# EDGAR Filing Document

**Accession Number:** 0001771910
**File Stem:** 0000950103-25-012514
**Filing Date:** 2025-9
**Character Count:** 41165
**Document Hash:** 8587abdaa3e250482a5495ccc91b2cc2
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000950103-25-012514.hdr.sgml**: 20250930

**ACCESSION NUMBER**: 0000950103-25-012514

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 40

**CONFORMED PERIOD OF REPORT**: 20250930

**ITEM INFORMATION**: Regulation FD Disclosure

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20250930

**DATE AS OF CHANGE**: 20250930

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** ADC Therapeutics SA
- **CENTRAL INDEX KEY:** 0001771910
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** V8
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-39071
- **FILM NUMBER:** 251358381

**BUSINESS ADDRESS:**
- **STREET 1:** BIOPOLE
- **STREET 2:** ROUTE DE LA CORNICHE 3B
- **CITY:** EPALINGES
- **STATE:** V8
- **ZIP:** 1066
- **BUSINESS PHONE:** 41 21 653 02 00

**MAIL ADDRESS:**
- **STREET 1:** BIOPOLE
- **STREET 2:** ROUTE DE LA CORNICHE 3B
- **CITY:** EPALINGES
- **STATE:** V8
- **ZIP:** 1066

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**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**FORM 8-K**

**CURRENT REPORT**

**Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934** 

Date of Report (Date of Earliest Event Reported): September 30, 2025

**ADC Therapeutics SA**

(Exact Name of Registrant as Specified in Its Charter)

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| | | |
|:---|:---|:---|
| **Switzerland**<br>(State or Other Jurisdiction of Incorporation) | **001-39071**<br>(Commission File Number) | **N/A**<br>(IRS Employer Identification Number)<br>|

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| | |
|:---|:---|
| **Biopôle**<br>**Route de la Corniche 3B**<br>**1066 Epalinges**<br>**Switzerland**<br>(Address of Principal Executive Offices) (Zip Code) | **+41 21 653 02 00**<br>(Registrant's Telephone Number)<br>|

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**N/A**

(Former Name or Former Address, if Changed Since Last Report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Exchange Act:

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| | | |
|:---|:---|:---|
| **Title of Each Class** | **Trading Symbol** | **Name of Each Exchange on Which Registered** |
| Common Shares, par value CHF 0.08 per share | ADCT | New York Stock Exchange |

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Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 C.F.R. §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 C.F.R. §240.12b-2). Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

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**Item 7.01. Regulation FD Disclosure.**

On September 30, 2025, ADC Therapeutics SA (the "Company") made available an updated corporate presentation. A copy of the corporate presentation is attached as Exhibit 99.1 to this Current Report on Form 8-K and incorporated by reference herein.

The information contained in these Items and Exhibit 99.1 shall not be deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing.

**Item 9.01. Financial Statements and Exhibits.**

(d) Exhibits.

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| | |
|:---|:---|
| **Exhibit Number** | **Description** |
| [99.1](dp235214_ex9901.htm) | [Corporate presentation](dp235214_ex9901.htm) |
| 104 | Cover Page Interactive Data File (embedded within the Inline XBRL document) |

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**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

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| | | |
|:---|:---|:---|
|  | **ADC Therapeutics SA** | **ADC Therapeutics SA** |
| Date: September 30, 2025 |  |  |
|  | By: | /s/ Peter J. Graham |
|  | Name: | Peter J. Graham |
|  | Title: | Chief Legal Officer |

---

## Exhibit 99.1

**Exhibit 99.1**

![](ex9901_001.jpg)

Corporate Presentation October 2025

![](ex9901_002.jpg)

Forward - Looking Statements This presentation and any accompanying oral presentation have been prepared by ADC Therapeutics SA ("ADC Therapeutics", "we" or "us") for informational purposes only and not for any other purpose. Nothing contained in this presentation is, or should be construed as, a recommendation, promise or representation by the presenter or ADC Therapeutics or any officer, director, employee, agent or advisor of ADC Therapeutics. This presentation does not purport to be all - inclusive or to contain all of the information you may desire. Information provided in this presentation and any accompanying oral presentation speak only as of the date hereof. This presentation contains forward - looking statements within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. In some cases you can identify forward - looking statements by terminology such as "may", "will", "should", "would", "expect", "intend", "plan", "anticipate", "believe", "estimate", "predict", "potential", "seem", "seek", "future", "continue", or "appear" or the negative of these terms or similar expressions, although not all forward - looking statements contain these identifying words. Forward - looking statements are subject to certain risks and uncertainties that can cause actual results to differ materially from those described. Factors that may cause such differences include, but are not limited to: the success of the Company's strategic restructuring plan; changes in estimated costs associated with the restructuring plan including the workforce reduction and planned closure of the UK facility; the expected cash runway into 2028 which assumes use of minimum liquidity amount required to be maintained under its loan agreement covenants; whether future LOTIS - 7 clinical trial results will be consistent with or different from the LOTIS - 7 data presented at EHA and ICML and future compendia and regulatory strategy and opportunity; the timing of the PFS events for LOTIS - 5 and topline publication and the results of the trial and full FDA approval; the Company's ability to grow ZYNLONTA® revenue in the United States; the ability of our partners to commercialize ZYNLONTA® in foreign markets, the timing and amount of future revenue and payments to us from such partnerships and their ability to obtain regulatory approval for ZYNLONTA® in foreign jurisdictions; the timing and results of the Company's or its partners' research and development projects or clinical trials including LOTIS 5 and 7, as well as early pre - clinical research for our exatecan - based ADC targeting PSMA; the timing and results of investigator - initiated trials including those studying FL and MZL and the potential regulatory and/or compendia strategy and the future opportunity; the timing and outcome of regulatory submissions for the Company's products or product candidates; actions by the FDA or foreign regulatory authorities; projected peak revenue and expenses; the Company's indebtedness, including Healthcare Royalty Management and Blue Owl and Oaktree facilities, and the restrictions imposed on the Company's activities by such indebtedness, the ability to comply with the terms of the various agreements and repay such indebtedness and the significant cash required to service such indebtedness; and the Company's ability to obtain financial and other resources for its research, development, clinical, and commercial activities; and the uncertainties of international trade policies, including tariffs, sanctions and trade barriers and potential impact they may have on our business, financial condition, and results of operations. Additional information concerning these and other factors that may cause actual results to differ materially from those anticipated in the forward - looking statements is contained in the "Risk Factors" section of the Company's Annual Report on Form 10 - K and in the Company's other periodic and current reports and filings with the U.S. Securities and Exchange Commission. These statements involve known and unknown risks, uncertainties and other factors that may cause actual results, performance, achievements or prospects to be materially different from any future results, performance, achievements or prospects expressed in or implied by such forward - looking statements. The Company cautions investors not to place undue reliance on the forward - looking statements contained in this document. Forward - looking statements are based on our management's beliefs and assumptions and on information currently available to our management. No assurance can be given that such future results will be achieved. Such forward - looking statements contained in this presentation speak only as of the date of this presentation. The Company expressly disclaim any obligation or undertaking to update these forward - looking statements contained in this presentation to reflect any change in our expectations or any change in events, conditions, or circumstances on which such statements are based unless required to do so by applicable law. No representations or warranties (expressed or implied) are made about the accuracy of any such forward - looking statements. Certain information contained in this presentation relates to or is based on studies, publications, surveys, and other data derived from third - party sources and our own internal estimates and research. While we believe these third - party sources to be reliable as of the date of this presentation, we have not independently verified, and we make no representation as to the adequacy, fairness, accuracy or completeness of, any information obtained from third - party sources. In addition, all of the market data included in this presentation involve a number of assumptions and limitations, and there can be no guarantee as to the accuracy or reliability of such assumptions. Finally, although we believe our own internal research is reliable, such research has not been verified by any independent source. This presentation shall not constitute an offer to sell or the solicitation of an offer to buy securities, nor shall there be any sales of securities in any state jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. 2

![](ex9901_003.jpg)

3 A Pioneer and Leader in ADCs Corporate Capability Pipeline Commercial - stage pioneer in the field of ADCs, with specialized capabilities from clinical through commercialization Seeking expansion of FDA - approved ZYNLONTA® while pursuing early - stage PSMA - targeting ADC towards IND Delivering on our strategy supported by an accomplished and multidisciplinary team and with cash runway expected into 2028

![](ex9901_004.jpg)

4 DLBCL: Diffuse Large B - Cell Lymphoma; FL: Follicular Lymphoma; MZL: Marginal Zone Lymphoma; NSCLC: Non - Small Cell Lung Cancer; ALL: Acute Lymphoblastic Leukemia Focused Portfolio with ZYNLONTA and PSMA - targeting ADC ZYNLONTA → Currently commercialized program in 3L+ DLBCL is self - funded → Potential expansion into earlier lines of therapy and with new indications - LOTIS - 5: rituximab combination - LOTIS - 7: bispecific combinations - Indolent lymphomas (FL and MZL) PSMA - targeting ADC → Advancing IND - enabling activities for next - generation ADC candidate - Differentiated exatecan - based payload with novel hydrophilic linker - Seeking research collaborations

![](ex9901_005.jpg)

5 Please visit ZYNLONTA.com for complete prescribing information including indication, warnings and precautions. → ZYNLONTA is a CD19 - directed ADC indicated as monotherapy for the treatment of adult patients with relapsed or refractory large B - cell lymphoma after two or more lines of systemic therapy → Rapid, deep, and durable efficacy – Median time to CR 1.5 months – 48.3% ORR and 24.8% CR – Median duration of response not yet reached for patients in CR at 2 - year follow - up → Manageable safety profile – No CRS or ICANS and no cumulative irreversible toxicities → Accessibility – Simple Q3W dosing with no REMS or inpatient stay requirements ZYNLONTA is Ideally Suited Across Care Settings for Patients with r/r DLBCL

![](ex9901_006.jpg)

6 Advancing ZYNLONTA Development Into 2L+ B - Cell Lymphomas Current Approval Current Development Areas DLBCL F L M ZL 1L 2L+ 3L+ ZYNLONTA+R ZYNLONTA ZYNLONTA+R ZYNLONTA ZYNLONTA Potential Benefit In Indolent Lymphomas LO T I S - 5 LO T I S - 7 Potential To Move Into 2L+ DLBCL ZYNLONTA + rituximab 1 (N=20) LOTIS - 5 Overall Response Rate Complete Response Rate ~80% ~50% ZYNLONTA + rituximab 3 (N=39) High - risk r/r FL Overall Response Rate Complete Response Rate ~97% ~77% ZYNLONTA + glofitamab 2 (N=30) LOTIS - 7 ~93 % ~87% ZYNLONTA 4 (N=27) r/r MZL ~85 % ~69% 1 Safety run - in study as detailed in SOHO 2023 poster presentation 2 As detailed in EHA 2025 poster presentation scheduled for June 14, 2025 3 As detailed in ASH 2024 oral presentation; Alderuccio, PJ. Loncastuximab tesirine with rituximab in patients with relapsed or refractory follicular lymphoma: a single centre, single arm Phase 2 trial. The Lancet Haematology. January 2025; Volume 12 (Issue 1): E23 - E34. 4 As detailed at ICML in June 2025

![](ex9901_007.jpg)

7 Broadly accessible therapies ~75% 2L ~12k patients 3L+ ~6k patients Two Distinct Segments in r/r DLB CL Treatment Options 2L+ treatment choice based on efficacy, safety and accessibility in context of individual patient need » Complex therapies with unique patient management and infrastructure requirements » Broadly accessible outpatient therapies Complex therapies ~25% ~20% CAR T ~5% SCT Complex therapies ~60% 35% Bispecific - mono ~20% CAR T ~5% SCT Current r/r DLBCL U.S. Market ADCs, mAbs, Chemo / other Broadly accessible therapies ~40% ADCs, mAbs, Chemo / other ~10% ZYNLONTA Based on internal market research conducted July to August 2024 (n=160 US Hem/Oncs), and glofitamab ODAC briefing book

![](ex9901_008.jpg)

8 1. LOTIS - 7 (loncastuximab + glofitamab) – EHA 2025 poster presentation - 87% CR as of data cutoff of April 14, 2025; 2. Yescarta (axi - cel) – USPI, ZUMA - 7 study – 65% CR; 3. Breyanzi (liso - cel) – USPI, TRANSFORM study – 66% CR; 4. Columvi (glofitamab) + GEMOX – STARGLO study, Lancet 2024 – 59% CR; 5. Mosunetuzumab + Polatuzumab – Phase 1/2b ASH Presentation 2024 – 58% CR; 6. Epkinly (Epcoritamab) + GEMOX – EPCORE NHL - 2 study ASH Poster 2024 – 61% CR; 7. Epkinly (epcoritamab) – USPI, EPCORE - NHL - 1 study – 38% CR; 8. Columvi (Glofitamab) – USPI, Study NP30179 – 43% CR; 9. LOTIS - 5 (loncastuximab + Rituximab) – SOHO 2023 safety run - in poster – 50% CR; 10. Adcetris (Brentuximab) + R2 – USPI, ECHELON - 3 study, JCO 2025 – 45% CR; 11. Polatuzumab + BR – USPI, Study GO29365 – 40% CR; 12. Monjuvi (Tafasitamab + Lenalidomide) – USPI, L - MIND study – 37% CR; 13. LOTIS - 2 (loncastuximab) – 2 year follow up, LOTIS - 2 study – 25% CR; 14. R - GEMOX – control arm of STARGLO study, Lancet 2024 – 25% CR Note: No head - to - head trials have been conducted among the results shown. Comparing the results from different trials may be unreliable due to different protocol designs, trial design, patient selection and populations, number of patients, trial endpoints, trial objectives and other parameters that may not be the same between trials. ZYNLONTA Has Potential to Disrupt r/r DLBCL Market and Unlock Significant Growth Opportunity in Both Segments Emerging data - not FDA approved 100 - CAR T - cell therapy 2, 3 ~65% Bispecific combinations Glofit + GEMOX 4 Mosun + Pola 5 Epco + GEMOX 6 ~60% 87% LOTIS - 7 (Lonca + Glofit) 1 ~40% Bispecific - mono 7, 8 Complete Response Rate (%) 60 - ZYNLONTA combinations have the potential to unlock significant growth through: → Doubling the addressable patient population (2L) → Capturing higher market share with leading efficacy → Increasing average duration of therapy (3 cycles with mono to 5 - 6 with combo) 50 - 40 - 0 - 0 - 50% LOTIS - 5 (Lonca + R) 9 ADCs / mAbs Brentuximab + R2 10 Pola + BR 11 Tafa + Len 12 ~40% 25% LOTIS - 2 (Lonca - mono) 13 25% R - GEMOX (R - based Chemo) 14 Complete Response Rate (%) 25 - 40 - Complex therapies (CAR T - cell therapy, Bispecifics) Broadly accessible therapies (ADCs, mAbs, Chemo / other)

![](ex9901_009.jpg)

9 LOTIS - 7 (ZYNLONTA + glofitamab) Opportunity LOTIS - 5 (ZYNLONTA + rituximab) Opportunity Illustrative depiction of potential market share based on internal market research Conducted July to August 2024 (n=160 US Hem/Oncs) ZYNLONTA Combinations Potentially Raising the Bar → We believe LOTIS - 5 has the potential to be the leading regimen for patients who will not receive complex therapies → High CR rate among broadly accessible therapies (ADCs, mAbs, chemo/other) in r/r DLBCL → Manageable safety with reversible toxicities Compl e x Therapies → We believe LOTIS - 7 has the potential to be the leading bispecific combination regimen for patients with access to complex therapies → Leading CR rate that rivals CAR T - cell therapy with a manageable toxicity profile and improved accessibility → LOTIS - 7 provides a unique combination for r/r DLBCL without repeat exposure to polatuzumab and chemo 50% CR Broadly Accessible Therapies on Efficacy in r/r DLBCL 87% CR

![](ex9901_010.jpg)

10 LOTIS - 5: Phase 3 Confirmatory Trial of ZYNLONTA in Combination with Rituximab in 2L+ DLBCL Initial data demonstrates that this combination has the potential to provide competitive 2L+ efficacy with a favorable safety profile allowing broad accessibility Status and Next Steps → Full enrollment completed in 2024 → After the prespecified number of PFS events is reached and data are available, the Company expects to provide topline data in 1H 2026 → sBLA submission and potential approval to follow LOTIS - 5 Overview → Patient Population: 420 randomized 1:1 2L+ DLBCL patients, ASCT ineligible → Primary endpoint: PFS; Secondary endpoints include OS; ORR; CRR; DoR; frequency and severity of adverse events → Initial data: 20 patient safety run - in, resulting in 80% ORR and 50% CR (mDOR not reached for CR), with no new safety signals 1 Treatment Period Follow - Up Period End of Treatment Randomized 1:1 N = 420 Loncastuximab tesirine 0.15 mg/kg + rituximab 375 mg/m 2 Q3W for 2 cycles Loncastuximab tesirine 0.075 mg/kg + rituximab 375 mg/m 2 Q3W for up to 6 additional cycles Lonca (0.15 mg/kg) + rituximab (375 mg/m 2) Q3W for 2 cycles Lonca (0.075 mg/kg) + rituximab (375 mg/m 2) Q3W for up to 6 additional cycles R - GemOx: rituximab 375 mg/m 2 + gemcitabine 1000 mg/m 2 + oxaliplatin 100 mg/m 2 Q2W for up to 8 cycles For both parts of the study, irrespective of disease status, patients will be followed for up to 4 years after EOT until withdrawal of consent, loss to follow - up, or death — whichever occurs first Nonrandomized Safety Run - in N = 20 1 – Initial data from SOHO 2023 poster presentation; updated data from EHA 2025 poster presentation

![](ex9901_011.jpg)

11 LOTIS - 7 Combination Rationale and Biological Hypothesis Potent, single agent drugs with distinct and complementary MOAs ZYNLONTA ANTI - CD19 ADC GLOFITAMAB ANTI - CD20/CD3 T - Cell engaging bispecific antibody EFFICACY ▪ Expected to have additive or synergistic efficacy SAFETY ▪ No overlapping non - hematologic toxicities expected to yield manageable safety profile ▪ Potentially lower CRS rates/grades given ZYNLONTA use prior to glofitamab may debulk the tumors and reduce peripheral B cells

![](ex9901_012.jpg)

12 END OF TREATMENT ZYNLONTA IV (120 or 150 µg/kg3) + glofitamab IV Q3W Enrollment began Apr 2024 Escalating doses of ZYNLONTA IV + mosun SC Q3W2 Enrollment began July 2023 Escalating doses of ZYNLONTA IV + glofitamab IV Q3W1 Enrollment began July 2023 SCREENING PERIOD TREATMENT PERIOD (≤28 DAYS) (CYCLES OF 21 DAYS) r/r DLBCL, FL, MZL for both arms r/r LBCL Part 1 3+3 Dose escalation (ZYNLONTA 90, 120, and 150 μ g/kg) Part 2 Dose exp a nsion Study Population → Relapsed or Refractory B - NHL patients, ECOG PS 0 – 2, and have received: – Part 1: >2 systemic treatment regimens – Part 2: >1 systemic treatment regimens → Prior autologous SCT or CAR - T (>100 days) is allowed → Measurable disease per 2014 Lugano Classification → Excludes patients with clinically significant 3rd space fluid accumulation Endpoints → Primary: Safety and tolerability; MTD and/or RD → Secondary: – Efficacy: ORR, DOR, CRR, PFS, RFS, OS – Pharmacokinetics and Immunogenicity Trial Status → Dose escalation complete with no DLTs, no high - grade CRS or ICANS and early signs of anti - tumor activity → Dose expansion of 40 patients completed in ZYNLONTA (120 or 150 µg/kg) + glofitamab → 150 µg/kg dose selected; expanding to 100 patients ZYNLONTA + Glofitamab Treatment Sequence Cycle 1 Cycle 9 to Cycle 12 Day 1 Ho s p ita l i z at i o n required Glofit Cycle 2 to Cycle 8 Day 1: both agents on same day Lo nc a Glofit 1 to 1.5 hrs in - between Day 15 Glofit Day 2 Day 8 Lo nc a Glofit Day 1 Gpt Obinutuzumab pretreatment 1000mg on C1D1; ZYNLONTA administered on C1D2; administration of 1st and 2nd step - up dose(s) of IV glofitamab (2.5mg on C1D8 & 10mg on C1D15); ZYNLONTA plus glofitamab 30mg on C2D1 and beyond (reduce ZYNLONTA to 75 ug/kg at C3 if starting dose is 120 ug/kg or higher) ZYNLONTA plus subcutaneous mosunetuzumab 1st step - up dose of 5 mg on C1D1, followed by mosunetuzumab 2nd step - up & target dose of 45 mg for C1D8 & C1D15; ZYNLONTA plus 45mg of subcutaneous mosunetuzumab on C2D1 and beyond (reduce ZYNLONTA to 75 μ g/kg at C3 if starting dose is 120 ug/kg or higher) ZYNLONTA dose reduced to 75 μ g/kg at C3 LOTIS - 7: Phase 1b Trial of ZYNLONTA in Combination with Glofitamab

![](ex9901_013.jpg)

13 LOTIS - 7 Phase 1b Trial: Baseline Patient Characteristics r/r Large B - Cell Lymphoma Treated Population (N=41) as of data cutoff of April 14, 2025 All patients enrolled in US & Europe with majority in US N=41 150 µg/kg N=21 120 µg/kg N=20 IPI Score 19 (46.3%) 10 (47.6%) 9 (45%) 0/1/2 22 (53.7%) 11 (52.4%) 11 (55%) 3/4/5 21 (51.2%) 10 (47.6%) 11 (55%) LDH Level High Ann Arbor stage 6 (14.6%) 3 (14.3%) 3 (15%) I/II 35 (85.3%) 18 (85.7%) 17 (85%) III/IV 4 (9.8%) 2 (9.5%) 2 (10%) Bulky Disease (≥10 cm) 2 (1,5) 2 (1,5) 2 (1,4) Median prior lines of therapy (range) Number of prior lines of therapy 20 (48.8%) 10 (47.6%) 10 (50%) 1 21 (51.2%) 11 (52.4%) 10 (50%) ≥ 2 4 (9.8%) 1 (4.8%) 3 (15%) Prior Stem Cell Transplant 8 (19.5%) 4 (19%) 4 (20%) Prior CAR - T Therapy 21 (51.2%) 13 (61.9%) 8 (40%) Refractory to primary therapy 20 (48.8%) 13 (61.9%) 7 (35%) Refractory to last prior therapy N=41 150 µg/kg N=21 120 µg/kg N=20 71 (26, 85) 74 (26, 85) 70 (50, 82) Median age [years (range)] 23 (56.1%) 12 (57.1%) 11 (55%) Male ECOG Performance Status 23 (56.1%) 14 (66.7%) 9 (45%) 0 17 (41.5%) 7 (33.3%) 10 (50%) 1 1 (2.4%) 0 1 (5%) 2 Large B - Cell Lymphoma Histology 30 (73.2%) 17 (81%) 13 (65%) de novo DLBCL 4 (9.8%) 2 (9.5%) 2 (10%) trFL 6 (14.6%) 2 (9.5%) 4 (20%) HGBCL 1 (2.4%) 0 1 (5%) FL Grade 3b DLBCL Subtype 21 (51.2%) 11 (52.4%) 10 (50%) GCB 13 (31.7%) 8 (38.1%) 5 (25%) non - GCB 8 (19.5%) 5 (23.8%) 3 (15%) Double/Triple hit LBCL = large B - cell lymphoma, DLBCL= diffuse large B - cell lymphoma, HGBCL= high grade B - cell lymphoma, NOS = not otherwise specified, trFL= transformed follicular lymphoma, GCB, germinal center B - cell Data cutoff: 14Apr2025 Note: Data extracted from live clinical database. Data is subject to change.

![](ex9901_014.jpg)

14 LOTIS - 7 Phase 1b Trial: Safety Summary r/r Large B - Cell Lymphoma Treated Population (N=41) as of data cutoff of April 14, 2025 a As per Investigator reported adverse events TEAE = treatment emergent adverse event; AESI = adverse event of special interest Data cutoff: 14 Apr 2025. Data extracted from live clinical database. Data is subject to change. All n = 41 150 µg/kg n=21 120 µg/kg n=20 23 (56.1%) 12 (57.1%) 11 (55%) Grade 3/4 TEAEs (> 5% of patients) a 10 (24.4%) 6 (28.6%) 4 (20%) Neutropenia 4 (9.8%) 3 (14.3%) 1 (5%) Anemia 3 (7.3%) 1 (4.8%) 2 (10%) AST increased 3 (7.3%) 2 (9.5%) 1 (5%) GGT increase 3 (7.3%) 1 (4.8%) 2 (10%) Thrombocytopenia Grade 3/4 AESI (all patients) a 1 (2.4%) 1 (4.8%) 0 Febrile neutropenia 3 (7.3%) 1 (4.8%) 2 (10%) Thrombocytopenia 3 (7.3%) 2 (9.5%) 1 (5%) GGT increase 2 (4.9%) 1 (4.8%) 1 (5%) Generalized oedema 1 (2.4%) 0 1 (5%) Rash 1 (2.4%) 1 (4.8%) 0 Photosensitivity reaction 1 (2.4%) 0 1 (5%) Sepsis 1 (2.4%) 0 1 (5%) Upper respiratory infection 1 (2.4%) 0 1 (5%) Pneumonia 20 (48.8%) 9 (42.9%) 11 (55%) Serious TEAE

![](ex9901_015.jpg)

15 LOTIS - 7 Phase 1b Trial: Safety Summary r/r Large B - Cell Lymphoma Treated Population (N=41) as of data cutoff of April 14, 2025 a As per Investigator reported adverse events TEAE = treatment emergent adverse event; AESI = adverse event of special interest Data cutoff: 14 Apr 2025. Data extracted from live clinical database. Data is subject to change. All n = 41 150 µg/kg n=21 120 µg/kg n=20 Patients with TEAEs leading to study drug discontinuation a 3 (7.3%) 2 (9.5%) 1 (5%) TEAE leading to loncastuximab discontinuation only 1 (2.4%) 0 1 (5%) Pericardial effusion 1 (2.4%) 1 (4.8%) 0 Generalized oedema and GGT increased 1 (2.4%) 1 (4.8%) 0 Pleural effusion and erythema 3 (7.3%) 3 (14.3%) 0 TEAE leading to glofitamab discontinuation only 1 (2.4%) 1 (4.8%) 0 ICANS 1 (2.4%) 1 (4.8%) 0 Polyneuropathy 1 (2.4%) 1 (4.8%) 0 Febrile Neutropenia

![](ex9901_016.jpg)

16 LOTIS - 7 Phase 1b Trial: CRS/ICANS Profile & Management r/r Large B - Cell Lymphoma Treated Population (N=41) as of data cutoff of April 14, 2025 a Number of patients who experienced at least 1 event per ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells; worst grade reported if applicable Data Cutoff 14 Apr 2025. Note: Data extracted from live clinical database. Data is subject to change. All n = 41 150 µg/kg n=21 120 µg/kg n=20 Cytokine Release Syndrome a 16 (39.0%) 5 (23.8%) 11 (55%) Any grade 12 (29.3%) 5 (23.8%) 7 (35%) Grade 1 3 (7.3%) 0 3 (15%) Grade 2 1 (2.4%) 0 1 (5%) Grade 3 0 0 0 Grade 4/5 ICANS a 3 (7.3%) 1 (4.8%) 2 (10%) Any grade 1 (2.4%) 0 1 (5%) Grade 1 2 (4.9%) 1 (4.8%) 1 (5%) Grade 2 0 0 0 Grade > 3 • Grade 1 and 2 CRS cases managed with tocilizumab, corticosteroids, acetaminophen, and/or fluid bolus, without ICU admittance or pressor support • Grade 3 CRS case managed with tocilizumab, acetaminophen, dexamethasone, norepinephrine. ICU admittance • All patients with ICANS had complete resolution of symptoms • Two patients resumed treatment and ultimately achieved a CR • One patient elected to discontinue treatment • ICANS managed primarily with corticosteroids

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17 Total 150 µg/kg 120 µg/kg % n=30 % n=15 % n=15 93.3% 28 93.3% 14 93.3% 14 ORR (CR + PR) 86.7% 26 86.7% 13 86.7% 13 Complete Response (CR) 6.7% 2 6.7% 1 6.7% 1 Partial Response (PR) 3.3% 1 0% 0 6.7% 1 Stable Disease 3.3% 1 6.7% 1 0% 0 Progressive Disease As of data cut off 14 Apr 2025. Note: Data extracted from live clinical database. Data is subject to change. LOTIS - 7 Phase 1b Trial: Overall Response Rate (ORR) r/r Large B - Cell Lymphoma Efficacy Evaluable Population (N=30) as of April 14, 2025

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18 ir che ed assess nt a F st s dul m e t 6 ks wee tud ura S y D ti a on (D ys) 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16\* 17\* 18\* 19\* 20\* 21 22 23 24 25 26 27 28 28 30 31 32 33 34 35 36\* 37\* 38\* 39\* 40\* 41\* Glofit + Lonca 150 µg/kg As of data cut off 14 April 2025 Data extracted from live clinical database. Data is subject to change. LOTIS - 7 Phase 1b Trial: Efficacy Over Time r/r Large B - Cell Lymphoma Treated Population (N=41) as of April 14, 2025 Subject Number Glofit + Lonca 120 µg/kg » Most responses observed at initial assessment » 12 patients converted from SD (1) or PR (11) to CR over time » 25/26 CRs remain in CR as of the data cut - off • Median time to CR in 120 µg/kg = 80 days • Median time to CR in 150 µg/kg = 42 days \*Not Yet Efficacy Evaluable Patients: 10 patients have not yet reached the 6 - week assessment; 1 patient (37) withdrew prior to any assessment

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19 ^ Data do not include all 2L MZL regimens such as B+O, R - CHOP, R - CVP, or B - R because inclusion based on either front - line data or studies in mixed histologies; 1 . MAGNOLIA Trial (single arm, multicenter ph 2; n = 68) – Best Response; 2. ACE - LY - 003 study (part 2 of multicenter, ph 1/2b; n = 43) – Best Response; 3. AUGMENT study (randomized ph3 of R2 vs. R; total n = 358, total MZL n = 63, R2 MZL n = 31, R mono MZL n = 32) – Best Response; 4. BRUIN study (ph 1/2 of pirtobrutinib in CLL/SLL and NHL, total estimated n = 860, total MZL n = 36) - . 5. Clarivate DRG (2022); 6. Global Data (2017); 7. Cerner Enviza CancerMPact (2023), distribution by line of therapy is based on the incident, drug - treated population. \*This data reflects abstract data published at ICML on June 15, 2025 followed by a poster on June 18, 2025 based on the same data cutoff of February 10, 2025 Note: No head - to - head trials have been conducted among the results shown. Comparing the results from different trials may be unreliable due to different protocol designs, trial design, patient selection and populations, number of patients, trial endpoints, trial objectives and other parameters that may not be the same between trials. ZYNLONTA Phase 2 IIT Data Showed 69.2% CR Rate in r/r MZL ORR % 65% Len + Rituximab (R2) 3 53% Acalabrutinib 2 CR 0 - 0 - % 60 - 68% Zanubrutinib 1 60 - 40 - 40 - 20 - 20 - 50% Pirtobrutinib 4 prevalence 7 durable responses, high unmet medical need remains with <30% CR for 2L NCCN preferred treatments 1 - 4 ~15 K 2L+ MZL patients Key: 1L 2L 3L+ Current FDA Approved / 2L NCCN Preferred Regimens with r/r MZL Data 80 - 80 - FDA Approved / NCCN Preferred^ N = 63 – 68 NCCN Preferred^ Only N = 36 – 46 r/r MZL Patient Population → Estimated 3 – 4k 2L+ MZL patients are drug - treated in the US annually 5 - 7 ; despite patients achieving U.S. 5 - year University of Miami phase 2 IIT in r/r MZL\* → Highlights of ICML 2025 abstract by Dr. Izidore Lossos on study of ZYNLONTA in patients with r/r MZL: – N = 27 patients enrolled (as of Feb 10, 2025) from Univ of Miami Sylvester Comprehensive Cancer Center & City of Hope, with 26 efficacy evaluable – ORR of 84.6% (22 of 26); CR of 69.2% (18 of 26) • POD24 patients (N = 13): 61.5% CR • CR maintained in 17 out of 18 CR patients, with longest duration of CR of 27 months from the start of treatment – Safety consistent with known profile of ZYNLONTA • Adverse events (AE) were most commonly grade 1 or 2. Grade 3 and 4 AEs were observed in 16 and 2 patients, respectively, including neutropenia, RSV lung infection, and hyponatremia (with 2 AEs in the same patient) • Three patients needed dose reduction and one patient discontinued treatment after cycle 4 due to cholestatic hepatitis that fully recovered Next Steps → The study was recently expanded to Emory Winship Cancer Institute and Vanderbilt - Ingrim Cancer Center to accelerate enrollment to 50 r/r MZL patients → ADCT plans to potentially pursue regulatory pathway and compendia in parallel as soon as sufficient data are available 29% Len + Rituximab (R2) 3 26% Zanubrutinib 1 13% Acalabrutinib 2 3% Pirtobrutinib 4

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20 ZYNLONTA + Rituximab Phase 2 IIT Data Show 77% CR Rate in r/r FL University of Miami phase 2 IIT in 2L+ FL ASH 2024 presentation & Lancet Haem publication highlights 11 U.S. 5 - year Prevalenc e 1 ~21k 2L+ FL patients Key: 1L 2L 3L+ Next Steps → University of Miami expanding the trial by increasing target enrollment to 100 high - risk r/r FL patients and opening the study at additional US cancer research centers → ADCT plans to potentially pursue regulatory pathway and compendia in parallel as soon as sufficient data are available 2L+ FL Patient Population → Estimated 6k 2L+ FL patients are drug - treated in the US annually 1 , of which ~20% relapse within the first 24 months of frontline therapy (POD24) and are characterized by an unfavorable prognosis 2 77% 85% 20% 15% Total (n =39) CR PO D2 4 (n=20) PR 97% 100% → N = 39 patients (all of which were evaluated for safety and for efficacy) → Best ORR of 97.4% (n=38); CR rate of 76.9% (n=30) → After median follow - up of 15.6 months, median PFS was not reached, and the 12 - month PFS was 94.6% → Safety consistent with known profile of ZYNLONTA – The most common TEAEs were hyperglycemia (n=17; 43.6%), increased alkaline phosphatase (n=16; 41%) and neutropenia, fatigue and increased aspartate aminotransferase and alanine aminotransferase (n=15; 38.5%) – The most common grade ≥3 TEAE were lymphopenia (n=8; 20.5%) followed by neutropenia (n=5; 12.9%) – No Grade 5 TEAEs occurred 2L+ FL Treatment Landscape ^Data do not include all FL FDA approved or NCCN regimens (including R - mono, Obin - mono, Len - mono, B - R, R/Obin - CHOP, or R/Obin - CVP) 1. Cerner Enviza CancerMPact (2023), distribution by line of therapy is based on the incident, drug - treated population; 2. Casulo et al., J Clin Oncol (2015), Casulo et al., Blood (2022); 3. AUGMENT study (randomized ph 3 of R 2 vs. R; total n = 358, total FL n = 295, R 2 FL n = 147, R mono FL n = 148) – Best Response; 4. GADOLIN study (randomized ph3 of B + O vs. B; total n = 396, total FL n= 321, B+O FL n = 155) – Best Response in Label; 5. GO29781 study (single - arm, ph 1/2, n = 90); 6. EPCORE NHL - 1 (single - arm, ph 1/2, n = 128); 7. ELARA (single - arm, ph 2, n = 98); 8. ZUMA - 5 (single - arm, ph 2, FL n = 123); 9. TRANSCEND - FL (single - arm, ph 2, FL n = 114); 10. GALEN study (single arm, multicenter ph 2; n = 89) – Response at end of induction; 11. Alderuccio, Lancet Haem (2024) Note: No head - to - head trials have been conducted among the results shown. Comparing the results from different trials may be unreliable due to different protocol designs, trial design, patient selection and populations, number of patients, trial endpoints, trial objectives and other parameters that may not be the same between trials. Best Response FDA Approved / NCCN^ FL N = 90 - 321 35% Len + Rituximab (R2) (2L+) 3 16% Benda + Obin (2L+) 4 CR NCCN ^ Only FL N = 89 80 - 60 - 40 - 20 - 100 - 79% Axi - cel (3L+) 8 94% Liso - cel (3L+) 9 % 0 - 80 - ORR % 60 - 40 - 20 - 79% Len + Obin (2L+) 10 79% Benda + Obin (2L+) 4 100 - 97% Liso - cel (3L+) 9 94% Axi - cel (3L+) 8 86% Tisa - cel (3L+) 7 Epcoritamab (3L+) 6 82 % 80% Mosunetuzumab (3L+) 5 80% Len + Rituximab (R2) (2L+) 3 69% Tisa - cel (3L+) 7 63% Epcoritamab (3L+) 6 60% Mosunetuzumab (3L+) 5 38% Len + Obin (2L+) 10 0 -

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21 2L+ Indolent lymphomas $100M - 200M ZYNLONTA U.S. Peak Revenue Potential of $600M - 1B $600M - 1B Peak Revenue in DLBCL & Indolent Lymphomas ZYNLONTA 2L+ ZYNLONTA plus bispecific $500M - 800M LO T I S - 7 2L+ ZYNLONTA plus rituximab $200M - 300M\* LO T I S - 5 3L+ Monotherapy CURRENT INDICATION Peak revenue projection assumes both compendia listing and regulatory approval Note: ZYNLONTA Monotherapy is FDA approved under accelerated approval; other potential indications in development \*Based on quantitative market research study of 150 physicians Note: The Company does not promote ZYNLONTA for unapproved uses

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22 Note: 1. IND enabling studies have typically averaged approximately 18 months (13 – 24 months) after selection of the candidate; NHP: Non - human primate. Developing Differentiated PSMA - Targeting ADC With a High Therapeutic Index A novel hydrophilic, highly stable, protease - cleavable linker conjugated to exatecan PSMA Enzymatic glycoprotein Target description Prostate cancer Tumor types of interest Exatecan Toxin Payload Novel, hydrophilic, protease cleavable Linker in vitro characterization in vivo efficacy NHP toxicology – Repeat - dose (Q3Wx2) Preclinical data IND - enabling Stage Company moving forward with IND - enabling activities and seeking research collaboration to advance

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23 Delivering On Our Strategy ZYNLONTA LOTIS - 7 ZYNLONTA LOTIS - 5 Engage regulatory agencies, evaluate compendia strategies INDOLENT LYMPHOMAS Upcoming Expected Milestones Generate additional data and assess regulatory and compendia strategies 2H2025 Share fuller/more mature data 2H2026 1H2027 Publication and potential LOTIS - 7 compendia Potential confirmatory approval in 2L+ DLBCL Publication and potential MZL compendia Potential completion of IND - enabling activities Assess potential partner for PSMA \* Company expects to provide updated data once the pre - specified number of PFS events is reached and data are available 1H2026 Full enrollment 100 pts in recommended dose PSMA Publication and potential LOTIS - 5 compendia Share topline results\*

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Thank You

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25 Anticipated milestones set forth in this chart are subject to further future adjustment. NTE: Non - Transplant Eligible. 1. DLBCL, FL, MZL AA: Accelerated Approval. Focused Pipeline with ZYNLONTA and PSMA - targeting ADC Phase 3 / Confirmatory Phase 2 Phase 1b Phase 1a Preclinical FDA approved (AA) Confirmatory ZYNLONTA \| Targeting CD19 LOTIS - 2 in 3L+ DLBCL LOTIS - 5 with rituximab in 2L+ NTE DLBCL LOTIS - 7 with glofitamab in r/r NHL 1 U of Miami IIT with rituximab in r/r FL U of Miami IIT single agent in r/r MZL Next - Gen ADC \| Exatecan Payload with Novel Linker PSMA

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26 Both Lonca and Glofit Have Demonstrated Durable Complete Responses as Single Agents in Heavily Pretreated 3L+ Patients LOTIS - 2 (Lonca monotherapy) 2 - Yr Follow - up Analysis 1 Glofitamab (monotherapy) 3 - Yr Follow - up Analysis 3 1. LOTIS - 2 2 - yr analysis, 2. LOTIS - 5 EHA abstract, 3. ASH 2024 oral presentation • Pre - clinical studies point to complimentary mechanisms of action that elicit immune activation of T - cell mediated anti - tumor activity that may underlie the observed Lonca+Glofit anti - tumor efficacy overall (initial responses and durability of responses) • Loncastuximab tesirine mechanism of action is immunogenic cell death via intracellular delivery to CD19 expressing tumor cells its pyrrolobenzodiazepine (PBD) warhead that exerts persistent covalent cross - linking of DNA that may contribute to the prolonged duration of CRs observed in LOTIS - 2 monotherapy LOTIS - 5 Phase 3, the mDOR for CRs (50% CRR) has not been reached after 2 years of follow - up 2 (20 - patient safety run - in) CRs remained durable following fixed - duration glofitamab treatment

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27 LOTIS - 7 Clinical Trial: Rationale for Expansion of 150 µg/kg Early safety and efficacy data support the ongoing expansion of ZYNLONTA 150 µg/kg + glofitamab in 2L+ LBCL, which has been endorsed by the study DSMC\* 150 µg/kg is the approved dose of ZYNLONTA for the treatment of adult patients with relapsed or refractory (r/r) LBCL after two or more lines of systemic therapy Safety – Manageable safety profile observed in 150 µg/kg and 120 µg/kg – Lower rate of CRS (any grade) observed at 150 µg/kg vs 120 µg/kg – No Gr 3 or higher CRS events observed in 150 µg/kg vs one Gr 3 CRS observed in 120 µg/kg Efficacy – Median time to CR in 150 µg/kg (42 days) is shorter compared to 120 µg/kg (80 days) Pharmacokinetics – Higher ZYNLONTA exposure during the first two cycles was associated with an increased predicted probability of objective response, as measured by CR at Week 6 and ORR 澥 Model - predicted response probabilities were higher at 150 µg/kg compared to 120 µg/kg \*DSMC, data safety monitoring committee ORR, overall response rate; CR, complete response; SD, stable disease; PR, partial remission; DLT, dose limiting toxicity; TEAE, treatment emergent adverse event; CRS, cytokine release syndrome; ICANS, Immune Effector Cell - Associated Neurotoxicity Syndrome. Data cutoff: 14Apr2025 Note: Data extracted from live clinical database. Data is subject to change.