# EDGAR Filing Document

**Accession Number:** 0001595725
**File Stem:** 0001172661-26-002225
**Filing Date:** 2026-5
**Character Count:** 14023
**Document Hash:** b7643c0e19be41acd048199a5f6681ba
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001172661-26-002225.hdr.sgml**: 20260515

**ACCESSION NUMBER**: 0001172661-26-002225

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20260331

**FILED AS OF DATE**: 20260515

**DATE AS OF CHANGE**: 20260515

**EFFECTIVENESS DATE**: 20260515

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Rock Springs Capital Management LP
- **CENTRAL INDEX KEY:** 0001595725

**ORGANIZATION NAME:**
- **EIN:** 800944416
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-16048
- **FILM NUMBER:** 26985320

**BUSINESS ADDRESS:**
- **STREET 1:** 650 SOUTH EXETER STREET
- **STREET 2:** SUITE 1070
- **CITY:** BALTIMORE
- **STATE:** MD
- **ZIP:** 21202
- **BUSINESS PHONE:** 4102200129

**MAIL ADDRESS:**
- **STREET 1:** 650 SOUTH EXETER STREET
- **STREET 2:** SUITE 1070
- **CITY:** BALTIMORE
- **STATE:** MD
- **ZIP:** 21202

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 03-31-2026

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** Rock Springs Capital Management LP<br>**Address:** 650 South Exeter Street<br>Suite 1070<br>Baltimore, MD 21202

**Form 13F File Number:** 028-16048

**CRD Number (if applicable):** 000168648

**SEC File Number (if applicable):** 801-78511

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Nnamdi Etoh<br>**Title:** Chief Financial Officer<br>**Phone:** 410-220-0129

**Signature, Place, and Date of Signing:**

/s/  Nnamdi Etoh  Baltimore, MD  05-15-2026<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 100

**Form 13F Information Table Value Total:** $1696654121

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| ACADIA HEALTHCARE COMPANY IN | COM | 00404A109 |  | 1765945 | 75500 | SH |  | SOLE |  | 75500 | 0 | 0 |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 |  | 16772438 | 4472650 | SH |  | SOLE |  | 4472650 | 0 | 0 |
| AGILON HEALTH INC | COM NEW | 00857U206 |  | 2056600 | 260000 | SH |  | SOLE |  | 260000 | 0 | 0 |
| AGIOS PHARMACEUTICALS INC | COM | 00847X104 |  | 27035684 | 799163 | SH |  | SOLE |  | 799163 | 0 | 0 |
| ALKERMES PLC | SHS | G01767105 |  | 6505745 | 183986 | SH |  | SOLE |  | 183986 | 0 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 |  | 24484380 | 74000 | SH |  | SOLE |  | 74000 | 0 | 0 |
| ALPHATEC HLDGS INC | COM NEW | 02081G201 |  | 3808000 | 350000 | SH |  | SOLE |  | 350000 | 0 | 0 |
| AMICUS THERAPEUTIC | COM | 03152W109 |  | 304557 | 21062 | SH |  | SOLE |  | 21062 | 0 | 0 |
| AMYLYX PHARMACEUTICALS INC | COM | 03237H101 |  | 6946720 | 499764 | SH |  | SOLE |  | 499764 | 0 | 0 |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 |  | 6547433 | 162750 | SH |  | SOLE |  | 162750 | 0 | 0 |
| ARCELLX INC | COMMON STOCK | 03940C100 |  | 19503210 | 169859 | SH |  | SOLE |  | 169859 | 0 | 0 |
| ARCUS BIOSCIENCES INC | COM | 03969F109 |  | 3888000 | 180000 | SH |  | SOLE |  | 180000 | 0 | 0 |
| ARDELYX INC | COM | 039697107 |  | 13773843 | 2299473 | SH |  | SOLE |  | 2299473 | 0 | 0 |
| ARGENX SE | SPONSORED ADR | 04016X101 |  | 71929625 | 98500 | SH |  | SOLE |  | 98500 | 0 | 0 |
| ASCENDIS PHARMA A/S | SPONSORED ADR | 04351P101 |  | 44373620 | 194000 | SH |  | SOLE |  | 194000 | 0 | 0 |
| AZENTA INC | COM | 114340102 |  | 12025083 | 569100 | SH |  | SOLE |  | 569100 | 0 | 0 |
| BICARA THERAPEUTICS INC | COM | 055477103 |  | 9728100 | 489095 | SH |  | SOLE |  | 489095 | 0 | 0 |
| BIOCRYST PHARMACEUTICALS INC | COM | 09058V103 |  | 119952 | 12600 | SH |  | SOLE |  | 12600 | 0 | 0 |
| BOSTON SCIENTIFIC CORP | COM | 101137107 |  | 32335075 | 515300 | SH |  | SOLE |  | 515300 | 0 | 0 |
| BRIDGEBIO PHARMA INC | COM | 10806X102 |  | 9523845 | 128250 | SH |  | SOLE |  | 128250 | 0 | 0 |
| CARIS LIFE SCIENCES INC | COM | 142152107 |  | 10066440 | 563000 | SH |  | SOLE |  | 563000 | 0 | 0 |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 |  | 20626564 | 650270 | SH |  | SOLE |  | 650270 | 0 | 0 |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 |  | 13974608 | 351828 | SH |  | SOLE |  | 351828 | 0 | 0 |
| CENTURY THERAPEUTICS INC | COM | 15673T100 |  | 2947824 | 1304347 | SH |  | SOLE |  | 1304347 | 0 | 0 |
| COGENT BIOSCIENCES INC | COM | 19240Q201 |  | 24023726 | 624155 | SH |  | SOLE |  | 624155 | 0 | 0 |
| COMPASS THERAPEUTICS INC | COM | 20454B104 |  | 17485079 | 3305308 | SH |  | SOLE |  | 3305308 | 0 | 0 |
| CORCEPT THERAPEUTICS INC | COM | 218352102 |  | 2025578 | 50250 | SH |  | SOLE |  | 50250 | 0 | 0 |
| CVS HEALTH CORP | COM | 126650100 |  | 2872800 | 40000 | SH |  | SOLE |  | 40000 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 2989941 | 45364 | SH |  | SOLE |  | 45364 | 0 | 0 |
| DANAHER CORP DEL | COM | 235851102 |  | 11660400 | 61500 | SH |  | SOLE |  | 61500 | 0 | 0 |
| DEXCOM INC | COM | 252131107 |  | 22331680 | 355600 | SH |  | SOLE |  | 355600 | 0 | 0 |
| DIANTHUS THERAPEUTICS INC | COM | 252828108 |  | 2245447 | 26757 | SH |  | SOLE |  | 26757 | 0 | 0 |
| DYNE THERAPEUTICS INC | COM | 26818M108 |  | 17625950 | 972198 | SH |  | SOLE |  | 972198 | 0 | 0 |
| EDAP TMS S A | SPONSORED ADR | 268311107 |  | 5126160 | 1378000 | SH |  | SOLE |  | 1378000 | 0 | 0 |
| EDWARDS LIFESCIENCES CORP | COM | 28176E108 |  | 2314312 | 28900 | SH |  | SOLE |  | 28900 | 0 | 0 |
| ELI LILLY  CO | COM | 532457108 |  | 90781299 | 98700 | SH |  | SOLE |  | 98700 | 0 | 0 |
| ENLIVEN THERAPEUTICS INC | COM | 29337E102 |  | 32398800 | 826500 | SH |  | SOLE |  | 826500 | 0 | 0 |
| ERASCA INC | COM | 29479A108 |  | 17854128 | 1103469 | SH |  | SOLE |  | 1103469 | 0 | 0 |
| EVOLENT HEALTH INC | CL A | 30050B101 |  | 6099000 | 2675000 | SH |  | SOLE |  | 2675000 | 0 | 0 |
| EYEPOINT INC | COM NEW | 30233G209 |  | 3335146 | 258739 | SH |  | SOLE |  | 258739 | 0 | 0 |
| GOSSAMER BIO INC | COM | 38341P102 |  | 528718 | 1609492 | SH |  | SOLE |  | 1609492 | 0 | 0 |
| HEARTFLOW INC | COM | 42238D107 |  | 13928925 | 572500 | SH |  | SOLE |  | 572500 | 0 | 0 |
| IMMUNOME INC | COM | 45257U108 |  | 7603455 | 347666 | SH |  | SOLE |  | 347666 | 0 | 0 |
| INDIVIOR PHARMACEUTICALS INC | COM | 45579U109 |  | 6096000 | 200000 | SH |  | SOLE |  | 200000 | 0 | 0 |
| INSMED INC | COM PAR $.01 | 457669307 |  | 51394336 | 314300 | SH |  | SOLE |  | 314300 | 0 | 0 |
| INSPIRE MED SYS INC | COM | 457730109 |  | 6798244 | 131800 | SH |  | SOLE |  | 131800 | 0 | 0 |
| INTUITIVE SURGICAL INC | COM NEW | 46120E602 |  | 37801180 | 82000 | SH |  | SOLE |  | 82000 | 0 | 0 |
| IRHYTHM HOLDINGS INC | COM | 450056106 |  | 30891735 | 261750 | SH |  | SOLE |  | 261750 | 0 | 0 |
| JANUX THERAPEUTICS INC | COM | 47103J105 |  | 5101425 | 367009 | SH |  | SOLE |  | 367009 | 0 | 0 |
| JASPER THERAPEUTICS INC | COM NEW | 471871202 |  | 964456 | 1100726 | SH |  | SOLE |  | 1100726 | 0 | 0 |
| JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 |  | 1087038 | 5750 | SH |  | SOLE |  | 5750 | 0 | 0 |
| KYMERA THERAPEUTICS INC | COM | 501575104 |  | 41384386 | 496871 | SH |  | SOLE |  | 496871 | 0 | 0 |
| LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 |  | 732645 | 40500 | SH |  | SOLE |  | 40500 | 0 | 0 |
| LENZ THERAPEUTICS INC | COM | 52635N103 |  | 2355759 | 257460 | SH |  | SOLE |  | 257460 | 0 | 0 |
| MADRIGAL PHARMACEUTICALS INC | COM | 558868105 |  | 89512847 | 170999 | SH |  | SOLE |  | 170999 | 0 | 0 |
| MBX BIOSCIENCES INC | COM | 55287L101 |  | 8595815 | 287967 | SH |  | SOLE |  | 287967 | 0 | 0 |
| MINERALYS THERAPEUTICS INC | COM | 603170101 |  | 11912855 | 439751 | SH |  | SOLE |  | 439751 | 0 | 0 |
| MINIMED GROUP INC | COM | 60365F109 |  | 15740600 | 1055000 | SH |  | SOLE |  | 1055000 | 0 | 0 |
| MIRUM PHARMACEUTICALS INC | COM | 604749101 |  | 74947340 | 811294 | SH |  | SOLE |  | 811294 | 0 | 0 |
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 |  | 1150088 | 61700 | SH |  | SOLE |  | 61700 | 0 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 |  | 19820283 | 150450 | SH |  | SOLE |  | 150450 | 0 | 0 |
| NEUROGENE INC | COM | 64135M105 |  | 2103474 | 104339 | SH |  | SOLE |  | 104339 | 0 | 0 |
| NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | N62509109 |  | 18847296 | 588794 | SH |  | SOLE |  | 588794 | 0 | 0 |
| NOVO-NORDISK A S | ADR | 670100205 |  | 3307500 | 90000 | SH |  | SOLE |  | 90000 | 0 | 0 |
| OCULAR THERAPEUTIX INC | COM | 67576A100 |  | 3250075 | 383716 | SH |  | SOLE |  | 383716 | 0 | 0 |
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 |  | 2540336 | 170378 | SH |  | SOLE |  | 170378 | 0 | 0 |
| OMADA HEALTH INC | COM | 68170A108 |  | 6800370 | 541000 | SH |  | SOLE |  | 541000 | 0 | 0 |
| ORUKA THERAPEUTICS INC | COM | 687604108 |  | 202233 | 4123 | SH |  | SOLE |  | 4123 | 0 | 0 |
| PENUMBRA INC | COM | 70975L107 |  | 39568585 | 120500 | SH |  | SOLE |  | 120500 | 0 | 0 |
| PHARVARIS N V | COM | N69605108 |  | 18236307 | 645533 | SH |  | SOLE |  | 645533 | 0 | 0 |
| PHREESIA INC | COM | 71944F106 |  | 5031352 | 600400 | SH |  | SOLE |  | 600400 | 0 | 0 |
| PTC THERAPEUTICS INC | COM | 69366J200 |  | 11023298 | 161798 | SH |  | SOLE |  | 161798 | 0 | 0 |
| REGENERON PHARMACEUTICALS | COM | 75886F107 |  | 7803664 | 10100 | SH |  | SOLE |  | 10100 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 117620471 | 1209465 | SH |  | SOLE |  | 1209465 | 0 | 0 |
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 |  | 59987384 | 689748 | SH |  | SOLE |  | 689748 | 0 | 0 |
| ROIVANT SCIENCES LTD | SHS | G76279101 |  | 2686900 | 97000 | SH |  | SOLE |  | 97000 | 0 | 0 |
| SCHOLAR ROCK HLDG CORP | COM | 80706P103 |  | 36369355 | 739816 | SH |  | SOLE |  | 739816 | 0 | 0 |
| SIONNA THERAPEUTICS INC | COM | 829401108 |  | 3986109 | 99429 | SH |  | SOLE |  | 99429 | 0 | 0 |
| SOLENO THERAPEUTICS INC | COM | 834203309 |  | 8612830 | 257253 | SH |  | SOLE |  | 257253 | 0 | 0 |
| SPDR SERIES TRUST | STATE STREET SPD | 78464A870 |  | 3831900 | 30000 | SH |  | SOLE |  | 30000 | 0 | 0 |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 |  | 30858459 | 640217 | SH |  | SOLE |  | 640217 | 0 | 0 |
| STRYKER CORPORATION | COM | 863667101 |  | 4863132 | 14800 | SH |  | SOLE |  | 14800 | 0 | 0 |
| SUMMIT THERAPEUTICS INC | COM | 86627T108 |  | 13461600 | 710000 | SH |  | SOLE |  | 710000 | 0 | 0 |
| SURGERY PARTNERS INC | COM | 86881A100 |  | 2479360 | 208000 | SH |  | SOLE |  | 208000 | 0 | 0 |
| TALPHERA INC | COM NEW | 00444T209 |  | 2680763 | 3589186 | SH |  | SOLE |  | 3589186 | 0 | 0 |
| TANGO THERAPEUTICS INC | COM | 87583X109 |  | 8094262 | 386915 | SH |  | SOLE |  | 386915 | 0 | 0 |
| TARSUS PHARMACEUTICALS INC | COM | 87650L103 |  | 15796307 | 225179 | SH |  | SOLE |  | 225179 | 0 | 0 |
| TENET HEALTHCARE CORP | COM NEW | 88033G407 |  | 23588750 | 125000 | SH |  | SOLE |  | 125000 | 0 | 0 |
| TERNS PHARMACEUTICALS INC | COM | 880881107 |  | 5996795 | 113748 | SH |  | SOLE |  | 113748 | 0 | 0 |
| TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADS | 881624209 |  | 1370460 | 45500 | SH |  | SOLE |  | 45500 | 0 | 0 |
| THERMO FISHER SCIENTIFIC INC | COM | 883556102 |  | 4915300 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| TRAVERE THERAPEUTICS INC | COM | 89422G107 |  | 43910013 | 1477954 | SH |  | SOLE |  | 1477954 | 0 | 0 |
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 |  | 25533294 | 1218773 | SH |  | SOLE |  | 1218773 | 0 | 0 |
| UNITEDHEALTH GROUP INC | COM | 91324P102 |  | 14341270 | 53000 | SH |  | SOLE |  | 53000 | 0 | 0 |
| VAXCYTE INC | COM | 92243G108 |  | 3501128 | 60250 | SH |  | SOLE |  | 60250 | 0 | 0 |
| VERA THERAPEUTICS INC | CL A | 92337R101 |  | 20259225 | 503585 | SH |  | SOLE |  | 503585 | 0 | 0 |
| VIKING THERAPEUTICS INC | COM | 92686J106 |  | 3123840 | 96000 | SH |  | SOLE |  | 96000 | 0 | 0 |
| XENON PHARMACEUTICALS INC | COM | 98420N105 |  | 44369613 | 763020 | SH |  | SOLE |  | 763020 | 0 | 0 |
| ZAI LAB LTD | ADR | 98887Q104 |  | 15324639 | 814707 | SH |  | SOLE |  | 814707 | 0 | 0 |
| ZENAS BIOPHARMA INC | COM | 98937L105 |  | 9815605 | 502077 | SH |  | SOLE |  | 502077 | 0 | 0 |

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