# EDGAR Filing Document

**Accession Number:** 0001819113
**File Stem:** 0001104659-23-028753
**Filing Date:** 2023-3
**Character Count:** 2179
**Document Hash:** 2eeb9a20f1a0a5d4a5339c6bbba318bb
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-23-028753.hdr.sgml**: 20230411

**ACCESSION NUMBER**: 0001104659-23-028753

**CONFORMED SUBMISSION TYPE**: CORRESP

**PUBLIC DOCUMENT COUNT**: 3

**FILED AS OF DATE**: 20230306

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Science 37 Holdings, Inc.
- **CENTRAL INDEX KEY:** 0001819113
- **STANDARD INDUSTRIAL CLASSIFICATION:** SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
- **IRS NUMBER:** 844278203
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** CORRESP

**BUSINESS ADDRESS:**
- **STREET 1:** 800 PARK OFFICES DRIVE
- **STREET 2:** SUITE 3606
- **CITY:** RESEARCH TRIANGLE PARK
- **STATE:** NC
- **ZIP:** 27709
- **BUSINESS PHONE:** (984) 377-3737

**MAIL ADDRESS:**
- **STREET 1:** 800 PARK OFFICES DRIVE
- **STREET 2:** SUITE 3606
- **CITY:** RESEARCH TRIANGLE PARK
- **STATE:** NC
- **ZIP:** 27709

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Lifesci Acquisition II Corp.
- **DATE OF NAME CHANGE:** 20200723

![](tm238406d2_correspimg001.jpg)

March 6, 2023

Via EDGAR

United States Securities and Exchange Commission<br> Division of Corporation Finance<br> 100 F. Street, N.E. <br> Washington, D.C. 20549

Re: Science 37 Holdings, Inc. – Registration Statement on Form S-3

Ladies and Gentlemen,

Attached please find the Registration Statement on Form S-3 filed by Science 37 Holdings, Inc. (the "Company") in connection with "shelf" registration for the proposed offering from time to time on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, as amended, of the securities described in the prospectus to the Registration Statement on Form S-3.

If you have any questions or comments regarding this filing, please call me at (330) 819-1221 or contact me via e-mail at <u>Jurgita.Ashley@ThompsonHine.com</u>. We would appreciate if you could please advise us once your review is completed.

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| |
|:---|
| Respectfully, |
| /s/ Jurgita Ashley |
| Jurgita Ashley |

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cc: Christine Pellizzari, Science 37 Holdings, Inc. (<u>Christine.Pellizzari@science37.com</u>; 984-377-3737)

![](tm238406d2_correspimg002.jpg)