# EDGAR Filing Document

**Accession Number:** 0001815620
**File Stem:** 0001193125-25-273380
**Filing Date:** 2025-11
**Character Count:** 5885
**Document Hash:** ed24ecc04aa17aa8fea7895696320e97
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-25-273380.hdr.sgml**: 20251110

**ACCESSION NUMBER**: 0001193125-25-273380

**CONFORMED SUBMISSION TYPE**: S-8 POS

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20251110

**DATE AS OF CHANGE**: 20251110

**EFFECTIVENESS DATE**: 20251110

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Opthea Ltd
- **CENTRAL INDEX KEY:** 0001815620
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** C3
- **FISCAL YEAR END:** 0630

**FILING VALUES:**
- **FORM TYPE:** S-8 POS
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-251052
- **FILM NUMBER:** 251464624

**BUSINESS ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** LEVEL 4
- **STREET 2:** 650 CHAPEL STREET
- **CITY:** SOUTH YARRA
- **NON US STATE TERRITORY:** VICTORIA
- **PROVINCE COUNTRY:** C3
- **ZIP:** 3141
- **BUSINESS PHONE:** 61 3 9826 0399

**MAIL ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** LEVEL 4
- **STREET 2:** 650 CHAPEL STREET
- **CITY:** SOUTH YARRA
- **NON US STATE TERRITORY:** VICTORIA
- **PROVINCE COUNTRY:** C3
- **ZIP:** 3141

**As filed with the Securities and Exchange Commission on November 10, 2025** 

**Registration No. 333-251052** 

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**Washington, D.C. 20549** 

**POST EFFECTIVE AMENDMENT NO. 1 TO** 

**FORM S-8** 

**REGISTRATION STATEMENT** 

***UNDER***

***THE SECURITIES ACT OF 1933***

## OPTHEA LIMITED
**(Exact name of registrant as specified in its charter)** 

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| | |
|:---|:---|
| **Australia** | **Not Applicable** |
| **(State or other jurisdiction of**<br> **incorporation or organization)** | **(I.R.S. Employer**<br> **Identification Number)** |

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**C/- Prime Company Compliance, Level 9** 

**505 Little Collins Street** 

**Melbourne, VIC 3000** 

**Australia** 

**+ 61 3 9826 0399** 

**(Address, including zip code, and telephone number, including area code, of registrant's principal executive offices)** 

**Opthea Limited –Long-Term Incentive Plan** 

**Opthea Limited – Non-Executive Director Share and Option Plan** 

**(Full title of the plans)** 

**Corporation Service Company** 

**19 West 44th Street, Suite 200** 

**New York, New York 10036** 

**(800) 927-9800**

**(Name, address, including zip code, and telephone number, including area code, of agent for service)** 

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.

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| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☐ | Accelerated filer | ☐ |
| Non-accelerated filer | ☒ | Smaller reporting company | ☐ |
|  |  | Emerging growth company | ☒ |

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If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

***Copies to:***

**Ferish Patel** 

**Milson Yu** 

**Cooley LLP** 

**182 Cecil Street, Level 38** 

**Frasers Tower** 

**Singapore 069547** 

**+65 6962-7500** 

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**DEREGISTRATION OF SECURITIES** 

This Post-Effective Amendment relates to the Registration Statement on Form S-8 (File No. 333-251052) (the "***Registration Statement***") of Opthea Limited ("***Registrant***"), filed with the Securities Exchange Commission (the "***SEC***") on December 1, 2020.

The Registrant is filing this Post-Effective Amendment to deregister any and all securities that remain unsold or otherwise unissued under the Registration Statement as of the date hereof. By filing this Post-Effective Amendment, the Registrant has terminated any and all offerings of its securities pursuant to the Registration Statement. Accordingly, the Registrant hereby terminates the effectiveness of the Registration Statement and, in accordance with the undertakings made by the Registrant in the Registration Statement to remove from registration by means of a post-effective amendment any securities that had been registered for issuance but remain unsold or otherwise unissued at the termination of the offering, the Registrant hereby removes and withdraws from registration any and all securities registered pursuant to the Registration Statement that remain unsold or otherwise unissued as of the date hereof.

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**SIGNATURES** 

Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Post-Effective Amendment No.1 to the Registration Statement on Form S-8 to be signed on its behalf by the undersigned, thereunto duly authorized, in New York, New York on November 10, 2025.

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| | |
|:---|:---|
| **OPTHEA LIMITED** | **OPTHEA LIMITED** |
| **By:** | */s/ Jeremy Levin, D.Phil, MB BChir* |
| **Name:** | Jeremy Levin, D.Phil, MB BChir |
| **Title:** | Chief Executive Officer |

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**SIGNATURE OF AUTHORIZED U.S. REPRESENTATIVE OF THE REGISTRANT** 

Pursuant to the requirements of the Securities Act of 1933, as amended, the undersigned, the duly authorized representative in the United States of Opthea Limited, has signed this Post-Effective Amendment No. 1 to the Registration Statement on Form S-8 on November 10, 2025.

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| | |
|:---|:---|
| **PUGLISI & ASSOCIATES** | **PUGLISI & ASSOCIATES** |
| By: | */s/ Donald J. Puglisi* |
|  | Name: Donald J. Puglisi |
|  | Title: Managing Director |

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