# EDGAR Filing Document

**Accession Number:** 0001840706
**File Stem:** 0000950103-25-010240
**Filing Date:** 2025-8
**Character Count:** 1983
**Document Hash:** 50e4182f9beb3ca49b42607ee2963eef
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000950103-25-010240.hdr.sgml**: 20250915

**ACCESSION NUMBER**: 0000950103-25-010240

**CONFORMED SUBMISSION TYPE**: CORRESP

**PUBLIC DOCUMENT COUNT**: 2

**FILED AS OF DATE**: 20250813

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** SOPHiA GENETICS SA
- **CENTRAL INDEX KEY:** 0001840706
- **STANDARD INDUSTRIAL CLASSIFICATION:** SERVICES-COMPUTER PROCESSING & DATA PREPARATION [7374]
- **ORGANIZATION NAME:** 06 Technology
- **EIN:** 000000000
- **STATE OF INCORPORATION:** V8
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** CORRESP

**BUSINESS ADDRESS:**
- **STREET 1:** LA PIECE, CH-1180
- **CITY:** ROLLE
- **STATE:** V8
- **ZIP:** 00000
- **BUSINESS PHONE:** 41 21 694 10 60

**MAIL ADDRESS:**
- **STREET 1:** LA PIECE, CH-1180
- **CITY:** ROLLE
- **STATE:** V8
- **ZIP:** 00000

![](image_001.jpg)

August 13, 2025<br><u>VIA EDGAR</u><br>

Securities and Exchange Commission<br> Division of Corporation Finance<br> 100 F Street, N.E.<br> Washington, D.C. 20549

Re: SOPHiA GENETICS SA<br> Registration Statement on Form F-3<br> Registration No. 333-289266

Ladies and Gentlemen:

In accordance with Rule 461 under the Securities Act of 1933, as amended, we hereby request acceleration of the effective date of the Registration Statement on Form F-3 (File No. 333-289266) (as amended, the "Registration Statement") of SOPHiA GENETICS SA. We respectfully request that the Registration Statement be declared effective as of 4:00 p.m., Eastern time, on August 15, 2025 or as soon as practicable thereafter.

Once the Registration Statement has been declared effective, please orally confirm that event with our counsel, Davis Polk & Wardwell LLP, by calling Sierra Acosta at (212) 450-3504.

Thank you for your assistance in this matter.

Sincerely,

---

| | |
|:---|:---|
| SOPHiA GENETICS SA | SOPHiA GENETICS SA |
| By: | /s/ Daan van Well |
|  | Name: Daan van Well |
|  | Title: Chief Legal & Regulatory Officer |

---