# EDGAR Filing Document

**Accession Number:** 0001124140
**File Stem:** 0001124140-25-000072
**Filing Date:** 2025-7
**Character Count:** 39345
**Document Hash:** 526245b40846076653abc6bc0e70c95f
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001124140-25-000072.hdr.sgml**: 20250711

**ACCESSION NUMBER**: 0001124140-25-000072

**CONFORMED SUBMISSION TYPE**: S-8 POS

**PUBLIC DOCUMENT COUNT**: 4

**FILED AS OF DATE**: 20250711

**DATE AS OF CHANGE**: 20250711

**EFFECTIVENESS DATE**: 20250711

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** EXACT SCIENCES CORP
- **CENTRAL INDEX KEY:** 0001124140
- **STANDARD INDUSTRIAL CLASSIFICATION:** SERVICES-MEDICAL LABORATORIES [8071]
- **ORGANIZATION NAME:** 08 Industrial Applications and Services
- **EIN:** 204782291
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8 POS
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-273572
- **FILM NUMBER:** 251119071

**BUSINESS ADDRESS:**
- **STREET 1:** 5505 ENDEAVOR LANE
- **CITY:** MADISON
- **STATE:** WI
- **ZIP:** 53719
- **BUSINESS PHONE:** 608-284-5700

**MAIL ADDRESS:**
- **STREET 1:** 5505 ENDEAVOR LANE
- **CITY:** MADISON
- **STATE:** WI
- **ZIP:** 53719

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** EXACT CORP
- **DATE OF NAME CHANGE:** 20000919

**As filed with the Securities and Exchange Commission on July 11, 2025**

**Registration No. 333-273572** 

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**_____________________________________________________________________________**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-273572**

**REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933**

**_____________________________________________________________________________**

**EXACT SCIENCES CORPORATION**

(Exact name of registrant as specified in its charter)

**_____________________________________________________________________________**

---

| | |
|:---|:---|
| **Delaware**<br>(State or other jurisdiction of incorporation or organization) | **02-0478229**<br>(I.R.S. Employer Identification No.) |
| **5505 Endeavor Lane, Madison, Wisconsin**<br>(Address of principal executive offices) | **53719**<br>(Zip Code) |

---

**Exact Sciences Corporation 2010 Omnibus Long-Term Incentive Plan (as amended and restated effective July 27, 2017)**

**Exact Sciences Corporation 2019 Omnibus Long-Term Incentive Plan**

**Exact Sciences Corporation 2025 Omnibus Long-Term Incentive Plan**

(Full title of the plan)

**James Herriott**

**Senior Vice President, General Counsel and Secretary**

**Exact Sciences Corporation**

**5505 Endeavor Lane** 

**Madison, WI 53719**

(Name and address of agent for service)

**(608) 284-5700**

(Telephone number, including area code, of agent for service)

**_____________________________________________________________________________**

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | **☒** | Accelerated filer | **☐** |
| Non-accelerated filer | **☐** | Smaller reporting company | **☐** |
| | | Emerging growth company | **☐** |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards pursuant to Section 7(a)(2)(B) of the Securities Act. **☐**

**_____________________________________________________________________________**

------

**EXPLANATORY NOTE**

Exact Sciences Corporation, a Delaware corporation (the "Company" or "Registrant") has previously registered shares of the Registrant's common stock, par value $0.01 per share (the "Common Stock") to be issued under the Exact Sciences Corporation 2010 Omnibus Long-Term Incentive Plan (As Amended and Restated Effective July 27, 2017) (the "2010 Plan") and the Exact Sciences Corporation 2019 Omnibus Long-Term Incentive Plan (as last amended on June 8, 2023, the "2019 Plan", and together with the 2010 Plan, the "Prior Plans"). In connection with the Prior Plans, the Registrant has previously filed with the Securities and Exchange Commission (the "SEC") (i) a Registration Statement on Form S-8 on August 17, 2010 (File No. 333-168909), (ii) a Registration Statement on Form S-8 on August 2, 2013 (File No. 333-190350), (iii) a Registration Statement on Form S-8 on October 30, 2015 (File No. 333-207703), (iv) a Registration Statement on Form S-8 on July 28, 2017 (File No. 333-219553), (v) Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-219553 on July 31, 2019, (vi) a Registration Statement on Form S-8 (File No. 333-232916) on July 31, 2019, (vii) a Registration Statement on Form S-8 (File No. 333-234608) on November 8, 2019, (viii) a Registration Statement on Form S-8 (File No. 333-266471) on August 2, 2022, and (ix) a Registration Statement on Form S-8 (File No. 333-273572) on August 1, 2023 (collectively, the "Prior Registration Statements").

On June 12, 2025 (the "Approval Date"), the stockholders of the Registrant approved the Exact Sciences Corporation 2025 Omnibus Long-Term Incentive Plan (the "2025 Plan"). Pursuant to the terms of the 2025 Plan, the maximum number of shares of Common Stock that may be issued under the 2025 Plan shall be the sum of (i) 11,896,525 newly available shares of Common Stock less the number of shares of Common Stock the Registrant granted under the 2019 Plan between March 31, 2025 and June 12, 2025 (the "New Shares") plus (ii) any shares of Common Stock subject to stock options or other awards granted under the Prior Plans as of the Approval Date that expire or are terminated, surrendered or forfeited for any reason without the issuance of shares of Common Stock (the "Rollover Shares"). No further awards will be granted under the Prior Plans on or after the Approval Date.

The Registrant is filing this Post-Effective Amendment No. 1 to the Registration Statement on Form S-8 (this "Post-Effective Amendment") pursuant to Securities Act Forms Compliance and Disclosure Interpretation Question 126.43, reflecting the interpretative position of the Division of Corporation Finance of the SEC to amend the Registration Statement to also cover the registration of the Rollover Shares under the 2025 Plan (to the extent such shares are, or become no longer issuable under the Prior Plans and instead are, or become, issuable under the 2025 Plan).

Contemporaneously with the filing of this Post-Effective Amendment, the Registrant is filing a registration statement on Form S-8 to register the New Shares that have become available for offer or sale pursuant to the 2025 Plan. No additional securities are being registered by this Post-Effective Amendment.

**PART I**

**INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS**

**Item 1. Plan Information.**

The information required by this Item 1 is omitted from this filing and is included in documents sent or provided to participants of the 2025 Plan in accordance with Rule 428(b)(1) of the Securities Act and the Note to Part I of Form S-8. These documents and the documents incorporated by reference in the applicable Registration Statement pursuant to Item 3 of Part II of this form, taken together, constitute prospectuses that meet the requirements of Section 10(a) of the Securities Act.

**Item 2. Registrant Information and Employee Plan Annual Information.** 

The information required by this Item 2 is omitted from this filing and is included in documents sent or provided to participants of the 2025 Plan in accordance with Rule 428(b)(1) of the Securities Act and the Note to Part I of Form S-8. These documents and the documents incorporated by reference in the applicable Registration Statement pursuant to Item 3 of Part II of this form, taken together, constitute prospectuses that meet the requirements of Section 10(a) of the Securities Act.

------

**PART II**

**INFORMATION REQUIRED IN THE REGISTRATION STATEMENT**

**Item 3. Incorporation of Documents by Reference.**

The following documents have been filed by Exact Sciences Corporation, a Delaware corporation (the "Company" or "Registrant") with the U.S. Securities and Exchange Commission (the "Commission") and are incorporated herein by reference:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Annual Report on Form 10-K for the fiscal year ended December 31, 2024, filed with the Commission on <u>[February 19, 2025](https://www.sec.gov/ix?doc=/Archives/edgar/data/0001124140/000112414025000020/exas-20241231.htm)</u>;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Quarterly Report on Form 10-Q for the quarter ended March 31, 2025, filed with the Commission on <u>[May 1, 2025](https://www.sec.gov/ix?doc=/Archives/edgar/data/0001124140/000112414025000043/exas-20250331.htm)</u>;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Current Reports on Form 8-K, filed with the Commission on <u>[January 6, 2025](https://www.sec.gov/ix?doc=/Archives/edgar/data/0001124140/000112414025000003/exas-20250102.htm)</u>, <u>[January 13, 2025](https://www.sec.gov/ix?doc=/Archives/edgar/data/0001124140/000112414025000008/exas-20250112.htm)</u>, <u>[April 29, 2025](https://www.sec.gov/ix?doc=/Archives/edgar/data/0001124140/000112414025000032/exas-20250429.htm)</u>, and <u>[June 16, 2025](https://www.sec.gov/ix?doc=/Archives/edgar/data/0001124140/000112414025000046/exas-20250612.htm)</u>;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• the portions of the Registrant's Definitive Proxy Statement on Schedule 14A filed on <u>[April 29, 2025](https://www.sec.gov/ix?doc=/Archives/edgar/data/0001124140/000112414025000034/exas-20250429.htm)</u> that are specifically incorporated by reference into the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2024; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• The description of the Registrant's Common Stock contained in the Registrant's registration statement on Form 8-A, filed with the SEC pursuant to Section 12(g) of the Exchange Act on <u>[December 26, 2000](https://www.sec.gov/Archives/edgar/data/1124140/000091205700054713/a2033604z8-a12g.txt)</u>, as updated by Exhibit 4.6 to our Annual Report on Form 10-K for the fiscal year ended December 31, 2020, filed on February 16, 2021, including any amendments or reports filed for the purpose of updating such description.

All reports and other documents filed by the Registrant pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act after the date hereof, and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be part hereof from the date of filing of such reports and documents. The Registrant is not incorporating by reference any reports or documents or portions thereof that are not considered to be "filed" with the Commission.

Any statement contained herein or in a document incorporated or deemed to be incorporated herein by reference shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated herein by reference modifies or supersedes such earlier statement. Any statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.

**Item 4. Description of Securities.**

Not applicable.

**Item 5. Interests of Named Experts and Counsel.**

Not applicable.

**Item 6. Indemnification of Directors and Officers.**

Section 102(b)(7) of the General Corporation Law of the State of Delaware (the "<u>DGCL</u>"), allows a corporation to provide in its certificate of incorporation that a director or officer of the corporation will not be personally liable to the corporation or its stockholders for monetary damages for breach of fiduciary duty as a director or officer, except where the director or officer breached his or her duty of loyalty to the corporation or its stockholders, the director or officer failed to act in good faith or engaged in intentional misconduct or knowingly violated a law, the

------

director authorized the payment of a dividend or approved a stock repurchase in violation of the DGCL, or the director or officer obtained an improper personal benefit, or, solely in the case of an officer, in any action by or in the right of the corporation. The Company's amended and restated certificate of incorporation (the "<u>Certificate of Incorporation</u>") provides for this limitation of liability solely for its directors.

Section 145 of the DGCL ("<u>Section 145</u>") provides that a Delaware corporation may indemnify any person who was or is a party, or is threatened to be made a party, to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action by or in the right of such corporation), by reason of the fact that such person is or was an officer, director, employee or agent of such corporation or is or was serving at the request of such corporation as a director, officer, employee or agent of another corporation or enterprise. The indemnity may include expenses (including attorneys' fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by such person in connection with such action, suit or proceeding, provided such person acted in good faith and in a manner he or she reasonably believed to be in or not opposed to the corporation's best interests and, with respect to any criminal action or proceeding, had no reasonable cause to believe that his or her conduct was illegal. A Delaware corporation may indemnify any persons who were or are a party to any threatened, pending or completed action or suit by or in the right of the corporation by reason of the fact that such person is or was a director, officer, employee or agent of another corporation or enterprise. The indemnity may include expenses (including attorneys' fees) actually and reasonably incurred by such person in connection with the defense or settlement of such action or suit, provided such person acted in good faith and in a manner he or she reasonably believed to be in or not opposed to the corporation's best interests, provided that no indemnification is permitted without judicial approval if the officer, director, employee or agent is adjudged to be liable to the corporation. Where an officer or director is successful on the merits or otherwise in the defense of any action referred to above, the corporation must indemnify him or her against the expenses which such officer or director has actually and reasonably incurred.

Section 145 further authorizes a corporation to purchase and maintain insurance on behalf of any person who is or was a director, officer, employee or agent of the corporation or is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation or enterprise, against any liability asserted against him or her and incurred by him or her in any such capacity, or arising out of his or her status as such, whether or not the corporation would otherwise have the power to indemnify him or her under Section 145.

In addition, the Certificate of Incorporation provides that the Company shall indemnify each person who was or is a party, or is threatened to be made a party to, any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative, by reason of the fact that such person is or was, or has agreed to become, one of the Company's directors or officers or is or was serving, or has agreed to serve, at the Company's request as a director, officer or trustee of another corporation, partnership, joint venture, trust, employee benefit plan or other enterprise, against all expenses, including attorneys' fees, judgments, fines and amounts paid in settlement actually and reasonably incurred by such person in connection with such action, suit or proceeding and any appeal therefrom, if he acted in good faith and in a manner he or she reasonably believed to be in, or not opposed to, the best interests of the Company, and with respect to any criminal action or proceeding, had no reasonable cause to believe his conduct was unlawful.

All of the Company's directors and officers are covered by insurance policies maintained by the Company against specified liabilities for actions taken in their capacities as such, including liabilities under the Securities Act. Additionally, insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Company pursuant to the foregoing provisions, or otherwise, the Company has been advised that, in the opinion of the SEC, such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.

**Item 7. Exemption from Registration Claimed.**

Not applicable.

------

**Item 8. Exhibits**

---

| | |
|:---|:---|
| **Exhibit<br>Number** | **Exhibit Title** |
| <u>[4.1](https://www.sec.gov/Archives/edgar/data/1124140/000091205700052154/a2031350zex-3_3.txt)</u> | Sixth Amended and Restated Certificate of Incorporation of the Registrant (previously filed as Exhibit 3.3 to the Registrant's Form S-1 (File No. 333-48812) filed on December 4, 2000, which is incorporated herein by reference) |
| <u>[4.2](https://www.sec.gov/Archives/edgar/data/1124140/000112414020000044/exhibit31.htm)</u> | Certificate of Amendment to Sixth Amended and Restated Certificate of Incorporation of the Registrant (previously filed as Exhibit 3.1 to the Registrant's Current Report on Form 8-K filed on July 24, 2020, which is incorporated herein by reference) |
| <u>[4.3](https://www.sec.gov/Archives/edgar/data/1124140/000112414023000054/exas-20230612xexx31.htm)</u> | Certificate of Amendment to Sixth Amended and Restated Certificate of Incorporation of Exact Sciences Corporation (previously filed as Exhibit 3.1 to the Registrant's Current Report on Form 8-K filed on June 12, 2023, which is incorporated herein by reference)  |
| <u>[4.4](https://www.sec.gov/Archives/edgar/data/1124140/000112414023000054/exas-20230612xexx32.htm)</u> | Seventh Amended and Restated By-Laws of the Registrant, dated June 9, 2023 (previously filed as Exhibit 3.2 to the Registrant's Current Report on Form 8-K filed on June 12, 2023, which is incorporated herein by reference) |
| <u>[4.5](https://www.sec.gov/Archives/edgar/data/1124140/000112414025000046/exas-20250616xexx101.htm)</u> | Exact Sciences Corporation 2025 Omnibus Long-Term Incentive Plan, (previously filed as Exhibit 10.1 to the Registrant's Current Report on Form 8-K filed on June 16, 2025, which is incorporated herein by reference) |
| <u>[4.6](https://www.sec.gov/Archives/edgar/data/1124140/000155837017007717/exas-20170930ex1017426b8.htm)</u> | Exact Sciences Corporation 2010 Omnibus Long-Term Incentive Plan (As Amended and Restated Effective July 27, 2017) (previously filed as Exhibit 10.1 to the Registrant's Quarterly Report on Form 10-Q for the period ended September 30, 2017, which is incorporated herein by reference) |
| <u>[4.7](https://www.sec.gov/Archives/edgar/data/1124140/000110465919042922/a19-16293_1ex4d4.htm#Exhibit4_4_110716)</u> | Exact Sciences Corporation 2019 Omnibus Long-Term Incentive Plan (previously filed as Exhibit 4.4 to the Registrant's Registration Statement on Form S-8 filed on July 31, 2019, which is incorporated herein by reference) |
| <u>[4.8](https://www.sec.gov/Archives/edgar/data/1124140/000112414022000042/exas-20220610xexx101.htm)</u> | Amendment No. 1 to Exact Sciences Corporation 2019 Omnibus Long-Term Incentive Plan (previously filed as Exhibit 10.1 to the Registrant's Current Report on Form 8-K filed on June 9, 2022, which is incorporated herein by reference) |
| <u>[4.9](https://www.sec.gov/Archives/edgar/data/1124140/000112414023000054/exas-20230612xexx101.htm)</u> | Amendment No. 2 to Exact Sciences Corporation 2019 Omnibus Long-Term Incentive Plan (previously filed as Exhibit 10.1 to the Registrant's Current Report on Form 8-K filed on June 12, 2023, which is incorporated herein by reference) |
| <u>[5.1](exas-20250711xex51xsx8pos.htm)</u> | Opinion of K&L Gates LLP, filed herewith |
| <u>[23.1](exas-20250711xex231xsx8pos.htm)</u> | Consent of PricewaterhouseCoopers LLP, filed herewith |
| <u>[23.2](exas-20250711xex51xsx8pos.htm)</u> | Consent of K&L Gates LLP (contained in Exhibit 5.1 hereto and filed herewith) |

---

**Item 9. Undertakings**

A. The undersigned Registrant hereby undertakes:

&nbsp;&nbsp;&nbsp;&nbsp;(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) To include any prospectus required by Section 10(a)(3) of the Securities Act;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) To reflect in the prospectus any facts or events arising after the effective date of this Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this Registration Statement; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) To include any material information with respect to the plan of distribution not previously disclosed in this Registration Statement or any material change to such information in this Registration Statement;

------

*provided, however*, that paragraphs (A)(1)(i) and (A)(1)(ii) above do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in periodic reports filed by the Registrant pursuant to Section 13 or 15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.

&nbsp;&nbsp;&nbsp;&nbsp;(2) That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

&nbsp;&nbsp;&nbsp;&nbsp;(3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

B. The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual report pursuant to Section 13(a) or 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefits plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in this Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

C. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that, in the opinion of the Commission, such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.

------

**SIGNATURES**

Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Madison, State of Wisconsin, on July 11, 2025.

---

| | |
|:---|:---|
| EXACT SCIENCES CORPORATION | EXACT SCIENCES CORPORATION |
| By: | /s/ Kevin T. Conroy |
|  | Kevin T. Conroy |
|  | President, Chief Executive Officer and Chairman |

---

Pursuant to the requirements of the Securities Act of 1933, this Post-Effective Amendment has been signed by the following persons in the capacities and on the dates indicated.

------

---

| | | |
|:---|:---|:---|
| **Name** | **Title** | **Date** |
| /s/ Kevin T. Conroy | President, Chief Executive Officer and Chairman (Principal Executive Officer) | July 11, 2025 |
| Kevin T. Conroy |  |  |
| /s/ Aaron Bloomer | Executive Vice President and Chief Financial Officer (Principal Financial Officer and Principal Accounting Officer) | July 11, 2025 |
| Aaron Bloomer |  |  |
| /s/ Michael Barber | Director | July 11, 2025 |
| Michael Barber |  |  |
| /s/ Paul Clancy | Director | July 11, 2025 |
| Paul Clancy |  |  |
| /s/ D. Scott Coward | Director | July 11, 2025 |
| D. Scott Coward |  |  |
| /s/ James E. Doyle | Director | July 11, 2025 |
| James E. Doyle |  |  |
| /s/ Daniel J. Levangie | Director | July 11, 2025 |
| Daniel J. Levangie |  |  |
| /s/ Shacey Petrovic | Director | July 11, 2025 |
| Shacey Petrovic |  |  |
| /s/ Kimberly Popovits | Director | July 11, 2025 |
| Kimberly Popovits |  |  |
| /s/ Leslie Trigg | Director | July 11, 2025 |
| Leslie Trigg |  |  |
| /s/ Katherine S. Zanotti | Director | July 11, 2025 |
| Katherine S. Zanotti |  |  |

---

## Exhibit 5.1

**EXHIBIT 5.1**

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| | |
|:---|:---|
| ![image.jpg](image.jpg) | **K&L GATES LLP** <br>300 SOUTH TRYON STREET<br>SUITE 1000<br>CHARLOTTE, NC 28202<br>T +1 704 331 7400 F +1 704 331 7598 klgates.com |

---

July 11, 2025

Exact Sciences Corporation

5505 Endeavor Lane

Madison, WI 53719

Ladies and Gentlemen:

We have acted as special counsel to Exact Sciences Corporation, a Delaware corporation (the "<u>Company</u>") in connection with the preparation of a Post-Effective Amendment (the "<u>Post-Effective Amendment</u>"), to be filed by the Company with the Securities and Exchange Commission (the "<u>Commission</u>") on or about the date hereof, to the Registration Statement on Form S-8 (File No. 333-273572) (the "<u>Registration Statement</u>"), as filed by the Company with the Commission on August 1, 2023, in connection with the registration under the Securities Act of 1933, as amended (the "<u>Securities Act</u>"), of the Prior Plan Shares (as defined below) authorized for issuance under the Prior Plan (as defined below).

On June 12, 2025 (the "<u>Approval Date</u>"), the stockholders of the Company approved the Exact Sciences Corporation 2025 Omnibus Long-Term Incentive Plan (the "<u>2025 Plan</u>"). The total number of shares of the Company's common stock, par value $0.01 per share ("<u>Common Stock</u>") issuable under the 2025 Plan includes, in addition to the 11,896,525 newly available shares of Common Stock (less the number of shares of Common Stock the Registrant granted under the 2019 Plan between March 31, 2025 and June 12, 2025) (registered concurrently under the Securities Act pursuant to a new Registration Statement on Form S-8), the number of shares of Common Stock subject to stock options or other awards granted under the Exact Sciences Corporation 2010 Omnibus Long-Term Incentive Plan (As Amended and Restated Effective July 27, 2017) (the "<u>2010 Plan</u>") and the Exact Sciences Corporation 2019 Omnibus Long-Term Incentive Plan (as last amended on June 8, 2023, the "<u>2019 Plan</u>", and together with the 2010 Plan, the "<u>Prior Plans</u>") as of the Approval Date that expire or are terminated, surrendered or forfeited for any reason without the issuance of shares of Common Stock (the "<u>Prior Plan Shares</u>").

This opinion is being furnished in accordance with the requirements of Item 601(b)(5) of Regulation S-K under the Securities Act.

For purposes of rendering the opinion stated herein, we have examined (collectively, the "<u>Reviewed Documents</u>"):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the Registration Statement;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the 2025 Plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) the Prior Plans;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) the Sixth Amended and Restated Certificate of Incorporation of the Company as filed with the Secretary of State of the State of Delaware (the "<u>Secretary of State</u>") on February 5, 2001, as amended by the Certificate of Designations of Series A Junior Participating Preferred Stock of the Company as filed with the Secretary of State on February 23, 2011, as amended by the Certificate of Change of Location of Registered Office and of Registered Agent of the Company as filed with the Secretary of State on September 24, 2012, as amended by the Certificate of Amendment to Sixth Amended and Restated Certificate of Incorporation of the Company as filed with the Secretary of State of July 24, 2014, as amended by the Certificate of Elimination of Series A Junior Participating Preferred Stock of the Company as filed with the Secretary of State on October 25, 2018, as amended by the Certificate of Amendment to Sixth Amended and Restated Certificate of Incorporation of the Company as filed with the Secretary of State on July 23, 2020, as amended by the Certificate of Merger of Domestic Limited Liability Company into Domestic Corporation as filed with the Secretary of State on December 28, 2021, as amended by the Certificate of Ownership and Merger Merging Sampleminded, Inc. into the Company as filed with the

K&L GATES LLP

300 SOUTH TRYON STREET SUITE 1000 CHARLOTTE NC 28202

T +1 704 331 7400 F +1 704 331 7598 klgates.com

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Exact Sciences Corporation

July 11, 2025

Secretary of State on December 23, 2022, as amended by the Waiver of Requirement for Affidavit of Extraordinary Event Condition as filed with the Secretary of State on December 23, 2022, and as amended by the Certificate of Amendment to Sixth Amended and Restated Certificate of Incorporation of the Company as filed with the Secretary of State on June 9, 2023;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) the Seventh Amended and Restated By-Laws of the Company adopted effective as of June 9, 2023;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) resolutions adopted by the board of directors of the Company (the "<u>Board</u>") on April 15, 2025 approving the 2025 Plan, which authorizes the issuance of the Prior Plan Shares under the 2025 Plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) the minutes of the annual meeting of stockholders of the Company held on June 12, 2025 at which the stockholders of the Company approved the 2025 Plan; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) a certificate of an officer of the Company, dated the date hereof.

For purposes of rendering our opinion below, we have not reviewed any document other than the Reviewed Documents and assume there exists no provision in any document relating to the matters covered by our opinion below that we have not reviewed that is inconsistent with the Reviewed Documents or our opinion below. We have conducted no independent factual investigation of our own but rather have relied on the documents listed above, the statements and information set forth therein and the additional matters recited or assumed herein, all of which we assume to be true, complete and accurate in all respects.

For purposes of this opinion letter, we have made assumptions that are customary in opinion letters of this kind, including the assumptions that: (a) each of the Reviewed Documents is accurate and complete; (b) each of the Reviewed Documents that is an original is authentic; (c) each of the Reviewed Documents that is a copy conforms to an authentic original; (d) all signatures on each of the Reviewed Documents are genuine; and (e) there are no documents other than the Reviewed Documents that could affect the opinion expressed in this opinion letter and no amendments, modifications or waivers of the Reviewed Documents. We have further assumed (i) the legal capacity of natural persons, (ii) that each party to the Reviewed Documents (A) is duly organized, validly existing and in good standing under the laws of its organization, (B) has the legal capacity, power and authority to execute, deliver and perform its obligations under the Reviewed Documents to which it is a party, (C) has taken all action necessary to duly authorize the execution and delivery of, and the performance of such party's obligations under, the Reviewed Documents, and (D) has duly executed and delivered the Reviewed Documents, (iii) the Reviewed Documents constitute the legal, valid and binding obligation of each party thereto, enforceable against each such party in accordance with their terms, (iv) the issuance of the Prior Plan Shares will not increase the proportionate share of Common Stock held by an "interested stockholder" (within the meaning of Section 203(c) of the General Corporation Law of the State of Delaware (the "<u>DGCL</u>")), and (v) the Company is and shall remain at all times a corporation duly incorporated, validly existing and in good standing under the laws of the State of Delaware. We have not verified any of the foregoing assumptions.

In rendering our opinion below, we also have assumed that (a) the Company will have sufficient authorized, unissued and unreserved shares of Common Stock at the time of each issuance of a Prior Plan Share or rights or options to acquire a Prior Plan Share, in each case, under the 2025 Plan; (b) either (i) upon the issuance of a Prior Plan Share, such Prior Plan Share will be evidenced by a certificate that has been duly executed and delivered or (ii) the Board has adopted a resolution providing that all shares of Common Stock shall be uncertificated in accordance with Section 158 of the DGCL prior to the issuance of such Prior Plan Share and, within a reasonable time after the issuance of such uncertificated Prior Plan Share, the registered owner of such Prior Plan Share will be given notice in writing or by electronic transmission in compliance with Section 151(f) of the DGCL; (c) the issuance of each Prior Plan Share will be duly recorded in the Company's stock ledger upon its issuance; (d) the 2025 Plan and each Award Agreement (as defined in the 2025 Plan and hereinafter referred to as an "<u>Award Agreement</u>") constitutes or will constitute, as applicable, the valid and binding agreement of the Company, enforceable against the Company in accordance with its terms; (e) the Company will receive consideration for each Prior Plan Share as set forth in the applicable Authorizing Resolutions (as defined below), which consideration shall be at least equal to the par value of such share of Common Stock (unless such Prior Plan Share is held in treasury, in

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Exact Sciences Corporation

July 11, 2025

which case, the consideration shall be the amount as set forth in the applicable Authorizing Resolutions), and, in the amount required by the 2025 Plan and any applicable Award Agreement; (f) with respect to any Prior Plan Shares issuable upon the exercise of any right or option to acquire Prior Plan Shares under the 2025 Plan, the Company shall have received the minimum consideration (if any) for which such rights or options may be issued pursuant to the applicable Authorizing Resolutions and the 2025 Plan; and (g) prior to the issuance of any Prior Plan Shares or any right or option to acquire any Prior Plan Shares, in each case, under the 2025 Plan, the Board or a duly authorized committee of the Board will duly authorize by resolution each Award (as defined in the 2025 Plan) granted under the 2025 Plan with respect such Prior Plan Shares or rights or options to acquire such Prior Plan Shares and pursuant to an Award Agreement, in each case, in accordance with the DGCL and the 2025 Plan, (such resolutions, collectively, the "<u>Authorizing Resolutions</u>"). We have not verified any of the foregoing assumptions.

Our opinion set forth below is limited to the DGCL and reported decisions interpreting the DGCL. We express no opinion as to the laws, rules or regulations of any other jurisdiction, including, without limitation, the federal laws of the United States of America or any state securities or blue sky laws; we express no opinion with respect to the Corporate Transparency Act.

Based upon and subject to the foregoing and assuming that the Registration Statement will be effective at the time of such issuance, it is our opinion that the Prior Plan Shares, when and if issued and paid for in accordance with the terms of the 2025 Plan, the applicable Authorizing Resolutions and any applicable Award Agreements, will be validly issued, fully paid, and non-assessable.

We hereby consent to the filing of this opinion letter with the SEC as Exhibit 5.1 to the Post-Effective Amendment. In giving this consent, we do not thereby admit that we are experts with respect to any part of the Registration Statement within the meaning of the term "expert" as used in Section 11 of the Securities Act or the rules and regulations promulgated thereunder by the SEC, nor do we admit that we are within the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations of the SEC promulgated thereunder.

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|:---|
| Yours truly, |
| /s/ K&L Gates, LLP |
| K&L Gates LLP |

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## Exhibit 23.1

**EXHIBIT 23.1**

**CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM**

We hereby consent to the incorporation by reference in this Registration Statement on Form S-8 of Exact Sciences Corporation of our report dated February 19, 2025 relating to the financial statements and the effectiveness of internal control over financial reporting, which appears in Exact Sciences Corporation's Annual Report on Form 10-K for the year ended December 31, 2024.

/s/ PricewaterhouseCoopers LLP

Chicago, Illinois

July 11, 2025

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