# EDGAR Filing Document

**Accession Number:** 0000052848
**File Stem:** 0001752724-23-016404
**Filing Date:** 2023-1
**Character Count:** 177621
**Document Hash:** f0e27f02bb2dcf0819848e8e359959e1
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001752724-23-016404.hdr.sgml**: 20230127

**ACCESSION NUMBER**: 0001752724-23-016404

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20221130

**FILED AS OF DATE**: 20230127

**DATE AS OF CHANGE**: 20230127

**PERIOD START**: 20230831

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** VANGUARD WORLD FUND
- **CENTRAL INDEX KEY:** 0000052848
- **IRS NUMBER:** 046035483
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 0831

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-01027
- **FILM NUMBER:** 23561740

**BUSINESS ADDRESS:**
- **STREET 1:** PO BOX 2600
- **STREET 2:** V26
- **CITY:** VALLEY FORGE
- **STATE:** PA
- **ZIP:** 19482
- **BUSINESS PHONE:** 6106691000

**MAIL ADDRESS:**
- **STREET 1:** PO BOX 2600
- **STREET 2:** V26
- **CITY:** VALLEY FORGE
- **STATE:** PA
- **ZIP:** 19482

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** VANGUARD WORLD FUNDS
- **DATE OF NAME CHANGE:** 20020402

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** VANGUARD WORLD FUND INC
- **DATE OF NAME CHANGE:** 19920703

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** IVEST FUND INC
- **DATE OF NAME CHANGE:** 19850923

## Series and Classes Contracts Data

### Vanguard Health Care Index Fund (Series ID: S000004450)

| Class ID   | Class Name     | Ticker Symbol   |
|:---|:---|:---|
| C000012222 | Admiral Shares | VHCIX           |
| C000012223 | ETF Shares     | VHT             |

## Nport-Ex

Vanguard<sup>®</sup> Health Care Index Fund

#### Schedule of Investments (unaudited)
As of November 30, 2022

The fund files its complete schedule of portfolio holdings with the Securities and Exchange Commission (SEC) for the first and third quarters of each fiscal year as an exhibit to its reports on Form N-PORT. The fund's Form N-PORT reports are available on the SEC's website at www.sec.gov.

---

| | | | |
|:---|:---|:---|:---|
|  |  | Shares | Market<br> Value<br> ($000) |
| **Common Stocks (99.9%)** | **Common Stocks (99.9%)** | **Common Stocks (99.9%)** | **Common Stocks (99.9%)** |
| **Biotechnology (18.7%)** | **Biotechnology (18.7%)** | **Biotechnology (18.7%)** | **Biotechnology (18.7%)** |
|  | AbbVie Inc. | 6112253 | 985173 |
|  | Amgen Inc. | 1849247 | 529624 |
|  | Gilead Sciences Inc. | 4132776 | 362982 |
| <sup>\*</sup> | Vertex Pharmaceuticals Inc. | 886568 | 280510 |
| <sup>\*</sup> | Regeneron Pharmaceuticals Inc. | 370551 | 278543 |
| <sup>\*</sup> | Moderna Inc. | 1149546 | 202217 |
| <sup>\*</sup> | Biogen Inc. | 501667 | 153094 |
| <sup>\*</sup> | Alnylam Pharmaceuticals Inc. | 389939 | 86017 |
| <sup>\*</sup> | Horizon Therapeutics plc | 756621 | 75882 |
| <sup>\*</sup> | BioMarin Pharmaceutical Inc. | 641109 | 64739 |
| <sup>\*</sup> | Seagen Inc. | 478297 | 58060 |
| <sup>\*</sup> | Incyte Corp. | 653408 | 52057 |
| <sup>\*</sup> | United Therapeutics Corp. | 157333 | 44036 |
| <sup>\*</sup> | Neurocrine Biosciences Inc. | 330560 | 42001 |
| <sup>\*</sup> | Sarepta Therapeutics Inc. | 272459 | 33461 |
| <sup>\*</sup> | Exact Sciences Corp. | 611908 | 27505 |
| <sup>\*</sup> | Halozyme Therapeutics Inc. | 476388 | 27278 |
| <sup>\*</sup> | Karuna Therapeutics Inc. | 92563 | 21781 |
| <sup>\*</sup> | Exelixis Inc. | 1112656 | 19004 |
| <sup>\*</sup> | Ionis Pharmaceuticals Inc. | 441150 | 17995 |
| <sup>\*</sup> | Apellis Pharmaceuticals Inc. | 303830 | 15170 |
| <sup>\*</sup> | Natera Inc. | 356083 | 14642 |
| <sup>\*</sup> | Alkermes plc | 567474 | 14062 |
| <sup>\*</sup> | CRISPR Therapeutics AG | 256266 | 14041 |
| <sup>\*</sup> | Cytokinetics Inc. | 309293 | 13145 |
| <sup>\*</sup> | Mirati Therapeutics Inc. | 134777 | 12316 |
| <sup>\*</sup> | Intellia Therapeutics Inc. | 236132 | 12151 |
| <sup>\*</sup> | Arrowhead Pharmaceuticals Inc. | 347882 | 11202 |
| <sup>\*</sup> | Blueprint Medicines Corp. | 206763 | 9881 |
| <sup>\*</sup> | Denali Therapeutics Inc. | 297877 | 9505 |
| <sup>\*</sup> | PTC Therapeutics Inc. | 222108 | 9215 |
| <sup>\*</sup> | Beam Therapeutics Inc. | 194776 | 8997 |
| <sup>\*</sup> | Amicus Therapeutics Inc. | 726618 | 8792 |
| <sup>\*</sup> | BioCryst Pharmaceuticals Inc. | 642066 | 8578 |
| <sup>\*</sup> | Insmed Inc. | 463398 | 8568 |
| <sup>\*</sup> | Ultragenyx Pharmaceutical Inc. | 229836 | 8343 |
| <sup>\*</sup> | Vaxcyte Inc. | 179798 | 8281 |
| <sup>\*</sup> | Sage Therapeutics Inc. | 185066 | 7595 |
| <sup>\*</sup> | Vir Biotechnology Inc. | 252731 | 7132 |
| <sup>\*</sup> | Prothena Corp. plc | 113370 | 7087 |
| <sup>\*</sup> | Veracyte Inc. | 246705 | 6844 |
| <sup>\*</sup> | IVERIC bio Inc. | 285893 | 6753 |

---

------

---

| | | | |
|:---|:---|:---|:---|
|  |  | Shares | Market<br> Value<br> ($000) |
| <sup>\*</sup> | ACADIA Pharmaceuticals Inc. | 421098 | 6561 |
| <sup>\*</sup> | Cerevel Therapeutics Holdings Inc. | 215488 | 6241 |
| <sup>\*</sup> | Xenon Pharmaceuticals Inc. | 161454 | 5954 |
| <sup>\*</sup> | Xencor Inc. | 196346 | 5835 |
| <sup>\*</sup> | Ironwood Pharmaceuticals Inc. Class A | 476645 | 5772 |
|  | Catalyst Pharmaceuticals Inc. | 337831 | 5665 |
| <sup>\*</sup> | Myriad Genetics Inc. | 279283 | 5658 |
| <sup>\*</sup> | Fate Therapeutics Inc. | 268674 | 5594 |
| <sup>\*</sup> | Arcus Biosciences Inc. | 149885 | 5271 |
| <sup>\*</sup> | Dynavax Technologies Corp. | 416506 | 5169 |
| <sup>\*</sup> | Agios Pharmaceuticals Inc. | 170104 | 5127 |
| <sup>\*</sup> | Twist Bioscience Corp. | 184287 | 5040 |
| <sup>\*</sup> | REVOLUTION Medicines Inc. | 212347 | 5009 |
| <sup>\*</sup> | Relay Therapeutics Inc. | 269387 | 5005 |
| <sup>\*</sup> | Krystal Biotech Inc. | 62438 | 4854 |
| <sup>\*</sup> | Celldex Therapeutics Inc. | 129920 | 4819 |
| <sup>\*</sup> | Akero Therapeutics Inc. | 101739 | 4731 |
| <sup>\*,1</sup> | Novavax Inc. | 271256 | 4473 |
| <sup>\*</sup> | FibroGen Inc. | 308638 | 4435 |
| <sup>\*</sup> | TG Therapeutics Inc. | 478674 | 4222 |
| <sup>\*</sup> | Myovant Sciences Ltd. | 149662 | 4020 |
| <sup>\*</sup> | Syndax Pharmaceuticals Inc. | 166658 | 3993 |
| <sup>\*</sup> | MannKind Corp. | 845638 | 3958 |
| <sup>\*</sup> | UniQure NV | 144890 | 3834 |
| <sup>\*</sup> | Travere Thrapeutics Inc. | 188627 | 3797 |
| <sup>\*</sup> | Rhythm Pharmaceuticals Inc. | 140347 | 3757 |
| <sup>\*</sup> | ImmunoGen Inc. | 688724 | 3574 |
| <sup>\*</sup> | Rocket Pharmaceuticals Inc. | 187707 | 3544 |
| <sup>\*</sup> | Zentalis Pharmaceuticals Inc. | 158812 | 3513 |
| <sup>\*</sup> | Kymera Therapeutics Inc. | 116228 | 3368 |
| <sup>\*</sup> | Avid Bioservices Inc. | 214055 | 3352 |
| <sup>\*</sup> | Vericel Corp. | 146057 | 3334 |
|  | Chinook Therapeutics Inc. | 141361 | 3202 |
| <sup>\*</sup> | Kura Oncology Inc. | 195176 | 3078 |
| <sup>\*</sup> | REGENXBIO Inc. | 126188 | 3016 |
| <sup>\*</sup> | Enanta Pharmaceuticals Inc. | 67687 | 2964 |
| <sup>\*</sup> | Allogene Therapeutics Inc. | 296735 | 2926 |
| <sup>\*</sup> | Madrigal Pharmaceuticals Inc. | 40997 | 2874 |
| <sup>\*</sup> | Keros Therapeutics Inc. | 53501 | 2666 |
| <sup>\*</sup> | Verve Therapeutics Inc. | 114143 | 2652 |
| <sup>\*</sup> | Iovance Biotherapeutics Inc. | 409172 | 2619 |
| <sup>\*</sup> | Viridian Therapeutics Inc. | 103458 | 2614 |
| <sup>\*</sup> | Arcutis Biotherapeutics Inc. | 145672 | 2510 |
| <sup>\*</sup> | Editas Medicine Inc. Class A | 236635 | 2508 |
| <sup>\*</sup> | Inhibrx Inc. | 80900 | 2425 |
| <sup>\*,1</sup> | Anavex Life Sciences Corp. | 272485 | 2403 |
| <sup>\*</sup> | CareDx Inc. | 184176 | 2385 |
| <sup>\*</sup> | Agenus Inc. | 881957 | 2381 |
| <sup>\*</sup> | Crinetics Pharmaceuticals Inc. | 130533 | 2333 |
| <sup>\*,1</sup> | ImmunityBio Inc. | 419160 | 2310 |
| <sup>\*</sup> | SpringWorks Therapeutics Inc. | 94573 | 2287 |
| <sup>\*</sup> | Seres Therapeutics Inc. | 344690 | 2240 |
| <sup>\*</sup> | Deciphera Pharmaceuticals Inc. | 140016 | 2228 |
| <sup>\*</sup> | Bridgebio Pharma Inc. | 233872 | 2191 |
| <sup>\*</sup> | Aurinia Pharmaceuticals Inc. | 414285 | 2125 |
| <sup>\*</sup> | Vanda Pharmaceuticals Inc. | 192006 | 2095 |
| <sup>\*</sup> | Sorrento Therapeutics Inc. | 1557620 | 2025 |
| <sup>\*</sup> | Morphic Holding Inc. | 72573 | 1997 |

---

------

---

| | | | |
|:---|:---|:---|:---|
|  |  | Shares | Market<br> Value<br> ($000) |
| <sup>\*</sup> | 2seventy bio Inc. | 125081 | 1960 |
| <sup>\*</sup> | Nuvalent Inc. Class A | 59510 | 1957 |
| <sup>\*</sup> | ADMA Biologics Inc. | 577518 | 1929 |
| <sup>\*</sup> | EQRx Inc. | 511138 | 1922 |
| <sup>\*</sup> | Emergent BioSolutions Inc. | 155467 | 1912 |
| <sup>\*</sup> | Kiniksa Pharmaceuticals Ltd. Class A | 108684 | 1829 |
| <sup>\*</sup> | Inovio Pharmaceuticals Inc. | 864031 | 1763 |
| <sup>\*</sup> | Rapt Therapeutics Inc. | 99104 | 1752 |
| <sup>\*</sup> | Immunovant Inc. | 133534 | 1751 |
| <sup>\*</sup> | Replimune Group Inc. | 85352 | 1747 |
| <sup>\*</sup> | Intercept Pharmaceuticals Inc. | 115065 | 1716 |
|  | Altimmune Inc. | 169558 | 1687 |
| <sup>\*</sup> | Sangamo Therapeutics Inc. | 453357 | 1659 |
| <sup>\*</sup> | Imago Biosciences Inc. | 46128 | 1646 |
| <sup>\*</sup> | AnaptysBio Inc. | 58985 | 1630 |
| <sup>\*</sup> | Alector Inc. | 187731 | 1594 |
| <sup>\*</sup> | Recursion Pharmaceuticals Inc. Class A | 169462 | 1593 |
| <sup>\*</sup> | Merus NV | 103067 | 1582 |
| <sup>\*</sup> | Avidity Biosciences Inc. | 135197 | 1574 |
| <sup>\*</sup> | Arcturus Therapeutics Holdings Inc. | 84334 | 1555 |
| <sup>\*</sup> | Gossamer Bio Inc. | 178825 | 1531 |
| <sup>\*</sup> | Nurix Therapeutics Inc. | 122127 | 1513 |
| <sup>\*,1</sup> | Sana Biotechnology Inc. | 298698 | 1491 |
| <sup>\*</sup> | Eagle Pharmaceuticals Inc. | 41003 | 1489 |
|  | Point Biopharma Global Inc. | 215896 | 1470 |
| <sup>\*</sup> | Prometheus Biosciences Inc. | 35408 | 1456 |
| <sup>\*</sup> | Coherus Biosciences Inc. | 211926 | 1454 |
| <sup>\*</sup> | Cogent Biosciences Inc. | 113653 | 1430 |
| <sup>\*</sup> | iTeos Therapeutics Inc. | 66515 | 1340 |
| <sup>\*</sup> | Atara Biotherapeutics Inc. | 282942 | 1282 |
| <sup>\*</sup> | Tango Therapeutics Inc. | 167737 | 1260 |
| <sup>\*,1</sup> | Ocugen Inc. | 737828 | 1151 |
| <sup>\*</sup> | Adicet Bio Inc. | 61581 | 1120 |
| <sup>\*</sup> | MacroGenics Inc. | 170053 | 1093 |
| <sup>\*</sup> | Arcellx Inc. | 53004 | 1057 |
| <sup>\*</sup> | Repare Therapeutics Inc. | 64323 | 1031 |
| <sup>\*</sup> | Protagonist Therapeutics Inc. | 127749 | 1010 |
| <sup>\*</sup> | Heron Therapeutics Inc. | 355587 | 964 |
| <sup>\*,1</sup> | Vera Therapeutics Inc. Class A | 51914 | 867 |
| <sup>\*</sup> | HilleVax Inc. | 40530 | 811 |
| <sup>\*</sup> | MiMedx Group Inc. | 249075 | 809 |
| <sup>\*</sup> | Erasca Inc. | 103650 | 783 |
| <sup>\*</sup> | IGM Biosciences Inc. | 33816 | 744 |
| <sup>\*</sup> | PMV Pharmaceuticals Inc. | 69752 | 696 |
| <sup>\*</sup> | ALX Oncology Holdings Inc. | 62053 | 689 |
| <sup>\*</sup> | Cullinan Oncology Inc. | 48662 | 605 |
| <sup>\*</sup> | Humacyte Inc. | 193941 | 605 |
|  | Entrada Therapeutics Inc. | 38059 | 570 |
| <sup>\*</sup> | MeiraGTx Holdings plc | 91049 | 561 |
| <sup>\*</sup> | Organogenesis Holdings Inc. Class A | 198501 | 544 |
| <sup>\*</sup> | Monte Rosa Therapeutics Inc. | 63598 | 539 |
| <sup>\*</sup> | Vaxart Inc. | 429816 | 507 |
| <sup>\*</sup> | Y-mAbs Therapeutics Inc. | 112294 | 502 |
| <sup>\*</sup> | Foghorn Therapeutics Inc. | 71181 | 480 |
| <sup>\*,1</sup> | Century Therapeutics Inc. | 40551 | 426 |
| <sup>\*</sup> | Stoke Therapeutics Inc. | 54149 | 408 |
| <sup>\*</sup> | Rigel Pharmaceuticals Inc. | 585472 | 393 |
| <sup>\*</sup> | Aerovate Therapeutics Inc. | 20853 | 393 |

---

------

---

| | | | |
|:---|:---|:---|:---|
|  |  | Shares | Market<br> Value<br> ($000) |
| <sup>\*,2</sup> | PDL BioPharma Inc. | 311327 | 392 |
| <sup>\*</sup> | Janux Therapeutics Inc. | 28442 | 388 |
| <sup>\*,1,2</sup> | Contra Zogenix Inc. CVR | 93751 | 188 |
| <sup>\*</sup> | Geron Corp. Warrant Exp. 12/31/25 | 152449 | 78 |
| <sup>\*,2</sup> | Progenics Pharmaceuticals Inc. CVR | 215826 |  |
| <sup>\*</sup> | Advaxis Inc. Warrants Exp. 9/11/24 | 7710 |  |
| <sup>\*,2</sup> | Prevail Therapeutics Inc. CVR | 78 |  |
|  |  |  | **3869670** |
| **Health Care Equipment & Supplies (18.0%)** | **Health Care Equipment & Supplies (18.0%)** | **Health Care Equipment & Supplies (18.0%)** | **Health Care Equipment & Supplies (18.0%)** |
|  | Abbott Laboratories | 6053799 | 651268 |
|  | Medtronic plc | 4596540 | 363310 |
| <sup>\*</sup> | Intuitive Surgical Inc. | 1234567 | 333815 |
|  | Stryker Corp. | 1177092 | 275310 |
|  | Becton Dickinson and Co. | 985817 | 245804 |
| <sup>\*</sup> | Boston Scientific Corp. | 4948804 | 224032 |
| <sup>\*</sup> | Edwards Lifesciences Corp. | 2143075 | 165553 |
| <sup>\*</sup> | DexCom Inc. | 1357209 | 157816 |
| <sup>\*</sup> | IDEXX Laboratories Inc. | 287843 | 122584 |
|  | ResMed Inc. | 506211 | 116530 |
|  | Baxter International Inc. | 1740664 | 98400 |
|  | Zimmer Biomet Holdings Inc. | 725254 | 87103 |
| <sup>\*</sup> | Insulet Corp. | 240032 | 71858 |
| <sup>\*</sup> | Hologic Inc. | 863022 | 65728 |
|  | STERIS plc | 345703 | 64211 |
| <sup>\*</sup> | ABIOMED Inc. | 157171 | 59378 |
|  | Cooper Cos. Inc. | 170569 | 53959 |
| <sup>\*</sup> | Align Technology Inc. | 256570 | 50457 |
|  | Teleflex Inc. | 162152 | 37963 |
| <sup>\*</sup> | Shockwave Medical Inc. | 124217 | 31501 |
| <sup>\*</sup> | Penumbra Inc. | 124465 | 26077 |
| <sup>\*</sup> | Novocure Ltd. | 326045 | 25053 |
| <sup>\*</sup> | Masimo Corp. | 172535 | 25007 |
|  | DENTSPLY SIRONA Inc. | 744600 | 22532 |
| <sup>\*</sup> | Globus Medical Inc. Class A | 266344 | 19680 |
| <sup>\*</sup> | Envista Holdings Corp. | 564929 | 19275 |
| <sup>\*</sup> | QuidelOrtho Corp. | 173503 | 15201 |
| <sup>\*</sup> | Haemonetics Corp. | 177627 | 15153 |
| <sup>\*</sup> | Lantheus Holdings Inc. | 237396 | 14738 |
| <sup>\*</sup> | Integra LifeSciences Holdings Corp. | 259723 | 14269 |
| <sup>\*</sup> | Merit Medical Systems Inc. | 195870 | 14103 |
| <sup>\*</sup> | Neogen Corp. | 747797 | 12383 |
| <sup>\*</sup> | iRhythm Technologies Inc. | 103840 | 11324 |
| <sup>\*</sup> | ICU Medical Inc. | 70177 | 11174 |
| <sup>\*</sup> | Inari Medical Inc. | 147774 | 10873 |
| <sup>\*</sup> | LivaNova plc | 185483 | 10270 |
| <sup>\*</sup> | Tandem Diabetes Care Inc. | 222071 | 9338 |
| <sup>\*</sup> | Axonics Inc. | 135228 | 9260 |
| <sup>\*</sup> | Enovis Corp. | 168061 | 9097 |
|  | CONMED Corp. | 105369 | 8730 |
| <sup>\*</sup> | Integer Holdings Corp. | 114752 | 8528 |
| <sup>\*</sup> | STAAR Surgical Co. | 140993 | 8052 |
| <sup>\*</sup> | Omnicell Inc. | 153491 | 7922 |
| <sup>\*</sup> | Glaukos Corp. | 164697 | 7670 |
| <sup>\*</sup> | NuVasive Inc. | 179976 | 6990 |
| <sup>\*</sup> | AtriCure Inc. | 152785 | 6961 |
|  | Embecta Corp. | 200034 | 6585 |
| <sup>\*</sup> | Silk Road Medical Inc. | 121435 | 6466 |
| <sup>\*</sup> | TransMedics Group Inc. | 102959 | 6370 |

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| | | | |
|:---|:---|:---|:---|
|  |  | Shares | Market<br> Value<br> ($000) |
| <sup>\*</sup> | Nevro Corp. | 116460 | 5440 |
| <sup>\*</sup> | Meridian Bioscience Inc. | 150765 | 4824 |
| <sup>\*</sup> | Avanos Medical Inc. | 160678 | 4322 |
| <sup>\*</sup> | Establishment Labs Holdings Inc. | 66775 | 4258 |
|  | LeMaitre Vascular Inc. | 68393 | 3204 |
|  | Mesa Laboratories Inc. | 18325 | 3100 |
|  | Atrion Corp. | 4934 | 2984 |
| <sup>\*</sup> | Outset Medical Inc. | 140242 | 2956 |
| <sup>\*</sup> | Varex Imaging Corp. | 137139 | 2913 |
| <sup>\*</sup> | Alphatec Holdings Inc. | 253930 | 2605 |
| <sup>\*</sup> | Cutera Inc. | 54275 | 2582 |
| <sup>\*</sup> | Cerus Corp. | 610140 | 2441 |
| <sup>\*</sup> | Heska Corp. | 35411 | 2279 |
| <sup>\*</sup> | ViewRay Inc. | 471366 | 2272 |
| <sup>\*</sup> | OrthoPediatrics Corp. | 48732 | 2144 |
| <sup>\*</sup> | Cardiovascular Systems Inc. | 139622 | 1956 |
| <sup>\*</sup> | Figs Inc. Class A | 245424 | 1922 |
| <sup>\*</sup> | Paragon 28 Inc. | 91789 | 1882 |
| <sup>\*</sup> | Artivion Inc. | 138672 | 1774 |
| <sup>\*</sup> | AngioDynamics Inc. | 133417 | 1728 |
| <sup>\*</sup> | Surmodics Inc. | 47555 | 1718 |
| <sup>\*</sup> | Senseonics Holdings Inc. | 1533079 | 1702 |
| <sup>\*</sup> | Inogen Inc. | 75842 | 1693 |
| <sup>\*</sup> | PROCEPT BioRobotics Corp. | 38960 | 1671 |
| <sup>\*</sup> | Treace Medical Concepts Inc. | 57181 | 1324 |
| <sup>\*</sup> | Butterfly Network Inc. | 391701 | 1265 |
| <sup>\*</sup> | SI-BONE Inc. | 100406 | 1233 |
| <sup>\*</sup> | Orthofix Medical Inc. | 67974 | 1223 |
| <sup>\*</sup> | OraSure Technologies Inc. | 233684 | 1178 |
| <sup>\*</sup> | Zimvie Inc. | 71821 | 642 |
| <sup>\*</sup> | Pulmonx Corp. | 97520 | 587 |
|  |  |  | **3717483** |
| **Health Care Providers & Services (22.5%)** | **Health Care Providers & Services (22.5%)** | **Health Care Providers & Services (22.5%)** | **Health Care Providers & Services (22.5%)** |
|  | UnitedHealth Group Inc. | 3233558 | 1771214 |
|  | CVS Health Corp. | 4538266 | 462359 |
|  | Elevance Health Inc. | 829655 | 442140 |
|  | Cigna Corp. | 1054723 | 346888 |
|  | Humana Inc. | 437457 | 240558 |
|  | HCA Healthcare Inc. | 793829 | 190694 |
|  | McKesson Corp. | 496828 | 189629 |
| <sup>\*</sup> | Centene Corp. | 1975863 | 171999 |
|  | AmerisourceBergen Corp. | 537363 | 91722 |
|  | Cardinal Health Inc. | 941720 | 75498 |
|  | Laboratory Corp. of America Holdings | 312466 | 75211 |
| <sup>\*</sup> | Molina Healthcare Inc. | 200805 | 67625 |
|  | Quest Diagnostics Inc. | 403009 | 61189 |
| <sup>\*</sup> | Henry Schein Inc. | 470368 | 38062 |
|  | Universal Health Services Inc. Class B | 227220 | 29732 |
| <sup>\*</sup> | Acadia Healthcare Co. Inc. | 314279 | 27990 |
|  | Chemed Corp. | 51477 | 26768 |
|  | Encompass Health Corp. | 344779 | 20163 |
| <sup>\*</sup> | AMN Healthcare Services Inc. | 149658 | 18513 |
| <sup>\*</sup> | HealthEquity Inc. | 291622 | 18512 |
|  | Ensign Group Inc. | 181541 | 17246 |
| <sup>\*</sup> | Guardant Health Inc. | 318164 | 16653 |
| <sup>\*</sup> | LHC Group Inc. | 101845 | 16642 |
| <sup>\*</sup> | Tenet Healthcare Corp. | 355109 | 16399 |
| <sup>\*</sup> | Option Care Health Inc. | 503014 | 15146 |

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| | | | |
|:---|:---|:---|:---|
|  |  | Shares | Market<br> Value<br> ($000) |
| <sup>\*</sup> | DaVita Inc. | 189442 | 13968 |
|  | Premier Inc. Class A | 408277 | 13616 |
| <sup>\*</sup> | agilon health Inc. | 710504 | 12476 |
| <sup>\*</sup> | Amedisys Inc. | 112070 | 10208 |
| <sup>\*</sup> | Progyny Inc. | 254378 | 9318 |
|  | Select Medical Holdings Corp. | 370291 | 9102 |
|  | Patterson Cos. Inc. | 302754 | 8610 |
| <sup>\*</sup> | Oak Street Health Inc. | 375440 | 8117 |
| <sup>\*</sup> | 1Life Healthcare Inc. | 473927 | 8052 |
| <sup>\*</sup> | Signify Health Inc. Class A | 244308 | 6992 |
| <sup>\*</sup> | Surgery Partners Inc. | 233326 | 6605 |
| <sup>\*</sup> | Privia Health Group Inc. | 269545 | 6450 |
| <sup>\*</sup> | Addus HomeCare Corp. | 55407 | 6110 |
| <sup>\*</sup> | AdaptHealth Corp. Class A | 233405 | 5207 |
|  | Owens & Minor Inc. | 250615 | 5165 |
| <sup>\*</sup> | CorVel Corp. | 33183 | 5076 |
| <sup>\*</sup> | R1 RCM Inc. | 503671 | 4558 |
| <sup>\*</sup> | Cross Country Healthcare Inc. | 125769 | 4500 |
| <sup>\*</sup> | Pediatrix Medical Group Inc. | 277114 | 4428 |
| <sup>\*</sup> | Apollo Medical Holdings Inc. | 137137 | 3903 |
| <sup>\*</sup> | Alignment Healthcare Inc. | 292526 | 3891 |
|  | US Physical Therapy Inc. | 44698 | 3862 |
| <sup>\*</sup> | RadNet Inc. | 178727 | 3533 |
| <sup>\*</sup> | ModivCare Inc. | 43632 | 3360 |
|  | National HealthCare Corp. | 50104 | 3088 |
| <sup>\*</sup> | OPKO Health Inc. | 1736654 | 2605 |
| <sup>\*</sup> | 23andMe Holding Co. Class A | 847094 | 2584 |
| <sup>\*</sup> | Hims & Hers Health Inc. | 413156 | 2557 |
| <sup>\*</sup> | Enhabit Inc. | 173063 | 2477 |
| <sup>\*,1</sup> | Fulgent Genetics Inc. | 68007 | 2467 |
| <sup>\*,1</sup> | Invitae Corp. | 773985 | 2299 |
| <sup>\*</sup> | DocGo Inc. | 279358 | 2053 |
| <sup>\*</sup> | Agiliti Inc. | 116123 | 1917 |
| <sup>\*</sup> | Accolade Inc. | 209775 | 1852 |
| <sup>\*</sup> | Brookdale Senior Living Inc. | 582590 | 1835 |
| <sup>\*</sup> | Castle Biosciences Inc. | 76882 | 1814 |
| <sup>\*</sup> | Clover Health Investments Corp. Class A | 1142416 | 1497 |
| <sup>\*</sup> | Community Health Systems Inc. | 424210 | 1455 |
| <sup>\*</sup> | Cano Health Inc. | 561426 | 1067 |
| <sup>\*</sup> | PetIQ Inc. Class A | 89820 | 1066 |
| <sup>\*</sup> | Pennant Group Inc. | 97429 | 1007 |
| <sup>\*</sup> | Joint Corp. | 49946 | 745 |
| <sup>\*</sup> | CareMax Inc. | 165936 | 657 |
| <sup>\*</sup> | Sema4 Holdings Corp. | 392386 | 162 |
| <sup>\*</sup> | Aveanna Healthcare Holdings Inc. | 157399 | 107 |
|  |  |  | **4650970** |
| **Health Care Technology (0.9%)** | **Health Care Technology (0.9%)** | **Health Care Technology (0.9%)** | **Health Care Technology (0.9%)** |
| <sup>\*</sup> | Veeva Systems Inc. Class A | 484271 | 92186 |
| <sup>\*</sup> | Inspire Medical Systems Inc. | 99545 | 24047 |
| <sup>\*</sup> | Teladoc Health Inc. | 558763 | 15930 |
| <sup>\*</sup> | Doximity Inc. Class A | 330181 | 11223 |
| <sup>\*</sup> | Evolent Health Inc. Class A | 285024 | 8206 |
| <sup>\*</sup> | Allscripts Healthcare Solutions Inc. | 382209 | 7239 |
| <sup>\*</sup> | Certara Inc. | 357933 | 6078 |
| <sup>\*</sup> | Phreesia Inc. | 172379 | 4796 |
| <sup>\*</sup> | NextGen Healthcare Inc. | 198722 | 4133 |
| <sup>\*</sup> | Schrodinger Inc. | 202252 | 3640 |
| <sup>\*</sup> | American Well Corp. Class A | 706368 | 2578 |

---

------

---

| | | | |
|:---|:---|:---|:---|
|  |  | Shares | Market<br> Value<br> ($000) |
|  | Simulations Plus Inc. | 55342 | 2246 |
| <sup>\*</sup> | HealthStream Inc. | 84357 | 2143 |
| <sup>\*</sup> | Health Catalyst Inc. | 167430 | 1755 |
| <sup>\*</sup> | Definitive Healthcare Corp. Class A | 121658 | 1383 |
| <sup>\*</sup> | OptimizeRx Corp. | 55154 | 1163 |
| <sup>\*</sup> | GoodRx Holdings Inc. Class A | 252647 | 1102 |
| <sup>\*</sup> | Multiplan Corp. | 655458 | 977 |
|  |  |  | **190825** |
| **Life Sciences Tools & Services (11.9%)** | **Life Sciences Tools & Services (11.9%)** | **Life Sciences Tools & Services (11.9%)** | **Life Sciences Tools & Services (11.9%)** |
|  | Thermo Fisher Scientific Inc. | 1354402 | 758763 |
|  | Danaher Corp. | 2389041 | 653188 |
|  | Agilent Technologies Inc. | 1023309 | 158592 |
| <sup>\*</sup> | IQVIA Holdings Inc. | 644813 | 140582 |
| <sup>\*</sup> | Illumina Inc. | 543817 | 118596 |
| <sup>\*</sup> | Mettler-Toledo International Inc. | 77832 | 114379 |
| <sup>\*</sup> | Waters Corp. | 207014 | 71751 |
|  | PerkinElmer Inc. | 436375 | 60975 |
|  | West Pharmaceutical Services Inc. | 255977 | 60068 |
| <sup>\*</sup> | Avantor Inc. | 2330067 | 51914 |
|  | Bio-Techne Corp. | 542505 | 46107 |
| <sup>\*</sup> | Charles River Laboratories International Inc. | 175936 | 40214 |
| <sup>\*</sup> | Repligen Corp. | 182286 | 32600 |
| <sup>\*</sup> | Bio-Rad Laboratories Inc. Class A | 76621 | 31775 |
|  | Bruker Corp. | 358558 | 24170 |
| <sup>\*</sup> | Medpace Holdings Inc. | 85776 | 18004 |
|  | Azenta Inc. | 259016 | 15595 |
| <sup>\*</sup> | Syneos Health Inc. | 354713 | 12514 |
| <sup>\*</sup> | 10X Genomics Inc. Class A | 263036 | 10169 |
| <sup>\*</sup> | Pacific Biosciences of California Inc. | 739139 | 7946 |
| <sup>\*</sup> | Maravai LifeSciences Holdings Inc. Class A | 387259 | 5762 |
| <sup>\*</sup> | NeoGenomics Inc. | 413680 | 4637 |
| <sup>\*</sup> | CryoPort Inc. | 167439 | 3307 |
| <sup>\*</sup> | Adaptive Biotechnologies Corp. | 344521 | 3025 |
| <sup>\*</sup> | Cytek Biosciences Inc. | 233088 | 3004 |
| <sup>\*</sup> | Sotera Health Co. | 339297 | 2830 |
| <sup>\*</sup> | BioLife Solutions Inc. | 109580 | 2320 |
| <sup>\*,1</sup> | Bionano Genomics Inc. | 994127 | 1998 |
| <sup>\*</sup> | Quanterix Corp. | 123468 | 1642 |
| <sup>\*</sup> | MaxCyte Inc. | 243517 | 1459 |
| <sup>\*</sup> | SomaLogic Inc. | 467763 | 1310 |
| <sup>\*</sup> | Codexis Inc. | 200793 | 1098 |
| <sup>\*</sup> | NanoString Technologies Inc. | 152556 | 1066 |
| <sup>\*</sup> | OmniAb Inc. | 284387 | 1007 |
| <sup>\*</sup> | Seer Inc. Class A | 132810 | 858 |
| <sup>\*</sup> | Quantum-Si Inc. | 294020 | 700 |
| <sup>\*</sup> | Akoya Biosciences Inc. | 19934 | 259 |
| <sup>\*</sup> | Nautilus Biotechnology Inc. | 128696 | 233 |
| <sup>\*,2</sup> | OmniAb Inc. 12.5 Earnout | 22077 |  |
| <sup>\*,2</sup> | OmniAb Inc. 15 Earnout | 22076 |  |
|  |  |  | **2464417** |
| **Pharmaceuticals (27.9%)** | **Pharmaceuticals (27.9%)** | **Pharmaceuticals (27.9%)** | **Pharmaceuticals (27.9%)** |
|  | Johnson & Johnson | 9088624 | 1617775 |
|  | Eli Lilly & Co. | 2791992 | 1036052 |
|  | Pfizer Inc. | 19401251 | 972585 |
|  | Merck & Co. Inc. | 8756977 | 964318 |
|  | Bristol-Myers Squibb Co. | 7380902 | 592539 |
|  | Zoetis Inc. | 1618252 | 249437 |

---

------

---

| | | | |
|:---|:---|:---|:---|
|  |  | Shares | Market<br> Value<br> ($000) |
|  | Royalty Pharma plc Class A | 1208368 | 53132 |
|  | Viatris Inc. | 4191735 | 46235 |
| <sup>\*</sup> | Jazz Pharmaceuticals plc | 216593 | 33986 |
| <sup>\*</sup> | Catalent Inc. | 590809 | 29617 |
|  | Organon & Co. | 879298 | 22879 |
| <sup>\*</sup> | Elanco Animal Health Inc. (XNYS) | 1475698 | 18992 |
| <sup>\*</sup> | Intra-Cellular Therapies Inc. | 294008 | 15941 |
|  | Perrigo Co. plc | 464346 | 14966 |
| <sup>\*</sup> | Prestige Consumer Healthcare Inc. | 171684 | 10552 |
| <sup>\*</sup> | Corcept Therapeutics Inc. | 333159 | 8422 |
| <sup>\*</sup> | Pacira BioSciences Inc. | 158193 | 7633 |
| <sup>\*,1</sup> | Axsome Therapeutics Inc. | 104513 | 7555 |
| <sup>\*,1</sup> | Tilray Brands Inc. | 1855371 | 7180 |
| <sup>\*</sup> | Supernus Pharmaceuticals Inc. | 185182 | 6800 |
| <sup>\*</sup> | Arvinas Inc. | 156530 | 6424 |
| <sup>\*</sup> | Revance Therapeutics Inc. | 279513 | 6068 |
| <sup>\*</sup> | Harmony Biosciences Holdings Inc. | 82168 | 4911 |
| <sup>\*,1</sup> | Cassava Sciences Inc. | 131817 | 4591 |
| <sup>\*</sup> | Ligand Pharmaceuticals Inc. | 58037 | 4231 |
| <sup>\*</sup> | Amphastar Pharmaceuticals Inc. | 135900 | 4008 |
| <sup>\*</sup> | Reata Pharmaceuticals Inc. Class A | 93425 | 3698 |
| <sup>\*</sup> | DICE Therapeutics Inc. | 104283 | 3630 |
| <sup>\*</sup> | Innoviva Inc. | 215775 | 2833 |
| <sup>\*</sup> | Collegium Pharmaceutical Inc. | 112436 | 2459 |
|  | Aclaris Therapeutics Inc. | 161317 | 2455 |
| <sup>\*</sup> | Theravance Biopharma Inc. | 197592 | 2126 |
| <sup>\*</sup> | Pliant Therapeutics Inc. | 113680 | 2090 |
| <sup>\*</sup> | Cara Therapeutics Inc. | 158581 | 1871 |
| <sup>\*</sup> | Nektar Therapeutics Class A | 652296 | 1826 |
| <sup>\*</sup> | Ventyx Biosciences Inc. | 57975 | 1681 |
| <sup>\*,1</sup> | ATAI Life Sciences NV | 411772 | 1454 |
|  | SIGA Technologies Inc. | 153616 | 1410 |
| <sup>\*</sup> | Atea Pharmaceuticals Inc. | 255847 | 1200 |
|  | Tarsus Pharmaceuticals Inc. | 59914 | 1007 |
| <sup>\*</sup> | Fulcrum Therapeutics Inc. | 129648 | 888 |
|  | Phibro Animal Health Corp. Class A | 69821 | 860 |
| <sup>\*</sup> | Amneal Pharmaceuticals Inc. | 330868 | 847 |
| <sup>\*</sup> | Nuvation Bio Inc. | 409253 | 782 |
|  | Cincor Pharma Inc. | 58921 | 695 |
| <sup>\*</sup> | Phathom Pharmaceuticals Inc. | 60066 | 600 |
| <sup>\*</sup> | NGM Biopharmaceuticals Inc. | 96303 | 533 |
|  |  |  | **5781774** |
| **Total Common Stocks (Cost $16,047,257)** | **Total Common Stocks (Cost $16,047,257)** | **Total Common Stocks (Cost $16,047,257)** | **20675139** |

---

------

---

| | | | |
|:---|:---|:---|:---|
|  |  | **Shares** | **Market<br> Value<br> ($000)** |
| **Temporary Cash Investments (0.1%)** | **Temporary Cash Investments (0.1%)** | **Temporary Cash Investments (0.1%)** | **Temporary Cash Investments (0.1%)** |
| **Money Market Fund (0.1%)** | **Money Market Fund (0.1%)** | **Money Market Fund (0.1%)** | **Money Market Fund (0.1%)** |
| <sup>3,4</sup> | Vanguard Market Liquidity Fund, 3.877% **(Cost $27,596)** | 276082 | **27606** |
| **Total Investments (100.0%) (Cost $16,074,853)** | **Total Investments (100.0%) (Cost $16,074,853)** | **Total Investments (100.0%) (Cost $16,074,853)** | **20702745** |
| **Other Assets and Liabilities—Net (0.0%)** | **Other Assets and Liabilities—Net (0.0%)** | **Other Assets and Liabilities—Net (0.0%)** | **(4506)** |
| **Net Assets (100.0%)** | **Net Assets (100.0%)** | **Net Assets (100.0%)** | **20698239** |
| Cost is in $000. | Cost is in $000. | Cost is in $000. | Cost is in $000. |

---

---

| | |
|:---|:---|
| \* | Non-income-producing security. |
| 1 | Includes partial security positions on loan to broker-dealers. The total value of securities on loan is $26,414,000. |
| 2 | Security value determined using significant unobservable inputs. |
| 3 | Affiliated money market fund available only to Vanguard funds and certain trusts and accounts managed by Vanguard. Rate shown is the 7-day yield. |
| 4 | Collateral of $27,582,000 was received for securities on loan. |

---

CVR—Contingent Value Rights.

------

#### Derivative Financial Instruments Outstanding as of Period End

------

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| Over-the-Counter Total Return Swaps | Over-the-Counter Total Return Swaps | Over-the-Counter Total Return Swaps | Over-the-Counter Total Return Swaps | Over-the-Counter Total Return Swaps | Over-the-Counter Total Return Swaps | Over-the-Counter Total Return Swaps |
| Reference Entity | Termination<br> Date | Counterparty | Notional<br> Amount<br> ($000) | Floating<br> Interest Rate<br> Received<br> (Paid)<sup>1</sup><br> (%) | Value and<br> Unrealized<br> Appreciation<br> ($000) | Value and<br> Unrealized<br> (Depreciation)<br> ($000) |
| Alnylam Pharmaceuticals Inc. | 8/31/23 | BANA | &nbsp;&nbsp;&nbsp;5515 | (3.776) |  | &nbsp;&nbsp;(16) |
| Gilead Sciences Inc. | 8/31/23 | BANA | 17566 | (3.776) |  | (50) |
|  |  |  |  |  |  | (66) |

---

1 Based on 1M USD Overnight Bank Funding Rate as of the most recent payment date. Floating interest payment received/paid monthly. <br> 1M—1-month. <br> BANA—Bank of America, N.A.

At November 30, 2022, the counterparties had deposited in segregated accounts securities with a value of $1,308,000 in connection with open over-the-counter swap contracts.

A. Security Valuation: Securities are valued as of the close of trading on the New York Stock Exchange (generally 4 p.m., Eastern time) on the valuation date. Equity securities are valued at the latest quoted sales prices or official closing prices taken from the primary market in which each security trades; such securities not traded on the valuation date are valued at the mean of the latest quoted bid and asked prices. Securities for which market quotations are not readily available, or whose values have been affected by events occurring before the fund's pricing time but after the close of the securities' primary markets, are valued by methods deemed by the valuation designee to represent fair value and subject to oversight by the board of trustees. Investments in Vanguard Market Liquidity Fund are valued at that fund's net asset value.

B. Swap Contracts: The fund has entered into equity swap contracts to earn the total return on selected reference stocks in the fund's target index. Under the terms of the swaps, the fund receives the total return on the referenced stock (i.e., receiving the increase or paying the decrease in value of the selected reference stock and receiving the equivalent of any dividends in respect of the selected referenced stock) over a specified period of time, applied to a notional amount that represents the value of a designated number of shares of the selected reference

------

stock at the beginning of the equity swap contract. The fund also pays a floating rate that is based on short-term interest rates, applied to the notional amount. At the same time, the fund generally invests an amount approximating the notional amount of the swap in high-quality temporary cash investments.

A risk associated with all types of swaps is the possibility that a counterparty may default on its obligation to pay net amounts due to the fund. The fund's maximum amount subject to counterparty risk is the unrealized appreciation on the swap contract. The fund mitigates its counterparty risk by entering into swaps only with a diverse group of prequalified counterparties, monitoring their financial strength, entering into master netting arrangements with its counterparties, and requiring its counterparties to transfer collateral as security for their performance. In the absence of a default, the collateral pledged or received by the fund cannot be repledged, resold, or rehypothecated. In the event of a counterparty's default (including bankruptcy), the fund may terminate any swap contracts with that counterparty, determine the net amount owed by either party in accordance with its master netting arrangements, and sell or retain any collateral held up to the net amount owed to the fund under the master netting arrangements. The swap contracts contain provisions whereby a counterparty may terminate open contracts if the fund's net assets decline below a certain level, triggering a payment by the fund if the fund is in a net liability position at the time of the termination. The payment amount would be reduced by any collateral the fund has pledged. Any securities pledged as collateral for open contracts are noted in the Schedule of Investments. The value of collateral received or pledged is compared daily to the value of the swap contracts exposure with each counterparty, and any difference, if in excess of a specified minimum transfer amount, is adjusted and settled within two business days.

Swaps are valued daily based on market quotations received from independent pricing services or recognized dealers and the change in value is recorded as an asset (liability) and as unrealized appreciation (depreciation) until periodic payments are made or the termination of the swap, at which time realized gain (loss) is recorded.

C. Various inputs may be used to determine the value of the fund's investments and derivatives. These inputs are summarized in three broad levels for financial statement purposes. The inputs or methodologies used to value securities are not necessarily an indication of the risk associated with investing in those securities.

#### Level 1 —Quoted prices in active markets for identical securities.

#### Level 2 —Other significant observable inputs (including quoted prices for similar securities, interest rates, prepayment speeds, credit risk, etc.).
**Level 3—Significant unobservable inputs (including the fund's own assumptions used to determine the fair value of investments). Any investments and derivatives valued with significant unobservable inputs are noted on the Schedule of Investments.**

The following table summarizes the market value of the fund's investments and derivatives as of November 30, 2022, based on the inputs used to value them:

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | Level 1<br> ($000) | &nbsp;&nbsp;&nbsp;Level 2<br> ($000) | &nbsp;&nbsp;&nbsp;Level 3<br> ($000) | &nbsp;&nbsp;&nbsp;Total<br> ($000) |
| **Investments** |  |  |  |  |
| Assets |  |  |  |  |
| Common Stocks | &nbsp;&nbsp;20674481 | &nbsp;&nbsp;&nbsp;78 | &nbsp;&nbsp;&nbsp;580 | &nbsp;&nbsp;&nbsp;20675139 |
| Temporary Cash Investments | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;27606 | &nbsp;&nbsp;&nbsp;— | &nbsp;&nbsp;&nbsp;&nbsp;— | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;27606 |
| Total | 20702087 | &nbsp;&nbsp;&nbsp;78 | &nbsp;&nbsp;&nbsp;580 | &nbsp;&nbsp;&nbsp;20702745 |
| **Derivative Financial Instruments** |  |  |  |  |
| Liabilities |  |  |  |  |
| Swap Contracts | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— | &nbsp;&nbsp;&nbsp;66 | &nbsp;&nbsp;&nbsp;&nbsp;— | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;66 |

---

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** VANGUARD WORLD FUND

- **b. Investment Company Act file number:** 811-01027

- **c. CIK number of Registrant:** 0000052848

- **d. LEI of Registrant:** 549300MP6BT0L4Q61L10

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 100 Vanguard Boulevard

  - **City:** Malvern

  - **State:** PA

  - **Foreign country:** US

  - **Zip / Postal Code:** 19355

  - **Telephone number:** 610-669-1000

**Item A.2. Information about the Series.**

- **a. Name of Series:** VANGUARD HEALTH CARE INDEX FUND

- **b. EDGAR series identifier (if any):** S000004450

- **c. LEI of Series:** 4G9X037GNB6OUK17TK21

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2023-08-31

- **b. Date as of which information is reported:** 2022-11-30

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $20739667178.40

**Total Liabilities:** $22970437.13

**Net Assets:** $20716696741.27

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000012223 | -3.20%               | 8.80%                | 4.68%                |
| Class ID C000012222 | -3.18%               | 8.80%                | 4.67%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $40202379.46             | $-650771912.56                             |
| Month 2  | $68885169.18             | $1499227438.46                             |
| Month 3  | $72865636.11             | $819040942.20                              |

### Schedule of Portfolio Investments

| Name                                              | Title                                       | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)    | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Surgery Partners Inc                              | SURGERY PARTNERS                            | CUSIP: 86881A100<br>LEI: 549300LC82HG33S19I03 | Long             | EC               | CORP              | US        |    171803 | NS      | $4863742.93    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Varex Imaging Corp                                | VAREX IMAGIN                                | CUSIP: 92214X106<br>LEI: 549300CWYWPVCT8E9W67 | Long             | EC               | CORP              | US        |    137139 | NS      | $2912832.36    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Nektar Therapeutics                               | NEKTAR THERAPEUT                            | CUSIP: 640268108<br>LEI: 5299005I24806IOIYE03 | Long             | EC               | CORP              | US        |    636167 | NS      | $1781267.60    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Prevail Therapeutics Inc                          | PREVAIL THERAPEU - CVR                      | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |        78 | NS      | $39.00         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Hologic Inc                                       | HOLOGIC INC                                 | CUSIP: 436440101<br>LEI: 549300DYP6F5ZJL0LB74 | Long             | EC               | CORP              | US        |    863022 | NS      | $65727755.52   | 0.32%             |  |  |  | No            |                  1 | On Loan: No      |
| Bionano Genomics Inc                              | BIONANO GENOMICS                            | CUSIP: 09075F107<br>LEI: 54930086AP7ROH0VJ631 | Long             | EC               | CORP              | US        |    994127 | NS      | $1998195.27    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Chemed Corp                                       | CHEMED CORP                                 | CUSIP: 16359R103<br>LEI: 54930020031IDJT2IM79 | Long             | EC               | CORP              | US        |     51750 | NS      | $26910000.00   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| ABIOMED Inc                                       | ABIOMED INC                                 | CUSIP: 003654100<br>LEI: 5493001EZN4ZTB4Z5887 | Long             | EC               | CORP              | US        |    157749 | NS      | $59595994.71   | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Thermo Fisher Scientific Inc                      | THERMO FISHER                               | CUSIP: 883556102<br>LEI: HCHV7422L5HDJZCRFL38 | Long             | EC               | CORP              | US        |   1354497 | NS      | $758816309.34  | 3.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Sorrento Therapeutics Inc                         | SORRENTO THERAPE                            | CUSIP: 83587F202<br>LEI: 549300RH23PRR3M13410 | Long             | EC               | CORP              | US        |   1339494 | NS      | $1741342.20    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Penumbra Inc                                      | PENUMBRA INC                                | CUSIP: 70975L107<br>LEI: 549300RGE06P3ECANU72 | Long             | EC               | CORP              | US        |    123716 | NS      | $25919739.16   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Avantor Inc                                       | AVANTOR INC                                 | CUSIP: 05352A100<br>LEI: 5493003VM0XB4U8YD238 | Long             | EC               | CORP              | US        |   2111417 | NS      | $47042370.76   | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Anavex Life Sciences Corp                         | ANAVEX LIFE SCIE                            | CUSIP: 032797300<br>LEI: 549300K1I5L8COCQ8W36 | Long             | EC               | CORP              | US        |    266990 | NS      | $2354851.80    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Exelixis Inc                                      | EXELIXIS INC                                | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |   1108898 | NS      | $18939977.84   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Option Care Health Inc                            | OPTION CARE HEAL                            | CUSIP: 68404L201<br>LEI: 549300DI3Q5ACSYJRI17 | Long             | EC               | CORP              | US        |    499238 | NS      | $15032056.18   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| NGM Biopharmaceuticals Inc                        | NGM BIOPHARMACEU                            | CUSIP: 62921N105<br>LEI: 5493008V5DSDZIGQOP17 | Long             | EC               | CORP              | US        |     96303 | NS      | $532555.59     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Zimmer Biomet Holdings Inc                        | ZIMMER BIOMET HO                            | CUSIP: 98956P102<br>LEI: 2P2YLDVPES3BXQ1FRB91 | Long             | EC               | CORP              | US        |    725254 | NS      | $87103005.40   | 0.42%             |  |  |  | No            |                  1 | On Loan: No      |
| Medtronic PLC                                     | MEDTRONIC PLC                               | CUSIP: G5960L103<br>LEI: 549300GX3ZBSQWUXY261 | Long             | EC               | CORP              | US        |   4604302 | NS      | $363924030.08  | 1.76%             |  |  |  | No            |                  1 | On Loan: No      |
| NuVasive Inc                                      | NUVASIVE INC                                | CUSIP: 670704105<br>LEI: 549300C5ZB4NZ6TWM881 | Long             | EC               | CORP              | US        |    179976 | NS      | $6990267.84    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| DICE Therapeutics Inc                             | DICE THERAPEUTI                             | CUSIP: 23345J104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    104283 | NS      | $3630091.23    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Amicus Therapeutics Inc                           | AMICUS THERAPEUT                            | CUSIP: 03152W109<br>LEI: 549300MRD1SMUTNBPQ53 | Long             | EC               | CORP              | US        |    730955 | NS      | $8844555.50    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Sangamo Therapeutics Inc                          | SANGAMO THERAPEU                            | CUSIP: 800677106<br>LEI: 2549006WMRKRC4G32Z67 | Long             | EC               | CORP              | US        |    453357 | NS      | $1659286.62    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Health Catalyst Inc                               | HEALTH CATALYST                             | CUSIP: 42225T107<br>LEI: 549300223PL6GWKVJG92 | Long             | EC               | CORP              | US        |    167430 | NS      | $1754666.40    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Keros Therapeutics Inc                            | KEROS THERAPEUTI                            | CUSIP: 492327101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     49679 | NS      | $2476001.36    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Kiniksa Pharmaceuticals Ltd                       | KINIKSA PHARMA-A                            | CUSIP: G5269C101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    108684 | NS      | $1829151.72    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Align Technology Inc                              | ALIGN TECHNOLOGY                            | CUSIP: 016255101<br>LEI: 549300N5YSE0U3LCP840 | Long             | EC               | CORP              | US        |    259057 | NS      | $50946149.62   | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Phibro Animal Health Corp                         | PHIBRO ANIMAL-A                             | CUSIP: 71742Q106<br>LEI: 549300U24SP4AF2JUX52 | Long             | EC               | CORP              | US        |     69821 | NS      | $859496.51     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Progyny Inc                                       | PROGYNY INC                                 | CUSIP: 74340E103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    254378 | NS      | $9317866.14    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Simulations Plus Inc                              | SIMULATIONS PLUS                            | CUSIP: 829214105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     56600 | NS      | $2297394.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Haemonetics Corp                                  | HAEMONETICS CORP                            | CUSIP: 405024100<br>LEI: 549300ZEL6TXZS6F5F95 | Long             | EC               | CORP              | US        |    177627 | NS      | $15153359.37   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                               | Receive GILEAD SCIENCES Pay Overnight Rate  | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | N/A       |    200000 | NC      | $1874000.00    | 0.01%             |  |  |  | No            |                  2 | On Loan: No      |
| Deciphera Pharmaceuticals Inc                     | DECIPHERA PHARMA                            | CUSIP: 24344T101<br>LEI: 529900QR4WAPYY0CBF25 | Long             | EC               | CORP              | US        |    136798 | NS      | $2176456.18    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Quest Diagnostics Inc                             | QUEST DIAGNOSTIC                            | CUSIP: 74834L100<br>LEI: 8MCWUBXQ0WE04KMXBX50 | Long             | EC               | CORP              | US        |    405961 | NS      | $61637058.63   | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Innoviva Inc                                      | INNOVIVA INC                                | CUSIP: 45781M101<br>LEI: 549300ACOX4QTBES6535 | Long             | EC               | CORP              | US        |    215775 | NS      | $2833125.75    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Celldex Therapeutics Inc                          | CELLDEX THERAPEU                            | CUSIP: 15117B202<br>LEI: 529900F018DMYWH38923 | Long             | EC               | CORP              | US        |    129920 | NS      | $4818732.80    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Pediatrix Medical Group Inc                       | PEDIATRIX MEDICA                            | CUSIP: 58502B106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    288204 | NS      | $4605499.92    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| BioCryst Pharmaceuticals Inc                      | BIOCRYST PHARM                              | CUSIP: 09058V103<br>LEI: 549300Z0INP1Z5NP6J59 | Long             | EC               | CORP              | US        |    642066 | NS      | $8578001.76    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Envista Holdings Corp                             | ENVISTA HOLDINGS                            | CUSIP: 29415F104<br>LEI: 549300BX623VURJZ5269 | Long             | EC               | CORP              | US        |    561919 | NS      | $19172676.28   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Prothena Corp PLC                                 | PROTHENA CORP PL                            | CUSIP: G72800108<br>LEI: 5299009ZXQ8NIIJ8OL30 | Long             | EC               | CORP              | US        |    113370 | NS      | $7086758.70    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| United Therapeutics Corp                          | UNITED THERAPEUT                            | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |    156676 | NS      | $43852045.64   | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Amgen Inc                                         | AMGEN INC                                   | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |   1848331 | NS      | $529361998.40  | 2.56%             |  |  |  | No            |                  1 | On Loan: No      |
| Halozyme Therapeutics Inc                         | HALOZYME THERAPE                            | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |    477875 | NS      | $27363122.50   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| ImmunoGen Inc                                     | IMMUNOGEN INC                               | CUSIP: 45253H101<br>LEI: 54930084U0R1OP766Y02 | Long             | EC               | CORP              | US        |    688724 | NS      | $3574477.56    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Sage Therapeutics Inc                             | SAGE THERAPEUTIC                            | CUSIP: 78667J108<br>LEI: 5493000JX4BJS9W6CN35 | Long             | EC               | CORP              | US        |    183747 | NS      | $7540976.88    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Perrigo Co PLC                                    | PERRIGO CO PLC                              | CUSIP: G97822103<br>LEI: 549300IFOQS6R1QLY196 | Long             | EC               | CORP              | US        |    465910 | NS      | $15016279.30   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Axsome Therapeutics Inc                           | AXSOME THERAPEUT                            | CUSIP: 05464T104<br>LEI: 549300EXGR0XLRJEIB95 | Long             | EC               | CORP              | US        |    101491 | NS      | $7336784.39    | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Amedisys Inc                                      | AMEDISYS INC                                | CUSIP: 023436108<br>LEI: 5299001RBS9GK9STN379 | Long             | EC               | CORP              | US        |    112624 | NS      | $10258920.16   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| EQRx Inc                                          | EQRX INC                                    | CUSIP: 26886C107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    511138 | NS      | $1921878.88    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| AbbVie Inc                                        | ABBVIE INC                                  | CUSIP: 00287Y109<br>LEI: FR5LCKFTG8054YNNRU85 | Long             | EC               | CORP              | US        |   6114480 | NS      | $985531886.40  | 4.76%             |  |  |  | No            |                  1 | On Loan: No      |
| CareMax Inc                                       | CAREMAX INC                                 | CUSIP: 14171W103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    165936 | NS      | $657106.56     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Pacific Biosciences of California Inc             | PACIFIC BIOSCIEN                            | CUSIP: 69404D108<br>LEI: 529900F1BWRE1M0KZN89 | Long             | EC               | CORP              | US        |    744356 | NS      | $8001827.00    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| ATAI Life Sciences NV                             | ATAI LIFE SCIENC                            | CUSIP: N0731H103<br>LEI: 391200Z8UWPJSNBNCA11 | Long             | EC               | CORP              | US        |    411772 | NS      | $1453555.16    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Nautilus Biotechnology Inc                        | NAUTILUS BIOTECH                            | CUSIP: 63909J108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    128696 | NS      | $232939.76     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Blueprint Medicines Corp                          | BLUEPRINT MEDICI                            | CUSIP: 09627Y109<br>LEI: 5299004CC60O9T5HVM83 | Long             | EC               | CORP              | US        |    205658 | NS      | $9828395.82    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Patterson Cos Inc                                 | PATTERSON COS                               | CUSIP: 703395103<br>LEI: YM48Q2087CUE26GWEK09 | Long             | EC               | CORP              | US        |    304935 | NS      | $8672351.40    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Doximity Inc                                      | DOXIMITY INC-A                              | CUSIP: 26622P107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    323277 | NS      | $10988185.23   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Accolade Inc                                      | ACCOLADE INC                                | CUSIP: 00437E102<br>LEI: 549300PHKG8J7A22NF08 | Long             | EC               | CORP              | US        |    199278 | NS      | $1759624.74    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| BioLife Solutions Inc                             | BIOLIFE SOLUTION                            | CUSIP: 09062W204<br>LEI: 549300G2IVCMC2TJDW72 | Long             | EC               | CORP              | US        |    109580 | NS      | $2319808.60    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Revance Therapeutics Inc                          | REVANCE THERAPEU                            | CUSIP: 761330109<br>LEI: 549300N33TFDZHS81H11 | Long             | EC               | CORP              | US        |    279513 | NS      | $6068227.23    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Inogen Inc                                        | INOGEN INC                                  | CUSIP: 45780L104<br>LEI: 549300J8WJIVTOJ8IH97 | Long             | EC               | CORP              | US        |     75842 | NS      | $1692793.44    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Cullinan Oncology Inc                             | CULLINAN ONCOLOG                            | CUSIP: 230031106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     44681 | NS      | $555384.83     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Harmony Biosciences Holdings Inc                  | HARMONY BIOSCIE                             | CUSIP: 413197104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     81304 | NS      | $4859540.08    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Seer Inc                                          | SEER INC                                    | CUSIP: 81578P106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    132810 | NS      | $857952.60     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Stryker Corp                                      | STRYKER CORP                                | CUSIP: 863667101<br>LEI: 5493002F0SC4JTBU5137 | Long             | EC               | CORP              | US        |   1177819 | NS      | $275480085.91  | 1.33%             |  |  |  | No            |                  1 | On Loan: No      |
| Xencor Inc                                        | XENCOR INC                                  | CUSIP: 98401F105<br>LEI: 549300V5IF65437JKG30 | Long             | EC               | CORP              | US        |    194571 | NS      | $5782650.12    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Orthofix Medical Inc                              | ORTHOFIX MEDICAL                            | CUSIP: 68752M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     67974 | NS      | $1222852.26    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Reata Pharmaceuticals Inc                         | REATA PHARMACE-A                            | CUSIP: 75615P103<br>LEI: 5299005F094GH9QDDD80 | Long             | EC               | CORP              | US        |     92116 | NS      | $3645951.28    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytek Biosciences Inc                             | CYTEK BIOSCIENCE                            | CUSIP: 23285D109<br>LEI: 549300K2J28BOC6FBO89 | Long             | EC               | CORP              | US        |    233088 | NS      | $3004504.32    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| MiMedx Group Inc                                  | MIMEDX GROUP INC                            | CUSIP: 602496101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    249075 | NS      | $809493.75     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| ResMed Inc                                        | RESMED INC                                  | CUSIP: 761152107<br>LEI: 529900T3QE5253CCXF22 | Long             | EC               | CORP              | US        |    506211 | NS      | $116529772.20  | 0.56%             |  |  |  | No            |                  1 | On Loan: No      |
| Kymera Therapeutics Inc                           | KYMERA THERAPEUT                            | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    116228 | NS      | $3368287.44    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Premier Inc                                       | PREMIER INC-CL A                            | CUSIP: 74051N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    408277 | NS      | $13616037.95   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Sarepta Therapeutics Inc                          | SAREPTA THERAPEU                            | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |    287913 | NS      | $35358595.53   | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Surmodics Inc                                     | SURMODICS INC                               | CUSIP: 868873100<br>LEI: 549300H76KXCAAGUS878 | Long             | EC               | CORP              | US        |     47555 | NS      | $1718162.15    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Waters Corp                                       | WATERS CORP                                 | CUSIP: 941848103<br>LEI: 5T547R1474YC9HOD8Q74 | Long             | EC               | CORP              | US        |    208507 | NS      | $72268526.20   | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Cano Health Inc                                   | CANO HEALTH INC                             | CUSIP: 13781Y103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    501848 | NS      | $953511.20     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| TG Therapeutics Inc                               | TG THERAPEUTICS                             | CUSIP: 88322Q108<br>LEI: 529900X21UKABN9NJ529 | Long             | EC               | CORP              | US        |    472408 | NS      | $4166638.56    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Tango Therapeutics Inc                            | TANGO THERAPEUTI                            | CUSIP: 87583X109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    104898 | NS      | $787783.98     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Ligand Pharmaceuticals Inc                        | LIGAND PHARM                                | CUSIP: 53220K504<br>LEI: 5493008K7TB0IKP37H79 | Long             | EC               | CORP              | US        |     58037 | NS      | $4230897.30    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Coherus Biosciences Inc                           | COHERUS BIOSCIEN                            | CUSIP: 19249H103<br>LEI: 5493007IL8W5MV932D26 | Long             | EC               | CORP              | US        |    211926 | NS      | $1453812.36    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Twist Bioscience Corp                             | TWIST BIOSCIENCE                            | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |    184287 | NS      | $5040249.45    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| DaVita Inc                                        | DAVITA INC                                  | CUSIP: 23918K108<br>LEI: M2XHYMU3TZNEZURC6H66 | Long             | EC               | CORP              | US        |    196358 | NS      | $14477475.34   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Alignment Healthcare Inc                          | ALIGNMENT HEALTH                            | CUSIP: 01625V104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    292526 | NS      | $3890595.80    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Enanta Pharmaceuticals Inc                        | ENANTA PHARMACEU                            | CUSIP: 29251M106<br>LEI: 529900SSN4DODDQSN594 | Long             | EC               | CORP              | US        |     67687 | NS      | $2964013.73    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| AdaptHealth Corp                                  | ADAPTHEALTH CORP                            | CUSIP: 00653Q102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    233405 | NS      | $5207265.55    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Intra-Cellular Therapies Inc                      | INTRA-CELLULAR T                            | CUSIP: 46116X101<br>LEI: 5299002U2KGF193IJA20 | Long             | EC               | CORP              | US        |    294008 | NS      | $15941113.76   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| IVERIC bio Inc                                    | IVERIC BIO INC                              | CUSIP: 46583P102<br>LEI: 549300GZXI59U71XPM70 | Long             | EC               | CORP              | US        |    283547 | NS      | $6697380.14    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Medpace Holdings Inc                              | MEDPACE HOLDINGS                            | CUSIP: 58506Q109<br>LEI: 549300H8TYEUVTW14A54 | Long             | EC               | CORP              | US        |     88707 | NS      | $18618712.23   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Avidity Biosciences Inc                           | AVIDITY BIOSCIEN                            | CUSIP: 05370A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    128628 | NS      | $1497229.92    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Certara Inc                                       | CERTARA INC                                 | CUSIP: 15687V109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    357933 | NS      | $6077702.34    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| OPKO Health Inc                                   | OPKO HEALTH                                 | CUSIP: 68375N103<br>LEI: 529900A4S2D4OGOJLL02 | Long             | EC               | CORP              | US        |   1539212 | NS      | $2308818.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Phreesia Inc                                      | PHREESIA INC                                | CUSIP: 71944F106<br>LEI: 5493000HHF8NU4QOCG53 | Long             | EC               | CORP              | US        |    170306 | NS      | $4737912.92    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Hims & Hers Health Inc                            | HIMS & HERS HEAL                            | CUSIP: 433000106<br>LEI: 549300ZQ4ZUYSAAX6P59 | Long             | EC               | CORP              | US        |    413156 | NS      | $2557435.64    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Bristol-Myers Squibb Co                           | BRISTOL-MYER SQB                            | CUSIP: 110122108<br>LEI: HLYYNH7UQUORYSJQCN42 | Long             | EC               | CORP              | US        |   7366173 | NS      | $591356368.44  | 2.85%             |  |  |  | No            |                  1 | On Loan: No      |
| Cigna Corp                                        | CIGNA CORP                                  | CUSIP: 125523100<br>LEI: 549300VIWYMSIGT1U456 | Long             | EC               | CORP              | US        |   1097784 | NS      | $361050179.76  | 1.74%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvalent Inc                                      | NUVALENT INC-A                              | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     36639 | NS      | $1204690.32    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| OmniAb Inc                                        | AVISTA P-CLASS A                            | CUSIP: G07247102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    284387 | NS      | $1006729.98    | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| IQVIA Holdings Inc                                | IQVIA HOLDINGS I                            | CUSIP: 46266C105<br>LEI: 549300W3R20NM4KQPH86 | Long             | EC               | CORP              | US        |    655067 | NS      | $142817707.34  | 0.69%             |  |  |  | No            |                  1 | On Loan: No      |
| Rocket Pharmaceuticals Inc                        | ROCKET PHARMACEU                            | CUSIP: 77313F106<br>LEI: 549300R7VV82YUIN4Y93 | Long             | EC               | CORP              | US        |    187707 | NS      | $3543908.16    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Arrowhead Pharmaceuticals Inc                     | ARROWHEAD PHARMA                            | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |    349508 | NS      | $11254157.60   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Adaptive Biotechnologies Corp                     | ADAPTIVE BIOTECH                            | CUSIP: 00650F109<br>LEI: 549300ZTF7OT1FW66Q96 | Long             | EC               | CORP              | US        |    344521 | NS      | $3024894.38    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| FibroGen Inc                                      | FIBROGEN INC                                | CUSIP: 31572Q808<br>LEI: 549300Q914ULWWY95822 | Long             | EC               | CORP              | US        |    305079 | NS      | $4383985.23    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Regeneron Pharmaceuticals Inc                     | REGENERON PHARM                             | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |    373819 | NS      | $280999742.30  | 1.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Sana Biotechnology Inc                            | SANA BIOTECHNOLO                            | CUSIP: 799566104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    298698 | NS      | $1490503.02    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Arvinas Inc                                       | ARVINAS INC                                 | CUSIP: 04335A105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    156530 | NS      | $6423991.20    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| ViewRay Inc                                       | VIEWRAY INC                                 | CUSIP: 92672L107<br>LEI: 5493006XTUBSKFU3W106 | Long             | EC               | CORP              | US        |    471366 | NS      | $2271984.12    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| STAAR Surgical Co                                 | STAAR SURGICAL                              | CUSIP: 852312305<br>LEI: 5299006LRHI7OJ8BY308 | Long             | EC               | CORP              | US        |    140993 | NS      | $8052110.23    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Recursion Pharmaceuticals Inc                     | RECURSION PHAR-A                            | CUSIP: 75629V104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    169462 | NS      | $1592942.80    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| agilon health Inc                                 | AGILON HEALTH IN                            | CUSIP: 00857U107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    704592 | NS      | $12372635.52   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                               | Receive ALNYLAM PHARMACE Pay Overnight Rate | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | N/A       |     25000 | NC      | $333250.00     | 0.00%             |  |  |  | No            |                  2 | On Loan: No      |
| Codexis Inc                                       | CODEXIS INC                                 | CUSIP: 192005106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    200793 | NS      | $1098337.71    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| DENTSPLY SIRONA Inc                               | DENTSPLY SIRONA                             | CUSIP: 24906P109<br>LEI: 9NHEHR1SOZCYXDO8HO28 | Long             | EC               | CORP              | US        |    746590 | NS      | $22591813.40   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Bridgebio Pharma Inc                              | BRIDGEBIO PHARMA                            | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |    227699 | NS      | $2133539.63    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Outset Medical Inc                                | OUTSET MEDICAL I                            | CUSIP: 690145107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    140242 | NS      | $2956301.36    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Enovis Corp                                       | ENOVIS CORP                                 | CUSIP: 194014502<br>LEI: 635400OP2DYYYMOIYL17 | Long             | EC               | CORP              | US        |    168061 | NS      | $9097141.93    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Intercept Pharmaceuticals Inc                     | INTERCEPT PHARMA                            | CUSIP: 45845P108<br>LEI: 254900JMB8TX5P688V24 | Long             | EC               | CORP              | US        |     81122 | NS      | $1209529.02    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Ocugen Inc                                        | OCUGEN INC                                  | CUSIP: 67577C105<br>LEI: 549300JVNUI9CXWJLR09 | Long             | EC               | CORP              | US        |    737828 | NS      | $1151011.68    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Nurix Therapeutics Inc                            | NURIX THERAPEUTI                            | CUSIP: 67080M103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    114758 | NS      | $1421851.62    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| HCA Healthcare Inc                                | HCA HEALTHCARE I                            | CUSIP: 40412C101<br>LEI: 529900PH4ZGUH2MNEU89 | Long             | EC               | CORP              | US        |    818159 | NS      | $196538154.98  | 0.95%             |  |  |  | No            |                  1 | On Loan: No      |
| Bruker Corp                                       | BRUKER CORP                                 | CUSIP: 116794108<br>LEI: LEBZ6VLQ6I8XB1NHVY15 | Long             | EC               | CORP              | US        |    361830 | NS      | $24390960.30   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Cardiovascular Systems Inc                        | CARDIOVASCULAR S                            | CUSIP: 141619106<br>LEI: 549300NUBWKJMNMQ3287 | Long             | EC               | CORP              | US        |    139622 | NS      | $1956104.22    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| AngioDynamics Inc                                 | ANGIODYNAMICS IN                            | CUSIP: 03475V101<br>LEI: 549300W3VKC5ZKMO8C28 | Long             | EC               | CORP              | US        |    133417 | NS      | $1727750.15    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| PROCEPT BioRobotics Corp                          | PROCEPT BIOROBOT                            | CUSIP: 74276L105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     37840 | NS      | $1623336.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| PMV Pharmaceuticals Inc                           | PMV PHARMACEUTIC                            | CUSIP: 69353Y103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     69752 | NS      | $696124.96     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| BioMarin Pharmaceutical Inc                       | BIOMARIN PHARMAC                            | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |    639881 | NS      | $64615183.38   | 0.31%             |  |  |  | No            |                  1 | On Loan: No      |
| Vanguard Cmt Funds-Vanguard Market Liquidity Fund | Vanguard Market Liquidity Fund              | CUSIP: N/A<br>LEI: 1I6HV0TLSTR3A4XQ6L78       | Long             | STIV             | CORP              | US        |    269908 | NS      | $26988095.12   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Illumina Inc                                      | ILLUMINA INC                                | CUSIP: 452327109<br>LEI: SQ95QG8SR5Q56LSNF682 | Long             | EC               | CORP              | US        |    543540 | NS      | $118535203.20  | 0.57%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen Inc                                        | BIOGEN INC                                  | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |    506653 | NS      | $154615296.01  | 0.75%             |  |  |  | No            |                  1 | On Loan: No      |
| Cooper Cos Inc/The                                | COOPER COS INC                              | CUSIP: 216648402<br>LEI: QJKMVPIGLH7530PCUE20 | Long             | EC               | CORP              | US        |    170740 | NS      | $54013599.00   | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Century Therapeutics Inc                          | CENTURY THERAPEU                            | CUSIP: 15673T100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     40551 | NS      | $425785.50     | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| Merck & Co Inc                                    | MERCK & CO                                  | CUSIP: 58933Y105<br>LEI: 4YV9Y5M8S0BRK1RP0397 | Long             | EC               | CORP              | US        |   8749292 | NS      | $963472035.04  | 4.65%             |  |  |  | No            |                  1 | On Loan: No      |
| Ventyx Biosciences Inc                            | VENTYX BIOSCIENC                            | CUSIP: 92332V107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     57975 | NS      | $1680695.25    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Organon & Co                                      | ORGANON & CO                                | CUSIP: 68622V106<br>LEI: 549300AMCKY57OK2CO56 | Long             | EC               | CORP              | US        |    877105 | NS      | $22822272.10   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| National HealthCare Corp                          | NATL HEALTHCARE                             | CUSIP: 635906100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     50104 | NS      | $3088410.56    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| HealthEquity Inc                                  | HEALTHEQUITY INC                            | CUSIP: 42226A107<br>LEI: 529900LRJU1RAFQHM467 | Long             | EC               | CORP              | US        |    291622 | NS      | $18512164.56   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Azenta Inc                                        | AZENTA INC                                  | CUSIP: 114340102<br>LEI: 35ZN6X1ANPH25YN32Y17 | Long             | EC               | CORP              | US        |    259882 | NS      | $15647495.22   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Cutera Inc                                        | CUTERA INC                                  | CUSIP: 232109108<br>LEI: 529900NPKPEWJWR21Z42 | Long             | EC               | CORP              | US        |     50256 | NS      | $2391180.48    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Theravance Biopharma Inc                          | THERAVANCE B                                | CUSIP: G8807B106<br>LEI: 5493007VTSXP4Z6MIW52 | Long             | EC               | CORP              | US        |    197592 | NS      | $2126089.92    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| ModivCare Inc                                     | MODIVCARE INC                               | CUSIP: 60783X104<br>LEI: 549300EFZIFW7F7I0Q28 | Long             | EC               | CORP              | US        |     43632 | NS      | $3359664.00    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Emergent BioSolutions Inc                         | EMERGENT BIOSOLU                            | CUSIP: 29089Q105<br>LEI: 549300YW6TUOX8BE5103 | Long             | EC               | CORP              | US        |    155467 | NS      | $1912244.10    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Baxter International Inc                          | BAXTER INTL INC                             | CUSIP: 071813109<br>LEI: J5OIVXX3P24RJRW5CK77 | Long             | EC               | CORP              | US        |   1741860 | NS      | $98467345.80   | 0.48%             |  |  |  | No            |                  1 | On Loan: No      |
| RadNet Inc                                        | RADNET INC                                  | CUSIP: 750491102<br>LEI: 529900RECG94V2IZJ970 | Long             | EC               | CORP              | US        |    175579 | NS      | $3471196.83    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| GoodRx Holdings Inc                               | GOODRX HOLDIN-A                             | CUSIP: 38246G108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    241436 | NS      | $1052660.96    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Sotera Health Co                                  | SOTERA HEALTH CO                            | CUSIP: 83601L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    339297 | NS      | $2829736.98    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| US Physical Therapy Inc                           | US PHYSICAL THER                            | CUSIP: 90337L108<br>LEI: 529900KL1UXQYFIOMY96 | Long             | EC               | CORP              | US        |     44698 | NS      | $3862354.18    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Myovant Sciences Ltd                              | MYOVANT SCIENCES                            | CUSIP: G637AM102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    147796 | NS      | $3969800.56    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| 2seventy bio Inc                                  | 2SEVENTY BIO                                | CUSIP: 901384107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    125081 | NS      | $1960019.27    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| MeiraGTx Holdings plc                             | MEIRAGTX HOLDING                            | CUSIP: G59665102<br>LEI: 54930007YV6NYIOGFZ57 | Long             | EC               | CORP              | US        |     91049 | NS      | $560861.84     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| SIGA Technologies Inc                             | SIGA TECH INC                               | CUSIP: 826917106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    153616 | NS      | $1410194.88    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Encompass Health Corp                             | ENCOMPASS HEALTH                            | CUSIP: 29261A100<br>LEI: 549300FVRPM9DRQZRG64 | Long             | EC               | CORP              | US        |    345669 | NS      | $20214723.12   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| OraSure Technologies Inc                          | ORASURE TECH                                | CUSIP: 68554V108<br>LEI: 529900GNNJPNM4XHXQ77 | Long             | EC               | CORP              | US        |    233684 | NS      | $1177767.36    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Protagonist Therapeutics Inc                      | PROTAGONIST THER                            | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    127749 | NS      | $1010494.59    | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| RAPT Therapeutics Inc                             | RAPT THERAPEUTIC                            | CUSIP: 75382E109<br>LEI: 549300MB473BIU78ES48 | Long             | EC               | CORP              | US        |     99104 | NS      | $1752158.72    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| IGM Biosciences Inc                               | IGM BIOSCIENCES                             | CUSIP: 449585108<br>LEI: 5493008XCQES2N0VY969 | Long             | EC               | CORP              | US        |     33816 | NS      | $744290.16     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Charles River Laboratories International Inc      | CHARLES RIVER LA                            | CUSIP: 159864107<br>LEI: 549300BSQ0R4UZ5KX287 | Long             | EC               | CORP              | US        |    175936 | NS      | $40213691.52   | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Zimvie Inc                                        | ZIMVIE INC                                  | CUSIP: 98888T107<br>LEI: 549300GFKURT1J6XR665 | Long             | EC               | CORP              | US        |     71821 | NS      | $642079.74     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Avid Bioservices Inc                              | AVID BIOSERVICES                            | CUSIP: 05368M106<br>LEI: 549300GRUS3ZMGP8MX22 | Long             | EC               | CORP              | US        |    214055 | NS      | $3352101.30    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| NeoGenomics Inc                                   | NEOGENOMICS INC                             | CUSIP: 64049M209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    408281 | NS      | $4576830.01    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Inspire Medical Systems Inc                       | INSPIRE MEDICAL                             | CUSIP: 457730109<br>LEI: 549300XQQCQ7HCJKTW25 | Long             | EC               | CORP              | US        |     95507 | NS      | $23071625.99   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Butterfly Network Inc                             | BUTTERFLY NETWOR                            | CUSIP: 124155102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    391701 | NS      | $1265194.23    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Zentalis Pharmaceuticals Inc                      | ZENTALIS PHARMAC                            | CUSIP: 98943L107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    156391 | NS      | $3459368.92    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Axonics Inc                                       | AXONICS INC                                 | CUSIP: 05465P101<br>LEI: 549300LJY4X7N57VJL05 | Long             | EC               | CORP              | US        |    130219 | NS      | $8917397.12    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Teleflex Inc                                      | TELEFLEX INC                                | CUSIP: 879369106<br>LEI: UUL85LWXB4NGSWWXIQ25 | Long             | EC               | CORP              | US        |    162380 | NS      | $38016405.60   | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Immunovant Inc                                    | IMMUNOVANT INC                              | CUSIP: 45258J102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    133534 | NS      | $1750630.74    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Ultragenyx Pharmaceutical Inc                     | ULTRAGENYX PHARM                            | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |    229836 | NS      | $8343046.80    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Relay Therapeutics Inc                            | RELAY THERAPEUTI                            | CUSIP: 75943R102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    272103 | NS      | $5055673.74    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Geron Corp                                        | GERON CORP-WRT                              | CUSIP: N/A<br>LEI: 549300T282D7Z2YESL90       | Long             | EC               | CORP              | US        |    152449 | NS      | $77748.99      | 0.00%             |  |  |  | No            |                  2 | On Loan: No      |
| Maravai LifeSciences Holdings Inc                 | MARAVAI LIFESC-A                            | CUSIP: 56600D107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    387259 | NS      | $5762413.92    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Community Health Systems Inc                      | COMMUNITY HEALTH                            | CUSIP: 203668108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    424210 | NS      | $1455040.30    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Allscripts Healthcare Solutions Inc               | ALLSCRIPTS HEALT                            | CUSIP: 01988P108<br>LEI: Y68YJHVB1GU4TAU3C223 | Long             | EC               | CORP              | US        |    400905 | NS      | $7593140.70    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Adicet Bio Inc                                    | ADICET BIO INC                              | CUSIP: 007002108<br>LEI: 549300VRD2QO80WBOP18 | Long             | EC               | CORP              | US        |     61581 | NS      | $1119542.58    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Allogene Therapeutics Inc                         | ALLOGENE THERAPE                            | CUSIP: 019770106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    296735 | NS      | $2925807.10    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Atara Biotherapeutics Inc                         | ATARA BIOTHERAPE                            | CUSIP: 046513107<br>LEI: 549300WBXUXZRE03MS38 | Long             | EC               | CORP              | US        |    270717 | NS      | $1226348.01    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Heska Corp                                        | HESKA CORP                                  | CUSIP: 42805E306<br>LEI: 529900O1OR2EB7L0HY27 | Long             | EC               | CORP              | US        |     35411 | NS      | $2278697.85    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Agenus Inc                                        | AGENUS INC                                  | CUSIP: 00847G705<br>LEI: 529900NDQQGU5H4UJK81 | Long             | EC               | CORP              | US        |    840170 | NS      | $2268459.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| 10X Genomics Inc                                  | 10X GENOMICS I-A                            | CUSIP: 88025U109<br>LEI: 5493003Z6741WNLG7H43 | Long             | EC               | CORP              | US        |    292376 | NS      | $11303256.16   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Erasca Inc                                        | ERASCA INC                                  | CUSIP: 29479A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    103650 | NS      | $782557.50     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcutis Biotherapeutics Inc                       | ARCUTIS BIOTHERA                            | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    141410 | NS      | $2436494.30    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Pfizer Inc                                        | PFIZER INC                                  | CUSIP: 717081103<br>LEI: 765LHXWGK1KXCLTFYQ30 | Long             | EC               | CORP              | US        |  19414334 | NS      | $973240563.42  | 4.70%             |  |  |  | No            |                  1 | On Loan: No      |
| Aveanna Healthcare Holdings Inc                   | AVEANNA HEALTHCA                            | CUSIP: 05356F105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    157399 | NS      | $106795.22     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Enhabit Inc                                       | ENHABIT INC                                 | CUSIP: 29332G102<br>LEI: 549300RFQ78SLDFSHF49 | Long             | EC               | CORP              | US        |    173063 | NS      | $2476531.53    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| NanoString Technologies Inc                       | NANOSTRING TECHN                            | CUSIP: 63009R109<br>LEI: 549300G4CK0Y3WRDMY89 | Long             | EC               | CORP              | US        |    152556 | NS      | $1066366.44    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| LivaNova PLC                                      | LIVANOVA PLC                                | CUSIP: G5509L101<br>LEI: 2138001K2FX6SHK2B339 | Long             | EC               | CORP              | US        |    185483 | NS      | $10270193.71   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Sema4 Holdings Corp                               | SEMA4 HOLDINGS C                            | CUSIP: 81663L101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    392386 | NS      | $162526.28     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Artivion Inc                                      | ARTIVION INC                                | CUSIP: 228903100<br>LEI: 549300YTKV8DMSMG6K81 | Long             | EC               | CORP              | US        |    138672 | NS      | $1773614.88    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| ACADIA Pharmaceuticals Inc                        | ACADIA PHARMACEU                            | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |    417713 | NS      | $6507968.54    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Cara Therapeutics Inc                             | CARA THERAPEUTIC                            | CUSIP: 140755109<br>LEI: 549300COVOY41P0GZ881 | Long             | EC               | CORP              | US        |    158581 | NS      | $1871255.80    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Ensign Group Inc/The                              | ENSIGN GROUP INC                            | CUSIP: 29358P101<br>LEI: 5493003K4HEEA8Q0BC72 | Long             | EC               | CORP              | US        |    182450 | NS      | $17332750.00   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| SomaLogic Inc                                     | SOMALOGIC INC                               | CUSIP: 83444K105<br>LEI: 549300D3W3Q8CN30YO25 | Long             | EC               | CORP              | US        |    467763 | NS      | $1309736.40    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| UCB SA                                            | UCB SA - CVR 31/12/2023 (Zogenix Inc Acq)   | CUSIP: N/A<br>LEI: 2138008J191VLSGY5A09       | Long             | EC               | CORP              | BE        |     93751 | NS      | $187502.00     | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Mesa Laboratories Inc                             | MESA LABS                                   | CUSIP: 59064R109<br>LEI: 549300ZCG738WLX8ZW79 | Long             | EC               | CORP              | US        |     18325 | NS      | $3100040.25    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Editas Medicine Inc                               | EDITAS MEDICINE                             | CUSIP: 28106W103<br>LEI: 5299000AON4Q9NT2JE42 | Long             | EC               | CORP              | US        |    236635 | NS      | $2508331.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Elevance Health Inc                               | ELEVANCE HEALTH                             | CUSIP: 036752103<br>LEI: 8MYN82XMYQH89CTMTH67 | Long             | EC               | CORP              | US        |    834205 | NS      | $444564528.60  | 2.15%             |  |  |  | No            |                  1 | On Loan: No      |
| PerkinElmer Inc                                   | PERKINELMER INC                             | CUSIP: 714046109<br>LEI: 549300IKL1SDPFI7N655 | Long             | EC               | CORP              | US        |    436375 | NS      | $60974678.75   | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Vanda Pharmaceuticals Inc                         | VANDA PHARMACEUT                            | CUSIP: 921659108<br>LEI: 529900AY8VOOQBKJ0O70 | Long             | EC               | CORP              | US        |    196865 | NS      | $2147797.15    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Catalent Inc                                      | CATALENT INC                                | CUSIP: 148806102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    589328 | NS      | $29543012.64   | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Omniab Inc/old                                    | OMNIAB INC - 12.5                           | CUSIP: 68218J202<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     22076 | NS      | $0.22          | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| PetIQ Inc                                         | PETIQ INC                                   | CUSIP: 71639T106<br>LEI: 549300GROACFGKVYOX14 | Long             | EC               | CORP              | US        |     89820 | NS      | $1066163.40    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| AnaptysBio Inc                                    | ANAPTYSBIO INC                              | CUSIP: 032724106<br>LEI: 529900HH4WQT03IG1A12 | Long             | EC               | CORP              | US        |     58985 | NS      | $1629755.55    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Evolent Health Inc                                | EVOLENT HEALTH-A                            | CUSIP: 30050B101<br>LEI: 549300CZOCFHQ2BBTR11 | Long             | EC               | CORP              | US        |    268837 | NS      | $7739817.23    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Lantheus Holdings Inc                             | LANTHEUS HOLDING                            | CUSIP: 516544103<br>LEI: 5299005HUB5IOJGO7S39 | Long             | EC               | CORP              | US        |    237396 | NS      | $14737543.68   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Amphastar Pharmaceuticals Inc                     | AMPHASTAR PHARMA                            | CUSIP: 03209R103<br>LEI: 54930055TH0ZLSAQMJ38 | Long             | EC               | CORP              | US        |    134191 | NS      | $3957292.59    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Globus Medical Inc                                | GLOBUS MEDICAL I                            | CUSIP: 379577208<br>LEI: 5299003M2P4CIK0RF205 | Long             | EC               | CORP              | US        |    274027 | NS      | $20247855.03   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Fate Therapeutics Inc                             | FATE THERAPEUTIC                            | CUSIP: 31189P102<br>LEI: 549300L14Q4UHOODLA90 | Long             | EC               | CORP              | US        |    271188 | NS      | $5646134.16    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Teladoc Health Inc                                | TELADOC HEALTH I                            | CUSIP: 87918A105<br>LEI: 549300I2PVFBC9MFAC61 | Long             | EC               | CORP              | US        |    556664 | NS      | $15870490.64   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Replimune Group Inc                               | REPLIMUNE GROUP                             | CUSIP: 76029N106<br>LEI: 549300AY704NEIRC4K64 | Long             | EC               | CORP              | US        |     88671 | NS      | $1815095.37    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Veracyte Inc                                      | VERACYTE INC                                | CUSIP: 92337F107<br>LEI: 529900ESWZRHXOW27Z37 | Long             | EC               | CORP              | US        |    246705 | NS      | $6843596.70    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Stoke Therapeutics Inc                            | STOKE THERAPEUTI                            | CUSIP: 86150R107<br>LEI: 549300RD25SS2DIJHJ67 | Long             | EC               | CORP              | US        |     54149 | NS      | $408283.46     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Seagen Inc                                        | SEAGEN INC                                  | CUSIP: 81181C104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    477885 | NS      | $58010460.15   | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Henry Schein Inc                                  | HENRY SCHEIN INC                            | CUSIP: 806407102<br>LEI: VGO3WGL8H45T73F4RR92 | Long             | EC               | CORP              | US        |    477532 | NS      | $38641889.44   | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Avanos Medical Inc                                | AVANOS MEDICAL I                            | CUSIP: 05350V106<br>LEI: 549300YCXWOM7NEWMQ58 | Long             | EC               | CORP              | US        |    165021 | NS      | $4439064.90    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| LHC Group Inc                                     | LHC GROUP INC                               | CUSIP: 50187A107<br>LEI: 5299009NPLWAMRQYZX73 | Long             | EC               | CORP              | US        |    101845 | NS      | $16642491.45   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Crinetics Pharmaceuticals Inc                     | CRINETICS PHARMA                            | CUSIP: 22663K107<br>LEI: 549300Q1CNFXK5P31D28 | Long             | EC               | CORP              | US        |    130533 | NS      | $2332624.71    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Silk Road Medical Inc                             | SILK ROAD MEDICA                            | CUSIP: 82710M100<br>LEI: 549300VL8KC0ZPDQHE14 | Long             | EC               | CORP              | US        |    122408 | NS      | $6518226.00    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Incyte Corp                                       | INCYTE CORP                                 | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |    651382 | NS      | $51895603.94   | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Laboratory Corp of America Holdings               | LABORATORY CP                               | CUSIP: 50540R409<br>LEI: OZ7UA8IXAIFILY2VZH07 | Long             | EC               | CORP              | US        |    320839 | NS      | $77225947.30   | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| CryoPort Inc                                      | CRYOPORT                                    | CUSIP: 229050307<br>LEI: 9845004D8538BT8JF626 | Long             | EC               | CORP              | US        |    170149 | NS      | $3360442.75    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Ionis Pharmaceuticals Inc                         | IONIS PHARMACEUT                            | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |    442390 | NS      | $18045088.10   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Krystal Biotech Inc                               | KRYSTAL BIOTECH                             | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |     61784 | NS      | $4803088.16    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Organogenesis Holdings Inc                        | ORGANOGENESIS HO                            | CUSIP: 68621F102<br>LEI: 549300RLC2O821TU6941 | Long             | EC               | CORP              | US        |    198501 | NS      | $543892.74     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Inovio Pharmaceuticals Inc                        | INOVIO PHARMACEU                            | CUSIP: 45773H201<br>LEI: 529900B9W875XDZXTM97 | Long             | EC               | CORP              | US        |    814820 | NS      | $1662232.80    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvation Bio Inc                                  | NUVATION BIO INC                            | CUSIP: 67080N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    409253 | NS      | $781673.23     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Meridian Bioscience Inc                           | MERIDIAN BIOSCI                             | CUSIP: 589584101<br>LEI: 549300ELSRZEFFFRX195 | Long             | EC               | CORP              | US        |    150765 | NS      | $4824480.00    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Rigel Pharmaceuticals Inc                         | RIGEL PHARMACEUT                            | CUSIP: 766559603<br>LEI: 529900KPTNUS5J8K9K66 | Long             | EC               | CORP              | US        |    585472 | NS      | $393203.00     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences Inc                        | NEUROCRINE BIOSC                            | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |    330974 | NS      | $42053556.44   | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Jazz Pharmaceuticals PLC                          | JAZZ PHARMACEUTI                            | CUSIP: G50871105<br>LEI: 635400GAUMJCLEZRRV50 | Long             | EC               | CORP              | US        |    215613 | NS      | $33831835.83   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| OptimizeRx Corp                                   | OPTIMIZERX CORP                             | CUSIP: 68401U204<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     55154 | NS      | $1163197.86    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Vanguard Cmt Funds-Vanguard Market Liquidity Fund | Vanguard Market Liquidity Fund              | CUSIP: N/A<br>LEI: 1I6HV0TLSTR3A4XQ6L78       | Long             | STIV             | CORP              | US        |         4 | NS      | $3.81          | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Boston Scientific Corp                            | BOSTON SCIENTIFC                            | CUSIP: 101137107<br>LEI: Y6ZDD9FP4P8JSSJMW954 | Long             | EC               | CORP              | US        |   4946190 | NS      | $223914021.30  | 1.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Cerevel Therapeutics Holdings Inc                 | CEREVEL THERAPEU                            | CUSIP: 15678U128<br>LEI: 254900RJNIRS9COSQR41 | Long             | EC               | CORP              | US        |    205726 | NS      | $5957824.96    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Eli Lilly & Co                                    | ELI LILLY & CO                              | CUSIP: 532457108<br>LEI: FRDRIPF3EKNDJ2CQJL29 | Long             | EC               | CORP              | US        |   2794615 | NS      | $1037025734.20 | 5.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Elanco Animal Health Inc                          | ELANCO ANIMAL HE                            | CUSIP: 28414H103<br>LEI: 549300SHPNDCE059M934 | Long             | EC               | CORP              | US        |   1475698 | NS      | $18992233.26   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| CRISPR Therapeutics AG                            | CRISPR THERAPEUT                            | CUSIP: H17182108<br>LEI: 506700O6IRRIQLT3W370 | Long             | EC               | CORP              | US        |    255152 | NS      | $13979778.08   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| 1Life Healthcare Inc                              | 1LIFE HEALTHCARE                            | CUSIP: 68269G107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    470138 | NS      | $7987644.62    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| MaxCyte Inc                                       | MAXCYTE INC                                 | CUSIP: 57777K106<br>LEI: 54930053YHXULRFCU991 | Long             | EC               | CORP              | US        |    243517 | NS      | $1458666.83    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Heron Therapeutics Inc                            | HERON THERAPEUTI                            | CUSIP: 427746102<br>LEI: 549300DR2I1DOPD2IX53 | Long             | EC               | CORP              | US        |    405400 | NS      | $1098634.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Abbott Laboratories                               | ABBOTT LABS                                 | CUSIP: 002824100<br>LEI: HQD377W2YR662HK5JX27 | Long             | EC               | CORP              | US        |   6058400 | NS      | $651762672.00  | 3.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Owens & Minor Inc                                 | OWENS & MINOR                               | CUSIP: 690732102<br>LEI: 549300LMT5KQQXCEZ733 | Long             | EC               | CORP              | US        |    250615 | NS      | $5165175.15    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| QuidelOrtho Corp                                  | QUIDELORTHO CORP                            | CUSIP: 219798105<br>LEI: 549300YU8CMO9HF53113 | Long             | EC               | CORP              | US        |    173503 | NS      | $15200597.83   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Myriad Genetics Inc                               | MYRIAD GENETICS                             | CUSIP: 62855J104<br>LEI: 52990044IHUOUMETT163 | Long             | EC               | CORP              | US        |    279283 | NS      | $5658273.58    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| 23andMe Holding Co                                | 23ANDME HOLDIN-A                            | CUSIP: 90138Q108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    847094 | NS      | $2583636.70    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Addus HomeCare Corp                               | ADDUS HOMECARE                              | CUSIP: 006739106<br>LEI: 52990090ZT33AKPDBX62 | Long             | EC               | CORP              | US        |     55407 | NS      | $6110283.96    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Figs Inc                                          | FIGS INC-CLASS A                            | CUSIP: 30260D103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    245424 | NS      | $1921669.92    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Verve Therapeutics Inc                            | VERVE THERAPEUTI                            | CUSIP: 92539P101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    111621 | NS      | $2592955.83    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| CareDx Inc                                        | CAREDX INC                                  | CUSIP: 14167L103<br>LEI: 549300NQOFKL9NON0U06 | Long             | EC               | CORP              | US        |    184176 | NS      | $2385079.20    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcus Biosciences Inc                             | ARCUS BIOSCIENCE                            | CUSIP: 03969F109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    148139 | NS      | $5210048.63    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Madrigal Pharmaceuticals Inc                      | MADRIGAL PHARMAC                            | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |     40997 | NS      | $2874299.67    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| CorVel Corp                                       | CORVEL CORP                                 | CUSIP: 221006109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     33183 | NS      | $5076003.51    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| uniQure NV                                        | UNIQURE NV                                  | CUSIP: N90064101<br>LEI: 724500RPCTZLFYJZ3S98 | Long             | EC               | CORP              | US        |    144890 | NS      | $3833789.40    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Imago Biosciences Inc                             | IMAGO BIOSCIENCE                            | CUSIP: 45250K107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     46128 | NS      | $1646308.32    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Fulcrum Therapeutics Inc                          | FULCRUM THERAPEU                            | CUSIP: 359616109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    129648 | NS      | $888088.80     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Collegium Pharmaceutical Inc                      | COLLEGIUM PHARMA                            | CUSIP: 19459J104<br>LEI: 54930049FXZMTLW8D496 | Long             | EC               | CORP              | US        |    112436 | NS      | $2458975.32    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Tandem Diabetes Care Inc                          | TANDEM DIABETES                             | CUSIP: 875372203<br>LEI: 549300JEPFOD0K4D3I05 | Long             | EC               | CORP              | US        |    220743 | NS      | $9282243.15    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Intuitive Surgical Inc                            | INTUITIVE SURGIC                            | CUSIP: 46120E602<br>LEI: 54930052SRG011710797 | Long             | EC               | CORP              | US        |   1242337 | NS      | $335915501.43  | 1.62%             |  |  |  | No            |                  1 | On Loan: No      |
| Dexcom Inc                                        | DEXCOM                                      | CUSIP: 252131107<br>LEI: 549300YSK3QDSFR5EU59 | Long             | EC               | CORP              | US        |   1358547 | NS      | $157971845.16  | 0.76%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytokinetics Inc                                  | CYTOKINETICS INC                            | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |    282769 | NS      | $12017682.50   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Zoetis Inc                                        | ZOETIS INC                                  | CUSIP: 98978V103<br>LEI: 549300HD9Q1LOC9KLJ48 | Long             | EC               | CORP              | US        |   1628751 | NS      | $251055679.14  | 1.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Iovance Biotherapeutics Inc                       | IOVANCE BIOTHERA                            | CUSIP: 462260100<br>LEI: 549300220Z2GHH33XL82 | Long             | EC               | CORP              | US        |    409172 | NS      | $2618700.80    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| PDL BioPharma Inc                                 | PDL BIOPHARMA IN                            | CUSIP: 69329Y104<br>LEI: FE4K0NQFI4D86DSOL165 | Long             | EC               | CORP              | US        |    311327 | NS      | $392272.02     | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Pulmonx Corp                                      | PULMONX CORP                                | CUSIP: 745848101<br>LEI: 549300WZMFR0ZK7RJY40 | Long             | EC               | CORP              | US        |     97520 | NS      | $587070.40     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Prestige Consumer Healthcare Inc                  | PRESTIGE CONSUME                            | CUSIP: 74112D101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    173723 | NS      | $10677015.58   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Prometheus Biosciences Inc                        | PROMETHEUS BIOSC                            | CUSIP: 74349U108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     34218 | NS      | $1406701.98    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Agiliti Inc                                       | AGILITI INC                                 | CUSIP: 00848J104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    116123 | NS      | $1917190.73    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Alector Inc                                       | ALECTOR INC                                 | CUSIP: 014442107<br>LEI: 549300Z8RQOIY1JMHC25 | Long             | EC               | CORP              | US        |    187731 | NS      | $1593836.19    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Repare Therapeutics Inc                           | REPARE THERAPEUT                            | CUSIP: 760273102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     64323 | NS      | $1031097.69    | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Tenet Healthcare Corp                             | TENET HEALTHCARE                            | CUSIP: 88033G407<br>LEI: 0W9AIBT6U6ADJ2I8HK17 | Long             | EC               | CORP              | US        |    353984 | NS      | $16346981.12   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Agilent Technologies Inc                          | AGILENT TECH INC                            | CUSIP: 00846U101<br>LEI: QUIX8Y7A2WP0XRMW7G29 | Long             | EC               | CORP              | US        |   1034705 | NS      | $160358580.90  | 0.77%             |  |  |  | No            |                  1 | On Loan: No      |
| Pennant Group Inc/The                             | PENNANT GROUP-WI                            | CUSIP: 70805E109<br>LEI: 5493007H2OYR6BYLDA64 | Long             | EC               | CORP              | US        |     91848 | NS      | $949708.32     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Foghorn Therapeutics Inc                          | FOGHORN THERAPEU                            | CUSIP: 344174107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     71181 | NS      | $480471.75     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| TransMedics Group Inc                             | TRANSMEDICS GROU                            | CUSIP: 89377M109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    102959 | NS      | $6370073.33    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| West Pharmaceutical Services Inc                  | WEST PHARMACEUT                             | CUSIP: 955306105<br>LEI: 5493007NKRGM1RJQ1P16 | Long             | EC               | CORP              | US        |    256442 | NS      | $60176679.72   | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Alkermes PLC                                      | ALKERMES PLC                                | CUSIP: G01767105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    564034 | NS      | $13976762.52   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Gossamer Bio Inc                                  | GOSSAMER BIO INC                            | CUSIP: 38341P102<br>LEI: 549300ZOC0N2W6PSFR58 | Long             | EC               | CORP              | US        |    178825 | NS      | $1530742.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| McKesson Corp                                     | MCKESSON CORP                               | CUSIP: 58155Q103<br>LEI: 549300WZWOM80UCFSF54 | Long             | EC               | CORP              | US        |    502856 | NS      | $191930078.08  | 0.93%             |  |  |  | No            |                  1 | On Loan: No      |
| Edwards Lifesciences Corp                         | EDWARDS LIFE                                | CUSIP: 28176E108<br>LEI: YA13X31F3V31L8TMPR58 | Long             | EC               | CORP              | US        |   2151943 | NS      | $166237596.75  | 0.80%             |  |  |  | No            |                  1 | On Loan: No      |
| Apollo Medical Holdings Inc                       | APOLLO MEDICAL H                            | CUSIP: 03763A207<br>LEI: 5493008O4R82Q4STJ936 | Long             | EC               | CORP              | US        |    135358 | NS      | $3852288.68    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Vericel Corp                                      | VERICEL CORP                                | CUSIP: 92346J108<br>LEI: 54930076YM3PLTDR4B91 | Long             | EC               | CORP              | US        |    146057 | NS      | $3334481.31    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Treace Medical Concepts Inc                       | TREACE MEDICAL C                            | CUSIP: 89455T109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     57181 | NS      | $1323740.15    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Clover Health Investments Corp                    | CLOVER HEALTH IN                            | CUSIP: 18914F103<br>LEI: 5493000HLYOYQU6LK133 | Long             | EC               | CORP              | US        |   1101432 | NS      | $1442875.92    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Omniab Inc/old                                    | OMNIAB INC - 15                             | CUSIP: 68218J301<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     22076 | NS      | $0.22          | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Supernus Pharmaceuticals Inc                      | SUPERNUS PHARMAC                            | CUSIP: 868459108<br>LEI: 549300GRM36VBKISYJ58 | Long             | EC               | CORP              | US        |    183777 | NS      | $6748291.44    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| SI-BONE Inc                                       | SI-BONE INC                                 | CUSIP: 825704109<br>LEI: 549300J8JGYVJJHV9C31 | Long             | EC               | CORP              | US        |    100406 | NS      | $1232985.68    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Humacyte Inc                                      | HUMACYTE INC                                | CUSIP: 44486Q103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    193941 | NS      | $605095.92     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Advaxis Inc                                       | ADVAXIS INC-CW24                            | CUSIP: 007624125<br>LEI: 549300W71T0G7C14IM07 | Long             | EC               | CORP              | US        |      7710 | NS      | $0.08          | 0.00%             |  |  |  | No            |                  2 | On Loan: No      |
| Molina Healthcare Inc                             | MOLINA HEALTHCAR                            | CUSIP: 60855R100<br>LEI: 549300NQQCEQ46YHZ591 | Long             | EC               | CORP              | US        |    203119 | NS      | $68404385.63   | 0.33%             |  |  |  | No            |                  1 | On Loan: No      |
| Y-mAbs Therapeutics Inc                           | Y-MABS THERAPEUT                            | CUSIP: 984241109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    112294 | NS      | $501954.18     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| iRhythm Technologies Inc                          | IRHYTHM TECHNOLO                            | CUSIP: 450056106<br>LEI: 549300FJI72RJGDQS384 | Long             | EC               | CORP              | US        |    102861 | NS      | $11216992.05   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Kura Oncology Inc                                 | KURA ONCOLOGY IN                            | CUSIP: 50127T109<br>LEI: 5493005QORQTZCZYOP39 | Long             | EC               | CORP              | US        |    195176 | NS      | $3077925.52    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| CONMED Corp                                       | CONMED CORP                                 | CUSIP: 207410101<br>LEI: Z6C0YCECH9DCU5ZIQW84 | Long             | EC               | CORP              | US        |    102125 | NS      | $8461056.25    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals Inc                        | VERTEX PHARM                                | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |    885055 | NS      | $280031402.00  | 1.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Danaher Corp                                      | DANAHER CORP                                | CUSIP: 235851102<br>LEI: S4BKK9OTCEWQ3YHPFM11 | Long             | EC               | CORP              | US        |   2390055 | NS      | $653464937.55  | 3.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Nevro Corp                                        | NEVRO CORP                                  | CUSIP: 64157F103<br>LEI: 254900SH91I4BOYKUE38 | Long             | EC               | CORP              | US        |    115320 | NS      | $5386597.20    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Glaukos Corp                                      | GLAUKOS CORP                                | CUSIP: 377322102<br>LEI: 5299004JA1LHE21M6T14 | Long             | EC               | CORP              | US        |    163621 | NS      | $7619829.97    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Castle Biosciences Inc                            | CASTLE BIOSCIENC                            | CUSIP: 14843C105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     76882 | NS      | $1813646.38    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Cerus Corp                                        | CERUS CORP                                  | CUSIP: 157085101<br>LEI: 254900BIEY9XIDA04Q21 | Long             | EC               | CORP              | US        |    610140 | NS      | $2440560.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| ImmunityBio Inc                                   | IMMUNITYBIO INC                             | CUSIP: 45256X103<br>LEI: 529900J9XLBR4HFL4B83 | Long             | EC               | CORP              | US        |    409220 | NS      | $2254802.20    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Natera Inc                                        | NATERA INC                                  | CUSIP: 632307104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    356083 | NS      | $14642132.96   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| AMN Healthcare Services Inc                       | AMN HEALTHCARE                              | CUSIP: 001744101<br>LEI: 529900W3ARRTCNFH2I39 | Long             | EC               | CORP              | US        |    154599 | NS      | $19123896.30   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Shockwave Medical Inc                             | SHOCKWAVE MEDICA                            | CUSIP: 82489T104<br>LEI: 549300LDXO56IC5Y1538 | Long             | EC               | CORP              | US        |    123836 | NS      | $31404809.60   | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Quanterix Corp                                    | QUANTERIX CORP                              | CUSIP: 74766Q101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    119270 | NS      | $1586291.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Cogent Biosciences Inc                            | COGENT BIOSCIENC                            | CUSIP: 19240Q201<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    156556 | NS      | $1969474.48    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Royalty Pharma PLC                                | ROYALTY PHARMA-A                            | CUSIP: G7709Q104<br>LEI: 549300FGFN7VOK8BZR03 | Long             | EC               | CORP              | US        |   1203799 | NS      | $52931042.03   | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Integer Holdings Corp                             | INTEGER HOLDINGS                            | CUSIP: 45826H109<br>LEI: 549300SUD2ED5XG6X569 | Long             | EC               | CORP              | US        |    114048 | NS      | $8476047.36    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Exact Sciences Corp                               | EXACT SCIENCES                              | CUSIP: 30063P105<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |    608977 | NS      | $27373516.15   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Morphic Holding Inc                               | MORPHIC HOLDING                             | CUSIP: 61775R105<br>LEI: 549300RWWOUFLHTY1224 | Long             | EC               | CORP              | US        |     72573 | NS      | $1997208.96    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Brookdale Senior Living Inc                       | BROOKDALE SR                                | CUSIP: 112463104<br>LEI: LH7MQB13NWY7CJ9VC445 | Long             | EC               | CORP              | US        |    582590 | NS      | $1835158.50    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC Therapeutics Inc                              | PTC THERAPEUTICS                            | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |    222108 | NS      | $9215260.92    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| MacroGenics Inc                                   | MACROGENICS INC                             | CUSIP: 556099109<br>LEI: 5493001KJQUA83L8MH79 | Long             | EC               | CORP              | US        |    135840 | NS      | $873451.20     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Inari Medical Inc                                 | INARI MEDICAL IN                            | CUSIP: 45332Y109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    146995 | NS      | $10815892.10   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Atea Pharmaceuticals Inc                          | ATEA PHARMACEUTI                            | CUSIP: 04683R106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    255847 | NS      | $1199922.43    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| AtriCure Inc                                      | ATRICURE INC                                | CUSIP: 04963C209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    152785 | NS      | $6960884.60    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Acadia Healthcare Co Inc                          | ACADIA HEALTHCAR                            | CUSIP: 00404A109<br>LEI: 5493005CW985Y9D0NC11 | Long             | EC               | CORP              | US        |    313685 | NS      | $27936786.10   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Denali Therapeutics Inc                           | DENALI THERAPEUT                            | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |    297877 | NS      | $9505255.07    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Syneos Health Inc                                 | SYNEOS HEALTH IN                            | CUSIP: 87166B102<br>LEI: 549300F1ZGKDS8P6GU13 | Long             | EC               | CORP              | US        |    354713 | NS      | $12514274.64   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Apellis Pharmaceuticals Inc                       | APELLIS PHARMACE                            | CUSIP: 03753U106<br>LEI: 254900HS0ZFRXXSB9D42 | Long             | EC               | CORP              | US        |    295219 | NS      | $14740284.67   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Establishment Labs Holdings Inc                   | ESTABLISHMENT LA                            | CUSIP: G31249108<br>LEI: 549300BCBQ714JNJ7V58 | Long             | EC               | CORP              | US        |     66775 | NS      | $4257574.00    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Agios Pharmaceuticals Inc                         | AGIOS PHARMACEUT                            | CUSIP: 00847X104<br>LEI: 529900ONJHY8EOGYT555 | Long             | EC               | CORP              | US        |    170104 | NS      | $5126934.56    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| IDEXX Laboratories Inc                            | IDEXX LABS                                  | CUSIP: 45168D104<br>LEI: OGMTXK0LUU1HKV2P0J84 | Long             | EC               | CORP              | US        |    290677 | NS      | $123790613.99  | 0.60%             |  |  |  | No            |                  1 | On Loan: No      |
| Seres Therapeutics Inc                            | SERES THERAPEUTI                            | CUSIP: 81750R102<br>LEI: 549300GMXBE5NUWISF13 | Long             | EC               | CORP              | US        |    344690 | NS      | $2240485.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Vera Therapeutics Inc                             | VERA THERAPEUTIC                            | CUSIP: 92337R101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     51914 | NS      | $866963.80     | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| Privia Health Group Inc                           | PRIVIA HEALTH GR                            | CUSIP: 74276R102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    263569 | NS      | $6307206.17    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Becton Dickinson and Co                           | BECTON DICKINSON                            | CUSIP: 075887109<br>LEI: ICE2EP6D98PQUILVRZ91 | Long             | EC               | CORP              | US        |    986202 | NS      | $245899606.68  | 1.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals Inc                       | ALNYLAM PHARMACE                            | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |    393284 | NS      | $86754517.56   | 0.42%             |  |  |  | No            |                  1 | On Loan: No      |
| Paragon 28 Inc                                    | PARAGON 28 INC                              | CUSIP: 69913P105<br>LEI: 254900GM24PT1FMTRP66 | Long             | EC               | CORP              | US        |     91789 | NS      | $1881674.50    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Horizon Therapeutics Plc                          | HORIZON THERAPEU                            | CUSIP: G46188101<br>LEI: 529900P0GSQ79OOZEV53 | Long             | EC               | CORP              | US        |    755980 | NS      | $75817234.20   | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Intellia Therapeutics Inc                         | INTELLIA THERAPE                            | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |    236132 | NS      | $12151352.72   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Inhibrx Inc                                       | INHIBRX INC                                 | CUSIP: 45720L107<br>LEI: 549300VBKG2LTV1TLY22 | Long             | EC               | CORP              | US        |     80900 | NS      | $2425382.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Multiplan Corp                                    | MULTIPLAN CORP                              | CUSIP: 62548M100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    655458 | NS      | $976632.42     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| DocGo Inc                                         | DOCGO INC                                   | CUSIP: 256086109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    279358 | NS      | $2053281.30    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Vaxcyte Inc                                       | VAXCYTE INC                                 | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |    179798 | NS      | $8281495.88    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Novocure Ltd                                      | NOVOCURE LTD                                | CUSIP: G6674U108<br>LEI: 213800YPP55UMHWA4826 | Long             | EC               | CORP              | US        |    326045 | NS      | $25053297.80   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| CVS Health Corp                                   | CVS HEALTH CORP                             | CUSIP: 126650100<br>LEI: 549300EJG376EN5NQE29 | Long             | EC               | CORP              | US        |   4537203 | NS      | $462250241.64  | 2.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Cassava Sciences Inc                              | CASSAVA SCIENCES                            | CUSIP: 14817C107<br>LEI: 529900XA0UG5JXABYF08 | Long             | EC               | CORP              | US        |    131817 | NS      | $4591186.11    | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Corcept Therapeutics Inc                          | CORCEPT THERA                               | CUSIP: 218352102<br>LEI: 529900EO9LUTFMZ7FF90 | Long             | EC               | CORP              | US        |    330498 | NS      | $8354989.44    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Beam Therapeutics Inc                             | BEAM THERAPEUTIC                            | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    194776 | NS      | $8996703.44    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Universal Health Services Inc                     | UNIVERSAL HLTH-B                            | CUSIP: 913903100<br>LEI: 549300YGMGQDO0NMJD09 | Long             | EC               | CORP              | US        |    232572 | NS      | $30432046.20   | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Janux Therapeutics Inc                            | JANUX THERAPEUTI                            | CUSIP: 47103J105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     28442 | NS      | $387948.88     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Vaxart Inc                                        | VAXART INC                                  | CUSIP: 92243A200<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    429816 | NS      | $507182.88     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Mirati Therapeutics Inc                           | MIRATI THERAPEUT                            | CUSIP: 60468T105<br>LEI: 529900GYRW59IDQV6N54 | Long             | EC               | CORP              | US        |    134254 | NS      | $12268130.52   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Pacira BioSciences Inc                            | PACIRA BIOSCIENC                            | CUSIP: 695127100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    157122 | NS      | $7581136.50    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| HealthStream Inc                                  | HEALTHSTREAM INC                            | CUSIP: 42222N103<br>LEI: 529900OJ88H8635JNH64 | Long             | EC               | CORP              | US        |     82333 | NS      | $2091258.20    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Veeva Systems Inc                                 | VEEVA SYSTEMS-A                             | CUSIP: 922475108<br>LEI: 549300YZEXPDB92M2F02 | Long             | EC               | CORP              | US        |    484541 | NS      | $92237224.76   | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Xenon Pharmaceuticals Inc                         | XENON PHARMACEUT                            | CUSIP: 98420N105<br>LEI: 549300XV44Q9Z1MIPQ03 | Long             | EC               | CORP              | US        |    157625 | NS      | $5813210.00    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Centene Corp                                      | CENTENE CORP                                | CUSIP: 15135B101<br>LEI: 549300Z7JJ4TQSQGT333 | Long             | EC               | CORP              | US        |   2024025 | NS      | $176191376.25  | 0.85%             |  |  |  | No            |                  1 | On Loan: No      |
| American Well Corp                                | AMERICAN WELL -A                            | CUSIP: 03044L105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    681763 | NS      | $2488434.95    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| R1 RCM Inc                                        | R1 RCM INC                                  | CUSIP: 77634L105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    483870 | NS      | $4379023.50    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Guardant Health Inc                               | GUARDANT HEALTH                             | CUSIP: 40131M109<br>LEI: 254900M8C3E5VC8BR186 | Long             | EC               | CORP              | US        |    316999 | NS      | $16591727.66   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Viridian Therapeutics Inc                         | VIRIDIAN THERAPE                            | CUSIP: 92790C104<br>LEI: 549300C775BNYF550E70 | Long             | EC               | CORP              | US        |     97908 | NS      | $2474135.16    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Moderna Inc                                       | MODERNA INC                                 | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |   1170032 | NS      | $205820329.12  | 0.99%             |  |  |  | No            |                  1 | On Loan: No      |
| Cardinal Health Inc                               | CARDINAL HEALTH                             | CUSIP: 14149Y108<br>LEI: CCU46N3GJMF4OK4N7U60 | Long             | EC               | CORP              | US        |    942357 | NS      | $75548760.69   | 0.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Viatris Inc                                       | VIATRIS INC                                 | CUSIP: 92556V106<br>LEI: 254900ZZTSW7NL773X71 | Long             | EC               | CORP              | US        |   4197084 | NS      | $46293836.52   | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| STERIS PLC                                        | STERIS PLC                                  | CUSIP: G8473T100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    346227 | NS      | $64308202.98   | 0.31%             |  |  |  | No            |                  1 | On Loan: No      |
| Karuna Therapeutics Inc                           | KARUNA THERAPEUT                            | CUSIP: 48576A100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     92563 | NS      | $21780999.53   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Select Medical Holdings Corp                      | SELECT MEDICAL                              | CUSIP: 81619Q105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    384040 | NS      | $9439703.20    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Mettler-Toledo International Inc                  | METTLER-TOLEDO                              | CUSIP: 592688105<br>LEI: 5493000BD5GJNUDIUG10 | Long             | EC               | CORP              | US        |     78487 | NS      | $115341355.72  | 0.56%             |  |  |  | No            |                  1 | On Loan: No      |
| Oak Street Health Inc                             | OAK STREET HEALT                            | CUSIP: 67181A107<br>LEI: 2549007CJE6GSEURLA30 | Long             | EC               | CORP              | US        |    375440 | NS      | $8117012.80    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Bio-Techne Corp                                   | BIO-TECHNE CORP                             | CUSIP: 09073M104<br>LEI: 54930073RLKQ51TILZ35 | Long             | EC               | CORP              | US        |    543936 | NS      | $46229120.64   | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Definitive Healthcare Corp                        | DEFINITIVE HEALT                            | CUSIP: 24477E103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    116807 | NS      | $1328095.59    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Insmed Inc                                        | INSMED INC                                  | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |    460694 | NS      | $8518232.06    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Humana Inc                                        | HUMANA INC                                  | CUSIP: 444859102<br>LEI: 529900YLDW34GJAO4J06 | Long             | EC               | CORP              | US        |    437657 | NS      | $240667584.30  | 1.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Syndax Pharmaceuticals Inc                        | SYNDAX PHARMACEU                            | CUSIP: 87164F105<br>LEI: 529900OF94TRHKZVBS87 | Long             | EC               | CORP              | US        |    164416 | NS      | $3939407.36    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| ALX Oncology Holdings Inc                         | ALX ONCOLOGY HOL                            | CUSIP: 00166B105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     62053 | NS      | $688788.30     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| MannKind Corp                                     | MANNKIND CORP                               | CUSIP: 56400P706<br>LEI: 213800GFBCNY1ZFST722 | Long             | EC               | CORP              | US        |    828838 | NS      | $3878961.84    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Gilead Sciences Inc                               | GILEAD SCIENCES                             | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |   4140169 | NS      | $363631043.27  | 1.76%             |  |  |  | No            |                  1 | On Loan: No      |
| Travere Therapeutics Inc                          | TRAVERE THERAPEU                            | CUSIP: 89422G107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    185997 | NS      | $3744119.61    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| ICU Medical Inc                                   | ICU MEDICAL                                 | CUSIP: 44930G107<br>LEI: 5493003NRW7LS2QZRH60 | Long             | EC               | CORP              | US        |     70177 | NS      | $11174283.71   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Merus NV                                          | MERUS NV                                    | CUSIP: N5749R100<br>LEI: 549300W8GPUWU8QNU293 | Long             | EC               | CORP              | US        |     97421 | NS      | $1495412.35    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| UnitedHealth Group Inc                            | UNITEDHEALTH GRP                            | CUSIP: 91324P102<br>LEI: 549300GHBMY8T5GXDE41 | Long             | EC               | CORP              | US        |   3246184 | NS      | $1778129747.84 | 8.58%             |  |  |  | No            |                  1 | On Loan: No      |
| Novavax Inc                                       | NOVAVAX INC                                 | CUSIP: 670002401<br>LEI: 529900J4GJHPEPQ23205 | Long             | EC               | CORP              | US        |    271256 | NS      | $4473011.44    | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Invitae Corp                                      | INVITAE CORP                                | CUSIP: 46185L103<br>LEI: 549300MYI59DZW1WIX92 | Long             | EC               | CORP              | US        |    753436 | NS      | $2237704.92    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Ironwood Pharmaceuticals Inc                      | IRONWOOD PHARMAC                            | CUSIP: 46333X108<br>LEI: 549300PC8MR6QHH6P296 | Long             | EC               | CORP              | US        |    480968 | NS      | $5824522.48    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Cross Country Healthcare Inc                      | CROSS COUNTRY HE                            | CUSIP: 227483104<br>LEI: 54930037L0NBIPZ5S663 | Long             | EC               | CORP              | US        |    125769 | NS      | $4500014.82    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| iTeos Therapeutics Inc                            | ITEOS THERAPEUTI                            | CUSIP: 46565G104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     66515 | NS      | $1340277.25    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Repligen Corp                                     | REPLIGEN CORP                               | CUSIP: 759916109<br>LEI: 54930006QJ0T5AUO1E71 | Long             | EC               | CORP              | US        |    182286 | NS      | $32600028.24   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Aurinia Pharmaceuticals Inc                       | AURINIA PHARMACE                            | CUSIP: 05156V102<br>LEI: 5299008YP2BW4570ML28 | Long             | EC               | CORP              | US        |    414285 | NS      | $2125282.05    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| LeMaitre Vascular Inc                             | LEMAITRE VASCULA                            | CUSIP: 525558201<br>LEI: 549300FZUBUB7MHY8R17 | Long             | EC               | CORP              | US        |     68393 | NS      | $3204212.05    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Signify Health Inc                                | SIGNIFY HEALTH-A                            | CUSIP: 82671G100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    244308 | NS      | $6992094.96    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Neogen Corp                                       | NEOGEN CORP                                 | CUSIP: 640491106<br>LEI: 549300HJT9FC36N4UW43 | Long             | EC               | CORP              | US        |    747797 | NS      | $12383518.32   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Alphatec Holdings Inc                             | ALPHATEC HOLDING                            | CUSIP: 02081G201<br>LEI: 549300EZE8CQ8K65FS24 | Long             | EC               | CORP              | US        |    245494 | NS      | $2518768.44    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| AmerisourceBergen Corp                            | AMERISOURCEBERGE                            | CUSIP: 03073E105<br>LEI: AI8GXW8LG5WK7E9UD086 | Long             | EC               | CORP              | US        |    543569 | NS      | $92781792.61   | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Progenics Pharmaceuticals Inc                     | PROGENICS PHARMACEUTICALS CVR 2020          | CUSIP: N/A<br>LEI: 5299005B0KKBVJ0B2156       | Long             | EC               | CORP              | US        |    215826 | NS      | $2.16          | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Insulet Corp                                      | INSULET CORP                                | CUSIP: 45784P101<br>LEI: 549300TZTYD2PYN92D43 | Long             | EC               | CORP              | US        |    239861 | NS      | $71807187.57   | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Vir Biotechnology Inc                             | VIR BIOTECHNOLOG                            | CUSIP: 92764N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    252731 | NS      | $7132068.82    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Johnson & Johnson                                 | JOHNSON&JOHNSON                             | CUSIP: 478160104<br>LEI: 549300G0CFPGEF6X2043 | Long             | EC               | CORP              | US        |   9104404 | NS      | $1620583912.00 | 7.82%             |  |  |  | No            |                  1 | On Loan: No      |
| Merit Medical Systems Inc                         | MERIT MEDICAL                               | CUSIP: 589889104<br>LEI: 549300OYTY138SP2CE83 | Long             | EC               | CORP              | US        |    196583 | NS      | $14153976.00   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Joint Corp/The                                    | JOINT CORP/THE                              | CUSIP: 47973J102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     49946 | NS      | $744694.86     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Bio-Rad Laboratories Inc                          | BIO-RAD LABS-A                              | CUSIP: 090572207<br>LEI: 549300ZC1GPV35XYDK53 | Long             | EC               | CORP              | US        |     77602 | NS      | $32182325.42   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Atrion Corp                                       | ATRION CORP                                 | CUSIP: 049904105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4934 | NS      | $2984083.20    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Integra LifeSciences Holdings Corp                | INTEGRA LIFESCIE                            | CUSIP: 457985208<br>LEI: WB7IJCYY8YFTENS4O147 | Long             | EC               | CORP              | US        |    258465 | NS      | $14200067.10   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| OrthoPediatrics Corp                              | ORTHOPEDIATRICS                             | CUSIP: 68752L100<br>LEI: 5493000KUTPFGOPAT717 | Long             | EC               | CORP              | US        |     48732 | NS      | $2143720.68    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Schrodinger Inc/United States                     | SCHRODINGER INC                             | CUSIP: 80810D103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    202252 | NS      | $3640536.00    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Monte Rosa Therapeutics Inc                       | MONTE ROSA THERA                            | CUSIP: 61225M102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     63598 | NS      | $539311.04     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcturus Therapeutics Holdings Inc                | ARCTURUS THERAPE                            | CUSIP: 03969T109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     81226 | NS      | $1497807.44    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Amneal Pharmaceuticals Inc                        | AMNEAL PHARMACEU                            | CUSIP: 03168L105<br>LEI: 549300VV176ZO5WQHZ61 | Long             | EC               | CORP              | US        |    330868 | NS      | $847022.08     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| REGENXBIO Inc                                     | REGENXBIO INC                               | CUSIP: 75901B107<br>LEI: 549300EOES47LATSET33 | Long             | EC               | CORP              | US        |    126188 | NS      | $3015893.20    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Phathom Pharmaceuticals Inc                       | PHATHOM PHARMACE                            | CUSIP: 71722W107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     60066 | NS      | $599458.68     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| SpringWorks Therapeutics Inc                      | SPRINGWORKS THER                            | CUSIP: 85205L107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     94573 | NS      | $2286775.14    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Quantum-Si Inc                                    | QUANTUM-SI INC                              | CUSIP: 74765K105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    294020 | NS      | $699767.60     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Eagle Pharmaceuticals Inc/DE                      | EAGLE PHARMACEUT                            | CUSIP: 269796108<br>LEI: 549300TN20OLYTJVP152 | Long             | EC               | CORP              | US        |     41003 | NS      | $1489228.96    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Fulgent Genetics Inc                              | FULGENT GENETICS                            | CUSIP: 359664109<br>LEI: 549300CL6P01M68QJ404 | Long             | EC               | CORP              | US        |     68007 | NS      | $2466613.89    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Masimo Corp                                       | MASIMO CORP                                 | CUSIP: 574795100<br>LEI: 549300Q4A8JK0PIYCU29 | Long             | EC               | CORP              | US        |    182678 | NS      | $26477349.32   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| NextGen Healthcare Inc                            | NEXTGEN HEALTHCA                            | CUSIP: 65343C102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    196182 | NS      | $4080585.60    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Dynavax Technologies Corp                         | DYNAVAX TECHNOLO                            | CUSIP: 268158201<br>LEI: 549300T5URIXWDILX594 | Long             | EC               | CORP              | US        |    416506 | NS      | $5168839.46    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| REVOLUTION Medicines Inc                          | REVOLUTION MEDIC                            | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |    206645 | NS      | $4874755.55    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Tilray Brands Inc                                 | TILRAY BRANDS IN                            | CUSIP: 88688T100<br>LEI: 549300Y4V60733TO1478 | Long             | EC               | CORP              | US        |   1736730 | NS      | $6721145.10    | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Omnicell Inc                                      | OMNICELL INC                                | CUSIP: 68213N109<br>LEI: 5493008RH0GTKHHPZI77 | Long             | EC               | CORP              | US        |    152463 | NS      | $7868615.43    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2023-01-27

**Name of Applicant:** VANGUARD WORLD FUND

**Signature:** Ashley Grim

**Name of Signer:** Ashley Grim

**Title:** Treasurer