# EDGAR Filing Document

**Accession Number:** 0000944809
**File Stem:** 0000944809-23-000004
**Filing Date:** 2023-2
**Character Count:** 13091
**Document Hash:** 90e2af6e10344d80e8d7537b44ab0d5e
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000944809-23-000004.hdr.sgml**: 20230203

**ACCESSION NUMBER**: 0000944809-23-000004

**CONFORMED SUBMISSION TYPE**: SC 13D/A

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20230203

**DATE AS OF CHANGE**: 20230203

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** GeneDx Holdings Corp.
- **CENTRAL INDEX KEY:** 0001818331
- **STANDARD INDUSTRIAL CLASSIFICATION:** SERVICES-HEALTH SERVICES [8000]
- **IRS NUMBER:** 851966622
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13D/A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-91664
- **FILM NUMBER:** 23585878

**BUSINESS ADDRESS:**
- **STREET 1:** 333 LUDLOW STREET
- **STREET 2:** NORTH TOWER, 8TH FLOOR
- **CITY:** STAMFORD
- **STATE:** CT
- **ZIP:** 06902
- **BUSINESS PHONE:** 617 780 8742

**MAIL ADDRESS:**
- **STREET 1:** 333 LUDLOW STREET
- **STREET 2:** NORTH TOWER, 8TH FLOOR
- **CITY:** STAMFORD
- **STATE:** CT
- **ZIP:** 06902

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Sema4 Holdings Corp.
- **DATE OF NAME CHANGE:** 20210721

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** CM Life Sciences, Inc.
- **DATE OF NAME CHANGE:** 20200715
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** OPKO HEALTH, INC.
- **CENTRAL INDEX KEY:** 0000944809
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 752402409
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13D/A

**BUSINESS ADDRESS:**
- **STREET 1:** 4400 BISCAYNE BLVD.
- **CITY:** MIAMI
- **STATE:** FL
- **ZIP:** 33137
- **BUSINESS PHONE:** 305-575-4181

**MAIL ADDRESS:**
- **STREET 1:** 4400 BISCAYNE BLVD.
- **CITY:** MIAMI
- **STATE:** FL
- **ZIP:** 33137

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Opko Health, Inc.
- **DATE OF NAME CHANGE:** 20070621

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** eXegenics Inc
- **DATE OF NAME CHANGE:** 20040505

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** EXEGENICS INC
- **DATE OF NAME CHANGE:** 20011114

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549** 

**SCHEDULE 13D/A** 

**Under the Securities Exchange Act of 1934**

 **(Amendment No. 1)**

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| |
|:---|
| **GeneDx Holdings, Corp.** |
| **(Name of Issuer)** |

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| |
|:---|
| **Class A Common Stock, par value $0.0001 per share** |
| **(Title of Class of Securities)** |

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| |
|:---|
| **81663L101** |
| **(CUSIP Number)** |

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| |
|:---|
| **Steven D. Rubin <br>Executive Vice President - Administration <br>OPKO Health, Inc. <br>4400 Biscayne Boulevard <br>Miami, Florida 33137 <br>Telephone: (305) 575-4100** |
| **(Name, address and telephone number of person authorized to receive notices and communications)** |

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| |
|:---|
| **January 26, 2023** |
| **(Date of event which requires filing of this statement)** |

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If the filing person has previously filed a statement on Schedule 13G to report the acquisition which is the subject of this Schedule 13D, and is filing this schedule because of Rule 13d-1(e), Rule 13d-1(f) or Rule 13d-1(g), check the following box ◻.

**NOTE:** Schedules filed in paper format shall include a signed original and five copies of the Schedule, including all exhibits. See Rule 13d-7 for other parties to whom copies are to be sent.

\* The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be "filed" for purpose of Section 18 of the Securities Exchange Act of 1934 ("<u>Act</u>") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the *Notes*).

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| | | | |
|:---|:---|:---|:---|
| **1** | NAME OF REPORTING PERSONS<br>**OPKO Health, Inc.** | NAME OF REPORTING PERSONS<br>**OPKO Health, Inc.** | NAME OF REPORTING PERSONS<br>**OPKO Health, Inc.** |
| **2** | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP<br>(a) ◻&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ◻ | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP<br>(a) ◻&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ◻ | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP<br>(a) ◻&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ◻ |
| **3** | SEC USE ONLY | SEC USE ONLY | SEC USE ONLY |
| **4** | SOURCE OF FUNDS<br>**WC** | SOURCE OF FUNDS<br>**WC** | SOURCE OF FUNDS<br>**WC** |
| **5** | CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e) <br>☒ | CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e) <br>☒ | CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e) <br>☒ |
| **6** | CITIZENSHIP OR PLACE OF ORGANIZATION<br>**Delaware** | CITIZENSHIP OR PLACE OF ORGANIZATION<br>**Delaware** | CITIZENSHIP OR PLACE OF ORGANIZATION<br>**Delaware** |
| &nbsp;&nbsp;NUMBER OF SHARES<br>BENEFICIALLY OWNED BY<br>EACH REPORTING<br>PERSON <br>WITH | &nbsp;&nbsp;NUMBER OF SHARES<br>BENEFICIALLY OWNED BY<br>EACH REPORTING<br>PERSON <br>WITH | **7** | SOLE VOTING POWER  |
| &nbsp;&nbsp;NUMBER OF SHARES<br>BENEFICIALLY OWNED BY<br>EACH REPORTING<br>PERSON <br>WITH | &nbsp;&nbsp;NUMBER OF SHARES<br>BENEFICIALLY OWNED BY<br>EACH REPORTING<br>PERSON <br>WITH |  | 94285714 |
| &nbsp;&nbsp;NUMBER OF SHARES<br>BENEFICIALLY OWNED BY<br>EACH REPORTING<br>PERSON <br>WITH | &nbsp;&nbsp;NUMBER OF SHARES<br>BENEFICIALLY OWNED BY<br>EACH REPORTING<br>PERSON <br>WITH | **8** | SHARED VOTING POWER |
| &nbsp;&nbsp;NUMBER OF SHARES<br>BENEFICIALLY OWNED BY<br>EACH REPORTING<br>PERSON <br>WITH | &nbsp;&nbsp;NUMBER OF SHARES<br>BENEFICIALLY OWNED BY<br>EACH REPORTING<br>PERSON <br>WITH |  |  |
| &nbsp;&nbsp;NUMBER OF SHARES<br>BENEFICIALLY OWNED BY<br>EACH REPORTING<br>PERSON <br>WITH | &nbsp;&nbsp;NUMBER OF SHARES<br>BENEFICIALLY OWNED BY<br>EACH REPORTING<br>PERSON <br>WITH | **9** | SOLE DISPOSITIVE POWER |
| &nbsp;&nbsp;NUMBER OF SHARES<br>BENEFICIALLY OWNED BY<br>EACH REPORTING<br>PERSON <br>WITH | &nbsp;&nbsp;NUMBER OF SHARES<br>BENEFICIALLY OWNED BY<br>EACH REPORTING<br>PERSON <br>WITH |  | 94285714 |
| &nbsp;&nbsp;NUMBER OF SHARES<br>BENEFICIALLY OWNED BY<br>EACH REPORTING<br>PERSON <br>WITH | &nbsp;&nbsp;NUMBER OF SHARES<br>BENEFICIALLY OWNED BY<br>EACH REPORTING<br>PERSON <br>WITH | **10** | SHARED DISPOSITIVE POWER |
| &nbsp;&nbsp;NUMBER OF SHARES<br>BENEFICIALLY OWNED BY<br>EACH REPORTING<br>PERSON <br>WITH | &nbsp;&nbsp;NUMBER OF SHARES<br>BENEFICIALLY OWNED BY<br>EACH REPORTING<br>PERSON <br>WITH |  |  |
| **11** | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
|  | 94285714 | 94285714 |  |
| **12** | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES ◻ | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES ◻ | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES ◻ |
| **13** | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11) |
|  | % | <sup>(1)</sup> | <sup>(1)</sup> |
| **14** | TYPE OF REPORTING PERSON<br>**CO** | TYPE OF REPORTING PERSON<br>**CO** | TYPE OF REPORTING PERSON<br>**CO** |

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<sup>(1)&nbsp;&nbsp;&nbsp;&nbsp;</sup>Based on 810,000,334 shares of GeneDx Common Stock (as defined herein) of the Issuer (as defined herein) to be outstanding immediately after the Issuer's Offering (as defined herein) as set forth in the Issuer's Prospectus on Form 424 filed with the SEC (as defined herein) on January 30, 2023.

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**EXPLANATORY NOTE**

This Amendment No. 1 (the "<u>Amendment</u>") to Schedule 13D is being filed with the Securities and Exchange Commission (the "<u>SEC</u>") on behalf of OPKO Health, Inc., a Delaware corporation ("<u>OPKO</u>") and relates to the Class A common stock, par value $0.0001 per share ("<u>GeneDx Common Stock</u>"), of GeneDx Holdings Corp., a Delaware corporation ("<u>GeneDx</u>" or the "<u>Issuer</u>") and amends and supplements the initial statement on Schedule 13D filed by OPKO with the SEC on May 9, 2022 (the "<u>Schedule 13D</u>"). Capitalized terms used but not defined in this Amendment No. 1 shall have the same meanings ascribed to them in the Schedule 13D.

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| | |
|:---|:---|
| **ITEM 2.** | **Identity and Background.** |

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**Schedule I is hereby amended as follows:**

Jon Cohen has retired from OPKO and is therefore no longer a director and officer and the following directors and officers have been added.

**<u>Directors of OPKO</u>**

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| | | | |
|:---|:---|:---|:---|
| Name | Business Address | Principal Occupation or Employment | Citizenship |
| Elias A. Zerhouni, M.D. | c/o OPKO Health, Inc.<br>4400 Biscayne Blvd.<br>Miami, Florida 33137 | Vice Chairman of the Board and President of OPKO Health, Inc. | United States |
| Gary J. Nabel, M.D., Ph.D. | c/o OPKO Health, Inc.<br>4400 Biscayne Blvd.<br>Miami, Florida 33137 | Chief Innovation Officer of OPKO Health Inc. | United States |
| Alexis Borisy | c/o OPKO Health, Inc.<br>4400 Biscayne Blvd.<br>Miami, Florida 33137 | Executive Chairman of the Board of EQRx, Inc. | United States |

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**<u>Officers of OPKO</u>**

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| | | | |
|:---|:---|:---|:---|
| Name | Business Address | Principal Occupation or Employment | Citizenship |
| Elias A. Zerhouni, M.D. | c/o OPKO Health, Inc.<br>4400 Biscayne Blvd.<br>Miami, Florida 33137 | President and Vice Chairman of the Board | United States |
| Gary J. Nabel, M.D., Ph.D. | c/o OPKO Health, Inc.<br>4400 Biscayne Blvd.<br>Miami, Florida 33137 | Chief Innovation Officer | United States |

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| | |
|:---|:---|
| **ITEM 3.** | **Source and Amount of Funds or Other Consideration.** |

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**Item 3 is amended by adding the following paragraph to the end of the item:**

On January 26, 2023, OPKO acquired 14,285,714 shares of GeneDx Common Stock in a registered public offering (the "<u>Offering</u>") at $0.35 per shares for an aggregate purchase price of approximately $5,000,000. The source of funds used to acquire the GeneDx Common Stock was working capital of OPKO.

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| | |
|:---|:---|
| **ITEM 4.** | **Purpose of Transaction.** |

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**Item 4 is amended by adding the following paragraph to the end of the item:**

On January 26, 2023, OPKO acquired 14,285,714 shares of GeneDx Common Stock in the Offering at $0.35 per shares for an aggregate purchase price of approximately $5,000,000.

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| | |
|:---|:---|
| **ITEM 5.** | **Interest in Securities of the Issuer.** |

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**Item 5 is deleted in its entirety and replaced with the following text:**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;&nbsp;&nbsp;&nbsp;The Company's beneficial ownership of Sema4 Common Stock is as set forth in the table below:

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| | | |
|:---|:---|:---|
| **Name and Title of Beneficial Owner** | **Number of Outstanding Shares Beneficially Owned** | **Percentage of Outstanding Common Shares** <sup>(1)</sup> |
| OPKO Health, Inc. | 94285714 | 11.6% |

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______________

<sup>(1)&nbsp;&nbsp;&nbsp;&nbsp;</sup>Based on 810,000,334 shares of GeneDx Common Stock outstanding immediately after the Offering, as set forth in the Issuer's Prospectus on Form 424 filed with the SEC on January 30, 2023.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;&nbsp;&nbsp;&nbsp;Items 7-10, inclusive, set forth on the cover page to this Amendment are hereby incorporated by reference in this Item 5.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;&nbsp;&nbsp;&nbsp;The information contained in Item 3 of this Amendment is incorporated by reference in this Item 5. Except as stated herein, OPKO has not effected any transactions in the shares of GeneDx Common Stock within the last 60 days.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;&nbsp;&nbsp;&nbsp;Except as described herein, no other person is known by OPKO to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, any shares of the Issuer beneficially owned by them.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e)&nbsp;&nbsp;&nbsp;&nbsp;Not applicable.

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**SIGNATURES** 

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

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| | | |
|:---|:---|:---|
| | **OPKO Health, Inc.** | **OPKO Health, Inc.** |
| | By: | /s/ Steven D. Rubin |
| Date: February 3, 2023 | Name: | Steven D. Rubin |
|  | Title: | Executive Vice President-Administration |

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