# EDGAR Filing Document

**Accession Number:** 0001791827
**File Stem:** 0001791827-23-000002
**Filing Date:** 2023-2
**Character Count:** 12771
**Document Hash:** 90d88016fd081bdaa6bc808fccf8469c
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001791827-23-000002.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001791827-23-000002

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**EFFECTIVENESS DATE**: 20230214

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Avidity Partners Management LP
- **CENTRAL INDEX KEY:** 0001791827
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-20028
- **FILM NUMBER:** 23630493

**BUSINESS ADDRESS:**
- **STREET 1:** 2828 N HARWOOD STREET
- **STREET 2:** SUITE 1220
- **CITY:** DALLAS
- **STATE:** TX
- **ZIP:** 75201
- **BUSINESS PHONE:** 214-550-1822

**MAIL ADDRESS:**
- **STREET 1:** 2828 N HARWOOD STREET
- **STREET 2:** SUITE 1220
- **CITY:** DALLAS
- **STATE:** TX
- **ZIP:** 75201

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2022

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** Avidity Partners Management LP<br>**Address:** 2828 N HARWOOD STREET<br>SUITE 1220<br>DALLAS, TX 75201

**Form 13F File Number:** 028-20028

**CRD Number (if applicable):** 000304628

**SEC File Number (if applicable):** 801-118809

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Delmer Dee Raibourn III<br>**Title:** Chief Compliance Officer<br>**Phone:** 214-550-1934

**Signature, Place, and Date of Signing:**

/S/ Delmer Dee Raibourn III  Dallas, TX  02-14-2023<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 85

**Form 13F Information Table Value Total:** $4615991045

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| AC IMMUNE SA | SHS | H00263105 |  | 663816 | 325400 | SH |  | SOLE | 0 | 325400 | 0 | 0 |
| ACADIA HEALTHCARE COMPANY IN | COM | 00404A109 |  | 95902800 | 1165000 | SH |  | SOLE | 0 | 1165000 | 0 | 0 |
| AKERO THERAPEUTICS INC | COM | 00973Y108 |  | 209610000 | 3825000 | SH |  | SOLE | 0 | 3825000 | 0 | 0 |
| ALPINE IMMUNE SCIENCES INC | COM | 02083G100 |  | 7557270 | 1028200 | SH |  | SOLE | 0 | 1028200 | 0 | 0 |
| ALTIMMUNE INC | COM NEW | 02155H200 |  | 65635500 | 3990000 | SH |  | SOLE | 0 | 3990000 | 0 | 0 |
| AN2 THERAPEUTICS INC | COM | 037326105 |  | 7086508 | 743600 | SH |  | SOLE | 0 | 743600 | 0 | 0 |
| ARCUTIS BIOTHERAPEUTICS INC | COM | 03969K108 |  | 25974000 | 1755000 | SH |  | SOLE | 0 | 1755000 | 0 | 0 |
| ARGENX SE | SPONSORED ADR | 04016X101 |  | 236768750 | 625000 | SH |  | SOLE | 0 | 625000 | 0 | 0 |
| ARROWHEAD PHARMACEUTICALS IN | COM | 04280A100 |  | 55770000 | 1375000 | SH |  | SOLE | 0 | 1375000 | 0 | 0 |
| ARVINAS INC | COM | 04335A105 |  | 169339500 | 4950000 | SH |  | SOLE | 0 | 4950000 | 0 | 0 |
| ARYA SCIENCES ACQU CORP IV | CL A | G31659108 |  | 5050000 | 500000 | SH |  | SOLE | 0 | 500000 | 0 | 0 |
| ASTRAZENECA PLC | SPONSORED ADR | 046353108 |  | 81360000 | 1200000 | SH |  | SOLE | 0 | 1200000 | 0 | 0 |
| AVIDITY BIOSCIENCES INC | COM | 05370A108 |  | 72672250 | 3275000 | SH |  | SOLE | 0 | 3275000 | 0 | 0 |
| AXSOME THERAPEUTICS INC | COM | 05464T104 |  | 51677100 | 670000 | SH |  | SOLE | 0 | 670000 | 0 | 0 |
| BELLUS HEALTH INC NEW | COM NEW | 07987C204 |  | 37811984 | 4599998 | SH |  | SOLE | 0 | 4599998 | 0 | 0 |
| BIO RAD LABS INC | CL A | 090572207 |  | 38769178 | 92200 | SH |  | SOLE | 0 | 92200 | 0 | 0 |
| BIOATLA INC | COM | 09077B104 |  | 10395000 | 1260000 | SH |  | SOLE | 0 | 1260000 | 0 | 0 |
| BIOHAVEN LTD | COM | G1110E107 |  | 20708960 | 1492000 | SH |  | SOLE | 0 | 1492000 | 0 | 0 |
| BIONTECH SE | SPONSORED ADS | 09075V102 |  | 32357388 | 215400 | SH |  | SOLE | 0 | 215400 | 0 | 0 |
| BOSTON SCIENTIFIC CORP | COM | 101137107 |  | 150687509 | 3256700 | SH |  | SOLE | 0 | 3256700 | 0 | 0 |
| CAREMAX INC | COM CL A | 14171W103 |  | 2756951 | 755329 | SH |  | SOLE | 0 | 755329 | 0 | 0 |
| CARIBOU BIOSCIENCES INC | COM | 142038108 |  | 18102728 | 2882600 | SH |  | SOLE | 0 | 2882600 | 0 | 0 |
| CENTURY THERAPEUTICS INC | COM | 15673T100 |  | 6687468 | 1303600 | SH |  | SOLE | 0 | 1303600 | 0 | 0 |
| COLLEGIUM PHARMACEUTICAL INC | COM | 19459J104 |  | 879234 | 37898 | SH |  | SOLE | 0 | 37898 | 0 | 0 |
| COMPASS THERAPEUTICS INC | COM | 20454B104 |  | 10060000 | 2000000 | SH |  | SOLE | 0 | 2000000 | 0 | 0 |
| CYTEIR THERAPEUTICS INC | COM | 23284P103 |  | 2963070 | 1795800 | SH |  | SOLE | 0 | 1795800 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 19276474 | 420700 | SH |  | SOLE | 0 | 420700 | 0 | 0 |
| DECIPHERA PHARMACEUTICALS IN | COM | 24344T101 |  | 18455140 | 1126000 | SH |  | SOLE | 0 | 1126000 | 0 | 0 |
| DEXCOM INC | COM | 252131107 |  | 85700032 | 756800 | SH |  | SOLE | 0 | 756800 | 0 | 0 |
| ESSA PHARMA INC | COM NEW | 29668H708 |  | 4675608 | 1855400 | SH |  | SOLE | 0 | 1855400 | 0 | 0 |
| FATE THERAPEUTICS INC | COM | 31189P102 |  | 1055949 | 104653 | SH |  | SOLE | 0 | 104653 | 0 | 0 |
| GRAPHITE BIO INC | COM | 38870X104 |  | 5229000 | 1575000 | SH |  | SOLE | 0 | 1575000 | 0 | 0 |
| HEALTH SCIENCES ACQ CORP 2 | ORD SHS | G4411D109 |  | 3992000 | 400000 | SH |  | SOLE | 0 | 400000 | 0 | 0 |
| HYPERFINE INC | COM CL A | 44916K106 |  | 1263153 | 1503754 | SH |  | SOLE | 0 | 1503754 | 0 | 0 |
| ICON PLC | SHS | G4705A100 |  | 41763750 | 215000 | SH |  | SOLE | 0 | 215000 | 0 | 0 |
| IDEAYA BIOSCIENCES INC | COM | 45166A102 |  | 69496616 | 3824800 | SH |  | SOLE | 0 | 3824800 | 0 | 0 |
| IMMUNOCORE HLDGS PLC | ADS | 45258D105 |  | 65858780 | 1154000 | SH |  | SOLE | 0 | 1154000 | 0 | 0 |
| INTELLIA THERAPEUTICS INC | COM | 45826J105 |  | 22266798 | 638200 | SH |  | SOLE | 0 | 638200 | 0 | 0 |
| INTRA-CELLULAR THERAPIES INC | COM | 46116X101 |  | 26671680 | 504000 | SH |  | SOLE | 0 | 504000 | 0 | 0 |
| IVERIC BIO INC | COM | 46583P102 |  | 17950294 | 838407 | SH |  | SOLE | 0 | 838407 | 0 | 0 |
| JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 |  | 115904557 | 727541 | SH |  | SOLE | 0 | 727541 | 0 | 0 |
| KARUNA THERAPEUTICS INC | COM | 48576A100 |  | 58753500 | 299000 | SH |  | SOLE | 0 | 299000 | 0 | 0 |
| KARYOPHARM THERAPEUTICS INC | COM | 48576U106 |  | 32755297 | 9633911 | SH |  | SOLE | 0 | 9633911 | 0 | 0 |
| KEZAR LIFE SCIENCES INC | COM | 49372L100 |  | 47748096 | 6782400 | SH |  | SOLE | 0 | 6782400 | 0 | 0 |
| KINNATE BIOPHARMA INC | COM | 49705R105 |  | 7397470 | 1212700 | SH |  | SOLE | 0 | 1212700 | 0 | 0 |
| LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 |  | 48422400 | 970000 | SH |  | SOLE | 0 | 970000 | 0 | 0 |
| LILLY ELI  CO | COM | 532457108 |  | 79387280 | 217000 | SH |  | SOLE | 0 | 217000 | 0 | 0 |
| MADRIGAL PHARMACEUTICALS INC | COM | 558868105 |  | 124807500 | 430000 | SH |  | SOLE | 0 | 430000 | 0 | 0 |
| MEDICUS SCIENCES ACQUISITION | CL A SHS | G5960S108 |  | 5236400 | 520000 | SH |  | SOLE | 0 | 520000 | 0 | 0 |
| MEDICUS SCIENCES ACQUISITION | *W EXP 02/12/202 | G5960S124 |  | 5199 | 57770 | SH |  | SOLE | 0 | 57770 | 0 | 0 |
| NANOSTRING TECHNOLOGIES INC | COM | 63009R109 |  | 16395884 | 2057200 | SH |  | SOLE | 0 | 2057200 | 0 | 0 |
| NATERA INC | COM | 632307104 |  | 72261813 | 1798900 | SH |  | SOLE | 0 | 1798900 | 0 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 |  | 212603200 | 1780000 | SH |  | SOLE | 0 | 1780000 | 0 | 0 |
| NUVATION BIO INC | *W EXP 07/07/202 | 67080N119 |  | 14450 | 99999 | SH |  | SOLE | 0 | 99999 | 0 | 0 |
| PANACEA ACQUISITION CORP II | CL A SHS | G6882C106 |  | 5025000 | 500000 | SH |  | SOLE | 0 | 500000 | 0 | 0 |
| PHATHOM PHARMACEUTICALS INC | COM | 71722W107 |  | 21318000 | 1900000 | SH |  | SOLE | 0 | 1900000 | 0 | 0 |
| PLIANT THERAPEUTICS INC | COM | 729139105 |  | 43306932 | 2240400 | SH |  | SOLE | 0 | 2240400 | 0 | 0 |
| POINT BIOPHARMA GLOBAL INC | COM | 730541109 |  | 17732196 | 2432400 | SH |  | SOLE | 0 | 2432400 | 0 | 0 |
| PROMETHEUS BIOSCIENCES INC | COM | 74349U108 |  | 22440000 | 204000 | SH |  | SOLE | 0 | 204000 | 0 | 0 |
| PROTHENA CORP PLC | SHS | G72800108 |  | 177918250 | 2953000 | SH |  | SOLE | 0 | 2953000 | 0 | 0 |
| QUEST DIAGNOSTICS INC | COM | 74834L100 |  | 40361520 | 258000 | SH |  | SOLE | 0 | 258000 | 0 | 0 |
| REUNION NEUROSCIENCE INC | COM | 76134G103 |  | 504270 | 560300 | SH |  | SOLE | 0 | 560300 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 58954500 | 2475000 | SH |  | SOLE | 0 | 2475000 | 0 | 0 |
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 |  | 29885093 | 1527087 | SH |  | SOLE | 0 | 1527087 | 0 | 0 |
| SANGAMO THERAPEUTICS INC | COM | 800677106 |  | 8629662 | 2748300 | SH |  | SOLE | 0 | 2748300 | 0 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607100 |  | 136706900 | 1055000 | SH |  | SOLE | 0 | 1055000 | 0 | 0 |
| SCYNEXIS INC | COM NEW | 811292200 |  | 1779336 | 1140600 | SH |  | SOLE | 0 | 1140600 | 0 | 0 |
| SOCIAL CAP SUVRETTA HLDS CP | CLASS A ORD SHS | G8253Y105 |  | 2010000 | 200000 | SH |  | SOLE | 0 | 200000 | 0 | 0 |
| SOCIAL CAP SUVRETTA HLDS CRP | CLASS A ORD SHS | G8253U103 |  | 2012000 | 200000 | SH |  | SOLE | 0 | 200000 | 0 | 0 |
| SPDR SER TR | S BIOTECH | 78464A870 |  | 337146000 | 4062000 | SH | Call | SOLE | 0 | 4062000 | 0 | 0 |
| SURGERY PARTNERS INC | COM | 86881A100 |  | 86700320 | 3112000 | SH |  | SOLE | 0 | 3112000 | 0 | 0 |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 |  | 149162450 | 5861000 | SH |  | SOLE | 0 | 5861000 | 0 | 0 |
| SYROS PHARMACEUTICALS INC | COM NEW | 87184Q206 |  | 3231000 | 900000 | SH |  | SOLE | 0 | 900000 | 0 | 0 |
| TENET HEALTHCARE CORP | COM NEW | 88033G407 |  | 34997067 | 717300 | SH |  | SOLE | 0 | 717300 | 0 | 0 |
| TWIST BIOSCIENCE CORP | COM | 90184D100 |  | 14547910 | 611000 | SH |  | SOLE | 0 | 611000 | 0 | 0 |
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 |  | 138526700 | 2990000 | SH |  | SOLE | 0 | 2990000 | 0 | 0 |
| UNITED THERAPEUTICS CORP DEL | COM | 91307C102 |  | 218439695 | 785500 | SH |  | SOLE | 0 | 785500 | 0 | 0 |
| UNIVERSAL HLTH SVCS INC | CL B | 913903100 |  | 116318784 | 825600 | SH |  | SOLE | 0 | 825600 | 0 | 0 |
| VAXCYTE INC | COM | 92243G108 |  | 77458430 | 1615400 | SH |  | SOLE | 0 | 1615400 | 0 | 0 |
| VENTYX BIOSCIENCES INC | COM | 92332V107 |  | 42135150 | 1285000 | SH |  | SOLE | 0 | 1285000 | 0 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 |  | 49670160 | 172000 | SH |  | SOLE | 0 | 172000 | 0 | 0 |
| VERVE THERAPEUTICS INC | COM | 92539P101 |  | 30282750 | 1565000 | SH |  | SOLE | 0 | 1565000 | 0 | 0 |
| VIR BIOTECHNOLOGY INC | COM | 92764N102 |  | 21513500 | 850000 | SH |  | SOLE | 0 | 850000 | 0 | 0 |
| ZAI LAB LTD | ADR | 98887Q104 |  | 961186 | 31309 | SH |  | SOLE | 0 | 31309 | 0 | 0 |
| ZENTALIS PHARMACEUTICALS INC | COM | 98943L107 |  | 103721000 | 5150000 | SH |  | SOLE | 0 | 5150000 | 0 | 0 |

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