# EDGAR Filing Document

**Accession Number:** 0001805387
**File Stem:** 0000950170-23-003564
**Filing Date:** 2023-2
**Character Count:** 27212
**Document Hash:** 2d57fbf5f844007b377bfd1333fdeaaa
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000950170-23-003564.hdr.sgml**: 20230222

**ACCESSION NUMBER**: 0000950170-23-003564

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 15

**CONFORMED PERIOD OF REPORT**: 20230222

**ITEM INFORMATION**: Results of Operations and Financial Condition

**ITEM INFORMATION**: Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20230222

**DATE AS OF CHANGE**: 20230222

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Cerevel Therapeutics Holdings, Inc.
- **CENTRAL INDEX KEY:** 0001805387
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-39311
- **FILM NUMBER:** 23650492

**BUSINESS ADDRESS:**
- **STREET 1:** 222 JACOBS STREET
- **STREET 2:** SUITE 200
- **CITY:** CAMBRIDGE
- **STATE:** MA
- **ZIP:** 02141
- **BUSINESS PHONE:** 844-304-2048

**MAIL ADDRESS:**
- **STREET 1:** 222 JACOBS STREET
- **STREET 2:** SUITE 200
- **CITY:** CAMBRIDGE
- **STATE:** MA
- **ZIP:** 02141

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ARYA Sciences Acquisition Corp II
- **DATE OF NAME CHANGE:** 20200303

?xml version="1.0" encoding="ASCII"? 8-K

**UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549**

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**FORM** 8-K

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**CURRENT REPORT**

**Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934**

**Date of Report (Date of earliest event reported):** February 22, 2023<br>

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CEREVEL THERAPEUTICS HOLDINGS, INC.

**(Exact name of Registrant as Specified in Its Charter)**

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| | | |
|:---|:---|:---|
| Delaware | 001-39311 | 85-3911080 |
| **(State or Other Jurisdiction<br>of Incorporation)** | **(Commission File Number)** | **(IRS Employer<br>Identification No.)** |
| 222 Jacobs Street<br>Suite 200 |  |  |
| Cambridge**,** Massachusetts |  | 02141 |
| **(Address of Principal Executive Offices)** |  | **(Zip Code)** |

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**Registrant's Telephone Number, Including Area Code:** 844 304-2048<br>

Not Applicable

**(Former Name or Former Address, if Changed Since Last Report)**

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Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

**Securities registered pursuant to Section 12(b) of the Act:**

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| | | |
|:---|:---|:---|
| **<br>Title of each class** | **Trading<br>Symbol(s)** | **<br>Name of each exchange on which registered** |
| Common stock, par value $0.0001 per share | CERE | The Nasdaq Stock Market LLC |

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Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

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**Item 2.02 Results of Operations and Financial Condition.**

On February 22, 2023, Cerevel Therapeutics Holdings, Inc. (the "Company") issued a press release announcing financial results for the quarter and year ended December 31, 2022. A copy of the press release is being furnished as Exhibit 99.1 to this Current Report on Form 8-K.

The information contained in this Current Report on Form 8-K and Exhibit 99.1 attached hereto is intended to be furnished and shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such filing.

**Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.**

On February 22, 2023, the Company announced the departure of Abe Ceesay, President. Mr. Ceesay's last day with the Company will be March 9, 2023 (the "Separation Date"). Mr. Ceesay is leaving the Company to become the chief executive officer at a private biotechnology company. The responsibilities Mr. Ceesay has held as President will be distributed among other members of the current management team.

In connection with his departure from the Company, Mr. Ceesay entered into a Separation Agreement (the "Separation Agreement") that provides that, subject to his compliance with and non-revocation of the Separation Agreement, the Company shall waive any right to recovery of Mr. Ceesay's signing bonus and Mr. Ceesay will have a period of six months from the Separation Date to exercise any vested options that he holds. In addition, under the Separation Agreement, Mr. Ceesay provided a general waiver and release of claims in favor of the Company and is subject to certain restrictive covenants, including confidentiality, non-solicitation and non-disparagement. The foregoing description of the Separation Agreement is not complete and is subject to and qualified in its entirety by the terms of the Separation Agreement, a copy of which will be filed as an exhibit to the Company's Quarterly Report on Form 10-Q for the quarter ending March 31, 2023.

 **Item 9.01 Financial Statements and Exhibits.**

(d) Exhibits.

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| | |
|:---|:---|
| Exhibit No. | Description |
| 99.1 | [<u>Press release issued by Cerevel Therapeutics Holdings, Inc. on February 22, 2023, furnished herewith.</u>](cere-ex99_1.htm) |
| 104 | Cover Page Interactive Data File (embedded within the Inline XBRL document)  |

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**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

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| | | | |
|:---|:---|:---|:---|
|  |  |  | CEREVEL THERAPEUTICS HOLDINGS, INC. |
| Date: | February 22, 2023 | By:  | /s/ Mark Bodenrader |
|  |  |  | Mark Bodenrader<br>Interim Chief Financial Officer |

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## Ex-99

**Exhibit 99.1**

![img106327088_0.jpg](img106327088_0.jpg)

**Cerevel Therapeutics Reports Fourth Quarter and Full Year 2022 Financial Results and Business Updates**

Emraclidine Phase 1 healthy elderly volunteer trial enrollment underway to support development in Alzheimer's disease psychosis

Emraclidine Phase 2 schizophrenia data readout remains on track for 1H 2024

Clinical trial timeline updates provided for additional lead programs

Cash, cash equivalents, and marketable securities of $950 million as of December 31, 2022, expected to support operations into 2025

Conference call today at 8:00 a.m. ET

**CAMBRIDGE**, **Mass**., February 22, 2023 – Cerevel Therapeutics, (Nasdaq: CERE), a company dedicated to unraveling the mysteries of the brain to treat neuroscience diseases, today reported financial results for the fourth quarter and full year ended December 31, 2022 and provided key pipeline and business updates.

"Cerevel is progressing in its quest to become the premier neuroscience company, and 2022 was another important year in that journey," said Tony Coles, M.D., chairman and chief executive officer of Cerevel Therapeutics. "From the positive results in our emraclidine blood pressure trial that were announced recently to the strengthening of our balance sheet with a nearly $600 million capital raise mid-year, Cerevel continues to achieve critical milestones that support our mission to change what is possible in neuroscience. With targeted investments in the pipeline supported by strong fiscal discipline, we expect to continue that momentum forward through 2023 and beyond."

**Pipeline Highlights**

Leveraging its deep understanding of neurocircuitry and targeted receptor subtype selectivity, Cerevel is advancing its broad and diverse pipeline of novel neuroscience product candidates.

Below are the latest updates for Cerevel's lead programs.

**<u>Emraclidine</u>:** an M4-selective positive allosteric modulator (PAM) in development for schizophrenia and Alzheimer's disease psychosis.

-In June 2022, Cerevel initiated its Phase 2 program in schizophrenia, in which emraclidine is being studied as a once-daily medication without the need for titration.

oCerevel is conducting two adequately-powered placebo-controlled Phase 2 trials, known as EMPOWER-1 and EMPOWER-2. Enrollment for these trials is on track and data for both trials are expected in the first half of 2024.

oThe 52-week open-label safety extension trial, EMPOWER-3, is also continuing enrollment.

-To support a potential registrational package for emraclidine in schizophrenia, Cerevel is prioritizing the completion of the necessary nonclinical and clinical pharmacology studies.

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![img106327088_1.jpg](img106327088_1.jpg)

oCerevel recently announced positive data in a Phase 1 ambulatory blood pressure monitoring trial that has provided clear evidence that emraclidine does not induce an increase in blood pressure with chronic dosing in people living with schizophrenia, an important risk-mitigating step for continued development.

-To support development of a second potential indication for Alzheimer's disease psychosis, Cerevel initiated a Phase 1 multiple ascending dose trial in the fourth quarter of 2022 to evaluate the safety, tolerability and pharmacokinetics of emraclidine in healthy elderly volunteers, 65-85 years old.

oThe FDA granted Fast Track designation for emraclidine for the treatment of hallucinations and delusions associated with Alzheimer's disease psychosis.

**<u>Darigabat</u>:** an α2/3/5-selective GABAA receptor PAM currently under development for epilepsy and panic disorder.

-Cerevel is conducting the REALIZE trial, a Phase 2 proof-of-concept trial in focal epilepsy.

oEnrollment in the REALIZE trial has been impacted due to the residual post-COVID environment and other factors that are resulting in slower-than-expected enrollment in many clinical trials. As a result, the Company anticipates a delay in the REALIZE readout beyond 2023. Following a detailed review of all environmental factors, the Company plans to provide updated timing on the REALIZE readout by mid-year.

-Cerevel also plans to initiate a Phase 2 proof-of-concept panic disorder trial in the second quarter of 2023.

oBased on the positive topline results reported in February 2022 for the Phase 1 trial of darigabat in healthy volunteers in a panic symptoms model, Cerevel has selected panic disorder as the second indication for development of darigabat.

**<u>Tavapadon</u>:** a D1/D5 partial agonist currently in Phase 3 for the treatment of Parkinson's disease.

-Tavapadon has the potential to be a first-in-class D1/D5 selective partial agonist for Parkinson's disease, as both monotherapy and adjunctive treatment.

-All three of Cerevel's Phase 3 trials as monotherapy (early-stage) and adjunctive (late-stage) in Parkinson's disease (TEMPO-1, -2, and -3) are ongoing, along with the corresponding open-label extension trial (TEMPO-4).

-Following a detailed review of all environmental factors, Cerevel now expects data from TEMPO-3 in mid-year 2024 and TEMPO-1 and TEMPO- 2 in the second half of 2024.

**<u>CVL-871</u>:** a D1/D5 partial agonist in development for treatment of dementia-related apathy.

-Cerevel is conducting a Phase 2a exploratory trial in dementia-related apathy.

-Following a review of timelines and factors affecting enrollment, data is now expected for this trial in the second half of 2024.

In addition to these lead programs, Cerevel is advancing its early clinical pipeline and discovery programs, which include:

-**CVL-354**, a selective kappa opioid receptor antagonist (KORA), for the treatment of major depressive disorder and substance use disorder.

-**Selective M4 agonist** program for the treatment of psychiatric and neurological indications.

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![img106327088_1.jpg](img106327088_1.jpg)

-**Selective PDE4 inhibitor** (PDE4D-sparing) program for the treatment of psychiatric, neuroinflammatory and other disorders.

**Financial Results for the Fourth Quarter and Full Year 2022**

-**Cash Position:** Cash, cash equivalents and marketable securities as of December 31, 2022, were $950.2 million, compared to $618.0 million as of December 31, 2021. Relative to 2021, the increase in Cerevel's cash position primarily reflects $573.0 million of net proceeds received from our August 2022 follow-on public offering of common stock and concurrent issuance of convertible notes, partially offset by cash used in operations.

-**R&D Expenses:** Research and development expense for the fourth quarter and full year ended December 31, 2022 were $81.3 million and $280.3 million, respectively. This compares to $47.8 million and $161.9 million, respectively, for the fourth quarter and full year ended December 31, 2021. R&D expense for the fourth quarter and year ended December 31, 2022, include $5.0 million and $18.2 million of stock-based compensation expense, compared to $2.8 million and $9.2 million for the prior year periods, respectively. Compared to the same periods in the prior year, the increases in R&D expense were primarily attributable to the continued advancement of Cerevel's clinical programs for emraclidine, tavapadon and darigabat; increased investment in early discovery efforts; and increased personnel and other infrastructure costs to support continued growth and advancement of the pipeline.

-**G&A Expenses:** General and administrative expense for the fourth quarter and full year ended December 31, 2022, were $25.9 million and $87.6 million, respectively. This compares to $16.6 million and $58.2 million, respectively, for the fourth quarter and full year ended December 31, 2021. G&A expenses for the fourth quarter and year ended December 31, 2022, include $5.4 million and $20.6 million of stock-based compensation expense, compared to $3.7 million and $14.7 million, respectively, for the prior year periods. Compared to the same periods in the prior year, the increases in G&A expense were primarily driven by increased personnel costs and other costs to support organizational growth and the advancement of our programs.

**Financial Outlook**

-Cerevel anticipates R&D expenses for 2023 to increase relative to 2022, driven by increased costs associated with the advancement of the ongoing comprehensive Phase 2 program for emraclidine in schizophrenia; the recently initiated Phase 1 trial of emraclidine in healthy elderly volunteers to support development in Alzheimer's disease psychosis; the expected initiation of the Phase 2 trial of darigabat in panic disorder; and incremental personnel costs to support the growth and advancement of the pipeline.

-Cerevel expects G&A expenses to remain relatively consistent for 2023, as compared to the fourth quarter of 2022.

-**Cerevel's cash, cash equivalents, and marketable securities are expected to continue to support operations into 2025.**

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![img106327088_1.jpg](img106327088_1.jpg)

<br>**President Abraham Ceesay to Depart March 9**<br>Cerevel also announced today that President Abraham Ceesay will leave the organization as of March 9, 2023 to become the chief executive officer at a private biotechnology company.

**Conference Call Information**

Cerevel will host a conference call and webcast today, February 22, at 8:00 a.m. ET to discuss its fourth quarter and full year 2022 financial results and pipeline updates. To access the call, please register at this link. Once registered, you will receive the dial-in information and a unique PIN number.

<br>A live webcast of the call, along with supporting slides, will be available on the investors section of Cerevel's website at investors.cerevel.com. Following the live webcast, an archived version of the call will be available on the website.

**About Cerevel Therapeutics**<br>Cerevel Therapeutics is dedicated to unraveling the mysteries of the brain to treat neuroscience diseases. The company is tackling diseases by combining its deep expertise in neurocircuitry with a focus on targeted receptor subtype selectivity and a differentiated approach to pharmacology. Cerevel Therapeutics has a diversified pipeline comprising five clinical-stage investigational therapies and several preclinical compounds with the potential to treat a range of neuroscience diseases, including schizophrenia, Alzheimer's disease psychosis, epilepsy, panic disorder, and Parkinson's disease. Headquartered in Cambridge, Mass., Cerevel Therapeutics is advancing its current research and development programs while exploring new modalities through internal research efforts, external collaborations, or potential acquisitions. For more information, visit www.cerevel.com.

**Special Note Regarding Forward-Looking Statements**<br>This press release contains forward-looking statements that are based on management's beliefs and assumptions and on information currently available to management. In some cases, you can identify forward-looking statements by the following words: "may," "will," "could," "would," "should," "expect," "intend," "plan," "anticipate," "believe," "estimate," "predict," "project," "potential," "continue," "ongoing" or the negative of these terms or other comparable terminology, although not all forward-looking statements contain these words. These statements involve risks, uncertainties and other factors that may cause actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. Although we believe that we have a reasonable basis for each forward-looking statement contained in this press release, we caution you that these statements are based on a combination of facts and factors currently known by us and our projections of the future, about which we cannot be certain. Forward-looking statements in this press release include, but are not limited to, statements about: the potential attributes and benefits of our product candidates; the format, timing and objectives of our product development activities and clinical trials, including plans to provide updated timing on the REALIZE readout at a future date; the timing and outcome of regulatory interactions, including whether activities meet the criteria to serve as registrational; the ability to compete with other companies currently marketing or engaged in the development of treatments for relevant indications; the size and growth potential of the markets for product candidates and ability to serve those markets; the

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![img106327088_1.jpg](img106327088_1.jpg)

rate and degree of market acceptance of product candidates, if approved; our financial outlook, including with respect to our funding plans; and the sufficiency of our cash runway. We cannot assure you that the forward-looking statements in this press release will prove to be accurate. Furthermore, if the forward-looking statements prove to be inaccurate, the inaccuracy may be material. Actual performance and results may differ materially from those projected or suggested in the forward-looking statements due to various risks and uncertainties, including, among others: clinical trial results may not be favorable; uncertainties inherent in the product development process (including with respect to the timing of results and whether such results will be predictive of future results); the impact of COVID-19, the post-COVID environment and other factors on the timing, progress and results of clinical trials; our ability to recruit and enroll suitable patients in our clinical trials; whether and when, if at all, our product candidates will receive approval from the FDA or other regulatory authorities, and for which, if any, indications; competition from other biotechnology companies; uncertainties regarding intellectual property protection; and other risks identified in our SEC filings, including those under the heading "Risk Factors" in our Quarterly Report on Form 10-Q filed with the SEC on November 8, 2022 and our subsequent SEC filings. In light of the significant uncertainties in these forward-looking statements, you should not regard these statements as a representation or warranty by us or any other person that we will achieve our objectives and plans in any specified time frame, or at all. The forward-looking statements in this press release represent our views as of the date of this press release. We anticipate that subsequent events and developments will cause our views to change. However, while we may elect to update these forward-looking statements at some point in the future, we have no current intention of doing so except to the extent required by applicable law. You should, therefore, not rely on these forward-looking statements as representing our views as of any date subsequent to the date of this press release.

\# \# \#

**Media Contact:**

Anna Robinson

Cerevel Therapeutics

anna.robinson@cerevel.com

**Investor Contact:**

Matthew Calistri

Cerevel Therapeutics

matthew.calistri@cerevel.com

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![img106327088_1.jpg](img106327088_1.jpg)

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| | | | | |
|:---|:---|:---|:---|:---|
| TABLE 1 | TABLE 1 | TABLE 1 | TABLE 1 | TABLE 1 |
| CEREVEL THERAPEUTICS HOLDINGS, INC. | CEREVEL THERAPEUTICS HOLDINGS, INC. | CEREVEL THERAPEUTICS HOLDINGS, INC. | CEREVEL THERAPEUTICS HOLDINGS, INC. | CEREVEL THERAPEUTICS HOLDINGS, INC. |
| CONSOLIDATED STATEMENTS OF OPERATIONS | CONSOLIDATED STATEMENTS OF OPERATIONS | CONSOLIDATED STATEMENTS OF OPERATIONS | CONSOLIDATED STATEMENTS OF OPERATIONS | CONSOLIDATED STATEMENTS OF OPERATIONS |
| (unaudited, in thousands, except share amounts and per share amounts) | (unaudited, in thousands, except share amounts and per share amounts) | (unaudited, in thousands, except share amounts and per share amounts) | (unaudited, in thousands, except share amounts and per share amounts) | (unaudited, in thousands, except share amounts and per share amounts) |
|  | **For the Three Months Ended<br>December 31,** | **For the Three Months Ended<br>December 31,** | **For the Twelve Months Ended<br>December 31,** | **For the Twelve Months Ended<br>December 31,** |
|  | **2022** | **2021** | **2022** | **2021** |
| Operating expenses: |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Research and development | $81312 | $47841 | $280259 | $161855 |
| &nbsp;&nbsp;&nbsp;General and administrative | 25935 | 16649 | 87589 | 58243 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total operating expenses | 107247 | 64490 | 367848 | 220098 |
| Loss from operations | (107247) | (64490) | (367848) | (220098) |
| Interest income (expense), net | 5951 | 119 | 9619 | 157 |
| Other income (expense), net | 8648 | 5316 | 6878 | (5393) |
| Loss before income taxes | (92648) | (59055) | (351351) | (225334) |
| Income tax benefit (provision), net | (160) | 0 | (160) | 0 |
| Net loss | $(92808) | $(59055) | $(351511) | $(225334) |
| Reconciliation of net loss attributable to common stockholders: |  |  |  |  |
| Net loss | $(92808) | $(59055) | $(351511) | $(225334) |
| Net loss per share, basic and diluted | $(0.59) | $(0.40) | $(2.32) | $(1.65) |
| Weighted-average shares used in calculating net loss per share, basic and diluted | 156373651 | 147302283 | 151265635 | 136576536 |

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![img106327088_1.jpg](img106327088_1.jpg)

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| | | |
|:---|:---|:---|
| TABLE 2 | TABLE 2 | TABLE 2 |
| CEREVEL THERAPEUTICS HOLDINGS, INC. | CEREVEL THERAPEUTICS HOLDINGS, INC. | CEREVEL THERAPEUTICS HOLDINGS, INC. |
| CONDENSED CONSOLIDATED BALANCE SHEETS | CONDENSED CONSOLIDATED BALANCE SHEETS | CONDENSED CONSOLIDATED BALANCE SHEETS |
| (unaudited, in thousands) | (unaudited, in thousands) | (unaudited, in thousands) |
|  | **As of December 31,** | **As of December 31,** |
|  | **2022** | **2021** |
| **ASSETS** |  |  |
| Current assets: |  |  |
| &nbsp;&nbsp;&nbsp;Cash and cash equivalents | $136521 | $193018 |
| &nbsp;&nbsp;&nbsp;Marketable securities | 755509 | 372670 |
| &nbsp;&nbsp;&nbsp;Prepaid expenses and other current assets | 13621 | 12329 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total current assets | 905651 | 578017 |
| Marketable securities | 58126 | 52269 |
| Property and equipment, net | 27467 | 28449 |
| Operating lease assets | 21820 | 23251 |
| Restricted cash | 1867 | 4200 |
| Other long-term assets | 2891 | 2733 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total assets | $1017822 | $688919 |
| **LIABILITIES AND STOCKHOLDERS' EQUITY** |  |  |
| Current liabilities | $72564 | $42538 |
| Operating lease liabilities, net of current portion | 31190 | 34110 |
| 2027 convertible senior notes, net | 335482 |  |
| Financing liabilities and other long-term liabilities | 57348 | 33542 |
| Total stockholders' equity | 521238 | 578729 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total liabilities and stockholders' equity | $1017822 | $688919 |

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![img106327088_1.jpg](img106327088_1.jpg)

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| | | |
|:---|:---|:---|
| TABLE 3 | TABLE 3 | TABLE 3 |
| CEREVEL THERAPEUTICS HOLDINGS, INC. | CEREVEL THERAPEUTICS HOLDINGS, INC. | CEREVEL THERAPEUTICS HOLDINGS, INC. |
| CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS | CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS | CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS |
| (unaudited, in thousands) | (unaudited, in thousands) | (unaudited, in thousands) |
|  | **For the year ended<br>December 31,** | **For the year ended<br>December 31,** |
|  | **2022** | **2021** |
| Net cash flows used in operating activities | $(293187) | $(178546) |
| Net cash flows used in investing activities | (388834) | (435661) |
| Net cash flows provided by financing activities | 623191 | 423602 |
| &nbsp;&nbsp;&nbsp;Net increase (decrease) in cash, cash equivalents, and restricted cash | (58830) | (190605) |
| &nbsp;&nbsp;&nbsp;Cash, cash equivalents and restricted cash, beginning of the period | 197218 | 387823 |
| &nbsp;&nbsp;&nbsp;Cash, cash equivalents and restricted cash, end of the period | $138388 | $197218 |

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<u>Note:</u>

Cash, cash equivalents and restricted cash balances include restricted cash of $1.9 million and $4.2 million as of December 31, 2022 and December 31, 2021, respectively.

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