# EDGAR Filing Document

**Accession Number:** 0001847367
**File Stem:** 0001104659-25-079224
**Filing Date:** 2025-8
**Character Count:** 2743
**Document Hash:** 30c2ba557ba3e436dfbcc80ad46675e5
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-25-079224.hdr.sgml**: 20250917

**ACCESSION NUMBER**: 0001104659-25-079224

**CONFORMED SUBMISSION TYPE**: CORRESP

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20250815

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** ALUMIS INC.
- **CENTRAL INDEX KEY:** 0001847367
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** CORRESP

**BUSINESS ADDRESS:**
- **STREET 1:** 280 EAST GRAND AVENUE
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080
- **BUSINESS PHONE:** 650-231-6625

**MAIL ADDRESS:**
- **STREET 1:** 280 EAST GRAND AVENUE
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ESKER THERAPEUTICS, INC.
- **DATE OF NAME CHANGE:** 20230427

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** FL2021-001, Inc.
- **DATE OF NAME CHANGE:** 20210222

**ALUMIS INC.**

280 East Grand Avenue

South San Francisco, CA 94080

(650) 231-6625

August 15, 2025

***Via EDGAR***

U.S. Securities and Exchange Commission

Division of Corporation Finance

Office of Life Sciences

100 F Street, N.E.

Washington, D.C. 20549

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| | |
|:---|:---|
| Re: | **Alumis Inc.** |
|  | **Registration Statement on Form S-3** |
|  | **Filed July 3, 2025** |
|  | **File No. 333-288510** |

---

Ladies and Gentlemen:

In accordance with Rule 461 under the Securities Act of 1933, as amended, the undersigned registrant (the "***Registrant***") hereby requests that the U.S. Securities and Exchange Commission (the "***Commission***") take appropriate action to cause the Registration Statement on Form S-3 (File No. 333-288510) (the "***Registration Statement***") to become effective on Tuesday, August 19, 2025, at 4:00 p.m., Eastern Time, or as soon as practicable thereafter, or at such later time as the Registrant may orally request via telephone call to the staff of the Commission. The Registrant hereby authorizes Chadwick Mills of Cooley LLP, counsel to the Registrant, to make such request on its behalf.

Once the Registration Statement has been declared effective, please orally confirm that event with Chadwick Mills of Cooley LLP, counsel to the Registrant, at (650) 843-5654, or in his absence Christine Turner of Cooley LLP at (720) 566-4163.

Very truly yours,

---

| | |
|:---|:---|
| **ALUMIS INC.** | **ALUMIS INC.** |
| By: | /s/ Martin Babler |
| Name: | Martin Babler |
| Title: | President & Chief Executive Officer |

---

cc: Kristin VanderPas, Cooley LLP

Chadwick Mills, Cooley LLP

Christine Turner, Cooley LLP