# EDGAR Filing Document

**Accession Number:** 0001446159
**File Stem:** 0001171843-25-007491
**Filing Date:** 2025-11
**Character Count:** 2689
**Document Hash:** f4816f2624fb9b5d1d4afd794cd0e045
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001171843-25-007491.hdr.sgml**: 20260326

**ACCESSION NUMBER**: 0001171843-25-007491

**CONFORMED SUBMISSION TYPE**: CORRESP

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20251121

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Predictive Oncology Inc.
- **CENTRAL INDEX KEY:** 0001446159
- **STANDARD INDUSTRIAL CLASSIFICATION:** ORTHOPEDIC, PROSTHETIC & SURGICAL APPLIANCES & SUPPLIES [3842]
- **ORGANIZATION NAME:** 08 Industrial Applications and Services
- **EIN:** 331007393
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** CORRESP

**BUSINESS ADDRESS:**
- **STREET 1:** 91 43RD STREET
- **STREET 2:** SUITE 110
- **CITY:** PITTSBURGH
- **STATE:** PA
- **ZIP:** 15201
- **BUSINESS PHONE:** 412-432-1500

**MAIL ADDRESS:**
- **STREET 1:** 91 43RD STREET
- **STREET 2:** SUITE 110
- **CITY:** PITTSBURGH
- **STATE:** PA
- **ZIP:** 15201

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Predictive Oncology Inc.
- **DATE OF NAME CHANGE:** 20190612

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Precision Therapeutics Inc.
- **DATE OF NAME CHANGE:** 20180314

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Precision Therapeutic Inc.
- **DATE OF NAME CHANGE:** 20180208

November 21, 2025

**<u>VIA EDGAR</u>**

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, NE

Washington, D.C. 20549

Attn: Lauren Nguyen, Office Chief<br> Juan Grana, Staff Attorney

---

| | |
|:---|:---|
| **Re:** | **Predictive Oncology Inc.** |
|  | **Registration Statement on Form S-3**<br> **Filed October 22, 2025**<br> **File No. 333-291021**<br> **Acceleration Request** <br> **Requested Date: November 25, 2025** <br> **Requested Time: 4:00 P.M. Eastern Time**  |

---

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, Predictive Oncology Inc. (the "***Registrant***") hereby requests that the above-referenced Registration Statement on Form S-3 (File No. 333-291021) (the "***Registration Statement***") be declared effective at the "Requested Date" and "Requested Time" set forth above, or as soon as practicable thereafter.

We request that we be notified of the effectiveness of the Registration Statement by telephone to Era Anagnosti of DLA Piper LLP (US) at (202) 799-4087. Thank you for your assistance.

---

| |
|:---|
| Very truly yours, |
| **Predictive Oncology Inc.** |
| /s/ Josh Blacher |
| Josh Blacher |
| Chief Financial Officer |

---

cc: Raymond Vennare (Chief Executive Officer, Predictive Oncology Inc.) Sara Turken (General Counsel, Predictive Oncology Inc.) Era Anagnosti (DLA Piper LLP (US))