# EDGAR Filing Document

**Accession Number:** 0001329377
**File Stem:** 0001752724-25-205024
**Filing Date:** 2025-8
**Character Count:** 13921
**Document Hash:** a999f33aaa13c7491cf52a584ec352c4
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001752724-25-205024.hdr.sgml**: 20250826

**ACCESSION NUMBER**: 0001752724-25-205024

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20250630

**FILED AS OF DATE**: 20250826

**DATE AS OF CHANGE**: 20250826

**PERIOD START**: 20251231

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** FIRST TRUST EXCHANGE-TRADED FUND
- **CENTRAL INDEX KEY:** 0001329377

**ORGANIZATION NAME:**
- **EIN:** 000000000

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-21774
- **FILM NUMBER:** 251255556

**BUSINESS ADDRESS:**
- **STREET 1:** 120 EAST LIBERTY DRIVE, SUITE 400
- **CITY:** WHEATON
- **STATE:** IL
- **ZIP:** 60187
- **BUSINESS PHONE:** 630-765-8000

**MAIL ADDRESS:**
- **STREET 1:** 120 EAST LIBERTY DRIVE, SUITE 400
- **CITY:** WHEATON
- **STATE:** IL
- **ZIP:** 60187

## Series and Classes Contracts Data

### First Trust NYSE Arca Biotechnology Index Fund (Series ID: S000012478)

| Class ID   | Class Name                                     | Ticker Symbol   |
|:---|:---|:---|
| C000033929 | First Trust NYSE Arca Biotechnology Index Fund | FBT             |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** First Trust Exchange-Traded Fund

- **b. Investment Company Act file number:** 811-21774

- **c. CIK number of Registrant:** 0001329377

- **d. LEI of Registrant:** 549300MZB4XDLRWOC672

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 120 East Liberty Drive

  - **City:** Wheaton

  - **State:** IL

  - **Foreign country:** US

  - **Zip / Postal Code:** 60187

  - **Telephone number:** 630-765-8000

**Item A.2. Information about the Series.**

- **a. Name of Series:** First Trust NYSE Arca Biotechnology Index Fund

- **b. EDGAR series identifier (if any):** S000012478

- **c. LEI of Series:** 5493003ZQM0TVLDIBC50

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2025-12-31

- **b. Date as of which information is reported:** 2025-06-30

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $1006738687.77

**Total Liabilities:** $688945.31

**Net Assets:** $1006049742.46

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000033929 | -4.44%               | -0.92%               | -0.11%               |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $44779507.05             | $-94429060.05                              |
| Month 2  | $3337107.06              | $-13267225.27                              |
| Month 3  | $4211689.54              | $-4741556.23                               |

### Schedule of Portfolio Investments

| Name                               | Title                              | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Bruker Corp                        | Bruker Corp                        | CUSIP: 116794108<br>LEI: LEBZ6VLQ6I8XB1NHVY15 | Long             | EC               | CORP              | US        |    815286 | NS      | $33589783.20  | 3.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Amgen Inc                          | Amgen Inc                          | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |    110499 | NS      | $30852425.79  | 3.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Veracyte Inc                       | Veracyte Inc                       | CUSIP: 92337F107<br>LEI: 529900ESWZRHXOW27Z37 | Long             | EC               | CORP              | US        |    993724 | NS      | $26860359.72  | 2.67%             |  |  |  | No            |                  1 | On Loan: No      |
| Gilead Sciences Inc                | Gilead Sciences Inc                | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |    304936 | NS      | $33808254.32  | 3.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Genmab A/S                         | Genmab A/S                         | CUSIP: 372303206<br>LEI: 529900MTJPDPE4MHJ122 | Long             | EC               | CORP              | DK        |   1679981 | NS      | $34708407.46  | 3.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Dreyfus Government Cash Management | Dreyfus Government Cash Management | CUSIP: 262006208<br>LEI: 5493000Q69I5Q3QZIA91 | Long             | STIV             | RF                | US        |    920733 | NS      | $920732.57    | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Exact Sciences Corp                | Exact Sciences Corp                | CUSIP: 30063P105<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |    710922 | NS      | $37778395.08  | 3.76%             |  |  |  | No            |                  1 | On Loan: No      |
| Regeneron Pharmaceuticals Inc      | Regeneron Pharmaceuticals Inc      | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |     57022 | NS      | $29936550.00  | 2.98%             |  |  |  | No            |                  1 | On Loan: No      |
| Repligen Corp                      | Repligen Corp                      | CUSIP: 759916109<br>LEI: 54930006QJ0T5AUO1E71 | Long             | EC               | CORP              | US        |    257206 | NS      | $31991282.28  | 3.18%             |  |  |  | No            |                  1 | On Loan: No      |
| BioMarin Pharmaceutical Inc        | BioMarin Pharmaceutical Inc        | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |    556150 | NS      | $30571565.50  | 3.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals Inc        | Alnylam Pharmaceuticals Inc        | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |    132904 | NS      | $43338665.36  | 4.31%             |  |  |  | No            |                  1 | On Loan: No      |
| Natera Inc                         | Natera Inc                         | CUSIP: 632307104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    213458 | NS      | $36061594.52  | 3.58%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences Inc         | Neurocrine Biosciences Inc         | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |    347755 | NS      | $43709325.95  | 4.34%             |  |  |  | No            |                  1 | On Loan: No      |
| BioNTech SE                        | BioNTech SE                        | CUSIP: 09075V102<br>LEI: 894500UZJ5LG1F8J1U58 | Long             | EC               | CORP              | DE        |    327398 | NS      | $34858065.06  | 3.46%             |  |  |  | No            |                  1 | On Loan: No      |
| Halozyme Therapeutics Inc          | Halozyme Therapeutics Inc          | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |    524819 | NS      | $27301084.38  | 2.71%             |  |  |  | No            |                  1 | On Loan: No      |
| Mettler-Toledo International I     | Mettler-Toledo International Inc   | CUSIP: 592688105<br>LEI: 5493000BD5GJNUDIUG10 | Long             | EC               | CORP              | US        |     30329 | NS      | $35628082.88  | 3.54%             |  |  |  | No            |                  1 | On Loan: No      |
| Exelixis Inc                       | Exelixis Inc                       | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |    894942 | NS      | $39444568.65  | 3.92%             |  |  |  | No            |                  1 | On Loan: No      |
| Waters Corp                        | Waters Corp                        | CUSIP: 941848103<br>LEI: 5T547R1474YC9HOD8Q74 | Long             | EC               | CORP              | US        |     97167 | NS      | $33915169.68  | 3.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Corcept Therapeutics Inc           | Corcept Therapeutics Inc           | CUSIP: 218352102<br>LEI: 529900EO9LUTFMZ7FF90 | Long             | EC               | CORP              | US        |    460514 | NS      | $33801727.60  | 3.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals Inc         | Vertex Pharmaceuticals Inc         | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |     65261 | NS      | $29054197.20  | 2.89%             |  |  |  | No            |                  1 | On Loan: No      |
| United Therapeutics Corp           | United Therapeutics Corp           | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |    112393 | NS      | $32296128.55  | 3.21%             |  |  |  | No            |                  1 | On Loan: No      |
| ACADIA Pharmaceuticals Inc         | ACADIA Pharmaceuticals Inc         | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |   2167383 | NS      | $46750451.31  | 4.65%             |  |  |  | No            |                  1 | On Loan: No      |
| Incyte Corp                        | Incyte Corp                        | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |    555662 | NS      | $37840582.20  | 3.76%             |  |  |  | No            |                  1 | On Loan: No      |
| BeOne Medicines Ltd                | BeOne Medicines Ltd                | CUSIP: 07725L102<br>LEI: 549300JFUK6FRD5MH739 | Long             | EC               | CORP              | US        |    137179 | NS      | $33206920.53  | 3.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Sarepta Therapeutics Inc           | Sarepta Therapeutics Inc           | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |    619252 | NS      | $10589209.20  | 1.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Argenx SE                          | Argenx SE                          | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |     54396 | NS      | $29984163.12  | 2.98%             |  |  |  | No            |                  1 | On Loan: No      |
| BOFA SECURITIES, INC.              | BOFA SECURITIES INC                | CUSIP: 000000000<br>LEI: 549300HN4UKV1E2R3U73 | Long             | RA               | CORP              | US        |         4 | PA      | $4.00         | 0.00%             |  |  |  | No            |                  2 | On Loan: No      |
| Krystal Biotech Inc                | Krystal Biotech Inc                | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |    191518 | NS      | $26326064.28  | 2.62%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen Inc                         | Biogen Inc                         | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |    274381 | NS      | $34459509.79  | 3.43%             |  |  |  | No            |                  1 | On Loan: No      |
| Illumina Inc                       | Illumina Inc                       | CUSIP: 452327109<br>LEI: SQ95QG8SR5Q56LSNF682 | Long             | EC               | CORP              | US        |    422578 | NS      | $40318166.98  | 4.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Moderna Inc                        | Moderna Inc                        | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |   1206124 | NS      | $33276961.16  | 3.31%             |  |  |  | No            |                  1 | On Loan: No      |
| Alkermes PLC                       | Alkermes PLC                       | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | IE        |   1170387 | NS      | $33484772.07  | 3.33%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2025-08-25

**Name of Applicant:** First Trust Exchange-Traded Fund

**Signature:** Derek Maltbie

**Name of Signer:** Derek Maltbie

**Title:** Treasurer, Chief Financial Officer and Chief Accounting Officer