# EDGAR Filing Document

**Accession Number:** 0001597553
**File Stem:** 0001193125-23-040721
**Filing Date:** 2023-2
**Character Count:** 18574
**Document Hash:** d59bdb3d4c04fc9d935b584c18dd0e15
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-23-040721.hdr.sgml**: 20230216

**ACCESSION NUMBER**: 0001193125-23-040721

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 7

**FILED AS OF DATE**: 20230216

**DATE AS OF CHANGE**: 20230216

**EFFECTIVENESS DATE**: 20230216

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Sage Therapeutics, Inc.
- **CENTRAL INDEX KEY:** 0001597553
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-269818
- **FILM NUMBER:** 23637150

**BUSINESS ADDRESS:**
- **STREET 1:** 215 FIRST STREET
- **CITY:** CAMBRIDGE
- **STATE:** MA
- **ZIP:** 02142
- **BUSINESS PHONE:** 617-299-8380

**MAIL ADDRESS:**
- **STREET 1:** 215 FIRST STREET
- **CITY:** CAMBRIDGE
- **STATE:** MA
- **ZIP:** 02142

**As filed with the Securities and Exchange Commission on February 16, 2023** 

**Registration No. 333-<u> </u>** 

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**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**Washington, D.C. 20549** 

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**FORM S-8** 

**REGISTRATION STATEMENT** 

***UNDER***

***THE SECURITIES ACT OF 1933***

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## SAGE THERAPEUTICS, INC.
**(Exact Name of Registrant as Specified in Its Charter)** 

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---

| | |
|:---|:---|
| **Delaware** | **27-4486580** |
| **(State or Other Jurisdiction of**<br> **Incorporation or Organization)** | **(I.R.S. Employer**<br> **Identification No.)** |

---

---

| | |
|:---|:---|
| **215 First Street**<br> **Cambridge, MA 02142** | **02142** |
| **(Address of Principal Executive Offices)** | **(Zip Code)** |

---

**Sage Therapeutics, Inc. 2014 Stock Option and Incentive Plan** 

**(Full Title of the Plan)** 

**Barry E. Greene** 

**President and Chief Executive Officer** 

**Sage Therapeutics, Inc.** 

**215 First Street** 

**Cambridge, MA 02142** 

**(Name and Address of Agent For Service)** 

**(617) 299-8380**

**(Telephone Number, Including Area Code, of Agent For Service)** 

***Copies to:***

**Anne Marie Cook** 

**Senior Vice President, General Counsel** 

**Sage Therapeutics, Inc.** 

**215 First Street** 

**Cambridge, MA 02142** 

**(617) 299-8380**

**Stuart M. Falber, Esq.** 

**Rosemary G. Reilly, Esq.** 

**Wilmer Cutler Pickering Hale and Dorr LLP** 

**60 State Street** 

**Boston, MA 02109** 

**(617) 526-6000**

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Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☒ | Accelerated filer | ☐ |
| Non-accelerated filer | ☐ | Smaller reporting company | ☐ |
|  |  | Emerging growth company | ☐ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

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**EXPLANATORY NOTE** 

This Registration Statement on Form S-8 registers additional shares of common stock, par value $0.0001 per share ("Common Stock"), issuable under the Sage Therapeutics, Inc. (the "Registrant") 2014 Stock Option and Incentive Plan, as amended (the "Plan"). The number of shares of Common Stock reserved and available for issuance under the Plan is subject to an automatic annual increase on each January 1 by an amount equal to four percent of the number of shares of Common Stock issued and outstanding on the immediately preceding December 31 or such lesser number of shares of Common Stock as determined by the Administrator (as defined in the Plan). Accordingly, on January 1, 2023, the number of shares of Common Stock reserved and available for issuance under the Plan increased by 2,380,365 shares. This Registration Statement registers these additional 2,380,365 shares of Common Stock. The additional shares are of the same class as other securities relating to the Plan for which a registration statement on Form S-8 has previously been filed and is effective. The information contained in the following registration statements filed on Form S-8 by the Registrant is hereby incorporated by reference pursuant to General Instruction E, except in each case with respect to "Item 8. Exhibits" thereof:

1) Registration Statement on [Form S-8](http://www.sec.gov/Archives/edgar/data/1597553/000119312514272368/d761316ds8.htm) (Registration No. 333-197498) filed on July 18, 2014;

2) Registration Statement on [Form S-8](http://www.sec.gov/Archives/edgar/data/1597553/000119312515206166/d933338ds8.htm) (Registration No. 333-204549) filed on May 29, 2015;

3) Registration Statement on [Form S-8](http://www.sec.gov/Archives/edgar/data/1597553/000119312516485782/d19572ds8.htm) (Registration No. 333-209831) filed on February 29, 2016;

4) Registration Statement on [Form S-8](http://www.sec.gov/Archives/edgar/data/1597553/000119312517054061/d257723ds8.htm) (Registration No. 333-216202) filed on February 23, 2017;

5) Registration Statement on [Form S-8](http://www.sec.gov/Archives/edgar/data/1597553/000119312518054049/d543638ds8.htm) (Registration No. 333-223146) filed on February 22, 2018;

6) Registration Statement on [Form S-8](http://www.sec.gov/Archives/edgar/data/1597553/000119312519043509/d708411ds8.htm) (Registration No. 333-229732) filed on February 19, 2019;

7) Registration Statement on [Form S-8](http://www.sec.gov/Archives/edgar/data/1597553/000119312520051038/d851502ds8.htm) (Registration No. 333-236680) filed on February 27, 2020;

8) Registration Statement on [Form S-8](http://www.sec.gov/Archives/edgar/data/1597553/000119312521053398/d138684ds8.htm) (Registration No. 333-253431) filed on February 24, 2021; and

9) Registration Statement on [Form S-8](http://www.sec.gov/Archives/edgar/data/1597553/000119312522051121/d106955ds8.htm) (Registration No. 333-262948) filed on February 24, 2022.

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**Part II** 

**INFORMATION REQUIRED IN THE REGISTRATION STATEMENT** 

**Item 8. Exhibits.** 

---

| | |
|:---|:---|
| **Exhibit**<br> **No.** | **Description** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.1 | [Specimen Common Stock Certificate (incorporated by reference to Exhibit 4.1 of the Registrant's Registration Statement on Form S-1, as amended (File No. 333-196849) filed on July 8, 2014)](http://www.sec.gov/Archives/edgar/data/1597553/000119312514262688/d697091dex41.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.2 | [Fifth Amended and Restated Certificate of Incorporation of the Registrant, as currently in effect (incorporated by reference to Exhibit 3.1 of the Registrant's Current Report on Form 8-K (File No. 001-36544) filed on July 25, 2014)](http://www.sec.gov/Archives/edgar/data/1597553/000119312514279676/d763105dex31.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.3 | [Amended and Restated Bylaws of the Registrant, as amended on August 6, 2020 (incorporated by reference to Exhibit 3.1 of the Registrant's Quarterly Report on Form 10-Q (File No. 001-36544) filed on August 10, 2020)](http://www.sec.gov/Archives/edgar/data/1597553/000156459020038597/sage-ex31_289.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.1\* | [Opinion of Wilmer Cutler Pickering Hale and Dorr LLP](d456485dex51.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;23.1\* | [Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting Firm](d456485dex231.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;23.2\* | [Consent of Wilmer Cutler Pickering Hale and Dorr LLP (included in Exhibit 5.1)](d456485dex51.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;24.1\* | [Power of Attorney (included on the signature pages of this registration statement)](d456485ds8.htm#sig) |
| &nbsp;&nbsp;&nbsp;&nbsp;99.1 | [2014 Stock Option and Incentive Plan and forms of agreements thereunder (incorporated by reference to Exhibit 10.2 to the Registrant's Registration Statement on Form S-1, as amended (File No. 333-196849) filed on July 8, 2014)](http://www.sec.gov/Archives/edgar/data/1597553/000119312514262688/d697091dex102.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;99.2 | [Form of Performance-Based Restricted Stock Unit Award Agreement Under the Sage Therapeutics, Inc. 2014 Stock Option and Incentive Plan (incorporated by reference to Exhibit 10.1 to the Registrant's Quarterly Report on Form 10-Q (File No. 001-36544) filed on August 10, 2020)](http://www.sec.gov/Archives/edgar/data/1597553/000156459020038597/sage-ex101_204.htm) |
| 107\* | [Filing Fee Table](d456485dexfilingfees.htm) |

---

\* Filed herewith.

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**SIGNATURES** 

Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Cambridge, Commonwealth of Massachusetts, on the 16th day of February, 2023.

---

| | |
|:---|:---|
|  **SAGE THERAPEUTICS, INC.** | **SAGE THERAPEUTICS, INC.** |
|  By: | /s/ Barry E. Greene |
|  | Barry E. Greene |
|  | Chief Executive Officer, President<br> and Director |

---

**POWER OF ATTORNEY AND SIGNATURES** 

We, the undersigned officers and directors of Sage Therapeutics, Inc., hereby severally constitute and appoint Barry E. Greene and Kimi Iguchi, and each of them singly (with full power to each of them to act alone), our true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution in each of them for him or her and in his or her name, place and stead, and in any and all capacities, to sign for us and in our names in the capacities indicated below any and all amendments (including post-effective amendments) to this Registration Statement on Form S-8, and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite or necessary to be done in and about the premises, as full to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents or any of them, or their or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the date indicated below.

---

| | | |
|:---|:---|:---|
| **Signature** | **Title** | **Date** |
| /s/ Barry E. Greene<br> Barry E. Greene | Chief Executive Officer, President and<br> Director (Principal Executive Officer) | February 16, 2023 |
| /s/ Kimi Iguchi<br> Kimi Iguchi | Chief Financial Officer (Principal<br> Financial and Accounting Officer) | February 16, 2023 |
| /s/ Michael F. Cola<br> Michael F. Cola | Director | February 16, 2023 |
| /s/ Steven Paul, M.D.<br> Steven Paul, M.D. | Director | February 16, 2023 |
| /s/ Kevin P. Starr<br> Kevin P. Starr | Director | February 16, 2023 |

---

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| | | |
|:---|:---|:---|
| /s/ James Frates<br> James Frates | Director | February 16, 2023 |
| /s/ Geno Germano<br> Geno Germano | Director | February 16, 2023 |
| /s/ Jeffrey M. Jonas, M.D.<br> Jeffrey M. Jonas, M.D. | Director | February 16, 2023 |
| /s/ Elizabeth Barrett<br> Elizabeth Barrett | Director | February 16, 2023 |
| /s/ George Golumbeski, Ph.D.<br> George Golumbeski, Ph.D. | Director | February 16, 2023 |

---

## Exhibit 5.1

**Exhibit 5.1**![LOGO](g456485g0215025339943.jpg)

February 16, 2023 Sage Therapeutics, Inc. 215 First Street Cambridge, MA 02142 +1 617-526-6000 (t) +1 617 526 5000 (f) wilmerhale.com

Re: 2014 Stock Option and Incentive Plan

Ladies and Gentlemen:

We have assisted in the preparation of a Registration Statement on Form S-8 (the "Registration Statement") to be filed with the Securities and Exchange Commission (the "Commission") under the Securities Act of 1933, as amended (the "Securities Act"), relating to an aggregate of 2,380,365 shares of common stock, $0.0001 par value per share (the "Shares"), of Sage Therapeutics, Inc., a Delaware corporation (the "Company"), issuable under the Company's 2014 Stock Option and Incentive Plan (the "Plan").

We have examined the Certificate of Incorporation and Bylaws of the Company, each as amended and restated to date, and originals, or copies certified to our satisfaction, of all pertinent records of the meetings of the board of directors and stockholders of the Company, the Registration Statement, the Plan and such other documents relating to the Company as we have deemed material for the purposes of this opinion.

In our examination of the foregoing documents, we have assumed the genuineness of all signatures, the authenticity of all documents submitted to us as originals, the conformity to original documents of all documents submitted to us as certified, photostatic or other copies, the authenticity of the originals of any such documents and the legal competence of all signatories to such documents.

We assume that the appropriate action will be taken, prior to the offer and sale of the Shares in accordance with the Plan, to register and qualify the Shares for sale under all applicable state securities or "blue sky" laws.

We express no opinion herein as to the laws of any state or jurisdiction other than the General Corporation Law of the State of Delaware.

It is understood that this opinion is to be used only in connection with the offer and sale of the Shares while the Registration Statement is in effect.

Please note that we are opining only as to the matters expressly set forth herein, and no opinion should be inferred as to any other matters.

Based on the foregoing, we are of the opinion that the Shares have been duly authorized for issuance and, when the Shares are issued and paid for in accordance with the terms and conditions of the Plan, the Shares will be validly issued, fully paid and nonassessable.

![LOGO](g456485g0215030649990.jpg)

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| | |
|:---|:---|
| Sage Therapeutics, Inc.<br> February 16, 2023<br> Page 2 | ![LOGO](g456485g0215030650193.jpg) |

---

We hereby consent to the filing of this opinion with the Commission in connection with the Registration Statement in accordance with the requirements of Item 601(b)(5) of Regulation S-K under the Securities Act. In giving such consent, we do not hereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations of the Commission.

---

| | |
|:---|:---|
| Very truly yours, | Very truly yours, |
| By: | /s/ Wilmer Cutler Pickering Hale and Dorr LLP |
|  | WILMER CUTLER PICKERING HALE AND DORR LLP |

---

## Exhibit 23.1

**Exhibit 23.1** 

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in this Registration Statement on Form S-8 of Sage Therapeutics, Inc. of our report dated February 16, 2023 relating to the financial statements and the effectiveness of internal control over financial reporting, which appears in Sage Therapeutics, Inc.'s Annual Report on Form 10-K for the year ended December 31, 2022.

---

| |
|:---|
|  /s/ PricewaterhouseCoopers LLP<br> Boston, Massachusetts |
|  February 16, 2023 |

---

## Ex-Filing

**Exhibit 107** 

**Calculation of Filing Fee Tables** 

**Form S-8** 

(Form Type)

**Sage Therapeutics, Inc.** 

(Exact Name of Registrant as Specified in its Charter)

**Table 1—Newly Registered Securities** 

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;&nbsp;**Security Type** | **Security Class**<br> **Title** | **Fee<br>Calculation<br>Rule** | **Amount<br>Registered<br>(1)** | **Proposed<br>Maximum<br>Offering<br>Price Per<br>Unit** | **Maximum**<br> **Aggregate**<br> **Offering**<br> **Price** | **Fee**<br> **Rate** | **Amount of<br>Registration<br>Fee** |
| &nbsp;&nbsp;&nbsp;Equity | Common Stock, $0.0001 par value per share | Other | 2380365 (2) | $44.43 (3) | $105759616.95 (3) | 0.00011020 | $11654.71 |
| &nbsp;&nbsp;&nbsp;**Total Offering Amounts** | &nbsp;&nbsp;&nbsp;**Total Offering Amounts** | &nbsp;&nbsp;&nbsp;**Total Offering Amounts** | &nbsp;&nbsp;&nbsp;**Total Offering Amounts** |  | $105759616.95 |  | $11654.71 |
| &nbsp;&nbsp;&nbsp;**Total Fee Offsets** | &nbsp;&nbsp;&nbsp;**Total Fee Offsets** | &nbsp;&nbsp;&nbsp;**Total Fee Offsets** | &nbsp;&nbsp;&nbsp;**Total Fee Offsets** |  |  |  |  |
| &nbsp;&nbsp;&nbsp;**Net Fee Due** | &nbsp;&nbsp;&nbsp;**Net Fee Due** | &nbsp;&nbsp;&nbsp;**Net Fee Due** | &nbsp;&nbsp;&nbsp;**Net Fee Due** |  |  |  | $11654.71 |

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(1) Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this
registration statement shall also cover any additional securities which become issuable with respect to the securities identified in the table above by reason of any stock dividend, stock split, recapitalization or any other similar transaction.

(2) Represents an automatic increase to the number of shares available for issuance under the Plan, effective
January 1, 2023. Shares available for issuance under the Plan were previously registered on registration statements on Form S-8 filed with the Securities and Exchange Commission on July 18, 2014
(Registration No. 333-197498), May 29, 2015 (Registration No. 333-204549), February 29, 2016 (Registration No. 333-209831), February 23, 2017 (Registration No. 333-216202), February 22, 2018 (Registration No. 333-223146), February 19, 2019 (Registration No. 333-229732), February 27, 2020 (Registration No. 333-236680), February 24, 2021 (Registration No. 333-253431), and February 24, 2022 (Registration No. 333-262948).

(3) Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and 457(h) of the
Securities Act of 1933, as amended, and based upon the average of the high and low prices of the Registrant's Common Stock as reported on the Nasdaq Global Market on February 10, 2023.