# EDGAR Filing Document

**Accession Number:** 0001906594
**File Stem:** 0001906594-26-000002
**Filing Date:** 2026-4
**Character Count:** 55975
**Document Hash:** b8897669e6fe9c2b8734d337b881fa3d
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001906594-26-000002.hdr.sgml**: 20260428

**ACCESSION NUMBER**: 0001906594-26-000002

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20260331

**FILED AS OF DATE**: 20260428

**DATE AS OF CHANGE**: 20260427

**EFFECTIVENESS DATE**: 20260428

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** China Universal Asset Management Co., Ltd.
- **CENTRAL INDEX KEY:** 0001906594

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** F4
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-21774
- **FILM NUMBER:** 26902908

**BUSINESS ADDRESS:**
- **STREET 1:** CUAM BUILDING,728 WAIMA ROAD
- **CITY:** SHANGHAI
- **STATE:** F4
- **ZIP:** 200001
- **BUSINESS PHONE:** 862128932888

**MAIL ADDRESS:**
- **STREET 1:** CUAM BUILDING,728 WAIMA ROAD
- **CITY:** SHANGHAI
- **STATE:** F4
- **ZIP:** 200001

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 03-31-2026

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** China Universal Asset Management Co. Ltd.<br>**Address:** CUAM BUILDING728 WAIMA ROAD<br>SHANGHAI, F4 200001

**Form 13F File Number:** 028-21774

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Li Peng<br>**Title:** Chief Compliance Officer<br>**Phone:** 011-86-21-20373399

**Signature, Place, and Date of Signing:**

Li Peng  Shanghai, F4  04-27-2026<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 502

**Form 13F Information Table Value Total:** $1320814008

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| NVIDIA CORP | Common Stock | 67066G104 |  | 80937655 | 464069 | SH |  | SOLE |  | 464069 | 0 | 0 |
| APPLE INC | Common Stock | 037833100 |  | 61972473 | 244188 | SH |  | SOLE |  | 244188 | 0 | 0 |
| MICROSOFT CORP | Common Stock | 594918104 |  | 49646830 | 134119 | SH |  | SOLE |  | 134119 | 0 | 0 |
| ALPHABET INC-CL A | Common Stock | 02079K305 |  | 48822224 | 169781 | SH |  | SOLE |  | 169781 | 0 | 0 |
| AMAZON.COM INC | Common Stock | 023135106 |  | 42299637 | 203100 | SH |  | SOLE |  | 203100 | 0 | 0 |
| ISHARES GOLD TRUST | ETP | 464285204 |  | 34729750 | 393940 | SH |  | SOLE |  | 393940 | 0 | 0 |
| SPDR GOLD SHARES | ETP | 78463V107 |  | 33067787 | 76850 | SH |  | SOLE |  | 76850 | 0 | 0 |
| SPDR GOLD MINISHARES TRUST | ETP | 98149E303 |  | 32413693 | 349700 | SH |  | SOLE |  | 349700 | 0 | 0 |
| META PLATFORMS INC-CLASS A | Common Stock | 30303M102 |  | 30635845 | 53547 | SH |  | SOLE |  | 53547 | 0 | 0 |
| BROADCOM INC | Common Stock | 11135F101 |  | 30069206 | 97151 | SH |  | SOLE |  | 97151 | 0 | 0 |
| TESLA INC | Common Stock | 88160R101 |  | 22567827 | 60707 | SH |  | SOLE |  | 60707 | 0 | 0 |
| AMGEN INC | Common Stock | 031162100 |  | 21958959 | 62410 | SH |  | SOLE |  | 62410 | 0 | 0 |
| GILEAD SCIENCES INC | Common Stock | 375558103 |  | 21953981 | 157523 | SH |  | SOLE |  | 157523 | 0 | 0 |
| ALPHABET INC-CL C | Common Stock | 02079K107 |  | 20238834 | 70553 | SH |  | SOLE |  | 70553 | 0 | 0 |
| VERTEX PHARMACEUTICALS INC | Common Stock | 92532F100 |  | 19603999 | 43902 | SH |  | SOLE |  | 43902 | 0 | 0 |
| NETFLIX INC | Common Stock | 64110L106 |  | 19262403 | 200337 | SH |  | SOLE |  | 200337 | 0 | 0 |
| WALMART INC | Common Stock | 931142103 |  | 18669544 | 149962 | SH |  | SOLE |  | 149962 | 0 | 0 |
| MICRON TECHNOLOGY INC | Common Stock | 595112103 |  | 18352583 | 54302 | SH |  | SOLE |  | 54302 | 0 | 0 |
| REGENERON PHARMACEUTICALS | Common Stock | 75886F107 |  | 16504363 | 21361 | SH |  | SOLE |  | 21361 | 0 | 0 |
| COSTCO WHOLESALE CORP | Common Stock | 22160K105 |  | 15859180 | 15916 | SH |  | SOLE |  | 15916 | 0 | 0 |
| ADVANCED MICRO DEVICES | Common Stock | 007903107 |  | 15786168 | 77600 | SH |  | SOLE |  | 77600 | 0 | 0 |
| ISHARES GOLD TRUST MICRO | ETP | 46436F103 |  | 15551100 | 333000 | SH |  | SOLE |  | 333000 | 0 | 0 |
| GRANITESHARES GOLD TRUST | ETP | 38748G101 |  | 13977390 | 303000 | SH |  | SOLE |  | 303000 | 0 | 0 |
| PALANTIR TECHNOLOGIES INC-A | Common Stock | 69608A108 |  | 13825654 | 94515 | SH |  | SOLE |  | 94515 | 0 | 0 |
| LAM RESEARCH CORP | Common Stock | 512807306 |  | 13014895 | 60848 | SH |  | SOLE |  | 60848 | 0 | 0 |
| APPLIED MATERIALS INC | Common Stock | 038222105 |  | 12742957 | 37283 | SH |  | SOLE |  | 37283 | 0 | 0 |
| PROSHARES ULTRA GOLD | ETP | 74347W601 |  | 12617738 | 205300 | SH |  | SOLE |  | 205300 | 0 | 0 |
| ABRDN PHYSICAL GOLD SHARES | ETP | 00326A104 |  | 12337430 | 276500 | SH |  | SOLE |  | 276500 | 0 | 0 |
| CISCO SYSTEMS INC | Common Stock | 17275R102 |  | 11783050 | 151863 | SH |  | SOLE |  | 151863 | 0 | 0 |
| GOLDMAN SACHS PHYSICAL GOLD | ETP | 38150K103 |  | 11177980 | 242000 | SH |  | SOLE |  | 242000 | 0 | 0 |
| ANALOG DEVICES INC | Common Stock | 032654105 |  | 10461398 | 32883 | SH |  | SOLE |  | 32883 | 0 | 0 |
| INTEL CORP | Common Stock | 458140100 |  | 9946019 | 225380 | SH |  | SOLE |  | 225380 | 0 | 0 |
| KLA CORP | Common Stock | 482480100 |  | 9890178 | 6717 | SH |  | SOLE |  | 6717 | 0 | 0 |
| TAIWAN SEMICONDUCTOR-SP ADR | ADR | 874039100 |  | 9803139 | 28943 | SH |  | SOLE |  | 28943 | 0 | 0 |
| ALNYLAM PHARMACEUTICALS INC | Common Stock | 02043Q107 |  | 9021501 | 27266 | SH |  | SOLE |  | 27266 | 0 | 0 |
| NOVARTIS AG-SPONSORED ADR | ADR | 66987V109 |  | 8116371 | 53135 | SH |  | SOLE |  | 53135 | 0 | 0 |
| INSMED INC | Common Stock | 457669307 |  | 7687893 | 47015 | SH |  | SOLE |  | 47015 | 0 | 0 |
| LINDE PLC | Common Stock | G54950103 |  | 7121592 | 14365 | SH |  | SOLE |  | 14365 | 0 | 0 |
| JOHNSON  JOHNSON | Common Stock | 478160104 |  | 6956762 | 28460 | SH |  | SOLE |  | 28460 | 0 | 0 |
| PALO ALTO NETWORKS INC | Common Stock | 697435105 |  | 6669953 | 41604 | SH |  | SOLE |  | 41604 | 0 | 0 |
| SHOPIFY INC - CLASS A | Common Stock | 82509L107 |  | 6665139 | 56189 | SH |  | SOLE |  | 56189 | 0 | 0 |
| PEPSICO INC | Common Stock | 713448108 |  | 6574513 | 42337 | SH |  | SOLE |  | 42337 | 0 | 0 |
| T-MOBILE US INC | Common Stock | 872590104 |  | 6510090 | 30996 | SH |  | SOLE |  | 30996 | 0 | 0 |
| VISA INC-CLASS A SHARES | Common Stock | 92826C839 |  | 6392376 | 21150 | SH |  | SOLE |  | 21150 | 0 | 0 |
| LUMENTUM HOLDINGS INC | Common Stock | 55024U109 |  | 6299541 | 8964 | SH |  | SOLE |  | 8964 | 0 | 0 |
| WESTERN DIGITAL CORP | Common Stock | 958102105 |  | 6258327 | 23137 | SH |  | SOLE |  | 23137 | 0 | 0 |
| ROYALTY PHARMA PLC- CL A | Common Stock | G7709Q104 |  | 6257543 | 130447 | SH |  | SOLE |  | 130447 | 0 | 0 |
| BOOKING HOLDINGS INC | Common Stock | 09857L108 |  | 6235484 | 1481 | SH |  | SOLE |  | 1481 | 0 | 0 |
| INTUITIVE SURGICAL INC | Common Stock | 46120E602 |  | 6080458 | 13190 | SH |  | SOLE |  | 13190 | 0 | 0 |
| APPLOVIN CORP-CLASS A | Common Stock | 03831W108 |  | 6044824 | 15188 | SH |  | SOLE |  | 15188 | 0 | 0 |
| TEXAS INSTRUMENTS INC | Common Stock | 882508104 |  | 5808086 | 29917 | SH |  | SOLE |  | 29917 | 0 | 0 |
| IONIS PHARMACEUTICALS INC | Common Stock | 462222100 |  | 5805583 | 77315 | SH |  | SOLE |  | 77315 | 0 | 0 |
| INTUIT INC | Common Stock | 461202103 |  | 5402156 | 12494 | SH |  | SOLE |  | 12494 | 0 | 0 |
| ASML HOLDING NV-NY REG SHS | NY Reg Shrs | N07059210 |  | 5145954 | 3896 | SH |  | SOLE |  | 3896 | 0 | 0 |
| ASTRAZENECA PLC | Common Stock | G0593M107 |  | 5048832 | 25600 | SH |  | SOLE |  | 25600 | 0 | 0 |
| BRITISH AMERICAN TOB-SP ADR | ADR | 110448107 |  | 4880026 | 82301 | SH |  | SOLE |  | 82301 | 0 | 0 |
| BIOGEN INC | Common Stock | 09062X103 |  | 4774647 | 26044 | SH |  | SOLE |  | 26044 | 0 | 0 |
| UNITED THERAPEUTICS CORP | Common Stock | 91307C102 |  | 4612198 | 7778 | SH |  | SOLE |  | 7778 | 0 | 0 |
| MASTERCARD INC - A | Common Stock | 57636Q104 |  | 4312565 | 8631 | SH |  | SOLE |  | 8631 | 0 | 0 |
| HOME DEPOT INC | Common Stock | 437076102 |  | 4273597 | 12994 | SH |  | SOLE |  | 12994 | 0 | 0 |
| SYNOPSYS INC | Common Stock | 871607107 |  | 4143612 | 10451 | SH |  | SOLE |  | 10451 | 0 | 0 |
| QUALCOMM INC | Common Stock | 747525103 |  | 4122892 | 32015 | SH |  | SOLE |  | 32015 | 0 | 0 |
| HONEYWELL INTERNATIONAL INC | Common Stock | 438516106 |  | 4041868 | 17882 | SH |  | SOLE |  | 17882 | 0 | 0 |
| ELI LILLY  CO | Common Stock | 532457108 |  | 3943974 | 4288 | SH |  | SOLE |  | 4288 | 0 | 0 |
| CROWDSTRIKE HOLDINGS INC - A | Common Stock | 22788C105 |  | 3764333 | 9642 | SH |  | SOLE |  | 9642 | 0 | 0 |
| COCA-COLA CO/THE | Common Stock | 191216100 |  | 3763336 | 49419 | SH |  | SOLE |  | 49419 | 0 | 0 |
| ARGENX SE - ADR | ADR | 04016X101 |  | 3676809 | 5035 | SH |  | SOLE |  | 5035 | 0 | 0 |
| MODERNA INC | Common Stock | 60770K107 |  | 3560318 | 70085 | SH |  | SOLE |  | 70085 | 0 | 0 |
| ROIVANT SCIENCES LTD | Common Stock | G76279101 |  | 3518094 | 127007 | SH |  | SOLE |  | 127007 | 0 | 0 |
| REVOLUTION MEDICINES INC | Common Stock | 76155X100 |  | 3419991 | 35167 | SH |  | SOLE |  | 35167 | 0 | 0 |
| INCYTE CORP | Common Stock | 45337C102 |  | 3324036 | 35317 | SH |  | SOLE |  | 35317 | 0 | 0 |
| PDD HOLDINGS INC | ADR | 722304102 |  | 3319726 | 32489 | SH |  | SOLE |  | 32489 | 0 | 0 |
| MERCADOLIBRE INC | Common Stock | 58733R102 |  | 3226351 | 1866 | SH |  | SOLE |  | 1866 | 0 | 0 |
| SANDISK CORP | Common Stock | 80004C200 |  | 3176700 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| CADENCE DESIGN SYS INC | Common Stock | 127387108 |  | 3102974 | 11167 | SH |  | SOLE |  | 11167 | 0 | 0 |
| COHERENT CORP | Common Stock | 19247G107 |  | 2980960 | 12514 | SH |  | SOLE |  | 12514 | 0 | 0 |
| COMCAST CORP-CLASS A | Common Stock | 20030N101 |  | 2898074 | 100943 | SH |  | SOLE |  | 100943 | 0 | 0 |
| STARBUCKS CORP | Common Stock | 855244109 |  | 2879871 | 32145 | SH |  | SOLE |  | 32145 | 0 | 0 |
| DOORDASH INC - A | Common Stock | 25809K105 |  | 2865312 | 19083 | SH |  | SOLE |  | 19083 | 0 | 0 |
| CONSTELLATION ENERGY | Common Stock | 21037T109 |  | 2843603 | 10183 | SH |  | SOLE |  | 10183 | 0 | 0 |
| AUTODESK INC | Common Stock | 052769106 |  | 2840242 | 11864 | SH |  | SOLE |  | 11864 | 0 | 0 |
| ADOBE INC | Common Stock | 00724F101 |  | 2787398 | 11467 | SH |  | SOLE |  | 11467 | 0 | 0 |
| MCDONALD'S CORP | Common Stock | 580135101 |  | 2785611 | 8963 | SH |  | SOLE |  | 8963 | 0 | 0 |
| VIATRIS INC | Common Stock | 92556V106 |  | 2760417 | 204324 | SH |  | SOLE |  | 204324 | 0 | 0 |
| AMPHENOL CORP-CL A | Common Stock | 032095101 |  | 2683390 | 21200 | SH |  | SOLE |  | 21200 | 0 | 0 |
| TERADYNE INC | Common Stock | 880770102 |  | 2638494 | 8900 | SH |  | SOLE |  | 8900 | 0 | 0 |
| FERRARI NV | Common Stock | N3167Y103 |  | 2624003 | 7753 | SH |  | SOLE |  | 7753 | 0 | 0 |
| SUMMIT THERAPEUTICS INC | Common Stock | 86627T108 |  | 2608820 | 137596 | SH |  | SOLE |  | 137596 | 0 | 0 |
| BRIDGEBIO PHARMA INC | Common Stock | 10806X102 |  | 2554767 | 34403 | SH |  | SOLE |  | 34403 | 0 | 0 |
| ASCENDIS PHARMA A/S | ADR | 04351P101 |  | 2498875 | 10925 | SH |  | SOLE |  | 10925 | 0 | 0 |
| PETROLEO BRASILEIRO-SPON ADR | ADR | 71654V408 |  | 2494150 | 120200 | SH |  | SOLE |  | 120200 | 0 | 0 |
| ALIBABA GROUP HOLDING-SP ADR | ADR | 01609W102 |  | 2450234 | 19530 | SH |  | SOLE |  | 19530 | 0 | 0 |
| MARRIOTT INTERNATIONAL -CL A | Common Stock | 571903202 |  | 2437980 | 7454 | SH |  | SOLE |  | 7454 | 0 | 0 |
| MARVELL TECHNOLOGY INC | Common Stock | 573874104 |  | 2427418 | 24507 | SH |  | SOLE |  | 24507 | 0 | 0 |
| MEDPACE HOLDINGS INC | Common Stock | 58506Q109 |  | 2418237 | 5036 | SH |  | SOLE |  | 5036 | 0 | 0 |
| SEAGATE TECHNOLOGY HOLDINGS | Common Stock | G7997R103 |  | 2406367 | 6134 | SH |  | SOLE |  | 6134 | 0 | 0 |
| NEUROCRINE BIOSCIENCES INC | Common Stock | 64125C109 |  | 2346289 | 17810 | SH |  | SOLE |  | 17810 | 0 | 0 |
| VERTIV HOLDINGS CO-A | Common Stock | 92537N108 |  | 2323127 | 9271 | SH |  | SOLE |  | 9271 | 0 | 0 |
| AUTOMATIC DATA PROCESSING | Common Stock | 053015103 |  | 2318331 | 11327 | SH |  | SOLE |  | 11327 | 0 | 0 |
| JPMORGAN CHASE  CO | Common Stock | 46625H100 |  | 2280328 | 7752 | SH |  | SOLE |  | 7752 | 0 | 0 |
| UBER TECHNOLOGIES INC | Common Stock | 90353T100 |  | 2244216 | 31200 | SH |  | SOLE |  | 31200 | 0 | 0 |
| MADRIGAL PHARMACEUTICALS INC | Common Stock | 558868105 |  | 2235740 | 4271 | SH |  | SOLE |  | 4271 | 0 | 0 |
| O'REILLY AUTOMOTIVE INC | Common Stock | 67103H107 |  | 2177316 | 23587 | SH |  | SOLE |  | 23587 | 0 | 0 |
| GUARDANT HEALTH INC | Common Stock | 40131M109 |  | 2150096 | 23277 | SH |  | SOLE |  | 23277 | 0 | 0 |
| CSX CORP | Common Stock | 126408103 |  | 2147326 | 52310 | SH |  | SOLE |  | 52310 | 0 | 0 |
| TJX COMPANIES INC | Common Stock | 872540109 |  | 2108040 | 13200 | SH |  | SOLE |  | 13200 | 0 | 0 |
| MONDELEZ INTERNATIONAL INC-A | Common Stock | 609207105 |  | 2094220 | 36059 | SH |  | SOLE |  | 36059 | 0 | 0 |
| SANOFI-ADR | ADR | 80105N105 |  | 2092602 | 43433 | SH |  | SOLE |  | 43433 | 0 | 0 |
| JAZZ PHARMACEUTICALS PLC | Common Stock | G50871105 |  | 2065182 | 10924 | SH |  | SOLE |  | 10924 | 0 | 0 |
| EXXON MOBIL CORP | Common Stock | 30231G102 |  | 2037277 | 12008 | SH |  | SOLE |  | 12008 | 0 | 0 |
| AMERICAN ELECTRIC POWER | Common Stock | 025537101 |  | 1994382 | 15215 | SH |  | SOLE |  | 15215 | 0 | 0 |
| MONSTER BEVERAGE CORP | Common Stock | 61174X109 |  | 1994027 | 27519 | SH |  | SOLE |  | 27519 | 0 | 0 |
| DATADOG INC - CLASS A | Common Stock | 23804L103 |  | 1987962 | 16840 | SH |  | SOLE |  | 16840 | 0 | 0 |
| EXELIXIS INC | Common Stock | 30161Q104 |  | 1976671 | 46087 | SH |  | SOLE |  | 46087 | 0 | 0 |
| ROSS STORES INC | Common Stock | 778296103 |  | 1971116 | 9099 | SH |  | SOLE |  | 9099 | 0 | 0 |
| BIOMARIN PHARMACEUTICAL INC | Common Stock | 09061G101 |  | 1927947 | 34129 | SH |  | SOLE |  | 34129 | 0 | 0 |
| WARNER BROS DISCOVERY INC | Common Stock | 934423104 |  | 1915637 | 69761 | SH |  | SOLE |  | 69761 | 0 | 0 |
| CINTAS CORP | Common Stock | 172908105 |  | 1902656 | 11249 | SH |  | SOLE |  | 11249 | 0 | 0 |
| BERKSHIRE HATHAWAY INC-CL B | Common Stock | 084670702 |  | 1877026 | 3917 | SH |  | SOLE |  | 3917 | 0 | 0 |
| NETEASE INC-ADR | ADR | 64110W102 |  | 1858204 | 16600 | SH |  | SOLE |  | 16600 | 0 | 0 |
| CELESTICA INC | Common Stock | 15101Q207 |  | 1802752 | 6400 | SH |  | SOLE |  | 6400 | 0 | 0 |
| BIONTECH SE-ADR | ADR | 09075V102 |  | 1798042 | 20230 | SH |  | SOLE |  | 20230 | 0 | 0 |
| MICROCHIP TECHNOLOGY INC | Common Stock | 595017104 |  | 1758813 | 27222 | SH |  | SOLE |  | 27222 | 0 | 0 |
| TTM TECHNOLOGIES | Common Stock | 87305R109 |  | 1753560 | 18000 | SH |  | SOLE |  | 18000 | 0 | 0 |
| PACCAR INC | Common Stock | 693718108 |  | 1708707 | 14794 | SH |  | SOLE |  | 14794 | 0 | 0 |
| FORTINET INC | Common Stock | 34959E109 |  | 1700920 | 20814 | SH |  | SOLE |  | 20814 | 0 | 0 |
| BAKER HUGHES CO | Common Stock | 05722G100 |  | 1697190 | 27800 | SH |  | SOLE |  | 27800 | 0 | 0 |
| BEONE MEDICINES LTD-ADR | ADR | 07725L102 |  | 1684414 | 5672 | SH |  | SOLE |  | 5672 | 0 | 0 |
| MONOLITHIC POWER SYSTEMS INC | Common Stock | 609839105 |  | 1622944 | 1482 | SH |  | SOLE |  | 1482 | 0 | 0 |
| PRAXIS PRECISION MEDICINES I | Common Stock | 74006W207 |  | 1592263 | 4942 | SH |  | SOLE |  | 4942 | 0 | 0 |
| THERMO FISHER SCIENTIFIC INC | Common Stock | 883556102 |  | 1574250 | 3200 | SH |  | SOLE |  | 3200 | 0 | 0 |
| PROTAGONIST THERAPEUTICS INC | Common Stock | 74366E102 |  | 1572884 | 14923 | SH |  | SOLE |  | 14923 | 0 | 0 |
| DIAMONDBACK ENERGY INC | Common Stock | 25278X109 |  | 1569464 | 7935 | SH |  | SOLE |  | 7935 | 0 | 0 |
| BOSTON SCIENTIFIC CORP | Common Stock | 101137107 |  | 1568750 | 25000 | SH |  | SOLE |  | 25000 | 0 | 0 |
| ARROWHEAD PHARMACEUTICALS IN | Common Stock | 04280A100 |  | 1558095 | 24850 | SH |  | SOLE |  | 24850 | 0 | 0 |
| AXSOME THERAPEUTICS INC | Common Stock | 05464T104 |  | 1534364 | 9078 | SH |  | SOLE |  | 9078 | 0 | 0 |
| AIRBNB INC-CLASS A | Common Stock | 009066101 |  | 1504626 | 11915 | SH |  | SOLE |  | 11915 | 0 | 0 |
| STRYKER CORP | Common Stock | 863667101 |  | 1504288 | 4567 | SH |  | SOLE |  | 4567 | 0 | 0 |
| FASTENAL CO | Common Stock | 311900104 |  | 1498859 | 32303 | SH |  | SOLE |  | 32303 | 0 | 0 |
| VAXCYTE INC | Common Stock | 92243G108 |  | 1484129 | 25540 | SH |  | SOLE |  | 25540 | 0 | 0 |
| FUTU HOLDINGS LTD-ADR | ADR | 36118L106 |  | 1477008 | 10800 | SH |  | SOLE |  | 10800 | 0 | 0 |
| TRANSOCEAN LTD | Common Stock | H8817H100 |  | 1471197 | 221900 | SH |  | SOLE |  | 221900 | 0 | 0 |
| TOWER SEMICONDUCTOR LTD | Common Stock | M87915274 |  | 1462977 | 8337 | SH |  | SOLE |  | 8337 | 0 | 0 |
| TAL EDUCATION GROUP- ADR | ADR | 874080104 |  | 1443990 | 127000 | SH |  | SOLE |  | 127000 | 0 | 0 |
| CYTOKINETICS INC | Common Stock | 23282W605 |  | 1440529 | 21856 | SH |  | SOLE |  | 21856 | 0 | 0 |
| ABIVAX SA-ADR | ADR | 00370M103 |  | 1436749 | 12903 | SH |  | SOLE |  | 12903 | 0 | 0 |
| ELECTRONIC ARTS INC | Common Stock | 285512109 |  | 1435245 | 7040 | SH |  | SOLE |  | 7040 | 0 | 0 |
| EXELON CORP | Common Stock | 30161N101 |  | 1410501 | 28774 | SH |  | SOLE |  | 28774 | 0 | 0 |
| ASE TECHNOLOGY HOLDING -ADR | ADR | 00215W100 |  | 1409200 | 65000 | SH |  | SOLE |  | 65000 | 0 | 0 |
| NXP SEMICONDUCTORS NV | Common Stock | N6596X109 |  | 1405239 | 7108 | SH |  | SOLE |  | 7108 | 0 | 0 |
| XCEL ENERGY INC | Common Stock | 98389B100 |  | 1402793 | 17550 | SH |  | SOLE |  | 17550 | 0 | 0 |
| IMMUNITYBIO INC | Common Stock | 45256X103 |  | 1399368 | 182447 | SH |  | SOLE |  | 182447 | 0 | 0 |
| NEWAMSTERDAM PHARMA CO NV | Common Stock | N62509109 |  | 1398933 | 43703 | SH |  | SOLE |  | 43703 | 0 | 0 |
| TEMPUS AI INC-CL A | Common Stock | 88023B103 |  | 1394133 | 30830 | SH |  | SOLE |  | 30830 | 0 | 0 |
| MCKESSON CORP | Common Stock | 58155Q103 |  | 1386052 | 1600 | SH |  | SOLE |  | 1600 | 0 | 0 |
| HALOZYME THERAPEUTICS INC | Common Stock | 40637H109 |  | 1353546 | 20943 | SH |  | SOLE |  | 20943 | 0 | 0 |
| KRYSTAL BIOTECH INC | Common Stock | 501147102 |  | 1339906 | 5187 | SH |  | SOLE |  | 5187 | 0 | 0 |
| NUVALENT INC-A | Common Stock | 670703107 |  | 1330518 | 12987 | SH |  | SOLE |  | 12987 | 0 | 0 |
| CIENA CORP | Common Stock | 171779309 |  | 1319982 | 3400 | SH |  | SOLE |  | 3400 | 0 | 0 |
| FERROVIAL SE | Common Stock | N3168P101 |  | 1316547 | 20239 | SH |  | SOLE |  | 20239 | 0 | 0 |
| BRISTOL-MYERS SQUIBB CO | Common Stock | 110122108 |  | 1310040 | 21600 | SH |  | SOLE |  | 21600 | 0 | 0 |
| ATOUR LIFESTYLE HOLDINGS-ADR | ADR | 04965M106 |  | 1306755 | 35500 | SH |  | SOLE |  | 35500 | 0 | 0 |
| REDDIT INC-CL A | Common Stock | 75734B100 |  | 1292640 | 9600 | SH |  | SOLE |  | 9600 | 0 | 0 |
| KEYSIGHT TECHNOLOGIES IN | Common Stock | 49338L103 |  | 1270665 | 4500 | SH |  | SOLE |  | 4500 | 0 | 0 |
| IDEXX LABORATORIES INC | Common Stock | 45168D104 |  | 1258634 | 2240 | SH |  | SOLE |  | 2240 | 0 | 0 |
| TENET HEALTHCARE CORP | Common Stock | 88033G407 |  | 1207744 | 6400 | SH |  | SOLE |  | 6400 | 0 | 0 |
| KYMERA THERAPEUTICS INC | Common Stock | 501575104 |  | 1206706 | 14488 | SH |  | SOLE |  | 14488 | 0 | 0 |
| ARCELLX INC | Common Stock | 03940C100 |  | 1191602 | 10378 | SH |  | SOLE |  | 10378 | 0 | 0 |
| SPOTIFY TECHNOLOGY SA | Common Stock | L8681T102 |  | 1188030 | 2450 | SH |  | SOLE |  | 2450 | 0 | 0 |
| PAYPAL HOLDINGS INC | Common Stock | 70450Y103 |  | 1171412 | 25899 | SH |  | SOLE |  | 25899 | 0 | 0 |
| TWILIO INC - A | Common Stock | 90138F102 |  | 1170126 | 9300 | SH |  | SOLE |  | 9300 | 0 | 0 |
| COCA-COLA EUROPACIFIC PARTNE | Common Stock | G25839104 |  | 1168646 | 12889 | SH |  | SOLE |  | 12889 | 0 | 0 |
| CVS HEALTH CORP | Common Stock | 126650100 |  | 1149120 | 16000 | SH |  | SOLE |  | 16000 | 0 | 0 |
| OLD DOMINION FREIGHT LINE | Common Stock | 679580100 |  | 1145630 | 5863 | SH |  | SOLE |  | 5863 | 0 | 0 |
| VENTURE GLOBAL INC-CL A | Common Stock | 92333F101 |  | 1134720 | 72000 | SH |  | SOLE |  | 72000 | 0 | 0 |
| CHEVRON CORP | Common Stock | 166764100 |  | 1126984 | 5447 | SH |  | SOLE |  | 5447 | 0 | 0 |
| THOMSON REUTERS CORP | Common Stock | 884903808 |  | 1126010 | 12514 | SH |  | SOLE |  | 12514 | 0 | 0 |
| SEA LTD-ADR | ADR | 81141R100 |  | 1111393 | 13421 | SH |  | SOLE |  | 13421 | 0 | 0 |
| COGENT BIOSCIENCES INC | Common Stock | 19240Q201 |  | 1108627 | 28803 | SH |  | SOLE |  | 28803 | 0 | 0 |
| STRATEGY INC | Common Stock | 594972408 |  | 1102733 | 8836 | SH |  | SOLE |  | 8836 | 0 | 0 |
| ABBVIE INC | Common Stock | 00287Y109 |  | 1094627 | 5033 | SH |  | SOLE |  | 5033 | 0 | 0 |
| TRIP.COM GROUP LTD-ADR | ADR | 89677Q107 |  | 1070485 | 21500 | SH |  | SOLE |  | 21500 | 0 | 0 |
| PROCTER  GAMBLE CO/THE | Common Stock | 742718109 |  | 1068134 | 7395 | SH |  | SOLE |  | 7395 | 0 | 0 |
| RHYTHM PHARMACEUTICALS INC | Common Stock | 76243J105 |  | 1053902 | 12118 | SH |  | SOLE |  | 12118 | 0 | 0 |
| ALKERMES PLC | Common Stock | G01767105 |  | 1045701 | 29573 | SH |  | SOLE |  | 29573 | 0 | 0 |
| TAKE-TWO INTERACTIVE SOFTWRE | Common Stock | 874054109 |  | 1028778 | 5209 | SH |  | SOLE |  | 5209 | 0 | 0 |
| ROPER TECHNOLOGIES INC | Common Stock | 776696106 |  | 1024425 | 2895 | SH |  | SOLE |  | 2895 | 0 | 0 |
| CG ONCOLOGY INC | Common Stock | 156944100 |  | 1014117 | 14984 | SH |  | SOLE |  | 14984 | 0 | 0 |
| KEURIG DR PEPPER INC | Common Stock | 49271V100 |  | 1014026 | 38220 | SH |  | SOLE |  | 38220 | 0 | 0 |
| PTC THERAPEUTICS INC | Common Stock | 69366J200 |  | 1000762 | 14689 | SH |  | SOLE |  | 14689 | 0 | 0 |
| TERNS PHARMACEUTICALS INC | Common Stock | 880881107 |  | 994774 | 18869 | SH |  | SOLE |  | 18869 | 0 | 0 |
| MIRUM PHARMACEUTICALS INC | Common Stock | 604749101 |  | 989205 | 10708 | SH |  | SOLE |  | 10708 | 0 | 0 |
| ABBOTT LABORATORIES | Common Stock | 002824100 |  | 977213 | 9518 | SH |  | SOLE |  | 9518 | 0 | 0 |
| AXON ENTERPRISE INC | Common Stock | 05464C101 |  | 960649 | 2262 | SH |  | SOLE |  | 2262 | 0 | 0 |
| BANK OF AMERICA CORP | Common Stock | 060505104 |  | 951161 | 19511 | SH |  | SOLE |  | 19511 | 0 | 0 |
| CATERPILLAR INC | Common Stock | 149123101 |  | 944377 | 1333 | SH |  | SOLE |  | 1333 | 0 | 0 |
| UNITY SOFTWARE INC | Common Stock | 91332U101 |  | 943420 | 43000 | SH |  | SOLE |  | 43000 | 0 | 0 |
| ZSCALER INC | Common Stock | 98980G102 |  | 943170 | 6723 | SH |  | SOLE |  | 6723 | 0 | 0 |
| IMMUNOVANT INC | Common Stock | 45258J102 |  | 936915 | 37718 | SH |  | SOLE |  | 37718 | 0 | 0 |
| PAYCHEX INC | Common Stock | 704326107 |  | 930228 | 10098 | SH |  | SOLE |  | 10098 | 0 | 0 |
| CLOUDFLARE INC - CLASS A | Common Stock | 18915M107 |  | 928530 | 4500 | SH |  | SOLE |  | 4500 | 0 | 0 |
| APELLIS PHARMACEUTICALS INC | Common Stock | 03753U106 |  | 912577 | 22684 | SH |  | SOLE |  | 22684 | 0 | 0 |
| GE HEALTHCARE TECHNOLOGY | Common Stock | 36266G107 |  | 912528 | 12820 | SH |  | SOLE |  | 12820 | 0 | 0 |
| COPART INC | Common Stock | 217204106 |  | 904069 | 27231 | SH |  | SOLE |  | 27231 | 0 | 0 |
| CARIS LIFE SCIENCES INC | Common Stock | 142152107 |  | 895234 | 50069 | SH |  | SOLE |  | 50069 | 0 | 0 |
| SCHOLAR ROCK HOLDING CORP | Common Stock | 80706P103 |  | 889894 | 18102 | SH |  | SOLE |  | 18102 | 0 | 0 |
| GSK PLC-SPON ADR | ADR | 37733W204 |  | 889016 | 16000 | SH |  | SOLE |  | 16000 | 0 | 0 |
| ERASCA INC | Common Stock | 29479A108 |  | 888913 | 54939 | SH |  | SOLE |  | 54939 | 0 | 0 |
| MERCK  CO. INC. | Common Stock | 58933Y105 |  | 861806 | 7068 | SH |  | SOLE |  | 7068 | 0 | 0 |
| XENON PHARMACEUTICALS INC | Common Stock | 98420N105 |  | 858468 | 14763 | SH |  | SOLE |  | 14763 | 0 | 0 |
| GENERAL ELECTRIC | Common Stock | 369604301 |  | 853594 | 3004 | SH |  | SOLE |  | 3004 | 0 | 0 |
| CENTESSA PHARMACEUTICALS-ADR | ADR | 152309100 |  | 843057 | 21225 | SH |  | SOLE |  | 21225 | 0 | 0 |
| COGNIZANT TECH SOLUTIONS-A | Common Stock | 192446102 |  | 825342 | 13453 | SH |  | SOLE |  | 13453 | 0 | 0 |
| APOGEE THERAPEUTICS INC | Common Stock | 03770N101 |  | 819058 | 9731 | SH |  | SOLE |  | 9731 | 0 | 0 |
| CRISPR THERAPEUTICS AG | Common Stock | H17182108 |  | 810260 | 17033 | SH |  | SOLE |  | 17033 | 0 | 0 |
| DEXCOM INC | Common Stock | 252131107 |  | 805473 | 12826 | SH |  | SOLE |  | 12826 | 0 | 0 |
| KANZHUN LTD - ADR | ADR | 48553T106 |  | 803400 | 60000 | SH |  | SOLE |  | 60000 | 0 | 0 |
| EDGEWISE THERAPEUTICS INC | Common Stock | 28036F105 |  | 801234 | 25436 | SH |  | SOLE |  | 25436 | 0 | 0 |
| THE CIGNA GROUP | Common Stock | 125523100 |  | 800250 | 3000 | SH |  | SOLE |  | 3000 | 0 | 0 |
| DENALI THERAPEUTICS INC | Common Stock | 24823R105 |  | 780346 | 40643 | SH |  | SOLE |  | 40643 | 0 | 0 |
| WORKDAY INC-CLASS A | Common Stock | 98138H101 |  | 778481 | 5992 | SH |  | SOLE |  | 5992 | 0 | 0 |
| CHARTER COMMUNICATIONS INC-A | Common Stock | 16119P108 |  | 768965 | 3562 | SH |  | SOLE |  | 3562 | 0 | 0 |
| KRAFT HEINZ CO/THE | Common Stock | 500754106 |  | 748895 | 33299 | SH |  | SOLE |  | 33299 | 0 | 0 |
| PHILIP MORRIS INTERNATIONAL | Common Stock | 718172109 |  | 738257 | 4433 | SH |  | SOLE |  | 4433 | 0 | 0 |
| RTX CORP | Common Stock | 75513E101 |  | 736492 | 3818 | SH |  | SOLE |  | 3818 | 0 | 0 |
| VERISK ANALYTICS INC | Common Stock | 92345Y106 |  | 736230 | 3880 | SH |  | SOLE |  | 3880 | 0 | 0 |
| GOLDMAN SACHS GROUP INC | Common Stock | 38141G104 |  | 722475 | 854 | SH |  | SOLE |  | 854 | 0 | 0 |
| ORACLE CORP | Common Stock | 68389X105 |  | 722163 | 4909 | SH |  | SOLE |  | 4909 | 0 | 0 |
| WELLS FARGO  CO | Common Stock | 949746101 |  | 711554 | 8938 | SH |  | SOLE |  | 8938 | 0 | 0 |
| LIGAND PHARMACEUTICALS | Common Stock | 53220K504 |  | 706561 | 3539 | SH |  | SOLE |  | 3539 | 0 | 0 |
| SPYRE THERAPEUTICS INC | Common Stock | 00773J202 |  | 703033 | 13938 | SH |  | SOLE |  | 13938 | 0 | 0 |
| JOYY INC-ADR | ADR | 46591M109 |  | 700680 | 12000 | SH |  | SOLE |  | 12000 | 0 | 0 |
| UNITEDHEALTH GROUP INC | Common Stock | 91324P102 |  | 697852 | 2579 | SH |  | SOLE |  | 2579 | 0 | 0 |
| AMNEAL PHARMACEUTICALS INC | Common Stock | 03168L105 |  | 694017 | 55834 | SH |  | SOLE |  | 55834 | 0 | 0 |
| INDIVIOR PHARMACEUTICALS INC | Common Stock | 45579U109 |  | 676473 | 22194 | SH |  | SOLE |  | 22194 | 0 | 0 |
| GE VERNOVA INC | Common Stock | 36828A101 |  | 675066 | 773 | SH |  | SOLE |  | 773 | 0 | 0 |
| CRINETICS PHARMACEUTICALS IN | Common Stock | 22663K107 |  | 674862 | 18581 | SH |  | SOLE |  | 18581 | 0 | 0 |
| ACADIA PHARMACEUTICALS INC | Common Stock | 004225108 |  | 673499 | 30256 | SH |  | SOLE |  | 30256 | 0 | 0 |
| STRUCTURE THERAPEUTICS INC | ADR | 86366E106 |  | 666317 | 13824 | SH |  | SOLE |  | 13824 | 0 | 0 |
| SS CONSUMER DISC SELECT SECT | ETP | 81369Y407 |  | 657149 | 6030 | SH |  | SOLE |  | 6030 | 0 | 0 |
| INTL BUSINESS MACHINES CORP | Common Stock | 459200101 |  | 645242 | 2662 | SH |  | SOLE |  | 2662 | 0 | 0 |
| STMICROELECTRONICS NV-NY SHS | NY Reg Shrs | 861012102 |  | 621900 | 18000 | SH |  | SOLE |  | 18000 | 0 | 0 |
| VERIZON COMMUNICATIONS INC | Common Stock | 92343V104 |  | 602701 | 12006 | SH |  | SOLE |  | 12006 | 0 | 0 |
| ARM HOLDINGS PLC-ADR | ADR | 042068205 |  | 594228 | 3928 | SH |  | SOLE |  | 3928 | 0 | 0 |
| MEDTRONIC PLC | Common Stock | G5960L103 |  | 591882 | 6789 | SH |  | SOLE |  | 6789 | 0 | 0 |
| TRAVERE THERAPEUTICS INC | Common Stock | 89422G107 |  | 589001 | 19825 | SH |  | SOLE |  | 19825 | 0 | 0 |
| MORGAN STANLEY | Common Stock | 617446448 |  | 556411 | 3381 | SH |  | SOLE |  | 3381 | 0 | 0 |
| VNET GROUP INC-ADR | ADR | 90138A103 |  | 545350 | 65000 | SH |  | SOLE |  | 65000 | 0 | 0 |
| DISC MEDICINE INC | Common Stock | 254604101 |  | 535306 | 8372 | SH |  | SOLE |  | 8372 | 0 | 0 |
| TARSUS PHARMACEUTICALS INC | Common Stock | 87650L103 |  | 529773 | 7552 | SH |  | SOLE |  | 7552 | 0 | 0 |
| DYNE THERAPEUTICS INC | Common Stock | 26818M108 |  | 529740 | 29219 | SH |  | SOLE |  | 29219 | 0 | 0 |
| SUPERNUS PHARMACEUTICALS INC | Common Stock | 868459108 |  | 525946 | 10175 | SH |  | SOLE |  | 10175 | 0 | 0 |
| IDEAYA BIOSCIENCES INC | Common Stock | 45166A102 |  | 519226 | 15583 | SH |  | SOLE |  | 15583 | 0 | 0 |
| ARCUTIS BIOTHERAPEUTICS INC | Common Stock | 03969K108 |  | 518579 | 22011 | SH |  | SOLE |  | 22011 | 0 | 0 |
| TWIST BIOSCIENCE CORP | Common Stock | 90184D100 |  | 517018 | 10880 | SH |  | SOLE |  | 10880 | 0 | 0 |
| RAMBUS INC | Common Stock | 750917106 |  | 516180 | 6000 | SH |  | SOLE |  | 6000 | 0 | 0 |
| SAREPTA THERAPEUTICS INC | Common Stock | 803607100 |  | 513427 | 23595 | SH |  | SOLE |  | 23595 | 0 | 0 |
| EYEPOINT INC | Common Stock | 30233G209 |  | 511617 | 39691 | SH |  | SOLE |  | 39691 | 0 | 0 |
| VERA THERAPEUTICS INC | Common Stock | 92337R101 |  | 509432 | 12663 | SH |  | SOLE |  | 12663 | 0 | 0 |
| TANGO THERAPEUTICS INC | Common Stock | 87583X109 |  | 499988 | 23900 | SH |  | SOLE |  | 23900 | 0 | 0 |
| ALUMIS INC | Common Stock | 022307102 |  | 494265 | 22436 | SH |  | SOLE |  | 22436 | 0 | 0 |
| STOKE THERAPEUTICS INC | Common Stock | 86150R107 |  | 492828 | 15136 | SH |  | SOLE |  | 15136 | 0 | 0 |
| RUBRIK INC-A | Common Stock | 781154109 |  | 489700 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| COSTAR GROUP INC | Common Stock | 22160N109 |  | 476375 | 11809 | SH |  | SOLE |  | 11809 | 0 | 0 |
| NATERA INC | Common Stock | 632307104 |  | 465977 | 2330 | SH |  | SOLE |  | 2330 | 0 | 0 |
| VERACYTE INC | Common Stock | 92337F107 |  | 454193 | 14101 | SH |  | SOLE |  | 14101 | 0 | 0 |
| NIO INC - ADR | ADR | 62914V106 |  | 452250 | 75000 | SH |  | SOLE |  | 75000 | 0 | 0 |
| 10X GENOMICS INC-CLASS A | Common Stock | 88025U109 |  | 443325 | 20882 | SH |  | SOLE |  | 20882 | 0 | 0 |
| BEAM THERAPEUTICS INC | Common Stock | 07373V105 |  | 430727 | 18075 | SH |  | SOLE |  | 18075 | 0 | 0 |
| INTELLIA THERAPEUTICS INC | Common Stock | 45826J105 |  | 429008 | 33464 | SH |  | SOLE |  | 33464 | 0 | 0 |
| BIOCRYST PHARMACEUTICALS INC | Common Stock | 09058V103 |  | 423707 | 44507 | SH |  | SOLE |  | 44507 | 0 | 0 |
| GRAIL INC | Common Stock | 384747101 |  | 422122 | 8168 | SH |  | SOLE |  | 8168 | 0 | 0 |
| ORUKA THERAPEUTICS INC | Common Stock | 687604108 |  | 421389 | 8591 | SH |  | SOLE |  | 8591 | 0 | 0 |
| KODIAK SCIENCES INC | Common Stock | 50015M109 |  | 412992 | 10834 | SH |  | SOLE |  | 10834 | 0 | 0 |
| ENLIVEN THERAPEUTICS INC | Common Stock | 29337E102 |  | 412854 | 10532 | SH |  | SOLE |  | 10532 | 0 | 0 |
| AGILENT TECHNOLOGIES INC | Common Stock | 00846U101 |  | 411154 | 3600 | SH |  | SOLE |  | 3600 | 0 | 0 |
| WERIDE INC-ADR | ADR | 950915108 |  | 404500 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| ON SEMICONDUCTOR | Common Stock | 682189105 |  | 402480 | 6500 | SH |  | SOLE |  | 6500 | 0 | 0 |
| ADAPTIVE BIOTECHNOLOGIES | Common Stock | 00650F109 |  | 401479 | 28925 | SH |  | SOLE |  | 28925 | 0 | 0 |
| CORVUS PHARMACEUTICALS INC | Common Stock | 221015100 |  | 397278 | 27155 | SH |  | SOLE |  | 27155 | 0 | 0 |
| DAY ONE BIOPHARMACEUTICALS I | Common Stock | 23954D109 |  | 393017 | 18331 | SH |  | SOLE |  | 18331 | 0 | 0 |
| KINIKSA PHARMACEUTICALS INTE | Common Stock | G52694109 |  | 392182 | 8145 | SH |  | SOLE |  | 8145 | 0 | 0 |
| TREVI THERAPEUTICS INC | Common Stock | 89532M101 |  | 390767 | 32755 | SH |  | SOLE |  | 32755 | 0 | 0 |
| HESAI GROUP | ADR | 428050108 |  | 382400 | 20000 | SH |  | SOLE |  | 20000 | 0 | 0 |
| DEFINIUM THERAPEUTICS INC | Common Stock | 24477V105 |  | 381629 | 20192 | SH |  | SOLE |  | 20192 | 0 | 0 |
| ADMA BIOLOGICS INC | Common Stock | 000899104 |  | 380790 | 42263 | SH |  | SOLE |  | 42263 | 0 | 0 |
| MINERALYS THERAPEUTICS INC | Common Stock | 603170101 |  | 380452 | 14044 | SH |  | SOLE |  | 14044 | 0 | 0 |
| RAPPORT THERAPEUTICS INC | Common Stock | 75383L102 |  | 377295 | 12058 | SH |  | SOLE |  | 12058 | 0 | 0 |
| REPLIGEN CORP | Common Stock | 759916109 |  | 377024 | 3200 | SH |  | SOLE |  | 3200 | 0 | 0 |
| DESIGN THERAPEUTICS INC | Common Stock | 25056L103 |  | 373560 | 35109 | SH |  | SOLE |  | 35109 | 0 | 0 |
| ELEVANCE HEALTH INC | Common Stock | 036752103 |  | 365938 | 1250 | SH |  | SOLE |  | 1250 | 0 | 0 |
| SYNDAX PHARMACEUTICALS INC | Common Stock | 87164F105 |  | 365631 | 15652 | SH |  | SOLE |  | 15652 | 0 | 0 |
| TYRA BIOSCIENCES INC | Common Stock | 90240B106 |  | 362739 | 9471 | SH |  | SOLE |  | 9471 | 0 | 0 |
| ULTRAGENYX PHARMACEUTICAL IN | Common Stock | 90400D108 |  | 359251 | 17148 | SH |  | SOLE |  | 17148 | 0 | 0 |
| MAZE THERAPEUTICS INC | Common Stock | 578784100 |  | 358051 | 11995 | SH |  | SOLE |  | 11995 | 0 | 0 |
| AGIOS PHARMACEUTICALS INC | Common Stock | 00847X104 |  | 351764 | 10398 | SH |  | SOLE |  | 10398 | 0 | 0 |
| ZETA GLOBAL HOLDINGS CORP-A | Common Stock | 98956A105 |  | 350240 | 22000 | SH |  | SOLE |  | 22000 | 0 | 0 |
| AURINIA PHARMACEUTICALS INC | Common Stock | 05156V102 |  | 349708 | 23597 | SH |  | SOLE |  | 23597 | 0 | 0 |
| ANAPTYSBIO INC | Common Stock | 032724106 |  | 341855 | 6164 | SH |  | SOLE |  | 6164 | 0 | 0 |
| INSULET CORP | Common Stock | 45784P101 |  | 335744 | 1600 | SH |  | SOLE |  | 1600 | 0 | 0 |
| ZYMEWORKS INC | Common Stock | 98985Y108 |  | 332531 | 13280 | SH |  | SOLE |  | 13280 | 0 | 0 |
| OCULAR THERAPEUTIX INC | Common Stock | 67576A100 |  | 327205 | 38631 | SH |  | SOLE |  | 38631 | 0 | 0 |
| ATLASSIAN CORP-CL A | Common Stock | 049468101 |  | 325621 | 4771 | SH |  | SOLE |  | 4771 | 0 | 0 |
| IMMUNOCORE HOLDINGS PLC-ADR | ADR | 45258D105 |  | 325107 | 10783 | SH |  | SOLE |  | 10783 | 0 | 0 |
| PHARVARIS NV | Common Stock | N69605108 |  | 321118 | 11367 | SH |  | SOLE |  | 11367 | 0 | 0 |
| ANNEXON INC | Common Stock | 03589W102 |  | 319564 | 57683 | SH |  | SOLE |  | 57683 | 0 | 0 |
| SIONNA THERAPEUTICS INC | Common Stock | 829401108 |  | 317513 | 7920 | SH |  | SOLE |  | 7920 | 0 | 0 |
| RELAY THERAPEUTICS INC | Common Stock | 75943R102 |  | 315574 | 31716 | SH |  | SOLE |  | 31716 | 0 | 0 |
| QUEST DIAGNOSTICS INC | Common Stock | 74834L100 |  | 313568 | 1600 | SH |  | SOLE |  | 1600 | 0 | 0 |
| HILTON WORLDWIDE HOLDINGS IN | Common Stock | 43300A203 |  | 310466 | 1021 | SH |  | SOLE |  | 1021 | 0 | 0 |
| GENMAB A/S -SP ADR | ADR | 372303206 |  | 306506 | 11424 | SH |  | SOLE |  | 11424 | 0 | 0 |
| INNOVIVA INC | Common Stock | 45781M101 |  | 306279 | 13145 | SH |  | SOLE |  | 13145 | 0 | 0 |
| ANI PHARMACEUTICALS INC | Common Stock | 00182C103 |  | 305908 | 3978 | SH |  | SOLE |  | 3978 | 0 | 0 |
| NOVO-NORDISK A/S-SPONS ADR | ADR | 670100205 |  | 305093 | 8100 | SH |  | SOLE |  | 8100 | 0 | 0 |
| SNOWFLAKE INC | Common Stock | 833445109 |  | 301640 | 2000 | SH |  | SOLE |  | 2000 | 0 | 0 |
| ASTERA LABS INC | Common Stock | 04626A103 |  | 295920 | 2700 | SH |  | SOLE |  | 2700 | 0 | 0 |
| VERICEL CORP | Common Stock | 92346J108 |  | 289787 | 9008 | SH |  | SOLE |  | 9008 | 0 | 0 |
| NEKTAR THERAPEUTICS | Common Stock | 640268306 |  | 287800 | 4000 | SH |  | SOLE |  | 4000 | 0 | 0 |
| HARMONY BIOSCIENCES HOLDINGS | Common Stock | 413197104 |  | 287495 | 10264 | SH |  | SOLE |  | 10264 | 0 | 0 |
| SEPTERNA INC | Common Stock | 81734D104 |  | 287062 | 11946 | SH |  | SOLE |  | 11946 | 0 | 0 |
| RECURSION PHARMACEUTICALS-A | Common Stock | 75629V104 |  | 284356 | 92624 | SH |  | SOLE |  | 92624 | 0 | 0 |
| NURIX THERAPEUTICS INC | Common Stock | 67080M103 |  | 282875 | 18250 | SH |  | SOLE |  | 18250 | 0 | 0 |
| CREDO TECHNOLOGY GROUP HOLDI | Common Stock | G25457105 |  | 281610 | 3000 | SH |  | SOLE |  | 3000 | 0 | 0 |
| IQVIA HOLDINGS INC | Common Stock | 46266C105 |  | 272864 | 1600 | SH |  | SOLE |  | 1600 | 0 | 0 |
| LEGEND BIOTECH CORP-ADR | ADR | 52490G102 |  | 270952 | 14978 | SH |  | SOLE |  | 14978 | 0 | 0 |
| AMYLYX PHARMACEUTICALS INC | Common Stock | 03237H101 |  | 270883 | 19488 | SH |  | SOLE |  | 19488 | 0 | 0 |
| ATAIBECKLEY INC | Common Stock | 04650F101 |  | 266403 | 75255 | SH |  | SOLE |  | 75255 | 0 | 0 |
| ZENAS BIOPHARMA INC | Common Stock | 98937L105 |  | 264433 | 13526 | SH |  | SOLE |  | 13526 | 0 | 0 |
| ARDELYX INC | Common Stock | 039697107 |  | 260691 | 43521 | SH |  | SOLE |  | 43521 | 0 | 0 |
| CYTOMX THERAPEUTICS INC | Common Stock | 23284F105 |  | 258820 | 55068 | SH |  | SOLE |  | 55068 | 0 | 0 |
| IOVANCE BIOTHERAPEUTICS INC | Common Stock | 462260100 |  | 256602 | 73106 | SH |  | SOLE |  | 73106 | 0 | 0 |
| VIR BIOTECHNOLOGY INC | Common Stock | 92764N102 |  | 249894 | 27890 | SH |  | SOLE |  | 27890 | 0 | 0 |
| XERIS BIOPHARMA HOLDINGS INC | Common Stock | 98422E103 |  | 245021 | 42245 | SH |  | SOLE |  | 42245 | 0 | 0 |
| PRECIGEN INC | Common Stock | 74017N105 |  | 242993 | 62789 | SH |  | SOLE |  | 62789 | 0 | 0 |
| WAVE LIFE SCIENCES LTD | Common Stock | Y95308105 |  | 242201 | 33407 | SH |  | SOLE |  | 33407 | 0 | 0 |
| VICOR CORP | Common Stock | 925815102 |  | 241500 | 1500 | SH |  | SOLE |  | 1500 | 0 | 0 |
| MBX BIOSCIENCES INC | Common Stock | 55287L101 |  | 237845 | 7968 | SH |  | SOLE |  | 7968 | 0 | 0 |
| NOVAVAX INC | Common Stock | 670002401 |  | 235360 | 28914 | SH |  | SOLE |  | 28914 | 0 | 0 |
| HARROW INC | Common Stock | 415858109 |  | 231764 | 6573 | SH |  | SOLE |  | 6573 | 0 | 0 |
| DECKERS OUTDOOR CORP | Common Stock | 243537107 |  | 226504 | 2263 | SH |  | SOLE |  | 2263 | 0 | 0 |
| ORIC PHARMACEUTICALS INC | Common Stock | 68622P109 |  | 225640 | 17809 | SH |  | SOLE |  | 17809 | 0 | 0 |
| RESMED INC | Common Stock | 761152107 |  | 224480 | 1000 | SH |  | SOLE |  | 1000 | 0 | 0 |
| BICARA THERAPEUTICS INC | Common Stock | 055477103 |  | 223643 | 11244 | SH |  | SOLE |  | 11244 | 0 | 0 |
| MONTE ROSA THERAPEUTICS INC | Common Stock | 61225M102 |  | 222569 | 13530 | SH |  | SOLE |  | 13530 | 0 | 0 |
| NOVOCURE LTD | Common Stock | G6674U108 |  | 220115 | 20194 | SH |  | SOLE |  | 20194 | 0 | 0 |
| TAYSHA GENE THERAPIES INC | Common Stock | 877619106 |  | 217282 | 48609 | SH |  | SOLE |  | 48609 | 0 | 0 |
| OLEMA PHARMACEUTICALS INC | Common Stock | 68062P106 |  | 212095 | 14225 | SH |  | SOLE |  | 14225 | 0 | 0 |
| CHINA YUCHAI INTL LTD | Common Stock | G21082105 |  | 211750 | 5500 | SH |  | SOLE |  | 5500 | 0 | 0 |
| AUTOLIV INC | Common Stock | 052800109 |  | 210320 | 2000 | SH |  | SOLE |  | 2000 | 0 | 0 |
| PHIBRO ANIMAL HEALTH CORP-A | Common Stock | 71742Q106 |  | 202435 | 3660 | SH |  | SOLE |  | 3660 | 0 | 0 |
| ALVOTECH SA | Common Stock | L01800108 |  | 201039 | 58612 | SH |  | SOLE |  | 58612 | 0 | 0 |
| OMEROS CORP | Common Stock | 682143102 |  | 200450 | 18982 | SH |  | SOLE |  | 18982 | 0 | 0 |
| SAVARA INC | Common Stock | 805111101 |  | 197144 | 36107 | SH |  | SOLE |  | 36107 | 0 | 0 |
| TECTONIC THERAPEUTIC INC | Common Stock | 878972108 |  | 195722 | 6332 | SH |  | SOLE |  | 6332 | 0 | 0 |
| GH RESEARCH PLC | Common Stock | G3855L106 |  | 189908 | 13507 | SH |  | SOLE |  | 13507 | 0 | 0 |
| IRHYTHM HOLDINGS INC | Common Stock | 450056106 |  | 188832 | 1600 | SH |  | SOLE |  | 1600 | 0 | 0 |
| ABCELLERA BIOLOGICS INC | Common Stock | 00288U106 |  | 187755 | 53798 | SH |  | SOLE |  | 53798 | 0 | 0 |
| COLLEGIUM PHARMACEUTICAL INC | Common Stock | 19459J104 |  | 186349 | 5635 | SH |  | SOLE |  | 5635 | 0 | 0 |
| UNIQURE NV | Common Stock | N90064101 |  | 180733 | 11054 | SH |  | SOLE |  | 11054 | 0 | 0 |
| KALVISTA PHARMACEUTICALS INC | Common Stock | 483497103 |  | 180566 | 8970 | SH |  | SOLE |  | 8970 | 0 | 0 |
| CONTINEUM THERAPEUTICS INC-A | Common Stock | 21217B100 |  | 176349 | 13503 | SH |  | SOLE |  | 13503 | 0 | 0 |
| GRIFOLS SA-ADR | ADR | 398438408 |  | 173625 | 21649 | SH |  | SOLE |  | 21649 | 0 | 0 |
| INHIBRX BIOSCIENCES INC | Common Stock | 45720N103 |  | 173521 | 2581 | SH |  | SOLE |  | 2581 | 0 | 0 |
| ARRIVENT BIOPHARMA INC | Common Stock | 04272N102 |  | 169011 | 7326 | SH |  | SOLE |  | 7326 | 0 | 0 |
| GERON CORP | Common Stock | 374163103 |  | 168789 | 113281 | SH |  | SOLE |  | 113281 | 0 | 0 |
| KARYOPHARM THERAPEUTICS INC | Common Stock | 48576U205 |  | 167100 | 30000 | SH |  | SOLE |  | 30000 | 0 | 0 |
| PACIRA BIOSCIENCES INC | Common Stock | 695127100 |  | 162381 | 7185 | SH |  | SOLE |  | 7185 | 0 | 0 |
| ARVINAS INC | Common Stock | 04335A105 |  | 158470 | 14950 | SH |  | SOLE |  | 14950 | 0 | 0 |
| AMPHASTAR PHARMACEUTICALS IN | Common Stock | 03209R103 |  | 157719 | 8051 | SH |  | SOLE |  | 8051 | 0 | 0 |
| XENCOR INC | Common Stock | 98401F105 |  | 156961 | 13015 | SH |  | SOLE |  | 13015 | 0 | 0 |
| FORTREA HOLDINGS INC | Common Stock | 34965K107 |  | 156297 | 16592 | SH |  | SOLE |  | 16592 | 0 | 0 |
| PHATHOM PHARMACEUTICALS INC | Common Stock | 71722W107 |  | 155351 | 13983 | SH |  | SOLE |  | 13983 | 0 | 0 |
| ARBUTUS BIOPHARMA CORP | Common Stock | 03879J100 |  | 153581 | 34129 | SH |  | SOLE |  | 34129 | 0 | 0 |
| JANUX THERAPEUTICS INC | Common Stock | 47103J105 |  | 150051 | 10795 | SH |  | SOLE |  | 10795 | 0 | 0 |
| UROGEN PHARMA LTD | Common Stock | M96088105 |  | 149360 | 8307 | SH |  | SOLE |  | 8307 | 0 | 0 |
| CULLINAN THERAPEUTICS INC | Common Stock | 230031106 |  | 148978 | 10484 | SH |  | SOLE |  | 10484 | 0 | 0 |
| THERAVANCE BIOPHARMA INC | Common Stock | G8807B106 |  | 145940 | 8992 | SH |  | SOLE |  | 8992 | 0 | 0 |
| MESOBLAST LTD- SPON ADR | ADR | 590717401 |  | 142880 | 9290 | SH |  | SOLE |  | 9290 | 0 | 0 |
| ARS PHARMACEUTICALS INC | Common Stock | 82835W108 |  | 140854 | 17541 | SH |  | SOLE |  | 17541 | 0 | 0 |
| DIAGEO PLC-SPONSORED ADR | ADR | 25243Q205 |  | 140264 | 1884 | SH |  | SOLE |  | 1884 | 0 | 0 |
| GLOBUS MEDICAL INC - A | Common Stock | 379577208 |  | 137856 | 1600 | SH |  | SOLE |  | 1600 | 0 | 0 |
| SANA BIOTECHNOLOGY INC | Common Stock | 799566104 |  | 136135 | 47269 | SH |  | SOLE |  | 47269 | 0 | 0 |
| BIOAGE LABS INC | Common Stock | 09077V100 |  | 134795 | 7707 | SH |  | SOLE |  | 7707 | 0 | 0 |
| MANNKIND CORP | Common Stock | 56400P706 |  | 133954 | 54675 | SH |  | SOLE |  | 54675 | 0 | 0 |
| VOR BIOPHARMA INC | Common Stock | 929033207 |  | 131445 | 7368 | SH |  | SOLE |  | 7368 | 0 | 0 |
| CASTLE BIOSCIENCES INC | Common Stock | 14843C105 |  | 129526 | 5276 | SH |  | SOLE |  | 5276 | 0 | 0 |
| ZURA BIO LTD | Common Stock | G9TY5A101 |  | 128520 | 21600 | SH |  | SOLE |  | 21600 | 0 | 0 |
| ABSCI CORP | Common Stock | 00091E109 |  | 128055 | 42685 | SH |  | SOLE |  | 42685 | 0 | 0 |
| KURA ONCOLOGY INC | Common Stock | 50127T109 |  | 125543 | 15442 | SH |  | SOLE |  | 15442 | 0 | 0 |
| PROCEPT BIOROBOTICS CORP | Common Stock | 74276L105 |  | 125050 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| PALVELLA THERAPEUTICS INC | Common Stock | 697947109 |  | 124650 | 1000 | SH |  | SOLE |  | 1000 | 0 | 0 |
| MEIRAGTX HOLDINGS PLC | Common Stock | G59665102 |  | 123699 | 14284 | SH |  | SOLE |  | 14284 | 0 | 0 |
| PERSONALIS INC | Common Stock | 71535D106 |  | 118278 | 18568 | SH |  | SOLE |  | 18568 | 0 | 0 |
| ETON PHARMACEUTICALS INC | Common Stock | 29772L108 |  | 117452 | 4759 | SH |  | SOLE |  | 4759 | 0 | 0 |
| ESPERION THERAPEUTICS INC | Common Stock | 29664W105 |  | 116242 | 42424 | SH |  | SOLE |  | 42424 | 0 | 0 |
| EVOMMUNE INC | Common Stock | 30054Y107 |  | 114950 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| ZAI LAB LTD-ADR | ADR | 98887Q104 |  | 114459 | 6085 | SH |  | SOLE |  | 6085 | 0 | 0 |
| REPLIMUNE GROUP INC | Common Stock | 76029N106 |  | 112095 | 14653 | SH |  | SOLE |  | 14653 | 0 | 0 |
| PRIME MEDICINE INC | Common Stock | 74168J101 |  | 111475 | 32033 | SH |  | SOLE |  | 32033 | 0 | 0 |
| UXIN LTD - ADR | ADR | 91818X306 |  | 107450 | 35000 | SH |  | SOLE |  | 35000 | 0 | 0 |
| DBV TECHNOLOGIES SA-SPON ADR | ADR | 23306J309 |  | 104450 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| IRONWOOD PHARMACEUTICALS INC | Common Stock | 46333X108 |  | 101565 | 28936 | SH |  | SOLE |  | 28936 | 0 | 0 |
| SOLID BIOSCIENCES INC | Common Stock | 83422E204 |  | 99547 | 13826 | SH |  | SOLE |  | 13826 | 0 | 0 |
| TRANSMEDICS GROUP INC | Common Stock | 89377M109 |  | 99410 | 1000 | SH |  | SOLE |  | 1000 | 0 | 0 |
| ALLOGENE THERAPEUTICS INC | Common Stock | 019770106 |  | 97307 | 39880 | SH |  | SOLE |  | 39880 | 0 | 0 |
| TANDEM DIABETES CARE INC | Common Stock | 875372203 |  | 95850 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| CORMEDIX INC | Common Stock | 21900C308 |  | 94938 | 13982 | SH |  | SOLE |  | 13982 | 0 | 0 |
| ZEVRA THERAPEUTICS INC | Common Stock | 488445206 |  | 93107 | 9990 | SH |  | SOLE |  | 9990 | 0 | 0 |
| PROTHENA CORP PLC | Common Stock | G72800108 |  | 92855 | 9553 | SH |  | SOLE |  | 9553 | 0 | 0 |
| COMPASS PATHWAYS PLC | ADR | 20451W101 |  | 92545 | 16735 | SH |  | SOLE |  | 16735 | 0 | 0 |
| BIOHAVEN LTD | Common Stock | G1110E107 |  | 91368 | 10800 | SH |  | SOLE |  | 10800 | 0 | 0 |
| FULCRUM THERAPEUTICS INC | Common Stock | 359616109 |  | 90652 | 11819 | SH |  | SOLE |  | 11819 | 0 | 0 |
| INVIVYD INC | Common Stock | 00534A102 |  | 89931 | 69178 | SH |  | SOLE |  | 69178 | 0 | 0 |
| AQUESTIVE THERAPEUTICS INC | Common Stock | 03843E104 |  | 89848 | 21650 | SH |  | SOLE |  | 21650 | 0 | 0 |
| LI AUTO INC - ADR | ADR | 50202M102 |  | 89150 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| INVENTIVA SA - ADR | ADR | 46124U107 |  | 88800 | 16000 | SH |  | SOLE |  | 16000 | 0 | 0 |
| KYVERNA THERAPEUTICS INC | Common Stock | 501976104 |  | 87491 | 10138 | SH |  | SOLE |  | 10138 | 0 | 0 |
| KAMADA LTD | Common Stock | M6240T109 |  | 87222 | 10236 | SH |  | SOLE |  | 10236 | 0 | 0 |
| RIGEL PHARMACEUTICALS INC | Common Stock | 766559702 |  | 87096 | 3221 | SH |  | SOLE |  | 3221 | 0 | 0 |
| LARIMAR THERAPEUTICS INC | Common Stock | 517125100 |  | 86715 | 19270 | SH |  | SOLE |  | 19270 | 0 | 0 |
| UPSTREAM BIO INC | Common Stock | 91678A107 |  | 86310 | 9590 | SH |  | SOLE |  | 9590 | 0 | 0 |
| ENTRADA THERAPEUTICS INC | Common Stock | 29384C108 |  | 85740 | 6794 | SH |  | SOLE |  | 6794 | 0 | 0 |
| 4D MOLECULAR THERAPEUTICS IN | Common Stock | 35104E100 |  | 84274 | 9052 | SH |  | SOLE |  | 9052 | 0 | 0 |
| AXOGEN INC | Common Stock | 05463X106 |  | 82825 | 2500 | SH |  | SOLE |  | 2500 | 0 | 0 |
| ACLARIS THERAPEUTICS INC | Common Stock | 00461U105 |  | 80254 | 21401 | SH |  | SOLE |  | 21401 | 0 | 0 |
| GALAPAGOS NV-SPON ADR | ADR | 36315X101 |  | 78930 | 2631 | SH |  | SOLE |  | 2631 | 0 | 0 |
| SS SPDR S BIOTECH ETF | ETP | 78464A870 |  | 77660 | 608 | SH |  | SOLE |  | 608 | 0 | 0 |
| LYELL IMMUNOPHARMA INC | Common Stock | 55083R203 |  | 75626 | 3770 | SH |  | SOLE |  | 3770 | 0 | 0 |
| AURA BIOSCIENCES INC | Common Stock | 05153U107 |  | 75390 | 11269 | SH |  | SOLE |  | 11269 | 0 | 0 |
| REGENXBIO INC | Common Stock | 75901B107 |  | 75278 | 8983 | SH |  | SOLE |  | 8983 | 0 | 0 |
| ATEA PHARMACEUTICALS INC | Common Stock | 04683R106 |  | 74588 | 13864 | SH |  | SOLE |  | 13864 | 0 | 0 |
| LEXEO THERAPEUTICS INC | Common Stock | 52886X107 |  | 74344 | 12952 | SH |  | SOLE |  | 12952 | 0 | 0 |
| MARAVAI LIFESCIENCES HLDGS-A | Common Stock | 56600D107 |  | 73515 | 25977 | SH |  | SOLE |  | 25977 | 0 | 0 |
| SURROZEN INC | Common Stock | 86889P208 |  | 72825 | 2500 | SH |  | SOLE |  | 2500 | 0 | 0 |
| VANDA PHARMACEUTICALS INC | Common Stock | 921659108 |  | 72479 | 10489 | SH |  | SOLE |  | 10489 | 0 | 0 |
| EUPRAXIA PHARMACEUTICALS INC | Common Stock | 29842P105 |  | 72400 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| ABRDN PHYSICAL SILVER SHARES | ETP | 003264108 |  | 71610 | 1000 | SH |  | SOLE |  | 1000 | 0 | 0 |
| PACIFIC BIOSCIENCES OF CALIF | Common Stock | 69404D108 |  | 70741 | 53592 | SH |  | SOLE |  | 53592 | 0 | 0 |
| CAMP4 THERAPEUTICS CORP | Common Stock | 13463J101 |  | 70560 | 16000 | SH |  | SOLE |  | 16000 | 0 | 0 |
| ALPHATEC HOLDINGS INC | Common Stock | 02081G201 |  | 69632 | 6400 | SH |  | SOLE |  | 6400 | 0 | 0 |
| ROCKET PHARMACEUTICALS INC | Common Stock | 77313F106 |  | 68972 | 19266 | SH |  | SOLE |  | 19266 | 0 | 0 |
| ALTIMMUNE INC | Common Stock | 02155H200 |  | 68447 | 22223 | SH |  | SOLE |  | 22223 | 0 | 0 |
| ISHARES SILVER TRUST | ETP | 46428Q109 |  | 68140 | 1000 | SH |  | SOLE |  | 1000 | 0 | 0 |
| SIGA TECHNOLOGIES INC | Common Stock | 826917106 |  | 67988 | 12708 | SH |  | SOLE |  | 12708 | 0 | 0 |
| ENANTA PHARMACEUTICALS INC | Common Stock | 29251M106 |  | 65045 | 5150 | SH |  | SOLE |  | 5150 | 0 | 0 |
| CANDEL THERAPEUTICS INC | Common Stock | 137404109 |  | 63690 | 12998 | SH |  | SOLE |  | 12998 | 0 | 0 |
| IMMUNEERING CORP - CLASS A | Common Stock | 45254E107 |  | 60384 | 11458 | SH |  | SOLE |  | 11458 | 0 | 0 |
| KEROS THERAPEUTICS INC | Common Stock | 492327101 |  | 59682 | 5406 | SH |  | SOLE |  | 5406 | 0 | 0 |
| NEUMORA THERAPEUTICS INC | Common Stock | 640979100 |  | 57819 | 29651 | SH |  | SOLE |  | 29651 | 0 | 0 |
| PUMA BIOTECHNOLOGY INC | Common Stock | 74587V107 |  | 57689 | 9028 | SH |  | SOLE |  | 9028 | 0 | 0 |
| NEUROGENE INC | Common Stock | 64135M105 |  | 55420 | 2749 | SH |  | SOLE |  | 2749 | 0 | 0 |
| SHOULDER INNOVATIONS INC | Common Stock | 82537J108 |  | 52308 | 3600 | SH |  | SOLE |  | 3600 | 0 | 0 |
| LENZ THERAPEUTICS INC | Common Stock | 52635N103 |  | 50810 | 5553 | SH |  | SOLE |  | 5553 | 0 | 0 |
| ANAVEX LIFE SCIENCES CORP | Common Stock | 032797300 |  | 50486 | 16445 | SH |  | SOLE |  | 16445 | 0 | 0 |
| KESTRA MEDICAL TECHNOLOGIES | Common Stock | G52441105 |  | 49825 | 2500 | SH |  | SOLE |  | 2500 | 0 | 0 |
| FOGHORN THERAPEUTICS INC | Common Stock | 344174107 |  | 49693 | 10396 | SH |  | SOLE |  | 10396 | 0 | 0 |
| AUTOLUS THERAPEUTICS PLC | ADR | 05280R100 |  | 49124 | 35597 | SH |  | SOLE |  | 35597 | 0 | 0 |
| AC IMMUNE SA | Common Stock | H00263105 |  | 49093 | 17852 | SH |  | SOLE |  | 17852 | 0 | 0 |
| NOVABRIDGE BIOSCIENCES | ADR | 44975P103 |  | 49001 | 19919 | SH |  | SOLE |  | 19919 | 0 | 0 |
| EVOLUS INC | Common Stock | 30052C107 |  | 47277 | 11503 | SH |  | SOLE |  | 11503 | 0 | 0 |
| CABALETTA BIO INC | Common Stock | 12674W109 |  | 45953 | 17083 | SH |  | SOLE |  | 17083 | 0 | 0 |
| C4 THERAPEUTICS INC | Common Stock | 12529R107 |  | 45541 | 17316 | SH |  | SOLE |  | 17316 | 0 | 0 |
| COHERUS ONCOLOGY INC | Common Stock | 19249H103 |  | 44827 | 26525 | SH |  | SOLE |  | 26525 | 0 | 0 |
| SILENCE THERAPEUTICS PLC-ADR | ADR | 82686Q101 |  | 43925 | 8335 | SH |  | SOLE |  | 8335 | 0 | 0 |
| OPTION CARE HEALTH INC | Common Stock | 68404L201 |  | 43072 | 1600 | SH |  | SOLE |  | 1600 | 0 | 0 |
| EDITAS MEDICINE INC | Common Stock | 28106W103 |  | 42788 | 17323 | SH |  | SOLE |  | 17323 | 0 | 0 |
| ORCHESTRA BIOMED HOLDINGS IN | Common Stock | 68572M106 |  | 42585 | 10020 | SH |  | SOLE |  | 10020 | 0 | 0 |
| DENTSPLY SIRONA INC | Common Stock | 24906P109 |  | 41760 | 3600 | SH |  | SOLE |  | 3600 | 0 | 0 |
| VOYAGER THERAPEUTICS INC | Common Stock | 92915B106 |  | 40368 | 10458 | SH |  | SOLE |  | 10458 | 0 | 0 |
| OMNIAB INC | Common Stock | 68218J103 |  | 40107 | 25546 | SH |  | SOLE |  | 25546 | 0 | 0 |
| ARCTURUS THERAPEUTICS HOLDIN | Common Stock | 03969T109 |  | 38924 | 5042 | SH |  | SOLE |  | 5042 | 0 | 0 |
| BICYCLE THERAPEUTICS PLC-ADR | ADR | 088786108 |  | 38150 | 8222 | SH |  | SOLE |  | 8222 | 0 | 0 |
| AVITA MEDICAL INC | Common Stock | 05380C102 |  | 37000 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| BRIGHT MINDS BIOSCIENCES INC | Common Stock | 10919W405 |  | 36485 | 500 | SH |  | SOLE |  | 500 | 0 | 0 |
| SATELLOS BIOSCIENCE INC | Common Stock | 80401L803 |  | 36032 | 6400 | SH |  | SOLE |  | 6400 | 0 | 0 |
| BROOKDALE SENIOR LIVING INC | Common Stock | 112463104 |  | 34200 | 2500 | SH |  | SOLE |  | 2500 | 0 | 0 |
| DIAMEDICA THERAPEUTICS INC | Common Stock | 25253X207 |  | 33850 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| PROQR THERAPEUTICS NV | Common Stock | N71542109 |  | 32400 | 20000 | SH |  | SOLE |  | 20000 | 0 | 0 |
| CARIBOU BIOSCIENCES INC | Common Stock | 142038108 |  | 31515 | 16587 | SH |  | SOLE |  | 16587 | 0 | 0 |
| VALNEVA SE - ADR | ADR | 92025Y103 |  | 31250 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| CYBIN INC | Common Stock | 23256X407 |  | 30720 | 6400 | SH |  | SOLE |  | 6400 | 0 | 0 |
| AMN HEALTHCARE SERVICES INC | Common Stock | 001744101 |  | 29344 | 1600 | SH |  | SOLE |  | 1600 | 0 | 0 |
| SAGIMET BIOSCIENCES INC-A | Common Stock | 786700104 |  | 28743 | 5501 | SH |  | SOLE |  | 5501 | 0 | 0 |
| JYONG BIOTECH LTD | Common Stock | G83116106 |  | 28322 | 13173 | SH |  | SOLE |  | 13173 | 0 | 0 |
| CANADIAN SOLAR INC | Common Stock | 136635109 |  | 27700 | 2000 | SH |  | SOLE |  | 2000 | 0 | 0 |
| ALPHA TEKNOVA INC | Common Stock | 02080L102 |  | 27452 | 9499 | SH |  | SOLE |  | 9499 | 0 | 0 |
| QUANTUM-SI INC | Common Stock | 74765K105 |  | 26859 | 34702 | SH |  | SOLE |  | 34702 | 0 | 0 |
| TENAYA THERAPEUTICS INC | Common Stock | 87990A106 |  | 26634 | 38466 | SH |  | SOLE |  | 38466 | 0 | 0 |
| CODEXIS INC | Common Stock | 192005106 |  | 26127 | 16029 | SH |  | SOLE |  | 16029 | 0 | 0 |
| LIFECORE BIOMEDICAL INC | Common Stock | 514766104 |  | 24734 | 6649 | SH |  | SOLE |  | 6649 | 0 | 0 |
| PEPGEN INC | Common Stock | 713317105 |  | 21594 | 12200 | SH |  | SOLE |  | 12200 | 0 | 0 |
| BLACK DIAMOND THERAPEUTICS I | Common Stock | 09203E105 |  | 21536 | 10111 | SH |  | SOLE |  | 10111 | 0 | 0 |
| HUMACYTE INC | Common Stock | 44486Q103 |  | 20779 | 34249 | SH |  | SOLE |  | 34249 | 0 | 0 |
| NIKE INC -CL B | Common Stock | 654106103 |  | 18616 | 350 | SH |  | SOLE |  | 350 | 0 | 0 |
| PYXIS ONCOLOGY INC | Common Stock | 747324101 |  | 16132 | 11049 | SH |  | SOLE |  | 11049 | 0 | 0 |
| CROSS COUNTRY HEALTHCARE INC | Common Stock | 227483104 |  | 15040 | 1600 | SH |  | SOLE |  | 1600 | 0 | 0 |
| AARDVARK THERAPEUTICS INC | Common Stock | 002942100 |  | 14567 | 3864 | SH |  | SOLE |  | 3864 | 0 | 0 |
| GOSSAMER BIO INC | Common Stock | 38341P102 |  | 13493 | 41074 | SH |  | SOLE |  | 41074 | 0 | 0 |
| RANI THERAPEUTICS HOLDINGS-A | Common Stock | 753018100 |  | 12720 | 17311 | SH |  | SOLE |  | 17311 | 0 | 0 |
| TENCENT MUSIC ENTERTAINM-ADR | ADR | 88034P109 |  | 4640 | 500 | SH |  | SOLE |  | 500 | 0 | 0 |
| HERSHEY CO/THE | Common Stock | 427866108 |  | 2079 | 10 | SH |  | SOLE |  | 10 | 0 | 0 |
| CHIPOTLE MEXICAN GRILL INC | Common Stock | 169656105 |  | 1953 | 61 | SH |  | SOLE |  | 61 | 0 | 0 |

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