# EDGAR Filing Document

**Accession Number:** 0001064642
**File Stem:** 0001410368-26-020055
**Filing Date:** 2026-2
**Character Count:** 56395
**Document Hash:** 53a591a486ecbf63ae58b5b1c0e8aa8a
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001410368-26-020055.hdr.sgml**: 20260226

**ACCESSION NUMBER**: 0001410368-26-020055

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20251231

**FILED AS OF DATE**: 20260226

**DATE AS OF CHANGE**: 20260226

**PERIOD START**: 20260630

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** SPDR SERIES TRUST
- **CENTRAL INDEX KEY:** 0001064642

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** MA

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-08839
- **FILM NUMBER:** 26689889

**BUSINESS ADDRESS:**
- **STREET 1:** ONE CONGRESS STREET
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02114
- **BUSINESS PHONE:** 6176643920

**MAIL ADDRESS:**
- **STREET 1:** ONE CONGRESS STREET
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02114

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** STREETTRACKS SERIES TRUST
- **DATE OF NAME CHANGE:** 20000925

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** INDEX EXCHANGE LISTED SECURITIES TRUST
- **DATE OF NAME CHANGE:** 19980622

## Series and Classes Contracts Data

### State Street(R) SPDR(R) S&P(R) Biotech ETF (Series ID: S000010018)

| Class ID   | Class Name                                 | Ticker Symbol   |
|:---|:---|:---|
| C000027706 | State Street(R) SPDR(R) S&P(R) Biotech ETF | XBI             |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** SPDR SERIES TRUST

- **b. Investment Company Act file number:** 811-08839

- **c. CIK number of Registrant:** 0001064642

- **d. LEI of Registrant:** 5493004JVD6CQEEJSS37

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** One Congress Street

  - **City:** Boston

  - **State:** MA

  - **Foreign country:** US

  - **Zip / Postal Code:** 02114

  - **Telephone number:** 617-664-8594

**Item A.2. Information about the Series.**

- **a. Name of Series:** State Street(R) SPDR(R) S&P(R) Biotech ETF

- **b. EDGAR series identifier (if any):** S000010018

- **c. LEI of Series:** 549300Y3ODFMPD5XXL58

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2026-06-30

- **b. Date as of which information is reported:** 2025-12-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $8609599155.26

**Total Liabilities:** $760585735.25

**Net Assets:** $7849013420.01

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000027706 | 12.58%               | 9.18%                | -0.64%               |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $345815781.83            | $416451310.13                              |
| Month 2  | $415151612.79            | $239265850.94                              |
| Month 3  | $258632998.15            | $-326506027.11                             |

### Schedule of Portfolio Investments

| Name                           | Title                                                      | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| ADMA Biologics Inc             | ADMA Biologics Inc                                         | CUSIP: 000899104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   4850108 | NS      | $88465969.92  | 1.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Absci Corp                     | Absci Corp                                                 | CUSIP: 00091E109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   3393828 | NS      | $11844459.72  | 0.15%             |  |  |  | No            |                  1 | On Loan: —       |
| AbbVie Inc                     | AbbVie Inc                                                 | CUSIP: 00287Y109<br>LEI: FR5LCKFTG8054YNNRU85 | Long             | EC               | CORP              | US        |    430356 | NS      | $98332042.44  | 1.25%             |  |  |  | No            |                  1 | On Loan: No      |
| ACADIA Pharmaceuticals Inc     | ACADIA Pharmaceuticals Inc                                 | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |   3302738 | NS      | $88216131.98  | 1.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Invivyd Inc                    | Invivyd Inc                                                | CUSIP: 00534A102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   4715076 | NS      | $11646237.72  | 0.15%             |  |  |  | No            |                  1 | On Loan: —       |
| Spyre Therapeutics Inc         | Spyre Therapeutics Inc                                     | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |    884938 | NS      | $28990568.88  | 0.37%             |  |  |  | No            |                  1 | On Loan: —       |
| Agios Pharmaceuticals Inc      | Agios Pharmaceuticals Inc                                  | CUSIP: 00847X104<br>LEI: 529900ONJHY8EOGYT555 | Long             | EC               | CORP              | US        |   1781008 | NS      | $48479037.76  | 0.62%             |  |  |  | No            |                  1 | On Loan: —       |
| Akebia Therapeutics Inc        | Akebia Therapeutics Inc                                    | CUSIP: 00972D105<br>LEI: 549300CBQEHMKEEGNX42 | Long             | EC               | CORP              | US        |   8262059 | NS      | $13301914.99  | 0.17%             |  |  |  | No            |                  1 | On Loan: —       |
| CONTRA AKERO THERAPEUT         | CONTRA AKERO THERAPEUT                                     | CUSIP: 009CVR044<br>LEI: 549300SI3KG74LBE2955 | N/A              | DE               |  | US        |   2033975 | NS      | $1322083.75   | 0.02%             |  |  |  | No            |                  2 | On Loan: No      |
| State Street Global Advisors   | State Street Navigator Securities Lending Portfolio II     | CUSIP: 857492706<br>LEI: 5493008BJIBKQ5KTIF74 | Long             | STIV             | RF                | US        | 758192958 | NS      | $758192958.50 | 9.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals Inc    | Alnylam Pharmaceuticals Inc                                | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |    239615 | NS      | $95282904.75  | 1.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Altimmune Inc                  | Altimmune Inc                                              | CUSIP: 02155H200<br>LEI: 549300EOYCQ8SW3NVE64 | Long             | EC               | CORP              | US        |   3243800 | NS      | $11710118.00  | 0.15%             |  |  |  | No            |                  1 | On Loan: —       |
| Amgen Inc                      | Amgen Inc                                                  | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |    307313 | NS      | $100586618.03 | 1.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Amicus Therapeutics Inc        | Amicus Therapeutics Inc                                    | CUSIP: 03152W109<br>LEI: 549300MRD1SMUTNBPQ53 | Long             | EC               | CORP              | US        |   8213589 | NS      | $116961507.36 | 1.49%             |  |  |  | No            |                  1 | On Loan: No      |
| AnaptysBio Inc                 | AnaptysBio Inc                                             | CUSIP: 032724106<br>LEI: 529900HH4WQT03IG1A12 | Long             | EC               | CORP              | US        |    585056 | NS      | $28363514.88  | 0.36%             |  |  |  | No            |                  1 | On Loan: —       |
| Anavex Life Sciences Corp      | Anavex Life Sciences Corp                                  | CUSIP: 032797300<br>LEI: 549300K1I5L8COCQ8W36 | Long             | EC               | CORP              | US        |   2589739 | NS      | $9219470.84   | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Annexon Inc                    | Annexon Inc                                                | CUSIP: 03589W102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2347026 | NS      | $11782070.52  | 0.15%             |  |  |  | No            |                  1 | On Loan: —       |
| Apellis Pharmaceuticals Inc    | Apellis Pharmaceuticals Inc                                | CUSIP: 03753U106<br>LEI: 254900HS0ZFRXXSB9D42 | Long             | EC               | CORP              | US        |   2856301 | NS      | $71750281.12  | 0.91%             |  |  |  | No            |                  1 | On Loan: —       |
| Apogee Therapeutics Inc        | Apogee Therapeutics Inc                                    | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    805539 | NS      | $60802083.72  | 0.77%             |  |  |  | No            |                  1 | On Loan: —       |
| Arbutus Biopharma Corp         | Arbutus Biopharma Corp                                     | CUSIP: 03879J100<br>LEI: 25490064CESONAUIAS23 | Long             | EC               | CORP              | CA        |   1939237 | NS      | $9327729.97   | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Arcellx Inc                    | Arcellx Inc                                                | CUSIP: 03940C100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1158034 | NS      | $75503816.80  | 0.96%             |  |  |  | No            |                  1 | On Loan: —       |
| Ardelyx Inc                    | Ardelyx Inc                                                | CUSIP: 039697107<br>LEI: 549300F542QR4SXHCY32 | Long             | EC               | CORP              | US        |   6465673 | NS      | $37694873.59  | 0.48%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcus Biosciences Inc          | Arcus Biosciences Inc                                      | CUSIP: 03969F109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1539780 | NS      | $36692957.40  | 0.47%             |  |  |  | No            |                  1 | On Loan: —       |
| Arcutis Biotherapeutics Inc    | Arcutis Biotherapeutics Inc                                | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2866419 | NS      | $83240807.76  | 1.06%             |  |  |  | No            |                  1 | On Loan: No      |
| ArriVent Biopharma Inc         | ArriVent Biopharma Inc                                     | CUSIP: 04272N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    478439 | NS      | $9626192.68   | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Arrowhead Pharmaceuticals Inc  | Arrowhead Pharmaceuticals Inc                              | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |   1407073 | NS      | $93415576.47  | 1.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Avidity Biosciences Inc        | Avidity Biosciences Inc                                    | CUSIP: 05370A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1358205 | NS      | $97967326.65  | 1.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Bicara Therapeutics Inc        | Bicara Therapeutics Inc                                    | CUSIP: 055477103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    991186 | NS      | $16681660.38  | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Beam Therapeutics Inc          | Beam Therapeutics Inc                                      | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2946215 | NS      | $81669079.80  | 1.04%             |  |  |  | No            |                  1 | On Loan: —       |
| BioCryst Pharmaceuticals Inc   | BioCryst Pharmaceuticals Inc                               | CUSIP: 09058V103<br>LEI: 549300Z0INP1Z5NP6J59 | Long             | EC               | CORP              | US        |   6338749 | NS      | $49442242.20  | 0.63%             |  |  |  | No            |                  1 | On Loan: No      |
| BioMarin Pharmaceutical Inc    | BioMarin Pharmaceutical Inc                                | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |   1804534 | NS      | $107243455.62 | 1.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen Inc                     | Biogen Inc                                                 | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |    545762 | NS      | $96048654.38  | 1.22%             |  |  |  | No            |                  1 | On Loan: No      |
| CONTRA BLUEPRINT MEDIC         | CONTRA BLUEPRINT MEDIC                                     | CUSIP: 096CVR048<br>LEI: 5299004CC60O9T5HVM83 | N/A              | DE               |  | US        |    756469 | NS      | $347975.74    | 0.00%             |  |  |  | No            |                  2 | On Loan: No      |
| Bridgebio Pharma Inc           | Bridgebio Pharma Inc                                       | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |   1332926 | NS      | $101955509.74 | 1.30%             |  |  |  | No            |                  1 | On Loan: —       |
| CareDx Inc                     | CareDx Inc                                                 | CUSIP: 14167L103<br>LEI: 549300NQOFKL9NON0U06 | Long             | EC               | CORP              | US        |   1510042 | NS      | $28449191.28  | 0.36%             |  |  |  | No            |                  1 | On Loan: —       |
| Catalyst Pharmaceuticals Inc   | Catalyst Pharmaceuticals Inc                               | CUSIP: 14888U101<br>LEI: 5299004O0R5XXLA5H544 | Long             | EC               | CORP              | US        |   2568932 | NS      | $59958872.88  | 0.76%             |  |  |  | No            |                  1 | On Loan: No      |
| Celcuity Inc                   | Celcuity Inc                                               | CUSIP: 15102K100<br>LEI: 25490070W7UU7W2SEY87 | Long             | EC               | CORP              | US        |    951649 | NS      | $94917471.26  | 1.21%             |  |  |  | No            |                  1 | On Loan: —       |
| Celldex Therapeutics Inc       | Celldex Therapeutics Inc                                   | CUSIP: 15117B202<br>LEI: 529900F018DMYWH38923 | Long             | EC               | CORP              | US        |   1892703 | NS      | $51405813.48  | 0.65%             |  |  |  | No            |                  1 | On Loan: —       |
| CG oncology Inc                | CG oncology Inc                                            | CUSIP: 156944100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1757253 | NS      | $72961144.56  | 0.93%             |  |  |  | No            |                  1 | On Loan: —       |
| Cidara Therapeutics Inc        | Cidara Therapeutics Inc                                    | CUSIP: 171757206<br>LEI: 549300IHQ9Z7RI1X2D22 | Long             | EC               | CORP              | US        |    441318 | NS      | $97482733.02  | 1.24%             |  |  |  | No            |                  1 | On Loan: —       |
| Cogent Biosciences Inc         | Cogent Biosciences Inc                                     | CUSIP: 19240Q201<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1850655 | NS      | $65735265.60  | 0.84%             |  |  |  | No            |                  1 | On Loan: No      |
| Compass Therapeutics Inc       | Compass Therapeutics Inc                                   | CUSIP: 20454B104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2514338 | NS      | $13501995.06  | 0.17%             |  |  |  | No            |                  1 | On Loan: —       |
| Corvus Pharmaceuticals Inc     | Corvus Pharmaceuticals Inc                                 | CUSIP: 221015100<br>LEI: 549300I3AVJ8F75NCX65 | Long             | EC               | CORP              | US        |   1652375 | NS      | $12723287.50  | 0.16%             |  |  |  | No            |                  1 | On Loan: —       |
| Cullinan Therapeutics Inc      | Cullinan Therapeutics Inc                                  | CUSIP: 230031106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1021903 | NS      | $10576696.05  | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Cytokinetics Inc               | Cytokinetics Inc                                           | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |   1606699 | NS      | $102089654.46 | 1.30%             |  |  |  | No            |                  1 | On Loan: —       |
| CytomX Therapeutics Inc        | CytomX Therapeutics Inc                                    | CUSIP: 23284F105<br>LEI: 5493004VW2FW0QLL3345 | Long             | EC               | CORP              | US        |   4533138 | NS      | $19311167.88  | 0.25%             |  |  |  | No            |                  1 | On Loan: —       |
| Day One Biopharmaceuticals Inc | Day One Biopharmaceuticals Inc                             | CUSIP: 23954D109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2601616 | NS      | $24247061.12  | 0.31%             |  |  |  | No            |                  1 | On Loan: —       |
| Denali Therapeutics Inc        | Denali Therapeutics Inc                                    | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |   3174147 | NS      | $52405166.97  | 0.67%             |  |  |  | No            |                  1 | On Loan: —       |
| Dianthus Therapeutics Inc      | Dianthus Therapeutics Inc                                  | CUSIP: 252828108<br>LEI: 549300Z3N6ODPCOFC890 | Long             | EC               | CORP              | US        |    958871 | NS      | $39515073.91  | 0.50%             |  |  |  | No            |                  1 | On Loan: —       |
| Disc Medicine Inc              | Disc Medicine Inc                                          | CUSIP: 254604101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    598028 | NS      | $47489403.48  | 0.61%             |  |  |  | No            |                  1 | On Loan: No      |
| Dynavax Technologies Corp      | Dynavax Technologies Corp                                  | CUSIP: 268158201<br>LEI: 549300T5URIXWDILX594 | Long             | EC               | CORP              | US        |   3047443 | NS      | $46869673.34  | 0.60%             |  |  |  | No            |                  1 | On Loan: —       |
| Dyne Therapeutics Inc          | Dyne Therapeutics Inc                                      | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   3895365 | NS      | $76193339.40  | 0.97%             |  |  |  | No            |                  1 | On Loan: —       |
| Emergent BioSolutions Inc      | Emergent BioSolutions Inc                                  | CUSIP: 29089Q105<br>LEI: 549300YW6TUOX8BE5103 | Long             | EC               | CORP              | US        |   1474999 | NS      | $18230987.64  | 0.23%             |  |  |  | No            |                  1 | On Loan: —       |
| Erasca Inc                     | Erasca Inc                                                 | CUSIP: 29479A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2170944 | NS      | $8075911.68   | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| Exact Sciences Corp            | Exact Sciences Corp                                        | CUSIP: 30063P105<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |    957047 | NS      | $97197693.32  | 1.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Exelixis Inc                   | Exelixis Inc                                               | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |   2359522 | NS      | $103417849.26 | 1.32%             |  |  |  | No            |                  1 | On Loan: No      |
| 4D Molecular Therapeutics Inc  | 4D Molecular Therapeutics Inc                              | CUSIP: 35104E100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1382120 | NS      | $10365900.00  | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Geron Corp                     | Geron Corp                                                 | CUSIP: 374163103<br>LEI: 549300T282D7Z2YESL90 | Long             | EC               | CORP              | US        |  13618323 | NS      | $17976186.36  | 0.23%             |  |  |  | No            |                  1 | On Loan: —       |
| Gilead Sciences Inc            | Gilead Sciences Inc                                        | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |    798703 | NS      | $98032806.22  | 1.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Gossamer Bio Inc               | Gossamer Bio Inc                                           | CUSIP: 38341P102<br>LEI: 549300ZOC0N2W6PSFR58 | Long             | EC               | CORP              | US        |   5182950 | NS      | $16067145.00  | 0.20%             |  |  |  | No            |                  1 | On Loan: —       |
| GRAIL Inc                      | GRAIL Inc                                                  | CUSIP: 384747101<br>LEI: 2549009XSNESW3VE8024 | Long             | EC               | CORP              | US        |   1020826 | NS      | $87372497.34  | 1.11%             |  |  |  | No            |                  1 | On Loan: —       |
| Halozyme Therapeutics Inc      | Halozyme Therapeutics Inc                                  | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |   1546804 | NS      | $104099909.20 | 1.33%             |  |  |  | No            |                  1 | On Loan: —       |
| Ideaya Biosciences Inc         | Ideaya Biosciences Inc                                     | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |   2105030 | NS      | $72770887.10  | 0.93%             |  |  |  | No            |                  1 | On Loan: —       |
| Immuneering Corp               | Immuneering Corp                                           | CUSIP: 45254E107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2166388 | NS      | $14254833.04  | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| ImmunityBio Inc                | ImmunityBio Inc                                            | CUSIP: 45256X103<br>LEI: 529900J9XLBR4HFL4B83 | Long             | EC               | CORP              | US        |  10063186 | NS      | $19925108.28  | 0.25%             |  |  |  | No            |                  1 | On Loan: —       |
| Immunome Inc                   | Immunome Inc                                               | CUSIP: 45257U108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1878860 | NS      | $40357912.80  | 0.51%             |  |  |  | No            |                  1 | On Loan: —       |
| Immunovant Inc                 | Immunovant Inc                                             | CUSIP: 45258J102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2192830 | NS      | $55741738.60  | 0.71%             |  |  |  | No            |                  1 | On Loan: —       |
| Incyte Corp                    | Incyte Corp                                                | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |   1018249 | NS      | $100572453.73 | 1.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Inhibrx Biosciences Inc        | Inhibrx Biosciences Inc                                    | CUSIP: 45720N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    142168 | NS      | $11231272.00  | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| Insmed Inc                     | Insmed Inc                                                 | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |    510448 | NS      | $88838369.92  | 1.13%             |  |  |  | No            |                  1 | On Loan: No      |
| CONTRA INHIBRX INC             | CONTRA INHIBRX INC                                         | CUSIP: 457CVR017<br>LEI: 549300VBKG2LTV1TLY22 | N/A              | DE               |  | US        |   1645973 | NS      | $1069882.45   | 0.01%             |  |  |  | No            |                  2 | On Loan: —       |
| Intellia Therapeutics Inc      | Intellia Therapeutics Inc                                  | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |   3569495 | NS      | $32089760.05  | 0.41%             |  |  |  | No            |                  1 | On Loan: —       |
| Ionis Pharmaceuticals Inc      | Ionis Pharmaceuticals Inc                                  | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |   1232380 | NS      | $97493581.80  | 1.24%             |  |  |  | No            |                  1 | On Loan: —       |
| Iovance Biotherapeutics Inc    | Iovance Biotherapeutics Inc                                | CUSIP: 462260100<br>LEI: 2549002L8WT2ACU5Q878 | Long             | EC               | CORP              | US        |  11705488 | NS      | $31955982.24  | 0.41%             |  |  |  | No            |                  1 | On Loan: —       |
| Ironwood Pharmaceuticals Inc   | Ironwood Pharmaceuticals Inc                               | CUSIP: 46333X108<br>LEI: 549300PC8MR6QHH6P296 | Long             | EC               | CORP              | US        |   1074360 | NS      | $3620593.20   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Janux Therapeutics Inc         | Janux Therapeutics Inc                                     | CUSIP: 47103J105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2903728 | NS      | $40071446.40  | 0.51%             |  |  |  | No            |                  1 | On Loan: —       |
| KalVista Pharmaceuticals Inc   | KalVista Pharmaceuticals Inc                               | CUSIP: 483497103<br>LEI: 529900Q7IDA3WUGRZA51 | Long             | EC               | CORP              | US        |   1086810 | NS      | $17551981.50  | 0.22%             |  |  |  | No            |                  1 | On Loan: —       |
| Keros Therapeutics Inc         | Keros Therapeutics Inc                                     | CUSIP: 492327101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    501687 | NS      | $10214347.32  | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Kodiak Sciences Inc            | Kodiak Sciences Inc                                        | CUSIP: 50015M109<br>LEI: 254900IXI5NI8C9OQE24 | Long             | EC               | CORP              | US        |    986230 | NS      | $27574990.80  | 0.35%             |  |  |  | No            |                  1 | On Loan: —       |
| Krystal Biotech Inc            | Krystal Biotech Inc                                        | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |    404233 | NS      | $99659603.82  | 1.27%             |  |  |  | No            |                  1 | On Loan: —       |
| Kura Oncology Inc              | Kura Oncology Inc                                          | CUSIP: 50127T109<br>LEI: 5493005QORQTZCZYOP39 | Long             | EC               | CORP              | US        |   3104937 | NS      | $32260295.43  | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Kymera Therapeutics Inc        | Kymera Therapeutics Inc                                    | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    977053 | NS      | $76024493.93  | 0.97%             |  |  |  | No            |                  1 | On Loan: —       |
| Lexeo Therapeutics Inc         | Lexeo Therapeutics Inc                                     | CUSIP: 52886X107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1692758 | NS      | $16809086.94  | 0.21%             |  |  |  | No            |                  1 | On Loan: —       |
| Madrigal Pharmaceuticals Inc   | Madrigal Pharmaceuticals Inc                               | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |    175411 | NS      | $102148841.74 | 1.30%             |  |  |  | No            |                  1 | On Loan: —       |
| MannKind Corp                  | MannKind Corp                                              | CUSIP: 56400P706<br>LEI: 213800GFBCNY1ZFST722 | Long             | EC               | CORP              | US        |   7497212 | NS      | $42509192.04  | 0.54%             |  |  |  | No            |                  1 | On Loan: No      |
| CONTRA METSERA INC             | CONTRA METSERA INC                                         | CUSIP: 592CVR013<br>LEI: N/A                  | N/A              | DE               |  | US        |   1530714 | NS      | $7500498.60   | 0.10%             |  |  |  | No            |                  2 | On Loan: No      |
| MiMedx Group Inc               | MiMedx Group Inc                                           | CUSIP: 602496101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1148277 | NS      | $7773835.29   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Mineralys Therapeutics Inc     | Mineralys Therapeutics Inc                                 | CUSIP: 603170101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2130912 | NS      | $77330796.48  | 0.99%             |  |  |  | No            |                  1 | On Loan: —       |
| Mirum Pharmaceuticals Inc      | Mirum Pharmaceuticals Inc                                  | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |   1215159 | NS      | $95985409.41  | 1.22%             |  |  |  | No            |                  1 | On Loan: —       |
| CONTRA MIRATI THERAPEU         | CONTRA MIRATI THERAPEU                                     | CUSIP: 604CVR027<br>LEI: 529900GYRW59IDQV6N54 | N/A              | DE               |  | US        |   1369552 | NS      | $958686.40    | 0.01%             |  |  |  | No            |                  2 | On Loan: —       |
| Moderna Inc                    | Moderna Inc                                                | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |   3338095 | NS      | $98440421.55  | 1.25%             |  |  |  | No            |                  1 | On Loan: —       |
| Monte Rosa Therapeutics Inc    | Monte Rosa Therapeutics Inc                                | CUSIP: 61225M102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1117486 | NS      | $17522180.48  | 0.22%             |  |  |  | No            |                  1 | On Loan: —       |
| Myriad Genetics Inc            | Myriad Genetics Inc                                        | CUSIP: 62855J104<br>LEI: 52990044IHUOUMETT163 | Long             | EC               | CORP              | US        |   2472629 | NS      | $15206668.35  | 0.19%             |  |  |  | No            |                  1 | On Loan: —       |
| Natera Inc                     | Natera Inc                                                 | CUSIP: 632307104<br>LEI: 529900CQ3OZ0A0VYVU59 | Long             | EC               | CORP              | US        |    415680 | NS      | $95228131.20  | 1.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences Inc     | Neurocrine Biosciences Inc                                 | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |    622683 | NS      | $88315129.89  | 1.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Novavax Inc                    | Novavax Inc                                                | CUSIP: 670002401<br>LEI: 529900J4GJHPEPQ23205 | Long             | EC               | CORP              | US        |   5459421 | NS      | $36687309.12  | 0.47%             |  |  |  | No            |                  1 | On Loan: —       |
| Nuvalent Inc                   | Nuvalent Inc                                               | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    765391 | NS      | $76990680.69  | 0.98%             |  |  |  | No            |                  1 | On Loan: —       |
| Nurix Therapeutics Inc         | Nurix Therapeutics Inc                                     | CUSIP: 67080M103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1499744 | NS      | $28450143.68  | 0.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Olema Pharmaceuticals Inc      | Olema Pharmaceuticals Inc                                  | CUSIP: 68062P106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    745798 | NS      | $18644950.00  | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| OMNIAB INC                     | OMNIAB INC                                                 | CUSIP: 68218J202<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    161959 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  3 | On Loan: —       |
| OMNIAB INC                     | OMNIAB INC                                                 | CUSIP: 68218J301<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    161959 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  3 | On Loan: —       |
| ORIC Pharmaceuticals Inc       | ORIC Pharmaceuticals Inc                                   | CUSIP: 68622P109<br>LEI: 54930033FJRNEYBW0L25 | Long             | EC               | CORP              | US        |   2935786 | NS      | $24014729.48  | 0.31%             |  |  |  | No            |                  1 | On Loan: —       |
| Oruka Therapeutics Inc         | Oruka Therapeutics Inc                                     | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |    637656 | NS      | $19327353.36  | 0.25%             |  |  |  | No            |                  1 | On Loan: —       |
| PTC Therapeutics Inc           | PTC Therapeutics Inc                                       | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |   1307796 | NS      | $99340184.16  | 1.27%             |  |  |  | No            |                  1 | On Loan: No      |
| Palvella Therapeutics Inc      | Palvella Therapeutics Inc                                  | CUSIP: 697947109<br>LEI: 254900AJDH8PAOOI5T33 | Long             | EC               | CORP              | US        |    260656 | NS      | $27282863.52  | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Praxis Precision Medicines Inc | Praxis Precision Medicines Inc                             | CUSIP: 74006W207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    370413 | NS      | $109175527.62 | 1.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Precigen Inc                   | Precigen Inc                                               | CUSIP: 74017N105<br>LEI: 549300XCWNQU35K64G19 | Long             | EC               | CORP              | US        |   6200299 | NS      | $25917249.82  | 0.33%             |  |  |  | No            |                  1 | On Loan: —       |
| Prime Medicine Inc             | Prime Medicine Inc                                         | CUSIP: 74168J101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   3110270 | NS      | $10792636.90  | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| Protagonist Therapeutics Inc   | Protagonist Therapeutics Inc                               | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1060446 | NS      | $92619353.64  | 1.18%             |  |  |  | No            |                  1 | On Loan: —       |
| RAPT Therapeutics Inc          | RAPT Therapeutics Inc                                      | CUSIP: 75382E208<br>LEI: 549300MB473BIU78ES48 | Long             | EC               | CORP              | US        |    546579 | NS      | $18512630.73  | 0.24%             |  |  |  | No            |                  1 | On Loan: —       |
| Recursion Pharmaceuticals Inc  | Recursion Pharmaceuticals Inc                              | CUSIP: 75629V104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |  16052808 | NS      | $65655984.72  | 0.84%             |  |  |  | No            |                  1 | On Loan: —       |
| Regeneron Pharmaceuticals Inc  | Regeneron Pharmaceuticals Inc                              | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |    133448 | NS      | $103004507.76 | 1.31%             |  |  |  | No            |                  1 | On Loan: No      |
| REGENXBIO Inc                  | REGENXBIO Inc                                              | CUSIP: 75901B107<br>LEI: 549300EOES47LATSET33 | Long             | EC               | CORP              | US        |    980913 | NS      | $14125147.20  | 0.18%             |  |  |  | No            |                  1 | On Loan: —       |
| Relay Therapeutics Inc         | Relay Therapeutics Inc                                     | CUSIP: 75943R102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   3210433 | NS      | $27160263.18  | 0.35%             |  |  |  | No            |                  1 | On Loan: —       |
| Replimune Group Inc            | Replimune Group Inc                                        | CUSIP: 76029N106<br>LEI: 549300AY704NEIRC4K64 | Long             | EC               | CORP              | US        |   2334806 | NS      | $22694314.32  | 0.29%             |  |  |  | No            |                  1 | On Loan: —       |
| Revolution Medicines Inc       | Revolution Medicines Inc                                   | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |   1244382 | NS      | $99115026.30  | 1.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Rezolute Inc                   | Rezolute Inc                                               | CUSIP: 76200L309<br>LEI: 549300T05L48T72P2G08 | Long             | EC               | CORP              | US        |   2309757 | NS      | $5451026.52   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Rhythm Pharmaceuticals Inc     | Rhythm Pharmaceuticals Inc                                 | CUSIP: 76243J105<br>LEI: 529900JPNWXQ8DPLA551 | Long             | EC               | CORP              | US        |    925008 | NS      | $99012856.32  | 1.26%             |  |  |  | No            |                  1 | On Loan: —       |
| Rigel Pharmaceuticals Inc      | Rigel Pharmaceuticals Inc                                  | CUSIP: 766559702<br>LEI: 529900KPTNUS5J8K9K66 | Long             | EC               | CORP              | US        |    714077 | NS      | $30583917.91  | 0.39%             |  |  |  | No            |                  1 | On Loan: —       |
| Sana Biotechnology Inc         | Sana Biotechnology Inc                                     | CUSIP: 799566104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   4542631 | NS      | $18488508.17  | 0.24%             |  |  |  | No            |                  1 | On Loan: —       |
| Sarepta Therapeutics Inc       | Sarepta Therapeutics Inc                                   | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |   3235338 | NS      | $69624473.76  | 0.89%             |  |  |  | No            |                  1 | On Loan: —       |
| Savara Inc                     | Savara Inc                                                 | CUSIP: 805111101<br>LEI: 5493002JO0WM3YMJXG33 | Long             | EC               | CORP              | US        |   1488896 | NS      | $8978042.88   | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| Scholar Rock Holding Corp      | Scholar Rock Holding Corp                                  | CUSIP: 80706P103<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |   2151056 | NS      | $94754016.80  | 1.21%             |  |  |  | No            |                  1 | On Loan: —       |
| ARS Pharmaceuticals Inc        | ARS Pharmaceuticals Inc                                    | CUSIP: 82835W108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1914798 | NS      | $22307396.70  | 0.28%             |  |  |  | No            |                  1 | On Loan: —       |
| Sionna Therapeutics Inc        | Sionna Therapeutics Inc                                    | CUSIP: 829401108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    409080 | NS      | $16829551.20  | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Soleno Therapeutics Inc        | Soleno Therapeutics Inc                                    | CUSIP: 834203309<br>LEI: 5493003LCY77N7FXK844 | Long             | EC               | CORP              | US        |   1592549 | NS      | $73735018.70  | 0.94%             |  |  |  | No            |                  1 | On Loan: —       |
| Stoke Therapeutics Inc         | Stoke Therapeutics Inc                                     | CUSIP: 86150R107<br>LEI: 549300RD25SS2DIJHJ67 | Long             | EC               | CORP              | US        |   1494391 | NS      | $47431970.34  | 0.60%             |  |  |  | No            |                  1 | On Loan: —       |
| Summit Therapeutics Inc        | Summit Therapeutics Inc                                    | CUSIP: 86627T108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   4794427 | NS      | $83854528.23  | 1.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Syndax Pharmaceuticals Inc     | Syndax Pharmaceuticals Inc                                 | CUSIP: 87164F105<br>LEI: 529900OF94TRHKZVBS87 | Long             | EC               | CORP              | US        |   2683412 | NS      | $56378486.12  | 0.72%             |  |  |  | No            |                  1 | On Loan: —       |
| Tango Therapeutics Inc         | Tango Therapeutics Inc                                     | CUSIP: 87583X109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   3754627 | NS      | $33265995.22  | 0.42%             |  |  |  | No            |                  1 | On Loan: —       |
| Taysha Gene Therapies Inc      | Taysha Gene Therapies Inc                                  | CUSIP: 877619106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   5712858 | NS      | $31420719.00  | 0.40%             |  |  |  | No            |                  1 | On Loan: —       |
| TG Therapeutics Inc            | TG Therapeutics Inc                                        | CUSIP: 88322Q108<br>LEI: 529900X21UKABN9NJ529 | Long             | EC               | CORP              | US        |   3166842 | NS      | $94403560.02  | 1.20%             |  |  |  | No            |                  1 | On Loan: —       |
| Travere Therapeutics Inc       | Travere Therapeutics Inc                                   | CUSIP: 89422G107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2818736 | NS      | $107703902.56 | 1.37%             |  |  |  | No            |                  1 | On Loan: —       |
| Twist Bioscience Corp          | Twist Bioscience Corp                                      | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |   1893174 | NS      | $60051479.28  | 0.77%             |  |  |  | No            |                  1 | On Loan: —       |
| Tyra Biosciences Inc           | Tyra Biosciences Inc                                       | CUSIP: 90240B106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    256100 | NS      | $6732869.00   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Ultragenyx Pharmaceutical Inc  | Ultragenyx Pharmaceutical Inc                              | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |   2616367 | NS      | $60176441.00  | 0.77%             |  |  |  | No            |                  1 | On Loan: No      |
| United Therapeutics Corp       | United Therapeutics Corp                                   | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |    199853 | NS      | $97378374.25  | 1.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Upstream Bio Inc               | Upstream Bio Inc                                           | CUSIP: 91678A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    641069 | NS      | $17405023.35  | 0.22%             |  |  |  | No            |                  1 | On Loan: —       |
| Vaxcyte Inc                    | Vaxcyte Inc                                                | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |   2228160 | NS      | $102807302.40 | 1.31%             |  |  |  | No            |                  1 | On Loan: No      |
| Verastem Inc                   | Verastem Inc                                               | CUSIP: 92337C203<br>LEI: 549300IY0EFBIU8NQC81 | Long             | EC               | CORP              | US        |   2143034 | NS      | $16544222.48  | 0.21%             |  |  |  | No            |                  1 | On Loan: —       |
| Veracyte Inc                   | Veracyte Inc                                               | CUSIP: 92337F107<br>LEI: 529900ESWZRHXOW27Z37 | Long             | EC               | CORP              | US        |   1430968 | NS      | $60243752.80  | 0.77%             |  |  |  | No            |                  1 | On Loan: —       |
| Vera Therapeutics Inc          | Vera Therapeutics Inc                                      | CUSIP: 92337R101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1429875 | NS      | $72408870.00  | 0.92%             |  |  |  | No            |                  1 | On Loan: —       |
| Vericel Corp                   | Vericel Corp                                               | CUSIP: 92346J108<br>LEI: 54930076YM3PLTDR4B91 | Long             | EC               | CORP              | US        |   1252699 | NS      | $45109690.99  | 0.57%             |  |  |  | No            |                  1 | On Loan: —       |
| State Street Global Advisors   | State Street Institutional US Government Money Market Fund | CUSIP: 857492706<br>LEI: 549300BZ5TGIFZUZDZ37 | Long             | STIV             | RF                | US        |   4591437 | NS      | $4591436.96   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals Inc     | Vertex Pharmaceuticals Inc                                 | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |    217908 | NS      | $98790770.88  | 1.26%             |  |  |  | No            |                  1 | On Loan: No      |
| CONTRA VERVE THERAPEUT         | CONTRA VERVE THERAPEUT                                     | CUSIP: 925CVR011<br>LEI: N/A                  | N/A              | DE               |  | US        |    900273 | NS      | $567171.99    | 0.01%             |  |  |  | No            |                  2 | On Loan: No      |
| Viking Therapeutics Inc        | Viking Therapeutics Inc                                    | CUSIP: 92686J106<br>LEI: 529900IVC72YPFA25M37 | Long             | EC               | CORP              | US        |   2582129 | NS      | $90839298.22  | 1.16%             |  |  |  | No            |                  1 | On Loan: —       |
| Vir Biotechnology Inc          | Vir Biotechnology Inc                                      | CUSIP: 92764N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2216403 | NS      | $13364910.09  | 0.17%             |  |  |  | No            |                  1 | On Loan: —       |
| Viridian Therapeutics Inc      | Viridian Therapeutics Inc                                  | CUSIP: 92790C104<br>LEI: 549300C775BNYF550E70 | Long             | EC               | CORP              | US        |   1652815 | NS      | $51435602.80  | 0.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Xencor Inc                     | Xencor Inc                                                 | CUSIP: 98401F105<br>LEI: 549300V5IF65437JKG30 | Long             | EC               | CORP              | US        |   1619613 | NS      | $24796275.03  | 0.32%             |  |  |  | No            |                  1 | On Loan: —       |
| Alkermes PLC                   | Alkermes PLC                                               | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | IE        |   3385951 | NS      | $94738908.98  | 1.21%             |  |  |  | No            |                  1 | On Loan: —       |
| Biohaven Ltd                   | Biohaven Ltd                                               | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | VG        |   3468070 | NS      | $39154510.30  | 0.50%             |  |  |  | No            |                  1 | On Loan: —       |
| Prothena Corp PLC              | Prothena Corp PLC                                          | CUSIP: 000000000<br>LEI: 5299009ZXQ8NIIJ8OL30 | Long             | EC               | CORP              | IE        |   1367952 | NS      | $13063941.60  | 0.17%             |  |  |  | No            |                  1 | On Loan: —       |
| Roivant Sciences Ltd           | Roivant Sciences Ltd                                       | CUSIP: 000000000<br>LEI: 549300DL466NY5J6U724 | Long             | EC               | CORP              | BM        |   4787868 | NS      | $103896735.60 | 1.32%             |  |  |  | No            |                  1 | On Loan: No      |
| CRISPR Therapeutics AG         | CRISPR Therapeutics AG                                     | CUSIP: 000000000<br>LEI: 506700O6IRRIQLT3W370 | Long             | EC               | CORP              | CH        |   1682680 | NS      | $88239739.20  | 1.12%             |  |  |  | No            |                  1 | On Loan: —       |
| uniQure NV                     | uniQure NV                                                 | CUSIP: 000000000<br>LEI: 724500RPCTZLFYJZ3S98 | Long             | EC               | CORP              | NL        |   2732955 | NS      | $65399613.15  | 0.83%             |  |  |  | No            |                  1 | On Loan: —       |

### Signature

**Date Signed:** 2026-01-16

**Name of Applicant:** SPDR SERIES TRUST

**Signature:** Arthur Jensen

**Name of Signer:** Arthur Jensen

**Title:** Deputy Treasurer