# EDGAR Filing Document

**Accession Number:** 0000901832
**File Stem:** 0001104659-26-009284
**Filing Date:** 2026-2
**Character Count:** 457692
**Document Hash:** 0c39c1b44496a151a53d4c0280119dbb
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-26-009284.hdr.sgml**: 20260203

**ACCESSION NUMBER**: 0001104659-26-009284

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 22

**FILED AS OF DATE**: 20260202

**DATE AS OF CHANGE**: 20260203

**EFFECTIVENESS DATE**: 20260202

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** ASTRAZENECA PLC
- **CENTRAL INDEX KEY:** 0000901832
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** X0
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-293157
- **FILM NUMBER:** 26592318

**BUSINESS ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** 1 FRANCIS CRICK AVENUE
- **STREET 2:** CAMBRIDGE BIOMEDICAL CAMPUS
- **CITY:** CAMBRIDGE
- **PROVINCE COUNTRY:** X0
- **ZIP:** CB2 0AA
- **BUSINESS PHONE:** 011 44 20 7304 5000

**MAIL ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** 1 FRANCIS CRICK AVENUE
- **STREET 2:** CAMBRIDGE BIOMEDICAL CAMPUS
- **CITY:** CAMBRIDGE
- **PROVINCE COUNTRY:** X0
- **ZIP:** CB2 0AA

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ZENECA GROUP PLC
- **DATE OF NAME CHANGE:** 19930422

**As filed with the Securities and Exchange Commission on February 2, 2026**

**Registration No. 333-** 

**UNITED STATES SECURITIES AND EXCHANGE<br> COMMISSION**

**Washington, D.C. 20549**

**FORM S-8**

**REGISTRATION STATEMENT<br> Under<br> THE SECURITIES ACT OF 1933**

**ASTRAZENECA PLC**<br> (Exact name of registrant as specified in its charter)

---

| | |
|:---|:---|
| **England and Wales**<br> (State or other jurisdiction of incorporation or<br> organization) | **Not Applicable**<br> (I.R.S. Employer Identification No.) |
| <br> **1 Francis Crick Avenue<br> Cambridge Biomedical Campus<br> Cambridge CB2 0AA<br> England**<br> (Address of principal executive offices)  | <br> **1 Francis Crick Avenue<br> Cambridge Biomedical Campus<br> Cambridge CB2 0AA<br> England**<br> (Address of principal executive offices)  |

---

**ASTRAZENECA RESTRICTED SHARE PLAN**

**ASTRAZENECA GLOBAL RESTRICTED STOCK PLAN**

**ASTRAZENECA EXTENDED INCENTIVE PLAN**

**ASTRAZENECA DEFERRED BONUS PLAN**

**ASTRAZENECA PERFORMANCE SHARE PLAN 2020**

**ASTRAZENECA SAVINGS RELATED SHARE OPTION SCHEME**

**ASTRAZENECA SHARE INCENTIVE PLAN**

**ASTRAZENECA SHAREPLUS PLAN**<br> (Full title of the plan)

**CT Corporation System<br> 28 Liberty Street<br> New York, NY 10005<br> Tel: +1-212-894-8940**<br> (Name, address and telephone number of agent for service)

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act. (Check one)

⌧ Large accelerated filer ◻ Accelerated filer ◻ Non-accelerated filer ◻ Smaller reporting company <br> ◻ Emerging growth company

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ◻

**EXPLANATORY NOTE**

This Registration Statement on Form S-8 (this "<u>Registration Statement</u>") registers (i) 1,086,071 Ordinary Shares, par value $0.25 each ("<u>Ordinary Shares</u>"), of AstraZeneca PLC (the "<u>Company</u>" or the "<u>Registrant</u>") that may be offered or sold upon exercise of outstanding options previously granted under the AstraZeneca Savings Related Share Option Scheme and (ii) 25,865,874 Ordinary Shares that may be offered or sold, in connection with the AstraZeneca Restricted Share Plan, AstraZeneca Global Restricted Stock Plan, AstraZeneca Extended Incentive Plan, AstraZeneca Deferred Bonus Plan, AstraZeneca Performance Share Plan 2020, AstraZeneca Savings Related Share Option Scheme, AstraZeneca Share Incentive Plan and the AstraZeneca SharePlus Plan (the "<u>Plans</u>").

**PART I**

The information specified in Item 1 and Item 2 of Part I of this Registration Statement is omitted from this filing in accordance with the provisions of Rule 428 under the Securities Act of 1933, as amended (the "<u>Securities Act</u>"). The documents containing the information specified in Part I will be delivered to the participants in the Plans covered by this Registration Statement as required by Rule 428(b)(1).

**PART II**

**INFORMATION REQUIRED IN THE REGISTRATION STATEMENT**

**Item 3. Incorporation of Documents by Reference.**

The following documents and information previously filed with the U.S. Securities and Exchange Commission (the "<u>Commission</u>") by the Company are incorporated herein by reference:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) The Company's [Annual Report on Form 20-F for the fiscal year ended December 31, 2024 (File No. 001-11960), filed with the Commission on February 18, 2025](https://www.sec.gov/ix?doc=/Archives/edgar/data/901832/000110465925014750/azn-20241231x20f.htm) .

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) The Company's Current Reports on [Form 6-K filed with the Commission on February 18, 2025](https://www.sec.gov/Archives/edgar/data/901832/000165495425001614/a4044x.htm) .

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) The description of the Company's Ordinary Shares contained in the Company's registration statement
on [Form 8-A (File No. 001-11960), filed with the Commission on January 22, 2026](https://www.sec.gov/Archives/edgar/data/901832/000110465926005772/tm263731d1_8a12b.htm) , including any amendment or report filed
for the purpose of updating such description.

In addition, all documents filed by the Company pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, as amended (the "<u>Exchange Act</u>"), and, to the extent, if any, the Company designates therein, reports on Form 6-K the Company furnishes to the Commission on or after the date of this Registration Statement, but prior to the filing of a post-effective amendment which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference in this Registration Statement and to be a part hereof from the date of filing of such documents.

Each document incorporated by reference is current only as of the date of such document, and the incorporation by reference of such document shall not create any implication that there has been no change in the affairs of the Company since its date thereof or that the information contained in it is current as of any time subsequent to its date. Any statement contained in this Registration Statement or in a document incorporated by reference in this Registration Statement shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a subsequent statement contained in this Registration Statement or in any subsequently filed document that is deemed to be incorporated by reference in this Registration Statement modifies or supersedes such statement.

**Item 4. Description of Securities.**

Not applicable.

**Item 5. Interests of Named Experts and Counsel.**

Sebastian Kramer, who is issuing the opinion on the legality of the securities offered hereby, is an Assistant General Counsel of the Registrant and holds Ordinary Shares and unvested share awards of the Registrant. Sebastian Kramer is eligible to participate in the AstraZeneca Global Restricted Stock Plan.

**Item 6. Indemnification of Directors and Officers.**

*Deeds of Indemnity*

The Company has entered into Deeds of Indemnity with the directors of the Company that provide that, subject to certain conditions precedent and limitations, in consideration for such director or officer continuing in, or accepting, office as a director or officer of (i) the Company or (ii) any of the Company's subsidiaries, the Company will indemnify and hold the director harmless in respect of all (a) claims, actions and proceedings and (b) losses, damages, penalties, liabilities, compensation or other awards, or any settlement thereof to which the Company consents, arising in connection with any claims, actions or proceedings (whether instigated, imposed, incurred or settled under the laws of any jurisdiction) for negligence, default, breach of duty, breach of trust or otherwise, arising out of, or in connection with, the actual or purported exercise of, or failure to exercise any of the director's powers, duties or responsibilities as a director or officer of the Company or any of its subsidiaries or which otherwise arises by virtue of the director holding or having held such a position.

*Article 97.2 of the Articles of Association of the Company provides:*

"Without prejudice to the provisions of Article 140, the board may exercise all the powers of the Company to purchase and maintain insurance for or for the benefit of any person who is or was:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) a director, officer, or employee of the Company, or any body which is or was the holding company or subsidiary undertaking of the Company, or in which the Company or such holding company or subsidiary undertaking has or had any interest (whether direct or indirect) or with which the Company or such holding company or subsidiary undertaking is or was in any way allied or associated; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) a trustee of any pension fund in which employees of the Company or any other body referred to in Article 97.2(a) are or have been interested,

including, without limitation, insurance against any liability incurred by such person in respect of any act or omission in the actual or purported execution or discharge of that person's duties or in the exercise or purported exercise of that person's powers or otherwise in relation to that person's duties, powers or offices in relation to the relevant body or fund."

*Article 140 of the Articles of Association of the Company provides:*

"Subject to the provisions of the Companies Acts, but without prejudice to any indemnity to which the person concerned may otherwise be entitled, every director or other officer of the Company (other than any person (whether an officer or not) engaged by the Company as auditor) shall be indemnified out of the assets of the Company against any liability incurred by such director or other officer for negligence, default, breach of duty or breach of trust in relation to the affairs of the Company, provided that this Article shall be deemed not to provide for, or entitle any such person to, indemnification to the extent that it would cause this Article, or any element of it, to be treated as void under the Act or otherwise under the Companies Acts."

*Section 232 of the Companies Act 2006 provides:*

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) Any provision that purports to exempt a director of a company (to any extent) from any liability that would otherwise attach to him in connection with any negligence, default, breach of duty or breach of trust in relation to the company is void.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) Any provision by which a company directly or indirectly provides an indemnity (to any extent) for a director of the company, or of an associated company, against any liability attaching to him in connection with any negligence, default, breach of duty or breach of trust in relation to the company of which he is a director is void, except as permitted by—

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) section 233 (provision of insurance),

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) section 234 (qualifying third party indemnity provision), or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) section 235 (qualifying pension scheme indemnity provision).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3) This section applies to any provision, whether contained in a company's articles or in any contract with the company or otherwise.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(4) Nothing in this section prevents a company's articles from making such provision as has previously been lawful for dealing with conflicts of interest."

*Section 234 of the Companies Act 2006 provides:*

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) Section 232(2) (voidness of provisions for indemnifying directors) does not apply to qualifying third party indemnity provision.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) Third party indemnity provision means provision for indemnity against liability incurred by the director to a person other than the company or an associated company.

Such provision is qualifying third party indemnity provision if the following requirements are met.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3) The provision must not provide any indemnity against—

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) any liability of the director to pay—

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) a fine imposed in criminal proceedings, or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) a sum payable to a regulatory authority by way of a penalty in respect of non-compliance with any requirement of a regulatory nature (however arising); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) any liability incurred by the director—

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) in defending criminal proceedings in which he is convicted, or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) in defending civil proceedings brought by the company, or an associated company, in which judgment is given against him, or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) in connection with an application for relief (see subsection (6)) in which the court refuses to grant him relief.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(4) The references in subsection (3)(b) to a conviction, judgment or refusal of relief are to the final decision in the proceedings.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(5) For this purpose—

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) a conviction, judgment or refusal of relief becomes final—

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) if not appealed against, at the end of the period for bringing an appeal, or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) if appealed against, at the time when the appeal (or any further appeal) is disposed of; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) an appeal is disposed of—

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) if it is determined and the period for bringing any further appeal has ended, or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) if it is abandoned or otherwise ceases to have effect.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(6) The reference in subsection (3)(b)(iii) to an application for relief is to an application for relief under—

section 661(3) or (4) (power of court to grant relief in case of acquisition of shares by innocent nominee), or

section 1157 (general power of court to grant relief in case of honest and reasonable conduct).

*Section 1157 of the Companies Act 2006 provides:*

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) If in proceedings for negligence, default, breach of duty or breach of trust against—

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) an officer of a company, or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) a person employed by a company as auditor (whether he is or is not an officer of the company),

it appears to the court hearing the case that the officer or person is or may be liable but that he acted honestly and reasonably, and that having regard to all the circumstances of the case (including those connected with his appointment) he ought fairly to be excused, the court may relieve him, either wholly or in part, from his liability on such terms as it thinks fit.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) If any such officer or person has reason to apprehend that a claim will or might be made against him in respect of negligence, default, breach of duty or breach of trust—

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) he may apply to the court for relief, and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the court has the same power to relieve him as it would have had if it had been a court before which proceedings against him for negligence, default, breach of duty or breach of trust had been brought.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3) Where a case to which subsection (1) applies is being tried by a judge with a jury, the judge, after hearing the evidence, may, if he is satisfied that the defendant (in Scotland, the defender) ought in pursuance of that subsection to be relieved either in whole or in part from the liability sought to be enforced against him, withdraw the case from the jury and forthwith direct judgment to be entered for the defendant (in Scotland, grant decree of absolvitor) on such terms as to costs (in Scotland, expenses) or otherwise as the judge may think proper."

The Company maintains directors' and officers' liability insurance which, subject to policy terms and limitations, provides insurance cover against the personal liabilities which directors and officers may incur by reason of their duties. The authorized representative is also entitled to the benefit of the same directors' and officers' liability insurance.

**Item 7. Exemption from Registration Claimed.**

Not applicable.

**Item 8. Exhibits.**

---

| | |
|:---|:---|
| **Exhibit<br> No.** | **Description** |
| [4.1](https://www.sec.gov/Archives/edgar/data/901832/000110465925105425/tm2529889d1_ex99-1.htm) | [Articles of Association (incorporated herein by reference to Exhibit 99.1 to Form 6-K filed by the Company on November 3, 2025).](https://www.sec.gov/Archives/edgar/data/901832/000110465925105425/tm2529889d1_ex99-1.htm) |
| [4.2](tm264269d1_ex4-2.htm) | [AstraZeneca Restricted Share Plan.\*](tm264269d1_ex4-2.htm) |
| [4.3](tm264269d1_ex4-3.htm) | [AstraZeneca Global Restricted Stock Plan.\*](tm264269d1_ex4-3.htm) |
| [4.4](tm264269d1_ex4-4.htm) | [AstraZeneca Extended Incentive Plan.\*](tm264269d1_ex4-4.htm) |
| [4.5](tm264269d1_ex4-5.htm) | [AstraZeneca Deferred Bonus Plan.\*](tm264269d1_ex4-5.htm) |
| [4.6](tm264269d1_ex4-6.htm) | [AstraZeneca Performance Share Plan 2020.\*](tm264269d1_ex4-6.htm) |
| [4.7](tm264269d1_ex4-7.htm) | [AstraZeneca Savings Related Share Option Scheme.\*](tm264269d1_ex4-7.htm) |
| [4.8](tm264269d1_ex4-8.htm) | [AstraZeneca Share Incentive Plan.\*](tm264269d1_ex4-8.htm) |
| [4.9](tm264269d1_ex4-9.htm) | [AstraZeneca SharePlus Plan.\*](tm264269d1_ex4-9.htm) |
| [5.1](tm264269d1_ex5-1.htm) | [Opinion of Sebastian Kramer\*](tm264269d1_ex5-1.htm) |
| [23.1](tm264269d1_ex23-1.htm) | [Consent of PricewaterhouseCoopers LLP, independent registered public accounting firm.\*](tm264269d1_ex23-1.htm) |
| [23.2](tm264269d1_ex5-1.htm) | [Consent of Sebastian Kramer (included in Exhibit 5.1).\*](tm264269d1_ex5-1.htm) |
| [24.1](#a_001) | [Power of Attorney (see signature page hereto).\*](#a_001) |
| [107](tm264269d1_ex-filingfees.htm) | [Filing Fee Table.\*](tm264269d1_ex-filingfees.htm) |

---

\* Filed herewith

**Item 9. Undertakings.**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) The undersigned Registrant hereby undertakes:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement: (i) to include any prospectus required by Section 10(a)(3) of the Securities Act; (ii) to reflect in the prospectus any facts or events arising after the effective date of the Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this Registration Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20% change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective Registration Statement; and (iii) to include any material information with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such information in the Registration Statement; *provided*, *however*, that the undertakings set forth in clauses (a)(1)(i) and (a)(1)(ii) above do not apply if the information required to be included in a post-effective amendment by those clauses is contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3) To remove from registration by means of a post-effective amendment any of the securities being registered that remain unsold at the termination of the offering.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference into the Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.

**SIGNATURES**

Pursuant to the requirements of the Securities Act, AstraZeneca PLC certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized in London on February 2, 2026.

---

| | |
|:---|:---|
| ASTRAZENECA PLC | ASTRAZENECA PLC |
| By: | /s/ Matthew Bowden |
|  | Name: Matthew Bowden |
|  | Title: Company Secretary |

---

**POWER OF ATTORNEY**

KNOW ALL PERSONS BY THESE PRESENTS that each person whose signature appears below hereby constitutes and appoints Matthew Bowden, Hannah Tattersall and Camilla Johnstone (with full power to each of them to act alone), as such person's true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for such person and in such person's name, place and stead, in any and all capacities, to sign and file with the Securities and Exchange Commission any and all amendments and post-effective amendments to this Registration Statement, with exhibits thereto and any and all other documents that may be required in connection therewith, granting unto each said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as might or could do in person, hereby ratifying and confirming all that each said attorney-in-fact and agent, or any substitutes therefor, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed below by the following persons in the capacities and on the dates indicated.

---

| | | |
|:---|:---|:---|
| **Name** | **Title** | **Date** |
| /s/ Pascal Soriot | Executive Director and Chief Executive Officer | February 2, 2026 |
| Pascal Soriot | (Principal Executive Officer) |  |
| /s/ Aradhana Sarin | Executive Director and Chief Financial Officer | February 2, 2026 |
| Aradhana Sarin | (Principal Financial Officer) |  |
| /s/ Mani Sharma | SVP, Group Controller and Head of Global Finance Services | February 2, 2026 |
| Mani Sharma | (Principal Accounting Officer) |  |
| /s/ Michel Demaré | Non-Executive Chair of the Board | February 2, 2026 |
| Michel Demaré |  |  |
| /s/ Philip Broadley | Senior Independent Non-Executive Director | February 2, 2026 |
| Philip Broadley |  |  |
| /s/ Euan Ashley | Non-Executive Director | February 2, 2026 |
| Euan Ashley |  |  |
| /s/ Birgit Conix | Non-Executive Director | February 2, 2026 |
| Birgit Conix |  |  |

---

---

| | | |
|:---|:---|:---|
| /s/ Rene Haas | Non-Executive Director | February 2, 2026 |
| Rene Haas |  |  |
| /s/ Karen Knudsen | Non-Executive Director | February 2, 2026 |
| Karen Knudsen |  |  |
|  | Non-Executive Director |  |
| Diana Layfield |  |  |
| /s/ Anna Manz | Non-Executive Director | February 2, 2026 |
| Anna Manz |  |  |
| /s/ Sheri McCoy | Non-Executive Director | February 2, 2026 |
| Sheri McCoy |  |  |
| /s/ Tony Mok | Non-Executive Director | February 2, 2026 |
| Tony Mok |  |  |
| /s/ Nazneen Rahman | Non-Executive Director | February 2, 2026 |
| Nazneen Rahman |  |  |
| /s/ Marcus Wallenberg | Non-Executive Director | February 2, 2026 |
| Marcus Wallenberg |  |  |

---

---

| | |
|:---|:---|
| Authorized Representative |  |
| /s/ Mariam Koohdary | February 2, 2026 |
| Mariam Koohdary, as duly authorized representative of AstraZeneca PLC in the United States |  |

---

## Exhibit 4.2

**Exhibit 4.2**

Plan Rules of the AstraZeneca Restricted Share Plan

Adopted by RemCo on 13 December 2023 and amended on 3 February 2025 and 11 December 2025.<br> Plan terminates on 13 December 2033.<br> French Appendix expires 13 April 2030

**AstraZeneca Restricted Share Plan**

*<u>What is an award and when do you get shares?</u>*

An award under the Plan is a contingent right to receive shares in AstraZeneca PLC. When your award 'vests' you receive shares.

Your award will normally vest a specified number of years after grant. After your award vests, you will receive a net number of shares after withholdings for tax have been made. Your shares will be transferred into a nominee or custodian arrangement for you.

*<u>What happens if you leave?</u>*

Awards will generally only vest if you are employed. If you leave AZ within the specified number of years after grant, your unvested awards will normally lapse.

However, if you end employment for one of the following reasons:

(a) death,

(b) ill-health, injury or disability (in each case evidenced to the satisfaction of your employer),

(c) redundancy (within the terms of the Employment Rights Act 1996),

(d) circumstances determined by RemCo to be retirement, or

(e) the company or business in which you are employed ceasing to be a member of the AZ group,

and your award was granted at the time of your recruitment to the AZ Group as a sign-on award, or in compensation for any awards or bonuses forfeited at your previous employer,

your award will not lapse and it will normally vest on the date you cease employment, pro-rated for the time you were in employment.

*<u>Change of control of AstraZeneca</u>*

If there is a change in control of AZ, your award will vest pro-rata (subject to achievement of any performance targets).

*<u>Dividends</u>*

On vesting, you will receive cash or additional shares to reflect any dividends that would have been paid to you had you held the shares that vest on any dividend record dates during the Vesting Period (dividend equivalents).

*<u>General</u>*

Awards are personal to you and may not be transferred or charged until they vest. The awards do not form part of your terms and conditions of employment and are not pensionable.

You may be required to acknowledge the grant of your award and agree to certain terms.

This summary does not form part of the Rules of the RSP. The Rules of the RSP are set out in the following pages and will govern how your awards are treated. Definitions and interpretation provisions are at **‎Appendix 1**. If you are resident in a country outside of the UK, your award may be subject to special terms.

**Rules of the AstraZeneca Restricted Share Plan**

1. **Grant of Awards** 

RemCo may approve the grant of Awards to Eligible Employees, subject to the limits in **Rule** ‎**10**. Awards will not be granted during a Closed Period.

2. **Vesting of Awards** 

2.1 Vesting of your Award is subject to such terms and conditions as RemCo considers appropriate before grant.

2.2 Unless your Award vests early under **Rules** ‎ **3** or **‎** **7**, your Award will vest on the Vesting Date to the extent that any terms and conditions
imposed under **Rule** ‎ **2.1** have been met.

3. **End of Employment** 

3.1 If you end Employment before the Vesting Date other than in any of the circumstances set out in **Rule** ‎ **3.2**,
your Award will lapse unless RemCo in its absolute discretion decides otherwise, in which case RemCo has discretion to decide when and
to what extent your Award may vest.

3.2 If you end Employment before the Vesting Date for one of the following reasons:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.1 death;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.2 ill-health, injury or disability (in each case evidenced to the satisfaction of your employing company);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.3 redundancy within the terms of the Employment Rights Act 1996;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.4 circumstances determined by RemCo, or anyone authorised by RemCo, to be retirement; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.5 the company by which you are employed ceasing to be a member of the AZ Group, or the part of the business
in which you are employed being transferred to a person outside the AZ Group,

and, in AZ's opinion, your Award was granted at the time of your recruitment to the AZ Group as a sign-on award, or in compensation for any awards or bonuses forfeited at your previous employer, your Award will vest on the date you end Employment, and will be reduced pro-rata to the proportion of the Vesting Period that has elapsed up to the end of Employment, unless RemCo decides not to pro-rate or to pro-rate on some other basis.

3.3 For the purposes of this **Rule** ‎ **3,** if you are
on statutory family-related leave, you will not end Employment until the earlier of the date on which you notify your employer of your
intention not to return to work or the date on which you cease to have statutory or contractual rights to return to work.

3.4 If you are resident in China and you end Employment as a result of your death, if a delay in providing
the necessary documentation will result in a breach of the Chinese State Administration of Foreign Exchange requirements, your Award shall
not be satisfied by the issue or transfer of Shares but will be satisfied by the payment of a cash sum equal to the value of the Shares
in respect of which your Award vested under **Rule ‎ 3.2** (converted into your relevant
payroll currency at an appropriate spot rate) less deductions for Tax Liabilities.

4. **Lapse of Awards** 

4.1 Notwithstanding any other provision of these Rules, your Award will lapse:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.1.1 if you are declared bankrupt or are unable to hold your Award by operation of law, or you attempt to transfer,
assign, charge or dispose of your Award contrary to **Rule 12.2**;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.1.2 to the extent that: (i) the Award does not vest in full under **Rules** ‎ **3** or **‎** **7**; or (ii) the number of Shares which are subject to the Award is
reduced under **Rule** ‎ **8**.

5. **Consequences of Vesting of an Award** 

5.1 After vesting of your Award, the number of Shares in respect of which it has vested will, subject to **Rule** ‎ **6**,
be transferred to you as soon as practicable. Your Shares may be transferred into any nominee or other custodian arrangement as AZ shall
determine is appropriate (**Shareholding Arrangement**) and will be held on your behalf on the terms notified to you from time to time.

5.2 In the event that you end Employment, unless your Shares are required by AZ to be retained in the Shareholding
Arrangement, you will be required to remove your Shares from such Shareholding Arrangement within six months of the date you end Employment.
If your Shares remain in the Shareholding Arrangement at the end of that six month period, AZ will have the right, at any time, to sell
or direct the sale of your Shares on your behalf at the prevailing market rate and will remit the cash proceeds to you or to an account
with a nominee or custodian on your behalf. For the avoidance of doubt, Shares in this **Rule** ‎ **5.2** shall refer to Shares acquired on vesting of your Award, including pursuant to **Rule** ‎ **5.4**,
and any additional Shares that are acquired by you as a result of your holding of such Shares, for example by way of reinvestment of dividends
paid on such Shares.

5.3 You will have no voting, dividend or other rights in the Shares under your Award before the Vesting Date.
Shares that you acquire under the Plan will not have the benefit of any rights that attach to those Shares by reference to a record date
that is earlier than the date when you acquired them.

5.4 To the extent that your Award vests you may receive an additional amount as "dividend equivalents".
Unless RemCo decides otherwise, your dividend equivalents will be calculated by reference to the dividends paid or which are payable on
the number of Shares that vest, as if those dividends had been reinvested in Shares on the relevant dividend record dates during the Vesting
Period, or if your Award vests early, until the date of such vesting. This payment will be made in cash or Shares, subject to deductions
for Tax Liabilities, after your Award has vested, but no later than 15 March after the calendar year in which your Award has vested.

5.5 Notwithstanding any other provision, RemCo may, at any time, determine that your Award shall not be satisfied
by the issue or transfer of Shares but will be satisfied by the payment to you of a cash sum equal to the value of the Shares in respect
of which your Award vests on the day of vesting (converted into your relevant payroll currency at an appropriate spot rate) less deductions
for Tax Liabilities.

6. **Tax** 

By accepting the Award, you indemnify AZ and your employer against any Tax Liabilities that may arise in connection with the benefits delivered under the Plan. AZ or your employer may withhold any amount and make any arrangements it considers necessary to meet any Tax Liabilities, which may include the sale on your behalf of any Shares acquired by you under the Plan.

7. **Change of Control of AZ** 

7.1 If before the Vesting Date of an Award:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.1.1 an offeror (alone or with any party acting in concert with the offeror) obtains Control of AZ by making
an offer to acquire the whole of the issued ordinary share capital of AZ (or any part of it which is not owned by the offeror and any
party acting in concert with the offeror);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.1.2 the Court sanctions a compromise or arrangement affecting the Shares under section 899 of the Companies
Act 2006; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.1.3 a resolution is passed for the voluntary winding up of AZ,

unless **Rule** ‎**7.4** applies, your Award will vest on the date of that event, to the extent decided by RemCo under **Rule** ‎**7.2**.

7.2 Where **Rule** ‎ **7.1** applies or is likely to apply,
an Award will vest pro-rata to the time which has elapsed between the Date of Grant of the Award and the date of the relevant event (subject
to achievement of any applicable performance targets, in the opinion of RemCo, at the time of the relevant event or most practicable earlier
date). However, RemCo may decide to take into account any other factors it believes to be relevant in determining the extent to which
an Award will vest in circumstances it considers exceptional.

7.3 RemCo will confirm the extent (if any) to which an Award will vest under **Rule** ‎ **7.2**.
Confirmation may be before, but conditional on, the relevant event in **Rule** ‎ **7.1**.

7.4 If a company obtains Control of AZ, but the shareholders of the acquiring company immediately after it
has obtained Control of AZ are substantially the same as the shareholders of AZ immediately before that event, and if the acquiring company
consents to this **Rule** ‎ **7.4** applying, then your Award will not vest under **Rule** ‎ **7.1**.
Instead, it will be exchanged for a new award in respect of shares having a total Market Value being equal to the Market Value of the
Shares that are subject to your Award immediately before the exchange. The new award will be governed by the Rules, except that references
to Shares shall refer to shares in the acquiring company, and references to AZ shall refer to the acquiring company.

8. **Malus and Clawback** 

Notwithstanding any other provision, Awards are subject to the Malus and Clawback Global Standard and by accepting an Award, you agree to be bound by the terms of the Malus and Clawback Global Standard.

9. **Amending the Plan and Awards** 

9.1 If there is a Variation in the equity share capital of AZ, the number and/or the nominal value of the
Shares over which your Award is granted will be adjusted as RemCo decides. You will be notified of any adjustment under **Rule** ‎ **9.1**.

9.2 AZ can amend these Rules at any time.

9.3 AZ can adopt additional sections of these Rules applicable in any jurisdiction under which Awards
may be subject to additional and/or modified terms and conditions, taking into account any securities, exchange control or taxation laws,
which may apply to you, AZ, or any member of the AZ Group. Any additional sections must conform to the basic principles of the Plan and
must not exceed the limits set out in these Rules.

10. **Limit on the number of Shares which can be issued** 

10.1 Any Shares you receive on vesting will be Shares that are purchased in the market, and will not be Shares
that are treasury shares or are newly issued.

10.2 Unless RemCo decides otherwise, the maximum Market Value of Shares (determined at the Date of Grant) which
may be subject to any Award in respect of any Eligible Employee in any financial year of AZ will be 500% of the Eligible Employee's basic
salary.

11. **Administration** 

The Plan will be administered by RemCo which will interpret and construe any provision of the Plan and may adopt any regulations for administering the Plan and any documents it thinks appropriate. The decision of RemCo on any matter concerning the Plan will be final and binding.

11.1 Any communication in connection with the Plan (including any award documentation) can be given electronically
by e-mail or on an online portal designed for the purpose or by personal delivery or post, (in the case of a company, to its registered
office and in the case of an individual to the individual's last known address) or by any other means which AZ and you use to communicate
with each other.

11.2 Any notice under the Plan will be given: (i) if delivered personally, at the time of delivery; (ii) if
posted, at 10.00 a.m. on the third business day after it was put into the post; or (iii) if sent by e-mail or any other form
of electronic delivery system, at the time of despatch.

12. **General** 

12.1 You may be required to acknowledge the grant of your Award and accept its terms, in which case AZ will
notify you of this requirement. If you fail to acknowledge any Award and accept its terms within any time period notified to you, RemCo
shall have the discretion to lapse your Award without further notice to you or to apply any additional conditions to the vesting of your
Award or Shares received on vesting of your Award as it may determine.

12.2 Your Award may not be sold, transferred, assigned, charged or otherwise encumbered or disposed of to any
person, other than to your personal representatives on your death.

12.3 Participation in the Plan is not pensionable and does not form part of your employment contract. Nothing
in the Plan or any document under it will give any person any right to participate in the Plan and the grant of an Award does not create
any right or expectation to the grant of an Award in the future. Your rights and obligations under the terms of your office or Employment
will not be affected by your participation in the Plan or any right which you may have to participate under it.

12.4 By accepting an Award under the Plan, you waive all and any rights to compensation or damages under the
Plan in consequence of any loss of rights under the Plan as a result of: (i) termination of your office or Employment with a member
of the AZ Group for any reason; or (ii) the way in which RemCo or any person to whom RemCo has delegated authority, exercises or
does not exercise any discretion under the Plan. Nothing in the Plan or in any document executed under it will give you any right to continue
in Employment or will affect the right of any member of the AZ Group to terminate your Employment without liability at any time with or
without cause.

12.5 The invalidity or non-enforceability of one or more provisions of the Plan will not affect the validity
or enforceability of the other provisions of the Plan, which will remain in full force and effect.

12.6 The Plan was adopted by RemCo on 13 December 2023 and amended by RemCo on 3 February 2025 and
11 December 2025. The Plan will terminate on 13 December 2033 or at any earlier time AZ decides. Termination of the Plan will
not affect your Awards.

12.7 Nothing in this Plan confers any benefit, right or expectation on a person who is not an Eligible Employee
or member of the AZ Group, and no third party has any rights under the Contracts (Rights of Third Parties) Act 1999 to enforce any term
of this Plan. This does not affect any other right or remedy of a third party which may exist.

12.8 These Rules will be governed by and construed in accordance with the law of England. You, AZ and
any member of the AZ Group submit to the jurisdiction of the English courts in relation to anything arising under the Plan. RemCo may
determine that another law will apply to the operation of the Plan outside the United Kingdom.

**Appendix 1**

**Definitions and Interpretation**

**Award** means a contingent right to acquire Shares granted or proposed to be granted under **Rule ‎1**;

**AZ** means AstraZeneca PLC (registered number 2723534);

**AZ Group** means AZ and any subsidiary, holding company or subsidiary of a holding company of AZ (as each term is defined in section 1159 Companies Act 2006);

**Closed Period** means a period when you are prohibited from dealing in Shares under the UK Market Abuse Regulation, the Criminal Justice Act 1993, or under any other statute, regulation or similar code to which AZ is subject or other share dealing code adopted by AZ from time to time;

**Control** shall have the meaning given in section 995 Income Tax Act 2007;

**Date of Grant** means with respect to an Award, the date on which the Award is granted;

**Dealing Day** means a day on which the New York Stock Exchange (or, if relevant and if RemCo determines, any stock exchange nominated by RemCo on which the Shares are traded) is open for the transaction of business;

**DI** means a depositary interest issued through CREST representing a beneficial interest in an ordinary share in the capital of AZ;

**Eligible Employee** means any person who at a Date of Grant is an employee of any member of the AZ Group but not an executive director of AZ;

**Employment** means employment as an employee of any member of the AZ Group;

**Malus and Clawback Global Standard** means the malus and clawback global standard approved by RemCo and which came into effect on 1 December 2023, as amended from time to time;

**Market Value** means, in relation to an ordinary share on any day, an amount equal to the average of the middle market closing prices of a Share (as derived from the New York Stock Exchange Listings Directory) on the three consecutive Dealing Days preceding that day (or such other Dealing Day or Dealing Days as RemCo may decide) or, in the case of a DI, by reference to the average of the equivalent price of a DI as derived from the Daily Official List of the London Stock Exchange plc on trading days as close as possible to those Dealing Days. In the event that the ordinary shares cease to be traded on the New York Stock Exchange and are admitted to trading on a replacement market, references to the New York Stock Exchange shall be construed as references to the equivalent of such replacement market. In the event that DIs cease to be traded on the Main Market of the London Stock Exchange and are admitted to trading on a replacement market, references to the London Stock Exchange shall be construed as references to such replacement market;

**Plan** means the AstraZeneca Restricted Share Plan constituted by these Rules;

**RemCo** means the duly authorised remuneration committee of the board of directors of AZ;

**Share** means a fully paid ordinary share in the capital of AZ or, where the context requires it, an equivalent number of DIs;

**Shareholding Arrangement** means the nominee or custodian arrangement referred to in **Rule** ‎**5.1**;

**Tax Liabilities** means any income tax, employee's national insurance contributions, social security charges or similar taxes or charges imposed in any jurisdiction for which AZ or any member of the AZ Group is required to account;

**Variation** means a capitalisation issue, rights issue, subdivision, consolidation, reduction, or any other variation in the capital of AZ;

**Vesting Date** means in relation to an Award the date specified at the Date of Grant, save that if such date falls within a Closed Period, unless RemCo has made a determination under **Rule** ‎**5.5**, the Vesting Date will be the first Dealing Day following the end of that Closed Period;

**Vesting Period** means in relation to an Award, the period between the Date of Grant of the Award and the Vesting Date; and

**You** means any Eligible Employee to whom an Award has been granted, or (where the context requires) that Eligible Employee's personal representatives, and "**your**" shall be construed accordingly.

**Interpretation**

Headings are for convenience only. Words in the singular include the plural and vice versa and words importing gender include both genders. Reference to statutory provisions include amendments, extensions or re-enactments and equivalent legislation in any country other than England, and include any regulations or subordinate legislation made under them.

**Appendix 2**

**Schedule for US Participants**

The provisions of sections ‎1 to ‎5 of this Schedule modify the Rules of the Plan in respect of any Awards granted under it to Eligible Employees who are resident in the United States.

1. The following shall be inserted as new **Rule 2.3**:

"You may be required, as a condition of the vesting of your Award, to represent and agree that, in relation to Shares you acquire under the Plan:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) you understand that such Shares are deemed to be restricted securities within the meaning of Rule 144
under the United States Securities Act of 1933 (the "Securities Act"), which may not be resold in the United States or to a
U.S. person except pursuant to an effective registration statement under the Securities Act or an exemption from the registration requirements
of the Securities Act;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) you are acquiring such Shares for investment and not with a view to distribution; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) you will not resell such Shares at any time, except to non-U.S. persons in transactions effected in accordance
with Rule 904 of Regulation S under the Securities Act (or any successor section thereto) and only after the expiration of any holding
period RemCo may require.

AZ may endorse on certificates representing Shares issued or transferred upon the vesting of an Award such legend referring to the foregoing representations or restrictions or any other applicable restrictions on resale as AZ, in its discretion, shall deem appropriate."

2. In the definition of "AZ Group", "subsidiary" shall be defined as any company in which
AZ owns, directly or indirectly, a majority of the voting rights.

3. In **Rule** ‎ **3.2.3**, the words "redundancy within the terms of the Employment Rights
Act 1996" shall be deleted and replaced by "Redundancy".

4. In **Rule** ‎ **3.2.4**, the words "circumstances determined by RemCo, or anyone authorised
by RemCo, to be retirement" shall be deleted and replaced by "Retirement".

5. In ‎ **Appendix 1 (Definitions)** the following definitions shall be inserted:

"**Redundancy** means a qualifying involuntary termination without cause (but excluding a termination by mutual agreement or mutual consent) entitling you to a severance payment under a severance program adopted by your U.S. employing company. Vesting under these Rules following your redundancy termination is subject always to your having met all the requirements of such severance program, including having executed a valid release of all and any claims against the AZ Group;"

"**Retirement** means:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) termination without cause after having attained age 62 with 5 years of service;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) termination without cause after having attained age 65 with 3 years of service; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) any other meaning as may be notified to you in writing at the time of grant of your Award;".

The remaining provisions of this Schedule modify the Rules of the Plan in respect of any Awards granted under it to Eligible Employees who are US taxpayers (whether or not they are also resident in the United States).

6. **Rule** ‎ **2.2** shall be deleted and replaced with the following:

"Subject to **Rules** ‎**3,** ‎**7** and **‎8**, your Award will vest on the Vesting Date, to the extent that any terms and conditions imposed under **Rule** ‎**2.1** have been met. For the avoidance of doubt, you shall have no rights in respect of the Shares the subject of an Award until the Award has vested. If vesting of an Award would be prohibited by a Closed Period, the day on which the Award vests will be the first Dealing Day on which such prohibition ceases to apply or, if later, the first day on which you are able to trade in the Shares after the Closed Period ceases. In any event, the latest day by which the Shares subject to an Award will be delivered to you is the US Taxpayer Payment Deadline (as defined in **Rule** ‎**5.1** (as inserted by **paragraph** ‎**7** of this ‎**Appendix 2**))."

7. **Rule** ‎ **5.1** shall be deleted and replaced with the following:

"After vesting of your Award, the Shares subject to such an Award in respect to which it has vested will, subject to **Rule** ‎**6**, be delivered to you as soon as practicable following the vesting of the Award, but in no event later than the end of the year in which the applicable vesting date occurs, or, if later, by the 15th day of the third month following the applicable vesting date (collectively, the "**US Taxpayer Payment Deadline**"). You will not be permitted, either directly or indirectly, to designate the year of payment. In the event that an Award vests by reason of Redundancy and your termination of Employment occurs in the calendar year preceding the deadline for you to execute and submit a valid release of claims (if any) required by the applicable severance program, then the year of payment will be the year of the release deadline regardless of whether you earlier submit the release."

"Your Shares may be transferred into any nominee or other custodian arrangement as AZ shall determine is appropriate (**Shareholding Arrangement**) and will be held on your behalf on the terms notified to you from time to time."

8. **Rule** ‎ **5.4** shall be deleted and replaced with the following:

"To the extent that your Award vests, you may, at the discretion of RemCo, receive an amount equivalent to the total dividends paid or which are payable on the number of Shares that vest, by reference to dividend record dates during the Vesting Period, or if your Award vests early, until the date of such vesting. This payment will be made in cash or Shares, subject to deductions for Tax Liabilities, after your Award has vested, but in no event later than the US Taxpayer Payment Deadline (as defined in **Rule** ‎**5.1** (as inserted by **paragraph** ‎**7** of this ‎**Appendix 2**))."

9. The following shall be inserted as a new **Rule 7.5**:

"If an Award vests pursuant to this **Rule** ‎**7**, and the event described in **Rule** ‎**7** also constitutes a "change in control event" under Section 409A of the US Internal Revenue Code of 1986, as it may be amended from time to time, and all regulations, interpretations and administrative guidance issued thereunder (the "Code"), then the Shares subject to it in respect of which it has vested will, subject to **Rule** ‎**6**, be transferred to you as soon as practicable following the vesting of an Award, but in no event later than the US Taxpayer Payment Deadline. If such event does not constitute a "change in control event" under Section 409A of the Code, then the Award will vest on the occurrence of such event described in **Rule** ‎**7**, but shall not be delivered to you until the earlier of the Vesting Date or the date on which your Award vests under **Rule** ‎**3**. For the avoidance of doubt, an Award shall only become payable upon the earlier of the Vesting Date or the date upon which your Award vests under **Rule** ‎**3** or **Rule** ‎**7.**"

10. The following shall be inserted as a new **Rule 13**:

"13. Section 409A of the Code.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.1 The compensation and benefits under the Plan are intended to comply with the requirements of Section 409A
of the Code, and the Plan will be interpreted and administered in a manner consistent with that intent. The preceding provision, however,
shall not be construed as a guarantee by AZ of any particular tax effect to you under an Award. Payment may only be accelerated or delayed
if and to the extent that such accelerated or delayed payment is permitted under Section 409A of the Code.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.2 References to "end of Employment", "cessation of Employment", "termination of
Employment" and similar terms used in the Plan mean, to the extent necessary to comply with Section 409A of the Code, the date
that you first incur a "separation from service" within the meaning of Section 409A of the Code.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.3 Notwithstanding anything in the Plan to the contrary, if at the time of your separation from service with
AZ you are a "specified employee" as defined in Section 409A of the Code, and any payment payable under the Plan as a result
of such separation from service is required to be delayed by six months pursuant to Section 409A of the Code, then AZ will make such
payment on the date that is six months following your separation from service with AZ. The amount of such payment will equal the sum of
the payments that would have been paid to you during the six-month period immediately following your separation from service had the payment
commenced as of such date and will not include interest.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.4 No Shares issued or payments made in respect of such an Award shall be funded with any assets set aside
in a trust or other arrangement in violation of Section 409A(b)(1) of the Code. To the extent any trust is utilized in administration
of the Plan, Awards granted to Eligible Employees who are US taxpayers need not be settled by Shares held in such a trust and such Awards
do not form the basis for any claims or rights with respect to such a trust's assets.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.5 In the first taxable year in which you become a US taxpayer by reason of becoming a resident alien for
US federal income tax purposes, the Plan may be amended solely with respect to you such that the compensation and benefits under the Plan
are compliant with or exempt from Section 409A of the Code. Such amendment must be effective not later than the end of the first
year in which you become a resident alien and shall only be effective with respect to amounts that were not vested prior to the date that
you became a resident alien. For any year after the first year in which you are classified as a resident alien, this clause shall not
apply, provided that a year may again be treated as the first year in which you are classified as a resident alien if you are classified
as a resident alien in that year and have not been classified as a resident alien for the three consecutive years immediately preceding
that year. This clause will be interpreted consistent with the requirements of Section 409A of the Code, including Sections 1.409A-2(c) and
1.409A-3(h) of the US Treasury Regulations, as well as any subsequent guidance under Section 409A of the Code.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.6 Awards under the Plan that become vested while you are not subject to US federal income taxation but that
are paid at a time when you subsequently have become subject to US federal income taxation are intended to be exempt from Section 409A
of the Code. This clause will be interpreted consistent with the requirements of Section 409A of the Code, including Section 1.409A-1(b)(8)(ii) of
the US Treasury Regulations, as well as any subsequent guidance under Section 409A of the Code."

11. **Rule** ‎ **3.3** shall be deleted and replaced with the following:

"For the purposes of this **Rule** ‎**3**, if you are on an authorized leave of absence pursuant to an AZ policy or a legal entitlement, you will not end Employment until the earlier of the date on which you notify your employer of your intention not to return to work or the date on which you cease to have statutory or contractual rights to return to work."

12. The following sentence shall be appended to the end of the existing **Rule** ‎ **8:** 

"Notwithstanding anything to the contrary, this **Rule** ‎**8** shall not apply in any jurisdiction where its enforcement would be prohibited by applicable law."

**Appendix 3**

**France**

1. **This ‎Appendix 3 governs the grant of Awards to French Participants** 

This ‎**Appendix 3** modifies the Rules of the Plan in respect of any Awards granted to participants who are French Participants.

This ‎**Appendix 3** has been drafted in order to allow Awards to benefit from the tax incentive as implemented under articles L.225-197-1 to L.225-197-3, L. 22-10-59 and L.22-10-60 of the French Commercial Code, articles 80 *quaterdecies* of the French Tax Code and articles L.137-13 and L.242-1 of the French Social Security Code. The current provisions of this ‎**Appendix 3** include the regulations currently applicable in France. AZ may however have to amend the provisions of this ‎**Appendix 3** to take into account any new regulations that could arise in the future.

It is anticipated that Awards will be eligible for favourable tax and social security treatment in France. In the case where Awards would not benefit from the favourable tax and social security treatment in France, the French Participants are informed that they may have to bear the cost of any additional income tax arising as a result of the Award and, if requested by their employer, to reimburse their employer for any employee share of social security contributions, but not the employer social security contributions, (and any assimilated charges such as, but not limited to, the *Contribution Sociale Généralisée*).

The provisions of this ‎**Appendix 3** may be subsequently amended, if Awards appear not to be eligible for the favourable tax and social security treatment in France.

2. **Adoption of French Qualified Part** 

The Plan and authority to adopt ‎**Appendix 3** was approved by the shareholders of AZ on 1 March 2010, in compliance with the law under which AZ is incorporated. This ‎**Appendix 3** was adopted by RemCo on 13 December 2023.

In **Rule** ‎**1** of the Plan, the following words shall be inserted:

"No Award shall be granted under ‎**Appendix 3:** (i) more than seventy-six months after the latest date on which this ‎**Appendix 3** was amended by RemCo."

3. **The individual limit** 

The following limits shall apply in respect of Awards granted under the Rules of the Plan to French Participants:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) an Eligible Employee may not own more than 10% of the ordinary share capital of AZ at the date an Award
is granted; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) an Eligible Employee may not own, as a result of the grant of an Award, more than 10% of the ordinary
share capital of AZ.

Only shares in AZ that have been held directly by an Eligible Employee for less than seven years are included in these percentages.

4. **Early vesting of an Award** 

**Rules** ‎**3.1** and ‎**3.2** of the Plan shall be deleted and replaced by the following:

"If a French Participant ceases to be in Employment before the Vesting Date:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) as an Eligible Leaver, and in AZ's opinion the French Participant's Award was granted at the time of his
recruitment into the AZ Group as a sign-on award, or in compensation for any awards or bonuses forfeited at his previous employer, his
Award(s) will vest on the date the Employment ceases, pro-rated to take into account the period elapsed between the Date of Grant
and the date of cessation of Employment relative to the Vesting Period, unless RemCo decides not to pro-rate or to pro-rate on some other
basis; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) other than as set out in (a) above, the Award will lapse on the date of cessation, unless RemCo,
in its absolute discretion, decides otherwise, in which case RemCo has discretion to decide when and to what extent the Award may vest.

If a French Participant dies, the Shares will be transferred to the French Participant's personal representatives, provided that AZ has received written confirmation that the personal representatives are legally authorised to deal with the deceased French Participant's affairs, within 6 months after the death of the relevant French Participant. The terms under which the Shares would be transferred to the personal representatives and the ability for the personal representatives to dispose of the Shares will be determined according to the law and regulation applicable at the date of grant of the Award.

If an Award vests before the Vesting Date for any reason pursuant to the Plan, the French Participant may freely dispose of the Shares subject to it and in respect of which it has vested. However, in such circumstances, unless an Award vests following a French Participant ceasing Employment due to death, injury or disability corresponding to the second and third category as described under article L.341-4 of the French Social Security Code, the French Participant shall bear the cost of any additional income tax arising as a result of the early vesting of the Award and, if requested by their employer, will reimburse their employer for any employee share of social security contributions (and any assimilated charges such as, but not limited to, the *Contribution Sociale Généralisée*)."

5. **Payments on account of dividends** 

**Rule** ‎**5.4** of the Plan shall be deleted. No amounts shall be paid to French Participants or Directors in respect of dividends that would have been paid on the Shares that are subject to the Award during the Vesting Period.

6. **Exchange of Awards** 

**Rule** ‎**7.4** shall apply to French Participants. If there is an exchange of Awards for other awards upon a merger or a demerger realised in accordance with the applicable legislation during the Vesting Period, the preferential tax and social regime would continue to apply provided that the French Participant retains the shares received until the end of the Vesting Period.

In any other cases of an exchange of Awards, the French Participant shall bear the cost of any additional income tax arising as a result of the exchange of Awards and, if requested by their employer, will reimburse their employer for any employee share of social security contributions (and any assimilated charges such as, but not limited to, the *Contribution Sociale Généralisée).*

7. **Limit on the number of shares which can be issued** 

If the Plan is amended at any time to permit Awards to be satisfied using newly issued Shares, no Award may be granted to French Participants or Directors if the number of Shares issued or capable of being issued pursuant to Awards granted under the Plan, when aggregated with the number of shares issued or capable of being issued pursuant to awards made or options granted under any other employees' share scheme, would exceed 10 per cent of the ordinary issued share capital of AZ from time to time.

This 10 per cent limit does not include:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) any Shares that have not been effectively awarded at the end of the Vesting Period; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) any Shares that are no longer subject to a Vesting Period.

8. **Sale restriction** 

After the Vesting Date, a French Participant or Director who is an employee of a Participating Company cannot transfer the Shares:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) Within the thirty (30) calendar days before the announcement of an interim financial report or a year-end
report that AZ is required to make public.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) At any time when the French Participant or Director is in possession of Privileged Information.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) And in any case before the end of the Holding Period (if any).

9. **Definitions** 

For the purpose of this ‎**Appendix 3,** the following definitions will apply instead of the definitions in ‎**Appendix 1:**

**Director** means any Président du Conseil d'Administration, Président (as far as a *société par actions simplifiée* is concerned), Directeur Général, Directeur Général Délégué or Membre du Directoire of a Participating Company.

**Eligible Employee** means any person who at a Date of Grant is in Employment with a Participating Company.

**Eligible Leaver** means a French Participant who ceases to be in Employment as a result of death, injury or disability corresponding to the second and third category as described under article L.341-4 of the French Social Security Code, ill-health, redundancy (provided that, in the case of ill-health or redundancy, the Participant's employing company does not dispute that these are the reasons for the cessation), retirement with the agreement of his employing company, his employing company ceasing to be a member of the AZ Group or the business in which he is employed being transferred out of the AZ Group.

**Employment** means employment as an employee or Director of a Participating Company, though a Participating Company may decide on a case by case basis to include or exclude Directors from this ‎**Appendix 3.**

**French Participant** means a participant in the Plan who is in Employment at a Participating Company and/or an Eligible Employee as defined in the main Rules of the Plan who is a French tax resident and is subject to French social security regulation.

**Holding Period** means in relation to an Award that vests less than two years after the Date of Grant, the period specified on the Date of Grant starting on the Vesting Date and ending at the earliest on the second anniversary of the Date of Grant. Notwithstanding the foregoing, unless RemCo has made a determination under **Rule ‎5.5**, if the last day of the Holding Period falls within a Closed Period, the last day of the Holding Period will be the first Dealing Day following the end of that Closed Period.

**Participating Company** means any French subsidiary of AZ within the meaning of section I of Article L225-197-2° of the French Commercial Code; provided, for the avoidance of doubt, that a company shall be a French subsidiary only if AZ holds, directly or indirectly, at least 10 per cent. of its share capital or voting rights.

**Privileged Information** means privileged information within the meaning of Article 7 of Regulation (EU) No. 596/2014 of the European Parliament and of the Council of 16 April 2014 on market abuse (Market Abuse Regulation) which has not been made public.

**Vesting Date** means in relation to an Award the date specified at the Date of Grant and determined by RemCo so that the Vesting Period shall be at least one year, save that if such date falls within a Closed Period, unless RemCo has made a determination under **Rule 5.5**, the Vesting Date will be the first Dealing Day following the end of that Closed Period.

## Exhibit 4.3

**Exhibit 4.3**

Plan Rules of the AstraZeneca Global Restricted Stock Plan

Adopted by RemCo on 1 March 2010 and restated on 22 October 2019 and amended on 25 September 2020, 27 April 2022,<br> 13 December 2023, 3 February 2025, and 11 December 2025.<br> Plan terminates on 22 October 2029

French Appendix restated by RemCo on 11 December 2025.

**AstraZeneca Global Restricted Stock Plan**

*<u>What is an 'award' and when do you get shares?</u>*

An award under the Plan is a contingent right to receive shares in AstraZeneca PLC. When your award 'vests' you receive shares.

Your award will normally vest a specified number of years after grant. After your award vests, you will receive a net number of shares after withholdings for tax have been made. Your shares will be transferred into a nominee or custodian arrangement for you.

*<u>What happens if you leave?</u>*

Awards will generally only vest if you are employed. If you leave AZ within the specified number of years after grant, your unvested awards will normally lapse.

However, if you end employment for one of the following reasons:

&nbsp;&nbsp;&nbsp;&nbsp;(a) death,

&nbsp;&nbsp;&nbsp;&nbsp;(b) ill-health, injury or disability (in each case evidenced to the satisfaction of your employer),

&nbsp;&nbsp;&nbsp;&nbsp;(c) redundancy (within the terms of the Employment Rights Act 1996),

&nbsp;&nbsp;&nbsp;&nbsp;(d) circumstances determined by RemCo to be retirement, or

&nbsp;&nbsp;&nbsp;&nbsp;(e) the company or business in which you are employed ceasing to be a member of the AZ group,

your award will not lapse and it will normally vest on the date you cease employment, pro-rated for the time you were in employment.

*<u>Change of control of AstraZeneca</u>*

If there is a change in control of AZ, your award will vest pro-rata (subject to achievement of any performance targets).

*<u>Dividends</u>*

On vesting, you will receive cash or additional shares to reflect any dividends that would have been paid to you had you held the shares that vest on any dividend record dates during the Vesting Period (dividend equivalents).

*<u>General</u>*

Awards are personal to you and may not be transferred or charged until they vest. The awards do not form part of your terms and conditions of employment and are not pensionable.

You may be required to acknowledge the grant of your award and agree to certain terms.

This summary does not form part of the Rules of the GRSP. The Rules of the GRSP are set out in the following pages and will govern how your awards are treated. Definitions and interpretation provisions are at Appendix 1. If you are resident in a country outside of the UK, your award may be subject to special terms.

**Rules of the AstraZeneca Global Restricted Stock Plan**

**1.** **Grant of Awards** 

RemCo may approve the grant of Awards to Eligible Employees, subject to the limits in **Rule 10**. Awards will not be granted during a Closed Period.

**2.** **Vesting of Awards** 

2.1 Vesting of your Award is subject to such terms and conditions as RemCo considers appropriate before grant.

2.2 Unless your Award vests early under **Rules 3** or **7**, your Award will vest on the Vesting
Date to the extent that any terms and conditions imposed under **Rule 2.1** have been met.

**3.** **End of Employment** 

3.1 If you end Employment before the Vesting Date other than in any of the circumstances set out in **Rule 3.2**,
your Award will lapse unless RemCo in its absolute discretion decides otherwise, in which case RemCo has discretion to decide when and
to what extent your Award may vest.

3.2 If you end Employment before the Vesting Date for one of the following reasons:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.1 death;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.2 ill-health, injury or disability (in each case evidenced to the satisfaction of your employing company);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.3 redundancy within the terms of the Employment Rights Act 1996;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.4 circumstances determined by RemCo, or anyone authorised by RemCo, to be retirement; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.5 the company by which you are employed ceasing to be a member of the AZ Group, or the part of the business
in which you are employed being transferred to a person outside the AZ Group,

your Award will vest on the date you end Employment, and will be reduced pro-rata to the proportion of the Vesting Period that has elapsed up to the end of Employment, unless RemCo decides not to pro-rate or to pro-rate on some other basis.

3.3 For the purposes of this **Rule 3**, if you are on statutory family-related leave, you will not
end Employment until the earlier of the date on which you notify your employer of your intention not to return to work or the date on
which you cease to have statutory or contractual rights to return to work.

3.4 If you are resident in China and you end Employment as a result of your death, if a delay in providing
the necessary documentation will result in a breach of the Chinese State Administration of Foreign Exchange requirements, your Award shall
not be satisfied by the issue or transfer of Shares but will be satisfied by the payment of a cash sum equal to the value of the Shares
in respect of which your Award vested under **Rule ‎ 3.2** (converted into your relevant
payroll currency at an appropriate spot rate) less deductions for Tax Liabilities.

**4.** **Lapse of Awards** 

4.1 Notwithstanding any other provision of these Rules, your Award will lapse:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.1.1 if you are declared bankrupt or are unable to hold your Award by operation of law, or you attempt to transfer,
assign, charge or dispose of your Award contrary to **Rule 12.2**;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.1.2 to the extent that: (i) the Award does not vest in full under **Rules 3** or **7**; or (ii) the number of Shares which are subject to the Award is reduced under **Rule 8**.

**5.** **Consequences of Vesting of an Award** 

5.1 After vesting of your Award, the number of Shares in respect of which it has vested will, subject to **Rule 6**,
be transferred to you as soon as practicable. Your Shares may be transferred into any nominee or other custodian arrangement as AZ shall
determine is appropriate (**Shareholding Arrangement**) and will be held on your behalf on the terms notified to you from time to time.

5.2 In the event that you end Employment, unless your Shares are required by AZ to be retained in the Shareholding
Arrangement, you will be required to remove your Shares from such Shareholding Arrangement within six months of the date you end Employment.
If your Shares remain in the Shareholding Arrangement at the end of that six month period, AZ will have the right, at any time, to sell
or direct the sale of your Shares on your behalf at the prevailing market rate and will remit the cash proceeds to you or to an account
with a nominee or custodian on your behalf. For the avoidance of doubt, Shares in this **Rule 5.2** shall refer to Shares acquired
on vesting of your Award, including pursuant to **Rule 5.4**, and any additional Shares that are acquired by you as a result of
your holding of such Shares, for example by way of reinvestment of dividends paid on such Shares.

5.3 You will have no voting, dividend or other rights in the Shares under your Award before the Vesting Date.
Shares that you acquire under the Plan will not have the benefit of any rights that attach to those Shares by reference to a record date
that is earlier than the date when you acquired them.

5.4 To the extent that your Award vests you may receive an additional amount as "dividend equivalents". Unless RemCo decides otherwise, your dividend equivalents will be calculated by reference
to the dividends paid or which are payable on the number of Shares that vest, as if those dividends had been reinvested in Shares on the
relevant dividend record dates during the Vesting Period, or if your Award vests early, until the date of such vesting. This payment will
be made in cash or Shares, subject to deductions for Tax Liabilities, after your Award has vested, but no later than 15 March after
the calendar year in which your Award has vested.

5.5 Notwithstanding any other provision, RemCo may, at any time, determine that your Award shall not be satisfied
by the issue or transfer of Shares but will be satisfied by the payment to you of a cash sum equal to the value of the Shares in respect
of which your Award vests on the day of vesting (converted into your relevant payroll currency at an appropriate spot rate) less deductions
for Tax Liabilities.

**6.** **Tax** 

By accepting the Award, you indemnify AZ and your employer against any Tax Liabilities that may arise in connection with the benefits delivered under the Plan. AZ or your employer may withhold any amount and make any arrangements it considers necessary to meet any Tax Liabilities, which may include the sale on your behalf of any Shares acquired by you under the Plan.

**7.** **Change of Control of AZ** 

7.1 If before the Vesting Date of an Award:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.1.1 an offeror (alone or with any party acting in concert with the offeror) obtains Control of AZ by making
an offer to acquire the whole of the issued ordinary share capital of AZ (or any part of it which is not owned by the offeror and any
party acting in concert with the offeror);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.1.2 the Court sanctions a compromise or arrangement affecting the Shares under section 899 of the Companies
Act 2006; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.1.3 a resolution is passed for the voluntary winding up of AZ,

unless **Rule 7.4** applies, your Award will vest on the date of that event, to the extent decided by RemCo under **Rule 7.2**.

7.2 Where **Rule 7.1** applies or is likely to apply, an Award will vest pro-rata to the time which
has elapsed between the Date of Grant of the Award and the date of the relevant event (subject to achievement of any applicable performance
targets, in the opinion of RemCo, at the time of the relevant event or most practicable earlier date). However, RemCo may decide to take
into account any other factors it believes to be relevant in determining the extent to which an Award will vest in circumstances it considers
exceptional.

7.3 RemCo will confirm the extent (if any) to which an Award will vest under **Rule 7.2**. Confirmation
may be before, but conditional on, the relevant event in **Rule 7.1**.

7.4 If a company obtains Control of AZ, but the shareholders of the acquiring company immediately after it
has obtained Control of AZ are substantially the same as the shareholders of AZ immediately before that event, and if the acquiring company
consents to this **Rule 7.4** applying, then your Award will not vest under **Rule 7.1**. Instead, it will be exchanged
for a new award in respect of shares having a total Market Value being equal to the Market Value of the Shares that are subject to your
Award immediately before the exchange. The new award will be governed by the Rules, except that references to Shares shall refer to shares
in the acquiring company, and references to AZ shall refer to the acquiring company.

**8.** **Malus and Clawback** 

Notwithstanding any other provision, Awards are subject to the Malus and Clawback Global Standard and by accepting an Award, you agree to be bound by the terms of the Malus and Clawback Global Standard.

**9.** **Amending the Plan and Awards** 

9.1 If there is a Variation in the equity share capital of AZ, the number and/or the nominal value of the
Shares over which your Award is granted will be adjusted as RemCo decides. You will be notified of any adjustment under **Rule 9.1**.

9.2 AZ can amend these Rules at any time.

9.3 AZ can adopt additional sections of these Rules applicable in any jurisdiction under which Awards
may be subject to additional and/or modified terms and conditions, taking into account any securities, exchange control or taxation laws,
which may apply to you, AZ, or any member of the AZ Group. Any additional sections must conform to the basic principles of the Plan and
must not exceed the limits set out in these Rules.

**10.** **Limit on the number of Shares which can be issued** 

10.1 Any Shares you receive on vesting will be Shares that are purchased in the market, and will not be Shares
that are treasury shares or are newly issued.

10.2 Unless RemCo decides otherwise, the maximum Market Value of Shares (determined at the Date of Grant) which
may be subject to any Award in respect of any Eligible Employee in any financial year of AZ will be 500% of the Eligible Employee's basic
salary.

**11.** **Administration** 

11.1 The Plan will be administered by RemCo which will interpret and construe any provision of the Plan and
may adopt any regulations for administering the Plan and any documents it thinks appropriate. The decision of RemCo on any matter concerning
the Plan will be final and binding.

11.2 Any communication in connection with the Plan (including any award documentation) can be given electronically
by e-mail or on an online portal designed for the purpose or by personal delivery or post, (in the case of a company, to its registered
office and in the case of an individual to the individual's last known address) or by any other means which AZ and you use to communicate
with each other.

11.3 Any notice under the Plan will be given: (i) if delivered personally,
at the time of delivery; (ii) if posted, at 10.00 a.m. on the third business day after it was put into the post; or (iii) if
sent by e-mail or any other form of electronic delivery system, at the time of dispatch.

**12.** **General** 

12.1 You may be required to acknowledge the grant of your Award and accept its terms, in which case AZ will
notify you of this requirement. If you fail to acknowledge any Award and accept its terms within any time period notified to you, RemCo
shall have the discretion to lapse your Award without further notice to you or to apply any additional conditions to the vesting of your
Award or Shares received on vesting of your Award as it may determine.

12.2 Your Award may not be sold, transferred, assigned, charged or otherwise encumbered or disposed of to any
person, other than to your personal representatives on your death.

12.3 Participation in the Plan is not pensionable and does not form part of your employment contract. Nothing
in the Plan or any document under it will give any person any right to participate in the Plan and the grant of an Award does not create
any right or expectation to the grant of an Award in the future. Your rights and obligations under the terms of your office or Employment
will not be affected by your participation in the Plan or any right which you may have to participate under it.

12.4 By accepting an Award under the Plan, you waive all and any rights to compensation or damages under the
Plan in consequence of any loss of rights under the Plan as a result of: (i) termination of your office or Employment with a member
of the AZ Group for any reason; or (ii) the way in which RemCo or any person to whom RemCo has delegated authority, exercises or
does not exercise any discretion under the Plan. Nothing in the Plan or in any document executed under it will give you any right to continue
in Employment or will affect the right of any member of the AZ Group to terminate your Employment without liability at any time with or
without cause.

12.5 The invalidity or non-enforceability of one or more provisions of the Plan will not affect the validity
or enforceability of the other provisions of the Plan, which will remain in full force and effect.

12.6 The Plan was adopted by RemCo on 1 March 2010 and restated on 22 October 2019 and amended on
25 September 2020, 27 April 2022, 13 December 2023, 3 February 2025, and 11 December 2025. The Plan will terminate
on 22 October 2029 or at any earlier time AZ decides. Termination of the Plan will not affect your Awards.

12.7 Nothing in this Plan confers any benefit, right or expectation on a person who is not an Eligible Employee
or member of the AZ Group, and no third party has any rights under the Contracts (Rights of Third Parties) Act 1999 to enforce any term
of this Plan. This does not affect any other right or remedy of a third party which may exist.

12.8 These Rules will be governed by and construed in accordance with the law of England. You, AZ and
any member of the AZ Group submit to the jurisdiction of the English courts in relation to anything arising under the Plan. RemCo may
determine that another law will apply to the operation of the Plan outside the United Kingdom.

**Appendix 1**

**Definitions and Interpretation**

**Award** means a contingent right to acquire Shares granted or proposed to be granted under Rule 1;

**AZ** means AstraZeneca PLC (registered number 2723534);

**AZ Group** means AZ and any subsidiary, holding company or subsidiary of a holding company of AZ (as each term is defined in section 1159 Companies Act 2006);

**Closed Period** means a period when you are prohibited from dealing in Shares under the UK Market Abuse Regulation, the Criminal Justice Act 1993, or under any other statute, regulation or similar code to which AZ is subject or other share dealing code adopted by AZ from time to time;

**Control** shall have the meaning given in section 995 Income Tax Act 2007;

**Date of Grant** means with respect to an Award, the date on which the Award is granted;

**Dealing Day** means a day on which the New York Stock Exchange (or, if relevant and if RemCo determines, any stock exchange nominated by RemCo on which the Shares are traded) is open for the transaction of business;

**DI** means a depositary interest issued through CREST representing a beneficial interest in an ordinary share in the capital of AZ;

**Eligible Employee** means any person who at a Date of Grant is an employee of any member of the AZ Group but not an executive director of AZ;

**Employment** means employment as an employee of any member of the AZ Group;

**Malus and Clawback Global Standard** means the malus and clawback global standard approved by RemCo and which came into effect on 1 December 2023, as amended from time to time;

**Market Value** means, in relation to an ordinary share on any day, an amount equal to the average of the middle market closing prices of a Share (as derived from the New York Stock Exchange Listings Directory) on the three consecutive Dealing Days preceding that day (or such other Dealing Day or Dealing Days as RemCo may decide) or, in the case of a DI, by reference to the average of the equivalent price of a DI as derived from the Daily Official List of the London Stock Exchange plc on trading days as close as possible to those Dealing Days. In the event that the ordinary shares cease to be traded on the New York Stock Exchange and are admitted to trading on a replacement market, references to the New York Stock Exchange shall be construed as references to the equivalent of such replacement market. In the event that DIs cease to be traded on the Main Market of the London Stock Exchange and are admitted to trading on a replacement market, references to the London Stock Exchange shall be construed as references to such replacement market;

**Plan** means the AstraZeneca Global Restricted Stock Plan constituted by these Rules;

**RemCo** means the duly authorised remuneration committee of the board of directors of AZ;

**Share** means a fully paid ordinary share in the capital of AZ or, where the context requires it, an equivalent number of DIs;

**Shareholding Arrangement** means the nominee or custodian arrangement referred to in **Rule 5.1**;

**Tax Liabilities** means any income tax, employee's national insurance contributions, social security charges or similar taxes or charges imposed in any jurisdiction for which AZ or any member of the AZ Group is required to account;

**Variation** means a capitalisation issue, rights issue, subdivision, consolidation, reduction, or any other variation in the capital of AZ;

**Vesting Date** means in relation to an Award the date specified at the Date of Grant, save that if such date falls within a Closed Period, unless RemCo has made a determination under **Rule 5.5**, the Vesting Date will be the first Dealing Day following the end of that Closed Period;

**Vesting Period** means in relation to an Award, the period between the Date of Grant of the Award and the Vesting Date; and

**You** means any Eligible Employee to whom an Award has been granted, or (where the context requires) that Eligible Employee's personal representatives, and "**your**" shall be construed accordingly.

**Interpretation**

Headings are for convenience only. Words in the singular include the plural and vice versa and words importing gender include both genders. Reference to statutory provisions include amendments, extensions or re-enactments and equivalent legislation in any country other than England, and include any regulations or subordinate legislation made under them.

**Appendix 2**

**Schedule for US Participants**

The provisions of sections 1 to 5 of this Schedule modify the Rules of the Plan in respect of any Awards granted under it to Eligible Employees who are resident in the United States.

1. The following shall be inserted as new **Rule 2.3**:

"You may be required, as a condition of the vesting of your Award, to represent and agree that, in relation to Shares you acquire under the Plan:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) you understand that such Shares are deemed to be restricted securities within the meaning of Rule 144
under the United States Securities Act of 1933 (the "Securities Act"), which may not be resold in the United States or to
a U.S. person except pursuant to an effective registration statement under the Securities Act or an exemption from the registration requirements
of the Securities Act;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) you are acquiring such Shares for investment and not with a view to distribution; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) you will not resell such Shares at any time, except to non-U.S. persons in transactions effected in accordance
with Rule 904 of Regulation S under the Securities Act (or any successor section thereto) and only after the expiration of any holding
period RemCo may require.

AZ may endorse on certificates representing Shares issued or transferred upon the vesting of an Award such legend referring to the foregoing representations or restrictions or any other applicable restrictions on resale as AZ, in its discretion, shall deem appropriate."

2. In the definition of "AZ Group", "subsidiary" shall be defined as any company
in which AZ owns, directly or indirectly, a majority of the voting rights.

3. In **Rule 3.2.3**, the words "redundancy within the terms of the Employment Rights Act 1996"
shall be deleted and replaced by "Redundancy".

4. In **Rule 3.2.4**, the words "circumstances determined by RemCo, or anyone authorised by
RemCo, to be retirement" shall be deleted and replaced by "Retirement".

5. In **Appendix 1 (Definitions)** the following definitions shall be inserted:

"**Redundancy** means a qualifying involuntary termination without cause (but excluding a termination by mutual agreement or mutual consent) entitling you to a severance payment under a severance program adopted by your U.S. employing company. Vesting under these Rules following your redundancy termination is subject always to your having met all the requirements of such severance program, including having executed a valid release of all and any claims against the AZ Group;"

"**Retirement** means:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) termination without cause after having attained age 62 with 5 years of service;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) termination without cause after having attained age 65 with 3 years of service; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) any other meaning as may be notified to you in writing at the time of grant of your Award;".

The remaining provisions of this Schedule modify the Rules of the Plan in respect of any Awards granted under it to Eligible Employees who are US taxpayers (whether or not they are also resident in the United States).

6. **Rule 2.2** shall be deleted and replaced with the following:

"Subject to **Rules 3, 7** and **8**, your Award will vest on the Vesting Date, to the extent that any terms and conditions imposed under **Rule 2.1** have been met. For the avoidance of doubt, you shall have no rights in respect of the Shares the subject of an Award until the Award has vested. If vesting of an Award would be prohibited by a Closed Period, the day on which the Award vests will be the first Dealing Day on which such prohibition ceases to apply or, if later, the first day on which you are able to trade in the Shares after the Closed Period ceases. In any event, the latest day by which the Shares subject to an Award will be delivered to you is the US Taxpayer Payment Deadline (as defined in **Rule 5.1** (as inserted by **paragraph 7** of this **Appendix 2**))."

7. **Rule 5.1** shall be deleted and replaced with the following:

"After vesting of your Award, the Shares subject to such an Award in respect to which it has vested will, subject to **Rule 6**, be delivered to you as soon as practicable following the vesting of the Award, but in no event later than the end of the year in which the applicable vesting date occurs, or, if later, by the 15th day of the third month following the applicable vesting date (collectively, the "**US Taxpayer Payment Deadline**"). You will not be permitted, either directly or indirectly, to designate the year of payment. In the event that an Award vests by reason of Redundancy and your termination of Employment occurs in the calendar year preceding the deadline for you to execute and submit a valid release of claims (if any) required by the applicable severance program, then the year of payment will be the year of the release deadline regardless of whether you earlier submit the release."

"Your Shares may be transferred into any nominee or other custodian arrangement as AZ shall determine is appropriate (**Shareholding Arrangement**) and will be held on your behalf on the terms notified to you from time to time."

8. **Rule 5.4** shall be deleted and replaced with the following:

"To the extent that your Award vests, you may, at the discretion of RemCo, receive an amount equivalent to the total dividends paid or which are payable on the number of Shares that vest, by reference to dividend record dates during the Vesting Period, or if your Award vests early, until the date of such vesting. This payment will be made in cash or Shares, subject to deductions for Tax Liabilities, after your Award has vested, but in no event later than the US Taxpayer Payment Deadline (as defined in **Rule 5.1** (as inserted by **paragraph 7** of this **Appendix 2**))."

9. The following shall be inserted as a new **Rule 7.5**:

"If an Award vests pursuant to this **Rule 7**, and the event described in **Rule 7** also constitutes a "change in control event" under Section 409A of the US Internal Revenue Code of 1986, as it may be amended from time to time, and all regulations, interpretations and administrative guidance issued thereunder (the "Code"), then the Shares subject to it in respect of which it has vested will, subject to **Rule 6**, be transferred to you as soon as practicable following the vesting of an Award, but in no event later than the US Taxpayer Payment Deadline. If such event does not constitute a "change in control event" under Section 409A of the Code, then the Award will vest on the occurrence of such event described in **Rule 7**, but shall not be delivered to you until the earlier of the Vesting Date or the date on which your Award vests under **Rule 3**. For the avoidance of doubt, an Award shall only become payable upon the earlier of the Vesting Date or the date upon which your Award vests under **Rule 3** or **Rule 7**."

10. The following shall be inserted as a new **Rule 13**: "13. Section 409A of the Code.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.1 The compensation and benefits under the Plan are intended to comply with the requirements of Section 409A
of the Code, and the Plan will be interpreted and administered in a manner consistent with that intent. The preceding provision, however,
shall not be construed as a guarantee by AZ of any particular tax effect to you under an Award. Payment may only be accelerated or delayed
if and to the extent that such accelerated or delayed payment is permitted under Section 409A of the Code.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.2 References to "end of Employment", "cessation of Employment", "termination
of Employment" and similar terms used in the Plan mean, to the extent necessary to comply with Section 409A of the Code, the
date that you first incur a "separation from service" within the meaning of Section 409A of the Code.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.3 Notwithstanding anything in the Plan to the contrary, if at the time of your separation from service with
AZ you are a "specified employee" as defined in Section 409A of the Code, and any payment payable under the Plan as a
result of such separation from service is required to be delayed by six months pursuant to Section 409A of the Code, then AZ will
make such payment on the date that is six months following your separation from service with AZ. The amount of such payment will equal
the sum of the payments that would have been paid to you during the six-month period immediately following your separation from service
had the payment commenced as of such date and will not include interest.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.4 No Shares issued or payments made in respect of such an Award shall be funded with any assets set aside
in a trust or other arrangement in violation of Section 409A(b)(1) of the Code. To the extent any trust is utilized in administration
of the Plan, Awards granted to Eligible Employees who are US taxpayers need not be settled by Shares held in such a trust and such Awards
do not form the basis for any claims or rights with respect to such a trust's assets.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.5 In the first taxable year in which you become a US taxpayer by reason of becoming a resident alien for
US federal income tax purposes, the Plan may be amended solely with respect to you such that the compensation and benefits under the Plan
are compliant with or exempt from Section 409A of the Code. Such amendment must be effective not later than the end of the first
year in which you become a resident alien and shall only be effective with respect to amounts that were not vested prior to the date that
you became a resident alien. For any year after the first year in which you are classified as a resident alien, this clause shall not
apply, provided that a year may again be treated as the first year in which you are classified as a resident alien if you are classified
as a resident alien in that year and have not been classified as a resident alien for the three consecutive years immediately preceding
that year. This clause will be interpreted consistent with the requirements of Section 409A of the Code, including Sections 1.409A-2(c) and
1.409A-3(h) of the US Treasury Regulations, as well as any subsequent guidance under Section 409A of the Code.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.6 Awards under the Plan that become vested while you are not subject to US federal income taxation but that
are paid at a time when you subsequently have become subject to US federal income taxation are intended to be exempt from Section 409A
of the Code. This clause will be interpreted consistent with the requirements of Section 409A of the Code, including Section 1.409A-1(b)(8)(ii) of
the US Treasury Regulations, as well as any subsequent guidance under Section 409A of the Code."

11. **Rule 3.3** shall be deleted and replaced with the following:

"For the purposes of this **Rule 3**, if you are on an authorized leave of absence pursuant to an AZ policy or a legal entitlement, you will not end Employment until the earlier of the date on which you notify your employer of your intention not to return to work or the date on which you cease to have statutory or contractual rights to return to work."

12. The following sentence shall be appended to the end of the existing **Rule 8**:

"Notwithstanding anything to the contrary, this **Rule 8** shall not apply in any jurisdiction where its enforcement would be prohibited by applicable law."

**Appendix 3**

**France**

1. **This Appendix 3 governs the grant of Awards to French Participants** 

This **Appendix 3** modifies the Rules of the Plan in respect of any Awards granted to participants who are French Participants.

This **Appendix 3** has been drafted in order to allow Awards to benefit from the tax incentive as implemented under articles L.225-197-1 to L.225-197-3, L.22-10-59 and L.22-10-60 of the French Commercial Code, articles 80 *quaterdecies* of the French Tax Code and articles L.137-13 and L.242-1 of the French Social Security Code. The current provisions of this **Appendix 3** include the regulations currently applicable in France. AZ may however have to amend the provisions of this **Appendix 3** to take into account any new regulations that could arise in the future.

It is anticipated that Awards will be eligible for favourable tax and social security treatment in France. In the case where Awards would not benefit from the favourable tax and social security treatment in France, the French Participants are informed that they may have to bear the cost of any additional income tax arising as a result of the Award and, if requested by their employer, to reimburse their employer for any employee share of social security contributions, but not the employer social security contributions, (and any assimilated charges such as, but not limited to, the *Contribution Sociale Généralisée*).

The provisions of this **Appendix 3** may be subsequently amended, if Awards appear not to be eligible for the favourable tax and social security treatment in France.

This **Appendix 3** applies to Awards granted as from 1 January 2010 and, as amended, to Awards granted as from 3 February 2014 and, as further amended, to Awards granted as from 24 July 2017 and, as restated, to Awards granted as from 11 December 2025.

2. **Adoption of French Qualified Part** 

The Plan and authority to adopt **Appendix 3** was approved by the Board on 1 March 2010 and restated by RemCo on 22 October 2019, in compliance with the law under which AZ is incorporated. This **Appendix 3** was adopted by RemCo on 1 March 2010, and restated on 22 October 2019, and further restated on 11 December 2025.

In **Rule 1** of the Plan, the following words shall be inserted:

"No Award shall be granted under **Appendix 3**: (i) more than seventy-six months after the date on which this **Appendix 3** was restated by RemCo."

3. **The individual limit** 

The following limits shall apply in respect of Awards granted under the Rules of the Plan to French Participants:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) an Eligible Employee may not own more than 10% of the ordinary share capital of AZ at the date an Award
is granted; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) an Eligible Employee may not own, as a result of the grant of an Award, more than 10% of the ordinary
share capital of AZ.

Only shares in AZ that have been held directly by an Eligible Employee for less than seven years are included in these percentages.

4. **Early vesting of an Award** 

**Rules 3.1** and **3.2** of the Plan shall be deleted and replaced by the following:

"If a French Participant ceases to be in Employment before the Vesting Date:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) as an Eligible Leaver, his Award(s) will vest on the date the Employment ceases, pro-rated to take
into account the period elapsed between the Date of Grant and the date of cessation of Employment relative to the Vesting Period, unless
RemCo decides not to pro-rate or to pro-rate on some other basis; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) other than as an Eligible Leaver, the Award will lapse on the date of cessation, unless RemCo, in its
absolute discretion, decides otherwise, in which case RemCo has discretion to decide when and to what extent the Award may vest.

If a French Participant dies, the Shares will be transferred to the French Participant's personal representatives, provided that AZ has received written confirmation that the personal representatives are legally authorised to deal with the deceased French Participant's affairs, within 6 months after the death of the relevant French Participant. The terms under which the Shares would be transferred to the personal representatives and the ability for the personal representatives to dispose of the Shares will be determined according to the law and regulation applicable at the date of grant of the Award.

If an Award vests before the Vesting Date for any reason pursuant to the Plan, the French Participant may freely dispose of the Shares subject to it and in respect of which it has vested. However, in such circumstances, unless an Award vests following a French Participant ceasing Employment due to death, injury or disability corresponding to the second and third category as described under article L.341-4 of the French Social Security Code, the French Participant shall bear the cost of any additional income tax arising as a result of the early vesting of the Award and, if requested by their employer, will reimburse their employer for any employee share of social security contributions (and any assimilated charges such as, but not limited to, the *Contribution Sociale Généralisée*)."

5. **Payments on account of dividends** 

**Rule 5.4** of the Plan shall be deleted. No amounts shall be paid to French Participants or Directors in respect of dividends that would have been paid on the Shares that are subject to the Award during the Vesting Period.

6. **Exchange of Awards** 

**Rule 7.4** shall apply to French Participants. If there is an exchange of Awards for other awards upon a merger or a demerger realised in accordance with the applicable legislation during the Vesting Period, the preferential tax and social regime would continue to apply provided that the French Participant retains the shares received until the end of the Vesting Period.

In any other cases of an exchange of Awards, the French Participant shall bear the cost of any additional income tax arising as a result of the exchange of Awards and, if requested by their employer, will reimburse their employer for any employee share of social security contributions (and any assimilated charges such as, but not limited to, the *Contribution Sociale Généralisée*).

7. **Limit on the number of shares which can be issued** 

If the Plan is amended at any time to permit Awards to be satisfied using newly issued Shares, no Award may be granted to French Participants or Directors if the number of Shares issued or capable of being issued pursuant to Awards granted under the Plan, when aggregated with the number of shares issued or capable of being issued pursuant to awards made or options granted under any other employees' share scheme, would exceed 10 per cent of the ordinary issued share capital of AZ from time to time.

This 10 per cent limit does not include:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) any Shares that have not been effectively awarded at the end of the Vesting Period; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) any Shares that are no longer subject to a Vesting Period.

8. **Sale restriction** 

After the Vesting Date, a French Participant or Director who is an employee of a Participating Company cannot transfer the Shares:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) Within the thirty (30) calendar days before the announcement of an interim financial report or a year-end
report that AZ is required to make public.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) At any time when the French Participant or Director is in possession of Privileged Information.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) And in any case before the end of the Holding Period (if any).

9. **Definitions** 

For the purpose of this **Appendix 3**, the following definitions will apply instead of the definitions in **Appendix 1**:

**Director** means any Président du Conseil d'Administration, Président (as far as a *société par actions simplifiée* is concerned), Directeur Général, Directeur Général Délégué or Membre du Directoire of a Participating Company.

**Eligible Employee** means any person who at a Date of Grant is in Employment with a Participating Company.

**Eligible Leaver** means a French Participant who ceases to be in Employment as a result of death, injury or disability corresponding to the second and third category as described under article L.341-4 of the French Social Security Code, ill-health, redundancy (provided that, in the case of ill-health or redundancy, the Participant's employing company does not dispute that these are the reasons for the cessation), retirement with the agreement of his employing company, his employing company ceasing to be a member of the AZ Group or the business in which he is employed being transferred out of the AZ Group.

**Employment** means employment as an employee or Director of a Participating Company, though a Participating Company may decide on a case by case basis to include or exclude Directors from this **Appendix 3**.

**French Participant** means a participant in the Plan who is in Employment at a Participating Company and/or an Eligible Employee as defined in the main Rules of the Plan who is a French tax resident and is subject to French social security regulation.

**Holding Period** means in relation to an Award that vests less than two years after the Date of Grant, the period specified on the Date of Grant starting on the Vesting Date and ending at the earliest on the second anniversary of the Date of Grant. Notwithstanding the foregoing, unless RemCo has made a determination under **Rule ‎5.5**, if the last day of the Holding Period falls within a Closed Period, the last day of the Holding Period will be the first Dealing Day following the end of that Closed Period.

**Participating Company** means any French subsidiary of AZ within the meaning of section I of Article L225-197-2° of the French Commercial Code; provided, for the avoidance of doubt, that a company shall be a French subsidiary only if AZ holds, directly or indirectly, at least 10 per cent. of its share capital or voting rights.

**Privileged Information** means privileged information within the meaning of Article 7 of Regulation (EU) No. 596/2014 of the European Parliament and of the Council of 16 April 2014 on market abuse (Market Abuse Regulation) which has not been made public.

**Vesting Date** means in relation to an Award the date specified at the Date of Grant and determined by RemCo so that the Vesting Period shall be at least one year, save that if such date falls within a Closed Period, unless RemCo has made a determination under **Rule 5.5**, the Vesting Date will be the first Dealing Day following the end of that Closed Period.

## Exhibit 4.4

**Exhibit 4.4**

Plan Rules of the AstraZeneca Extended Incentive Plan<br> Adopted by RemCo on 31 January 2018 and amended on 22 October 2019, 25 September 2020, 27 April 2022, 13 December 2023, 3 February 2025 and 11 December 2025.<br> Plan terminates on 30 January 2028<br> Appendix 2 approved by RemCo on 23 July 2018

**AstraZeneca Extended Incentive Plan**

*<u>What is an 'award' and when do you get shares?</u>*

An award under the Plan is a contingent right to receive shares in AstraZeneca PLC. When your award 'vests' you receive shares.

Your award will normally vest as to 50% on the fifth anniversary of grant and as to the balance on the tenth anniversary of grant. After your award vests, you will receive a net number of shares after withholdings for tax have been made. However, those shares will be transferred to a nominee or custodian arrangement where they will remain, subject to the Rules of the Plan, until the tenth anniversary of grant. You will also have no right to sell the shares that you receive following the fifth anniversary of grant until the remainder of your award vests on the tenth anniversary of grant.

*<u>What happens if you leave?</u>*

Awards will generally only vest if you are employed on the vesting date. If you leave AZ within three years after grant, regardless of why you leave, your award will lapse.

If within three years after grant, you cease to be in the role in which you were in when you were granted your award, your award will lapse unless you have been requested to change your role by AZ and AZ has approved a successor to take over your role. In that case, your award will vest on the normal vesting dates, subject to its terms.

If you leave AZ between three to five years from grant, your award will lapse unless (i) you end employment for death or incapacity, in which case your award will vest on the date you cease employment, pro-rated for the time you were in employment, or (ii) you are made redundant, in which case your award will vest on the fifth anniversary of grant, subject to its terms, pro-rated for the time you were in employment, or (iii) you retire, in which case your award will vest on the fifth anniversary of grant, subject to its terms, pro-rated for the time you were in employment, but will immediately lapse if you work for a competitor. Following retirement, your shares will continue to be subject to restrictions on sale up to the tenth anniversary of grant, and will be clawed back if you work for a competitor during that period.

If you leave AZ between five to ten years from grant, your award will lapse unless (i) you end employment for death or incapacity, in which case your shares that vested on the fifth anniversary of grant will be released and your unvested award will vest on the date you cease employment, pro-rated for the time between the fifth anniversary of grant and when you leave, or (ii) you are made redundant, in which case your shares that vested on the fifth anniversary of grant will be released on the tenth anniversary of grant and your unvested award will vest on the tenth anniversary of grant, subject to its terms and pro-rated for the time between the fifth anniversary of grant and when you leave, or (iii) you retire, in which case your shares that vested on the fifth anniversary of grant will be released on the tenth anniversary of grant and your unvested award will vest on the tenth anniversary of grant, subject to its terms and pro-rated for the time between the fifth anniversary of grant and when you leave, but will immediately lapse if you work for a competitor. Following retirement, your shares will continue to be subject to restrictions on sale up to the tenth anniversary of grant, and will be clawed back if you work for a competitor during that period.

If you leave for any reason other than death, incapacity or redundancy after the fifth anniversary of grant but before the tenth anniversary of grant and work for a competitor during such period, the shares you received following the fifth anniversary of grant will be clawed back.

*<u>Change of control of AstraZeneca</u>*

If there is a change in control of AZ within three years after grant, your award will lapse.

If there is a change in control of AZ after three years after grant, your award will vest pro-rata subject to its terms.

*<u>Dividends</u>*

On vesting, your nominee or custodian arrangement will be credited with cash or additional shares to reflect any dividends that would have been paid to you had you held the shares that vest on any dividend record dates during the period beginning on the Date of Grant and ending on the date of vesting (dividend equivalents). These will be released to you following the tenth anniversary of grant.

*<u>General</u>*

Awards are personal to you and may not be transferred or charged until they vest. The awards do not form part of your terms and conditions of employment and are not pensionable.

You will be required to accept the grant of your award and agree to its terms.

This summary does not form part of the Rules of the Plan. The Rules of the Plan are set out in the following pages and will govern how your awards are treated. Definitions and interpretation provisions are at Appendix 1. If you are resident in a country outside of the UK, your award may be subject to special terms.

**Rules of the AstraZeneca Extended Incentive Plan**

**1.** **Grant of Awards** 

1.1 RemCo may approve the grant of Awards to Eligible Employees, subject to the limits in **Rule 10**.
Awards will not be granted during a Closed Period. Awards may not be granted to Eligible Employees who are resident in France until such
time as the Plan has been approved by RemCo.

**2.** **Vesting of Awards** 

2.1 Vesting of your Award is subject to such terms and conditions as RemCo considers appropriate before grant.

2.2 Unless your Award vests early under **Rules 3** or **7**, and subject to **Rule 2.4**,
your Award will vest to the extent that any terms and conditions imposed under **Rule 2.1** have been met:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.2.1 as to 50 per cent. of the Shares which are subject to Award (rounded to three decimal places) on the fifth
anniversary of the Date of Grant, and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.2.2 as to the balance of the Shares which are subject to Award on the tenth anniversary of the Date of Grant.

2.3 Any Shares that you acquire following vesting of part of your Award under **Rule 2.2.1** shall
remain subject to forfeiture if you end Employment (other than by reason of Redundancy) and work for a competitor (as determined by AZ)
before the tenth anniversary of the Date of Grant.

2.4 Notwithstanding anything else in this Plan, if the fifth or tenth anniversary of the Date of Grant falls
within a Closed Period, references to the fifth or tenth anniversary (respectively) of the Date of Grant in this Plan shall be deemed
to be references to the first Dealing Day following the end of that Closed Period (unless RemCo has made a determination under **Rule 5.8**).

**3.** **Change of role and end of Employment** 

3.1 Subject to the remainder of this **Rule 3** if you end Employment before the tenth anniversary
of the Date of Grant, your Award will lapse.

3.2 If you end your Current Role before the third anniversary of the Date of Grant, your Award will lapse,
unless you end your Current Role at the request of AZ and either your Current Role has a successor validated by SET or SET has confirmed
that no successor is necessary.

3.3 If you end Employment after the third anniversary of the Date of Grant but before the fifth anniversary
of the Date of Grant due to death or incapacity (evidenced to the satisfaction of your employing company, taking into account relevant
local legislation), your Award will vest on the date you end Employment and your Award will be reduced pro-rata to the proportion of the
relevant vesting period that has elapsed from the Date of Grant to the end of Employment.

3.4 If you end Employment as a result of Redundancy after the third anniversary of the Date of Grant but before
the fifth anniversary of the Date of Grant:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.4.1 your Award will vest on the fifth anniversary of the Date of Grant, but will be reduced pro-rata to the
proportion of the relevant vesting period that has elapsed from the Date of Grant to the end of Employment; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.4.2 your Shares will be held in the relevant nominee or similar arrangements as set out in **Rule 5.2** until the tenth anniversary of the Date of Grant.

3.5 If you end Employment as a result of Retirement after the third anniversary of the Date of Grant but before
the fifth anniversary of the Date of Grant:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.5.1 your Award will vest on the fifth anniversary of the Date of Grant, but will be reduced pro-rata to the
proportion of the relevant vesting period that has elapsed from the Date of Grant to the end of Employment, provided that your Award shall
immediately lapse if before the fifth anniversary of the Date of Grant you have started working for a competitor to AZ (as determined
by AZ); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.5.2 your Shares will be held in the relevant nominee or similar arrangements as set out in **Rule 5.2** until the tenth anniversary of the Date of Grant, and if you work for a competitor to AZ (as determined by AZ) before the tenth anniversary
of the Date of Grant, you may be required to transfer such Shares (together with any additional Shares acquired pursuant to **Rules 5.6** and **5.7**) to AZ, or a person that AZ chooses, for nil consideration.

3.6 If you end Employment after the fifth anniversary of the Date of Grant but before the tenth anniversary
of the Date of Grant due to death or incapacity (evidenced to the satisfaction of your employing company, taking into account relevant
local legislation):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.6.1 the Shares that are subject to the part of the Award that vested on the fifth anniversary of the Date
of Grant will be released from any nominee or similar arrangements on the date you end Employment; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.6.2 your Award will vest in relation to the balance of the Shares which are subject to your Award on the date
you end Employment reduced pro-rata to the proportion of the relevant vesting period that has elapsed from the fifth anniversary of the
Date of Grant to the end of Employment.

3.7 If you end Employment as a result of Redundancy after the fifth anniversary of the Date of Grant but before
the tenth anniversary of the Date of Grant:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.7.1 the Shares that are subject to the part of the Award that vested on the fifth anniversary of the Date
of Grant will be released from any nominee or similar arrangements on the tenth anniversary of the Date of Grant; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.7.2 your Award will vest in relation to the balance of the Shares which are subject to your Award on the tenth
anniversary of the Date of Grant, reduced pro-rata to the proportion of the relevant vesting period that has elapsed from the fifth anniversary
of the Date of Grant to the end of Employment.

3.8 If you end Employment as a result of Retirement after the fifth anniversary of the Date of Grant but before
the tenth anniversary of the Date of Grant:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.8.1 the Shares that are subject to the part of the Award that vested on the fifth anniversary of the Date
of Grant will be released from any nominee or similar arrangements on the tenth anniversary of the Date of Grant; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.8.2 your Award will vest in relation to the balance of the Shares which are subject to your Award on the tenth
anniversary of the Date of Grant, reduced pro-rata to the proportion of the relevant vesting period that has elapsed from the fifth anniversary
of the Date of Grant to the end of Employment,

provided that if you have started working for a competitor to AZ (as determined by AZ), your Award shall immediately lapse and you may be required to transfer such Shares (together with any additional Shares acquired pursuant to **Rules 5.6** and **5.7**) to AZ, or a person that AZ chooses, for nil consideration.

3.9 If you end Employment after the fifth anniversary of the Date of Grant but before the tenth anniversary
of the Date of Grant other than in the circumstances set out in **Rules 3.6** to **3.8**:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.9.1 to the extent that your Award has not already vested it will lapse; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.9.2 the Shares that were acquired following vesting of your Award on the fifth anniversary of the Date of
Grant will continue to be held in the relevant nominee or similar arrangements until the tenth anniversary of the Date of Grant, and if
you work for a competitor (as determined by AZ) before the tenth anniversary of the Date of Grant you may be required to transfer such
Shares (together with any additional Shares acquired pursuant to **Rules 5.6** and **5.7**) to AZ, or a person that AZ chooses,
for nil consideration.

3.10 For the purposes of this **Rule 3**, if you are on statutory family-related leave, you will not
end Employment until the earlier of the date on which you notify your employer of your intention not to return to work or the date on
which you cease to have statutory or contractual rights to return to work.

3.11 If you are resident in China and you end Employment as a result of your death, if a delay in providing
the necessary documentation will result in a breach of the Chinese State Administration of Foreign Exchange requirements, your Award shall
not be satisfied by the issue or transfer of Shares but will be satisfied by the payment of a cash sum equal to the value of the Shares
in respect of which your Award vested under **Rules ‎ 3.3** or **‎** **3.6** (converted into your relevant payroll currency at an appropriate spot rate) less deductions for Tax Liabilities.

**4.** **Lapse of Awards** 

4.1 Notwithstanding any other provision of these Rules, your Award will lapse:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.1.1 if you are declared bankrupt or are unable to hold your Award by operation of law, or you attempt to transfer,
assign, charge or dispose of your Award contrary to **Rule 12.2**;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.1.2 if you do not accept the grant of your Award within any time limits set in accordance with **Rule 12.1**;
or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.1.3 to the extent that: (i) the Award does not vest in full under **Rules 3** or **7**; or
(ii) the number of Shares which are subject to the Award is reduced under **Rule 8**.

**5.** **Consequences of Vesting of an Award** 

5.1 After vesting of your Award, the number of Shares in respect of which it has vested will, subject to you
complying with any requirements imposed under **Rules 5.2** and **6**, be transferred to you as soon as practicable.

5.2 As a condition of vesting of your Award on the fifth anniversary of the Date of Grant and delivery of
your Shares, AZ may require the Shares that are to be receivable by you following vesting of your Award on the such date (including any
additional Shares acquired pursuant to **Rules 5.6** and **5.7**) be held in such nominee or other arrangement as it may consider
appropriate until the tenth anniversary of the Date of Grant, and can require you to enter into such documentation as it may consider
appropriate in relation to these Shares.

5.3 You will have no right to sell or transfer (or assign, charge or otherwise encumber) any Shares that you
acquire following the vesting of your Award on the fifth anniversary of the Date of Grant (including any additional Shares acquired pursuant
to **Rules 5.6** and **5.7**) until the tenth anniversary of the Date of Grant, other than in connection with a change of Control
under **Rule 7.4**. Any attempt to sell, transfer, assign, charge or otherwise encumber such Shares will result in immediate forfeiture
of the Shares for no consideration and you may be required to transfer your Shares to AZ, or a person that AZ chooses, for nil consideration.

5.4 Following the tenth anniversary of the Date of Grant, your Shares may be held in any nominee or other
arrangement as AZ shall determine is appropriate and will be held on your behalf on the terms notified to you from time to time.

5.5 In the event that you end Employment, AZ can require you at any time to remove your Shares from any nominee
or other arrangement. If you do not do so within six months of the date that AZ notifies you that you must remove your Shares, AZ will
have the right, at any time, to sell or direct the sale of your Shares on your behalf at the prevailing market rate and will remit the
cash proceeds to you or to an account with a nominee or custodian on your behalf. For the avoidance of doubt, Shares in this **Rule 5.5** shall refer to Shares acquired on vesting of your Award, including pursuant to **Rule 5.7**, and any additional Shares that
are acquired by you as a result of your holding of such Shares, for example by way of reinvestment of dividends paid on such Shares (including
pursuant to **Rule 5.6**).

5.6 You will have no voting, dividend or other rights in the Shares under your Award before your Award vests
under **Rule 2.2**. Shares that you acquire under the Plan will not have the benefit of any rights that attach to those Shares
by reference to a record date that is earlier than the date when you acquired them. During the period from the fifth anniversary of the
Date of Grant to the tenth anniversary of the Date of Grant, unless RemCo determines otherwise, any dividends that are declared in relation
to Shares that you acquire following the vesting of your Award on the fifth anniversary of the Date of Grant (including any additional
Shares acquired pursuant to **Rule 5.7**) shall be reinvested in the acquisition of further Shares and those further Shares shall
be held in the same nominee or other arrangement as set out in **Rule 5.2** and will be subject to forfeiture in the same circumstances
as the Shares that you acquire following the vesting of your Award on the fifth anniversary of the Date of Grant. As a condition of vesting
of your Award on the fifth anniversary of the Date of Grant and delivery of your Shares, AZ can require you to enter into such documentation
as it may consider appropriate to give effect to this **Rule 5.6**.

5.7 To the extent that your Award vests, you may, receive an additional amount as "dividend equivalents".
Unless RemCo decides otherwise, your dividend equivalents will be calculated by reference to the dividends paid or which are payable on
the number of Shares that vest, as if those dividends had been reinvested in Shares on the relevant dividend record dates during the period
beginning on the Date of Grant and ending on the relevant date of vesting, or if your Award vests early, until the date of such vesting.
This payment will be made in Shares, subject to deductions for Tax Liabilities, after your Award has vested, but no later than 15 March after
the calendar year in which your Award has vested. Any such Shares acquired following vesting of your Award on the fifth anniversary of
the Date of Grant shall be held in the same nominee or other arrangement as set out in **Rule 5.2** and will be subject to forfeiture
in the same circumstances as the other Shares that you acquire following the vesting of your Award on the fifth anniversary of the Date
of Grant.

5.8 Notwithstanding any other provision, RemCo may, at any time, determine that your Award (including any
amounts payable under **Rules 5.6** and **5.7**) shall not be satisfied by the issue or transfer of Shares but will be satisfied
by the payment to you of a cash sum equal to the value of the Shares in respect of which your Award vests on the day of vesting (converted
into your relevant payroll currency at an appropriate spot rate) less deductions for Tax Liabilities. In the event of such determination
at the fifth anniversary of the Date of Grant, such cash payment may be subject to retention at RemCo's determination until the
tenth anniversary of the Date of Grant and in the event that you end Employment before the tenth anniversary of the Date of Grant, you
may be required to forfeit such retained sum.

**6.** **Tax** 

By accepting the Award, you indemnify AZ and your employer against any Tax Liabilities that may arise in connection with the benefits delivered under the Plan. AZ or your employer may withhold any amount and make any arrangements it considers necessary to meet any Tax Liabilities, which may include the sale on your behalf of any Shares acquired by you under the Plan. As a condition of vesting of your Award on the fifth anniversary of the Date of Grant, AZ or your employer may require you to enter into any elections in respect of tax as it considers necessary or desirable.

**7.** **Change of Control of AZ** 

7.1 This **Rule 7.1** applies if:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.1.1 an offeror (alone or with any party acting in concert with the offeror) obtains Control of AZ by making
an offer to acquire the whole of the issued ordinary share capital of AZ (or any part of it which is not owned by the offeror and any
party acting in concert with the offeror);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.1.2 the Court sanctions a compromise or arrangement affecting the Shares under section 899 of the Companies
Act 2006; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.1.3 a resolution is passed for the voluntary winding up of AZ.

7.2 Where **Rule 7.1** applies before the third anniversary of the Date of Grant, your Award will
immediately lapse in full, unless **Rule 7.6** applies.

7.3 Where **Rule 7.1** applies or is likely to apply after the third anniversary of the Date of Grant
but before the fifth anniversary of the Date of Grant, unless **Rule 7.6** applies, your Award will vest at the time of the relevant
event or most practicable earlier date, reduced pro-rata to the time which has elapsed between the Date of Grant of the Award and the
date of the relevant event.

7.4 Where **Rule 7.1** applies or is likely to apply between the fifth anniversary of the Date of
Grant and tenth anniversary of the Date of Grant, unless **Rule 7.6** applies:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.4.1 the Shares that were acquired following vesting of your Award on the fifth anniversary of the Date of
Grant (and any additional Shares acquired pursuant to **Rules 5.6** and **5.7**) will be released from any nominee or similar
arrangements at the time of the relevant event or most practicable earlier date; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.4.2 your Award will vest at the time of the relevant event or most practicable earlier date, reduced pro-rata
to the proportion of the period from the fifth anniversary of the Date of Grant to the tenth anniversary of the Date of Grant that has
elapsed up to the date of the relevant event.

7.5 RemCo will confirm the extent (if any) to which an Award will vest under **Rules 7.3** or **7.4**.
Confirmation may be before, but conditional on, the relevant event in **Rule 7.1**.

7.6 If a company obtains Control of AZ, but the shareholders of the acquiring company immediately after it
has obtained Control of AZ are substantially the same as the shareholders of AZ immediately before that event, and if the acquiring company
consents to this **Rule 7.6** applying, then your unvested Award will not lapse or vest under **Rules 7.2** to **7.4**.
Instead, it will be exchanged for a new award in respect of shares having a total Market Value being equal to the Market Value of the
Shares that are subject to your Award immediately before the exchange. The new award will be governed by the Rules, except that references
to Shares shall refer to shares in the acquiring company, and references to AZ shall refer to the acquiring company.

7.7 It shall be a condition of vesting of an Award on the fifth anniversary of the Date of Grant, that if **Rule 7.6** applies after the fifth anniversary of the Date of Grant, you shall agree to exchange your Shares acquired following
vesting of your Award on the fifth anniversary of the Date of Grant (and any additional Shares acquired pursuant to **Rules 5.6** and **5.7**), for shares in the acquiring company and that such shares shall be held until the tenth anniversary of the Date of
Grant on the same basis as your Shares were held. If you breach this **Rule 7.7**, you may be required to transfer your Shares
acquired following vesting of your Award on the fifth anniversary of the Date of Grant (including Shares acquired pursuant to **Rules 5.6** and **5.7**) to AZ, or a person that AZ chooses, for nil consideration.

**8.** **Malus and Clawback** 

Notwithstanding any other provision, Awards are subject to the Malus and Clawback Global Standard and by accepting an Award, you agree to be bound by the terms of the Malus and Clawback Global Standard.

**9.** **Amending the Plan and Awards** 

9.1 If there is a Variation in the equity share capital of AZ, the number and/or the nominal value of the
Shares over which your Award is granted will be adjusted as RemCo decides. You will be notified of any adjustment under **Rule 9.1**.

9.2 AZ can amend these Rules at any time.

9.3 AZ can adopt additional sections of these Rules applicable in any jurisdiction under which Awards
may be subject to additional and/or modified terms and conditions, taking into account any securities, exchange control or taxation laws,
which may apply to you, AZ, or any member of the AZ Group. Any additional sections must conform to the basic principles of the Plan and
must not exceed the limits set out in these Rules.

**10.** **Limit on the number of Shares which can be issued** 

10.1 Any Shares you receive on vesting will be Shares that are purchased by the Trustee in the market, and
will not be Shares that are treasury shares or are newly issued to you or the Trustee.

10.2 On any day, the maximum Market Value of Shares which may be subject to an Award proposed to be granted
to an Eligible Employee, when aggregated with the Market Value of Shares (excluding Shares acquired pursuant to **Rules 5.6** and **5.7**) already subject to Awards held by that Eligible Employee, will be 900% of the Eligible Employee's basic salary at that
time. For these purposes, the Market Value of Shares which are subject to an Award or Awards on any day shall be deemed to be the Market
Value of such Shares on that day and not the Market Value of the Shares on the Date of Grant of the relevant Award.

**11.** **Administration** 

11.1 The Plan will be administered by RemCo which will interpret and construe any provision of the Plan and
to adopt any regulations for administering the Plan and any documents it thinks appropriate. The decision of RemCo on any matter concerning
the Plan will be final and binding.

11.2 Any communication in connection with the Plan (including any award documentation) can be given electronically
by e-mail or on an online portal designed for the purpose or by personal delivery or post, (in the case of a company, to its registered
office and in the case of an individual to the individual's last known address) or by any other means which AZ and you use to communicate
with each other.

11.3 Any notice under the Plan will be given: (i) if delivered personally, at the time of delivery; (ii) if
posted, at 10.00 a.m. on the third business day after it was put into the post; or (iii) if sent by e-mail or any other form
of electronic delivery system, at the time of despatch.

**12.** **General** 

12.1 You may be required to acknowledge the grant of your Award and accept its terms, in which case AZ will
notify you of this requirement. If you fail to acknowledge any Award and accept its terms within any time period notified to you, RemCo
shall have the discretion to lapse your Award without further notice to you or to apply any additional conditions to the vesting of your
Award or Shares received on vesting of your Award as it may determine.

12.2 Your Award may not be sold, transferred, assigned, charged or otherwise encumbered or disposed of to any
person, other than to your personal representatives on your death.

12.3 Participation in the Plan is not pensionable and does not form part of your employment contract. Nothing
in the Plan or any document under it will give any person any right to participate in the Plan and the grant of an Award does not create
any right or expectation to the grant of an Award in the future. Your rights and obligations under the terms of your office or Employment
will not be affected by your participation in the Plan or any right which you may have to participate under it.

12.4 By accepting an Award under the Plan, you waive all and any rights to compensation or damages under the
Plan in consequence of any loss of rights under the Plan as a result of: (i) termination of your office or Employment with a member
of the AZ Group for any reason; or (ii) the way in which RemCo or any person to whom RemCo has delegated authority, exercises or
does not exercise any discretion under the Plan. Nothing in the Plan or in any document executed under it will give you any right to continue
in Employment or will affect the right of any member of the AZ Group to terminate your Employment without liability at any time with or
without cause.

12.5 The invalidity or non-enforceability of one or more provisions of the Plan will not affect the validity
or enforceability of the other provisions of the Plan, which will remain in full force and effect.

12.6 The Plan was adopted by RemCo on 31 January 2018 and amended on 22 October 2019, 25 September 2020,
27 April 2022, 13 December 2023, 3 February 2025, and 11 December 2025. The Plan will terminate on 30 January 2028
or at any earlier time AZ decides. Termination of the Plan will not affect your Awards.

12.7 Nothing in this Plan confers any benefit, right or expectation on a person who is not an Eligible Employee
or member of the AZ Group, and no third party has any rights under the Contracts (Rights of Third Parties) Act 1999 to enforce any term
of this Plan. This does not affect any other right or remedy of a third party which may exist.

12.8 These Rules will be governed by and construed in accordance with the law of England. You, AZ and
any member of the AZ Group submit to the jurisdiction of the English courts in relation to anything arising under the Plan. RemCo may
determine that another law will apply to the operation of the Plan outside the United Kingdom.

**Appendix 1**

**Definitions and Interpretation**

**Award** means a contingent right to acquire Shares granted or proposed to be granted under **Rule 1**;

**AZ** means AstraZeneca PLC (registered number 2723534);

**AZ Group** means AZ and any subsidiary, holding company or subsidiary of a holding company of AZ (as each term is defined in section 1159 Companies Act 2006);

**Closed Period** means a period when you are prohibited from dealing in Shares under the UK Market Abuse Regulation, the Criminal Justice Act 1993, or under any other statute, regulation or similar code to which AZ is subject or other share dealing code adopted by AZ from time to time;

**Control** shall have the meaning given in section 995 Income Tax Act 2007;

**Current Role** means the role in which you are employed by AZ at the Date of Grant of your Award;

**Date of Grant** means with respect to an Award, the date on which the Award is granted;

**Dealing Day** means a day on which the New York Stock Exchange (or, if relevant and if RemCo determines, any stock exchange nominated by RemCo on which the Shares are traded) is open for the transaction of business;

**DI** means a depositary interest issued through CREST representing a beneficial interest in an ordinary share in the capital of AZ;

**Eligible Employee** means any person (other than an Excluded Person) who at a Date of Grant is an employee of any member of the AZ Group with a proven track record in AZ of at least a year and good performance in the critical role in which they are employed;

**Employment** means employment as an employee of any member of the AZ Group;

**Excluded Person** means (i) an executive director of AZ or (ii) any person who is a "person discharging managerial responsibilities", or PDMR, for the purposes of the UK Market Abuse Regulation or any share dealing code adopted by AZ from time to time or (iii) any person that RemCo knows will become an executive director of AZ;

**Malus and Clawback Global Standard** means the malus and clawback global standard approved by RemCo and which came into effect on 1 December 2023, as amended from time to time;

**Market Value** means, in relation to an ordinary share on any day, an amount equal to the average of the middle market closing prices of a Share (as derived from the New York Stock Exchange Listings Directory) or, in the case of a DI, by reference to the average of the equivalent price of a DI as derived from the Daily Official List of the London Stock Exchange plc, in the three months preceding that day. In the event that the ordinary shares cease to be traded on the New York Stock Exchange and are admitted to trading on a replacement market, references to the New York Stock Exchange shall be construed as references to the equivalent of such replacement market. In the event that DIs cease to be traded on the Main Market of the London Stock Exchange and are admitted to trading on a replacement market, references to the London Stock Exchange shall be construed as references to such replacement market;

**Plan** means the AstraZeneca Extended Incentive Plan constituted by these Rules;

**RemCo** means the duly authorised remuneration committee of the board of directors of AZ;

**Redundancy** means redundancy within the terms of the Employment Rights Act 1996;

**Retirement** means circumstances determined by RemCo, or anyone authorised by RemCo, to be retirement;

**SET** means the senior executive team of AZ from time to time as determined by RemCo;

**Share** means a fully paid ordinary share in the capital of AZ or, where the context requires it, an equivalent number of DIs;

**Tax Liabilities** means any income tax, employee's national insurance contributions, social security charges or similar taxes or charges imposed in any jurisdiction for which AZ or any member of the AZ Group is required to account;

**Trustee** means the trustee for the time being of an employee benefit trust established by AZ;

**Variation** means a capitalisation issue, rights issue, subdivision, consolidation, reduction, or any other variation in the capital of AZ;

**You** means any Eligible Employee to whom an Award has been granted, or (where the context requires) that Eligible Employee's personal representatives, and "**your**" shall be construed accordingly.

**Interpretation**

Headings are for convenience only. Words in the singular include the plural and vice versa and words importing gender include both genders. Reference to statutory provisions include amendments, extensions or re-enactments and equivalent legislation in any country other than England, and include any regulations or subordinate legislation made under them.

**Appendix 2**

**Schedule for US Participants**

The provisions of sections 1 to 2 of this Schedule modify the Rules of the Plan in respect of any Awards granted under it to Eligible Employees who are resident in the United States.

1. The following shall be inserted as new **Rule 2.5**:

"You may be required, as a condition of the vesting of your Award, to represent and agree that, in relation to Shares you acquire under the Plan:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) you understand that such Shares are deemed to be restricted securities within the meaning of Rule 144
under the United States Securities Act of 1933 (the "Securities Act"), which may not be resold in the United States or to
a U.S. person except pursuant to an effective registration statement under the Securities Act or an exemption from the registration requirements
of the Securities Act;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) you are acquiring such Shares for investment and not with a view to distribution; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) you will not resell such Shares at any time, except to non-U.S. persons in transactions effected in accordance
with Rule 904 of Regulation S under the Securities Act (or any successor section thereto) and only after the expiration of any holding
period RemCo may require.

AZ may endorse on certificates representing Shares issued or transferred upon the vesting of an Award such legend referring to the foregoing representations or restrictions or any other applicable restrictions on resale as AZ, in its discretion, shall deem appropriate."

In the definition of "AZ Group", "subsidiary" shall be defined as any company in which AZ owns, directly or indirectly, a majority of the voting rights.

2. In **Appendix 1 (Definitions)** the definitions of "Redundancy" and "Retirement"
shall be deleted and the following definitions shall be inserted:

"**Cause** shall have the meaning set out in the relevant severance program adopted by the AZ Group from time to time, which as at the date of adoption of the Plan means: if you are terminated by the AZ Group, or if you resign in lieu of such termination, on account of dishonesty, insubordination, gross mismanagement, deliberate and premeditated acts against the interests of the AZ Group, gross or repeated violation of AZ policies, procedures, or recognized standards of behavior, commission of a felony, or misconduct related to your employment or if you refuse to make a good faith effort to bring unsatisfactory job performance to a satisfactory level;"

"**Redundancy** means a qualifying involuntary termination without cause (but excluding a termination by mutual agreement or mutual consent) entitling you to a severance payment under a severance program adopted by your U.S. employing company. Vesting under these Rules following your redundancy termination is subject always to your having met all the requirements of such severance program, including having executed a valid release of all and any claims against the AZ Group;"

"**Retirement** means:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) termination without Cause after having attained age 62 with 5 years of service;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) termination without Cause after having attained age 65 with 3 years of service; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) any other meaning as may be notified to you in writing at the time of grant of your Award;"

"**Termination by Mutual Consent** shall have the meaning set out in the relevant severance program adopted by the AZ Group from time to time, which as at the date of adoption of the Plan means: termination of employment initiated by the AZ Group where the AZ Group, in its sole discretion, has determined that you have demonstrated an inability to meet and/or perform the technical requirements and/or behavioral expectations of your job satisfactorily;"

The remaining provisions of this Schedule modify the Rules of the Plan in respect of any Awards granted under it to Eligible Employees who are US taxpayers (whether or not they are also resident in the United States).

3. **Rule 2.2** shall be deleted and replaced with the following:

"Subject to **Rules 2.4, 3, 7** and **8**, your Award will vest to the extent that any terms and conditions imposed under **Rule 2.1** have been met:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.2.1 as to 50 per cent. of the Shares which are subject to Award (rounded to three decimal places) on the fifth
anniversary of the Date of Grant, and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.2.2 as to the balance of the Shares which are subject to Award on the tenth anniversary of the Date of Grant.

For the avoidance of doubt, you shall have no rights in respect of the Shares the subject of an Award until the Award has vested. If vesting of an Award would be prohibited by a Closed Period, the day on which the Award vests will be the first Dealing Day on which such prohibition ceases to apply or, if later, the first day on which you are able to trade in the Shares after the Closed Period ceases. In any event, the latest day by which the Shares subject to an Award will be delivered to you is the US Taxpayer Payment Deadline (as defined in **Rule 5.1** (as inserted by **paragraph 4** of this **Appendix 2**))."

4. **Rule 5.1** shall be deleted and replaced with the following:

"After vesting of your Award, the Shares subject to such an Award in respect to which it has vested will, subject to you complying with any requirements imposed under **Rules 5.2** and **6**, be delivered to you as soon as practicable following the vesting of the Award, but in no event later than the end of the year in which the applicable vesting date occurs, or, if later, by the 15th day of the third month following the applicable vesting date (collectively, the "**US Taxpayer Payment Deadline**"). You will not be permitted, either directly or indirectly, to designate the year of payment."

5. **Rule 5.7** shall be deleted and replaced with the following:

"On each occasion on which your Award vests, you may, at the discretion of RemCo, receive an amount equivalent to the total dividends paid or which are payable on the number of Shares which are subject to your Award and which vest, by reference to dividend record dates during the period beginning on the Date of Grant and ending on the date of vesting. This payment will be made in Shares, subject to deductions for Tax Liabilities, after your Award has vested, but in no event later than the US Taxpayer Payment Deadline (as defined in **Rule 5.1** (as inserted by **paragraph 4** of this **Appendix 2**)). Any such Shares acquired following vesting of your Award on the fifth anniversary of the Date of Grant shall be held in the same nominee or other arrangement as set out in **Rule 5.2** and will be subject to forfeiture in the same circumstances as the Shares that you acquire following the vesting of your Award on the fifth anniversary of the Date of Grant."

6. The following shall be inserted as a new **Rule 7.8**:

"If an Award vests pursuant to this **Rule 7**, and the event described in **Rule 7** also constitutes a "change in control event" under Section 409A of the US Internal Revenue Code of 1986, as it may be amended from time to time, and all regulations, interpretations and administrative guidance issued thereunder (the "Code") or the Award is otherwise exempt from Section 409A of the Code, then the Shares subject to it in respect of which it has vested will, subject to **Rule 6**, be transferred to you as soon as practicable following

the vesting of an Award, but in no event later than the US Taxpayer Payment Deadline. If such event does not constitute a "change in control event" under Section 409A of the Code and the Award is not exempt from Section 409A of the Code, then the Award will vest on the occurrence of such event described in **Rule 7**, but shall not be delivered to you until the earlier of the vesting date under **Rule 2** or the date on which your Award vests under **Rule 3**. For the avoidance of doubt, an Award shall only become payable upon the earlier of the vesting date under **Rule 2** or the date upon which your Award vests under **Rule 3** or **Rule 7**."

7. The following shall be inserted as a new **Rule 13**:

"13. Section 409A of the Code.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.1 The compensation and benefits under the Plan are intended to be exempt from Section 409A of the Code
pursuant to the exemption applicable to "short-term deferrals" under Section 1.409A-1(b)(4) of the US Treasury Regulations,
and the Plan will be interpreted and administered in a manner consistent with that intent. To the extent any compensation and benefits
are determined not to be exempt from Code Section 409A, then the Plan will be interpreted and administered in respect of such amounts
in a manner consistent with the requirements of Section 409A of the Code. The preceding provisions, however, shall not be construed
as a guarantee by AZ of any particular tax effect to you under an Award. Payment of amounts not exempt from Code Section 409A may
only be accelerated or delayed if and to the extent that such accelerated or delayed payment is permitted under Section 409A of the
Code.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.2 References to "end of Employment", "termination of Employment" and similar terms
used in the Plan mean, to the extent necessary to comply with Section 409A of the Code, the date that you first incur a "separation
from service" within the meaning of Section 409A of the Code.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.3 Notwithstanding anything in the Plan to the contrary, if at the time of your separation from service with
AZ you are a "specified employee" as defined in Section 409A of the Code, and any payment payable under the Plan as a
result of such separation from service is required to be delayed by six months pursuant to Section 409A of the Code, then AZ will
make such payment on the date that is six months following your separation from service with AZ. The amount of such payment will equal
the sum of the payments that would have been paid to you during the six-month period immediately following your separation from service
had the payment commenced as of such date and will not include interest.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.4 No Shares issued or payments made in respect of such an Award shall be funded with any assets set aside
in a trust or other arrangement in violation of Section 409A(b)(1) of the Code. To the extent any trust is utilized in administration
of the Plan, Awards granted to Eligible Employees who are US taxpayers need not be settled by Shares held in such a trust and such Awards
do not form the basis for any claims or rights with respect to such a trust's assets.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.5 In the first taxable year in which you become a US taxpayer by reason of becoming a resident alien for
US federal income tax purposes, the Plan may be amended solely with respect to you such that the compensation and benefits under the Plan
are compliant with or exempt from Section 409A of the Code. Such amendment must be effective not later than the end of the first
year in which you become a resident alien and shall only be effective with respect to amounts that were not vested prior to the date that
you became a resident alien. For any year after the first year in which you are classified as a resident alien, this clause shall not
apply, provided that a year may again be treated as the first year in which you are classified as a resident alien if you are classified
as a resident alien in that year and have not been classified as a resident alien for the three consecutive years immediately preceding
that year. This clause will be interpreted consistent with the requirements of Section 409A of the Code, including Sections 1.409A-2(c) and
1.409A-3(h) of the US Treasury Regulations, as well as any subsequent guidance under Section 409A of the Code.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.6 Awards under the Plan that become vested while you are not subject to US federal income taxation but that
are paid at a time when you subsequently have become subject to US federal income taxation are intended to be exempt from Section 409A
of the Code. This clause will be interpreted consistent with the requirements of Section 409A of the Code, including Section 1.409A-1(b)(8)(ii) of
the US Treasury Regulations, as well as any subsequent guidance under Section 409A of the Code."

8. **Rule 3.10** shall be deleted and replaced with the following:

"For the purposes of this **Rule 3**, if you are on an authorized leave of absence pursuant to an AZ policy or a legal entitlement, you will not cease to be in Employment until the earlier of the date on which you notify your employer of your intention not to return to work or the date on which you cease to have statutory or contractual rights to return to work."

9. The following sentence shall be appended to the end of the existing **Rule 8**:

"Notwithstanding anything to the contrary, this **Rule 8** shall not apply in any jurisdiction where its enforcement would be prohibited by applicable law."

**Appendix 3**

**Schedule for Participants in China**

The provisions of this Schedule modify the Rules of the Plan in respect of any Awards granted under it to Eligible Employees who are resident in China. It was approved by RemCo on 25 July 2023.

*Vesting of Awards*

1. **Rule 3.4** shall be deleted and replaced with the following:

If you end Employment as a result of Redundancy after the third anniversary of the Date of Grant but before the fifth anniversary of the Date of Grant, your Award will vest on the date you end Employment, but will be reduced pro-rata to the proportion of the relevant vesting period that has elapsed from the Date of Grant to the end of Employment.

2. **Rule 3.5** shall be deleted and replaced with the following:

"If you end Employment as a result of Retirement after the third anniversary of the Date of Grant but before the fifth anniversary of the Date of Grant, your Award will lapse on the date you end Employment and be replaced with a phantom award which takes the form of a right to call for a cash payment calculated by reference to the Market Value of a notional Share, to vest on the fifth anniversary of the Date of Grant but reduced pro-rata to the proportion of the relevant vesting period that has elapsed from the Date of Grant to the end of Employment, provided that your replacement phantom award shall immediately lapse if before the fifth anniversary of the Date of Grant you have started working for a competitor to AZ (as determined by AZ)."

3. **Rule 3.7** shall be deleted and replaced with the following:

"If you end Employment as a result of Redundancy after the fifth anniversary of the Date of Grant but before the tenth anniversary of the Date of Grant:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.7.1 the Shares that are subject to the part of the Award that vested on the fifth anniversary of the Date
of Grant will be released from any nominee or similar arrangements on the date you end Employment and you will be required to sell your
Shares within six months of the end of Employment or AZ will in accordance with **Rule 5.5** sell or direct the sale of your Shares
on your behalf at the prevailing market rate and will remit the cash proceeds to you in accordance with applicable foreign exchange control
laws and regulations and subject to **Rule 5.8**; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.7.2 Your Award in relation to the balance of Shares will lapse on the date you end Employment and be replaced
with a phantom award which takes the form of a right to call for a cash payment calculated by reference to the Market Value of a notional
Share, to vest on the tenth anniversary of the Date of Grant but reduced pro-rata to the proportion of the relevant vesting period that
has elapsed from the fifth anniversary of the Date of Grant to the end of Employment, provided that your replacement phantom award shall
immediately lapse if before the tenth anniversary of the Date of Grant you have started working for a competitor to AZ (as determined
by AZ)."

4. **Rule 3.8** shall be deleted and replaced with the following:

"If you end Employment as a result of Retirement after the fifth anniversary of the Date of Grant but before the tenth anniversary of the Date of Grant:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.8.1 the Shares that are subject to the part of the Award that vested on the fifth anniversary of the Date
of Grant will be released from any nominee or similar arrangements on the end of Employment and you will be required to sell your Shares
within six months of the end of Employment or AZ will in accordance with **Rule 5.5** sell or direct the sale of your Shares on
your behalf at the prevailing market rate and will remit the cash proceeds to you in accordance with applicable foreign exchange control
laws and regulations and subject to **Rule 5.8**; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.8.2 Your Award in relation to the balance of Shares will lapse on the date you end Employment and be replaced
with a phantom award which takes the form of a right to call for a cash payment calculated by reference to the Market Value of a notional
Share, to vest on the tenth anniversary of the Date of Grant but reduced pro-rata to the proportion of the relevant vesting period that
has elapsed from the fifth anniversary of the Date of Grant to the end of Employment, provided that your replacement phantom award shall
immediately lapse if before the tenth anniversary of the Date of Grant you have started working for a competitor to AZ (as determined
by AZ)."

5. **Rule 3.9** shall be deleted and replaced with the following:

"If you end Employment after the fifth anniversary of the Date of Grant but before the tenth anniversary of the Date of Grant other than in the circumstances set out in **Rules 3.6** to **3.8**:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.9.1 to the extent that your Award has not already vested it will
lapse; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.9.2 you will be required to remove your Shares that were acquired following vesting of your Award on the fifth
anniversary of the Date of Grant from the relevant nominee or similar arrangement and sell your Shares within six months of the end of
Employment or AZ will in accordance with **Rule 5.5** sell or direct the sale of your Shares on your behalf at the prevailing
market rate and will remit the cash proceeds to you in accordance with applicable foreign exchange control laws and regulations and subject
to **Rule 5.8**."

6. **Rule 5.3** shall be deleted and replaced with the following:

"You will have no right to sell or transfer (or assign, charge or otherwise encumber) any Shares that you acquire following the vesting of your Award on the fifth anniversary of the Date of Grant until the tenth anniversary of the Date of Grant, other than in connection with a change of Control under **Rule 7.4** or as otherwise permitted by AZ to comply with applicable foreign exchange control laws and regulations. Any other attempt to sell, transfer, assign, charge or otherwise encumber such Shares will result in immediate forfeiture of the Shares for no consideration and you may be required to transfer your Shares to AZ, or a person that AZ chooses, for nil consideration."

*Dividends*

7. **Rule 5.5** shall be deleted and replaced with the following:

"In the event that you end Employment, AZ can require you at any time to remove your Shares from any nominee or other arrangement. If you do not do so within six months of the date that AZ notifies you that you must remove your Shares, AZ will have the right, at any time, to sell or direct the sale of your Shares on your behalf at the prevailing market rate and will remit the cash proceeds to you or to an account with a nominee or custodian on your behalf. For the avoidance of doubt, Shares in this **Rule 5.5** shall refer to Shares acquired on vesting of your Award."

8. **Rule 5.6** shall be deleted and replaced with the following:

"You will have no voting, dividend or other rights in the Shares under your Award before your Award vests under **Rule 2.2**. Shares that you acquire under the Plan will not have the benefit of any rights that attach to those Shares by reference to a record date that is earlier than the date when you acquired them. During the period from the fifth anniversary of the Date of Grant to the tenth anniversary of the Date of Grant, unless RemCo determines otherwise, any dividends that are declared in relation to Shares that you acquire following the vesting of your Award on the fifth anniversary of the Date of Grant shall be paid to you in accordance with applicable foreign exchange control laws and regulations. As a condition of vesting of your Award on the fifth anniversary of the Date of Grant and delivery of your Shares, AZ can require you to enter into such documentation as it may consider appropriate to give effect to this **Rule 5.6**."

9. **Rules 5.7** shall be deleted and replaced with the following:

"To the extent that your Award vests, you may, receive an additional amount as "dividend equivalents". Unless RemCo decides otherwise, your dividend equivalents will be calculated by reference to the dividends paid or which are payable on the number of Shares that vest. This payment will be made in cash in accordance with applicable foreign exchange control laws and regulations, subject to deductions for Tax Liabilities, after your Award has vested, but no later than 15 March after the calendar year in which your Award has vested."

## Exhibit 4.5

**Exhibit 4.5**

Plan Rules of the AstraZeneca Deferred Bonus Plan<br> Adopted by RemCo on 21 August 2006, amended on 3 February 2014, 24 July 2017, 22 October 2019, 25 September 2020, 27 April 2022, 13 December 2023, 5 February 2024, 3 February 2025, and 11 December 2025<br> Plan terminates at discretion of RemCo

**Astrazeneca Deferred Bonus Plan**

*<u>What is an 'award' and when do you get shares?</u>*

An award under the Plan is a contingent right to receive shares in AstraZeneca PLC. When your award 'vests' you receive shares. Your award represents the part of your Bonus that has been deferred into AZ shares.

Your award will normally vest a specified number of years after grant. After your award vests, you will receive a net number of shares after withholdings for tax have been made. Your shares will be transferred into a nominee or custodian arrangement for you.

*<u>What happens if you leave?</u>*

If you end employment for one of the following reasons:

(a) death,

(b) ill-health, injury or disability (in each case evidenced to the satisfaction of RemCo),

(c) redundancy (within the terms of the Employment Rights Act 1996),

(d) circumstances determined by RemCo to be retirement, or

(e) the company or business in which you are employed ceasing to be a member of the AZ group in certain circumstances,

your award will normally vest in full on its vesting date.

If you end employment before the vesting date as a result of your resignation, your award will normally vest on the vesting date, unless RemCo decides otherwise.

If you end employment before the vesting date for any other reason, your award will lapse.

*<u>Change of control of AstraZeneca</u>*

If there is a change in control of AZ, your award will normally vest in full.

*<u>Dividends</u>*

On vesting, you will receive cash or additional shares to reflect any dividends that would have been paid to you had you held the shares that vest on any dividend record dates during the Vesting Period (dividend equivalents).

*<u>General</u>*

Awards are personal to you and may not be transferred or charged until they vest. The awards do not form part of your terms and conditions of employment and are not pensionable.

You may be required to acknowledge the grant of your award and agree to certain terms.

This summary does not form part of the Rules of the DBP. The Rules of the DBP are set out in the following pages and will govern how your awards are treated. Definitions and interpretation provisions are at Appendix 1. If you are resident in a country outside of the UK, your award may be subject to special terms.

**Rules of the AstraZeneca Deferred Bonus Plan**

**1.** **Grant of Awards** 

RemCo may approve the grant of Awards to Eligible Employees. Awards will not be granted during a Closed Period.

**2.** **Vesting of Awards** 

2.1 Vesting of your Award is subject to such terms and conditions as RemCo considers appropriate before grant.

2.2 Unless your Award vests early under **Rules 3** or **7**, your Award will vest on the Vesting
Date to the extent that any terms and conditions imposed under **Rule 2.1** have been met.

**3.** **End of Employment** 

3.1 If you end Employment or have been given notice to end Employment before the Vesting Date, other than
in any of the circumstances set out in **Rules 3.2, 3.3** or **3.4**, your Award will lapse on the date you end Employment,
unless RemCo decides that you can keep your Award in full or part, in which case it will vest as determined by RemCo.

3.2 If you end Employment before the Vesting Date for one of the following reasons:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.1 death;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.2 ill-health, injury or disability (in each case evidenced to the satisfaction of RemCo);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.3 redundancy within the terms of the Employment Rights Act 1996;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.4 circumstances determined by RemCo, or anyone authorised by RemCo, to be retirement; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.5 the company by which you are employed ceasing to be a member of the AZ Group, or the part of the business
in which you are employed being transferred to a person outside the AZ Group,

your Award will vest on the Vesting Date, unless RemCo decides that it will vest before then.

3.3 If you end Employment before the Vesting Date following termination of your Employment by your employer
for a reason other than gross misconduct, breach of contract or serious shortfall in performance, and the Vesting Date of your Award would
have occurred during your contractual notice period, your Award will vest on the Vesting Date.

3.4 If you end Employment before the Vesting Date as a result of your resignation, your Award will vest on
the Vesting Date, unless RemCo decides that it will lapse on the date you end Employment or RemCo decides that it will vest on an earlier
date.

3.5 For the purposes of this **Rule 3**:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.5.1 if you are on statutory family-related leave, you will not end Employment until the earlier of the date
on which you notify your employer of your intention not to return to work or the date on which you cease to have statutory or contractual
rights to return to work; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.5.2 if you cease to be in Employment but continue to provide services to the AZ Group, RemCo can decide that
your Award will continue to be subject to these Rules. You will then be regarded as having ceased Employment when you cease to provide
services to the AZ Group.

3.6 If you are resident in China and your Employment ends as a result of your death, if a delay in providing
the necessary documentation will result in a breach of the Chinese State Administration of Foreign Exchange requirements, your Award shall
not be satisfied by the issue or transfer of Shares but will be satisfied by the payment of a cash sum equal to the value of the Shares
in respect of which your Award vested under **Rule 3.2** (converted into your relevant payroll currency at an appropriate spot
rate) less deductions for Tax Liabilities.

**4.** **Lapse of Awards** 

Notwithstanding any other provision of these Rules, your Award will lapse to the extent that (i) the Award does not vest in full under **Rules 3** or **7**; or (ii) the number of Shares which are subject to the Award is reduced under **Rule 8**.

**5.** **Consequences of Vesting of an Award** 

5.1 After vesting of your Award, the number of Shares in respect of which it has vested will, subject to **Rule 6**,
be transferred to you as soon as practicable. Your Shares may be transferred into any nominee or other custodian arrangement as AZ shall
determine is appropriate (**Shareholding Arrangement**) and will be held on your behalf on the terms notified to you from time to time.
In the case of Executive Directors, this may include arrangements to ensure compliance with such shareholding requirements following cessation
of employment as may apply from time to time.

5.2 In the event that you end Employment, unless your Shares are required by AZ to be retained in the Shareholding
Arrangement, you will be required to remove your Shares from such Shareholding Arrangement within six months of the later of (i) the
date you end Employment and (ii) the Vesting Date of your Award. If your Shares remain in the Shareholding Arrangement at the end
of that six month period, AZ will have the right, at any time, to sell or direct the sale of your Shares on your behalf at the prevailing
market rate and will remit the cash proceeds to you or to an account with a nominee or custodian on your behalf. For the avoidance of
doubt, Shares in this **Rule 5.2** shall refer to Shares acquired on vesting of your Award, including pursuant to **Rule 5.4**,
and any additional Shares that are acquired by you as a result of your holding of such Shares, for example by way of reinvestment of dividends
paid on such Shares.

5.3 You will have no voting, dividend or other rights in the Shares under your Award before the Award vests.
Shares that you acquire under the Plan will not have the benefit of any rights that attach to those Shares by reference to a record date
that is earlier than the date when you acquired them.

5.4 To the extent that your Award vests you may receive an additional amount as "dividend equivalents".
Unless RemCo decides otherwise, your dividend equivalents will be calculated by reference to the dividends paid or which are payable on
the number of Shares that vest, as if those dividends had been reinvested in Shares on the relevant dividend record dates during the Vesting
Period, or if your Award vests early, until the date of such vesting. This payment will be made in cash or Shares, subject to deductions
for Tax Liabilities, after your Award has vested.

5.5 Notwithstanding any other provision, RemCo may, at any time, determine that your Award shall not be satisfied
by the issue or transfer of Shares but will be satisfied by the payment to you of a cash sum equal to the value of the Shares in respect
of which your Award vests on the day of vesting (converted into your relevant payroll currency at an appropriate spot rate) less deductions
for Tax Liabilities.

**6.** **Tax** 

By accepting the Award, you indemnify AZ and your employer against any Tax Liabilities that may arise in connection with the benefits delivered under the Plan. AZ or your employer may withhold any amount and make any arrangements it considers necessary to meet any Tax Liabilities, which may include the sale on your behalf of any Shares acquired by you under the Plan.

**7.** **Change of Control of AZ** 

7.1 If before the Vesting Date of an Award:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.1.1 an offeror (alone or with any party acting in concert with the offeror) obtains Control of AZ by making
an offer to acquire the whole of the issued ordinary share capital of AZ (or any part of it which is not owned by the offeror and any
party acting in concert with the offeror);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.1.2 the Court sanctions a compromise or arrangement affecting the Shares under section 899 of the Companies
Act 2006; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.1.3 a resolution is passed for the voluntary winding up of AZ,

unless **Rule 7.2** applies, your Award will vest on the date of that event.

7.2 If a company obtains Control of AZ, but the shareholders of the acquiring company immediately after it
has obtained Control of AZ are substantially the same as the shareholders of AZ immediately before that event, and if the acquiring company
consents to this **Rule 7.2** applying, then your Award will not vest under **Rule 7.1**. Instead, it will be exchanged
for a new award in respect of shares having a total Market Value being equal to the Market Value of the Shares that are subject to your
Award immediately before the exchange. The new award will be governed by the Rules, except that references to Shares shall refer to shares
in the acquiring company, and references to AZ shall refer to the acquiring company.

**8.** **Malus and Clawback** 

Notwithstanding any other provision, Awards are subject to the Malus and Clawback Global Standard and by accepting an Award, you agree to be bound by the terms of the Malus and Clawback Global Standard.

**9.** **Amending the Plan and Awards** 

9.1 If there is a Variation in the equity share capital of AZ, the number and/or the nominal value of the
Shares over which your Award is granted will be adjusted as RemCo decides. You will be notified of any such adjustment.

9.2 AZ can amend these Rules at any time.

9.3 AZ can adopt additional sections of these Rules applicable in any jurisdiction under which Awards
may be subject to additional and/or modified terms and conditions, taking into account any securities, exchange control or taxation laws,
which may apply to you, AZ, or any member of the AZ Group. Any additional sections must conform to the basic principles of the Plan.

**10.** **Limit on Awards** 

10.1 Any Shares that you receive on vesting will be Shares that are purchased by the Trustee in the market,
and will not be Shares that are treasury shares or are newly issued to you or the Trustee.

10.2 The Market Value of Shares (determined at or around the date that your Bonus is confirmed) which may be
subject to your Award cannot exceed the value of your Bonus.

**11.** **Administration** 

11.1 The Plan will be administered by RemCo which will interpret and construe any provision of the Plan and
may adopt any regulations for administering the Plan and any documents it thinks appropriate. The decision of RemCo on any matter concerning
the Plan will be final and binding.

11.2 Any communication in connection with the Plan (including any award documentation) can be given electronically
via e-mail or an online portal designed for the purpose or by personal delivery or post, (in the case of a company, to its registered
office and in the case of an individual to the individual's last known address) or by any other means which AZ and you use to communicate
with each other.

11.3 Any notice under the Plan will be given: (i) if delivered personally, at the time of delivery; (ii) if
posted, at 10.00 a.m. on the third business day after it was put into the post; or (iii) if sent by e-mail or any other form
of electronic delivery system, at the time of despatch.

**12.** **General** 

12.1 You may be required to acknowledge the grant of your Award and accept its terms, in which case AZ will
notify you of this requirement. If you fail to acknowledge any Award and accept its terms within any time period notified to you, RemCo
shall have the discretion to lapse your Award without further notice to you or to apply any additional conditions to the vesting of your
Award or Shares received on vesting of your Award as it may determine.

12.2 Your Award may not be sold, transferred, assigned, charged or otherwise encumbered or disposed of to any
person, other than to your personal representatives on your death.

12.3 Participation in the Plan is not pensionable and does not form part of your employment contract. Nothing
in the Plan or any document under it will give any person any right to participate in the Plan and the grant of an Award does not create
any right or expectation to the grant of an Award in the future. Your rights and obligations under the terms of your office or Employment
will not be affected by your participation in the Plan or any right which you may have to participate under it.

12.4 By accepting an Award under the Plan, you waive all and any rights to compensation or damages under the
Plan in consequence of any loss of rights under the Plan as a result of: (i) termination of your office or Employment with a member
of the AZ Group for any reason; or (ii) the way in which RemCo or any person to whom RemCo has delegated authority, exercises or
does not exercise any discretion under the Plan. Nothing in the Plan or in any document executed under it will give you any right to continue
in Employment or will affect the right of any member of the AZ Group to terminate your Employment without liability at any time with or
without cause.

12.5 The invalidity or non-enforceability of one or more provisions of the Plan will not affect the validity
or enforceability of the other provisions of the Plan, which will remain in full force and effect.

12.6 The Plan was adopted by RemCo on 21 August 2006 and subsequently amended by RemCo on 3 February 2014,
24 July 2017, 22 October 2019, 25 September 2020, 27 April 2022, 13 December 2023, 5 February 2024, 3 February 2025,
and 11 December 2025. The Plan will terminate when RemCo decides. Termination of the Plan will not affect your Awards.

12.7 Nothing in this Plan confers any benefit, right or expectation on a person who is not an Eligible Employee
or member of the AZ Group, and no third party has any rights under the Contracts (Rights of Third Parties) Act 1999 to enforce any term
of this Plan. This does not affect any other right or remedy of a third party which may exist.

12.8 These Rules will be governed by and construed in accordance with the law of England. You, AZ and
any member of the AZ Group submit to the jurisdiction of the English courts in relation to anything arising under the Plan. RemCo may
determine that another law will apply to the operation of the Plan outside the United Kingdom.

**Appendix 1<br> Definitions and Interpretation**

**Award** means a contingent right to acquire Shares granted or proposed to be granted under **Rule 1**;

**AZ** means AstraZeneca PLC (registered number 2723534);

**AZ Group** means AZ and any subsidiary, holding company or subsidiary of a holding company of AZ (as each term is defined in section 1159 Companies Act 2006);

**Bonus** means the bonus awarded to you which is deferred into an Award;

**Closed Period** means a period when you are prohibited from dealing in Shares under the UK Market Abuse Regulation, the Criminal Justice Act 1993, or under any other statute, regulation or similar code to which AZ is subject or other share dealing code adopted by AZ from time to time;

**Control** shall have the meaning given in section 995 Income Tax Act 2007;

**Date of Grant** means with respect to an Award, the date on which the Award is granted;

**Dealing Day** means a day on which the New York Stock Exchange (or, if relevant and if RemCo determines, any stock exchange nominated by RemCo on which the Shares are traded) is open for the transaction of business;

**DI** means a depositary interest issued through CREST representing a beneficial interest in an ordinary share in the capital of AZ;

**Eligible Employee** means any person who at a Date of Grant is an employee of any member of the AZ Group or who was an employee of any member of the AZ Group during the financial year to which the Bonus relates;

**Employment** means employment as an employee of any member of the AZ Group;

**Executive Director** means any member of the board of directors of AZ from time to time who is not a non-executive director;

**Malus and Clawback Global Standard** means the malus and clawback global standard approved by RemCo and which came into effect on 1 December 2023, as amended from time to time;

**Market Value** means, in relation to an ordinary share on any day, an amount equal to the average of the middle market closing prices of a Share (as derived from the New York Stock Exchange Listings Directory) on the three consecutive Dealing Days preceding that day (or such other Dealing Day or Dealing Days as RemCo may decide) or, in the case of a DI, by reference to the average of the equivalent price of a DI as derived from the Daily Official List of the London Stock Exchange plc on trading days as close as possible to those Dealing Days. In the event that the ordinary shares cease to be traded on the New York Stock Exchange and are admitted to trading on a replacement market, references to the New York Stock Exchange shall be construed as references to the equivalent of such replacement market. In the event that DIs cease to be traded on the Main Market of the London Stock Exchange and are admitted to trading on a replacement market, references to the London Stock Exchange shall be construed as references to such replacement market;

**Plan** means the AstraZeneca Deferred Bonus Plan constituted by these Rules;

**RemCo** means the duly authorised remuneration committee of the board of directors of AZ;

**Share** means a fully paid ordinary share in the capital of AZ or, where the context requires it, an equivalent number of DIs;

**Shareholding Arrangement** means the nominee or custodian arrangement referred to in **Rule 5.1**;

**Tax Liabilities** means any income tax, employee's national insurance contributions, social security charges or similar taxes or charges imposed in any jurisdiction for which AZ or any member of the AZ Group is required to account;

**Trustee** means the trustee for the time being of an employee benefit trust established by AZ;

**Variation** means a capitalisation issue, rights issue, subdivision, consolidation, reduction, or any other variation in the capital of AZ;

**Vesting Date** means in relation to an Award the date specified at the Date of Grant, save that if such date falls within a Closed Period, unless RemCo has made a determination under **Rule 5.5**, the Vesting Date will be the first Dealing Day following the end of that Closed Period;

**Vesting Period** means in relation to an Award, the period between the Date of Grant of the Award and the Vesting Date; and

**Y** **ou** means any Eligible Employee to whom an Award has been granted, or (where the context requires) that Eligible Employee's personal representatives, and "**your**" shall be construed accordingly.

**Interpretation**

Headings are for convenience only. Words in the singular include the plural and vice versa and words importing gender include both genders. Reference to statutory provisions include amendments, extensions or re-enactments and equivalent legislation in any country other than England, and include any regulations or subordinate legislation made under them.

**Appendix 2<br> Schedule for US Participants**

The provisions of sections 1 to 5 of this Schedule modify the Rules of the Plan in respect of any Awards granted under it on or after 24 July 2017 to Eligible Employees who are resident in the United States.

1. The following shall be inserted as new **Rule 2.3**:

"You may be required, as a condition of the vesting of your Award, to represent and agree that, in relation to Shares you acquire under the Plan:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) you understand that such Shares are deemed to be restricted securities within the meaning of Rule 144
under the United States Securities Act of 1933 (the "Securities Act"), which may not be resold in the United States or to
a U.S. person except pursuant to an effective registration statement under the Securities Act or an exemption from the registration requirements
of the Securities Act;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) you are acquiring such Shares for investment and not with a view to distribution; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) you will not resell such Shares at any time, except to non-U.S. persons in transactions effected in accordance
with Rule 904 of Regulation S under the Securities Act (or any successor section thereto) and only after the expiration of any holding
period RemCo may require.

AZ may endorse on certificates representing Shares issued or transferred upon the vesting of an Award such legend referring to the foregoing representations or restrictions or any other applicable restrictions on resale as AZ, in its discretion, shall deem appropriate."

2. In the definition of "AZ Group", "subsidiary" shall be defined as any company
in which AZ owns, directly or indirectly, a majority of the voting rights.

3. **Rule 3.2.3** shall be deleted and replaced by "Redundancy".

4. In **Rule 3.2.4**, the words "circumstances determined by RemCo, or anyone authorised by
RemCo, to be retirement" shall be deleted and replaced by "Retirement".

5. In **Appendix 1 (Definitions)** the following definitions shall be inserted:

"**Redundancy** means a qualifying involuntary termination without cause (but excluding a termination by mutual agreement or mutual consent) entitling you to a severance payment under a severance program adopted by your U.S. employing company. Vesting under these Rules following your redundancy termination is subject always to your having met all the requirements of such severance program, including having executed a valid release of all and any claims against the AZ Group;"

"**Retirement** means:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) termination without cause after having attained age 62 with 5 years of service;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) termination without cause after having attained age 65 with 3 years of service; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) any other meaning as may be notified to you in writing at the time of grant of your Award;".

The remaining provisions of this Schedule modify the Rules of the Plan in respect of any Awards granted under it to Eligible Employees who are US taxpayers (whether or not they are also resident in the United States).

6. **Rule 2.2** shall be deleted and replaced with the following:

"Subject to **Rules 3, 7** and **8**, your Award will vest on the Vesting Date, to the extent that any terms and conditions imposed under **Rule 2.1** have been met. For the avoidance of doubt, you shall have no rights in respect of the Shares the subject of an Award until the Award has vested. If vesting of an Award would be prohibited by a Closed Period, the day on which the Award vests will be the first Dealing Day on which such prohibition ceases to apply or, if later, the first day on which you are able to trade in the Shares after the Closed Period ceases. In any event, the latest day by which the Shares subject to an Award will be delivered to you is the US Taxpayer Payment Deadline (as defined in **Rule 5.1** (as inserted by **paragraph 9** of this **Appendix 2**))."

7. In **Rule 3.2** the words "your Award will vest on the Vesting Date, unless RemCo decides
that it will vest before then" shall be deleted and replaced by "your Award will vest on the Vesting Date. RemCo may decide
to accelerate vesting as may be permitted under Section 409A, in which case the transfer of Shares will only be accelerated from
the Vesting Date in the limited circumstances and in the manner permissible under Section 409A".

8. **Rule 3.4** shall be deleted and replaced with the following:

"If you end Employment before the Vesting Date as a result of your resignation, your Award will vest on the Vesting Date, unless RemCo decides that it will lapse on the date you end Employment."

9. **Rule 5.1** shall be deleted and replaced with the following:

"After vesting of your Award, the Shares subject to such an Award in respect to which it has vested will, subject to **Rule 6**, be delivered to you as soon as practicable following the vesting of the Award, but in no event later than the end of the year in which the applicable vesting date occurs, or, if later, by the 15th day of the third month following the applicable vesting date (collectively, the "**US Taxpayer Payment Deadline**"). You will not be permitted, either directly or indirectly, to designate the year of payment. In the event that an Award vests by reason of Redundancy and your termination of Employment occurs in the calendar year preceding the deadline for you to execute and submit a valid release of claims (if any) required by the applicable severance program, then the year of payment will be the year of the release deadline regardless of whether you earlier submit the release. For the avoidance of doubt, an Award shall only become payable upon the earlier of the Vesting Date or the date upon which your Award vests under **Rule 3** or **Rule 7**."

"Your Shares may be transferred into any nominee or other custodian arrangement as AZ shall determine is appropriate (**Shareholding Arrangement**) and will be held on your behalf on the terms notified to you from time to time. In the case of Executive Directors, this may include arrangements to ensure compliance with such shareholding requirements following cessation of employment as may apply from time to time."

10. **Rule 5.4** shall be deleted and replaced with the following:

"To the extent that your Award vests, you will receive an amount equivalent to the total dividends paid or which are payable on the number of Shares that vest, by reference to dividend record dates during the Vesting Period, or if your Award vests early, until the date of such vesting. This payment will be made in cash or Shares, subject to deductions for Tax Liabilities, after your Award has vested, but in no event later than the US Taxpayer Payment Deadline (as defined in **Rule 5.1** (as inserted by **paragraph 9** of this **Appendix 2**))."

11. The following shall be inserted as a new **Rule 7.3**:

"If an Award vests pursuant to this **Rule 7**, and the event described in **Rule 7** also constitutes a "change in control event" under Section 409A of the US Internal Revenue Code of 1986, as it may be amended from time to time, and all regulations, interpretations and administrative guidance issued thereunder (the "Code"), then the Shares subject to it in respect of which it has vested will, subject to **Rule 6**, be transferred to you as soon as practicable following the vesting of an Award, but in no event later than the US Taxpayer Payment Deadline. If such event does not constitute a "change in control event" under Section 409A of the Code, then the Award will vest on the occurrence of such event described in **Rule 7**, but shall not be delivered to you until the date that the Award would otherwise be payable to you under the terms of the Plan."

12. The following shall be inserted as a new **Rule 13**: "13. Section 409A of the Code.

---

| | |
|:---|:---|
| "13.1 | The compensation and benefits under the Plan are intended to comply with the requirements of Section 409A of the Code, and the Plan will be interpreted and administered in a manner consistent with that intent. The preceding provision, however, shall not be construed as a guarantee by AZ of any particular tax effect to you under an Award. Payment may only be accelerated or delayed if and to the extent that such accelerated or delayed payment is permitted under Section 409A of the Code. |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.2 References to "end of Employment", "cessation of Employment", "termination
of Employment" and similar terms used in the Plan mean, to the extent necessary to comply with Section 409A of the Code, the
date that you first incur a "separation from service" within the meaning of Section 409A of the Code.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.3 Notwithstanding anything in the Plan to the contrary, if at the time of your separation from service with
AZ you are a "specified employee" as defined in Section 409A of the Code, and any payment payable under the Plan as a
result of such separation from service is required to be delayed by six months pursuant to Section 409A of the Code, then AZ will
make such payment on the date that is six months following your separation from service with AZ. The amount of such payment will equal
the sum of the payments that would have been paid to you during the six-month period immediately following your separation from service
had the payment commenced as of such date and will not include interest.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.4 No Shares issued or payments made in respect of such an Award shall be funded with any assets set aside
in a trust or other arrangement in violation of Section 409A(b)(1) of the Code. To the extent any trust is utilized in administration
of the Plan, Awards granted to Eligible Employees who are US taxpayers need not be settled by Shares held in such a trust and such Awards
do not form the basis for any claims or rights with respect to such a trust's assets.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.5 In the first taxable year in which you become a US taxpayer by reason of becoming a resident alien for
US federal income tax purposes, the Plan may be amended solely with respect to you such that the compensation and benefits under the Plan
are compliant with or exempt from Section 409A of the Code. Such amendment must be effective not later than the end of the first
year in which you become a resident alien and shall only be effective with respect to amounts that were not vested prior to the date that
you became a resident alien. For any year after the first year in which you are classified as a resident alien, this clause shall not
apply, provided that a year may again be treated as the first year in which you are classified as a resident alien if you are classified
as a resident alien in that year and have not been classified as a resident alien for the three consecutive years immediately preceding
that year. This clause will be interpreted consistent with the requirements of Section 409A of the Code, including Sections 1.409A-2(c) and
1.409A-3(h) of the US Treasury Regulations, as well as any subsequent guidance under Section 409A of the Code.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.6 Awards under the Plan that become vested while you are not subject to US federal income taxation but that
are paid at a time when you subsequently have become subject to US federal income taxation are intended to be exempt from Section 409A
of the Code. This clause will be interpreted consistent with the requirements of Section 409A of the Code, including Section 1.409A-1(b)(8)(ii) of
the US Treasury Regulations, as well as any subsequent guidance under Section 409A of the Code."

13. **Rule 3.5.1** shall be deleted and replaced with the following:

"if you are on an authorized leave of absence pursuant to an AZ policy or a legal entitlement, you will not end Employment until the earlier of the date on which you notify your employer of your intention not to return to work or the date on which you cease to have statutory or contractual rights to return to work; and"

14. The following sentence shall be appended to the end of the existing **Rule 8**:

"Notwithstanding anything to the contrary, this **Rule 8** shall not apply in any jurisdiction where its enforcement would be prohibited by applicable law."

## Exhibit 4.6

**Exhibit 4.6**

Plan Rules of the AstraZeneca Performance Share Plan 2020<br> Approved by shareholders on 29 April 2020. <br> Amended by RemCo on 25 September 2020, 3 February 2021, 27 April 2022, 13 December 2023, 5 February 2024, <br> 3 February 2025, and 11 December 2025. <br> Amendments approved by shareholders on 11 May 2021 and 11 April 2024. <br> Plan terminates on 29 April 2030. <br> [French Appendix approved by shareholders on [●] and adopted by RemCo on [●].]

**AstraZeneca Performance Share Plan 2020**

*<u>What is an 'award' and when do you get shares?</u>*

An award under the Plan is a contingent right to receive shares in AstraZeneca PLC. When your award 'vests' you receive shares.

Your award vests based on two criteria:

*time* - your award will normally vest three years after grant (five years for Senior Executives who are notified at grant that a holding period will apply to their award)

*performance* - your award will vest according to how well performance targets are met over the three year performance period

After the performance period, the Remuneration Committee (RemCo) will decide whether the performance targets were met and the number of shares you will receive. You will receive a net number of shares after withholdings for tax have been made. Your shares will be transferred into a nominee or custodian arrangement for you.

*<u>What happens if you leave?</u>*

Awards will generally only vest if you are employed. If you leave AZ within three years of grant, your unvested awards will normally lapse.

However, if you end employment for one of the following reasons:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) ill-health, injury or disability (in each case evidenced to the satisfaction of RemCo),

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) redundancy (within the terms of the Employment Rights Act 1996),

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) circumstances determined by RemCo to be retirement, or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) the company or business in which you are employed ceasing to be a member of the AZ group in certain circumstances,

your award will not lapse and either:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) it will vest (subject to achievement of the performance targets) on its normal vesting date, prorated
for the time you were in employment; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) (if RemCo decides) the award will vest at the end of employment (subject to achievement of the performance
targets at that time).

If you die, your beneficiaries/estate can choose whether your award will vest on its normal vesting date (subject to achievement of the applicable performance targets and pro-rated for the time you were in employment) or at the time of death (assuming 50% achievement of applicable performance targets and pro-rated for the time you were in employment).

If you are a Senior Executive and your employment ends more than three years after grant, your award will vest at the end of the holding period of your award (or on death, if you end employment because you have died), unless you are dismissed for gross misconduct.

*<u>Change of control of AstraZeneca</u>*

If there is a change in control of AZ, your award will vest pro-rata (subject to achievement of the performance targets).

*<u>Dividends</u>*

After vesting, you will receive cash or additional shares to reflect any dividends that would have been paid to you had you held the shares. This may be on a cumulative reinvested basis or otherwise.

*<u>General</u>*

Awards are personal to you and may not be transferred or charged until they vest. The awards do not form part of your terms and conditions of employment and are not pensionable.

You may be required to acknowledge the grant of your award and agree to its terms.

This summary does not form part of the Rules of the PSP. The Rules of the PSP are set out in the following pages and will govern how your awards are treated. Definitions and interpretation provisions are at Appendix 1. If you are resident in a country outside of the UK, your award may be subject to special terms.

**Rules of the AstraZeneca Performance Share Plan 2020**

**1.** **Grant of Awards** 

RemCo may approve the grant of Awards to Eligible Employees, subject to the limits in **Rule 10**. Awards will not be granted during a Closed Period.

**2.** **Vesting of Awards** 

2.1 Vesting of your Award is subject to performance targets selected by RemCo before grant, and any other
conditions which RemCo considers appropriate. RemCo will decide whether and how far the performance targets have been met. RemCo can amend
the performance targets under **Rule 9.1**.

2.2 Unless your Award vests early under **Rules 3** or **7**, your Award will vest on the Vesting
Date (subject to achievement of the applicable performance targets).

**3.** **End of Employment** 

3.1 If you end Employment before the Normal Vesting Date other than in any of the circumstances set out in **Rule 3.2** or **3.4**, your Award will lapse unless RemCo decides that the circumstances are sufficiently exceptional for
you to keep your Award in full or part. If RemCo exercises its discretion, your Award will vest on the Normal Vesting Date (subject to
achievement of the applicable performance targets) and will be reduced pro-rata to the proportion of the Vesting Period that has elapsed
up to the end of Employment.

3.2 If you end Employment before the Normal Vesting Date for one of the following reasons:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.1 ill-health, injury or disability (in each case evidenced to the satisfaction of RemCo);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.2 redundancy within the terms of the Employment Rights Act 1996;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.3 circumstances determined by RemCo, or anyone authorised by RemCo, to be retirement; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.4 the company by which you are employed ceasing to be a member of the AZ Group, or the part of the business
in which you are employed being transferred to a person outside the AZ Group in circumstances where the Transfer of Undertakings (Protection
of Employment) Regulations 2006 apply,

subject to **Rule 3.3** your Award will vest on the Normal Vesting Date (subject to achievement of applicable performance targets), and will be reduced pro-rata to the proportion of the Vesting Period that has elapsed up to the end of Employment.

3.3 If **Rule 3.2** applies, RemCo may:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.3.1 allow the Award to vest on the date you end Employment (subject to achievement of applicable performance
targets at that time, in the opinion of RemCo); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.3.2 if RemCo believes that exceptional circumstances warrant it, allow the Award to vest on another basis.

3.4 If you end Employment before the Normal Vesting Date due to your death, your Beneficiary may elect in
writing whether:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.4.1 your Award will vest on the Normal Vesting Date (subject to achievement of applicable performance targets),
and will be reduced pro-rata to the proportion of the Vesting Period that has elapsed up to the end of Employment; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.4.2 your Award will vest on the date you end Employment, with vesting determined on the basis that the applicable
performance targets are deemed to be met as to 50% and will be reduced pro-rata to the proportion of the Vesting Period that has elapsed
up to the end of Employment.

In the event that no election is made within 30 days of AZ requesting your Beneficiary to make such election, they will be deemed to have elected for **Rule 3.4.1** to apply.

3.5 If you are a Senior Executive and you end Employment during the Holding Period of an Award other than
as a result of your death or dismissal for Gross Misconduct, your Award will vest at the end of the Holding Period, unless RemCo decides
that your Award will vest at an earlier date.

3.6 If you are a Senior Executive and you end Employment during the Holding Period of an Award as a result
of your death, your Award will vest on the date that you end Employment.

3.7 If you are a Senior Executive and you are dismissed for Gross Misconduct, your Award will lapse with immediate
effect.

3.8 For the purposes of this **Rule 3**, if you are on statutory family-related leave, you will not
end Employment until the earlier of the date on which you notify your employer of your intention not to return to work or the date on
which you cease to have statutory or contractual rights to return to work.

3.9 If you are resident in China and you end Employment as a result of your death, if a delay in providing
the necessary documentation will result in a breach of the Chinese State Administration of Foreign Exchange requirements, your Award shall
not be satisfied by the issue or transfer of Shares but will be satisfied by the payment of a cash sum equal to the value of the Shares
in respect of which your Award vested under **Rule 3.4** (converted into your relevant payroll currency at an appropriate spot
rate) less deductions for Tax Liabilities.

**4.** **Lapse of Awards** 

4.1 Notwithstanding any other provision of these Rules, your Award will lapse:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.1.1 if you are declared bankrupt or are unable to hold your Award by operation of law, or you attempt to transfer,
assign, charge or dispose of your Award contrary to **Rule 12.2**;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.1.2 to the extent that: (i) the performance targets attached to the Award are not met in full at the
Normal Vesting Date; or (ii) the Award does not vest in full under **Rules 3** or **7**; or (iii) the number of Shares
which are subject to the Award is reduced under **Rule 8**.

**5.** **Consequences of Vesting of an Award** 

5.1 After vesting of your Award, the number of Shares in respect of which it has vested will, subject to **Rule 6**,
be transferred to you as soon as practicable. Your Shares may be transferred into any nominee or other custodian arrangement as AZ shall
determine is appropriate (**Shareholding Arrangement**) and will be held on your behalf on the terms notified to you from time to time.
In the case of Executive Directors, this may include arrangements to ensure compliance with such shareholding requirements following cessation
of employment as may apply from time to time.

5.2 In the event that you end Employment, unless your Shares are required by AZ to be retained in the Shareholding
Arrangement, you will be required to remove your Shares from such Shareholding Arrangement within six months of the later of (i) the
date you end Employment and (ii) the Vesting Date of your Award. If your Shares remain in the Shareholding Arrangement at the end
of that six month period, AZ will have the right, at any time, to sell or direct the sale of your Shares on your behalf at the prevailing
market rate and will remit the cash proceeds to you or to an account with a nominee or custodian on your behalf. For the avoidance of
doubt, Shares in this **Rule 5.2** shall refer to Shares acquired on vesting of your Award, including pursuant to **Rule 5.4**,
and any additional Shares that are acquired by you as a result of your holding of such Shares, for example by way of reinvestment of dividends
paid on such Shares.

5.3 You will have no voting, dividend or other rights in the Shares under your Award before the Vesting Date.
Shares that you acquire under the Plan will not have the benefit of any rights that attach to those Shares by reference to a record date
that is earlier than the date when you acquired them.

5.4 Unless RemCo decides otherwise, whenever a dividend is paid or payable by AZ (by reference to dividend
record dates following the Date of Grant but prior to the Vesting Date of your Award), the number of Shares subject to your Award shall
be notionally increased by such number of Shares (rounded as determined by RemCo) as is equal to:

A / B \* C, where:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· A
 is the amount of the per Share dividend paid by AZ;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· B
 is the Market Value of a Share on the date that the dividend is paid by AZ; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· C
 is the number of Shares subject to your Award, including any Shares notionally added to the
 Award pursuant to this **Rule 5.4**.

To the extent that your Award vests, the additional Shares notionally added to it pursuant to this **Rule 5.4** shall vest to the same extent. To the extent that any part of your Award lapses, the additional Shares notionally added to it pursuant to this **Rule 5.4** shall lapse to the same extent.

5.5 Notwithstanding any other provision, RemCo may, at any time, determine that your Award shall not be satisfied
by the issue or transfer of Shares but will be satisfied by the payment to you of a cash sum equal to the value of the Shares in respect
of which your Award vests on the day of vesting (converted into your relevant payroll currency at an appropriate spot rate) less deductions
for Tax Liabilities.

**6.** **Tax** 

By accepting the Award, you indemnify AZ and your employer against any Tax Liabilities that may arise in connection with the benefits delivered under the Plan. AZ or your employer may withhold any amount and make any arrangements it considers necessary to meet any Tax Liabilities, which may include the sale on your behalf of any Shares acquired by you under the Plan.

**7.** **Change of Control of AZ** 

7.1 If before the Normal Vesting Date of an Award:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.1.1 an offeror (alone or with any party acting in concert with the offeror) obtains Control of AZ by making
an offer to acquire the whole of the issued ordinary share capital of AZ (or any part of it which is not owned by the offeror and any
party acting in concert with the offeror);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.1.2 the Court sanctions a compromise or arrangement affecting the Shares under section 899 of the Companies
Act 2006; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.1.3 a resolution is passed for the voluntary winding up of AZ,

unless **Rule 7.5** applies, your Award will vest on the date of that event, to the extent decided by RemCo under **Rule 7.2**.

7.2 Where **Rule 7.1** applies or is likely to apply, an Award will vest pro-rata to the time which
has elapsed between the Date of Grant of the Award and the date of the relevant event (subject to achievement of the applicable performance
targets, in the opinion of RemCo, at the time of the relevant event or most practicable earlier date). However, RemCo may decide to take
into account any other factors it believes to be relevant in determining the extent to which an Award will vest in circumstances it considers
exceptional.

7.3 RemCo will confirm the extent (if any) to which an Award will vest under **Rule 7.2**. Confirmation
may be before, but conditional on, the relevant event in **Rule 7.1**.

7.4 If one of the events described in **Rule 7.1** occurs or is likely to occur during the Holding
Period in respect of an Award, it will vest on the date of the event (unless **Rule 7.5** applies).

7.5 If a company obtains Control of AZ, but the shareholders of the acquiring company immediately after it
has obtained Control of AZ are substantially the same as the shareholders of AZ immediately before that event, and if the acquiring company
consents to this **Rule 7.5** applying, then your Award will not vest under **Rule 7.1**. Instead, it will be exchanged
for a new award in respect of shares having a total Market Value being equal to the Market Value of the Shares that are subject to your
Award immediately before the exchange. The new award will be governed by the Rules, except that references to Shares shall refer to shares
in the acquiring company, and references to AZ shall refer to the acquiring company.

**8.** **Malus and Clawback** 

Notwithstanding any other provision, Awards are subject to the Malus and Clawback Global Standard and by accepting an Award, you agree to be bound by the terms of the Malus and Clawback Global Standard.

**9.** **Amending the Plan and Awards** 

9.1 If an event occurs which causes RemCo, acting fairly and reasonably, to believe that the performance targets
in relation to your Award are no longer appropriate, RemCo can adjust or waive the performance targets accordingly. The performance targets
cannot be adjusted so that they are more difficult to satisfy.

9.2 If there is a Variation in the equity share capital of AZ, the number and/or the nominal value of the
Shares over which your Award is granted will be adjusted as RemCo decides (acting fairly and reasonably). You will be notified of any
adjustment under **Rule 9.2**.

9.3 AZ can amend these Rules at any time, save that no amendment to the advantage of Eligible Employees
can be made to the provisions in these Rules (if any) relating to:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;9.3.1 who can be granted Awards;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;9.3.2 the Plan limit set out in **Rules 10.2** to **10.4**; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;9.3.3 the basis for determining your entitlement to and the terms of the Shares and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;9.3.4 any adjustment in the event of a Variation,

without the approval of the shareholders of AZ, except for minor amendments to benefit the administration of the Plan, to take account of a change in legislation or to obtain or maintain favourable tax, exchange control or regulatory treatment for you or Eligible Employees or for a member of the AZ Group in any jurisdiction.

9.4 AZ can adopt additional sections of these Rules applicable in any jurisdiction under which Awards
may be subject to additional and/or modified terms and conditions, taking into account any securities, exchange control or taxation laws,
which may apply to you, AZ, or any member of the AZ Group. Any additional sections must conform to the basic principles of the Plan and
must not exceed the limits set out in these Rules.

**10.** **Limit on the number of Shares which can be issued** 

10.1 Until RemCo decides otherwise, any Shares you receive on vesting will be Shares that are purchased in
the market, and will not be Shares that are treasury shares or are newly issued.

10.2 If RemCo decides that newly issued Shares will be used to satisfy Awards, no Award may be granted if the
number of Shares issued or capable of being issued pursuant to Awards granted under the Plan in the previous 10 years, when aggregated
with the number of Shares issued or capable of being issued pursuant to awards made or options granted under any other Employees' Share
Scheme in the previous 10 years, would exceed 10 per cent. of the ordinary issued share capital of AZ from time to time.

10.3 For **Rule 10.2**:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10.3.1 Shares where the right to acquire them was released, cancelled or lapsed without being exercised will
be ignored; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10.3.2 where there has been a Variation in the equity share capital of AZ between the date of issue of the Shares
and the date on which the limit is to be calculated, the number of Shares to be taken into account for the purposes of the limit will
be adjusted in such manner as RemCo (acting fairly and reasonably) considers appropriate to take account of the Variation.

10.4 The maximum Market Value of Shares (determined at the Date of Grant) which may be subject to any Award
in respect of any Eligible Employee in any financial year of AZ will be 850% of the Eligible Employee's basic salary (or, in respect of
Executive Directors, such other limit as may be approved by shareholders of AZ in the remuneration policy of AZ).

**11.** **Administration** 

11.1 The Plan will be administered by RemCo which will interpret and construe any provision of the Plan and
may adopt any regulations for administering the Plan and any documents it thinks appropriate. The decision of RemCo on any matter concerning
the Plan will be final and binding.

11.2 Any communication in connection with the Plan (including any award documentation) can be given electronically
by e-mail or on an online portal designed for the purpose or by personal delivery or post, (in the case of a company, to its registered
office and in the case of an individual to the individual's last known address) or by any other means which AZ and you use to communicate
with each other.

11.3 Any notice under the Plan will be given: (i) if delivered personally, at the time of delivery; (ii) if
posted, at 10.00 a.m. on the third business day after it was put into the post; or (iii) if sent by e-mail or any other form
of electronic delivery system, at the time of despatch.

**12.** **General** 

12.1 You may be required to acknowledge the grant of your Award and accept its terms, in which case AZ will
notify you of this requirement. If you fail to acknowledge any Award and accept its terms within any time period notified to you, RemCo
shall have the discretion to lapse your Award without further notice to you or to apply any additional conditions to the vesting of your
Award or Shares received on vesting of your Award as it may determine.

12.2 Your Award may not be sold, transferred, assigned, charged or otherwise encumbered or disposed of to any
person, other than to your personal representatives on your death.

12.3 Participation in the Plan is not pensionable and does not form part of your employment contract. Nothing
in the Plan or any document under it will give any person any right to participate in the Plan and the grant of an Award does not create
any right or expectation to the grant of an Award in the future. Your rights and obligations under the terms of your office or Employment
will not be affected by your participation in the Plan or any right which you may have to participate under it.

12.4 By accepting an Award under the Plan, you waive all and any rights to compensation
or damages under the Plan in consequence of any loss of rights under the Plan as a result of: (i) termination of your office
or Employment with a member of the AZ Group for any reason; or (ii) the way in which RemCo or any person to whom RemCo has delegated
authority, exercises or does not exercise any discretion under the Plan. Nothing in the Plan or in any document executed under it will
give you any right to continue in Employment or will affect the right of any member of the AZ Group to terminate your Employment without
liability at any time with or without cause.

12.5 The invalidity or non-enforceability of one or more provisions of the Plan will not affect the validity
or enforceability of the other provisions of the Plan, which will remain in full force and effect.

12.6 The Plan was approved by ordinary resolution of the shareholders of AZ on 29 April 2020 and adopted
by RemCo on 22 October 2019. The Plan was amended by RemCo on 25 September 2020. Further amendments to the Plan were adopted
by RemCo on 3 February 2021, 27 April 2022, 13 December 2023, 5 February 2024, 3 February 2025 and 11 December 2025
and approved by shareholders on 11 May 2021 and 11 April 2024. The Plan will terminate on 29 April 2030 or at any earlier
time AZ decides. Termination of the Plan will not affect your Awards.

12.7 Nothing in this Plan confers any benefit, right or expectation on a person who is not an Eligible Employee
or member of the AZ Group, and no third party has any rights under the Contracts (Rights of Third Parties) Act 1999 to enforce any term
of this Plan. This does not affect any other right or remedy of a third party which may exist.

12.8 These Rules will be governed by and construed in accordance with the law of England. You, AZ and
any member of the AZ Group submit to the jurisdiction of the English courts in relation to anything arising under the Plan. RemCo may
determine that another law will apply to the operation of the Plan outside the United Kingdom.

**Appendix 1**

**Definitions and Interpretation**

**Award** means a contingent right to acquire Shares granted or proposed to be granted under **Rule 1**;

**AZ** means AstraZeneca PLC (registered number 2723534);

**AZ Group** means AZ and any subsidiary, holding company or subsidiary of a holding company of AZ (as each term is defined in section 1159 Companies Act 2006);

**Beneficiary** means, following your death, your legal personal representative, executor, beneficiaries or estate (as applicable) or any one or more of them;

**Closed Period** means a period when you are prohibited from dealing in Shares under the UK Market Abuse Regulation , the Criminal Justice Act 1993, or under any other statute, regulation or similar code to which AZ is subject or other share dealing code adopted by AZ from time to time;

**Control** shall have the meaning given in section 995 Income Tax Act 2007;

**Date of Grant** means with respect to an Award, the date on which the Award is granted;

**Dealing Day** means a day on which the New York Stock Exchange (or, if relevant and if RemCo determines, any stock exchange nominated by RemCo on which the Shares are traded) plc is open for the transaction of business;

**DI** means a depositary interest issued through CREST representing a beneficial interest in an ordinary share in the capital of AZ;

**Eligible Employee** means any person who at a Date of Grant is an employee of any member of the AZ Group;

**Employees' Share Scheme** means a scheme established by AZ for encouraging or facilitating the holding of shares or debentures in AZ within the meaning of section 1166 Companies Act 2006;

**Employment** means employment as an employee or Executive Director of any member of the AZ Group;

**Executive Director** means any member of the board of directors of AZ from time to time who is not a non-executive director;

**Gross Misconduct** means a serious or persistent breach of the standards of conduct which the Award holder's employer expects of the Award holder and includes but is not limited to dishonesty, theft, physical violence, unlawful discrimination or harassment, gross negligence, serious insubordination, breach of any regulatory requirement or any AZ published code of conduct or other conduct considered by RemCo to constitute gross misconduct;

**Holding Period** means in respect of an Award, the period starting on the third anniversary of the Date of Grant and ending on the first Dealing Day after the fifth anniversary of the Date of Grant, unless RemCo sets a different period at the Date of Grant. Notwithstanding the foregoing, unless RemCo has made a determination under **Rule 5.6**, if the last day of the Holding Period falls within a Closed Period, the last day of the Holding Period will be the first Dealing Day following the end of that Closed Period;

**Malus and Clawback Global Standard** means the malus and clawback global standard approved by RemCo and which came into effect on 1 December 2023, as amended from time to time;

**Market Value** means, in relation to an ordinary share on any day, an amount equal to the average of the middle market closing prices of a Share (as derived from the New York Stock Exchange Listings Directory) on the three consecutive Dealing Days preceding that day (or such other Dealing Day or Dealing Days as RemCo may decide) or, in the case of a DI, by reference to the average of the equivalent price of a DI as derived from the Daily Official List of the London Stock Exchange plc on trading days as close as possible to those Dealing Days. In the event that the ordinary shares cease to be traded on the New York Stock Exchange and are admitted to trading on a replacement market, references to the New York Stock Exchange shall be construed as references to the equivalent of such replacement market. In the event that DIs cease to be traded on the Main Market of the London Stock Exchange and are admitted to trading on a replacement market, references to the London Stock Exchange shall be construed as references to such replacement market;

**Normal Vesting Date** means in relation to an Award the first Dealing Day after the third anniversary of the Date of Grant of that Award or, if such Dealing Day falls within a Closed Period, unless RemCo has made a determination under **Rule 5.6**, the Normal Vesting Date will be the first Dealing Day following the end of that Closed Period;

**Plan** means the AstraZeneca Performance Share Plan constituted by these Rules;

**RemCo** means the duly authorised remuneration committee of the board of directors of AZ;

**Share** means a fully paid ordinary share in the capital of AZ or, where the context requires it, an equivalent number of DIs;

**Senior Executive** means (i) an Executive Director; and/or (ii) anyone else that RemCo may determine from time to time;

**Shareholding Arrangement** means the nominee or custodian arrangement referred to in **Rule 5.1**;

**Tax Liabilities** means any income tax, employee's national insurance contributions, social security charges or similar taxes or charges imposed in any jurisdiction for which AZ or any member of the AZ Group is required to account;

**Variation** means a capitalisation issue, rights issue, subdivision, consolidation, reduction, or any other variation in the capital of AZ;

**Vesting Date** means, subject to **Rules 3.3** to **3.6**, the Normal Vesting Date of an Award, other than in the case of a Senior Executive in which case it means the end of the Holding Period for that Award;

**Vesting Period** means in relation to an Award, the period between the Date of Grant of the Award and the Normal Vesting Date; and

**You** means any Eligible Employee to whom an Award has been granted, or (where the context requires) that Eligible Employee's personal representatives, and "**your**" shall be construed accordingly.

**Interpretation**

Headings are for convenience only. Words in the singular include the plural and vice versa and words importing gender include both genders. Reference to statutory provisions include amendments, extensions or re-enactments and equivalent legislation in any country other than England, and include any regulations or subordinate legislation made under them.

**Appendix 2**

**Schedule for US Participants**

This Appendix 2 shall apply to any Awards granted to Eligible Employees who are resident in the United States of America or are US taxpayers.

The provisions of sections 1 to 6 of this Schedule modify the Rules of the Plan in respect of any Awards granted under it to Eligible Employees who are resident in the United States.

1. The following shall be inserted as new **Rule 2.3**:

"You may be required, as a condition of the vesting of your Award, to represent and agree that, in relation to Shares you acquire under the Plan:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) you understand that such Shares are deemed to be restricted securities within the meaning of Rule 144
under the United States Securities Act of 1933 (the "Securities Act"), which may not be resold in the United States or to
a U.S. person except pursuant to an effective registration statement under the Securities Act or an exemption from the registration requirements
of the Securities Act;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) you are acquiring such Shares for investment and not with a view to distribution; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) you will not resell such Shares at any time, except to non-U.S. persons in transactions effected in accordance
with Rule 904 of Regulation S under the Securities Act (or any successor section thereto) and only after the expiration of any holding
period RemCo may require.

AZ may endorse on certificates representing Shares issued or transferred upon the vesting of an Award such legend referring to the foregoing representations or restrictions or any other applicable restrictions on resale as AZ, in its discretion, shall deem appropriate."

2. In the definition of "AZ Group", "subsidiary" shall be defined as any company
in which AZ owns, directly or indirectly, a majority of the voting rights.

3. **Rule 3.2.1** shall be deleted and replaced with the following:

4. "death or ill-health, injury or disability (in each case evidenced to the satisfaction of RemCo);"

5. In **Rule 3.2.2**, the words "redundancy within the terms of the Employment Rights Act 1996"
shall be deleted and replaced by "Redundancy".

6. In **Rule 3.2.3**, the words "circumstances determined by RemCo, or anyone authorised by
RemCo, to be retirement" shall be deleted and replaced by "Retirement".

7. In **Appendix 1 (Definitions)** the following definitions shall be inserted:

"**Redundancy** means a qualifying involuntary termination without cause (but excluding a termination by mutual agreement or mutual consent) entitling you to a severance payment under a severance program adopted by your U.S. employing company. Vesting under these Rules following your redundancy termination is subject always to your having met all the requirements of such severance program, including having executed a valid release of all and any claims against the AZ Group;"

"**Retirement** means:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) termination without cause after having attained age 62 with 5 years of service;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) termination without cause after having attained age 65 with 3 years of service; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) any other meaning as may be notified to you in writing at the time of grant of your Award;".

The remaining provisions of this Schedule modify the Rules of the Plan in respect of any Awards granted under it to Eligible Employees who are US taxpayers (whether or not they are also resident in the United States).

8. **Rule 2.2** shall be deleted and replaced with the following:

"Subject to **Rules 3, 7** and **8**, your Award will vest on the Vesting Date (subject to achievement of the applicable performance targets). For the avoidance of doubt, you shall have no rights in respect of the Shares the subject of an Award until the Award has vested. If vesting of an Award would be prohibited by a Closed Period, the day on which the Award vests will be the first Dealing Day on which such prohibition ceases to apply or, if later, the first day on which you are able to trade in the Shares after the Closed Period ceases. In any event, in the case that the Award is not subject to a Holding Period, the latest day by which the Shares subject to an Award will be delivered to you is the Short-Term Deferral Deadline (as defined in **Rule 5.1** (as inserted by **paragraph 12** of this **Appendix 2**))."

9. **Rule 3.3** shall be deleted and replaced with the following: "If **Rule 3.2** applies, RemCo may:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.3.1 in the case of an Award that is not subject to a Holding Period, allow the Award to vest on the date you
end Employment (subject to achievement of applicable performance targets at that time, in the opinion of RemCo); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.3.2 if RemCo believes that exceptional circumstances warrant it, allow the Award to vest on another basis,
provided that an Award that is subject to a Holding Period shall not be capable of vesting under this **Rule 3.3** prior to the
Normal Vesting Date."

10. **Rule 3.4** shall be deleted and replaced with the following: "*Rule deleted* "

11. **Rule 3.5** shall be deleted and replaced with the following:

"If you are a Senior Executive and you end Employment during the Holding Period of an Award other than as a result of your death or dismissal for Gross Misconduct, your Award will vest at the end of the Holding Period."

12. **Rule 3.6** shall be deleted and replaced with the following:

"Notwithstanding **Rules 3.1** and **3.5**, if you are a Senior Executive and you end Employment during the Holding Period of an Award as a result of your death, your Award will vest on the date that you end Employment."

13. **Rule 5.1** shall be deleted and replaced with the following:

"In the case of an Award that is not subject to a Holding Period, the Shares subject to such an Award in respect of which it has vested will, subject to **Rule 6**, be transferred to you as soon as practicable following the vesting of the Award, but in no event later than the later of: (a) the 15th day of the third month following the end of your taxable year in which the Award vests; or (b) the 15th day of the third month following the end of AZ's taxable year in which the Award vests (collectively, the "**Short-Term Deferral Deadline**")."

"In the case of an Award that is subject to a Holding Period, the Shares subject to such an Award in respect to which it has vested will, subject to **Rule 6**, be delivered to you as soon as practicable following the vesting of the Award, but in no event later than the end of the year in which the applicable vesting date occurs, or, if later, by the 15th day of the third month following the applicable vesting date (collectively, the "**US Taxpayer Payment Deadline**"). You will not be permitted, either directly or indirectly, to designate the year of payment. In the event that an Award vests by reason of Redundancy and your termination of Employment occurs in the calendar year preceding the deadline for you to execute and submit a valid release of claims (if any) required by the applicable severance program, then the year of payment will be the year of the release deadline regardless of whether you earlier submit the release. For the avoidance of doubt, an Award shall only become payable upon the earliest of the following vesting events (i) the date that the Holding Period ends, (ii) the third anniversary of the Date of Grant if you vest and become entitled to accelerated payment under **Rules 3.2** or **3.3**, (iii) the date upon which you vest and become entitled to accelerated payment under **Rules 3.6** or Rule **7.6** or (iv) termination of the Plan pursuant to **Rule 12.6**."

"Your Shares may be transferred into any nominee or other custodian arrangement as AZ shall determine is appropriate (**Shareholding Arrangement**) and will be held on your behalf on the terms notified to you from time to time. In the case of Executive Directors, this may include arrangements to ensure compliance with such shareholding requirements following cessation of employment as may apply from time to time."

14. The **following** wording shall be added to the end of **Rule 5.5**:

"For the avoidance of doubt, RemCo shall not exercise any discretion under **Rule 5.5** which would have the effect that any payments could be made in cash or Shares other than as permitted under Section 409A of the Code."

15. The following shall be inserted as a new **Rule 7.6**:

"In the case of an Award that is subject to a Holding Period, if such Award vests pursuant to **Rule 7**, and the event described in **Rule 7** also constitutes a "change in control event" under Section 409A of the US Internal Revenue Code of 1986, as it may be amended from time to time, and all regulations, interpretations and administrative guidance issued thereunder (the "Code"), then the Shares subject to it in respect of which it has vested will, subject to Rule 6, be transferred to you as soon as practicable following the vesting of an Award, but in no event later than the US Taxpayer Payment Deadline. If such event does not constitute a "change in control event" under Section 409A of the Code, then the Award will vest on the occurrence of such event described in **Rule 7**, but shall not be delivered to you until the date that the Award would otherwise be payable to you under the terms of the Plan."

The following sentence shall be appended to the end of the existing **Rule 12.6**:

"Termination of the Plan shall only result in accelerated payment of Awards that are subject to a Holding Period if and to the extent that such accelerated payment is permitted under Section 409A of the Code."

16. The following shall be inserted as a new **Rule 13**:

"13. Section 409A of the Code.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.1 In the case of Awards that are not subject to a Holding Period, the compensation and benefits under such
Awards are intended to be exempt from Section 409A of the Code pursuant to the exemption applicable to "short-term deferrals"
under Section 1.409A-1(b)(4) of the US Treasury Regulations. Such Awards will be interpreted and administered in a manner consistent
with that intent. The preceding provision, however, shall not be construed as a guarantee by AZ of any particular tax effect to you under
an Award.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.2 In the case of Awards that are subject to a Holding Period:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) The compensation and benefits under such Awards are intended to comply with the requirements of Section 409A
of the Code, and such Awards will be interpreted and administered in a manner consistent with that intent. The preceding provision, however,
shall not be construed as a guarantee by AZ of any particular tax effect to you under an Award. Payment may only be accelerated or delayed
if and to the extent that such accelerated or delayed payment is permitted under Section 409A of the Code.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) References to "end of Employment", "cessation of Employment", "termination
of Employment" and similar terms used in the Plan mean, to the extent necessary to comply with Section 409A of the Code, the
date that you first incur a "separation from service" within the meaning of Section 409A of the Code.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Notwithstanding anything in the Plan to the contrary, if at the time of your separation from service with
AZ you are a "specified employee" as defined in Section 409A of the Code, and any payment payable under the Plan as a
result of such separation from service is required to be delayed by six months pursuant to Section 409A of the Code, then AZ will
make such payment on the date that is six months following your separation from service with AZ. The amount of such payment will equal
the sum of the payments that would have been paid to you during the six-month period immediately following your separation from service
had the payment commenced as of such date and will not include interest.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) No Shares issued or payments made in respect of such an Award shall be funded with any assets set aside
in a trust or other arrangement in violation of Section 409A(b)(1) of the Code. To the extent any trust is utilized in administration
of the Plan, Awards granted to Eligible Employees who are US taxpayers need not be settled by Shares held in such a trust and such Awards
do not form the basis for any claims or rights with respect to such a trust's assets.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.3 In the first taxable year in which you become a US taxpayer by reason of becoming a resident alien for
US federal income tax purposes, the Plan may be amended solely with respect to you such that the compensation and benefits under the Plan
are compliant with or exempt from Section 409A of the Code. Such amendment must be effective not later than the end of the first
year in which you become a resident alien and shall only be effective with respect to amounts that were not vested prior to the date that
you became a resident alien. For any year after the first year in which you are classified as a resident alien, this clause shall not
apply, provided that a year may again be treated as the first year in which you are classified as a resident alien if you are classified
as a resident alien in that year and have not been classified as a resident alien for the three consecutive years immediately preceding
that year. This clause will be interpreted consistent with the requirements of Section 409A of the Code, including Sections 1.409A-2(c) and
1.409A-3(h) of the US Treasury Regulations, as well as any subsequent guidance under Section 409A of the Code.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.4 Awards under the Plan that become vested while you are not subject to US federal income taxation but that
are paid at a time when you subsequently have become subject to US federal income taxation are intended to be exempt from Section 409A
of the Code. This clause will be interpreted consistent with the requirements of Section 409A of the Code, including Section 1.409A-1(b)(8)(ii) of
the US Treasury Regulations, as well as any subsequent guidance under Section 409A of the Code."

17. **Rule 3.8** shall be deleted and replaced with the following:

"For the purposes of this **Rule 3**, if you are on an authorized leave of absence pursuant to an AZ policy or a legal entitlement, you will not end Employment until the earlier of the date on which you notify your employer of your intention not to return to work or the date on which you cease to have statutory or contractual rights to return to work."

18. The following sentence shall be appended to the end of the existing **Rule 8**:

"Notwithstanding anything to the contrary, this **Rule 8** shall not apply in any jurisdiction where its enforcement would be prohibited by applicable law."

**Appendix 3**

**France**

1. **This Appendix 3 governs the grant of Awards to French Participants** 

This **Appendix 3** modifies the Rules of the Plan in respect of any Awards granted to participants who are French Participants.This **Appendix 3** has been drafted in order to allow Awards to benefit from the tax incentive as implemented under articles L.225-197-1 to L.225-197-3, L.22-10-59 and L.22-10-60 of the French Commercial Code, articles 80 *quaterdecies* of the French Tax Code and articles L.137-13 and L.242-1 of the French Social Security Code. The current provisions of this **Appendix 3** include the regulations currently applicable in France. AZ may however have to amend the provisions of this **Appendix 3** to take into account any new regulations that could arise in the future.

It is anticipated that Awards will be eligible for favourable tax and social security treatment in France. In the case where Awards would not benefit from the favourable tax and social security treatment in France, the French Participants are informed that they may have to bear the cost of any additional income tax arising as a result of the Award and, if requested by their employer, to reimburse their employer for any employee share of social security contributions, but not the employer social security contributions, (and any assimilated charges such as, but not limited to, the *Contribution Sociale Généralisée*).

The provisions of this **Appendix 3** may be subsequently amended if Awards appear not to be eligible for the favourable tax and social security treatment in France.

2. **Adoption of French Qualified Part** 

The Plan and authority to adopt this **Appendix 3** was approved by the shareholders of AZ on 29 April 2020, and adopted by RemCo on 22 October 2019 in compliance with the law under which AZ is incorporated. [The shareholders of AZ approved the grant of awards for a further seventy-six months from [●] 2026.]

In **Rule 1** of the Plan, the following words shall be inserted:

"No Award shall be granted under **Appendix 3**: (i) more than seventy-six months after the date for approval of the Plan by the shareholders of AZ or (ii) more than seventy-six months after a later date as may be agreed by the shareholders of AZ in general meeting from time to time."

3. **The individual limit** 

The following limits shall apply in respect of Awards granted under the Rules of the Plan to French Participants:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) an Eligible Employee may not own more than 10% of the ordinary share capital of AZ at the date an Award
is granted; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) an Eligible Employee may not own, as a result of the grant of an Award, more than 10% of the ordinary
share capital of AZ.

Only shares in AZ that have been held directly by an Eligible Employee for less than seven years are included in these percentages.

4. **Early vesting of an Award** 

**Rules 3.2** to **3.9** of the Plan shall be deleted and replaced by the following:

"If a French Participant ceases to be in Employment due to injury or disability corresponding to the second and third category as described under article L.341-4 of the French Social Security Code, the company by which the French Participant is employed ceasing to be a member of the Group or the transfer of the undertaking or part-undertaking in which the French Participant is employed to a person or body corporate outside the Group, then the French Participant's Award(s) will vest, pro-rata to the time elapsed between the Date of Grant of the Award and the date of cessation of Employment, at the Normal Vesting Date, to the extent that the performance target(s) has been met at the Normal Vesting Date. However, RemCo may permit the Award to vest immediately on cessation of Employment where that cessation occurred as a result of one of the events mentioned above and, to the extent that the performance target(s) have, in the reasonable opinion of RemCo, formed after due consideration has been paid to relevant performance indicators available at the time of cessation of Employment, been satisfied from the Date of Grant to the date of cessation of Employment.

If a French Participant dies, the French Participant's personal representatives, provided that AZ has received written confirmation that the personal representatives are legally authorised to deal with the deceased French Participant's affairs, will not have to wait until the Normal Vesting Date in order to be entitled to the Award. The personal representatives shall be allowed to ask for the transfer of the Shares within 6 months after the death of the relevant French Participant. The terms under which the Shares would be transferred to the personal representatives and the ability for the personal representatives to dispose of the Shares will be determined according to the law and regulation applicable at the date of grant of the Award.

If an Award vests before the Normal Vesting Date for any reason pursuant to the Plan, the French Participant may freely dispose of the Shares subject to it and in respect of which it has vested. However, in such circumstances, unless an Award vests following a French Participant ceasing Employment due to death, injury or disability corresponding to the second and third category as described under article L.341-4 of the French Social Security Code, the French Participant shall bear the cost of any additional income tax arising as a result of the early vesting of the Award and, if requested by their employer, will reimburse their employer for any employee share of social security contributions (and any assimilated charges such as, but not limited to, the *Contribution Sociale Généralisée*)."

5. **Payments on account of dividends** 

**Rule 5.4** of the Plan shall be deleted. No amounts shall be paid to French Participants or Directors in respect of dividends that would have been paid on the Shares that are subject to the Award during the Vesting Period.

6. **Exchange of Awards** 

**Rule 7.5** shall apply to French Participants. If there is an exchange of Awards for other awards upon a merger or a demerger realised in accordance with the applicable legislation during the Vesting Period the preferential tax and social regime would continue to apply provided that the French Participant retains the shares received until the end of the Vesting Period.

In any other cases of an exchange of Awards, the French Participant shall bear the cost of any additional income tax arising as a result of the exchange of Awards and, if requested by their employer, will reimburse their employer for any employee share of social security contributions (and any assimilated charges such as, but not limited to, the *Contribution Sociale Généralisée*).

7. **Limit on the number of shares which can be issued** 

**Rule 10.2** shall be deleted and replaced by the following:

"If RemCo decides that newly issued Shares will be used to satisfy Awards, no Award may be granted to French Participants or Directors if the number of Shares issued or capable of being issued pursuant to Awards granted under the Plan, when aggregated with the number of shares issued or capable of being issued pursuant to awards made or options granted under any other employees' share scheme, would exceed 10 per cent of the ordinary issued share capital of AZ from time to time."

This 10 per cent limit does not include:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) any Shares that have not been effectively awarded at the end of the Vesting Period; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) any Shares that are no longer subject to a Vesting Period or Holding Period.

8. **Sale restriction** 

After the Vesting Date, a French Participant or Director who is an employee of a Participating Company cannot transfer the Shares:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) Within the thirty (30) calendar days before the announcement of an interim financial report or a year-end
report that AZ is required to make public.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) At any time when the French Participant or Director is in possession of Privileged Information.

9. **Definitions** 

For the purpose of this **Appendix 3**, the following definitions will apply instead of the definitions in **Appendix 1**:

**Director** means any Président du Conseil d'Administration, Président (as far as a *société par actions simplifiée* is concerned), Directeur Général, Directeur Général Délégué or Membre du Directoire of the Participating Company.

**Eligible Employee** means any person who at a Date of Grant is in Employment with a Participating Company.

**Employment** means employment as an employee or Director of a Participating Company, though a Participating Company may decide on a case by case basis to include or exclude Directors from this **Appendix 3**.

**French Participant** means a participant in the Plan who is in Employment at a Participating Company and/or an Eligible Employee as defined in the main Rules of the Plan who is a French tax resident and is subject to French social security regulation.

**Participating Company** means any French subsidiary of AZ within the meaning of section I of Article L225-197-2° of the French Commercial Code; provided, for the avoidance of doubt, that a company shall be a French subsidiary only if AZ holds, directly or indirectly, at least 10 per cent. of its share capital or voting rights.

**Privileged Information** means privileged information within the meaning of Article 7 of Regulation (EU) No. 596/2014 of the European Parliament and of the Council of 16 April 2014 on market abuse (Market Abuse Regulation) which has not been made public.

## Exhibit 4.7

**Exhibit 4.7**

**ASTRAZENECA PLC**

**2012 SAVINGS RELATED SHARE OPTION SCHEME**

As approved by ordinary resolution of shareholders in a general meeting held on **26 April 2012 and as subsequently amended by resolution of the Remuneration Committee on 23 July 2012, 13 May 2019, and 11 December 2025**

Approval extended by ordinary resolution of shareholders in a general meeting held on 29 April 2022 until the Company's annual general meeting in 2032

**HMRC Approval – 20 August 2012**

**HMRC Ref – SRS109109**

**ASTRAZENECA PLC 2012 SAVINGS RELATED SHARE OPTION SCHEME**

**1.** **DEFINITIONS** 

1.1 In this Scheme, unless the context otherwise requires, the following
words and expressions shall have the following meanings, namely:

***the Act*** means the Income Tax (Earnings and Pensions) Act 2003;

***Associated Company*** means an associated company of the Company within the meaning given to those words by paragraph 47(1) of Schedule 3 and/or paragraph 35(4) of Schedule 3, as the case may be;

***the Board*** means the board of directors of the Company or a duly authorised committee thereof;

***the Bonus Date*** means in relation to an Option the earliest date on which a bonus is payable under the terms of the relevant Savings Contract, or would be payable but for the relevant bonus rate being zero, being:

(a) where the Option is linked to a three year Savings Contract, the earliest date on which the bonus is payable
under that Savings Contract (that is, after making 36 monthly contributions);

(b) where the Option is linked to a five year Savings Contract, the earliest date on which the five year bonus
is payable under that Savings Contract (that is, after making 60 monthly contributions).

***Capital Reorganisation*** means any variation in the Share capital of the Company (including, without limitation, by way of capitalisation issue, rights issue, subdivision, consolidation or reduction);

***the Company*** means ASTRAZENECA PLC (registered in England and Wales with number 2723534);

***Continuous Service*** has the same meaning as ***continuous employment*** in the Employment Rights Act 1996;

***Control*** has the meaning given to that word by section 719 of the Act;

***the Date of Grant*** means the date on which an Option is granted;

***Dealing Day*** means any day on which the New York Stock Exchange (or, if relevant and if RemCo determines, any stock exchange nominated by RemCo on which the Shares are traded) is open for the transaction of business;

***DI*** means a depositary interest issued through CREST representing a beneficial interest in an ordinary share in the capital of the Company;

***Eligible Employee*** means:

(a) any individual who, at the Invitation Date:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) is an employee or director of one or more Participating Companies, who in the case of a director is required
under the terms of their employment to devote at least 25 hours each week (excluding meal breaks) to their duties;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) has earnings from the office or employment referred to in (i) above that meet (or would meet if there
were any) the requirements set out in paragraphs 6(2)(c) and 6(2)(ca) of Schedule 3; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) has been in Continuous Service with one or more Participating Companies for such period as the Board may
determine (not exceeding five years) prior to the Grant Date; and

(b) any other individual who, at the Invitation Date, is an employee or director of one or more Participating
Companies and who is nominated by the Board (or falls within a category of individuals nominated by the Board) as eligible to participate
in the Scheme in respect of any one or more grants of Options;

***Employee Data Privacy Notice*** means the notice referring to this Scheme, made available through the Company's intranet and/or HR system, which sets out how personal data relating to Eligible Employees and Option Holders will be processed in connection with the Scheme;

***Exercise Price*** means the price per Share payable on the exercise of an Option as determined by the Board (subject to adjustment under rule 12) but which shall not be less than:

(a) 80 per cent. (or such other percentage as may be permitted by Schedule 3) of the average Market Value
for a Share over the three consecutive Dealing Days immediately preceding the Invitation Date (rounded up to the nearest whole penny);
and

(b) in the case of any Option under which Shares may be issued, the nominal value of a Share;

***Grant Period*** means the period of 42 days commencing on any of the following:

(a) the date on which the extension of the Scheme is approved by shareholders in general meeting;

(b) the day immediately following the day on which the Company makes an announcement of its results for the
last preceding financial year, half year or other period;

(c) any day on which the Board resolves that exceptional circumstances exist which justify the grant of Options;
or

(d) any day on which any change to the legislation affecting savings-related share option schemes which comply
with Schedule 3 is proposed or made;

***the Group*** means the Company and the Subsidiaries and ***member of the Group*** shall be construed accordingly;

***HMRC*** means Her Majesty's Revenue & Customs;

***the Invitation Date*** means the date on which an invitation to apply for an Option is issued;

***Market Value*** means in relation to a Share on any day:

(a) an amount equal to the middle market closing price of a Share (as derived
from the New York Stock Exchange Listings Directory) on that day (or such other Dealing Day or Dealing Days as RemCo may decide) or, in the case of a DI, by reference to the equivalent price of a DI as derived from the Daily Official List of the London Stock Exchange
plc on the trading day as close as possible to that Dealing Day. In the event that the ordinary shares cease to be traded on the New York
Stock Exchange and are admitted to trading on a replacement market, references to the New York Stock Exchange shall be construed as references
to the equivalent of such replacement market. In the event that DIs cease to be traded on the Main Market of the London Stock Exchange
and are admitted to trading on a replacement market, references to the London Stock Exchange shall be construed as references to such
replacement market; or

(b) subject to (a) above, its market value as determined in accordance with Part VIII of the Taxation
of Chargeable Gains Act 1992 (ignoring for such purposes any Restriction applying to the Share) and agreed in advance with the Shares
and Assets Valuation division of HMRC (or any replacement body or authority thereof),

provided always that in the event that the Shares are subject to any Restriction, the market value of a Share shall be determined as though they were not subject to the Restriction;

***Minimum Amount*** means the amount of the monthly contribution to be paid under the Savings Contract being not less than £5 or such other minimum amount as may be permitted under paragraph 25 of Schedule 3 from time to time;

***Option*** means a right granted under the Scheme to subscribe for or purchase Shares;

***Option Holder*** means any individual who holds a subsisting Option (including, where the context permits, the legal personal representatives of a deceased Option Holder);

***Participating Company*** means the Company and each Subsidiary which has been nominated by the Board as a Participating Company for the purposes of the Scheme;

***Restriction*** means in relation to a Share, any restriction within the meaning of paragraph 48(3) of Schedule 3;

***Savings Contract*** means a contract under a certified SAYE savings arrangement, within the meaning of paragraph 24 of Schedule 3, approved by HMRC for the purpose of Schedule 3, the terms of which must be the same for each participant;

***Section 409A*** means Section 409A of the US Internal Revenue Code of 1986, as amended;

***Schedule 3*** means Schedule 3 to the Act;

***the Scheme*** means this Scheme as amended from time to time;

***Share Option Scheme*** means any employee share option scheme established by the Company;

***Shares*** means fully paid and irredeemable ordinary shares in the capital of the Company, which comply with the conditions in paragraphs 17 to 22 of Part 4 of Schedule 3 or, where the context requires it, an equivalent number of DIs;

***Subsidiary*** means any subsidiary of the Company within the meaning of section 1159 of and Schedule 6 to the Companies Act 2006 over which the Company has Control;

***Trustee*** means the trustees or trustee for the time being of any employee share trust established by the Company from time to time;

***UK MAR*** mean the European Union Market Abuse Regulation (596/2014/EU) on market abuse as it forms part of domestic law by virtue of the European Union (Withdrawal) Act 2018 or any equivalent or successor legislation;

***US Tax*** means taxation under the rules of the United States of America;

***US Taxpayer*** means a person who is subject to US Tax.

1.2 Where the context permits the singular shall include the
plural and vice versa. Headings shall be ignored in construing the Scheme.

1.3 References to:

(a) any act of Parliament; or

(b) any Extra-Statutory Concession published by the Board of HMRC

shall include any modification, amendment or re-enactment thereof.

**2.** **INVITATION FOR OPTIONS** 

2.1 The Board may, during a Grant Period, invite all Eligible Employees to apply for Options at the Exercise Price, provided that no invitations may be made during a period when the Company is prohibited from making invitations under UK MAR, the Criminal Justice Act 1993, any dealing restrictions under the Financial Conduct Authority's Listing Rules, or under any other statute, regulation or similar code to which the Company is subject or other share dealing code adopted by the Company from time to time.

2.2 Subject to the specific provisions contained in the Scheme, the Board may determine the form, manner and timing of invitations to apply for Options, the number of Shares in respect of which invitations are made on any date and whether the Options will be three or five year Options (or any of them, at the election of Eligible Employees). The invitation may either state the Exercise Price or (provided a mechanism exists by which the Exercise Price will be determined by the Date of Grant) invite applications by reference to amounts of monthly savings.

**3.** **APPLICATION FOR OPTIONS** 

3.1 If an Eligible Employee wishes to apply for an Option they must, within such period (which shall not be less than 14 days) after the Invitation Date as is stated in the invitation, deliver to the Company (or its appointed agent) a duly completed form of application together with a duly completed application for a Savings Contract in the form prescribed by the Board on which the Eligible Employee must have indicated the Bonus Date on which they intend to apply for repayment thereunder.

3.2 The application for an Option shall be deemed to be for an Option over the largest whole number of Shares which can be acquired at the Exercise Price with the expected repayment, including any relevant bonus, under the related Savings Contract at the appropriate Bonus Date.

3.3 The Board may treat all late applications as valid provided they are received no less than two days prior to the Date of Grant.

**4.** **SCALING DOWN** 

4.1 If valid applications are received for Options over a number of Shares in excess of that which the Board has determined to make available on a particular occasion or in excess of any limitation under rule 7, the Board may scale down applications in accordance with the following successive steps (or such other method as may be determined by the Board at any time prior to the Date of Invitation) to the extent necessary to eliminate the excess:

(a) unless paragraph 4.1(b) applies, the amount of the monthly savings contribution chosen by each applicant
shall be taken as reduced pro rata to the extent necessary, but not to less than the Minimum Amount;

(b) the amount of any monthly savings contribution chosen by an applicant which exceeds such amount as the
Board shall determine (not being less than the Minimum Amount) shall be taken as reduced to such amount;

(c) if the repayment under the Savings Contract would otherwise be taken as including a bonus, it should be
taken as not including a bonus; and

(d) applications will be selected by lot, each based on a monthly savings contribution of the Minimum Amount
and the inclusion of no bonus in the repayment under the Savings Contract.

4.2 If the number of Shares available is insufficient to enable an Option based on monthly savings contributions of the Minimum Amount and the inclusion of no bonus in the repayment under the Savings Contract to be granted to each Eligible Employee making a valid application, the Board may, as an alternative to selecting by lot, determine that no Options shall be granted on that occasion.

4.3 If applications are scaled down, the monthly contributions under Savings Contracts which Eligible Employees have chosen shall, where necessary, be scaled down as appropriate.

4.4 If, in applying the scaling down provisions contained in rule 4.1, the Board considers that it would be administratively impracticable for Options to be granted within the 30 day period referred to in rule 5.1, the Board may extend that period by not more than twelve days.

**5.** **GRANT OF OPTIONS** 

5.1 The Board may, subject to any scaling down, on a single date which shall not be later than the 30<sup>th</sup> day after the earliest date by reference to which the Exercise Price was calculated, grant all (but not some of) the Options for which valid application has been made by Eligible Employees (provided that they remain Eligible Employees on the Date of Grant).

5.2 As soon as practicable after the Date of Grant, the Board shall procure the issue of an Option certificate to each Option Holder.

5.3 Options shall be granted in consideration of Eligible Employees agreeing to enter into Savings Contracts. No cash payment shall be made for the grant of an Option.

5.4 No Option shall be granted under the Scheme after the Company's annual general meeting in 2032.

5.5 Every Option granted hereunder shall be personal to the Option Holder and, except to the extent necessary to enable a personal representative to exercise the Option following the death of an Option Holder, neither the Option nor the benefit thereof may be transferred, assigned, charged or otherwise alienated. Any transfer of an Option otherwise than as permitted under this rule 5.5 shall cause the Option to lapse.

5.6 At the Date of Grant of an Option, it must be stated (and subsequently recorded in the Option certificate relating to the Option in question) whether or not the Shares which may be acquired on the exercise of the Option may be subject to any Restriction and details of any such Restriction must also be stated (and subsequently recorded in the Option certificate relating to the Option in question).

5.7 No Options may be granted during a period when the Company is prohibited from granting Options under UK MAR, the Criminal Justice Act 1993, or under any other statute, regulation or similar code to which the Company is subject or other share dealing code adopted by the Company from time to time.

**6.** **INDIVIDUAL LIMIT** 

6.1 No individual shall be granted an Option if the entry into the related Savings Contract would result in the monthly contributions under that Savings Contract, when added to the sum of their monthly contributions under any other subsisting Savings Contracts and if the Board so determines from time to time, under any cancelled Savings Contracts, exceeding £500 (or such greater amount as is for the time being permitted under paragraph 25(3) of Schedule 3 and approved by the Board).

**7.** **SCHEME LIMITS** 

7.1 No Option to subscribe for Shares shall be granted if the result of that grant would be that the aggregate number of Shares that could be issued on the exercise of that Option and any other Options granted at the same time, when added to the number of Shares that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) could be issued on the exercise of any other subsisting share options granted during the preceding ten
years under the Scheme or any other Share Option Scheme; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) have been issued on the exercise of any share options granted during the preceding ten years under the
Scheme or any other Share Option Scheme; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) have been issued during the preceding ten years under any profit sharing or other employee share incentive
plan (not being a Share Option Scheme),

would exceed 10 per cent. of the ordinary share capital of the Company for the time being in issue.

7.2 Reference in this rule 7 to the ***issue*** of Shares shall, for the avoidance of doubt, mean the issue and allotment (but not transfer) of Shares. Where Shares are or will be allotted or issued to the Trustee for the purpose of satisfying Options by way of a transfer of Shares by the Trustee, such Shares should be treated as issued or capable of being issued for the purpose of this rule 7.

7.3 Shares that are treasury shares held by the Company in accordance with section 724 to section 732 of the Companies Act 2006 should be treated as issued or capable of being issued for the purpose of this rule 7 for so long as such approach is recommended by institutional shareholders.

**8.** **EXERCISE AND LAPSE OF OPTIONS** 

8.1 Save as otherwise permitted under these rules, an Option may only be exercised:

(a) during the six months following the Bonus Date relating to it; and

(b) by an Option Holder who is, at the date of exercise, a director or employee of a Participating Company,

and, if not exercised, shall lapse at the end of the six month period following the Bonus Date.

8.2 Where an Option Holder ceases to be a director or employee of a Participating Company before the expiry of six months after the Bonus Date:

(a) on retirement or by reason of redundancy (within the meaning of the Employment Rights Act 1996), injury
or disability, or a relevant transfer within the meaning of the Transfer of Undertakings (Protection of Employment) Regulations 2006,
they may exercise any outstanding Options within six months of the date on which their employment ceased, failing which exercise the Options
shall lapse automatically, provided that the Options may not be exercised more than six months following the relevant Bonus Date;

(b) on:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) their employing company ceasing to be under the Control of the Company; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the business (or part of a business) in which they are employed being transferred to a person who is neither
an Associated Company nor a company over which the Company has Control which is not a relevant transfer within the meaning of the Transfer
of Undertakings (Protection of Employment) Regulations 2006,

they may exercise any outstanding Options within six months of the date on which their employment ceased, failing which exercise the Options shall lapse automatically, provided that the Options may not be exercised more than six months following the relevant Bonus Date;

(c) for any other reason other than dismissal for gross misconduct, breach of contract or serious shortfall
in performance, they may exercise any outstanding Options which were granted more than three years before the date of cessation of employment
within six months of the date on which their employment ceased, failing which exercise the Options shall lapse automatically, provided
that the Options may not be exercised more than six months following the relevant Bonus Date; or

(d) in any circumstances other than those set out in rules 8.2(a), 8.2(b) and 8.2(c) and rule 8.3,
their Options shall lapse automatically.

8.3 If an Option Holder dies while in service or at any time after leaving service when they hold an Option, such Options may be exercised by their personal representatives at any time within the twelve month period following:

(a) the date of death, if such death occurred before the relevant Bonus Date; and

(b) the Bonus Date, in the event of their death within six months after the relevant Bonus Date,

failing which exercise, the Options shall lapse automatically. For the avoidance of doubt, an Option exercisable under this rule 8.3 shall not lapse prior to the expiry of the specified twelve month period by virtue of rule 8.2 or rule 10.

8.4 For the purposes of rule 8.2, an Option Holder shall not be treated as ceasing to be a director or employee of a Participating Company until:

(a) they cease to hold an office or employment in the Company or any company over which the Company has Control
or any Associated Company;

(b) they cease to hold an office or employment in a jointly owned company within the meaning of paragraph
46 of Schedule 3 (being a jointly owned company which is not a participating company in more than one group scheme); or

(c) being on statutory family-related leave, the Option Holder notifies their employer of their intention
not to return to work or ceases to be entitled to exercise any statutory or contractual right to return to work.

8.5 Notwithstanding rule 8.1(b), if, at the Bonus Date, an Option Holder holds an office or employment in a company which is not a Participating Company but is an Associated Company or a company over which the Company has Control, Options may be exercised within (but no later than) six months following the Bonus Date.

8.6 If, before the Option has become exercisable, the Option Holder:

(a) gives notice, or is deemed to have given notice, under the terms of the related Savings Contract that
they intend to stop paying contributions to that Savings Contract; or

(b) makes an application for repayment of the related Savings Contract, the Option shall
automatically lapse.

8.7 If an Option Holder is declared bankrupt or enters into any general composition with or for the benefit of their creditors including a voluntary arrangement under the Insolvency Act 1986, their Options shall automatically lapse.

8.8 This rule shall apply to US Taxpayers. Notwithstanding anything to the contrary contained in this Scheme: (a) if such Option is vested (within the meaning of Section 409A) in the year the Option Holder becomes a US Taxpayer, such Option shall be exercisable only within the shorter of any exercise period specified in the rules of this Scheme and the expiry of two and a half calendar months after the end of the calendar year in which the Option Holder becomes a US Taxpayer, and (b) if such Option is not vested (within the meaning of Section 409A) in the year the Option Holder becomes a US Taxpayer, such Option shall be exercisable only within the shorter of any exercise period specified in the rules of this Scheme and the expiry of two and a half calendar months after the end of the calendar year in which the substantial risk of forfeiture (within the meaning of Section 409A) lapses.

**9.** **METHOD AND EXTENT OF EXERCISE** 

9.1 An Option may only be exercised with monies as nearly as possible equal to but not exceeding the amount repaid under the related Savings Contract, including any bonus or interest as at the date of repayment. No account shall be taken of any repayment of any contribution the due date of which arises after the date of repayment, or any bonus or interest in respect of that contribution.

9.2 An Option Holder may exercise their Option on one occasion only, in whole or in part, by giving notice in writing to the Company or to such other person (including, for the avoidance of doubt, the Trustee), as the Company may direct in the prescribed form specifying the number of Shares in respect of which the Option is being exercised and enclosing payment in full of the aggregate Exercise Price of those Shares together with evidence of closure of the related Savings Contract. The date of exercise shall be the date of receipt by the Company (or such other person as the Company may direct) of the notice of exercise. If the Option is exercised in respect of some only of the Shares comprised in the Option, the Option in respect of the balance shall thereupon lapse automatically.

9.3 An Option Holder may not exercise their Option at any time when that exercise would be in breach of UK MAR, the Criminal Justice Act 1993, or any other statute, regulation or similar code to which the Company is subject or other share dealing code adopted by the Company from time to time.

**10.** **GENERAL OFFER FOR THE COMPANY ETC.** 

10.1 If any person (either alone or together with any person acting in concert with them) makes a general offer to acquire the whole of the issued ordinary share capital of the Company (other than those shares which are already owned by them and/or any person acting in concert with them), the Company shall, as soon as reasonably practicable thereafter (and prior to the date on which the offer becomes or is declared unconditional in all respects) give notice to each Option Holder of such general offer and each Option Holder may exercise their Options within the period of one month (or such longer period as the Board may permit, but not longer than six months) following the date on which the relevant person has obtained control of the Company and any condition subject to which the offer is made has been satisfied PROVIDED THAT an Option may not be exercised more than six months after the relevant Bonus Date. For the purposes of this rule 10.1, it does not matter if the general offer is made to different shareholders by different means.

Failing any permitted exercise, the Options shall, without prejudice to the operation of rule 11, lapse automatically (unless the Board determines otherwise) upon the expiry of the six month period PROVIDED THAT if an event as described in rule 10.2 occurs during the six month period, the period during which the Options may be exercised shall be the shorter of the periods specified under this rule 10.1 and rule 10.2 SAVE THAT the Board may, if it so determines, at the time it gives notice to each Option Holder of any general offer, notify each Option Holder that Options shall not lapse at the end of the six month period referred to above but shall instead continue to subsist at the end of the period and thereafter be subject to the rules of the Scheme in the normal way.

**Compulsory Acquisition**

10.2 If any person becomes bound or entitled to give a notice under section 979 to section 982 of the Companies Act 2006 to acquire Shares; each Option Holder may exercise their Options at any time during the period when that person remains so bound or entitled PROVIDED THAT an Option may not be exercised more than six months after the relevant Bonus Date.

Failing any permitted exercise the Options shall, without prejudice to the operation of rule 11, lapse automatically upon the expiry of the relevant period.

**Scheme of Arrangement**

10.3 If under section 899 of the Companies Act 2006 the court sanctions a compromise or arrangement applicable to or affecting either: (i) all the ordinary share capital of the Company or all the shares of the same class as the Shares subject to Options; or (ii) all of the shares, or all of the shares of that same class, which are held by a class of shareholders identified otherwise than by reference to their employment or directorships or their participation in a scheme that meets the requirements of Schedule 3, any outstanding Options may be exercised within six months of the court sanctioning the compromise or arrangement, failing which exercise the Options shall, without prejudice to the operation of rule 11 lapse automatically PROVIDED THAT an Option may not be exercised more than six months after the relevant Bonus Date.

**Voluntary Winding-up**

10.4 If notice is duly given of a resolution for a voluntary winding-up of the Company then an Option Holder may exercise their Options within the period of two months from the date of the resolution, failing which exercise the Options shall lapse automatically.

**20 day Grace Period**

10.5 This rule 10.5 shall only apply in relation to Options granted after 13 May 2019. If a relevant event within paragraph 37(6C) of Schedule 3 occurs and as a consequence of such event, the Shares to which Options relate no longer meet the requirements of Part 4 of Schedule 3, an Option Holder may only exercise their Options then held by them pursuant to rule 10.1, 10.2 or 10.3 as the case may be, within the period of 20 days commencing on the day after the day on which the relevant event occurs, failing which exercise the Options shall lapse automatically, PROVIDED THAT the Option may not be exercised later than the date falling six months after the occurrence of the relevant event within rule 10.1 or 10.3, as the case may be, or the expiry of the time period set out in rule 10.2, whichever is the first to occur.

**11.** **OPTION ROLLOVER** 

11.1 If any company (the  ***acquiring company***):

(a) obtains Control of the Company as a result of making:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) a general offer to acquire the whole of the issued ordinary share capital of the Company which is made on a condition such that if
it is satisfied the acquiring company will have Control of the Company; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) a general offer to acquire all the Shares,

and for the purposes of this rule 11.1(a), it does not matter if the general offer is made to different shareholders by different means; or

(b) obtains Control of the Company in pursuance of a compromise or arrangement sanctioned by the Court under
section 899 of the Companies Act 2006; or

(c) becomes bound or entitled to acquire shares in the Company under sections 979 to 982 of that Act,

each Option Holder may at any time within:

(x) in the case of 11.1(a), the period of 6 months beginning with the time when the acquiring company obtains
control and any condition subject to which the offer is made is met;

(y) in the case of 11.1(b), the period of 6 months beginning with the time when the court sanctions the compromise
or arrangement; and

(z) in the case of 11.1(c), the period during which the acquiring company remains bound or entitled as mentioned
in that provision,

by agreement with the acquiring company release any Option which has not lapsed (***the old option***) in consideration of the grant to them of an option (***the new option***) which (for the purposes of that paragraph) is equivalent to the old option but relates to shares in a different company (whether the acquiring company itself or another company falling within paragraph 18(b) or (c) of Schedule 3) (***the new grantor***).

11.2 The new option shall not be regarded for the purposes of rule 11.1 as equivalent to the old option unless the conditions set out in paragraph 39(4) of Schedule 3 are satisfied and, in relation to the new option, the provisions of the Scheme shall be construed as if:

(a) the new option were an option granted under the Scheme at the same time as the old option;

(b) references to the Company in rules 9, 10, 11, 12, 13, 14, 15, 16 and 18 were references to the new
grantor provided that references to Participating Company shall continue to be construed as if references to the Company within this definition
were to AstraZeneca Plc;

(c) references to the Board in rules 9, 12, and 18 were references to the board of directors of the new
grantor;

(d) references to Shares were references to shares in the new grantor;

(e) the Savings Contract made in connection with the old option had been made in connection with the new option;
and

(f) the Bonus Date in relation to the new option was the same as that in relation to the old option.

**12.** **ADJUSTMENT OF OPTIONS** 

In the event of any Capital Reorganisation, the Exercise Price and the number and description of Shares comprised in an Option may be adjusted in such manner as the Board may determine, provided always that:

(a) no adjustment may be made to an Option which would result in the requirements of paragraphs 1 to 27 (inclusive)
and paragraphs 29 to 49 (inclusive) of Schedule 3 not being met in relation to the Option;

(b) any adjustment made pursuant to this rule must secure that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the total market value of the Shares which may be acquired by the exercise of the Option is immediately
after such adjustment or adjustments substantially the same as what it was immediately before the adjustment or adjustments; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the total price at which those Shares may be acquired is immediately after the adjustment or adjustments
substantially the same as what it was immediately before the adjustment or adjustments;

(c) except as provided in this subparagraph (c) no adjustment may have the effect of reducing the Exercise
Price to less than the nominal value of a Share. Where an Option subsists over both issued or unissued Shares any such adjustment may
only be made if the reduction of the Exercise Price of Options over both issued and unissued Shares can be made to the same extent. Any
adjustment to the Exercise Price of Options over unissued Shares shall only be made if and to the extent that the Board shall be authorised
to capitalise from the reserves of the Company a sum equal to the amount by which the nominal value of the Shares in respect of which
the Option is exercisable exceeds the adjusted Exercise Price. The Board may apply such sum in paying up such amount on such Shares and
so that on exercise of any Option in respect of which such reduction shall have been made the Board shall capitalise such sum (if any)
and apply the same in paying up such amount as aforesaid; and

(d) in respect of an Option under which Shares are to be transferred, prior notification shall be given to
the person holding the Shares to which the Option relates and no adjustment shall take effect without the prior approval of such person
(such approval not to be unreasonably withheld).

For the purpose of this rule 12, "market value" shall have the same meaning as it has for the purposes of Part 8 of the Taxation of Chargeable Gains Act 1992 and if the Shares in question are subject to a Restriction, the market value of such Shares is to be determined as if they were not subject to such Restriction.

**13.** **ALLOTMENT OR TRANSFER OF SHARES ON EXERCISE OF OPTIONS** 

13.1 All allotments, issues and transfers of Shares will be subject to any necessary consents under any relevant enactments or regulations for the time being in force in the United Kingdom or elsewhere. The Option Holder is responsible for complying with any requirements they need to fulfil in order to obtain or avoid the necessity for any such consent.

13.2 Subject to any necessary consents under Rule 13.1, to payment being made for the Shares and to compliance by the Option Holder with the terms of the Scheme, not later than 30 days after receipt of any notice of exercise in accordance with rule 9.2, the Company shall either allot and issue or procure the transfer by the Trustee of Shares (including treasury shares held by the Company in accordance with section 724 to section 732 of the Companies Act 2006) to the Option Holder (or to their nominee). The Company or the Trustee shall (unless the Shares are to be issued in uncertificated form) as soon as practicable deliver to the Option Holder (or such nominee) a definitive share certificate or other evidence of title in respect of such Shares. Where the Shares are issued or transferred to a nominee of the Option Holder, the Option Holder shall remain the beneficial owner of the Shares.

**14.** **RIGHTS ATTACHING TO SHARES ALLOTTED OR TRANSFERRED PURSUANT TO OPTIONS** 

14.1 All Shares issued to satisfy the exercise of an Option shall rank equally in all respects with the Shares in issue at the date of allotment. They will not rank for any rights attaching to the Shares by reference to a record date preceding the date of allotment. Where Shares are transferred to an Option Holder, including a transfer out of treasury, the Option Holder will be entitled to all rights attaching to the Shares by reference to a record date on or after the transfer date. The Option Holder will not be entitled to rights before that date.

14.2 Any Shares acquired on the exercise of Options shall be subject to the articles of association of the Company from time to time in force.

**15.** **AVAILABILITY OF SHARES** 

15.1 The Company shall at all times keep available for issue sufficient authorised but unissued Shares to permit the exercise of all unexercised Options under which Shares may be allotted or shall otherwise procure that Shares are available for transfer in satisfaction of the exercise of Options.

15.2 If and so long as the ordinary shares are admitted to listing and to trading on the New York Stock Exchange, the Company will, at its expense, make an application to the New York Stock Exchange (and any other bodies as required) for ordinary shares allotted on the exercise of any Option to be admitted to such listing and trading. If and so long as the DIs are admitted to listing by the Financial Conduct Authority and admitted to trading on the London Stock Exchange, the Company will, at its expense, make an application to the Financial Conduct Authority and the London Stock Exchange for DIs allotted on the exercise of any Option to be admitted to such listing and trading respectively.

**16.** **ADMINISTRATION AND AMENDMENT** 

The decision of the Board shall be final and binding in all matters relating to the Scheme and it may at any time discontinue the grant of further Options or amend any of the provisions of the Scheme in any way it thinks fit PROVIDED THAT:

(a) if the Scheme is intended to continue to meet the requirements of Schedule 3, no amendment may be made
which would cause the requirements of Parts 2 to 7 inclusive of Schedule 3 to cease to be met in relation to the Scheme;

(b) except as herein provided, the Board shall not make any amendment that would materially prejudice the
interests of existing Option Holders except with the prior consent or sanction of Option Holders who, if they exercised their Options
in full, would thereby become entitled to not less than three-quarters of all the Shares which would fall to be allotted or transferred
upon exercise in full of all outstanding Options;

(c) no amendment to the advantage of Eligible Employees or Option Holders may be made:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) to the definition of Eligible Employee in rule 1.1;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the limitations on the number of Shares subject to the Scheme;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) the maximum entitlement for any Eligible Employee under the Scheme;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) the basis for determining an Eligible Employee's entitlement to Shares under the Scheme;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) the terms of Shares to be provided under the Scheme; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) the adjustments to Options, under rule 12, in the event of a Capital Reorganisation,

without the prior approval of the Company in general meeting except in the case of minor amendments to benefit the administration of the Scheme, to take account of a change in legislation or to obtain or maintain favourable tax, exchange control or regulatory treatment for Eligible Employees and Option Holders or any member of the Group; and

(d) without prejudice to any provision of the Scheme which provides for the lapse of an Option, the Board
may not cancel an Option unless the Option Holder agrees in writing to such cancellation.

**17.** **THIRD PARTY RIGHTS** 

17.1 Nothing in this Scheme confers any benefit, right or expectation on a person who is not an Option Holder. No such third party has any rights under the Contracts (Rights of Third Parties) Act 1999 or any equivalent local legislation to enforce any term of the Scheme. This does not affect any other right or remedy of a third party which may exist.

**18.** **DATA PROTECTION** 

18.1 Any personal data relating to an Eligible Employee and/or an Option Holder that is used in connection with the Scheme shall be processed in accordance with the Employee Data Privacy Notice as from time to time amended. A copy of the current Employee Data Privacy Notice will be available through the Company's intranet and/or HR system.

18.2 By participating in the Scheme, any Option Holder (who is resident outside the United Kingdom and the European Union) consents (which may be withdrawn at any time) to the holding and processing of personal information provided by the Option Holder to any member of the Group, the Trustee or third party service provider, for all purposes relating to the operation of the Scheme. These include, but are not limited to:

(a) administering and maintaining Option Holder records;

(b) providing information to members of the Group, Trustee registrars, brokers or third party administrators
of the Scheme;

(c) providing information to future purchasers or merger partners of the Company, the Option Holder's
employing company, or the business in which the Option Holder works;

(d) transferring information about the Option Holder to a country or territory that may not provide the same
statutory protection for the information as the Option Holder's home country.

18.3 The Option Holder is entitled, on payment of a fee (where permissible under applicable data protection laws and regulations), to a copy of the personal information held about them. If anything is inaccurate the Option Holder has the right to have it corrected.

19. **GENERAL** 

19.1 Any Participating Company may provide money to the Trustee or any other person to enable them to acquire Shares to be held for the purposes of the Scheme, or enter into any guarantee or indemnity for those purposes, to the extent permitted by section 682 of the Companies Act 2006.

19.2 The rights and obligations of an Option Holder under the terms and conditions of their office or employment shall not be affected by their participation in the Scheme or any right they may have to participate in the Scheme. An individual who participates in the Scheme waives all and any rights to compensation or damages in consequence of the termination of their office or employment with any company for any reason whatsoever (whether lawfully or unlawfully) insofar as those rights arise, or may arise, from their ceasing to have rights under or be entitled to exercise any Option under the Scheme as a result of such termination or from the loss or diminution in value of such rights or entitlements. If necessary, the Option Holder's terms of employment shall be varied accordingly.

19.3 The existence of any Option shall not affect in any way the right or power of the Company or its shareholders to make or authorise any or all adjustments, recapitalisations, reorganisations or other changes in the Company's capital structure, or any merger or consolidation of the Company, or any issue of shares, bonds, debentures, preferred or prior preference stocks ahead of or convertible into, or otherwise affecting the Shares or the rights thereof, or the dissolution or liquidation of the Company or any sale or transfer of all or any part of its assets or business, or any other corporate act or proceeding, whether of a similar character or otherwise.

19.4 Any information or notice to a person who is or will be eligible to be an Option Holder under or in connection with the Scheme may be posted, or sent by electronic means, in such manner to address as the Company considers appropriate, including publication on any intranet. Any information or notice to the Company or other duly appointed agent under or in connection with the Scheme may be sent by post or transmitted to it at its registered office or such other place, and by such other means, as the Board or duly appointed agent may decide and notify Option Holders.

19.5 The Company is not required to send to Option Holders copies of any documents or notices normally sent to the holders of its Shares.

19.6 The Company, or where the Board so directs any Subsidiary, shall pay the appropriate stamp duty on behalf of the Option Holders in respect of any transfer of Shares on the exercise of the Options.

19.7 The Company will pay the costs of introducing and administering the Scheme. The Company may ask an Option Holder's employer to bear the costs in respect of an Option granted to that Option Holder.

19.8 Benefits under this Scheme shall not be pensionable.

19.9 These rules shall be governed by, and construed in accordance with, the laws of England.

## Exhibit 4.8

**Exhibit 4.8**

**<u>DATED 24 NOVEMBER 2000</u>**

**ASTRAZENECA PLC**

**- and -**

**ASTRAZENECA EMPLOYEE SHARE TRUST LIMITED**

**TRUST DEED AND RULES**

**of**

**THE ASTRAZENECA ALL-EMPLOYEE**

**SHARE PLAN**

**Approved by the Inland Revenue under Reference: A1106/SY**

**Adopted by the Company on 8 November 2000 and amended on 11 December 2025**

**CONTENTS**

---

| | | |
|:---|:---|:---|
| **<u>THE TRUST DEED</u>** | **<u>THE TRUST DEED</u>** | **<u>Page</u>** |
| 1. | Definitions and Interpretation | 1 |
| 2. | Trusts of the Scheme | 1 |
| 3. | Notices to Participants | 3 |
| 4. | Investment | 3 |
| 5. | Borrowing | 4 |
| 6. | Receipt of Money or Money's worth with respect to Plan Shares | 4 |
| 7. | Application of the Plan to Group Companies | 4 |
| 8. | Retention of Shares subject to Holding Period | 5 |
| 9. | Voting Rights and Directions | 5 |
| 10. | Trustee's Powers of Delegation | 6 |
| 11. | Administration | 6 |
| 12. | Trustee's Indemnities and Charges | 8 |
| 13. | Appointment, Removal and Retirement of Trustee | 9 |
| 14. | Residence of the Trust | 10 |
| 15. | Amendments to the Plan | 10 |
| 16. | Termination of the Plan | 11 |
| 17. | Governing Law | 12 |
| 18. | Construction of this Deed | 12 |
| **<u>THE RULES OF THE ASTRAZENECA ALL-EMPLOYEE SHARE PLAN</u>** | **<u>THE RULES OF THE ASTRAZENECA ALL-EMPLOYEE SHARE PLAN</u>** |  |
| **<u>SCHEDULE</u>** | **<u>SCHEDULE</u>** | **<u>SCHEDULE</u>** |
| **<u>PART ONE</u>** | **<u>PART ONE</u>** | **<u>PART ONE</u>** |
| **Definitions and Interpretation** | **Definitions and Interpretation** | 13 |
| **<u>PART TWO</u>** | **<u>PART TWO</u>** |  |
| **Provisions affecting Plan Shares** | **Provisions affecting Plan Shares** | 21 |
| 1. | Operation of the Plan/Participation on the same terms | 21 |
| 2. | Participation Contract | 21 |
| 3. | Ineligibility due to participation in other share schemes | 22 |
| 4. | No Material Interest in a close company | 22 |
| 5. | Contributions to Trustee | 22 |
| 6. | Acquisition of Shares for the Plan/Limit on number of Shares which can be issued | 23 |
| 7. | Appropriation | 23 |
| 8. | Rights Issues | 24 |
| 9. | Capitalisation Issues | 25 |
| 10. | Company Reconstruction | 25 |
| 11. | Events during Holding Period | 26 |
| 12. | Shares in lieu of cash dividends | 27 |
| 13. | Fractional Entitlements | 28 |
| 14. | Transfer of Plan Shares | 28 |

---

---

| | | |
|:---|:---|:---|
| 15. | Stamp Duty | 28.0 |
| 16. | Notices | 29.0 |
| 17. | Disputes | 29.0 |
| 18. | Terms of Employment | 29.0 |
| 19. | Termination of the Plan | 30.0 |
| **<u>PART THREE</u>** | **<u>PART THREE</u>** |  |
| **Free Shares** | **Free Shares** | 32.0 |
| 1. | Invitation to Participate | 32.0 |
| 2. | Maximum value of Free Shares Appropriated | 32.0 |
| 3. | Performance Measures and Targets | 32.0 |
| 4. | Basis of Appropriation | 34.0 |
| **<u>PART FOUR</u>** | **<u>PART FOUR</u>** |  |
| **Partnership Shares and Matching Shares** | **Partnership Shares and Matching Shares** | 35.0 |
| 1. | Invitations | 35.0 |
| 2. | Partnership Share Money | 36.0 |
| 3. | No Accumulation Period | 36.0 |
| 4. | Accumulation Period | 37.0 |
| 5. | Stopping and re-starting deductions | 38.0 |
| 6. | Withdrawal of Partnership Shares | 39.0 |
| 7. | Number of Partnership Shares that can be acquired | 39.0 |
| 8. | Matching Shares | 40.0 |
| **<u>PART FIVE</u>** | **<u>PART FIVE</u>** |  |
| **Deed of Adherence** | **Deed of Adherence** | 41.0 |

---

**THIS DEED** is made the 24<sup>th</sup> day of November 2000

**BETWEEN:-**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) **ASTRAZENECA PLC** (registered number
 2723534) whose registered office is at 1 Francis Crick Avenue, Cambridge Biomedical Campus,
 Cambridge, United Kingdom, CB2 0AA ("the Company"); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) **ASTRAZENECA EMPLOYEE SHARE TRUST LIMITED** (registered number 2938700) whose registered office is at 1 Francis Crick Avenue, Cambridge
 Biomedical Campus, Cambridge, United Kingdom, CB2 0AA ("the Trustee").

**WHEREAS:-**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) The Company wishes to establish an employee
 share plan to be known as the AstraZeneca All-Employee Share Plan, approved in accordance
 with the provisions of Schedule 8 to the Finance Act 2000 and constituting an Employees'
 Share Scheme.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) The Plan was established by a of the Company
 passed on 8 November 2000.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(C) The Trustee has agreed to be the original
 trustee of the Plan.

**NOW THIS DEED WITNESSES** as follows:-

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.  **<u>DEFINITIONS AND INTERPRETATION</u>** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.1 **Definitions:** The words and expressions
 used in this Deed which have capital letters have the meanings set out in Part One of
 the Schedule.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.2 **Interpretation:** The provisions
 of Part One of the Schedule shall apply equally to this Deed.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.  **<u>TRUSTS OF THE SCHEME</u>** 

2.1 **Payments by Participating Companies:** The Company will pay to the Trustee the amounts necessary to enable the Trustee to acquire,
 in accordance with the Plan, Shares for and/or to be Appropriated to Qualifying Employees,
 together with any other amounts required to cover any liabilities incurred by the Trustee
 under the Plan. The Company can require any Participating Company to reimburse the Company
 for any amounts it bears under this Clause 2.1 directly or indirectly in respect of such
 Participating Company's officers or employees.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.2 **Application of Payments:** Unless
 otherwise stated, the Trustee will apply all monies received by it in accordance with the
 Plan and hold any Shares acquired and all other trust property deriving from them on the
 trusts declared in this Deed. In the case of any monies received for the acquisition of Free
 Shares or Matching Shares, the Trustee will acquire and Appropriate these Shares in accordance
 with the Plan. In the case of any monies received for the acquisition of Partnership Shares,
 the Trustee will acquire these Shares in accordance with the Plan.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.3 **Retention or sale of surplus Shares:** If it is not possible to Appropriate all the Shares purchased for Appropriation as Free
 Shares or Matching Shares without fractional entitlements arising or if, for any other reason,
 the Trustee holds Shares which were acquired to be Appropriated, but which are not Appropriated,
 the Trustee may retain so many of those Shares as the Company shall direct. Subject to that
 direction, the Trustee shall sell any Shares not Appropriated and apply the proceeds to meet
 any expenses of the sale and pay the balance (if any) to the Company.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.4 **Rights attaching to unappropriated Shares:** If the Trustee becomes entitled (in respect of any Shares not held on behalf
 of a Participant) to any rights to be allotted, or to subscribe for, further securities (other
 than an issue of capitalisation shares of the same class as specific Shares which the Trustee
 is about to Appropriate, which capitalisation shares shall be retained by the Trustee as
 Shares to be Appropriated among the Participants on the relevant Appropriation Day), the
 Trustee may:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.4.1 take up those rights or sell them for
 the best consideration in money reasonably obtainable at the time;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.4.2 sell sufficient of them nil paid to
 enable the Trustee to subscribe in full for the balance of any unsold rights; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.4.3 or allow those rights to lapse.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.5 **Trusts of unappropriated Shares:** Subject
 to Clause 2.3, the Trustee shall hold any unappropriated Shares or unutilised cash balances
 and any income arising from them UPON TRUST to purchase more Shares for the Plan and/or for
 the expenses of administering the Plan. The Trustee shall notify the Company from time to
 time of the amounts and/or number of Shares so held by it and its/their application.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.6 **Use of Shares acquired under a qualifying transfer:** Any Shares acquired by the Trustee by a transfer from an employee share ownership
 trust which is a qualifying transfer within

section 69(3AA) of the Finance Act 1989 must only be Appropriated as Free Shares or Matching Shares and in priority to other available Shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.  **<u>NOTICES TO PARTICIPANTS</u>** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.1 **Notice of Appropriation of Free Shares or Matching Shares:** As soon as practicable after the Trustee has Appropriated Free Shares
 or Matching Shares, it shall notify each Qualifying Employee of the number and description
 of the Shares Appropriated to him, the Initial Market Value of those Shares and the Holding
 Period applicable to them.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2 **Notice of acquisition of Partnership Shares:** As soon as practicable after the Trustee has acquired any Partnership Shares
 on behalf of a Qualifying Employee, it shall notify the Qualifying Employee of the number
 and description of the Shares acquired, the amount of Partnership Share Money applied in
 acquiring them and their Market Value on the Acquisition Date.

3.3 **Notice of Participant's tax liability:** Where a Participant becomes liable to income tax under Case V of Schedule D, Schedule
 E or Schedule F of the Taxes Act due to his participation in the Plan, the Trustee shall
 notify the Participant accordingly and inform him of any facts relevant to determining the
 amount of that liability. Where a cash dividend is paid in respect of Plan Shares which are
 shares in a company not resident in the United Kingdom, held on behalf of a Participant,
 the Trustee shall notify the Participant of any foreign tax deducted from the dividend before
 it was paid.

3.4 **Termination of the Plan:** On the termination
 of the Plan for whatever reason, the Trustee shall sell all unappropriated Shares and account
 for and pay to the Company any monies held by it.

4.  **<u>INVESTMENT</u>** 

4.1 **Trustee's power of investment:** The
 Trustee may invest any monies from time to time held by it and not immediately required as
 if it were the absolute beneficial owner of those monies.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.2 **No duty to invest:** The Trustee
 shall be under no duty to invest property held on trust under this Deed.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.  **<u>BORROWING</u>** 

Subject to the Articles of Association of the Trustee and the obtaining of any necessary approvals from any Participating Company, the Trustee may borrow money for the purposes of the Plan on such terms as it thinks fit.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.  **<u>RECEIPT OF MONEY OR MONEY'S WORTH WITH RESPECT TO PLAN SHARES</u>** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.1 **Obligation to pay over:** Subject
 to Clause 6.2, the Trustee shall, as soon as practicable following its receipt of any money
 or money's worth in respect of any Plan Shares, arrange for that money or money's
 worth to be paid to Participants in accordance with their respective entitlements.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.2 **Exceptions from obligation:** Clause
 6.1 shall:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.2.1 not apply to money's worth consisting
 of New Shares; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.2.2 be subject to Clause 11 and the Trustee's
 PAYE obligations or its obligations in respect of PAYE under Part X of Schedule 8.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.  **<u>APPLICATION OF THE PLAN TO GROUP COMPANIES</u>** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.1 **Extension of the Plan to Controlled Companies and/or Jointly Owned Companies:** The Plan may, with the consent of the Company,
 be extended to any Controlled Company or any Jointly Owned Company by the execution of a
 Deed of Adherence under which that company agrees to be bound by this Deed and the Plan.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.2 **Disapplication of the Plan to Participating Companies:** The Plan shall cease to apply to any company, other than the Company, at any
 time when:-

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.2.1 that company ceases to be a Controlled
 Company or a Jointly Owned Company; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.2.2 a notice is served by the Company upon
 the Trustee that the Plan shall not apply to that company,

provided that the rights of Participants employed by that company to Plan Shares Appropriated to them or acquired on their behalf while that company was a Participating Company shall not be affected.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.3 **Information from Participating Companies:** A Participating Company (or a former Participating Company, if appropriate) shall provide
 the Trustee with all information required from it for the operation of the Plan in such form
 as the Trustee shall reasonably require.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.  **<u>RETENTION OF SHARES SUBJECT TO HOLDING PERIOD</u>** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.1 **No disposal:** Subject to Clause
 8.2, the Trustee shall not dispose of any of a Participant's Plan Shares that are subject
 to a Holding Period other than at the written direction of the Participant given under the
 terms of the Participation Contract.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.2 **Permitted disposals during Holding Period:** Clause 8.1 shall:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.2.1 not apply if, at the time of the disposal,
 the Participant has ceased to be in Employment;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.2.2 be subject to a direction of that Participant
 given in accordance with Rule 11 of Part Two of the Schedule; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.2.3 be subject to Clause 11.3 of the Deed.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;9.  **<u>VOTING RIGHTS AND DIRECTIONS</u>** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;9.1 **Exercise of voting rights:** While
 Plan Shares are registered in the name of the Trustee, the Trustee may, at its discretion,
 in respect of any matter upon which, at a general meeting of the Company or at a meeting
 of the holders of any class of shares of the Company, it is entitled to exercise any voting
 rights attaching to those Plan Shares, invite the Participants on whose behalf those Plan
 Shares are held to direct it as to such exercise. The Trustee shall not be entitled in respect
 of Plan Shares held on behalf of Participants to vote on a show of hands unless all directions
 received from Participants who have given directions in respect of the particular resolution
 are identical. The Trustee shall not in any circumstances be under an obligation to call
 for a poll. If there is a poll, the Trustee shall vote only in accordance with the directions
 of Participants who have given directions and shall not vote in respect of Plan Shares where
 no directions have been received.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;9.2 **Voting rights attached to unappropriated Shares:** The Trustee may not vote in respect of Shares it holds which are not Plan Shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;9.3 **Giving of directions:** Subject to
 Clause 8 and Clause 11.3, the Trustee shall dispose of a Participant's Plan Shares
 and deal with any right conferred in respect of a Participant's Plan Shares to be allotted
 other shares, securities or rights of any description, only pursuant to a direction given
 by or on behalf of the Participant.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10.  **<u>TRUSTEE'S POWERS OF DELEGATION</u>** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10.1 **Trustee's power to employ agents:** The Trustee may, in the performance of its duties under the Plan, employ and pay any
 appropriate person, appoint any person as its agent to transact all or any business, and
 act on the advice or opinion of any professional or business person, and shall not be responsible
 for anything done or omitted or suffered in good faith in reliance on such advice or opinion.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10.2 **Delegation of Trustee's powers:** The Trustee may, to the extent permitted by law, delegate any of its powers and duties
 under the Plan to any person or company. The Trustee may not, however, delegate the duties
 and obligations imposed on the Trustee under the Schedule.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10.3 **Nominee shareholder:** The Trustee
 may allow any Shares to be registered in the name of an appointed nominee.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10.4 **Revocation of delegation:** The
 Trustee may at any time, and shall if directed to by the Company, revoke any delegation or
 arrangement made under this Clause and/or require any trust property held by another person
 to be returned to the Trustee.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10.5 **Execution of documents:** The Trustee
 may execute and may authorise any of its directors, officers or employees to execute on its
 behalf any documents in such manner as may be appropriate.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;11.  **<u>ADMINISTRATION</u>** 

11.1 **Meetings and regulations:** Subject to the terms of this Deed,
 the Trustee may convene meetings and make such regulations as it considers appropriate for the administration
 of the Plan.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;11.2 **Duty to keep accounts and records:** The Trustee shall maintain the accounts and records necessary for it to fulfill its own
 PAYE, Primary NICs and other obligations under the Plan and the PAYE and Primary NICs obligations
 of an Employer Company under the Plan.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;11.3 **Trustee's power to dispose of shares to meet its PAYE and/or Primary NICs obligations:** The Trustee shall, where either
 a PAYE obligation is imposed on it under Schedule 8 or a Primary NICs obligation arises,
 in either case as a result of a Participant's Plan Shares ceasing to be subject to
 the Plan (including due to the operation of this Clause), have the power to meet that PAYE
 or Primary NICs obligation by:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;11.3.1 disposing of any Participant's
 Plan Shares; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;11.3.2 a Participant paying to it a sum equal
 to the amount required to discharge that PAYE obligation.

The Trustee may dispose of a Participant's Plan Shares under Clause 11.3.1 by itself acquiring some or all of those Shares for the purposes of the Plan.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;11.4 **Trustee to pay Employer Company:** If as a result of a Participant's Plan Shares ceasing to be subject to the Plan a Participant
 is chargeable to income tax under Part X of Schedule 8 and an obligation to make a PAYE
 Deduction or a deduction in respect of Primary NICs arises in respect of that charge the
 Trustee shall, subject to Clauses 11.6 and 11.7, pay to the Employer Company a sum sufficient
 to enable it to discharge that obligation.

11.5 **Payment to Employer Company of Capital Receipts:** If the Trustee receives a sum of money which constitutes (or forms part of)
 a Capital Receipt in respect of which a Participant is chargeable to income tax in accordance
 with Part X of Schedule 8 or Primary NICs are chargeable when it is received by the
 Participant, the Trustee shall pay to the Employer Company out of that sum of money an amount
 equal to that on which income tax and Primary NICs are payable.

11.6 **Payment by Participant to Employer Company:** Clause 11.4 shall not apply if the relevant Participant is required to pay to his Employer
 Company a sum that is sufficient to enable it to discharge the obligation.

11.7 **No Employer Company:** In any case under
 Clause 11.4 or Clause 11.5, as appropriate, where:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;11.7.1 there is no Employer
 Company; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;11.7.2 the Inland Revenue have directed under
 paragraph 95(7) or 96(3), as appropriate, of Schedule 8 that it is impracticable for
 the Employer Company concerned to make a PAYE Deduction or a deduction in respect of Primary
 NICs.

Clause 11.4 or Clause 11.5 as appropriate, shall not apply and the Trustee shall make a PAYE Deduction or a deduction for Primary NICs in respect of an amount equal to that on which income tax or Primary NICs is payable as if the Participant were a former employee of the Trustee.

12.  **<u>TRUSTEE'S INDEMNITIES AND CHARGES</u>** 

12.1 **Trustee's indemnity:** The Participating
 Companies agree to keep the Trustee fully indemnified against any liability arising out of
 or in connection with the Plan. However, no Trustee will be indemnified or exonerated in
 respect of any fraud, negligence or willful default on it, its agents', or any of their
 officers' or employees' parts. The Trustee shall also have the benefit of any
 indemnities conferred upon trustees by law.

12.2 **Accounting for benefits received by the Trustee:** Neither the Trustee nor any of its officers or employees shall be liable to
 account to Participants for any benefit received under the Plan. No Trustee or officer or
 employee of the Trustee shall be liable to account to other Participants for any profit derived
 by him as a Participant.

12.3 **Trustee's remuneration:** Any
 person acting as a Trustee in the course of any profession or business carried on by him
 may charge and be paid such reasonable charges for acting as shall from time to time be agreed
 between him and the Company.

12.4 **Permitted dealings of Trustee:** Any
 Trustee (and any director or officer of a body corporate or a trust corporation acting as
 a Trustee) shall not, on its own account;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;12.4.1 be precluded from acquiring, holding
 or dealing with any debentures, debenture stock, shares or securities whatsoever of the Company,
 any Controlled Company or Jointly Owned Company or any other company in the shares of which
 the Company, any Controlled Company or any Jointly Owned Company may be interested;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;12.4.2 be precluded from entering into any
 contract or other transaction with the Company, any Controlled Company or any Jointly Owned
 Company or any other company, or from being interested in any such contract or transaction;
 or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;12.4.3 be in any way liable to account to
 the Company or any Controlled Company or any Jointly Owned Company or any Participant for
 any amount obtained by it from such acquisition, holding, dealing, contract or transaction,
 whether or not in connection with its duties under this Deed.

12.5 **Reliance on information provided:** The
 Trustee shall be entitled, in the absence of manifest error, to rely without further enquiry
 on:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;12.5.1 information supplied to it by any Participating
 Company for the purposes of the Plan; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;12.5.2 any direction, notice or document purporting
 to be given or executed by or with the authority of any Participating Company or by any Participant.

12.6 **Exclusion of liability:** The Trustee
 shall not be liable or responsible for any loss, liability or increased liability of a Participant
 arising out of the failure of the Participant to give a direction to the Trustee or to give
 a direction within a particular time or, if the Participant has directed the Trustee to use
 its discretion, arising out of the bona fide exercise by the Trustee of that discretion.

12.7 **Insurance:** The Trustee may insure
 against any loss caused by it or by any of its employees, officers, agents or delegates under
 the Plan. It may also insure itself and any of these persons against liability for breach
 of trust not involving willful wrongdoing or fraud of the Trustee or the person concerned.
 Except in the case of a paid Trustee, the insurance premiums may be paid from the Plan assets.

13.  **<u>APPOINTMENT, REMOVAL AND RETIREMENT OF TRUSTEE</u>** 

13.1 **The Trustee and the appointment and removal of the Trustee:** Unless the Trustee is a corporate Trustee, there must be two or more
 Trustees. The Company may at any time by writing:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.1.1 appoint a new (or additional) Trustee,
 including a corporate Trustee (to the exclusion of the Trustee's statutory power of
 appointment); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13.1.2 remove a Trustee from office (but not
 so as to leave in office less than two Trustees or a corporate Trustee), without assigning
 any reason for its removal which (in the absence of a date specified in the notice) shall
 take effect immediately.

13.2 **Appointment and removal on cessation of Company's existence:** The powers of appointment and removal shall be vested in the
 Trustee in the event that the Company ceases to exist otherwise than in consequence of a
 Company Reconstruction (as defined in Rule 10 of Part Two of the Schedule) or takeover,
 when the successor company (or, if more than one, such successor company as the Company shall
 nominate) shall have such powers.

13.3 **Retirement of Trustee:** A Trustee may
 retire by giving to the Company written notice which shall take effect at the end of three
 months (or another period agreed with the Company) from the date of that notice, provided
 that this will leave a Trustee in office. The retiring Trustee shall not be responsible for
 any costs caused by its retirement but shall do all things necessary to give proper effect
 to its retirement.

13.4 **Transfer of trust property:** Immediately
 on removal or retirement, a Trustee shall transfer all trust property held by it to the continuing
 Trustee and deliver all documents in its possession relating to the Plan as the Company may
 direct. If it does not do so, the continuing Trustee may do so on its behalf.

13.5 **Participants as Trustee:** A person
 shall not be disqualified from acting as a Trustee or an officer or employee of a Trustee
 of the Plan because he is or was an officer or employee of a Participating Company or is
 or was a Participant.

14.  **<u>RESIDENCE OF THE TRUST</u>** 

For so long as the Plan is to be approved under Schedule 8 any Trustee shall be resident in the United Kingdom for tax purposes.

15.  **<u>AMENDMENTS TO THE PLAN</u>** 

15.1 **Amendments to obtain/maintain Inland Revenue approval:** The Company may make any amendments to the Plan (including this Deed) that
 may be necessary to obtain and maintain approval of the Plan under Schedule 8 by the Inland
 Revenue.

15.2 **Company's power to amend:** Subject
 to the rest of this Clause 15, the Company may amend the Plan in any manner as it thinks
 fit (with any amendment being binding on the Trustee, all Participating Companies and Participants)
 but so that no purported amendment shall be effective:-

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;15.2.1 if the amendment is to a provision
 of the Plan that is necessary in order to meet the requirements of Schedule 8 if, and for
 so long as, the Plan is desired to be approved by the Inland Revenue, until that amendment
 is approved by the Inland Revenue; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;15.2.2 where it would cause the Plan to cease
 to be an Employees' Share Scheme; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;15.2.3 where it would materially adversely
 affect the rights of a Participant in respect of his Plan Shares unless it is made with his
 written consent or by a resolution passed as if all the Plan Shares held by the Trustee constituted
 a separate class of share capital and the provisions of the Articles of Association of the
 Company and the Companies Act 1985 relating to class meetings (with, in each case, the necessary
 amendments) applied to that class; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;15.2.4 where it would offend the rule against
 perpetuities.

15.3 **Shareholder approval**: To the extent
 that the Plan has received approval by ordinary resolution of the Company in general meeting,
 no amendment to the advantage of Participants or Eligible Employees can be made to the provisions
 in the Plan relating to:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;15.3.1 who can be a Participant or Eligible
 Employee; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;15.3.2 the number of Shares which the Trustee
 can subscribe for under the Plan; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;15.3.3 the basis for determining a Participant's
 entitlement to and the terms of the Shares and any adjustment in the event of a Variation,

without the approval by ordinary resolution of the Company in general meeting, except minor amendments to benefit the administration of the Plan, to take account of a change in legislation or to obtain or maintain favourable tax, exchange control or regulatory treatment for Participants or Eligible Employees or any Participating Company.

15.4 **Notice to Trustee:** Written notice
 of any amendment made in accordance with this Clause 15 shall be given to the Trustee.

15.5 **Additional parts:** The Company can
 adopt additional parts of the Plan applicable in any jurisdiction under which participation
 may be subject to additional and/or modified terms and conditions, having regard to any securities,
 exchange control or taxation laws, which apply to a Participant, any Participating Company
 or Associated Company. Any additional parts must conform to the basic principles of the Plan
 and must not enlarge to the benefit of Participants any limits in the Plan.

16.  **<u>TERMINATION OF THE PLAN</u>** 

16.1 **Decision not to operate:** The Company
 may resolve not to operate the Plan at any time. Any decision not to operate the Plan will
 not affect the subsisting rights of Participants.

16.2 **Decision to terminate the Plan:** The
 Company may resolve to terminate the Plan at any time. Where it does decide to do so, the
 Company will issue a Plan termination notice and provide a copy of this, without delay, to:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;16.2.1 the Inland Revenue;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;16.2.2 the Trustee; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;16.2.3 each individual who
 is either a Participant or has entered into a Partnership Share Agreement
 which was in force immediately before the notice was issued.

16.3 **Perpetuity period:** No acquisition
 of Shares may be made under the Plan later than seventy-six years after the date of this
 Deed or the earlier termination of the Plan by the Company. The perpetuity period applicable
 to this Deed shall be eighty years.

16.4 **Return of surplus assets:** Any surplus
 assets of the Trust on termination of the Plan shall be paid to the Company.

17.  **<u>GOVERNING LAW</u>** 

This Deed shall be governed by and construed in accordance with the law of England.

18.  **<u>CONSTRUCTION OF THIS DEED</u>** 

The Schedule shall be treated as part of this Deed.

IN WITNESS of which this Deed has been executed and delivered as a deed by the parties on the date which first appears in page 1.

**THE RULES OF**

**THE ASTRAZENECA ALL-EMPLOYEE SHARE PLAN**

**<u>SCHEDULE</u>**

**<u>PART ONE</u>**

**<u>DEFINITIONS AND INTERPRETATION</u>**

The words and expressions used in the Plan which have capital letters have the meanings set out below. Words and expressions not otherwise defined have the same meanings as they have in the Taxes Act. In this Plan:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the headings are for the sake of convenience
 and should be ignored when construing it;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) references to any statutory provisions
 are to those provisions as amended, extended or re-enacted from time to time and include
 any subordinate legislation made under them; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) unless the context requires otherwise,
 words in the singular include the plural and vice versa and words imputing either gender
 include both genders.

---

| | |
|:---|:---|
| **Accumulation Period** | in respect of Partnership Shares, the period during which a Qualifying Employee's Partnership Share Money is accumulated before it is used to acquire Partnership Shares or is repaid to that employee; |
| **Acquisition Date** | in respect of Partnership Shares and Matching Shares, the date determined under Rule 3.1 or Rule 4.3 of Part Four of the Schedule as appropriate; |
| **Announcement Date** | any date on which the Company makes an announcement to the New York Stock Exchange of its final or quarterly results for any financial year or other period for which the Company makes up its statutory accounts; |
| **Appropriation** | the vesting in a Qualifying Employee of a beneficial interest in Free Shares or Matching Shares (and references to Appropriate or Appropriated shall be read accordingly); |

---

---

| | |
|:---|:---|
| **Appropriation Day** | a day on which Free Shares or Matching Shares are Appropriated to a Qualifying Employee; |
| **Appropriation Year** | a Year of Assessment during which an Appropriation of Shares is or is intended to be made; |
| **Associated Company** | the meaning given in section 416 of the Taxes Act; |
| **Award Date** | the date on which an Appropriation is made and/or Partnership Shares are acquired on behalf of a Qualifying Employee; |
| **Board** | the board of directors of the Company or a duly authorised committee of the Board; |
| **Capital Receipt** | the meaning given in paragraph 79 of Schedule 8; |
| **Company** | AstraZeneca PLC (registered under no. 2723534) which for the purposes of the Plan may act through the Board or through a duly authorised employee or employees of a Participating Company; |
| **Connected Company** | means (i) the Company; (ii) a company which Controls or is Controlled by the Company or is Controlled by a company which also Controls the Company; and (iii) a company which is a Member of a Consortium owning the Company or which is owned in part by the Company as a Member of a Consortium; |
| **Continuous Employment** | the meaning given in the Employment Rights Act 1996; |
| **Control** | unless otherwise indicated, control within the meaning given in section 840 of the Taxes Act; |
| **Controlled Company** | any company (being a body corporate) which is a Subsidiary and under the Control of the Company; |
| **Dealing Day** | any day on which the New York Stock Exchange is open for business; |

---

---

| | |
|:---|:---|
| **The Deed** | this trust deed as amended from time to time; |
| **Deed of Adherence** | a deed substantially in the form set out in Part Five of the Schedule; |
| **DI** | a depositary interest issued through CREST representing a beneficial interest in an ordinary share in the capital of the Company; |
| **Eligible Employee** | an individual who on an Award Date: |

---

(i) (a) is in employment with
 the Company or a Participating Company; and

(b) is chargeable to tax in respect
 of that employment referred to in (a) above under Case I of Schedule E of the Taxes
 Act; and

(c) has such Qualifying Period
 (if any) as the Company may determine for that Award Date; or

---

| | |
|:---|:---|
| (ii) | is in employment with the Company or a Participating Company and nominated by the Company as an Eligible Employee (or is a member of a category of employees which is nominated by the Company as Eligible Employees) subject to having such Qualifying Period (if any) relevant for that Award Date, |
| unless the individual is ineligible to participate in the Plan by virtue of Rule 3 or Rule 4 of Part Two of the Schedule; | unless the individual is ineligible to participate in the Plan by virtue of Rule 3 or Rule 4 of Part Two of the Schedule; |

---

---

| | |
|:---|:---|
| **Employee Share**<br> **Ownership Plan** | an employee share ownership plan approved under Schedule 8 and established by a Connected Company; |

---

---

| | |
|:---|:---|
| **Employees' Share Scheme** | the meaning given in section 743 of the Companies Act 1985; |
| **Employer Company** | the company (if any) of which a Participant is an employee when, as appropriate, either (a) his Plan Shares cease to be subject to the Plan; or (b) the Trustee receives a sum of money which constitutes (or forms part of) a Capital Receipt in respect of his Plan Shares and to which the PAYE Regulations apply at that time; |
| **Employment** | employment with the Company or any of its Associated Companies; |
| **Free Shares** | Shares Appropriated to a Qualifying Employee under Part Three of the Schedule; |
| **Holding Period** | with respect to an Appropriation of Free Shares or Matching Shares, the period specified by the Company for that Appropriation during which those Shares will be held by the Trustee, which must be not less than three years nor more than five years from the Appropriation Day (or such other period(s) as may be permitted under paragraph 31(2) of Schedule 8 from time to time); |
| **Initial Market Value** | in relation to any Appropriation of Shares, their Market Value on the Appropriation Day, but the Market Value of any Shares subject to restrictions or risk of forfeiture (as that term is defined in paragraph 24 (3) of Schedule 8) is determined as if there were no restrictions or risk; |
| **Jointly Owned Company** | (i) any company of which 50 per cent of its issued share capital is owned by the Company and/or any Subsidiary of the Company and 50 per cent of its issued share capital is owned by another person; and (ii) any company under the Control of any such jointly owned company; |
| **London Stock Exchange** | The London Stock Exchange plc or any successor body carrying on the business of the London Stock Exchange; |

---

---

| | |
|:---|:---|
| **Market Value** | in relation to a Share on any day the average of its middle market quotation (as derived from the New York Stock Exchange Listings Directory, or where the context requires it, the Daily Official List of the London Stock Exchange) on the five Dealing Days immediately preceding that day; |
| **Matching Shares** | Shares Appropriated under Part Four of the Schedule; |
| **Material Interest** | the meaning given in paragraphs 17 to 19 of Schedule 8; |
| **Member of a Consortium** | the meaning given in paragraph 129(4) of Schedule 8; |
| **New Shares** | the meaning given in Rule 10.3; |
| **New York Stock Exchange** | The New York Stock Exchange or any successor body carrying on the business of the New York Stock Exchange; |
| **Notice Period** | the period of three months beginning with the date on which a copy of the termination notice is sent in accordance with Clause 16.2 of the Deed; |
| **Participant** | any person to whom an Appropriation has been made, or on whose behalf the Trustee holds Partnership Shares (or other securities); |
| **Participating Company** (i) | the Company; |
| (ii) | any Controlled Company which, with the approval of the Company, participates in the Plan; and |
| (iii) | any company which is a Jointly Owned Company and which, with the approval of the Company, participates in the Plan; |
| **Participation Contract** | a contract complying with Rule 2 of Part Two of the Schedule; |
| **Partnership Shares** | Shares acquired by the Trustee under Part Four of the Schedule on behalf of a Qualifying Employee; |

---

---

| | |
|:---|:---|
| **Partnership Share Agreement** | a contract complying with Rule 1 of Part Four of the Schedule; |
| **Partnership Share Money** | money deducted from a Qualifying Employee's Salary under a Partnership Share Agreement; |
| **PAYE Deduction** | a deduction required by regulations made under section 203 of the Taxes Act; |
| **PAYE Regulations** | the meaning given in section 203L(3) of the Taxes Act; |
| **Performance Unit** | any individual, team, divisional or corporate unit the Company may determine with respect to an Appropriation to be made under Rule 1 of Part Three of the Schedule; |
| **Permitted Cessation** | ceasing to be in Employment because of: |
| (i) | injury or disability; |

---

(ii) Redundancy;

(iii) a transfer
 to which the Transfer of Undertakings (Protection of Employment) Regulations 1981 apply;

(iv) a change of
 Control or other circumstances ending the Participating Company status of the Participating
 Company by which he is employed;

(v) circumstances
 determined by the Remuneration Committee of the Board of Directors of AstraZeneca to be retirement;
 or

(vi) death;

---

| | |
|:---|:---|
| **Plan** | the AstraZeneca All-Employee Share Plan established by the Deed and the Schedule; |
| **Plan Shares** | Free Shares, Matching Shares, Partnership Shares and/or, where appropriate, New Shares which are held by the Trustee on behalf of the Participants to whom they have been Appropriated or on whose behalf they have been acquired; |

---

---

| | |
|:---|:---|
| **Primary NICs** | Primary Class 1 national insurance contributions; |
| **Profit Sharing Scheme** | a profit sharing scheme approved under Schedule 9 to the Taxes Act and established by a Connected Company; |
| **Qualifying Corporate Bond** | the meaning given in section 117 of the Taxation of Chargeable Gains Act 1992; |
| **Qualifying Employee** | an Eligible Employee who has entered into a Participation Contract or Partnership Share Agreement, as appropriate; |
| **Qualifying Period** | the period (if any) of Continuous Employment determined by the Company with respect to any operation of the Plan, being a period starting not earlier than 18 months before the relevant Acquisition Date (except in the case of Partnership Shares and, if appropriate, Matching Shares to be acquired under a Partnership Share Agreement which provides for an Accumulation Period when the period must start no earlier than six months before the start of the Accumulation Period); |
| **Redundancy** | the meaning given in the Employment Rights Act 1996; |
| **Restricted Performance Measures** | Performance measures as defined in Rule 3.3 of Part Three of the Schedule; |
| **Salary** | such of the emoluments by reference to which an Eligible Employee is eligible to participate under the Plan as are liable to be paid under deduction of tax pursuant to section 203 of the Taxes Act (PAYE) after deducting amounts included by virtue of Chapter II of Part V of that Act (expenses and benefits-in-kind) or would be so liable apart from Schedule 8; |
| **Schedule** | the schedule to the Deed; |
| **Schedule 8** | Schedule 8 to the Finance Act 2000; |

---

---

| | |
|:---|:---|
| **Share** | a share (or where the context requires it, a DI) in the capital of the Company which satisfies the conditions specified in paragraphs 60 to 67 (inclusive) of Schedule 8 or, where the context permits in the event of a Company Reconstruction, such New Shares as forms part of any New Holding as those terms are defined in Rule 10 of Part Two of the Schedule; |
| **Subsidiary** | any company which in relation to the Company is a company as defined by section 736 of the Companies Act 1985 and which is under the Control of the Company; |
| **the Taxes Act** | the Income and Corporation Taxes Act 1988; |
| **Trustee** | the trustee referred to in the Deed or such other person or persons resident in the United Kingdom who is or are the trustee or trustees from time to time of the Plan; |
| **Unrestricted Performance Measures** | Performance measures as defined in Rule 3.4 of Part Three of the Schedule; |
| **Variation** | in relation to the equity share capital of the Company: |
| (i) | a capitalisation issue, an offer or invitation made by way of rights, a subdivision, a consolidation or reduction; or |
| (ii) | any other variation in respect of which the Inland Revenue may from time to time allow an adjustment of options under an employees' share option scheme; and |
| **Year of Assessment** | the meaning given in section 832 of the Taxes Act. |

---

**<u>PART TWO</u>**

**<u>PROVISIONS AFFECTING PLAN SHARES</u>**

1.  **<u>OPERATION OF THE PLAN/PARTICIPATION ON THE SAME TERMS</u>** 

1.1 **Company's discretion:** The Plan
 shall be operated at the discretion of the Company.

1.2 **Participation on the same terms:** Subject
 to Rules 3.3 and 3.4 of Part Three of the Schedule, every Eligible Employee must
 be invited to participate in the Plan in respect of any Appropriation of Shares or acquisition
 of Shares on their behalf on the same terms, and those who participate must do so on the
 same terms.

1.3 **Permitted factors:** The fact that participation
 in any operation of the Plan may be by reference to an Eligible Employee's remuneration,
 length of service or hours worked shall not infringe Rule 1.2 unless, where more than
 one of these three factors is used, paragraph 9(4) of Schedule 8 (which governs the
 extent to which Free Shares can be awarded by reference to more than one factor) is not complied
 with.

2.  **<u>PARTICIPATION CONTRACT</u>:** 

2.1 **Holding period:** A Participation Contract
 (which shall include a Partnership Share Agreement which provides for the Appropriation of
 Matching Shares) shall allow for the Holding Period applicable to the Free Shares (or Matching
 Shares) to which it relates to be specified and shall, subject to its provisions, bind the
 Eligible Employee in contract with the Company: -

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.1.1 to permit any Plan Shares which are
 subject to a Holding Period and Appropriated to him or acquired on his behalf to remain in
 the hands of the Trustee, as legal owner, throughout the Holding Period applicable to them;
 and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.1.2 not to assign, charge or otherwise dispose
 of his beneficial interest in any of those Plan Shares during their Holding Period.

2.2 **Forfeiture:** The Participation Contract
 shall, if appropriate, state in respect of the Appropriation of Free Shares (or in the case
 of a Partnership Share Agreement the Matching Shares) to which it relates the extent (if
 any) to which those Shares will be forfeited if, other than in the event of Permitted Cessation:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.2.1 the Participant ceases
 to be in Employment;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.2.2 the Participant withdraws
 the Shares from the Plan; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.2.3 in the case of Matching Shares only,
 if the Participant withdraws the Partnership Shares in respect of which those Matching Shares
 were Appropriated to him,

before the expiry of the period (not exceeding three years) from the Appropriation Day of the relevant Shares specified under the Participation Contract. If any Free Shares or Matching Shares are forfeited, a Participant shall cease to be beneficially entitled to those Shares.

3.  **<u>INELIGIBILITY DUE TO PARTICIPATION IN OTHER SHARE SCHEMES</u>** 

3.1 **Free Shares:** An individual shall not
 be eligible to receive an Appropriation of Free Shares in any Year of Assessment in which
 he has participated (or is at the same time to participate) in any Profit Sharing Scheme
 or any other Employee Share Ownership Plan.

3.2 **Partnership Shares or Matching Shares:** An individual shall not be eligible to participate in an invitation for Partnership Shares
 or Matching Shares in any Year of Assessment in which he has participated (or is at the same
 time to participate) in any other Employee Share Ownership Plan.

3.3 **Deemed Participation:** For the purposes
 of Rule 3.1 and Rule 3.2 an individual shall be treated as having participated
 in an Employee Share Ownership Plan if he would have received Free Shares under that plan
 but for his failure to meet a performance target.

4.  **<u>NO MATERIAL INTEREST IN A CLOSE COMPANY</u>** 

An individual shall not be eligible to participate in the Plan at any time when he has (or has within the preceding twelve months had) a Material Interest in the Company or any company which Controls the Company or is a Member of a Consortium which owns the Company. Paragraphs 15 and 17 to 22 of Schedule 8 shall apply to determine whether an individual is regarded as having or having had a Material Interest for the purposes of this Rule 4.

5.  **<u>CONTRIBUTIONS TO TRUSTEE</u>** 

Any contributions to be made to the Trustee to enable an acquisition of Shares to be made by the Trustee for Appropriation on any Appropriation Day shall be made within a sufficient time to allow for that Appropriation.

6.  **<u>ACQUISITION OF SHARES FOR THE PLAN/LIMIT ON NUMBER OF SHARES WHICH CAN BE ISSUED</u>** 

6.1 **Acquisition of Shares:** The Trustee,
 upon the direction of the Company, shall acquire Shares to be Appropriated as Free Shares
 or Matching Shares or which are to be acquired as Partnership Shares either:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.1.1 by subscription from the Company following
 the authority of the Company's shareholders in general meeting to do so; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.1.2 by purchase.

6.2 **The limit for Shares issued under the Plan:** The number of Shares which the Trustee may subscribe for under the Plan on any day, when
 aggregated with the number of Shares allocated under any other Employees' Share Scheme
 of the Company in the previous 10 years, cannot exceed 10 per cent. of the issued ordinary
 share capital of the Company from time to time.

6.3 **Meaning of allocation and exclusion from the limit:** The references in this Rule 6 to the "allocation" of Shares
 mean, in the case of any share option plan, the placing of unissued Shares under option and,
 in relation to any other Employees' Share Scheme, the issue and allotment of Shares.
 For the purpose of the limit in this Rule 6, Shares where the right to acquire such
 Shares was released, cancelled or lapsed without being exercised will be ignored.

6.4 **Adjustment to Shares to be taken into account:** Where Shares issued in connection with the Plan or any other Employees' Share Scheme
 of the Company are to be taken into account for the purposes of any of the limits in this
 Rule 6 and a Variation has taken place between the date of issue of those Shares and
 the date on which the limit is to be calculated, the number of Shares which will be taken
 into account for the purposes of the limit will be adjusted in such manner as the Company
 considers appropriate to take account of the Variation.

7.  **<u>APPROPRIATION</u>** 

7.1 **Timing of Appropriations:** An Appropriation
 of Free Shares can be made at any time, except in the case of the first Appropriation of
 Shares under the Plan, which cannot be made until the Plan has been approved by the Inland
 Revenue under Schedule 8.

7.2 **Rights attaching to Plan Shares:** Where
 the Trustee Appropriates or acquires Plan Shares a proportion of which rank for any dividend
 or other distribution or other rights attaching to Shares by reference to a record date preceding
 the relevant Appropriation Day or date of acquisition and a proportion of which do not, then
 the Shares to be Appropriated to each Qualifying Employee shall, as far as practicable, be
 in the same proportions.

8.  **<u>RIGHTS ISSUES</u>** 

8.1 **Instructions to Trustee:** Whenever any,
 securities or rights of any description are granted in respect of Plan Shares, each Participant
 shall be notified by the Trustee of the rights relating to his Plan Shares. Each Participant
 may direct the Trustee and the Trustee shall then be permitted to do one or more of the following:-

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.1.1 subject to the provision by the Participant
 of any necessary funds, to take up or sell all or any of the rights or allow them to lapse;
 and/or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.1.2 to sell rights nil paid to the extent
 necessary to enable the Trustee to subscribe in full for the balance of any unsold rights.

The Participant's instructions may be of particular or of general application and relate to Plan Shares Appropriated before and after the date of the rights issue.

8.2 **Period for giving instructions:** The
 Trustee shall act upon any such instruction received by it not less than 5 Dealing Days before
 the expiry of the period allowed for the exercise of any such rights. If any Participant
 has not by that time given instructions to the Trustee with regard to those rights and, if
 appropriate, provided any funds necessary for the purpose, the Trustee shall be deemed to
 have been instructed in accordance with Rule 8.1.2 above. The Trustee shall deal with
 any Capital Receipt received in consequence of the non-exercise or sale of any rights in
 accordance with Clause 11.5 of the Deed.

8.3 **New Shares:** Any shares, securities
 or rights taken up by the Trustee on behalf of any Participant under Rule 8.1.2 shall,
 subject to Rule 13 and provided that the right so to take up shares, securities or other
 rights was conferred in respect of all the Shares in the Company, form part of the Participant's
 Plan Shares and shall be deemed to have been Appropriated to or acquired on behalf of the
 Participant in the same way and at the same time as the Participant's Plan Shares in respect
 of which they are allotted.

8.4 **Trustee's indemnity:** Nothing
 in this Rule shall require the Trustee to act in any manner which would involve it in
 any liability unless indemnified to its satisfaction by the Participant against such liability.

9.  **<u>CAPITALISATION ISSUES</u>** 

Where any Shares are allotted by way of capitalisation to the Trustee in respect of any Participant's Plan Shares, those Shares shall, subject to Rule 13, form part of that Participant's Plan Shares and be deemed to have been Appropriated to, or acquired on behalf of, the Participant in the same way and at the same time as the Participant's Plan Shares in respect of which they are allotted.

10.  **<u>COMPANY RECONSTRUCTION</u>** 

10.1 **Company reconstruction:** This Rule applies
 if there occurs in relation to any of a Participant's Plan Shares (the "Original
 Shares") a transaction:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10.1.1 which results in a new holding (the
 "New Holding") being equated with the Original Shares for the purposes of capital
 gains tax; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10.1.2 that would have that result but for
 the fact that what would be the new holding would consist of or include a Qualifying Corporate
 Bond.

Such a transaction shall be referred to in this Plan as a Company Reconstruction.

10.2 **Excluded Shares:** If, as part of a
 Company Reconstruction, any:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10.2.1 redeemable shares or securities issued
 as mentioned in section 209(2)(a) of the Taxes Act;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10.2.2 share capital issued in circumstances
 such that section 210(1) of the Taxes Act applies; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10.2.3 share capital to which section 249
 of the Taxes Act applies,

is/are issued (and in respect of which a charge to income tax arises) those shares shall not form part of the New Holding for the purposes of this Rule.

10.3 **New Shares:** In this Rule "New
 Shares" means, subject to Rule 10.2, shares comprised in the New Holding which
 were issued in respect of, or otherwise represent, the Original Shares.

10.4 **Effect on Original Shares:** For the
 purposes of the Plan:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10.4.1 a Company Reconstruction shall be treated
 as not involving a disposal of the Original Shares;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10.4.2 the date on which any New Shares are
 to be treated as having been Appropriated to or acquired on behalf of a Participant shall
 be that on which his Original Shares were so Appropriated or acquired;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10.4.3 the conditions in Part VIII (types
 of shares that may be used) of Schedule 8 shall be treated as fulfilled with respect to any
 New Shares if they were (or were treated as) fulfilled with respect to the Original Shares;
 and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10.4.4 the provisions of Part X (income
 tax) and Part XI (capital gains tax) of Schedule 8 shall apply in relation to the New
 Shares as they would have applied to the Original Shares.

10.5 **References to Plan Shares:** Following
 a Company Reconstruction references to a Participant's Plan Shares shall be construed,
 subject to the above provisions, as being or, as the case may be, as including, references
 to any New Shares.

11.  **<u>EVENTS DURING HOLDING PERIOD</u>** 

11.1 **Takeover:** A Participant may during
 the Holding Period of any of his Plan Shares direct the Trustee to:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;11.1.1 accept an offer for those Plan Shares
 ("the Original Shares") if such acceptance will result in a new holding being
 equated with the Original Shares for the purposes of capital gains tax;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;11.1.2 accept an offer of a Qualifying Corporate
 Bond (whether alone or with other assets or cash or both) for those Plan Shares if the offer
 forms part of a general offer as mentioned in Rule 11.1.3 below; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;11.1.3 accept an offer of cash, with or without
 other assets, for those Plan Shares if the offer forms part of a general offer which is made
 to holders of shares of the same class as his shares in the Company and which is made in
 the first instance on a condition such that if it is satisfied the person making the offer
 will have control of the Company, within the meaning of section 416 of the Taxes Act; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;11.1.4 agree to a transaction affecting those
 Plan Shares or those of them which are of a particular class, if the transaction would be
 entered into pursuant to a compromise, arrangement or scheme applicable to or affecting:

(a) all the ordinary
 share capital of the Company or, as the case may be, all the shares of the class in
 question; or

(b) all the shares,
 or all the shares of the class in question, which are held by a class of shareholders
 identified otherwise than by reference to their employment or their participation in
 an employee share ownership plan approved under Schedule 8.

11.2 **Compulsory acquisition:** In the event
 of any Plan Shares being compulsorily acquired under sections 428 to 430F of the Companies
 Act 1985, the Participants concerned shall be entitled to receive notification of this from
 the Trustee as soon as practicable after the acquisition, and the provisions of Rules 13
 and 14 shall apply, with the necessary changes so far as relevant.

12.  **<u>SHARES IN LIEU OF CASH DIVIDENDS</u>** 

12.1 **Instructions to Trustee:** This Rule 12
 applies where:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;12.1.1 a Participant elects or has elected
 to join any dividend investment plan of the Company (the "Dip"); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;12.1.2 the holders of any class of shares
 of which some are Plan Shares are offered the right to elect to receive Shares, credited
 as fully paid in whole or in part, instead of a cash dividend (a "Scrip Offer"),
 and, under the Scrip Offer the Participant has elected to receive Shares.

As regards a Scrip Offer the Participant's election may be of particular or of general application and relate to Plan Shares Appropriated before and after the date of the relevant dividend. The Trustee shall not be obliged to notify Participants of their right to elect for Shares under a Scrip Offer and, in the absence of any election, the Participant shall be deemed to have elected for cash.

12.2 **Vesting of Shares:** Any Shares taken
 up by the Trustee on behalf of any Participant under the Dip or a Scrip Offer shall not form
 part of the Participant's Plan Shares to which they relate and shall belong to the Participant.
 The Trustee shall, subject to Clause 11 of the Deed and its PAYE obligations or its obligations
 in respect of PAYE under Part X of Schedule 8, take all reasonable steps to procure
 that the Participant (or his nominee) receives the Shares as soon as practicable.

12.3 **Cash dividends:** Any dividend of money
 or money's worth paid in respect of a Participant's Plan Shares shall be paid
 to the Participant by, or on behalf of, the Trustee in accordance with Clause 6 of the Deed.

13.  **<u>FRACTIONAL ENTITLEMENTS</u>** 

13.1 **Proportionate allocation:** Where the
 Trustee receives additional rights or securities in respect of Plan Shares under a capitalisation
 or rights issue or similar offer or invitation, the Trustee shall allocate those rights or
 securities amongst the Participants concerned on a proportionate basis. If that allocation
 gives rise to a fraction of a security or of a transferable unit of a security (in this Rule "unit"),
 the Trustee shall round the allocation down to the next whole unit and aggregate the fractions
 not allocated. The Trustee shall use its best endeavours to sell any rights or units which
 are not allocated and distribute the net proceeds of sale (after deducting from them any
 expenses of sale and any taxation which may be payable in respect of them) proportionately
 among the Participants whose allocation was rounded down, but so that any sum of less than
 £3 otherwise distributable to a particular Participant may be retained by the Trustee
 and used for the purposes of the Plan.

13.2 **Allocation by reference to time of Appropriation:** In any circumstances in which the Trustee receives New Shares which form part of a Participant's
 Plan Shares, the Trustee shall allocate the New Shares to the Participant by reference to
 the relative times of Appropriation or acquisition of his Plan Shares to which they relate.
 If that allocation gives rise to a fraction of a New Share, the Trustee shall, subject to
 the Taxes Act, round the allocation up or down to the next whole unit as it, in its discretion,
 thinks fit.

14.  **<u>TRANSFER OF PLAN SHARES</u>** 

Subject to Clause 11.3 of the Deed, the Trustee shall as soon as practicable after it is required to under the Plan, transfer the legal title to any Plan Shares it holds on behalf of that Participant into the name of the relevant Participant (or his nominee).

15.  **<u>STAMP DUTY</u>** 

Any stamp duty or other expenses involved in any transfer of Shares by the Trustee shall be payable: -

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;15.1 in the case of a transfer into the name
 of the Participant concerned (or his nominee), by the Trustee (and reimbursed by the Company);
 and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;15.2 in any other case, by the transferee
 concerned.

16.  **<u>NOTICES</u>** 

16.1 **Instructions to Trustee:** Any instruction
 given to the Trustee by or on behalf of a Participant or any person in whom the beneficial
 interest in his Plan Shares is for the time being vested under the Plan must be given in
 writing and, unless given electronically, signed by the relevant person.

16.2 **Notices:** Any notice which the Trustee
 is required or wants to give to any Eligible Employee, Qualifying Employee or Participant
 under the Plan shall be in writing and sufficiently given if (i) delivered to him personally
 or sent first class through the post pre-paid; or (ii) sent by electronic mail, in either
 case addressed to the Eligible Employee, Qualifying Employee or Participant at the address
 (being an electronic mail address where appropriate) last known to the Trustee (including
 any address supplied by the relevant Participating Company). If the notice is sent by post
 it shall be deemed to have been duly given on the day following the date the notice is posted
 or if sent by electronic mail on the day following the date of transmission. Any notice so
 sent to a person shall be deemed to have been duly delivered notwithstanding that he be then
 deceased (whether or not the Trustee has notice of his death) except where his personal representatives
 have established their title to the satisfaction of the Trustee and supplied to the Trustee
 an address (being an electronic mail address, if appropriate) to which documents are to be
 sent.

17.  **<u>DISPUTES</u>** 

The decision of the Company on any dispute or question affecting any Eligible Employee, Qualifying Employee or Participant under the Plan shall be final and conclusive.

18.  **<u>TERMS OF EMPLOYMENT</u>** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;18.1 **Rights of Participants and Eligible Employees:** Participation in the Plan is not pensionable. Nothing in the Plan nor in any
 instrument executed under it will confer upon any person any right to continue in Employment,
 nor will it affect the right of any Participating Company to terminate the Employment of
 any person without liability at any time with or without cause, nor will it impose upon any
 Participating Company or the Trustee or the Board or their respective agents and employees
 any liability whatsoever (whether in contract, tort, or otherwise howsoever) in connection
 with:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;18.1.1 the loss of a Participant's benefit
 or rights under the Plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;18.1.2 the failure or refusal of any person
 to exercise any discretion under the Plan; and/or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;18.1.3 a Participant ceasing to be a person
 who has the status or relationship of an employee or executive director with the Company
 or any other Participating Company or Associated Company for any reason as a result of the
 termination of his Employment.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;18.2 **Waiver of any rights:** Any person
 whose Employment ceases for any reason as a result of dismissal (lawfully or otherwise) shall
 not be entitled and shall be deemed irrevocably to have waived any entitlement by way of
 damages for dismissal or by way of compensation for loss of office or otherwise to any sum,
 damages, Shares or other benefits to compensate that person for the loss of any rights, benefits
 or expectations under the Plan or any instrument executed under it.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;18.3 **The Benefit of Rule 18.1 and Rule 18.2:** The benefit of Rule 18.1 and Rule 18.2 is given for the Company
 and/or the Trustee, as appropriate, for itself and as trustee and agent of the Company (if
 the benefit is given for the Trustee), and of all the Company's Subsidiaries or any
 of its Associated Companies and the Company and/or the Trustee, as appropriate, will hold
 the benefit of Rule 18.1 and Rule 18.2 on trust and as agent for each of them and
 the Company and/or the Trustee may, at their respective discretion, assign the benefit of
 this Rule 18.3 to any of them.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;18.4 **No obligations to make contributions:** Nothing in the Plan shall be construed as imposing on a Participating Company a contractual
 obligation as between that Participating Company and any Qualifying Employee or Participant
 to contribute or to continue to contribute to the Plan.

**19.** **TERMINATION OF THE PLAN** 

19.1 **The effect of terminating the Plan:** If the Company issues a Plan termination notice in accordance with Clause 16.2 of the Deed:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;19.1.1 no further Shares
 may be Appropriated under the Plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;19.1.2 the Trustee must, subject to Rule19.2,
 remove the Plan Shares from the Plan as soon as reasonably practical after:

(a) the end of the
 Notice Period; or

(b) if later, the
 first date on which the Plan Shares may be removed from the Plan without giving rise to a
 charge to income tax under part X of Schedule 8 on the Participant on whose behalf they
 are held; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;19.1.3 the Trustee must repay as soon as
 reasonably practicable any Partnership Share Money and on behalf of the Participant, together
 with any money held by the Trustee on behalf of the Participant.

19.2 **Participants consent to early release:** The Trustee may remove a Participant's Plan Shares from the Plan at a date earlier
 than that given by rule 19.1.2 provided that the Participant has given his consent after
 he has received a copy of the Plan termination notice. Any consent given by the Participant
 before he receives a copy of the Plan Termination notice shall be disregarded for the purposes
 of this Rule 19.2.

19.3 **How the Trustee can remove Plan Shares:** The Trustee may remove Plan Shares from the Plan by:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;19.3.1 transferring the Plan Shares to the
 Participant on behalf of whom they are held, or to another person at the Participant's
 direction; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;19.3.2 disposing of the Shares and accounting
 (or holding themselves ready to account) for the proceeds to the Participant or to another
 person at his direction.

**<u>PART THREE</u>**

**<u>FREE SHARES</u>**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.  **<u>INVITATION TO PARTICIPATE</u>** 

If the Company resolves that an Appropriation of Free Shares shall be made, it shall invite all Eligible Employees who are not at that time a party to a Participation Contract, to participate by issuing to them a Participation Contract. To consent to the Appropriation of Free Shares an Eligible Employee must return the Participation Contract duly completed by the date specified in it. If the Company does not receive a Participation Contract from an Eligible Employee by the specified date that Eligible Employee shall be deemed to have declined to participate in the Plan at that time. The Company shall specify the Holding Period for the Free Shares to be Appropriated on an Appropriation Day. The Holding Period of any Free Shares already Appropriated under the Plan cannot be increased.

2.  **<u>MAXIMUM VALUE OF FREE SHARES APPROPRIATED</u>** 

The maximum aggregate Initial Market Value of the Free Shares Appropriated to a Qualifying Employee in an Appropriation Year shall not exceed the maximum amount permitted by paragraph 24 of Schedule 8 from time to time (currently £3,000).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.  **<u>PERFORMANCE MEASURES AND TARGETS</u>** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.1 **Appropriation may be subject to performance measures**: An Appropriation of Free Shares may be made subject to performance measures
 and targets as provided for under this Rule 3.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2 **Requirements as to performance measures:** If any Appropriation of Free Shares under the Plan is to be made subject to performance measures
 they must be:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.1 provided for all persons who are Eligible
 Employees in respect of that Appropriation;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.2 based on business results or other objective
 criteria;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.3 fair and objective measures of the performance
 of the Performance Units to which they apply;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.4 set for Performance Units where no employee
 can be a member of more than one Performance Unit; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2.5 be either Restricted Performance Measures
 or Unrestricted Performance Measures.

3.3 **Restricted Performance Measures**: If
 the Company decides to Appropriate Free Shares by reference to Restricted Performance Measures,
 at least 20 per cent. of the Free Shares to be Appropriated must be Appropriated without
 reference to performance measures and shall be Appropriated on the same terms as required
 by Rule 1 of Part Two of the Schedule. The remaining Free Shares shall be Appropriated
 subject to performance measures but so that, in respect of that Appropriation, the highest
 Appropriation made to a Qualifying Employee by reference to performance shall be no more
 than four times the highest Appropriation to a Qualifying Employee without reference to performance.
 The Free Shares awarded by reference to performance need not be allocated on the same terms
 as required by Rule 1 of Part Two of the Schedule.

3.4 **Unrestricted Performance Measures:** If the Company decides to Appropriate Free Shares by reference to Unrestricted Performance
 Measures some or all of the Free Shares shall be Appropriated by reference to performance
 measures but so that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.4.1 Appropriations of Free Shares to Qualifying
 Employees who are members of the same Performance Unit shall be made on the same terms as
 required by Rule 1 of Part Two of the Schedule; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.4.2 Free Shares Appropriated for each Performance
 Unit shall be treated as separate Appropriations.

3.5 **Company's obligation to notify**:
 If an Appropriation of Free Shares under the Plan is to be made subject to performance measures
 and targets the Company must, as soon as reasonably practicable, notify each Eligible Employee
 participating:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.5.1 of the performance measures and targets
 which will be used to determine the number or value, as appropriate, of Free Shares Appropriated
 to him; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.5.2 in general terms of the performance
 measures and targets which will be used to determine the number or value, as appropriate,
 of Free Shares to be Appropriated to each Eligible Employee participating in that Appropriation.

3.6 **Confidential Information:** In fulfilling
 its obligation under Rule 3.5.2 above the Company shall not be obliged to disclose any
 information which it reasonably considers would prejudice commercial confidentiality.

4.  **<u>BASIS OF APPROPRIATION</u>** 

4.1 **Free Shares – no performance measures**:
 Free Shares to be Appropriated to Qualifying Employees pursuant to Rule 1 above shall
 be Appropriated on a basis determined by the Company but so that such basis complies with
 Rule 1 of Part Two of the Schedule.

4.2 **Free Shares – performance measures**:
 The Company shall determine in respect of any Appropriation of Free Shares to be made subject
 to performance measures (i) what the Performance Units are to be for that Appropriation;
 (ii) what performance measures and targets are to be used; and (iii) whether the
 performance measures are Restricted Performance Measures or Unrestricted Performance Measures.

**<u>PART FOUR</u>**

**<u>PARTNERSHIP SHARES AND MATCHING SHARES</u>**

1.  **<u>INVITIATIONS</u>** 

1.1. **Invitations to Eligible Employees:** If the Company decides to give Eligible Employees the opportunity to acquire Partnership
 Shares, each Eligible Employee will be sent an invitation to enter into a Partnership Share
 Agreement under which, if entered into:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.1.1 the Eligible Employee would authorise
 the Company to deduct part of his salary for the acquisition of Partnership Shares; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.1.2 the Company would agree to arrange for
 Partnership Shares to be acquired on behalf of the Eligible Employee in accordance with the
 Plan.

To participate in the opportunity to acquire Partnership Shares an Eligible Employee must return a Partnership Share Agreement duly completed by the date specified by the Company. If the Company does not receive a duly completed Partnership Share Agreement from an Eligible Employee by the specified date, that Eligible Employee shall be deemed to have declined to participate in the opportunity to acquire Partnership Shares at that time.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.2 **Maximum deductions from Salary:** The Partnership Share Agreement must stipulate the maximum amount of Partnership Share Money
 (or percentage of Salary) that may be deducted from an Eligible Employee's Salary and
 the intervals at which such deductions are to be made, but so that the maximum amount cannot
 exceed the amount permitted by paragraph 36 of Schedule 8 from time to time (currently £125
 in any month) and cannot, in any event, exceed ten per cent. of the Eligible Employee's
 Salary.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.3 **Percentage of Salary:** For the purposes
 of Rule 1.2 above, ten per cent. of Salary shall mean:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.3.1 if the Partnership Share Agreement does
 not provide for an Accumulation Period, ten per cent. of the Salary payment from which the
 deduction is made; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.3.2 if the Partnership Share Agreement provides
 for an Accumulation Period, ten per cent. of the Salary payments over the Accumulation Period.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.4 **Minimum deductions from Salary:** The Partnership Share Agreement in respect of any invitation shall also stipulate that the
 minimum monthly amount (irrespective of the interval for deductions) to be deducted from
 a Participant's Salary in pursuance of that Agreement must not be less than a minimum
 amount which must not be greater than £10.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.5 **Prescribed notice:** The Partnership
 Share Agreement must contain a notice in a prescribed form in compliance with paragraph 38
 of Schedule 8 (information as to the possible effect of deductions on an employee's
 entitlement to social security benefits, statutory sick pay and statutory maternity pay).

2.  **<u>PARTNERSHIP SHARE MONEY</u>** 

2.1 **Payment to Trustee:** Any Partnership
 Share Money shall be paid to the Trustee as soon as practicable following its deduction from
 a Qualifying Employee's Salary and shall be held by the Trustee on his behalf pending
 its application in accordance with Rule 3.1 or 4.3 of this Part Four, as appropriate,
 in an account (which may be interest bearing but does not have to be) with:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.1.1 an institution authorised
 under the Banking Act 1987;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.1.2 a building society;
 or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.1.3 a relevant European
 institution.

The Company shall determine and inform the Trustee of whether the account will be interest bearing.

If the Partnership Share Money held on behalf of a Qualifying Employee is held in an interest bearing account, the Trustee shall account for the interest to that Qualifying Employee.

2.2 **Repayment if approval of the Plan is withdrawn**:
 If the Inland Revenue give notice to the Company withdrawing approval of the Plan any Partnership
 Share Money held by the Trustee on behalf of a Participant must be repaid to that Participant
 as soon as practicable after notice of the withdrawal of approval is given to the Company.

3.  **<u>NO ACCUMULATION PERIOD</u>** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.1 **Acquisition of Shares:** Any Partnership
 Share Money deducted from a Participant's Salary under a Partnership Share Agreement with
 no Accumulation Period will be applied by the Trustee in acquiring Partnership Shares on
 a date (the "Acquisition Date") set by the Trustee which is within 30 days after
 the deduction is made. The number of Shares acquired on behalf of a Participant shall be
 determined by reference to the Market Value of the Shares on that Acquisition Date.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2 **Surplus Partnership Share Money:** Any surplus Partnership Share Money remaining after the acquisition of Partnership Shares
 by the Trustee on behalf of a Participant may, with the agreement of the Participant (which
 may be provided for in the Partnership Share Agreement), be carried forward and added to
 the amount of the next deduction of Salary. In any other case it must be paid over to the
 Participant (subject to deduction of income tax under PAYE and Primary NICs, as appropriate)
 as soon as practicable.

4.  **<u>ACCUMULATION PERIOD</u>** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.1 **Accumulation Period:** If the Board
 decides to offer an Accumulation Period in respect of an invitation to acquire Partnership
 Shares, the Partnership Share Agreement must specify:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.1.1 the length of the Accumulation Period
 (which cannot exceed twelve months or, if different, any period specified from time to time
 in paragraph 41 (1) of Schedule 8);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.1.2 the date of the start of the Accumulation
 Period (which may not be later than the date on which the first deduction of Salary is made
 under that Agreement); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.1.3 the date of the end of the Accumulation
 Period and whether the Accumulation Period will come to an end on the occurrence of (a) specified
 event(s).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.2 **Transaction resulting in a new holding:** If, during an Accumulation Period, a transaction occurs in relation to any Partnership
 Shares ("the original holding") to be acquired under a Partnership Share Agreement
 which results in a new holding of shares being equated with the original holding for the
 purposes of capital gains tax and the Participant so consents, the Partnership Share Agreement
 shall have effect after the time of that transaction as if it were an agreement for the purchase
 of shares comprised in the new holding.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.3 **Acquisition of Shares:** Subject
 to Rule 4.5, the Partnership Share Money deducted in respect of a Participant during
 an Accumulation Period must be applied by the Trustee in acquiring Partnership Shares on
 behalf of that Participant on a date (the "Acquisition Date") set by the Trustee
 which is within 30 days after the end of that Accumulation Period. The number of Shares acquired
 on behalf of a Participant will be determined by reference to the lower of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the Market Value of
 the Shares at the beginning of the Accumulation Period; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the Market Value of
 the Shares on their Acquisition Date.

4.4 **Surplus Partnership Share Money:** Any
 surplus Partnership Share Money remaining after the acquisition of Partnership Shares by
 the Trustee may, with the agreement of the Participant (which may be provided for in the
 Partnership Share Agreement), be carried forward to the next Accumulation Period. In any
 other case it must be paid over to the Participant (subject to deduction of income tax under
 PAYE and Primary NICs, as appropriate) as soon as practicable.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.5 **Repayment of Partnership Share Money:** In any case where Partnership Share Money has been deducted in an Accumulation Period and
 either:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.5.1 the Participant ceases to be in Employment
 during that Accumulation Period; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.5.2 the Accumulation Period comes to an
 end on the occurrence of an event specified in the Partnership Share Agreement,

the Partnership Share Money deducted in that Accumulation Period must be paid over to the Participant (subject to deduction of income tax under PAYE and Primary NICs, as appropriate) as soon as practicable.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.  **<u>STOPPING AND RE-STARTING DEDUCTIONS</u>** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.1 **Stopping deductions:** A Participant
 may at any time after entering into a Partnership Share Agreement give notice in writing
 to the Company to stop deductions from his Salary in pursuance of that Partnership Share
 Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.2 **Re-starting deductions:** A Participant
 who has stopped deductions from his Salary in pursuance of a Partnership Share Agreement
 may subsequently give notice in writing to the Company to re-start deductions from his Salary
 in pursuance of that Partnership Share Agreement. However:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.2.1 any deductions that have been missed
 may not be made up; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.2.2 where the deductions are made during
 an Accumulation Period, the Partnership Share Agreement may prevent a Participant from re-starting
 deductions more than once in that Accumulation Period.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.3 **Termination of Partnership Share Agreement:** A Participant may terminate his Partnership Share Agreement at any time by giving notice
 in writing to the Company. Where a Participant terminates his Partnership Share Agreement,
 no further deductions shall be made from his Salary and any Partnership Share Money held
 on his behalf shall be paid over to him (subject to deduction of income tax under PAYE and
 Primary NICs, as appropriate) as soon as practicable.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.4 **Effect of notice under Rules 5.1, 5.2 and 5.3**: Unless a later date is specified in any notice given under:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.4.1 Rules 5.1 and 5.3 above, the Company
 must give effect to such a notice within 30 days of receiving it; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.4.2 Rule 5.2 above, the Company must
 re-start deductions under the Partnership Share Agreement no later than the date of the first
 deduction due under the Partnership Share Agreement more than 30 days after receipt of the
 notice.

6.  **<u>WITHDRAWAL OF PARTNERSHIP SHARES</u>** 

A Participant may withdraw his Partnership Shares from the Plan at any time.

7.  **<u>NUMBER OF PARTNERSHIP SHARES THAT CAN BE ACQUIRED</u>** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.1 **Limit specified at time of invitation:** The Company may specify at the time of making an invitation under Rule 1 the maximum
 number of Partnership Shares that can be acquired on behalf of Eligible Employees in respect
 of that invitation. The Partnership Share Agreement shall contain an undertaking by the Company
 to notify each Qualifying Employee of any limit on the number of shares to be acquired:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.1.1 if there is no Accumulation Period,
 before the deduction of any Partnership Share Money under the Partnership Share Agreement;
 or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.1.2 if there is an Accumulation Period,
 before the beginning of the Accumulation Period under that Partnership Share Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.2 **Scaling down:** If the Company receives applications for Partnership Shares in excess of the maximum
 number of Partnership Shares specified in respect of that invitation under Rule 7.1 then
 the following steps shall be taken in sequence until the excess number is eliminated:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.2.1 the excess of the
 monthly deduction chosen by each Qualifying Employee over the amount stipulated under
 Rule 1.4 shall be reduced pro rata;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.2.2 all monthly deductions
 shall be reduced to the amount stipulated under Rule 1.4; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.2.3 Partnership Share
 Agreements shall be selected by lot, each based on a monthly deduction of the amount
 stipulated under Rule 1.4.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.3 **Modification/Withdrawal and Notification:** If Rule 7.2 applies each Partnership Share Agreement shall be deemed to have been modified
 or withdrawn in accordance with Rule 7.2 and each Qualifying Employee shall be notified
 of the change to his Partnership Share Agreement.

8.  **<u>MATCHING SHARES</u>** 

8.1 **Matching Shares – Acquisition and Forfeiture**: If the Company decides, in conjunction with an invitation to acquire Partnership
 Shares, to offer Matching Shares, each Eligible Employee shall be sent a Partnership Share
 Agreement. The Partnership Share Agreement will state the extent (if any) to which the Matching
 Shares appropriated to a Participant in respect of the associated Partnership Shares will
 be forfeited if the Participant:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.1.1 ceases to be in Employment (other than
 because of a Permitted Cessation); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.1.2 withdraws the Matching Shares from the
 Plan; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.1.3 withdraws the associated Partnership
 Shares from the Plan

in each case within such period stated in the Partnership Share Agreement (not to exceed three years) after the relevant Shares were Appropriated to him or acquired on his behalf, as appropriate.

8.2 **Terms of Matching Shares**: Matching
 Shares shall:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.2.1 be Shares of the same class and carrying
 the same rights as the Partnership Shares to which they relate;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.2.2 be Appropriated on the same day as the
 Partnership Shares to which they relate are acquired on behalf of the Participant; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.2.3 in respect of any Appropriation, be
 Appropriated to all Participants on exactly the same basis.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.3 **Ratio of Matching Shares**: The Partnership
 Share Agreement under which Matching Shares are offered must specify the ratio of Matching
 Shares to Partnership Shares for the time being offered by the Company and the circumstances
 and manner in which the ratios may be changed by the Company. The ratio must not exceed 2:1
 (or such other ratio permitted by paragraph 51 (2) of Schedule 8 from time to time).
 The Participant must be informed by the Company if the ratio offered by the Company changes
 before Partnership Shares are acquired on his behalf under the relevant Partnership Share
 Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.4 **Holding Period and Trustee authorisation**:
 The provisions of Rules 2.1, 8 and 11 of Part Two of the Schedule and Clause 11.3
 of the Deed shall apply with the necessary amendments in respect of Matching Shares offered
 under this Part Four of the Schedule.

**<u>PART FIVE</u>**

**<u>Deed of Adherence</u>**

THIS DEED is made this day of 20[ ]

BETWEEN

ASTRAZENECA PLC ("the Company"); [ ]("the Trustee"); and [New Participating Company] and is supplemental to the Trust Deed and Rules ("the Trust Deed") of the AstraZeneca All-Employee Share Plan ("the Plan") executed by the Company and the Trustee on the [ ] 2000.

WHEREAS:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) [New Participating Company]
 was incorporated on the [ ]
 day of [ ]
 and on the [ ]
 day of [ ]
 became a Subsidiary of the Company;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) [New Participating Company] wishes to become
 a Participating Company under, and to invite its Eligible Employees to participate in, the
 Plan.

NOW THIS DEED WITNESSETH as follows:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) Terms and expressions used in this deed
 of adherence shall, unless the context otherwise requires, have the same meaning as in the
 Trust Deed.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) [New Participating Company] agrees to become
 a Participating Company and to be bound by the terms of the Trust Deed.

IN WITNESS of which this Deed of Adherence has been delivered as a deed on the date written above.

---

| | |
|:---|:---|
| EXECUTED AND DELIVERED | EXECUTED AND DELIVERED |
| AS A DEED BY [NEW PARTICIPATING COMPANY] | AS A DEED BY [NEW PARTICIPATING COMPANY] |
| | Director |
| | Director/Secretary |
| EXECUTED AND DELIVERED | EXECUTED AND DELIVERED |
| **AS A DEED BY ASTRAZENECA PLC** | **AS A DEED BY ASTRAZENECA PLC** |
| | Director |
| | Director/Secretary |
| EXECUTED AND DELIVERED | EXECUTED AND DELIVERED |
| AS A DEED BY | AS A DEED BY |
| | Director |
| | Director/Secretary |

---

---

| | |
|:---|:---|
| EXECUTED AND DELIVERED | EXECUTED AND DELIVERED |
| **AS A DEED by ASTRAZENECA PLC** | **AS A DEED by ASTRAZENECA PLC** |
| | Director |
| | Authorised Signatory |
| EXECUTED AND DELIVERED | EXECUTED AND DELIVERED |
| AS A DEED by | AS A DEED by |
| | Director |
| | Secretary |

---

## Exhibit 4.9

**Exhibit 4.9**

**Rules of the AstraZeneca SharePlus Plan**

**Adopted by RemCo on 8 August 2025 and amended on 11 December 2025.**

**AstraZeneca SharePlus Plan (the AZ SharePlus Plan)**

*<u>What is the AZ SharePlus Plan and how can you participate?</u>*

The AZ SharePlus Plan is a global employee share purchase plan. It allows eligible employees of AZ to receive shares in AstraZeneca PLC. If AZ invites you to participate in the AZ SharePlus Plan, you may be:

&nbsp;&nbsp;&nbsp;&nbsp;(i) invited to acquire shares with deductions from net base pay, with those shares being held on your behalf
by a nominee; and

&nbsp;&nbsp;&nbsp;&nbsp;(ii) granted a Bonus Award which would entitle you to receive additional shares
as a bonus for participating in the AZ SharePlus Plan.

*<u>When do you take ownership of shares?</u>*

If you accept an invitation to participate in the AZ SharePlus Plan and complete the enrolment process, you will make contributions that are deducted from your net pay via payroll, where this is possible. Those contributions will then be used to make a market purchase of AstraZeneca PLC shares (Investment Shares).

The Investment Shares have a holding period from the date of purchase of one year or another length determined by RemCo. At the time you acquire Investment Shares, you will also be granted a Bonus Award in the form of Restricted Stock Units (RSUs) (Bonus Shares). The Bonus Award will be calculated as a percentage of your Investment Shares and will have a one year vesting period. At the end of the vesting period, the Bonus Award will be converted to Bonus Shares and will be delivered (after withholdings for tax).

If you choose to sell your Investment Shares during the one year holding period, you will forfeit any associated Bonus Award.

*<u>What happens if you leave AZ?</u>*

If you leave AZ, you will keep the Investment Shares already purchased and the holding period will expire. Unless you are dismissed for gross misconduct (or equivalent misconduct within your jurisdiction that would entitle AZ to terminate your employment without notice or pay in lieu thereof), your granted but unvested Bonus Awards will accelerate and you will receive Bonus Shares on a pro-rated basis according to the proportion of the vesting period that has expired.

If you leave AZ before the purchase of your Investment Shares, the purchase of Investment Shares will go ahead using the contributions you made to the AZ SharePlus Plan before your leaving date. No holding period will apply to the Investment Shares but you will not be granted a Bonus Award.

Once you leave AZ, you cannot make any further contributions to the AZ SharePlus Plan.

*<u>What happens on a change of control of AZ?</u>*

If there is a change of control of AZ, any holding period will end early and the Investment Shares and Bonus Shares will be released at the date of the change of control.

If a change of control will occur before the scheduled purchase of Investment Shares, Investment Shares will be purchased early using the contributions made through to the change of control and a Bonus Award will be granted which will vest at the date of the change of control.

*<u>What about dividends?</u>*

Dividends will be paid on Investment Shares (and Bonus Shares once the Bonus Award has vested) in the ordinary course and, for so long as they are held by the Nominee, will be reinvested in additional Shares (Dividend Shares).

Unvested Bonus Awards do not attract dividends or dividend equivalents.

*<u>General</u>*

The shares are personal and may not be transferred or charged until the holding period has expired. The awards do not form part of your terms and conditions of employment and are not pensionable.

You may be required to accept the grant of an award and agree to certain terms.

This summary does not form part of the Rules of the AZ SharePlus Plan. The Rules of the AZ SharePlus Plan are set out in the following pages and will govern how the Investment Shares, Bonus Award and Bonus Shares are treated. Definitions and interpretation provisions are at ‎Appendix 1.

This summary is an overview. Depending on the jurisdiction in which you are resident, the AZ SharePlus Plan may operate differently or your shares may be subject to special terms.

**Rules of the AstraZeneca SharePlus Plan**

1. **Operation of the Plan** 

1.1 The Plan will generally be operated each year with each offering lasting for a period of up to 12 months
(a **Plan Year**).

1.2 RemCo will be responsible for determining the terms on which the Plan is operated in any Plan Year in
accordance with these Rules.

2. **Form of invitation** 

2.1 AZ will invite selected Eligible Employees to join the Plan. Eligible Employees will be selected by AZ.
There is no requirement for all Eligible Employees to receive an invitation.

2.2 The invitations to join the Plan shall be made in the form determined by AZ from time to time. This may
include invitations in writing or by e-mail or internet (or other electronic means). In any Plan Year the terms of the invitations may
vary between Eligible Employees to reflect any local regulatory, securities law, taxation or any other considerations in the relevant
jurisdictions.

2.3 The invitations to join the Plan will specify:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.3.1 the minimum and maximum value of Contributions;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.3.2 the period over which Contributions may be made (the **Contribution Period**);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.3.3 the purchase date(s) for Investment Shares (the **Purchase Date(s)**);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.3.4 whether Bonus Awards will be granted and the Bonus Percentage (being the ratio of any Bonus Shares to
Investment Shares); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.3.5 the Holding Period (if any) that will apply to the Investment Shares, Bonus Shares and/or the Dividend
Shares.

2.4 If you wish to accept an invitation you must do so in the manner and within the period specified in the
invitation.

2.5 Once you have accepted an invitation, your participation in the Plan for the Plan Year will continue until
such time as you notify AZ that you wish to withdraw from the Plan, your Employment ends or you cease to be an Eligible Employee.

3. **Contributions** 

3.1 RemCo will determine (and has discretion to amend) the minimum and maximum value of Contributions which
you may make to the Plan. The minimum and maximum will generally be expressed as a monthly figure but if you are paid on a cycle that
is not monthly (bi-weekly, four weekly etc), the maximum and minimum Contributions will be adjusted accordingly. The minimum and maximum
value of Contributions may also be adjusted depending on your jurisdiction.

<u>Payroll Contributions</u>

3.2 Contributions will generally be deducted via payroll and shall be processed as follows:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Contributions shall be deducted from your net Base Pay on each pay date after your acceptance has taken
effect or on such other date(s) as RemCo may decide.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Contributions may be accumulated over such period of time as may be determined by RemCo before they are
used to acquire Investment Shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Contributions are made after any deductions for tax and social security contributions.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) Contributions shall cease if:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) you notify AZ that you wish to withdraw from the Plan pursuant to Rule ‎3.9;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) you cease to be an Eligible Employee; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) your Employment ends.

<u>Other Contributions</u>

3.3 Where local rules prohibit the deductions from Base Pay needed for Payroll Contributions, you may
be permitted to make Other Contributions.

3.4 You may also be permitted to make Other Contributions if RemCo so decides from time to time.

3.5 Your Other Contributions, when added to any Payroll Contributions, must not exceed the maximum limit of
Contributions. If your Contributions exceed this limit, AZ may take such steps as it considers appropriate including but not limited to
pausing your Contributions for a period or repaying any excess amount to you.

3.6 Contributions made in a currency other than GBP or USD (including any limits which apply to Contributions)
will be converted into GBP or USD on such date or dates and at such rates as determined by AZ.

3.7 Contributions will be held by the Nominee, AZ or any relevant member of AZ Group in a non-interest bearing
account until they are used to acquire Investment Shares on your behalf pursuant to the Rules.

<u>Changing Contributions, Stopping Contributions and Withdrawing Contributions</u>

3.8 You may not change the value of your Contributions during a Plan Year.

3.9 You may give notice to stop your Contributions at any point. Your Contributions will be stopped as soon
as administratively possible. If you give notice to stop your Contributions, any existing Contributions will be used to acquire Investment
Shares on the next Purchase Date.

3.10 If you give notice to stop Contributions you may not re-start Contributions in that Plan Year.

4. **Purchase of Investment Shares** 

4.1 On or as soon as reasonably practicable following each Purchase Date, AZ shall procure the acquisition
of Investment Shares on your behalf.

4.2 The number of Investment Shares purchased on your behalf on any Purchase Date will be the number that
can be acquired using your available Contributions at the prevailing market price.

4.3 Unless RemCo determines otherwise, the Investment Shares will be held on your behalf by the Nominee during
the Holding Period.

4.4 You may sell, transfer, assign, charge, pledge or otherwise encumber or dispose of the Investment Shares
at any time, but doing so before the expiry of the Holding Period will result in you forfeiting the related Bonus Award.

5. **Bonus Award and Bonus Shares** 

5.1 If you acquire Investment Shares under the Plan on a Purchase Date, on or as soon as reasonably practicable
following that Purchase Date, AZ will grant you a Bonus Award over Bonus Shares.

5.2 A Bonus Award will vest on the Vesting Date over a number of Bonus
Shares calculated as follows:

Bonus Percentage X the number of Investment Shares you acquired on the applicable Purchase Date.

5.3 If you sell, transfer, assign, charge, pledge or otherwise encumber or dispose of the Investment Shares
to which the Bonus Award relates before the expiry of the Holding Period, your Bonus Award will lapse.

5.4 A Bonus Award will not vest unless the following conditions are satisfied:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the vesting of a Bonus Award and the issue or transfer of Bonus Shares following such vesting must be
lawful in all relevant jurisdictions and in compliance with the applicable listing rules, any relevant share dealing code of AZ, any other
relevant UK or overseas regulation or enactment;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) if, on the vesting of a Bonus Award, a Tax Liability would arise by virtue
of such vesting and RemCo decides that such Tax Liability shall not be satisfied by the sale of Shares pursuant to Rule ‎7,
then you must have entered into arrangements acceptable to RemCo that the relevant member of the AZ Group will receive the amount of such
Tax Liability;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) you have entered into such arrangements as RemCo requires (and where permitted in the relevant jurisdiction)
to satisfy a member of the AZ Group's liability to social security contributions in respect of the vesting of the Bonus Award; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) where RemCo requires, you have entered into, or agreed to enter into, a valid election under the relevant
overseas jurisdiction's equivalent of Part 7 of ITEPA (Employment income: elections to disapply tax charge on restricted securities).

For the purpose of this paragraph, references to member of the AZ Group include a former member of the AZ Group.

5.5 As soon as practicable after the vesting of a Bonus Award, the number of
Bonus Shares in respect of which it has vested, after any sale or withholding of Shares to meet any Tax Liability, will, subject to Rule ‎7,
be transferred to the Nominee to hold on your behalf .

5.6 Notwithstanding any other provision, RemCo may, at any time, determine that a Bonus Award shall not be
satisfied by the transfer of Bonus Shares but will be satisfied by the payment to you of a cash sum equal to the Market Value of the Bonus
Shares in respect of which a Bonus Award vests on the day of vesting (converted into your relevant payroll currency at an appropriate
spot rate) less deductions for Tax Liabilities.

6. **Dividend Shares** 

6.1 Any dividends (net of any withholding tax) paid on Investment Shares where the record date falls after
the Purchase Date will be reinvested in Dividend Shares on such basis as AZ may determine.

6.2 You will have no right to dividends or dividend equivalents in respect of the Bonus Award prior to the
Vesting Date. Any dividends (net of any withholding tax) paid on Bonus Shares where the record date falls after the Vesting Date will
be reinvested in Dividend Shares on such basis as AZ may determine.

6.3 Dividend Shares will be held by the Nominee on your behalf.

7. **Tax** 

7.1 If AZ will, or is likely to, incur any Tax Liability in connection with your participation in the Plan
then you must enter into arrangements acceptable to any relevant member of the AZ Group to secure that it receives an amount equal to
such Tax Liability. If no such arrangement is made then you will be deemed to have authorised AZ to sell or procure the sale of sufficient
of the Investment Shares or Bonus Shares subject to a Bonus Award on your behalf to ensure that the relevant member of the AZ Group receives
the amount required to discharge such Tax Liability. For the purpose of this paragraph, references to member of the AZ Group include a
former member of the AZ Group.

7.2 By accepting an invitation to participate in the Plan, you indemnify AZ and your employer against any
Tax Liabilities that may arise in connection with the benefits delivered under the Plan. AZ or your employer may withhold any amount and
make any arrangements it considers necessary to meet any Tax Liabilities, which may include the sale on your behalf of any Shares acquired
by you under the Plan.

8. **End of Employment** 

8.1 You may not make further Contributions after the date your Employment ends.

8.2 If your Employment ends because you are dismissed for Gross Misconduct:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.2.1 any granted but unvested Bonus Awards will lapse and you will cease to have any entitlement to Bonus Shares;
and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.2.2 your accrued but unused Contributions will be used to purchase Investment
Shares at the next Purchase Date but you will not be granted a Bonus Award in accordance with Rule ‎5.

8.3 If your Employment ends for any reason other than because you are dismissed for Gross Misconduct:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.3.1 the Holding Period attached to any Investment Shares already purchased and held on your behalf by the
Nominee will expire on the date your Employment ends;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.3.2 any granted but unvested Bonus Awards will, subject to Rule ‎ 5.3,
accelerate and the Bonus Shares will vest on a pro-rated basis according to the proportion of the Vesting Period that has expired on the
date your Employment ends; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.3.3 your accrued but unused Contributions will be used to purchase Investment
Shares at the next Purchase Date, but no Holding Period will apply to such Investment Shares and you will not be granted a Bonus Award
in accordance with Rule ‎5.

8.4 Your Shares will be transferred to you or your nominee as soon as practicable following the date your
Employment ends unless you separately agree to hold your Shares through the Nominee designated by AZ.

8.5 For the purposes of this Rule ‎8, if you are on statutory
family-related leave, your Employment will not end until the earlier of the date on which you notify your employer of your intention not
to return to work or the date on which you cease to have statutory or contractual rights to return to work.

8.6 If you are resident in China and you end Employment as a result of your death, if a delay in providing
the necessary documentation will result in a breach of the Chinese State Administration of Foreign Exchange requirements, your Award shall
not be satisfied by the issue or transfer of Shares but will be satisfied by the payment of a cash sum equal to the Market Value of the
Shares in respect of which your Award vested under Rule **8.3.** (converted into your relevant payroll
currency at an appropriate spot rate) less deductions for Tax Liabilities.

9. **Lapse of Awards** 

9.1 Notwithstanding any other provision of these Rules, all Awards will lapse:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;9.1.1 if you are declared bankrupt or are unable to hold an Award by operation
of law, or you attempt to transfer, assign, charge or dispose of an Award contrary to Rule ‎14.3;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;9.1.2 to the extent that the Award does not vest in full under Rules ‎8
or ‎10.

10. **Change of Control of AZ** 

10.1 If:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10.1.1 an offeror (alone or with any party acting in concert with the offeror) obtains Control of AZ by making
an offer to acquire the whole of the issued ordinary share capital of AZ (or any part of it which is not owned by the offeror and any
party acting in concert with the offeror);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10.1.2 the Court sanctions a compromise or arrangement affecting the Shares under section 899 of the Companies
Act 2006; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10.1.3 a resolution is passed for the voluntary winding up of AZ, (each being a  ***Change of Control Event***),

the Holding Period in respect of your Investment Shares shall be deemed expired and your Bonus Award shall Vest on the date of the Change of Control Event.

10.2 If a Change of Control Event occurs before the Purchase Date, AZ shall procure the acquisition of Investment
Shares on your behalf as soon as reasonably practicable using the Contributions made up to and including the date of the Change of Control
Event. AZ will grant you a Bonus Award as soon as reasonably practicable over a number of Bonus Shares (calculated using the method set
out in Rule ‎ 5.2) and that Bonus Award will Vest on the date of the Change of Control Event.

11. **Amending the Plan and Awards** 

11.1 If there is a Variation in the equity share capital of AZ, the number and/or the nominal value of the
Shares over which an Award is granted will be adjusted as RemCo decides. You will be notified of any adjustment.

11.2 AZ can amend these Rules at any time.

11.3 AZ can adopt additional sections of these Rules applicable in any jurisdiction under which Awards
may be subject to additional and/or modified terms and conditions, taking into account any securities, exchange control or taxation laws,
which may apply to you, AZ, or any member of the AZ Group. Any additional sections must conform to the basic principles of the Plan.

12. **Source of Shares** 

12.1 Any Shares you receive as Investment Shares, Bonus Shares or Dividend Shares under the Plan will be Shares
that are purchased in the market, and will not be Shares that are treasury shares or are newly issued to you.

13. **Administration** 

13.1 The Plan will be administered by RemCo which will interpret and construe any provision of the Plan and
may adopt any regulations for administering the Plan and any documents it thinks appropriate. The decision of RemCo on any matter concerning
the Plan will be final and binding.

13.2 Any communication in connection with the Plan (including any award documentation) can be given electronically
by e-mail or on an online portal designed for the purpose or by personal delivery or post, (in the case of a company, to its registered
office and in the case of an individual to the individual's last known address) or by any other means which AZ and you use to communicate
with each other.

13.3 Any notice under the Plan will be given: (i) if delivered personally, at the time of delivery; (ii) if
posted, at 10.00 a.m. on the third business day after it was put into the post; or (iii) if sent by e-mail or any other form
of electronic delivery system, at the time of despatch.

14. **General** 

14.1 You may be required to accept the grant of an Award and agree to its terms, in which case AZ will notify
you of this requirement. If you fail to accept an Award and agree to its terms within any time period notified to you, RemCo shall have
the discretion to lapse the Award without further notice to you or to apply any additional conditions to the vesting of the Bonus Award
or Bonus Shares received on vesting of the Bonus Award as it may determine.

14.2 For the avoidance of doubt, by participating in the Plan, you specifically represent, warrant and acknowledge
that you have read and understood the terms and conditions of the Plan, including as set out in Rule ‎ 8,
which:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;14.2.1 states that you shall have no entitlement to damages or other compensation whatsoever arising from, in
lieu of, or related to not receiving any Awards which would have vested or been granted after your Employment ends including but not limited
to damages in lieu of notice of termination at common law or civil law (as applicable) and you waive such entitlements; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;14.2.2 have the effect that no period of contractual, common law or civil law (as applicable) reasonable notice
of termination that, if required pursuant to applicable laws, exceeds your minimum statutory notice of termination period under applicable
employment standards legislation (if any), shall be used for the purposes of calculating your entitlement under the Plan.

14.3 By participating and receiving the Awards you further waive any eligibility to receive damages or payment
in lieu of any forfeited Awards under the Plan that would have vested or accrued during any contractual, common law or civil law reasonable
notice of termination period that, if required pursuant to applicable laws, exceeds your minimum statutory notice of termination period
under the applicable employment standards legislation (if any). Your participation in the Plan may be conditional on you agreeing to hold
your Shares through the Nominee designated by AZ.

14.4 Your Awards may not be sold, transferred, assigned, charged or otherwise encumbered or disposed of to
any person, other than to your personal representatives on your death.

14.5 You must comply with the Dealing Restrictions at all times, including when accepting an invitation to
participate in the Plan pursuant to Rule ‎ 2.4 and when giving notice to stop your Contributions
pursuant to Rule ‎ 3.9. Failure to comply with the Dealing Restrictions will invalidate your
actions.

14.6 Participation in the Plan is not pensionable and does not form part of your employment contract. Benefits
delivered under the Plan do not form part of your salary for any purpose and shall not be taken into account when calculating any payments
due in respect of notice, severance, termination, or similar.

14.7 Nothing in the Plan or any document under it will give any person any right to participate in the Plan
and the grant of an Award does not create any right or expectation to the grant of an Award in the future. Your rights and obligations
under the terms of your office or Employment will not be affected by participation in the Plan or any right which you may have to participate
under it.

14.8 By participating in the Plan, you waive all and any rights to compensation or damages under the Plan in
consequence of any loss of rights under the Plan as a result of: (i) termination of your office or Employment with a member of the
AZ Group for any reason; or (ii) the way in which RemCo or any person to whom RemCo has delegated authority, exercises or does not
exercise any discretion under the Plan. Nothing in the Plan or in any document executed under it will give you any right to continue in
Employment or will affect the right of any member of the AZ Group to terminate your Employment without liability at any time with or without
cause.

14.9 The invalidity or non-enforceability of one or more provisions of the Plan will not affect the validity
or enforceability of the other provisions of the Plan, which will remain in full force and effect.

14.10 The Plan was adopted by RemCo on 8 August 2025 and amended on 11 December 2025. The Plan will
terminate when revoked by RemCo. Termination of the Plan will not affect your existing Awards.

14.11 Nothing in this Plan confers any benefit, right or expectation on a person who is not an Eligible Employee
or member of the AZ Group, and no third party has any rights under the Contracts (Rights of Third Parties) Act 1999 to enforce any term
of this Plan. This does not affect any other right or remedy of a third party which may exist.

14.12 These Rules will be governed by and construed in accordance with the laws of England. You, AZ and
any member of the AZ Group submit to the jurisdiction of the English courts in relation to anything arising under the Plan. RemCo may
determine that another law will apply to the operation of the Plan outside the United Kingdom.

**Appendix 1**

**Definitions and Interpretation**

**Award** means a Bonus Award and/or an award of Investment Shares;

**AZ** means AstraZeneca PLC (registered number 2723534);

**AZ Group** means AZ and any subsidiary, holding company or subsidiary of a holding company of AZ (as each term is defined in section 1159 Companies Act 2006);

**Base Pay** means basic salary or any such remuneration paid or made available by an employing company as determined by the RemCo generally or on an individual country basis;

**Bonus Award** means an award of Bonus Shares granted or proposed to be granted under Rule ***‎***5;

**Bonus Percentage** means the percentage specified in the invitation to join the Plan to determine the number of Bonus Shares under a Bonus Award relative to the number of Investment Shares acquired;

**Bonus Shares** means Shares acquired on vesting of a Bonus Award;

**Business Day** means a day on which the New York Stock Exchange (or, if relevant and if RemCo determines, any stock exchange nominated by RemCo on which the Shares are traded) is open for the transaction of business;

**Contribution Period** means the period to the Purchase Date during which Contributions may be made to the Plan;

**Contributions** means Payroll Contributions or Other Contributions;

**Control** shall have the meaning given in section 995 Income Tax Act 2007;

**Dealing Restrictions** means AZ's code for dealing in shares by its directors and applicable employees (as amended from time to time) in accordance with relevant legislation or regulation and any other agreement, arrangement, contract or code adopted or entered into by AZ containing provisions similar in purpose and effect;

**DI** means a depositary interest issued through CREST representing a beneficial interest in an ordinary share in the capital of AZ;

**Eligible Employee** means any person who at a Grant Date is:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) an employee of any member of the AZ Group but not an executive director of AZ; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) satisfies any other conditions specified by the Nominee (if any) in relation to any employee or group
of employees;

**Employment** means employment as an employee of any member of the AZ Group;

**Gross Misconduct** means, except for participants who are resident of Canada, any act or omission that would entitle AZ to terminate your Employment immediately and with no liability to make any further payment to you (other than in respect of amounts accrued due at the date of termination). For participants who are resident of Canada, **Gross Misconduct** means (i) the same as 'Cause' (or words of like import) in a written employment agreement between you and the applicable AZ Group entity, which contains an enforceable contractual termination provision (the "**Employment Agreement**"), or (ii) if you are not subject to such an Employment Agreement, (a) if you are employed in Ontario or Nova Scotia, your wilful misconduct, disobedience or wilful neglect of duty that is not trivial and has not been condoned by the applicable AZ Group entity; or (b) if you are employed in any other province in Canada, any other act or omission or series of acts or omissions by you that would, pursuant to applicable law, permit the applicable AZ Group entity to terminate your employment without notice or payment in lieu of notice, including for serious reason.

**Holding Period** means the period from the Purchase Date to the Vesting Date, or such other period as RemCo may determine which may not be less than three months or more than two years, during which you cannot dispose of the Investment Shares;

**Investment Shares** means Shares which are acquired on your behalf using your Contributions;

**Market Value** means, in relation to an ordinary share on any day, an amount equal to the average of the middle market closing prices of a Share (as derived from the New York Stock Exchange Listings Directory) on the three consecutive Dealing Days preceding that day (or such other Dealing Day or Dealing Days as RemCo may decide) or, in the case of a DI, by reference to the average of the equivalent price of a DI as derived from the Daily Official List of the London Stock Exchange plc on trading days as close as possible to those Dealing Days. In the event that the ordinary shares cease to be traded on the New York Stock Exchange and are admitted to trading on a replacement market, references to the New York Stock Exchange shall be construed as references to the equivalent of such replacement market. In the event that DIs cease to be traded on the Main Market of the London Stock Exchange and are admitted to trading on a replacement market, references to the London Stock Exchange shall be construed as references to such replacement market;

**Payroll Contributions** means regular deductions from Base Pay for the purpose of acquiring Investment Shares;

**Nominee** means the registered holder of the Investment Shares, Bonus Shares and Dividend Shares appointed by AZ or the AZ Group for the purpose of the Plan;

**Other Contributions** means monthly cash or other payments for the purpose of acquiring Investment Shares on such terms as the RemCo determines;

**Plan** means the AstraZeneca SharePlus Plan constituted by these Rules;

**Purchase Date** means the date(s) specified in the invitation to join the Plan on which Investment Shares will be purchased;

**Restricted Person** means any person who is classified as a restricted person, a permanent insider, a PDMR, a person with access to inside information or any other person who is restricted from dealing in Shares by any Dealing Restriction;

**Rules** means the rules of this Plan as set out in this document, and "Rule" shall be construed accordingly;

**RemCo** means the duly authorised remuneration committee of the board of directors of AZ;

**Share** means a fully paid ordinary share in the capital of AZ or, where the context requires it, an equivalent number of DIs;

**Tax Liabilities** means any income tax, national insurance contributions, social security charges or similar taxes or charges imposed in any jurisdiction for which AZ or any member of the AZ Group is required to account;

**Variation** means a capitalisation issue, rights issue, subdivision, consolidation, reduction, or any other variation in the capital of AZ;

**Vesting** means you becoming entitled to have the Shares subject to a Bonus Award transferred to you subject to the Plan, and "Vest", and "Vested" shall be construed accordingly; and

**Vesting Date** means the date on which a Bonus Award will vest which will, unless the RemCo determines otherwise and provides for such differing Vesting Date in the invitation for any Eligible Employee, be the first anniversary of the Purchase Date, and "Vesting Period" shall be construed accordingly.

**Interpretation**

Headings are for convenience only. Words in the singular include the plural and vice versa and words importing gender include both genders. Reference to statutory provisions include amendments, extensions or re-enactments and equivalent legislation in any country other than England, and include any regulations or subordinate legislation made under them.

**Appendix 2**

**Schedule for US Participants**

This Appendix 2 ("**Appendix 2**") modifies the Rules of the Plan in respect of any Awards granted under it to Eligible Employees who are resident in the U.S. or who are otherwise subject to U.S. taxation. Capitalized terms not defined in Appendix 2 will have the same meaning ascribed to them in the Plan and Appendix 1. To the extent there is any conflict between the Plan and Appendix 2, the terms of Appendix 2 shall prevail.

1. Rule ‎2.5 shall be deleted and replaced with the following:

"For any Plan Year for which you will be invited to join the Plan, you will be provided with an invitation in the calendar year prior to the calendar year in which such Plan Year begins. If you choose to accept such invitation, you must accept such invitation and elect your monthly Contribution amount and the amount of any Other Contributions, in each case, no later than the end of the calendar year in which you were provided the invitation. Your participation will continue until such time as you notify AZ that you wish to withdraw from the Plan or your Employment ends."

2. The following shall be inserted as a new Rule‎2.3.6:

"the applicable deadline for your election to join the Plan and determine the Contribution amount."

3. In Rule ‎2.3.5, the words "Holding Period (if any)" shall be deleted and replaced
by "Holding Period and Vesting Date (if any, in each case)".

4. The following sentence shall be appended to the end of the existing Rule ‎5.5:

"In no event shall the Bonus Shares be so transferred later than the end of the calendar year in which the applicable Vesting Date occurs, notwithstanding any delays contemplated in Rule ‎5.4. If the RemCo determines that the Bonus Shares cannot be transferred by this deadline, including due to the reasons set forth in Rule ‎5.4, your Bonus Award will be satisfied by the payment to you of a cash sum equal to the Market Value of the Bonus Shares that vested in that calendar year (converted into your relevant payroll currency at an appropriate spot rate) less deductions for Tax Liabilities."

5. Rule ‎8.4 shall be deleted and replaced with the following:

"If your employment ends, all of your vested Shares will be transferred to you or your nominee as soon as practicable following but no later than the end of the calendar year in which your Employment ends."

6. Rule ‎8.5 shall be deleted and replaced with the following:

"For the purposes of this Rule ‎8, if you are on an authorized leave of absence pursuant to an AZ policy or a legal entitlement, you will end Employment on the expiration of the six-month term beginning with the first day of such leave of absence, unless (i) you have a statutory or contractual right to return to work following such six-month period, in which case, your Employment will not end until you cease to have such statutory or contractual right, or (ii) you are on leave due to Disability, in which case, your Employment will not end until the earlier of (a) the 29-month anniversary of the start of such leave of absence and (b) the day that you or your employer terminates the employment relationship."

7. In ‎Appendix 1 (Definitions) the following definition shall be inserted:

"Disability means any medically determinable physical or mental impairment that can be expected to result in death or can be expected to last for a continuous period of not less than six months, where such impairment causes you to be unable to perform the duties of your position of employment or any substantially similar position of employment."

8. Your Bonus Award shall vest and a new Bonus Award and Bonus Shares will provided in accordance with Rule ‎ 10
only if the applicable event described therein also constitutes a "change in control event" under Section 409A of the
US Internal Revenue Code of 1986, as it may be amended from time to time, and all regulations, interpretations and administrative guidance
issued thereunder (the "Code"). If Rule ‎ 10 applies to an event, any Bonus Shares
owing to you pursuant to Rule 10 shall be transferred to you or your nominee no later than the end of the calendar year in which
the Change of Control Event occurs. If Rule 10 does not apply to an event because such event does not also constitute a "change
in control event" under Section 409A of the Code, your Bonus Award will be forfeited upon the Change of Control Event and will
not vest, and you will forfeit any right to any Bonus Shares otherwise owed to you pursuant to Rule 10. The purchase of Investment
Shares will occur as set forth in Rule 10 regardless of whether the Change of Control Event constitutes a "change in control
event" under Section 409A

9. The following shall be inserted as a new Rule 15:

"15. **Section 409A of the Code**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;15.1 The compensation and benefits under the Plan are intended to comply with the requirements of Section 409A
of the Code, and the Plan will be interpreted and administered in a manner consistent with that intent. The preceding provision, however,
shall not be construed as a guarantee by AZ of any particular tax effect to you under an Bonus Award. Payment may be accelerated or delayed
only if and to the extent that such accelerated or delayed payment is permitted under Section 409A of the Code.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;15.2 References to "end of Employment", "cessation of Employment", "termination
of Employment" and similar terms used in the Plan mean, to the extent necessary to comply with Section 409A of the Code, the
date that you first incur a "separation from service" within the meaning of Section 409A of the Code.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;15.3 Notwithstanding anything in the Plan to the contrary, if at the time of your separation from service with
AZ you are a "specified employee" as defined in Section 409A of the Code, and any payment payable under the Plan as a
result of such separation from service is required to be delayed by six months pursuant to Section 409A of the Code, then AZ will
make such payment on the date that is six months following your separation from service with AZ. The amount of such payment will equal
the sum of the payments that would have been paid to you during the six-month period immediately following your separation from service
had the payment commenced as of such date and will not include interest.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;15.4 No Bonus Shares issued or payments made in respect of any Bonus Award shall be funded with any assets
set aside in a trust or other arrangement in violation of Section 409A(b)(1) of the Code. To the extent any trust is utilized
in administration of the Plan, Bonus Awards granted to Eligible Employees who are US taxpayers need not be settled by Shares held in such
a trust and such Bonus Awards do not form the basis for any claims or rights with respect to such a trust's assets.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;15.5 Bonus Awards under the Plan with respect to Investment Shares purchased with respect to Contributions
elected while you are not subject to US federal income taxation but that are paid at a time when you subsequently have become subject
to US federal income taxation are intended to be exempt from Section 409A of the Code. This clause will be interpreted consistent
with the requirements of Section 409A of the Code, including Section 1.409A-1(b)(8)(ii) of the US Treasury Regulations,
as well as any subsequent guidance under Section 409A of the Code."

## Exhibit 5.1

**Exhibit 5.1**

2 February, 2026

Securities and Exchange Commission

100 F Street, NE

Washington, D.C. 20549

Ladies and Gentlemen:

In connection with this Registration Statement on Form S-8 (the "Registration Statement") to register under the Securities Act of 1933, as amended, 1,951,945 Ordinary Shares, par value $0.25 each of AstraZeneca PLC (the "Shares"), deliverable pursuant to the AstraZeneca Savings Related Share Option Scheme and AstraZeneca Share Incentive Plan (together, the "Plans"), I have examined originals or copies, certified or otherwise identical to my satisfaction of such documents, corporate records, certificates of public officials and other instruments as I have deemed necessary for the purpose of this opinion.

Upon the basis of the foregoing, I am of the opinion that the Shares, when delivered in accordance with the Plans upon receipt by AstraZeneca PLC of adequate consideration therefor, will be validly issued, fully paid and nonassessable.

I consent to the filing of this opinion as an exhibit to the Registration Statement.

---

| |
|:---|
| Very truly yours, |
| /s/ Sebastian Kramer |
| Sebastian Kramer |
| Assistant General Counsel |

---

## Exhibit 23.1

**Exhibit 23.1**

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in this Registration Statement on Form S-8 of AstraZeneca PLC of our report dated 6 February 2025 relating to the financial statements and the effectiveness of internal control over financial reporting, which appears in AstraZeneca PLC's Annual Report on Form 20-F for the year ended December 31, 2024.

/s/ PricewaterhouseCoopers LLP<br> London, United Kingdom<br> 2 February 2026

## Ex-Filing

?xml version='1.0' encoding='ASCII'? EX-FILING FEES

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| |
|:---|
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Calculation of Filing Fee Tables**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **S-8**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **ASTRAZENECA PLC**  |

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| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Security Type**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Security Class Title**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Fee Calculation Rule**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Amount Registered**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Proposed Maximum Offering Price Per Unit**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Maximum Aggregate Offering Price**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Fee Rate**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Amount of Registration Fee**  |
| 1 | Equity | Ordinary Shares, par value $0.25 each, of AstraZeneca PLC ("Ordinary Shares") | Other | 1086071 | $119.32 | $129589991.72 | 0.0001381 | $17896.38 |
| 2 | Equity | Ordinary Shares | Other | 25865874 | $186.74 | $4830193310.76 | 0.0001381 | $667049.70 |
| Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: |  | $4959783302.48  |  | $684946.08  |
| Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  |  |  |  | $0.00  |
| Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  |  |  |  | $684946.08  |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Offering Note** <br>

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <sup>1</sup> Note to Amount Registered 1(a): Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement covers any additional Ordinary Shares that may be offered or sold under the terms of the AstraZeneca Savings Related Share Option Scheme by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the Registrant's receipt of consideration which results in an increase in the number of the outstanding Ordinary Shares. Note to Amount Registered 1(b): Represents 1,086,071 Ordinary Shares that may be offered or sold upon exercise of outstanding options previously granted under the AstraZeneca Savings Related Share Option Scheme. Note to Proposed Maximum Offering Price Per Unit 1(c): Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(c) and Rule 457(h) under the Securities Act, based upon the weighted average exercise price of GBP87.80 per Ordinary Share granted under the AstraZeneca Savings Related Share Option Scheme converted into U.S. dollars at the exchange rate of $1.3590 to GBP1.0000 on January 23, 2026 as published by the Board of Governors of the Federal Reserve System.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <sup>2</sup> Note to Amount Registered 2(a): Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement covers any additional Ordinary Shares that may be offered or sold under the terms of the AstraZeneca Restricted Share Plan, AstraZeneca Global Restricted Stock Plan, AstraZeneca Extended Incentive Plan, AstraZeneca Deferred Bonus Plan, AstraZeneca Performance Share Plan 2020, AstraZeneca Savings Related Share Option Scheme, AstraZeneca Share Incentive Plan, and AstraZeneca SharePlus Plan by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the Registrant's receipt of consideration which results in an increase in the number of the outstanding Ordinary Shares. Note to Amount Registered 2(b): Includes 1,500,000 Ordinary Shares that may be offered or sold under the AstraZeneca Restricted Share Plan, 12,000,000 Ordinary Shares that may be offered or sold under the AstraZeneca Global Restricted Stock Plan, 250,000 Ordinary Shares that may be offered or sold under the AstraZeneca Extended Incentive Plan, 250,000 Ordinary Shares that may be offered or sold under the AstraZeneca Deferred Bonus Plan, 5,000,000 Ordinary Shares that may be offered or sold under the AstraZeneca Performance Share Plan 2020, 680,222 Ordinary Shares that may be offered or sold under the AstraZeneca Savings Related Share Option Scheme, 185,652 Ordinary Shares that may be offered or sold under the AstraZeneca Share Incentive Plan and 6,000,000 Ordinary Shares that may be offered or sold under the AstraZeneca SharePlus Plan. Note to Proposed Maximum Offering Price Per Unit 2(c): Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(c) and Rule 457(h) under the Securities Act, based on the average of the high and low prices per American Depositary Share, each representing one half of one Ordinary Share (an "ADS") as reported on the Nasdaq Global Select Market on January 28, 2026, of $93.37 multiplied by two (the ratio of ADSs to Ordinary Shares).

---

| | |
|:---|:---|
| | |
| **Rule 457(p)** | **Rule 457(p)** |
| Fee Offset Claims | N/A |
| Fee Offset Sources | N/A |

---