# EDGAR Filing Document

**Accession Number:** 0000872625
**File Stem:** 0001752724-25-153739
**Filing Date:** 2025-6
**Character Count:** 37940
**Document Hash:** 71ad1e1939d006d1b1298374bce784d0
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001752724-25-153739.hdr.sgml**: 20250624

**ACCESSION NUMBER**: 0001752724-25-153739

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20250430

**FILED AS OF DATE**: 20250624

**DATE AS OF CHANGE**: 20250624

**PERIOD START**: 20250430

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** FRANKLIN STRATEGIC SERIES
- **CENTRAL INDEX KEY:** 0000872625

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** FL
- **FISCAL YEAR END:** 0430

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-06243
- **FILM NUMBER:** 251068701

**BUSINESS ADDRESS:**
- **STREET 1:** ONE FRANKLIN PARKWAY
- **CITY:** SAN MATEO
- **STATE:** CA
- **ZIP:** 94403-1906
- **BUSINESS PHONE:** 650-570-3000

**MAIL ADDRESS:**
- **STREET 1:** ONE FRANKLIN PARKWAY
- **CITY:** SAN MATEO
- **STATE:** CA
- **ZIP:** 94403-1906

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** FRANKLIN CALIFORNIA 250 GROWTH FUND
- **DATE OF NAME CHANGE:** 19911216

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** FRANKLIN CALIFORNIA 250 GROWTH INDEX FUND
- **DATE OF NAME CHANGE:** 19910917

## Series and Classes Contracts Data

### FRANKLIN BIOTECHNOLOGY DISCOVERY FUND (Series ID: S000006882)

| Class ID   | Class Name    | Ticker Symbol   |
|:---|:---|:---|
| C000018631 | CLASS A       | FBDIX           |
| C000081539 | ADVISOR CLASS | FTDZX           |
| C000128862 | Class R6      | FRBRX           |
| C000141458 | Class C       | FBTDX           |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** Franklin Strategic Series

- **b. Investment Company Act file number:** 811-06243

- **c. CIK number of Registrant:** 0000872625

- **d. LEI of Registrant:** 549300NDWC0J6DXVSX36

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** One Franklin Parkway

  - **City:** San Mateo

  - **State:** CA

  - **Foreign country:** US

  - **Zip / Postal Code:** 94403-1906

  - **Telephone number:** 650-312-2000

**Item A.2. Information about the Series.**

- **a. Name of Series:** Franklin Biotechnology Discovery Fund

- **b. EDGAR series identifier (if any):** S000006882

- **c. LEI of Series:** 6N5133EDK315FXQQM036

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2025-04-30

- **b. Date as of which information is reported:** 2025-04-30

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $714891370.85

**Total Liabilities:** $7220931.46

**Net Assets:** $707670439.39

**Cash Not Reported:** $162710.48

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000128862 | -1.42%               | -5.90%               | 1.19%                |
| Class ID C000018631 | -1.44%               | -5.93%               | 1.16%                |
| Class ID C000081539 | -1.42%               | -5.91%               | 1.17%                |
| Class ID C000141458 | -1.50%               | -5.99%               | 1.09%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $5812521.55              | $-17873562.85                              |
| Month 2  | $-1472495.64             | $-43797507.90                              |
| Month 3  | $-2220251.57             | $9828620.70                                |

### Schedule of Portfolio Investments

| Name                                                   | Title                                                  | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Apogee Therapeutics, Inc.                              | Apogee Therapeutics, Inc.                              | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    155539 | NS      | $6104905.75   | 0.86%             |  |  |  | No            |                  1 | On Loan: No      |
| Solid Biosciences, Inc.                                | Solid Biosciences, Inc.                                | CUSIP: 83422E204<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    449300 | NS      | $1487183.00   | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| uniQure NV                                             | uniQure NV                                             | CUSIP: N/A<br>LEI: 724500RPCTZLFYJZ3S98       | Long             | EC               | CORP              | NL        |    696400 | NS      | $10278864.00  | 1.45%             |  |  |  | No            |                  1 | On Loan: No      |
| ORIC Pharmaceuticals, Inc.                             | ORIC Pharmaceuticals, Inc.                             | CUSIP: 68622P109<br>LEI: 54930033FJRNEYBW0L25 | Long             | EC               | CORP              | US        |    363283 | NS      | $2074345.93   | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Merus NV                                               | Merus NV                                               | CUSIP: N/A<br>LEI: 549300W8GPUWU8QNU293       | Long             | EC               | CORP              | NL        |    499698 | NS      | $22741255.98  | 3.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Jazz Pharmaceuticals plc                               | Jazz Pharmaceuticals plc                               | CUSIP: N/A<br>LEI: 635400GAUMJCLEZRRV50       | Long             | EC               | CORP              | IE        |    237159 | NS      | $27738116.64  | 3.92%             |  |  |  | No            |                  1 | On Loan: No      |
| Eli Lilly & Co.                                        | Eli Lilly & Co.                                        | CUSIP: 532457108<br>LEI: FRDRIPF3EKNDJ2CQJL29 | Long             | EC               | CORP              | US        |     19571 | NS      | $17593350.45  | 2.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Mineralys Therapeutics, Inc.                           | Mineralys Therapeutics, Inc.                           | CUSIP: 603170101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    645332 | NS      | $9170167.72   | 1.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences, Inc.                           | Neurocrine Biosciences, Inc.                           | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |    159830 | NS      | $17212092.70  | 2.43%             |  |  |  | No            |                  1 | On Loan: No      |
| Insmed, Inc.                                           | Insmed, Inc.                                           | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |    227140 | NS      | $16354080.00  | 2.31%             |  |  |  | No            |                  1 | On Loan: No      |
| Dyne Therapeutics, Inc.                                | Dyne Therapeutics, Inc.                                | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    288652 | NS      | $3403207.08   | 0.48%             |  |  |  | No            |                  1 | On Loan: No      |
| Zealand Pharma A/S                                     | Zealand Pharma A/S, Class A                            | CUSIP: N/A<br>LEI: 549300ITBB1ULBL4CZ12       | Long             | EC               | CORP              | DK        |     69700 | NS      | $4929611.70   | 0.70%             |  |  |  | No            |                  2 | On Loan: No      |
| Soleno Therapeutics, Inc.                              | Soleno Therapeutics, Inc.                              | CUSIP: 834203309<br>LEI: 5493003LCY77N7FXK844 | Long             | EC               | CORP              | US        |      9500 | NS      | $711170.00    | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Kura Oncology, Inc.                                    | Kura Oncology, Inc.                                    | CUSIP: 50127T109<br>LEI: 5493005QORQTZCZYOP39 | Long             | EC               | CORP              | US        |    281882 | NS      | $1849145.92   | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Sartorius Stedim Biotech                               | Sartorius Stedim Biotech                               | CUSIP: N/A<br>LEI: 52990006IVXY7GCSSR39       | Long             | EC               | CORP              | FR        |     10100 | NS      | $2383507.39   | 0.34%             |  |  |  | No            |                  2 | On Loan: No      |
| Sartorius AG                                           | Sartorius AG                                           | CUSIP: N/A<br>LEI: 529900EQV2DY4FOAMU38       | Long             | EP               | CORP              | DE        |      9200 | NS      | $2388269.79   | 0.34%             |  |  |  | No            |                  2 | On Loan: No      |
| Benitec Biopharma, Inc.                                | Benitec Biopharma, Inc.                                | CUSIP: 08205P209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1218454 | NS      | $16558789.86  | 2.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Argenx SE                                              | Argenx SE                                              | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |     44836 | NS      | $28925497.04  | 4.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Aura Biosciences, Inc.                                 | Aura Biosciences, Inc.                                 | CUSIP: 05153U107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    778636 | NS      | $4539447.88   | 0.64%             |  |  |  | No            |                  1 | On Loan: No      |
| Olema Pharmaceuticals, Inc.                            | Olema Pharmaceuticals, Inc.                            | CUSIP: 68062P106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     94989 | NS      | $490143.24    | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Candid, Inc.                                           | Candid, Inc., Series B                                 | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |   1519609 | NS      | $1275135.82   | 0.18%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Contineum Therapeutics, Inc.                           | Contineum Therapeutics, Inc., Class A                  | CUSIP: 21217B100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    276967 | NS      | $1138334.37   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Engene Holdings, Inc.                                  | Engene Holdings, Inc.                                  | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | CA        |    272359 | NS      | $1127566.26   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Praxis Precision Medicines, Inc.                       | Praxis Precision Medicines, Inc.                       | CUSIP: 74006W207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    113704 | NS      | $4279818.56   | 0.60%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytokinetics, Inc.                                     | Cytokinetics, Inc.                                     | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |     41200 | NS      | $1765008.00   | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Satellos Bioscience, Inc.                              | Satellos Bioscience, Inc.                              | CUSIP: 80401L308<br>LEI: 529900EN243BZ5QC9N39 | Long             | EC               | CORP              | CA        |   1161960 | NS      | $547855.80    | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Day One Biopharmaceuticals, Inc.                       | Day One Biopharmaceuticals, Inc.                       | CUSIP: 23954D109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    851469 | NS      | $6624428.82   | 0.94%             |  |  |  | No            |                  1 | On Loan: No      |
| Janux Therapeutics, Inc.                               | Janux Therapeutics, Inc.                               | CUSIP: 47103J105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    186502 | NS      | $6191866.40   | 0.87%             |  |  |  | No            |                  1 | On Loan: No      |
| Centessa Pharmaceuticals plc                           | Centessa Pharmaceuticals plc                           | CUSIP: 152309100<br>LEI: 213800GIDAARDSKOI827 | Long             | EC               | CORP              | GB        |    489229 | NS      | $6707329.59   | 0.95%             |  |  |  | No            |                  1 | On Loan: No      |
| Lycia LLC                                              | Lycia LLC, Series C                                    | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | JP        |    859370 | NS      | $1311980.41   | 0.19%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Xenon Pharmaceuticals, Inc.                            | Xenon Pharmaceuticals, Inc.                            | CUSIP: 98420N105<br>LEI: 549300XV44Q9Z1MIPQ03 | Long             | EC               | CORP              | CA        |     93364 | NS      | $3566504.80   | 0.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Cullinan Therapeutics, Inc.                            | Cullinan Therapeutics, Inc.                            | CUSIP: 230031106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    483951 | NS      | $4007114.28   | 0.57%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC Therapeutics, Inc.                                 | PTC Therapeutics, Inc.                                 | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |    440811 | NS      | $21970020.24  | 3.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Ultragenyx Pharmaceutical, Inc.                        | Ultragenyx Pharmaceutical, Inc.                        | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |     82007 | NS      | $3196632.86   | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvalent, Inc.                                         | Nuvalent, Inc., Class A                                | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     56254 | NS      | $4317494.50   | 0.61%             |  |  |  | No            |                  1 | On Loan: No      |
| Mirum Pharmaceuticals, Inc.                            | Mirum Pharmaceuticals, Inc.                            | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |    215190 | NS      | $9350005.50   | 1.32%             |  |  |  | No            |                  1 | On Loan: No      |
| Kyverna Therapeutics, Inc.                             | Kyverna Therapeutics, Inc.                             | CUSIP: 501976104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    244900 | NS      | $565719.00    | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| AstraZeneca plc                                        | AstraZeneca plc                                        | CUSIP: 046353108<br>LEI: PY6ZZQWO2IZFZC3IOL08 | Long             | EC               | CORP              | GB        |    205062 | NS      | $14721400.98  | 2.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Sarepta Therapeutics, Inc.                             | Sarepta Therapeutics, Inc.                             | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |     83578 | NS      | $5215267.20   | 0.74%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcutis Biotherapeutics, Inc.                          | Arcutis Biotherapeutics, Inc.                          | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    965545 | NS      | $14396275.95  | 2.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvation Bio, Inc.                                     | Nuvation Bio, Inc.                                     | CUSIP: 67080N119<br>LEI: N/A                  | Long             |  | CORP              | US        |    115266 | NS      | $28816.50     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Abivax SA                                              | Abivax SA                                              | CUSIP: 00370M103<br>LEI: 969500D8TMNB184OJU95 | Long             | EC               | CORP              | FR        |    497692 | NS      | $3543567.04   | 0.50%             |  |  |  | No            |                  1 | On Loan: —       |
| CG oncology, Inc.                                      | CG oncology, Inc.                                      | CUSIP: 156944100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    211553 | NS      | $5699237.82   | 0.81%             |  |  |  | No            |                  1 | On Loan: No      |
| MBX Biosciences, Inc.                                  | MBX Biosciences, Inc.                                  | CUSIP: 55287L101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    157251 | NS      | $1649562.99   | 0.23%             |  |  |  | No            |                  1 | On Loan: —       |
| Syndax Pharmaceuticals, Inc.                           | Syndax Pharmaceuticals, Inc.                           | CUSIP: 87164F105<br>LEI: 529900OF94TRHKZVBS87 | Long             | EC               | CORP              | US        |    462649 | NS      | $6546483.35   | 0.93%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals, Inc.                          | Alnylam Pharmaceuticals, Inc.                          | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |     57389 | NS      | $15107080.36  | 2.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Context Therapeutics, Inc.                             | Context Therapeutics, Inc.                             | CUSIP: 21077P108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1479200 | NS      | $1282466.40   | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Vaxcyte, Inc.                                          | Vaxcyte, Inc.                                          | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |    210139 | NS      | $7531381.76   | 1.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Ascendis Pharma A/S                                    | Ascendis Pharma A/S                                    | CUSIP: 04351P101<br>LEI: 549300B66JN3W3J8GH73 | Long             | EC               | CORP              | DK        |    203340 | NS      | $34657269.60  | 4.90%             |  |  |  | No            |                  1 | On Loan: No      |
| Oruka Therapeutics, Inc.                               | Oruka Therapeutics, Inc.                               | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |    249964 | NS      | $2609624.16   | 0.37%             |  |  |  | No            |                  1 | On Loan: —       |
| Newamsterdam Pharma Co. NV                             | Newamsterdam Pharma Co. NV                             | CUSIP: N/A<br>LEI: 984500B6549TF6E14D36       | Long             | EC               | CORP              | NL        |     92300 | NS      | $1765699.00   | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Crinetics Pharmaceuticals, Inc.                        | Crinetics Pharmaceuticals, Inc.                        | CUSIP: 22663K107<br>LEI: 549300Q1CNFXK5P31D28 | Long             | EC               | CORP              | US        |    228926 | NS      | $7643839.14   | 1.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Alector, Inc.                                          | Alector, Inc.                                          | CUSIP: 014442107<br>LEI: 549300Z8RQOIY1JMHC25 | Long             | EC               | CORP              | US        |    271025 | NS      | $325230.00    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Jade Biosciences, Inc.                                 | Jade Biosciences, Inc.                                 | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |    724637 | NS      | $6884051.50   | 0.97%             |  |  |  | No            |                  2 | On Loan: No      |
| Olema Pharmaceuticals, Inc.                            | Olema Pharmaceuticals, Inc.                            | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |    677200 | NS      | $3494352.00   | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| AnaptysBio, Inc.                                       | AnaptysBio, Inc.                                       | CUSIP: 032724106<br>LEI: 529900HH4WQT03IG1A12 | Long             | EC               | CORP              | US        |    128979 | NS      | $2865913.38   | 0.40%             |  |  |  | No            |                  1 | On Loan: No      |
| Alto Neuroscience, Inc.                                | Alto Neuroscience, Inc.                                | CUSIP: 02157Q109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    263900 | NS      | $657111.00    | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Structure Therapeutics, Inc.                           | Structure Therapeutics, Inc.                           | CUSIP: 86366E106<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |     34633 | NS      | $935091.00    | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Applied Therapeutics, Inc.                             | Applied Therapeutics, Inc.                             | CUSIP: 03828A101<br>LEI: 549300KL3IJPHZM2GR04 | Long             | EC               | CORP              | US        |    740200 | NS      | $302889.84    | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Vertex Pharmaceuticals, Inc.                           | Vertex Pharmaceuticals, Inc.                           | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |    111026 | NS      | $56567747.00  | 7.99%             |  |  |  | No            |                  1 | On Loan: No      |
| Cogent Biosciences, Inc.                               | Cogent Biosciences, Inc.                               | CUSIP: 19240Q201<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    481629 | NS      | $2509287.09   | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| ARS Pharmaceuticals, Inc.                              | ARS Pharmaceuticals, Inc.                              | CUSIP: 82835W108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    654375 | NS      | $9141618.75   | 1.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Jasper Therapeutics, Inc.                              | Jasper Therapeutics, Inc.                              | CUSIP: 471871202<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    195441 | NS      | $1072971.09   | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Artiva Biotherapeutics, Inc.                           | Artiva Biotherapeutics, Inc.                           | CUSIP: 04317A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    192871 | NS      | $460961.69    | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Carmot Therapeutics, Inc.                              | Carmot Therapeutics, Inc.                              | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |     83100 | NS      | $400031.43    | 0.06%             |  |  |  | No            |                  3 | On Loan: No      |
| Acumen Pharmaceuticals, Inc.                           | Acumen Pharmaceuticals, Inc.                           | CUSIP: 00509G209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    826400 | NS      | $933832.00    | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Institutional Fiduciary Trust Money Market Portfolio   | Institutional Fiduciary Trust Money Market Portfolio   | CUSIP: 8611239C3<br>LEI: N/A                  | Long             | STIV             | RF                | US        |   6432014 | NS      | $6432014.00   | 0.91%             |  |  |  | No            |                  1 | On Loan: No      |
| HilleVax, Inc.                                         | HilleVax, Inc.                                         | CUSIP: 43157M102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    691356 | NS      | $1341230.64   | 0.19%             |  |  |  | No            |                  1 | On Loan: —       |
| EyePoint Pharmaceuticals, Inc.                         | EyePoint Pharmaceuticals, Inc.                         | CUSIP: 30233G209<br>LEI: 549300QE1RU34T50MR69 | Long             | EC               | CORP              | US        |   1036629 | NS      | $7069809.78   | 1.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Bridgebio Pharma, Inc.                                 | Bridgebio Pharma, Inc.                                 | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |    118875 | NS      | $4560045.00   | 0.64%             |  |  |  | No            |                  1 | On Loan: No      |
| Spyre Therapeutics, Inc.                               | Spyre Therapeutics, Inc.                               | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |    220000 | NS      | $3350600.00   | 0.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Achieve Life Sciences, Inc.                            | Achieve Life Sciences, Inc.                            | CUSIP: 004468500<br>LEI: 549300V82ZKZDTAU0A46 | Long             | EC               | CORP              | US        |    897273 | NS      | $2332909.80   | 0.33%             |  |  |  | No            |                  1 | On Loan: No      |
| Centessa Pharmaceuticals plc                           | Centessa Pharmaceuticals plc                           | CUSIP: 152309100<br>LEI: 213800GIDAARDSKOI827 | Long             | EC               | CORP              | GB        |    189736 | NS      | $2601280.56   | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Amgen, Inc.                                            | Amgen, Inc.                                            | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |    179411 | NS      | $52194248.12  | 7.38%             |  |  |  | No            |                  1 | On Loan: No      |
| Avantor, Inc.                                          | Avantor, Inc.                                          | CUSIP: 05352A100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    383929 | NS      | $4987237.71   | 0.70%             |  |  |  | No            |                  1 | On Loan: No      |
| IN8bio, Inc.                                           | IN8bio, Inc.                                           | CUSIP: N/A<br>LEI: 549300H68IVCRKSGSL94       | Long             | EC               | CORP              | US        |   2090200 | NS      | $353243.80    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Spyre Therapeutics, Inc.                               | Spyre Therapeutics, Inc.                               | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |     53800 | NS      | $819374.00    | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Achieve Life Sciences, Inc.                            | Achieve Life Sciences, Inc.                            | CUSIP: N/A<br>LEI: 549300V82ZKZDTAU0A46       | Long             |  | CORP              | US        |   2181025 | NS      | $210671.75    | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| IN8bio, Inc.                                           | IN8bio, Inc., Series C                                 | CUSIP: N/A<br>LEI: 549300H68IVCRKSGSL94       | Long             |  | CORP              | US        |   2090200 | NS      | $79051.36     | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Regeneron Pharmaceuticals, Inc.                        | Regeneron Pharmaceuticals, Inc.                        | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |     59922 | NS      | $35878896.72  | 5.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Gilead Sciences, Inc.                                  | Gilead Sciences, Inc.                                  | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |    502212 | NS      | $53505666.48  | 7.56%             |  |  |  | No            |                  1 | On Loan: No      |
| CAMP4 Therapeutics Corp.                               | CAMP4 Therapeutics Corp.                               | CUSIP: 13463J101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    180166 | NS      | $318893.82    | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Thermo Fisher Scientific, Inc.                         | Thermo Fisher Scientific, Inc.                         | CUSIP: 883556102<br>LEI: HCHV7422L5HDJZCRFL38 | Long             | EC               | CORP              | US        |      8579 | NS      | $3680391.00   | 0.52%             |  |  |  | No            |                  1 | On Loan: No      |
| Guardant Health, Inc.                                  | Guardant Health, Inc.                                  | CUSIP: 40131M109<br>LEI: 254900M8C3E5VC8BR186 | Long             | EC               | CORP              | US        |    323366 | NS      | $15272576.18  | 2.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Structure Therapeutics, Inc.                           | Structure Therapeutics, Inc.                           | CUSIP: 86366E106<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |    159221 | NS      | $4298967.00   | 0.61%             |  |  |  | No            |                  1 | On Loan: No      |
| Institutional Fiduciary Trust - Money Market Portfolio | Institutional Fiduciary Trust - Money Market Portfolio | CUSIP: 457756500<br>LEI: 549300M4TP89K77LG374 | Long             | STIV             | RF                | US        |  17512045 | NS      | $17512045.22  | 2.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Sanofi SA                                              | Sanofi SA, Escrow Account                              | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | CO        |   2333755 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Contineum Therapeutics, Inc.                           | Contineum Therapeutics, Inc., Class A                  | CUSIP: 21217B100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    295058 | NS      | $1212688.38   | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Ocular Therapeutix, Inc.                               | Ocular Therapeutix, Inc.                               | CUSIP: 67576A100<br>LEI: 529900ABAWFXOHSIHG03 | Long             | EC               | CORP              | US        |    410100 | NS      | $3403830.00   | 0.48%             |  |  |  | No            |                  1 | On Loan: No      |
| Sionna Therapeutics, Inc.                              | Sionna Therapeutics, Inc.                              | CUSIP: 829401108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    181100 | NS      | $2178633.00   | 0.31%             |  |  |  | No            |                  1 | On Loan: —       |
| Benitec Biopharma, Inc.                                | Benitec Biopharma, Inc.                                | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |    310881 | NS      | $4224841.70   | 0.60%             |  |  |  | No            |                  2 | On Loan: No      |
| Alto Neuroscience, Inc.                                | Alto Neuroscience, Inc.                                | CUSIP: 02157Q109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    165070 | NS      | $411024.30    | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Engene Holdings, Inc.                                  | Engene Holdings, Inc.                                  | CUSIP: 29286M105<br>LEI: N/A                  | Long             | EC               | CORP              | CA        |    110478 | NS      | $457378.92    | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Akebia Therapeutics, Inc.                              | Akebia Therapeutics, Inc.                              | CUSIP: 00972D105<br>LEI: 549300CBQEHMKEEGNX42 | Long             | EC               | CORP              | US        |    895000 | NS      | $2156950.00   | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2025-05-30

**Name of Applicant:** Franklin Strategic Series

**Signature:** Monica Krogh

**Name of Signer:** Monica Krogh

**Title:** Assistant Treasurer