# EDGAR Filing Document

**Accession Number:** 0001346824
**File Stem:** 0001104659-23-021803
**Filing Date:** 2023-2
**Character Count:** 22355
**Document Hash:** c8aea0cb33bc76d5f6ff92d74413ef04
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-23-021803.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001104659-23-021803

**CONFORMED SUBMISSION TYPE**: SC 13G/A

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**GROUP MEMBERS**: PETER KOLCHINSKY

**GROUP MEMBERS**: RA CAPITAL HEALTHCARE FUND, L.P.

**GROUP MEMBERS**: RAJEEV SHAH

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** PhaseBio Pharmaceuticals Inc
- **CENTRAL INDEX KEY:** 0001169245
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 030375697
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G/A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-90691
- **FILM NUMBER:** 23630728

**BUSINESS ADDRESS:**
- **STREET 1:** 1 GREAT VALLEY PARKWAY
- **STREET 2:** SUITE 30
- **CITY:** MALVERN
- **STATE:** PA
- **ZIP:** 19355
- **BUSINESS PHONE:** (610) 981-6500

**MAIL ADDRESS:**
- **STREET 1:** 1 GREAT VALLEY PARKWAY
- **STREET 2:** SUITE 30
- **CITY:** MALVERN
- **STATE:** PA
- **ZIP:** 19355

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Phase Biosciences Inc
- **DATE OF NAME CHANGE:** 20061013

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** DT BIOSCIENCES INC
- **DATE OF NAME CHANGE:** 20020315
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** RA CAPITAL MANAGEMENT, L.P.
- **CENTRAL INDEX KEY:** 0001346824
- **IRS NUMBER:** 830406777
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G/A

**BUSINESS ADDRESS:**
- **STREET 1:** 200 BERKELEY STREET, 18TH FLOOR
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02116
- **BUSINESS PHONE:** 617-778-2500

**MAIL ADDRESS:**
- **STREET 1:** 200 BERKELEY STREET, 18TH FLOOR
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02116

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** RA CAPITAL MANAGEMENT, LLC
- **DATE OF NAME CHANGE:** 20051213

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**WASHINGTON, D.C. 20549**

**SCHEDULE 13G/A**

**Under the Securities Exchange Act of 1934**

**(Amendment No. 2)\***

<u>PhaseBio Pharmaceuticals, Inc.</u>

(Name of Issuer)

<u>Common Stock, par value $0.001 per share</u>

(Title of Class of Securities)

<u>717224109</u>

(CUSIP Number)

___________<u>December 31, 2022</u>__________

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

◻ Rule 13d-1(b)

⌧ Rule 13d-1(c)

◻ Rule 13d-1(d)

\*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

CUSIP No. 717224109

---

| | | | |
|:---|:---|:---|:---|
| **1** | &nbsp;&nbsp;NAMES OF REPORTING PERSONS<br> I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)<br>RA Capital Management, L.P. | &nbsp;&nbsp;NAMES OF REPORTING PERSONS<br> I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)<br>RA Capital Management, L.P. | &nbsp;&nbsp;NAMES OF REPORTING PERSONS<br> I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)<br>RA Capital Management, L.P. |
| **2** | &nbsp;&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)<br> (a) ◻<br> (b) ◻ | &nbsp;&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)<br> (a) ◻<br> (b) ◻ | &nbsp;&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)<br> (a) ◻<br> (b) ◻ |
| **3** | &nbsp;&nbsp;SEC USE ONLY | &nbsp;&nbsp;SEC USE ONLY | &nbsp;&nbsp;SEC USE ONLY |
| **4** | &nbsp;&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware | &nbsp;&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware | &nbsp;&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware |
| NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | **5** | &nbsp;&nbsp;SOLE VOTING POWER<br>0<br>|
| NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | **6** | &nbsp;&nbsp;SHARED VOTING POWER<br>0<br>|
| NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | **7** | &nbsp;&nbsp;SOLE DISPOSITIVE POWER<br>0<br>|
| NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | **8** | &nbsp;&nbsp;SHARED DISPOSITIVE POWER<br>0<br>|
| **9** | &nbsp;&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>0 | &nbsp;&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>0 | &nbsp;&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>0 |
| **10** | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) ◻ | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) ◻ | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) ◻ |
| **11** | &nbsp;&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9<br>0% | &nbsp;&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9<br>0% | &nbsp;&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9<br>0% |
| **12** | &nbsp;&nbsp;TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)<br>IA, PN | &nbsp;&nbsp;TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)<br>IA, PN | &nbsp;&nbsp;TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)<br>IA, PN |

---

CUSIP No. 717224109

---

| | | | |
|:---|:---|:---|:---|
| **1** | &nbsp;&nbsp;NAMES OF REPORTING PERSONS<br> I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)<br>Peter Kolchinsky | &nbsp;&nbsp;NAMES OF REPORTING PERSONS<br> I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)<br>Peter Kolchinsky | &nbsp;&nbsp;NAMES OF REPORTING PERSONS<br> I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)<br>Peter Kolchinsky |
| **2** | &nbsp;&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)<br> (a) ◻<br> (b) ◻ | &nbsp;&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)<br> (a) ◻<br> (b) ◻ | &nbsp;&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)<br> (a) ◻<br> (b) ◻ |
| **3** | &nbsp;&nbsp;SEC USE ONLY | &nbsp;&nbsp;SEC USE ONLY | &nbsp;&nbsp;SEC USE ONLY |
| **4** | &nbsp;&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION<br>United States of America | &nbsp;&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION<br>United States of America | &nbsp;&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION<br>United States of America |
| NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | **5** | &nbsp;&nbsp;SOLE VOTING POWER<br>0<br>|
| NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | **6** | &nbsp;&nbsp;SHARED VOTING POWER<br>0<br>|
| NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | **7** | &nbsp;&nbsp;SOLE DISPOSITIVE POWER<br>0<br>|
| NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | **8** | &nbsp;&nbsp;SHARED DISPOSITIVE POWER<br>0<br>|
| **9** | &nbsp;&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>0 | &nbsp;&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>0 | &nbsp;&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>0 |
| **10** | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) ◻ | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) ◻ | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) ◻ |
| **11** | &nbsp;&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9<br>0% | &nbsp;&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9<br>0% | &nbsp;&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9<br>0% |
| **12** | &nbsp;&nbsp;TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)<br>HC, IN | &nbsp;&nbsp;TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)<br>HC, IN | &nbsp;&nbsp;TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)<br>HC, IN |

---

CUSIP No. 717224109

---

| | | | |
|:---|:---|:---|:---|
| **1** | &nbsp;&nbsp;NAMES OF REPORTING PERSONS<br> I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)<br>Rajeev Shah | &nbsp;&nbsp;NAMES OF REPORTING PERSONS<br> I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)<br>Rajeev Shah | &nbsp;&nbsp;NAMES OF REPORTING PERSONS<br> I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)<br>Rajeev Shah |
| **2** | &nbsp;&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)<br> (a) ◻<br> (b) ◻ | &nbsp;&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)<br> (a) ◻<br> (b) ◻ | &nbsp;&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)<br> (a) ◻<br> (b) ◻ |
| **3** | &nbsp;&nbsp;SEC USE ONLY | &nbsp;&nbsp;SEC USE ONLY | &nbsp;&nbsp;SEC USE ONLY |
| **4** | &nbsp;&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION<br>United States of America | &nbsp;&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION<br>United States of America | &nbsp;&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION<br>United States of America |
| NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | **5** | &nbsp;&nbsp;SOLE VOTING POWER<br>0<br>|
| NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | **6** | &nbsp;&nbsp;SHARED VOTING POWER<br>0<br>|
| NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | **7** | &nbsp;&nbsp;SOLE DISPOSITIVE POWER<br>0<br>|
| NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | **8** | &nbsp;&nbsp;SHARED DISPOSITIVE POWER<br>0<br>|
| **9** | &nbsp;&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>0 | &nbsp;&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>0 | &nbsp;&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>0 |
| **10** | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) ◻ | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) ◻ | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) ◻ |
| **11** | &nbsp;&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9<br>0% | &nbsp;&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9<br>0% | &nbsp;&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9<br>0% |
| **12** | &nbsp;&nbsp;TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)<br>HC, IN | &nbsp;&nbsp;TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)<br>HC, IN | &nbsp;&nbsp;TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)<br>HC, IN |

---

CUSIP No. 717224109

---

| | | | |
|:---|:---|:---|:---|
| **1** | &nbsp;&nbsp;NAMES OF REPORTING PERSONS<br> I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)<br>RA Capital Healthcare Fund, L.P. | &nbsp;&nbsp;NAMES OF REPORTING PERSONS<br> I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)<br>RA Capital Healthcare Fund, L.P. | &nbsp;&nbsp;NAMES OF REPORTING PERSONS<br> I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)<br>RA Capital Healthcare Fund, L.P. |
| **2** | &nbsp;&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)<br> (a) ◻<br> (b) ◻ | &nbsp;&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)<br> (a) ◻<br> (b) ◻ | &nbsp;&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)<br> (a) ◻<br> (b) ◻ |
| **3** | &nbsp;&nbsp;SEC USE ONLY | &nbsp;&nbsp;SEC USE ONLY | &nbsp;&nbsp;SEC USE ONLY |
| **4** | &nbsp;&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware | &nbsp;&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware | &nbsp;&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION<br>Delaware |
| NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | **5** | &nbsp;&nbsp;SOLE VOTING POWER<br>0<br>|
| NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | **6** | &nbsp;&nbsp;SHARED VOTING POWER<br>0<br>|
| NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | **7** | &nbsp;&nbsp;SOLE DISPOSITIVE POWER<br>0<br>|
| NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH: | **8** | &nbsp;&nbsp;SHARED DISPOSITIVE POWER<br>0<br>|
| **9** | &nbsp;&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>0 | &nbsp;&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>0 | &nbsp;&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>0 |
| **10** | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) ◻ | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) ◻ | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) ◻ |
| **11** | &nbsp;&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9<br>0% | &nbsp;&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9<br>0% | &nbsp;&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9<br>0% |
| **12** | &nbsp;&nbsp;TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)<br>PN | &nbsp;&nbsp;TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)<br>PN | &nbsp;&nbsp;TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)<br>PN |

---

---

| | |
|:---|:---|
| **Item 1(a).** | **<u>Name of Issuer</u>:** |

---

PhaseBio Pharmaceuticals, Inc. (the "Issuer")

---

| | |
|:---|:---|
| **Item 1(b).** | **<u>Address of Issuer's Principal Executive Offices</u>:** |

---

1 Great Valley Parkway, Suite 30, Malvern, PA 19355

---

| | |
|:---|:---|
| **Item 2(a).** | **<u>Names of Persons Filing</u>:** |

---

The names of the persons filing this report (collectively, the "Reporting Persons") are:

RA Capital Management, L.P. ("RA Capital")

Peter Kolchinsky

Rajeev Shah

RA Capital Healthcare Fund, L.P. (the "Fund")

---

| | |
|:---|:---|
| **Item 2(b).** | **<u>Address of Principal Business Office or, if None, Residence</u>:** |

---

The address of the principal business office of each of the Reporting Persons is:

c/o RA Capital Management, L.P., 200 Berkeley Street, 18<sup>th</sup> Floor, Boston MA 02116

---

| | |
|:---|:---|
| **Item 2(c).** | **<u>Citizenship</u>:** |

---

RA Capital and the Fund are Delaware limited partnerships. Dr. Kolchinsky and Mr. Shah are United States citizens.

---

| | |
|:---|:---|
| **Item 2(d).** | **<u>Title of Class of Securities</u>:** |

---

Common stock, par value $0.001 per share ("Common Stock")

---

| | |
|:---|:---|
| **Item 2(e).** | **<u>CUSIP Number</u>:** |

---

717224109

**Item 3.** **<u>If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:</u>**

Not applicable.

**Item 4.** **<u>Ownership</u>.**

Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

(a) Amount Beneficially Owned: See the response(s) to Item 9 on the attached cover page(s).

(b) Percent of Class: See the response(s) to Item 11 on the attached cover page(s).

(c) Number of shares as to which such person has:

(i) sole power to vote or to direct the vote: See the response(s) to Item 5 on the attached cover page(s).

(ii) shared power to vote or to direct the vote See the response(s) to Item 6 on the attached cover page(s).

(iii) sole power to dispose or to direct the disposition of See the response(s) to Item 7 on the attached cover page(s).

(iv) shared power to dispose or to direct the disposition of See the response(s) to Item 8 on the attached cover page(s).

**Item 5.** **<u>Ownership of Five Percent or Less of a Class</u>.**

If this statement is being filed to report the fact that as of the date hereof the Reporting Persons have ceased to be the beneficial owner of more than five percent of the class of securities, check the following ⌧.

**Item 6.** **<u>Ownership of More than Five Percent on Behalf of Another Person</u>.**

Not applicable.

**Item 7.** **<u>Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person</u>.**

Not applicable.

**Item 8.** **<u>Identification and Classification of Members of the Group</u>.**

Not applicable.

**Item 9.** **<u>Notice of Dissolution of Group</u>.**

Not applicable.

**Item 10.** **<u>Certification</u>.**

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

**<u>Exhibit List</u>**

Exhibit 1: Joint Filing Agreement

<u>SIGNATURE</u>

After reasonable inquiry and to the best of its knowledge and belief, each of the undersigned certifies that the information set forth in this statement is true, complete and correct.

---

| | | |
|:---|:---|:---|
| Date: February 14, 2023 | Date: February 14, 2023 | Date: February 14, 2023 |
| RA CAPITAL MANAGEMENT, L.P. | RA CAPITAL MANAGEMENT, L.P. | RA CAPITAL MANAGEMENT, L.P. |
| By: | /s/ Peter Kolchinsky | /s/ Peter Kolchinsky |
|  | Name: | Peter Kolchinsky |
|  | Title: | Authorized Signatory |
| PETER KOLCHINSKY | PETER KOLCHINSKY | PETER KOLCHINSKY |
| /s/ Peter Kolchinsky | /s/ Peter Kolchinsky | /s/ Peter Kolchinsky |
| RAJEEV SHAH | RAJEEV SHAH | RAJEEV SHAH |
| /s/ Rajeev Shah | /s/ Rajeev Shah | /s/ Rajeev Shah |
| RA CAPITAL HEALTHCARE FUND, L.P. | RA CAPITAL HEALTHCARE FUND, L.P. | RA CAPITAL HEALTHCARE FUND, L.P. |
| By: | RA Capital Healthcare Fund GP, LLC | RA Capital Healthcare Fund GP, LLC |
| Its: | General Partner | General Partner |
| By: | /s/ Peter Kolchinsky | /s/ Peter Kolchinsky |
|  | Name: | Peter Kolchinsky |
|  | Title: | Manager |

---

**EXHIBIT 1**

AGREEMENT

This Joint Filing Agreement, dated as of February 14, 2023, is by and among RA Capital Management, L.P., Peter Kolchinsky, Rajeev Shah, and RA Capital Healthcare Fund, L.P. (the foregoing are collectively referred to herein as the "Filers").

Each of the Filers may be required to file with the United States Securities and Exchange Commission a statement on Schedule 13G and/or 13D with respect to Common Stock $0.001 par value per share of PhaseBio Pharmaceuticals, Inc. beneficially owned by them from time to time.

Pursuant to and in accordance with Rule 13(d)(1)(k) promulgated under the Securities Exchange Act of 1934, as amended, the Filers hereby agree to file a single statement on Schedule 13G and/or 13D (and any amendments thereto) on behalf of each of such parties, and hereby further agree to file this Joint Filing Agreement as an exhibit to such statement, as required by such rule.

This Joint Filing Agreement may be terminated by any of the Filers upon one week's prior written notice or such lesser period of notice as the Filers may mutually agree.

Executed and delivered as of the date first above written.

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| | | |
|:---|:---|:---|
| RA CAPITAL MANAGEMENT, L.P. | RA CAPITAL MANAGEMENT, L.P. | RA CAPITAL MANAGEMENT, L.P. |
| By: | /s/ Peter Kolchinsky | /s/ Peter Kolchinsky |
|  | Name: | Peter Kolchinsky |
|  | Title: | Authorized Signatory |

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| | | |
|:---|:---|:---|
| PETER KOLCHINSKY | PETER KOLCHINSKY | PETER KOLCHINSKY |
| /s/ Peter Kolchinsky | /s/ Peter Kolchinsky | /s/ Peter Kolchinsky |
| RAJEEV SHAH | RAJEEV SHAH | RAJEEV SHAH |
| /s/ Rajeev Shah | /s/ Rajeev Shah | /s/ Rajeev Shah |
| RA CAPITAL HEALTHCARE FUND, L.P. | RA CAPITAL HEALTHCARE FUND, L.P. | RA CAPITAL HEALTHCARE FUND, L.P. |
| By: | RA Capital Healthcare Fund GP, LLC | RA Capital Healthcare Fund GP, LLC |
| Its: | General Partner | General Partner |
| By: | /s/ Peter Kolchinsky | /s/ Peter Kolchinsky |
|  | Name: | Peter Kolchinsky |
|  | Title: | Manager |

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