# EDGAR Filing Document

**Accession Number:** 0001505497
**File Stem:** 0001493152-26-019129
**Filing Date:** 2026-4
**Character Count:** 34758
**Document Hash:** 789230b8bff4d349523d621fb3363416
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001493152-26-019129.hdr.sgml**: 20260427

**ACCESSION NUMBER**: 0001493152-26-019129

**CONFORMED SUBMISSION TYPE**: POS AM

**PUBLIC DOCUMENT COUNT**: 5

**FILED AS OF DATE**: 20260427

**DATE AS OF CHANGE**: 20260427

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** BioRestorative Therapies, Inc.
- **CENTRAL INDEX KEY:** 0001505497
- **STANDARD INDUSTRIAL CLASSIFICATION:** SERVICES-MISC HEALTH & ALLIED SERVICES, NEC [8090]
- **ORGANIZATION NAME:** 08 Industrial Applications and Services
- **EIN:** 301341024
- **STATE OF INCORPORATION:** NV
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** POS AM
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-293322
- **FILM NUMBER:** 26900858

**BUSINESS ADDRESS:**
- **STREET 1:** 40 MARCUS DRIVE
- **CITY:** MELVILLE
- **STATE:** NY
- **ZIP:** 11747
- **BUSINESS PHONE:** (631) 760-8100

**MAIL ADDRESS:**
- **STREET 1:** 40 MARCUS DRIVE
- **CITY:** MELVILLE
- **STATE:** NY
- **ZIP:** 11747

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Stem Cell Assurance, Inc.
- **DATE OF NAME CHANGE:** 20101110

**As filed with the Securities and Exchange Commission on April 27, 2026.**

Registration No. 333-293322

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**AMENDMENT NO. 1**

**TO** 

**POST-EFFECTIVE AMENDMENT NO. 1**

**TO**

**FORM S-1/A**

**REGISTRATION STATEMENT**

**UNDER**

**THE SECURITIES ACT OF 1933**

**BIORESTORATIVE THERAPIES, INC.**

(Exact name of registrant as specified in its charter)

---

| | | |
|:---|:---|:---|
| **Nevada** | **8099** | **30-1341024** |
| (State or other jurisdiction of | (Primary Standard Industrial | (I.R.S. Employer |
| incorporation or organization) | Classification Code Number) | Identification Number) |

---

**40 Marcus Drive, Suite One**

**Melville, New York 11747**

**(631) 760-8100**

(Address, including zip code, and telephone number, including area code, of registrant's principal executive offices)

**Lance Alstodt, President and Chief Executive Officer**

**BioRestorative Therapies, Inc.**

**40 Marcus Drive, Suite One**

**Melville, New York 11747**

**(631) 760-8100**

(Name, address, including zip code, and telephone number, including area code, of agent for service)

*With copies to:*

---

| | |
|:---|:---|
| **Fred Skolnik, Esq.**<br> **Certilman Balin Adler & Hyman, LLP**<br> **90 Merrick Avenue**<br> **East Meadow, New York 11554**<br> **(516) 296-7048** | **Matthew Bernstein, Esq.** <br> **Justin Grossman, Esq.**<br> **Ellenoff Grossman & Schole LLP**<br> **1345 Avenue of the Americas**<br> **New York, New York 10105**<br> **(212) 370-1300** |

---

Approximate date of commencement of proposed sale to the public: **As soon as practicable after the effective date of this registration statement**

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, check the following box. ☒

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐

If this Form is a post-effective amendment filed pursuant to Rule 462(d) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | |
|:---|:---|
| Large accelerated filer ☐ | Accelerated filer ☐ |
| Non-accelerated filer ☒ | Smaller reporting company ☒ |
|  | Emerging growth company ☐ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

**The registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the registrant shall file a further amendment which specifically states that this registration statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933, as amended, or until this registration statement shall become effective on such date as the Securities and Exchange Commission, acting pursuant to said Section 8(a), may determine.**

**EXPLANATORY NOTE**

This Amendment No. 1 (this "Amendment") to the Post-Effective Amendment No. 1 to Registration Statement on Form S-1 of BioRestorative Therapies, Inc. ([File No. 333-293322](https://www.sec.gov/Archives/edgar/data/1505497/000149315226018143/formposam.htm)) (the "Registration Statement") is being filed as an exhibit-only filing to file a revised opinion of counsel, filed herewith as Exhibit 5. Accordingly, this Amendment consists only of the facing page, this explanatory note, Item 16 of Part II of the Registration Statement, the signature page to the Registration Statement, and the revised opinion of counsel, filed herewith as Exhibit 5. The prospectus and the balance of Part II of the Registration Statement are unchanged and have been omitted.

**Item 16. Exhibits.**

---

| | |
|:---|:---|
| **Exhibit Number** | <br> **Exhibit Description** |
| 3.1 | [Amended and Restated Articles of Incorporation, incorporated by reference to the registrant's Current Report on Form 8-K for an event dated December 29, 2022, wherein such document is identified as Exhibit 3.3](https://www.sec.gov/Archives/edgar/data/1505497/000102177123000002/ex3_3.htm) |
| 3.2 | [Certificate of Designations of Series B Preferred Stock, incorporated by reference to the registrant's Current Report on Form 8-K for an event dated December 29, 2022, wherein such document is identified as Exhibit 3.4](https://www.sec.gov/Archives/edgar/data/1505497/000102177123000002/ex3_4.htm) |
| 3.3 | [Bylaws, incorporated by reference to the registrant's Current Report on Form 8-K for an event dated December 29, 2022, wherein such document is identified as Exhibit 3.5](https://www.sec.gov/Archives/edgar/data/1505497/000102177123000002/ex3_5.htm) |
| 4.1 | [Description of Securities Registered Under Section 12 of the Securities Exchange Act of 1934, incorporated by reference to the registrant's Amendment No. 2 to Annual Report on Form 10-K/A for the year ended December 31, 2023, wherein such document is identified as Exhibit 4.1](https://www.sec.gov/Archives/edgar/data/1505497/000149315224043839/ex4-1.htm) |
| 5.1 | [Opinion of Certilman Balin Adler & Hyman, LLP\*](ex5-1.htm) |
| 10.1 | [License Agreement, dated as of January 27, 2012, between Regenerative Sciences, LLC and BioRestorative Therapies, Inc. ("License Agreement"), incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2011, wherein such document is identified as Exhibit 10.44](https://www.sec.gov/Archives/edgar/data/1505497/000114420412021914/v308966_ex10-44.htm) |
| 10.2 | [Amendment to License Agreement, dated March 21, 2012, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2011, wherein such document is identified as Exhibit 10.45](https://www.sec.gov/Archives/edgar/data/1505497/000114420412021914/v308966_ex10-45.htm) |
| 10.3 | [Amendment to License Agreement, dated November 30, 2015, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2015, wherein such document is identified as Exhibit 10.20](https://www.sec.gov/Archives/edgar/data/1505497/000114420416091575/v434828_ex10-20.htm) |
| 10.4 | [Letter agreement, dated November 21, 2022, by and among BioRestorative Therapies, Inc., Regenerative Sciences, LLC and Regenexx, LLC with regard to License Agreement, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2022, wherein such document is identified as Exhibit 10.4](https://www.sec.gov/Archives/edgar/data/1505497/000149315223008960/ex10-4.htm) |
| 10.5 | [Lease, dated as of August 25, 2014, between BioRestorative Therapies, Inc. and 50 Republic Road, LLC, incorporated by reference to the registrant's Current Report on Form 8-K for an event dated August 25, 2014, wherein such document is identified as Exhibit 99.1](https://www.sec.gov/Archives/edgar/data/1505497/000102177114000054/ex99_1.htm) |
| 10.6 | [Lease Amendment, dated as of June 4, 2019, between 50 Republic Road, LLC and BioRestorative Therapies, Inc., incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2019, wherein such document is identified as Exhibit 10.37](https://www.sec.gov/Archives/edgar/data/1505497/000149315221006285/ex10-37.htm) |
| 10.7 | [BioRestorative Therapies, Inc. 2021 Stock Incentive Plan, as amended, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2025, wherein such document is identified as Exhibit 10.7](https://www.sec.gov/Archives/edgar/data/1505497/000149315224012056/ex10-7.htm) |
| 10.8 | [Executive Employment Agreement, dated as of March 18, 2021, by and between BioRestorative Therapies, Inc. and Lance Alstodt, incorporated by reference to the registrant's Current Report on Form 8-K for an event dated March 18, 2021, wherein such document is identified as Exhibit 99.2](https://www.sec.gov/Archives/edgar/data/1505497/000102177121000020/ex99_2.htm) |
| 10.9 | [Executive Employment Agreement, dated as of March 18, 2021, by and between BioRestorative Therapies, Inc. and Francisco Silva, incorporated by reference to the registrant's Current Report on Form 8-K for an event dated March 18, 2021, wherein such document is identified as Exhibit 99.3](https://www.sec.gov/Archives/edgar/data/1505497/000102177121000020/ex99_3.htm) |

---

10.10 [Non-Qualified Stock Option Award Agreement, dated as of March 18, 2021, between BioRestorative Therapies, Inc. and Lance Alstodt, incorporated by reference to the registrant's Current Report on Form 8-K for an event dated March 18, 2021, wherein such document is identified as Exhibit 99.4](https://www.sec.gov/Archives/edgar/data/1505497/000102177121000020/ex99_4.htm)

10.11 [Non-Qualified Stock Option Award Agreement, dated as of March 18, 2021, between BioRestorative Therapies, Inc. and Francisco Silva, incorporated by reference to the registrant's Current Report on Form 8-K for an event dated March 18, 2021, wherein such document is identified as Exhibit 99.5](https://www.sec.gov/Archives/edgar/data/1505497/000102177121000020/ex99_5.htm)

10.12 [Non-Qualified Stock Option Award Agreement, dated as of November 4, 2021, between BioRestorative Therapies, Inc. and Lance Alstodt, incorporated by reference to the registrant's Current Report on Form 8-K for an event dated November 4, 2021, wherein such document is identified as Exhibit 99.1](https://www.sec.gov/Archives/edgar/data/1505497/000102177121000087/ex99_1.htm)

10.13 [Non-Qualified Stock Option Award Agreement, dated as of November 4, 2021, between BioRestorative Therapies, Inc. and Francisco Silva, incorporated by reference to the registrant's Current Report on Form 8-K for an event dated November 4, wherein such document is identified as Exhibit 99.2](https://www.sec.gov/Archives/edgar/data/1505497/000102177121000087/ex99_2.htm)

10.14 [Non-Qualified Stock Option Award Agreement, dated as of November 4, 2021, between BioRestorative Therapies, Inc. and Nickolay Kukekov, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2021, wherein such document is identified as Exhibit 10.15](https://www.sec.gov/Archives/edgar/data/1505497/000149315222008184/ex10-15.htm)

10.15 [Non-Qualified Stock Option Award Agreement, dated as of November 4, 2021, between BioRestorative Therapies, Inc. and Patrick F. Williams, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2021, wherein such document is identified as Exhibit 10.16](https://www.sec.gov/Archives/edgar/data/1505497/000149315222008184/ex10-16.htm)

10.16 [Non-Qualified Stock Option Award Agreement, dated as of November 4, 2021, between BioRestorative Therapies, Inc. and David Rosa, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2021, wherein such document is identified as Exhibit 10.17](https://www.sec.gov/Archives/edgar/data/1505497/000149315222008184/ex10-17.htm)

10.17 [Amendment No. 1 to Non-Qualified Stock Option Award Agreement, dated as of November 4, 2021, between BioRestorative Therapies, Inc. and Lance Alstodt, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2021, wherein such document is identified as Exhibit 10.18](https://www.sec.gov/Archives/edgar/data/1505497/000149315222008184/ex10-18.htm)

10.18 [Amendment No. 1 to Non-Qualified Stock Option Award Agreement, dated as of November 4, 2021, between BioRestorative Therapies, Inc. and Francisco Silva, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2021, wherein such document is identified as Exhibit 10.19](https://www.sec.gov/Archives/edgar/data/1505497/000149315222008184/ex10-19.htm)

10.19 [Common Stock Purchase Warrant, dated November 9, 2021, issued by BioRestorative Therapies, Inc. pursuant to public offering, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2021, wherein such document is identified as Exhibit 10.20](https://www.sec.gov/Archives/edgar/data/1505497/000149315222008184/ex10-20.htm)

10.20 [Common Stock Purchase Warrant, dated November 9, 2021, issued by BioRestorative Therapies, Inc. to Auctus Fund, LLC, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2021, wherein such document is identified as Exhibit 10.21](https://www.sec.gov/Archives/edgar/data/1505497/000149315222008184/ex10-21.htm)

10.21 [Amendment No. 2 to Non-Qualified Stock Option Award Agreement, dated as of December 10, 2021, between BioRestorative Therapies, Inc. and Lance Alstodt, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2021, wherein such document is identified as Exhibit 10.22](https://www.sec.gov/Archives/edgar/data/1505497/000149315222008184/ex10-22.htm)

10.22 [Amendment No. 2 to Non-Qualified Stock Option Award Agreement, dated as of December 10, 2021, between BioRestorative Therapies, Inc. and Francisco Silva, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2021, wherein such document is identified as Exhibit 10.23](https://www.sec.gov/Archives/edgar/data/1505497/000149315222008184/ex10-23.htm)

10.23 [Amendment No. 1 to Non-Qualified Stock Option Award Agreement, dated as of December 10, 2021, between BioRestorative Therapies, Inc. and Nickolay Kukekov, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2021, wherein such document is identified as Exhibit 10.24](https://www.sec.gov/Archives/edgar/data/1505497/000149315222008184/ex10-24.htm)

10.24 [Amendment No. 1 to Non-Qualified Stock Option Award Agreement, dated as of December 10, 2021, between BioRestorative Therapies, Inc. and Patrick F. Williams, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2021, wherein such document is identified as Exhibit 10.25](https://www.sec.gov/Archives/edgar/data/1505497/000149315222008184/ex10-25.htm)

10.25 [Amendment No. 1 to Non-Qualified Stock Option Award Agreement, dated as of December 10, 2021, between BioRestorative Therapies, Inc. and David Rosa, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2021, wherein such document is identified as Exhibit 10.26](https://www.sec.gov/Archives/edgar/data/1505497/000149315222008184/ex10-26.htm)

10.26 [Incentive Stock Option Award Agreement, dated as of February 17, 2023, between BioRestorative Therapies, Inc. and Lance Alstodt, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2022, wherein such document is identified as Exhibit 10.28](https://www.sec.gov/Archives/edgar/data/1505497/000149315223008960/ex10-28.htm)

10.27 [Incentive Stock Option Award Agreement, dated as of February 17, 2023, between BioRestorative Therapies, Inc. and Francisco Silva, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2022, wherein such document is identified as Exhibit 10.29](https://www.sec.gov/Archives/edgar/data/1505497/000149315223008960/ex10-29.htm)

10.28 [Incentive Stock Option Award Agreement, dated as of February 17, 2023, between BioRestorative Therapies, Inc. and Robert Kristal, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2022, wherein such document is identified as Exhibit 10.30](https://www.sec.gov/Archives/edgar/data/1505497/000149315223008960/ex10-30.htm)

10.29 [Non-Qualified Stock Option Award Agreement, dated as of February 17, 2023, between BioRestorative Therapies, Inc. and Nickolay Kukekov, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2022, wherein such document is identified as Exhibit 10.32](https://www.sec.gov/Archives/edgar/data/1505497/000149315223008960/ex10-32.htm)

10.30 [Non-Qualified Stock Option Award Agreement, dated as of February 17, 2023, between BioRestorative Therapies, Inc. and Patrick F. Williams, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2022, wherein such document is identified as Exhibit 10.33](https://www.sec.gov/Archives/edgar/data/1505497/000149315223008960/ex10-33.htm)

10.31 [Non-Qualified Stock Option Award Agreement, dated as of February 17, 2023, between BioRestorative Therapies, Inc. and David Rosa, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2022, wherein such document is identified as Exhibit 10.34](https://www.sec.gov/Archives/edgar/data/1505497/000149315223008960/ex10-34.htm)

10.32 [Form of Warrant, dated February 8, 2024 (issued to warrantholders other than Auctus Fund, LLC), incorporated by reference to the registrant's Current Report on Form 8-K for an event dated February 6, 2024, wherein such document is identified as Exhibit 10.3](https://www.sec.gov/Archives/edgar/data/1505497/000102177124000033/ex10_3.htm)

10.33 [Warrant, dated February 8, 2024 (issued to Auctus Fund, LLC), incorporated by reference to the registrant's Current Report on Form 8-K for an event dated February 6, 2024, wherein such document is identified as Exhibit 10.4](https://www.sec.gov/Archives/edgar/data/1505497/000102177124000033/ex10_4.htm)

10.34 [Incentive Stock Option Award Agreement, dated as of February 13, 2024, between BioRestorative Therapies, Inc. and Lance Alstodt, incorporated by reference to the registrant's Annual Report on Form 10-K/A (Amendment No. 1) for the year ended December 31, 2023, wherein such document is identified as Exhibit 10.36](https://www.sec.gov/Archives/edgar/data/1505497/000149315224012056/ex10-36.htm)

10.35 [Incentive Stock Option Award Agreement, dated as of February 13, 2024, between BioRestorative Therapies, Inc. and Francisco Silva, incorporated by reference to the registrant's Annual Report on Form 10-K/A (Amendment No. 1) for the year ended December 31, 2023, wherein such document is identified as Exhibit 10.37](https://www.sec.gov/Archives/edgar/data/1505497/000149315224012056/ex10-37.htm)

10.36 [Incentive Stock Option Award Agreement, dated as of February 13, 2024, between BioRestorative Therapies, Inc. and Robert Kristal, incorporated by reference to the registrant's Annual Report on Form 10-K/A (Amendment No. 1) for the year ended December 31, 2023, wherein such document is identified as Exhibit 10.38](https://www.sec.gov/Archives/edgar/data/1505497/000149315224012056/ex10-38.htm)

10.37 [Non-Qualified Stock Option Award Agreement, dated as of February 13, 2024, between BioRestorative Therapies, Inc. and Nickolay Kukekov, incorporated by reference to the registrant's Annual Report on Form 10-K/A (Amendment No. 1) for the year ended December 31, 2023, wherein such document is identified as Exhibit 10.40](https://www.sec.gov/Archives/edgar/data/1505497/000149315224012056/ex10-40.htm)

10.38 [Non-Qualified Stock Option Award Agreement, dated as of February 13, 2024, between BioRestorative Therapies, Inc. and Patrick F. Williams, incorporated by reference to the registrant's Annual Report on Form 10-K/A (Amendment No. 1) for the year ended December 31, 2023, wherein such document is identified as Exhibit 10.41](https://www.sec.gov/Archives/edgar/data/1505497/000149315224012056/ex10-41.htm)

10.39 [Non-Qualified Stock Option Award Agreement, dated as of February 13, 2024, between BioRestorative Therapies, Inc. and David Rosa, incorporated by reference to the registrant's Annual Report on Form 10-K/A (Amendment No. 1) for the year ended December 31, 2023, wherein such document is identified as Exhibit 10.42](https://www.sec.gov/Archives/edgar/data/1505497/000149315224012056/ex10-42.htm)

10.40 [At the Market Offering Agreement, dated as of November 6, 2024, by and between BioRestorative Therapies, Inc. and Rodman & Renshaw, LLC, incorporated by reference to the registrant's Current Report on Form 8-K for an event dated November 1, 2024, wherein such document is identified as Exhibit 1.1](https://www.sec.gov/Archives/edgar/data/1505497/000102177124000188/ex1_1.htm)

10.41 [Incentive Stock Option Award Agreement, dated as of February 14, 2025, between BioRestorative Therapies, Inc. and Lance Alstodt, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2024, wherein such document is identified as Exhibit 10.40](https://www.sec.gov/Archives/edgar/data/1505497/000164117225001011/ex10-40.htm)

10.42 [Incentive Stock Option Award Agreement, dated as of February 14, 2025, between BioRestorative Therapies, Inc. and Francisco Silva, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2024, wherein such document is identified as Exhibit 10.41](https://www.sec.gov/Archives/edgar/data/1505497/000164117225001011/ex10-41.htm)

10.43 [Incentive Stock Option Award Agreement, dated as of February 14, 2025, between BioRestorative Therapies, Inc. and Robert Kristal, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2024, wherein such document is identified as Exhibit 10.42](https://www.sec.gov/Archives/edgar/data/1505497/000164117225001011/ex10-42.htm)

10.44 [Non-Qualified Stock Option Award Agreement, dated as of February 14, 2025, between BioRestorative Therapies, Inc. and Nickolay Kukekov, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2024, wherein such document is identified as Exhibit 10.43](https://www.sec.gov/Archives/edgar/data/1505497/000164117225001011/ex10-43.htm)

10.45 [Non-Qualified Stock Option Award Agreement, dated as of February 14, 2025 between BioRestorative Therapies, Inc. and Patrick F. Williams, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2024, wherein such document is identified as Exhibit 10.44](https://www.sec.gov/Archives/edgar/data/1505497/000164117225001011/ex10-44.htm)

10.46 [Non-Qualified Stock Option Award Agreement, dated as of February 14, 2025, between BioRestorative Therapies, Inc. and David Rosa, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2024, wherein such document is identified as Exhibit 10.45](https://www.sec.gov/Archives/edgar/data/1505497/000164117225001011/ex10-45.htm)

10.47 [Form of Common Stock Purchase Warrant, dated October 8, 2025, incorporated by reference to the registrant's Current Report on Form 8-K for an event dated October 6, 2025, wherein such document is identified as Exhibit 4.1](https://www.sec.gov/Archives/edgar/data/1505497/000149315225017446/ex4-1.htm)

---

| | |
|:---|:---|
| 10.48 | [Amendment, dated October 15, 2025, to Common Stock Purchase Warrant, dated October 8, 2025, issued to Auctus Fund, LLC, incorporated by reference to the registrant's Registration Statement on Form S-1, File No. 333-291623, filed with the SEC on November 18, 2025, wherein such document is identified as Exhibit 10.49](https://www.sec.gov/Archives/edgar/data/1505497/000149315225024081/ex10-49.htm) |
| 10.49 | [Form of Common Stock Warrant, incorporated by reference to the registrant's Registration Statement on Form S-1/A, File No. 333-293322, filed with the SEC on February 10, 2026, wherein such document is identified as Exhibit 4.2](https://www.sec.gov/Archives/edgar/data/1505497/000149315226005827/ex4-2.htm) |
| 10.50 | [Form of Placement Agent Warrant, incorporated by reference to the registrant's Registration Statement on Form S-1/A, File No. 333-293322, filed with the SEC on February 10, 2026, wherein such document is identified as Exhibit 4.4](https://www.sec.gov/Archives/edgar/data/1505497/000149315226005827/ex4-4.htm) |
| 10.51 | [Form of Securities Purchase Agreement, incorporated by reference to the registrant's Registration Statement on Form S-1/A, File No. 333-293322, filed with the SEC on February 10, 2026, wherein such document is identified as Exhibit 10.50](https://www.sec.gov/Archives/edgar/data/1505497/000149315226005827/ex10-50.htm) |
| 10.52 | [Form of Placement Agency Agreement, dated February 11, 2026, between BioRestorative Therapies, Inc. and Rodman & Renshaw LLC, incorporated by reference to the registrant's Current Report on Form 8-K for an event dated February 17, 2026, wherein such document is identified as Exhibit 10.2](https://www.sec.gov/Archives/edgar/data/1505497/000149315226006837/ex10-2.htm) |
| 21 | [Subsidiaries, incorporated by reference to the registrant's Annual Report on Form 10-K for the year ended December 31, 2018, wherein such document is identified as Exhibit 21](https://www.sec.gov/Archives/edgar/data/1505497/000149315219004292/ex21.htm) |
| 23.1 | [Consent of Marcum LLP\*\*](https://www.sec.gov/Archives/edgar/data/1505497/000149315226018143/ex23-1.htm) |
| 23.2 | [Consent of CBIZ CPAs P.C.\*\*](https://www.sec.gov/Archives/edgar/data/1505497/000149315226018143/ex23-2.htm) |
| 23.3 | [Consent of Certilman Balin Adler & Hyman, LLP (included in the opinion of Certilman Balin Adler & Hyman, LLP filed as Exhibit 5)](ex5-1.htm) |
| 24 | [Power of Attorney (included on signature page of the Registration Statement)](#N_001) |
| 101.INS | Inline XBRL Instance Document \*\* |
| 101.SCH | Inline XBRL Schema Document \*\* |
| 101.CAL | Inline XBRL Calculation Linkbase Document\*\* |
| 101.DEF | Inline XBRL Definition Linkbase Document\*\* |
| 101.LAB | Inline XBRL Label Linkbase Documents\*\* |
| 101.PRE | Inline XBRL Presentation Linkbase Document\*\* |
| 104 | Cover Page Interactive Data File (embedded within the Inline XBRL document) |
| 107 | [Filing Fee Table\*\*](https://www.sec.gov/Archives/edgar/data/1505497/000149315226018143/ex107.htm) |

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\*Filed herewith.

\*\*Previously filed.

**SIGNATURES**

Pursuant to the requirements of the Securities Act of 1933, the registrant has duly caused this Amendment No. 1 to Post-Effective Amendment No. 1 to the Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in Melville, New York, on April 27, 2026.

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| | |
|:---|:---|
| **BIORESTORATIVE THERAPIES, INC.** | **BIORESTORATIVE THERAPIES, INC.** |
| By: | */s/ Lance Alstodt* |
|  | Lance Alstodt |
|  | President, Chief Executive Officer and Chairman of the Board |

---

Pursuant to the requirements of the Securities Act of 1933, this Amendment No. 1 to Post-Effective Amendment No. 1 to the Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

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| | | |
|:---|:---|:---|
| **Signature** | **Title** | **Date** |
| */s/ Lance Alstodt* | President, Chief Executive Officer and Chairman of the Board (Principal Executive Officer) | April 27, 2026 |
| Lance Alstodt |  |  |
| \* | Vice President, Research and Development, Secretary and Director | April 27, 2026 |
| Francisco Silva |  |  |
| \* | Chief Financial Officer (Principal Financial Officer and Principal Accounting Officer) | April 27, 2026 |
| Robert E. Kristal |  |  |
| \* | Director | April 27, 2026 |
| Nickolay Kukekov |  |  |
| \* | Director | April 27, 2026 |
| Patrick F. Williams |  |  |
| \* | Director | April 27, 2026 |
| David Rosa |  |  |

---

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| | |
|:---|:---|
| \*By: | */s/ Lance Alstodt* |
|  | Lance Alstodt |
|  | Attorney-In-Fact |

---

## Exhibit 5.1

**Exhibit 5.1**

![](ex5-1_001.jpg)

**FRED S. SKOLNIK**

PARTNER

DIRECT DIAL 516.296.7048

fskolnik@certilmanbalin.com

April 27, 2026

BioRestorative Therapies, Inc.

40 Marcus Drive

Melville, New York 11747

Re: Registration Statement on Form S-1

Ladies and Gentlemen:

We have acted as counsel to BioRestorative Therapies, Inc., a Nevada corporation (the "Company"), in connection with the Registration Statement on Form S-1 (Registration No. 333-293322), as amended (the "Registration Statement"), filed by the Company with the Securities and Exchange Commission (the "Commission") under the Securities Act of 1933, as amended (the "Act"), relating to the offer and sale by the Company of up to 14,285,715 units (the "Units"), each Unit consisting of one share of common stock, par value $0.0001 per share (the "Common Stock") (the "Shares"), or one pre-funded warrant to purchase one share of Common Stock (the "Pre-Funded Warrant") and one warrant to purchase one share of Common Stock (the "Warrant"). The shares of Common Stock underlying the Pre-Funded Warrants and the Warrants are collectively referred to herein as the "Warrant Shares".

In connection with this opinion, we have examined the following documents: (i) the Amended and Restated Articles of Incorporation and the By-Laws of the Company, each as amended to date, (ii) the Registration Statement, (iii) the form of Pre-Funded Warrant, (iv) the form of Warrant, and (iv) minutes of meetings and unanimous written consents of the Board of Directors of the Company and committees thereof. We have also examined such other instruments and documents as we deemed relevant under the circumstance.

For purposes of this opinion, we have assumed (i) the authenticity of all documents submitted to us as original, (ii) the conformity to the originals of all documents submitted as certified, photostatic or facsimile copies and the authenticity of the originals, (iii) the legal capacity of natural persons, (iv) the due authorization, execution and delivery of all documents by all parties and the validity and binding effect thereof and (v) the conformity to the proceedings of the Board of Directors and committees thereof of all minutes of such proceedings. We have also assumed that the corporate records furnished to us by the Company include all corporate proceedings taken by the Company to date.

![](ex5-1_002.jpg)

Based upon the foregoing and subject to the limitations, qualifications, exceptions and assumptions set forth herein, it is our opinion that (i) the Shares have been duly authorized and, when issued and delivered by the Company against payment therefor as described in the Registration Statement, will be duly and validly issued, fully paid and non-assessable shares of Common Stock; (ii) the Pre-Funded Warrants have been duly authorized and, when issued and delivered by the Company against payment therefor as described in the Registration Statement, will be valid and binding obligations of the Company; (iii) the Warrants have been duly authorized and, when issued and delivered by the Company against payment therefor as described in the Registration Statement, will be valid and binding obligations of the Company and (iv) the Warrant Shares have been duly authorized and, when issued and delivered by the Company against payment therefor in accordance with the terms of the Pre-Funded Warrants and the Warrants, will be duly and validly issued, fully paid and non-assessable shares of Common Stock.

We hereby consent to the use of our opinion as herein set forth as an exhibit to the Registration Statement and to the use of our name therein and in the related prospectus under the caption "Legal Matters". In giving such consent, we do not hereby admit that we are in the category of persons whose consent is required under Section 7 of the Act or the rules and regulations of the Commission thereunder.

The opinion expressed herein is limited to the Nevada Revised Statutes, as currently in effect, and we express no opinion as to the effect of the laws of any other jurisdiction.

This opinion is as of the date hereof, and we do not undertake, and hereby disclaim, any obligation to advise you of any changes in any of the matters set forth herein.

We are rendering this opinion only as to the matters expressly set forth herein, and no opinion should be inferred as to any other matters.

This opinion is for your exclusive use only and is to be utilized and relied upon only in connection with the matters expressly set forth herein.

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| | |
|:---|:---|
| Very truly yours, | Very truly yours, |
| CERTILMAN BALIN ADLER & HYMAN, LLP | CERTILMAN BALIN ADLER & HYMAN, LLP |
| By: | */s/ Fred Skolnik* |
|  | Fred Skolnik, a Member of the Firm |

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![](ex5-1_003.jpg)