# EDGAR Filing Document

**Accession Number:** 0001100663
**File Stem:** 0002071691-26-012466
**Filing Date:** 2026-5
**Character Count:** 93481
**Document Hash:** a7d83ba73d726a01ebe1650c926bf14d
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0002071691-26-012466.hdr.sgml**: 20260528

**ACCESSION NUMBER**: 0002071691-26-012466

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20260331

**FILED AS OF DATE**: 20260528

**DATE AS OF CHANGE**: 20260528

**PERIOD START**: 20260331

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** iSHARES TRUST
- **CENTRAL INDEX KEY:** 0001100663

**ORGANIZATION NAME:**
- **EIN:** 943351276
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-09729
- **FILM NUMBER:** 261029713

**BUSINESS ADDRESS:**
- **STREET 1:** 400 HOWARD STREET
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94105
- **BUSINESS PHONE:** (415) 670-2000

**MAIL ADDRESS:**
- **STREET 1:** 400 HOWARD STREET
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94105

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ISHARES TRUST
- **DATE OF NAME CHANGE:** 19991213

## Series and Classes Contracts Data

### iShares Biotechnology ETF (Series ID: S000004350)

| Class ID   | Class Name                | Ticker Symbol   |
|:---|:---|:---|
| C000012080 | iShares Biotechnology ETF | IBB             |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** iShares Trust

- **b. Investment Company Act file number:** 811-09729

- **c. CIK number of Registrant:** 0001100663

- **d. LEI of Registrant:** 5493000860OXIC4B5K91

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 400 Howard Street

  - **City:** San Francisco

  - **State:** CA

  - **Foreign country:** US

  - **Zip / Postal Code:** 94105

  - **Telephone number:** 800-474-2737

**Item A.2. Information about the Series.**

- **a. Name of Series:** iShares Biotechnology ETF

- **b. EDGAR series identifier (if any):** S000004350

- **c. LEI of Series:** 549300S7IVD88MPK0066

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2026-03-31

- **b. Date as of which information is reported:** 2026-03-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $8912517349.93

**Total Liabilities:** $789856837.25

**Net Assets:** $8122660512.68

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000012080 | 2.14%                | 1.69%                | -3.61%               |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $135491944.38            | $41697611.83                               |
| Month 2  | $195928720.69            | $-52043054.71                              |
| Month 3  | $133416076.77            | $-457274003.76                             |

**Designated Index Information**

- **Index Name:** N/A

- **Index Identifier:** N/A

### Schedule of Portfolio Investments

| Name                                           | Title                                                 | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| MannKind Corp.                                 | MannKind Corp.                                        | CUSIP: 56400P706<br>LEI: 213800GFBCNY1ZFST722 | Long             | EC               | CORP              | US        |   2199381 | NS      | $5388483.45   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Neurogene, Inc.                                | Neurogene, Inc.                                       | CUSIP: 64135M105<br>LEI: 529900A7VIY892SZVW73 | Long             | EC               | CORP              | US        |     94694 | NS      | $1909031.04   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Apogee Therapeutics, Inc.                      | Apogee Therapeutics, Inc.                             | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    353520 | NS      | $29755778.40  | 0.37%             |  |  |  | No            |                  1 | On Loan: —       |
| Enliven Therapeutics, Inc.                     | Enliven Therapeutics, Inc.                            | CUSIP: 29337E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    322556 | NS      | $12644195.20  | 0.16%             |  |  |  | No            |                  1 | On Loan: —       |
| Bicycle Therapeutics plc                       | Bicycle Therapeutics plc                              | CUSIP: 088786108<br>LEI: 213800XKUI6R7GKC3E43 | Long             | EC               | CORP              | GB        |    244101 | NS      | $1132628.64   | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                            | Russell 2000 E-Mini Index                             | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |        33 | NC      | $56477.09     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Cargo Therapeutics, Inc.                       | Cargo Therapeutics, Inc., CVR                         | CUSIP: 141CVR019<br>LEI: N/A                  | Long             |  | CORP              | US        |    198104 | NS      | $1.98         | 0.00%             |  |  |  | No            |                  3 | On Loan: —       |
| Ionis Pharmaceuticals, Inc.                    | Ionis Pharmaceuticals, Inc.                           | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |   1205549 | NS      | $90524674.41  | 1.11%             |  |  |  | No            |                  1 | On Loan: No      |
| United Therapeutics Corp.                      | United Therapeutics Corp.                             | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |    315509 | NS      | $187090526.82 | 2.30%             |  |  |  | No            |                  1 | On Loan: —       |
| Solid Biosciences, Inc.                        | Solid Biosciences, Inc.                               | CUSIP: 83422E204<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    446552 | NS      | $3215174.40   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| uniQure NV                                     | uniQure NV                                            | CUSIP: N/A<br>LEI: 724500RPCTZLFYJZ3S98       | Long             | EC               | CORP              | NL        |    413699 | NS      | $6763978.65   | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| ORIC Pharmaceuticals, Inc.                     | ORIC Pharmaceuticals, Inc.                            | CUSIP: 68622P109<br>LEI: 54930033FJRNEYBW0L25 | Long             | EC               | CORP              | US        |    424422 | NS      | $5377426.74   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Tango Therapeutics, Inc.                       | Tango Therapeutics, Inc.                              | CUSIP: 87583X109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    687885 | NS      | $14390554.20  | 0.18%             |  |  |  | No            |                  1 | On Loan: —       |
| Madrigal Pharmaceuticals, Inc.                 | Madrigal Pharmaceuticals, Inc.                        | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |    155341 | NS      | $81316353.27  | 1.00%             |  |  |  | No            |                  1 | On Loan: No      |
| 4D Molecular Therapeutics, Inc.                | 4D Molecular Therapeutics, Inc.                       | CUSIP: 35104E100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    338744 | NS      | $3153706.64   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Savara, Inc.                                   | Savara, Inc.                                          | CUSIP: 805111101<br>LEI: 5493002JO0WM3YMJXG33 | Long             | EC               | CORP              | US        |    775563 | NS      | $4234573.98   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Stoke Therapeutics, Inc.                       | Stoke Therapeutics, Inc.                              | CUSIP: 86150R107<br>LEI: 549300RD25SS2DIJHJ67 | Long             | EC               | CORP              | US        |    331288 | NS      | $10786737.28  | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| BioMarin Pharmaceutical, Inc.                  | BioMarin Pharmaceutical, Inc.                         | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |   1412330 | NS      | $79782521.70  | 0.98%             |  |  |  | No            |                  1 | On Loan: No      |
| Lexeo Therapeutics, Inc.                       | Lexeo Therapeutics, Inc.                              | CUSIP: 52886X107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    457447 | NS      | $2625745.78   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Kymera Therapeutics, Inc.                      | Kymera Therapeutics, Inc.                             | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    521385 | NS      | $43426156.65  | 0.53%             |  |  |  | No            |                  1 | On Loan: —       |
| Alumis, Inc.                                   | Alumis, Inc.                                          | CUSIP: 022307102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    530358 | NS      | $11683786.74  | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Quantum-Si, Inc.                               | Quantum-Si, Inc.                                      | CUSIP: 74765K105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1223534 | NS      | $947015.32    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Fusion Pharmaceuticals, Inc.                   | Fusion Pharmaceuticals, Inc., CVR                     | CUSIP: 361CVR012<br>LEI: N/A                  | Long             |  | CORP              | CA        |      1880 | NS      | $1034.00      | 0.00%             |  |  |  | No            |                  2 | On Loan: —       |
| Amylyx Pharmaceuticals, Inc.                   | Amylyx Pharmaceuticals, Inc.                          | CUSIP: 03237H101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    687536 | NS      | $9556750.40   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Mineralys Therapeutics, Inc.                   | Mineralys Therapeutics, Inc.                          | CUSIP: 603170101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    439648 | NS      | $11910064.32  | 0.15%             |  |  |  | No            |                  1 | On Loan: —       |
| Medpace Holdings, Inc.                         | Medpace Holdings, Inc.                                | CUSIP: 58506Q109<br>LEI: 549300H8TYEUVTW14A54 | Long             | EC               | CORP              | US        |    169922 | NS      | $81594845.18  | 1.00%             |  |  |  | No            |                  1 | On Loan: —       |
| Repligen Corp.                                 | Repligen Corp.                                        | CUSIP: 759916109<br>LEI: 54930006QJ0T5AUO1E71 | Long             | EC               | CORP              | US        |    396896 | NS      | $46762286.72  | 0.58%             |  |  |  | No            |                  1 | On Loan: —       |
| Neurocrine Biosciences, Inc.                   | Neurocrine Biosciences, Inc.                          | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |    727502 | NS      | $95841113.48  | 1.18%             |  |  |  | No            |                  1 | On Loan: No      |
| MeiraGTx Holdings plc                          | MeiraGTx Holdings plc                                 | CUSIP: N/A<br>LEI: 54930007YV6NYIOGFZ57       | Long             | EC               | CORP              | KY        |    430643 | NS      | $3729368.38   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Absci Corp.                                    | Absci Corp.                                           | CUSIP: 00091E109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    975088 | NS      | $2925264.00   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Insmed, Inc.                                   | Insmed, Inc.                                          | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |   1587887 | NS      | $259651282.24 | 3.20%             |  |  |  | No            |                  1 | On Loan: —       |
| Dyne Therapeutics, Inc.                        | Dyne Therapeutics, Inc.                               | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    917470 | NS      | $16633731.10  | 0.20%             |  |  |  | No            |                  1 | On Loan: —       |
| Vera Therapeutics, Inc.                        | Vera Therapeutics, Inc., Class A                      | CUSIP: 92337R101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    419778 | NS      | $16887668.94  | 0.21%             |  |  |  | No            |                  1 | On Loan: —       |
| Rhythm Pharmaceuticals, Inc.                   | Rhythm Pharmaceuticals, Inc.                          | CUSIP: 76243J105<br>LEI: 529900JPNWXQ8DPLA551 | Long             | EC               | CORP              | US        |    474539 | NS      | $41270656.83  | 0.51%             |  |  |  | No            |                  1 | On Loan: —       |
| Biogen, Inc.                                   | Biogen, Inc.                                          | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |   1091046 | NS      | $200021463.18 | 2.46%             |  |  |  | No            |                  1 | On Loan: No      |
| OmniAb, Inc.                                   | OmniAb, Inc., 15.00 Earnout Shares                    | CUSIP: 68218J301<br>LEI: N/A                  | Long             |  | CORP              | US        |     46839 | NS      | $0.47         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Design Therapeutics, Inc.                      | Design Therapeutics, Inc.                             | CUSIP: 25056L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    235859 | NS      | $2509539.76   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Kura Oncology, Inc.                            | Kura Oncology, Inc.                                   | CUSIP: 50127T109<br>LEI: 5493005QORQTZCZYOP39 | Long             | EC               | CORP              | US        |    628449 | NS      | $5109290.37   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Tarsus Pharmaceuticals, Inc.                   | Tarsus Pharmaceuticals, Inc.                          | CUSIP: 87650L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    297522 | NS      | $20871168.30  | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Charles River Laboratories International, Inc. | Charles River Laboratories International, Inc.        | CUSIP: 159864107<br>LEI: 549300BSQ0R4UZ5KX287 | Long             | EC               | CORP              | US        |    362165 | NS      | $62473462.50  | 0.77%             |  |  |  | No            |                  1 | On Loan: —       |
| Nurix Therapeutics, Inc.                       | Nurix Therapeutics, Inc.                              | CUSIP: 67080M103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    720848 | NS      | $11173144.00  | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| Caribou Biosciences, Inc.                      | Caribou Biosciences, Inc.                             | CUSIP: 142038108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    594484 | NS      | $1129519.60   | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Phathom Pharmaceuticals, Inc.                  | Phathom Pharmaceuticals, Inc.                         | CUSIP: 71722W107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    356945 | NS      | $3965658.95   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Immuneering Corp.                              | Immuneering Corp., Class A                            | CUSIP: 45254E107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    390008 | NS      | $2055342.16   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Entrada Therapeutics, Inc.                     | Entrada Therapeutics, Inc.                            | CUSIP: 29384C108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    158267 | NS      | $1997329.54   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Alpha Teknova, Inc.                            | Alpha Teknova, Inc.                                   | CUSIP: 02080L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     79636 | NS      | $230148.04    | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| Editas Medicine, Inc.                          | Editas Medicine, Inc.                                 | CUSIP: 28106W103<br>LEI: 5299000AON4Q9NT2JE42 | Long             | EC               | CORP              | US        |    731163 | NS      | $1805972.61   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Ironwood Pharmaceuticals, Inc.                 | Ironwood Pharmaceuticals, Inc., Class A               | CUSIP: 46333X108<br>LEI: 549300PC8MR6QHH6P296 | Long             | EC               | CORP              | US        |   1173471 | NS      | $4118883.21   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Allogene Therapeutics, Inc.                    | Allogene Therapeutics, Inc.                           | CUSIP: 019770106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1145572 | NS      | $2795195.68   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Edgewise Therapeutics, Inc.                    | Edgewise Therapeutics, Inc.                           | CUSIP: 28036F105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    572192 | NS      | $18024048.00  | 0.22%             |  |  |  | No            |                  1 | On Loan: —       |
| Argenx SE                                      | Argenx SE                                             | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |    341883 | NS      | $249660060.75 | 3.07%             |  |  |  | No            |                  1 | On Loan: —       |
| BlackRock Funds III                            | BlackRock Cash Funds: Institutional, SL Agency Shares | CUSIP: 066922519<br>LEI: 549300JDHS1T46VWOG19 | Long             | STIV             | RF                | US        | 784655767 | NS      | $784812698.34 | 9.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Aura Biosciences, Inc.                         | Aura Biosciences, Inc.                                | CUSIP: 05153U107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    338128 | NS      | $2262076.32   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Genmab A/S                                     | Genmab A/S                                            | CUSIP: 372303206<br>LEI: 529900MTJPDPE4MHJ122 | Long             | EC               | CORP              | DK        |   3555098 | NS      | $95383279.34  | 1.17%             |  |  |  | No            |                  1 | On Loan: —       |
| Recursion Pharmaceuticals, Inc.                | Recursion Pharmaceuticals, Inc., Class A              | CUSIP: 75629V104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   3419857 | NS      | $10498960.99  | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Zai Lab Ltd.                                   | Zai Lab Ltd.                                          | CUSIP: 98887Q104<br>LEI: 549300P2UYQ9U5LY1T58 | Long             | EC               | CORP              | KY        |    613747 | NS      | $11544581.07  | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| Olema Pharmaceuticals, Inc.                    | Olema Pharmaceuticals, Inc.                           | CUSIP: 68062P106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    457751 | NS      | $6825067.41   | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Revolution Medicines, Inc.                     | Revolution Medicines, Inc.                            | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |   1283912 | NS      | $124860442.00 | 1.54%             |  |  |  | No            |                  1 | On Loan: —       |
| Standard BioTools, Inc.                        | Standard BioTools, Inc.                               | CUSIP: 34385P108<br>LEI: 549300GX8Y96GSB6YP89 | Long             | EC               | CORP              | US        |   2747556 | NS      | $2525828.23   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| 10X Genomics, Inc.                             | 10X Genomics, Inc., Class A                           | CUSIP: 88025U109<br>LEI: 5493003Z6741WNLG7H43 | Long             | EC               | CORP              | US        |    841716 | NS      | $17869630.68  | 0.22%             |  |  |  | No            |                  1 | On Loan: —       |
| Myriad Genetics, Inc.                          | Myriad Genetics, Inc.                                 | CUSIP: 62855J104<br>LEI: 52990044IHUOUMETT163 | Long             | EC               | CORP              | US        |    662895 | NS      | $2983027.50   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Disc Medicine, Inc.                            | Disc Medicine, Inc.                                   | CUSIP: 254604101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    214889 | NS      | $13740002.66  | 0.17%             |  |  |  | No            |                  1 | On Loan: —       |
| Bio-Techne Corp.                               | Bio-Techne Corp.                                      | CUSIP: 09073M104<br>LEI: 54930073RLKQ51TILZ35 | Long             | EC               | CORP              | US        |   1151950 | NS      | $60200907.00  | 0.74%             |  |  |  | No            |                  1 | On Loan: —       |
| Kodiak Sciences, Inc.                          | Kodiak Sciences, Inc.                                 | CUSIP: 50015M109<br>LEI: 254900IXI5NI8C9OQE24 | Long             | EC               | CORP              | US        |    422431 | NS      | $16103069.72  | 0.20%             |  |  |  | No            |                  1 | On Loan: —       |
| Theravance Biopharma, Inc.                     | Theravance Biopharma, Inc.                            | CUSIP: N/A<br>LEI: 5493007VTSXP4Z6MIW52       | Long             | EC               | CORP              | KY        |    353652 | NS      | $5739771.96   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| ADC Therapeutics SA                            | ADC Therapeutics SA                                   | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | CH        |    673142 | NS      | $2524282.50   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Tempus AI, Inc.                                | Tempus AI, Inc., Class A                              | CUSIP: 88023B103<br>LEI: 2549009LA0KWRAGQBX50 | Long             | EC               | CORP              | US        |    773906 | NS      | $34996029.32  | 0.43%             |  |  |  | No            |                  1 | On Loan: —       |
| Contineum Therapeutics, Inc.                   | Contineum Therapeutics, Inc., Class A                 | CUSIP: 21217B100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    200362 | NS      | $2616727.72   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Fortrea Holdings, Inc.                         | Fortrea Holdings, Inc.                                | CUSIP: 34965K107<br>LEI: 5493000FIVFABOVCDU97 | Long             | EC               | CORP              | US        |    693057 | NS      | $6528596.94   | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| WaVe Life Sciences Ltd.                        | WaVe Life Sciences Ltd.                               | CUSIP: N/A<br>LEI: 54930070006GPKFYZ813       | Long             | EC               | CORP              | SG        |   1176186 | NS      | $8527348.50   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| BioAge Labs, Inc.                              | BioAge Labs, Inc.                                     | CUSIP: 09077V100<br>LEI: 529900NG0C40250Z7875 | Long             | EC               | CORP              | US        |    211362 | NS      | $3696721.38   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Ideaya Biosciences, Inc.                       | Ideaya Biosciences, Inc.                              | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |    615636 | NS      | $20512991.52  | 0.25%             |  |  |  | No            |                  1 | On Loan: —       |
| Cytek Biosciences, Inc.                        | Cytek Biosciences, Inc.                               | CUSIP: 23285D109<br>LEI: 549300K2J28BOC6FBO89 | Long             | EC               | CORP              | US        |    868726 | NS      | $3796332.62   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Bruker Corp.                                   | Bruker Corp.                                          | CUSIP: 116794108<br>LEI: LEBZ6VLQ6I8XB1NHVY15 | Long             | EC               | CORP              | US        |    764342 | NS      | $27608033.04  | 0.34%             |  |  |  | No            |                  1 | On Loan: —       |
| Roivant Sciences Ltd.                          | Roivant Sciences Ltd.                                 | CUSIP: N/A<br>LEI: 549300DL466NY5J6U724       | Long             | EC               | CORP              | BM        |   3642557 | NS      | $100898828.90 | 1.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Praxis Precision Medicines, Inc.               | Praxis Precision Medicines, Inc.                      | CUSIP: 74006W207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    195097 | NS      | $62858302.43  | 0.77%             |  |  |  | No            |                  1 | On Loan: —       |
| Twist Bioscience Corp.                         | Twist Bioscience Corp.                                | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |    436795 | NS      | $20756498.40  | 0.26%             |  |  |  | No            |                  1 | On Loan: —       |
| Cytokinetics, Inc.                             | Cytokinetics, Inc.                                    | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |    896972 | NS      | $59119424.52  | 0.73%             |  |  |  | No            |                  1 | On Loan: —       |
| OmniAb, Inc.                                   | OmniAb, Inc.                                          | CUSIP: 68218J103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    874147 | NS      | $1372410.79   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Lineage Cell Therapeutics, Inc.                | Lineage Cell Therapeutics, Inc.                       | CUSIP: 53566P109<br>LEI: 5299002BI4W22SDF8R25 | Long             | EC               | CORP              | US        |   1621430 | NS      | $2561859.40   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Arcturus Therapeutics Holdings, Inc.           | Arcturus Therapeutics Holdings, Inc.                  | CUSIP: 03969T109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    186967 | NS      | $1443385.24   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Illumina, Inc.                                 | Illumina, Inc.                                        | CUSIP: 452327109<br>LEI: SQ95QG8SR5Q56LSNF682 | Long             | EC               | CORP              | US        |   1107291 | NS      | $136484688.66 | 1.68%             |  |  |  | No            |                  1 | On Loan: —       |
| Exelixis, Inc.                                 | Exelixis, Inc.                                        | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |   1871326 | NS      | $80261172.14  | 0.99%             |  |  |  | No            |                  1 | On Loan: No      |
| Quanterix Corp.                                | Quanterix Corp.                                       | CUSIP: 74766Q101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    284827 | NS      | $1002591.04   | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Prothena Corp. plc                             | Prothena Corp. plc                                    | CUSIP: N/A<br>LEI: 5299009ZXQ8NIIJ8OL30       | Long             | EC               | CORP              | IE        |    323349 | NS      | $3142952.28   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Day One Biopharmaceuticals, Inc.               | Day One Biopharmaceuticals, Inc.                      | CUSIP: 23954D109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    578773 | NS      | $12408893.12  | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Aardvark Therapeutics, Inc.                    | Aardvark Therapeutics, Inc.                           | CUSIP: 002942100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     89682 | NS      | $338101.14    | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| Galapagos NV                                   | Galapagos NV                                          | CUSIP: 36315X101<br>LEI: 549300QKJ78IY0IOV655 | Long             | EC               | CORP              | BE        |    271893 | NS      | $8156790.00   | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| Replimune Group, Inc.                          | Replimune Group, Inc.                                 | CUSIP: 76029N106<br>LEI: 549300AY704NEIRC4K64 | Long             | EC               | CORP              | US        |    570930 | NS      | $4367614.50   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Janux Therapeutics, Inc.                       | Janux Therapeutics, Inc.                              | CUSIP: 47103J105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    392349 | NS      | $5453651.10   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Centessa Pharmaceuticals plc                   | Centessa Pharmaceuticals plc                          | CUSIP: 152309100<br>LEI: 213800GIDAARDSKOI827 | Long             | EC               | CORP              | GB        |    520762 | NS      | $20684666.64  | 0.25%             |  |  |  | No            |                  1 | On Loan: —       |
| Novocure Ltd.                                  | Novocure Ltd.                                         | CUSIP: N/A<br>LEI: 213800YPP55UMHWA4826       | Long             | EC               | CORP              | JE        |    763201 | NS      | $8318890.90   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Fulgent Genetics, Inc.                         | Fulgent Genetics, Inc.                                | CUSIP: 359664109<br>LEI: 549300CL6P01M68QJ404 | Long             | EC               | CORP              | US        |    148748 | NS      | $2365093.20   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Castle Biosciences, Inc.                       | Castle Biosciences, Inc.                              | CUSIP: 14843C105<br>LEI: 2549007M2Q4HLR1XD252 | Long             | EC               | CORP              | US        |    215689 | NS      | $5295164.95   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Xenon Pharmaceuticals, Inc.                    | Xenon Pharmaceuticals, Inc.                           | CUSIP: 98420N105<br>LEI: 549300XV44Q9Z1MIPQ03 | Long             | EC               | CORP              | CA        |    598390 | NS      | $34796378.50  | 0.43%             |  |  |  | No            |                  1 | On Loan: No      |
| Enanta Pharmaceuticals, Inc.                   | Enanta Pharmaceuticals, Inc.                          | CUSIP: 29251M106<br>LEI: 529900SSN4DODDQSN594 | Long             | EC               | CORP              | US        |    205184 | NS      | $2591473.92   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Amicus Therapeutics, Inc.                      | Amicus Therapeutics, Inc.                             | CUSIP: 03152W109<br>LEI: 549300MRD1SMUTNBPQ53 | Long             | EC               | CORP              | US        |   2307725 | NS      | $33369703.50  | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Cullinan Therapeutics, Inc.                    | Cullinan Therapeutics, Inc.                           | CUSIP: 230031106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    323429 | NS      | $4595926.09   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Perspective Therapeutics, Inc.                 | Perspective Therapeutics, Inc.                        | CUSIP: 46489V302<br>LEI: 5493005LRKM6BCABC605 | Long             | EC               | CORP              | US        |    693460 | NS      | $2891728.20   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| PTC Therapeutics, Inc.                         | PTC Therapeutics, Inc.                                | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |    593152 | NS      | $40411445.76  | 0.50%             |  |  |  | No            |                  1 | On Loan: —       |
| Ultragenyx Pharmaceutical, Inc.                | Ultragenyx Pharmaceutical, Inc.                       | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |    680286 | NS      | $14251991.70  | 0.18%             |  |  |  | No            |                  1 | On Loan: —       |
| Bicara Therapeutics, Inc.                      | Bicara Therapeutics, Inc.                             | CUSIP: 055477103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    236865 | NS      | $4711244.85   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Nuvalent, Inc.                                 | Nuvalent, Inc., Class A                               | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    355481 | NS      | $36419028.45  | 0.45%             |  |  |  | No            |                  1 | On Loan: —       |
| Codexis, Inc.                                  | Codexis, Inc.                                         | CUSIP: 192005106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    683417 | NS      | $1113969.71   | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Cabaletta Bio, Inc.                            | Cabaletta Bio, Inc.                                   | CUSIP: 12674W109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    633353 | NS      | $1703719.57   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Natera, Inc.                                   | Natera, Inc.                                          | CUSIP: 632307104<br>LEI: 529900CQ3OZ0A0VYVU59 | Long             | EC               | CORP              | US        |    980622 | NS      | $196114593.78 | 2.41%             |  |  |  | No            |                  1 | On Loan: No      |
| ArriVent Biopharma, Inc.                       | ArriVent Biopharma, Inc.                              | CUSIP: 04272N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    201242 | NS      | $4642652.94   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| CareDx, Inc.                                   | CareDx, Inc.                                          | CUSIP: 14167L103<br>LEI: 549300NQOFKL9NON0U06 | Long             | EC               | CORP              | US        |    337886 | NS      | $5865700.96   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| UroGen Pharma Ltd.                             | UroGen Pharma Ltd.                                    | CUSIP: N/A<br>LEI: 549300C0YCX7CG2G5D50       | Long             | EC               | CORP              | IL        |    286041 | NS      | $5143017.18   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Mirum Pharmaceuticals, Inc.                    | Mirum Pharmaceuticals, Inc.                           | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |    392677 | NS      | $36275501.26  | 0.45%             |  |  |  | No            |                  1 | On Loan: —       |
| Kyverna Therapeutics, Inc.                     | Kyverna Therapeutics, Inc.                            | CUSIP: 501976104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    251263 | NS      | $2168399.69   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| OPKO Health, Inc.                              | OPKO Health, Inc.                                     | CUSIP: 68375N103<br>LEI: 529900A4S2D4OGOJLL02 | Long             | EC               | CORP              | US        |   2882600 | NS      | $3286164.00   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Pacific Biosciences of California, Inc.        | Pacific Biosciences of California, Inc.               | CUSIP: 69404D108<br>LEI: 529900F1BWRE1M0KZN89 | Long             | EC               | CORP              | US        |   2021533 | NS      | $2668423.56   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Xencor, Inc.                                   | Xencor, Inc.                                          | CUSIP: 98401F105<br>LEI: 549300V5IF65437JKG30 | Long             | EC               | CORP              | US        |    513267 | NS      | $6190000.02   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Sarepta Therapeutics, Inc.                     | Sarepta Therapeutics, Inc.                            | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |    739607 | NS      | $16093848.32  | 0.20%             |  |  |  | No            |                  1 | On Loan: —       |
| Arcutis Biotherapeutics, Inc.                  | Arcutis Biotherapeutics, Inc.                         | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    814779 | NS      | $19196193.24  | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Summit Therapeutics, Inc.                      | Summit Therapeutics, Inc.                             | CUSIP: 86627T108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    799477 | NS      | $15158083.92  | 0.19%             |  |  |  | No            |                  1 | On Loan: —       |
| Abivax SA                                      | Abivax SA                                             | CUSIP: 00370M103<br>LEI: 969500D8TMNB184OJU95 | Long             | EC               | CORP              | FR        |    367461 | NS      | $40916782.35  | 0.50%             |  |  |  | No            |                  1 | On Loan: —       |
| Corvus Pharmaceuticals, Inc.                   | Corvus Pharmaceuticals, Inc.                          | CUSIP: 221015100<br>LEI: 549300I3AVJ8F75NCX65 | Long             | EC               | CORP              | US        |    473326 | NS      | $6924759.38   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Nuvation Bio, Inc.                             | Nuvation Bio, Inc., Class A                           | CUSIP: 67080N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1795888 | NS      | $7704359.52   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Atea Pharmaceuticals, Inc.                     | Atea Pharmaceuticals, Inc.                            | CUSIP: 04683R106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    460056 | NS      | $2475101.28   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| CG oncology, Inc.                              | CG oncology, Inc.                                     | CUSIP: 156944100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    379295 | NS      | $25670685.60  | 0.32%             |  |  |  | No            |                  1 | On Loan: —       |
| Iovance Biotherapeutics, Inc.                  | Iovance Biotherapeutics, Inc.                         | CUSIP: 462260100<br>LEI: 2549002L8WT2ACU5Q878 | Long             | EC               | CORP              | US        |   2619021 | NS      | $9192763.71   | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| MBX Biosciences, Inc.                          | MBX Biosciences, Inc.                                 | CUSIP: 55287L101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    199599 | NS      | $5958030.15   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Annexon, Inc.                                  | Annexon, Inc.                                         | CUSIP: 03589W102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    952884 | NS      | $5278977.36   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Syndax Pharmaceuticals, Inc.                   | Syndax Pharmaceuticals, Inc.                          | CUSIP: 87164F105<br>LEI: 529900OF94TRHKZVBS87 | Long             | EC               | CORP              | US        |    631524 | NS      | $14752400.64  | 0.18%             |  |  |  | No            |                  1 | On Loan: —       |
| Black Diamond Therapeutics, Inc.               | Black Diamond Therapeutics, Inc.                      | CUSIP: 09203E105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    321542 | NS      | $684884.46    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Alnylam Pharmaceuticals, Inc.                  | Alnylam Pharmaceuticals, Inc.                         | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |    979642 | NS      | $324134148.54 | 3.99%             |  |  |  | No            |                  1 | On Loan: No      |
| Inhibrx Biosciences, Inc.                      | Inhibrx Biosciences, Inc.                             | CUSIP: 45720N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     75835 | NS      | $5098387.05   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Vaxcyte, Inc.                                  | Vaxcyte, Inc.                                         | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |   1045695 | NS      | $60765336.45  | 0.75%             |  |  |  | No            |                  1 | On Loan: —       |
| Keros Therapeutics, Inc.                       | Keros Therapeutics, Inc.                              | CUSIP: 492327101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    214789 | NS      | $2371270.56   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Ascendis Pharma A/S                            | Ascendis Pharma A/S                                   | CUSIP: 04351P101<br>LEI: 549300B66JN3W3J8GH73 | Long             | EC               | CORP              | DK        |    339948 | NS      | $77756306.04  | 0.96%             |  |  |  | No            |                  1 | On Loan: —       |
| Novavax, Inc.                                  | Novavax, Inc.                                         | CUSIP: 670002401<br>LEI: 529900J4GJHPEPQ23205 | Long             | EC               | CORP              | US        |   1157114 | NS      | $9418907.96   | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Beam Therapeutics, Inc.                        | Beam Therapeutics, Inc.                               | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    692124 | NS      | $16493314.92  | 0.20%             |  |  |  | No            |                  1 | On Loan: —       |
| Oruka Therapeutics, Inc.                       | Oruka Therapeutics, Inc.                              | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |    304331 | NS      | $14927435.55  | 0.18%             |  |  |  | No            |                  1 | On Loan: —       |
| Taysha Gene Therapies, Inc.                    | Taysha Gene Therapies, Inc.                           | CUSIP: 877619106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1672180 | NS      | $7474644.60   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Agios Pharmaceuticals, Inc.                    | Agios Pharmaceuticals, Inc.                           | CUSIP: 00847X104<br>LEI: 529900ONJHY8EOGYT555 | Long             | EC               | CORP              | US        |    400087 | NS      | $13534943.21  | 0.17%             |  |  |  | No            |                  1 | On Loan: —       |
| Ginkgo Bioworks Holdings, Inc.                 | Ginkgo Bioworks Holdings, Inc.                        | CUSIP: 37611X209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    317323 | NS      | $1945189.99   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Axsome Therapeutics, Inc.                      | Axsome Therapeutics, Inc.                             | CUSIP: 05464T104<br>LEI: 549300EXGR0XLRJEIB95 | Long             | EC               | CORP              | US        |    319088 | NS      | $53932253.76  | 0.66%             |  |  |  | No            |                  1 | On Loan: —       |
| Humacyte, Inc.                                 | Humacyte, Inc.                                        | CUSIP: 44486Q103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1222120 | NS      | $741460.20    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| ADMA Biologics, Inc.                           | ADMA Biologics, Inc.                                  | CUSIP: 000899104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1711239 | NS      | $15418263.39  | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Alvotech SA                                    | Alvotech SA                                           | CUSIP: N/A<br>LEI: 222100DCZBOWV5DZ8372       | Long             | EC               | CORP              | LU        |    763481 | NS      | $2618739.83   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Newamsterdam Pharma Co. NV                     | Newamsterdam Pharma Co. NV                            | CUSIP: N/A<br>LEI: 984500B6549TF6E14D36       | Long             | EC               | CORP              | NL        |    537784 | NS      | $17214465.84  | 0.21%             |  |  |  | No            |                  1 | On Loan: —       |
| Crinetics Pharmaceuticals, Inc.                | Crinetics Pharmaceuticals, Inc.                       | CUSIP: 22663K107<br>LEI: 549300Q1CNFXK5P31D28 | Long             | EC               | CORP              | US        |    726428 | NS      | $26383864.96  | 0.32%             |  |  |  | No            |                  1 | On Loan: —       |
| AnaptysBio, Inc.                               | AnaptysBio, Inc.                                      | CUSIP: 032724106<br>LEI: 529900HH4WQT03IG1A12 | Long             | EC               | CORP              | US        |    192136 | NS      | $10655862.56  | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Alto Neuroscience, Inc.                        | Alto Neuroscience, Inc.                               | CUSIP: 02157Q109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    212677 | NS      | $4780978.96   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Arcus Biosciences, Inc.                        | Arcus Biosciences, Inc.                               | CUSIP: 03969F109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    612355 | NS      | $13226868.00  | 0.16%             |  |  |  | No            |                  1 | On Loan: —       |
| Arvinas, Inc.                                  | Arvinas, Inc.                                         | CUSIP: 04335A105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    403100 | NS      | $4272860.00   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Geron Corp.                                    | Geron Corp.                                           | CUSIP: 374163103<br>LEI: 549300T282D7Z2YESL90 | Long             | EC               | CORP              | US        |   4513103 | NS      | $6724523.47   | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Vanda Pharmaceuticals, Inc.                    | Vanda Pharmaceuticals, Inc.                           | CUSIP: 921659108<br>LEI: 529900AY8VOOQBKJ0O70 | Long             | EC               | CORP              | US        |    405038 | NS      | $2798812.58   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Autolus Therapeutics plc                       | Autolus Therapeutics plc                              | CUSIP: 05280R100<br>LEI: 549300C0KZP8EYROLL02 | Long             | EC               | CORP              | GB        |   1321681 | NS      | $1823919.78   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| ACADIA Pharmaceuticals, Inc.                   | ACADIA Pharmaceuticals, Inc.                          | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |   1251241 | NS      | $27852624.66  | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals, Inc.                   | Vertex Pharmaceuticals, Inc.                          | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |   1354033 | NS      | $604629895.82 | 7.44%             |  |  |  | No            |                  1 | On Loan: —       |
| Cogent Biosciences, Inc.                       | Cogent Biosciences, Inc.                              | CUSIP: 19240Q201<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1009396 | NS      | $38851652.04  | 0.48%             |  |  |  | No            |                  1 | On Loan: —       |
| ARS Pharmaceuticals, Inc.                      | ARS Pharmaceuticals, Inc.                             | CUSIP: 82835W108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    463404 | NS      | $3721134.12   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| REGENXBIO, Inc.                                | REGENXBIO, Inc.                                       | CUSIP: 75901B107<br>LEI: 549300EOES47LATSET33 | Long             | EC               | CORP              | US        |    331423 | NS      | $2777324.74   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| BioCryst Pharmaceuticals, Inc.                 | BioCryst Pharmaceuticals, Inc.                        | CUSIP: 09058V103<br>LEI: 549300Z0INP1Z5NP6J59 | Long             | EC               | CORP              | US        |   1715826 | NS      | $16334663.52  | 0.20%             |  |  |  | No            |                  1 | On Loan: —       |
| Septerna, Inc.                                 | Septerna, Inc.                                        | CUSIP: 81734D104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    200845 | NS      | $4826305.35   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| LENZ Therapeutics, Inc.                        | LENZ Therapeutics, Inc.                               | CUSIP: 52635N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    206971 | NS      | $1893784.65   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Sagimet Biosciences, Inc.                      | Sagimet Biosciences, Inc., Class A                    | CUSIP: 786700104<br>LEI: 2549002OT2F8BV0VPD02 | Long             | EC               | CORP              | US        |    189187 | NS      | $988502.08    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Rapport Therapeutics, Inc.                     | Rapport Therapeutics, Inc.                            | CUSIP: 75383L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    217759 | NS      | $6813679.11   | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Legend Biotech Corp.                           | Legend Biotech Corp.                                  | CUSIP: 52490G102<br>LEI: 254900EIUFZTW136H859 | Long             | EC               | CORP              | KY        |    983928 | NS      | $17799257.52  | 0.22%             |  |  |  | No            |                  1 | On Loan: —       |
| Arrowhead Pharmaceuticals, Inc.                | Arrowhead Pharmaceuticals, Inc.                       | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |    975175 | NS      | $61143472.50  | 0.75%             |  |  |  | No            |                  1 | On Loan: —       |
| Stevanato Group SpA                            | Stevanato Group SpA                                   | CUSIP: N/A<br>LEI: 81560033F7E1CD477507       | Long             | EC               | CORP              | IT        |    370391 | NS      | $5092876.25   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Zymeworks, Inc.                                | Zymeworks, Inc.                                       | CUSIP: 98985Y108<br>LEI: 894500AHOYAGYLYZJL67 | Long             | EC               | CORP              | US        |    529981 | NS      | $13270724.24  | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Contra Chinook Therape                         | Contra Chinook Therape, CVR                           | CUSIP: 169CVR016<br>LEI: N/A                  | Long             |  | CORP              | US        |    320962 | NS      | $54563.54     | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Immunovant, Inc.                               | Immunovant, Inc.                                      | CUSIP: 45258J102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    626211 | NS      | $15555081.24  | 0.19%             |  |  |  | No            |                  1 | On Loan: —       |
| GRAIL, Inc.                                    | GRAIL, Inc.                                           | CUSIP: 384747101<br>LEI: 2549009XSNESW3VE8024 | Long             | EC               | CORP              | US        |    261045 | NS      | $13490805.60  | 0.17%             |  |  |  | No            |                  1 | On Loan: —       |
| Silence Therapeutics plc                       | Silence Therapeutics plc                              | CUSIP: 82686Q101<br>LEI: 213800SSURRJBX85SQ91 | Long             | EC               | CORP              | GB        |    173313 | NS      | $913359.51    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Vir Biotechnology, Inc.                        | Vir Biotechnology, Inc.                               | CUSIP: 92764N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    704449 | NS      | $6311863.04   | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Prime Medicine, Inc.                           | Prime Medicine, Inc.                                  | CUSIP: 74168J101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    704092 | NS      | $2450240.16   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Third Harmonic Bio, Inc.                       | Third Harmonic Bio, Inc.                              | CUSIP: 88427A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    134478 | NS      | $1.34         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Maravai LifeSciences Holdings, Inc.            | Maravai LifeSciences Holdings, Inc., Class A          | CUSIP: 56600D107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    759052 | NS      | $2148117.16   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Intellia Therapeutics, Inc.                    | Intellia Therapeutics, Inc.                           | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |    835337 | NS      | $10709020.34  | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| NovaBridge Biosciences                         | NovaBridge Biosciences                                | CUSIP: 44975P103<br>LEI: 549300L1A5T19703RR64 | Long             | EC               | CORP              | KY        |    539518 | NS      | $1327214.28   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Zenas Biopharma, Inc.                          | Zenas Biopharma, Inc.                                 | CUSIP: 98937L105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    175941 | NS      | $3439646.55   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Mesoblast Ltd.                                 | Mesoblast Ltd.                                        | CUSIP: 590717401<br>LEI: 529900J5ALF3JG921927 | Long             | EC               | CORP              | AU        |    460143 | NS      | $7076999.34   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Precigen, Inc.                                 | Precigen, Inc.                                        | CUSIP: 74017N105<br>LEI: 549300XCWNQU35K64G19 | Long             | EC               | CORP              | US        |   1104713 | NS      | $4275239.31   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Aurinia Pharmaceuticals, Inc.                  | Aurinia Pharmaceuticals, Inc.                         | CUSIP: 05156V102<br>LEI: 5299008YP2BW4570ML28 | Long             | EC               | CORP              | CA        |    874336 | NS      | $12957659.52  | 0.16%             |  |  |  | No            |                  1 | On Loan: —       |
| Scholar Rock Holding Corp.                     | Scholar Rock Holding Corp.                            | CUSIP: 80706P103<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |    593730 | NS      | $29187766.80  | 0.36%             |  |  |  | No            |                  1 | On Loan: —       |
| Altimmune, Inc.                                | Altimmune, Inc.                                       | CUSIP: 02155H200<br>LEI: 549300EOYCQ8SW3NVE64 | Long             | EC               | CORP              | US        |    926610 | NS      | $2853958.80   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Rigel Pharmaceuticals, Inc.                    | Rigel Pharmaceuticals, Inc.                           | CUSIP: 766559702<br>LEI: 529900KPTNUS5J8K9K66 | Long             | EC               | CORP              | US        |    131031 | NS      | $3543078.24   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Upstream Bio, Inc.                             | Upstream Bio, Inc.                                    | CUSIP: 91678A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    213032 | NS      | $1917288.00   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Protagonist Therapeutics, Inc.                 | Protagonist Therapeutics, Inc.                        | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    447047 | NS      | $47118753.80  | 0.58%             |  |  |  | No            |                  1 | On Loan: —       |
| ImmunityBio, Inc.                              | ImmunityBio, Inc.                                     | CUSIP: 45256X103<br>LEI: 529900J9XLBR4HFL4B83 | Long             | EC               | CORP              | US        |   2572701 | NS      | $19732616.67  | 0.24%             |  |  |  | No            |                  1 | On Loan: —       |
| Travere Therapeutics, Inc.                     | Travere Therapeutics, Inc.                            | CUSIP: 89422G107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    674600 | NS      | $20042366.00  | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Bridgebio Pharma, Inc.                         | Bridgebio Pharma, Inc.                                | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |   1238687 | NS      | $91984896.62  | 1.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Cellectis SA                                   | Cellectis SA                                          | CUSIP: 15117K103<br>LEI: 5493000KKX5VQ37Q2W83 | Long             | EC               | CORP              | FR        |    339873 | NS      | $1077397.41   | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| BridgeBio Oncology Therapeutics, Inc.          | BridgeBio Oncology Therapeutics, Inc.                 | CUSIP: 107924102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    324513 | NS      | $2904391.35   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| BeOne Medicines Ltd.                           | BeOne Medicines Ltd.                                  | CUSIP: 07725L102<br>LEI: 549300JFUK6FRD5MH739 | Long             | EC               | CORP              | CH        |    529143 | NS      | $157139596.71 | 1.93%             |  |  |  | No            |                  1 | On Loan: —       |
| Cartesian Therapeutics, Inc.                   | Cartesian Therapeutics, Inc.                          | CUSIP: 816212112<br>LEI: 529900NMN0LACZOL7C43 | Long             |  | CORP              | US        |      6098 | NS      | $1585.48      | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Adaptive Biotechnologies Corp.                 | Adaptive Biotechnologies Corp.                        | CUSIP: 00650F109<br>LEI: 549300ZTF7OT1FW66Q96 | Long             | EC               | CORP              | US        |   1105997 | NS      | $15351238.36  | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Jyong Biotech Ltd.                             | Jyong Biotech Ltd.                                    | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | KY        |    206499 | NS      | $443972.85    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Rocket Pharmaceuticals, Inc.                   | Rocket Pharmaceuticals, Inc.                          | CUSIP: 77313F106<br>LEI: 549300R7VV82YUIN4Y93 | Long             | EC               | CORP              | US        |    752567 | NS      | $2694189.86   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Larimar Therapeutics, Inc.                     | Larimar Therapeutics, Inc.                            | CUSIP: 517125100<br>LEI: 529900NCBZHTTJV6HX73 | Long             | EC               | CORP              | US        |    350415 | NS      | $1576867.50   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Arcellx, Inc.                                  | Arcellx, Inc.                                         | CUSIP: 03940C100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    335814 | NS      | $38558163.48  | 0.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Amgen, Inc.                                    | Amgen, Inc.                                           | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |   1733148 | NS      | $609808123.80 | 7.51%             |  |  |  | No            |                  1 | On Loan: No      |
| C4 Therapeutics, Inc.                          | C4 Therapeutics, Inc.                                 | CUSIP: 12529R107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    608839 | NS      | $1601246.57   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Halozyme Therapeutics, Inc.                    | Halozyme Therapeutics, Inc.                           | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |    868502 | NS      | $56131284.26  | 0.69%             |  |  |  | No            |                  1 | On Loan: —       |
| Candel Therapeutics, Inc.                      | Candel Therapeutics, Inc.                             | CUSIP: 137404109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    294995 | NS      | $1445475.50   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Spyre Therapeutics, Inc.                       | Spyre Therapeutics, Inc.                              | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |    478909 | NS      | $24156169.96  | 0.30%             |  |  |  | No            |                  1 | On Loan: —       |
| KalVista Pharmaceuticals, Inc.                 | KalVista Pharmaceuticals, Inc.                        | CUSIP: 483497103<br>LEI: 529900Q7IDA3WUGRZA51 | Long             | EC               | CORP              | US        |    276916 | NS      | $5574319.08   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Krystal Biotech, Inc.                          | Krystal Biotech, Inc.                                 | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |    188966 | NS      | $48813697.12  | 0.60%             |  |  |  | No            |                  1 | On Loan: —       |
| Lyell Immunopharma, Inc.                       | Lyell Immunopharma, Inc.                              | CUSIP: 55083R203<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     54413 | NS      | $1091524.78   | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| BlackRock Funds III                            | BlackRock Cash Funds: Treasury, SL Agency Shares      | CUSIP: 066922477<br>LEI: 5493005PQV5UQG4OSI49 | Long             | STIV             | RF                | US        |  12996156 | NS      | $12996156.43  | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Monte Rosa Therapeutics, Inc.                  | Monte Rosa Therapeutics, Inc.                         | CUSIP: 61225M102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    346430 | NS      | $5698773.50   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Personalis, Inc.                               | Personalis, Inc.                                      | CUSIP: 71535D106<br>LEI: 549300EZ2NYFK7H0US48 | Long             | EC               | CORP              | US        |    393153 | NS      | $2504384.61   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Relay Therapeutics, Inc.                       | Relay Therapeutics, Inc.                              | CUSIP: 75943R102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    980266 | NS      | $9753646.70   | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Fulcrum Therapeutics, Inc.                     | Fulcrum Therapeutics, Inc.                            | CUSIP: 359616109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    429371 | NS      | $3293275.57   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Regeneron Pharmaceuticals, Inc.                | Regeneron Pharmaceuticals, Inc.                       | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |    758232 | NS      | $585840372.48 | 7.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Tectonic Therapeutic, Inc.                     | Tectonic Therapeutic, Inc.                            | CUSIP: 878972108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     75889 | NS      | $2345728.99   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| CRISPR Therapeutics AG                         | CRISPR Therapeutics AG                                | CUSIP: N/A<br>LEI: 506700O6IRRIQLT3W370       | Long             | EC               | CORP              | CH        |    663733 | NS      | $31573778.81  | 0.39%             |  |  |  | No            |                  1 | On Loan: —       |
| Pyxis Oncology, Inc.                           | Pyxis Oncology, Inc.                                  | CUSIP: 747324101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    345130 | NS      | $503889.80    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Gilead Sciences, Inc.                          | Gilead Sciences, Inc.                                 | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |   4515707 | NS      | $629354084.59 | 7.75%             |  |  |  | No            |                  1 | On Loan: No      |
| Sana Biotechnology, Inc.                       | Sana Biotechnology, Inc.                              | CUSIP: 799566104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1235916 | NS      | $3559438.08   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| PepGen, Inc.                                   | PepGen, Inc.                                          | CUSIP: 713317105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    451333 | NS      | $798859.41    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Apellis Pharmaceuticals, Inc.                  | Apellis Pharmaceuticals, Inc.                         | CUSIP: 03753U106<br>LEI: 254900HS0ZFRXXSB9D42 | Long             | EC               | CORP              | US        |    778245 | NS      | $31308796.35  | 0.39%             |  |  |  | No            |                  1 | On Loan: —       |
| Incyte Corp.                                   | Incyte Corp.                                          | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |   1467923 | NS      | $138160912.76 | 1.70%             |  |  |  | No            |                  1 | On Loan: —       |
| Gossamer Bio, Inc.                             | Gossamer Bio, Inc.                                    | CUSIP: 38341P102<br>LEI: 549300ZOC0N2W6PSFR58 | Long             | EC               | CORP              | US        |   1510536 | NS      | $496211.08    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| CytomX Therapeutics, Inc.                      | CytomX Therapeutics, Inc.                             | CUSIP: 23284F105<br>LEI: 5493004VW2FW0QLL3345 | Long             | EC               | CORP              | US        |    987397 | NS      | $4640765.90   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Structure Therapeutics, Inc.                   | Structure Therapeutics, Inc.                          | CUSIP: 86366E106<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |    381676 | NS      | $18396783.20  | 0.23%             |  |  |  | No            |                  1 | On Loan: —       |
| Grifols SA                                     | Grifols SA                                            | CUSIP: 398438408<br>LEI: 959800HSSNXWRKBK4N60 | Long             | EC               | CORP              | ES        |    976161 | NS      | $7828811.22   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Denali Therapeutics, Inc.                      | Denali Therapeutics, Inc.                             | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |   1055210 | NS      | $20260032.00  | 0.25%             |  |  |  | No            |                  1 | On Loan: —       |
| AC Immune SA                                   | AC Immune SA                                          | CUSIP: N/A<br>LEI: 967600VLQ0ZC2HSOG765       | Long             | EC               | CORP              | CH        |    443438 | NS      | $1219454.50   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Biohaven Ltd.                                  | Biohaven Ltd.                                         | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | VG        |    917535 | NS      | $7762346.10   | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| AbCellera Biologics, Inc.                      | AbCellera Biologics, Inc.                             | CUSIP: 00288U106<br>LEI: 9845000861BC95FF9F73 | Long             | EC               | CORP              | CA        |   1732022 | NS      | $6044756.78   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Immunocore Holdings plc                        | Immunocore Holdings plc                               | CUSIP: 45258D105<br>LEI: 213800IUE3DFS84BVN18 | Long             | EC               | CORP              | GB        |    277185 | NS      | $8357127.75   | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| Pharvaris NV                                   | Pharvaris NV                                          | CUSIP: N/A<br>LEI: 9845003BE146D3B75D32       | Long             | EC               | CORP              | NL        |    191961 | NS      | $5422898.25   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| BioNTech SE                                    | BioNTech SE                                           | CUSIP: 09075V102<br>LEI: 894500UZJ5LG1F8J1U58 | Long             | EC               | CORP              | DE        |    599506 | NS      | $53284093.28  | 0.66%             |  |  |  | No            |                  1 | On Loan: —       |
| Zevra Therapeutics, Inc.                       | Zevra Therapeutics, Inc.                              | CUSIP: 488445206<br>LEI: 254900CU6T74V18Y1W18 | Long             | EC               | CORP              | US        |    413742 | NS      | $3856075.44   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Foghorn Therapeutics, Inc.                     | Foghorn Therapeutics, Inc.                            | CUSIP: 344174107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    223190 | NS      | $1066848.20   | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Arbutus Biopharma Corp.                        | Arbutus Biopharma Corp.                               | CUSIP: 03879J100<br>LEI: 25490064CESONAUIAS23 | Long             | EC               | CORP              | CA        |   1119437 | NS      | $5037466.50   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Vericel Corp.                                  | Vericel Corp.                                         | CUSIP: 92346J108<br>LEI: 54930076YM3PLTDR4B91 | Long             | EC               | CORP              | US        |    373502 | NS      | $12015559.34  | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Trevi Therapeutics, Inc.                       | Trevi Therapeutics, Inc.                              | CUSIP: 89532M101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    608481 | NS      | $7259178.33   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Voyager Therapeutics, Inc.                     | Voyager Therapeutics, Inc.                            | CUSIP: 92915B106<br>LEI: 54930082S4XVR0ZWCC74 | Long             | EC               | CORP              | US        |    329043 | NS      | $1270105.98   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Caris Life Sciences, Inc.                      | Caris Life Sciences, Inc.                             | CUSIP: 142152107<br>LEI: 549300LX5LO78M5VPY43 | Long             | EC               | CORP              | US        |    898011 | NS      | $16056436.68  | 0.20%             |  |  |  | No            |                  1 | On Loan: —       |
| Erasca, Inc.                                   | Erasca, Inc.                                          | CUSIP: 29479A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1384399 | NS      | $22399575.82  | 0.28%             |  |  |  | No            |                  1 | On Loan: —       |
| Emergent BioSolutions, Inc.                    | Emergent BioSolutions, Inc.                           | CUSIP: 29089Q105<br>LEI: 549300YW6TUOX8BE5103 | Long             | EC               | CORP              | US        |    376503 | NS      | $3124974.90   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Sionna Therapeutics, Inc.                      | Sionna Therapeutics, Inc.                             | CUSIP: 829401108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    185101 | NS      | $7420699.09   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Aclaris Therapeutics, Inc.                     | Aclaris Therapeutics, Inc.                            | CUSIP: 00461U105<br>LEI: 5493000B2LQ9QTW1DF52 | Long             | EC               | CORP              | US        |    766012 | NS      | $2872545.00   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Immutep Ltd.                                   | Immutep Ltd.                                          | CUSIP: 45257L108<br>LEI: 529900OL6C5CY5P8BH38 | Long             | EC               | CORP              | AU        |    809244 | NS      | $284044.64    | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Akero Therapeutics, Inc.                       | Akero Therapeutics, Inc., CVR                         | CUSIP: 009CVR044<br>LEI: 549300SI3KG74LBE2955 | Long             |  | CORP              | US        |    515954 | NS      | $340529.64    | 0.00%             |  |  |  | No            |                  3 | On Loan: —       |
| Definium Therapeutics, Inc.                    | Definium Therapeutics, Inc.                           | CUSIP: 24477V105<br>LEI: 549300QY8KN1O6RPFJ13 | Long             | EC               | CORP              | CA        |    703030 | NS      | $13287267.00  | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Compass Pathways plc                           | Compass Pathways plc                                  | CUSIP: 20451W101<br>LEI: 213800N7CUZIC6QSTZ31 | Long             | EC               | CORP              | GB        |    612150 | NS      | $3385189.50   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Tyra Biosciences, Inc.                         | Tyra Biosciences, Inc.                                | CUSIP: 90240B106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    272474 | NS      | $10435754.20  | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Moderna, Inc.                                  | Moderna, Inc.                                         | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |   2692459 | NS      | $136776917.20 | 1.68%             |  |  |  | No            |                  1 | On Loan: —       |
| AtaiBeckley, Inc.                              | AtaiBeckley, Inc.                                     | CUSIP: 04650F101<br>LEI: 529900HOVZ0MXOBQ5Y47 | Long             | EC               | CORP              | US        |   2160067 | NS      | $7646637.18   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Maze Therapeutics, Inc.                        | Maze Therapeutics, Inc.                               | CUSIP: 578784100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    197936 | NS      | $5908389.60   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Tenaya Therapeutics, Inc.                      | Tenaya Therapeutics, Inc.                             | CUSIP: 87990A106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1200002 | NS      | $830881.38    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Alkermes plc                                   | Alkermes plc                                          | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | IE        |   1216662 | NS      | $43021168.32  | 0.53%             |  |  |  | No            |                  1 | On Loan: —       |
| Veracyte, Inc.                                 | Veracyte, Inc.                                        | CUSIP: 92337F107<br>LEI: 529900ESWZRHXOW27Z37 | Long             | EC               | CORP              | US        |    579343 | NS      | $18660638.03  | 0.23%             |  |  |  | No            |                  1 | On Loan: —       |
| N/A                                            | E-Mini Health Care Select Sector Index                | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |        53 | NC      | $-73746.73    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Anavex Life Sciences Corp.                     | Anavex Life Sciences Corp.                            | CUSIP: 032797300<br>LEI: 549300K1I5L8COCQ8W36 | Long             | EC               | CORP              | US        |    668447 | NS      | $2052132.29   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Akouos, Inc.                                   | Akouos, Inc., CVR                                     | CUSIP: 009CVR036<br>LEI: N/A                  | Long             |  | CORP              | US        |    157087 | NS      | $1.57         | 0.00%             |  |  |  | No            |                  3 | On Loan: —       |
| Terns Pharmaceuticals, Inc.                    | Terns Pharmaceuticals, Inc.                           | CUSIP: 880881107<br>LEI: 254900S1ZDQMF4MYP709 | Long             | EC               | CORP              | US        |    713848 | NS      | $37634066.56  | 0.46%             |  |  |  | No            |                  1 | On Loan: —       |
| OmniAb Operations, Inc.                        | OmniAb, Inc., 12.50 Earnout Shares                    | CUSIP: 68218J202<br>LEI: N/A                  | Long             |  | CORP              | US        |     46839 | NS      | $0.47         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Neumora Therapeutics, Inc.                     | Neumora Therapeutics, Inc.                            | CUSIP: 640979100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    421430 | NS      | $821788.50    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| GH Research plc                                | GH Research plc                                       | CUSIP: N/A<br>LEI: 875500HKJS7QQG6EWH62       | Long             | EC               | CORP              | IE        |    334162 | NS      | $4698317.72   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |

### Signature

**Date Signed:** 2026-03-31

**Name of Applicant:** iShares Trust

**Signature:** Chuck Pulsfort

**Name of Signer:** Chuck Pulsfort

**Title:** Assistant Treasurer