# EDGAR Filing Document

**Accession Number:** 0001953530
**File Stem:** 0001104659-23-031531
**Filing Date:** 2023-3
**Character Count:** 30923
**Document Hash:** 863407dc95c1b372b3e3915c74971e53
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-23-031531.hdr.sgml**: 20230313

**ACCESSION NUMBER**: 0001104659-23-031531

**CONFORMED SUBMISSION TYPE**: SC 13G

**PUBLIC DOCUMENT COUNT**: 4

**FILED AS OF DATE**: 20230313

**DATE AS OF CHANGE**: 20230313

**GROUP MEMBERS**: NOVARTIS AG

**GROUP MEMBERS**: NOVARTIS PHARMA AG

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Oculis Holding AG
- **CENTRAL INDEX KEY:** 0001953530
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** V8
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-94014
- **FILM NUMBER:** 23725771

**BUSINESS ADDRESS:**
- **STREET 1:** BAHNHOFSTRASSE 7
- **CITY:** ZUG
- **STATE:** V8
- **ZIP:** 6300
- **BUSINESS PHONE:** 617-937-2423

**MAIL ADDRESS:**
- **STREET 1:** BAHNHOFSTRASSE 7
- **CITY:** ZUG
- **STATE:** V8
- **ZIP:** 6300
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Novartis Bioventures Ltd
- **CENTRAL INDEX KEY:** 0001297709
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** D0
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G

**BUSINESS ADDRESS:**
- **STREET 1:** C/O NOVARTIS INTERNATIONAL AG
- **STREET 2:** WSJ-200.220
- **CITY:** CH-4002 BASEL
- **STATE:** V8
- **ZIP:** 0000000000
- **BUSINESS PHONE:** 41-61-324-6210

**MAIL ADDRESS:**
- **STREET 1:** C/O NOVARTIS INTERNATIONAL AG
- **STREET 2:** WSJ-200.220
- **CITY:** CH-4002 BASEL
- **STATE:** V8
- **ZIP:** 0000000000

**SECURITIES AND EXCHANGE COMMISSION**

**WASHINGTON, DC 20549**

**SCHEDULE 13G**

**Under the Securities Exchange Act of 1934**

**(Amendment No.)\***

**Oculis Holding AG**

(Name of Issuer)

**Ordinary Shares, CHF 0.01 par value per share**

(Title of Class of Securities)

H5870P102

(CUSIP Number)

March 2, 2023

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

◻ Rule 13d-1(b)

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;⌧ Rule 13d-1(c)

◻ Rule 13d-1(d)

\*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, *see* the *Notes*).

&nbsp;&nbsp;**CUSIP No.** **H5870P102**

---

| | | | | |
|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;1. | &nbsp;&nbsp; Names of Reporting Persons<br> **Novartis Bioventures Ltd.** | &nbsp;&nbsp; Names of Reporting Persons<br> **Novartis Bioventures Ltd.** | &nbsp;&nbsp; Names of Reporting Persons<br> **Novartis Bioventures Ltd.** | &nbsp;&nbsp; Names of Reporting Persons<br> **Novartis Bioventures Ltd.** |
| &nbsp;&nbsp;2. | &nbsp;&nbsp; Check the Appropriate Box if a Member of a Group (see instructions) | &nbsp;&nbsp; Check the Appropriate Box if a Member of a Group (see instructions) | &nbsp;&nbsp; Check the Appropriate Box if a Member of a Group (see instructions) |  |
|  | &nbsp;&nbsp;(a) | &nbsp;&nbsp;(a) | &nbsp;&nbsp;(a) | &nbsp;&nbsp;◻ |
|  | &nbsp;&nbsp;(b) | &nbsp;&nbsp;(b) | &nbsp;&nbsp;(b) | &nbsp;&nbsp;◻ |
| &nbsp;&nbsp;3. | &nbsp;&nbsp;SEC USE ONLY | &nbsp;&nbsp;SEC USE ONLY | &nbsp;&nbsp;SEC USE ONLY | &nbsp;&nbsp;SEC USE ONLY |
| &nbsp;&nbsp;4. | &nbsp;&nbsp; Citizenship or Place of Organization<br> **Switzerland** | &nbsp;&nbsp; Citizenship or Place of Organization<br> **Switzerland** | &nbsp;&nbsp; Citizenship or Place of Organization<br> **Switzerland** | &nbsp;&nbsp; Citizenship or Place of Organization<br> **Switzerland** |
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp;5. | &nbsp;&nbsp; Sole Voting Power<br> **0** | &nbsp;&nbsp; Sole Voting Power<br> **0** |
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp;6. | &nbsp;&nbsp; Shared Voting Power<br> **1,776,182** | &nbsp;&nbsp; Shared Voting Power<br> **1,776,182** |
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp;7. | &nbsp;&nbsp; Sole Dispositive Power<br> **0** | &nbsp;&nbsp; Sole Dispositive Power<br> **0** |
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp;8. | &nbsp;&nbsp; Shared Dispositive Power<br> **1,776,182** | &nbsp;&nbsp; Shared Dispositive Power<br> **1,776,182** |
| &nbsp;&nbsp;9. | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br> **1,776,182** | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br> **1,776,182** | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br> **1,776,182** | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br> **1,776,182** |
| &nbsp;&nbsp;10. | &nbsp;&nbsp;Check if the Aggregate Amount in Row (9) Excludes Certain Shares (see instructions) | &nbsp;&nbsp;Check if the Aggregate Amount in Row (9) Excludes Certain Shares (see instructions) | &nbsp;&nbsp;Check if the Aggregate Amount in Row (9) Excludes Certain Shares (see instructions) | &nbsp;&nbsp;◻ |
| &nbsp;&nbsp;11. | &nbsp;&nbsp; Percent of Class Represented by Amount in Row 9<br> **5.4%<sup>(1)</sup>** | &nbsp;&nbsp; Percent of Class Represented by Amount in Row 9<br> **5.4%<sup>(1)</sup>** | &nbsp;&nbsp; Percent of Class Represented by Amount in Row 9<br> **5.4%<sup>(1)</sup>** | &nbsp;&nbsp; Percent of Class Represented by Amount in Row 9<br> **5.4%<sup>(1)</sup>** |
| &nbsp;&nbsp;12. | &nbsp;&nbsp; Type of Reporting Person (see instructions)<br> **CO** | &nbsp;&nbsp; Type of Reporting Person (see instructions)<br> **CO** | &nbsp;&nbsp; Type of Reporting Person (see instructions)<br> **CO** | &nbsp;&nbsp; Type of Reporting Person (see instructions)<br> **CO** |

---

**(1) Based on 32,733,373 Ordinary Shares outstanding, as reported in the Issuer's 20-F filed with the Securities and Exchange Commission on March 7, 2023.**

&nbsp;&nbsp;**CUSIP No.** **H5870P102**

---

| | | | | |
|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;1. | &nbsp;&nbsp; Names of Reporting Persons<br> **Novartis Pharma AG** | &nbsp;&nbsp; Names of Reporting Persons<br> **Novartis Pharma AG** | &nbsp;&nbsp; Names of Reporting Persons<br> **Novartis Pharma AG** | &nbsp;&nbsp; Names of Reporting Persons<br> **Novartis Pharma AG** |
| &nbsp;&nbsp;2. | &nbsp;&nbsp; Check the Appropriate Box if a Member of a Group (see instructions) | &nbsp;&nbsp; Check the Appropriate Box if a Member of a Group (see instructions) | &nbsp;&nbsp; Check the Appropriate Box if a Member of a Group (see instructions) |  |
|  | &nbsp;&nbsp;(a) | &nbsp;&nbsp;(a) | &nbsp;&nbsp;(a) | &nbsp;&nbsp;◻ |
|  | &nbsp;&nbsp;(b) | &nbsp;&nbsp;(b) | &nbsp;&nbsp;(b) | &nbsp;&nbsp;◻ |
| &nbsp;&nbsp;3. | &nbsp;&nbsp;SEC USE ONLY | &nbsp;&nbsp;SEC USE ONLY | &nbsp;&nbsp;SEC USE ONLY | &nbsp;&nbsp;SEC USE ONLY |
| &nbsp;&nbsp;4. | &nbsp;&nbsp; Citizenship or Place of Organization<br> **Delaware** | &nbsp;&nbsp; Citizenship or Place of Organization<br> **Delaware** | &nbsp;&nbsp; Citizenship or Place of Organization<br> **Delaware** | &nbsp;&nbsp; Citizenship or Place of Organization<br> **Delaware** |
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp;5. | &nbsp;&nbsp; Sole Voting Power<br> **0** | &nbsp;&nbsp; Sole Voting Power<br> **0** |
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp;6. | &nbsp;&nbsp; Shared Voting Power<br> **401,720** | &nbsp;&nbsp; Shared Voting Power<br> **401,720** |
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp;7. | &nbsp;&nbsp; Sole Dispositive Power<br> **0** | &nbsp;&nbsp; Sole Dispositive Power<br> **0** |
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp;8. | &nbsp;&nbsp; Shared Dispositive Power<br> **401,720** | &nbsp;&nbsp; Shared Dispositive Power<br> **401,720** |
| &nbsp;&nbsp;9. | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br> **401,720** | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br> **401,720** | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br> **401,720** | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br> **401,720** |
| &nbsp;&nbsp;10. | &nbsp;&nbsp;Check if the Aggregate Amount in Row (9) Excludes Certain Shares (see instructions) | &nbsp;&nbsp;Check if the Aggregate Amount in Row (9) Excludes Certain Shares (see instructions) | &nbsp;&nbsp;Check if the Aggregate Amount in Row (9) Excludes Certain Shares (see instructions) | &nbsp;&nbsp;◻ |
| &nbsp;&nbsp;11. | &nbsp;&nbsp; Percent of Class Represented by Amount in Row 9<br> **1.2%<sup>(1)</sup>** | &nbsp;&nbsp; Percent of Class Represented by Amount in Row 9<br> **1.2%<sup>(1)</sup>** | &nbsp;&nbsp; Percent of Class Represented by Amount in Row 9<br> **1.2%<sup>(1)</sup>** | &nbsp;&nbsp; Percent of Class Represented by Amount in Row 9<br> **1.2%<sup>(1)</sup>** |
| &nbsp;&nbsp;12. | &nbsp;&nbsp; Type of Reporting Person (see instructions)<br> **CO** | &nbsp;&nbsp; Type of Reporting Person (see instructions)<br> **CO** | &nbsp;&nbsp; Type of Reporting Person (see instructions)<br> **CO** | &nbsp;&nbsp; Type of Reporting Person (see instructions)<br> **CO** |

---

**(1) Based on 32,733,373 Ordinary Shares outstanding, as reported in the Issuer's 20-F filed with the Securities and Exchange Commission on March 7, 2023.**

&nbsp;&nbsp;**CUSIP No.** **H5870P102**

---

| | | | | |
|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;1. | &nbsp;&nbsp; Names of Reporting Persons<br> **Novartis AG** | &nbsp;&nbsp; Names of Reporting Persons<br> **Novartis AG** | &nbsp;&nbsp; Names of Reporting Persons<br> **Novartis AG** | &nbsp;&nbsp; Names of Reporting Persons<br> **Novartis AG** |
| &nbsp;&nbsp;2. | &nbsp;&nbsp; Check the Appropriate Box if a Member of a Group (see instructions) | &nbsp;&nbsp; Check the Appropriate Box if a Member of a Group (see instructions) | &nbsp;&nbsp; Check the Appropriate Box if a Member of a Group (see instructions) |  |
|  | &nbsp;&nbsp;(a) | &nbsp;&nbsp;(a) | &nbsp;&nbsp;(a) | &nbsp;&nbsp;◻ |
|  | &nbsp;&nbsp;(b) | &nbsp;&nbsp;(b) | &nbsp;&nbsp;(b) | &nbsp;&nbsp;◻ |
| &nbsp;&nbsp;3. | &nbsp;&nbsp;SEC USE ONLY | &nbsp;&nbsp;SEC USE ONLY | &nbsp;&nbsp;SEC USE ONLY | &nbsp;&nbsp;SEC USE ONLY |
| &nbsp;&nbsp;4. | &nbsp;&nbsp; Citizenship or Place of Organization<br> **Switzerland** | &nbsp;&nbsp; Citizenship or Place of Organization<br> **Switzerland** | &nbsp;&nbsp; Citizenship or Place of Organization<br> **Switzerland** | &nbsp;&nbsp; Citizenship or Place of Organization<br> **Switzerland** |
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp;5. | &nbsp;&nbsp; Sole Voting Power<br> 0 | &nbsp;&nbsp; Sole Voting Power<br> 0 |
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp;6. | &nbsp;&nbsp; Shared Voting Power<br> **2,177,902<sup>(1)</sup>** | &nbsp;&nbsp; Shared Voting Power<br> **2,177,902<sup>(1)</sup>** |
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp;7. | &nbsp;&nbsp; Sole Dispositive Power<br> 0 | &nbsp;&nbsp; Sole Dispositive Power<br> 0 |
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With: | &nbsp;&nbsp;8. | &nbsp;&nbsp; Shared Dispositive Power<br> **2,177,902<sup>(1)</sup>** | &nbsp;&nbsp; Shared Dispositive Power<br> **2,177,902<sup>(1)</sup>** |
| &nbsp;&nbsp;9. | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br> **2,177,902<sup>(1)</sup>** | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br> **2,177,902<sup>(1)</sup>** | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br> **2,177,902<sup>(1)</sup>** | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br> **2,177,902<sup>(1)</sup>** |
| &nbsp;&nbsp;10. | &nbsp;&nbsp;Check if the Aggregate Amount in Row (9) Excludes Certain Shares (see instructions) | &nbsp;&nbsp;Check if the Aggregate Amount in Row (9) Excludes Certain Shares (see instructions) | &nbsp;&nbsp;Check if the Aggregate Amount in Row (9) Excludes Certain Shares (see instructions) | &nbsp;&nbsp;◻ |
| &nbsp;&nbsp;11. | &nbsp;&nbsp; Percent of Class Represented by Amount in Row 9<br> **6.7%<sup>(2)</sup>** | &nbsp;&nbsp; Percent of Class Represented by Amount in Row 9<br> **6.7%<sup>(2)</sup>** | &nbsp;&nbsp; Percent of Class Represented by Amount in Row 9<br> **6.7%<sup>(2)</sup>** | &nbsp;&nbsp; Percent of Class Represented by Amount in Row 9<br> **6.7%<sup>(2)</sup>** |
| &nbsp;&nbsp;12. | &nbsp;&nbsp; Type of Reporting Person (see instructions)<br> **CO, HC** | &nbsp;&nbsp; Type of Reporting Person (see instructions)<br> **CO, HC** | &nbsp;&nbsp; Type of Reporting Person (see instructions)<br> **CO, HC** | &nbsp;&nbsp; Type of Reporting Person (see instructions)<br> **CO, HC** |

---

**(1) Consists of (i) 1,776,182 Ordinary Shares held by Novartis Bioventures Ltd. and (ii) 401,720 Ordinary Shares held by Novartis Pharma AG. Novartis Bioventures Ltd. and Novartis Pharma AG are each wholly owned indirect subsidiaries of Novartis AG. As the indirect parent of Novartis Bioventures, Ltd. and Novartis Pharma AG, Novartis AG shares voting and dispositive power over, and may be deemed to beneficially own, the reported securities.**

**(2) Based on 32,733,373 Ordinary Shares outstanding, as reported in the Issuer's 20-F filed with the Securities and Exchange Commission on March 7, 2023.**

---

| | |
|:---|:---|
| **Item 1(a).** | **Name of Issuer:**<br> Oculis Holding AG |
| **Item 1(b).** | **Address of Issuer's Principal Executive Offices:**<br> Bahnhofstrasse 7, CH-6300 Zug, Switzerland |
| **Item 2(a).** | **Name of Person Filing:**<br> This statement is filed on behalf of the following persons with respect to the Ordinary Shares of the Issuer:<br> (i) Novartis Bioventures Ltd., a Swiss corporation ("NBV"), with respect to shares held by it;<br> (ii) Novartis Pharma AG, a Swiss corporation ("NPhAG"), with respect to shares held by it; and<br> (ii) Novartis AG, a Swiss corporation ("Novartis"), as the publicly owned parent of NBV and NPhAG, with respect to the shares held by those entities.<br> The foregoing persons are hereinafter referred to collectively as the "Reporting Persons." |
| **Item 2(b).** | **Address of Principal Business Office or, if none, Residence:**<br> The address of the principal business office of NBV, NPhAG and Novartis is Lichtstrasse 35, 4056 Basel, Switzerland. |
| **Item 2(c).** | **Citizenship:**<br> NBV is a corporation organized under the laws of Switzerland and is an indirect wholly owned subsidiary of Novartis.<br> NPhAG is a corporation organized under the laws of Switzerland and is an indirect wholly owned subsidiary of Novartis.<br> Novartis is a corporation organized under the laws of Switzerland and is the publicly owned parent of NBV and NPhAG. |
| **Item 2(d).** | **Title of Class of Securities:**<br> Ordinary Shares, CHF 0.01 par value per share ("Ordinary Shares"). |
| **Item 2(e).** | **CUSIP Number:**<br> H5870P102 |
| **Item 3.** | **If this statement is filed pursuant to §§240.13d-1(b), or 240.13d-2(b) or (c), check whether the person filing is a:** |
| (a) | ◻ Broker or dealer registered under Section 15 of the Act (15 U.S.C. 78o); |
| (b) | ◻ Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c); |
| (c) | ◻ Insurance company as defined in section 3(a)19) of the Act (15 U.S.C. 78c); |
| (d) | ◻ Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8); |
| (e) | ◻ An investment adviser in accordance with §240.13d-1(b)(1)(ii)(E); |
| (f) | ◻ An employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F); |
| (g) | ◻ A parent holding company or control person in accordance with §240.13d-1(b)(1)(ii)(G); |
| (h) | ◻ A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813); |
| (i) | ◻ A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3); |
| (j) | ◻ A non-U.S. institution in accordance with §240.13d–1(b)(1)(ii)(J); |
| (k) | ◻ Group, in accordance with §240.13d–1(b)(1)(ii)(K). |
|  | If filing as a non-U.S. institution in accordance with §240.13d–1(b)(1)(ii)(J), please specify the type of institution: ____ |

---

**Item 4.** **Ownership**

**(a)** Amount Beneficially Owned:

NBV is the beneficial owner of 1,776,182 Ordinary Shares of the Issuer. NPhAG is the beneficial owner of 401,720 Ordinary Shares of the Issuer. As the indirect parent of NBV and NPhAG, Novartis may be deemed to beneficially own these securities. Each of NBV and NPhAG expressly disclaim beneficial ownership of shares beneficially owned by the other entity.

**(b)** Percent of Class:

NBV, NPhAG and Novartis beneficially own 5.4%, 1.2% and 6.7%, respectively, of the Issuer's outstanding Ordinary Shares, based upon 32,733,373 Ordinary Shares issued and outstanding as of March 2, 2023, as reported by the Issuer in a Form 20-F filed with the Securities and Exchange Commission on March 7, 2023.

**(c)** Number of shares as to which the person has:

**(i)** Sole power to vote or to direct the vote: Not applicable as to each Reporting Person.

**(ii)** Shared power to vote or to direct the vote: Please see Row 6 of the cover sheet to this Schedule 13G for each Reporting Person, which information is incorporated herein by reference.

**(iii)** Sole power to dispose or to direct the disposition of: Not applicable as to each Reporting Person.

**(iv)** Shared power to dispose or to direct the disposition of: Please see Row 8 of the cover sheet to this Schedule 13G for each Reporting Person, which information is incorporated herein by reference.

**Item 5.** **Ownership of 5 Percent or Less of a Class**

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than 5 percent of the class of securities, check the following ◻.

**Item 6.** **Ownership of More than 5 Percent on Behalf of Another Person**

Not Applicable

**Item 7.** **Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.**

Not Applicable

**Item 8.** **Identification and Classification of Members of the Group**

Not Applicable

**Item 9.** **Notice of Dissolution of a Group**

Not Applicable

**Item 10.** **Certification**

Each of the Reporting Persons hereby makes the following certification:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

**Signatures**

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Date: March 13, 2023

---

| |
|:---|
| Novartis Bioventures Ltd. |
| /s/ Bart Dzikowski |
| Name: Bart Dzikowski |
| Title: Secretary of the Board |
| /s/ Beat Steffen |
| Name: Beat Steffen |
| Title: Authorized Signatory |
| Novartis Pharma AG |
| /s/ Bart Dzikowski |
| Name: Bart Dzikowski |
| Title: Authorized Signatory |
| /s/ Beat Steffen |
| Name: Beat Steffen |
| Title: Authorized Signatory |
| Novartis AG |
| /s/ Bart Dzikowski |
| Name: Bart Dzikowski |
| Title: Authorized Signatory |
| /s/ Beat Steffen |
| Name: Beat Steffen |
| Title: Authorized Signatory |

---

**EXHIBIT INDEX**

---

| | |
|:---|:---|
| <u>Exhibit Number</u> | <u>Exhibit Description</u> |
| [1](tm239106d1_ex99-1.htm) | [Powers of Attorney](tm239106d1_ex99-1.htm) |
| [2](tm239106d1_ex99-2.htm) | [Evidence of Signatory Authority](tm239106d1_ex99-2.htm) |
| [3](tm239106d1_ex99-3.htm) | [Joint Filing Agreement](tm239106d1_ex99-3.htm) |

---

## Exhibit 99.1

**EXHIBIT 1**

**POWER OF ATTORNEY**

We, the undersigned, under the authority granted to each of us to sign jointly on behalf of Novartis AG, hereby grant powers to Bart Dzikowski, Anja Koenig, Florian Muellershausen, Marianne Uteng, Mathias Frederiksen, Beat Steffen and Helena Sanchez, and constitute and appoint any two of them jointly as our true and lawful attorneys and representatives and to act on our behalf and to sign filings to be made with the U.S. Securities and Exchange Commission (the "<u>SEC</u>") relating to the shares of Oculis S.A. and its successor companies held by Novartis Bioventures Ltd., an indirect subsidiary of Novartis AG, as required by the SEC (the "<u>SEC Filings</u>"), and to undertake and carry out all tasks and formalities on our behalf which may be required in connection with giving effect to the SEC Filings.

We, the undersigned, undertake to ratify and confirm whatever our true and lawful attorneys do or purport to do in good faith in the exercise of any power conferred by this Power of Attorney.

We, the undersigned, declare that a person who deals with our true and lawful attorneys in good faith may accept a written statement signed by such attorneys to the effect that this Power of Attorney has not been revoked as conclusive evidence of that fact.

The authority granted by this Power of Attorney shall expire immediately after the SEC Filings are no longer required.

**IN WITNESS WHEREOF**, this Power of Attorney is duly signed on this 18 day of October 2022.

---

| |
|:---|
| Novartis AG |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ L. Förtsch |
| Name: Lukas Förtsch |
| Title: Authorized Signatory |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ C. Rehm |
| Name: Christian Rehm |
| Title: Authorized Signatory |

---

**POWER OF ATTORNEY**

We, the undersigned, under the authority granted to each of us to sign jointly on behalf of Novartis Pharma AG, hereby grant powers to Bart Dzikowski, Marc Ceulemans, Anja Koenig, Florian Muellershausen, Marianne Uteng, Mathias Frederiksen, Beat Steffen and Helena Sanchez, and constitute and appoint any two of them jointly as our true and lawful attorneys and representatives and to act on our behalf and to sign filings to be made with the U.S. Securities and Exchange Commission (the "<u>SEC</u>") relating to the shares of Oculis S.A. and its successor companies held by Novartis Pharma AG, as required by the SEC (the "<u>SEC Filings</u>"), and to undertake and carry out all tasks and formalities on our behalf which may be required in connection with giving effect to the SEC Filings.

We, the undersigned, undertake to ratify and confirm whatever our true and lawful attorneys do or purport to do in good faith in the exercise of any power conferred by this Power of Attorney.

We, the undersigned, declare that a person who deals with our true and lawful attorneys in good faith may accept a written statement signed by such attorneys to the effect that this Power of Attorney has not been revoked as conclusive evidence of that fact.

The authority granted by this Power of Attorney shall expire immediately after the SEC Filings are no longer required.

**IN WITNESS WHEREOF**, this Power of Attorney is duly signed on this 3 day of November 2022.

---

| |
|:---|
| Novartis AG |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ L. Förtsch |
| Name: Lukas Förtsch |
| Title: Authorized Signatory |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ B. Bugnon |
| Name: Bertrand Bugnon |
| Title: Authorized Signatory |

---

## Exhibit 99.2

**EXHIBIT 2**

**EVIDENCE OF SIGNATORY AUTHORITY**

<u>Excerpt from Commercial Register of Novartis AG</u>

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| Identification number | Legal status | Entry | Cancelled | Carried CH-270.3.002.061-2 |  |
|  |  |  |  | from: CH-270.3.002.061-2/a | &nbsp;&nbsp;&nbsp;&nbsp;**1** |
| **CHE-103.867.266** | **Limited or Corporation** | 01.03.1996 |  | on: |  |

---

All data

---

| | | | | |
|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;In | Ca | Business name | Ref | Legal seat |
| &nbsp;&nbsp;&nbsp;1 |  | **Novartis AG** | &nbsp;&nbsp;&nbsp;1 | Basel |
| &nbsp;&nbsp;&nbsp;1 |  | (Novartis SA) (Novartis Inc.) |  |  |

---

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| **CHE-103.867.266** | **CHE-103.867.266** | **Novartis AG** | **Novartis AG** | **Basel** | **5** |
| All data | All data | All data | All data | All data | All data |
| In | Mo Ca | Personal Data | Function | Signature | Signature |
|  | 28 | Rehm, Christian Jakob, von Illanz/Glion, in Muttenz |  | joint signature at two | joint signature at two |

---

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| **CHE-103.867.266** | **CHE-103.867.266** | **Novartis AG** | **Novartis AG** | **Basel** | **5** |
| All data | All data | All data | All data | All data | All data |
| In | Mo Ca | Personal Data | Function | Signature | Signature |
| 14 |  | Förtsch, Lukas, von Zürich, in Sissach |  | joint signature at two | joint signature at two |

---

<u>Excerpt from Commercial Register of Novartis Pharma AG</u>

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| Identification number | Legal status | Entry | Cancelled | Carried CH-270.3.004.604-7 |  |
|  |  |  |  | from: CH-270.3.004.604-7/b | &nbsp;&nbsp;&nbsp;&nbsp;**1** |
| **CHE-106.052.527** | **Limited or Corporation** | 25.10.1989 |  | on: |  |

---

All data

---

| | | | | |
|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;In | Ca | Business name | Ref | Legal seat |
| &nbsp;&nbsp;&nbsp;1 |  | **Novartis Pharma AG** | &nbsp;&nbsp;&nbsp;1 | Basel |
| &nbsp;&nbsp;&nbsp;1 |  | (Novartis Pharma SA) (Novartis Pharma Inc.) |  |  |

---

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| **CHE-106.052.527** | **CHE-106.052.527** | **Novartis AG** | **Novartis AG** | **Basel** | **9** |
| All data | All data | All data | All data | All data | All data |
| In | Mo Ca | Personal Data | Function | Signature | Signature |
|  | 43 | Bugnon, Bertrand Richard René, von Montagny (FR), in Belfaux |  | joint signature at two | joint signature at two |

---

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| **CHE-106.052.527** | **CHE-106.052.527** | **Novartis AG** | **Novartis AG** | **Basel** | **10** |
| All data | All data | All data | All data | All data | All data |
| In | Mo Ca | Personal Data | Function | Signature | Signature |
| 55 |  | Förtsch, Lukas, von Zürich, in Sissach |  | joint signature at two | joint signature at two |

---

## Exhibit 99.3

**EXHIBIT 3**

**Joint Filing Agreement**

In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, the undersigned agree to the joint filing on behalf of each of them of a Statement on Schedule 13G (including amendments thereto) with respect to the Ordinary Shares, CHF 0.01 par value per share, of Oculis Holding AG, a Swiss corporation, and further agree that this Joint Filing Agreement shall be included as an exhibit to such joint filings.

The undersigned further agree that each party hereto is responsible for the timely filing of such Schedule 13G and any amendments thereto, and for the completeness and accuracy of the information concerning such party contained therein; <u>provided</u> that no party is responsible for the completeness or accuracy of the information concerning any other filing party, unless such party knows or has reason to believe that such information is inaccurate.

This Joint Filing Agreement may be executed in one or more counterparts, each of which shall be deemed to be an original instrument, but all of such counterparts together shall constitute one agreement.

In evidence thereof, the undersigned, being duly authorized, hereby execute this Joint Filing Agreement as of March 13, 2023.

---

| |
|:---|
| Novartis Bioventures Ltd. |
| /s/ Bart Dzikowski |
| Name: Bart Dzikowski |
| Title: Secretary of the Board |
| /s/ Beat Steffen |
| Name: Beat Steffen |
| Title: Authorized Signatory |
| Novartis Pharma AG |
| /s/ Bart Dzikowski |
| Name: Bart Dzikowski |
| Title: Authorized Signatory |
| /s/ Beat Steffen |
| Name: Beat Steffen |
| Title: Authorized Signatory |
| Novartis AG |
| /s/ Bart Dzikowski |
| Name: Bart Dzikowski |
| Title: Authorized Signatory |
| /s/ Beat Steffen |
| Name: Beat Steffen |
| Title: Authorized Signatory |

---