# EDGAR Filing Document

**Accession Number:** 0001400118
**File Stem:** 0001104659-26-046006
**Filing Date:** 2026-4
**Character Count:** 200902
**Document Hash:** eb10641bff28af766ee37aca828afce7
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-26-046006.hdr.sgml**: 20260421

**ACCESSION NUMBER**: 0001104659-26-046006

**CONFORMED SUBMISSION TYPE**: DEF 14A

**PUBLIC DOCUMENT COUNT**: 20

**CONFORMED PERIOD OF REPORT**: 20260612

**FILED AS OF DATE**: 20260421

**DATE AS OF CHANGE**: 20260421

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Sagimet Biosciences Inc.
- **CENTRAL INDEX KEY:** 0001400118
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 205991472
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** DEF 14A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-41742
- **FILM NUMBER:** 26879532

**BUSINESS ADDRESS:**
- **STREET 1:** 155 BOVET RD., SUITE 303
- **CITY:** SAN MATEO
- **STATE:** CA
- **ZIP:** 94402
- **BUSINESS PHONE:** (650) 561-8600

**MAIL ADDRESS:**
- **STREET 1:** 155 BOVET RD., SUITE 303
- **CITY:** SAN MATEO
- **STATE:** CA
- **ZIP:** 94402

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** 3-V Biosciences, Inc.
- **DATE OF NAME CHANGE:** 20070521

?xml version='1.0' encoding='ASCII'? tm261563-1_nonfiling - none - 7.2031728s

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### UNITED STATES SECURITIES AND EXCHANGE COMMISSION

#### Washington, D.C. 20549

### SCHEDULE 14A
Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

☒ Filed by the Registrant

☐ Filed by a Party other than the Registrant

Check the appropriate box:

#### ☐

#### Preliminary Proxy Statement

#### ☐

#### Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

#### ☒

#### Definitive Proxy Statement

#### ☐

#### Definitive Additional Materials

#### ☐

#### Soliciting Material under §240.14a-12
![[MISSING IMAGE: lg_sagimet-4c.jpg]](lg_sagimet-4c.jpg)

### SAGIMET BIOSCIENCES INC.
(Name of Registrant as Specified In Its Charter)

Payment of Filing Fee (Check all boxes that apply):

☒

**No fee required** 

☐

**Fee paid previously with preliminary materials** 

☐

**Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11**

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![[MISSING IMAGE: lg_sagimet-4c.jpg]](lg_sagimet-4c.jpg)

#### 155 Bovet Road, Suite 303 San Mateo, California 94402

#### 2026 ANNUAL MEETING OF STOCKHOLDERS To be Held on June 12, 2026
April 21, 2026

Dear Stockholder:

We are pleased to invite you to attend the 2026 Annual Meeting of Stockholders, or the Annual Meeting, of Sagimet Biosciences Inc., or the Company, we, us, which will be held at 9:30 a.m., Pacific Time, on Friday, June 12, 2026. The Annual Meeting will be held in virtual meeting format only. You will not be able to attend the Annual Meeting physically. We believe that the virtual meeting format enables stockholders to attend and participate from any location around the world at no cost, provides for cost savings and reduces the environmental impact of our Annual Meeting. The Annual Meeting can be accessed via the internet at https://web.lumiconnect.com/217605655, using the password sagimet2026.

Details regarding the business to be conducted at the Annual Meeting are more fully described in the accompanying Notice of 2026 Annual Meeting of Stockholders, or the Notice, and 2026 Annual Meeting Proxy Statement, or the Proxy Statement. Other than the proposals described in the Proxy Statement, our Board of Directors, or Board, is not aware of any other matters to be presented for a vote at the Annual Meeting. We are pleased to offer our proxy materials over the internet as permitted by Securities and Exchange Commission, or SEC, rules.

**Your vote is important**. Whether or not you plan to virtually attend the Annual Meeting, we encourage you to vote as soon as possible to ensure that your shares are represented. Information about voting methods is set forth in the accompanying Notice and Proxy Statement.

If you have any questions with respect to voting, please email our Chief Legal & Administrative Officer, Elizabeth Rozek, Esq., at legal@sagimet.com.

Sincerely,

---

| | |
|:---|:---|
| /s/ George Kemble, Ph.D. <br>George Kemble, Ph.D. <br> Chairman of the Board of Directors  | /s/ David Happel <br>David Happel <br> President and Chief Executive Officer  |

---

#### THIS PROXY STATEMENT AND ENCLOSED PROXY CARD ARE FIRST BEING MADE AVAILABLE TO STOCKHOLDERS ON OR ABOUT APRIL 21, 2026.

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![[MISSING IMAGE: lg_sagimet-4c.jpg]](lg_sagimet-4c.jpg)

#### NOTICE OF 2026 ANNUAL MEETING OF STOCKHOLDERS

#### To be Held on June 12, 2026

#### Dear Stockholders:
**NOTICE IS HEREBY GIVEN** that the 2026 Annual Meeting of Stockholders of Sagimet Biosciences Inc., or the Annual Meeting, will be held on Friday, June 12, 2026, at 9:30 a.m., Pacific Time. The Annual Meeting will be held in a virtual meeting format only. We are holding the meeting for the purpose of considering and acting upon:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 1.

The election of the four director nominees who are set forth in the attached 2026 Annual Meeting Proxy Statement, or the Proxy Statement, to serve as Class III directors whose term will expire in 2029;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 2.

The ratification of the appointment of KPMG LLP, or KPMG, as our independent registered public accounting firm for the 2026 fiscal year; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 3.

Any other matters that may properly be brought before the Annual Meeting or any adjournment or postponement thereof.

The foregoing items of business are more fully described in the Proxy Statement accompanying this Notice.

#### MEETING INFORMATION

---

| | |
|:---|:---|
| **Date: <br>**  | **June 12, 2026**  |
| **Time: <br>**  | **9:30 a.m., Pacific Time**  |
| **Website Address:**  | The meeting can be accessed by visiting https://web.lumiconnect.com/217605655 (password: sagimet2026), where you will be able to listen to the meeting live, submit questions and vote online. There will be no physical location for stockholders to attend. |
| **Record Date:** | **You can vote if you were a stockholder of record on April 17, 2026.**  |

---

 ***Your vote matters**. Whether or not you plan to virtually attend the Annual Meeting, please ensure that your shares are represented by voting, signing, dating and returning your proxy in the enclosed envelope, which requires no postage if mailed in the United States.* 

By Order of the Board of Directors,

/s/ Elizabeth Rozek, Esq.

Elizabeth Rozek, Esq.

*Chief Legal & Administrative Officer*

April 21, 2026

 **IMPORTANT NOTICE REGARDING AVAILABILITY OF PROXY MATERIALS. This Proxy Statement and the proxy card are being furnished to our stockholders on or about April 21, 2026. This Proxy Statement and our Annual Report on Form 10-K for the fiscal year ended December 31, 2025, or the 2025 Annual Report, are available to holders of our common stock at www.astproxyportal.com/ast/27458. If you would like to receive, without charge, a paper copy of our 2025 Annual Report, including the financial statements therein, please send your request to: Chief Legal & Administrative Officer, Sagimet Biosciences Inc., 155 Bovet Road, Suite 303, San Mateo, California 94402.** 

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#### SUMMARY INFORMATION
This summary highlights information contained elsewhere in this Proxy Statement and our Annual Report on Form 10-K for the fiscal year ended December 31, 2025, or the 2025 Annual Report. This summary does not contain all of the information you should consider and we encourage you to read this Proxy Statement and the 2025 Annual Report carefully before voting.

#### 2026 Annual Meeting of Stockholders

---

| | | |
|:---|:---|:---|
| **TIME AND DATE**  | **RECORD DATE**  | **WEBSITE ADDRESS**  |
| Friday, June 12, 2026 9:30 a.m., Pacific Time | April 17, 2026  | The meeting can be accessed by visiting https://web.lumiconnect.com/217605655 (password: sagimet2026), where you will be able to listen to the meeting live, submit questions and vote online. There will be no physical location for stockholders to attend.  |

---

#### Summary of Stockholder Voting Matters

---

| | | |
|:---|:---|:---|
| **VOTING MATTERS**  | **FOR MORE <br> INFORMATION**  | **BOARD OF DIRECTORS <br> RECOMMENDATION**  |
| **PROPOSAL 1**: Election of Class III Directors for a Three-Year Term Expiring in 2029 | Page [40](#P1EO)  | ✓ FOR Each Nominee  |
| Jennifer Jarrett Anne Phillips, M.D. <br> David Happel George Kemble, Ph.D. | Jennifer Jarrett Anne Phillips, M.D. <br> David Happel George Kemble, Ph.D. | Jennifer Jarrett Anne Phillips, M.D. <br> David Happel George Kemble, Ph.D. |
| **PROPOSAL 2**: Ratification of Appointment of KPMG as our Independent Registered Public Accounting Firm for 2026 | Page [41](#P2RO)  | ✓ FOR  |

---

#### Our Director Nominees
You are being asked to vote on the election of Jennifer Jarrett, Anne Phillips, M.D., David Happel and George Kemble, Ph.D. as Class III directors, each to serve for a three-year term expiring at our 2029 Annual Meeting of Stockholders, or the 2029 Annual Meeting. The number of members of our board of directors, or Board, is currently set at eight members. Our Board is divided into three classes, each of which has a three-year term. Class I currently consists of two directors, Class II consists of two directors and Class III consists of four directors.

The term of office of our Class III directors, Jennifer Jarrett, Anne Phillips, M.D., David Happel and George Kemble, Ph.D., expires at the Annual Meeting.

We are nominating Jennifer Jarrett, Anne Phillips, M.D., David Happel and George Kemble, Ph.D. for re-election as Class III directors at our Annual Meeting to serve until the 2029 Annual Meeting and until their successors, if any, are elected or appointed, or their earlier death, resignation, retirement, disqualification or removal. Directors are elected by a plurality of the votes properly cast by our stockholders at the Annual Meeting. The nominees receiving the most FOR votes (among votes properly cast online at the meeting or by proxy) will be elected. If no contrary indication is made, shares represented by executed proxies will be voted FOR the election of Jennifer Jarrett, Anne Phillips, M.D., David Happel and George Kemble, Ph.D. Each nominee has agreed to serve as a director if elected, and we have no reason to believe that any nominee will be unable to serve.

i

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---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| **NAME**  | **AGE\***  | **DIRECTOR <br> SINCE**  | **OCCUPATION**  | **INDEPENDENT**  | **COMMITTEE <br> MEMBERSHIPS**  | **COMMITTEE <br> MEMBERSHIPS**  | **COMMITTEE <br> MEMBERSHIPS**  |
| **NAME**  | **AGE\***  | **DIRECTOR <br> SINCE**  | **OCCUPATION**  | **INDEPENDENT**  | **AC**  | **CC**  | **NCGC**  |
| Jennifer Jarrett | 55 | 2024 | Chief Executive Officer, <br> Damora Therapeutics  | Yes | &nbsp;&nbsp; M |  |  |
| Anne Phillips, M.D. | 72 | 2007 | Retired  | Yes |  | &nbsp;&nbsp; M | &nbsp;&nbsp; M |
| David Happel | 64 | 2022 | Chief Executive Officer, <br> Sagimet Biosciences Inc.  | No |  |  |  |
| George Kemble, Ph.D. | 65 | 2015 | Chairman of the Board, <br> Sagimet Biosciences Inc.  | No |  |  |  |

---

---

| | | |
|:---|:---|:---|
| **AC = Audit Committee** | **CC = Compensation Committee** | **C = Chair** |
| **NCGC = Nominating and Corporate Governance Committee** | **NCGC = Nominating and Corporate Governance Committee** | **M = Member** |

---

\*

Age as of the Annual Meeting.

#### CORPORATE GOVERNANCE HIGHLIGHTS
The following table summarizes our current Board structure and key elements of our corporate governance framework:

---

| | |
|:---|:---|
| **GOVERNANCE ITEMS**  | **GOVERNANCE ITEMS**  |
| Size of Board (set by the Board) | 8  |
| Number of Independent Directors | 6  |
| Board Self-Evaluation | Annual  |
| Review of Independence of Board | Annual  |
| Independent Directors Meet Without Management Present | Yes  |
| Voting Standard for Election of Directors in Uncontested Elections | Plurality  |
| Diversity of Board background, gender, experience and skills | Yes  |

---

#### RECENT CORPORATE HIGHLIGHTS
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • In January 2026, positive topline results were reported by our license partner for China, Ascletis BioScience Co. Ltd. (Ascletis) in the open-label Phase 3 trial evaluating the long-term safety of ASC40 (denifanstat) tablets in patients with moderate to severe acne in China.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • In December 2025, China's National Medical Products Administration (NMPA) accepted Ascletis' New Drug Application (NDA) for denifanstat for the treatment of moderate to severe acne.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • In December 2025, we announced completion of our Phase 1 pharmacokinetic trial of a combination of denifanstat and resmetirom. The combination of denifanstat and resmetirom was generally well-tolerated over the duration of the study, with no safety signals. No SAEs were reported, and there were no clinically significant laboratory AEs and no treatment-related discontinuations.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • In August 2025, we entered into a Sales Agreement with Leerink Partners LLC to establish an at-the-market offering, through which we may sell, from time to time at our sole discretion, up to $75.0 million shares of our Series A common stock.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • In June 2025, we initiated a first-in-human Phase 1 clinical trial of our potent and selective small molecule fatty acid synthase inhibitor, TVB-3567, for development of an acne indication.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • In June 2025, Ascletis announced that denifanstat met all primary and secondary endpoints in its Phase 3 trial in moderate to severe acne vulgaris in China.

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#### **TABLE OF CONTENTS**

---

| | |
|:---|:---|
| [SUMMARY INFORMATION](#SUIN)  | [i](#SUIN) |
| &nbsp;&nbsp;&nbsp; [CORPORATE GOVERNANCE HIGHLIGHTS](#CGH)  | [ii](#CGH) |
| &nbsp;&nbsp;&nbsp; [RECENT CORPORATE HIGHLIGHTS](#RCH)  | [ii](#RCH) |
| &nbsp;&nbsp;&nbsp; [PROXY STATEMENT](#PRST)  | [iv](#PRST) |
| [GENERAL INFORMATION ABOUT THE MEETING](#GIAT)  | [1](#GIAT) |
| &nbsp;&nbsp;&nbsp; [PROXY SOLICITATION](#PRSO)  | [1](#PRSO) |
| &nbsp;&nbsp;&nbsp; [STOCKHOLDERS ENTITLED TO VOTE](#SETV)  | [1](#SETV) |
| &nbsp;&nbsp;&nbsp; [VOTING METHODS](#VOME)  | [1](#VOME) |
| &nbsp;&nbsp;&nbsp; [HOW YOUR SHARES WILL BE VOTED](#HYSW)  | [1](#HYSW) |
| &nbsp;&nbsp;&nbsp; [BROKER VOTING AND VOTES REQUIRED FOR EACH PROPOSAL](#BVAV)  | [2](#BVAV) |
| &nbsp;&nbsp;&nbsp; [QUORUM](#QUO)  | [2](#QUO) |
| &nbsp;&nbsp;&nbsp; [PROXY SOLICITATION COSTS](#PSC)  | [2](#PSC) |
| [BOARD OF DIRECTORS](#BOD)  | [3](#BOD) |
| &nbsp;&nbsp;&nbsp; [BOARD STRUCTURE AND COMPOSITION](#BSAC)  | [3](#BSAC) |
| &nbsp;&nbsp;&nbsp; [CRITERIA FOR BOARD MEMBERSHIP](#CFBM)  | [3](#CFBM) |
| &nbsp;&nbsp;&nbsp; [SELECTION OF CANDIDATES](#SOC)  | [4](#SOC) |
| &nbsp;&nbsp;&nbsp; BOARD DIVERSITY  |  |
| &nbsp;&nbsp;&nbsp; [BOARD OVERSIGHT OF COMPANY CULTURE AND ENVIRONMENTAL, SOCIAL AND <br> GOVERNANCE HIGHLIGHTS](#BOOC)  | [4](#BOOC) |
| &nbsp;&nbsp;&nbsp; [DIRECTOR NOMINEES](#DINO)  | [5](#DINO) |
| &nbsp;&nbsp;&nbsp; [CONTINUING DIRECTORS](#CODI)  | [8](#CODI) |
| [CORPORATE GOVERNANCE AND RISK MANAGEMENT](#CGAR)  | [11](#CGAR) |
| &nbsp;&nbsp;&nbsp; [BOARD INDEPENDENCE](#BOIN)  | [11](#BOIN) |
| &nbsp;&nbsp;&nbsp; [BOARD LEADERSHIP STRUCTURE AND THE BOARD'S ROLE IN RISK OVERSIGHT](#BLSA)  | [11](#BLSA) |
| &nbsp;&nbsp;&nbsp; [BOARD COMMITTEES](#BOCO)  | [12](#BOCO) |
| &nbsp;&nbsp;&nbsp; [EVALUATING BOARD EFFECTIVENESS](#EBE)  | [12](#EBE) |
| &nbsp;&nbsp;&nbsp; [CODE OF BUSINESS CONDUCT AND ETHICS](#COBC)  | [12](#COBC) |
| &nbsp;&nbsp;&nbsp; [DIRECTOR ORIENTATION AND CONTINUING EDUCATION](#DOAC)  | [12](#DOAC) |
| &nbsp;&nbsp;&nbsp; [CORPORATE GOVERNANCE GUIDELINES](#CGG)  | [12](#CGG) |
| &nbsp;&nbsp;&nbsp; [COMPENSATION CONSULTANT](#COCO)  | [16](#COCO) |
| &nbsp;&nbsp;&nbsp; [COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION](#CCIA)  | [16](#CCIA) |
| &nbsp;&nbsp;&nbsp; [FAMILY RELATIONSHIPS](#FARE)  | [16](#FARE) |
| &nbsp;&nbsp;&nbsp; [STOCKHOLDER ENGAGEMENT](#STEN)  | [17](#STEN) |
| [DIRECTOR COMPENSATION](#DICO)  | [18](#DICO) |
| &nbsp;&nbsp;&nbsp; [2025 DIRECTOR COMPENSATION TABLE](#TFTB)  | [19](#TFTB) |
| [INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM](#IRPA)  | [20](#IRPA) |
| &nbsp;&nbsp;&nbsp; [INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FEES](#IRPA1)  | [20](#IRPA1) |
| &nbsp;&nbsp;&nbsp; [AUDIT COMMITTEE PRE-APPROVAL POLICIES AND PROCEDURES](#ACPP)  | [20](#ACPP) |
| [AUDIT COMMITTEE REPORT](#ACR)  | [22](#ACR) |
| [EXECUTIVE OFFICERS](#EXOF)  | [23](#EXOF) |
| [EXECUTIVE COMPENSATION](#EXCO)  | [24](#EXCO) |
| [CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS](#CRAR)  | [36](#CRAR) |

---

iii

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---

| | |
|:---|:---|
| [EQUITY COMPENSATION PLAN INFORMATION](#ECPI)  | [37](#ECPI) |
| [SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT](#SOOC)  | [38](#SOOC) |
| [ITEMS TO BE VOTED ON](#ITBV)  | [40](#ITBV) |
| &nbsp;&nbsp;&nbsp; [PROPOSAL 1: ELECTION OF CLASS III DIRECTORS FOR A THREE-YEAR TERM EXPIRING IN 2029](#P1EO)  | [40](#P1EO) |
| &nbsp;&nbsp;&nbsp; [PROPOSAL 2: RATIFICATION OF APPOINTMENT OF KPMG LLP AS OUR INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR 2026](#P2RO)  | [41](#P2RO) |
| [OTHER INFORMATION](#OTIN)  | [42](#OTIN) |
| &nbsp;&nbsp;&nbsp; [OTHER MATTERS](#OTMA)  | [42](#OTMA) |
| &nbsp;&nbsp;&nbsp; [REQUIREMENTS FOR SUBMISSION OF STOCKHOLDER PROPOSALS FOR NEXT YEAR'S ANNUAL MEETING](#RFSO)  | [42](#RFSO) |
| &nbsp;&nbsp;&nbsp; [STOCKHOLDER COMMUNICATIONS TO THE BOARD](#SCTT)  | [42](#SCTT) |
| &nbsp;&nbsp;&nbsp; [AVAILABILITY OF MATERIALS](#AOM)  | [43](#AOM) |

---

#### PROXY STATEMENT
This Proxy Statement, with the enclosed proxy card, is being mailed to stockholders of the Company in connection with the solicitation by our Board of proxies to be voted at our Annual Meeting and at any postponements or adjournments thereof. The Annual Meeting will be held on Friday, June 12, 2026, at 9:30 a.m., Pacific Time, via the internet at https://web.lumiconnect.com/217605655, using the password sagimet2026.

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#### GENERAL INFORMATION ABOUT THE MEETING

#### PROXY SOLICITATION
 **Our Board is soliciting your vote on matters that will be presented at the Annual Meeting and at any adjournment or postponement thereof. This Proxy Statement contains information on these matters to assist you in voting your shares.** 

This Proxy Statement and the proxy card are being mailed to our stockholders on or about April 28, 2026. This Proxy Statement and our 2025 Annual Report are available to holders of our Series A common stock at www.astproxyportal.com/ast/27458. If you would like to receive, without charge, a paper copy of our 2025 Annual Report, including the financial statements, please send your request to: Chief Legal & Administrative Officer, Sagimet Biosciences Inc., 155 Bovet Road, Suite 303, San Mateo, California 94402.

#### STOCKHOLDERS ENTITLED TO VOTE
All stockholders of record of our Series A common stock at the close of business on April 17, 2026, or the Record Date, are entitled to receive the Notice and to vote their shares at the Annual Meeting. As of that date, 32,017,613 shares of our Series A common stock were outstanding. Each share is entitled to one vote on each matter properly brought to the meeting. Holders of our Series B common stock are not entitled to vote on any matters that will come before the Annual Meeting.

#### VOTING METHODS
You may cast your vote in any of the following ways:

---

| | | | |
|:---|:---|:---|:---|
| ![[MISSING IMAGE: ic_mail-4c.jpg]](ic_mail-4c.jpg)  | ![[MISSING IMAGE: ic_internet-4c.jpg]](ic_internet-4c.jpg)  | ![[MISSING IMAGE: ic_telephone-4c.jpg]](ic_telephone-4c.jpg)  | ![[MISSING IMAGE: ic_laptop-4c.jpg]](ic_laptop-4c.jpg)  |
| **MAIL**  | **INTERNET**  | **PHONE**  | **DURING THE <br> MEETING**  |
| Mailing your signed proxy card or voter instruction card.  | Using the internet at www.voteproxy.com and follow the on-screen instructions.  | Calling toll-free from the United States, U.S. territories to 1-800-PROXIES and foreign countries to 1-201-299-4446.  | You can vote at the meeting at https://web.lumiconnect.com/217605655 (password: sagimet2026) |

---

#### HOW YOUR SHARES WILL BE VOTED
In each case, your shares will be voted as you instruct. If you return a signed card, but do not provide voting instructions, your shares will be voted FOR each of the proposals. If you are the record holder of your shares, you may revoke or change your vote any time before the proxy is exercised. To do so, you must do one of the following:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • Vote over the internet or by telephone as instructed above. Only your latest internet or telephone vote is counted. You may not revoke or change your vote over the internet or by telephone after 11:59 p.m. Eastern Time, or 8:59 p.m. Pacific Time, on June 11, 2026.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • Sign a new proxy card and submit it by mail, which must be received no later than June 11, 2026. Only your latest dated proxy card will be counted.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • Give our Corporate Secretary written notice before or during the meeting that you want to revoke your proxy.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • Virtually attend the Annual Meeting at https://web.lumiconnect.com/217605655, using the password sagimet2026.

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Virtually attending the Annual Meeting will not by itself revoke a previously granted proxy.

If your shares are held by your broker, bank or other holder of record as a nominee or agent (i.e., the shares are held in street name), you should follow the instructions provided by your broker, bank or other holder of record.

*Deadline for Voting*. The deadline for voting by telephone or internet, other than by virtually attending the Annual Meeting, is 11:59 p.m. Eastern Time, or 8:59 p.m. Pacific Time, on June 11, 2026. If you are a registered stockholder and virtually attend the Annual Meeting, you may deliver your vote online during the Annual Meeting. "Street name" stockholders who wish to vote at the Annual Meeting will need to obtain a proxy form from the institution that holds their shares.

#### BROKER VOTING AND VOTES REQUIRED FOR EACH PROPOSAL
If your shares are held in a stock brokerage account or by a bank or other holder of record, you are considered the beneficial owner of shares held in street name. The Notice has been forwarded to you by your broker, bank or other holder of record who is considered the stockholder of record of those shares. As the beneficial owner, you may direct your broker, bank or other holder of record on how to vote your shares by using the proxy card included in the materials made available or by following their instructions for voting on the internet.

A broker non-vote occurs when a broker or other nominee that holds shares for another does not vote on a particular item because the nominee does not have discretionary voting authority for that item and has not received instructions from the beneficial owner of the shares. The following table summarizes how votes withheld, broker non-votes and abstentions are treated with respect to our proposals:

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| | | | |
|:---|:---|:---|:---|
| **VOTING MATTERS**  | **VOTES <br> REQUIRED**  | **TREATMENT OF <br> ABSTENTIONS AND <br> BROKER NON-VOTES**  | **BROKER <br> DISCRETIONARY <br> VOTING**  |
| **PROPOSAL 1**: Election of Class III <br> Directors for a Three-Year Term Expiring <br> in 2029  | Plurality of the <br> votes properly cast  | Votes withheld and <br> broker non-votes will <br> have no effect on the <br> outcome of the <br> proposal  | No  |
| **PROPOSAL 2**: Ratification of <br> Appointment of KPMG as our <br> Independent Registered Public Accounting <br> Firm for 2026  | Majority of the <br> votes properly cast  | Abstentions and <br> broker non-votes will <br> have no effect on the <br> outcome of the <br> proposal  | Yes  |

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#### QUORUM
We must have a quorum to conduct business at the Annual Meeting. A quorum consists of the presence at the Annual Meeting, either attending the meeting virtually or represented by proxy, of the holders of shares of capital stock entitled to vote representing a majority of the voting power of all outstanding shares of capital stock entitled to vote. Holders of Series B common stock are not entitled to vote on any matters that will come before the Annual Meeting and therefore will not be considered for the purpose of determining the presence or absence of a quorum. For the purpose of establishing a quorum, votes withheld, abstentions, including brokers holding customers' shares of record who cause abstentions to be recorded at the meeting, and broker non-votes count toward the quorum. If there is no quorum, the holders of shares of capital stock entitled to vote representing a majority of the voting power virtually attending the Annual Meeting or represented by proxy or the presiding officer of the meeting may adjourn the Annual Meeting to another date.

#### PROXY SOLICITATION COSTS
We pay the cost of soliciting proxies. Proxies will be solicited on behalf of the Board by mail, telephone, and other electronic means or in person. Directors and employees will not be paid any additional compensation for soliciting proxies. We may reimburse brokerage firms, banks and other agents for the cost of forwarding proxy materials to beneficial owners.

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#### BOARD OF DIRECTORS
Our Board consists of eight directors divided into three classes, with each class holding office for a three-year term. Each of Jennifer Jarrett, Anne Phillips, M.D., David Happel and George Kemble, Ph.D., current Class III directors, have been nominated by our Board for election at the Annual Meeting for a three-year term that will expire at the 2029 Annual Meeting and until their successors, if any, are elected or appointed, or their earlier death, resignation, retirement, disqualification or removal. Each of the nominees has agreed to be named and to serve, and we expect each nominee to be able to serve if elected. If any nominee is unable to serve, the nominating and corporate governance committee of the Board, or the Nominating and Corporate Governance Committee, will recommend to our Board a replacement nominee. The Board may then designate the other nominee to stand for election. If you voted for the unavailable nominee, your vote will be cast for his or her replacement.

The number of members of our Board is currently set at eight members. The term of office of our Class III directors, Jennifer Jarrett, Anne Phillips, M.D., David Happel and George Kemble, Ph.D., expires at the Annual Meeting.

#### BOARD STRUCTURE AND COMPOSITION
Our business and affairs are managed under the direction of our Board, which currently consists of eight members. The primary responsibilities of our Board are to provide oversight, strategic guidance, counseling and direction to our management. Our Board meets on a regular basis and additionally as required. Our Eleventh Amended and Restated Certificate of Incorporation, or Charter, and Second Amended and Restated Bylaws, or Bylaws, permit our Board to establish the authorized number of directors from time to time by resolution. Each director serves until the expiration of the term for which such director was elected or appointed, or until such director's earlier death, resignation or removal. In accordance with our Charter, our Board is divided into three classes with staggered three-year terms. At each annual meeting of stockholders, the successors to directors whose terms then expire will be elected to serve from the time of election and qualification until the third annual meeting following election. Our directors are divided among the three classes as follows:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • the Class I directors are Timothy P. Walbert and Paul Hoelscher and their terms will expire at the annual meeting of stockholders to be held in 2027;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • the Class II directors are Elizabeth Grammer, Esq. and Beth Seidenberg, M.D. and their terms will expire at the annual meeting of stockholders to be held in 2028; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • the Class III directors are Jennifer Jarrett, Anne Phillips, M.D., David Happel and George Kemble, Ph.D. and their terms will expire at the Annual Meeting.

Dr. Seidenberg and Dr. Kemble were initially elected to our Board pursuant to the Amended and Restated Voting Agreement we entered into in December 2020 with certain investors which terminated upon the closing of our initial public offering, or IPO.

#### CRITERIA FOR BOARD MEMBERSHIP
The Nominating and Corporate Governance Committee has identified certain criteria that it considers in identifying director nominees. Important general criteria and considerations for Board membership include:

#### GENERAL CRITERIA
✓ Relevant experience and expertise

✓ Proven achievement and competence in such individual's field

✓ Sound business judgment

✓ An understanding of the fiduciary responsibilities required of a director

✓ Willingness and ability to devote sufficient time to Board responsibilities

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✓ Commitment to devoting time and energy to our affairs

✓ Diverse personal background, perspective and experience

The Nominating and Corporate Governance Committee also considers, on an ongoing basis, the background, experience and skills of the incumbent directors that are important to our current and future business needs and evaluates the experience and skills that would be valuable in new Board members.

#### SELECTION OF CANDIDATES

#### Director Skill Set Considerations
The Nominating and Corporate Governance Committee considers a wide range of factors including each director or candidate's skill sets, other boards of directors on which he or she serves, other positions he or she holds, and the independence of each director and candidate, to ensure that a substantial majority of the Board is independent.

#### Potential Director Candidates
On an ongoing basis, the Nominating and Corporate Governance Committee considers potential director candidates identified on its own initiative, as well as candidates referred or recommended to it by other directors, members of management, search firms, stockholders and others (including individuals seeking to join the Board). Stockholders who wish to recommend candidates may contact the Nominating and Corporate Governance Committee in the manner described in "Stockholder Communications to the Board" in this Proxy Statement. Stockholder nominations must be made according to the procedures required under our Bylaws and described in this Proxy Statement under the heading "Requirements for Submission of Stockholder Proposals for Next Year's Annual Meeting." Stockholder-recommended candidates and stockholder nominees whose nominations comply with these procedures and who meet the criteria referred to above will be evaluated by the Nominating and Corporate Governance Committee in the same manner as the Board's nominees.

#### BOARD OVERSIGHT OF COMPANY CULTURE AND ENVIRONMENTAL, SOCIAL AND GOVERNANCE HIGHLIGHTS
Our Board is committed to fostering a strong culture of compliance and ethical conduct and has structured its committees and their activities to support its commitment. Our Board supports management in ensuring that our culture and strategy are aligned and in promoting a corporate culture of integrity, ethical behavior and compliance with laws and regulations . Our Board expects all directors, as well as officers and employees, to conduct themselves in a manner consistent with our Code of Business Conduct and Ethics, or the Code of Conduct, and our values. Our Board believes that a strong culture of integrity, ethics and compliance is fundamental to the conduct of our business, and is necessary for effective risk management, maintaining investor trust, and successful corporate governance.

We understand corporate responsibility is essential for good governance because it strengthens the accountability of our Board and management team. We view Environmental, Social and Governance, or ESG, initiatives as long-term value drivers for the Company and our stockholders. Our focus on and commitment to ESG is tied to our belief that achieving and sustaining business excellence goes hand-in-hand with strong corporate leadership and stewardship. Our Board is primarily responsible for overseeing our corporate strategy, which includes the oversight of ESG matters that impact our business and related risks. Though our current ESG initiatives are broad, we continue to focus on our people, culture and strong corporate governance.

The following is a summary of our current ESG policies and practices:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • **Independent Committees:** Each of our Board committees consists entirely of independent directors.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • **Regularly Held Executive Sessions:** The independent directors of our Board meet separately in executive session on a regular basis to discuss matters relating to the Company and the Board, without members of the management team present.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • **Code of Conduct:** All of our directors, officers and employees are subject to the Code of Conduct, which is available on the "Investors & Media" — "Corporate Governance" section of our website at www.sagimet.com.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • **Human Capital Management:** We are committed to the health and welfare of our employees. We support the development of our employees with a competitive compensation and benefits package, internal advancement, and individualized development opportunities.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • **Diversity and Inclusion**: We strive to create a workplace culture that supports a diverse, multi-cultural workforce, treats individuals fairly, and provides an inclusive environment where everyone can bring their whole self to work and feel supported in reaching their full potential.

In each of the director nominee and continuing director biographies that follow, we highlight the specific experience, qualifications, attributes and skills that led the Board to conclude that the director nominee or continuing director should serve on our Board at this time.

#### DIRECTOR NOMINEES

#### CLASS III DIRECTORS — PRESENT TERMS EXPIRING AT THE ANNUAL MEETING AND PROPOSED TERMS TO EXPIRE IN 2029

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| **JENNIFER JARRETT** | **JENNIFER JARRETT** | **JENNIFER JARRETT** |
| **Age: 55 <br> Director Since: 2024**  | **Committee Memberships: Audit**  | **Other Public Directorships**: Syndax Pharmaceuticals, Inc., Zura Bio Ltd. |
| **Jennifer Jarrett** has served as a member of our Board since August 2024. Ms. Jarrett currently serves as the President, Chief Executive Officer and board director at Damora Therapeutics (Nasdaq: DMRA). From 2021 until March 2026, she served as Chief Operating Officer of Arcus Biosciences, Inc., or Arcus, a clinical-stage, global biopharmaceutical company, and previously served on the board of directors of Arcus from January 2019 until January 2024. Prior to joining Arcus as Chief Operating Officer, Ms. Jarrett served as Vice President, Corporate Development and Capital Markets at Uber, Inc., a technology company providing a platform for mobility, delivery and freight services, from January 2019 to 2021 and prior to that, served as Arcus' Chief Operating and Financial Officer from March 2017 to January 2019. From April 2016 to October 2016, Ms. Jarrett was the Chief Financial Officer of Medivation, Inc., a biopharmaceutical company, which was acquired by Pfizer Inc. Prior to that, Ms. Jarrett spent 20 years in investment banking, most recently as Managing Director at Citigroup from July 2010 to March 2016, where she was responsible for managing their west coast life sciences investment banking practice. Ms. Jarrett currently serves on the board of directors of Damora Therapeutics, Zura Bio Ltd (Nasdaq: ZURA), Syndax Pharmaceuticals, Inc. (Nasdaq: SNDX), and LifeMine Therapeutics, Inc. Ms. Jarrett previously served on the boards of directors of Arena Pharmaceuticals, Inc. from July 2017 until its acquisition by Pfizer in March 2022, Audentes Therapeutics from July 2017 until its acquisition by Astellas Pharma Inc. in January 2020, Radius Health, Inc. from May 2022 until its acquisition by Gurnet Point Capital and Patient Square Capital in August 2022, and Consonance-HFW Acquisition Corp. from December 2020 until its business combination with Surrozen Operating, Inc. in August 2021. Ms. Jarrett holds a B.A. in Economics, cum laude, from Dartmouth College and an M.B.A. from Stanford Graduate School of Business. | **Jennifer Jarrett** has served as a member of our Board since August 2024. Ms. Jarrett currently serves as the President, Chief Executive Officer and board director at Damora Therapeutics (Nasdaq: DMRA). From 2021 until March 2026, she served as Chief Operating Officer of Arcus Biosciences, Inc., or Arcus, a clinical-stage, global biopharmaceutical company, and previously served on the board of directors of Arcus from January 2019 until January 2024. Prior to joining Arcus as Chief Operating Officer, Ms. Jarrett served as Vice President, Corporate Development and Capital Markets at Uber, Inc., a technology company providing a platform for mobility, delivery and freight services, from January 2019 to 2021 and prior to that, served as Arcus' Chief Operating and Financial Officer from March 2017 to January 2019. From April 2016 to October 2016, Ms. Jarrett was the Chief Financial Officer of Medivation, Inc., a biopharmaceutical company, which was acquired by Pfizer Inc. Prior to that, Ms. Jarrett spent 20 years in investment banking, most recently as Managing Director at Citigroup from July 2010 to March 2016, where she was responsible for managing their west coast life sciences investment banking practice. Ms. Jarrett currently serves on the board of directors of Damora Therapeutics, Zura Bio Ltd (Nasdaq: ZURA), Syndax Pharmaceuticals, Inc. (Nasdaq: SNDX), and LifeMine Therapeutics, Inc. Ms. Jarrett previously served on the boards of directors of Arena Pharmaceuticals, Inc. from July 2017 until its acquisition by Pfizer in March 2022, Audentes Therapeutics from July 2017 until its acquisition by Astellas Pharma Inc. in January 2020, Radius Health, Inc. from May 2022 until its acquisition by Gurnet Point Capital and Patient Square Capital in August 2022, and Consonance-HFW Acquisition Corp. from December 2020 until its business combination with Surrozen Operating, Inc. in August 2021. Ms. Jarrett holds a B.A. in Economics, cum laude, from Dartmouth College and an M.B.A. from Stanford Graduate School of Business. | **Jennifer Jarrett** has served as a member of our Board since August 2024. Ms. Jarrett currently serves as the President, Chief Executive Officer and board director at Damora Therapeutics (Nasdaq: DMRA). From 2021 until March 2026, she served as Chief Operating Officer of Arcus Biosciences, Inc., or Arcus, a clinical-stage, global biopharmaceutical company, and previously served on the board of directors of Arcus from January 2019 until January 2024. Prior to joining Arcus as Chief Operating Officer, Ms. Jarrett served as Vice President, Corporate Development and Capital Markets at Uber, Inc., a technology company providing a platform for mobility, delivery and freight services, from January 2019 to 2021 and prior to that, served as Arcus' Chief Operating and Financial Officer from March 2017 to January 2019. From April 2016 to October 2016, Ms. Jarrett was the Chief Financial Officer of Medivation, Inc., a biopharmaceutical company, which was acquired by Pfizer Inc. Prior to that, Ms. Jarrett spent 20 years in investment banking, most recently as Managing Director at Citigroup from July 2010 to March 2016, where she was responsible for managing their west coast life sciences investment banking practice. Ms. Jarrett currently serves on the board of directors of Damora Therapeutics, Zura Bio Ltd (Nasdaq: ZURA), Syndax Pharmaceuticals, Inc. (Nasdaq: SNDX), and LifeMine Therapeutics, Inc. Ms. Jarrett previously served on the boards of directors of Arena Pharmaceuticals, Inc. from July 2017 until its acquisition by Pfizer in March 2022, Audentes Therapeutics from July 2017 until its acquisition by Astellas Pharma Inc. in January 2020, Radius Health, Inc. from May 2022 until its acquisition by Gurnet Point Capital and Patient Square Capital in August 2022, and Consonance-HFW Acquisition Corp. from December 2020 until its business combination with Surrozen Operating, Inc. in August 2021. Ms. Jarrett holds a B.A. in Economics, cum laude, from Dartmouth College and an M.B.A. from Stanford Graduate School of Business. |
| ***Skills & Qualifications:*** We believe that Ms. Jarrett is qualified to serve on our Board due to her significant financial, business and strategic experience in the life sciences sector.  | ***Skills & Qualifications:*** We believe that Ms. Jarrett is qualified to serve on our Board due to her significant financial, business and strategic experience in the life sciences sector.  | ***Skills & Qualifications:*** We believe that Ms. Jarrett is qualified to serve on our Board due to her significant financial, business and strategic experience in the life sciences sector.  |

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| **ANNE PHILLIPS, M.D.** | **ANNE PHILLIPS, M.D.** | **ANNE PHILLIPS, M.D.** |
| **Age: 72 <br> Director Since: 2024**  | **Committee Memberships**: Nominating and Corporate Governance, Compensation | **Other Public Directorships**: <br> Barinthus Biotherapeutics plc, vTv Therapeutics Inc. |
| **Anne Phillips, M.D.** has served as a member of our Board since August 2024. Dr. Phillips has over 25 years of pharmaceutical industry experience. Ms. Phillips joined our Board following a tenure at Novo Nordisk A/S, or Novo Nordisk, a global healthcare company, where she most recently served as a Senior Vice President of Clinical, Medical & Regulatory Affairs, North America Operations, leading the drug development, clinical operations, medical, regulatory, health economics and outcomes research, and safety teams, from January 2011 to August 2022. Prior to joining Novo Nordisk, Dr. Phillips held positions of increasing seniority at GSK plc from 1998 to 2004, most recently as Vice President and Head of R&D. Dr. Phillips currently serves on the board of directors of Barinthus Biotherapeutics plc (Nasdaq: BRNS), a clinical-stage biopharmaceutical company, a position she has held since February 2021, and most recently, vTv Therapeutics Inc. (Nasdaq: VTVT), a clinical-stage public biopharmaceutical company, whose board she joined in March 2024. Dr. Phillips previously served as a member of the board of directors of Trevena, Inc. (Nasdaq: TRVN), a biopharmaceutical company, from December 2014 to November 2024, Carmot Therapeutics Inc., a biopharmaceutical company, from September 2022 to December 2023, when it was acquired by F. Hoffmann-La Roche AG and AMAG Pharmaceuticals, Inc., a pharmaceutical company, from April 2019 to November 2020. Dr. Phillips received an Hon. B.Sc. in Zoology from the University of Western Ontario and an M.D. from the University of Toronto. She completed postgraduate training in Internal Medicine, Medical Microbiology and Infectious Diseases. | **Anne Phillips, M.D.** has served as a member of our Board since August 2024. Dr. Phillips has over 25 years of pharmaceutical industry experience. Ms. Phillips joined our Board following a tenure at Novo Nordisk A/S, or Novo Nordisk, a global healthcare company, where she most recently served as a Senior Vice President of Clinical, Medical & Regulatory Affairs, North America Operations, leading the drug development, clinical operations, medical, regulatory, health economics and outcomes research, and safety teams, from January 2011 to August 2022. Prior to joining Novo Nordisk, Dr. Phillips held positions of increasing seniority at GSK plc from 1998 to 2004, most recently as Vice President and Head of R&D. Dr. Phillips currently serves on the board of directors of Barinthus Biotherapeutics plc (Nasdaq: BRNS), a clinical-stage biopharmaceutical company, a position she has held since February 2021, and most recently, vTv Therapeutics Inc. (Nasdaq: VTVT), a clinical-stage public biopharmaceutical company, whose board she joined in March 2024. Dr. Phillips previously served as a member of the board of directors of Trevena, Inc. (Nasdaq: TRVN), a biopharmaceutical company, from December 2014 to November 2024, Carmot Therapeutics Inc., a biopharmaceutical company, from September 2022 to December 2023, when it was acquired by F. Hoffmann-La Roche AG and AMAG Pharmaceuticals, Inc., a pharmaceutical company, from April 2019 to November 2020. Dr. Phillips received an Hon. B.Sc. in Zoology from the University of Western Ontario and an M.D. from the University of Toronto. She completed postgraduate training in Internal Medicine, Medical Microbiology and Infectious Diseases. | **Anne Phillips, M.D.** has served as a member of our Board since August 2024. Dr. Phillips has over 25 years of pharmaceutical industry experience. Ms. Phillips joined our Board following a tenure at Novo Nordisk A/S, or Novo Nordisk, a global healthcare company, where she most recently served as a Senior Vice President of Clinical, Medical & Regulatory Affairs, North America Operations, leading the drug development, clinical operations, medical, regulatory, health economics and outcomes research, and safety teams, from January 2011 to August 2022. Prior to joining Novo Nordisk, Dr. Phillips held positions of increasing seniority at GSK plc from 1998 to 2004, most recently as Vice President and Head of R&D. Dr. Phillips currently serves on the board of directors of Barinthus Biotherapeutics plc (Nasdaq: BRNS), a clinical-stage biopharmaceutical company, a position she has held since February 2021, and most recently, vTv Therapeutics Inc. (Nasdaq: VTVT), a clinical-stage public biopharmaceutical company, whose board she joined in March 2024. Dr. Phillips previously served as a member of the board of directors of Trevena, Inc. (Nasdaq: TRVN), a biopharmaceutical company, from December 2014 to November 2024, Carmot Therapeutics Inc., a biopharmaceutical company, from September 2022 to December 2023, when it was acquired by F. Hoffmann-La Roche AG and AMAG Pharmaceuticals, Inc., a pharmaceutical company, from April 2019 to November 2020. Dr. Phillips received an Hon. B.Sc. in Zoology from the University of Western Ontario and an M.D. from the University of Toronto. She completed postgraduate training in Internal Medicine, Medical Microbiology and Infectious Diseases. |
| ***Skills & Qualifications:*** We believe that Dr. Phillips is qualified to serve on our Board due to her significant pharmaceutical industry experience. | ***Skills & Qualifications:*** We believe that Dr. Phillips is qualified to serve on our Board due to her significant pharmaceutical industry experience. | ***Skills & Qualifications:*** We believe that Dr. Phillips is qualified to serve on our Board due to her significant pharmaceutical industry experience. |

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| **DAVID HAPPEL** | **DAVID HAPPEL** | **DAVID HAPPEL** |
| **Age: 64 <br> Director Since: 2022**  | **Committee Memberships: None**  | **Other Public Directorships**: None |
| **David Happel** has served as our Chief Executive Officer and a director since October 2022. From March 2020 through October 2022, he was President and Chief Executive Officer, and a director on the board of Cognoa, Inc., a pediatric behavioral health company developing AI-based technologies for developmental and behavioral health conditions, including the first FDA-authorized diagnostic aid, Canvas Dx, for autism. From February 2018 to March 2020, Mr. Happel was President, Chief Executive Officer and a director on the board of Chrono Therapeutics Inc. In addition, Mr. Happel has served as a director of Currax Pharmaceuticals LLC since 2020 and he previously held several executive and commercial positions at Horizon Therapeutics plc, or Horizon, Raptor Pharmaceutical Corp., Dynavax Technologies Corporation and Chiron Corporation. Mr. Happel also currently sits on the board of a privately held company. Mr. Happel has a B.A. in chemistry from Indiana University and an M.B.A. from Indiana State University. | **David Happel** has served as our Chief Executive Officer and a director since October 2022. From March 2020 through October 2022, he was President and Chief Executive Officer, and a director on the board of Cognoa, Inc., a pediatric behavioral health company developing AI-based technologies for developmental and behavioral health conditions, including the first FDA-authorized diagnostic aid, Canvas Dx, for autism. From February 2018 to March 2020, Mr. Happel was President, Chief Executive Officer and a director on the board of Chrono Therapeutics Inc. In addition, Mr. Happel has served as a director of Currax Pharmaceuticals LLC since 2020 and he previously held several executive and commercial positions at Horizon Therapeutics plc, or Horizon, Raptor Pharmaceutical Corp., Dynavax Technologies Corporation and Chiron Corporation. Mr. Happel also currently sits on the board of a privately held company. Mr. Happel has a B.A. in chemistry from Indiana University and an M.B.A. from Indiana State University. | **David Happel** has served as our Chief Executive Officer and a director since October 2022. From March 2020 through October 2022, he was President and Chief Executive Officer, and a director on the board of Cognoa, Inc., a pediatric behavioral health company developing AI-based technologies for developmental and behavioral health conditions, including the first FDA-authorized diagnostic aid, Canvas Dx, for autism. From February 2018 to March 2020, Mr. Happel was President, Chief Executive Officer and a director on the board of Chrono Therapeutics Inc. In addition, Mr. Happel has served as a director of Currax Pharmaceuticals LLC since 2020 and he previously held several executive and commercial positions at Horizon Therapeutics plc, or Horizon, Raptor Pharmaceutical Corp., Dynavax Technologies Corporation and Chiron Corporation. Mr. Happel also currently sits on the board of a privately held company. Mr. Happel has a B.A. in chemistry from Indiana University and an M.B.A. from Indiana State University. |
| ***Skills & Qualifications:*** We believe that Mr. Happel is qualified to serve on our Board due to the valuable experience he brings in his capacity as our President and Chief Executive Officer along with significant leadership experience in the life science industry. | ***Skills & Qualifications:*** We believe that Mr. Happel is qualified to serve on our Board due to the valuable experience he brings in his capacity as our President and Chief Executive Officer along with significant leadership experience in the life science industry. | ***Skills & Qualifications:*** We believe that Mr. Happel is qualified to serve on our Board due to the valuable experience he brings in his capacity as our President and Chief Executive Officer along with significant leadership experience in the life science industry. |

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| **GEORGE KEMBLE, PH.D.** | **GEORGE KEMBLE, PH.D.** | **GEORGE KEMBLE, PH.D.** |
| **Age: 65 <br> Director Since: 2015**  | **Committee Memberships: None**  | **Other Public Directorships**: None |
| **George Kemble, Ph.D.** has served as a director since October 2015 and as Chairman of the Board since May 2025. From October 2022 until May 2025 he served as our Executive Chairman of the Board. He previously served as our Chief Executive Officer from October 2015 through October 2022, in addition to serving as our Chief Scientific Officer from August 2011 through October 2022. From 2001 through 2011, he held various leadership positions at MedImmune LLC, a biologics company and subsidiary of AstraZeneca PLC, including Vice President of Research & Development for Vaccines, Senior Vice President of Research for Biologics and General Manager of the California operations. Early in his career, from 1993 until 2001, he was a research scientist at Aviron Ltd. focusing on viral vaccine technologies. He received his B.S. in biology from Santa Clara University, a Ph.D. from Stanford University from the department of microbiology and immunology and held a postdoctoral research fellowship at University of California, San Francisco. | **George Kemble, Ph.D.** has served as a director since October 2015 and as Chairman of the Board since May 2025. From October 2022 until May 2025 he served as our Executive Chairman of the Board. He previously served as our Chief Executive Officer from October 2015 through October 2022, in addition to serving as our Chief Scientific Officer from August 2011 through October 2022. From 2001 through 2011, he held various leadership positions at MedImmune LLC, a biologics company and subsidiary of AstraZeneca PLC, including Vice President of Research & Development for Vaccines, Senior Vice President of Research for Biologics and General Manager of the California operations. Early in his career, from 1993 until 2001, he was a research scientist at Aviron Ltd. focusing on viral vaccine technologies. He received his B.S. in biology from Santa Clara University, a Ph.D. from Stanford University from the department of microbiology and immunology and held a postdoctoral research fellowship at University of California, San Francisco. | **George Kemble, Ph.D.** has served as a director since October 2015 and as Chairman of the Board since May 2025. From October 2022 until May 2025 he served as our Executive Chairman of the Board. He previously served as our Chief Executive Officer from October 2015 through October 2022, in addition to serving as our Chief Scientific Officer from August 2011 through October 2022. From 2001 through 2011, he held various leadership positions at MedImmune LLC, a biologics company and subsidiary of AstraZeneca PLC, including Vice President of Research & Development for Vaccines, Senior Vice President of Research for Biologics and General Manager of the California operations. Early in his career, from 1993 until 2001, he was a research scientist at Aviron Ltd. focusing on viral vaccine technologies. He received his B.S. in biology from Santa Clara University, a Ph.D. from Stanford University from the department of microbiology and immunology and held a postdoctoral research fellowship at University of California, San Francisco. |
| ***Skills & Qualifications:*** We believe that Dr. Kemble is qualified to serve on our Board due to his experience with scientific programs spanning stages from early research through licensure, combined with his leadership of organizations integrating both scientific and business disciplines. | ***Skills & Qualifications:*** We believe that Dr. Kemble is qualified to serve on our Board due to his experience with scientific programs spanning stages from early research through licensure, combined with his leadership of organizations integrating both scientific and business disciplines. | ***Skills & Qualifications:*** We believe that Dr. Kemble is qualified to serve on our Board due to his experience with scientific programs spanning stages from early research through licensure, combined with his leadership of organizations integrating both scientific and business disciplines. |

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#### CONTINUING DIRECTORS

#### CLASS I DIRECTORS — TERMS EXPIRING AT THE 2027 ANNUAL MEETING OF STOCKHOLDERS

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| **TIMOTHY P. WALBERT** | **TIMOTHY P. WALBERT** | **TIMOTHY P. WALBERT** |
| **Age: 59 <br> Director Since: 2024**  | **Committee Memberships**: <br> Audit, Compensation | **Other Public Directorships**: Century Therapeutics, Inc., Mirum Pharmaceuticals, Inc., BioMarin Pharmaceuticals |
| **Timothy P. Walbert** has served as a member of our Board since April 2024. Mr. Walbert has served as a senior advisor to Amgen Inc., or Amgen, since October 2023. Mr. Walbert was Chairman, President and Chief Executive Officer of Horizon, a public biotech company, from June 2008 to October 2023, when it was acquired by Amgen for $28 billion. Before joining Horizon, he was President, Chief Executive Officer and a director of IDM Pharma Inc., or IDM, a public biotechnology company, which was acquired by Takeda in June 2009. Before IDM, Mr. Walbert served as Executive Vice President, Commercial Operations at NeoPharm Inc., a public biotechnology company. From 2001 to 2005, he was Divisional Vice President and General Manager, Immunology, at Abbott Laboratories, now AbbVie Inc., leading the global development and launch of the multi-indication biologic HUMIRA, and served as divisional vice president, global cardiovascular strategy. From 1998 to 2001, Mr. Walbert served as Director, CELEBREX North America, and Arthritis Team Leader, Asia Pacific, Latin America and Canada, at G.D. Searle & Company. From 1991 to 1998, he also held sales and marketing roles with increasing responsibility at G.D. Searle, Merck & Co., Inc. and Wyeth. He currently serves on the boards of Mirum Pharmaceuticals, Inc. (Nasdaq: MIRM), BioMarin Pharmaceutical, Inc. (Nasdaq: BMRN) and Century Therapeutics, Inc. (Nasdaq: IPSC), each a public biotech company, where he has been a director since April 2023, February 2025, and October 2022, respectively. He also serves on the board of Crystalys Therapeutics, Inc., Odyssey Therapeutics, Inc., Cour Pharmaceuticals Development Company, Inc., Catalent, Inc., and is chairman of the board of directors of Latigo Biotherapeutics, Inc., each private biotech companies. He previously served as chairman of the board of directors of Horizon (acquired by Amgen) from June 2008 to October 2023. He previously served on the board of directors for Aurinia Pharmaceuticals Inc. (Nasdaq: AUPH), a public pharmaceutical company, from 2020 to 2022; Exicure, Inc. (Nasdaq: XCUR), a public biotechnology company, from 2019 to 2022; Assertio Therapeutics, Inc. (Nasdaq: ASRT), a public biopharma company, from 2014 to 2020; Raptor Pharmaceutical Corp. (Nasdaq: RPTP), a public biotechnology company, from 2010 to 2014; XOMA Corporation (Nasdaq: XOMA), a public biotechnology company, from 2011 to 2017; Sucampo Pharmaceuticals Inc. a formerly-public biopharmaceutical company (now part of Mallinckrodt plc), from 2016 to 2018; and served as chairman of the board of directors of Horizon (acquired by Amgen) from June 2008 to October 2023. He is also a member of the Economic Club of Chicago, the Commercial Club of Chicago. Mr. Walbert previously served on the boards of the Biotechnology Innovation Organization, the Pharmaceutical Research and Manufacturing Association, the Illinois Biotechnology Innovation Organization and World Business Chicago. Mr. Walbert received a Bachelor of Arts in business from Muhlenberg College in Allentown, PA. | **Timothy P. Walbert** has served as a member of our Board since April 2024. Mr. Walbert has served as a senior advisor to Amgen Inc., or Amgen, since October 2023. Mr. Walbert was Chairman, President and Chief Executive Officer of Horizon, a public biotech company, from June 2008 to October 2023, when it was acquired by Amgen for $28 billion. Before joining Horizon, he was President, Chief Executive Officer and a director of IDM Pharma Inc., or IDM, a public biotechnology company, which was acquired by Takeda in June 2009. Before IDM, Mr. Walbert served as Executive Vice President, Commercial Operations at NeoPharm Inc., a public biotechnology company. From 2001 to 2005, he was Divisional Vice President and General Manager, Immunology, at Abbott Laboratories, now AbbVie Inc., leading the global development and launch of the multi-indication biologic HUMIRA, and served as divisional vice president, global cardiovascular strategy. From 1998 to 2001, Mr. Walbert served as Director, CELEBREX North America, and Arthritis Team Leader, Asia Pacific, Latin America and Canada, at G.D. Searle & Company. From 1991 to 1998, he also held sales and marketing roles with increasing responsibility at G.D. Searle, Merck & Co., Inc. and Wyeth. He currently serves on the boards of Mirum Pharmaceuticals, Inc. (Nasdaq: MIRM), BioMarin Pharmaceutical, Inc. (Nasdaq: BMRN) and Century Therapeutics, Inc. (Nasdaq: IPSC), each a public biotech company, where he has been a director since April 2023, February 2025, and October 2022, respectively. He also serves on the board of Crystalys Therapeutics, Inc., Odyssey Therapeutics, Inc., Cour Pharmaceuticals Development Company, Inc., Catalent, Inc., and is chairman of the board of directors of Latigo Biotherapeutics, Inc., each private biotech companies. He previously served as chairman of the board of directors of Horizon (acquired by Amgen) from June 2008 to October 2023. He previously served on the board of directors for Aurinia Pharmaceuticals Inc. (Nasdaq: AUPH), a public pharmaceutical company, from 2020 to 2022; Exicure, Inc. (Nasdaq: XCUR), a public biotechnology company, from 2019 to 2022; Assertio Therapeutics, Inc. (Nasdaq: ASRT), a public biopharma company, from 2014 to 2020; Raptor Pharmaceutical Corp. (Nasdaq: RPTP), a public biotechnology company, from 2010 to 2014; XOMA Corporation (Nasdaq: XOMA), a public biotechnology company, from 2011 to 2017; Sucampo Pharmaceuticals Inc. a formerly-public biopharmaceutical company (now part of Mallinckrodt plc), from 2016 to 2018; and served as chairman of the board of directors of Horizon (acquired by Amgen) from June 2008 to October 2023. He is also a member of the Economic Club of Chicago, the Commercial Club of Chicago. Mr. Walbert previously served on the boards of the Biotechnology Innovation Organization, the Pharmaceutical Research and Manufacturing Association, the Illinois Biotechnology Innovation Organization and World Business Chicago. Mr. Walbert received a Bachelor of Arts in business from Muhlenberg College in Allentown, PA. | **Timothy P. Walbert** has served as a member of our Board since April 2024. Mr. Walbert has served as a senior advisor to Amgen Inc., or Amgen, since October 2023. Mr. Walbert was Chairman, President and Chief Executive Officer of Horizon, a public biotech company, from June 2008 to October 2023, when it was acquired by Amgen for $28 billion. Before joining Horizon, he was President, Chief Executive Officer and a director of IDM Pharma Inc., or IDM, a public biotechnology company, which was acquired by Takeda in June 2009. Before IDM, Mr. Walbert served as Executive Vice President, Commercial Operations at NeoPharm Inc., a public biotechnology company. From 2001 to 2005, he was Divisional Vice President and General Manager, Immunology, at Abbott Laboratories, now AbbVie Inc., leading the global development and launch of the multi-indication biologic HUMIRA, and served as divisional vice president, global cardiovascular strategy. From 1998 to 2001, Mr. Walbert served as Director, CELEBREX North America, and Arthritis Team Leader, Asia Pacific, Latin America and Canada, at G.D. Searle & Company. From 1991 to 1998, he also held sales and marketing roles with increasing responsibility at G.D. Searle, Merck & Co., Inc. and Wyeth. He currently serves on the boards of Mirum Pharmaceuticals, Inc. (Nasdaq: MIRM), BioMarin Pharmaceutical, Inc. (Nasdaq: BMRN) and Century Therapeutics, Inc. (Nasdaq: IPSC), each a public biotech company, where he has been a director since April 2023, February 2025, and October 2022, respectively. He also serves on the board of Crystalys Therapeutics, Inc., Odyssey Therapeutics, Inc., Cour Pharmaceuticals Development Company, Inc., Catalent, Inc., and is chairman of the board of directors of Latigo Biotherapeutics, Inc., each private biotech companies. He previously served as chairman of the board of directors of Horizon (acquired by Amgen) from June 2008 to October 2023. He previously served on the board of directors for Aurinia Pharmaceuticals Inc. (Nasdaq: AUPH), a public pharmaceutical company, from 2020 to 2022; Exicure, Inc. (Nasdaq: XCUR), a public biotechnology company, from 2019 to 2022; Assertio Therapeutics, Inc. (Nasdaq: ASRT), a public biopharma company, from 2014 to 2020; Raptor Pharmaceutical Corp. (Nasdaq: RPTP), a public biotechnology company, from 2010 to 2014; XOMA Corporation (Nasdaq: XOMA), a public biotechnology company, from 2011 to 2017; Sucampo Pharmaceuticals Inc. a formerly-public biopharmaceutical company (now part of Mallinckrodt plc), from 2016 to 2018; and served as chairman of the board of directors of Horizon (acquired by Amgen) from June 2008 to October 2023. He is also a member of the Economic Club of Chicago, the Commercial Club of Chicago. Mr. Walbert previously served on the boards of the Biotechnology Innovation Organization, the Pharmaceutical Research and Manufacturing Association, the Illinois Biotechnology Innovation Organization and World Business Chicago. Mr. Walbert received a Bachelor of Arts in business from Muhlenberg College in Allentown, PA. |
| ***Skills & Qualifications:*** We believe that Mr. Walbert is qualified to serve on our Board due to his extensive executive-level leadership experience in the biotechnology industry. | ***Skills & Qualifications:*** We believe that Mr. Walbert is qualified to serve on our Board due to his extensive executive-level leadership experience in the biotechnology industry. | ***Skills & Qualifications:*** We believe that Mr. Walbert is qualified to serve on our Board due to his extensive executive-level leadership experience in the biotechnology industry. |

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| **PAUL HOELSCHER** | **PAUL HOELSCHER** | **PAUL HOELSCHER** |
| **Age: 61 <br> Director Since: 2024**  | **Committee Memberships**: Audit (Chair) | **Other Public Directorships**: None |
| **Paul Hoelscher** has served as a member of our Board since April 2024. Mr. Hoelscher served as Executive Vice President and Chief Financial Officer of Horizon, from 2014 until his retirement in May 2022, overseeing all aspects of Horizon's financial operations. Prior to joining Horizon, Mr. Hoelscher held financial executive positions at OfficeMax, Inc., or OfficeMax, a business services company, from 2012 to 2014, including serving as Senior Vice President, Finance, Treasury and Corporate Development and co-leading the integration of OfficeMax and Office Depot Inc. Previously, Mr. Hoelscher held various financial leadership roles of increasing responsibility over nineteen years at Alberto Culver Company, a beauty care company, and worked in the audit practice of KPMG for seven years. Mr. Hoelscher received his B.S. in accountancy from the University of Illinois at Urbana-Champaign and is a certified public accountant. Mr. Hoelscher served on the board of Reneo Pharmaceuticals, Inc. (now OnKure Therapeutics, Inc. (Nasdaq: OKUR)), a public pharmaceutical company, from January 2022 to October 2024, and served on the board of trustees of the Illinois Region of The Leukemia & Lymphoma Society from 2007 to 2022, including two terms as board chair. | **Paul Hoelscher** has served as a member of our Board since April 2024. Mr. Hoelscher served as Executive Vice President and Chief Financial Officer of Horizon, from 2014 until his retirement in May 2022, overseeing all aspects of Horizon's financial operations. Prior to joining Horizon, Mr. Hoelscher held financial executive positions at OfficeMax, Inc., or OfficeMax, a business services company, from 2012 to 2014, including serving as Senior Vice President, Finance, Treasury and Corporate Development and co-leading the integration of OfficeMax and Office Depot Inc. Previously, Mr. Hoelscher held various financial leadership roles of increasing responsibility over nineteen years at Alberto Culver Company, a beauty care company, and worked in the audit practice of KPMG for seven years. Mr. Hoelscher received his B.S. in accountancy from the University of Illinois at Urbana-Champaign and is a certified public accountant. Mr. Hoelscher served on the board of Reneo Pharmaceuticals, Inc. (now OnKure Therapeutics, Inc. (Nasdaq: OKUR)), a public pharmaceutical company, from January 2022 to October 2024, and served on the board of trustees of the Illinois Region of The Leukemia & Lymphoma Society from 2007 to 2022, including two terms as board chair. | **Paul Hoelscher** has served as a member of our Board since April 2024. Mr. Hoelscher served as Executive Vice President and Chief Financial Officer of Horizon, from 2014 until his retirement in May 2022, overseeing all aspects of Horizon's financial operations. Prior to joining Horizon, Mr. Hoelscher held financial executive positions at OfficeMax, Inc., or OfficeMax, a business services company, from 2012 to 2014, including serving as Senior Vice President, Finance, Treasury and Corporate Development and co-leading the integration of OfficeMax and Office Depot Inc. Previously, Mr. Hoelscher held various financial leadership roles of increasing responsibility over nineteen years at Alberto Culver Company, a beauty care company, and worked in the audit practice of KPMG for seven years. Mr. Hoelscher received his B.S. in accountancy from the University of Illinois at Urbana-Champaign and is a certified public accountant. Mr. Hoelscher served on the board of Reneo Pharmaceuticals, Inc. (now OnKure Therapeutics, Inc. (Nasdaq: OKUR)), a public pharmaceutical company, from January 2022 to October 2024, and served on the board of trustees of the Illinois Region of The Leukemia & Lymphoma Society from 2007 to 2022, including two terms as board chair. |
| ***Skills & Qualifications:*** We believe that Mr. Hoelscher is qualified to serve on our Board due to his extensive public company experience in financial leadership roles.  | ***Skills & Qualifications:*** We believe that Mr. Hoelscher is qualified to serve on our Board due to his extensive public company experience in financial leadership roles.  | ***Skills & Qualifications:*** We believe that Mr. Hoelscher is qualified to serve on our Board due to his extensive public company experience in financial leadership roles.  |

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#### CLASS II DIRECTORS — TERMS EXPIRING AT THE 2028 ANNUAL MEETING OF STOCKHOLDERS

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| **ELIZABETH GRAMMER, ESQ.** | **ELIZABETH GRAMMER, ESQ.** | **ELIZABETH GRAMMER, ESQ.** |
| **Age: 62 <br> Director Since: 2021**  | **Committee Memberships**: Nominating and Corporate Governance (Chair) | **Other Public Directorships**: None |
| **Elizabeth Grammer, Esq.** has served as a member of our Board since April 2021. Currently, Ms. Grammer serves as a Senior Advisor of Ardelyx, Inc., or Ardelyx. From January 2020 to December 2025, she served as the Chief Legal and Administrative Officer of Ardelyx. From May 2014 to January 2020, she served as the General Counsel of Ardelyx and from December 2012 until May 2014, she served as the Vice President of Legal Affairs. From 2006 to December 2012, Ms. Grammer served as an independent outside corporate counsel for public and private biotechnology companies. From 2001 to 2006, Ms. Grammer served as Vice President and General Counsel of Trine Pharmaceuticals, Inc., a biopharmaceutical company. In addition, Ms. Grammer previously served as independent outside corporate counsel to GelTex Pharmaceuticals Inc, a biopharmaceutical company. Ms. Grammer also previously served on the board of directors of the California Life Sciences Association from 2018 to 2021. Ms. Grammer received a B.A. in political science from Boston University and a J.D. from Stanford Law School. | **Elizabeth Grammer, Esq.** has served as a member of our Board since April 2021. Currently, Ms. Grammer serves as a Senior Advisor of Ardelyx, Inc., or Ardelyx. From January 2020 to December 2025, she served as the Chief Legal and Administrative Officer of Ardelyx. From May 2014 to January 2020, she served as the General Counsel of Ardelyx and from December 2012 until May 2014, she served as the Vice President of Legal Affairs. From 2006 to December 2012, Ms. Grammer served as an independent outside corporate counsel for public and private biotechnology companies. From 2001 to 2006, Ms. Grammer served as Vice President and General Counsel of Trine Pharmaceuticals, Inc., a biopharmaceutical company. In addition, Ms. Grammer previously served as independent outside corporate counsel to GelTex Pharmaceuticals Inc, a biopharmaceutical company. Ms. Grammer also previously served on the board of directors of the California Life Sciences Association from 2018 to 2021. Ms. Grammer received a B.A. in political science from Boston University and a J.D. from Stanford Law School. | **Elizabeth Grammer, Esq.** has served as a member of our Board since April 2021. Currently, Ms. Grammer serves as a Senior Advisor of Ardelyx, Inc., or Ardelyx. From January 2020 to December 2025, she served as the Chief Legal and Administrative Officer of Ardelyx. From May 2014 to January 2020, she served as the General Counsel of Ardelyx and from December 2012 until May 2014, she served as the Vice President of Legal Affairs. From 2006 to December 2012, Ms. Grammer served as an independent outside corporate counsel for public and private biotechnology companies. From 2001 to 2006, Ms. Grammer served as Vice President and General Counsel of Trine Pharmaceuticals, Inc., a biopharmaceutical company. In addition, Ms. Grammer previously served as independent outside corporate counsel to GelTex Pharmaceuticals Inc, a biopharmaceutical company. Ms. Grammer also previously served on the board of directors of the California Life Sciences Association from 2018 to 2021. Ms. Grammer received a B.A. in political science from Boston University and a J.D. from Stanford Law School. |
| ***Skills & Qualifications:*** We believe that Ms. Grammer is qualified to serve on our Board due to her extensive experience in the biopharma and pharmaceutical sector and in law. | ***Skills & Qualifications:*** We believe that Ms. Grammer is qualified to serve on our Board due to her extensive experience in the biopharma and pharmaceutical sector and in law. | ***Skills & Qualifications:*** We believe that Ms. Grammer is qualified to serve on our Board due to her extensive experience in the biopharma and pharmaceutical sector and in law. |

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| **BETH SEIDENBERG, M.D.** | **BETH SEIDENBERG, M.D.** | **BETH SEIDENBERG, M.D.** |
| **Age: 69 <br> Director Since: 2007**  | **Committee Memberships**: Compensation (Chair) | **Other Public Directorships**: <br> Vera Therapeutics, Inc., Kyverna Therapeutics, Inc. |
| **Beth Seidenberg, M.D.** has served as a member of our Board since April 2007 and was appointed our Board's Lead Independent Director in May 2025. Dr. Seidenberg serves as a Managing Director of Westlake BioPartners, a life sciences venture capital firm she founded in September 2018. Since May 2005, Dr. Seidenberg has served as a general partner at Kleiner Perkins Caufield & Byers, LLC, where she has primarily focused on life science investing. Dr. Seidenberg was previously the Senior Vice President, Head of Global Development and Chief Medical Officer at Amgen Inc. Previously, Dr. Seidenberg was a senior executive in research and development at Bristol Myers Squibb Company and Merck & Co., Inc. Dr. Seidenberg received a B.A. in biology and anthropology from Barnard College and an M.D. from the University of Miami School of Medicine and completed her post-graduate training at Johns Hopkins University, George Washington University and the National Institutes of Health. Dr. Seidenberg currently serves on the boards of directors of Vera Therapeutics, Inc. (Nasdaq: VERA) and Kyverna Therapeutics, Inc. (Nasdaq: KYTX); positions she has held since June 2016 and September 2018, respectively. Dr. Seidenberg also serves on the board of directors of several privately held life sciences companies. She previously served on the board of directors of Acelyrin, Inc. (acquired by Alumis; (Nasdaq: SLRN)) from October 2020 until May 2025, Progyny, Inc. from May 2010 until November 2025, and Atara Biotherapeutics, Inc. (Nasdaq: ATRA) from August 2012 until June 2023. | **Beth Seidenberg, M.D.** has served as a member of our Board since April 2007 and was appointed our Board's Lead Independent Director in May 2025. Dr. Seidenberg serves as a Managing Director of Westlake BioPartners, a life sciences venture capital firm she founded in September 2018. Since May 2005, Dr. Seidenberg has served as a general partner at Kleiner Perkins Caufield & Byers, LLC, where she has primarily focused on life science investing. Dr. Seidenberg was previously the Senior Vice President, Head of Global Development and Chief Medical Officer at Amgen Inc. Previously, Dr. Seidenberg was a senior executive in research and development at Bristol Myers Squibb Company and Merck & Co., Inc. Dr. Seidenberg received a B.A. in biology and anthropology from Barnard College and an M.D. from the University of Miami School of Medicine and completed her post-graduate training at Johns Hopkins University, George Washington University and the National Institutes of Health. Dr. Seidenberg currently serves on the boards of directors of Vera Therapeutics, Inc. (Nasdaq: VERA) and Kyverna Therapeutics, Inc. (Nasdaq: KYTX); positions she has held since June 2016 and September 2018, respectively. Dr. Seidenberg also serves on the board of directors of several privately held life sciences companies. She previously served on the board of directors of Acelyrin, Inc. (acquired by Alumis; (Nasdaq: SLRN)) from October 2020 until May 2025, Progyny, Inc. from May 2010 until November 2025, and Atara Biotherapeutics, Inc. (Nasdaq: ATRA) from August 2012 until June 2023. | **Beth Seidenberg, M.D.** has served as a member of our Board since April 2007 and was appointed our Board's Lead Independent Director in May 2025. Dr. Seidenberg serves as a Managing Director of Westlake BioPartners, a life sciences venture capital firm she founded in September 2018. Since May 2005, Dr. Seidenberg has served as a general partner at Kleiner Perkins Caufield & Byers, LLC, where she has primarily focused on life science investing. Dr. Seidenberg was previously the Senior Vice President, Head of Global Development and Chief Medical Officer at Amgen Inc. Previously, Dr. Seidenberg was a senior executive in research and development at Bristol Myers Squibb Company and Merck & Co., Inc. Dr. Seidenberg received a B.A. in biology and anthropology from Barnard College and an M.D. from the University of Miami School of Medicine and completed her post-graduate training at Johns Hopkins University, George Washington University and the National Institutes of Health. Dr. Seidenberg currently serves on the boards of directors of Vera Therapeutics, Inc. (Nasdaq: VERA) and Kyverna Therapeutics, Inc. (Nasdaq: KYTX); positions she has held since June 2016 and September 2018, respectively. Dr. Seidenberg also serves on the board of directors of several privately held life sciences companies. She previously served on the board of directors of Acelyrin, Inc. (acquired by Alumis; (Nasdaq: SLRN)) from October 2020 until May 2025, Progyny, Inc. from May 2010 until November 2025, and Atara Biotherapeutics, Inc. (Nasdaq: ATRA) from August 2012 until June 2023. |
| ***Skills & Qualifications:*** We believe that Dr. Seidenberg is qualified to serve on our Board due to her training as a physician and her experience in the life sciences industry as a senior executive and venture capitalist who has incubated and invested in twenty-five biotechnology ventures. | ***Skills & Qualifications:*** We believe that Dr. Seidenberg is qualified to serve on our Board due to her training as a physician and her experience in the life sciences industry as a senior executive and venture capitalist who has incubated and invested in twenty-five biotechnology ventures. | ***Skills & Qualifications:*** We believe that Dr. Seidenberg is qualified to serve on our Board due to her training as a physician and her experience in the life sciences industry as a senior executive and venture capitalist who has incubated and invested in twenty-five biotechnology ventures. |

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#### CORPORATE GOVERNANCE AND RISK MANAGEMENT
We are committed to good corporate governance and integrity in our business dealings. We believe that strong corporate governance practices that provide meaningful rights to our stockholders and ensure Board and management accountability are key to our relationship with our stockholders. We strive to have regular, constructive conversations with our stockholders to better understand our stockholders' priorities and perspectives.

Our governance practices are documented in our Charter, our Bylaws, our Code of Conduct, our corporate governance guidelines, or the Corporate Governance Guidelines, and the charters of the committees of the Board, each of which is posted on our website at https://ir.sagimet.com/corporate-governance/governance-overview. Aspects of our governance documents are summarized below.

#### BOARD INDEPENDENCE
Under the listing standards, requirements and rules of Nasdaq, or the Nasdaq Listing Rules, independent directors must comprise a majority of our Board as a listed company within one year of the listing date. Our Board is currently comprised of a majority of independent directors.

Our Board has undertaken a review of the independence of each director. Based on information provided by each director concerning her or his background, employment and affiliations, including family relationships, our Board has determined that Dr. Seidenberg, Ms. Grammer, Mr. Hoelscher**,** Ms. Jarrett, Dr. Phillips, and Mr. Walbert do not have relationships that would interfere with the exercise of independent judgment in carrying out the responsibilities of a director and that each of these directors is "independent" as that term is defined under the Nasdaq Listing Rules. Our Board has determined that each of Mr. Happel, by virtue of his position as our current Chief Executive Officer, and Dr. Kemble, by virtue of his prior position as our former Chief Executive Officer, are not independent under applicable rules and regulations of the SEC and the Nasdaq Listing Rules. In making these determinations, our Board considered the current and prior relationships that each non-employee director has with our Company and all other facts and circumstances our Board deemed relevant in determining their independence, including the beneficial ownership of our shares by each non-employee director and the transactions described in "Certain Relationships and Related Person Transactions."

#### BOARD LEADERSHIP STRUCTURE AND THE BOARD'S ROLE IN RISK OVERSIGHT
Dr. Kemble is the current Chairman of our Board and Mr. Happel is our current Chief Executive Officer, hence the roles of Chairman and Chief Executive Officer are separated. We believe that separating these positions allows our Chief Executive Officer to focus on our day-to-day business, while allowing the Chairman to lead the Board in its fundamental role of providing advice to and independent oversight of management. Our Board recognizes the time, effort and energy that the Chief Executive Officer is required to devote to his position in the current business environment, as well as the commitment required to serve as our Chairman. While our Bylaws and Corporate Governance Guidelines do not require that our Chairman and Chief Executive Officer positions be separate, our Board believes that having separate positions is the appropriate leadership structure for us at this time and demonstrates our commitment to good corporate governance.

Dr. Seidenberg, M.D. was appointed Lead Independent Director of our Board in May 2025. Our Board believes that the role of Lead Independent Director reinforces the Board's independence from management and creates an environment that encourages objective oversight of management's performance. The responsibilities of the Lead Independent Director include presiding at executive sessions of independent directors and serving as a liaison between our Chief Executive Officer, Chairman of the Board and our independent directors. The board periodically reviews its leadership structure to ensure that the chosen structure continues to strike the appropriate balance for the company and our stakeholders and enables us to promote the long-term interests of our shareholders.

Risk is inherent with every business, and how well a business manages risk can ultimately determine its success. Management is responsible for the day-to-day management of risks we face, while our Board, as a whole and through its committees, has responsibility for the oversight of risk management. In its risk oversight

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role, our Board has the responsibility to satisfy itself that the risk management processes designed and implemented by management are adequate and functioning as designed.

The role of our Board in overseeing the management of our risks is conducted primarily through committees of the Board, as disclosed in the descriptions of each of the committees below and in the charters of each of the committees. The full Board, or the appropriate Board committee in the case of risks that are under the purview of a particular committee, discusses with management our major risk exposures, their potential impact on us, and the steps we take to manage them. When a Board committee is responsible for evaluating and overseeing the management of a particular risk and such risk is discussed at a Board committee meeting, the chairperson of the relevant committee reports on the discussion to the full Board during the committee report portion of the next Board meeting. This enables the Board and its committees to coordinate in risk oversight, particularly with respect to risk interrelationships.

#### BOARD COMMITTEES
Our Board has established an audit committee, or the Audit Committee, a compensation committee, or the Compensation Committee, and the Nominating and Corporate Governance Committee. The composition and responsibilities of each of the committees of our Board are described below. Members serve on these committees until their resignation or until otherwise determined by our Board. Each committee has adopted a written charter that satisfies the application rules and regulation of the SEC and the Nasdaq Listing Rules, which we have posted to our website at www.sagimet.com. Our Board may establish other committees as it deems necessary or appropriate from time to time.

#### EVALUATING BOARD EFFECTIVENESS
The Board, led by the Nominating and Corporate Governance Committee, is committed to continuous improvement and believes annual self-evaluations are an important tool for evaluating effectiveness. Beginning in 2024, our Board began conducting an annual self-evaluation of the Board, which is presented by the Chairperson of the Nominating and Corporate Governance Committee to the Board for discussion. In addition, each committee conducts an annual self-assessment in a review process similar to that used by the Board.

#### CODE OF BUSINESS CONDUCT AND ETHICS
We have adopted a written Code of Conduct that applies to all our employees, officers and directors. This includes our principal executive officer, principal financial officer and our controller, or persons performing similar functions. The full text of our Code of Conduct is posted on our website at https://ir.sagimet.com/corporate-governance/governance-overview. We intend to disclose on our website any amendments of our Code of Conduct or waivers that exempt any principal executive officer, principal financial officer, principal accounting officer or controller, or persons performing similar functions or our directors from provisions in the Code of Conduct.

#### DIRECTOR ORIENTATION AND CONTINUING EDUCATION
We familiarize new directors with the Company's businesses, financial position, strategies, and policies, and assist them in developing the skills and knowledge required for their service on the Board. From time to time, management advises, or invites outside experts to attend Board meetings to advise, the Board on its responsibilities, management's responsibilities, developments relevant to corporate governance and best corporate practices. Additionally, Board members may attend, and are encouraged to attend, accredited director education programs at our expense.

#### CORPORATE GOVERNANCE GUIDELINES
We have a written set of Corporate Governance Guidelines that are designed to help ensure effective corporate governance of our Company. Our Corporate Governance Guidelines cover topics including, but not limited to, the size and composition of the Board, Board membership criteria, director qualifications and duties, Board committees, director compensation and director communications with third parties. Succession planning for the Board is critical to our success. Our goal is to achieve a Board that provides

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effective oversight of the Company through the appropriate balance of diversity of perspectives, experience, expertise and skills. Our Corporate Governance Guidelines are reviewed periodically by the Nominating and Corporate Governance Committee, which will recommend any proposed changes to our Board for approval. Our Corporate Governance Guidelines can be found on our website at https://ir.sagimet.com/corporate-governance/governance-overview.

#### BOARD ATTENDANCE, COMMITTEE MEETINGS AND COMMITTEE MEMBERSHIP

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| **DIRECTOR**  | **INDEPENDENCE**  | **BOARD**  | **AC**  | **CC**  | **NCGC**  |
| David Happel | No  | M  |  |  |  |
| George Kemble, Ph.D. | No  | C  |  |  |  |
| Elizabeth Grammer, Esq. | Yes  | M  |  |  | C  |
| Jennifer Jarrett | Yes  | M  | M  |  |  |
| Beth Seidenberg, M.D. | Yes  | LID  |  | C  |  |
| Anne Phillips, M.D. | Yes  | M  |  | M  | M  |
| Paul Hoelscher | Yes  | M  | C  |  |  |
| Timothy P. Walbert | Yes  | M  | M  | M  |  |
| *Total meetings in 2025*  |  | 10  | 4  | 2  | 2  |

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| **AC = Audit Committee** | **CC = Compensation Committee** | **C = Chair** |
| **NCGC = Nominating and Corporate Governance Committee** | **NCGC = Nominating and Corporate Governance Committee** | **M = Member** |
| **LID = Lead independent Director** | **LID = Lead independent Director** | |

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During 2025, our Board held ten meetings, our Compensation Committee held two meetings, our Audit Committee held four meetings and our Nominating and Corporate Governance Committee held two meetings. Each director attended at least 75% of meetings of each Committee on which he or she served in 2025.

Directors are encouraged, but not required, to attend our annual stockholder meetings.

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| **THE AUDIT COMMITTEE**  | **THE AUDIT COMMITTEE**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Chair**: Paul Hoelscher <br> **Additional Committee Members:** <br> &nbsp;&nbsp;&nbsp;&nbsp; • Timothy P. Walbert <br>&nbsp;&nbsp;&nbsp;&nbsp; • Jennifer Jarrett <br>| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Responsible for, among other things: <br> &nbsp;&nbsp;&nbsp;&nbsp; • Helping our Board oversee our corporate accounting and financial reporting processes; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Managing the selection, engagement, qualifications, independence and performance of a qualified firm to serve as the independent registered public accounting firm to audit our financial statements; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Discussing the scope and results of the audit with the independent registered public accounting firm, and reviewing, with management and the independent accountants, our interim and year-end operating results; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Developing procedures for employees to submit concerns anonymously about questionable accounting or audit matters; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Reviewing related person transactions; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Establishing insurance coverage for our officers and directors; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Reviewing significant existing and emerging cybersecurity risks, including material cybersecurity incidents and any disclosure obligations arising from any such incidents; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Obtaining and reviewing a report that describes our internal quality control procedures, any material issues with such procedures, and any steps taken to deal with such issues when required by applicable law; and <br>&nbsp;&nbsp;&nbsp;&nbsp; • Approving or, as permitted, pre-approving audit and permissible non-audit services to be performed by the independent registered public accounting firm.  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; ✓ All members are deemed independent and financially literate under the applicable rules and regulations of the SEC and Nasdaq. <br>✓ Paul Hoelscher and Jennifer Jarrett each qualifies as an audit committee financial expert within the meaning of SEC regulations. <br>| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Responsible for, among other things: <br> &nbsp;&nbsp;&nbsp;&nbsp; • Helping our Board oversee our corporate accounting and financial reporting processes; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Managing the selection, engagement, qualifications, independence and performance of a qualified firm to serve as the independent registered public accounting firm to audit our financial statements; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Discussing the scope and results of the audit with the independent registered public accounting firm, and reviewing, with management and the independent accountants, our interim and year-end operating results; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Developing procedures for employees to submit concerns anonymously about questionable accounting or audit matters; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Reviewing related person transactions; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Establishing insurance coverage for our officers and directors; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Reviewing significant existing and emerging cybersecurity risks, including material cybersecurity incidents and any disclosure obligations arising from any such incidents; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Obtaining and reviewing a report that describes our internal quality control procedures, any material issues with such procedures, and any steps taken to deal with such issues when required by applicable law; and <br>&nbsp;&nbsp;&nbsp;&nbsp; • Approving or, as permitted, pre-approving audit and permissible non-audit services to be performed by the independent registered public accounting firm.  |

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| | |
|:---|:---|
| **THE NOMINATING & CORPORATE GOVERNANCE COMMITTEE**  | **THE NOMINATING & CORPORATE GOVERNANCE COMMITTEE**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Chair**: Elizabeth Grammer <br> **Additional Committee Members:** <br> &nbsp;&nbsp;&nbsp;&nbsp; • Anne Phillips <br>| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Responsible for, among other things: <br> &nbsp;&nbsp;&nbsp;&nbsp; • Identifying and evaluating candidates to serve on our Board, including the incumbent directors to be nominated for reelection and nominees recommended by stockholders; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Considering and making recommendations to our Board regarding the composition and chairmanship of the committees of our Board; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Reviewing and recommending to the Board corporate succession plans for our Chief Executive Officer and other executive officers; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Ensuring the continuing education of our Board and orientation of new directors; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Developing and making recommendations to our Board regarding corporate governance guidelines and matters; and <br>&nbsp;&nbsp;&nbsp;&nbsp; • Overseeing periodic evaluations of the Board's performance, including committees of the Board and management.  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; ✓ All members are deemed independent and financially literate under the applicable rules and regulations of the SEC and Nasdaq. <br>| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Responsible for, among other things: <br> &nbsp;&nbsp;&nbsp;&nbsp; • Identifying and evaluating candidates to serve on our Board, including the incumbent directors to be nominated for reelection and nominees recommended by stockholders; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Considering and making recommendations to our Board regarding the composition and chairmanship of the committees of our Board; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Reviewing and recommending to the Board corporate succession plans for our Chief Executive Officer and other executive officers; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Ensuring the continuing education of our Board and orientation of new directors; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Developing and making recommendations to our Board regarding corporate governance guidelines and matters; and <br>&nbsp;&nbsp;&nbsp;&nbsp; • Overseeing periodic evaluations of the Board's performance, including committees of the Board and management.  |

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| | |
|:---|:---|
| **THE COMPENSATION COMMITTEE**  | **THE COMPENSATION COMMITTEE**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Chair**: Beth Seidenberg <br> **Additional Committee Members:** <br> &nbsp;&nbsp;&nbsp;&nbsp; • Timothy P. Walbert <br>&nbsp;&nbsp;&nbsp;&nbsp; • Anne Phillips <br>| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Responsible for, among other things: <br> &nbsp;&nbsp;&nbsp;&nbsp; • Reviewing and recommending to our Board the compensation paid to our directors; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Reviewing and approving the compensation arrangements with our executive officers and other senior management and recommending to our Board compensation arrangements for our Chief Executive Officer; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Administering our equity incentive plans and other benefit programs; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Reviewing, adopting, amending and terminating, incentive compensation and equity plans, severance agreements, compensation recovery plans, profit sharing plans, bonus plans, change-of-control protections and any other compensatory arrangements for our executive officers and other senior management; and <br>&nbsp;&nbsp;&nbsp;&nbsp; • Reviewing and establishing general policies relating to compensation and benefits of our employees, including our overall compensation philosophy.  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; ✓ All members are deemed independent and financially literate under the applicable rules and regulations of the SEC and Nasdaq. <br>✓ All members are nonemployee directors as defined by SEC rules <br>| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Responsible for, among other things: <br> &nbsp;&nbsp;&nbsp;&nbsp; • Reviewing and recommending to our Board the compensation paid to our directors; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Reviewing and approving the compensation arrangements with our executive officers and other senior management and recommending to our Board compensation arrangements for our Chief Executive Officer; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Administering our equity incentive plans and other benefit programs; <br>&nbsp;&nbsp;&nbsp;&nbsp; • Reviewing, adopting, amending and terminating, incentive compensation and equity plans, severance agreements, compensation recovery plans, profit sharing plans, bonus plans, change-of-control protections and any other compensatory arrangements for our executive officers and other senior management; and <br>&nbsp;&nbsp;&nbsp;&nbsp; • Reviewing and establishing general policies relating to compensation and benefits of our employees, including our overall compensation philosophy.  |

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#### COMPENSATION CONSULTANT
Aon plc, or Aon, serves as our independent compensation consultant. When requested, Aon consultants attend meetings of our Compensation Committee, including executive sessions in which executive compensation-related matters are discussed without the presence of our management. Aon reports to our Compensation Committee and not to our management, although Aon meets with our management for purposes of gathering information for its analyses and recommendations.

Our Compensation Committee assessed the independence of Aon from management, taking into consideration relevant factors, including the absence of other services provided to our Company by Aon, the amount of fees our Company paid to Aon as a percentage of Aon's total revenue, the policies and procedures of Aon that are designed to prevent conflicts of interest, any business or personal relationship of the individual compensation advisors employed by Aon with any executive officer of the Company, any business or personal relationship the individual compensation advisors employed by Aon have with any member of our Compensation Committee and any stock of our Company owned by Aon or the individual compensation advisors employed by Aon. On the basis of that assessment and taking into consideration the independence factors that are required to be considered under applicable stock exchange rules, our Compensation Committee determined that no relationships existed that would create a conflict of interest or that would compromise Aon's independence, and that Aon is independent pursuant to the independence standards set forth in the Nasdaq listing standards promulgated pursuant to Section 10C of the Securities Exchange Act of 1934, or the Exchange Act.

#### COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION
None of the members of the Compensation Committee is currently one of our officers or employees. None of our officers currently serves, or has served during the last calendar year, as a member of the board or compensation committee of any company that has one or more executive officers serving as a member of our Board or Compensation Committee.

#### FAMILY RELATIONSHIPS
There are no family relationships among any of our directors or executive officers.

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#### STOCKHOLDER ENGAGEMENT
We regularly connect, collaborate and communicate with our stockholders.

![[MISSING IMAGE: fc_connect-4c.jpg]](fc_connect-4c.jpg)

#### Connect
Engaging with investors is fundamental to our commitment to good corporate governance and essential to maintaining strong corporate governance practices. Throughout the year, we seek opportunities to connect with our investors to gain and share valuable insights into current and emerging global governance trends.

#### Collaborate
We strive for a collaborative approach to stockholder engagement and value the variety of investors' perspectives received, which helps deepen our understanding of their interests and motivations.

#### Communicate
Our goal is to communicate with our stockholders through various platforms, including via our website at www.sagimet.com, in print and in person at investor presentations or stockholder meetings. We view communication between our stockholders and the Board as a dialogue.

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| | |
|:---|:---|
| **HOW TO COMMUNICATE WITH OUR DIRECTORS**  | By mail: <br> Corporate Secretary <br> Sagimet Biosciences Inc. <br> 155 Bovet Road, Suite 303 <br> San Mateo, California 94402 <br> By email: <br> ir@sagimet.com  |

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#### DIRECTOR COMPENSATION
We have designed and implemented our compensation program for our non-employee directors to attract, motivate and retain individuals who are committed to our values and goals and who have the expertise and experience that we need to achieve those goals.

#### NON-EMPLOYEE DIRECTOR COMPENSATION POLICY
Our Board has adopted a non-employee director compensation policy. The policy is designed to enable us to attract and retain, on a long-term basis, highly qualified non-employee directors. Under the policy, our non-employee directors are eligible to receive cash retainers (which will be payable quarterly in arrears and prorated for partial years of service) and equity awards as set forth below, provided that our non-employee directors may opt to receive their cash retainers in fully vested shares of our Series A common stock:

#### Annual Retainer for Board membership
The annual retainer for Board membership is $40,000 for general availability and participation in meetings and conference calls of our Board.

#### Annual Retainer for Lead Independent Director
The annual retainer for service as our Lead Independent Director is $25,000.

#### Additional Annual Retainer for Committee Membership

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| | |
|:---|:---|
| Audit Committee Chairperson: | $15000 |
| Audit Committee member (other than Chairperson): | $7500 |
| Compensation Committee Chairperson: | $10000 |
| Compensation Committee member (other than Chairperson): | $5000 |
| Nominating and Corporate Governance Committee Chairperson: | $10000 |
| Nominating and Corporate Governance Committee member (other than Chairperson): | $4500 |
| Additional retainer for non-executive Chairperson of the Board: | $30000 |

---

In addition, the non-employee director compensation policy provides that, upon initial election or appointment to our Board, each non-employee director will be granted an equity award consisting of a stock option to purchase 46,700 shares of Series A Common Stock (up to a maximum grant date fair value of $230,100), or the Initial Grant. The Initial Grant will vest in equal monthly installments over three years following the grant date, subject to continued service through the applicable vesting date. Furthermore, on the date of each annual meeting of stockholders, each non-employee director will be granted a stock option to purchase 43,150 shares of Series A Common Stock (up to a maximum grant date fair value of $130,050), or the Annual Grant. The Annual Grant will vest in equal monthly installments over one year following the grant date, subject to continued service through the applicable vesting date. If a non-employee director joins our Board on a date other than the date of the annual meeting of stockholders, then such non-employee director will be granted a prorated portion of the Annual Grant corresponding to such partial year of service at the next annual meeting of stockholders. The Initial Grant and the Annual Grant are subject to full accelerated vesting upon the sale of the Company.

The aggregate amount of compensation, including both equity compensation and cash compensation, paid to any non-employee director for service as a non-employee director in a calendar year period will not exceed $750,000 in the first calendar year such individual becomes a non-employee director and $500,000 in any other calendar year.

We reimburse all reasonable out-of-pocket expenses incurred by directors for their attendance at meetings of our Board or any committee thereof.

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#### 2025 DIRECTOR COMPENSATION TABLE
The following table below sets forth information for the fiscal year ended December 31, 2025 regarding the compensation of our non-employee directors.

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| | | | | |
|:---|:---|:---|:---|:---|
| **Name**  | **Fees Earned <br> or Paid in <br> Cash <br> ($)**  | **Stock <br> Awards <br> ($)<sup>(1)</sup>**  | **All other <br> compensation <br> ($)<sup>(1)</sup>**  | **Total <br> ($)**  |
| Elizabeth Grammer<sup>(2)</sup> | 50000 | 129864 |  | 179864 |
| Paul Hoelscher<sup>(3)</sup> | 55000 | 129864 |  | 184864 |
| Beth Seidenberg, M.D.<sup>(4)</sup> | 66331 | 129864 | 120083 | 316278 |
| Anne Phillips, M.D.<sup>(5)</sup> | 47306 | 109803 |  | 157109 |
| Jennifer Jarrett<sup>(6)</sup> | 47500 | 109803 |  | 157303 |
| Timothy P. Walbert<sup>(7)</sup> | 52500 | 129864 |  | 182364 |
| George Kemble, Ph.D.<sup>(8)</sup> | 45726 | 129864 |  | 175590 |
| Merdad Parsey, M.D., Ph.D.<sup>(9)</sup> | 21863 |  |  | 21863 |

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(1) Amounts shown in this column do not reflect dollar amounts actually received by our directors. Instead, these amounts reflect the aggregate grant date fair value of each stock option granted in 2025, calculated in accordance with Topic 718 in the Financial Accounting Standards Board's Accounting Standards Codification, or FASB ASC Topic 718. Such grant date fair values do not take into account any estimated forfeitures. The assumptions used in calculating the grant date fair values of the restricted stock units reported in this column are set forth in note 2 of our financial statements included in our 2025 Annual Report.

(2) As of December 31, 2025, Ms. Grammer held 133,242 unexercised stock options.

(3) As of December 31, 2025, Mr. Hoelscher held 114,543 unexercised stock options.

(4) As of December 31, 2025, Dr. Seidenberg held 135,447 unexercised stock options. All other compensation includes a grant of stock options as compensation in accordance with the consulting agreement entered into between the Company and Dr. Seidenberg on June 6, 2025.

(5) As of December 31, 2025, Dr. Phillips held 141,163 unexercised stock options.

(6) As of December 31, 2025, Ms. Jarrett held 141,163 unexercised stock options.

(7) As of December 31, 2025, Mr. Walbert held 114,543 unexercised stock options.

(8) Dr. Kemble transitioned from his executive officer position as Executive Chairman into the role of non-executive Chair of the Board in May 2026. As of December 31, 2025, Dr. Kemble held 994,011 unexercised stock options and 75,375 unvested restricted stock units.

(9) Dr. Parsey Served on our Boad until June 2025.

In addition, we have reimbursed and will continue to reimburse all of our non-employee directors for their reasonable out-of-pocket expenses incurred in attending Board and committee meetings.

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#### INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

#### INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FEES
The Audit Committee works with our management in order to negotiate appropriate fees with KPMG and is ultimately responsible for approving those fees. Deloitte & Touche LLP, or Deloitte, was our independent registered public accounting firm until August 18, 2025, and KPMG succeeded Deloitte as our independent registered public accounting firm as of that date. The following is a summary and description of fees for services provided by KPMG and Deloitte, in 2025 and 2024, respectively.

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| | | | |
|:---|:---|:---|:---|
| **SERVICE**  | **2025 ($)<sup>(1)</sup>**  | **2025 ($)<sup>(2)</sup>**  | **2024 ($)<sup>(3)</sup>**  |
| Audit Fees | 529153 | 346752 | 1173300 |
| Audit-Related Fees |  |  |  |
| Tax Fees |  |  | 10800 |
| All Other Fees |  |  |  |
| **Total**  | 529153 | 346752 | 1184100 |

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(1) Represents fees for professional services rendered by KPMG for fiscal year 2025.

(2) Represents fees for professional services rendered by Deloitte for fiscal year 2025.

(3) Represents fees for professional services rendered by Deloitte for fiscal year 2024.

"**Audit fees**" represents the aggregate fees for professional services rendered for the audit of our financial statements and the review of our quarterly financial statements on Form 10-Q that are customary under the standards of the Public Company Accounting Oversight Board (United States), or the PCAOB by KPMG and Deloitte for the year ended December 31, 2025 and by Deloitte for the year ended December 31, 2024. Also included are the fees related to our Registration Statements on Form S-1, Form S-3 (each with respect to Deloitte only), Form S-8 and for comfort letter procedures.

**"Audit Related Fees"** represents the aggregate fees billed by KPMG and Deloitte for the year ended December 31, 2025 and to Deloitte for the year ended December 31, 2024 for assurance and related services that are reasonably related to the performance of the audit or review of our financial statements and are not reported under "Audit fees" above.

"**Tax fees**" consists of fees billed by Deloitte for the year ended December 31, 2024 related to tax compliance, tax planning and tax advice.

#### AUDIT COMMITTEE PRE-APPROVAL POLICIES AND PROCEDURES
The Audit Committee is responsible for appointing, retaining, setting compensation for, and evaluating and overseeing the work of the independent registered public accounting firm. The Audit Committee's charter establishes a policy that all audit and permissible non-audit services provided by the independent registered public accounting firm will be pre-approved by the Audit Committee.

The services provided by KPMG and Deloitte for the year ended December 31, 2025 and by Deloitte for the year ended December 31, 2024 were provided under engagements entered into in accordance with such pre-approval policies. These services may include audit services, audit-related services, tax services and other services. The Audit Committee considers whether the provision of each non-audit service is compatible with maintaining the independence of our independent registered public accounting firm.

#### CHANGE IN INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
As previously disclosed in a Current Report on Form 8-K filed with the SEC on August 18, 2025, or the Auditor 8-K, the Audit Committee of the Board approved (i) the appointment of KPMG as our independent registered public accounting firm for the fiscal year ending December 31, 2025 and related interim periods and, concurrently, (ii) the dismissal of Deloitte as the Company's independent registered public accounting firm, effective immediately.

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The audit reports of Deloitte on the Company's financial statements as of December 31, 2024 and December 31, 2023, did not contain an adverse opinion or a disclaimer of opinion, and were not qualified or modified as to uncertainty, audit scope, or accounting principles. Furthermore, during the two fiscal years ended December 31, 2024 and December 31, 2023, and the subsequent interim period through August 18, 2025, there were no disagreements with Deloitte on any matter of accounting principles or practices, financial statement disclosure, or auditing scope or procedure, which disagreements, if not resolved to the satisfaction of Deloitte, would have caused it to make a reference in connection with its opinion to the subject matter of the disagreement or reportable events as defined in Item 304(a)(1)(v) of Regulation S-K.

During the two fiscal years ended December 31, 2024 and December 31, 2023, and the subsequent interim period through August 18, 2025, KPMG has not been engaged as either the principal accountant to audit the Company's financial statements, or as an independent accountant to audit a significant subsidiary of the Company. During the two fiscal years, ended December 31, 2024 and December 31, 2023, and the subsequent interim period through August 18, 2025, neither the Company nor anyone on the Company's behalf consulted KPMG regarding (i) the application of accounting principles to a specified transaction, either completed or proposed, or the type of audit opinion that might be rendered on the Company's financial statements, and no written report or oral advice was provided to the Company by KPMG that KPMG concluded was an important factor considered by the Company in reaching a decision as to the accounting, auditing or financial reporting issue; or (ii) any matter that was either the subject of a disagreement within the meaning of Item 304(a)(1)(iv) of Regulation S-K, or a reportable event within the meaning of Item 304(a)(1)(v) of Regulation S-K.

We provided Deloitte with a copy of the foregoing disclosures and received a letter from Deloitte addressed to the SEC, stating that it agreed with such disclosures. The letter was filed as an exhibit to the Auditor 8-K.

A representative of KPMG will attend the Annual Meeting. Such representative will have an opportunity to make a statement, if he or she desires, and will be available to response to appropriate questions of stockholders.

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#### AUDIT COMMITTEE REPORT
The Audit Committee is appointed by the Board to assist the Board in fulfilling its oversight responsibilities with respect to (1) the integrity of the Company's financial statements and financial reporting process and systems of internal controls regarding finance, accounting, and compliance with legal and regulatory requirements, (2) the qualifications, independence, and performance of the Company's independent registered public accounting firm, (3) the performance of the Company's internal audit function, if any, and (4) other matters as set forth in the charter of the Audit Committee approved by the Board.

Management is responsible for the preparation of the Company's financial statements and the financial reporting process, including its system of internal control over financial reporting and its disclosure controls and procedures. The independent registered public accounting firm is responsible for performing an audit of the Company's financial statements in accordance with the standards of the PCAOB and issuing a report thereon. The Audit Committee's responsibility is to monitor and oversee these processes.

In connection with these responsibilities, the Audit Committee reviewed and discussed with management and the independent registered public accounting firm the audited financial statements of the Company for the fiscal year ended December 31, 2025. The Audit Committee also discussed with the independent registered public accounting firm the matters required to be discussed by the PCAOB's Auditing Standard No. 1301, Communication with Audit Committees. In addition, the Audit Committee received written communications from the independent registered public accounting firm confirming their independence as required by the applicable requirements of the PCAOB and has discussed with the independent registered public accounting firm their independence.

Based on the reviews and discussions referred to above, the Audit Committee recommended to the Board that the audited consolidated financial statements of the Company be included in the Company's 2025 Annual Report. The information contained in this report shall not be deemed to be (1) "soliciting material," (2) "filed" with the SEC, (3) subject to Regulations 14A or 14C of the Exchange Act, or (4) subject to the liabilities of Section 18 of the Exchange Act. This report shall not be deemed incorporated by reference into any of our other filings under the Exchange Act or the Securities Act of 1933, as amended, or the Securities Act, except to the extent that we specifically incorporate it by reference into such filing.

#### THE AUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF SAGIMET BIOSCIENCES INC.
Paul Hoelscher, Chair

Jennifer Jarrett

Timothy P. Walbert

April 21, 2026

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#### EXECUTIVE OFFICERS
The following table sets forth the name, age and position of each of our executive officers as of the date of this Proxy Statement:

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| | | |
|:---|:---|:---|
| **Name**  | **Age**  | **Position**  |
| *Executive Officers:* |  |  |
| David Happel | 64  | President, Chief Executive Officer and Director  |
| Thierry Chauche | 50  | Chief Financial Officer |
| Eduardo Bruno Martins, M.D., D.Phil. | 63  | Former Chief Medical Officer |
| Elizabeth Rozek, Esq. | 54  | Chief Legal and Administrative Officer |
| Andreas Grauer, M.D. | 65  | Chief Medical Officer |

---

#### Executive Officers
***David Happel*** — For biographical information for Mr. Happel, see "Board of Directors — Director Nominees."

***Eduardo Bruno Martins, M.D., D.Phil.*** served as our Chief Medical Officer from February 2021 to April 2026. In September 2017, Dr. Martins co-founded Bruno Martins Consulting LLC, a consulting firm that provides scientific advice and services to biotechnology and pharmaceutical companies. From May 2020 to December 2020, prior to joining us, he served as Vice President of Clinical Development at Abbvie Inc. Prior to that, from August 2018 to May 2020, he served as Vice President of Clinical Development — Liver Disease for Allergan, Inc. From November 2015 to August 2017, Dr. Martins served as Senior Vice President of Liver and Infectious Disease Drug Development at Eiger Biopharmaceuticals, Inc. From December 2010 to October 2015, he also served as Senior Director of Medical Affairs for Hepatitis at Gilead Sciences, Inc. Dr. Martins received his M.D. from the Universidade Federal do Rio de Janeiro in Rio de Janeiro, Brazil and his D.Phil. from the University of Oxford in Oxford, England.

***Thierry Chauche*** has served as our Chief Financial Officer since May 2024. Mr. Chauche has over 25 years of financial and operational leadership experience in finance and healthcare companies. He previously served as the Chief Financial Officer of Provention Bio, Inc., from December 2021 until it was acquired by Sanofi S.A. in April 2023. From 2021 to 2021, Mr. Chauche served as the Vice President and Head of Strategic Financial Planning & Analysis at Alexion Pharmaceuticals, Inc. Prior to this, Mr. Chauche served in roles of increasing responsibility at Intercept Pharmaceuticals, Inc. from 2017 to 2020, Novartis AG from 2007 to 2017, and Rothschild & Cie from 1999 to 2005. Mr. Chauche holds an M.S. in engineering from Ecole Des Ponts ParisTech and an MBA from the Wharton School of the University of Pennsylvania.

***Elizabeth Rozek, Esq.*** has served as our Chief Legal and Administrative Officer since November 2025. Prior to this role, she served as our General Counsel and Chief Compliance Officer from April 2023 to November 2025. From December 2020 to December 2022, Ms. Rozek served as General Counsel and Chief Compliance Officer of Cognoa, Inc. From January 2010 to April 2023, she held various counsel positions at Basilea Pharmaceutica International Ltd., a Swiss-listed biopharmaceutical company with global operations, including Litigation Counsel (January 2010 to July 2010), General Counsel and Corporate Secretary (March 2011 to July 2017), Advisory External Counsel (August 2017 to December 2020), and Consultant (December 2020 to April 2023). From 2001 to 2006, Ms. Rozek served as a civil prosecutor for the U.S. Department of Justice. Ms. Rozek received her B.A. in literature from Brown University, M.A. in literature from the University of California at San Diego and J.D. from the University of California at Berkeley.

***Andreas Grauer, M.D.*** has served as our Chief Medical Officer since April 2026. Prior to this role, Dr. Grauer most recently served as Chief Medical Officer at Omeros Corporation (NASDAQ: OMER) from October 2023 to April 2026. Prior to Omeros, Dr. Grauer held Chief Medical Officer roles at Federation Bio (October 2021 to July 2023) and Corcept Therapeutics Incorporated (March 2019 to August 2021). Prior to these roles, Dr. Grauer held various positions at Amgen, Inc. (December 2008 to December 2018) including Vice President Global Development. Dr. Grauer began his career at Procter & Gamble Pharmaceuticals (1999 to November 2008). Dr. Grauer continues to serve as an Associate Professor of Medicine at the University of Heidelberg Medical School, Germany, where he received his M.D. and also completed his clinical training in internal medicine and endocrinology.

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#### EXECUTIVE COMPENSATION
The compensation provided to our named executive officers for the year ended December 31, 2025 is detailed in the 2025 summary compensation table and accompanying footnotes and narrative that follow. Our named executive officers for the year ended December 31, 2025 are:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • **David Happel**, president, Chief Executive Officer and director;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • **Elizabeth Rozek, Esq.**, Chief Legal and Administrative Officer; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • **Eduardo Bruno Martins, M.D., D.Phil.**, Former Chief Medical Officer.

#### 2025 Summary Compensation Table
The following table presents all the compensation awarded to, earned by or paid to our named executive officers during the fiscal year ended December 31, 2025.

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| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| **Name and Principal Position**  | **Year**  | **Salary <br> ($)<sup>(1)</sup>**  | **Stock <br> Awards <br> ($)<sup>(2)</sup>**  | **Option <br> Awards <br> ($)<sup>(3)</sup>**  | **Non-Equity <br> Incentive Plan <br> Compensation <br> ($)<sup>(4)</sup>**  | **All Other <br> Compensation <br> ($)<sup>(5)</sup>**  | **Total ($)**  |
|  David Happel <br> *President and Chief Executive Officer*  | 2025 | 630000 | 546360 | 1749751 | 294525 | 19358 | 3239994 |
|  David Happel <br> *President and Chief Executive Officer*  | 2024 | 582000 |  |  | 320100 | 4064 | 906164 |
|  Elizabeth Rozek, Esq. <br> *Chief Legal and Administrative Officer*  | 2025 | 483333 | 235137(6) | 591668(6) | 170000 | 16564 | 1496702 |
|  Elizabeth Rozek, Esq. <br> *Chief Legal and Administrative Officer*  | 2024 | 446000 |  |  | 178400 | 1742 | 626142 |
|  Eduardo Bruno Martins, M.D., D.Phil., <br> *Former Chief Medical Officer*<sup>(7)</sup>  | 2025 | 500000 | 160140 | 511580 | 170000 | 19121 | 1360841 |
|  Eduardo Bruno Martins, M.D., D.Phil., <br> *Former Chief Medical Officer*<sup>(7)</sup>  | 2024 | 475000 |  |  | 190000 | 4064 | 669064 |

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(1) The amounts reported reflect annual salary adjustments that were made during 2024 and 2025. For more information, see "Annual base salary" below.

(2) The amounts reported represent the aggregate grant date fair value of the restricted stock units granted to our named executive officers in the applicable year, calculated in accordance with FASB ASC Topic 718. Such grant date fair values do not take into account any estimated forfeitures. The assumptions used in calculating the grant date fair values of the restricted stock units reported in this column are set forth in note 2 of our financial statements included in our 2025 Annual Report . These amounts reported in this column reflect the accounting cost for these restricted stock units and do not correspond to the economic value that may be received by our named executive officers upon vesting and settlement of such awards or any sale of the shares of our Series A common stock received.

(3) The amounts reported represent the aggregate grant date fair value of the stock options granted to our named executive officers in the applicable year, calculated in accordance with FASB ASC Topic 718. Such grant date fair values do not take into account any estimated forfeitures. The assumptions used in calculating the grant date fair values of the stock options reported in this column are set forth in note 2 of our financial statements included in our 2025 Annual Report. These amounts reported in this column reflect the accounting cost for these stock options and do not correspond to the economic value that may be received by our named executive officers upon the exercise of such awards or any sale of the underlying shares of our Series A common stock.

(4) The amounts reported reflect performance-based cash bonus payments awarded based on the achievement of certain corporate performance goals. All of the bonuses earned by our named executive officers in 2024 were paid in cash in 2025 and all of the bonuses earned by our named executive officers in 2025 were paid in cash in 2026.

(5) The amounts reported include life insurance premium payments made in 2024 and 2025 for Mr. Happel, Ms. Rozek and Dr. Martins in the amount of $3,564, $1,242 and $3,564, respectively. The amounts reported included matching contributions that we made under our 401(k) plan in 2025 in the amount

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of $14,000 for each of Mr. Happel, Ms. Rozek and Dr. Martins. The amounts reported in 2024 for each of Messrs. Happel, Rozek and Dr. Martins includes a $500 annual holiday gift card (for 2023 holidays) offered to all of our employees. The amounts reported in 2025 for each of Mr. Happel, Ms. Rozek and Dr. Martins includes two $500 annual holiday gift cards (for 2024 and 2025 holidays) offered to all of our employees, along with a tax gross-up associated with the gift cards of $794, $322 and $557, respectively.

(6) The amounts reported include 9,855 restricted stock units and 13,367 options granted to Ms. Rozek in November 2025 in connection with Ms. Rozek's promotion to Chief Legal and Administrative Officer.

(7) Dr. Martin's announced his retirement effective as of April 20, 2026.

#### Narrative to the Summary Compensation Table
Our Compensation Committee reviews and approves compensation annually for all employees, including our named executive officers, with the exception of our Chief Executive Officer. The Compensation Committee reviews and recommends the Chief Executive Officer's compensation to the Board for approval. In making compensation determinations, we consider compensation for comparable positions in the market, the historical compensation levels of our executives, individual performance as compared to our expectations and objectives, our desire to motivate our employees to achieve short- and long-term results that are in the best interests of our stockholders and a long-term commitment to our Company.

#### Annual Base Salary
Base salaries for our executive officers are initially established through arm's-length negotiations at the time of the executive officer's hiring, taking into account such executive officer's qualifications, experience, the scope of his or her responsibilities and competitive market compensation paid by other companies for similar positions within the industry and geography. Base salaries are reviewed periodically, typically in connection with our annual performance review process, and adjusted from time to time to realign salaries with market levels after taking into account individual responsibilities, performance and experience. In making decisions regarding salary increases, we may also draw upon the experience of members of our Board with executives at other companies.

The 2024 annual base salaries in effect on January 1, 2024 for Mr. Happel Ms. Rozek and Dr. Martins were $582,000, $446,000 and $475,000, respectively.

The 2025 annual base salaries in effect on January 1, 2025 for Mr. Happel, Ms. Rozek and Dr. Martins were $630,000, $480,000 and $500,000, respectively.

In February 2026, our Compensation Committee approved, and in the case of Mr. Happel, our Compensation Committee recommended and our Board approved, annual base salaries effective January 1, 2026 for Mr. Happel, Ms. Rozek and Dr. Martins in the amounts of $654,000, $500,000 and $500,000, respectively.

#### Performance Bonuses
During the year ended December 31, 2025, our named executive officers were each eligible to earn an annual bonus based on the achievement of certain individual objectives and company performance objectives. For the fiscal year ended December 31, 2025, the target annual bonuses for Mr. Happel, Ms. Rozek and Dr. Martins were 55%, 40% and 40%, respectively.

For 2025, our named executive officers were eligible to earn their annual bonus pursuant to the achievement of corporate goals approved by our Board. These goals primarily related to the clinical development of denifanstat, pipeline and platform development, financing and operations. The Board determined that the 2025 corporate goals were achieved at 85%. Following a review of 2025 performance, our Compensation Committee approved, and, in the case of Mr. Happel, our Compensation Committee recommended and our Board approved, 2025 annual bonus payouts to each of Mr. Happel, Ms. Rozek and Dr. Martins equal to $294,525, $170,000 and $170,000, respectively, in each case representing 85% of the target cash incentive for each such named executive officer.

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#### Equity Compensation
We believe that equity awards provide our executive officers with a strong link to our long-term performance, create an ownership culture and help to align the interests of our executives and stockholders. In addition, we believe that equity awards with a time-based vesting feature promote executive retention because this feature incentivizes our executive officers to remain in our employment during the applicable vesting period. Accordingly, our Board periodically reviews the equity incentive compensation of our named executive officers and from time to time may grant equity incentive awards to them.

#### Annual Equity Awards
In 2024, we did not make annual equity grants to our named executive officers.

In February 2025, our Compensation Committee approved, and in the case of Mr. Happel, our Compensation Committee recommended and our Board approved, grants of options and restricted stock units to each of our named executive officers. We granted options to purchase 472,000, 138,000 and 138,000 shares of Series A common stock and 116,000, 34,000 and 34,000 restricted stock units to each of Mr. Happel, Ms. Rozek and Dr. Martins, respectively. The options vest over forty-eight equal monthly installments, subject to each named executive officer's continued service on each such vesting date. The restricted stock units vest over four equal annual installments, subject to each named executive officer's continued service on each such vesting date.

In February 2026, our Compensation Committee approved, and in the case of Mr. Happel, our Compensation Committee recommended and our Board approved, grants of options and restricted stock units to each of our named executive officers. We granted options to purchase 256,000, 88,000 and 88,000 shares of Series A common stock and 128,000, 44,000 and 44,000 restricted stock units to each of Mr. Happel, Ms. Rozek and Dr. Martins, respectively. The options vest over forty-eight equal monthly installments, subject to each named executive officer's continued service on each such vesting date. The restricted stock units vest over four equal annual installments, subject to each named executive officer's continued service on each such vesting date.

#### Inducement Equity Awards
Our Board established a pool of shares of Series A common stock from which grants can be issued with Compensation Committee approval but without stockholder approval as inducement for new employees to accept employment offers from the Company under Nasdaq Listing Rule 5635(c)(4). Inducement grants to new employees are determined on a case-by-case basis.

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#### Outstanding Equity Awards as of December 31, 2025
The following table presents the outstanding equity awards held by each named executive officer as of December 31, 2025:

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| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| | | **Option Awards<sup>(1)</sup>**  | **Option Awards<sup>(1)</sup>**  | **Option Awards<sup>(1)</sup>**  | **Option Awards<sup>(1)</sup>**  | **Stock Awards**  | **Stock Awards**  |
| | **Grant Date<sup>(2)</sup>**  | **Number of <br> Securities <br> Underlying <br> Unexercised <br> Options <br> Exercisable <br> (#)**  | **Number of <br> Securities <br> Underlying <br> Unexercised <br> Options <br> Unexercisable <br> (#)**  | **Option <br> Exercise <br> Price Per <br> Share <br> ($)<sup>(3)</sup>**  | **Option <br> Expiration <br> Date**  | **Number of <br> shares or <br> units of <br> stock that <br> have not <br> vested <br> (#)**  | **Market value <br> of shares or <br> units of <br> stock that <br> have not <br> vested <br> ($)<sup>(4)</sup>**  |
| David Happel <br>10/17/2022<sup>(5</sup>) |  | 801040 | 210786 | $7.15 | 10/16/2032 |  |  |
| David Happel <br>11/17/2023<sup>(6</sup>) |  |  |  |  |  | 312455 | $1849734 |
| David Happel <br>2/6/2025<sup>(7</sup>) |  | 98333 | 373667 | $4.71 | 2/5/2035 |  |  |
| David Happel <br>2/6/2025<sup>(8</sup>) |  |  |  |  |  | 116000 | $686720 |
| Elizabeth Rozek <br>4/20/2023<sup>(9</sup>) |  | 161438 | 80704 | $13.51 | 4/19/2033 |  |  |
| Elizabeth Rozek <br>11/17/2023<sup>(6</sup>) |  |  |  |  |  | 85710 | $507403 |
| Elizabeth Rozek <br>2/6/2025<sup>(7</sup>) |  | 28750 | 109250 | $4.71 | 2/5/2035 |  |  |
| Elizabeth Rozek <br>2/6/2025<sup>(8</sup>) |  |  |  |  |  | 34000 | $201280 |
| Elizabeth Rozek <br>11/4/2025<sup>(7</sup>) |  | 278 | 13089 | $7.61 | 11/3/2035 |  |  |
| Elizabeth Rozek <br>11/4/2025<sup>(8</sup>) |  |  |  |  |  | 9855 | $58342 |
|  Eduardo Bruno <br> Martins, M.D., <br> D.Phil. <br>2/19/2021<sup>(5</sup>) |  | 198132 |  | $6.36 | 2/18/2031 |  |  |
|  Eduardo Bruno <br> Martins, M.D., <br> D.Phil. <br>4/20/2023<sup>(7</sup>) |  | 29344 | 14665 | $13.51 | 4/19/2033 |  |  |
|  Eduardo Bruno <br> Martins, M.D., <br> D.Phil. <br>11/17/2023<sup>(6</sup>) |  |  |  |  |  | 44785 | $265127 |
|  Eduardo Bruno <br> Martins, M.D., <br> D.Phil. <br>2/6/2025<sup>(7</sup>) |  | 28750 | 109250 | $4.71 | 2/5/2035 |  |  |
|  Eduardo Bruno <br> Martins, M.D., <br> D.Phil. <br>2/6/2025<sup>(8</sup>) |  |  |  |  |  | 34000 | $201280 |

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(1) All of the options, except as noted in the footnotes below, were granted under the 2017 Equity Incentive Plan, or the 2017 Plan or the 2023 Plan (each as defined below), the terms of which are described below under "Executive Compensation — Equity Benefit Plans — 2017 Equity Incentive Plan" and "Executive Compensation — Equity Benefit Plans — 2023 Equity Incentive Plan."

(2) Except where otherwise noted, if within the twelve-month period that immediately follows a change of control (as defined in the named executive officer's employment agreement) the named executive officer's employment is terminated without cause or the named executive officer resigns for good reason (as defined in the named executive officer's employment agreement), then 100% of the award shall accelerate and become fully vested as of the termination date.

(3) Prior to our IPO, all of the option awards were granted with a per share exercise price equal to the fair market value of one share of our Series A common stock on the date of grant, as determined in good faith by our Board or Compensation Committee. Following our IPO, all of the option awards were granted with a per share exercise price equal to the closing price of our Series A on the date of grant.

(4) The market value is based on the closing stock price of $5.92 on December 31, 2025.

(5) 25% of the shares subject to the option vest one year after the vesting commencement date and 1/48th of the shares subject to the option vest monthly thereafter subject to the named executive officer's continued service through each vesting date.

(6) The restricted stock units vest in four equal annual installments beginning July 18, 2024, subject to the named executive officer's continued service to our Company through each vesting date.

(7) 1/48th of the shares subject to the option vest monthly following the vesting commencement date, subject to the named executive officer's continued service through each vesting date.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

(8) The restricted stock units vest in four equal annual installments following the vesting commencement date, subject to the named executive officer's continued service to our Company through each vesting date.

(9) 25% of the shares subject to the option vest one year after the vesting commencement date and 1/36th of the shares subject to the option vest monthly thereafter subject to the named executive officer's continued service through each vesting date.

#### 401(k) Plan
We maintain a defined contribution employee retirement plan, or the 401(k) Plan, for our employees. The 401(k) Plan is intended to qualify as a tax-qualified plan under Section 401(a) of the Code. The 401(k) Plan covers all employees, including our named executive officers, who meet defined minimum age and service requirements and allows participants to defer a portion of their annual compensation on a pre-tax basis. The 401(k) Plan provides that each eligible participant may contribute up to the lesser of 100% of his or her compensation or the statutory limit. Participant contributions are held and invested, pursuant to the participant's instructions, by the plan's trustee. As a tax-qualified retirement plan, contributions to the 401(k) Plan are deductible by us when made, and contributions and earnings on those amounts are not generally taxable to the employees until withdrawn or distributed from the 401(k) Plan. As of January 1, 2025, we match up to 100% of eligible employees contributions up to 4% of eligible compensation under the 401(k) Plan.

#### Nonqualified Deferred Compensation
We do not maintain nonqualified defined contribution plans or other nonqualified deferred compensation plans. Our Board may elect to provide our officers and other employees with nonqualified defined contribution or other nonqualified deferred compensation benefits in the future if it determines that doing so is in our best interests.

#### Employment Arrangements
We have entered into employment agreements with each of our named executive officers providing for base salary, cash incentives, equity incentives, severance, and certain other benefits and payments. Below are descriptions of our executive employment agreements and other agreements with our named executive officers.

*Mr. Happel.* On August 15, 2023, we entered into an employment agreement with David Happel, which was effective as of July 19, 2023, and subsequently amended and restated on June 5, 2024 and further amended and restated on June 6, 2025, or the Happel Employment Agreement. The payments and benefits to which Mr. Happel is entitled under the Happel Employment Agreement include: (i) an initial annual base salary that is annually reviewed by the Board and is currently $654,000; (ii) a target annual bonus opportunity equal to 55% of base salary; and (iii) participation in our employee benefit plans that are generally available to our employees.

Pursuant to the Happel Employment Agreement, if we terminate Mr. Happel's employment without "cause" or Mr. Happel resigns for "good reason" (each, as defined in the Happel Employment Agreement) outside of the Change in Control Period (as defined below), Mr. Happel will be entitled to the following severance benefits (in addition to certain accrued but unpaid amounts), subject to his execution of a general release of claims in favor of the Company: (i) a lump sum cash payment equal to 12 months of Mr. Happel's base salary and (ii) the payment by us of premiums for up to 12 months of Consolidated Omnibus Budget Reconciliation Act of 1985, as amended, or COBRA, coverage substantially similar to that provided under our health plan, provided that Mr. Happel properly elects such coverage. In addition, pursuant to the terms of the Happel Employment Agreement, if we terminate Mr. Happel's employment without "cause" or Mr. Happel resigns for "good reason" during the Change in Control Period, Mr. Happel will receive, subject to his execution of a general release of claims in favor of the Company, (i) the sum of (A) 24 months of his base salary; plus (B) an amount equal to 24 months of his target bonus plus (C) his target bonus for the then-current year, prorated to reflect the number of days Mr. Happel worked at the Company during the applicable year; (ii) if Mr. Happel elects coverage under COBRA (or equivalent state law), we

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shall pay to the group health plan provider or COBRA provider of a monthly payment equal to both the monthly employee and the monthly employer contribution that the Company would have made to provide health insurance to Mr. Happel if Mr. Happel had remained employed by the Company until the earliest of (A) the 24 month anniversary of the date of Mr. Happel's termination; (B) the date Mr. Happel becomes eligible for group medical plan benefits under any other employer's group medical plan; or (C) the cessation of Mr. Happel's health continuation rights under COBRA; (iii) all stock options and other stock-based awards held by Mr. Happel that are subject to vesting shall immediately accelerate and become fully vested and exercisable or nonforfeitable; and (iv) all stock options held by Mr. Happel that are vested as of the date of Mr. Happel's termination of employment shall remain exercisable until the earlier of the date that is 12 months following the date of Mr. Happel's termination or the expiration date of such stock option. The "Change in Control Period" is the date of a "change in control" and ending 12 months following the date of such "change in control."

*Ms. Rozek.* On April 4, 2023 we entered into an employment agreement with Elizabeth Rozek. On August 7, 2023, we entered into an executive employment agreement with Ms. Rozek, which was subsequently amended and restated on June 5, 2024 and further on June 6, 2025, or the Rozek Employment Agreement. The payments and benefits to which Ms. Rozek is entitled under the Rozek Employment Agreement include: (i) an initial annual base salary that is annually reviewed by the Board and is currently $500,000; (ii) a target annual bonus opportunity equal to 40% of base salary; and (iii) participation in our employee benefit plans that are generally available to Company employees.

Pursuant to the Rozek Employment Agreement, if we terminate Ms. Rozek's employment without "cause" or Ms. Rozek resigns for "good reason" (each, as defined in the Rozek Employment Agreement) outside of the Change in Control Period (as defined below), Ms. Rozek will be entitled to the following severance benefits (in addition to certain accrued but unpaid amounts), subject to her execution of a general release of claims in favor of the Company: (i) a lump sum cash payment equal to nine months of Ms. Rozek's base salary and (ii) the payment by us of premiums for up to nine months of COBRA coverage substantially similar to that provided under our health plan, provided Ms. Rozek properly elects such coverage. In addition, pursuant to the terms of the Rozek Employment Agreement, if we terminate Ms. Rozek's employment without "cause" or Ms. Rozek resigns for "good reason" during the Change in Control Period, Ms. Rozek will receive, subject to her execution of a general release of claims in favor of the Company, (i) the sum of (A) 15 months of her base salary; plus (B) an amount equal to 15 months of her target bonus; plus (C) her target bonus for the then-current year, prorated to reflect the number of days Ms. Rozek worked at the Company during the applicable year; (ii) if Ms. Rozek elects coverage under COBRA, we shall pay to the group health plan provider or COBRA provider a monthly payment equal to both the monthly employee and the monthly employer contribution that the Company would have made to provide health insurance to Ms. Rozek if she had remained employed by the Company until the earliest of (A) the 15 month anniversary of the date of Ms. Rozek's termination; (B) the date Ms. Rozek become eligible for group medical plan benefits under any other employer's group medical plan; or (C) the cessation of Ms. Rozek's health continuation rights under COBRA; (iii) all stock options and other stock-based awards held by Ms. Rozek that are subject vesting shall immediately accelerate and become fully vested and exercisable or nonforfeitable; and (iv) all stock options held by Ms. Rozek that are vested as of the date of Ms. Rozek's termination of employment shall remain exercisable until the earlier of the date that is 12 months following the date of Ms. Rozek's termination or the expiration date of such stock option. The "Change in Control Period" is the date of a "change in control" and ending 12 months following the date of such "change in control."

*Dr. Martins.* On August 15, 2023, we entered into an employment agreement with Eduardo Martins, which was effective as of July 19, 2023 and subsequently amended and restated on June 5, 2024 and further amended and restated on June 6, 2025, or the Martins Employment Agreement. The payments and benefits to which Dr. Martins is entitled under the Martins Employment Agreement include: (i) an initial annual base salary that is annually reviewed by the Board and is currently $500,000; (ii) a target annual bonus opportunity equal to 40% of base salary; and (iii) participation in our employee benefit plans that are generally available to Company employees.

Pursuant to the Martins Employment Agreement, if we terminate Dr. Martins' employment without "cause" or Dr. Martins resigns for "good reason" (each, as defined in the Martins Employment Agreement)

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outside of the Change in Control Period (as defined below), Dr. Martins will be entitled to the following severance benefits (in addition to certain accrued but unpaid amounts), subject to his execution of a general release of claims in favor of the Company: (i) a lump sum cash payment equal to nine months of Dr. Martins' base salary and (ii) the payment by us of premiums for up to nine months of COBRA coverage substantially similar to that provided under our health plan, provided Dr. Martins properly elects such coverage. In addition, pursuant to the terms of the Martins Employment Agreement, if we terminate Dr. Martins' employment without "cause" or Dr. Martins resigns for "good reason" during the Change in Control Period, Dr. Martins will receive, subject to his execution of a general release of claims in favor of the Company, (i) the sum of (A) 15 months of his base salary; plus (B) an amount equal to 15 months of his target bonus; plus (C) his target bonus for the then-current year, prorated to reflect the number of days Dr. Martins worked at the Company during the applicable year; (ii) if Dr. Martins elects coverage under COBRA, we shall pay to the group health plan provider or COBRA provider a monthly payment equal to both the monthly employee and the monthly employer contribution that the Company would have made to provide health insurance to Dr. Martins if he had remained employed by the Company until the earliest of (A) the 15 month anniversary of the date of Dr. Martins' termination; (B) the date Dr. Martins become eligible for group medical plan benefits under any other employer's group medical plan; or (C) the cessation of Dr. Martins' health continuation rights under COBRA; (iii) all stock options and other stock-based awards held by Dr. Martins that are subject vesting shall immediately accelerate and become fully vested and exercisable or nonforfeitable; and (iv) all stock options held by Dr. Martins that are vested as of the date of Dr. Martins' termination of employment shall remain exercisable until the earlier of the date that is 12 months following the date of Dr. Martins' termination or the expiration date of such stock option. The "Change in Control Period" is the date of a "change in control" and ending 12 months following the date of such "change in control."

#### Other Compensation and Benefits
All of our current named executive officers are eligible to participate in our employee benefit plans, including our medical, dental and vision plans, in each case on the same basis as all of our other employees. We pay the premiums for the medical, disability and accidental death and dismemberment insurance for all of our employees, including our named executive officers. We generally do not provide perquisites or personal benefits to our named executive officers.

#### Equity Benefit Plans

#### 2023 Stock Option and Incentive Plan
The 2023 Stock Option and Incentive Plan, or the 2023 Plan, was adopted by our Board in June 2023, approved by our stockholders in July 2023 and became effective in July 2023 in connection with our IPO. The 2023 Plan provides flexibility to our Compensation Committee to use various equity-based incentive awards as compensation tools to motivate our workforce.

We initially reserved 2,585,968 shares of Series A common stock for the issuance of awards under the 2023 Plan, or the Initial Limit. The 2023 Plan provides that the number of shares reserved and available for issuance under the 2023 Plan will automatically increase each January 1 by 4% of the outstanding number of shares of our Series A common stock on the immediately preceding December 31, or such lesser number of shares as determined by our Compensation Committee, or the Annual Increase. The number of shares reserved under the 2023 Plan is subject to adjustment in the event of a stock split, stock dividend or other change in our capitalization.

The shares issuable under the 2023 Plan are and will be authorized but unissued shares or shares that we reacquire. The shares of Series A common stock underlying any awards under the 2023 Plan that are forfeited, cancelled, held back upon exercise or settlement of an award to satisfy the exercise price or tax withholding, reacquired by us prior to vesting, satisfied without the issuance of stock or are otherwise terminated (other than by exercise) will be added back to the shares of Series A common stock available for issuance under the 2023 Plan.

The maximum aggregate number of shares that may be issued in the form of incentive stock options shall not exceed the Initial Limit, cumulatively increased each January 1 by the lesser of the Annual Increase for such year or shares of Series A common stock.

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The grant date fair value of all awards made under the 2023 Plan and all other cash compensation paid by us to any non-employee director in any calendar year for services as a non-employee director shall not exceed $500,000; provided, however, that such amount shall be $750,000 for the calendar year in which the applicable non-employee director is initially elected or appointed to the Board.

The 2023 Plan is administered by our Compensation Committee. Our Compensation Committee has the full power to select, from among the individuals eligible for awards, the individuals to whom awards will be granted and the number of shares subject to such awards, to make any combination of awards to participants, to accelerate at any time the exercisability or vesting of any award, to impose any limitations and/or vesting conditions on each award and to determine the specific terms and conditions of each award, subject to the provisions of the 2023 Plan. Persons eligible to participate in the 2023 Plan are full or part-time officers, employees, non-employee directors and consultants as selected from time to time by our Compensation Committee in its discretion.

The 2023 Plan permits the granting of both options to purchase Series A common stock intended to qualify as incentive stock options under Section 422 of the Code and options that do not so qualify. The option exercise price of each option will be determined by our Compensation Committee but may not be less than 100% of the fair market value of our Series A common stock on the date of grant unless the option is granted (i) pursuant to a transaction described in, and in a manner consistent with, Section 424(a) of the Code or (ii) to individuals who are not subject to U.S. income tax. The term of each option will be fixed by our Compensation Committee and may not exceed ten years from the date of grant. Our Compensation Committee will determine at what time or times each option may be exercised.

Our Compensation Committee may award stock appreciation rights subject to such conditions and restrictions as it may determine. Stock appreciation rights entitle the recipient to shares of Series A common stock, or cash, equal to the value of the appreciation in our stock price over the exercise price. The exercise price of each stock appreciation right may not be less than 100% of the fair market value of our Series A common stock on the date of grant unless the stock appreciation right is granted (i) pursuant to a transaction described in, and in a manner consistent with, Section 424(a) of the Code or (ii) to individuals who are not subject to U.S. income tax. The term of each stock appreciation right will be fixed by our Compensation Committee and may not exceed ten years from the date of grant. Our Compensation Committee will determine at what time or times each stock appreciation right may be exercised.

Our Compensation Committee may award restricted shares of Series A common stock and restricted stock units to participants subject to such conditions and restrictions as it may determine. These conditions and restrictions may include the achievement of certain performance goals and/or continued employment with us through a specified vesting period. Our Compensation Committee may also grant shares of Series A common stock that are free from any restrictions under the 2023 Plan. Unrestricted stock may be granted to participants in recognition of past services or for other valid consideration and may be issued in lieu of cash compensation due to such participant.

Our Compensation Committee may grant dividend equivalent rights to participants that entitle the recipient to receive credits for dividends that would be paid if the recipient had held a specified number of shares of our Series A common stock. Our Compensation Committee may grant cash bonuses under the 2023 Plan to participants, subject to the achievement of certain performance goals.

The 2023 Plan provides that upon the effectiveness of a "sale event," as defined in the 2023 Plan, an acquirer or successor entity may assume, continue or substitute outstanding awards under the 2023 Plan. To the extent that awards granted under the 2023 Plan are not assumed or continued or substituted by the successor entity, upon the effective time of the sale event, such awards shall terminate. In such case, except as may be otherwise provided in the relevant award certificate, all awards with time-based vesting conditions or restrictions shall become fully vested and exercisable or nonforfeitable as of the effective time of the sale event, and all awards with conditions and restrictions relating to the attainment of performance goals may become vested and exercisable or nonforfeitable in connection with a sale event in the administrator's discretion or to the extent specified in the relevant award certificate. In the event of such termination, individuals holding options and stock appreciation rights (i) may be permitted to exercise such options and stock appreciation rights (to the extent exercisable) within a specified period of time prior to the sale event or (ii) we may make or provide for a payment, in cash or in kind, to participants holding vested and

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exercisable options and stock appreciation rights equal to the difference between the per share consideration payable to stockholders in the sale event and the exercise price of the options or stock appreciation rights. In addition, we may make or provide for a payment, in cash or in kind, to participants holding other vested awards.

Our Board may amend or discontinue the 2023 Plan and our Compensation Committee may amend or cancel outstanding awards for purposes of satisfying changes in law or any other lawful purpose but no such action may adversely affect rights under an award without the holder's consent. Certain amendments to the 2023 Plan require the approval of our stockholders. The administrator of the 2023 Plan is specifically authorized to exercise its discretion to reduce the exercise price of outstanding stock options and stock appreciation rights or effect the repricing of such awards through cancellation and re-grants without stockholder consent. No awards may be granted under the 2023 Plan after the date that is ten years from the effective date of the 2023 Plan.

#### 2023 Employee Stock Purchase Plan
The 2023 Employee Stock Purchase Plan, as amended and restated, or the ESPP, was adopted by our Board in June 2023, approved by our stockholders in July 2023 and became effective in July 2023 in connection with our IPO. The ESPP is intended to qualify as an "employee stock purchase plan" within the meaning of Section 423 of the Code. The ESPP initially reserved and authorized the issuance of up to a total of 215,497 shares of Series A common stock to participating employees. The ESPP provides that the number of shares reserved and available for issuance will automatically increase each January 1 thereafter through January 1, 2033, by the least of (i) 215,497 shares of Series A common stock, (ii) 1% of the outstanding number of shares of our Series A common stock on the immediately preceding December 31 or (iii) such lesser number of shares of Series A common stock as determined by the administrator of the ESPP. The number of shares reserved under the ESPP is subject to adjustment in the event of a stock split, stock dividend or other change in our capitalization.

All employees are eligible to participate in the ESPP. However, any employee who owns 5% or more of the total combined voting power or value of all classes of stock will not be eligible to purchase shares under the ESPP.

We may make one or more offerings each year to our employees to purchase shares under the ESPP. Offerings will usually begin on each June 1 and December 1 and will continue for six-month periods, referred to as offering periods. Each eligible employee will be able to elect to participate in any offering by submitting an enrollment form at least 15 business days before the relevant offering date.

Each employee who is a participant in the ESPP will be able to purchase shares by authorizing payroll deductions of up to 15% of his or her eligible compensation during an offering period. Unless the participating employee has previously withdrawn from the offering, his or her accumulated payroll deductions will be used to purchase shares of Series A common stock on the last business day of the offering period at a price equal to 85% of the fair market value of the shares on the first business day or the last business day of the offering period, whichever is lower, provided that no more than 3,000 shares of Series A common stock may be purchased by any one employee during any offering period. Under applicable tax rules, an employee may purchase no more than $25,000 worth of shares of Series A common stock, valued at the start of the purchase period, under the ESPP in any calendar year.

The accumulated payroll deductions of any employee who is not a participant on the last day of an offering period will be refunded. An employee's rights under the ESPP will terminate upon voluntary withdrawal from the plan or when the employee ceases employment with us for any reason.

The ESPP may be terminated or amended by our Board at any time. An amendment that increases the number of shares of Series A common stock authorized under the ESPP and certain other amendments will require the approval of our stockholders.

#### Senior Executive Cash Incentive Bonus Plan
In June 2023, our Board adopted the Senior Executive Cash Incentive Bonus Plan, or the Bonus Plan. The Bonus Plan provides for cash bonus payments based upon company and individual performance targets

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established by our Compensation Committee. The payment targets are related to financial and operational measures or objectives with respect to our company, or one or more of the "Corporate Performance Goals" (as described below), as well as individual performance objectives.

Our Compensation Committee establishes the Corporate Performance Goals which may include the following: research, pre-clinical, non-clinical, developmental, publication, clinical or regulatory milestones; scientific or technological advances; research and development or manufacturing capabilities; cash flow (including, but not limited to, operating cash flow and free cash flow); revenue; corporate revenue; earnings before interest, taxes, depreciation and amortization; net income (loss) (either before or after interest, taxes, depreciation and/or amortization); changes in the market price of our Series A common stock; economic value-added; acquisitions, licenses, collaborations or strategic transactions; financing or other capital raising transactions; operating income (loss); return on capital, assets, equity, or investment; shareholder returns; return on sales; total shareholder return; gross or net profit levels; productivity; expense efficiency; margins; operating efficiency; satisfaction of, or other achievement metrics relating to, key third parties; working capital; earnings (loss) per share of our Series A common stock; bookings, new bookings or renewals; sales or market shares; number of prescriptions or prescribing physicians; coverage decisions; leadership development, employee retention, and recruiting and other human resources matters; operating income and/or net annual recurring revenue; or any other performance goal selected by the Compensation Committee, any of which may be measured in absolute terms, as compared to any incremental increase, in terms of growth, or as compared to results of a peer group, against the market as a whole, compared to applicable market indices and/or measured on a pre-tax or post-tax basis.

Each executive officer who is selected to participate in the Bonus Plan will have a target bonus opportunity set for each performance period and may also have a minimum and/or maximum bonus opportunity. The bonus formulas are adopted in each performance period by the Compensation Committee and communicated to each executive officer. The Corporate Performance Goals are measured at the end of each performance period after our financial reports have been published. If the Corporate Performance Goals and individual performance objectives are met, payments will be made as soon as practicable following the end of each performance period, but not later than 2 1∕2 months after the end of the fiscal year in which such performance period ends. Subject to the rights contained in any agreement between the executive officer and us, an executive officer shall be required to be employed by us on the bonus payment date to be eligible to receive a bonus payment.

#### Limitations on Liability and Indemnification
Our Charter contains provisions that limit the liability of our current and former directors for monetary damages to the fullest extent permitted by Delaware law. Delaware law provides that directors of a corporation will not be personally liable for monetary damages for any breach of fiduciary duties as directors, except liability for:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • any breach of the director's duty of loyalty to the corporation or its stockholders;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • any act or omission not in good faith or that involves intentional misconduct or a knowing violation of law;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • unlawful payments of dividends or unlawful stock repurchases or redemptions; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • any transaction from which the director derived an improper personal benefit.

Such limitation of liability does not apply to liabilities arising under federal securities laws and does not affect the availability of equitable remedies such as injunctive relief or rescission.

Our Charter authorizes us to indemnify our directors, officers, employees and other agents to the fullest extent permitted by Delaware law. Our Bylaws provide that we are required to indemnify our directors and officers to the fullest extent permitted by Delaware law and may indemnify our other employees and agents. Our Bylaws also provide that, on satisfaction of certain conditions, we will advance expenses incurred by a director or officer in advance of the final disposition of any action or proceeding, and permit us to secure insurance on behalf of any officer, director, employee, or other agent for any liability arising out of his or her actions in that capacity regardless of whether we would otherwise be permitted to indemnify him or her under the provisions of Delaware law. We have entered and expect to continue to enter into

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agreements to indemnify our directors, executive officers and other employees as determined by the Board. With certain exceptions, these agreements provide for indemnification for related expenses including attorneys' fees, judgments, fines and settlement amounts incurred by any of these individuals in any action or proceeding.

We believe that our Charter and Bylaws provisions and indemnification agreements are necessary to attract and retain qualified persons as directors and officers. We also maintain customary directors' and officers' liability insurance.

The limitation of liability and indemnification provisions in our Charter and Bylaws may discourage stockholders from bringing a lawsuit against our directors for breach of their fiduciary duty. They may also reduce the likelihood of derivative litigation against our directors and officers, even though an action, if successful, might benefit us and other stockholders. Further, a stockholder's investment may be adversely affected to the extent that we pay the costs of settlement and damage awards against directors and officers as required by these indemnification provisions.

Insofar as indemnification for liabilities arising under the Securities Act may be permitted for directors, executive officers, or persons controlling us, we have been informed that, in the opinion of the SEC, such indemnification is against public policy as expressed in the Securities Act and is therefore unenforceable.

#### Rule 10b5-1 Plans
We maintain a Rule 10b5-1 Policy, under which our directors, executive officers and employees may adopt written plans, known as Rule 10b5-1 plans, in which they will contract with a broker to buy or sell shares of our Series A common stock on a periodic basis. Under a Rule 10b5-1 plan, a broker executes trades under parameters established by the director or officer when entering into the plan, without further direction from them. The director or officer may amend a Rule 10b5-1 plan in some circumstances and may terminate a plan at any time. Our directors and executive officers may also buy or sell additional shares outside of a Rule 10b5-1 plan when they do not possess material nonpublic information, subject to compliance with the terms of our insider trading policy.

#### Insider Trading Arrangements and Policies
We have adopted insider trading policies and procedures governing the purchase, sale, and other dispositions of securities of Sagimet by directors, officers, and employees that we believe are reasonably designed to promote compliance with insider trading laws, rules and regulations, and applicable Nasdaq listing standards. Our insider trading policy states, among other things, that our directors, officers, and employees are prohibited from trading in such securities while in possession of material, nonpublic information. In addition, with regard to trading in our own securities, it is our policy to comply with the federal securities laws and the applicable exchange listing requirements.

#### Compensation Recovery Policy
Our Board has adopted a Compensation Recovery Policy, or the Clawback Policy, applicable to all officers subject to Section 16 of the Exchange Act. Under the Clawback Policy, we will pursue recoupment of any excess compensation, which was awarded to a covered officer based on financial statements of the Company where such statements are required to be restated. In addition to recoupment of any excess compensation, we will seek to recoup up to 100% of all incentive-based compensation in the case of (i) willful, knowing or intentional misconduct or a willful, knowing or intentional violation of any of our rules or applicable legal or regulatory requirements or (ii) fraud in the course of a covered employee's employment. The recovery period for recoupment of any compensation is up to three fiscal years preceding the date on which we determine we are required to prepare and file the restated financial statements. This policy has been adopted to comply with the final guidance under Section 954 of the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010.

#### Policies and Practices Regarding Grants of Equity Awards
Our Compensation Committee and Board generally make equity grants on regularly scheduled dates, which includes grants in February for executive officers and other employees and following our annual

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meetings of shareholders for non-employee directors. The Board or Compensation Committee may change any regularly scheduled grant date if the Board or Compensation Committee determines that making grants on such date would not be in the Company's best interest. Equity grants may also be made on other dates in connection with new hires, promotions or similar events. During 2025, our Compensation Committee did not take into account any material nonpublic information when determining the timing and terms of equity incentive awards and we did not time the disclosure of material nonpublic information for the purpose of affecting the value of such awards.

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#### CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS
There were no transactions with related persons to be reported in this proxy statement as defined in Item 404 of Regulation S-K in which:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • the amounts involved exceeded or will exceeds the lesser of $120,000 or 1% of our total assets at the year-end for the last two completed fiscal years; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; • any of our directors, executive officers or holders of more than 5% of our outstanding capital stock, or any immediate family member of, or person sharing the household with, any of these individuals or entities, had or will have a direct or indirect material interest.

#### Employment Arrangements
We have entered into employment agreements with certain of our named executive officers, and granted stock options to our named executive officers and certain of our directors, as more fully described in "Executive Compensation" and "Director Compensation."

#### Executive Officer and Director Compensation
Please see "Executive Compensation" and "Director Compensation" for information regarding the compensation of our directors and executive officers.

#### Indemnification Agreements
Our Charter contains provisions limiting the liability of directors and officers, and our Bylaws provide that we will indemnify each of our directors and officers to the fullest extent permitted under Delaware law. Our Charter and Bylaws also provide our Board with discretion to indemnify our employees and other agents when determined appropriate by the Board. In addition, we have entered into indemnification agreements with each of our directors and executive officers, which require us to indemnify them. For more information regarding these agreements, see "Executive Compensation — Limitations on Liability and Indemnification."

#### Policies and Procedures for Transactions with Related Persons
We have adopted a written policy that our executive officers, directors, nominees for election as a director, beneficial owners of more than 5% of any series of our Series A common stock and any members of the immediate family of any of the foregoing persons are not permitted to enter into a related person transaction with us without the approval or ratification of our Board or our Audit Committee. Any request for us to enter into a transaction with an executive officer, director, nominee for election as a director, beneficial owner of more than 5% of any series of our Series A common stock, or any member of the immediate family of any of the foregoing persons, in which the amount involved exceeds $120,000 (or, if less, 1% of the average of our total assets in a fiscal year) and such person would have a direct or indirect interest, must be presented to our Board or our Audit Committee for review, consideration and approval. In approving or rejecting any such proposal, our Board or our Audit Committee is to consider the material facts of the transaction, including whether the transaction is on terms no less favorable than terms generally available to an unaffiliated third party under the same or similar circumstances and the extent of the related person's interest in the transaction.

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#### EQUITY COMPENSATION PLAN INFORMATION
The following table presents aggregate summary information as of December 31, 2025, regarding the Series A common stock that may be issued upon the exercise of options and rights under all of our existing equity compensation plans:

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| | | | |
|:---|:---|:---|:---|
| | **Column (A)**  | **Column (B)**  | **Column (C)**  |
| **Plan Category**  | **Number of Securities to be <br> Issued Upon Exercise of <br> Outstanding Options, <br> Restricted Stock <br> Units and Other Rights**  | **Weighted Average <br> Exercise Price of <br> Outstanding <br> Options**  | **Number of Securities <br> Remaining Available <br> for Future Issuance <br> Under Equity <br> Compensation <br> Plans (Excluding <br> Securities Reflected <br> in Column A)**  |
|  Equity Compensation Plans Approved by Stockholders<sup>(1)</sup>  | 5718433(2) | $6.46 | 2040076(3) |
|  Equity Compensation Plans Not Approved by <br> Stockholders<sup>(4)</sup>  | 833970(5) | $4.13 | 361217 |
| Total | 6552403 | $6.12 | 2401293 |

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(1) These plans consist of the 2017 Plan, 2023 Plan and our ESPP.

(2) As of December 31, 2025, (i) 1,395,328 shares remained available for future issuance under our 2023 Plan and (ii) 644,748 shares remained available for future issuance under our ESPP. No shares remained available for future issuance under the 2017 Plan as of December 31, 2025. However, the 2017 Plan continue to govern outstanding equity awards granted thereunder. Our 2023 Plan has an evergreen provision that allows for an annual increase in the number of shares available for issuance under the 2023 Plan to be added on the first day of January in an amount equal to the lesser of (i) 4% of the outstanding number of shares of our Series A common stock on the immediately preceding December 31 or (ii) such number of shares as determined by our Compensation Committee in each case subject to adjustment in the event of a stock split, stock dividend or other change in our capitalization. Our ESPP has an evergreen provision that allows for an annual increase in the number of shares available for issuance under the ESPP to be added on the first day of each January through January 1, 2033, by the lesser of (i) 215,497 shares of our Series A common stock, (ii) 1% of the outstanding number of shares of Series A common stock on the immediately preceding December 31, or (iii) such number of shares of Series A common stock as determined by the administrator of the ESPP. The number of shares reserved under the ESPP is subject to adjustment in the event of a stock split, stock dividend or other change in our capitalization.

(3) This amount excludes (i) 1,278,164 shares of Series A common stock that became issuable under the 2023 Plan and (ii) 215,497 that became issuable under the ESPP on January 1, 2026, pursuant to the evergreen provisions of the 2023 Plan and ESPP.

(4) We have established a pool of 1,300,000 shares of Series A common stock from which grants can be issued with Compensation Committee approval but without stockholder approval as inducement for new employees to accept employment offers from the Company under Nasdaq Listing Rule 5635(c)(4). Inducement grants to new employees are determined on a case-by-case basis. Other than inducement grants, we expect that all equity awards will be made under stockholder-approved plans.

(5) Reflects grants of stock options to purchase 833,970 shares of common stock that were "inducement grants" as defined under Nasdaq Listing Rule 5635(c)(4). The terms and conditions of each inducement grant are subject to the terms and conditions of Forms of Award Agreements filed with our 2025 Annual Report.

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#### SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
The following table sets forth certain information regarding the beneficial ownership of Series A common stock as of April 17, 2026, except to the extent indicated otherwise in the footnotes, by (a) each person known by us to be the beneficial owner of more than 5% of the outstanding shares of Series A common stock, (b) each named executive officer identified in the "Summary Compensation Table" above, (c) each director and nominee for director, and (d) all executive officers and directors as a group.

We have determined beneficial ownership in accordance with the rules and regulations of the SEC, and the information is not necessarily indicative of beneficial ownership for any other purpose. Except as indicated by the footnotes below, we believe, based on information furnished to us, that the persons and entities named in the table below have sole voting and sole investment power with respect to all shares that they beneficially own, subject to applicable community property laws.

The following table excludes our non-voting Series B common stock. Entities associated with Baker Brothers Life Sciences, L.P., or Baker Brothers, hold all 567,494 outstanding shares of Series B common stock. Baker Brothers has the right to convert each share of Series B common stock into one share of Series A common stock at such its election, provided that as a result of such conversion, Baker Brothers would not beneficially own in excess of 4.99% of any series of our securities registered under the Exchange Act, except as expressly provided for in Charter.

The percentage of Series A common stock outstanding is based on 32,017,613 shares of Series A common stock outstanding as of April 17, 2026.

In computing the number of shares beneficially owned by a person and the percentage ownership of such person, we deemed to be outstanding all shares subject to options held by the person that are currently exercisable, or exercisable within 60 days of April 17, 2026. However, except as described above, we did not deem such shares outstanding for the purpose of computing the percentage ownership of any other person.

Unless otherwise indicated, the address for each beneficial owner listed in the table below is c/o Sagimet Biosciences Inc., 155 Bovet Road, Suite 303, San Mateo, California 94402.

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| | | |
|:---|:---|:---|
| | **SHARES OF SERIES A COMMON STOCK <br> BENEFICIALLY OWNED**  | **SHARES OF SERIES A COMMON STOCK <br> BENEFICIALLY OWNED**  |
| **NAME OF BENEFICIAL OWNER**  | **NUMBER OF SHARES**  | **PERCENTAGE**  |
| **Directors and Named Executive Officers:** |  |  |
| David Happel<sup>(1)</sup> | 1357932 | 4.1% |
| Eduardo Bruno Martins, M.D., D.Phil.<sup>(2)</sup> | 316572 | 1.0% |
| Elizabeth Rozek, Esq.<sup>(3)</sup> | 315045 | 1.0% |
| George Kemble, Ph.D.<sup>(4)</sup> | 997436 | 3.0% |
| Elizabeth Grammer, Esq.<sup>(5)</sup> | 133242 | \* |
| Paul Hoelscher<sup>(6)</sup> | 94261 | \* |
| Jennifer Jarrett<sup>(7)</sup> | 96870 | \* |
| Beth Seidenberg, M.D.<sup>(8)</sup> | 267090 | \* |
| Anne Phillips, M.D.<sup>(9)</sup> | 96870 | \* |
| Timothy P. Walbert<sup>(10)</sup> | 96461 | \* |
| All directors and executive officers as a group (11 persons)<sup>(11)</sup> | 4109040 | 11.5% |

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\*

Less than 1%

(1) Consists of 278,166 shares of Series A common stock and 1,079,766 shares of Series A common stock subject to options exercisable within 60 days of April 17, 2026.

(2) Consists of 33,011 shares of Series A common stock and 283,561 shares of Series A common stock subject to options exercisable within 60 days of April 17, 2026.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

(3) Consists of 69,894 shares of Series A common stock and 245,151 shares of Series A common stock subject to options exercisable within 60 days of April 17, 2026.

(4) Consists of 5,630 shares of Series A common stock and 991,806 shares of Series A common stock subject to options exercisable within 60 days of April 17, 2026.

(5) Consists of 133,242 shares of Series A common stock subject to options exercisable within 60 days of April 17, 2026.

(6) Consists of 94,261 shares of Series A common stock subject to options exercisable within 60 days of April 17, 2026.

(7) Consists of 96,870 shares of Series A common stock subject to options exercisable within 60 days of April 17, 2026.

(8) Consists of (i) 84,768 shares of Series A common stock held directly by Beth Seidenberg, M.D., (ii) 46,875 shares of Series A common stock held by the Seidenberg/Vogel Revocable Trust UA 3/6/03, of which Dr. Seidenberg serves as a trustee and (iii) 135,447 shares of Series A common stock subject to options exercisable within 60 days of April 17, 2026.

(9) Consists of 96,870 shares of Series A common stock subject to options exercisable within 60 days of April 17, 2026.

(10) Consists of 2,200 shares of Series A common stock and 94,261 shares of Series A common stock subject to options exercisable within 60 days of April 17, 2026.

(11) Consists of (i) 523,482 shares of Series A common stock beneficially owned by our current executive officers and directors and (ii) 3,585,558 shares subject to options exercisable within 60 days of April 17, 2026.

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#### ITEMS TO BE VOTED ON

#### PROPOSAL 1: ELECTION OF CLASS III DIRECTORS FOR A THREE-YEAR TERM EXPIRING IN 2029
At the Annual Meeting, our stockholders will vote on the election of four Class III director nominees named in this Proxy Statement as directors, each to serve until our 2029 Annual Meeting and until their respective successors are elected and qualified. Our Board has unanimously nominated Jennifer Jarrett, Anne Phillips, M.D., David Happel and George Kemble, Ph.D. for election to our Board at the Annual Meeting.

Each of the nominees has agreed to be named and to serve, and we expect each nominee to be able to serve if elected. If any nominee is unable to serve, the Nominating and Corporate Governance Committee will recommend to our Board a replacement nominee. The Board may then designate the other nominee to stand for election. If you voted for the unavailable nominee, your vote will be cast for his or her replacement.

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|:---|:---|
| OUR BOARD UNANIMOUSLY RECOMMENDS STOCKHOLDERS VOTE **FOR** THE ELECTION OF JENNIFER JARRETT, ANNE PHILLIPS, M.D., DAVID HAPPEL AND GEORGE KEMBLE, PH.D.  | **✓**  |

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#### PROPOSAL 2: RATIFICATION OF APPOINTMENT OF KPMG LLP AS OUR INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR 2026
The Audit Committee of the Board has appointed and engaged KPMG to serve as our independent registered public accounting firm to audit the financial statements of the Company for the 2026 fiscal year, and to perform audit-related services. KPMG has served as our independent registered public accounting firm since August 2025.

Stockholders are hereby asked to ratify the Audit Committee's appointment of KPMG as our independent registered public accounting firm for the 2026 fiscal year.

The Audit Committee is solely responsible for selecting our independent auditors. Although stockholder ratification of the appointment of KPMG to serve as our independent registered public accounting firm is not required by law or our organizational documents, the Board has determined that it is desirable to seek stockholder ratification as a matter of good corporate governance in view of the critical role played by independent registered public accounting firms in maintaining the integrity of financial controls and reporting. If the stockholders do not ratify the appointment of KPMG, the Audit Committee will reconsider its selection and whether to engage an alternative independent registered public accounting firm.

Representatives of KPMG are expected to virtually attend the Annual Meeting where they will be available to respond to appropriate questions and, if they desire, to make a statement.

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|:---|:---|
| THE BOARD UNANIMOUSLY RECOMMENDS A VOTE **FOR** THE RATIFICATION OF KPMG LLP AS INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR THE COMPANY FOR THE FISCAL YEAR ENDING DECEMBER 31, 2026.  | **✓**  |

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#### OTHER INFORMATION

#### OTHER MATTERS
The Annual Meeting is called for the purposes set forth in the Notice. Our Board does not know of any other matters to be considered by the stockholders at the Annual Meeting, other than the matters described in the Notice. However, the enclosed proxy confers discretionary authority on the persons named in the proxy card with respect to matters that may properly come before the Annual Meeting and that are not known to our Board at the date this Proxy Statement was printed. It is the intention of the persons named in the proxy card to vote in accordance with their best judgment on any such matter.

#### REQUIREMENTS FOR SUBMISSION OF STOCKHOLDER PROPOSALS FOR NEXT YEAR'S ANNUAL MEETING
Stockholders intending to present a proposal to be considered for inclusion in the proxy statement for our Annual Meeting must submit a proposal that is received at our principal executive offices no later than December 22, 2026, which is the 120th day prior to the first anniversary we made available this Proxy Statement to our stockholders for the Annual Meeting. Proposals must be sent via registered, certified, or express mail (or other means that allows the stockholder to determine when the proposal was received by our Corporate Secretary) to our Corporate Secretary at Sagimet Biosciences Inc., 155 Bovet Road, Suite 303, San Mateo, California 94402. Proposals must contain the information required under our Bylaws, a copy of which is available upon request to our Corporate Secretary, and also must comply with the SEC's regulations regarding the inclusion of stockholder proposals in Company-sponsored proxy materials.

Stockholders intending to present a proposal or nominate a director for election at our 2027 Annual Meeting of Stockholders, or 2027 Annual Meeting, without having the proposal or nomination included in our Proxy Statement must comply with the requirements set forth in our Bylaws. Our Bylaws require, among other things, that the Corporate Secretary of the Company receive the proposal or nomination no earlier than the close of business on the 120th day, and no later than the close of business on the 90th day, prior to the first anniversary of the preceding year's annual meeting. Accordingly, for our 2027 Annual Meeting, our Corporate Secretary must receive the proposal or nomination no earlier than February 12, 2027 and no later than the close of business on March 15, 2027. However, if we change the date of the Annual Meeting by more than 30 days before or 60 days after the anniversary of this year's Annual Meeting, stockholder proposals must be received no later than the close of business on the later of the 90th day prior to the scheduled date of the meeting or the tenth day following the day on which public notice of the meeting was first made. Proposals must contain the information required under our Bylaws, a copy of which is available upon request to our Corporate Secretary. If the stockholder does not meet the applicable deadlines or comply with the requirements of SEC Rule 14a-4, we may exercise discretionary voting authority under proxies we solicit to vote, in accordance with our best judgment, on any such proposal.

In addition, to comply with the universal proxy rules, stockholders intending to solicit proxies in support of director nominees other than our nominees must provide notice that sets forth the information required by Rule 14a-19 under the Exchange Act in the timeline provided under our Bylaws.

#### STOCKHOLDER COMMUNICATIONS TO THE BOARD
Stockholders and other interested parties may communicate with the Board by writing to the Corporate Secretary, Sagimet Biosciences Inc., 155 Bovet Road, Suite 303, San Mateo, California 94402. Communications intended for a specific director or directors should be addressed to their attention to the Corporate Secretary at the address provided above. Communications received from stockholders are forwarded directly to Board members as part of the materials mailed in advance of the next scheduled Board meeting following receipt of the communications. The Board has authorized the Corporate Secretary, in his or her discretion, to forward communications on a more expedited basis if circumstances warrant or to exclude a communication if it is illegal, unduly hostile or threatening, or similarly inappropriate. Advertisements, solicitations for periodical or other subscriptions, and other similar communications generally will not be forwarded to the directors.

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#### AVAILABILITY OF MATERIALS
Our 2025 Annual Report, including the financial statements and financial statement schedules, has been filed with the SEC and provides additional information about us, which is incorporated by reference herein. It is available on the internet at www.sagimet.com and is available in paper form (other than exhibits thereto) by first class mail or other equally prompt means to beneficial owners of our Series A common stock, without charge, upon written request to: Chief Legal & Administrative Officer, Sagimet Biosciences Inc., 155 Bovet Road, Suite 303, San Mateo, California 94402. In addition, it is available to beneficial and record holders of our Series A common stock at www.astproxyportal.com/ast/27458.

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PROXY VOTING INSTRUCTIONS Please detach along perforated line and mail in the envelope provided IF you are not voting via telephone or the Internet. 20430000000000001000 7 061226 COMPANY NUMBER ACCOUNT NUMBER ANNUAL MEETING OF STOCKHOLDERS OF SAGIMET BIOSCIENCES INC. June 12, 2026 NOTICE OF INTERNET AVAILABILITY OF PROXY MATERIALS: The Notice of Meeting, Annual Report on Form 10-K, proxy statement and proxy card are available at www.astproxyportal.com/ast/27458 INTERNET - Access www.voteproxy.com and follow the on-screen instructions or scan the QR code with your smartphone. Have your proxy card available when you access the web page. TELEPHONE - Call toll-free 1-800-PROXIES (1-800-776-9437) in the United States or +1-201-299-4446 worldwide from any touch-tone telephone and follow the instructions. Have your proxy card available when you call. Vote online/phone until 11:59 p.m. Eastern Time the day before the meeting. MAIL - Sign, date and mail your proxy card in the envelope provided as soon as possible. GO GREEN - e-Consent makes it easy to go paperless. With e-Consent, you can quickly access your proxy materials, statements and other eligible documents online, while reducing costs, clutter and paper waste. Enroll today via equiniti.com/us/ast-access to enjoy online access. Signature of Stockholder Date: Signature of Stockholder Date: Note: Please sign exactly as your name or names appear on this Proxy. When shares are held jointly, each holder should sign. When signing as executor, administrator, attorney, trustee or guardian, please give full title as such. If the signer is a corporation, please sign full corporate name by duly authorized officer, giving full title as such. If signer is a partnership, please sign in partnership name by authorized person. To change the address on your account, please check the box at right and indicate your new address in the address space above. Please note that changes to the registered name(s) on the account may not be submitted via this method. INSTRUCTIONS: To withhold authority to vote for any individual nominee(s), mark "FOR ALL EXCEPT" and fill in the circle next to each nominee you wish to withhold, as shown here: THE BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR ALL NOMINEES" IN THE ELECTION OF CLASS III DIRECTORS AND "FOR" PROPOSAL 2. PLEASE SIGN, DATE AND RETURN PROMPTLY IN THE ENCLOSED ENVELOPE. PLEASE MARK YOUR VOTE IN BLUE OR BLACK INK AS SHOWN HERE x 1. The election of Class III directors for a three year term expiring in 2029: O Jennifer Jarrett O Anne Phillips, M.D. O David Happel O George Kemble, Ph.D. 2. The ratification of the appointment of Deloitte & Touche LLP as the independent registered public accounting firm for the fiscal year ending December 31, 2026. In their discretion, the proxies are authorized to vote upon such other business as may properly come before the Annual Meeting. This proxy when properly executed will be voted as directed herein by the undersigned shareholder. If no direction is made, this proxy will be voted FOR ALL NOMINEES in Proposal 1 and FOR Proposal 2. FOR FOR ALL NOMINEES WITHHOLD AUTHORITY FOR ALL NOMINEES FOR ALL EXCEPT (See instructions below) NOMINEES: MARK "X" HERE IF YOU PLAN TO ATTEND THE MEETING. AGAINST ABSTAIN

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0------------------ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ----------------14475SAGIMET BIOSCIENCES INC.155 Bovet Road, Suite 303San Mateo, California 94402THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORSThe undersigned stockholder hereby appoints David Happel and Elizabeth Rozek asproxies, each with full power of substitution, to represent and vote as designated on thereverse side of this ballot, all the shares of Series A Common Stock of Sagimet BiosciencesInc. held of record and entitled to vote by the undersigned as of April 17, 2026, at the AnnualMeeting of Stockholders to be held on Friday, June 12, 2026, at 9:30 a.m. Pacific Time, orat any adjournment or postponement thereof, as well as to vote upon such other businessas may properly come before the Annual Meeting of Stockholders.(Continued and to be signed on the reverse side)1.1

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