# EDGAR Filing Document

**Accession Number:** 0001920938
**File Stem:** 0001140361-23-006947
**Filing Date:** 2023-2
**Character Count:** 24070
**Document Hash:** fb169172068dd0e76b1a650094376c28
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001140361-23-006947.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001140361-23-006947

**CONFORMED SUBMISSION TYPE**: SC 13G

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**GROUP MEMBERS**: ALEXANDER KARNAL

**GROUP MEMBERS**: BRAIDWELL MANAGEMENT LLC

**GROUP MEMBERS**: BRIAN KREITER

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Crinetics Pharmaceuticals, Inc.
- **CENTRAL INDEX KEY:** 0001658247
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 263744114
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-90577
- **FILM NUMBER:** 23629036

**BUSINESS ADDRESS:**
- **STREET 1:** 10222 BARNES CANYON ROAD, BLDG. #2
- **CITY:** SAN DIEGO
- **STATE:** CA
- **ZIP:** 92121
- **BUSINESS PHONE:** 858-450-6464

**MAIL ADDRESS:**
- **STREET 1:** 10222 BARNES CANYON ROAD, BLDG. #2
- **CITY:** SAN DIEGO
- **STATE:** CA
- **ZIP:** 92121
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** BRAIDWELL LP
- **CENTRAL INDEX KEY:** 0001920938
- **IRS NUMBER:** 861247398
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G

**BUSINESS ADDRESS:**
- **STREET 1:** ONE HARBOR POINT, 2200 ATLANTIC STREET
- **STREET 2:** 4TH FLOOR
- **CITY:** STAMFORD
- **STATE:** CT
- **ZIP:** 06902
- **BUSINESS PHONE:** 866-453-3929

**MAIL ADDRESS:**
- **STREET 1:** ONE HARBOR POINT, 2200 ATLANTIC STREET
- **STREET 2:** 4TH FLOOR
- **CITY:** STAMFORD
- **STATE:** CT
- **ZIP:** 06902

#### UNITED STATES

#### SECURITIES AND EXCHANGE COMMISSION

#### Washington, D.C. 20549

&nbsp;&nbsp;&nbsp;&nbsp; <br>

#### SCHEDULE 13G

#### Under the Securities Exchange Act of 1934

#### (Amendment No.)\*

#### CRINETICS PHARMACEUTICALS INC
(Name of Issuer)

#### Common Stock, par value $0.001 per share
(Title of Class of Securities)

#### 22663K107
(CUSIP Number)

#### December 31, 2022
(Date of Event which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

☑&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Rule 13d-1(b)

☐&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Rule 13d-1(c)

☐&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Rule 13d-1(d)

\* The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

Continued on following pages

Page 1 of 10 Pages

Exhibit Index: Page 9

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CUSIP No. 22663K107 Page 2 of 10 Pages

---

| | | | | |
|:---|:---|:---|:---|:---|
| 1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Names of Reporting Persons.<br> BRAIDWELL LP | Names of Reporting Persons.<br> BRAIDWELL LP | Names of Reporting Persons.<br> BRAIDWELL LP | Names of Reporting Persons.<br> BRAIDWELL LP |
| 2.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Check the Appropriate Box if a Member of a Group<br> (a) ☐<br> (b) ☐ | Check the Appropriate Box if a Member of a Group<br> (a) ☐<br> (b) ☐ | Check the Appropriate Box if a Member of a Group<br> (a) ☐<br> (b) ☐ | Check the Appropriate Box if a Member of a Group<br> (a) ☐<br> (b) ☐ |
| 3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| SEC Use Only | SEC Use Only | SEC Use Only | SEC Use Only |
| 4.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Citizenship or Place of Organization<br> Delaware | Citizenship or Place of Organization<br> Delaware | Citizenship or Place of Organization<br> Delaware | Citizenship or Place of Organization<br> Delaware |
| Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | 5.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;  | Sole Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| -0- |
| Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | 6.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;  | Shared Voting Power <br>| 3469674 |
| Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | 7.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;  | Sole Dispositive Power <br>| -0- |
| Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | 8.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;  | Shared Dispositive Power <br>| 3469674 |
| 9.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Aggregate Amount Beneficially Owned by Each Reporting Person<br> 3,469,674 | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 3,469,674 | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 3,469,674 | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 3,469,674 |
| 10.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)<br> ☐ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)<br> ☐ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)<br> ☐ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)<br> ☐ |
| 11.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Percent of Class Represented by Amount in Row (9)<br> 6.45%<sup>1</sup> | Percent of Class Represented by Amount in Row (9)<br> 6.45%<sup>1</sup> | Percent of Class Represented by Amount in Row (9)<br> 6.45%<sup>1</sup> | Percent of Class Represented by Amount in Row (9)<br> 6.45%<sup>1</sup> |
| 12.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Type of Reporting Person:<br> IA, PN | Type of Reporting Person:<br> IA, PN | Type of Reporting Person:<br> IA, PN | Type of Reporting Person:<br> IA, PN |

---

------

<sup>1</sup> Based on 53,810,476 Shares (as defined herein) outstanding as of November 9, 2022, as reported in the Issuer's quarterly report on Form 10-Q for the quarterly period ended September 30, 2022 filed with the Securities and Exchange Commission (the "SEC") on November 14, 2022.

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CUSIP No. 22663K107 Page 3 of 10 Pages

---

| | | | | |
|:---|:---|:---|:---|:---|
| 1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Names of Reporting Persons.<br> BRAIDWELL MANAGEMENT LLC | Names of Reporting Persons.<br> BRAIDWELL MANAGEMENT LLC | Names of Reporting Persons.<br> BRAIDWELL MANAGEMENT LLC | Names of Reporting Persons.<br> BRAIDWELL MANAGEMENT LLC |
| 2.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Check the Appropriate Box if a Member of a Group<br> (a) ☐<br> (b) ☐ | Check the Appropriate Box if a Member of a Group<br> (a) ☐<br> (b) ☐ | Check the Appropriate Box if a Member of a Group<br> (a) ☐<br> (b) ☐ | Check the Appropriate Box if a Member of a Group<br> (a) ☐<br> (b) ☐ |
| 3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| SEC Use Only | SEC Use Only | SEC Use Only | SEC Use Only |
| 4.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Citizenship or Place of Organization<br> Delaware | Citizenship or Place of Organization<br> Delaware | Citizenship or Place of Organization<br> Delaware | Citizenship or Place of Organization<br> Delaware |
| Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | 5.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;  | Sole Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| -0- |
| Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | 6.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;  | Shared Voting Power <br>| 3469674 |
| Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | 7.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;  | Sole Dispositive Power <br>| -0- |
| Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | 8.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;  | Shared Dispositive Power <br>| 3469674 |
| 9.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Aggregate Amount Beneficially Owned by Each Reporting Person<br> 3,469,674 | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 3,469,674 | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 3,469,674 | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 3,469,674 |
| 10.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)<br> ☐ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)<br> ☐ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)<br> ☐ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)<br> ☐ |
| 11.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Percent of Class Represented by Amount in Row (9)<br> 6.45%<sup>1</sup> | Percent of Class Represented by Amount in Row (9)<br> 6.45%<sup>1</sup> | Percent of Class Represented by Amount in Row (9)<br> 6.45%<sup>1</sup> | Percent of Class Represented by Amount in Row (9)<br> 6.45%<sup>1</sup> |
| 12.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Type of Reporting Person:<br> HC, OO | Type of Reporting Person:<br> HC, OO | Type of Reporting Person:<br> HC, OO | Type of Reporting Person:<br> HC, OO |

---

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CUSIP No. 22663K107 Page 4 of 10 Pages

---

| | | | | |
|:---|:---|:---|:---|:---|
| 1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Names of Reporting Persons.<br> ALEXANDER T. KARNAL | Names of Reporting Persons.<br> ALEXANDER T. KARNAL | Names of Reporting Persons.<br> ALEXANDER T. KARNAL | Names of Reporting Persons.<br> ALEXANDER T. KARNAL |
| 2.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Check the Appropriate Box if a Member of a Group<br> (a) ☐<br> (b) ☐ | Check the Appropriate Box if a Member of a Group<br> (a) ☐<br> (b) ☐ | Check the Appropriate Box if a Member of a Group<br> (a) ☐<br> (b) ☐ | Check the Appropriate Box if a Member of a Group<br> (a) ☐<br> (b) ☐ |
| 3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| SEC Use Only | SEC Use Only | SEC Use Only | SEC Use Only |
| 4.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Citizenship or Place of Organization<br> United States of America | Citizenship or Place of Organization<br> United States of America | Citizenship or Place of Organization<br> United States of America | Citizenship or Place of Organization<br> United States of America |
| Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | 5.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;  | Sole Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| -0- |
| Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | 6.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;  | Shared Voting Power <br>| 3469674 |
| Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | 7.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;  | Sole Dispositive Power <br>| -0- |
| Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | 8.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;  | Shared Dispositive Power <br>| 3469674 |
| 9.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Aggregate Amount Beneficially Owned by Each Reporting Person<br> 3,469,674 | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 3,469,674 | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 3,469,674 | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 3,469,674 |
| 10.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)<br> ☐ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)<br> ☐ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)<br> ☐ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)<br> ☐ |
| 11.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Percent of Class Represented by Amount in Row (9)<br> 6.45%<sup>1</sup> | Percent of Class Represented by Amount in Row (9)<br> 6.45%<sup>1</sup> | Percent of Class Represented by Amount in Row (9)<br> 6.45%<sup>1</sup> | Percent of Class Represented by Amount in Row (9)<br> 6.45%<sup>1</sup> |
| 12.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Type of Reporting Person:<br> IN, HC | Type of Reporting Person:<br> IN, HC | Type of Reporting Person:<br> IN, HC | Type of Reporting Person:<br> IN, HC |

---

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CUSIP No. 22663K107 Page 5 of 10 Pages

---

| | | | | |
|:---|:---|:---|:---|:---|
| 1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Names of Reporting Persons.<br> BRIAN J. KREITER | Names of Reporting Persons.<br> BRIAN J. KREITER | Names of Reporting Persons.<br> BRIAN J. KREITER | Names of Reporting Persons.<br> BRIAN J. KREITER |
| <br> 2.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Check the Appropriate Box if a Member of a Group<br> (a) ☐<br> (b) ☐ | Check the Appropriate Box if a Member of a Group<br> (a) ☐<br> (b) ☐ | Check the Appropriate Box if a Member of a Group<br> (a) ☐<br> (b) ☐ | Check the Appropriate Box if a Member of a Group<br> (a) ☐<br> (b) ☐ |
| 3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| SEC Use Only | SEC Use Only | SEC Use Only | SEC Use Only |
| 4.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Citizenship or Place of Organization<br> United States of America | Citizenship or Place of Organization<br> United States of America | Citizenship or Place of Organization<br> United States of America | Citizenship or Place of Organization<br> United States of America |
| Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | 5.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;  | Sole Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| -0- |
| Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | 6.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;  | Shared Voting Power <br>| 3469674 |
| Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | 7.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;  | Sole Dispositive Power <br>| -0- |
| Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by Each<br> Reporting<br> Person With | 8.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;  | Shared Dispositive Power <br>| 3469674 |
| 9.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Aggregate Amount Beneficially Owned by Each Reporting Person<br> 3,469,674 | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 3,469,674 | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 3,469,674 | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 3,469,674 |
| 10.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)<br> ☐ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)<br> ☐ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)<br> ☐ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)<br> ☐ |
| 11.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Percent of Class Represented by Amount in Row (9)<br> 6.45%<sup>1</sup> | Percent of Class Represented by Amount in Row (9)<br> 6.45%<sup>1</sup> | Percent of Class Represented by Amount in Row (9)<br> 6.45%<sup>1</sup> | Percent of Class Represented by Amount in Row (9)<br> 6.45%<sup>1</sup> |
| 12.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <br>| Type of Reporting Person:<br> HC, OO | Type of Reporting Person:<br> HC, OO | Type of Reporting Person:<br> HC, OO | Type of Reporting Person:<br> HC, OO |

---

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CUSIP No. 22663K107 Page 6 of 10 Pages

**Item 1(a).**

**Name of Issuer:**

**** 

<br> Crinetics Pharmaceuticals, Inc.

**Item 1(b).**

**Address of Issuer's Principal Executive Offices:**

**** 

<br> 10222 Barnes Canyon, Bldg. #2

San Diego, CA 92121

**Item 2(a).**

**Name of Person Filing**

This initial filing is being jointly filed by Braidwell LP, Braidwell Management LLC, Alexander Karnal and Brian Kreiter (the "Reporting Persons").

**Item 2(b).**

**Address of Principal Business Office or, if None, Residence:**

The business address of each Reporting Person is:

2200 Atlantic St

4<sup>th</sup> Floor

Stamford, CT 06902

**Item 2(c).**

**Citizenship:**

Braidwell LP is a limited partnership organized under the laws of the State of Delaware.

Braidwell Management LLC is a limited liability company organized under the laws of the State of Delaware. Alexander Karnal and Brian Kreiter are both citizens of the United States of America.

**Item 2(d).**

**Title of Class of Securities:**

Common Stock, par value $0.001 per share (the "Shares")

**Item 2(e).**

**CUSIP Number:**

**** 

22663K107

**Item 3.**

**If This Statement is Filed Pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), Check Whether the Person Filing is a:**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E)

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G)

**Item 4.**

**Ownership:**

**** 

<br> **Item 4(a)**

**Amount Beneficially Owned:**

Items 5-9 of each cover page are incorporated by reference. Each Reporting Person may be deemed to be the beneficial owner of 3,469,674 Shares, which are directly owned by Braidwell Partners Master Fund LP.

------

CUSIP No. 22663K107 Page 7 of 10 Pages

**Item 4(b)**

**Percent of Class:**

Each Reporting Person may be deemed to beneficially own 6.45% of the Shares, which is calculated based on 53,810,476 Shares outstanding as of November 9, 2022, as reported in the Issuer's quarterly report on Form 10-Q for the quarterly period ended September 30, 2022 filed with the SEC on November 14, 2022.

**Item 4(c)**

**Number of Shares as to which such person has:**

(i) Sole power to vote or direct the vote: -0-

(ii) Shared power to vote or direct the vote: 3,469,674

(iii) Sole power to dispose or direct the disposition of: -0-

(iv) Shared power to dispose or direct the disposition of: 3,469,674

**Item 5.**

**Ownership of Five Percent or Less of a Class:**

**** 

<br> n/a

**Item 6.**

**Ownership of More than Five Percent on Behalf of Another Person:**

**** 

<br> n/a

 **Item 7.**

#### Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person:

The information in Item 4 is incorporated herein.

**Item 8.**

**Identification and Classification of Members of the Group:**

**** 

<br> n/a

**Item 9.**

**Notice of Dissolution of Group:**

**** 

<br> n/a

**Item 10.**

**Certification:**

**** 

<br> By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under §240.14a-11.

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CUSIP No. 22663K107 Page 8 of 10 Pages

#### SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

---

| | | |
|:---|:---|:---|
| February 14, 2023 |  |  |
|  | **BRAIDWELL LP** | **BRAIDWELL LP** |
|  | BY: | BRAIDWELL MANAGEMENT, LLC,<br> ITS GENERAL PARTNER |
|  | BY: | /S/ MANISH K. MITAL |
|  |  | NAME: MANISH K. MITAL |
|  |  | TITLE: AUTHORIZED SIGNATORY |
|  | **BRAIDWELL MANAGEMENT LLC** | **BRAIDWELL MANAGEMENT LLC** |
|  | BY: | /S/ MANISH K. MITAL |
|  |  | NAME: MANISH K. MITAL |
|  |  | TITLE: AUTHORIZED SIGNATORY |
|  | **ALEXANDER T. KARNAL** | **ALEXANDER T. KARNAL** |
|  | /s/ ALEXANDER T. KARNAL | /s/ ALEXANDER T. KARNAL |
|  | **BRIAN J. KREITER** | **BRIAN J. KREITER** |
|  | /s/ BRIAN J. KREITER | /s/ BRIAN J. KREITER |

---

&nbsp;&nbsp;&nbsp;&nbsp;<br>

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CUSIP No. 22663K107 Page 9 of 10 Pages

#### EXHIBIT INDEX
<u> Ex. </u> <u> Page No. </u> <br> A Joint Filing Agreement, dated February 14, 2023, by and among the Reporting Persons 10

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CUSIP No. 22663K107 Page 10 of 10 Pages

#### EXHIBIT A

#### JOINT FILING AGREEMENT
The undersigned hereby agree that the statement on Schedule 13G with respect to the Common Stock of Crinetics Pharmaceuticals, Inc. dated as of February 14, 2023 is, and any amendments thereto (including amendments on Schedule 13D) signed by each of the undersigned shall be, filed on behalf of each of us pursuant to and in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended.

---

| | | |
|:---|:---|:---|
| February 14, 2023 |  |  |
|  | **BRAIDWELL LP** | **BRAIDWELL LP** |
|  | BY: | BRAIDWELL MANAGEMENT, LLC,<br> ITS GENERAL PARTNER |
|  | BY: | /S/ MANISH K. MITAL |
|  |  | NAME: MANISH K. MITAL |
|  |  | TITLE: AUTHORIZED SIGNATORY |
|  | **BRAIDWELL MANAGEMENT LLC** | **BRAIDWELL MANAGEMENT LLC** |
|  | BY: | /S/ MANISH K. MITAL |
|  |  | NAME: MANISH K. MITAL |
|  |  | TITLE: AUTHORIZED SIGNATORY |
|  | **ALEXANDER T. KARNAL** | **ALEXANDER T. KARNAL** |
|  | /s/ ALEXANDER T. KARNAL | /s/ ALEXANDER T. KARNAL |
|  | **BRIAN J. KREITER** | **BRIAN J. KREITER** |
|  | /s/ BRIAN J. KREITER | /s/ BRIAN J. KREITER |

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