# EDGAR Filing Document

**Accession Number:** 0001757499
**File Stem:** 0001641172-25-022787
**Filing Date:** 2025-8
**Character Count:** 2314
**Document Hash:** 20c9016dc34ce771fa1149dbb20b8a50
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001641172-25-022787.hdr.sgml**: 20250909

**ACCESSION NUMBER**: 0001641172-25-022787

**CONFORMED SUBMISSION TYPE**: CORRESP

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20250808

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Shuttle Pharmaceuticals Holdings, Inc.
- **CENTRAL INDEX KEY:** 0001757499
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** CORRESP

**BUSINESS ADDRESS:**
- **STREET 1:** 401 PROFESSIONAL DRIVE
- **STREET 2:** SUITE 260
- **CITY:** GAITHERSBURG
- **STATE:** MD
- **ZIP:** 20879
- **BUSINESS PHONE:** (240) 403-4212

**MAIL ADDRESS:**
- **STREET 1:** 401 PROFESSIONAL DRIVE
- **STREET 2:** SUITE 260
- **CITY:** GAITHERSBURG
- **STATE:** MD
- **ZIP:** 20879

**SHUTTLE PHARMACEUTICALS HOLDINGS, INC.**

**401 Professional Drive, Suite 260**

**Gaithersburg, MD 20879**

August 8, 2025

**<u>VIA EDGAR</u>**

U.S. Securities and Exchange Commission

Division of Corporation Finance

Office of Trade & Services

100 F Street, N.E.

Washington, D.C. 20549

Attention: Mr. Tyler Howes

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| | |
|:---|:---|
| **Re:** | **Shuttle Pharmaceuticals Holdings, Inc.** |
|  | **Registration Statement on Form S-1** |
|  | **Filed August 5, 2025** |
|  | **File No. 333-289231** |

---

Dear Mr. Howes,

Pursuant to Rule 461 under the Securities Act of 1933, as amended (the "Act"), Shuttle Pharmaceuticals Holdings, Inc. (the "Company") respectfully requests that the Securities and Exchange Commission accelerate the effectiveness of the above-referenced Registration Statement on Form S-1 (the "Registration Statement") and declare such Registration Statement effective at 4:30 p.m., Eastern Standard Time, on Monday, August 11, 2025, or as soon thereafter as practicable.

It would be appreciated if, as soon as the Registration Statement is declared effective, you would so inform Jeff Cahlon, Esq. of Sichenzia Ross Ference Carmel at 212-930-9700.

\* \* \* \*

Very Truly Yours,

---

| |
|:---|
| **Shuttle Pharmaceuticals Holdings, Inc.** |
| */s/ Christopher Cooper* |
| Christopher Cooper |
| Chief Executive Officer |

---

cc: Jeff Cahlon, Esq.