# EDGAR Filing Document

**Accession Number:** 0001824893
**File Stem:** 0001193125-26-120018
**Filing Date:** 2026-3
**Character Count:** 33239
**Document Hash:** 2519443f22239b94e883efe3a6994c59
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-26-120018.hdr.sgml**: 20260323

**ACCESSION NUMBER**: 0001193125-26-120018

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 15

**FILED AS OF DATE**: 20260323

**DATE AS OF CHANGE**: 20260323

**EFFECTIVENESS DATE**: 20260323

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Surrozen, Inc./DE
- **CENTRAL INDEX KEY:** 0001824893
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 301374889
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-294543
- **FILM NUMBER:** 26783393

**BUSINESS ADDRESS:**
- **STREET 1:** 171 OYSTER POINT BLVD
- **STREET 2:** SUITE 400
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080
- **BUSINESS PHONE:** 650-475-2820

**MAIL ADDRESS:**
- **STREET 1:** 171 OYSTER POINT BLVD
- **STREET 2:** SUITE 400
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Consonance-HFW Acquisition Corp.
- **DATE OF NAME CHANGE:** 20200915

**As filed with the U.S. Securities and Exchange Commission on March 23, 2026**

**Registration No. 333-** 

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**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**WASHINGTON, DC 20549**

------

**FORM S-8** 

**REGISTRATION STATEMENT** 

***UNDER*** 

***THE SECURITIES ACT OF 1933*** 

------

**Surrozen, Inc.**

**(Exact Name of Registrant as Specified in its Charter)**

------

---

| | |
|:---|:---|
| **Delaware** | **30-1374889** |
| **(State or other jurisdiction of**<br>**incorporation or organization)** | **(I.R.S. Employer<br>Identification No.)** |

---

**171 Oyster Point Blvd, Suite 300** 

**South San Francisco, CA 94080** 

**(650) 489-9000** 

**(Address of principal executive offices, including zip code)** 

**Surrozen, Inc. 2021 Equity Incentive Plan** 

**Surrozen, Inc. 2021 Employee Stock Purchase Plan** 

**(Full titles of the plans)** 

**Craig Parker** 

**President and Chief Executive Officer** 

**Surrozen, Inc.** 

**171 Oyster Point Blvd, Suite 400** 

**South San Francisco, CA 94080** 

**(650) 489-9000** 

**(Name, address and telephone number, including area code, of agent for service)** 

***Copy to:***

**John T. McKenna**

**Cooley LLP**

**3175 Hanover Street**

**Palo Alto, CA 94304**

**(650) 843-5000**

------

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☐ | Accelerated filer | ☐ |
| Non-accelerated filer | ☒ | Smaller reporting company | ☒ |
|  |  | Emerging growth company | ☐ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

------

**EXPLANATORY NOTE** 

This Registration Statement on Form S-8 is being filed by Surrozen, Inc. (the "Registrant") with the Securities and Exchange Commission (the "Commission") for the purpose of registering (i) an additional 1,543,003 shares of the Registrant's common stock, par value $0.0001 per share, to be issued pursuant to the Registrant's 2021 Equity Incentive Plan (the "2021 Plan") and (ii) an additional 63,288 shares of common stock to be issued pursuant to the Registrant's 2021 Employee Stock Purchase Plan (the "2021 ESPP").

The Registrant previously registered shares of its common stock for issuance under the 2021 Plan and 2021 ESPP under registration statements on Form S-8 filed with the Commission on [<u>March 31, 2025</u>](https://www.sec.gov/Archives/edgar/data/1824893/000095017025047810/srzn_s-8_20250331.htm) (File No. 333-286269), [<u>April 10, 2024</u>](https://www.sec.gov/Archives/edgar/data/1824893/000095017024043414/srzn_s-8_20240410.htm) (File No. 333-278608), [<u>March 31, 2023</u>](https://www.sec.gov/Archives/edgar/data/1824893/000095017023011127/srzn_s-8_202303.htm) (File No. 333-271017), [<u>March 29, 2022</u>](https://www.sec.gov/Archives/edgar/data/1824893/000119312522087116/d328991ds8.htm) (File No. 333-263924) and [<u>November 8, 2021</u>](https://www.sec.gov/Archives/edgar/data/1824893/000119312521322353/d193764ds8.htm) (File No. 333-260858). The contents of the previous registration statements referenced above, to the extent not otherwise amended or superseded by the contents hereof, are incorporated by reference into this Registration Statement pursuant to General Instruction E of Form S-8.

**Part I** 

**INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS** 

As permitted by the rules of the Commission, this Registration Statement omits the information specified in Part I of Form S-8. The documents containing the information specified in Part I will be delivered to the participants in the 2021 Plan and the 2021 ESPP, as applicable, as required by Rule 428(b)(1) under the Securities Act of 1933, as amended.

**Part II** 

**INFORMATION REQUIRED IN THE REGISTRATION STATEMENT** 

**Item 3. Incorporation of Documents by Reference.**

The following documents filed by the Registrant with the Commission are incorporated by reference into this Registration Statement:

**(a)** The Registrant's Annual Report on Form 10-K (File No. 001-39635) for the year ended December 31, 2025 filed with the Commission on [<u>March 23, 2026</u>](https://www.sec.gov/Archives/edgar/data/1824893/000119312526119818/srzn-20251231.htm) .

**(b)** The Registrant's Current Report on Form 8-K (File No. 001-39635) filed with the Commission on [<u>January 30, 2026</u>](https://www.sec.gov/ix?doc=/Archives/edgar/data/0001824893/000119312526031798/srzn-20260126.htm) .

**(c)** The description of the Registrant's common stock which is contained in [<u>Exhibit 4.3</u>](https://www.sec.gov/Archives/edgar/data/1824893/000095017025047712/srzn-ex4_3.htm) to the Registrant's Annual Report on Form 10-K for the year ended December 31, 2024 filed with the Commission on March 31, 2025 (File No. 001-39635).

**(d)** All other reports and documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, as amended (other than Current Reports furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits furnished on such form that relate to such items) on or after the date of this Registration Statement and prior to the filing of a post-effective amendment to this Registration Statement which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part of this Registration Statement from the date of the filing of such reports and documents. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently filed document that also is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.

**Item 4. Description of Securities.**

Not applicable.

**Item 5. Interests of Names Experts and Counsel.**

Not applicable.

------

**Item 6. Indemnification of Directors and Officers.** 

Section 145 of the Delaware General Corporation Law (the "DGCL") provides that a corporation may indemnify directors and officers as well as other employees and individuals against expenses (including attorneys' fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by such person in connection with any threatened, pending or completed actions, suits or proceedings in which such person is made a party by reason of such person being or having been a director, officer, employee or agent of the Registrant. The DGCL provides that Section 145 is not exclusive of other rights to which those seeking indemnification may be entitled under any bylaws, agreement, vote of stockholders or disinterested directors or otherwise. The Registrant's certificate of incorporation and bylaws provide for indemnification by the Registrant of its directors and officers to the fullest extent permitted by the DGCL.

The Registrant has entered into indemnification agreements with each of its directors and executive officers to provide contractual indemnification in addition to the indemnification provided in the Registrant's certificate of incorporation. Each indemnification agreement provides for indemnification and advancements by the Registrant of certain expenses and costs relating to claims, suits or proceedings arising from his or her service to the Registrant or, at the Registrant's request, service to other entities, as officers or directors to the maximum extent permitted by applicable law.

The Registrant also maintains standard policies of insurance under which coverage is provided (1) to its directors and officers against loss arising from claims made by reason of breach of duty or other wrongful act, while acting in their capacity as directors and officers of the Registrant, and (2) to the Registrant with respect to payments which may be made by the Registrant to such officers and directors pursuant to any indemnification provision contained in the Registrant's certificate of incorporation and bylaws or otherwise as a matter of law.

**Item 7. Exemption From Registration Claimed.**

Not applicable.

**Item 8. Exhibits.**

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| **Exhibit <br>Number** | | **Incorporated by Reference** | **Incorporated by Reference** | **Incorporated by Reference** | **Incorporated by Reference** |
| **Exhibit <br>Number** | <br>**Exhibit Description** | **Form** | **File No.** | **Exhibit** | **Filing Date** |
| 4.1 | [<u>Certificate of Incorporation of Surrozen, Inc.</u>](https://www.sec.gov/Archives/edgar/data/1824893/000119312521249342/d184950dex31.htm) | 8-K | 001-39635 | 3.1 | August 17, 2021 |
| 4.2 | [<u>Certificate of Amendment to the Certificate of Incorporation of Surrozen, Inc.</u>](https://www.sec.gov/Archives/edgar/data/1824893/000095017023070103/srzn-ex3_1.htm) | 8-K | 001-39635 | 3.1 | December 13, 2023 |
| 4.3 | [<u>Amended and Restated Bylaws of Surrozen, Inc.</u>](https://www.sec.gov/Archives/edgar/data/1824893/000095017023053312/srzn-ex3_1.htm) | 8-K | 001-39635 | 3.1 | October 13, 2023 |
| 4.4 | [<u>Specimen Warrant Certificate.</u>](https://www.sec.gov/Archives/edgar/data/1824893/000110465920114246/tm2030948d4_ex4-3.htm) | S-1/A | 333-249394 | 4.3 | October 13, 2020 |
| 4.5 | [<u>Amended and Restated Warrant Agreement, dated as of March 31, 2023, by and between Surrozen, Inc. and Continental Stock Transfer & Trust Company.</u>](https://www.sec.gov/Archives/edgar/data/1824893/000095017023011118/srzn-ex4_6.htm) | 10-K | 001-39635 | 4.6 | March 31, 2023 |
| 5.1\* | [<u>Opinion of Cooley LLP.</u>](srzn-ex5_1.htm) |  |  |  |  |
| 23.1\* | [<u>Consent of Ernst & Young LLP, independent registered public accounting firm.</u>](srzn-ex23_1.htm) |  |  |  |  |
| 23.2\* | [<u>Consent of Cooley LLP (included in Exhibit 5.1 hereto).</u>](srzn-ex5_1.htm) |  |  |  |  |
| 24.1\* | [<u>Power of Attorney (included on the signature page hereto).</u>](#sig) |  |  |  |  |
| 99.1 | [<u>Surrozen, Inc. 2021 Equity Incentive Plan.</u>](https://www.sec.gov/Archives/edgar/data/1824893/000095017024043399/srzn-ex10_2.htm) | 10-K | 001-39635 | 10.2 | April 10, 2024 |
| 99.2 | [<u>Surrozen, Inc. 2021 Employee Stock Purchase Plan.</u>](https://www.sec.gov/Archives/edgar/data/1824893/000095017024043399/srzn-ex10_5.htm) | 10-K | 001-39635 | 10.5 | April 10, 2024 |
| 107\* | [<u>Filing Fee Table</u>](srzn_exfilingfees.htm) |  |  |  |  |

---

\* Filed herewith.

**Item 9. Undertakings.** 

**1.** The undersigned registrant hereby undertakes:

**(a)** To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:

**(i)** To include any prospectus required by section 10(a)(3) of the Securities Act of 1933;

**(ii)** To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than 20% change in the maximum aggregate offering price set forth in the "Calculation of Filing Fee Tables" in the effective registration statement; and

------

**(iii)** To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement;

*provided, however,* that paragraphs (a)(i) and (a)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the registrant pursuant to section 13 or section 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in the registration statement.

**(b)** That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

**(c)** To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

**2.** The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act of 1933, each filing of the registrant's annual report pursuant to section 13(a) or section 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan's annual report pursuant to section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

**3**. Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act of 1933 and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act of 1933 and will be governed by the final adjudication of such issue.

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**SIGNATURES** 

Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of South San Francisco, State of California, on March 23, 2026.

---

| | |
|:---|:---|
| **SURROZEN, INC.** | **SURROZEN, INC.** |
| By: | /s/ *Craig Parker* |
|  | Craig Parker |
|  | President and Chief Executive Officer |

---

------

**POWER OF ATTORNEY** 

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Craig Parker and Andrew Maleki, and each one of them, as his or her true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution, for him or her and in their name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents or any of them, or his or her substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

---

| | | |
|:---|:---|:---|
| **Signature** | **Title** | **Date** |
| /s/ Craig Parker<br>**Craig Parker** | President and Chief Executive Officer and Director<br>*(Principal Executive Officer)* | March 23, 2026 |
| /s/ Andrew Maleki<br>**Andrew Maleki** | Chief Financial Officer<br>*(Principal Financial and Accounting Officer)* | March 23, 2026<br>|
| /s/ David J. Woodhouse, Ph.D.<br>**David J. Woodhouse, Ph.D.** | Chair of the Board of Directors | March 23, 2026<br>|
| /s/ Anna Berkenblit, M.D. | Director | March 23, 2026 |
| **Anna Berkenblit, M.D.** |  |  |
| **/s/** Eric Bjerkholt | Director | March 23, 2026 |
| **Eric Bjerkholt** |  |  |
| /s/ Christopher Chai | Director | March 23, 2026 |
| **Christopher Chai** |  |  |
| /s/ Mary Haak-Frendscho, Ph.D. | Director | March 23, 2026 |
| **Mary Haak-Frendscho, Ph.D.** |  |  |
| **/s/** Mace Rothenberg, M.D. | Director | March 23, 2026 |
| **Mace Rothenberg, M.D.** |  |  |
| /s/ Tim Kutzkey, Ph.D. | Director | March 23, 2026 |
| **Tim Kutzkey, Ph.D.** |  |  |

---

------

## Exhibit 5.1

**Exhibit 5.1**![img200110477_0.gif](img200110477_0.gif)

John T. McKenna

+1 650 843 5059

jmckenna@cooley.com

March 23, 2026

Surrozen, Inc.

171 Oyster Point Blvd, Suite 400

South San Francisco, CA 94080

**Re: Registration Statement on Form S-8**

Ladies and Gentlemen:

We have acted as counsel to Surrozen, Inc., a Delaware corporation (the "***Company***"), in connection with the filing by the Company of a Registration Statement on Form S-8 (the "***Registration Statement***") with the Securities and Exchange Commission (the "***Commission***") covering the offering of up to 1,606,291 shares (the "***Shares***") of the Company's common stock, par value $0.0001 per share ("***Common Stock***"), consisting of (a) 1,543,003 shares of Common Stock issuable pursuant to the Company's 2021 Equity Incentive Plan (the "***EIP***"), and (b) 63,288 shares of Common Stock issuable pursuant to the Company's 2021 Employee Stock Purchase Plan (together with the EIP, the "***Plans***").

In connection with this opinion, we have examined and relied upon (a) the Registration Statement and the related prospectuses, (b) the Plans, (c) the Company's certificate of incorporation and bylaws, each as currently in effect, and (d) such other records, documents, opinions, certificates, memoranda, and instruments as in our judgment are necessary or appropriate to enable us to render the opinion expressed below. We have assumed the genuineness of all signatures, the authenticity of all documents submitted to us as originals, the conformity to originals of all documents submitted to us as copies, the accuracy, completeness and authenticity of certificates of public officials, and the due authorization, execution and delivery of all documents by all persons other than the Company. As to certain factual matters, we have relied upon a certificate of an officer of the Company and have not independently verified such matters.

We note that the Company was initially incorporated under the laws of the Cayman Islands and was domesticated as a corporation in the State of Delaware (the "***Domestication***") in accordance with Section 388 of the Delaware General Corporation Law (the "***DGCL***"). We have assumed all matters determinable under the laws of the Cayman Islands, including without limitation that the approval of the Plans by the board and shareholders of the Company as a Cayman Islands exempted company prior to the Domestication were done in accordance with the applicable governing documents of the Company and the laws of the Cayman Islands.

Our opinion is expressed only with respect to the DGCL. We express no opinion to the extent that any other laws are applicable to the subject matter hereof and express no opinion and provide no assurance as to compliance with any federal or state securities law, rule or regulation.

On the basis of the foregoing, and in reliance thereon, we are of the opinion that the Shares, when sold and issued in accordance with the Plans, the Registration Statement and the related prospectuses, will be validly issued, fully paid, and nonassessable (except as to shares issued pursuant to deferred payment arrangements, which will be fully paid and nonassessable when such deferred payments are made in full).

Cooley LLP 3175 Hanover Street Palo Alto, CA 94304-1130<br>t: (650) 843-5000 f: (650) 849-7400 cooley.com

------

![img200110477_1.gif](img200110477_1.gif)

Surrozen, Inc.

March 23, 2026

Page two

This opinion is limited to the matters expressly set forth in this letter, and no opinion has been or should be implied, or may be inferred, beyond the matters expressly stated. This opinion speaks only as to law and facts in effect or existing as of the date hereof, and we have no obligation or responsibility to update or supplement this opinion to reflect any facts or circumstances that may hereafter come to our attention or any changes in law that may hereafter occur.

We consent to the filing of this opinion as an exhibit to the Registration Statement. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act of 1933, as amended, or the rules and regulations of the Commission thereunder.

Sincerely,

**Cooley LLP**

By: <u>/s/ John T. McKenna</u> 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;John T. McKenna

Cooley LLP 3175 Hanover Street Palo Alto, CA 94304-1130<br>t: (650) 843-5000 f: (650) 849-7400 cooley.com

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## Exhibit 23.1

Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the Registration Statement (Form S-8) pertaining to the Surrozen, Inc. 2021 Equity Incentive Plan and 2021 Employee Stock Purchase Plan of our report dated March 23, 2026, with respect to the consolidated financial statements of Surrozen, Inc., included in its Annual Report (Form 10-K) for the year ended December 31, 2025, filed with the Securities and Exchange Commission.

/s/ Ernst & Young LLP

San Francisco, California

March 23, 2026

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## Ex-Filing

?xml version='1.0' encoding='ASCII'? EX-FILING FEES

**Exhibit 107**

**CALCULATION OF** FILING FEE **TABLES**

**Form** S-8

(Form Type)

Surrozen, Inc.

(Exact Name of Registrant as Specified in its Charter)

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;**Table 1: Newly Registered Securities** | &nbsp;&nbsp;**Table 1: Newly Registered Securities** | &nbsp;&nbsp;**Table 1: Newly Registered Securities** | &nbsp;&nbsp;**Table 1: Newly Registered Securities** | &nbsp;&nbsp;**Table 1: Newly Registered Securities** | &nbsp;&nbsp;**Table 1: Newly Registered Securities** | &nbsp;&nbsp;**Table 1: Newly Registered Securities** | &nbsp;&nbsp;**Table 1: Newly Registered Securities** | &nbsp;&nbsp;**Table 1: Newly Registered Securities** |
|  | &nbsp;&nbsp;**Security Type** | &nbsp;&nbsp;**Security Class Title** | &nbsp;&nbsp;**Fee Calculation Rule** | &nbsp;&nbsp;**Amount Registered** | &nbsp;&nbsp;**Proposed Maximum Offering Price Per Unit** | &nbsp;&nbsp;**Maximum Aggregate Offering Price** | &nbsp;&nbsp;**Fee Rate** | &nbsp;&nbsp;**Amount of Registration Fee** |
| &nbsp;&nbsp;1 | &nbsp;&nbsp;Equity | &nbsp;&nbsp;Common stock, $0.0001 par value per share, 2021 Equity Incentive Plan | &nbsp;&nbsp;Other | &nbsp;&nbsp;807948 | &nbsp;&nbsp;$25.18 | &nbsp;&nbsp;$20344130.64 | &nbsp;&nbsp;0.00013810 | &nbsp;&nbsp;$2809.53 |
| &nbsp;&nbsp;2 | &nbsp;&nbsp;Equity | &nbsp;&nbsp;Common stock, $0.0001 par value per share, 2021 Equity Incentive Plan | &nbsp;&nbsp;Other | &nbsp;&nbsp;735055 | &nbsp;&nbsp;$24.52 | &nbsp;&nbsp;$18023548.60 | &nbsp;&nbsp;0.00013810 | &nbsp;&nbsp;$2489.06 |
| &nbsp;&nbsp;3 | &nbsp;&nbsp;Equity | &nbsp;&nbsp;Common stock, $0.0001 par value per share, 2021 Employee Stock Purchase Plan | &nbsp;&nbsp;Other | &nbsp;&nbsp;63288 | &nbsp;&nbsp;$21.41 | &nbsp;&nbsp;$1354996.08 | &nbsp;&nbsp;0.00013810 | &nbsp;&nbsp;$187.13 |
| &nbsp;&nbsp;**Total Offering Amounts** | &nbsp;&nbsp;**Total Offering Amounts** | &nbsp;&nbsp;**Total Offering Amounts** | &nbsp;&nbsp;**Total Offering Amounts** | &nbsp;&nbsp;**Total Offering Amounts** | &nbsp;&nbsp;**–** | &nbsp;&nbsp;**$39722675.32** | &nbsp;&nbsp;**–** | &nbsp;&nbsp;**$5485.72** |
| &nbsp;&nbsp;**Total Fee Offsets** | &nbsp;&nbsp;**Total Fee Offsets** | &nbsp;&nbsp;**Total Fee Offsets** | &nbsp;&nbsp;**Total Fee Offsets** | &nbsp;&nbsp;**Total Fee Offsets** | &nbsp;&nbsp;**–** | &nbsp;&nbsp;**–** | &nbsp;&nbsp;**–** | &nbsp;&nbsp;**$0.00** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**Net Fee Due** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**Net Fee Due** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**Net Fee Due** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**Net Fee Due** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**Net Fee Due** | &nbsp;&nbsp;**–** | &nbsp;&nbsp;**–** | &nbsp;&nbsp;**–** | &nbsp;&nbsp;**$5485.72** |

---

**Offering Note**

**(1)** **A.** Pursuant to Rule 416(a) promulgated under the Securities Act of 1933, as amended (the "***Securities Act***"), this Registration Statement shall also cover any additional shares of common stock, $0.0001 par value per share ("***Common Stock***") of Surrozen, Inc. (the "***Registrant***") that become issuable under the Registrant's 2021 Equity Incentive Plan (the "***2021 Plan***") and the Registrant's 2021 Employee Stock Purchase Plan (the "***2021 ESPP***") by reason of any stock dividend, stock split, recapitalization, or other similar transaction effected that results in an increase to the number of outstanding shares of the Registrant's Common Stock, as applicable.

**B.** The proposed maximum offering price per unit is estimated in accordance with Rules 457(c) and (h) under the Securities Act solely for the purpose of calculating the registration fee on the basis of $25.18 per share of Common Stock, which represents the average of the high and low prices of the Registrant's Common Stock as reported on The Nasdaq Stock Market on March 16, 2026.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**C.** The amount registered represents in the aggregate 1,543,003 additional shares of the Registrant's Common Stock that were added to the shares authorized for issuance under the 2021 Plan pursuant to an annual "evergreen" increase provision contained in the 2021 Plan. Pursuant to such provision, the number of shares reserved for issuance under the 2021 Plan will increase on the first day of each calendar year, starting on January 1, 2022 and continuing through January 1, 2031, by the lesser of (a) 5% of the Fully-Diluted Common Stock (as defined in the 2021 Plan) on December 31st of the preceding year or (b) a number of shares of the Registrant's common stock determined by the Registrant's board of directors prior to the date of the increase.

**(2)** **A.** See Note 1A.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**B.** The proposed maximum offering price per unit is estimated in accordance with Rule 457(h) under the Securities Act solely for the purpose of calculating the registration fee on the basis of $24.52 per share of Common Stock, which represents the weighted average exercise price of stock options outstanding under the 2021 Plan immediately prior to the filing of this registration statement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**C.** See Note 1C.

**(3)** **A.** See Note 1A.

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**B.** The proposed maximum offering price per unit is estimated in accordance with Rules 457(c) and (h) under the Securities Act solely for the purpose of calculating the registration fee on the basis of $21.41 per share of Common Stock, which represents the average of the high and low prices of the Registrant's Common Stock as reported on The Nasdaq Stock Market on March 16, 2026, multiplied by 85%, which is the percentage of the price per share applicable to shares issued under the 2021 ESPP.

**C.** The amount registered represents 63,288 additional shares of the Registrant's Common Stock that were added to the shares authorized for issuance under the 2021 ESPP pursuant to an annual "evergreen" increase provision contained in the 2021 ESPP. Pursuant to such provision, the number of shares reserved for issuance under the 2021 ESPP will increase on the first day of each calendar year, starting on January 1, 2022 and continuing through January 1, 2031, by the lesser of (a) 1% of the Fully-Diluted Common Stock (as defined in the 2021 ESPP) on December 31st of the preceding calendar year, and (b) 63,288 shares of Common Stock. Shares subject to purchase rights granted under the 2021 ESPP that terminate without having been exercised in full will not reduce the number of shares available for issuance under the 2021 ESPP.

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| | | | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| **Table 2: Fee Offset Claims and Sources**<br>**☑ Not Applicable** | **Table 2: Fee Offset Claims and Sources**<br>**☑ Not Applicable** | **Table 2: Fee Offset Claims and Sources**<br>**☑ Not Applicable** | **Table 2: Fee Offset Claims and Sources**<br>**☑ Not Applicable** | **Table 2: Fee Offset Claims and Sources**<br>**☑ Not Applicable** | **Table 2: Fee Offset Claims and Sources**<br>**☑ Not Applicable** | **Table 2: Fee Offset Claims and Sources**<br>**☑ Not Applicable** | **Table 2: Fee Offset Claims and Sources**<br>**☑ Not Applicable** | **Table 2: Fee Offset Claims and Sources**<br>**☑ Not Applicable** | **Table 2: Fee Offset Claims and Sources**<br>**☑ Not Applicable** | **Table 2: Fee Offset Claims and Sources**<br>**☑ Not Applicable** | **Table 2: Fee Offset Claims and Sources**<br>**☑ Not Applicable** |
|  | **Registrant or Filer Name** | **Form or Filing Type** | **File Number** | **Initial Filing Date** | **Filing Date** | **Fee Offset Claimed** | **Security Type Associated with Fee Offset Claimed** | **Security Title Associated with Fee Offset Claimed** | **Unsold Securities Associated with Fee Offset Claimed** | **Unsold Aggregate Offering Amount Associated with Fee Offset Claimed** | **Fee Paid with Fee Offset Source** |
| **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** | **Rule 457(p)** |
| Fee Offset Claims | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Fee Offset Sources | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |

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