# EDGAR Filing Document

**Accession Number:** 0001682639
**File Stem:** 0001104659-25-111287
**Filing Date:** 2025-11
**Character Count:** 73045
**Document Hash:** 074af0f56c5e3eadaf0bb2d9adb8ace2
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-25-111287.hdr.sgml**: 20251113

**ACCESSION NUMBER**: 0001104659-25-111287

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 32

**CONFORMED PERIOD OF REPORT**: 20251113

**ITEM INFORMATION**: Results of Operations and Financial Condition

**ITEM INFORMATION**: Regulation FD Disclosure

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20251113

**DATE AS OF CHANGE**: 20251113

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** HYPERION DEFI, INC.
- **CENTRAL INDEX KEY:** 0001682639
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 471178401
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-38365
- **FILM NUMBER:** 251478510

**BUSINESS ADDRESS:**
- **STREET 1:** 295 MADISON AVENUE
- **STREET 2:** SUITE 2400
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10017
- **BUSINESS PHONE:** 833-393-6684

**MAIL ADDRESS:**
- **STREET 1:** 295 MADISON AVENUE
- **STREET 2:** SUITE 2400
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10017

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** EYENOVIA, INC.
- **DATE OF NAME CHANGE:** 20160818

?xml version='1.0' encoding='ASCII'?

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**FORM 8-K**

**CURRENT REPORT**

**Pursuant to Section 13 or 15(d)**

**of the Securities Exchange Act of 1934**

**Date of Report (Date of earliest event reported): November 13, 2025**

**HYPERION DEFI, INC.**

**(Exact Name of Registrant as Specified in its Charter)**

---

| | | |
|:---|:---|:---|
| **Delaware** | **001-38365** | **47-1178401** |
| **(State or other jurisdiction <br> of incorporation)** | **(Commission<br> File Number)** | **(IRS Employer<br> Identification No.)** |

---

23461 South Pointe Drive, Suite 390 Laguna Hills, CA 92653

**(Address of Principal Executive Offices, and Zip Code)**

(833) 393-6684

**Registrant's Telephone Number, Including Area Code**

(Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

◻ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

◻ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

◻ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

◻ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

---

| | | |
|:---|:---|:---|
| **(Title of each class)** | **(Trading <br> Symbol)** | **(Name of each exchange <br> on which registered)** |
| **Common stock, par value $0.0001 per share** | **HYPD** | **The Nasdaq Stock Market<br> (Nasdaq Capital Market)** |

---

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2).

Emerging growth company ◻

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻

**Item 2.02. Results of Operations and Financial Condition.**

On November 13, 2025, Hyperion DeFi, Inc. (the "Company") issued a press release announcing its financial results for the fiscal quarter ended September 30, 2025. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated herein by reference.

The information contained in this Item 2.02, including Exhibit 99.1, is being "furnished" and shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liability of that Section or Sections 11 and 12(a)(2) of the Securities Act of 1933, as amended (the "Securities Act"). The information contained in this Item 2.02, including Exhibit 99.1, shall not be incorporated by reference into any registration statement or other document pursuant to the Securities Act or into any filing or other document pursuant to the Exchange Act, except as otherwise expressly stated in any such filing.

**Item 7.01. Regulation FD Disclosure.**

On November 13, 2025, the Company will host a conference call to discuss its financial and operating results for the quarter ended September 30, 2025. A copy of the investor presentation that will be used during this conference call is furnished as Exhibit 99.2 to this Current Report on Form 8-K and is incorporated herein by reference.

The information contained in this Item 7.01, including Exhibit 99.2, is being "furnished" and shall not be deemed "filed" for purposes of Section 18 of the Exchange Act or otherwise subject to the liability of that Section or Sections 11 and 12(a)(2) of the Securities Act. The information contained in this Item 7.01, including Exhibit 99.2, shall not be incorporated by reference into any registration statement or other document pursuant to the Securities Act or into any filing or other document pursuant to the Exchange Act, except as otherwise expressly stated in any such filing.

**Item 9.01. Financial Statements and Exhibits.**

(d) <u>Exhibits</u>

---

| | |
|:---|:---|
| **<u>Exhibit Number</u>** | **<u>Description</u>** |
| [99.1](tm2531076d1_ex99-1.htm) | [Press Release, dated November 13, 2025.](tm2531076d1_ex99-1.htm) |
| [99.2](tm2531076d1_ex99-2.htm) | [Investor Presentation, dated November 13, 2025.](tm2531076d1_ex99-2.htm) |
| 104 | Cover Page Interactive Data File (embedded within the inline XBRL document). |

---

**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

---

| | | |
|:---|:---|:---|
|  | **HYPERION DEFI, INC.** | **HYPERION DEFI, INC.** |
| Dated: November 13, 2025 | By: | */s/ Hyunsu Jung* |
|  |  | Hyunsu Jung |
|  |  | Interim Chief Executive Officer |

---

## Exhibit 99.1

**Exhibit 99.1**

![](tm2531076d1_ex99-1img001.jpg)

**Hyperion DeFi Reports Third Quarter 2025 Financial Results with Record Net Income of $6.6 Million**

*Management Initiates Q4'25 Adjusted Revenue<sup>(3)</sup> Guidance of 31% to 43% Q-o-Q Growth*

*Over 13 Million HYPE Tokens Staked to Hyperion's Validator as of October 31, 2025*

*Ramping Business Lines Expected to Achieve Positive Operating Cash Flows in 2026*

LAGUNA HILLS, Calif., November 13, 2025 -- Hyperion DeFi, Inc. (NASDAQ: HYPD) ("Hyperion DeFi" or the "Company"), the first U.S. publicly listed company building a long-term strategic treasury of Hyperliquid's native token, HYPE, today reported results for the third quarter ending September 30, 2025.

"This has been an extraordinary six months for Hyperion DeFi, and we are still in the early stages of our evolution," said Hyunsu Jung, Interim CEO of Hyperion DeFi.

Mr. Jung continued, "We've successfully executed what we believe represents one of the most significant corporate transformations in recent public market history - pivoting from Eyenovia's ophthalmic technology focus to establishing ourselves as a premier institutional gateway to DeFi innovation. In our first full quarter with our new digital asset treasury strategy, not only did we achieve record net income for the Company, but we have established multiple business lines on the Hyperliquid blockchain which we expect to continue to scale through the fourth quarter, into 2026, and beyond."

**Key Operating & Financial Results<sup>(1)</sup>**

---

| | |
|:---|:---|
|  | **Q3 2025** |
|  | (Unless Otherwise Indicated) |
| HYPE – Digital Assets<sup>(2)</sup> | $37954590 |
| **Gross HYPE Holdings<sup>(3)</sup>** | $**77751604** |
| Gross HYPE Tokens<sup>(5)</sup> | 1720549 |
| HYPE Tokens Staked at Kinetiq x Hyperion Validator as of 9/30<sup>(4)</sup> | 8249233 |
| HYPE Tokens Staked at Kinetiq x Hyperion Validator as of 10/31<sup>(4)</sup> | 13210917 |
| **Net Asset Value<sup>(3)</sup>** | $**74545583** |
| Revenue | $302506 |
| **Adjusted Revenue<sup>(3)</sup>** | $**361277** |
| Income From Operations | $4428191 |
| **Net Income** | $**6625582** |
| Net Income Attributable to Participating Securities | $5830582 |
| Weighted Average Common Shares Outstanding - Basic | 6027713 |
| Weighted Average Common Shares Outstanding - Diluted | 28951915 |
| Net Income Per Common Share - Basic | $0.26 |
| Net Income Per Common Share - Diluted | $0.05 |
| **Adjusted EBITDA<sup>(3)</sup>** | $**7951003** |

---

![](tm2531076d1_ex99-1img001.jpg)

**Q3'25 Financial Results**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· Revenue
 significantly increased from $1,625 in Q3'24 to $302,506 in Q3'25.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· Generated
 Q3'25 Adjusted Revenue<sup>(3)</sup> of $361,277.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· Realized
 gains – digital assets, Unrealized gains – digital assets, and Impairment loss
 – digital intangible assets were $6.9 million, $6.4 million, and $(6.3 million), respectively,
 combined totaling $7.1 million.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· Research
 and development expenses decreased 89% from $3.5 million in Q3'24 to $0.4 million in
 Q3'25.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· Selling,
 general and administrative expenses declined 30% from $3.7 million in Q3'24 to $2.6
 million in Q3'25.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· Gain
 on extinguishment of liability and a reduction in accrued liability within other income was
 $2.2 million and $0.2 million respectively, combined totaling $2.4 million.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· Income
 from operations increased from a loss of $(7.3 million) in Q3'24 to income of $4.4
 million in Q3'25, a record high for the Company.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· Net
 income increased from a loss of $(7.9 million) in Q3'24 to income of $6.6 million in
 Q3'25, a record high for the Company.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· Net
 income attributable to participating securities was $5.8 million in Q3'25.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· Net
 income per common share in Q3'25 from a basic and diluted perspective was $0.26 and
 $0.05, respectively.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· Adjusted
 EBITDA<sup>(3)</sup> was $8.0 million in Q3'25.

**Validator Operating Results**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· In
 2025, the Company launched a co-brand validator, "Kinetiq x Hyperion". A definitive
 Joint Validator Agreement was executed in October 2025 among the Company, Kinetiq, and
 Pier Two.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· The
 number of HYPE tokens staked at the Kinetiq x Hyperion Validator was 8.2 million as of September 30,
 2025 and 13.2 million as of October 31, 2025, a 60% month-over-month increase.<sup>(4)</sup>

**Cash Flow**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· Net
 cash used in operating activities decreased from $(24.0 million) for the nine months ended
 September 30, 2024 to $(10.7 million) for the nine months ended September 30, 2025.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· Net
 cash used in investing activities increased from $(0.2 million) for the nine months ended
 September 30, 2024 to $(65.6 million) for the nine months ended September 30, 2025,
 primarily as a result of the purchase of HYPE tokens pursuant to the Company's digital
 asset treasury strategy, which launched in June 2025.

**Balance Sheet and Liquidity**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· Cash
 and cash equivalents totaled $8.2 million as of September 30, 2025.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· HYPE
 – digital assets totaled $38.0 million market value, and Gross HYPE Holdings<sup>(3)</sup> totaled $77.8 million market value on 1.7 million
 tokens as of September 30, 2025.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· Debt
 totaled $7.7 million as of September 30, 2025 (net of debt discount of $0.6 million).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· Net
 asset value<sup>(3)</sup> totaled $74.5 million as of September 30, 2025.

![](tm2531076d1_ex99-1img001.jpg)

**Financial Guidance**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· We
 anticipate Q4'25 Adjusted Revenues of $475,000 to $515,000, representing 31% to 43%
 Quarter-on-Quarter Growth versus Q3'25.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· We
 anticipate our operating cash flow to turn positive in 2026.

*(1) All financial information in this press release is unaudited. Throughout this document, totals may not sum due to rounding. Calculations are based on unrounded results. N.M. is the abbreviation for "Not Meaningful".*

*(2) "HYPE – Digital Assets", a GAAP measure, does not include HiHYPE, which is Hyperion's liquid staking HYPE token.*

*(3) See "Non-GAAP Financial Measures" below for an explanation and reconciliations of non-GAAP measures used throughout this press release.*

*(4) Supplemental operating disclosure; information on the number of tokens staked at the Company's validator is available real-time via public sources.*

*(5) Unaudited supplemental disclosure more fully described on the Reconciliation of GAAP HYPE - Digital Assets to Non-GAAP Gross HYPE Holdings.*

![](tm2531076d1_ex99-1img001.jpg)

**Description of Business Activities in Q3'25**

Hyperion DeFi is the first U.S. publicly listed company building a long-term strategic treasury of Hyperliquid's native token, HYPE. The Company is focused on providing its shareholders with simplified access to the Hyperliquid ecosystem, one of the fastest growing, highest revenue-generating blockchains in the world. Shareholders benefit from a gradually compounding exposure to HYPE, both from its native staking yield and additional revenues generated from its unique on-chain utility.

The Company's Q3'25 operating business activities are summarized below:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. <u>Staking Rewards</u>:
 The Company stakes its HYPE to its Validator and earns rewards.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. <u>Validator Commissions</u>:
 The Company operates its Validator under a Joint Validator Operators Agreement (together
 with Kinetiq and Pier Two) and earns commissions on rewards delivered to third-party tokens
 delegated to the Validator.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3. <u>Yield Enhancement</u>:
 The Company pursues accretive strategies to enhance yield earned on its tokens.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o In
 Q3'25, this included the launch of the Company's "HiHYPE" (Hyperion
 iHYPE) liquid staking token, gains on covered call option strategies (included in the realized
 and unrealized gains on digital assets income statement line items), and certain liquid staking
 activities.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4. <u>DeFi Monetization</u>:
 The Company supports and monetizes DeFi activity on the Hyperliquid blockchain with sustainable,
 scalable practices.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o In
 Q3'25, this included the launch of the Company's proprietary "HAUS"
 platform ("HYPE Asset Use Service"), which allows its clients to unlock unique
 utility on Hyperliquid while generating fee income for Hyperion DeFi.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o The
 Company announced its first HAUS transaction with Credo in September 2025, which enables
 Credo to receive the benefit of lower trading fees on the Hyperliquid decentralized exchange,
 with Hyperion DeFi receiving a portion of those savings as income (while continuing to earn
 staking rewards).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o The
 Company's second HAUS transaction was announced with Felix in October 2025, enabling
 Felix's launch of new financial markets on the Hyperliquid blockchain, with Hyperion
 DeFi receiving a portion of fees generated from their markets (while continuing to earn staking
 rewards).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5. <u>Ecosystem Rewards</u>:
 Through its active participation in the Hyperliquid DeFi ecosystem, the Company positions
 itself for the receipt of future potential token airdrops, protocol incentives, and other
 rewards that may become available periodically. In Q3'25, the Company's Validator
 received over 3 million tokens delegated from the Hyperliquid Foundation.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6. <u>Life Sciences</u>:
 Hyperion DeFi continues to develop its proprietary Optejet User Filled Device (UFD).

![](tm2531076d1_ex99-1img001.jpg)

**Conference Call & Webcast**

Hyperion DeFi, Inc. will host a conference call to discuss third quarter 2025 results at 5:00 p.m. Eastern Time on November 13, 2025. A slide presentation that includes supplemental financial information and reconciliations of certain non-GAAP measures to their most directly comparable GAAP measures can be accessed through the Company's Investor Relations website at https://ir.hyperiondefi.com/events-and-presentations along with information for the conference call. Participants may submit questions in advance of the call via email to IR@hyperiondefi.com. A webcast of the call will be archived and available through Thursday, November 27, 2025 at 11:59 on the Company's website.

**Presentation**

All growth rates represent year-over-year comparisons, except as otherwise noted. All amounts in tables are presented in U.S. dollars, rounded to the nearest dollar, except as otherwise noted. As a result, certain amounts and rates may not sum or recalculate using the rounded dollar amounts provided.

**About the Hyperliquid Platform and the HYPE Token**

Hyperliquid is a next-generation layer one blockchain optimized for high frequency, transparent trading. The blockchain includes fully on-chain perpetual futures and spot order books, with every order, cancel, trade, and liquidation occurring within 70 millisecond block times. It also hosts the HyperEVM, a general-purpose smart contract platform that supports permissionless decentralized financial applications akin to Ethereum.

HYPE is the native token of Hyperliquid. Staked HYPE provides utility for users via reduced trading fees and increased referral bonuses. As of October 2025, more than 30 million HYPE have been autonomously purchased and sequestered by the blockchain with the trading fees generated on the network's central limit order books.

**About Hyperion DeFi, Inc.**

Hyperion DeFi, Inc. is the first U.S. publicly listed company building a long-term strategic treasury of HYPE. The Company provides investors with streamlined access to the Hyperliquid ecosystem, one of the fastest growing, highest revenue-generating blockchains in the world. Shareholders benefit from compounding exposure to HYPE, both from its native staking yield and additional revenues generated from its unique on-chain utility.

Hyperion DeFi is also developing its proprietary Optejet User Filled Device (UFD) that is designed to work with a variety of topical ophthalmic liquids, including artificial tears and lens rewetting products. The Optejet is especially useful in chronic front-of-the-eye diseases due to its ease of use, enhanced safety and tolerability, and potential for superior compliance versus standard eye drops. Together, these benefits may result in higher treatment compliance and better outcomes for patients and providers.

For more information, please visit Hyperiondefi.com.

![](tm2531076d1_ex99-1img001.jpg)

**Forward Looking Statements; Disclaimer**

Except for historical information, all the statements, expectations and assumptions contained in this press release are forward-looking statements. Forward-looking statements include, but are not limited to, statements that express our intentions, beliefs, expectations, strategies, predictions or any other statements, our future activities or other future events or conditions, including the estimated market opportunities for our platform technology, the viability of, and risks associated with, our cryptocurrency treasury strategy, and the growth and revenue potential of the Hyperliquid ecosystem and the growth prospects of the Company. These statements are based on current expectations, estimates and projections about our business based, in part, on assumptions made by management. These statements are not guarantees of future performance and involve risks, uncertainties and assumptions that are difficult to predict. Therefore, actual outcomes and results may, and in some cases are likely to, differ materially from what is expressed or forecasted in the forward-looking statements due to numerous factors discussed from time to time in documents which we file with the U.S. Securities and Exchange Commission (the "SEC").

Any forward-looking statements speak only as of the date on which they are made, and except as may be required under applicable securities laws, Hyperion DeFi does not undertake any obligation to update any forward-looking statements.

Certain information contained in this press release and statements made orally during the corresponding earnings call relate to or are based on studies, publications, surveys and other data obtained from third-party sources and Hyperion DeFi's own internal estimates and research. While Hyperion DeFi believes these third-party studies, publications, surveys and other data to be reliable as of the date of this press release, it has not independently verified, and makes no representation as to the adequacy, fairness, accuracy or completeness of, any information obtained from third-party sources. In addition, no independent source has evaluated the reasonableness or accuracy of Hyperion DeFi's internal estimates or research and no reliance should be made on any information or statements made in this press release relating to or based on such internal estimates and research. You should conduct your own investigation and analysis of Hyperion DeFi, its business, prospects, results of operations and financial condition. In furnishing this information, Hyperion DeFi does not undertake any obligation to provide you with access to any additional information (including forward-looking information and any projections contained herein) or to update or correct the information.

![](tm2531076d1_ex99-1img001.jpg)

**Hyperion DeFi, Inc. Investor Contact:**

Jason Assad

Hyperion DeFi, Inc.

IR@hyperiondefi.com

(678) 570-6791

![](tm2531076d1_ex99-1img001.jpg)

**Hyperion DeFi, Inc.**

**Condensed Balance Sheet**

---

| | | |
|:---|:---|:---|
|  | **September 30,**<br>**2025** | **December 31,**<br>**2024** |
|  | **(unaudited)** | |
| **Assets** |  |  |
| Current Assets |  |  |
| &nbsp;&nbsp;&nbsp;Cash and cash equivalents | $8223180 | $2121463 |
| &nbsp;&nbsp;&nbsp;Prepaid expenses and other current assets | 862587 | 645736 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total Current Assets | 9085767 | 2767199 |
| HYPE - digital assets | 37954590 |  |
| Digital intangible assets | 35019932 |  |
| Operating lease right-of-use asset | 491589 | 718360 |
| Other assets | 238029 | 182200 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total Assets | $82789907 | $3667759 |
| **Liabilities and Stockholders' Equity (Deficit)** |  |  |
| Current Liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;Accounts payable | $1138750 | $1954681 |
| &nbsp;&nbsp;&nbsp;Accrued former licensor obligations |  | 2245087 |
| &nbsp;&nbsp;&nbsp;Accrued expenses and other current liabilities | 2403686 | 1322674 |
| &nbsp;&nbsp;&nbsp;Operating lease liabilities - current portion | 494656 | 575163 |
| &nbsp;&nbsp;&nbsp;Notes payable - current portion, net of debt discount of $0 and $527,870 as of September 30, 2025 and December 31, 2024, respectively |  | 5212532 |
| &nbsp;&nbsp;&nbsp;Convertible notes payable - current portion, net of debt discount of $0 and $263,930 as of September 30, 2025 and December 31, 2024, respectively |  | 4736070 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total Current Liabilities | 4037092 | 16046207 |
| &nbsp;&nbsp;&nbsp;Notes payable - non-current portion, net of debt discount of $598,691 and $0 as of September 30, 2025 and December 31, 2024, respectively | 7656005 |  |
| &nbsp;&nbsp;&nbsp;Operating lease liabilities - non-current portion | 341778 | 717504 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total Liabilities | 12034875 | 16763711 |
| Commitments and contingencies (Note 9) |  |  |
| Stockholders' Equity (Deficit): |  |  |
| &nbsp;&nbsp;&nbsp;Preferred stock, $0.0001 par value, 60,000,000 shares authorized; Series A Non-Voting Convertible Preferred Stock, 5,435,898 shares designated, and 5,435,897 and 0 shares issued and outstanding as of September 30, 2025 and December 31, 2024, respectively | 544 |  |
| &nbsp;&nbsp;&nbsp;Common stock, $0.0001 par value, 600,000,000 shares authorized; 7,162,659 and 1,506,369 shares issued and outstanding as of September 30, 2025 and December 31, 2024, respectively | 715 | 151 |
| &nbsp;&nbsp;&nbsp;Additional paid-in capital | 271612635 | 182213889 |
| &nbsp;&nbsp;&nbsp;Accumulated deficit | (200858862) | (195309992) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total Stockholders' Equity (Deficit) | 70755032 | (13095952) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total Liabilities and Stockholders' Equity (Deficit) | $82789907 | $3667759 |

---

![](tm2531076d1_ex99-1img001.jpg)

**Hyperion DeFi, Inc.**

**Condensed Statement of Operations**

**(unaudited)**

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **For the Three Months Ended** | **For the Three Months Ended** | **For the Nine Months Ended** | **For the Nine Months Ended** |
|  | **September 30,** | **September 30,** | **September 30,** | **September 30,** |
|  | **2025** | **2024** | **2025** | **2024** |
| Revenue | $302506 | 1625 | $317226 | $29243 |
| Cost of revenue |  | (132522) | (48) | (825910) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Gross Profit (Loss) | 302506 | (130897) | 317178 | (796667) |
| **Operating (Income) Expenses:** |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Research and development | 373855 | 3471939 | 1721476 | 12500713 |
| &nbsp;&nbsp;&nbsp;Selling, general and administrative | 2594130 | 3729091 | 12645156 | 11125115 |
| &nbsp;&nbsp;&nbsp;Realized gains - digital assets | (6942713) |  | (6942713) |  |
| &nbsp;&nbsp;&nbsp;Unrealized gains - digital assets | (6440804) |  | (6440804) |  |
| &nbsp;&nbsp;&nbsp;Impairment loss - digital intangible assets | 6289847 |  | 6289847 |  |
| &nbsp;&nbsp;&nbsp;Reacquisition of license rights |  |  |  | 4864600 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net Operating (Income) Expenses | (4125685) | 7201030 | 7272962 | 28490428 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Income (Loss) From Operations | 4428191 | (7331927) | (6955784) | (29287095) |
| **Other Income (Expense):** |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Other income (expense), net | 131525 | 1184 | 304052 | (93394) |
| &nbsp;&nbsp;&nbsp;Gain on extinguishment of liability | 2245088 |  | 2334711 |  |
| &nbsp;&nbsp;&nbsp;Change in fair value of equity consideration payable |  |  |  | 1240800 |
| &nbsp;&nbsp;&nbsp;Interest expense | (223080) | (602109) | (1332989) | (1954768) |
| &nbsp;&nbsp;&nbsp;Interest income | 43858 | 44999 | 101140 | 230804 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total Other Income (Expense), Net | 2197391 | (555926) | 1406914 | (576558) |
| **Net Income (Loss)** | 6625582 | (7887853) | (5548870) | (29863653) |
| &nbsp;&nbsp;&nbsp;Dividend to preferred stockholders | (795000) |  | (892167) |  |
| **Net Income (Loss) Attributable to Participating Securities** | $5830582 | $(7887853) | $(6441037) | $(29863653) |
| **Net Income (Loss) per Common Share** |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Basic | $0.26 | $(9.07) | $(1.64) | $(42.30) |
| &nbsp;&nbsp;&nbsp;Diluted | $0.05 | $(9.07) | $(1.64) | $(42.30) |
| **Weighted Average Number of Common Shares Outstanding:** |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Basic | 6027713 | 869479 | 3930764 | 705961 |
| &nbsp;&nbsp;&nbsp;Diluted | 28951915 | 869479 | 3930764 | 705961 |

---

**Hyperion DeFi, Inc.**

**Condensed Statements of Changes in Stockholders' Equity (Deficiency)**

**For the Three and Nine Months Ended September 30, 2025**

**(unaudited)**

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
|  | **Preferred Stock** | **Preferred Stock** | **Common Stock** | **Common Stock** | | | |
|  | **Shares** | **Amount** | **Shares** | **Amount** | **Additional**<br>**Paid-In**<br>**Capital** |<br>**Accumulated**<br>**Deficit** | **Total**<br>**Stockholders'**<br>**Equity (Deficit)** |
| **Balance - January 1, 2025** |  | $— | 1506369 | $151 | $182213889 | $(195309992) | $(13095952) |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of common stock in At the Market offering [1] |  |  | 1127100 | 113 | 5663153 |  | 5663266 |
| &nbsp;&nbsp;&nbsp;&nbsp;Induced exercise of stock warrants [2] |  |  | 197118 | 19 | 922731 |  | 922750 |
| &nbsp;&nbsp;&nbsp;&nbsp;Reverse stock split settlement of fractional shares |  |  | (41) |  | (160) |  | (160) |
| &nbsp;&nbsp;&nbsp;&nbsp;Stock-based compensation |  |  |  |  | 279628 |  | 279628 |
| &nbsp;&nbsp;&nbsp;&nbsp;Net loss |  |  |  |  |  | (3483533) | (3483533) |
| **Balance - March 31, 2025** |  |  | 2830546 | 283 | 189079241 | (198793525) | (9714001) |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of preferred stock and warrants in private placement [3] | 5435897 | 544 |  |  | 49365206 |  | 49365750 |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of common stock in At the Market offering [4] |  |  | 1323389 | 132 | 2559008 |  | 2559140 |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of common stock from exercise of warrants |  |  | 252000 | 25 | 1953479 |  | 1953504 |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of common stock from the delivery of vested restricted stock units |  |  | 44072 | 4 | (4) |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of common stock from the partial conversion of note payable |  |  | 404820 | 41 | 640295 |  | 640336 |
| &nbsp;&nbsp;&nbsp;&nbsp;Warrants issued in consideration for debt modification |  |  |  |  | 858270 |  | 858270 |
| &nbsp;&nbsp;&nbsp;&nbsp;Stock-based compensation |  |  |  |  | 483654 |  | 483654 |
| &nbsp;&nbsp;&nbsp;&nbsp;Net loss |  |  |  |  |  | (8690919) | (8690919) |
| &nbsp;&nbsp;&nbsp;&nbsp;Preferred stock dividend |  |  |  |  | (97167) |  | (97167) |
| **Balance - June 30, 2025** | 5435897 | 544 | 4854827 | 485 | 244841982 | (207484444) | 37358567 |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of common stock in At the Market offering [5] |  |  | 1929207 | 192 | 21783753 |  | 21783945 |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of common stock from exercise of warrants [6] |  |  | 250125 | 25 | 1938944 |  | 1938969 |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of common stock from the delivery of vested restricted stock units |  |  | 128500 | 13 | (13) |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Stock-based compensation |  |  |  |  | 3842969 |  | 3842969 |
| &nbsp;&nbsp;&nbsp;&nbsp;Net income |  |  |  |  |  | 6625582 | 6625582 |
| &nbsp;&nbsp;&nbsp;&nbsp;Preferred stock dividend |  |  |  |  | (795000) |  | (795000) |
| **Balance - September 30, 2025** | 5435897 | $544 | 7162659 | $715 | $271612635 | $(200858862) | $70755032 |

---

[1] Includes gross proceeds of $5,851,007 less total issuance costs of $187,741.

[2] Includes gross proceeds of $1,039,206 less total issuance costs of $116,456. Also note that incremental value and non-cash warrant modification and additional warrants issuance costs related to the warrant inducement entered into on January 16, 2025 offset to a zero balance.

[3] Includes gross proceeds of $50,000,000 less total issuance costs of $634,250.

[4] Includes gross proceeds of $2,657,659 less total issuance costs of $98,519.

[5] Includes gross proceeds of $22,489,548 less total issuance costs of $705,603.

[6] Partial exercise of the Armistice warrants.

![](tm2531076d1_ex99-1img001.jpg)

**Hyperion DeFi, Inc.**

**Condensed Statements of Changes in Stockholders' Equity (Deficiency)**

**For the Three and Nine Months Ended September 30, 2024**

**(unaudited)**

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
|  | **Preferred Stock** | **Preferred Stock** | **Common Stock** | **Common Stock** | | | |
|  | **Shares** | **Amount** | **Shares** | **Amount** | **Additional**<br>**Paid-In**<br>**Capital** |<br>**Accumulated**<br>**Deficit** | **Total**<br>**Stockholders'**<br>**Equity (Deficit)** |
| **Balance - January 1, 2024** |  | $— | 569409 | $57 | $154490596 | $(145491559) | $8999094 |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of common stock in At the Market offering [7] |  |  | 22917 | 2 | 3194545 |  | 3194547 |
| &nbsp;&nbsp;&nbsp;&nbsp;Cashless exercise of stock options |  |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Stock-based compensation |  |  |  |  | 546232 |  | 546232 |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of common stock related to vested restricted stock units |  |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Net loss |  |  |  |  |  | (10922101) | (10922101) |
| **Balance - March 31, 2024** |  |  | 592326 | 59 | 158231373 | (156413660) | 1817772 |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of common stock in registered direct offering [8] |  |  | 40297 | 4 | 1888825 |  | 1888829 |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of common stock as consideration for licensing agreement [9] |  |  | 7669 | 1 | 436808 |  | 436809 |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of common stock as consideration for reacquisition of licensing agreement [10] |  |  | 28742 | 3 | 2322388 |  | 2322391 |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of common stock in At the Market offering [11] |  |  | 28687 | 3 | 1676936 |  | 1676939 |
| &nbsp;&nbsp;&nbsp;&nbsp;Stock-based compensation |  |  |  |  | 541056 |  | 541056 |
| &nbsp;&nbsp;&nbsp;&nbsp;Net loss |  |  |  |  |  | (11053699) | (11053699) |
| **Balance - June 30, 2024** |  |  | 697720 | 70 | 165097386 | (167467359) | (2369903) |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of common stock and warrants in offerings [12] |  |  | 363197 | 36 | 12348142 |  | 12348178 |
| &nbsp;&nbsp;&nbsp;&nbsp;Warrant modification - incremental value [13] |  |  |  |  | 2868000 |  | 2868000 |
| &nbsp;&nbsp;&nbsp;&nbsp;Warrant modification - in issuance costs for registered direct offering [14] |  |  |  |  | (2868000) |  | (2868000) |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of common stock in At the Market offering [15] |  |  | 18779 | 2 | 1175881 |  | 1175883 |
| &nbsp;&nbsp;&nbsp;&nbsp;Stock-based compensation |  |  |  |  | 452998 |  | 452998 |
| &nbsp;&nbsp;&nbsp;&nbsp;Net loss |  |  |  |  |  | (7887853) | (7887853) |
| **Balance – September 30, 2024** |  | $— | 1079696 | $108 | $179074407 | $(175355212) | $3719303 |

---

[7] Includes gross proceeds of $3,293,347 less total issuance costs of $98,800.

[8] Includes gross proceeds of $2,000,000 less total issuance costs of $111,171.

[9] Shares issued as partial consideration for License Agreement with Formosa Pharmaceuticals Inc.

[10] Shares issued in partial consideration for reacquisition of License Agreement with Bausch & Lomb Ireland Limited.

[11] Includes gross proceeds of $1,728,804 less total issuance costs of $51,868.

[12] Includes gross proceeds of $14,139,994 less total issuance costs of $1,791,816.

[13] Offering includes modification of warrants and additional warrants in the July 2024 offering.

[14] Non-cash warrant modification and additional warrants issuance costs related to one of the offerings of $2,868,000 are shown on a separate line item.

[15] Includes gross proceeds of $1,212,251 less total issuance costs of $36,368.

![](tm2531076d1_ex99-1img001.jpg)

**Hyperion DeFi, Inc.**

**Condensed Statements of Cash Flows**

**(unaudited)**

---

| | | |
|:---|:---|:---|
|  | **For the Nine Months Ended** | **For the Nine Months Ended** |
|  | **September 30,** | **September 30,** |
|  | **2025** | **2024** |
| **Cash Flows From Operating Activities** |  |  |
| &nbsp;&nbsp;&nbsp;Net loss | $(5548870) | $(29863653) |
| &nbsp;&nbsp;&nbsp;Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Stock-based compensation | 4606251 | 1540286 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Change in fair value of equity consideration payable |  | (1240800) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Depreciation of property and equipment |  | 830605 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Amortization of debt discount | 640969 | 552620 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Write-off of property and equipment |  | 88251 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Write-down of inventories to net realizable value |  | 769217 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Reacquisition of license rights |  | 2864600 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Non-cash lease expense | 226771 | 391028 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Gain on extinguishment of liabilities | (2334711) |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Unrealized gain on HYPE digital assets | (6.440.804) |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Non-cash realized gain on HYPE digital assets | (6.938.236) |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Impairment loss - digital intangible assets | 6289847 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;HYPE staking income | (323980) |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Interest expense added to note principal | 295329 |  |
| &nbsp;&nbsp;&nbsp;Changes in operating assets and liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Prepaid expenses and other current assets | (216851) | 836507 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;License fee and expense reimbursement receivables |  | (13761) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Deferred clinical supply costs |  | 1272309 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Inventories |  | (1051023) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Security and equipment deposits | (55829) | 1148 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Accounts payable | (815931) | (179232) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Accrued compensation |  | (1781) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Accrued expenses and other current liabilities | 359662 | (453567) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Lease liabilities | (456233) | (352836) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net Cash Used In Operating Activities | (10712616) | (24010082) |
| **Cash Flows From Investing Activities** |  |  |
| Purchase of property and equipment |  | (161476) |
| &nbsp;&nbsp;&nbsp;Purchase of productive digital assets | (65635000) |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**Net Cash Used In Investing Activities** | (65635000) | (161476) |
| **Cash Flows From Financing Activities** |  |  |
| &nbsp;&nbsp;&nbsp;Proceeds from sale of common stock and warrants in direct offering |  | 16139994 |
| &nbsp;&nbsp;&nbsp;Payment of direct offering costs |  | (1902987) |
| &nbsp;&nbsp;&nbsp;Proceeds from sale of preferred stock and warrants in private placement | 50000000 |  |
| &nbsp;&nbsp;&nbsp;Payment of private placement issuance costs | (634250) |  |
| &nbsp;&nbsp;&nbsp;Proceeds from sale of common stock in At the Market offering | 30998213 | 6234402 |
| &nbsp;&nbsp;&nbsp;Payment of issuance costs for At the Market offering | (991862) | (187033) |
| &nbsp;&nbsp;&nbsp;Proceeds from induced exercise of stock warrants | 1039206 |  |
| &nbsp;&nbsp;&nbsp;Proceeds from exercise of stock warrants | 3892473 |  |
| &nbsp;&nbsp;&nbsp;Payment of cash issuance costs for induced exercise of stock warrants | (116455) |  |
| &nbsp;&nbsp;&nbsp;Reverse stock split settlement of fractional shares | (160) |  |
| &nbsp;&nbsp;&nbsp;Payment of issuance costs for debt modification | (177228) |  |
| &nbsp;&nbsp;&nbsp;Repayments of notes payable | (1463437) | (3773746) |
| &nbsp;&nbsp;&nbsp;Payment of preferred dividend | (97167) |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**Net Cash Provided By Financing Activities** | 82449333 | 16510630 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**Net Increase (Decrease) in Cash and Cash Equivalents** | 6101717 | (7660928) |
| **Cash and Cash Equivalents - Beginning of Period** | 2121463 | 14849057 |
| **Cash and Cash Equivalents - End of Period** | $8223180 | $7188129 |

---

![](tm2531076d1_ex99-1img001.jpg)

**Hyperion DeFi, Inc.**

**Condensed Statements of Cash Flows, continued**

**(unaudited)**

---

| | | |
|:---|:---|:---|
|  | **For the Nine Months Ended** | **For the Nine Months Ended** |
|  | **September 30,** | **September 30,** |
|  | **2025** | **2024** |
| **Supplemental Disclosure of Cash Flow Information:** |  |  |
| &nbsp;&nbsp;&nbsp;Cash paid during the period for: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Interest | $396788 | $1402147 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Taxes | $— | $— |
| **Supplemental Disclosure of Non-Cash Investing and Financing Activities** |  |  |
| &nbsp;&nbsp;&nbsp;Deposits of HYPE into liquid staking activities | $41174779 | $— |
| &nbsp;&nbsp;&nbsp;Purchase of insurance policy financed by note payable | $— | $505050 |
| &nbsp;&nbsp;&nbsp;Accrual for intangible asset milestone obligation | $— | $2000000 |
| &nbsp;&nbsp;&nbsp;Dividend payable | $795000 | $— |
| &nbsp;&nbsp;&nbsp;Reclassification of deferred clinical supply costs to inventories | $— | $2575652 |
| &nbsp;&nbsp;&nbsp;Modification date carrying value of extinguished Avenue Loan | $10262280 | $— |
| &nbsp;&nbsp;&nbsp;Modification date fair value of modified Avenue Loan | $10172657 | $— |
| &nbsp;&nbsp;&nbsp;Warrants issued for debt modification | $858270 | $— |
| &nbsp;&nbsp;&nbsp;Warrant modification and additional warrants - incremental value | $1194102 | $2868000 |
| &nbsp;&nbsp;&nbsp;Conversion of Avenue Loan to common stock | $640336 | $— |
| &nbsp;&nbsp;&nbsp;Common stock issued in consideration for licensing agreement | $— | $436809 |
| &nbsp;&nbsp;&nbsp;Common stock issued in consideration for reacquisition of licensing agreement | $— | $2322391 |
| &nbsp;&nbsp;&nbsp;Issuance of common stock related to vested restricted stock units | $17 | $— |

---

![](tm2531076d1_ex99-1img001.jpg)

**Non-GAAP Financial Measures**

In addition to our results determined in accordance with GAAP, this press release and the accompanying tables contain Adjusted Revenue, Gross HYPE Holdings, Net Asset Value, and Adjusted EBITDA, which are non-GAAP financial measures. Adjusted Revenue, Gross HYPE Holdings, Net Asset Value, and Adjusted EBITDA are unaudited, presented as supplemental disclosure, and should not be considered in isolation or as a substitute for, or superior to, the financial information prepared and presented in accordance with GAAP.

It is important to note that the particular items we exclude from, or include in, Adjusted Revenue, Gross HYPE Holdings, Net Asset Value, and Adjusted EBITDA may differ from the items excluded from, or included in, similar non-GAAP financial measures used by other companies in the same industry. We also periodically review our non-GAAP financial measures and may revise these measures to reflect changes in our business or otherwise.

"Adjusted Revenue" reflects all staking, commissions, and gross operational, asset-generating business activity in-period. It is reconciled to the GAAP measure "Revenue" by adding accumulated but unrealized rewards on HiHYPE. Staking rewards are not recognized from a GAAP Revenue perspective on our liquid staking token; instead, conversion back from HiHYPE into HYPE may result in a gain in connection with recognizing the market value of HYPE (including earned staking rewards) versus derecognizing the carrying value of HiHYPE upon conversion. We believe Adjusted Revenue provides a more complete view of our staking activities and overall recurring business profile, without potential period-to-period variability due to HiHYPE liquid staking activities. As such, Adjusted Revenue is an important metric used by our management for financial, risk management and operational decision-making, and provides an additional tool for investors to use to understand and compare our operating results across accounting periods.

"Gross HYPE Holdings" is the gross market value of the Company's HYPE assuming all HiHYPE tokens were converted back to HYPE tokens as of September 30, 2025. It is reconciled to the GAAP measure "HYPE - Digital Assets" by adding (i) HiHYPE Tokens at carrying value and (ii) the unrealized accretion (dilution) expected upon HiHYPE to HYPE reconversion as of September 30, 2025. We believe Gross HYPE Holdings is a helpful non-GAAP financial measure to our management and investors because it eliminates the temporary financial impacts caused by the conversion of HYPE tokens into HiHYPE tokens, which (a) derecognizes staking rewards and commissions on our HiHYPE tokens and (b) does not recognize upward mark-to-market movements in underlying HYPE tokens given HiHYPE is carried at the lower of cost basis or impaired value. As such, it provides useful information about our balance sheet, allows for greater transparency with respect to important metrics used by our management for financial, risk management and operational decision-making, and provides an additional tool for investors to use to understand and compare our operating results across accounting periods.

![](tm2531076d1_ex99-1img001.jpg)

"Net Asset Value" is the market value of our marketable digital assets less net outstanding debt. It is reconciled to the GAAP measure "HYPE - Digital Assets" by (i) adding HiHYPE Tokens at carrying value, (ii) adding the unrealized accretion (dilution) expected upon HiHYPE to HYPE reconversion, (iii) adding Current Assets, (iv) subtracting Current Liabilities, and (v) subtracting Notes Payable (Non-current portion, without subtracting corresponding debt discounts or any unamortized issuance expenses). We believe Net Asset Value is a helpful non-GAAP financial measure to our management and investors because it provides a more complete picture of our net liquid and marketable assets. It does not include Other Digital Assets which may not be immediately marketable. It does not include other non-current assets or non-current liabilities beyond the aforementioned items. The Company believes Net Asset Value provides useful information about our balance sheet and financial performance, enhances the overall understanding of our past performance and future prospects, allows for greater transparency with respect to important metrics used by our management for financial, risk management and operational decision-making, and provides an additional tool for investors to use to understand and compare our operating results across accounting periods.

"Adjusted EBITDA" is a financial earnings measure meant to reflect management's view of recurring business activities and a more comparable view of the mark-to-market impacts on our digital asset treasury holdings in-period. It is reconciled to the GAAP measure "Net Income (Loss)" by removing (i) equity based compensation, (ii) interest expense, (iii) income taxes, (iv) depreciation and amortization expense (excluding amortization of operating lease), (v) non-recurring gains from reductions in life sciences liabilities, and (vi) other non-recurring items which we do not consider material in nature; and, it adds the in-period change in unrealized accretion (dilution) expected upon HiHYPE to HYPE reconversion. The items excluded from our Adjusted EBITDA are excluded because they are non-cash in nature, or because the amount and timing of these items are unpredictable, are not driven by core results of operations, and render comparisons with prior periods and competitors less meaningful. We add to Adjusted EBITDA the in-period change in unrealized accretion (dilution) expected upon HiHYPE to HYPE reconversion to give a more complete picture of mark-to-market impacts on our HYPE holdings, disregarding the temporary conversion of HYPE to HiHYPE. Adjusted EBITDA is used by management, in addition to GAAP financial measures, to understand and compare our operating results across accounting periods, for risk management and operational decision-making purposes. This non-GAAP measure provides investors with additional information in evaluating the Company's operating performance.

Investors are cautioned that there are material limitations associated with the use of non-GAAP financial measures as an analytical tool.

![](tm2531076d1_ex99-1img001.jpg)

**Hyperion DeFi, Inc.**

**Reconciliation of GAAP Revenue to Non-GAAP Adjusted Revenue**

---

| | |
|:---|:---|
|  | **For the Three<br> Months Ended**<br>**September 30, 2025** |
| **Revenue** | 302506 |
| Add: Accumulated but unrealized staking rewards on HiHYPE<sup>(5)</sup> | 58771 |
| **Adjusted Revenue** | **361277** |

---

(5) Represents staking rewards on staked HYPE tokens which have been derecognized and converted into HiHYPE, which is Hyperion DeFi's liquid staking token. Staking rewards are not recognized from a GAAP Revenue perspective on our liquid staking token; instead, conversion back from HiHYPE into HYPE may result in a gain in connection with recognizing the market value of HYPE (including earned staking rewards) versus derecognizing the carrying value of HiHYPE upon conversion.

![](tm2531076d1_ex99-1img001.jpg)

**Hyperion DeFi, Inc.**

**Reconciliation of GAAP HYPE - Digital Assets to Non-GAAP Gross HYPE Holdings**

*And, supplemental reconciliation of Gross HYPE Tokens<sup>(8)</sup>*

---

| | | | |
|:---|:---|:---|:---|
|  | **September 30, 2025** | **September 30, 2025** | **September 30, 2025** |
|  | **Value $** | **Token Count** | **Token Price** |
| **HYPE - Digital Assets** | **37954590** | **839889** | $**45.19** |
| Add: HiHYPE Tokens at Carrying Value | 34884932 | 877871 | $39.74 |
| Add: Unrealized accretion (dilution) expected upon HiHYPE to HYPE reconversion<sup>(6)</sup> | 4912082 | 2788 | NM |
| **Gross HYPE Holdings** | **77751604** |  |  |
| *Gross HYPE Tokens<sup>(8)</sup>* |  | 1720549 | $45.19 |
| <u>*Memo*</u>*: in-period change in unrealized accretion (dilution) expected upon HiHYPE to HYPE reconversion<sup>(7)</sup>* | 4912082 |  |  |

---

(6) Represents the estimated future financial implications if all company-owned HiHYPE tokens were reconverted to HYPE as of September 30, 2025. Encapsulates both the conversion of HiHYPE to HYPE plus the realization of previously accrued but unrecognized staking rewards.

(7) Represents the change in "Unrealized accretion (dilution) upon future HiHYPE to HYPE reconversion" versus June 30, 2025. The Company did not hold any HiHYPE tokens on or prior to June 30, 2025.

(8) Unaudited supplemental disclosure.

![](tm2531076d1_ex99-1img001.jpg)

**Hyperion DeFi, Inc.**

**Reconciliation of GAAP HYPE - Digital Assets to Non-GAAP Net Asset Value**

---

| | |
|:---|:---|
|  | **September 30, 2025** |
|  | **Value $** |
| **HYPE - Digital Assets** | **37954590** |
| Add: HiHYPE Tokens at Carrying Value | 34884932 |
| Add: Unrealized accretion (dilution) expected upon HiHYPE to HYPE reconversion | 4912082 |
| Add: Current Assets | 9085767 |
| Subtract: Current Liabilities | (4037092) |
| Subtract: Notes Payable<sup>(9)</sup> | (8254696) |
| **Net Asset Value** | **74545583** |

---

(9) Non-current portion; does not subtract debt discount of $598,691 as of September 30, 2025.

![](tm2531076d1_ex99-1img001.jpg)

**Hyperion DeFi, Inc.**

**Reconciliation of GAAP Net Income to Non-GAAP Adjusted EBITDA**

---

| | |
|:---|:---|
|  | **For the Three Months Ended**<br>**September 30, 2025** |
| **Net Income** | 6625582 |
| Add back: |  |
| &nbsp;&nbsp;&nbsp;Equity based compensation | (1347031) |
| &nbsp;&nbsp;&nbsp;Interest expense | 223080 |
| &nbsp;&nbsp;&nbsp;Income Taxes |  |
| &nbsp;&nbsp;&nbsp;Depreciation and amortization expense<sup>(10)</sup> |  |
| &nbsp;&nbsp;&nbsp;Reductions in life sciences liabilities<sup>(11)</sup> | (2407154) |
| &nbsp;&nbsp;&nbsp;Other non-recurring items<sup>(12)</sup> | (55557) |
| Add: in-period change in unrealized accretion (dilution) expected upon HiHYPE to HYPE reconversion | 4912082 |
| **Adjusted EBITDA** | **7951003** |

---

(10) Does not include Amortization of Operating Lease.

(11) Gain on extinguishment of liability and a reduction in accrued liability within other income was $2.2 million and $0.2 million respectively, combined totaling $2.4 million.

(12) Includes gains on sales of equipment, release of reserves held against potential returns of company-sold items, and a one-time realized payment in connection with a terminated LOI.

## Exhibit 99.2

**Exhibit 99.2**

![](tm2531076d1_ex99-2img001.jpg)

Hyperion DeFi© 2025 1 HYPD Q3 2025 Earnings Supplement More than just HYPE. NASDAQ: HYPD

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Hyperion DeFi© 2025 2 Forward - Looking Statements; Disclaimer Except for historical information, all the statements, expectations and assumptions contained in this presentation are forwar d - l ooking statements. Forward - looking statements include, but are not limited to, statements that express our intentions, beliefs, expectations, strat egies, predictions or any other statements, our future activities or other future events or conditions, including the estimated market opportunities fo r o ur platform technology, the viability of, and risks associated with, our cryptocurrency treasury strategy, and the growth and revenue potential of th e Hyperliquid ecosystem and the growth prospects of Hyperion DeFi, Inc. ("Hyperion DeFi", "Hyperion" or the "Company") (NASDAQ:HYPD). These statement s a re based on current expectations, estimates and projections about our business based, in part, on assumptions made by management. These s tat ements are not guarantees of future performance and involve risks, uncertainties and assumptions that are difficult to predict. Therefore, a ctu al outcomes and results may, and in some cases are likely to, differ materially from what is expressed or forecasted in the forward - looking stat ements due to numerous factors discussed from time to time in documents which we file with the U.S. Securities and Exchange Commission (the "SEC"), inc luding in particular, the risks of our cryptocurrency strategy as detailed in our reports filed with the SEC . Any forward - looking statements speak only as of the date on which they are made, and except as may be required under applicable securities laws, Hyperion DeFi does not undertake any obligation to update any forward - looking statements. Certain information contained in this presentation and statements made orally during this presentation relate to or are based on studies, publications, surveys and other data obtained from third - party sources and Hyperion DeFi's own internal estimates and research. While Hyperion DeFi believes these third - party studies, publications, surveys and other data to be reliable as of the date of this presentation, it has not i ndependently verified, and makes no representation as to the adequacy, fairness, accuracy or completeness of, any information obtained from third - party sou rces. In addition, no independent source has evaluated the reasonableness or accuracy of Hyperion DeFi's internal estimates or research and no r eli ance should be made on any information or statements made in this presentation relating to or based on such internal estimates and research. Yo u should conduct your own investigation and analysis of Hyperion DeFi, its business, prospects, results of operations and financial condition. In furnishing this information, Hyperion DeFi does not undertake any obligation to provide you with access to any additional information (includ ing forward - looking information and any projections contained herein) or to update or correct the information. All figures in this deck are not audited.

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Hyperion DeFi© 2025 3 September 30, 2025 (Unless Otherwise Indicated) $37,954,590 HYPE – Digital Assets (1) $77,751,604 Gross HYPE Holdings (2) 1,720,549 Gross HYPE Tokens (3) 8,249,233 HYPE Tokens Staked at Kinetiq x Hyperion Validator (9/30) (4) 13,210,917 HYPE Tokens Staked at Kinetiq x Hyperion Validator (10/31) (4) $74,545,583 Net Asset Value (2) $302,506 Revenue $361,277 Adjusted Revenue (2) $4,428,191 Income From Operations $6,625,582 Net Income $5,830,582 Net Income Attributable to Participating Securities 6,027,713 Weighted Average Common Shares Outstanding - Basic 28,951,915 Weighted Average Common Shares Outstanding - Diluted $0.26 Net Income Per Common Share - Basic $0.05 Net Income Per Common Share - Diluted $7,951,003 Adjusted EBITDA (2) Hyperion DeFi (HYPD): Q3 2025 Key Operating & Financial Results Note: Throughout this document, totals may not sum due to rounding. Calculations are based on unrounded results. N.M. is the ab breviation for "Not Meaningful". (1) "HYPE – Digital Assets", a GAAP measure, does not include " HiHYPE ", which is Hyperion's liquid staking HYPE token. (2) Unaudited Non - GAAP financial measure. Important GAAP to Non - GAAP reconciliations are provided beginning on page 11. (3) Unaudited supplemental disclosure described more fully on page 14. (4) Unaudited supplemental operating disclosure; information is available real - time via public sources.

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Hyperion DeFi© 2025 4 Why Hyperliquid (HYPE)? Top 1 revenue and Top 11 market cap cryptocurrency Source: CoinMarketCap Source: Artemis As of October 31, 2025 Top Fees (24h) NAME 1 Bitcoin BTC 2 Ethereum ETH 3 Tether USDT 4 BNB BNB 5 XRP XRP 6 Solana SOL 7 USDC USDC 8 Dogecoin DOGE 9 TRON TRX 10 Cardano ADA 11 Hyperliquid HYPE 12 Chainlink LINK MARKET CAP $2,186,874,049,462 $464,091,919,702 $183,432,854,301 $149,721,190,958 $148,551,454,148 $102,467,136,308 $75,954,885,285 $28,060,546,470 $27,799,535,500 $21,870,760,277 $14,340,268,312 $11,803,075,719 Market Cap: Top 12 Cryptocurrencies As of October 31, 2025

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Hyperion DeFi© 2025 5 BUYBACKS MARKET CAP (2) STAKING YIELD FIXED SUPPLY TOKEN $2,186,874,049,462 Bitcoin $464,091,919,702 Ethereum $102,467,136,308 Solana $14,340,268,312 Hyperliquid Hyperliquid's Unique Token Design Hyperliquid generates an annualized revenue of ~ $1 . 3 B+ (1) . 99 % of this revenue goes back to daily buybacks of HYPE into the Assistance Fund, a powerful mechanism relative to its circulating market cap . Assistance Fund HYPE ~34.25M Assistance HYPE $~1.45B Source: Hypurrscan (1) Based upon annual daily revenue of ~$3.5M observed in October 2025 (2) As of October 31, 2025; Source: CoinMarketCap

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Hyperion DeFi© 2025 6 Hyperliquid's (HYPE) Trading Platform Is Experiencing Rapid Adoption And Growth Hyperliquid Cryptocurrency Market Cap Ranking #11 Hyperliquid Market Cap ~$14.3 Billion Daily Trading Volume on Hyperliquid $12 Billion Hyperliquid Circulating Token Supply ~337 Million Daily Hyperliquid Fees ~$3M to Hyperliquid ~$2M to Applications Hyperliquid Marketplace Users ~800,000 Hyperliquid Maximum Token Supply 1 Billion Top Front - ends (& 30 - day Rev): Based ($10M) Phantom ($9M) pvp.trade ($8M) Hyperliquid Cryptocurrency Daily Revenue Ranking #1 Source: Flowscan Source: Hyperliquid Stats Source: Defi Llama Source: Defi Llama Source: CoinMarketCap Source: CoinMarketCap Source: CoinMarketCap Source: CoinMarketCap Source: Artemis As of October 31, 2025

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Hyperion DeFi© 2025 7 Hyperliquid's Parabolic Growth Hyperliquid has become the leading platform for on - chain derivatives, seen through its rapidly growing fees and crypto perpetuals ("perp") trading volume expansion since its Token Genesis Event in November 2024. Source: Defi Llama Key Metrics Total Value Locked App Fees (24h) Crypto Spot Volume (24h) Perps Volume (24h) Open Interest $HYPE Price $HYPE Market Cap $HYPE Fully Diluted Value $4.89b $4.97m $433.7m $11.905b $9.311b $42.59 $14.34b $42.596b >$3 Trillion CUMULATIVE PERP VOLUME Hyperliquid (HYPE) As of October 31, 2025 >$700 Million CUMULATIVE HYPERLIQUID FEES

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Hyperion DeFi© 2025 8 Early Mover Advantages Create Unique Opportunities for Compounding Revenue Streams (June through October 2025) Hyperliquid Staking Yield Validator Commissions Hyperliquid Staking Yield Hyperliquid Staking Yield Validator Commissions Yield Enhancement Validator Commissions Yield Enhancement Hyperliquid Staking Yield DeFi Monetization Validator Commissions Yield Enhancement Hyperliquid Staking Yield DeFi Monetization Ecosystem Rewards HAUS Credo Execution HAUS Felix Execution Co - Branded Kinetiq Validator RETURNS HYPERION DEFI'S RAPIDLY COMPOUNDING DEFI STRATEGY Launched " HiHYPE " Liquid Staking Token Received 3M Foundation HYPE Delegation June October Native Markets Partnership

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Hyperion DeFi© 2025 9 Hyperion DeFi stakes and deploys HYPE into the Hyperliquid Ecosystem Clients unlock unique utility on Hyperliquid ; Hyperion DeFi earns fees from Clients Client activity promotes broader Hyperliquid adoption Hyperion earns Validator Commissions and Ecosystem Rewards Hyperion DeFi reinvests revenues to purchase more HYPE How HYPD Drives the Institutional Adoption Flywheel • Reduced Trading Fees (Credo) • Launch of New "HIP3" Financial Markets (Felix) • Enable Native Markets' USDH "Aligned Stablecoin" 1 2 3 4 5 • Eligible for KNTQ

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Hyperion DeFi© 2025 10 Hyperion DeFi's validator has over 13M HYPE and is a top 10 validator We achieved 60% staked token growth in October, up from 8M in September As of October 31, 2025 Source: hyperliquid.xyz

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Hyperion DeFi© 2025 11 GAAP to Non - GAAP Reconciliation

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Hyperion DeFi© 2025 12 Non - GAAP Financial Measures In addition to our results determined in accordance with GAAP, this presentation and the accompanying tables contain Adjusted Re venue, Gross HYPE Holdings, Net Asset Value, and Adjusted EBITDA, which are non - GAAP financial measures. Adjusted Revenue, Gross HYPE Holdings, Net Asset Value, and Adjusted EBITDA are unaudited, presented as s upp lemental disclosure, and should not be considered in isolation or as a substitute for, or superior to, the financial information prepared and presented in accordance with GAAP. Please see page 13 for a reconciliation of Revenue to Adjusted Revenue during the three months ended September 30, 2025. Plea se see page 14 for a reconciliation of HYPE - Digital Assets to Gross HYPE Holdings as of September 30, 2025. Please see page 15 for a reconciliation of HYPE - Digital Assets to Net Asset Value as of September 30, 2025. Please s ee page 16 for a reconciliation of Net Income to Adjusted EBITDA during the three months ended September 30, 2025. It is important to note that the particular items we exclude from, or include in, Adjusted Revenue, Gross HYPE Holdings, Net Ass et Value, and Adjusted EBITDA may differ from the items excluded from, or included in, similar non - GAAP financial measures used by other companies in the same industry. We also periodically review our non - GAAP financial measure s and may revise these measures to reflect changes in our business or otherwise. "Adjusted Revenue" reflects all staking, commissions, and gross operational, asset - generating business activity in - period. It is reconciled to the GAAP measure "Revenue" by adding accumulated but unrealized rewards on HiHYPE . Staking rewards are not recognized from a GAAP Revenue perspective on our liquid staking token; instead, conversion back fr om HiHYPE into HYPE may result in a gain in connection with recognizing the market value of HYPE (including earned staking rewards) versus derecognizing the carrying value of HiHYPE upon conversion. We believe Adjusted Revenue provides a more complete view of our staking activities and overall recurring bu si ness profile, without potential period - to - period variability due to HiHYPE liquid staking activities. As such, Adjusted Revenue is an important metric used by our management for financial, risk manage me nt and operational decision - making, and provides an additional tool for investors to use to understand and compare our operating results across accountin g p eriods. "Gross HYPE Holdings" is the gross market value of the Company's HYPE assuming all HiHYPE tokens were converted back to HYPE tokens as of September 30, 2025. It is reconciled to the GAAP measure "HYPE - Digital Assets " by adding (i) HiHYPE Tokens at carrying value and (ii) the unrealized accretion (dilution) expected upon HiHYPE to HYPE reconversion as of September 30, 2025. We believe Gross HYPE Holdings is a helpful non - GAAP financial measure to our management and investors because it eliminates the temporary financial impacts caused by the conversion of HYP E t okens into HiHYPE tokens, which (a) derecognizes staking rewards and commissions on our HiHYPE tokens and (b) does not recognize upward mark - to - market movements in underlying HYPE tokens given HiHYPE is carried at the lower of cost basis or impaired value. As such, it provides useful information about our balance sheet, allows for greater transparency with respect to important metrics used by our management for financial, risk m ana gement and operational decision - making, and provides an additional tool for investors to use to understand and compare our operating results across accounting periods. "Net Asset Value" is the market value of our marketable digital assets less net outstanding debt. It is reconciled to the GAA P m easure "HYPE - Digital Assets" by (i) adding HiHYPE Tokens at carrying value, (ii) adding the unrealized accretion (dilution) expected upon HiHYPE to HYPE reconversion, (iii) adding Current Assets, (iv) subtracting Current Liabilities, and (v) subtracting Notes Payable (N on - current portion, without subtracting corresponding debt discounts or any unamortized issuance expenses). We believe Net Asset Value is a helpful non - GAAP financial measure to our manag ement and investors because it provides a more complete picture of our net liquid and marketable assets. It does not include Other Digital Assets which may not be immediately marketable. It does not include othe r n on - current assets or non - current liabilities beyond the aforementioned items. The Company believes "Net Asset Value provides useful information about our balance sheet and financial performance, enhances the overall understa ndi ng of our past performance and future prospects, allows for greater transparency with respect to important metrics used by our management for financial, risk management and operational decision - making, and provides an additio nal tool for investors to use to understand and compare our operating results across accounting periods. "Adjusted EBITDA" is a financial earnings measure meant to reflect management's view of recurring business activities and a m ore comparable view of the mark - to - market impacts on our digital asset treasury holdings in - period. It is reconciled to the GAAP measure "Net Income (Loss)" by removing (i) equity based compensation, (ii) interest expense, (iii) income taxes, (iv) depreciation and amortization expense (excluding am ortization of operating lease), (v) non - recurring gains from reductions in life sciences liabilities, and (vi) other non - recurring items which we do not consider ma terial in nature; and, it adds the in - period change in unrealized accretion (dilution) expected upon HiHYPE to HYPE reconversion. The items excluded from our Adjusted EBITDA are excluded because they are non - cash in nature, or because the amount and timing of these items are unpredictable, are not driven by core results of operations, and render comparisons with prior periods and competitors less meaningful. We add to Adjusted EBITDA the in - period c hange in unrealized accretion (dilution) expected upon HiHYPE to HYPE reconversion to give a more complete picture of mark - to - market impacts on our HYPE holdings, disregarding the temporary conversion of HYPE to HiHYPE . Adjusted EBITDA is used by management, in addition to GAAP financial measures, to understand and compare our operating results across accounting periods, for risk management and operational decision - making purposes. This non - GAAP measure provides investors with additional information in evaluating the Company's operating performance. Investors are cautioned that there are material limitations associated with the use of non - GAAP financial measures as an analyti cal tool.

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Hyperion DeFi© 2025 13 Reconciliation of Adjusted Revenue (unaudited) (1) Represents staking rewards on staked HYPE tokens which have been derecognized and converted into HiHYPE , which is Hyperion DeFi's liquid staking token. Staking rewards are not recognized from a GAAP Revenue perspective on our HiHYPE ; instead, conversion back from HiHYPE into HYPE may result in a gain in connection with recognizing the market value of HYPE (including earned staking rewards) versus d ere cognizing the carrying value of HiHYPE upon conversion. For the Three Months Ended September 30, 2025 $302,506 Revenue 58,771 Add: Accumulated but unrealized staking rewards on HiHYPE (1) $361,277 Adjusted Revenue

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Hyperion DeFi© 2025 14 September 30, 2025 Token Price Token Count Value $$45.19 839,889 $37,954,590 HYPE - Digital Assets Add: $39.74 877,871 34,884,932 HiHYPE Tokens at Carrying Value N.M. 2,788 4,912,082 Unrealized accretion (dilution) upon future HiHYPE to HYPE Token Conversion (1) $77,751,604 Gross HYPE Holdings $45.19 1,720,549 Gross HYPE Tokens (3) $4,912,082 Memo: In - Period Change in unrealized accretion (dilution) expected upon HiHYPE to HYPE reconversion (2) (1) Represents the estimated future financial implications if all company - owned HiHYPE tokens were reconverted to HYPE as of September 30, 2025. Encapsulates both the conversion of HiHYPE to HYPE plus the realization of previously accrued but unrecognized staking rewards. (2) Represents the change in "Unrealized accretion (dilution) upon future HiHYPE to HYPE reconversion" versus June 30, 2025. The Company did not hold any HiHYPE tokens on or prior to June 30, 2025. (3) Unaudited supplemental disclosure. Reconciliation of Gross HYPE Holdings (unaudited) And, supplemental reconciliation of Gross HYPE Tokens (3)

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Hyperion DeFi© 2025 15 September 30, 2025 Value $$37,954,590 HYPE - Digital Assets 34,884,932 Add: HiHYPE Tokens at Carrying Value 4,912,082 Add: Unrealized accretion (dilution) expected upon HiHYPE to HYPE reconversion 9,085,767 Add: Current Assets (4,037,092) Subtract: Current Liabilities (8,254,696) Subtract: Notes Payable (1) $74,545,583 Net Asset Value (1) Non - current portion; does not subtract debt discount of $598,691 as of September 30, 2025. Reconciliation of Net Asset Value (unaudited)

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Hyperion DeFi© 2025 16 (1) Does not include Amortization of Operating Lease. (2) Gain on extinguishment of liability and a reduction in accrued liability within other income was $2.2 million and $0.2 mi lli on respectively, combined totaling $2.4 million. (3) Includes gains on sales of equipment, release of reserves held against potential returns of company - sold items, and a one - ti me realized payment in connection with a terminated LOI. For the Three Months Ended September 30, 2025 $6,625,582 Net Income (Loss) Add back: (1,347,031) Equity based compensation 223,080 Interest expense - Income taxes - Depreciation and amortization expense (1) (2,407,154) Reductions in life sciences liabilities (2) (55,557) Other Non - Recurring Items (3) 4,912,082 Add: In - Period Change in unrealized accretion (dilution) expected upon HiHYPE to HYPE reconversion $7,951,004 Adjusted EBITDA Reconciliation of Adjusted EBITDA (unaudited)

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Hyperion DeFi© 2025 17 Frictionless exposure to Hyperliquid's native token HYPE. Access next - generation Decentralized Finance (DeFi). Bridging public markets and on - chain strategies. More than just HYPE. NASDAQ: HYPD