# EDGAR Filing Document

**Accession Number:** 0001984086
**File Stem:** 0001193125-26-290649
**Filing Date:** 2026-6
**Character Count:** 5669
**Document Hash:** 80ac9f92e9d8d27ceb8a8175683f38fb
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-26-290649.hdr.sgml**: 20260630

**ACCESSION NUMBER**: 0001193125-26-290649

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 9

**CONFORMED PERIOD OF REPORT**: 20260626

**ITEM INFORMATION**: Submission of Matters to a Vote of Security Holders

**FILED AS OF DATE**: 20260630

**DATE AS OF CHANGE**: 20260630

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Septerna, Inc.
- **CENTRAL INDEX KEY:** 0001984086
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 843891440
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-42382
- **FILM NUMBER:** 261140933

**BUSINESS ADDRESS:**
- **STREET 1:** 250 EAST GRAND AVENUE, SUITE 65
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080
- **BUSINESS PHONE:** 650-338-3533

**MAIL ADDRESS:**
- **STREET 1:** 250 EAST GRAND AVENUE, SUITE 65
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080

?xml version='1.0' encoding='ASCII'? 8-K

**UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549**

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## FORM 8-K

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**CURRENT REPORT**

**Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934**

**Date of Report (Date of earliest event reported):** June 26, 2026<br>

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Septerna, Inc.

**(Exact name of Registrant as Specified in Its Charter)**

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| | | |
|:---|:---|:---|
| Delaware | 001-42382 | 84-3891440 |
| **(State or Other Jurisdiction<br>of Incorporation)** | **(Commission File Number)** | **(IRS Employer<br>Identification No.)** |
| 250 East Grand Avenue |  |  |
| South San Francisco**,** California |  | 94080 |
| **(Address of Principal Executive Offices)** |  | **(Zip Code)** |

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**Registrant's Telephone Number, Including Area Code:** 650 338-3533<br>

Not Applicable

**(Former Name or Former Address, if Changed Since Last Report)**

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Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

**Securities registered pursuant to Section 12(b) of the Act:**

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| | | |
|:---|:---|:---|
| **<br>Title of each class** | **Trading<br>Symbol(s)** | **<br>Name of each exchange on which registered** |
| Common Stock, par value $0.001 per share | SEPN | The Nasdaq Global Market |

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Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging growth company ☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

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## Item 5.07 Submission of Matters to a Vote of Security Holders.
The following is a summary of the matters voted on at the 2026 annual meeting of stockholders of Septerna, Inc. (the "Company"), held on June 26, 2026 (the "Annual Meeting").

<u>Proposal No. 1</u>

The Company's stockholders elected Shalini Sharp, M.B.A. and Jake Simson, Ph.D. to the Company's Board of Directors (the "Board") as Class II directors, each for a three-year term ending at the annual meeting of stockholders of the Company to be held in 2029 and each until his or her respective successor has been duly elected and qualified or until his or her earlier death, resignation or removal. The results of the stockholders' vote with respect to the election of the Class II directors were as follows:

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| | | | |
|:---|:---|:---|:---|
| &nbsp;&nbsp;**CLASS II DIRECTOR NOMINEE** | &nbsp;&nbsp;**VOTES FOR** | &nbsp;&nbsp;**VOTES WITHHELD**  | &nbsp;&nbsp;**BROKER NON-VOTES** |
| &nbsp;&nbsp;Shalini Sharp, M.B.A. | &nbsp;&nbsp;33732317 | &nbsp;&nbsp;5808264 | &nbsp;&nbsp;1969475 |
| &nbsp;&nbsp;Jake Simson, Ph.D. | &nbsp;&nbsp;33716857 | &nbsp;&nbsp;5823724 | &nbsp;&nbsp;1969475 |

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<u>Proposal No. 2</u>

The Company's stockholders ratified the appointment of Ernst & Young LLP as the Company's independent registered public accounting firm for the fiscal year ending December 31, 2026. The results of the stockholders' vote with respect to such ratification were as follows:

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| | | | |
|:---|:---|:---|:---|
| &nbsp;&nbsp;**VOTES FOR** | &nbsp;&nbsp;**VOTES AGAINST** | &nbsp;&nbsp;**ABSTAIN** | &nbsp;&nbsp;**BROKER NON-VOTES** |
| &nbsp;&nbsp;41,207,237 | &nbsp;&nbsp;4,008 | &nbsp;&nbsp;298,811 | &nbsp;&nbsp;0 |

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No other matters were submitted to or voted on by the Company's stockholders at the Annual Meeting.

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**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

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| | | | |
|:---|:---|:---|:---|
|  |  |  | Septerna, Inc. |
| Date: | June 30, 2026 | By:  | /s/ Jeffrey Finer, M.D., Ph.D. |
|  |  |  | Jeffrey Finer, M.D., Ph.D<br>Chief Executive Officer |

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