# EDGAR Filing Document

**Accession Number:** 0001274413
**File Stem:** 0001104659-26-011921
**Filing Date:** 2026-2
**Character Count:** 10910
**Document Hash:** 4d624a95bdc327bee79e1fcf130ac64f
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-26-011921.hdr.sgml**: 20260209

**ACCESSION NUMBER**: 0001104659-26-011921

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20251231

**FILED AS OF DATE**: 20260209

**DATE AS OF CHANGE**: 20260209

**EFFECTIVENESS DATE**: 20260209

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** SECTORAL ASSET MANAGEMENT INC
- **CENTRAL INDEX KEY:** 0001274413

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** A8

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-10653
- **FILM NUMBER:** 26610379

**BUSINESS ADDRESS:**
- **STREET 1:** 1010 SHERBROOKE ST., WEST
- **STREET 2:** SUITE 1610
- **CITY:** MONTREAL
- **STATE:** A8
- **ZIP:** H3A 2R7
- **BUSINESS PHONE:** 514 849 8777

**MAIL ADDRESS:**
- **STREET 1:** 1010 SHERBROOKE ST., WEST
- **STREET 2:** SUITE 1610
- **CITY:** MONTREAL
- **STATE:** A8
- **ZIP:** H3A 2R7

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2025

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** SECTORAL ASSET MANAGEMENT INC<br>**Address:** 1010 SHERBROOKE ST. WEST<br>SUITE 1610<br>MONTREAL, A8 H3A 2R7

**Form 13F File Number:** 028-10653

**CRD Number (if applicable):** 000110345

**SEC File Number (if applicable):** 801-60079

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Marina Lalakin<br>**Title:** Chief Compliance Officer<br>**Phone:** 1-514-589-1437

**Signature, Place, and Date of Signing:**

/s/ Marina Lalakin  Montreal, A8  02-09-2026<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 74

**Form 13F Information Table Value Total:** $124752405

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| ABBOTT LABS | COM | 002824100 |  | 2944064 | 23498 | SH |  | SOLE |  | 23498 | 0 | 0 |
| ABBVIE INC | COM | 00287Y109 |  | 3838632 | 16800 | SH |  | SOLE |  | 16800 | 0 | 0 |
| ALIGNMENT HEALTHCARE | COM | 01625V104 |  | 622125 | 31500 | SH |  | SOLE |  | 31500 | 0 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 |  | 1188973 | 2990 | SH |  | SOLE |  | 2568 | 0 | 422 |
| AMGEN INC | COM | 031162100 |  | 4277942 | 13070 | SH |  | SOLE |  | 11980 | 0 | 1090 |
| AMICUS THERAPEUTICS | COM | 03152W109 |  | 616592 | 43300 | SH |  | SOLE |  | 38000 | 0 | 5300 |
| ARCUS BIOSCIENCES | COM | 03969F109 |  | 1356999 | 56945 | SH |  | SOLE |  | 54000 | 0 | 2945 |
| ARGENX SE SPN ADR | SP ADR | 04016X101 |  | 2433710 | 2894 | SH |  | SOLE |  | 2685 | 0 | 209 |
| ARRIVENT BIOPHARMA | COM | 04272N102 |  | 769691 | 38255 | SH |  | SOLE |  | 36840 | 0 | 1415 |
| ARS PHARMACEUTICALS | COM | 82835W108 |  | 347205 | 29803 | SH |  | SOLE |  | 26000 | 0 | 3803 |
| ASCENDIS PHARMA | SP ADR | 04351P101 |  | 693883 | 3254 | SH |  | SOLE |  | 2800 | 0 | 454 |
| ASTRAZENECA | SP ADR | 046353108 |  | 1400277 | 15232 | SH |  | SOLE |  | 13080 | 0 | 2152 |
| AXSOME THERAPEUTICS | COM | 05464T104 |  | 317794 | 1740 | SH |  | SOLE |  | 1500 | 0 | 240 |
| BEONE MEDICINES LTD | SP ADR | 07725L102 |  | 809654 | 2665 | SH |  | SOLE |  | 2285 | 0 | 380 |
| BIOGEN INC | COM | 09062X103 |  | 379259 | 2155 | SH |  | SOLE |  | 1850 | 0 | 305 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 |  | 646599 | 10880 | SH |  | SOLE |  | 9450 | 0 | 1430 |
| BIONTECH SE | SP ADR | 09075V102 |  | 1639154 | 17218 | SH |  | SOLE |  | 16260 | 0 | 958 |
| BOSTON SCIENTIFIC | COM | 101137107 |  | 2634139 | 27626 | SH |  | SOLE |  | 27626 | 0 | 0 |
| BOUNDLESS BIO INC | COM | 10170A100 |  | 814289 | 678574 | SH |  | SOLE |  | 678574 | 0 | 0 |
| BRIDGEBIO PHARMA | COM | 10806X102 |  | 854393 | 11170 | SH |  | SOLE |  | 9600 | 0 | 1570 |
| CARLSMED INC | COM | 14280C105 |  | 589095 | 47700 | SH |  | SOLE |  | 47700 | 0 | 0 |
| COGENT BIOSCIENCES INC | COM | 19240Q201 |  | 1160971 | 32685 | SH |  | SOLE |  | 31100 | 0 | 1585 |
| CONTINEUM THERAPEUTICS | CL A | 21217B100 |  | 9152995 | 800787 | SH |  | SOLE |  | 800787 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 374441 | 5893 | SH |  | SOLE |  | 5080 | 0 | 813 |
| DANAHER CORP | COM | 235851102 |  | 2420829 | 10575 | SH |  | SOLE |  | 10575 | 0 | 0 |
| DEXCOM INC | COM | 252131107 |  | 1904819 | 28700 | SH |  | SOLE |  | 28700 | 0 | 0 |
| EDWARDS LIFESCIENCE | COM | 28176E108 |  | 1470563 | 17250 | SH |  | SOLE |  | 17250 | 0 | 0 |
| EVOMMUNE INC | COM SHS | 30054Y107 |  | 10083766 | 589005 | SH |  | SOLE |  | 589005 | 0 | 0 |
| GILEAD SCIENCES INC | COM | 375558103 |  | 2195205 | 17885 | SH |  | SOLE |  | 15330 | 0 | 2555 |
| HINGE HEALTH INC | CL A | 433313103 |  | 659869 | 14206 | SH |  | SOLE |  | 14206 | 0 | 0 |
| ILLUMINA INC | COM | 452327109 |  | 324227 | 2472 | SH |  | SOLE |  | 2132 | 0 | 340 |
| IMMATICS NV | SHS | N44445109 |  | 661658 | 63015 | SH |  | SOLE |  | 59900 | 0 | 3115 |
| INCYTE CORPORATION | COM | 45337C102 |  | 271618 | 2750 | SH |  | SOLE |  | 2350 | 0 | 400 |
| INSMED INC | COM PAR $.01 | 457669307 |  | 1946115 | 11182 | SH |  | SOLE |  | 10100 | 0 | 1082 |
| INSPIRE MED SYS INC | COM | 457730109 |  | 664056 | 7200 | SH |  | SOLE |  | 7200 | 0 | 0 |
| INTUITIVE SURGIC INC | COM NEW | 46120E602 |  | 2746846 | 4850 | SH |  | SOLE |  | 4850 | 0 | 0 |
| IONIS PHARMACEUTICAL | COM | 462222100 |  | 661755 | 8365 | SH |  | SOLE |  | 7200 | 0 | 1165 |
| JAZZ PHARMA PLC | SHS USD | G50871105 |  | 348330 | 2049 | SH |  | SOLE |  | 1750 | 0 | 299 |
| JOHNSON  JOHNSON | COM | 478160104 |  | 4201085 | 20300 | SH |  | SOLE |  | 20300 | 0 | 0 |
| KURA ONCOLOGY | COM | 50127T109 |  | 562203 | 54110 | SH |  | SOLE |  | 51650 | 0 | 2460 |
| LENZ THERAPEUTICS INC | COM | 52635N103 |  | 680000 | 42500 | SH |  | SOLE |  | 42500 | 0 | 0 |
| ELI LILLY  CO | COM | 532457108 |  | 7819372 | 7276 | SH |  | SOLE |  | 7276 | 0 | 0 |
| MADRIGAL PHARMA | COM | 558868105 |  | 204984 | 352 | SH |  | SOLE |  | 305 | 0 | 47 |
| MERCK  CO INC | COM | 58933Y105 |  | 2252564 | 21400 | SH |  | SOLE |  | 21400 | 0 | 0 |
| MINERALYS THERAPEUTICS | COM | 603170101 |  | 1147671 | 31625 | SH |  | SOLE |  | 29900 | 0 | 1725 |
| MODERNA INC | COM | 60770K107 |  | 147598 | 5005 | SH |  | SOLE |  | 4350 | 0 | 655 |
| NEKTAR THERAPEUTICS | COM NEW | 640268306 |  | 570146 | 13485 | SH |  | SOLE |  | 12800 | 0 | 685 |
| NEUROCRINE BIOSCIENCES | COM | 64125C109 |  | 379395 | 2675 | SH |  | SOLE |  | 2300 | 0 | 375 |
| OMADA HEALTH INC | COM | 68170A108 |  | 575970 | 36500 | SH |  | SOLE |  | 36500 | 0 | 0 |
| ORIC PHARMACEUTICALS | COM | 68622P109 |  | 183886 | 22480 | SH |  | SOLE |  | 19100 | 0 | 3380 |
| PFIZER INC | COM | 717081103 |  | 676035 | 27150 | SH |  | SOLE |  | 27150 | 0 | 0 |
| PRIVIA HEALTH GROUP | COM | 74276R102 |  | 616460 | 26000 | SH |  | SOLE |  | 26000 | 0 | 0 |
| PTC THERAPEUTICS | COM | 69366J200 |  | 586031 | 7715 | SH |  | SOLE |  | 6650 | 0 | 1065 |
| RADNET INC | COM | 750491102 |  | 784850 | 11000 | SH |  | SOLE |  | 11000 | 0 | 0 |
| RAPPORT THERAPEUTICS | COM | 75383L102 |  | 1180984 | 38925 | SH |  | SOLE |  | 36530 | 0 | 2395 |
| REGENERON PHARMCTCLS | COM | 75886F107 |  | 2867497 | 3715 | SH |  | SOLE |  | 3363 | 0 | 352 |
| ROIVANT SCIENCES LTD | SHS | G76279101 |  | 984030 | 45347 | SH |  | SOLE |  | 39000 | 0 | 6347 |
| ROYALTY PHARMA PLC | SHS CLASS A | G7709Q104 |  | 327281 | 8470 | SH |  | SOLE |  | 7200 | 0 | 1270 |
| SHOULDER INNOVATIONS | COMMON STOCK | 82537J108 |  | 7041821 | 492435 | SH |  | SOLE |  | 492435 | 0 | 0 |
| STRUCTURE THERAPEUTICS | SP ADR | 86366E106 |  | 1660298 | 23872 | SH |  | SOLE |  | 23227 | 0 | 645 |
| STRYKER CORP | COM | 863667101 |  | 2302129 | 6550 | SH |  | SOLE |  | 6550 | 0 | 0 |
| SUMMIT THERAPEUTICS | COM | 86627T108 |  | 1392641 | 79625 | SH |  | SOLE |  | 74700 | 0 | 4925 |
| SYNDAX PHARMACEUTICALS | COM | 87164F105 |  | 1285813 | 61200 | SH |  | SOLE |  | 58150 | 0 | 3050 |
| TARSUS PHARMACEUTICAL | COM | 87650L103 |  | 1206911 | 14740 | SH |  | SOLE |  | 13700 | 0 | 1040 |
| TECTONIC THERAPEUTICS | COM | 878972108 |  | 881439 | 42255 | SH |  | SOLE |  | 40700 | 0 | 1555 |
| TEMPUS AI INC | CL A | 88023B103 |  | 265725 | 4500 | SH |  | SOLE |  | 3880 | 0 | 620 |
| THERMO FISHER SCIENTIFIC | COM | 883556102 |  | 2259855 | 3900 | SH |  | SOLE |  | 3900 | 0 | 0 |
| TREVI THERAPEUTIC INC | COM | 89532M101 |  | 1054873 | 84255 | SH |  | SOLE |  | 79950 | 0 | 4305 |
| UNIQURE N.V. | SHS | N90064101 |  | 731899 | 30585 | SH |  | SOLE |  | 29100 | 0 | 1485 |
| UNITED THERAPEUTICS | COM | 91307C102 |  | 839532 | 1723 | SH |  | SOLE |  | 1475 | 0 | 248 |
| UNITEDHEALTH GRP INC | COM | 91324P102 |  | 4487845 | 13595 | SH |  | SOLE |  | 13595 | 0 | 0 |
| VENTYX BIOSCIENCES | COM | 92332V107 |  | 875413 | 96945 | SH |  | SOLE |  | 94000 | 0 | 2945 |
| VERA THERAPEUTICS | CL A | 92337R101 |  | 1866490 | 36858 | SH |  | SOLE |  | 35290 | 0 | 1568 |
| VERTEX PHARMA | COM | 92532F100 |  | 3629147 | 8005 | SH |  | SOLE |  | 7095 | 0 | 910 |

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