# EDGAR Filing Document

**Accession Number:** 0002018299
**File Stem:** 0001213900-26-057335
**Filing Date:** 2026-5
**Character Count:** 9319
**Document Hash:** 6ecd8ef3763ab3413b5c43b83f02e528
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001213900-26-057335.hdr.sgml**: 20260515

**ACCESSION NUMBER**: 0001213900-26-057335

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20260331

**FILED AS OF DATE**: 20260515

**DATE AS OF CHANGE**: 20260515

**EFFECTIVENESS DATE**: 20260515

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Boxer Capital Management, LLC
- **CENTRAL INDEX KEY:** 0002018299

**ORGANIZATION NAME:**
- **EIN:** 990921494
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-25329
- **FILM NUMBER:** 26984153

**BUSINESS ADDRESS:**
- **STREET 1:** 12860 EL CAMINO REAL
- **STREET 2:** SUITE 300
- **CITY:** SAN DIEGO
- **STATE:** CA
- **ZIP:** 92130
- **BUSINESS PHONE:** 8584003115

**MAIL ADDRESS:**
- **STREET 1:** 12860 EL CAMINO REAL
- **STREET 2:** SUITE 300
- **CITY:** SAN DIEGO
- **STATE:** CA
- **ZIP:** 92130

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 03-31-2026

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** Boxer Capital Management LLC<br>**Address:** 12860 El Camino Real<br>Suite 300<br>San Diego, CA 92130

**Form 13F File Number:** 028-25329

**CRD Number (if applicable):** 000330106

**SEC File Number (if applicable):** 801-130351

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Tiffany Ayres<br>**Title:** Chief Compliance Officer<br>**Phone:** 858-400-3139

**Signature, Place, and Date of Signing:**

Tiffany Ayres  San Diego, CA  05-15-2026<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 54

**Form 13F Information Table Value Total:** $761653648

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| ABIVAX SA | SPONSORED ADS | 00370M103 |  | 22270000 | 200000 | SH |  | SOLE |  | 200000 | 0 | 0 |
| ALLOGENE THERAPEUTICS INC | COM | 019770106 |  | 6649000 | 2725000 | SH |  | SOLE |  | 2725000 | 0 | 0 |
| AMYLYX PHARMACEUTICALS INC | COM | 03237H101 |  | 11120000 | 800000 | SH |  | SOLE |  | 800000 | 0 | 0 |
| AN2 THERAPEUTICS INC | COM | 037326105 |  | 2561700 | 749035 | SH |  | SOLE |  | 749035 | 0 | 0 |
| APOGEE THERAPEUTICS INC | COM | 03770N101 |  | 5891900 | 70000 | SH |  | SOLE |  | 70000 | 0 | 0 |
| AVALO THERAPEUTICS INC | COM NEW | 05338F306 |  | 4479000 | 300000 | SH |  | SOLE |  | 300000 | 0 | 0 |
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 |  | 17936000 | 590000 | SH |  | SOLE |  | 590000 | 0 | 0 |
| CELCUITY INC | COM | 15102K100 |  | 25681500 | 225000 | SH |  | SOLE |  | 225000 | 0 | 0 |
| CLENE INC | COM NEW | 185634201 |  | 2354149 | 477515 | SH |  | SOLE |  | 477515 | 0 | 0 |
| COGENT BIOSCIENCES INC | COM | 19240Q201 |  | 8660250 | 225000 | SH |  | SOLE |  | 225000 | 0 | 0 |
| CONTINEUM THERAPEUTICS INC | CL A | 21217B100 |  | 6451640 | 494000 | SH |  | SOLE |  | 494000 | 0 | 0 |
| CORCEPT THERAPEUTICS INC | COM | 218352102 |  | 10077500 | 250000 | SH |  | SOLE |  | 250000 | 0 | 0 |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 |  | 16093000 | 1100000 | SH |  | SOLE |  | 1100000 | 0 | 0 |
| CRESCENT BIOPHARMA INC. | COM | 38000Q201 |  | 8334212 | 453686 | SH |  | SOLE |  | 453686 | 0 | 0 |
| CYBIN INC | COM NEW | 23256X407 |  | 3072000 | 640000 | SH |  | SOLE |  | 640000 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 6591000 | 100000 | SH |  | SOLE |  | 100000 | 0 | 0 |
| DEFINIUM THERAPEUTICS INC | COM SHS | 24477V105 |  | 11311650 | 598500 | SH |  | SOLE |  | 598500 | 0 | 0 |
| INOVIO PHARMACEUTICALS INC | COM SHS | 45773H409 |  | 4124012 | 2370122 | SH |  | SOLE |  | 2370122 | 0 | 0 |
| INVIVYD INC | COM | 00534A102 |  | 1950000 | 1500000 | SH |  | SOLE |  | 1500000 | 0 | 0 |
| KALVISTA PHARMACEUTICALS INC | COM | 483497103 |  | 410652 | 20400 | SH |  | SOLE |  | 20400 | 0 | 0 |
| KARYOPHARM THERAPEUTICS INC | COM NEW | 48576U205 |  | 1685126 | 302536 | SH |  | SOLE |  | 302536 | 0 | 0 |
| KODIAK SCIENCES INC | COM | 50015M109 |  | 51881320 | 1361000 | SH |  | SOLE |  | 1361000 | 0 | 0 |
| KYMERA THERAPEUTICS INC | COM | 501575104 |  | 27410739 | 329100 | SH |  | SOLE |  | 329100 | 0 | 0 |
| LB PHARMACEUTICALS INC | COM SHS | 50180M108 |  | 1726200 | 70000 | SH |  | SOLE |  | 70000 | 0 | 0 |
| MILESTONE PHARMACEUTICALS IN | COM | 59935V107 |  | 793333 | 666666 | SH |  | SOLE |  | 666666 | 0 | 0 |
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 |  | 5126000 | 275000 | SH |  | SOLE |  | 275000 | 0 | 0 |
| NURIX THERAPEUTICS INC | COM | 67080M103 |  | 1550000 | 100000 | SH |  | SOLE |  | 100000 | 0 | 0 |
| OCULAR THERAPEUTIX INC | COM | 67576A100 |  | 2964500 | 350000 | SH |  | SOLE |  | 350000 | 0 | 0 |
| OPUS GENETICS INC | COM | 67577R102 |  | 10237500 | 2250000 | SH |  | SOLE |  | 2250000 | 0 | 0 |
| ORIC PHARMACEUTICALS INC | COM | 68622P109 |  | 2236255 | 176500 | SH |  | SOLE |  | 176500 | 0 | 0 |
| PALISADE BIO INC | COM | 696389402 |  | 8399781 | 4799875 | SH |  | SOLE |  | 4799875 | 0 | 0 |
| PEPGEN INC | COM | 713317105 |  | 483019 | 272892 | SH |  | SOLE |  | 272892 | 0 | 0 |
| PRAXIS PRECISION MEDICINES I | COM NEW | 74006W207 |  | 14967981 | 46457 | SH |  | SOLE |  | 46457 | 0 | 0 |
| PRECIGEN INC | COM | 74017N105 |  | 13545000 | 3500000 | SH |  | SOLE |  | 3500000 | 0 | 0 |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 |  | 17918000 | 170000 | SH |  | SOLE |  | 170000 | 0 | 0 |
| PTC THERAPEUTICS INC | COM | 69366J200 |  | 13626000 | 200000 | SH |  | SOLE |  | 200000 | 0 | 0 |
| REGENXBIO INC | COM | 75901B107 |  | 125700 | 15000 | SH |  | SOLE |  | 15000 | 0 | 0 |
| RELMADA THERAPEUTICS INC | COM | 75955J402 |  | 5861058 | 842106 | SH |  | SOLE |  | 842106 | 0 | 0 |
| REPLIMUNE GROUP INC | COM | 76029N106 |  | 8988750 | 1175000 | SH |  | SOLE |  | 1175000 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 48625000 | 500000 | SH |  | SOLE |  | 500000 | 0 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607100 |  | 3264000 | 150000 | SH |  | SOLE |  | 150000 | 0 | 0 |
| SOLENO THERAPEUTICS INC | COM | 834203309 |  | 6696000 | 200000 | SH |  | SOLE |  | 200000 | 0 | 0 |
| SOLID BIOSCIENCES INC | COM NEW | 83422E204 |  | 2160000 | 300000 | SH |  | SOLE |  | 300000 | 0 | 0 |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 |  | 3615000 | 75000 | SH |  | SOLE |  | 75000 | 0 | 0 |
| SURROZEN INC | COM NEW | 86889P208 |  | 22322843 | 766318 | SH |  | SOLE |  | 766318 | 0 | 0 |
| TANGO THERAPEUTICS INC | COM | 87583X109 |  | 227530501 | 10876219 | SH |  | SOLE |  | 10876219 | 0 | 0 |
| TERNS PHARMACEUTICALS INC | COM | 880881107 |  | 19770000 | 375000 | SH |  | SOLE |  | 375000 | 0 | 0 |
| UNIQURE NV | SHS | N90064101 |  | 10823700 | 662000 | SH |  | SOLE |  | 662000 | 0 | 0 |
| UPSTREAM BIO INC | COM | 91678A107 |  | 1350000 | 150000 | SH |  | SOLE |  | 150000 | 0 | 0 |
| UROGEN PHARMA LTD | COM | M96088105 |  | 8990000 | 500000 | SH |  | SOLE |  | 500000 | 0 | 0 |
| VAXCYTE INC | COM | 92243G108 |  | 18885750 | 325000 | SH |  | SOLE |  | 325000 | 0 | 0 |
| VIR BIOTECHNOLOGY INC | COM | 92764N102 |  | 16719360 | 1866000 | SH |  | SOLE |  | 1866000 | 0 | 0 |
| ZURA BIO LTD | CLASS A ORD SHS | G9TY5A101 |  | 5355000 | 900000 | SH |  | SOLE |  | 900000 | 0 | 0 |
| SURROZEN INC | *W EXP 08/01/203 | 86889P117 |  | 1067 | 66666 | SH |  | SOLE |  | 66666 | 0 | 0 |

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