# EDGAR Filing Document

**Accession Number:** 0001906594
**File Stem:** 0001906594-26-000001
**Filing Date:** 2026-1
**Character Count:** 55249
**Document Hash:** d6e3894539502c611af8054c4854dc9d
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001906594-26-000001.hdr.sgml**: 20260129

**ACCESSION NUMBER**: 0001906594-26-000001

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20251231

**FILED AS OF DATE**: 20260129

**DATE AS OF CHANGE**: 20260128

**EFFECTIVENESS DATE**: 20260129

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** China Universal Asset Management Co., Ltd.
- **CENTRAL INDEX KEY:** 0001906594

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** F4
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-21774
- **FILM NUMBER:** 26574204

**BUSINESS ADDRESS:**
- **STREET 1:** CUAM BUILDING,728 WAIMA ROAD
- **CITY:** SHANGHAI
- **STATE:** F4
- **ZIP:** 200001
- **BUSINESS PHONE:** 862128932888

**MAIL ADDRESS:**
- **STREET 1:** CUAM BUILDING,728 WAIMA ROAD
- **CITY:** SHANGHAI
- **STATE:** F4
- **ZIP:** 200001

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2025

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** China Universal Asset Management Co. Ltd.<br>**Address:** CUAM BUILDING728 WAIMA ROAD<br>SHANGHAI, F4 200001

**Form 13F File Number:** 028-21774

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Li Peng<br>**Title:** Chief Compliance Officer<br>**Phone:** 011-86-21-20373399

**Signature, Place, and Date of Signing:**

Li Peng  Shanghai, F4  01-28-2026<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 497

**Form 13F Information Table Value Total:** $1302386778

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| APPLE INC | Common Stock | 037833100 |  | 66053009 | 242967 | SH |  | SOLE |  | 242967 | 0 | 0 |
| ANALOG DEVICES INC | Common Stock | 032654105 |  | 8192138 | 30207 | SH |  | SOLE |  | 30207 | 0 | 0 |
| AUTODESK INC | Common Stock | 052769106 |  | 3019006 | 10199 | SH |  | SOLE |  | 10199 | 0 | 0 |
| ASTERA LABS INC | Common Stock | 04626A103 |  | 698712 | 4200 | SH |  | SOLE |  | 4200 | 0 | 0 |
| ADVANCED MICRO DEVICES | Common Stock | 007903107 |  | 15077292 | 70402 | SH |  | SOLE |  | 70402 | 0 | 0 |
| AMAZON.COM INC | Common Stock | 023135106 |  | 49413022 | 214076 | SH |  | SOLE |  | 214076 | 0 | 0 |
| AMPHENOL CORP-CL A | Common Stock | 032095101 |  | 6362380 | 47000 | SH |  | SOLE |  | 47000 | 0 | 0 |
| APPLOVIN CORP-CLASS A | Common Stock | 03831W108 |  | 12671185 | 18805 | SH |  | SOLE |  | 18805 | 0 | 0 |
| BROADCOM INC | Common Stock | 11135F101 |  | 39865529 | 115185 | SH |  | SOLE |  | 115185 | 0 | 0 |
| BOOKING HOLDINGS INC | Common Stock | 09857L108 |  | 8150812 | 1522 | SH |  | SOLE |  | 1522 | 0 | 0 |
| CADENCE DESIGN SYS INC | Common Stock | 127387108 |  | 3470576 | 11103 | SH |  | SOLE |  | 11103 | 0 | 0 |
| CELESTICA INC | Common Stock | 15101Q207 |  | 3579837 | 12110 | SH |  | SOLE |  | 12110 | 0 | 0 |
| COHERENT CORP | Common Stock | 19247G107 |  | 2267258 | 12284 | SH |  | SOLE |  | 12284 | 0 | 0 |
| CREDO TECHNOLOGY GROUP HOLDI | Common Stock | G25457105 |  | 1510845 | 10500 | SH |  | SOLE |  | 10500 | 0 | 0 |
| CROWDSTRIKE HOLDINGS INC - A | Common Stock | 22788C105 |  | 4641662 | 9902 | SH |  | SOLE |  | 9902 | 0 | 0 |
| DOORDASH INC - A | Common Stock | 25809K105 |  | 4812474 | 21249 | SH |  | SOLE |  | 21249 | 0 | 0 |
| DATADOG INC - CLASS A | Common Stock | 23804L103 |  | 2082007 | 15310 | SH |  | SOLE |  | 15310 | 0 | 0 |
| ALPHABET INC-CL A | Common Stock | 02079K305 |  | 54447602 | 173954 | SH |  | SOLE |  | 173954 | 0 | 0 |
| INTEL CORP | Common Stock | 458140100 |  | 6383147 | 172985 | SH |  | SOLE |  | 172985 | 0 | 0 |
| INTUIT INC | Common Stock | 461202103 |  | 9076479 | 13702 | SH |  | SOLE |  | 13702 | 0 | 0 |
| KLA CORP | Common Stock | 482480100 |  | 10021980 | 8248 | SH |  | SOLE |  | 8248 | 0 | 0 |
| LUMENTUM HOLDINGS INC | Common Stock | 55024U109 |  | 4201557 | 11399 | SH |  | SOLE |  | 11399 | 0 | 0 |
| LAM RESEARCH CORP | Common Stock | 512807306 |  | 9339468 | 54487 | SH |  | SOLE |  | 54487 | 0 | 0 |
| MASTERCARD INC - A | Common Stock | 57636Q104 |  | 5190441 | 9092 | SH |  | SOLE |  | 9092 | 0 | 0 |
| MERCADOLIBRE INC | Common Stock | 58733R102 |  | 4582442 | 2275 | SH |  | SOLE |  | 2275 | 0 | 0 |
| META PLATFORMS INC-CLASS A | Common Stock | 30303M102 |  | 36145868 | 54759 | SH |  | SOLE |  | 54759 | 0 | 0 |
| MONDAY.COM LTD | Common Stock | M7S64H106 |  | 664020 | 4500 | SH |  | SOLE |  | 4500 | 0 | 0 |
| MICROSOFT CORP | Common Stock | 594918104 |  | 69862778 | 144458 | SH |  | SOLE |  | 144458 | 0 | 0 |
| MICRON TECHNOLOGY INC | Common Stock | 595112103 |  | 16353642 | 57278 | SH |  | SOLE |  | 57278 | 0 | 0 |
| NETFLIX INC | Common Stock | 64110L106 |  | 18751062 | 199990 | SH |  | SOLE |  | 199990 | 0 | 0 |
| SERVICENOW INC | Common Stock | 81762P102 |  | 2496997 | 16300 | SH |  | SOLE |  | 16300 | 0 | 0 |
| NVIDIA CORP | Common Stock | 67066G104 |  | 85498687 | 458438 | SH |  | SOLE |  | 458438 | 0 | 0 |
| ORACLE CORP | Common Stock | 68389X105 |  | 1824358 | 9360 | SH |  | SOLE |  | 9360 | 0 | 0 |
| PALO ALTO NETWORKS INC | Common Stock | 697435105 |  | 6911921 | 37524 | SH |  | SOLE |  | 37524 | 0 | 0 |
| PALANTIR TECHNOLOGIES INC-A | Common Stock | 69608A108 |  | 16011187 | 90077 | SH |  | SOLE |  | 90077 | 0 | 0 |
| RUBRIK INC-A | Common Stock | 781154109 |  | 650080 | 8500 | SH |  | SOLE |  | 8500 | 0 | 0 |
| REDDIT INC-CL A | Common Stock | 75734B100 |  | 574675 | 2500 | SH |  | SOLE |  | 2500 | 0 | 0 |
| RAMBUS INC | Common Stock | 750917106 |  | 643230 | 7000 | SH |  | SOLE |  | 7000 | 0 | 0 |
| SHOPIFY INC - CLASS A | Common Stock | 82509L107 |  | 9062289 | 56298 | SH |  | SOLE |  | 56298 | 0 | 0 |
| SANDISK CORP | Common Stock | 80004C200 |  | 878306 | 3700 | SH |  | SOLE |  | 3700 | 0 | 0 |
| SNOWFLAKE INC | Common Stock | 833445109 |  | 1338096 | 6100 | SH |  | SOLE |  | 6100 | 0 | 0 |
| SYNOPSYS INC | Common Stock | 871607107 |  | 6956553 | 14810 | SH |  | SOLE |  | 14810 | 0 | 0 |
| SPOTIFY TECHNOLOGY SA | Common Stock | L8681T102 |  | 1277562 | 2200 | SH |  | SOLE |  | 2200 | 0 | 0 |
| ATLASSIAN CORP-CL A | Common Stock | 049468101 |  | 1306038 | 8055 | SH |  | SOLE |  | 8055 | 0 | 0 |
| TERADYNE INC | Common Stock | 880770102 |  | 1006512 | 5200 | SH |  | SOLE |  | 5200 | 0 | 0 |
| TTM TECHNOLOGIES | Common Stock | 87305R109 |  | 1587000 | 23000 | SH |  | SOLE |  | 23000 | 0 | 0 |
| UBER TECHNOLOGIES INC | Common Stock | 90353T100 |  | 2971384 | 36365 | SH |  | SOLE |  | 36365 | 0 | 0 |
| VISA INC-CLASS A SHARES | Common Stock | 92826C839 |  | 11197820 | 31929 | SH |  | SOLE |  | 31929 | 0 | 0 |
| VERTIV HOLDINGS CO-A | Common Stock | 92537N108 |  | 1015965 | 6271 | SH |  | SOLE |  | 6271 | 0 | 0 |
| WORKDAY INC-CLASS A | Common Stock | 98138H101 |  | 2400811 | 11178 | SH |  | SOLE |  | 11178 | 0 | 0 |
| WESTERN DIGITAL CORP | Common Stock | 958102105 |  | 2269657 | 13175 | SH |  | SOLE |  | 13175 | 0 | 0 |
| ZETA GLOBAL HOLDINGS CORP-A | Common Stock | 98956A105 |  | 447700 | 22000 | SH |  | SOLE |  | 22000 | 0 | 0 |
| ZSCALER INC | Common Stock | 98980G102 |  | 1509888 | 6713 | SH |  | SOLE |  | 6713 | 0 | 0 |
| ASML HOLDING NV-NY REG SHS | NY Reg Shrs | N07059210 |  | 3192462 | 2984 | SH |  | SOLE |  | 2984 | 0 | 0 |
| ALIBABA GROUP HOLDING-SP ADR | ADR | 01609W102 |  | 3266096 | 22282 | SH |  | SOLE |  | 22282 | 0 | 0 |
| KANZHUN LTD - ADR | ADR | 48553T106 |  | 1161660 | 57000 | SH |  | SOLE |  | 57000 | 0 | 0 |
| FUTU HOLDINGS LTD-ADR | ADR | 36118L106 |  | 2584665 | 15740 | SH |  | SOLE |  | 15740 | 0 | 0 |
| JOYY INC-ADR | ADR | 46591M109 |  | 777120 | 12000 | SH |  | SOLE |  | 12000 | 0 | 0 |
| NETEASE INC-ADR | ADR | 64110W102 |  | 3591882 | 26100 | SH |  | SOLE |  | 26100 | 0 | 0 |
| PDD HOLDINGS INC | ADR | 722304102 |  | 4541496 | 40052 | SH |  | SOLE |  | 40052 | 0 | 0 |
| SAP SE-SPONSORED ADR | ADR | 803054204 |  | 2429100 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| SEA LTD-ADR | ADR | 81141R100 |  | 2691727 | 21100 | SH |  | SOLE |  | 21100 | 0 | 0 |
| TAL EDUCATION GROUP- ADR | ADR | 874080104 |  | 894620 | 82000 | SH |  | SOLE |  | 82000 | 0 | 0 |
| TRIP.COM GROUP LTD-ADR | ADR | 89677Q107 |  | 3429028 | 47685 | SH |  | SOLE |  | 47685 | 0 | 0 |
| TENCENT MUSIC ENTERTAINM-ADR | ADR | 88034P109 |  | 1614513 | 92100 | SH |  | SOLE |  | 92100 | 0 | 0 |
| TAIWAN SEMICONDUCTOR-SP ADR | ADR | 874039100 |  | 8189452 | 26893 | SH |  | SOLE |  | 26893 | 0 | 0 |
| VNET GROUP INC-ADR | ADR | 90138A103 |  | 253800 | 30000 | SH |  | SOLE |  | 30000 | 0 | 0 |
| FULL TRUCK ALLIANCE -SPN ADR | ADR | 35969L108 |  | 2006510 | 187000 | SH |  | SOLE |  | 187000 | 0 | 0 |
| AGILENT TECHNOLOGIES INC | Common Stock | 00846U101 |  | 340175 | 2500 | SH |  | SOLE |  | 2500 | 0 | 0 |
| ABBVIE INC | Common Stock | 00287Y109 |  | 1623650 | 7106 | SH |  | SOLE |  | 7106 | 0 | 0 |
| ABSCI CORP | Common Stock | 00091E109 |  | 120415 | 34503 | SH |  | SOLE |  | 34503 | 0 | 0 |
| ADAPTIVE BIOTECHNOLOGIES | Common Stock | 00650F109 |  | 429986 | 26477 | SH |  | SOLE |  | 26477 | 0 | 0 |
| ALIGN TECHNOLOGY INC | Common Stock | 016255101 |  | 20768 | 133 | SH |  | SOLE |  | 133 | 0 | 0 |
| AMGEN INC | Common Stock | 031162100 |  | 23413794 | 71534 | SH |  | SOLE |  | 71534 | 0 | 0 |
| AMN HEALTHCARE SERVICES INC | Common Stock | 001744101 |  | 47280 | 3000 | SH |  | SOLE |  | 3000 | 0 | 0 |
| ANAPTYSBIO INC | Common Stock | 032724106 |  | 364182 | 7512 | SH |  | SOLE |  | 7512 | 0 | 0 |
| ANNEXON INC | Common Stock | 03589W102 |  | 181142 | 36084 | SH |  | SOLE |  | 36084 | 0 | 0 |
| ARROWHEAD PHARMACEUTICALS IN | Common Stock | 04280A100 |  | 2000331 | 30130 | SH |  | SOLE |  | 30130 | 0 | 0 |
| ALPHATEC HOLDINGS INC | Common Stock | 02081G201 |  | 105200 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| AXOGEN INC | Common Stock | 05463X106 |  | 98190 | 3000 | SH |  | SOLE |  | 3000 | 0 | 0 |
| BIOHAVEN LTD | Common Stock | G1110E107 |  | 90320 | 8000 | SH |  | SOLE |  | 8000 | 0 | 0 |
| BRISTOL-MYERS SQUIBB CO | Common Stock | 110122108 |  | 863040 | 16000 | SH |  | SOLE |  | 16000 | 0 | 0 |
| BOSTON SCIENTIFIC CORP | Common Stock | 101137107 |  | 953500 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| CAMP4 THERAPEUTICS CORP | Common Stock | 13463J101 |  | 61300 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| CROSS COUNTRY HEALTHCARE INC | Common Stock | 227483104 |  | 24300 | 3000 | SH |  | SOLE |  | 3000 | 0 | 0 |
| THE CIGNA GROUP | Common Stock | 125523100 |  | 688075 | 2500 | SH |  | SOLE |  | 2500 | 0 | 0 |
| CRISPR THERAPEUTICS AG | Common Stock | H17182108 |  | 1076541 | 20529 | SH |  | SOLE |  | 20529 | 0 | 0 |
| CORVUS PHARMACEUTICALS INC | Common Stock | 221015100 |  | 139901 | 18169 | SH |  | SOLE |  | 18169 | 0 | 0 |
| CVS HEALTH CORP | Common Stock | 126650100 |  | 1269760 | 16000 | SH |  | SOLE |  | 16000 | 0 | 0 |
| QUEST DIAGNOSTICS INC | Common Stock | 74834L100 |  | 277648 | 1600 | SH |  | SOLE |  | 1600 | 0 | 0 |
| DIAMEDICA THERAPEUTICS INC | Common Stock | 25253X207 |  | 28656 | 3600 | SH |  | SOLE |  | 3600 | 0 | 0 |
| DESIGN THERAPEUTICS INC | Common Stock | 25056L103 |  | 321565 | 34282 | SH |  | SOLE |  | 34282 | 0 | 0 |
| DEXCOM INC | Common Stock | 252131107 |  | 931636 | 14037 | SH |  | SOLE |  | 14037 | 0 | 0 |
| ELEVANCE HEALTH INC | Common Stock | 036752103 |  | 701100 | 2000 | SH |  | SOLE |  | 2000 | 0 | 0 |
| EVOMMUNE INC | Common Stock | 30054Y107 |  | 34240 | 2000 | SH |  | SOLE |  | 2000 | 0 | 0 |
| EYEPOINT INC | Common Stock | 30233G209 |  | 538782 | 29490 | SH |  | SOLE |  | 29490 | 0 | 0 |
| MONTE ROSA THERAPEUTICS INC | Common Stock | 61225M102 |  | 291820 | 18611 | SH |  | SOLE |  | 18611 | 0 | 0 |
| GLOBUS MEDICAL INC - A | Common Stock | 379577208 |  | 174620 | 2000 | SH |  | SOLE |  | 2000 | 0 | 0 |
| GOSSAMER BIO INC | Common Stock | 38341P102 |  | 147920 | 47716 | SH |  | SOLE |  | 47716 | 0 | 0 |
| GRAIL INC | Common Stock | 384747101 |  | 680612 | 7952 | SH |  | SOLE |  | 7952 | 0 | 0 |
| HUMANA INC | Common Stock | 444859102 |  | 411003 | 1600 | SH |  | SOLE |  | 1600 | 0 | 0 |
| IMMUNEERING CORP - CLASS A | Common Stock | 45254E107 |  | 102135 | 15522 | SH |  | SOLE |  | 15522 | 0 | 0 |
| INCYTE CORP | Common Stock | 45337C102 |  | 3258521 | 32991 | SH |  | SOLE |  | 32991 | 0 | 0 |
| INSMED INC | Common Stock | 457669307 |  | 7377208 | 42388 | SH |  | SOLE |  | 42388 | 0 | 0 |
| IONIS PHARMACEUTICALS INC | Common Stock | 462222100 |  | 3353789 | 42394 | SH |  | SOLE |  | 42394 | 0 | 0 |
| DISC MEDICINE INC | Common Stock | 254604101 |  | 615507 | 7751 | SH |  | SOLE |  | 7751 | 0 | 0 |
| IRHYTHM HOLDINGS INC | Common Stock | 450056106 |  | 35488 | 200 | SH |  | SOLE |  | 200 | 0 | 0 |
| INTUITIVE SURGICAL INC | Common Stock | 46120E602 |  | 6919220 | 12217 | SH |  | SOLE |  | 12217 | 0 | 0 |
| JOHNSON  JOHNSON | Common Stock | 478160104 |  | 4610639 | 22279 | SH |  | SOLE |  | 22279 | 0 | 0 |
| KESTRA MEDICAL TECHNOLOGIES | Common Stock | G52441105 |  | 13260 | 500 | SH |  | SOLE |  | 500 | 0 | 0 |
| KYMERA THERAPEUTICS INC | Common Stock | 501575104 |  | 1908212 | 24524 | SH |  | SOLE |  | 24524 | 0 | 0 |
| ELI LILLY  CO | Common Stock | 532457108 |  | 6553399 | 6098 | SH |  | SOLE |  | 6098 | 0 | 0 |
| MAZE THERAPEUTICS INC | Common Stock | 578784100 |  | 474001 | 11441 | SH |  | SOLE |  | 11441 | 0 | 0 |
| MBX BIOSCIENCES INC | Common Stock | 55287L101 |  | 483098 | 15317 | SH |  | SOLE |  | 15317 | 0 | 0 |
| MCKESSON CORP | Common Stock | 58155Q103 |  | 1313645 | 1600 | SH |  | SOLE |  | 1600 | 0 | 0 |
| MEDTRONIC PLC | Common Stock | G5960L103 |  | 482963 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| MERCK  CO. INC. | Common Stock | 58933Y105 |  | 1222855 | 11512 | SH |  | SOLE |  | 11512 | 0 | 0 |
| NEWAMSTERDAM PHARMA CO NV | Common Stock | N62509109 |  | 928813 | 26477 | SH |  | SOLE |  | 26477 | 0 | 0 |
| NATERA INC | Common Stock | 632307104 |  | 366544 | 1600 | SH |  | SOLE |  | 1600 | 0 | 0 |
| OCULIS HOLDING AG | Common Stock | H5870P102 |  | 39940 | 2000 | SH |  | SOLE |  | 2000 | 0 | 0 |
| OCULAR THERAPEUTIX INC | Common Stock | 67576A100 |  | 433592 | 35716 | SH |  | SOLE |  | 35716 | 0 | 0 |
| OLEMA PHARMACEUTICALS INC | Common Stock | 68062P106 |  | 325450 | 13018 | SH |  | SOLE |  | 13018 | 0 | 0 |
| OMEROS CORP | Common Stock | 682143102 |  | 284298 | 16553 | SH |  | SOLE |  | 16553 | 0 | 0 |
| INSULET CORP | Common Stock | 45784P101 |  | 170544 | 600 | SH |  | SOLE |  | 600 | 0 | 0 |
| PRAXIS PRECISION MEDICINES I | Common Stock | 74006W207 |  | 1436858 | 4875 | SH |  | SOLE |  | 4875 | 0 | 0 |
| PROCEPT BIOROBOTICS CORP | Common Stock | 74276L105 |  | 157300 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| PTC THERAPEUTICS INC | Common Stock | 69366J200 |  | 1001381 | 13183 | SH |  | SOLE |  | 13183 | 0 | 0 |
| PROTAGONIST THERAPEUTICS INC | Common Stock | 74366E102 |  | 1204157 | 13787 | SH |  | SOLE |  | 13787 | 0 | 0 |
| PALVELLA THERAPEUTICS INC | Common Stock | 697947109 |  | 167472 | 1600 | SH |  | SOLE |  | 1600 | 0 | 0 |
| RAPPORT THERAPEUTICS INC | Common Stock | 75383L102 |  | 326640 | 10766 | SH |  | SOLE |  | 10766 | 0 | 0 |
| AVITA MEDICAL INC | Common Stock | 05380C102 |  | 17250 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| REPLIGEN CORP | Common Stock | 759916109 |  | 589896 | 3600 | SH |  | SOLE |  | 3600 | 0 | 0 |
| RESMED INC | Common Stock | 761152107 |  | 240870 | 1000 | SH |  | SOLE |  | 1000 | 0 | 0 |
| ROIVANT SCIENCES LTD | Common Stock | G76279101 |  | 2806461 | 129330 | SH |  | SOLE |  | 129330 | 0 | 0 |
| ROYALTY PHARMA PLC- CL A | Common Stock | G7709Q104 |  | 3076517 | 79620 | SH |  | SOLE |  | 79620 | 0 | 0 |
| REVOLUTION MEDICINES INC | Common Stock | 76155X100 |  | 2708180 | 34001 | SH |  | SOLE |  | 34001 | 0 | 0 |
| SEPTERNA INC | Common Stock | 81734D104 |  | 287052 | 10296 | SH |  | SOLE |  | 10296 | 0 | 0 |
| SIONNA THERAPEUTICS INC | Common Stock | 829401108 |  | 422590 | 10272 | SH |  | SOLE |  | 10272 | 0 | 0 |
| SCHOLAR ROCK HOLDING CORP | Common Stock | 80706P103 |  | 952449 | 21622 | SH |  | SOLE |  | 21622 | 0 | 0 |
| SURROZEN INC | Common Stock | 86889P208 |  | 33900 | 1500 | SH |  | SOLE |  | 1500 | 0 | 0 |
| STOKE THERAPEUTICS INC | Common Stock | 86150R107 |  | 409668 | 12907 | SH |  | SOLE |  | 12907 | 0 | 0 |
| SUPERNUS PHARMACEUTICALS INC | Common Stock | 868459108 |  | 613447 | 12343 | SH |  | SOLE |  | 12343 | 0 | 0 |
| STRYKER CORP | Common Stock | 863667101 |  | 1268143 | 3600 | SH |  | SOLE |  | 3600 | 0 | 0 |
| TECTONIC THERAPEUTIC INC | Common Stock | 878972108 |  | 126203 | 6050 | SH |  | SOLE |  | 6050 | 0 | 0 |
| TERNS PHARMACEUTICALS INC | Common Stock | 880881107 |  | 601071 | 14878 | SH |  | SOLE |  | 14878 | 0 | 0 |
| TENET HEALTHCARE CORP | Common Stock | 88033G407 |  | 1589760 | 8000 | SH |  | SOLE |  | 8000 | 0 | 0 |
| TRANSMEDICS GROUP INC | Common Stock | 89377M109 |  | 121650 | 1000 | SH |  | SOLE |  | 1000 | 0 | 0 |
| THERMO FISHER SCIENTIFIC INC | Common Stock | 883556102 |  | 2310883 | 3985 | SH |  | SOLE |  | 3985 | 0 | 0 |
| TANDEM DIABETES CARE INC | Common Stock | 875372203 |  | 175840 | 8000 | SH |  | SOLE |  | 8000 | 0 | 0 |
| TRAVERE THERAPEUTICS INC | Common Stock | 89422G107 |  | 576169 | 15079 | SH |  | SOLE |  | 15079 | 0 | 0 |
| UNITEDHEALTH GROUP INC | Common Stock | 91324P102 |  | 1307566 | 3961 | SH |  | SOLE |  | 3961 | 0 | 0 |
| UNITED THERAPEUTICS CORP | Common Stock | 91307C102 |  | 3662171 | 7516 | SH |  | SOLE |  | 7516 | 0 | 0 |
| VENTYX BIOSCIENCES INC | Common Stock | 92332V107 |  | 195301 | 21628 | SH |  | SOLE |  | 21628 | 0 | 0 |
| WAVE LIFE SCIENCES LTD | Common Stock | Y95308105 |  | 675614 | 39742 | SH |  | SOLE |  | 39742 | 0 | 0 |
| ZENAS BIOPHARMA INC | Common Stock | 98937L105 |  | 483431 | 13314 | SH |  | SOLE |  | 13314 | 0 | 0 |
| ZOETIS INC | Common Stock | 98978V103 |  | 251640 | 2000 | SH |  | SOLE |  | 2000 | 0 | 0 |
| ABIVAX SA-ADR | ADR | 00370M103 |  | 1566880 | 11619 | SH |  | SOLE |  | 11619 | 0 | 0 |
| ASTRAZENECA PLC-SPONS ADR | ADR | 046353108 |  | 12469017 | 135636 | SH |  | SOLE |  | 135636 | 0 | 0 |
| BELITE BIO INC - ADR | ADR | 07782B104 |  | 79980 | 500 | SH |  | SOLE |  | 500 | 0 | 0 |
| BIONTECH SE-ADR | ADR | 09075V102 |  | 1720740 | 18075 | SH |  | SOLE |  | 18075 | 0 | 0 |
| IMMUNOCORE HOLDINGS PLC-ADR | ADR | 45258D105 |  | 524433 | 15109 | SH |  | SOLE |  | 15109 | 0 | 0 |
| NOVO-NORDISK A/S-SPONS ADR | ADR | 670100205 |  | 508800 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| NOVARTIS AG-SPONSORED ADR | ADR | 66987V109 |  | 4963320 | 36000 | SH |  | SOLE |  | 36000 | 0 | 0 |
| SILENCE THERAPEUTICS PLC-ADR | ADR | 82686Q101 |  | 83010 | 13653 | SH |  | SOLE |  | 13653 | 0 | 0 |
| SANOFI-ADR | ADR | 80105N105 |  | 2671115 | 55120 | SH |  | SOLE |  | 55120 | 0 | 0 |
| TAKEDA PHARMACEUTIC-SP ADR | ADR | 874060205 |  | 997760 | 64000 | SH |  | SOLE |  | 64000 | 0 | 0 |
| VALNEVA SE - ADR | ADR | 92025Y103 |  | 44100 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| SS SPDR S BIOTECH ETF | ETP | 78464A870 |  | 74133 | 608 | SH |  | SOLE |  | 608 | 0 | 0 |
| GSK PLC-SPON ADR | ADR | 37733W204 |  | 4424 | 0 | SH |  | SOLE |  | 0 | 0 | 0 |
| AMER SPORTS INC | Common Stock | G0260P102 |  | 430907 | 11537 | SH |  | SOLE |  | 11537 | 0 | 0 |
| CHIPOTLE MEXICAN GRILL INC | Common Stock | 169656105 |  | 2257 | 61 | SH |  | SOLE |  | 61 | 0 | 0 |
| COSTCO WHOLESALE CORP | Common Stock | 22160K105 |  | 12865250 | 14919 | SH |  | SOLE |  | 14919 | 0 | 0 |
| DECKERS OUTDOOR CORP | Common Stock | 243537107 |  | 405142 | 3908 | SH |  | SOLE |  | 3908 | 0 | 0 |
| ALPHABET INC-CL C | Common Stock | 02079K107 |  | 23210531 | 73966 | SH |  | SOLE |  | 73966 | 0 | 0 |
| HOME DEPOT INC | Common Stock | 437076102 |  | 4776452 | 13881 | SH |  | SOLE |  | 13881 | 0 | 0 |
| HILTON WORLDWIDE HOLDINGS IN | Common Stock | 43300A203 |  | 293282 | 1021 | SH |  | SOLE |  | 1021 | 0 | 0 |
| HERSHEY CO/THE | Common Stock | 427866108 |  | 1820 | 10 | SH |  | SOLE |  | 10 | 0 | 0 |
| LOWE'S COS INC | Common Stock | 548661107 |  | 1355319 | 5620 | SH |  | SOLE |  | 5620 | 0 | 0 |
| NIKE INC -CL B | Common Stock | 654106103 |  | 2509713 | 39203 | SH |  | SOLE |  | 39203 | 0 | 0 |
| PROCTER  GAMBLE CO/THE | Common Stock | 742718109 |  | 980670 | 6843 | SH |  | SOLE |  | 6843 | 0 | 0 |
| FERRARI NV | Common Stock | N3167Y103 |  | 3136456 | 8487 | SH |  | SOLE |  | 8487 | 0 | 0 |
| STARBUCKS CORP | Common Stock | 855244109 |  | 2717794 | 32274 | SH |  | SOLE |  | 32274 | 0 | 0 |
| VF CORP | Common Stock | 918204108 |  | 450300 | 24906 | SH |  | SOLE |  | 24906 | 0 | 0 |
| BRITISH AMERICAN TOB-SP ADR | ADR | 110448107 |  | 3537787 | 61857 | SH |  | SOLE |  | 61857 | 0 | 0 |
| DIAGEO PLC-SPONSORED ADR | ADR | 25243Q205 |  | 162533 | 1884 | SH |  | SOLE |  | 1884 | 0 | 0 |
| H WORLD GROUP LTD-ADR | ADR | 44332N106 |  | 301026 | 6398 | SH |  | SOLE |  | 6398 | 0 | 0 |
| ATRENEW INC | ADR | 00138L108 |  | 1957290 | 369300 | SH |  | SOLE |  | 369300 | 0 | 0 |
| SS CONSUMER DISC SELECT SECT | ETP | 81369Y407 |  | 720042 | 6030 | SH |  | SOLE |  | 6030 | 0 | 0 |
| AUTOLIV INC | Common Stock | 052800109 |  | 237400 | 2000 | SH |  | SOLE |  | 2000 | 0 | 0 |
| AUTOZONE INC | Common Stock | 053332102 |  | 339150 | 100 | SH |  | SOLE |  | 100 | 0 | 0 |
| CANADIAN SOLAR INC | Common Stock | 136635109 |  | 47540 | 2000 | SH |  | SOLE |  | 2000 | 0 | 0 |
| CHINA YUCHAI INTL LTD | Common Stock | G21082105 |  | 71000 | 2000 | SH |  | SOLE |  | 2000 | 0 | 0 |
| ON SEMICONDUCTOR | Common Stock | 682189105 |  | 135375 | 2500 | SH |  | SOLE |  | 2500 | 0 | 0 |
| QUALCOMM INC | Common Stock | 747525103 |  | 5526283 | 32308 | SH |  | SOLE |  | 32308 | 0 | 0 |
| TESLA INC | Common Stock | 88160R101 |  | 24516036 | 54514 | SH |  | SOLE |  | 54514 | 0 | 0 |
| HESAI GROUP | ADR | 428050108 |  | 448000 | 20000 | SH |  | SOLE |  | 20000 | 0 | 0 |
| LI AUTO INC - ADR | ADR | 50202M102 |  | 169300 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| NIO INC - ADR | ADR | 62914V106 |  | 382500 | 75000 | SH |  | SOLE |  | 75000 | 0 | 0 |
| UXIN LTD - ADR | ADR | 91818X306 |  | 33700 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| WERIDE INC-ADR | ADR | 950915108 |  | 347200 | 40000 | SH |  | SOLE |  | 40000 | 0 | 0 |
| XPENG INC - ADR | ADR | 98422D105 |  | 202800 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| ABBOTT LABORATORIES | Common Stock | 002824100 |  | 568566 | 4538 | SH |  | SOLE |  | 4538 | 0 | 0 |
| AMERICAN EXPRESS CO | Common Stock | 025816109 |  | 536797 | 1451 | SH |  | SOLE |  | 1451 | 0 | 0 |
| BANK OF AMERICA CORP | Common Stock | 060505104 |  | 1009030 | 18346 | SH |  | SOLE |  | 18346 | 0 | 0 |
| BERKSHIRE HATHAWAY INC-CL B | Common Stock | 084670702 |  | 1806524 | 3594 | SH |  | SOLE |  | 3594 | 0 | 0 |
| CATERPILLAR INC | Common Stock | 149123101 |  | 699474 | 1221 | SH |  | SOLE |  | 1221 | 0 | 0 |
| SALESFORCE INC | Common Stock | 79466L302 |  | 658436 | 2482 | SH |  | SOLE |  | 2482 | 0 | 0 |
| CISCO SYSTEMS INC | Common Stock | 17275R102 |  | 9406750 | 122118 | SH |  | SOLE |  | 122118 | 0 | 0 |
| CHEVRON CORP | Common Stock | 166764100 |  | 766013 | 5026 | SH |  | SOLE |  | 5026 | 0 | 0 |
| WALT DISNEY CO/THE | Common Stock | 254687106 |  | 536518 | 4688 | SH |  | SOLE |  | 4688 | 0 | 0 |
| GENERAL ELECTRIC | Common Stock | 369604301 |  | 852599 | 2765 | SH |  | SOLE |  | 2765 | 0 | 0 |
| GOLDMAN SACHS GROUP INC | Common Stock | 38141G104 |  | 693531 | 789 | SH |  | SOLE |  | 789 | 0 | 0 |
| INTL BUSINESS MACHINES CORP | Common Stock | 459200101 |  | 719494 | 2429 | SH |  | SOLE |  | 2429 | 0 | 0 |
| JPMORGAN CHASE  CO | Common Stock | 46625H100 |  | 2309995 | 7169 | SH |  | SOLE |  | 7169 | 0 | 0 |
| COCA-COLA CO/THE | Common Stock | 191216100 |  | 745241 | 10660 | SH |  | SOLE |  | 10660 | 0 | 0 |
| LINDE PLC | Common Stock | G54950103 |  | 6155792 | 14437 | SH |  | SOLE |  | 14437 | 0 | 0 |
| MCDONALD'S CORP | Common Stock | 580135101 |  | 568777 | 1861 | SH |  | SOLE |  | 1861 | 0 | 0 |
| PEPSICO INC | Common Stock | 713448108 |  | 6116631 | 42259 | SH |  | SOLE |  | 42259 | 0 | 0 |
| PHILIP MORRIS INTERNATIONAL | Common Stock | 718172109 |  | 656272 | 4058 | SH |  | SOLE |  | 4058 | 0 | 0 |
| RTX CORP | Common Stock | 75513E101 |  | 640066 | 3490 | SH |  | SOLE |  | 3490 | 0 | 0 |
| WELLS FARGO  CO | Common Stock | 949746101 |  | 778406 | 8352 | SH |  | SOLE |  | 8352 | 0 | 0 |
| WALMART INC | Common Stock | 931142103 |  | 1276169 | 11433 | SH |  | SOLE |  | 11433 | 0 | 0 |
| EXXON MOBIL CORP | Common Stock | 30231G102 |  | 1337699 | 11116 | SH |  | SOLE |  | 11116 | 0 | 0 |
| AIRBNB INC-CLASS A | Common Stock | 009066101 |  | 1633390 | 12035 | SH |  | SOLE |  | 12035 | 0 | 0 |
| ADOBE INC | Common Stock | 00724F101 |  | 4145982 | 11846 | SH |  | SOLE |  | 11846 | 0 | 0 |
| AUTOMATIC DATA PROCESSING | Common Stock | 053015103 |  | 2960635 | 11445 | SH |  | SOLE |  | 11445 | 0 | 0 |
| AMERICAN ELECTRIC POWER | Common Stock | 025537101 |  | 1742795 | 15114 | SH |  | SOLE |  | 15114 | 0 | 0 |
| ALNYLAM PHARMACEUTICALS INC | Common Stock | 02043Q107 |  | 10047423 | 25267 | SH |  | SOLE |  | 25267 | 0 | 0 |
| APPLIED MATERIALS INC | Common Stock | 038222105 |  | 5793583 | 22544 | SH |  | SOLE |  | 22544 | 0 | 0 |
| AXON ENTERPRISE INC | Common Stock | 05464C101 |  | 1268188 | 2233 | SH |  | SOLE |  | 2233 | 0 | 0 |
| BAKER HUGHES CO | Common Stock | 05722G100 |  | 1271659 | 27924 | SH |  | SOLE |  | 27924 | 0 | 0 |
| COCA-COLA EUROPACIFIC PARTNE | Common Stock | G25839104 |  | 1176016 | 12966 | SH |  | SOLE |  | 12966 | 0 | 0 |
| CONSTELLATION ENERGY | Common Stock | 21037T109 |  | 3121847 | 8837 | SH |  | SOLE |  | 8837 | 0 | 0 |
| CHARTER COMMUNICATIONS INC-A | Common Stock | 16119P108 |  | 764443 | 3662 | SH |  | SOLE |  | 3662 | 0 | 0 |
| COMCAST CORP-CLASS A | Common Stock | 20030N101 |  | 3074187 | 102850 | SH |  | SOLE |  | 102850 | 0 | 0 |
| COPART INC | Common Stock | 217204106 |  | 1072475 | 27394 | SH |  | SOLE |  | 27394 | 0 | 0 |
| COSTAR GROUP INC | Common Stock | 22160N109 |  | 806477 | 11994 | SH |  | SOLE |  | 11994 | 0 | 0 |
| CSX CORP | Common Stock | 126408103 |  | 1910230 | 52696 | SH |  | SOLE |  | 52696 | 0 | 0 |
| CINTAS CORP | Common Stock | 172908105 |  | 2138732 | 11372 | SH |  | SOLE |  | 11372 | 0 | 0 |
| COGNIZANT TECH SOLUTIONS-A | Common Stock | 192446102 |  | 1133614 | 13658 | SH |  | SOLE |  | 13658 | 0 | 0 |
| ELECTRONIC ARTS INC | Common Stock | 285512109 |  | 1446248 | 7078 | SH |  | SOLE |  | 7078 | 0 | 0 |
| EXELON CORP | Common Stock | 30161N101 |  | 1246238 | 28590 | SH |  | SOLE |  | 28590 | 0 | 0 |
| DIAMONDBACK ENERGY INC | Common Stock | 25278X109 |  | 1218876 | 8108 | SH |  | SOLE |  | 8108 | 0 | 0 |
| FASTENAL CO | Common Stock | 311900104 |  | 1303743 | 32488 | SH |  | SOLE |  | 32488 | 0 | 0 |
| FERROVIAL SE | Common Stock | N3168P101 |  | 1341562 | 20764 | SH |  | SOLE |  | 20764 | 0 | 0 |
| FORTINET INC | Common Stock | 34959E109 |  | 1671104 | 21044 | SH |  | SOLE |  | 21044 | 0 | 0 |
| GE HEALTHCARE TECHNOLOGY | Common Stock | 36266G107 |  | 1057320 | 12891 | SH |  | SOLE |  | 12891 | 0 | 0 |
| GILEAD SCIENCES INC | Common Stock | 375558103 |  | 21593403 | 175928 | SH |  | SOLE |  | 175928 | 0 | 0 |
| HONEYWELL INTERNATIONAL INC | Common Stock | 438516106 |  | 3504987 | 17966 | SH |  | SOLE |  | 17966 | 0 | 0 |
| IDEXX LABORATORIES INC | Common Stock | 45168D104 |  | 1528958 | 2260 | SH |  | SOLE |  | 2260 | 0 | 0 |
| KEURIG DR PEPPER INC | Common Stock | 49271V100 |  | 1076872 | 38446 | SH |  | SOLE |  | 38446 | 0 | 0 |
| KRAFT HEINZ CO/THE | Common Stock | 500754106 |  | 812278 | 33496 | SH |  | SOLE |  | 33496 | 0 | 0 |
| MARRIOTT INTERNATIONAL -CL A | Common Stock | 571903202 |  | 2355963 | 7594 | SH |  | SOLE |  | 7594 | 0 | 0 |
| MICROCHIP TECHNOLOGY INC | Common Stock | 595017104 |  | 974534 | 15294 | SH |  | SOLE |  | 15294 | 0 | 0 |
| MONDELEZ INTERNATIONAL INC-A | Common Stock | 609207105 |  | 1982034 | 36515 | SH |  | SOLE |  | 36515 | 0 | 0 |
| MONSTER BEVERAGE CORP | Common Stock | 61174X109 |  | 2119772 | 27648 | SH |  | SOLE |  | 27648 | 0 | 0 |
| MONOLITHIC POWER SYSTEMS INC | Common Stock | 609839105 |  | 1230928 | 1356 | SH |  | SOLE |  | 1356 | 0 | 0 |
| MARVELL TECHNOLOGY INC | Common Stock | 573874104 |  | 2073172 | 24396 | SH |  | SOLE |  | 24396 | 0 | 0 |
| STRATEGY INC | Common Stock | 594972408 |  | 1151173 | 7576 | SH |  | SOLE |  | 7576 | 0 | 0 |
| NXP SEMICONDUCTORS NV | Common Stock | N6596X109 |  | 1551735 | 7122 | SH |  | SOLE |  | 7122 | 0 | 0 |
| OLD DOMINION FREIGHT LINE | Common Stock | 679580100 |  | 927786 | 5917 | SH |  | SOLE |  | 5917 | 0 | 0 |
| O'REILLY AUTOMOTIVE INC | Common Stock | 67103H107 |  | 2178733 | 23887 | SH |  | SOLE |  | 23887 | 0 | 0 |
| PAYCHEX INC | Common Stock | 704326107 |  | 1142553 | 10185 | SH |  | SOLE |  | 10185 | 0 | 0 |
| PACCAR INC | Common Stock | 693718108 |  | 1645421 | 14863 | SH |  | SOLE |  | 14863 | 0 | 0 |
| PAYPAL HOLDINGS INC | Common Stock | 70450Y103 |  | 1545786 | 26478 | SH |  | SOLE |  | 26478 | 0 | 0 |
| REGENERON PHARMACEUTICALS | Common Stock | 75886F107 |  | 15246748 | 19753 | SH |  | SOLE |  | 19753 | 0 | 0 |
| ROPER TECHNOLOGIES INC | Common Stock | 776696106 |  | 1355866 | 3046 | SH |  | SOLE |  | 3046 | 0 | 0 |
| ROSS STORES INC | Common Stock | 778296103 |  | 1657828 | 9203 | SH |  | SOLE |  | 9203 | 0 | 0 |
| SEAGATE TECHNOLOGY HOLDINGS | Common Stock | G7997R103 |  | 1667536 | 6043 | SH |  | SOLE |  | 6043 | 0 | 0 |
| T-MOBILE US INC | Common Stock | 872590104 |  | 6426622 | 31652 | SH |  | SOLE |  | 31652 | 0 | 0 |
| THOMSON REUTERS CORP | Common Stock | 884903808 |  | 1660231 | 12588 | SH |  | SOLE |  | 12588 | 0 | 0 |
| TAKE-TWO INTERACTIVE SOFTWRE | Common Stock | 874054109 |  | 1338781 | 5229 | SH |  | SOLE |  | 5229 | 0 | 0 |
| TEXAS INSTRUMENTS INC | Common Stock | 882508104 |  | 4460948 | 25713 | SH |  | SOLE |  | 25713 | 0 | 0 |
| VERISK ANALYTICS INC | Common Stock | 92345Y106 |  | 882233 | 3944 | SH |  | SOLE |  | 3944 | 0 | 0 |
| VERTEX PHARMACEUTICALS INC | Common Stock | 92532F100 |  | 21782588 | 48047 | SH |  | SOLE |  | 48047 | 0 | 0 |
| WARNER BROS DISCOVERY INC | Common Stock | 934423104 |  | 2020945 | 70123 | SH |  | SOLE |  | 70123 | 0 | 0 |
| XCEL ENERGY INC | Common Stock | 98389B100 |  | 1245004 | 16740 | SH |  | SOLE |  | 16740 | 0 | 0 |
| ARM HOLDINGS PLC-ADR | ADR | 042068205 |  | 427949 | 3915 | SH |  | SOLE |  | 3915 | 0 | 0 |
| GOLDMAN SACHS PHYSICAL GOLD | ETP | 38150K103 |  | 10084350 | 237000 | SH |  | SOLE |  | 237000 | 0 | 0 |
| GRANITESHARES GOLD TRUST | ETP | 38748G101 |  | 12874470 | 303000 | SH |  | SOLE |  | 303000 | 0 | 0 |
| SPDR GOLD SHARES | ETP | 78463V107 |  | 12959337 | 32700 | SH |  | SOLE |  | 32700 | 0 | 0 |
| SPDR GOLD MINISHARES TRUST | ETP | 98149E303 |  | 17603294 | 206200 | SH |  | SOLE |  | 206200 | 0 | 0 |
| ISHARES GOLD TRUST | ETP | 464285204 |  | 6250090 | 77000 | SH |  | SOLE |  | 77000 | 0 | 0 |
| ISHARES GOLD TRUST MICRO | ETP | 46436F103 |  | 16744605 | 389500 | SH |  | SOLE |  | 389500 | 0 | 0 |
| ABRDN PHYSICAL GOLD SHARES | ETP | 00326A104 |  | 8359780 | 203500 | SH |  | SOLE |  | 203500 | 0 | 0 |
| ABRDN PHYSICAL SILVER SHARES | ETP | 003264108 |  | 202920 | 3000 | SH |  | SOLE |  | 3000 | 0 | 0 |
| ISHARES SILVER TRUST | ETP | 46428Q109 |  | 1481660 | 23000 | SH |  | SOLE |  | 23000 | 0 | 0 |
| PROSHARES ULTRA GOLD | ETP | 74347W601 |  | 21475136 | 386800 | SH |  | SOLE |  | 386800 | 0 | 0 |
| SPDR DJIA TRUST | ETP | 78467X109 |  | 1 | 0 | SH |  | SOLE |  | 0 | 0 | 0 |
| INVESCO QQQ TRUST SERIES 1 | ETP | 46090E103 |  | 30 | 0 | SH |  | SOLE |  | 0 | 0 | 0 |
| SPDR S 500 ETF TRUST | ETP | 78462F103 |  | 2 | 0 | SH |  | SOLE |  | 0 | 0 | 0 |
| AARDVARK THERAPEUTICS INC | Common Stock | 002942100 |  | 46568 | 3548 | SH |  | SOLE |  | 3548 | 0 | 0 |
| ABCELLERA BIOLOGICS INC | Common Stock | 00288U106 |  | 166817 | 48777 | SH |  | SOLE |  | 48777 | 0 | 0 |
| ARBUTUS BIOPHARMA CORP | Common Stock | 03879J100 |  | 150741 | 31339 | SH |  | SOLE |  | 31339 | 0 | 0 |
| ACADIA PHARMACEUTICALS INC | Common Stock | 004225108 |  | 736341 | 27568 | SH |  | SOLE |  | 27568 | 0 | 0 |
| AC IMMUNE SA | Common Stock | H00263105 |  | 51377 | 16362 | SH |  | SOLE |  | 16362 | 0 | 0 |
| ARCELLX INC | Common Stock | 03940C100 |  | 614314 | 9422 | SH |  | SOLE |  | 9422 | 0 | 0 |
| ACLARIS THERAPEUTICS INC | Common Stock | 00461U105 |  | 53142 | 17655 | SH |  | SOLE |  | 17655 | 0 | 0 |
| ADMA BIOLOGICS INC | Common Stock | 000899104 |  | 707384 | 38782 | SH |  | SOLE |  | 38782 | 0 | 0 |
| AGIOS PHARMACEUTICALS INC | Common Stock | 00847X104 |  | 258644 | 9502 | SH |  | SOLE |  | 9502 | 0 | 0 |
| ALKERMES PLC | Common Stock | G01767105 |  | 752830 | 26906 | SH |  | SOLE |  | 26906 | 0 | 0 |
| ALLOGENE THERAPEUTICS INC | Common Stock | 019770106 |  | 50169 | 36620 | SH |  | SOLE |  | 36620 | 0 | 0 |
| ALUMIS INC | Common Stock | 022307102 |  | 154598 | 15840 | SH |  | SOLE |  | 15840 | 0 | 0 |
| ALTIMMUNE INC | Common Stock | 02155H200 |  | 61381 | 17003 | SH |  | SOLE |  | 17003 | 0 | 0 |
| ALVOTECH SA | Common Stock | L01800108 |  | 261661 | 51006 | SH |  | SOLE |  | 51006 | 0 | 0 |
| AMYLYX PHARMACEUTICALS INC | Common Stock | 03237H101 |  | 216172 | 17895 | SH |  | SOLE |  | 17895 | 0 | 0 |
| AMPHASTAR PHARMACEUTICALS IN | Common Stock | 03209R103 |  | 200529 | 7488 | SH |  | SOLE |  | 7488 | 0 | 0 |
| AMNEAL PHARMACEUTICALS INC | Common Stock | 03168L105 |  | 645435 | 51225 | SH |  | SOLE |  | 51225 | 0 | 0 |
| ANI PHARMACEUTICALS INC | Common Stock | 00182C103 |  | 288920 | 3660 | SH |  | SOLE |  | 3660 | 0 | 0 |
| APOGEE THERAPEUTICS INC | Common Stock | 03770N101 |  | 674414 | 8935 | SH |  | SOLE |  | 8935 | 0 | 0 |
| APELLIS PHARMACEUTICALS INC | Common Stock | 03753U106 |  | 517899 | 20617 | SH |  | SOLE |  | 20617 | 0 | 0 |
| AQUESTIVE THERAPEUTICS INC | Common Stock | 03843E104 |  | 128425 | 19880 | SH |  | SOLE |  | 19880 | 0 | 0 |
| ARCTURUS THERAPEUTICS HOLDIN | Common Stock | 03969T109 |  | 28382 | 4630 | SH |  | SOLE |  | 4630 | 0 | 0 |
| ARDELYX INC | Common Stock | 039697107 |  | 230827 | 39593 | SH |  | SOLE |  | 39593 | 0 | 0 |
| ARCUTIS BIOTHERAPEUTICS INC | Common Stock | 03969K108 |  | 579638 | 19960 | SH |  | SOLE |  | 19960 | 0 | 0 |
| ARVINAS INC | Common Stock | 04335A105 |  | 124115 | 10465 | SH |  | SOLE |  | 10465 | 0 | 0 |
| AURINIA PHARMACEUTICALS INC | Common Stock | 05156V102 |  | 342654 | 21483 | SH |  | SOLE |  | 21483 | 0 | 0 |
| AURA BIOSCIENCES INC | Common Stock | 05153U107 |  | 56397 | 10348 | SH |  | SOLE |  | 10348 | 0 | 0 |
| ARRIVENT BIOPHARMA INC | Common Stock | 04272N102 |  | 135347 | 6727 | SH |  | SOLE |  | 6727 | 0 | 0 |
| ATEA PHARMACEUTICALS INC | Common Stock | 04683R106 |  | 45450 | 12731 | SH |  | SOLE |  | 12731 | 0 | 0 |
| ANAVEX LIFE SCIENCES CORP | Common Stock | 032797300 |  | 51830 | 14559 | SH |  | SOLE |  | 14559 | 0 | 0 |
| AXSOME THERAPEUTICS INC | Common Stock | 05464T104 |  | 1500388 | 8215 | SH |  | SOLE |  | 8215 | 0 | 0 |
| BRIDGEBIO PHARMA INC | Common Stock | 10806X102 |  | 2401939 | 31402 | SH |  | SOLE |  | 31402 | 0 | 0 |
| BICARA THERAPEUTICS INC | Common Stock | 055477103 |  | 150241 | 8927 | SH |  | SOLE |  | 8927 | 0 | 0 |
| BIOCRYST PHARMACEUTICALS INC | Common Stock | 09058V103 |  | 267602 | 34308 | SH |  | SOLE |  | 34308 | 0 | 0 |
| BLACK DIAMOND THERAPEUTICS I | Common Stock | 09203E105 |  | 22560 | 9284 | SH |  | SOLE |  | 9284 | 0 | 0 |
| BEAM THERAPEUTICS INC | Common Stock | 07373V105 |  | 458350 | 16535 | SH |  | SOLE |  | 16535 | 0 | 0 |
| BIOGEN INC | Common Stock | 09062X103 |  | 4207041 | 23905 | SH |  | SOLE |  | 23905 | 0 | 0 |
| BIOAGE LABS INC | Common Stock | 09077V100 |  | 77303 | 5843 | SH |  | SOLE |  | 5843 | 0 | 0 |
| BIOMARIN PHARMACEUTICAL INC | Common Stock | 09061G101 |  | 1860456 | 31305 | SH |  | SOLE |  | 31305 | 0 | 0 |
| CABALETTA BIO INC | Common Stock | 12674W109 |  | 34352 | 15686 | SH |  | SOLE |  | 15686 | 0 | 0 |
| CANDEL THERAPEUTICS INC | Common Stock | 137404109 |  | 50545 | 8946 | SH |  | SOLE |  | 8946 | 0 | 0 |
| CARIS LIFE SCIENCES INC | Common Stock | 142152107 |  | 1240432 | 45976 | SH |  | SOLE |  | 45976 | 0 | 0 |
| C4 THERAPEUTICS INC | Common Stock | 12529R107 |  | 30163 | 15792 | SH |  | SOLE |  | 15792 | 0 | 0 |
| CODEXIS INC | Common Stock | 192005106 |  | 23990 | 14718 | SH |  | SOLE |  | 14718 | 0 | 0 |
| CULLINAN THERAPEUTICS INC | Common Stock | 230031106 |  | 99629 | 9626 | SH |  | SOLE |  | 9626 | 0 | 0 |
| CG ONCOLOGY INC | Common Stock | 156944100 |  | 545780 | 13145 | SH |  | SOLE |  | 13145 | 0 | 0 |
| COHERUS ONCOLOGY INC | Common Stock | 19249H103 |  | 27968 | 19696 | SH |  | SOLE |  | 19696 | 0 | 0 |
| COGENT BIOSCIENCES INC | Common Stock | 19240Q201 |  | 888497 | 25014 | SH |  | SOLE |  | 25014 | 0 | 0 |
| COLLEGIUM PHARMACEUTICAL INC | Common Stock | 19459J104 |  | 238491 | 5151 | SH |  | SOLE |  | 5151 | 0 | 0 |
| CARIBOU BIOSCIENCES INC | Common Stock | 142038108 |  | 24217 | 15231 | SH |  | SOLE |  | 15231 | 0 | 0 |
| CORMEDIX INC | Common Stock | 21900C308 |  | 149318 | 12839 | SH |  | SOLE |  | 12839 | 0 | 0 |
| CRINETICS PHARMACEUTICALS IN | Common Stock | 22663K107 |  | 719803 | 15463 | SH |  | SOLE |  | 15463 | 0 | 0 |
| CASTLE BIOSCIENCES INC | Common Stock | 14843C105 |  | 185008 | 4756 | SH |  | SOLE |  | 4756 | 0 | 0 |
| CYTOMX THERAPEUTICS INC | Common Stock | 23284F105 |  | 117614 | 27609 | SH |  | SOLE |  | 27609 | 0 | 0 |
| CONTINEUM THERAPEUTICS INC-A | Common Stock | 21217B100 |  | 43023 | 3764 | SH |  | SOLE |  | 3764 | 0 | 0 |
| CYTOKINETICS INC | Common Stock | 23282W605 |  | 1265907 | 19923 | SH |  | SOLE |  | 19923 | 0 | 0 |
| DAY ONE BIOPHARMACEUTICALS I | Common Stock | 23954D109 |  | 155933 | 16731 | SH |  | SOLE |  | 16731 | 0 | 0 |
| DENALI THERAPEUTICS INC | Common Stock | 24823R105 |  | 394556 | 23898 | SH |  | SOLE |  | 23898 | 0 | 0 |
| DYNAVAX TECHNOLOGIES CORP | Common Stock | 268158201 |  | 294281 | 19134 | SH |  | SOLE |  | 19134 | 0 | 0 |
| DYNE THERAPEUTICS INC | Common Stock | 26818M108 |  | 455220 | 23273 | SH |  | SOLE |  | 23273 | 0 | 0 |
| EDITAS MEDICINE INC | Common Stock | 28106W103 |  | 32609 | 15907 | SH |  | SOLE |  | 15907 | 0 | 0 |
| ENLIVEN THERAPEUTICS INC | Common Stock | 29337E102 |  | 148933 | 9671 | SH |  | SOLE |  | 9671 | 0 | 0 |
| ENANTA PHARMACEUTICALS INC | Common Stock | 29251M106 |  | 74166 | 4703 | SH |  | SOLE |  | 4703 | 0 | 0 |
| EVOLUS INC | Common Stock | 30052C107 |  | 70237 | 10562 | SH |  | SOLE |  | 10562 | 0 | 0 |
| ERASCA INC | Common Stock | 29479A108 |  | 171979 | 46231 | SH |  | SOLE |  | 46231 | 0 | 0 |
| ESPERION THERAPEUTICS INC | Common Stock | 29664W105 |  | 144134 | 38955 | SH |  | SOLE |  | 38955 | 0 | 0 |
| ETON PHARMACEUTICALS INC | Common Stock | 29772L108 |  | 73897 | 4370 | SH |  | SOLE |  | 4370 | 0 | 0 |
| EDGEWISE THERAPEUTICS INC | Common Stock | 28036F105 |  | 428084 | 17251 | SH |  | SOLE |  | 17251 | 0 | 0 |
| EXELIXIS INC | Common Stock | 30161Q104 |  | 1914889 | 43689 | SH |  | SOLE |  | 43689 | 0 | 0 |
| 4D MOLECULAR THERAPEUTICS IN | Common Stock | 35104E100 |  | 69825 | 9310 | SH |  | SOLE |  | 9310 | 0 | 0 |
| FOGHORN THERAPEUTICS INC | Common Stock | 344174107 |  | 49761 | 9215 | SH |  | SOLE |  | 9215 | 0 | 0 |
| AMICUS THERAPEUTICS INC | Common Stock | 03152W109 |  | 715916 | 50275 | SH |  | SOLE |  | 50275 | 0 | 0 |
| FORTREA HOLDINGS INC | Common Stock | 34965K107 |  | 259733 | 15057 | SH |  | SOLE |  | 15057 | 0 | 0 |
| FULCRUM THERAPEUTICS INC | Common Stock | 359616109 |  | 99743 | 8819 | SH |  | SOLE |  | 8819 | 0 | 0 |
| GERON CORP | Common Stock | 374163103 |  | 137306 | 104020 | SH |  | SOLE |  | 104020 | 0 | 0 |
| GUARDANT HEALTH INC | Common Stock | 40131M109 |  | 2153213 | 21081 | SH |  | SOLE |  | 21081 | 0 | 0 |
| GH RESEARCH PLC | Common Stock | G3855L106 |  | 128359 | 10107 | SH |  | SOLE |  | 10107 | 0 | 0 |
| HALOZYME THERAPEUTICS INC | Common Stock | 40637H109 |  | 1289603 | 19162 | SH |  | SOLE |  | 19162 | 0 | 0 |
| HARMONY BIOSCIENCES HOLDINGS | Common Stock | 413197104 |  | 351187 | 9385 | SH |  | SOLE |  | 9385 | 0 | 0 |
| HARROW INC | Common Stock | 415858109 |  | 295715 | 6035 | SH |  | SOLE |  | 6035 | 0 | 0 |
| HUMACYTE INC | Common Stock | 44486Q103 |  | 29311 | 30516 | SH |  | SOLE |  | 30516 | 0 | 0 |
| IMMUNITYBIO INC | Common Stock | 45256X103 |  | 317790 | 160500 | SH |  | SOLE |  | 160500 | 0 | 0 |
| IDEAYA BIOSCIENCES INC | Common Stock | 45166A102 |  | 493832 | 14285 | SH |  | SOLE |  | 14285 | 0 | 0 |
| IMMUNOVANT INC | Common Stock | 45258J102 |  | 726021 | 28561 | SH |  | SOLE |  | 28561 | 0 | 0 |
| INHIBRX BIOSCIENCES INC | Common Stock | 45720N103 |  | 187230 | 2370 | SH |  | SOLE |  | 2370 | 0 | 0 |
| INDIVIOR PLC | Common Stock | G4766E116 |  | 729979 | 20345 | SH |  | SOLE |  | 20345 | 0 | 0 |
| INNOVIVA INC | Common Stock | 45781M101 |  | 243558 | 12184 | SH |  | SOLE |  | 12184 | 0 | 0 |
| IOVANCE BIOTHERAPEUTICS INC | Common Stock | 462260100 |  | 176593 | 64686 | SH |  | SOLE |  | 64686 | 0 | 0 |
| IRONWOOD PHARMACEUTICALS INC | Common Stock | 46333X108 |  | 89332 | 26508 | SH |  | SOLE |  | 26508 | 0 | 0 |
| INVIVYD INC | Common Stock | 00534A102 |  | 111538 | 45157 | SH |  | SOLE |  | 45157 | 0 | 0 |
| JANUX THERAPEUTICS INC | Common Stock | 47103J105 |  | 135254 | 9801 | SH |  | SOLE |  | 9801 | 0 | 0 |
| JAZZ PHARMACEUTICALS PLC | Common Stock | G50871105 |  | 1683340 | 9902 | SH |  | SOLE |  | 9902 | 0 | 0 |
| KALVISTA PHARMACEUTICALS INC | Common Stock | 483497103 |  | 133011 | 8236 | SH |  | SOLE |  | 8236 | 0 | 0 |
| KAMADA LTD | Common Stock | M6240T109 |  | 66357 | 9399 | SH |  | SOLE |  | 9399 | 0 | 0 |
| KINIKSA PHARMACEUTICALS INTE | Common Stock | G52694109 |  | 303559 | 7359 | SH |  | SOLE |  | 7359 | 0 | 0 |
| KODIAK SCIENCES INC | Common Stock | 50015M109 |  | 241686 | 8644 | SH |  | SOLE |  | 8644 | 0 | 0 |
| KEROS THERAPEUTICS INC | Common Stock | 492327101 |  | 101067 | 4964 | SH |  | SOLE |  | 4964 | 0 | 0 |
| KRYSTAL BIOTECH INC | Common Stock | 501147102 |  | 1164902 | 4725 | SH |  | SOLE |  | 4725 | 0 | 0 |
| KURA ONCOLOGY INC | Common Stock | 50127T109 |  | 147320 | 14179 | SH |  | SOLE |  | 14179 | 0 | 0 |
| KYVERNA THERAPEUTICS INC | Common Stock | 501976104 |  | 67088 | 7137 | SH |  | SOLE |  | 7137 | 0 | 0 |
| LENZ THERAPEUTICS INC | Common Stock | 52635N103 |  | 81584 | 5099 | SH |  | SOLE |  | 5099 | 0 | 0 |
| LIFECORE BIOMEDICAL INC | Common Stock | 514766104 |  | 49939 | 6105 | SH |  | SOLE |  | 6105 | 0 | 0 |
| LIGAND PHARMACEUTICALS | Common Stock | 53220K504 |  | 606347 | 3207 | SH |  | SOLE |  | 3207 | 0 | 0 |
| LARIMAR THERAPEUTICS INC | Common Stock | 517125100 |  | 53138 | 13947 | SH |  | SOLE |  | 13947 | 0 | 0 |
| LEXEO THERAPEUTICS INC | Common Stock | 52886X107 |  | 118097 | 11893 | SH |  | SOLE |  | 11893 | 0 | 0 |
| LYELL IMMUNOPHARMA INC | Common Stock | 55083R203 |  | 106406 | 3457 | SH |  | SOLE |  | 3457 | 0 | 0 |
| MADRIGAL PHARMACEUTICALS INC | Common Stock | 558868105 |  | 2155240 | 3701 | SH |  | SOLE |  | 3701 | 0 | 0 |
| MEDPACE HOLDINGS INC | Common Stock | 58506Q109 |  | 2577974 | 4590 | SH |  | SOLE |  | 4590 | 0 | 0 |
| JYONG BIOTECH LTD | Common Stock | G83116106 |  | 48937 | 12389 | SH |  | SOLE |  | 12389 | 0 | 0 |
| MEIRAGTX HOLDINGS PLC | Common Stock | G59665102 |  | 104272 | 13116 | SH |  | SOLE |  | 13116 | 0 | 0 |
| MIRUM PHARMACEUTICALS INC | Common Stock | 604749101 |  | 661541 | 8375 | SH |  | SOLE |  | 8375 | 0 | 0 |
| MINERALYS THERAPEUTICS INC | Common Stock | 603170101 |  | 467996 | 12896 | SH |  | SOLE |  | 12896 | 0 | 0 |
| MANNKIND CORP | Common Stock | 56400P706 |  | 283710 | 50037 | SH |  | SOLE |  | 50037 | 0 | 0 |
| DEFINIUM THERAPEUTICS INC | Common Stock | 60255C885 |  | 214936 | 16052 | SH |  | SOLE |  | 16052 | 0 | 0 |
| MODERNA INC | Common Stock | 60770K107 |  | 1877363 | 63661 | SH |  | SOLE |  | 63661 | 0 | 0 |
| MARAVAI LIFESCIENCES HLDGS-A | Common Stock | 56600D107 |  | 76801 | 23631 | SH |  | SOLE |  | 23631 | 0 | 0 |
| NEUROCRINE BIOSCIENCES INC | Common Stock | 64125C109 |  | 2304312 | 16247 | SH |  | SOLE |  | 16247 | 0 | 0 |
| NEUROGENE INC | Common Stock | 64135M105 |  | 51994 | 2524 | SH |  | SOLE |  | 2524 | 0 | 0 |
| NEUMORA THERAPEUTICS INC | Common Stock | 640979100 |  | 48736 | 27227 | SH |  | SOLE |  | 27227 | 0 | 0 |
| NURIX THERAPEUTICS INC | Common Stock | 67080M103 |  | 313346 | 16518 | SH |  | SOLE |  | 16518 | 0 | 0 |
| INTELLIA THERAPEUTICS INC | Common Stock | 45826J105 |  | 169677 | 18874 | SH |  | SOLE |  | 18874 | 0 | 0 |
| NUVALENT INC-A | Common Stock | 670703107 |  | 1183844 | 11769 | SH |  | SOLE |  | 11769 | 0 | 0 |
| NOVAVAX INC | Common Stock | 670002401 |  | 177939 | 26479 | SH |  | SOLE |  | 26479 | 0 | 0 |
| NOVOCURE LTD | Common Stock | G6674U108 |  | 235934 | 18247 | SH |  | SOLE |  | 18247 | 0 | 0 |
| OMNIAB INC | Common Stock | 68218J103 |  | 43395 | 23457 | SH |  | SOLE |  | 23457 | 0 | 0 |
| ORCHESTRA BIOMED HOLDINGS IN | Common Stock | 68572M106 |  | 38184 | 9201 | SH |  | SOLE |  | 9201 | 0 | 0 |
| ORIC PHARMACEUTICALS INC | Common Stock | 68622P109 |  | 129817 | 15870 | SH |  | SOLE |  | 15870 | 0 | 0 |
| ORUKA THERAPEUTICS INC | Common Stock | 687604108 |  | 239085 | 7888 | SH |  | SOLE |  | 7888 | 0 | 0 |
| PACIFIC BIOSCIENCES OF CALIF | Common Stock | 69404D108 |  | 91997 | 49196 | SH |  | SOLE |  | 49196 | 0 | 0 |
| PHIBRO ANIMAL HEALTH CORP-A | Common Stock | 71742Q106 |  | 124484 | 3332 | SH |  | SOLE |  | 3332 | 0 | 0 |
| PUMA BIOTECHNOLOGY INC | Common Stock | 74587V107 |  | 48855 | 8211 | SH |  | SOLE |  | 8211 | 0 | 0 |
| PACIRA BIOSCIENCES INC | Common Stock | 695127100 |  | 181419 | 7010 | SH |  | SOLE |  | 7010 | 0 | 0 |
| VAXCYTE INC | Common Stock | 92243G108 |  | 984212 | 21331 | SH |  | SOLE |  | 21331 | 0 | 0 |
| PEPGEN INC | Common Stock | 713317105 |  | 72925 | 11202 | SH |  | SOLE |  | 11202 | 0 | 0 |
| PRECIGEN INC | Common Stock | 74017N105 |  | 241002 | 57656 | SH |  | SOLE |  | 57656 | 0 | 0 |
| PHATHOM PHARMACEUTICALS INC | Common Stock | 71722W107 |  | 192311 | 11592 | SH |  | SOLE |  | 11592 | 0 | 0 |
| PHARVARIS NV | Common Stock | N69605108 |  | 289655 | 10438 | SH |  | SOLE |  | 10438 | 0 | 0 |
| PRIME MEDICINE INC | Common Stock | 74168J101 |  | 102067 | 29414 | SH |  | SOLE |  | 29414 | 0 | 0 |
| PROTHENA CORP PLC | Common Stock | G72800108 |  | 83773 | 8772 | SH |  | SOLE |  | 8772 | 0 | 0 |
| PERSONALIS INC | Common Stock | 71535D106 |  | 115189 | 14471 | SH |  | SOLE |  | 14471 | 0 | 0 |
| PYXIS ONCOLOGY INC | Common Stock | 747324101 |  | 11668 | 10146 | SH |  | SOLE |  | 10146 | 0 | 0 |
| QUANTUM-SI INC | Common Stock | 74765K105 |  | 35052 | 31865 | SH |  | SOLE |  | 31865 | 0 | 0 |
| UNIQURE NV | Common Stock | N90064101 |  | 242890 | 10150 | SH |  | SOLE |  | 10150 | 0 | 0 |
| RANI THERAPEUTICS HOLDINGS-A | Common Stock | 753018100 |  | 21457 | 15894 | SH |  | SOLE |  | 15894 | 0 | 0 |
| RAPT THERAPEUTICS INC | Common Stock | 75382E208 |  | 152923 | 4515 | SH |  | SOLE |  | 4515 | 0 | 0 |
| ULTRAGENYX PHARMACEUTICAL IN | Common Stock | 90400D108 |  | 361583 | 15721 | SH |  | SOLE |  | 15721 | 0 | 0 |
| ROCKET PHARMACEUTICALS INC | Common Stock | 77313F106 |  | 61899 | 17635 | SH |  | SOLE |  | 17635 | 0 | 0 |
| REPLIMUNE GROUP INC | Common Stock | 76029N106 |  | 124241 | 12782 | SH |  | SOLE |  | 12782 | 0 | 0 |
| REGENXBIO INC | Common Stock | 75901B107 |  | 118786 | 8249 | SH |  | SOLE |  | 8249 | 0 | 0 |
| RIGEL PHARMACEUTICALS INC | Common Stock | 766559702 |  | 126691 | 2958 | SH |  | SOLE |  | 2958 | 0 | 0 |
| RELAY THERAPEUTICS INC | Common Stock | 75943R102 |  | 238936 | 28243 | SH |  | SOLE |  | 28243 | 0 | 0 |
| AVIDITY BIOSCIENCES INC | Common Stock | 05370A108 |  | 1771008 | 24553 | SH |  | SOLE |  | 24553 | 0 | 0 |
| RECURSION PHARMACEUTICALS-A | Common Stock | 75629V104 |  | 342689 | 83787 | SH |  | SOLE |  | 83787 | 0 | 0 |
| RHYTHM PHARMACEUTICALS INC | Common Stock | 76243J105 |  | 1164060 | 10875 | SH |  | SOLE |  | 10875 | 0 | 0 |
| SANA BIOTECHNOLOGY INC | Common Stock | 799566104 |  | 176654 | 43404 | SH |  | SOLE |  | 43404 | 0 | 0 |
| SAGIMET BIOSCIENCES INC-A | Common Stock | 786700104 |  | 29908 | 5052 | SH |  | SOLE |  | 5052 | 0 | 0 |
| SIGA TECHNOLOGIES INC | Common Stock | 826917106 |  | 71298 | 11669 | SH |  | SOLE |  | 11669 | 0 | 0 |
| SOLID BIOSCIENCES INC | Common Stock | 83422E204 |  | 71600 | 12695 | SH |  | SOLE |  | 12695 | 0 | 0 |
| SUMMIT THERAPEUTICS INC | Common Stock | 86627T108 |  | 2121659 | 121307 | SH |  | SOLE |  | 121307 | 0 | 0 |
| SYNDAX PHARMACEUTICALS INC | Common Stock | 87164F105 |  | 297565 | 14163 | SH |  | SOLE |  | 14163 | 0 | 0 |
| ARS PHARMACEUTICALS INC | Common Stock | 82835W108 |  | 187647 | 16107 | SH |  | SOLE |  | 16107 | 0 | 0 |
| SAREPTA THERAPEUTICS INC | Common Stock | 803607100 |  | 367454 | 17075 | SH |  | SOLE |  | 17075 | 0 | 0 |
| SAVARA INC | Common Stock | 805111101 |  | 199925 | 33155 | SH |  | SOLE |  | 33155 | 0 | 0 |
| SPYRE THERAPEUTICS INC | Common Stock | 00773J202 |  | 414217 | 12644 | SH |  | SOLE |  | 12644 | 0 | 0 |
| TARSUS PHARMACEUTICALS INC | Common Stock | 87650L103 |  | 566364 | 6917 | SH |  | SOLE |  | 6917 | 0 | 0 |
| THERAVANCE BIOPHARMA INC | Common Stock | G8807B106 |  | 154488 | 8257 | SH |  | SOLE |  | 8257 | 0 | 0 |
| TEMPUS AI INC | Common Stock | 88023B103 |  | 1663320 | 28168 | SH |  | SOLE |  | 28168 | 0 | 0 |
| ALPHA TEKNOVA INC | Common Stock | 02080L102 |  | 33147 | 8723 | SH |  | SOLE |  | 8723 | 0 | 0 |
| TANGO THERAPEUTICS INC | Common Stock | 87583X109 |  | 194442 | 21946 | SH |  | SOLE |  | 21946 | 0 | 0 |
| TENAYA THERAPEUTICS INC | Common Stock | 87990A106 |  | 19304 | 27132 | SH |  | SOLE |  | 27132 | 0 | 0 |
| ENTRADA THERAPEUTICS INC | Common Stock | 29384C108 |  | 64024 | 6228 | SH |  | SOLE |  | 6228 | 0 | 0 |
| TREVI THERAPEUTICS INC | Common Stock | 89532M101 |  | 261605 | 20895 | SH |  | SOLE |  | 20895 | 0 | 0 |
| TAYSHA GENE THERAPIES INC | Common Stock | 877619106 |  | 245493 | 44635 | SH |  | SOLE |  | 44635 | 0 | 0 |
| TWIST BIOSCIENCE CORP | Common Stock | 90184D100 |  | 316058 | 9964 | SH |  | SOLE |  | 9964 | 0 | 0 |
| 10X GENOMICS INC-CLASS A | Common Stock | 88025U109 |  | 309547 | 18979 | SH |  | SOLE |  | 18979 | 0 | 0 |
| TYRA BIOSCIENCES INC | Common Stock | 90240B106 |  | 228644 | 8697 | SH |  | SOLE |  | 8697 | 0 | 0 |
| UPSTREAM BIO INC | Common Stock | 91678A107 |  | 239083 | 8806 | SH |  | SOLE |  | 8806 | 0 | 0 |
| UROGEN PHARMA LTD | Common Stock | M96088105 |  | 178624 | 7627 | SH |  | SOLE |  | 7627 | 0 | 0 |
| VERICEL CORP | Common Stock | 92346J108 |  | 296758 | 8241 | SH |  | SOLE |  | 8241 | 0 | 0 |
| VERACYTE INC | Common Stock | 92337F107 |  | 542290 | 12881 | SH |  | SOLE |  | 12881 | 0 | 0 |
| VERA THERAPEUTICS INC | Common Stock | 92337R101 |  | 527517 | 10417 | SH |  | SOLE |  | 10417 | 0 | 0 |
| VIR BIOTECHNOLOGY INC | Common Stock | 92764N102 |  | 136700 | 22670 | SH |  | SOLE |  | 22670 | 0 | 0 |
| VANDA PHARMACEUTICALS INC | Common Stock | 921659108 |  | 84937 | 9630 | SH |  | SOLE |  | 9630 | 0 | 0 |
| VOR BIOPHARMA INC | Common Stock | 929033207 |  | 35918 | 2746 | SH |  | SOLE |  | 2746 | 0 | 0 |
| VIATRIS INC | Common Stock | 92556V106 |  | 2336616 | 187680 | SH |  | SOLE |  | 187680 | 0 | 0 |
| VOYAGER THERAPEUTICS INC | Common Stock | 92915B106 |  | 37740 | 9603 | SH |  | SOLE |  | 9603 | 0 | 0 |
| XENON PHARMACEUTICALS INC | Common Stock | 98420N105 |  | 564373 | 12592 | SH |  | SOLE |  | 12592 | 0 | 0 |
| XERIS BIOPHARMA HOLDINGS INC | Common Stock | 98422E103 |  | 212240 | 27037 | SH |  | SOLE |  | 27037 | 0 | 0 |
| XENCOR INC | Common Stock | 98401F105 |  | 178147 | 11636 | SH |  | SOLE |  | 11636 | 0 | 0 |
| ZEVRA THERAPEUTICS INC | Common Stock | 488445206 |  | 82199 | 9174 | SH |  | SOLE |  | 9174 | 0 | 0 |
| ZYMEWORKS INC | Common Stock | 98985Y108 |  | 321094 | 12195 | SH |  | SOLE |  | 12195 | 0 | 0 |
| ARGENX SE - ADR | ADR | 04016X101 |  | 3989467 | 4744 | SH |  | SOLE |  | 4744 | 0 | 0 |
| ASCENDIS PHARMA A/S - ADR | ADR | 04351P101 |  | 2133253 | 10004 | SH |  | SOLE |  | 10004 | 0 | 0 |
| AUTOLUS THERAPEUTICS PLC | ADR | 05280R100 |  | 65047 | 32687 | SH |  | SOLE |  | 32687 | 0 | 0 |
| BICYCLE THERAPEUTICS PLC-ADR | ADR | 088786108 |  | 53383 | 7540 | SH |  | SOLE |  | 7540 | 0 | 0 |
| COMPASS PATHWAYS PLC | ADR | 20451W101 |  | 105936 | 15353 | SH |  | SOLE |  | 15353 | 0 | 0 |
| CENTESSA PHARMACEUTICALS-ADR | ADR | 152309100 |  | 393182 | 15721 | SH |  | SOLE |  | 15721 | 0 | 0 |
| GALAPAGOS NV-SPON ADR | ADR | 36315X101 |  | 77041 | 2356 | SH |  | SOLE |  | 2356 | 0 | 0 |
| GENMAB A/S -SP ADR | ADR | 372303206 |  | 293370 | 9525 | SH |  | SOLE |  | 9525 | 0 | 0 |
| STRUCTURE THERAPEUTICS INC | ADR | 86366E106 |  | 757260 | 10888 | SH |  | SOLE |  | 10888 | 0 | 0 |
| GRIFOLS SA-ADR | ADR | 398438408 |  | 185869 | 19879 | SH |  | SOLE |  | 19879 | 0 | 0 |
| LEGEND BIOTECH CORP-ADR | ADR | 52490G102 |  | 298273 | 13720 | SH |  | SOLE |  | 13720 | 0 | 0 |
| MESOBLAST LTD- SPON ADR | ADR | 590717401 |  | 144176 | 7992 | SH |  | SOLE |  | 7992 | 0 | 0 |
| NOVABRIDGE BIOSCIENCES | ADR | 44975P103 |  | 67421 | 16940 | SH |  | SOLE |  | 16940 | 0 | 0 |
| BEONE MEDICINES LTD-ADR | ADR | 07725L102 |  | 1558241 | 5129 | SH |  | SOLE |  | 5129 | 0 | 0 |
| ZAI LAB LTD-ADR | ADR | 98887Q104 |  | 112543 | 6380 | SH |  | SOLE |  | 6380 | 0 | 0 |

---