# EDGAR Filing Document

**Accession Number:** 0001501756
**File Stem:** 0001193125-25-312800
**Filing Date:** 2025-12
**Character Count:** 17427
**Document Hash:** 7cae5b1aaf032b7c500f357224c224eb
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-25-312800.hdr.sgml**: 20251209

**ACCESSION NUMBER**: 0001193125-25-312800

**CONFORMED SUBMISSION TYPE**: S-8 POS

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20251209

**DATE AS OF CHANGE**: 20251209

**EFFECTIVENESS DATE**: 20251209

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Adverum Biotechnologies, Inc.
- **CENTRAL INDEX KEY:** 0001501756
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 205258327
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8 POS
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-199296
- **FILM NUMBER:** 251559426

**BUSINESS ADDRESS:**
- **STREET 1:** 100 CARDINAL WAY
- **CITY:** REDWOOD CITY
- **STATE:** CA
- **ZIP:** 94063
- **BUSINESS PHONE:** (650) 649-1004

**MAIL ADDRESS:**
- **STREET 1:** 100 CARDINAL WAY
- **CITY:** REDWOOD CITY
- **STATE:** CA
- **ZIP:** 94063

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Avalanche Biotechnologies, Inc.
- **DATE OF NAME CHANGE:** 20100921

**As filed with the Securities and Exchange Commission on December 9, 2025** 

**Registration No. 333-199296** 

**Registration No. 333-203398** 

**Registration No. 333-211439** 

**Registration No. 333-218465** 

**Registration No. 333-220894** 

**Registration No. 333-223894** 

**Registration No. 333-230138** 

**Registration No. 333-233135** 

**Registration No. 333-237136** 

**Registration No. 333-243761** 

**Registration No. 333-253727** 

**Registration No. 333-263954** 

**Registration No. 333-266794** 

**Registration No. 333-271001** 

**Registration No. 333-278046** 

**Registration No. 333-280567** 

**Registration No. 333-283935** 

**Registration No. 333-285358** 

**Registration No. 333-288187** 

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**Washington, D.C. 20549** 

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-199296** 

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-203398** 

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-211439** 

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-218465** 

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-220894** 

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-223894** 

**POST-EFFECTIVE AMENDMENT NO. 2 TO FORM S-8 REGISTRATION STATEMENT NO. 333-230138** 

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-233135** 

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-237136** 

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-243761** 

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-253727** 

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-263954** 

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-266794** 

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-271001** 

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-278046** 

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-280567** 

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-283935** 

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-285358** 

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-288187** 

**FORM S-8**

**REGISTRATION STATEMENT** 

***UNDER***

***THE SECURITIES ACT OF 1933***

## Adverum Biotechnologies, Inc.
**(Exact name of registrant as specified in its charter)** 

---

| | |
|:---|:---|
| **Delaware** | **20-5258327** |
| **(State or other jurisdiction of<br>incorporation or organization)** | **(IRS employer**<br> **identification number)** |
| **100 Cardinal Way**<br> **Redwood City, California 94063** | **94063** |
| **(Address of Principal Executive Offices)** | **(Zip Code)** |

---

**Amended and Restated 2006 Equity Incentive Plan, as amended** 

**2014 Equity Incentive Award Plan, as amended and restated** 

**2014 Employee Stock Purchase Plan, as amended and restated** 

**2017 Inducement Plan, as amended and restated** 

**2024 Equity Incentive Award Plan, as amended and restated** 

**(Full title of the Plans)** 

**Jonathan R. Haug** 

**President** 

**Adverum Biotechnologies, Inc.** 

**Lilly Corporate Center** 

**Indianapolis, Indiana 46285** 

**(Name and address of agent for service)** 

**(317) 276-2000** 

**(Telephone number, including area code, of agent for service)** 

**Copy to:** 

**Emily Oldshue** 

**Ropes & Gray LLP** 

**Prudential Tower, 800 Boylston Street** 

**Boston, Massachusetts 02199** 

**(617) 951-7000** 

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See definitions of "large accelerated filer, "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☐ | Accelerated filer | ☐ |
| Non-accelerated filer | ☒ | Smaller reporting company | ☒ |
|  |  | Emerging growth company | ☐ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

------

**DEREGISTRATION OF SECURITIES** 

These Post-Effective Amendments (these "Post-Effective Amendments") are being filed by Adverum Biotechnologies, Inc. (the "Registrant") to deregister all shares of the Registrant's common stock, par value $0.0001 per share (the "Shares"), that remain unissued under the following Registration Statements on Form S-8 (each, a "Registration Statement", and collectively, the "Registration Statements") previously filed by the Registrant with the U.S. Securities and Exchange Commission (the "SEC"):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration Statement No. [333-199296](http://www.sec.gov/Archives/edgar/data/1501756/000119312514371003/d803086ds8.htm) pertaining to the registration of (i) an aggregate of 5,077,600 Shares issuable under the
Registrant's Amended and Restated 2006 Equity Incentive Plan, as amended, (ii) an aggregate of 2,394,732 Shares issuable under the Registrant's 2014 Equity Incentive Award Plan, as amended and restated (the "2014 Plan")
and (iii) an aggregate of 208,833 Shares under the Registrant's 2014 Employee Stock Purchase Plan, as amended and restated (the "2014 ESPP"), which was filed with the SEC on October 14, 2014.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration Statement No. [333-203398](http://www.sec.gov/Archives/edgar/data/1501756/000119312515128949/d884936ds8.htm) pertaining to the registration of an aggregate of 910,161 Shares, issuable under the Registrant's
2014 Plan and 227,540 Shares, issuable under the Registrant's 2014 ESPP, which was filed with the SEC on April 14, 2015.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration Statement No. [333-211439](http://www.sec.gov/Archives/edgar/data/1501756/000119312516594488/d193914ds8.htm) pertaining to the registration of (i) an aggregate of 4,708,288 Shares, issuable under the
Registrant's 2014 Plan, (ii) an aggregate of 258,587 Shares issuable under the 2014 ESPP and (iii) an aggregate of 1,194,000 Shares, issuable upon the exercise of stock options granted to three new employees of the Registrant as an
inducement material to acceptance of employment with the Registrant, in accordance with the inducement grant exception under Nasdaq Listing Rule 5635(c)(4), which was filed with the SEC on May 18, 2016.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration Statement No. [333-218465](http://www.sec.gov/Archives/edgar/data/1501756/000119312517193055/d409270ds8.htm) pertaining to the registration of (i) an aggregate of 1,672,200 Shares, issuable under the
Registrant's 2014 Plan, (ii) an aggregate of 418,050 Shares, issuable under the 2014 ESPP and (iii) an aggregate of 200,000 Shares, issuable upon the exercise of stock options and an aggregate of 100,000 shares, issuable upon
settlement of restricted stock units granted to Leone Patterson, each as an inducement material to acceptance of employment with the Registrant, in accordance with the inducement grant exception under Nasdaq Listing Rule 5635(c)(4), which was filed
with the SEC on June 2, 2017.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration Statement No. [333-220894](http://www.sec.gov/Archives/edgar/data/1501756/000119312517307248/d463313ds8.htm) pertaining to the registration of (i) an aggregate of 600,000 Shares, issuable under the
Registrant's 2017 Inducement Plan, as amended and restated (the "2017 Plan") and (ii) an aggregate of 305,000 Shares, issuable upon the exercise of stock options granted to new employees of the Registrant as an inducement
material to acceptance of employment with the Registrant, in accordance with the inducement grant exception under Nasdaq Listing Rule 5635(c)(4), which was filed with the SEC on October 10, 2017.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration Statement No. [333-223894](http://www.sec.gov/Archives/edgar/data/1501756/000119312518094349/d545593ds8.htm) pertaining to the registration of (i) an aggregate of 1,960,613 Shares, issuable under the
Registrant's 2014 Plan, (ii) an aggregate of 490,153 Shares, issuable under the 2014 ESPP and (iii) an aggregate of 225,000 Shares, issuable upon settlement of restricted stock units granted to the Registrant's employees, which
was filed with the SEC on March 23, 2018.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration Statement No. [333-230138](http://www.sec.gov/Archives/edgar/data/1501756/000119312519067443/d720230ds8.htm) , as amended by Post-Effective Amendment No. 1 thereto filed on March 12, 2019, pertaining to
the registration of (i) an aggregate of 2,518,618 Shares, issuable under the Registrant's 2014 Plan, (ii) an aggregate of 629,654 Shares, issuable under the Registrant's 2014 ESPP and (iii) an aggregate of 1,000,000
Shares, issuable under the Registrant's 2017 Plan, which was filed with the SEC on March 7, 2019.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration Statement No. [333-233135](http://www.sec.gov/Archives/edgar/data/1501756/000119312519216899/d783588ds8.htm) pertaining to the registration of an aggregate of 1,500,000 Shares, issuable under the
Registrant's 2017 Plan, which was filed with the SEC on August 8, 2019.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration Statement No. [333-237136](http://www.sec.gov/Archives/edgar/data/1501756/000119312520071731/d825175ds8.htm) pertaining to the registration of an aggregate of 2,691,529 Shares, issuable under the
Registrant's 2014 Plan and an aggregate of 672,882 Shares, issuable under the Registrant's 2014 ESPP, which was filed with the SEC on March 12, 2020.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration Statement No. [333-243761](http://www.sec.gov/Archives/edgar/data/1501756/000119312520215063/d28949ds8.htm) pertaining to the registration of an aggregate of 1,500,000 Shares, issuable under the Registrant's
2017 Plan, which was filed with the SEC on August 10, 2020.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration Statement No. [333-253727](http://www.sec.gov/Archives/edgar/data/1501756/000119312521063725/d61904ds8.htm) , pertaining to the registration of an aggregate of 5,496,254 Shares, issuable under the
Registrant's 2014 Plan, 2014 ESPP and 2017 Plan, which was filed with the SEC on March 1, 2021.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration Statement No. [333-263954](http://www.sec.gov/Archives/edgar/data/1501756/000119312522088232/d354832ds8.htm) , pertaining to the registration of an aggregate of 3,935,223 Shares, issuable under the
Registrant's 2014 Plan, which was filed with the SEC on March 29, 2022.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration Statement No. [333-266794](http://www.sec.gov/Archives/edgar/data/1501756/000119312522218636/d387352ds8.htm) , pertaining to the registration of an aggregate of 5,800,000 Shares, issuable under the
Registrant's 2014 ESPP, which was filed with the SEC on August 11, 2022.

------

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration Statement No. [333-271001](http://www.sec.gov/Archives/edgar/data/1501756/000119312523085717/d479712ds8.htm) , pertaining to the registration of an aggregate of 4,004,695 Shares, issuable under the
Registrant's 2014 Plan, which was filed with the SEC on March 30, 2023.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration Statement No. [333-278046](http://www.sec.gov/Archives/edgar/data/1501756/000119312524070214/d758456ds8.htm) , pertaining to the registration of an aggregate of 4,057,333 Shares, issuable under the
Registrant's 2014 Plan, which was filed with the SEC on March 18, 2024.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration Statement No. [333-280567](http://www.sec.gov/Archives/edgar/data/1501756/000119312524172227/d623076ds8.htm) , pertaining to the registration of an aggregate of 4,688,345 Shares, issuable under the
Registrant's 2024 Equity Incentive Award Plan (the "2024 Plan"), which was filed with the SEC on June 28, 2024.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration Statement No. [333-283935](http://www.sec.gov/Archives/edgar/data/1501756/000119312524282019/d758019ds8.htm) pertaining to the registration of an aggregate of 150,000 Shares, issuable under the Registrant's
2017 Plan, which was filed with the SEC on December 19, 2024.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration Statement No. [333-285358](http://www.sec.gov/Archives/edgar/data/1501756/000119312525039358/d871552ds8.htm) pertaining to the registration of an aggregate of 250,000 Shares, issuable under the Registrant's
2017 Plan, which was filed with the SEC on February 27, 2025.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration Statement No. [333-288187](http://www.sec.gov/Archives/edgar/data/1501756/000119312525143640/d68468ds8.htm) , pertaining to the registration of an aggregate of 2,100,000 Shares, issuable under the
Registrant's 2024 Plan, which was filed with the SEC on June 20, 2025.

On December 9, 2025, pursuant to an Agreement and Plan of Merger (the "Merger Agreement"), dated as of October 24, 2025, by and among the Registrant, Eli Lilly and Company ("Parent") and Flying Tigers Acquisition Corporation ("Purchaser"), Purchaser merged with and into the Registrant (the "Merger"), with the Registrant continuing as the surviving corporation and becoming a wholly owned subsidiary of Parent. As a result of the transactions contemplated by the Merger Agreement, the Registrant has terminated any and all offerings and sales of securities pursuant to the Registration Statements. In accordance with the undertakings made by the Registrant in each Registration Statement to remove from registration, by means of a post-effective amendment, any of the securities of the Registrant registered under such Registration Statement which remain unsold at the termination of the offering, the Registrant hereby terminates the effectiveness of each Registration Statement and removes from registration all of the securities that remain unsold under each Registration Statement as of the date hereof, if any. Each Registration Statement is hereby amended, as appropriate, to reflect the deregistration of such securities. After giving effect to these Post-Effective Amendments, there will be no remaining securities registered by the Registrant pursuant to the Registration Statements.

The foregoing description of the Merger, the Merger Agreement and the transactions contemplated thereby does not purport to be complete and is subject to, and qualified in its entirety by, the Merger Agreement, which is attached as Exhibit 2.1 to the Registrant's Current Report on Form 8-K filed with the SEC on October 24, 2025.

------

**SIGNATURE** 

Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused these Post-Effective Amendments to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Indianapolis, State of Indiana, on December 9, 2025.

---

| | |
|:---|:---|
| **ADVERUM BIOTECHNOLOGIES, INC.** | **ADVERUM BIOTECHNOLOGIES, INC.** |
| By: | /s/ Jonathan R. Haug |
|  | Name: Jonathan R. Haug |
|  | Title: President |

---

No other person is required to sign these Post-Effective Amendments in reliance upon Rule 478 under the Securities Act of 1933, as amended.