# EDGAR Filing Document

**Accession Number:** 0001095981
**File Stem:** 0001193125-26-104218
**Filing Date:** 2026-3
**Character Count:** 26569
**Document Hash:** 8259d198d53e86ae2cefaa1258e53514
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-26-104218.hdr.sgml**: 20260312

**ACCESSION NUMBER**: 0001193125-26-104218

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 11

**CONFORMED PERIOD OF REPORT**: 20260312

**ITEM INFORMATION**: Results of Operations and Financial Condition

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20260312

**DATE AS OF CHANGE**: 20260312

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** PLUS THERAPEUTICS, INC.
- **CENTRAL INDEX KEY:** 0001095981
- **STANDARD INDUSTRIAL CLASSIFICATION:** SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
- **ORGANIZATION NAME:** 08 Industrial Applications and Services
- **EIN:** 330827593
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-34375
- **FILM NUMBER:** 26748072

**BUSINESS ADDRESS:**
- **STREET 1:** 4200 MARATHON BLVD.
- **STREET 2:** SUITE 200
- **CITY:** AUSTIN
- **STATE:** TX
- **ZIP:** 78756
- **BUSINESS PHONE:** 737.255.7194

**MAIL ADDRESS:**
- **STREET 1:** 4200 MARATHON BLVD.
- **STREET 2:** SUITE 200
- **CITY:** AUSTIN
- **STATE:** TX
- **ZIP:** 78756

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** CYTORI THERAPEUTICS, INC.
- **DATE OF NAME CHANGE:** 20050712

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** MACROPORE INC
- **DATE OF NAME CHANGE:** 20010320

?xml version='1.0' encoding='ASCII'? 8-K

**UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549**

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## FORM 8-K

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**CURRENT REPORT**

**Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934**

**Date of Report (Date of earliest event reported):** March 12, 2026<br>

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PLUS THERAPEUTICS, INC.

**(Exact name of Registrant as Specified in Its Charter)**

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| | | |
|:---|:---|:---|
| Delaware | 001-34375 | 33-0827593 |
| **(State or Other Jurisdiction<br>of Incorporation)** | **(Commission File Number)** | **(IRS Employer<br>Identification No.)** |
| 6420 LEVIT GREEN BOULEVARD<br>Suite 310 |  |  |
| Houston**,** Texas |  | 77021 |
| **(Address of Principal Executive Offices)** |  | **(Zip Code)** |

---

**Registrant's Telephone Number, Including Area Code:** (737) 255-7194<br>

**(Former Name or Former Address, if Changed Since Last Report)**

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Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

**Securities registered pursuant to Section 12(b) of the Act:**

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| | | |
|:---|:---|:---|
| **<br>Title of each class** | **Trading<br>Symbol(s)** | **<br>Name of each exchange on which registered** |
| Common Stock, par value $0.001 per share | PSTV | The Nasdaq Capital Market |

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Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

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## Item 2.02 Results of Operations and Financial Condition.
On March 12, 2026, Plus Therapeutics, Inc. (the "Company") reported financial results for the fourth quarter and year ended December 31, 2025 and other recent corporate updates. A copy of the press release is furnished as Exhibit 99.1 to this report and incorporated by reference.

The information in this Item 2.02 of this Current Report on Form 8-K (including Exhibit 99.1) is furnished and shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or subject to the liabilities of that section or Sections 11 and 12(a)(2) of the Securities Act of 1933, as amended. The information shall not be deemed incorporated by reference into any other filing with the Securities and Exchange Commission made by the Company, whether made before or after today's date, regardless of any general incorporation language in such filing, except as shall be expressly set forth by specific references in such filing.

## Item 9.01 Financial Statements and Exhibits.

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| | |
|:---|:---|
| **(d) Exhibits.**<br>**Exhibit<br>Number** | <br>**Description** |
| [<u>99.1</u>](pstv-ex99_1.htm) | [<u>Press Release Announcing Financial Results, dated March 12, 2026</u>](pstv-ex99_1.htm) |
| 104 | <u>Cover Page Interactive Data File (embedded within the Inline XBRL document)</u> |

---

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**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

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| | | | |
|:---|:---|:---|:---|
|  |  |  | PLUS THERAPEUTICS, INC.  |
| Date: | March 12, 2026 | By:  | /s/ Marc H. Hedrick, M.D.  |
|  |  |  | Marc H. Hedrick, M.D.<br>President and Chief Executive Officer  |

---

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## Exhibit 99.1

**Exhibit 99.1**

**Plus Therapeutics Reports 2025 Results, Business Progress and 2026 Anticipated Milestones for REYOBIQ™ Clinical Program and CNSide® Commercial Rollout**

**HOUSTON, Texas, March 12, 2026 (GLOBE NEWSWIRE)** – Plus Therapeutics, Inc. (Nasdaq: PSTV) ("Plus" or the "Company"), a healthcare company developing and commercializing precision diagnostics and radiopharmaceuticals for central nervous system (CNS) cancers, today announces financial results for the fourth quarter and year ended December 31, 2025 and provides an overview of recent and upcoming business highlights.

"Our team remains highly focused on achieving our 2026 targets," said Marc H. Hedrick, M.D., Plus Therapeutics President and Chief Executive Officer. "Specifically, our top priority goals are CNSide commercial scale-up and REYOBIQ pivotal trial readiness; we also are looking aggressively for ways to over achieve where possible."

**Q4 2025 AND RECENT HIGHLIGHTS** 

***<u>Corporate</u>***

• Completed an upsized public offering generating $15 million in gross proceeds, extending the Company's projected cash runway and supporting CNSide commercialization and advancement of two ongoing Phase 2 clinical programs

***<u>REYOBIQ™ Development</u>***

• Secured American Medical Association Category III CPT <u>reimbursement</u> code for convection-enhanced delivery with REYOBIQ, unlocking market access and growth potential of REYOBIQ therapy in recurrent glioblastoma and pediatric brain cancer

• Incorporating constructive <u>Type B meeting</u> feedback from the FDA to help accelerate clinical development timelines and facilitate submission of application for the approval of REYOBIQ for patients with leptomeningeal metastases (LM)

• Highlighted three REYOBIQ clinical data presentations at the World Federation of Neuro-Oncology Societies/Society for Neuro-Oncology (<u>WFNOS/SNO</u>), building upon body of real world clinical experience with REYOBIQ in both primary and metastatic CNS cancers that continue to show promising safety profile and signs of efficacy

***<u>CNSide CSF Assay Platform</u>***

• Expanded CNSide laboratory licensing to 49 of 50 U.S. states, having recently added Pennsylvania and <u>California</u>; enables access to CNSide Tumor Cell Enumeration (TCE) test to approximately 95% of the U.S. population

• Continued to expand the CNSide Diagnostics team to support national test adoption

• Announced second of planned national coverage agreements with <u>Humana</u> effective October 29, 2025. Combined with <u>UnitedHealthcare</u> national coverage agreement, CNSide CSF laboratory test policy coverage now reaches approximately 67 million people throughout the U.S.

**Full Year 2025 FINANCIAL RESULTS**

• The Company's cash and investments balance was $13.1 million on December 31, 2025 compared to $3.6 million on December 31, 2024

• Recognized $5.2 million in grant revenue in the year ending December 31, 2025 and $5.8 million for the year ending December 31, 2024, which in both periods represents CPRIT's share of the costs incurred for the advancement of our REYOBIQ development for the treatment of patients with LM

• Total operating loss for the year ending December 31, 2025 was $15.3 million versus $14.7 million for the year ending December 31, 2024, with the increase primarily attributed to expansion of the CNSide operations team

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• Net loss for the year ending December 31, 2025 was $22.4 million, or $(0.29) per basic share versus $13.0 million, or $(1.95) per basic share, for the year ending December 31, 2024. The change in the net loss for the year ended December 31 was primarily due to change in fair value of derivative instruments from the Q1 2025 financings

**Anticipated MILESTONES and OUTLOOK for 2026**

**REYOBIQ clinical program:**

• Define optimal dose/interval for REYOBIQ in the ReSPECT-LM Phase 2 trial; anticipate reporting data in Q3 2026

• Completing enrollment in the ReSPECT-GBM Phase 2 trial for glioblastoma and conduct an End of Phase meeting with FDA with the goal of aligning on pivotal trial design. Data expected in Q4 2026

• Complete commercial manufacturing scale up for REYOBIQ

• Begin enrollment in the ReSPECT-PBC pediatric brain cancer Phase 1 trial

The Company expects research and development expenditures to increase in 2026 compared to 2025, due to increased costs for the ReSPECT-LM clinical trial, manufacturing scale up for REYOBIQ commercial and approval trial drug availability, and initial patient enrollments in the ReSPECT-PBC clinical trial, together with expansion of CNSide research and development teams.

**CNSide commercial roll out:**

• Expand U.S. commercial payer coverage to >150 million covered lives

• Secure Medicare coverage pathway

• Achieve > 1,250 annualized test orders

• Launch additional CSF tumor characterization assays to expand the CNSide platform

The Company expects general and administrative expenditures to increase in 2026 as compared to 2025 due to expanded CNSide commercial operations team (including sales, customer service and laboratory operations), such that the goal is for CNSide Diagnostics to breakeven by 2027.

**About Leptomeningeal metastases (LM)**

Leptomeningeal metastases (LM) are a rare but severe complication of advanced cancer, affecting the fluid-lined structures of the central nervous system. LM occurs in approximately 5% of patients with metastatic cancer, with breast cancer, lung cancer, and melanoma being the most common sources. Median survival is typically 2-6 months, and effective treatment options are limited, highlighting the urgent need for novel therapies.

**About REYOBIQ™ (rhenium Re186 obisbemeda)**

REYOBIQ (rhenium Re186 obisbemeda) is a novel injectable radiotherapy specifically formulated to deliver direct targeted high dose radiation in CNS tumors in a safe, effective, and convenient manner to optimize patient outcomes. REYOBIQ has the potential to reduce off target risks and improve outcomes for CNS cancer patients, versus currently approved therapies, with a more targeted and potent radiation dose. Rhenium-186 is an ideal radioisotope for CNS therapeutic applications due to its short half-life, beta energy for destroying cancerous tissue, and gamma energy for real-time imaging. REYOBIQ is being evaluated for the treatment of recurrent glioblastoma, leptomeningeal metastases, and pediatric brain cancer in the ReSPECT-GBM, ReSPECT-LM, and ReSPECT-PBC clinical trials. ReSPECT-GBM is supported by an award from the National Cancer Institute (NCI), part of the U.S. National Institutes of Health (NIH), and ReSPECT-LM is funded by a three-year $17.6M grant by the Cancer Prevention & Research Institute of Texas (CPRIT). The Company's ReSPECT-PBC clinical trial for pediatric brain cancer is supported by a $3 million grant from the U.S. Department of Defense's Peer Reviewed Cancer Research Program.

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**About CNSide Diagnostics, LLC**

CNSide Diagnostics, LLC is a wholly owned subsidiary of Plus Therapeutics, Inc. that develops and commercializes proprietary laboratory-developed tests, such as CNSide®, designed to identify tumor cells that have metastasized to the central nervous system in patients with carcinomas and melanomas. The CNSide® CSF Assay Platform enables quantitative analysis of the cerebrospinal fluid that informs and improves the management of patients with leptomeningeal metastases.

**About Plus Therapeutics**

Headquartered in Houston, Texas, Plus Therapeutics, Inc. is a clinical-stage pharmaceutical company developing targeted radiotherapeutics for difficult-to-treat cancers of the central nervous system with the potential to enhance clinical outcomes. Combining image-guided local beta radiation and targeted drug delivery approaches, the Company is advancing a pipeline of product candidates with lead programs in leptomeningeal metastases (LM) and recurrent glioblastoma (GBM). The Company has built a supply chain through strategic partnerships that enable the development, manufacturing, and future potential commercialization of its products.

**Forward-Looking Statements**

This press release contains statements that may be deemed "forward-looking statements" within the meaning of U.S. securities laws. All statements in this press release other than statements of historical fact are forward-looking statements. These forward-looking statements may be identified by future verbs, as well as terms such as "expect," "anticipate" "intend," "believe," "estimate," "will," and similar expressions or the negatives thereof. Such statements are based upon certain assumptions and assessments made by management in light of their experience and their perception of historical trends, current conditions, expected future developments and other factors they believe to be appropriate. The forward-looking statements included in this press release could differ materially from those expressed or implied by these forward-looking statements because of risks, uncertainties, and other factors that include, but are not limited to, the following: the Company's ability to maintain the listing of its common stock on Nasdaq; the early stage of the Company's product candidates and therapies; the results of the Company's research and development activities, including uncertainties relating to the clinical trials of its product candidates and therapies; the Company's liquidity position and capital resources and its ability to raise additional cash; the outcome of the Company's partnering/licensing efforts; risks associated with laws or regulatory requirements applicable to the Company; market conditions, product performance, litigation or potential litigation, and competition within the cancer diagnostics and therapeutics field; ability to develop and protect proprietary intellectual property or obtain licenses to intellectual property developed by others on commercially reasonable and competitive terms; challenges associated with radiotherapeutic manufacturing, production and distribution capabilities necessary to support the Company's clinical trials and any commercial level product demand; statements regarding the potential market for the CNSide CSF Assay Platform, the timing in which the CNSide CSF Assay commercialization is expanded, revenue and corporate profitability expectations including support reimbursements and payments for the CNSide CSF Assay, the development and utility of the CNSide CSF Assay and expectations as to the Company's future performance, including the next steps in developing the Company's product candidates and material security breach or cybersecurity attack affecting the Company's operations or property. This list of risks, uncertainties, and other factors is not complete. Any or all forward-looking statements the Company makes may turn out to be wrong and can be affected by inaccurate assumptions the Company might make or by known or unknown risks, uncertainties, and other factors, including those identified in this press release. This list of risks, uncertainties, and other factors is not complete. Plus Therapeutics discusses some of these matters more fully, as well as certain risk factors that could affect Plus Therapeutics' business, financial condition, results of operations, and prospects, in its reports filed with the SEC, including Plus Therapeutics' annual report on Form 10-K for the fiscal year ended December 31, 2025, quarterly reports on Form 10-Q, and current reports on Form 8-K. These filings are available for review through the SEC's website at www.sec.gov. Any or all forward-looking statements Plus Therapeutics makes may turn out to be wrong and can be affected by inaccurate assumptions Plus Therapeutics might make or by known or unknown risks, uncertainties, and other factors, including those identified in this press release. Accordingly, you should not place undue reliance on the

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forward-looking statements made in this press release, which speak only as of its date. There may be events in the future that the Company is unable to predict, or over which it has no control, and its business, financial condition, results of operations and prospects may change in the future. The Company assumes no responsibility to update or revise any forward-looking statements to reflect events, trends or circumstances after the date they are made unless the Company has an obligation under U.S. federal securities laws to do so.

**<u>Investor Contact</u>**

<br> CORE IR<br>investor@plustherapeutics.com

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**PLUS THERAPEUTICS, INC.**

**CONSOLIDATED BALANCE SHEETS**

**(in thousands, except share and par value data)**

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| | | |
|:---|:---|:---|
|  | **As of December 31,** | **As of December 31,** |
|  | **2025** | **2024** |
| **Assets** |  |  |
| Current assets: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Cash and cash equivalents | $4256 | $76 |
| &nbsp;&nbsp;&nbsp;&nbsp;Restricted cash and cash equivalents | 4502 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Investments | 4356 | 3530 |
| &nbsp;&nbsp;&nbsp;&nbsp;Grant receivable | 322 | 571 |
| &nbsp;&nbsp;&nbsp;&nbsp;Other current assets | 1734 | 1082 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total current assets | 15170 | 5259 |
| Property and equipment, net | 257 | 448 |
| Operating lease right-of-use assets | 70 | 73 |
| Goodwill | 372 | 372 |
| Intangible assets, net | 333 | 469 |
| Other assets | 123 | 12 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total assets | $16325 | $6633 |
| **Liabilities and Stockholders' Equity (Deficit)** |  |  |
| Current liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Accounts payable and accrued expenses | $5920 | $11288 |
| &nbsp;&nbsp;&nbsp;&nbsp;Investor liability pursuant to Letter Agreement | 4502 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Operating lease liability | 56 | 44 |
| &nbsp;&nbsp;&nbsp;&nbsp;Deferred grant liability | 927 | 927 |
| &nbsp;&nbsp;&nbsp;&nbsp;Other liabilities | 159 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Line of credit | 750 | 3292 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total current liabilities | 12314 | 15551 |
| Noncurrent operating lease liability | 15 | 31 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total liabilities | 12329 | 15582 |
| Stockholders' equity (deficit): |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Preferred stock, $0.001 par value; 5,000,000 shares authorized; 1,952<br> shares issued and outstanding as of December 31, 2025 and 2024 |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Common stock, $0.001 par value; 2,000,000,000 shares authorized; 138,934,281 shares issued and 138,675,856 outstanding as of December 31, 2025, 100,000,000 shares authorized; 6,154,758 shares issued and 5,896,333 outstanding as of December 31, 2024, respectively | 139 | 6 |
| &nbsp;&nbsp;&nbsp;&nbsp;Treasury stock (at cost), 258,425 shares as of December 31, 2025 and 2024, respectively | (500) | (500) |
| &nbsp;&nbsp;&nbsp;&nbsp;Additional paid-in capital | 520222 | 485024 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accumulated deficit | (515865) | (493479) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total stockholders' equity (deficit) | 3996 | (8949) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total liabilities and stockholders' equity | $16325 | $6633 |

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**PLUS THERAPEUTICS, INC.**

**CONSOLIDATED STATEMENTS OF OPERATIONS** 

**(in thousands, except share and per share data)**

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| | | |
|:---|:---|:---|
|  | **For the Years Ended December 31,** | **For the Years Ended December 31,** |
|  | **2025** | **2024** |
| Grant revenue | $5213 | $5824 |
| Operating expenses: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Research and development | 8379 | 10580 |
| &nbsp;&nbsp;&nbsp;&nbsp;General and administrative | 12132 | 9939 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total operating expenses | 20511 | 20519 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Operating loss | (15298) | (14695) |
| Other income (expense): |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Financing expense | (3061) | (3545) |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in fair value of derivative instruments | (2631) | 5654 |
| &nbsp;&nbsp;&nbsp;&nbsp;Warrant issuance costs | (964) | (486) |
| &nbsp;&nbsp;&nbsp;&nbsp;Interest income | 116 | 273 |
| &nbsp;&nbsp;&nbsp;&nbsp;Interest expense | (548) | (179) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total other income (expense) | (7088) | 1717 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net loss | $(22386) | $(12978) |
| Per share information: |  |  |
| Net loss per share of common stock - basic | $(0.29) | $(1.95) |
| Weighted average number of shares of common stock outstanding - basic | 77804612 | 6640251 |
| Net loss per share of common stock - diluted | $(0.29) | $(2.34) |
| Weighted average number of shares of common stock outstanding - diluted | 77804612 | 7700774 |

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**PLUS THERAPEUTICS, INC.**

**CONSOLIDATED STATEMENTS OF CASH FLOWS**

**(in thousands)**

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| | | |
|:---|:---|:---|
|  | **For the Years Ended December 31,** | **For the Years Ended December 31,** |
|  | **2025** | **2024** |
| **Cash flows from operating activities:** |  |  |
| Net loss | $(22386) | $(12978) |
| Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Depreciation and amortization | 445 | 872 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accretion of discount on short-term investments | (9) | (111) |
| &nbsp;&nbsp;&nbsp;&nbsp;Noncash financing expenses | 3061 | 3545 |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in fair value of derivative instruments | 2631 | (5654) |
| &nbsp;&nbsp;&nbsp;&nbsp;Stock compensation expense | 1540 | 550 |
| &nbsp;&nbsp;&nbsp;&nbsp;Gain on sale of assets | (16) |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Increases (decreases) in cash caused by changes in operating assets and liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Grant receivable | 249 | (571) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Other assets | (763) | 218 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Accounts payable and accrued expenses | (5620) | 4702 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Other liabilities | 159 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Change in operating lease liabilities | (66) | (130) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Deferred grant liability |  | (997) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net cash used in operating activities | (20775) | (10554) |
| **Cash flows from investing activities:** |  |  |
| Purchases of property and equipment | (67) | (146) |
| Proceeds from sale of property and equipment | 30 |  |
| Purchases of intangible assets |  | (545) |
| Purchases of short-term investments | (9353) | (15590) |
| Proceeds from redemption of short-term investments | 3768 |  |
| Proceeds from sales of short-term investments | 4768 | 12170 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net cash used in investing activities | (854) | (4111) |
| **Cash flows from financing activities:** |  |  |
| Principal payments of term loan obligation |  | (3996) |
| Proceeds from credit facility | 750 | 3292 |
| Repayment of credit facility | (3292) |  |
| Payment of financing costs | (2250) |  |
| Proceeds from issuance of notes payable and warrants | 3738 |  |
| Repayment of notes payable | (3703) |  |
| Proceeds from sale of common stock, pre-funded warrants, and warrants | 15926 | 7265 |
| Proceeds from sale of common stock under Lincoln Park Purchase Agreement | 22615 |  |
| Payment to investors pursuant to Letter Agreement | (3242) |  |
| Offering costs for sale of common stock | (231) |  |
| Purchase of treasury stock |  | (374) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net cash provided by financing activities | 30311 | 6187 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net increase (decrease) in cash and cash equivalents | 8682 | (8478) |
| Cash, cash equivalents, and restricted cash at beginning of period | 76 | 8554 |
| Cash, cash equivalents, and restricted cash at end of period | $8758 | $76 |
| **Supplemental disclosure of cash flows information:** |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Cash paid during period for: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Interest | $— | $32 |
| **Supplemental schedule of non-cash investing and financing activities:** |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Unpaid offering cost | $252 | $— |
| &nbsp;&nbsp;&nbsp;&nbsp;Unpaid liability to investors pursuant to Letter Agreement | $4502 | $— |
| &nbsp;&nbsp;&nbsp;&nbsp;Exchange of warrants for notes payable | $3694 | $— |
| &nbsp;&nbsp;&nbsp;&nbsp;Redemption of notes by issuance of common stock, pre-funded warrants and warrants | $3512 | $— |
| &nbsp;&nbsp;&nbsp;&nbsp;Right-of-use assets acquired by assuming operating lease liabilities | $62 | $— |

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