# EDGAR Filing Document

**Accession Number:** 0001867096
**File Stem:** 0001867096-26-000012
**Filing Date:** 2026-3
**Character Count:** 31310
**Document Hash:** 2fbd13352225f94fbbbdeff3b770112d
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001867096-26-000012.hdr.sgml**: 20260302

**ACCESSION NUMBER**: 0001867096-26-000012

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 14

**CONFORMED PERIOD OF REPORT**: 20260302

**ITEM INFORMATION**: Results of Operations and Financial Condition

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20260302

**DATE AS OF CHANGE**: 20260302

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Xeris Biopharma Holdings, Inc.
- **CENTRAL INDEX KEY:** 0001867096
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 871082097
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-40880
- **FILM NUMBER:** 26703444

**BUSINESS ADDRESS:**
- **STREET 1:** 1375 WEST FULTON STREET, SUITE 1300
- **CITY:** CHICAGO
- **STATE:** IL
- **ZIP:** 60607
- **BUSINESS PHONE:** 844-445-5704

**MAIL ADDRESS:**
- **STREET 1:** 1375 WEST FULTON STREET, SUITE 1300
- **CITY:** CHICAGO
- **STATE:** IL
- **ZIP:** 60607

?xml version='1.0' encoding='ASCII'? xers-20260302

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**FORM 8-K**

**CURRENT REPORT**

**Pursuant to Section 13 or 15(d)**

 **of the Securities Exchange Act of 1934**

Date of Report (Date of earliest event reported): March 2, 2026

**XERIS BIOPHARMA HOLDINGS, INC.** 

(Exact name of registrant as specified in its charter)

---

| | | |
|:---|:---|:---|
| **Delaware** | **001-40880** | **87-1082097** |
| (State or other jurisdiction of<br>incorporation) | (Commission<br>File Number) | (I.R.S. Employer<br>Identification No.) |

---

**1375 West Fulton Street, Suite 1300**

**Chicago, Illinois 60607**

(Address of principal executive offices, including zip code)

**(844) 445-5704**

(Registrant's telephone number, including area code)

**(Not applicable)**

(Former name or former address, if changed since last report)

---

| | | | |
|:---|:---|:---|:---|
| Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions: | Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions: | Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions: | Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions: |
| ☐ | Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) | Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) | Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) |
| ☐ | Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) | Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) | Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) |
| ☐ | Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) | Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) | Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |
| ☐ | Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) | Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) | Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |
| Securities registered pursuant to Section 12(b) of the Act: | Securities registered pursuant to Section 12(b) of the Act: | Securities registered pursuant to Section 12(b) of the Act: | Securities registered pursuant to Section 12(b) of the Act: |
| Title of each class | Title of each class | Trading Symbol(s) | Name of each exchange on which registered |
| Common Stock, par value $0.0001 per share | Common Stock, par value $0.0001 per share | XERS | The Nasdaq Global Select Market |
| Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter). | Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter). | Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter). | Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter). |

---

Emerging growth company ◻

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

------

**Item 2.02 Results of Operations and Financial Condition.**

On March 2, 2026, Xeris Biopharma Holdings, Inc. (the "Company") issued a press release containing information about the Company's results of operations and business highlights for the three and twelve months ended December 31, 2025. A copy of this press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K.

The information in this Item 2.02, including Exhibit 99.1, is being furnished and shall not be deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liabilities of that section and shall not be deemed incorporated by reference into any registration statement or other document filed pursuant to the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such filing.

**Item 9.01&nbsp;&nbsp;&nbsp;&nbsp;Financial Statements and Exhibits.**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**(d) Exhibits**

---

| | |
|:---|:---|
| **Exhibit <u>Number</u>** | **<u>Description</u>** |
| 99.1 | <u>[Press release, dated](exh991q42025earningsrelease.htm)[March](exh991q42025earningsrelease.htm)[2](exh991q42025earningsrelease.htm)[, 202](exh991q42025earningsrelease.htm)[6](exh991q42025earningsrelease.htm)[, regarding the Company's](exh991q42025earningsrelease.htm)[fourth](exh991q42025earningsrelease.htm)[quarter](exh991q42025earningsrelease.htm)[and full year 2025](exh991q42025earningsrelease.htm)[financial results](exh991q42025earningsrelease.htm)</u> |
| 104 | Cover Page Interactive Data File (embedded within the Inline XBRL document) |

---

------

**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

---

| | | |
|:---|:---|:---|
| Date: March 2, 2026 | **Xeris Biopharma Holdings, Inc.** | **Xeris Biopharma Holdings, Inc.** |
|  | By: | /s/ Steven M. Pieper |
|  |  | Name: Steven M. Pieper |
|  |  | Title: *Chief Financial Officer* |

---

## Exhibit 99.1

**Exhibit 99.1**

![picture1revised.jpg](picture1revised.jpg)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**&nbsp;&nbsp;&nbsp;&nbsp;**

**XERIS BIOPHARMA REPORTS RECORD PERFORMANCE FOR FOURTH QUARTER AND FULL YEAR 2025 AND PROVIDES FULL YEAR 2026 GUIDANCE**

Achieved record quarterly and full-year total revenue of $86 million and $292 million, respectively

Provides full year 2026 total revenue guidance range of $375 million to $390 million

Hosts conference call and webcast today at 8:30 a.m. ET

**CHICAGO, IL; March 2, 2026** – Xeris Biopharma Holdings, Inc. (Nasdaq: XERS), a fast-growing biopharmaceutical company committed to improving patient lives by developing and commercializing innovative products across a range of therapies, today announced financial results for the fourth quarter and full year ended December 31, 2025, and provides financial guidance for full year 2026.

"Thanks to the entire Xeris organization, 2025 was a transformational year, marked by focused execution, record revenue growth, and our emergence as a self-funding, sustainable biopharmaceutical company," said John Shannon, CEO. "As we enter 2026 from this position of strength, we remain focused on driving continued rapid revenue growth, the timely execution of XP-8121's ongoing development leading into the start of its Phase 3 clinical trial, and the judicious deployment of capital to further strengthen our business outlook in order to maximize long-term value for shareholders."

"Our exceptional results in 2025 reflect the strength of our business and set the stage for our future," said Steve Pieper, CFO. "As we look ahead to 2026, we will build on the strong momentum across our enterprise and expect total revenue to range from approximately $375 million to $390 million, representing more than 30% growth at the midpoint. This outlook will further strengthen our balance sheet, which will create even more financial flexibility to drive value in both the near and long term."

**<u>Fourth Quarter 2025 Highlights</u>**

---

| | | | |
|:---|:---|:---|:---|
| | **Three months ended December 31,** | **Three months ended December 31,** | **Change** |
| | **2025** | **2024** | $**%** |
| Product revenue (in thousands): |  |  |  |
| &nbsp;&nbsp;Recorlev | $45334 | $22614 | 100.5 |
| &nbsp;&nbsp;Gvoke | 24645 | 23262 | 5.9 |
| &nbsp;&nbsp;Keveyis | 12799 | 11124 | 15.1 |
| &nbsp;&nbsp;Other product revenue | 652 |  |  |
| Product revenue, net | 83430 | 57000 | 46.4 |
| Royalty, contract and other revenue | 2377 | 3099 | (23.3) |
| &nbsp;&nbsp;Total revenue | $85807 | $60099 | 42.8 |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• **Recorlev®** net revenue was $45.3 million – an increase of approximately 100% compared to the fourth quarter of 2024. This growth was due to increased patient demand.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• **Gvoke®** net revenue was $24.6 million – an increase of approximately 6% compared to the fourth quarter of 2024. The increase was due to favorable net pricing.

------

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• **Keveyis®** net revenue was $12.8 million – an increase of approximately 15% compared to the fourth quarter of 2024. This growth was due to increased patient demand.

**Cost of goods sold (COGS)** increased $1.5 million or 16% in the fourth quarter of 2025 compared to the same period last year. This increase was primarily due to an increase in product revenue.

**Research and development (R&D) expenses** increased $1.8 million or 29% in the fourth quarter of 2025 compared to the same period last year. The increase in R&D expenses primarily reflect higher expenses to support XP-8121.

**Selling, general and administrative (SG&A) expenses** increased $7.4 million or 18% in the fourth quarter of 2025 compared to the same period last year. This increase mainly reflects incremental personnel-related expenses.

**Net income** for the fourth quarter was $11.1 million, compared to a net loss of $5.1 million in the same period last year.

**Adjusted EBITDA**<sup>1</sup> for the fourth quarter was $25.1 million, an improvement of $16.8 million compared to the fourth quarter of 2024.

**<u>Full Year 2025 Highlights</u>**

---

| | | | |
|:---|:---|:---|:---|
| | **Twelve months ended December 31,** | **Twelve months ended December 31,** | **Change** |
| | **2025** | **2024** | $**%** |
| Product revenue (in thousands): |  |  |  |
| &nbsp;&nbsp;Recorlev | $139283 | $64277 | 116.7 |
| &nbsp;&nbsp;Gvoke | 94108 | 82829 | 13.6 |
| &nbsp;&nbsp;Keveyis | 47649 | 49530 | (3.8) |
| &nbsp;&nbsp;Other product revenue | 1963 |  |  |
| Product revenue, net | 283003 | 196636 | 43.9 |
| Royalty, contract and other revenue | 8842 | 6434 | 37.4 |
| &nbsp;&nbsp;Total revenue | $291845 | $203070 | 43.7 |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• **Recorlev®** net revenue was $139.3 million - an increase of approximately 117% compared to the year ended December 31, 2024. This growth was due to increased patient demand.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• **Gvoke®** net revenue was $94.1 million - an increase of approximately 14% compared to the year ended December 31, 2024. The increase was due to higher patient demand and favorable net pricing.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• **Keveyis®** net revenue was $47.6 million - a decrease of approximately 4% compared to the year ended December 31, 2024. The decrease was due to unfavorable net pricing, partially offset by higher patient demand.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• **Other product revenue** increased by $2.0 million for the year ended December 31, 2025. This includes sales of our products to commercialization partners.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• **Royalty, contract and other revenue** was $8.8 million and primarily reflects the recognition of milestones from partnership agreements.

**Cost of goods sold (COGS)** increased $5.7 million or 16% for the year ended December 31, 2025, compared to the same period in 2024. This increase was primarily due to an increase in product revenue.

**Research and development (R&D) expenses** increased $5.6 million or 22% for the year ended December 31, 2025, compared to the same period last year. The increase in R&D expenses primarily reflects personnel-related expenses to support our pipeline, primarily XP-8121.

<sup>1</sup> Adjusted EBITDA is a non-GAAP financial measure. See "Note Regarding Use of Non-GAAP Financial Measures" and the corresponding financial tables at the end of this press release for definitions and reconciliations of non-GAAP measures.

------

**Selling, general and administrative (SG&A) expenses** increased $18.9 million or 12% for the year ended December 31, 2025 compared to the same period last year. The increase mainly reflects higher personnel-related expense ($13.5 million), largely due to personnel-related expenses to support the commercial enterprise, including the Recorlev expansion.

**Net income** for the year ended December 31, 2025, was $0.6 million, compared to a net loss of $54.8 million in the prior year.

**Adjusted EBITDA**<sup>1</sup> for the year ended December 31, 2025 was $59.4 million, an improvement of $58.2 million compared to the year ended December 31, 2024.

**Total Shares Outstanding** were 172,431,290 at February 27, 2026.

**<u>2026 Outlook</u>**

Xeris provides 2026 full year financial guidance and expects:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Total revenue between $375 million to $390 million.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Gross margin to improve modestly compared to 2025 reflecting favorable product mix.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• R&D expense to increase by approximately $25 million compared to 2025 as the Company initiates its Phase 3 study for XP-8121.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• SG&A expense to increase by approximately $45 million compared to 2025, driven primarily by investments in Recorlev.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Adjusted EBITDA<sup>1</sup> to increase in total dollars compared to 2025.

**<u>Upcoming Events</u>**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• **Leerink Global Healthcare Conference**: Senior management will participate in 1x1 meetings on March 9, 2026 in Miami, FL. Please contact the sponsor to arrange meetings with management.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• **Barclays 28**<sup>th</sup> **Annual Global Healthcare Conference**: Senior management will participate in 1x1 meetings and a fireside chat, which will be webcast on March 10, 2026 in Miami, FL. Please contact the sponsor to arrange meetings with management.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• **Jefferies Biotech on the Beach Summit**: Senior management will participate in 1x1 virtual meetings on March 11, 2026 in Miami, FL. Please contact the sponsor to arrange meetings with management.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• **Needham Virtual Healthcare Conference**: Senior management will participate in 1x1 virtual meetings on April 13-16, 2026. Please contact the sponsor to arrange meetings with management.

**<u>Conference Call and Webcast Details</u>**

Xeris will host a conference call and webcast at 8:30 a.m. Eastern Time today to discuss the Company's financial and operational results. To pre-register for the conference call, please use the following link:

<u>https://events.q4inc.com/analyst/428274643?pwd=TZMrH35H</u>

After pre-registering, a confirmation email will be sent. To join the live webcast, please visit "Events" on the Investor Relations page, or use this link: <u>https://events.q4inc.com/attendee/428274643</u>. The Company recommends registering a minimum of ten minutes prior to the start of the call. A replay of the conference call will be available on the Company's Investor Relations site at: <u>https://xerispharma.com/investor-relations</u>.

**Note Regarding Use of Non-GAAP Financial Measures**

This press release includes financial results prepared in accordance with generally accepted accounting principles in the United States (GAAP) and also certain historical and forward-looking non-GAAP financial measures, namely Adjusted EBITDA. This non-GAAP financial measure is not meant to be considered in isolation and should be read in conjunction with the Company's consolidated financial statements prepared in accordance with GAAP, and was not prepared under any comprehensive set of accounting rules or principles. Non-GAAP financial measures are not an alternative for financial measures prepared in accordance with GAAP, and the calculation of the non-GAAP financial measure included herein may differ from similarly titled measures used by other companies. The Company believes that the presentation of Adjusted EBITDA, when viewed in conjunction with actual GAAP results, provides investors with a more meaningful understanding of the Company's ongoing and projected operating performance, exclusive of factors that do not directly affect what the Company considers to be its core operating performance, as well as unusual events. The Company believes this non-GAAP financial measure helps indicate underlying trends in the Company's business and is important in comparing current results with prior period results and understanding expected operating performance. Also, management uses this non-GAAP financial measure to establish budgets and operational goals, and to manage the Company's business and evaluate its performance. In addition, management believes that Adjusted EBITDA is important in evaluating the administrative costs of operating the Company's business.

<sup>1</sup> Adjusted EBITDA is a non-GAAP financial measure. See "Note Regarding Use of Non-GAAP Financial Measures" and the corresponding financial tables at the end of this press release for definitions and reconciliations of non-GAAP measures.

------

Adjusted EBITDA is GAAP net income (loss) before income tax (benefit) expense, plus interest and other income, less depreciation and amortization, interest expenses, share based compensation and debt refinancing fees.

**About Xeris** 

Xeris (Nasdaq: XERS) is a fast-growing biopharmaceutical company committed to improving patient lives by developing and commercializing innovative products across a range of therapies. Xeris has three commercially available products: Recorlev®, for the treatment of endogenous Cushing's syndrome; Gvoke®, a ready-to-use liquid glucagon for the treatment of severe hypoglycemia; and Keveyis®, a proven therapy for primary periodic paralysis. Xeris also has a pipeline of development programs led by XP-8121, a Phase 3-ready, once-weekly subcutaneous injection for hypothyroidism, as well as multiple early-stage programs leveraging Xeris' technology platforms, XeriSol® and XeriJect®, for its partners.

Xeris Biopharma Holdings is headquartered in Chicago, IL. For more information, visit www.xerispharma.com, or follow us on <u>X</u>, <u>LinkedIn</u>, or <u>Instagram</u>.

**Forward-Looking Statements**

Any statements in this press release other than statements of historical fact are forward-looking statements. Forward-looking statements include, but are not limited to, statements about future expectations, plans, opportunities, and prospects for Xeris Biopharma Holdings, Inc., including statements regarding financial guidance for full-year 2026, statements regarding its ability to continue to generate net income, Recorlev's growth potential, the ability to continue to demonstrate rapid revenue growth, the effectiveness of the Company's strategic execution, the Company's ability to continue on its current growth trajectory and continue to drive patient demand, advancing its strategic initiatives, its ability to create value, the ability to continue to demonstrate sustained momentum across the portfolio and the market and therapeutic potential of its products and product candidates, including its expectations regarding the timely execution of XP-8121's ongoing development leading into the start of its Phase 3 clinical trial, the potential utility of its formulation platforms, the advancement of its pipeline, and other statements containing the words "achieve," "anticipate," "continue," "will," "would," "continue," "expect," "should," "anticipate" and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. These forward-looking statements are based on numerous assumptions and assessments made in light of Xeris' experience and perception of historical trends, current conditions, business strategies, operating environment, future developments, geopolitical factors and other factors it believes appropriate. By their nature, forward-looking statements involve known and unknown risks and uncertainties because they relate to events and depend on circumstances that will occur in the future. The various factors that could cause Xeris' actual results (including revenue and sales in the near- and long-term), performance or achievements, industry results, market opportunity and developments to differ materially from those expressed in or implied by such forward-looking statements (including its 2026 guidance), include, but are not limited to, its financial position and need for financing, including to fund its product development programs or commercialization efforts, whether its products will achieve and maintain market acceptance in a competitive business environment, its reliance on third-party suppliers, including single-source suppliers, its reliance on third parties to conduct clinical trials, the ability of its product candidates to compete successfully with existing and new drugs, its and collaborators' ability to protect its intellectual property and proprietary technology, the accuracy and completeness of its assumptions and its ability to accurately estimate future financial results and market opportunities, and general macroeconomic and geopolitical conditions, including the possibility of an economic downturn, political unrest, trade disputes, changes in U.S. governmental priorities and resources, announced or implemented tariffs or export controls and market volatility. No assurance can be given that such expectations will be realized and persons reading this communication are, therefore, cautioned not to place undue reliance on these forward-looking statements. Additional risks and information about potential impacts of financial, operational, economic, competitive, regulatory, governmental, technological, and other factors that may affect Xeris can be found in Xeris' filings, including its most recently filed Annual Report on Form 10-K and subsequent filings with the U.S. Securities and Exchange Commission, the contents of which are not incorporated by reference into, nor do they form part of, this communication. The risks described herein and in Xeris' U.S. Securities and Exchange Commission filings are not the only risks the Company faces. Additional risks and uncertainties not currently known to it or that it currently deems immaterial may also impact its business operations or financial results. Forward-looking statements in this communication are based on information available to management, as of the date of this communication and, while the Company believes its assumptions are reasonable, actual results may differ materially. Subject to any obligations under applicable law, the Company does not undertake any obligation to update any forward-looking statement whether as a result of new information, future developments or otherwise, or to conform any forward-looking statement to actual results, future events, or to changes in expectations.

------

**Investor Contact**

Allison Wey

Senior Vice President, Investor Relations and Corporate Communications

awey@xerispharma.com

------

**XERIS BIOPHARMA HOLDINGS, INC.**

**CONSOLIDATED STATEMENTS OF OPERATIONS**

(in thousands, except share and per share data)

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended December 31,** | **Three Months Ended December 31,** | **Years Ended <br>December 31,** | **Years Ended <br>December 31,** |
| | **2025** | **2024** | **2025** | **2024** |
| | (unaudited) | (unaudited) | | |
| Product revenue, net | $83430 | $57000 | $283003 | $196636 |
| Royalty, contract and other revenue | 2377 | 3099 | 8842 | 6434 |
| Total revenue | 85807 | 60099 | 291845 | 203070 |
| Costs and expenses: |  |  |  |  |
| &nbsp;&nbsp;Cost of goods sold | 10947 | 9478 | 42569 | 36832 |
| &nbsp;&nbsp;&nbsp;&nbsp;Research and development | 7874 | 6092 | 31165 | 25560 |
| &nbsp;&nbsp;&nbsp;&nbsp;Selling, general and administrative | 47502 | 40139 | 182372 | 163481 |
| &nbsp;&nbsp;&nbsp;&nbsp;Amortization of intangible assets | 2711 | 2711 | 10843 | 10843 |
| &nbsp;&nbsp;&nbsp;&nbsp; Total costs and expenses | 69034 | 58420 | 266949 | 236716 |
| Income (loss) from operations | 16773 | 1679 | 24896 | (33646) |
| Other expenses | (5692) | (6792) | (24342) | (23458) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net income (loss) before benefit from income taxes | 11081 | (5113) | 554 | (57104) |
| Income tax benefit |  |  |  | 2268 |
| &nbsp;&nbsp;&nbsp;&nbsp; Net income (loss) | $11081 | $(5113) | $554 | $(54836) |
| Net income (loss) per common share - basic | $0.07 | $(0.03) | $— | $(0.37) |
| Net income (loss) per common share - diluted | $0.06 | $(0.03) | $— | $(0.37) |
| Weighted average common shares outstanding |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp; Basic | 165961552 | 149092881 | 160425198 | 146772758 |
| &nbsp;&nbsp;&nbsp;&nbsp; Diluted | 180071915 | 149092881 | 172742720 | 146772758 |

---

------

**XERIS BIOPHARMA HOLDINGS, INC.**

**Non-GAAP Financial Measures - EBITDA and Adjusted EBITDA**

(in thousands, unaudited)

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended December 31,** | **Three Months Ended December 31,** | **Years Ended <br>December 31,** | **Years Ended <br>December 31,** |
| | **2025** | **2024** | **2025** | **2024** |
| GAAP Net income (loss) | $11081 | $(5113) | $554 | $(54836) |
| Adjustments |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Interest and other income | (1461) | (910) | (4742) | (5321) |
| &nbsp;&nbsp;&nbsp;&nbsp;Interest expense | 7153 | 7703 | 29084 | 30485 |
| &nbsp;&nbsp;&nbsp;&nbsp;Income tax benefit |  |  |  | (2268) |
| &nbsp;&nbsp;&nbsp;&nbsp;Depreciation and amortization | 3046 | 3024 | 12156 | 12070 |
| EBITDA | $19819 | $4704 | $37052 | $(19870) |
| Adjustments |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Share-based compensation (a) | 5272 | 3595 | 22366 | 18363 |
| &nbsp;&nbsp;&nbsp;&nbsp;Debt refinancing fees (b) |  |  |  | 2690 |
| Adjusted EBITDA | $25091 | $8299 | $59418 | $1183 |

---

(a) Includes non-cash, stock-based compensation, net of forfeitures.

(b) Represents non-recurring fees related to financing activities. Including debt refinancing fees which related to advisory and legal fees to refinance the Hayfin term loan in 2024.

------

**XERIS BIOPHARMA HOLDINGS, INC.**

**CONDENSED CONSOLIDATED BALANCE SHEETS**

(in thousands)

---

| | | |
|:---|:---|:---|
| | **December 31, 2025** | **December 31, 2024** |
| **Assets** | | |
| Current assets: |  |  |
| &nbsp;&nbsp;&nbsp;Cash and cash equivalents | $111042 | $71621 |
| &nbsp;&nbsp;&nbsp;Trade accounts receivable, net | 51050 | 40415 |
| &nbsp;&nbsp;&nbsp;Inventory, net | 68673 | 48175 |
| &nbsp;&nbsp;&nbsp;Prepaid expenses and other current assets | 9548 | 7451 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total current assets | 240313 | 167662 |
| Property and equipment, net | 4945 | 5562 |
| Operating lease right-of-use assets | 22112 | 22649 |
| Goodwill | 22859 | 22859 |
| Intangible assets, net | 88078 | 98921 |
| Other assets | 5220 | 5407 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total assets | $383527 | $323060 |
| **Liabilities and Stockholders' Equity (deficit)** |  |  |
| Current liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;Accounts payable | $3076 | $2290 |
| &nbsp;&nbsp;&nbsp;Current portion of long-term debt |  | 15102 |
| &nbsp;&nbsp;&nbsp;Current operating lease liabilities | 6232 | 6080 |
| &nbsp;&nbsp;&nbsp;Other accrued liabilities | 33155 | 27716 |
| &nbsp;&nbsp;&nbsp;Accrued trade discounts and rebates | 43253 | 29084 |
| &nbsp;&nbsp;&nbsp;Accrued returns reserve | 18969 | 19082 |
| &nbsp;&nbsp;&nbsp;Other current liabilities | 4889 | 1089 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total current liabilities | 109574 | 100443 |
| Long-term debt, net of unamortized debt issuance costs | 220335 | 217006 |
| Non-current operating lease liabilities | 31531 | 33259 |
| Other liabilities | 8398 | 1967 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total liabilities | 369838 | 352675 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total stockholders' equity (deficit) | 13689 | (29615) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total liabilities and stockholders' equity (deficit) | $383527 | $323060 |

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