# EDGAR Filing Document

**Accession Number:** 0001590144
**File Stem:** 0001590144-23-000008
**Filing Date:** 2023-2
**Character Count:** 22975
**Document Hash:** 9ec9c2e1603ed1a3218bf1cd05ee610c
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001590144-23-000008.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001590144-23-000008

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**EFFECTIVENESS DATE**: 20230214

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** PURA VIDA INVESTMENTS, LLC
- **CENTRAL INDEX KEY:** 0001590144
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-16667
- **FILM NUMBER:** 23625186

**BUSINESS ADDRESS:**
- **STREET 1:** 512 W 22ND STREET
- **STREET 2:** 7TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10011
- **BUSINESS PHONE:** 646-597-6995

**MAIL ADDRESS:**
- **STREET 1:** 512 W 22ND STREET
- **STREET 2:** 7TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10011

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2022

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** PURA VIDA INVESTMENTS LLC<br>**Address:** 512 W 22ND STREET<br>7TH FLOOR<br>NEW YORK, NY 10011

**Form 13F File Number:** 028-16667

**CRD Number (if applicable):** 000166703

**SEC File Number (if applicable):** 801-80547

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Alyssa Romano<br>**Title:** Chief Financial Officer and Chief Compliance Officer<br>**Phone:** 646-597-6995

**Signature, Place, and Date of Signing:**

Alyssa Romano  New York, NY  02-14-2023<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 194

**Form 13F Information Table Value Total:** $1937765650

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| 2SEVENTY BIO INC | COMMON STOCK | 901384107 |  | 2354765 | 251309 | SH |  | SOLE |  | 251309 | 0 | 0 |
| 89BIO INC | COM | 282559103 |  | 636500 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| AGILENT TECHNOLOGIES INC | PUT | 00846U951 |  | 4489500 | 30000 | SH | Put | SOLE |  | 30000 | 0 | 0 |
| ADMA BIOLOGICS INC | COM | 000899104 |  | 1164000 | 300000 | SH |  | SOLE |  | 300000 | 0 | 0 |
| ADAPTIVE BIOTECHNOLOGIES COR | CALL | 00650F909 |  | 5730000 | 750000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| AEGLEA BIOTHERAPEUTICS INC | COM | 00773J103 |  | 471809 | 1048697 | SH |  | SOLE |  | 1048697 | 0 | 0 |
| ALIGN TECHNOLOGY INC | CALL | 016255901 |  | 2636250 | 12500 | SH | Call | SOLE |  | 0 | 0 | 0 |
| ALKERMES PLC | SHS | G01767105 |  | 1306500 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| ALNYLAM PHARMACEUTICALS INC | CALL | 02043Q907 |  | 15542310 | 65400 | SH | Call | SOLE |  | 0 | 0 | 0 |
| ALNYLAM PHARMACEUTICALS INC | PUT | 02043Q957 |  | 7129500 | 30000 | SH | Put | SOLE |  | 30000 | 0 | 0 |
| ALPINE IMMUNE SCIENCES INC | COM | 02083G100 |  | 227291 | 30924 | SH |  | SOLE |  | 30924 | 0 | 0 |
| ANNEXON INC | COM | 03589W102 |  | 1565135 | 302734 | SH |  | SOLE |  | 302734 | 0 | 0 |
| APELLIS PHARMACEUTICALS INC | CALL | 03753U906 |  | 10342000 | 200000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| APPLIED THERAPEUTICS INC | COM | 03828A101 |  | 77257 | 101654 | SH |  | SOLE |  | 101654 | 0 | 0 |
| APYX MEDICAL CORPORATION | CALL | 03837C906 |  | 1965600 | 840000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| APYX MEDICAL CORPORATION | COM | 03837C106 |  | 1421690 | 607560 | SH |  | SOLE |  | 607560 | 0 | 0 |
| ARCTURUS THERAPEUTICS HLDGS | COM | 03969T109 |  | 848000 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| ARK ETF TR | PUT | 00214Q952 |  | 25407000 | 900000 | SH | Put | SOLE |  | 900000 | 0 | 0 |
| ARK ETF TR | PUT | 00214Q954 |  | 38269000 | 1225000 | SH | Put | SOLE |  | 1225000 | 0 | 0 |
| ARROWHEAD PHARMACEUTICALS IN | CALL | 04280A900 |  | 803088 | 19800 | SH | Call | SOLE |  | 0 | 0 | 0 |
| ATHIRA PHARMA INC | COM | 04746L104 |  | 246309 | 77700 | SH |  | SOLE |  | 77700 | 0 | 0 |
| AVADEL PHARMACEUTICALS PLC | SPONSORED ADR | 05337M104 |  | 1861600 | 260000 | SH |  | SOLE |  | 260000 | 0 | 0 |
| AVANTOR INC | COM | 05352A100 |  | 731823 | 34700 | SH |  | SOLE |  | 34700 | 0 | 0 |
| AVITA MEDICAL INC | COM | 05380C102 |  | 6165938 | 934233 | SH |  | SOLE |  | 934233 | 0 | 0 |
| ANAVEX LIFE SCIENCES CORP | CALL | 032797900 |  | 2778000 | 300000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| AZENTA INC | COM | 114340102 |  | 7335720 | 126000 | SH |  | SOLE |  | 126000 | 0 | 0 |
| BAXTER INTL INC | CALL | 071813909 |  | 45873000 | 900000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| BICYCLE THERAPEUTICS PLC | SPONSORED ADS | 088786108 |  | 7074844 | 239015 | SH |  | SOLE |  | 239015 | 0 | 0 |
| BIOGEN INC | CALL | 09062X903 |  | 28633528 | 103400 | SH | Call | SOLE |  | 0 | 0 | 0 |
| BIOCRYST PHARMACEUTICALS INC | COM | 09058V103 |  | 1224101 | 106629 | SH |  | SOLE |  | 106629 | 0 | 0 |
| BIOGEN INC | COM | 09062X103 |  | 17368422 | 62720 | SH |  | SOLE |  | 62720 | 0 | 0 |
| BIONTECH SE | SPONSORED ADS | 09075V102 |  | 4235453 | 28195 | SH |  | SOLE |  | 28195 | 0 | 0 |
| BIO-TECHNE CORP | COM | 09073M104 |  | 5635840 | 68000 | SH |  | SOLE |  | 68000 | 0 | 0 |
| BIOVENTUS INC | COM CL A | 09075A108 |  | 65250 | 25000 | SH |  | SOLE |  | 25000 | 0 | 0 |
| CEREVEL THERAPEUTICS HLDNG I | COM | 15678U128 |  | 441560 | 14000 | SH |  | SOLE |  | 14000 | 0 | 0 |
| CANOPY GROWTH CORP | CALL | 138035900 |  | 4042500 | 1750000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| CHINOOK THERAPEUTICS INC | COM | 16961L106 |  | 2358000 | 90000 | SH |  | SOLE |  | 90000 | 0 | 0 |
| CELLDEX THERAPEUTICS INC NEW | CALL | 15117B902 |  | 8762462 | 196600 | SH | Call | SOLE |  | 0 | 0 | 0 |
| CONCERT PHARMACEUTICALS INC | CALL | 206022905 |  | 347480 | 59500 | SH | Call | SOLE |  | 0 | 0 | 0 |
| CONMED CORP | PUT | 207410951 |  | 4910656 | 55400 | SH | Put | SOLE |  | 55400 | 0 | 0 |
| CONCERT PHARMACEUTICALS INC | COM | 206022105 |  | 1206106 | 206525 | SH |  | SOLE |  | 206525 | 0 | 0 |
| COOPER COS INC | COM NEW | 216648402 |  | 5092318 | 15400 | SH |  | SOLE |  | 15400 | 0 | 0 |
| CUREVAC N V | COM | N2451R105 |  | 731939 | 121383 | SH |  | SOLE |  | 121383 | 0 | 0 |
| CUREVAC N V | COM | N2451R105 |  | 41724 | 6862 | SH |  | SOLE |  | 6862 | 0 | 0 |
| CUTERA INC | COM | 232109108 |  | 45812849 | 1036021 | SH |  | SOLE |  | 1036021 | 0 | 0 |
| CUTERA INC | CALL | 232109908 |  | 10723350 | 242500 | SH | Call | SOLE |  | 0 | 0 | 0 |
| CUREVAC N V | CALL | N2451R905 |  | 603000 | 100000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| CVS HEALTH CORP | PUT | 126650950 |  | 9319000 | 100000 | SH | Put | SOLE |  | 100000 | 0 | 0 |
| CYTEK BIOSCIENCES INC | COM | 23285D109 |  | 4295847 | 420749 | SH |  | SOLE |  | 420749 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 11229835 | 25000 | PRN |  | SOLE |  | 25000 | 0 | 0 |
| DEXCOM INC | COM | 252131107 |  | 8055780 | 71139 | SH |  | SOLE |  | 71139 | 0 | 0 |
| DANAHER CORPORATION | PUT | 235851952 |  | 17252300 | 65000 | SH | Put | SOLE |  | 65000 | 0 | 0 |
| ELEVANCE HEALTH INC | PUT | 036752953 |  | 10259400 | 20000 | SH | Put | SOLE |  | 20000 | 0 | 0 |
| ESPERION THERAPEUTICS INC NE | COM | 29664W105 |  | 1920790 | 308313 | SH |  | SOLE |  | 308313 | 0 | 0 |
| ESTABLISHMENT LABS HLDGS INC | CALL | G31249908 |  | 1641250 | 25000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| ESTABLISHMENT LABS HLDGS INC | COM | G31249108 |  | 62549154 | 952767 | SH |  | SOLE |  | 952767 | 0 | 0 |
| 89BIO INC | CALL | 282559903 |  | 649230 | 51000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| EVAXION BIOTECH A S | ADS | 29970R105 |  | 29895 | 16842 | SH |  | SOLE |  | 16842 | 0 | 0 |
| EVOLENT HEALTH INC | CL A | 30050B101 |  | 3262896 | 116200 | SH |  | SOLE |  | 116200 | 0 | 0 |
| EVOLUS INC | COM | 30052C107 |  | 375500 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| EXACT SCIENCES CORP | CALL | 30063P905 |  | 13615250 | 275000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| EXELIXIS INC | COM | 30161Q104 |  | 1203000 | 75000 | SH |  | SOLE |  | 75000 | 0 | 0 |
| FIRST TR EXCHANGE TRADED FD | PUT | 33734X953 |  | 76111000 | 700000 | SH | Put | SOLE |  | 700000 | 0 | 0 |
| GERON CORP | CALL | 374163903 |  | 4391332 | 1814600 | SH | Call | SOLE |  | 0 | 0 | 0 |
| GERON CORP | PUT | 374163953 |  | 1508386 | 623300 | SH | Put | SOLE |  | 623300 | 0 | 0 |
| GUARDANT HEALTH INC | CALL | 40131M909 |  | 11122080 | 408900 | SH | Call | SOLE |  | 0 | 0 | 0 |
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 |  | 1538938 | 158327 | SH |  | SOLE |  | 158327 | 0 | 0 |
| GLAUKOS CORP | CALL | 377322902 |  | 10920000 | 250000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| GLAUKOS CORP | COM | 377322102 |  | 33242620 | 761049 | SH |  | SOLE |  | 761049 | 0 | 0 |
| GLYCOMIMETICS INC | CALL | 38000Q902 |  | 535098 | 176600 | SH | Call | SOLE |  | 0 | 0 | 0 |
| GLYCOMIMETICS INC | COM | 38000Q102 |  | 95793 | 31615 | SH |  | SOLE |  | 31615 | 0 | 0 |
| GOSSAMER BIO INC | NOTE 5.000% 6/0 | 38341PAA0 |  | 161750 | 5000 | PRN |  | SOLE |  | 5000 | 0 | 0 |
| GUARDANT HEALTH INC | COM | 40131M109 |  | 11610973 | 426874 | SH |  | SOLE |  | 426874 | 0 | 0 |
| HOLOGIC INC | PUT | 436440951 |  | 7884974 | 105400 | SH | Put | SOLE |  | 105400 | 0 | 0 |
| HORIZON THERAPEUTICS PUB L | SHS | G46188101 |  | 1468020 | 12900 | SH |  | SOLE |  | 12900 | 0 | 0 |
| HENRY SCHEIN INC | PUT | 806407952 |  | 11181800 | 140000 | SH | Put | SOLE |  | 140000 | 0 | 0 |
| HUMANA INC | PUT | 444859952 |  | 10243800 | 20000 | SH | Put | SOLE |  | 20000 | 0 | 0 |
| INTEGRA LIFESCIENCES HLDGS C | PUT | 457985958 |  | 11298105 | 201500 | SH | Put | SOLE |  | 201500 | 0 | 0 |
| ICAD INC | COM NEW | 44934S206 |  | 2028864 | 1108669 | SH |  | SOLE |  | 1108669 | 0 | 0 |
| ICU MED INC | COM | 44930G107 |  | 6273216 | 39835 | SH |  | SOLE |  | 39835 | 0 | 0 |
| ICU MED INC | CALL | 44930G907 |  | 18897600 | 120000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| IDEXX LABS INC | PUT | 45168D954 |  | 8159200 | 20000 | SH | Put | SOLE |  | 20000 | 0 | 0 |
| ISHARES TR | PUT | 464288950 |  | 78855000 | 1500000 | SH | Put | SOLE |  | 1500000 | 0 | 0 |
| ILLUMINA INC | CALL | 452327909 |  | 11626500 | 57500 | SH | Call | SOLE |  | 0 | 0 | 0 |
| IMMUNOGEN INC | COM | 45253H101 |  | 248000 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| INCYTE CORP | COM | 45337C102 |  | 2441728 | 30400 | SH |  | SOLE |  | 30400 | 0 | 0 |
| INHIBRX INC | COM | 45720L107 |  | 2305688 | 93575 | SH |  | SOLE |  | 93575 | 0 | 0 |
| INMODE LTD | PUT | M5425M953 |  | 7140000 | 200000 | SH | Put | SOLE |  | 200000 | 0 | 0 |
| INSPIRE MED SYS INC | COM | 457730109 |  | 50623850 | 200984 | SH |  | SOLE |  | 200984 | 0 | 0 |
| INTUITIVE SURGICAL INC | COM NEW | 46120E602 |  | 2653500 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| IRHYTHM TECHNOLOGIES INC | CALL | 450056906 |  | 6556900 | 70000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| IVERIC BIO INC | CALL | 46583P902 |  | 4915736 | 229600 | SH | Call | SOLE |  | 0 | 0 | 0 |
| IVERIC BIO INC | PUT | 46583P952 |  | 421777 | 19700 | SH | Put | SOLE |  | 19700 | 0 | 0 |
| INTUITIVE SURGICAL INC | CALL | 46120E902 |  | 29188500 | 110000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| IVERIC BIO INC | COM | 46583P102 |  | 25327495 | 1182975 | SH |  | SOLE |  | 1182975 | 0 | 0 |
| ISHARES TR | PUT | 464287955 |  | 95898000 | 550000 | SH | Put | SOLE |  | 550000 | 0 | 0 |
| KALVISTA PHARMACEUTICALS INC | COM | 483497103 |  | 4953066 | 732702 | SH |  | SOLE |  | 732702 | 0 | 0 |
| LANTHEUS HLDGS INC | COM | 516544103 |  | 5945248 | 116665 | SH |  | SOLE |  | 116665 | 0 | 0 |
| LIQUIDIA CORPORATION | COM NEW | 53635D202 |  | 1328368 | 208535 | SH |  | SOLE |  | 208535 | 0 | 0 |
| LIVANOVA PLC | SHS | G5509L101 |  | 12660399 | 227951 | SH |  | SOLE |  | 227951 | 0 | 0 |
| LIVANOVA PLC | CALL | G5509L901 |  | 16717540 | 301000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| PULMONX CORP | CALL | 745848901 |  | 843000 | 100000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| MERRIMACK PHARMACEUTICALS IN | CALL | 590328909 |  | 460692 | 40200 | SH | Call | SOLE |  | 0 | 0 | 0 |
| MADRIGAL PHARMACEUTICALS INC | PUT | 558868955 |  | 10449000 | 36000 | SH | Put | SOLE |  | 36000 | 0 | 0 |
| MEDTRONIC PLC | PUT | G5960L953 |  | 10103600 | 130000 | SH | Put | SOLE |  | 130000 | 0 | 0 |
| MERRIMACK PHARMACEUTICALS IN | COM NEW | 590328209 |  | 734586 | 64100 | SH |  | SOLE |  | 64100 | 0 | 0 |
| MILESTONE PHARMACEUTICALS IN | COM | 59935V107 |  | 1472280 | 371788 | SH |  | SOLE |  | 371788 | 0 | 0 |
| MIRATI THERAPEUTICS INC | CALL | 60468T905 |  | 5536882 | 122200 | SH | Call | SOLE |  | 0 | 0 | 0 |
| MIRATI THERAPEUTICS INC | PUT | 60468T955 |  | 566375 | 12500 | SH | Put | SOLE |  | 12500 | 0 | 0 |
| ADVISORSHARES TR | CALL | 00768Y903 |  | 15727500 | 2250000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| NANOSTRING TECHNOLOGIES INC | COM | 63009R109 |  | 7249512 | 909600 | SH |  | SOLE |  | 909600 | 0 | 0 |
| INARI MED INC | PUT | 45332Y959 |  | 1906800 | 30000 | SH | Put | SOLE |  | 30000 | 0 | 0 |
| NATERA INC | COM | 632307104 |  | 6628050 | 165000 | SH |  | SOLE |  | 165000 | 0 | 0 |
| NGM BIOPHARMACEUTICALS INC | CALL | 62921N905 |  | 302706 | 60300 | SH | Call | SOLE |  | 0 | 0 | 0 |
| NGM BIOPHARMACEUTICALS INC | COM | 62921N105 |  | 417433 | 83154 | SH |  | SOLE |  | 83154 | 0 | 0 |
| NOVOCURE LTD | ORD SHS | G6674U108 |  | 3667500 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| NANOSTRING TECHNOLOGIES INC | CALL | 63009R909 |  | 10251811 | 1286300 | SH | Call | SOLE |  | 0 | 0 | 0 |
| NUVALENT INC | COM | 670703107 |  | 2100175 | 70523 | SH |  | SOLE |  | 70523 | 0 | 0 |
| NOVOCURE LTD | CALL | G6674U908 |  | 2567250 | 35000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| NOVOCURE LTD | PUT | G6674U958 |  | 19445085 | 265100 | SH | Put | SOLE |  | 265100 | 0 | 0 |
| INVITAE CORP | CALL | 46185L903 |  | 744000 | 400000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| NYXOAH S A | SHS | B6S7WD106 |  | 801378 | 149131 | SH |  | SOLE |  | 149131 | 0 | 0 |
| OLINK HLDG AB | SPONSORED ADS | 680710100 |  | 12439423 | 490127 | SH |  | SOLE |  | 490127 | 0 | 0 |
| OUTSET MED INC | CALL | 690145907 |  | 9703156 | 375800 | SH | Call | SOLE |  | 0 | 0 | 0 |
| ONCOCYTE CORP | COM | 68235C107 |  | 5794258 | 18056274 | SH |  | SOLE |  | 18056274 | 0 | 0 |
| ORAMED PHARMACEUTICALS INC | CALL | 68403P903 |  | 2231565 | 185500 | SH | Call | SOLE |  | 0 | 0 | 0 |
| OUTSET MED INC | COM | 690145107 |  | 11732350 | 454390 | SH |  | SOLE |  | 454390 | 0 | 0 |
| PACIFIC BIOSCIENCES CALIF IN | COM | 69404D108 |  | 818000 | 100000 | SH |  | SOLE |  | 100000 | 0 | 0 |
| PENUMBRA INC | CALL | 70975L907 |  | 9321074 | 41900 | SH | Call | SOLE |  | 0 | 0 | 0 |
| PFIZER INC | CALL | 717081903 |  | 5124000 | 100000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| KONINKLIJKE PHILIPS N V | PUT | 500472953 |  | 4497000 | 300000 | SH | Put | SOLE |  | 300000 | 0 | 0 |
| VANECK ETF TRUST | PUT | 92189F952 |  | 31096000 | 400000 | SH | Put | SOLE |  | 400000 | 0 | 0 |
| PROMETHEUS BIOSCIENCES INC | COM | 74349U108 |  | 2310000 | 21000 | SH |  | SOLE |  | 21000 | 0 | 0 |
| PROTHENA CORP PLC | SHS | G72800108 |  | 3856000 | 64000 | SH |  | SOLE |  | 64000 | 0 | 0 |
| PRIVIA HEALTH GROUP INC | CALL | 74276R902 |  | 7948500 | 350000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| PULMONX CORP | COM | 745848101 |  | 8567055 | 1016258 | SH |  | SOLE |  | 1016258 | 0 | 0 |
| QIAGEN NV | SHS NEW | N72482123 |  | 548570 | 11000 | SH |  | SOLE |  | 11000 | 0 | 0 |
| INVESCO QQQ TR | PUT | 46090E953 |  | 107843400 | 405000 | SH | Put | SOLE |  | 405000 | 0 | 0 |
| QUANTERIX CORP | CALL | 74766Q901 |  | 15315330 | 1105800 | SH | Call | SOLE |  | 0 | 0 | 0 |
| QUANTERIX CORP | COM | 74766Q101 |  | 7287053 | 526141 | SH |  | SOLE |  | 526141 | 0 | 0 |
| R1 RCM INC | COM | 77634L105 |  | 4927500 | 450000 | SH |  | SOLE |  | 450000 | 0 | 0 |
| ROCKET PHARMACEUTICALS INC | PUT | 77313F956 |  | 2935500 | 150000 | SH | Put | SOLE |  | 150000 | 0 | 0 |
| RELMADA THERAPEUTICS INC | COM | 75955J402 |  | 77593 | 22233 | SH |  | SOLE |  | 22233 | 0 | 0 |
| REPLIGEN CORP | PUT | 759916959 |  | 3352338 | 19800 | SH | Put | SOLE |  | 19800 | 0 | 0 |
| RELMADA THERAPEUTICS INC | CALL | 75955J902 |  | 69800 | 20000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| ROIVANT SCIENCES LTD | *W EXP 09/30/202 | G76279119 |  | 387317 | 199648 | SH |  | SOLE |  | 199648 | 0 | 0 |
| PROMETHEUS BIOSCIENCES INC | PUT | 74349U958 |  | 1375000 | 12500 | SH | Put | SOLE |  | 12500 | 0 | 0 |
| SAREPTA THERAPEUTICS INC | DEBT 1.250% 9/1 | 803607AC4 |  | 2893750 | 25000 | PRN |  | SOLE |  | 25000 | 0 | 0 |
| SAVARA INC | COM | 805111101 |  | 147272 | 95014 | SH |  | SOLE |  | 95014 | 0 | 0 |
| SCHRODINGER INC | COM | 80810D103 |  | 4859400 | 260000 | SH |  | SOLE |  | 260000 | 0 | 0 |
| SEER INC | PUT | 81578P956 |  | 1450000 | 250000 | SH | Put | SOLE |  | 250000 | 0 | 0 |
| THE BEAUTY HEALTH COMPANY | PUT | 88331L958 |  | 1820000 | 200000 | SH | Put | SOLE |  | 200000 | 0 | 0 |
| SUMMIT THERAPEUTICS INC | CALL | 86627T908 |  | 850000 | 200000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| SOMALOGIC INC | *W EXP 08/31/202 | 83444K113 |  | 81760 | 204401 | SH |  | SOLE |  | 204401 | 0 | 0 |
| SONENDO INC | COM | 835431107 |  | 13912407 | 4916045 | SH |  | SOLE |  | 4916045 | 0 | 0 |
| SOPHIA GENETICS SA | ORDINARY SHARES | H82027105 |  | 1553314 | 754036 | SH |  | SOLE |  | 754036 | 0 | 0 |
| SPRINGBIG HOLDINGS INC | *W EXP 06/14/202 | 85021Q116 |  | 211 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| SPDR S 500 ETF TR | PUT | 78462F953 |  | 110904700 | 290000 | SH | Put | SOLE |  | 290000 | 0 | 0 |
| SAREPTA THERAPEUTICS INC | CALL | 803607900 |  | 25916000 | 200000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| STAAR SURGICAL CO | PUT | 852312955 |  | 20629500 | 425000 | SH | Put | SOLE |  | 425000 | 0 | 0 |
| STAAR SURGICAL CO | COM PAR $0.01 | 852312305 |  | 8412467 | 173310 | SH |  | SOLE |  | 173310 | 0 | 0 |
| STERIS PLC | SHS USD | G8473T100 |  | 2862695 | 15500 | SH |  | SOLE |  | 15500 | 0 | 0 |
| STEVANATO GROUP S P A | ORD SHS | T9224W109 |  | 754740 | 42000 | SH |  | SOLE |  | 42000 | 0 | 0 |
| SUTRO BIOPHARMA INC | COM | 869367102 |  | 253785 | 31409 | SH |  | SOLE |  | 31409 | 0 | 0 |
| STRYKER CORPORATION | PUT | 863667951 |  | 22004100 | 90000 | SH | Put | SOLE |  | 90000 | 0 | 0 |
| SYNEOS HEALTH INC | CALL | 87166B902 |  | 5502000 | 150000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| TALKSPACE INC | *W EXP 06/21/202 | 87427V111 |  | 31142 | 427194 | SH |  | SOLE |  | 427194 | 0 | 0 |
| TRICIDA INC | CALL | 89610F901 |  | 45870 | 300000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| TELA BIO INC | COM | 872381108 |  | 5980909 | 520079 | SH |  | SOLE |  | 520079 | 0 | 0 |
| TERNS PHARMACEUTICALS INC | COM | 880881107 |  | 6159704 | 605079 | SH |  | SOLE |  | 605079 | 0 | 0 |
| TG THERAPEUTICS INC | COM | 88322Q108 |  | 5972127 | 504829 | SH |  | SOLE |  | 504829 | 0 | 0 |
| TG THERAPEUTICS INC | CALL | 88322Q908 |  | 2957500 | 250000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| TG THERAPEUTICS INC | PUT | 88322Q958 |  | 7016373 | 593100 | SH | Put | SOLE |  | 593100 | 0 | 0 |
| TRANSMEDICS GROUP INC | PUT | 89377M959 |  | 5554800 | 90000 | SH | Put | SOLE |  | 90000 | 0 | 0 |
| THERMO FISHER SCIENTIFIC INC | PUT | 883556952 |  | 22027600 | 40000 | SH | Put | SOLE |  | 40000 | 0 | 0 |
| TRANSMEDICS GROUP INC | COM | 89377M109 |  | 5554800 | 90000 | SH |  | SOLE |  | 90000 | 0 | 0 |
| TRAVERE THERAPEUTICS INC | NOTE 2.250% 3/0 | 89422GAA5 |  | 457500 | 5000 | PRN |  | SOLE |  | 5000 | 0 | 0 |
| TRUPANION INC | PUT | 898202956 |  | 3564750 | 75000 | SH | Put | SOLE |  | 75000 | 0 | 0 |
| TWIST BIOSCIENCE CORP | PUT | 90184D950 |  | 2381000 | 100000 | SH | Put | SOLE |  | 100000 | 0 | 0 |
| UNITEDHEALTH GROUP INC | PUT | 91324P952 |  | 31810800 | 60000 | SH | Put | SOLE |  | 60000 | 0 | 0 |
| UNITED THERAPEUTICS CORP DEL | COM | 91307C102 |  | 10103844 | 36333 | SH |  | SOLE |  | 36333 | 0 | 0 |
| VAXCYTE INC | COM | 92243G108 |  | 2950268 | 61528 | SH |  | SOLE |  | 61528 | 0 | 0 |
| VERA THERAPEUTICS INC | CL A | 92337R101 |  | 684448 | 35372 | SH |  | SOLE |  | 35372 | 0 | 0 |
| VERASTEM INC | COM | 92337C104 |  | 404219 | 1004272 | SH |  | SOLE |  | 1004272 | 0 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 |  | 808584 | 2800 | SH |  | SOLE |  | 2800 | 0 | 0 |
| VIEWRAY INC | COM | 92672L107 |  | 56219560 | 12549009 | SH |  | SOLE |  | 12549009 | 0 | 0 |
| VIRIDIAN THERAPEUTICS INC | COM | 92790C104 |  | 1022438 | 35003 | SH |  | SOLE |  | 35003 | 0 | 0 |
| VIEWRAY INC | CALL | 92672L907 |  | 16576000 | 3700000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| WM TECHNOLOGY INC | *W EXP 06/16/202 | 92971A117 |  | 5000 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| SPDR SER TR | CALL | 78464A900 |  | 8233600 | 99200 | SH | Call | SOLE |  | 0 | 0 | 0 |
| SPDR SER TR | PUT | 78464A950 |  | 47310000 | 570000 | SH | Put | SOLE |  | 570000 | 0 | 0 |
| LYRA THERAPEUTICS INC | COM | 55234L105 |  | 6773916 | 2157298 | SH |  | SOLE |  | 2157298 | 0 | 0 |
| MEDAVAIL HOLDINGS INC | COM | 58406B103 |  | 99462 | 331761 | SH |  | SOLE |  | 331761 | 0 | 0 |
| SELECT SECTOR SPDR TR | PUT | 81369Y959 |  | 29887000 | 220000 | SH | Put | SOLE |  | 220000 | 0 | 0 |

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