# EDGAR Filing Document

**Accession Number:** 0001682639
**File Stem:** 0001104659-25-119131
**Filing Date:** 2025-12
**Character Count:** 2135
**Document Hash:** f92bb97d6d942f1ef09bfc9c80087223
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-25-119131.hdr.sgml**: 20260320

**ACCESSION NUMBER**: 0001104659-25-119131

**CONFORMED SUBMISSION TYPE**: CORRESP

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20251208

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** HYPERION DEFI, INC.
- **CENTRAL INDEX KEY:** 0001682639
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 471178401
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** CORRESP

**BUSINESS ADDRESS:**
- **STREET 1:** 295 MADISON AVENUE
- **STREET 2:** SUITE 2400
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10017
- **BUSINESS PHONE:** 833-393-6684

**MAIL ADDRESS:**
- **STREET 1:** 295 MADISON AVENUE
- **STREET 2:** SUITE 2400
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10017

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** EYENOVIA, INC.
- **DATE OF NAME CHANGE:** 20160818

December 8, 2025

**Via EDGAR**

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attn: Jimmy MacNamara

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| | |
|:---|:---|
| **Re:** | **Hyperion DeFi, Inc. (the "Company")** |
|  | **Registration Statement Filed on Form S-3 (the "Registration Statement")** |
|  | **File No. 333-291570** |

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Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, the Company hereby respectfully requests that the effective date for the above-referenced Registration Statement be accelerated to 8:00 a.m., Eastern Time, on December 9, 2025, or as soon as practicable thereafter.

Please contact Megan Gates of Covington & Burling LLP at (617) 785-4653 or mgates@cov.com with any questions you may have regarding this request. In addition, please notify Ms. Gates by telephone when this request for acceleration has been granted.

---

| | |
|:---|:---|
|  | Respectfully, |
|  | **Hyperion DeFi, Inc.** |
| By: | /s/ Hyunsu Jung |
| Name: | Hyunsu Jung |
| Title: | Interim Chief Executive Officer |

---

cc: Megan Gates, Covington & Burling LLP