# EDGAR Filing Document

**Accession Number:** 0001191070
**File Stem:** 0000950170-23-003898
**Filing Date:** 2023-2
**Character Count:** 68256
**Document Hash:** c5c4aa7f3adf42a9752be8887be054f9
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000950170-23-003898.hdr.sgml**: 20230223

**ACCESSION NUMBER**: 0000950170-23-003898

**CONFORMED SUBMISSION TYPE**: 6-K

**PUBLIC DOCUMENT COUNT**: 13

**CONFORMED PERIOD OF REPORT**: 20230223

**FILED AS OF DATE**: 20230223

**DATE AS OF CHANGE**: 20230223

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** BIONOMICS LIMITED/FI
- **CENTRAL INDEX KEY:** 0001191070
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** C3

**FILING VALUES:**
- **FORM TYPE:** 6-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-41157
- **FILM NUMBER:** 23655770

**BUSINESS ADDRESS:**
- **STREET 1:** 200 GREENHILL ROAD
- **CITY:** EASTWOOD SA
- **STATE:** C3
- **ZIP:** 5063
- **BUSINESS PHONE:** 61 8 8150 7400

**MAIL ADDRESS:**
- **STREET 1:** 200 GREENHILL ROAD
- **CITY:** EASTWOOD SA
- **STATE:** C3
- **ZIP:** 5063

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**Washington, D.C. 20549** 

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**FORM 6-K** 

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**REPORT OF FOREIGN ISSUER** 

**PURSUANT TO RULE 13a-16 OR 15d-16** 

**OF THE SECURITIES EXCHANGE ACT OF 1934** 

**For the month of February, 2023** 

**(Commission File No. 001-41157)** 

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**BIONOMICS LIMITED**

**(Translation of registrant's name into English)** 

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**200 Greenhill Road**

**Eastwood SA 5063**

**Tel: +618 8150 7400]**

**(Address of registrant's principal executive office)** 

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Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.

Form 20-F ☒ Form 40-F ☐

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101 (b) (1):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Yes ☐ No ☐

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101 (b) (7):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Yes ☐ No ☐

Indicate by check mark whether the registrant by furnishing the information contained in this Form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Yes ☐ No ☐

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**INFORMATION CONTAINED IN THIS REPORT ON FORM 6-K**

On February 23, 2023 Bionomics Limited (the "Company") lodged with the Australian Securities Exchange (ASX), as required by the laws and regulations of Australia, "Bionomics Limited half-year information - December 31, 2022", including the half-year report of the Company. The Announcement is furnished herewith as Exhibit 99.1 to this report on Form 6-K.

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**EXHIBIT INDEX** 

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| | |
|:---|:---|
| **Exhibit**<br>| &nbsp;&nbsp;&nbsp;**Description**<br>|
| &nbsp;&nbsp;99.1 | &nbsp;&nbsp;[<u>ASX Half-Year Information - December 31, 2022</u>](bnox-ex99_1.htm) |

---

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**<u>SIGNATURES</u>** 

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereto duly authorized.

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| | |
|:---|:---|
| **Bionomics Limited** | **Bionomics Limited** |
| (Registrant) | (Registrant) |
| By: | /s/ Errol De Souza<br>|
| Name: | Errol De Souza, Ph.D. |
| Title: | Chairman of the Board |

---

Date: February 23, 2023

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## Ex-99

**Exhibit 99.1**

![img65882896_0.jpg](img65882896_0.jpg)

ABN 53 075 582 740

**BIONOMICS LIMITED**

ASX half-year information –

31 December 2022

Lodged with the ASX under Listing Rule 4.2A

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| | |
|:---|:---|
| **Contents** | **Page** |
| <br>[**<u>Results for Announcement to the Market</u>**](#results_for_announcement_to_the_market) | 2 |
| <br>[**<u>Announcement</u>**](#announcement) | <br>3 |
| <br>[**<u>Half-year Report</u>**](#half_year_report) | <br>5 |

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Page 1 of 26

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**BIONOMICS LIMITED**

Half-year ended 31 December 2022

(Previous corresponding period: Half-year ended 31 December 2021)

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**Results for announcement to the market**

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| | | | | |
|:---|:---|:---|:---|:---|
|  |  |  |  | **<u>$</u>** |
| Cash and cash equivalents at 31 December 2022 from 30 June 2022 | decreased by | $2,866,495 (8.5%) | to | 30698362 |
| Net operating cash outflows for the period | decreased by | $3,830,223 (29.8%) | to | 9008936 |
| Net investing cash inflows for the period | decreased by | $423,215 (68.9%) | to | 191100 |
| Net financing cash inflows for the period | decreased by | $18,620,454 (75.8%) | to | 5954412 |
| Loss for the half-year before income tax from continuing operations | increased by | $3,163,329 (24.1%) | to | 16311890 |
| Loss for the half-year after tax  | increased by | $3,154,226 (24.2%) | to | 16207967 |

---

**Explanation of cash and cash equivalents position as of 31 December 2022**

Closing cash and cash equivalents are in line with expectations, with net funds raised through share issues used to continue to progress the BNC210 development and pay the operating expenditure.

**Explanation of operating outflows**

Net cash outflows from operating activities decreased during the period due to receiving research and development incentives for the years ended 30 June 2021, and 2022, during the half-year that ended 31 December 2022, as the Company lodged the claim for the year ended 30 June 2021, during June 2022 and the claim for the year ended 30 June 2022, during September 2022, offset by an increase in payments to suppliers and employees, due to increased activities.

**Explanation of net investment inflows**

Net cash inflows from investing activities decreased during the period due to a decrease in proceeds from other financial assets (term deposits) and the sale of plant and equipment offset by an increase in interest received.

**Explanation of net financing inflows**

Net cash inflows from financing activities decreased during the period as a result of a decrease in net proceeds from share issues received offset by a decrease in principal element of lease repayments.

**Explanation of net loss from ordinary activities after tax**

The increase in half-year loss principally reflects an increase in research and development expenses, and compliance expenses, offset by an increase in realised and unrealised foreign exchange gain and a decrease in administrative expenses.

**Dividends/distributions**

Bionomics Limited does not propose to pay any dividends for the half-year ended 31 December 2022.

**NTA Backing**

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| | | |
|:---|:---|:---|
|  | **Half-year** | **Half-year** |
|  | **31 December 2022** | &nbsp;&nbsp;**31 December 2021** |
| Net tangible asset backing per ordinary share | 2.02 cents | &nbsp;&nbsp;2.90 cents |

---

Page 2 of 26

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![img65882896_1.jpg](img65882896_1.jpg)

ABN 53 075 582 740

**ASX ANNOUNCEMENT**

**23 February 2023**

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**BIONOMICS' HALF-YEAR REPORT**

Adelaide, Australia: Bionomics Limited (ASX: BNO, NASDAQ: BNOX), today announced its FY2023 report for the half-year ended 31 December 2022. This period represented a transformational time for Bionomics in which the Company made great strides on multiple fronts, including progress on advancing the pipeline, raising capital, and implementing strategic corporate initiatives designed to create long-term shareholder value.

The Company recently completed its Phase 2 PREVAIL Study to evaluate BNC210 for the acute treatment of Social Anxiety Disorder (SAD). The PREVAIL Study, initiated in January 2022, was a randomised, double-blind, placebo-controlled, multi-center Phase 2 clinical trial with a single dose treatment conducted at 15 sites in the US and recruited approximately 150 patients with SAD. The PREVAIL Study completed recruitment, and topline data were reported on 19 December 2022. The Company announced that while the primary endpoint, as measured by the change from baseline to the average of the Subjective Units of Distress Scale (SUDS) scores during a 5-minute Public Speaking Challenge was not met in the BNC210-treated patients when compared to placebo, the findings did indicate a consistent trend toward improvements across primary and secondary endpoints and a favourable safety and tolerability profile consistent with previously reported results. The Company is continuing its analysis of the PREVAIL dataset and is assessing the next steps for the development of BNC210 in SAD.

The Company continues to progress evaluation of BNC210 in patients with Post-Traumatic Stress Disorder (PTSD) in a randomised, double-blind, placebo-controlled, multi-center Phase 2b clinical trial with a 12-week treatment period recruiting approximately 200 patients. The ATTUNE study has been ongoing in the US, and new sites were recently opened for recruitment in the United Kingdom. The independent Safety Review Committee meets approximately every three months to monitor participant safety and to date, no safety concerns precluding continuation of the trial have been reported; topline results are expected in mid-2023.

Bionomics also continued to see progress in its partnership with Merck & Co (known as MSD outside the United States and Canada) to develop α7 receptor positive allosteric modulators (PAMs) targeting cognitive impairment in Alzheimer's disease with two compounds undergoing Phase 1 safety and biomarker clinical trials.

While the internal focus and current research and development spending are restricted to CNS programs, Bionomics continues limited activities to maximise the value of its legacy oncology programs through divestment and/or out-licensing both BNC101 and BNC105. Of the non-core legacy oncology assets, the development program established under the exclusive license agreement of BNC101 to Carina Biotech continued to advance and is projected by Carina to move into the clinic in 1H2023. There is also a Memorandum of Understanding that the Company entered into in February 2021 with EmpathBio for exploring a potential combination of BNC210 and EMP-01 (an MDMA derivative) for the treatment of PTSD.

Page 3 of 26

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In November 2022, the Company issued 614,026 American Depositary Shares ("ADS") in the United States at a price of US$7.80 per ADS, raising gross proceeds of US$5,000,000 ($7,419,235). The offering price of US$7.80 per ADS ($0.0641 per ordinary share) represented a 1.63% discount to the 15-day volume weighted average price. Each ADS represents 180 fully paid Bionomic ordinary shares and resulted in 115,384,680 fully paid shares being issued. The net proceeds raised were $5,806,168.

In December 2022, the Company announced a critical milestone for the leadership team with the appointment of Dr. Spyridon "Spyros" Papapetropoulos starting in January 2023 as Bionomics' President, Chief Executive Officer, and Director. In conjunction with this development, it was announced that Dr. Errol De Souza, who had been serving as Bionomics' Executive Chairman since November 2018, would be stepping back from the role and, in 1 January 2023 resumed the role of Non-Executive Chairman of the Board of Directors.

The Company's cash balance as of 31 December 2022 was $30,698,362 (30 June 2022: $35,564,857).

**FOR FURTHER INFORMATION, PLEASE CONTACT:**

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| | |
|:---|:---|
| **Bionomics Limited** | **Bionomics Limited** |
| Adrian Hinton | Ms Suzanne Irwin |
| Acting Chief Financial Officer | Company Secretary |
| +61 8 8150 7400 | +61 8 8150 7400 |
| ahinton@bionomics.com.au | <u>CoSec@bionomics.com.au</u> |

---

**About Bionomics Limited** 

Bionomics (ASX:BNO, NASDAQ:BNOX) is a clinical-stage biopharmaceutical company developing novel, allosteric ion channel modulators designed to transform the lives of patients suffering from serious central nervous system (CNS) disorders with high unmet medical need. Bionomics is advancing its lead drug candidate, BNC210, an oral, proprietary, selective negative allosteric modulator of the α7 nicotinic acetylcholine receptor, for the acute treatment of Social Anxiety Disorder (SAD) and chronic treatment of Post-Traumatic Stress Disorder (PTSD). Beyond BNC210, Bionomics has a strategic partnership with Merck & Co, Inc (known as MSD outside the United States and Canada) with two drugs in early-stage clinical trials for the treatment of cognitive deficits in Alzheimer's disease and other central nervous system conditions.

www.bionomics.com.au

**Factors Affecting Future Performance**

This announcement contains "forward-looking" statements within the meaning of the U.S. federal securities laws. Any statements contained in this announcement that relate to prospective events or developments, including, without limitation, statements related to the Offering are deemed to be forward-looking statements. Words such as "believes," "anticipates," "plans," "expects," "projects," "forecasts," "will" and similar expressions are intended to identify forward-looking statements. There are a number of important factors that could cause actual results or events to differ materially from those indicated by these forward-looking statements. The Company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events, or otherwise. Actual results could differ materially from those discussed in this ASX announcement.

Page 4 of 26

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![img65882896_2.jpg](img65882896_2.jpg)

ABN 53 075 582 740

**BIONOMICS LIMITED**

Half-Year Report – 31 December 2022

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| | |
|:---|:---|
| **Contents** | **Page** |
| <br>[<u>Directors' Report</u>](#directors_report) | <br>6 |
| <br><u>Auditor's Independence Declaration</u> | <br>11 |
| <br>[<u>Consolidated Statement of Profit or Loss and Other Comprehensive Income</u>](#condensed_consolidated_stmt_of_profit) | <br>12 |
| <br>[<u>Consolidated Statement of Financial Position</u>](#condensed_consolidated_statement_of_fina) | <br>13 |
| <br>[<u>Consolidated Statement of Changes in Equity</u>](#condensed_consoli_stmt_changes_in_equity) | <br>14 |
| <br>[<u>Consolidated Statement of Cash Flows</u>](#condensed_consolidate_stmt_of_cash_flows) | <br>15 |
| <br><u>Notes to the Consolidated Financial Statements</u> | <br>16 |
| <br>[<u>Directors' Declaration</u>](#directors_declaration) | <br>24 |
| <br>[<u>Independent Auditor's Review Report to the Members</u>](#independent_auditors_review_report) | <br>25 |

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This interim financial report does not include all the notes of the type normally included in an annual financial report. Accordingly, this report is to be read in conjunction with the annual report for the year ended 30 June 2022.

Page 5 of 26

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**BIONOMICS LIMITED**

**Directors' Report**

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Directors present their report on the consolidated entity (the Group) consisting of Bionomics Limited (the Company) and the entities it controlled at the end of, or during, the half-year that ended 31 December 2022. To comply with the provisions of the Corporations Act 2001, the Directors report as follows:

**Directors**

The names of the Directors of the Company during or since the end of the half-year:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Dr. Errol De Souza, Executive Chairman

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Mr. Alan Fisher, Non-Executive Director

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Mr. David Wilson, Non-Executive Director

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Dr. Jane Ryan, Non-Executive Director

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Mr. Aaron Weaver, Non-Executive Director

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Dr. Miles Davies, Non-Executive Director

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Dr. Spyridon Papapetropoulos, President and Chief Executive Officer

With the appointment of Dr. Spyridon Papapetropoulos on 5 January 2023, as President, Chief Executive Officer and Director, Dr. Errol De Souza resumed the role of non-Executive Chairman from 1 January 2023, previously being the Executive Chairman.

**Principal Activities**

The group's principal activities during the period include developing novel drug candidates focused on treating central nervous system disorders (CNS).

**Dividends** 

The Directors do not propose any recommendation for dividends for the current financial year.

**REVIEW OF OPERATING RESULTS**

Cash during the half-year to 31 December 2022, decreased by $2,866,495 to $30,698,362 at 31 December 2022, from $33,564,857 at 30 June 2022. The decrease is due to net decrease in cash from activities during the half-year ended 31 December 2022 of $2,863,424 and a foreign exchange loss from the effects of exchange rate changes on the balance of cash held in foreign currencies at 31 December 2022 of $3,071. The net decrease in cash from activities is due to the following:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•net cash used in operating activities of $9,008,936, due to payments to suppliers and employees of $15,713,558 and payments for finance costs of $15,139, offset by the receipt of research & development tax incentive of $6,719,761.

Offset by

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•net cash inflows from investing activities of $191,100 due to interest income received; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•cash inflows from financing activities of $5,954,411, due to net proceeds from share issues of $6,033,489 offset by principal element of lease payments of $79,077.

The operating loss after tax for the half-year ended 31 December 2022 increased to $16,207,967, compared to $13,053,471 for the half-year ended 31 December 2021, primarily as a result of:

Page 6 of 26

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Other income for the half-year increased by $148,062 to $325,054, compared to $176,992 for the previous half-year. The increase is primarily due to an increase in interest income, offset by a decrease in the Australian Government research and development tax incentive income.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Other gains and (losses) for the half-year increased by $1,081,167 to a net gain of $414,442, compared to a net loss of $666,725 for the previous half-year. The increase is primarily due to favorable movement in foreign exchange rates over the half-year ended 31 December 2022 resulting in a net realised and unrealised foreign currency gain.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Research and development expenses for the half-year increased by $3,804,879 to $10,760,153, compared to $6,955,274 for the previous half-year, as a result of the ATTUNE Phase 2b PTSD and PREVAIL Phase 2a clinical trials. For the current half-year, there have been two clinical trials compared to one during the previous half-year.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Administrative expenses for the half-year decreased by $555,728 to $4,081,012, compared to $4,636,740 for the previous half-year, primarily due to:

oa decrease in once-off expenses in the half-year. For the current period, there are none, whereas in the previous period, there were:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;▪fees paid to external consultants for the Contingent Value Rights (CVR) transaction that did not proceed; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;▪Initial public offering (IPO) audit costs that are not permitted to be recorded in issued capital and must be expensed.

oA decrease in the share-based payment expense from amortisation of share options over their vesting period; and

oa decrease in staff and consultant expenses.

Offset by:

oan increase in Executive Chairman's consulting fees due to the transitional payout and bonus payable as a result of the appointment of the new CEO;

oa new expense relating to obtaining assistance with the preparation of our 20F (legal and DFIN (program used to do the 20F)) for lodgment with the SEC in the United States as a result of listing on NASDAQ;

oan increase in staff recruitment expenses; and

oan increase in investor fees.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Compliance expenses increased by $1,209,902 to $2,083,933 compared to $874,031 for the previous half-year, primarily due to an increase in D&O insurance (as a result of listing on NASDAQ).

**REVIEW OF OPERATIONS**

Bionomics is a clinical-stage biopharmaceutical company developing novel, allosteric ion channel modulators designed to transform the lives of patients suffering from serious CNS disorders with high unmet medical need.

**Ion Channel Expertise to Drive Growth**

Ion channels serve as important mediators of physiological function in the CNS, and the modulation of ion channels influences neurotransmission that leads to downstream signaling in the brain. The a7 nicotinic acetylcholine (ACh) receptor (a7 receptor) is an ion channel that plays an essential role in driving emotional responses and cognitive performance. Utilising our ion channel and chemistry platforms, coupled with our allosteric modulation approach, we are developing orally active small molecule negative allosteric modulators (NAMs) and positive allosteric modulators (PAMs) of the a7 receptor to treat stress- and anxiety-related and cognitive disorders, respectively.

Page 7 of 26

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**BNC210 Pipeline Expansion and Continued Advancement**

Bionomics is advancing its lead product candidate, BNC210, an oral, proprietary selective NAM of the a7 receptor, for the acute treatment of Social Anxiety Disorder (SAD) and chronic treatment of Post-Traumatic Stress Disorder (PTSD).

The Company recently completed its Phase 2 PREVAIL Study to evaluate BNC210 for the acute treatment of SAD. The PREVAIL Study, initiated in January 2022, was a randomised, double-blind, placebo-controlled, multi-center Phase 2 clinical trial with a single dose treatment conducted at 15 sites in the US and recruited approximately 150 patients with SAD. The PREVAIL Study completed recruitment, and topline data were reported on 19 December 2022. The Company announced that while the primary endpoint, as measured by the change from baseline to the average of the Subjective Units of Distress Scale (SUDS) scores during a 5-minute Public Speaking Challenge was not met in the BNC210-treated patients when compared to placebo, the findings did indicate a consistent trend toward improvements across primary and secondary endpoints and a favourable safety and tolerability profile consistent with previously reported results. The Company is continuing its analysis of the PREVAIL dataset and is assessing the next steps for the development of BNC210 in SAD.

The Company continues to progress the evaluation of BNC210 in patients with Post-Traumatic Stress Disorder (PTSD) in a randomised, double-blind, placebo-controlled, multi-center Phase 2b clinical trial with a 12-week treatment period recruiting approximately 200 patients. The ATTUNE study has been ongoing in the US, and new sites were recently opened for recruitment in the United Kingdom. The independent Safety Review Committee meets approximately every three months to monitor participant safety with no safety concerns reported precluding continuation of the trial, and topline results are expected in mid-2023.

The Company's expertise and approach have been validated through its strategic partnership with MSD (known as Merck in the United States and Canada) for our a7 receptor PAM program, which targets a receptor that has garnered significant attention for treating cognitive deficits. This partnership enables Bionomics to maximise the value of its ion channel and chemistry platforms and develop transformative medicines for patients suffering from cognitive disorders such as Alzheimer's disease.

**Novel Approach in Large Market Opportunity with Significant Unmet Need**

There remains a significant unmet medical need for the over 22 million patients in the United States alone suffering from SAD and PTSD. Current pharmacological treatments include certain antidepressants and benzodiazepines, and there have been no new FDA-approved therapies in these indications in nearly two decades. These existing treatments have multiple shortcomings, such as a slow onset of action of antidepressants and significant side effects of both classes of drugs. BNC210 has been observed in clinical trials to have a fast onset of action and has demonstrated anti-anxiety and antidepressant effects but without many of the limiting side effects observed with the current standards of care for SAD and PTSD.

**Strong Ongoing Collaboration with MSD** 

Bionomics' collaboration with MSD for therapeutic candidates for the treatment of cognitive dysfunction in Alzheimer's disease and other conditions continues to progress through clinical development.

In June 2014, the Company entered into a research collaboration and license agreement with MSD to develop a7 receptor PAMs targeting cognitive impairment in conditions such as Alzheimer's disease, Parkinson's disease, schizophrenia, and attention deficit hyperactivity disorder (ADHD). Under the 2014 agreement, MSD is funding all research and development activities, including clinical development and worldwide commercialisation of any products developed from the collaboration. The Company received an upfront payment of US$20 million at the inception of the collaboration and another US$10 million in February 2017 when the first compound from the collaboration entered into

Page 8 of 26

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Phase 1 clinical trials and may receive up to an additional US$465 million in development and commercialisation milestone payments in addition to royalties from sales of the product(s) which range from mid-single digit to low double digit royalties.

The MSD collaboration currently includes two candidates in early-stage Phase 1 safety and biomarker clinical trials for treating cognitive impairment. The first compound has completed Phase 1 safety clinical trials in healthy subjects, and there are ongoing plans for further biomarker studies. In 2020, a second molecule that showed an improved potency profile in preclinical animal models was advanced by MSD under this collaboration into Phase 1 clinical trials.

**Leveraging the Value of Legacy Oncology Assets** 

Bionomics continued limited activities to maximise the value of our legacy oncology programs BNC101 and BNC105 through external funding of clinical development and divestment/out-licensing.

The Company entered into an exclusive agreement to license its BNC101 oncology drug candidate to Carina Biotech (Carina) for the development of Chimeric Antigen Receptor T cell (CAR-T) therapy, which harnesses the body's immune system to fight cancer. BNC101 is a first-in-class humanised monoclonal antibody to LGR5, which is overexpressed in cancer stem cells within solid tumors, including colorectal, breast, pancreatic, ovarian, lung, liver, and gastric cancers and has the potential to guide CAR-T therapeutic development. Under the worldwide exclusive License Agreement, Carina will fund all research and development activities. Bionomics is eligible to receive up to $118 million in clinical and development milestones plus royalty payments if Carina fully develops and markets the new therapy. In the event that Carina sub-licenses the CAR-T treatment, Bionomics is eligible to share in the sub-licensing revenues in early clinical development and receive a substantial double-digit portion of the revenues in the later stages of clinical development. On 24 January 2023, Carina announced that it had received an FDA "Safe to Proceed" Letter for a Phase 1/2a clinical trial of BNC101 CAR-T therapy for the treatment of advanced colorectal cancer and plans to commence patient enrollment during the first half of 2023.

**Financing Activities**

In November 2022 the Company filed a Form F-1 Registration Statement containing a Prospectus for an Offering of American Depositary Shares ("ADS") in the United States with the Security and Exchange Commission. The Company subsequently issued 614,026 ADS in the United States at a price of US$7.80 per ADS, raising gross proceeds of US$5,000,000 ($7,418,235). The offering price of US$7.80 per ADS ($0.0641 per ordinary share) represented a 1.63% discount to the volume weighted average price for the 15 days ending on 16 November 2022 on which trades of the Company's shares were recorded on the ASX. Each ADS represents 180 fully paid Bionomic ordinary shares and resulted in 115,384,680 fully paid shares being issued. The net proceeds raised were $5,806,168.

The net proceeds of the Offering, along with the existing cash and cash equivalents, are primarily being used to advance BNC210 through to the completion of the ongoing Phase 2b ATTUNE clinical trial, evaluating the next steps for the development of BNC210 in SAD, and for working capital and other research and development and general corporate purposes. Management continues to evaluate our capital requirements based on assumed activities and forecast expenditures.

**Subsequent Events**

Details about subsequent events are disclosed in Note 11 to the Half-year Report

Page 9 of 26

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**auditor's independence declaration**

A copy of the auditor's independence declaration, as required under section 307C of the Corporations Act 2001, is set out on page 11.

Signed in accordance with a resolution of the directors made pursuant to section 306(3) of the Corporations Act 2001.

On behalf of the directors

![img65882896_3.jpg](img65882896_3.jpg)

Spyridon "Spyros" Papapetropoulos

President, Chief Executive Officer and Director

Dated at Adelaide this 23 February 2023

Page 10 of 26

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| | | |
|:---|:---|:---|
| ![img65882896_4.jpg](img65882896_4.jpg)  | Ernst & Young<br>121 King William Street<br>Adelaide SA 5000 Australia<br>GPO Box 1271 Adelaide SA 5001 | Tel: +61 8 8417 1600<br>Fax: +61 8 8417 1775<br>ey.com/au |

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**Auditor's independence declaration to the directors of Bionomics Limited**

As lead auditor for the review of the half-year financial report of Bionomics Limited for the half-year ended 31 December 2022, I declare to the best of my knowledge and belief, there have been:

a.No contraventions of the auditor independence requirements of the Corporations Act 2001 in relation to the review;

b.No contraventions of any applicable code of professional conduct in relation to the review; and

c.No non-audit services provided that contravene any applicable code of professional conduct in relation to the review.

This declaration is in respect of Bionomics Limited and the entities it controlled during the financial period.

![img65882896_5.jpg](img65882896_5.jpg)

Ernst & Young

![img65882896_6.jpg](img65882896_6.jpg)

Nigel Stevenson

Partner

23 February 2023

A member firm of Ernst & Young Global Limited<br>Liability limited by a scheme approved under Professional Standards Legislation

Page 11 of 26

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**BIONOMICS LIMITED**

**Consolidated Statement of Profit or Loss and Other Comprehensive Income**

**for the half-year ended 31 December 2022**

------

---

| | | | |
|:---|:---|:---|:---|
|  |  | **<u>Half-year ended</u>** | **<u>Half-year ended</u>** |
|  | **<u>Note</u>** | **<u>31 Dec 2022</u>** | **<u>31 Dec 2021</u>** |
|  |  | **<u>$</u>** | **<u>$</u>** |
| **Continuing operations** |  |  |  |
| Other income | **2** | 325054 | 176992 |
| Other gains and (losses) | **2** | 414442 | (666725) |
| **Expenses** |  |  |  |
| Research and development expenses |  | (10760153) | (6955274) |
| Administration expenses |  | (4081012) | (4636740) |
| Occupancy expenses |  | (111149) | (166798) |
| Compliance expenses |  | (2083933) | (874031) |
| Finance expenses | **3** | (15139) | (25985) |
| **(Loss) before tax**  |  | (16311890 | (13148561) |
| Income tax benefit |  | 103923 | 95090 |
| **(Loss) for the period**  |  | (16207967) | (13053471) |
| **Other comprehensive income, net of income tax** |  |  |  |
| Items that may be reclassified subsequently to profit or loss: |  |  |  |
| Gain on exchange differences from translating foreign operations |  | 199913 | 394914 |
| **Total comprehensive (loss) for the period** |  | (16008054) | (12658557) |

---

---

| | | |
|:---|:---|:---|
| (Loss) per share from continuing operations:  | **<u>Cents</u>** | **<u>Cents</u>** |
| Basic (loss) per share | (1.2) | (1.3) |
| Diluted (loss) per share | (1.2) | (1.3) |

---

The above consolidated statement of profit or loss and other comprehensive income should be read in conjunction with the accompanying notes.

Page 12 of 26

------

**BIONOMICS LIMITED**

**Consolidated Statement of Financial Position**

**as at 31 December 2022**

------

---

| | | | |
|:---|:---|:---|:---|
|  | &nbsp;&nbsp;**Note** | &nbsp;&nbsp;**<u>31 Dec 2022</u>**<br>**<u>$</u>** | &nbsp;&nbsp;**<u>30 June 2022</u>**<br>**<u>$</u>** |
| &nbsp;&nbsp;**CURRENT ASSETS** |  |  |  |
| &nbsp;&nbsp;Cash and cash equivalents |  | &nbsp;&nbsp;30698362 | &nbsp;&nbsp;33564857 |
| &nbsp;&nbsp;Trade and other receivables |  | &nbsp;&nbsp;38033 | &nbsp;&nbsp;64360 |
| &nbsp;&nbsp;Research and development incentives receivable |  | &nbsp;&nbsp;132784 | &nbsp;&nbsp;6719761 |
| &nbsp;&nbsp;Prepayments |  | &nbsp;&nbsp;2280703 | &nbsp;&nbsp;1461268 |
| &nbsp;&nbsp;TOTAL CURRENT ASSETS |  | &nbsp;&nbsp;33149882 | &nbsp;&nbsp;41810246 |
| &nbsp;&nbsp;**NON-CURRENT ASSETS** |  |  |  |
| &nbsp;&nbsp;Property, plant and equipment |  | &nbsp;&nbsp;4482 | &nbsp;&nbsp;5172 |
| &nbsp;&nbsp;Right-of-use assets |  | &nbsp;&nbsp;583908 | &nbsp;&nbsp;669358 |
| &nbsp;&nbsp;Goodwill |  | &nbsp;&nbsp;12954792 | &nbsp;&nbsp;12868122 |
| &nbsp;&nbsp;Other intangible assets |  | &nbsp;&nbsp;9495342 | &nbsp;&nbsp;9838274 |
| &nbsp;&nbsp;Other financial assets |  | &nbsp;&nbsp;119000 | &nbsp;&nbsp;119000 |
| &nbsp;&nbsp;TOTAL NON-CURRENT ASSETS |  | &nbsp;&nbsp;23157524 | &nbsp;&nbsp;23499926 |
| &nbsp;&nbsp;**TOTAL ASSETS** |  | &nbsp;&nbsp;56307406 | &nbsp;&nbsp;65310172 |
| &nbsp;&nbsp;**CURRENT LIABILITIES** |  |  |  |
| &nbsp;&nbsp;Trade and other payables |  | &nbsp;&nbsp;3091265 | &nbsp;&nbsp;2786280 |
| &nbsp;&nbsp;Lease liabilities |  | &nbsp;&nbsp;165860 | &nbsp;&nbsp;160040 |
| &nbsp;&nbsp;Provisions |  | &nbsp;&nbsp;404566 | &nbsp;&nbsp;409320 |
| &nbsp;&nbsp;TOTAL CURRENT LIABILITIES |  | &nbsp;&nbsp;3661691 | &nbsp;&nbsp;3355640 |
| &nbsp;&nbsp;**NON-CURRENT LIABILITIES** |  |  |  |
| &nbsp;&nbsp;Lease liabilities |  | &nbsp;&nbsp;448686 | &nbsp;&nbsp;5335833 |
| &nbsp;&nbsp;Provisions |  | &nbsp;&nbsp;16419 | &nbsp;&nbsp;10460 |
| &nbsp;&nbsp;Deferred tax liabilities |  | &nbsp;&nbsp;1722695 | &nbsp;&nbsp;1798625 |
| &nbsp;&nbsp;Contingent consideration | &nbsp;&nbsp;**10** | &nbsp;&nbsp;2738517 | &nbsp;&nbsp;2699010 |
| &nbsp;&nbsp;TOTAL NON-CURRENT LIABILITIES |  | &nbsp;&nbsp;4926317 | &nbsp;&nbsp;5041678 |
| &nbsp;&nbsp;**TOTAL LIABILITIES** |  | &nbsp;&nbsp;8588008 | &nbsp;&nbsp;8397318 |
| &nbsp;&nbsp;**NET ASSETS** |  | &nbsp;&nbsp;47719398 | &nbsp;&nbsp;56912854 |
| &nbsp;&nbsp;**EQUITY** |  |  |  |
| &nbsp;&nbsp;Issued capital | &nbsp;&nbsp;**4** | &nbsp;&nbsp;223501927 | &nbsp;&nbsp;217695759 |
| &nbsp;&nbsp;Reserves |  | &nbsp;&nbsp;13446246 | &nbsp;&nbsp;12523598 |
| &nbsp;&nbsp;Accumulated losses |  | &nbsp;&nbsp;(189228775) | &nbsp;&nbsp;(173306503) |
| &nbsp;&nbsp;Total equity |  | &nbsp;&nbsp;47719398 | &nbsp;&nbsp;56912854 |

---

The above consolidated statement of financial position should be read in conjunction with the accompanying notes.

Page 13 of 26

------

**BIONOMICS LIMITED**

**Consolidated Statement of Changes in Equity**

**for the half-year ended 31 December 2022**

------

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
|  | **<u>Issued Capital</u>** | **<u>Foreign currency translation reserve</u>** | **<u>Share-</u>**<br>**<u>based payments reserve</u>** | **<u>Accumulated losses</u>** | **<u>Total</u>** |
|  | **<u>$</u>** | **<u>$</u>** | **<u>$</u>** | **<u>$</u>** | **<u>$</u>** |
| Balance 1 July 2021  | 190190147 | 5119200 | 6328691 | (154040501) | 47597537 |
| Loss for the period | - | - | - | (13053471) | (13053471) |
| Gain on exchange differences from translating foreign operations | - | 394914 | - | - | 394914 |
| Total comprehensive income for the period | - | 394914 | - | (13053471) | (12658557) |
| Issue of shares on exercise of options and warrants  | 834960 | - | (327760) | - | 507200 |
| Share placement as result of US IPO | 28159542 | - | - | - | 28159542 |
| Cost associated with share issue | (4939110) | - | - | - | (4939110) |
| Recognition of share-based payments | - | - | 1615270 | - | 1615270 |
| Transfer of lapsed share options | - | - | (2397831) | 2397831 | - |
| Balance at 31 December 2021 | **214245539** | **5514114** | **5218370** | **(164696141)** | **60281882** |
| Balance at 1 July 2022 | 217695759 | 6186333 | 6337264 | (173306503) | 56912853 |
| Loss for the period | - | - | - | (16207967) | (16207967) |
| Gain on exchange differences from translating foreign operations | - | 199913 | - | - | 199913 |
| Total comprehensive income for the period | - | 199913 | - | (16207967) | (16008054) |
| Share placement as result of US F-1 | 7419235 | - | - | - | 7419235 |
| Cost associated with share issues | (1613067) | - | - | - | (1613067) |
| Recognition of share-based payments | - | - | 1008431 | - | 1008431 |
| Transfer of lapsed share options and warrants | - | - | (285695) | 285695 | - |
| Balance at 31 December 2022 | **223501927** | **6386246** | **7060000** | **(189228775)** | **47719398** |

---

The above consolidated statement of changes in equity should be read in conjunction with the accompanying notes.

Page 14 of 26

------

**BIONOMICS LIMITED**

**Consolidated Statement of Cash Flows**

**for the half-year ended 31 December 2022**

------

---

| | | |
|:---|:---|:---|
|  |  | **Half-year ended** |
|  |  | **31 Dec 2022** |
|  | **Note** | **<u>$</u>** |
| **Cash flows from operating activities** |  |  |
| Research and development incentives received  |  | 6719761 |
| Receipts from customers  |  | - |
| Payments to suppliers and employees |  | (15713558) |
| Finance costs paid |  | (15139) |
| **Net cash (used in) operating activities** |  | **(9008936))** |
| **Cash flows from investing activities**<br>Interest received |  | 191100 |
| Proceeds from other financial assets (term deposits) |  | - |
| Payments for purchases of plant and equipment |  | - |
| Proceeds from sale of plant and equipment |  | - |
| **Net cash generated by investing activities** |  | **191100** |
| **Cash flows from financing activities** |  |  |
| Proceeds from share issues  |  | 7419235 |
| Payments for share issue costs |  | (1385746) |
| Principal elements of lease payments |  | (79077) |
| **Net cash generated by financing activities** |  | **5954412** |
| **Net (decrease)/increase in cash and cash equivalents** |  | **(2863424)** |
| Cash and cash equivalents at the beginning of the half-year |  | 33564857 |
| Effects of exchange rate changes on the balance of cash held in foreign currencies |  | (3071) |
| **Cash and cash equivalents at the end of the half-year** | **9** | **30698362** |

---

The above consolidated statement of cash flows should be read in conjunction with the accompanying notes.

Page 15 of 26

------

**BIONOMICS LIMITED**

**Notes to the Consolidated Financial Statements**

**for the half-year ended 31 December 2022**

------

**NOTE 1: Summary of significant accounting policies**

**(a)** **Statement of Compliance**

The half-year financial report is a general-purpose financial report prepared in accordance with the Corporations Act 2001 and AASB 134 'Interim Financial Reporting'. Compliance with AASB 134 ensures compliance with International Financial Reporting Standard IAS 34 'Interim Financial Reporting'. The half-year report does not include notes of the type normally included in an annual financial report and should be read in conjunction with the most recent annual financial report.

**(b)** **Basis of Preparation**

The consolidated financial statements have been prepared on the basis of historical cost, except for the contingent consideration liability which is measured at fair value at the end of each reporting period (Note 10). Cost is based on the fair values of the consideration given in exchange for assets. All amounts are presented in Australian dollars, unless otherwise noted.

The accounting policies and methods of computation adopted in the preparation of the half-year financial report are consistent with those adopted and disclosed in the Company's annual financial report for the financial year ended 30 June 2022 except for the impact of the Standards and Interpretations described below. These accounting policies are consistent with Australian Accounting Standards (AAS) and with International Financial Reporting Standards (IFRS).

**(c)** **New Accounting Standards and Interpretations**

The Group has adopted all the new and revised Standards and Interpretations issued by the Australian Accounting Standards Board (the AASB) that are relevant to its operations and effective for an accounting period that begins on or after 1 July 2022. The adoption of all new and revised Standards and Interpretations has not resulted in any significant changes to the Group's accounting policies and has no material effect on the amounts reported for the current or prior half-years.

**NOTE 2: other income and other gains and losses**

---

| | |
|:---|:---|
| &nbsp;&nbsp;**<u>Half-year ended</u>** | &nbsp;&nbsp;**<u>Half-year ended</u>** |
| &nbsp;&nbsp;**<u>31 Dec 2022</u>** | &nbsp;&nbsp;**<u>31 Dec 2021</u>** |

---

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;**Other income from continuing operations** | &nbsp;&nbsp;**<u>$</u>** | &nbsp;&nbsp;**<u>$</u>** |
| &nbsp;&nbsp;Rent | &nbsp;&nbsp;- | &nbsp;&nbsp;6674 |
| &nbsp;&nbsp;Interest income | &nbsp;&nbsp;192270 | &nbsp;&nbsp;951 |
| &nbsp;&nbsp;Government Research and Development Incentives (i) | &nbsp;&nbsp;132784 | &nbsp;&nbsp;169367 |
|  | &nbsp;&nbsp;325054 | &nbsp;&nbsp;176992 |

---

(i)The Government Research and Development Incentives relate to a cash refund provided by the Australian Government for 43.5% (31 December 2021: 43.5%) of eligible research and development expenditures by Australian entities having a tax loss and less than $20 million in revenue and is received after the 30 June 2022 tax return is lodged with the Australian Tax Office.

---

| | | |
|:---|:---|:---|
|  | &nbsp;&nbsp;**<u>Half-year ended</u>** | &nbsp;&nbsp;**<u>Half-year ended</u>** |
|  | &nbsp;&nbsp;**<u>31 Dec 2022</u>** | &nbsp;&nbsp;**<u>31 Dec 2021</u>** |
| &nbsp;&nbsp;**Other gains and (losses) from continuing operations** | &nbsp;&nbsp;**<u>$</u>** | &nbsp;&nbsp;**<u>$</u>** |
| &nbsp;&nbsp;Net (loss) arising on changes in fair value of contingent <br>consideration (Note 10) | &nbsp;&nbsp;(39507) | &nbsp;&nbsp;(54324) |
| &nbsp;&nbsp;Net realised and unrealised foreign currency gain/(loss) | &nbsp;&nbsp;453949 | &nbsp;&nbsp;(610575) |
| &nbsp;&nbsp;(Loss) on disposal of plant and equipment | &nbsp;&nbsp;- | &nbsp;&nbsp;(1826) |

---

Page 16 of 26

------

**BIONOMICS LIMITED**

**Notes to the Consolidated Financial Statements**

**for the half-year ended 31 December 2022**

------

<u>414,442</u> <u>(666,725)</u>

**NOTE 3: Finance Expense**

---

| | | |
|:---|:---|:---|
|  | &nbsp;&nbsp;**<u>Half-year ended</u>** | &nbsp;&nbsp;**<u>Half-year ended</u>** |
|  | &nbsp;&nbsp;**<u>31 Dec 2022</u>** | &nbsp;&nbsp;**<u>31 Dec 2021</u>** |
|  | &nbsp;&nbsp;**<u>$</u>** | &nbsp;&nbsp;**<u>$</u>** |
| &nbsp;&nbsp;Interest expense on lease liabilities | &nbsp;&nbsp;11335 | &nbsp;&nbsp;14179 |
| &nbsp;&nbsp;Bank fees | &nbsp;&nbsp;3804 | &nbsp;&nbsp;11806 |
|  | &nbsp;&nbsp;15139 | &nbsp;&nbsp;25985 |

---

**NOTE 4: Equity Securities Issued**

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **<u>Half-year</u>** | **<u>Half-year</u>** | **<u>Half-year</u>** | **<u>Half-year</u>** |
|  | **<u>31 Dec 2022</u>** | **<u>31 Dec 2021</u>** | **<u>31 Dec 2022</u>** | **<u>31 Dec 2021</u>** |
|  | **<u>Number of shares</u>** | **<u>Number of shares</u>** | <br>**<u>$</u>** | <br>**<u>$</u>** |
| **Ordinary shares** |  |  |  |  |
| Balance at the beginning of the half-year | 1353350744 | 1007596744 | 217695759 | 190190147 |
| Issue of shares on exercise of share options and warrants | - | 10000000 | - | 507200 |
| Transfer from share-based payments reserve | - | - | - | 327760 |
| US IPO share placement | - | 291960000  |  | 28159542 |
| Issue of shares US F-1 | 115384680 | - | 7419235 |  |
| Costs associated with share issues | - | - | (1613067) | (4939110) |
| **Total Issued Capital** | 1468735424 | 1309556744 | 223501927 | 214245539 |

---

**NOTE 5: share options and Warrants**

During the half-year ended 31 December 2022, no share options or warrants were exercised.

On 15 July 2022, the Company issued 7,700,000 share options to subscribe for 7,700,000 shares at $0.0543 per share, including 7,500,000 share options that were issued to key management personnel (KMP). 25% of the Options vest at the end of 12 months following the Offer Date (8 July 2022), and 75% vest in 12 substantially equal installments on the last day of each calendar quarter over the 3-year period following the end of the initial 12 months following the Offer Date. The share options expire on the date that is 5 years following each vesting date.

Details of share options that were issued to the KMPs are set out below:

---

| | |
|:---|:---|
| &nbsp;&nbsp;**KMP** | &nbsp;&nbsp;**Number** |
| &nbsp;&nbsp;Mr Adrian Hinton | &nbsp;&nbsp;2000000 |
| &nbsp;&nbsp;Mr Connor Bernstein | &nbsp;&nbsp;3500000 |
| &nbsp;&nbsp;Ms Liz Doolin | &nbsp;&nbsp;2000000 |
| &nbsp;&nbsp;**Total** | &nbsp;&nbsp;**7500000** |

---

Page 17 of 26

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**BIONOMICS LIMITED**

**Notes to the Consolidated Financial Statements**

**for the half-year ended 31 December 2022**

------

Details of the issue are set out below:

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| **Grant date** | **Vesting date** | **Expiry date** | **Exercise price** | **Number** | **Fair value of issue** |
| 15-Jul-22 | 8-Jul-23 | 8-Jul-28 | $0.0543 | 1925000 | $0.041 |
| 15-Jul-22 | 31-Oct-23 | 31-Oct-28 | $0.0543 | 481250 | $0.042 |
| 15-Jul-22 | 31-Jan-24 | 31-Jan-29 | $0.0543 | 481250 | $0.043 |
| 15-Jul-22 | 30-Apr-24 | 30-Apr-29 | $0.0543 | 481250 | $0.043 |
| 15-Jul-22 | 31-Jul-24 | 31-Jul-29 | $0.0543 | 481250 | $0.044 |
| 15-Jul-22 | 31-Oct-24 | 31-Oct-29 | $0.0543 | 481250 | $0.044 |
| 15-Jul-22 | 31-Jan-25 | 31-Jan-30 | $0.0543 | 481250 | $0.045 |
| 15-Jul-22 | 30-Apr-25 | 30-Apr-30 | $0.0543 | 481250 | $0.045 |
| 15-Jul-22 | 31-Jul-25 | 31-Jul-30 | $0.0543 | 481250 | $0.046 |
| 15-Jul-22 | 31-Oct-25 | 31-Oct-30 | $0.0543 | 481250 | $0.046 |
| 15-Jul-22 | 31-Jan-26 | 31-Jan-31 | $0.0543 | 481250 | $0.046 |
| 15-Jul-22 | 30-Apr-26 | 30-Apr-31 | $0.0543 | 481250 | $0.047 |
| 15-Jul-22 | 31-Jul 26 | 31-Jul 31 | $0.0543 | 481250 | $0.047 |
|  |  |  |  | 7700000 |  |

---

A Black-Scholes model was used to obtain the fair value of the above share options. Inputs used are summarised below:

---

| | |
|:---|:---|
| Share price at date of granting | $0.058 |
| Exercise price | $0.0543 |
| Bionomics share volatility | 80.13% |
| Risk free interest rate | 3.196% |

---

During the half-year ended 31 December 2022, 1,067,050 share options lapsed, details are set out below:

---

| | |
|:---|:---|
| &nbsp;&nbsp;**Number of share options** | &nbsp;&nbsp;**Exercise price** |
| &nbsp;&nbsp;200000 | &nbsp;&nbsp;$0.23495 |
| &nbsp;&nbsp;100000 | &nbsp;&nbsp;$0.28665 |
| &nbsp;&nbsp;105000 | &nbsp;&nbsp;$0.29125 |
| &nbsp;&nbsp;5000 | &nbsp;&nbsp;$0.35565 |
| &nbsp;&nbsp;368050 | &nbsp;&nbsp;$0.41365 |
| &nbsp;&nbsp;15000 | &nbsp;&nbsp;$0.40775 |
| &nbsp;&nbsp;5000 | &nbsp;&nbsp;$0.43115 |
| &nbsp;&nbsp;50000 | &nbsp;&nbsp;$0.48385 |
| &nbsp;&nbsp;100000 | &nbsp;&nbsp;$0.51255 |
| &nbsp;&nbsp;15000 | &nbsp;&nbsp;$0.57505 |
| &nbsp;&nbsp;104000 | &nbsp;&nbsp;$0.69605 |
| &nbsp;&nbsp;1067050 |  |

---

Page 18 of 26

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**BIONOMICS LIMITED**

**Notes to the Consolidated Financial Statements**

**for the half-year ended 31 December 2022**

------

During the half-year ended 31 December 2022, no warrants lapsed.

**NOTE 6: Change in Accounting Estimates**

There have been no material changes in the basis of accounting estimates since the last annual reporting date.

**NOTE 7: Contingencies and Commitments** 

There has been no change in contingent liabilities and commitments since the last annual reporting date.

**NOTE 8: Key Management Personnel**

As a result of Dr Spyridon Papapetropoulos commencing employment as President and Chief Executive Officer on 5 January 2023 (see Note 11(a) for details), Dr De Souza resumed the role as Non-executive Chairman from 1 January 2023. As per the agreement with Dr De Souza a transitional payment of US$351,376 and bonus payment of US$332,325 became payable. As at 31 December 2022 these amounts have been accrued and are included in "Trade and other payables" in the Consolidated Statement of Financial Position.

Details of share options that were issued to KMPs on 15 July 2022 are set out in Note 5.

There have been no other changes to remuneration arrangements of key management personnel from what was disclosed in the 2022 annual financial report.

**NOTE 9: CASH FLOW INFORMATION**

Cash and cash equivalents at the end of the reporting period as shown in the consolidated statement of cash flows can be reconciled to the related items in the consolidated statement of financial position as follows:

---

| | | |
|:---|:---|:---|
|  | **<u>Half-year ended</u>** | **<u>Half-year ended</u>** |
|  | **<u>31 Dec 2022</u>** | **<u>31 Dec 2021</u>** |
|  | **<u>$</u>** | **<u>$</u>** |
| Cash and cash equivalent | 30698362 | 40351584 |

---

**NOTE 10: FAIR VALUE OF FINANCIAL INSTRUMENTS**

The Group has no financial assets that are measured at fair value and the only financial liability that is measured at fair value is Contingent Consideration. The following table gives information about how the fair value of this financial liability is determined:

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **Fair Value as at** | **Fair Value as at** |  |  |  |  |
| **Financial Liabilities** | **31 December**<br>**2022**<br>**$** | **30 June 2022**<br>**$** | **Fair value hierarchy** | **Valuation technique** | **Significant unobservable inputs** | **Relationship of unobservable inputs to fair value** |
| Contingent consideration | 2738517 | 2699010 | Level 3 | Discounted cash flow | Discount rate of 25% (pre-tax)  | The higher the discount rate,  |

---

Page 19 of 26

------

**BIONOMICS LIMITED**

**Notes to the Consolidated Financial Statements**

**for the half-year ended 31 December 2022**

------

          <u>applied to milestone and royalty projections, probability adjusted revenue projections.</u> <u>the lower the value. The higher the possible revenue, the higher value.</u>

The carrying value of all other financial assets and liabilities approximate their fair value.

**Contingent Consideration**

During the year ended 30 June 2013, the Company acquired Eclipse Therapeutics, Inc (Eclipse) into its wholly owned subsidiary Bionomics, Inc. Part of the consideration are potential cash earn-outs to Eclipse security holders based on achieving late stage development success or partnering outcomes of the Eclipse asset that was acquired. This liability is recorded at fair value; information about the calculation of the fair value is set out above. Due to changes in the projected inputs, being the timing and quantum of expected cash outflow at 31 December 2022 the liability has increased by $39,507 from the 30 June 2022 balance.

<u>Reconciliation of Level 3 Fair Value Measurements</u>

---

| | | |
|:---|:---|:---|
|  | **<u>Half-year ended</u>** | **<u>Half-year ended</u>** |
|  | **<u>Contingent consideration</u>** | **<u>Contingent consideration</u>** |
|  | **<u>31 Dec 2022</u>** | **<u>31 Dec 2021</u>** |
|  | **<u>$</u>** | **<u>$</u>** |
| Opening balance | 2699010 | 1762656 |
| Total (gain)/loss: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;recognised under "other gains or (losses)" in the Statement of Profit or Loss and Other Comprehensive Income | 39507 | 54324 |
| Closing balance | 2738517 | 1816980 |

---

**NOTE 11: SUBSEQUENT EVENTS**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a)On 5 January 2023, Dr Spyridon Papapetropoulos commenced employment as President and Chief Executive Officer, details of the employment contract are set out below:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Fixed Remuneration of US$525,000 per year base salary, plus reimbursement for the cost of procuring health benefits in the United States for an amount equal to US$2,500 per month.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Signing on bonus of US$50,000.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•A short-term incentive/bonus potential of 50% of base salary, upon meeting the applicable performance criteria established by the Remuneration Committee of the Board, against agreed financial, strategic and operational targets.

oA long-term incentive of 27,067,015 share options. See (c) below for details.

oFor termination for cause or voluntary resignation without good reason, pay earned but unpaid base salary and annual bonus.

oFor termination without cause or resignation for good reason:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Severance pay of 1 times base salary plus a 1 time target bonus potential to be paid in equal instalments over the following 12-month period, and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•any outstanding equity compensation awards will fully and immediately vest.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b)Shareholders at the General Meeting held on 21 February 2023 approved the issue of 10,000,000 share options to Dr De Souza (Non-executive Chairman) as part of his

Page 20 of 26

------

**BIONOMICS LIMITED**

**Notes to the Consolidated Financial Statements**

**for the half-year ended 31 December 2022**

------

renumeration as Executive Chairman to 31 December 2022 to subscribe for 10,000,000 shares at $0.052 per share. The options will be issued at a nil issue price. Upon exercise and payment of the exercise price, each option will convert into one fully paid ordinary share in the Company and rank equally with other fully paid ordinary shares in the Company on issue. Additionally, at the discretion of the Board, American Depositary Shares ("ADSs") in an amount equal to the number of shares which otherwise would be distributed pursuant to the exercise of the options, may be distributed in lieu of shares. If the number of shares represented by an ADS is other than on a one-to-one basis, the options will be adjusted to reflect the distribution of ADS's in lieu of shares.

The options will vest subject to Dr De Souza remaining a Director of the Company at the time of satisfaction of the vesting conditions set out below, or, in the case of Dr De Souza:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•not being nominated or recommended by the Board for re-election as a Director; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•not being re-elected to the Board,

and if the relevant options vest within 24 months of Dr De Souza ceasing to be a Director.

The vesting conditions are:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•5,000,000 options – to vest when (1) the volume weighted average trading price of the shares on ASX over the prior 20 days on which sales of shares were recorded on the ASX exceeds $0.0964 per share; or (2) the volume weighted average price of ADSs on NASDAQ over the prior 20 days on which sales of ADSs were recorded on NASDAQ exceeds US$12.35 per ADS, and in each case for (1) and (2) provided the relevant calculation period ends on or before 30 June 2024.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•1,666,666 options – to vest on achievement of successful data readout for Phase 2 trial for BNC210 in SAD as reasonably determined by the Board in its sole discretion.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•1,666,666 options – to vest on achievement of successful data readout for Phase 2 trial for BNC210 in PTSD as reasonably determined by the Board in its sole discretion.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•1,666,666 options – to vest if the Company appoints a Chief Executive Officer on or before 31 December 2022.

The exercise period for the options will commence on the date of vesting of the respective tranches of options, and end on the date that is five years following each vesting date. Any unvested options will expire immediately upon Dr De Souza ceasing to be an employee or Non-executive Director of the Company. Expiration will result in immediate forfeiture of all unexercised Options.

As at the date of this report the options have not been issued and will be issued within one month of shareholder approval.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;c) Shareholders at the General Meeting held on 21 February 2023 approved the issue of

27,067,015 share options to Dr Spyridon Papapetropoulos (President, Chief Executive Officer and a Director) to subscribe for 27,067,015 shares at $0.0321 per share. The options will be issued at a nil issue price. Upon exercise and payment of the exercise price, each Option will convert into one fully paid ordinary share in the Company and rank equally with other fully paid ordinary shares in the Company on issue. Additionally, at the discretion of the Board, ADSs in an amount equal to the number of shares which otherwise would be distributed pursuant to the exercise of the options may be distributed in lieu of shares. If the number of shares represented by an ADS is other than on a one-to-one basis, the options will be adjusted to reflect the distribution of ADS's in lieu of shares.

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**BIONOMICS LIMITED**

**Notes to the Consolidated Financial Statements**

**for the half-year ended 31 December 2022**

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The options will vest 25% on the first anniversary of the grant date for the options, with the balance vesting on a quarterly basis over a 3-year period commencing from that date, in each case, subject to continued service with the Company through each applicable vesting date or accelerated vesting in the event of involuntary termination.

The exercise period for the options will commence on the date of vesting of the respective tranches of options, and end on the date that is five years following each vesting date.

As at the date of this report the share options have not been issued and will be issued within one month of shareholder approval.

**NOTE 12: Segment Information**

The Group operates in one segment being "drug development" in Australia. This is the basis on which its internal reports are reviewed and used by the Board of Directors (the "chief operating decision maker") in monitoring, assessing performance and in determining the allocation of resources.

The results, assets and liabilities from this segment are equivalent to the consolidated financial statements.

**NOTE 13: IMPACT OF COVID-19**

The Board and Management have considered the impact of COVID-19 on the Company's operations and financial performance. Overall, operations for the half-year ended 31 December 2022 have not been materially affected by the COVID-19 pandemic.

The Phase 2b ATTUNE PTSD clinical trial started during July 2021 and is ongoing. The Phase 2 PREVAIL SAD clinical trial started during January 2022 and top line data readout was in December 2022, as was expected. To date Bionomics has not been notified by the Contract Research Organisation (who are managing the trials) of any material issues arising from COVID-19. However, there may be disruptions caused by the COVID-19 pandemic that may result in increased costs and delays in completing clinical trials. The Company is working closely with its clinical partners and has taken the necessary steps to allow for adjustments, where possible, in the clinical trial protocols should they be required due to restrictions that may be imposed during the COVID-19 pandemic.

The Company cannot predict the scope and severity of any further disruptions as a result of COVID-19 or its impact on the business. Unforeseen disruptions to the business or any of the third parties we use, including the collaborators, contract organisations, manufacturers, suppliers, clinical trial sites, and regulators, could materially and negatively impact our ability to conduct business in the manner and on the timelines presently planned. The extent to which COVID-19 pandemic may continue to impact the business and financial performance will depend on future developments, which are highly uncertain and cannot be predicted with confidence. Currently, the Company is unable to determine the extent of the impact of the pandemic on the clinical trials, operations and financial performance going forward. These

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**BIONOMICS LIMITED**

**Notes to the Consolidated Financial Statements**

**for the half-year ended 31 December 2022**

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developments are highly uncertain and unpredictable and may materially adversely affect the Company's future operating results and financial position.

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**BIONOMICS LIMITED**

**Directors' Declaration**

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In accordance with a resolution of the Directors of Bionomics Limited, I state that:

In the opinion of the Directors:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)the interim financial statements and notes of the Company and its subsidiaries (collectively the Group) are in accordance with the Corporations Act 2001, including:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;i.giving a true and fair view of the Group's financial position as at 31 December 2022

and of its performance for the half-year ended on that date; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ii.complying with Australian Accounting Standard AASB 134 Interim Financial Reporting and the Corporations Regulations 2001; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)there are reasonable grounds to believe that the Company will be able to pay its debts as and when they become due and payable

On behalf of the Directors

![img65882896_7.jpg](img65882896_7.jpg)

Spyridon "Spyros" Papapetropoulos <br> President, Chief Executive Officer and Director

Adelaide, 23 February 2023

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| | | |
|:---|:---|:---|
| ![img65882896_8.jpg](img65882896_8.jpg)  | Ernst & Young<br>121 King William Street<br>Adelaide SA 5000 Australia<br>GPO Box 1271 Adelaide SA 5001 | Tel: +61 8 8417 1600<br>Fax: +61 8 8417 1775<br>ey.com/au |

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**Independent auditor's review report to the members of Bionomics Limited**

**Report on the half-year financial report**

**Conclusion**

We have reviewed the accompanying half-year financial report of Bionomics Limited (the Company) and its subsidiaries (collectively the Group), which comprises the consolidated statement of financial position as at 31 December 2022, the consolidated statement of profit or loss and other comprehensive income, consolidated statement of changes in equity and consolidated statement of cash flows for the half-year ended on that date, notes comprising a summary of significant accounting policies and other explanatory information, and the directors' declaration.

Based on our review, which is not an audit, nothing has come to our attention that causes us to believe that the half-year financial report of the Group is not in accordance with the Corporations Act 2001, including:

a.Giving a true and fair view of the consolidated financial position of the Group as at 31 December 2022 and of its consolidated financial performance for the half-year ended on that date; and

b.Complying with Accounting Standard AASB 134 Interim Financial Reporting and the Corporations Regulations 2001.

**Basis for conclusion**

We conducted our review in accordance with ASRE 2410 Review of a Financial Report Performed by the Independent Auditor of the Entity (ASRE 2410). Our responsibilities are further described in the Auditor's responsibilities for the review of the half-year financial report section of our report. We are independent of the Group in accordance with the auditor independence requirements of the Corporations Act 2001 and the ethical requirements of the Accounting Professional and Ethical Standards Board's APES 110 Code of Ethics for Professional Accountants (including Independence Standards) (the Code) that are relevant to our audit of the annual financial report in Australia. We have also fulfilled our other ethical responsibilities in accordance with the Code.

**Directors' responsibilities for the half-year financial report** 

The directors of the Company are responsible for the preparation of the half-year financial report that gives a true and fair view in accordance with Australian Accounting Standards and the Corporations Act 2001 and for such internal control as the directors determine is necessary to enable the preparation of the half-year financial report that is free from material misstatement, whether due to fraud or error.

**Auditor's responsibilities for the review of the half-year financial report** 

Our responsibility is to express a conclusion on the half-year financial report based on our review. ASRE 2410 requires us to conclude whether we have become aware of any matter that makes us believe that the half-year financial report is not in accordance with the Corporations Act 2001

A member firm of Ernst & Young Global Limited<br>Liability limited by a scheme approved under Professional Standards Legislation

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![img65882896_8.jpg](img65882896_8.jpg) <br>

including giving a true and fair view of the Group's financial position as at 31 December 2022 and its performance for the half-year ended on that date, and complying with Accounting Standard AASB 134 Interim Financial Reporting and the Corporations Regulations 2001.

A review of a half-year financial report consists of making enquiries, primarily of persons responsible for financial and accounting matters, and applying analytical and other review procedures. A review is substantially less in scope than an audit conducted in accordance with Australian Auditing Standards and consequently does not enable us to obtain assurance that we would become aware of all significant matters that might be identified in an audit. Accordingly, we do not express an audit opinion.

![img65882896_9.jpg](img65882896_9.jpg)

Ernst & Young

![img65882896_10.jpg](img65882896_10.jpg)

Nigel Stevenson

Partner

Adelaide

23 February 2023

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