# EDGAR Filing Document

**Accession Number:** 0001395064
**File Stem:** 0001395064-26-000166
**Filing Date:** 2026-6
**Character Count:** 186624
**Document Hash:** 0301812a8ec9cc336e0a21805e77c4e3
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001395064-26-000166.hdr.sgml**: 20260605

**ACCESSION NUMBER**: 0001395064-26-000166

**CONFORMED SUBMISSION TYPE**: 6-K

**PUBLIC DOCUMENT COUNT**: 7

**CONFORMED PERIOD OF REPORT**: 20260605

**FILED AS OF DATE**: 20260605

**DATE AS OF CHANGE**: 20260605

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** TAKEDA PHARMACEUTICAL CO LTD
- **CENTRAL INDEX KEY:** 0001395064
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000

**FILING VALUES:**
- **FORM TYPE:** 6-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-38757
- **FILM NUMBER:** 261066803

**BUSINESS ADDRESS:**
- **STREET 1:** 1-1, NIHONBASHI-HONCHO 2-CHOME, CHUO-KU
- **CITY:** TOKYO
- **STATE:** M0
- **ZIP:** 103-8668
- **BUSINESS PHONE:** 81332782111

**MAIL ADDRESS:**
- **STREET 1:** 1-1, NIHONBASHI-HONCHO 2-CHOME, CHUO-KU
- **CITY:** TOKYO
- **STATE:** M0
- **ZIP:** 103-8668

**FORM 6-K**

**U.S. SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**Report of Foreign Private Issuer**

**Pursuant to Rule 13a-16 or 15d-16 of**

**the Securities Exchange Act of 1934**

**Commission File Number: 001-38757**

**For the month of June 2026**

**TAKEDA PHARMACEUTICAL COMPANY LIMITED**

**(Translation of registrant's name into English)**

**1-1, Nihonbashi-Honcho 2-Chome**

**Chuo-ku, Tokyo 103-8668**

**Japan**

**(Address of principal executive offices)**

Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.

Form 20-F ☒&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Form 40-F ☐

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1): ☐

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7): ☐

------

Information furnished on this form:

**EXHIBIT**

---

| | |
|:---|:---|
| Exhibit<br>Number |  |
| 1. | <u>[(English Translation) Earnings Report (Kessan Tanshin) for the Fiscal Year Ended March 31, 2026](#iafd21f41d74b426fbc571815fc440a84_10)</u> |
| 99.1 | <u>[Financial Appendix](exhibit991.htm)</u> |
| 99.2 | <u>[Additional Provision for Legal Proceedings and Revision of the Earnings Report (Kessan Tanshin) for the Fiscal Year Ended March 31, 2026 (IFRS, Consolidated)](revision.htm)</u> |

---

------

**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

---

| | | |
|:---|:---|:---|
| | **TAKEDA PHARMACEUTICAL COMPANY LIMITED** | **TAKEDA PHARMACEUTICAL COMPANY LIMITED** |
| Date: June 5, 2026 | By: | /s/ Norimasa Takeda |
|  |  | Norimasa Takeda |
|  |  | Chief Accounting Officer and Corporate Controller |

---

------

**Earnings Report (*Kessan Tanshin*) for the Fiscal Year Ended March 31, 2026 (IFRS, Consolidated)**

May 13, 2026

---

| | | | |
|:---|:---|:---|:---|
| **Takeda Pharmaceutical Company Limited** | **Takeda Pharmaceutical Company Limited** | Stock exchange listings: | Tokyo, Nagoya, Sapporo, Fukuoka |
| TSE Code: | 4502 | URL: https://www.takeda.com |  |
| Representative: | Christophe Weber, President & CEO |  |  |
| Contact: | Christopher O'Reilly | Telephone: +81-3-3278-2111 | Email: takeda.ir.contact@takeda.com |
|  | Global Head of IR, Global Finance |  | Email: takeda.ir.contact@takeda.com |

---

Scheduled date of annual general meeting of shareholders: June 24, 2026

Scheduled date of securities report submission: June 17, 2026

Scheduled date of dividend payment commencement: June 25, 2026

Supplementary materials for the financial statements: Yes

Presentation to explain for the financial statements: Yes

(Million JPY, rounded to the nearest million)

**1.** **Consolidated Financial Results for the Fiscal Year Ended March 31, 2026 (April 1, 2025 to March 31, 2026)**

(1)Consolidated Operating Results

---

| | | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) |
| | Revenue | Revenue | Operating profit | Operating profit | Profit before tax | Profit before tax | Net profit<br>for the year | Net profit<br>for the year | Net profit attributable to<br>owners of the Company | Net profit attributable to<br>owners of the Company |
| | (Million JPY) | (%) | (Million JPY) | (%) | (Million JPY) | (%) | (Million JPY) | (%) | (Million JPY) | (%) |
| For the Fiscal Year Ended March 31, 2026 | 4505720 | (1.7) | <u>6217</u> | <u>(98.2)</u> | <u>(142355)</u> | <u>-</u> | <u>(152125)</u> | <u>-</u> | <u>(152390)</u> | <u>-</u> |
| For the Fiscal Year Ended March 31, 2025 | 4581551 | 7.5 | 342586 | 60.0 | 175084 | 231.7 | 108143 | (25.0) | 107928 | (25.1) |
|  | Total comprehensive<br>income for the year | Total comprehensive<br>income for the year | Basic earnings<br>per share | Basic earnings<br>per share | Diluted earnings<br>per share | Diluted earnings<br>per share | Return on equity attributable to owners of the Company | Return on equity attributable to owners of the Company | Ratio of profit before income taxes to total assets | Ratio of profit before income taxes to total assets |
|  | (Million JPY) | (%) | (JPY) | (JPY) | (JPY) | (JPY) | (%) | (%) | (%) | (%) |
| For the Fiscal Year Ended March 31, 2026 | <u>780275</u> | - | <u>(96.75)</u> | <u>(96.75)</u> | <u>(96.75)</u> | <u>(96.75)</u> | <u>(2.1)</u> | <u>(2.1)</u> | <u>(1.0)</u> | <u>(1.0)</u> |
| For the Fiscal Year Ended March 31, 2025 | (57698) | - | 68.36 | 68.36 | 67.23 | 67.23 | 1.5 | 1.5 | 1.2 | 1.2 |
|  | Ratio of operating profit to revenue | Ratio of operating profit to revenue | Core Revenue | Core Revenue | Core Operating Profit | Core Operating Profit | Core EPS | Core EPS |  |  |
|  | (%) | (%) | (Billion JPY) | (%) | (Billion JPY) | (%) | (JPY) | (JPY) |  |  |
| For the Fiscal Year Ended March 31, 2026 | <u>0.1</u> | <u>0.1</u> | 4505.7 | (1.6) | 1172.5 | 0.8 | 517 | 517 |  |  |
| For the Fiscal Year Ended March 31, 2025 | 7.5 | 7.5 | 4579.8 | 7.4 | 1162.6 | 10.2 | 491 | 491 |  |  |

---

(Reference) Share of profit (loss) of investments accounted for using the equity method:

For the Fiscal Year Ended March 31, 2026 JPY -2,177 million For the Fiscal Year Ended March 31, 2025 JPY -3,986 million

(2)Consolidated Financial Position

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | Total assets<br>(Million JPY) | Total equity<br>(Million JPY) | Equity attributable<br>to owners of the<br>Company<br>(Million JPY) | Ratio of equity<br>attributable to<br>owners of the<br>Company to total<br>assets (%) | Equity attributable<br>to owners of the<br>Company per<br>share (JPY) |
| As of March 31, 2026 | <u>15511506</u> | <u>7430649</u> | <u>7429441</u> | <u>47.9</u> | <u>4702.66</u> |
| As of March 31, 2025 | 14248344 | 6935979 | 6935084 | 48.7 | 4407.01 |

---

------

(3)Consolidated Cash Flows

---

| | | | | |
|:---|:---|:---|:---|:---|
| | Net cash from <br>(used in) operating activities<br>(Million JPY) | Net cash from <br>(used in) investing activities<br>(Million JPY) | Net cash from <br>(used in) financing activities<br>(Million JPY) | Cash and cash equivalents at the end of the year (Million JPY) |
| For the Fiscal Year Ended March 31, 2026 | 1041431 | (369141) | (496820) | 595054 |
| For the Fiscal Year Ended March 31, 2025 | 1057182 | (367060) | (751425) | 385113 |

---

**2. Dividends**

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | Annual dividends per share (JPY) | Annual dividends per share (JPY) | Annual dividends per share (JPY) | Annual dividends per share (JPY) | Annual dividends per share (JPY) | Total Dividends (Million JPY) | Dividend Pay-out ratio (%) (Consolidated) | Ratio of dividends to net assets (%)<br>(Consolidated) |
| | 1st quarter end | 2nd quarter end | 3rd quarter end | Year-end | Total | Total Dividends (Million JPY) | Dividend Pay-out ratio (%) (Consolidated) | Ratio of dividends to net assets (%)<br>(Consolidated) |
| For the Fiscal Year Ended March 31, 2025 |  | 98.00 |  | 98.00 | 196.00 | 310656 | 286.7 | 4.3 |
| For the Fiscal Year Ended March 31, 2026 |  | 100.00 |  | 100.00 | 200.00 | 316964 | <u>—</u> | <u>4.4</u> |
| For the Fiscal Year Ending March 31, 2027 (Projection) |  | 102.00 |  | 102.00 | 204.00 |  |  |  |

---

**3.** **Forecasts for Consolidated Operating Results for the Fiscal Year Ending March 31, 2027 (April 1, 2026 to March 31, 2027)**

---

| | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) |
| | Revenue | Revenue | Operating profit | Operating profit | Profit before taxes | Profit before taxes | Net profit attributable to owners of the Company | Net profit attributable to owners of the Company | Basic earnings<br>per share |
| | (Million JPY) | (%) | (Million JPY) | (%) | (Million JPY) | (%) | (Million JPY) | (%) | (JPY) |
| For the Fiscal Year Ending March 31, 2027 | 4640000 | 3.0 | 420000 | <u>ー</u> | 252000 | <u>ー</u> | 166000 | <u>ー</u> | 104.26 |
| Forecasts for Core financial measures are shown below. | Forecasts for Core financial measures are shown below. | Forecasts for Core financial measures are shown below. | Forecasts for Core financial measures are shown below. | Forecasts for Core financial measures are shown below. | Forecasts for Core financial measures are shown below. | Forecasts for Core financial measures are shown below. | Forecasts for Core financial measures are shown below. | Forecasts for Core financial measures are shown below. | Forecasts for Core financial measures are shown below. |
|  | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) |
|  | Core Revenue | Core Revenue | Core Operating Profit | Core Operating Profit | Core EPS | Core EPS |  |  |  |
|  | (Million JPY) | (%) | (Million JPY) | (%) | (JPY) | (JPY) |  |  |  |
| For the Fiscal Year Ending March 31, 2027 | 4640000 | 3.0 | 1160000 | (1.1) | 472 | 472 |  |  |  |

---

The definition of Core financial measures is stated in "Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations" in the Financial Appendix.

**4.** **Management Guidance (Constant Exchange Rate basis) for the Fiscal Year Ending March 31, 2027**

Takeda uses change in Core Revenue, Core Operating Profit and Core EPS at Constant Exchange Rate (CER) basis as its Management Guidance.

---

| | | | |
|:---|:---|:---|:---|
| Change at CER | Core Revenue | Core Operating Profit | Core EPS |
|  | (%) | (%) | (%) |
| For the Fiscal Year Ending March 31, 2027 | Low-single digit % decline | 5% to 8% decline | Mid-teens % decline |

---

The definition of Constant Exchange Rate change is stated in "Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations" in the Financial Appendix.

------

**▪ Additional Information**

---

| | | | |
|:---|:---|:---|:---|
| (1) Significant changes in the scope of consolidation during the period | : | No | No |
| (2) Changes in accounting policies and changes in accounting estimates |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1) Changes in accounting policies required by IFRS | : | No | No |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2) Changes in accounting policies other than 1) | : | No | No |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3) Changes in accounting estimates | : | No | No |
| (3) Number of shares outstanding (common stock) |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1) Number of shares outstanding (including treasury stock) at year end: |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;March 31, 2026 |  | 1591229109 | shares |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;March 31, 2025 |  | 1590949609 | shares |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2) Number of shares of treasury stock at year end: |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;March 31, 2026 |  | 11392279 | shares |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;March 31, 2025 |  | 17299963 | shares |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3) Average number of outstanding shares (for the fiscal year ended March 31): | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3) Average number of outstanding shares (for the fiscal year ended March 31): | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3) Average number of outstanding shares (for the fiscal year ended March 31): | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3) Average number of outstanding shares (for the fiscal year ended March 31): |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;March 31, 2026 |  | 1575062414 | shares |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;March 31, 2025 |  | 1578872987 | shares |

---

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| **(Reference) Summary of Unconsolidated Results** | **(Reference) Summary of Unconsolidated Results** | **(Reference) Summary of Unconsolidated Results** | **(Reference) Summary of Unconsolidated Results** | **(Reference) Summary of Unconsolidated Results** | **(Reference) Summary of Unconsolidated Results** | **(Reference) Summary of Unconsolidated Results** |
| Summary of Unconsolidated Results for the Fiscal Year Ended March 31, 2026 (April 1, 2025 - March 31, 2026) | Summary of Unconsolidated Results for the Fiscal Year Ended March 31, 2026 (April 1, 2025 - March 31, 2026) | Summary of Unconsolidated Results for the Fiscal Year Ended March 31, 2026 (April 1, 2025 - March 31, 2026) | Summary of Unconsolidated Results for the Fiscal Year Ended March 31, 2026 (April 1, 2025 - March 31, 2026) | Summary of Unconsolidated Results for the Fiscal Year Ended March 31, 2026 (April 1, 2025 - March 31, 2026) | Summary of Unconsolidated Results for the Fiscal Year Ended March 31, 2026 (April 1, 2025 - March 31, 2026) | Summary of Unconsolidated Results for the Fiscal Year Ended March 31, 2026 (April 1, 2025 - March 31, 2026) |
| (1) Unconsolidated Operating Results | (1) Unconsolidated Operating Results | (1) Unconsolidated Operating Results | (1) Unconsolidated Operating Results | (1) Unconsolidated Operating Results | (1) Unconsolidated Operating Results | (1) Unconsolidated Operating Results |
| (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) | (Percentage figures represent changes over the previous fiscal year) |
|  | Net sales | Net sales | Operating income | Operating income | Ordinary income | Ordinary income |
|  | (Million JPY) | (%) | (Million JPY) | (%) | (Million JPY) | (%) |
| For the Fiscal Year Ended March 31, 2026 | 591604 | 1.9 | 21137 | (42.7) | 205504 | 137.3 |
| For the Fiscal Year Ended March 31, 2025 | 580360 | (2.6) | 36897 | (23.2) | 86594 | (69.8) |
|  | Net income | Net income | Earnings per share | Earnings per share | Fully diluted earnings per share | Fully diluted earnings per share |
|  | (Million JPY) | (%) | (JPY) | (JPY) | (JPY) | (JPY) |
| For the Fiscal Year Ended March 31, 2026 | 197335 | 29.1 | 125.29 | 125.29 | 125.26 | 125.26 |
| For the Fiscal Year Ended March 31, 2025 | 152820 | (54.9) | 96.79 | 96.79 | 96.78 | 96.78 |

---

---

| | | | | |
|:---|:---|:---|:---|:---|
| (2) Unconsolidated Financial Position | (2) Unconsolidated Financial Position | (2) Unconsolidated Financial Position | (2) Unconsolidated Financial Position | (2) Unconsolidated Financial Position |
|  | Total assets<br>(Million JPY) | Net assets<br>(Million JPY) | Shareholders' equity ratio (%) | Shareholders' equity per share (JPY) |
| As of March 31, 2026 | 9639677 | 3758926 | 39.0 | 2378.68 |
| As of March 31, 2025 | 9489375 | 3989355 | 42.0 | 2534.39 |

---

(Reference) Shareholders' equity As of March 31, 2026 &nbsp;&nbsp;&nbsp;&nbsp;JPY 3,757,932 million

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;As of March 31, 2025&nbsp;&nbsp;&nbsp;&nbsp;JPY 3,988,249 million

------

**▪ Earnings report (*Kessan Tanshin*) is exempt from audit conducted by certified public accountants or an audit firm**

**▪ Note to ensure appropriate use of forecasts and guidance, and other noteworthy items**

 • Takeda has adopted International Financial Reporting Standards (IFRS), and the disclosure information in this document is based on IFRS.

•  All forecasts and management guidance in this document are based on information and assumptions currently available to management, and do not represent a promise or guarantee to achieve these forecasts. Various uncertain factors could cause actual results to differ, such as changes in the business environment and fluctuations in foreign exchange rates. Should any significant event occur which requires the forecasts or guidance to be revised, Takeda will disclose it in a timely manner.

•  For details of the forecasts for consolidated operating results and the management guidance, please refer to "1. Financial Highlights for the Fiscal Year Ended March 31, 2026 <u>(5)</u> Outlook for the Fiscal Year Ending March 31, 2027" on <u>page [13](#iafd21f41d74b426fbc571815fc440a84_34)</u>.

 • Supplementary materials for the financial statements including the Quarterly Financial Report and Earnings Presentation of the conference call on May 13, 2026 and its audio will be promptly posted on Takeda's website.

(Takeda Website):

<u>https://www.takeda.com/investors/financial-results/</u>

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

**Attachment Index**

---

| | |
|:---|:---|
| **<u>[1. Financial Highlights for the Fiscal Year Ended March 31, 2026](#iafd21f41d74b426fbc571815fc440a84_16)</u>** | **<u>[2](#iafd21f41d74b426fbc571815fc440a84_16)</u>** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(1) Business Performance](#iafd21f41d74b426fbc571815fc440a84_19)</u> | <u>[2](#iafd21f41d74b426fbc571815fc440a84_19)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(2) Consolidated Financial Position](#iafd21f41d74b426fbc571815fc440a84_968)</u> | <u>[9](#iafd21f41d74b426fbc571815fc440a84_968)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(3) Consolidated Cash Flow](#iafd21f41d74b426fbc571815fc440a84_25)</u> | <u>[11](#iafd21f41d74b426fbc571815fc440a84_25)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(4) Other](#iafd21f41d74b426fbc571815fc440a84_1003)</u> | <u>[12](#iafd21f41d74b426fbc571815fc440a84_1003)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(](#iafd21f41d74b426fbc571815fc440a84_34)[5](#iafd21f41d74b426fbc571815fc440a84_34)[) Outlook for the Fiscal Year Ending March 31, 2027](#iafd21f41d74b426fbc571815fc440a84_34)</u> | <u>[13](#iafd21f41d74b426fbc571815fc440a84_34)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(](#iafd21f41d74b426fbc571815fc440a84_37)[6](#iafd21f41d74b426fbc571815fc440a84_37)[) Capital Allocation Policy and Dividends for the Fiscal Year Ended March 31, 2026 and Ending March 31, 2027](#iafd21f41d74b426fbc571815fc440a84_37)</u> | <u>[15](#iafd21f41d74b426fbc571815fc440a84_37)</u> |
| **<u>[2. Management Policy](#iafd21f41d74b426fbc571815fc440a84_40)</u>** | **<u>[16](#iafd21f41d74b426fbc571815fc440a84_40)</u>** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(1) Basic Management Policy](#iafd21f41d74b426fbc571815fc440a84_43)</u> | <u>[16](#iafd21f41d74b426fbc571815fc440a84_43)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(2) Business Environment, Mid- to Long-term Business Strategy and Issues to Be Addressed](#iafd21f41d74b426fbc571815fc440a84_46)</u> | <u>[16](#iafd21f41d74b426fbc571815fc440a84_46)</u> |
| **<u>[3. Basic Approach to the Section of Accounting Standards](#iafd21f41d74b426fbc571815fc440a84_49)</u>** | **<u>[18](#iafd21f41d74b426fbc571815fc440a84_49)</u>** |
| **<u>[4. Consolidated Financial Statements \[IFRS\] and Major Notes](#iafd21f41d74b426fbc571815fc440a84_52)</u>** | **<u>[19](#iafd21f41d74b426fbc571815fc440a84_55)</u>** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(1) Consolidated Statements of Profit or Loss](#iafd21f41d74b426fbc571815fc440a84_55)</u> | <u>[19](#iafd21f41d74b426fbc571815fc440a84_55)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(2) Consolidated Statements of Comprehensive Income](#iafd21f41d74b426fbc571815fc440a84_58)</u> | <u>[20](#iafd21f41d74b426fbc571815fc440a84_58)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(3) Consolidated Statements of Financial Position](#iafd21f41d74b426fbc571815fc440a84_61)</u> | <u>[21](#iafd21f41d74b426fbc571815fc440a84_61)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(4) Consolidated Statements of Changes in Equity](#iafd21f41d74b426fbc571815fc440a84_64)</u> | <u>[23](#iafd21f41d74b426fbc571815fc440a84_64)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(5) Consolidated Statements of Cash Flows](#iafd21f41d74b426fbc571815fc440a84_67)</u> | <u>[25](#iafd21f41d74b426fbc571815fc440a84_67)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(6) Notes to Consolidated Financial Statements](#iafd21f41d74b426fbc571815fc440a84_70)</u> | <u>[27](#iafd21f41d74b426fbc571815fc440a84_70)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(Going Concern Assumption)](#iafd21f41d74b426fbc571815fc440a84_73)</u> | <u>[27](#iafd21f41d74b426fbc571815fc440a84_73)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(Significant Items that Form the Basis of Preparing the Consolidated Financial Statements)](#iafd21f41d74b426fbc571815fc440a84_76)</u> | <u>[27](#iafd21f41d74b426fbc571815fc440a84_76)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(Operating Segment Information)](#iafd21f41d74b426fbc571815fc440a84_79)</u> | <u>[28](#iafd21f41d74b426fbc571815fc440a84_79)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(Earnings Per Share)](#iafd21f41d74b426fbc571815fc440a84_82)</u> | <u>[28](#iafd21f41d74b426fbc571815fc440a84_82)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(Significant Subsequent Events)](#iafd21f41d74b426fbc571815fc440a84_85)</u> | <u>[28](#iafd21f41d74b426fbc571815fc440a84_85)</u> |
| **[Financial Appendix]** |  |

---

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

**1. Financial Highlights for the Fiscal Year Ended March 31, 2026**

**(1) Business Performance**

**(i) Business Overview**

Takeda is a global R&D-driven biopharmaceutical company focused on discovering and delivering life-transforming treatments in our core therapeutic areas of gastrointestinal and inflammation, neuroscience and oncology, and through our plasma-derived therapies and vaccine business. Together with our partners, we advance the patient experience and expand treatment options for rare and more prevalent diseases through our robust, modality-diverse pipeline. Integration of advanced technologies and AI across our value chain is making our business operations more effective and efficient, increasing innovation and allowing us to better serve our stakeholders. We have a presence in approximately 80 countries and regions, a network of manufacturing sites around the world, and major research centers in Japan and the United States. Commercially, we have a very significant presence in the United States, Japan and Europe, as well as a growing business in China. Our employees around the world are united by our purpose and grounded in the values that have defined us for more than two centuries.

**(ii) Consolidated Financial Results (April 1, 2025 to March 31, 2026)**

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** |
| | **For the fiscal year ended**<br>**March 31,** | **For the fiscal year ended**<br>**March 31,** | AER | AER | CER |
| | **2025** | **2026** | JPY Change | % Change | % Change |
| Revenue | 4581.6 | 4505.7 | (75.8) | (1.7)% | (2.7)% |
| Cost of sales | (1580.2) | (1571.6) | 8.6 | (0.5)% | (1.9)% |
| Selling, general and administrative expenses | (1104.8) | (1084.2) | 20.6 | (1.9)% | (2.5)% |
| Research and development expenses | (730.2) | (675.9) | 54.3 | (7.4)% | (7.0)% |
| Amortization and impairment losses on intangible assets associated with products | (643.2) | (633.5) | 9.7 | (1.5)% | (1.7)% |
| Other operating income | 26.2 | 24.7 | (1.5) | (5.6)% | (4.4)% |
| Other operating expenses | (206.7) | <u>(559.0)</u> | <u>(352.2)</u> | <u>170.4</u> <u>%</u> | <u>168.9</u> <u>%</u> |
| Operating profit | 342.6 | <u>6.2</u> | <u>(336.4)</u> | <u>(98.2)</u><u>%</u> | <u>―</u> |
| Finance income and (expenses), net | (163.5) | (146.4) | 17.1 | (10.5)% | (7.5)% |
| Share of loss of investments accounted for using the equity method | (4.0) | (2.2) | 1.8 | (45.4)% | (52.9)% |
| <u>Profit (loss) before tax</u> | 175.1 | <u>(142.4)</u> | <u>(317.4)</u> | <u>―</u> | <u>―</u> |
| Income tax expenses | (66.9) | <u>(9.8)</u> | <u>57.2</u> | <u>(85.4)</u><u>%</u> | <u>(97.6)</u><u>%</u> |
| <u>Net profit (loss) for the year</u> | 108.1 | <u>(152.1)</u> | <u>(260.3)</u> | <u>―</u> | <u>―</u> |
| <u>Net profit (loss) for the year attributable to owners of the Company</u> | 107.9 | <u>(152.4)</u> | <u>(260.3)</u> | <u>―</u> | <u>―</u> |

---

In this section, the amount of change and percentage change based on Actual Exchange Rates are presented in "AER" (which is presented in accordance with IFRS) and percentage change based on Constant Exchange Rate (which is a non-IFRS measure) is presented in "CER". For additional information on CER change, see "Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations" in the Financial Appendix.

***Revenue***

Revenue for the fiscal year ended March 31, 2026 was JPY 4,505.7 billion (JPY -75.8 billion and -1.7% AER, -2.7% CER). The decline compared to the previous fiscal year was primarily attributable to a decrease in revenue in Neuroscience, one of our six key business areas. The decrease in Neuroscience was largely attributable to the continued impact from generic erosion of VYVANSE (for attention deficit hyperactivity disorder ("ADHD")) in the U.S. Revenue increased in our other five key business areas of Gastroenterology ("GI"), Rare Disease, Plasma-Derived Therapies ("PDT"), Oncology and Vaccines. Certain products faced headwinds due to the impact of the Medicare Part D redesign and 340B program expansion in the U.S., while there was stable demand in other regions and for other products. Revenue outside of our six key business areas was JPY 224.0 billion (JPY -33.4 billion and -13.0% AER, -15.9% CER).

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

***Revenue by Geographic Region***

The following shows revenue by geographic region:

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** |
| | **For the fiscal year ended**<br>**March 31,** | **For the fiscal year ended**<br>**March 31,** | AER | AER | CER |
| Revenue: | **2025** | **2026** | JPY Change | % Change | % Change |
| &nbsp;&nbsp;&nbsp;&nbsp;Japan | 418.5 | 433.1 | 14.6 | 3.5% | 3.4% |
| &nbsp;&nbsp;&nbsp;&nbsp;United States | 2379.7 | 2164.8 | (214.8) | (9.0)% | (7.7)% |
| &nbsp;&nbsp;&nbsp;&nbsp;Europe and Canada | 1055.3 | 1146.2 | 91.0 | 8.6% | 3.0% |
| &nbsp;&nbsp;&nbsp;Latin America | 235.8 | 254.1 | 18.3 | 7.8% | 4.9% |
| &nbsp;&nbsp;&nbsp;China | 191.7 | 195.1 | 3.4 | 1.8% | 1.4% |
| &nbsp;&nbsp;&nbsp;&nbsp;Asia (excluding Japan & China) | 99.4 | 98.7 | (0.7) | (0.7)% | (0.3)% |
| &nbsp;&nbsp;&nbsp;&nbsp;Russia/CIS | 72.4 | 79.7 | 7.4 | 10.2% | 0.7% |
| &nbsp;&nbsp;&nbsp;&nbsp;Other<sup>\*</sup> | 128.8 | 133.9 | 5.0 | 3.9% | 1.0% |
| &nbsp;&nbsp;&nbsp;&nbsp;Total | 4581.6 | 4505.7 | (75.8) | (1.7)% | (2.7)% |

---

\* Other includes the Middle East, Oceania and Africa.

***Revenue by Business Area***

The following shows revenue by business area:

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** |
| | **For the fiscal year ended**<br>**March 31,** | **For the fiscal year ended**<br>**March 31,** | AER | AER | CER |
| Revenue: | **2025** | **2026** | JPY Change | % Change | % Change |
| &nbsp;&nbsp;&nbsp;&nbsp;GI | 1357.0 | 1407.5 | 50.4 | 3.7% | 3.1% |
| &nbsp;&nbsp;&nbsp;&nbsp;Rare Diseases | 752.8 | 762.7 | 9.9 | 1.3% | (0.3)% |
| &nbsp;&nbsp;&nbsp;&nbsp;PDT | 1032.7 | 1057.5 | 24.9 | 2.4% | 1.9% |
| &nbsp;&nbsp;&nbsp;&nbsp;Oncology | 560.4 | 580.1 | 19.7 | 3.5% | 2.0% |
| &nbsp;&nbsp;&nbsp;&nbsp;Vaccines | 55.4 | 59.6 | 4.2 | 7.6% | 5.1% |
| &nbsp;&nbsp;&nbsp;&nbsp;Neuroscience | 565.8 | 414.3 | (151.5) | (26.8)% | (27.2)% |
| &nbsp;&nbsp;&nbsp;&nbsp;Other | 257.4 | 224.0 | (33.4) | (13.0)% | (15.9)% |
| &nbsp;&nbsp;&nbsp;&nbsp;Total | 4581.6 | 4505.7 | (75.8) | (1.7)% | (2.7)% |

---

Year-on-year change in revenue for this fiscal year in each of our business areas was primarily attributable to the following products:

***GI***

In GI, revenue was JPY 1,407.5 billion (JPY +50.4 billion and +3.7% AER, +3.1% CER).

Sales of ENTYVIO (for ulcerative colitis and Crohn's disease) were JPY 958.0 billion (JPY +43.9 billion and +4.8% AER, +4.2% CER). Sales in the U.S. were JPY 623.7 billion (JPY +4.5 billion and +0.7% AER). The increase was driven by growth of the subcutaneous formulation, offset by unfavorable foreign exchange rates against the U.S. dollar. Sales in Europe and Canada were JPY 256.7 billion (JPY +29.3 billion and +12.9% AER). The increase was primarily due to continued patient gains through an increased use of the subcutaneous formulation, accompanied by favorable foreign exchange rates against the Euro.

Sales of TAKECAB/VOCINTI (for acid-related diseases) were JPY 143.7 billion (JPY +12.9 billion and +9.9% AER, +9.6% CER). The increase was due to strong demand in China and Japan.

Sales of EOHILIA (for Eosinophilic Esophagitis) were JPY 8.8 billion (JPY +3.3 billion and +61.0% AER, +63.2% CER). The increase was due to strong demand in the U.S.

Sales of RESOLOR/MOTEGRITY (for chronic idiopathic constipation) were JPY 7.3 billion (JPY -12.2 billion and -62.7% AER, -62.8% CER). The decrease was primarily due to the impact of multiple generic entrants in the U.S. beginning in January 2025.

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

***Rare Diseases***

In Rare Diseases, revenue was JPY 762.7 billion (JPY +9.9 billion and +1.3% AER, -0.3% CER).

Sales of LIVTENCITY (for post-transplant cytomegalovirus infection/disease) were JPY 46.9 billion (JPY +13.9 billion and +42.2% AER, +41.0% CER). The increase was primarily attributable to continued performance in the U.S. market reflecting strong market penetration, complemented by continued geographical expansion in Europe and the Growth and Emerging Markets.

Sales of ADZYNMA (for congenital thrombotic thrombocytopenic purpura) were JPY 12.0 billion (JPY +4.9 billion and +68.8% AER, +65.1% CER). The increase was due to post-launch growth in Europe, reflecting an unmet need for treatment of an ultra-rare patient population.

Sales of VONVENDI (for von Willebrand Disease) were JPY 25.3 billion (JPY +4.3 billion and +20.8% AER, +18.6% CER). The increase was due to the expanded indication of VONVENDI, enabling prophylactic use for adult populations.

Sales of ADYNOVATE/ADYNOVI (for hemophilia A) were JPY 56.7 billion (JPY -7.9 billion and -12.3% AER, -13.1% CER). The decrease was primarily due to competitive pressure in the U.S.

Sales of ADVATE (for hemophilia A) were JPY 105.5 billion (JPY -6.2 billion and -5.6% AER, -6.8% CER). The decrease was primarily due to competitive pressure in the U.S.

***PDT***

In PDT, revenue was JPY 1,057.5 billion (JPY +24.9 billion and +2.4% AER, +1.9% CER).

Aggregate sales of immunoglobulin products, mainly used for the treatment of primary immunodeficiency, chronic inflammatory demyelinating polyneuropathy, and multifocal motor neuropathy, were JPY 790.6 billion (JPY +32.8 billion and +4.3% AER, +4.1% CER). The increase was driven by growth in subcutaneous immunoglobulin therapies, CUVITRU and HYQVIA, while sales of GAMMAGARD LIQUID/KIOVIG, which are intravenous immunoglobulin therapies, slightly increased, despite the impacts of the Medicare Part D redesign in the U.S. and unfavorable foreign exchange rates against the U.S. dollar.

Sales of FEIBA (for hemophilia A and B) were JPY 32.9 billion (JPY -6.6 billion and -16.6% AER, -17.7% CER). The decrease was driven by competitive pressure from recombinant therapies globally.

***Oncology***

In Oncology, revenue was JPY 580.1 billion (JPY +19.7 billion and +3.5% AER, +2.0% CER).

Sales of ADCETRIS (for malignant lymphomas) were JPY 140.2 billion (JPY +11.2 billion and +8.7% AER, +5.3% CER). The increase was led by strong demand in Europe and the Growth and Emerging Markets, accompanied by favorable foreign exchange rates against the Euro.

Sales of FRUZAQLA (for colorectal cancer) were JPY 55.1 billion (JPY +7.2 billion and +14.9% AER, +14.6% CER). The increase was due to the successful launch in Europe, Japan and the Growth and Emerging Markets, as it addressed a need for new treatment options in metastatic colorectal cancer. The increase was partially offset by a sales decline in the U.S., impacted by the Medicare Part D redesign.

Sales of ICLUSIG (for leukemia) were JPY 75.0 billion (JPY +4.3 billion and +6.1% AER, +5.6% CER). The increase was primarily due to a sales increase in Canada.

Sales of LEUPLIN/ENANTONE (for endometriosis, uterine fibroids, premenopausal breast cancer, prostate cancer, and other certain indications) were JPY 120.8 billion (JPY +1.5 billion and +1.3% AER, -0.4% CER). The increase was primarily due to favorable foreign exchange rates against the Euro.

Sales of NINLARO (for multiple myeloma) were JPY 82.1 billion (JPY -9.1 billion and -10.0% AER, -10.5% CER). The decrease was primarily due to intensified competition and decreased demand mainly in the U.S., partially offset by a sales increase in the Growth and Emerging Markets.

***Vaccines***

In Vaccines, revenue was JPY 59.6 billion (JPY +4.2 billion and +7.6% AER, +5.1% CER).

Sales of QDENGA (for prevention of dengue) were JPY 40.8 billion (JPY +5.2 billion and +14.6% AER, +10.7% CER). The increase was due to post-launch growth in the Growth and Emerging Markets, driven by higher demand.

Sales of other vaccine products in aggregate decreased primarily due to the continued temporary suspension of shipments of MR vaccine (for prevention of measles and rubella) in Japan.

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

***Neuroscience***

In Neuroscience, revenue was JPY 414.3 billion (JPY -151.5 billion and -26.8% AER, -27.2% CER).

Sales of VYVANSE/ELVANSE (for ADHD) were JPY 203.2 billion (JPY -147.4 billion and -42.0% AER, -43.0% CER). The decrease was due to the continued impact of generic erosion mainly in the U.S.

***Cost of Sales***

Cost of Sales was JPY 1,571.6 billion (JPY -8.6 billion and -0.5% AER, -1.9% CER). The decrease was primarily due to lower revenue as well as an adjustment to Cost of Sales recorded in the fiscal year ended March 31, 2025 following the implementation of an accounting process to recognize accumulated foreign currency impacts of inventories. However, these factors were largely offset by an increase in the cost ratio due to changes in product mix driven by generic erosion, particularly for VYVANSE in the U.S., and foreign exchange impacts from the depreciation of the Japanese yen against the Euro.

***Selling, General and Administrative (SG&A) Expenses***

SG&A Expenses were JPY 1,084.2 billion (JPY -20.6 billion and -1.9% AER, -2.5% CER). The decrease was primarily due to cost savings under the enterprise-wide efficiency program.

***Research and Development (R&D) Expenses***

R&D Expenses were JPY 675.9 billion (JPY -54.3 billion and -7.4% AER, -7.0% CER). The decrease was primarily due to lower expenses in various development programs resulting from the termination or progression of development activities, the co-development funding for mezagitamab recognized as a reduction of R&D expenses, and cost savings under the enterprise-wide efficiency program. This was partially offset by increased investment in late-stage pipeline programs, including zasocitinib and elritercept.

***Amortization and Impairment Losses on Intangible Assets Associated with Products***

Amortization and Impairment Losses on Intangible Assets Associated with Products were JPY 633.5 billion (JPY -9.7 billion and -1.5% AER, -1.7% CER). The decrease was due to lower amortization expenses (JPY -43.9 billion), mainly reflecting the completion of amortization of intangible assets related to VYVANSE/ELVANSE, partially offset by an increase in impairment losses (JPY +34.2 billion). Impairment losses for the fiscal year ended March 31, 2026 included JPY 58.2 billion related to the gamma delta T-cell therapy platform and associated oncology programs recorded following the decision to discontinue cell therapy research, and JPY 31.9 billion related to ALUNBRIG, a treatment for non-small cell lung cancer, recorded due to a reduction in future sales forecasts. Impairment losses for the fiscal year ended March 31, 2025 included JPY 27.8 billion recorded following the decision to terminate the development of TAK-186 and TAK-280 acquired through Maverick Therapeutics Inc., and JPY 21.5 billion recorded as a result of Phase 3 studies of soticlestat (TAK-935) failing to meet their primary endpoints.

***Other Operating Income***

Other Operating Income was JPY 24.7 billion (JPY -1.5 billion and -5.6% AER, -4.4% CER). The decrease was due to a gain arising from changes in the fair value of financial liabilities associated with contingent consideration agreement recorded in the fiscal year ended March 31, 2025 and other decreases in the fiscal year ended March 31, 2026 mostly offset by the increase in the divestiture gains recorded in the fiscal year ended March 31, 2026.

***Other Operating Expenses***

Other Operating Expenses were <u>JPY 559.0 billion (JPY +352.2 billion and +170.4% AER, +168.9% CER).</u> <u>The increase was primarily attributable to the recognition of provisions for legal proceedings of JPY 403.5 billion following the jury verdict in the AMITIZA antitrust litigation in the U.S. for the fiscal year ended March 31, 2026.</u> The increase was partially offset by a decrease of JPY 57.3 billion in restructuring expenses, reflecting lower costs under the enterprise-wide efficiency program.

***Operating Profit***

As a result of the above factors, Operating Profit was <u>JPY 6.2 billion (JPY -336.4 billion and -98.2% AER)</u>.

***Net Finance Expenses***

Net Finance Expenses were JPY 146.4 billion (JPY -17.1 billion and -10.5% AER, -7.5% CER). The decrease was primarily attributable to an impairment loss of JPY 18.9 billion related to the sale of Teva Takeda Pharma Ltd. shares recognized in the fiscal year ended March 31, 2025.

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

***Share of Loss of Investments Accounted for Using the Equity Method***

Share of Loss of Investments Accounted for Using the Equity Method was JPY 2.2 billion (JPY -1.8 billion and -45.4% AER, -52.9% CER).

***Income Tax Expenses***

Income Tax Expenses were <u>JPY 9.8 billion (JPY -57.2 billion and</u> <u>-85.4% AER, -97.6% CER)</u> <u>.</u> <u>The decrease was primarily attributable to a</u> JPY 58.4 billion <u>increase in Deferred Tax Assets resulting from the recognition of provisions for legal proceedings recorded following the jury verdict in the AMITIZA antitrust litigation in the U.S. for the fiscal year ended March 31, 2026.</u>

***<u>Net Profit (Loss) for the Year</u>***

<u>As a result of the above factors, Net Loss for the Year was</u> <u>JPY 152.1 billion</u> <u>(</u><u>JPY -260.3 billion, compared to Net Profit</u> <u>for the Year</u> <u>of JPY 108.1 billion for the fiscal year ended March 31, 2025</u><u>) and Net Loss for the Year attributable to owners of the Company was</u> <u>JPY 152.4 billion</u> <u>(</u><u>JPY -260.3 billion, compared to</u> <u>Net Profit for the Year attributable to owners of the Company</u> <u>of JPY 107.9 billion for the fiscal year ended March 31, 2025).</u>

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

**(iii) Results of Core Financial Measures (April 1, 2025 to March 31, 2026)** 

***Definition and Explanation of Core Financial Measures and Constant Exchange Rate Change***

In addition to the financial statements in accordance with IFRS, Takeda uses the concept of Core Financial Measures for measuring financial performance. These measures are not defined by International Financial Reporting Standards (IFRS). See "Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations" in the Financial Appendix for additional information.

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** |
| | **For the fiscal year ended**<br>**March 31,** | **For the fiscal year ended**<br>**March 31,** | AER | AER | CER |
| | **2025** | **2026** | JPY Change | % Change | % Change |
| Core revenue | 4579.8 | 4505.7 | (74.1) | (1.6)% | (2.6)% |
| Core operating profit | 1162.6 | 1172.5 | 9.8 | 0.8% | (0.9)% |
| Core net profit for the year | 775.8 | 814.4 | 38.6 | 5.0% | 2.9% |
| Core net profit for the year attributable to owners of the Company | 775.6 | 814.1 | 38.5 | 5.0% | 2.9% |
| Core EPS (yen) | 491 | 517 | 26 | 5.2% | 3.1% |

---

<br>***Core Revenue***

Core Revenue for the fiscal year ended March 31, 2026 was JPY 4,505.7 billion (JPY -74.1 billion and -1.6% AER, -2.6% CER). The decrease was primarily attributable to a decrease in revenue in Neuroscience, largely attributable to the continued impact from generic erosion of VYVANSE in the U.S.

Takeda's Growth and Launch Products<sup>\*</sup> totaled JPY 2,313.3 billion (JPY +111.4 billion and +5.1% AER, +4.5% CER).

\* Takeda's Growth and Launch Products for the fiscal year ended March 31, 2026

&nbsp;&nbsp;&nbsp;&nbsp;GI:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ENTYVIO, EOHILIA

&nbsp;&nbsp;&nbsp;&nbsp;Rare Diseases:&nbsp;&nbsp;&nbsp;&nbsp;TAKHZYRO, LIVTENCITY, ADZYNMA

&nbsp;&nbsp;&nbsp;&nbsp;PDT: &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Immunoglobulin products including GAMMAGARD LIQUID/KIOVIG, HYQVIA, and CUVITRU, &nbsp;&nbsp;&nbsp;&nbsp;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Albumin products including HUMAN ALBUMIN and FLEXBUMIN

&nbsp;&nbsp;&nbsp;&nbsp;Oncology:&nbsp;&nbsp;&nbsp;&nbsp; ALUNBRIG, FRUZAQLA

&nbsp;&nbsp;&nbsp;&nbsp;Vaccines:&nbsp;&nbsp;&nbsp;&nbsp; QDENGA

***Core Operating Profit***

Core Operating Profit for the fiscal year ended March 31, 2026 was JPY 1,172.5 billion (JPY +9.8 billion and +0.8% AER, -0.9% CER). The components of Core Operating Profit are as below:

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** |
| | **For the fiscal year ended**<br>**March 31,** | **For the fiscal year ended**<br>**March 31,** | AER | AER | CER |
| | **2025** | **2026** | JPY Change | % Change | % Change |
| Core revenue | 4579.8 | 4505.7 | (74.1) | (1.6)% | (2.6)% |
| Core cost of sales | (1581.8) | (1572.6) | 9.2 | (0.6)% | (1.9)% |
| Core selling, general and administrative (SG&A) expenses | (1105.0) | (1084.7) | 20.4 | (1.8)% | (2.5)% |
| Core research and development (R&D) expenses | (730.4) | (676.0) | 54.4 | (7.4)% | (7.0)% |
| Core operating profit | 1162.6 | 1172.5 | 9.8 | 0.8% | (0.9)% |

---

During the periods presented, these items fluctuated as follows:

***Core Cost of Sales***

Core Cost of Sales was JPY 1,572.6 billion (JPY -9.2 billion and -0.6% AER, -1.9% CER). The decrease was primarily due to lower revenue as well as an adjustment to Cost of Sales recorded in the fiscal year ended March 31, 2025 following the implementation of an accounting process to recognize accumulated foreign currency impacts of inventories. However, these factors were largely offset by an increase in the cost ratio due to changes in product mix driven by generic erosion, particularly for VYVANSE in the U.S., and foreign exchange impacts from the depreciation of the Japanese yen against the Euro.

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

***Core Selling, General and Administrative (SG&A) Expenses***

Core SG&A Expenses were JPY 1,084.7 billion (JPY -20.4 billion and -1.8% AER, -2.5% CER). The decrease was primarily due to cost savings under the enterprise-wide efficiency program.

***Core Research and Development (R&D) Expenses***

Core R&D Expenses were JPY 676.0 billion (JPY -54.4 billion and -7.4% AER, -7.0% CER. The decrease was primarily due to lower expenses in various development programs resulting from the termination or progression of development activities, the co-development funding for mezagitamab recognized as a reduction of R&D expenses, and cost savings under the enterprise-wide efficiency program. This was partially offset by increased investment in late-stage pipeline programs, including zasocitinib and elritercept.

***Core Net Profit for the Year***

Core Net Profit for the Year was JPY 814.4 billion (JPY +38.6 billion and +5.0% AER, +2.9% CER) and Core Net Profit attributable to owners of the Company was JPY 814.1 billion (JPY +38.5 billion and +5.0% AER, +2.9% CER) and are calculated from Core Operating Profit as below:

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** |
| | **For the fiscal year ended**<br>**March 31,** | **For the fiscal year ended**<br>**March 31,** | AER | AER | CER |
| | **2025** | **2026** | JPY Change | % Change | % Change |
| Core operating profit | 1162.6 | 1172.5 | 9.8 | 0.8% | (0.9)% |
| Core finance income and (expenses), net | (140.7) | (133.2) | 7.5 | (5.3)% | (1.9)% |
| Core share of profit (loss) of investments accounted for using the equity method | 1.1 | (0.1) | (1.3) | ― | (82.1)% |
| Core profit before tax | 1023.1 | 1039.2 | 16.1 | 1.6% | (0.9)% |
| Core income tax expenses | (247.3) | (224.8) | 22.5 | (9.1)% | (12.8)% |
| Core net profit for the year | 775.8 | 814.4 | 38.6 | 5.0% | 2.9% |
| Core net profit for the year attributable to owners of the Company | 775.6 | 814.1 | 38.5 | 5.0% | 2.9% |

---

During the periods presented, these items fluctuated as follows:

***Core Net Finance Expenses***

Core Net Finance Expenses were JPY 133.2 billion (JPY -7.5 billion and -5.3% AER, -1.9% CER).

***Core Share of Profit (Loss) of Investments Accounted for Using the Equity Method***

Core Share of Loss of Investments Accounted for Using the Equity Method was JPY -0.1 billion (JPY -1.3 billion) for the fiscal year ended March 31, 2026.

***Core Profit Before Tax***

Core Profit Before Tax was JPY 1,039.2 billion (JPY +16.1 billion and +1.6% AER, -0.9% CER).

***Core Income Tax Expenses***

Core Income Tax Expenses were JPY 224.8 billion (JPY -22.5 billion and -9.1% AER, -12.8% CER). The decrease was primarily due to the reassessment of recoverability of deferred tax assets leading to lower core tax expenses during the fiscal year ended March 31, 2026.

***Core EPS***

Core EPS was JPY 517 (JPY +26 and +5.2% AER, +3.1% CER).

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

**(2) Consolidated Financial Position**

---

| | | | |
|:---|:---|:---|:---|
| | **Billion JPY** | **Billion JPY** | **Billion JPY** |
| | **As of** | **As of** | **Change** |
| | **March 31, 2025** | **March 31, 2026** | **Change** |
| Total Assets | 14248.3 | <u>15511.5</u> | <u>1263.2</u> |
| Total Liabilities | 7312.4 | <u>8080.9</u> | <u>768.5</u> |
| Total Equity | 6936.0 | <u>7430.6</u> | <u>494.7</u> |

---

***Assets***

Total Assets as of March 31, 2026 were <u>JPY 15,511.5 billion</u> (<u>JPY +1,263.2 billion</u>). Goodwill, Inventories, and Property, Plant and Equipment increased (JPY +484.6 billion, JPY +179.3 billion, and JPY +152.4 billion, respectively), mainly due to the effect of foreign currency translation. Deferred Tax Assets increased <u>(</u><u>JPY +175.5 billion),</u> <u>primarily due to a JPY 58.4 billion increase in Deferred Tax Assets resulting from the recognition of provisions for legal proceedings recorded following the jury verdict in the AMITIZA antitrust litigation in the U.S.</u> and amortization of intangible assets as well as the reassessment of the recoverability of Deferred Tax Assets. Trade and Other Receivables increased (JPY +134.8 billion), primarily due to higher receivables resulting from a reduction in the trade receivables sales program in the U.S., as well as the effect of foreign currency translation. Total Other Financial Assets increased (JPY +110.2 billion), mainly driven by changes in the fair value of cross currency interest rate swaps in Japan. In addition, Cash and Cash Equivalents increased (JPY +209.9 billion). These increases were partially offset by the decrease of Intangible Assets (JPY -212.2 billion), mainly due to amortization and impairment.

***Liabilities***

Total Liabilities as of March 31, 2026 were <u>JPY 8,080.9 billion</u> <u>(</u><u>JPY +768.5 billion</u><u>)</u>. <u>Total Provisions increased (</u><u>JPY +467.7 billion</u><u>) primarily due to legal proceedings following the jury verdict in the AMITIZA antitrust litigation in the U.S.</u> Total Bonds and Loans were JPY 4,881.8 billion<sup>\*</sup>, which increased (JPY +366.6 billion) mainly due to the foreign currency effects, as well as the issuances of unsecured JPY denominated senior bonds, unsecured U.S. dollar-denominated senior guaranteed notes and new Bilateral Loans, which were partially offset by redemption and repayment of certain bonds and loans.

\* The carrying amount of Bonds was JPY 4,656.8 billion and that of Loans was JPY 225.0 billion as of March 31, 2026. The breakdown of Bonds and Loans' carrying amount is as follows:

<u>Bonds</u>:

---

| | | | |
|:---|:---|:---|:---|
| **Name of Bond**<br> **(Face Value if Denominated in Foreign Currency)** | **Issuance** | **Maturity** | **Carrying Amount**<br>**(Billion JPY)** |
| Unsecured US Dollar Denominated Senior Notes<br>(USD 500 million) | June 2015 | June 2045 | 81.3 |
| Unsecured US Dollar Denominated Senior Notes<br>(USD 1,500 million) | September 2016 | September 2026 | 237.7 |
| Unsecured Euro Denominated Senior Notes<br>(EUR 3,000 million) | November 2018 | November 2026 ~<br>November 2030 | 547.6 |
| Unsecured US Dollar Denominated Senior Notes<br>(USD 1,750 million) | November 2018 | November 2028 | 278.4 |
| Unsecured US Dollar Denominated Senior Notes<br>(USD 7,000 million) | July 2020 | March 2030 ~<br>July 2060 | 1111.1 |
| Unsecured Euro Denominated Senior Notes<br>(EUR 3,600 million) | July 2020 | July 2027 ~<br>July 2040 | 655.8 |
| Unsecured JPY Denominated Senior Bonds | October 2021 | October 2031 | 249.6 |
| Hybrid Bonds (Subordinated Bonds) | June 2024 | June 2084 | 458.4 |
| Unsecured US Dollar Denominated Senior Notes<br>(USD 3,000 million) | July 2024 | July 2034 ~<br>July 2064 | 473.8 |
| Unsecured JPY Denominated Senior Bonds | June 2025 | June 2030 ~<br>June 2035 | 183.6 |
| Unsecured US Dollar Denominated Senior Notes<br>(USD 2,400 million) | July 2025 | July 2035 ~<br>July 2055 | 379.4 |
| Total |  |  | 4656.8 |

---

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

<u>Loans</u>:

---

| | | | |
|:---|:---|:---|:---|
| **Name of Loan**<br> **(Face Value if Denominated in Foreign Currency)** | **Execution** | **Maturity** | **Carrying Amount**<br>**(Billion JPY)** |
| Bilateral Loans | March 2023 ~ <br>March 2026 | March 2029 ~<br>March 2034 | 185.0 |
| Syndicated Hybrid Loans (Subordinated Loans) | October 2024 | October 2084 | 40.0 |
| Other |  |  | 0.0 |
| Total |  |  | 225.0 |

---

On April 25, 2025, Takeda repaid JPY 10.0 billion in Bilateral Loans falling due. On June 12, 2025, Takeda issued JPY 184.0 billion in unsecured JPY denominated senior bonds ("JPY Bonds") with maturity dates ranging from June 12, 2030, to June 12, 2035. The proceeds of the JPY Bonds were used to redeem commercial paper. Following this, on June 23, 2025, Takeda redeemed USD 800 million of unsecured U.S. dollar-denominated senior notes on their maturity date. Takeda has also rolled over USD 500 million Bilateral Loan, which was originally drawn down on March 31, 2025, on a monthly basis until July 3, 2025.

On July 2, 2025, Takeda issued unsecured U.S. dollar-denominated senior guaranteed notes (the "USD Notes") in an aggregate principal amount of USD 2,400 million with maturity dates of July 7, 2035 and July 7, 2055, through its indirect wholly owned finance subsidiary Takeda U.S. Financing, Inc. The proceeds of the USD Notes were primarily used to repay USD 500 million Bilateral Loan on July 3, 2025, and redeem commercial paper drawings in July 2025.

On March 31, 2026, Takeda repaid JPY 75.0 billion in Bilateral Loans falling due and on the same day entered into new Bilateral Loans of JPY 60.0 billion maturing on March 31, 2034. Takeda also entered into commitment facilities of JPY 350.0 billion and USD 2,100 million. These commitment facilities are effective from March 31, 2026 for five years at minimum. In connection with these new facilities, Takeda's existing commitment facility of JPY 700.0 billion expiring in September 2026 was cancelled on the same date. The purpose of the new facilities is for general business use.

\*Amounts presented in the above explanation for Bonds and Loans are based on the principal amount.

***Equity***

Total Equity as of March 31, 2026 was <u>JPY 7,430.6 billion (</u><u>JPY +494.7 billion</u><u>)</u>. The increase of Other Components of Equity (JPY +945.5 billion) was mainly due to a change in currency translation adjustments reflecting the depreciation of the Japanese yen. This increase was partially offset by the decrease in Retained Earnings (JPY -475.2 billion), driven by the decrease of JPY 312.5 billion related to dividend payments<u>, as well as Net Loss for the Year of</u> <u>JPY 152.1 billion</u>.

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

**(3) Consolidated Cash Flows**

---

| | | | |
|:---|:---|:---|:---|
| | **Billion JPY** | **Billion JPY** | **Billion JPY** |
| | **For the fiscal year ended March 31,** | **For the fiscal year ended March 31,** | **For the fiscal year ended March 31,** |
| | **2025** | **2026** | **Change** |
| Net cash from operating activities | 1057.2 | 1041.4 | (15.8) |
| Net cash used in investing activities | (367.1) | (369.1) | (2.1) |
| Net cash used in financing activities | (751.4) | (496.8) | 254.6 |
| Net increase (decrease) in cash and cash equivalents | (61.3) | 175.5 | 236.8 |
| Cash and cash equivalents at the beginning of the year | 457.8 | 385.1 | (72.7) |
| Effects of exchange rate changes on cash and cash equivalents | (11.4) | 34.5 | 45.9 |
| Cash and cash equivalents at the end of the year | 385.1 | 595.1 | 209.9 |

---

***Net Cash from Operating Activities***

Net Cash from Operating Activities was JPY 1,041.4 billion (JPY -15.8 billion). The decrease was mainly due to unfavorable impacts resulting from changes in assets and liabilities adjusted for provisions, primarily driven by changes in Other Financial Liabilities. The decrease was largely offset by an increase in net cash inflows from Settlement of Forward Exchange Contracts, Net and favorable impacts resulting from <u>Net Profit (Loss) for the Year</u> adjusted for non-cash items and other adjustments.

***Net Cash used in Investing Activities***

Net Cash used in Investing Activities was JPY 369.1 billion (JPY +2.1 billion), essentially flat compared to the fiscal year ended March 31, 2025, reflecting offsetting changes in individual investing activities, including an increase in cash outflows used in Acquisition of Intangible Assets and a decrease in cash outflows from Acquisition of Investments.

***Net Cash used in Financing Activiti*es** 

Net Cash used in Financing Activities was JPY 496.8 billion (JPY -254.6 billion). The decrease was mainly due to higher net cash inflows from the issuance and repayments of bonds and loans.

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

**<u>(4) Other</u>**

<u>On May 18, 2026 (U.S. Eastern Time), a jury in the U.S. District Court for the District of Massachusetts returned a verdict against Takeda Pharmaceutical Company Limited, Takeda Pharmaceuticals U.S.A., Inc., and Takeda Pharmaceuticals America, Inc. in the AMITIZA (lubiprostone) antitrust litigation and awarded plaintiffs USD 884,943,990 in single damages. Under U.S. antitrust law, the damages awarded to the wholesaler class (USD 474,897,965 in single damages) and individual retailers (collectively USD 346,837,646 in single damages) will be automatically trebled upon entry of judgment, while the damages awarded to the third-party payor class remain subject to further proceedings prior to entry of judgment. As of March 31, 2026, Takeda had provisions for legal proceedings of JPY 403.5 billion related to this matter.</u>

<u>The amount of any liability that may ultimately be imposed on Takeda has not yet been finalized. Takeda intends to pursue post-trial motions and an appeal and will seek a stay of execution of the judgment during the pendency of the appeal.</u>

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

**(5) Outlook for the Fiscal Year Ending March 31, 2027**

<u>Takeda does not expect its FY2026 financial forecast or Management Guidance to be materially impacted by the proceedings of AMITIZA antitrust litigation during FY2026. We will continue to assess the progress and financial impacts, depending on the district court judgment expected through the second half of the calendar year 2026 and proceedings thereafter, and provide an update as necessary.</u>

Consolidated forecast for the fiscal year ending March 31, 2027 (FY2026) is as below:

**Consolidated Forecast for the Fiscal Year Ending March 31, 2027 (FY2026)**

---

| | | | | |
|:---|:---|:---|:---|:---|
| | | | Billion JPY or percentage | Billion JPY or percentage |
| |<br>**FY2025**<br>**Actual Results** |<br>**FY2026**<br>**Forecast** | **JPY Change** | **% Change** |
| Revenue | 4505.7 | 4640.0 | 134.3 | 3.0% |
| Operating profit | <u>6.2</u> | 420.0 | <u>413.8</u> | <u>ー</u> |
| <u>Profit (loss) before tax</u> | <u>(142.4)</u> | 252.0 | <u>394.4</u> | <u>ー</u> |
| <u>Net profit (loss) for the year</u><br>(attributable to owners of the Company) | <u>(152.4)</u> | 166.0 | <u>318.4</u> | <u>ー</u> |
| EPS (JPY) | <u>(96.75)</u> | 104.26 | <u>201.01</u> | <u>ー</u> |
| Core revenue<sup>\*</sup> | 4505.7 | 4640.0 | 134.3 | 3.0% |
| Core operating profit<sup>\*</sup> | 1172.5 | 1160.0 | (12.5) | (1.1)% |
| Core EPS (JPY)<sup>\*</sup> | 517 | 472 | (45) | (8.7)% |

---

\* Please refer to "Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations" in the Financial Appendix for the definition.

[Revenue]

Takeda expects FY2026 revenue to be JPY 4,640.0 billion, an increase of JPY 134.3 billion, or 3.0%, from FY2025. The increase in revenue from New Launches<sup>\*1</sup> and Core In-Line Brands<sup>\*2,</sup> together with a favorable year-on-year exchange impact reflecting yen depreciation from FY2025, is expected to more than offset the decrease in revenue from other products.

Because Takeda does not expect any significant non-core items that require adjustment, the Core Revenue forecast for FY2026 is the same as the Revenue forecast.

[Operating Profit]

Operating Profit is <u>expected to increase by JPY 413.8 billion to JPY 420.0 billion, primarily attributable to the recognition of provisions for legal proceedings following the jury verdict in the AMITIZA antitrust litigation recorded in Other Operating Expenses in FY2025</u>. Higher revenue and lower amortization expenses of intangible assets due to the conclusion of amortization for VYVANSE/ELVANSE in FY2025 will also contribute to the increase of Operating Profit. Cost savings from the transformation program designed to strengthen our competitiveness and accelerate future growth are expected to be fully reinvested to support new product launches and further investment in R&D, particularly in late-stage pipeline programs. Restructuring expenses are expected to increase due to a transformation program initiated in 2026.

Core Operating Profit is expected to be JPY 1,160.0 billion, a decrease of JPY 12.5 billion, or 1.1%.

[Net profit for the Year (attributable to owners of the Company)]

Net profit for the Year (attributable to owners of the Company) is <u>expected to be JPY 166.0 billion, an increase of JPY 318.4 billion</u>. Profit Before Tax is <u>expected to increase by JPY 394.4 billion to JPY 252.0 billion</u>, reflecting the increase in Operating Profit, partially offset by an increase in net finance expenses. The effective tax rate is assumed to be approximately 34%.

Reported EPS is <u>expected to be JPY 104.26, an increase of JPY 201.01</u>, and Core EPS is expected to be JPY 472, a decrease of JPY 45, or 8.7%.

\*1 New Launches refers to select products launched within past 5 years (EOHILIA, LIVTENCITY, ADZYNMA, FRUZAQLA, QDENGA) and upcoming launch products rusfertide, oveporexton, and zasocitinib. Revenue from upcoming launches subject to regulatory approvals.

\*2 Core In-line Brands refers to select products launched 6 or more years ago that generate over JPY 100.0 billion in annual revenue and are actively promoted (ENTYVIO, GATTEX/REVESTIVE,TAKECAB/VOCINTI, TAKHZYRO, immunoglobulin products, albumin products, ADCETRIS).

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

**Major assumptions used in preparing the FY2026 Forecast**

---

| | | |
|:---|:---|:---|
| |<br>**FY2025**<br>**Actual Results** | Billion JPY or percentage<br>**FY2026**<br>**Forecast** |
| FX rates | 1 USD = 150 JPY<br>1 Euro = 174 JPY <br>1 RUB = 1.9 JPY <br>1 CNY = 21.1 JPY <br>1 BRL = 27.6 JPY | 1 USD = 156 JPY<br>1 Euro = 182 JPY<br>1 RUB = 2.0 JPY<br>1 CNY = 22.4 JPY<br>1 BRL = 29.5 JPY |
| Cost of sales | (1571.6) | (1625.0) |
| SG&A expenses | (1084.2) | (1093.0) |
| R&D expenses | (675.9) | (762.0) |
| Amortization of intangible assets associated with products | (504.3) | (413.5) |
| Impairment of intangible assets associated with products<sup>\*2</sup> | (129.3) | (100.0) |
| Other operating income | 24.7 | 2.5 |
| Other operating expenses<sup>\*3</sup> | <u>(559.0)</u> | (229.0) |
| Finance income and (expenses), net | (146.4) | (170.0) |
| Adjusted free cash flow<sup>\*1, 4</sup> | 684.5 | 650.0 to 750.0 |
| Capital expenditures (cash flow base)<sup>\*4</sup> | (410.9) | (330.0) to (380.0) |
| Depreciation and amortization (excluding intangible assets associated with products) | (216.8) | (235.0) |
| Cash tax rate on adjusted EBITDA (excluding divestitures) <sup>\*1</sup> | ~12% | Low 10s% |

---

\*1 Please refer to "Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations" in the Financial Appendix for the definition.

\*2 Includes in-process R&D.

\*3 Includes <u>the recognition of provisions for legal proceedings following the jury verdict in the AMITIZA antitrust litigation of JPY 403.5 billion in FY2025 actual results</u>, and restructuring expense primarily related to the enterprise-wide efficiency program of JPY 70.8 billion in FY2025 actual results and the transformation program of JPY 170.0 billion in FY2026 forecast.

\*4 Includes JPY 184.7 billion upfront payment to Innovent Biologics Inc in FY2025 actual results.

**Management Guidance**

Takeda uses change in Core Revenue, Core Operating Profit and Core EPS at Constant Exchange Rate (CER) basis as its Management Guidance.

---

| | |
|:---|:---|
| | **FY2026 Management Guidance**<br>**CER % Change**<sup>\*</sup> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Core revenue | Low-single digit % decline |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Core operating profit | 5% to 8% decline |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Core EPS | Mid-teens % decline |

---

\* Please refer to "Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations" in the Financial Appendix for the definition.

**Forward looking statements**

All forecasts in this document are based on information currently available to management, and do not represent a promise or guarantee to achieve these forecasts. Various uncertain factors could cause actual results to differ, such as changes in the business environment and fluctuations in foreign exchange rates. See "Important Notice—Forward-Looking Statements" in the Financial Appendix, including the documents mentioned therein. Should any significant event occur which requires the forecast to be revised, the Company will disclose it in a timely manner.

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

**(6) Capital Allocation Policy and Dividends for the Fiscal Year Ended March 31, 2026 and Ending March 31, 2027**

**(i) Capital Allocation Policy**

Guided by our vision to discover and deliver life-transforming treatments, and supported by our balance sheet (maintaining solid investment grade credit ratings; targeting 2x adjusted net debt to adjusted EBITDA ratio\*), we will allocate capital to deliver sustainable value to patients and attractive returns to our shareholders.

Takeda's policy in the allocation of capital is as follows:

&nbsp;&nbsp;&nbsp;&nbsp;• Invest in growth drivers; and

&nbsp;&nbsp;&nbsp;&nbsp;• Shareholder returns.

With respect to "Invest in growth drivers", Takeda makes strategic investments in new product launches, internal and external opportunities to enhance its pipeline, and plasma-derived therapies. With regard to "Shareholder returns", Takeda has adopted a progressive dividend policy of increasing or maintaining the annual dividend per share each year, alongside share buybacks when appropriate.

\* Please refer to "Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations" in the Financial Appendix for the definition.

**(ii) Dividend**

Takeda is strongly committed to shareholder returns with the dividend as a key component.

[FY2025] 200 yen per share

Year-end dividend per share: 100 yen

Together with the interim dividend of 100 yen per share, the annual dividend will be 200 yen per share.

[FY2026 guidance] 204 yen per share

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

**2. Management Policy**

**(1)Basic Management Policy**

Our corporate philosophy tells the story of Takeda — who we are, what we do, how we do it and why it matters. As we embark on Takeda's next era, we will stay committed to delivering on our generational promise to make our world healthier.

Our purpose is to contribute to better health for people and a brighter future for the world. We do this through the pursuit of our vision to discover and deliver life-transforming treatments. Our employees are united in our purpose and grounded in the values of Integrity, Honesty, Fairness and Perseverance, which have defined us for 245 years. This is how we create long-term value for patients, shareholders and society while sustaining positive impact for our people, the communities we serve and the planet we share.

**(2) Business Environment, Mid- to Long-Term Business Strategy and Issues to Be Addressed**

**Business Environment**

The external environment for global biopharmaceutical companies remains complex, defined by continued geopolitical fragmentation and international policy uncertainties. Ongoing tensions, shifting alliances and evolving trade policies are sustaining ambiguities for cross-border operations and long-term investment planning. These dynamics increasingly influence regulatory approaches, supply chain resilience and the overall stability of global health care markets.

Across major geographies, pricing pressure remains a defining challenge. As governments shift budget priorities toward defense and confront slower growth, inflation, and broader fiscal pressures, public health care spending is coming under increasing strain and further intensifying pricing pressures. While governments would like to expand patient access, health care budgets continue to be more constrained, leading to tighter reimbursement frameworks and slower market access pathways around the world. In the U.S., continued implementation of pricing-related policy changes adds further unpredictability for innovative therapies and may influence future investment decisions. In Europe and Japan, structural budget limitations continue to cap growth in several therapeutic areas.

At the same time, the pace of scientific and technological change is accelerating rapidly. Advances in science, data analytics, automation and artificial intelligence are reshaping how we discover, develop and deliver new medicines. In this context, Takeda is prioritizing focused execution, strengthening supply and operating discipline, and advancing a technology-forward, human-centric transformation, while safeguarding scientific rigor and patient trust.

Takeda's continued progress in scientific discovery positions us well. Our work across targeted therapeutic areas and our growing use of digital tools strengthen our ability to deliver innovative medicines with greater speed and efficiency. As external pressures intensify, our commitment to patients — and to advancing science responsibly — remains foundational to how we navigate the years ahead.

**Vision for Takeda's Future**

In the face of rapid scientific advancement and complexity in global health care, Takeda's strategy is designed to deliver near-term, as we prepare to launch a series of new, transformative medicines, while also positioning us for accelerated growth. In 2025, we achieved strong Phase 3 results across our three leading late-stage assets — oveporexton, rusfertide and zasocitinib — each with the potential for multi-billion-dollar revenue. These assets not only demonstrate the depth and rigor of our pipeline but also reflect our ability to deliver against demanding regulatory and commercial milestones.

As we look towards the future, we are operating with two horizons in view: horizon one strengthens our competitiveness and builds a growth engine through investment and transformation near-term; horizon two delivers accelerated growth in the mid-to-long term as we scale for the first wave of launches (oveporexton, rusfertide, zasocitinib), while preparing for the next wave from our other late-stage assets, that will expand our impact for patients and create long-term growth for shareholder.

**Horizon One: Transforming for Growth** 

The first horizon is focused on advancing product launches, executing on a robust late-stage pipeline and transforming how we operate.

Since January, we have implemented changes to our organizational structure and ways of working as the final phase of the CEO transition plan. CEO-Elect Julie Kim established her leadership team and redesigned the organization to bring leaders and teams closer to patients and customers. And as we build our new teams, which includes standardizing, simplifying and accelerating adoption of advanced technologies, we are also instilling a focus on speed and performance while remaining grounded in our values.

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

For more information on our major activities and progress on R&D from April 2025 to date, please see our discussion of Pipeline and R&D Activities in our Quarterly Financial Report for the Year Ended March 31, 2026.

In this first horizon we are ensuring the necessary resources to flawlessly execute on the multiple launches that we expect in the next 12 months. This horizon is also about advancing our robust pipeline in our key therapeutic areas of Gastrointestinal and Inflammation, Neuroscience and Oncology, including five late-stage assets, and keeping brands, such as ENTYVIO and GAMMAGARD LIQUID/KIOVIG, resilient and competitive, despite challenging market dynamics.

Cost discipline and strategic investment are the hallmarks of this horizon. We are pursuing more than JPY 200 billion in annualized gross savings by fiscal year 2028, reinvesting efficiencies into launches, pipeline development and technology — a commitment to maintaining financial discipline while positioning for accelerated growth. Generating strong adjusted Free Cash Flow\* is core to our strategy, allowing us to fulfill our commitments and return value to shareholders.

\* Please refer to "Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations" in the Financial Appendix for the definition.

**Horizon Two: Growth Acceleration**

Through the disciplined choices and a strong launch focus in Horizon One, we are building an engine to unlock Takeda's next era of growth in Horizon Two — shifting from a maturing portfolio to a new cohort of blockbuster brands. This new cohort will be led by oveporexton, rusfertide and zasocitinib, followed by additional new product introductions from our late-stage pipeline. The new product revenues plus a steadfast commitment to operating with greater efficiency will position us to grow sustainably beyond the anticipated challenges of our mature portfolio.

The company also remains committed to scaling its positive impact on patients and society by deploying next-generation science and technology to redefine what is possible, both in the medicines it delivers and in the outcomes it helps enable.

**Technology as the Engine of Transformation**

In this new era, technology is not a standalone objective. It is central to Takeda's transformation and inseparable from the way we discover, develop and deliver value — acting as multipliers for curiosity, creativity and the collective expertise of our teams.

Artificial intelligence, digital platforms and advanced analytics are now embedded into every stage of the value chain. These technologies accelerate timelines, elevate the quality of decision-making and bring new standards of care to patients faster. Our digital capabilities also help break down silos, fostering a culture of rapid learning, cross-functional agility and operational excellence.

Across Takeda, technology is not just a tool, it is a collaborator that expands the possibilities. By equipping our people with advanced platforms and data-driven insights, we empower them to focus on what matters most: meeting urgent patient needs, driving impact, fueling our growth and building lasting trust with all stakeholders.

**A Future Defined by Collaboration and Impact**

We know that meaningful progress in health care is the product of partnership. Takeda's vision for the future continues to be grounded in collaboration — within our own teams, across the biopharmaceutical sector and in concert with the broader scientific, regulatory and patient communities. We actively seek diverse voices to co-create solutions, whether through public–private partnerships, global alliances or local community engagement.

Our commitment to collaboration extends to how we build the next wave of innovation. Open science, shared platforms and coalition-building are central to addressing the complexity of tomorrow's health challenges. By working together, across sectors and geographies, we will expand access, drive equitable outcomes and amplify the positive impact of our efforts for generations to come.

**Financial Prospects**

Built on a strong financial base and robust strategic framework, our financial approach is designed to support sustainable growth and long-term value creation.

Over the near-to-mid term, we are focused on delivering key regulatory and commercial milestones for a number of high-potential launches, including oveporexton, rusfertide and zasocitinib, and to advance the broader late-stage pipeline, underpinned by the resilience and competitiveness of our maturing established portfolio.

To protect profitability, we will optimize our organizational structure and leverage data and technology to enhance decision-making and operational efficiency. We will also reduce Other Operating Expenses, including restructuring expenses, and lower Finance Expenses through debt reduction to improve reported net profit, supporting dividends and helping deliver ROE above 5%.

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

Disciplined capital allocation and cash generation will enable robust adjusted Free Cash Flow\* to fund continued investment in growth, alongside further debt reduction and maintaining a progressive dividend policy, while enhancing capital efficiency.

In the long term, we expect new products to replace the current maturing portfolio as the primary drivers of growth acceleration. Topline growth and continued cost discipline should position us to improve profitability, with Core Operating Profit\* margin progressing toward low-to-mid 30s%. We also target an adjusted net debt to adjusted EBITDA ratio\* of 2x, further strengthening our financial position and enhancing capital flexibility for further investment in sustainable growth.

Taken together, these actions are expected to support sustained improvements in financial performance. Over time, this is expected to contribute to the continued enhancement of enterprise value and competitive total shareholder returns.

\* Please refer to "Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations" in the Financial Appendix for the definition.

**3. Basic Approach to the Selection of Accounting Standards**

Takeda has been applying International Financial Reporting Standards ("IFRS") since the fiscal year ended March 31, 2014 with the aim of improving the comparison of financial information with global pharmaceutical companies, increasing financing options, and allowing Takeda to unify accounting treatment across the group.

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

**4. Consolidated Financial Statements [IFRS] and Major Notes**

**(1) Consolidated Statements of Profit or Loss**

---

| | | |
|:---|:---|:---|
| | **JPY (millions)** | **JPY (millions)** |
| | **For the year ended March 31,** | **For the year ended March 31,** |
| | **2025** | **2026** |
| Revenue | 4581551 | 4505720 |
| Cost of sales | (1580217) | (1571588) |
| Selling, general and administrative expenses | (1104766) | (1084215) |
| Research and development expenses | (730227) | (675924) |
| Amortization and impairment losses on intangible assets associated with products | (643233) | (633544) |
| Other operating income | 26212 | 24747 |
| Other operating expenses | (206733) | <u>(558979)</u> |
| Operating profit | 342586 | <u>6217</u> |
| Finance income | 46549 | 211177 |
| Finance expenses | (210065) | (357572) |
| Share of loss of investments accounted for using the equity method | (3986) | (2177) |
| <u>Profit (loss) before tax</u> | 175084 | <u>(142355)</u> |
| Income tax expenses | (66941) | <u>(9770)</u> |
| <u>Net profit (loss) for the year</u> | 108143 | <u>(152125)</u> |
| Attributable to: |  |  |
| &nbsp;&nbsp;Owners of the Company | 107928 | <u>(152390)</u> |
| &nbsp;&nbsp;Non-controlling interests | 215 | 264 |
| <u>Net profit (loss) for the year</u> | 108143 | <u>(152125)</u> |
| Earnings per share (JPY) |  |  |
| &nbsp;&nbsp;<u>Basic earnings (loss) per share</u> | 68.36 | <u>(96.75)</u> |
| &nbsp;&nbsp;<u>Diluted earnings (loss) per share</u> | 67.23 | <u>(96.75)</u> |

---

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

**(2) Consolidated Statements of Comprehensive Income**

---

| | | |
|:---|:---|:---|
| | **JPY (millions)** | **JPY (millions)** |
| | **For the year ended March 31,** | **For the year ended March 31,** |
| | **2025** | **2026** |
| <u>Net profit (loss) for the year</u> | 108143 | <u>(152125)</u> |
| Other comprehensive income (loss) |  |  |
| Items that will not be reclassified to profit or loss: |  |  |
| &nbsp;&nbsp;&nbsp;Changes in fair value of financial assets measured at fair value through other comprehensive income | (12311) | (4976) |
| &nbsp;&nbsp;&nbsp;Remeasurement of defined benefit pension plans | (7046) | 1914 |
|  | (19357) | (3062) |
| Items that may be reclassified subsequently to profit or loss: |  |  |
| &nbsp;&nbsp;&nbsp;Exchange differences on translation of foreign operations | (153345) | 903895 |
| &nbsp;&nbsp;&nbsp;Cash flow hedges | (956) | 28950 |
| &nbsp;&nbsp;&nbsp;Hedging cost | 7963 | 3159 |
| &nbsp;&nbsp;&nbsp;Share of other comprehensive loss of investments accounted for using the equity method | (145) | (541) |
|  | (146484) | 935463 |
| Other comprehensive income (loss) for the year, net of tax | (165841) | 932401 |
| Total comprehensive income (loss) for the year | (57698) | <u>780275</u> |
| Attributable to: |  |  |
| &nbsp;&nbsp;&nbsp;Owners of the Company | (57852) | <u>779963</u> |
| &nbsp;&nbsp;&nbsp;Non-controlling interests | 154 | 313 |
| Total comprehensive income (loss) for the year | (57698) | <u>780275</u> |

---

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

**(3) Consolidated Statements of Financial Position**

---

| | | |
|:---|:---|:---|
| | **JPY (millions)** | **JPY (millions)** |
| | **As of March 31, 2025** | **As of March 31, 2026** |
| **<u>ASSETS</u>** | | |
| Non-current assets: |  |  |
| &nbsp;&nbsp;&nbsp;Property, plant and equipment | 1968209 | 2120639 |
| &nbsp;&nbsp;&nbsp;Goodwill | 5324430 | 5809010 |
| &nbsp;&nbsp;&nbsp;Intangible assets | 3631560 | 3419348 |
| &nbsp;&nbsp;&nbsp;Investments accounted for using the equity method | 10802 | 8796 |
| &nbsp;&nbsp;&nbsp;Other financial assets | 351124 | 439941 |
| &nbsp;&nbsp;&nbsp;Other non-current assets | 70282 | 77010 |
| &nbsp;&nbsp;&nbsp;Deferred tax assets | 370745 | <u>546260</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;Total non-current assets | 11727152 | <u>12421004</u> |
| Current assets: |  |  |
| &nbsp;&nbsp;&nbsp;Inventories | 1217349 | 1396620 |
| &nbsp;&nbsp;&nbsp;Trade and other receivables | 709465 | 844312 |
| &nbsp;&nbsp;&nbsp;Other financial assets | 20476 | 41888 |
| &nbsp;&nbsp;&nbsp;Income taxes receivable | 15789 | 32036 |
| &nbsp;&nbsp;&nbsp;Other current assets | 159603 | 162638 |
| &nbsp;&nbsp;&nbsp;Cash and cash equivalents | 385113 | 595054 |
| &nbsp;&nbsp;&nbsp;Assets held for sale | 13397 | 17955 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total current assets | 2521192 | 3090503 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total assets | 14248344 | <u>15511506</u> |

---

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

---

| | | |
|:---|:---|:---|
| | **JPY (millions)** | **JPY (millions)** |
| | **As of March 31, 2025** | **As of March 31, 2026** |
| **<u>LIABILITIES AND EQUITY</u>** | | |
| LIABILITIES |  |  |
| Non-current liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;Bonds and loans | 3966326 | 4369681 |
| &nbsp;&nbsp;&nbsp;Other financial liabilities | 550900 | 571248 |
| &nbsp;&nbsp;&nbsp;Net defined benefit liabilities | 135429 | 143683 |
| &nbsp;&nbsp;&nbsp;Provisions | 35177 | 37550 |
| &nbsp;&nbsp;&nbsp;Other non-current liabilities | 82859 | 99818 |
| &nbsp;&nbsp;&nbsp;Deferred tax liabilities | 35153 | 26804 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total non-current liabilities | 4805844 | 5248784 |
| Current liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;Bonds and loans | 548939 | 512157 |
| &nbsp;&nbsp;&nbsp;Trade and other payables | 475541 | 491345 |
| &nbsp;&nbsp;&nbsp;Other financial liabilities | 219120 | 141220 |
| &nbsp;&nbsp;&nbsp;Income taxes payable | 133497 | 97880 |
| &nbsp;&nbsp;&nbsp;Provisions | 533140 | <u>998501</u> |
| &nbsp;&nbsp;&nbsp;Other current liabilities | 596283 | 590152 |
| &nbsp;&nbsp;&nbsp;Liabilities held for sale |  | 818 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total current liabilities | 2506521 | <u>2832074</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;Total liabilities | 7312365 | <u>8080858</u> |
| EQUITY |  |  |
| &nbsp;&nbsp;&nbsp;Share capital | 1694685 | 1695277 |
| &nbsp;&nbsp;&nbsp;Share premium | 1775713 | 1776352 |
| &nbsp;&nbsp;&nbsp;Treasury shares | (74815) | (49128) |
| &nbsp;&nbsp;&nbsp;Retained earnings | 1187586 | <u>712381</u> |
| &nbsp;&nbsp;&nbsp;Other components of equity | 2351915 | 3297407 |
| &nbsp;&nbsp;&nbsp;Other comprehensive income associated with assets held for sale |  | (2848) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Equity attributable to owners of the Company | 6935084 | <u>7429441</u> |
| &nbsp;&nbsp;&nbsp;Non-controlling interests | 895 | 1208 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total equity | 6935979 | <u>7430649</u> |
| Total liabilities and equity | 14248344 | <u>15511506</u> |

---

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

**(4) Consolidated Statements of Changes in Equity**

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| | **JPY (millions)** | **JPY (millions)** | **JPY (millions)** | **JPY (millions)** | **JPY (millions)** | **JPY (millions)** |
| | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** |
| | **Share<br>capital** | **Share<br>premium** | **Treasury<br>shares** | **Retained<br>earnings** | **Other components of equity** | **Other components of equity** |
| | **Share<br>capital** | **Share<br>premium** | **Treasury<br>shares** | **Retained<br>earnings** | **Exchange<br>differences<br>on translation<br>of foreign<br>operations** | **Changes in fair value of financial assets measured at fair value through other comprehensive income** |
| As of April 1, 2024 | 1676596 | 1747414 | (51259) | 1391203 | 2573407 | 15729 |
| <u>Net profit (loss) for the year</u> |  |  |  | 107928 |  |  |
| Other comprehensive income (loss) |  |  |  |  | (153429) | (12311) |
| Comprehensive income (loss) for the year |  |  |  | 107928 | (153429) | (12311) |
| Transactions with owners: |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of new shares | 18089 | 18089 |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition of treasury shares |  | (20) | (51905) |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Disposal of treasury shares |  | 0 | 0 |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Dividends |  |  |  | (303160) |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Transfers from other components of equity |  |  |  | (8385) |  | 1339 |
| &nbsp;&nbsp;&nbsp;&nbsp;Share-based compensation |  | 74707 |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Exercise of share-based awards |  | (64476) | 28348 |  |  |  |
| Total transactions with owners | 18089 | 28300 | (23557) | (311545) |  | 1339 |
| As of March 31, 2025 | 1694685 | 1775713 | (74815) | 1187586 | 2419978 | 4757 |

---

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | | |
| | **Other components of equity** | **Other components of equity** | **Other components of equity** | **Other components of equity** | | | | |
| | **Cash flow<br>hedges** | **Hedging<br>cost** | **Remeasurements of defined benefit pension plans** | **Total <br>other components of equity** | **Other<br>comprehensive<br>income related<br>to assets held<br>for sale** | **Total <br>equity attributable to owners of the Company** | **Non-<br>controlling<br>interests** | **Total<br>equity** |
| As of April 1, 2024 | (63896) | (15930) |  | 2509310 |  | 7273264 | 741 | 7274005 |
| <u>Net profit (loss) for the year</u> |  |  |  |  |  | 107928 | 215 | 108143 |
| Other comprehensive income (loss) | (956) | 7963 | (7046) | (165780) |  | (165780) | (61) | (165841) |
| Comprehensive income (loss) for the year | (956) | 7963 | (7046) | (165780) |  | (57852) | 154 | (57698) |
| Transactions with owners: |  |  |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of new shares |  |  |  |  |  | 36178 |  | 36178 |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition of treasury shares |  |  |  |  |  | (51925) |  | (51925) |
| &nbsp;&nbsp;&nbsp;&nbsp;Disposal of treasury shares |  |  |  |  |  | 0 |  | 0 |
| &nbsp;&nbsp;&nbsp;&nbsp;Dividends |  |  |  |  |  | (303160) |  | (303160) |
| &nbsp;&nbsp;&nbsp;&nbsp;Transfers from other components of equity |  |  | 7046 | 8385 |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Share-based compensation |  |  |  |  |  | 74707 |  | 74707 |
| &nbsp;&nbsp;&nbsp;&nbsp;Exercise of share-based awards |  |  |  |  |  | (36129) |  | (36129) |
| Total transactions with owners |  |  | 7046 | 8385 |  | (280328) |  | (280328) |
| As of March 31, 2025 | (64852) | (7967) |  | 2351915 |  | 6935084 | 895 | 6935979 |

---

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| | **JPY (millions)** | **JPY (millions)** | **JPY (millions)** | **JPY (millions)** | **JPY (millions)** | **JPY (millions)** |
| | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** |
| | | | | | **Other components of equity** | **Other components of equity** |
| | **Share<br>capital** | **Share<br>premium** | **Treasury<br>shares** | **Retained<br>earnings** | **Exchange<br>differences<br>on translation<br>of foreign<br>operations** | **Changes in fair value of financial assets measured at fair value through other comprehensive income** |
| As of April 1, 2025 | 1694685 | 1775713 | (74815) | 1187586 | 2419978 | 4757 |
| <u>Net profit (loss) for the year</u> |  |  |  | <u>(152390)</u> |  |  |
| Other comprehensive income (loss) |  |  |  |  | 903306 | (4976) |
| Comprehensive income (loss) for the year |  |  |  | <u>(152390)</u> | 903306 | (4976) |
| Transactions with owners: |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of new shares | 593 | 593 |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition of treasury shares |  | (20) | (51618) |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Dividends |  |  |  | (312524) |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Transfers from other components of equity |  |  |  | (10292) |  | 12205 |
| &nbsp;&nbsp;&nbsp;&nbsp;Share-based compensation |  | 77371 |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Exercise of share-based awards |  | (77305) | 77305 |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Transfer to other comprehensive income associated with assets held for sale |  |  |  |  | 2848 |  |
| Total transactions with owners | 593 | 638 | 25687 | (322815) | 2848 | 12205 |
| As of March 31, 2026 | 1695277 | 1776352 | (49128) | <u>712381</u> | 3326132 | 11986 |

---

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | | |
| | **Other components of equity** | **Other components of equity** | **Other components of equity** | **Other components of equity** | | | | |
| | **Cash flow<br>hedges** | **Hedging<br>cost** | **Remeasurements of defined benefit pension plans** | **Total <br>other components of equity** | **Other<br>comprehensive<br>income related<br>to assets held<br>for sale** | **Total <br>equity attributable to owners of the Company** | **Non-<br>controlling<br>interests** | **Total<br>equity** |
| As of April 1, 2025 | (64852) | (7967) |  | 2351915 |  | 6935084 | 895 | 6935979 |
| <u>Net profit (loss) for the year</u> |  |  |  |  |  | <u>(152390)</u> | 264 | <u>(152125)</u> |
| Other comprehensive income (loss) | 28950 | 3159 | 1914 | 932352 |  | 932352 | 48 | 932401 |
| Comprehensive income (loss) for the year | 28950 | 3159 | 1914 | 932352 |  | <u>779963</u> | 313 | <u>780275</u> |
| Transactions with owners: |  |  |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of new shares |  |  |  |  |  | 1186 |  | 1186 |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition of treasury shares |  |  |  |  |  | (51638) |  | (51638) |
| &nbsp;&nbsp;&nbsp;&nbsp;Dividends |  |  |  |  |  | (312524) |  | (312524) |
| &nbsp;&nbsp;&nbsp;&nbsp;Transfers from other components of equity |  |  | (1914) | 10292 |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Share-based compensation |  |  |  |  |  | 77371 |  | 77371 |
| &nbsp;&nbsp;&nbsp;&nbsp;Exercise of share-based awards |  |  |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Transfer to other comprehensive income associated with assets held for sale |  |  |  | 2848 | (2848) |  |  |  |
| Total transactions with owners |  |  | (1914) | 13140 | (2848) | (285606) |  | (285606) |
| As of March 31, 2026 | (35903) | (4808) |  | 3297407 | (2848) | <u>7429441</u> | 1208 | <u>7430649</u> |

---

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

**(5) Consolidated Statements of Cash Flows**

---

| | | |
|:---|:---|:---|
| | **JPY (millions)** | **JPY (millions)** |
| | **For the year ended March 31,** | **For the year ended March 31,** |
| | **2025** | **2026** |
| Cash flows from operating activities: |  |  |
| &nbsp;&nbsp;&nbsp;<u>Net profit (loss) for the year</u> | 108143 | <u>(152125)</u> |
| &nbsp;&nbsp;&nbsp;Depreciation and amortization | 761396 | 721127 |
| &nbsp;&nbsp;&nbsp;Impairment losses | 106529 | 145716 |
| &nbsp;&nbsp;&nbsp;Equity-settled share-based compensation | 72867 | 72775 |
| &nbsp;&nbsp;&nbsp;Loss on sales and disposal of property, plant and equipment | 4495 | 3068 |
| &nbsp;&nbsp;&nbsp;Gain on divestment of business and subsidiaries | (10198) | (18265) |
| &nbsp;&nbsp;&nbsp;Change in fair value of financial assets and liabilities associated with contingent consideration arrangements, net | (602) | 1006 |
| &nbsp;&nbsp;&nbsp;Finance (income) and expenses, net | 163516 | 146395 |
| &nbsp;&nbsp;&nbsp;Share of loss of investments accounted for using the equity method | 3986 | 2177 |
| &nbsp;&nbsp;&nbsp;Income tax expenses | 66941 | <u>9770</u> |
| &nbsp;&nbsp;&nbsp;Changes in assets and liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Increase in trade and other receivables | (58959) | (70166) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Increase in inventories | (34973) | (61293) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Decrease in trade and other payables | (7118) | (3150) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Increase in provisions | 45166 | <u>416120</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Decrease in other financial liabilities | (3488) | (81606) |
| &nbsp;&nbsp;&nbsp;Settlement of forward exchange contracts, net | 5945 | 129727 |
| &nbsp;&nbsp;&nbsp;Other, net | (16052) | (47282) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Cash generated from operations | 1207595 | 1213993 |
| &nbsp;&nbsp;&nbsp;Income taxes paid | (170589) | (180405) |
| &nbsp;&nbsp;&nbsp;Tax refunds and interest on tax refunds received | 20176 | 7843 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net cash from operating activities | 1057182 | 1041431 |
| Cash flows from investing activities: |  |  |
| &nbsp;&nbsp;&nbsp;Interest received | 17660 | 17359 |
| &nbsp;&nbsp;&nbsp;Dividends received | 635 | 1298 |
| &nbsp;&nbsp;&nbsp;Acquisition of property, plant and equipment | (200795) | (176003) |
| &nbsp;&nbsp;&nbsp;Proceeds from sales of property, plant and equipment | 78 | 6454 |
| &nbsp;&nbsp;&nbsp;Acquisition of intangible assets | (147046) | (234930) |
| &nbsp;&nbsp;&nbsp;Acquisition of option to license | (31784) | (3726) |
| &nbsp;&nbsp;&nbsp;Acquisition of investments | (97536) | (15895) |
| &nbsp;&nbsp;&nbsp;Proceeds from sales and redemption of investments | 29442 | 7031 |
| &nbsp;&nbsp;&nbsp;Acquisition of shares in associates | (1004) | (623) |
| &nbsp;&nbsp;&nbsp;Proceeds from sales of shares in associates | 57691 | 880 |
| &nbsp;&nbsp;&nbsp;Proceeds from sales of business, net of cash and cash equivalents divested | 20556 | 33325 |
| &nbsp;&nbsp;&nbsp;Settlement of forward exchange contracts designated as net investment hedges, net | (13847) | (1536) |
| &nbsp;&nbsp;&nbsp;Other, net | (1111) | (2775) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net cash used in investing activities | (367060) | (369141) |

---

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

---

| | | |
|:---|:---|:---|
| | **JPY (millions)** | **JPY (millions)** |
| | **For the year ended March 31,** | **For the year ended March 31,** |
| | **2025** | **2026** |
| Cash flows from financing activities: |  |  |
| &nbsp;&nbsp;&nbsp;Net increase (decrease) in short-term loans and commercial papers | 27490 | (341780) |
| &nbsp;&nbsp;&nbsp;Proceeds from issuance of bonds and long-term loans | 1024460 | 586060 |
| &nbsp;&nbsp;&nbsp;Repayments of bonds and long-term loans | (1321090) | (200432) |
| &nbsp;&nbsp;&nbsp;Settlement of cross currency interest swaps related to bonds and loans | 46880 |  |
| &nbsp;&nbsp;&nbsp;Acquisition of treasury shares | (51860) | (51603) |
| &nbsp;&nbsp;&nbsp;Interest paid | (112984) | (121380) |
| &nbsp;&nbsp;&nbsp;Dividends paid | (302498) | (311901) |
| &nbsp;&nbsp;&nbsp;Repayments of lease liabilities | (45174) | (42772) |
| &nbsp;&nbsp;&nbsp;Other, net | (16647) | (13011) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net cash used in financing activities | (751425) | (496820) |
| Net increase (decrease) in cash and cash equivalents | (61303) | 175469 |
| Cash and cash equivalents at the beginning of the year | 457800 | 385113 |
| Effects of exchange rate changes on cash and cash equivalents | (11385) | 34472 |
| Cash and cash equivalents at the end of the year | 385113 | 595054 |

---

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

**(6) Notes to Consolidated Financial Statements**

(Going Concern Assumption)

Not applicable.

(Significant Items that Form the Basis of Preparing the Consolidated Financial Statements)

1. Basis of Preparation

(1) Compliance

Since Takeda satisfies all of the criteria of the "Specified Company" prescribed in item 1 of Article 1-2 of the Regulation On Terminology, Forms, and Preparation Methods of Consolidated Financial Statements (Ministry of Finance Order No.28, 1976 "Regulations for Consolidated Financial Statements"), the consolidated financial statements are prepared in accordance with International Financial Reporting Standards ("IFRS") pursuant to the provision of Article 312 of the Regulations for Consolidated Financial Statements.

(2) Basis of Measurement

The consolidated financial statements have been prepared on a historical cost basis, except for certain assets and liabilities recorded at fair value including equity investments, derivative financial instruments, and financial assets and liabilities associated with contingent consideration arrangements, and the application of hyperinflationary accounting at subsidiaries.

(3) Functional and Presentation Currency

The consolidated financial statements are presented in Japanese Yen ("JPY"), which is the functional currency of the Company. All financial information presented in JPY has been rounded to the nearest million JPY, except when otherwise indicated. In tables with rounded figures, sums may not add up due to rounding.

(4) Changes in Presentation

(Consolidated Statements of Financial Position)

"Income taxes payable", which had been presented separately under "Non-current liabilities" in the fiscal year ended March 31, 2025, has been included in "Other non-current liabilities" from the fiscal year ended March 31, 2026 due to immateriality. To reflect this change in presentation, the Consolidated Statements of Financial Position as of March 31, 2025 have been reclassified on a consistent basis.

As a result, the amounts previously reported as "Income taxes payable" within non-current liabilities of JPY 317 million and "Other non-current liabilities" of JPY 82,542 million in the Consolidated Statements of Financial Position as of March 31, 2025 have been reclassified and presented as "Other non-current liabilities" totaling JPY 82,859 million.

(Consolidated Statements of Cash Flows)

Cash flows arising from the settlement of forward exchange contracts, which had been included in "Other (net)" within cash flows from operating activities in the fiscal year ended March 31, 2025, have been presented separately as "Settlement of forward exchange contracts, net" from the fiscal year ended March 31, 2026 due to its increased materiality.

To reflect this change in presentation, the Consolidated Statements of Cash Flows in the fiscal year ended March 31, 2025 have been reclassified on a consistent basis.

As a result, in the Consolidated Statements of Cash Flows for the fiscal year ended March 31, 2025, an amount of JPY 10,107 million previously presented within "Other (net)" under "Cash flows from operating activities" has been reclassified and presented as JPY 5,945 million in "Settlement of forward exchange contracts, net" and JPY 16,052 million in "Other (net)."

This change represents a reclassification within cash flows from operating activities and has no impact on the total amount of net cash flows from operating activities.

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Fiscal Year

Ended March 31, 2026 (Consolidated)

2. Material Accounting Policies

During the year ended March 31, 2026, the material accounting standards applied in Takeda's consolidated financial statements were consistent with those applied in the prior year's consolidated financial statements.

(Operating Segment Information)

Takeda comprises a single operating segment and is engaged in the research, development, manufacturing, marketing and out-licensing of pharmaceutical products. This is consistent with how the financial information is viewed in allocating resources, measuring performance, and forecasting future periods by the CEO who is Takeda's Chief Operating Decision Maker.

(Earnings Per Share)

The basis for calculating basic and diluted earnings per share (attributable to owners of the Company) is as follows:

---

| | | |
|:---|:---|:---|
| | **For the year ended March 31,** | **For the year ended March 31,** |
| | **2025** | **2026** |
| Net profit <u>(loss)</u> for the year attributable to owners of the Company: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;<u>Net profit (loss) for the year attributable to owners of the Company JPY (millions)</u>  | 107928 | <u>(152390)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;<u>Net profit (loss) used for calculation of earnings per share JPY (millions)</u> | 107928 | <u>(152390)</u> |
| Weighted-average number of ordinary shares outstanding during the year (thousands of shares) [basic] | 1578873 | 1575062 |
| Dilutive effect (thousands of shares)<sup>\*</sup> | 26450 | <u>—</u> |
| Weighted-average number of ordinary shares outstanding during the year (thousands of shares) [diluted] | 1605323 | <u>1575062</u> |
| Earnings per share |  |  |
| &nbsp;&nbsp;&nbsp;Basic (JPY) | 68.36 | <u>(96.75)</u> |
| &nbsp;&nbsp;&nbsp;Diluted (JPY) | 67.23 | <u>(96.75)</u> |

---

<u>\* For the fiscal year ended March 31, 2026, the dilutive shares are not dilutive because loss per share attributable to owners of the Company would decrease upon the exercise of share options and stock incentive plans.</u>

(Significant Subsequent Events)

Not applicable.

## Exhibit 99.1

**Exhibit 99.1**

![image.jpg](image.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;**FINANCIAL APPENDIX**

---

| | |
|:---|:---|
| **Definition of Non-IFRS Measures** | |
| Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations | A-[1](#i37d427512a5d421ea9c9561c17bc6deb_133) |
| **Reconciliations and Other Financial Information** |  |
| FY2025 Reported Results with CER % Change | A-[4](#i37d427512a5d421ea9c9561c17bc6deb_22539988370809) |
| FY2025 Q4 (Jan-Mar) Reported Results with CER % Change | A-[5](#i37d427512a5d421ea9c9561c17bc6deb_22539988370820) |
| FY2025 Core Results with CER % Change | A-[6](#i37d427512a5d421ea9c9561c17bc6deb_22539988370831) |
| FY2025 Q4 (Jan-Mar) Core Results with CER % Change | A-[7](#i37d427512a5d421ea9c9561c17bc6deb_22539988370842) |
| FY2025 Reconciliation from Reported to Core | A-[8](#i37d427512a5d421ea9c9561c17bc6deb_22539988370861) |
| FY2025 Q4 (Jan-Mar) Reconciliation from Reported to Core | A-[9](#i37d427512a5d421ea9c9561c17bc6deb_22539988370874) |
| FY2024 Reconciliation from Reported to Core | A-[10](#i37d427512a5d421ea9c9561c17bc6deb_22539988370887) |
| FY2024 Q4 (Jan-Mar) Reconciliation from Reported to Core | A-[11](#i37d427512a5d421ea9c9561c17bc6deb_22539988370902) |
| FY2025 Adjusted Free Cash Flow | A-[12](#i37d427512a5d421ea9c9561c17bc6deb_151) |
| FY2025 Adjusted Net Debt to Adjusted EBITDA | A-[13](#i37d427512a5d421ea9c9561c17bc6deb_154) |
| FY2024 Adjusted Net Debt to Adjusted EBITDA | A-[14](#i37d427512a5d421ea9c9561c17bc6deb_14293651162420) |
| FY2025 Net Profit to Adjusted EBITDA Bridge | A-[15](#i37d427512a5d421ea9c9561c17bc6deb_160) |
| FY2025 CAPEX, Depreciation and Amortization and Impairment Losses | A-[16](#i37d427512a5d421ea9c9561c17bc6deb_169) |
| FY2025 Results vs. Forecast (Jan. 2026) | A-[17](#i37d427512a5d421ea9c9561c17bc6deb_3848290698515) |
| FY2026 Full Year Detailed Forecast | A-[18](#i37d427512a5d421ea9c9561c17bc6deb_1099511629391) |
| FY2026 Full Year Reconciliation from Reported Operating Profit to Core Operating Profit Forecast | A-[19](#i37d427512a5d421ea9c9561c17bc6deb_178) |
| FY2026 Full Year FX Rates Assumptions and Currency Sensitivity vs. Forecast | A-[20](#i37d427512a5d421ea9c9561c17bc6deb_166) |
| **Important Notice** |  |
| Important Notice, Forward-Looking Statements, Financial Information and Non-IFRS Measures, and Medical Information | A-[21](#i37d427512a5d421ea9c9561c17bc6deb_181) |

---

------

![image.jpg](image.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;**Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations**

**Core Financial Measures**

Takeda's Core Financial Measures, particularly **Core Revenue**, **Core Operating Profit**, **Core Net Profit for the Year attributable to owners of the Company** and **Core EPS**, exclude revenue from divestments, amortization and impairment losses on intangible assets associated with products (including in-process R&D) and other impacts unrelated to the underlying trends and business performance of Takeda's core operations, such as non-recurring items, purchase accounting effects and transaction related costs. **Core Revenue** represents revenue adjusted to exclude revenue items unrelated to the underlying trends and business performance of Takeda's core operations (primarily revenue or related adjustments associated with divestments and liquidations). **Core Operating Profit** represents operating profit adjusted to exclude other operating expenses and income, amortization and impairment losses on intangible assets associated with products (including in-process R&D) and non-cash items or items unrelated to the underlying trends and business performance of Takeda's core operations. **Core Net Profit for the Year attributable to owners of the Company** represents net profit for the year attributable to owners of the Company, adjusted to eliminate the impact of items excluded in the calculation of Core Operating Profit and other non-operating items (e.g. amongst other items, fair value adjustments and the imputed financial charge related to contingent consideration) that are unusual, non-recurring in nature or unrelated to the underlying trends and business performance of Takeda's ongoing operations and the tax effect of each of the adjustments. **Core EPS** is calculated by dividing Core Net Profit for the Year attributable to owners of the Company by the average outstanding shares (excluding treasury shares) of the reporting periods presented.

Takeda presents its Core Financial Measures because Takeda believes that these measures are useful to understanding its business without the effect of items that Takeda considers to be unrelated to the underlying trends and business performance of its core operations, including items (i) which may vary significantly from year-to-year or may not occur in each year or (ii) whose recognition Takeda believes is largely uncorrelated to trends in the underlying performance of our core business. Takeda believes that similar measures are frequently used by other companies in its industry and that providing these measures helps investors evaluate Takeda's performance against not only its performance in prior years but on a similar basis as its competitors. Takeda also presents Core Financial Measures because these measures are used by Takeda for budgetary planning and compensation purposes (i.e., certain targets for the purposes of Takeda's Short-Term Incentive and Long-Term Incentive compensation programs, including incentive compensation of the CEO and CFO, are set in relation to the results of Takeda's Core Financial Measures).

**Constant Exchange Rate ("CER") Change**

**CER Change** eliminates the effect of foreign exchange rates from year-over-year comparisons by translating financial results in accordance with IFRS or Core (non-IFRS) financial measures for the current period using corresponding exchange rates in the same period of the previous fiscal year, provided, however, that the results of operations of subsidiaries in countries experiencing hyperinflation, and for which IAS 29, Financial Reporting in Hyperinflationary Economies, is applied, are not adjusted for CER Change, and instead are calculated in accordance with IAS 29.

Takeda presents CER change because we believe that this measure is useful to investors to better understand the effect of exchange rates on our business and to understand how our results of operations might have changed from year to year without the effect of fluctuations in exchange rates. These are the primary ways in which our management uses these measures to evaluate our results of operations. We also believe that this is a useful measure for investors as similar performance measures are frequently used by securities analysts, investors and other interested parties in the evaluation of the results of operations of other companies in our industry (many of whom similarly present measures that adjust for the effect of exchange rates).

The usefulness of this presentation has significant limitations including but not limited to, that while CER change is calculated using the same exchange rates used to calculate financial results as presented under IFRS for the previous fiscal year, this does not necessarily mean that the transactions entered into during the relevant fiscal year could have been entered into or would have been recorded at the same exchange rates. Moreover, other companies in our industry using similarly titled measures may define and calculate those measures differently than we do and therefore such measures may not be directly comparable. Accordingly, CER change should not be considered in isolation and is not, and should not be viewed as, a substitute for change in financial results as prepared and presented in accordance with IFRS.

------

**Exhibit 99.1**

![image.jpg](image.jpg)

**Free Cash Flow and Adjusted Free Cash Flow**

Takeda defines **Free Cash Flow** as cash flows from operating activities less acquisition of property, plant and equipment ("PP&E"). Takeda defines **Adjusted Free Cash Flow** as cash flows from operating activities, subtracting payments for acquisition of PP&E, intangible assets, investments (excluding debt investments classified as Level 1 in the fair value hierarchy), shares in associates and businesses, net of cash and cash equivalents acquired and other transactional payments deemed related or similar in substance thereto as well as adding proceeds from sales of PP&E, sales and redemption of investments (excluding debt investments classified as Level 1 in the fair value hierarchy), sales of shares in associates and sales of businesses, net of cash and cash equivalents divested and further adjusting for the movement of any other cash that is not available to Takeda's immediate or general business use.

Takeda presents Free Cash Flow and Adjusted Free Cash Flow because Takeda believes that these measures are useful to investors as similar measures of liquidity are frequently used by securities analysts, investors and other interested parties in the evaluation of companies in our industry. Adjusted Free Cash Flow is also used by our management to evaluate our liquidity and our cash flows, particularly as they relate to our ability to meet our liquidity requirements and to support our capital allocation policies. Takeda also believes that Free Cash Flow and Adjusted Free Cash Flow are helpful to investors in understanding how our strategic acquisitions and divestitures of businesses contribute to our cash flows and liquidity.

The usefulness of Free Cash Flow and Adjusted Free Cash Flow to investors has significant limitations including, but not limited to, (i) they may not be comparable to similarly titled measures used by other companies, including those in our industry, (ii) they do not reflect the effect of our current and future contractual and other commitments requiring the use or allocation of capital and (iii) the addition of proceeds from sales and redemption of investments and the proceeds from sales of business, net of cash and cash equivalents divested do not represent cash received from our core ongoing operations. Free Cash Flow and Adjusted Free Cash Flow should not be considered in isolation and are not, and should not be viewed as, substitutes for cash flows from operating activities or any other measure of liquidity presented in accordance with IFRS. The most directly comparable measure under IFRS for Free Cash Flow and Adjusted Free Cash Flow is net cash from operating activities.

**EBITDA and Adjusted EBITDA**

Takeda defines **EBITDA** as consolidated net profit before income tax expenses, depreciation and amortization and net interest expense. Takeda defines **Adjusted EBITDA** as EBITDA further adjusted to exclude impairment losses, other operating income and expenses (excluding depreciation and amortization, as well as impairment losses), finance income and expenses (excluding net interest expense), our share of profit or loss of investments accounted for using the equity method, other non-cash items such as non-cash equity-based compensation expense, and other items that management believes are unrelated to our core operations, including EBITDA from divested products, purchase accounting effects and transaction related costs.

Takeda presents EBITDA and Adjusted EBITDA because Takeda believes that these measures are useful to investors as they are frequently used by securities analysts, investors and other interested parties in the evaluation of companies in our industry. Primarily, Adjusted EBITDA is used by Takeda for the purposes of monitoring its financial leverage. Takeda further believes that Adjusted EBITDA is helpful to investors in identifying trends in its business that could otherwise be obscured by certain items unrelated to ongoing operations because they are highly variable, difficult to predict, may substantially impact our results of operations and may limit the ability to evaluate our performance from one period to another on a consistent basis.

The usefulness of EBITDA and Adjusted EBITDA to investors has significant limitations including, but not limited to, (i) they may not be comparable to similarly titled measures used by other companies, including those in the pharmaceutical industry, (ii) they exclude financial information and events, such as the effects of an acquisition, or amortization of intangible assets, that some may consider important in evaluating Takeda's performance, value or prospects for the future, (iii) they exclude items or types of items that may continue to occur from period to period in the future and (iv) they may not include all items which investors may consider important to an understanding of our results of operations, or may not exclude all items which investors may not consider important for such understanding. EBITDA and Adjusted EBITDA should not be considered in isolation and are not, and should not be viewed as, substitutes for operating income, net profit for the year or any other measure of performance presented in accordance with IFRS. The most closely comparable measure presented in accordance with IFRS is net profit for the year.

------

**Exhibit 99.1**

![image.jpg](image.jpg)

**Net Debt and Adjusted Net Debt**

Takeda defines **Net Debt** as the book value of bonds and loans on consolidated statements of financial position adjusted only for cash and cash equivalents and **Adjusted Net Debt** first by calculating the sum of the current and non-current portions of bonds and loans as shown on our consolidated statement of financial position, which is then adjusted to reflect (i) the use of prior 12-month average exchange rates for non-JPY debt outstanding at the beginning of the current quarter and the use of relevant spot rates for new non-JPY debt incurred and existing non-JPY debt redeemed during the current quarter, which reflects the methodology our management uses to monitor our leverage, and (ii) the "equity credit" applied to Takeda's "hybrid" subordinated indebtedness by S&P Global Rating Japan in recognition of the equity-like features of those instruments pursuant to such agency's ratings methodology. To calculate Adjusted Net Debt, Takeda deducts from this figure cash and cash equivalents, excluding cash temporarily held by Takeda on behalf of third parties related to vaccine operations and to the trade receivables sales program, and debt investments classified as Level 1 in the fair value hierarchy being recorded as Other Financial Assets.

Takeda presents Net Debt and Adjusted Net Debt because Takeda believes that these measures are useful to investors in that our management uses it to monitor and evaluate our indebtedness, net of cash and cash equivalents and, in conjunction with Adjusted EBITDA, to monitor our financial leverage (for the avoidance of doubt, Adjusted Net Debt and the ratio of Adjusted Net Debt to Adjusted EBITDA are not intended to be indicators of Takeda's liquidity). Takeda also believes that similar measures of indebtedness are frequently used by securities analysts, investors and other interested parties in the evaluation of companies in our industry. Particularly following the acquisition of Shire, investors, analysts and, in particular, ratings agencies, have closely monitored Takeda's leverage, as represented by the ratio of its Adjusted Net Debt to Adjusted EBITDA. In light of the weight given by ratings agencies in particular to this ratio, Takeda believes that such information is useful to investors to help understand not only Takeda's financial leverage, but also how ratings agencies evaluate the level of financial leverage in evaluating Takeda's quality of credit. Accordingly, as described below, Takeda includes an adjustment to its Adjusted Net Debt to reflect the "equity credit" afforded to certain of its subordinated indebtedness by ratings agencies (such indebtedness does not qualify for treatment as equity under IFRS).

The usefulness of Adjusted Net Debt to investors has significant limitations including, but not limited to, (i) it may not be comparable to similarly titled measures used by other companies, including those in the pharmaceutical industry, (ii) it does not reflect the amounts of interest payments to be paid on Takeda's indebtedness, (iii) it does not reflect any restrictions on Takeda's ability to prepay or redeem any of our indebtedness, (iv) it does not reflect any fees, costs or other expenses that Takeda may incur in converting cash equivalents to cash, in converting cash from one currency into another or in moving cash within our consolidated group, (v) it applies to gross debt an adjustment for average foreign exchange rates which, although consistent with Takeda's financing agreements, does not reflect the actual rates at which Takeda would be able to convert one currency into another and (vi) it reflects an equity credit despite the fact that Takeda's subordinated bonds are not eligible for equity treatment under IFRS, although Takeda believes this adjustment to be reasonable and useful to investors. Adjusted Net Debt should not be considered in isolation and is not, and should not be viewed as, a substitute for bonds and loans or any other measure of indebtedness presented in accordance with IFRS. The most directly comparable measures under IFRS for Net Debt is bonds and loans.

**U.S. Dollar Convenience Translations**

In the Financial Appendix, certain amounts presented in Japanese yen have been translated to U.S. dollars solely for the convenience of the reader at an exchange rate of 1USD = 159.08 JPY, the Noon Buying Rate certified by the Federal Reserve Bank of New York on March 31, 2026. The rate and methodologies used for the convenience translations differ from the currency exchange rates and translation methodologies under IFRS used for the preparation of the condensed interim consolidated financial statements. The translation should not be construed as a representation that the Japanese yen amounts could be converted into U.S. dollars at this or any other rate.

------

![image.jpg](image.jpg)

![image2.jpg](image2.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Reported Results with CER % Change**

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| **(Billion JPY, except EPS)** | **FY2024** | **FY2025** | **AER** | **AER** | **AER** | **CER** | **CER** | **(Million USD,**<br>**except EPS)**<br>**FY2025**<br>**Convenience**<br>**USD Translation** |
| **(Billion JPY, except EPS)** | **FY2024** | **FY2025** | **JPY Change** | **% Change** | **% Change** | **% Change** | **% Change** | **(Million USD,**<br>**except EPS)**<br>**FY2025**<br>**Convenience**<br>**USD Translation** |
| Revenue | 4581.6 | 4505.7 | (75.8) | (1.7) | % | (2.7) | % | 28324 |
| &nbsp;&nbsp;Cost of sales | (1580.2) | (1571.6) | 8.6 | 0.5 | % | 1.9 | % | (9879) |
| Gross profit | 3001.3 | 2934.1 | (67.2) | (2.2) | % | (3.1) | % | 18444 |
| *Margin* | *65.5 %* | *65.1 %* |  | *(0.4)* | *pp* | *(0.3)* | *pp* | *65.1 %* |
| &nbsp;&nbsp;SG&A expenses | (1104.8) | (1084.2) | 20.6 | 1.9 | % | 2.5 | % | (6816) |
| &nbsp;&nbsp;R&D expenses | (730.2) | (675.9) | 54.3 | 7.4 | % | 7.0 | % | (4249) |
| &nbsp;&nbsp;Amortization of intangible assets associated with products | (548.2) | (504.3) | 43.9 | 8.0 | % | 7.7 | % | (3170) |
| &nbsp;&nbsp;Impairment losses on intangible assets associated with products<sup>\*</sup> | (95.0) | (129.3) | (34.2) | (36.0) | % | (33.3) | % | (813) |
| &nbsp;&nbsp;Other operating income | 26.2 | 24.7 | (1.5) | (5.6) | % | (4.4) | % | 156 |
| &nbsp;&nbsp;Other operating expenses | (206.7) | (559.0) | (352.2) | (170.4) | % | (168.9) | % | (3514) |
| Operating profit | 342.6 | 6.2 | (336.4) | (98.2) | % | ― | ― | 39 |
| *Margin* | *7.5 %* | *0.1 %* |  | *(7.3)* | *pp* | *(7.7)* | *pp* | *0.1 %* |
| &nbsp;&nbsp;Finance income | 46.5 | 211.2 | 164.6 | 353.7 | % | 353.8 | % | 1327 |
| &nbsp;&nbsp;Finance expenses | (210.1) | (357.6) | (147.5) | (70.2) | % | (72.5) | % | (2248) |
| &nbsp;&nbsp;Share of profit (loss) of investments accounted for using the equity method | (4.0) | (2.2) | 1.8 | 45.4 | % | 52.9 | % | (14) |
| Profit (loss) before tax | 175.1 | (142.4) | (317.4) | ― | ― | ― | ― | (895) |
| &nbsp;&nbsp;Income tax (expenses) benefit | (66.9) | (9.8) | 57.2 | 85.4 | % | 97.6 | % | (61) |
| Net profit (loss) for the year | 108.1 | (152.1) | (260.3) | ― | ― | ― | ― | (956) |
| &nbsp;&nbsp;Non-controlling interests | (0.2) | (0.3) | (0.0) | (22.9) | % | (30.8) | % | (2) |
| Net profit (loss) attributable to owners of the Company | 107.9 | (152.4) | (260.3) | ― | ― | ― | ― | (958) |
| Basic EPS (JPY or USD) | 68.36 | (96.75) | (165.11) | ― | ― | ― | ― | (0.61) |

---

\* Includes in-process R&D

The amount of change and percentage change based on Actual Exchange Rates are presented in "AER" (which is presented in accordance with IFRS) and percentage change based on Constant Exchange Rate (which is a non-IFRS measure) is presented in "CER". Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations*, for the definition of the "Constant Exchange Rate change".

% change is presented as positive when favorable to profits, and negative when unfavorable to profits.

------

![image.jpg](image.jpg)

![image2.jpg](image2.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q4 (Jan-Mar) Reported Results with CER % Change**

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| **(Billion JPY, except EPS)** | **FY2024 Q4**<br> **(Jan-Mar)** | **FY2025 Q4**<br> **(Jan-Mar)** | **AER** | **AER** | **AER** | **CER** | **CER** | **(Million USD,**<br>**except EPS)**<br>**FY2025 Q4 (Jan-Mar)**<br>**Convenience**<br>**USD Translation** |
| **(Billion JPY, except EPS)** | **FY2024 Q4**<br> **(Jan-Mar)** | **FY2025 Q4**<br> **(Jan-Mar)** | **JPY Change** | **% Change** | **% Change** | **% Change** | **% Change** | **(Million USD,**<br>**except EPS)**<br>**FY2025 Q4 (Jan-Mar)**<br>**Convenience**<br>**USD Translation** |
| Revenue | 1053.4 | 1094.5 | 41.1 | 3.9 | % | (2.2) | % | 6880 |
| &nbsp;&nbsp;Cost of sales | (382.1) | (405.7) | (23.6) | (6.2) | % | 0.4 | % | (2550) |
| Gross profit | 671.3 | 688.8 | 17.5 | 2.6 | % | (3.2) | % | 4330 |
| *Margin* | *63.7 %* | *62.9 %* |  | *(0.8)* | *pp* | *(0.7)* | *pp* | *62.9 %* |
| &nbsp;&nbsp;SG&A expenses | (295.9) | (292.0) | 3.9 | 1.3 | % | 6.0 | % | (1836) |
| &nbsp;&nbsp;R&D expenses | (216.0) | (195.3) | 20.7 | 9.6 | % | 11.5 | % | (1228) |
| &nbsp;&nbsp;Amortization of intangible assets associated with products | (136.5) | (107.4) | 29.2 | 21.4 | % | 24.1 | % | (675) |
| &nbsp;&nbsp;Impairment losses on intangible assets associated with products<sup>\*</sup> | (66.5) | (47.5) | 19.1 | 28.7 | % | 30.5 | % | (298) |
| &nbsp;&nbsp;Other operating income | 10.4 | 2.3 | (8.2) | (78.3) | % | (76.6) | % | 14 |
| &nbsp;&nbsp;Other operating expenses | (41.8) | (465.1) | (423.4) | (1013.9) | % | (1005.2) | % | (2924) |
| Operating profit (loss) | (74.9) | (416.2) | (341.2) | (455.4) | % | (471.6) | % | (2616) |
| *Margin* | *(7.1) %* | *(38.0) %* |  | *(30.9)* | *pp* | *(34.4)* | *pp* | *(38.0) %* |
| &nbsp;&nbsp;Finance income | 18.7 | 15.8 | (2.9) | (15.6) | % | (22.9) | % | 99 |
| &nbsp;&nbsp;Finance expenses | (50.3) | (54.3) | (4.0) | (7.9) | % | (5.7) | % | (341) |
| &nbsp;&nbsp;Share of profit (loss) of investments accounted for using the equity method | (0.8) | (0.4) | 0.4 | 54.2 | % | 50.4 | % | (2) |
| Profit (loss) before tax | (107.3) | (455.0) | (347.7) | (324.1) | % | (335.6) | % | (2860) |
| &nbsp;&nbsp;Income tax (expenses) benefit | 4.2 | 86.6 | 82.4 | 1961.8 | % | 2002.4 | % | 544 |
| Net profit (loss) for the period | (103.1) | (368.4) | (265.3) | (257.3) | % | (267.7) | % | (2316) |
| &nbsp;&nbsp;Non-controlling interests | (0.1) | (0.1) | (0.0) | (10.7) | % | (16.4) | % | (0) |
| Net profit (loss) attributable to owners of the Company | (103.2) | (368.5) | (265.3) | (257.2) | % | (267.6) | % | (2316) |
| Basic EPS (JPY or USD) | (65.25) | (233.25) | (168.00) | (257.5) | % | (267.9) | % | (1.47) |

---

\* Includes in-process R&D

The amount of change and percentage change based on Actual Exchange Rates are presented in "AER" (which is presented in accordance with IFRS) and percentage change based on Constant Exchange Rate (which is a non-IFRS measure) is presented in "CER". Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations*, for the definition of the "Constant Exchange Rate change".

% change is presented as positive when favorable to profits, and negative when unfavorable to profits.

------

![image.jpg](image.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Core Results with CER % Change**

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| **(Billion JPY, except EPS)** | **FY2024** | **FY2025** | **AER** | **AER** | **AER** | **CER** | **CER** | **(Million USD,**<br>**except EPS)**<br>**FY2025** <br>**Convenience**<br>**USD Translation** |
| **(Billion JPY, except EPS)** | **FY2024** | **FY2025** | **JPY Change** | **% Change** | **% Change** | **% Change** | **% Change** | **(Million USD,**<br>**except EPS)**<br>**FY2025** <br>**Convenience**<br>**USD Translation** |
| Revenue | 4579.8 | 4505.7 | (74.1) | (1.6) | % | (2.6) | % | 28324 |
| &nbsp;&nbsp;Cost of sales | (1581.8) | (1572.6) | 9.2 | 0.6 | % | 1.9 | % | (9886) |
| Gross profit | 2998.0 | 2933.1 | (64.9) | (2.2) | % | (3.0) | % | 18438 |
| *Margin* | *65.5 %* | *65.1 %* |  | *(0.4)* | *pp* | *(0.2)* | *pp* | *65.1 %* |
| &nbsp;&nbsp;SG&A expenses | (1105.0) | (1084.7) | 20.4 | 1.8 | % | 2.5 | % | (6818) |
| &nbsp;&nbsp;R&D expenses | (730.4) | (676.0) | 54.4 | 7.4 | % | 7.0 | % | (4249) |
| Operating profit | 1162.6 | 1172.5 | 9.8 | 0.8 | % | (0.9) | % | 7370 |
| *Margin* | *25.4 %* | *26.0 %* |  | *0.6* | *pp* | *0.4* | *pp* | *26.0 %* |
| &nbsp;&nbsp;Finance income | 34.3 | 211.1 | 176.8 | 515.3 | % | 515.3 | % | 1327 |
| &nbsp;&nbsp;Finance expenses | (175.0) | (344.3) | (169.3) | (96.7) | % | (99.5) | % | (2164) |
| &nbsp;&nbsp;Share of profit (loss) of investments accounted for using the equity method | 1.1 | (0.1) | (1.3) | ― | ― | (82.1) | % | (1) |
| Profit before tax | 1023.1 | 1039.2 | 16.1 | 1.6 | % | (0.9) | % | 6532 |
| &nbsp;&nbsp;Income tax (expenses) benefit | (247.3) | (224.8) | 22.5 | 9.1 | % | 12.8 | % | (1413) |
| Net profit for the year | 775.8 | 814.4 | 38.6 | 5.0 | % | 2.9 | % | 5119 |
| &nbsp;&nbsp;Non-controlling interests | (0.2) | (0.3) | (0.0) | (22.9) | % | (30.8) | % | (2) |
| Net profit attributable to owners of the Company | 775.6 | 814.1 | 38.5 | 5.0 | % | 2.9 | % | 5118 |
| Basic EPS (JPY or USD) | 491 | 517 | 26 | 5.2 | % | 3.1 | % | 3.25 |

---

The amount of change and percentage change based on Actual Exchange Rates are presented in "AER" (which is presented in accordance with IFRS) and percentage change based on Constant Exchange Rate (which is a non-IFRS measure) is presented in "CER". Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations*, for the definition of the "Constant Exchange Rate change".

% change is presented as positive when favorable to profits, and negative when unfavorable to profits.

------

![image.jpg](image.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q4 (Jan-Mar) Core Results with CER % Change**

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| **(Billion JPY, except EPS)** | **FY2024 Q4**<br> **(Jan-Mar)** | **FY2025 Q4**<br> **(Jan-Mar)** | **AER** | **AER** | **AER** | **CER** | **CER** | **(Million USD,**<br>**except EPS)**<br>**FY2025 Q4 (Jan-Mar)**<br>**Convenience**<br>**USD Translation** |
| **(Billion JPY, except EPS)** | **FY2024 Q4**<br> **(Jan-Mar)** | **FY2025 Q4**<br> **(Jan-Mar)** | **JPY Change** | **% Change** | **% Change** | **% Change** | **% Change** | **(Million USD,**<br>**except EPS)**<br>**FY2025 Q4 (Jan-Mar)**<br>**Convenience**<br>**USD Translation** |
| Revenue | 1051.7 | 1094.5 | 42.9 | 4.1 | % | (2.0) | % | 6880 |
| &nbsp;&nbsp;Cost of sales | (383.5) | (406.2) | (22.8) | (5.9) | % | 0.6 | % | (2554) |
| Gross profit | 668.2 | 688.3 | 20.1 | 3.0 | % | (2.8) | % | 4327 |
| *Margin* | *63.5 %* | *62.9 %* |  | *(0.7)* | *pp* | *(0.5)* | *pp* | *62.9 %* |
| &nbsp;&nbsp;SG&A expenses | (295.8) | (292.1) | 3.7 | 1.2 | % | 5.9 | % | (1836) |
| &nbsp;&nbsp;R&D expenses | (216.0) | (195.3) | 20.7 | 9.6 | % | 11.5 | % | (1228) |
| Operating profit | 156.4 | 200.9 | 44.5 | 28.5 | % | 15.1 | % | 1263 |
| *Margin* | *14.9 %* | *18.4 %* |  | *3.5* | *pp* | *2.6* | *pp* | *18.4 %* |
| &nbsp;&nbsp;Finance income | 12.9 | 15.8 | 2.9 | 22.9 | % | 12.3 | % | 99 |
| &nbsp;&nbsp;Finance expenses | (47.4) | (50.0) | (2.6) | (5.6) | % | (3.2) | % | (314) |
| &nbsp;&nbsp;Share of profit (loss) of investments accounted for using the equity method | (0.4) | (0.4) | 0.0 | 9.7 | % | 2.1 | % | (2) |
| Profit before tax | 121.4 | 166.3 | 44.9 | 36.9 | % | 19.5 | % | 1045 |
| &nbsp;&nbsp;Income tax (expenses) benefit | (44.7) | (25.7) | 19.0 | 42.6 | % | 50.4 | % | (161) |
| Net profit for the period | 76.8 | 140.6 | 63.9 | 83.2 | % | 60.1 | % | 884 |
| &nbsp;&nbsp;Non-controlling interests | (0.1) | (0.1) | (0.0) | (10.7) | % | (16.4) | % | (0) |
| Net profit attributable to owners of the Company | 76.7 | 140.6 | 63.9 | 83.2 | % | 60.2 | % | 884 |
| Basic EPS (JPY or USD) | 49 | 89 | 40 | 83.4 | % | 60.3 | % | 0.56 |

---

The amount of change and percentage change based on Actual Exchange Rates are presented in "AER" (which is presented in accordance with IFRS) and percentage change based on Constant Exchange Rate (which is a non-IFRS measure) is presented in "CER". Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations*, for the definition of the "Constant Exchange Rate change".

% change is presented as positive when favorable to profits, and negative when unfavorable to profits.

------

![image.jpg](image.jpg)

![image2.jpg](image2.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Reconciliation from Reported to Core**

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| **(Billion JPY, except EPS and number of shares)** | **Reported** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Core** |
| **(Billion JPY, except EPS and number of shares)** | **Reported** | Amortization of<br>intangible<br>assets | Impairment of<br>intangible<br>assets | Other<br>operating income/<br>expenses | Others | **Core** |
| Revenue | 4505.7 |  |  |  |  | 4505.7 |
| &nbsp;&nbsp;Cost of sales | (1571.6) |  |  |  | (1.0) | (1572.6) |
| Gross profit | 2934.1 |  |  |  | (1.0) | 2933.1 |
| &nbsp;&nbsp;SG&A expenses | (1084.2) |  |  |  | (0.5) | (1084.7) |
| &nbsp;&nbsp;R&D expenses | (675.9) |  |  |  | (0.0) | (676.0) |
| &nbsp;&nbsp;Amortization of intangible assets associated with products | (504.3) | 504.3 |  |  |  |  |
| &nbsp;&nbsp;Impairment losses on intangible assets associated with products<sup>\*</sup> | (129.3) |  | 129.3 |  |  |  |
| &nbsp;&nbsp;Other operating income | 24.7 |  |  | (24.7) |  |  |
| &nbsp;&nbsp;Other operating expenses | (559.0) |  |  | 559.0 |  |  |
| Operating profit | 6.2 | 504.3 | 129.3 | 534.2 | (1.5) | 1172.5 |
| *Margin* | 0.1% |  |  |  |  | 26.0% |
| &nbsp;&nbsp;Finance income and (expenses), net | (146.4) |  |  |  | 13.2 | (133.2) |
| &nbsp;&nbsp;Share of profit (loss) of investments accounted for using the equity method | (2.2) |  |  |  | 2.0 | (0.1) |
| Profit (loss) before tax | (142.4) | 504.3 | 129.3 | 534.2 | 13.7 | 1039.2 |
| &nbsp;&nbsp;Income tax (expenses) benefit | (9.8) | (107.2) | (17.5) | (85.4) | (4.9) | (224.8) |
| &nbsp;&nbsp;Non-controlling interests | (0.3) |  |  |  |  | (0.3) |
| Net profit (loss) attributable to owners of the Company | (152.4) | 397.1 | 111.7 | 448.8 | 8.9 | 814.1 |
| Basic EPS (JPY) | (97) |  |  |  |  | 517 |
| Number of shares (millions) | 1575 |  |  |  |  | 1575 |

---

\* Includes in-process R&D.

------

![image.jpg](image.jpg)

![image2.jpg](image2.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q4 (Jan-Mar) Reconciliation from Reported to Core**

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| **(Billion JPY, except EPS and number of shares)** | **Reported** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Core** |
| **(Billion JPY, except EPS and number of shares)** | **Reported** | Amortization of<br>intangible<br>assets | Impairment of<br>intangible<br>assets | Other<br>operating income/<br>expenses | Others | **Core** |
| Revenue | 1094.5 |  |  |  |  | 1094.5 |
| &nbsp;&nbsp;Cost of sales | (405.7) |  |  |  | (0.5) | (406.2) |
| Gross profit | 688.8 |  |  |  | (0.5) | 688.3 |
| &nbsp;&nbsp;SG&A expenses | (292.0) |  |  |  | (0.2) | (292.1) |
| &nbsp;&nbsp;R&D expenses | (195.3) |  |  |  | 0.0 | (195.3) |
| &nbsp;&nbsp;Amortization of intangible assets associated with products | (107.4) | 107.4 |  |  |  |  |
| &nbsp;&nbsp;Impairment losses on intangible assets associated with products<sup>\*</sup> | (47.5) |  | 47.5 |  |  |  |
| &nbsp;&nbsp;Other operating income | 2.3 |  |  | (2.3) |  |  |
| &nbsp;&nbsp;Other operating expenses | (465.1) |  |  | 465.1 |  |  |
| Operating profit (loss) | (416.2) | 107.4 | 47.5 | 462.8 | (0.7) | 200.9 |
| *Margin* | (38.0)% |  |  |  |  | 18.4% |
| &nbsp;&nbsp;Finance income and (expenses), net | (38.5) |  |  |  | 4.3 | (34.2) |
| &nbsp;&nbsp;Share of profit (loss) of investments accounted for using the equity method | (0.4) |  |  |  |  | (0.4) |
| Profit (loss) before tax | (455.0) | 107.4 | 47.5 | 462.8 | 3.6 | 166.3 |
| &nbsp;&nbsp;Income tax (expenses) benefit | 86.6 | (27.3) | (11.4) | (72.6) | (1.1) | (25.7) |
| &nbsp;&nbsp;Non-controlling interests | (0.1) |  |  |  |  | (0.1) |
| Net profit (loss) attributable to owners of the Company | (368.5) | 80.1 | 36.1 | 390.3 | 2.6 | 140.6 |
| Basic EPS (JPY) | (233) |  |  |  |  | 89 |
| Number of shares (millions) | 1580 |  |  |  |  | 1580 |

---

\* Includes in-process R&D.

------

![image.jpg](image.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;**FY2024 Reconciliation from Reported to Core**

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| **(Billion JPY, except EPS and number of shares)** | **Reported** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Core** |
| **(Billion JPY, except EPS and number of shares)** | **Reported** | Amortization of<br>intangible<br>assets | Impairment of<br>intangible<br>assets | Teva JV related adjustment | Other<br>operating income/<br>expenses | Others | **Core** |
| Revenue | 4581.6 |  |  | (1.7) |  |  | 4579.8 |
| &nbsp;&nbsp;Cost of sales | (1580.2) |  |  |  |  | (1.6) | (1581.8) |
| Gross profit | 3001.3 |  |  | (1.7) |  | (1.6) | 2998.0 |
| &nbsp;&nbsp;SG&A expenses | (1104.8) |  |  |  |  | (0.3) | (1105.0) |
| &nbsp;&nbsp;R&D expenses | (730.2) |  |  |  |  | (0.1) | (730.4) |
| &nbsp;&nbsp;Amortization of intangible assets associated with products | (548.2) | 548.2 |  |  |  |  |  |
| &nbsp;&nbsp;Impairment losses on intangible assets associated with products<sup>\*</sup> | (95.0) |  | 95.0 |  |  |  |  |
| &nbsp;&nbsp;Other operating income | 26.2 |  |  | (3.8) | (22.4) |  |  |
| &nbsp;&nbsp;Other operating expenses | (206.7) |  |  |  | 206.7 |  |  |
| Operating profit | 342.6 | 548.2 | 95.0 | (5.6) | 184.3 | (2.0) | 1162.6 |
| *Margin* | 7.5% |  |  |  |  |  | 25.4% |
| &nbsp;&nbsp;Finance income and (expenses), net | (163.5) |  |  | 18.9 |  | 4.0 | (140.7) |
| &nbsp;&nbsp;Share of profit (loss) of investments accounted for using the equity method | (4.0) |  |  |  |  | 5.1 | 1.1 |
| Profit before tax | 175.1 | 548.2 | 95.0 | 13.3 | 184.3 | 7.1 | 1023.1 |
| &nbsp;&nbsp;Income tax (expenses) benefit | (66.9) | (114.9) | (23.4) | (4.1) | (45.1) | 7.3 | (247.3) |
| &nbsp;&nbsp;Non-controlling interests | (0.2) |  |  |  |  |  | (0.2) |
| Net profit attributable to owners of the Company | 107.9 | 433.3 | 71.6 | 9.3 | 139.2 | 14.3 | 775.6 |
| Basic EPS (JPY) | 68 |  |  |  |  |  | 491 |
| Number of shares (millions) | 1579 |  |  |  |  |  | 1579 |

---

\* Includes in-process R&D.

------

![image.jpg](image.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;**FY2024 Q4 (Jan-Mar) Reconciliation from Reported to Core**

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| **(Billion JPY, except EPS and number of shares)** | **Reported** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Core** |
| **(Billion JPY, except EPS and number of shares)** | **Reported** | Amortization of<br>intangible<br>assets | Impairment of<br>intangible<br>assets | Teva JV related adjustment | Other<br>operating income/<br>expenses | Others | **Core** |
| Revenue | 1053.4 |  |  | (1.7) |  |  | 1051.7 |
| &nbsp;&nbsp;Cost of sales | (382.1) |  |  |  |  | (1.4) | (383.5) |
| Gross profit | 671.3 |  |  | (1.7) |  | (1.4) | 668.2 |
| &nbsp;&nbsp;SG&A expenses | (295.9) |  |  |  |  | 0.0 | (295.8) |
| &nbsp;&nbsp;R&D expenses | (216.0) |  |  |  |  | (0.0) | (216.0) |
| &nbsp;&nbsp;Amortization of intangible assets associated with products | (136.5) | 136.5 |  |  |  |  |  |
| &nbsp;&nbsp;Impairment losses on intangible assets associated with products<sup>\*</sup> | (66.5) |  | 66.5 |  |  |  |  |
| &nbsp;&nbsp;Other operating income | 10.4 |  |  | (3.8) | (6.6) |  |  |
| &nbsp;&nbsp;Other operating expenses | (41.8) |  |  |  | 41.8 |  |  |
| Operating profit | (74.9) | 136.5 | 66.5 | (5.6) | 35.1 | (1.4) | 156.4 |
| *Margin* | (7.1)% |  |  |  |  |  | 14.9% |
| &nbsp;&nbsp;Finance income and (expenses), net | (31.6) |  |  | (0.5) |  | (2.5) | (34.5) |
| &nbsp;&nbsp;Share of profit (loss) of investments accounted for using the equity method | (0.8) |  |  |  |  | 0.4 | (0.4) |
| Profit before tax | (107.3) | 136.5 | 66.5 | (6.0) | 35.1 | (3.4) | 121.4 |
| &nbsp;&nbsp;Income tax (expenses) benefit | 4.2 | (28.8) | (15.2) | 1.8 | (8.6) | 1.9 | (44.7) |
| &nbsp;&nbsp;Non-controlling interests | (0.1) |  |  |  |  |  | (0.1) |
| Net profit attributable to owners of the Company | (103.2) | 107.8 | 51.3 | (4.2) | 26.5 | (1.5) | 76.7 |
| Basic EPS (JPY) | (65) |  |  |  |  |  | 49 |
| Number of shares (millions) | 1581 |  |  |  |  |  | 1581 |

---

\* Includes in-process R&D.

------

![image.jpg](image.jpg)

![image2.jpg](image2.jpg)

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Adjusted Free Cash Flow** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Adjusted Free Cash Flow** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Adjusted Free Cash Flow** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Adjusted Free Cash Flow** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Adjusted Free Cash Flow** | |
| **(Billion JPY)** | **FY2024** | **FY2025** | **JPY Change** | **% Change** |<br>**(Million USD)<br>FY2025<br>Convenience USD Translation** |
| Net profit (loss) | 108.1 | (152.1) | (260.3) | (240.7)% | (956) |
| &nbsp;&nbsp;&nbsp;&nbsp;Depreciation, amortization and impairment losses | 867.9 | 866.8 | (1.1) |  | 5449 |
| &nbsp;&nbsp;&nbsp;&nbsp;Decrease (increase) in trade working capital | (101.0) | (134.6) | (33.6) |  | (846) |
| &nbsp;&nbsp;&nbsp;&nbsp;Income taxes paid | (170.6) | (180.4) | (9.8) |  | (1134) |
| &nbsp;&nbsp;&nbsp;&nbsp;Tax refunds and interest on tax refunds received | 20.2 | 7.8 | (12.3) |  | 49 |
| &nbsp;&nbsp;&nbsp;&nbsp; Settlement of forward exchange contracts, net | 5.9 | 129.7 | 123.8 |  | 815 |
| &nbsp;&nbsp;&nbsp;&nbsp;Other | 326.6 | 504.2 | 177.5 |  | 3169 |
| Net cash from operating activities (Operating Cash Flow) | 1057.2 | 1041.4 | (15.8) | (1.5)% | 6547 |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition of PP&E | (200.8) | (176.0) | 24.8 |  | (1106) |
| Free Cash Flow<sup>\*1</sup> | 856.4 | 865.4 | 9.0 | 1.1% | 5440 |
| &nbsp;&nbsp;&nbsp;&nbsp;Adjustment for cash temporarily held by Takeda on behalf of third parties<sup>\*2</sup> | 2.1 | 26.6 | 24.5 |  | 167 |
| &nbsp;&nbsp;&nbsp;&nbsp;Proceeds from sales of PP&E | 0.1 | 6.5 | 6.4 |  | 41 |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition of intangible assets<sup>\*3</sup> | (147.0) | (234.9) | (87.9) |  | (1477) |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition of option to license | (31.8) | (3.7) | 28.1 |  | (23) |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition of investments<sup>\*4</sup> | (17.4) | (15.9) | 1.5 |  | (100) |
| &nbsp;&nbsp;&nbsp;&nbsp;Proceeds from sales and redemption of investments | 29.4 | 7.0 | (22.4) |  | 44 |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition of shares in associates | (1.0) | (0.6) | 0.4 |  | (4) |
| &nbsp;&nbsp;&nbsp;&nbsp;Proceeds from sales of shares in associates | 57.7 | 0.9 | (56.8) |  | 6 |
| &nbsp;&nbsp;&nbsp;&nbsp;Proceeds from sales of business, net of cash and cash equivalents divested | 20.6 | 33.3 | 12.8 |  | 209 |
| Adjusted Free Cash Flow<sup>\*1</sup> | 769.0 | 684.5 | (84.4) | (11.0)% | 4303 |

---

\*1 Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations* for the definitions of Free Cash Flow and Adjusted Free Cash Flow.

\*2 Adjustment for cash temporarily held by Takeda on behalf of third parties refers to changes in cash balances that are temporarily held by Takeda on behalf of third parties related to vaccine operations and the trade receivables sales program, which are not available to Takeda's immediate or general business use.

\*3 Proceeds from sales of intangible assets are included in cash flow from operating activities, except certain immaterial transactions.

\*4 Acquisition of JPY 80.1 billion debt investments classified as Level 1 in the fair value hierarchy is excluded for the fiscal year ended March 31, 2025.

------

![image.jpg](image.jpg)

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Adjusted Net Debt to Adjusted EBITDA** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Adjusted Net Debt to Adjusted EBITDA** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Adjusted Net Debt to Adjusted EBITDA** | | | | |
| **ADJUSTED NET DEBT/ADJUSTED EBITDA RATIO** | | **NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS** | | | | |
| **(Billion JPY)** | **FY2025** | **(Billion JPY)** | **FY2024** | **FY2025** | **JPY Change** | **% Change** |
| &nbsp;&nbsp;Book value of bonds and loans on consolidated statement of financial position | (4881.8) | Net cash from operating activities (Operating Cash Flow) | 1057.2 | 1041.4 | (15.8) | (1.5)% |
| &nbsp;&nbsp;Book value of bonds and loans on consolidated statement of financial position | (4881.8) | &nbsp;&nbsp;Acquisition of PP&E | (200.8) | (176.0) |  |  |
| &nbsp;&nbsp;Cash & cash equivalents | 595.1 | &nbsp;&nbsp;Proceeds from sales of PP&E | 0.1 | 6.5 |  |  |
| Net Debt<sup>\*1</sup> | (4286.8) | &nbsp;&nbsp;Acquisition of intangible assets | (147.0) | (234.9) |  |  |
| &nbsp;&nbsp;Application of equity credit<sup>\*2</sup>  | 250.0 | &nbsp;&nbsp;Acquisition of option to license | (31.8) | (3.7) |  |  |
| &nbsp;&nbsp;FX adjustment<sup>\*3</sup> | 213.2 | &nbsp;&nbsp;Acquisition of investments | (97.5) | (15.9) |  |  |
| &nbsp;&nbsp;Cash temporarily held by Takeda on behalf of third parties<sup>\*4</sup> | (79.2) | &nbsp;&nbsp;Proceeds from sales and redemption of investments | 29.4 | 7.0 |  |  |
| &nbsp;&nbsp;Level 1 debt investments<sup>\*4</sup> | 85.1 | &nbsp;&nbsp;Acquisition of shares in associates | (1.0) | (0.6) |  |  |
| Adjusted Net Debt<sup>\*1</sup> | (3817.6) | &nbsp;&nbsp;Proceeds from sales of shares in associates | 57.7 | 0.9 |  |  |
|  |  | &nbsp;&nbsp;Proceeds from sales of business, net of cash and cash equivalents divested | 20.6 | 33.3 |  |  |
| Adjusted EBITDA | 1457.2 | &nbsp;&nbsp;Settlement of forward exchange contracts designated as net investment hedges, net | (13.8) | (1.5) |  |  |
|  |  | &nbsp;&nbsp;Net increase (decrease) in short-term loans and commercial papers | 27.5 | (341.8) |  |  |
| Adjusted Net Debt/Adjusted EBITDA ratio | 2.6x | &nbsp;&nbsp;Proceeds from long-term loans | 90.0 | 60.0 |  |  |
|  |  | &nbsp;&nbsp;Repayment of long-term loans | (587.2) | (85.1) |  |  |
| &nbsp;&nbsp;Book value of bonds and loans on consolidated statement of financial position | (4881.8) | &nbsp;&nbsp;Proceeds from issuance of bonds | 934.5 | 526.1 |  |  |
| &nbsp;&nbsp;Book value of bonds and loans on consolidated statement of financial position | (4881.8) | &nbsp;&nbsp;Repayment of bonds | (733.8) | (115.3) |  |  |
| &nbsp;&nbsp;Application of equity credit<sup>\*2</sup>  | 250.0 | &nbsp;&nbsp;Settlement of cross currency interest rate swaps related to bonds and loans | 46.9 |  |  |  |
| &nbsp;&nbsp;FX adjustment<sup>\*3</sup> | 213.2 | &nbsp;&nbsp;Acquisition of treasury shares | (51.9) | (51.6) |  |  |
| Adjusted Gross Debt | (4418.7) | &nbsp;&nbsp;Interest paid | (113.0) | (121.4) |  |  |
|  |  | &nbsp;&nbsp;Dividends paid | (302.5) | (311.9) |  |  |
|  |  | &nbsp;&nbsp;Others | (44.6) | (39.9) |  |  |
|  |  | Net increase (decrease) in cash and cash equivalents | (61.3) | 175.5 | 236.8 | (386.2)% |

---

\*1 Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations* for the definitions of Net Debt and Adjusted Net Debt.

\*2 Application of equity credit includes JPY 250.0 billion reduction in debt due to a 50% equity credit applied to JPY 500.0 billion principal amount of our hybrid (subordinated) bonds and loans by S&P Global Rating Japan, given that those instruments qualify for certain equity credit for leverage purposes.

\*3 FX adjustment refers to change from month-end rate to average rate used for non-JPY debt calculation outstanding at the beginning of the current quarter to match with adjusted EBITDA (which is calculated based on average rates). New non-JPY debt incurred and existing non-JPY debt redeemed during the current quarter are translated to JPY at relevant spot rates as of the relevant date.

\*4 Adjustments related to cash temporarily held by Takeda on behalf of third parties related to the trade receivables sales program, which is not available to Takeda's immediate or general business use, and debt investments classified as Level 1 in the fair value hierarchy being recorded as Other Financial Assets.

------

![image.jpg](image.jpg)

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;&nbsp;&nbsp;**FY2024 Adjusted Net Debt to Adjusted EBITDA** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2024 Adjusted Net Debt to Adjusted EBITDA** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2024 Adjusted Net Debt to Adjusted EBITDA** | | | | |
| **ADJUSTED NET DEBT/ADJUSTED EBITDA RATIO** | | **NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS** | | | | |
| **(Billion JPY)** | **FY2024** | **(Billion JPY)** | **FY2023** | **FY2024** | **JPY Change** | **% Change** |
| &nbsp;&nbsp;Book value of bonds and loans on consolidated statement of financial position | (4515.3) | Net cash from operating activities (Operating Cash Flow) | 716.3 | 1057.2 | 340.8 | 47.6% |
| &nbsp;&nbsp;Book value of bonds and loans on consolidated statement of financial position | (4515.3) | &nbsp;&nbsp;Acquisition of PP&E | (175.4) | (200.8) |  |  |
| &nbsp;&nbsp;Cash & cash equivalents | 385.1 | &nbsp;&nbsp;Proceeds from sales of PP&E | 8.6 | 0.1 |  |  |
| Net Debt<sup>\*1</sup> | (4130.2) | &nbsp;&nbsp;Acquisition of intangible assets | (305.3) | (147.0) |  |  |
| &nbsp;&nbsp;Application of equity credit<sup>\*2</sup> | 250.0 | &nbsp;&nbsp;Acquisition of option to license |  | (31.8) |  |  |
| &nbsp;&nbsp;FX adjustment<sup>\*3</sup> | (68.9) | &nbsp;&nbsp;Acquisition of investments | (6.8) | (97.5) |  |  |
| &nbsp;&nbsp;Cash temporarily held by Takeda on behalf of third parties<sup>\*4</sup> | (105.8) | &nbsp;&nbsp;Proceeds from sales and redemption of investments | 8.0 | 29.4 |  |  |
| &nbsp;&nbsp;Level 1 debt investments<sup>\*4</sup> | 79.3 | &nbsp;&nbsp;Acquisition of shares in associates |  | (1.0) |  |  |
| Adjusted Net Debt<sup>\*1</sup> | (3975.5) | &nbsp;&nbsp;Proceeds from sales of shares in associates |  | 57.7 |  |  |
|  |  | &nbsp;&nbsp;Proceeds from sales of business, net of cash and cash equivalents divested | 20.0 | 20.6 |  |  |
| Adjusted EBITDA | 1441.0 | &nbsp;&nbsp;Settlement of forward exchange contracts designated as net investment hedges, net | (33.3) | (13.8) |  |  |
|  |  | &nbsp;&nbsp;Net increase (decrease) in short-term loans and commercial papers | 277.0 | 27.5 |  |  |
| Adjusted Net Debt/Adjusted EBITDA ratio | 2.8x | &nbsp;&nbsp;Proceeds from long-term loans | 100.0 | 90.0 |  |  |
|  |  | &nbsp;&nbsp;Repayment of long-term loans | (100.4) | (587.2) |  |  |
| &nbsp;&nbsp;Book value of bonds and loans on consolidated statement of financial position | (4515.3) | &nbsp;&nbsp;Proceeds from issuance of bonds |  | 934.5 |  |  |
| &nbsp;&nbsp;Book value of bonds and loans on consolidated statement of financial position | (4515.3) | &nbsp;&nbsp;Repayment of bonds | (220.5) | (733.8) |  |  |
| &nbsp;&nbsp;Application of equity credit<sup>\*2</sup> | 250.0 | &nbsp;&nbsp;Settlement of cross currency interest rate swaps related to bonds and loans | 60.1 | 46.9 |  |  |
| &nbsp;&nbsp;FX adjustment<sup>\*3</sup> | (68.9) | &nbsp;&nbsp;Acquisition of treasury shares | (2.3) | (51.9) |  |  |
| Adjusted Gross Debt | (4334.2) | &nbsp;&nbsp;Interest paid | (100.4) | (113.0) |  |  |
|  |  | &nbsp;&nbsp;Dividends paid | (287.2) | (302.5) |  |  |
|  |  | &nbsp;&nbsp;Others | (60.3) | (44.6) |  |  |
|  |  | Net increase (decrease) in cash and cash equivalents | (101.9) | (61.3) | 40.6 | 39.9% |

---

\*1 Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations* for the definitions of Net Debt and Adjusted Net Debt.

\*2 Application of equity credit includes JPY 250.0 billion reduction in debt due to a 50% equity credit applied to JPY 500.0 billion principal amount of our hybrid (subordinated) bonds and loans by S&P Global Rating Japan, given that those instruments qualify for certain equity credit for leverage purposes.

\*3 FX adjustment refers to change from month-end rate to average rate used for non-JPY debt calculation outstanding at the beginning of the current quarter to match with adjusted EBITDA (which is calculated based on average rates). New non-JPY debt incurred and existing non-JPY debt redeemed during the current quarter are translated to JPY at relevant spot rates as of the relevant date.

\*4 Adjustments related to cash temporarily held by Takeda on behalf of third parties related to vaccine operations and to the trade receivables sales program, which is not available to Takeda's immediate or general business use, and debt investments classified as Level 1 in the fair value hierarchy being recorded as Other Financial Assets.

------

![image.jpg](image.jpg)

![image2.jpg](image2.jpg)

---

| | | | | |
|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Net Profit to Adjusted EBITDA Bridge** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Net Profit to Adjusted EBITDA Bridge** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Net Profit to Adjusted EBITDA Bridge** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Net Profit to Adjusted EBITDA Bridge** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Net Profit to Adjusted EBITDA Bridge** |
| **(Billion JPY)** | **FY2024** | **FY2025** | **JPY Change** | **% Change** |
| Net profit (loss) | 108.1 | (152.1) | (260.3) | (240.7)% |
| &nbsp;&nbsp;Income tax expenses (benefit) | 66.9 | 9.8 |  |  |
| &nbsp;&nbsp;Depreciation and amortization | 761.4 | 721.1 |  |  |
| &nbsp;&nbsp;Interest expense, net | 117.7 | 131.2 |  |  |
| EBITDA | 1054.2 | 710.0 | (344.1) | (32.6)% |
| &nbsp;&nbsp;Impairment losses | 106.5 | 145.7 |  |  |
| &nbsp;&nbsp;Other operating expenses (income), net, excluding depreciation and amortization, and impairment losses | 163.2 | 516.7 |  |  |
| &nbsp;&nbsp;Finance expenses (income), net, excluding interest expense, net | 45.8 | 15.1 |  |  |
| &nbsp;&nbsp;Share of loss (profit) of investments accounted for using the equity method | 4.0 | 2.2 |  |  |
| &nbsp;&nbsp;Other adjustments: | 67.4 | 69.6 |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Teva JV related adjustment | (1.7) |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Other costs<sup>\*1</sup> | 69.2 | 69.6 |  |  |
| &nbsp;&nbsp;EBITDA from divested products<sup>\*2</sup> | (0.2) | (2.1) |  |  |
| Adjusted EBITDA | 1441.0 | 1457.2 | 16.2 | 1.1% |

---

\*1 Includes adjustments for non-cash items such as non-cash equity-based compensation expense, and other items that management believes are unrelated to our core operations, including purchase accounting effects and transaction related costs.

\*2 Represents adjustments for EBITDA from divested products which are removed as part of Adjusted EBITDA.

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![image.jpg](image.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;**FY2025 CAPEX, Depreciation and Amortization and Impairment Losses**

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| **(Billion JPY)** | **FY2024** | **FY2025** | **JPY Change** | **% Change** | **2026 Forecast** |
| Capital expenditures<sup>\*1</sup> | 347.8 | 410.9 | 63.1 | 18.1% | 330.0 - 380.0 |
| &nbsp;&nbsp;Tangible assets | 200.8 | 176.0 | (24.8) | (12.3)% |  |
| &nbsp;&nbsp;Intangible assets | 147.0 | 234.9 | 87.9 | 59.8% |  |
| Depreciation and amortization | 761.4 | 721.1 | (40.3) | (5.3)% | 648.5 |
| &nbsp;&nbsp;Depreciation of tangible assets<sup>\*2</sup> (A) | 173.8 | 174.5 | 0.7 | 0.4% |  |
| &nbsp;&nbsp;Amortization of intangible assets (B) | 587.6 | 546.6 | (41.0) | (7.0)% |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Of which Amortization on intangible assets associated with products (C) | 548.2 | 504.3 | (43.9) | (8.0)% | 413.5 |
| &nbsp;&nbsp;&nbsp;&nbsp;Of which Amortization excluding intangible assets <br>&nbsp;&nbsp;&nbsp;&nbsp;associated with products (D) | 39.4 | 42.4 | 3.0 | 7.5% |  |
| Depreciation and amortization (excluding<br> intangible assets associated with products) (A)+(D) | 213.2 | 216.8 | 3.6 | 1.7% | 235.0 |
| Impairment losses | 106.5 | 145.7 | 39.2 | 36.8% |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Impairment losses on intangible assets associated with products<sup>\*3</sup> | 95.0 | 129.3 | 34.2 | 36.0% | 100.0 |
| Amortization and impairment losses on intangible assets associated with products | 643.2 | 633.5 | (9.7) | (1.5)% | 513.5 |
| \*1 Cash flow base |  |  |  |  |  |
| \*2 Includes depreciation of investment properties | \*2 Includes depreciation of investment properties | \*2 Includes depreciation of investment properties | \*2 Includes depreciation of investment properties | \*2 Includes depreciation of investment properties | \*2 Includes depreciation of investment properties |
| \*3 Includes in-process R&D |  |  |  |  |  |

---

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![image.jpg](image.jpg)

![image2.jpg](image2.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Results vs. Forecast (Jan. 2026)**

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| **(BN JPY)** | **(BN JPY)** | **FY2025 Forecast<br>(January 29, 2026)** | **FY2025<br>Actual** | **vs. Forecast** | **vs. Forecast** | **Variances** |
| **(BN JPY)** | **(BN JPY)** | **FY2025 Forecast<br>(January 29, 2026)** | **FY2025<br>Actual** | **vs. Forecast** | **vs. Forecast** | **Variances** |
| **REPORTED** | Revenue | 4530.0 | 4505.7 | (24.3) | (0.5)% | Lower-than-expected sales of products including ENTYVIO and PDT products, partially offset by favorable foreign exchange impacts |
| **REPORTED** | &nbsp;&nbsp;&nbsp;Cost of sales | (1595.0) | (1571.6) | 23.4 | 1.5% |  |
| **REPORTED** | Gross Profit | 2935.0 | 2934.1 | (0.9) | (0.0)% | Improvement in gross profit margin due to changes in product mix |
| **REPORTED** | &nbsp;&nbsp;&nbsp;SG&A expenses | (1098.0) | (1084.2) | 13.8 | 1.3% | Additional cost savings from the enterprise-wide efficiency program |
| **REPORTED** | &nbsp;&nbsp;&nbsp;R&D expenses | (687.0) | (675.9) | 11.1 | 1.6% | Additional cost savings from the enterprise-wide efficiency program |
| **REPORTED** | &nbsp;&nbsp;&nbsp;Amortization of intangible assets associated with products | (507.0) | (504.3) | 2.7 | 0.5% |  |
| **REPORTED** | &nbsp;&nbsp;Impairment losses on intangible assets associated with products<sup>\*1</sup> | (110.0) | (129.3) | (19.3) | (17.5)% | Primarily due to impairment losses on ALUNBRIG (JPY 31.9 B) |
| **REPORTED** | &nbsp;&nbsp;&nbsp;Other operating income | 27.0 | 24.7 | (2.3) | (8.3)% |  |
| **REPORTED** | &nbsp;&nbsp;&nbsp;Other operating expenses | (150.0) | (559.0) | (409.0) | (272.7)% | Provision for AMITIZA Antitrust Litigation: FY25 JPY 403.5 B.<br>Increase in restructuring expenses (FY25 forecast: JPY 56.0 B vs. FY25 actual: JPY 70.8 B) due to the transformation program |
| **REPORTED** | Operating profit | 410.0 | 6.2 | (403.8) | (98.5)% |  |
| **REPORTED** | &nbsp;&nbsp;&nbsp;Finance income (expenses), net | (163.0) | (146.4) | 16.6 | 10.2% | Due to higher-than-expected gains on foreign exchange derivatives, as well as lower-than-expected interest expense reflecting the phasing of refinancing |
| **REPORTED** | Profit (loss) before tax | 245.0 | (142.4) | (387.4) | - |  |
| **REPORTED** | Net profit (loss) attributable to owners of the Company | 154.0 | (152.4) | (306.4) | - | Tax benefit on provision for AMITIZA Antitrust Litigation: FY25 JPY 58.6 B. |
| **REPORTED** | Basic EPS (yen) | 98 | (97) | (195) | - |  |
|  | Core Revenue<sup>\*2</sup> | 4530.0 | 4505.7 | (24.3) | (0.5)% | Lower-than-expected sales of products including ENTYVIO and PDT products, partially offset by favorable foreign exchange impacts |
|  | Core Operating Profit<sup>\*2</sup> | 1150.0 | 1172.5 | 22.5 | 2.0% | Despite lower-than-expected revenue, cost savings under the enterprise-wide efficiency program more than offset the impact |
|  | Core EPS (yen)<sup>\*2</sup> | 486 | 517 | 30 | 6.3% | Increase in Core OP, combined with improvement in the effective tax rate driven by the reassessment of deferred tax asset recoverability |
|  | Adjusted Free Cash Flow<sup>\*2</sup> | 650.0 to 750.0 | 684.5 |  |  |  |
|  | CAPEX (cash flow base) | (400.0) to (450.0) | (410.9) |  |  |  |
|  | Depreciation and amortization (excl. intangible assets associated with products) | (220.0) | (216.8) | 3.2 | 1.4% |  |
|  | Cash tax rate on Adjusted EBITDA (excl. divestitures)<sup>\*2</sup> | Low-teen% | ~12% |  |  |  |
|  | USD/JPY | 150 | 150 | (0) | (0.2)% |  |
|  | EUR/JPY | 174 | 174 | 0 | 0.0% |  |

---

\*1 Includes in-process R&D.<br>\*2 Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations*, for the definition of Non-IFRS Measures.

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![image.jpg](image.jpg)

![image2.jpg](image2.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;**FY2026 Full Year Detailed Forecast**

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| **(BN JPY)** | **(BN JPY)** | **FY2025<br>Actual** | **FY2026 Forecast<br>(May 13, 2026)** | **JPY Change** | **% Change** | **Variances** |
| **(BN JPY)** | **(BN JPY)** | **FY2025<br>Actual** | **FY2026 Forecast<br>(May 13, 2026)** | **JPY Change** | **% Change** | **Variances** |
| **REPORTED** | Revenue | 4505.7 | 4640.0 | 134.3 | 3.0% | FX tailwinds and contributions from newly launched products more than offset the negative impact from LOE products |
| **REPORTED** | &nbsp;&nbsp;&nbsp;Cost of sales | (1571.6) | (1625.0) | (53.4) | (3.4)% |  |
| **REPORTED** | Gross Profit | 2934.1 | 3015.0 | 80.9 | 2.8% |  |
| **REPORTED** | &nbsp;&nbsp;&nbsp;SG&A expenses | (1084.2) | (1093.0) | (8.8) | (0.8)% | Cost savings from the transformation program largely offset launch costs for new products and adverse FX impacts |
| **REPORTED** | &nbsp;&nbsp;&nbsp;R&D expenses | (675.9) | (762.0) | (86.1) | (12.7)% | Increased expenses related to late-stage pipeline programs and adverse FX impacts partially offset by transformation program savings |
| **REPORTED** | &nbsp;&nbsp;&nbsp;Amortization of intangible assets associated with products | (504.3) | (413.5) | 90.8 | 18.0% | Amortization of VYVANSE concluded in January 2026. |
| **REPORTED** | &nbsp;&nbsp;Impairment losses on intangible assets associated with products<sup>\*1</sup> | (129.3) | (100.0) | 29.3 | 22.6% |  |
| **REPORTED** | &nbsp;&nbsp;&nbsp;Other operating income | 24.7 | 2.5 | (22.2) | (89.9)% | Lower gains from divestitures |
| **REPORTED** | &nbsp;&nbsp;&nbsp;Other operating expenses | (559.0) | (229.0) | 330.0 | 59.0% | Provision for AMITIZA Antitrust Litigation: FY25 JPY 403.5 B.<br>Higher restructuring expenses (FY25 actual: JPY 70.8 B vs. FY26 forecast: JPY 170.0 B) |
| **REPORTED** | Operating profit | 6.2 | 420.0 | 413.8 | - |  |
| **REPORTED** | &nbsp;&nbsp;&nbsp;Finance income (expenses), net | (146.4) | (170.0) | (23.6) | (16.1)% | Increase/decrease of gains and losses on foreign currency exchange and derivative financial assets related to foreign currency exchange |
| **REPORTED** | Profit (loss) before tax | (142.4) | 252.0 | 394.4 | - |  |
| **REPORTED** | Net profit (loss) attributable to owners of the Company | (152.4) | 166.0 | 318.4 | - | Tax benefit on provision for AMITIZA Antitrust Litigation: FY25 JPY 58.6 B. |
| **REPORTED** | Basic EPS (yen) | (97) | 104 | 201 | - |  |
|  | Core Revenue<sup>\*2</sup> | 4505.7 | 4640.0 | 134.3 | 3.0% | FX tailwinds and contributions from newly launched products more than offset the negative impact from LOE products |
|  | Core Operating Profit<sup>\*2</sup> | 1172.5 | 1160.0 | (12.5) | (1.1)% | Revenue growth expected, but higher OPEX |
|  | Core EPS (yen)<sup>\*2</sup> | 517 | 472 | (45) | (8.7)% | Lower effective tax rate in FY25 driven by the reassessment of deferred tax asset recoverability |
|  | Adjusted Free Cash Flow<sup>\*2</sup> | 684.5 | 650.0 to 750.0 |  |  | Broadly in line with FY25. Core OP is expected to be flat year-on-year, with higher FY26 restructuring expenses offset by lower CAPEX. |
|  | CAPEX (cash flow base) | (410.9) | (330.0) to (380.0) |  |  | FY25 actuals include USD 1.2 B upfront payment under the strategic global partnership agreement with Innovent Biologics. Up to USD 400 million in payments to Protagonist Therapeutics, associated with its exercise of the opt out right from the 50/50 U.S. profit and loss share structure, are included in FY26. |
|  | Depreciation and amortization (excl. intangible assets associated with products) | (216.8) | (235.0) | (18.2) | (8.4)% |  |
|  | Cash tax rate on Adjusted EBITDA (excl. divestitures)<sup>\*2</sup> | ~12% | Low 10s% |  |  |  |
|  | USD/JPY | 150 | 156 | 6 | 3.9% |  |
|  | EUR/JPY | 174 | 182 | 8 | 4.8% |  |

---

\*1 Includes in-process R&D.<br>\*2 Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations*, for the definition of Non-IFRS Measures and FY2026 Full Year Reconciliation from Reported Operating Profit to Core Operating Profit Forecast.

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![image.jpg](image.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;**FY2026 Full Year Reconciliation from Reported Operating Profit to Core Operating Profit Forecast**

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| **(Billion JPY)** | **Reported** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Core** |
| **(Billion JPY)** | **Reported** | Amortization of<br>intangible<br>assets | Impairment of<br>intangible<br>assets | Other operating income (expenses) | **Core** |
| Revenue | 4640.0 |  |  |  | 4640.0 |
| &nbsp;&nbsp;Cost of sales | (1625.0) |  |  |  | (3480.0) |
| Gross Profit | 3015.0 |  |  |  | (3480.0) |
| &nbsp;&nbsp;SG&A expenses | (1093.0) |  |  |  | (3480.0) |
| &nbsp;&nbsp;R&D expenses | (762.0) |  |  |  | (3480.0) |
| &nbsp;&nbsp;Amortization of intangible assets<br>associated with products | (413.5) | 413.5 |  |  |  |
| &nbsp;&nbsp;Impairment losses on intangible assets associated with products<sup>\*1</sup> | (100.0) |  | 100.0 |  |  |
| &nbsp;&nbsp;Other operating income | 2.5 |  |  | (2.5) |  |
| &nbsp;&nbsp;Other operating expenses | (229.0) |  |  | 229.0 |  |
| Operating profit | 420.0 | 413.5 | 100.0 | 226.5 | 1160.0 |

---

\*1 Includes in-process R&D

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![image.jpg](image.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;**FY2026 Full Year FX Rates Assumptions and Currency Sensitivity vs. Forecast**

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| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| **Average Exchange Rates vs. JPY** | **Average Exchange Rates vs. JPY** | **Average Exchange Rates vs. JPY** | **Average Exchange Rates vs. JPY** | **Impact of depreciation of yen from April 2026 to March 2027 (100 million JPY)** | **Impact of depreciation of yen from April 2026 to March 2027 (100 million JPY)** | **Impact of depreciation of yen from April 2026 to March 2027 (100 million JPY)** | **Impact of depreciation of yen from April 2026 to March 2027 (100 million JPY)** | **Impact of depreciation of yen from April 2026 to March 2027 (100 million JPY)** |
| | **FY2024<br>Actual<br>(Apr-Mar)** | **FY2025<br>Actual<br>(Apr-Mar)** | **FY2026 Full Year<br>Assumption<br>(Apr-Mar)** | | **Revenue<br>(IFRS)** | **Operating<br>Profit<br>(IFRS)** | **Net Profit<br>(IFRS)** | **Core<br>Operating<br>Profit<br>(non-IFRS)** |
| **USD** | 152 | 150 | 156 | 1% depreciation | 206.1 | 4.2 | (3.4) | 37.3 |
| **USD** | 152 | 150 | 156 | 1 yen depreciation | 132.1 | 2.7 | (2.2) | 23.9 |
| **EUR** | 163 | 174 | 182 | 1% depreciation | 69.2 | (28.4) | (20.6) | (17.7) |
| **EUR** | 163 | 174 | 182 | 1 yen depreciation | 38.0 | (15.6) | (11.3) | (9.7) |
| **RUB** | 1.6 | 1.9 | 2.0 | 1% depreciation | 4.5 | 2.7 | 1.8 | 2.9 |
| **CNY** | 21.1 | 21.1 | 22.4 | 1% depreciation | 19.9 | 12.2 | 8.2 | 12.2 |
| **BRL** | 27.4 | 27.6 | 29.5 | 1% depreciation | 14.2 | 11.5 | 7.7 | 11.6 |

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**Important Notice**

For the purposes of this notice, "report" means this document, any oral presentation, any question and answer session and any written or oral material discussed or distributed by Takeda Pharmaceutical Company Limited ("Takeda") regarding this report. This report (including any oral briefing and any question-and-answer in connection with it) is not intended to, and does not constitute, represent or form part of any offer, invitation or solicitation of any offer to purchase, otherwise acquire, subscribe for, exchange, sell or otherwise dispose of, any securities or the solicitation of any vote or approval in any jurisdiction. No shares or other securities are being offered to the public by means of this report. No offering of securities shall be made in the United States except pursuant to registration under the U.S. Securities Act of 1933, as amended, or an exemption therefrom. This report is being given (together with any further information which may be provided to the recipient) on the condition that it is for use by the recipient for information purposes only (and not for the evaluation of any investment, acquisition, disposal or any other transaction). Any failure to comply with these restrictions may constitute a violation of applicable securities laws.

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**Forward-Looking Statements**

This report and any materials distributed in connection with this report may contain forward-looking statements, beliefs or opinions regarding Takeda's future business, future position and results of operations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking statements often include words such as "targets", "plans", "believes", "hopes", "continues", "expects", "aims", "intends", "ensures", "will", "may", "should", "would", "could", "anticipates", "estimates", "projects", "forecasts", "outlook" or similar expressions or the negative thereof. These forward-looking statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those expressed or implied by the forward-looking statements: the economic circumstances surrounding Takeda's global business, including general economic conditions in Japan and the United States and with respect to international trade relations; competitive pressures and developments; changes to applicable laws and regulations, including drug pricing, tax, tariff and other trade-related rules; challenges inherent in new product development, including uncertainty of clinical success and decisions of regulatory authorities and the timing thereof; uncertainty of commercial success for new and existing products; manufacturing difficulties or delays; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the impact of health crises, like the novel coronavirus pandemic; the success of our environmental sustainability efforts, in enabling us to reduce our greenhouse gas emissions or meet our other environmental goals; the extent to which our efforts to increase efficiency, productivity or cost-savings, such as the integration of digital technologies, including artificial intelligence, in our business or other initiatives to restructure our operations will lead to the expected benefits; and other factors identified in Takeda's most recent Annual Report on Form 20-F and Takeda's other reports filed with the U.S. Securities and Exchange Commission, available on Takeda's website at: https://www.takeda.com/investors/sec-filings-and-security-reports/ or at www.sec.gov. Takeda does not undertake to update any of the forward-looking statements contained in this report or any other forward-looking statements it may make, except as required by law or stock exchange rule. Past performance is not an indicator of future results and the results or statements of Takeda in this report may not be indicative of, and are not an estimate, forecast, guarantee or projection of Takeda's future results.

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**Financial Information and Non-IFRS Measures**

Takeda's financial statements are prepared in accordance with International Financial Reporting Standards ("IFRS").

This report and materials distributed in connection with this report include certain financial measures not presented in accordance with IFRS, such as Core Revenue, Core Operating Profit, Core Net Profit for the year attributable to owners of the Company, Core EPS, Constant Exchange Rate ("CER") change, Net Debt, Adjusted Net Debt, EBITDA, Adjusted EBITDA, Free Cash Flow and Adjusted Free Cash Flow. Takeda's management evaluates results and makes operating and investment decisions using both IFRS and non-IFRS measures included in this presentation. These non-IFRS measures exclude certain income, cost and cash flow items which are included in, or are calculated differently from, the most closely comparable measures presented in accordance with IFRS. Takeda's non-IFRS measures are not prepared in accordance with IFRS and such non-IFRS measures should be considered a supplement to, and not a substitute for, measures prepared in accordance with IFRS (which we sometimes refer to as "reported" measures). Investors are encouraged to review the definitions and reconciliations of non-IFRS measures to their most directly comparable IFRS measures.

The usefulness of Core Financial Measures to investors has significant limitations including, but not limited to, (i) they are not necessarily identical to similarly titled measures used by other companies, including those in the pharmaceutical industry, (ii) they exclude financial information and events, such as the effects of non-cash expenses such as legal provisions, dispositions or amortization of intangible assets, that some may consider important in evaluating Takeda's performance, value or prospects for the future, (iii) they exclude items or types of items that may continue to occur from period to period in the future (however, it is Takeda's policy not to adjust out normal, recurring cash operating expenses necessary to operate our business) and (iv) they may not include all items which investors may consider important to an understanding of our results of operations, or exclude all items which investors may not consider to be so.

**Medical Information**

This report contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs including the ones under development.

## Exhibit 99.2

![](revision001.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Additional Provision for Legal Proceedings and Revision of the Earnings Report (Kessan Tanshin) for the Fiscal Year Ended March 31, 2026 (IFRS, Consolidated) OSAKA, Japan, June 5, 2026 – Takeda (TSE:4502/NYSE:TAK) ("Takeda") today revised the "Earnings Report (Kessan Tanshin) for the Fiscal Year Ended March 31, 2026 (IFRS, Consolidated)" disclosed on May 13, 2026, which reflected the impact of the subsequent event. Takeda also resubmitted the revised XBRL information. 1. Details of the Subsequent Event On May 18, 2026 (U.S. Eastern Time), a jury in the U.S. District Court for the District of Massachusetts returned a verdict against Takeda in the AMITIZA® (lubiprostone) antitrust litigation. For the details, please refer to the press release, "Takeda Provides an Update regarding Jury Verdict in AMITIZA® (lubiprostone) Antitrust Litigation in the U.S. and Related Revision to FY2025 Financial Results", announced on May 19, 2026. The jury verdict was a subsequent event that related to a condition that existed as of March 31, 2026. Accordingly, Takeda revised the consolidated financial results for the fiscal year, which ended on March 31, 2026 (FY2025). The amount of any liability that may ultimately be imposed on Takeda has not yet been finalized. Takeda intends to pursue post-trial motions and an appeal and will seek a stay of execution of the judgment during the pendency of the appeal. 2. Revision Takeda recorded an additional provision for legal proceedings of JPY 402.5 billion and recognized related tax benefits of JPY 58.4 billion in the consolidated financial statements for FY2025. This revision has no impact on Takeda's Core financial results for FY2025. The year-end dividend for FY2025 remains unchanged at JPY 100 per share. Furthermore, there are no changes to the FY2026 financial forecast or Management Guidance, including the forecast for adjusted free cash flow. The annual dividend forecast for FY2026 also remains unchanged at JPY 204 per share. Takeda does not expect its FY2026 financial forecast or Management Guidance to be materially impacted by the proceedings of AMITIZA antitrust litigation during FY2026. We will continue to assess the progress and financial impacts, depending on the district court judgment expected through the second half of the calendar year 2026 and proceedings thereafter, and provide an update as necessary. Please refer to the underlined items of the attached document where revisions were made. ###

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![](revision002.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Reference: Amount Updated in FY2025 Consolidated Statements of Profit or Loss and Consolidated Statements of Financial Position

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