# EDGAR Filing Document

**Accession Number:** 0001064642
**File Stem:** 0001752724-25-211042
**Filing Date:** 2025-8
**Character Count:** 48150
**Document Hash:** cf2662bb80b16a624a37fa14000230f0
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001752724-25-211042.hdr.sgml**: 20250828

**ACCESSION NUMBER**: 0001752724-25-211042

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20250630

**FILED AS OF DATE**: 20250828

**DATE AS OF CHANGE**: 20250828

**PERIOD START**: 20250630

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** SPDR SERIES TRUST
- **CENTRAL INDEX KEY:** 0001064642

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** MA

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-08839
- **FILM NUMBER:** 251269985

**BUSINESS ADDRESS:**
- **STREET 1:** ONE IRON STREET
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02210
- **BUSINESS PHONE:** 6176643920

**MAIL ADDRESS:**
- **STREET 1:** ONE IRON STREET
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02210

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** STREETTRACKS SERIES TRUST
- **DATE OF NAME CHANGE:** 20000925

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** INDEX EXCHANGE LISTED SECURITIES TRUST
- **DATE OF NAME CHANGE:** 19980622

## Series and Classes Contracts Data

### SPDR(R) S&P(R) Biotech ETF (Series ID: S000010018)

| Class ID   | Class Name                 | Ticker Symbol   |
|:---|:---|:---|
| C000027706 | SPDR(R) S&P(R) Biotech ETF | XBI             |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** SPDR SERIES TRUST

- **b. Investment Company Act file number:** 811-08839

- **c. CIK number of Registrant:** 0001064642

- **d. LEI of Registrant:** 5493004JVD6CQEEJSS37

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** One Iron Street

  - **City:** Boston

  - **State:** MA

  - **Foreign country:** US

  - **Zip / Postal Code:** 02210

  - **Telephone number:** 617-664-8594

**Item A.2. Information about the Series.**

- **a. Name of Series:** SPDR(R) S&P(R) Biotech ETF

- **b. EDGAR series identifier (if any):** S000010018

- **c. LEI of Series:** 549300Y3ODFMPD5XXL58

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2025-06-30

- **b. Date as of which information is reported:** 2025-06-30

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $5129914855.36

**Total Liabilities:** $299534473.12

**Net Assets:** $4830380382.24

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000027706 | 2.35%                | -4.60%               | 4.68%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $35330649.15             | $71378877.41                               |
| Month 2  | $-20882441.76            | $-215568924.17                             |
| Month 3  | $-194137981.64           | $416821998.09                              |

### Schedule of Portfolio Investments

| Name                               | Title                                                      | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Ionis Pharmaceuticals Inc          | Ionis Pharmaceuticals Inc                                  | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |   1770444 | NS      | $69950242.44  | 1.45%             |  |  |  | No            |                  1 | On Loan: —       |
| MiMedx Group Inc                   | MiMedx Group Inc                                           | CUSIP: 602496101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    770189 | NS      | $4705854.79   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Rigel Pharmaceuticals Inc          | Rigel Pharmaceuticals Inc                                  | CUSIP: 766559702<br>LEI: 529900KPTNUS5J8K9K66 | Long             | EC               | CORP              | US        |    223832 | NS      | $4192373.36   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Taysha Gene Therapies Inc          | Taysha Gene Therapies Inc                                  | CUSIP: 877619106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1451524 | NS      | $3353020.44   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Arrowhead Pharmaceuticals Inc      | Arrowhead Pharmaceuticals Inc                              | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |   1735649 | NS      | $27423254.20  | 0.57%             |  |  |  | No            |                  1 | On Loan: —       |
| KalVista Pharmaceuticals Inc       | KalVista Pharmaceuticals Inc                               | CUSIP: 483497103<br>LEI: 529900Q7IDA3WUGRZA51 | Long             | EC               | CORP              | US        |    573576 | NS      | $6484276.68   | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Protagonist Therapeutics Inc       | Protagonist Therapeutics Inc                               | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    984994 | NS      | $54440618.38  | 1.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Rhythm Pharmaceuticals Inc         | Rhythm Pharmaceuticals Inc                                 | CUSIP: 76243J105<br>LEI: 529900JPNWXQ8DPLA551 | Long             | EC               | CORP              | US        |    631155 | NS      | $39882684.45  | 0.83%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals Inc        | Alnylam Pharmaceuticals Inc                                | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |    393681 | NS      | $128375437.29 | 2.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Anavex Life Sciences Corp          | Anavex Life Sciences Corp                                  | CUSIP: 032797300<br>LEI: 549300K1I5L8COCQ8W36 | Long             | EC               | CORP              | US        |   1126867 | NS      | $10389713.74  | 0.22%             |  |  |  | No            |                  1 | On Loan: —       |
| Vera Therapeutics Inc              | Vera Therapeutics Inc                                      | CUSIP: 92337R101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    881362 | NS      | $20764888.72  | 0.43%             |  |  |  | No            |                  1 | On Loan: —       |
| Akebia Therapeutics Inc            | Akebia Therapeutics Inc                                    | CUSIP: 00972D105<br>LEI: 549300CBQEHMKEEGNX42 | Long             | EC               | CORP              | US        |   3105538 | NS      | $11304158.32  | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Relay Therapeutics Inc             | Relay Therapeutics Inc                                     | CUSIP: 75943R102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2225186 | NS      | $7699143.56   | 0.16%             |  |  |  | No            |                  1 | On Loan: —       |
| Kura Oncology Inc                  | Kura Oncology Inc                                          | CUSIP: 50127T109<br>LEI: 5493005QORQTZCZYOP39 | Long             | EC               | CORP              | US        |   1285441 | NS      | $7416994.57   | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals Inc         | Vertex Pharmaceuticals Inc                                 | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |    259826 | NS      | $115674535.20 | 2.39%             |  |  |  | No            |                  1 | On Loan: No      |
| BioCryst Pharmaceuticals Inc       | BioCryst Pharmaceuticals Inc                               | CUSIP: 09058V103<br>LEI: 549300Z0INP1Z5NP6J59 | Long             | EC               | CORP              | US        |   3680438 | NS      | $32976724.48  | 0.68%             |  |  |  | No            |                  1 | On Loan: No      |
| Exact Sciences Corp                | Exact Sciences Corp                                        | CUSIP: 30063P105<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |   2111976 | NS      | $112230404.64 | 2.32%             |  |  |  | No            |                  1 | On Loan: No      |
| Verve Therapeutics Inc             | Verve Therapeutics Inc                                     | CUSIP: 92539P101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    920015 | NS      | $10331768.45  | 0.21%             |  |  |  | No            |                  1 | On Loan: —       |
| Keros Therapeutics Inc             | Keros Therapeutics Inc                                     | CUSIP: 492327101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    663999 | NS      | $8864386.65   | 0.18%             |  |  |  | No            |                  1 | On Loan: —       |
| CONTRA MIRATI THERAPEU             | CONTRA MIRATI THERAPEU                                     | CUSIP: 604CVR027<br>LEI: 529900GYRW59IDQV6N54 | N/A              | DE               |  | US        |   1369552 | NS      | $958686.40    | 0.02%             |  |  |  | No            |                  2 | On Loan: —       |
| Catalyst Pharmaceuticals Inc       | Catalyst Pharmaceuticals Inc                               | CUSIP: 14888U101<br>LEI: 5299004O0R5XXLA5H544 | Long             | EC               | CORP              | US        |   1170518 | NS      | $25400240.60  | 0.53%             |  |  |  | No            |                  1 | On Loan: No      |
| AbbVie Inc                         | AbbVie Inc                                                 | CUSIP: 00287Y109<br>LEI: FR5LCKFTG8054YNNRU85 | Long             | EC               | CORP              | US        |    613953 | NS      | $113961955.86 | 2.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Immunome Inc                       | Immunome Inc                                               | CUSIP: 45257U108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    934328 | NS      | $8689250.40   | 0.18%             |  |  |  | No            |                  1 | On Loan: —       |
| Myriad Genetics Inc                | Myriad Genetics Inc                                        | CUSIP: 62855J104<br>LEI: 52990044IHUOUMETT163 | Long             | EC               | CORP              | US        |   1381111 | NS      | $7333699.41   | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Dyne Therapeutics Inc              | Dyne Therapeutics Inc                                      | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1348253 | NS      | $12835368.56  | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| GRAIL Inc                          | GRAIL Inc                                                  | CUSIP: 384747101<br>LEI: 2549009XSNESW3VE8024 | Long             | EC               | CORP              | US        |    501777 | NS      | $25801373.34  | 0.53%             |  |  |  | No            |                  1 | On Loan: —       |
| BioMarin Pharmaceutical Inc        | BioMarin Pharmaceutical Inc                                | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |   2056779 | NS      | $113061141.63 | 2.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Geron Corp                         | Geron Corp                                                 | CUSIP: 374163103<br>LEI: 549300T282D7Z2YESL90 | Long             | EC               | CORP              | US        |  10132123 | NS      | $14286293.43  | 0.30%             |  |  |  | No            |                  1 | On Loan: —       |
| Viridian Therapeutics Inc          | Viridian Therapeutics Inc                                  | CUSIP: 92790C104<br>LEI: 549300C775BNYF550E70 | Long             | EC               | CORP              | US        |    934375 | NS      | $13062562.50  | 0.27%             |  |  |  | No            |                  1 | On Loan: —       |
| Spyre Therapeutics Inc             | Spyre Therapeutics Inc                                     | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |    623242 | NS      | $9329932.74   | 0.19%             |  |  |  | No            |                  1 | On Loan: —       |
| OMNIAB INC                         | OMNIAB INC                                                 | CUSIP: 68218J301<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    161959 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  3 | On Loan: —       |
| Beam Therapeutics Inc              | Beam Therapeutics Inc                                      | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1502200 | NS      | $25552422.00  | 0.53%             |  |  |  | No            |                  1 | On Loan: —       |
| Mineralys Therapeutics Inc         | Mineralys Therapeutics Inc                                 | CUSIP: 603170101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    701637 | NS      | $9493148.61   | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Travere Therapeutics Inc           | Travere Therapeutics Inc                                   | CUSIP: 89422G107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1514647 | NS      | $22416775.60  | 0.46%             |  |  |  | No            |                  1 | On Loan: —       |
| AnaptysBio Inc                     | AnaptysBio Inc                                             | CUSIP: 032724106<br>LEI: 529900HH4WQT03IG1A12 | Long             | EC               | CORP              | US        |    328086 | NS      | $7283509.20   | 0.15%             |  |  |  | No            |                  1 | On Loan: —       |
| State Street Global Advisors       | State Street Institutional US Government Money Market Fund | CUSIP: 857492706<br>LEI: 549300BZ5TGIFZUZDZ37 | Long             | STIV             | RF                | US        |   5090570 | NS      | $5090570.33   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Agios Pharmaceuticals Inc          | Agios Pharmaceuticals Inc                                  | CUSIP: 00847X104<br>LEI: 529900ONJHY8EOGYT555 | Long             | EC               | CORP              | US        |    604144 | NS      | $20093829.44  | 0.42%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcturus Therapeutics Holdings Inc | Arcturus Therapeutics Holdings Inc                         | CUSIP: 03969T109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    460395 | NS      | $5989738.95   | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Intellia Therapeutics Inc          | Intellia Therapeutics Inc                                  | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |   1575098 | NS      | $14774419.24  | 0.31%             |  |  |  | No            |                  1 | On Loan: —       |
| Halozyme Therapeutics Inc          | Halozyme Therapeutics Inc                                  | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |   2183118 | NS      | $113565798.36 | 2.35%             |  |  |  | No            |                  1 | On Loan: —       |
| Apellis Pharmaceuticals Inc        | Apellis Pharmaceuticals Inc                                | CUSIP: 03753U106<br>LEI: 254900HS0ZFRXXSB9D42 | Long             | EC               | CORP              | US        |   1759267 | NS      | $30452911.77  | 0.63%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen Inc                         | Biogen Inc                                                 | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |    883549 | NS      | $110964918.91 | 2.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Madrigal Pharmaceuticals Inc       | Madrigal Pharmaceuticals Inc                               | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |    300014 | NS      | $90796236.96  | 1.88%             |  |  |  | No            |                  1 | On Loan: No      |
| Arbutus Biopharma Corp             | Arbutus Biopharma Corp                                     | CUSIP: 03879J100<br>LEI: 25490064CESONAUIAS23 | Long             | EC               | CORP              | CA        |   1081798 | NS      | $3342755.82   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| United Therapeutics Corp           | United Therapeutics Corp                                   | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |    425233 | NS      | $122190702.55 | 2.53%             |  |  |  | No            |                  1 | On Loan: No      |
| ACADIA Pharmaceuticals Inc         | ACADIA Pharmaceuticals Inc                                 | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |   1537756 | NS      | $33169396.92  | 0.69%             |  |  |  | No            |                  1 | On Loan: No      |
| Cullinan Therapeutics Inc          | Cullinan Therapeutics Inc                                  | CUSIP: 230031106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    479697 | NS      | $3612118.41   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Viking Therapeutics Inc            | Viking Therapeutics Inc                                    | CUSIP: 92686J106<br>LEI: 529900IVC72YPFA25M37 | Long             | EC               | CORP              | US        |   1925948 | NS      | $51037622.00  | 1.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Revolution Medicines Inc           | Revolution Medicines Inc                                   | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |   1870857 | NS      | $68828829.03  | 1.42%             |  |  |  | No            |                  1 | On Loan: —       |
| Moderna Inc                        | Moderna Inc                                                | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |   4236470 | NS      | $116884207.30 | 2.42%             |  |  |  | No            |                  1 | On Loan: —       |
| Biohaven Ltd                       | Biohaven Ltd                                               | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | VG        |   1482109 | NS      | $20912557.99  | 0.43%             |  |  |  | No            |                  1 | On Loan: No      |
| Iovance Biotherapeutics Inc        | Iovance Biotherapeutics Inc                                | CUSIP: 462260100<br>LEI: 2549002L8WT2ACU5Q878 | Long             | EC               | CORP              | US        |   3576368 | NS      | $6151352.96   | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| ORIC Pharmaceuticals Inc           | ORIC Pharmaceuticals Inc                                   | CUSIP: 68622P109<br>LEI: 54930033FJRNEYBW0L25 | Long             | EC               | CORP              | US        |    521504 | NS      | $5293265.60   | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| Dianthus Therapeutics Inc          | Dianthus Therapeutics Inc                                  | CUSIP: 252828108<br>LEI: 549300Z3N6ODPCOFC890 | Long             | EC               | CORP              | US        |    348806 | NS      | $6498255.78   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Recursion Pharmaceuticals Inc      | Recursion Pharmaceuticals Inc                              | CUSIP: 75629V104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   4355528 | NS      | $22038971.68  | 0.46%             |  |  |  | No            |                  1 | On Loan: —       |
| Celldex Therapeutics Inc           | Celldex Therapeutics Inc                                   | CUSIP: 15117B202<br>LEI: 529900F018DMYWH38923 | Long             | EC               | CORP              | US        |    875091 | NS      | $17808101.85  | 0.37%             |  |  |  | No            |                  1 | On Loan: —       |
| Twist Bioscience Corp              | Twist Bioscience Corp                                      | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |    925097 | NS      | $34034318.63  | 0.70%             |  |  |  | No            |                  1 | On Loan: —       |
| CRISPR Therapeutics AG             | CRISPR Therapeutics AG                                     | CUSIP: 000000000<br>LEI: 506700O6IRRIQLT3W370 | Long             | EC               | CORP              | CH        |   1398409 | NS      | $68018613.76  | 1.41%             |  |  |  | No            |                  1 | On Loan: —       |
| Disc Medicine Inc                  | Disc Medicine Inc                                          | CUSIP: 254604101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    385042 | NS      | $20391824.32  | 0.42%             |  |  |  | No            |                  1 | On Loan: —       |
| Denali Therapeutics Inc            | Denali Therapeutics Inc                                    | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |   1495177 | NS      | $20917526.23  | 0.43%             |  |  |  | No            |                  1 | On Loan: —       |
| Akero Therapeutics Inc             | Akero Therapeutics Inc                                     | CUSIP: 00973Y108<br>LEI: 549300SI3KG74LBE2955 | Long             | EC               | CORP              | US        |   1138863 | NS      | $60769729.68  | 1.26%             |  |  |  | No            |                  1 | On Loan: —       |
| ImmunityBio Inc                    | ImmunityBio Inc                                            | CUSIP: 45256X103<br>LEI: 529900J9XLBR4HFL4B83 | Long             | EC               | CORP              | US        |   3087394 | NS      | $8150720.16   | 0.17%             |  |  |  | No            |                  1 | On Loan: —       |
| Incyte Corp                        | Incyte Corp                                                | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |   1707564 | NS      | $116285108.40 | 2.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Krystal Biotech Inc                | Krystal Biotech Inc                                        | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |    423891 | NS      | $58268056.86  | 1.21%             |  |  |  | No            |                  1 | On Loan: —       |
| CONTRA INHIBRX INC                 | CONTRA INHIBRX INC                                         | CUSIP: 457CVR017<br>LEI: 549300VBKG2LTV1TLY22 | N/A              | DE               |  | US        |   1645973 | NS      | $1069882.45   | 0.02%             |  |  |  | No            |                  2 | On Loan: —       |
| ADMA Biologics Inc                 | ADMA Biologics Inc                                         | CUSIP: 000899104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   3252138 | NS      | $59221432.98  | 1.23%             |  |  |  | No            |                  1 | On Loan: —       |
| State Street Global Advisors       | State Street Navigator Securities Lending Portfolio II     | CUSIP: 857492706<br>LEI: 5493008BJIBKQ5KTIF74 | Long             | STIV             | RF                | US        | 298148176 | NS      | $298148176.25 | 6.17%             |  |  |  | No            |                  1 | On Loan: No      |
| ArriVent Biopharma Inc             | ArriVent Biopharma Inc                                     | CUSIP: 04272N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    192612 | NS      | $4193163.24   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Amgen Inc                          | Amgen Inc                                                  | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |    402868 | NS      | $112484774.28 | 2.33%             |  |  |  | No            |                  1 | On Loan: No      |
| Ideaya Biosciences Inc             | Ideaya Biosciences Inc                                     | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |   1342897 | NS      | $28227694.94  | 0.58%             |  |  |  | No            |                  1 | On Loan: —       |
| Avidity Biosciences Inc            | Avidity Biosciences Inc                                    | CUSIP: 05370A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1551722 | NS      | $44068904.80  | 0.91%             |  |  |  | No            |                  1 | On Loan: —       |
| Replimune Group Inc                | Replimune Group Inc                                        | CUSIP: 76029N106<br>LEI: 549300AY704NEIRC4K64 | Long             | EC               | CORP              | US        |    972669 | NS      | $9036095.01   | 0.19%             |  |  |  | No            |                  1 | On Loan: —       |
| Veracyte Inc                       | Veracyte Inc                                               | CUSIP: 92337F107<br>LEI: 529900ESWZRHXOW27Z37 | Long             | EC               | CORP              | US        |   1330783 | NS      | $35971064.49  | 0.74%             |  |  |  | No            |                  1 | On Loan: —       |
| Vaxcyte Inc                        | Vaxcyte Inc                                                | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |   2015646 | NS      | $65528651.46  | 1.36%             |  |  |  | No            |                  1 | On Loan: —       |
| Humacyte Inc                       | Humacyte Inc                                               | CUSIP: 44486Q103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2265482 | NS      | $4734857.38   | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| Blueprint Medicines Corp           | Blueprint Medicines Corp                                   | CUSIP: 09627Y109<br>LEI: 5299004CC60O9T5HVM83 | Long             | EC               | CORP              | US        |    740718 | NS      | $94945233.24  | 1.97%             |  |  |  | No            |                  1 | On Loan: No      |
| CareDx Inc                         | CareDx Inc                                                 | CUSIP: 14167L103<br>LEI: 549300NQOFKL9NON0U06 | Long             | EC               | CORP              | US        |    872781 | NS      | $17054140.74  | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Bridgebio Pharma Inc               | Bridgebio Pharma Inc                                       | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |   2406549 | NS      | $103914785.82 | 2.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvalent Inc                       | Nuvalent Inc                                               | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    591735 | NS      | $45149380.50  | 0.93%             |  |  |  | No            |                  1 | On Loan: —       |
| Kymera Therapeutics Inc            | Kymera Therapeutics Inc                                    | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    490849 | NS      | $21420650.36  | 0.44%             |  |  |  | No            |                  1 | On Loan: —       |
| Stoke Therapeutics Inc             | Stoke Therapeutics Inc                                     | CUSIP: 86150R107<br>LEI: 549300RD25SS2DIJHJ67 | Long             | EC               | CORP              | US        |    629238 | NS      | $7141851.30   | 0.15%             |  |  |  | No            |                  1 | On Loan: —       |
| Dynavax Technologies Corp          | Dynavax Technologies Corp                                  | CUSIP: 268158201<br>LEI: 549300T5URIXWDILX594 | Long             | EC               | CORP              | US        |   1989615 | NS      | $19736980.80  | 0.41%             |  |  |  | No            |                  1 | On Loan: —       |
| Arcellx Inc                        | Arcellx Inc                                                | CUSIP: 03940C100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    689342 | NS      | $45393170.70  | 0.94%             |  |  |  | No            |                  1 | On Loan: —       |
| Ardelyx Inc                        | Ardelyx Inc                                                | CUSIP: 039697107<br>LEI: 549300F542QR4SXHCY32 | Long             | EC               | CORP              | US        |   4396501 | NS      | $17234283.92  | 0.36%             |  |  |  | No            |                  1 | On Loan: —       |
| TG Therapeutics Inc                | TG Therapeutics Inc                                        | CUSIP: 88322Q108<br>LEI: 529900X21UKABN9NJ529 | Long             | EC               | CORP              | US        |   2301795 | NS      | $82841602.05  | 1.72%             |  |  |  | No            |                  1 | On Loan: —       |
| Sarepta Therapeutics Inc           | Sarepta Therapeutics Inc                                   | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |   1810561 | NS      | $30960593.10  | 0.64%             |  |  |  | No            |                  1 | On Loan: —       |
| Apogee Therapeutics Inc            | Apogee Therapeutics Inc                                    | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    516212 | NS      | $22419087.16  | 0.46%             |  |  |  | No            |                  1 | On Loan: —       |
| OMNIAB INC                         | OMNIAB INC                                                 | CUSIP: 68218J202<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    161959 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  3 | On Loan: —       |
| Ultragenyx Pharmaceutical Inc      | Ultragenyx Pharmaceutical Inc                              | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |    991713 | NS      | $36058684.68  | 0.75%             |  |  |  | No            |                  1 | On Loan: No      |
| Praxis Precision Medicines Inc     | Praxis Precision Medicines Inc                             | CUSIP: 74006W207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    303328 | NS      | $12754942.40  | 0.26%             |  |  |  | No            |                  1 | On Loan: —       |
| Insmed Inc                         | Insmed Inc                                                 | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |   1199732 | NS      | $120741028.48 | 2.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcus Biosciences Inc              | Arcus Biosciences Inc                                      | CUSIP: 03969F109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1206739 | NS      | $9822855.46   | 0.20%             |  |  |  | No            |                  1 | On Loan: —       |
| Arcutis Biotherapeutics Inc        | Arcutis Biotherapeutics Inc                                | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1887611 | NS      | $26464306.22  | 0.55%             |  |  |  | No            |                  1 | On Loan: —       |
| Vir Biotechnology Inc              | Vir Biotechnology Inc                                      | CUSIP: 92764N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1614546 | NS      | $8137311.84   | 0.17%             |  |  |  | No            |                  1 | On Loan: —       |
| Vericel Corp                       | Vericel Corp                                               | CUSIP: 92346J108<br>LEI: 54930076YM3PLTDR4B91 | Long             | EC               | CORP              | US        |    580548 | NS      | $24702317.40  | 0.51%             |  |  |  | No            |                  1 | On Loan: —       |
| Altimmune Inc                      | Altimmune Inc                                              | CUSIP: 02155H200<br>LEI: 549300EOYCQ8SW3NVE64 | Long             | EC               | CORP              | US        |   1247519 | NS      | $4827898.53   | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| Cogent Biosciences Inc             | Cogent Biosciences Inc                                     | CUSIP: 19240Q201<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1120988 | NS      | $8048693.84   | 0.17%             |  |  |  | No            |                  1 | On Loan: —       |
| Emergent BioSolutions Inc          | Emergent BioSolutions Inc                                  | CUSIP: 29089Q105<br>LEI: 549300YW6TUOX8BE5103 | Long             | EC               | CORP              | US        |    952721 | NS      | $6078359.98   | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Natera Inc                         | Natera Inc                                                 | CUSIP: 632307104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    705014 | NS      | $119105065.16 | 2.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences Inc         | Neurocrine Biosciences Inc                                 | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |    946735 | NS      | $118995122.15 | 2.46%             |  |  |  | No            |                  1 | On Loan: No      |
| Exelixis Inc                       | Exelixis Inc                                               | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |   2837606 | NS      | $125067484.45 | 2.59%             |  |  |  | No            |                  1 | On Loan: No      |
| Verastem Inc                       | Verastem Inc                                               | CUSIP: 92337C203<br>LEI: 549300IY0EFBIU8NQC81 | Long             | EC               | CORP              | US        |   1282287 | NS      | $5321491.05   | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| Crinetics Pharmaceuticals Inc      | Crinetics Pharmaceuticals Inc                              | CUSIP: 22663K107<br>LEI: 549300Q1CNFXK5P31D28 | Long             | EC               | CORP              | US        |   1109891 | NS      | $31920465.16  | 0.66%             |  |  |  | No            |                  1 | On Loan: —       |
| CG oncology Inc                    | CG oncology Inc                                            | CUSIP: 156944100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    981108 | NS      | $25508808.00  | 0.53%             |  |  |  | No            |                  1 | On Loan: —       |
| Cytokinetics Inc                   | Cytokinetics Inc                                           | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |   2072615 | NS      | $68479199.60  | 1.42%             |  |  |  | No            |                  1 | On Loan: —       |
| Regeneron Pharmaceuticals Inc      | Regeneron Pharmaceuticals Inc                              | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |    226717 | NS      | $119026425.00 | 2.46%             |  |  |  | No            |                  1 | On Loan: No      |
| Nurix Therapeutics Inc             | Nurix Therapeutics Inc                                     | CUSIP: 67080M103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    926047 | NS      | $10547675.33  | 0.22%             |  |  |  | No            |                  1 | On Loan: —       |
| Summit Therapeutics Inc            | Summit Therapeutics Inc                                    | CUSIP: 86627T108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2431833 | NS      | $51749406.24  | 1.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Syndax Pharmaceuticals Inc         | Syndax Pharmaceuticals Inc                                 | CUSIP: 87164F105<br>LEI: 529900OF94TRHKZVBS87 | Long             | EC               | CORP              | US        |   1541425 | NS      | $14435445.13  | 0.30%             |  |  |  | No            |                  1 | On Loan: —       |
| REGENXBIO Inc                      | REGENXBIO Inc                                              | CUSIP: 75901B107<br>LEI: 549300EOES47LATSET33 | Long             | EC               | CORP              | US        |    741803 | NS      | $6090202.63   | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Immunovant Inc                     | Immunovant Inc                                             | CUSIP: 45258J102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1301964 | NS      | $20831424.00  | 0.43%             |  |  |  | No            |                  1 | On Loan: —       |
| Day One Biopharmaceuticals Inc     | Day One Biopharmaceuticals Inc                             | CUSIP: 23954D109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1206791 | NS      | $7844141.50   | 0.16%             |  |  |  | No            |                  1 | On Loan: —       |
| Soleno Therapeutics Inc            | Soleno Therapeutics Inc                                    | CUSIP: 834203309<br>LEI: 5493003LCY77N7FXK844 | Long             | EC               | CORP              | US        |    579674 | NS      | $48565087.72  | 1.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Metsera Inc                        | Metsera Inc                                                | CUSIP: 59267L107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    235937 | NS      | $6712407.65   | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| Alkermes PLC                       | Alkermes PLC                                               | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | IE        |   1972254 | NS      | $56426186.94  | 1.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Amicus Therapeutics Inc            | Amicus Therapeutics Inc                                    | CUSIP: 03152W109<br>LEI: 549300MRD1SMUTNBPQ53 | Long             | EC               | CORP              | US        |   5075496 | NS      | $29082592.08  | 0.60%             |  |  |  | No            |                  1 | On Loan: No      |
| 89bio Inc                          | 89bio Inc                                                  | CUSIP: 282559103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1496343 | NS      | $14694088.26  | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Scholar Rock Holding Corp          | Scholar Rock Holding Corp                                  | CUSIP: 80706P103<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |   1221204 | NS      | $43255045.68  | 0.90%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC Therapeutics Inc               | PTC Therapeutics Inc                                       | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |   1193980 | NS      | $58313983.20  | 1.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Capricor Therapeutics Inc          | Capricor Therapeutics Inc                                  | CUSIP: 14070B309<br>LEI: 5493002ZI5PDLXV4DX14 | Long             | EC               | CORP              | US        |    586331 | NS      | $5822266.83   | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Novavax Inc                        | Novavax Inc                                                | CUSIP: 670002401<br>LEI: 529900J4GJHPEPQ23205 | Long             | EC               | CORP              | US        |   3106411 | NS      | $19570389.30  | 0.41%             |  |  |  | No            |                  1 | On Loan: —       |
| SpringWorks Therapeutics Inc       | SpringWorks Therapeutics Inc                               | CUSIP: 85205L107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1394246 | NS      | $65515619.54  | 1.36%             |  |  |  | No            |                  1 | On Loan: No      |
| uniQure NV                         | uniQure NV                                                 | CUSIP: 000000000<br>LEI: 724500RPCTZLFYJZ3S98 | Long             | EC               | CORP              | NL        |    841297 | NS      | $11727680.18  | 0.24%             |  |  |  | No            |                  1 | On Loan: —       |
| Mirum Pharmaceuticals Inc          | Mirum Pharmaceuticals Inc                                  | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |    454856 | NS      | $23147621.84  | 0.48%             |  |  |  | No            |                  1 | On Loan: No      |
| Roivant Sciences Ltd               | Roivant Sciences Ltd                                       | CUSIP: 000000000<br>LEI: 549300DL466NY5J6U724 | Long             | EC               | CORP              | BM        |   7226000 | NS      | $81437020.00  | 1.69%             |  |  |  | No            |                  1 | On Loan: —       |
| ARS Pharmaceuticals Inc            | ARS Pharmaceuticals Inc                                    | CUSIP: 82835W108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    988683 | NS      | $17252518.35  | 0.36%             |  |  |  | No            |                  1 | On Loan: —       |
| Xencor Inc                         | Xencor Inc                                                 | CUSIP: 98401F105<br>LEI: 549300V5IF65437JKG30 | Long             | EC               | CORP              | US        |   1107974 | NS      | $8708675.64   | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Gilead Sciences Inc                | Gilead Sciences Inc                                        | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |   1075615 | NS      | $119253435.05 | 2.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Janux Therapeutics Inc             | Janux Therapeutics Inc                                     | CUSIP: 47103J105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    573938 | NS      | $13257967.80  | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| MannKind Corp                      | MannKind Corp                                              | CUSIP: 56400P706<br>LEI: 213800GFBCNY1ZFST722 | Long             | EC               | CORP              | US        |   2877520 | NS      | $10761924.80  | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2025-07-29

**Name of Applicant:** SPDR SERIES TRUST

**Signature:** Arthur Jensen

**Name of Signer:** Arthur Jensen

**Title:** Deputy Treasurer