# EDGAR Filing Document

**Accession Number:** 0000899148
**File Stem:** 0000913181-25-000326
**Filing Date:** 2025-12
**Character Count:** 27828
**Document Hash:** 094ed50d5598cb5c478307157d9b3322
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000913181-25-000326.hdr.sgml**: 20251201

**ACCESSION NUMBER**: 0000913181-25-000326

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20250930

**FILED AS OF DATE**: 20251201

**DATE AS OF CHANGE**: 20251201

**PERIOD START**: 20260331

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** RYDEX SERIES FUNDS
- **CENTRAL INDEX KEY:** 0000899148

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **FISCAL YEAR END:** 0331

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-07584
- **FILM NUMBER:** 251538193

**BUSINESS ADDRESS:**
- **STREET 1:** 702 KING FARM BOULEVARD
- **STREET 2:** SUITE 200
- **CITY:** ROCKVILLE
- **STATE:** MD
- **ZIP:** 20850
- **BUSINESS PHONE:** 301-296-5100

**MAIL ADDRESS:**
- **STREET 1:** 702 KING FARM BOULEVARD
- **STREET 2:** SUITE 200
- **CITY:** ROCKVILLE
- **STATE:** MD
- **ZIP:** 20850

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** RYDEX DYNAMIC FUNDS
- **DATE OF NAME CHANGE:** 20170712

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** RYDEX SERIES FUNDS
- **DATE OF NAME CHANGE:** 20000229

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** RYDEX SERIES TRUST
- **DATE OF NAME CHANGE:** 19930714

## Series and Classes Contracts Data

### Biotechnology Fund (Series ID: S000003802)

| Class ID   | Class Name     | Ticker Symbol   |
|:---|:---|:---|
| C000010594 | Investor Class | RYOIX           |
| C000010595 | Class H        | RYOAX           |
| C000010596 | Class A        | RYBOX           |
| C000010597 | Class C        | RYCFX           |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** Rydex Series Funds

- **b. Investment Company Act file number:** 811-07584

- **c. CIK number of Registrant:** 0000899148

- **d. LEI of Registrant:** 5493004D62WV1EDNTU07

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 702 King Farm Blvd., Suite 200

  - **City:** Rockville

  - **State:** MD

  - **Foreign country:** US

  - **Zip / Postal Code:** 20850

  - **Telephone number:** 301-296-5100

**Item A.2. Information about the Series.**

- **a. Name of Series:** Biotechnology Fund

- **b. EDGAR series identifier (if any):** S000003802

- **c. LEI of Series:** 549300YENG103R306541

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2026-03-31

- **b. Date as of which information is reported:** 2025-09-30

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $90172330.68

**Total Liabilities:** $163806.38

**Net Assets:** $90008524.30

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000010594 | 4.09%                | 4.90%                | 5.45%                |
| Class ID C000010597 | 4.02%                | 4.81%                | 5.37%                |
| Class ID C000010596 | 4.08%                | 4.87%                | 5.44%                |
| Class ID C000010595 | 4.07%                | 4.86%                | 5.44%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $550146.27               | $2886035.38                                |
| Month 2  | $-41726.37               | $4208081.63                                |
| Month 3  | $2925505.42              | $1842971.96                                |

### Schedule of Portfolio Investments

| Name                          | Title                           | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Vaxcyte Inc                   | Vaxcyte, Inc.                   | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |     24002 | NS      | $864552.04    | 0.96%             |  |  |  | No            |                  1 | On Loan: No      |
| Krystal Biotech Inc           | Krystal Biotech, Inc.           | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |      2302 | NS      | $406372.06    | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Akero Therapeutics Inc        | Akero Therapeutics, Inc.        | CUSIP: 00973Y108<br>LEI: 549300SI3KG74LBE2955 | Long             | EC               | CORP              | US        |     15936 | NS      | $756641.28    | 0.84%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen Inc                    | Biogen, Inc.                    | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |     12010 | NS      | $1682360.80   | 1.87%             |  |  |  | No            |                  1 | On Loan: No      |
| Sanofi SA                     | Sanofi SA                       | CUSIP: N/A<br>LEI: N/A                        | Long             |  | CORP              | FR        |      8866 | NS      | $0.01         | 0.00%             |  |  |  | No            |                  2 | On Loan: No      |
| Veracyte Inc                  | Veracyte, Inc.                  | CUSIP: 92337F107<br>LEI: 529900ESWZRHXOW27Z37 | Long             | EC               | CORP              | US        |     19032 | NS      | $653368.56    | 0.73%             |  |  |  | No            |                  1 | On Loan: No      |
| Celldex Therapeutics Inc      | Celldex Therapeutics, Inc.      | CUSIP: 15117B202<br>LEI: 529900F018DMYWH38923 | Long             | EC               | CORP              | US        |     19960 | NS      | $516365.20    | 0.57%             |  |  |  | No            |                  1 | On Loan: No      |
| Dyne Therapeutics Inc         | Dyne Therapeutics, Inc.         | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     38536 | NS      | $487480.40    | 0.54%             |  |  |  | No            |                  1 | On Loan: No      |
| Ionis Pharmaceuticals Inc     | Ionis Pharmaceuticals, Inc.     | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |     19219 | NS      | $1257306.98   | 1.40%             |  |  |  | No            |                  1 | On Loan: No      |
| Argenx SE                     | Argenx SE                       | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |      1606 | NS      | $1184521.36   | 1.32%             |  |  |  | No            |                  1 | On Loan: No      |
| Summit Therapeutics Inc       | Summit Therapeutics, Inc.       | CUSIP: 86627T108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     30185 | NS      | $623622.10    | 0.69%             |  |  |  | No            |                  1 | On Loan: No      |
| J.P. MORGAN SECURITIES LLC    | J.P. Morgan Securities LLC      | CUSIP: N/A<br>LEI: ZBUT11V806EZRVTWT807       | Long             | RA               | CORP              | US        |    109318 | PA      | $109317.72    | 0.12%             |  |  |  | No            |                  2 | On Loan: No      |
| TG Therapeutics Inc           | TG Therapeutics, Inc.           | CUSIP: 88322Q108<br>LEI: 529900X21UKABN9NJ529 | Long             | EC               | CORP              | US        |     25822 | NS      | $932819.75    | 1.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcellx Inc                   | Arcellx, Inc.                   | CUSIP: 03940C100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7093 | NS      | $582335.30    | 0.65%             |  |  |  | No            |                  1 | On Loan: No      |
| Twist Bioscience Corp         | Twist Bioscience Corp.          | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |     18229 | NS      | $512964.06    | 0.57%             |  |  |  | No            |                  1 | On Loan: No      |
| Sarepta Therapeutics Inc      | Sarepta Therapeutics, Inc.      | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |     27633 | NS      | $532487.91    | 0.59%             |  |  |  | No            |                  1 | On Loan: No      |
| AstraZeneca PLC               | AstraZeneca plc                 | CUSIP: 046353108<br>LEI: PY6ZZQWO2IZFZC3IOL08 | Long             | EC               | CORP              | GB        |     23877 | NS      | $1831843.44   | 2.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Gilead Sciences Inc           | Gilead Sciences, Inc.           | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |     39678 | NS      | $4404258.00   | 4.89%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences Inc    | Neurocrine Biosciences, Inc.    | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |     10154 | NS      | $1425418.52   | 1.58%             |  |  |  | No            |                  1 | On Loan: No      |
| Illumina Inc                  | Illumina, Inc.                  | CUSIP: 452327109<br>LEI: SQ95QG8SR5Q56LSNF682 | Long             | EC               | CORP              | US        |     14883 | NS      | $1413438.51   | 1.57%             |  |  |  | No            |                  1 | On Loan: No      |
| Viatris Inc                   | Viatris, Inc.                   | CUSIP: 92556V106<br>LEI: 254900ZZTSW7NL773X71 | Long             | EC               | CORP              | US        |    132990 | NS      | $1316601.00   | 1.46%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals Inc    | Vertex Pharmaceuticals, Inc.    | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |      9824 | NS      | $3847471.36   | 4.27%             |  |  |  | No            |                  1 | On Loan: No      |
| Revolution Medicines Inc      | Revolution Medicines, Inc.      | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |     22369 | NS      | $1044632.30   | 1.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Protagonist Therapeutics Inc  | Protagonist Therapeutics, Inc.  | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     12349 | NS      | $820344.07    | 0.91%             |  |  |  | No            |                  1 | On Loan: No      |
| BOFA SECURITIES, INC.         | BofA Securities, Inc.           | CUSIP: N/A<br>LEI: 549300HN4UKV1E2R3U73       | Long             | RA               | CORP              | US        |     78661 | PA      | $78661.25     | 0.09%             |  |  |  | No            |                  2 | On Loan: No      |
| Medpace Holdings Inc          | Medpace Holdings, Inc.          | CUSIP: 58506Q109<br>LEI: 549300H8TYEUVTW14A54 | Long             | EC               | CORP              | US        |      1338 | NS      | $687946.08    | 0.76%             |  |  |  | No            |                  1 | On Loan: No      |
| Regeneron Pharmaceuticals Inc | Regeneron Pharmaceuticals, Inc. | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |      5220 | NS      | $2935049.40   | 3.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Apellis Pharmaceuticals Inc   | Apellis Pharmaceuticals, Inc.   | CUSIP: 03753U106<br>LEI: 254900HS0ZFRXXSB9D42 | Long             | EC               | CORP              | US        |     25973 | NS      | $587768.99    | 0.65%             |  |  |  | No            |                  1 | On Loan: No      |
| Beam Therapeutics Inc         | Beam Therapeutics, Inc.         | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     24367 | NS      | $591387.09    | 0.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Recursion Pharmaceuticals Inc | Recursion Pharmaceuticals, Inc. | CUSIP: 75629V104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    109524 | NS      | $534477.12    | 0.59%             |  |  |  | No            |                  1 | On Loan: No      |
| Ascendis Pharma A/S           | Ascendis Pharma A/S             | CUSIP: 04351P101<br>LEI: 549300B66JN3W3J8GH73 | Long             | EC               | CORP              | DK        |      2436 | NS      | $484301.16    | 0.54%             |  |  |  | No            |                  1 | On Loan: No      |
| Legend Biotech Corp           | Legend Biotech Corp.            | CUSIP: 52490G102<br>LEI: 254900EIUFZTW136H859 | Long             | EC               | CORP              | KY        |     28641 | NS      | $933983.01    | 1.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Alkermes PLC                  | Alkermes plc                    | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |     36181 | NS      | $1085430.00   | 1.21%             |  |  |  | No            |                  1 | On Loan: No      |
| ADMA Biologics Inc            | ADMA Biologics, Inc.            | CUSIP: 000899104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     46352 | NS      | $679520.32    | 0.75%             |  |  |  | No            |                  1 | On Loan: No      |
| Ultragenyx Pharmaceutical Inc | Ultragenyx Pharmaceutical, Inc. | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |     21146 | NS      | $636071.68    | 0.71%             |  |  |  | No            |                  1 | On Loan: No      |
| BioNTech SE                   | BioNTech SE                     | CUSIP: 09075V102<br>LEI: 894500UZJ5LG1F8J1U58 | Long             | EC               | CORP              | DE        |      9770 | NS      | $963517.40    | 1.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Royalty Pharma PLC            | Royalty Pharma plc              | CUSIP: N/A<br>LEI: 549300FGFN7VOK8BZR03       | Long             | EC               | CORP              | US        |     45201 | NS      | $1594691.28   | 1.77%             |  |  |  | No            |                  1 | On Loan: No      |
| Amgen Inc                     | Amgen, Inc.                     | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |     16944 | NS      | $4781596.80   | 5.31%             |  |  |  | No            |                  1 | On Loan: No      |
| Amicus Therapeutics Inc       | Amicus Therapeutics, Inc.       | CUSIP: 03152W109<br>LEI: 549300MRD1SMUTNBPQ53 | Long             | EC               | CORP              | US        |     75850 | NS      | $597698.00    | 0.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytokinetics Inc              | Cytokinetics, Inc.              | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |     18238 | NS      | $1002360.48   | 1.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Insmed Inc                    | Insmed, Inc.                    | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |     14856 | NS      | $2139412.56   | 2.38%             |  |  |  | No            |                  1 | On Loan: No      |
| BeOne Medicines Ltd           | BeOne Medicines Ltd.            | CUSIP: 07725L102<br>LEI: 549300JFUK6FRD5MH739 | Long             | EC               | CORP              | CH        |      5380 | NS      | $1832966.00   | 2.04%             |  |  |  | No            |                  1 | On Loan: No      |
| ACADIA Pharmaceuticals Inc    | ACADIA Pharmaceuticals, Inc.    | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |     27963 | NS      | $596730.42    | 0.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Moderna Inc                   | Moderna, Inc.                   | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |     44782 | NS      | $1156719.06   | 1.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Halozyme Therapeutics Inc     | Halozyme Therapeutics, Inc.     | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |     14945 | NS      | $1096066.30   | 1.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Ideaya Biosciences Inc        | Ideaya Biosciences, Inc.        | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |     22690 | NS      | $617394.90    | 0.69%             |  |  |  | No            |                  1 | On Loan: No      |
| Madrigal Pharmaceuticals Inc  | Madrigal Pharmaceuticals, Inc.  | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |      1142 | NS      | $523789.72    | 0.58%             |  |  |  | No            |                  1 | On Loan: No      |
| Exact Sciences Corp           | Exact Sciences Corp.            | CUSIP: 30063P105<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |     22262 | NS      | $1217954.02   | 1.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Dynavax Technologies Corp     | Dynavax Technologies Corp.      | CUSIP: 268158201<br>LEI: 549300T5URIXWDILX594 | Long             | EC               | CORP              | US        |     42694 | NS      | $423951.42    | 0.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Immunovant Inc                | Immunovant, Inc.                | CUSIP: 45258J102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     25277 | NS      | $407465.24    | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| BioMarin Pharmaceutical Inc   | BioMarin Pharmaceutical, Inc.   | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |     22529 | NS      | $1220170.64   | 1.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Bridgebio Pharma Inc          | Bridgebio Pharma, Inc.          | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |     22288 | NS      | $1157638.72   | 1.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Intellia Therapeutics Inc     | Intellia Therapeutics, Inc.     | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |     37341 | NS      | $644879.07    | 0.72%             |  |  |  | No            |                  1 | On Loan: No      |
| Viking Therapeutics Inc       | Viking Therapeutics, Inc.       | CUSIP: 92686J106<br>LEI: 529900IVC72YPFA25M37 | Long             | EC               | CORP              | US        |     25572 | NS      | $672032.16    | 0.75%             |  |  |  | No            |                  1 | On Loan: No      |
| Avidity Biosciences Inc       | Avidity Biosciences, Inc.       | CUSIP: 05370A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     22699 | NS      | $988995.43    | 1.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Roivant Sciences Ltd.         | Roivant Sciences Ltd.           | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |     65652 | NS      | $993314.76    | 1.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Arrowhead Pharmaceuticals Inc | Arrowhead Pharmaceuticals, Inc. | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |     25732 | NS      | $887496.68    | 0.99%             |  |  |  | No            |                  1 | On Loan: No      |
| AbbVie Inc                    | AbbVie, Inc.                    | CUSIP: 00287Y109<br>LEI: FR5LCKFTG8054YNNRU85 | Long             | EC               | CORP              | US        |     34334 | NS      | $7949694.36   | 8.83%             |  |  |  | No            |                  1 | On Loan: No      |
| Exelixis Inc                  | Exelixis, Inc.                  | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |     31282 | NS      | $1291946.60   | 1.44%             |  |  |  | No            |                  1 | On Loan: No      |
| Agios Pharmaceuticals Inc     | Agios Pharmaceuticals, Inc.     | CUSIP: 00847X104<br>LEI: 529900ONJHY8EOGYT555 | Long             | EC               | CORP              | US        |     13883 | NS      | $557263.62    | 0.62%             |  |  |  | No            |                  1 | On Loan: No      |
| Iovance Biotherapeutics Inc   | Iovance Biotherapeutics, Inc.   | CUSIP: 462260100<br>LEI: 2549002L8WT2ACU5Q878 | Long             | EC               | CORP              | US        |     84719 | NS      | $183840.23    | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Crinetics Pharmaceuticals Inc | Crinetics Pharmaceuticals, Inc. | CUSIP: 22663K107<br>LEI: 549300Q1CNFXK5P31D28 | Long             | EC               | CORP              | US        |     20861 | NS      | $868860.65    | 0.97%             |  |  |  | No            |                  1 | On Loan: No      |
| Natera Inc                    | Natera, Inc.                    | CUSIP: 632307104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     10600 | NS      | $1706282.00   | 1.90%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC Therapeutics Inc          | PTC Therapeutics, Inc.          | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |     13705 | NS      | $841075.85    | 0.93%             |  |  |  | No            |                  1 | On Loan: No      |
| Guardant Health Inc           | Guardant Health, Inc.           | CUSIP: 40131M109<br>LEI: 254900M8C3E5VC8BR186 | Long             | EC               | CORP              | US        |     17952 | NS      | $1121640.96   | 1.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Incyte Corp                   | Incyte Corp.                    | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |     16980 | NS      | $1440073.80   | 1.60%             |  |  |  | No            |                  1 | On Loan: No      |
| Corteva Inc                   | Corteva, Inc.                   | CUSIP: 22052L104<br>LEI: 549300WZN9I2QKLS0O94 | Long             | EC               | CORP              | US        |     37439 | NS      | $2531999.57   | 2.81%             |  |  |  | No            |                  1 | On Loan: No      |
| Denali Therapeutics Inc       | Denali Therapeutics, Inc.       | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |     34334 | NS      | $498529.68    | 0.55%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals Inc   | Alnylam Pharmaceuticals, Inc.   | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |      6549 | NS      | $2986344.00   | 3.32%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvalent Inc                  | Nuvalent, Inc.                  | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      9101 | NS      | $787054.48    | 0.87%             |  |  |  | No            |                  1 | On Loan: No      |
| United Therapeutics Corp      | United Therapeutics Corp.       | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |      2944 | NS      | $1234154.24   | 1.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Axsome Therapeutics Inc       | Axsome Therapeutics, Inc.       | CUSIP: 05464T104<br>LEI: 549300EXGR0XLRJEIB95 | Long             | EC               | CORP              | US        |      7076 | NS      | $859380.20    | 0.95%             |  |  |  | No            |                  1 | On Loan: No      |
| Novavax Inc                   | Novavax, Inc.                   | CUSIP: 670002401<br>LEI: 529900J4GJHPEPQ23205 | Long             | EC               | CORP              | US        |     52500 | NS      | $455175.00    | 0.51%             |  |  |  | No            |                  1 | On Loan: No      |
| CRISPR Therapeutics AG        | CRISPR Therapeutics AG          | CUSIP: N/A<br>LEI: 506700O6IRRIQLT3W370       | Long             | EC               | CORP              | US        |     17765 | NS      | $1151349.65   | 1.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Jazz Pharmaceuticals PLC      | Jazz Pharmaceuticals plc        | CUSIP: N/A<br>LEI: 635400GAUMJCLEZRRV50       | Long             | EC               | CORP              | US        |      9538 | NS      | $1257108.40   | 1.40%             |  |  |  | No            |                  1 | On Loan: No      |
| Soleno Therapeutics Inc       | Soleno Therapeutics, Inc.       | CUSIP: 834203309<br>LEI: 5493003LCY77N7FXK844 | Long             | EC               | CORP              | US        |      7138 | NS      | $482528.80    | 0.54%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2025-10-30

**Name of Applicant:** Rydex Series Funds

**Signature:** James Howley

**Name of Signer:** James Howley

**Title:** CFO