgments in Civil and Commercial Matters of 16 September 1988, as amended (the "**Lugano Convention**"), (y) such other international treaties under which Switzerland is bound and (z) the PILA. In particular, and without limitation to the foregoing, a judgment rendered by a foreign court may only be recognized and enforced in Switzerland if:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;i. (in case of (y) and (z) and, in certain exceptional cases, (x)) the foreign court
had jurisdiction;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ii. the judgment of such foreign court has become final and non-appealable, or, in the
case of (x), has become enforceable at an earlier stage;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;iii. the court procedures leading to the judgment followed the principles of due process
of law, including proper service of process; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;iv. the judgment of the foreign court on its merits does not violate Swiss law principles
of public policy; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;v. from a Swiss perspective, such foreign procedure does not formally or functionally qualify
as an insolvency, criminal or administrative procedure or as an insolvency-, criminal- or administrative-related procedure.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ix) It is doubtful whether a Swiss court would enforce a foreign judgment predicated upon
non-Swiss securities laws. In addition, enforceability of a judgment by a non-Swiss court in Switzerland may be limited if the defendant
can demonstrate that it was not effectively served with process.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(x) Pursuant to article 10 PILA and 31 Lugano Convention and article 13 of the Swiss Code
of Civil Procedure of 19 December 2008, Swiss courts may order preliminary measures even where they do not have jurisdiction over the
substance of the matter.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(xi) We have not reviewed any tax matters and do not express any opinion in relation to taxes.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(xii) The lawyers of our firm are admitted to the Zurich and/or Geneva bar and do not hold
themselves out to be experts in any laws other than the laws of Switzerland. Accordingly, our opinion is confined to the laws of Switzerland.
We have abstained from examining any issues of any other laws. This opinion relates to the laws of Switzerland in effect on the date hereof.
Such laws and the interpretation thereof are subject to change. In this Legal Opinion, Swiss legal concepts are expressed in English terms
and not in their original Swiss language. The concepts concerned may not be identical to the concepts described by the same English terms
as they exist under the laws of other jurisdictions. This Legal Opinion may, therefore, only be relied upon under the express condition
that any issues of interpretation or liability arising hereunder will be governed by Swiss law.

This Legal Opinion is exclusively governed by and construed in accordance with the substantive laws of Switzerland (without regard to any conflict of law rules that would cause the application of the laws of any other jurisdiction). This Legal Opinion is given solely on the condition that any dispute or legal action arising out of it or in relation to it against Niederer Kraft Frey Ltd, or any of

![](image_004.jpg)

its partners, directors, officers, executives or employees, shall be submitted to the exclusive jurisdiction of the courts of Zurich, Switzerland, subject to appeal to the Swiss Supreme Court (*Bundesgericht/Tribunal fédéral*) as provided by law.

This Legal Opinion is strictly limited to the matters stated in it and does not apply by implication to other matters. This Legal Opinion is given as of the date hereof. We disclaim any responsibility to notify of changes of law or facts affecting the opinions expressed herein that occur or come to our attention after the date hereof. By accepting receipt of this Legal Opinion, the recipient agrees to the stated limitations in scope, reliance and use of this Legal Opinion.

We hereby consent to the filing of this Legal Opinion as an exhibit to the Registration Statement. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the US Securities Act of 1933.

Yours Sincerely,

**Niederer Kraft Frey Ltd**

## Exhibit 23.1

**Exhibit 23.1**

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in this Registration Statement on Form S-8 of SOPHiA GENETICS SA of our report dated March 4, 2025 relating to the consolidated financial statements, which appears in SOPHiA GENETICS SA 's Annual Report on Form 20-F for the year ended December 31, 2024.

/s/ PricewaterhouseCoopers SA<br> Lausanne, Switzerland<br> July 11, 2025

## Ex-Filing

**Exhibit 107**

**FILING FEE TABLES FOR**

**FORM S-8**

**Calculation of Filing Fee Tables**

**Form S-8**

(Form Type)

**SOPHiA GENETICS SA**

(Exact Name of Registrant as Specified in its Charter)

<u>Newly Registered Securities</u>

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| | | | | | |
|:---|:---|:---|:---|:---|:---|
| **Title of Securities to be Registered** | **Amount to be Registered** **<sup>(1)</sup>** | **Proposed Maximum Offering Price Per Share** **<sup>(2)</sup>** | **Proposed Maximum Aggregate Offering Price** | **Fee Rate** | **Amount of Registration Fee** **<sup>(3)</sup>** |
| Ordinary shares, par value CHF 0.05 per share, to be issued pursuant to the SOPHiA GENETICS SA 2021 Equity Incentive Plan | 15693055 | $3.04 | $47706887.2 | 0.00015310 | $7303.93 |

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(1) This Registration Statement on Form S-8 (this "**Registration Statement**") covers ordinary shares, par value CHF 0.05 per share ()"**Shares** "), of SOPHiA GENETICS SA (the "**Registrant**") issuable pursuant to the SOPHiA GENETICS SA 2021 Equity Incentive Plan (the "**2021 Equity Incentive Plan** "). Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "**Securities Act** "), this Registration Statement shall also cover any additional Shares that become issuable under the 2021 Equity Incentive Plan by reason of any share dividend, share split or other similar transaction.

(2) Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(c) and Rule 457(h) under the Securities Act. The Proposed Maximum Offering Price Per Share is based on the average of the high and low prices of the Registrant's Shares as reported on the Nasdaq Global Market on July 7, 2025.

(3) Rounded up to the nearest penny.