# EDGAR Filing Document

**Accession Number:** 0001447028
**File Stem:** 0001171843-25-005076
**Filing Date:** 2025-8
**Character Count:** 27171
**Document Hash:** a175d651aeb036ad47a672a4822e5a9d
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001171843-25-005076.hdr.sgml**: 20250806

**ACCESSION NUMBER**: 0001171843-25-005076

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 14

**CONFORMED PERIOD OF REPORT**: 20250804

**ITEM INFORMATION**: Results of Operations and Financial Condition

**ITEM INFORMATION**: Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers

**ITEM INFORMATION**: Other Events

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20250806

**DATE AS OF CHANGE**: 20250806

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Arbutus Biopharma Corp
- **CENTRAL INDEX KEY:** 0001447028
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 980597776
- **STATE OF INCORPORATION:** A1
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-34949
- **FILM NUMBER:** 251187463

**BUSINESS ADDRESS:**
- **STREET 1:** 701 VETERANS CIRCLE
- **CITY:** WARMINSTER
- **STATE:** PA
- **ZIP:** 18974
- **BUSINESS PHONE:** 604-419-3200

**MAIL ADDRESS:**
- **STREET 1:** 701 VETERANS CIRCLE
- **CITY:** WARMINSTER
- **STATE:** PA
- **ZIP:** 18974

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** TEKMIRA PHARMACEUTICALS Corp
- **DATE OF NAME CHANGE:** 20110607

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** TEKMIRA PHARMACEUTICALS CORP
- **DATE OF NAME CHANGE:** 20081003

?xml version='1.0' encoding='ASCII'? Form 8-K

### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION

### Washington, D.C. 20549
_________________

### FORM 8-K
_________________

#### CURRENT REPORT

#### Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

#### Date of Report (Date of earliest event reported): August 4, 2025
_______________________________

#### Arbutus Biopharma Corporation
(Exact name of registrant as specified in its charter)

_______________________________

---

| | | |
|:---|:---|:---|
| **British Columbia, Canada** | **001-34949** | **98-0597776** |
| (State or Other Jurisdiction of Incorporation) | (Commission File Number) | (I.R.S. Employer Identification No.) |

---

#### 701 Veterans Circle

#### Warminster, Pennsylvania 18974
(Address of Principal Executive Offices) (Zip Code)

(267) 469-0914

(Registrant's telephone number, including area code)

(Former name or former address, if changed since last report)

_______________________________

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

---

| | | |
|:---|:---|:---|
| Title of each class | Trading Symbol(s) | Name of each exchange on which registered |
| Common Shares, without par value | ABUS | The Nasdaq Stock Market LLC |

---

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

**Item 2.02. Results of Operations and Financial Condition.**

On August 6, 2025, Arbutus Biopharma Corporation (the "Company") issued a press release announcing its financial results for the second quarter ended June 30, 2025 and certain other information. A copy of the press release is furnished herewith as Exhibit 99.1 and is incorporated by reference herein.

**Item 5.02. Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.**

***Resignation of Director***

On August 4, 2025, Anuj Hasija notified the Company of his decision to resign from the Board of Directors of the Company (the "Board") and all committees thereof, effective immediately. The resignation of Mr. Hasija is not due to any disagreement with the Company on any matter relating to the Company's operations, policies or practices.

***Appointment of Director***

On August 4, 2025, the Board appointed Dr. Roger Sawhney to the Board, to serve until the Company's 2026 annual general meeting of shareholders or until his successor is duly appointed and qualified, or until his earlier death, resignation or removal. Dr. Sawhney was also appointed as a member of the Board's Audit Committee and Corporate Governance and Nominating Committee.

The Company expects to grant an initial option to acquire 157,600 common shares of the Company to Dr. Sawhney, and for the cash compensation for Dr. Sawhney to be consistent with the cash compensation generally provided to the Company's non-employee directors. The option grant is expected to vest over a 3-year period with one-third vesting each year on the annual anniversary date of the grant, subject to Dr. Sawhney's continued service on the Board. The option will be exercisable for 10 years from the date of the grant, at a price equal to the closing price of the Company's common shares on the Nasdaq Stock Market on the date of the grant. The option grant will also be subject to the terms and conditions of the Arbutus Biopharma Corporation 2016 Omnibus Share and Incentive Plan, as supplemented and amended, which was filed as Exhibit 10.1 to the Company's Current Report on Form 8-K, filed with the Securities and Exchange Commission (the "SEC") on May 28, 2024. Historical director compensation arrangements are described under "*Director Compensation*" in the Company's Definitive Proxy Statement on Schedule 14A filed with the SEC on April 4, 2025.

The Company also entered into an indemnity agreement with Dr. Sawhney in connection with his appointment to the Board. The indemnity agreement is in substantially the same form as the indemnity agreement for all other directors of the Company, which was filed as Exhibit 10.1 to the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2024, filed with the SEC on March 27, 2025. No arrangement or understanding exists between Dr. Sawhney and any other person pursuant to which Dr. Sawhney was appointed as a director, and there are no transactions in which Dr. Sawhney has an interest which would require disclosure under Item 404(a) of Regulation S-K of the Securities Act of 1933, as amended.

On August 6, 2025, the Company issued a press release announcing the transitions described under this Item 5.02. A copy of the press release is filed herewith as Exhibit 99.1 and is incorporated by reference herein.

**Item 8.01. Other Events.**

On August 6, 2025, the Company issued a press release with updates to its ongoing patent infringement litigations against Moderna and Pfizer/BioNTech. In the U.S. litigation against Moderna, Inc. and a Moderna affiliate (collectively, "Moderna"), the U.S. District Court for the District of Delaware issued a new scheduling order in June 2025 providing for the summary judgment phase of the case to begin in July 2025 and for a jury trial to be held in March 2026. Additionally, in July 2025, the case was reassigned to a different judge in the same court. In the five international lawsuits filed against Moderna and/or its affiliates in March 2025, the first major hearings are expected in the first half of calendar year 2026. In the litigation against Pfizer Inc. and BioNTech SE, the Company noted that the U.S. District Court for the District of New Jersey that is presiding over the case has not provided guidance for the timing of its ruling in the claim construction hearing that occurred in December 2024, but such ruling could potentially come in 2025.

**Item 9.01. Financial Statements and Exhibits.**

**(d) Exhibits.**

---

| | |
|:---|:---|
| **<u>Exhibit Number</u>** | **<u>Description</u>** |
| [99.1](exh_991.htm) | [Press release dated August 6, 2025](exh_991.htm) |
| 104 | Cover page interactive data file (formatted as inline XBRL). |

---

#### SIGNATURE
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

---

| | | |
|:---|:---|:---|
|  | **Arbutus Biopharma Corporation** | **Arbutus Biopharma Corporation** |
| Date: August 6, 2025 | By: | <u>/s/ Tuan Nguyen&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u> |
|  |  | Tuan Nguyen |
|  |  | Chief Financial Officer |

---

## Exhibit 99.1

**EXHIBIT 99.1**

**Arbutus Reports Second Quarter 2025 Financial Results and Provides Corporate Update**

**Q2 total revenue of $10.7M includes previously-deferred revenue following reacquisition of Greater China rights to imdusiran**

**Dr. Roger Sawhney joins the Arbutus Board of Directors following resignation of Anuj Hasija**

**Dr. Harry Janssen joins the Arbutus Scientific Advisory Board**

**Strong financial position with cash, cash equivalents and marketable securities of $98.1M**

WARMINSTER, Pa., Aug. 06, 2025 (GLOBE NEWSWIRE) -- Arbutus Biopharma Corporation (Nasdaq: ABUS) ("Arbutus" or the "Company"), a clinical-stage biopharmaceutical company focused on infectious disease, today reported second quarter 2025 financial results and provided a corporate update.

"We delivered a strong quarter, marked by positive quarterly earnings resulting from the conclusion of our Greater China partnership with Qilu," said Lindsay Androski, President and CEO of Arbutus. "Once again holding global rights for imdusiran, and launching a late-stage clinically focused Scientific Advisory Board, were two important steps taken this quarter in our quest to drive long-term value through our chronic hepatitis B virus (cHBV) programs."

"I am excited to announce that Dr. Harry Janssen of Erasmus MC in Rotterdam has joined our Scientific Advisory Board, bringing his unparalleled knowledge and experience in late-stage clinical trials in cHBV," Ms. Androski continued. "Today, the Company also congratulates Anuj Hasija on his appointment as Vice President, Global Commercial Strategy for Type 1 Diabetes at Vertex. Anuj has stepped down from the Arbutus Board in order to focus exclusively on this new role, and on behalf of the Company and the entire Board, I thank Anuj for his service. We are also excited to welcome Dr. Roger Sawhney as the newest member of our Board. Dr. Sawhney has enjoyed a distinguished career spanning senior executive roles in biotech, pharma and investing, and also brings extensive public company board experience."

**<u>LNP Litigation</u>**

* Arbutus continues to consult closely with and support our exclusive licensee, Genevant Sciences, to protect and defend Arbutus's intellectual property, which is the subject of on-going lawsuits against Moderna and Pfizer/BioNTech. The Company, together with Genevant, is seeking fair compensation for Moderna's and Pfizer/BioNTech's use of Arbutus's patented LNP technology that was developed with great effort and at a great expense, and without which Moderna's and Pfizer/BioNTech's COVID-19 vaccines would not have been successful.

* In the Moderna U.S. litigation, fact discovery has been completed, and expert discovery is concluding. The summary judgment phase of the case began in July 2025 and a jury trial is scheduled to be held in March 2026. Additionally, in July 2025, the case was reassigned to a different judge in the same court. In March 2025, the Company, alongside Genevant Sciences, filed five international lawsuits against Moderna and its affiliates seeking to enforce patents protecting the Company's patented LNP technology across 30 countries. The first major hearings in the international lawsuits are expected in the first half of calendar year 2026.

* The claim construction hearing for the lawsuit against Pfizer/BioNTech occurred in December 2024. The court has not provided guidance for the timing of its ruling in the claim construction hearing, which could potentially come in 2025.

**<u>Corporate Updates</u>**

* In June 2025, the Company and Qilu Pharmaceutical mutually agreed to conclude the strategic partnership for the development, manufacturing, and commercialization of imdusiran in Greater China. The Company now once again holds global rights for its lead compound, imdusiran.

* Dr. Harry L.A. Janssen, MD, PhD, joined the Company's Scientific Advisory Board effective August 1, 2025, increasing the membership to six global experts in cHBV treatment. Dr. Janssen is a Professor of Hepatology and the Chair of the Department of Gastroenterology and Hepatology at Erasmus MC, Rotterdam, The Netherlands.

* Effective August 4, 2025, Anuj Hasija resigned from the Company's Board of Directors due to his transition to a full-time executive role that precludes his participation on the Arbutus and other boards of directors.

* Filling the vacancy on our Board of Directors, Dr. Roger Sawhney, MD, joined the Board effective August 4, 2025. Dr. Sawhney is a seasoned executive and board member with extensive experience across biotechnology, pharmaceuticals, healthcare technology, and investment sectors. He holds an MD from Harvard Medical School and a BA in Economics from Stanford University.

**<u>Financial Results</u>**

**Cash, Cash Equivalents and Investments** 

As of June 30, 2025, the Company had cash, cash equivalents and investments in marketable securities of $98.1 million compared to $122.6 million as of December 31, 2024. During the six months ended June 30, 2025, the Company used $29.1 million in operating activities, which included one-time payments related to our restructuring efforts. This was partially offset by $3.1 million of proceeds from the exercise of employee stock options.

**Revenue** 

Total revenue was $10.7 million for the quarter ended June 30, 2025, compared to $1.7 million for the same period in 2024. The increase of $9.0 million was primarily due to the recognition of all previously-deferred revenue as a result of the conclusion of the Company's strategic partnership with Qilu Pharmaceutical, partially offset by a decrease in license royalty revenues due to a decline in Alnylam's sales of ONPATTRO.

**Operating Expenses** 

Research and development expenses were $5.5 million for the quarter ended June 30, 2025 compared to $15.6 million for the same period in 2024. The decrease of $10.1 million was due primarily to cost savings from the Company's decision in August 2024 to streamline the organization to focus its efforts on advancing the clinical development of imdusiran and AB-101, which included ceasing all discovery efforts, discontinuing its IM-PROVE III clinical trial and reducing the Company's workforce.

General and administrative expenses were $3.3 million for the quarter ended June 30, 2025, compared to $7.5 million for the same period in 2024. This decrease was due primarily to cost cutting efforts by the Company, which drove reductions in litigation-related legal fees and employee compensation-related expenses.

Restructuring costs in the quarter ended June 30, 2025 were $0.2 million, and all remaining restructuring-related payments are expected to be made in the second half of 2025.

**Net Income/Loss**

For the quarter ended June 30, 2025, the Company's net income was $2.5 million, or income of $0.01 per basic and diluted common share, as compared to a net loss of $19.8 million, or a loss of $0.11 per basic and diluted common share, for the quarter ended June 30, 2024.

**Outstanding Shares** 

As of June 30, 2025, the Company had 191.6 million common shares issued and outstanding, as well as 15.2 million stock options and unvested restricted stock units outstanding.

---

| | | | | |
|:---|:---|:---|:---|:---|
| **UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF INCOME AND LOSS**<br>**(in thousands, except share and per share data)** | **UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF INCOME AND LOSS**<br>**(in thousands, except share and per share data)** | **UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF INCOME AND LOSS**<br>**(in thousands, except share and per share data)** | **UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF INCOME AND LOSS**<br>**(in thousands, except share and per share data)** | **UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF INCOME AND LOSS**<br>**(in thousands, except share and per share data)** |
|  | **Three Months Ended June 30,** | **Three Months Ended June 30,** | **Six Months Ended June 30,** | **Six Months Ended June 30,** |
|  | **2025** | **2024** | **2025** | **2024** |
| **Revenue** |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Collaborations and licenses | $10213 | $1155 | $11529 | $2094 |
| &nbsp;&nbsp;&nbsp;&nbsp;Non-cash royalty revenue | 526 | 571 | 974 | 1164 |
| **Total Revenue** | 10739 | 1726 | 12503 | 3258 |
| **Operating expenses** |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Research and development | 5498 | 15551 | 14457 | 30954 |
| &nbsp;&nbsp;&nbsp;&nbsp;General and administrative | 3328 | 7547 | 9160 | 12859 |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in fair value of contingent consideration | 260 | 211 | 559 | 391 |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring costs | 165 |  | 12538 |  |
| **Total operating expenses** | 9251 | 23309 | 36714 | 44204 |
| **Gain (loss) from operations** | 1488 | (21583) | (24211) | (40946) |
| **Other income** |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Interest income | 1042 | 1829 | 2239 | 3374 |
| &nbsp;&nbsp;&nbsp;&nbsp;Interest expense | (28) | (34) | (56) | (78) |
| &nbsp;&nbsp;&nbsp;&nbsp;Foreign exchange gain (loss) | 21 | (8) | 25 | (21) |
| **Total other income** | 1035 | 1787 | 2208 | 3275 |
| Income tax expense |  |  |  |  |
| **Net income (loss)** | $2523 | $(19796) | $(22003) | $(37671) |
| Net income (loss) per common share |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Basic | $0.01 | $(0.11) | $(0.12) | $(0.21) |
| &nbsp;&nbsp;&nbsp;&nbsp;Diluted | $0.01 | $(0.11) | $(0.12) | $(0.21) |
| Weighted average number of common shares |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Basic | 191551282 | 188041489 | 191130631 | 181842519 |
| &nbsp;&nbsp;&nbsp;&nbsp;Diluted | 192399733 | 188041489 | 191130631 | 181842519 |

---

---

| | | |
|:---|:---|:---|
| **UNAUDITED CONDENSED CONSOLIDATED BALANCE SHEETS**<br>**(in thousands)** | **UNAUDITED CONDENSED CONSOLIDATED BALANCE SHEETS**<br>**(in thousands)** | **UNAUDITED CONDENSED CONSOLIDATED BALANCE SHEETS**<br>**(in thousands)** |
|  | **June 30, 2025** | **December 31, 2024** |
| Cash, cash equivalents and marketable securities, current | $98088 | $122623 |
| Accounts receivable and other current assets | 5031 | 4693 |
| &nbsp;&nbsp;&nbsp;&nbsp;**Total current assets** | 103119 | 127316 |
| Property and equipment, net of accumulated depreciation and impairment | 148 | 3309 |
| Right of use asset |  | 1048 |
| Other non-current assets |  | 34 |
| &nbsp;&nbsp;&nbsp;&nbsp;**Total assets** | $103267 | $131707 |
| Accounts payable and accrued liabilities | $4508 | $7564 |
| Deferred license revenue, current |  | 7571 |
| Lease liability, current | 514 | 483 |
| &nbsp;&nbsp;&nbsp;&nbsp;**Total current liabilities** | 5022 | 15618 |
| Liability related to sale of future royalties | 3910 | 4829 |
| Deferred license revenue, non-current |  | 2863 |
| Contingent consideration | 10784 | 10225 |
| Lease liability, non-current | 575 | 806 |
| Total stockholders' equity | 82976 | 97366 |
| &nbsp;&nbsp;&nbsp;&nbsp;**Total liabilities and stockholders' equity** | $103267 | $131707 |

---

---

| | | |
|:---|:---|:---|
| **UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS**<br>**(in thousands)** | **UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS**<br>**(in thousands)** | **UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS**<br>**(in thousands)** |
|  | **Six Months Ended June 30,** | **Six Months Ended June 30,** |
|  | **2025** | **2024** |
| Net loss | $(22003) | $(37671) |
| Non-cash items | 5834 | 3973 |
| Change in deferred license revenue | (10434) | (757) |
| Other changes in working capital | (2537) | 656 |
| &nbsp;&nbsp;&nbsp;&nbsp;**Net cash used in operating activities** | (29140) | (33799) |
| &nbsp;&nbsp;&nbsp;&nbsp;**Net cash provided by investing activities** | 26960 | 21523 |
| Issuance of common shares pursuant to the Open Market Sale Agreement |  | 44124 |
| Cash provided by other financing activities | 3237 | 4676 |
| &nbsp;&nbsp;&nbsp;&nbsp;**Net cash provided by financing activities** | 3237 | 48800 |
| Effect of foreign exchange rate changes on cash and cash equivalents | 25 | (21) |
| &nbsp;&nbsp;&nbsp;&nbsp;**Increase in cash and cash equivalents** | 1082 | 36503 |
| Cash and cash equivalents, beginning of period | 36330 | 26285 |
| &nbsp;&nbsp;&nbsp;&nbsp;**Cash and cash equivalents, end of period** | 37412 | 62788 |
| Investments in marketable securities | 60676 | 85725 |
| &nbsp;&nbsp;&nbsp;&nbsp;**Cash, cash equivalents and marketable securities, end of period** | $98088 | $148513 |

---

**<u>About Imdusiran (AB-729)</u>**

Imdusiran is an RNAi therapeutic specifically designed to reduce all hepatitis B viral proteins and antigens including HBsAg, which is thought to be a key prerequisite to enable reawakening of a patient's immune system to control the virus. Imdusiran targets hepatocytes using Arbutus' novel covalently conjugated N-Acetylgalactosamine (GalNAc) delivery technology enabling subcutaneous delivery. To date, Arbutus has reported a total of eight patients with cHBV who have achieved a functional cure following treatment with imdusiran and NA therapy in combination with either IFN or low dose nivolumab plus an immunotherapeutic. Clinical data generated thus far has shown imdusiran to be generally safe and well-tolerated, while also providing meaningful reductions in HBsAg and hepatitis B virus DNA.

**<u>About HBV</u>**

Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV). HBV can cause chronic infection which leads to a higher risk of death from cirrhosis and liver cancer. cHBV infection represents a significant unmet medical need. The World Health Organization estimates that over 250 million people worldwide suffer from cHBV infection, while other estimates indicate that approximately 2 million people in the United States suffer from cHBV infection. Approximately 1.1 million people die every year from complications related to cHBV infection despite the availability of effective vaccines and current treatment options.

**<u>About Arbutus</u>**

Arbutus Biopharma Corporation (Nasdaq: ABUS) is a clinical-stage biopharmaceutical company focused on infectious disease. The company is currently developing imdusiran (AB-729) and an oral PD-L1 inhibitor (AB-101) for the treatment of cHBV infection. The Company is also consulting closely with and supporting its exclusive licensee, Genevant Sciences, to protect and defend its intellectual property, which is the subject of on-going lawsuits against Moderna and Pfizer/BioNTech for use of Arbutus's patented LNP technology in their COVID-19 vaccines. For more information, visit www.arbutusbio.com.

**<u>Forward-Looking Statements and Information</u>**

This press release contains forward-looking statements within the meaning of the Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, and forward-looking information within the meaning of Canadian securities laws (collectively, forward-looking statements). Forward-looking statements in this press release include statements about: the potential to lead to a functional cure for HBV; the potential for Arbutus' product candidates to achieve success in clinical trials; Arbutus' pipeline and development plans for its cHBV programs; and Arbutus' plans with respect to the ongoing patent litigation matters, and the expected timing thereof.

With respect to the forward-looking statements contained in this press release, Arbutus has made numerous assumptions regarding, among other things: the effectiveness and timeliness of clinical trials, and the usefulness of the data; the continued demand for Arbutus' assets; and the stability of economic and market conditions. While Arbutus considers these assumptions to be reasonable, these assumptions are inherently subject to significant business, economic, competitive, market and social uncertainties and contingencies. Additionally, there are known and unknown risk factors which could cause Arbutus' actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements contained herein. Known risk factors include, among others: ongoing and anticipated clinical trials may be more costly or take longer to complete than anticipated, and may never be initiated or completed, or may not generate results that warrant future development of the tested product candidate; Arbutus may elect to change its strategy regarding its product candidates and clinical development activities; Arbutus may not receive the necessary regulatory approvals for the clinical development of Arbutus' product candidates; uncertainties associated with litigation generally and patent litigation specifically; economic and market conditions may worsen; market shifts may require a change in strategic focus; Arbutus' workforce reduction and plans to reduce its net cash burn may not materially extend the cash runway and may create a distraction or uncertainty that may adversely affect its operating results, business, or investor perceptions; and risks related to the sufficiency of Arbutus' cash resources for its foreseeable and unforeseeable operating expenses and capital expenditures.

A more complete discussion of the risks and uncertainties facing Arbutus appears in Arbutus' Annual Report on Form 10-K, Arbutus' Quarterly Reports on Form 10-Q and Arbutus' continuous and periodic disclosure filings, which are available at www.sedar.com and at www.sec.gov. All forward-looking statements herein are qualified in their entirety by this cautionary statement, and Arbutus disclaims any obligation to revise or update any such forward-looking statements or to publicly announce the result of any revisions to any of the forward-looking statements contained herein to reflect future results, events or developments, except as required by law.

Arbutus Biopharma Corporation / ir@arbutusbio.com