# EDGAR Filing Document

**Accession Number:** 0001378872
**File Stem:** 0001378872-25-000320
**Filing Date:** 2025-10
**Character Count:** 94461
**Document Hash:** 6f43d251d6ea21babcba69ea1740af5c
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001378872-25-000320.hdr.sgml**: 20251028

**ACCESSION NUMBER**: 0001378872-25-000320

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20250831

**FILED AS OF DATE**: 20251028

**DATE AS OF CHANGE**: 20251028

**PERIOD START**: 20250831

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Invesco Exchange-Traded Fund Trust II
- **CENTRAL INDEX KEY:** 0001378872

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **FISCAL YEAR END:** 1031

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-21977
- **FILM NUMBER:** 251422028

**BUSINESS ADDRESS:**
- **STREET 1:** 3500 LACEY ROAD
- **STREET 2:** SUITE 700
- **CITY:** DOWNERS GROVE
- **STATE:** IL
- **ZIP:** 60515
- **BUSINESS PHONE:** 800-983-0903

**MAIL ADDRESS:**
- **STREET 1:** 3500 LACEY ROAD
- **STREET 2:** SUITE 700
- **CITY:** DOWNERS GROVE
- **STATE:** IL
- **ZIP:** 60515

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** PowerShares Exchange-Traded Fund Trust II
- **DATE OF NAME CHANGE:** 20070919

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** PowerShares Global Exchange-Traded Fund Trust
- **DATE OF NAME CHANGE:** 20061023

## Series and Classes Contracts Data

### Invesco Nasdaq Biotechnology ETF (Series ID: S000072469)

| Class ID   | Class Name                       | Ticker Symbol   |
|:---|:---|:---|
| C000228754 | Invesco Nasdaq Biotechnology ETF | IBBQ            |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** Invesco Exchange-Traded Fund Trust II

- **b. Investment Company Act file number:** 811-21977

- **c. CIK number of Registrant:** 0001378872

- **d. LEI of Registrant:** O540V2L4S174Y60FMD36

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 3500 Lacey Road

  - **City:** Downers Grove

  - **State:** IL

  - **Foreign country:** US

  - **Zip / Postal Code:** 60515

  - **Telephone number:** 800-983-0903

**Item A.2. Information about the Series.**

- **a. Name of Series:** Invesco Nasdaq Biotechnology ETF

- **b. EDGAR series identifier (if any):** S000072469

- **c. LEI of Series:** 549300GYFD12WC2CZH57

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2025-08-31

- **b. Date as of which information is reported:** 2025-08-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $42660923.37

**Total Liabilities:** $6882572.16

**Net Assets:** $35778351.21

**Cash Not Reported:** $8598.09

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000228754 | 3.67%                | 5.54%                | 4.94%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $-59437.79               | $1353162.42                                |
| Month 2  | $1423797.72              | $608711.75                                 |
| Month 3  | $-28625.23               | $1677065.41                                |

### Schedule of Portfolio Investments

| Name                                       | Title                                                      | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| AstraZeneca PLC                            | AstraZeneca PLC, ADR                                       | CUSIP: 046353108<br>LEI: PY6ZZQWO2IZFZC3IOL08 | Long             | EC               | CORP              | GB        |     21503 | NS      | $1718089.70   | 4.80%             |  |  |  | No            |                  1 | On Loan: No      |
| Rocket Pharmaceuticals, Inc.               | Rocket Pharmaceuticals, Inc.                               | CUSIP: 77313F106<br>LEI: 549300R7VV82YUIN4Y93 | Long             | EC               | CORP              | US        |      3886 | NS      | $12746.08     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Esperion Therapeutics, Inc.                | Esperion Therapeutics, Inc.                                | CUSIP: 29664W105<br>LEI: 549300OFU56UKEWVUS92 | Long             | EC               | CORP              | US        |      7126 | NS      | $15819.72     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Insmed Inc.                                | Insmed Inc.                                                | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |      6629 | NS      | $902206.90    | 2.52%             |  |  |  | No            |                  1 | On Loan: No      |
| Tempus AI, Inc.                            | Tempus AI, Inc.                                            | CUSIP: 88023B103<br>LEI: 2549009LA0KWRAGQBX50 | Long             | EC               | CORP              | US        |      6125 | NS      | $464642.50    | 1.30%             |  |  |  | No            |                  1 | On Loan: —       |
| Collegium Pharmaceutical, Inc.             | Collegium Pharmaceutical, Inc.                             | CUSIP: 19459J104<br>LEI: 54930049FXZMTLW8D496 | Long             | EC               | CORP              | US        |      1170 | NS      | $45396.00     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Design Therapeutics, Inc.                  | Design Therapeutics, Inc.                                  | CUSIP: 25056L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2051 | NS      | $11342.03     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Aura Biosciences, Inc.                     | Aura Biosciences, Inc.                                     | CUSIP: 05153U107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2223 | NS      | $13915.98     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Entrada Therapeutics Inc.                  | Entrada Therapeutics Inc.                                  | CUSIP: 29384C108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1365 | NS      | $7466.55      | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Personalis, Inc.                           | Personalis, Inc.                                           | CUSIP: 71535D106<br>LEI: 549300EZ2NYFK7H0US48 | Long             | EC               | CORP              | US        |      3175 | NS      | $15525.75     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Harrow, Inc.                               | Harrow, Inc.                                               | CUSIP: 415858109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1338 | NS      | $52182.00     | 0.15%             |  |  |  | No            |                  1 | On Loan: —       |
| Fortrea Holdings Inc.                      | Fortrea Holdings Inc.                                      | CUSIP: 34965K107<br>LEI: 5493000FIVFABOVCDU97 | Long             | EC               | CORP              | US        |      3264 | NS      | $32150.40     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Ligand Pharmaceuticals Inc.                | Ligand Pharmaceuticals Inc.                                | CUSIP: 53220K504<br>LEI: 5493008K7TB0IKP37H79 | Long             | EC               | CORP              | US        |       710 | NS      | $114814.10    | 0.32%             |  |  |  | No            |                  1 | On Loan: No      |
| Dynavax Technologies Corp.                 | Dynavax Technologies Corp.                                 | CUSIP: 268158201<br>LEI: 549300T5URIXWDILX594 | Long             | EC               | CORP              | US        |      4328 | NS      | $43799.36     | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Tourmaline Bio, Inc.                       | Tourmaline Bio, Inc.                                       | CUSIP: 89157D105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       926 | NS      | $21668.40     | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Amphastar Pharmaceuticals, Inc.            | Amphastar Pharmaceuticals, Inc.                            | CUSIP: 03209R103<br>LEI: 54930055TH0ZLSAQMJ38 | Long             | EC               | CORP              | US        |      1699 | NS      | $52023.38     | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences, Inc.               | Neurocrine Biosciences, Inc.                               | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |      3603 | NS      | $502978.80    | 1.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Adaptive Biotechnologies Corp.             | Adaptive Biotechnologies Corp.                             | CUSIP: 00650F109<br>LEI: 549300ZTF7OT1FW66Q96 | Long             | EC               | CORP              | US        |      5463 | NS      | $72002.34     | 0.20%             |  |  |  | No            |                  1 | On Loan: —       |
| Y-mAbs Therapeutics, Inc.                  | Y-mAbs Therapeutics, Inc.                                  | CUSIP: 984241109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1623 | NS      | $13876.65     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| CorMedix Inc.                              | CorMedix Inc.                                              | CUSIP: 21900C308<br>LEI: 5299006YIA3L0MBW8358 | Long             | EC               | CORP              | US        |      2440 | NS      | $36185.20     | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| Mirum Pharmaceuticals, Inc.                | Mirum Pharmaceuticals, Inc.                                | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |      1821 | NS      | $134517.27    | 0.38%             |  |  |  | No            |                  1 | On Loan: —       |
| Axsome Therapeutics, Inc.                  | Axsome Therapeutics, Inc.                                  | CUSIP: 05464T104<br>LEI: 549300EXGR0XLRJEIB95 | Long             | EC               | CORP              | US        |      1794 | NS      | $217576.32    | 0.61%             |  |  |  | No            |                  1 | On Loan: No      |
| Atea Pharmaceuticals, Inc.                 | Atea Pharmaceuticals, Inc.                                 | CUSIP: 04683R106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3084 | NS      | $10362.24     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Vir Biotechnology, Inc.                    | Vir Biotechnology, Inc.                                    | CUSIP: 92764N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4963 | NS      | $24517.22     | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| OnKure Therapeutics, Inc.                  | OnKure Therapeutics, Inc.                                  | CUSIP: 68277Q105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       462 | NS      | $1270.50      | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Disc Medicine, Inc.                        | Disc Medicine, Inc.                                        | CUSIP: 254604101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1250 | NS      | $74556.25     | 0.21%             |  |  |  | No            |                  1 | On Loan: —       |
| Acadia Pharmaceuticals Inc.                | Acadia Pharmaceuticals Inc.                                | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |      6078 | NS      | $157967.22    | 0.44%             |  |  |  | No            |                  1 | On Loan: No      |
| Bicycle Therapeutics PLC                   | Bicycle Therapeutics PLC, ADR                              | CUSIP: 088786108<br>LEI: 213800XKUI6R7GKC3E43 | Long             | EC               | CORP              | GB        |      1597 | NS      | $11785.86     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Apellis Pharmaceuticals, Inc.              | Apellis Pharmaceuticals, Inc.                              | CUSIP: 03753U106<br>LEI: 254900HS0ZFRXXSB9D42 | Long             | EC               | CORP              | US        |      4625 | NS      | $127511.25    | 0.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Cullinan Therapeutics, Inc.                | Cullinan Therapeutics, Inc.                                | CUSIP: 230031106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2122 | NS      | $15999.88     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Vera Therapeutics, Inc.                    | Vera Therapeutics, Inc.                                    | CUSIP: 92337R101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2296 | NS      | $49685.44     | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Humacyte, Inc.                             | Humacyte, Inc.                                             | CUSIP: 44486Q103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5598 | NS      | $8676.90      | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Alector, Inc.                              | Alector, Inc.                                              | CUSIP: 014442107<br>LEI: 549300Z8RQOIY1JMHC25 | Long             | EC               | CORP              | US        |      3586 | NS      | $8427.10      | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Ardelyx, Inc.                              | Ardelyx, Inc.                                              | CUSIP: 039697107<br>LEI: 549300F542QR4SXHCY32 | Long             | EC               | CORP              | US        |      8619 | NS      | $54816.84     | 0.15%             |  |  |  | No            |                  1 | On Loan: —       |
| LENZ Therapeutics, Inc.                    | LENZ Therapeutics, Inc.                                    | CUSIP: 52635N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1005 | NS      | $38823.15     | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| Arvinas, Inc.                              | Arvinas, Inc.                                              | CUSIP: 04335A105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2631 | NS      | $20337.63     | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Prothena Corp. PLC                         | Prothena Corp. PLC                                         | CUSIP: G72800108<br>LEI: 5299009ZXQ8NIIJ8OL30 | Long             | EC               | CORP              | IE        |      1930 | NS      | $15826.00     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Olema Pharmaceuticals, Inc.                | Olema Pharmaceuticals, Inc.                                | CUSIP: 68062P106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2465 | NS      | $13458.90     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Beam Therapeutics Inc.                     | Beam Therapeutics Inc.                                     | CUSIP: 07373V105<br>LEI: 254900QL5GLNKGR8YH71 | Long             | EC               | CORP              | US        |      3667 | NS      | $59992.12     | 0.17%             |  |  |  | No            |                  1 | On Loan: —       |
| 10x Genomics, Inc.                         | 10x Genomics, Inc., Class A                                | CUSIP: 88025U109<br>LEI: 5493003Z6741WNLG7H43 | Long             | EC               | CORP              | US        |      4002 | NS      | $56068.02     | 0.16%             |  |  |  | No            |                  1 | On Loan: —       |
| MacroGenics, Inc.                          | MacroGenics, Inc.                                          | CUSIP: 556099109<br>LEI: 5493001KJQUA83L8MH79 | Long             | EC               | CORP              | US        |      2268 | NS      | $4014.36      | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Enanta Pharmaceuticals, Inc.               | Enanta Pharmaceuticals, Inc.                               | CUSIP: 29251M106<br>LEI: 529900SSN4DODDQSN594 | Long             | EC               | CORP              | US        |       770 | NS      | $6468.00      | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals Inc.                | Vertex Pharmaceuticals Inc.                                | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |      5699 | NS      | $2228422.98   | 6.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Zevra Therapeutics, Inc.                   | Zevra Therapeutics, Inc.                                   | CUSIP: 488445206<br>LEI: 254900CU6T74V18Y1W18 | Long             | EC               | CORP              | US        |      1965 | NS      | $17822.55     | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Immunovant, Inc.                           | Immunovant, Inc.                                           | CUSIP: 45258J102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6220 | NS      | $91371.80     | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| BioMarin Pharmaceutical Inc.               | BioMarin Pharmaceutical Inc.                               | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |      7003 | NS      | $408064.81    | 1.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Omeros Corp.                               | Omeros Corp.                                               | CUSIP: 682143102<br>LEI: 549300CJWLXX2MXVVV71 | Long             | EC               | CORP              | US        |      2104 | NS      | $8752.64      | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Arcturus Therapeutics Holdings Inc.        | Arcturus Therapeutics Holdings Inc.                        | CUSIP: 03969T109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       985 | NS      | $16754.85     | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Kyverna Therapeutics, Inc.                 | Kyverna Therapeutics, Inc.                                 | CUSIP: 501976104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1559 | NS      | $5783.89      | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Ironwood Pharmaceuticals, Inc.             | Ironwood Pharmaceuticals, Inc.                             | CUSIP: 46333X108<br>LEI: 549300PC8MR6QHH6P296 | Long             | EC               | CORP              | US        |      5826 | NS      | $7690.32      | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Praxis Precision Medicines, Inc.           | Praxis Precision Medicines, Inc.                           | CUSIP: 74006W207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       729 | NS      | $33198.66     | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Xeris Biopharma Holdings, Inc.             | Xeris Biopharma Holdings, Inc.                             | CUSIP: 98422E103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5758 | NS      | $45085.14     | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Phathom Pharmaceuticals, Inc.              | Phathom Pharmaceuticals, Inc.                              | CUSIP: 71722W107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2522 | NS      | $30717.96     | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Nuvalent, Inc.                             | Nuvalent, Inc., Class A                                    | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2419 | NS      | $185247.02    | 0.52%             |  |  |  | No            |                  1 | On Loan: No      |
| Mersana Therapeutics, Inc.                 | Mersana Therapeutics, Inc.                                 | CUSIP: 59045L205<br>LEI: 529900VWD5VDZ7PVOS22 | Long             | EC               | CORP              | US        |       179 | NS      | $1310.28      | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Regeneron Pharmaceuticals, Inc.            | Regeneron Pharmaceuticals, Inc.                            | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |      3830 | NS      | $2224081.00   | 6.22%             |  |  |  | No            |                  1 | On Loan: No      |
| ImmunityBio, Inc.                          | ImmunityBio, Inc.                                          | CUSIP: 45256X103<br>LEI: 529900J9XLBR4HFL4B83 | Long             | EC               | CORP              | US        |     32165 | NS      | $75266.10     | 0.21%             |  |  |  | No            |                  1 | On Loan: —       |
| Xencor, Inc.                               | Xencor, Inc.                                               | CUSIP: 98401F105<br>LEI: 549300V5IF65437JKG30 | Long             | EC               | CORP              | US        |      2556 | NS      | $20780.28     | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| COMPASS Pathways PLC                       | COMPASS Pathways PLC, ADR                                  | CUSIP: 20451W101<br>LEI: 213800N7CUZIC6QSTZ31 | Long             | EC               | CORP              | GB        |      3284 | NS      | $14515.28     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| C4 Therapeutics, Inc.                      | C4 Therapeutics, Inc.                                      | CUSIP: 12529R107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2550 | NS      | $6630.00      | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Gilead Sciences, Inc.                      | Gilead Sciences, Inc.                                      | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |     22881 | NS      | $2584866.57   | 7.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Jazz Pharmaceuticals PLC                   | Jazz Pharmaceuticals PLC                                   | CUSIP: G50871105<br>LEI: 635400GAUMJCLEZRRV50 | Long             | EC               | CORP              | IE        |      2243 | NS      | $286543.25    | 0.80%             |  |  |  | No            |                  1 | On Loan: No      |
| Royalty Pharma PLC                         | Royalty Pharma PLC, Class A                                | CUSIP: G7709Q104<br>LEI: 549300FGFN7VOK8BZR03 | Long             | EC               | CORP              | GB        |     15369 | NS      | $552976.62    | 1.55%             |  |  |  | No            |                  1 | On Loan: No      |
| Tectonic Therapeutic, Inc.                 | Tectonic Therapeutic, Inc.                                 | CUSIP: 878972108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       681 | NS      | $17392.74     | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Neumora Therapeutics, Inc.                 | Neumora Therapeutics, Inc.                                 | CUSIP: 640979100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5824 | NS      | $10075.52     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Geron Corp.                                | Geron Corp.                                                | CUSIP: 374163103<br>LEI: 549300T282D7Z2YESL90 | Long             | EC               | CORP              | US        |     22923 | NS      | $32092.20     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Kiniksa Pharmaceuticals International, PLC | Kiniksa Pharmaceuticals International, PLC                 | CUSIP: G52694109<br>LEI: N/A                  | Long             | EC               | CORP              | GB        |      1523 | NS      | $51005.27     | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Allogene Therapeutics, Inc.                | Allogene Therapeutics, Inc.                                | CUSIP: 019770106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7887 | NS      | $8912.31      | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| HUTCHMED (China) Ltd.                      | HUTCHMED (China) Ltd., ADR                                 | CUSIP: 44842L103<br>LEI: 2138006X34YDQ6OBYE79 | Long             | EC               | CORP              | KY        |      1123 | NS      | $16856.23     | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Mesoblast Ltd.                             | Mesoblast Ltd., ADR                                        | CUSIP: 590717401<br>LEI: 529900J5ALF3JG921927 | Long             | EC               | CORP              | AU        |      1628 | NS      | $22515.24     | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Incyte Corp.                               | Incyte Corp.                                               | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |      7045 | NS      | $596077.45    | 1.67%             |  |  |  | No            |                  1 | On Loan: No      |
| Anavex Life Sciences Corp.                 | Anavex Life Sciences Corp.                                 | CUSIP: 032797300<br>LEI: 549300K1I5L8COCQ8W36 | Long             | EC               | CORP              | US        |      3075 | NS      | $29643.00     | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Solid Biosciences Inc.                     | Solid Biosciences Inc.                                     | CUSIP: 83422E204<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2795 | NS      | $15316.60     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Foghorn Therapeutics Inc.                  | Foghorn Therapeutics Inc.                                  | CUSIP: 344174107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2009 | NS      | $10165.54     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Centessa Pharmaceuticals PLC               | Centessa Pharmaceuticals PLC, ADR                          | CUSIP: 152309100<br>LEI: 213800GIDAARDSKOI827 | Long             | EC               | CORP              | GB        |      3451 | NS      | $57942.29     | 0.16%             |  |  |  | No            |                  1 | On Loan: —       |
| Savara Inc.                                | Savara Inc.                                                | CUSIP: 805111101<br>LEI: 5493002JO0WM3YMJXG33 | Long             | EC               | CORP              | US        |      6214 | NS      | $20381.92     | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| OmniAb, Inc.                               | OmniAb, Inc., Rts., expiring 2027-11-02                    | CUSIP: 68218J301<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       125 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| ANI Pharmaceuticals, Inc.                  | ANI Pharmaceuticals, Inc.                                  | CUSIP: 00182C103<br>LEI: 5493000T6CXTND40YH31 | Long             | EC               | CORP              | US        |       781 | NS      | $73023.50     | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| United Therapeutics Corp.                  | United Therapeutics Corp.                                  | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |      1644 | NS      | $501025.44    | 1.40%             |  |  |  | No            |                  1 | On Loan: No      |
| Avidity Biosciences, Inc.                  | Avidity Biosciences, Inc.                                  | CUSIP: 05370A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4392 | NS      | $204579.36    | 0.57%             |  |  |  | No            |                  1 | On Loan: No      |
| Iovance Biotherapeutics, Inc.              | Iovance Biotherapeutics, Inc.                              | CUSIP: 462260100<br>LEI: 2549002L8WT2ACU5Q878 | Long             | EC               | CORP              | US        |     12008 | NS      | $26777.84     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Larimar Therapeutics, Inc.                 | Larimar Therapeutics, Inc.                                 | CUSIP: 517125100<br>LEI: 529900NCBZHTTJV6HX73 | Long             | EC               | CORP              | US        |      2306 | NS      | $8347.72      | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Exelixis, Inc.                             | Exelixis, Inc.                                             | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |      9949 | NS      | $372291.58    | 1.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen Inc.                                | Biogen Inc.                                                | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |      5336 | NS      | $705525.92    | 1.97%             |  |  |  | No            |                  1 | On Loan: No      |
| Halozyme Therapeutics, Inc.                | Halozyme Therapeutics, Inc.                                | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |      4502 | NS      | $329321.30    | 0.92%             |  |  |  | No            |                  1 | On Loan: No      |
| Erasca, Inc.                               | Erasca, Inc.                                               | CUSIP: 29479A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     10190 | NS      | $15998.30     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Kura Oncology, Inc.                        | Kura Oncology, Inc.                                        | CUSIP: 50127T109<br>LEI: 5493005QORQTZCZYOP39 | Long             | EC               | CORP              | US        |      3124 | NS      | $24679.60     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Lyell Immunopharma, Inc.                   | Lyell Immunopharma, Inc.                                   | CUSIP: 55083R203<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       545 | NS      | $6038.60      | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Syndax Pharmaceuticals, Inc.               | Syndax Pharmaceuticals, Inc.                               | CUSIP: 87164F105<br>LEI: 529900OF94TRHKZVBS87 | Long             | EC               | CORP              | US        |      3103 | NS      | $50671.99     | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Castle Biosciences, Inc.                   | Castle Biosciences, Inc.                                   | CUSIP: 14843C105<br>LEI: 2549007M2Q4HLR1XD252 | Long             | EC               | CORP              | US        |      1035 | NS      | $24850.35     | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Travere Therapeutics, Inc.                 | Travere Therapeutics, Inc.                                 | CUSIP: 89422G107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3194 | NS      | $55895.00     | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Rapport Therapeutics, Inc.                 | Rapport Therapeutics, Inc.                                 | CUSIP: 75383L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1305 | NS      | $23007.15     | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| BioNTech SE                                | BioNTech SE, ADR                                           | CUSIP: 09075V102<br>LEI: 894500UZJ5LG1F8J1U58 | Long             | EC               | CORP              | DE        |      3635 | NS      | $363500.00    | 1.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Roivant Sciences Ltd.                      | Roivant Sciences Ltd.                                      | CUSIP: G76279101<br>LEI: 549300DL466NY5J6U724 | Long             | EC               | CORP              | BM        |     24820 | NS      | $296102.60    | 0.83%             |  |  |  | No            |                  1 | On Loan: —       |
| Veracyte, Inc.                             | Veracyte, Inc.                                             | CUSIP: 92337F107<br>LEI: 529900ESWZRHXOW27Z37 | Long             | EC               | CORP              | US        |      2828 | NS      | $85801.52     | 0.24%             |  |  |  | No            |                  1 | On Loan: —       |
| Krystal Biotech, Inc.                      | Krystal Biotech, Inc.                                      | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |      1054 | NS      | $155675.80    | 0.44%             |  |  |  | No            |                  1 | On Loan: No      |
| Amarin Corp. PLC                           | Amarin Corp. PLC, ADR                                      | CUSIP: 023111404<br>LEI: 5493009JFIGUFEVPK217 | Long             | EC               | CORP              | GB        |       714 | NS      | $10738.56     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Inhibrx Biosciences, Inc.                  | Inhibrx Biosciences, Inc.                                  | CUSIP: 45720N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       530 | NS      | $14946.00     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Mineralys Therapeutics, Inc.               | Mineralys Therapeutics, Inc.                               | CUSIP: 603170101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2353 | NS      | $36424.44     | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| Legend Biotech Corp.                       | Legend Biotech Corp., ADR                                  | CUSIP: 52490G102<br>LEI: 254900EIUFZTW136H859 | Long             | EC               | CORP              | KY        |      3010 | NS      | $104537.30    | 0.29%             |  |  |  | No            |                  1 | On Loan: —       |
| Rigel Pharmaceuticals, Inc.                | Rigel Pharmaceuticals, Inc.                                | CUSIP: 766559702<br>LEI: 529900KPTNUS5J8K9K66 | Long             | EC               | CORP              | US        |       648 | NS      | $25174.80     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| SIGA Technologies, Inc.                    | SIGA Technologies, Inc.                                    | CUSIP: 826917106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2567 | NS      | $21537.13     | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Scholar Rock Holding Corp.                 | Scholar Rock Holding Corp.                                 | CUSIP: 80706P103<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |      3492 | NS      | $114013.80    | 0.32%             |  |  |  | No            |                  1 | On Loan: —       |
| Theravance Biopharma Inc.                  | Theravance Biopharma Inc.                                  | CUSIP: G8807B106<br>LEI: 5493007VTSXP4Z6MIW52 | Long             | EC               | CORP              | KY        |      1795 | NS      | $24914.60     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Keros Therapeutics, Inc.                   | Keros Therapeutics, Inc.                                   | CUSIP: 492327101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1449 | NS      | $22039.29     | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| REGENXBIO Inc.                             | REGENXBIO Inc.                                             | CUSIP: 75901B107<br>LEI: 549300EOES47LATSET33 | Long             | EC               | CORP              | US        |      1801 | NS      | $16082.93     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| AbSci Corp.                                | AbSci Corp.                                                | CUSIP: 00091E109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4592 | NS      | $10974.88     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Applied Therapeutics, Inc.                 | Applied Therapeutics, Inc.                                 | CUSIP: 03828A101<br>LEI: 549300KL3IJPHZM2GR04 | Long             | EC               | CORP              | US        |      5103 | NS      | $2514.25      | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Ocular Therapeutix, Inc.                   | Ocular Therapeutix, Inc.                                   | CUSIP: 67576A100<br>LEI: 529900ABAWFXOHSIHG03 | Long             | EC               | CORP              | US        |      5748 | NS      | $70183.08     | 0.20%             |  |  |  | No            |                  1 | On Loan: —       |
| KalVista Pharmaceuticals, Inc.             | KalVista Pharmaceuticals, Inc.                             | CUSIP: 483497103<br>LEI: 529900Q7IDA3WUGRZA51 | Long             | EC               | CORP              | US        |      1783 | NS      | $23999.18     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| IDEAYA Biosciences, Inc.                   | IDEAYA Biosciences, Inc.                                   | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |      3228 | NS      | $79247.40     | 0.22%             |  |  |  | No            |                  1 | On Loan: —       |
| Autolus Therapeutics PLC                   | Autolus Therapeutics PLC, ADR                              | CUSIP: 05280R100<br>LEI: 549300C0KZP8EYROLL02 | Long             | EC               | CORP              | GB        |      7222 | NS      | $10833.00     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Alpha Teknova, Inc.                        | Alpha Teknova, Inc.                                        | CUSIP: 02080L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1911 | NS      | $8255.52      | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| PepGen Inc.                                | PepGen Inc.                                                | CUSIP: 713317105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1171 | NS      | $1358.36      | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| Novavax, Inc.                              | Novavax, Inc.                                              | CUSIP: 670002401<br>LEI: 529900J4GJHPEPQ23205 | Long             | EC               | CORP              | US        |      5833 | NS      | $43572.51     | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| NewAmsterdam Pharma Co. N.V.               | NewAmsterdam Pharma Co. N.V.                               | CUSIP: N62509109<br>LEI: 984500B6549TF6E14D36 | Long             | EC               | CORP              | NL        |      4089 | NS      | $98340.45     | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| Cartesian Therapeutics, Inc.               | Cartesian Therapeutics, Inc.                               | CUSIP: 816212302<br>LEI: 529900NMN0LACZOL7C43 | Long             | EC               | CORP              | US        |       937 | NS      | $9416.85      | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Ascendis Pharma A/S                        | Ascendis Pharma A/S, ADR                                   | CUSIP: 04351P101<br>LEI: 549300B66JN3W3J8GH73 | Long             | EC               | CORP              | DK        |      2213 | NS      | $429919.51    | 1.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Astria Therapeutics, Inc.                  | Astria Therapeutics, Inc.                                  | CUSIP: 04635X102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2038 | NS      | $12594.84     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Pacific Biosciences of California, Inc.    | Pacific Biosciences of California, Inc.                    | CUSIP: 69404D108<br>LEI: 529900F1BWRE1M0KZN89 | Long             | EC               | CORP              | US        |     10793 | NS      | $14138.83     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Agios Pharmaceuticals, Inc.                | Agios Pharmaceuticals, Inc.                                | CUSIP: 00847X104<br>LEI: 529900ONJHY8EOGYT555 | Long             | EC               | CORP              | US        |      2137 | NS      | $80586.27     | 0.23%             |  |  |  | No            |                  1 | On Loan: —       |
| Revolution Medicines, Inc.                 | Revolution Medicines, Inc.                                 | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |      6796 | NS      | $258044.12    | 0.72%             |  |  |  | No            |                  1 | On Loan: —       |
| Aurinia Pharmaceuticals Inc.               | Aurinia Pharmaceuticals Inc.                               | CUSIP: 05156V102<br>LEI: 5299008YP2BW4570ML28 | Long             | EC               | CORP              | CA        |      4859 | NS      | $58259.41     | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Denali Therapeutics Inc.                   | Denali Therapeutics Inc.                                   | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |      5233 | NS      | $79907.91     | 0.22%             |  |  |  | No            |                  1 | On Loan: —       |
| Nkarta, Inc.                               | Nkarta, Inc.                                               | CUSIP: 65487U108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2547 | NS      | $5399.64      | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Replimune Group, Inc.                      | Replimune Group, Inc.                                      | CUSIP: 76029N106<br>LEI: 549300AY704NEIRC4K64 | Long             | EC               | CORP              | US        |      2778 | NS      | $15001.20     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Sana Biotechnology, Inc.                   | Sana Biotechnology, Inc.                                   | CUSIP: 799566104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8121 | NS      | $24850.26     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Maravai LifeSciences Holdings, Inc.        | Maravai LifeSciences Holdings, Inc., Class A               | CUSIP: 56600D107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5180 | NS      | $12535.60     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Moderna, Inc.                              | Moderna, Inc.                                              | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |     14111 | NS      | $339933.99    | 0.95%             |  |  |  | No            |                  1 | On Loan: —       |
| NovoCure Ltd.                              | NovoCure Ltd.                                              | CUSIP: G6674U108<br>LEI: 213800YPP55UMHWA4826 | Long             | EC               | CORP              | JE        |      4018 | NS      | $49541.94     | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| Crinetics Pharmaceuticals, Inc.            | Crinetics Pharmaceuticals, Inc.                            | CUSIP: 22663K107<br>LEI: 549300Q1CNFXK5P31D28 | Long             | EC               | CORP              | US        |      3411 | NS      | $105706.89    | 0.30%             |  |  |  | No            |                  1 | On Loan: —       |
| OmniAb, Inc.                               | OmniAb, Inc., Rts., 2027-11-02                             | CUSIP: 68218J202<br>LEI: 5493008K7TB0IKP37H79 | Long             | EC               | CORP              | US        |       125 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  3 | On Loan: —       |
| Vaxcyte, Inc.                              | Vaxcyte, Inc.                                              | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |      4731 | NS      | $145667.49    | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Silence Therapeutics PLC                   | Silence Therapeutics PLC, ADR                              | CUSIP: 82686Q101<br>LEI: 213800SSURRJBX85SQ91 | Long             | EC               | CORP              | GB        |      1694 | NS      | $8148.14      | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Janux Therapeutics, Inc.                   | Janux Therapeutics, Inc.                                   | CUSIP: 47103J105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2128 | NS      | $48348.16     | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| Sarepta Therapeutics, Inc.                 | Sarepta Therapeutics, Inc.                                 | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |      3540 | NS      | $64428.00     | 0.18%             |  |  |  | No            |                  1 | On Loan: —       |
| Structure Therapeutics Inc.                | Structure Therapeutics Inc., ADR                           | CUSIP: 86366E106<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |      2145 | NS      | $41398.50     | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Amicus Therapeutics, Inc.                  | Amicus Therapeutics, Inc.                                  | CUSIP: 03152W109<br>LEI: 549300MRD1SMUTNBPQ53 | Long             | EC               | CORP              | US        |     11097 | NS      | $84226.23     | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurogene Inc.                             | Neurogene Inc.                                             | CUSIP: 64135M105<br>LEI: 529900A7VIY892SZVW73 | Long             | EC               | CORP              | US        |       521 | NS      | $9628.08      | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| EyePoint Pharmaceuticals, Inc.             | EyePoint Pharmaceuticals, Inc.                             | CUSIP: 30233G209<br>LEI: 549300QE1RU34T50MR69 | Long             | EC               | CORP              | US        |      2481 | NS      | $28705.17     | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Sanofi                                     | Sanofi, ADR                                                | CUSIP: 80105N105<br>LEI: 549300E9PC51EN656011 | Long             | EC               | CORP              | FR        |     10264 | NS      | $507862.72    | 1.42%             |  |  |  | No            |                  1 | On Loan: —       |
| Arcutis Biotherapeutics, Inc.              | Arcutis Biotherapeutics, Inc.                              | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4292 | NS      | $66611.84     | 0.19%             |  |  |  | No            |                  1 | On Loan: —       |
| Q32 Bio Inc.                               | Q32 Bio Inc.                                               | CUSIP: 746964105<br>LEI: 549300RWKPJEFTM3K452 | Long             | EC               | CORP              | US        |       436 | NS      | $745.56       | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| Invesco Private Prime Fund                 | Invesco Private Prime Fund                                 | CUSIP: N/A<br>LEI: N/A                        | Long             | STIV             | PF                | US        |   4966542 | NS      | $4966541.52   | 13.88%            |  |  |  | No            |                  2 | On Loan: No      |
| 89bio, Inc.                                | 89bio, Inc.                                                | CUSIP: 282559103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5263 | NS      | $47524.89     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Pacira Biosciences, Inc.                   | Pacira Biosciences, Inc.                                   | CUSIP: 695127100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1664 | NS      | $44378.88     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Trevi Therapeutics, Inc.                   | Trevi Therapeutics, Inc.                                   | CUSIP: 89532M101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3661 | NS      | $26560.56     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Third Harmonic Bio, Inc.                   | Third Harmonic Bio, Inc., Class B                          | CUSIP: 88427A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1605 | NS      | $48.15        | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| PTC Therapeutics, Inc.                     | PTC Therapeutics, Inc.                                     | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |      2902 | NS      | $143155.66    | 0.40%             |  |  |  | No            |                  1 | On Loan: —       |
| Amgen Inc.                                 | Amgen Inc.                                                 | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |      8741 | NS      | $2514873.11   | 7.03%             |  |  |  | No            |                  1 | On Loan: No      |
| AC Immune S.A.                             | AC Immune S.A.                                             | CUSIP: H00263105<br>LEI: 967600VLQ0ZC2HSOG765 | Long             | EC               | CORP              | CH        |      3606 | NS      | $7356.24      | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Mind Medicine (MindMed) Inc.               | Mind Medicine (MindMed) Inc.                               | CUSIP: 60255C885<br>LEI: 549300QY8KN1O6RPFJ13 | Long             | EC               | CORP              | CA        |      2715 | NS      | $24109.20     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Day One Biopharmaceuticals, Inc.           | Day One Biopharmaceuticals, Inc.                           | CUSIP: 23954D109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3645 | NS      | $27373.95     | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Oruka Therapeutics, Inc.                   | Oruka Therapeutics, Inc.                                   | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |      1344 | NS      | $19891.20     | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Climb Bio, Inc.                            | Climb Bio, Inc.                                            | CUSIP: 28658R106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2430 | NS      | $5418.90      | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Cartesian Therapeutics, Inc.               | Cartesian Therapeutics, Inc., Rts., 2050-12-31             | CUSIP: 816212112<br>LEI: 529900NMN0LACZOL7C43 | Long             | EC               | CORP              | US        |      2633 | NS      | $359.22       | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| uniQure N.V.                               | uniQure N.V.                                               | CUSIP: N90064101<br>LEI: 724500RPCTZLFYJZ3S98 | Long             | EC               | CORP              | NL        |      1968 | NS      | $32137.44     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Acrivon Therapeutics, Inc.                 | Acrivon Therapeutics, Inc.                                 | CUSIP: 004890109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1137 | NS      | $1523.58      | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Tyra Biosciences, Inc.                     | Tyra Biosciences, Inc.                                     | CUSIP: 90240B106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1900 | NS      | $24073.00     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Lexicon Pharmaceuticals, Inc.              | Lexicon Pharmaceuticals, Inc.                              | CUSIP: 528872302<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     13086 | NS      | $14394.60     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| ADMA Biologics, Inc.                       | ADMA Biologics, Inc.                                       | CUSIP: 000899104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8762 | NS      | $151232.12    | 0.42%             |  |  |  | No            |                  1 | On Loan: No      |
| Biomea Fusion, Inc.                        | Biomea Fusion, Inc.                                        | CUSIP: 09077A106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1349 | NS      | $2630.55      | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| BridgeBio Pharma, Inc.                     | BridgeBio Pharma, Inc.                                     | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |      6925 | NS      | $358438.00    | 1.00%             |  |  |  | No            |                  1 | On Loan: —       |
| Annexon, Inc.                              | Annexon, Inc.                                              | CUSIP: 03589W102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3945 | NS      | $8126.70      | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Artiva Biotherapeutics, Inc.               | Artiva Biotherapeutics, Inc.                               | CUSIP: 04317A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       871 | NS      | $2743.65      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Lexeo Therapeutics, Inc.                   | Lexeo Therapeutics, Inc.                                   | CUSIP: 52886X107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1191 | NS      | $5704.89      | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcellx, Inc.                              | Arcellx, Inc.                                              | CUSIP: 03940C100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2022 | NS      | $140306.58    | 0.39%             |  |  |  | No            |                  1 | On Loan: No      |
| CureVac N.V.                               | CureVac N.V.                                               | CUSIP: N2451R105<br>LEI: 724500BUT8GAG9LMYN56 | Long             | EC               | CORP              | NL        |      8104 | NS      | $43518.48     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Arbutus Biopharma Corp.                    | Arbutus Biopharma Corp.                                    | CUSIP: 03879J100<br>LEI: 25490064CESONAUIAS23 | Long             | EC               | CORP              | CA        |      6896 | NS      | $25584.16     | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Tango Therapeutics Inc.                    | Tango Therapeutics Inc.                                    | CUSIP: 87583X109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3888 | NS      | $26088.48     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Grifols, S.A.                              | Grifols, S.A., ADR                                         | CUSIP: 398438408<br>LEI: 959800HSSNXWRKBK4N60 | Long             | EC               | CORP              | ES        |      4385 | NS      | $43718.45     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| GRAIL, Inc.                                | GRAIL, Inc.                                                | CUSIP: 384747101<br>LEI: 2549009XSNESW3VE8024 | Long             | EC               | CORP              | US        |      1308 | NS      | $42889.32     | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Ionis Pharmaceuticals, Inc.                | Ionis Pharmaceuticals, Inc.                                | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |      5791 | NS      | $246899.29    | 0.69%             |  |  |  | No            |                  1 | On Loan: —       |
| Amylyx Pharmaceuticals, Inc.               | Amylyx Pharmaceuticals, Inc.                               | CUSIP: 03237H101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3208 | NS      | $30091.04     | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| BeOne Medicines Ltd.                       | BeOne Medicines Ltd., ADR                                  | CUSIP: 07725L102<br>LEI: 549300JFUK6FRD5MH739 | Long             | EC               | CORP              | CH        |      1504 | NS      | $460299.20    | 1.29%             |  |  |  | No            |                  1 | On Loan: —       |
| Recursion Pharmaceuticals, Inc.            | Recursion Pharmaceuticals, Inc., Class A                   | CUSIP: 75629V104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     14563 | NS      | $68446.10     | 0.19%             |  |  |  | No            |                  1 | On Loan: —       |
| ARS Pharmaceuticals, Inc.                  | ARS Pharmaceuticals, Inc.                                  | CUSIP: 82835W108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3538 | NS      | $41111.56     | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| Illumina, Inc.                             | Illumina, Inc.                                             | CUSIP: 452327109<br>LEI: SQ95QG8SR5Q56LSNF682 | Long             | EC               | CORP              | US        |      5777 | NS      | $577468.92    | 1.61%             |  |  |  | No            |                  1 | On Loan: No      |
| Phibro Animal Health Corp.                 | Phibro Animal Health Corp., Class A                        | CUSIP: 71742Q106<br>LEI: 549300U24SP4AF2JUX52 | Long             | EC               | CORP              | US        |       729 | NS      | $27024.03     | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Vericel Corp.                              | Vericel Corp.                                              | CUSIP: 92346J108<br>LEI: 54930076YM3PLTDR4B91 | Long             | EC               | CORP              | US        |      1835 | NS      | $66720.60     | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Avadel Pharmaceuticals PLC                 | Avadel Pharmaceuticals PLC                                 | CUSIP: G29687103<br>LEI: 549300E27PTSG2RHC762 | Long             | EC               | CORP              | IE        |      3477 | NS      | $51320.52     | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| Guardant Health, Inc.                      | Guardant Health, Inc.                                      | CUSIP: 40131M109<br>LEI: 254900M8C3E5VC8BR186 | Long             | EC               | CORP              | US        |      4534 | NS      | $305682.28    | 0.85%             |  |  |  | No            |                  1 | On Loan: No      |
| Innoviva, Inc.                             | Innoviva, Inc.                                             | CUSIP: 45781M101<br>LEI: 549300ACOX4QTBES6535 | Long             | EC               | CORP              | US        |      2255 | NS      | $46069.65     | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| MannKind Corp.                             | MannKind Corp.                                             | CUSIP: 56400P706<br>LEI: 213800GFBCNY1ZFST722 | Long             | EC               | CORP              | US        |     10927 | NS      | $50154.93     | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Indivior PLC                               | Indivior PLC                                               | CUSIP: G4766E116<br>LEI: 213800V3NCQTY7IED471 | Long             | EC               | CORP              | GB        |      4540 | NS      | $110231.20    | 0.31%             |  |  |  | No            |                  1 | On Loan: No      |
| Altimmune, Inc.                            | Altimmune, Inc.                                            | CUSIP: 02155H200<br>LEI: 549300EOYCQ8SW3NVE64 | Long             | EC               | CORP              | US        |      2921 | NS      | $11187.43     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Apogee Therapeutics, Inc.                  | Apogee Therapeutics, Inc.                                  | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1654 | NS      | $60155.98     | 0.17%             |  |  |  | No            |                  1 | On Loan: —       |
| BioCryst Pharmaceuticals, Inc.             | BioCryst Pharmaceuticals, Inc.                             | CUSIP: 09058V103<br>LEI: 549300Z0INP1Z5NP6J59 | Long             | EC               | CORP              | US        |      7537 | NS      | $62632.47     | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| AnaptysBio, Inc.                           | AnaptysBio, Inc.                                           | CUSIP: 032724106<br>LEI: 529900HH4WQT03IG1A12 | Long             | EC               | CORP              | US        |      1056 | NS      | $21468.48     | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Intellia Therapeutics, Inc.                | Intellia Therapeutics, Inc.                                | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |      3737 | NS      | $42433.64     | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Harmony Biosciences Holdings, Inc.         | Harmony Biosciences Holdings, Inc.                         | CUSIP: 413197104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2122 | NS      | $78280.58     | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Viatris Inc.                               | Viatris Inc.                                               | CUSIP: 92556V106<br>LEI: 254900ZZTSW7NL773X71 | Long             | EC               | CORP              | US        |     42818 | NS      | $451729.90    | 1.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Twist Bioscience Corp.                     | Twist Bioscience Corp.                                     | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |      2159 | NS      | $58228.23     | 0.16%             |  |  |  | No            |                  1 | On Loan: —       |
| Pyxis Oncology, Inc.                       | Pyxis Oncology, Inc.                                       | CUSIP: 747324101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2221 | NS      | $2842.88      | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Rhythm Pharmaceuticals, Inc.               | Rhythm Pharmaceuticals, Inc.                               | CUSIP: 76243J105<br>LEI: 529900JPNWXQ8DPLA551 | Long             | EC               | CORP              | US        |      2327 | NS      | $240030.05    | 0.67%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytokinetics, Inc.                         | Cytokinetics, Inc.                                         | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |      4377 | NS      | $154639.41    | 0.43%             |  |  |  | No            |                  1 | On Loan: —       |
| Alvotech                                   | Alvotech                                                   | CUSIP: L01800108<br>LEI: 222100DCZBOWV5DZ8372 | Long             | EC               | CORP              | LU        |      9711 | NS      | $78367.77     | 0.22%             |  |  |  | No            |                  1 | On Loan: —       |
| Corvus Pharmaceuticals, Inc.               | Corvus Pharmaceuticals, Inc.                               | CUSIP: 221015100<br>LEI: 549300I3AVJ8F75NCX65 | Long             | EC               | CORP              | US        |      2779 | NS      | $15951.46     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Arrowhead Pharmaceuticals, Inc.            | Arrowhead Pharmaceuticals, Inc.                            | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |      5034 | NS      | $110899.02    | 0.31%             |  |  |  | No            |                  1 | On Loan: —       |
| Evolus, Inc.                               | Evolus, Inc.                                               | CUSIP: 30052C107<br>LEI: 549300VYQRYBQOT8V419 | Long             | EC               | CORP              | US        |      2325 | NS      | $17739.75     | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Invesco Government & Agency Portfolio      | Invesco Government & Agency Portfolio, Institutional Class | CUSIP: 825252885<br>LEI: 5493007T1J7WZ5QI1A47 | Long             | STIV             | RF                | US        |     18857 | NS      | $18856.59     | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Xenon Pharmaceuticals Inc.                 | Xenon Pharmaceuticals Inc.                                 | CUSIP: 98420N105<br>LEI: 549300XV44Q9Z1MIPQ03 | Long             | EC               | CORP              | CA        |      2790 | NS      | $108000.90    | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Wave Life Sciences Ltd.                    | Wave Life Sciences Ltd.                                    | CUSIP: Y95308105<br>LEI: 54930070006GPKFYZ813 | Long             | EC               | CORP              | SG        |      5554 | NS      | $53318.40     | 0.15%             |  |  |  | No            |                  1 | On Loan: —       |
| Prime Medicine, Inc.                       | Prime Medicine, Inc.                                       | CUSIP: 74168J101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4724 | NS      | $15305.76     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Medpace Holdings, Inc.                     | Medpace Holdings, Inc.                                     | CUSIP: 58506Q109<br>LEI: 549300H8TYEUVTW14A54 | Long             | EC               | CORP              | US        |      1046 | NS      | $497383.46    | 1.39%             |  |  |  | No            |                  1 | On Loan: No      |
| TScan Therapeutics, Inc.                   | TScan Therapeutics, Inc.                                   | CUSIP: 89854M101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1890 | NS      | $3402.00      | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Zai Lab Ltd.                               | Zai Lab Ltd., ADR                                          | CUSIP: 98887Q104<br>LEI: 549300P2UYQ9U5LY1T58 | Long             | EC               | CORP              | KY        |      2130 | NS      | $70503.00     | 0.20%             |  |  |  | No            |                  1 | On Loan: —       |
| Codexis, Inc.                              | Codexis, Inc.                                              | CUSIP: 192005106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2996 | NS      | $8179.08      | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Ultragenyx Pharmaceutical Inc.             | Ultragenyx Pharmaceutical Inc.                             | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |      3442 | NS      | $103122.32    | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| MeiraGTx Holdings PLC                      | MeiraGTx Holdings PLC                                      | CUSIP: G59665102<br>LEI: 54930007YV6NYIOGFZ57 | Long             | EC               | CORP              | KY        |      2891 | NS      | $21104.30     | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Supernus Pharmaceuticals, Inc.             | Supernus Pharmaceuticals, Inc.                             | CUSIP: 868459108<br>LEI: 549300GRM36VBKISYJ58 | Long             | EC               | CORP              | US        |      2019 | NS      | $91097.28     | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Invesco Private Government Fund            | Invesco Private Government Fund                            | CUSIP: N/A<br>LEI: N/A                        | Long             | STIV             | PF                | US        |   1910357 | NS      | $1910357.30   | 5.34%             |  |  |  | No            |                  2 | On Loan: No      |
| Cogent Biosciences, Inc.                   | Cogent Biosciences, Inc.                                   | CUSIP: 19240Q201<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4094 | NS      | $49455.52     | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| 4D Molecular Therapeutics, Inc.            | 4D Molecular Therapeutics, Inc.                            | CUSIP: 35104E100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1665 | NS      | $10256.40     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Tarsus Pharmaceuticals, Inc.               | Tarsus Pharmaceuticals, Inc.                               | CUSIP: 87650L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1528 | NS      | $89510.24     | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Immunocore Holdings PLC                    | Immunocore Holdings PLC, ADR                               | CUSIP: 45258D105<br>LEI: 213800IUE3DFS84BVN18 | Long             | EC               | CORP              | GB        |      1438 | NS      | $46332.36     | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Sutro Biopharma, Inc.                      | Sutro Biopharma, Inc.                                      | CUSIP: 869367102<br>LEI: 5493005U6P15VD25P851 | Long             | EC               | CORP              | US        |      3037 | NS      | $2603.01      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Genmab A/S                                 | Genmab A/S, ADR                                            | CUSIP: 372303206<br>LEI: 529900MTJPDPE4MHJ122 | Long             | EC               | CORP              | DK        |      1506 | NS      | $37454.22     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Verona Pharma PLC                          | Verona Pharma PLC, ADR                                     | CUSIP: 925050106<br>LEI: 213800EVI6O6J3TIAL06 | Long             | EC               | CORP              | GB        |      2862 | NS      | $303114.42    | 0.85%             |  |  |  | No            |                  1 | On Loan: No      |
| Galapagos N.V.                             | Galapagos N.V., ADR                                        | CUSIP: 36315X101<br>LEI: 549300QKJ78IY0IOV655 | Long             | EC               | CORP              | BE        |       547 | NS      | $17197.68     | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| AbCellera Biologics Inc.                   | AbCellera Biologics Inc.                                   | CUSIP: 00288U106<br>LEI: 9845000861BC95FF9F73 | Long             | EC               | CORP              | CA        |     10749 | NS      | $44930.82     | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Edgewise Therapeutics, Inc.                | Edgewise Therapeutics, Inc.                                | CUSIP: 28036F105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3779 | NS      | $54228.65     | 0.15%             |  |  |  | No            |                  1 | On Loan: —       |
| Taysha Gene Therapies Inc.                 | Taysha Gene Therapies Inc.                                 | CUSIP: 877619106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      9401 | NS      | $27450.92     | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Zymeworks Inc.                             | Zymeworks Inc.                                             | CUSIP: 98985Y108<br>LEI: 894500AHOYAGYLYZJL67 | Long             | EC               | CORP              | US        |      2517 | NS      | $37276.77     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Enliven Therapeutics, Inc.                 | Enliven Therapeutics, Inc.                                 | CUSIP: 29337E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1753 | NS      | $35533.31     | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| Tevogen Bio Holdings Inc.                  | Tevogen Bio Holdings Inc.                                  | CUSIP: 88165K101<br>LEI: 549300AC21G4NBK9D322 | Long             | EC               | CORP              | US        |      6625 | NS      | $6028.75      | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Protagonist Therapeutics, Inc.             | Protagonist Therapeutics, Inc.                             | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2267 | NS      | $133866.35    | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Amneal Pharmaceuticals, Inc.               | Amneal Pharmaceuticals, Inc.                               | CUSIP: 03168L105<br>LEI: 549300VV176ZO5WQHZ61 | Long             | EC               | CORP              | US        |     11382 | NS      | $108811.92    | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Pliant Therapeutics, Inc.                  | Pliant Therapeutics, Inc.                                  | CUSIP: 729139105<br>LEI: 5493002Q5LITR7VHZH02 | Long             | EC               | CORP              | US        |      2222 | NS      | $3644.08      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Editas Medicine, Inc.                      | Editas Medicine, Inc.                                      | CUSIP: 28106W103<br>LEI: 5299000AON4Q9NT2JE42 | Long             | EC               | CORP              | US        |      3007 | NS      | $7727.99      | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Precigen, Inc.                             | Precigen, Inc.                                             | CUSIP: 74017N105<br>LEI: 549300XCWNQU35K64G19 | Long             | EC               | CORP              | US        |     10638 | NS      | $47977.38     | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Alumis Inc.                                | Alumis Inc.                                                | CUSIP: 022307102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3454 | NS      | $16026.56     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Terns Pharmaceuticals, Inc.                | Terns Pharmaceuticals, Inc.                                | CUSIP: 880881107<br>LEI: 254900S1ZDQMF4MYP709 | Long             | EC               | CORP              | US        |      3131 | NS      | $21791.76     | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Nurix Therapeutics, Inc.                   | Nurix Therapeutics, Inc.                                   | CUSIP: 67080M103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2743 | NS      | $25619.62     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Summit Therapeutics Inc.                   | Summit Therapeutics Inc.                                   | CUSIP: 86627T108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     27076 | NS      | $641701.20    | 1.79%             |  |  |  | No            |                  1 | On Loan: —       |
| Spyre Therapeutics, Inc.                   | Spyre Therapeutics, Inc.                                   | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |      2177 | NS      | $35898.73     | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| MaxCyte, Inc.                              | MaxCyte, Inc.                                              | CUSIP: 57777K106<br>LEI: 54930053YHXULRFCU991 | Long             | EC               | CORP              | US        |      3827 | NS      | $5319.53      | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| argenx SE                                  | argenx SE, ADR                                             | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |      1148 | NS      | $817605.60    | 2.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Monte Rosa Therapeutics, Inc.              | Monte Rosa Therapeutics, Inc.                              | CUSIP: 61225M102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2228 | NS      | $10694.40     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| ArriVent Biopharma, Inc.                   | ArriVent Biopharma, Inc.                                   | CUSIP: 04272N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1233 | NS      | $23574.96     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| CG Oncology, Inc.                          | CG Oncology, Inc.                                          | CUSIP: 156944100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2780 | NS      | $74559.60     | 0.21%             |  |  |  | No            |                  1 | On Loan: —       |
| ORIC Pharmaceuticals, Inc.                 | ORIC Pharmaceuticals, Inc.                                 | CUSIP: 68622P109<br>LEI: 54930033FJRNEYBW0L25 | Long             | EC               | CORP              | US        |      2553 | NS      | $26117.19     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Kymera Therapeutics, Inc.                  | Kymera Therapeutics, Inc.                                  | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2373 | NS      | $97767.60     | 0.27%             |  |  |  | No            |                  1 | On Loan: —       |
| CRISPR Therapeutics AG                     | CRISPR Therapeutics AG                                     | CUSIP: H17182108<br>LEI: 506700O6IRRIQLT3W370 | Long             | EC               | CORP              | CH        |      3169 | NS      | $164249.27    | 0.46%             |  |  |  | No            |                  1 | On Loan: No      |
| Alkermes PLC                               | Alkermes PLC                                               | CUSIP: G01767105<br>LEI: 549300YHRMYLL071E243 | Long             | EC               | CORP              | IE        |      6029 | NS      | $174660.13    | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Merus N.V.                                 | Merus N.V.                                                 | CUSIP: N5749R100<br>LEI: 549300W8GPUWU8QNU293 | Long             | EC               | CORP              | NL        |      2518 | NS      | $165785.12    | 0.46%             |  |  |  | No            |                  1 | On Loan: No      |
| Vanda Pharmaceuticals Inc.                 | Vanda Pharmaceuticals Inc.                                 | CUSIP: 921659108<br>LEI: 529900AY8VOOQBKJ0O70 | Long             | EC               | CORP              | US        |      2118 | NS      | $10018.14     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Stoke Therapeutics, Inc.                   | Stoke Therapeutics, Inc.                                   | CUSIP: 86150R107<br>LEI: 549300RD25SS2DIJHJ67 | Long             | EC               | CORP              | US        |      1962 | NS      | $38769.12     | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| Voyager Therapeutics, Inc.                 | Voyager Therapeutics, Inc.                                 | CUSIP: 92915B106<br>LEI: 54930082S4XVR0ZWCC74 | Long             | EC               | CORP              | US        |      1992 | NS      | $6693.12      | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| scPharmaceuticals Inc.                     | scPharmaceuticals Inc.                                     | CUSIP: 810648105<br>LEI: 549300F55SN4ZR2OA180 | Long             | EC               | CORP              | US        |      1910 | NS      | $10505.00     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Akero Therapeutics, Inc.                   | Akero Therapeutics, Inc.                                   | CUSIP: 00973Y108<br>LEI: 549300SI3KG74LBE2955 | Long             | EC               | CORP              | US        |      2913 | NS      | $136124.49    | 0.38%             |  |  |  | No            |                  1 | On Loan: —       |
| Alnylam Pharmaceuticals, Inc.              | Alnylam Pharmaceuticals, Inc.                              | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |      4136 | NS      | $1846765.36   | 5.16%             |  |  |  | No            |                  1 | On Loan: No      |
| UroGen Pharma Ltd.                         | UroGen Pharma Ltd.                                         | CUSIP: M96088105<br>LEI: 549300C0YCX7CG2G5D50 | Long             | EC               | CORP              | IL        |      1656 | NS      | $32209.20     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Relay Therapeutics, Inc.                   | Relay Therapeutics, Inc.                                   | CUSIP: 75943R102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6179 | NS      | $22182.61     | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Aquestive Therapeutics, Inc.               | Aquestive Therapeutics, Inc.                               | CUSIP: 03843E104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3584 | NS      | $13511.68     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Madrigal Pharmaceuticals, Inc.             | Madrigal Pharmaceuticals, Inc.                             | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |       811 | NS      | $355096.35    | 0.99%             |  |  |  | No            |                  1 | On Loan: No      |
| Fate Therapeutics, Inc.                    | Fate Therapeutics, Inc.                                    | CUSIP: 31189P102<br>LEI: 549300L14Q4UHOODLA90 | Long             | EC               | CORP              | US        |      4126 | NS      | $4291.04      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| OmniAb, Inc.                               | OmniAb, Inc.                                               | CUSIP: 68218J103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4399 | NS      | $7038.40      | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Dyne Therapeutics, Inc.                    | Dyne Therapeutics, Inc.                                    | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4086 | NS      | $55120.14     | 0.15%             |  |  |  | No            |                  1 | On Loan: —       |

### Signature

**Date Signed:** 2025-09-30

**Name of Applicant:** Invesco Exchange-Traded Fund Trust II

**Signature:** Adrien Deberghes

**Name of Signer:** Adrien Deberghes

**Title:** Vice President