# EDGAR Filing Document

**Accession Number:** 0001232621
**File Stem:** 0001214659-23-002405
**Filing Date:** 2023-2
**Character Count:** 12827
**Document Hash:** 3344af8f030d135beabf08c9ac6ad943
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001214659-23-002405.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001214659-23-002405

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**EFFECTIVENESS DATE**: 20230214

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** TANG CAPITAL MANAGEMENT LLC
- **CENTRAL INDEX KEY:** 0001232621
- **IRS NUMBER:** 461592449
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-14822
- **FILM NUMBER:** 23628417

**BUSINESS ADDRESS:**
- **STREET 1:** 4747 EXECUTIVE DRIVE
- **STREET 2:** SUITE 210
- **CITY:** SAN DIEGO
- **STATE:** CA
- **ZIP:** 92121
- **BUSINESS PHONE:** 858-200-3830

**MAIL ADDRESS:**
- **STREET 1:** 4747 EXECUTIVE DRIVE
- **STREET 2:** SUITE 210
- **CITY:** SAN DIEGO
- **STATE:** CA
- **ZIP:** 92121

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2022

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** TANG CAPITAL MANAGEMENT LLC<br>**Address:** 4747 Executive Drive<br>Suite 210<br>San Diego, CA 92121

**Form 13F File Number:** 028-14822

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Kevin Tang<br>**Title:** Manager<br>**Phone:** 858-200-3830

**Signature, Place, and Date of Signing:**

/s/ Kevin Tang  San Diego, CA  02-14-2023<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 1

**Form 13F Information Table Entry Total:** 89

**Form 13F Information Table Value Total:** $688313808

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

| No.   | Name         | Form 13F File Number   |
|:---|:---|:---|
|  | TANG KEVIN C | 028-14818              |

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| 2SEVENTY BIO INC | COMMON STOCK | 901384107 |  | 2342500 | 250000 | SH |  | OTR | 1 | 0 | 250000 | 0 |
| ACELRX PHARMACEUTICALS INC | COM NEW | 00444T209 |  | 440700 | 195000 | SH |  | OTR | 1 | 0 | 195000 | 0 |
| ADICET BIO INC | COM | 007002108 |  | 5364000 | 600000 | SH |  | OTR | 1 | 0 | 600000 | 0 |
| ALBIREO PHARMA INC | COM | 01345P106 |  | 8902628 | 411968 | SH |  | OTR | 1 | 0 | 411968 | 0 |
| ALDEYRA THERAPEUTICS INC | COM | 01438T106 |  | 1895159 | 272293 | SH |  | OTR | 1 | 0 | 272293 | 0 |
| ALIBABA GROUP HLDG LTD | SPONSORED ADS | 01609W102 |  | 4404500 | 50000 | SH |  | OTR | 1 | 0 | 50000 | 0 |
| ALIGOS THERAPEUTICS INC | COM | 01626L105 |  | 2683739 | 2816391 | SH |  | OTR | 1 | 0 | 2816391 | 0 |
| ALLAKOS INC | COM | 01671P100 |  | 3771882 | 447967 | SH |  | OTR | 1 | 0 | 447967 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 |  | 24953250 | 105000 | SH |  | OTR | 1 | 0 | 105000 | 0 |
| ALTIMMUNE INC | COM NEW | 02155H200 |  | 44422403 | 2700450 | SH |  | OTR | 1 | 0 | 2700450 | 0 |
| AMYLYX PHARMACEUTICALS INC | COM | 03237H101 |  | 3695000 | 100000 | SH |  | OTR | 1 | 0 | 100000 | 0 |
| ANAPTYSBIO INC | COM | 032724106 |  | 81462731 | 2628678 | SH |  | OTR | 1 | 0 | 2628678 | 0 |
| ARCUS BIOSCIENCES INC | COM | 03969F109 |  | 3058986 | 147920 | SH |  | OTR | 1 | 0 | 147920 | 0 |
| ARS PHARMACEUTICALS INC | COM | 82835W108 |  | 3492719 | 409463 | SH |  | OTR | 1 | 0 | 409463 | 0 |
| ARVINAS INC | COM | 04335A105 |  | 1026300 | 30000 | SH |  | OTR | 1 | 0 | 30000 | 0 |
| ASCENDIS PHARMA A/S | SPONSORED ADR | 04351P101 |  | 4407672 | 36090 | SH |  | OTR | 1 | 0 | 36090 | 0 |
| ASLAN PHARMACEUTICALS LTD | ADS | 04522R101 |  | 1931373 | 5364925 | SH |  | OTR | 1 | 0 | 5364925 | 0 |
| ASTRAZENECA PLC | SPONSORED ADR | 046353108 |  | 11526000 | 170000 | SH |  | OTR | 1 | 0 | 170000 | 0 |
| ATHIRA PHARMA INC | COM | 04746L104 |  | 1538192 | 485234 | SH |  | OTR | 1 | 0 | 485234 | 0 |
| ATYR PHARMA INC | COM NEW | 002120202 |  | 270312 | 123430 | SH |  | OTR | 1 | 0 | 123430 | 0 |
| AURINIA PHARMACEUTICALS INC | COM | 05156V102 |  | 864000 | 200000 | SH |  | OTR | 1 | 0 | 200000 | 0 |
| AXSOME THERAPEUTICS INC | COM | 05464T104 |  | 24681600 | 320000 | SH |  | OTR | 1 | 0 | 320000 | 0 |
| BEAM THERAPEUTICS INC | COM | 07373V105 |  | 3715450 | 95000 | SH |  | OTR | 1 | 0 | 95000 | 0 |
| BEIGENE LTD | SPONSORED ADR | 07725L102 |  | 18694900 | 85000 | SH |  | OTR | 1 | 0 | 85000 | 0 |
| BIO RAD LABS INC | CL A | 090572207 |  | 8830290 | 21000 | SH |  | OTR | 1 | 0 | 21000 | 0 |
| BIOATLA INC | COM | 09077B104 |  | 25773627 | 3124076 | SH |  | OTR | 1 | 0 | 3124076 | 0 |
| BIOCRYST PHARMACEUTICALS INC | COM | 09058V103 |  | 16646000 | 1450000 | SH |  | OTR | 1 | 0 | 1450000 | 0 |
| BIOHAVEN LTD | COM | G1110E107 |  | 1943200 | 140000 | SH |  | OTR | 1 | 0 | 140000 | 0 |
| BIONTECH SE | SPONSORED ADS | 09075V102 |  | 4506600 | 30000 | SH |  | OTR | 1 | 0 | 30000 | 0 |
| BLUEBIRD BIO INC | COM | 09609G100 |  | 32077854 | 4635528 | SH |  | OTR | 1 | 0 | 4635528 | 0 |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 |  | 1752400 | 40000 | SH |  | OTR | 1 | 0 | 40000 | 0 |
| BOLT BIOTHERAPEUTICS INC | COM | 097702104 |  | 520000 | 400000 | SH |  | OTR | 1 | 0 | 400000 | 0 |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 |  | 944527 | 21192 | SH |  | OTR | 1 | 0 | 21192 | 0 |
| COHERUS BIOSCIENCES INC | COM | 19249H103 |  | 917928 | 115900 | SH |  | OTR | 1 | 0 | 115900 | 0 |
| CONCERT PHARMACEUTICALS INC | COM | 206022105 |  | 6716000 | 1150000 | SH |  | OTR | 1 | 0 | 1150000 | 0 |
| CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 |  | 406500 | 10000 | SH |  | OTR | 1 | 0 | 10000 | 0 |
| CTI BIOPHARMA CORP | COM | 12648L601 |  | 1803000 | 300000 | SH |  | OTR | 1 | 0 | 300000 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 5040200 | 110000 | SH |  | OTR | 1 | 0 | 110000 | 0 |
| CYTOMX THERAPEUTICS INC | COM | 23284F105 |  | 5616712 | 3510445 | SH |  | OTR | 1 | 0 | 3510445 | 0 |
| CULLINAN ONCOLOGY INC | COM | 230031106 |  | 8537387 | 809231 | SH |  | OTR | 1 | 0 | 809231 | 0 |
| DYNAVAX TECHNOLOGIES CORP | COM NEW | 268158201 |  | 3192000 | 300000 | SH |  | OTR | 1 | 0 | 300000 | 0 |
| EAGLE PHARMACEUTICALS INC | COM | 269796108 |  | 3474190 | 118857 | SH |  | OTR | 1 | 0 | 118857 | 0 |
| ELEVATION ONCOLOGY INC | COM | 28623U101 |  | 455861 | 479854 | SH |  | OTR | 1 | 0 | 479854 | 0 |
| ENANTA PHARMACEUTICALS INC | COM | 29251M106 |  | 9304000 | 200000 | SH |  | OTR | 1 | 0 | 200000 | 0 |
| EVOLUS INC | COM | 30052C107 |  | 6079255 | 809488 | SH |  | OTR | 1 | 0 | 809488 | 0 |
| GALAPAGOS NV | SPON ADR | 36315X101 |  | 5101481 | 114950 | SH |  | OTR | 1 | 0 | 114950 | 0 |
| GENFIT S A | ADS | 372279109 |  | 5255924 | 1197522 | SH |  | OTR | 1 | 0 | 1197522 | 0 |
| GOSSAMER BIO INC | COM | 38341P102 |  | 217000 | 100000 | SH |  | OTR | 1 | 0 | 100000 | 0 |
| GRAPHITE BIO INC | COM | 38870X104 |  | 3652000 | 1100000 | SH |  | OTR | 1 | 0 | 1100000 | 0 |
| HARMONY BIOSCIENCES HLDGS IN | COM | 413197104 |  | 15494120 | 281200 | SH |  | OTR | 1 | 0 | 281200 | 0 |
| HEALTH SCIENCES ACQ CORP 2 | ORD SHS | G4411D109 |  | 3917150 | 392500 | SH |  | OTR | 1 | 0 | 392500 | 0 |
| HERON THERAPEUTICS INC | COM | 427746102 |  | 9389835 | 3755934 | SH |  | OTR | 1 | 0 | 3755934 | 0 |
| IMMUNOCORE HLDGS PLC | ADS | 45258D105 |  | 23147592 | 405600 | SH |  | OTR | 1 | 0 | 405600 | 0 |
| IMMUNOGEN INC | COM | 45253H101 |  | 6323271 | 1274853 | SH |  | OTR | 1 | 0 | 1274853 | 0 |
| INSMED INC | COM PAR $.01 | 457669307 |  | 3320736 | 166203 | SH |  | OTR | 1 | 0 | 166203 | 0 |
| INTRA-CELLULAR THERAPIES INC | COM | 46116X101 |  | 12700800 | 240000 | SH |  | OTR | 1 | 0 | 240000 | 0 |
| IONIS PHARMACEUTICALS INC | COM | 462222100 |  | 7554000 | 200000 | SH |  | OTR | 1 | 0 | 200000 | 0 |
| ITEOS THERAPEUTICS INC | COM | 46565G104 |  | 4232151 | 216700 | SH |  | OTR | 1 | 0 | 216700 | 0 |
| KALVISTA PHARMACEUTICALS INC | COM | 483497103 |  | 21607975 | 3196446 | SH |  | OTR | 1 | 0 | 3196446 | 0 |
| KINIKSA PHARMACEUTICALS LTD | COM CL A | G5269C101 |  | 8988000 | 600000 | SH |  | OTR | 1 | 0 | 600000 | 0 |
| LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 |  | 2995200 | 60000 | SH |  | OTR | 1 | 0 | 60000 | 0 |
| LIANBIO | SPONSORED ADS | 53000N108 |  | 97744 | 59600 | SH |  | OTR | 1 | 0 | 59600 | 0 |
| LILLY ELI  CO | COM | 532457108 |  | 7316800 | 20000 | SH |  | OTR | 1 | 0 | 20000 | 0 |
| METACRINE INC | COM | 59101E103 |  | 1903575 | 4250000 | SH |  | OTR | 1 | 0 | 4250000 | 0 |
| MIRATI THERAPEUTICS INC | COM | 60468T105 |  | 2718600 | 60000 | SH |  | OTR | 1 | 0 | 60000 | 0 |
| MIRUM PHARMACEUTICALS INC | COM | 604749101 |  | 21840000 | 1120000 | SH |  | OTR | 1 | 0 | 1120000 | 0 |
| MODERNA INC | COM | 60770K107 |  | 14369600 | 80000 | SH |  | OTR | 1 | 0 | 80000 | 0 |
| MOLECULAR PARTNERS AG | ADS | 60853G106 |  | 144100 | 22000 | SH |  | OTR | 1 | 0 | 22000 | 0 |
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 |  | 2579997 | 245714 | SH |  | OTR | 1 | 0 | 245714 | 0 |
| NEKTAR THERAPEUTICS | COM | 640268108 |  | 371069 | 164190 | SH |  | OTR | 1 | 0 | 164190 | 0 |
| NKARTA INC | COM | 65487U108 |  | 11201300 | 1870000 | SH |  | OTR | 1 | 0 | 1870000 | 0 |
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 |  | 781369 | 318926 | SH |  | OTR | 1 | 0 | 318926 | 0 |
| ORCHARD THERAPEUTICS PLC | SPON ADS | 68570P101 |  | 742000 | 2000000 | SH |  | OTR | 1 | 0 | 2000000 | 0 |
| PARDES BIOSCIENCES INC | COM | 69945Q105 |  | 57034 | 33748 | SH |  | OTR | 1 | 0 | 33748 | 0 |
| PYXIS ONCOLOGY INC | COMMON STOCK | 747324101 |  | 4650738 | 3470700 | SH |  | OTR | 1 | 0 | 3470700 | 0 |
| RELMADA THERAPEUTICS INC | COM | 75955J402 |  | 349000 | 100000 | SH |  | OTR | 1 | 0 | 100000 | 0 |
| RENEO PHARMACEUTICALS INC | COM | 75974E103 |  | 71268 | 30587 | SH |  | OTR | 1 | 0 | 30587 | 0 |
| REVIVA PHARMACEUTCLS HLDGS I | COM | 76152G100 |  | 102531 | 24125 | SH |  | OTR | 1 | 0 | 24125 | 0 |
| SIO GENE THERAPIES INC | COM | 829399104 |  | 870000 | 2000000 | SH |  | OTR | 1 | 0 | 2000000 | 0 |
| SURFACE ONCOLOGY INC | COM | 86877M209 |  | 352311 | 429647 | SH |  | OTR | 1 | 0 | 429647 | 0 |
| TARSUS PHARMACEUTICALS INC | COM | 87650L103 |  | 29343236 | 2001585 | SH |  | OTR | 1 | 0 | 2001585 | 0 |
| TCR2 THERAPEUTICS INC | COM | 87808K106 |  | 2735660 | 2738947 | SH |  | OTR | 1 | 0 | 2738947 | 0 |
| THIRD HARMONIC BIO INC | COM | 88427A107 |  | 7310000 | 1700000 | SH |  | OTR | 1 | 0 | 1700000 | 0 |
| TONIX PHARMACEUTICALS HLDG C | COM NEW | 890260862 |  | 1754263 | 4500419 | SH |  | OTR | 1 | 0 | 4500419 | 0 |
| TSCAN THERAPEUTICS INC | COM | 89854M101 |  | 797715 | 514655 | SH |  | OTR | 1 | 0 | 514655 | 0 |
| VAXCYTE INC | COM | 92243G108 |  | 14385000 | 300000 | SH |  | OTR | 1 | 0 | 300000 | 0 |
| VINCERX PHARMA INC | COM NEW | 92731L106 |  | 103797 | 101762 | SH |  | OTR | 1 | 0 | 101762 | 0 |
| VIRIDIAN THERAPEUTICS INC | COM | 92790C104 |  | 20240339 | 692925 | SH |  | OTR | 1 | 0 | 692925 | 0 |
| ZYMEWORKS DEL INC | COM | 98985Y108 |  | 3144000 | 400000 | SH |  | OTR | 1 | 0 | 400000 | 0 |

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