# EDGAR Filing Document

**Accession Number:** 0000879407
**File Stem:** 0001628280-25-038858
**Filing Date:** 2025-8
**Character Count:** 166007
**Document Hash:** 32ad870fe0f88c7238b8833d34eafddd
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001628280-25-038858.hdr.sgml**: 20250807

**ACCESSION NUMBER**: 0001628280-25-038858

**CONFORMED SUBMISSION TYPE**: 10-Q

**PUBLIC DOCUMENT COUNT**: 97

**CONFORMED PERIOD OF REPORT**: 20250630

**FILED AS OF DATE**: 20250807

**DATE AS OF CHANGE**: 20250807

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** ARROWHEAD PHARMACEUTICALS, INC.
- **CENTRAL INDEX KEY:** 0000879407
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 460408024
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 0930

**FILING VALUES:**
- **FORM TYPE:** 10-Q
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-38042
- **FILM NUMBER:** 251193847

**BUSINESS ADDRESS:**
- **STREET 1:** 177 E COLORADO BLVD
- **STREET 2:** SUITE 700
- **CITY:** PASADENA
- **STATE:** CA
- **ZIP:** 91105
- **BUSINESS PHONE:** 626-696-4702

**MAIL ADDRESS:**
- **STREET 1:** 177 E COLORADO BLVD
- **STREET 2:** SUITE 700
- **CITY:** PASADENA
- **STATE:** CA
- **ZIP:** 91105

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ARROWHEAD RESEARCH CORP
- **DATE OF NAME CHANGE:** 20040112

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** INTERACTIVE GROUP INC
- **DATE OF NAME CHANGE:** 20020509

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** INTERACTIVE INC
- **DATE OF NAME CHANGE:** 19940224

?xml version='1.0' encoding='ASCII'? arwr-20250630

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, DC 20549**

_____________________________________

**FORM 10-Q**

_____________________________________

**(Mark One)**

⌧ **QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934**

**For the quarterly period ended** June 30, 2025

□ **TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934**

**For the transition period from&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; to&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;** 

**Commission file number 001-38042**

_____________________________________

**ARROWHEAD PHARMACEUTICALS, INC.**

**(Exact name of registrant as specified in its charter)** 

_____________________________________

---

| | |
|:---|:---|
| **Delaware** | **46-0408024** |
| **(State or other jurisdiction of incorporation or organization)** | **(I.R.S. Employer Identification No.)** |

---

**177 E. Colorado Blvd, Suite 700**

**Pasadena, California 91105**

**(626) 304-3400**

**(Address and telephone number of principal executive offices)** 

Former name, former address, and former fiscal year, if changed since last report: N/A

_____________________________________

**Securities registered pursuant to Section 12(b) of the Exchange Act:**

---

| | | |
|:---|:---|:---|
| **Title of each class** | **Trading Symbol(s)** | **Name of each exchange on which registered** |
| **Common Stock, par value $0.001 per share** | **ARWR** | **The Nasdaq Global Select Market** |

---

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ⌧ No □

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ⌧ No □

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large Accelerated Filer | ⌧ | Accelerated Filer | □ |
| Non-Accelerated Filer | □ | Smaller Reporting Company | □ |
| Emerging Growth Company | □ | | |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. □

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes □ No ⌧

The number of shares of the registrant's common stock outstanding as of August 1, 2025 was 138,257,550.

------

---

| | |
|:---|:---|
| | **Page(s)** |
| **<u>[PART I — FINANCIAL INFORMATION](#ib8da3572c2184cf591d7511966d9e9c1_10)</u>** | |
| <u>[ITEM 1. FINANCIAL STATEMENTS](#ib8da3572c2184cf591d7511966d9e9c1_13)</u> | [1](#ib8da3572c2184cf591d7511966d9e9c1_13) |
| &nbsp;&nbsp;&nbsp;&nbsp;<u>[Consolidated Balance Sheets](#ib8da3572c2184cf591d7511966d9e9c1_16)</u> | [1](#ib8da3572c2184cf591d7511966d9e9c1_16) |
| &nbsp;&nbsp;&nbsp;&nbsp;<u>[Consolidated Statements of Operations and Comprehensive](#ib8da3572c2184cf591d7511966d9e9c1_19)[(Loss)](#ib8da3572c2184cf591d7511966d9e9c1_19)[Income](#ib8da3572c2184cf591d7511966d9e9c1_19)</u> | [2](#ib8da3572c2184cf591d7511966d9e9c1_19) |
| &nbsp;&nbsp;&nbsp;&nbsp;<u>[Consolidated Statements of Stockholders' Equity](#ib8da3572c2184cf591d7511966d9e9c1_22)</u> | [3](#ib8da3572c2184cf591d7511966d9e9c1_22) |
| &nbsp;&nbsp;&nbsp;&nbsp;<u>[Consolidated Statements of Cash Flows](#ib8da3572c2184cf591d7511966d9e9c1_25)</u>  | [4](#ib8da3572c2184cf591d7511966d9e9c1_25) |
| &nbsp;&nbsp;&nbsp;&nbsp;<u>[Notes to Consolidated Financial Statements](#ib8da3572c2184cf591d7511966d9e9c1_28)</u> | [5](#ib8da3572c2184cf591d7511966d9e9c1_28) |
| <u>[ITEM 2. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS](#ib8da3572c2184cf591d7511966d9e9c1_73)</u> | [27](#ib8da3572c2184cf591d7511966d9e9c1_73) |
| <u>[ITEM 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK](#ib8da3572c2184cf591d7511966d9e9c1_91)</u> | [35](#ib8da3572c2184cf591d7511966d9e9c1_91) |
| <u>[ITEM 4. CONTROLS AND PROCEDURES](#ib8da3572c2184cf591d7511966d9e9c1_94)</u> | [35](#ib8da3572c2184cf591d7511966d9e9c1_94) |
| **<u>[PART II — OTHER INFORMATION](#ib8da3572c2184cf591d7511966d9e9c1_97)</u>** | [36](#ib8da3572c2184cf591d7511966d9e9c1_97) |
| <u>[ITEM 1. LEGAL PROCEEDINGS](#ib8da3572c2184cf591d7511966d9e9c1_100)</u> | [36](#ib8da3572c2184cf591d7511966d9e9c1_100) |
| <u>[ITEM 1A. RISK FACTORS](#ib8da3572c2184cf591d7511966d9e9c1_103)</u> | [36](#ib8da3572c2184cf591d7511966d9e9c1_103) |
| <u>[ITEM 2. UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS](#ib8da3572c2184cf591d7511966d9e9c1_106)</u> | [36](#ib8da3572c2184cf591d7511966d9e9c1_106) |
| <u>[ITEM 3. DEFAULTS UPON SENIOR SECURITIES](#ib8da3572c2184cf591d7511966d9e9c1_109)</u> | [36](#ib8da3572c2184cf591d7511966d9e9c1_109) |
| <u>[ITEM 4. MINE SAFETY DISCLOSURES](#ib8da3572c2184cf591d7511966d9e9c1_112)</u> | [36](#ib8da3572c2184cf591d7511966d9e9c1_112) |
| <u>[ITEM 5. OTHER INFORMATION](#ib8da3572c2184cf591d7511966d9e9c1_115)</u> | [36](#ib8da3572c2184cf591d7511966d9e9c1_115) |
| <u>[ITEM 6. EXHIBITS](#ib8da3572c2184cf591d7511966d9e9c1_121)</u> | [37](#ib8da3572c2184cf591d7511966d9e9c1_121) |
| <u>[SIGNATURE](#ib8da3572c2184cf591d7511966d9e9c1_124)</u> | [38](#ib8da3572c2184cf591d7511966d9e9c1_124) |

---

------

**PART I. FINANCIAL INFORMATION** 

**ITEM 1.&nbsp;&nbsp;&nbsp;&nbsp;FINANCIAL STATEMENTS** 

**Arrowhead Pharmaceuticals, Inc.**

**Consolidated Balance Sheets** 

**(in thousands, except per share amounts)**

---

| | | |
|:---|:---|:---|
| | **June 30, 2025** | **September 30, 2024** |
| | **(unaudited)** | |
| **ASSETS** | | |
| Current assets: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Cash, cash equivalents and restricted cash | $129793 | $102685 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accounts receivable | 9699 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Available-for-sale securities, at fair value | 770579 | 578276 |
| &nbsp;&nbsp;&nbsp;&nbsp;Prepaid expenses | 23692 | 9537 |
| &nbsp;&nbsp;&nbsp;&nbsp;Other current assets | 13160 | 4973 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total current assets | 946923 | 695471 |
| Property, plant and equipment, net | 381048 | 386032 |
| Intangible assets, net | 7286 | 8562 |
| Right-of-use assets | 44002 | 45255 |
| Other assets | 1353 | 4482 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**Total Assets** | $**1380612** | $**1139802** |
| **LIABILITIES, NONCONTROLLING INTEREST AND STOCKHOLDERS' EQUITY** |  |  |
| Current liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Accounts payable | $33050 | $11388 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accrued expenses | 64818 | 63017 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accrued payroll and benefits | 19298 | 21989 |
| &nbsp;&nbsp;&nbsp;&nbsp;Lease liabilities | 7010 | 6342 |
| &nbsp;&nbsp;&nbsp;&nbsp;Deferred revenue | 22979 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Credit facility | 40000 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Other liabilities | 7375 | 432 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total current liabilities | 194530 | 103168 |
| Long-term liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Lease liabilities, net of current portion | 105690 | 111027 |
| &nbsp;&nbsp;&nbsp;&nbsp;Liability related to the sale of future royalties | 360254 | 341361 |
| &nbsp;&nbsp;&nbsp;&nbsp;Credit facility, net of current portion | 200332 | 393183 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total long-term liabilities | 666276 | 845571 |
| Commitments and contingencies (Note 7) |  |  |
| Noncontrolling interest and stockholders' equity: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Common stock, $0.001 par value:<br>Authorized 290,000 shares; issued and outstanding 138,144 and 124,376 shares | 230 | 217 |
| &nbsp;&nbsp;&nbsp;&nbsp;Additional paid-in capital | 2120130 | 1806000 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accumulated other comprehensive income | 5357 | 4750 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accumulated deficit | (1603404) | (1625523) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Stockholders' equity | 522313 | 185444 |
| &nbsp;&nbsp;&nbsp;&nbsp;Noncontrolling interest | (2507) | 5619 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total noncontrolling interest and stockholders' equity | 519806 | 191063 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**Total Liabilities, Noncontrolling Interest and Stockholders' Equity** | $**1380612** | $**1139802** |

---

*The accompanying notes are an integral part of these unaudited consolidated financial statements.* 

------

**Arrowhead Pharmaceuticals, Inc.**

**Consolidated Statements of Operations and Comprehensive (Loss) Income**

**(in thousands, except per share amounts)**

**(unaudited)** 

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended June 30,** | **Three Months Ended June 30,** | **Nine Months Ended June 30,** | **Nine Months Ended June 30,** |
| | **2025** | **2024** | **2025** | **2024** |
| **Revenue** | $**27767** | $**—** | $**572976** | $**3551** |
| **Operating expenses:** |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Research and development | 162368 | 152431 | 432472 | 370044 |
| &nbsp;&nbsp;&nbsp;&nbsp;General and administrative | 30949 | 23710 | 86264 | 72384 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total operating expenses | **193317** | **176141** | **518736** | **442428** |
| Operating (loss) income | (165550) | (176141) | 54240 | (438877) |
| **Other (expense) income:** |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Interest income | 11019 | 6498 | 28236 | 15550 |
| &nbsp;&nbsp;&nbsp;&nbsp;Interest expense | (24382) | (5094) | (67667) | (17705) |
| &nbsp;&nbsp;&nbsp;&nbsp;Other, net | (176) | 760 | 603 | 1370 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total other (expense) income | **(13539)** | **2164** | **(38828)** | **(785)** |
| (Loss) income before income tax expense and noncontrolling interest | **(179089)** | **(173977)** | **15412** | **(439662)** |
| &nbsp;&nbsp;&nbsp;&nbsp;Income tax (benefit) expense | (437) |  | 1419 | (3313) |
| Net (loss) income including noncontrolling interest | $**(178652)** | $**(173977)** | $**13993** | $**(436349)** |
| Net loss attributable to noncontrolling interest, net of tax | (3411) | (3184) | (8126) | (7392) |
| Net (loss) income attributable to Arrowhead Pharmaceuticals, Inc. | $(175241) | $(170793) | $22119 | $(428957) |
| Net (loss) income per share attributable to Arrowhead Pharmaceuticals, Inc.: |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Basic | $(1.26) | $(1.38) | $0.17 | $(3.63) |
| &nbsp;&nbsp;&nbsp;&nbsp;Diluted | $(1.26) | $(1.38) | $0.17 | $(3.63) |
| Weighted-average shares used in calculating |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Basic | 139039 | 124199 | 132385 | 118260 |
| &nbsp;&nbsp;&nbsp;&nbsp;Diluted | 139039 | 124199 | 133352 | 118260 |
| Other comprehensive income (loss), net of tax: |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Unrealized gains on available-for-sale securities | 876 | 249 | 1022 | 2374 |
| &nbsp;&nbsp;&nbsp;&nbsp;Foreign currency translation adjustments | 91 | (141) | (415) | (139) |
| Comprehensive (loss) income | $**(177685)** | $**(173869)** | $**14600** | $**(434114)** |

---

*The accompanying notes are an integral part of these unaudited consolidated financial statements.* 

------

**Arrowhead Pharmaceuticals, Inc.**

**Consolidated Statements of Stockholders' Equity** 

**(in thousands)**

**(unaudited)**

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| | **Common**<br>**Stock** | **Amount ($)** | **Additional**<br>**Paid-In**<br>**Capital** | **Accumulated** <br>**Other** <br>**Comprehensive** <br>**Income** | **Accumulated**<br>**Deficit** | **Non-<br>controlling Interest** | **Total** |
| **Balance at September 30, 2024** | **124376** | $**217** | $**1806000** | $**4750** | $**(1625523)** | $**5619** | $**191063** |
| &nbsp;&nbsp;Stock-based compensation |  |  | 15209 |  |  |  | **15209** |
| &nbsp;&nbsp;Exercise of stock options | 70 |  | 634 |  |  |  | **634** |
| &nbsp;&nbsp;Common stock - restricted stock units vesting | 209 |  |  |  |  |  | **—** |
| &nbsp;&nbsp;Issuance of pre-funded warrants |  |  | 25000 |  |  |  | **25000** |
| &nbsp;&nbsp;Foreign currency translation adjustments |  |  |  | (106) |  |  | **(106)** |
| &nbsp;&nbsp;Unrealized losses on available-for-sale securities |  |  |  | (507) |  |  | **(507)** |
| &nbsp;&nbsp;Net loss |  |  |  |  | (173085) | (2133) | **(175218)** |
| **Balance at December 31, 2024** | **124655** | $**217** | $**1846843** | $**4137** | $**(1798608)** | $**3486** | $**56075** |
| &nbsp;&nbsp;Stock-based compensation |  |  | 16027 |  |  |  | **16027** |
| &nbsp;&nbsp;Exercise of stock options | 353 |  | 2619 |  |  |  | **2619** |
| &nbsp;&nbsp;Common stock - restricted stock units vesting | 1128 | 1 |  |  |  |  | **1** |
| &nbsp;&nbsp;Common stock issued | 11926 | 12 | 241375 |  |  |  | **241387** |
| &nbsp;&nbsp;Foreign currency translation adjustments |  |  |  | (400) |  |  | **(400)** |
| &nbsp;&nbsp;Unrealized gains on available-for-sales securities |  |  |  | 653 |  |  | **653** |
| &nbsp;&nbsp;Net income |  |  |  |  | 370445 | (2582) | **367863** |
| **Balance at March 31, 2025** | **138062** | $**230** | $**2106864** | $**4390** | $**(1428163)** | $**904** | $**684225** |
| &nbsp;&nbsp;Stock-based compensation |  |  | 13043 |  |  |  | **13043** |
| &nbsp;&nbsp;Exercise of stock options | 36 |  | 223 |  |  |  | **223** |
| &nbsp;&nbsp;Common stock - restricted stock units vesting | 46 |  |  |  |  |  | **—** |
| &nbsp;&nbsp;Foreign currency translation adjustments |  |  |  | 91 |  |  | **91** |
| &nbsp;&nbsp;Unrealized gains on available-for-sales securities |  |  |  | 876 |  |  | **876** |
| Net loss |  |  |  |  | (175241) | (3411) | **(178652)** |
| **Balance at June 30, 2025** | **138144** | $**230** | $**2120130** | $**5357** | $**(1603404)** | $**(2507)** | $**519806** |

---

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| | **Common**<br>**Stock** | **Amount ($)** | **Additional**<br>**Paid-In**<br>**Capital** | **Accumulated** <br>**Other** <br>**Comprehensive** <br>**Loss** | **Accumulated**<br>**Deficit** | **Non-<br>controlling Interest** | **Total** |
| **Balance at September 30, 2023** | **107312** | $**200** | $**1300395** | $**(3222)** | $**(1026030)** | $**15819** | $**287162** |
| &nbsp;&nbsp;Stock-based compensation |  |  | 19694 |  |  |  | **19694** |
| &nbsp;&nbsp;Exercise of stock options | 34 |  | 267 |  |  |  | **267** |
| &nbsp;&nbsp;Common stock - restricted stock units vesting | 154 |  |  |  |  |  | **—** |
| &nbsp;&nbsp;Foreign currency translation adjustments |  |  |  | 58 |  |  | **58** |
| &nbsp;&nbsp;Unrealized gains on available-for-sale securities |  |  |  | 1909 |  |  | **1909** |
| &nbsp;&nbsp;Net loss |  |  |  |  | (132864) | (2512) | **(135376)** |
| **Balance at December 31, 2023** | **107500** | $**200** | $**1320356** | $**(1255)** | $**(1158894)** | $**13307** | $**173714** |
| &nbsp;&nbsp;Stock-based compensation |  |  | 17750 |  |  |  | **17750** |
| &nbsp;&nbsp;Exercise of stock options | 120 |  | 1512 |  |  |  | **1512** |
| &nbsp;&nbsp;Common stock - restricted stock units vesting | 723 | 1 | (1) |  |  |  | **—** |
| &nbsp;&nbsp;Common stock issued, net of offering costs | 15790 | 16 | 429249 |  |  |  | **429265** |
| &nbsp;&nbsp;Foreign currency translation adjustments |  |  |  | (56) |  |  | **(56)** |
| &nbsp;&nbsp;Unrealized gains on available-for-sale securities |  |  |  | 216 |  |  | **216** |
| &nbsp;&nbsp;Net loss |  |  |  |  | (125300) | (1696) | **(126996)** |
| **Balance at March 31, 2024** | **124133** | $**217** | $**1768866** | $**(1095)** | $**(1284194)** | $**11611** | $**495405** |
| &nbsp;&nbsp;Stock-based compensation |  |  | 17050 |  |  |  | **17050** |
| &nbsp;&nbsp;Exercise of stock options | 43 |  | 388 |  |  |  | **388** |
| &nbsp;&nbsp;Common stock - restricted stock units vesting | 51 |  |  |  |  |  | **—** |
| &nbsp;&nbsp;Foreign currency translation adjustments |  |  |  | (141) |  |  | **(141)** |
| &nbsp;&nbsp;Unrealized gains on available-for-sale securities |  |  |  | 249 |  |  | **249** |
| &nbsp;&nbsp;Net loss |  |  |  |  | (170793) | (3184) | **(173977)** |
| **Balance at June 30, 2024** | **124227** | $**217** | $**1786304** | $**(987)** | $**(1454987)** | $**8427** | $**338974** |

---

*The accompanying notes are an integral part of these unaudited consolidated financial statements.*

------

**Arrowhead Pharmaceuticals, Inc.**

**Consolidated Statements of Cash Flows** 

**(in thousands)**

**(unaudited)**

---

| | | |
|:---|:---|:---|
| | **Nine Months Ended June 30,** | **Nine Months Ended June 30,** |
| | **2025** | **2024** |
| CASH FLOWS FROM OPERATING ACTIVITIES: |  |  |
| &nbsp;&nbsp;&nbsp;Net income (loss) | $13993 | $(436349) |
| &nbsp;&nbsp;&nbsp;&nbsp;Adjustments to reconcile net income (loss) to net cash flow from operating activities |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Stock-based compensation | 44279 | 54494 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Depreciation and amortization | 17542 | 13570 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(Accretion) amortization of note premiums/discounts | (4545) | 7886 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Realized loss on investments |  | (80) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Non-cash interest expense on liability related to the sale of future royalties | 18893 | 17705 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Non-cash interest expense on credit facility | 48774 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Changes in operating assets and liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Accounts receivable | (9841) |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Prepaid expenses and other assets | (22342) | (1746) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Accounts payable | 21662 | 2785 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Accrued expenses | 7956 | 13086 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Deferred revenue | 22979 | (866) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Operating lease, net | (3417) | 3880 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Other | 3128 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net cash provided by (used in) operating activities | 159061 | (325635) |
| CASH FLOWS FROM INVESTING ACTIVITIES: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Purchases of property and equipment | (15177) | (117180) |
| &nbsp;&nbsp;&nbsp;&nbsp;Purchases of investments | (774616) | (428611) |
| &nbsp;&nbsp;&nbsp;&nbsp;Proceeds from sales and maturities of investments | 587880 | 348642 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net cash used in investing activities | (201913) | (197149) |
| CASH FLOWS FROM FINANCING ACTIVITIES: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Proceeds from the exercises of stock options | 3476 | 2166 |
| &nbsp;&nbsp;&nbsp;&nbsp;Proceeds from the issuance of common stock, net of offering costs |  | 429265 |
| &nbsp;&nbsp;&nbsp;&nbsp;Proceeds from the sales of future royalties |  | 50000 |
| &nbsp;&nbsp;&nbsp;&nbsp;Proceeds from the issuance of warrants | 25000 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Payments of debt issuance costs | (5000) |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Proceeds from the issuance of common stock | 241388 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Repayments of credit facility | (201625) |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Proceeds from Visirna credit agreement | 7098 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net cash provided by financing activities | 70337 | 481431 |
| &nbsp;&nbsp;&nbsp;&nbsp;Net increase (decrease) in cash, cash equivalents and restricted cash | 27485 | (41353) |
| Effect of exchange rate on cash, cash equivalents and restricted cash | (377) | (139) |
| CASH, CASH EQUIVALENTS AND RESTRICTED CASH: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;BEGINNING OF PERIOD | 102685 | 110891 |
| &nbsp;&nbsp;&nbsp;&nbsp;END OF PERIOD | $129793 | $69399 |
| **Supplementary disclosure of cash flows:** |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Interest paid | $(19) | $— |
| &nbsp;&nbsp;&nbsp;&nbsp;Income taxes paid | $(81) | $(3062) |
| **Supplemental disclosure of non-cash investing activities:** |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Capital expenditures included in accrued expenses | $346 | $6909 |

---

*The accompanying notes are an integral part of these unaudited consolidated financial statements.*

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**Arrowhead Pharmaceuticals, Inc.**

**Notes to Consolidated Financial Statements** 

**(unaudited)**

**NOTE 1. ORGANIZATION AND SIGNIFICANT ACCOUNTING POLICIES**

***General and Recent Developments***

Arrowhead Pharmaceuticals, Inc. and its subsidiaries (referred to herein collectively as the "Company") are primarily engaged in developing medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, the Company's therapies trigger the RNA interference mechanism to induce rapid, deep and durable knockdown of target genes. RNA interference ("RNAi") is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. The Company's RNAi-based therapeutics may leverage this natural pathway of gene silencing to target and shut down specific disease-causing genes.

The following table presents the Company's current pipeline:

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| | | | |
|:---|:---|:---|:---|
| **Therapeutic Area** | **Name** | **Stage** | **Product Rights** |
| **Cardiometabolic** | plozasiran | Phase 3 | Arrowhead |
|  | zodasiran | Phase 3 | Arrowhead |
|  | olpasiran | Phase 3 | Amgen |
|  | ARO-PNPLA3 | Phase 1 | Arrowhead |
|  | GSK-4532990 | Phase 2b | GSK |
|  | ARO-INHBE | Phase 1/2a | Arrowhead |
|  | ARO-ALK7 | Phase 1/2a | Arrowhead |
| **Pulmonary** | ARO-RAGE | Phase 1/2a | Arrowhead |
|  | SRP-1002 (ARO-MMP7) | Phase 1/2a | Sarepta |
| **Liver** | fazirsiran | Phase 3 | Takeda and Arrowhead |
|  | GSK5637608 | Phase 2 | GSK |
| **Neuromuscular** | SRP-1001 (ARO-DUX4) | Phase 1/2a | Sarepta |
|  | SRP-1003 (ARO-DM1) | Phase 1/2a | Sarepta |
| **Central Nervous System (CNS)** | SRP-1004 (ARO-ATXN2) | Phase 1/2a | Sarepta |
| **Other** | ARO-C3 | Phase 1/2a | Arrowhead |
|  | ARO-CFB | Phase 1/2a | Arrowhead |

---

The Company operates lab facilities in California and Wisconsin, where its research and development activities, including the development of RNAi therapeutics, take place. The Company also operates an active pharmaceutical ingredient manufacturing and supporting laboratory facility in Verona, Wisconsin. The Company's principal executive offices are located in Pasadena, California.

During the first three quarters of fiscal 2025, the Company has continued to develop and advance its pipeline and partnered candidates. The following is a summary of select significant developments affecting our business that have occurred since the filing of our Annual Report on Form 10-K for the fiscal year ended September 30, 2024:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Triggered a $100.0 million milestone payment from Sarepta Therapeutics, Inc., which was triggered on July 27, 2025, when the Company reached the first of two prespecified enrollment targets and subsequent authorization to dose escalate in a Phase 1/2 clinical study of ARO-DM1, an investigational RNAi therapeutic for the treatment of type 1 myotonic dystrophy (DM1);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Announced the signing of an asset purchase agreement between Sanofi and Visirna Therapeutics, a majority-owned subsidiary of the Company, created to develop and commercialize four of the Company's investigational cardiometabolic candidates in Greater China. Under the terms of the agreement, Sanofi will acquire rights to develop and commercialize investigational plozasiran, the Company's first-in-class RNAi therapeutic candidate designed to reduce production of apolipoprotein C-III (APOC3) as a potential treatment for familial chylomicronemia syndrome (FCS) and severe hypertriglyceridemia (SHTG), in Greater China;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Initiated and dosed the first subject in the YOSEMITE Phase 3 clinical trial of zodasiran, the Company's investigational RNAi therapeutic being developed as a potential treatment for homozygous familial

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hypercholesterolemia (HoFH), a rare genetic condition that leads to severely elevated LDL-cholesterol and early onset cardiovascular disease;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Completed enrollment of SHASTA-3, SHASTA-4, and MUIR-3 Phase 3 clinical trials of plozasiran. The Company's global Phase 3 clinical studies are designed to support regulatory submissions for approval of investigational plozasiran in the treatment of severe hypertriglyceridemia. The Company previously submitted a New Drug Application to the U.S. Food and Drug Administration ("FDA") on November 16, 2024 for plozasiran based on positive Phase 3 PALISADE study results in patients with familial chylomicronemia syndrome, which the FDA accepted on January 17, 2025, with a Prescription Drug User Fee Act (PDUFA) action date of November 18, 2025, and indicated it is not currently planning to hold an advisory committee meeting;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Initiated a Phase 1/2a clinical trial of ARO-ALK7 for the treatment of obesity. ARO-ALK7 is the first RNAi-based therapy designed to silence adipocyte expression of the *ACVR1C* gene to reduce the production of Activin receptor-like kinase 7 (ALK7), which acts as a receptor in a pathway that regulates energy homeostasis in adipose tissue;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Announced Topline results from Part 2 of a Phase 1/2 clinical study of ARO-C3, the Company's investigational RNAi therapeutic designed to reduce liver production of complement component 3 (C3) as a potential therapy for various complement mediated diseases. ARO-C3 achieved reductions in alternative pathway complement activity and proteinuria;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Entered into a global licensing and collaboration agreement with Sarepta Therapeutics, Inc ("Sarepta") on November 25, 2024, which closed on February 7, 2025. Closing of the transaction was subject to the expiration or termination of the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976 and other customary conditions. Upon closing, the Company received $325.0 million through the purchase of 11,926,301 shares of Company common stock by Sarepta, at a price per share of $27.25, and received $500.0 million as an upfront payment on February 24, 2025. The Company will also receive $250.0 million to be paid in equal installments over five years and is eligible to receive an additional $300.0 million in near-term payments. Additionally, the Company is eligible to receive royalties on commercial sales and up to approximately $10.0 billion in future potential milestone payments;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• GSK dosed its fifth patient in a Phase 2 trial in December 2024, triggering a $2.5 million milestone payment to the Company which was paid in the second quarter of fiscal 2025;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;***•*** Announced that the Company dosed the first subjects in a Phase 1/2a clinical trial of ARO-INHBE; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Presented interim results from a Phase 1/2a clinical study of ARO-CFB at the 8th Complement-Based Drug Development Summit. The study resulted in multiple findings including: (1) ARO-CFB led to dose dependent reductions in circulating CFB protein by up to 90% with greater than 3 months duration, (2) single and multiple doses of ARO-CFB led to near complete inhibition of alternative pathway activity based on Wieslab AP, and (3) single and multiple doses of ARO-CFB led to near complete inhibition of alternative pathway hemolytic activity, measured by AH50.

***Consolidation and Basis of Presentation***

The interim Consolidated Financial Statements include the accounts of Arrowhead Pharmaceuticals, Inc. and its subsidiaries (wholly-owned subsidiaries and a variable interest entity for which the Company is the primary beneficiary). Subsidiaries refer to Arrowhead Madison, Inc., Arrowhead Australia Pty Ltd., Arrowhead Pharmaceuticals Ireland Limited, Arrowhead Pharmaceuticals NZ Limited and Visirna Therapeutics, Inc. ("Visirna"). For subsidiaries in which the Company owns or is exposed to less than 100% of the economics, the Company records net loss attributable to noncontrolling interests in its consolidated statements of operations equal to the percentage of the economic or ownership interests retained in such entity by the respective noncontrolling party.

The interim Consolidated Financial Statements have been prepared in conformity with U.S. generally accepted accounting principles ("GAAP"). The financial data of the Company included herein are unaudited. In the opinion of management, all material adjustments of a normal recurring nature have been made to present fairly the Company's financial position as of June 30, 2025 and the results of operations and cash flows for the periods presented. All intercompany transactions and balances have been eliminated. Certain prior period amounts have been reclassified to conform with the current period presentation.

Certain financial information that is normally included in annual financial statements prepared in accordance with GAAP, but that is not required for interim reporting purposes, has been omitted from the accompanying interim consolidated financial statements and related notes. Readers are urged to review the Company's Annual Report on Form

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10-K for the fiscal year ended September 30, 2024 for more complete descriptions and discussions. Operating results and cash flows for the nine months ended June 30, 2025 are not necessarily indicative of the results that may be expected for the fiscal year ending September 30, 2025.

***Liquidity***

The Company's primary sources of financing have been through the sale of its equity securities, credit facility, revenue from its licensing and collaboration agreements and the sale of certain future royalties. Research and development activities have required significant investment since the Company's inception and are expected to continue to require significant cash expenditure in the future, particularly as the Company's pipeline of drug candidates and its headcount have both expanded. Additionally, significant investment will be required as the Company's pipeline matures into later stage clinical trials and commercialization efforts.

As of June 30, 2025, the Company had $129.8 million in cash, cash equivalents and restricted cash ($2.2 million in restricted cash) and $770.6 million in available-for-sale securities to fund operations. During the nine months ended June 30, 2025, the Company's cash, cash equivalents and restricted cash and investments balance increased by $219.4 million, which was primarily due to the $500.0 million as an upfront payment under the Sarepta agreement and $325.0 million in the form of an equity investment under the Sarepta agreement, and $25.0 million in the form of pre-funded warrants, partially offset by ongoing expenses related to the Company's research and development programs, $201.6 million payments on its credit facility, and $28.2 million interest income earned on investments.

In total, the Company is eligible to receive up to $13.3 billion in additional developmental, regulatory and sales milestones, and may receive various royalties on net sales from its licensing and collaboration agreements, subject to the terms and conditions of those agreements.

***Summary of Significant Accounting Policies***

There have been no changes to the significant accounting policies disclosed in the Company's most recent Annual Report on Form 10-K for the fiscal year ended September 30, 2024.

***Recent Accounting Pronouncements*** 

In January 2025, the Financial Accounting Standards Board ("FASB") issued Accounting Standard Update ("ASU") 2024-03, *Income Statement—Reporting Comprehensive Income—Expense Disaggregation Disclosures (Subtopic 220-40): Disaggregation of Income Statement Expenses,* in November 2024, and ASU 2025-01, *Clarifying the Effective Date*. These updates require entities to provide disaggregated disclosures of income statement expenses. The ASUs do not affect the expense captions presented on the face of the income statement but instead require the disaggregation of certain expense captions into specified categories within the footnotes to the financial statements. The ASUs will become effective for the Company beginning October 1, 2027, and the Company is currently evaluating the impact on its consolidated financial statements and related disclosures.

In December 2023, the FASB issued ASU 2023-09, *Income Taxes (Topic 740): Improvements to Income Tax Disclosures*, to improve its income tax disclosure requirements. Under the guidance, entities must annually (1) disclose specific categories in the rate reconciliation and (2) provide additional information for reconciling items that meet a quantitative threshold. This ASU will become effective for the Company beginning October 1, 2025, and is not expected to have a material impact on its consolidated financial statements and related disclosures.

In November 2023, the FASB issued ASU 2023-07, *Segment Reporting (Topic 280): Improvements to Reportable Segment Disclosures*, which is intended to improve reportable segment disclosure requirements, primarily through additional disclosures about significant segment expenses. This ASU requires public companies with a single reportable segment to provide all disclosures required under ASC 280. In addition, this ASU requires public companies to include in interim reports all disclosures related to a reportable segment's profit or loss and assets that are currently required in annual reports. While the ASU implements further segment disclosure requirements, it does not change how an entity identifies its operating or reportable segments and it will have no impact on the Company's consolidated financial condition, results of operations or cash flows. The Company plans to adopt the ASU's in connection with our Annual Report on Form 10-K for the fiscal year ending September 30, 2025, as required and will be applied retrospectively to all periods presented.

On July 4, 2025, the One Big Beautiful Bill Act ("OBBBA") was signed into law, which enacts significant changes to U.S. tax and related laws. Some of the provisions of the new tax law affecting corporations include but are not limited to expensing of domestic research expenses, reinstate the limit of the deduction of interest expense to thirty percent of EBITDA, and one hundred percent bonus depreciation on eligible property acquired after January 19, 2025. The Company is currently evaluating the impact the new tax law will have on its financial condition and results of operations.

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Preliminarily, the Company does not anticipate a material change to its effective income tax rate and its net deferred federal income tax assets as the Company maintains a full valuation allowance.

**NOTE 2. COLLABORATION AND LICENSE AGREEMENTS**

The following table provides a summary of revenue recognized:

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| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended June 30,** | **Three Months Ended June 30,** | **Nine Months Ended June 30,** | **Nine Months Ended June 30,** |
| | **2025** | **2024** | **2025** | **2024** |
| | **(in thousands)** | **(in thousands)** | **(in thousands)** | **(in thousands)** |
| GSK | $143 | $— | $2646 | $2685 |
| Takeda |  |  |  | 866 |
| Sarepta | 27624 |  | 570330 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;**Total** | $27767 | $— | $572976 | $3551 |

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The following table summarizes the balance of receivables and contract liabilities related to the Company's collaboration and license agreements:

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| | | |
|:---|:---|:---|
| | **June 30, 2025** | **September 30, 2024** |
| | **(in thousands)** | **(in thousands)** |
| Receivables included in accounts receivable | $9699 | $— |
| Contract liabilities included in deferred revenue | $22979 | $— |

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***GlaxoSmithKline Intellectual Property (No. 3) Limited ("GSK")***

***<u>GSK-HSD License Agreement</u>***

On November 22, 2021, GSK and the Company entered into an Exclusive License Agreement (the "GSK-HSD License Agreement"). Under the GSK-HSD License Agreement, GSK has received an exclusive license for GSK-4532990 (formerly ARO-HSD). The exclusive license is worldwide with the exception of greater China. GSK is wholly responsible for all clinical development and commercialization of GSK-4532990 in its territory.

The Company has completed its performance obligation related to this agreement, and the upfront payment of $120.0 million was fully recognized in the year ended September 30, 2022. Further, GSK dosed the first patient in a Phase 2b trial in March 2023 and paid a $30.0 million milestone payment to the Company in the third quarter of fiscal 2023.

The Company is eligible for an additional payment of $100.0 million upon achieving the first patient dosed in a Phase 3 trial. Furthermore, should the Phase 3 trial read out positively, and the potential new medicine receives regulatory approval in major markets, the deal provides for commercial milestone payments to the Company of up to $190.0 million at first commercial sale, and up to $590.0 million in sales-related milestone payments. The Company is further eligible to receive tiered royalties on net product sales in a range of mid-teens to twenty percent.

***<u>GSK-HBV Agreement</u>***

On December 11, 2023, the Company entered into an Amended and Restated License Agreement with GSK (the "GSK-HBV Agreement") pursuant to which GSK received a worldwide, exclusive license to develop and commercialize daplusiran/tomligisiran (GSK5637608, formerly JNJ-3989), the Company's third-generation subcutaneously administered RNAi therapeutic candidate being developed as a potential therapy for patients with chronic hepatitis B virus infection.

Under the terms of the GSK-HBV Agreement, the Company received $2.7 million in December 2023, upon signing the amended GSK-HBV Agreement. Further, GSK dosed the fifth patient in a Phase 2 trial in December 2024, triggering a $2.5 million milestone payment to the Company which was paid in the second quarter of fiscal 2025. The Company is eligible to receive up to $830.0 million in development and sales milestone payments under the GSK-HBV Agreement.

As of June 30, 2025, the Company had no contract assets and liabilities recorded.

***Takeda Pharmaceutical Company Limited ("Takeda")***

In October 2020, Takeda and the Company entered into an Exclusive License and Co-Funding Agreement (the "Takeda License Agreement"). Under the Takeda License Agreement, Takeda and the Company will co-develop the Company's fazirsiran program (formerly TAK-999 and ARO-AAT), the Company's second-generation subcutaneously administered RNAi therapeutic candidate being developed as a treatment for liver disease associated with alpha-1 antitrypsin deficiency. Within the United States, fazirsiran, if approved, will be co-commercialized under a 50/50 profit

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sharing structure. Outside the United States, Takeda received an exclusive license to commercialize fazirsiran and will lead the global commercialization strategy, while the Company will be eligible to receive tiered royalties of 20% to 25% on net sales.

The Company determined that the key deliverables included the license and certain research and development services including the Company's responsibilities to complete the initial portion of the SEQUOIA study, to complete the ongoing Phase 2 AROAAT2002 study, and to ensure certain manufacturing of fazirsiran drug product is completed and delivered to Takeda (the "Takeda R&D Services"). Due to the specialized and unique nature of these Takeda R&D Services and their direct relationship with the license, the Company determined that these deliverables represent one distinct bundle and, thus, one performance obligation. Takeda is responsible for managing clinical development and commercialization outside the United States. Within the United States, the Company and Takeda are responsible in the co-development and co-commercialization efforts. The Company considers the collaborative activities, including the co-development and co-commercialization, to be a separate unit of account within Topic 808, and as such, these co-funding amounts are recorded as research and development expenses or general and administrative expenses, as appropriate.

Under the terms of the Takeda License Agreement, the Company received $300.0 million as an upfront payment in January 2021 and an additional $40.0 million upon Takeda's initiation of a Phase 3 REDWOOD clinical study of fazirsiran in March 2023, and is eligible to receive up to $527.5 million in additional potential development, regulatory and commercial milestones.

The Company allocated the total $300.0 million initial transaction price to its one distinct performance obligation for the fazirsiran license and the associated Takeda R&D Services. The Company has substantially completed its performance obligation under the Takeda License Agreement by December 31, 2023. As such, all revenue has been fully recognized as of December 31, 2023. There were no further deferred revenue and contract liabilities as of June 30, 2025.

The Company recorded $24.6 million as accrued expenses as of June 30, 2025 that was primarily driven by co-development and co-commercialization activities.

***Janssen Pharmaceuticals, Inc. ("Janssen")***

On April 7, 2023, Janssen voluntarily terminated its collaboration agreement with the Company and the Company regained full rights to ARO-PNPLA3, formerly called JNJ-75220795. There are no currently active trials for ARO-PNPLA3.

Further, on December 11, 2023, the Company entered into the GSK-HBV Agreement, as discussed above, pursuant to which GSK received an exclusive license for JNJ-3989 (formerly ARO-HBV). JNJ-3989 had previously been licensed to Janssen in October 2018.

***Amgen Inc. ("Amgen")***

In September 2016, Amgen and the Company entered into two collaboration and license agreements and a common stock purchase agreement. Under the Second Collaboration and License Agreement (the "Olpasiran Agreement"), Amgen received a worldwide, exclusive license to the Company's novel RNAi olpasiran (previously referred to as AMG- 890 or ARO-LPA) program. These RNAi molecules are designed to reduce elevated lipoprotein(a), which is a genetically validated, independent risk factor for atherosclerotic cardiovascular disease. Under the Olpasiran Agreement, Amgen is wholly responsible for clinical development and commercialization.

The Company has substantially completed its performance obligations under the Olpasiran Agreement. There were no contract assets and liabilities recorded as of June 30, 2025.

In November 2022, Royalty Pharma Investments 2019 ICAV ("Royalty Pharma") and the Company entered into a Royalty Purchase Agreement with Royalty Pharma (the "Royalty Pharma Agreement"). In consideration for the payments under the Royalty Pharma Agreement, Royalty Pharma is entitled to receive all royalties otherwise payable by Amgen to the Company under the Olpasiran Agreement. The Company remains eligible to receive up to an additional $485.0 million in remaining development, regulatory and sales milestone payments payable from Amgen and Royalty Pharma. See Note 11.

***Sarepta Therapeutics, Inc.*** 

On November 25, 2024, the Company entered into an Exclusive License and Collaboration Agreement (the "Sarepta Collaboration Agreement") with Sarepta for the development and commercialization of multiple clinical and preclinical programs in rare, genetic diseases of the muscle, central nervous system, and lungs. The Company concurrently entered into a Stock Purchase Agreement (the "Stock Purchase Agreement") with Sarepta (see Note 6).

Under the Sarepta Collaboration Agreement, Sarepta received an exclusive sublicensable worldwide license to

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SRP-1001 (formerly ARO-DUX4), SRP-1003 (formerly ARO-DM1), SRP-1002 (formerly ARO-MMP7), and SRP-1004 (formerly ARO-ATXN2) clinical stage programs (the "C1" programs). Sarepta also received an exclusive sublicensable worldwide license to the Company's ARO-HTT, ARO-ATXN1, and ARO-ATXN3 preclinical stage programs (the "C2" programs). The Company will perform certain research and development activities for the C1 and C2 programs.

Further, Sarepta may select up to six gene targets for which the Company will perform discovery, optimization and preclinical development activities to identify RNAi compounds against each selected target (the "C3" programs). Upon target acceptance, Sarepta will receive an exclusive license to the Company's intellectual property rights to exploit compounds directed to those targets and is wholly responsible for clinical development and commercialization of each compound after the Company delivers a Clinical Trial Application ready data package (the "CTA package").

The Company identified 17 performance obligations under the Sarepta Collaboration Agreement. The four C1 licenses are distinct performance obligations from the four C1 research and development performance obligations since the customer can use and benefit from the licenses separately. The performance obligations for the licenses were satisfied in the second quarter of fiscal 2025 upon delivery, and the research and development performance obligations will be satisfied as the work is performed. The remaining nine performance obligations include three C2 preclinical stage program licenses and research and development activities, and six C3 unidentified discovery target licenses and research and development activity. Each of the three C2 programs and the six C3 programs were determined to represent one performance obligation, as the customer cannot benefit from the use of the product license at the point of transfer until the specified research and development activities are performed. As such, each of the C2 and C3 product licenses and respective research and development work will be combined to form one performance obligation. For these nine performance obligations, revenue is recognized over time as the work is performed.

For performance obligations recognized over time, the estimated performance period over which revenue will be recognized is determined to be the period over which the Company estimates it will perform the research and development activities. The Company determined that the most appropriate method of measuring progress for these performance obligations is an input method based on research and development costs in the program budget. Accordingly, the Company has estimated the total cost required to complete its obligation and recognized an amount of revenue equal to the proportion of services performed, which is reassessed on an ongoing basis as the program progresses. In the period an agreement expires or is terminated, remaining deferred revenue, if any, is recognized as revenue.

Under the terms of the Sarepta Collaboration Agreement, the Company received an upfront payment of $500.0 million on February 14, 2025. In addition, on February 7, 2025, the Company received $325.0 million in the form of an equity investment under the Stock Purchase Agreement. Based upon the Company's share price on February 7, 2025, (the "Closing Date"), the difference between the $325.0 million and the fair value of the shares on the Closing date resulted in a premium of $83.6 million. The premium is included as part of the total consideration of the Sarepta Collaboration Agreement for revenue recognition purposes. The Company is entitled to receive $250.0 million to be paid in annual installments of $50.0 million over the first five years of the agreement. The Company is also eligible receive reimbursement of certain costs related to carrying out the research and development activities for the C1 programs. The fixed consideration of $833.6 million and an estimated variable consideration of $71.2 million were allocated to all performance obligations based on their relative standalone selling price. Standalone selling prices for the product licenses were determined using an adjusted market-based approach through the net present value of the expected future cash flows for each program. The standalone selling prices for the research and development work were determined based on an expected cost plus margin approach. The fixed and estimated variable consideration of $904.9 million was allocated in accordance to the following table:

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| | |
|:---|:---|
| | **June 30, 2025** |
| | **(in thousands)** |
| Upfront payment | $500000 |
| Annual fees | 250000 |
| Equity premium | 83612 |
| Fixed consideration | $833612 |
| Estimated variable consideration | 71243 |
| Total transaction price | $904855 |

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The Company estimates the stand-alone selling price for each distinct performance obligation, which involves assumptions that may require significant judgment. The Company's estimates of the stand-alone selling price for license-related performance obligations includes forecasted revenues and expenses, phase dates, probability of success, development timelines, and the discount rate. The estimates of the stand-alone selling price for research and development

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or other service-related performance obligations generally include forecasting the expected costs of satisfying a performance obligation at market rates. The Company identified a discount based on the difference between the aggregate stand-alone selling price and the transaction price for accounting revenue recognition purposes. The Company allocated the discount proportionally to each of the performance obligations based upon their standalone selling price.

The Company receives reimbursement of certain costs related to carrying out the research and development activities for the C1 programs and may receive development milestone payments of up to $300.0 million. Further, for each of the 13 programs, the Company is eligible to receive regulatory milestone payments between $110.0 million and $180.0 million per program. Variable consideration associated with the milestones that may be achieved will be allocated to the performance obligation to which it is determined to be related, which will be the respective development work that is being reimbursed and the respective programs to which the milestones relate. ARO-DM1 development milestones were allocated between the license and development work based on the allocation of the standalone selling price. The Company will recognize the ARO-DM1 development milestones and other development milestones as revenue in the periods the underlying milestone events are achieved as achievement of the milestone events are highly susceptible to factors outside of the entity's influence and therefore there is a possibility that the milestone event will not be achieved.

The Company is also eligible to receive sales milestone payments between $500.0 million and $700.0 million per program as well as tiered royalties on net sales of licensed products of up to the low double digits, subject to the terms and conditions of the Sarepta Collaboration Agreement. The Company has applied the sales-based scope exception to the sales milestones and the royalty-based payments.

The Sarepta Collaboration Agreement commenced in February 2025 and may be terminated by either party in the event of a material breach as defined therein. In addition, Sarepta may voluntarily terminate the Sarepta Collaboration Agreement with 30 days' written notice to the Company if terminated prior to any regulatory approval of a licensed product. Unless earlier terminated, the Sarepta Collaboration Agreement expires on a product-by-product and country-by-country basis, upon the date of expiration of the relevant royalty term for such product in such country.

As of June 30, 2025, the Company recorded $570.3 million in revenue from Sarepta, $9.7 million in accounts receivable and $23.0 million in deferred revenue. The recognition of the remaining revenue for the performance obligations is dependent upon the time it takes to complete the respective research and development activities and in consideration of the timing of the selection of the C3 programs.

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**NOTE 3. BALANCE SHEET ACCOUNTS**

***Property, Plant and Equipment***

The following table summarizes the Company's major classes of property, plant and equipment:

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| | | |
|:---|:---|:---|
| | **June 30, 2025** | **September 30, 2024** |
| | **(in thousands)** | **(in thousands)** |
| Land | $2996 | $2996 |
| Buildings | 249245 | 75988 |
| Research equipment | 59561 | 65353 |
| Manufacturing equipment | 16548 |  |
| Furniture | 5594 | 5594 |
| Computers and software | 1059 | 981 |
| Leasehold improvements | 104403 | 104410 |
| Construction in progress | 15872 | 188731 |
|  | 455278 | 444053 |
| Less: Accumulated depreciation and amortization | (74230) | (58021) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Property, plant and equipment, net | $381048 | $386032 |

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Depreciation and amortization expense for property, plant and equipment for the three months ended June 30, 2025 and 2024 was $5.8 million and $4.4 million, respectively. Depreciation and amortization expense for property, plant and equipment for the nine months ended June 30, 2025 and 2024 was $16.2 million and $12.3 million, respectively.

During the first quarter of fiscal 2025, the Company substantially completed the build out of its manufacturing facility in Verona, Wisconsin, leading to the reclassification of $162.7 million from construction in progress to buildings and $2.6 million from construction in progress to manufacturing equipment. The Company subsequently incurred and capitalized $10.6 million to buildings and $13.9 million to manufacturing equipment during the second and third quarters of fiscal 2025. Furthermore, the Company began depreciating the newly completed manufacturing facility over a 39-year period and the manufacturing equipment over 7- or 10-year periods.

During the first quarter of fiscal 2024, the Company completed the build out of its laboratory and office facilities in Verona, Wisconsin, which resulted in the reclassification of $71.8 million from construction in progress to buildings. The Company subsequently incurred and capitalized $4.2 million from construction in progress to buildings in fiscal 2024.

***Accrued Expenses***

Accrued expenses consisted of the following as of:

---

| | | |
|:---|:---|:---|
| | **June 30, 2025** | **September 30, 2024** |
| | **(in thousands)** | **(in thousands)** |
| Accrued research and development expenses | $31708 | $28069 |
| Accrued research and development expenses; co-development | 24627 | 23351 |
| Accrued capital expenditures | 346 | 4206 |
| Other | 8137 | 7391 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total accrued expenses | $64818 | $63017 |

---

As of June 30, 2025, the Company's accrued research and development expenses was primarily attributable to ongoing clinical trial operations, preclinical animal studies, and associated toxicology assessments. In addition, accrued research and development expenses; co-development relates to the co-development and co-commercialization activities under the Takeda License Agreement (see Note 2).

------

**NOTE 4. INVESTMENTS**

The Company's investments consisted of the following:

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **As of June 30, 2025** | **As of June 30, 2025** | **As of June 30, 2025** | **As of June 30, 2025** |
| | **(in thousands)** | **(in thousands)** | **(in thousands)** | **(in thousands)** |
| | **Adjusted Basis** | **Gross<br>Unrealized Gains** | **Gross<br>Unrealized Losses** | **Fair Value** |
| &nbsp;&nbsp;&nbsp;&nbsp;Available-for-sale securities | $768746 | $1938 | $(105) | $770579 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**Total current investments** | $768746 | $1938 | $(105) | $770579 |

---

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **As of September 30, 2024** | **As of September 30, 2024** | **As of September 30, 2024** | **As of September 30, 2024** |
| | **(in thousands)** | **(in thousands)** | **(in thousands)** | **(in thousands)** |
| | **Adjusted Basis** | **Gross<br>Unrealized Gains** | **Gross<br>Unrealized Losses** | **Fair Value** |
| &nbsp;&nbsp;&nbsp;&nbsp;Available-for-sale securities | $577465 | $837 | $(26) | $578276 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**Total current investments** | $577465 | $837 | $(26) | $578276 |

---

The following table summarizes the contract maturity of the available-for-sale securities as of:

---

| | | |
|:---|:---|:---|
| | **June 30, 2025** | **September 30, 2024** |
| | **(in thousands)** | **(in thousands)** |
| &nbsp;&nbsp;&nbsp;&nbsp;Within one year | $224571 | $578276 |
| &nbsp;&nbsp;&nbsp;&nbsp;After one to two years | 450889 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;After two to three years | 95119 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**Total** | $770579 | $578276 |

---

As of June 30, 2025 and September 30, 2024, the gross unrealized losses were immaterial. The Company has determined that the available-for-sale securities that were in an unrealized loss position did not have any credit loss impairment as of June 30, 2025 and 2024.

------

**NOTE 5. INTANGIBLE ASSETS**

Intangible assets subject to amortization include patents and a license agreement capitalized as part of the Novartis RNAi asset acquisition in March 2015. The following table presents the components of intangible assets:

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | **Gross Carrying Amount** | **Accumulated Amortization** | **Impairment** | **Net Carrying Amount** | **Useful Lives** |
| | **(in thousands)** | **(in thousands)** | **(in thousands)** | **(in thousands)** | **(in years)** |
| **As of June 30, 2025** | | | | | |
| &nbsp;&nbsp;&nbsp;&nbsp;Patents | $21728 | $16037 | $— | $5691 | 14 |
| &nbsp;&nbsp;&nbsp;&nbsp;License | 3129 | 1534 |  | 1595 | 21 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**Total intangible assets, net** | $24857 | $17571 | $— | $7286 |  |
| **As of September 30, 2024** |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Patents | $21728 | $14873 | $— | $6855 | 14 |
| &nbsp;&nbsp;&nbsp;&nbsp;License | 3129 | 1422 |  | 1707 | 21 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**Total intangible assets, net** | $24857 | $16295 | $— | $8562 |  |

---

Intangible assets are reviewed annually for impairment and more frequently if potential impairment indicators exist. No impairment indicators were identified during the nine months ended June 30, 2025 and 2024.

Intangible assets with definite useful lives are amortized on a straight-line basis over their useful lives. Intangible assets amortization expense was $0.4 million for the three months ended June 30, 2025 and 2024, and $1.3 million for each of the nine months ended June 30, 2025 and 2024. None of the intangible assets with definite useful lives are anticipated to have a residual value.

The following table presents the estimated future amortization expense related to intangible assets as of June 30, 2025:

---

| | |
|:---|:---|
| | **Amortization Expense** |
| **Year Ending September 30,** | **(in thousands)** |
| 2025 (remainder) | $424 |
| 2026 | 1700 |
| 2027 | 1700 |
| 2028 | 1700 |
| 2029 | 795 |
| 2030 and thereafter | 967 |
| &nbsp;&nbsp;&nbsp;&nbsp;**Total** | $7286 |

---

------

**NOTE 6. STOCKHOLDERS' EQUITY**

The following table summarizes the Company's shares of common stock and preferred stock:

---

| | | | | |
|:---|:---|:---|:---|:---|
| | | **Shares** | **Shares** | **Shares** |
| |<br>**Par Value** | **Authorized** | **Issued** | **Outstanding** |
| | | **(in thousands)** | **(in thousands)** | **(in thousands)** |
| **As of June 30, 2025** | | | | |
| &nbsp;&nbsp;&nbsp;&nbsp;Common stock <sup>(1)</sup> | $0.001 | 290000 | 138144 | 138144 |
| &nbsp;&nbsp;&nbsp;&nbsp;Preferred stock | $0.001 | 5000 |  |  |
| **As of September 30, 2024** |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Common stock | $0.001 | 290000 | 124376 | 124376 |
| &nbsp;&nbsp;&nbsp;&nbsp;Preferred stock | $0.001 | 5000 |  |  |

---

 *&nbsp;&nbsp;&nbsp;&nbsp;(1) Does not include shares of common stock into which the Avoro Pre-Funded Warrants may be exercised.*

As of June 30, 2025 and September 30, 2024, respectively, 10,081,964 and 11,492,293 shares of common stock were reserved for issuance upon exercise of options and vesting of restricted stock units granted or available for grant under the Company's 2013 and 2021 Incentive Plans, as well as for other inducement grants made to new employees under Rule 5635(c)(4) of the Nasdaq Listing Rules.

On November 25, 2024, the Company entered into a Securities Purchase Agreement (the "Securities Purchase Agreement") with an institutional and accredited investor for a private placement of pre-funded warrants to purchase shares of common stock with an exercise price of $0.001 per share ("Avoro Pre-Funded Warrants"). Pursuant to the Securities Purchase Agreement, the Company sold pre-funded warrants to purchase up to 917,441 shares of common stock at a purchase price of $27.25 per pre-funded warrant, for an aggregate value of approximately $25.0 million. The outstanding Avoro Pre-Funded Warrants are exercisable at any time and do not have an expiration date.

The Company determined that the Avoro Pre-Funded Warrants are freestanding financial instruments because they (i) are immediately exercisable, (ii) do not embody an obligation for the Company to repurchase its shares, (iii) permit the holders to receive a fixed number of shares of common stock upon exercise, and (iv) are indexed to the Company's common stock. As such, the Company evaluated the Avoro Pre-Funded Warrants to determine whether they represent instruments that require liability classification pursuant to the guidance in ASC 480. However, the Company concluded that the Avoro Pre-Funded Warrants are not a liability within the scope of ASC 480 due to their characteristics. Further, the Company determined that the Avoro Pre-Funded Warrants do not meet the definition of a derivative under ASC 815 because they do not meet the criteria regarding no or little initial net investment. Accordingly, the Company assessed the Avoro Pre-Funded Warrants relative to the guidance in ASC 815-40, *Contracts in Entity's Own Equity*, to determine the appropriate treatment. The Company concluded that the Avoro Pre-funded Warrants are both indexed to its own stock and meet all other conditions for equity classification. Accordingly, the Company has classified the Avoro Pre-funded Warrants as permanent equity. As of June 30, 2025, no shares underlying the Avoro Pre-Funded Warrants had been exercised.

In connection with the Sarepta Collaboration Agreement, on November 25, 2024, the Company entered into the Stock Purchase Agreement with an affiliate of Sarepta for a private placement of shares of common stock of the Company (the "Private Placement"). Pursuant to the Stock Purchase Agreement, the Company sold 11,926,301 shares of common stock, at a price per share of $27.25, for an aggregate value of approximately $325.0 million. The Private Placement closed on February 7, 2025.

On December 2, 2022, the Company entered into an open market sale agreement (the "Open Market Sale Agreement"), pursuant to which the Company may, from time to time, sell up to $250,000,000 in shares of the Company's common stock through Jefferies LLC, acting as the sales agent and/or principal, in an at-the-market offering ("ATM Offering"). The Company is not required to sell shares under the Open Market Sale Agreement. The Company will pay Jefferies LLC a commission of up to 3.0% of the aggregate gross proceeds received from all sales of the common stock under the Open Market Sale Agreement. Unless otherwise terminated, the ATM Offering shall terminate upon the earlier of (i) the sale of all shares of common stock subject to the Open Market Sale Agreement and (ii) the termination of the Open Market Sale Agreement as permitted therein. The Company and Jefferies may each terminate the Open Market Sale Agreement at any time upon prior notice. As of June 30, 2025, no shares have been issued under the Open Market Sale Agreement.

------

**NOTE 7. COMMITMENTS AND CONTINGENCIES**

***Litigation***

From time to time, the Company may be subject to various claims and legal proceedings in the ordinary course of business. If the potential loss from any claim, asserted or unasserted, or legal proceeding is considered probable and the amount is reasonably estimable, the Company will accrue a liability for the estimated loss. There were no contingent liabilities recorded as of June 30, 2025.

***Commitments***

The Company owns land in the Verona Technology Park in Verona, Wisconsin, where it has constructed an approximately 160,000 square foot drug manufacturing facility and an approximately 140,000 square foot laboratory and office facility to support manufacturing process development and analytical activities.

As of June 30, 2025, the build-out of these facilities was substantially completed, with total costs incurred of $293.2 million. These costs included (i) $76.0 million capitalized to building, related to the laboratory and office facility, and (ii) $11.5 million capitalized to research equipment, $173.3 million capitalized to building, $16.5 million capitalized to manufacturing equipment, and $15.9 million in construction in progress, related to the drug manufacturing facility. The Company has an expected outstanding balance of approximately $3.3 million remaining to be settled.

**NOTE 8. LEASES**

**<u>Pasadena, California</u>**: The Company leases 49,000 square feet of office space located at 177 East Colorado Blvd. for its corporate headquarters from 177 Colorado Owner, LLC, which lease expires on April 30, 2027. The lease contains an option to renew for one additional five-year term. The Company is not reasonably certain that it will exercise this option to renew and therefore it is not included in right-of-use assets and liabilities as of June 30, 2025.

**<u>San Diego, California</u>**: The Company leases 144,000 square feet of office and research and development laboratory space located at 10102 Hoyt Park from 11404 & 11408 Sorrento Valley Owner, LLC, which lease expires on April 30, 2038. Pursuant to the lease, within twelve months of the expiration of the initial 15-year term, the Company has the option to extend the lease for up to one additional ten-year term, with certain annual increases in base rent. The Company is not reasonably certain that it will exercise this option to renew and therefore it is not included in right-of-use assets and liabilities as of June 30, 2025.

The lease agreement, as amended, granted the Company the right to receive an Additional Tenant Improvement Allowance ("ATIA") funded by the lessor. The Company received $30.8 million in ATIA, including a final payment of $3.1 million during the first quarter of fiscal 2024. As a result, the Company remeasured its lease liability and right-of-use assets to reflect these additional allowances and the related increased lease payments. The Company has further concluded that these ATIAs have no effects on the classification of the lease.

**<u>Madison, Wisconsin</u>**: The Company leases 110,956 square feet space, which it increased from 107,000 square feet on June 30, 2025, located at 502 South Rosa Road for its office and laboratory facilities, which lease expires on September 30, 2031. The lease contains options to renew for two terms of five years. The Company is not reasonably certain that it will exercise this option and therefore it is not included in right-of-use assets and liabilities as of June 30, 2025.

The components of lease assets and liabilities along with their classification on the Company's consolidated balance sheets were as follows:

---

| | | | |
|:---|:---|:---|:---|
| **Lease Assets and Liabilities** | **Classification** | **June 30, 2025** | **September 30, 2024** |
| | | **(in thousands)** | **(in thousands)** |
| Operating lease assets | Right-of-use assets | $44002 | $45255 |
| Current operating lease liabilities | Lease liabilities | 7010 | 6342 |
| Non-current operating lease liabilities | Lease liabilities, net of current portion | 105690 | 111027 |

---

------

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | | **Three Months Ended June 30,** | **Three Months Ended June 30,** | **Nine Months Ended June 30,** | **Nine Months Ended June 30,** |
|<br>**Lease Cost** |<br>**Classification** | **2025** | **2024** | **2025** | **2024** |
|  |  | **(in thousands)** | **(in thousands)** | **(in thousands)** | **(in thousands)** |
| Operating lease cost | Research and development | $2233 | $2965 | $7754 | $8531 |
|  | General and administrative expense | 449 | 537 | 1442 | 1504 |
| Variable lease cost <sup>(1)</sup> | Research and development | 893 | 863 | 2830 | 2478 |
|  | General and administrative expense |  |  |  |  |
| Total |  | $3575 | $4365 | $12026 | $12513 |

---

*(1) Variable lease cost is primarily related to operating expenses associated with the Company's operating leases.*

There was no short-term lease cost during the three and nine months ended June 30, 2025 and 2024, respectively.

The following table presents maturities of operating lease liabilities on an undiscounted basis as of June 30, 2025:

---

| | |
|:---|:---|
| **Year** | **Amounts** |
| | **(in thousands)** |
| 2025 (remainder) | $3902 |
| 2026 | 15799 |
| 2027 | 14974 |
| 2028 | 13619 |
| 2029 | 13905 |
| 2030 and thereafter | 114790 |
| Total | $176989 |
| Less imputed interest | $(64289) |
| Total operating lease liabilities (includes current portion) | $112700 |

---

Supplemental cash flow and other information related to leases was as follows:

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended June 30,** | **Three Months Ended June 30,** | **Nine Months Ended June 30,** | **Nine Months Ended June 30,** |
| | **2025** | **2024** | **2025** | **2024** |
| | **(in thousands)** | **(in thousands)** | **(in thousands)** | **(in thousands)** |
| Cash received for amounts included in the measurement of lease liabilities: |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Operating cash flows from operating leases | $— | $— | $— | $3099 |
| Right-of-use assets obtained in exchange for amended operating lease liabilities | $— | $— | $— | $(64) |
| Cash paid for amounts included in the measurement of lease liabilities: |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Operating cash flows from operating leases | $3875 | $3204 | $11554 | $7221 |
|  |  |  | **June 30,** | **June 30,** |
|  |  |  | **2025** | **2024** |
| Weighted-average remaining lease term (in years) |  |  | 11.9 | 12.8 |
| Weighted-average discount rate |  |  | 8.0% | 8.0% |

---

------

**NOTE 9. STOCK-BASED COMPENSATION**

The Company has three plans that provide for equity-based compensation.

Under the 2013 Incentive Plan (the "2013 Plan"), 2,350,117 awards are granted and outstanding, relating to stock options and restricted stock awards to employees and directors as of June 30, 2025.

Under the 2021 Incentive Plan (the "2021 Plan"), 8,000,000 shares (subject to certain adjustments) of the Company's common stock are authorized for grants of stock options, stock appreciation rights, restricted and unrestricted stock, performance awards, cash awards and other awards convertible into or otherwise based on shares of the Company's common stock. The maximum number of shares authorized under the 2021 Plan will be (i) reduced by any shares subject to awards made under the 2013 Plan after January 1, 2021, and (ii) increased by any shares subject to outstanding awards under the 2013 Plan as of January 1, 2021 that, after January 1, 2021, are canceled, expired, forfeited or otherwise not issued under such awards (other than as a result of being tendered or withheld to pay the exercise price or withholding taxes in connection with any such awards) or settled in cash. As of June 30, 2025, 6,215,559 shares have been granted under the 2021 Plan. The total number of shares available for issuance was 2,308,495 shares, which includes 170,898 and 353,156 shares that were forfeited under the 2013 and 2021 Plans, respectively.

Under the Company's Inducement Plan (the "Inducement Plan"), 832,950 shares of the Company's common stock are authorized for issuance pursuant to grants of stock options, stock appreciation rights, restricted and unrestricted stock, stock units (including restricted stock units), performance awards, cash awards, and other awards convertible into or otherwise based on shares of the Company's common stock. Awards under the Inducement Plan may only be granted to new employees of the Company in accordance with the provisions of Rule 5635(c)(4) of the Nasdaq Listing Rules. As of June 30, 2025, 607,340 shares have been granted under the Inducement Plan. The total number of shares remaining available for issuance was 307,924 shares.

In addition, prior to adoption of the Inducement Plan, the Company previously granted stand-alone inducement awards in the form of stock options and restricted stock units outside of the Company's equity plans to new employees under Rule 5635(c)(4) of the Nasdaq Listing Rules. As of June 30, 2025, there were 602,355 and 138,775 shares underlying outstanding stand-alone inducement options and restricted stock units, respectively.

The following table presents a summary of awards outstanding attributable to Arrowhead Pharmaceuticals, Inc.:

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **June 30, 2025** | **June 30, 2025** | **June 30, 2025** | **June 30, 2025** |
| | **2013 Plan** | **2021 Plan** | **Inducement Awards** | **Total** |
| **Granted and outstanding awards:** | | | | |
| &nbsp;&nbsp;Options | 850117 | 32151 | 602355 | 1484623 |
| &nbsp;&nbsp;Restricted stock units | 1500000 | 3888660 | 592262 | 5980922 |
| &nbsp;&nbsp;&nbsp;&nbsp;**Total** | 2350117 | 3920811 | 1194617 | 7465545 |

---

The following table summarizes stock-based compensation expenses included in operating expenses attributable to Arrowhead Pharmaceuticals, Inc.:

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended June 30,** | **Three Months Ended June 30,** | **Nine Months Ended June 30,** | **Nine Months Ended June 30,** |
| | **2025** | **2024** | **2025** | **2024** |
| | **(in thousands)** | **(in thousands)** | **(in thousands)** | **(in thousands)** |
| Research and development | $6898 | $6221 | $21008 | $21634 |
| General and administrative | 5095 | 8490 | 20242 | 27350 |
| Total | $11993 | $14711 | $41250 | $48984 |

---

***Stock Option Awards***

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following table presents a summary of the stock option activity for the nine months ended June 30, 2025:

------

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Shares** | **Weighted-<br>Average<br>Exercise<br>Price<br>Per Share** | **Weighted-<br>Average<br>Remaining<br>Contractual<br>Term (Years)** | **Aggregate<br>Intrinsic<br>Value** |
| Outstanding at September 30, 2024 | 1978516 | $23.39 |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Granted |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Cancelled or expired | (35341) | 45.92 |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Exercised | (458552) | 7.55 |  |  |
| Outstanding at June 30, 2025 | 1484623 | $27.75 | 3.5 | $5750674 |
| Exercisable at June 30, 2025 | 1484623 | $27.75 | 3.5 | $5750674 |

---

The aggregate intrinsic values represent the amount by which the market price of the underlying stock exceeds the exercise price of the option. The total intrinsic value of the options exercised during the three months ended June 30, 2025 and 2024 was $0.3 million and $0.7 million, respectively. The total intrinsic value of the options exercised during the nine months ended June 30, 2025 and 2024 was $4.9 million and $3.8 million, respectively.

For the three months ended June 30, 2025, there was no stock-based compensation expense related to stock options outstanding, while $0.4 million was recorded for the same period in 2024. Stock-based compensation expense related to stock options outstanding for the nine months ended June 30, 2025 and 2024, was $0.1 million and $2.5 million, respectively.

As of June 30, 2025, the pre-tax compensation expense for all outstanding unvested stock options is considered nominal.

The fair value of each stock option award is estimated on the date of grant using the Black-Scholes option pricing model. The Black-Scholes option pricing model was developed for use in estimating the fair value of traded options, which do not have vesting restrictions and are fully transferable. The determination of the fair value of each stock option is affected by the Company's stock price on the date of grant, as well as assumptions regarding a number of highly complex and subjective variables. No options were granted during the nine months ended June 30, 2025 and 2024.

**<u>Visirna ESOP</u>**: On October 1, 2023, Visirna, a subsidiary of the Company, granted 7,500,000 stock options to its employees from the Employee Stock Option Plan (the "Visirna ESOP"), which authorizes 20,000,000 shares for issuance. The Visirna ESOP is independently managed by Visirna, including the valuation process. For the three months ended June 30, 2025 and 2024, stock-based compensation expense related to the Visirna ESOP was $1.1 million and $2.3 million, respectively. For the nine months ended June 30, 2025 and 2024, stock-based compensation expense related to the Visirna ESOP was $3.0 million and $5.5 million, respectively.

***Restricted Stock Units***

Restricted Stock Units ("RSUs"), including market-based, time-based and performance-based awards, have been granted under the Company's 2013 and 2021 Plans, the Inducement Plan, and as inducements awards granted outside of the Company's equity-based compensation plans. At vesting, each outstanding RSU will be exchanged for one share of the Company's common stock. RSU awards generally vest subject to the satisfaction of service requirements or the satisfaction of both service requirements and achievement of certain performance targets.

The following table summarizes the activity of the Company's RSUs:

---

| | | |
|:---|:---|:---|
| | **Number of<br>RSUs** | **Weighted-<br>Average<br>Grant<br>Date<br>Fair Value<br>Per Share** |
| Outstanding at September 30, 2024 | 4913312 | $49.61 |
| &nbsp;&nbsp;&nbsp;&nbsp;Granted | 2711009 | 19.49 |
| &nbsp;&nbsp;&nbsp;&nbsp;Vested | (1383568) | 43.96 |
| &nbsp;&nbsp;&nbsp;&nbsp;Forfeited | (259831) | 32.96 |
| Outstanding at June 30, 2025 | 5980922 | $37.97 |

---

------

The fair value of RSUs was determined based on the closing price of the Company's common stock on the grant date, with consideration given to the probability of achieving service and/or performance conditions for awards.

For the three months ended June 30, 2025 and 2024, the Company recorded $11.9 million and $14.3 million of expense related to RSUs, respectively. For the nine months ended June 30, 2025 and 2024, the Company recorded $41.1 million and $46.5 million of expense related to RSUs, respectively. As of June 30, 2025, there was $85.8 million of total unrecognized compensation cost related to RSUs that is expected to be recognized over a weighted-average period of 1.7 years.

------

**NOTE 10. FAIR VALUE MEASUREMENTS**

The Company employs a fair value hierarchy that prioritizes the inputs to valuation techniques used to measure fair value. The Company's valuation techniques and inputs used to measure fair value and the definition of the three levels (Level 1, Level 2, and Level 3) of the fair value hierarchy are disclosed in Note 10 - Fair Value Measurements of Notes to Consolidated Financial Statements of Part IV, "Item 15. Exhibits and Financial Statement Schedules" of its Annual Report on Form 10-K for the fiscal year ended September 30, 2024.

The Company uses prices and inputs that are current as of the measurement date, including during periods of market disruption. In periods of market disruption, the ability to observe prices and inputs may be reduced for many instruments. This condition could cause an instrument to be reclassified from Level 1 to Level 2, or from Level 2 to Level 3. The Company recognizes transfers between levels at either the actual date of the event or a change in circumstances that caused the transfer. As of June 30, 2025 and September 30, 2024, the Company did not have any financial assets or financial liabilities based on Level 3 measurements.

The following tables present information about the Company's assets and liabilities measured at fair value on a recurring basis, and indicates the fair value hierarchy of the valuation techniques utilized by the Company:

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **June 30, 2025** | **June 30, 2025** | **June 30, 2025** | **June 30, 2025** |
| | **Level 1** | **Level 2** | **Level 3** | **Total** |
| | **(in thousands)** | **(in thousands)** | **(in thousands)** | **(in thousands)** |
| **Available-for-sale securities** | | | | |
| &nbsp;&nbsp;&nbsp;&nbsp;U.S. government and agency securities | $— | $221877 | $— | $221877 |
| &nbsp;&nbsp;&nbsp;&nbsp;Municipal securities |  | 7019 |  | 7019 |
| &nbsp;&nbsp;&nbsp;&nbsp;Commercial notes |  | 26449 |  | 26449 |
| &nbsp;&nbsp;&nbsp;&nbsp;Corporate debt securities |  | 515234 |  | 515234 |
| **Total available-for-sale securities** |  | 770579 |  | 770579 |
| **Cash equivalents** |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Money market instruments | 81283 |  |  | 81283 |
| &nbsp;&nbsp;&nbsp;&nbsp;Term deposit |  | 11049 |  | 11049 |
| &nbsp;&nbsp;&nbsp;&nbsp;U.S. Treasuries |  | 7960 |  | 7960 |
| &nbsp;&nbsp;&nbsp;&nbsp;Commercial notes |  | 23770 |  | 23770 |
| **Total cash equivalents** | 81283 | 42779 |  | 124062 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**Total financial assets** | $81283 | $813358 | $— | $894641 |

---

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| | | | | |
|:---|:---|:---|:---|:---|
| | **September 30, 2024** | **September 30, 2024** | **September 30, 2024** | **September 30, 2024** |
| | **Level 1** | **Level 2** | **Level 3** | **Total** |
| | **(in thousands)** | **(in thousands)** | **(in thousands)** | **(in thousands)** |
| **Available-for-sale securities** | | | | |
| &nbsp;&nbsp;&nbsp;&nbsp;U.S. government and agency securities | $— | $160723 | $— | $160723 |
| &nbsp;&nbsp;&nbsp;&nbsp;Commercial notes |  | 179714 |  | 179714 |
| &nbsp;&nbsp;&nbsp;&nbsp;Corporate debt securities |  | 237839 |  | 237839 |
| **Total available-for-sale securities** |  | 578276 |  | 578276 |
| **Cash equivalents** |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Money market instruments | 66966 |  |  | 66966 |
| **Total cash equivalents** | 66966 |  |  | 66966 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**Total financial assets** | $66966 | $578276 | $— | $645242 |

---

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**NOTE 11. LIABILITY RELATED TO THE SALE OF FUTURE ROYALTIES**

In November 2022, the Company and Royalty Pharma entered into the Royalty Pharma Agreement, pursuant to which Royalty Pharma agreed to pay up to $410.0 million in cash to the Company in consideration for the Company's future royalty interest in olpasiran, originally developed by the Company and licensed to Amgen in September 2016 under the Olpasiran Agreement.

Pursuant to the Royalty Pharma Agreement, Royalty Pharma paid $250.0 million upfront and agreed to pay up to an additional $160.0 million in aggregate one-time milestone payments due if and when the following milestone events occur: (i) $50.0 million on completion of enrollment in the OCEAN Phase 3 clinical trial for olpasiran, (ii) $50.0 million upon receipt of FDA approval of olpasiran for an approved indication (reduction in the risk of myocardial infarction, urgent coronary revascularization, or coronary heart disease death in adults with established cardiovascular disease and elevated Lp(a)), and (iii) $60.0 million upon Royalty Pharma's receipt of at least $70.0 million of royalty payments under the Royalty Pharma Agreement in any single calendar year. During the third quarter of fiscal 2024, Amgen completed enrollment of the Phase 3 OCEAN(a) outcomes trial of olpasiran, which triggered a $50.0 million milestone payment that the Company received in the same quarter.

In consideration for the payment of the foregoing amounts under the Royalty Pharma Agreement, Royalty Pharma is entitled to receive all royalties otherwise payable by Amgen to the Company under the Olpasiran Agreement. The Company remains eligible to receive any milestone payments potentially payable by Amgen under the Olpasiran Agreement.

The Company has evaluated the terms of the Royalty Pharma Agreement and concluded, in accordance with the relevant accounting guidance, that the Company accounted for the transaction as debt and the funding of $250.0 million and $50.0 million from Royalty Pharma were recorded as liabilities related to the sale of future royalties on its consolidated balance sheets. The Company is not obligated to repay these funds received under the Royalty Pharma Agreement.

The Company records the obligations at their carrying value using the effective interest method. In order to amortize the sale of future royalties, the Company utilizes the prospective method to estimate the future royalties to be paid by the Company to the counterparty over the life of the arrangement. Under the prospective method, a new effective interest rate is determined based on the revised estimate of remaining cash flows. The new rate is the discount rate that equates the present value of the revised estimate of remaining cash flows with the carrying amount of the debt, and it will be used to recognize non-cash interest expense for the remaining periods. The Company periodically assesses the amount and the timing of expected royalty payments using a combination of internal projections and forecasts from external sources. The estimates of future net product sales (and resulting royalty payments) are based on key assumptions including population, penetration, probability of success and sales price, among others. To the extent such payments are greater or less than the Company's initial estimates or the timing of such payments is different than its original estimates, the Company will prospectively adjust the amortization of the royalty financing obligations and the effective interest rate. As of June 30, 2025, the estimated effective interest rate was 9.1%.

The following table presents the activity with respect to the liability related to the sale of future royalties.

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| | | |
|:---|:---|:---|
| | **June 30, 2025** | **September 30, 2024** |
| | **(in thousands)** | **(in thousands)** |
| Beginning carrying value | $341361 | $268326 |
| Milestone payment received |  | 50000 |
| Non-cash interest expense recognized | 18893 | 23035 |
| Ending carrying value | $360254 | $341361 |

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**NOTE 12. FINANCING AGREEMENT** 

On August 7, 2024 (the "Closing Date"), the Company entered into a Financing Agreement with the guarantors party thereto, the lenders party thereto (the "Lenders"), and Sixth Street Lending Partners ("Sixth Street"), as the administrative agent and collateral agent for the Lenders (the "Financing Agreement"). The Financing Agreement establishes a senior secured term loan facility of $500.0 million (the "Credit Facility"), consisting of $400.0 million funded on the Closing Date and an additional $100.0 million available at the Company's option, subject to mutual agreement with Sixth Street. The loans under the Credit Facility bear interest at an annual rate of 15.0%, which is paid in kind and added to the outstanding principal balance of the Credit Facility each period. The outstanding principal balance of this Credit Facility, including amounts representing accrued but unpaid interest previously paid in kind, is due and payable on August

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7, 2031.

The Company is permitted to use the net proceeds for working capital, capital expenditures and general corporate purposes of the Company and its subsidiaries.

The Company will have the right to prepay loans under the Credit Facility at any time. The Company is required to partially repay loans under the Credit Facility with proceeds from certain asset sales, condemnation events and extraordinary receipts, subject, in some cases, to reinvestment rights. If the Company repays in full the aggregate principal outstanding under the Credit Facility and such payment in full occurs on or prior to August 7, 2028, the Company will be required to make an additional payment to the lenders under the Credit Facility on such date in an amount necessary for the lenders to achieve a two times multiple of invested capital ("MOIC") of the aggregate principal amount funded on the Closing Date (the "MOIC Payment"). If such payment in full occurs after August 7, 2028, the Company will be required to make a payment to the lenders under the Credit Facility on such date in an amount necessary for the lenders to achieve the greater of the MOIC Payment and the present value of all interest payments that would have been payable from such date through the maturity date of the Credit Facility discounted at the Treasury Rate (as defined in the Financing Agreement) plus 0.5%; provided that such payment amount in this instance will not exceed the amount necessary for the lenders to achieve a 2.5 times MOIC.

On November 26, 2024, the Company entered into an amendment to the Financing Agreement (the "Amendment") to modify, amongst other things, some of the prepayment terms of the loans under the Credit Facility, including, the prepayment terms related to the Sarepta Collaboration Agreement. The Amendment was effective on February 14, 2025, following the closing of the Sarepta Collaboration Agreement and receipt of the $500.0 million upfront payment from Sarepta. The Amendment added an additional prepayment clause that requires certain contractual prepayments of principle and MOIC payments throughout the life of the loans under the Credit Facility. Additionally, any prepayment will be split with 50% of any such prepayment paying down the principle balance of the loans under the Credit Facility and the other 50% being applied to prepay the MOIC Payment. In the event the prepayment amounts result in fees being prepaid in excess of the actual amounts required to be paid, the excess fees shall be reallocated and applied to reduce the amount of the principal balance upon repayment in full of the loans under the Credit Facility. As of June 30, 2025, the Company has paid $100.0 million in MOIC payments of which $25.3 million is expected to be applied to principal upon repayment in full.

To date, the Company has paid $201.6 million of the loans under the Credit Facility during fiscal 2025.

The Amendment was accounted for as a debt modification under ASC 470-50, *"Debt—Modification and extinguishments*" since the Amendment did not result in substantially different terms. In connection with the Amendment, the Company did not incur significant third-party fees.

All obligations under the Financing Agreement are secured on a first-priority basis by security interests in substantially all assets of the Company and material subsidiaries of the Company, including its intellectual property, subject to certain exceptions, and is guaranteed by material subsidiaries of the Company, including foreign subsidiaries, subject to certain exceptions.

The Financing Agreement contains customary covenants, including, without limitation, a financial covenant to maintain liquidity (cash, cash equivalents and investments) of at least $100.0 million if the Company's market capitalization is above $1.5 billion, and negative covenants that, subject to certain exceptions, restrict indebtedness, liens, investments (including acquisitions), fundamental changes, asset sales and licensing transactions, dividends, modifications to material agreements, payment of subordinated indebtedness, distributions from certain parties, and other matters customarily restricted in such agreements. The Company is subject to restrictions on sales and licensing transactions with respect to certain core intellectual property, subject to certain exceptions, including certain transactions related to areas outside the United States, United Kingdom, European Union, Japan and China.

The Financing Agreement contains certain embedded features that were identified and evaluated as not material to the consolidated financial statements.

The outstanding balance of the Credit Facility consisted of the following:

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---

| | | |
|:---|:---|:---|
| | **June 30, 2025** | **September 30, 2024** |
| | **(in thousands)** | **(in thousands)** |
| Initial Term Loan | $400000 | $400000 |
| Accumulated interest on the Initial Term Loan | 53454 | 9000 |
| Accumulated accretion of the MOIC Payment | 2787 |  |
| Less: Unamortized debt issuance costs | (14284) | (15817) |
| Less: Current portion of credit facility | (40000) |  |
| Less: Payments | (201625) |  |
| &nbsp;&nbsp;Credit facility, net of current portion | $200332 | $393183 |

---

The following table sets forth total interest expense recognized related to the Credit Facility:

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| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended June 30,** | **Three Months Ended June 30,** | **Nine Months Ended June 30,** | **Nine Months Ended June 30,** |
| | **2025** | **2024** | **2025** | **2024** |
| | **(in thousands)** | **(in thousands)** | **(in thousands)** | **(in thousands)** |
| Amortization of debt issuance costs | $420 | $— | $1533 | $— |
| Accretion of the MOIC Payment | 2218 |  | 2787 |  |
| Contractual interest expense | 13766 |  | 44454 |  |
| &nbsp;&nbsp; Total interest expense | $16404 | $— | $48774 | $— |

---

The amounts shown in the table below, related to the Credit Facility, represent the expected repayments of principle and accrued interest balance as of June 30, 2025 as well as any mandatory prepayments that the Company is obligated to make to the Lenders during the indicated periods. The principal balance will increase from accrued paid in kind interest and the table does not include MOIC payments beyond those contractually determined. Actual payments on current principal may vary from the amounts presented in the table.

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| | |
|:---|:---|
| **Year** | **Amounts** |
| | **(in thousands)** |
| 2025 (remainder) | $— |
| 2026 | 40000 |
| 2027 | 40000 |
| 2028 | 15000 |
| 2029 | 15000 |
| Thereafter | 216503 |
| Total | $326503 |

---

In May 2025, Visirna entered into the Revolving Credit Agreement with Bank of Zhejiang. The maximum aggregate credit facility is 73.0 million Chinese Yuan ($10.0 million) bearing an annual interest rate of 4.1%. The term of each loan is twelve months. The amount outstanding as of June 30, 2025 was 50.8 million Chinese Yuan ($7.1 million) on the credit facility which was classified as other current liabilities.

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**NOTE 13. NET (LOSS) INCOME PER SHARE**

The following table presents the computation of basic and diluted net (loss) income per share for the three and nine months ended June 30, 2025 and 2024.

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| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended June 30,** | **Three Months Ended June 30,** | **Nine Months Ended June 30,** | **Nine Months Ended June 30,** |
| | **2025** | **2024** | **2025** | **2024** |
| | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**(in thousands, except per share amounts)** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**(in thousands, except per share amounts)** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**(in thousands, except per share amounts)** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**(in thousands, except per share amounts)** |
| **Numerator:** |  |  |  |  |
| &nbsp;&nbsp;Net (loss) income attributable to Arrowhead Pharmaceuticals, Inc. | $(175241) | $(170793) | $22119 | $(428957) |
| **Denominator:** |  |  |  |  |
| &nbsp;&nbsp;Weighted-average basic shares outstanding <sup>(1)</sup> | 139039 | 124199 | 132385 | 118260 |
| &nbsp;&nbsp;Effect of dilutive securities |  |  | 967 |  |
| &nbsp;&nbsp;Weighted-average diluted shares outstanding <sup>(1)</sup> | 139039 | 124199 | 133352 | 118260 |
| Basic net (loss) income per share | $(1.26) | $(1.38) | $0.17 | $(3.63) |
| Diluted net (loss) income per share | $(1.26) | $(1.38) | $0.17 | $(3.63) |

---

*(1) Includes shares of common stock into which the Avoro Pre-Funded Warrants may be exercised. See Note 6.*

The following table sets forth the potentially dilutive securities that have been excluded from the calculation of diluted net (loss) income per share because to include them would be anti-dilutive.

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| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended June 30,** | **Three Months Ended June 30,** | **Nine Months Ended June 30,** | **Nine Months Ended June 30,** |
| | **2025** | **2024** | **2025** | **2024** |
| | **(in thousands)** | **(in thousands)** | **(in thousands)** | **(in thousands)** |
| Options | 768 | 753 | 756 | 711 |
| Restricted stock units | 5178 | 3976 | 4770 | 4060 |
| Total | 5946 | 4729 | 5526 | 4771 |

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**NOTE 14. INCOME TAXES**

The Company's estimated annual effective tax rate significantly fluctuates for fiscal 2025 with small changes to the Company's estimated income. For the three months ended June 30, 2025, the Company has recorded a discrete income tax benefit of $0.4 million. The income tax provision for the three months ended June 30, 2024, resulted in no tax expense. For the nine months ended June 30, 2025, the Company has recorded a discrete income tax expense of $1.4 million, and for the nine months ended June 30, 2024, the Company has recorded a discrete income tax benefit of $3.3 million. Income tax expense for the three and nine months ended June 30, 2025 was based on actual year to date income recorded and statutory tax rates.

The Company does not anticipate any changes in its unrecognized tax benefits over the next 12 months. Due to the presence of net operating loss carryforwards, all of the income tax years remain open for examination domestically. The Company has not been notified that it is under audit by the Internal Revenue Service or foreign taxing authorities; however, the Company has been notified of an income tax examination by the State of California. There are no other audits in any other jurisdictions.

**NOTE 15. SUBSEQUENT EVENTS *Visirna***

On August 1, 2025, Visirna Therapeutics HK Limited ("Visirna HK"), a wholly owned subsidiary of Visirna Therapeutics, Inc, a majority owned subsidiary of the Company, entered into an Asset Purchase Agreement (the "Asset Purchase Agreement") with Genzyme Corporation ("Sanofi"), a wholly owned subsidiary of Sanofi S.A., pursuant to which Visirna HK sold all of its assets and rights in investigational plozasiran to Sanofi, which included an assignment of Visirna HK's rights (as successor by assignment from Visirna) to develop and commercialize investigational plozasiran in Greater China pursuant to that certain License Agreement by and between the Company and Visirna dated, April 25, 2022 (the "Visirna License Agreement"). The Asset Purchase Agreement is scheduled to close during the second half of the

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year.

In connection with the Asset Purchase Agreement, the Company consented to the partial assignment of the Visirna License Agreement by Visirna HK to Sanofi (as so assigned, the "Sanofi License Agreement"), amongst other agreements between the Company and Visirna, effective as of the closing of the Asset Purchase Agreement. After giving effect to the Asset Purchase Agreement, Visirna HK retains rights to develop and commercialize in Greater China three other cardiometabolic drugs licensed to it pursuant to the Visirna License Agreement.

Upon closing of the Asset Purchase Agreement, Visirna will receive an upfront payment of $130.0 million from Sanofi and is eligible to receive further milestone payments of up to $265.0 million upon approval of plozasiran across various indications in mainland China. The Company is also eligible to receive royalties from Sanofi on net commercial product sales in Greater China under the Sanofi License Agreement.

***Sarepta DM1 Milestone***

On July 27, 2025, the Company triggered a $100.0 million milestone payment from Sarepta. The Company reached the first of two prespecified enrollment targets and subsequent authorization to dose escalate in a Phase 1/2 clinical study of ARO-DM1, an investigational RNAi therapeutic for treatment of type 1 myotonic dystrophy (DM1), as outlined in the Sarepta Collaboration Agreement, triggering the milestone. The Company is eligible to receive up to an additional $200.0 million in near-term milestone payments associated with the continued enrollment of certain cohorts of a Phase 1/2 study of ARO-DM1.

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**ITEM 2.&nbsp;&nbsp;&nbsp;&nbsp;MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS** 

**FORWARD-LOOKING STATEMENTS**

*This Quarterly Report on Form 10-Q contains certain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and we intend that such forward-looking statements be subject to the safe harbors created thereby. For this purpose, any statements contained in this Quarterly Report on Form 10-Q except for historical information may be deemed to be forward-looking statements. Without limiting the generality of the foregoing, words such as "may," "might," "will," "expect," "believe," "anticipate," "goal," "endeavor," "strive," "intend," "plan," "project," "could," "estimate," "target," "might," "forecast," "potential," or "continue" or the negative of these words or other variations thereof or comparable terminology are intended to identify forward-looking statements. In addition, any statements that refer to projections of our future financial performance, trends in our business, or other characterizations of future events or circumstances are forward-looking statements. These forward-looking statements include, but are not limited to, statements about the initiation, timing, progress and results of our preclinical studies and clinical trials, and our research and development programs, our expectations regarding regulatory approval for and commercial launch of plozasiran; our expectations regarding the potential benefits of the partnership, licensing and/or collaboration arrangements and other strategic arrangements and transactions we have entered into or may enter into in the future; our beliefs and expectations regarding the amount and timing of future milestone, royalty or other payments that could be due to or from third parties under existing agreements; and our estimates regarding future revenues, research and development expenses, capital requirements and payments to third parties.*

*The forward-looking statements included herein are based on current expectations of our management based on available information and involve a number of risks and uncertainties, all of which are difficult or impossible to predict accurately, and many of which are beyond our control. As such, our actual results or outcomes and timing of certain events may differ materially from those discussed, projected, anticipated or indicated in any forward-looking statements. Forward-looking statements are not guarantees of future performance and our actual results of operations, financial condition and cash flows may differ materially. Factors that may cause or contribute to such differences include, but are not limited to, those discussed in more detail in "Item 2. Management's Discussion and Analysis of Financial Condition and Results of Operations" of Part I and "Item 1A. Risk Factors" of Part II of this Quarterly Report on Form 10-Q as well as "Item 1. Business" and* "*Item 1A. Risk Factors" of Part I and "Item 7. Management's Discussion and Analysis of Financial Condition and Results of Operations" of Part II of our most recent Annual Report on Form 10-K. Readers should carefully review these risks, as well as the additional risks described in other documents we file from time to time with the Securities and Exchange Commission (the "SEC"). In light of the significant risks and uncertainties inherent in the forward-looking information included herein, the inclusion of such information should not be regarded as a representation by us or any other person that such results will be achieved, and readers are cautioned not to place undue reliance on such forward-looking information. Statements made herein are as of the date of the filing of this Quarterly Report on Form 10-Q with the SEC and should not be relied upon as of any subsequent date. Except as may be required by law, we disclaim any intent to revise the forward-looking statements contained herein to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events.*

**OVERVIEW**

The Company develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, the Company's therapies trigger the RNAi interference mechanism to induce rapid, deep and durable knockdown of target genes. RNAi is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. RNAi-based therapeutics may leverage this natural pathway of gene silencing to target and shut down specific disease-causing genes.

The Company believes that TRiM<sup>TM</sup> enabled therapeutics offer several potential advantages over prior generations and competing technologies, including: simplified manufacturing and reduced costs; multiple routes of administration including subcutaneous injection and inhaled administration; the ability to target multiple tissue types including liver, lung, central nervous system (CNS), muscle, and adipose tissue; and the potential for improved safety and reduced risk of intracellular buildup, because there are fewer metabolites from smaller, simpler molecules.

The Company's pipeline includes:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Hypertriglyceridemia - plozasiran (formerly ARO-APOC3);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Homozygous familial hypercholesterolemia (HoFH) - zodasiran (formerly ARO-ANG3);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Cardiovascular disease - olpasiran (formerly AMG 890 or ARO-LPA, out-licensed to Amgen);

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Inflammatory pulmonary conditions - ARO-RAGE;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Idiopathic pulmonary fibrosis - SRP-1002 (formerly ARO-MMP7, out-licensed to Sarepta);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Metabolic-dysfunction associated steatohepatitis (MASH) - GSK-4532990 (formerly ARO-HSD, out

licensed to GSK);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Alpha-1 antitrypsin deficiency (AATD) - fazirsiran (formerly ARO-AAT, a collaboration with Takeda);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Chronic Hepatitis B virus - daplusiran/tomligisiran - GSK5637608 (formerly JNJ-3989 and ARO-HBV, out-licensed to GSK);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Complement mediated diseases - ARO-C3 and ARO-CFB;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Metabolic-dysfunction associated steatohepatitis (MASH) - ARO-PNPLA3 (formerly JNJ-75220795 or ARO-JNJ1);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Obesity - ARO-INHBE and ARO- ALK7

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Facioscapulohumeral muscular dystrophy - SRP-1001 (formerly ARO-DUX4, out-licensed to Sarepta);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Myotonic Dystrophy Type 1 - SRP1003 (formerly ARO-DM1 out-licensed to Sarepta; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Spinocerebellar ataxia 2 - SRP-1004 (formerly ARO-ATXN2, out-licensed to Sarepta).

The Company operates lab facilities in California and Wisconsin, where its research and development activities, including the development of RNAi therapeutics, take place. The Company's principal executive offices are located in Pasadena, California.

The Company continues to develop other clinical candidates for future clinical trials. Clinical candidates are tested internally and through Good Laboratory Practice (GLP) toxicology studies at outside laboratories. Drug materials for such studies and clinical trials are either manufactured internally or contracted to third-party manufacturers. The Company engages third-party contract research organizations (CROs) to manage clinical trials and works cooperatively with such organizations on all aspects of clinical trial management, including plan design, patient recruiting, and follow up. These outside costs, including toxicology/efficacy testing and manufacturing costs, as well as the preparation for and administration of clinical trials, are referred to as "candidate costs." As clinical candidates progress through clinical development, candidate costs will increase.

***The First Three Quarters of Fiscal 2025 Business Highlights***

Key recent developments through the first three quarters of fiscal 2025 included the following:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Triggered a $100.0 million milestone payment from Sarepta Therapeutics, Inc., which was triggered on July 27, 2025, when the Company reached the first of two prespecified enrollment targets and subsequent authorization to dose escalate in a Phase 1/2 clinical study of ARO-DM1, an investigational RNAi therapeutic for the treatment of type 1 myotonic dystrophy (DM1);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Announced the signing of an asset purchase agreement between Sanofi and Visirna Therapeutics, a majority-owned subsidiary of the Company, created to develop and commercialize four of the Company's investigational cardiometabolic candidates in Greater China. Under the terms of the agreement, Sanofi will acquire rights to develop and commercialize investigational plozasiran, the Company's first-in-class RNAi therapeutic candidate designed to reduce production of apolipoprotein C-III (APOC3) as a potential treatment for familial chylomicronemia syndrome (FCS) and severe hypertriglyceridemia (SHTG), in Greater China;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Initiated and dosed the first subject in the YOSEMITE Phase 3 clinical trial of zodasiran, the Company's investigational RNAi therapeutic being developed as a potential treatment for homozygous familial hypercholesterolemia (HoFH), a rare genetic condition that leads to severely elevated LDL-cholesterol and early onset cardiovascular disease;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Completed enrollment of SHASTA-3, SHASTA-4, and MUIR-3 Phase 3 clinical trials of plozasiran. The Company's global Phase 3 clinical studies are designed to support regulatory submissions for approval of investigational plozasiran in the treatment of severe hypertriglyceridemia. The Company previously submitted a New Drug Application to the U.S. Food and Drug Administration ("FDA") on November 16, 2024 for plozasiran based on positive Phase 3 PALISADE study results in patients with familial chylomicronemia syndrome, which the FDA accepted on January 17, 2025, with a Prescription Drug User Fee Act (PDUFA) action date of November 18, 2025, and indicated it is not currently planning to hold an advisory committee meeting;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Initiated a Phase 1/2a clinical trial of ARO-ALK7 for the treatment of obesity. ARO-ALK7 is the first RNAi-based therapy designed to silence adipocyte expression of the *ACVR1C* gene to reduce the production of Activin receptor-like kinase 7 (ALK7), which acts as a receptor in a pathway that regulates energy homeostasis in adipose tissue;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Announced Topline results from Part 2 of a Phase 1/2 clinical study of ARO-C3, the Company's investigational RNAi therapeutic designed to reduce liver production of complement component 3 (C3) as a potential therapy for various complement mediated diseases. ARO-C3 achieved reductions in alternative pathway complement activity and proteinuria;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Entered into a global licensing and collaboration agreement with Sarepta on November 25, 2024, which closed on February 7, 2025. Closing of the transaction was subject to the expiration or termination of the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976 and other customary conditions. Upon closing, the Company received $325.0 million through the purchase of 11,926,301 shares of Company common stock by Sarepta, at a price per share of $27.25, and received $500.0 million as an upfront payment on February 24, 2025. The Company will also receive $250.0 million to be paid in equal installments over five years and is eligible to receive an additional $300.0 million in near-term payments. Additionally, the Company is eligible to receive royalties on commercial sales and up to approximately $10.0 billion in future potential milestone payments;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• GSK dosed its fifth patient in a Phase 2 trial in December 2024, triggering a $2.5 million milestone payment to the Company which was paid in the second quarter of fiscal 2025;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;***•*** Announced that the Company dosed the first subjects in a Phase 1/2a clinical trial of ARO-INHBE; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Presented interim results from a Phase 1/2a clinical study of ARO-CFB at the 8th Complement-Based Drug Development Summit. The study resulted in multiple findings including: (1) ARO-CFB led to dose dependent reductions in circulating CFB protein by up to 90% with greater than 3 months duration, (2) single and multiple doses of ARO-CFB led to near complete inhibition of alternative pathway activity based on Wieslab AP, and (3) single and multiple doses of ARO-CFB led to near complete inhibition of alternative pathway hemolytic activity, measured by AH50.

***Critical Accounting Estimates***

There have been no significant changes to the Company's critical accounting estimates disclosed in the most recent Annual Report on Form 10-K for the fiscal year ended September 30, 2024.

**RESULTS OF OPERATIONS**

The following data summarizes the Company's results of operations for the following periods indicated:

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| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended June 30,** | **Three Months Ended June 30,** | **Nine Months Ended June 30,** | **Nine Months Ended June 30,** |
| | **2025** | **2024** | **2025** | **2024** |
| | **(in thousands, except per share amounts)** | **(in thousands, except per share amounts)** | **(in thousands, except per share amounts)** | **(in thousands, except per share amounts)** |
| Revenue | $27767 | $— | $572976 | $3551 |
| Operating (loss) income | $(165550) | $(176141) | $54240 | $(438877) |
| Net (loss) income attributable to Arrowhead | $(175241) | $(170793) | $22119 | $(428957) |
| Net (loss) income per diluted share attributable to Arrowhead | $(1.26) | $(1.38) | $0.17 | $(3.63) |

---

**<u>Revenue</u>**

Total revenue for the three and nine months ended June 30, 2025 increased by $27.8 million and $569.4 million, respectively, from the same periods of 2024. The change was primarily driven by the revenue recognition associated with GSK and Sarepta license agreements as discussed below.

The Company has evaluated each agreement in accordance with FASB Topic 808–*Collaborative Arrangements* and Topic 606-*Revenue for Contracts from Customers*. See Note 2 — Collaboration and License Agreements of the Notes to Consolidated Financial Statements of Part I, "Item 1. Financial Statements" for more information on revenue recognized under the collaboration and license agreements.

------

**Takeda**: In October 2020, Takeda and the Company entered into the Takeda License Agreement. The Company has allocated the total $300.0 million initial transaction price to its one distinct performance obligation for the fazirsiran license and the associated Takeda R&D Services. Revenue was recognized using the input method (based on actual patient visits completed versus total estimated visits completed for the ongoing SEQUOIA and AROAAT2002 clinical studies). The Phase 2 study visits for patients in the SEQUOIA and AROAAT2002 studies concluded by December 31, 2023, and the Company has substantially completed its performance obligation under the Takeda License Agreement. As such, all revenue has been fully recognized as of December 31, 2023. During the nine months ended June 30, 2024, the Company recorded $0.9 million revenue.

**GSK**: On December 11, 2023, the Company entered into the GSK-HBV Agreement pursuant to which GSK received a worldwide, exclusive license to develop and commercialize daplusiran/tomligisiran (GSK5637608, formerly JNJ-3989), the Company's third-generation subcutaneously administered RNAi therapeutic candidate being developed as a potential therapy for patients with chronic hepatitis B virus infection.

Under the terms of the GSK-HBV Agreement, the Company received $2.7 million in December 2023, upon signing the GSK-HBV Agreement. Further, GSK dosed the fifth patient in a Phase 2 trial in December 2024, triggering a $2.5 million milestone payment to the Company which was paid in the second quarter of fiscal 2025. During the nine months ended June 30, 2025, the Company recorded $2.6 million revenue.

**Sarepta**: On November 25, 2024, the Company entered into the Sarepta Collaboration Agreement and Stock Purchase Agreement with Sarepta for the development and commercialization of multiple clinical and preclinical programs in rare, genetic diseases of the muscle, central nervous system, and lungs. During the nine months ended June 30, 2025, the Company recorded $570.3 million in revenue. As of June 30, 2025, no revenue was recorded for the milestone payments or royalties, as none had been achieved.

------

**<u>Operating Expenses</u>**

The analysis below details the operating expenses and discusses the expenditures of the Company within the major expense categories. For purposes of comparison, the amounts for the three and nine months ended June 30, 2025 and 2024 are shown in the tables below.

***Research and Development ("R&D") Expenses***

Research and development expenses are related to the Company's research and development discovery efforts and related candidate costs, which are comprised primarily of outsourced costs related to the manufacturing of clinical supplies, toxicity/efficacy studies and clinical trial expenses. Internal costs primarily relate to discovery operations at the Company's research facilities in California and Wisconsin, including facility costs and laboratory-related expenses. The Company does not separately track research and development expenses by individual research and development projects, or by individual drug candidates. The Company operates in a cross-functional manner across projects and does not separately allocate facilities-related costs, candidate costs, discovery costs, compensation expenses, depreciation and amortization expenses, and other expenses related to research and development activities.

The following tables provide details of research and development expenses for the periods indicated:

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| ***(in thousands)*** | **Three Months Ended <br>June 30, 2025** | **% of**<br>**Expense**<br>**Category**  | **Three Months Ended <br>June 30, 2024** | **% of**<br>**Expense**<br>**Category**  | **Increase (Decrease)** |
| ***(in thousands)*** | **Three Months Ended <br>June 30, 2025** | **% of**<br>**Expense**<br>**Category**  | **Three Months Ended <br>June 30, 2024** | **% of**<br>**Expense**<br>**Category**  | $**%** |
| Candidate costs | $95007 | 58% | $91623 | 60% | 4% |
| R&D discovery costs | 21043 | 13% | 17634 | 12% | 19% |
| Salaries | 26531 | 16% | 24532 | 16% | 8% |
| Facilities related | 6457 | 4% | 7132 | 4% | (9)% |
| Total research and development expense, excluding non-cash expense | $149038 | 91% | $140921 | 92% | 6% |
| Stock compensation | 7612 | 5% | 7241 | 5% | 5% |
| Depreciation and amortization | 5718 | 4% | 4269 | 3% | 34% |
| Total research and development expense | $162368 | 100% | $152431 | 100% | 7% |

---

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| ***(in thousands)*** | **Nine Months Ended <br>June 30, 2025** | **% of**<br>**Expense**<br>**Category**  | **Nine Months Ended <br>June 30, 2024** | **% of**<br>**Expense**<br>**Category**  | **Increase (Decrease)** |
| ***(in thousands)*** | **Nine Months Ended <br>June 30, 2025** | **% of**<br>**Expense**<br>**Category**  | **Nine Months Ended <br>June 30, 2024** | **% of**<br>**Expense**<br>**Category**  | $**%** |
| Candidate costs | $243094 | 56% | $185708 | 50% | 31% |
| R&D discovery costs | 48785 | 11% | 56736 | 15% | (14)% |
| Salaries | 80583 | 19% | 72048 | 19% | 12% |
| Facilities related | 20944 | 5% | 19597 | 7% | 7% |
| Total research and development expense, excluding non-cash expense | $393406 | 91% | $334089 | 91% | 18% |
| Stock compensation | 23049 | 5% | 23735 | 6% | (3)% |
| Depreciation and amortization | 16017 | 4% | 12220 | 3% | 31% |
| Total research and development expense | $432472 | 100% | $370044 | 100% | 17% |

---

Candidate costs increased $3.4 million, or 4%, for the three months ended June 30, 2025 compared to the same period of 2024, and $57.4 million, or 31%, for the nine months ended June 30, 2025 compared to the same period of 2024. The increase for both periods was primarily due to the additional progression of the Company's pipeline of candidates into and through clinical trials, which resulted in higher manufacturing, outsourced clinical trial, and toxicity study costs.

R&D discovery costs increased $3.4 million, or 19%, for the three months ended June 30, 2025 compared to the same period of 2024, primarily driven by animal studies and system support costs. R&D discovery costs decreased $8.0 million, or 14%, for the nine months ended June 30, 2025 compared to the same period of 2024, primarily driven by strategic shifts toward clinical development and commercial launch. R&D discovery costs are influenced by the Company's ongoing discovery efforts, continued advancements into novel therapeutic areas and tissue types, and increasing costs related to CNS studies and lab supplies.

Salaries consist of salary, bonuses, payroll taxes, and related benefits for the Company's R&D personnel. Salaries

------

expense increased $2.0 million, or 8%, for the three months ended June 30, 2025 and $8.5 million, or 12%, for the nine months ended June 30, 2025 compared to the same periods of 2024. The increase for both periods was primarily due to an increase in headcount that has occurred as the Company has expanded its pipeline of candidates, in addition to annual salary increases.

Facilities-related expense includes lease costs for the Company's research and development facilities in San Diego, California and in Madison and Verona, Wisconsin. These expenses decreased $0.7 million, or 9%, for the three months ended June 30, 2025 compared to the same period of 2024, due to refunds received related to the San Diego and Madison buildings. These expenses increased $1.3 million, or 7%, for the nine months ended June 30, 2025 compared to the same period of 2024, primarily due to property taxes charged to the laboratory and office facilities in Verona, Wisconsin, which completed their build out during the first quarter of fiscal 2024.

Stock compensation expense, a non-cash expense, is primarily based on the valuation of the restricted stock units granted to employees, which is based on the closing stock price on the grant date. Stock compensation expense increased $0.4 million, or 5%, for the three months ended June 30, 2025 compared to the same period of 2024, primarily due to an increase in headcount. Stock compensation decreased $0.7 million, or 3%, for the nine months ended June 30, 2025 compared to the same period of 2024, primarily due to the cancellation of awards upon the departure of employees.

Depreciation and amortization expense, a non-cash expense, relates to depreciation on buildings, lab equipment and leasehold improvements. These expenses increased $1.4 million, or 34% for the three months ended June 30, 2025 and $3.8 million, or 31%, for the nine months ended June 30, 2025 compared to the same periods of 2024. The increase was primarily attributable to completion of the build out of facilities in Verona, Wisconsin, and the commencement of depreciation.

***General & Administrative Expenses***

The following tables provide details of general and administrative expenses for the periods indicated:

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| ***(in thousands)*** | **Three Months Ended <br>June 30, 2025** | **% of**<br>**Expense**<br>**Category**  | **Three Months Ended <br>June 30, 2024** | **% of**<br>**Expense**<br>**Category**  | **Increase (Decrease)** |
| ***(in thousands)*** | **Three Months Ended <br>June 30, 2025** | **% of**<br>**Expense**<br>**Category**  | **Three Months Ended <br>June 30, 2024** | **% of**<br>**Expense**<br>**Category**  | $**%** |
| Salaries | $7964 | 26% | $6740 | 28% | 18% |
| Professional, outside services, and other | 14869 | 47% | 5410 | 24% | 175% |
| Facilities related | 2180 | 7% | 1238 | 5% | 76% |
| Total general & administrative expense, excluding non-cash expenses | $25013 | 80% | $13388 | 57% | 87% |
| Stock compensation | 5431 | 18% | 9809 | 41% | (45)% |
| Depreciation and amortization | 505 | 2% | 513 | 2% | (2)% |
| Total general & administrative expenses | $30949 | 100% | $23710 | 100% | 31% |

---

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| ***(in thousands)*** | **Nine Months Ended <br>June 30, 2025** | **% of<br>Expense<br>Category** | **Nine Months Ended <br>June 30, 2024** | **% of<br>Expense<br>Category** | **Increase (Decrease)** |
| ***(in thousands)*** | **Nine Months Ended <br>June 30, 2025** | **% of<br>Expense<br>Category** | **Nine Months Ended <br>June 30, 2024** | **% of<br>Expense<br>Category** | $**%** |
| Salaries | $23152 | 27% | $20087 | 28% | 15% |
| Professional, outside services, and other | 35811 | 41% | 16910 | 23% | 112% |
| Facilities related | 4546 | 5% | 3278 | 5% | 39% |
| Total general & administrative expense, excluding non-cash expense | $63509 | 73% | $40275 | 56% | 58% |
| Stock compensation | 21230 | 25% | 30759 | 42% | (31)% |
| Depreciation and amortization | 1525 | 2% | 1350 | 2% | 13% |
| Total general & administrative expense | $86264 | 100% | $72384 | 100% | 19% |

---

Salaries expense increased $1.2 million, or 18%, for the three months ended June 30, 2025 and $3.1 million, or 15%, for the nine months ended June 30, 2025 compared to the same periods of 2024. The increase was driven by the combination of annual salary increases and an increase in headcount required to support the Company's growth as the Company prepares for commercialization.

Professional, outside services, and other expenses include costs related to legal, audit, consulting, patent filings, business insurance, other external services, as well as travel, communication, and technology expenses. These expenses

------

increased $9.5 million, or 175%, for the three months ended June 30, 2025 and $18.9 million, or 112%, for the nine months ended June 30, 2025 compared to the same periods of 2024. The increase for both periods were mainly due to professional services associated with commercialization and business development efforts as the Company prepares for a product launch, including costs for data analytics, marketing and commercial launch support.

Facilities related expense primarily includes rental costs and other facilities-related costs for the Company's corporate headquarters in Pasadena, California. These expenses increased $0.9 million, or 76%, for the three months ended June 30, 2025 and $1.3 million, or 39%, for the nine months ended June 30, 2025 compared to the same periods of 2024. The increase was primarily driven by higher common area maintenance charges, increased staff amenities expenses, and an increase in headcount.

Stock compensation expense, a non-cash expense, is based on the valuation of the restricted stock units granted to employees, which is based on the closing stock price on the grant date. These expenses decreased $4.4 million, or 45%, for the three months ended June 30, 2025 and $9.5 million, or 31%, for the nine months ended June 30, 2025 compared to the same periods of 2024. The decrease was primarily due to lower compensation costs related to performance awards, as the timing of these expenses can vary based on the achievement of related performance targets.

Depreciation and amortization expense, a noncash expense, was primarily related to amortization of leasehold improvements for the Company's corporate headquarters.

**<u>Other (Expense) Income</u>**

Other (expense) income is primarily related to interest income and expense. Other expense increased $15.7 million and $38.0 million for the three and nine months ended June 30, 2025 compared to the same periods of 2024. The increase was primarily due to non-cash interest expense associated with the liability related to the sale of future royalties and the Credit Facility, partially offset by higher income from increased investment yields.

Net loss attributable to Arrowhead Pharmaceuticals, Inc. was $175.2 million and $170.8 million for the three months ended June 30, 2025 and 2024, respectively. Net income attributable to Arrowhead Pharmaceuticals, Inc. was $22.1 million for the nine months ended June 30, 2025 compared to a net loss attributable to Arrowhead Pharmaceuticals, Inc. of $429.0 million for the same period of 2024. Net loss per diluted share was $1.26 and $1.38 for the three months ended June 30, 2025 and 2024, respectively. Net income per diluted share was $0.17 for the nine months ended June 30, 2025 compared to net loss per diluted share of $3.63 for the same period of 2024.

The increase in net loss attributable to Arrowhead Pharmaceuticals, Inc. for the three months ended June 30, 2025 compared to the same period of 2024 was primarily due to higher research and development expenses as the Company's pipeline of candidates has expanded and progressed through clinical trial phases, as well as higher interest expense related to the Financing Agreement. The increase in net income for the nine months ended June 30, 2025 compared to the same period of 2024 was primarily due to an increase in revenue from the Sarepta Collaboration Agreement, partially offset by higher research and development expenses, which have continued to increase as the Company's pipeline of candidates has expanded and progressed through clinical trial phases.

------

**LIQUIDITY AND CAPITAL RESOURCES**

The Company has historically financed its operations through the sale of its equity securities, credit facility, revenue from its licensing and collaboration agreements, and the sale of certain future royalties. Research and development activities have required significant capital investment since the Company's inception and are expected to continue to require significant cash expenditure as the Company's pipeline continues to expand and matures into later stage clinical trials, including commercialization efforts.

The Company's cash, cash equivalents and restricted cash was $129.8 million as of June 30, 2025 compared to $102.7 million as of September 30, 2024. Cash invested in available-for-sale securities was $770.6 million as of June 30, 2025 compared to $578.3 million as of September 30, 2024.

On December 2, 2022, the Company entered into an open market sale agreement (the "Open Market Sale Agreement"), pursuant to which the Company may, from time to time, sell up to $250.0 million in shares of the Company's common stock through Jefferies LLC, acting as the sales agent and/or principal, in an at-the-market offering. As of June 30, 2025, no shares have been issued under the Open Market Sale Agreement.

In August 2024, the Company entered into the Credit Facility, which provides for a senior secured term loan facility of $500.0 million, which includes $400.0 million funded on the closing date with an additional $100.0 million at the Company's option during the seven-year term of the agreement. The Company received net proceeds of $388.9 million, after issuance costs as of September 30, 2024.

On November 25, 2024, the Company entered into a licensing and collaboration agreement with Sarepta. Upon closing, the Company received $325.0 million for the purchase of 11,926,301 shares of common stock, at a price per share of $27.25, and received $500.0 million as an upfront payment on February 24, 2025. The Company is eligible to receive additional milestones of up to $350.0 million over the 12 months from the date of this report. In the event of Sarepta's termination of the licensing and collaboration agreement for convenience, the Company would remain entitled to receive milestone payments totaling $300.0 million in the aggregate minus any milestone previously paid.

Based upon the Company's current cash and investment resources and operating plan, the Company expects to have sufficient liquidity to fund its operations through at least the next twelve months from the date of the issuance of these unaudited consolidated financial statements.

The following table presents a summary of cash flows:

---

| | | |
|:---|:---|:---|
| | **Nine Months Ended June 30,** | **Nine Months Ended June 30,** |
| | **2025** | **2024** |
| | **(in thousands)** | **(in thousands)** |
| Cash Flow from: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Operating activities | $159061 | $(325635) |
| &nbsp;&nbsp;&nbsp;&nbsp;Investing activities | (201913) | (197149) |
| &nbsp;&nbsp;&nbsp;&nbsp;Financing activities | 70337 | 481431 |
| Net increase (decrease) in cash, cash equivalents and restricted cash | $27485 | $(41353) |
| Cash, cash equivalents and restricted cash at end of period | $129793 | $69399 |

---

During the nine months ended June 30, 2025, cash flow provided by operating activities was $159.1 million, which was primarily due to $500.0 million of cash received as part of the Sarepta agreement, partially offset by ongoing expenses related to the Company's research and development programs and general and administrative expenses. Cash used in investing activities amounted to $201.9 million, which was primarily attributable to capital expenditures of $15.2 million and investment purchases of $774.6 million, partially offset by proceeds from maturities of investments of $587.9 million. Cash provided by financing activities of $70.3 million was primarily related to cash received from the issuance of common stock in the Sarepta agreement and pre-funded warrants and stock option exercises (See Note 6 — Stockholders' Equity of Notes to Consolidated Financial Statements of Part I, "Item 1. Financial Statements").

During the nine months ended June 30, 2024, cash flow used in operating activities was $325.6 million, which was primarily due to the ongoing expenses related to the Company's research and development programs and general and administrative expenses. Cash used in investing activities was $197.1 million, which was primarily attributable to capital expenditures of $117.2 million and investment purchases of $428.6 million, partially offset by proceeds from sales and maturities of investments of $348.6 million. Cash provided by financing activities of $481.4 million was primarily related to cash received from the issuance of common stock as well as stock option exercises.

------

**<u>Contractual Obligations</u>**

The Company entered into an amendment to the Financing Agreement with Sixth Street Lending Partners on November 24, 2024 (see Note 12). There has been no other material change in the Company's contractual obligations from that described in Item 7 of its Annual Report on Form 10-K for the fiscal year ended September 30, 2024.

**ITEM 3.&nbsp;&nbsp;&nbsp;&nbsp;QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK**

There has been no material change in the Company's exposure to market risk from that described in Item 7A of its Annual Report on Form 10-K for the fiscal year ended September 30, 2024.

**ITEM 4.&nbsp;&nbsp;&nbsp;&nbsp;CONTROLS AND PROCEDURES**

**Evaluation of Disclosure Controls and Procedures**

The Company maintains disclosure controls and procedures designed to ensure that information required to be disclosed in its reports filed under the Exchange Act is recorded, processed, summarized, and reported within the time periods specified in the SEC rules and forms, and that such information is accumulated and communicated to its management, including its Chief Executive Officer and Chief Financial Officer, as appropriate, to allow for timely decisions regarding required disclosure. In designing and evaluating the disclosure controls and procedures, management recognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving the desired control objectives, and management necessarily was required to apply its judgment in evaluating the cost benefit relationship of possible controls and procedures.

As required by Rule 13a-15(b) of the Exchange Act, the Company carried out an evaluation, under the supervision and with the participation of its management, including its Chief Executive Officer and Chief Financial Officer, of the effectiveness of the design and operation of the Company's disclosure controls and procedures as of the end of the quarter covered by this Quarterly Report on Form 10-Q. Based on the foregoing, the Company's Chief Executive Officer and Chief Financial Officer concluded that the Company's disclosure controls and procedures were effective at the reasonable assurance level.

**Changes in Internal Control Over Financial Reporting**

There has been no change in the Company's internal control over financial reporting during the Company's most recent fiscal quarter that has materially affected, or is reasonably likely to materially affect, the Company's internal control over financial reporting. The Company regularly evaluates its controls and procedures and makes improvements in the design and effectiveness of established controls and procedures and the remediation of any deficiencies which may be identified during this process.

------

**PART II—OTHER INFORMATION**

**ITEM 1.&nbsp;&nbsp;&nbsp;&nbsp;LEGAL PROCEEDINGS**

From time to time, the Company may be involved in routine legal proceedings, as well as demands, claims and threatened litigation, which arise in the normal course of its business. Litigation can be expensive and disruptive to normal business operations. Moreover, the results of legal proceedings, particularly complex legal proceedings, cannot be predicted with any certainty. There have been no material developments in the legal proceedings that the Company disclosed in Part I, Item 3 of its Annual Report on Form 10-K for the fiscal year ended September 30, 2024.

**ITEM 1A.&nbsp;&nbsp;&nbsp;&nbsp;RISK FACTORS**

The Company's business, results of operations and financial conditions are subject to various risks. These risks are described elsewhere in this Quarterly Report on Form 10-Q and in the Company's other filings with the SEC, including the Company's Annual Report on Form 10-K for the fiscal year ended September 30, 2024. There have been no material changes from the risk factors identified in the Company's Annual Report on Form 10-K for the fiscal year ended September 30, 2024.

**ITEM 2.&nbsp;&nbsp;&nbsp;&nbsp;UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS**

None.

**ITEM 3.&nbsp;&nbsp;&nbsp;&nbsp;DEFAULTS UPON SENIOR SECURITIES**

None.

**ITEM 4.&nbsp;&nbsp;&nbsp;&nbsp;MINE SAFETY DISCLOSURES**

Not Applicable.

**ITEM 5.&nbsp;&nbsp;&nbsp;&nbsp;OTHER INFORMATION**

***(c) Trading Plans***

During the quarter ended June 30, 2025, no director or officer (as defined in Exchange Act Rule 16a-1(f)) adopted or terminated any Rule 10b5-1 trading arrangement or non-Rule 10b5-1 trading arrangement.

------

**ITEM 6.&nbsp;&nbsp;&nbsp;&nbsp;EXHIBITS**

---

| | |
|:---|:---|
| **Exhibit<br>Number** | **Document Description** |
| 3.1 | <u>[Amended and Restated Certificate of Incorporation (incorporated by reference from Exhibit 3.3 of the Company's Form 8-K filed on April 6, 2016)](https://www.sec.gov/Archives/edgar/data/879407/000119312516532364/d175317dex33.htm)</u> |
| 3.2 | <u>[Certificate of Amendment to the Amended and Restated Certificate of Incorporation of Arrowhead Pharmaceuticals, Inc](https://www.sec.gov/Archives/edgar/data/879407/000162828023014856/arrowheadpharmaceuticals.htm)</u>. <u>[(incorporated by reference from Exhibit 3.2 of the Company's Form 10-Q filed on May 2, 2023)](https://www.sec.gov/Archives/edgar/data/879407/000119312516532364/d175317dex33.htm)</u> |
| 3.3 | <u>[Second Amended and Restated Bylaws of Arrowhead Pharmaceuticals, Inc., as amended January 24, 2023](https://www.sec.gov/Archives/edgar/data/879407/000162828023001757/arrowheadpharmaceuticals.htm)[(incorporated by reference from Exhibit 3.3 of the Company's Form 10-Q filed on May 2, 2023)](https://www.sec.gov/Archives/edgar/data/879407/000162828023001757/arrowheadpharmaceuticals.htm)</u> |
| 10.1 | <u>[Severance and Change of Control Agreement by and between Company and Christopher Anzalone, dated May 9, 2025](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/ceoseveranceandchangeofcon.htm)[(incorporated by reference from Exhibit 10.1 of the](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/ceoseveranceandchangeofcon.htm)[Company's](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/ceoseveranceandchangeofcon.htm)[Form 10-Q filed on May 12, 2025)](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/ceoseveranceandchangeofcon.htm)</u> |
| 10.2 | <u>[Severance and Change of Control Agreement by and between Company and Daniel Apel, dated May 8, 2025](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/cfoseveranceandchangeofcon.htm)[(incorporated by reference from Exhibit 10.](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/cfoseveranceandchangeofcon.htm)[2](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/cfoseveranceandchangeofcon.htm)[of the](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/cfoseveranceandchangeofcon.htm)[Company's](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/cfoseveranceandchangeofcon.htm)[Form 10-Q filed on May 12, 2025)](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/cfoseveranceandchangeofcon.htm)</u> |
| 10.3 | <u>[Severance and Change of Control Agreement by and between Company and Patrick O'Brien, dated May 9, 2025](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/severanceandchangeofcontro.htm)[(incorporated by reference from Exhibit 10.](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/severanceandchangeofcontro.htm)[3](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/severanceandchangeofcontro.htm)[of the](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/severanceandchangeofcontro.htm)[Company's](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/severanceandchangeofcontro.htm)[Form 10-Q filed on May 12, 2025)](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/severanceandchangeofcontro.htm)</u> |
| 10.4 | <u>[Severance and Change of Control Agreement by and between Company and James Hamilton, dated May 8, 2025](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/cmoseveranceandchangeofcon.htm)[(incorporated by reference from Exhibit 10.](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/cmoseveranceandchangeofcon.htm)[4](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/cmoseveranceandchangeofcon.htm)[of the](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/cmoseveranceandchangeofcon.htm)[Company's](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/cmoseveranceandchangeofcon.htm)[Form 10-Q filed on May 12, 2025)](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/cmoseveranceandchangeofcon.htm)</u> |
| 10.5 | <u>[CFO Retirement Letter by and between Company and Ken Myszkowski, dated May 9, 2025](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/retirementletteragreement-.htm)[(incorporated by reference from Exhibit 10.](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/retirementletteragreement-.htm)[5](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/retirementletteragreement-.htm)[of the](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/retirementletteragreement-.htm)[Company's](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/retirementletteragreement-.htm)[Form 10-Q filed on May 12, 2025)](https://www.sec.gov/Archives/edgar/data/879407/000162828025024666/retirementletteragreement-.htm)</u> |
| 10.6\* | <u>[Amendment No. 1](a106amendmentno12tolease.htm)[2](a106amendmentno12tolease.htm)[to Lease Agreement by and between Arrowhead Madison, Inc. and University Research Park, dated](a106amendmentno12tolease.htm)[June](a106amendmentno12tolease.htm)[1](a106amendmentno12tolease.htm)[1](a106amendmentno12tolease.htm)[, 202](a106amendmentno12tolease.htm)[5](a106amendmentno12tolease.htm)</u> |
| 31.1\* | <u>[Certification of Chief Executive Officer pursuant to Rule 13a-14(a) of the Securities Exchange Act of 1934, as Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002](arwr-06302025xexx311.htm)</u> |
| 31.2\* | <u>[Certification of Chief Financial Officer pursuant to Rule 13a-14(a) of the Securities Exchange Act of 1934, as Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002](arwr-06302025xexx312.htm)</u> |
| 32.1\*\* | <u>[Certification of Chief Executive Officer pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002](arwr-06302025xexx321.htm)</u> |
| 32.2\*\* | <u>[Certification of Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002](arwr-06302025xexx322.htm)</u> |
| 101.INS\* | Inline XBRL Instance Document |
| 101.SCH\* | Inline XBRL Taxonomy Extension Schema Document |
| 101.CAL\* | Inline XBRL Taxonomy Extension Calculation Linkbase Document |
| 101.LAB\* | Inline XBRL Taxonomy Extension Label Linkbase Document |
| 101.PRE\* | Inline XBRL Taxonomy Extension Presentation Linkbase Document |
| 101.DEF\* | Inline XBRL Taxonomy Extension Definition Linkbase Document |
| 104\* | The cover page from this Quarterly Report on Form 10-Q, formatted in Inline XBRL (included as Exhibit 101) |

---

_________________

\*Filed herewith.

\*\*Furnished herewith.

† Certain portions of this exhibit were redacted by means of marking such portions with asterisks because the identified portions are (i) not material and (ii) treated as private or confidential by the Company.

------

**<u>SIGNATURE</u>**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this Quarterly Report on Form 10-Q to be signed on its behalf by the undersigned, thereunto duly authorized.

Dated: August 7, 2025

---

| | |
|:---|:---|
| ARROWHEAD PHARMACEUTICALS, INC. | ARROWHEAD PHARMACEUTICALS, INC. |
| By: | /s/ Daniel Apel |
|  | Daniel Apel<br>Chief Financial Officer |
|  | (Principal Financial Officer and Duly Authorized Officer) |

---

## Exhibit 10.6

![](a106amendmentno12tolease001.jpg)

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![](a106amendmentno12tolease002.jpg)

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![](a106amendmentno12tolease003.jpg)

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![](a106amendmentno12tolease004.jpg)

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![](a106amendmentno12tolease005.jpg)

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![](a106amendmentno12tolease006.jpg)

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## Exhibit 31.1

**Exhibit 31.1**

**CERTIFICATION PURSUANT SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002** 

I, Christopher Anzalone, Chief Executive Officer of Arrowhead Pharmaceuticals, Inc., certify that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.I have reviewed this Quarterly Report on Form 10-Q of Arrowhead Pharmaceuticals, Inc.;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.The registrant's other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)Evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)Disclosed in this report any change in the registrant's internal control over financial reporting that occurred during the registrant's most recent fiscal quarter (the registrant's fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.The registrant's other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.

---

| | |
|:---|:---|
| Date: August 7, 2025 | |
| | /s/ CHRISTOPHER ANZALONE |
| | **Christopher Anzalone** |
| | **Chief Executive Officer** |

---

## Exhibit 31.2

**Exhibit 31.2**

**CERTIFICATION PURSUANT SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002** 

I, Daniel Apel, Chief Financial Officer of Arrowhead Pharmaceuticals, Inc., certify that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.I have reviewed this Quarterly Report on Form 10-Q of Arrowhead Pharmaceuticals, Inc.;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.The registrant's other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)Evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)Disclosed in this report any change in the registrant's internal control over financial reporting that occurred during the registrant's most recent fiscal quarter (the registrant's fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.The registrant's other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.

---

| | |
|:---|:---|
| Date: August 7, 2025 | |
| | /s/ Daniel Apel |
| | **Daniel Apel** |
| | **Chief Financial Officer** |

---

## Exhibit 32.1

**Exhibit 32.1**

**CERTIFICATION PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002** 

I, Christopher Anzalone, Chief Executive Officer of Arrowhead Pharmaceuticals, Inc. (the "Company"), certify, pursuant to Rule 13(a)-14(b) or Rule 15(d)-14(b) of the Securities Exchange Act of 1934 and 18 U.S.C. Section 1350, that (i) the Quarterly Report on Form 10-Q of the Company for the quarterly period ended June 30, 2025, fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, and (ii) the information contained in such Quarterly Report on Form 10-Q fairly presents in all material respects the financial condition and results of operations of the Company.

---

| | |
|:---|:---|
| Date: August 7, 2025 | |
| | /s/ CHRISTOPHER ANZALONE |
| | **Christopher Anzalone** |
| | **Chief Executive Officer** |

---

A signed original of these written statements required by 18 U.S.C. Section 1350 has been provided to Arrowhead Pharmaceuticals, Inc. and will be retained by Arrowhead Pharmaceuticals, Inc. and furnished to the Securities and Exchange Commission or its staff upon request.

## Exhibit 32.2

**Exhibit 32.2**

**CERTIFICATION PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002** 

I, Daniel Apel, Chief Financial Officer of Arrowhead Pharmaceuticals, Inc. (the "Company"), certify, pursuant to Rule 13(a)-14(b) or Rule 15(d)-14(b) of the Securities Exchange Act of 1934 and 18 U.S.C. Section 1350, that (i) the Quarterly Report on Form 10-Q of the Company for the quarterly period ended June 30, 2025, fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, and (ii) the information contained in such Quarterly Report on Form 10-Q fairly presents in all material respects the financial condition and results of operations of the Company.

---

| | |
|:---|:---|
| Date: August 7, 2025 | |
| | /s/ Daniel Apel |
| | **Daniel Apel** |
| | **Chief Financial Officer** |

---

A signed original of these written statements required by 18 U.S.C. Section 1350 has been provided to Arrowhead Pharmaceuticals, Inc. and will be retained by Arrowhead Pharmaceuticals, Inc. and furnished to the Securities and Exchange Commission or its staff upon request.

<br>