# EDGAR Filing Document

**Accession Number:** 0000812796
**File Stem:** 0001558370-25-008774
**Filing Date:** 2025-6
**Character Count:** 32770
**Document Hash:** afabef7780dee1c998195130eb7a99c9
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001558370-25-008774.hdr.sgml**: 20250620

**ACCESSION NUMBER**: 0001558370-25-008774

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 6

**FILED AS OF DATE**: 20250620

**DATE AS OF CHANGE**: 20250620

**EFFECTIVENESS DATE**: 20250620

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** SOLIGENIX, INC.
- **CENTRAL INDEX KEY:** 0000812796
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 411505029
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-288190
- **FILM NUMBER:** 251061480

**BUSINESS ADDRESS:**
- **STREET 1:** 29 EMMONS DRIVE
- **STREET 2:** SUITE B-10
- **CITY:** PRINCETON
- **STATE:** NJ
- **ZIP:** 08540
- **BUSINESS PHONE:** 609-538-8200

**MAIL ADDRESS:**
- **STREET 1:** 29 EMMONS DRIVE
- **STREET 2:** SUITE B-10
- **CITY:** PRINCETON
- **STATE:** NJ
- **ZIP:** 08540

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** DOR BIOPHARMA INC
- **DATE OF NAME CHANGE:** 20020329

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ENDOREX CORP
- **DATE OF NAME CHANGE:** 19960916

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** IMMUNOTHERAPEUTICS INC
- **DATE OF NAME CHANGE:** 19920703

**As filed with the Securities and Exchange Commission on June 20, 2025.**

**Registration No. 333-_____**

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**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**WASHINGTON, D.C. 20549**

**FORM S-8**

**REGISTRATION STATEMENT**

**UNDER**

**THE SECURITIES ACT OF 1933**

**SOLIGENIX, INC.**

*(Exact name of registrant as specified in its charter)*

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| | | |
|:---|:---|:---|
| **Delaware** |  | **41-1505029** |
| *(State or other jurisdiction of*<br>*incorporation or organization)* |  | *(I.R.S. Employer* <br>*Identification No.)* |

---

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| | | |
|:---|:---|:---|
| **29 Emmons Drive, Suite B-10**<br>**Princeton, New Jersey** |  | **08540** |
| *(Address of Principal Executive Offices)* |  | *(Zip Code)* |

---

**Soligenix, Inc. 2025 Equity Incentive Plan**

*(Full title of the plan)*

**Christopher J. Schaber, Ph.D.**

**President and Chief Executive Officer**

**Soligenix, Inc.**

**29 Emmons Drive, Suite B-10**

**Princeton, New Jersey 08540**

 *(Name and address of agent for service)*

**(609) 538-8200**

*(Telephone number, including area code, of agent for service)*

*with copies to:*

**Driscoll R. Ugarte, Esq.**

**Duane Morris LLP**

**5100 Town Center Circle, Suite 400**

**Boca Raton, FL 33486-1008**

**(561) 962-2100**

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.

Large accelerated filer ☐ Accelerated filer ☐ <br> Non-accelerated filer ☑ Smaller reporting company ☑ <br> Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period to comply with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of Securities Act. ☐

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#### PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS

#### Item 1. Plan Information\*

#### Item 2. Registrant Information and Employee Plan Annual Information\*
\*The information specified in Item 1 and Item 2 of Part I of this Registration Statement on Form S-8 (this "Registration Statement") is omitted from this filing in accordance with the provisions of Rule 428 under the Securities Act of 1933, as amended (the "Securities Act"), and the introductory note to Part I of Form S-8. The documents containing the information specified in Part I will be delivered to the participants in the Soligenix, Inc. 2025 Equity Incentive Plan (hereinafter referred to as the "Plan") as required by Rule 428. Such documents and the documents incorporated by reference in this Registration Statement pursuant to Item 3 of Part II of this Registration Statement, taken together, constitute a prospectus that meets the requirements of Section 10(a) of the Securities Act.

#### PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

#### Item 3. Incorporation of Documents by Reference.
The Securities and Exchange Commission (the "Commission") allows us to "incorporate by reference" the information we file with it, which means that we can disclose important information to you by referring you to those documents instead of having to repeat the information in this prospectus. The information incorporated by reference is considered to be part of this prospectus, and later information that we file with the Commission will automatically update and supersede this information. We incorporate by reference the documents listed below and any future filings made with the Commission under Sections 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), between the date of this prospectus and the termination of the offering:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) [Our Annual Report on Form 10-K for the fiscal year ended December 31, 2024, filed with the Commission on March 21, 2025;](https://www.sec.gov/ix?doc=/Archives/edgar/data/812796/000155837025003459/sngx-20241231x10k.htm)

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) [Our Quarterly Report on Form 10-Q for the fiscal quarter March 31, 2025, filed with the Commission on May 9, 2025;](https://www.sec.gov/ix?doc=/Archives/edgar/data/812796/000155837025007171/sngx-20250331x10q.htm)

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3) Our Current Reports on Form 8-K, filed with the Commission on [February 10, 2025](https://www.sec.gov/ix?doc=/Archives/edgar/data/812796/000155837025000726/sngx-20250205x8k.htm) , [March 28, 2025](https://www.sec.gov/ix?doc=/Archives/edgar/data/812796/000155837025003987/sngx-20250325x8k.htm) and [June 20, 2025](https://www.sec.gov/ix?doc=/Archives/edgar/data/812796/000155837025008772/sngx-20250620x8k.htm) ;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(4) The Description of Securities filed as [Exhibit 4.1](https://www.sec.gov/Archives/edgar/data/812796/000155837025003459/sngx-20241231xex4d1.htm) to our Annual Report on Form 10-K for the fiscal year ended December 31, 2024, filed with the Commission on March 21, 2025; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(5) The description of our common stock, par value $0.001 per share, contained in our [Registration Statement on Form 8-A, filed with the SEC on December 12, 2016](https://www.sec.gov/Archives/edgar/data/812796/000121390016019332/f8a12b120516_soligenixinc.htm) and under the caption "Description of Capital Stock" in our prospectus, dated as of December 12, 2016, forming a part of the Registration Statement on Form S-1 (Registration No. 333-214038) filed with the SEC, including any amendments or reports filed for the purpose of updating such description.

All other reports and documents subsequently filed by us pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act (other than Current Reports furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits furnished on such form that relate to such items) shall be deemed to be incorporated by reference in this Registration Statement and to be a part of this Registration Statement from the respective date of filing of each of those reports or documents until the filing of a post-effective amendment to this Registration Statement which indicates either that all securities offered by this

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Registration Statement have been sold or which deregisters all of the securities under this Registration Statement then remaining unsold.

Any statement contained in this Registration Statement or in a document incorporated or deemed to be incorporated by reference in this Registration Statement shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained in this Registration Statement or in any other subsequently filed document which also is or is deemed to be incorporated by reference in this Registration Statement modifies or supersedes that statement. Any statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.

#### Item 4. Description of Securities.
Not applicable.

#### Item 5. Interests of Named Experts and Counsel.
Not applicable.

#### Item 6. Indemnification of Directors and Officers.
Section 145(a) of the Delaware General Corporation Law provides, in general, that a corporation may indemnify any person who was or is a party or is threatened to be made a party to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action by or in the right of the corporation), because he or she is or was a director, officer, employee or agent of the corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise, against expenses (including attorneys' fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by the person in connection with such action, suit or proceeding, if he or she acted in good faith and in a manner he or she reasonably believed to be in or not opposed to the best interests of the corporation and, with respect to any criminal action or proceeding, had no reasonable cause to believe his or her conduct was unlawful.

Section 145(b) of the Delaware General Corporation Law provides, in general, that a corporation may indemnify any person who was or is a party or is threatened to be made a party to any threatened, pending or completed action or suit by or in the right of the corporation to procure a judgment in its favor because the person is or was a director, officer, employee or agent of the corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise, against expenses (including attorneys' fees) actually and reasonably incurred by the person in connection with the defense or settlement of such action or suit if he or she acted in good faith and in a manner he or she reasonably believed to be in or not opposed to the best interests of the corporation, except that no indemnification shall be made with respect to any claim, issue or matter as to which he or she shall have been adjudged to be liable to the corporation unless and only to the extent that the Court of Chancery or other adjudicating court determines that, despite the adjudication of liability but in view of all of the circumstances of the case, he or she is fairly and reasonably entitled to indemnity for such expenses which the Court of Chancery or other adjudicating court shall deem proper.

Section 145(g) of the Delaware General Corporation Law provides, in general, that a corporation may purchase and maintain insurance on behalf of any person who is or was a director, officer, employee or agent of the corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise against any liability asserted against such person and incurred by such person in any such capacity, or arising out of his or her status as such, whether or not the corporation would have the power to indemnify the person against such liability under Section 145 of the Delaware General Corporation Law.

Section 102(b)(7) of the Delaware General Corporation Law grants a corporation the power to limit the personal liability of its directors to the corporation or its stockholders for monetary damages for breach of a fiduciary duty.

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Article IX of our Certificate of Incorporation, as amended, provides for the limitation of personal liability of the directors as follows:

"A Director of the Corporation shall have no personal liability to the corporation or its stockholders for monetary damages for breach of his fiduciary duty as a Director; provided, however, this Article shall not eliminate or limit the liability of a Director (i) for any breach of the Director's duty of loyalty to the Corporation or its stockholders; (ii) for acts or omissions not in good faith or which involve intentional misconduct or a knowing violation of law; (iii) for the unlawful payment of dividends or unlawful stock repurchases under Section 174 of the General Corporation Law of the State of Delaware; or (iv) for any transaction from which the Director derived an improper personal benefit. If the General Corporation Law is amended after approval by the stockholders of this Article to authorize corporate action further eliminating or limiting the personal liability of directors, then the liability of a director of the Corporation shall be eliminated or limited to the fullest extent permitted by the General Corporation Law of the State of Delaware, as so amended."

Article VIII of our Bylaws, as amended and restated, provide for indemnification of directors and officers to the fullest extent permitted by Section 145 of the Delaware General Corporation Law.

We have a directors' and officers' liability insurance policy.

The above discussion is qualified in its entirety by reference to our Certificate of Incorporation and Bylaws.

#### Item 7. Exemption from Registration Claimed.
Not applicable.

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#### Item 8. Exhibits.

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| | |
|:---|:---|
| Exhibit<br>Number | Description |
| 4.1 | [Second Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 included in the Registrant's Current Report on Form 8-K filed on June 22, 2012).](https://www.sec.gov/Archives/edgar/data/812796/000121390012003441/f8k062112ex3i_soligenix.htm) |
| 4.2 | [Amended and Restated Bylaws (incorporated by reference to Exhibit 3.1 included in the Registrant's Quarterly Report on Form 10-QSB, as amended, for the fiscal quarter ended June 30, 2003).](https://www.sec.gov/Archives/edgar/data/812796/000095013703004369/c78859sbexv3w1.txt) |
| 4.3 | [Certificate of Amendment to Second Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 included in the Registrant's Current Report on Form 8-K filed on June 22, 2016).](https://www.sec.gov/Archives/edgar/data/812796/000121390016014431/f8k061616ex3i_soligenix.htm) |
| 4.4 | [Certificate of Amendment to Second Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 included in the Registrant's Current Report on Form 8-K filed on October 7, 2016).](https://www.sec.gov/Archives/edgar/data/812796/000121390016017367/f8k100716ex3i_soligenixinc.htm) |
| 4.5 | [Certificate of Amendment to Second Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 included in the Registrant's Current Report on Form 8-K filed on June 14, 2017).](https://www.sec.gov/Archives/edgar/data/812796/000121390017006494/f8k060817ex3i_soligenixinc.htm) |
| 4.6 | [Certificate of Amendment to Second Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 of the Registrant's Current Report on Form 8-K filed on September 28, 2018).](https://www.sec.gov/Archives/edgar/data/812796/000121390018013207/f8k092718ex3-1_soligenixinc.htm) |
| 4.7 | [Certificate of Amendment to Second Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 of Amendment Number 1 to the Registrant's Current Report on Form 8-K filed on December 3, 2020).](https://www.sec.gov/Archives/edgar/data/812796/000121390020040767/ea130873ex3-1_soligenix.htm) |
| 4.8 | [Amendment to Amended and Restated By-laws (incorporated by reference to Exhibit 3.1 included in the Registrant's Quarterly Report on Form 10-Q for the fiscal quarter ended March 31, 2020).](https://www.sec.gov/Archives/edgar/data/812796/000121390020012580/f10q0320ex3-1_soligenixinc.htm) |
| 4.9 | [Certificate of Designation of the Series D Preferred Stock of the Company dated December 27, 2022 (incorporated by reference to Exhibit 3.1 to our registration statement on Form 8-A filed on December 27, 2022).](https://www.sec.gov/Archives/edgar/data/812796/000155837022018984/tmb-20221223xex3d1.htm) |
| 4.10 | [Certificate of Amendment to Second Amended and Restated Certificate of Incorporation of Soligenix, Inc. (incorporated by reference to Exhibit 3.1 included in our current report on Form 8-K filed on February 9, 2023).](https://www.sec.gov/Archives/edgar/data/812796/000155837023001056/tmb-20230208xex3d1.htm) |
| 4.11 | [Certificate of Amendment to Second Amended and Restated Certificate of Incorporation of Soligenix, Inc. (incorporated by reference to Exhibit 3.1 included in our current report on Form 8-K filed on May 31, 2024).](https://www.sec.gov/Archives/edgar/data/812796/000155837024008803/sngx-20240530xex3d1.htm) |
| 5.1 | [Opinion of Duane Morris LLP regarding legality of securities being registered. \*](sngx-20250620xex5d1.htm) |
| 23.1 | [Consent of Cherry Bekaert LLP. \*](sngx-20250620xex23d1.htm) |
| 23.2 | [Consent of Duane Morris LLP (included in Exhibit 5.1 to this Registration Statement). \*](sngx-20250620xex5d1.htm) |
| 24.1 | [Power of Attorney (included on signature page of this Registration Statement). \*](#POWEROFATTORNEY_589992) |
| 99.1 | [Soligenix, Inc. 2025 Equity Incentive Plan (incorporated by reference to Exhibit 10.1 included in the Registrant's Current Report on Form 8-K filed on June 20, 2025).](https://www.sec.gov/Archives/edgar/data/812796/000155837025008772/sngx-20250620xex10d1.htm) |
| 107 | [Calculation of Filing Fee Table. \*](sngx-20250620xexfees.htm) |

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\* Filed herewith.

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#### Item 9. Undertakings.
(a)The Registrant hereby undertakes:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1)To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)To include any prospectus required by Section 10(a)(3) of the Securities Act;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)To reflect in the prospectus any facts or events arising after the effective date of this Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this Registration Statement; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)To include any material information with respect to the plan of distribution not previously disclosed in this Registration Statement or any material change to such information in this Registration Statement;

provided, however, that paragraphs (i) and (ii) shall not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to section 13 or section 15(d) of the Securities Exchange Act that are incorporated by reference in this Registration Statement;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2)That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3)To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

(b)The Registrant hereby further undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's Annual Report pursuant to Section 13(a) or Section 15(d) of the Exchange Act that is incorporated by reference in the Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

(c)Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.

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#### SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Princeton, State of New Jersey, on this 20<sup>th</sup> day of June, 2025.

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| | |
|:---|:---|
| **SOLIGENIX, INC.** | **SOLIGENIX, INC.** |
| By: | */s/ Christopher J. Schaber* |
|  | Christopher J. Schaber |
|  | Chief Executive Officer and President |

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#### POWER OF ATTORNEY
KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Christopher J. Schaber and Jonathan Guarino, and each of them, his or her true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead in any and all capacities, to sign any or all amendments to this Registration Statement on Form S-8 (including post-effective amendments), and to file the same, with all exhibits thereto, and other documents in connection therewith with the United States Securities and Exchange Commission, granting unto said attorneys-in-fact and agents full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully and to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming that said attorneys-in-fact and agents, or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, this Registration Statement on Form S-8 has been signed by the following persons in the capacities and on the dates indicated.

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| | | | |
|:---|:---|:---|:---|
| **Signature** | **Signature** | **Title** | **Date** |
| By: | */s/ Christopher J. Schaber* | Chairman, President and Chief  |  |
|  | Christopher J. Schaber, PhD | Executive Officer (Principal Executive Officer) | June 20, 2025  |
| By: | */s/ Gregg A. Lapointe* | Director |  |
|  | Gregg A. Lapointe, CPA. |  | June 20, 2025 |
| By: | */s/ Diane L. Parks* | Director |  |
|  | Diane L. Parks, MBA |  | June 20, 2025 |
| By: | */s/ Robert J. Rubin* | Director |  |
|  | Robert J. Rubin, MD |  | June 20, 2025 |
| By: | */s/ Jerome B. Zeldis* | Director |  |
|  | Jerome B. Zeldis, MD, PhD |  | June 20, 2025 |
| By: | */s/ Jonathan Guarino* |  |  |
|  | Jonathan Guarino | Senior Vice President and Chief Financial Officer (Principal Financial and Accounting Officer) | June 20, 2025 |

---

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## Exhibit 5.1

**EXHIBIT 5.1**

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| | | |
|:---|:---|:---|
| NEW YORK | ![Graphic](sngx-20250620xex5d1001.jpg) | HANOI |
| LONDON | ![Graphic](sngx-20250620xex5d1001.jpg) | HO CHI MINH CITY |
| SINGAPORE | ![Graphic](sngx-20250620xex5d1001.jpg) | SHANGHAI |
| PHILADELPHIA |  | ATLANTA |
| CHICAGO |  | BALTIMORE |
| WASHINGTON, DC | *FIRM and AFFILIATE OFFICES* | WILMINGTON |
| SAN FRANCISCO |  | MIAMI |
| SILICON VALLEY |  | BOCA RATON |
| SAN DIEGO | www.duanemorris.com | PITTSBURGH |
| LOS ANGELES |  | NORTH JERSEY |
| BOSTON |  | LAS VEGAS |
| HOUSTON |  | SOUTH JERSEY |
| DALLAS |  | SYDNEY |
| FORT WORTH |  | MYANMAR |
| AUSTIN |  | ALLIANCES IN MEXICO |

---

June 20, 2025

Soligenix, Inc.

29 Emmons Drive, Suite B-10

Princeton, New Jersey 08540

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| | |
|:---|:---|
| **Re:** | **Registration Statement on Form S-8 Relating to the Soligenix, Inc. 2025 Equity Incentive Plan** |

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Ladies and Gentlemen:

We have acted as counsel to Soligenix, Inc., a Delaware corporation (the "Company"), in connection with the preparation of a registration statement on Form S-8 (the "Registration Statement") for filing with the U.S. Securities and Exchange Commission pursuant to the Securities Act of 1933, as amended (the "Act"), for the registration by the Company of 6,000,000 shares (the "Shares") of the Company's common stock, par value $0.001 per share, which Shares may be issued under the Soligenix, Inc. 2025 Equity Incentive Plan, as amended (the "Plan"). This opinion is being furnished in connection with the requirements of Item 601(b)(5) of Regulation S-K promulgated under the Act, and no opinion is expressed herein as to any matter pertaining to the contents of the Registration Statement, other than as expressly stated herein with respect to the issuance of the Shares.

In connection with the opinions set forth in this letter, we have examined the Registration Statement, originals, or copies certified or otherwise identified to our satisfaction, of the Plan, the Second Amended and Restated Certificate of Incorporation of the Company, as amended, the Amended and Restated Bylaws of the Company, as amended, and such other documents, records and other instruments as we have deemed appropriate for purposes of the opinion set forth herein. With your consent, we have relied upon certificates and other assurances of officers of the

<u>DUANE MORRIS LLP</u> <br> BOCA CENTER TOWER II5100 TOWN CENTER CIRCLE, SUITE 400BOCA RATON, FL 33486-1008 PHONE: +1 561 962 2100 FAX: +1 561 962 2101

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![Graphic](sngx-20250620xex5d1002.jpg)

Soligenix, Inc.

June 20, 2025

Company and others as to factual matters without having independently verified such factual matters.

We have assumed the genuineness of all signatures, the legal capacity of all natural persons, the authenticity of the documents submitted to us as originals, the conformity with the originals of all documents submitted to us as certified, facsimile, photostatic or other copies and the authenticity of the originals of all documents submitted to us as copies.

Subject to the limitations set forth below, we have made such examination of law as we have deemed necessary for the purpose of this opinion. This opinion is limited solely to the federal laws of the United States and the Delaware General Corporation Law as in effect on the date hereof, and no opinion is expressed with respect to such laws as subsequently amended, or any other laws, or any effect that such amended or other laws may have on the opinions expressed herein.

Based upon the foregoing, we are of the opinion that the Shares, when issued and sold in accordance with the provisions of the Plan and relevant agreements duly authorized by and in accordance with the terms of the Plan, and the Registration Statement and the related prospectus, will be legally issued, fully paid and non-assessable.

The opinions set forth above are limited to the laws of the State of Delaware as currently in effect, and no opinion is expressed with respect to such laws as subsequently amended, or any other laws, or any effect that such amended or other laws may have on the opinions expressed herein. The opinions expressed herein are limited to the matters stated herein and no opinion is implied or may be inferred beyond the matters expressly stated herein. The opinions expressed herein are given as of the date hereof, and we undertake no obligation to advise you of any changes in applicable laws after the date hereof or of any facts that might change the opinions expressed herein that we may become aware of after the date hereof.

We hereby consent to the use of this opinion as Exhibit 5.1 to the Registration Statement to be filed by the Company on or about the date hereof. In giving such opinion, we do not hereby admit that we are acting within the category of persons whose consent is required under Section 7 of the Act or the rules or regulations of the U.S. Securities and Exchange Commission thereunder.

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| |
|:---|
| Very truly yours, |
| /s/ Duane Morris LLP |

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## Exhibit 23.1

**EXHIBIT 23.1**

**CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM**

We consent to the incorporation by reference in this Registration Statement of Soligenix, Inc. on Form S-8 to be filed on or about June 20, 2025 of our report dated March 21, 2025, on our audits of the financial statements as of December 31, 2024 and 2023 and for each of the years then ended, which report was included in the Annual Report on Form 10-K filed March 21, 2025.

/s/ Cherry Bekaert LLP

CHERRY BEKAERT LLP

Tampa, Florida

June 20, 2025

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## Ex-Filing

**EXHIBIT 107**

**Calculation of Filing Fee Tables**

**Form S-8**

(Form Type)

**Soligenix, Inc.**

(Exact Name of Registrant as Specified in its Charter)

**Table 1 – Newly Registered Securities**

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| | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | |  | |  | |  | | | |
| | | **Fee** | |  | |  | | | |
| <br>**Security**<br>**Type** | <br>**Security Class**<br>**Title** |  | <br>**Amount**<br>**Registered**<sup>(1)(2)</sup> |  | **Proposed**<br>**Maximum**<br>**Offering Price**<br>**per Unit** |  | <br>**Maximum**<br>**Aggregate**<br>**Offering Price** | <br><br>**Fee Rate** | <br>**Amount of**<br>**Registration**<br>**Fee** |
| **Equity** | Common stock, par value $0.001 per share | Rule 457(c) and Rule 457(h)<sup>(3)</sup> | 6000000 | (4) | $1.79 | (3) | $10740000 | $153.10 per $1,000,000 | $1645 |
| **Total Offering Amounts** |  |  | 6000000 |  |  |  | $10740000 | $153.10 per $1,000,000 | $1645 |
| **Total Fee Offsets**<sup>(5)</sup> |  |  |  |  |  |  |  |  |  |
| **Net Fee Due** |  |  |  |  |  |  |  |  | $1645 |

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&nbsp;&nbsp;&nbsp;&nbsp;(1) The securities to be registered include options and other rights to acquire the common stock of Soligenix, Inc. (the "Registrant") issuable pursuant to the Registrant's 2025 Equity Incentive Plan (the "Plan").

&nbsp;&nbsp;&nbsp;&nbsp;(2) Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "Securities Act"), this registration statement also covers any additional securities that may be offered or issued in connection with any stock split, stock dividend or similar transaction.

&nbsp;&nbsp;&nbsp;&nbsp;(3) Calculated pursuant to Rule 457(c) and 457(h) of the Securities Act solely for purposes of calculating the registration fee. The price for these shares is based upon the average of the high and low sale prices of the Registrant's common stock reported on the Nasdaq Capital Market on June 18, 2025.

&nbsp;&nbsp;&nbsp;&nbsp;(4) Represents 6,000,000 shares of common stock available for future grants under the Plan.

&nbsp;&nbsp;&nbsp;&nbsp;(5) The Registrant does not have any fee offsets to claim.

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