# EDGAR Filing Document

**Accession Number:** 0001034842
**File Stem:** 0001104659-25-074440
**Filing Date:** 2025-8
**Character Count:** 28202
**Document Hash:** fee387b9ae1b51c2022614f4fef003b8
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-25-074440.hdr.sgml**: 20250806

**ACCESSION NUMBER**: 0001104659-25-074440

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 15

**FILED AS OF DATE**: 20250806

**DATE AS OF CHANGE**: 20250806

**EFFECTIVENESS DATE**: 20250806

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** RIGEL PHARMACEUTICALS INC
- **CENTRAL INDEX KEY:** 0001034842
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 943248524
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-289281
- **FILM NUMBER:** 251187241

**BUSINESS ADDRESS:**
- **STREET 1:** 611 GATEWAY BOULEVARD, SUITE 900
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080
- **BUSINESS PHONE:** 650-624-1100

**MAIL ADDRESS:**
- **STREET 1:** 611 GATEWAY BOULEVARD, SUITE 900
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080

**As filed with the Securities and Exchange Commission on August 6, 2025**

**Registration No. 333-**

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**FORM S-8**

**REGISTRATION STATEMENT**

**UNDER**

**THE SECURITIES ACT OF 1933**

**RIGEL PHARMACEUTICALS, INC.**

(Exact name of registrant as specified in its charter)

---

| | |
|:---|:---|
| **Delaware** | **94-3248524** |
| (State or other jurisdiction of<br> incorporation or organization) | (I.R.S. Employer<br> Identification No.) |

---

**611 Gateway Boulevard, Suite 900**

**South San Francisco, California 94080**

(Address of principal executive offices, including zip code)

**Rigel Pharmaceuticals, Inc. Inducement Plan, as Amended**

**Rigel Pharmaceuticals, Inc. 2018 Equity Incentive Plan, as Amended**

(Full title of the plan)

**Raul R. Rodriguez**

**President and Chief Executive Officer**

**Rigel Pharmaceuticals, Inc.**

**611 Gateway Boulevard, Suite 900**

**South San Francisco, California 94080**

**(650) 624-1100**

(Name, address, including zip code, and telephone number, including area code, of agent for service)

**Copies to:**

**Carlton Fleming**

**Helen Theung**

**Sidley Austin LLP**

**555 California Street, Suite 2000**

**San Francisco, California 94104**

**(415) 772-1207**

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See definitions of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ◻ | Accelerated filer | ⌧ |
| Non-accelerated filer | ◻ | Smaller reporting company | ◻ |
|  |  | Emerging growth company | ◻ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.◻

**EXPLANATORY NOTE**

This Registration Statement on Form S-8 is being filed for the purpose of registering: (i) an additional 125,000 shares of common stock, par value $0.001 per share (the "Common Stock"), of Rigel Pharmaceuticals, Inc., a Delaware corporation (the "Company" or the "Registrant"), to be issued pursuant to the Rigel Pharmaceuticals, Inc. Inducement Plan, as amended (the "Inducement Plan"), which shares of Common Stock are in addition to the shares of Common Stock registered on the Registrant's Form S-8s filed with the Securities and Exchange Commission (the "Commission") on [August 6, 2024 (File No. 333-281306)](https://www.sec.gov/Archives/edgar/data/1034842/000110465924086334/tm2420634d3_s8.htm), [August 1, 2023 (File No. 333-273575)](https://www.sec.gov/Archives/edgar/data/1034842/000110465923086398/tm2322490d1_s8.htm), [March 7, 2023 (File No. 333-270329)](https://www.sec.gov/Archives/edgar/data/1034842/000110465923029576/tm238716d1_s8.htm), [August 3, 2022 (File No. 333-266501)](https://www.sec.gov/Archives/edgar/data/1034842/000110465922085710/tm2222340d1_s8.htm), [March 1, 2022 (File No. 333-263187)](https://www.sec.gov/Archives/edgar/data/1034842/000110465922028804/tm227975d1_s8.htm), [August 8, 2018 (File No. 333-226700)](https://www.sec.gov/Archives/edgar/data/1034842/000110465918050560/a18-18473_1s8.htm), [November 7, 2017 (File No. 333-221400)](https://www.sec.gov/Archives/edgar/data/1034842/000110465917066692/a17-26128_1s8.htm), [March 7, 2017 (File No. 333-216516)](https://www.sec.gov/Archives/edgar/data/1034842/000110465917014913/a17-7732_1s8.htm), and [November 1, 2016 (File No. 333-214370)](https://www.sec.gov/Archives/edgar/data/1034842/000110465916153781/a16-20844_1s8.htm) and (ii) an additional 700,000 shares of Common Stock to be issued pursuant to the Rigel Pharmaceuticals, Inc. 2018 Equity Incentive Plan, as amended (the "2018 Plan," and the Inducement Plan and the 2018 Plan, together, the "Plans"), which shares of Common Stock are in addition to the shares of Common Stock registered on the Registrant's Form S-8s filed with the Commission on [August 6, 2024 (File No. 333-281306)](https://www.sec.gov/Archives/edgar/data/1034842/000110465924086334/tm2420634d3_s8.htm), [August 1, 2023 (File No. 333-273575)](https://www.sec.gov/Archives/edgar/data/1034842/000110465923086398/tm2322490d1_s8.htm), [August 3, 2022 (File No. 333-266501)](https://www.sec.gov/Archives/edgar/data/1034842/000110465922085710/tm2222340d1_s8.htm), [June 21, 2021 (File No. 333-257226)](https://www.sec.gov/Archives/edgar/data/1034842/000110465921083460/tm2120174d1_s8.htm), [August 4, 2020 (File No. 333-240371)](https://www.sec.gov/Archives/edgar/data/1034842/000110465920090388/a20-26325_1s8.htm), [August 7, 2019 (File No. 333-233064)](https://www.sec.gov/Archives/edgar/data/1034842/000110465919044376/a19-16611_1s8.htm), and [August 8, 2018 (File No. 333-226700)](https://www.sec.gov/Archives/edgar/data/1034842/000110465918050560/a18-18473_1s8.htm). The Registrant's prior Form S-8s which are referenced in the preceding sentence are collectively referred to as the "Prior Form S-8s."

This Registration Statement on Form S-8 relates to securities of the same class as that to which the Prior Form S-8s relate, and is submitted in accordance with General Instruction E to Form S-8 regarding Registration of Additional Securities. Pursuant to General Instruction E of Form S-8, the contents of the Prior Form S-8s, to the extent relating to the registration of Common Stock issuable under the applicable Plan, are incorporated herein by reference and made part of this Registration Statement on Form S-8, except as amended hereby.

**PART II**

**INFORMATION REQUIRED IN THE REGISTRATION STATEMENT**

**Item 3. Incorporation of Documents by Reference.**

The following documents have been filed by the Registrant with the Commission and are incorporated herein by reference:

· [The Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2024, filed with the Commission on March 4, 2025 <u>;</u>](https://www.sec.gov/Archives/edgar/data/1034842/000155837025002169/rigl-20241231x10k.htm)

· The Registrant's Quarterly Reports on Form 10-Q for the quarterly periods ended [March 31, 2025](https://www.sec.gov/Archives/edgar/data/1034842/000155837025006493/rigl-20250331x10q.htm) and [June 30, 2025;](https://www.sec.gov/ix?doc=/Archives/edgar/data/1034842/000155837025010281/rigl-20250630x10q.htm)

· The Registrant's Current Reports on Form 8-K, filed with the Commission on [January 13, 2025](https://www.sec.gov/Archives/edgar/data/1034842/000110465925002874/tm253048d1_8k.htm) , [March 10, 2025](https://www.sec.gov/Archives/edgar/data/1034842/000110465925022224/tm258676d1_8k.htm) , [March 27, 2025](https://www.sec.gov/Archives/edgar/data/1034842/000110465925028564/tm2510607d1_8k.htm) and [May 23, 2025](https://www.sec.gov/Archives/edgar/data/1034842/000110465925052407/tm2516012d1_8k.htm) ; and

· [The description of the Common Stock contained in the Registrant's Registration Statement on Form 8-A, filed with the Commission on October 3, 2000, including any amendments or reports filed for the purpose of updating such description.](https://www.sec.gov/Archives/edgar/data/1034842/000091205700043550/a2026726z8-a12g.txt)

All documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), other than current reports furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits furnished on such form that relate to such items, prior to the filing of a post-effective amendment to this Registration Statement which indicates that all of the shares of Common Stock offered have been sold or which deregisters all of such shares then remaining unsold, shall be deemed to be incorporated by reference in this Registration Statement and to be a part hereof from the date of the filing of such documents.

For purposes of this Registration Statement, any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.

**Item 8. Exhibits.**

---

| | |
|:---|:---|
| **Exhibit<br> Number** |  |
| [4.1(1)](https://www.sec.gov/Archives/edgar/data/1034842/000110465903012978/j2357_ex3d1.htm) | [Amended and Restated Certificate of Incorporation of the Registrant.](https://www.sec.gov/Archives/edgar/data/1034842/000110465903012978/j2357_ex3d1.htm) |
| [4.2(2)](https://www.sec.gov/Archives/edgar/data/1034842/000110465912040165/a12-13153_1ex99d1.htm) | [Certificate of Amendment to Amended and Restated Certificate of Incorporation of the Registrant.](https://www.sec.gov/Archives/edgar/data/1034842/000110465912040165/a12-13153_1ex99d1.htm) |
| [4.3(3)](https://www.sec.gov/Archives/edgar/data/1034842/000110465918034498/a18-13825_1ex3d1.htm#Exhibit3_1_105938) | [Certificate of Amendment of Certificate of Incorporation of the Registrant.](https://www.sec.gov/Archives/edgar/data/1034842/000110465918034498/a18-13825_1ex3d1.htm#Exhibit3_1_105938) |
| [4.4(4)](https://www.sec.gov/Archives/edgar/data/1034842/000110465922114413/tm2229578d1_ex3-1.htm) | [Amended and Restated Bylaws of the Company.](https://www.sec.gov/Archives/edgar/data/1034842/000110465922114413/tm2229578d1_ex3-1.htm) |
| [4.5(5)](https://www.sec.gov/Archives/edgar/data/1034842/000110465924075697/tm2417992d2_ex3-1.htm) | [Certificate of Amendment to the Amended and Restated Certificate of Incorporation of the Registrant](https://www.sec.gov/Archives/edgar/data/1034842/000110465924075697/tm2417992d2_ex3-1.htm) |
| [4.6(6)](https://www.sec.gov/Archives/edgar/data/1034842/000110465903012978/j2357_ex4d1.htm) | [Specimen Common Stock Certificate of the Registrant.](https://www.sec.gov/Archives/edgar/data/1034842/000110465903012978/j2357_ex4d1.htm) |
| [5.1\*](tm2522417d1_ex5-1.htm) | [Opinion of Sidley Austin LLP.](tm2522417d1_ex5-1.htm) |
| [23.1\*](tm2522417d1_ex23-1.htm) | [Consent of Independent Registered Public Accounting Firm.](tm2522417d1_ex23-1.htm) |
| [23.2\*](tm2522417d1_ex5-1.htm) | [Consent of Sidley Austin LLP is contained in Exhibit 5.1 to this Registration Statement.](tm2522417d1_ex5-1.htm) |
| [24.1\*](#ABC1) | [Power of Attorney is contained on the signature pages to this Registration Statement.](#ABC1) |
| [99.1(7)](https://www.sec.gov/Archives/edgar/data/1034842/000155837025010281/rigl-20250630xex10d2.htm) | [Rigel Pharmaceuticals, Inc. Inducement Plan, as amended.](https://www.sec.gov/Archives/edgar/data/1034842/000155837025010281/rigl-20250630xex10d2.htm) |
| [99.2(7)](https://www.sec.gov/Archives/edgar/data/1034842/000155837025010281/rigl-20250630xex10d1.htm) | [Rigel Pharmaceuticals, Inc. 2018 Equity Incentive Plan, as amended.](https://www.sec.gov/Archives/edgar/data/1034842/000155837025010281/rigl-20250630xex10d1.htm) |
| [107\*](tm2522417d1_ex-filingfees.htm) | [Calculation of Filing Fee Table.](tm2522417d1_ex-filingfees.htm) |

---

(1) Document incorporated by reference to the Registrant's Current Report on Form 8-K (No. 000-29889), filed with the Commission on June 24, 2003.

(2) Document incorporated by reference to the Registrant's Current Report on Form 8-K (No. 000-29889), filed with the Commission on May 29, 2012.

(3) Document incorporated by reference to the Registrant's Current Report on Form 8-K (No. 000-29889), filed with the Commission on May 18, 2018.

(4) Document incorporated by reference to the Registrant's Current Report on Form 8-K (No. 000-29889), filed with the Commission on November 3, 2022.

(5) Document incorporated by reference to the Registrant's Current Report on Form 8-K (No. 000-29889), filed with the Commission on June 27, 2024.

(6) Document incorporated by reference to the Registrant's Current Report on Form 8-K (No. 000-29889), filed with the Commission on June 24, 2003.

(7) Document incorporated by reference to the Registrant's Quarterly Report on Form 10-Q (No. 000-29889), filed with the Commission on August 5, 2025.

\* Filed herewith.

**SIGNATURES**

Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of South San Francisco, State of California, on August 6, 2025.

---

| | |
|:---|:---|
| **RIGEL PHARMACEUTICALS, INC.** | **RIGEL PHARMACEUTICALS, INC.** |
| By: | /s/ Raul Rodriguez |
|  | Raul R. Rodriguez |
|  | *Chief Executive Officer* |

---

**POWER OF ATTORNEY**

**KNOW ALL PERSONS BY THESE PRESENTS,** that each person whose signature appears below constitutes and appoints Raul R. Rodriguez and Dean Schorno, and each or any one of them, his true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission (the "SEC"), and generally to do all such things in their names and behalf in their capacities as officers and directors to enable the registrant to comply with the provisions of the Securities Act and all requirements of the SEC, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or their or his substitutes or substitute, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

---

| | | |
|:---|:---|:---|
| **Signature** | **Title** | **Date** |
| /s/ Raul R. Rodriguez | President, Chief Executive Officer and Director | August 6, 2025 |
| Raul R. Rodriguez | *(Principal Executive Officer)* |  |
| /s/ Dean Schorno | Chief Financial Officer | August 6, 2025 |
| Dean Schorno | *(Principal Financial and Accounting Officer)* |  |
| /s/ Gregg A. Lapointe |  |  |
| Gregg A. Lapointe | Chairman of the Board of Directors | August 6, 2025 |
| /s/ Kamil Ali-Jackson |  |  |
| Kamil Ali-Jackson | Director | August 6, 2025 |
| /s/ Mark W. Frohlich |  |  |
| Mark W. Frohlich | Director | August 6, 2025 |
| /s/ Alison L. Hannah |  |  |
| Alison L. Hannah | Director | August 6, 2025 |
| /s/ Walter H. Moos |  |  |
| Walter H. Moos | Director | August 6, 2025 |
| /s/ Jane Wasman |  |  |
| Jane Wasman | Director | August 6, 2025 |

---

## Exhibit 5.1

**Exhibit 5.1**

---

| | |
|:---|:---|
|  | SIDLEY AUSTIN LLP |
| ![](tm2522417d1_ex5-1img01.jpg) | 555 CALIFORNIA STREET<br> SUITE 2000<br> SAN FRANCISCO, CA 94104 |
|  | +1 415 772 1200 |
|  | +1 415 772 7400 FAX |
|  | AMERICA • ASIA PACIFIC • EUROPE |

---

August 6, 2025

Rigel Pharmaceuticals, Inc.

611 Gateway Boulevard, Suite 900 <br> South San Francisco, California 94080

---

| | |
|:---|:---|
| Re: | <u>825,000 Shares of Common Stock, $0.001 par value per share</u> |

---

Ladies and Gentlemen:

We refer to the Registration Statement on Form S-8 (the "<u>Registration Statement</u>") being filed by Rigel Pharmaceuticals, Inc., a Delaware corporation (the "<u>Company</u>"), with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the "<u>Securities Act</u>"), relating to the registration of (i) 125,000 shares of common stock, par value $0.001 per share, of the Company (the "<u>Common Stock</u>"), which may be issued under the Rigel Pharmaceuticals, Inc. Inducement Plan, as amended (the "<u>Inducement Plan</u>") and (ii) 700,000 shares of Common Stock which may be issued under the Rigel Pharmaceuticals, Inc. 2018 Equity Incentive Plan, as amended (the "<u>2018 Plan</u>" and, together with the Inducement Plan, the "<u>Plans</u>," and the aggregate number of shares of Common Stock to be registered under the Registration Statement, the "<u>Registered Shares</u>").

This opinion letter is being delivered in accordance with the requirements of Item 601(b)(5) of Regulation S-K under the Securities Act.

We have examined the Registration Statement, the Company's amended and restated certificate of incorporation, as amended, the Plans, the resolutions adopted by the board of directors of the Company relating to the Registration Statement and the Plans and the proposal adopted by the stockholders of the Company relating to the 2018 Plan at the Company's 2025 Annual Meeting of Stockholders. We have also examined originals, or copies of originals certified to our satisfaction, of such agreements, documents, certificates and statements of the Company and other corporate documents and instruments, and have examined such questions of law, as we have considered relevant and necessary as a basis for this opinion letter. We have assumed the authenticity of all documents submitted to us as originals, the genuineness of all signatures, the legal capacity of all persons and the conformity with the original documents of any copies thereof submitted to us for examination. As to facts relevant to the opinions expressed herein, we have relied without independent investigation or verification upon, and assumed the accuracy and completeness of, certificates, letters and oral and written statements and representations of public officials and officers and other representatives of the Company.

Sidley Austin LLP is a limited liability partnership practicing in affiliation with other Sidley Austin partnerships.

![](tm2522417d1_ex5-1img01.jpg)

Rigel Pharmaceuticals, Inc.<br> August 6, 2025

Based on the foregoing, we are of the opinion that each Registered Share that is newly issued pursuant to each Plan will be validly issued, fully paid and non-assessable when: (i) the Registration Statement, as finally amended, shall have become effective under the Securities Act; (ii) such Registered Share shall have been duly issued and delivered in accordance with the applicable Plan; and (iii) a certificate representing such Registered Share shall have been duly executed, countersigned and registered and duly delivered to the person entitled thereto against payment of the agreed consideration therefor in an amount not less than the par value thereof or, if any such Registered Share is to be issued in uncertificated form, the Company's books shall reflect the issuance of such Registered Share to the person entitled thereto against payment of the agreed consideration therefor in an amount not less than the par value thereof, all in accordance with the applicable Plan.

This opinion letter is limited to the General Corporation Law of the State of Delaware. We express no opinion as to the laws, rules or regulations of any other jurisdiction, including, without limitation, the federal laws of the United States of America or any state securities or blue sky laws.

We hereby consent to the filing of this opinion letter as an exhibit to the Registration Statement and to all references to our Firm included in or made a part of the Registration Statement. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act.

---

| |
|:---|
| Very truly yours, |
| /s/ Sidley Austin LLP |
| Sidley Austin LLP |

---

## Exhibit 23.1

**Exhibit 23.1**

**Consent of Independent Registered Public Accounting Firm**

We consent to the incorporation by reference in the Registration Statement (Form S-8) pertaining to the Rigel Pharmaceuticals, Inc. Inducement Plan, as Amended and Rigel Pharmaceuticals, Inc. 2018 Equity Incentive Plan, as Amended of our reports dated March 4, 2025, with respect to the financial statements of Rigel Pharmaceuticals, Inc., and the effectiveness of internal control over financial reporting of Rigel Pharmaceuticals, Inc., included in its Annual Report (Form 10-K) for the year ended December 31, 2024, filed with the Securities and Exchange Commission.

/s/ Ernst & Young LLP

San Francisco, California

August 5, 2025

## Ex-Filing

?xml version='1.0' encoding='ASCII'? EX-FILING FEES

---

| |
|:---|
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Calculation of Filing Fee Tables**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **S-8**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **RIGEL PHARMACEUTICALS INC**  |

---

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Security Type**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Security Class Title**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Fee Calculation Rule**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Amount Registered**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Proposed Maximum Offering Price Per Unit**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Maximum Aggregate Offering Price**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Fee Rate**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Amount of Registration Fee**  |
| 1 | Equity | Common Stock, $0.001 par value per share | 457(a) | 125000 | $20.66 | $2582500.00 | 0.0001531 | $395.38 |
| 2 | Equity | Common Stock, $0.001 par value per share | 457(a) | 700000 | $20.66 | $14462000.00 | 0.0001531 | $2214.13 |
| Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: |  | $17044500.00  |  | $2609.51  |
| Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  |  |  |  | $0.00  |
| Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  |  |  |  | $2609.51  |

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Offering Note** <br>

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <sup>1</sup> (a) Represents shares of the Registrant's Common Stock that were added to the Rigel Pharmaceuticals, Inc. Inducement Plan, as amended (the "Inducement Plan"), pursuant to share reserve increases approved by the Registrant's Board of Directors. Pursuant to Rule 416(a) promulgated under the Securities Act of 1933, as amended, or the Securities Act, this Registration Statement shall also cover any additional shares of Registrant's Common Stock that become issuable under the Inducement Plan by reason of any stock dividend, stock split, recapitalization, or other similar transaction effected that results in an increase to the number of outstanding shares of Registrant's Common Stock, as applicable. (b) Filing fee is estimated in accordance with Rules 457(c) and 457(h) solely for the purpose of calculating the registration fee on the basis of $20.66 per share, the average of the high and low prices of the Registrant's Common Stock on July 30, 2025 as reported on the Nasdaq Global Select Market.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <sup>2</sup> (a) Represents shares of the Registrant's Common Stock that were added to the Rigel Pharmaceuticals, Inc. 2018 Equity Incentive Plan, as amended ("2018 Plan"), pursuant to a share reserve increase approved by the Registrant's Board of Directors and the Registrant's stockholders. Pursuant to Rule 416(a) promulgated under the Securities Act, this Registration Statement shall also cover any additional shares of Registrant's Common Stock that become issuable under the 2018 Plan by reason of any stock dividend, stock split, recapitalization, or other similar transaction effected that results in an increase to the number of outstanding shares of Registrant's Common Stock, as applicable. (b) Filing fee is estimated in accordance with Rules 457(c) and 457(h) solely for the purpose of calculating the registration fee on the basis of $20.66 per share, the average of the high and low prices of the Registrant's Common Stock on July 30, 2025 as reported on the Nasdaq Global Select Market.

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| | |
|:---|:---|
| | |
| **Rule 457(p)** | **Rule 457(p)** |
| Fee Offset Claims | N/A |
| Fee Offset Sources | N/A |

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