# EDGAR Filing Document

**Accession Number:** 0002026172
**File Stem:** 0001892688-26-000036
**Filing Date:** 2026-2
**Character Count:** 18775
**Document Hash:** 6d36ea25ccd853c5e5e6e46818139d50
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001892688-26-000036.hdr.sgml**: 20260217

**ACCESSION NUMBER**: 0001892688-26-000036

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20251231

**FILED AS OF DATE**: 20260217

**DATE AS OF CHANGE**: 20260217

**EFFECTIVENESS DATE**: 20260217

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** DIADEMA PARTNERS LP
- **CENTRAL INDEX KEY:** 0002026172

**ORGANIZATION NAME:**
- **EIN:** 991928849
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-25172
- **FILM NUMBER:** 26637744

**BUSINESS ADDRESS:**
- **STREET 1:** 2140 HEADQUARTERS PLAZA
- **STREET 2:** EAST TOWER, 2ND FLOOR
- **CITY:** MORRISTOWN
- **STATE:** NJ
- **ZIP:** 07960
- **BUSINESS PHONE:** 917-513-8539

**MAIL ADDRESS:**
- **STREET 1:** 2140 HEADQUARTERS PLAZA
- **STREET 2:** EAST TOWER, 2ND FLOOR
- **CITY:** MORRISTOWN
- **STATE:** NJ
- **ZIP:** 07960

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2025

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** DIADEMA PARTNERS LP<br>**Address:** 2140 HEADQUARTERS PLAZA<br>EAST TOWER 2ND FLOOR<br>MORRISTOWN, NJ 07960

**Form 13F File Number:** 028-25172

**CRD Number (if applicable):** 000331527

**SEC File Number (if applicable):** 801-130477

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** ZACHARY CANONICO<br>**Title:** CHIEF COMPLIANCE OFFICER AND CHIEF OPERATING OFFICER<br>**Phone:** 646-979-8432

**Signature, Place, and Date of Signing:**

ZACHARY CANONICO  MORRISTOWN, NJ  02-17-2026<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 145

**Form 13F Information Table Value Total:** $580539432

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| AARDVARK THERAPEUTICS INC | COM | 002942100 |  | 208451 | 15882 | SH |  | SOLE |  | 15882 | 0 | 0 |
| ABIVAX SA | SPONSORED ADS | 00370M103 |  | 10200972 | 75644 | SH |  | SOLE |  | 75644 | 0 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 |  | 2123849 | 5341 | SH |  | SOLE |  | 5341 | 0 | 0 |
| ALTIMMUNE INC | COM NEW | 02155H200 |  | 1775398 | 491800 | SH | Call | SOLE |  | 491800 | 0 | 0 |
| ANAVEX LIFE SCIENCES CORP | COM NEW | 032797300 |  | 500536 | 140600 | SH | Call | SOLE |  | 140600 | 0 | 0 |
| ANI PHARMACEUTICALS INC | COM | 00182C103 |  | 4211765 | 53354 | SH |  | SOLE |  | 53354 | 0 | 0 |
| ANNEXON INC | COM | 03589W102 |  | 1757000 | 350000 | SH |  | SOLE |  | 350000 | 0 | 0 |
| ANNEXON INC | COM | 03589W102 |  | 1551682 | 309100 | SH | Call | SOLE |  | 309100 | 0 | 0 |
| APOGEE THERAPEUTICS INC | COM | 03770N101 |  | 15933828 | 211100 | SH | Call | SOLE |  | 211100 | 0 | 0 |
| APPLIED THERAPEUTICS INC | COM | 03828A101 |  | 2020 | 20200 | SH | Call | SOLE |  | 20200 | 0 | 0 |
| AQUESTIVE THERAPEUTICS INC | COM | 03843E104 |  | 1363706 | 211100 | SH | Call | SOLE |  | 211100 | 0 | 0 |
| AQUESTIVE THERAPEUTICS INC | COM | 03843E104 |  | 2181542 | 337700 | SH | Put | SOLE |  | 337700 | 0 | 0 |
| ARBUTUS BIOPHARMA CORP | COM | 03879J100 |  | 2638766 | 548600 | SH | Call | SOLE |  | 548600 | 0 | 0 |
| ARDELYX INC | COM | 039697107 |  | 1470314 | 252198 | SH |  | SOLE |  | 252198 | 0 | 0 |
| ASCENDIS PHARMA A/S | SPONSORED ADR | 04351P101 |  | 1458562 | 6840 | SH |  | SOLE |  | 6840 | 0 | 0 |
| ATYR PHARMA INC | COM NEW | 002120202 |  | 9241 | 11800 | SH | Put | SOLE |  | 11800 | 0 | 0 |
| ATYR PHARMA INC | COM NEW | 002120202 |  | 12138 | 15500 | SH | Call | SOLE |  | 15500 | 0 | 0 |
| AVIDITY BIOSCIENCES INC | COM | 05370A108 |  | 23658640 | 328000 | SH | Call | SOLE |  | 328000 | 0 | 0 |
| AYTU BIOPHARMA INC | COM | 054754858 |  | 795049 | 305788 | SH |  | SOLE |  | 305788 | 0 | 0 |
| BEONE MEDICINES LTD | SPONSORED ADS | 07725L102 |  | 172784 | 7500 | SH |  | SOLE |  | 7500 | 0 | 0 |
| BIOAGE LABS INC | COM | 09077V100 |  | 3587500 | 271164 | SH |  | SOLE |  | 271164 | 0 | 0 |
| BIOAGE LABS INC | COM | 09077V100 |  | 298998 | 22600 | SH | Call | SOLE |  | 22600 | 0 | 0 |
| BIOCRYST PHARMACEUTICALS INC | COM | 09058V103 |  | 1489238 | 190928 | SH |  | SOLE |  | 190928 | 0 | 0 |
| BIOHAVEN LTD | COM | G1110E107 |  | 2258000 | 200000 | SH | Call | SOLE |  | 200000 | 0 | 0 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 |  | 8698234 | 146361 | SH |  | SOLE |  | 146361 | 0 | 0 |
| BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 |  | 462672 | 190400 | SH | Call | SOLE |  | 190400 | 0 | 0 |
| BRIDGEBIO PHARMA INC | COM | 10806X102 |  | 5354300 | 70000 | SH |  | SOLE |  | 70000 | 0 | 0 |
| BRIDGEBIO PHARMA INC | COM | 10806X102 |  | 10678004 | 139600 | SH | Call | SOLE |  | 139600 | 0 | 0 |
| BRIDGEBIO PHARMA INC | COM | 10806X102 |  | 15298000 | 200000 | SH | Put | SOLE |  | 200000 | 0 | 0 |
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 |  | 4562045 | 158075 | SH |  | SOLE |  | 158075 | 0 | 0 |
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 |  | 5772000 | 200000 | SH | Put | SOLE |  | 200000 | 0 | 0 |
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 |  | 9012978 | 312300 | SH | Call | SOLE |  | 312300 | 0 | 0 |
| CASSAVA SCIENCES INC | COM | 14817C107 |  | 20988 | 10600 | SH | Put | SOLE |  | 10600 | 0 | 0 |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 |  | 2250900 | 90000 | SH |  | SOLE |  | 90000 | 0 | 0 |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 |  | 527711 | 21100 | SH | Call | SOLE |  | 21100 | 0 | 0 |
| COGENT BIOSCIENCES INC | COM | 19240Q201 |  | 4683383 | 131852 | SH |  | SOLE |  | 131852 | 0 | 0 |
| CORCEPT THERAPEUTICS INC | COM | 218352102 |  | 3391086 | 97445 | SH |  | SOLE |  | 97445 | 0 | 0 |
| CORCEPT THERAPEUTICS INC | COM | 218352102 |  | 4691040 | 134800 | SH | Put | SOLE |  | 134800 | 0 | 0 |
| CORMEDIX INC | COM | 21900C308 |  | 1849170 | 159000 | SH | Put | SOLE |  | 159000 | 0 | 0 |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 |  | 408870 | 53100 | SH | Put | SOLE |  | 53100 | 0 | 0 |
| CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 |  | 5909988 | 112700 | SH | Call | SOLE |  | 112700 | 0 | 0 |
| DESIGN THERAPEUTICS INC | COM | 25056L103 |  | 941002 | 100320 | SH |  | SOLE |  | 100320 | 0 | 0 |
| EDESA BIOTECH INC | COM NEW | 27966L306 |  | 76716 | 54025 | SH |  | SOLE |  | 54025 | 0 | 0 |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 |  | 744450 | 30000 | SH |  | SOLE |  | 30000 | 0 | 0 |
| EDITAS MEDICINE INC | COM | 28106W103 |  | 653335 | 318700 | SH | Call | SOLE |  | 318700 | 0 | 0 |
| ELI LILLY  CO | COM | 532457108 |  | 2149360 | 2000 | SH |  | SOLE |  | 2000 | 0 | 0 |
| ENANTA PHARMACEUTICALS INC | COM | 29251M106 |  | 1027226 | 65138 | SH |  | SOLE |  | 65138 | 0 | 0 |
| EQUILLIUM INC | COM | 29446K106 |  | 538459 | 347393 | SH |  | SOLE |  | 347393 | 0 | 0 |
| EVOLUS INC | COM | 30052C107 |  | 790020 | 118800 | SH | Call | SOLE |  | 118800 | 0 | 0 |
| FOGHORN THERAPEUTICS INC | COM | 344174107 |  | 165402 | 30630 | SH |  | SOLE |  | 30630 | 0 | 0 |
| GOSSAMER BIO INC | COM | 38341P102 |  | 2719010 | 877100 | SH | Call | SOLE |  | 877100 | 0 | 0 |
| HARMONY BIOSCIENCES HLDGS IN | COM | 413197104 |  | 280650 | 7500 | SH |  | SOLE |  | 7500 | 0 | 0 |
| IMMUNOCORE HLDGS PLC | ADS | 45258D105 |  | 2440113 | 70300 | SH |  | SOLE |  | 70300 | 0 | 0 |
| IMMUNOME INC | COM | 45257U108 |  | 483300 | 22500 | SH |  | SOLE |  | 22500 | 0 | 0 |
| INCYTE CORP | COM | 45337C102 |  | 9877000 | 100000 | SH | Put | SOLE |  | 100000 | 0 | 0 |
| INDIVIOR PLC | ORD | G4766E116 |  | 621442 | 17320 | SH |  | SOLE |  | 17320 | 0 | 0 |
| INDIVIOR PLC | ORD | G4766E116 |  | 7904364 | 220300 | SH | Call | SOLE |  | 220300 | 0 | 0 |
| INHIBRX BIOSCIENCES INC | COM | 45720N103 |  | 102621 | 1299 | SH |  | SOLE |  | 1299 | 0 | 0 |
| INOVIO PHARMACEUTICALS INC | COM SHS | 45773H409 |  | 928607 | 533682 | SH |  | SOLE |  | 533682 | 0 | 0 |
| INOVIO PHARMACEUTICALS INC | COM SHS | 45773H409 |  | 174000 | 100000 | SH | Call | SOLE |  | 100000 | 0 | 0 |
| INSMED INC | COM PAR $.01 | 457669307 |  | 9189312 | 52800 | SH | Call | SOLE |  | 52800 | 0 | 0 |
| INTELLIA THERAPEUTICS INC | COM | 45826J105 |  | 1909476 | 212400 | SH | Call | SOLE |  | 212400 | 0 | 0 |
| INTELLIA THERAPEUTICS INC | COM | 45826J105 |  | 2848931 | 316900 | SH | Put | SOLE |  | 316900 | 0 | 0 |
| INVENTIVA SA | ADS | 46124U107 |  | 1554267 | 334251 | SH |  | SOLE |  | 334251 | 0 | 0 |
| INVESCO QQQ TR | UNIT SER 1 | 46090E103 |  | 18429300 | 30000 | SH | Put | SOLE |  | 30000 | 0 | 0 |
| IONIS PHARMACEUTICALS INC | COM | 462222100 |  | 8401482 | 106200 | SH | Call | SOLE |  | 106200 | 0 | 0 |
| IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 |  | 2303769 | 683611 | SH |  | SOLE |  | 683611 | 0 | 0 |
| JADE BIOSCIENCES INC | COM NEW | 008064206 |  | 2972 | 1046 | SH | Put | SOLE |  | 1046 | 0 | 0 |
| JANUX THERAPEUTICS INC | COM | 47103J105 |  | 414000 | 30000 | SH | Call | SOLE |  | 30000 | 0 | 0 |
| JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 |  | 17901000 | 105300 | SH | Call | SOLE |  | 105300 | 0 | 0 |
| JOHNSON  JOHNSON | COM | 478160104 |  | 13750586 | 66444 | SH |  | SOLE |  | 66444 | 0 | 0 |
| JOHNSON  JOHNSON | COM | 478160104 |  | 10347500 | 50000 | SH | Call | SOLE |  | 50000 | 0 | 0 |
| KODIAK SCIENCES INC | COM | 50015M109 |  | 827616 | 29600 | SH | Call | SOLE |  | 29600 | 0 | 0 |
| LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 |  | 1500060 | 69000 | SH | Call | SOLE |  | 69000 | 0 | 0 |
| LIGAND PHARMACEUTICALS INC | COM NEW | 53220K504 |  | 564752 | 2987 | SH |  | SOLE |  | 2987 | 0 | 0 |
| LIPOCINE INC NEW | COM NEW | 53630X203 |  | 2095340 | 260939 | SH |  | SOLE |  | 260939 | 0 | 0 |
| LIQUIDIA CORPORATION | COM NEW | 53635D202 |  | 754676 | 21881 | SH |  | SOLE |  | 21881 | 0 | 0 |
| LYELL IMMUNOPHARMA INC | COM NEW | 55083R203 |  | 116964 | 3800 | SH | Put | SOLE |  | 3800 | 0 | 0 |
| MANNKIND CORP | COM NEW | 56400P706 |  | 1712340 | 302000 | SH |  | SOLE |  | 302000 | 0 | 0 |
| MANNKIND CORP | COM NEW | 56400P706 |  | 3131541 | 552300 | SH | Call | SOLE |  | 552300 | 0 | 0 |
| MAPLIGHT THERAPEUTICS INC | COM | 56565P103 |  | 1120489 | 63791 | SH |  | SOLE |  | 63791 | 0 | 0 |
| MEREO BIOPHARMA GROUP PLC | SPON ADS | 589492107 |  | 833192 | 1999500 | SH | Call | SOLE |  | 1999500 | 0 | 0 |
| MINERALYS THERAPEUTICS INC | COM | 603170101 |  | 907250 | 25000 | SH |  | SOLE |  | 25000 | 0 | 0 |
| MONTE ROSA THERAPEUTICS INC | COM | 61225M102 |  | 976566 | 62281 | SH |  | SOLE |  | 62281 | 0 | 0 |
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 |  | 622096 | 47200 | SH | Call | SOLE |  | 47200 | 0 | 0 |
| NEUPHORIA THERAPEUTICS INC | COM | 64136E102 |  | 194000 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| NOVO-NORDISK A S | ADR | 670100205 |  | 2701728 | 53100 | SH | Put | SOLE |  | 53100 | 0 | 0 |
| OCULAR THERAPEUTIX INC | COM | 67576A100 |  | 6618728 | 545200 | SH | Call | SOLE |  | 545200 | 0 | 0 |
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 |  | 2402500 | 96100 | SH | Call | SOLE |  | 96100 | 0 | 0 |
| PACIRA BIOSCIENCES INC | COM | 695127100 |  | 1242887 | 48025 | SH |  | SOLE |  | 48025 | 0 | 0 |
| PALISADE BIO INC | COM | 696389402 |  | 390215 | 166049 | SH |  | SOLE |  | 166049 | 0 | 0 |
| PELTHOS THERAPEUTICS INC | COM SHS | 171126204 |  | 775000 | 25000 | SH |  | SOLE |  | 25000 | 0 | 0 |
| PLIANT THERAPEUTICS INC | COM | 729139105 |  | 176795 | 144914 | SH |  | SOLE |  | 144914 | 0 | 0 |
| PRAXIS PRECISION MEDICINES I | COM NEW | 74006W207 |  | 29650844 | 100600 | SH | Put | SOLE |  | 100600 | 0 | 0 |
| PROQR THRAPEUTICS N V | SHS EURO | N71542109 |  | 338415 | 167532 | SH |  | SOLE |  | 167532 | 0 | 0 |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 |  | 1982618 | 22700 | SH |  | SOLE |  | 22700 | 0 | 0 |
| PROTHENA CORP PLC | SHS | G72800108 |  | 1017447 | 106539 | SH |  | SOLE |  | 106539 | 0 | 0 |
| PUMA BIOTECHNOLOGY INC | COM | 74587V107 |  | 201110 | 33800 | SH | Call | SOLE |  | 33800 | 0 | 0 |
| PURETECH HEALTH PLC | ADS | 746237106 |  | 123835 | 7442 | SH |  | SOLE |  | 7442 | 0 | 0 |
| RECURSION PHARMACEUTICALS IN | CL A | 75629V104 |  | 3034371 | 741900 | SH | Call | SOLE |  | 741900 | 0 | 0 |
| REGENERON PHARMACEUTICALS | COM | 75886F107 |  | 7950261 | 10300 | SH |  | SOLE |  | 10300 | 0 | 0 |
| REGENERON PHARMACEUTICALS | COM | 75886F107 |  | 3859350 | 5000 | SH | Call | SOLE |  | 5000 | 0 | 0 |
| RELMADA THERAPEUTICS INC | COM | 75955J402 |  | 1880778 | 389395 | SH |  | SOLE |  | 389395 | 0 | 0 |
| REPLIMUNE GROUP INC | COM | 76029N106 |  | 2245291 | 230997 | SH |  | SOLE |  | 230997 | 0 | 0 |
| REVIVA PHARMACEUTCLS HLDGS I | COM | 76152G100 |  | 139500 | 500000 | SH | Call | SOLE |  | 500000 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 2948643 | 37020 | SH |  | SOLE |  | 37020 | 0 | 0 |
| RIGEL PHARMACEUTICALS INC | COM | 766559702 |  | 1284900 | 30000 | SH |  | SOLE |  | 30000 | 0 | 0 |
| ROIVANT SCIENCES LTD | SHS | G76279101 |  | 6915790 | 318700 | SH | Put | SOLE |  | 318700 | 0 | 0 |
| SELLAS LIFE SCIENCES GROUP I | COM NEW | 81642T209 |  | 1601873 | 424900 | SH | Call | SOLE |  | 424900 | 0 | 0 |
| SOLENO THERAPEUTICS INC | COM | 834203309 |  | 1245100 | 26892 | SH |  | SOLE |  | 26892 | 0 | 0 |
| SOLENO THERAPEUTICS INC | COM | 834203309 |  | 2458530 | 53100 | SH | Call | SOLE |  | 53100 | 0 | 0 |
| SPDR SERIES TRUST | STATE STREET SPD | 78464A870 |  | 30482500 | 250000 | SH | Put | SOLE |  | 250000 | 0 | 0 |
| STOKE THERAPEUTICS INC | COM | 86150R107 |  | 545325 | 17181 | SH |  | SOLE |  | 17181 | 0 | 0 |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 |  | 13332735 | 191700 | SH | Call | SOLE |  | 191700 | 0 | 0 |
| TALPHERA INC | COM NEW | 00444T209 |  | 156092 | 136923 | SH |  | SOLE |  | 136923 | 0 | 0 |
| TECTONIC THERAPEUTIC INC | COM | 878972108 |  | 2098516 | 100600 | SH | Call | SOLE |  | 100600 | 0 | 0 |
| TENAX THERAPEUTICS INC | COM NEW | 88032L605 |  | 2964242 | 243170 | SH |  | SOLE |  | 243170 | 0 | 0 |
| TERNS PHARMACEUTICALS INC | COM | 880881107 |  | 13973552 | 345880 | SH |  | SOLE |  | 345880 | 0 | 0 |
| TERNS PHARMACEUTICALS INC | COM | 880881107 |  | 2613880 | 64700 | SH | Call | SOLE |  | 64700 | 0 | 0 |
| TG THERAPEUTICS INC | COM | 88322Q108 |  | 3675066 | 123283 | SH |  | SOLE |  | 123283 | 0 | 0 |
| TG THERAPEUTICS INC | COM | 88322Q108 |  | 2981000 | 100000 | SH | Put | SOLE |  | 100000 | 0 | 0 |
| TRAVERE THERAPEUTICS INC | COM | 89422G107 |  | 1921963 | 50300 | SH | Put | SOLE |  | 50300 | 0 | 0 |
| TREVI THERAPEUTICS INC | COM | 89532M101 |  | 1216744 | 97184 | SH |  | SOLE |  | 97184 | 0 | 0 |
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 |  | 2300000 | 100000 | SH | Call | SOLE |  | 100000 | 0 | 0 |
| UNIQURE NV | SHS | N90064101 |  | 1076850 | 45000 | SH |  | SOLE |  | 45000 | 0 | 0 |
| UNIQURE NV | SHS | N90064101 |  | 7222074 | 301800 | SH | Put | SOLE |  | 301800 | 0 | 0 |
| UNITED THERAPEUTICS CORP DEL | COM | 91307C102 |  | 4872500 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| UPSTREAM BIO INC | COM | 91678A107 |  | 556575 | 20500 | SH |  | SOLE |  | 20500 | 0 | 0 |
| UROGEN PHARMA LTD | COM | M96088105 |  | 510790 | 21810 | SH |  | SOLE |  | 21810 | 0 | 0 |
| VANDA PHARMACEUTICALS INC | COM | 921659108 |  | 1764000 | 200000 | SH | Call | SOLE |  | 200000 | 0 | 0 |
| VAXCYTE INC | COM | 92243G108 |  | 1059928 | 22972 | SH |  | SOLE |  | 22972 | 0 | 0 |
| VENTYX BIOSCIENCES INC | COM | 92332V107 |  | 1806000 | 200000 | SH |  | SOLE |  | 200000 | 0 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 |  | 4533600 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 |  | 40031688 | 88300 | SH | Call | SOLE |  | 88300 | 0 | 0 |
| VIKING THERAPEUTICS INC | COM | 92686J106 |  | 11850348 | 336849 | SH |  | SOLE |  | 336849 | 0 | 0 |
| VIKING THERAPEUTICS INC | COM | 92686J106 |  | 11141506 | 316700 | SH | Put | SOLE |  | 316700 | 0 | 0 |
| VIKING THERAPEUTICS INC | COM | 92686J106 |  | 24235502 | 688900 | SH | Call | SOLE |  | 688900 | 0 | 0 |
| VIR BIOTECHNOLOGY INC | COM | 92764N102 |  | 603000 | 100000 | SH |  | SOLE |  | 100000 | 0 | 0 |
| VIR BIOTECHNOLOGY INC | COM | 92764N102 |  | 537876 | 89200 | SH | Call | SOLE |  | 89200 | 0 | 0 |
| VIRIDIAN THERAPEUTICS INC | COM | 92790C104 |  | 657068 | 21114 | SH |  | SOLE |  | 21114 | 0 | 0 |
| VISTAGEN THERAPEUTICS INC | COM | 92840H400 |  | 66190 | 100000 | SH |  | SOLE |  | 100000 | 0 | 0 |
| VISTAGEN THERAPEUTICS INC | COM | 92840H400 |  | 70492 | 106500 | SH | Call | SOLE |  | 106500 | 0 | 0 |
| XERIS BIOPHARMA HOLDINGS INC | COM | 98422E103 |  | 1338959 | 170568 | SH |  | SOLE |  | 170568 | 0 | 0 |
| ZYMEWORKS INC | COM | 98985Y108 |  | 6334998 | 240600 | SH | Call | SOLE |  | 240600 | 0 | 0 |
| ZYMEWORKS INC | COM | 98985Y108 |  | 563462 | 21400 | SH | Put | SOLE |  | 21400 | 0 | 0 |

---