# EDGAR Filing Document

**Accession Number:** 0001637890
**File Stem:** 0001193125-23-078009
**Filing Date:** 2023-3
**Character Count:** 964569
**Document Hash:** fbd70f5b249be799f14075f41def161f
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-23-078009.hdr.sgml**: 20230323

**ACCESSION NUMBER**: 0001193125-23-078009

**CONFORMED SUBMISSION TYPE**: 20-F

**PUBLIC DOCUMENT COUNT**: 184

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230323

**DATE AS OF CHANGE**: 20230323

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Celyad Oncology SA
- **CENTRAL INDEX KEY:** 0001637890
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** C9
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 20-F
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-37452
- **FILM NUMBER:** 23756962

**BUSINESS ADDRESS:**
- **STREET 1:** RUE EDOUARD BELIN 12
- **CITY:** MONT-SAINT-GUIBERT
- **STATE:** C9
- **ZIP:** 1435
- **BUSINESS PHONE:** 32 10 394 100

**MAIL ADDRESS:**
- **STREET 1:** RUE EDOUARD BELIN 12
- **CITY:** MONT-SAINT-GUIBERT
- **STATE:** C9
- **ZIP:** 1435

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** CELYAD S.A.
- **DATE OF NAME CHANGE:** 20150506

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** CARDIO3 BIOSCIENCES S.A.
- **DATE OF NAME CHANGE:** 20150326

?xml version="1.0" encoding="utf-8" ? 20-F

##### [**Table of Contents**](#toc)
UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 20-F

(Mark One)

☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934

OR

☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the fiscal year ended December 31, 2022

OR

☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from <u>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u> to <u>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u>

OR

☐ SHELL COMPANY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

Date of event requiring this shell company report

Commission file number 001-37452

CELYAD ONCOLOGY SA

(Exact name of Registrant as specified in its charter and translation of Registrant's name into English)

Belgium

(Jurisdiction of incorporation or organization)

Rue Edouard Belin 2

1435 Mont-Saint-Guibert, Belgium

(Address of principal executive offices)

Michel Lussier, permanent representative of Mel Management SRL

Interim Chief Executive Officer

Celyad Oncology SA

Rue Edouard Belin 2

1435 Mont-Saint-Guibert, Belgium

Tel: +32 10 394 100 Fax: +32 10 394 141

(Name, Telephone, E-mail and/or Facsimile number and Address of Company Contact Person)

Securities registered or to be registered pursuant to Section 12(b) of the Act.

---

| | | |
|:---|:---|:---|
| Title of each class | Trading<br>Symbol | Name of each exchange<br>on which registered |
| American Depositary Shares, each representing one ordinary share, no nominal value per share | CYAD | The Nasdaq Stock Market LLC |
| Ordinary shares, no nominal value per share\* |  | The Nasdaq Stock Market LLC\* |
| Title of each class | Trading<br>Symbol | Name of each exchange<br>on which registered |
| American Depositary Shares, each representing one ordinary share, no nominal value per share | CYAD | The Nasdaq Stock Market LLC |
| Ordinary shares, no nominal value per share\* |  | The Nasdaq Stock Market LLC\* |

---

\* Not for trading, but only in connection with the registration of the American Depositary Shares.

Securities registered or to be registered pursuant to Section 12(g) of the Act. None

Securities for which there is a reporting obligation pursuant to Section 15(d) of the Act. None

Indicate the number of outstanding shares of each of the issuer's classes of capital or common stock as of the close of the period covered by the Annual Report.

Ordinary shares, no nominal value per share: 22,593,956 as of December 31, 2022

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.&nbsp;&nbsp;&nbsp;&nbsp;☐ Yes&nbsp;&nbsp;&nbsp;&nbsp;☒ No

If this report is an annual or transition report, indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934.&nbsp;&nbsp;&nbsp;&nbsp;☐ Yes&nbsp;&nbsp;&nbsp;&nbsp;☒ No

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.&nbsp;&nbsp;&nbsp;&nbsp;☒ Yes&nbsp;&nbsp;&nbsp;&nbsp;☐ No

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).&nbsp;&nbsp;&nbsp;&nbsp;☒ Yes&nbsp;&nbsp;&nbsp;&nbsp;☐ No

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or an emerging growth company. See definition of "large accelerated filer," "accelerated filer," and "emerging growth company" in Rule 12b-2 of the Exchange Act. (Check one):

Large accelerated filer ☐ Accelerated filer ☐ Non-accelerated filer ☒ Emerging growth company ☐

If an emerging growth company that prepares its financial statements in accordance with U.S. GAAP, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards† provided pursuant to Section 13(a) of the Exchange Act. ☐

Indicate by check mark whether the registrant has filed a report on and attestation to its management's assessment of the effectiveness of its internal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its audit report. ☐

If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrant included in the filing reflect the correction of an error to previously issued financial statements. ☐

Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation received by any of the registrant's executive officers during the relevant recovery period pursuant to §240.10D-1(b). ☐

† The term "new or revised financial accounting standard" refers to any update issued by the Financial Accounting Standards Board to its Accounting Standards Codification after April 5, 2012.

Indicate by check mark which basis of accounting the registrant has used to prepare the financial statements included in this filing:

U.S. GAAP ☐ &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;International Financial Reporting Standards as issued Other ☐ <br> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;by the International Accounting Standards Board ☒

If "Other" has been checked in response to the previous question, indicate by check mark which financial statement item the registrant has elected to follow.&nbsp;&nbsp;&nbsp;&nbsp;☐ Item 17&nbsp;&nbsp;&nbsp;&nbsp;☐ Item 18

If this is an Annual Report, indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).&nbsp;&nbsp;&nbsp;&nbsp;☐ Yes&nbsp;&nbsp;&nbsp;&nbsp;☒ No

------

##### [**Table of Contents**](#toc)

#### **TABLE OF CONTENTS**

---

| | | |
|:---|:---|:---|
| | | **Page** |
|  **[SUMMARY OF THE MATERIAL RISKS ASSOCIATED WITH OUR BUSINESS](#txa418841_1)** | **[SUMMARY OF THE MATERIAL RISKS ASSOCIATED WITH OUR BUSINESS](#txa418841_1)** | **1** |
|  **[INTRODUCTION](#txa418841_2)** | **[INTRODUCTION](#txa418841_2)** | **2** |
|  **[SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS](#txa418841_3)** | **[SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS](#txa418841_3)** | **3** |
|  **[PART I](#txa418841_4)** | **[PART I](#txa418841_4)** | **5** |
|  **Item 1.** | **[Identity of Directors, Senior Management and Advisers](#txa418841_5)** | **5** |
|  **Item 2.** | **[Offer Statistics and Expected Timetable](#txa418841_6)** | **5** |
|  **Item 3.** | **[Key Information](#txa418841_7)** | **5** |
|  | [**A.** *\[Reserved\]*](#txa418841_8) | *5* |
|  | [**B.** *Capitalization and Indebtedness*](#txa418841_9) | *5* |
|  | [**C.** *Reasons for the Offer and Use of Proceeds*](#txa418841_10) | *5* |
|  | [**D.** *Risk Factors*](#txa418841_11) | *5* |
|  **Item 4.** | **[Information on the Company](#txa418841_12)** | **51** |
|  | [**A.** *History and Development of the Company*](#txa418841_13) | *51* |
|  | [**B.** *Business Overview*](#txa418841_14) | *51* |
|  | [**C.** *Organizational Structure.*](#txa418841_15) | *89* |
|  | [**D.** *Property, Plants and Equipment.*](#txa418841_16) | *89* |
|  **Item 4A.** | **[Unresolved Staff Comments.](#txa418841_17)** | **90** |
|  **Item 5.** | **[Operating and Financial Review and Prospects](#txa418841_18)** | **90** |
|  | [**A.** *Operating Results*](#txa418841_19) | *92* |
|  | [**B.** *Liquidity and Capital Resources*](#txa418841_20) | *101* |
|  | [**C.** *Research and Development*](#txa418841_21) | *106* |
|  | [**D.** *Trend Information*](#txa418841_22) | *106* |
|  | [**E.** *Critical Accounting Estimates*](#txa418841_23) | *106* |
|  | [**F.** *Safe Harbor.*](#txa418841_24) | *106* |
|  **Item 6.** | **[Directors, Senior Management and Employees](#txa418841_25)** | **106** |
|  | [**A.** *Directors and Senior Management.*](#txa418841_26) | *106* |
|  | [**B.** *Compensation*](#txa418841_27) | *111* |
|  | [**C.** *Board Practices*](#txa418841_28) | *119* |
|  | [**D.** *Employees*](#txa418841_29) | *121* |
|  | [**E.** *Share Ownership*](#txa418841_30) | *121* |
|  **Item 7.** | **[Major Shareholders and Related Party Transactions](#txa418841_31)** | **121** |
|  | [**A.** *Major shareholders*](#txa418841_32) | *121* |
|  | [**B.** *Related Party Transactions*](#txa418841_33) | *123* |
|  | [**C.** *Interest of Experts and Counsel*](#txa418841_34) | *126* |
|  **Item 8.** | **[Financial Information](#txa418841_35)** | **126** |
|  | [**A.** *Consolidated Statements and Other Financial Information Consolidated Financial Statements*](#txa418841_36) | *126* |
|  | [**B.** *Significant Changes*](#txa418841_37) | *126* |
|  **Item 9.** | **[The Offer and Listing](#txa418841_38)** | **127** |
|  | [**A.** *Offer and Listing Details*](#txa418841_39) | *127* |
|  | [**B.** *Plan of Distribution*](#txa418841_40) | *127* |
|  | [**C.** *Markets.*](#txa418841_41) | *127* |
|  | [**D.** *Selling Shareholders*](#txa418841_42) | *127* |
|  | [**E.** *Dilution*](#txa418841_43) | *127* |
|  | [**F.** *Expenses of the Issue*](#txa418841_44) | *127* |
|  **Item 10.** | **[Additional Information](#txa418841_45)** | **127** |
|  | [**A.** *Share Capital*](#txa418841_46) | *127* |
|  | [**B.** *Memorandum and Articles of Association*](#txa418841_47) | *127* |

---

i

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##### [**Table of Contents**](#toc)

---

| | | |
|:---|:---|:---|
|  | [**C.** *Material Contracts*](#txa418841_48) | *127* |
|  | [**D.** *Exchange Controls*](#txa418841_49) | *128* |
|  | [**E.** *Taxation*](#txa418841_50) | *128* |
|  | [**F.** *Dividends and Paying Agents*](#txa418841_51) | *138* |
|  | [**G.** *Statement by Experts*](#txa418841_52) | *138* |
|  | [**H.** *Documents on Display*](#txa418841_53) | *138* |
|  | [**I.** *Subsidiary Information*](#txa418841_54) | *138* |
|  **Item 11.** | **[Quantitative and Qualitative Disclosures About Market Risk](#txa418841_55)** | **138** |
|  **Item 12.** | **[Description of Securities Other than Equity Securities](#txa418841_56)** | **140** |
|  | [**A.** *Debt Securities*](#txa418841_57) | *140* |
|  | [**B.** *Warrants and Rights*](#txa418841_58) | *140* |
|  | [**C.** *Other Securities*](#txa418841_59) | *140* |
|  | [**D.** *American Depositary Shares*](#txa418841_60) | *140* |
|  **[PART II](#txa418841_61)** | **[PART II](#txa418841_61)** | **142** |
|  **Item 13.** | **[Defaults, Dividend Arrearages And Delinquencies](#txa418841_62)** | **142** |
|  **Item 14.** | **[Material Modifications to the Rights of Security Holders and Use of Proceeds](#txa418841_63)** | **142** |
|  **Item 15.** | **[CONTROLS AND PROCEDURES](#txa418841_64)** | **142** |
|  **Item 16.** | **[Reserved](#txa418841_65)** | **143** |
|  **Item 16A.** | **[Audit Committee Financial Expert](#txa418841_66)** | **143** |
|  **Item 16B.** | **[Code of Ethics](#txa418841_67)** | **143** |
|  **Item 16C.** | **[Principal Accountant Fees and Services](#txa418841_68)** | **143** |
|  **Item 16D.** | **[Exemptions from the Listing Standards for Audit Committees](#txa418841_69)** | **144** |
|  **Item 16E.** | **[Purchases of Equity Securities by the Issuer and Affiliated Purchasers](#txa418841_70)** | **145** |
|  **Item 16F.** | **[Change in Registrant's Certifying Accountant](#txa418841_71)** | **145** |
|  **Item 16G.** | **[Corporate Governance](#txa418841_72)** | **145** |
|  **Item 16H.** | **[Mine Safety Disclosure](#txa418841_73)** | **146** |
|  **Item 16I.** | **[Disclosure Regarding Foreign Jurisdictions that Prevent Inspections](#txa418841_74)** | **146** |
|  **[PART III](#txa418841_75)** | **[PART III](#txa418841_75)** | **147** |
|  **Item 17.** | **[Financial Statements](#txa418841_76)** | **147** |
|  **Item 18.** | **[FINANCIAL STATEMENTS](#txa418841_77)** | **147** |
|  **Item 19.** | **[Exhibits](#txa418841_78)** | **147** |
|  **[Note 1: The Company](#txa418841_79)** | **[Note 1: The Company](#txa418841_79)** | **F-10** |
|  **[Note 2: General information and Statement of Compliance](#txa418841_80)** | **[Note 2: General information and Statement of Compliance](#txa418841_80)** | **F-10** |
|  **[Note 3: Accounting Principles](#txa418841_81)** | **[Note 3: Accounting Principles](#txa418841_81)** | **F-12** |
|  ***[Foreign currency translation](#txa418841_82)*** | ***[Foreign currency translation](#txa418841_82)*** | **F-12** |
|  ***[Revenue](#txa418841_83)*** | ***[Revenue](#txa418841_83)*** | **F-13** |
|  ***[Other income](#txa418841_84)*** | ***[Other income](#txa418841_84)*** | **F-14** |
|  ***[Intangible assets](#txa418841_85)*** | ***[Intangible assets](#txa418841_85)*** | **F-15** |
|  ***[Property, plant and equipment](#txa418841_86)*** | ***[Property, plant and equipment](#txa418841_86)*** | **F-17** |
|  ***[Leases](#txa418841_87)*** | ***[Leases](#txa418841_87)*** | **F-18** |
|  ***[Impairment of non-financial assets](#txa418841_88)*** | ***[Impairment of non-financial assets](#txa418841_88)*** | **F-19** |
|  ***[Cash and cash equivalents](#txa418841_89)*** | ***[Cash and cash equivalents](#txa418841_89)*** | **F-19** |
|  ***[Financial assets](#txa418841_90)*** | ***[Financial assets](#txa418841_90)*** | **F-19** |
|  ***[Financial liabilities](#txa418841_91)*** | ***[Financial liabilities](#txa418841_91)*** | **F-20** |
|  ***[Provisions](#txa418841_92)*** | ***[Provisions](#txa418841_92)*** | **F-21** |
|  ***[Income taxes](#txa418841_93)*** | ***[Income taxes](#txa418841_93)*** | **F-23** |
|  ***[Earnings (loss) per share](#txa418841_94)*** | ***[Earnings (loss) per share](#txa418841_94)*** | **F-24** |
|  ***[Equity](#txa418841_95)*** | ***[Equity](#txa418841_95)*** | **F-24** |
|  **[Assets held for sale](#txa418841_96)** | **[Assets held for sale](#txa418841_96)** | **F-24** |
|  **[Note 4: Risk Management](#txa418841_97)** | **[Note 4: Risk Management](#txa418841_97)** | **F-25** |
|  **[Note 5: Critical accounting estimates and judgments](#txa418841_98)** | **[Note 5: Critical accounting estimates and judgments](#txa418841_98)** | **F-26** |
|  **[Note 6: Operating segment information](#txa418841_99)** | **[Note 6: Operating segment information](#txa418841_99)** | **F-28** |
|  **[Note 7: Intangible assets](#txa418841_100)** | **[Note 7: Intangible assets](#txa418841_100)** | **F-30** |
|  **[Note 8: Property, plant and equipment](#txa418841_101)** | **[Note 8: Property, plant and equipment](#txa418841_101)** | **F-33** |
|  **[Note 9: Non-current trade receivables and other non-current assets](#txa418841_102)** | **[Note 9: Non-current trade receivables and other non-current assets](#txa418841_102)** | **F-34** |
|  **[Note 10: Inventories and Work in Progress](#txa418841_103)** | **[Note 10: Inventories and Work in Progress](#txa418841_103)** | **F-35** |
|  **[Note 11: Trade, other receivables and other assets](#txa418841_104)** | **[Note 11: Trade, other receivables and other assets](#txa418841_104)** | **F-35** |

---

ii

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##### [**Table of Contents**](#toc)

---

| | |
|:---|:---|
|  **[Note 12: Short-term investment](#txa418841_105)** | **F-36** |
|  **[Note 13: Cash and cash equivalents](#txa418841_106)** | **F-36** |
|  **[Note 14: Investment in Subsidiaries](#txa418841_107)** | **F-36** |
|  **[Note 15: Share Capital](#txa418841_108)** | **F-37** |
|  **[Note 16: Share-based payments](#txa418841_109)** | **F-41** |
|  **[Note 17: Post-employment Benefits](#txa418841_110)** | **F-45** |
|  **[Note 18: Other reserves](#txa418841_111)** | **F-47** |
|  **[Note 19: Recoverable Cash advances](#txa418841_112)** | **F-48** |
|  **[Note 20: Due dates of the Financial Liabilities](#txa418841_113)** | **F-50** |
|  **[Note 21: Other non-current liabilities](#txa418841_114)** | **F-50** |
|  **[Note 22: Trade payables and other current liabilities](#txa418841_115)** | **F-51** |
|  **[Note 23: Financial instruments](#txa418841_116)** | **F-51** |
|  **[Note 24: Changes in liabilities arising from financial activities](#txa418841_117)** | **F-55** |
|  **[Note 25: Revenues](#txa418841_118)** | **F-56** |
|  **[Note 26: Operating expenses](#txa418841_119)** | **F-56** |
|  **[Note 27: Employee Benefit Expenses](#txa418841_120)** | **F-58** |
|  **[Note 28: Other Income and Other Expenses](#txa418841_121)** | **F-59** |
|  **[Note 29: Change in fair value of contingent consideration and impairment of oncology intangible assets](#txa418841_122)** | **F-61** |
|  **[Note 30: Leases](#txa418841_123)** | **F-62** |
|  **[Note 31: Financial income and expenses](#txa418841_124)** | **F-64** |
|  **[Note 32: Income Tax](#txa418841_125)** | **F-64** |
|  **[Note 33: Deferred taxes](#txa418841_126)** | **F-65** |
|  **[Note 34: Commitments](#txa418841_127)** | **F-66** |
|  **[Note 35: Relationships with related Parties](#txa418841_128)** | **F-69** |
|  **[Note 36: Loss per share](#txa418841_129)** | **F-70** |
|  **[Note 37: Events after the close of the fiscal Year](#txa418841_130)** | **F-70** |
|  **[EXHIBIT INDEX](#txa418841_131)** | **EX-1** |

---

iii

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##### [**Table of Contents**](#toc)

#### SUMMARY OF THE MATERIAL RISKS ASSOCIATED WITH OUR BUSINESS
Our business is subject to numerous material and other risks and uncertainties, including those described in Item 3.D. "Risk Factors" in this Report. The principal risks and uncertainties affecting our business include the following:

• We, or licensees of our intellectual property, may conduct clinical programs in the future. Initial success in our future clinical trials may not be indicative of results obtained when these trials are completed. Furthermore, success in early clinical trials may not be indicative of results obtained in later trials.

• We have obtained and will seek to obtain significant funding from the Walloon Region. The terms of the agreements signed with the Region may hamper our ability to partner part or all of our future products.

• We rely and will continue to rely on collaborative partners regarding the development of any future research programs and future product candidates.

• We will rely on third parties to conduct, supervise and monitor any future clinical trials. If these third parties do not successfully carry out their contractual duties or meet expected deadlines, we may not be able to obtain regulatory approval for or commercialize any product candidates and our business could be substantially harmed.

• Our patents and other intellectual property rights portfolio are relatively young and may not adequately protect our research programs and product candidates, which may impede our ability to compete effectively.

• We may infringe on the patents or intellectual property rights of others and may face patent litigation, which may be costly and time consuming.

• We depend on intellectual property licensed from third parties and termination of any of these licenses could result in the loss of significant rights, which would harm our business.

• We could be unsuccessful in obtaining or maintaining adequate patent protection for one or more of our technologies or product candidates.

• We are highly dependent on our key personnel, and if we are not successful in attracting, motivating and retaining highly qualified personnel, we may not be able to successfully implement our business strategy.

• We have incurred net losses in each period since our inception and anticipate that we will continue to incur net losses in the future.

• We may need substantial additional funding, which may not be available on acceptable terms when needed, if at all.

• Our net losses and significant cash used in operating activities have raised doubt regarding our ability continue as a going concern.

• Raising additional capital may cause dilution to our existing shareholders, restrict our operations or require us to relinquish rights to any product candidates or technologies.

• If securities or industry analysts do not publish research or publish inaccurate research or unfavorable research about our business, the price of the ordinary shares and the ADSs and trading volume could decline.

• The market price of the shares could be negatively impacted by actual or anticipated sales of substantial numbers of ordinary shares or ADSs.

• A public market for our shares may not be sustained.

• The market price of the shares may fluctuate widely in response to various factors.

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##### [**Table of Contents**](#toc)

#### INTRODUCTION
Unless otherwise indicated, "Celyad," "Celyad Oncology", "the Company," "our company," "the Group," "we," "us" and "our" refer to Celyad Oncology SA and its consolidated subsidiaries.

We own various trademark registrations and applications, and unregistered trademarks and service marks, including "CELYAD", "C-CATH<sub>ez</sub>" and our corporate logo. All other trademarks or trade names referred to in this Annual Report on Form 20-F are the property of their respective owners. Trade names, trademarks and service marks of other companies appearing in this Annual Report on Form 20-F are the property of their respective holders. Solely for convenience, the trademarks and trade names in this Annual Report on Form 20-F may be referred to without the <sup>®</sup> and <sup>™</sup> symbols, but such references should not be construed as any indicator that their respective owners will not assert, to the fullest extent under applicable law, their rights thereto. We do not intend to use or display other companies' trademarks and trade names to imply a relationship with, or endorsement or sponsorship of us, any other companies.

Our audited consolidated financial statements have been prepared in accordance with International Financial Reporting Standards, or IFRS, as issued by the International Accounting Standards Board, or IASB. Our consolidated financial statements are presented in euros. All references in this Annual Report on Form 20-F to "$," "US$," "U.S.$," "U.S. dollars," "dollars" and "USD" mean U.S. dollars and all references to "€", "EUR", and "euros" mean euros, unless otherwise noted. Throughout this Annual Report on Form 20-F, references to ADSs mean ADSs or ordinary shares represented by ADSs, as the case may be.

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##### [**Table of Contents**](#toc)

#### SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS
This Annual Report on Form 20-F, or Annual Report, contains forward-looking statements. All statements other than present and historical facts and conditions contained in this Annual Report, including statements regarding our future results of operations and financial positions, business strategy, plans and our objectives for future operations, are forward-looking statements. When used in this Annual Report, the words "anticipate," "believe," "can," "could," "estimate," "expect," "intend," "is designed to," "may," "might," "plan," "potential," "predict," "objective," "should," or the negative of these and similar expressions identify forward-looking statements. Forward-looking statements include, but are not limited to, statements about:

• Our reliance on the success of licensing our current technologies and patent portfolio or any product candidates;

• The implementation of our business model and strategic plans for our business and intellectual property portfolio;

• The scope of protection we are able to establish and maintain for intellectual property rights covering any product candidates and current or future technology;

• Our ability to operate our business without infringing, misappropriating or otherwise violating the intellectual property rights and proprietary technology of third parties;

• Cost associated with enforcing or defending intellectual property infringement, misappropriation or violation; product liability; and other claims;

• Regulatory development in the United States, the European Union ("EU"), and other jurisdictions;

• The commercialization of any product candidates that we or a party to whom we license our intellectual property develop, if approved;

• The pricing and reimbursement of any product candidates that we or a party to whom we license our intellectual property develop, if approved;

• Estimates of our expenses, future revenues, capital requirements and our needs for additional financing;

• Our ability to obtain additional financing, if necessary, on attractive terms or at all;

• The potential benefits of strategic collaboration agreements and our ability to enter into strategic arrangements;

• Our ability to maintain and establish collaborations or obtain additional grant funding;

• The rate and degree of market acceptance of any product candidates, if approved;

• Our financial performance;

• Developments relating to our competitors and our industry, including competing therapies;

• Our ability to effectively manage our anticipated growth;

• Our ability to attract and retain qualified employees and key personnel;

• Our ability to build our finance infrastructure, improve our accounting systems and controls and remedy the material weakness identified in our internal control over financial reporting;

• Statements regarding future revenue, hiring plans, expenses, capital expenditures, capital requirements and share performance;

• Our expectations regarding our passive foreign investment company (PFIC) status; and

• Other risks and uncertainties, including those listed in the section of this annual report titled "Item 3.D.—Risk Factors."

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You should refer to the section of this Annual Report titled "Item 3.D.—Risk Factors" for a discussion of important factors that may cause our actual results to differ materially from those expressed or implied by our forward-looking statements. As a result of these factors, we cannot assure you that the forward-looking statements in this Annual Report will prove to be accurate. Furthermore, if our forward-looking statements prove to be inaccurate, the inaccuracy may be material. In light of the significant uncertainties in these forward-looking statements, you should not regard these statements as a representation or warranty by us or any other person that we will achieve our objectives and plans in any specified time frame or at all. We undertake no obligation to publicly update any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.

You should read this Annual Report and the documents that we reference in this Annual Report with the understanding that our actual future results may be materially different from what we expect. We qualify all of our forward-looking statements by these cautionary statements.

This Annual Report contains market data and industry forecasts that were obtained from industry publications. These data involve a number of assumptions and limitations, and you are cautioned not to give undue weight to such estimates. While we believe the market position, market opportunity and market size information included in this Annual Report is generally reliable, such information is inherently imprecise.

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#### PART I

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| **ITEM 1.** | **IDENTITY OF DIRECTORS, SENIOR MANAGEMENT AND ADVISERS**  |

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Not applicable.

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| **ITEM 2.** | **OFFER STATISTICS AND EXPECTED TIMETABLE**  |

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Not applicable.

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| **ITEM 3.** | **KEY INFORMATION**  |

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A. [Reserved]

Not applicable.

B. Capitalization and Indebtedness

Not applicable.

C. Reasons for the Offer and Use of Proceeds

Not applicable.

D. Risk Factors

*Our business faces significant risks. You should carefully consider all of the information set forth in this Annual Report and in our other filings with the U.S. Securities and Exchange Commission, or the SEC, including the following risk factors which we face, and which are faced by our industry. Our business, financial condition or results of operations could be materially adversely affected by any of these risks. This Annual Report also contains forward-looking statements that involve risks and uncertainties. Our results could materially differ from those anticipated in these forward-looking statements, as a result of certain factors including the risks described below and elsewhere in this report and our other SEC filings. See "Special Note Regarding Forward-Looking Statements" above.* 

#### Risks Related to Product Development, Regulatory Approval and Commercialization
***We are heavily dependent on licensing our patent portfolio and product candidates and the regulatory approval of those and any future product candidates that we or a third party to whom we license our intellectual property develop, and subsequent commercial success of such product candidates, both of which may never occur.***

We are a biotechnology company with no products approved by regulatory authorities or available for commercial sale. We may be unable to develop or commercialize a product, product candidate or research program, or may cease some of our operations, which may have a material adverse effect on our business.

We have generated limited revenue to date and do not expect to generate any revenue from product sales for the foreseeable future. As a result, our future success is currently dependent upon the licensing and regulatory approval and commercial success of any current product candidates and future CAR T-cell therapy product candidates that we or a third party to whom we license our intellectual property develop. Our ability to generate revenues in the near term will depend on our ability to obtain regulatory approval and successfully commercialize any future product candidates or license our patent portfolio and product candidates. We, or our licensing partners, may experience delays in obtaining regulatory approval in the United States for such clinical candidates, if they are approved at all, and the price of our ordinary shares and/or ADSs may be negatively impacted. Even if we, or our licensing partners, receive regulatory approval, the timing of the commercial launch of any product candidates in the United States is dependent upon a number of factors, including, but not limited to, hiring sales and marketing personnel, pricing and reimbursement timelines, the production of sufficient quantities of commercial drug product and implementation of marketing and distribution infrastructure.

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In addition, we have incurred and expect to continue to incur significant expenses as we continue to strengthen our research efforts. The success of any product candidates, if approved, and revenue from commercial sales, will depend on several factors, including:

• Execution of an effective sales and marketing strategy for the commercialization of any product candidates;

• Acceptance by patients, the medical community and third-party payors;

• Our success in educating physicians and patients about the benefits, administration and use of any product candidates;

• The incidence and prevalence of the indications for which any product candidates are approved in those markets in which the candidate(s) are approved;

• The incidence and severity of side effects, if any, experienced by patients treated with any product candidates;

• The availability, perceived advantages, cost, safety and efficacy of alternative treatments, including potential alternate treatments that may currently be available or in development or may later be available or in development or approved by regulatory authorities;

• Maintaining compliance with regulatory requirements, including, good laboratory practices ("GLPs"); and

• Obtaining and maintaining patent, trademark and trade secret protection and regulatory exclusivity and otherwise protecting our rights in our intellectual property portfolio.

We may also fail in our efforts to develop and commercialize product candidates. If this were to occur our development costs may increase and our ability to generate revenue or profits, or to raise additional capital, could be impaired.

The achievement of milestones (such as those related to research and development, scientific, clinical, regulatory and business) will trigger payment obligations towards Celdara, Dartmouth and Horizon Discovery, which will negatively impact our profitability.

***We do not currently have any ongoing clinical programs. If we initiate any clinical development programs, initial success in any future clinical trials, by us or our licensing partners, may not be indicative of results obtained when these trials are completed. Furthermore, success in early clinical trials may not be indicative of results obtained in later trials.***

Trial designs and results from previous or ongoing trials are not necessarily predictive of future clinical trial results, and initial or interim results may not continue or be confirmed upon completion of a trial. Any positive data from early trials may not continue or occur for future patients in any future clinical trials we or our licensing partners may undertake, and results may not be repeated or observed in ongoing or future trials involving any product candidates.

In December 2020, we made the strategic decision to discontinue the development of our first-generation autologous NKG2D CAR T candidate CYAD-01 for the treatment of relapsed / refractory acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) based on clinical futility analysis of the data from the completed Phase 1 THINK trial and data from the Phase 1 DEPLETHINK trial which did not achieve the necessary internal clinical activity threshold set for the program to move into Phase 2 clinical development. We instead focused our clinical development efforts instead on our two other NKG2D-based CAR T-cell assets, CYAD-02 and CYAD-101.

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In April 2021, enrollment into the alloSHRINK study was discontinued, based on results from the dose-escalation cohorts and expansion segment, which allowed us to define the best treatment scheme for CYAD-101 to be used in the KEYNOTE-B79 study. In August 2022, we announced that we would seek partnerships to further continue the development of our last autologous candidate CYAD-02, following encouraging results from the dose-escalation cohorts shared in December 2021, in order to focus on allogeneic candidates. Recruitment in the KEYNOTE-B79 trial was initiated in December 2021. In February 2022, we announced our decision to voluntarily pause CYAD-101-002 trial to investigate reports of two fatalities that presented with similar pulmonary findings and evaluate any similar events in additional patients treated on study. On March 1, 2022, we were informed via-email communication from the FDA that the CYAD-101-002 trial had been placed on clinical hold due to insufficient information to assess risk to study subjects.

In June 2022, we submitted our complete response to the Clinical Hold to the FDA stating our intent to amend the eligibility criteria to exclude patients who have bilateral lung metastases and patients who have received treatment with epidermal growth factor receptor (EGFR) targeting monoclonal antibodies within the previous 9 months prior to trial recruitment. In July 2022, based on that complete response, we received notification that the FDA lifted the Clinical Hold on the trial. In October 2022, we made the decision to discontinue the development of CYAD-101 based on a strategic, financial and medical review, taking into account the costs associated with the pursuit of the program and the delays to reach key medical milestones following the resolution of the previous Clinical Hold.

In November 2020, we initiated the dose-escalation Phase 1 IMMUNICY-1 trial evaluating CYAD-211. On December 21, 2022, based on available data from 6 cohorts which did not achieve the necessary internal clinical activity threshold set for the program to move into Phase 2 clinical development, the Company announced that, based on a strategic and financial review, the development of CYAD-211 would be discontinued.

There is a high failure rate for drugs and biologics proceeding through clinical trials. A number of companies in the pharmaceutical and biotechnology industries have suffered significant setbacks in later stage clinical trials even after achieving promising results in earlier stage clinical trials. Data obtained from preclinical and clinical activities are subject to varying interpretations, which may delay, limit or prevent regulatory approval. In addition, regulatory delays or rejections may be encountered as a result of many factors, including changes in regulatory policy during the period of product development.

***In previous clinical programs involving T cell-based immunotherapies, some patients experienced serious adverse events. Any future product candidates we or our licensing partners develop may demonstrate a similar effect or have other properties that could halt their clinical development, prevent their regulatory approval, limit their commercial potential, or result in significant negative consequences.***

In previous and ongoing clinical trials involving CAR T-cell products by other companies or academic researchers, many patients experienced side effects such as neurotoxicity and CRS, which have in some cases resulted in clinical holds in ongoing clinical trials of CAR T product candidates. There have been life threatening events related to severe neurotoxicity and CRS, requiring intense medical intervention such as intubation or pressor support, and in several cases, resulted in death. Severe neurotoxicity is a condition that is currently defined clinically by cerebral edema, confusion, drowsiness, speech impairment, tremors, seizures, or other central nervous system side effects, when such side effects are serious enough to lead to intensive care. In some cases, severe neurotoxicity was thought to be associated with the use of certain lymphodepletion preconditioning regimens used prior to the administration of the CAR T-cell products. CRS is a condition that is currently defined clinically by certain symptoms related to the release of cytokines, which can include fever, chills, low blood pressure, when such side effects are serious enough to lead to intensive care with mechanical ventilation or significant vasopressor support. The exact cause or causes of CRS and severe neurotoxicity in connection with treatment of CAR T-cell products and product candidates is not fully understood at this time. In addition, patients have experienced other adverse events in these studies, such as a reduction in the number of blood cells (in the form of neutropenia, thrombocytopenia, anemia or other cytopenias), febrile neutropenia, chemical laboratory abnormalities (including elevated liver enzymes), and renal failure.

Undesirable side effects caused by any of our product candidates or other T cell-based immunotherapy product candidates, could cause us, our licensing partners, or regulatory authorities to interrupt, delay or halt clinical trials and could result in a more restrictive label or the delay or denial of regulatory approval by the FDA or other comparable foreign regulatory authorities. For example, on February 28, 2022, we announced our decision to voluntarily pause our Phase 1b KEYNOTE-B79 trial evaluating CYAD-101 administered concurrently with FOLFOX chemotherapy followed by MSD's anti-PD-1 therapy, KEYTRUDA<sup>®</sup> (pembrolizumab) in patients with refractory metastatic colorectal cancer following reports of two fatalities that presented with similar pulmonary findings. We investigated

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these reports and evaluated if there were any similar events in additional patients treated on study. Subsequently, on March 1, 2022, we were informed via e-mail communication from the FDA that the KEYNOTE-B79 trial has been placed on clinical hold due to insufficient information to assess risk to study subjects. The FDA lifted this clinical hold in July 2022 following our revision of the eligibility criteria for KEYNOTE-B79. We discontinued our development of CYAD-101 in October 2022 based on strategic considerations, including the delay to reaching milestones following the resolution of this clinical hold. No new safety concerns contributed to our decision to discontinue CYAD-101. Results of any of our, or our licensing partner's future trials could reveal a high and unacceptable severity and prevalence of side effects or unexpected characteristics in product candidates. Treatment-related side effects could also affect patient recruitment or the ability of enrolled patients to complete future trials or result in potential product liability claims. In addition, these side effects may not be appropriately recognized or managed by the treating medical staff, as toxicities resulting from T cell-based immunotherapies are not normally encountered in the general patient population and by medical personnel. If we develop future product candidates, we expect to have to train medical personnel regarding any T cell-based immunotherapy product candidates to understand their side effects for both our planned clinical trials and upon any commercialization of any T cell-based immunotherapy product candidates. Inadequate training in recognizing or managing the potential side effects of T cell-based immunotherapy product candidates could result in patient deaths. Any of these occurrences could have a material adverse effect on our business, financial condition and prospects.

***We, or any future licensing partners, may encounter substantial delays in future clinical trials or may fail to demonstrate safety and efficacy to the satisfaction of applicable regulatory authorities.***

Before obtaining regulatory approval or marketing authorization from regulatory authorities for the sale of any product candidates, if at all, we, or our licensing partners, must conduct extensive clinical trials to demonstrate the safety and efficacy of the product candidates in humans. Clinical testing is expensive, time-consuming and uncertain as to outcome. We cannot guarantee that any clinical trials will be conducted as planned or completed on schedule, if at all. A failure of one or more clinical trials can occur at any stage of testing. Events that may prevent successful or timely completion of clinical development include:

• Delays in raising, or inability to raise, sufficient capital to fund the planned clinical trials;

• Delays in reaching a consensus with regulatory agencies on trial design;

• Identifying, recruiting and training suitable clinical investigators;

• Delays in reaching agreement on acceptable terms with prospective clinical research organizations, or CROs, and clinical trial sites;

• Delays in obtaining required Investigational Review Board, or IRB, or ethics committee approval at each clinical trial site, or institutional biosafety committee, or IBC, approval, if applicable;

• Delays in recruiting suitable patients to participate in our clinical trials;

• Delays due to changing standard of care for the diseases we, or our licensing partners, are studying;

• Adding new clinical trial sites;

• Imposition of a clinical hold by regulatory agencies, including after an inspection of clinical trial operations or trial sites;

• Failure by CROs, other third parties, our licensing partners or us to adhere to clinical trial requirements;

• Catastrophic loss of product candidates due to shipping delays or delays in customs in connection with delivery to foreign countries for use in clinical trials;

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• Failure to perform in accordance with the FDA's GCPs or applicable regulatory guidelines in other countries;

• Delays in the testing, validation, manufacturing and delivery of product candidates to the clinical sites;

• Delays in having patients complete participation in a trial or return for post-treatment follow-up;

• Clinical trial sites or patients dropping out of a trial;

• Occurrence of serious adverse events associated with the drug product candidate that are viewed to outweigh its potential benefits;

• Disagreement with regulators on proposed protocols for such clinical trials;

• Delays in patient enrollment; or

• Changes in regulatory requirements and guidance that require amending or submitting new clinical protocols.

Any inability for us or our licensing partners to successfully complete preclinical and clinical development could result in additional costs to us or impair our or our licensing partners' ability to generate revenues from product sales, regulatory and commercialization milestones and royalties. Clinical trial delays could also shorten any periods during which we or our licensing partners may have the exclusive right to commercialize any product candidates or allow our competitors to bring products to market before we or our licensing partners do, which could impair our or our licensing partners' ability to successfully commercialize product candidates and may harm our business and results of operations.

If the results of any future clinical trials are inconclusive or if there are safety concerns or adverse events associated with any of our product candidates, we may:

• Be delayed in obtaining marketing approval for those product candidates, if at all;

• Obtain approval for indications or patient populations that are not as broad as intended or desired;

• Obtain approval with labelling that includes significant use or distribution restrictions or safety warnings;

• Be subject to changes in the way the product is administered;

• Be required to perform additional clinical trials to support approval or be subject to additional post-marketing testing requirements;

• Have regulatory authorities withdraw their approval of the product or impose restrictions on our distribution in the form of a risk evaluation and mitigations strategy, or REMS, program;

• Be subject to the addition of labelling statements, such as warnings or contraindications;

• Be sued; or

• Experience damage to our reputation.

Any product candidates could potentially cause other adverse events that have not yet been predicted. As described above, any of these events could prevent us or our licensing partners from achieving or maintaining market acceptance of product candidates and impair our or our licensing partners' ability to commercialize those products if they are ultimately approved by applicable regulatory authorities.

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***Any product candidates that we or any future licensing partners develop may cause undesirable side effects or have other properties that could halt their clinical development, prevent their regulatory approval, limit their commercial potential, or result in significant negative consequences.***

As with most biological drug products, use of any of our product candidates could be associated with side effects or adverse events which can vary in severity from minor reactions to death and in frequency from infrequent to prevalent. Undesirable side effects or unacceptable toxicities caused by our product candidates could cause us or regulatory authorities to interrupt, delay, or halt clinical trials. For example, on February 28, 2022, we announced our decision to voluntarily pause our Phase 1b KEYNOTE-B79 trial evaluating CYAD-101 administered concurrently with FOLFOX chemotherapy followed by MSD's anti-PD-1 therapy, KEYTRUDA<sup>®</sup> (pembrolizumab) in patients with refractory metastatic colorectal cancer following reports of two fatalities that presented with similar pulmonary findings. We investigated these reports and evaluated if there were any similar events in additional patients treated on study. Subsequently, on March 1, 2022, we were informed via e-mail communication from the FDA that the KEYNOTE-B79 trial has been placed on clinical hold due to insufficient information to assess risk to study subjects. The FDA lifted this clinical hold in July 2022 following our revision of the eligibility criteria for KEYNOTE-B79. We discontinued our development of CYAD-101 in October 2022 based on strategic considerations, including the delay to reaching milestones following the resolution of this clinical hold. No new safety concerns contributed to our decision to discontinue CYAD-101. The FDA, EMA, or comparable foreign regulatory authorities could delay or deny approval of any product candidates for any or all targeted indications and negative side effects could result in a more restrictive label for any product that is approved. Side effects such as toxicity or other safety issues associated with the use of product candidates could also require us or our collaborators to perform additional studies or halt development or sale of these product candidates.

Treatment-related side effects could also affect patient recruitment or the ability of enrolled subjects to complete the trial, or could result in potential product liability claims. In addition, these side effects may not be appropriately or timely recognized or managed by the treating medical staff. Any of these occurrences may materially and adversely harm our business, financial condition and prospects.

Additionally, if one or more of our product candidates receive marketing approval, and we or others later identify undesirable side effects caused by such products, including during any long-term follow-up observation period recommended or required for patients who receive treatment using our products, a number of potentially significant negative consequences could result, including:

• Regulatory authorities may withdraw approvals of or revoke licenses for such product;

• Regulatory authorities may require additional warnings on the label;

• We may be required to create a REMS program which could include a medication guide outlining the risks of such side effects for distribution to patients, a communication plan for healthcare providers, and/or other elements to assure safe use;

• We could be sued and held liable for harm caused to patients; and

• Our reputation may suffer.

Any of the foregoing could prevent us from achieving or maintaining market acceptance of the particular drug product candidate, if approved, and could significantly harm our business, results of operations, and prospects.

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***Clinical development is a lengthy and expensive process with an uncertain outcome, and results of earlier studies and trials as well as data from any interim analysis of ongoing clinical trials may not be predictive of future trial results. Clinical failure can occur at any stage of clinical development.***

Clinical testing is expensive and can take many years to complete, and the outcome is inherently uncertain. Failure can occur at any time during the clinical trial process. Although product candidates may demonstrate promising results in early clinical (human) trials and preclinical (animal) studies, they may not prove to be effective in subsequent clinical trials. For example, testing on animals may occur under different conditions than testing in humans and therefore the results of animal studies may not accurately predict human experience. Likewise, early clinical trials may not be predictive of eventual safety or effectiveness results in larger-scale pivotal clinical trials. The results of preclinical studies and previous clinical trials as well as data from any interim analysis of ongoing clinical trials of any of our product candidates, as well as studies and trials of other products with similar mechanisms of action to our product candidates, may not be predictive of the results of ongoing or future clinical trials. Drug product candidates in later stages of clinical trials may fail to show the desired safety and efficacy traits despite having progressed through preclinical studies and earlier clinical trials. In addition to the safety and efficacy traits of any drug product candidate, clinical trial failures may result from a multitude of factors including flaws in trial design, dose selection, placebo effect and patient enrollment criteria. Based upon negative or inconclusive results, we or our collaborators may decide, or regulators may require it, to conduct additional clinical trials or preclinical studies. In addition, data obtained from trials and studies are susceptible to varying interpretations, and regulators may not interpret our data as favorably as we do, which may delay, limit or prevent regulatory approval.

***The regulatory approval processes of the FDA, EMA and other comparable regulatory authorities is lengthy, time-consuming, and inherently unpredictable, and we may experience significant delays in the clinical development and regulatory approval, if any, of any product candidates.***

The research, testing, manufacturing, labelling, approval, selling, import, export, marketing, and distribution of drug products, including biologics, are subject to extensive regulation by the FDA, EMA and other comparable regulatory authorities. We are not permitted to market any biological drug product in the United States until we receive a license from the FDA for our biologics license application ("BLA"), or an approval of our marketing authorization application ("MAA") from the EMA. We have not previously submitted a BLA to the FDA, MAA to the EMA, or similar approval filings to comparable foreign authorities. A BLA must include extensive preclinical and clinical data and supporting information to establish that the drug product candidate is safe, pure, and potent for each desired indication. The BLA must also include significant information regarding the chemistry, manufacturing, and controls for the product, and the manufacturing facilities must complete a successful pre-license inspection. We expect the nature of any of our product candidates to create further challenges in obtaining regulatory approval. For example, the FDA and EMA have limited experience with commercial development of genetically modified T-cell therapies for cancer. The FDA may also require a panel of experts, referred to as an Advisory Committee, to deliberate on the adequacy of the safety and efficacy data to support licensure. The opinion of the Advisory Committee, although not binding, may have a significant impact on our ability to obtain licensure of the product candidates based on the completed clinical trials. Accordingly, the regulatory approval pathway for any of our product candidates may be uncertain, complex, expensive, and lengthy, and approval may not be obtained.

***Obtaining and maintaining regulatory approval of any product candidates in one jurisdiction does not mean that we, or our licensing partners, will be successful in obtaining regulatory approval of those product candidates in other jurisdictions.***

If we or our licensing partners obtain and maintain regulatory approval of any product candidates in one jurisdiction, such approval does not guarantee that we will be able to obtain or maintain regulatory approval in any other jurisdiction, but a failure or delay in obtaining regulatory approval in one jurisdiction may have a negative effect on the regulatory approval process in others. For example, even if the FDA or EMA grants marketing approval of a drug product candidate, comparable regulatory authorities in foreign jurisdictions must also approve the manufacturing, marketing and promotion of the drug product candidate in those countries. Approval procedures vary among jurisdictions and can involve requirements and administrative review periods different from those in the EU or in the United States, including additional preclinical studies or clinical trials as clinical trials conducted in one jurisdiction may not be accepted by regulatory authorities in other jurisdictions. In many jurisdictions, a drug product candidate must be approved for reimbursement before it can be approved for sale in that jurisdiction. In some cases, the price that we intend to charge for any future products is also subject to approval.

Obtaining foreign regulatory approvals and compliance with foreign regulatory requirements could result in significant delays, difficulties and costs for us and could delay or prevent the introduction of any future products in certain countries. If we or our licensing partners fail to comply with the regulatory requirements in international markets and/or to receive applicable marketing approvals, our target market will be reduced and our ability to realize the full market potential of our product candidates will be harmed.

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***We may seek designation for our TIM and/or shRNA technologies as designated platform technologies, but we might not receive such designation, and even if we do, such designation may not lead to a faster regulatory review or approval process.***

We may seek designation for our T cell receptor inhibitory molecule ("TIM") and/or short hairpin ribonucleic acids ("shRNA") technologies as designated platform technologies. Under the Food and Drug Omnibus Reform Act of 2022 ("FDORA"), a platform technology incorporated within or utilized by a drug or biological product is eligible for designation as a designated platform technology if (1) the platform technology is incorporated in, or utilized by, a drug approved under an BLA; (2) preliminary evidence submitted by the sponsor of the approved or licensed drug, or a sponsor that has been granted a right of reference to data submitted in the application for such drug, demonstrates that the platform technology has the potential to be incorporated in, or utilized by, more than one drug without an adverse effect on quality, manufacturing, or safety; and (3) data or information submitted by the applicable person indicates that incorporation or utilization of the platform technology has a reasonable likelihood to bring significant efficiencies to the drug development or manufacturing process and to the review process. A sponsor may request the FDA to designate a platform technology as a designated platform technology concurrently with, or at any time after, submission of an investigational new drug ("IND") application for a drug that incorporates or utilizes the platform technology that is the subject of the request. If so designated, the FDA may expedite the development and review of any subsequent original BLA for a drug that uses or incorporates the platform technology. Even if we believe TIM or shRNA meets the criteria for such designation, the FDA may disagree and instead determine not to grant such designation. In addition, the receipt of such designation for a platform technology does not ensure that a drug will be developed more quickly or receive FDA approval. Moreover, the FDA may revoke a designation if the FDA determines that a designated platform technology no longer meets the criteria for such designation.

***A Breakthrough Therapy Designation by the FDA for any product candidates may not lead to a faster development or regulatory review or approval process, and it does not increase the likelihood that those product candidates will receive marketing approval.***

We may seek a Breakthrough Therapy Designation for some of our product candidates. A breakthrough therapy is defined as a product that is intended, alone or in combination with one or more other products, to treat a serious or life-threatening disease or condition, and preliminary clinical evidence indicates that the product may demonstrate substantial improvement over existing therapies on one or more clinically significant endpoints, such as substantial treatment effects observed early in clinical development. For product candidates that have been designated as breakthrough therapies, interaction and communication between the FDA and the sponsor of the trial can help to identify the most efficient path for clinical development while minimizing the number of patients placed in ineffective control regimens. Drug product candidates designated as breakthrough therapies by the FDA may also be eligible for accelerated approval.

Designation as a breakthrough therapy is within the discretion of the FDA. Accordingly, even if we believe one of our product candidates meets the criteria for designation as a breakthrough therapy, the FDA may disagree and instead determine not to make such designation. In any event, the receipt of a Breakthrough Therapy Designation for a drug product candidate may not result in a faster development process, review or approval compared to drugs considered for approval under conventional FDA procedures and does not assure ultimate approval by the FDA. In addition, even if one or more of our product candidates qualify as breakthrough therapies, the FDA may later decide that the product candidates no longer meet the conditions for designation.

#### A Fast Track designation by the FDA may not actually lead to a faster development or regulatory review or approval process.
We may seek Fast Track designation for some of our product candidates. If a product is intended for the treatment of a serious or life-threatening condition and the product demonstrates the potential to address unmet medical needs for this condition, the product sponsor may apply for Fast Track designation. The FDA has broad discretion whether or not to grant this designation, so even if we believe a particular drug product candidate is eligible for this designation, we cannot assure you that the FDA would decide to grant it. Even if we do receive Fast Track designation, we may not experience a faster development process, review or approval compared to conventional FDA procedures. The FDA may withdraw Fast Track designation if it believes that the designation is no longer supported by data from any ongoing clinical development program.

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***We may seek orphan drug designation for some of our product candidates, and we may be unsuccessful or may be unable to maintain the benefits associated with orphan drug designation, including the potential for market exclusivity.***

As part of our business strategy, we may seek orphan drug designation for some of our product candidates, and we may be unsuccessful. Regulatory authorities in some jurisdictions, including the United States and the EU, may designate products for relatively small patient populations as orphan drugs. Under the Orphan Drug Act, the FDA may designate a product as an orphan drug if it is a product intended to treat a rare disease or condition, which is generally defined as a patient population of fewer than 200,000 individuals annually in the United States, or a patient population greater than 200,000 in the United States where there is no reasonable expectation that the cost of developing the product will be recovered from sales in the United States. In the United States, orphan drug designation entitles a party to financial incentives such as opportunities for grant funding towards clinical trial costs, tax advantages and user-fee waivers.

Similarly, in the EU, after recommendation from the EMA's Committee for Orphan Medicinal Products, the European Commission grants an orphan medicinal product designation in respect of a product if its sponsor can establish that the product is intended for the diagnosis, prevention or treatment of a life-threatening or chronically debilitating condition affecting no more than five in 10,000 persons in the EU and for which no satisfactory method of diagnosis, prevention, or treatment has been authorized for marketing in the EU (or, if such a method has been authorized, the product in question would be of a significant benefit to those affected by that condition). Additionally, designation is granted for products intended for the diagnosis, prevention, or treatment of a life-threatening, seriously debilitating or serious and chronic condition and when, without incentives, it is unlikely that sales of the product in the EU would generate sufficient return to justify the necessary investment in developing the product. In the EU, orphan medicinal product designation entitles a party to financial incentives such as reduction of fees or fee waivers.

Generally, if a drug product candidate with an orphan drug designation subsequently receives the first marketing approval for the indication for which it has such designation, the product is entitled to a period of marketing exclusivity, which precludes the EMA or the FDA from approving another marketing application for the same product and indication for that time period, except in limited circumstances. The applicable period is seven years in the United States and ten years in the EU. The EU exclusivity period can be reduced to six years if a product no longer meets the criteria for orphan medicinal product designation, including if the product is sufficiently profitable so that market exclusivity is no longer justified.

Even if we or our collaborators obtain orphan drug exclusivity for a future product, that exclusivity may not effectively protect the product from competition because different products can be approved for the same condition or the same products can be approved for different conditions. If one of our product candidates that receives an orphan drug designation is approved for a particular indication or use within the rare disease, the FDA may later approve the same product for additional indications or uses within that rare disease that are not protected by our exclusive approval. Even after an orphan drug is approved, the FDA can subsequently approve the same product for the same condition if the FDA concludes that the later product is clinically superior in that it is shown to be safer, more effective or makes a major contribution to patient care. In addition, a designated orphan drug may not receive orphan drug exclusivity if it is approved for a use that is broader than the indication for which it received orphan designation. Moreover, orphan drug exclusive marketing rights in the United States may be lost if the FDA later determines that the request for designation was materially defective or if the manufacturer is unable to assure sufficient quantity of the product to meet the needs of patients with the rare disease or condition. Orphan drug designation neither shortens the development time or regulatory review time of a product nor gives the product any advantage in the regulatory review or approval process. While we may seek orphan drug designation for product candidates, we may never receive such designations. Even if we do receive such designations, there is no guarantee that we will enjoy the benefits of those designations.

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***Even if we receive regulatory approval of any product candidates, we will be subject to ongoing regulatory obligations and continued regulatory review, which may result in significant additional expenses and we may be subject to penalties if we fail to comply with regulatory requirements or experience unanticipated problems with those product candidates.***

If any product candidates are approved, they will be subject to ongoing regulatory requirements for manufacturing, labeling, packaging, storage, advertising, promotion, sampling, record-keeping, conduct of post-marketing studies, and submission of safety, efficacy, and other post-market information, including both federal and state requirements in the United States and requirements of comparable foreign regulatory authorities.

Manufacturers and manufacturers' facilities are required to comply with extensive FDA, and comparable foreign regulatory authority, requirements, including ensuring that quality control and manufacturing procedures conform to current cGMP regulations and applicable product tracking and tracking requirements, and in certain cases current Good Tissue Practices ("cGTP") regulations. As such, we and any of our CMOs will be subject to continual review and inspections to assess compliance, to the extent applicable, with cGMP and adherence to commitments made in any BLA, other marketing application, and previous responses to inspection observations. Accordingly, we and others with whom we work must continue to expend time, money, and effort in all areas of regulatory compliance, including manufacturing, production, and quality control.

Any regulatory approvals that we or our licensing partners receive for any product candidates may be subject to limitations on the approved indicated uses for which the product may be marketed or to the conditions of approval, or contain requirements for potentially costly post-marketing testing, including Phase 4 clinical trials and surveillance to monitor the safety and efficacy of the drug product candidate. Additionally, under FDORA, sponsors of approved drugs and biologics must provide 6 months' notice to the FDA of any changes in marketing status, such as the withdrawal of a drug, and failure to do so could result in the FDA placing the product on a list of discontinued products, which would revoke the product's ability to be marketed. The FDA may also require a REMS program as a condition of approval of our product candidates, which could entail requirements for long-term patient follow-up, a medication guide, physician communication plans or additional elements to ensure safe use, such as restricted distribution methods, patient registries and other risk minimization tools. In addition, if the FDA or a comparable foreign regulatory authority approves a product candidate, we will have to comply with requirements including submissions of safety and other post-marketing information and reports, establishment registration, as well as continued compliance with cGMPs and GCPs for any clinical trials that we conduct post-approval.

The FDA may seek consent decrees or withdraw approval if compliance with regulatory requirements and standards is not maintained or if problems occur after the product reaches the market. Later discovery of previously unknown problems with any product candidates, including adverse events of unanticipated severity or frequency, or with our third-party manufacturers or manufacturing processes, or failure to comply with regulatory requirements, may result in revisions to the approved labeling to add new safety information; imposition of post-market studies or clinical trials to assess new safety risks; or imposition of distribution restrictions or other restrictions under a REMS program. Other potential consequences include, among other things:

• Restrictions on the marketing or manufacturing of future products, withdrawal of the product from the market, or voluntary or mandatory product recalls;

• Fines, untitled or warning letters, or holds on clinical trials;

• Refusal by the FDA to approve pending applications or supplements to approved applications filed by us or suspension or revocation of license approvals;

• Product seizure or detention, or refusal to permit the import or export of our product candidates; and

• Injunctions or the imposition of civil or criminal penalties.

The FDA strictly regulates marketing, labeling, advertising, and promotion of products that are placed on the market. Products may be promoted only for the approved indications and in accordance with the approved label. The FDA and other agencies actively enforce the laws and regulations prohibiting the promotion of off-label uses, and a company that is found to have improperly promoted off-label uses may be subject to significant liability. The policies

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of the FDA and of other regulatory authorities may change and additional government regulations may be enacted that could prevent, limit or delay regulatory approval of any product candidates. We cannot predict the likelihood, nature or extent of government regulation that may arise from future legislation or administrative action, either in the United States or abroad. If we are slow or unable to adapt to changes in existing requirements or the adoption of new requirements or policies, or if we are not able to maintain regulatory compliance, we may lose any marketing approval that we may have obtained and we may not achieve or sustain profitability.

***Even if we obtain regulatory approval of any product candidates, the products may not gain market acceptance among physicians, patients, hospitals and others in the medical community.***

Our product candidates may not become broadly accepted by physicians, patients, hospitals, and others in the medical community. Numerous factors will influence whether any of our product candidates are accepted in the market, including:

• The clinical indications for which those product candidates are approved;

• Physicians, hospitals, and patients considering those product candidates as a safe and effective treatment;

• The potential and perceived advantages of those product candidates over alternative treatments;

• The prevalence and severity of any side effects;

• Product labelling or product insert requirements of the FDA, EMA, or other regulatory authorities;

• Limitations or warnings contained in the labelling approved by the FDA or EMA;

• The timing of market introduction of those product candidates as well as competitive products;

• The cost of treatment in relation to alternative treatments;

• The availability of adequate coverage, reimbursement and pricing by third-party payors and government authorities;

• The willingness of patients to pay out-of-pocket in the absence of coverage by third-party payors and government authorities;

• Relative convenience and ease of administration, including as compared to alternative treatments and competitive therapies; and

• The effectiveness of our sales and marketing efforts.

In addition, although we do not plan to utilize embryonic stem cells in any product candidates, adverse publicity due to the ethical and social controversies surrounding the therapeutic use of such technologies, and reported side effects from any clinical trials using these technologies or the failure of such trials to demonstrate that these therapies are safe and effective may limit market acceptance of any of these product candidates due to the perceived similarity between our product candidates and these other therapies. If any of our product candidates are approved but fail to achieve market acceptance among physicians, patients, hospitals, or others in the medical community, we will not be able to generate significant revenue.

Even if our future products achieve market acceptance, we may not be able to maintain that market acceptance over time if new products or technologies are introduced that are more favorably received than our products, are more cost effective or render our products obsolete.

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***Any product candidates we develop, or technologies we license, will be biologics, which are complex to manufacture, and we or our licensing partners may encounter difficulties in production, particularly with respect to process development or scaling-out of manufacturing capabilities. If we, our licensing partners, or any of our third-party manufacturers encounter such difficulties, the ability to provide supply of these product candidates for clinical trials or products for patients, if approved, could be delayed or stopped, or we may be unable to maintain a commercially viable cost structure.***

Our patent portfolio and research and development focus on biologics and the process of manufacturing these types of products is complex, highly-regulated and subject to multiple risks. The manufacture of any product candidates derived from our intellectual property or that we develop may involve complex processes, including harvesting cells from patients, selecting and expanding certain cell types, engineering or reprogramming the cells in a certain manner to create CAR T-cells, expanding the cell population to obtain the desired dose, and ultimately infusing the cells back into a patient's body. As a result of the complexities, the cost to manufacture these product candidates is higher than traditional small molecule chemical compounds, and the manufacturing process is less reliable and is more difficult to reproduce. The manufacturing process for these product candidates is susceptible to product loss or failure due to logistical issues associated with the collection of blood cells, or starting material, from the patient, shipping such material to the manufacturing site, shipping the final product back to the patient, and infusing the patient with the product, manufacturing issues associated with the differences in patient starting materials, interruptions in the manufacturing process, contamination, equipment or reagent failure, improper installation or operation of equipment, vendor or operator error, inconsistency in cell growth, and variability in product characteristics. Even minor deviations from normal manufacturing processes could result in reduced production yields, product defects, and other supply disruptions. Because some of these product candidates may be manufactured for each particular patient, we, or our partners, would be required to maintain a chain of identity with respect to materials as they move from the patient to the manufacturing facility, through the manufacturing process, and back to the patient. Maintaining such a chain of identity is difficult and complex and failure to do so could result in adverse patient outcomes, loss of product, or regulatory action including withdrawal of products from the market. Further, as product candidates are developed through preclinical to late stage clinical trials towards approval and commercialization, it is common that various aspects of the development program, such as manufacturing methods, are altered along the way in an effort to optimize processes and results. Such changes carry the risk that they will not achieve these intended objectives, and any of these changes could cause these product candidates to perform differently and affect the results of ongoing clinical trials or other future clinical trials.

Developing a commercially viable processes for the manufacture of these types of product candidates is a difficult and uncertain task, and there are risks associated with scaling to the level required for later-stage clinical trials and commercialization, including, among others, cost overruns, potential problems with process scale-out, process reproducibility, stability issues, lot consistency, and timely availability of reagents or raw materials. We may ultimately be unable to reduce the cost of goods for any of our product candidates to levels that will allow for an attractive return on investment if and when those product candidates are commercialized.

In addition, the manufacturing process for any of our product candidates are subject to regulatory authorities' approval processes, and we will need to make sure that we, or our licensing partners or the appointed CMOs if any, are able to meet all regulatory authorities' requirements on an ongoing basis. If we, or our licensing partners or the appointed CMOs are unable to reliably produce product candidates to specifications acceptable to the regulatory authorities, we or our licensing partners may not obtain or maintain the approvals we need to commercialize such product candidates. Even if we or our licensing partners obtain regulatory approval for any of these product candidates, there is no assurance that either we, our licensed partners or the appointed CMOs will be able to manufacture the approved product to specifications acceptable to the regulatory authorities, to produce it in sufficient quantities to meet the requirements for the potential launch of the product, or to meet potential future demand. Any of these challenges could have an adverse effect on our business, financial condition, results of operations and growth prospects.

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#### We may face competition from biosimilars, which may have a material adverse impact on the future commercial prospects of any product candidates we pursue.
Even if we are successful in achieving regulatory approval to commercialize a drug product candidate faster than our competitors, we may face competition from biosimilars. The Biologics Price Competition and Innovation Act of 2009, or BPCI Act, created an abbreviated approval pathway for biological products that are demonstrated to be biosimilar to, or interchangeable with, an FDA-approved biological product. "Biosimilarity" means that the biological product is highly similar to the reference product notwithstanding minor differences in clinically inactive components and there are no clinically meaningful differences between the biological product and the reference product in terms of safety, purity, and potency of the product. To meet the higher standard of "interchangeability," an applicant must provide sufficient information to show biosimilarity and demonstrate that the biological product can be expected to produce the same clinical result as the reference product in any given patient and, if the biological product is administrated more than once to an individual, the risk in terms of safety or diminished efficacy of alternating or switching between the use of the biological product and the reference product is not greater than the risk of using the reference product without such alternation or switch.

A reference biological product is granted 12 years of exclusivity from the time of first licensure of the product, and the FDA will not accept an application for a biosimilar or interchangeable product based on the reference biological product until four years after first licensure. First licensure typically means the initial date the particular product at issue was licensed in the United States. This does not include a supplement for the biological product or a subsequent application by the same sponsor or manufacturer of the biological product (or licensor, predecessor in interest, or other related entity) for a change that results in a new indication, route of administration, dosing schedule, dosage form, delivery system, delivery device, or strength, unless that change is a modification to the structure of the biological product and such modification changes our safety, purity, or potency. Whether a subsequent application, if approved, warrants exclusivity as the first licensure of a biological product is determined on a case-by-case basis with data.

This data exclusivity does not prevent another company from developing a product that is highly similar to the innovative product, generating its own data, and seeking approval. Data exclusivity only assures that another company cannot rely upon the data within the application for the reference biological product to support the biosimilar product's approval.

In the EU, the European Commission has granted marketing authorizations for several biosimilars pursuant to a set of general and product class-specific guidelines for biosimilar approvals published by the EMA. In the EU, a competitor may reference the data supporting approval of an innovative biological product in its application for a biosimilar product, but will not be able do so until eight years after the time of approval of the innovative product and will not be able to get its biosimilar on the market until 10 years from the aforementioned approval. This 10-year marketing exclusivity period will be extended to 11 years if, during the first eight of those 10 years, the marketing authorization holder obtains an approval for one or more new therapeutic indications that bring significant clinical benefits compared with existing therapies. In addition, companies may be developing biosimilars in other countries that could compete with any of our future products.

If competitors are able to obtain marketing approval for biosimilars referencing our future products, our future products may become subject to competition from such biosimilars, with the attendant competitive pressure and consequences.

***Nearly all aspects of our activities are subject to substantial regulation. No assurance can be given that any of our product candidates will fulfill regulatory compliance. Failure to comply with such regulations could result in delays, suspension, refusals, fines and withdrawal of approvals.***

The international pharmaceutical and medical technology industry is highly regulated by government bodies (hereinafter the "Competent Authorities") that impose substantial requirements covering nearly all aspects of our current and potential future activities notably on research and development, manufacturing, preclinical tests, clinical trials, labelling, marketing, sales, storage, record keeping, promotion and pricing of our research programs and product candidates. Compliance with standards laid down by local Competent Authorities is required in each country where we, or any of our partners or licensees, conduct said activities in whole or in part. The Competent Authorities notably include the EMA in the EU and the FDA in the United States.

There can be no assurance that any of our product candidates will fulfill the criteria required to obtain necessary regulatory authorization to access the market. Also, at this time, we cannot guarantee or know the exact nature, precise timing and detailed costs of the efforts that will be necessary to complete the remainder of the development of our research programs or product candidates.

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The specific regulations and laws, as well as the time required to obtain Competent Authorities approvals, may vary from country to country, but the general regulatory procedures are similar in the EU and the United States. Each Competent Authority may impose its own requirements, may discontinue an approval, may refuse to grant approval, or may require additional data before granting approval, notwithstanding that approval may have been granted by one or more other Competent Authorities. Competent Authority approval may be delayed, limited or denied for a number of reasons, most of which are beyond our control. Such reasons include the production process or site not meeting the applicable requirements for the manufacture of regulated products, or the products not meeting applicable requirements for safety or efficacy during the clinical development stage or after marketing. No assurance can be given that clinical trials will be approved by Competent Authorities or that products will be approved for marketing by Competent Authorities in any pre-determined indication or intended use. Competent Authorities may disagree with our interpretation of data submitted for their review. Even after obtaining approval for clinical trials or marketing, products will be subject to ongoing regulation and evaluation of their benefit/safety or risk/performance ratio; a negative evaluation of the benefit/safety or risk/performance ratio could result in a potential use restriction and/or withdrawal of approval for one or more products. At any time, Competent Authorities may require discontinuation or holding of clinical trials or require additional data prior to completing their review or may issue restricted authorization or authorize products for clinical trials or marketing for narrower indications than requested or require further data or studies be conducted and submitted for their review. There can be no guarantee that such additional data or studies, if required, will corroborate earlier data.

***Research programs and any of our product candidates must undergo rigorous preclinical tests and clinical trials, the start, timing of completion, number and results of which are uncertain and could substantially delay or prevent the products from reaching the market.***

Preclinical tests and clinical trials are expensive and time-consuming, and their results are uncertain. We, our collaborative partners or other third parties may not successfully complete the preclinical tests and clinical trials of the research programs and product candidates. Failure to do so may delay or prevent the commercialization of products. We cannot guarantee that our research programs and any product candidates will demonstrate sufficient safety or efficacy or performance in our, or our partners', preclinical tests and clinical trials to obtain marketing authorization in any given territory or at all, and the results from earlier preclinical tests and clinical trials may not accurately predict the results of later-stage preclinical tests and clinical trials. At any stage of development, based on a review of available preclinical and clinical data, the estimated costs of continued development, market assessments and other factors, the development of any of our research programs and any product candidates may be suspended or discontinued.

We and our collaborative partners are, or may become subject to, numerous ongoing regulatory obligations, such as data protection, environmental, health and safety laws and restrictions on the experimental use of animals and/or human beings. The costs of compliance with applicable regulations, requirements or guidelines could be substantial,

and failure to comply could result in sanctions, including fines, injunctions, civil penalties, denial of applications for marketing authorization of any of our future products, delays, suspension or withdrawal of approvals, license revocation, seizures or recalls of products, operating restrictions and criminal prosecutions, any of which could significantly increase our or our collaborative partners' costs or delay the development and commercialization of our product candidates.

#### We may face significant competition and technological change which could limit or eliminate the market opportunity for any product candidates.
The market for pharmaceutical products is highly competitive. Our competitors include many established pharmaceutical, biotechnology, universities and other research or commercial institutions, many of which have substantially greater financial, research and development resources than us. The fields in which we operate are characterized by rapid technological change and innovation. There can be no assurance that our competitors are not currently developing or will not in the future develop technologies and products that are equally or more effective and/or are more economical as any current or future technology or product of ours. Competing products may gain faster or greater market acceptance than any of our future products and medical advances or rapid technological development by competitors may result in our product candidates becoming non-competitive or obsolete before we are able to recover our research and development and commercialization expenses. If we or our product candidates do not compete effectively, it may have a material adverse effect on our business.

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***The price setting, the availability and level of adequate reimbursement by third parties, such as insurance companies, governmental and other healthcare payers is uncertain and may impede on our ability to generate sufficient operating margins to offset operating expenses.***

In the United States and markets in other countries, patients generally rely on third-party payors to reimburse all, or part of the costs associated with their treatment. Adequate coverage and reimbursement from governmental healthcare programs, such as Medicare and Medicaid, and commercial payors is critical to new product acceptance. Our commercial performance will depend in part on the conditions for setting the sales price of our future products by the relevant public commissions and bodies and the conditions of their reimbursement by the health agencies or insurance companies in the countries where we intend to market any future products. Even if coverage is provided, the approved reimbursement amount may not be high enough to allow us to establish or maintain pricing sufficient to realize a sufficient return on our investment. Government authorities and third-party payors, such as private health insurers and health maintenance organizations, decide which medications they will pay for and establish reimbursement levels.

There has been heightened governmental scrutiny over the manner in which manufacturers set prices for their marketed products, which has resulted in several U.S. Congressional inquiries and proposed, and enacted federal and state legislation designed to, among other things, bring more transparency to drug pricing, reduce the cost of prescription drugs under Medicare, and review the relationship between pricing and manufacturer patient programs. At a federal level, President Biden signed an Executive Order on July 9, 2021, affirming the administration's policy to (i) support legislative reforms that would lower the prices of prescription drug and biologics, including by allowing Medicare to negotiate drug prices, by imposing inflation caps, and, by supporting the development and market entry of lower-cost generic drugs and biosimilars; and (ii) support the enactment of a public health insurance option. Among other things, the Executive Order also directs HHS to provide a report on actions to combat excessive pricing of prescription drugs, enhance the domestic drug supply chain, reduce the price that the Federal government pays for drugs, and address price gouging in the industry; and directs the FDA to work with states and Indian Tribes that propose to develop section 804 Importation Programs in accordance with the Medicare Prescription Drug, Improvement, and Modernization Act of 2003, and the FDA's implementing regulations. FDA released such implementing regulations on September 24, 2020, which went into effect on November 30, 2020, providing guidance for states to build and submit importation plans for drugs from Canada. On September 25, 2020, CMS stated drugs imported by states under this rule will not be eligible for federal rebates under Section 1927 of the Social Security Act and manufacturers would not report these drugs for "best price" or Average Manufacturer Price purposes. Since these drugs are not considered covered outpatient drugs, CMS further stated it will not publish a National Average Drug Acquisition Cost for these drugs. If implemented, importation of drugs from Canada may materially and adversely affect the price we receive for any of our product candidates. Further, on November 20, 2020, CMS issued an Interim Final Rule implementing the Most Favored Nation, or MFN, Model under which Medicare Part B reimbursement rates would have been calculated for certain drugs and biologicals based on the lowest price drug manufacturers receive in Organization for Economic Cooperation and Development countries with a similar gross domestic product per capita. However, on December 29, 2021, CMS rescinded the Most Favored Nations rule. Additionally, on November 30, 2020, HHS published a regulation removing safe harbor protection for price reductions from pharmaceutical manufacturers to plan sponsors under Part D, either directly or through pharmacy benefit managers, unless the price reduction is required by law. The rule also creates a new safe harbor for price reductions reflected at the point-of-sale, as well as a safe harbor for certain fixed fee arrangements between pharmacy benefit managers and manufacturers. Pursuant to court order, the removal and addition of the aforementioned safe harbors were delayed, and recent legislation imposed a moratorium on implementation of the rule until January 1, 2026. The Inflation Reduction Act of 2022 (the "IRA") delayed implementation of this rule to January 1, 2032.

Further, on December 31, 2020, CMS published a new rule, effective January 1, 2023, requiring manufacturers to ensure the full value of co-pay assistance is passed on to the patient or these dollars will count toward the Average Manufacturer Price and Best Price calculation of the drug. On May 21, 2021, PhRMA sued the HHS in the U.S. District Court for the District of Columbia, to stop the implementation of the rule claiming that the rule contradicts federal law surrounding Medicaid rebates. It is unclear how the outcome of this litigation will affect the rule. We cannot predict how the implementation of and any further changes to this rule will affect our business.

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In August 2022, the IRA was signed into law. The IRA includes several provisions that will impact our business to varying degrees, including provisions that create a $2,000 out-of-pocket cap for Medicare Part D beneficiaries, impose new manufacturer financial liability on all drugs in Medicare Part D, allow the U.S. government to negotiate Medicare Part B and Part D pricing for certain high-cost drugs and biologics without generic or biosimilar competition, require companies to pay rebates to Medicare for drug prices that increase faster than inflation, and delay the rebate rule that would require pass through of pharmacy benefit manager rebates to beneficiaries. The effect of IRA on our business and the healthcare industry in general is not yet known.

Although a number of these and other proposed measures may require authorization through additional legislation to become effective, and the Biden administration may reverse or otherwise change these measures, both the Biden administration and Congress have indicated that they will continue to seek new legislative measures to control drug costs.

We expect that additional U.S. federal healthcare reform measures will be adopted in the future, any of which could limit the amounts that the U.S. Federal Government will pay for healthcare drugs and services, which could result in reduced demand for any of our product candidates or additional pricing pressures.

Individual states in the United States have also become increasingly active in passing legislation and implementing regulations designed to control pharmaceutical and biological product pricing, including price or patient reimbursement constraints, discounts, restrictions on certain drug access and marketing cost disclosure and transparency measures, and designed to encourage importation from other countries and bulk purchasing. Legally mandated price controls on payment amounts by third-party payors or other restrictions could harm our business, financial condition, results of operations and prospects. In addition, regional healthcare authorities and individual hospitals are increasingly using bidding procedures to determine what pharmaceutical products and which suppliers will be included in their prescription drug and other healthcare programs. This could reduce the ultimate demand for our drugs or put pressure on our drug pricing, which could negatively affect our business, financial condition, results of operations and prospects.

The current context of healthcare cost control and economic and financial crisis that most countries are currently facing, coupled with the increase in health care budgets caused by the aging population creates extra pressure on health care spending in most if not all countries. Consequently, pressure on sales prices and reimbursement levels is intensifying owing in particular to:

• Price controls imposed by many states;

• The increasing reimbursement limitations of some products under budgetary policies;

• The heightened difficulty in obtaining and maintaining a satisfactory reimbursement rate for medicines.

In addition, in some foreign countries, the proposed pricing for a drug must be approved before it may be lawfully marketed. The requirements governing drug pricing vary widely from country to country. For example, the EU provides options for its Member States to restrict the range of medicinal products for which their national health insurance systems provide reimbursement and to control the prices of medicinal products for human use. To obtain reimbursement or pricing approval, some of these countries may require the completion of clinical trials that compare the cost effectiveness of a particular product candidate to currently available therapies. A Member State may approve a specific price for the medicinal product, or it may instead adopt a system of direct or indirect controls on the profitability of the company placing the medicinal product on the market. There can be no assurance that any country that has price controls or reimbursement limitations for pharmaceutical products will allow favorable reimbursement and pricing arrangements for any of our product candidates. Historically, products launched in the EU do not follow price structures of the U.S. and generally prices tend to be significantly lower.

Obtaining adequate pricing decisions that would generate return on the investment incurred for the development of the product candidates developed by us are therefore uncertain. Our ability to manage our expenses and cost structure to adapt to increased pricing pressure is untested and uncertain.

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All of these factors will have a direct impact on our ability to make profits on the products in question. The partial/no reimbursement policy of medicines could have a material adverse effect on the business, prospects, financial situation, earnings and our growth.

#### Changes in regulatory approval policies or enactment of additional regulatory approval requirements may delay or prevent any of our product candidates from being marketed.
The regulatory clearance process is expensive and time consuming and the timing of marketing is difficult to predict. Once marketed, products may be subject to post-authorization safety studies or other pharmacovigilance or vigilance activities or may be subject to limitations on their uses or may be withdrawn from the market for various reasons, including if they are shown to be unsafe or ineffective, or when used in a larger population that may be different from the trial population studied prior to market introduction of the product.

Any product candidates we or our licensing partners develop may become subject to changes in the regulatory framework or market conditions. Regulatory guidelines may change during the course of product development and review process, making the chosen development strategy suboptimal. Market conditions may change resulting in the emergence of new competitors or new treatment guidelines which may require alterations in the development strategy. These factors may result in significant delays, increased trial costs, significant changes in commercial assumptions or failure of the products to obtain marketing authorization.

***Changes in funding for the FDA and other government agencies, including from government shutdowns or other disruptions to these agencies' operations, could hinder their ability to hire and retain key leadership and other personnel, or otherwise prevent new products from being developed or commercialized in a timely manner, which could negatively impact our business.***

The ability of the FDA to review and approve new products can be affected by a variety of factors, including government budget and funding levels, the ability to hire and retain key personnel, the ability to accept the payment of user fees, and statutory, regulatory and policy changes. Average review times at the agency have fluctuated in recent years as a result. In addition, government funding of the SEC and other government agencies on which our operations may rely, including those that fund research and development activities, is subject to the political process, which is inherently fluid and unpredictable.

Disruptions at the FDA and other agencies may slow the time necessary for new products to be reviewed and/or approved by necessary government agencies, which would adversely affect our business. Our business depends upon the ability of the FDA to accept and review our, or our partners', potential regulatory filings. If a prolonged government shutdown occurs, it could significantly impact the ability of the FDA to timely review and process these regulatory submissions, which could have a material adverse effect on our ability to advance clinical development of these product candidates. Further, future shutdowns of other government agencies, such as the SEC, may also impact our business through review of our public filings and our ability to access the public markets.

Since March 2020 when foreign and domestic inspections of facilities were largely placed on hold, the FDA has been working to resume pre-pandemic levels of inspection activities, including routine surveillance, bioresearch monitoring and pre-approval inspections. Should FDA determine that an inspection is necessary for approval and an inspection cannot be completed during the review cycle due to restrictions on travel, and the FDA does not determine a remote interactive evaluation to be adequate, the agency has stated that it generally intends to issue, depending on the circumstances, a complete response letter or defer action on the application until an inspection can be completed. During the COVID-19 public health emergency, a number of companies announced receipt of complete response letters due to the FDA's inability to complete required inspections for their applications. Regulatory authorities outside the U.S. may adopt similar restrictions or other policy measures in response to the ongoing COVID-19 pandemic and may experience delays in their regulatory activities.

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***We are subject to inspection and shall be subject to market surveillance by the FDA, EMA and other Competent Authorities for compliance with regulations that prohibit the promotion of future products for a purpose or indication other than those for which approval has been granted.***

While a product manufacturer may not promote a product for such "off label" use, doctors are allowed, in the exercise of their professional judgment in the practice of medicine, to use a product in ways not approved by Competent Authorities. Off-label marketing regulations are subject to varying evolving interpretations.

Post-approval manufacturing and marketing of any future products of ours may show different safety and efficacy profiles to those demonstrated in the data on which approval to test or market said products was based. Such circumstances could lead to the withdrawal or suspension of approval, which could have a material adverse effect on our business, financial condition, operating results or cash flows. In addition, Competent Authorities may not approve the labelling claims or advertisements that are necessary or desirable for the successful commercialization of any future products we seek to develop.

Competent Authorities have broad enforcement power, and a failure by us or our collaboration partners to comply with applicable regulatory requirements can, among other things, result in recalls or seizures of products, operating and production restrictions, withdrawals of previously approved marketing applications, total or partial suspension of regulatory approvals, refusal to approve pending applications, warning letters, injunctions, penalties, fines, civil proceedings, criminal prosecutions and imprisonment.

#### We may fail to comply with evolving European and other privacy laws.
The collection and use of personal data in the EU is governed by Regulation (EU) 2016/679 of the European Parliament and of the Council of April 27, 2016, on the protection of natural persons with regard to the processing of personal data and on the free movement of such data (the "GDPR"). The GDPR imposes a broad range of strict requirements on companies subject to the GDPR, such as us, including requirements relating to having legal bases for processing personal information (i.e. information relating to identified or identifiable individuals) and transferring such information outside the European Economic Area (the "EEA"), including to the United States, providing details to those individuals regarding the processing of their personal information, keeping personal information secure, having data processing agreements with third parties who process personal information, responding to individuals' requests to exercise their rights in respect of their personal information, reporting security breaches involving personal data to the competent national data protection authority and affected individuals, appointing data protection officers, conducting data protection impact assessments, and record-keeping. The GDPR focuses strongly on accountability of data controllers (such as us) and requires us to take all technical and organizational measures (privacy by design and by default) to ensure that we meet our obligations. Failure to comply with the requirements of the GDPR, and the related national data protection laws of the EU Member States, may result in fines and other administrative penalties, including potential fines of up to €10,000,000 or up to 2% of our total worldwide annual turnover for certain comparatively minor offenses, or up to €20,000,000 or up to 4% of our total worldwide annual turnover for more serious offenses. In addition, further to the UK's exit from the EU on January 31, 2020, the GDPR ceased to apply in the UK at the end of the transition period on December 31, 2020. However, as of January 1, 2021, the UK's European Union (Withdrawal) Act 2018 incorporated the GDPR (as it existed on December 31, 2020, but subject to certain UK specific amendments) into UK law, referred to as the UK GDPR. The UK GDPR and the UK Data Protection Act 2018 set out the UK's data protection regime, which is independent from but aligned to the EU's data protection regime. The UK Government has announced plans to reform its data protection legal framework in its Data Reform Bill but those have been put on hold. Non-compliance with the UK GDPR may result in monetary penalties of up to £17.5 million or 4% of worldwide revenue, whichever is higher. Although the UK is regarded as a third country under the EU's GDPR, the European Commission has now issued a decision recognizing the UK as providing adequate protection under the EU GDPR and, therefore, transfers of personal data originating in the EU to the UK remain unrestricted. Like the EU GDPR, the UK GDPR restricts personal data transfers outside the UK to countries not regarded by the UK as providing adequate protection. The UK government has confirmed that personal data transfers from the UK to the EU remain free flowing. Given this robust new legislative framework and the nascent jurisprudence developing in our wake, we face considerable uncertainty as to the correct interpretation and implementation of the GDPR requirements and may be unsuccessful in implementing all technical and organizational measures required by data protection authorities or courts.

In addition to the direct applicability of the GDPR per se, national laws of EU Member States are also in the process of being adapted to the requirements of the GDPR, notably in areas where the GDPR gives leeway to EU Member States to fill in the gaps-thereby implementing national laws which may partially deviate from the GDPR and impose different obligations from country to country, so that we cannot expect to operate in a uniform legal landscape in the EU. Thus, in the field of handling genetic data for instance, the GDPR specifically allows national laws to impose additional and more specific requirements or restrictions, and European laws have historically differed quite substantially in this field, leading to additional uncertainty.

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We must also ensure that we maintain adequate safeguards to enable the transfer of personal data outside of the EEA in compliance with European data protection laws, in particular to the United States. The EU-U.S. and the Swiss-U.S. Privacy Shield frameworks allowed U.S. companies that self-certify to the U.S. Department of Commerce and publicly commit to comply with specified requirements to import personal data from the EU and Switzerland. In 2020, the Court of Justice of the EU ("ESJ") invalidated the EU-U.S. Privacy Shield, which was one of the primary mechanisms used by U.S. companies to import personal information from Europe in compliance with the GDPR's cross-border data transfer restrictions, and raised questions about whether the European Commission's Standard Contractual Clauses, or SCCs, one of the primary alternatives to the Privacy Shield, can lawfully be used for personal information transfers from Europe to the United States or most other countries. Similarly, the Swiss Federal Data Protection and Information Commissioner has opined that the Swiss-U.S. Privacy Shield is inadequate for transfers of data from Switzerland to the U.S., and the UK Information Commissioner's Office has stated that the Privacy Shield framework is inadequate for transfers from the UK to the U.S. The ECJ ruled that transfers made pursuant to the SCCs need to be assessed on a case-by-case basis to ensure the law in the recipient country provides "essentially equivalent" protections to safeguard the transferred personal data as the EU, and required businesses to adopt supplementary measures if such standard is not met.

On March 25, 2022, the European Commission and the U.S. announced to have reached a political agreement on a new "Trans-Atlantic Data Privacy Framework", which will replace the invalidated Privacy Shield and on December 13, 2022, the EC published a draft adequacy decision on the Trans-Atlantic Data Privacy Framework.

On June 4, 2021, the European Commission issued new forms of SSCs for data transfers from controllers or processors in the EEA (or otherwise subject to the GDPR) to controllers or processors established outside the EEA. The new form of SCCs account for the CJEU's decision and other developments, and need to be put in place for new contracts involving the transfer of personal data from the EU to a third country since September 27, 2021, and incorporated into existing contracts since December 27, 2022. The new standard contractual clauses do not apply to the U.K., but the U.K. Information Commissioner's Office has published its own transfer mechanism, the International Data Transfer Agreement ("U.K. IDTA"), which entered into force on 21 March 2022, and enables data transfers originating from the U.K. It requires a similar assessment of the data protection provided in the importer's country. The U.K. IDTA needs to be concluded in new contracts involving the transfer of personal data from the U.K. since 22 September 2022. The new standard contractual clauses may impact our business as companies based in Europe and in the United States may be reluctant to utilize the new clauses to legitimize transfers of personal information to third countries given the burdensome requirements of transfer impact assessments and the substantial obligations that the new standard contractual clauses impose upon exporters. If we are investigated by a European or UK data protection authority, we may face fines and other penalties. Any such investigation or charges by European or UK data protection authorities could have a negative effect on our existing business and on our ability to attract and retain new clients or pharmaceutical partners. We may also experience hesitancy, reluctance, or refusal by European or multi-national clients or pharmaceutical partners to continue to use our products due to the potential risk exposure as a result of the current (and, in particular, future) data protection obligations imposed on them by certain data protection authorities in interpretation of current law, including the GDPR. Such clients or pharmaceutical partners may also view any alternative approaches to compliance as being too costly, too burdensome, too legally uncertain, or otherwise objectionable and therefore decide not to do business with us. Any of the foregoing could materially harm our business, prospects, financial condition, and results of operations.

#### Risks Related to Our Reliance on Third Parties
***We have obtained and will seek to obtain significant funding from the Walloon Region. The terms of the agreements signed with the Region may hamper our ability to partner part or all of our products.***

We contracted over the past year numerous funding agreements with the Walloon Region to partially finance our research and development programs. Under the terms of the agreements, we would need to obtain the consent of the Walloon Region for any out-licensing agreement or sale to a third party of any or all of our products, prototypes or installations which may reduce our ability to partner or sell part or all of our products.

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Furthermore, when the research and development programs partially financed by us enter in "exploitation phase", we have to start reimbursing the funding received. We may not be able to reimburse such funding under the terms of the agreements or such reimbursement may jeopardize the funding of our clinical and scientific activities.

#### We rely and will continue to rely on collaborative partners regarding the development of our research programs and any product candidates.
We are and expect to continue to be dependent on collaborations with partners relating to the development and commercialization of our existing and future research programs and product candidates. We had, have and will continue to have discussions on potential partnering opportunities with various pharmaceutical and medical device companies. If we fail to enter into or maintain collaborative agreements on reasonable terms or at all, our ability to develop our existing or future research programs and any future product candidates could be delayed, the commercial potential of our research programs and products could change, and our costs of development and commercialization could increase.

Our dependence on collaborative partners subjects it to a number of risks, including, but not limited to, the following:

• We may not be able to control the amount or timing of resources that collaborative partners devote to our research programs and any of our product candidates;

• We may be required to relinquish significant rights, including intellectual property, marketing and distribution rights;

• We rely on the information and data received from third parties regarding our research programs and any of our product candidates and will not have control of the process conducted by the third party in gathering and composing such data and information. We may not have formal or appropriate guarantees from our contract parties with respect to the quality and the completeness of such data;

• A collaborative partner may develop a competing product either by itself or in collaboration with others, including one or more of our competitors;

• Our collaborative partners' willingness or ability to complete their obligations under our collaboration arrangements may be adversely affected by business combinations or significant changes in a collaborative partner's business strategy; and/or

• We may experience delays in, or increases in the costs of, the development of our research programs and any product candidates due to the termination or expiration of collaborative research and development arrangements.

***If we, or our licensing partners, initiate any clinical development programs, we or our licensing partners will rely on third parties to conduct, supervise and monitor such clinical trials. If these third parties do not successfully carry out their contractual duties or meet expected deadlines, we or our licensing partners may not be able to obtain regulatory approval for or commercialize any product candidates and our business could be substantially harmed.***

We or our licensing partners will rely on clinical research organizations, or CROs, clinical investigators and clinical trial sites to ensure any future clinical trials are conducted properly and on time. Even if we, or our licensing partners, have agreements in place governing their activities, we or our licensing partners will have limited influence over their actual performance. We or our licensing partners will control only certain aspects of the CROs' activities. Nevertheless, we or our licensing partners will be responsible for ensuring that each of our product candidate clinical trials is conducted in accordance with the applicable protocol, legal and regulatory requirements and scientific standards, and reliance on these third parties does not relieve us or our licensing partners of our or their regulatory responsibilities.

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We or our licensing partners and these third parties are required to comply with the FDA's GCPs for conducting, recording and reporting the results of clinical trials to assure that the data and reported results are credible and accurate and that the rights, integrity and confidentiality of clinical trial participants are protected. The FDA, the Competent Authorities of the Member States of the EEA, and comparable foreign regulatory authorities enforce these GCPs through periodic inspections of trial sponsors, principal investigators and clinical trial sites. If we, our licensing partners or these third parties fail to comply with applicable GCPs, the clinical data generated in any future clinical trials we or our licensing partners conduct may be deemed unreliable and the FDA, the EMA, or other foreign regulatory authorities may require us to perform additional clinical trials before approving any marketing applications. Upon inspection, the FDA may determine that such clinical trials did not comply with GCPs. In addition, our or our licensing partners' future clinical trials will require a sufficient number of test subjects to evaluate the safety and effectiveness of any product candidates. Accordingly, if our or our licensing partners' CROs fail to comply with these regulations or fail to recruit a sufficient number of patients, we or our licensing partners may be required to repeat such clinical trials, which would delay the regulatory approval process.

These third parties are not our nor our licensing partners' employees, and we and our licensing partners are therefore unable to directly monitor whether or not they devote sufficient time and resources to our or our licensing partners' clinical and preclinical programs. These third parties may also have relationships with other commercial entities, including our competitors, for whom they may also be conducting clinical trials or other product development activities that could harm our competitive position. If these third parties do not successfully carry out their contractual duties or obligations, fail to meet expected deadlines, or if the quality or accuracy of the clinical data they obtain is compromised due to the failure to adhere to the clinical protocols or regulatory requirements, or for any other reasons, our or our licensing partners' clinical trials may be extended, delayed or terminated, and we or our licensing partners may not be able to obtain regulatory approval for, or successfully commercialize, the product candidates. If any such event were to occur, our financial results and the commercial prospects for our product candidates would be harmed, our costs could increase, and our ability to generate revenues could be delayed.

If any of our relationships with these third-party CROs terminate, we or our licensing partners may not be able to enter into arrangements with alternative CROs or to do so on commercially reasonable terms. Further, switching or adding additional CROs involves additional costs and requires management time and focus. In addition, there is a natural transition period when a new CRO commences work. As a result, delays occur, which could materially impact our or our licensing partners' ability to meet desired clinical development timelines. Though we carefully manage our relationships with our CROs, there can be no assurance that we will not encounter challenges or delays in the future or that these delays or challenges will not have a material adverse impact on our business, financial condition and prospects.

#### Cell-based therapies rely on the availability of specialty raw materials, which may not be available to us on acceptable terms or at all.
Engineered-cell therapies require many specialty raw materials, some of which are manufactured by small companies with limited resources and experience to support a commercial product. The suppliers may be ill-equipped to support our needs, especially in non-routine circumstances like an FDA inspection or medical crisis, such as widespread contamination, or a pandemic such as COVID-19. We also do not have contracts with many of these suppliers, and may not be able to contract with them on acceptable terms or at all. Accordingly, we may experience delays in receiving key raw materials to support clinical or commercial manufacturing. The global impact on supply chains has been one such example seen during 2021 where many supplies were reduced in availability for a short period of time.

In addition, some raw materials are currently available from a single supplier, or a small number of suppliers. We cannot be sure that these suppliers will remain in business, or that they will not be purchased by one of our competitors or another company that is not interested in continuing to produce these materials for our intended purpose.

Since the beginning of the COVID-19 pandemic, several vaccines for COVID-19 were granted Emergency Use Authorization by the FDA and a number of those later received marketing approval. The resultant demand for vaccines and potential for manufacturing facilities and materials to be commandeered under the Defense Production Act of 1950, or equivalent foreign legislation, may make it more difficult to obtain materials or manufacturing slots for the products needed for any future clinical trials, which could lead to delays in these trials.

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#### Risks Related to Our Intellectual Property
***If we are unable to obtain and maintain patent protection for any products we develop and for our technology, or if the scope of the patent protection obtained is not sufficiently broad, our competitors could develop and commercialize products and technology similar or identical to ours, and our ability to commercialize any product candidates we may develop, and our technology may be adversely affected.***

Our success depends in large part on our ability to obtain and maintain patent protection in the United States and other countries with respect to our product candidates, their respective components, formulations, combination therapies, methods used to manufacture them and methods of treatment and development that are important to our business. If we do not adequately protect our intellectual property rights, competitors may be able to erode or negate any competitive advantage we may have, which could harm our business and ability to achieve profitability. To protect our proprietary position, we file patent applications in the United States and abroad related to our novel product candidates that are important to our business; we may in the future also license or purchase patent applications filed by others. If we are unable to secure or maintain patent protection with respect to our technology and any proprietary products and technology we develop, our business, financial condition, results of operations, and prospects could be materially harmed.

If the scope of the patent protection we or our potential licensors obtain is not sufficiently broad, we may not be able to prevent others from developing and commercializing technology and products similar or identical to ours. The degree of patent protection we require to successfully compete in the marketplace may be unavailable or severely limited in some cases and may not adequately protect our rights or permit us to gain or keep any competitive advantage. We cannot provide any assurances that any of our patents have, or that any of our pending patent applications that mature into issued patents will include, claims with a scope sufficient to protect any product candidates or otherwise provide any competitive advantage. In addition, to the extent that we license intellectual property in the future, we cannot assure you that those licenses will remain in force. In addition, the laws of foreign countries may not protect our rights to the same extent as the laws of the United States. Furthermore, patents have a limited lifespan. In the United States, the natural expiration of a patent is generally 20 years after it is filed (21 years if first filed as a provisional application). Various extensions may be available; however, the life of a patent, and the protection it affords, is limited. Given the amount of time required for the development, testing and regulatory review of new product candidates, patents protecting such candidates might expire before or shortly after such candidates are commercialized.

Even if they are unchallenged, our patents and pending patent applications, if issued, may not provide us with any meaningful protection or prevent competitors from designing around our patent claims to circumvent our patents by developing similar or alternative technologies or therapeutics in a non-infringing manner. For example, a third party may develop a competitive therapy that provides benefits similar to one or more of our product candidates but that uses a formulation and/or a device that falls outside the scope of our patent protection. If the patent protection provided by the patents and patent applications we hold or pursue with respect to our product candidates is not sufficiently broad to impede such competition, our ability to successfully commercialize our product candidates could be negatively affected, which would harm our business. We currently own or have exclusively in-licensed all of our patents or patent applications. Similar risks would apply to any patents or patent applications that we may own and those which we may license in the future. In many cases, in-licensed intellectual property is at greater risk, as we may not have access to all information or to prosecution and other aspects of the acquisition, maintenance and enforcement of the in-licensed intellectual property.

Patent positions of life sciences companies can be uncertain and involve complex factual and legal questions. No consistent policy governing the scope of claims allowable in the fields of antibodies and radiopharmaceuticals has emerged in the United States. The scope of patent protection in jurisdictions outside of the United States is also uncertain. Changes in either the patent laws or their interpretation in any jurisdiction that we seek patent protection may diminish our ability to protect our inventions, maintain and enforce our intellectual property rights; and, more generally, may affect the value of our intellectual property, including the narrowing of the scope of our patents and any that we may license.

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The patent prosecution process is complex, expensive, time-consuming and inconsistent across jurisdictions. We may not be able to file, prosecute, maintain, enforce, or license all necessary or desirable patent rights at a commercially reasonable cost or in a timely manner. In addition, we may not pursue or obtain patent protection in all relevant markets. It is possible that we will fail to identify important patentable aspects of our research and development efforts in time to obtain appropriate or any patent protection. While we enter into non-disclosure and confidentiality agreements with parties who have access to confidential or patentable aspects of our research and development efforts, including for example, our employees, corporate collaborators, external academic scientific collaborators, CROs, contract manufacturers, consultants, advisors and other third parties, any of these parties may breach the agreements and disclose such output before a patent application is filed, thereby endangering our ability to seek patent protection. In addition, publications of discoveries in the scientific and scholarly literature often lag behind the actual discoveries, and patent applications in the United States and other jurisdictions are typically not published until 18 months after filing, or in some cases not until issuance as a patent. Consequently, we cannot be certain that we were the first to file for patent protection on the inventions claimed in our patents or pending patent applications.

The issuance, scope, validity, enforceability and commercial value of our patent rights are highly uncertain. Further, the scope of the invention claimed in a patent application can be significantly reduced before the patent is issued, and this scope can be reinterpreted after issuance. Even where patent applications we currently own, license, or that we may license in the future issue as patents, they may not issue in a form that will provide us with adequate protection to prevent competitors or other third parties from competing with us, or otherwise provide us with a competitive advantage. Any patents that eventually issue may be challenged, narrowed or invalidated by third parties. Consequently, we do not know whether any of our product candidates will be protectable or remain protected by valid and enforceable patent rights. Our competitors or other third parties may be able to evade our patent rights by developing alternative technologies or products in a non-infringing manner.

The issuance or grant of a patent is not irrefutable as to its inventorship, scope, validity or enforceability, and our patents may be challenged in the courts or patent offices in the United States and abroad. There may be prior art of which we are not aware that may affect the validity or enforceability of a patent claim. There also may be prior art of which we are aware, but which we do not believe affects the validity or enforceability of a claim, which may, nonetheless, ultimately be found to affect the validity or enforceability of a claim. We may in the future, become subject to a third-party pre-issuance submission of prior art or opposition, derivation, revocation, re-examination, post-grant and *inter partes* review, or interference proceeding and other similar proceedings challenging our patent rights or the patent rights of others in the U.S. Patent and Trademark Office, or the USPTO, or other foreign patent office. An unfavorable determination in any such submission, proceeding or litigation could reduce the scope of, or invalidate, our patent rights, allow third parties to commercialize our technology or products and compete directly with us, without payment to us, or extinguish our ability to manufacture or commercialize products without infringing third-party patent rights.

In addition, given the amount of time required for the development, testing and regulatory review of new product candidates, patents protecting such candidates might expire before or shortly after such candidates are commercialized. As a result, our intellectual property may not provide us with sufficient rights to exclude others from commercializing products similar or identical to ours. Moreover, some of our owned and in-licensed patents and patent applications are, and may in the future be, co-owned with third parties. If we are unable to obtain an exclusive license to any such third-party co-owners' interest in such patents or patent applications, such co-owners may be able to license their rights to other third parties, including our competitors, and our competitors could market competing products and technology. In addition, we or our licensors may need the cooperation of any such co-owners of our owned and in-licensed patents in order to enforce such patents against third parties, and such cooperation may not be provided to us or our licensors. Any of the foregoing could have a material adverse effect on our competitive position, business, financial conditions, results of operations and prospects.

#### We may infringe on the patents or intellectual property rights of others and may face patent litigation, which may be costly and time consuming.
Our success will depend in part on our ability to operate without infringing or misappropriating the intellectual property rights of others. We cannot guarantee that our activities will not infringe on the patents or other intellectual property rights owned by others. We may expend significant time and effort and may incur substantial costs in litigation if it is required to defend against patent or other intellectual property right suits brought against us regardless of whether the claims have any merit. Additionally, we cannot predict whether we will be successful in any litigation. If we are found to infringe the patents or other intellectual property rights of others, we may be subject to substantial claims for damages, which could materially impact our cash flow and financial position. We may also be required to cease development, use or sale of the relevant research program, product candidate or process or it may be required to obtain a license to the disputed rights, which may not be available on commercially reasonable terms, if at all.

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There can be no assurance that we are even aware of third-party rights that may be alleged to be relevant to any particular product candidate, method, process or technology.

We may spend significant time and effort and may incur substantial costs if required to defend against any infringement claims or to assert our intellectual property rights against third parties. The risk of such a claim by a third party may be increased by our public announcement regarding our research programs and product candidates. We may not be successful in defending our rights against such claims and may incur as a consequence thereof significant losses, costs or delays in our intended commercialization plans as a result thereof.

***We depend on intellectual property licensed from third parties and termination of any of these licenses could result in the loss of significant rights, which would harm our business.***

We are dependent on patents, know-how, and proprietary technology, both our own and licensed from others. We license technology from the Trustees of Dartmouth College, or Dartmouth College. Dartmouth College may terminate our license, if we fail to meet a milestone within the specified time period, unless we pay the corresponding milestone payment. Dartmouth College may terminate either the license in the event we default or breach any of the provisions of the applicable license, subject to 30 days' prior notice and opportunity to cure. In addition, the license automatically terminates in the event we become insolvent, make an assignment for the benefit of creditors or file, or have filed against us, a petition in bankruptcy. Furthermore, Dartmouth College may terminate our license, after April 30, 2024, if we fail to meet the specified minimum net sales obligations for any year, unless we pay to Dartmouth College the royalty, we would otherwise be obligated to pay had we met such minimum net sales obligation. We also license technology from Horizon Discovery Limited, or Horizon Discovery. Horizon Discovery may terminate our license in case of insolvency, material breach or force majeure. Any termination of these licenses or any of our other licenses could result in the loss of significant rights and could harm our ability to commercialize our product candidates. Disputes may also arise between us and our licensors regarding intellectual property subject to a license agreement, including those relating to:

• The scope of rights granted under the license agreement and other interpretation-related issues;

• Whether and the extent to which our technology and processes infringe on intellectual property of the licensor that is not subject to the license agreement;

• Our right to sublicense patent and other rights to third parties under collaborative development relationships;

• The amount and timing of milestone and royalty payments;

• Whether we are complying with our diligence obligations with respect to the use of the licensed technology in relation to our development and commercialization of our product candidates; and

• The allocation of ownership of inventions and know-how resulting from the joint creation or use of intellectual property by us and our partners and by our licensors.

If disputes over intellectual property that we have licensed prevent or impair our ability to maintain our current licensing arrangements on acceptable terms, we may be unable to successfully develop and commercialize the affected product candidates. We are generally also subject to all of the same risks with respect to protection of intellectual property that we license as it is for intellectual property that we own, which are described below. If we or our licensors fail to adequately protect this intellectual property, our ability to commercialize our products could suffer.

These agreements impose numerous obligations, such as diligence and payment obligations. Our licenses may be terminated if we are unable to meet the payment obligations under the agreements (notably if we are unable to obtain additional financing).

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We are generally also subject to all of the same risks with respect to protection of intellectual property that we license, as we are for intellectual property that we own, which are described below. If we or our licensors fail to adequately protect this intellectual property, our ability to commercialize products could suffer.

***If we fail to comply with our obligations under our patent licenses with third parties, we could lose license rights that are important to our business.***

We are a party to license agreements with Dartmouth College and Horizon Discovery and others, pursuant to which we in-license key patent and patent applications for use in one or more of our product candidates. These existing licenses impose various diligence, milestone payment, royalty, insurance and other obligations on us. If we fail to comply with these obligations, the licensors may have the right to terminate the licenses, in which event we would not be able to develop or market the products covered by such licensed intellectual property.

We rely on certain of our licensors to file and prosecute patent applications and maintain patents and otherwise protect the intellectual property we license from them and may continue to do so in the future. We have limited control over these activities or any other intellectual property that may be related to our in-licensed intellectual property. For example, we cannot be certain that such activities by these licensors have been or will be conducted in compliance with applicable laws and regulations or will result in valid and enforceable patents and other intellectual property rights. We have limited control over the manner in which our licensors initiate an infringement proceeding against a third-party infringer of the intellectual property rights, or defend certain of the intellectual property that is licensed to us. It is possible that any licensors' infringement proceeding or defense activities may be less vigorous than had we conducted them ourselves.

#### We could be unsuccessful in obtaining or maintaining adequate patent protection for one or more of product candidates.
The patent application process is expensive and time-consuming, and we and our current or future licensors and licensees may not be able to apply for or prosecute patents on certain aspects of our product candidates or deliver technologies at a reasonable cost, in a timely fashion, or at all. It is also possible that we or our current licensors, or any future licensors or licensees, will fail to identify patentable aspects of inventions made in the course of development and commercialization activities before it is too late to obtain patent protection on them. Therefore, our patents and applications may not be prosecuted and enforced in a manner consistent with the best interests of our business. It is possible that defects of form in the preparation or filing of our patents or patent applications may exist, or may arise in the future, such as with respect to proper priority claims, inventorship, claim scope or patent term adjustments. Under our existing license agreements with the Trustees of Dartmouth College, we have the right, but not the obligation, to enforce our licensed patents. If our current licensors, or any future licensors or licensees, are not fully cooperative or disagree with us as to the prosecution, maintenance or enforcement of any patent rights, such patent rights could be compromised and we might not be able to prevent third parties from making, using, and selling competing products. If there are material defects in the form or preparation of our patents or patent applications, such patents or applications may be invalid and unenforceable. Moreover, our competitors may independently develop equivalent knowledge, methods, and know-how. Any of these outcomes could impair our ability to prevent competition from third parties, which may have an adverse impact on our business, financial condition and operating results.

We currently have issued patents and patent applications directed to our potential future product candidates and medical devices, and we anticipate that we will file additional patent applications in several jurisdictions, including several EU countries and the United States, as appropriate.

However, we cannot predict:

• If and when any patents will issue from patent applications;

• The degree and range of protection any issued patents will afford us against competitors, including whether third parties will find ways to invalidate or otherwise circumvent our patents;

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• Whether others will apply for or obtain patents claiming aspects similar to those covered by our patents and patent applications; or

• Whether we will need to initiate litigation or administrative proceedings to defend our patent rights, which may be costly whether we win or lose.

We cannot be certain, however, that the claims in our pending patent applications will be considered patentable by patent offices in various countries, or that the claims of any of our issued patents will be considered valid and enforceable by local courts.

The strength of patents in the biotechnology and pharmaceutical field can be uncertain, and evaluating the scope of such patents involves complex legal and scientific analyses. The patent applications that we own, or in-licenses may fail to result in issued patents with claims that cover our product candidates or uses thereof in the EU, in the United States or in other jurisdictions. Even if the patents do successfully issue, third parties may challenge the validity, enforceability, or scope thereof, which may result in such patents being narrowed, invalidated, or held unenforceable. Furthermore, even if they are unchallenged, our patents and patent applications may not adequately protect our intellectual property or prevent others from designing their products to avoid being covered by our claims. If the breadth or strength of protection provided by the patent applications, we hold with respect to our product candidates is threatened, this could dissuade companies from collaborating with us to develop, and could threaten our ability to commercialize, our product candidates. Further, because patent applications in most countries are confidential for a period of time after filing, we cannot be certain that we were the first to file any patent application related to our product candidates.

Patents have a limited lifespan. Various extensions may be available; however, the life of a patent, and the protection it affords, is limited. Further, the extensive period of time between patent filing and regulatory approval for a drug product candidate limits the time during which we can market a drug product candidate under patent protection, which may particularly affect the profitability of our early-stage product candidates. If we encounter delays in our clinical trials, the period of time during which we could market our product candidates under patent protection would be reduced. Without patent protection for our product candidates, we may be open to competition from biosimilar versions of our product candidates.

#### Third-party claims of intellectual property infringement against us or our collaborators may prevent or delay our product discovery and development efforts.
Our commercial success depends in part on our avoiding infringement of the patents and proprietary rights of third parties. There is a substantial amount of litigation involving patents and other intellectual property rights in the biotechnology and pharmaceutical industries, as well as administrative proceedings for challenging patents, including interference, derivation, and reexamination proceedings before the USPTO or oppositions and other comparable proceedings in foreign jurisdictions. Recently, due to changes in U.S. law referred to as patent reform, new procedures including *inter partes* review and post-grant review have been implemented. This reform adds uncertainty to the possibility of challenge to our patents in the future.

Numerous U.S. and foreign issued patents and pending patent applications owned by third parties exist in the fields in which we are developing our product candidates. As the biotechnology and pharmaceutical industries expand and more patents are issued, the risk increases that our product candidates may give rise to claims of infringement of the patent rights of others.

Although we have conducted analyses of the patent landscape with respect to our product candidates, and based on these analyses, we believe that we will be able to commercialize our product candidates, third parties may nonetheless assert that we infringe their patents, or that we are otherwise employing their proprietary technology without authorization, and may sue us. There may be third-party patents of which we are currently unaware with claims to compositions, formulations, methods of manufacture, or methods of use or treatment that cover our product candidates. Because patent applications can take many years to issue, there may be currently pending patent applications that may later result in issued patents that our product candidates may infringe. In addition, third parties may obtain patents in the future and claim that use of our technologies or the manufacture, use, or sale of our product candidates infringes

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upon these patents. If any such third-party patents were held by a court of competent jurisdiction to cover our technologies or product candidates, the holders of any such patents may be able to block our ability to commercialize the applicable drug product candidate unless we obtain a license under the applicable patents, or until such patents expire or are finally determined to be held invalid or unenforceable. Such a license may not be available on commercially reasonable terms or at all. If we are unable to obtain a necessary license to a third-party patent on commercially reasonable terms, our ability to commercialize our product candidates may be impaired or delayed, which could in turn significantly harm our business.

Third parties asserting their patent rights against us may seek and obtain injunctive or other equitable relief, which could effectively block our ability to further develop and commercialize our product candidates. Defense of these claims, regardless of their merit, would involve substantial litigation expense and would be a substantial diversion of management and other employee resources from our business, and may impact our reputation. In the event of a successful claim of infringement against us, we may have to pay substantial damages, including treble damages and attorneys' fees for willful infringement, obtain one or more licenses from third parties, pay royalties, or redesign our infringing products, which may be impossible or require substantial time and monetary expenditure. In that event, we would be unable to further develop and commercialize our product candidates, which could harm our business significantly.

Some of our competitors may be able to sustain the costs of complex patent litigation more effectively than we can because they have substantially greater resources. In addition, any uncertainties resulting from the initiation and continuation of any litigation could have a material adverse effect on our ability to raise the funds necessary to continue our operations or could otherwise have a material adverse effect on our business, results of operations, financial condition and prospects.

#### We may not be able to protect our intellectual property rights throughout the world.
Filing, prosecuting and defending patents on product candidates in all countries throughout the world would be prohibitively expensive. In addition, the laws of some foreign countries do not protect intellectual property rights to the same extent as laws in the EU or the United States. Consequently, we may not be able to prevent third parties from practicing our inventions in all countries, or from selling or importing products made using our inventions in and into other jurisdictions. Competitors may use our technologies in jurisdictions where we have not obtained patent protection to develop their own products and further, may export otherwise infringing products to territories where we have patent protection, but enforcement is not as strong. These products may compete with our products and our patents or other intellectual property rights may not be effective or sufficient to prevent them from competing.

Many companies have encountered significant problems in protecting and defending intellectual property rights in a number of jurisdictions. The legal systems of certain countries, particularly certain developing countries, do not favor the enforcement of patents, trade secrets and other intellectual property protection, particularly those relating to biotechnology products, which could make it difficult for us to stop the infringement of our patents or marketing of competing products in violation of our proprietary rights generally. Proceedings to enforce our patent rights in some jurisdictions could result in substantial costs and divert our efforts and attention from other aspects of our business, could put our patents at risk of being invalidated or interpreted narrowly and our patent applications at risk of not issuing and could provoke third parties to assert claims against us. We may not prevail in any lawsuits that we initiate, and the damages or other remedies awarded, if any, may not be commercially meaningful. Accordingly, our efforts to enforce our intellectual property rights around the world may be inadequate to obtain a significant commercial advantage from the intellectual property that we develop or license.

***We may be involved in lawsuits to protect or enforce our patents or the patents of our licensors, which could be expensive, time-consuming, and unsuccessful.***

Competitors may infringe our patents or the patents of our licensors. To address such infringement, we may be required to file patent infringement claims, which can be expensive and time-consuming. In addition, in an infringement proceeding or a declaratory judgment action against us, a court may decide that one or more of our patents is not valid or is unenforceable, or may refuse to stop the other party from using the technology at issue on the grounds that our patents do not cover the technology in question. An adverse result in any litigation or defense proceeding could put one or more of our or of our licensors' patents at risk of being invalidated, held unenforceable, interpreted narrowly,

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or amended such that they do not cover our product candidates. Such results could also increase the risk that pending patent applications of our or our licensors may not issue. Defense of these claims, regardless of their merit, would involve substantial litigation expense and could create a substantial diversion of employee resources from our business. Interference or derivation proceedings provoked by third parties may be necessary to determine the priority of inventions with respect to, or the correct inventorship of, our patents or patent applications or those of our licensors. An unfavorable outcome could result in a loss of our current patent rights and could require us to cease using the related technology or to attempt to license rights to it from the prevailing party. Our business could be harmed if the prevailing party does not offer us a license on commercially reasonable terms. Litigation, interference, or derivation proceedings may result in a decision adverse to our interests and, even if we are successful, may result in substantial costs and distract our management and other employees.

Furthermore, because of the substantial amount of discovery required in some jurisdictions in connection with intellectual property litigation, there is a risk that some of our confidential information could be compromised by disclosure during this type of litigation. In addition, there could be public announcements of the results of hearings, motions or other interim proceedings or developments. If securities analysts or investors perceive these results to be negative, it could have a substantial adverse effect on the price of our ordinary shares.

***Confidentiality agreements with employees and third parties may not prevent unauthorized disclosure of trade secrets and other proprietary information, and our inability to maintain the confidentiality of that information, due to unauthorized disclosure or use, or other event, could have a material adverse effect on our business.***

In addition to the protection afforded by patents, we seek to rely on trade secret protection and confidentiality agreements to protect proprietary know-how that is not patentable or that we elect not to patent, processes for which patents are difficult to enforce, and any other elements of our product discovery and development processes that involve proprietary know-how, information, or technology that is not covered by patents. Trade secrets, however, may be difficult to protect. We seek to protect our proprietary processes, in part, by entering into confidentiality agreements with our employees, consultants, outside scientific advisors, contractors and collaborators. Although we use reasonable efforts to protect our trade secrets, our employees, consultants, outside scientific advisors, contractors, and collaborators might intentionally or inadvertently disclose our trade secret information to competitors. In addition, competitors may otherwise gain access to our trade secrets or independently develop substantially equivalent information and techniques. Furthermore, the laws of some foreign countries do not protect proprietary rights to the same extent or in the same manner as the laws of the United States. As a result, we may encounter significant problems in protecting and defending our intellectual property both in the United States and abroad. If we are unable to prevent unauthorized material disclosure of our intellectual property to third parties, or misappropriation of our intellectual property by third parties, we will not be able to establish or maintain a competitive advantage in our market, which could materially adversely affect our business, operating results and financial condition.

#### We are increasingly dependent on information technology systems and our systems and infrastructure face the risk of cyber-attacks, theft, tampering or other intrusions.
Our intellectual property and other sensitive company information are dependent on sophisticated information technology systems and are potentially vulnerable to cyber-attack, viruses, misappropriation, or misuse by authorized individuals. A variety of important processes relating to the research & development, clinical operations and production of our products depend heavily on our information systems, including on premises systems, cloud-based systems, or systems of third-party providers to whom we outsource certain business functions, including the storage and transfer of critical, confidential, sensitive, or personal information regarding clinical trial subjects, employees and others.

If our data systems are compromised, our business operations may be impaired, we may lose profitable opportunities, or the value of those opportunities may be diminished, and we may lose value or revenue because of unlicensed use of our intellectual property or confidential or proprietary information.

If personal information of our employees or clinical subjects is misappropriated, our reputation may be injured resulting in loss of business and/or morale, and we may incur costs to remediate possible injury to those individuals or be required to pay fines or take other action with respect to judicial or regulatory actions arising out of such incidents.

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Data privacy or security breaches by employees and individuals with permitted access to our systems, including in some cases third-party service providers to which we may outsource certain business functions, may also pose a risk that sensitive data, including intellectual property or personal information, will be exposed to unauthorized persons or to the public.

Cyber-attacks are increasing in frequency, sophistication, and intensity, and opportunistically in response to the implementation of remote working arrangements in the context of COVID-19. These cyber-attacks are made by groups and individuals with a wide range of expertise and motives (including, but not limited to, industrial espionage). Cyber-attacks could include the deployment of harmful malware, denial of service attacks, worms, social engineering, including phishing, smishing, vishing, impersonation, and other means to collect user credentials, access systems, affect service reliability and threaten data confidentiality, integrity, and availability.

Cyber-attacks could significantly impact the availability of data systems that are essential to conducting routine business operations across the company, including product manufacturing or clinical development, and the recovery efforts could be time consuming and costly.

The development and maintenance of systems to safeguard against such attacks is costly and requires ongoing monitoring and updating as technologies change and efforts to overcome security measures become increasingly more sophisticated. Moreover, the costs related to these security measures are expected to continue to increase.

While we have invested to protect our data and other information and continue to upgrade and enhance our systems to keep pace with continuing changes in information processing technology, the possibility of a future data compromise cannot be eliminated entirely, and risks associated with intrusion, exposure, tampering, and theft remain. With respect to attack vectors that are currently unknown, the risk that our defenses are inadequate is significant.

Although we have not, to date, detected any material breaches of our information technology systems, data systems or personal information, the risk of such breaches remains and cannot be completely negated.

#### Issued patents covering our potential future product candidates could be found invalid or unenforceable if challenged in court or before relevant authority.
If we or one of our licensing partners initiate legal proceedings against a third party to enforce a patent covering one of our product candidates, the defendant could counterclaim that the patent covering our drug product candidate is invalid or unenforceable. Third parties may also raise similar claims before administrative bodies, even outside the context of litigation. Such mechanisms include re-examination, *inter partes* review, post grant review, oppositions and derivation proceedings. Such proceedings could result in revocation or amendment to our or those of our licensing partners' patents in such a way that the patent no longer covers and protects the relevant drug product candidate(s). The outcome following legal assertions of invalidity and unenforceability is unpredictable. With respect to the validity of our patents, for example, we cannot be certain that there is no invalidating prior art of which we, our patent counsel, and the patent examiner were unaware during prosecution. If a defendant were to prevail on a legal assertion of invalidity and/or unenforceability, we would lose at least part, and perhaps all, of the patent protection on our product candidates. Such a loss of patent protection could have a material adverse impact on our business.

#### Changes in U.S. and foreign patent law could diminish the value of patents in general, thereby impairing our ability to protect our products.
As is the case with other biopharmaceutical companies, our success is heavily dependent on intellectual property, particularly patents. Obtaining and enforcing patents in the biopharmaceutical industry involves, both technological and legal complexity, and is therefore costly, time-consuming, and inherently uncertain. Numerous recent changes to the patent laws and proposed changes to the rules of the USPTO may have a significant impact on our ability to protect our technology and enforce our intellectual property rights. For example, the Leahy-Smith America Invents Act, or AIA, enacted in 2011 involves significant changes in patent legislation. An important change introduced by the AIA is that, as of March 16, 2013, the United States transitioned to a ''first-to-file'' system for deciding which party should be granted a patent when two or more patent applications are filed by different parties claiming the same invention. A third party that files a patent application with the USPTO after that date but before us could therefore be awarded a patent covering an invention of ours even if we had made the invention before it was made by the third party. This will require us to be cognizant going forward of the time from invention to filing of a patent application.

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Among some of the other changes introduced by the AIA are changes that limit where a patentee may file a patent infringement suit and provide opportunities for third parties to challenge any issued patent in the USPTO. This applies to all of our U.S. patents, even those issued before March 16, 2013. Because of a lower evidentiary standard in USPTO proceedings compared to the evidentiary standard in United States federal court necessary to invalidate a patent claim, a third party could potentially provide evidence in a USPTO proceeding sufficient for the USPTO to hold a claim invalid even though the same evidence would be insufficient to invalidate the claim if first presented in a district court action. Accordingly, a third party may attempt to use the USPTO procedures to invalidate our patent claims that would not have been invalidated if first challenged by the third party as a defendant in a district court action.

In addition, recent court rulings in cases such as *Association for Molecular Pathology v. Myriad Genetics, Inc.* (Myriad I); *BRCA1- & BRCA2-Based Hereditary Cancer Test Patent Litig.* (Myriad II); and *Promega Corp. v. Life Technologies Corp.* have narrowed the scope of patent protection available in certain circumstances and weakened the rights of patent owners in certain situations. In addition to increasing uncertainty with regard to our ability to obtain patents in the future, this combination of events has created uncertainty with respect to the value of patents once obtained. Depending on decisions by the U.S. Congress, the federal courts, and the USPTO, the laws and regulations governing patents could change in unpredictable ways that would weaken our ability to obtain new patents or to enforce our existing patents and patents that we might obtain in the future. For example, in *Assoc. for Molecular Pathology v. Myriad Genetics, Inc.*, the U.S. Supreme Court held that certain claims to naturally-occurring substances are not patentable. Although we do not believe that any of the patents owned or licensed by us will be found invalid based on this decision, we cannot predict how future decisions by the courts, the U.S. Congress, or the USPTO may impact the value of our patents.

Our European patents and patent applications could be challenged in the recently created Unified Patent Court (UPC) for the European Union, that is expected to be fully ratified in 2023. We may decide to opt out our European patents and patent applications from the UPC. However, if certain formalities and requirements are not met, our European patents and patent applications could be challenged for non-compliance and brought under the jurisdiction of the UPC. We cannot be certain that our European patents and patent applications will avoid falling under the jurisdiction of the UPC, if we decide to opt out of the UPC. Under the UPC, a granted European patent would be valid and enforceable in numerous European countries. A successful invalidity challenge to a European patent under the UPC would result in loss of patent protection in those European countries. Accordingly, a single proceeding under the UPC could result in the partial or complete loss of patent protection in numerous European countries, rather than in each validated European country separately as such patents always have been adjudicated. Such a loss of patent protection could have a material adverse impact on our business and our ability to commercialize our technology and product candidates and, resultantly, on our business, financial condition, prospects and results of operations.

#### We have limited foreign intellectual property rights and may not be able to protect our intellectual property rights throughout the world.
Certain of our key patent families have been filed in the United States; however, we have less robust intellectual property rights outside the United States, and, in particular, we may not be able to pursue patent coverage of our product candidates in certain countries outside of the United States. Filing, prosecuting and defending patents on product candidates in all countries throughout the world would be prohibitively expensive, and our intellectual property rights in some countries outside the United States may be less extensive than those in the United States. In addition, the laws of some foreign countries do not protect intellectual property rights to the same extent as federal and state laws in the United States. The breadth and strength of our patents issued in foreign jurisdictions or regions may not be the same as the corresponding patents issued in the United States. Consequently, we may not be able to prevent third parties from practicing our inventions in all countries outside the United States, or from selling or importing products made using our inventions in and into the United States or other jurisdictions. Competitors may use our technologies in jurisdictions where we have not obtained patent protection to develop their own products and further, may export otherwise infringing products to certain territories where we have patent protection, but enforcement is not as strong as that in the United States. These products may compete with our products and our patents or other intellectual property rights may not be effective or sufficient to prevent them from competing. Most of our patent portfolio is at the very early stage. We will need to decide whether and in which jurisdictions to pursue protection for the various inventions in our portfolio prior to applicable deadlines.

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Many companies have encountered significant problems in protecting and defending intellectual property rights in foreign jurisdictions. The legal systems of certain countries, particularly certain developing countries, do not favor the enforcement of patents, trade secrets and other intellectual property protections, particularly those relating to drug and biopharmaceutical products. This difficulty with enforcing patents could make it difficult for us to stop the infringement of our patents or marketing of competing products otherwise generally in violation of our proprietary rights. Proceedings to enforce our patent rights in foreign jurisdictions could result in substantial costs and divert our efforts and attention from other aspects of our business, could put our patents at risk of being invalidated or interpreted narrowly, put our patent applications at risk of not issuing and could provoke third parties to assert claims against us. We may not prevail in any lawsuits that we initiate and the damages or other remedies awarded, if any, may not be commercially meaningful. Accordingly, our efforts to enforce our intellectual property rights around the world may be inadequate to obtain a significant commercial advantage from the intellectual property that we develop or license.

#### We may be subject to claims challenging the inventorship or ownership of our patents and other intellectual property.
We generally enter into confidentiality and intellectual property assignment agreements with our employees, consultants, and contractors. These agreements generally provide that inventions conceived by the party in the course of rendering services to us will be our exclusive property. However, those agreements may not be honored and may not effectively assign intellectual property rights to us. Moreover, there may be some circumstances, where we are unable to negotiate for such ownership rights. Disputes regarding ownership or inventorship of intellectual property can also arise in other contexts, such as collaborations and sponsored research. If we are subject to a dispute challenging our rights in or to patents or other intellectual property, such a dispute could be expensive and time-consuming. If we were unsuccessful, we could lose valuable rights in intellectual property that we regard as our own.

The intellectual property landscape around our potential product candidates is crowded, and third parties may initiate legal proceedings alleging that we are infringing, misappropriating, or otherwise violating their intellectual property rights, the outcome of which would be uncertain and could have a material adverse effect on the success of our business. We are aware of certain third-party patents and third-party patent applications in this landscape that may, if issued as patents, be asserted to encompass our technology.

#### We may be subject to claims that our employees, consultants, or independent contractors have wrongfully used or disclosed confidential information of third parties.
We have received confidential and proprietary information from third parties. In addition, we employ individuals who were previously employed at other biotechnology or pharmaceutical companies. We may be subject to claims that we or our employees, consultants, or independent contractors have inadvertently or otherwise used or disclosed confidential information of these third parties or our employees' former employers. Litigation may be necessary to defend against these claims. Even if we are successful in defending against these claims, litigation could result in substantial cost and be a distraction to our management and employees.

***We may be subject to damages resulting from claims that we or our employees have wrongfully used or disclosed alleged trade secrets of our competitors or are in breach of non-competition or non-solicitation agreements with our competitors.***

Many of our employees were previously employed at other biotechnology and pharmaceutical companies, including our competitors or potential competitors, in some cases until recently. We may be subject to claims that we or our employees have inadvertently or otherwise used or disclosed trade secrets or other proprietary information of these former employers or competitors. In addition, we may in the future be subject to claims that we caused an employee to breach the terms of his or her non-competition or non-solicitation agreement. Litigation may be necessary to defend against these claims. Even if we are successful in defending against these claims, litigation could result in substantial costs and could be a distraction to management. If our defense to those claims fails, in addition to paying monetary damages, we may lose valuable intellectual property rights or personnel. Any litigation or the threat thereof may adversely affect our ability to hire employees. A loss of key personnel or their work product could hamper or prevent our ability to commercialize product candidates, which could have an adverse effect on our business, financial condition and results of operations.

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#### If we do not obtain patent term extension and data exclusivity for any product candidates, our business may be materially harmed.
Depending upon the timing, duration and specifics of any FDA marketing approval of any potential future product candidates, one or more of our U.S. patents may be eligible for limited patent term extension under the Drug Price Competition and Patent Term Restoration Act of 1984, or the Hatch-Waxman Amendments. The Hatch-Waxman Amendments permit a patent extension term of up to five years as compensation for patent term lost during the FDA regulatory review process. A patent term extension cannot extend the remaining term of a patent beyond a total of 14 years from the date of product approval, only one patent may be extended and only those claims covering the approved drug, a method for using it, or a method for manufacturing it may be extended. However, we may not be granted an extension because of, for example, failing to exercise due diligence during the testing phase or regulatory review process, failing to apply for a patent extension within applicable deadlines, failing to apply prior to expiration of relevant patents, or otherwise failing to satisfy applicable requirements. Moreover, the applicable time period or the scope of patent protection afforded could be less than we request. If we are unable to obtain patent term extension or the term of any such extension is less than we believe we are entitled to, our competitors may obtain approval of competing products sooner than we would expect, and our business, financial condition, results of operations, and prospects could be materially harmed.

#### Risks Related to Our Organization, Structure and Operation
***Our licensing partners are subject to high standards of manufacturing in accordance with cGMPs and other manufacturing regulations. Complying with these requirements will require them to expend significant time, money and effort and any failure to comply could have an adverse effect on our business.***

Our current or future licensing partners must continuously adhere to cGMPs and corresponding manufacturing regulations of Competent Authorities. In complying with these regulations, our licensing partners must expend significant time, money and effort in the areas of design and development, testing, production, record-keeping and quality control to assure that the products meet applicable specifications and other regulatory requirements. Their failure to comply with these requirements could result in an enforcement action against them, including the seizure of products and shutting down of production. Our licensing partners may also be subject to audits by the Competent Authorities. If any of our licensing partners fail to comply with cGMPs or other applicable manufacturing regulations, our ability to develop and commercialize the products could suffer significant interruptions, which could have an adverse effect on our business.

***We are highly dependent on our key personnel, and if we are not successful in attracting, motivating and retaining highly qualified personnel, we may not be able to successfully implement our business strategy.***

Our ability to compete in the highly competitive biotechnology and pharmaceutical industries depends upon our ability to attract, motivate and retain highly qualified managerial, scientific and medical personnel. We are highly dependent on members of our Executive Committee, and our scientific and medical personnel. The loss of the services of any members of our Executive Committee, other key employees, and other scientific and medical advisors, and our inability to find suitable replacements, could result in delays in product development and harm our business.

Competition for skilled personnel in the biotechnology and pharmaceutical industries is intense and the turnover rate can be high, which may limit our ability to hire and retain highly qualified personnel on acceptable terms or at all.

To induce valuable employees to remain with us, in addition to salary and cash incentives, we have provided warrants that vest over time. The value to employees of these equity grants that vest over time may be significantly affected by movements in our share price that are beyond our control, and may at any time be insufficient to counteract more lucrative offers from other companies. We do not maintain "key man" insurance policies on the lives of all of these individuals or the lives of any of our other employees.

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#### The improper conduct of employees, agents, contractors, consultants or collaborators could adversely affect our reputation and business, prospects, operating results, and financial condition.
We cannot ensure that our compliance controls, policies, and procedures will in every instance protect it from acts committed by our employees, agents, contractors, or collaborators that would violate the laws or regulations of the jurisdictions in which it operates, including, without limitation, healthcare, employment, foreign corrupt practices, environmental, competition, and patient privacy and other privacy laws and regulations. Such improper actions could subject us to civil or criminal investigations, and monetary and injunctive penalties, and could adversely impact our ability to conduct business, operating results, and reputation. In particular, our business activities may be subject to anti-bribery or anti-corruption laws, regulations or rules of countries in which it operates, including the Foreign Corrupt Practices Act, or FCPA, or the U.K. Bribery Act.

Violations of these laws and regulations could result in fines, criminal sanctions against us, our officers, or our employees, the closing down of our facilities, requirements to obtain export licenses, cessation of business activities in sanctioned countries, implementation of compliance programs, and prohibitions on the conduct of our business. Any such violations could include prohibitions on our ability to offer products in one or more countries and could materially damage our reputation, our brand, our international expansion efforts, our ability to attract and retain employees, and our business, prospects, operating results, and financial condition.

#### We have limited experience in sales, marketing and distribution.
Given our stage in development, we have never marketed a product and have therefore limited experience in the fields of sales, marketing and distribution of therapies. As a consequence, we will have to acquire marketing skills and develop our own sales and marketing infrastructure and would need to incur additional expenses, mobilize management resources, implement new skills and take the time necessary to set up the appropriate organization and structure to market the relevant product(s), in accordance with applicable laws.

While several of our managers have commercialized and launched high technology medical products there can be no assurance that the existing limited experience would be sufficient to effectively commercialize any or all of our product candidates. We may not be able to attract qualified sales and marketing personnel on acceptable terms in the future and therefore may experience constraints that will impede the achievement of our commercial objectives. Such events could have a material adverse effect on our business, prospects, financial situation, earnings and growth.

***If we engage in future acquisitions or strategic partnerships, this may increase our capital requirements, dilute our shareholders, and cause it to incur debt or assume contingent liabilities, and subject it to other risks.***

We may evaluate various acquisitions and strategic partnerships, including licensing or acquiring complementary products, intellectual property rights, technologies, or businesses. Any potential acquisition or strategic partnership may entail numerous risks, including:

• Increased operating expenses and cash requirements;

• The assumption of additional indebtedness or contingent liabilities;

• The issuance of our equity securities;

• Assimilation of operations, intellectual property and products of an acquired company, including difficulties associated with integrating new personnel;

• The diversion of our management's attention from our existing product programs and initiatives in pursuing such a strategic merger or acquisition;

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• Retention of key employees, the loss of key personnel, and uncertainties in our ability to maintain key business relationships;

• Risks and uncertainties associated with the other party to such a transaction, including the prospects of that party and their existing products or product candidates and regulatory approvals; and

• Our inability to generate revenue from acquired technology and/or products sufficient to meet our objectives in undertaking the acquisition or even to offset the associated acquisition and maintenance costs.

In addition, if we undertake acquisitions, we may issue dilutive securities, assume or incur debt obligations, incur large one-time expenses and acquire intangible assets that could result in significant future amortization expense. Moreover, we may not be able to locate suitable acquisition opportunities and this inability could impair our ability to grow or obtain access to technology or products that may be important to the development of our business.

#### We are subject to certain covenants as a result of certain non-dilutive financial support received to date.
We have received some non-dilutive financial supports from the Walloon Region to support various research programs. The support has been granted in the form of recoverable cash advances, or RCAs, and subsidies.

In the event we decide to exploit any discoveries or products from the research funded by under an RCA, the relevant RCA becomes refundable; otherwise, the RCA is not refundable. We own the intellectual property rights which result from the research programs partially funded by the Region, unless it decides not to exploit, or cease to exploit, the results of the research in which case the results and intellectual property rights are transferred to the Region. Subject to certain exceptions, however, we cannot grant to third parties, by way of license or otherwise, any right to use the results without the prior consent of the Region. We also need the consent of the Region to transfer an intellectual property right resulting from the research programs or a transfer or license of a prototype or installation. Obtaining such consent from the Region could give rise to a review of the applicable financial terms. The RCAs also contain provisions prohibiting us from conducting research for any other person which would fall within the scope of a research program of one of the RCAs. Most RCAs provide that this prohibition is applicable during the research phase and the decision phase, but a number of RCAs extend it beyond these phases.

Subsidies received from the Region are dedicated to funding research programs and patent applications and are not refundable. We own the intellectual property rights which result from the research programs or with regard to a patent covered by a subsidy. Subject to certain exceptions, however, we cannot grant to third parties, by way of license, transfer or otherwise, any right to use the patents or research results without the prior consent of the Region. In addition, certain subsidies require that we exploit the patent in the countries where the protection was granted and to make an industrial use of the underlying invention. In case of bankruptcy, liquidation or dissolution, the rights to the patents covered by the patent subsidies will be assumed by the Region by operation of law unless the subsidy is reimbursed. Furthermore, we would lose our qualification as a small or medium-sized enterprise, the patent subsidies will terminate, and no additional expenses will be covered by such patent subsidies. In 2022 and beyond, we will be required to make exploitation decisions on our remaining outstanding RCA related to the CAR T platform.

***Failure to build our finance infrastructure and improve our accounting systems and controls could impair our ability to comply with the financial reporting and internal controls requirements for publicly traded companies.***

As a public company, we are operating in an increasingly demanding regulatory environment that requires us to comply with, among other things, the Sarbanes-Oxley Act of 2002 and related rules and regulations of the Securities and Exchange Commission's substantial disclosure requirements, accelerated reporting requirements and complex accounting rules. Company responsibilities required by the Sarbanes-Oxley Act include establishing corporate oversight and adequate internal control over financial reporting and disclosure controls and procedures. Effective internal controls are necessary for us to produce reliable financial reports and are important to help prevent financial fraud.

Management identified no material weakness as of December 31, 2022. See "Item 15—Controls and Procedures" of this Annual Report for further discussion of management's assessment of the effectiveness of our internal control over financial reporting. Section 404 of the Sarbanes-Oxley Act requires that we include a report of management on our internal control over financial reporting in our Annual Report on Form 20-F.

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Assessing our procedures to improve our internal control over financial reporting is an ongoing process. We can provide no assurance that we will not have material weaknesses in the future. Any additional material weaknesses we identify could result in an adverse reaction in the financial markets due to a loss of confidence in the reliability of our consolidated financial statements. Any failure to maintain internal control over financial reporting could severely inhibit our ability to accurately report our financial condition, results of operations or cash flows. If we are unable to remedy the material weaknesses and continue to conclude that our internal control over financial reporting is ineffective, we could lose investor confidence in the accuracy and completeness of our financial reports, the market price of the ADSs could decline, and we could be subject to sanctions or investigations by the NASDAQ Stock Market, the SEC or other regulatory authorities. Failure to remedy any material weakness in our internal control over financial reporting, or to implement or maintain other effective control systems required of public companies, could also restrict our future access to the capital markets.

*We may not be able to maintain compliance with the continued listing requirements of NASDAQ, or may choose to delist from the NASDAQ Global Market, which could negatively affect the liquidity and trading prices of our ordinary shares.* 

Our ADSs are listed on the Nasdaq Global Market. In order to maintain that listing, we must satisfy minimum financial and other requirements including, without limitation, a requirement that our closing bid price must not fall below $1.00 per ADS for 30 consecutive business days. In the event that it was necessary to regain compliance with this closing bid price requirement, we would be permitted 180 days in which to do so and would need to demonstrate that we had maintained a closing bid price of a minimum of $1.00 per ADS for 10 consecutive business days. In the event that we were unable to regain compliance during this initial 180 day period, or a possible further 180 day period, we may need to implement reverse stock splits or change the ratio of ADSs to ordinary shares or take other measures in order to regain compliance with this closing bid price requirement. If we fail to continue to meet all applicable continued listing requirements for Nasdaq in the future and Nasdaq determines to delist our ADSs,

We may also consider voluntarily delisting our ADSs from the NASDAQ Stock Market by filing a Form 25 with the Securities and Exchange Commission. Therefore, our ADSs would be delisted from the NASDAQ Global Market. Following such delisting, we may also deregister our ADSs under the Exchange Act and become a non-reporting company under the Exchange Act by filing a Form 15, Notice of Termination of Registration and Suspension of Duty to File, to terminate its reporting obligations under the Exchange Act. If we were to file a Form 15, our obligation to file reports would be suspended. Delisting and deregistration of the Company's ADSs could negatively affect the liquidity and trading prices of our ordinary shares.

#### Our international operations subject it to various risks, and our failure to manage these risks could adversely affect our results of operations.
We face significant operational risks as a result of doing business internationally, such as:

• Fluctuations in foreign currency exchange rates;

• Potentially adverse and/or unexpected tax consequences, including penalties due to the failure of tax planning or due to the challenge by tax authorities on the basis of transfer pricing and liabilities imposed from inconsistent enforcement;

• Potential changes to the accounting standards, which may influence our financial situation and results;

• Becoming subject to the different, complex and changing laws, regulations and court systems of multiple jurisdictions and compliance with a wide variety of foreign laws, treaties and regulations (including those relating to corporate taxation and sales taxes);

• Reduced protection of, or significant difficulties in enforcing, intellectual property rights in certain countries;

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• Difficulties in attracting and retaining qualified personnel;

• Restrictions imposed by local labor practices and laws on our business and operations, including unilateral cancellation or modification of contracts; and

• Rapid changes in global government, economic and political policies and conditions, political or civil unrest or instability, terrorism or epidemics and other similar outbreaks or events, and potential failure in confidence of our suppliers or customers due to such changes or events; and tariffs, trade protection measures, import or export licensing requirements, trade embargoes and other trade barriers.

We incur portions of our expenses, and may in the future derive revenues, in currencies other than the euro, in particular, the U.S. dollar. As a result, we are exposed to foreign currency exchange risk as our results of operations and cash flows are subject to fluctuations in foreign currency exchange rates. We currently do not engage in hedging transactions to protect against uncertainty in future exchange rates between particular foreign currencies and the euro. Therefore, for example, an increase in the value of the euro against the U.S. dollar could be expected to have a negative impact on our revenue and earnings growth as U.S. dollar revenue and earnings, if any, would be translated into euros at a reduced value. We cannot predict the impact of foreign currency fluctuations, and foreign currency fluctuations in the future may adversely affect our financial condition, results of operations and cash flows.

***We or third parties upon whom we depend may be adversely affected by natural disasters and/or global health pandemics, and our business, financial condition and results of operations could be adversely affected.***

The occurrence of unforeseen or catastrophic events, including extreme weather events and other natural disasters, man-made disasters, or the emergence of epidemics or pandemics, depending on their scale, may cause different degrees of damage to the national and local economies and could cause a disruption in our operations and have a material adverse effect on our financial condition and results of operations. Man-made disasters, pandemics, and other events connected with the regions in which we operate could have similar effects. If a natural disaster, health pandemic, or other event beyond our control occurred that prevented us from using all or a significant portion of our office and/or lab spaces, damaged critical infrastructure, such as our manufacturing facilities or our manufacturing facilities of our third-party contract manufacturers, or that otherwise disrupted operations, it may be difficult for us to continue our business for a substantial period of time.

***Unsuccessful management of environmental, social and governance matters could adversely affect our reputation and we may experience difficulties to meet the expectations of our stakeholders.***

Companies are increasingly expected to behave in a responsible manner on a variety of environmental, social and governance (ESG) matters, by governmental and regulatory authorities, counterparties such as vendors and suppliers, customers, investors, the public at large and others. This context, driven in part by a rapidly changing regulatory framework, is raising new challenges and influencing strategic decisions that companies must take if they wish to optimize their positive impact and mitigate their negative impact on ESG matters. Furthermore, this increased focus on sustainability may result in new laws, regulations and requirements that could cause disruptions in or increased costs associated with our business.

We may be unable to meet the ever more demanding criteria used by rating agencies in their ESG assessments process, leading to a downgrading in our rating. Financial investments in companies which perform well in ESG assessments are increasingly popular, and major institutional investors have made known their interest in investing in such companies. Moreover, despite the voluntary nature of such efforts, we may receive pressure from external sources, such as lenders, investors or other groups, to adopt more aggressive climate or other ESG-related initiatives; however, we may not agree that such initiatives will be appropriate for our business, and we may not be able to implement such initiatives because of potential costs or technical or operational obstacles. Depending on ESG assessments and on the rapidly changing views on acceptable levels of action across a range of ESG topics from investors, we may be unable to meet society's or investors' expectations, our reputation may be harmed, we may face increased compliance or other costs and demand for securities issued by us and our ability to participate in the debt and equity markets may decrease.

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#### Risks Related to Our Financial Position and Need for Capital

#### We have incurred net losses in each period since our inception and anticipate that we will continue to incur net losses in the future.
We are not profitable and have incurred losses in each period since our inception. For the years ended December 31, 2022, 2021 and 2020, we incurred a loss for the year of €40.9 million, €26.5 million and €17.2 million, respectively. As of December 31, 2022, we had an accumulated deficit of €349.9 million. We expect this accumulated deficit to increase as we continue to incur significant research and development and other expenses related to our ongoing operations. Consequently, our net assets decreased and the Board of Directors was required to comply with the Article 7:228 of the Belgian Code on Companies and Associations from the date of our financial statements for the year ended December 31, 2022. Per Article 7:228, if a company's net assets have dropped below half of its share capital, then a shareholders' meeting must be convened within two months after the date on which such loss was (or should have been) determined, which will determine whether the company will continue to exist or be wound up. In March 2023, the Board of Directors acknowledged that our net assets have fallen below half of our share capital. We are therefore complying with the Article 7:228, and a shareholders' meeting shall be convened within two months from the date of this annual report in order to decide on our continuity or winding up. We can provide no assurance that shareholders will approve our proposal to continue operations that we plan to put forth at this meeting.

Our main assets are intellectual property rights concerning technologies that have not led to commercialization of any product. We have never been profitable and have never commercialized any products.

Even if we succeed in commercializing one or more of any future product candidates, we will continue to incur losses for the foreseeable future relating to our substantial research and development expenditures to develop our technologies. We anticipate that our expenses will increase substantially if and as we:

• Commence and perform research and development and related regulatory activities for any future product candidates;

• Initiate preclinical studies of any new product candidates;

• Make milestone or other payments under any in-license agreements;

• Maintain, protect and expand our intellectual property portfolio; and

• Maintain and upgrade internal controls.

We may encounter unforeseen expenses, difficulties, complications, delays and other unknown factors that may adversely affect our business. The size of our future net losses will depend, in part, on the rate of future growth of our expenses and our ability to generate revenue.

Our prior losses and expected future losses have had and will continue to have an adverse effect on our shareholders' equity and working capital. Further, the net losses we incur may fluctuate significantly from quarter to quarter and year to year, such that a period-to-period comparison of our results of operations may not be a good indication of our future performance.

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#### We may need substantial additional funding, which may not be available on acceptable terms when needed, if at all.
Our operations have required substantial amounts of cash since inception. In 2022, we decided implemented a strategic shift from an organization focused on clinical development to one prioritizing R&D discovery and the monetization of its intellectual property (IP) portfolio through partnerships, collaborations and license agreements. In that framework, we decided to discontinue the clinical development of our product candidates, including our clinical trials for CYAD-211, CYAD-101 and CYAD-02. We expect to continue spending substantial amounts to implement our activities.

As of December 31, 2022, the Company had cash and cash equivalents of €12.4 million and no short-term investments.

Based on our current scope of activities, we estimates that our cash and cash equivalents as of December 31, 2022 should be sufficient to fund operating expenses and capital expenditure requirements into the fourth quarter of 2023.

However, changing circumstances may cause us to increase our spending significantly faster than we currently anticipate, and we may need to spend more money than currently expected because of circumstances beyond our control.

The achievement of milestones (R&D, scientific, clinical, regulatory, business) will trigger payment obligations towards Celdara, Dartmouth and Horizon, which will negatively impact our profitability and may require material additional funding.

We contracted over the past year numerous funding agreements with the Walloon Region to partially finance its research and development programs. Under the terms of the agreements, we would need to obtain the consent of the Walloon Region for any out-licensing agreement or sale to a third party of any or all of our products, prototypes or installations which may reduce our ability to partner or sell part or all of our products.

We may not be able to reimburse such funding under the terms of the agreements or such reimbursement may jeopardize the funding of our clinical and scientific activities

Our ability to raise additional funds will depend on financial, economic and market conditions and other factors, over which we may have no or limited control, including the current geopolitical tension and military conflict between Russia and Ukraine, and we cannot guarantee that additional funds will be available to it when necessary, on commercially acceptable terms, if at all. If the necessary funds are not available, we may need to seek funds through collaborations and licensing arrangements, which may require us to reduce or relinquish significant rights to our research programs and product candidates, to grant licenses on our technologies to partners or third parties or enter into new collaboration agreements, the terms could be less favorable to us than those we might have obtained in a different context. If adequate funds are not available on commercially acceptable terms when needed, we may be forced to delay, reduce or terminate the development or commercialization of all or part of our research programs or product candidates or we may be unable to take advantage of future business opportunities.

#### Our net losses and significant cash used in operating activities have raised doubt regarding our ability to continue as a going concern.
We have a limited operating history and have experienced net losses and significant cash used in operating activities in each period since inception. We expect to continue to incur net losses and have significant cash outflows for at least the next year. As of December 31, 2022, we had cash and cash equivalents of €12.4 million and no short-term investments and an accumulated deficit of €349.9 million.

Our cash and cash equivalents and accumulated deficit, among other factors, raise doubt about our ability to continue as a going concern. Our inability to continue as a going concern could materially limit our ability to raise additional funds through the issuance of new debt or equity securities or otherwise. Future reports on our financial statements may also include an explanatory paragraph with respect to our ability to continue as a going concern. We have not been profitable since inception, and it is possible we will never achieve profitability. There is no substantial source of revenues, much less profits, to sustain our present activities, and there can be no assurance as to when substantial revenues will likely be available, an outcome which may not occur.

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Based on our current level of operating expenditures, we expect our cash position as of December 31, 2022, to be able to fund our operations into the fourth quarter of 2023 but we will require significant additional cash resources to launch new development phases of existing projects in our pipeline. In addition, this period could be shortened if there are any significant increases in planned spending on development programs or more rapid progress of development programs than anticipated. Other financing may not be available when needed to allow us to continue as a going concern. The perception that we may not be able to continue as a going concern may cause others to choose not to deal with us due to concerns about our ability to meet our contractual obligations.

***Raising additional capital may cause dilution to our existing shareholders, restrict our operations or require us to relinquish rights to our product candidates or technologies.***

We may seek additional funding through a combination of equity offerings, debt financings, collaborations and/or licensing arrangements. To the extent that we raise additional capital through the sale of equity or convertible debt securities, the shareholders will be diluted, and the terms may include liquidation or other preferences that adversely affect your rights as a shareholder. The incurrence of indebtedness and/or the issuance of certain equity securities could result in increased fixed payment obligations and could also result in certain additional restrictive covenants, such as limitations on our ability to incur additional debt and/or issue additional equity, limitations on our ability to acquire or license intellectual property rights and other operating restrictions that could adversely impact our ability to conduct our business. In addition, issuance of additional equity securities, or the possibility of such issuance, may cause the market price of the Shares to decline. In the event that we enter into collaborations and/or licensing arrangements in order to raise capital, it may be required to accept unfavorable terms, including relinquishing or licensing to a third party on unfavorable terms our rights to technologies or product candidates that we otherwise would seek to develop or commercialize ourselves or potentially reserve for future potential arrangements when we might be able to achieve more favorable terms.

#### We may be exposed to significant foreign exchange risk.
We incur portions of our expenses, and may in the future derive revenues, in currencies other than the euro, in particular, the U.S. dollar. As a result, we are exposed to foreign currency exchange risk as our results of operations and cash flows are subject to fluctuations in foreign currency exchange rates. We currently do not engage in hedging transactions to protect against uncertainty in future exchange rates between particular foreign currencies and the euro. Therefore, for example, an increase in the value of the euro against the U.S. dollar could be expected to have a negative impact on our revenue and earnings growth as U.S. dollar revenue and earnings, if any, would be translated into euros at a reduced value.

#### The investment of our cash and cash equivalents may be subject to risks that may cause losses and affect the liquidity of these investments.
As of December 31, 2022, we had cash and cash equivalents of €12.4 million and no short-term investments. We historically have invested substantially all of our available cash and cash equivalents in corporate bank accounts. Pending their use in our business, we may invest the net proceeds of our global offerings in investments that may include corporate bonds, commercial paper, certificates of deposit and money market funds. These investments may be subject to general credit, liquidity, and market and interest rate risks. We may realize losses in the fair value of these investments or a complete loss of these investments, which would have a negative effect on our financial statements.

#### Risks Related to Ownership of Our Ordinary Shares and American Depositary Shares ("ADS")
***If securities or industry analysts do not publish research or publish inaccurate research or unfavorable research about our business, the price of the ordinary shares and the ADSs and trading volume could decline.***

The trading market for the ordinary shares and the ADSs depends in part on the research and reports that securities or industry analysts publish about us or our business. If no or few securities or industry analysts cover our company, the trading price for the ordinary shares and the ADSs would be negatively impacted. If one or more of the analysts who covers us downgrades the ordinary shares or the ADSs or publishes incorrect or unfavorable research about our business, the price of the ordinary shares and the ADSs would likely decline. If one or more of these analysts ceases coverage of our company or fails to publish reports on us regularly, or downgrades the ordinary shares or the ADSs, demand for the ADSs and ordinary shares could decrease, which could cause the price of the ADSs and ordinary shares or trading volume to decline.

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#### The market price of the shares could be negatively impacted by actual or anticipated sales of substantial numbers of ordinary shares or ADSs.
Sales of a substantial number of Shares in the public markets, or the perception that such sales might occur, might cause the market price of the Shares to decline. We cannot make any prediction as to the effect of any such sales or perception of potential sales on the market price of the Shares.

#### A public market for our shares may not be sustained.
We cannot guarantee the extent to which a liquid market for our ordinary shares or ADSs will be sustained. In the absence of such liquid market for our ordinary shares or ADSs, the price of our ordinary shares or ADSs could be influenced. The liquidity of the market for our ordinary shares or ADSs could be affected by various causes, including the factors identified in the next risk factor (below) or by a reduced interest of investors in biotechnology sector.

#### The market price of the shares may fluctuate widely in response to various factors.
A number of factors may significantly affect the market price of our ordinary shares or ADSs. The main factors are changes in our operating results and those of our competitors, announcements of technological innovations or results concerning our product candidates, changes in earnings estimates by analysts.

Other factors which could cause the price of the shares to fluctuate or could influence our reputation include, amongst other things:

• Public information regarding actual or potential results relating to products and product candidates under development by our competitors;

• Actual or potential results relating to our product candidates;

• Developments concerning intellectual property rights, including patents;

• Regulatory and medicine pricing and reimbursement developments in Europe, the United States and other jurisdictions;

• Any publicity derived from any business affairs, contingencies, litigation or other proceedings, our assets (including the imposition of any lien), our management, or our significant shareholders or collaborative partners;

• Divergences in financial results from stock market expectations;

• Changes in the general conditions in the pharmaceutical industry and general economic, financial market and business conditions in the countries in which we operate; and

• Any publicity derived from data protection or cybersecurity breaches.

In addition, stock markets have from time-to-time experienced extreme price and volume volatility which, in addition to general economic, financial and political conditions, could affect the market price for the Shares regardless of the operating results or our financial condition. The stock market in general and the market for biopharmaceutical companies in particular have experienced extreme volatility that can often been unrelated to the operating performance of particular companies.

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***We have no present intention to pay dividends on our ordinary shares in the foreseeable future and, consequently, your only opportunity to achieve a return on your investment during that time is if the price of the securities increases.***

We have no present intention to pay dividends in the foreseeable future. Any recommendation by our Board of Directors to pay dividends will depend on many factors, including our financial condition (including losses carried-forward), results of operations, legal requirements and other factors. Furthermore, pursuant to Belgian law, the calculation of amounts available for distribution to shareholders, as dividends or otherwise, must be determined on the basis of our non-consolidated statutory accounts prepared in accordance with Belgian accounting rules. In addition, in accordance with Belgian law and our Articles of Association, we must allocate each year an amount of at least 5% of our annual net profit under our non-consolidated statutory accounts to a legal reserve until the reserve equals 10% of our share capital. Therefore, we are unlikely to pay dividends or other distributions in the foreseeable future. If the price of the securities or the underlying ordinary shares declines before we pay dividends, investors will incur a loss on their investment, without the likelihood that this loss will be offset in part or at all by potential future cash dividends.

#### Takeover provisions in the national law of Belgium may make a takeover difficult.
Public takeover bids on our shares and other voting securities, such as warrants or convertible bonds, if any, are subject to the Belgian Act of 1 April 2007 on public takeover bids, as amended and implemented by the Belgian Royal Decree of April 27, 2007, or Royal Decree, and to the supervision by the Belgian Financial Services and Markets Authority, or FSMA. Public takeover bids must be made for all of our voting securities, as well as for all other securities that entitle the holders thereof to the subscription to, the acquisition of or the conversion into voting securities. Prior to making a bid, a bidder must issue and disseminate a prospectus, which must be approved by the FSMA. The bidder must also obtain approval of the relevant competition authorities, where such approval is legally required for the acquisition of us. The Belgian Act of 1 April 2007 provides that a mandatory bid will be required to be launched for all of our outstanding shares and securities giving access to ordinary shares if a person, as a result of our own acquisition or the acquisition by persons acting in concert with it or by persons acting on their account, directly or indirectly holds more than 30% of the voting securities in a company that has our registered office in Belgium and of which at least part of the voting securities are traded on a regulated market or on a multilateral trading facility designated by the Royal Decree. The mere fact of exceeding the relevant threshold through the acquisition of one or more shares will give rise to a mandatory bid, irrespective of whether or not the price paid in the relevant transaction exceeds the current market price.

There are several provisions of Belgian company law and certain other provisions of Belgian law, such as the obligation to disclose important shareholdings and merger control, which may apply to us and which may make an unfriendly tender offer, merger, change in management or other change in control, more difficult. These provisions could discourage potential takeover attempts that third parties may consider and thus deprive the shareholders of the opportunity to sell their shares at a premium (which is typically offered in the framework of a takeover bid).

#### We may be at an increased risk of securities class action litigation.
Historically, securities class action litigation has often been brought against a company following a decline in the market price of that company's securities. This risk is especially relevant for us because biotechnology and biopharmaceutical companies have experienced significant share price volatility in recent years. If we were to be sued, it could result in substantial costs and a diversion of management's attention and resources, which could harm our business.

#### Holders of the shares outside Belgium and France may not be able to exercise pre-emption rights (notice for non-Belgian resident investors).
In the event of an increase in our share capital in cash, holders of shares are generally entitled to full pre-emption rights unless these rights are excluded or limited either by a resolution of the general meeting, or by a resolution of the Board of Directors (if the Board of Directors has been authorized by the general meeting in the articles of association to increase the share capital in that manner). Certain holders of shares outside Belgium or France may not be able to exercise pre-emption rights unless local securities laws have been complied with. In particular, U.S. holders of the shares may not be able to exercise pre-emption rights unless a registration statement under the Securities Act is declared effective with respect to the shares issuable upon exercise of such rights or an exemption from the registration requirements is available. We do not intend to obtain a registration statement in the U.S. or to fulfil any requirement in other jurisdictions (other than Belgium and France) in order to allow shareholders in such jurisdictions to exercise their pre-emptive rights (to the extent not excluded or limited).

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#### We have been subject to an investigation by the Belgian Financial Services and Markets Authority.
The Belgian Financial Services and Markets Authority, or the FSMA, opened an investigation against us on April 22, 2014. Such investigation was related to whether we had failed to timely disclose inside information to the market in relation to the Investigational New Drug, or IND, clearance from the FDA for our CHART-2 Phase III heart-failure trial received on December 26, 2013, and reported on January 9, 2014. In April 2015, we notified the FSMA our agreement to settle our investigation by paying the proposed settlement amount of €175,000. Although such settlement does not provide for any admission of guilt on our part, the fact that we have entered into a settlement with the FSMA could cause investors to have a negative perception of our governance structure, which would have a material adverse effect on our business. Further, any future allegations (based on other facts and circumstances) that we failed to comply with applicable securities laws, whether or not true, may subject it to fines, claims and/or sanctions, which could impair our ability to offer our securities or restrict trading in our securities. The occurrence of any of the foregoing could have a material adverse effect on the trading price of our securities and our business.

#### Fluctuations in the exchange rate between the U.S. dollar and the euro may increase the risk of holding the ADSs.
Our ordinary shares currently trade on Euronext Brussels and Euronext Paris in euros, while the ADSs trade on NASDAQ in U.S. dollars. Fluctuations in the exchange rate between the U.S. dollar and the euro may result in differences between the value of the ADSs and the value of our ordinary shares, which may result in heavy trading by investors seeking to exploit such differences. In addition, as a result of fluctuations in the exchange rate between the U.S. dollar and the euro, the U.S. dollar equivalent of the proceeds that a holder of the ADSs would receive upon the sale in Belgium of any ordinary shares withdrawn from the depositary upon calculation of the corresponding ADSs and the U.S. dollar equivalent of any cash dividends paid in euros on our ordinary shares represented by the ADSs could also decline.

#### Holders of the ADSs are not treated as shareholders of our company.
Holders of the ADSs are not treated as shareholders of our company, unless they cancel the ADSs and withdraw our ordinary shares underlying the ADSs. The depositary (or its nominee) is the shareholder of the ordinary shares underlying the ADSs. Holders of ADSs therefore do not have any rights as shareholders of our company, other than the rights that they have pursuant to the deposit agreement.

***Our shareholders residing in countries other than Belgium may be subject to double withholding taxation with respect to dividends or other distributions made by us.***

Any dividends or other distributions we make to shareholders will, in principle, be subject to withholding tax in Belgium at a rate of 30%, except for shareholders which qualify for an exemption of withholding tax such as, among others, qualifying pension funds or a company qualifying as a parent company within the meaning of the Council Directive (90/435/EEC) July 23, 1990, known as the Parent-Subsidiary Directive, or that qualify for a lower withholding tax rate or an exemption by virtue of a tax treaty. Various conditions may apply and shareholders residing in countries other than Belgium are advised to consult their advisers regarding the tax consequences of dividends or other distributions made by us. Our shareholders residing in countries other than Belgium may not be able to credit the amount of such withholding tax to any tax due on such dividends or other distributions in any other country than Belgium. As a result, such shareholders may be subject to double taxation in respect of such dividends or other distributions. Belgium and the United States have concluded a double tax treaty concerning the avoidance of double taxation, or the U.S.-Belgium Tax Treaty. The U.S.-Belgium Tax Treaty reduces the applicability of Belgian withholding tax to 15%, 5% or 0% for U.S. taxpayers, provided that the U.S. taxpayer meets the limitation of benefits conditions imposed by the U.S.-Belgium Tax Treaty. The Belgian withholding tax is generally reduced to 15% under the U.S.-Belgium Tax Treaty. The 5% withholding tax applies in case where the U.S. shareholder is a company which holds at least 10% of the shares in the company. A 0% Belgian withholding tax applies when the shareholder is a company which has held at least 10% of the shares for at least 12 months, or is, subject to certain conditions, a U.S. pension fund. The U.S. shareholders are encouraged to consult their own tax advisers to determine whether they can invoke the benefits and meet the limitation of benefits conditions as imposed by the U.S.-Belgium Tax Treaty.

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#### U.S. holders of the ADSs may suffer adverse tax consequences if we are characterized as a PFIC for any taxable year.
Generally, if, for any taxable year, at least 75% of our gross income is passive income, or at least 50% of the average quarterly value of our assets is attributable to assets that produce passive income or are held for the production of passive income, including cash, we would be characterized as a passive foreign investment company (PFIC), for U.S. federal income tax purposes. Passive income for this purpose generally includes dividends, interest, royalties, rents, gains from commodities and securities transactions, the excess of gains over losses from the disposition of assets which produce passive income, and includes amounts derived by reason of the temporary investment of cash, including the funds raised in offerings of the ADSs. If we are characterized as a PFIC, U.S. holders (as defined below under "Taxation – Material Income Tax Considerations – Certain Material U.S. Federal Income Tax Considerations to U.S. Holders") of the ADSs may suffer adverse tax consequences, including having gains realized on the sale of the ADSs treated as ordinary income, rather than capital gain, the loss of the preferential rate applicable to dividends received on the ADSs by individuals who are U.S. holders, and having interest charges apply to distributions by us and the proceeds of sales of the ADSs.

Based on our past and current projections of our income and assets, we do not expect to conclude that we were a PFIC for the taxable year ended December 31, 2022. A separate factual determination as to whether we are or have become a PFIC must be made each year (after the close of such year). For purposes of the PFIC asset test, the value of our assets will generally be determined by reference to our market capitalization. Since our projections may differ from our actual business results and our market capitalization and value of our assets may fluctuate substantially, we cannot assure you that we were not a PFIC for our taxable year ended December 31, 2022 and that we will not be or become a PFIC in the current taxable year or any future taxable year. Our status as a PFIC also depends on the interpretation of the rules governing the PFIC income and asset tests, which are subject to uncertainty (including with respect to the characterization of income from government grants, for which direct legal authority does not exist). Each U.S. holder is strongly urged to consult his, her or its tax advisor regarding the application of these rules and the availability of any potential elections.

#### Future sales of ordinary shares or ADSs by existing shareholders could depress the market price of the ADSs.
If our existing shareholders sell, or indicate an intent to sell, substantial amounts of ordinary shares or ADSs in the public market, the trading price of the ADSs could decline significantly. In the future we may file one or more registration statements with the SEC covering ordinary shares available for future issuance under our equity incentive plans. Upon effectiveness of such registration statements, any shares subsequently issued under such plans will be eligible for sale in the public market, except to the extent that they are restricted by the lock-up agreements referred to above and subject to compliance with Rule 144 in the case of our affiliates. Sales of a large number of the shares issued under these plans in the public market could have an adverse effect on the market price of the ADSs and the ordinary shares.

***We are a Belgian public limited liability company, and shareholders of our company may have different and, in some cases, more limited shareholder rights than shareholders of a U.S. listed corporation.***

We are a public limited liability company incorporated under the laws of Belgium. Our corporate affairs are governed by Belgian corporate and securities law. The rights provided to our shareholders under Belgian corporate law and our articles of association differ in certain respects from the rights that you would typically enjoy as a shareholder of a U.S. corporation under applicable U.S. federal and state laws. Under Belgian corporate law, other than certain information that we must make public and except in certain limited circumstances, our shareholders may not ask for an inspection of our corporate records, while under Delaware corporate law any shareholder, irrespective of the size of its shareholdings, may do so. Shareholders of a Belgian corporation have more limited rights to initiate a derivative action, a remedy typically available to shareholders of U.S. companies, in order to enforce a right of our Company, in case we fail to enforce such right ourselves.

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A liability action can be instituted for our account by one or more of our shareholders who, individually or together, hold securities representing at least 1.0% of the votes or a part of the capital worth at least €1.25 million and have not approved of the discharge from liability that was granted to the directors. If the court orders the directors to pay damages, they are due to us, though the amounts advanced by the minority shareholders (for example attorney's fees) are to be reimbursed by us. If the action is disallowed, the minority shareholders may be ordered to pay the costs, and should there be grounds therefor, to pay damages to the directors, for example for having conducted provocative and reckless legal proceedings.

In addition, a majority of our shareholders present or represented at our meeting of shareholders may release a director from any claim of liability we may have, provided that the financial position is accurately reflected in the annual accounts. This includes a release from liability for any acts of the directors beyond their statutory powers or in breach of the Belgian Code on Companies and Associations, provided that the relevant acts were specifically mentioned in the convening notice to the meeting of shareholders deliberating on the discharge. In contrast, most U.S. federal and state laws prohibit a company or its shareholders from releasing a director from liability altogether if he or she has acted in bad faith or has breached his or her duty of loyalty to us. Finally, Belgian corporate law does not provide any form of appraisal rights in the case of a business combination. As a result of these differences between Belgian corporate law and our articles of association, on the one hand, and the U.S. federal and state laws, on the other hand, in certain instances, you could receive less protection as an ADS holder of our company than you would as a shareholder of a listed U.S. company.

#### Holders of ADSs may be subject to limitations on the transfer of their ADSs and the withdrawal of the underlying ordinary shares.
ADSs are transferable on the books of the depositary. However, the depositary may close its books at any time or from time to time when it deems expedient in connection with the performance of its duties. The depositary may refuse to deliver, transfer or register transfers of your ADSs generally when our books or the books of the depositary are closed, or at any time if we or the depositary think it is advisable to do so because of any requirement of law, government or governmental body, or under any provision of the deposit agreement, or for any other reason, subject to your right to cancel your ADSs and withdraw the underlying ordinary shares. Temporary delays in the cancellation of your ADSs and withdrawal of the underlying ordinary shares may arise because the depositary has closed its transfer books or we have closed our transfer books, the transfer of ordinary shares is blocked to permit voting at a shareholders' meeting, or we are paying a dividend on our ordinary shares.

In addition, you may not be able to cancel your ADSs and withdraw the underlying ordinary shares when you owe money for fees, taxes and similar charges and when it is necessary to prohibit withdrawals in order to comply with any laws or governmental regulations that apply to ADSs or to the withdrawal of ordinary shares or other deposited securities.

#### As a non-accelerated filer, we are not required to comply with the auditor attestation requirements of the Sarbanes-Oxley Act.
We are a non-accelerated filer under the Exchange Act and we are not required to comply with the auditor attestation requirements of Section 404(b) of the Sarbanes-Oxley Act of 2002. Therefore, our internal controls over financial reporting will not receive the level of review provided by the process relating to the auditor attestation included in annual reports of issuers that are subject to the auditor attestation requirements. In addition, we cannot predict if investors will find our ordinary shares less attractive because we are not required to comply with the auditor attestation requirements. If some investors find our ordinary shares less attractive as a result, there may be a less active trading market for our ordinary shares and the trading price for our ordinary shares may be negatively affected.

***As a foreign private issuer, we are exempt from a number of rules under the U.S. securities laws and are permitted to file less information with the SEC than a U.S. company. This may limit the information available to holders of ADSs or ordinary shares.***

We are a "foreign private issuer," as defined in the SEC's rules and regulations and, consequently, we are not subject to all of the disclosure requirements applicable to public companies organized within the United States. For example, we are exempt from certain rules under the Exchange Act, that regulate disclosure obligations and procedural requirements related to the solicitation of proxies, consents or authorizations applicable to a security registered under the Exchange Act, including the U.S. proxy rules under Section 14 of the Exchange Act. In addition, our officers and directors are exempt from the reporting and "short-swing" profit recovery provisions of Section 16 of the Exchange Act and related rules with respect to their purchases and sales of our securities. Moreover, while we currently make annual and semi-annual filings with respect to our listing on Euronext Brussels and Euronext Paris, we will not be required to file periodic reports and financial statements with the SEC as frequently or as promptly as U.S. domestic issuers and will not be required to file quarterly reports on Form 10-Q or current reports on Form 8-K under the Exchange Act. Accordingly, there will be less publicly available information concerning our company than there would be if we were not a foreign private issuer.

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***As a foreign private issuer, we are permitted to adopt certain home country practices in relation to corporate governance matters that differ significantly from NASDAQ corporate governance listing standards. These practices may afford less protection to shareholders than they would enjoy if we complied fully with corporate governance listing standards.***

As a foreign private issuer listed on NASDAQ, we are subject to corporate governance listing standards. However, rules permit a foreign private issuer like us to follow the corporate governance practices of its home country. Certain corporate governance practices in Belgium, which is our home country, may differ significantly from corporate governance listing standards. For example, neither the corporate laws of Belgium nor our articles of association require a majority of our directors to be independent and we could include non-independent directors as members of our Nomination and Remuneration Committee, and our independent directors would not necessarily hold regularly scheduled meetings at which only independent directors are present. Currently, we intend to follow home country practice to the maximum extent possible. Therefore, our shareholders may be afforded less protection than they otherwise would have under corporate governance listing standards applicable to U.S. domestic issuers. See "Item 16G—Corporate Governance."

***In accordance with Belgian law, we have elected to have double voting rights attach to fully paid-up ordinary shares held of record in the name of the same shareholder for a period of at least two consecutive years, and our significant shareholders and affiliates who are entitled or may become entitled to such double voting rights may be able to exercise an increased direct controlling influence on us.***

In accordance with Belgian law, we have elected to have double voting rights attach to each fully paid-up ordinary share of companies listed on a regulated market (such as the Euronext Brussels and Euronext Paris, where our ordinary shares are listed) that is held of record in the name of the same shareholder for a period of at least two consecutive years. However, under Belgian law, non-registered ordinary shares in the form of ADSs, and dematerialized shares, are not eligible for double voting rights. To our knowledge, among our significant shareholders, double voting rights currently only attach to 2,368,025 ordinary shares as of December 31, 2022, including to the 2,295,701 shares of Tolefi SA.

Furthermore, our current 5% or greater shareholders and affiliated entities, including Fortress Investment Group, may become entitled to double voting rights in the future in which case, our ownership may become concentrated in the hands of our significant shareholders. If they become entitled to double voting rights, these shareholders would have a significant influence over all matters that require approval by our shareholders, such as the election of directors and approval of significant corporate transactions. Such corporate action might be taken even if other shareholders, including those who purchase ordinary shares or ADSs in this offering, oppose them.

This concentration of ownership might also have the effect of delaying or preventing a change of control of our company that other shareholders may view as beneficial. This concentrated control will limit your ability to influence corporate matters for the foreseeable future and potentially in perpetuity. This concentrated control could also discourage a potential investor from acquiring our ADSs or ordinary shares and might harm the market price of our ADSs or ordinary shares. We cannot predict whether the concentrated control of our shareholders who held our ordinary shares prior to the completion of this offering, including our executive officers, employees and directors and their affiliates, will result in a lower or more volatile market price of our ADSs or ordinary shares or in adverse publicity or other adverse consequences.

#### We may lose our foreign private issuer status in the future, which could result in significant additional cost and expense.
While we currently qualify as a foreign private issuer, the determination of foreign private issuer status is made annually on the last business day of an issuer's most recently completed second fiscal quarter and, accordingly, the next determination will be made with respect to us on June 30, 2022. In the future, we would lose our foreign private issuer status if we to fail to meet the requirements necessary to maintain our foreign private issuer status as of the relevant determination date. For example, if more than 50% of our securities are held by U.S. residents and more than 50% of the members of our Executive Committee or members of our Board of Directors are residents or citizens of the United States, we could lose our foreign private issuer status.

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The regulatory and compliance costs to us under U.S. securities laws as a U.S. domestic issuer may be significantly more than costs we incur as a foreign private issuer. If we are not a foreign private issuer, we will be required to file periodic reports and registration statements on U.S. domestic issuer forms with the SEC, which are more detailed and extensive in certain respects than the forms available to a foreign private issuer. We would be required under current SEC rules to prepare our financial statements in accordance with U.S. generally accepted accounting principles, or U.S. GAAP, rather than IFRS, and modify certain of our policies to comply with corporate governance practices associated with U.S. domestic issuers. Such conversion of our financial statements to U.S. GAAP could involve significant time and cost. In addition, we may lose our ability to rely upon exemptions from certain corporate governance requirements on U.S. stock exchanges that are available to foreign private issuers such as the ones described above and exemptions from procedural requirements related to the solicitation of proxies.

#### It may be difficult for investors outside Belgium to serve process on, or enforce foreign judgments against, us or our directors and senior management.
We are a Belgian public limited liability company Less than a majority of the members of our Board of Directors and members of our Executive Committee are residents of the United States. All or a substantial portion of the assets of such non-resident persons and most of our assets are located outside the United States. As a result, it may not be possible for investors to effect service of process upon such persons or on us or to enforce against them or us a judgment obtained in U.S. courts. Original actions or actions for the enforcement of judgments of U.S. courts relating to the civil liability provisions of the federal or state securities laws of the United States are not directly enforceable in Belgium.

The United States and Belgium do not currently have a multilateral or bilateral treaty providing for reciprocal recognition and enforcement of judgments, other than arbitral awards, in civil and commercial matters. In order for a final judgment for the payment of money rendered by U.S. courts based on civil liability to produce any effect on Belgian soil, it is accordingly required that this judgment be recognized or be declared enforceable by a Belgian court in accordance with Articles 22 to 25 of the 2004 Belgian Code of Private International Law. Recognition or enforcement does not imply a review of the merits of the case and is irrespective of any reciprocity requirement. A U.S. judgment will, however, not be recognized or declared enforceable in Belgium if it infringes upon one or more of the grounds for refusal that are exhaustively listed in Article 25 of the Belgian Code of Private International Law. Actions for the enforcement of judgments of U.S. courts might be successful only if the Belgian court confirms the substantive correctness of the judgment of the U.S. court and is satisfied that:

• The effect of the enforcement judgment is not manifestly incompatible with Belgian public policy;

• The judgment did not violate the rights of the defendant;

• The judgment was not rendered in a matter where the parties transferred rights subject to transfer restrictions with the sole purpose of avoiding the application of the law applicable according to Belgian international private law;

• The judgment is not subject to further recourse under U.S. law;

• The judgment is not compatible with a judgment rendered in Belgium or with a subsequent judgment rendered abroad that might be recognized in Belgium;

• A claim was not filed outside Belgium after the same claim was filed in Belgium, while the claim filed in Belgium is still pending;

• The Belgian courts did not have exclusive jurisdiction to rule on the matter;

• The U.S. court did not accept its jurisdiction solely on the basis of either the nationality of the plaintiff or the location of the disputed goods; and

• The judgment submitted to the Belgian court is authentic.

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In addition to recognition or enforcement, a judgment by a federal or state court in the United States against us may also serve as evidence in a similar action in a Belgian court if it meets the conditions required for the authenticity of judgments according to the law of the state where it was rendered. The findings of a federal or state court in the United States will not, however, be taken into account to the extent they appear incompatible with Belgian public policy.

#### We may be subject at an increased risk of securities class action litigation.
Historically, securities class action litigation has often been brought against a company following a decline in the market price of its securities. This risk is especially relevant for us because biotechnology and biopharmaceutical companies have experienced significant share price volatility in recent years. If we were to be sued, it could result in substantial costs and a diversion of management's attention and resources, which could harm our business.

#### Tax law changes could adversely affect our shareholders and our business and financial condition.
We and our subsidiaries are subject to income and other taxes in Belgium, the United States, and other tax jurisdictions throughout the world. Tax laws and rates in these jurisdictions are subject to change. Our financial condition can be impacted by a number of complex factors, including, but not limited to: (i) interpretations of existing tax laws; (ii) the tax impact of existing or future legislation; (iii) changes in accounting standards; and (iv) changes in the mix of earnings in the various tax jurisdictions in which we operate. In recent years, many such changes have been made and changes are likely to continue to occur in the future. Future changes in tax laws could have a material adverse effect on our business, cash flow, financial condition or results of operations. We urge our shareholders to consult with their legal and tax advisors with respect to any such legislation and the potential tax consequences of investing in our ordinary shares or ADSs.

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| **ITEM 4.** | **INFORMATION ON THE COMPANY**  |

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A. History and Development of the Company

Our legal and commercial name is Celyad Oncology SA. On June 10, 2020, we rebranded Celyad SA as Celyad Oncology SA to better reflect our ambition to pioneer CAR T-cell therapies for cancer and more accurately reflect our team's expertise in developing innovative cell therapies against cancer. We are a limited liability company incorporated in the form of a *naamloze vennootschap/société anonyme* under Belgian law. We are registered with the Register of Legal Entities (RPM Nivelles) under the enterprise number 891.118.115. We were incorporated in Belgium on July 24, 2007, for an unlimited duration. Our fiscal year ends December 31.

Our principal executive and registered offices are located at rue Edouard Belin 2 1435 Mont-Saint-Guibert, Belgium and our telephone number is +32 10 394 100. Our agent for service of process in the United States is Celyad Inc., World Financial District, 60 Broad Street, Suite 3502, New York, NY 10004. We also maintain a website at *<u>www.celyad</u>.com*. The reference to our website is an inactive textual reference only and the information contained in, or that can be accessed through, our website is not a part of this Annual Report.

Our actual capital expenditures related to Property, Plant and Equipment, excluding the impact of recognition of right of use assets for the years ended December 31, 2020, 2021 and 2022, amounted to €0.2 million, €0.3 million and €0.1 million, respectively. These capital expenditures primarily consisted of the acquisition of laboratory equipment and the refurbishment of research and development laboratories located in Belgium. The Company expects its capital expenditures to increase in absolute terms in the near term as the Company continues to advance its research and development programs and will relocate its corporate offices in another location in Belgium through the year 2023.

The SEC maintains a website (*www.sec.gov*) that contains reports, proxy and information statements and other information regarding registrants, such as Celyad Oncology SA, that file electronically with the SEC.

B. Business Overview

We are a biotechnology company focused on the discovery and development of innovative technologies for chimeric antigen receptor T-cell (CAR T) therapies. Our goal is to discover and develop proprietary technology platforms to support the development of next-generation CAR T-cell therapy candidates. The Company is focusing on opportunities to fully harness the true potential of its proprietary technology platforms and intellectual property.

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Over the past decades, immunotherapy has become an important treatment option for cancer indications. Within the field of immuno-oncology, chimeric antigen receptor (CAR) T-cell therapy is emerging as a realistic treatment paradigm for patients with advanced disease.

Our differentiated strategy includes the development of technologies and platforms to tackle the current major limitations of CAR T-cell therapies.

#### Allogeneic cell therapy
The majority of CAR T-cell therapies in clinical testing worldwide, including the marketed products, are autologous in nature which means that CAR T-cells are derived from the patients themselves, by collection of the patient's immune cells in the blood through a process called leukapheresis, and are then engineered and reintroduced back into the patient via intravenous infusion. Autologous approaches thereby come with a lag time (weeks to months) between collection of the patient's T-cells and infusion of the CAR T-cell product. Since the patients are of varying age and clinical history, the quality of the initial apheresis product varies and this likely contributes to major variance in the quality of the final product. Moreover, there is a logistical challenge in shipping cells from the medical center to the cell production facilities which means that patients with advanced diseases have a significant possibility of disease progression before they receive the CAR T-cells.

Allogeneic CAR T-cells are prepared in advance from healthy donors and are stored frozen until a patient requires treatment. Hence, allogeneic CAR T-cells are available when required and lack the inherent variability of autologous CAR T-cells. Whilst attractive, the main downside of the allogeneic approach is potential life-threatening toxicity in the form of graft-versus-host disease ("GvHD") that is mediated by the recognition of patient tissues by the T-cell receptor ("TCR") present on the allogeneic CAR T-cells. At the center of allogeneic CAR T-cell therapy, the goal is then to eliminate or blunt the signaling of the TCR through engineering with a specific technology. By reducing the signaling of the TCR, the engineered allogeneic CAR T-cells fail to recognize the patient's healthy tissue as foreign, which avoids GvHD.

Of late, gene-editing technology has enabled the genome-level ablation of components of the TCR thereby enabling banks of allogeneic CAR T-cells lacking GvHD potential to be produced and these are now moving into clinical testing in B-cell malignancies with some preliminary success. However, off-target editing remains a concern to developers and regulators while the practical hurdles to deliver a gene-edited T-cell product are significant including the availability of specific clinical grade reagents and manufacturing strategies in place to enrich the edited T-cells.

Over the past few years, as the CAR T landscape has shifted towards pursuing off-the-shelf approaches, we have continued to steadily progress our allogeneic CAR T-cell franchise and programs by exploring two proprietary, non-gene edited technologies to target the TCR complex: the TIM which has been validated in the clinic with CYAD-101 and the shRNA which has been validated in the clinic with CYAD-211.

#### Targets for broad indications
As of the date of this Annual Report, six autologous CAR T-cells specific for the cluster of differentiation 19 (CD19) or for the B-cell maturation antigen (BCMA) are approved in the United States and in Europe. In addition, one CD19-specific CAR T-cell product is approved in China, and one CD19-specific CAR T-cell product has received authorization in Spain under the "hospital exemption" approval pathway, for a total of eight approved CAR T-cell products as of today. All of them aim to treat a very limited number of B-cell malignancies in which those approaches have shown durable clinical benefit. However, for other malignancies, CAR T-cell therapy has yet to show similar clinical efficacy. The paucity of specific tumor antigens expressed broadly on tumor cells but not on healthy cells, and the strong immunosuppressive and complex microenvironment characterizing the large majority of cancer indications, have limited the success of those approaches to other indications.

In addition, an inherent downside of CAR T-cells targeting a single antigen is that cells not expressing the antigen will not be targeted, which may lead to resistance or relapse after a first response of short duration. Moreover, by applying selective pressure, loss of target antigen expression can occur, also eventually resulting in relapse. Subsequent rescue by administration of CAR T-cells with different antigen-specificity indicates that those tumor cells are still sensitive to CAR T treatment and points towards a multi-target strategy.

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We have developed several CAR T-cell product candidates that were based on NKG2D, a receptor expressed on natural killer (NK) and T-cells, that binds to eight stress-induced ligands broadly expressed on tumor cells across most solid tumors and hematological malignancies. Two autologous product candidates, CYAD-01 and CYAD-02, and an allogeneic counterpart of CYAD-01, CYAD-101, were evaluated in clinical studies between 2016 and 2022. All collected data have shown a tolerable safety profile and has demonstrated some levels of clinical activity in acute myeloid leukemia, myelodysplastic syndrome and colorectal cancer patients.

#### Persistence, activity and infiltration of CAR T-cells
Unlike B-cell malignancies, solid cancers, and some hematological indications, sculpt a tumor microenvironment (TME) that not only restricts lymphocyte trafficking and access to the entire mass of the tumor, but also downregulates the activity, expansion and persistence of the CAR T-cells at the tumor site. The TME represents an intricate cellular and molecular immunosuppressive network formed by aberrant vasculature, stromal cells, immunosuppressive immune cells and extracellular matrix containing inhibitory factors and characterized by oxidative stress, nutritional depletion, acidic pH and hypoxia.

To face those challenges, additional engineering of CAR T-cells and the use of combination therapies hold the potential to endow therapeutic cell products with novel attributes necessary to overcome immunosuppressive aspects of TME.

Central to our pipeline is a cutting-edge all-in-one vector approach where we focus on using a single vector to generate CAR T-cells to simplify the design and development of our cell therapy candidates. The all-in-one vector approach encodes multiple components of the CAR construct simultaneously, including the CAR, shRNA targeting genes involved in alloreactivity, persistence, anti-tumor activity or ability to evade complex or immunosuppressive tumor microenvironments, cell selection marker to assist with the enrichment of the manufactured cells and potential therapeutic add-ons such as cytokines. This single transduction, plug and play approach to CAR T-cell development has the potential to streamline process development and manufacturing while broadening the potential applicability of our candidates.

#### WHAT DIFFERENTIATES CELYAD ONCOLOGY?
The level of activity in the CAR T-cell landscape across the globe has expended rapidly over the last few years. The challenges in immuno-oncology are significant. Most tumors develop undetected over years, fine tuning their capacity to resist treatment, before exploding with clinically relevant disease that rapidly overcomes standard treatment paradigms. Immune-based therapies, including CAR T therapies, are now delivering clinically relevant responses in certain, limited malignancies. The hope is that this initial clinical success with CAR T-cell therapy can be further developed to be effective against a much broader range of cancer.

Scientific progress within the field of cancer immunotherapy has led to seven CAR T-cell therapy approvals, including Kymriah (tisagenlecleucel) developed by Novartis Pharmaceuticals, Yescarta (axicabtagene ciloleucel) developed by Kite Pharma/Gilead, Tecartus (brexucabtagene autoleucel) developed by Kite Pharma/Gilead, Breyanzi (lisocabtagene maraleucel) developed by Juno Therapeutics/Celgene/Bristol Myers Squibb, Abecma (idecabtagene vicleucel) developed by Bluebird/Celgene/Bristol Myers Squibb, Carvykti (Ciltacabtagene autoleucel) developed by Legend Biotech/Janssen Biotech and Carteyva (Relmacabtagene autoleucel) developed by JW Therapeutics. While Carteyva has been approved only in China, all the other six therapies have been approved in the U.S. by the FDA and in Europe by the EMA. In addition, ARI-0001 (CART19-BE-01), developed at Hospital Clínic de Barcelona (Spain), received authorization from the Spanish Agency of Medicines and Medical Devices under the "hospital exemption" approval pathway.

These historic approvals have driven CAR T-cell funding to new heights and CAR T-cell market is expected to potentially generate substantial market value within the next five years.

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*Figure 1: CAR T-cell market increase*![LOGO](g418841g0303225203326.jpg)

As of the date of this Annual Report, our competitors with the adoptive cell therapy landscape, including CAR Ts, TCRs and NK-based cell therapies include but is not limited to 2seventy bio, Inc., Adicet Bio, Inc, Adaptimmune Therapeutics plc, Alaunos Therapeutics Inc., Allogene Therapeutics Inc., AlloVir, Inc, Arcellx, Inc., Atara Biotherapeutics, Inc., Autolus Therapeutics plc, Beam Therapeutics Inc., Bellicum Pharmaceuticals, Inc., Caribou Biosciences, Inc., CARsgen Therapeutics Co. Ltd., Cellectis S.A., Cellular Biomedicine Group, Celularity, Inc., Century Therapeutics, Inc., CRISPR Therapeutics, Inc., Editas Medicines, Inc, Fate Therapeutics, Inc., Gracell Biotechnologies Inc., Immatics Biotechnologies GmbH, ImmunityBio, Inc., Intellia Therapeutics, Inc., Juno Therapeutics, Inc. (acquired by Celgene Corporation, in turn acquired by Bristol Myers Squibb), Kite Pharma, Inc. (acquired by Gilead Sciences, Inc.), Legend Biotech USA, Inc., Lyell Immunopharma, Inc., Medigene AG, Mustang Bio, Inc., Nkarta Therapeutics, Inc., Novartis AG, Poseida Therapeutics, Inc., Precigen, Inc., Precision Biosciences, Inc., Sana Biotechnology, Inc., SQZ Biotech, Inc., TC BioPharm Ltd., TCR2 Therapeutics, Inc., and Tmunity Therapeutics, Inc. (acquired by Kite/Gilead).

The multi billion-dollar CAR T-cell therapy market would not have been possible without the remarkable efficacy of the early CAR T therapies in treating several types of blood cancers. Ranging from small start-ups to very large companies, CAR T-cell companies are proliferating in all healthcare markets worldwide.

As stated above (see Item 4.B), all approved CAR T-cell products are directed against antigens specific for a very limited number of B-cell malignancies in which those approaches have shown durable clinical benefit. However, CAR T-cell therapy has yet to show similar clinical efficacy for other malignancies, including solid cancer indications. Moreover, all approved products are of autologous origin, which comes with a number of limitations including manufacturing and timing constraints, which are not appropriate for broad indications.

Our expertise in oncology, our proprietary technologies, and our differentiated approach to developing innovative technologies for CAR T-cell therapies is providing the tools with which to tackle some of the challenges, including the difficulty of targeting a broad array of hematological and solid tumors. Our solutions include:

**1.** **shRNA platform to design next-generation CAR T-cells** 

In 2021 and 2022, we validated the use of our proprietary shRNA technology as a novel allogeneic platform through our first shRNA-based allogeneic candidate, CYAD-211. CYAD-211 is an allogeneic BCMA-targeting CAR T-cell product candidate employing a single shRNA targeting the CD3z component of the TCR complex to prevent alloreactivity. This validation was established through clinical data generated from the IMMUNICY-1 trial evaluating CYAD-211 (see below in Item 4.B). Additionally, our shRNA technology was also incorporated in the autologous NKG2D-based CAR T-cell candidate, CYAD-02, to improve cell persistence by preventing ligand-mediated fratricide, and was validated in the clinic with data generated from the CYCLE-1 trial (see below in Item 4.B).

The initial clinical validation of the shRNA technology has provided an important milestone event for the Company. The power and versatility of the shRNA platform, including the ability to multiplex and modulate the levels of gene expression, which allows to optimize CAR T-cell features, persistence, efficacy or ability to evade complex or immunosuppressive tumor microenvironments, for both allogeneic or autologous products, continues to support its strength, value, and potential differentiation within the cell therapy landscape (see below in Item 4.B).

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**2.** **Beyond CD19 and BCMA** 

We are currently developing several technologies and future CAR T-cell candidates by exploring underestimated targets including NKG2D ligands and B7-H6 (see below in Item 4.B This would allow to target a broad range of cancers including solid cancer indications and other hematological indications for which no validated target exists as of today.

In addition, we are also exploring multi-targeting approaches, which could be used to decrease risk of relapse or resistance often observed with traditional single-targeting CAR T approaches (see below in Item 4.B).

Through these approaches, we are proposing different solutions, tackling the major current limitations of CAR T-cell therapies as detailed above in Item 4.B.

More recently, a number of studies have built on the success of CAR T-cell therapy in cancer to branch out to other disease areas such as cardiometabolic disorders, autoimmune disease, fibrosis, cellular senescence and infectious pathologies. It is important to mention that the shRNA platform currently developed at Celyad Oncology, as well as the targets explored, could be eventually extended beyond cancer indications. We therefore strongly believe our differentiated strategy could pave the way to a new era of cell therapies.

#### OUR ACTIVITIES AND R&D

#### Allogeneic CAR T-cells:
We are working to advance the field of allogeneic CAR T-cell therapy by exploring two proprietary, non-gene edited technology platforms to target the TCR complex. In adoptive cell therapy, the infusion of donor-derived T-cells to cancer patients with a different background than that of the donor may lead to multiple reactions. These reactions include the donor cells attacking the patient's healthy tissue, known as Graft-versus-Host Disease, or GvHD, as well as the rejection of the therapy by the patient's immune system known as Host-versus-Graft, or HvG, reaction.

Since the TCR, a molecule present on the surface of T cells, is principally responsible for GvHD, the goal of "off-the-shelf" allogeneic cell therapies is to eliminate or blunt the signaling of the TCR through engineering with a specific technology.

Our non-gene edited technologies target the TCR specifically without extensive genetic manipulation. Through the co-expression of our non-gene edited technologies with a specific CAR of interest, we can design cell therapy candidates intended to inhibit the function of the TCR while allowing the T-cells to target the cancer. We believe this unique strategy offers a streamlined approach in advancing the allogeneic CAR T-cell landscape.

#### Dual CAR T platform:
The targeting of a single antigen by CAR T-cells, has been shown to be problematic in certain malignancies, whereas efficacy of CAR T-cell therapy has not been observed in other cases. The reasons behind the possible failure of single targeting CAR T-cells are multi-factorial and include the tumor microenvironment, antigen escape or loss among others. With a multi- or dual-targeting CAR, several antigens can be targeted together by the same CAR product so that if there is a loss of one antigen, there are still others that can work to kill the cancer cells.

We therefore developed a dual CAR platform focusing on the NKG2D receptor. The NKG2D receptor specifically targets NKG2D ligands (NKG2DL) that are induced by different stress responses. This offers a very different strategy from dual CAR T-cells that target similar antigens such as CD19/CD20. By targeting NKG2DL a broader range of antigens can be targeted simultaneously, that are not limited to only one specific tumor indication. The antigens are associated with both the tumor microenvironment as well as the tumor tissue itself. Thus the application of NKG2D based dual CAR T-cells is suitable not only in situations where antigen escape and/or loss may occur, but in situations where multiple organs are impacted, such as is the case of metastatic and advanced solid cancers. These malignancies are very difficult to target with conventional means, and use of a NKG2D-based dual CAR platform may offer a much needed alternative.

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As part of our efforts to identify new targets expressed by a broad range of indications, we are currently developing B7-H6-targeting immunotherapies. In cancers, B7-H6 expression is associated with tumor progression, poor prognosis and lymph node metastasis. B7-H6 may be used to recognize and kill tumor cells, and we believe it is an underappreciated target that could change the paradigm of cell therapy due to its broad expression in a large variety of cancers and absence from healthy cells.

#### Our Proprietary Short Hairpin RNA (shRNA) Technology:
shRNA is a small piece of RNA that can decrease gene expression, effectively turning genes off. shRNA is a dynamic, innovative technology that allows, among others, for the development of allogeneic CAR T-cells through the modulation of gene expression of the TCR without the need for gene-editing. Beyond its use to generate allogeneic cell therapies, shRNA can be used to modulate other genes, including essential functional genes and genes whose partial expression is required, to provide broad therapeutic functionalities. We are currently engineering T-cells for specific desired features, including increased persistence, enhanced antitumor activity, ability to evade complex or immunosuppressive tumor microenvironments or potentially improved tolerability. We believe that shRNA offers us the ability to design and develop next-generation, non-gene edited allogeneic CAR T therapies with any CAR across a broad array of targets.

Furthermore, we have successfully multiplexed the shRNA technology to enable the targeting of multiple targets in parallel using our all-in-one vector system. This is of great importance as in most cases a single target will offer only limited uses. For example, in the case of allogeneic candidates, one target is needed to combat GvHD and additional targets are needed to combat recognition by the host immune system, in order to improve cell persistence. Similarly, immune checkpoint inhibitors are important targets for downregulation since multiple tumors have been shown to express the ligands to these receptors. As immune checkpoint inhibitors can suppress T-cell cytotoxicity, they could be involved in the inhibition of CAR T-cell responses, or other T-cell mediated responses. Immune checkpoint inhibitors encompass a group of multiple receptors that include PD-1, LAG-3 and many others. The large number of candidates for down regulation at once makes these perfect candidate targets for our shRNA technology.

Next to the ability to downregulate the target (or targets) of interest, the dynamic range that can be achieved using the shRNA multiplexed platform means that the expression of each candidate protein can be modulated. This is of importance in instances when a reduction in the protein expression is of benefit rather than complete removal of the protein expression. There are multiple proteins within T-cells that play crucial roles in the skewing of T-cell functionality, efficacy, persistence and survival, that need to be down-tuned rather than simply removed. This is, for example, the case when HLA class I is completely removed. Removal of this protein leads to recognition of the cell by host NK cells, which in turn will lead to low cell persistence. Modulating the protein expression to such an extent that it is not targeted by NK cells can help the engineered cells evade the host immune system.

Currently the shRNA multiplexing platform has been validated to include up to 4 different targets in a plug and play manner.

#### shRNA Armored CAR T (shARC) Platform:
In addition, we are developing an armored CAR franchise in conjunction with our shRNA technology, referred to as shRNA Armored CAR T platform, or shARC. The shARC platform uses our shRNA technology in combination with a CAR and a specific cytokine to enhance the anti-tumor effects of the cell therapy and optimize the potential treatment for cancer patients. Initial efforts using the shARC platform have been centered on the use of shRNA technology to knockdown CD3z for the generation of allogeneic CAR T-cells in combination with the co-expression of the pro-inflammatory cytokine IL-18.

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#### CLINICAL PROGRAMS
Entering 2022, Celyad Oncology was investigating a diversified pipeline of next-generation allogeneic and autologous CAR T candidates:

*CYAD-101*

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| ![LOGO](g418841g0303225203853.jpg) | CYAD-101 is an investigational, non-gene edited allogeneic CAR T candidate engineered to co-express the chimeric antigen receptor based on NKG2D, the novel inhibitory peptide TIM and a truncated CD19 selection marker. The product candidate leverages our All-In-One vector approach with a single transduction, avoiding multiple genetic modifications and costs associated with additional GMP grade materials. TIM inhibits CD3z and reduces signaling of the TCR complex, which reduces the potential for GvHD. |

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<u>alloSHRINK Phase 1 Trial Overview</u> 

In December 2018, we initiated the Phase 1 alloSHRINK trial, an open-label trial assessing the safety and clinical activity of three consecutive administrations of CYAD-101 every two weeks administered following preconditioning chemotherapy in patients with refractory unresectable mCRC. The dose-escalation segment of the trial evaluated the administrations of CYAD-101 concurrently with FOLFOX (combination of 5-fluorouracil, leucovorin and oxaliplatin) chemotherapy regimen at three dose levels (1×108, 3×108, 1×109 cells per infusion). In December 2020, we began enrollment in the expansion cohort of the alloSHRINK trial, which evaluated three infusions of CYAD-101 at the recommended dose of 1×109 cells per infusion of CYAD-101 concurrently with FOLFIRI (combination of 5-fluorouracil, leucovorin and irinotecan) preconditioning chemotherapy for the treatment of advanced mCRC.

<u>Phase 1 alloSHRINK Clinical Trial Data</u> 

Initial positive data from the alloSHRINK trial were reported both at the Society for Immunotherapy of Cancer (SITC) 2019 and American Society of Clinical Oncology 2020 conferences. In January 2021, we reported additional translational data for the alloSHRINK trial at the American Society of Clinical Oncology 2021 Gastrointestinal Cancers Symposium.

A total of 15 patients with relapsed/refractory mCRC who progressed after previous treatment with oxaliplatin-based or irinotecan-based chemotherapies were enrolled in the alloSHRINK Phase 1 dose-escalation trial. The number of prior therapies received by patients enrolled in the trial ranged from one to six with a mean of three.

Data from the trial showed that CYAD-101 following preconditioning chemotherapy was observed to be generally well-tolerated with no GvHD observed, no dose-limiting toxicities reported, no patient discontinuation due to treatment-related adverse events and no treatment-related adverse events greater than Grade 3. Results also showed two patients achieved a partial response (PR) according to RECIST 1.1 criteria, including one patient with a KRAS-mutation.

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Nine patients achieved stable disease (SD), with seven patients demonstrating disease stabilization lasting more than or equal to three months of duration, with a disease control rate of 73%.

![LOGO](g418841g0303225204090.jpg)

Median progression free survival (mPFS) for this segment of the trial was 3.9 months, and median overall survival (mOS) was 10.6 months. No correlation was observed between clinical responses and the degree of human leukocyte antigen (HLA) matching between patients and CYAD-101 donor cells, indicating that CYAD-101 may be able to be used in a broad patient population regardless of the HLA haplotype.&nbsp;&nbsp;&nbsp;&nbsp;

Data from the alloSHRINK trial also showed a tumor burden decrease in eight out of 15 evaluable patients, including six of nine patients at dose level 3. Clinical activity was observed across all dose levels. There was no obvious correlation between response, dose-levels nor baseline characteristics.

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| ![LOGO](g418841g0303225204291.jpg) | Of four patients treated at the highest dose level of 1×10<sup>9</sup> CYAD-101 cells per infusion available for analysis, three patients who achieved either a confirmed PR or SD also showed hyper-expanded TCR repertoire post-treatment through the emergence of new T cell clones in the peripheral blood T cell repertoire, while one patient with progressive disease displayed no evidence of new T cell clones. |

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Cytokine modulation was also observed after the first and second infusions of CYAD-101 in the patient who achieved a confirmed PR from the highest dose level.

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All 15 patients from the dose-escalation segment of the alloSHRINK trial were dosed from a single cell bank of CYAD-101 that was generated in advance from two manufacturing runs each using a fraction of an apheresis from a single healthy donor.

Preliminary data from the dose expansion cohort evaluating CYAD-101 (1×109 cells per infusion) following FOLFIRI (combination of 5-fluorouracil, leucovorin and irinotecan) preconditioning chemotherapy showed CYAD-101 was generally well-tolerated with no dose limiting toxicities or evidence of GvHD. Overall, nine out of ten evaluable mCRC patients showed stable disease at first tumor assessment. Data also showed shorter persistence of CYAD-101 cells observed after FOLFIRI preconditioning as compared to FOLFOX preconditioning.

In 2021, based on better cell kinetic data and clinical activity data from the alloSHRINK dose-escalation segment of CYAD-101 following FOLFOX preconditioning, the Company submitted a protocol amendment to regulatory agencies to modify the Phase 1b KEYNOTE-B79 trial to incorporate FOLFOX as preconditioning chemotherapy.

Following the decision to use FOLFOX in the KEYNOTE-B79 study, enrollment into the alloSHRINK study was discontinued in April 2021. Patients have continued to be followed up as required by protocol. As of December 31, 2022, four patients remained in follow-up.

<u>Phase 1b CYAD-101-002 (KEYNOTE-B79) Trial Overview</u> 

In September 2020, we announced a clinical trial collaboration with MSD, a tradename of Merck. The CYAD-101-002 trial was designed to evaluate CYAD-101 following FOLFOX preconditioning chemotherapy, with Merck's anti-PD1 therapy, KEYTRUDA<sup>®</sup> (pembrolizumab), in refractory mCRC patients with MSS / pMMR disease. In December 2021, we announced the first patient was dosed in the trial. In February 2022, we announced our decision to voluntarily pause the CYAD-101-002 trial to investigate reports of two fatalities that presented with similar pulmonary findings and evaluate any similar events in additional patients treated on study. On March 1, 2022, we were informed via-email communication from the FDA that the CYAD-101-002 trial had been placed on clinical hold due to insufficient information to assess risk to study subjects.

In June 2022, we submitted our complete response to the Clinical Hold to the FDA stating our intent to amend the eligibility criteria to exclude patients who have bilateral lung metastases and patients who have received treatment with epidermal growth factor receptor (EGFR) targeting monoclonal antibodies within the previous 9 months prior to trial recruitment. In July 2022, based on that complete response, we received notification that the FDA lifted the Clinical Hold on the trial.

In October 2022, we announced that, based on a strategic, financial and medical review, taking into account the costs associated with the pursuit of the program and the delays to reach key medical milestones following the resolution of the previous Clinical Hold, the Company had decided to discontinue the development of CYAD-101. There were no new safety concerns leading to this decision. As the decision to pause the study was taken before any patients had completed their first full cycle of treatment, we do not have follow-up disease assessment data to make any evaluation of the efficacy of the FOLFOX, CYAD-101 and pembrolizumab treatment.

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*CYAD-211*

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| ![LOGO](g418841g0303225204498.jpg) | CYAD-211 is an investigational shRNA-based allogeneic CAR T candidate for the treatment of relapsed or refractory multiple myeloma (r/r MM). CYAD-211 is engineered to co-express a BCMA chimeric antigen receptor and a single shRNA hairpin which interferes with the expression of the CD3z component of the TCR complex |

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<u>Phase 1 IMMUNICY-1 Trial Overview</u> 

In November 2020, we initiated the dose-escalation Phase 1 IMMUNICY-1 trial evaluating CYAD-211.

IMMUNICY-1 is an open-label Phase 1, dose-escalation trial that has evaluated the safety and clinical activity of a single infusion of CYAD-211 following preconditioning with CyFlu chemotherapy -cyclophosphamide and fludarabine in patients with r/r MM. The trial was initially designed to evaluate multiple dose levels of CYAD-211: 3x107, 1x108 and 3x108 cells per infusion following preconditioning chemotherapy cyclophosphamide (300 mg/m² for 3 days) and fludarabine (30 mg/m² for 3 days). Following protocol amendments, additional patients were treated with enhanced lymphodepletion (eLD) with higher doses of cyclophosphamide (500 and 750mg/m² for 3 days) and fludarabine (30mg/m² for 4 days) and three patients were treated with 6x108 cells per infusion after preconditioning with the higher eLD dose.

Preliminary data from the IMMUNICY-1 trial showed a favorable tolerability profile with no DLTs, no GvHD and no CAR T-cell-related encephalopathy syndrome.

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| ![LOGO](g418841g0303225204688.jpg) | Preliminary cell kinetic data in the first three cohorts of the dose escalation showed all patients had detectable CYAD-211 cells in the peripheral blood, although engraftment was short lasting. This suggested expansion and persistence of cells might be more dependent on the depth and period of the lymphodepletion induced by the preconditioning regimen, which called for further exploration of lymphodepletion. However, following protocol amendment, data with enhanced lymphodepletion with higher doses of preconditioning chemotherapy (cohorts 4 to 6), cell kinetic data continued to show short persistence of engraftment.<br>Initial clinical activity from 12 patients in the initial dose-escalation segment of the IMMUNICY-1 trial was encouraging with three patients achieving partial response (PR), one in each dose-level, while eight patients had stable disease (SD). One patient with SD of 4.5 months duration showed evidence of reduction in size of plasmacytomas on radiographic studies. |

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Seven additional patients received eLD including three who also received the higher dose of cells. Two of these eLD patients have achieved PR.

![LOGO](g418841g0303225204871.jpg)

As of December 2022, 19 r/r MM patients had been treated with CYAD-211 in the IMMUNICY-1 trial. The observed safety profile, including the lack of observed Graft-versus-Host disease, provides proof-of-concept for the use of shRNA technology for allogeneic CAR T-cells.

In total, out of 17 evaluable patients across all dosing cohorts, a partial response was achieved in five patients. One patient was re-treated with a second dose of CYAD-211 after having reached stable disease post first infusion. The patient tolerated the second dose. Enhanced lymphodepletion did not seem to improve clinical activity nor persistence of the CAR T-cells post-infusion.

On December 21, 2022, the Company announced that, based on a strategic and financial review, the Company had decided to discontinue the development of CYAD-211. There were no safety concerns leading to this decision and all patients previously treated with CYAD-211 will continue to receive their protocol-defined follow-up. As of December 31, 2022, 11 patients remained in follow-up.

*CYAD-02*

CYAD-02 is an investigational CAR T therapy that uses an All-in-One vector approach to engineer a patient's T cells to express both the NKG2D chimeric antigen receptor and shRNA technology to knockdown the expression of NKG2D ligands MICA and MICB on the CAR T-cells.

In preclinical models, targeting MICA and MICB with a single shRNA leads to a decrease of ligand expression (Figure A) on T cells and enhanced *in vitro* expansion (Figure B) compared to a first-generation autologous NKG2D CAR T product candidate.

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![LOGO](g418841g0303225205044.jpg)

<u>CYCLE-1 Trial</u> 

In November 2019, we initiated the Phase 1 dose-escalation CYCLE-1 trial that evaluated the safety and clinical activity of a single infusion of CYAD-02 following preconditioning chemotherapy with cyclophosphamide and fludarabine for the treatment of relapsed or refractory (r/r) acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).

In December 2021, we reported data from the Phase 1 CYCLE-1 trial at the American Society of Hematology annual meeting, which overall showed a good tolerability profile of CYAD-02 following CyFlu preconditioning.

Data from the trial showed that a single shRNA can target two independent genes (MICA/MICB) to enhance the phenotype of the CAR T-cells. In addition, the dual knockdown showed a positive contribution to the initial clinical activity of CYAD-02 as well as a trend towards increased engraftment and persistence compared to the first-generation, autologous NKG2D receptor CAR T.

In August 2022, we announced that we would seek partnerships to continue the development of CYAD-02. As of December 31, 2022, no partnerships had been announced. No patients are in follow-up.

<u>Long Term Safety Follow-Up</u> 

According to the guidelines for gene therapy for vectors which may undergo latency/reactivation, patients who have been treated in clinical trials of gene therapy should continue to be followed after discontinuation of study treatment for 5 years following exposure to the product candidate in the parent study, followed by 10 years of annual visits for patients with a post-treatment test positive for replication-competent retrovirus (RCR) during Year 1 (i.e., the first year after the first product candidate treatment in the parent study).

To ensure compliance with this requirement, all previous Celyad-sponsored studies included such long-term follow-up in the respective protocol. However, since they are no longer recruiting, no more study treatments are planned, and the treatment follow-up period will end soon or has been completed, Celyad has decided to amend the protocols of the parent studies so that long-term safety follow-up (LTSFU) of patients will be done under this common LTSFU protocol instead of under the respective parent protocols. Surviving patients from all previous Celyad-sponsored clinical trials who have received CAR T product candidates will be followed in this new LTSFU study.

The LTSFU study aims to identify and mitigate the long-term risks in terms of serious adverse events (SAEs) related to the product candidates or study participation, and fatal SAEs. Additionally, it will allow Celyad to further understand the persistence of its product candidates. The LTSFU study includes annual visits/telephone contacts for all patients.

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#### OUR MANUFACTURING CAPABILITIES
We have focused our efforts on an allogeneic approach for the past few years and our manufacturing facility and staff have been a key element to enable many of our past trials but have been underutilized in recent years as we mainly used the facility for our autologous candidates. Our current allogeneic programs are better suited for outsourced manufacturing.

In September 2022, the Company entered into a €6.0 million asset purchase agreement with Cellistic, the cell therapy development and manufacturing business of Ncardia Belgium BV, whereby Cellistic acquired Celyad Oncology's Good Manufacturing Practice (GMP) grade Cell Therapy Manufacturing Unit composed notably of personnel, equipment, supplier and service contracts and stock.

#### LICENSING AND COLLABORATION AGREEMENTS

#### Celdara

#### Background
In January 2015, we entered into an agreement with Celdara Medical, LLC, or Celdara in which we purchased all outstanding membership interests of OnCyte, LLC, or OnCyte. In connection with this transaction, we entered into an asset purchase agreement to which Celdara sold to OnCyte certain data, protocols, regulatory documents and intellectual property, including the rights and obligations under two license agreements between OnCyte and The Trustees of Dartmouth College, or Dartmouth, related to our CAR T development programs.

In March 2018, we dissolved the affairs of our wholly owned subsidiary OnCyte. As a result of the dissolution of OnCyte, all the assets and liabilities of OnCyte were fully distributed to us including under our license agreement with Dartmouth.

#### Amended Asset Purchase Agreement
In August 2017, we entered into an amendment to the asset purchase agreement described above. In connection with the amendment, the following payments were made to Celdara: (i) an amount in cash equal to $10.5 million, (ii) newly issued shares of Celyad valued at $12.5 million, (iii) an amount in cash equal to $6.0 million in full satisfaction of any payments owed to Celdara in connection with a clinical milestone related to our CAR T NKR-2 product candidate, (iv) an amount in cash equal to $0.6 million in full satisfaction of any payments owed to Celdara in connection with our license agreement with Novartis International Pharmaceutical Ltd., and (v) an amount in cash equal to $0.9 million in full satisfaction of any payments owed to Celdara in connection with our former license agreement with Ono Pharmaceutical Co., Ltd.

Under the amended asset purchase agreement, we are obligated to make certain development-based milestone payments to Celdara up to $40.0 million, certain development-based milestone payments up to $36.5 million and certain sales-based milestone payments up to $156.0 million. We are required to make tiered single-digit royalty payments to Celdara in connection with the sales of CAR T products, subject to reduction in countries in which there is no patent coverage for the applicable product or in the event Celyad is required to secure licenses from third parties to commercialize the applicable product. We are also required to pay Celdara a percentage of sublicense income, including royalty payments, for each sublicense ranging from the mid-single digits to the mid-twenties, depending on which of a specified list of clinical and regulatory milestones the applicable product has achieved at the time the sublicense is executed. We are required to pay Celdara a single-digit percentage of any research and development funding received by us, not to exceed $7.5 million for each product group. We can opt out of the development of any product if the data does not meet the scientific criteria of success. We may also opt out of development of any product for any other reason upon payment of a termination fee of $2.0 million to Celdara.

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#### The Trustees of Dartmouth College ("Dartmouth")
As described above, as a result of our acquisition of all of the outstanding membership interests of OnCyte and the asset purchase agreement among us, Celdara and OnCyte, OnCyte became our wholly-owned subsidiary and acquired certain data, protocols, regulatory documents and intellectual property, including the rights and obligations under two license agreements between OnCyte and Dartmouth. The first of these two license agreements concerned patent rights related, in part, to methods for treating cancer involving chimeric NK and NKP30 receptor targeted therapeutics and T cell receptor-deficient T cell compositions in treating tumor, infection, GVHD, transplant and radiation sickness, or the CAR T License, and the second of these two license agreements concerned patent rights related, in part, to anti-B7-H6 antibody, fusion proteins and methods of using the same, or the B7H6 License.

In August 2017, we and Dartmouth entered into an amendment agreement in order to combine our rights under B7H6 Agreement with our rights under the CAR T License, resulting in the termination of the B7H6 License, and in order to make certain other changes to the agreement. In connection with the amendment, we paid Dartmouth a non-refundable, non-creditable amendment fee in the amount of $2.0 million in 2017. Under the amended license agreement, Dartmouth granted us an exclusive, worldwide, royalty-bearing license to certain know-how and patent rights to make, have made, use, offer for sale, sell, import and commercialize any product or process for human therapeutics, the manufacture, use or sale of which, is covered by such patent rights or any platform product. Dartmouth reserves the right to use the licensed patent rights and licensed know-how, in the same field, for education and research purposes only. The patent rights included in the amended license agreement also include the patents previously covered by the B7H6 License. In consideration for the rights granted to us under the amended license agreement, we are required to pay to Dartmouth an annual license fee as well as a low single-digit royalty based on annual net sales of the licensed products by us, with certain minimum net sales obligations beginning April 30, 2024, and continuing for each year of sales thereafter. Under the amended license agreement, in lieu of royalties previously payable on sales by sublicensees, Celyad is required to pay Dartmouth a percentage of sublicense income, including royalty payments, (i) for each product sublicense ranging from the mid-single digits to low-single digits, depending on which of a specified list of clinical and regulatory milestones the applicable product has achieved at the time the sublicense is executed and (ii) for each platform sublicense in the mid-single digits. Additionally, the agreement requires that we exploit the licensed products, and we have agreed to meet certain developmental and regulatory milestones. Upon successful completion of such milestones, Celyad is obligated to pay to Dartmouth certain clinical and regulatory milestone payments up to an aggregate amount of $1.5 million and a commercial milestone payment in the amount of $4.0 million. We are responsible for all expenses in connection with the preparation, filing, prosecution and maintenance of the patents covered under the agreement.

As further amended in December 2021, this agreement allows Dartmouth to terminate the amended license after April 30, 2026, extended from the prior date of April 30, 2024, in the event that Celyad fails to meet the specified minimum net sales obligations for any year (USD 10 million during first year of sales, USD 40 million during the second year of sales and USD 100 million during the third year of sales and every year of sales thereafter), unless Celyad pays to Dartmouth the royalty Celyad would otherwise be obligated to pay had Celyad met such minimum net sales obligation. Dartmouth may also terminate the license if Celyad fails to meet a milestone within the specified time period, unless Celyad pays the corresponding milestone payment. In connection with the December 2021 amendment, we agreed to certain protective provisions of any sublicenses and paid Dartmouth a non-refundable, non-creditable amendment fee and an additional non-refundable, non-creditable sublicense fee to be paid on an annual basis.

#### Novartis
On May 1st, 2017, we entered into a non-exclusive license agreement with Novartis International AG, or Novartis, regarding U.S. patents related to allogeneic CAR T-cells. The agreement includes our intellectual property rights under U.S. Patent No. 9,181,527. This agreement is related to two undisclosed targets currently under development by Novartis. Under the terms of the agreement, we received an upfront payment of $4.0 million and are eligible to receive additional milestone payments in aggregate amounts of up to $92.0 million. In addition, we are eligible to receive royalties based on net sales of the licensed target associated products at percentages in the single digits. We retain all rights to grant further licenses to third parties for the use of allogeneic CAR T-cells.

#### Horizon Discovery Group/PerkinElmer
In April and June 2018, we signed two research and development collaboration and license agreements with Horizon Discovery Group plc, or Horizon, to evaluate the utility of Horizon's SMART vector shRNA reagents to reduce expression of one or more defined targets in connection with the development of our product candidates. The first agreement was focused on targets related to our autologous CAR T candidate, CYAD-02. The second agreement was focused on targets related to our allogenic CAR T product candidate CYAD-211 and one pre-clinical allogenic product candidate not yet publicly announced, called CYAD-203.

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In December 2018, we exercised our option to convert the second agreement into an exclusive license agreement, in connection with which we paid Horizon an up-front payment of $1 million. In September 2019, we exercised our option to convert the first agreement into an exclusive license agreement, in connection with which we have paid Horizon an up-front payment of $0.1 million and an additional milestone of $0.1 million for the first IND filed by us for CYAD-02. In September 2020, we paid an additional milestone of $0.2 million for the first IND filed by us for CYAD-211.

Under these exclusive license agreements combined, Horizon is eligible to receive additional milestone payments in development, regulatory and commercial milestone payments, in addition to low single digit royalties on net sales, subject to customary reductions.

In December 2020, Horizon Discovery was acquired by PerkinElmer, Inc. (Horizon/PKI).

In 2021, Horizon/PKI informed us they believe we are in material breach of these agreements as a result of certain disclosures we have made in connection with our obligations as a publicly traded company in the United States and Belgium, although they have not formally delivered to us a notice of material breach or termination. We believe any such assertion of material breach would be without merit and we would expect to vigorously defend any such notice of material breach. Any dispute under these agreements would be subject to arbitration in The Hague under the International Chamber of Commerce Rules. We are currently in discussions with Horizon about possible amendments to these agreements in connection with which we would retain freedom to operate under the in-licensed patents.

Of note, we have filed patent applications which, if issued, would cover other aspects of the product candidates described above as well as products developed by third parties that deploy similar technology and targets. These patent applications encompass the downregulation of one or more of the targets covered under the Horizon/PKI agreements, the use of shRNA to downregulate such targets in immune cells and the combination of shRNAs with a chimeric antigen receptor in immune cells. We are also developing a second generation shRNA platform that does not incorporate any of the Horizon Discovery/Perkin Elmer, Inc. technology described above.

Our discontinued allogeneic CAR T product candidate, CYAD-101, does not incorporate any of the Horizon Discovery/Perkin Elmer, Inc. technology described above.

#### Merck
In September 2020, we entered into a clinical trial collaboration agreement and subsequent agreements with MSD International GmbH, or MSD, a subsidiary of Merck & Co., Inc. The agreements relate to the Phase 1b KEYNOTE-B79 clinical trial, which will evaluate our investigational non-gene edited allogeneic CAR T candidate, CYAD-101, following FOLFOX preconditioning chemotherapy, with MSD's anti-PD-1 therapy, KEYTRUDA<sup>®</sup> (pembrolizumab). The trial will enroll refractory metastatic colorectal cancer (mCRC) patients with microsatellite stable (MSS) / mismatch-repair proficient (pMMR) disease, with the initial goal of determining the safety and tolerability of the combination therapy. The trial began enrollment in the fourth quarter of 2021.

In February 2022, we announced our decision to voluntarily pause the KEYNOTE-B79 trial to investigate reports of two fatalities that presented with similar pulmonary findings and evaluate any similar events in additional patients treated on study. On March 1, 2022, the Company was informed via-email communication from the FDA that the KEYNOTE-B79 trial has been placed on clinical hold due to insufficient information to assess risk to study subjects. In October 2022, the Company decided to discontinue the development of CYAD-101 based on a strategic, financial and medical review. As per the mutual agreement between both companies in December 2022, the clinical trial collaboration agreement has been terminated without any further liabilities.

#### Mesoblast
On May 8, 2018, we entered into a license agreement with Mesoblast, an Australian biotechnology company, to develop and commercialize our intellectual property rights relating to C-Cathez, an intra-myocardial injection catheter, related to our former cardiovascular business, for which Mesoblast has paid to Celyad an upfront fee of 1,000,000 USD. In addition to the upfront fee, Celyad may be eligible up to 20,000,000 USD in clinical, regulatory and commercial milestone payments payable in cash or, for certain milestones, in Mesoblast shares.&nbsp;&nbsp;&nbsp;&nbsp;

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On January 17, 2022, we entered into an amendment with Mesoblast to convert the license into non-exclusive, to remove the termination fee of 2,500,000 USD from Mesoblast and to extend certain payments milestones. In consideration for this amendment, Mesoblast has agreed to pay to Celyad 1,500,000 USD in Mesoblast ordinary shares.

#### Intellectual Property

#### Patents and Patent Applications
Patents, patent applications and other intellectual property rights are important in the sector in which we operate. We consider on a case-by-case basis filing patent applications with a view to protecting certain innovative products, processes, and methods of treatment. We may also license or acquire rights to patents, patent applications or other intellectual property rights owned by third parties, academic partners or commercial companies which are of interest to us.

Our patent portfolio includes pending patent applications and issued patents in the United States and in foreign countries.

The term of a U.S. patent may be eligible for patent term extension under the Hatch-Waxman Act to account for at least some of the time the drug or device is under development and regulatory review after the patent is granted. With regard to a drug or device for which FDA approval is the first permitted marketing of the active ingredient, the Hatch-Waxman Act allows for extension of the term of one U.S. patent. The extended patent term cannot exceed the shorter of five years beyond the non-extended expiration of the patent or 14 years from the date of the FDA approval of the drug or device. Some foreign jurisdictions have analogous patent term extension provisions that allow for extension of the term of a patent that covers a device approved by the applicable foreign regulatory agency.

*NKR-T Cell Platform Patents* 

As of February 17, 2023, our CAR T-cell portfolio includes four patent families exclusively licensed to us by Dartmouth. This portfolio includes twenty-one issued U.S. patents; nine pending U.S. patent applications; and 26 foreign granted patents and applications pending in jurisdictions including Australia, Brazil, Canada, China, Europe, Hong Kong, India, Japan, Mexico and Russia. These patents and patent applications relate to specific chimeric antigen receptors and to T-cell receptor deficient T-cells and are further detailed below.

A first patent family relates to chimeric NK receptors and methods for treating cancer. There are five granted U.S. patents in this family (US 7,994,298; US 8,252,914; US 10,336,804; US11,208,454; and US11,339,199) and two further pending US applications. The scope of this patent family includes chimeric natural killer cell receptors (NKR CARs), T-cells with such receptors (NKR CAR T-cells) and methods of treating cancer with these NKR CAR T-cells.

A second patent family is entitled "NKp30 receptor targeted therapeutics" and describes a specific NKR CAR based on the NKp30 receptor. Two U.S. patents are granted (US 9,833,476 and US 10,682,378) and there is a further U.S. application pending.

A third family relates to an anti-B7H6 antibody, CARs and BiTE molecules containing the antibody; to CAR T-cells; and methods of treating cancer with the CAR T-cells. Two U.S. patents are granted (US9,790,278 and US11,034,766), patents have also been granted in Europe, China and Japan, and applications are pending in China, Europe and the United States.

A fourth patent family relates to T-cell receptor-deficient compositions. TCR deficient human T-cells could be particularly useful to generate allogeneic CAR T-cells. The family includes members that relate to the concept (irrespective of the way the T-cell is made TCR deficient), as well as members describing specific ways of making the cells TCR deficient. There are twelve granted U.S. patents in this family (US 9,181,527; US 9,273,283; US9,663,763; US9,822,340; US9,821,011; US 9,938,497; US 9,957,480; US 10,689,616; US 10,689,617; US 10,689,618; US 10,689,619, and US 11,136,549), as well as five further pending US applications and ten applications in other jurisdictions.

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*shRNA Platform Patents* 

In addition to the in-licensed patents mentioned above, we file patent applications for our in-house developed technologies. Exemplary applications are those related to our proprietary shRNA platform. There are currently three patent families pending in this portfolio. No patents have been granted yet, but applications are pending in Australia, Canada, China, Europe, Japan, South-Korea and the US.

*Trade Secrets* 

In addition to our patents and patent applications, we keep certain of our proprietary information as trade secrets, which we seek to protect by confidentiality agreements with our employees and third parties, and by fragmenting know-how between different individuals, in accordance with standard industry practices.

#### Competition
The industry in which we operate is subject to rapid technological change. We face competition from pharmaceutical, biopharmaceutical and biotechnology companies, as well as from academic and research institutions. Some of these competitors are pursuing the development of medicinal products and other therapies that target the same diseases and conditions that we are targeting.

Some of our current or potential competitors, either alone or with their collaboration partners, have significantly greater financial resources and expertise in research and development, manufacturing, preclinical testing, conducting clinical trials and marketing approved products than we do. Mergers and acquisitions in the pharmaceutical, biotechnology and gene therapy industries may result in even more resources being concentrated among a smaller number of our competitors. Smaller or early-stage companies may also prove to be significant competitors, particularly through collaborative arrangements with large and established companies. These competitors also compete with us in recruiting and retaining qualified scientific and management personnel and establishing clinical trial sites and patient registration for clinical trials, as well as in acquiring technologies complementary to, or necessary for, our programs.

Our commercial opportunity could be reduced or eliminated if our competitors develop and commercialize products that are safer, more effective, have fewer or less severe side effects, are more convenient or are less expensive than any products that we may develop. Our competitors also may obtain FDA or other regulatory approval for their products more rapidly than we may obtain approval for ours, which could result in our competitors establishing a strong market position before we are able to enter the market. The key competitive factors affecting the success of all of our programs are likely to be their efficacy, safety and convenience.

Many of our competitors have substantially greater financial, technical and other resources.

For a breakdown of our total revenues by activity and geographic market, please see "Note 6—Operating segment information" in our consolidated financial statements appended to this Annual Report.

*CAR T-Cell Therapy* 

Encouraging results from clinical trials have continued to fuel the interest in CAR T-cell therapies and our competitors as of the date of this Annual Report include 2seventy bio, Inc., Adicet Bio, Inc, Adaptimmune Therapeutics plc, Affimed NV, Alaunos Therapeutics Inc., Allogene Therapeutics Inc., AlloVir, Inc, Arcellx, Inc., Atara Biotherapeutics, Inc., Autolus Therapeutics plc, Beam Therapeutics Inc., Bellicum Pharmaceuticals, Inc., Caribou Biosciences, Inc., CARsgen Therapeutics Co. Ltd., Cellectis S.A., Cellular Biomedicine Group, Celularity, Inc., Century Therapeutics, Inc., CRISPR Therapeutics, Inc., Editas Medicines, Inc, Fate Therapeutics, Inc., Gracell Biotechnologies Inc., Immatics Biotechnologies GmbH, ImmunityBio, Inc., Intellia Therapeutics, Inc., Juno

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Therapeutics, Inc. (acquired by Celgene Corporation, in turn acquired by Bristol Myers Squibb), Kite Pharma, Inc. (acquired by Gilead Sciences, Inc.), Kuur Therapeutics, Legend Biotech USA, Inc., Lyell Immunopharma, Inc., Medigene AG, Mustang Bio, Inc., NantKwest, Inc., Nkarta Therapeutics, Inc., Novartis AG, Poseida Therapeutics, Inc., Precigen, Inc. Precision Biosciences, Inc., Sana Biotechnology, Inc., Servier Laboratories Limited, Sorrento Therapeutics, Inc., SQZ Biotech, Inc., TC BioPharm Ltd., TCR<sup>2</sup> Therapeutics, Inc., Tmunity Therapeutics, Inc. (acquired by Kite/Gilead), and Ziopharm Oncology, Inc., Cytovia and Takeda.

#### Government Regulation

#### U.S. Regulation
Government authorities in the United States at the federal, state and local level and in other countries extensively regulate, among other things, the research, development, testing, manufacture, quality control, approval, safety, effectiveness, labeling, packaging, storage, record-keeping, promotion, advertising, distribution, post-approval monitoring and reporting, marketing and export and import of drug and biological products, or biologics, such as our product candidates. Generally, before a new drug or biologic can be marketed, considerable data demonstrating its quality, safety and efficacy must be obtained, organized into a format specific for each regulatory authority, submitted for review and an application for marketing authorization must be approved by the regulatory authority. We, along with third-party contractors, will be required to navigate the various nonclinical, clinical and commercial approval requirements of the governing regulatory agencies of the countries in which we wish to conduct studies or seek approval or licensure of our product candidates.

*Regulation of Combination Products in the U.S.* 

Certain products may be comprised of components that are regulated under separate regulatory authorities and by different centers at the FDA. These products are known as combination products. A combination product is comprised of a combination of a drug and a device; a biological product and a device; a drug and a biological product; or a drug, a device, and a biological product. Under regulations issued by the FDA, a combination product includes:

• a product comprised of two or more regulated components that are physically, chemically, or otherwise combined or mixed and produced as a single entity;

• two or more separate products packaged together in a single package or as a unit and comprised of drug and device products, device and biological products, or biological and drug products;

• a drug, device, or biological product packaged separately that according to its investigational plan or proposed labeling is intended for use only with an approved individually specified drug, device or biological product where both are required to achieve the intended use, indication, or effect and where upon approval of the proposed product the labeling of the approved product would need to be changed, e.g., to reflect a change in intended use, dosage form, strength, route of administration, or significant change in dose; or

• any investigational drug, device, or biological packaged separately that according to its proposed labeling is for use only with another individually specified investigational drug, device, or biological product where both are required to achieve the intended use, indication, or effect.

Under the Federal Food, Drug, and Cosmetic Act ("FDCA"), and its implementing regulations, the FDA is charged with assigning a center with primary jurisdiction, or a lead center, for review of a combination product. The designation of a lead center generally eliminates the need to receive approvals from more than one FDA center for combination products, although it does not preclude consultations by the lead center with another FDA center. The determination of which center will be the lead center is based on the "primary mode of action" of the combination product, which means the single mode of action that provides the most important therapeutic action of the combination product, i.e., the mode of action expected to make the greatest contribution to the overall intended therapeutic effects of the combination product. Thus, if the primary mode of action of a device-biologic combination product is

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attributable to the biologic product, that is, if it acts by means of a virus, therapeutic serum, toxin, antitoxin, vaccine, blood, blood component or derivative, allergenic product, or analogous product, the FDA center responsible for premarket review of the biologic product (the Center for Biologics Evaluation and Research, or CBER, would have primary jurisdiction for the combination product. Additionally, the FDA has established an Office of Combination Products to address issues surrounding combination products and provide more certainty to the regulatory review process. That office serves as a focal point for combination product issues for agency reviewers and industry. It is also responsible for developing guidance and regulations to clarify the regulation of combination products, and for assignment of the FDA center that has primary jurisdiction for review of combination products where the jurisdiction is unclear or in dispute.

Following approval of a combination product, each component of a combination product retains its regulatory status (as a biologic or device, for example) and is subject to the requirements established by the FDA for that type of component. Accordingly, under FDA regulations, biologic-device combination products are subject to cGMP requirements applicable to both biologics and devices, including the cGMP requirements for biologics and the FDA's Quality System Regulation applicable to medical devices.

*U.S. Biological Product Development* 

In the United States, the FDA regulates biologics under the FDCA and the Public Health Service Act, or PHSA, and their implementing regulations. Biologics are also subject to other federal, state and local statutes and regulations. The process of obtaining regulatory approvals and the subsequent compliance with appropriate federal, state, local and foreign statutes and regulations require the expenditure of substantial time and financial resources. Failure to comply with the applicable U.S. requirements at any time during the product development process, approval process or after approval, may subject an applicant to administrative or judicial sanctions. These sanctions could include, among other actions, the FDA's refusal to approve pending applications, withdrawal of an approval or license revocation, a clinical hold, untitled or warning letters, product recalls or withdrawals from the market, product seizures, total or partial suspension of production or distribution, injunctions, fines, refusals of government contracts, restitution, disgorgement, or civil or criminal penalties. Any agency or judicial enforcement action could have a material adverse effect on us.

Our product candidates must be approved by the FDA through the Biologics License Application, or BLA, process before they may be legally marketed in the United States. The process required by the FDA before a biologic may be marketed in the United States generally involves the following:

• Completion of extensive nonclinical, sometimes referred to as preclinical, laboratory tests, animal studies and formulation studies in accordance with applicable regulations, including the FDA's Good Laboratory Practice, or GLP, regulations;

• Submission to the FDA of an IND, which must become effective before human clinical trials may begin and must be updated annually or when significant changes are made;

• Performance of adequate and well-controlled human clinical trials in accordance with applicable IND regulations, GCPs, and other clinical trial-related regulations to establish the safety, purity and potency, or efficacy, of the proposed drug product candidate for its proposed indication;

• Preparation and submission to the FDA of a BLA for marketing authorization that includes substantive evidence of safety, purity, and potency from results of nonclinical testing and clinical trials;

• Determination by the FDA within 60 days of its receipt of a BLA to file the application for review;

• Satisfactory completion of an FDA pre-approval inspection of the manufacturing facility or facilities where the product is produced to assess compliance with the FDA's current good manufacturing practices, or cGMPs, requirements to assure that the facilities, methods and controls are adequate to preserve the product's identity, strength, quality, purity and potency;

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• Potential FDA audit of the preclinical study sites and/or clinical trial sites that generated the data in support of the BLA;

• Satisfactory review of the product candidate by an FDA advisory committee, where appropriate and if applicable;

• Payment of user fees for FDA review of the BLA (unless a fee waiver applies); and

• FDA review and approval, or licensure, of the BLA prior to any commercial marketing or sale of the product for particular indications for use in the United States.

Prior to beginning the first clinical trial with a product candidate, we must submit an IND to the FDA. An IND is a request for authorization from the FDA to administer an investigational new drug product to humans. The central focus of an IND submission is on the general investigational plan and the protocol(s) for clinical studies. The IND also includes results of the nonclinical tests, including animal and *in vitro* studies assessing the toxicology, pharmacokinetics, pharmacology, and pharmacodynamic characteristics of the product; chemistry, manufacturing, and controls, or CMC, information; and any available human data or literature to support the use of the investigational product. An IND must become effective before human clinical trials may begin. The IND automatically becomes effective 30 days after receipt by the FDA, unless the FDA places the clinical trial on a clinical hold within the 30-day time period. In such a case, the IND sponsor and the FDA must resolve any outstanding concerns or questions before the clinical trial can begin. The FDA also may impose clinical holds on a biological product candidate at any time before or during clinical trials due to, among other considerations, significant safety concerns or study design deficiencies. Accordingly, we cannot be sure that submission of an IND will result in the FDA allowing a clinical trial to begin, or that, once begun, issues or circumstances will not arise that delay, suspend or terminate such studies.

The clinical stage of development involves the administration of the drug product candidate to healthy volunteers and patients under the supervision of qualified investigators, generally physicians not employed by or under the trial sponsor's control, in accordance with GCPs, which include the requirement that all research subjects provide their informed consent for their participation in any clinical trial. Clinical trials are conducted under protocols detailing, among other things, the objectives of the clinical trial, dosing procedures, subject selection and exclusion criteria, and the parameters to be used to monitor subject safety and assess efficacy. Each protocol, and any subsequent amendments to the protocol, must be submitted to the FDA as part of the IND. Further, each clinical trial must be reviewed and approved by an independent institutional review board, or IRB, at or servicing each institution at which the clinical trial will be conducted. An IRB is charged with protecting the welfare and rights of trial participants and considers such items as whether the risks to individuals participating in the clinical trials are minimized and are reasonable in relation to anticipated benefits. The IRB also approves the informed consent form that must be provided to each clinical trial subject or his or her legal representative and must monitor the clinical trial until completed.

There are also requirements governing the reporting of ongoing clinical trials and completed clinical trial results to public registries. Sponsors of certain clinical trials of FDA-regulated products, including biologics, are required to register and disclose certain clinical trial information, which is publicly available at www.clinicaltrials.gov. Information related to the product, patient population, phase of investigation, study sites and investigators, and other aspects of the clinical trial is then made public as part of the registration. Sponsors are also obligated to discuss the results of their clinical trials after completion. Disclosure of the results of these trials can be delayed until the new product or new indication being studied has been approved. However, in some cases data and other information from trials involving biologics that never garner approval may require disclosure. In addition, publication policies of major medical journals mandate certain registration and disclosures as a pre-condition for potential publication, even if not currently mandated as a matter of law. Competitors may use this publicly available information to gain knowledge regarding the progress of development programs.

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Clinical trials are generally conducted in three sequential phases, known as Phase 1, Phase 2 and Phase 3, and may overlap or be combined. Phase 1 clinical trials generally involve a small number of healthy volunteers who are initially exposed to a single dose and then multiple doses of the drug product candidate. The primary purpose of these clinical trials is to assess the metabolism, pharmacologic action, side effect tolerability and safety of the drug product candidate and, if possible, to gain early evidence on effectiveness. Phase 2 clinical trials typically involve studies in disease-affected patients to determine the dose required to produce the desired benefits. At the same time, safety and further pharmacokinetic and pharmacodynamic information is collected, as well as identification of possible adverse effects and safety risks and preliminary evaluation of efficacy. Multiple Phase 2 clinical trials may be conducted to obtain information prior to beginning Phase 3 trials. Phase 3 clinical trials generally involve large numbers of patients at multiple sites and are designed to provide the data necessary to demonstrate the clinical efficacy of the product for its intended use, its safety in use, and to establish the overall benefit/risk relationship of the product and provide an adequate basis for product approval. Phase 3 clinical trials may include comparisons with placebo and/or other comparator treatments. The duration of treatment is often extended to mimic the actual use of a product during marketing. Generally, two adequate and well-controlled Phase 3 clinical trials are required by the FDA for approval of a BLA.

Post-approval trials, sometimes referred to as Phase 4 clinical trials, may be conducted after initial marketing approval to gain additional information about the product and experience from the treatment of patients in the intended therapeutic indication. In certain instances, FDA may condition approval of a BLA on the sponsor's agreement to conduct additional clinical trials to further assess the biologic's safety and effectiveness after BLA approval.

Progress reports detailing the results of the clinical trials, among other information, must be submitted at least annually to the FDA, and written IND safety reports must be submitted to the FDA and the investigators within 15 calendar days of receipt by the sponsor or its agents after determining that the information qualifies for such expedited reporting. IND safety reports are required for serious and unexpected suspected adverse events, findings from other studies or animal or *in vitro* testing that suggest a significant risk for human subjects, and any clinically important increase in the rate of a serious suspected adverse reaction over that listed in the protocol or investigator brochure. Additionally, a sponsor must notify FDA within 7 calendar days after receiving information concerning any unexpected fatal or life-threatening suspected adverse reaction. Phase 1, Phase 2 and Phase 3 clinical trials may not be completed successfully within any specified period, if at all. The FDA, the IRB, or the sponsor may suspend or terminate a clinical trial at any time on various grounds, including a finding that the research subjects or patients are being exposed to an unacceptable health risk. Similarly, an IRB can suspend or terminate approval of a clinical trial at its institution if the clinical trial is not being conducted in accordance with the IRB's requirements or if the drug has been associated with unexpected serious harm to patients. Additionally, some clinical trials are overseen by an independent group of qualified experts organized by the clinical trial sponsor, known as a data safety monitoring board or committee. This group provides authorization for whether or not a trial may move forward at designated intervals based on access to certain data from the trial. We may also suspend or terminate a clinical trial based on evolving business objectives and/or competitive climate. Concurrent with clinical trials, companies usually complete additional animal studies and must also develop additional information about the chemistry and physical characteristics of the drug product candidate as well as finalize a process for manufacturing the product in commercial quantities in accordance with cGMP requirements. The manufacturing process must be capable of consistently producing quality batches of the drug product candidate and, among other things, must develop methods for testing the identity, strength, quality and purity of the final product. Additionally, appropriate packaging must be selected and tested, and stability studies must be conducted to demonstrate that the drug product candidate does not undergo unacceptable deterioration over its shelf life.

Expanded access, sometimes called "compassionate use," is the use of investigational products outside of clinical trials to treat patients with serious or immediately life-threatening diseases or conditions when there are no comparable or satisfactory alternative treatment options. FDA regulations allow access to investigational products under an IND by the company or the treating physician for treatment purposes on a case-by-case basis for: individual patients (single-patient IND applications for treatment in emergency settings and non-emergency settings); intermediate-size patient populations; and larger populations for use of the investigational product under a treatment protocol or treatment IND application. There is no requirement for a company to provide expanded access to its investigational product. A manufacturer of an investigational drug for a serious disease or condition is required to make publicly available, such as by posting on its website, its policy on evaluating and responding to requests for individual patient access to such investigational drug. This requirement applies on the earlier of the first initiation of a Phase 2 or Phase 3 trial of the investigational drug or, as applicable, 15 days after the drug receives a designation as a breakthrough therapy, fast track product, or regenerative advanced therapy.

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*BLA and FDA Review Process* 

Following trial completion, trial data are analyzed to assess safety and efficacy. The results of preclinical studies and clinical trials are then submitted to the FDA as part of a BLA, along with proposed labeling for the product and information about the manufacturing process and facilities that will be used to ensure product quality, results of analytical testing conducted on the chemistry of the drug product candidate, and other relevant information. The BLA is a request for approval to market the biologic for one or more specified indications and must contain proof of safety, purity, and potency, or efficacy, which is demonstrated by extensive preclinical and clinical testing. The application may include both negative or ambiguous results of preclinical and clinical trials as well as positive findings. Data may come from company-sponsored clinical trials intended to test the safety and efficacy of a use of a product, or from a number of alternative sources, including studies initiated by investigators. To support marketing approval, the data submitted must be sufficient in quality and quantity to establish the safety, purity and potency of the investigational product to the satisfaction of the FDA. FDA approval of a BLA must be obtained before a biologic may be marketed in the United States.

Under the Prescription Drug User Fee Act, or PDUFA, as amended, each BLA must be accompanied by a significant user fee, which is adjusted on an annual basis. PDUFA also imposes an annual prescription drug product program fee. Fee waivers or reductions are available in certain circumstances, including a waiver of the application fee for the first application filed by a small business.

Within 60 days following submission of the application, the FDA reviews a BLA submitted to determine if it is substantially complete before the FDA accepts it for filing. The FDA may refuse to file any BLA that it deems incomplete or not properly reviewable at the time of submission and may request additional information. In this event, the BLA must be resubmitted with the additional information. The resubmitted application also is subject to review before the FDA accepts it for filing. Once a BLA has been accepted for filing, the FDA's goal is to review BLAs within 10 months of the filing date for standard review under the Prescription Drug User Fee Act ("PDUFA") or six months of the filing date for priority review, if the application is for a product intended for a serious or life-threatening condition and the product, if approved, would provide a significant improvement in safety or effectiveness. In both standard and priority reviews, the FDA does not always meet its PDUFA goal dates, and the review process is often significantly extended by FDA requests for additional information or clarification.

After the BLA submission is accepted for filing, the FDA reviews the BLA to determine, among other things, whether the proposed drug product candidate is safe, pure and potent for its intended use, and whether the drug product candidate is being manufactured in accordance with cGMP to assure and preserve the drug product candidate's identity, strength, quality, purity and potency. The FDA may refer applications for novel product candidates or product candidates which present difficult questions of safety or efficacy to an advisory committee, typically a panel that includes clinicians and other experts, for review, evaluation and a recommendation as to whether the application should be approved and under what conditions. The FDA is not bound by the recommendations of an advisory committee, but it considers such recommendations carefully when making decisions. The FDA will likely re-analyze the clinical trial data, which could result in extensive discussions between the FDA and us during the review process. The review and evaluation of a BLA by the FDA is extensive and time consuming and may take longer than originally planned to complete, and we may not receive a timely approval, if at all.

Before approving a BLA, the FDA will conduct a pre-approval inspection of the manufacturing facilities for the new product. The FDA will not approve the product unless it determines that the manufacturing processes and facilities are in compliance with cGMP requirements and adequate to assure consistent production of the product within required specifications. In addition, before approving a BLA, the FDA may also audit data from clinical trials to ensure compliance with GCP requirements. After the FDA evaluates the application, manufacturing process and manufacturing facilities, it may issue an approval letter or a Complete Response Letter. An approval letter authorizes commercial marketing of the product with specific prescribing information for specific indications. A Complete Response Letter indicates that the review cycle of the application is complete, and the application will not be approved in its present form. A Complete Response Letter usually describes all of the specific deficiencies in the BLA identified by the FDA. The Complete Response Letter may require additional clinical data and/or an additional pivotal Phase 3 clinical trial(s), and/or other significant and time-consuming requirements related to clinical trials, preclinical studies or manufacturing. If a Complete Response Letter is issued, the applicant may either resubmit the BLA, addressing all of the deficiencies identified in the letter, withdraw the application or request a hearing. Even if such data and information is submitted, the FDA may ultimately decide that the BLA does not satisfy the criteria for approval. Data obtained from clinical trials are not always conclusive, and the FDA may interpret data differently than we interpret the same data.

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There is no assurance that the FDA will ultimately approve a product for marketing in the United States, and we may encounter significant difficulties or costs during the review process. If a product receives marketing approval, the approval may be significantly limited to specific populations, and dosages or the indications for use may otherwise be limited, which could restrict the commercial value of the product. Further, the FDA may require that certain contraindications, warnings or precautions be included in the product labeling or may condition the approval of the BLA on other changes to the proposed labeling, development of adequate controls and specifications, or a commitment to conduct post-market testing or clinical trials and surveillance to monitor the effects of approved products. For example, the FDA may require Phase 4 testing which involves clinical trials designed to further assess the product's safety and effectiveness and may require testing and surveillance programs to monitor the safety of approved products that have been commercialized. The FDA may also place other conditions on approvals including the requirement for a Risk Evaluation and Mitigation Strategy, or REMS, to assure the safe use of the product. If the FDA concludes a REMS is needed, the sponsor of the BLA must submit a proposed REMS. The FDA will not approve the BLA without an approved REMS, if required. A REMS could include medication guides, physician communication plans, or elements to assure safe use, such as restricted distribution methods, patient registries and other risk minimization tools. Any of these limitations on approval or marketing could restrict the commercial promotion, distribution, prescription or dispensing of products. Product licenses may be revoked or suspended for non-compliance with regulatory standards or if problems occur following initial marketing.

*Expedited Development and Review Programs* 

*Fast Track Designation* 

The FDA has a Fast Track program that is intended to expedite or facilitate the process for reviewing new drugs and biological products that meet certain criteria. Specifically, new drugs and biological products are eligible for Fast Track designation if they are intended to treat a serious or life-threatening condition and nonclinical or clinical data demonstrate the potential to address unmet medical needs for the condition. Fast Track designation applies to the combination of the product and the specific indication for which it is being studied. The sponsor of a new drug or biologic may request the FDA to designate the drug or biologic as a Fast Track product concurrently with, or at any time after, submission of an IND, and the FDA must determine if the product qualifies for Fast Track designation within 60 days of receipt of the sponsor's request. The FDA may consider for review sections of the marketing application on a rolling basis before the complete application is submitted, if the sponsor provides a schedule for the submission of the sections of the application, the FDA agrees to accept sections of the application and determines that the schedule is acceptable, and the sponsor pays any required user fees upon submission of the first section of the application.

*Priority Review* 

Any product submitted to the FDA for marketing, including under a Fast Track program, may be eligible for other types of FDA programs intended to expedite development and review, such as priority review and accelerated approval. Any product is eligible for priority review, or review within a six-month timeframe from the date a complete BLA is accepted for filing, if it has the potential to provide a significant improvement in safety and effectiveness compared to available therapies. The FDA will attempt to direct additional resources to the evaluation of an application for a new drug or biological product designated for priority review in an effort to facilitate the review.

*Accelerated Approval* 

Additionally, a product may be eligible for accelerated approval. An investigational drug may obtain accelerated approval if it treats a serious or life-threatening condition and generally provides a meaningful advantage over available therapies and demonstrates an effect on a surrogate endpoint that is reasonably likely to predict clinical benefit or on a clinical endpoint that can be measured earlier than irreversible morbidity or mortality, or IMM, that is reasonably likely to predict an effect on IMM or other clinical benefit. As a condition of approval, the FDA generally requires that a sponsor of a drug or biological product receiving accelerated approval perform, in a diligent manner, adequate and well-controlled post-marketing clinical trials to verify the clinical benefit in relationship to the surrogate endpoint or ultimate outcome in relationship to the clinical benefit. Under FDORA, the FDA may require, as appropriate, that such trials be underway prior to approval or within a specific time period after the date of approval for a product granted accelerated approval. If the FDA concludes that a drug shown to be effective can be safely used only if distribution or use is restricted, it will require such post-marketing restrictions as it deems necessary to assure safe use of the drug, such as:

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• Distribution restricted to certain facilities or physicians with special training or experience; or

• Distribution conditioned on the performance of specified medical procedures.

The limitations imposed would be commensurate with the specific safety concerns presented by the product. In addition, the FDA currently requires unless otherwise informed by the agency, pre-approval of promotional materials for products receiving accelerated approval, which could adversely impact the timing of the commercial launch of the product. Under FDORA, the FDA has increased authority for expedited procedures to withdraw approval of a drug, or an indication approved under accelerated approval if, for example, the confirmatory trial fails to verify the predicted clinical benefit of the product. Fast Track designation, priority review and accelerated approval do not change the standards for approval but may expedite the development or approval process.

*Breakthrough Therapy Designation* 

A product can be designated as a breakthrough therapy if it is intended to treat a serious or life-threatening condition and preliminary clinical evidence indicates that it may demonstrate substantial improvement over existing therapies on one or more clinically significant endpoints. A sponsor may request that a drug product candidate be designated as a breakthrough therapy concurrently with, or at any time after, the submission of an IND, and the FDA must determine if the drug product candidate qualifies for breakthrough therapy designation within 60 days of receipt of the sponsor's request. If so designated, the FDA shall act to expedite the development and review of the product's marketing application, including by meeting with the sponsor throughout the product's development, providing timely advice to the sponsor to ensure that the development program to gather preclinical and clinical data is as efficient as practicable, involving senior managers and experienced review staff in a cross-disciplinary review, assigning a cross-disciplinary project lead for the FDA review team to facilitate an efficient review of the development program and to serve as a scientific liaison between the review team and the sponsor, and reviewing portions of the marketing application on a rolling basis before the sponsor submits the complete application.

*Accelerated Approval for Regenerative Advanced Therapies* 

As part of the 21st Century Cures Act, Congress amended the FDCA to create an accelerated approval program for products designated as regenerative medicine advanced therapies, which include cell therapies, therapeutic tissue engineering products, human cell and tissue products, and combination products using any such therapies or products. Regenerative medicine advanced therapies do not include those human cells, tissues, and cellular and tissue-based products regulated solely under section 361 of the PHSA and 21 CFR Part 1271. The new program is intended to facilitate efficient development and expedite review of regenerative medicine advanced therapies, which are intended to treat, modify, reverse, or cure a serious or life-threatening disease or condition. A drug sponsor may request that FDA designate a drug as a regenerative medicine advanced therapy concurrently with or at any time after submission of an IND. FDA has 60 calendar days to determine whether the drug meets the criteria, including whether there is preliminary clinical evidence indicating that the drug has the potential to address unmet medical needs for a serious or life-threatening disease or condition. A new drug application or BLA for a regenerative medicine advanced therapy may be eligible for priority review or accelerated approval through (1) previously agreed-upon surrogate or intermediate endpoints reasonably likely to predict long-term clinical benefit or (2) reliance upon data obtained from a meaningful number of sites. Benefits of such designation also include early interactions with FDA to discuss any potential surrogate or intermediate endpoint to be used to support accelerated approval. A regenerative medicine advanced therapy that is granted accelerated approval and is subject to post-approval requirements may fulfill such requirements through the submission of clinical evidence, clinical studies, patient registries, or other sources of real-world evidence, such as electronic health records; the collection of larger confirmatory data sets; or post-approval monitoring of all patients treated with such therapy prior to its approval.

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*Orphan Drug Designation and Exclusivity* 

Under the Orphan Drug Act, the FDA may grant orphan drug designation to a drug or biological product intended to treat a rare disease or condition, which is generally a disease or condition that affects fewer than 200,000 individuals in the United States, or 200,000 or more individuals in the United States and for which there is no reasonable expectation that the cost of developing and making a drug or biological product available in the United States for this type of disease or condition will be recovered from sales of the product. Orphan drug designation must be requested before submitting a BLA. After the FDA grants orphan drug designation, the identity of the therapeutic agent and its potential orphan use are disclosed publicly by the FDA. Orphan drug designation does not convey any advantage in or shorten the duration of the regulatory review and approval process.

If a product that has orphan drug designation subsequently receives the first FDA approval for a particular active ingredient for the disease for which it has such designation, the product is entitled to orphan product exclusivity, which means that the FDA may not approve any other applications, including a full BLA, to market the same biologic for the same indication for seven years, except in limited circumstances, such as a showing of clinical superiority to the product with orphan drug exclusivity or if the FDA finds that the holder of the orphan drug exclusivity has not shown that it can assure the availability of sufficient quantities of the orphan drug to meet the needs of patients with the disease or condition for which the drug was designated. Orphan drug exclusivity does not prevent the FDA from approving a different drug or biologic for the same disease or condition, or the same drug or biologic for a different disease or condition. Among the other benefits of orphan drug designation are tax credits for certain research and a waiver of the BLA application user fee. A designated orphan drug may not receive orphan drug exclusivity if it is approved for a use that is broader than the indication for which it received orphan designation. In addition, orphan drug exclusive marketing rights in the United States may be lost if the FDA later determines that the request for designation was materially defective or, as noted above, if the second applicant demonstrates that its product is clinically superior to the approved product with orphan exclusivity, or the manufacturer of the approved product is unable to assure sufficient quantities of the product to meet the needs of patients with the rare disease or condition.

*Platform Technology Designation* 

Under FDORA, a platform technology incorporated within or utilized by a biological product is eligible for designation as a designated platform technology if (1) the platform technology is incorporated in, or utilized by, a biologic product approved under a BLA; (2) preliminary evidence submitted by the sponsor of the approved or licensed biologic product, or a sponsor that has been granted a right of reference to data submitted in the application for such biologic product, demonstrates that the platform technology has the potential to be incorporated in, or utilized by, more than one biologic product without an adverse effect on quality, manufacturing, or safety; and (3) data or information submitted by the applicable person indicates that incorporation or utilization of the platform technology has a reasonable likelihood to bring significant efficiencies to the drug development or manufacturing process and to the review process. A sponsor may request the FDA to designate a platform technology as a designated platform technology concurrently with, or at any time after, submission of an IND application for a biologic product that incorporates or utilizes the platform technology that is the subject of the request. If so designated, the FDA may expedite the development and review of any subsequent original BLA for a biological product that uses or incorporates the platform technology. Designated platform technology status does not ensure that a biological product will be developed more quickly or receive FDA approval. In addition, the FDA may revoke a designation if the FDA determines that a designated platform technology no longer meets the criteria for such designation.

*Pediatric Trials* 

Under the Pediatric Research Equity Act, or PREA, as amended, a BLA or supplement to a BLA must contain data to assess the safety and efficacy of the product for the claimed indications in all relevant pediatric subpopulations and to support dosing and administration for each pediatric subpopulation for which the product is safe and effective. The FDCA requires that a sponsor who is planning to submit a marketing application for a drug or biological product that includes a new active ingredient, new indication, new dosage form, new dosing regimen or new route of administration submit an initial Pediatric Study Plan, or PSP, within sixty days of an end-of-Phase II meeting or as may be agreed between the sponsor and FDA. The initial PSP must include an outline of the pediatric study or studies that the sponsor

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plans to conduct, including study objectives and design, age groups, relevant endpoints and statistical approach, or a justification for not including such detailed information, and any request for a deferral of pediatric assessments or a full or partial waiver of the requirement to provide data from pediatric studies along with supporting information. FDA and the sponsor must reach agreement on the PSP. A sponsor can submit amendments to an agreed-upon initial PSP at any time if changes to the pediatric plan need to be considered based on data collected from nonclinical studies, early phase clinical trials, and/or other clinical development programs. The FDA may, on its own initiative or at the request of the applicant, grant deferrals for submission of data or full or partial waivers.

*Post-Marketing Requirements* 

Following approval of a new product, a manufacturer and the approved product are subject to continuing regulation by the FDA, including, among other things, monitoring and recordkeeping activities, reporting to the applicable regulatory authorities of adverse experiences with the product, providing the regulatory authorities with updated safety and efficacy information, product sampling and distribution requirements, and complying with promotion and advertising requirements, which include, among others, standards for direct-to-consumer advertising, restrictions on promoting products for uses or in patient populations that are not described in the product's approved labeling (known as "off-label use"), limitations on industry-sponsored scientific and educational activities, and requirements for promotional activities involving the internet. Although physicians may prescribe legally available drugs and biologics for off-label uses, manufacturers may not market or promote such off-label uses.

Modifications or enhancements to the product or its labeling or changes of the site of manufacture are often subject to the approval of the FDA and other regulators, which may or may not be received or may result in a lengthy review process. Prescription drug promotional materials must be submitted to the FDA in conjunction with their first use. Any distribution of prescription drug products and pharmaceutical samples must comply with the U.S. Prescription Drug Marketing Act, or the PDMA, a part of the FDCA.

In the United States, once a product is approved, its manufacture is subject to comprehensive and continuing regulation by the FDA. The FDA regulations require that products be manufactured in specific approved facilities and in accordance with cGMPs. The cGMP requirements for constituent parts of cross-labeled combination products that are manufactured separately and not co-packaged are the same as those that would apply if these constituent parts were not part of a combination product. For single-entity and co-packaged combination products, there are two ways to demonstrate compliance with cGMP requirements, either compliance with all cGMP regulations applicable to each of the constituent parts included in the combination product, or a streamlined approach demonstrating compliance with either the drug/biologic cGMPs or the medical device quality system regulation rather than demonstrating full compliance with both, under certain conditions. These conditions include demonstrating compliance with specified provisions from the other of these two sets of cGMP requirements. We rely, and expect to continue to rely, on third parties for the production of clinical and commercial quantities of our products in accordance with cGMP regulations. cGMP regulations require, among other things, quality control and quality assurance as well as the corresponding maintenance of records and documentation and the obligation to investigate and correct any deviations from cGMP. Manufacturers and other entities involved in the manufacture and distribution of approved products are required to register their establishments with the FDA and certain state agencies, and are subject to periodic unannounced inspections by the FDA and certain state agencies for compliance with cGMP and other laws. Manufacturers and other parties involved in the drug supply chain for prescription drug products must also comply with product tracking and tracing requirements and for notifying the FDA of counterfeit, diverted, stolen and intentionally adulterated products or products that are otherwise unfit for distribution in the United States. Accordingly, manufacturers must continue to expend time, money, and effort in the area of production and quality control to maintain cGMP compliance. These regulations also impose certain organizational, procedural and documentation requirements with respect to manufacturing and quality assurance activities. BLA holders using contract manufacturers, laboratories or packagers are responsible for the selection and monitoring of qualified firms, and, in certain circumstances, qualified suppliers to these firms. These firms and, where applicable, their suppliers are subject to inspections by the FDA at any time, and the discovery of violative conditions, including failure to conform to cGMP, could result in enforcement actions that interrupt the operation of any such facilities or the ability to distribute products manufactured, processed or tested by them. Discovery of problems with a product after approval may result in restrictions on a product, manufacturer, or holder of an approved BLA, including, among other things, recall or withdrawal of the product from the market.

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The FDA also may require post-approval testing, sometimes referred to as Phase 4 testing, risk minimization action plans and post-marketing surveillance to monitor the effects of an approved product or place conditions on an approval that could restrict the distribution or use of the product. Discovery of previously unknown problems with a product or the failure to comply with applicable FDA requirements can have negative consequences, including adverse publicity, judicial or administrative enforcement, untitled or warning letters from the FDA, mandated corrective advertising or communications with doctors, and civil or criminal penalties, among others. Newly discovered or developed safety or effectiveness data may require changes to a product's approved labeling, including the addition of new warnings and contraindications, and also may require the implementation of other risk management measures. Also, new government requirements, including those resulting from new legislation, may be established, or the FDA's policies may change, which could delay or prevent regulatory approval of our products under development.

*Other Regulatory Matters* 

Manufacturing, sales, promotion and other activities following product approval are also subject to regulation by numerous regulatory authorities in addition to the FDA, including, in the United States, the Centers for Medicare & Medicaid Services, or CMS, other divisions of the Department of Health and Human Services, the Drug Enforcement Administration, the Consumer Product Safety Commission, the Federal Trade Commission, the Occupational Safety & Health Administration, the Environmental Protection Agency and state and local governments. In the United States, sales, marketing and scientific/educational programs must also comply with federal and state fraud and abuse laws, data privacy and security laws, transparency laws, and pricing and reimbursement requirements in connection with governmental payor programs, among others. The handling of any controlled substances must comply with the U.S. Controlled Substances Act and Controlled Substances Import and Export Act. Products must meet applicable child-resistant packaging requirements under the U.S. Poison Prevention Packaging Act. Manufacturing, sales, promotion and other activities are also potentially subject to federal and state consumer protection and unfair competition laws.

The distribution of pharmaceutical products is subject to additional requirements and regulations, including extensive record-keeping, licensing, storage and security requirements intended to prevent the unauthorized sale of pharmaceutical products.

The failure to comply with regulatory requirements subjects firms to possible legal or regulatory action. Depending on the circumstances, failure to meet applicable regulatory requirements can result in criminal prosecution, fines or other penalties, injunctions, recall or seizure of products, total or partial suspension of production, denial of product approvals, license suspension or revocation, or refusal to allow a firm to enter into supply contracts, including government contracts. In addition, even if a firm complies with FDA and other requirements, new information regarding the safety or efficacy of a product could lead the FDA to modify or suspend or revoke licenses. Prohibitions or restrictions on sales or withdrawal of future products marketed by us could materially affect our business in an adverse way.

Changes in regulations, statutes or the interpretation of existing regulations could impact our business in the future by requiring, for example: (i) changes to our manufacturing arrangements; (ii) additions or modifications to product labeling; (iii) the recall or discontinuation of our products; or (iv) additional record-keeping requirements. If any such changes were to be imposed, they could adversely affect the operation of our business.

*U.S. Patent Term Restoration and Marketing Exclusivity* 

Depending upon the timing, duration and specifics of the FDA approval of our product candidates, some of our U.S. patents may be eligible for limited patent term extension under the Drug Price Competition and Patent Term Restoration Act of 1984, commonly referred to as the Hatch-Waxman Amendments. The Hatch-Waxman Amendments permit a patent restoration term of up to five years as compensation for patent term lost during product development and the FDA regulatory review process. However, patent term restoration cannot extend the remaining term of a patent beyond a total of 14 years from the product's approval date. The patent term restoration period is generally one-half the time between the effective date of an IND and the submission date of a BLA plus the time between the submission date of a BLA and the approval of that application, except that the review period is reduced by any time during which the applicant failed to exercise due diligence. Only one patent applicable to an approved drug is eligible for the extension and the application for the extension must be submitted prior to the expiration of the patent. The U.S. PTO, in consultation with the FDA, reviews and approves the application for any patent term extension or restoration. In the future, we may apply for restoration of patent term for our currently owned or licensed patents to add patent life beyond its current expiration date, depending on the expected length of the clinical trials and other factors involved in the filing of the relevant BLA.

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A reference biological product is granted twelve years of exclusivity from the time of first licensure of the product, and the FDA will not accept an application for a biosimilar or interchangeable product based on the reference biological product until four years after first licensure. The FDA may approve multiple "first" interchangeable products so long as they are all approved on the same first day of marketing. "First licensure" typically means the initial date the particular product at issue was licensed in the United States. This does not include a supplement for the biological product or a subsequent application by the same sponsor or manufacturer of the biological product (or licensor, predecessor in interest, or other related entity) for a change that results in a new indication, route of administration, dosing schedule, dosage form, delivery system, delivery device, or strength, unless that change is a modification to the structure of the biological product and such modification changes its safety, purity, or potency. Whether a subsequent application, if approved, warrants exclusivity as the "first licensure" of a biological product is determined on a case-by-case basis with data submitted by the sponsor.

Pediatric exclusivity is another type of regulatory market exclusivity in the United States. Pediatric exclusivity, if granted, adds six months to existing exclusivity periods and patent terms. This six-month exclusivity, which attaches to the twelve-year exclusivity period for reference biologics, may be granted based on the voluntary completion of a pediatric trial in accordance with an FDA-issued "Written Request" for such a trial.

#### European Union Drug Development
In the EU, our future product candidates will also be subject to extensive regulatory requirements. As in the United States, medicinal products can only be marketed if a marketing authorization, or MA, from the competent regulatory agencies has been obtained.

*Clinical Trials Approval* 

In April 2014, the EU adopted the new Clinical Trials Regulation, (EU) No. 536/2014, or Regulation, which replaced the current Clinical Trials Directive 2001/20/EC, or Directive, on 31 January 2022. The Regulation is directly applicable in all EU Member States meaning no national implementing legislation in each EU Member State is required. The new Regulation aims at harmonizing and streamlining the clinical trials authorization process, simplifying adverse event reporting procedures, improving the supervision of clinical trials, and increasing their transparency. The new Regulation brings about a new Clinical Trials Information System (CTIS), which is a single entry point for sponsors and regulators of clinical trials for the submission and assessment of clinical trial data and enables a sponsor to apply for authorizations in up to 30 EU countries at the same time and with the same documentation, In addition, the transitory provisions of the new Regulation offer the sponsor the possibility to choose between the requirements of the Directive and the Regulation if the request for authorization of a clinical trial is submitted in the 12 months after the new Regulation became applicable. In that case, the clinical trial continues to be governed by the Directive until three years after the new Regulation became applicable.

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*Drug Review and Approval* 

In the EU, medicinal products can only be commercialized after obtaining a marketing authorization, or MA.

Following positive completion of clinical trials, pharmaceutical companies can submit an MA application. The MA application shall include all information that is relevant to the evaluation of the medicinal products, whether favorable or unfavorable. The application dossier must include, among other things, the results of pharmaceutical (physicochemical, biological, or microbiological) tests, preclinical (toxicological and pharmacological) tests, and clinical trials, including the therapeutic indications, contra-indications, and adverse reactions, and the recommended dosing regimen or posology.

In addition to demonstrating the safety and efficacy of the medicinal product, pharmaceutical companies are required to guarantee the consistent quality of the product. Therefore, the conditions for obtaining an MA include requirements that the manufacturer of the product complies with applicable legislation including Good Manufacturing Practice, or GMP, related implementing measures and applicable guidelines that involve, amongst others, ongoing inspections of manufacturing and storage facilities. There are two types of marketing authorizations in the EU:

The centralized MA, which is issued by the European Commission through the centralized procedure, based on the opinion of the Committee for Medicinal Products for Human Use, or CHMP, of the European Medicines Agency, or EMA, and which is valid throughout the EU, and in the additional Member States of the European Economic Area (Iceland, Liechtenstein and Norway). The centralized procedure is mandatory for certain types of products, including for medicinal products derived from biotechnological processes, products designated as orphan medicinal products, advanced-therapy medicines (gene-therapy, somatic cell-therapy or tissue-engineered medicines), and medicinal products containing a new active substance indicated for the treatment of HIV, AIDS, cancer, neurodegenerative disorders, diabetes, auto-immune and other immune dysfunctions, and viral diseases. The centralized procedure is optional for products containing a new active substance not yet authorized in the EU, or for products that constitute a significant therapeutic, scientific or technical innovation or which is in the interest of public health in the EU.

National MAs, which are issued by the competent authorities of the EU Member States and only cover their respective territory, are available for products not falling within the mandatory scope of the centralized procedure. Where a product has already been authorized for marketing in an EU Member State, this national MA can be recognized in other Member State(s) through the mutual recognition procedure, or MRP. If the product has not received a national MA in any Member State at the time of application, it can be approved simultaneously in various Member States through the decentralized procedure, or DCP. Under the DCP an identical dossier is submitted to the competent authorities of each of the Member States in which the MA is sought, one of which is selected by the applicant as the Reference Member State, or RMS. The competent authority of the RMS prepares a draft assessment report, a draft summary of product characteristics, or SmPC, and a draft of the labeling and package leaflet, which are sent to the other Member States (referred to as the Concerned Member States, or CMSs) for their approval. If the CMSs raise no objections, based on a potential serious risk to public health, to the assessment, SmPC, labeling, or packaging proposed by the RMS, the product is subsequently granted a national MA in all the relevant Member States (i.e., in the RMS and the CMSs).

Under the above-described procedures, before granting the MA, the EMA or the competent authorities of the Member States of the EU make an assessment of the risk-benefit balance of the product on the basis of scientific criteria concerning its quality, safety and efficacy.

Now that the UK (which comprises Great Britain and Northern Ireland) has left the EU, Great Britain will no longer be covered by centralized MAs (under the Northern Ireland Protocol, centralized MAs will continue to be recognized in Northern Ireland). All medicinal products with a current centralized MA were automatically converted to Great Britain MAs on January 1, 2021. For a period of two years from January 1, 2021, the Medicines and Healthcare products Regulatory Agency, or MHRA, the UK medicines regulator, may rely on a decision taken by the European Commission on the approval of a new marketing authorization in the centralized procedure, in order to more quickly grant a new Great Britain MA. A separate application will, however, still be required.

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*Early Access Mechanisms* 

Several schemes exist in the EU to support earlier access to new medicines falling within the scope of the centralized procedure, in particular (i) accelerated assessment; (ii) conditional MAs; and (iii) MAs granted under exceptional circumstances.

For a medicine, which is of "major public health interest" (in particular, in terms of therapeutic innovation), accelerated assessment can be requested, taking up to 150 days instead of the usual period of up to 210 days (although in each case "clock stops", where additional information or written or oral explanation is to be provided by the applicant in response to questions asked by the CHMP, may extend the timeframe of the assessment beyond 150 or 210 days (as applicable)). There is no single definition of what constitutes "major public health interest". This should be justified by the applicant on a case-by-case basis. The justification should present arguments to support the claim that the medicinal product introduces new methods of therapy or improves on existing methods, thereby addressing to a significant extent the greater unmet needs for maintaining and improving public health.

A conditional marketing authorization is granted prior to obtaining the comprehensive clinical data required for an application for a full marketing authorization. Such conditional marketing authorizations may be granted for product candidates intended for treating, preventing or diagnosing seriously debilitating or life-threatening diseases (including medicines designated as orphan medicinal products), if (i) the risk-benefit balance of the product candidate is positive, (ii) it is likely that the applicant will be in a position to provide the required comprehensive clinical trial data post-authorization, (iii) the product fulfills an unmet medical need and (iv) the benefit to public health of the immediate availability on the market of the medicinal product concerned outweighs the risk inherent in the fact that additional data are still required. A conditional marketing authorization may contain specific obligations to be fulfilled by the marketing authorization holder, including obligations with respect to the completion of ongoing or new studies, and with respect to the collection of pharmacovigilance data. Conditional marketing authorizations are valid for one year, and may be renewed annually, if the risk-benefit balance remains positive, and after an assessment of the need for additional or modified conditions and/or specific obligations. The timelines for the centralized procedure described above also apply with respect to the review by the CHMP of applications for a conditional marketing authorization. A conditional marketing authorization can be converted into a standard centralized marketing authorization (no longer subject to specific obligations) once the marketing authorization holder fulfils the obligations imposed and the complete data confirm that the medicine's benefits continue to outweigh its risks.

Medicines for which the MA applicant can demonstrate that the normally required comprehensive efficacy and safety data cannot be provided (for example because the disease which the medicine treats is extremely rare) may be eligible for an MA under exceptional circumstances. These are medicines for which it is not normally intended that a full MA will be obtained. Where an MA under exceptional circumstances is granted, it will be subject to a requirement for the applicant to introduce specific procedures, in particular in relation to the safety of the medicine, notification to competent regulatory authorities of any incident relating to its use, and the action to be taken in such circumstances. MAs under exceptional circumstances are reviewed annually to reassess the risk-benefit balance.

*Supplementary Protection Certificates and Data/market Exclusivity* 

In the EU, the extension of effective patent term to compensate originator pharmaceutical companies for the period between the filing of an application for a patent for a new medicinal product and the first MA for such product, has been achieved by means of a Supplementary Protection Certificate, or SPC, which can be applied for by the originator pharmaceutical company within six months from the granting of the first MA and comes into effect on expiry of the basic patent. Such SPC attaches only to the active ingredient of the medicinal product for which the MA has been granted. The SPC for an active ingredient has a single last potential expiry date throughout the EU and cannot last for more than five years from the date on which it takes effect (*i.e.*, patent expiry). Furthermore, the overall duration of protection afforded by a patent and a SPC cannot exceed 15 years from the first MA. The duration of a medicinal product SPC can be extended by a single six-month period, or pediatric extension, when all studies in accordance with a pediatric investigation plan, or PIP, have been carried out.

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Innovative medicines benefit from specific data and marketing exclusivity regimes. These regimes are intended to provide general regulatory protection to further stimulate innovation. The current rules provide for (i) an 8-year data exclusivity period (from the grant of the MA of an innovative medicine) which prevents the filing of an abridged (generic or biosimilar) application for a follow-on product, which references the data supporting the MA of the innovative medicine (data exclusivity); and (ii) an additional 2-year period of protection against the marketing of a follow-on product (marketing exclusivity), with a possible extension by 1 year if, during the first 8 years, a new therapeutic indication (which is considered to bring a significant clinical benefit in comparison with existing therapies) is approved. This protection is often referred to as the "eight, plus two, plus one" rule. Additional reward mechanisms exist, most notably a 10-year orphan medicines' marketing exclusivity, and a 1-year data exclusivity for developing a new indication for an old substance and for switch data supporting a change in prescription status.

The current rules also provide for a system of obligations and rewards and incentives intended to facilitate the development and accessibility of pediatric medicinal products, and to ensure that such products are subject to high quality ethical research.

*Orphan Designation and Exclusivity* 

Regulation (EC) No. 141/2000, as implemented by Regulation (EC) No. 847/2000 provides that a product can be designated as an orphan medicinal product by the European Commission if its sponsor can establish: that (1) the product is intended for the diagnosis, prevention or treatment of a life-threatening or chronically debilitating condition; (2) either (a) such condition affects no more than five (5) in ten thousand (10,000) persons in the EU when the application is made, or (b) it is unlikely that the product, without the benefits derived from orphan status, would generate sufficient return in the EU to justify the necessary investment in its development; and (3) there exists no satisfactory method of diagnosis, prevention or treatment of such condition authorized for marketing in the EU or, if such method exists, the product will be of significant benefit to those affected by that condition. Orphan medicinal products are eligible for financial incentives such as reduction of fees or fee waivers. The application for orphan designation must be submitted before the application for marketing authorization. The applicant will receive a fee reduction for the marketing authorization application if the orphan designation has been granted, but not if the designation is still pending at the time the marketing authorization is submitted. Orphan designation does not convey any advantage in, or shorten the duration of, the regulatory review and approval process.

Products receiving orphan designation in the EU can receive ten years of market exclusivity, during which time no "similar medicinal product" may be placed on the market. A "similar medicinal product" is defined as a medicinal product containing a similar active substance or substances as contained in an authorized orphan medicinal product, and which is intended for the same therapeutic indication.

However, marketing authorization may be granted to a similar medicinal product with the same orphan indication during the ten-year period with the consent of the marketing authorization holder for the original orphan medicinal product or if the manufacturer of the original orphan medicinal product is unable to supply sufficient quantities. Marketing authorization may also be granted to a similar medicinal product with the same orphan indication if the similar product is safer, more effective or otherwise clinically superior to the original orphan medicinal product. The period of market exclusivity may, in addition, be reduced to six years if, at the end of the fifth year, it is established that the product no longer meets the criteria for orphan designation, for example, if the product is sufficiently profitable not to justify maintenance of market exclusivity.

*Post-marketing and Pharmacovigilance Requirements* 

When granting an MA, competent authorities (*i.e.*, the EMA or the relevant national competent authorities) may impose an obligation to conduct additional clinical testing, sometimes referred to as Phase IV clinical trials, or other post-approval commitments, to monitor the product after commercialization. Additionally, the MA may be subjected to limitations on the indicated uses for the product.

Also, after an MA has been obtained, the marketed product and its manufacturer and MA holder will continue to be subject to a number of regulatory obligations, as well as to monitoring/inspections by the competent authorities.

Under applicable pharmacovigilance rules, pharmaceutical companies must, in relation to all their authorized products, irrespective of the regulatory route of approval, collect, evaluate and collate information concerning all suspected adverse reactions and, when relevant, report it to the competent authorities. This information includes both suspected adverse reactions signaled by healthcare professionals, either spontaneously or through post-authorization studies, regardless of whether or not the medicinal product was used in accordance with the authorized SmPC and/or any other

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marketing conditions, and suspected adverse reactions identified in worldwide-published scientific literature. To that end, an MA holder must have (permanently and continuously) at its disposal an appropriately qualified person responsible for pharmacovigilance and establish an adequate pharmacovigilance system. All relevant suspected adverse reactions, including suspected serious adverse reactions, which must also be reported on an expedited basis, should be submitted to the competent authorities in the form of Periodic Safety Update Reports, or PSURs. PSURs are intended to provide an update for the competent authorities on the worldwide safety experience of a medicinal product at defined time points after authorization. PSURs must therefore comprise a succinct summary of information together with a critical evaluation of the risk/benefit balance of the medicinal product, taking into account any new or changing information. The evaluation should ascertain whether any further investigations need to be carried out, and whether the SmPC or other product information needs to be modified.

To ensure that pharmaceutical companies comply with pharmacovigilance regulatory obligations, and to facilitate compliance, competent authorities will conduct pharmacovigilance inspections. These inspections are either routine (*i.e.,* aimed at determining whether the appropriate personnel, systems, and resources are in place) or "for cause" (*i.e.,* targeted to companies suspected of being non-compliant, or in response to specific issues arising where there is a potential for increased risk of non-compliance). Reports of the outcome of such inspections will be used to help improve compliance and may also be used as a basis for enforcement action.

*Other Regulatory Matters* 

Advertising of medicines is subject to tighter controls than general consumer goods and specific requirements are set forth in Directive 2001/83/EC (as implemented in each EU Member State), which apply in addition to the general rules. In general, advertising of unapproved medicinal products or of unapproved uses of otherwise authorized medicinal products (*e.g.*, off-label uses) is prohibited, and advertising for prescription medicinal products must be directed only towards health care professionals (*i.e.*, advertising of these products to the general public is prohibited). Member States have implemented the advertising rules differently and the requirements vary significantly depending on the specific country. Advertising of medicinal products in an online setting, including social media, can be particularly challenging given the strict rules in place. Such prohibitions on advertising have been implemented into UK law through the Human Medicines Regulations 2012, and therefore will continue to apply in the UK despite its departure from the EU.

The manufacturing of authorized medicinal products, for which a separate manufacturer's license is mandatory, must also be conducted in strict compliance with the applicable EU laws, regulations and guidance, including Directive 2001/83/EC, Directive 2003/94/EC, Regulation (EC) No 726/2004 and the European Commission Guidelines for Good Manufacturing Practice. These requirements include compliance with EU cGMP standards when manufacturing medicinal products and active pharmaceutical ingredients, including the manufacture of active pharmaceutical ingredients outside of the EU with the intention to import the active pharmaceutical ingredients into the EU.

The aforementioned EU rules are generally applicable in the European Economic Area, or EEA, which consists of the EU Member States, plus Norway, Liechtenstein and Iceland**.**

#### Brexit and the Regulatory Framework in the United Kingdom
On June 23, 2016, the electorate in the UK voted in favor of leaving the EU (commonly referred to as "Brexit"), and the UK formally left the EU on January 31, 2020. There was a transition period during which EU pharmaceutical laws continued to apply to the UK, which expired on December 31, 2020. However, the EU and the UK have concluded a trade and cooperation agreement, or TCA, which was provisionally applicable since January 1, 2021, and has been formally applicable since May 1, 2021. The TCA includes specific provisions concerning pharmaceuticals, which include the mutual recognition of GMP, inspections of manufacturing facilities for medicinal products and GMP documents issued but does not foresee wholesale mutual recognition of UK and EU pharmaceutical regulations. At present, Great Britain has implemented EU legislation on the marketing, promotion and sale of medicinal products through the Human Medicines Regulations 2012 (as amended) (under the Northern Ireland Protocol, the EU regulatory framework will continue to apply in Northern Ireland). The regulatory regime in Great Britain therefore currently aligns with EU regulations, however it is possible that these regimes will diverge in future now that Great Britain's regulatory system is independent from the EU and the TCA does not provide for mutual recognition of UK and EU pharmaceutical legislation.

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#### Pricing and Reimbursement
*United States* 

Sales of our products will depend, in part, on the extent to which our products, once approved, will be covered and reimbursed by third-party payors, such as government health programs, commercial insurance and managed healthcare organizations. These third-party payors are increasingly reducing reimbursements for medical products and services. The process for determining whether a third-party payor will provide coverage for a drug product, including a biologic, typically is separate from the process for setting the price of a drug product or for establishing the reimbursement rate that a payor will pay for the drug product once coverage is approved. Third-party payors are increasingly challenging the prices charged, examining the medical necessity, and reviewing the cost-effectiveness of medical products and services and imposing controls to manage costs. Third-party payors may limit coverage to specific drug products on an approved list, also known as a formulary, which might not include all of the approved drugs for a particular indication. As a result, the coverage determination process is often a time-consuming and costly process that will require us to provide scientific and clinical support for the use of our products to each payor separately, with no assurance that coverage and adequate reimbursement will be obtained.

In the United States and markets in other countries, patients generally rely on third-party payors to reimburse all, or part of the costs associated with their treatment. Adequate coverage and reimbursement from governmental healthcare programs, such as Medicare and Medicaid, and commercial payors is critical to new product acceptance. Our ability to successfully commercialize our product candidates will depend in part on the extent to which coverage and adequate reimbursement for these products and related treatments will be available from government health administration authorities, private health insurers and other organizations. Even if coverage is provided, the approved reimbursement amount may not be high enough to allow us to establish or maintain pricing sufficient to realize a sufficient return on our investment. Government authorities and third-party payors, such as private health insurers and health maintenance organizations, decide which medications they will pay for and establish reimbursement levels.

In order to secure coverage and reimbursement for any drug product candidate that might be approved for sale, we may need to conduct expensive pharmacoeconomic studies in order to demonstrate the medical necessity and cost-effectiveness of the drug product candidate, in addition to the costs required to obtain FDA or other comparable regulatory approvals. Whether or not we conduct such studies, our product candidates may not be considered medically necessary or cost-effective. A third-party payor's decision to provide coverage for a drug product does not imply that an adequate reimbursement rate will be approved. Further, one payor's determination to provide coverage for a product does not assure that other payors will also provide coverage, and adequate reimbursement, for the product. Third party reimbursement may not be sufficient to enable us to maintain price levels high enough to realize an appropriate return on our investment in product development.

The containment of healthcare costs has become a priority of federal and state governments, and the prices of drugs, including biologics, have been a focus in this effort. The U.S. government, state legislatures and foreign governments have shown significant interest in implementing cost-containment programs, including price controls, restrictions on reimbursement and requirements for substitution of generic products. Adoption of price controls and cost-containment measures, and adoption of more restrictive policies in jurisdictions with existing controls and measures, could further limit our net revenue and results. Net prices for drugs may be reduced by mandatory discounts or rebates required by government healthcare programs or private payors and by any future relaxation of laws that presently restrict imports of drugs from countries where they may be sold at lower prices than in the United States. Increasingly, third-party payors are requiring that drug companies provide them with predetermined discounts from list prices and are challenging the prices charged for medical products. We cannot be sure that reimbursement will be available for any product candidate that we commercialize and, if reimbursement is available, the level of reimbursement. In addition, many pharmaceutical manufacturers must calculate and report certain price reporting metrics to the government, such as average sales price, or ASP, and best price. Penalties may apply in some cases when such metrics are not submitted accurately and timely. Further, these prices for drugs may be reduced by mandatory discounts or rebates required by government healthcare programs. Decreases in third-party reimbursement for our drug product candidate or a decision by a third-party payor to not cover our drug product candidate could reduce physician usage of the drug product candidate and have a material adverse effect on our sales, results of operations and financial condition.

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For example, the ACA, enacted in March 2010, has had a significant impact on the health care industry. The ACA has expanded coverage for the uninsured while at the same time containing overall healthcare costs. With regard to pharmaceutical products, among other things, the ACA expanded and increased industry rebates for drugs covered under Medicaid programs and made changes to the coverage requirements under the Medicare Part D program.

In addition, other legislative changes have been proposed and adopted in the United States since the ACA was enacted. On August 2, 2011, the Budget Control Act of 2011 among other things, created measures for spending reductions by Congress. A Joint Select Committee on Deficit Reduction, tasked with recommending a targeted deficit reduction of at least $1.2 trillion for the years 2013 through 2021, was unable to reach required goals, thereby triggering the legislation's automatic reduction to several government programs. This includes aggregate reductions to Medicare payments to providers of up to 2% per fiscal year, started in April 2013 and will stay in effect through 2030 unless additional Congressional action is taken.

Pursuant to the Coronavirus Aid, Relief, and Economic Security Act, also known as the CARES Act, as well as subsequent legislation, these reductions were suspended from May 1, 2020, through March 31, 2022, due to the COVID-19 pandemic. Then, a 1% payment reduction was in effect beginning April 1, 2022, through June 30, 2022, and the 2% payment reduction resumed on July 1, 2022.

Since its enactment, there have been numerous judicial, administrative, executive, and legislative challenges to certain aspects of the ACA. On June 17, 2021, the U.S. Supreme Court dismissed the most recent judicial challenge to the ACA brought by several states without specifically ruling on the constitutionality of the ACA. Prior to the Supreme Court's decision, President Biden issued an Executive Order to initiate a special enrollment period from February 15, 2021, through August 15, 2021 for purposes of obtaining health insurance coverage through the ACA marketplace. The Executive Order also instructed certain governmental agencies to review and reconsider their existing policies and rules that limit access to healthcare, including among others, reexamining Medicaid demonstration projects and waiver programs that include work requirements, and policies that create unnecessary barriers to obtaining access to health insurance coverage through Medicaid or the ACA. It is unclear how other healthcare reform measures of the Biden administrations or other efforts, if any, to challenge repeal or replace the ACA, will impact our business.

Further, on May 30, 2018, the Right to Try Act, was signed into law. The law, among other things, provides a federal framework for certain patients to access certain investigational new drug products that have completed a Phase 1 clinical trial and that are undergoing investigation for FDA approval. Under certain circumstances, eligible patients can seek treatment without enrolling in clinical trials and without obtaining FDA permission under the FDA expanded access program. There is no obligation for a pharmaceutical manufacturer to make its drug products available to eligible patients as a result of the Right to Try Act.

In addition, there have been several changes to the 340B drug pricing program, which imposes ceilings on prices that drug manufacturers can charge for medications sold to certain health care facilities. On December 27, 2018, the District Court for the District of Columbia invalidated a reimbursement formula change under the 340B drug pricing program, and CMS subsequently altered the FYs 2019 and 2018 reimbursement formula on specified covered outpatient drugs ("SCODs"). The court ruled this change was not an "adjustment" which was within the Secretary's discretion to make but was instead a fundamental change in the reimbursement calculation. However, most recently, on July 31, 2020, the U.S. Court of Appeals for the District of Columbia Circuit overturned the district court's decision and found that the changes were within the Secretary's authority. On September 14, 2020, the plaintiffs-appellees filed a Petition for Rehearing En Banc (i.e., before the full court), but was denied on October 16, 2020. Plaintiffs-appellees filed a petition for a writ of certiorari at the Supreme Court on February 10, 2021. On Friday July 2, 2021, the Supreme Court granted the petition. It is unclear how these developments could affect covered hospitals who might purchase our future products and affect the rates we may charge such facilities for our approved products in the future, if any.

In August 2022, the IRA was signed into law. The IRA includes several provisions that will impact our business to varying degrees, including provisions that create a $2,000 out-of-pocket cap for Medicare Part D beneficiaries, impose new manufacturer financial liability on all drugs in Medicare Part D, allow the U.S. government to negotiate Medicare Part B and Part D pricing for certain high-cost drugs and biologics without generic or biosimilar competition, require companies to pay rebates to Medicare for drug prices that increase faster than inflation, and delay the rebate rule that would require pass through of pharmacy benefit manager rebates to beneficiaries.

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In addition, in some foreign countries, the proposed pricing for a drug must be approved before it may be lawfully marketed. The requirements governing drug pricing vary widely from country to country.

*European Union* 

In the EU, pricing and reimbursement for pharmaceutical products are not harmonized and fall within the exclusive competence of the national authorities, provided that basic transparency requirements (such as maximum timelines) defined at the European level are met as set forth in Directive 89/105/EEC relating to the transparency of measures regulating the prices of medicinal products for human use and their inclusion in the scope of national health insurance systems. A Member State may approve a specific price for a medicinal product, or it may instead adopt a system of direct or indirect controls on the profitability of the company placing the medicinal product on the market. For example, in France, effective access to the market assumes that our future products will be reimbursed by social security. The price of medications is negotiated with the Economic Committee for Health Products, or CEPS.

As a consequence, reimbursement mechanisms by public national healthcare systems, or private health insurers also vary from country to country. In public healthcare systems, reimbursement is determined by guidelines established by the legislator or the national competent authority. In general, inclusion of a product in reimbursement schemes is dependent upon proof of the product efficacy, medical need, and economic benefits of the product to patients and the healthcare system in general. Acceptance for reimbursement comes with cost, use and often volume restrictions, which again vary from country to country.

The pricing and reimbursement level for medicinal products will depend on the strength of the clinical data set and, as for most novel therapies, restrictions may apply. In most countries, national competent authorities ensure that the prices of registered medicinal products sold in their territory are not excessive. In making this judgment, they usually compare the proposed national price either to prices of existing treatments and/or to prices of the product at issue in other countries – so-called "international reference pricing" – also taking into account the type of treatment (preventive, curative or symptomatic), the degree of innovation, the therapeutic breakthrough, volume of sales, sales forecast, size of the target population and/or the improvement (including cost savings) over comparable treatments. Given the growing burden of medical treatments on national healthcare budgets, reimbursement and insurance coverage is an important determinant of the accessibility of medicines.

The various public and private plans, formulary restrictions, reimbursement policies, patient advocacy groups, and cost-sharing requirements may play a role in determining effective access to the market of our product candidates. The national competent authorities may also use a range of policies and other initiatives intended to influence pharmaceutical consumption. There can be no assurance that any country that has price controls or reimbursement limitations for pharmaceutical products will allow favorable reimbursement and pricing arrangements for any of our product candidates. Historically, products launched in the EU do not follow price structures of the United States and generally tend to be priced at a significantly lower level.

#### Other Healthcare Laws and Compliance Requirements
Our business operations in the United States and our arrangements with clinical investigators, healthcare providers, consultants, third-party payors and patients may expose us to broadly applicable federal and state fraud and abuse and other healthcare laws. These laws may impact, among other things, our research, proposed sales, marketing and education programs of our product candidates that obtain marketing approval. The laws that may affect our ability to operate include, among others:

• The federal Anti-Kickback Statute, which prohibits, among other things, persons and entities from knowingly and willfully soliciting, receiving, offering or paying remuneration (including any kickback, bribe or rebate), directly or indirectly, in cash or in kind, to induce or reward, or in return for, either the referral of an individual for, or the purchase, lease, order, or recommendation of, an item, good, facility or service reimbursable under a federal healthcare program, such as the Medicare and Medicaid programs. A person or entity does not need to have actual knowledge of the federal Anti-Kickback Statute or specific intent to violate it to have committed a violation. Violations are subject to civil and criminal fines and penalties for each violation, plus up to three times the remuneration involved, imprisonment, and exclusion from government healthcare programs. In addition, the government may assert that a claim including items or services resulting from a violation of the federal Anti-Kickback Statute constitutes a false or fraudulent claim for purposes of the federal False Claims Act or federal civil monetary penalties;

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• Federal civil and criminal false claims laws and civil monetary penalty laws, which impose penalties and provide for civil whistleblower or qui tam actions against individuals and entities for, among other things, knowingly presenting, or causing to be presented, claims for payment from Medicare, Medicaid, or other third-party payers that are false or fraudulent, or making a false statement or record material to payment of a false claim or avoiding, decreasing, or concealing an obligation to pay money to the federal government, including for example, providing inaccurate billing or coding information to customers or promoting a product off-label. Manufacturers can be held liable under the federal False Claims Act even when they do not submit claims directly to government payors if they are deemed to "cause" the submission of false or fraudulent claims. The federal False Claims Act also permits a private individual acting as a "whistleblower" to bring actions on behalf of the federal government alleging violations of the federal False Claims Act and to share in any monetary recovery;

• The federal Health Insurance Portability and Accountability Act of 1996, or HIPAA, which created federal criminal statutes that prohibit, among other things, a person from knowingly and willfully executing, or attempting to execute, a scheme to defraud any healthcare benefit program, or obtaining money or property of the health care benefit program through false pretenses, representations, or promises any of the money or property owned by, or under the custody or control of, any healthcare benefit program, regardless of the payor (e.g., public or private) and knowingly and willingly falsifying, concealing or covering up a material fact, making false statements or using or making any false, fictitious, or fraudulent document in connection with the delivery of or payment for healthcare benefits or services; similar to the federal Anti-Kickback Statute, a person or entity does not need to have actual knowledge of the statute or specific intent to violate it in order to have committed a violation.

• The federal Physician Payments Sunshine Act, enacted as part of the ACA, which requires applicable manufacturers of covered drugs, devices, biologics and medical supplies to track and annually report to CMS payments and other transfers of value provided to physicians and teaching hospitals and certain ownership and investment interest held by physicians or their immediate family members in applicable manufacturers and group purchasing organizations. HITECH also created new tiers of civil monetary penalties, amended HIPAA to make civil and criminal penalties directly applicable to business associates, and gave state attorneys general new authority to file civil actions for damages or injunctions in federal courts to enforce the federal HIPAA laws and seek attorneys' fees and costs associated with pursuing federal civil actions. In addition, there may be additional federal, state and non-U.S. laws which govern the privacy and security of health and other personal information in certain circumstances, many of which differ from each other in significant ways and may not have the same effect, thus complicating compliance efforts;

• HIPAA, as amended by the Health Information Technology and Clinical Health Act, or HITECH, and its implementing regulations, including the Final Omnibus Rule published in January 2013, which imposes certain requirements on covered entities and their business associates relating to the privacy, security and transmission of individually identifiable health information;

• The U.S. federal transparency requirements under the ACA, including the provision commonly referred to as the Physician Payments Sunshine Act, and its implementing regulations, which requires applicable manufacturers of drugs, devices, biologics and medical supplies for which payment is available under Medicare, Medicaid or the Children's Health Insurance Program to report annually to CMS, information related to payments or other transfers of value made to physicians (defined to include doctors, dentists, optometrists, podiatrists and chiropractors) and teaching hospitals, as well as ownership and investment interests held by the physicians described above and their immediate family members. Effective January 1, 2022, these reporting obligations extend to include transfers of value made to certain non-physician providers (physician assistants, nurse practitioners, clinical nurse specialists, certified registered nurse anesthetists and anesthesiologist assistants, and certified-nurse midwives);

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• federal government price reporting laws, which require us to calculate and report complex pricing metrics in an accurate and timely manner to government programs;

• federal consumer protection and unfair competition laws, which broadly regulate marketplace activities and activities that potentially harm consumers; and

• State law and foreign law equivalents of each of the above federal laws, such as state anti-kickback and false claims laws which may apply to items or services reimbursed by any third-party payor, including commercial insurers, state marketing and/or transparency laws applicable to manufacturers that may be broader in scope than the federal requirements, state laws that require biopharmaceutical companies to comply with the biopharmaceutical industry's voluntary compliance guidelines. Several states also impose other marketing restrictions or require pharmaceutical companies to make marketing or price disclosures to the state and require the registration of pharmaceutical sales representatives. State and foreign laws, including for example the European Union General Data Protection Regulation, which became effective May 2018 also govern the privacy and security of health information in some circumstances, many of which differ from each other in significant ways and often are not preempted by HIPAA, thus complicating compliance efforts. There are ambiguities as to what is required to comply with these state requirements and if we fail to comply with an applicable state law requirement, we could be subject to penalties. Finally, there are state and foreign laws governing the privacy and security of health information in certain circumstances, many of which differ from each other in significant ways and may not have the same effect as HIPAA, thus complicating compliance efforts.

The ACA broadened the reach of the federal fraud and abuse laws by, among other things, amending the intent requirement of the federal Anti-Kickback Statute and certain applicable federal criminal healthcare fraud statutes. Pursuant to the statutory amendment, a person or entity no longer needs to have actual knowledge of this statute or specific intent to violate it in order to have committed a violation. In addition, the ACA provides that the government may assert that a claim including items or services resulting from a violation of the federal Anti-Kickback Statute constitutes a false or fraudulent claim for purposes of the civil False Claims Act or the civil monetary penalties statute.

In the U.S., to help patients afford our approved product, we may utilize programs to assist them, including patient assistance programs and co-pay coupon programs for eligible patients. Government enforcement agencies have shown increased interest in pharmaceutical companies' product and patient assistance programs, including reimbursement support services, and a number of investigations into these programs have resulted in significant civil and criminal settlements. In addition, at least one insurer has directed its network pharmacies to no longer accept co-pay coupons for certain specialty drugs the insurer identified. Our co-pay coupon programs could become the target of similar insurer actions. In addition, in November 2013, the CMS issued guidance to the issuers of qualified health plans sold through the ACA's marketplaces encouraging such plans to reject patient cost-sharing support from third parties and indicating that the CMS intends to monitor the provision of such support and may take regulatory action to limit it in the future. The CMS subsequently issued a rule requiring individual market qualified health plans to accept third-party premium and cost-sharing payments from certain government-related entities. In September 2014, the OIG of the HHS issued a Special Advisory Bulletin warning manufacturers that they may be subject to sanctions under the federal anti-kickback statute and/or civil monetary penalty laws if they do not take appropriate steps to exclude Part D beneficiaries from using co-pay coupons. Accordingly, companies exclude these Part D beneficiaries from using co-pay coupons. It is possible that changes in insurer policies regarding co-pay coupons and/or the introduction and enactment of new legislation or regulatory action could restrict or otherwise negatively affect these patient support programs, which could result in fewer patients using affected products, and therefore could have a material adverse effect on our sales, business, and financial condition.

Third party patient assistance programs that receive financial support from companies have become the subject of enhanced government and regulatory scrutiny. The OIG has established guidelines that suggest that it is lawful for pharmaceutical manufacturers to make donations to charitable organizations who provide co-pay assistance to Medicare patients, provided that such organizations, among other things, are bona fide charities, are entirely independent of and not controlled by the manufacturer, provide aid to applicants on a first-come basis according to consistent financial criteria and do not link aid to use of a donor's product. However, donations to patient assistance programs have received some negative publicity and have been the subject of multiple government enforcement

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actions, related to allegations regarding their use to promote branded pharmaceutical products over other less costly alternatives. Specifically, in recent years, there have been multiple settlements resulting out of government claims challenging the legality of their patient assistance programs under a variety of federal and state laws. It is possible that we may make grants to independent charitable foundations that help financially needy patients with their premium, co-pay, and co-insurance obligations. If we choose to do so, and if we or our vendors or donation recipients are deemed to fail to comply with relevant laws, regulations or evolving government guidance in the operation of these programs, we could be subject to damages, fines, penalties, or other criminal, civil, or administrative sanctions or enforcement actions. We cannot ensure that our compliance controls, policies, and procedures will be sufficient to protect against acts of our employees, business partners, or vendors that may violate the laws or regulations of the jurisdictions in which we operate. Regardless of whether we have complied with the law, a government investigation could impact our business practices, harm our reputation, divert the attention of management, increase our expenses, and reduce the availability of foundation support for our patients who need assistance.

On December 2, 2020, the HHS published a regulation removing safe harbor protection for price reductions from pharmaceutical manufacturers to plan sponsors under Part D, either directly or through pharmacy benefit managers (PBMs), unless the price reduction is required by law. The rule also creates a new safe harbor for price reductions reflected at the point-of-sale, as well as a safe harbor for certain fixed fee arrangements between PBMs and manufacturers. Pursuant to court order, the removal and addition of the aforementioned safe harbors were delayed and recent legislation imposed a moratorium on implementation of the rule until January 1, 2026. The IRA delayed implementation of this rule to January 1, 2032.

Further, on December 31, 2020, CMS published a new rule, effective January 1, 2023, requiring manufacturers to ensure the full value of co-pay assistance is passed on to the patient or these dollars will count toward the Average Manufacturer Price and Best Price calculation of the drug. On May 21, 2021, PhRMA sued the HHS in the U.S. District Court for the District of Columbia, to stop the implementation of the rule claiming that the rule contradicts federal law surrounding Medicaid rebates. It is unclear how the outcome of this litigation will affect the rule. The IRA delays implementation of the rule. We cannot predict how the implementation of and any further changes to this rule will affect our business.

The scope and enforcement of each of these laws is uncertain and subject to rapid change in the current environment of healthcare reform, especially in light of the lack of applicable precedent and regulations. Federal and state enforcement bodies have recently increased their scrutiny of interactions between healthcare companies and healthcare providers, which has led to a number of investigations, prosecutions, convictions and settlements in the healthcare industry.

Efforts to ensure that our business arrangements with third parties will comply with applicable healthcare laws will involve substantial costs. It is possible that governmental authorities will conclude that our business practices may not comply with current or future statutes, regulations or case law involving applicable fraud and abuse or other healthcare laws. If our operations are found to be in violation of any of these laws or any other governmental regulations that may apply to us, we may be subject to significant administrative, civil, and/or criminal penalties, damages, fines, disgorgement, individual imprisonment, exclusion from government funded healthcare programs, such as Medicare and Medicaid, and the curtailment or restructuring of our operations. Further, defending against any such actions can be costly and time consuming, and may require significant financial and personnel resources. Therefore, even if we are successful in defending against any such actions that may be brought against us, our business may be impaired. If the physicians or other healthcare providers or entities with whom we expect to do business are found to be not in compliance with applicable laws, they also may be subject to administrative, civil, and/or criminal sanctions, including exclusions from government funded healthcare programs. If any of the above occur, our ability to operate our business and our results of operations could be adversely affected.

#### Legal Proceedings
From time to time, we may become involved in legal proceedings or be subject to claims arising in the ordinary course of our business. Regardless of the outcome, litigation can have an adverse impact on us because of defense and settlement costs, diversion of management resources and other factors.

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In December 2020, Horizon Discovery was acquired by PerkinElmer, Inc. (Horizon/PKI).

In 2021, Horizon/PKI informed us they believe we are in material breach of these agreements as a result of certain disclosures we have made in connection with our obligations as a publicly traded company in the United States and Belgium, although they have not formally delivered to us a notice of material breach or termination. We believe any such assertion of material breach would be without merit and we would expect to vigorously defend any such notice of material breach. Any dispute under these agreements would be subject to arbitration in The Hague under the International Chamber of Commerce Rules. We are currently in discussions with Horizon about possible amendments to these agreements in connection with which we would retain freedom to operate under the in-licensed patents.

Of note, we have filed patent applications which, if issued, would cover other aspects of the product candidates described above as well as products developed by third parties that deploy similar technology and targets. These patent applications encompass the downregulation of one or more of the targets covered under the Horizon/PKI agreements, the use of shRNA to downregulate such targets in immune cells and the combination of shRNAs with a chimeric antigen receptor in immune cells. We are also developing a second generation shRNA platform that does not incorporate any of the Horizon Discovery/Perkin Elmer, Inc. technology described above.

Our discontinued allogeneic CAR T product candidate, CYAD-101, does not incorporate any of the Horizon Discovery/Perkin Elmer, Inc. technology described above.

C. Organizational Structure.

We and our subsidiaries, or the Group, is made of the following entities as of December 31, 2022. The following diagram illustrates our corporate structure.

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| | | | | | |
|:---|:---|:---|:---|:---|:---|
| **Name** | **Country of<br>Incorporation and<br>Place of Business** | **Nature of Business** | **Proportion of<br>ordinary**<br>**shares directly<br>held by parent (%)** | **Proportion of<br>ordinary shares<br>held by us (%)** | **Proportion of<br>ordinary shares<br>held by non-**<br>**controlling<br>interests (%)** |
|  Celyad Oncology SA | BE | Biopharma | Parent company |  |  |
|  Celyad Inc | US | Biopharma | 100% | 100% | 0% |
|  CorQuest Medical Inc | US | Medical Device | 100% | 100% | 0% |
|  Biological Manufacturing Services SA | BE | Manufacturing | 100% | 100% | 0% |

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See "Item 4.A.—History and Development of the Company."

D. Property, Plants and Equipment.

Until December 31, 2022, we rented a 2,284 square meter office space from the Axis Parc developer located at the Axis Parc in Mont-Saint-Guibert pursuant to a lease agreement dated October 15, 2015, as amended from time to time, which expired on June 30, 2025. In December 2022, we took the decision to terminate and transfer our rent agreement to Cellistic and to move our offices within 2023, to a new office space more aligned with our new strategy. As of December 31, 2022, we terminated the rent agreement of the Axis Parc developer located at the Axis Parc in Mont-Saint-Guibert, Belgium. As of January 1, 2023, we contracted a short term lease with Cellistic for 600 square feet of office space in Axis Parc in Mont-Saint-Guibert, Belgium, during the time needed for the set-up of our new offices.

Until September 30, 2022, we also rented a 1,120 square meter office and laboratory space from the Axis Parc developer pursuant to a lease agreement dated June 30, 2020, as amended from time to time, which expires on June 30, 2029. In September 2022, our Manufacturing Business Unit based in this office and laboratory space was sold to Cellistic. Consequent to this transaction, we terminated the rent agreement of the Axis Parc developer.

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In September 2016, we entered into a six-year lease agreement for our U.S. corporate offices (555 square meter office space) located in Boston, Massachusetts. Since February 2018, this office space is subleased to a third party through the end of the six-year lease agreement. The six-year lease and sublease agreements have ended in September 2022.

We have committed to maintain our headquarters and registered office in the Walloon Region of Belgium and all of our existing activities will continue to be performed in the Walloon Region.

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| | |
|:---|:---|
| **ITEM 4A.** | **UNRESOLVED STAFF COMMENTS.**  |

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Not applicable.

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|:---|:---|
| **ITEM 5.** | **OPERATING AND FINANCIAL REVIEW AND PROSPECTS**  |

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*Information pertaining to fiscal year 2020 was included in our Annual Report on Form 20-F for the year-ended December 31, 2021, on pages 88-104, under Item 5, "Operating and Financial Review and Prospects," which was filed with the SEC on March 24, 2022.* 

We are a biotechnology company focused on the discovery and development of innovative technologies for chimeric antigen receptor T-cell (CAR T) therapies. Our goal is to discover and develop proprietary technology platforms to support the development of next-generation CAR T-cell therapy candidates. The Company is focusing on opportunities to fully harness the true potential of its proprietary technology platforms and intellectual property.

Over the past decades, immunotherapy has become an important treatment option for cancer indications. Within the field of immuno-oncology, chimeric antigen receptor (CAR) T-cell therapy is emerging as a realistic treatment paradigm for patients with advanced disease.

Our differentiated strategy includes the development of technologies and platforms to tackle the current major limitations of CAR T-cell therapies.

Our non-gene edited technologies target the TCR specifically without extensive genetic manipulation. Through the co-expression of our non-gene edited technologies with a specific CAR of interest, we can design cell therapy candidates intended to inhibit the function of the TCR while allowing the T-cells to target the cancer. We believe this unique strategy offers a streamlined approach in advancing the allogeneic CAR T-cell landscape.

Central to our pipeline is a cutting-edge all-in-one vector approach where we focus on using a single vector to generate CAR T-cells to simplify the design and development of our cell therapy candidates. The all-in-one vector approach encodes multiple components of the CAR construct simultaneously, including the CAR, shRNA targeting genes involved in alloreactivity, persistence, anti-tumor activity or ability to evade complex or immunosuppressive tumor microenvironments, cell selection marker to assist with the enrichment of the manufactured cells and potential therapeutic add-ons such as cytokines. This single transduction, plug and play approach to CAR T-cell development has the potential to streamline process development and manufacturing while broadening the potential applicability of our candidates.

Since our acquisition of OnCyte LLC, or OnCyte, a wholly-owned subsidiary of Celdara Medical, LLC, a privately-held U.S. biotechnology company, we have devoted the majority of our financial resources to research and development of CAR T-cell therapy product candidates. Since October 2022, we have implemented a strategic shift from an organization focused on clinical development to one prioritizing R&D discovery and the monetization of its intellectual property (IP) portfolio through partnerships, collaborations and license agreements. Our current efforts are focused on discovery research, protecting and monetizing our intellectual property and general and administrative support for these operations. We currently do not have any products approved for sale, no firm sublicence contract nor collaboration contract and have not generated any revenues from immunotherapy product sales or from the monetization of our IP.

As of December 31, 2022, we have been funded through the following transactions:

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• Proceeds of €42.0 million from private financing rounds;

• Proceeds of €26.5 million from an initial public offering of our ordinary shares on Euronext Brussels and Euronext Paris in July 2013, or the Euronext IPO;

• Proceeds of €25.0 million from a private financing by Medisun International Limited, or Medisun, in June 2014;

• Proceeds of €31.7 million from a private placement in March 2015;

• Proceeds of €88.0 million from a global offering of 1,460,000 ordinary shares, consisting of an underwritten public offering of 1,168,000 ADSs and a concurrent European private placement of 292,000 ordinary shares, in June 2015;

• Proceeds of €46.1 million from a global offering of 2,070,000 ordinary shares, consisting of an underwritten public offering of 568,500 ordinary shares in the form of ADSs and 1,501,500 ordinary shares, in May 2018;

• Proceeds of €18.2 million from a global offering of 2,000,000 ordinary shares, consisting of an underwritten public offering of 1,675,000 ordinary shares in the form of ADSs and 325,000 ordinary shares, in September 2019;

• Proceeds of €9.2 million from issuance of 1,962,812 ADS to LPC from January 8, 2021, until the date of this Annual Report. On January 8, 2021, the Company has entered into a committed equity purchase agreement ("Purchase Agreement") for up to $40.0 million with Lincoln Park Capital Fund, LLC ("LPC"), a Chicago-based institutional investor. Over the 24-month term of the Purchase Agreement, the Company will have the right to direct LPC to purchase up to an aggregate amount of $40.0 million American Depositary Shares ("ADSs"), each of which represents one ordinary share of the Company;

• Proceeds of €0.9 million from issuance of a total of 188,800 new shares by the Company and subscribed by Jefferies under the ATM in May 2021 and June 2021;

• Proceeds of €28.9 million from issuance of 6,500,000 new shares were issued by decision of the board of directors and subscribed for by CFIP CLYD LLC in the framework of a private placement in December 2021; and

• Proceeds of €37.1 million from recoverable cash advances, or RCAs, granted by Walloon Region government, and €6.4 million from other grants granted by Walloon Region, Federal Belgian Institute for Health Insurance Inami and Federal Government through the R&D tax credit. The RCAs are a non-dilutive financing source.

We have incurred net losses in each year since our inception. Substantially all of our net losses have resulted from costs incurred in connection with our research and development programs and from general and administration expenses associated with our operations. For the years ended December 31, 2022, 2021 and 2020, we incurred a loss for the year of €40.9 million, €26.5 million and, €17.2 million, respectively. As of December 31, 2022, we had an accumulated deficit of €349.9 million. We expect to incur losses for the foreseeable future relating to our research and development expenditures to develop our technologies. We anticipate that our expenses will increase substantially in connection with our ongoing activities if and as we:

• Continue our research, preclinical development of our product candidates;

• Initiate additional preclinical studies of existing product candidates or new product candidates;

• Change or add additional manufacturers or suppliers;

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• Make milestone or other payments under any in-license agreements; and

• Maintain, protect and expand our intellectual property portfolio.

We do not expect to generate material revenue unless and until the Group concludes partnerships with outside parties around the licensing of the patents around allogeneic CAR T-cell therapies and NKG2D-based therapies and other preclinical product candidates and on our technology platforms.

We do not expect to generate material revenue from partnerships with outside parties around the licensing of our patents, which is subject to significant uncertainty. Accordingly, we anticipate that we will need to raise additional capital prior to partner with outside parties around the licensing of our patents. Until we can generate a sufficient amount of revenue from our IP assets, if ever, we expect to finance our operating activities through a combination of equity offerings, debt financings, government, including RCAs and subsidies, or other third-party financings and collaborations. Additional capital may not be available on reasonable terms, if at all. If we are unable to raise additional capital in sufficient amounts or on terms acceptable to us, we may have to significantly delay, scale back or discontinue the development of one or more of our preclinical activities and IP assets. Failure to receive additional funding could cause us to cease operations, in part or in full.

Our financial statements for 2020, 2021 and 2022 have been prepared in accordance with International Financial Reporting Standards ("IFRS"), as issued by the International Accounting Standards Board ("IASB").

#### Financial Operations Overview
A. Operating Results

Our operating income consists of revenues and other income.

#### Revenues
The Company's license and collaboration agreements have generated no revenue in 2022 and in 2021.

#### Cost of sales
For the years 2022 and 2021, no costs of sales related to our programs have been recorded.

#### Research and Development expenses
For the periods presented in this report, research and development expenses included all of our operating expenses, except the general and administrative expenses. It included all the costs related to our operations in the following departments; research and development, clinical, manufacturing, regulatory, quality and intellectual property.

We utilize our research and development staff and infrastructure resources across projects in our programs and many of our costs historically have not been specifically attributable to a single project. In addition, our research and development expense may vary substantially from period to period based on the timing and scope of our research and development activities and the timing of our clinical trials.

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Research and development activities are central to our business. We expect that our other research and development expenses will decrease in the future mostly with the update of our strategy moving from clinical programs activities to preclinical and IP monetization activities. The expected decrease in research and development expenditures will mostly relate to lower personnel costs, less outsourcing costs and no more clinical studies related costs.

Salaries represented the biggest cost by nature within our operations over the last three years. Our strategy is to internalize all operations when they become material or critical to our operations. We subcontract all one-time projects and tasks that cannot be taken in-house for quality or regulatory purposes. Other important costs of our operations are our preclinical studies and IP filing and maintenance fees.

The costs associated with preclinical studies are laboratory supplies and the costs of our outsourced research and development studies and services.

The costs associated with clinical studies were comprised of the preparation, the conduct and the supervision of our clinical trials. We expect that these expenses will decrease in the near future given our decision to discontinue our clinical programs. We cannot determine with certainty the duration and completion costs of the closing of our current clinical trials, nor can we determine as well as for IP monetization or if, when, or to what extent we will generate revenue from the sublicensing and sale of any of our current and future IP licenses.

We may never succeed in achieving sublicensing of our IP portfolio or preclinical outcomes. We cannot reasonably estimate the time and costs necessary to complete the development of our sublicensing models and preclinical assets or the period, if any, in which we will generate revenue. The duration, costs and timing of sublicensing our IP will depend on a variety of factors, including:

• The expense of filing, prosecuting, defending and enforcing patent claims and other intellectual property rights;

• Third parties' clinical trials of product candidates that sublicense our IP;

• The terms and timing of regulatory approvals of third parties' product candidates that license our IP;

• The ability of third parties to market, commercialize and achieve market acceptance of third parties' product candidates that license our IP; and

• The number, the design and the size of the clinical trials required by the regulatory authorities to seek marketing approval.

A change in the outcome of any of these variables with respect to the development of our sublicence models that we are developing could mean a significant change in the costs and timing associated with the development of such models.

Product candidates in later stages of clinical development generally have higher development costs than those in earlier stages of clinical development, primarily due to the increased size and duration of later-stage clinical trials.

We have not received regulatory approval from the FDA, EMA or any other regulatory authority to market any of our product candidates for which we discontinued the clinical programs.

In September 2022, Celyad Oncology's Manufacturing Business Unit (including the existing facility and all related personnel), in Mont-Saint-Guibert, Belgium, was sold to Cellistic for a total consideration of €6.0 million. For the periods presented in this Annual Report, the manufacturing expenses included the costs to manufacture our product candidates, combined with the costs associated with the process of developing such product candidates, including the scale-up and the automation of such processes. These costs were mainly comprised of the production of raw material and supplies, maintenance and calibration of equipment and the rental of Good Manufacturing Practices laboratory facilities. Raw materials were the main component of the cost of production of product candidates.

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As a result of the sale of our Manufacturing Business Unit, we terminated the lease of our production facility from a real estate company that was contracted through our wholly owned subsidiary, Biological Manufacturing Services SA.

Manufacturing expenses were mostly driven by the number and the size of clinical trials that we were conducting on our drug product candidates. We expect these expenses to decrease significantly in the near future as our clinical trials have been discontinued and our Manufacturing Business Unit has been sold.

#### General and administrative expenses
Our general and administrative expenses consist primarily of salaries, fees and other share-based compensation costs for personnel in executive, finance and accounting, people, communication and legal functions. It also includes costs related to professional fees for auditors and lawyers, consulting fees and insurances not related to research and development operations, and fees related to functions that are outsourced by us such as information technology, or IT. Our general and administrative expenses are expected to decrease in the near future due to our reorganization aligned with the needs of our new strategy.

#### Change in fair value of the contingent consideration and other financial liabilities
For the periods presented in this Annual Report, our change in fair value of the contingent consideration and other financial liabilities mainly refer to non-cash expenses relating to liability remeasurement required by IFRS.

#### Impairment of Oncology intangible assets
For the periods presented in this Annual Report, our impairment of oncology intangible assets mainly refers to the assessment made at each reporting date to estimate whether there is an indication that an asset may be impaired, unless there are indications of impairment at other points throughout the period.

#### Other income
For the periods presented in this Annual Report, our other income is primarily generated from:

(i) Recoverable cash advances ("RCAs");

(ii) Other governments grants;

(iii) R&D tax credits; or

(iv) The gain on sale of our Manufacturing Business Unit activities.

*Recoverable Cash Advances* 

RCAs support specific development programs and are typically granted by regional governmental entities, and in our case, the Walloon Region. All RCA contracts, in essence, consist of three phases, i.e., the "research phase", the "decision phase" and the "exploitation phase". During the research phase, we receive funds from the Walloon Region based on statements of expenses. In accordance with IAS 20.10A and IFRS Interpretations Committee's, or IC's, conclusion that contingently repayable cash received from a government to finance a research and development project is a financial liability under IAS 32, 'Financial instruments; Presentation', the RCAs are initially recognized as a financial liability at fair value, determined as per IFRS 9. The benefit (RCA grant component) consisting in the difference between the cash received (RCA proceeds) and the above-mentioned financial liability's fair value (RCA liability component) is treated as a government grant in accordance with IAS 20.

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The RCA grant component is recognized in profit or loss on a systematic basis over the periods in which the entity recognizes the underlying research and development expenses subsidized by the RCA. Subsequent measurement of the RCAs liability component (RCA financial liability) is performed at amortized cost using the cumulative catch-up approach, under which the carrying amount of the liability is adjusted to the present value of the future estimated cash flows, discounted at the liability's original effective interest rate. The resulting adjustment is recognized within profit or loss.

At the end of the research phase, we should within a period of six months decide whether or not to exploit the results of the research phase (decision phase). The exploitation phase may have a duration of up to 10 years. In the event we decide to exploit the results under an RCA, the relevant RCA becomes contingently refundable, and the fair value of the RCA liability adjusted accordingly, if required.

When we do not exploit (or cease to exploit) the results under an RCA, we have to notify the Walloon Region of this decision. This decision is our sole responsibility. The related liability is then discharged by the transfer of such results to the Walloon Region. Also, when we decide to renounce to its rights to patents which may result from the research, title to such patents will be transferred to the Walloon Region. In that case, the RCA liability is extinguished.

Since inception through December 31, 2022, we have received subsidy RCAs totaling €37.1 million. In 2023 and beyond, the Group will have to make exploitation decisions on the remaining RCAs (agreements numbered 8212, 8436 and 8516).

*Other Government Grants* 

Since inception, we have also received other types of grants from European Commission, Federal Belgian Institute for Health Insurance Inami and Walloon Region authorities and we expect to continue to apply for such grants (EU framework programs for research and development, investment subsidies, sales-promotion subsidies, etc.). These grants are used to partially finance early stage projects such as fundamental research, applied research and prototype design.

As of the date of this Annual Report, none of the grants we have received are subject to any conditions. As per our agreements with these governmental authorities, grants are paid upon our submission of a statement of expenses. We incur project expenses first and ask for partial reimbursement according to the terms of the agreements.

The government grants are recognized in profit or loss on a systematic basis over the periods in which we recognize as expenses the related costs that the grants are intended to compensate.

Since inception through December 31, 2022, we have received government grants totaling €5.0 million.

*R&D tax credit* 

Since financial year 2013, we have applied for R&D tax credit, a tax incentive measure for European SME's set-up by the Belgian federal government. When incurring R&D spend, a Company may either i) get a reduction of its taxable income (at current income tax rate applicable); or ii) if no sufficient taxable income is available, apply for the refund of the unutilized tax credits, calculated on the R&D expenses amount for the year. Such settlement occurs at the earliest 5 financial years after the tax credit application filed by a Company.

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Collection of the research and development tax credits since 2021 is totaling €1.4 million.

*Gain on sale of our Manufacturing Business Unit activities*

Gain on sale of CTMU activities results from the terms of the asset purchase agreement signed in September 2022 between Celyad Oncology and Cellistic under which Cellistic agreed to acquire Celyad Oncology's Manufacturing Business Unit for a total consideration of €6.0 million. The book value of assets sold to Cellistic was €0.6 million and allocated goodwill totaled €0.2 million.

#### Other expenses
For the periods presented in this Annual Report, our other expenses mainly refer to:

i. Non-cash expenses relating to liability remeasurement required by IFRS on the amortized cost remeasurement of the recoverable cash advances liability;

ii. Loss on disposals of Property, plant & equipment and intangible assets; or

iii. Amendment fees on license agreements.

#### Finance income
Finance income relates to interest income earned on bank accounts and from currency exchange rate differences. Our cash and cash equivalents have been deposited primarily in savings and deposit accounts with original maturities of three months or less. Savings and deposit accounts generate a modest amount of interest income. Given the level of market interest rates for corporate deposits of short-term maturities, the Group has not invested in short-term deposits over the years 2022 and 2021.

#### Finance expenses
Finance expenses relate to interest payable on bank or governmental loans (RCAs), finance leases and operating leases under IFRS 16, and overdrafts, as well as currency exchange rate differences.

#### Recently Issued Accounting Standards
For information regarding recently issued accounting standards, please see "Note 2— General information and statement of compliance" in our consolidated financial statements appended to this Annual Report.

#### Consolidated Financial Data
The following is a summary of our consolidated financial data.

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#### Comparisons for the Years Ended December 31, 2022 and 2021
*Revenues* 

Our license and collaboration agreements have generated no revenue in 2022 and 2021.

*Cost of sales* 

No operations qualify for such a presentation for the year ended December 31, 2022 and comparative period.

*Research and development expenses* 

---

| | | |
|:---|:---|:---|
| (€'000) | **For the year ended December 31,** | **For the year ended December 31,** |
|  | **2022** | **2021** |
|  Employee expenses | 9 062 | 9 475 |
|  Clinical study costs | 4 280 | 4 000 |
|  Preclinical study costs | 1 233 | 2 473 |
|  Depreciation | 1 231 | 1 276 |
|  IP filing and maintenance fees | 831 | 353 |
|  Rent and utilities | 610 | 670 |
|  Share-based payments | 425 | 644 |
|  Process development and scale-up | 396 | 770 |
|  Consulting fees | 320 | 568 |
|  Travel & Living | 126 | 85 |
|  Others | 415 | 459 |
|  **Total R&D expenses** | **18 928** | **20 773** |

---

The Research and Development expenses include pre-clinical, manufacturing, clinical, quality, intellectual property and regulatory expenses and other research and development expenses, which are aggregated and presented as a single line in the Company's consolidated financial statements.

Bottom-line, the R&D expenses show a year-over-year decrease of €1.8 million. The decrease in the Company's R&D expenses is primarily driven by:

• The decrease of employee expenses mainly related to movement of employees through the year ended December 31, 2022 to support the Group's reorganization around preclinical and clinical programs;

• The increase on clinical study costs mainly due to the new provision for onerous contracts for a total amount of €2.2 million in order to cover the contractual obligations after the Group's decision to discontinue the development of its remaining clinical programs in December 2022;

• The decrease of preclinical activities after the Group's decision to adopt and implement over the last few months of the year 2022 the new business strategy to focus on discovery research in areas of expertise where it can leverage the differentiated nature of its platforms;

• The increase on IP filing and maintenance fees in line with the new business strategy which has been adopted and implemented over the last few months of the year 2022 to focus on maximizing the Group's intellectual property (IP) portfolio;

• The decrease of the expenses associated with the share-based payments (non-cash expenses) related to the warrants plan offered to the employees, managers and directors, mainly related to the decrease in the fair market value of stock options issued in 2022; and

• The decrease of process development costs after the Group's decision to adopt and implement over the last few months of the year 2022 the new business strategy to focus on discovery research and discontinue the development of clinical programs.

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*General and administrative expenses* 

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| | | |
|:---|:---|:---|
| (€'000) | **For the year ended December 31,** | **For the year ended December 31,** |
|  | **2022** | **2021** |
|  Employee expenses | 3 801 | 3 575 |
|  Consulting fees | 2 870 | 2 254 |
|  Insurances | 1 967 | 1 642 |
|  Share-based payments | 1 199 | 1 529 |
|  Communication & Marketing | 239 | 434 |
|  Depreciation | 209 | 243 |
|  Travel & Living | 115 | 31 |
|  Rent | 109 | 50 |
|  Post-employment benefits | (55) | (7) |
|  Other | 92 | 157 |
|  **Total General and administration** | **10 546** | **9 908** |

---

General and Administrative expenses were €10.5 million in 2022 as compared to €9.9 million in 2021, an increase of €0.6 million. This increase primarily relates to the increase in insurances costs (D&O insurance principally) and consulting fees associated with legal and capital raise opportunities have been partially compensated by the decrease of expenses associated with share-based payments (non-cash expenses) related to the warrants plan offered to the employees, managers and directors, mainly related to the decrease in the fair market value of stock options issued in 2022.

*Change in fair value of contingent consideration and impairment of Oncology intangible assets* 

---

| | | |
|:---|:---|:---|
| **(€'000)** | For the year ended December 31, | For the year ended December 31, |
|  | **2022** | **2021** |
|  Change in fair value of contingent consideration | 14 679 | 847 |
|  **Total Change in fair value of contingent consideration** | **14 679** | **847** |

---

---

| | | |
|:---|:---|:---|
| **(€'000)** | For the year ended December 31, | For the year ended December 31, |
|  | **2022** | **2021** |
|  Impairment of Oncology intangible assets | (35 084) |  |
|  **Total Impairment of Oncology intangible assets** | **(35 084)** |  |

---

The fair value adjustment (€14.7 million) relating to the contingent consideration and other financial liabilities for the year ended December 31, 2022, is mainly driven by the full reversal of the liability. This liability is a result of business combination accounting (IFRS3) which requires the liability to be recorded unless the possibility of any outflow is remote. Due to the early stage of the implementation of the Celyad 2.0 strategy and the fact no firm sublicence contract nor collaboration contract was concluded as of December 31, 2022, Management had to recognize that significant uncertainty exists on the timing and amount of the new strategy outcomes and therefore concluded that, as of December 31, 2022, the possibility of any cash flow is remote regarding accounting standards definition. Management, to comply with the accounting standards, had to conclude on the full reversal of the contingent consideration and other financial liabilities associated to the potential future payments due to Celdara Medical, LLC and Dartmouth College associated to the Group's immuno-oncology platform at December 31, 2022, along with impairment of €35.1 million of related intangible assets

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This accounting conclusion, which reflects a picture of the situation at December 31, 2022, doesn't affect the Management's commitment to continue the exploitation of these IPs in its new Celyad 2.0 strategy. As soon as a future event (such as a firm sublicense or collaboration contract) will increase the probability of revenue, Management will estimate the reversal of the impairment which will be limited so that the carrying amount of the asset does not exceed its recoverable amount along with the remeasurement of the related contingent liability.

*Other income and expenses* 

<u>Other income</u> 

---

| | | |
|:---|:---|:---|
| **(€'000)** | For the year ended December 31, | For the year ended December 31, |
|  | **2022** | **2021** |
|  Grant income (RCAs) | 1 137 | 2 731 |
|  Grant income (Other) | 910 | 1 448 |
|  Remeasurement of RCAs | 1 447 |  |
|  R&D tax credit | 462 | 687 |
|  Gain on sale of CTMU activities | 5 187 |  |
|  Remeasurement of Leases | 169 |  |
|  Other | 48 | 43 |
|  **Total Other Income** | **9 360** | **4 909** |

---

Our other income is mainly associated with grants received from the Walloon Region mainly in the form of recoverable cash advances (RCAs) and R&D tax credit income:

• Grant income (RCAs): additional grant income has been recognized in 2022 on grants in the form of recoverable cash advances (RCAs) for contracts numbered 8212, 8436 and 1910028. In accordance with IFRS standards, the Company has earned grants for the period amounting to €1.6 million, out of which €0.5 million is accounted for as a financial liability and the remaining €1.1 million as a grant income. The decrease compared to December 31, 2021, is mainly associated with the decrease on additional grant income recognized on these conventions due to advancement of the subsidized programs;

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• The remeasurement income on the recoverable cash advances (RCAs) of €1.4 million for the year 2022 is mainly related to the Group decision to discontinue its remaining clinical programs, while the remeasurement on the recoverable cash advances (RCAs) was an expense for the year ended December 31, 2021;

• Grant income (Others): additional grant income has been recognized in 2022 on grants received from the regional government (contract numbered 8516), not referring to RCAs and not subject to reimbursement. The decrease compared to December 31, 2021 is mainly due to grant income recognized on grants received from the Federal Belgian Institute for Health Insurance Inami (€0.3 million) for which no revenue has been recognized in 2022 and from the regional government (contracts numbered 8066 and 8516 for €1.1 million) as the convention 8066 has been closed in 2021.

• R&D tax credit: the current year income decreased compared to December 31, 2021 due to lower eligible expenses on clinical activities and prioritization of discovery research in areas of expertise where it can leverage the differentiated nature of the Group's platforms;

• Gain on sale of CTMU activities results from the terms of the asset purchase agreement between Celyad Oncology and Cellistic under which Cellistic agreed to acquire Celyad Oncology's Manufacturing Business Unit for a total consideration of €6.0 million. The book value of assets sold to Cellistic was €0.6 million and allocated goodwill totaled €0.2 million; and

• Remeasurement of leases: results from the difference between the decrease in the lease liability and the decrease in the right-of-use asset both primarily driven by the termination of leases associated to CTMU facilities and the termination of the current lease associated to the corporate offices before their relocation in 2023.

<u>Other expenses</u> 

---

| | | |
|:---|:---|:---|
| **(€'000)** | For the year ended December 31, | For the year ended December 31, |
|  | **2022** | **2021** |
|  Clinical Development milestone payment |  |  |
|  Remeasurement of RCAs |  | 328 |
|  Loss on disposals of Property, plant & equipment | 132 | 1 |
|  Loss on disposals of Intangible assets | 58 |  |
|  Amendment fees on license agreement |  | 1 104 |
|  Other | 149 | 33 |
|  **Total Other Expenses** | **339** | **1 466** |

---

The decrease of the Company's other expenses is mainly related to the amendment fees on license agreement with Dartmouth for €1.1 million in 2021, while there has been no such amendment in 2022.

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*Operating loss* 

For the year ended December 31, 2022, the loss from operations amounted to €40.9 million versus €26.4 million in 2021 for the reasons stated above.

*Financial income and financial expenses* 

---

| | | |
|:---|:---|:---|
| **(€'000)** | **For the year ended December 31,** | **For the year ended December 31,** |
|  | **2022** | **2021** |
|  Interest finance leases | 150 | 217 |
|  Interest on overdrafts and other finance costs | 33 | 21 |
|  Interest on RCAs | 14 | 17 |
|  **Finance expenses** | **198** | **255** |
|  Finance income on the net investment in lease | 11 | 26 |
|  Interest income bank account | 1 | 1 |
|  Foreign Exchange differences | 173 | 5 |
|  Other financial income |  | 112 |
|  **Finance income** | **185** | **144** |
|  **Net Financial Result** | **(13)** | **(111)** |

---

Financial results refer mainly to interest on finance leases compensated by net gain on foreign exchange rate difference due to USD revaluation.

*Income taxes* 

As we incurred losses in all the relevant periods, we had no taxable income and therefore incurred no significant corporate taxes.

*Loss for the year* 

As a result of the foregoing, the net loss for the financial year 2022 amounts to €40.9 million, compared to a net loss of €26.5 million for the prior year for the reasons stated above.

B. Liquidity and Capital Resources

We have financed our operations since inception through several private placements of equity securities, several contributions in kind, an initial public offering on Euronext Brussels and Paris, an initial U.S. public offering on Nasdaq, follow-on offerings on Euronext and Nasdaq, and non-dilutive governmental support.

Through December 31, 2022, the total gross proceeds of the placement of our securities amounted to €338.3 million and total non-dilutive funding amounted to €43.5 million. For information on our use of and policies regarding financial instruments, please see Note 3 and Note 23 included in our consolidated financial statements appended to this Annual Report.

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The table hereunder summarizes our sources and uses of cash for the years ended December 31, 2022, 2021, and 2020.

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| | | | |
|:---|:---|:---|:---|
|  | **For the years ended December 31,** | **For the years ended December 31,** | **For the years ended December 31,** |
| **(€'000)** | **2022** | **2021** | **2020** |
|  Cash used in operating activities | (28 010) | (26 643) | (27 665) |
|  Cash from/(used in) investing activities | 7 202 | (126) | 157 |
|  Cash flows from financing activities | 3 241 | 39 521 | 5 396 |
|  **Net increase/(decrease) in cash and cash equivalents** | **(17 567)** | **12 752** | **(22 112)** |

---

*Comparison between 2022 and 2021* 

The cash outflow resulting from operating activities amounted to €28.0 million for the year ended December 31, 2022, which is in line with the €26.6 million for the year ended December 31, 2021.

The increase in cash inflow from investing activities is primarily due to:

• Proceeds from the sale of Manufacturing Business Unit to Cellistic for a gross amount of €6.0 million; and

• Proceeds from the sales of short-term investments associated to the sales of Mesoblast shares obtained on January 17, 2022, after the Group entered into an amendment with Mesoblast to convert the license into non-exclusive whereby consideration of $1,5 million was agreed to be paid by Mesoblast in Mesoblast ordinary shares.

The decrease in cash inflow from financing activities is primarily due to the decrease in the proceeds from capital raise as no capital increase occurred in 2022 while the proceeds from capital raise reached an amount of €36.6 million in 2021.

#### Cash and Funding Sources<sup>1</sup>
Over the last three years, we obtained new financing mostly through the issuance of our shares. A summary of our funding activities is as follows:

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| | | | | |
|:---|:---|:---|:---|:---|
| **(€'000)** | **Total** | **Equity capital** | **Finance leases** | **Loans** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 2020 |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 2021 | 36 568 | 36 568 |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 2022 |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Total financing** | **36 568** | **36 568** |  |  |

---

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<sup>1</sup> The uncertainly raised by the COVID-19 pandemic and war in Ukraine not impacting our corporate cash flow, capital resources and liquidity. For additional information on COVID-19 pandemic and war in Ukraine updates, refer to note 2.

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We refer to "Note 23—Financial instruments" included in our consolidated financial statements appended to this Annual Report for information related to the maturity profile of our leases and loans.

On January 8, 2021, the Company has entered into a committed equity purchase agreement ("Purchase Agreement") for up to $40.0 million with Lincoln Park Capital Fund, LLC ("LPC"), a Chicago-based institutional investor. Over the 24-month term of the Purchase Agreement, the Company will have the right to direct LPC to purchase up to an aggregate amount of $40.0 million American Depositary Shares ("ADSs"), each of which represents one ordinary share of the Company. From January 8, 2021, until December 31, 2021, a total of 1,962,812 new shares have been issued by the Company and subscribed by LPC for a cash proceed of €9.2 million, before deducting underwriting commissions and offering expenses. As of December 31, 2021, there is a remaining access to the equity purchase agreement established with LPC for an amount of $28.0 million.

On May 21, 2021 and June 14, 2021, a total of 188,800 new shares have been issued by the Company and subscribed by Jefferies under the ATM for a cash proceed of €0.9 million, before deducting underwriting commissions and offering expenses.

On December 8, 2021, 6,500,000 new shares were issued by decision of the board of directors and subscribed for by CFIP CLYD LLC in the framework of a private placement for a global cash proceed of €28.9 million ($32.5 million), before deducting underwriting commissions and offering expenses.

No warrants were exercised for equity capital proceeds in 2022, 2021 and 2020.

In 2022, 2021 and 2020, our capital expenditures have been financed mainly by cash and cash equivalents.

Amounts received from the Walloon Region, booked as advances repayable, correspond to funding received under several RCAs, dedicated to supporting specific development programs related to CAR T platform, THINK and DEPLETHINK (for CYAD-01), CYAD-02, CYAD-101, CYAD-203, CYAD-211 clinical studies, new engagers and C-Cath<sub>ez</sub> at the end of 2022.

The changes in the advances repayable balance recorded in 2022, 2021 and 2020 are summarized in the table below:

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| | |
|:---|:---|
| **(€'000)** | **(€'000)** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Balance of January 1, 2020** | **4 485** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; + liability recognition | 1 284 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; - repayments | (246) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; +/- other transactions including change of fair value | (933) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Balance at December 31, 2020** | **4 591** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; + liability recognition | 1 575 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; - repayments | (280) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; +/- other transactions including change of fair value | 328 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Balance at December 31, 2021** | **6 213** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; + liability recognition | 485 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; - repayments | (230) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; +/- other transactions including change of fair value | (1 447) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Balance at December 31, 2022** | **5 021** |

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#### Capital Expenditures
We do not capitalize our research and development expenses until we receive marketing authorization for the applicable product candidate. Accordingly, all clinical, research and development spend related to the development of our CAR T product candidates and allogeneic platform have been accounted for as operating expenses for the current year 2022, like for prior years.

Our capital expenditures, excluding impact of recognition of right-of-use assets, were €0.1 million, €0.3 million and €0.2 million for the years ended December 31, 2022, 2021 and 2020 respectively.

We expect our capital expenditures to increase in absolute terms in the near term as we continue to advance its research and development programs and will relocate its corporate offices in another location in Belgium through the year 2023.

The non-current assets are detailed in the following table.

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| | | | |
|:---|:---|:---|:---|
|  | **As of December 31,** | **As of December 31,** | **As of December 31,** |
| (€'000) | **2022** | **2021** | **2020** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Goodwill and Intangible assets | 864 | 36 168 | 36 171 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Property, plant and equipment | 309 | 3 248 | 4 119 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Other non-current assets | 3 718 | 6 235 | 6 089 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Total** | **4 891** | **45 651** | **46 379** |

---

The decrease in non-current assets observed at year-end 2022 compared to year-end 2021, is primarily the result of:

• As of December 31, 2022, Management, to comply with the accounting standards, had to conclude on the recognition of a full impairment loss on the remaining value of the goodwill, on the IPR&D and on the Exclusive Agreement for Horizon Discovery's shRNA Platform, which mainly explains the decrease of €35.3 million on Goodwill and Intangible assets;

• A decrease of €2.9 million on Property, plant and equipment mainly relates to equipment and furniture sales and depreciation after the transactions occurred with Cellistic; and

• A decrease in Other non-current assets mainly related to the settlement of the receivable to collect from Mesoblast in January 2022.

#### Contractual Obligation
During the periods presented, we had bank guarantees granted to the landlords of our Belgian and U.S. offices (€0.3 million). These bank guarantees will last until the termination of the respective lease agreements.

The table below analyses our non-derivative financial liabilities into relevant maturity groupings based on the remaining period at the statement of financial position date to the contractual maturity date. The amounts disclosed in the table are the contractual undiscounted cash flows, except for advances repayable which are presented at amortized cost.

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| | | | | | |
|:---|:---|:---|:---|:---|:---|
| (€'000) | **Total** | **Less than one<br>year** | **One to three<br>years** | **Three to five<br>years** | **More than five<br>years** |
|  **As at December 31, 2022** |  |  |  |  |  |
|  Lease liabilities (undiscounted) | 259 | 141 | 118 |  |  |
|  Bank loan |  |  |  |  |  |
|  Pension obligations | 13 |  |  |  | 13 |
|  Advances repayable (current and non-current) | 5 021 | 437 | 640 | 637 | 3 307 |
|  **Total financial liabilities** | **5 293** | **578** | **758** | **637** | **3 320** |

---

#### Operating Capital Requirements
As of December 31, 2022, we had cash and cash equivalents of €12.4 million and no short-term investments. We project that our existing cash and cash equivalents should be sufficient to fund operating expenses and capital expenditure requirements into the fourth quarter of 2023.

After due consideration of detailed budgets and estimated cash flow forecasts for the years 2023 and 2024, we project that our existing cash and cash equivalents will not be sufficient to fund its estimated operating and capital expenditures over at least the next 12 months from the date that the financial statements are issued.

We are currently evaluating different financing options to obtain the required funding to extend our cash runway beyond 12 months from the date the financial statements are issued. Financing options may include, but are not limited to, the public or private sale of equity, debt financings or funds from other capital sources, such as collaborations, strategic alliances and partnerships, or licensing arrangements with third parties. However, there can be no assurance that we will be able to secure additional financing, or if available, that it will be sufficient to meet our needs or available on favorable terms indicating a material uncertainty exists about our ability to continue as a going concern.

We have based this estimate on assumptions that may prove to be wrong, and we could use our capital resources sooner than we currently expect. In any event, we will require additional capital to pursue preclinical activities and develop our IP assets and enter into partnerships with outside parties.

Until we can generate a sufficient amount of revenue from our IP assets, if ever, we expect to finance our operating activities through a combination of equity offerings, debt financings, government, including RCAs and subsidies, or other third-party financings and collaborations. Additional capital may not be available on reasonable terms, if at all. If we are unable to raise additional capital in sufficient amounts or on terms acceptable to us, we may have to significantly delay, scale back or discontinue the development of one or more of our preclinical activities and IP assets. If we raise additional funds through the issuance of additional debt or equity securities, it could result in dilution to our existing shareholders, increased fixed payment obligations and these securities may have rights senior to those of our ordinary shares. If we incur indebtedness, we could become subject to covenants that would restrict our operations and potentially impair our competitiveness, such as limitations on our ability to incur additional debt, limitations on our ability to acquire, sell or license intellectual property rights and other operating restrictions that could adversely impact our ability to conduct our business. Any of these events could significantly harm our business, financial condition and prospects.

There are no legal or economic restrictions on the ability of our subsidiaries to transfer funds to Celyad Oncology SA in the form of cash dividends, loans or advances.

Our present and future funding requirements will depend on many factors, including, among other things:

• The costs involved in filing patent applications, maintaining and enforcing patents or defending against claims or infringements raised by third parties; and

• The amount of revenue, if any, we may derive either directly or in the form of royalty payments from future potential collaboration agreements on our technology platforms.

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##### [**Table of Contents**](#toc)
For more information as to the risks associated with our future funding needs, see the section of this Annual Report titled "Item 3.D.—Risk Factors".

C. Research and Development

For a discussion of our research and development activities, see "Item 4.B.—Business Overview" and "Item 5.A—Operating Results."

D. Trend Information

Other than as disclosed elsewhere in this annual report, we are not aware of any trends, uncertainties, demands, commitments or events for the period from January 1, 2022 to December 31, 2022 that are reasonably likely to have a material adverse effect on our net revenues, income, profitability, liquidity or capital resources, or that caused the disclosed financial information to be not necessarily indicative of future operating results or financial conditions. For a discussion of trends, see "Item 4.B.—Business Overview," "Item 5.A.—Operating Results" and "Item 5.B.—Liquidity and Capital Resources."

E. Critical Accounting Estimates

For information regarding our critical accounting estimates and judgments, please see "Note 5—Critical accounting estimates and judgements" in our consolidated financial statements appended to this Annual Report. The preparation of our consolidated financial statements requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosures of contingent assets and liabilities at the date of the consolidated financial statements and the reported amounts of revenues and expenses during the year. These items are considered further to be the accounting policies that are most critical to our results of operations, financial condition and cash flows.

F. Safe Harbor.

This Annual Report contains forward-looking statements within the meaning of Section 27A of the Securities Act and Section 21E of the Exchange Act and as defined in the Private Securities Litigation Reform Act of 1995. See "Special Note Regarding Forward-Looking Statements."

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| | |
|:---|:---|
| **ITEM 6.** | **DIRECTORS, SENIOR MANAGEMENT AND EMPLOYEES**  |

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**A. Directors and Senior Management.** 

#### Board of Directors
As provided by the articles 7:85 et sq. of the CCA, we are managed by a Board of Directors acting as a collegiate body. The Board of Directors' role is to pursue our long-term success by providing entrepreneurial leadership and enabling risks to be assessed and managed. The Board of Directors determines our values and strategy, its risk preference and key policies. The Board of Directors ensures that the necessary leadership, financial and human resources are in place for us to meet its objectives.

We have opted for a one-tier governance structure. As provided by Article 7:93 of the CCA, the Board of Directors is our ultimate decision-making body, except with respect to those areas that are reserved by the law or by our articles of association to the Shareholders Meeting.

Our articles of association state that the number of our directors, who may be natural persons or legal entities and who need not be shareholders, must be at least three. At least half of the members of the Board of Directors must be non-executive directors and at least three of them must be independent directors.

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A meeting of the Board of Directors is validly constituted if at least half of its members are present in person or represented at the meeting. If that quorum is not met, a new board meeting may be convened by any director to deliberate and decide on the matters on the agenda of the board meeting for which a quorum was not met, provided that at least two members are present. Meetings of the Board of Directors are convened by the Chairperson of the Board or by at least two directors, whenever our interest so requires. In principle, the Board of Directors will meet at least four times per year.

The Chairperson of the Board of Directors shall have a casting vote on matters submitted to the Board of Directors in the event of a tied vote.

Until such time as the Fortress Shareholders (which shall have the meaning ascribed to it in that certain shareholders' rights agreement dated as of December 2, 2021 by and between CFIP CLYD LLC and the Company, in the form filed with the United States Securities and Exchange Commission on December 3, 2021) own in the aggregate less than 10% of the then outstanding shares (including shares underlying American Depositary Shares) for a period of more than thirty (30) consecutive days:

(i) Fortress Investment Group LLC ("Fortress") shall have the right to select two (2) individuals (the "Fortress Designees") to be, at Fortress's option, (a) members of the Board, (b) non-voting observers of the Board or (c) a combination thereof (provided that if Fortress selects both Fortress Designees to be members of the Board, Fortress may also select a third Fortress Designee to be a non-voting observer of the Board), and

(ii) the Board, at Fortress's option, (a) shall recommend the confirmation or (re)appointment of any two (2) Fortress Designees as members of the Board at any applicable general meeting of shareholders of the Company, (b) shall appoint any two (2) Fortress Designees as non-voting observers of the Board or (c) shall proceed to a combination thereof, and

(iii) Upon the termination of the board mandate of any Fortress Designee (for whatever cause), at the option of Fortress, (a) the Company shall as soon as practicably possible co-opt to the Board a replacement Fortress Designee, and shall use best efforts to cause the confirmation of the co-optation at the next general meeting of shareholders of the Company; or (b) the Company shall as soon as practicably possible approve the appointment of a replacement Fortress Designee as a non-voting observer of the Board of Directors, and

(iv) the Company shall not, directly or indirectly, without the consent of recommend, directly or indirectly, or take any action to (a) increase the size of the Board or (b) co-opt or appoint to the Board, in place of the Fortress Designees, any individual other than a Fortress Designee.

At the date of this Report, the Board of Directors consists of 7 members, one of which is an executive director (with daily management authority) and 6 of which are non-executive directors, including three independent directors. The Board of Directors is composed of 4 men and 3 women.

---

| | | | |
|:---|:---|:---|:---|
| **Name** | **Position** | **Term** | **Board Committee Membership** |
| Mel Management SRL (1) | Executive Director | 2025 |  |
| Serge Goblet | Non-executive director | 2024 |  |
| Christopher LiPuma (2) | Non-executive director | 2024 | Member of the Nomination and Remuneration Committee |
| Hilde Windels | Independent director | 2026 | Chair of the Board<br> Member of the Audit Committee and Chair of the Nomination and Remuneration Committee |
| Ami Patel Shah (3) | Non-Executive Director | 2024 |  |
| Dominic Piscitelli | Independent Director | 2024 | Chairman of the Audit Committee and member of the Nomination and Remuneration Committee |
| Marina Udier | Independent Director | 2025 | Member of the Audit Committee |

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*(1)* *Represented by Michel Lussier.* 

*(2)* *Christopher LiPuma has been elected as Board member as of January 20, 2022, in replacement of RAD Lifesciences BV who resigned from the Board on January 14, 2022.* 

*(3)* *Ami Patel Shah has been elected as Board member on December 7, 2021 in replacement of Maria Koehler who has resigned from the Board of Directors on August 5, 2021.* 

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##### [**Table of Contents**](#toc)
The following paragraphs contain brief biographies of each of the directors, or in case of legal entities being director, their permanent representatives, with an indication of other relevant mandates as member of administrative, management or supervisory bodies in other companies during the previous five years.

**Hilde Windels** serves as Chair of the Board of Directors since June 2022. Hilde Windels is an advisor in the life sciences industry. She brings over 20 years of experience in biotech with a track record of business and corporate strategy, building and structuring organizations, private fundraising, mergers and acquisitions and public capital markets. Ms. Windels has worked as Chief Financial Officer for several biotech companies, amongst those Belgium based molecular Dx company Biocartis where she started as Chief Financial Officer CFO in 2011. She transitioned to the co-Chief Executive Officer role in 2015 and became interim Chief Executive Officer in 2017. She took up the CEO role of MyCartis in early 2018 and of its spin-out Antelope Dx mid-2019. Ms. Windels is a member of the board of directors of Erytech, GIMV and MdxHealth. She holds a Master's Degree in Economics (Commercial Engineer) from the University of Leuven (Belgium).

**Michel Lussier** is ad interim Chief Executive Officer of the Company. Mr. Lussier co-founded Cardio3 Biosciences SA the company which became Celyad SA. Mr. Lussier currently serves also on several Boards of Directors: iSTAR Medical SA and Gabi Smart Care SA as Chairman, Occlutech AG as board member. Previously, Mr. Lussier founded MedPole SA and its North American affiliate Medpole LTD, a Medtech and cell therapy incubator for start-up companies, serving as CEO until July 2020. From May 2014 and until September 2020, Mr. Lussier also served as the CEO of Metronom Health Inc, an early stage medical device company founded by Fjord Ventures, where he also acted as a management consultant. Mr. Lussier served as a member of the Board of Directors of Biological Manufacturing Services SA until 2017. Prior to that, from 2002 to 2013, he worked for Volcano Corporation, where he served in global leadership positions. Mr. Lussier started his career with Medtronic where he held a number of technical, marketing, sales then general management roles. Mr. Lussier obtained a Bachelor of Sciences degree in Electrical Engineering and Master's Degree in Biomedical Engineering at the University of Montreal. He also holds an MBA from INSEAD, France.

**Serge Goblet** holds a Master Degree in Business and Consular Sciences from ICHEC, Belgium and has many years of international experience as director in Belgian and foreign companies. Mr. Goblet is the managing director of TOLEFI SA, a Belgian holding company and holds director mandates in subsidiaries of TOLEFI.

**Dominic Piscitelli** brings more than 20 years of industry experience, including debt and equity financings, in-licensing transactions, acquisitions, marketing partnerships and commercial product launches (XTANDI<sup>®</sup> and Tarceva<sup>®</sup>). Since September 2019 Dominic has served as the Chief Financial Officer of ORIC Pharmaceuticals, Nasdaq-listed biotechnology company, that completed its initial public offering in April 2020. Prior to joining ORIC, Mr. Piscitelli was CFO of AnaptysBio, a Nasdaq-listed biotechnology company, where he helped raise over $500 million in an IPO and follow-on financings. From 2012 until 2017, Mr. Piscitelli was Vice President of Finance, Strategy and Investor Relations at Medivation and played a key role in its acquisition by Pfizer. Previously, he served as Senior Director of Collaborations and Operations Finance at Astellas Pharma. Prior to that, Mr. Piscitelli served in various roles of increasing responsibility culminating as the Vice President, Treasury & Management Finance at OSI Pharmaceuticals, and played a significant role in their acquisition by Astellas. Mr. Piscitelli began his career with KPMG and is a certified public accountant. He earned a bachelor's degree in accounting and an MBA from Hofstra University (New York).

**Marina Udier, Ph.D.,** serves as CEO of Nouscom after joining as Chief Operating Officer in 2016 from Versant Ventures, where she was Operating Principal. Prior to Versant, she held senior development and commercial roles at Novartis in Basel including work as a Global Commercial Head. Previously, Dr. Udier worked for McKinsey & Company in the US, working with Healthcare Fortune 500 companies in areas of marketing, strategy and pricing. She has a Ph.D. in Organic Chemistry from Yale University.

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##### [**Table of Contents**](#toc)
**Ami Patel Shah** is a Managing Director in Fortress Investment Group LLC's Intellectual Property Group based in San Francisco, where she focuses on a wide variety of investment opportunities in connection with intellectual property and technology. Prior to joining Fortress in 2013, Ms. Shah worked for Intel, most recently heading Intel's Global Wireless Patents group, overseeing the Intel's patent procurement, licensing, transaction and monetization activities for Intel and their development partners. At Intel, Ms. Shah also held wide-ranging and deep technical responsibilities, as well as led Intel's standards bodies interactions. Before joining Intel, she was with the law firms of Dorsey & Whitney, and Fish & Richardson where she worked on patent prosecution, licensing and ITC litigation matters. Ms. Shah is recognized as one of the World's Leading IP Strategists by Intellectual Asset Magazine in the IAM 300, awarded to individuals with an established track record in developing and rolling out world-class IP value creation programs. Ms. Shah began her legal career as an examiner in the United States Patent Office and was an engineer in the auto industry. Ms. Shah holds a J.D. from Cleveland State University along with a B.S. in Electrical and Computer Engineering from Wayne State University.

**Christopher LiPuma** is a Director in Fortress Investment Group LLC's Intellectual Property Group based in San Francisco, where he focuses on a wide variety of investment opportunities in connection with intellectual property, life sciences, and academic institutions. Prior to joining Fortress in 2018, Mr. LiPuma headed business development for Kastle Therapeutics, a private equity backed biotechnology company acquiring ultra-orphan drugs. Before joining Kastle, Mr. LiPuma was with OrbiMed Advisors, a life sciences focused asset management firm. At OrbiMed, Mr. LiPuma worked on royalty monetizations, direct lending to late development stage and early commercial stage life sciences companies, and several private equity transactions focused on acquiring legacy assets from big pharma. Mr. LiPuma started his career as an investment banker at Leerink Partners. Mr. LiPuma holds a B.A. from Hamilton College.

#### The Executive Committee
The Board of Directors has established an Executive Committee. The terms of service of the Executive Committee have been determined by the Board of Directors and are set out in our Charter.

The Executive Committee consists of the Chief Executive Officer, or CEO (who is the chairman of the Executive Committee), the Vice President of Finance and Administration (VP Finance), the Director of R&D, the Head of IP, the Head of Legal and the Vice President Human Resources.

The Executive Committee discusses and consults with the Board of Directors and advises the Board of Directors on our day-to-day management in accordance with our values, strategy, general policy and budget, as determined by the Board of Directors.

Each member of the Executive Committee has been made individually responsible for certain aspects of our day-to-day management and our business (in the case of the CEO, by way of delegation by the Board of Directors; in the case of the other member of the Executive Committee, by way of delegation by the CEO). The further tasks for which the Executive Committee is responsible are described in greater detail in the sections referencing the Executive Committee, as set out in our Charter.

The members of the Executive Committee are appointed and may be dismissed by the Board of Directors at any time. The Board of Directors appoints them following the recommendation of the Nomination and Remuneration Committee, which shall also assist the Board of Directors on the remuneration policy of the members of the Executive Committee, and their individual remunerations.

The remuneration, duration and conditions of dismissal of Executive Committee members is governed by the contract entered into between us and each member of the Executive Committee with respect to their function within us.

In principle, the Executive Committee meets every month. Additional meetings may be convened at any time by the Chairman of the Executive Committee or at the request of two of its members. The Executive Committee will constitute a quorum when all members have been invited and the majority of the members are present or represented at the meeting. Absent members may grant a power of attorney to another member of the Executive Committee. Members may attend the meeting physically or by telephone or video conference. The absent members must be notified of the discussions in their absence by the Chairman (or our Secretary, if the Executive Committee has appointed a Company Secretary from among its members).

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The members of the Executive Committee must provide the Board of Directors with information in a timely manner, if possible, in writing, on all facts and developments concerning the Company that the Board of Directors may need in order to function as required and to properly carry out its duties. The CEO (or, in the event that the CEO is not able to attend the Board of Directors' meeting, the VP Finance & Administration, in the event that the VP Finance & Administration is not able to attend the Board of Directors' meeting, another representative of the Executive Committee) must report at every ordinary meeting of the Board of Directors on the material deliberations of the previous meeting(s) of the Executive Committee.

The following table sets forth the members of the Executive Committee who have performed during 2022.

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| | | |
|:---|:---|:---|
| Name | Function | Year of birth |
| Filippo Petti(1) | Chief Executive Officer and Chief Financial Officer | 1976 |
| Mel Management SRL, represented by Michel Lussier | Chief Executive Officer | 1956 |
| Charles Morris(2) | Chief Medical Officer | 1965 |
| NandaDevi SRL, represented by Philippe Dechamps(3) | Chief Legal Officer and Corporate Secretary | 1970 |
| MC Consult SRL, represented by Philippe Nobels | Chief Human Resources Officer | 1966 |
| ImXense SRL, represented by Frederic Lehmann(4) | Vice President Clinical Development & Medical Affairs | 1964 |
| Stephen Rubino(5) | Chief Business Officer | 1958 |
| David Gilham(6) | Chief Scientific Officer | 1965 |
| F&C Consulting SRL, represented by David Georges | Vice President Finance and Administration | 1976 |
| Eytan Breman | Director Research and Development | 1980 |
| Hannes Iserentant | Head of IP | 1978 |
| An Phan | Heal of Legal | 1975 |

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(1) The collaboration between the Company and Filippo Petti was terminated on June 24, 2022.

(2) The mandate of Chief Legal Officer of NandaDevi SRL was terminated on October 31, 2022 but NandaDevi continues his mandate as Corporate Secretary since November 1, 2022

(3) The collaboration between the Company and ImXense SRL was terminated on July 29, 2022.

(4) The collaboration between the Company and Stephen Rubino was terminated on April 1, 2022.

(5) The collaboration between the Company and David Gilham was terminated on June 24, 2022.

The following paragraphs contain brief biographies of each of the current members of the Executive Committee or in case of legal entities being a member of the Executive Committee or key manager, their permanent representatives.

**Michel Lussier (representative of Mel Management SRL), CEO ad interim** – reference is made to section "2.2.1. Composition of the Board of Directors".

**David Georges (representative of F&C Consulting SRL),** brings more than 20 years of experience in the life sciences industry holding various financial and administration roles. David first joined Celyad Oncology in January 2019 as Finance Director and was appointed VP of Finance and Administration in June 2022. He started his career in the bank and insurance sector working for Axa Royale Belge and the Citibank's EMEA headquarters, where he had the opportunity to evolve in different financial roles including accounting, tax and financial consolidation. From there, he worked as a financial manager for the pharmaceutical Merck KGaA where he held responsibilities for financial controlling, procurement and supply chain as well as holding an active role on the finance integration of acquired company Serono. Before joining Celyad Oncology, David served as Finance and Administration Director and then CFO of DIAsource ImmunoAssays, a privately held Belgian infectious disease company where he played a key role in M&A activities with AnteoTech and Biovendor. David holds a bachelor's degree in Economy and a postgraduate degree in Finance from the University of Louvain.

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**Philippe Nobels (representative of MC Consult SRL),** serves as Vice President of Human Resources of the Company. He started his career at Price Waterhouse (now PricewaterhouseCoopers) as auditor in 1989. He also went in rotational assignment in Congo during 2 years on consulting missions for the World Bank. In 1995, he joined Fourcroy as plant controller. Then, he joined Dow Corning in 1997 where he held different positions in Finance and Human Resources. He led the HR operations in Europe, became the HR manager for Dow Corning in Belgium, and HR Business Partner for the sales and marketing functions globally. As a member of the sales and marketing Leadership teams, he contributed to Dow Corning's major transformation initiatives to increase organizational effectiveness, employees' engagement & performance as well as Business results. Mr. Nobels holds a Master's Degree in Economics from the University of Namur.

**Eytan Breman,** first joined Celyad Oncology as a R&D Project Leader in 2015 and has also held positions as a senior scientist and R&D Manager of the discovery group at the Company. As of June 2022, Eytan became Head of R&D, heading the implementation of our research and development strategy for both the current and future CAR T therapies we are developing. Prior to working at Celyad Oncology, he started his career as an engineer in the laboratory of immunology at the academic hospital of Maastricht in 2007. He then obtained a Masters in Biopharmaceutical Sciences from the University of Leiden and a PhD in transplant immunology from the University of Antwerp. He was awarded The Anthony P. Monaco Award for his work in the transplant field in 2014.

**Hannes Iserentant**, serves as Head of Intellectual Property (IP) of the Company. He first joined Celyad Oncology as IP Director in 2016 and has held positions including Senior Director of IP and Senior Director of R&D at the Company. He started his IP career in private practice at Bird Goën & Co as a member of the life sciences team before moving to VIB, a research institute active in all areas of life sciences. He was a founding member of VIB's technology watch team involved in identifying and securing access to early stage, emerging technologies. From 2013 to 2016, he was appointed as a member of the "Expert Group on the development and implications of patent law in the field of biotechnology and genetic engineering" for the European Commission. Mr. Iserentant holds a PhD in Biomedical Sciences from Ghent University and is a qualified European Patent Attorney.

**An Phan,** joined Celyad Oncology in September 2021 as Senior Legal Director and was appointed as Head of Legal in July 2022. An brings more than 20 years of legal experience with a strong focus on Life Sciences and Compliance, as well as a proven record of providing strategically sound counsel in highly regulated businesses. An began her law career in international law firms. In 2004, she joined Johnson & Johnson as Senior Legal Counsel providing legal support to all J&J businesses mainly in the Middle East and Africa. Seven years later, An served as Legal Director EMEA for St. Jude Medical for eight years, where she was supporting the whole region of Europe, Middle East and Africa. Following the acquisition of St. Jude Medical by Abbott, An moved to Hill-Rom as Compliance Director Europe & MEATI located in Amsterdam. Prior to Celyad, An worked as General Counsel for De Smet SA Engineering & Contractors in Belgium supporting their operations worldwide. An holds a Master in Laws from the UCLouvain (Belgium) and a postgraduate certification in International and European Tax Law from the "Ecole Supérieure des Sciences Fiscales" (Brussels, Belgium).

#### Family Relationships
There are no family relationships among any of the members of our Executive Committee or directors.

B. Compensation

The aggregate compensation paid and benefits in kind granted by us to the current members of our Executive Committee and directors, including share-based compensation, for the year ended December 31, 2022, was €4.48 million. For the year ended December 31, 2022, approximately €53,000 of the amounts set aside or accrued to provide pension, retirement or similar benefits to our employees was attributable to members of our Executive Committee.

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For a discussion of our employment arrangements with members of our Executive Committee and consulting arrangements with our directors, see the section of this Annual Report titled "Item 7.B.—Related Party Transactions—Agreements with our Directors and Members of our Executive Committee." For more information regarding warrant grants, see the section of this report titled "—Warrant Plans."

Except the arrangements described in the section of this Annual Report titled "Certain relationships and related party transactions-Agreements with our Directors and Members of our Executive Committee," there are no arrangements or understanding between us and any our other executive officers or directors providing for benefits upon termination of their employment, other than as required by applicable law.

There are no agreements or contracts between the directors and the members of the Executive Committee and us or any of our subsidiaries providing for benefits for the directors upon termination of employment or services agreements in place that provide for benefits upon termination of employment.

#### Compensation of Our Board of Directors
The Company's remuneration policy is aimed at attracting non-executive directors with the most relevant skills, knowledge and expertise in a highly competitive and quickly evolving industry. The policy will help the Company attract and retain a diverse and international team of non-executive directors, striking a balance between scientific, financial, operational and strategic contributions, promoting an open, fair, sustainable and equitable company culture, driven by success.

The remuneration of the non-executive Directors is determined by the shareholders' meeting upon proposal of the Board of Directors based on a recommendation from the Nomination and Remuneration Committee. The Nomination and Remuneration Committee benchmarks non-executive Directors' compensation against peer companies to ensure that it remains fair and competitive. The Directors' remunerations are therefore market driven.

The remuneration policy is based on the following fixed components:

(a) A fixed fee, consisting of a base fee and an additional fee if the non-executive director is the Chairman of the Board or any of its Committees or if the non-executive Director is a member of a Board Committee; and

(b) Warrants.

The remuneration of non-executive Directors does not contain any variable part and is not based on any performance conditions. As the Company has no distributable reserves, it does not meet the legal requirements to proceed to a shares buy-back, therefore does not own treasury shares and is then currently unable to grant shares to the non-executive directors as part of their remuneration.

<u>Fixed fee</u> 

The fixed fee of non-executive directors consists of:

(a) A fixed annual fee (retainer) of 18,000 EUR (36,000 EUR for the Chairman of the Board), including the four annual, ordinary Board meetings;

(b) A supplemental fixed fee of 3,000 EUR (5,000 EUR for the Chairman of the Board) for the participation to extraordinary Board meetings of more than 2 hours, and 1,500 EUR (2,500 for the Chairman of the Board) for the participation to extraordinary Board meetings of less than 2 hours;

(c) A supplemental fixed annual fee (retainer) of 15,000 EUR for membership of each Committee of the Board of Directors, increased by 5,000 EUR for the Chairmanship of such Committee;

(d) An extraordinary fee of €3,000 for specific assignments to a non-executive director, on request of the CEO and with prior approval of the Board of Directors.

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The Board fees are paid in quarterly installments at the end of each subsequent calendar quarter. The Company will also reimburse out-of-pocket expenses (such as, without limitation, travel, meals and lodging expenses) incurred by directors in direct relation with their Board duties.

<u>Warrants</u> 

The Board has determined that the grant of warrants to non-executive or independent directors is in the best interest of the Company to attract and retain highly skilled directors in a very dynamic and competitive environment. The grant of warrants is a commonly used remuneration instrument in the sector in which the Company operates, in particular in the United States where the Company is active. In addition, the Company is not entitled to own treasury shares and is currently unable to offer any remuneration in shares. Finally, the grant of warrants provides an attractive additional remuneration without impacting the Company's cash. Without this possibility, the Company would be subject to a considerable disadvantage compared to competitors offering warrants to their non-executive directors.

The grant of warrants is not linked or subject to any performance conditions and consequently, does not qualify as variable remuneration.

The warrants are usually issued by decision of the Board of Directors within the framework of the authorized capital (but can also be issued by decision of the Shareholders' Meeting). The warrants are then offered to non-executive directors by decision of the Board of Directors upon recommendation of the Nomination and Remuneration Committee. Conflict of interest procedure applies to such decision of the Board. Each warrant gives its holder the right (but not the obligation) to subscribe, under the exercise conditions, during the exercise periods and against payment of the exercise price, to one Company's share.

Company's warrants are granted for a limited term. This term is determined by the Board of Directors, in compliance with the CCA, with a maximum of ten years. The warrants have a vesting period of minimum three (3) years and may be exercised to the extent vested. Shares obtained through the exercise of warrants are freely transferrable.

The exercise price is equal to the fair market value of the Company's shares at the time of the offer. This value is determined by the Board of Directors and corresponds to either the closing price of the Company's share on the day before the date of the offer or the average of the thirty (30) calendar days preceding the date of the Offer of the closing price of the Company's Share.

The warrants can be immediately exercised by the beneficiaries in the following situations:

(a) Share capital increase in cash without suspension of the preferential rights of the existing shareholders;

(b) Takeover bid on the shares of the company as of the announcement of the public offer by the FSMA;

(c) Change of control on the company;

(d) Conclusion of a "strategic partnership" with an important industrial actor, active in the life-science sector, and if the "strategic partnership" is qualified as such by the board of directors.

For further details on the terms and conditions of our warrants plans, we refer to the plans available on our website and as may be amended from time to time.

The Directors' mandate may be terminated "ad nutum" (at any time) without any form of compensation. There is no specific agreement between the Company and non-executive directors which waives or restrains the right of the Company to terminate "ad nutum" (at any time) the mandates of the directors.

On May 5, 2021, at a meeting of our shareholders, the shareholders approved the terms and conditions of a template of warrants plan to comply with in the event of an implementation of such plan in the next 12 months, upon proposal of the nomination and remuneration committee, with a vesting period of 3 years and for which the exercise price will be the lowest between (i) the average of the closing price of the share in the 30 days preceding the offer and (ii) the last closing price of the share on the date preceding the offer. More specifically, the Shareholders Meeting approved a clause of anticipated vesting in the event of a change of control or a public offering on our shares.

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On October 5, 2022, we issued 323,700 subscription rights under the terms and conditions approved by the shareholders at the meeting held on May 5, 2022.

We do not plan to amend the principles driving our remuneration policy in the near future and in particular in the next two financial years.

As of December 31, 2022, there are no loans outstanding from us to any member of the Board of Directors.

There are no employment or service agreements that provide for notice periods or indemnities between us and any member of the Board of Directors who is not a member of the Executive Committee.

The following table sets forth the fees received by our non-executive Directors for the performance of their duties as a Board Member, during the year ended December 31, 2022:

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| | |
|:---|:---|
| **Name** | **Fees Earned (€)** |
|  Michel Lussier | 45 500 |
|  Serge Goblet | 30 000 |
|  Chris Buyse | 36 000 |
|  Hilde Windels | 81 000 |
|  Dominic Piscitelli | 69 500 |
|  Marina Udier | 49 500 |
|  Chris Li Puma | 42 000 |
|  Ami Patel Shah | 28 500 |
|  **Total** | **382 000** |

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The table below provides an overview of the warrants held by the non-executive directors as of December 31, 2022.

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| | | | |
|:---|:---|:---|:---|
|  | **Warrant Awards** | **Warrant Awards** | **Warrant Awards** |
| **Name** | **Number of Ordinary Shares<br>Underlying Warrants** | **Warrant Exercise Price<br>in euros** | **Warrant Expiration<br>Date** |
|  Michel Lussier | 10 000 | 22.04 | December 31, 2024 |
|  | 10 000 | 8.16 | December 31, 2024 |
|  | 10 000 | 8.80 | December 31, 2025 |
|  | 10 000 | 6.73 | December 31, 2027 |
|  | 10 000 | 6.49 | December 31, 2028 |
|  | 10 000 | 3.75 | December 31, 2028 |
|  | 10 000 | 2.14 | December 31, 2029 |
|  Serge Goblet | 10 000 | 22.04 | December 31, 2024 |
|  | 10 000 | 8.16 | December 31, 2024 |
|  | 10 000 | 5.97 | December 31, 2025 |
|  | 10 000 | 6.73 | December 31, 2027 |
|  | 10 000 | 3.75 | December 31, 2028 |
|  Hilde Windels | 10 000 | 22.04 | December 31, 2023 |
|  | 10 000 | 8.16 | December 31, 2024 |
|  Piscitelli Dominic | 10 000 | 7.93 | December 31, 2025 |
|  | 10 000 | 6.73 | December 31, 2027 |
|  | 10 000 | 6.49 | December 31, 2028 |
|  | 10 000 | 3.75 | December 31, 2028 |
|  | 10 000 | 2.14 | December 31, 2029 |
|  Marina Udier | 10 000 | 6.73 | December 31, 2027 |
|  | 10 000 | 6.49 | December 31, 2028 |
|  | 10 000 | 3.75 | December 31, 2028 |
|  | 10 000 | 2.14 | December 31, 2029 |
|  **Total** | **230 000** |  |  |

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##### [**Table of Contents**](#toc)

#### Compensation of Members of the Executive Committee
The compensation of the members of our Executive Committee is determined by our Board of Directors based on the recommendations by our Nomination and Remuneration Committee.

The remuneration of the members of our Executive Committee consists of different components:

• Fixed remuneration: a basic fixed fee designed to fit responsibilities, relevant experience and competences, in line with market rates for equivalent positions. The amount of fixed remuneration is evaluated and determined by the Board of Directors every year.

• Short-term variable remuneration: members of the Executive Committee may be entitled to a yearly bonus, given the level of achievement of the criteria set out in the corporate objective for that year.

• Incentive plan: warrants have been granted and may be granted in the future, to the members of the Executive Committee. For a description of the main characteristics of our warrant plans, see the section of this Annual report titled "—Warrant Plans."

• Other: members of the Executive Committee with an employee contract with us are entitled to participate in our pension, company car and payments for invalidity and healthcare cover and other fringe benefits of non-material value.

No loans, quasi-loans or other guarantees were granted to members of our Executive Committee during the year ended on December 31, 2022.

The following table sets forth information concerning the aggregate compensation earned during the year ended December 31, 2022, by the other members of our Executive Committee, including the CEO.

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| | |
|:---|:---|
|  | **Compensation (in kEuros)** |
|  Fixed remuneration (gross) | 2 061 |
|  Variable remuneration (short-term) | 233 |
|  Fixed fee | 912 |
|  Variable fee | 289 |
|  Pension/Life | 53 |
|  Other benefits | 142 |
|  **Total** | **3 690** |

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##### [**Table of Contents**](#toc)
The table below provides an overview of the warrants held by the members of our Executive Committee as of December 31, 2022.

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| | | | |
|:---|:---|:---|:---|
|  | **Warrant Awards** | **Warrant Awards** | **Warrant Awards** |
| **Name** | **Number of Ordinary<br>Shares Underlying<br>Warrants** | **Warrant Exercise Price<br>in euros** | **Warrant Expiration<br>Date** |
|  Michel Lussier<sup>1</sup> | 300 000 | 1.64 | December 31, 2029 |
|  Philippe Nobels<sup>2</sup> | 10 000 | 22.04 | December 31, 2024 |
|  | 20 000 | 8.16 | December 31, 2024 |
|  | 20 000 | 5.97 | December 31, 2025 |
|  | 10 000 | 6.49 | December 31, 2028 |
|  | 20 000 | 3.75 | December 31, 2028 |
|  | 30 000 | 1.64 | December 31, 2029 |
|  Charles Morris | 125 000 | 5.42 | December 31, 2028 |
|  | 20 000 | 3.75 | December 31, 2028 |
|  | 30 000 | 2.14 | December 31, 2029 |
|  David Georges<sup>3</sup> | 3 000 | 18.10 | December 31, 2024 |
|  | 5 750 | 8.16 | December 31, 2024 |
|  | 7 000 | 5.97 | December 31, 2025 |
|  | 5 000 | 6.73 | December 31, 2027 |
|  | 7 000 | 6.49 | December 31, 2028 |
|  | 7 000 | 3.75 | December 31, 2028 |
|  | 9 700 | 2.14 | December 31, 2029 |
|  An Phan | 5 000 | 3.75 | December 31, 2028 |
|  Hannes Iserentant | 5 000 | 32.60 | November 4, 2025 |
|  | 3 000 | 21.16 | December 31, 2023 |
|  | 7 000 | 18.10 | December 31, 2024 |
|  | 15 000 | 8.16 | December 31, 2024 |
|  | 5 000 | 5.97 | December 31, 2025 |
|  | 5 000 | 6.73 | December 31, 2027 |
|  | 7 000 | 6.49 | December 31, 2028 |
|  | 7 000 | 3.75 | December 31, 2028 |
|  Eytan Breman | 700 | 45.05 | May 15, 2024 |
|  | 1 500 | 34.65 | November 5, 2025 |
|  | 2 000 | 18.10 | December 31, 2024 |
|  | 2 000 | 8.16 | December 31, 2024 |
|  | 1 750 | 5.97 | December 31, 2025 |
|  **TOTAL** | **696 400** |  |  |

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[1] Michel Lussier personally holds these warrants, although he is the representative of Mel Management SRL, his management company, which has been appointed as Interim Chief Executive Officer.

[2] Philippe Nobels personally holds these warrants, although he is the representative of MC Consult SRL, his management company, which has been appointed as Chief Human Resources Officer.

[3] David Georges personally holds these warrants, although he is the representative of F&C Consulting SRL, his management company, which has been appointed as Vice President of Finance and Administration.

#### Limitations on Liability and Indemnification Matters
Under Belgian law, the directors of a company may be liable for damages to us in case of improper performance of their duties. Our directors may be liable to us and to third parties for infringement of our articles of association or Belgian company law. Under certain circumstances, directors may be criminally liable.

We maintain liability insurance for our directors and officers, including insurance against liability under the Securities Act.

Certain of our non-executive directors may, through their relationships with their employers or partnerships, may be insured and/or indemnified against certain liabilities in their capacity as members of our Board of Directors.

In the underwriting agreements we entered into in connection with our June 2015, May 2018 and September 2019 global offerings, the underwriters agreed to indemnify, under certain conditions, us, the members of our Board of Directors and persons who control our company within the meaning of the Securities Act (the "Indemnitees") against certain liabilities, but only to the extent that such liabilities are caused by information relating to the underwriters furnished to us in writing expressly for use in the our registration statement and certain other disclosure documents. The sales agreement we entered into in connection with our September 2020 "at the market" offering contained substantially similar indemnification provisions in which our sales agent agreed to indemnify the Indemnitees.

#### Warrant Plans
We have created various incentive plans under which warrants were granted to our employees, consultants or directors. This section provides an overview of the outstanding warrants as of December 31, 2022.

Upon proposal of the Board of Directors, the extraordinary shareholders' meeting approved the issuance of, in the aggregate, warrants giving right to subscribe to shares as follows:

• On May 6, 2013, warrants giving right to 266,241 ordinary shares. Out of the 266,241 warrants offered, 253,150 Warrants were accepted by the beneficiaries and 2,500 warrants are outstanding as of December 31, 2022.

• On June 11, 2013, overallotment warrant giving right to a maximum number of shares equal to 15% of the new shares issued in the context of the U.S. initial public offering, i.e., 207,225 shares). The overallotment warrant was exercised on July 17, 2013;

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• On May 5, 2014, warrants giving right to 100,000 shares; a plan of 100,000 warrants was approved. Warrants were offered to Company's newcomers (employees, non-employees and directors) in several tranches. Out of the warrants offered, 94,400 warrants were accepted by the beneficiaries and 35,698 warrants are outstanding as of December 31, 2022.

• On November 5, 2015, warrants giving right to 466,000 shares; a plan of 466,000 warrants was approved. Warrants were offered to Company's newcomers (employees, non-employees and directors) in several tranches. Out of the warrants offered, 353,550 warrants were accepted by the beneficiaries and 79,315 warrants are outstanding as of December 31, 2022.

• On December 8, 2016, warrants giving right to 100,000 shares; a plan of 100,000 warrants was approved. Warrants were offered to Company's newcomers (employees, non-employees and directors) in two tranches. Out of the warrants offered, 45,000 warrants were accepted by the beneficiaries and 7,500 warrants are outstanding as of December 31, 2022.

• On June 29, 2017, warrants giving right to 520,000 shares; a plan of 520,000 warrants was approved. Warrants were offered to employees, non-employees and directors in several tranches. Out of the warrants offered, 334,400 warrants were accepted by the beneficiaries. None are outstanding as of December 31, 2022.

• On October 26, 2018, warrants giving rights to 700,000 shares; 700,000 warrants have been issued in the framework of the authorized capital. 426,050 warrants were accepted by the beneficiaries, out of which 365,817 warrants are still outstanding as of December 31, 2022.

• On October 25, 2019, warrants giving rights to 939,500 shares; 939,500 warrants have been issued in the framework of the authorized capital. 602,025 warrants were accepted by the beneficiaries, out of which 529,950 warrants are still outstanding as of December 31, 2022.

• On December 11, 2020, warrants giving rights to 561,525 shares; 561,525 warrants have been issued in the framework of the authorized capital. 557,050 warrants were accepted by the beneficiaries, out of which 498,883 warrants are still outstanding as of December 31, 2022.

• On October 11, 2021, warrants giving rights to 777,050 shares; 777,050 warrants have been issued in the framework of the authorized capital. 874,200 warrants were accepted by the beneficiaries, out of which 819,983 warrants are still outstanding as of December 31, 2022;

• On October 5, 2022, warrants giving rights to 323,700 shares; 323,700 warrants have been issued in the framework of the authorized capital. No warrants were accepted yet by the beneficiaries. None are outstanding as of December 31, 2022.

As a result, as of December 31, 2022 there are 2,339,646 warrants outstanding which represent respectively 9.38% of the total number of all its issued and outstanding shares and 8.57% of the total voting financial instruments.

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| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| **Issue Date** | **Term** | **Number of<br>Warrants<br>Issued<sup>1</sup>** | **Number of<br>Warrants<br>Granted<br>in number<br>of shares<sup>2</sup>** | **Exercise<br>Price (in<br>Euros)** | **Number of<br>Warrants No<br>Longer<br>Exercisable** | **Warrants<br>exercised** | **Number of<br>Warrants<br>Outstanding** | **Exercise periods vested<br>warrants<sup>3</sup>** |
|  May 6, 2013 | From May 6, 2013 to May 6, 2023 | 266 241 | 253 150 | 264 | 21 050 | 229 600 | 2 500 | From January 1, 2017 to May 6, 2023 May 2018 for non-employees and to May 6, 2023 for employees |
|  May 5, 2014 | From May 16, 2014 to May 15, 2024 | 100 000 | 94 400 | From 33.49 to<br>45.05 | 58 702 |  | 35 698 | From January 1, 2018 to May 15, 2019 for non- employees and to May 15, 2024 for employees |
|  November 5, 2015 | From November 5, 2015 to November 4, 2025 | 466 000 | 353 550 | From 15.90 to<br>34.65 | 274<br>235 |  | 79 315 | From January 1, 2019 to November 4, 2020 for non-employees and to November 4, 2025 for employees |
|  December 12, 2016 | From December 9, 2016 to December 31, 2021 | 100 000 | 45 000 | From 17.60 to<br>36.81 | 37 500 |  | 7 500 | From January 1, 2020 to December 31, 2021 |
|  May 5, 2017 | From July 20, 2017 to July 31, 2022 | 520 000 | 334 400 | From 31.34 to<br>48.89 | 334<br>400 |  |  | From January 1, 2021 to July 31, 2022 |
|  October 26, 2018 | From October 26, 2018 to October 25, 2023 | 700 000 | 426 050 | From 9.36 to<br>22.04 | 60 233 |  | 365 817 | From January 1, 2022 to December 31, 2023 |
|  October 25, 2019 | From October 25, 2019 to October 24, 2024 | 939 500 | 602 025 | From 5.97 to<br>9.84 | 72 075 |  | 529 950 | From January 1, 2023 to December 31, 2024 |
|  December 10, 2020 | From December 10, 2020 to December 9, 2027 | 561 525 | 557 050 | From 3.72 to<br>6.81 | 58 167 |  | 498 883 | From January 1, 2024 to December 31, 2027 |
|  October 11, 2021 | From October 11, 2021 to October 10, 2028 | 777 050 | 874 200 | From 1.64 to<br>3.75 | 54 217 |  | 819 983 | From January 1, 2025 to December 31, 2028 |

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[1] Issued under the condition precedent of the warrant effectively being offered and accepted.

[2] The numbers reflect the number of shares for which the holder of warrants can subscribe upon exercise of all relevant warrants.

[3] The warrants (i) can only be exercised by the holder of warrants if they have effectively vested, and (ii) can only be exercised during the exercise periods as set out in the respective issue and exercise conditions.

Apart from the warrants and warrant plans, we do not currently have other stock options, options to purchase securities, convertible securities or other rights to subscribe for or purchase securities outstanding.

C. Board Practices

Our Board of Directors can set up specialized committees to analyze specific issues and advise the Board of Directors on those issues.

The committees are advisory bodies only and the decision-making remains within the collegial responsibility of the Board of Directors. The Board of Directors determines the terms of service of each committee with respect to the organization, procedures, policies and activities of the committee.

Our Board of Directors has set up and appointed an Audit Committee and a Nomination and Remuneration Committee. The composition and function of all of our committees will comply with all applicable requirements of the CCA, the Belgian Corporate Governance Code, the Exchange Act, the applicable rules of the NASDAQ Stock Market and SEC rules and regulations.

#### Audit Committee
At the date of this Annual Report, our Audit Committee consists of three members: Dominic Piscitelli (Chairman), Marina Udier and Hilde Windels.

The role of the Audit Committee is to ensure the effectiveness of the internal control and risk management systems, the internal audit (if any) and its effectiveness and the statutory audit of the annual and consolidated accounts, and to review and monitor the independence of the external auditor, in particular regarding the provision of additional services to us. The Audit Committee reports regularly to the Board of Directors on the exercise of its functions. The Audit Committee informs the Board of Directors about all areas in which action or improvement is necessary in its opinion and produces recommendations concerning the necessary steps that need to be taken. The audit review and the reporting on that review cover us and its subsidiaries as a whole. The members of the Audit Committee are entitled to receive all information which they need to perform their function from the Board of Directors, Executive Committee and employees. Each member of the Audit Committee shall exercise this right in consultation with the Chairman of the Audit Committee.

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##### [**Table of Contents**](#toc)
The Audit Committee's duties and responsibilities include, among other things: the financial reporting, the review of internal controls and risk management, and managing the internal and external audit process. Those tasks are further described in the Audit Committee charter as set out in the Charter and in the Article 7:99 §4 of the CCA.

Dominic Piscitelli and Hilde Windels have been identified by our Board of Directors as having the necessary expertise in accounting and audit matters to serve as experts on the Audit Committee.

The Audit Committee holds a minimum of four meetings per year.

#### Nomination and Remuneration Committee
As of the date of this Report, the Nomination and Remuneration Committee is composed of three members: Hilde Windels (Chair), Christopher LiPuma and Dominic Piscitelli.

The Nomination and Remuneration Committee consists of not less than three directors, or such greater number as determined by the Board of Directors at any time. All members must be non-executive directors and at least a majority of its members must be independent in accordance with Article 7:87 of the CCA. Our Board of Directors has determined that Hilde Windels and Dominic Piscitelli are independent in accordance with Article 7:87 of the CCA.

The Nomination and Remuneration Committee must have the necessary expertise as regards the remuneration policy, and this condition is fulfilled if at least one member has had a higher education and has had at least three years of experience in personnel management or in the field of remunerating directors and managers. As of the date of this Annual Report, Hilde Windels (Chair), Christopher LiPuma and Dominic Piscitelli satisfy this requirement.

The CEO has the right to attend the meetings of the Nomination and Remuneration Committee in an advisory and non-voting capacity on matters other than those concerning himself. The Nomination and Remuneration Committee will elect a chairman from amongst its members. The Chair of the Nomination and Remuneration Committee is actually Hilde Windels.

The role of the Nomination and Remuneration Committee is to assist the Board of Directors in all matters:

• Relating to the selection and recommendation of qualified candidates for membership of the Board of Directors;

• Relating to the nomination of the CEO;

• Relating to the nomination of the members of the Executive Committee, other than the CEO, upon proposal by the CEO;

• Relating to the remuneration of independent directors;

• Relating to the remuneration of the CEO;

• Relating to the remuneration of the members of the Executive Committee, other than the CEO, upon proposal by the CEO;

• On which the Board of Directors or the Chairman of the Board of Directors requests the Nomination and Remuneration Committee's advice.

Additionally, with regard to matters relating to remuneration, except for those areas that are reserved by law to the Board of Directors, the Nomination and Remuneration Committee will at least have the following tasks:

• Preparing the remuneration report (which is to be included in the Board of Director's corporate governance statement); and

• Explaining its remuneration report at the Annual General Shareholders Meeting.

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It will report to the Board of Directors on the performance of these tasks on a regular basis. These tasks are further described in the terms of reference of the Nomination and Remuneration Committee as set out in the Charter. The Nomination and Remuneration Committee will meet at least twice per year, and whenever it deems it necessary to carry out its duties.

D. Employees

As of December 31, 2022, we employed 28 full-time employees, 3 part-time employees, 7 members of the Executive Committee (among them 3 are under management services agreement), and 1 manager under management services agreements. We have never had a work stoppage We consider our relationship with our employees to be good.

The following tables set forth the distribution of our employees, members of the Executive Committee and managers under service agreements by main department and geography for the years ended December 31, 2022, 2021 and 2020.

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| | | | |
|:---|:---|:---|:---|
|  | **At December 31,** | **At December 31,** | **At December 31,** |
|  | **2022** | **2021** | **2020** |
|  **By function:** |  |  |  |
|  Clinical & Regulatory, IP, Marketing | 16 | 23 | 17 |
|  Research & Development | 12 | 29 | 27 |
|  Manufacturing /Quality | 1 | 33 | 32 |
|  General Administration | 10 | 18 | 17 |
|  **Total** | **39** | **103** | **92** |
|  **By Geography:** |  |  |  |
|  Belgium | 34 | 95 | 88 |
|  United States | 5 | 8 | 4 |
|  **Total** | **39** | **103** | **92** |

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E. Share Ownership

For information regarding the share ownership of our directors and executive officers and arrangements for involving our employees in our capital, see "Item 6.B—Compensation" and "Item 7.A—Major Shareholders."

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| | |
|:---|:---|
| **ITEM 7.** | **MAJOR SHAREHOLDERS AND RELATED PARTY TRANSACTIONS**  |

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A. Major shareholders

The following table sets forth information with respect to the beneficial ownership of our ordinary shares as of February 28, 2023 for:

• Each person who is known by us to own beneficially more than 5% of our outstanding ordinary shares;

• Each member of our board of directors;

• Each member of our executive committee; and

• All members of our board of directors and executive committee as a group.

Beneficial ownership is determined in accordance with the rules of the SEC. These rules generally attribute beneficial ownership of securities to persons who possess sole or shared voting power or investment power with respect to those securities and include ordinary shares that can be acquired within 60 days of February 28, 2023. The percentage ownership information shown in the table is based upon 22,593,956 ordinary shares outstanding as of February 28, 2023.

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Except as otherwise indicated, all of the shares reflected in the table are ordinary shares and all persons listed below have sole voting and investment power with respect to the shares beneficially owned by them, subject to applicable community property laws. The information is not necessarily indicative of beneficial ownership for any other purpose.

In computing the number of ordinary shares beneficially owned by a person and the percentage ownership of that person, we deemed outstanding ordinary shares subject to warrants held by that person that are immediately exercisable. We did not deem these shares outstanding, however, for the purpose of computing the percentage ownership of any other person. The information in the table below is based on information known to us or ascertained by us from public filings made by the shareholders. Except as otherwise indicated in the table below, addresses of the directors, members of the Executive Committee and named beneficial owners are in care of Rue Edouard Belin 2, 1435 Mont-Saint-Guibert, Belgium.

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| | | |
|:---|:---|:---|
| **NAME OF BENEFICIAL OWNER** | **SHARES BENEFICIALLY OWNED** | **SHARES BENEFICIALLY OWNED** |
| **5% Shareholders** | **Number** | **Percentage** |
|  CFIP CLYD LLC (affiliate of Fortress Investment Group) | 6 500 000 | 28.77% |
|  TOLEFI SA | 2 295 701 | 10.16% |
|  **Directors and Members of the Executive Management Team** |  |  |
|  Michel Lussier<sup>1</sup> | 156 550 | 0.69% |
|  Serge Goblet | 56 180 | 0.25% |
|  **All directors and members of the executive management team as a group** | **212 730** | **0.94%** |

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[1] Of which 145,150 are ordinary shares and 11,400 are ADSs.

All shares are issued and fully paid up and are of the same class. Each share (i) entitles its holder to one vote at the Shareholders' Meetings (except for what is said below regarding shares with double voting rights); (ii) represents an identical fraction of the capital and has the same rights and obligations and participates equally in the profit of the Company; and (iii) gives its holder a preferential subscription right to subscribe to new shares, convertible bonds or warrants in proportion to the part of the share capital represented by the shares already held.

As from May 3, 2021, Tolefi SA, a major shareholder of the Company, has been entitled to a double voting right for its 2,295,701 shares.

We are not aware of any arrangement that may, at a subsequent date, result in a change of control of our company.

As of February 28, 2023, the two main shareholders are CFIP CLYD LLC (who holds 28.77% of the shares and 26.04% of the voting rights) and TOLEFI SA (who holds 10.16% of the shares and 18.39 % of the voting rights). As a consequence, the two main shareholders of the Company hold together 44.43 % of the voting rights attached to the shares of the Company.

As of February 28, 2023, assuming that all of our ordinary shares represented by ADSs are held by residents of the United States, we estimate that approximately 6.48% of our outstanding ordinary shares were held in the United States by one registered holder of record. The actual number of holders is greater than these numbers of record holders and includes beneficial owners whose ADSs are held in street name by brokers and other nominees. This number of holders of record also does not include holders whose shares may be held in trust by other entities.

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#### Change in Ownership of Major Shareholders
Not applicable.

B. Related Party Transactions

Since January 1, 2021, we have not engaged in any transactions with our directors, executive officers and holders of more than 5% of our outstanding voting securities and their affiliates, which we refer to as its related parties.

As of December 31, 2022, there were no outstanding loans, nor guarantees made by us or our subsidiaries to or for the benefit of any related party.

#### Transactions with Our Principal Shareholders
We have not engaged in any transactions with our principal shareholders.

#### Agreements with Our Directors and Members of Our Executive Committee

#### Management Services Arrangements
*Michel Lussier* 

Mel Management SRL, represented by Michel Lussier, our Interim Chief Executive Officer, was engaged on the basis of a services agreement with an effective date of June 24, 2022 and an indefinite term. Pursuant to this agreement, Mel Management SRL is entitled to an annual fee and an annual grant of warrants.

*Philippe Dechamps* 

NandaDevi SRL, represented by Philippe Dechamps, our former Chief Legal Officer, was engaged on the basis of a services agreement with an effective date of September 1, 2016 and an indefinite term. Pursuant to this agreement, NandaDevi SRL was entitled to an annual fee and Mr. Dechamps was also eligible to receive a bonus capped at 30% of his annual fees, determined in full discretion by the Board of Directors on the basis of the performance of NandaDevi SRL and the company overall. NandaDevi SRL was also eligible to receive warrants. This services agreement was terminated on October 31, 2022, but Mr. Dechamps has continued to serve as our Corporate Secretary since November 1, 2022.

Effective November 1, 2022, NandaDevi SRL was engaged on the basis of a separate services agreement with an indefinite term. Pursuant to this agreement, NandaDevi SRL is entitled to an annual fee.

*Philippe Nobels* 

MC Consult SRL, represented by Philippe Nobels, our former VP Human Resources, was engaged on the basis of a services agreement with an effective date of January 3, 2017 and an indefinite term. Pursuant to this agreement, MC Consult SRL was entitled to an annual fee and was also eligible to receive a bonus capped at 30% of Mr. Nobels' annual fees, determined in full discretion by the Board of Directors on the basis of the performance of MC Consult SRL and the company overall. MC Consult SRL was also eligible to receive warrants. This services agreement was terminated on February 28, 2023.

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*David Georges* 

F&C Consulting SRL, represented by David Georges, our Vice President of Finance and Administration, was engaged on the basis of a services agreement with an effective date of September 28, 2018 and an indefinite term. Pursuant to this agreement, as amended, F&C Consulting SRL is entitled to an annual fee and is also eligible to receive a bonus capped at 30% of Mr. Georges' annual fees, determined in full discretion by the Board of Directors on the basis of the performance of F&C Consulting SRL and the company overall. F&C Consulting SRL is also eligible to receive warrants.

#### Director and Executive Committee Compensation
See "Item 6.B.—Compensation" for information regarding compensation of directors and members of our Executive Committee.

#### Warrants
Since our inception, we have granted warrants to certain of our directors and members of our Executive Committee. See "Item 6.B.—Compensation" for information regarding warrants issued to members of our Executive Committee and directors.

#### Indemnification Agreements
In connection with our global offering in June 2015, May 2018 and September 2019, we entered into indemnification agreements with each of our directors and members of our Executive Committee. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers or persons controlling us pursuant to the foregoing provisions, we has been informed that in the opinion of the SEC such indemnification is against public policy as expressed in the Securities Act and is therefore unenforceable.

#### Transactions with Related Companies

#### Related Party Transactions Policy
Article 7:97 of the CCA provides for a special procedure that applies to intra-group or related party transactions with affiliates. The procedure will apply to decisions or transactions between us and our that are not our subsidiaries. It will also apply to decisions or transactions between any of our subsidiaries and such subsidiaries' affiliates that are not our subsidiary.

Prior to any such decision or transaction, our Board of Directors must appoint a special committee consisting of three independent directors, assisted by one or more independent experts. This committee provides the Board of Directors with a written report explaining the rationale for the decision on the proposed transaction, addressing at least the following elements: the nature of the decision or the transaction, a description and an estimation of the equity consequences, a description of the eventual other consequences, and the advantages and disadvantages resulting therefrom for us. The committee puts the proposed decision or transaction in the context of our strategy and determines if it causes any prejudice to us, if it is compensated by other elements of that strategy, or if it is manifestly abusive. The remarks of the expert are included in the opinion of the committee.

The Board of Directors must then make a decision, taking into account the opinion of the committee. Any deviation from the committee's advice must be explained. Directors who have a conflict of interest are not entitled to participate in the deliberation and vote. The committee's advice and the decision of the Board of Directors must be communicated to our Statutory Auditor, who must render a separate opinion. The conclusion of the committee, an excerpt from the minutes of the Board of Directors and the opinion by the Statutory Auditor must be included in the (statutory) annual report of the Board of Directors.

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The procedure does not apply to decisions or transactions in the ordinary course of business at customary market conditions, and transactions or decisions with a value of less than 1% of the consolidated net assets of the Company.

In 2022, there was no transaction with affiliates except the termination effective October 1, 2022, of the Interco service contract between the Company and its affiliate Biological Manufacturing Services dated 11 April 2011, following the sale of the Company's Cell Therapy Manufacturing Unit to Cellistic, the cell therapy development and manufacturing business of Ncardia Belgium BV.

In addition, our Charter provides for guidelines for transactions between us and our directors or members of our Executive Committee. According to such guidelines,

A member of our Board of Directors or Executive Committee will in any event be considered to have a conflict of interests if:

• He/she has a personal financial interest in a company with which we intend to enter into a transaction;

• He/she, his/her spouse, registered partner or other life companion, foster child or relative by blood or marriage up to the second degree is a member of the executive management of or board of a company with which we intend to enter into a transaction;

• He/she is a member of the board or executive management of, or holds similar office with, a company with which we intend to enter into a transaction;

• Under applicable law, including the rules of any stock market on which our shares may be listed, such conflict of interests exists or is deemed to exist.

Each member of the Board of Directors or each member of the Executive Committee must immediately report any potential conflict of interests to the chairman and to the other members of the Board of Directors or of the Executive Committee, as the case may be. The members concerned must provide the chairman and the other members of the Board of Directors or of Executive Committee, as the case may be, with all information relevant to the conflict, including information relating to the persons with whom he has a family law relationship (his/her spouse, registered partner or other life companion, foster child or relative by blood or marriage up to the second degree) to the extent relevant for the assessment of the existence of a conflict of interests. The chairman of the Board of Directors or of the Executive Committee will determine whether a reported (potential) conflict of interests qualifies as a conflict of interests.

If this is the case, a member of the Board of Directors or of the Executive Committee, as the case may be, must not participate in the discussions or decision-taking process of the Board of Directors or of the Executive Committee, as the case may be, on a subject or transaction in relation to which he has a conflict of interests with us. This transaction, if approved, must be concluded on term customary in the sector concerned and be approved, in the case of a decision by the Executive Committee, by the Board of Directors. Without prejudice to the foregoing, each member of the Board of Directors who is faced, directly or indirectly, with a financial interest that conflicts with a decision or transaction within the competence of the Board of Directors, within the meaning of 7:96 of the CCA , as the case may be, must inform the other members of the Board of Directors thereof prior to the deliberations. The declaration, as well as the justification, must be included in the minutes of the relevant meeting of the Board of Directors.

We must inform the statutory auditor of his conflict of interests.

With a view to publication in the annual report, the Board of Directors must set out in its minutes the nature of the decision or transaction and the justification thereof, including the financial consequences of the decision or transaction for us. In the case of a conflict of interests within the Executive Committee, a copy of the minutes of the Executive Committee must be submitted to the Board of Directors at its next meeting. The chairman must procure that all these transactions involving conflicts of interests will be referred to in the annual report, with a declaration that the provisions in our Charter have been complied with.

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C. Interest of Experts and Counsel

Not applicable.

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| **ITEM 8.** | **FINANCIAL INFORMATION**  |

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A. Consolidated Statements and Other Financial Information Consolidated Financial Statements

Our consolidated financial statements are appended at the end of this Annual Report, starting at page F-1, and incorporated herein by reference.

#### Dividend Policy
We have never declared or paid any cash dividends on our ordinary shares. We do not anticipate paying cash dividends on our equity securities in the foreseeable future and intend to retain all available funds and any future earnings for use in the operation and expansion of our business. All of the ordinary shares, including in the form of the ADSs, offered by this report will have the same dividend rights as all of our other outstanding ordinary shares. In general, distributions of dividends proposed by our Board of Directors require the approval of our shareholders at a meeting of shareholders with a simple majority vote, although our Board of Directors may declare interim dividends without shareholder approval, subject to the terms and conditions of the CCA.

Pursuant to Belgian law, the calculation of amounts available for distribution to shareholders, as dividends or otherwise, must be determined on the basis of our non-consolidated statutory financial accounts prepared under Belgian GAAP, and not on the basis of IFRS consolidated accounts. In addition, under the CCA, we may declare or pay dividends only if, following the declaration and issuance of the dividends, the amount of our net assets on the date of the closing of the last financial year according to the our statutory annual accounts (i.e., the amount of the assets as shown in the balance sheet, decreased with provisions and liabilities, all as prepared in accordance with Belgian accounting rules), decreased with the non-amortized costs of incorporation and expansion and the non-amortized costs for research and development, does not fall below the amount of the paid-up capital (or, if higher, the called capital), increased by the amount of non-distributable reserves. Finally, prior to distributing dividends, we must allocate at least 5% of our annual net profits (under our non-consolidated statutory accounts prepared in accordance with Belgian accounting rules) to a legal reserve, until the reserve amounts to 10% of our share capital.

For information regarding the Belgian withholding tax applicable to dividends and related U.S. reimbursement procedures, see "Item 10.E.—Taxation—Belgian Tax Consequences."

#### Legal Proceedings
From time to time, we may become involved in legal proceedings or be subject to claims arising in the ordinary course of our business. Except as disclosed in relation to the Horizon/PKI dispute, we are not presently a party to any legal proceedings that, if determined adversely to us, would individually or taken together have a material adverse effect on our business, results of operations, financial condition or cash flows. Regardless of the outcome, litigation can have an adverse impact on us because of defense and settlement costs, diversion of management resources and other factors.

B. Significant Changes

Not applicable.

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| **ITEM 9.** | **THE OFFER AND LISTING**  |

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A. Offer and Listing Details

The ADSs have been listed on NASDAQ under the symbol "CYAD" since June 19, 2015. Prior to that date, there was no public trading market for ADSs. Our ordinary shares have been trading on Euronext Brussels and Euronext Paris under the symbol "CYAD" since July 5, 2013. Prior to that date, there was no public trading market for ADSs or our ordinary shares.

B. Plan of Distribution

Not applicable.

C. Markets.

The ADSs have been listed on the Nasdaq under the symbol "CYAD" since June 19, 2015 and the ordinary shares have been listed on the Euronext Brussels and Euronext Paris under the symbol "CYAD" since July 5, 2013.

D. Selling Shareholders

Not applicable.

E. Dilution

Not applicable.

F. Expenses of the Issue

Not applicable.

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| **ITEM 10.** | **ADDITIONAL INFORMATION**  |

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A. Share Capital

Not applicable.

B. Memorandum and Articles of Association

The information set forth in our Registration Statement on Form F-3 (File No. 333-248464), originally filed with the SEC on August 28, 2020 and declared effective by the SEC on September 4, 2020, under the headings "Description of Share Capital and Articles of Association" and "Description of Securities" is incorporated herein by reference.

C. Material Contracts

On September 3, 2020, we entered into an Open Market Sale Agreement<sup>SM</sup> with Jefferies LLC ("Jefferies") pursuant to which we may from time to time sell, for a period of up to 36 months, through "an at the market offering" ("ATM"), with Jefferies acting as sales agent, up to $25,000,000 of new American Depositary Shares ("ADSs"), each of which represents one of our ordinary shares, assuming sales of 2,522,704 ADSs in the offering at an offering price of $9.91 per ADS, which was the last reported sale price of the ADSs on the Nasdaq Global Market on September 8, 2020.

On January 8, 2021, we entered into a committed equity purchase agreement ("Purchase Agreement") for up to $40.0 million with Lincoln Park Capital Fund, LLC ("LPC"), a Chicago-based institutional investor. Over the 24-month term of the Purchase Agreement, we will have the right to direct LPC to purchase up to an aggregate amount of $40.0 million American Depositary Shares ("ADSs"), each of which represents one of our ordinary shares. On January 8, 2023, the Purchase Agreement has been terminated.

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For additional information on our material contracts, please see the sections of this Annual Report titled "Item 4.B.—Business Overview—Licensing and Collaboration Agreements" and "Item 7—Major Shareholders and Related Party Transactions."

On December 2, 2021, we entered into a Subscription Agreement (the "Subscription Agreement") with CFIP CLYD LLC, an affiliate of Fortress Investment Group, pursuant to which we agreed to sell to Fortress, in an unregistered offering, an aggregate of 6,500,000 ordinary shares at a purchase price of $5.00 per share (the "Private Placement"). The Private Placement closed on December 8, 2021 and resulted in the receipt of gross proceeds of approximately $32,500,000. In connection with the Subscription Agreement, we also entered into a Shareholders' Rights Agreement (the "Shareholders' Rights Agreement") with Fortress, pursuant to which Fortress (i) has the right to select two individuals to be, at Fortress's option, either members of our Board of Directors (the "Board") or non-voting observers of the Board, so long as Fortress continues to hold at least 10% of our outstanding ordinary shares; and (ii) received a right of first offer on any new indebtedness to be incurred by us and a pro rata right of first refusal on any new equity securities to be issued by us, as well as customary registration rights. We also granted Fortress certain protective provisions related to our intellectual property portfolio.

D. Exchange Controls

#### Exchange Controls and Limitations Affecting Shareholders
There are no Belgian exchange control regulations that impose limitations on our ability to make, or the amount of, cash payments to residents of the United States.

We are in principle under an obligation to report to the National Bank of Belgium certain cross-border payments, transfers of funds, investments and other transactions in accordance with applicable balance-of-payments statistical reporting obligations. Where a cross-border transaction is carried out by a Belgian credit institution on our behalf, the credit institution will in certain circumstances be responsible for the reporting obligations.

E. Taxation

#### Material Income Tax Considerations
The information presented under the caption "Certain Material U.S. Federal Income Tax Considerations to U.S. Holders" below is a discussion of certain material U.S. federal income tax considerations to a U.S. holder (as defined below) of investing in ADSs. The information presented under the caption "Belgian Tax Consequences" is a discussion of the material Belgian tax consequences of investing in ADSs.

You should consult our tax advisor regarding the applicable tax consequences to you of investing in ADSs under the laws of the United States (federal, state and local), Belgium, and any other applicable foreign jurisdiction.

#### Certain Material U.S. Federal Income Tax Considerations to U.S. Holders
The following is a summary of certain material U.S. federal income tax considerations relating to the acquisition, ownership and disposition of ADSs by a U.S. holder (as defined below). This summary addresses only the U.S. federal income tax considerations for U.S. holders that are initial purchasers of the ADSs pursuant to the offering and that will hold such ADSs as capital assets for U.S. federal income tax purposes (generally, property held for investment). This summary does not address all U.S. federal income tax matters that may be relevant to a particular U.S. holder. This summary does not address tax considerations applicable to a holder of ADSs that may be subject to special tax rules including, without limitation, the following:

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• Banks, financial institutions or insurance companies;

• Brokers, dealers or traders in securities, currencies, commodities, or notional principal contracts;

• Tax-exempt entities or organizations, including an "individual retirement account" or "Roth IRA" as defined in section 408 or 408A of the Code (as defined below), respectively;

• Real estate investment trusts, regulated investment companies or grantor trusts;

• Persons that hold the ADSs as part of a "hedging," "integrated" or "conversion" transaction or as a position in a "straddle" for U.S. federal income tax purposes;

• Partnerships (including entities and arrangements classified as partnerships for U.S. federal income tax purposes) or other pass-through entities, or persons that will hold the ADSs through such an entity;

• Certain former citizens or long-term residents of the United States;

• Persons required under section 451(b) of the Code to conform the timing of income accruals with respect to the ADSs to their financial statements;

• Persons who acquired the ADSs pursuant to the exercise of any employee stock option or otherwise as compensation;

• Holders that own (directly, indirectly, or through attribution) 10% or more of the voting power or value of the ADSs and shares; and

• Holders that have a "functional currency" for U.S. federal income tax purposes other than the U.S. dollar.

Further, this summary does not address the U.S. federal estate, gift, or alternative minimum tax considerations, or any U.S. state, local, or non-U.S. tax considerations of the acquisition, ownership and disposition of the ADSs.

This description is based on the U.S. Internal Revenue Code of 1986, as amended, or the Code; existing, proposed and temporary U.S. Treasury Regulations promulgated thereunder, administrative and judicial interpretations thereof, and the Convention between the Government of the United States and the Government of the Kingdom of Belgium for the Avoidance of Double Taxation and the Prevention of Fiscal Evasion with Respect to Taxes on Income, signed on November 27, 2006, or the U.S.-Belgium Tax Treaty, in each case as of and available as of the date hereof. All the foregoing is subject to change, which change could apply retroactively, and to differing interpretations, all of which could affect the tax considerations described below. There can be no assurances that the U.S. Internal Revenue Service, or IRS, will not take a contrary or different position concerning the tax consequences of the acquisition, ownership and disposition of the ADSs or that such a position would not be sustained. Holders should consult their own tax advisors concerning the U.S. federal, state, local and non-U.S. tax consequences of owning and disposing of the ADSs in their particular circumstances.

For the purposes of this summary, a "U.S. holder" is a beneficial owner of ADSs that is (or is treated as), for U.S. federal income tax purposes:

• An individual who is a citizen or resident of the United States;

• A corporation, or other entity that is treated as a corporation for U.S. federal income tax purposes, created or organized in or under the laws of the United States, any state thereof, or the District of Columbia;

• An estate, the income of which is subject to U.S. federal income taxation regardless of its source; or

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• A trust, (1) if a court within the United States is able to exercise primary supervision over its administration and one or more U.S. persons have the authority to control all of the substantial decisions of such trust or (2) if the trust has a valid election in effect under applicable U.S. Treasury Regulations to be treated as a United States person.

If a partnership (or any other entity or arrangement treated as a partnership for U.S. federal income tax purposes) holds ADSs, the U.S. federal income tax consequences relating to an investment in the ADSs will depend in part upon the status of the partner and the activities of the partnership. Such a partner or partnership should consult its tax advisor regarding the U.S. federal income tax considerations of owning and disposing of the ADSs in its particular circumstances.

The discussion below assumes that the representations contained in the deposit agreement are true and that the obligations in the deposit agreement and any related agreement will be complied with in accordance with their terms. In general, a U.S. holder who owns ADSs will be treated as the beneficial owner of the underlying shares represented by those ADSs for U.S. federal income tax purposes. Accordingly, no gain or loss will generally be recognized if a U.S. holder exchanges ADSs for the underlying shares represented by those ADSs.

As indicated below, this discussion is subject to U.S. federal income tax rules applicable to a "passive foreign investment company," or a PFIC, and assumes that we are not classified as a PFIC in any taxable year, except as specifically noted.

**Persons considering an investment in the ADSs should consult their own tax advisors as to the particular tax consequences applicable to them relating to the acquisition, ownership and disposition of the ADSs, including the applicability of U.S. federal, state and local tax laws and non-U.S. tax laws.** 

*Distributions*. Although we do not currently plan to pay dividends, and subject to the discussion under "—Passive Foreign Investment Company Considerations" below, the gross amount of any distribution (before reduction for any amounts withheld in respect of Belgian withholding tax) actually or constructively received by a U.S. holder with respect to ADSs will be taxable to the U.S. holder as a dividend to the extent of the U.S. holder's pro rata share of our current and accumulated earnings and profits as determined under U.S. federal income tax principles. Distributions in excess of earnings and profits will be non-taxable to the U.S. holder to the extent of, and will be applied against and reduce, the U.S. holder's adjusted tax basis in the ADSs. Distributions in excess of earnings and profits and such adjusted tax basis will generally be taxable to the U.S. holder as capital gain as described below under "—Sale, Exchange or Other Taxable Disposition of the ADSs." However, since we do not calculate our earnings and profits under U.S. federal income tax principles, it is expected that any distribution will be reported as a dividend, even if that distribution would otherwise be treated as a non-taxable return of capital or as capital gain under the rules described above. Non-corporate U.S. holders may qualify for the preferential rates of taxation with respect to dividends on ADSs applicable to long-term capital gains (*i.e.*, gains from the sale of capital assets held for more than one year) applicable to qualified dividend income (as discussed below) if we are a "qualified foreign corporation" and certain other requirements are met. A non-U.S. corporation (other than a corporation that is classified as a PFIC for the taxable year in which the dividend is paid or the preceding taxable year) generally will be considered to be a qualified foreign corporation (a) if it is eligible for the benefits of a comprehensive tax treaty with the United States which the Secretary of Treasury of the United States determines is satisfactory for purposes of this provision and which includes an exchange of information provision, or (b) with respect to any dividend it pays on ADSs which are readily tradable on an established securities market in the United States. The ADSs are listed on the Nasdaq Global Market, or NASDAQ, which is an established securities market in the United States, and we expect the ADSs to be readily tradable on NASDAQ. However, there can be no assurance that the ADSs will be considered readily tradable on an established securities market in the United States in future years. We are incorporated under the laws of Belgium, and we believe that we qualify as a resident of Belgium for purposes of, and are eligible for the benefits of the U.S.-Belgium Tax Treaty, although there can be no assurance in this regard. Further, the IRS has determined that the U.S.-Belgium Tax Treaty is satisfactory for purposes of the qualified dividend rules and that it includes an exchange-of-information program. Dividends received by a corporate U.S. holder will not be eligible for the dividends-received deduction generally allowed to corporate U.S. holders.

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A U.S. holder generally may claim the amount of any Belgian withholding tax as either a deduction from gross income or a credit against U.S. federal income tax liability. However, the foreign tax credit is subject to numerous complex limitations that must be determined and applied on an individual basis. Generally, the credit cannot exceed the proportionate share of a U.S. holder's U.S. federal income tax liability that such U.S. holder's "foreign source" taxable income bears to such U.S. holder's worldwide taxable income. In applying this limitation, a U.S. holder's various items of income and deduction must be classified, under complex rules, as either "foreign source" or "U.S. source." In addition, this limitation is calculated separately with respect to specific categories of income. For foreign tax credit limitation purposes, distributions paid on ADSs that are treated as dividends will generally be foreign source income and will generally constitute passive category income. Furthermore, Belgian income taxes that are withheld in excess of the rate applicable under the U.S.-Belgium Tax Treaty (for U.S. holders that are eligible for reduced rates under the U.S.-Belgium Tax Treaty) or that are refundable under Belgian law will not be eligible for credit against a U.S. holder's federal income tax liability. Each U.S. holder should consult its own tax advisors regarding the foreign tax credit rules.

In general, the amount of a distribution paid to a U.S. holder in a foreign currency will be the U.S. dollar value of the foreign currency calculated by reference to the spot exchange rate on the day the U.S. holder actually or constructively receives the distribution, regardless of whether the foreign currency is converted into U.S. dollars at that time. The U.S. holder will take a tax basis in the foreign currency equal to their U.S. dollar equivalent on such date. The conversion of the foreign currency into U.S. dollars at a later date will give rise to foreign currency exchange gain or loss equal to the difference between the foreign currency's U.S. dollar equivalent at such later time and the U.S. holder's tax basis in the foreign currency. Any foreign currency gain or loss that a U.S. holder recognizes on a subsequent conversion of foreign currency into U.S. dollars will be U.S. source ordinary income or loss. If a distribution received in a foreign currency is converted into U.S. dollars on the day they are received, a U.S. holder should not be required to recognize foreign currency gain or loss in respect of the distribution.

*Sale, Exchange or Other Taxable Disposition of the ADSs*. A U.S. holder will generally recognize gain or loss for U.S. federal income tax purposes upon the sale, exchange or other taxable disposition of ADSs in an amount equal to the difference between the U.S. dollar value of the amount realized from such sale, exchange or other taxable disposition and the U.S. holder's adjusted tax basis for those ADSs. Subject to the discussion under "—Passive Foreign Investment Company Considerations" below, this gain or loss will generally be a capital gain or loss. The adjusted tax basis in the ADSs generally will be equal to the cost of such ADSs. Capital gain from the sale, exchange or other taxable disposition of ADSs of a non-corporate U.S. holder is generally eligible for a preferential rate of taxation applicable to capital gains, if the non-corporate U.S. holder's holding period determined at the time of such sale, exchange or other taxable disposition for such ADSs exceeds one year (*i.e.*, such gain is long-term taxable gain). The deductibility of capital losses for U.S. federal income tax purposes is subject to limitations. Any such gain or loss that a U.S. holder recognizes generally will be treated as U.S. source income or loss for foreign tax credit limitation purposes.

*Medicare Tax*. Certain U.S. holders that are individuals, estates or trusts are subject to a 3.8% tax on all or a portion of their "net investment income," which may include all or a portion of their dividend income and net gains from the disposition of ADSs. Each U.S. holder that is an individual, estate or trust is urged to consult its tax advisors regarding the applicability of the Medicare tax to its income and gains in respect of its investment in the ADSs.

*Passive Foreign Investment Company Considerations*. A corporation organized outside the United States generally will be classified as a PFIC for U.S. federal income tax purposes in any taxable year in which, after applying certain look-through rules with respect to the income and assets of its subsidiaries, either: (i) at least 75% of its gross income is "passive income" or (ii) at least 50% of the average quarterly value of its total gross assets (which is measured by the fair market value of its assets, and for which purpose the total value of its assets may be determined in part by reference to the market value of the ADSs and its ordinary shares, which is subject to change) is attributable to assets that produce "passive income" or are held for the production of "passive income."

Passive income for this purpose generally includes dividends, interest, royalties, rents, gains from commodities and securities transactions, the excess of gains over losses from the disposition of assets which produce passive income, and includes amounts derived by reason of the temporary investment of cash, including the funds raised in offerings of the ADSs. If a non-U.S. corporation owns directly or indirectly at least 25% by value of the stock of another corporation, the non-U.S. corporation is treated for purposes of the PFIC tests as owning its proportionate share of the assets of the other corporation and as receiving directly its proportionate share of the other corporation's income. If we are a PFIC for any year with respect to which a U.S. holder owns the ADSs, we will continue to be treated as a PFIC with respect to such U.S. holder in all succeeding years during which the U.S. holder owns the ADSs, regardless of whether we continue to meet the tests described above.

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Based on our past and current projections of our income and assets, we do not conclude that we were a PFIC for the taxable year ended December 31, 2022. A separate factual determination as to whether we are or have become a PFIC must be made each year (after the close of such year). For purposes of the PFIC asset test, the value of our assets will generally be determined by reference to our market capitalization. Since our projections may differ from our actual business results and our market capitalization and value of our assets may fluctuate substantially, we cannot assure you that we were not a PFIC for our taxable year ended December 31, 2022 and that we will not be or become a PFIC in the current taxable year or any future taxable year. Our status as a PFIC also depends on the interpretation of the rules governing the PFIC income and asset tests, which are subject to uncertainty (including with respect to the characterization of income from government grants, for which direct legal authority does not exist).

If we are a PFIC for any taxable year, then unless you make one of the elections described below, a special tax regime will apply to both (a) any "excess distribution" by us to you (generally, your ratable portion of distributions in any year which are greater than 125% of the average annual distribution received by you in the shorter of the three preceding years or your holding period for the ADSs) and (b) any gain realized on the sale or other disposition of the ADSs. Under this regime, any excess distribution and realized gain will be treated as ordinary income and will be subject to tax as if (a) the excess distribution or gain had been realized ratably over your holding period, (b) the amount deemed realized in each year had been subject to tax in each year of that holding period at the highest marginal rate for such year (other than income allocated to the current period or any taxable period before we became a PFIC, which would be subject to tax at the U.S. holder's regular ordinary income rate for the current year and would not be subject to the interest charge discussed below), and (c) the interest charge generally applicable to underpayments of tax had been imposed on the taxes deemed to have been payable in those years. In addition, dividend distributions made to you will not qualify for the lower rates of taxation applicable to long-term capital gains discussed above under "—Distributions."

Certain elections exist that would result in an alternative treatment (such as mark-to-market treatment) of the ADSs. If a U.S. holder makes the mark-to-market election, the U.S. holder generally will recognize as ordinary income any excess of the fair market value of the ADSs at the end of each taxable year over their adjusted tax basis, and will recognize an ordinary loss in respect of any excess of the adjusted tax basis of the ADSs over their fair market value at the end of the taxable year (but only to the extent of the net amount of income previously included as a result of the mark-to-market election). If a U.S. holder makes the election, the U.S. holder's tax basis in the ADSs will be adjusted to reflect these income or loss amounts. Any gain recognized on the sale or other disposition of ADSs in a year when we are a PFIC will be treated as ordinary income and any loss will be treated as an ordinary loss (but only to the extent of the net amount of income previously included as a result of the mark-to-market election). The mark-to-market election is available only if we are a PFIC and the ADSs are "regularly traded" on a "qualified exchange." The ADSs will be treated as "regularly traded" in any calendar year in which more than a *de minimis* quantity of the ADSs are traded on a qualified exchange on at least 15 days during each calendar quarter (subject to the rule that trades that have as one of their principal purposes the meeting of the trading requirement are disregarded). NASDAQ is a qualified exchange for this purpose and, consequently, if the ADSs are regularly traded, the mark- to-market election will be available to a U.S. holder if we are a PFIC.

If a U.S. holder makes an effective qualified electing fund election, or QEF Election, the U.S. holder will be required to include in gross income each year, whether or not we make distributions, as capital gains, such U.S. holder's pro rata share of our net capital gains and, as ordinary income, such U.S. holder's pro rata share of our earnings in excess of our net capital gains. However, a U.S. holder can only make a QEF Election with respect to ADSs of in a PFIC if such company agrees to furnish such U.S. holder with certain tax information annually. We do not intend to provide the information necessary for U.S. holders to make QEF Elections if we are treated as a PFIC for any taxable year.

If we are determined to be a PFIC for any taxable year included in the holding period of a U.S. holder, such holder may be subject to adverse tax consequences. U.S. holders should consult their tax advisors to determine whether any of these elections, or other elections for current or past taxable years, may be available and if so, what the consequences of the alternative treatments would be in their particular circumstances.

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If we are determined to be a PFIC, the general tax treatment for U.S. holders described in this section would apply to indirect distributions and gains deemed to be recognized by U.S. holders in respect of any of our subsidiaries that also may be determined to be PFICs.

If a U.S. holder owns ADSs during any taxable year in which we are a PFIC, the U.S. holder generally will be required to file an IRS Form 8621 (Information Return by a Shareholder of a Passive Foreign Investment Company or Qualified Electing Fund) with respect to us, generally with the U.S. holder's federal income tax return for that year. If our company were a PFIC for a given taxable year, then you should consult your tax advisor concerning your annual filing requirements.

**The U.S. federal income tax rules relating to PFICs are complex. Prospective U.S. investors are urged to consult their own tax advisors with respect to the acquisition, ownership and disposition of the ADSs, the consequences to them of an investment in a PFIC, any elections available with respect to the ADSs and the IRS information reporting obligations with respect to the acquisition, ownership and disposition of the ADSs.** 

*Backup Withholding and Information Reporting*. U.S. holders generally will be subject to information reporting requirements with respect to dividends on ADSs and on the proceeds from the sale, exchange or disposition of ADSs that are paid within the United States or through U.S.-related financial intermediaries, unless the U.S. holder is an "exempt recipient." In addition, U.S. holders may be subject to backup withholding on such payments, unless the U.S. holder provides a correct taxpayer identification number and a duly executed IRS Form W-9 or otherwise establishes an exemption. Backup withholding is not an additional tax, and the amount of any backup withholding will be allowed as a credit against a U.S. holder's U.S. federal income tax liability and may entitle such holder to a refund, provided that the required information is timely furnished to the IRS.

*Foreign Asset Reporting*. Certain U.S. holders who are individuals and certain entities controlled by individuals may be required to report information relating to an interest in the ADSs, subject to certain exceptions (including an exception for shares held in accounts maintained by U.S. financial institutions) by filing IRS Form 8938 (Statement of Specified Foreign Financial Assets) with their federal income tax return. U.S. holders are urged to consult their tax advisors regarding their information reporting obligations, if any, with respect to their acquisition, ownership and disposition of the ADSs.

**THE DISCUSSION ABOVE IS A GENERAL SUMMARY. IT DOES NOT COVER ALL TAX MATTERS THAT MAY BE OF IMPORTANCE TO A PROSPECTIVE INVESTOR. EACH PROSPECTIVE INVESTOR IS URGED TO CONSULT ITS OWN TAX ADVISOR ABOUT THE TAX CONSEQUENCES TO IT OF AN INVESTMENT IN ADSS IN LIGHT OF THE INVESTOR'S OWN CIRCUMSTANCES.** 

#### Belgian Tax Consequences
The following paragraphs are a summary of material Belgian tax consequences of the ownership of ADSs by an investor. The summary is based on laws, treaties and regulatory interpretations in effect in Belgium on the date of this Annual Report, all of which are subject to change, including changes that could have retroactive effect.

The summary only discusses Belgian tax aspects which are relevant to U.S. holders of ADSs (Holders). This summary does not address Belgian tax aspects which are relevant to persons who are fiscally resident in Belgium or who avail of a permanent establishment or a fixed base in Belgium to which the ADSs are effectively connected.

This summary does not purport to be a description of all of the tax consequences of the ownership of ADSs, and does not take into account the specific circumstances of any particular investor, some of which may be subject to special rules, or the tax laws of any country other than Belgium. This summary does not describe the tax treatment of investors that are subject to special rules, such as banks, insurance companies, collective investment undertakings, dealers in securities or currencies, persons that hold, or will hold, ADSs in a position in a straddle, share-repurchase transaction, conversion transactions, synthetic security or other integrated financial transactions. Investors should consult their own advisors regarding the tax consequences of an investment in ADSs in the light of their particular circumstances, including the effect of any state, local or other national laws.

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In addition to the assumptions mentioned above, it is also assumed in this discussion that for purposes of the domestic Belgian tax legislation, the owners of ADSs will be treated as the owners of the ordinary shares represented by such ADSs. However, the assumption has not been confirmed by or verified with the Belgian Tax Authorities.

#### Dividend Withholding Tax
As a general rule, a withholding tax of 30% is levied on the gross amount of dividends paid on the ordinary shares represented by the ADSs, subject to such relief as may be available under applicable domestic or tax treaty provisions.

Dividends subject to the dividend withholding tax include all benefits attributed to the ordinary shares represented by the ADSs, irrespective of their form, as well as reimbursements of statutory share capital by us, except reimbursements of fiscal capital made in accordance with the Belgian Companies Code. In principle, fiscal capital includes paid-up statutory share capital, and subject to certain conditions, the paid-up issue premiums and the amounts subscribed to at the time of the issue of profit-sharing certificates. As a rule, any reduction of fiscal capital is deemed to be paid out on a *pro rata* basis of the fiscal capital and certain reserves (in the following order: the taxed reserves incorporated in the statutory capital, the taxed reserves not incorporated in the statutory capital and the tax-exempt reserves incorporated in the statutory capital). Only the part of the capital reduction that is deemed to be paid out of the fiscal capital will, for Belgian withholding tax purposes, not be considered as a dividend distribution provided such repayment is carried out in accordance with the relevant provisions of company law.

In case of a redemption by us of our own shares represented by ADSs, the redemption distribution (after deduction of the portion of fiscal capital represented by the redeemed shares) will be treated as a dividend which in principle is subject to the withholding tax of 30%, subject to such relief as may be available under applicable domestic or tax treaty provisions. In case of a liquidation of our company, any amounts distributed in excess of the fiscal capital will also be treated as a dividend, and will in principle be subject to a 30% withholding tax, subject to such relief as may be available under applicable domestic or tax treaty provisions.

For non-residents the dividend withholding tax, if any, will be the only tax on dividends in Belgium, unless the non-resident avails of a fixed base in Belgium or a Belgian permanent establishment to which the ADSs are effectively connected.

#### Relief of Belgian Dividend Withholding Tax
Under the U.S.-Belgium Tax Treaty, under which we are entitled to benefits accorded to residents of Belgium, there is a reduced Belgian withholding tax rate of 15% on dividends paid by us to a U.S. resident which beneficially owns the dividends and is entitled to claim the benefits of the U.S.-Belgium Tax Treaty under the limitation of benefits article included in the U.S.-Belgium Tax Treaty (Qualifying Holders).

If such Qualifying Holder is a company that owns directly at least 10% of our voting stock, the Belgian withholding tax rate is further reduced to 5%. No withholding tax is however applicable if the Qualifying Holder, is either of the following:

• A company that is a resident of the United States that has owned directly ADSs representing at least 10% of our capital for a twelve-month period ending on the date the dividend is declared, or

• A pension fund that is a resident of the United States, provided that such dividends are not derived from the carrying on of a business by the pension fund or through an associated enterprise.

Under the normal procedure, we or our paying agent must withhold the full Belgian withholding tax, without taking into account the reduced U.S.-Belgium Tax Treaty rate. Qualifying Holders may then make a claim for reimbursement for amounts withheld in excess of the rate defined by the U.S.-Belgium Tax Treaty. The reimbursement form (Form 276 Div-Aut.) can be obtained as follows:

• By letter from the Bureau Central de Taxation Bruxelles-Etranger, Boulevard du Jardin Botanique 50 boîte 3429, 1000 Brussels, Belgium;

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• By fax at +32 (0) 257/968 42;

• Via e-mail at ctk.db.brussel.buitenland@minfin.fed.be; or at

• *Http://financien.belgium.be/nl/ondernemingen/vennootschapsbelasting/voorheffingen/roerende_voorheffing/formulieren*.

The reimbursement form is to be sent to the Bureau Central de Taxation Bruxelles-Etranger, Boulevard du Jardin Botanique 50 boîte 3429, 1000 Brussels, Belgium as soon as possible and in each case within a term of five years starting from the first of January of the year the withholding tax was withheld.

Qualifying Holders may also, subject to certain conditions, obtain the reduced U.S.-Belgium Tax Treaty rate at source. Qualifying Holders should deliver a duly completed Form 276 Div-Aut. no later than ten days after the date on which the dividend has been paid or attributed (whichever comes first).

Additionally, pursuant to Belgian domestic tax law, dividends distributed to corporate Holders that qualify as a parent company will be exempt from Belgian withholding tax provided that the ADSs held by the Holder, upon payment or attribution of the dividends, amount to at least 10% of our share capital and are held or will be held during an uninterrupted period of at least one year, and provided the anti-abuse provision does not apply. A Holder qualifies as a parent company if it has a legal form similar to the ones listed in the annex to the EU Parent-Subsidiary Directive of 23 July 1990 (90/435/EC), if it is considered to be a tax resident according to the laws of the United States and the U.S.-Belgium Tax Treaty, and if it is subject to a tax similar to the Belgian corporate income tax without benefiting from a tax regime that derogates from the ordinary tax regime.

In order to benefit from this exemption, the Holder must provide us or our paying agent with a certificate confirming its qualifying status and the fact that it satisfies the required conditions. If the Holder holds the ADSs for less than one year, at the time the dividends are paid on or attributed to the shares represented by the ADSs, we must deducts the withholding tax but we do not need to transfer it to the Belgian Treasury provided that the Holder certifies its qualifying status, the date from which the Holder has held the ADSs, and the Holder's commitment to hold the shares for an uninterrupted period of at least one year. The Holder must also inform us or our paying agent when the one-year period has expired or if its shareholding drops below 10% of our share capital before the end of the one-year holding period. Upon satisfying the one-year shareholding requirement, the deducted dividend withholding tax will be paid to the Holder.

Dividends paid or attributable to a corporate Holder will under certain conditions benefit from a full withholding tax exemption, provided that the Holder has a legal form similar to the ones listed in in Annex I, Part A to Council Directive 2011/96/EU of November 30, 2011 on the common system of taxation applicable in the case of parent companies and subsidiaries of different Member States, as amended by the Council Directive of July 8, 2014 (2014/86/EU) and holds a share participation in our share capital, upon payment or attribution of the dividends, of less than 10% but with an acquisition value of at least EUR 2,500,000 and has held this share participation in full legal ownership during an uninterrupted period of at least one year. The Holder should also be subject to corporate income tax or a similar tax without benefiting from a tax regime that derogates from the ordinary tax regime.

The Holder must provide us or our paying agent with a certificate confirming its qualifying status and the fact that it meets the required conditions.

Withholding tax is also not applicable, pursuant to Belgian domestic tax law, on dividends paid to a U.S. pension fund which satisfies the following conditions:

(i) To be an entity with a separate legal personality with fiscal residence in the United States and without a permanent establishment or fixed base in Belgium,

(ii) Whose corporate purpose consists solely in managing and investing funds collected in order to pay legal or complementary pensions,

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(iii) Whose activity is limited to the investment of funds collected in the exercise of its statutory mission, without any profit-making aim and without operating a business in Belgium,

(iv) Which is exempt from income tax in the United States, and

(v) Provided that it (save in certain particular cases as described in Belgian law) is not contractually obligated to redistribute the dividends to any ultimate beneficiary of such dividends for whom it would manage the shares or ADSs, nor obligated to pay a manufactured dividend with respect to the shares or ADSs under a securities borrowing transaction. The exemption will only apply if the U.S. pension fund provides an affidavit confirming that it is the full legal owner or usufruct holder of the shares or ADSs and that the above conditions are satisfied. The organization must then forward that affidavit to us or our paying agent.

Non-resident individuals may be eligible for an exemption of the first tranche of dividend income up to the amount of €800 for the 2020 taxable year for dividends paid or attributed as of January 1, 2019. Prospective Holders are encouraged to consult their own tax advisors to determine whether they qualify for an exemption or a reduction of the withholding tax rate upon payment of dividends and, if so, the procedural requirements for obtaining such an exemption or a reduction upon the payment of dividends or making claims for reimbursement.

#### Capital Gains and Losses
Pursuant to the U.S.-Belgium Tax Treaty, capital gains and/or losses realized by a Qualifying Holder from the sale, exchange or other disposition of ADSs are exempt from tax in Belgium.

Capital gains realized on ADSs by a corporate Holder who is not a Qualifying Holder are generally not subject to taxation in Belgium unless such Holder is acting through a Belgian permanent establishment or a fixed place in Belgium to which the ADSs are effectively connected (in which case a 25% or 0% tax on the capital gain may apply, depending on the particular circumstances, taking into account that different rates may apply if the establishment qualifies as a small enterprise). Capital losses are generally not tax deductible.

Private individual Holders who are not Qualifying Holders and who are holding ADSs as a private investment will, as a rule, not be subject to tax in Belgium on any capital gains arising out of a disposal of ADSs. Losses will, as a rule, not be tax deductible.

However, if the gain realized by such individual Holders on ADSs is deemed to be realized outside the scope of the normal management of such individual's private estate and the capital gain is obtained or received in Belgium, the gain will be subject to a final tax of 33%.

Moreover, capital gains realized by such individual Holders on the disposal of ADSs for consideration, outside the exercise of a professional activity, to a non-resident corporation (or a body constituted in a similar legal form), to a foreign state (or one of its political subdivisions or local authorities) or to a non-resident legal entity that is established outside the European Economic Area, are in principle taxable at a rate of 16.5% if, at any time during the five years preceding the realization event, such individual Holders own or have owned directly or indirectly, alone or with his/her spouse or with certain other relatives, a substantial shareholding in us (that is, a shareholding of more than 25% of our shares).

Capital gains realized by a Holder upon the redemption of ADSs or upon our liquidation will generally be taxable as a dividend. See "—Dividend Withholding Tax" above.

#### Estate and Gift Tax
There is no Belgium estate tax on the transfer of ADSs on the death of a Belgian non-resident. Donations of ADSs made in Belgium may or may not be subject to gift tax depending on the modalities under which the donation is carried out.

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#### Belgian Tax on Stock Exchange Transactions
A stock market tax is normally levied on the purchase and the sale and on any other acquisition and transfer for consideration in Belgium of ADSs through a professional intermediary established in Belgium on the secondary market, so-called "secondary market transactions." The tax is due from the transferor and the transferee separately. The applicable rate amounts to 0.35% with a cap of €1600 per transaction and per party. Such tax is also due for transactions the order for which is directly or indirectly given by an individual with habitual abode in Belgium, or by a legal entity on account of its Belgian seat or establishment, to an intermediary established outside Belgium. In such case, this individual or legal entity should declare and pay the tax on stock exchange transactions due, unless if he can prove that it was already paid.

Belgian non-residents who purchase or otherwise acquire or transfer, for consideration, ADSs in Belgium for their own account through a professional intermediary may be exempt from the stock market tax if they deliver a sworn affidavit to the intermediary in Belgium confirming their non-resident status, unless they would be considered to have their habitual abode (for individuals) or their seat or establishment (for legal entities) in Belgium. Intermediaries located or established outside of Belgium may appoint a Stock Exchange Tax Representative in Belgium, subject to certain conditions and formalities.

In addition to the above, no stock market tax is payable by: (i) professional intermediaries described in Article 2, 9 and 10 of the Law of August 2, 2002 acting for their own account, (ii) insurance companies described in Article 2, §1 of the Law of July 9, 1975 acting for their own account, (iii) professional retirement institutions referred to in Article 2, §1 of the Law of October 27, 2006 relating to the control of professional retirement institutions acting for their own account, (iv) collective investment institutions acting for their own account, (v) the aforementioned non-residents acting for their own account (upon delivery of a certificate of non-residency in Belgium), or (vi) regulated real estate companies acting for their own account.

No stock market tax will thus be due by Holders on the subscription, purchase or sale of ADSs, if the Holders are acting for their own account. In order to benefit from this exemption, the Holders must file with the professional intermediary in Belgium a sworn affidavit evidencing that they are non-residents for Belgian tax purposes.

#### Proposed Financial Transactions Tax
The European Commission has published a proposal for a Directive for a common financial transactions tax, or FTT, in Belgium, Germany, Estonia, Greece, Spain, France, Italy, Austria, Portugal, Slovenia and Slovakia, or collectively, the Participating Member States. However, Estonia has since stated that it will not participate, and it is unclear whether Belgium will participate.

The proposed FTT has a very broad scope and could, if introduced in its current form, apply to certain dealings in ADSs in certain circumstances. Under current proposals, the FTT could apply in certain circumstances to persons both within and outside of the Participating Member States. Generally, it would apply to certain dealings in ADSs where at least one party is a financial institution, and at least one party is established in a Participating Member State.

A financial institution may be, or be deemed to be, ''established'' in a Participating Member State in a broad range of circumstances, including by transacting with a person established in a Participating Member State.

The proposal currently stipulates that once the FTT enters into force, the participating Member States shall not maintain or introduce taxes on financial transactions other than the FTT (or VAT as provided in the Council Directive 2006/112/EC on the common system of value added tax). For Belgium, the tax on stock exchange transactions should thus be abolished once the FTT enters into force. The proposal is still subject to negotiation between the participating Member States and therefore may be changed at any time.

Prospective investors are advised to seek their own professional advice in relation to the FTT.

#### Prospective Tax on Securities Accounts
Belgium also applies a prospective tax on securities accounts of 0.15% on the average value of certain qualifying financial instruments held in one or more securities accounts during a reference period of 12 consecutive months. Prospective Holders are encouraged to consult their own tax advisors to determine the applicability and extent of such tax with respect to their ADSs.

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F. Dividends and Paying Agents

Not applicable.

G. Statement by Experts

Not applicable.

H. Documents on Display

We are subject to the information reporting requirements of the Exchange Act applicable to foreign private issuers and under those requirements will file reports with the SEC. Those reports may be inspected without charge on the websites described below. As a foreign private issuer, we are exempt from the rules under the Exchange Act related to the furnishing and content of proxy statements, and our officers, directors and principal shareholders are exempt from the reporting and short-swing profit recovery provisions contained in Section 16 of the Exchange Act. In addition, we are not required under the Exchange Act to file periodic reports and financial statements with the SEC as frequently or as promptly as United States companies whose securities are registered under the Exchange Act. Nevertheless, we will file with the SEC an Annual Report on Form 20-F containing financial statements that have been examined and reported on, with and opinion expressed by an independent registered public accounting firm.

We maintain a corporate website at *www.celyad.com*. We intend to post our Annual Report on our website promptly following it being filed with the SEC. Information contained on, or that can be accessed through, our website does not constitute a part of this Annual Report. We have included our website address in this Annual Report solely as an inactive textual reference.

The SEC maintains a website (*www.sec.gov*) that contains reports, proxy and information statements and other information regarding registrants, such as Celyad, that file electronically with the SEC.

With respect to references made in this Annual Report to any contract or other document relating to Celyad, such references are not necessarily complete, and you should refer to the exhibits attached or incorporated by reference to this Annual Report for copies of the actual contract or document.

I. Subsidiary Information

Not applicable.

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|:---|:---|
| **ITEM 11.** | **QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK**  |

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We are exposed to a variety of financial risks: market risk (including foreign exchange risk and interest rate risk), credit risk and liquidity risk. Our overall risk management program focuses on preservation of capital given the unpredictability of financial markets. For additional information on general risk factors, please see the section of this Annual Report titled "Item 3.D—Risk Factors."

#### Interest rate risk
Our interest rate risk is very limited as we have only a limited amount of finance leases and outstanding bank loans. So far, because of the immateriality of the exposure, we did not enter into any interest hedging arrangements.

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#### Credit risk
We have a limited amount of trade receivables due to the fact that sales to third parties are not significant, and thus our credit risk arises mainly from cash and cash equivalents and deposits with banks and financial institutions. We only work with international reputable commercial banks and financial institutions.

#### Foreign Exchange Risk
We are exposed to foreign exchange risk as certain collaborations or supply agreements of raw materials are denominated in USD. Moreover, we also have investments in foreign operations, whose net assets are exposed to foreign currency translation risk (USD). So far, because of the immateriality of the exposure, we did not enter into any currency hedging arrangements. Sensitivity analysis has been performed on the foreign exchange risk, we refer to Note 4, and we still consider this risk as immaterial.

We are exposed to foreign exchange risk arising from various currency exposures, primarily with respect to the USD. Our functional currency is the Euro, but several of our product suppliers and clinical vendors invoice us in USD or in other currencies.

We have not established any formal practice to manage the foreign exchange risk against our functional currency. As of December 31, 2022, we have trade receivables denominated in USD of $0.2 million and had trade payables denominated in USD of $1.4 million.

For the year ended December 31, 2021, we recorded an unrealized foreign exchange gain of €0.01 million arising mainly from our cash and short-term deposits denominated in USD. For the year ended December 31, 2022, we recorded an unrealized foreign exchange gain of €0.2 million arising mainly from our cash and short-term deposits denominated in USD. Foreign exchange rate movements had no material effect on our results for the year ended December 31, 2022. Because of our future potential activities in the United States, our foreign exchange risk may increase in the future.

In 2022, 19.6%, or $5.9 million, of our total costs were expressed in USD. In the same period for 2021 and 2020, our costs expressed in USD were 24.1%, or $10.4 million, and 17.5%, or $6.2 million, respectively. In 2022 and beyond, we expect the proportion of costs expressed in USD will decrease due to decision to discontinue the clinical studies.

#### Liquidity Risk
We are pursuing a strategy to develop products and platforms that will help our partners to treat medical needs in oncology. Management has prepared detailed budgets and cash flow forecasts for the years 2023 and 2024. These forecasts reflect the new strategy of the Group and include significant expenses and cash outflows estimations in relation to the development of its proprietary technology platforms and intellectual property, partly compensated by grants funding and tax incentives. In performing this assessment, management considered factors that could indicate the presence of material uncertainties that may cast significant doubt upon our ability to continue as a going concern. Factors, among others, considered included: operating losses and absence of any firm commitments for additional financing before the reporting date.

As of December 31, 2022, we had cash and cash equivalents of €12.4 million and no short-term investments. We project that our existing cash and cash equivalents should be sufficient to fund operating expenses and capital expenditure requirements into the fourth quarter of 2023.

After due consideration of detailed budgets and estimated cash flow forecasts for the years 2023 and 2024, we project that our existing cash and cash equivalents will not be sufficient to fund its estimated operating and capital expenditures over at least the next 12 months from the date that the financial statements are issued.

We are currently evaluating different financing options to obtain the required funding to extend our cash runway beyond 12 months from the date the financial statements are issued. Financing options may include, but are not limited to, the public or private sale of equity, debt financings or funds from other capital sources, such as collaborations, strategic alliances and partnerships, or licensing arrangements with third parties. However, there can be no assurance that we will be able to secure additional financing, or if available, that it will be sufficient to meet our needs or available on favorable terms indicating a material uncertainty exists about our ability to continue as a going concern.

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After due consideration of the above, the Board of Directors determined that Management has an appropriate basis to conclude on the business continuity over the next 12 months from the date the financial statements are issued, and hence it is appropriate to prepare the financial statements on a going concern basis.

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| **ITEM 12.** | **DESCRIPTION OF SECURITIES OTHER THAN EQUITY SECURITIES**  |

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A. Debt Securities

Not applicable.

B. Warrants and Rights

Not applicable.

C. Other Securities

Not applicable.

D. American Depositary Shares

Citibank, N.A. is the depositary for our American Depositary Shares. Citibank's depositary offices are located at 388 Greenwich Street, New York, New York 10013. American Depositary Shares are frequently referred to as "ADSs" and represent ownership interests in securities that are on deposit with the depositary. ADSs may be represented by certificates that are commonly known as "American Depositary Receipts" or "ADRs." The depositary typically appoints a custodian to safekeep the securities on deposit. In this case, the custodian is Citibank Europe plc, located at EGSP 186, 1 North Wall Quay, Dublin 1 Ireland.

We have appointed Citibank as depositary pursuant to a deposit agreement. A copy of the deposit agreement is on file with the SEC under cover of a Registration Statement on Form F-6 (File No. 333-204724).

#### Fees and Charges
Pursuant to the terms of the deposit agreement, the holders of ADSs will be required to pay the following fees:

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|:---|:---|
| **Service** | **Fees** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Issuance of ADSs upon deposit of shares (excluding issuances as a result of distributions of shares) | Up to U.S. 5¢ per ADS issued |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Cancellation of ADSs | Up to U.S. 5¢ per ADS canceled |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Distribution of cash dividends or other cash distributions (i.e., sale of rights and other entitlements) | Up to U.S. 5¢ per ADS held |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Distribution of ADSs pursuant to (i) stock dividends or other free stock distributions, or (ii) exercise of rights to purchase additional ADSs | Up to U.S. 5¢ per ADS held |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Distribution of securities other than ADSs or rights to purchase additional ADSs (i.e., spin-off shares) | Up to U.S. 5¢ per ADS held |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• ADS Services | Up to U.S. 5¢ per ADS held on the applicable record date(s) established by the depositary |

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As an ADS holder, you will also be responsible to pay certain charges such as:

• Taxes (including applicable interest and penalties) and other governmental charges;

• The registration fees as may from time to time be in effect for the registration of ordinary shares on the share register and applicable to transfers of ordinary shares to or from the name of the custodian, the depositary or any nominees upon the making of deposits and withdrawals, respectively;

• Certain cable, telex and facsimile transmission and delivery expenses;

• The expenses and charges incurred by the depositary in the conversion of foreign currency;

• The fees and expenses incurred by the depositary in connection with compliance with exchange control regulations and other regulatory requirements applicable to ordinary shares, ADSs and ADRs; and

• The fees and expenses incurred by the depositary, the custodian, or any nominee in connection with the servicing or delivery of deposited property.

ADS fees and charges payable upon (i) deposit of ordinary shares against issuance of ADSs and (ii) surrender of ADSs for cancellation and withdrawal of ordinary shares are charged to the person to whom the ADSs are delivered (in the case of ADS issuances) and to the person who delivers the ADSs for cancellation (in the case of ADS cancellations). In the case of ADSs issued by the depositary into DTC or presented to the depositary via DTC, the ADS issuance and cancellation fees and charges may be deducted from distributions made through DTC, and may be charged to the DTC participant(s) receiving the ADSs or the DTC participant(s) surrendering the ADSs for cancellation, as the case may be, on behalf of the beneficial owner(s) and will be charged by the DTC participant(s) to the account(s) of the applicable beneficial owner(s) in accordance with the procedures and practices of the DTC participant(s) as in effect at the time. ADS fees and charges in respect of distributions and the ADS service fee are charged to the holders as of the applicable ADS record date. In the case of distributions of cash, the amount of the applicable ADS fees and charges is deducted from the funds being distributed. In the case of (i) distributions other than cash and (ii) the ADS service fee, holders as of the ADS record date will be invoiced for the amount of the ADS fees and charges and such ADS fees and charges may be deducted from distributions made to holders of ADSs. For ADSs held through DTC, the ADS fees and charges for distributions other than cash and the ADS service fee may be deducted from distributions made through DTC, and may be charged to the DTC participants in accordance with the procedures and practices prescribed by DTC and the DTC participants in turn charge the amount of such ADS fees and charges to the beneficial owners for whom they hold ADSs.

In the event of refusal to pay the depositary fees, the depositary may, under the terms of the deposit agreement, refuse the requested service until payment is received or may set off the amount of the depositary fees from any distribution to be made to the ADS holder. Note that the fees and charges you may be required to pay may vary over time and may be changed by us and by the depositary. You will receive prior notice of such changes. The depositary may reimburse us for certain expenses incurred by us in respect of the ADR program, by making available a portion of the ADS fees charged in respect of the ADR program or otherwise, upon such terms and conditions as we and the depositary agree from time to time.

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PART II

The deposit agreement and the ADSs will be interpreted in accordance with the laws of the State of New York. The rights of holders of ordinary shares (including ordinary shares represented by ADSs) are governed by the laws of Belgium.

ITEM 13. Defaults, Dividend Arrearages And Delinquencies

Not applicable.

ITEM 14. MATERIAL MODIFICATIONS TO THE RIGHTS OF SECURITY HOLDERS AND USE OF PROCEEDS

Not applicable.

ITEM 15. CONTROLS AND PROCEDURES

Evaluation of Disclosure Controls and Procedures

We maintain disclosure controls and procedures as such term is defined in Rules 13(a)-15(e) and 15(d)-15(e) under the Securities Exchange Act of 1934, as amended, or the Exchange Act, that are designed to ensure that information required to be disclosed in the reports that we file or submits under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the rules and forms of the Securities and Exchange Commission. Disclosure controls and procedures include, without limitation, controls and procedures designed to ensure that information required to be disclosed in our reports filed or submitted under the Exchange Act is accumulated and communicated to management, including our Interim Chief Executive Officer and Vice President of Finance and Administration, as appropriate, to allow timely decisions regarding required disclosure. Disclosure controls and procedures, no matter how well designed and operated, can only provide reasonable assurance of achieving the desired control objectives.

Our Interim Chief Executive Officer (principal executive officer) and Vice President of Finance and Administration (principal financial officer) has carried out an evaluation of the effectiveness of our disclosure controls and procedures as of December 31, 2022. Based on that evaluation, our Interim Chief Executive Officer (principal executive officer) and Vice President of Finance and Administration (principal financial officer) concluded that our disclosure controls and procedures were effective as of December 31, 2022.

Management's Annual Report on Internal Control over Financial Reporting

Our management is responsible for establishing and maintaining adequate internal control over financial reporting, as such term is defined in Exchange Act Rules 13a-15(f) and 15d-15(f). Internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external reporting purposes in accordance with generally accepted accounting principles.

Under the supervision and with the participation of our management, including our Interim Chief Executive Officer (principal executive officer) and Vice President of Finance and Administration (principal financial officer), we conducted an evaluation of the effectiveness of our internal control over financial reporting as of December 31, 2022 based on the guidelines established in Internal Control-Integrated Framework (2013) issued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO).

A material weakness is a deficiency, or combination of deficiencies, in internal control over financial reporting, such that there is a reasonable possibility that a material misstatement of our annual or interim financial statements will not be prevented or detected on a timely basis.

The uncertainties raised by the COVID-19 pandemic and war in Ukraine are not impacting our internal control framework reporting (ICFR). For additional information on COVID-19 pandemic and war in Ukraine updates, refer to note 2 of our financial statements.

Management identified no material weakness as of December 31, 2022. As a result, we have concluded that our internal control over financial reporting was effective as of December 31, 2022.

Our management, including our Interim Chief Executive Officer (principal executive officer) and Vice President of Finance and Administration (principal financial officer), believes that the consolidated financial statements contained in this Annual Report present fairly, in all material respects, our financial position, results of operations and cash flows for the periods presented in conformity with IFRS.

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Management's Plan for Remediation

Not applicable.

Attestation Report of the Registered Public Accounting Firm

Not applicable.

Changes in Internal Control Over Financial Reporting

Not applicable.

Limitations on Effectiveness of Controls and Procedures

Our management, including our Interim Chief Executive Officer (principal executive officer) and Vice President of Finance and Administration (principal financial officer), does not expect that our disclosure controls and procedures or our internal control over financial reporting will provide absolute assurance that all appropriate information will, in fact, be communicated to management to allow timely decisions to be made or prevent all error and fraud. A control system, no matter how well conceived and operated, can provide only reasonable, not absolute, assurance that the objectives of the control system are met. Additionally, the design of a control system must reflect the fact that there are resource constraints, and the benefit of controls must be considered relative to their costs. Because of the inherent limitations in all control systems, no evaluation of controls can provide absolute assurance that all control issues and instances of fraud, if any, within us, have been detected or that our control system will operate effectively under all circumstances. Moreover, the design of any system of controls is based in part upon certain assumptions about the likelihood of future events, and there can be no assurance that any design will succeed in achieving its stated goals under all potential future conditions.

ITEM 16. RESERVED

ITEM 16A. AUDIT COMMITTEE FINANCIAL EXPERT

Audit Committee

Our Board of Directors has determined that Dominic Piscitelli is an Audit Committee financial expert as defined by SEC rules and has the requisite financial sophistication under the applicable rules and regulations of the Nasdaq Stock Market. Dominic Piscitelli is independent as such term is defined in Rule 10A-3 under the Exchange Act and under the listing standards of the Nasdaq Stock Market.

ITEM 16B. CODE OF ETHICS

In 2015, we adopted a Code of Business Conduct and Ethics, or the Code of Conduct, that is applicable to all of our employees, members of our Executive Committee and our directors. It was most recently updated on June 25, 2020. The Code of Conduct is on our website at https://www.celyad.com/en/investors/corporate-governance. The Audit Committee of our Board of Directors is responsible for overseeing the Code of Conduct and is required to approve any waivers of the Code of Conduct for employees, members of our Executive Committee or our directors.

ITEM 16C. PRINCIPAL ACCOUNTANT FEES AND SERVICES

Our independent public accounting firm is EY Réviseurs d'Entreprises / EY Bedrijfsrevisoren SRL/BV, Diegem, Belgium, PCAOB Auditor ID 1467.

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EY Réviseurs d'Entreprises / EY Bedrijfsrevisoren SRL/BV or EY has been our Auditor since May 5, 2020, as decided by our shareholders at the Annual General Assembly. Hereunder the fees billed by our Auditors for the last two years:

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| | | |
|:---|:---|:---|
| (€'000) | Year Ended December 31, | Year Ended December 31, |
|  | 2022 | 2021 |
| Audit fees | 277 | 327 |
| Audit-related fees | 5 | 12 |
| Tax fees | 2 | 5 |
| Other fees | 7 |  |
| Total | 292 | 344 |

---

"Audit Fees" are the aggregate fees billed for the audit of our annual financial statements. This category also includes services that generally the independent accountant provides, such as consents and assistance with and review of documents filed with the SEC.

"Audit-Related Fees" are the aggregate fees billed for assurance and related services that are reasonably related to the performance of the audit and are not reported under Audit Fees.

"Tax Fees" are the aggregate fees billed for professional services rendered by the principal accountant for tax compliance, tax advice and tax planning related services.

"Other Fees" are any additional amounts billed for products and services provided by the principal accountant.

Audit and Non-Audit Services Pre-Approval Policy

The Audit Committee has responsibility for, among other things, appointing, setting compensation of and overseeing the work of our independent registered public accounting firm. In recognition of this responsibility, the Audit Committee has adopted a policy governing the pre-approval of all audit and permitted non-audit services performed by our independent registered public accounting firm to ensure that the provision of such services does not impair the independent registered public accounting firm's independence from us and our management. Unless a type of service to be provided by our independent registered public accounting firm has received general pre-approval from the Audit Committee, it requires specific pre-approval by the Audit Committee. The payment for any proposed services in excess of pre-approved cost levels requires specific pre-approval by the Audit Committee.

Pursuant to its pre-approval policy, the Audit Committee may delegate its authority to pre-approve services to the chairperson of the Audit Committee. The decisions of the chairperson to grant pre-approvals must be presented to the full Audit Committee at its next scheduled meeting. The Audit Committee may not delegate its responsibilities to pre-approve services to the management.

EY Réviseurs d'Entreprises / EY Bedrijfsrevisoren SRL/BV or EY has served as our independent registered public accounting firm since May 2020. Audit fees with respect to 2022 amounted to €277,058. Audit fees are the aggregate fees billed for the audit of our annual financial statements. This category also includes services that EY generally provides, such as consents, comfort letters, reports in accordance with Belgian Company Law and assistance with and review of documents filed with the SEC.

The audit-related fees paid to EY amounted to €4,500 in 2022. The tax fees paid to EY amounted to €1,750 (related to FY2021 tax return and routine on-call tax services) in 2022. Other fees were paid to EY amounted to €7,000 in 2022. All of the services (100%) paid to EY in 2022 have been pre-approved by the Audit Committee and in accordance with Regulation S-X, Rule 2-01, paragraph (c)(7)(i), no fees for professional services were approved pursuant to any waivers of the pre-approval requirement.

ITEM 16D. EXEMPTIONS FROM THE LISTING STANDARDS FOR AUDIT COMMITTEES

Not applicable.

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ITEM 16E. PURCHASES OF EQUITY SECURITIES BY THE ISSUER AND AFFILIATED PURCHASERS

Not applicable.

ITEM 16F. CHANGE IN REGISTRANT'S CERTIFYING ACCOUNTANT

I

n accordance with Belgian Company Law, EY Réviseurs d'Entreprises / EY Bedrijfsrevisoren SRL/BV was appointed to act as our independent registered accounting firm to audit our consolidated financial statements for the fiscal years ending December 31, 2022, 2021 and 2020. This audit mandate will expire in 2023, upon completion of the audit for the period ending December 31, 2022.

In 2023, we invited auditing firms to submit engagement proposals for their services for the next three-year period, covering the years ending December 31, 2023, 2024 and 2025.

On March 10, 2023, our Audit Committee approved the recommendation to our general shareholders meeting of the engagement of BDO Réviseurs d'Entreprises SRL to act as our independent registered public accounting firm for our financial periods beginning as of January 1, 2023. As a result, following completion of the audit of our financial statements as of and for the year ended December 31, 2022, BDO Réviseurs d'Entreprises SRL will become our independent registered accounting firm, subject to approval by shareholders at our general shareholders meeting scheduled for May 5, 2023.

EY Réviseurs d'Entreprises / EY Bedrijfsrevisoren SRL/BV's reports on our consolidated financial statements for the three-year period ended December 31, 2022 did not contain an adverse opinion or disclaimer of opinion or report, nor was any report qualified or modified as to audit scope or accounting principles, except for an explanatory paragraph in their December 31, 2022 audit opinion relating to our ability to continue as a going concern.

During our two most recent fiscal years, there were no "disagreements" (as that term is described in Item 16F.(a)(1)(iv) of the Instructions to Item 16F.) with EY Réviseurs d'Entreprises / EY Bedrijfsrevisoren SRL/BV, whether or not resolved, on any matter of accounting principles or practices, financial statement disclosure, or auditing scope or procedures, which disagreement, if not resolved to the satisfaction of EY Réviseurs d'Entreprises / EY Bedrijfsrevisoren SRL/BV, would have caused EY Réviseurs d'Entreprises / EY Bedrijfsrevisoren SRL/BV to make a reference to the subject matter of the disagreement in connection with any reports it would have issued.

During our two most recent fiscal years, there were no "reportable events" (as that term is described in Item 16F.(a)(1)(v) of the Instructions to Item 16F.)

We have provided EY Réviseurs d'Entreprises / EY Bedrijfsrevisoren SRL/BV with a copy of the foregoing disclosure, and we have requested that it furnish us with a letter addressed to the SEC stating whether or not it agrees with the above disclosures. A copy of this letter is filed as Exhibit 16.1 to this Form 20-F.

We did not consult BDO Réviseurs d'Entreprises SRL during our three most recent fiscal years or any subsequent interim period regarding (i) the application of accounting principles to a specified transaction, either completed or proposed or the type of audit opinion that might be rendered on our financial statements; or (ii) any matter that was the subject of a disagreement as that term is used in Item 16F(a)(1)(iv) of Form 20-F or a reportable event as described in Item 16F(a)(1)(v) of Form 20-F.

ITEM 16G. CORPORATE GOVERNANCE

Along with our articles of association, we adopted a corporate governance charter in accordance with the recommendations set out in the Belgian Corporate Governance Code 2020, or the CGC, issued on May 9, 2019, by the Belgian Corporate Governance Committee. The CGC is based on a "comply or explain" system; Belgian listed companies are expected to follow the CGC but can deviate from specific provisions and guidelines (though not the principles) provided they disclose the justification for such deviations.

Our Board of Directors complies with the principles of the CGC. However, we deviate from the following principles:

• Remuneration in company's shares (principle 7.6) : as per applicable laws, we do not meet the legal requirements to proceed with a shares buy-back and, consequently does not own treasury shares, and therefore, is not able to grant a portion of non-executive directors' remuneration in company's shares;

• No grant of stock options to independent directors (principle 7.6): since we are not able to offer treasury shares, independent directors may be allocated a fixed number of subscription rights (warrants). This allocation of warrants is not related to any performance criteria. As further detailed in our Remuneration Policy, this allocation is aimed at attracting highly skilled non-executive directors in a highly dynamic and competitive market;

• Absence of minimum detention of shares (principle 7.9): at the date of this Report, we have not fixed any minimum threshold for the detention of shares by the members of the Executive Committee. However, the members of the Executive Committee hold subscription rights (warrants) on the Company's shares as described in the Remuneration Report;

• No clawback (principle 7.12): at the date of this report, we have not adopted any clawback provision to claim variable remuneration from the Executive Committee members.

In accordance with the CGC, our Board of Directors will review its Charter from time to time and make such changes as it deems necessary and appropriate. The Charter, together with our articles of association, is available on our website (www.celyad.com) and can be obtained free of charge at our registered office. The Charter was most recently updated by resolutions of our Board of Directors on November 28, 2019.

Differences between Our Corporate Governance Practices and the Listing Rules of the NASDAQ Stock Market

The listing rules of the NASDAQ Stock Market include certain accommodations in the corporate governance requirements that allow foreign private issuers, to follow "home country" corporate governance practices in lieu of the otherwise applicable corporate governance standards of the NASDAQ Stock Market. The application of such exceptions requires that we disclose each noncompliance with the NASDAQ Stock Market listing rules that we do not follow and describe the Belgian corporate governance practices we do follow in lieu of the relevant NASDAQ Stock Market corporate governance standard.

We intend to continue to follow Belgian corporate governance practices in lieu of the corporate governance requirements of the NASDAQ Stock Market in respect of the following:

• Quorum at Shareholder Meetings . NASDAQ Stock Market Listing Rule 5620(c) requires that for any meeting of shareholders, the quorum must be no less than 33.33% of the outstanding ordinary shares. There is no general quorum requirement under Belgian law for ordinary meetings of shareholders, except in relation to decisions regarding certain matters.

------

• Compensation Committee. NASDAQ Stock Market Listing Rule 5605(d)(2) requires that compensation of officers must be determined by, or recommended to, the Board of Directors for determination, either by a majority of the independent directors, or a compensation committee comprised solely of independent directors. NASDAQ Stock Market Listing Rule 5605(e) requires that director nominees be selected, or recommended for selection, either by a majority of the independent directors or a nominations committee comprised solely of independent directors. Under Belgian law, we are not subject to any such requirements. In particular, we are not required by Belgian law to set up any compensation or nominations committees within our Board of Directors and are therefore not subject to any Belgian legal requirements as to the composition of such committees either. However, our articles of association provide that our Board of Directors may form committees from among its members. Our Board of Directors has set up and appointed a Nomination and Remuneration Committee. Pursuant article 7:100 of the CCA, only a majority of the members of the committee must qualify as independent as defined under article 7:100 of the CCA. Our Nomination and Remuneration Committee is currently comprised of four directors, all of whom are independent in accordance with article 7:100 of the CCA and the NASDAQ rules.

• Independent Director Majority on Board/Meetings . NASDAQ Stock Market Listing Rules 5605(b)(1) and (2) require that a majority of the Board of Directors must be comprised of independent directors and that independent directors must have regularly scheduled meetings at which only independent directors are present. We are not required under Belgian law to have more than two independent directors on our Board of Directors. However, our articles of association provide that our Board of Directors must be comprised of at least three directors, of which, pursuant to our corporate governance charter, at least three directors must be independent directors under Belgian law. We do not intend to require our independent directors to meet separately from the full Board of Directors on a regular basis or at all although the Board of Directors is supportive of its independent members voluntarily arranging to meet separately from the other members of our Board of Directors when and if they wish to do so.

ITEM 16H. MINE SAFETY DISCLOSURE

Not applicable.

ITEM 16I. DISCLOSURE REGARDING FOREIGN JURISDICTIONS THAT PREVENT INSPECTIONS

Not applicable.

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PART III

ITEM 17. FINANCIAL STATEMENTS

Not applicable.

ITEM 18. FINANCIAL STATEMENTS

See pages F-1 through F-73 of this Annual Report.

ITEM 19. EXHIBITS

The Exhibits listed in the Exhibit Index at the end of this Annual Report are filed as Exhibits to this Annual Report.

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##### [**Table of Contents**](#toc)
Index to Consolidated Financial Statements

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| | |
|:---|:---|
|  | Page |
| Annual Financial Statements for the Years Ended December 31, 2022, 2021 and 2020: |  |
| [Report of auditor, Independent Registered Public Accounting Firm (EY Réviseurs d'Entreprises / EY Bedrijfsrevisoren SRL/BV, Diegem, Belgium, PCAOB Auditor ID 1467)](#fin418841_2) | F-2 |
| [Consolidated Statements of Financial Position as of December 31, 2022 and 2021](#fin418841_3) | F-5 |
| [Consolidated Statements of Income (Loss) for the Years Ended December 31, 2022, 2021 and 2020](#fin418841_4) | F-6 |
| [Consolidated Statements of Comprehensive Income (Loss) for the Years Ended December 31, 2022, 2021 and 2020](#fin418841_5) | F-7 |
| [Consolidated Statements of Cash Flows for the Years Ended December 31, 2022, 2021 and 2020](#fin418841_6) | F-8 |
| [Consolidated Statements of Changes in Shareholders' Equity for the Years Ended December 31, 2022, 2021 and 2020](#fin418841_7) | F-9 |
| [Notes to the Consolidated Financial Statements](#fin418841_8) | F-10 |

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#### **Table of Contents**
Report of Independent Registered Public Accounting Firm

To the Shareholders and the Board of Directors of Celyad Oncology SA

Opinion on the Financial Statements

We

have audited the accompanying consolidated statements of financial position of Celyad Oncology SA (the Company) as of December 31, 2022 and 2021, the related consolidated statements of income (loss), comprehensive

income (loss)

,

cash flows, and changes in shareholders' equity for each of the three years in the period ended December 31, 2022, and the related notes (collectively referred to as the "consolidated financial statements"). In our opinion, the consolidated financial statements present fairly, in all material respects, the financial position of the Company at December 31, 2022 and 2021, and the results of its operations and its cash flows for each of the three years in the period ended December 31, 2022, in conformity with International Financial Reporting Standards (IFRS) as issued by the International Accounting Standards Board (IASB).

The Company's Ability to Continue as a Going Concern

The

accompanying consolidated financial statements have been prepared assuming that the Company will continue as a going concern. As discussed in Note 2 to the consolidated financial statements, the Company projects that its existing cash and cash equivalents will not be sufficient to fund its estimated operating and capital expenditures over at least the next 12 months from the date that the financial statements are issued, and has stated that substantial doubt exists about the Company's ability to continue as a going concern. Management's evaluation of the events and conditions and management's plans regarding these matters are also described in Note 2. The consolidated financial statements do not include any adjustments that might result from the outcome of this uncertainty.

Basis for Opinion

These financial statements are the responsibility of the Company's management. Our responsibility is to express an opinion on the Company's financial statements based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (PCAOB) and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement, whether due to error or fraud. The Company is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Company's internal control over financial reporting. Accordingly, we express no such opinion.

Our audits included performing procedures to assess the risks of material misstatement of the financial statements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements. We believe that our audits provide a reasonable basis for our opinion.

Critical Audit Matter

The critical audit matter communicated below is a matter arising from the current period audit of the financial statements that was communicated or required to be communicated to the audit committee and that: (1) relates to accounts or disclosures that are material to the financial statements and (2) involved our especially challenging, subjective or complex judgments. The communication of the critical audit matter does not alter in any way our opinion on the consolidated financial statements, taken as a whole, and we are not, by communicating the critical audit matter below, providing separate opinion on the critical audit matter or on the accounts or disclosures to which it relates.

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[**Table of Contents**](#toc)

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| | |
|:---|:---|
|  | Accounting for the sale of cell therapy manufacturing unit |
| Description of the matter | As described in Note 1 of the consolidated financial statements, in September 2022, the Company completed the sale of its cell therapy manufacturing unit to Ncardia BV ("Ncardia") for a total cash consideration of €6 million. Under this agreement, Ncardia acquired all assets related to the cell therapy manufacturing unit and all related employees joined Ncardia. Effective January 1, 2023, the Company executed additional agreements with Ncardia under which Ncardia acquired additional fixed assets, such as leasehold improvements and furniture, unrelated to the cell therapy manufacturing unit and separately sub-leased its headquarter building from Ncardia (collectively referred to with the sale of the cell therapy manufacturing unit as "the Transactions"). The Company accounted for the sale of its cell therapy manufacturing unit as a sale of assets and recognized a €5.2 million pre-tax gain.<br>Auditing the Company's determination that the sale of its cell therapy manufacturing unit did not meet the criteria of a discontinued operation was complex due to the judgment involved as to whether it represented a separate major line of business. Auditing the Transactions also required a high degree of effort due to the significant nature of their effect on the consolidated financial statements. |

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| | |
|:---|:---|
| How we addressed the matter in our audit | We obtained an understanding, evaluated the design and tested the operating effectiveness of controls over the Company's accounting treatment and related disclosures for the Transactions. This included testing controls over management's application of IFRS 5 Non-current Assets Held for Sale and Discontinued Operations and its accounting policies, specifically to determine whether the cell therapy manufacturing unit met the criteria of a discontinued operation.<br>Our audit procedures included, among others, testing the accuracy of the accounting impact calculations and evaluating the adequacy of the Company's disclosures related to the Transactions. We evaluated the appropriateness of the Company's application of the criteria for determining a discontinued operation by assessing the cell therapy manufacturing unit characteristics, such as relative size and role within the Company, reading the executed agreements to understand the nature of operations sold to Ncardia, assessing the business rationale of the Transactions and reading board minutes related to the Transactions. We performed external confirmation procedures over the legal agreements with Ncardia.  |

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/s/ EY Réviseurs d'Entreprises / EY Bedrijfsrevisoren SRL/BV

We have served as the Company's auditors since 2020

Diegem, Belgium

March 23, 2023

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CONSOLIDATED STATEMENTS OF FINANCIAL POSITION

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| | | | |
|:---|:---|:---|:---|
| (€'000) |  | As at December 31, | As at December 31, |
|  | Notes | 2022 | 2021 |
| NON-CURRENT ASSETS |  | 4 891 | 45 651 |
| Goodwill and Intangible assets | 7 | 864 | 36 168 |
| Property, Plant and Equipment | 8 | 309 | 3 248 |
| Non-current Trade and Other receivables | 9 |  | 2 209 |
| Non-current Grant receivables | 9 | 3 454 | 3 764 |
| Other non-current assets | 9 | 264 | 262 |
| CURRENT ASSETS |  | 14 825 | 34 292 |
| Trade and Other Receivables | 11 | 1 118 | 668 |
| Grant receivables | 11 |  | 1 395 |
| Other current assets | 11 | 1 017 | 2 211 |
| Short-term investments | 12 |  |  |
| Cash and cash equivalents | 13 | 12 445 | 30 018 |
| Assets held for sale | 8 | 245 |  |
| TOTAL ASSETS |  | 19 716 | 79 943 |
| EQUITY |  | 4 317 | 43 639 |
| Share Capital | 15 | 78 585 | 78 585 |
| Share premium | 15 | 6 317 | 6 317 |
| Other reserves | 15, 18 | 34 800 | 33 172 |
| Capital reduction reserve | 3, 15 | 234 562 | 234 562 |
| Accumulated deficit | 3, 15 | (349 947) | (308 997) |
| NON-CURRENT LIABILITIES |  | 4 973 | 22 477 |
| Bank loans | 24 |  |  |
| Lease liabilities | 24 | 118 | 1 730 |
| Recoverable Cash advances (RCAs) | 19 | 4 584 | 5 851 |
| Contingent consideration payable and other financial liabilities | 23 |  | 14 679 |
| Post-employment benefits | 17 | 13 | 53 |
| Other non-current liabilities | 21 | 258 | 164 |
| CURRENT LIABILITIES |  | 10 426 | 13 827 |
| Bank loans | 24 |  |  |
| Lease liabilities | 24 | 137 | 902 |
| Recoverable Cash advances (RCAs) | 19 | 437 | 362 |
| Trade payables | 22 | 4 752 | 6 611 |
| Other current liabilities | 22 | 5 100 | 5 952 |
| TOTAL EQUITY AND LIABILITIES |  | 19 716 | 79 943 |

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The accompanying notes form an integral part of these consolidated financial statements.

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CONSOLIDATED STATEMENTS OF INCOME (LOSS)

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| | | | | |
|:---|:---|:---|:---|:---|
| (€'000) |  | For the year ended December 31, | For the year ended December 31, | For the year ended December 31, |
|  | Notes | 2022 | 2021 | 2020 |
| Revenue | 25, 2 |  |  | 5 |
| Cost of sales | 2 |  |  |  |
| Gross profit |  |  |  | 5 |
| Research and Development expenses | 26 | (18 928) | (20 773) | (21 522) |
| General & Administrative expenses | 26 | (10 546) | (9 908) | (9 315) |
| Change in fair value of contingent consideration | 29 | 14 679 | 847 | 9 228 |
| Impairment of Oncology intangible assets | 29 | (35 084) |  |  |
| Other income | 28 | 9 360 | 4 909 | 4 731 |
| Other expenses | 28 | (338) | (1 466) | (114) |
| Operating Loss<sup>2</sup> |  | (40 857) | (26 391) | (16 987) |
| Financial income | 31 | 185 | 144 | 217 |
| Financial expenses | 31 | (198) | (255) | (434) |
| Loss before taxes |  | (40 870) | (26 502) | (17 204) |
| Income taxes | 32 | (65) | (10) |  |
| Loss for the period<sup>(1)</sup> |  | (40 935) | (26 512) | (17 204) |
| Weighted average number of shares outstanding |  | 22 593 956 | 15 604 014 | 13 942 344 |
| Basic and diluted loss per share (in €) |  | (1.81) | (1.70) | (1.23) |

---

<sup>[1]</sup> For 2022, 2021 and 2020, the Company does not have any non-controlling interests and the losses for the year are fully attributable to owners of the parent.

The accompanying notes form an integral part of these consolidated financial statements.

<sup>2</sup> The operating loss arises from the Company's loss for the period before deduction of financial income, financial expenses and income taxes. The purpose of this measure by Management is to identify the Company's results in connection with its operating activities.

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CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME / (LOSS)

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| | | | |
|:---|:---|:---|:---|
| (€'000) | For the year ended December 31, | For the year ended December 31, | For the year ended December 31, |
|  | 2022 | 2021 | 2020 |
| Loss of the year | (40 935) | (26 512) | (17 204) |
| Other comprehensive income/(loss) |  |  |  |
| Items that will not be reclassified to profit and loss | (15) | 554 | (197) |
| Remeasurements of post-employment benefit obligations, net of tax | (15) | 554 | (197) |
| Items that may be subsequently reclassified to profit or loss | 4 | 42 | (5) |
| Currency translation differences | 4 | 42 | (5) |
| Other comprehensive income / (loss) for the period, net of tax | (11) | 596 | (202) |
| Total comprehensive loss for the period | (40 946) | (25 916) | (17 406) |
| Total comprehensive loss for the period attributable to Equity Holders <sup>[2]</sup> | (40 946) | (25 916) | (17 406) |

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<sup>[2]</sup> For 2022, 2021 and 2020, the Company does not have any non-controlling interests and the losses for the year are fully attributable to owners of the parent.

The accompanying notes form an integral part of these consolidated financial statements.

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CONSOLIDATED STATEMENTS OF CASH FLOWS

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| | | | | |
|:---|:---|:---|:---|:---|
| (€'000) |  | For the year ended December 31, | For the year ended December 31, | For the year ended December 31, |
|  | Notes | 2022 | 2021 | 2020 |
| Cash Flow from operating activities |  |  |  |  |
| Loss for the period |  | (40 935) | (26 512) | (17 204) |
| Non-cash adjustments |  |  |  |  |
| Intangibles - Amortization and impairment | 7 | 613 | 217 | 197 |
| Property, plant & equipment - Depreciation<sup>(3)</sup> | 8 | 827 | 1 303 | 1 635 |
| Loss on disposal of Goodwill and Intangible assets | 28 | 58 |  |  |
| Loss on disposal of Property, plant and equipment | 28 | 132 | 1 | 10 |
| Gain on sales of Property, plant & equipment | 28 |  |  | (35) |
| Gain on sale of CTMU activities | 28 | (5 187) |  |  |
| Remeasurement of Leases | 28 | (169) |  |  |
| Provision for onerous contract | 21, 22 | 2 171 | 29 | 858 |
| Change in fair value of contingent consideration payable and other financial liabilities | 29 | (14 679) | (847) | (9 228) |
| Impairment of Oncology intangible assets | 29 | 35 084 |  |  |
| Remeasurement of Recoverable Cash Advances (RCAs) | 28 | (1 447) | 328 | (933) |
| Grant income (RCAs and others) | 28 | (2 047) | (4 178) | (3 089) |
| Share-based payment expense | 16 | 1 624 | 2 172 | 2 782 |
| Post-employment benefits | 17 | (40) | (561) | 216 |
| Change in working capital |  |  |  |  |
| Trade receivables, other (non-)current receivables |  | 306 | (1 559) | (1 148) |
| Trade payables, other (non-)current liabilities |  | (4 321) | 2 964 | (1 726) |
| Net cash used in operations |  | (28 010) | (26 643) | (27 665) |
| Cash Flow from investing activities |  |  |  |  |
| Acquisition of Property, Plant & Equipment | 8 | (123) | (331) | (150) |
| Acquisitions of Intangible assets | 7 |  | (62) | (169) |
| Proceeds from disposals of Property, plant & equipment | 8 |  |  | 235 |
| Proceeds from net investment in lease<sup>(3)</sup> | 11 | 235 | 267 | 241 |
| Proceeds from sale of CTMU activities | 8 | 6 000 |  |  |
| Proceeds from short-term investments | 9 | 1 090 |  |  |
| Net cash from/(used in) investing activities |  | 7 202 | (126) | 157 |
| Cash Flow from financing activities |  |  |  |  |
| Repayments of bank borrowings | 24 |  | (37) | (192) |
| Repayments of leases | 24 | (896) | (1 099) | (1 255) |
| Proceeds from issuance of shares and exercise of warrants | 15 | (124) | 36 568 |  |
| Proceeds from RCAs & other grants | 19 | 4 491 | 4 369 | 7 272 |
| Repayment of RCAs & other grants | 19 | (230) | (280) | (429) |
| Net cash from/(used in) financing activities |  | 3 241 | 39 521 | 5 396 |
| Net cash and cash equivalents at beginning of the period |  | 30 018 | 17 234 | 39 338 |
| Change in Cash and cash equivalents |  | (17 567) | 12 752 | (22 112) |
| Effects of exchange rate changes on cash and cash equivalents |  | (6) | 32 | 8 |
| Net cash and cash equivalents at the end of the period |  | 12 445 | 30 018 | 17 234 |

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The accompanying notes form an integral part of these consolidated financial statements.

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CONSOLIDATED STATEMENTS OF CHANGES IN SHAREHOLDERS' EQUITY

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| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| (€'000) | Share capital<br> (Note 15)<br> (non-distributable) | Share<br> premium<br> (Note 15)<br> (non-distributable) | Other reserves<br> (Note 18)<br> (distributable<sup>1</sup>) | Capital<br> reduction<br> reserve<br> (Note 15)<br> (distributable<sup>1</sup>) | Accumulated<br> deficit<br> (distributable<sup>1</sup>) | Total Equity |
| Balance as of January 1, 2020 | 48 513 | 43 349 | 28 181 | 191 213 | (265 637) | 45 619 |
| Share-based payments |  |  | 2 782 |  |  | 2 782 |
| Total transactions with owners, recognized directly in equity |  |  | 2 782 |  |  | 2 782 |
| Loss for the period |  |  |  |  | (17 204) | (17 204) |
| Currency Translation differences |  |  | (5) |  |  | (5) |
| Remeasurements of defined benefit obligation |  |  |  |  | (197) | (197) |
| Total comprehensive loss for the period |  |  | (5) |  | (17 402) | (17 406) |
| Balance as of December 31, 2020 | 48 513 | 43 349 | 30 958 | 191 213 | (283 039) | 30 994 |
| Balance as of January 1, 2021 | 48 513 | 43 349 | 30 958 | 191 213 | (283 039) | 30 994 |
| Capital increase | 30 072 | 8 900 |  |  |  | 38 972 |
| Transaction costs associated with capital increases |  | (2 583) |  |  |  | (2 583) |
| Reduction of share premium by absorption of losses |  | (43 349) |  | 43 349 |  |  |
| Share-based payments |  |  | 2 172 |  |  | 2 172 |
| Total transactions with owners, recognized directly in equity | 30 072 | (37 032) | 2 172 | 43 349 |  | 38 561 |
| Loss for the period |  |  |  |  | (26 512) | (26 512) |
| Currency Translation differences |  |  | 42 |  |  | 42 |
| Remeasurements of defined benefit obligation |  |  |  |  | 554 | 554 |
| Total comprehensive loss for the period |  | —&nbsp;&nbsp;&nbsp;&nbsp; | 42 |  | (25 958) | (25 916) |
| Balance as of December 31, 2021 | 78 585 | 6 317 | 33 172 | 234 562 | (308 997) | 43 639 |
| Balance as of January 1, 2022 | 78 585 | 6 317 | 33 172 | 234 562 | (308 997) | 43 639 |
| Share-based payments |  |  | 1 624 |  |  | 1 624 |
| Total transactions with owners, recognized directly in equity |  |  | 1 624 |  |  | 1 624 |
| Loss for the period |  |  |  |  | (40 935) | (40 935) |
| Currency Translation differences |  |  | 4 |  |  | 4 |
| Remeasurements of defined benefit obligation |  |  |  |  | (15) | (15) |
| Total comprehensive loss for the period |  | —&nbsp;&nbsp;&nbsp;&nbsp; | 4 |  | (40 950) | (40 946) |
| Balance as of December 31, 2022 | 78 585 | 6 317 | 34 800 | 234 562 | (349 947) | 4 317 |

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<sup>(1)</sup> Pursuant to Belgian law ("CCA"), the calculation of amounts available for distribution to shareholders, as dividends or otherwise, must be determined on the basis of the Company's standalone non-consolidated statutory financial statements of Celyad Oncology SA prepared under Belgian GAAP, and not on the basis of IFRS consolidated financial statements. For more information, see Note 15. 

The accompanying notes form an integral part of these consolidated financial statements.

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NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

NOTE 1: THE COMPANY

Unless otherwise indicated, "Celyad," "Celyad Oncology", "the Company," "our company," "the Group," "we," "us" and "our" refer to Celyad Oncology SA and its consolidated subsidiaries.

The Company is a biotechnology company focused on the research and development of chimeric antigen receptor T cell (CAR T) therapies for cancer.

Celyad Oncology SA was incorporated on July 24, 2007, under the name "Cardio3 BioSciences". Celyad is a limited liability company (Société Anonyme) governed by Belgian law with its registered office at Axis Parc, Rue Edouard Belin 2, B-1435 Mont-Saint-Guibert, Belgium (company number 0891.118.115).

The Company's ordinary shares are listed on NYSE Euronext Brussels and NYSE Euronext Paris regulated markets and the Company's American Depositary Shares (ADSs) are listed on the Nasdaq Global Market, all under the ticker symbol CYAD.

The Company has three fully owned subsidiaries (together, the Group) located in Belgium (Biological Manufacturing Services SA) and in the United States (Celyad Inc. and Corquest Medical, Inc.).

These consolidated financial statements have been approved for issuance by the Company's Board of Directors on March 23, 2023. These statements have been audited by EY Réviseurs d'Entreprises / EY Bedrijfsrevisoren SRL/BV, the statutory auditor of the Company and independent registered public accounting firm.

The annual report is available to the public free of charge to the above-mentioned address or via the Company's website (<u>https://celyad.com/investors/regulated-information/</u>).

Key event 2022

In September 2022, under the terms of an asset purchase agreement between the Company and Cellistic (the cell therapy development and manufacturing business of Ncardia BV), Cellistic agreed to acquire the Company's Good Manufacturing Practice (GMP) grade cell therapy manufacturing facility, including the existing facility and all related personnel (the "Manufacturing Business Unit", "Cell Therapy Manufacturing Unit", or "CTMU"), in Mont-Saint-Guibert, Belgium, for a total consideration of €6.0 million and effective as of January 1, 2023, the Group sold certain fixed assets to Cellistic and the Group also leased part of the building from Cellistic. For more information on the financial consequences of this transaction, refer to notes 7, 8, 26, 28, 30 and 37.

In October 2022, the Company announced its new business strategy "Celyad 2.0", under which the Company intends to focus on maximizing its intellectual property (IP) portfolio and strengthening its research focus. Based on this strategic and financial review, the Company has decided to discontinue the development of its remaining clinical programs. Under Celyad 2.0, the Company shifts from an organization focused on clinical development to one prioritizing R&D discovery and the monetization of its IP portfolio through partnerships, collaborations and license agreements. For more information on the financial consequences of this decision, refer to notes 7, 21, 22, 23, 24, 26, 28 and 29.

NOTE 2: GENERAL INFORMATION AND STATEMENT OF COMPLIANCE

The consolidated financial statements of the Group for the twelve months ended December 31, 2022, 2021 and 2020 (the "year" or "the period") include Celyad Oncology SA and its subsidiaries. The significant accounting policies used for preparing these consolidated financial statements are explained below.

Basis of preparation

The consolidated financial statements have been prepared on an historical cost basis, except for:

• Financial instruments – Fair value through profit or loss

• Contingent consideration and other financial liabilities

• Post-employment benefits liability

The policies have been consistently applied to all the years presented, unless otherwise stated.

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The consolidated financial statements are presented in euro and all values are presented in thousands (€000) except when otherwise indicated. Amounts have been rounded off to the nearest thousand and in certain cases, this may result in minor discrepancies in the totals and sub-totals disclosed in the financial tables. Certain reclasses to comparatives have been made to be consistent with current year presentation.

Statement of compliance

The consolidated financial statements of the Group have been prepared in accordance with International Financial Reporting Standards, International Accounting Standards and Interpretations (collectively, IFRSs) as issued by the International Accounting Standards Board (IASB).

The preparation of the consolidated financial statements in accordance with IFRS requires the use of certain critical accounting estimates. It also requires management to exercise its judgment in the process of applying the Group's accounting policies. The areas involving a higher degree of judgment or complexity, are areas where assumptions and estimates are significant to the financial statements. They are disclosed in note 5.

Going concern

The Group is pursuing a strategy to develop products and platforms that will help our partners to treat medical needs in oncology. Management has prepared detailed budgets and cash flow forecasts for the years 2023 and 2024. These forecasts reflect the new strategy of the Group and include significant expense and cash outflow estimations in relation to the development of its proprietary technology platforms and intellectual property, partly compensated by grants funding and tax incentives.

As of December 31, 2022, the Company had cash and cash equivalents of €12.4 million and no short-term investments. The Company projects that its existing cash and cash equivalents should be sufficient to fund operating expenses and capital expenditure requirements into the fourth quarter of 2023.

After due consideration of detailed budgets and estimated cash flow forecasts for the years 2023 and 2024, the Company projects that its existing cash and cash equivalents will not be sufficient to fund its estimated operating and capital expenditures over at least the next 12 months from the date that the financial statements are issued.

The Company is currently evaluating different financing options to obtain the required funding to extend the Company's cash runway beyond 12 months from the date the financial statements are issued. Financing options may include, but are not limited to, the public or private sale of equity, debt financings or funds from other capital sources, such as collaborations, strategic alliances and partnerships, or licensing arrangements with third parties. However, there can be no assurance that the Company will be able to secure additional financing, or if available, that it will be sufficient to meet its needs or available on favorable terms indicating a material uncertainty exists about the Company's ability to continue as a going concern.

The accompanying consolidated financial statements do not include any adjustments that might result from the outcome of this uncertainty. Accordingly, the consolidated financial statements have been prepared on a basis that assumes the Company will continue as a going concern and contemplates the realization of assets and satisfaction of liabilities and commitments in the ordinary course of business.

COVID-19 update

The long-term impact of COVID-19 on the Company's operations will depend on future developments, which are highly uncertain and cannot be predicted, including the emergence of new variants, such as Delta and Omicron, and, among other things, additional government restrictions intended to contain COVID-19's effects, but potential prolonged closures or other business disruptions may negatively affect its operations and the operations of its agents, contractors, consultants or collaborators, which could have a material adverse impact its results of operations and financial condition. To date, COVID-19 has had no material impact on the Company's operating results or cash flows.

War in Ukraine

In February 2022, Russia launched a military invasion of Ukraine. The ongoing military operations in Ukraine and the related sanctions targeted against Russia and Belarus may have an impact on the European and global economies. The Company has no operations or suppliers based in Ukraine, Belarus, or Russia, and consequently there has not been a negative impact on our operations to date.

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However, the general economic impacts of the conflict are unpredictable and could lead to market disruptions, including significant volatility in commodity prices, credit and capital markets. Given the continuing conflict, the operations of the Company could be disrupted due to the demise of commercial activity in impacted regions and due to the severity of sanctions on the businesses upon which the Company and its suppliers rely. Further, state-sponsored cyberattacks could expand as part of the conflict, which could adversely affect our ability to maintain or enhance key cyber security and data protection measures. To date, the Company has not experienced any material adverse impacts, but the Company is not able to reliably predict the potential impact of the conflict on its future business or operations.

Changes to accounting standards and interpretations

The Group has applied the same accounting policies and methods of computation in its 2022 year-end consolidated financial statements as compared to 2021, except for those that relate to new standards and interpretations.

None of the new standards, interpretations and amendments, which are effective for periods beginning after January 1, 2022 which have been issued by the IASB have a material effect on the Group's financial statements. None of the new standards, interpretations and amendments, which will be effective for periods beginning after January 1, 2023 and are not yet effective as of December 31, 2022 and/or not yet adopted by the European Union as of December 31, 2022, are expected to have a material effect on the Group's future financial statements as either they are not relevant to the Group's activities, or they require accounting which is consistent with the Group's current accounting policies.

NOTE 3: ACCOUNTING PRINCIPLES

Subsidiaries

Subsidiaries are all entities (including structured entities) over which the Group has control. The Group controls an entity when the Group is exposed to, or has rights to, variable returns from its involvement with the entity and has the ability to affect those returns through its power over the entity. Subsidiaries are fully consolidated from the date on which control is transferred to the Group. They are deconsolidated from the date control ceases.

Inter-company transactions, balances and unrealized gains on transactions between group companies are eliminated. Unrealized losses are also eliminated. When necessary, amounts reported by subsidiaries have been adjusted to conform with the Group's accounting policies.

FOREIGN CURRENCY TRANSLATION

Functional and presentation currency

Items included in the financial statements of each of the Group's entities are measured using the currency of the primary economic environment in which the entity operates ("the functional currency"). The consolidated financial statements are presented in Euros, which is the Group's presentation currency.

Transactions and balances

Foreign currency transactions (mainly USD) are translated into the functional currency using the applicable exchange rate on the transaction dates. Monetary assets and liabilities denominated in foreign currencies are retranslated at the presentation currency spot rate of exchange ruling at the reporting date.

Foreign currency exchange gains and losses arising from settling foreign currency transactions and from the retranslation of monetary assets and liabilities denominated in foreign currencies at the reporting date are recognized in the income statement.

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Non-monetary items that are measured in terms of historical cost in a foreign currency are translated using the exchange rates as of the dates of the initial transactions. Non-monetary items measured at fair value in a foreign currency are translated using the exchange rates at the date when the fair value is determined.

Group companies

The results and financial position of all group entities that have a functional currency different from the presentation currency are translated into the presentation currency as follows:

• Assets and liabilities for each statement of financial position presented are translated at the closing rate at the date of that statement of financial position;

• Income and expenses for each income statement are translated at average exchange rate (unless this average is not a reasonable approximation of the cumulative effect of the rates prevailing on the transaction dates, in which case income and expenses are translated at the rate on the dates of the transactions); and

• All resulting translation differences are recognized in other comprehensive income.

REVENUE

So far, the primary revenue generated by the Group relates to the sale of licenses.

Licensing revenue

The Group enters into license and/or collaboration agreements with third-party biopharmaceutical partners. Revenue under these arrangements may include non-refundable upfront payments, product development milestone payments, commercial milestone payments and/or sales-based royalty payments.

Upfront payments

License fees representing non-refundable payments received at the time of signature of license agreements are recognized as revenue upon signature of the license agreements when the Group has no significant future performance obligations and collectability of the fees is assured.

Milestone payments

Milestone payments represent amounts received from the Group's customers or collaborators, the receipt of which is dependent upon the achievement of certain scientific, regulatory, or commercial milestones. Under IFRS 15, milestone payments generally represent a form of variable consideration as the payments are likely to be contingent on the occurrence of future events. Milestone payments are estimated and included in the transaction price based on either the expected value (probability-weighted estimate) or most likely amount approach. The most likely amount is likely to be most predictive for milestone payments with a binary outcome (i.e., the Group receives all or none of the milestone payment). Variable consideration is only recognized as revenue when the related performance obligation is satisfied, and the Group determines that it is highly probable that there will not be a significant reversal of cumulative revenue recognized in future periods.

Royalty revenue

Royalty revenues arise from the Group's contractual entitlement to receive a percentage of product sales achieved by co-contracting parties. As the Group's co-contracting partners currently have no products based on a Celyad-technology approved for sale. The Group has not received any royalty revenue to date. Royalty revenues, if earned, will be recognized on an accrual basis in accordance with the terms of the contracts with the Group's customers when sales occur and there is reasonable assurance that the receivables from outstanding royalties will be collected.

Sales of goods (medical devices)

Sales of medical devices are recognized when the Group has fulfilled the performance obligations under the terms of the sales contract, which includes delivery of the promised goods.

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OTHER INCOME

Government Grants

The Group's grant income reported under 'Other income' in the consolidated statement of comprehensive loss is generated from: (i) recoverable cash advances (RCAs) granted by the Regional government of Wallonia; (ii) R&D tax credits granted by the Belgian federal government; and (iii) grants received from the European Commission under the Seventh Framework Program ("FP7"), Federal Belgian Institute for Health Insurance (Inami) and Regional authorities.

Government grants are recognized at their fair value (calculated based on present value of future repayment of grants) where there is reasonable assurance that the grant will be received, and the Group has complied with all attached conditions. Once a government grant is recognized, any related contingent liability (or contingent asset) is treated in accordance with IAS 37.

Government grants relating to costs are deferred and recognized in the consolidated statement of comprehensive loss over the period necessary to match them with the costs that they are intended to compensate.

Based on the nature of transactions, cash inflows received from government grants provide the entity with financing for the designated activity. They are in substance financing cash inflows consistent with the cash proceeds from RCAs and other grants and are disclosed in the consolidated statements of cash flows as "Cash Flow from financing activities".

The Group's grant income is recognized in the consolidated statement of comprehensive loss under "Other income/expense" and as a non-cash adjustment in "cash flows from operating activities" in the consolidated statements of cash flows.

Recoverable cash advances (RCAs)

The Group receives grants from the Walloon Region in the form of recoverable cash advances (RCAs).

RCAs are dedicated to support specific development programs. All RCA contracts, in essence, consist of three phases, i.e., the "research phase", the "decision phase" and the "exploitation phase". During the research phase, the Group receives funds from the Region based on statements of expenses. In accordance with IAS 20.10A and IFRS Interpretations Committee (IC)'s conclusion that contingently repayable cash received from a government to finance a research and development (R&D) project is a financial liability under IAS 32, 'Financial instruments; Presentation', the RCAs are initially recognized, concomitantly with the occurrence of subsidized expense, as a financial liability at fair value (calculated based on present value of future repayment of grants), determined as per IFRS 9.

The benefit (RCA grant component) consisting in the difference between the cash received (RCA proceeds) and the above-mentioned financial liability's fair value (RCA liability component) is treated as a government grant in accordance with IAS 20.

The RCA grant component is recognized in profit or loss under "Other income" on a systematic basis over the periods in which the entity recognizes the underlying R&D expenses subsidized by the RCA.

The fair market value adjustments to the RCA liability are recognized in the consolidated statement of comprehensive loss under "Other income/expense" and as a non-cash adjustment in "cash flows from operating activities" in the consolidated statements of cash flows.

The RCAs liability contains two components:

• The fixed part of the reimbursement of 30% is refundable based upon an agreed repayment schedule. The initial recognition at fair value is performed using the discount rate at the date of the convention and the assumption of exploitation until the end of repayment schedule.

• The variable part (from 70% and up to 170%) is refundable to the extent of the revenue generated within exploitation phase. The initial recognition at fair value of the variable part of the component is based on probability-weighted discounted cash flows estimated using Key assumptions listed in note 7.

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The sales-independent reimbursements and sales-dependent reimbursements are, in the aggregate (including the accrued interests), capped at 200% of the principal amount paid out by the Walloon Region.

The RCAs liability component (RCA financial liability) is subsequently measured at amortized cost using the cumulative catch-up approach under which the carrying amount of the liability is adjusted to the present value of the future estimated revenue, discounted at the liability's original effective interest rate. The resulting adjustment is recognized within profit or loss under "Other income/expense".

At the end of the research phase, the Group should within a period of six months decide whether or not to exploit the results of the research phase (decision phase). The exploitation phase may have a duration of up to 20 years. In the event the Group decides to exploit the results under an RCA, the relevant RCA becomes contingently refundable, and the fair value of the RCA liability adjusted accordingly, if required. For more information on the potential financial consequences of these exploitation decisions in terms of potential reimbursements and sales percentage fees to be paid to the Walloon Region, refer to note 19.

When the Group does not exploit (or ceases to exploit) the results of programs under an RCA, it has to notify the Region of this decision. This decision is the sole responsibility of the Group. The related liability is then discharged by the transfer of such results to the Region. Also, when the Group decides to renounce its rights to patents which may result from the research, title to such patents will be transferred to the Region. In that case, the RCA liability is extinguished and reflected in the statement of income (loss) under "Other income/expense".

R&D Tax credits

Since 2013, the Group applies for R&D tax credits, a tax incentive measure for European SME's established by the Belgian federal government. When capitalizing its R&D expenses under the tax reporting framework, the Group may either i) get a reduction of its taxable income (at current income tax rate applicable); or ii) if no sufficient taxable income is available, apply for the refund of the unutilized tax credits, calculated on the R&D expenses amount for the year. Such settlement occurs at the earliest 5 financial years after the tax credit application filed by the Group.

Considering that R&D tax credits are ultimately paid by the public authorities, the related benefit is treated as a government grant under IAS 20 and booked into other income, in order to match the R&D expenses subsidized by the grant.

Other government grants

The Group has received and will continue to apply for grants from European (FP7), Regional authorities and Federal Belgian Institute for Health Insurance (Inami). These grants are dedicated to partially finance early stage projects such as fundamental research, applied research, prototype design, etc.

To date, all grants received are not associated with any conditions. As per each grant agreement, grants are paid upon submission by the Group of a statement of eligible expenses. The Group incurs expenses first and then submits application for the grant receipt according to the terms of the grant agreement.

These government grants are recognized in profit or loss under "Other income" on a systematic basis over the periods in which the entity recognizes the underlying R&D expenses subsidized.

INTANGIBLE ASSETS

The following categories of intangible assets apply to the current Group operations:

Separately acquired intangible assets

Intangible assets acquired from third parties are recognized at cost, if and only if it is probable that future economic benefits associated with the asset will flow to the Group, and that the cost can be measured reliably. Subsequent payments of contingent consideration are capitalized when incurred. Following initial recognition, intangible assets are carried at cost less any accumulated amortization and accumulated impairment losses.

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The useful life of intangible assets is assessed as finite, except for Goodwill. They are amortized over the expected useful economic life and assessed for impairment whenever there is an indication that the intangible asset may be impaired. The amortization period and the amortization method for an intangible asset with a finite useful life are reviewed at least at each financial year end. Changes in the expected useful life or the expected pattern of consumption of future economic benefits embodied in the asset are accounted for by changing the amortization period or method, as appropriate, and are treated as changes in accounting estimates and applied prospectively. The amortization expense on intangible assets with finite lives is recognized in the income statement in the expense category consistent with the function of the intangible asset.

Patents, Licenses and Trademarks

Licenses for the use of intellectual property are granted for a period corresponding to the intellectual property of the assets licensed. Amortization is calculated on a straight-line basis over this useful life.

Patents and licenses are amortized over the period corresponding to the intellectual property (IP) protection and are assessed for impairment whenever there is an indication these assets may be impaired. Indication of impairment is related to the value of the patent demonstrated by the preclinical and clinical results of the technology.

Software

Software only concerns acquired computer software licenses. Software is capitalized on the basis of the costs incurred to acquire and bring to use the specific software. These costs are amortized over their estimated useful lives of three to five years on a straight-line basis.

Intangible assets acquired in a business combination

Goodwill

Goodwill is an asset representing the future economic benefits arising from other assets acquired in a business combination that are not individually identified and separately recognized. Goodwill is measured as a residual at the acquisition date, as the excess of the fair value of the consideration transferred and the assets and liabilities recognized (in accordance with IFRS 3).

Goodwill has an indefinite useful life and is not amortized but tested for impairment at least annually or more frequently whenever events or changes in circumstances indicate that goodwill may be impaired, as set forth in IAS 36 (Impairment of Assets).

Goodwill arising from business combinations is allocated to cash generating units, which are expected to receive future economic benefits from synergies that are most likely to arise from the acquisition. These cash generating units form the basis of any future assessment of impairment of the carrying value of the acquired goodwill.

In-process research and development costs

The In-process research and development costs ("IPR&D") acquired as part of a business combination are measured at fair value at the date of acquisition. Subsequent to initial recognition, it is reported at cost and is subject to annual impairment testing until the date the projects are available for use and from that moment, the IPR&D will be amortized over its remaining useful economic life.

Subsequent R&D expenditure can be capitalized as part of the IPR&D only to the extent that IPR&D is in development stage, i.e., when such expenditure meets the recognition criteria of IAS 38. In line with biotech industry practice, the Group determines that 'development stage' under IAS 38 is reached when the product candidate gets regulatory approval (upon Phase III completion). Therefore, any R&D expenditure incurred between the acquisition date and the development stage should be treated as part of research phase and expensed periodically in the income statement.

Internally generated intangible assets

Except qualifying development expenditure (discussed below), internally generated intangible assets are not capitalized. Expenditure is reflected in the income statement in the year in which the expenditure is incurred.

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Research and development costs

Research costs are expensed as incurred. Development expenditures on an individual project are recognized as an intangible asset when the Group can demonstrate:

a) The technical feasibility of completing the intangible asset so that it will be available for use or sale.

b) Its intention to complete the intangible asset and use or sell it.

c) Its ability to use or sell the intangible asset.

d) How the intangible asset will generate probable future economic benefits. Among other things, the entity can demonstrate the existence of a market for the output of the intangible asset or the intangible asset itself or, if it is to be used internally, the usefulness of the intangible asset.

e) The availability of adequate technical, financial and other resources to complete the development and to use or sell the intangible asset.

f) Its ability to measure reliably the expenditure attributable to the intangible asset during its development.

For the industry in which the Group operates, the life science industry, criteria a) and d) tend to be the most difficult to achieve. Experience shows that in the Biotechnology sector technical feasibility of completing the project is met when such project completes successfully Phase III of its development. For medical devices this is usually met at the moment of CE marking.

Following initial recognition of the development expenditure as an asset, the cost model is applied requiring the asset to be carried at cost less any accumulated amortization and accumulated impairment losses.

Amortization of the asset begins when development has been completed and the asset is available for use. It is amortized over the period of expected future benefit. Amortization is recorded in Research & Development expenses. During the period of development, the asset is tested for impairment annually, or earlier when an impairment indicator occurs. As of statement of financial position dates, only the development costs of C-Cathez have been capitalized under "Development costs" and are being amortized over a period of 17 years which corresponds to the period over which the intellectual property is protected.

PROPERTY, PLANT AND EQUIPMENT

Property, plant and equipment is stated at cost, net of accumulated depreciation and/or accumulated impairment losses, if any. Repair and maintenance costs are recognized in the income statement as incurred.

Depreciation is calculated on a straight-line basis over the estimated useful life of the asset as follows:

• Land and buildings: 15 to 20 years

• Plant and equipment: 5 to 15 years

• Laboratory equipment: 3 to 5 years

• Office furniture: 3 to 10 years

• Leasehold improvements: based on remaining duration of office building lease

• Right-of-use assets: over lease term

An item of property, plant and equipment and any significant part initially recognized is derecognized upon disposal or when no future economic benefits are expected from its use or disposal. Any gain or loss arising on derecognition of the asset (calculated as the difference between the net disposal proceeds and the carrying amount of the asset) is included in the income statement when the asset is derecognized.

The assets' residual values, useful lives and methods of depreciation are reviewed at each financial year end, and adjusted prospectively, if applicable.

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LEASES

The determination of whether an arrangement is, or contains, a lease is based on the substance of the arrangement at inception date whether fulfilment of the arrangement is dependent on the use of a specific asset or assets, or the arrangement conveys a right to use the asset.

The Group leases various offices, facilities, cars and IT-equipment.

Leases are recognized as a right-of-use asset, presented under "Property, Plant and Equipment", and a corresponding liability at the date at which the leased asset is available for use by the Group. Each lease payment is allocated between the liability and finance cost. The finance cost is charged to profit or loss over the lease period so as to produce a constant periodic rate of interest on the remaining balance of the liability for each period. The right-of-use asset is depreciated over the shorter of the asset's useful life and the lease term on a straight-line basis.

Assets and liabilities arising from a lease are initially measured on a present value basis. Lease liabilities include the net present value of the following lease payments:

• Fixed payments (including in-substance fixed payments), less any lease incentives receivable;

• Variable lease payment that are based on an index or a rate;

• Amounts expected to be payable by the lessee under residual value guarantees;

• The exercise price of a purchase option if the lessee is reasonably certain to exercise that option; and

• Payments of penalties for terminating the lease, if the lease term reflects the lessee exercising that option.

The lease term covers the non-cancellable period for which the Group has the right to use an underlying asset, together with both:

(a) Periods covered by an option to extend the lease if the Group is reasonably certain to exercise that option; and

(b) Periods covered by an option to terminate the lease if the Group is reasonably certain not to exercise that option.

The lease payments are discounted using the interest rate implicit in the lease. If that rate cannot be determined, the lessee's incremental borrowing rate is used, being the rate that the lessee would have to pay to borrow the funds necessary to obtain an asset of similar value in a similar economic environment with similar terms and conditions.

Right-of-use assets are measured at cost comprising the following:

• The amount of the initial measurement of lease liability;

• Any lease payments made at or before the commencement date less any lease incentives received;

• Any initial direct costs; and

• Restoration costs.

Payments associated with short-term leases and leases of low-value assets are recognized on a straight-line basis as an expense in profit or loss. Short-term leases are leases with a lease term of 12 months or less. Low-value assets primarily comprise IT-equipment.

Until September 2022, the Group subleased some office space it leases from a head lessor. In its capacity as intermediate lessor, the Group assesses whether the sublease is a finance or operating lease in the context of the right-of-use asset being leased. The sublease is classified as a finance lease if it transfers substantially all the risks and rewards incidental to ownership of the underlying right-of-use asset. It is classified as an operating lease if it does not transfer substantially all the risks and rewards incidental to ownership of the underlying right-of-use asset.

From time to time, the Group may enter into sale and leaseback transactions. When a sale occurs, both the seller-lessee and the buyer-lessor account for the leaseback in the same manner as any other lease. Specifically, the seller-lessee recognizes a lease liability and right-of-use asset for the leaseback (subject to the optional exemptions for short-term leases and leases of low-value assets).

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IMPAIRMENT OF NON-FINANCIAL ASSETS

The Group assesses at each reporting date whether there is an indication that an asset may be impaired, unless there are indications of impairment at other points throughout the period. If any indication exists, or when annual impairment testing for an asset is required, the Group estimates the asset's recoverable amount. An asset's recoverable amount is the higher of an asset's or cash-generating unit's (CGU) fair value less costs to sell and its value in use and is determined for an individual asset, unless the asset does not generate cash inflows that are largely independent of those from other assets or group of assets. In assessing value in use, the estimated future cash flows are discounted to their present value using a pre-tax discount rate that reflects current market assessments of the time value of money and the risks specific to the asset. In determining fair value less costs to sell, an appropriate valuation model is used based on the discounted cash-flow model. For intangible assets under development (like IPR&D), only the fair value less costs to sell reference is allowed in the impairment testing process.

Where the carrying amount of an asset or CGU exceeds its recoverable amount, an impairment loss is immediately recognized as an expense and the asset carrying value is written down to its recoverable amount.

An assessment is made at each reporting date as to whether there is any indication that previously recognized impairment losses may no longer exist or may have decreased. If such indication exists, the Group estimates the asset's or cash-generating unit's recoverable amount. A previously recognized impairment loss is reversed only if there has been a change in the assumptions used to determine the asset's recoverable amount since the last impairment loss was recognized. The reversal is limited so that the carrying amount of the asset does not exceed its recoverable amount, nor exceed the carrying amount that would have been determined, net of depreciation, had no impairment loss been recognized for the asset in prior years. Such reversal is recognized in the income statement unless the asset is carried at a revalued amount, in which case the reversal is treated as a revaluation increase. An impairment loss recognized on goodwill is however not reversed in a subsequent period.

As of the statement of financial position dates, the Group has two cash-generating units which consist of the development and commercialization activities on:

• CYAD products candidate series based on CAR T technology, for the immune-oncology segment; and

• C-Cath ez commercialized medical device, for the cardiology segment.

Indicators of impairment used by the Group are the preclinical and clinical results obtained with the technology.

CASH AND CASH EQUIVALENTS

Cash and cash equivalents in the statement of financial position comprise cash at banks and on hand and very short-term deposits with an original maturity of three months or less. Cash and cash equivalents are carried in the statement of financial position at their nominal value.

FINANCIAL ASSETS

Classification

The Group classifies its financial assets in accordance with IFRS 9 categories for measurement purposes. The classification depends on the purpose for which the financial assets were acquired. Management determines the classification of its financial assets at initial recognition.

'Amortized cost' measurement category refers to loans and receivables which are non-derivative financial assets, with fixed or determinable payments that are not quoted in an active market. They are included in current assets, except for maturities greater than 12 months after the end of the reporting period which are classified as non-current assets. This measurement category comprises "cash and cash equivalents", "short-term investments", and relevant financial assets within "(non-) current trade and other receivables", "(non-) current grant receivables" and "other (non-) current assets".

Initial recognition and measurement

All financial assets are recognized initially at fair value plus or minus, in the case of a financial asset not at fair value through profit or loss, directly attributable transaction costs.

Subsequent measurement

After initial measurement, financial assets are subsequently measured at amortized cost using the effective interest rate method (EIR), less impairment. Amortized cost is calculated by taking into account any discount or premium on acquisition and fee or costs that are an integral part of the EIR. The EIR amortization is included in finance income in the income statement under "Financial income". The losses arising from impairment are recognized in the income statement under "Other expenses".

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Impairment of financial assets

In relation to the impairment of financial assets, IFRS 9 requires an expected credit loss model. The expected credit loss model requires the Group to account for expected credit losses and changes in those expected credit losses at each reporting date to reflect changes in credit risk since initial recognition of the financial assets. In other words, it is no longer necessary for a credit event to have occurred before credit losses are recognized.

The Group considers there is no significant additional credit risk related to this receivable, which would not have been captured by the discounting effect, both at inception of the receivable and at the reporting date. As such, no additional ECL allowance has been recognized for this financial asset or any other financial asset.

Financial assets carried at amortized cost

For financial assets carried at amortized cost the Group first assesses individually whether objective evidence of impairment exists individually for financial assets that are individually significant, or collectively for financial assets that are not individually significant. If the Group determines that no objective evidence of impairment exists for an individually assessed financial asset, it includes the asset in a group of financial assets with similar credit risk characteristics and collectively assesses them for impairment. Assets that are individually assessed for impairment and for which an impairment loss is, or continues to be, recognized are not included in a collective assessment of impairment.

If there is objective evidence that an impairment loss has been incurred, the amount of the loss is measured as the difference between the asset's carrying amount and the present value of estimated future cash flows.

The present value of the estimated future cash flows is discounted at the financial assets' original effective interest rate. If a loan has a variable interest rate, the discount rate for measuring any impairment loss is the current effective interest rate.

The carrying amount of the asset is reduced through the use of an allowance account and the amount of the loss is recognized in the income statement under "Other expenses". Interest income continues to be accrued on the reduced carrying amount and is accrued using the rate of interest used to discount the future cash flows for the purpose of measuring the impairment loss. The interest income is recorded as part of finance income in the income statement under "Financial income". Loans together with the associated allowance are written off when there is no realistic prospect of future recovery. If, in a subsequent year, the amount of the estimated impairment loss increases or decreases because of an event occurring after the impairment was recognized, the previously recognized impairment loss is increased or reduced by adjusting the allowance account. If a future write-off is later recovered, the recovery is credited to the income statement.

FINANCIAL LIABILITIES

Classification

The Group's financial liabilities include "bank loans", "lease liabilities", "recoverable cash advances", "contingent consideration and other financial liabilities", "trade payables" and relevant financial liabilities within "Other (non-) current liabilities".

The Group classifies and measures its financial liabilities at 'amortized cost' using the effective interest method, except "contingent consideration and other financial liabilities" which are classified and measured at 'fair value through profit or loss'.

Initial recognition and measurement

Financial liabilities are initially measured at fair value. Transactions costs that are directly attributable to the acquisition or issue of financial liabilities are added or deducted from the fair value of the financial liabilities, as appropriate, on initial recognition.

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Subsequent measurement

The subsequent measurement of financial liabilities depends on their classification as explained above. In particular:

Contingent consideration

The contingent consideration and other financial liabilities are recognized and measured at fair value at the acquisition date. After initial recognition, contingent consideration arrangements that are classified as liabilities are re-measured at fair value with changes in fair value recognized in profit or loss in accordance with IFRS 3 and IFRS 9. Therefore, contingent payments will not be eligible for capitalization but will simply reduce the contingent consideration liability.

Details regarding the valuation of the contingent consideration are disclosed in note 23.

Recoverable cash advances

Recoverable cash advances granted by the Walloon Region are subsequently measured at amortized cost using the cumulative catch-up approach, as described above.

Trade payables and other payables

After initial recognition, trade payables and other payables are measured at amortized cost using the effective interest method.

Loans and borrowings

After initial recognition, interest bearing loans and borrowings are subsequently measured at amortized cost using the effective interest rate method. Gains and losses are recognized in the income statement when the liabilities are derecognized.

Derecognition

A financial liability is derecognized when the obligation under the liability is discharged or cancelled or expires.

When an existing financial liability is replaced by another from the same lender on substantially different terms, or the terms of an existing liability are substantially modified, such an exchange or modification is treated as a derecognition of the original liability and the recognition of a new liability, and the difference in the respective carrying amounts is recognized in the income statement under "Change in fair value of contingent consideration" or "Other expenses".

PROVISIONS

Provisions are recognized when the Group has a present obligation (legal or constructive) as a result of a past event, it is probable that an outflow of resources embodying economic benefits will be required to settle the obligation and a reliable estimate can be made of the amount of the obligation. Where the Group expects some or all of a provision to be reimbursed, for example under an insurance contract, the reimbursement is recognized as a separate asset but only when the reimbursement is virtually certain. The expense relating to any provision is presented in the income statement net of any reimbursement. If the effect of the time value of money is material, provisions are discounted using a current pre-tax rate that reflects, where appropriate, the risks specific to the liability. Where discounting is used, the increase in the provision due to the passage of time is recognized as a finance cost.

Employee benefits

Post-employment plan

The Group operates a pension plan which requires defined contributions (DC) to be funded by the Group externally at a third-party insurance company. Under Belgian law, an employer must guarantee a minimum rate of return on the Group's contributions and thus it is treated as defined benefit plan under IAS 19. Therefore, any pension plan (including DC plans) organized in Belgium is treated as defined benefit plans under IAS 19.

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At the statement of financial position dates, the minimum rates of return guaranteed by the Group are as follows, in accordance with the law of 18 December 2015:

• 1.75% for the employer's contributions paid as from 1 January 2016 (variable rate based on Governmental bond OLO rates, with a minimum of 1.75% and a maximum of 3.75%);

• 3.25% (fixed rate) for the employer's contributions paid until 31 December 2015.

The cost of providing benefits is determined using the projected unit credit (PUC) method, with actuarial valuations being carried out at the end of each annual reporting period, with the assistance of an independent actuarial firm.

The liability recognized in the statement of financial position in respect of the pension plans is the present value of the defined benefit obligation at the end of the reporting period less the fair value of plan assets. The present value of the defined benefit obligation is determined by discounting the estimated future cash outflows using interest rates of high-quality corporate bonds that are denominated in the currency in which the benefits will be paid, and that have terms to maturity approximating to the terms of the related pension obligation.

The current service cost of the defined benefit plan, recognized in the income statement as part of the operating costs, reflects the increase in the defined benefit obligation resulting from employee service in the current year, benefit changes, curtailments and settlements.

Past-service costs are recognized immediately in the income statement.

The net interest cost is calculated by applying the discount rate to the net balance of the defined benefit obligation and the fair value of plan assets. This cost is included in the operating costs in the income statement.

Actuarial gains and losses arising from experience adjustments and changes in actuarial assumptions are charged or credited to other comprehensive income in the period in which they arise.

Short-term benefits

Short-term employee benefits are those expected to be settled wholly before twelve months after the end of the annual reporting period during which employee services are rendered, but do not include termination benefits such as wages, salaries, profit-sharing and bonuses and non-monetary benefits paid to current employees.

The undiscounted amount of the benefits expected to be paid in respect of services rendered by employees in an accounting period is recognized in that period. The expected cost of short-term compensated absences is recognized as the employees render services that increase their entitlement or, in the case of non-accumulating absences, when the absences occur, and includes any additional amounts the entity expects to pay as a result of unused entitlements at the end of the period.

Share-based payments

Certain employees, managers and members of the Board of Directors of the Group receive remuneration, as compensation for services rendered, in the form of share-based payments which are "equity-settled".

Measurement

The cost of equity-settled share-based payments is measured by reference to the fair value at the date on which they are granted. The fair value is determined by using an appropriate pricing model, further details are given in note 16.

Recognition

The cost of equity-settled share-based payments is recorded as an expense, together with a corresponding increase in equity, over the period in which the service conditions are fulfilled. The cumulative expense recognized for equity-settled transactions at each reporting date until the vesting date reflects the extent to which the vesting period has expired and the Group's best estimate of the number of equity instruments that will ultimately vest.

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Modification

Where the terms of an equity-settled transaction award are modified, the minimum expense recognized is the expense as if the terms had not been modified, if the original terms of the award were met. An additional expense is recognized for any modification that increases the total fair value of the share-based payment transaction or is otherwise beneficial to the employee as measured at the date of modification.

The incremental fair value granted is the difference between the fair value of the modified equity instrument and the original equity instrument, both estimated as at the date of the modification. If the modification occurs during the vesting period, the incremental fair value granted is included in the measurement of the amount recognized for services received over the period from the modification date until the date when the modified equity instruments vest, in addition to the amount based on the grant date fair value of the original equity instruments, which is recognized over the remainder of the original vesting period. If the modification occurs after vesting date, the incremental fair value granted is recognized immediately, or over the vesting period if the employee is required to complete an additional period of service before becoming unconditionally entitled to those modified equity instruments.

Forfeiture

An equity-settled award can be forfeited with the departure of a beneficiary before the end of the vesting period, or cancelled and replaced by a new equity settled award. If a new award is substituted for the cancelled award, and designated as a replacement award on the date that it is granted, the cancelled and new awards are treated as if they were a modification of the original award, as described in the previous paragraph.

Cancellation

If the cancellation occurs during the vesting period, it is treated as an acceleration of vesting, and the Group recognizes immediately the amount that would otherwise have been recognized for services received over the remainder of the vesting period. If the cancellation occurs after the vesting period, no adjustments will be made to the accounting.

INCOME TAXES

Tax is recognized in the income statement, except to the extent that it relates to items recognized in other comprehensive income or directly in equity. In this case, the tax is also recognized in other comprehensive income or directly in equity, respectively.

Deferred tax

Deferred tax is provided using the liability method on temporary differences at the reporting date between the tax bases of assets and liabilities and their carrying amounts for financial reporting purposes.

Deferred tax liabilities are recognized for all taxable temporary differences, except:

• Where the deferred tax liability arises from the initial recognition of goodwill or of an asset or liability in a transaction that is not a business combination and, at the time of the transaction, affects neither the accounting profit nor taxable profit or loss;

• In respect of taxable temporary differences associated with investments in subsidiaries, associates and interests in joint ventures, where the timing of the reversal of the temporary differences can be controlled and it is probable that the temporary differences will not reverse in the foreseeable future.

Deferred tax assets are recognized for all deductible temporary differences, carry forward of unused tax credits and unused tax losses (except if the deferred tax asset arises from the initial recognition of an asset or liability in a transaction other than a business combination and that, at the time of the transaction affects neither accounting nor taxable profit or loss), to the extent that it is probable that taxable profit will be available against which the deductible temporary differences, and the carry forward of unused tax credits and unused tax losses can be utilized.

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The carrying amount of deferred tax assets is reviewed at each reporting date and reduced to the extent that it is not probable that sufficient taxable profit will be available to allow all or part of the deferred tax asset to be utilized. Unrecognized deferred tax assets are reassessed at each reporting date and are recognized to the extent that it has become probable that future taxable profits will allow the deferred tax asset to be recovered.

Deferred tax assets and liabilities are measured at the tax rates that are expected to apply in the year when the asset is realized or the liability is settled, based on tax rates (and tax laws) that have been enacted or substantively enacted at the reporting date.

Deferred tax assets and deferred tax liabilities are offset, if a legally enforceable right exists to set off current tax assets against current income tax liabilities and the deferred taxes relate to income taxes levied by the same taxation authority or either the same taxable entity or different taxable entities where there is an intention to settle the balances on a net basis.

EARNINGS (LOSS) PER SHARE

The basic net profit/(loss) per share is calculated based on the weighted average number of shares outstanding during the period.

The diluted net profit/(loss) per share is calculated based on the weighted average number of shares outstanding including the dilutive effect of potentially dilutive ordinary shares such as warrants and convertible debts. Potentially dilutive ordinary shares should be included in diluted earnings (loss) per share when and only when their conversion to ordinary shares would decrease the net profit per share (or increase net loss per share).

EQUITY

The basic net profit/(loss) per share is calculated based on the weighted average number of shares outstanding during the period. The equity is comprised of the following (further details are given in note 15);

• Share capital: Share capital is comprised of the nominal amount of the parent's ordinary shares. This capital is not distributable in the form of dividends under Belgian Companies and Associations Code.

• Share premium: Share premium is comprised of: (1) the amount received attributable to share capital, in excess of the nominal amount of shares issued by the parent company, reduced by; (2) issuance costs directly attributable to the capital increase; and (3) absorption of the accumulated deficit into the share premium, as approved by the Company's shareholders in accordance with Belgian Companies and Associations Code.

• Other reserves: Other reserves are comprised of: (1) Share-base payment reserve; (2) Other equity reserve from conversion of convertible loan in 2013; and (3) Currency Translation differences.

• Capital reduction reserve: Capital reduction reserve is comprised of the absorption of historical losses of the Company into the share premium, as approved by the Company's shareholders in accordance with Belgian Companies and Associations Code.

• Accumulated deficit: Accumulated deficit is comprised of cumulative historical losses of the Company.

ASSETS HELD FOR SALE

In accordance with IFRS 5, Non-current Assets Held for Sale and Discontinued Operations, non-current assets (including property, plant and equipment and intangible assets) and disposal groups (a group of assets to be disposed of) are classified as held for sale if their carrying amount will be recovered principally through a sale transaction and when the following conditions are met: i) management is committed to a plan to sell; ii) the asset or disposal group is available for immediate sale; iii) an active program to locate a buyer is initiated; iv) the sale is highly probably, within 12 months of classification as held for sale; v) the asset or disposal group is being actively marketed for sale at a sales price reasonable in relation to its fair value; and vi) actions required to complete the plan indicate that it is unlikely that plan will be significantly changed or withdrawn.

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Non-current assets or disposal groups held-for-sale are measured at the lower of their carrying amount and fair value less costs to sell, as appropriate. Depreciation and amortization on these assets cease when they meet the criteria to be classified as non-current assets held for sale. Non-current assets held for sale are presented in the consolidated statement of financial position as a line item entitled "Assets held for sale".

#### NOTE 4: RISK MANAGEMENT

#### Financial risk factors

#### Interest rate risk
The interest rate risk is very limited as the Group has only a limited amount of finance leases and no outstanding bank loans. So far, because of the immateriality of the exposure, the Group did not enter into any interest hedging arrangements.

#### Credit risk
The Group has a limited amount of trade receivables due to the fact that sales to third parties are not significant and thus the Group's credit risk arises mainly from cash and cash equivalents and deposits with banks and financial institutions. The Group only works with international reputable commercial banks and financial institutions.

The maximum credit risk, to which the Group is theoretically exposed as at the statement of financial position date, is the carrying amount of financial assets. Given the current nature and size of operations of the Group, the requirement of the Group to measure the loss allowance for a financial instrument at an amount equal to the lifetime expected credit losses (ECL), mainly apply to trade and other receivables (resulting mainly from the amendment of the Mesoblast license agreement). The Group recognized a bad debt accrual on this receivable at the reporting date and considers there is no significant additional credit risk related to this receivable. As such, no additional ECL allowance has been recognized for this asset or any other financial asset.

#### Foreign exchange risk
The Group is exposed to foreign exchange risk as certain collaborations or supply agreements of raw materials are denominated in USD. Moreover, the Group has also investments in foreign operations, whose net assets are exposed to foreign currency translation risk (USD). So far, because of the immateriality of the exposure, the Group did not enter into any currency hedging arrangements.

At December 31, 2022, the foreign exchange risk exposure exists mainly on the cash denominated in USD.

A depreciation of 1% on the USD versus EUR would translate into an unrealized foreign exchange loss of €9k for the Group at December 31, 2022.

#### Liquidity risk
The Group monitors its risk to a shortage of funds using a recurring liquidity planning tool. Refer to note 5 for the going concern assessment.

The Group's objective is to maintain a balance between continuity of funding and flexibility through the use of bank deposit and leases.

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#### **Table of Contents**
Refer to note 23 for an analysis of the Group's non-derivative financial liabilities into relevant maturity groupings based on the remaining period at the statement of financial position date to the contractual maturity date. The amounts disclosed in the table are the contractual undiscounted cash flows.

Capital management

The Group's objectives when managing capital are to safeguard the Group's ability to continue as a going concern in order to provide returns for shareholders and benefits for other stakeholders and to maintain an adequate structure to limit to cost of capital.

NOTE 5: CRITICAL ACCOUNTING ESTIMATES AND JUDGMENTS

The preparation of the Group's financial statements requires Management to make judgments, estimates and assumptions that affect the reported amounts of revenues, expenses, assets and liabilities, and the disclosure of contingent liabilities, at the end of the reporting period.

Estimates and judgments are continually evaluated and are based on historical experience and other factors, including expectations of future events that are believed to be reasonable under the circumstances. Uncertainty about these assumptions and estimates could result in outcomes that require a material adjustment to the carrying amount of the asset or liability affected in future periods.

In the process of applying the Group's accounting policies, Management has made judgments and has used estimates and assumptions concerning the future. The resulting accounting estimates will, by definition, seldom equal the related actual results. The estimates and assumptions that have a significant risk of causing a material adjustment to the carrying amounts of assets and liabilities within the next financial year are addressed below.

Going Concern

When assessing going concern, the Board of Directors considers mainly the following factors:

• The treasury available at the statement of financial position date;

• The cash burn projected in accordance with the approved budget for next 12-month period as from the date the financial statements are issued, which are subject to judgments by management while considering all information available at the reporting date such as significant expenses and cash outflows in relation to – among others- the ongoing clinical trials, the continuation of research and development projects, and the scaling-up of the Company's manufacturing facilities;

• The availability of grant funding and outcome of ongoing and future grant applications payback loan to be received for the next 12-month period; and

• The financial facilities open to the company for raising new funds by capital increase operations.

Revenue

The recognition of revenue relating to license and collaboration agreements involves management estimates and requires judgement as to:

(i) Classifying the license agreement (right-to-use or right-to-access license) in accordance with 'Licensing' Application Guidance set forth in IFRS 15;

(ii) Identifying the performance obligations comprised in the contract;

(iii) Estimating probability for (pre-)clinical development or commercial milestone achievement;

(iv) Determining the agreed variable considerations to be included in the transaction price taking into account the constraining limit of the "highly probable" criteria;

(v) Allocating the transaction price according to the stand-alone selling price of each of the performance obligations; and

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(vi) Estimating the finance component in the transaction price, based on the contract expected duration and discount rate.

Management makes its judgment taking into account all information available about clinical status of the underlying projects at the reporting date and the legal analysis of each applicable contracts. Further details are contained in note 25.

Recoverable Cash Advances received from the Walloon Region

As explained in note 3, accounting for RCAs requires initial recognition of the fair value of the loan received to determine the benefit of the below-market rate of interest, which shall be measured as the difference between the initial carrying value of the loan and the proceeds received. Loans granted to entities in their early stages of operations, for which there is significant uncertainty about whether any income will ultimately be generated and for which any income which will be generated will not arise until a number of years in the future, normally have high interest rates. Judgment is required to determine a rate which may apply to a loan granted on an open market basis and to determine projected revenue that will derive in the future from the products that benefited from the support of the Walloon Region. The estimated projected revenue by management is similar to the ones used for impairment of non-financial assets (see note 7).

In accordance with the RCA agreements, the following two components are assessed when calculating estimated future cash flows:

• 30% of the initial RCA, which is repayable when the Group exploits the outcome of the research financed; and

• A remaining amount, which is repayable based on a royalty percentage of future sales milestones, up to a level of 170% of the initial granted amount.

After initial recognition, RCA liabilities are measured at amortized cost using the cumulative catch up method requiring management to regularly revise its estimates of payments and to adjust the carrying amount of the financial liability to reflect actual and revised estimated cash flows.

Measurement and impairment of non-financial assets

With the exception of goodwill and certain intangible assets for which an annual impairment test is required, the Group is required to conduct impairment tests where there is an indication of impairment of an asset. Measuring the fair value of non-financial assets requires judgement and estimates by management. These estimates could change substantially over time as new facts emerge or new strategies are taken by the Group. Further details (including sensitivity analysis) are contained in note 7.

Contingent consideration provisions

The Group recorded a liability for the estimated fair value of contingent consideration arising from business combinations. The estimated amounts are the expected payments and timing of such payments, determined by considering the possible scenarios of forecast sales and other performance criteria, the amount to be paid under each scenario, and the probability of each scenario, which is then discounted to a net present value. The estimates could change substantially over time as new facts emerge and each scenario develops. Further details on management's estimations and sensitivity analysis are contained in note 23.

Discontinued operations

In September 2022, the Group's Manufacturing Business Unit was sold to Cellistic (see note 1). The Group does not present the expenses associated to the Manufacturing Business Unit under discontinued operations within the the consolidated statements of comprehensive income as this business unit was not considered a major line of business for the Group. In reaching this assessment, management had to apply judgment to determine if the Manufacturing Business Unit is major line of business, which included consideration of the size and role of this manufacturing unit. In the previous years, the Group focused its activities on the development of allogenic programs which decreased the manufacturing facilities requirements compared to autologous programs making the business less essential for the Group.

Onerous Contract & Invoice to receive accruals

As of December 31, 2022, the Group recorded a provision for onerous contracts for a total amount of €2.2 million in order to cover the contractual obligations, mainly on clinical activities follow-up and studies closing costs, after the Group's decision, in the fourth quarter of 2022, to discontinue the development of its remaining clinical programs CYAD-02, CYAD-101 and CYAD-211 (see notes 21 and 22)

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The Group also recognized expenses under comprehensive income statement through accruals for invoices to receive based on estimated amounts of rendered services or delivered goods during the year 2022 but not yet invoiced as per December 31, 2022 (see note 22).

The Group makes these estimates based on the input from the management and communication with the vendors.

NOTE 6: OPERATING SEGMENT INFORMATION

The chief operating decision-maker (CODM), who is responsible for making strategic decisions, allocating resources and assessing performance of the Group, has been identified as the Board of Directors.

Since the acquisition of the oncological platform in 2015, the management and the CODM have determined that there are two operating segments, being:

• the immuno-oncology segment regrouping all assets developed based on the CAR-T cell platform; and

• the cardiology segment, regrouping the Cardiopoiesis platform, C-Cath ez .

Corporate segment includes costs for general and administration functions not allocated to the other business segments.

Although the Group is currently active in Europe and in the US, no geographical financial information is currently available given the fact that the core operations are currently still in a study phase. No disaggregated information on product level or geographical level or any other level currently exists and hence also not considered by the Board of Directors for assessing performance or allocating resources.

The CODM does not review assets by segments, hence no segment information per assets is disclosed. As of December 31, 2022, the main Group's non-current assets are located in Belgium.

Since 2017, the Group is fully focused on the development of its immuno-oncology platform. Therefore, for the year ended December 31, 2022, most of the R&D expenses were incurred in the immuno-oncology segment, in line with prior years.

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| | | | | |
|:---|:---|:---|:---|:---|
| €'000 | For the year ended December 31, 2020 | For the year ended December 31, 2020 | For the year ended December 31, 2020 | For the year ended December 31, 2020 |
|  | Cardiology | Immuno-oncology | Corporate | Group Total |
| Revenue recognized at a point in time | 5 |  |  | 5 |
| Revenue recognized over time |  |  |  |  |
| Total Revenue | 5 |  |  | 5 |
| Cost of Sales |  |  |  |  |
| Gross Profit | 5 |  |  | 5 |
| Research & Development expenses | (124) | (21 398) |  | (21 522) |
| General & Administrative expenses |  |  | (9 315) | (9 315) |
| Change in fair value of contingent consideration |  | 9 228 |  | 9 228 |
| Net Other income/(expenses) | (2) | 4 582 | 38 | 4 617 |
| Operating Profit/(Loss) | (121) | (7 589) | (9 277) | (16 987) |
| Net financial income/(expenses) | (33) | (182) | (3) | (217) |
| Profit/(Loss) before taxes | (154) | (7 771) | (9 280) | (17 204) |
| Income Taxes |  |  |  |  |
| Profit/(Loss) for the year 2020 | (154) | (7 771) | (9 280) | (17 204) |

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| | | | | |
|:---|:---|:---|:---|:---|
| €'000 | For the year ended December 31, 2021 | For the year ended December 31, 2021 | For the year ended December 31, 2021 | For the year ended December 31, 2021 |
|  | Cardiology | Immuno-oncology | Corporate | Group Total |
| Revenue recognized at a point in time |  |  |  |  |
| Revenue recognized over time |  |  |  |  |
| Total Revenue |  |  |  |  |
| Cost of Sales |  |  |  |  |
| Gross Profit |  |  |  |  |
| Research & Development expenses | (142) | (20 631) |  | (20 773) |
| General & Administrative expenses |  |  | (9 908) | (9 908) |
| Change in fair value of contingent consideration |  | 847 |  | 847 |
| Net Other income/(expenses) | (108) | 3 507 | 44 | 3 443 |
| Operating Profit/(Loss) | (250) | (16 277) | (9 864) | (26 391) |
| Net financial income/(expenses) | 107 | (165) | (53) | (111) |
| Profit/(Loss) before taxes | (143) | (16 442) | (9 917) | (26 502) |
| Income Taxes |  |  | (10) | (10) |
| Profit/(Loss) for the year 2021 | (143) | (16 442) | (9 927) | (26 512) |

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| | | | | |
|:---|:---|:---|:---|:---|
| €'000 | For the year ended December 31, 2022 | For the year ended December 31, 2022 | For the year ended December 31, 2022 | For the year ended December 31, 2022 |
|  | Cardiology | Immuno-oncology | Corporate | Group Total |
| Revenue recognized at a point in time |  |  |  |  |
| Revenue recognized over time |  |  |  |  |
| Total Revenue |  |  |  |  |
| Cost of Sales |  |  |  |  |
| Gross Profit |  |  |  |  |
| Research & Development expenses | (587) | (18 341) |  | (18 928) |
| General & Administrative expenses |  |  | (10 546) | (10 546) |
| Change in fair value of contingent consideration |  | 14 679 |  | 14 679 |
| Impairment of Oncology intangible assets |  | (35 084) |  | (35 084) |
| Net Other income/(expenses) | (63) | 9 148 | (63) | 9 022 |
| Operating Profit/(Loss) | (650) | (29 598) | (10 609) | (40 857) |
| Net financial income/(expenses) | (19) | (132) | 138 | (13) |
| Profit/(Loss) before taxes | (669) | (29 730) | (10 471) | (40 870) |
| Income Taxes |  | (65) |  | (65) |
| Profit/(Loss) for the year 2022 | (669) | (29 795) | (10 471) | (40 935) |

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#### NOTE 7: INTANGIBLE ASSETS
The change in intangible assets is broken down as follows, per class of assets:

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| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| (€'000) | Goodwill | In-process<br> research and<br> development | Development<br> costs | Patents,<br> licenses,<br> trademarks | Software | Total |
| Capitalized costs |  |  |  |  |  |  |
| At January 1, 2021 | 883 | 33 678 | 1 084 | 13 071 | 279 | 48 995 |
| Additions |  |  |  | 214 |  | 214 |
| Divestiture |  |  |  |  | (16) | (16) |
| At December 31, 2021 | 883 | 33 678 | 1 084 | 13 285 | 263 | 49 193 |
| Additions |  |  |  | 876 |  | 876 |
| Divestiture | (239) |  |  | (213) | (165) | (617) |
| At December 31, 2022 | 644 | 33 678 | 1 084 | 13 948 | 98 | 49 452 |
| Accumulated amortization | Accumulated amortization |  |  |  |  |  |
| At January 1, 2021 |  |  | (543) | (12 052) | (229) | (12 527) |
| Amortization charge |  |  | (67) | (134) | (16) | (217) |
| Divestiture |  |  |  |  | 16 | 16 |
| At December 31, 2021 |  |  | (610) | (12 186) | (229) | (13 025) |
| Amortization charge |  |  | (66) | (547) |  | (613) |
| Divestiture |  |  |  | 3 | 131 | 134 |
| Impairment | (644) | (33 678) |  | (762) |  | (35 084) |
| At December 31, 2022 | (644) | (33 678) | (676) | (13 492) | (98) | (48 588) |
| Net book value |  |  |  |  |  |  |
| Capitalized costs | 883 | 33 678 | 1 084 | 13 285 | 263 | 49 193 |
| Accumulated amortization |  |  | (610) | (12 186) | (229) | (13 025) |
| At December 31, 2021 | 883 | 33 678 | 474 | 1 099 | 34 | 36 168 |
| Capitalized costs | 644 | 33 678 | 1 084 | 13 948 | 98 | 49 452 |
| Accumulated amortization | (644) | (33 678) | (676) | (13 492) | (98) | (48 588) |
| At December 31, 2022 |  |  | 408 | 456 |  | 864 |

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Goodwill and IPR&D resulted from the purchase price allocation exercise performed for the acquisition of Oncyte LLC in 2015. As of December 31, 2022, and 2021, Goodwill and IPR&D are not amortized but tested for impairment.

The capitalized development costs relate to the development of C-Cathez. The development costs of C-Cathez were capitalized in May 2012 and are being amortized until 2029. No other development costs have been capitalized to date. All other programs' (C-Cure, CYAD-01, CYAD-02, CYAD-101, CYAD-211…) related development costs have been assessed as not being eligible for capitalization and have therefore been recognized in the income statement as research and development expenses. Software is amortized over a period of 3 to 5 years.

Patents, licenses and trademarks, mainly relate to the following items:

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#### **Table of Contents**

• Exclusive Agreement for Horizon Discovery's shRNA Platform to develop next-generation allogenic CAR T Therapies acquired for €0.9 million at the end of December 2018. Since acquisition, the Company capitalized milestone payments for a total amount o f €0.3 million. This patent is being amortized over the remaining intellectual property protection of 20 years, with the first patent application filed in 2008 ;

• An intangible asset has been capitalized in January 2022 for $1.0 million (€0.9 million), reflecting the Group's opportunity to explore new partnership for the C-Cathez, which is being amortized over a period of 2 years (see note 5.8); and

• During the course of 2022, two exclusive licenses agreements have been terminated resulting in disposal of € 0. 3 million of intangible assets.

Impairment testing

Impairment testing is detailed below.

Immuno-oncology CGU impairment test<sup>3</sup>

Goodwill and IPR&D exclusively relate to the acquisition of the former entity Oncyte LLC (meanwhile liquidated into Celyad SA) which was acquired in 2015. Management performs an annual impairment test on goodwill and on 'indefinite lived assets' that are not amortized in accordance with the accounting policies stated in note 3. The impairment test has been performed at the level of the immuno-oncology segment corresponding to the CGU to which the goodwill and the IPR&D belong as well as the Horizon Discovery's shRNA platform. The recoverable amount associated to this CGU is calculated based on the fair value less costs to sell model using Level 3 fair value measurements for which the Group developed unobservable inputs and requires the use of assumptions.

In October 2022, the Group announced its new business strategy "Celyad 2.0" (see note 1), under which the Company has decided to discontinue the development of its remaining clinical programs, shifting from an organization focused on clinical development to one prioritizing R&D discovery and the monetization of its IP portfolio through partnerships, collaborations and license agreements. Therefore, the cash flow projections based on the previous business plan became obsolete.

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| | |
|:---|:---|
| 3 | The uncertainly raised by the COVID-19 pandemic and the war in Ukraine is not impacting impairment testing. Although there are lot of uncertainties, it does not impact the Group's assets valuation as of December 31, 2022. For additional information on COVID-19 pandemic and war in Ukraine updates, refer to note 2.  |

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Consequently, as of December 31, 2022, Management built a new business plan and related cash flow projections based on projected sublicense income associated with its patents around allogeneic CAR T-cell therapies and NKG2D-based therapies.

The accounting standard IAS 38 impose that projected future cash inflow of economic benefits used for the valuation of a recoverable amount associated to a CGU cannot be remote. Due to the early stage of the implementation of the Celyad 2.0 strategy and the fact no firm sublicence contract nor collaboration contract was concluded as of December 31, 2022, Management had to recognize that significant uncertainty exist on the timing and amount of the new strategy outcomes and therefore had to conclude that the possibility of any inflow, as of December 31, 2022, was remote regarding accounting standards definition. Therefore, Management recognized a full impairment loss on the remaining value of the goodwill, IPR&D and Horizon Discovery's shRNA platform. This accounting conclusion, which reflects a picture of the situation at December 31, 2022, does not affect Management's commitment to continue the exploitation of these IPs in its new Celyad 2.0 strategy.

As soon as a future event (such as a firm sublicense or collaboration contract) will increase the probability of revenue, indicating that the probability is more than remote and consequently that the recognized impairment losses may no longer exist or may have decreased, the Group will estimate the cash-generating unit's recoverable amount.. The reversal will be limited so that the carrying amount of the asset does not exceed its recoverable amount. An impairment loss recognized on goodwill is however not reversed in a subsequent period.

For comparative purpose, as of December 31, 2021, the calculations used cash flow projections based on a business plan ending in 2040 based on probability of success of CYAD-02, CYAD-101 and CYAD-211 product candidates as well as extrapolations of projected cash flows resulting from the future expected sales on CYAD-101 and CYAD-211 and sublicense income associated with CYAD-02. The CGU's recoverable value, determined accordingly, exceeded its carrying amount. Accordingly, no impairment loss was recognized either on goodwill, IPR&D, the Horizon Discovery's shRNA platform or other immuno-oncology licenses at December 31, 2021.

As of December 31, 2021, Management's key assumptions (assumptions to which the unit's or group of units', recoverable amount is most sensitive) about projected cash flows when determining fair value less costs to sell were as follows:

• Discount rate (WACC)

Management had estimated the discount rate (WACC) as of December 31, 2021, to be 13.4% based on following components: the US Government Treasury bill 20-Y, the Group's Beta, the equity Market Risk Premium and the small firm/illiquidity premium. The decrease of the WACC was mainly driven by a decrease of the Beta of the Group which is associated with the volatility of the Group's equity influenced by its ongoing clinical programs and overall competitive landscape within the immuno-oncology field. Management corroborates its estimation with industry standards for biotechnology companies, the WACC used by Equity Research companies following the Group and transactions that had been sourced by the Group over the past 24 months.

• Projected Revenue

Management had estimated the projected revenue (using cash flow projections ending in 2040) based on the following components: total market and market share, time-to-market, treatment price and terminal value. Management based its estimation of projected revenue and related components with the Group's business plan, industry data for biotechnology companies, evolution of similar R&D programs, comparable prices, expected patent expiration period. The weight of this assumption is partially alleviated by the probability of success (PoS) presented hereunder.

• Probabilities of Success (PoS)

Management had estimated the PoS based on Clinical Development Success Rates observed by independent business intelligence consulting companies for hematological and solid tumor diseases. Probability of the Group's product candidates reaching the market used had been updated compared to prior year-end based on most recent Clinical Development Success Rates observed by independent business intelligence consulting companies for hematological and solid tumor diseases as follows:

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| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| PoS | Phase I | Phase I to Phase<br> II | Phase II to Phase<br> III | Phase III to BLA | BLA to Approval | Cumulative PoS |
| CYAD-02 | 100% | 50% | 28% | 60% | 90% | 7.5% |
| CYAD-101 | 100% | 49% | 23% | 43% | 93% | 4.6% |
| CYAD-211 | 100% | 50% | 28% | 60% | 90% | 7.5% |

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The Group's updated PoS rates for its clinical programs as of December 31, 2021, incorporates data for clinical development success rates from 2011 – 2020, which the Group believes is a more accurate reflection of clinical development success rates across stage of development and in aggregate.

NOTE 8: PROPERTY, PLANT AND EQUIPMENT

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| | | | | | |
|:---|:---|:---|:---|:---|:---|
| (€'000) | Property | Equipment | Furniture | Leasehold | Total |
| Capitalized costs |  |  |  |  |  |
| At January 1, 2021 | 3 001 | 3 563 | 250 | 4 032 | 10 846 |
| Additions | 24 | 388 |  | 10 | 422 |
| Disposals |  | (192) |  |  | (192) |
| Currency translation adjustments |  | 1 |  | 15 | 16 |
| At December 31, 2021 | 3 025 | 3 760 | 250 | 4 057 | 11 092 |
| Additions | 146 | 116 | 15 |  | 277 |
| Disposals | (3 171) | (2 180) | (45) | (2 903) | (8 299) |
| Currency translation adjustments |  | 1 |  | 11 | 12 |
| Transfers to Assets held for sale |  | (421) | (220) | (989) | (1 630) |
| At December 31, 2022 |  | 1 276 |  | 176 | 1 452 |
| Accumulated depreciation: | Accumulated depreciation: | Accumulated depreciation: | Accumulated depreciation: | Accumulated depreciation: | Accumulated depreciation: |
| At January 1, 2021 | (827) | (2 625) | (214) | (3 061) | (6 727) |
| Depreciation charge | (454) | (512) | (24) | (313) | (1 303) |
| Disposals |  | 191 |  |  | 191 |
| Currency translation adjustments |  | (2) |  | (3) | (5) |
| At December 31, 2021 | (1 281) | (2 948) | (238) | (3 377) | (7 844) |
| Depreciation charge | (439) | (268) |  | (120) | (827) |
| Disposals | 1 720 | 1 834 | 18 | 2 575 | 6 147 |
| Currency translation adjustments |  |  |  | (5) | (5) |
| Transfers to Assets held for sale |  | 414 | 220 | 751 | 1 385 |
| At December 31, 2022 |  | (968) |  | (176) | (1 144) |
| Net book value |  |  |  |  |  |
| Capitalized costs | 3 025 | 3 760 | 250 | 4 057 | 11 092 |
| Accumulated depreciation | (1 281) | (2 948) | (238) | (3 377) | (7 844) |
| At December 31, 2021 | 1 744 | 812 | 12 | 680 | 3 248 |
| Capitalized costs |  | 1 276 |  | 176 | 1 452 |
| Accumulated depreciation |  | (968) |  | (176) | (1 144) |
| At December 31, 2022 |  | 309 |  |  | 309 |

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Property, Plant and Equipment is mainly composed of right-of-use on leased offices, facilities and equipment (including vehicles), office furniture, leasehold improvements, and laboratory equipment.

In September 2022, the six-year lease agreement of the U.S. corporate offices located in Boston, Massachusetts ended which also resulted in recording loss of approximately €0.1 million related to leasehold improvement.

In September 2022, the Company's Manufacturing Business Unit based in Belin 12 building in Mont-Saint-Guibert, Belgium, was sold to Cellistic for a total consideration of €6.0 million (see note 5.1). The Manufacturing Business Unit included facilities and equipment, office furniture, leasehold improvements, and laboratory equipment. The book value of assets sold was approximately €0.8 million (including related goodwill).

Consequent to the sale of the Manufacturing Business Unit, the lease on the related offices was terminated, resulting in the write-off of the right-of-use asset and related capitalized assets of approximately €0.6 million and €0.9 million, respectively.

#### NOTE 9: NON-CURRENT TRADE RECEIVABLES AND OTHER NON-CURRENT ASSETS

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| | | |
|:---|:---|:---|
| (€'000) | As at December 31, | As at December 31, |
|  | 2022 | 2021 |
| Non-current trade receivables Mesoblast license agreement |  | 2 209 |
| Total Non-current Trade and Other receivables |  | 2 209 |

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In May 2018, the Group entered into an exclusive license agreement with Mesoblast, an Australian biotechnology company, to develop and commercialize our intellectual property rights relating to C-Cathez, an intra-myocardial injection catheter. This license agreement refers to the right to use the company's intellectual property as it exists at the point in time the license has been granted (May 2018) and foresees contingent milestone payments. The related receivable is reported for its discounted value (€2.2 million) under 'Non-current trade receivables'. There were no corresponding contract liabilities reported at December 31, 2021, as no performance obligation was outstanding.

On January 17, 2022, the Group entered into an amendment with Mesoblast to convert the license into non-exclusive whereby the Company agreed, (a) to settle $2.5 million (€2.2 million) of receivable as of December 31, 2021, with $1.5 million and; (b) extend certain milestone payments. The consideration of $1.5 million was agreed to be paid by Mesoblast in Mesoblast ordinary shares. The difference of $1.0 million (€0.9 million) has been capitalized as an intangible asset reflecting the Group's opportunity to explore new partnership for the C-Cathez (see note 7).

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#### **Table of Contents**

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| | | |
|:---|:---|:---|
| (€'000) | As at December 31, | As at December 31, |
|  | 2022 | 2021 |
| R&D Tax credit receivable | 3 454 | 3 764 |
| Total Non-current Grant receivables | 3 454 | 3 764 |
| Deposits | 264 | 262 |
| Total Other non-current assets | 264 | 262 |

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In 2017, the Group recognized for the first time a R&D tax credit (€1.2 million) receivable from the Federal Government that included a one-time catch-up effect. Since 2018, further R&D tax credit receivables are recorded on an annual basis. For the year ended December 31, 2022, the Group recorded an additional R&D tax credit of €0.5 million, taking into account all information available as of December 31, 2022. During the year ended December 31, 2022, the Group received €0.8 million related to the fiscal year 2017 R&D tax credit. Based on facts and circumstances, the Group believes that all the receivables and/or financial fixed assets are recoverable and thus, the Group estimates that no reserve is required.

The non-current assets relate to security deposits paid to the lessors of the building leased by the Group and a deposit to the Social Security administration.

NOTE 10: INVENTORIES AND WORK IN PROGRESS

Not applicable.

NOTE 11: TRADE, OTHER RECEIVABLES AND OTHER ASSETS

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| | | |
|:---|:---|:---|
| (€'000) | As at December 31, | As at December 31, |
|  | 2022 | 2021 |
| Trade receivables | 909 | 203 |
| Advance deposits | 209 | 246 |
| Net Investment in Lease |  | 219 |
| Total Trade and Other receivables | 1 118 | 668 |
| Current Grant receivables (RCAs) |  | 1 121 |
| Current Grant receivables (Others) |  | 274 |
| Total Current Grant receivables |  | 1 395 |
| Prepaid expenses | 667 | 1 688 |
| VAT receivable | 316 | 483 |
| Income and other tax receivables | 34 | 40 |
| Total Other current assets | 1 017 | 2 211 |
| Total Trade receivables, advances and other current assets | 2 135 | 4 274 |

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The increase of trade receivables is mainly due to credit notes to be received following the closing of clinical studies for an amount of €0.3 million and an amount of €0.2 million related to the sales of the C-Cathez, which is also reflected in other current liabilities through recognition of deferred revenue on sales for the same amount (see note 22).

At December 31, 2021, the current net investment in lease related to the receivable recorded under subleases. The lease has ended in September 2022, such as the balance as of December 31, 2022 is equal to zero.

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As of December 31, 2022, all grant receivables from the Walloon Region have been paid.

The decrease in other current assets as of December 31, 2022 compared to December 31, 2021 of €1.2 million is mainly driven by the timing of payments on insurances contracts and buildings rents combined with the reversal of transaction costs for an amount of €0.6 million mainly linked to the LPC equity facility not subject to further capitalization and not available to be offset against a future capital raise as the equity facility expired early January 2023. In addition, the VAT receivable decreased along with clinical expenses as a result of decreased clinical activities at year-end.

NOTE 12: SHORT-TERM INVESTMENT

Given the level of market interest rates for corporate deposits of short-term maturities, the Group has not invested in short-term deposits over the years 2022 and 2021.

NOTE 13: CASH AND CASH EQUIVALENTS

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| | | |
|:---|:---|:---|
| (€'000) | As at December 31, | As at December 31, |
|  | 2022 | 2021 |
| Cash at bank and on hand | 12 445 | 30 018 |
| Total | 12 445 | 30 018 |

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The Group's cash and cash equivalents amounted to €12.4 million at December 31, 2022 which accounts for a decrease of €17.6 million as compared to year-end 2021, mainly as a result of the Group's operations expenses partly compensated by cash proceeds from the sale of CTMU activities, sales of short-term investments resulting from the Mesoblast amendment signed in January 2022, and cash proceeds from recoverable cash advances (RCAs) and other grants received from the Walloon Region .

Cash at banks earn interest at floating rates based on daily bank deposit rates. For the years ended December 31, 2022 and 2021, the earned bank interests have been insignificant.

NOTE 14: INVESTMENT IN SUBSIDIARIES

The consolidation scope of the Group is as follows, for both current and comparative years presented in these year-end financial statements:

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| | | | | | |
|:---|:---|:---|:---|:---|:---|
| Name | Country of<br> Incorporation<br> and Place of<br> Business | Nature of<br> Business | Proportion of<br> ordinary<br> shares directly<br> held by parent<br> (%) | Proportion of<br> ordinary shares<br> held by the<br> Group (%) | Proportion of<br> ordinary<br> shares held by<br> non-controlling<br> interests (%) |
| Name | Country of<br> Incorporation<br> and Place of<br> Business | Nature of<br> Business | Proportion of<br> ordinary<br> shares directly<br> held by parent<br> (%) | Proportion of<br> ordinary shares<br> held by the<br> Group (%) | Proportion of<br> ordinary<br> shares held by<br> non-controlling<br> interests (%) |
| Name | Country of<br> Incorporation<br> and Place of<br> Business | Nature of<br> Business | Proportion of<br> ordinary<br> shares directly<br> held by parent<br> (%) | Proportion of<br> ordinary shares<br> held by the<br> Group (%) | Proportion of<br> ordinary<br> shares held by<br> non-controlling<br> interests (%) |
| Celyad SA | BE | Biopharma | Parent company |  |  |
| Celyad Inc | US | Biopharma | 100% | 100% | 0% |
| CorQuest Medical Inc | US | Medical Device | 100% | 100% | 0% |
| Biological Manufacturing Services SA | BE | Manufacturing | 100% | 100% | 0% |

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Biological Manufacturing Services SA (BMS) was acquired in May 2016. BMS owned Good Manufacturing Practices ('GMP') laboratories until end of September 2022 after the sale of the Group's Good Manufacturing Practice (GMP) grade cell therapy manufacturing facility to Cellistic.

NOTE 15: SHARE CAPITAL

The number of shares issued is expressed in units.

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| | | |
|:---|:---|:---|
|  | As at December 31, | As at December 31, |
|  | 2022 | 2021 |
| Total number of issued and outstanding shares | 22 593 956 | 22 593 956 |
| Total share capital (€'000) | 78 585 | 78 585 |

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As of December 31, 2022 and 2021, the share capital amounted to €78.585 million represented by 22,593,956 fully authorized, subscribed and paid-up shares with a nominal value of €3.48 per share. This number does not include warrants issued by the Group and granted to certain directors, employees and non-employees of the Group.

As of December 31, 2022, total number of authorized shares remains available for issuance are 1,361,242, out of which, 323,700 number of shares are reserved under share based compensation plan.

History of the capital of the Company

The Company was incorporated on July 24, 2007 with a share capital of €62,500 by the issuance of 409,375 class A shares. On August 31, 2007, the Company has issued 261,732 class A shares to Mayo Clinic by way of a contribution in kind of the upfront fee that was due upon execution of the Mayo License for a total amount of €9,500,000.

Round B Investors participated in a capital increase of the Company by way of a contribution in kind of a convertible loan (€2,387,049) and a contribution in cash (€4,849,624 of which €1,949,624 was uncalled) on December 23, 2008; 204,652 class B shares were issued at the occasion of that capital increase. Since then, the capital is divided in 875,759 shares, of which 671,107 are class A shares and 204,652 are class B shares.

On October 29, 2010, the Company closed its third financing round resulting in a capital increase totaling €12,100,809. The capital increase can be detailed as follows:

• capital increase in cash by certain existing investors for a total amount of €2,609,320.48 by the issuance of 73,793 class B shares at a price of €35.36 per share;

• capital increase in cash by certain existing investors for a total amount of €471,240 by the issuance of 21,000 class B shares at a price of €22.44 per share;

• capital increase in cash by certain new investors for a total amount of €399,921.60 by the issuance of 9,048 class B shares at a price of €44.20 per share;

• exercise of 12,300 warrants ("Warrants A") granted to the Round C investors with total proceeds of €276,012 and issuance of 12,300 class B shares. The exercise price was €22.44 per Warrant A;

• contribution in kind by means of conversion of the loan C for a total amount of €3,255,524.48 (accrued interest included) by the issuance of 92,068 class B shares at a conversion price of €35.36 per share;

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• contribution in kind by means of conversion of the loan D for a total amount of €2,018,879.20 (accrued interest included) by the issuance of 57,095 class B shares at a conversion price of €35.36 per share. The loan D is a convertible loan granted by certain investors to the Company on 14 October 2010 for a nominal amount of €2,010,000.

• contribution in kind of a payable towards Mayo Foundation for Medical Education and Research for a total amount of €3,069,911 by the issuance of 69,455 class B shares at a price of €44.20 per share. The payable towards Mayo Clinic was related to (i) research undertaken by Mayo Clinic in the years 2009 and 2010, (ii) delivery of certain materials, (iii) expansion of the Mayo Clinical Technology License Contract by way the Second Amendment dated October 18, 2010.

On May 5, 2011, pursuant the decision of the Extraordinary General Meeting, the capital was reduced by an amount of €18,925,474 equivalent to the outstanding net loss as of December 31, 2010.

On May 31, 2013, the Company closed its fourth financing round, the 'Round D financing'. The convertible loans E, F, G and H previously recorded as financial debt were converted in shares which led to an increase in equity for a total amount of €28,645k of which €5,026k is accounted for as capital and € 6,988k as share premium. The remainder (€ 16,631k) is accounted for as other reserves on fully settled contribution in kind convertible loans. Furthermore, a contribution in cash by existing shareholders of the Company led to an increase in share capital and issue premium by an amount of €7,000k.

At the Extraordinary Shareholders Meeting of June 11, 2013 all existing classes of shares of the Company have been converted into ordinary shares. Preferred shares have been converted at a 1 for 1 ratio.

On July 5, 2013, the Company completed its Initial Public Offering. The Company issued 1,381,500 new shares at €16.65 per shares, corresponding to a total of €23,002k.

On July 15, 2013, the over-allotment option was fully exercised for a total amount of €3,450k corresponding to 207,225 new shares. The total IPO proceeds amounted to €26,452k and the capital and the share premium of the Company increased accordingly. The costs relating to the capital increases performed in 2013 amounted to €2.8 million and are presented as a deduction of share premium.

On June 11, 2013, the Extraordinary General Shareholders' Meeting of Celyad SA authorized the Board of Directors to increase the share capital of the Company, in one or several times, and under certain conditions set forth in extenso in the articles of association. This authorization is valid for a period of five years starting on July 26, 2013 and until July 26, 2018. The Board of Directors may increase the share capital of the Company within the framework of the authorized capital for an amount of up to €21,413k.

Over the course of 2014, the capital of the Company was increased in June 2014 by way of a capital increase of €25,000k represented by 568,180 new shares fully subscribed by Medisun International Limited.

In 2014, the capital of the Company was also increased by way of exercise of Company warrants. Over four different exercise periods, 139,415 warrants were exercised resulting in the issuance of 139,415 new shares. The capital and the share premium of the Company were therefore increased respectively by €488k and €500k.

In January 2015, the shares of Oncyte LLC were contributed to the capital of the Company, resulting in a capital increase of €3,452k and the issuance of 93,087 new shares.

In 2015, the Company conducted two fund raisings. A private placement was closed in March resulting in a capital increase of €31,745k represented by 713,380 new shares. The Company also completed an IPO on Nasdaq in June, resulting in a capital increase of €87,965k represented by 1,460,000 new shares.

Also, in 2015, the capital of the Company was also increased by way of exercise of Company warrants. Over three different exercise periods, 6,749 warrants were exercised resulting in the issuance of 6,749 new shares. The capital and the share premium of the Company were therefore increased respectively by €23k and €196k.

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Over 2017 the capital of the Company was also increased by way of exercise of Company warrants. Over four different exercise periods, 225,966 warrants were exercised resulting in the issuance of 225,966 new shares. The capital of the Company was therefore increased by €625k.

In August 2017, pursuant to the amendment of the agreements with Celdara Medical LLC and Dartmouth College, the CAR T technology inventors, the capital of the Company was increased by way of contribution in kind of a liability owed to Celdara Medical LLC. 328,275 new shares were issued at a price of €32.35 (being Celyad share's average market price for the 30 days preceding the transaction) and the capital and the share premium of the Company were therefore increased respectively by €1,141k and €9,479k without an impact on the cash and cash equivalents, explaining why such transaction is not disclosed in the consolidated statements of cash flows.

In May 2018, the Company completed a global offering of $54.4 million (€46.1 million), resulting in cash proceeds for an amount of €43.0 million net of bank fees and transaction costs.

In May 2019, share premium decreased as a result of the absorption of accounting losses for an amount of €172.3 million, with a counterpart in the financial statements line item 'Accumulated Deficit'. The absorption of the accumulated deficit into share premium is a non-cash accounting transaction.

In September 2019, the Company completed a global offering of $20.0 million (€18.2 million), resulting in cash proceeds for an amount of €16.4 million net of bank fees and transaction costs.

On January 8, 2021, the Company has entered into a committed equity purchase agreement ("Purchase Agreement") for up to $40.0 million with Lincoln Park Capital Fund, LLC ("LPC"), a Chicago-based institutional investor. Over the 24-month term of the Purchase Agreement, the Company will have the right to direct LPC to purchase up to an aggregate amount of $40.0 million American Depositary Shares ("ADSs"), each of which represents one ordinary share of the Company. From the inception of the Purchase Agreement through December 31, 2021, a total of 1,962,812 new shares have been issued by the Company and subscribed by LPC for a cash proceed of €9.2 million. As of December 31, 2022, there was a remaining access to the Purchase Agreement established with LPC for an amount of $28.0 million. The Purchase Agreement expired early January 2023.

During the extraordinary shareholders meeting of May, 25 2021, the shareholders, in accordance with Belgian Company Law, approved the absorption of approximately €43.3 million of accounting losses into share premium. As a result, share premium has been reduced by a cumulative amount of €43.3 million in the 12 months period ended December 31, 2021 (€234.6 million of loss absorption has been approved and recorded from inception to December 31, 2022, as no such loss absorption occurred in 2022) against capital reduction reserve. This transaction has no impact on the total equity, comprehensive income (loss), assets (including cash) nor liabilities.

On May, 21 2021 and June 14, 2021, a total of 188,800 new shares have been issued by the Company and subscribed by Jefferies under the ATM for a cash proceed of €0.9 million.

On December 8, 2021, 6,500,000 new shares were issued by decision of the board of directors and subscribed for by CFIP CLYD LLC in the framework of a private placement for a global cash proceed of €28.9 million.

As of December 31, 2022, all shares issued have been fully paid.

The following share issuances occurred since the incorporation of the Company:

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| | | | | |
|:---|:---|:---|:---|:---|
| Category | Transaction date | Description | # of shares | Par<br> value<br> (in €) |
| Class A shares | 24 July 2007 | Company incorporation | 409 375 | 0.15 |
| Class A shares | 31 August 2007 | Contribution in kind (upfront fee Mayo License) | 261 732 | 36.30 |
| Class B shares | 23 December 2008 | Capital increase (Round B) | 137 150 | 35.36 |
| Class B shares | 23 December 2008 | Contribution in kind (Loan B) | 67 502 | 35.36 |
| Class B shares | 28 October 2010 | Contribution in cash | 21 000 | 22.44 |
| Class B shares | 28 October 2010 | Contribution in kind (Loan C) | 92 068 | 35.36 |
| Class B shares | 28 October 2010 | Contribution in kind (Loan D) | 57 095 | 35.36 |
| Class B shares | 28 October 2010 | Contribution in cash | 73 793 | 35.36 |
| Class B shares | 28 October 2010 | Exercise of warrants | 12 300 | 22.44 |
| Class B shares | 28 October 2010 | Contribution in kind (Mayo receivable) | 69 455 | 44.20 |
| Class B shares | 28 October 2010 | Contribution in cash | 9 048 | 44.20 |
| Class B shares | 31 May 2013 | Contribution in kind (Loan E) | 118 365 | 38.39 |
| Class B shares | 31 May 2013 | Contribution in kind (Loan F) | 56 936 | 38.39 |
| Class B shares | 31 May 2013 | Contribution in kind (Loan G) | 654 301 | 4.52 |
| Class B shares | 31 May 2013 | Contribution in kind (Loan H) | 75 755 | 30.71 |
| Class B shares | 31 May 2013 | Contribution in cash | 219 016 | 31.96 |
| Class B shares | 4 June 2013 | Conversion of warrants | 2 409 176 | 0.01 |
| Ordinary shares | 11 June 2013 | Conversion of Class A and Class B shares in ordinary shares | 4 744 067 |  |
| Ordinary shares | 5 July 2013 | Initial Public Offering | 1 381 500 | 16.65 |
| Ordinary shares | 15 July 2013 | Exercise of over-allotment option | 207 225 | 16.65 |
| Ordinary shares | 31 January 2014 | Exercise of warrants issued in September 2008 | 5 966 | 22.44 |
| Ordinary shares | 31 January 2014 | Exercise of warrants issued in May 2010 | 333 | 22.44 |
| Ordinary shares | 31 January 2014 | Exercise of warrants issued in January 2013 | 120 000 | 4.52 |
| Ordinary shares | 30 April 2014 | Exercise of warrants issued in September 2008 | 2 366 | 22.44 |
| Ordinary shares | 16 June 2014 | Capital increase | 284 090 | 44.00 |
| Ordinary shares | 30 June 2014 | Capital increase | 284 090 | 44.00 |
| Ordinary shares | 4 August 2014 | Exercise of warrants issued in September 2008 | 5 000 | 22.44 |
| Ordinary shares | 4 August 2014 | Exercise of warrants issued in October 2010 | 750 | 35.36 |
| Ordinary shares | 3 November 2014 | Exercise of warrants issued in September 2008 | 5 000 | 22.44 |
| Ordinary shares | 21 January 2015 | Contribution in kind (Celdara Medical LLC) | 93 087 | 37.08 |
| Ordinary shares | 7 February 2015 | Exercise of warrant issued in May 2010 | 333 | 22.44 |
| Ordinary shares | 3 March 2015 | Capital increase | 713 380 | 44.50 |
| Ordinary shares | 11 May 2015 | Exercise of warrant issued in May 2010 | 500 | 22.44 |
| Ordinary shares | 24 June 2015 | Capital increase | 1 460 000 | 60.25 |
| Ordinary shares | 4 August 2015 | Exercise of warrant issued in May 2010 | 666 | 22.44 |
| Ordinary shares | 4 August 2015 | Exercise of warrant issued in October 2010 | 5 250 | 35.36 |
| Ordinary shares | 1 February 2017 | Exercise of warrant issued in May 2013 | 207 250 | 2.64 |
| Ordinary shares | 2 May 2017 | Exercise of warrant issued in May 2013 | 4 900 | 2.64 |
| Ordinary shares | 1 August 2017 | Exercise of warrant issued in May 2013 | 7 950 | 2.64 |
| Ordinary shares | 23 August 2017 | Contribution in kind (Celdara Medical LLC) | 328 275 | 32.35 |
| Ordinary shares | 9 November 2017 | Exercise of warrant issued in May 2013 | 5 000 | 2.64 |
| Ordinary shares | 9 November 2017 | Exercise of warrant issued in October 2010 | 866 | 35.36 |
| Ordinary shares | 7 February 2018 | Exercise of warrant issued in May 2013 | 4 500 | 2.64 |
| Ordinary shares | 22 May 2018 | Capital increase | 2 070 000 | 22.29 |
| Ordinary shares | 16 September 2019 | Capital increase | 2 000 000 | 9.08 |
| Ordinary shares | 8 January 2021 | Capital increase | 262 812 | 4.94 |
| Ordinary shares | 29 March 2021 | Capital increase | 200 000 | 6.19 |
| Ordinary shares | 9 April 2021 | Capital increase | 300 000 | 5.83 |
| Ordinary shares | 29 April 2021 | Capital increase | 300 000 | 5.23 |
| Ordinary shares | 21 May 2021 | Capital increase | 182 000 | 4.58 |
| Ordinary shares | 14 June 2021 | Capital increase | 6 800 | 4.98 |
| Ordinary shares | 28 June 2021 | Capital increase | 300 000 | 4.46 |
| Ordinary shares | 22 July 2021 | Capital increase | 300 000 | 3.46 |
| Ordinary shares | 20 October 2021 | Capital increase | 300 000 | 3.38 |
| Ordinary shares | 8 December 2021 | Capital increase | 6 500 000 | 4.44 |

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| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| (€000) |  |  |  |  |  |  |
| Nature of the transactions | Share<br> Capital | Share<br> premium | Capital<br> reduction<br> reserve | Other<br> reserves | Accumulated<br> Deficit | Number of<br> shares |
| Balance as at January 1, 2021 | 48 513 | 43 349 | 191 213 | 30 958 | (283 039) | 13 942 344 |
| Reduction of share premium by absorption of losses |  | (43 349) | 43 349 |  |  |  |
| Capital increase | 30 072 | 8 900 |  |  |  | 8 651 612 |
| Transaction costs associated with capital increases |  | (2 583) |  |  |  |  |
| Loss for the period |  |  |  |  | (26 512) |  |
| Share Based Payment |  |  |  | 2 172 |  |  |
| Currency Translation differences |  |  |  | 42 |  |  |
| Remeasurements of defined benefit obligation |  |  |  |  | 554 |  |
| Balance as at December 31, 2021 | 78 585 | 6 317 | 234 562 | 33 172 | (308 997) | 22 593 956 |
| Loss for the period |  |  |  |  | (40 935) |  |
| Share Based Payment |  |  |  | 1 624 |  |  |
| Currency Translation differences |  |  |  | 4 |  |  |
| Remeasurements of defined benefit obligation |  |  |  |  | (15) |  |
| Balance as at December 31, 2022 | 78 585 | 6 317 | 234 562 | 34 800 | (349 947) | 22 593 956 |

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The total number of shares issued and outstanding as of December 31, 2022, totals 22,593,956 ordinary common shares.

Capital reduction reserve

Pursuant to Belgian Companies and Associations Code, the calculation of amounts available for distribution to shareholders, as dividends or otherwise, must be determined on the basis of our standalone non-consolidated statutory financial statements of Celyad Oncology SA prepared under Belgian GAAP, and not on the basis of IFRS consolidated financial statements. In addition, under the CCA, the Company may declare or pay dividends only if, following the declaration and issuance of the dividends, the amount of the Company's net assets on the date of the closing of the last financial year according to the Company's statutory annual accounts (i.e., the amount of the assets as shown in the balance sheet, decreased with provisions and liabilities, all as prepared in accordance with Belgian accounting rules), decreased with the non-amortized costs of incorporation and expansion and the non-amortized costs for research and development, does not fall below the amount of the paid-up capital (or, if higher, the called capital), increased by the amount of non-distributable reserves. Finally, prior to distributing dividends, the Company must allocate at least 5% of the annual net profits (under the Company's non-consolidated statutory accounts prepared in accordance with Belgian accounting rules) to a legal reserve, until the reserve amounts to 10% of the Company's share capital.

In addition to the above test, the Company must also meet a liquidity test in order to be able to declare and/or distribute dividends.

During the extraordinary shareholders meeting of May 25, 2021, the shareholders, in accordance with Belgian Companies and Associations Code, approved the absorption of approximately €43.3 million of accounting losses into share premium. As a result, share premium had been reduced by a cumulative amount of €43.3 million in the 12 months period ended December 31, 2021 (€234.6 million of loss absorption has been approved and recorded from inception to December 31, 2022, as no such loss absorption occurred in 2022) against capital reduction reserve. This transaction has no impact on the total equity, comprehensive income (loss), assets (including cash) nor liabilities.

NOTE 16: SHARE-BASED PAYMENTS

The Group operates an equity-based compensation plan, whereby warrants are granted to directors, management and selected employees and non-employees. The warrants are accounted for as equity-settled share-based payment plans since the Group has no legal or constructive obligation to repurchase or settle the warrants in cash.

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Each warrant gives the beneficiaries the right to subscribe to one common share of the Group. The warrants are granted for free and have an exercise price equal to the lower of the average closing price of the Group's share over the 30 days prior to the offer, and the last closing price before the day of the offer, as determined by the Board of Directors of the Group.

Changes in the number of warrants outstanding and their related weighted average exercise prices are as follows:

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| | | | | |
|:---|:---|:---|:---|:---|
|  | 2022 | 2022 | 2022 | 2021 |
|  | Weighted average<br> exercise price (in €) | Number of warrants | Weighted average<br> exercise price (in €) | Number of warrants |
| Outstanding as of January 1, | 13.06 | 2 136 556 | 17.00 | 1 488 006 |
| Granted | 1.82 | 594 450 | 5.29 | 760 800 |
| Forfeited | 2.74 | (109 108) | 4.94 | (77 250) |
| Exercised |  |  |  |  |
| Expired | 15.80 | (282 252) | 10.23 | (35 000) |
| At December 31, | 8.36 | 2 339 646 | 13.06 | 2 136 556 |

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Warrants outstanding at the end of the year have the following expiry date and exercise price:

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| | | | | | |
|:---|:---|:---|:---|:---|:---|
| Warrant plan<br>issuance date | Vesting date | Expiry date | Number of warrants<br> outstanding as of<br> December 31, 2022 | Number of warrants<br> outstanding as of<br> December 31, 2021 | Exercise<br> price per<br> share |
| 06 May 2013 | 06 May 2016 | 06 May 2023 | 2 500 | 2 500 | 2.64 |
| 05 May 2014 | 05 May 2017 | 05 May 2024 | 35 698 | 35 698 | 38.25 |
| 05 November 2015 | 05 November 2018 | 05 November 2025 | 79 315 | 79 315 | 30.67 |
| 08 December 2016 | 08 December 2019 | 08 December 2021 | 7 500 | 7 500 | 32.04 |
| 29 June 2017 | 29 June 2020 | 31 July 2022 |  | 282 251 | 31.34 |
| 26 October 2018 | 26 October 2021 | 31 December 2023 | 365 817 | 365 817 | 18.26 |
| 25 October 2019 | 25 October 2022 | 31 December 2024 | 529 950 | 549 842 | 7.13 |
| 11 December 2020 | 10 December 2023 | 31 December 2027 | 498 883 | 532 133 | 6.24 |
| 11 October 2021 | 11 October 2024 | 31 December 2028 | 819 983 | 281 500 | 2.38 |
|  |  |  | 2 339 646 | 2 136 556 |  |

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The Group has a reserve of 568,500 authorized warrants for share based compensation plan as of December 31, 2022.

Warrants issued on May 6, 2013

At the Extraordinary Shareholders Meeting of May 6, 2013, a plan of 266,241 warrants was approved. Warrants were offered to Group's employees and management team. Out of the 266,241 warrants offered, 253,150 warrants were accepted by the beneficiaries and 2,500 warrants are outstanding as of December 31, 2022.

The 253,150 warrants were vested in equal tranches over a period of three years. The warrants become 100% vested after the third anniversary the issuance. The warrants that are vested can only be exercised at the end of the third calendar year following the issuance date, thus starting on January 1, 2017. The exercise price amounts to €2.64. Warrants not exercised within 10 years after issue become null and void.

Warrants issued on May 5, 2014

At the Extraordinary Shareholders Meeting of May 5, 2014, a plan of 100,000 warrants was approved. Warrants were offered to Group's employees, non-employees and directors in five different tranches. Out of the warrants offered, 94,400 warrants were accepted by the beneficiaries and 35,698 warrants are outstanding as of December 31, 2022.

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The 100,000 warrants were vested in equal tranches over a period of three years. The warrants become 100% vested after the third anniversary the issuance. The warrants that are vested can only be exercised at the end of the third calendar year following the issuance date, thus starting on January 1, 2018. The exercise price of the different tranches ranges from €33.49 to €45.05. Warrants not exercised within 10 years after issue become null and void.

Warrants issued on 5 November 2015

At the Extraordinary Shareholders Meeting of 5 November 2015, a plan of 466,000 warrants was approved. Warrants were offered to Group's employees, non-employees and directors in five different tranches. Out of the warrants offered, 353,550 warrants were accepted by the beneficiaries and 79,315 warrants are outstanding as of December 31, 2022.

These warrants vest in equal tranches over a period of three years. The warrants become 100% vested after the third anniversary of issuance. The warrants that are vested can only be exercised as from the end of the third calendar year following the issuance date, thus starting on January 1, 2019. The exercise price of the different tranches ranges from €15.90 to €34.65. Warrants not exercised within 10 years after issue become null and void.

Warrants issued on December 8, 2016

On December 8, 2016, the Board of Directors issued a new plan of 100,000 warrants. An equivalent number of warrants were cancelled from the remaining pool of warrants of the plan of November 5, 2015. Warrants were offered to Group's employees and non-employees in two different tranches. Out of the warrants offered, 45,000 warrants were accepted by the beneficiaries and 7,500 warrants are outstanding as of December 31, 2022.

These warrants will vest in equal tranches over a period of three years. The warrants become 100% vested after the third anniversary of issuance. The warrants that are vested can only be exercised as from the end of the third calendar year following the issuance date, thus starting on January 1, 2020. The exercise price of the different tranches ranges from €17.60 to €36.81. Warrants not exercised within 5 years after issue become null and void.

Warrants issued on June 29, 2017

At the Extraordinary Shareholders Meeting of June 29, 2017, a plan of 520,000 warrants was approved. Warrants were offered in different tranches to beneficiaries (employees, non-employees and directors). Out of the warrants offered, 334,400 warrants were accepted by the beneficiaries and no warrants are outstanding as of December 31, 2022, as they have expired in 2022.

These warrants will be vested in equal tranches over a period of three years. The warrants become 100% vested after the third anniversary of issuance. The warrants that are vested can only be exercised as from the end of the third calendar year following the issuance date, thus starting on January 1, 2021. The exercise price of the different tranches ranges from €31.34 to €48.89. Warrants not exercised within 5 years after issue become null and void.

Warrants issued on October 26, 2018

On October 26, 2018, the Board of Directors issued a new plan of 700,000 warrants. Warrants were offered in different tranches to beneficiaries (employees, non-employees and directors). Out of the warrants offered, 426,050 warrants were accepted by the beneficiaries and 365,817 warrants are outstanding as of December 31, 2022.

These warrants will vest in equal tranches over a period of three years. The warrants become 100% vested after the third anniversary of issuance. The warrants that are vested can only be exercised as from the end of the third calendar year following the issuance date, thus starting on January 1, 2022. The exercise price of the different tranches ranges from €9.36 to €22.04. Warrants not exercised within 5 years after issue become null and void after the 31st of December of the 5<sup>th</sup> year.

Warrants issued on October 25, 2019

On October 25, 2019, the Board of Directors issued a new plan of 939,500 warrants. Warrants were offered in different tranches to beneficiaries (employees, non-employees and directors). Out of the warrants offered, 602,025 warrants were accepted by the beneficiaries and 529,950 warrants are outstanding as of December 31, 2022. The increase in the number of warrants issued / granted in 2019 follows an update to our benchmark analysis which now incorporates development-stage, biotechnology peers from both Europe and the United States. In addition, the Group had a double allocation of warrants granted in 2019 (Q1:2019 and Q4:2019, respectively). Future double allocation of warrants may be considered. Finally, over the past two years, the Group recruited new EC members as well as new managers which are remunerated in warrants.

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These warrants will vest in equal tranches over a period of three years. The warrants become 100% vested after the third anniversary of issuance. The warrants that are vested can only be exercised as from the end of the third calendar year following the issuance date, thus starting on January 1, 2023. The exercise price of the different tranches ranges from €5.97 to €9.84. Warrants not exercised within 5 years after issue become null and void after the 31st of December of the 5<sup>th</sup> year.

Warrants issued on December 11, 2020

On December 11, 2020, the Board of Directors issued a new plan of 561,525 warrants. Warrants were offered in different tranches to beneficiaries (employees, non-employees and directors). Out of the warrants offered, 557,050 warrants were accepted by the beneficiaries and 498,883 warrants are outstanding as of December 31, 2022.

These warrants will vest in equal tranches over a period of three years. The warrants become 100% vested after the third anniversary of issuance. The warrants that are vested can only be exercised as from the end of the third calendar year following the issuance date, thus starting on January 1, 2024. The exercise price of the different tranches ranges from €3.72 to €6.81. Warrants not exercised within 7 years after issue become null and void after the 31st of December of the 7<sup>th</sup> year.

Warrants issued on October 11, 2021

On October 11, 2021, the Board of Directors issued a new plan of 777,050 warrants. Warrants were offered in different tranches to beneficiaries (employees, non-employees and directors). Out of the warrants offered, 874.200 warrants were accepted by the beneficiaries and 819,983 warrants are outstanding as of December 31, 2022. The difference between the number warrants offered on the 2021 plan and the number of newly issued warrants by the Board on October 11, 2021 is driven by the offer of additional warrants from the reserve of authorized warrants available from previous years plans.

These warrants will vest in equal tranches over a period of three years. The warrants become 100% vested after the third anniversary of issuance. The warrants that are vested can only be exercised as from the end of the third calendar year following the issuance date, thus starting on January 1, 2025. The exercise price of the different tranches ranges from €1.64 to €3.75. Warrants not exercised within 7 years after issue become null and void after the 31st of December of the 7<sup>th</sup> year.

Warrants issued on October 5, 2022

On October 5, 2022, the Board of Directors issued a new plan of 323,700 warrants. Warrants were offered in different tranches to beneficiaries (employees, non-employees and directors). Out of the warrants offered, no warrants were accepted by the beneficiaries and no warrants are outstanding as of December 31, 2022.

As a result, as of December 31, 2022, there are 2,339,646 warrants outstanding which represent respectively 9.38% of the total number of all its issued and outstanding shares and 8.57% of the total voting financial instruments.

The fair value of the warrants has been determined at grant date based on the Black-Scholes formula. The variables, used in this model, are:

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| | | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
|  | Warrants issued on | Warrants issued on | Warrants issued on | Warrants issued on | Warrants issued on | Warrants issued on | Warrants issued on | Warrants issued on | Warrants issued on | Warrants issued on |
|  | 06 May<br> 2013 | 05 May<br> 2014 | 05 Nov.<br> 2015 | 08 Dec.<br> 2016 | 29 Jun.<br> 2017 | 26 Oct.<br> 2018 | 25 Oct.<br> 2019 | 10 Dec.<br> 2020 | 11 Oct.<br> 2021 | Total |
| Number of warrants issued | 266 241 | 100 000 | 466 000 | 100 000 | 520 000 | 700 000 | 939 500 | 561 525 | 777 050 | 4 430 316 |
| Number of warrants accepted | 253 150 | 94 400 | 353 550 | 45 000 | 334 400 | 426 050 | 602 025 | 557 050 | 874 200 | 3 539 825 |
| Number of warrants not fully <br>vested as of December 31, <br>2022 |  |  |  |  |  |  | 289 834 | 498 883 | 819 983 | 1 608 700 |
| Average exercise price (in €) | 2.64 | 38.25 | 30.67 | 32.04 | 31.34 | 18.26 | 7.13 | 6.24 | 2.38 |  |
| Expected share value <br>volatility | 39.55% | 67.73% | 60.53% | 61.03% | 60.61% | 58.82% | 59.14% | 58.84% | 56.86% |  |
| Risk-free interest rate | 2.06% | 1.09% | 0.26% | -0.40% | -0.23% | -0.06% | -0.38% | -0.66% | -0.30% |  |
| Average fair value (in €) | 12.44 | 25.19 | 20.04 | 16.18 | 15.58 | 8.90 | 3.99 | 3.45 | 1.36 |  |
| Weighted average remaining <br>contractual life | 0.34 | 1.34 | 2.84 | (1.07) | (0.51) | 0.82 | 1.81 | 4.94 | 5.78 |  |

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The total expense recognized in the income statement for the outstanding warrants totals €1.6 million for the year 2022 (€2.2 million of expense for the prior year 2021).

NOTE 17: POST-EMPLOYMENT BENEFITS

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| | | |
|:---|:---|:---|
| (€'000) | As at December 31, | As at December 31, |
|  | 2022 | 2021 |
| Pension obligations | 13 | 53 |
| Total | 13 | 53 |

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The Group operates a pension plan which requires contributions to be made by the Group to an insurance company. The pension plan is a defined contribution plan. However, because of the Belgian legislation applicable to 2nd pillar pension plans (so-called "Law Vandenbroucke"), the Group's defined contribution plan is accounted under IAS 19 .

At the end of each year, the Group is measuring and accounting for the potential impact of defined benefit accounting for these pension plans with a minimum fixed guaranteed return.

The contributions to the plan are determined as a percentage of the yearly salary. There are no employee contributions. The benefit also includes a death in service benefit.

The amounts recognized in the statement of financial position are determined as follows:

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| | | |
|:---|:---|:---|
| (€'000) | As at December 31, | As at December 31, |
|  | 2022 | 2021 |
| Present value of funded obligations | 2 568 | 2 408 |
| Fair value of plan assets | (2 555) | (2 355) |
| Deficit of funded plans | 13 | 53 |
| Total deficit of defined benefit pension plans | 13 | 53 |
| Liability in the statement of financial position | 13 | 53 |

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The change in the defined benefit liability over the year is as follows:

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| | | | |
|:---|:---|:---|:---|
| (€'000) | Present value<br> of obligation | Fair value of<br> plan assets | Total |
| At January 1, 2021 | 2 747 | 2 133 | 614 |
| Current service cost | 206 |  | 206 |
| Interest expense/(income) | 18 | 49 | (31) |
|  | 2 971 | 2 182 | 789 |
| Remeasurements |  |  |  |
| - Actuarial (Gain)/loss due to change in actuarial assumptions | (17) |  | (17) |
| - Actuarial (Gain)/loss due to change in demographic assumptions | 36 |  | 36 |
| - Actuarial (Gain)/Loss due to experience | (537) |  | (537) |
|  | (518) |  | (518) |
| Employer contributions: |  | 218 | (218) |
| Benefits Paid | (45) | (45) |  |
| At December 31, 2021 | 2 408 | 2 355 | 53 |

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| | | | |
|:---|:---|:---|:---|
| At January 1, 2022 | 2 408 | 2 355 | 53 |
| Current service cost | 169 |  | 169 |
| Interest expense/(income) | 26 | 23 | 3 |
|  | 2 603 | 2 378 | 225 |
| Remeasurements |  |  |  |
| - Actuarial (Gain)/loss due to change in actuarial assumptions | (13) |  | (13) |
| - Actuarial (Gain)/Loss due to experience | 26 |  | 26 |
| - Curtailment in year | (3) |  | (3) |
|  | 10 |  | 10 |
| Employer contributions: |  | 222 | (222) |
| Benefits Paid | (45) | (45) |  |
| At December 31, 2022 | 2 568 | 2 555 | 13 |

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The plan assets are 100% invested in an insurance product.

The income statement charge included in operating profit for post-employment benefits amount to:

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| | | | |
|:---|:---|:---|:---|
| (€'000) | 2022 | 2021 | 2020 |
| Current service cost | 169 | 206 | 233 |
| Interest expense on DBO | 26 | 18 | 30 |
| Expected return on plan assets | (24) | (13) | (24) |
| Amount recognized on curtailment/settlement | (3) |  |  |
| Net periodic pension cost | 168 | 211 | 239 |

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The re-measurements included in other comprehensive loss amount to:

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| | | | |
|:---|:---|:---|:---|
| (€'000) | 2022 | 2021 | 2020 |
| Effect of changes in actuarial assumptions | (13) | (17) | 187 |
| Effect of experience adjustments | 26 | (537) | 24 |
| Effect of changes in demographic assumptions |  | 36 |  |
| (Gain)/Loss on assets for the year | 2 | (36) | (14) |
| Remeasurement of post-employment benefit obligations | 15 | (554) | 197 |

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Plan assets relate all to qualifying insurance policies. The significant actuarial assumptions as per December 31, 2022 were as follows:

Demographic assumptions (for both current and comparative years presented in these year-end financial statements):

• Mortality tables: mortality rates-5 year for the men and 5 year for the women

• Withdrawal rate: 13.5% for age <55, 0.0% for age ≥55 (no change compared to comparative period)

• Retirement age: 65 years

Economic assumptions:

• Yearly inflation rate: 2.2% (vs 2.0% compared to comparative period)

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• Yearly salary raise: 1.5% (above inflation), no change compared to comparative period

• Yearly discount rate: 3.8% (vs 1.0% last year). The discount rate reflects the yield on high quality (AA) long-term corporate bonds (within the EURO zone) having the same duration as the duration of the pension liabilities at the valuation date.

If the discount rate would decrease by 0.5% then, the defined benefit obligation would increase by 0.00%. If the discount rate would increase by 0.5% then the defined benefit obligation would decrease by 0.00%.

The above sensitivity analysis is based on a change in an assumption while holding all other assumptions constant. In practice, this is unlikely to occur, and changes in some of the assumptions may be correlated. When calculating the sensitivity of the defined benefit obligation to significant actuarial assumptions the same method (present value of the defined benefit obligation calculated with the projected unit credit method at the end of the reporting period) has been applied as when calculating the pension liability recognized within the statement of financial position.

Through its defined benefit pension plan, the Group is exposed to several risks, the most significant of which are detailed below:

• Changes in discount rate: a decrease in discount rate will increase plan liabilities;

• Inflation risk: the pension obligations are linked to inflation, and higher inflation will lead to higher liabilities. The majority of the plan's assets are either unaffected by or loosely correlated with inflation, meaning that an increase in inflation will also increase the deficit.

The investment positions are managed by the insurance company within an asset-liability matching framework that has been developed to achieve long-term investments that are in line with the obligations under the pension schemes.

Expected contributions to pension plans for next financial year amount to €0.2 million.

NOTE 18: OTHER RESERVES

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| | | | | |
|:---|:---|:---|:---|:---|
| (€'000) | Share based<br> payment reserve | Other equity<br> reserve from<br> conversion of<br> convertible<br> loan in 2013 | Currency<br> Translation<br> Difference | Total |
| Balance as at January 1, 2021 | 15 803 | 16 631 | (1 476) | 30 958 |
| Vested share-based payments | 2 172 |  |  | 2 172 |
| Currency Translation differences subsidiaries |  |  | 42 | 42 |
| Balance as at December 31, 2021 | 17 975 | 16 631 | (1 434) | 33 172 |
| Vested share-based payments | 1 624 |  |  | 1 624 |
| Currency Translation differences subsidiaries |  |  | 4 | 4 |
| Balance as at December 31, 2022 | 19 599 | 16 631 | (1 430) | 34 800 |

---

The amount of €16.6 million has been accounted for as other reserves following the conversion of the loans E, F, G and H on May 31, 2013, as a legacy IFRS adjustment on fully settled contribution-in-kind convertible loans.

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NOTE 19: RECOVERABLE CASH ADVANCES

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| | | |
|:---|:---|:---|
| (€'000) | As at December 31, | As at December 31, |
|  | 2022 | 2021 |
| Non-Current portion as at January 1, | 5 851 | 4 220 |
| Non-Current portion as at December 31, | 4 584 | 5 851 |
| Current portion as at January 1, | 362 | 371 |
| Current portion as at December 31, | 437 | 362 |
| Total Recoverable Cash Advances as at January 1, | 6 213 | 4 590 |
| Total Recoverable Cash Advances as at December 31, | 5 021 | 6 213 |

---

The Group receives government support in the form of recoverable cash advances from the Walloon Region in order to compensate the research and development costs incurred by the Group. Refer to notes 3 and 24.

At December 31, 2022, the Group has been granted recoverable cash advances amounting to €25.8 million related active contracts. Out of this amount: i) €21.8 million have been received to date; ii) €2.5 million should be received in 2023 or later depending on the progress of the different programs partially funded by the Region; iii) €1.5 million have been decommitted due to the end of the expenses submission period linked to the R&D period. In addition, the Group has received recoverable cash advances amounting to €15.3 million related to contracts for which the exploitation has been abandoned (mainly related to the C-Cure program).

For further details, reference is made to the table below which shows, for active contracts (i) the year for which amounts under those agreements have been received and initially recognized on the statement of financial position for the financial liability and deferred grant income components and (ii) a description of the specific characteristics of those recoverable cash advances including repayment schedule and information on other outstanding advances. Underlying R&D is ongoing. In 2023 and beyond, the Group will have to make exploitation decisions on the remaining RCAs (agreements numbered 8212, 8436 and 8516).

---

| | | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| (in €'000) | (in €'000) | (in €'000) | Amounts received for the years<br> ended December 31, | Amounts received for the years<br> ended December 31, | Amounts received for the years<br> ended December 31, | Amounts to be received | Amounts to be received | Amounts to be received | Amounts to be received | As at<br> December 31,<br> 2022 |
| Id | Project | Contractual<br> amount | Prior<br> years | 2021 | 2022 | Cumulated<br> cashed in | 2023 and<br> beyond | Amounts<br> decommitted | Status | Amount<br> reimbursed<br> (cumulative) |
| 5915 | C-Cathez | 910 | 910 |  |  | 910 |  |  | Exploitation | 740 |
| 6633 | C-Cathez | 1 020 | 1 020 |  |  | 1 020 |  |  | Exploitation | 306 |
| 7027 | C-Cathez | 2 500 | 2 500 |  |  | 2 500 |  |  | Exploitation | 675 |
| 7502 | CAR-T Cell | 2 000 | 2 000 |  |  | 2 000 |  |  | Exploitation | 100 |
| 7685 | THINK | 3 496 | 3 496 |  |  | 3 496 |  |  | Exploitation | 105 |
| 8087 | CYAD01 - Deplethink | 2 492 | 2 070 |  |  | 2 070 |  | 421 | Exploitation |  |
| 8088 | CYAD02 - Cycle1 | 3 538 | 1 500 | 746 | 222 | 2 468 |  | 1 071 | Exploitation |  |
| 1910028 | CwalityCAR | 2 102 | 749 | 199 | 1 113 | 2 061 |  | 41 | Exploitation |  |
| 8212 | CYAD-101 | 3 300 | 825 | 1 370 | 775 | 2 970 | 330 |  | Research |  |
| 8436 | Immunicy | 3 394 | 1 697 |  | 348 | 2 045 | 1 349 |  | Research |  |
| 8516 | New engagers | 1 095 |  | 274 |  | 274 | 821 |  | Research |  |
| Total |  | 25 847 | 16 767 | 2 589 | 2 458 | 21 814 | 2 500 | 1 533 |  | 1 926 |

---

Regarding active contracts (in exploitation and research status):

The contract 5915 has the following specific characteristics:

• funding by the Region covers 70% of the budgeted project costs;

• certain activities have to be performed within the Region;

• in case of an outlicensing agreement or a sale to a third party, the Group will have to pay 10% of the price received (excl. of VAT) to the Region;

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• sales-independent reimbursements, sales-dependent reimbursements, and amounts due in case of an outlicensing agreement or a sale to a third party, are, in the aggregate, capped at 100% of the principal amount paid out by the Region;

• sales-dependent reimbursements payable in any given year can be set-off against sales-independent reimbursements already paid out during that year;

• the amount of sales-independent reimbursement and sales-dependent reimbursement may possibly be adapted in case of an outlicensing agreement, a sale to a third party or industrial use of a prototype or pilot installation, when obtaining the consent of the Walloon Region to proceed thereto.

The RCA liability associated to the contract 5915 amounted to €0.2 million.

The other contracts have the following specific characteristics:

• funding by the Region covers from 45% to 70% of the budgeted project costs;

• certain activities have to be performed within the EU;

• sales-independent reimbursements represent in the aggregate 30% of the principal amount;

• sales-independent reimbursements and sales-dependent reimbursements are, in the aggregate (including the accrued interests), capped at 200% of the principal amount paid out by the Region;

• interests (at Euribor 1 year (as applicable on the first day of the month in which the decision to grant the relevant RCA was made + 100 basis points) accrue as of the 1st day of the exploitation phase;

• the amount of sales-independent reimbursement and sales-dependent reimbursement may possibly be adapted in case of an outlicensing agreement, a sale to a third party or industrial use of a prototype or pilot installation, when obtaining the consent of the Region to proceed thereto.

• in case of bankruptcy, the research results obtained by the Group under those contracts are expressed to be assumed by the Region by operation of law.

The RCA liability associated to the other contracts amounted to €4.8 million, which mainly incorporate the sales-independent reimbursements for €4.8 million and the sales-dependent reimbursements for €0.0 million.

The table below summarizes, in addition to the specific characteristics described above, certain terms and conditions for the recoverable cash advances:

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| Contract number | Research phase | Percentage<br> of total<br> project<br> costs | Turnover-<br> dependent<br> reimbursement | Turnover-independent reimbursement | Interest<br> rate<br> accrual | Amounts<br> due in case<br> of licensing<br> (per year)<br> resp. Sale |
| (€'000) |  |  |  |  |  |  |
| 5915 | 01/08/08-30/04/11 | 70% | 5.00% | €40k in 2012 and €70k each year after | N/A | 10% with a minimum of 100/Y |
| 6633 | 01/05/11-30/11/12 | 60% | 0.27% | From €10k to €51k starting in 2013 until 30% of advance is reached | Starting 01/06/13 | N/A |
| 7027 | 01/11/12-31/10/14 | 50% | 0.33% | From €25k to €125k starting in 2015 until 30% of advance is reached | Starting 01/01/15 | N/A |
| 7502 | 01/12/15-30/11/18 | 45% | 0.19% | From €20k to €50k starting in 2019 until 30% is reached. | Starting 01/12/19 | N/A |
| 7685 | 01/01/17-31/12/19 | 45% | 0.33% | From €35k to €70k starting in 2019 until 30% is reached. | Starting 01/01/21 | N/A |
| 8087 | 01/05/19- 30/06/21 | 45% | 0.22% | From €20k to €61k starting in 2022 until 30% is reached | Starting 01/07/22 | N/A |
| 8088 | 01/05/19- 31/12/21 | 45% | 0.21% | From €25k to €74k starting in 2022 until 30% is reached | Starting 01/01/22 | N/A |
| 1910028 | 06/06/19- 05/06/22 | 45% | 0.01% | From €21k to €41k starting in 2022 until 30% is reached | Starting 06/06/22 | N/A |
| 8212 | 01/01/20- 30/06/23 | 45% | 0.46% | From €33k to €99k starting in 2024 until 30% is reached | Starting 01/07/23 | N/A |
| 8436 | 01/11/20- 31/12/23 | 45% | 0.32% | From €34k to €102k starting in 2024 until 30% is reached | Starting 01/01/24 | N/A |
| 8516 | 01/04/21-31/03/23 | 45% | 0.10% | From €11k to 33k starting in 2024 until 30% is reached | Starting 01/04/23 | N/A |

---

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NOTE 20: DUE DATES OF THE FINANCIAL LIABILITIES

The table below analyses the Group's non-derivative financial liabilities into relevant maturity groupings based on the remaining period at the statement of financial position date to the contractual maturity date. The amounts disclosed in the table are the contractual undiscounted cash flows, except for advances repayable which are presented at amortized cost. Contingent consideration liability has not been disclosed in the table below, because as of statement of financial position date, it does not meet the definition of a contractual obligation. Commitments relating to contingent consideration are detailed in the note 34.

Financial liabilities reported as at December 31, 2022:

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| | | | | | |
|:---|:---|:---|:---|:---|:---|
| (€'000) | Total | Less than one<br> year | One to three<br> years | Three to five<br> years | More than five<br> years |
| As at December 31, 2022 |  |  |  |  |  |
| Lease liabilities (undiscounted) | 259 | 141 | 118 |  |  |
| Pension obligations | 13 |  |  |  | 13 |
| Advances repayable (current and non-current) | 5 021 | 437 | 640 | 637 | 3 307 |
| Total financial liabilities | 5 293 | 578 | 758 | 637 | 3 320 |

---

Financial liabilities reported as at December 31, 2021:

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| (€'000) | Total | Less than one<br> year | One to three<br> years | Three to five<br> years | More than five<br> years |
| As at December 31, 2021 |  |  |  |  |  |
| Lease liabilities (undiscounted) | 2 965 | 1 057 | 1 431 | 477 |  |
| Pension obligations | 53 |  |  |  | 53 |
| Advances repayable (current and non-current) | 6 213 | 362 | 616 | 740 | 4 495 |
| Total financial liabilities | 9 231 | 1 419 | 2 047 | 1 217 | 4 548 |

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NOTE 21: OTHER NON-CURRENT LIABILITIES

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| | | |
|:---|:---|:---|
| (€'000) | As at December 31, | As at December 31, |
|  | 2022 | 2021 |
| Onerous contracts - non-current liabilities | 124 |  |
| Other non-current liabilities | 134 | 164 |
| Total Other non-current liabilities | 258 | 164 |

---

As of December 31, 2022, the Group recorded a provision for onerous contracts for a total amount of €2.2 million in order to cover the contractual obligations, mainly on clinical activities follow-up and studies closing costs, after the Group's decision in the fourth quarter of 2022, to discontinue the development of its remaining clinical programs CYAD-02, CYAD-101 and CYAD-211. The non-current portion of this provision as of December 31, 2022 amounts to €0.1 million. The current portion of the provision is €2.1 million as of December 31, 2022 (see note 22).

As of December 31, 2021, the Group recorded a non-current liability of €0.2 million regarding a non-refundable, non-creditable sublicense fee to be paid on an annual basis to Dartmouth in connection with the December 2021 amendment agreement (see note 34). As of December 31, 2022, the non-current liability is €0.1 million.

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NOTE 22: TRADE PAYABLES AND OTHER CURRENT LIABILITIES

---

| | | |
|:---|:---|:---|
| (€'000) | As at December 31, | As at December 31, |
|  | 2022 | 2021 |
| Total Trade payables | 4 752 | 6 611 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Social security | 94 | 332 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Payroll accruals | 1 294 | 1 798 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Onerous contracts - current liabilities | 2 113 | 388 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Other current grant liabilities | 889 | 1 096 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Other current liabilities | 710 | 2 338 |
| Total Other current liabilities | 5 100 | 5 952 |
| Total Trade payables and other current liabilities | 9 852 | 12 563 |

---

Trade payables

Trade payables are non-interest-bearing liabilities and are normally settled on 90-day terms. Their decrease is mainly attributable to the timing of the expenses and the related payments combined with a decrease of activities after the sale of CTMU activities and the strategic shift from an organization focused on clinical development to one prioritizing R&D discovery and the monetization of its IP portfolio through partnerships, collaborations and license agreements through the second semester of the year. The Group recognized estimated accruals for invoices to receive based on estimated amounts of rendered services or delivered goods during the year 2022 but not yet invoiced as per December 31, 2022 for an amount of approximately €2.8 million.

Other current liabilities

As of December 31, 2022, the decrease on social security and payroll accruals of €0.7 million compared to December 31, 2021 is mainly related to the headcount reduction in 2022.

As of December 31, 2021, the provision for onerous contracts was related to the Group's decision to discontinue the development of CYAD-01. As of December 31, 2022, the Group recorded a provision for onerous contracts, refer to note 5.17.

The other current liabilities attached to RCA's and other grants are mainly explained by the excess of cash proceeds compared to the eligible expenses. The decrease compared to year-end 2021 is mainly related to the convention 8436 due to eligible expenses subsidized by the convention recognized in 2022.

Other current liabilities decreased by €1.6 million, which is mainly explained by repayment of R&D tax credit to the federal government in the amount of €1.9 million related to the years 2013, 2014 and 2015, offset by an increase of deferred revenue by €0.2 million as part of contract with customer to sell C-Cathez medical devices.

No discounting was performed to the extent that the amounts do not present payments terms longer than one year at the end of each financial year presented.

NOTE 23: FINANCIAL INSTRUMENTS

Financial instruments not reported at fair value on statement of financial position

The carrying and fair values of financial instruments that are not reported at fair value in the consolidated financial statements were as follows for the current and comparative periods:

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---

| | | |
|:---|:---|:---|
| (€'000) | As at December 31, 2022 | As at December 31, 2022 |
|  | Financial assets at<br> amortized cost | Fair value |
| Financial Assets ('Amortized cost' category) within: |  |  |
| Non-current Trade receivables |  |  |
| Other non-current assets | 264 | 264 |
| Trade receivables and other current assets | 1 118 | 1 118 |
| Short-term investments |  |  |
| Cash and cash equivalents | 12 445 | 12 445 |
| Total | 13 827 | 13 827 |

---

For the above-mentioned financial assets, the carrying amount as per December 31, 2022, is a reasonable approximation of their fair value.

---

| | | |
|:---|:---|:---|
| (€'000) | As at December 31, 2022 | As at December 31, 2022 |
|  | Financial liabilities at<br> amortized cost | Fair value |
| Financial Liabilities ('Financial liabilities at amortized cost' category) within: | Financial Liabilities ('Financial liabilities at amortized cost' category) within: |  |
| Lease liabilities | 255 | 255 |
| RCAs liability | 5 021 | 5 021 |
| Trade payables | 4 752 | 4 752 |
| Total | 10 028 | 10 028 |

---

For the above-mentioned financial liabilities, the carrying amount as per December 31, 2022, is a reasonable approximation of their fair value.

---

| | | |
|:---|:---|:---|
| (€'000) | As at December 31, 2021 | As at December 31, 2021 |
|  | Financial assets at<br> amortized cost | Fair value |
| Financial Assets ('Amortized cost' category) within: |  |  |
| Non-current Trade receivables | 2 209 | 2 209 |
| Other non-current assets | 262 | 262 |
| Trade receivables and other current assets | 668 | 668 |
| Short-term investments |  |  |
| Cash and cash equivalents | 30 018 | 30 018 |
| Total | 33 157 | 33 157 |

---

For the above-mentioned financial assets, the carrying amount as per December 31, 2021, is a reasonable approximation of their fair value.

---

| | | |
|:---|:---|:---|
| (€'000) | As at December 31, 2021 | As at December 31, 2021 |
|  | Financial liabilities at<br> amortized cost | Fair value |
| Financial Liabilities ('Financial liabilities at amortized cost' category) within: | Financial Liabilities ('Financial liabilities at amortized cost' category) within: |  |
| Finance lease liabilities | 2 632 | 2 632 |
| RCAs liability | 6 213 | 6 213 |
| Trade payables and other current liabilities | 6 611 | 6 611 |
| Total | 15 456 | 15 456 |

---

For the above-mentioned financial liabilities, the carrying amount as per December 31, 2021, is a reasonable approximation of their fair value.

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Financial instruments reported at fair value on statement of financial position

Contingent consideration and other financial liabilities are reported at fair value in the statement of financial position using Level 3 fair value measurements for which the Group developed unobservable inputs.

---

| | | | | |
|:---|:---|:---|:---|:---|
| (€'000) | As at December 31, 2022 | As at December 31, 2022 | As at December 31, 2022 | As at December 31, 2022 |
|  | Level I | Level II | Level III | Total |
| Liabilities |  |  |  |  |
| Contingent consideration and other financial liabilities |  |  |  |  |
| Total Liabilities |  |  |  |  |

---

---

| | | | | |
|:---|:---|:---|:---|:---|
| (€'000) | As at December 31, 2021 | As at December 31, 2021 | As at December 31, 2021 | As at December 31, 2021 |
|  | Level I | Level II | Level III | Total |
| Liabilities |  |  |  |  |
| Contingent consideration and other financial liabilities |  |  | 14 679 | 14 679 |
| Total Liabilities |  |  | 14 679 | 14 679 |

---

After initial recognition, contingent consideration liabilities are re-measured at fair value with changes in fair value recognized in profit or loss in accordance with IFRS 3.

The change in the balance is detailed as follows:

---

| | | |
|:---|:---|:---|
| (€'000) | For the year ended | For the year ended |
|  | 2022 | 2021 |
| Opening balance Contingent consideration at January 1, | 14 679 | 15 526 |
| Milestone payment |  |  |
| Fair value adjustment | (14 679) | (847) |
| Closing balance Contingent consideration at December 31, |  | 14 679 |

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The contingent consideration and other financial liabilities refer to the acquisition of the Group's immuno-oncology platform and corresponds to the fair value of the potential future payments due to Celdara Medical, LLC and Dartmouth College (as disclosed within note 34).

The valuation is prepared by the Finance Team on a quarterly basis and reviewed by the Management. The Management's key assumptions about projected cash flows when determining fair value less costs to sell are the same key assumptions than for impairment testing purposes (see note 7). There has not been any change in valuation technique in 2022 compared to 2021, at the exception of the change on key assumptions about projected cash flows as described below.

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As documented in the notes 1 and 7, Management had to conclude on the full reversal of the contingent consideration and other financial liabilities associated the potential future payments due to Celdara Medical, LLC and Dartmouth College associated to the Group's immuno-oncology platform at December 31, 2022. This accounting conclusion, which reflects a picture of the situation at December 31, 2022, doesn't affect the Management's commitment to continue the exploitation of these IPs in its new strategy Celyad 2.0.

As soon as a future event (such as a firm sublicense or collaboration contract) will increase the probability of the projected future cash outflow due to Celdara Medical, LLC and Dartmouth College, indicating that the probability is more than remote, the Group will reassess the contingent consideration and other financial liabilities proportionally to the revised fair value of such consideration.

For comparative purpose, as of December 31, 2021, the liability evolution reflects the development of the Group's product candidates using CAR T technology and their progress towards market approval in both autologous and allogeneic programs, as well as the update of its underlying business plans and revenue forecast.

As of December 31, 2021, Management's key assumptions (assumptions to which the unit's or group of units', recoverable amount is most sensitive) about projected cash flows when determining fair value less costs to sell are the same key assumptions was utilized for impairment testing purposes (see note 7):

• Discount rate (WACC)

The Management had determined that the Weighted Average Cost of Capital (WACC) was the most appropriate rate to use as it represents the risk associated with both equity and the debt. Contingent consideration is a liability and thus the discount rate should represent debt features, but the "contingent" nature of the liability has similar features as equity, e.g., return is not guaranteed and thus equity risk should be considered as well. Management estimated the discount rate (WACC) as of December 31, 2021 to be 13.4% based on following components: the US Government Treasury bill 20-Y, the Group's Beta, the equity Market Risk Premium and the small firm/illiquidity premium. The decrease of the WACC was mainly driven by a decrease of the Beta of the Group which is associated with the volatility of the Group's equity influenced by its ongoing clinical programs and overall competitive landscape within the immuno-oncology field. Management corroborates its estimation with industry standards for biotechnology companies, the WACC used by Equity Research companies following the Group and transactions that had been sourced by the Group over the past 24 months.

• Projected Revenue

Management had estimated the projected revenue (using cash flow projections ending in 2040) based on the following components: total market and market share, time-to-market, treatment price and terminal value. Management based its estimation of projected revenue and related components with the Group's business plan, industry data for biotechnology companies, evolution of similar R&D programs, comparable prices, expected patent expiration period. The weight of this assumption was partially alleviated by the probability of success (PoS) presented hereunder.

• Probabilities of Success (PoS)

Management had estimated the PoS based on Clinical Development Success Rates observed by independent business intelligence consulting companies for hematological and solid tumor diseases. Probability of the Group's product candidates reaching the market used were updated based on most recent Clinical Development Success Rates observed by independent business intelligence consulting companies for hematological and solid tumor diseases and incorporate data for clinical development success rates from 2011 – 2020, which the Group believed was a more accurate reflection of clinical development success rates across stage of development and in aggregate, as follows:

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| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| PoS | Phase<br> I | Phase I to Phase<br> II | Phase II to Phase<br> III | Phase III to<br> BLA | BLA to<br> Approval | Cumulative PoS |
| CYAD-02 | 100% | 50% | 28% | 60% | 90% | 7.5% |
| CYAD-101 | 100% | 49% | 23% | 43% | 93% | 4.6% |

---

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As of December 31, 2021, the change in fair value of the liability was mainly due to:

• The update of the assumptions associated with the timing of the potential commercialization of the Group's allogenic CYAD-101 CAR T program for mCRC which has been delayed by one year;

• The update of the assumptions associated with the timing, development and the potential commercialization of the Group's autologous CYAD-02 CAR T program for r/r AML/MDS to reflect the future development of the program through potential partnership, which has been delayed by one year;

• The update in WACC used for fair value measurement purposes at December 31, 2021;

• The revaluation of the U.S. dollar against the Euro; and

• The updated assumptions on Probability of Success (PoS) associated with the Group's CAR T programs.

NOTE 24: CHANGES IN LIABILITIES ARISING FROM FINANCIAL ACTIVITIES

The change in bank loans balances is detailed as follows:

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| | | |
|:---|:---|:---|
| BANK LOANS FINANCIAL LIABILITY ROLL FORWARD |  |  |
| (€'000) | For the year ended | For the year ended |
|  | 2022 | 2021 |
| Opening balance at January 1, |  | 37 |
| Payments |  | (37) |
| Closing balance at December 31, |  |  |

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The change in lease liability balances is detailed as follows:

---

| | | |
|:---|:---|:---|
| LEASES FINANCIAL LIABILITY ROLL FORWARD |  |  |
| (€'000) | For the year ended | For the year ended |
|  | 2022 | 2021 |
| Opening balance at January 1, | 2 632 | 3 602 |
| New leases | 170 | 129 |
| Payments | (896) | (1 099) |
| Remeasurement | (1 651) |  |
| Closing balance at December 31, | 255 | 2 632 |

---

New leases 2022 are mainly related to indexation on lease regarding properties. The remeasurement of the lease liabilities is mainly driven by the early termination of the leases on properties during the fourth quarter of 2022.

The change in recoverable cash advance liability balances is detailed as follows:

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| | | |
|:---|:---|:---|
| RECOVERABLE CASH ADVANCE LIABILITY ROLL FORWARD | RECOVERABLE CASH ADVANCE LIABILITY ROLL FORWARD |  |
| (€'000) | For the year ended | For the year ended |
|  | 2022 | 2021 |
| Opening balance at January 1, | 6 213 | 4 590 |
| Repayments | (230) | (280) |
| Proceeds - Liability component | 485 | 1 575 |
| Remeasurement | (1 447) | 328 |
| Closing balance at December 31, | 5 021 | 6 213 |

---

The RCAs are initially recognized as a financial liability at fair value, calculated based on present value of future repayment of grants (using initial effective discount rates ranging between 0% and 7% for the fixed part and between 13% to 25% for the variable part, depending on RCAs listed in note 19), determined as per IFRS 9. The benefit (RCA grant component) consisting in the difference between the cash received (RCA proceeds) and the financial liability's fair value (RCA liability component) is treated as a government grant in accordance with IAS 20.

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The RCAs liability component (RCA financial liability) is subsequently measured at amortized cost using the cumulative catch-up approach under which the carrying amount of the liability is adjusted to the present value of the future estimated cash flows (future estimated cash flow are measured by the management using same key assumptions than for the impairment testing in note 7). The resulting adjustment is recognized within profit or loss (see note 3).

The change in the recoverable cash advances liability at the statement of financial position date mainly reflects both the new grants received in current year as well as the remeasurement of the liability at amortized cost, based on the Group's updated business plan and related cash flow projections (see note 28). The year-end balance also captures the repayments of contractual turnover independent lump sums to the Walloon Region (mainly relating to C-Cathez agreements).

As documented in the notes 1 and 7, Management had to conclude that the possibility of any cash flow, associated with CAR T-cell and NKG2D-based therapies are remote and thus the fair value of the sales dependent liability is estimated to be zero, resulting remeasurement gain of €1.4 million.

NOTE 25: REVENUES

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| | | | |
|:---|:---|:---|:---|
| (€'000) | For the year ended December 31, | For the year ended December 31, | For the year ended December 31, |
|  | 2022 | 2021 | 2020 |
| Out-licensing revenue |  |  |  |
| Other revenue |  |  | 5 |
| Total |  |  | 5 |

---

The Group's license and collaboration agreements have generated no revenue for the year ended December 31, 2022 similar to the year ended December 31, 2021. The Group did not enter into any new license agreements for the 12-month period ended December 31, 2022.

The Group does not expect to generate material revenue unless and until the Group concludes partnerships with outside parties around the licensing of the patents around allogeneic CAR T-cell therapies and NKG2D-based therapies.

NOTE 26: OPERATING EXPENSES

The operating expenses are made of the next three components:

• Research & development expenses

• General and administrative expenses

• Non-recurring operating income and expenses

Research and development expenses

The following table is a summary of manufacturing expenses, clinical, quality and regulatory expenses and other research and development expenses, which are aggregated and presented as research and development expenses in the Group's consolidated financial statements.

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---

| | | | |
|:---|:---|:---|:---|
| (€'000) | For the year ended December 31, | For the year ended December 31, | For the year ended December 31, |
|  | 2022 | 2021 | 2020 |
| Employee expenses | 9 062 | 9 475 | 8 564 |
| Clinical study costs | 4 280 | 4 000 | 5 555 |
| Preclinical study costs | 1 233 | 2 473 | 1 976 |
| Depreciation | 1 231 | 1 276 | 1 511 |
| IP filing and maintenance fees | 831 | 353 | 230 |
| Rent and utilities | 610 | 670 | 800 |
| Share-based payments | 425 | 644 | 927 |
| Process development and scale-up | 396 | 770 | 1 056 |
| Consulting fees | 320 | 568 | 372 |
| Travel & Living | 126 | 85 | 116 |
| Delivery systems |  |  | 47 |
| Others | 415 | 459 | 369 |
| Total R&D expenses | 18 928 | 20 773 | 21 522 |

---

The changes in the R&D expenses are mainly driven by:

• The decrease of employee expenses mainly related to headcount reduction through the year ended December 31, 2022 to support the Group's reorganization around preclinical and clinical programs;

• The increase on clinical study costs mainly due to the new provision for onerous contracts for a total amount of €2.2 million in order to cover the contractual obligations after the Group's decision to discontinue the development of its remaining clinical programs CYAD-02, CYAD-101 and CYAD-211 taken in December 2022. The provision recorded to cover for contractual obligations through 2023 reaches an amount of €2.1 million (see note 22);

• The decrease of preclinical activities after the Group's decision to adopt and implement over the last few months of the year 2022 the new business strategy to focus on discovery research in areas of expertise where it can leverage the differentiated nature of its platforms;

• The increase on IP filing and maintenance fees in line with the new business strategy which has been adopted and implemented over the last few months of the year 2022 to focus on maximizing the Group's intellectual property (IP) portfolio;

• The decrease of the expenses associated with the share-based payments (non-cash expenses) related to the warrants plan offered to the employees, managers and directors, mainly related to the decrease in the fair market value of stock options issued in 2022; and

• The decrease of process development costs after the Group's decision to adopt and implement over the last few months of the year 2022 the new business strategy to focus on discovery research and discontinue the development of clinical programs.

Research and development expenses totaled €20.8 million for the year ended December 31, 2021, which represented a decrease of 3% compared to 2020. The Group's R&D internal resources are allocated to the continuous development of its immuno-oncology platform mainly in allogenic setting with its products candidate CYAD-101, CYAD-211 and preclinical programs (such as CYAD-203). The decrease in the Group's R&D expenses was primarily driven by:

• The increase of employee expenses mainly related to movement of employees through the year ended December 31, 2021 to support the Group's preclinical and clinical programs

• The increase of preclinical activities associated with the CYAD-203 program (next-generation NKG2D) and other next-generation CAR T candidates, compensated by;

• The decrease of process development and clinical development after the Group's decision in the fourth quarter of 2020 to discontinue the development of first-generation, autologous CAR T candidate CYAD-01;

• The decrease of process development associated to the transition from preclinical to clinical development of the CYAD-211 program; and

• The decrease of the expenses associated with the share-based payments (non-cash expenses) related to the warrants plan offered to our employees, managers and directors , mainly related to the decrease in the fair market value of stock options issued in 2022.

------

General and administrative expenses

---

| | | | |
|:---|:---|:---|:---|
| (€'000) | For the year ended December 31, | For the year ended December 31, | For the year ended December 31, |
|  | 2022 | 2021 | 2020 |
| Employee expenses | 3 801 | 3 575 | 3 363 |
| Consulting fees | 2 870 | 2 254 | 1 747 |
| Insurances | 1 967 | 1 642 | 1 182 |
| Share-based payments | 1 199 | 1 529 | 1 855 |
| Communication & Marketing | 239 | 434 | 454 |
| Depreciation | 209 | 243 | 320 |
| Travel & Living | 115 | 31 | 91 |
| Rent | 109 | 50 | 87 |
| Post-employment benefits | (55) | (7) | 19 |
| Other | 92 | 157 | 197 |
| Total General and administration | 10 546 | 9 908 | 9 315 |

---

General and Administrative expenses increased by €0.6 million over the year ended December 31, 2022, which represents an increase of 6.4% compared to 2021. The increase in insurances costs (D&O insurance principally) and consulting fees associated with legal and capital raise opportunities have been partially offset by the decrease of expenses associated with share-based payments (non-cash expenses) related to the warrants plan offered to the employees, managers and directors, mainly related to the decrease in the fair market value of stock options issued in 2022.

General and administrative expenses increased by €0.6 million over the year ended December 31, 2021, which represented an increase of 6.4% compared to 2020. The increase in insurances costs (D&O insurance principally) and consulting fees associated with legal, recruitment and capital raise opportunities had been partially compensated by the decrease of the expenses associated with the share-based payments (non-cash expenses) related to the warrants plan offered to the Group's employees, managers and directors.

NOTE 27: EMPLOYEE BENEFIT EXPENSES

As of December 31, 2022, we employed 28 full-time employees, 3 part-time employees, 7 members of the Executive Committee (among them 3 are under management services agreement), and 1 manager under management services agreements. We have never had a work stoppage We consider our relationship with our employees to be good.

---

| | | | |
|:---|:---|:---|:---|
| (€'000) | For the year ended December 31, | For the year ended December 31, | For the year ended December 31, |
|  | 2022 | 2021 | 2020 |
| Salaries, wages and fees | 7 470 | 7 975 | 7 139 |
| Executive Committee compensation | 3 599 | 3 115 | 2 773 |
| Share-based payments | 1 624 | 2 172 | 2 782 |
| Social security | 1 237 | 1 444 | 1 487 |
| Post-employment benefits | 147 | 251 | 263 |
| Hospitalization insurance | 226 | 142 | 146 |
| Other benefit expense | 128 | 116 | 138 |
| Total Employee expenses | 14 432 | 15 215 | 14 727 |

---

Total employee expenses decreased in 2022 compared to 2021. Salaries, wages and fees expenses decreased compared to 2021, which reflects the impact of the reorganization of the Group (including one-off expenses), consistent with a total staff full time equivalent ("FTE") reduction of 16.6% for the year 2022. The increase of the Executive Committee compensation is due to the its reorganization through the year 2022 (including one-offs expenses) which is compensated by the decrease of the expenses associated with the share-based payments (non-cash expenses) related to the warrants plan offered to the employees, managers and directors, mainly related to the decrease in the fair market value of stock options issued in 2022.

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Total employee expenses increased in 2021 compared to 2020. Salaries, wages and fees expenses show a net increase year-on-year, which reflects the organic growth of the Group, in line with a total staff FTE increased by 14.2% at December 31, 2021.

---

| | | | |
|:---|:---|:---|:---|
| Staff full time equivalent ("FTE") | For the year ended December 31, | For the year ended December 31, | For the year ended December 31, |
|  | 2022 | 2021 | 2020 |
| Research & Development | 82.6 | 94.1 | 81.7 |
| General and Administration | 11.0 | 18.2 | 16.6 |
| Total Staff FTE | 93.6 | 112.3 | 98.3 |

---

NOTE 28: OTHER INCOME AND OTHER EXPENSES

Other income

---

| | | | |
|:---|:---|:---|:---|
| (€'000) | For the year ended December 31, | For the year ended December 31, | For the year ended December 31, |
|  | 2022 | 2021 | 2020 |
| Grant income (RCA's) | 1 137 | 2 731 | 2 311 |
| Grant income (Other) | 910 | 1 448 | 779 |
| Remeasurement of RCA's | 1 447 |  | 933 |
| R&D tax credit | 462 | 687 | 657 |
| Gain on sale of CTMU activities | 5 187 |  |  |
| Gain on sales of Property, plant & equipment |  |  | 35 |
| Remeasurement of Leases | 169 |  |  |
| Other | 48 | 43 | 17 |
| Total Other Income | 9 360 | 4 909 | 4 731 |

---

In 2022, other income is mainly related to:

• Grant income (RCAs): additional grant income has been recognized in 2022 on grants in the form of recoverable cash advances (RCAs) for contracts numbered 8212, 8436 and 1910028. In accordance with IFRS standards, the Company has earned grants for the period amounting to € 1.6 million, out of which € 0.5 million is accounted for as a financial liability (see notes 19 and 24) and the remaining € 1.1 million as a grant income. The decrease compared to December 31, 2021 is mainly associated with the decrease on additional grant income recognized on these conventions due to advancement of the subsidized programs;

• The remeasurement income on the recoverable cash advances (RCAs) of €1.4 million for the year 2022 is mainly related to the Group decision to discontinue its remaining clinical programs (see note 24), while the remeasurement on the recoverable cash advances (RCAs) was an expense for the year ended December 31, 2021;

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• Grant income (Others): additional grant income has been recognized in 2022 on grants received from the regional government (contract numbered 8516), not referring to RCAs and not subject to reimbursement. The decrease compared to December 31, 2021 is mainly due to grant income recognized on grants received from the Federal Belgian Institute for Health Insurance Inami (€0.3 million) for which no revenue has been recognized in 2022 and from the regional government (contracts numbered 8066 and 8516 for €1.1 million) as the convention 8066 has been closed in 2021;

• R&D tax credit: the current year income decreased compared to December 31, 2021 due to lower eligible expenses on clinical activities and prioritization of discovery research in areas of expertise where it can leverage the differentiated nature of the Group's platforms;

• Gain on sale of CTMU activities results from the terms of the asset purchase agreement between Celyad Oncology and Cellistic under which Cellistic agreed to acquire Celyad Oncology's Manufacturing Business Unit for a total consideration of € 6.0 million (see note 5.1). The book value of assets sold to Cellistic was € 0.6 million (see note 5.7) and allocated goodwill totaled € 0.2 million (see note 5.6.1); and

• Remeasurement of leases: results from the difference between the decrease in the lease liability and the decrease in the right-of-use asset both primarily driven by the termination of leases associated to CTMU facilities and the termination of the current lease associated to the corporate offices before their relocation in 2023.

In 2021, other income was mainly related to:

• Grant income (RCAs): additional grant income had been recognized in 2021 on grants in the form of recoverable cash advances (RCAs) for contracts numbered 8087, 8088, 8212, 8436 and 1910028. According to IFRS standards, the Company had earned grants for the period amounting to €2.7 million and a liability component of €1.6 million was accounted for as a financial liability. The increase compared to December 31, 2020 is mainly associated with additional grant income recognized on new conventions signed during the last quarter of 2020 (contracts numbered 8212 and 8436) and on convention numbered 1910028, partly compensated by the decrease on grant income recognized on conventions associated to autologous programs (contract numbered 7685, 8087 and 8088);

• Grant income (Others): additional grant income had been recognized in 2021 on grants received from the Federal Belgian Institute for Health Insurance Inami (€0.3 million) and from the regional government (contracts numbered 8066 and 8516 for €1.1 million), not referring to RCAs and not subject to reimbursement. The increase compared to December 31, 2020 was mainly due to grant income recognized on new convention signed in the last quarter of 2021 with the regional government (contract numbered 8516);

• the remeasurement income on the recoverable cash advances (RCAs) of €0.9 million for the year 2020, which had been mainly related to the Group decision to update assumptions associated with the timing of the potential commercialization of the Group's autologous AML/MDS CAR T program, while the remeasurement on the recoverable cash advances (RCAs) was an expense for the year ended December 31, 2021; and

• with respect to R&D tax credit, the income was predicated on a R&D tax credit recorded (€0.7 million), which had been updated taking into account all information available at this date and was in line with previous year.

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Other expenses

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| | | | |
|:---|:---|:---|:---|
| (€'000) | For the year ended December 31, | For the year ended December 31, | For the year ended December 31, |
|  | 2022 | 2021 | 2020 |
| Clinical Development milestone payment |  |  | 69 |
| Remeasurement of RCA's |  | 328 |  |
| Loss on disposals of Property, plant & equipment | 132 | 1 | 10 |
| Loss on disposals of Intangible assets | 58 |  |  |
| Amendment fees on license agreement |  | 1 104 |  |
| Other | 149 | 33 | 35 |
| Total Other Expenses | 339 | 1 466 | 114 |

---

As of December 31, 2022, the decrease of other expenses compared to December 31, 2021, is mainly related to the amendment fees on license agreement with Dartmouth for €1.1 million in 2021, while there has been no such amendment in 2022.

For the year ended December 31, 2020, other expenses had mainly referred to clinical development milestones for (€0.1 million) paid to Dartmouth after that the Group successfully dosed the first patient with CYAD-02 in CYCLE-1 trial for r/r AML and MDS treatment.

NOTE 29: CHANGE IN FAIR VALUE OF CONTINGENT CONSIDERATION AND IMPAIRMENT OF ONCOLOGY INTANGIBLE ASSETS

Change in fair value of contingent consideration

---

| | | | |
|:---|:---|:---|:---|
| (€'000) | For the year ended December 31, | For the year ended December 31, | For the year ended December 31, |
|  | 2022 | 2021 | 2020 |
| Change in fair value of contingent consideration | 14 679 | 847 | 9 228 |
| Total Change in fair value of contingent consideration | 14 679 | 847 | 9 228 |

---

The fair value adjustment (€14.7 million, non-cash expenses) relates to the reassessment as of December 31, 2022, of the contingent consideration and other financial payable related to the potential future payments to Celdara Medical, LLC and Dartmouth College associated with the Group's immuno-oncology platform. For further details regarding the change in fair value of contingent consideration, refer to note 23.

The fair value adjustment (€0.8 million, non-cash expenses) relating to reassessment as of December 31, 2021, was mainly driven by:

• The update of the assumptions associated with the timing of the potential commercialization of the Group's allogenic CYAD -101 CAR T program for mCRC which has been delayed by one year;

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• The update of the assumptions associated with the timing, development and the potential commercialization of the Group's autologous CYAD-02 CAR T program for r/r AML/MDS to reflect the future development of the program through potential partnership, which has been delayed by one year;

• The update in WACC used for fair value measurement purposes at December 31, 2021;

• The revaluation of the U.S. dollar against the Euro; and

• The updated assumptions on Probability of Success (PoS) associated with the Group's CAR T programs.

As of December 31, 2020, the change in fair value of the contingent consideration and other financial liabilities was mainly driven by updated assumptions associated with the timing of the potential commercialization of the Company's autologous AML/MDS CAR T program which had been delayed by one year.

Impairment of Oncology intangible assets

---

| | | | |
|:---|:---|:---|:---|
| (€'000) | For the year ended December 31, | For the year ended December 31, | For the year ended December 31, |
|  | 2022 | 2021 | 2020 |
| Impairment of Oncology intangible assets | (35 084) |  |  |
| Total Impairment of Oncology intangible assets | (35 084) |  |  |

---

Management performed an annual impairment test on goodwill and on 'indefinite lived assets' that are not amortized in accordance with the accounting policies stated in note 3. The impairment test has been performed at the level of the immuno-oncology segment corresponding to the CGU to which the goodwill and the IPR&D belong as well as the Horizon Discovery's shRNA platform. For further details regarding the impairment of oncology intangible assets for the year ended December 31, 2022, refer to note 7.

NOTE 30: LEASES

Amounts recognized in the consolidated statements of financial position

---

| | | |
|:---|:---|:---|
| (€'000) | As at December 31, | As at December 31, |
|  | 2022 | 2021 |
| Property, Plant and Equipment owned (excluding right-of-use assets) | 86 | 1 033 |
| Right-of-use assets | 223 | 2 215 |
| Total Property, Plant and Equipment | 309 | 3 248 |

---

The consolidated statements of financial position shows the following amounts relating to leases for which the Group is a lessee:

---

| | | | | |
|:---|:---|:---|:---|:---|
| (€'000) | Property | Vehicles | Equipment | Total |
| Cost |  |  |  |  |
| At January 1, 2021 | 3 001 | 429 | 1 491 | 4 920 |
| Additions | 24 | 67 |  | 91 |
| Disposals |  | (41) |  | (41) |
| Transfers |  |  | (950) | (950) |
| At December 31, 2021 | 3 025 | 454 | 541 | 4 020 |
| Additions | 146 | 7 |  | 153 |
| Disposals | (3 171) | (131) |  | (41) |

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------

---

| | | | | |
|:---|:---|:---|:---|:---|
| At December 31, 2022 |  | 331 | 541 | 872 |
| Accumulated depreciation |  |  |  |  |
| At January 1, 2021 | (827) | (165) | (924) | (1 916) |
| Depreciation charge | (454) | (117) | (309) | (880) |
| Disposals |  | 41 |  | 41 |
| Transfers |  |  | 950 | 950 |
| At December 31, 2021 | (1 281) | (241) | (283) | (1 805) |
| Depreciation charge | (439) | (105) | (118) | (663) |
| Disposals | 1 721 | 98 |  | 1 819 |
| At December 31, 2022 |  | (248) | (401) | (649) |
| Net book value |  |  |  |  |
| Cost | 3 025 | 454 | 541 | 4 020 |
| Accumulated depreciation | (1 281) | (241) | (283) | (1 805) |
| At December 31, 2021 | 1 744 | 213 | 258 | 2 215 |
| Cost |  | 331 | 541 | 872 |
| Accumulated depreciation |  | (248) | (401) | (649) |
| At December 31, 2022 |  | 83 | 140 | 223 |

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The disposals for the year 2022 are mainly related to the termination of the lease agreement associated to the CTMU facilities and the termination of the lease agreement for current corporate offices before their relocation in 2023. See note 8.

Amounts recognized in the consolidated statements of comprehensive loss

The consolidated statements of comprehensive loss show the following amounts relating to leases:

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| | | | |
|:---|:---|:---|:---|
| (€'000) | For the 12-month period ended December 31, | For the 12-month period ended December 31, | For the 12-month period ended December 31, |
|  | 2022 | 2021 | 2020 |
| Depreciation charge of right-of-use assets |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Property | 439 | 454 | 428 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Vehicles | 105 | 76 | 75 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Equipment | 118 | 309 | 567 |
| Interest on lease liabilities (including in Financial expenses)<sup>1</sup> | 150 | 217 | 259 |
| Interest on sublease receivable (including in Financial income)<sup>1</sup> | (11) | (26) | (46) |
| Variable lease payments not included in the measurement of lease liabilities |  |  |  |
| Remeasurement of Leases | (169) |  |  |
| Expenses relating to short-term leases and leases of low-value assets | 126 | 137 | 166 |
| Total expenses related to leases | 758 | 1 167 | 1 449 |

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<sup>1</sup> Interests on leases are presented as operating cash flow.

The net income from the remeasurement of leases primarily results from termination of leases associated to CTMU facilities and the termination of the current lease associated to the corporate offices before their relocation in 2023.

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Total cash outflow for leases

---

| | | | |
|:---|:---|:---|:---|
| (€'000) | For the 12-month period ended December 31, | For the 12-month period ended December 31, | For the 12-month period ended December 31, |
|  | 2022 | 2021 | 2020 |
| Total cash outflow for leases | 1 172 | 1 453 | 1 681 |

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NOTE 31: FINANCIAL INCOME AND EXPENSES

---

| | | | |
|:---|:---|:---|:---|
| (€'000) | For the year ended December 31, | For the year ended December 31, | For the year ended December 31, |
|  | 2022 | 2021 | 2020 |
| Interest finance leases | 150 | 217 | 260 |
| Interest on overdrafts and other finance costs | 33 | 21 | 19 |
| Interest on RCAs | 14 | 17 | 18 |
| Foreign Exchange differences |  |  | 136 |
| Finance expenses | 198 | 255 | 434 |
| Finance income on the net investment in lease | 11 | 26 | 46 |
| Interest income bank account | 1 | 1 | 5 |
| Foreign Exchange differences | 173 | 5 |  |
| Other financial income |  | 112 | 166 |
| Finance income | 185 | 144 | 217 |
| Net Financial result | (13) | (111) | (217) |

---

The net financial result increased from a net financial loss of €0.1 million for the year ended December 31, 2021 to €0.0 million of net financial loss for the year ended December 31, 2022, which is mainly driven by the increase of gain on foreign exchange differences for €0.2 million due to the revaluation of the USD through the year ended December 31, 2022 partly compensated by the decrease of interest expenses on finance leases for €0.1 million mainly due to termination of leases which occurred through the year 2022.

The net financial result had increased from a net financial loss of €0.2 million for the year ended December 31, 2020 to €0.1 million of net financial loss for the year ended December 31, 2021, which was mainly driven by the decrease from €0.1 million of loss on foreign exchange differences due to the revaluation of the USD through the year ended December 31, 2021 and its impact on the valuation of the Mesoblast receivable.

NOTE 32: INCOME TAX

The Group reports income taxes in the income statement as detailed below:

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| | | | |
|:---|:---|:---|:---|
| (€'000) | For the year ended December 31, | For the year ended December 31, | For the year ended December 31, |
|  | 2022 | 2021 | 2020 |
| Current tax (expense) / income | (65) | (10) |  |
| Deferred tax (expense) / income |  |  |  |
| Total income tax expense in profit or loss | (65) | (10) |  |

---

The Group has a history of losses.

The following table shows the reconciliation between the effective and theoretical income tax at the nominal Belgian income tax rate of 25.00% for the years 2022, 2021 and 2020:

------

---

| | | | |
|:---|:---|:---|:---|
| (€'000) | For the year ended December 31, | For the year ended December 31, | For the year ended December 31, |
|  | 2022 | 2021 | 2020 |
| Loss before tax | (40 870) | (26 502) | (17 204) |
| Permanent differences |  |  |  |
| Tax disallowed expenses | 1 248 | 1 185 | 1 092 |
| Share-based payment | 1 624 | 2 172 | 2 782 |
| Nominal tax rate | 25.00% | 25.00% | 25.00% |
| Income tax at nominal tax rate<sup>1</sup> | 9 500 | 5 786 | 3 333 |
| Deferred tax assets not recognized | (9 565) | (5 796) | (3 333) |
| Effective tax expense | (65) | (10) |  |
| Effective tax rate | 0% | 0% | 0% |

---

<sup>1</sup> The difference in foreign tax rate in the US (25.80%) compared to the Belgian rate (25.00%) is not distinctively disclosed in this table due to non-materiality of the operations of the Group's subsidiary Celyad Inc. 

NOTE 33: DEFERRED TAXES

As having not yet reached the commercialization step, the Group accumulates tax losses that are carried forward indefinitely for offset against future taxable profits of the Group. Significant uncertainty exists however surrounding the Group's ability to realize taxable profits in a foreseeable future leading the Group to not recognizing any net deferred tax assets in its statements of financial position.

Deferred tax assets and liabilities are detailed below by nature of temporary differences for the current year:

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| | | | |
|:---|:---|:---|:---|
| (€'000) | For the year ended | For the year ended | For the year ended |
|  | December 31, 2022 | December 31, 2022 | December 31, 2022 |
|  | Assets | Liabilities | Net |
| Intangibles assets |  | (216) | (216) |
| Recoverable cash advances liability | 1 226 |  | 1 226 |
| Contingent consideration liability |  |  |  |
| Employee Benefits liability | 3 |  | 3 |
| Other temporary difference | 272 |  | 272 |
| Tax-losses carried forward | 78 332 |  | 78 332 |
| Unrecognized Gross Deferred Tax assets/(liabilities) | 79 833 | (216) | 79 617 |
| Netting by tax entity | (216) | 216 |  |
| Unrecognized Net Deferred Tax assets/(liabilities) | 79 617 |  | 79 617 |

---

Deferred tax assets and liabilities are detailed below by nature of temporary differences for the prior year:

---

| | | | |
|:---|:---|:---|:---|
| (€'000) | For the year ended | For the year ended | For the year ended |
|  | December 31, 2021 | December 31, 2021 | December 31, 2021 |
|  | Assets | Liabilities | Net |
| Intangibles assets |  | (2 709) | (2 709) |
| Recoverable cash advances liability | 1 503 |  | 1 503 |
| Contingent consideration liability | 3 670 |  | 3 670 |
| Employee Benefits liability | 13 |  | 13 |
| Other temporary difference |  | (586) | (586) |
| Tax-losses carried forward | 72 671 |  | 72 671 |
| Unrecognized Gross Deferred Tax assets/(liabilities) | 77 857 | (3 295) | 74 562 |
| Netting by tax entity | (3 295) | 3 295 |  |
| Unrecognized Net Deferred Tax assets/(liabilities) | 74 562 |  | 74 562 |

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The Group's main deductible tax base relates to tax losses carried forward, which have indefinite term under both BE and US tax regimes applicable to its subsidiaries.

The remaining temporary differences refer to differences between IFRS accounting policies and local tax reporting policies.

The change in the Group's net deferred tax asset balance is detailed below:

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| | | | |
|:---|:---|:---|:---|
| UNRECOGNIZED DEFERRED TAX ASSET BALANCE ROLL FORWARD | UNRECOGNIZED DEFERRED TAX ASSET BALANCE ROLL FORWARD | UNRECOGNIZED DEFERRED TAX ASSET BALANCE ROLL FORWARD | UNRECOGNIZED DEFERRED TAX ASSET BALANCE ROLL FORWARD |
| (€'000) | For the year ended | For the year ended | For the year ended |
|  | 2022 | 2021 | 2020 |
| Opening balance at January 1, | 74 562 | 66 208 | 61 300 |
| Temporary difference creation or reversal | (606) | (1 014) | (2 981) |
| Change in Tax-losses carried forward | 5 661 | 8 820 | 8 064 |
| Change in US tax rate applicable |  | 548 | (176) |
| Closing balance at December 31, | 79 617 | 74 562 | 66 208 |

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The net increase in the balance mainly relates to the additional losses reported for the current year.

As of December 31, 2022, the Group has a total accumulated tax losses of €312.9 million, which generate unrecognized deferred tax assets, not subject to expiration.

NOTE 34: COMMITMENTS

Celdara

Background

In January 2015, the Group entered into an agreement with Celdara Medical, LLC, or Celdara in which the Group purchased all outstanding membership interests of OnCyte, LLC, or OnCyte. In connection with this transaction, the Group entered into an asset purchase agreement to which Celdara sold to OnCyte certain data, protocols, regulatory documents and intellectual property, including the rights and obligations under two license agreements between OnCyte and The Trustees of Dartmouth College, or Dartmouth, related to the Group's CAR T development programs.

In March 2018, the Group dissolved the affairs of its wholly owned subsidiary OnCyte. As a result of the dissolution of OnCyte, all the assets and liabilities of OnCyte were fully distributed to the Group including its license agreement with Dartmouth.

Amended Asset Purchase Agreement

In August 2017, the Group entered into an amendment to the asset purchase agreement described above. In connection with the amendment, the following payments were made to Celdara: (i) an amount in cash equal to $10.5 million, (ii) newly issued shares of Celyad valued at $12.5 million, (iii) an amount in cash equal to $6.0 million in full satisfaction of any payments owed to Celdara in connection with a clinical milestone related to the Group's CAR-T NKR-2 product candidate, (iv) an amount in cash equal to $0.6 million in full satisfaction of any payments owed to Celdara in connection with the Group's license agreement with Novartis International Pharmaceutical Ltd., and (v) an amount in cash equal to $0.9 million in full satisfaction of any payments owed to Celdara in connection with the Group's former license agreement with Ono Pharmaceutical Co., Ltd.

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Under the amended asset purchase agreement, the Group is obligated to make certain development-based milestone payments to Celdara up to $40.0 million, certain development-based milestone payments up to $36.5 million and certain sales-based milestone payments up to $156.0 million. The Group is required to make tiered single-digit royalty payments to Celdara in connection with the sales of CAR-T products, subject to reduction in countries in which there is no patent coverage for the applicable product or in the event Celyad is required to secure licenses from third parties to commercialize the applicable product. The Group is also required to pay Celdara a percentage of sublicense income, including royalty payments, for each sublicense ranging from the mid-single digits to the mid-twenties, depending on which of a specified list of clinical and regulatory milestones the applicable product has achieved at the time the sublicense is executed. The Group is required to pay Celdara a single-digit percentage of any research and development funding received by us, not to exceed $7.5 million for each product group. The Group can opt out of the development of any product if the data does not meet the scientific criteria of success. The Group may also opt out of development of any product for any other reason upon payment of a termination fee of $2.0 million to Celdara.

The Trustees of Dartmouth College ("Dartmouth")

As described above, as a result of the Group's acquisition of all of the outstanding membership interests of OnCyte and the asset purchase agreement among the Group, Celdara and OnCyte, OnCyte became the Group's wholly-owned subsidiary and acquired certain data, protocols, regulatory documents and intellectual property, including the rights and obligations under two license agreements between OnCyte and Dartmouth. The first of these two license agreements concerned patent rights related, in part, to methods for treating cancer involving chimeric NK and NKP30 receptor targeted therapeutics and T cell receptor-deficient T cell compositions in treating tumor, infection, GVHD, transplant and radiation sickness, or the CAR-T License, and the second of these two license agreements concerned patent rights related, in part, to anti-B7-H6 antibody, fusion proteins and methods of using the same, or the B7H6 License.

In August 2017, the Group and Dartmouth entered into an amendment agreement in order to combine its rights under B7H6 Agreement with its rights under the CAR-T License, resulting in the termination of the B7H6 License, and in order to make certain other changes to the agreement. In connection with the amendment, the Group paid Dartmouth a non-refundable, non-creditable amendment fee in the amount of $2.0 million in 2017. Under the amended license agreement, Dartmouth granted the Group an exclusive, worldwide, royalty-bearing license to certain know-how and patent rights to make, have made, use, offer for sale, sell, import and commercialize any product or process for human therapeutics, the manufacture, use or sale of which, is covered by such patent rights or any platform product. Dartmouth reserves the right to use the licensed patent rights and licensed know-how, in the same field, for education and research purposes only. The patent rights included in the amended license agreement also include the patents previously covered by the B7H6 License. In consideration for the rights granted to the Group under the amended license agreement, the Group is required to pay to Dartmouth an annual license fee as well as a low single-digit royalty based on annual net sales of the licensed products by the Group, with certain minimum net sales obligations beginning April 30, 2024 and continuing for each year of sales thereafter. Under the amended license agreement, in lieu of royalties previously payable on sales by sublicensees, the Group is required to pay Dartmouth a percentage of sublicense income, including royalty payments, (i) for each product sublicense ranging from the mid-single digits to low-single digits, depending on which of a specified list of clinical and regulatory milestones the applicable product has achieved at the time the sublicense is executed and (ii) for each platform sublicense in the mid-single digits. Additionally, the agreement requires that the Group exploits the licensed products, and the Group has agreed to meet certain developmental and regulatory milestones. Upon successful completion of such milestones, the Group is obligated to pay to Dartmouth certain clinical and regulatory milestone payments up to an aggregate amount of $1.5 million and a commercial milestone payment in the amount of $4.0 million. The Group is responsible for all expenses in connection with the preparation, filing, prosecution and maintenance of the patents covered under the agreement.

As further amended in December 2021, this agreement allows Dartmouth to terminate the amended license after April 30, 2026, extended from the prior date of April 30, 2024, in the event that Celyad fails to meet the specified minimum net sales obligations for any year ($10 million during first year of sales, $40 million during the second year of sales and $100 million during the third year of sales and every year of sales thereafter), unless Celyad pays to Dartmouth the royalty Celyad would otherwise be obligated to pay had Celyad met such minimum net sales obligation. Dartmouth may also terminate the license if Celyad fails to meet a milestone within the specified time period, unless Celyad pays the corresponding milestone payment. In connection with the December 2021 amendment, the Group agreed to certain protective provisions of any sublicenses and paid Dartmouth a non-refundable, non-creditable amendment fee and an additional non-refundable, non-creditable sublicense fee to be paid on an annual basis.

------

In accordance with IFRS 3, these contingencies are recognized on the statement of financial position at year-end, on a risk-adjusted basis.

Horizon Discovery / PerkinElmer

In April and June 2018, the Group signed two research and development collaboration and license agreements with Horizon Discovery Group plc, or Horizon, to evaluate the utility of Horizon's SMART vector shRNA reagents to reduce expression of one or more defined targets in connection with the development of the Group's product candidates. The first agreement was focused on targets related to its autologous CAR-T candidate, CYAD-02. The second agreement was focused on targets related to its allogenic CAR-T product candidate CYAD-211 and one pre-clinical allogenic product candidate not yet publicly announced, called CYAD-203.

In December 2018, the Group exercised its option to convert the second agreement into an exclusive license agreement, in connection with which the Group paid Horizon an up-front payment of $1 million. In September 2019, the Group exercised its option to convert the first agreement into an exclusive license agreement, in connection with which the Group has paid Horizon an up-front payment of $0.1 million and an additional milestone of $0.1 million for the first IND filed by us for CYAD-02. In September 2020, the Group paid an additional milestone of $0.2 million for the first IND filed by the Group for CYAD-211.

Under these exclusive license agreements combined, Horizon is eligible to receive additional milestone payments in development, regulatory and commercial milestone payments, in addition to low single digit royalties on net sales, subject to customary reductions.

In December 2020, Horizon Discovery was acquired by PerkinElmer, Inc. (Horizon/PKI).

In 2021, Horizon/PKI informed the Group they believe the Group is in material breach of these agreements as a result of certain disclosures the Group has made in connection with its obligations as a publicly traded company in the United States and Belgium, although they have not formally delivered to the Group a notice of material breach or termination. The Group believes any such assertion of material breach would be without merit and the Group would expect to vigorously defend any such notice of material breach. Any dispute under these agreements would be subject to arbitration in The Hague under the International Chamber of Commerce Rules. The Group is currently in discussions with Horizon about possible amendments to these agreements in connection with which the Group would retain freedom to operate under the in-licensed patents.

Of note, the Group has filed patent applications which, if issued, would cover other aspects of the product candidates described above as well as products developed by third parties that deploy similar technology and targets. These patent applications encompass the downregulation of one or more of the targets covered under the Horizon/PKI agreements, the use of shRNA to downregulate such targets in immune cells and the combination of shRNAs with a chimeric antigen receptor in immune cells. The Group is also developing a second generation shRNA platform that does not incorporate any of the Horizon Discovery/Perkin Elmer, Inc. technology described above.

The Group's discontinued allogeneic CAR T product candidate, CYAD-101, does not incorporate any of the Horizon Discovery/Perkin Elmer, Inc. technology described above.

Other commitments

In 2021, the Group signed two license agreements. Under these license agreements, the licensors are eligible to receive additional milestone payments in development, regulatory and commercial milestone payments, in addition to low single digit royalties on net sales, subject to customary reductions, if the Group decided to continue the exploitation of these licenses. In 2022, the Group decides to stop the exploitation of these two licenses (see note 7).

The Group has entered into a lease agreement for its new head quarter (Dumont 9 building in Mont-Saint-Guibert, Belgium) for total undiscounted lease payment of €0.5 million. This lease will commence from April 1, 2023. During the time needed for the set-up of its new offices of Dumont 9 building, we execute short term lease (less than 12 months) of a part of Belin 2 building from Cellistic for €0.3 million.

------

NOTE 35: RELATIONSHIPS WITH RELATED PARTIES

Remuneration of key management

Key management consists of the members of the Executive Committee and the entities controlled by any of them.

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | As at December 31, | As at December 31, | As at December 31, | As at December 31, | As at December 31, | As at December 31, |
|  | 2022 | 2022 | 2021 | 2021 | 2020 | 2020 |
| Number of Executive Committee members |  | 7 |  | 7 |  | 6 |

---

---

| | | | |
|:---|:---|:---|:---|
| (€'000) | For the year ended<br> December 31, | For the year ended<br> December 31, | For the year ended<br> December 31, |
|  | 2022 | 2021 | 2020 |
| Short term employee benefits<sup>[1]</sup> | 2 294 | 1 866 | 1 349 |
| Post employee benefits | 53 | 45 | 34 |
| Share-based compensation | 790 | 928 | 1 110 |
| Other employment costs<sup>[2]</sup> | 143 | 148 | 110 |
| Management fees | 1 200 | 1 163 | 1 335 |
| Total benefits | 4 480 | 4 150 | 3 939 |
| Executive Committee outstanding fees payables | 781 | 844 | 660 |

---

(1) Include salaries, social security, bonuses, lunch vouchers

(2) Company cars

The increase of the short term employees benefits as of December 31, 2022, include the one-off expenses due to the reorganization of the Executive Committee through the year 2022.

---

| | | | |
|:---|:---|:---|:---|
|  | As at December 31, | As at December 31, | As at December 31, |
|  | 2022 | 2021 | 2020 |
| Number of warrants granted | 489 700 | 395 000 | 220 000 |
| Number of warrants lapsed | (127 250) | (30 000) | (20 000) |
| Cumulative outstanding warrants | 696 400 | 921 000 | 556 000 |
| Exercised warrants |  |  |  |

---

Transactions with non-executive directors

---

| | | | |
|:---|:---|:---|:---|
|  | For the year ended December 31, | For the year ended December 31, | For the year ended December 31, |
| (€'000) | 2022 | 2021 | 2020 |
| Share-based compensation | 230 | 337 | 396 |
| Management fees | 382 | 373 | 366 |
| Total benefits | 612 | 710 | 762 |
| Non-executive directors outstanding fees payables | 93 | 93 | 94 |

---

---

| | | | |
|:---|:---|:---|:---|
|  | As at December 31, | As at December 31, | As at December 31, |
|  | 2022 | 2021 | 2020 |
| Number of warrants granted | 40 000 | 150 000 | 80 000 |
| Number of warrants lapsed | (60 000) |  | (30 000) |
| Number of exercised warrants |  |  |  |
| Cumulative outstanding warrants | 230 000 | 340 000 | 220 000 |

---

------

Transactions with shareholders

There were no transactions with the Group's shareholders, for 2022, 2021 or 2020.

NOTE 36: LOSS PER SHARE

The loss per share is calculated by dividing loss for the year by the weighted average number of ordinary shares outstanding during the period. As the Group is incurring net losses, all of the outstanding warrants have an anti-dilutive effect. As such, there is no difference between the basic and the diluted earnings per share. In case the warrants would be included in the calculation of the loss per share, this would decrease the loss per share.

---

| | | | |
|:---|:---|:---|:---|
| (€'000) | As at December 31, | As at December 31, | As at December 31, |
|  | 2022 | 2021 | 2020 |
| Loss of the year attributable to Equity Holders | (40 935) | (26 512) | (17 204) |
| Weighted average number of shares outstanding | 22 593 956 | 15 604 014 | 13 942 344 |
| Earnings per share (non-fully diluted) in € | (1.81) | (1.70) | (1.23) |
| Outstanding warrants | 2 339 646 | 2 136 556 | 1 488 006 |

---

#### NOTE 37: EVENTS AFTER THE CLOSE OF THE FISCAL YEAR
On January 1, 2023, the Company sold all the leasehold improvements, and furniture associated to the Group's corporate offices located at Rue Edouard Belin 2, 1435 Mont-Saint-Guibert, Belgium, for a total value of €1.3 million. The Company will use part of this money to refurbish and move to its new facility located at Rue Dumont 9, 1435 Mont-Saint-Guibert, Belgium. The move to these new spaces is expected in the fourth quarter of 2023. As from January 1, 2023, until the date the Company moves into the new corporate offices (Dumont 9), the Company leases its current facilities (Belin, 2) from Cellistic, under a new lease contract (see note 34).

Effective January 9, 2023, the clinical team (8 employees) has joined the organization of ProPharma Group Holdings LLC, a global reputed CRO with whom Celyad has simultaneously entered into a service agreement for support relating to the closing of its clinical trials. The clinical trials remain under the Company responsibility as sponsor, while the clinical workforce has been transferred to said partner to secure a seamless closing of the clinical studies, preserving the best interests of the patients and investigational sites.

There were no other subsequent events that have occurred between year-end and the date when the financial statements were authorized by the Board for issue.

------

##### [**Table of Contents**](#toc)

#### EXHIBIT INDEX

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | | **Incorporated by Reference** | **Incorporated by Reference** | **Incorporated by Reference** | **Incorporated by Reference** |
| <br>**Exhibit** | <br>**Description** | **Schedule/**<br> **Form** | **File**<br> **Number** | **Exhibit** | **File**<br> **Date** |
| 1.1\* | [Articles of Association (English translation)](d418841dex11.htm) |  |  |  |  |
| 2.1 | [Form of Deposit Agreement](http://www.sec.gov/Archives/edgar/data/1637890/000119312515222438/d893510dex41.htm) | F-1/A | 333-204251 | 4.1 | 6-15-2015 |
| 2.2 | [Form of American Depositary Receipt](http://www.sec.gov/Archives/edgar/data/1637890/000119380518001228/e617988_424b3-celyad.htm) | 424(b)(3) | 333-204724 | N/A | 10-15-2018 |
| 2.3 | [Description of Securities](http://www.sec.gov/Archives/edgar/data/1637890/000119312520084305/d861749dex23.htm) | 20-F | 001-37452 | 2.3 | 3-25-2020 |
| 4.1 | [Exclusive License Agreement, dated April 30, 2010, between the Trustees of Dartmouth College and Celdara Medical, LLC, as amended](http://www.sec.gov/Archives/edgar/data/1637890/000119312515191674/d893510dex109.htm) | F-1 | 333-204251 | 10.9 | 5-18-2015 |
| 4.2 | [Exclusive License Agreement, dated June 27, 2014, between the Trustees of Dartmouth College and Celdara Medical, LLC, as amended](http://www.sec.gov/Archives/edgar/data/1637890/000119312515191674/d893510dex1010.htm) | F-1 | 333-204251 | 10.10 | 5-18-2015 |
| 4.3\*\* | [Stock Purchase Agreement, by and among the registrant and Celdara Medical, LLC, dated as of January 5, 2015](http://www.sec.gov/Archives/edgar/data/1637890/000119312515206869/d893510dex1012.htm) | F-1/A | 333-204251 | 10.12 | 5-29-2015 |
| 4.4\*\* | [Asset Purchase Agreement, by and among OnCyte, LLC, Celdara Medical, LLC and the registrant, dated January 21, 2015](http://www.sec.gov/Archives/edgar/data/1637890/000119312515206869/d893510dex1013.htm) | F-1/A | 333-204251 | 10.13 | 5-29-2015 |
| 4.5 | [Agreement for the Provision of Services for Production of Cardiac Cells between Biological Manufacturing Services and the registrant, dated April 11, 2011 (English translation)](http://www.sec.gov/Archives/edgar/data/1637890/000119312515191674/d893510dex1015.htm) | F-1 | 333-204251 | 10.15 | 5-18-2015 |

---

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##### [**Table of Contents**](#toc)

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| 4.6† | [Warrant Plans (English translation)](http://www.sec.gov/Archives/edgar/data/1637890/000119312515191674/d893510dex1016.htm) | F-1 | 333-204251 | 10.16 | 5-18-2015 |
| 4.7† | [Warrant Plan 2016 (English translation)](http://www.sec.gov/Archives/edgar/data/1637890/000119312517109926/d365540dex419.htm) | 20-F | 001-37452 | 4.19 | 4-4-2017 |
| 4.8## | [First Amendment to Asset Purchase Agreement, dated as of August 3, 2017, by and among the registrant; Celdara Medical, LLC; and OnCyte, LLC](http://www.sec.gov/Archives/edgar/data/1637890/000119312517274350/d381273dex101.htm) | 6-K | 001-37452 | 10.1 | 8-31-2017 |
| 4.9 | [Subscription Agreement, dated as of August 3, 2017, by and between the registrant and Celdara Medical, LLC](http://www.sec.gov/Archives/edgar/data/1637890/000119312517274350/d381273dex102.htm) | 6-K | 001-37452 | 10.2 | 8-31-2017 |
| 4.10## | [Fourth Amendment to Exclusive License Agreement, dated as of August 2, 2017, by and between OnCyte, LLC and Trustees of Dartmouth College](http://www.sec.gov/Archives/edgar/data/1637890/000119312517274350/d381273dex103.htm) | 6-K | 001-37452 | 10.3 | 8-31-2017 |
| 4.11† | [Warrant Plan 2015 (English translation)](http://www.sec.gov/Archives/edgar/data/1637890/000119312517299545/d461912dex992.htm) | S-8 | 333-220737 | 99.2 | 9-29-2017 |
| 4.12† | [Warrant Plan 2017 (English translation)](http://www.sec.gov/Archives/edgar/data/1637890/000119312517299545/d461912dex993.htm) | S-8 | 333-220737 | 99.3 | 9-29-2017 |
| 4.13† | [Warrant Plan 2018 (English translation)](http://www.sec.gov/Archives/edgar/data/1637890/000119312519099411/d691824dex424.htm) | 20-F | 001-37452 | 4.24 | 4-5-2019 |
| 4.14† | [Warrants Plan 2019 (English translation)](http://www.sec.gov/Archives/edgar/data/1637890/000119312520084305/d861749dex425.htm) | 20-F | 001-37452 | 4.25 | 3-25-2020 |
| 4.15 | [Research and Development Collaboration and License Agreement, dated April 3, 2018, by and between the Company and Horizon Discovery Limited](http://www.sec.gov/Archives/edgar/data/1637890/000119312520084305/d861749dex428.htm) | 20-F | 001-37452 | 4.28 | 3-25-2020 |

---

------

##### [**Table of Contents**](#toc)

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| 4.16 | [Research and Development Collaboration and License Agreement, dated June 27, 2018, by and between the Company and Horizon Discovery Limited](http://www.sec.gov/Archives/edgar/data/1637890/000119312520084305/d861749dex429.htm) | 20-F | 001-37452 | 4.29 | 3-25-2020 |
| 4.17 | [First Amendment to Research and Development Collaboration and License Agreement, dated June 27, 2018, by and between the Company and Horizon Discovery Limited](http://www.sec.gov/Archives/edgar/data/1637890/000119312520084305/d861749dex430.htm) | 20-F | 001-37452 | 4.30 | 3-25-2020 |
| 4.18 | [Asset Purchase Agreement, dated November 22, 2019, by and between CorQuest Medical, Inc. and CorQuest MedTech](http://www.sec.gov/Archives/edgar/data/1637890/000119312520084305/d861749dex433.htm) | 20-F | 001-37452 | 4.33 | 3-25-2020 |
| 4.19 | [Clinical Trial Collaboration and Supply Agreement, dated September 14, 2020, by and between the Company and MSD International GmbH.](http://www.sec.gov/Archives/edgar/data/1637890/000119312521092779/d45316dex425.htm) | 20-F | 001-37452 | 4.25 | 3-24-2021 |
| 4.20† | [Warrants Plan 2020 (English Translation)](http://www.sec.gov/Archives/edgar/data/1637890/000119312521092779/d45316dex426.htm) | 20-F | 001-37452 | 4.26 | 3-24-2021 |
| 4.21## | [Subscription Agreement dated December 2, 2021, by and between CFIP CLYD LLC and the registrant](http://www.sec.gov/Archives/edgar/data/1637890/000119312521347354/d224773dex101.htm) | 6-K | 001-37452 | 10.1 | 12-3-2021 |

---

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##### [**Table of Contents**](#toc)

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| 4.22## | [Shareholders' Rights Agreement dated December 2, 2021, by and among CFIP CLYD LLC and the registrant](http://www.sec.gov/Archives/edgar/data/1637890/000119312521347354/d224773dex102.htm) | 6-K | 001-37452 | 10.2 | 12-3-2021 |
| 4.23## | [Fifth Amendment to Exclusive License Agreement, dated as of December 14, 2021, by and between Celyad Oncology SA and Trustees of Dartmouth College](http://www.sec.gov/Archives/edgar/data/1637890/000119312522083976/d303978dex431.htm) | 20-F | 001-37452 | 4.31 | 3-24-2022 |
| 4.24† | [Warrants Plan 2021 (English Translation)](http://www.sec.gov/Archives/edgar/data/1637890/000119312522083976/d303978dex432.htm) | 20-F | 001-37452 | 4.32 | 3-24-2022 |
| 4.25\*† | [Warrants Plan 2022 (English Translation)](d418841dex425.htm) |  |  |  |  |
| 8.1 | [List of subsidiaries of the registrant](http://www.sec.gov/Archives/edgar/data/1637890/000119312520084305/d861749dex81.htm) | 20-F | 001-37452 | 8.1 | 3-25-2020 |
| 12.1\* | [Certification by the Principal Executive Officer pursuant to Securities Exchange Act Rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002](d418841dex121.htm) |  |  |  |  |
| 12.2\* | [Certification by the Principal Financial Officer pursuant to Securities Exchange Act Rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002](d418841dex122.htm) |  |  |  |  |
| 13.1# | [Certification by the Principal Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002](d418841dex131.htm) |  |  |  |  |
| 13.2# | [Certification by the Principal Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002](d418841dex132.htm) |  |  |  |  |
| 15.1\* | [Consent of EY Réviseurs d'Entreprises / EY Bedrijfsrevisoren SRL/BV, independent registered public accounting firm](d418841dex151.htm) |  |  |  |  |
| 16.1\* | [Letter from EY Réviseurs d'Entreprises / EY Bedrijfsrevisoren SRL/BV to the SEC, dated March 23, 2023 regarding the change in independent registered public accounting firm](d418841dex161.htm) |  |  |  |  |

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##### [**Table of Contents**](#toc)

---

| | |
|:---|:---|
| 101 | The following financial information from the Registrant's Annual Report on Form 20-F for the year ended December 31, 2022, formatted in XBRL (eXtensible Business Reporting Language): (i) Consolidated Statements of Financial Position; (ii) Consolidated Statements of Profit or Loss; (iii) Consolidated Statements of Changes in Equity; (iv) Consolidated Statements of Cash Flows; and (v) Notes to Consolidated Financial Statements, tagged as blocks of text and in detail. |
| 104 | Cover Page Interactive Data File (embedded within the Inline XBRL document) |

---

\* Filed herewith

# Furnished herewith

† Indicates a management contract or compensatory plan, contract or arrangement

\*\* Certain exhibits and schedules to these agreements have been omitted pursuant to Item 601(b)(2) of Regulation S-K. The registrant will furnish copies of any of the exhibits and schedules to the Securities and Exchange Commission upon request.

## Certain portions of this exhibit have been omitted because they are not material and the registrant customarily and actually treats that information as private or confidential.

------

##### [**Table of Contents**](#toc)

#### SIGNATURES
The registrant hereby certifies that it meets all of the requirements for filing on Form 20-F and that it has duly caused and authorized the undersigned to sign this annual report on its behalf.

---

| |
|:---|
| **Celyad Oncology SA** |
| /s/ Michel Lussier  |
| By: Michel Lussier |
| Title: Interim Chief Executive Officer *(Principal Executive Officer)* |
| /s/ David Georges |
| By: David Georges |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Title: Vice President of Finance and Administration (*Principal*<br> *Financial Officer*) |

---

Date: March 23, 2023

## Exhibit 1.1

**Exhibit 1.1**![LOGO](g418841g0314201111394.jpg)

SCRL civile Berquin Notaires – avenue Lloyd George 11 – 1000 Bruxelles

VAT BE 0474.073.840 – BRUSSELS Registry of Legal Entities – www.berquinnotaires.be

Tel.: +32(2)645.19.45 Fax: +32(2)645.19.46

Coordinated Articles of Association

of the listed société anonyme (a Belgian corporation)

**"Celyad Oncology"** 

at 1435 Mont-Saint-Guibert, Rue Edouard Belin 2,

company number 0891.118.115 - Brabant Wallon Registry of Legal Entities

following amendment of the articles of

association on December 8, 2021

------

**<u>HISTORY</u>** 

<u>ARTICLES OF ASSOCIATION</u>

The Company was formed with the name "Cardio³ BioSciences" following a document received by Counselor Gérard Indekeu, a notary in Brussels, on July 24, 2007, published in the Appendices to the Moniteur Belge (the Belgian official gazette) on the following August 6, under number 07117087.

<u>AMENDMENTS TO THE ARTICLES OF ASSOCIATION</u>

The articles of association were modified following a memorandum drawn up by the aforementioned notary Indekeu on August 31, 2007, published in the appendices to the Moniteur Belge under number 20071003/0143533.

The articles of association were modified following a memorandum drawn up by the notary and partnership, Pierre Paulus de Châtelet, having resided in Rixensart, on September 26, 2008, Moniteur Belge number 2008-10-13 / 0162065.

The articles of association were modified following a memorandum drawn up by the aforementioned notary Pierre Palus de Châtelet, on December 23, 2008, published in the appendices to the Moniteur Belge under number 20090120/09010290.

The articles of association were modified following a memorandum drawn up by the aforementioned notary Pierre Palus de Châtelet, on May 5, 2010, published in the appendices to the Moniteur Belge under number 2010-06-03 / 0079698.

The articles of association were modified following a memorandum drawn up by the aforementioned notary Pierre Palus de Châtelet, on October 29, 2010, published in the appendices to the Moniteur Belge under number 20101201-0174259.

The articles of association were corrected following a memorandum drawn up by the notary Françoise Montfort in Rixensart, on January 7, 2011, published in the appendices to the Moniteur Belge under number 20110131-0016668.

The articles of association were modified following a memorandum drawn up by the aforementioned notary Françoise Montfort, on May 5, 2011, published in the appendices to the Moniteur Belge under number 20110606-84155.

The articles of association were modified following a memorandum drawn up by the aforementioned notary Françoise Montfort, on May 6, 2013, published in the appendices to the Moniteur Belge under number 2013-06-05 / 0084810.

The articles of association were modified following a memorandum drawn up by the aforementioned notary Françoise Montfort, on May 31, 2013, published in the appendices to the Moniteur Belge under number 2013-06-20 / 0093935.

The articles of association were modified following a memorandum drawn up by the aforementioned notary Françoise Montfort, on June 4, 2013, published in the appendices to the Moniteur Belge under number 2013-06-24 / 0095581.

The articles of association were modified following a memorandum drawn up by the aforementioned notary Françoise Montfort, on July 9, 2013, published in the appendices to the Moniteur Belge under number 2013-07-26 / 0117431.

The articles of association were modified following a memorandum drawn up by the aforementioned notary Françoise Montfort, on July 17, 2013, published in the appendices to the Moniteur Belge under number 2013-08-16/0128300.

The articles of association were modified following a memorandum drawn up by the aforementioned notary Françoise Montfort, on September 26, 2013, published in the appendices to the Moniteur Belge under number 2013-10-14-0155339.

The articles of association were modified following a memorandum drawn up by the aforementioned notary Françoise Montfort, on January 31, 2014, published in the appendices to the Moniteur Belge under number 20140319-0063903.

The articles of association were modified following a memorandum drawn up by the aforementioned notary Françoise Montfort, on May 5, 2014, published in the appendices to the Moniteur Belge under number 2014-06-05 / 0112591.

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The articles of association were modified following a memorandum drawn up by the aforementioned notary Françoise Montfort, on June 16, 2014, published in the appendices to the Moniteur Belge under number 20140709/0132868.

The articles of association were modified following a memorandum drawn up by the aforementioned notary Françoise Montfort, on June 30, 2014, published in the appendices to the Moniteur Belge under number 20140722/0141424.

The articles of association were modified following a memorandum drawn up by the aforementioned notary Françoise Montfort, on August 4, 2014, published in the appendices to the Moniteur Belge under number 20140825-0159432.

The articles of association were modified following a memorandum drawn up by the aforementioned notary Françoise Montfort, on November 3, 2014, published as an excerpt in the appendices to the following Moniteur Belge under number 20141128-0214987.

The articles of association were modified following a memorandum drawn up by the aforementioned notary Françoise Montfort, on January 31, 2014, published in the appendices to the Moniteur Belge under number 2015-02-13 / 0024685.

The articles of association were modified following a memorandum drawn up by the aforementioned notary Françoise Montfort, on February 7, 2015, published in the appendices to the Moniteur Belge under number 2015-02-26 / 0031768

The articles of association were modified following a memorandum drawn up by the aforementioned notary Françoise Montfort, on March 3, 2015, published in the appendices to the Moniteur Belge under number 20150325-0044740.

The articles of association were modified with a company name change to "Celyad" following a memorandum drawn up by the aforementioned notary Françoise Montfort, on May 5, 2015, currently in the process of publication.

The articles of association were modified following a memorandum drawn up by the aforementioned notary Françoise Montfort, on May 11, 2015, published as an excerpt in the appendices to the following Moniteur Belge under number 20150602-077515.

The articles of association were modified following a memorandum drawn up by the aforementioned notary Françoise Montfort, on June 24, 2015, published as an excerpt in the appendices to the Moniteur Belge under number 20150715-0102184.

The articles of association were modified following a memorandum drawn up by the aforementioned notary Françoise Montfort, on August 4, 2015, published in the appendices to the Moniteur Belge on the following September 4 under number 15126625.

The articles of association were modified following a memorandum drawn up by Counselor Peter Van Melkebeke, a notary in Brussels, on February 1, 2017, published in the appendices to the Moniteur Belge on the following February 21 under number 17028104.

The articles of association were modified following a memorandum drawn up by Counselor Peter Van Melkebeke, a notary in Brussels, on May 2, 2017, published in the appendices to the Moniteur Belge on the following May 22 under number 17072065.

The articles of association were modified following a memorandum drawn up by Counselor Gaëtan Delvaux, a notary in Jodoigne, standing in for his colleague, Counselor Peter Van Melkebeke, a notary in partnership in Brussels, suffering a statutory impediment *ratione loci*, on June 29, 2017, published in the appendices to the Moniteur Belge on the following August 2, under number 17112698.

The articles of association were modified following a memorandum drawn up by Counselor Peter Van Melkebeke, a notary in Brussels, on August 1, 2017, published in the appendices to the Moniteur Belge on the following August 25 under number 1712334.

The articles of association were modified following a memorandum drawn up by Counselor Peter Van Melkebeke, a notary in Brussels, on August 23, 2017, published in the appendices to the Moniteur Belge on the following September 7 under number 17128258.

The articles of association were modified following a deed drawn up before Counselor Tim Carnewal, a notary in Brussels, on November 9, 2017, published in the appendices to the Moniteur Belge on the following December 4, under number 17169624.

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The articles of association were modified following a deed drawn up by Counselor Tim Carnewal, a notary in Brussels, on February 7, 2018, published in the appendices to the Moniteur Belge on the following February 28, under number 18038617.

The articles of association were modified following a deed drawn up before counselor Peter Van Melkebeke, a notary in Brussels, on May 22, 2018, published in the appendices to the Moniteur Belge on the following May 22, under number 18315097.

The articles of association were modified following a deed drawn up before Counselor Peter Van Melkebeke, a notary in Brussels, on May 23, 2019, published in the appendices to the Moniteur Belge on the following June 6, under number 19320254.

The articles of association were modified following a deed drawn up before Counselor Peter Van Melkebeke, a notary in Brussels, on September 16, 2019, published in the appendices to the Moniteur Belge on the following October 2, under number 19336608.

The articles of association were modified following a deed drawn up before Counselor Peter Van Melkebeke, a notary in Brussels, on June 8, 2020, published in the appendices to the Moniteur belge on the following June 22, 2020, under number 20069480.

The articles of association were modified following a deed drawn up before Counselor Peter Van Melkebeke, a notary in Brussels, on January 8, 2021, published in the appendices to the Moniteur belge on the following January 20, 2021, under number 21304690.

The articles of association were modified following a deed drawn up before Counselor Peter Van Melkebeke, a notary in Brussels, on March 29, 2021, published in the appendices to the Moniteur belge on the following April 2, 2021, under number 21321039.

The articles of association were modified following a deed drawn up before Counselor Peter Van Melkebeke, a notary in Brussels, on April 9, 2021, published in the appendices to the Moniteur belge on the following April 15, 2021, under number 21324088.

The articles of association were modified following a deed drawn up before Counselor Peter Van Melkebeke, a notary in Brussels, on April 29, 2021, published in the appendices to the Moniteur belge on the following May 7, 2021, under number 21329013.

The articles of association were modified following a deed drawn up before Counselor Peter Van Melkebeke, a notary in Brussels, on May 21, 2021, published in the appendices to the Moniteur belge on the following May 31, 2021, under number 21333097.

The articles of association were modified following a deed drawn up before Counselor Jean-Frédéric VIGNERON, notary in Wavre, replacing Peter Van Melkebeke, notary in Brussels, prevented ratione loci, on May 25, 2021, published in the appendices to the Moniteur belge on the following June 9, 2021, under number 21335214.

The articles of association were modified following a deed drawn up before Counselor Peter Van Melkebeke, a notary in Brussels, on June 14, 2021, published in the appendices to the Moniteur belge on the following June 9, 2021, under number 21339039.

The articles of association were modified following a deed drawn up before Counselor Peter Van Melkebeke, a notary in Brussels, on June 28, 2021, published in the appendices to the Moniteur belge on August 23, 2021, under number 21349967.

The articles of association were modified following a deed drawn up before Counselor Peter Van Melkebeke, a notary in Brussels, on July 22, 2021, published in the appendices to the Moniteur belge on September 3, 2021, under number 21351913.

The articles of association were modified following a deed drawn up before Counselor Peter Van Melkebeke, a notary in Brussels, on October 20, 2021, published in the appendices to the Moniteur belge on September 3, 2021, under number 21367545.

The articles of association were modified following a deed drawn up before Counselor Peter Van Melkebeke, a notary in Brussels, on December 8, 2021, sent for publication to the Moniteur belge.

<u>CHANGE IN REGISTERED OFFICE</u>:

The registered office was changed to the current address by decision of the board of directors dated March 16, 2016, published in the appendices to the Moniteur Belge of the following June 9, under number 16079203.

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**ARTICLES OF ASSOCIATION** 

**COORDINATED AS OF DECEMBER 8, 2021** 

**<u>ARTICLE 1 – FORM AND NAME</u>** 

The company has the form of a listed société anonyme (a Belgian corporation).

It is named: "Celyad Oncology". This name shall always be preceded or followed by the words "société anonyme" or by the abbreviation "SA".

**<u>ARTICLE 2 – REGISTERED OFFICE- WEBSITE</u>** 

The registered office is located in the Walloon region.

The board of directors may transfer the registered office to any other location in Belgium, provided that such relocation does not require a change in the language of the Articles of Association pursuant to the applicable language regulations and has the authority to amend the Articles of Association. If the language of the Articles of Association must be changed because of the relocation of the registered office, it is only the general meeting that has the ability to take this decision, in compliance with the rules for the amendment of the Articles of Association. Any transfer in registered office shall be published in the appendices to the Moniteur Belge.

The board of directors is, furthermore, authorized to establish administrative offices, operations offices, branches and agencies, both in Belgium and abroad.

The website of the company is: www.celyad.com.

The board of directors is authorized to modify the website address.

**<u>ARTICLE 3—PURPOSE</u>** 

The purpose of the company, both in Belgium and abroad, in its own name or in the name of third parties, on its own behalf or on behalf of third parties, is the development of new medical technologies and particularly, but not exclusively, the research and development, manufacture and sale of elements and systems, including in this procedures, formulae, methods for development and manufacture, instruments and equipment, materials and products, prototypes, software and technical and research programs, designs, patents, and marks, all of which are directly or indirectly related to biotechnology and particularly, but not exclusively, cellular therapies and the various scientific, operational, legal, and financial matters directly or indirectly related thereto. The company may, if necessary, file, record all or part of its research (patents, inventions, marks) and proceed with any other operation directly or indirectly related to its corporate purpose if such operations prove necessary in the pursuit of its activities.

The company may perform, both in Belgium and abroad, any and all industrial, commercial, and financial operations, and those operations involving real and movable property which may expand or promote the company directly or indirectly.

It may acquire any and all real or movable assets, even if they have no direct or indirect connection with the company's purpose.

It may grant any form of collateral as a guarantee of commitments of a related company, a partner, with whom a connection of participation exists, or with any third party in general.

It may, by any means whatsoever, acquire an interest in, cooperate, or merge with any and all associations, businesses, enterprises, or companies which have an identical, similar, or related corporate purpose or which are capable of promoting its enterprise or facilitating the sale of its products or services. It may acquire an interest, by means of contribution, assignment, merger, subscription, participation, financial intervention or otherwise, in any and all companies, enterprises, or operations having a similar or related purpose, or which are of a nature to promote the realization of its purpose.

**<u>ARTICLE 4 – TERM</u>** 

The company is formed for an unlimited term.

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**<u>ARTICLE 5 – SHARE CAPITAL</u>** 

The company's share capital is set at seventy eight million five hundred eighty four thousand two hundred twenty four euros and thirty three eurocents (78.584.224,33 EUR), represented by twenty two million five hundred ninety three thousand nine hundred fifty six (22.593.956) shares which do not contain a face value, each representing an equal share of the capital.

**<u>ARTICLE 6 – CHANGES TO THE SHARE CAPITAL</u>** 

The share capital may be increased or reduced by a decision of the general meeting deliberating as provided by the provisions established for modifying the articles of association.

Whenever there is an increase in share capital, the new shares to be subscribed in cash must be offered by preference to the shareholders in proportion to the part of the share capital represented by their shares for a period of at least 15 days starting from the first day of the subscription period. The general meeting determines the subscription price and the period during which the preferential right may be exercised. However, this preferential subscription right may be limited or eliminated by the general meeting ruling in the interest of the company and by modifying the articles of association. Where capital is raised with the creation of an issue premium, the amount of this premium must be fully paid-up upon subscription. The premium must be booked to an escrow account labeled "Issue premiums" which may only be reduced or eliminated by a decision of the general meeting deliberating pursuant to the provisions provided by the Code of Companies and Associations for modifying the articles of association. The issue premium shall, just like the share capital, be considered a common surety benefiting third parties.

**<u>ARTICLE 7 – AUTHORIZED CAPITAL</u>** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.1 The board of directors is authorized to increase the share capital on one or more occasions, up to the amount of forty-eight million five hundred twelve thousand six hundred and fourteen euros and fifty-seven eurocents (€48,512,614.57)on the dates and pursuant to the procedures to be established by the board of directors, this being for a term of five years starting from the publication of the extraordinary general meeting held on June 8, 2020 in the appendices of the Moniteur Belge.

This authorization is renewable in such conditions as provided by law.

The board is authorized to increase the share capital as described above, both through cash contributions or, subject to legal limits and conditions, through in-kind contributions, and by incorporation of available or unavailable reserves or from the "issue premium" account. In the latter cases, the increase may occur with or without the issuance of new shares.

An increase in capital as regards authorized capital, may also occur through the issuance of convertible bonds or subscription rights – which may or may not be attached to another security – that may result in the creation of shares pursuant to applicable legal provisions.

The board of directors is authorized, when raising capital, issuing convertible bonds or subscription rights, to limit or eliminate, in the company's interest, the preferential right provided by current legal provisions, including those benefiting one or more given persons, whether or not they are members of the company's staff or of its subsidiaries.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.2 When an increase in capital approved by the board of directors includes an issue premium, the amount thereof is, after deducting any costs, posted to an escrow account which shall constitute, with regard to the capital, surety for third parties and may only be reduced or eliminated by a decision of the general meeting ruling as a quorum and by a majority required for reducing capital, without prejudice to the board of directors' right to incorporate said account into the capital as provided above in 7.1.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.3 Pursuant to a decision by the extraordinary general meeting of the shareholders held on June 8, 2020, the board of directors may also use the authorizations set forth above, following receipt by the company of a communication from the Financial Markets and Services Authority, within three years starting from the day of the aforementioned extraordinary general meeting, whereby the company is served notice of a public takeover bid targeting the company, through cash contributions by limiting or eliminating the shareholders' preferential right (including when benefiting one or more given persons who are not employees of the company or of its subsidiaries) or through in-kind contributions, with the issuance of shares, warrants, or convertible bonds, pursuant to the applicable legal provisions.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.4 The board of directors is authorized, with the power of substitution, to amend the articles of association whenever there is an increase in capital realized as part of the authorized capital, so as to adapt to the new situation with respect to the share capital and shares.

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**<u>ARTICLE 8 – ACQUISITION, ACCEPTANCE AS COLLATERAL, AND DISPOSAL OF TREASURY SHARES</u>** 

The company may acquire or accept as collateral its own shares in such conditions as provided by law. The board of directors is authorized to dispose of the company's shares through a stock market or outside of a stock market, when the shares have been acquired by the company, at conditions set by the board, without prior authorization from the general meeting, as provided by law.

The above-referenced authorizations extend to acquisitions and disposals of the company's shares made by its subsidiaries, as these subsidiaries are defined by the legal provisions pertaining to the acquisitions of shares of the parent company by subsidiaries, and are extendible in such conditions as provided by law.

**<u>ARTICLE 9 – CALL FOR FUNDS</u>** 

The board of directors shall have sole authority to decide on the date and manner whereby calls for funds shall be made regarding shares that have not been fully paid-up.

If a shareholder has not made the called-for payments on his shares within the deadline set by the board of directors, the exercise of the voting rights associated with said shares shall be suspended automatically as long as such payments shall not have been made. Furthermore, the shareholder shall owe the company, as of right, a penalty interest equal to the legal interest rate augmented by two percent.

If the shareholder continues to default following notice sent by registered mail following the expiration of the deadline set by the board of directors, the latter may cause the shares in question to be sold on the stock market, by using an investment company or a lending institution, without prejudice to the company's right to demand that he pay the balance due, as well as any and all damages and interest.

A shareholder may not pay up his shares in advance without prior approval from the board of directors.

**<u>ARTICLE 10 – TYPE OF SHARES AND REGISTERED SHARE LEDGER</u>** 

Shares are registered or dematerialized shares.

The registered share ledger is maintained electronically. The board of directors may decide to entrust the keeping and administration of the electronic ledger to a third party. All entries in this ledger, including transfers and conversions, can be made validly on the basis of documents or instructions which the securities assignor, assignee, or owner may send electronically or by any other means. The company may accept and record in this ledger any transfer that might be recorded through correspondence or other documents establishing the agreement between the assignor and assignee.

**<u>ARTICLE 11 – EXERCISE OF RIGHTS ASSOCIATED WITH SECURITIES</u>** 

With regard to the company, the shares and the other securities issued by the company are indivisible. If one of these securities belongs to multiple people or if the rights associated with one of these securities are divided between multiple people, the rights associated there with shall be suspended as of right until only one person has been designated as owner of the security with regard to the company. The rights associated with shares that are subject to usufruct or a pledge or exercise respectively by the beneficial owner and by the title owner making the pledge, unless there is an agreement otherwise, signed by all interested parties, submitted to the company.

**<u>ARTICLE 12 – COMPOSITION OF THE BOARD OF DIRECTORS</u>** 

The company is administered by a collegial administrative body, called the board of directors, validly composed of at least three members, who may or may not be shareholders, individuals or legal entities.

If a legal entity is designated as a director of the company, it must designate, pursuant to the rules established by the Code of Companies and Associations, a permanent representative, authorized to represent it in all of its relations with the company. The director may only revoke its permanent representative by simultaneously appointing his successor.

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At least one third of the members of the board of directors shall be of a different gender than the other members; the minimum number required shall be rounded to the nearest whole number. If the director is a legal entity, its gender is determined by that of its permanent representative.

If for any reason whatsoever, the composition of the board of directors does not meet or no longer meets the conditions set out in the previous paragraph, the first subsequent general meeting shall constitute a board of directors which meets these requirements, without prejudice to the regularity of the composition of the board of directors until that date. Any other appointment is null and void.

The term of a director may not exceed six years. Directors whose term of office has ended shall remain in office so long as the general meeting, for any reason whatsoever, does not proceed with their replacement.

Outgoing directors may be reelected.

Directors may, at any time, be removed by the general meeting.

**<u>ARTICLE 13 – VACANCY PRIOR TO EXPIRATION</u>** 

Should there be a vacancy on the board of directors, the remaining directors are entitled to co-opt a new director.

The first subsequent general meeting shall confirm the co-opted director's term of office; in the event of confirmation, the co-opted director shall terminate the term of office of his predecessor, unless the general meeting decides otherwise. In the absence of confirmation, the term of office of the co-opted director shall end after the general meeting, without affecting the regularity of the composition of the board of directors until that date.

If the composition of the board of directors no longer meets the conditions set out in article 12, subsections 8 and 9 of the Articles of Association, due to the vacancy of a director's position, the board of directors exercising its power of co-option shall ensure that its composition meets the conditions again, without this being prejudicial to the regularity of the composition of the board of directors until then. Any other appointment is null and void.

**<u>ARTICLE 14 – CHAIRMANSHIP</u>** 

The board of directors shall elect, from amongst its members, a chairman by simple majority. In the event in which the vote should be tied, the chairman shall cast the deciding vote.

**<u>ARTICLE 15 – MEETINGS OF THE BOARD OF DIRECTORS</u>** 

The board shall be summoned for meeting by its chairman (or by any person to whom the chairman has delegated such power) or by two directors whenever the interest of the company so demands. A notice of meeting shall be made to validly in writing, by fax, by email, or by telephone.

The notice of meeting shall state the place, date, time, and agenda for the meeting. It shall be sent at least two business days prior to the meeting by letter, fax, email, or any other written means. Where there is a justifiable emergency, this period may be less than two business days. Should there be no chairman or in the event of his impediment, a director designated for this purpose by his colleagues shall preside over the meeting.

If all directors are present or validly represented, the validity of the notice of meeting cannot be contested. Except if and unless the board of directors decides otherwise, any person tasked with the daily management of the company may attend and participate in the meetings of the board of directors, however, without a right to vote; so as to avoid any misunderstanding, it is stipulated that the above applies only in the case where the CEO is not a member of the board of directors.

**<u>ARTICLE 16 – DELIBERATIONS</u>** 

At least a majority of the directors must be present (physically or by telephone or by video conference) or represented to form a quorum. In the case in which a majority of directors is not present at a meeting of the board of directors, each director shall have the right to give notice of meeting for a second meeting of the board of directors with the same agenda, which shall be held within a reasonable time frame (which shall not be less than 15 days, unless the urgency of the decisions to be made requires proceeding otherwise, with a minimum of three days) starting from the written communications sent to all directors referencing this article. Without prejudice to the fifth paragraph of this article, this second meeting of the board of directors shall have the right to debate and make decisions based on the agenda, regardless of the number of directors present or represented.

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The board of directors may validly debate points that are not mentioned on the agenda only if all of the directors are personally present and unanimously decide to debate these points.

Any director may give a power of attorney to one of his colleagues by letter, fax, email, or any other written means, to represent him at a meeting of the board of directors. A director may represent as many colleagues as needed.

Except as stated in the following paragraph, decisions by the board of directors are made according to a majority of votes placed. Blank or irregular ballots cannot be added to votes placed. If there is a tie in the vote, the vote by director presiding over the meeting shall be decisive, unless the board of directors is composed of two members.

If a director has, directly or indirectly, an interest related to his holdings that is in opposition to a decision or an operation within the purview of the board of directors, the rules and formalities provided by the Code of Companies and Associations must be respected.

If there is an emergency, decisions by the board of directors may be made, insofar as the law so authorizes, by unanimous consent of the directors expressed in writing. However, this procedure may not be used to approve the annual financial statements and the use of authorized capital.

Unless stipulated otherwise, decisions made by unanimous consent expressed in writing are deemed to be made at the registered office and take effect as of the date of the last signature by a director. Directors may participate at a meeting of the board of directors by teleconference, video conference, or by any other means of communication that allows all directors to communicate between themselves.

They shall then be deemed to have been present at this meeting.

Unless stipulated otherwise, decisions shall be deemed to have been made at the registered office and to take effect as of the meeting date.

**<u>ARTICLE 17 – MINUTES</u>** 

The debates by the board of directors shall be recorded in minutes signed by the directors present or their representatives. The powers of attorney are attached to the minutes.

Copies or excerpts, to be produced in a court of law or elsewhere, shall be signed by at least two directors or by a managing director.

**<u>ARTICLE 18 – POWERS OF THE BOARD OF DIRECTORS</u>** 

The board of directors is vested with the broadest powers for the purpose of performing all acts useful or necessary for the realization of the corporate purpose.

It has the power to perform all acts that are not expressly reserved by law or by the articles of association to the general meeting.

The board of directors may, within the scope of its powers, delegate to a third party of its choosing, a portion of its powers for special and determined purposes. The board of directors shall create an audit committee pursuant to the Code of Companies and Associations from within its ranks. The audit committee is tasked with providing permanent oversight of the tasks performed by the statutory auditor and performing any additional mission that might be entrusted to it by the board of directors. Should the formation of an audit committee from within the board of directors not be mandatory, the board of directors may decide that the duties attributed to the audit committee must then be performed by the board of directors as a whole.

The board of directors may create other committees, the powers of which it shall establish.

**<u>ARTICLE 19 – COMPENSATION</u>** 

Directorships are performed free of charge, except as decided otherwise by the general meeting.

The company may be exempt from the provisions of article 7:91, subsections 1 and 2 of the Code of Companies and Associations as regards any person falling within the scope of application of these provisions.

**<u>ARTICLE 20 – REPRESENTATION</u>** 

The company shall be validly represented in all of its acts, including representation in a court of law, by two directors acting jointly or by a managing director, acting alone, and shall not be required to justify a prior decision by the board of directors with regard to third parties.

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The company, furthermore, shall be validly represented by an agent within the limits of that person's mandate.

**<u>ARTICLE 21 – DAY-TO-DAY MANAGEMENT</u>** 

The board of directors may delegate the company's day-to-day management to one or more persons, whether individuals or legal entities. If the person tasked with the day-to-day management is also a director, that person shall bear the title of managing director (or Chief Executive Officer, or CEO). Otherwise, the person shall bear the title of general manager.

The mandate as agent for day-to-day management shall be performed free of charge, except as decided otherwise by the board of directors.

It alone is competent to determine the conditions and limits of such delegation and to terminate it.

When multiple people are tasked with the day to day management, the company shall be validly represented in all of its acts of day-to-day management, including representation before a court of law, by one person tasked with the day-to-day management, who shall not be required to justify a prior decision of the board of directors with regard to third parties.

Any person tasked with the day-to-day management may, within the scope of his powers, delegate to a third party of his choosing, a portion of his powers for special and determined purposes.

**<u>ARTICLE 22 – AUDIT</u>** 

The audit of the company shall be entrusted to one or more auditors, appointed for a renewable three-year term.

Auditors are appointed from amongst the company auditors, registered with the Public Registry of the Company Auditors or from amongst registered auditor offices.

The general meeting shall determine the number of auditors and establish their compensation.

**<u>ARTICLE 23 – AUDITORS TASKS</u>** 

The auditors, collectively or individually, have an unlimited right to oversee and audit the financial condition, the annual financial statements, and the accuracy, in light of the prevailing legal provisions and the articles of association, of the operations to be recorded in the annual financial statements.

They may, without moving from the site, inspect the books, correspondence, reports, and generally all writings of the company.

Each semester, the board of directors shall provide them with a statement summarizing the company's assets and liabilities

The auditors shall write, for purposes of the general meeting, a detailed report specifically containing the information provided by law. The auditors may, in the performance of their duties and at their cost, be assisted by agents or other persons for whom they are responsible.

**<u>ARTICLE 24 – COMPOSITION AND POWERS OF THE GENERAL MEETING</u>** 

The duly constituted general meeting represents all shareholders. Decisions made by the general meeting are binding on all shareholders, even those who are dissident or absent. It has the broadest powers to perform or ratify acts involving the company.

**<u>ARTICLE 25 – MEETINGS</u>** 

The ordinary general meeting automatically shall be held on the fifth of May at nine in the morning. If this day falls on a Saturday, a Sunday, or a legal holiday, the general meeting shall be held on the following business day.

An extraordinary general meeting may be convened whenever the company's interest so requires and must be convened whenever shareholders representing one fifth of the share capital so request.

General meetings are held at the registered office or at any other location indicated in the meeting notices.

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**<u>ARTICLE 26 – NOTICE OF MEETING</u>** 

The general meeting shall meet following a notice of meeting sent by the board of directors or the auditors.

These meeting notices shall particularly contain the place, date, time and agenda for the general meeting, containing information about the subjects to be discussed as well as proposed decisions, and shall be made in the forms and within the deadlines prescribed by the Code of Companies and Associations.

Each year, at least one ordinary general meeting shall be held, for which the agenda shall state at least: (i) as applicable, the discussion of the management report and the auditors' report, (ii) the discussion and approval of the annual financial statements and the allocation of any earnings, (iii) the release to be granted to the directors and, (iv) as applicable, to the commissioners, and, as applicable, (v) the appointment of directors and auditors.

**<u>ARTICLE 27 – ADMISSION</u>** 

The right to participate in a general meeting and to exercise the voting right and it is subordinate to the recognition on the books of the shares in the shareholder's name on the fourteenth day that precedes the general meeting, at eight PM (Belgian time), or by their registration in the ledger of registered shares for the company, or by their registration in the books of an approved account holder or of a liquidation body, without a need to enumerate the number of shares held by the shareholder as of the day of the general meeting.

The shareholder shall inform the company, or the person it has designated for this purpose, of his desire to participate in the general meeting, no later than the sixth day preceding the meeting date.

Holders of dematerialized securities must make their intention to exercise their rights at the meeting known to one of the financial institutions shown in the notice of meeting or to any other institution specified in the notice of meeting, and must do so in accordance with the procedures stated in the notice of meeting no later than the sixth day preceding the meeting date. Holders of bonds, subscription rights, or warrants issued with the company's collaboration may attend the general meeting, but only with a consultative vote and provided that they comply with the conditions for admission provided for shareholders.

**<u>ARTICLE 28 – REPRESENTATION</u>** 

Any shareholder may give a power of attorney to 1/3 party of his choosing by letter, fax, email, or any other written means, so that he may be represented at a general meeting.

The board of directors may establish the form of powers of attorney in the meeting notices. The powers of attorney must reach the company no later than the sixth day preceding the date of the general meeting.

**<u>ARTICLE 29 – OFFICE</u>** 

Each general meeting shall be presided over by the chairman of the board of directors or failing that or in the event of that person's impediment, by a person designated for this purpose by the general meeting.

The meeting chairman may appoint a secretary, who does not necessarily need to be a shareholder or director.

If the number of shareholders present or represented so allows, the general meeting may select two vote counters. The directors present complete the executive committee.

**<u>ARTICLE 30 – POSTPONEMENT</u>** 

The board of directors has the right to postpone, during a meeting, any general meeting whether ordinary or otherwise by five weeks.

This postponement shall not nullify the other decisions taken, unless the general meeting decides otherwise.

The formalities fulfilled to attend the first meeting, including any submissions of powers of attorney, shall remain valid for the second meeting.

The postponement may only occur once. The second general meeting shall be entitled to definitively establish the annual financial statements.

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**<u>ARTICLE 31 – NUMBER OF VOTES – EXERCISE OF THE RIGHT TO VOTE</u>** 

Without prejudice to the following paragraphs, each share gives the right to one vote.

All fully paid-up shares, which have been registered for at least two years without interruption in the name of the same shareholder in the register of registered shares, have double voting rights compared to other shares representing the same share capital.

The two-year period begins on the date on which the shares are registered, even though this registration was made before the date of adoption of the Article of Association provision establishing double voting rights and before the company is listed.

In the event of a capital increase by capitalization of reserves, the double voting right is recognized as from their issuance to the bonus shares allocated to shareholders on the basis of the existing shares for which they hold this right.

Any share converted into dematerialized share or transferred in ownership loses the double voting right granted pursuant to subsection 2 of this article.

However, the transfer of shares following inheritance, liquidation of matrimonial property rights or transfer, either for payment or free of charge to an heir, shall not entail the loss of double voting rights and shall not interrupt the period referred to in subsection 3 of this article.

The same shall apply in the case of the transfer of shares between companies which are controlled by the same, or if there is joint control, by the same controlling shareholders, either natural or legal persons, or between one of these companies and these controlling shareholders. If the shares are held by a company, the change of control of the company is equivalent to a transfer of those shares, unless the change of control is for the benefit of the spouse or one or more successors of the shareholder or shareholders controlling that company.

Nor shall the transfer of shares to a legal person against the issue of certificates referred to in Article 7:61, §1 of the Code of Companies and Associations, together with the commitment of this person to reserve any product or income for the holder of these certificates, nor the exchange of certificates for shares referred to in Article 7:61, §1, subsection 6 or §2, subsection 2 of the said Code result in the loss of the double voting right referred to in subsection 2 of this article or shall it interrupt the period referred to above, provided that it is for the benefit of the person who carried out the certification or one of its transferees meeting the legal conditions.

The merger or demerger of the company has no effect on the double voting right which may continue to be exercised within the beneficiary companies, if the latter's Articles of Association so provide.

**<u>ARTICLE 32 – DELIBERATIONS</u>** 

Before entering into session, an attendance list showing the name of the shareholders and the number of shares they hold shall be signed by each of them or by their agent. The same applies for bearers of other securities issued by the company or in collaboration with it.

The general meeting may not deliberate points not shown on the agenda, except if all of the shareholders are present or represented at the general meeting and unanimously decide to deliberate these points.

Directors shall respond to questions put to them by the shareholders with regard to the points contained on the agenda. As applicable, the auditors shall respond to questions put to them by the shareholders with regard to their report.

Except as provided otherwise by law or in the articles of association, any decision made by the general meeting shall be made by a simple majority of votes, regardless of the number of shareholders present or represented. Blank or irregular ballots cannot be added to votes placed.

If, during a decision on an appointment, and none of the candidates obtains an absolute majority of votes, a new vote shall be conducted as between the two candidates who received the greatest number of votes. Should there be a tie in votes on the occasion of this new vote, the older candidate shall be elected.

Votes are cast by a raising of hands or calling by name unless the general meeting decides otherwise by simple majority of votes cast.

The shareholders may, unanimously, make in writing any and all decisions falling within the competence of the general meeting, except for those which must be made in an authenticated document. Unless stipulated otherwise, decisions made in writing are deemed to be made at the registered office and take effect as of the date of the last signature by a shareholder.

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**<u>ARTICLE 33 – MINUTES</u>** 

The minutes of the general meeting shall be signed by the members of the executive committee and by the shareholders who so request.

Except as otherwise provided by law, copies or excerpts, to be produced in a court of law or elsewhere, shall be signed by two directors (or by one managing director).

**<u>ARTICLE 34 – ANNUAL FINANCIAL STATEMENTS</u>** 

Each fiscal year begins on January first and ends on December thirty-first of each year.

At the end of each fiscal year, the board of directors shall oversee the creation of an inventory as well as the annual financial statements. Insofar as is required by law, the board of directors shall further write a report in which it shall report on its management. This report shall contain a commentary about the annual financial statements for the purpose of presenting faithfully the evolution in business and the company's condition, as well as the other elements required by the Code of Companies and Associations.

**<u>ARTICLE 35 – APPROVAL OF THE ANNUAL FINANCIAL STATEMENTS</u>** 

The ordinary general meeting shall hear, as applicable, the management report and the auditors' report and shall vote on approval of the annual financial statements.

Following approval of the annual financial statements, the general meeting shall hold a special vote on releasing the directors and, as applicable, the auditors. This release shall only be valid if the annual financial statements contain no omissions, nor any false statement concealing the company's actual condition and, in so far as concerns acts performed in violation of the articles of association, only if they have been specifically stated in the notice of meeting.

Within thirty days of their approval by the general meeting, the board of directors shall oversee the submission of the annual financial statements and, as applicable, the management report, as well as the other documents mentioned in the Code of Companies and Associations with Banque Nationale de Belgique (the National Bank of Belgium).

**<u>ARTICLE 36 – DISTRIBUTION</u>** 

From the net profit shown in the annual financial statements, annually an amount of five percent (5%) shall be withheld for the formation of the legal reserve, this withholding shall no longer be mandatory when the reserve reaches one tenth of the share capital.

When proposed by the board of directors, annually the balance shall be made available to the general meeting, who shall have sole authority to determine the allocation thereof by a simple majority of votes cast, within the limits imposed by the Code of Companies and Associations.

**<u>ARTICLE 37 – PAYMENT OF DIVIDENDS – INTERIM PAYMENTS</u>** 

Dividends are paid at such times and in such locations as designated by the board of directors.

The board of directors may, within the limits established by the Code of Companies and Associations, distribute one or more interim payments on the dividend which shall be distributed from the current fiscal year results.

**<u>ARTICLE 38 – EARLY DISSOLUTION</u>** 

If, subsequent to a loss, the net assets are reduced to an amount below one half of the share capital, the board of directors must submit the issue of the company's dissolution and eventually propose other measures to the general meeting deliberated as provided by the rules set forth in the Code of Companies and Associations.

The general meeting must be held within a period not to exceed two months starting from the time the loss was observed or should have been pursuant to the obligations of law or the articles of association.

If, subsequent to this loss, the net assets are reduced to an amount below one fourth of the share capital, dissolution may be pronounced by one fourth of votes cast at the general meeting.

When the net assets are reduced to an amount below the legal minimum for share capital, any interested party may request the company's dissolution in a court of law. The court may, as applicable, grant the company a delay so that the company may correct its situation.

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**<u>ARTICLE 39 – LIQUIDATION</u>** 

In the event of the company's dissolution, for any reason and at any time whatsoever, the liquidation shall proceed under the supervision of liquidators appointed by the general meeting. Unless decided otherwise, the liquidators shall act jointly. To this end, the liquidators shall possess the broadest powers pursuant to the applicable provisions of the Code of Companies and Associations, barring restrictions imposed by the general meeting.

The liquidator position shall be performed free of charge, except as decided otherwise by the general meeting.

**<u>ARTICLE 40 – DISTRIBUTION</u>** 

Following settlement of all debts, charges, and liquidation costs, the net assets shall firstly be applied to reimburse, whether in cash or in kind, the amount of shares that has been paid up and not yet reimbursed.

Any balance shall be distributed in equal proportion amongst all shares.

If the net proceeds do not allow the reimbursement of all shares, the liquidators shall make a priority reimbursement of paid-up shares in a greater proportion until they are on equal footing with the paid up shares in a lesser proportion or proceed with additional calls for funds made of the owners of the latter.

**<u>ARTICLE 41- ELECTION OF DOMICILE</u>** 

Any director, general manager, and liquidator domiciled or having his registered office abroad shall elected domicile, for the term of his mandate, at the registered office, where all notices and summons regarding the company's affairs and liability for his management may be validly made to him in his name, except for notices of meeting made in accordance with these articles of association.

Each director or executive director may elect domicile at the registered office of the legal person for all matters relating to the exercise of his or her term of office. This election of domicile is enforceable against third parties under the conditions set out in Article 2:18 of the Code of Companies and Associations.

Holders of registered shares or other registered securities issued by the company or with the company's collaboration are required to inform the company of any change in domicile or registered office. Failing this, they shall be considered to have elected domicile at their previous domicile or registered office.

**<u>ARTICLE 42 – ORDINARY LAW</u>** 

For anything that is not provided by these articles of association, reference shall be made to the Code of Companies and Associations.

Consequently, where no legal exemption has been made, the provisions of this Code shall be deemed to be incorporated into these articles of association and any clauses contrary to any mandatory provisions of this Code shall be deemed not to have been written.

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| |
|:---|
| **A CERTIFIED COORDINATED COPY** |
| **Peter Van Melkebeke** |
| **Partner Notary** |

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## Exhibit 4.25

**Exhibit 4.25**![LOGO](g418841g0314201638454.jpg)

**CELYAD ONCOLOGY SA** 

*Listed limited liability company* 

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WARRANTS PLAN 2022

Template

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Template of incentive plan to be used for any grant of subscription rights (**Warrants**) established in

accordance with the Companies and Associations Code and articles 41 to 47 of the Act of 26 March 1999

relating to the Belgian action plan for employment 1998 and having various provisions

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**PREAMBLE** 

This Warrant Plan of CELYAD ONCOLOGY SA (the "**Plan**") aims to motivate and inspire loyalty among the Beneficiaries. Well aware of the fact that their contribution is essential to the development of its activities and the growth of its results, the Company wishes to give the Beneficiaries the opportunity to become shareholder or to increase their participation, hoping to make a financial gain in the event of a positive evolution of the results and, consequently, the Company's value.

The Plan's principles have been determined by the Board of Directors and have been approved by the general shareholders' meeting.

In addition, the list of beneficiaries, as well as the exercise price of the Warrants will be determined by the Board of Directors prior to any offer.

The Plan is drawn up in accordance with the applicable provisions of the Belgian act of 26 March 1999 (and more precisely section VII hereof) governing the shares with a discount and stock-options (articles 41 to 47).

This Plan governs the terms and conditions of any grant of Warrants taking place for the 12 months period after its approval by the general shareholders' meeting.

The conditions governing the exercise of the Warrants must also be read in the light of the provisions of the "*Dealing Code*" which is applicable within the Company and available on the Company's website (<u>www.celyad.com</u>).

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1. **DEFINITIONS** 

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| | |
|:---|:---|
| **Share** | A new share of the Company, granting the same rights and advantages as the existing shares of the Company. |
| **Allocation** | The allocation of Warrants following the acceptance of an Offer. |
| **Bad Leaver** | Has the meaning given in article 8.6 of the Plan. |
| **Beneficiary** | A current Member of the Staff, of the management or of the Board of Directors of the Company, working as an employee, as a self-employed people or through a management company**,** to whom at least (1) Warrant has been allotted. |
| **Conditions for Exercice** | The conditions under which the Beneficiaries are entitled to exercise a Warrant during the Exercise Periods. |
| **Board of Directors** | The board of directors of the Company. |
| **Offer Letter** | The template attached hereto in Annex 1 – Offer letter. |
| **Reply Form** | The template attached hereto in Annex 2 – Reply form. |
| **Exercise Form** | The template attached hereto in Annex 3 – Exercise form. |
| **Good Leaver** | Has the meaning given in article 8.6 of the Plan. |
| **Act relating to Stock Options** | The Act of 26 March 1999 relating to the Belgian action plan for employment of 1998 and having various provisions. |
| **Member of the Staff** | Has the meaning provided under Article 1:27 of the new companies and associations Code |
| **Offer** | The offer of at least one (1) Warrant to one or more Beneficiaries, in accordance with the provisions of the Plan. |
| **Warrant** | A subscription right issued by the Company, granting the Beneficiaries the right to subscribe, in accordance with the terms and conditions as set out in the Plan, during the Exercise periods, to a number of Shares determined by the Plan, against payment of the Exercise Price. |
| **Exercice Period** | The period during which the Warrants may be exercised in accordance with the Plan. |
| **Plan** | This incentive plan. |

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| | |
|:---|:---|
| **Exercise Price** | The amount payable for the exercise of a Warrant pursuant to the Plan. |
| **Company** | Celyad Oncology SA, a public limited liability company, registered with the register of legal entities kept at the Crossroads Bank for Enterprises under number 0891.118.115 (RLE Brabant Wallon) and of which its shares are listed on EURONEXT Brussels and EURONEXT Paris. |
| **Affiliated Companies** | Means any company controlled by the Company. |

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2. **GENERAL MECHANISM OF THE OFFER OF WARRANTS** 

Pursuant to the Plan, the Company will allot to the Beneficiaries a certain number of Warrants. These Warrants are issued by decision of the general shareholders' meeting or by decision of the Board of Directors within the framework of the authorized capital. The Warrants are then allotted upon decision of the Board of Directors resolving on the recommendation of the Nomination and Remuneration Committee.

Each Warrant gives its holder the right (but not the obligation) to subscribe, under the Exercise Conditions, during the Exercise Periods and against payment of the Exercise Price, to one Share.

3. **BENEFICIARIES** 

The Warrants may be offered to any individual performing professional services, whether in principal or secondary, for the direct or indirect benefit of the Company or an Affiliated Company, in his capacity of an employee or future employee, in his capacity of a current or future self-employed people (as the case may be through a management company) or in his capacity of director.

The Warrants Offer does not create any right, on the part of the Beneficiaries, to receive (additional) Warrants in the future.

The Warrants Offer and the right to exercise these are not part of the employment agreement or service agreement concluded with the Company and therefore can not be considered as an acquired right. In addition, the Beneficiaries expressly accept that the decisions relating to the Warrants fall within the exclusive and discretionary competence of the Company. This grant shall not be taken into account in the calculation of any indemnity whatsoever which may be due to the Beneficiaries.

4. **CLOSED PERIOD** 

The eventual exercise of the Warrants shall take place in compliance with the terms and conditions imposed by the Company, and cannot in particular be exercised during the closed periods determined by the Company or by law.

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5. **WARRANTS** 

5.1 **Number of Warrants per Beneficiary** 

The number of Warrants offered to each of the Beneficiaries is freely determined by the Board of Directors, acting upon the recommendation of the Nomination and Remuneration Committee. As the case may be, the Board of Directors may empower the managing director (CEO) in order to determine the allocation of Warrants in favor of Beneficiaries other than members of the Board of Directors and members of the Executive Committee.

5.2 **Nature of the Warrants** 

The Warrants are exclusively in registered form. As soon as they are offered and accepted, the Warrants will be numbered and recorded in a special register, which will be kept up to date as regards the amount of Warrants held by each Beneficiary.

5.3 **Price of the Warrants** 

The Warrants will be allotted free of charge to the Beneficiaries.

5.4 **Term of the Warrants** 

Warrants are allotted for a limited term at their issuance. This term is limited to ten (10) years.

Notwithstanding this term, the Exercise Period is determined by the Board of Directors in accordance with the article 8.4.

Any Warrant that has not been exercised on its date of maturity may no longer be exercised without the Beneficiary being able to invoke any right to compensation.

5.5 **Non-transferability and securities** 

The Warrants are strictly personal and may not be transferred after the Offer, except in the event of death as provided in article 9 below.

Warrants may not be pledged or used as security, of any kind, as principal or accessory.

Warrants that may have been transferred, pledged or used as a security of any kind, whether as a principal or accessory, in violation of the provisions of this article 5.5, shall not be exercisable.

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6. **OFFER OF WARRANTS** 

6.1 **Date of the Offer** 

The Company will send each Beneficiary a personalized Offer Letter for a number of Warrants.

The Warrants are deemed to be offered to the Beneficiaries as from the date of dispatch of the Offer Letter.

6.2 **Acceptance or rejection of the Offer** 

The Beneficiary is free to accept the Offer, either in whole or in part, or to reject it.

A Reply Form is sent to each Beneficiary together with the Offer Letter, by which the Beneficiary notifies his decision as regards the Offer: acceptance (either in whole or in part) or rejection.

The Reply Form is delivered, completed and signed, at the latest on the date mentioned on the Reply Form, at the address mentioned therein.

The Offer of Warrants will be considered as altogether rejected if the Beneficiary did not accept the Offer in writing within sixty (60) days as from the date of the Offer, without the Beneficiary being able to claim any right to indemnification.

In case of absence of a signature, or if the Reply Form is not returned or is returned belatedly, the Offer will be considered as rejected as a whole.

From a Belgian tax point of view, the Stock Option Law considers that the Warrants are deemed to have been allotted on the sixtieth (60th) day following the date of the Offer, provided that the Beneficiary has notified in writing his acceptance of the Offer before expiry of this period. The acceptance of the Offer must be notified to the Company prior to the expiry of the sixty (60) days period referred to above, in accordance with this article 6.2, otherwise the Offer is deemed to be altogether rejected.

6.3 **Acceptance of the Plan** 

Acceptance of the Offer by the Beneficiary entails the unconditional acceptance of the Plan.

7. **ACQUISITION (VESTING) OF WARRANTS** 

Notwithstanding the Allocation of the Warrants to the Beneficiaries, the Warrants are acquired by the Beneficiaries, subject to compliance with the Conditions for Exercise provided for in article 8 and without prejudice to an eventual acceleration as provided under article 8.8, in accordance with the following terms:

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• If the Beneficiary stops exercising his professional activities for the benefit of the Company before the first
anniversary of the Offer, the Warrants awarded to him shall be qualified as void and they cannot be exercised anymore;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• If the Beneficiary stops exercising his professional activities for the benefit of the Company during the second
year after the Offer, 33% of the Warrants awarded to him shall be considered as vested;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• If the Beneficiary stops exercising his professional activities for the benefit of the Company during the third
year after the Offer, 66% of the Warrants awarded to him shall be considered as vested;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• If the Beneficiary still exercises his professional activities for the benefit of the Company after the third
anniversary of the Offer, 100% of the Warrants awarded to him shall be considered as vested.

For the purposes of this article the Beneficiary shall no longer be deemed to be carrying on his professional activity for the benefit of the Company as from the date on which he issued or received a notice of termination of his employment agreement or on the date of the termination of the service agreement.

8. **THE EXERCICE OF WARRANTS** 

8.1 **Conditions for Exercice** 

The exercise of Warrant is subject to Conditions for Exercise provided for in the Plan.

8.2 **Exercice Price** 

The Exercise Price is equal to the fair market value of the Company's shares at the time of the Offer. This value is determined by the Board of Directors and corresponds to the lower of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• either the closing price of the Company's Share on the day before the date of the Offer;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• or the average of the thirty (30) calendar days preceding the date of the Offer of the closing price of the
Company's Share.

The exercise price of each Warrant will be stipulated in the Letter of Offer to each Beneficiary.

8.3 **Consequences of the Exercice** 

In the event of exercise of the Warrants, the Shares issued in consideration for the exercise will be in registered or dematerialized form according to the decision of the Beneficiaries. Such Shares shall have the same characteristics as the existing Shares of the Company.

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8.4 **Exercise Period** 

Without prejudice to article 8.8 of the Plan, the Exercise Period will be determined by the Board of Directors prior to each Offer of Warrants. This Exercise Period will be specified in the Offer Letter. Without prejudice to article 8.8 of the Plan, the Warrants will be exercisable between the first day of the fourth calendar year following the Offer and the last day of the tenth calendar year following the Offer (the "**Exercise Period**").

Without prejudice to the respect of the Exercise Period, and in order to streamline the exercise of the Warrants and to limit the costs associated with their exercise, the exercise of the Warrants and the corresponding capital increases may only take place during exercise windows (the "**Exercise Windows**") corresponding to the first month of each quarter during the Exercise Period.

Where relevant, the exercise of the Warrants will be recorded by notary deed within a maximum of thirty (30) days following the closing of each Exercise Window.

8.5 **Number of Shares per Warrant** 

One (1) Warrant gives right to subscribe to (1) Share.

8.6 **Attendance – Good Leaver and Bad Leaver** 

8.6.1 In the event that the employment agreement or service agreement between the Company (or one of its Affiliated
Companies) and a Beneficiary (or management company of a Beneficiary) comes to an end:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) as a result of death, incapacity, retirement, termination of the employment agreement or service agreement
without any serious misconduct of the Beneficiary, resignation of the Beneficiary or unilateral breach by the Beneficiary of his employment agreement or service agreement, the Beneficiary shall be referred to as "**Good Leaver** ";

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) for any reason other than those set forth in (a) above, including the termination of the employment or
service agreement by the Company due to serious misconduct of the Beneficiary, the Beneficiary will be referred to as "**Bad Leaver** ".

The qualification as Good Leaver or Bad Leaver will take place on the date of the determination of the above situation, namely on the date on which the event is brought to the attention of the parties. In this regard, the Beneficiary is referred to as Good / Bad Leaver on the date of notification of termination of his contract, even if he must then provide a notice period.

With regards to the people enjoying the status of Beneficiary because they are Director or provide products or services to the Company as a self-employed but on a regular basis (or, when appropriate, via a management or services company), the words "dismissal or revocation" and "voluntary termination" refer to the various hypotheses in which a contract for the delivery of these products or services is being terminated permanently either by the

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Company or by the Beneficiary or the management or services company. The words "serious misconduct" refer to the hypothesis in which this termination is based on a serious breach by the Beneficiary or the management or services company of their contractual obligations. An interruption of more than six (6) months in the delivery of the products or the services is considered as a permanent termination.

In case the labor contract is suspended for more than six (6) months in total, the consequences of said suspension on the rights related to the Warrants granted by the Company will be determined individually by the Company.

8.6.2 Notwithstanding the realization of the vesting provided for in article 7 of the Plan, Warrants can no longer be
exercised in the event that the Beneficiary is considered to be a Bad Leaver prior to the exercise of the Warrants.

8.6.3 **Terms of Exercise** 

A Beneficiary willing to exercise its Warrants will specify, upon their exercise, the numbers of the Warrants that he intends to exercise. In situations where the Beneficiary does not specify the numbers, the Beneficiary will be deemed to have exercised its Warrants in the chronological order in which they were allocated, from the oldest to the most recent.

The Warrants can be exercised upon delivering an Exercise Form to the Company, for the attention of the Board of Directors. The Exercise Form can be (i) delivered in person with delivery receipt, (ii) sent by registered mail or (ii) faxed with immediate confirmation by registered mail.

The Exercise Form must be completed in full and signed by the Beneficiary, and must mention the number of Warrants that the Beneficiary intends to exercise.

8.7 **Terms of payment** 

The payment shall be made by bank transfer of the Price of Exercise of all exercised Warrants to the Company's account as indicated by the latter in the Exercise Form.

The Beneficiary shall have a period of ten (10) days as from the sending of the Exercise Form to proceed with the payment.

8.8 **Acceleration of the vesting and exercise of the Warrants** 

Notwithstanding the delays and periods provided under articles 7 and 8.4 of the Plan, the Warrants can be immediately exercised by the Beneficiaries in the following situations:

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Share capital increase in cash without restriction or cancellation of the preferential rights of the existing
shareholders;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Takeover bid on the Shares of the Company as of the announcement of the public offer by the FSMA;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Change of control on the Company;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) Conclusion of a "Strategic Partnership" with an important industrial actor, active in the
life-science sector, and if the "Strategic Partnership" is qualified as such by the Board of Directors.

As soon as possible and from the occurrence of one of these events at the latest, the Company shall notify the Beneficiaries in order to allow them to exercise their Warrants for a minimum ten (10) days period since notification. If the Warrants are not exercised during these ten (10) days period they will only be exercised under the conditions provided by articles 7 and 8.4 of the Plan.

The new shares issued further to the exercise of the Warrants under the present article 8.8 can be, upon decision of their holder, immediately dematerialised, listed and traded on the market.

The eventual tax consequences of the acceleration of the vesting and exercise will be borne by the concerned Beneficiaries.

9. **DEATH OF THE BENEFICIARY** 

In the event of the death of the Beneficiary, its Warrants can be exercised by its designated legal successors. Successors and assigns are subject to the same rules than the Beneficiaries.

In the event of the death of the Beneficiary prior to the exercise of Warrants, the provisions of article 7 (vesting) will not be applicable. Legal heirs will therefore be able to exercise 100% of the Warrants that were allocated to the deceased Beneficiary.

The rules of succession will be followed. However, where they are several legal heirs or where bare property rights/usufruct have been separated, a sole representative of the succession will be appointed by the successors and assigns for the purpose of exercising the Warrants.

The Company reserves the right to suspend the right to exercise the Warrants as long as this appointment has not taken place and as long as it has not been duly notified.

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10. **NATURE OF THE SHARES ISSUED UPON THE EXERCISE OF THE WARRANTS** 

10.1 **Nature of the Shares** 

The Shares are shares identical to the other shares issued by the Company.

10.2 **Rights attached to the Shares** 

The Shares issued upon the exercise of the Warrants will benefit from the same rights and advantages (including voting rights) than the existing Shares of the Company.

10.3 **Transferability of the Shares** 

The transfer of Shares is subject to the terms and conditions defined in the articles of association of the Company.

11. **OPERATIONS AUTHORISED** 

Without prejudice to the legally prescribed exceptions, the Company may pass all resolutions that it deems necessary in relation to its capital, its articles of association or its management. Such resolutions may include, amongst others, capital reduction, with or without reimbursement for the shareholders, a capital increase by way of incorporation of reserves whether or not with the issue of new shares, a capital increase in kind, a capital increase in cash with or without restriction or cancellation of the preferential subscription rights of the shareholders, the issuance of profit shares, convertible bonds, preferred shares, bonds cum warrants or conventional bonds or warrants, an amendment the provisions of the articles of associations with regards to the distribution of the profits or the (net) liquidation proceeds or other rights attached to the common shares, a splitting of shares, a payment of dividend in shares, the dissolution of the Company, a legal merger, a legal demerger or a contribution or transfer of a universality or a branch of activity whether or not combined with the exchange of shares. The Company may pass such resolutions even if these implied or may imply that the benefits for the Warrant holder arising from the issuance and the Warrant exercise provisions or the law may be reduced unless such reduction is, in an obvious way, the sole objective of such a resolution.

However, in the event of a merger or demerger, the Board of Directors has an obligation of means to ensure that the Warrants outstanding at the date of these transactions are adjusted in accordance with the exchange ratio applied to the Company's existing shares.

Moreover, in case of a capital reduction or any similar transaction resulting into a decrease of the Company's equity as a result of a decision of the shareholders taken by the general assembly, the exercise price of the Warrants may be modified by decision of the Board of Directors notified to the Beneficiaries in order to compensate for the loss of value resulting from the equity decrease. The possible amendment will be applicable as soon as the Beneficiaries have been notified, without them having to formally accept it.

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Finally, the number of shares corresponding to the Warrants will be adjusted to reflect and take into account any increase or decrease in the number of shares of the Company resulting from a demerger or regrouping, as the case may be.

12. **COSTS** 

12.1 **The Company** 

All costs associated with the issue of Warrants will be borne by the Company.

If the underlying Shares are delivered on a securities account, the subscribed Shares will be delivered free of charge insofar as the account is being held at a financial institution in Belgium.

12.2 **The Beneficiaries** 

Nihil.

13. **INTERPRETATION OR AMENDMENT OF THE PLAN** 

The Board of Directors is competent for making any decision deemed useful or necessary in order to interpret, amend or implement the Plan in compliance with all applicable laws. Any decision having legal effect will be communicated in writing to the Beneficiaries concerned.

14. **INFORMATION OF BENEFICIARIES** 

The Allocation of Warrants is not, on the part of the Company, an incentive or a recommendation to subscribe to the Warrants, nor to exercise them subsequently. The Beneficiaries are consequently invited to inform themselves and, as the case may be, to be advised to make decisions likely to have a significant effect on their assets.

The Company cannot be held liable for any damage or losses possibly incurred by the Beneficiaries on account of their participation to the Plan.

15. **INVALIDITY OF A PROVISION** 

The invalidity or unenforceability of one of the provisions of the present Plan does not affect in any manner the validity or enforceability of the other provisions of the Plan. In such cases, the invalid or unenforceable provision will be replaced by another equivalent provision, valid and enforceable, with a similar economic effect for the parties concerned.

16. **NOTIFICATIONS** 

Any notification to the holders of Warrants will be made to the address mentioned in the subscription rights register of the Company. Any notification to the Company or Board of Directors will be duly carried out to the address of the registered office of the Company.

------

Any changes of address must be notified in compliance with the present provision.

17. **APPLICABLE LAW AND JURISDICTION** 

17.1 **Applicable law** 

The Plan and the Warrants are governed by Belgian law.

17.2 **Jurisdiction** 

Any dispute arising out of the interpretation, execution, application, validity or resolution of the Plan shall be subject exclusively to the court of the judicial district of the registered office of the Company.

------

**Annex 1 – Offer Letter** 

[**Date**]

**Re : Offer of Warrants** 

The Company Celyad Oncology SA is pleased to offer you [•] Warrants, at a price of exercise of [•] EUR per Warrant.

The terms governing these Warrants are contained in the Plan, a copy of which is enclosed.

The Exercise Period is: [•].

By way of indication, you shall note that the value of the Shares which will be taken into account for the calculation of the taxable benefit, in particular for the determination of the professional withholding tax by the Company, amounts to [•] EUR per Warrant.

The Reply Form annexed hereto must be sent within sixty (60) days as from the Offer, completed in full and signed, to Celyad Oncology SA, for the attention of the Board of Directors.

Please bear in mind that, in the absence of a signature, in the absence of a delivery or in case of tardy delivery of the Reply Form, the Warrants will be deemed to be refused in their entirety.

---

| |
|:---|
| Sincerely yours, |
| Celyad Oncology SA, |

---

------

**Annex 2 – Reply Form** 

**Allocation** 

The undersigned<u> </u> (***NAME***)

Domiciled in :

<u> </u>

<u> </u> (***FULL ADDRESS***)

hereby declares that he/she is aware of the incentive Plan put in place by the Company Celyad Oncology SA and accepts the terms and conditions of the Offer as provided for in the Plan.

The undersigned hereby notifies its decision as regards the Allocation dated<u> </u> (***DATE***).

He/She declares that :

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• he/she accepts the <u> </u> Warrants offered

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• he/she accepts <u> </u> of <u> </u> Warrants offered

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• refuses all <u> </u> Warrants offered

*(Complete and delete as appropriate)* 

The undersigned acknowledges that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• the acceptance of the Offer of Warrants is a taxable benefit and that he/she will be for the payment of taxes in
connection with the Warrants;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• the Price of Exercise of the Warrants is set at [●] EUR per Warrant;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• each Warrant allows for the subscription to 1 Share Celyad.

Done in<u> </u> on<u> </u> .

Signature

------

**Annex 3 – Exercise Form** 

**INCENTIVE PLAN – CELYAD ONCOLOGY SA** 

The undersigned<u> </u> (***NAME***)

Domiciled in :<u> </u>

<u> </u> (***FULL ADDRESS***)

Hereby declares that he/she exercises the following Warrants, pursuant to the terms provided for in the incentive Plan dated<u> </u> (***DATE***):

<u> </u> (***NUMBER***) Warrants, allocated on<u> </u> (***DATE***) at a Price of Exercise of<u> </u> (***AMOUNT***) EUR =<u> </u> (***AMOUNT***) EUR

Total amount:<u> </u> EUR

This amount will be paid to the bank account N° [•] (***NUMBER***) with value dated at the latest on [•] (***DATE***).

I hereby acknowledge that if the above mentioned amount is overdue or is not paid in full on [•] (***DATE***), the exercise will not take place.

Done in<u> </u> on<u> </u>

Signature

## Exhibit 12.1

**Exhibit 12.1** 

***Certification by the Principal Executive Officer pursuant to Securities***

***Exchange Act Rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of the Sarbanes-***

***Oxley Act of 2002***

I, Michel Lussier, certify that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. I have reviewed this annual report on Form 20-F of Celyad Oncology SA;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a
material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3. Based on my knowledge, the financial statements, and other financial information included in this report,
fairly present in all material respects the financial condition, results of operations and cash flows of the company as of, and for, the periods presented in this report;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4. The company's other certifying officer(s) and I are responsible for establishing and maintaining
disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act
Rules 13a-15(f) and 15d-15(f)) for the company and have:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a. Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be
designed under our supervision, to ensure that material information relating to the company, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being
prepared;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b. Designed such internal control over financial reporting, or caused such internal control over financial
reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting
principles;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;c. Evaluated the effectiveness of the company's disclosure controls and procedures and presented in this
report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;d. Disclosed in this report any change in the company's internal control over financial reporting that
occurred during the period covered by the annual report that has materially affected, or is reasonably likely to materially affect, the company's internal control over financial reporting; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5. The company's other certifying officer(s) and I have disclosed, based on our most recent evaluation of
internal control over financial reporting, to the company's auditors and the audit committee of the company's board of directors (or persons performing the equivalent functions):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a. All significant deficiencies and material weaknesses in the design or operation of internal control over
financial reporting which are reasonably likely to adversely affect the company's ability to record, process, summarize and report financial information; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b. Any fraud, whether or not material, that involves management or other employees who have a significant role in
the company's internal control over financial reporting

Date: March 23, 2023

/s/ Michel Lussier<br>

Name: Michel Lussier

Title: Interim Chief Executive Officer *(Principal Executive Officer)*

## Exhibit 12.2

**Exhibit 12.2** 

***Certification by the Principal Financial Officer pursuant to Securities***

***Exchange Act Rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of the Sarbanes-***

***Oxley Act of 2002***

I, David Georges, certify that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. I have reviewed this annual report on Form 20-F of Celyad Oncology SA;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a
material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3. Based on my knowledge, the financial statements, and other financial information included in this report,
fairly present in all material respects the financial condition, results of operations and cash flows of the company as of, and for, the periods presented in this report;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4. The company's other certifying officer(s) and I are responsible for establishing and maintaining
disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act
Rules 13a-15(f) and 15d-15(f)) for the company and have:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a. Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be
designed under our supervision, to ensure that material information relating to the company, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being
prepared;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b. Designed such internal control over financial reporting, or caused such internal control over financial
reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting
principles;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;c. Evaluated the effectiveness of the company's disclosure controls and procedures and presented in this
report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;d. Disclosed in this report any change in the company's internal control over financial reporting that
occurred during the period covered by the annual report that has materially affected, or is reasonably likely to materially affect, the company's internal control over financial reporting; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5. The company's other certifying officer(s) and I have disclosed, based on our most recent evaluation of
internal control over financial reporting, to the company's auditors and the audit committee of the company's board of directors (or persons performing the equivalent functions):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a. All significant deficiencies and material weaknesses in the design or operation of internal control over
financial reporting which are reasonably likely to adversely affect the company's ability to record, process, summarize and report financial information; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b. Any fraud, whether or not material, that involves management or other employees who have a significant role in
the company's internal control over financial reporting

Date: March 23, 2023

/s/ David Georges<br>

Name: David Georges

Title: Vice President of Finance and Administration *(Principal Financial Officer)*

## Exhibit 13.1

**Exhibit 13.1** 

**Certification by the Principal Executive Officer pursuant to 18** 

**U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002** 

In connection with the annual report of Celyad SA (the "Company") on Form 20-F for the fiscal year ended December 31, 2022 as filed with the U.S. Securities and Exchange Commission on the date hereof (the "Report"), I, Michel Lussier, Interim Chief Executive Officer of the Company, certify, pursuant to 18 U.S.C § 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to my knowledge:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act
of 1934; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. The information contained in the Report fairly presents, in all material respects, the financial condition and
results of operations of the Company.

Date: March 23, 2023

---

| |
|:---|
| /s/ Michel Lussier |
| Name: Michel Lussier |
| Title: Interim Chief Executive Officer (*Principal Executive Officer*) |

---

## Exhibit 13.2

**Exhibit 13.2** 

**Certification by the Principal Financial Officer pursuant to 18** 

**U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002** 

In connection with the annual report of Celyad SA (the "Company") on Form 20-F for the fiscal year ended December 31, 2022 as filed with the U.S. Securities and Exchange Commission on the date hereof (the "Report"), I, David Georges, Vice President of Finance and Administration of the Company, certify, pursuant to 18 U.S.C § 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to my knowledge:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act
of 1934; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. The information contained in the Report fairly presents, in all material respects, the financial condition and
results of operations of the Company.

Date: March 23, 2023

---

| |
|:---|
| /s/ David Georges |
| Name: David Georges |
| Title: Vice President of Finance and Administration (*Principal Financial Officer*) |

---

## Exhibit 15.1

**Exhibit 15.1** 

**Consent of independent registered public accounting firm** 

We consent to the incorporation by reference in the following Registration Statements:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) Registration Statement (Form F-3 No. 333-248464) of Celyad Oncology SA, and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) Registration Statement (Form S-8 No. 333-220737) pertaining to the Warrants plan 2017

of our reports dated March 23, 2023, with respect to the consolidated financial statements of Celyad Oncology SA included in this Annual Report (Form 20-F) of Celyad Oncology SA for the years ended December 31, 2022.

/s/ EY Réviseurs d'Entreprises / EY Bedrijfsrevisoren SRL/BV

Diegem, Belgium

March 23, 2023

## Exhibit 16.1

**Exhibit 16.1** 

March 23, 2023

Securities and Exchange Commission

100 F Street, N.E.

Washington, DC 20549

Ladies and Gentlemen:

We have read Item 16F. Change in Registrant's Certifying Accountant on page 145 of Form 20-F dated March 23, 2023, of Celyad Oncology SA and are in agreement with the statements contained in paragraphs one, four, five, six and seven. We have no basis to agree or disagree with other statements of the registrant contained therein.

/s/ EY Réviseurs d'Entreprises / EY Bedrijfsrevisoren SRL/BV