# EDGAR Filing Document

**Accession Number:** 0001501989
**File Stem:** 0000950170-25-105053
**Filing Date:** 2025-8
**Character Count:** 18697
**Document Hash:** 3ff0b893d1033c41b1fda63b77193663
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000950170-25-105053.hdr.sgml**: 20250807

**ACCESSION NUMBER**: 0000950170-25-105053

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 11

**CONFORMED PERIOD OF REPORT**: 20250807

**ITEM INFORMATION**: Results of Operations and Financial Condition

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20250807

**DATE AS OF CHANGE**: 20250807

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** CytomX Therapeutics, Inc.
- **CENTRAL INDEX KEY:** 0001501989
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 273521219
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-37587
- **FILM NUMBER:** 251194277

**BUSINESS ADDRESS:**
- **STREET 1:** 151 OYSTER POINT BLVD.
- **STREET 2:** SUITE 400
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080
- **BUSINESS PHONE:** 650.515.3185

**MAIL ADDRESS:**
- **STREET 1:** 151 OYSTER POINT BLVD.
- **STREET 2:** SUITE 400
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080

?xml version='1.0' encoding='ASCII'? 8-K

**UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549**

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## **FORM** 8-K

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**CURRENT REPORT**

**Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934**

**Date of Report (Date of earliest event reported):** August 07, 2025<br>

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CytomX Therapeutics, Inc.

**(Exact name of Registrant as Specified in Its Charter)**

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| | | |
|:---|:---|:---|
| Delaware | 001-37587 | 27-3521219 |
| **(State or Other Jurisdiction<br>of Incorporation)** | **(Commission File Number)** | **(IRS Employer<br>Identification No.)** |
| 151 Oyster Point Blvd<br>Suite 400 |  |  |
| South San Francisco**,** California |  | 94080 |
| **(Address of Principal Executive Offices)** |  | **(Zip Code)** |

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**Registrant's Telephone Number, Including Area Code:** 650 515-3185<br>

**(Former Name or Former Address, if Changed Since Last Report)**

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Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

**Securities registered pursuant to Section 12(b) of the Act:**

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| | | |
|:---|:---|:---|
| **<br>Title of each class** | **Trading<br>Symbol(s)** | **<br>Name of each exchange on which registered** |
| Common Stock, $0.00001 par value per share | CTMX | Nasdaq Global Select Market |

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Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

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## **Item 2.02 Results of Operations and Financial Condition.** 
On August 7, 2025, CytomX Therapeutics, Inc., a Delaware corporation (the "Company") issued a press release reporting its unaudited financial results for the three and six months ended June 30, 2025. A copy of the press release is furnished herewith as Exhibit 99.1.

The information in Item 2.02 of this Form 8-K, including Exhibit 99.1 attached hereto, is being furnished and shall not be deemed "filed" for purposes of Section 18 of the Securities and Exchange Act of 1934, as amended, or otherwise subject to the liabilities of that Section or Sections 11 and 12(a)(2) of the Securities Act of 1933, as amended. The information contained in this Item 2.02 and in the accompanying Exhibit 99.1 shall not be incorporated by reference into any filing with the Securities and Exchange Commission made by the Company, whether made before or after the date hereof, regardless of any general incorporation language in such filing.

## **Item 9.01 Financial Statements and Exhibits.** 
**(d) Exhibits.** 

The following exhibit is furnished as part of this report.

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| | |
|:---|:---|
| **<u>Exhibit No.</u>** | **<u>Description</u>** |
| 99.1 | [<u>Press release titled "CytomX Therapeutics Announces Second Quarter of 2025 Financial Results and Provides Business Update" issued by CytomX Therapeutics, Inc. on August 7, 2025.</u>](ctmx-ex99_1.htm) |
| 104 | Cover Page Interactive Data File (embedded within the Inline XBRL document) |

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**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

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| | | | |
|:---|:---|:---|:---|
|  |  |  | **CYTOMX THERAPEUTICS, INC.** |
| Date: | August 7, 2025 | By:  | /s/ Christopher W. Ogden |
|  |  |  | Christopher W. Ogden<br>Chief Financial Officer |

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## Exhibit 99.1

**Exhibit 99.1**

**CytomX Therapeutics Announces Second Quarter 2025 Financial Results and Provides** 

**Business Update**

*- May 12, 2025 announcement of positive interim data from ongoing Phase 1 study of CX-2051 (EpCAM Antibody Drug Conjugate) in patients with advanced colorectal cancer (CRC) -* 

*- CX-2051 Phase 1 dose expansions on track for data update in Q1 2026.* 

*Phase 2 study initiation in CRC anticipated 1H 2026 -* 

*- Combination dose escalation initiated of CX-801 masked interferon alpha-2b with KEYTRUDA®(pembrolizumab) in patients with advanced melanoma -*

*- Completed $100 million underwritten offering of common stock -*

*- Company to host conference call today at 5 p.m. EST / 2 p.m. PST -*

**SOUTH SAN FRANCISCO, Calif., August 7, 2025 –** CytomX Therapeutics, Inc. (Nasdaq: CTMX), a leader in the field of masked, conditionally activated biologics, today announced second quarter 2025 financial results and provided a business update.

"Q2 2025 was an exciting quarter for CytomX as we announced positive initial clinical results for CX-2051 in advanced colorectal cancer, a very challenging disease to treat. Our data highlight CX-2051's intentional design as a first-in-class, masked EpCAM-directed ADC with potential to improve upon the standard of care in late-line CRC. We are also delighted to have completed a financing with top-tier investors that enables CytomX to rapidly advance the CX-2051 development program. Looking ahead, we remain highly focused on our next anticipated CX-2051 clinical data update in Q1 2026 and to potentially launching a Phase 2 study in the first half of 2026," said Sean McCarthy, D.Phil., chief executive officer and chairman of CytomX.

**Q2 2025 Pipeline Program Updates:** 

**CX-2051 (EpCAM PROBODY Topo-1 ADC)** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Announced positive interim data from ongoing Phase 1 dose escalation study of first-in-class EpCAM Antibody Drug Conjugate (CX-2051) in patients with advanced colorectal cancer (CRC).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Initiated CX-2051 dose expansions at the 7.2 mg/kg, 8.6 mg/kg, and 10 mg/kg doses, administered every three weeks (Q3W).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Phase 1 data update in advanced CRC in approximately 70 patients is expected by Q1 2026.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Planning underway for CX-2051 Phase 2 study initiation in advanced, late-line CRC in 1H 2026.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Potential to initiate CX-2051 combination studies in earlier lines of CRC therapy in 2026.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Evaluation ongoing of multiple non-CRC, EpCAM-expressing tumor indications for potential future CX-2051 development.

**CX-801 (PROBODY Interferon alpha-2b)**

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Phase 1 dose escalation of CX-801 monotherapy continues. Preliminary tumor biomarker, pharmacodynamic (PD) and pharmacokinetic (PK) data evaluating the initial molecular performance of CX-801 monotherapy in the ongoing Phase 1 study are expected in the fourth quarter of 2025.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•In May 2025, Phase 1 dose escalation of CX-801 in combination with KEYTRUDA® was initiated. Initial clinical data for the combination therapy in advanced melanoma is anticipated in 2026.

KEYTRUDA® is a registered trademark of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA

**Corporate and Financial:** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•**Financial:** 

oCompleted $100 million ($93.4 million net proceeds) underwritten offering of common stock.

oCytomX ended the second quarter of 2025 with $158.1 million of cash, cash equivalents and investments with expected cash runway to the second quarter of 2027.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•**Research collaborations**:

oPresented preclinical data for mRNA encoded masked IL-12 molecule in collaboration with Moderna at AACR Annual Meeting showing potent anti-tumor activity with significantly enhanced tolerability vs. unmasked IL-12 molecule.

oMultiple drug discovery programs continue across our research collaborations with a focus on bispecific immunotherapies, including T-cell engagers. CytomX has research collaborations with Bristol Myers Squibb, Amgen, Astellas, Regeneron, and Moderna.

**Second Quarter 2025 Financial Results:** 

Cash, cash equivalents and investments totaled $158.1 million as of June 30, 2025, compared to $79.9 million as of March 31, 2025.

Total revenue was $18.7 million for the quarter ended June 30, 2025, compared to $25.1 million for the quarter ended June 30, 2024. The decrease in revenue was driven primarily by the completion of our performance obligations in the Bristol Myers Squibb collaboration, the decision not to further develop the CX-904 program in the Amgen agreement, and a decrease in Moderna activities due to Moderna budget considerations.

Total operating expense in the second quarter of 2025 was $19.9 million compared to $33.6 million in the second quarter of 2024, a decrease of $13.7 million.

Research and development expenses were $13.3 million for the three months ended June 30, 2025, a decrease of $11.9 million compared to the corresponding period of 2024. Reduced research and development expenses were primarily due to a one-time milestone payment of $5M to Immunogen for the first patient dosed in Phase 1 with CX-2051 in Q2 2024, a reduction in CX-904 spend due to program de-prioritization in 2025, and reduced research expenses following the Q1 2025 restructuring.

General and administrative expenses were $6.6 million for the three months ended June 30, 2025, a decrease of $1.8 million compared to the corresponding period of 2024. The decrease in general and administrative expenses was primarily driven by personnel costs as well as patent and legal expenses.

**About CytomX Therapeutics**

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**CytomX Therapeutics Forward-Looking Statements**

This press release includes forward-looking statements. Such forward-looking statements involve known and unknown risks, uncertainties and other important factors that are difficult to predict, may be beyond our control, and may cause the actual results, performance, or achievements to be materially different from any future results, performance or achievements expressed or implied in such statements, including those related to CX-2051. Accordingly, you should not rely on any of these forward-looking statements, including those relating to the potential benefits, safety and efficacy or progress of CytomX's or any of its collaborative partners' product candidates, including CX-2051 and CX-801, the potential benefits or applications of CytomX's PROBODY® therapeutic platform, CytomX's or its collaborative partners' ability to develop and advance product candidates into and successfully complete clinical trials, including the ongoing and planned clinical trials of CX-2051 and CX-801 and the timing of initial and ongoing data availability for our clinical trials, including CX-2051 and CX-801, and other development milestones. Risks and uncertainties that contribute to the uncertain nature of the forward-looking statements include: the unproven nature of CytomX's novel PROBODY® therapeutic technology; uncertainties around the Company's ability to raise sufficient funds to carry out its planned research and development; CytomX's clinical trial product candidates are in the initial stages of clinical development and its other product candidates are currently in preclinical development, and the process by which preclinical and clinical development could potentially lead to an approved product is long and subject to significant risks and uncertainties, including the possibility that the results of preclinical research and early clinical trials, including initial CX-2051 results, may not be predictive of future results; the possibility that CytomX's clinical trials will not be successful; the possibility that current preclinical research may not result in additional product candidates; CytomX's dependence on the success of CX-2051 and CX-801; CytomX's reliance on third parties for the manufacture of the Company's product candidates; possible regulatory developments in the United States and foreign countries, including China and the European Union; and the risk that we may incur higher costs than expected for research and development or unexpected costs and expenses. Additional applicable risks and uncertainties include those relating to our preclinical research and development, clinical development, and other risks identified under the heading "Risk Factors" included in CytomX's Quarterly Report on Form 10-Q filed with the SEC on August 7, 2025. The forward-looking statements contained in this press release are based on information currently available to CytomX and speak only as of the date on which they are made. CytomX does not undertake and

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specifically disclaims any obligation to update any forward-looking statements, whether as a result of any new information, future events, changed circumstances or otherwise.

PROBODY is a U.S. registered trademark of CytomX Therapeutics, Inc. All other trademarks are the properties of their respective owners.

**Company Contact:**

Chris Ogden

SVP, Chief Financial Officer

cogden@cytomx.com

**Investor Contact:**

Precision AQ (formerly Stern Investor Relations)

Stephanie Ascher

Stephanie.Ascher@precisionaq.com

**Media Contact:**

Redhouse Communications

Teri Dahlman

<u>teri@redhousecomms.com</u>

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**CYTOMX THERAPEUTICS, INC.**

**CONDENSED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME**

**(in thousands, except share and per share data)**

**(Unaudited)**

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| | | |
|:---|:---|:---|
|  | **Three Months Ended** | **Three Months Ended** |
|  | **June 30,** | **June 30,** |
|  | **2025** | **2024** |
| Revenues | $18658 | $25115 |
| Operating expenses: |  |  |
| &nbsp;&nbsp;&nbsp;Research and development | 13322 | 25172 |
| &nbsp;&nbsp;&nbsp;General and administrative | 6622 | 8395 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total operating expenses | 19944 | 33567 |
| Loss from operations | (1286) | (8452) |
| &nbsp;&nbsp;&nbsp;Interest income | 1178 | 1971 |
| &nbsp;&nbsp;&nbsp;Other (expense) income, net | 17 | (2) |
| Loss before income taxes | (91) | (6483) |
| &nbsp;&nbsp;&nbsp;Provision for income taxes | 63 | 51 |
| Net Loss | (154) | (6534) |
| Other comprehensive loss: |  |  |
| &nbsp;&nbsp;&nbsp;Unrealized gain on investments, net of tax | 34 | 6 |
| Total comprehensive loss | $(120) | $(6528) |
| Net loss per share: |  |  |
| &nbsp;&nbsp;&nbsp;Basic | $(0.00) | $(0.08) |
| &nbsp;&nbsp;&nbsp;Diluted | $(0.00) | $(0.08) |
| Shares used to compute net loss per share |  |  |
| &nbsp;&nbsp;&nbsp;Basic | 129075546 | 84880632 |
| &nbsp;&nbsp;&nbsp;Diluted | 129075546 | 84880632 |

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**CYTOMX THERAPEUTICS, INC.**

**CONDENSED BALANCE SHEETS**

**(in thousands)**

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| | | |
|:---|:---|:---|
|  | **June 30,** | **December 31,** |
|  | **2025** | **2024** |
|  | **(unaudited)** | **(1)** |
| **Assets** |  |  |
| Current assets: |  |  |
| &nbsp;&nbsp;&nbsp;Cash and cash equivalents | $49041 | $38052 |
| &nbsp;&nbsp;&nbsp;Short-term investments | 109046 | 62571 |
| &nbsp;&nbsp;&nbsp;Accounts receivable | 1869 | 3103 |
| &nbsp;&nbsp;&nbsp;Prepaid expenses and other current assets | 4665 | 3579 |
| Total current assets | 164621 | 107305 |
| Property and equipment, net | 1946 | 2467 |
| Intangible assets, net | 510 | 583 |
| Goodwill | 949 | 949 |
| Restricted cash | 1028 | 1027 |
| Operating lease right-of-use asset | 5947 | 8136 |
| Other assets | 56 | 66 |
| Total assets | $175057 | $120533 |
| **Liabilities and Stockholders' Equity (Deficit)** |  |  |
| Current liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;Accounts payable | $227 | $1088 |
| &nbsp;&nbsp;&nbsp;Accrued liabilities | 11503 | 12338 |
| &nbsp;&nbsp;&nbsp;Operating lease liabilities - short term | 5443 | 5145 |
| &nbsp;&nbsp;&nbsp;Deferred revenue, current portion | 22050 | 67201 |
| Total current liabilities | 39223 | 85772 |
| Deferred revenue, net of current portion | 10241 | 26862 |
| Operating lease liabilities - long term | 1442 | 4240 |
| Other long term liabilities | 4241 | 4115 |
| Total liabilities | 55147 | 120989 |
| Commitments and contingencies |  |  |
| Stockholders' equity (deficit): |  |  |
| &nbsp;&nbsp;&nbsp;Convertible preferred stock |  |  |
| &nbsp;&nbsp;&nbsp;Common stock | 2 | 1 |
| &nbsp;&nbsp;&nbsp;Additional paid-in capital | 788083 | 691095 |
| &nbsp;&nbsp;&nbsp;Accumulated other comprehensive (loss) income | 33 | 27 |
| &nbsp;&nbsp;&nbsp;Accumulated deficit | (668208) | (691579) |
| Total stockholders' equity (deficit) | 119910 | (456) |
| Total liabilities and stockholders' equity (deficit) | $175057 | $120533 |

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(1)The condensed balance sheet as of December 31, 2024 was derived from the audited financial statements included in the Company's Annual Report on Form 10-K for the year ended December 31, 2024.

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