# EDGAR Filing Document

**Accession Number:** 0001840748
**File Stem:** 0001104659-25-107725
**Filing Date:** 2025-11
**Character Count:** 141903
**Document Hash:** 703679c782157f4c4a8fca4e76ea9c78
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-25-107725.hdr.sgml**: 20251106

**ACCESSION NUMBER**: 0001104659-25-107725

**CONFORMED SUBMISSION TYPE**: 10-Q

**PUBLIC DOCUMENT COUNT**: 55

**CONFORMED PERIOD OF REPORT**: 20250930

**FILED AS OF DATE**: 20251106

**DATE AS OF CHANGE**: 20251106

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** LAVA Therapeutics NV
- **CENTRAL INDEX KEY:** 0001840748
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** P7
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 10-Q
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-40241
- **FILM NUMBER:** 251458260

**BUSINESS ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** YALELAAN 62
- **CITY:** UTRECHT
- **PROVINCE COUNTRY:** P7
- **BUSINESS PHONE:** 31 6 3000 3035

**MAIL ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** YALELAAN 62
- **CITY:** UTRECHT
- **PROVINCE COUNTRY:** P7

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** LAVA Therapeutics BV
- **DATE OF NAME CHANGE:** 20210115

?xml version='1.0' encoding='ASCII'? LAVA Therapeutics NV_September 30, 2025

[**Table of Contents**](#TOC)

------

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**WASHINGTON, D.C. 20549**

**FORM 10-Q**

**(Mark One)**

**☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934**

For the quarterly period ended September 30, 2025

**OR**

**☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934**

For the Transition period from to

Commission file number: **001-40241**

**LAVA Therapeutics N.V.**

(Exact Name of Registrant as Specified in Its Charter)

The Netherlands(State or Other Jurisdiction ofIncorporation or Organization) 84-2745484(I.R.S. EmployerIdentification No.) <br> Yalelaan 62Utrecht, The Netherlands(Address of Principal Executive Offices) 3584 CM(Zip Code)

**+31 85 016 3100**

(Registrant's telephone number, including area code)

Securities registered pursuant to Section 12(b) of the Act:

---

| | | |
|:---|:---|:---|
| Title of each class | Trading Symbol(s) | Name of each exchange on which registered |
| Common shares, par value €0.12 per share | LVTX | The Nasdaq Stock Market LLC<br>(NASDAQ Global Select Market) |

---

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.

Yes ☒ No ☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒ No ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b 2 of the Exchange Act.

Large accelerated filer ☐ Accelerated filer ☐ <br> Non-accelerated filer ☒ Smaller reporting company ☒ <br> Emerging growth company ☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒

The number of the registrant's Common Shares outstanding as of November 3, 2025 was 26,305,295.

------

[**Table of Contents**](#TOC)

**Table of Contents**

---

| | | |
|:---|:---|:---|
|  |  | Page |
|  | [Special Note Regarding Forward-Looking Statements](#SpecialNoteRegardingForwardLookingStatem) | 2 |
| [**PART I.**](#PARTIFINANCIALINFORMATION_380530) | [**FINANCIAL INFORMATION**](#PARTIFINANCIALINFORMATION_380530) | 4 |
| [Item 1.](#Item1FinancialStatements_151745) | [Financial Statements](#Item1FinancialStatements_151745) | 4 |
|  | [Condensed Consolidated Balance Sheets (Unaudited)](#ConsolidatedBalanceSheets_760189) | 4 |
|  | [Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited)](#ConsolidatedStatementsofOperationsandCom) | 5 |
|  | [Condensed Consolidated Statements of Stockholders' Equity (Unaudited)](#ConsolidatedStatementsofShareholdersEqui) | 6 |
|  | [Condensed Consolidated Statements of Cash Flows (Unaudited)](#statementsofcashflows_729528) | 7 |
|  | [Notes to the Condensed Consolidated Financial Statements (Unaudited)](#NotestotheCondensedConsolidatedFinancial) | 8 |
| [Item 2.](#Item2ManagementsDiscussionandAnalysisofF) | [Management's Discussion and Analysis of Financial Condition and Results of Operations](#Item2ManagementsDiscussionandAnalysisofF) | 18 |
| [Item 3.](#Item3QuantitativeandQualitativeDisclosur) | [Quantitative and Qualitative Disclosures About Market Risk](#Item3QuantitativeandQualitativeDisclosur) | 29 |
| [Item 4.](#Item4ControlsandProcedures_261328) | [Controls and Procedures](#Item4ControlsandProcedures_261328) | 30 |
| [**PART II.**](#PARTIIOTHERINFORMATION_301433) | [**OTHER INFORMATION**](#PARTIIOTHERINFORMATION_301433) | 31 |
| [Item 1.](#Item1LegalProceedings_11084) | [Legal Proceedings](#Item1LegalProceedings_11084) | 31 |
| [Item 1A.](#Item1ARiskFactors_586677) | [Risk Factors](#Item1ARiskFactors_586677) | 31 |
| [Item 2.](#Item2UnregisteredSalesofEquitySecurities) | [Unregistered Sales of Equity Securities and Use of Proceeds](#Item2UnregisteredSalesofEquitySecurities) | 35 |
| [Item 3.](#Item3DefaultsUponSeniorSecurities_516409) | [Defaults Upon Senior Securities](#Item3DefaultsUponSeniorSecurities_516409) | 35 |
| [Item 4.](#_Item_4._Mine) | [Mine Safety Disclosures](#Item4MineSafetyDisclosures) | 35 |
| [Item 5.](#Item5OtherInformation_339131) | [Other Information](#Item5OtherInformation_339131) | 35 |
| [Item 6.](#Item6Exhibits_863135) | [Exhibits](#Item6Exhibits_863135) | 36 |
| [Signatures](#SIGNATURES_74361) | [Signatures](#SIGNATURES_74361) | 38 |

---

[**Table of Contents**](#TOC)

#### Special Note Regarding Forward-Looking Statements
This Quarterly Report on Form 10-Q (Quarterly Report) contains statements that constitute forward-looking statements. Many of the forward-looking statements contained in this Quarterly Report can be identified by the use of forward-looking words such as "anticipate," "believe," "could," "expect," "should," "plan," "intend," "estimate," "potential," "may," "will," and "would," among others. Forward-looking statements are based on our management's beliefs and assumptions and on information currently available to our management. Forward-looking statements appear in a number of places in this Quarterly Report and include, but are not limited to, statements regarding our intent, belief or current expectations, such as statements about:

&nbsp;&nbsp;&nbsp;&nbsp;● our assessment of strategic alternatives;

&nbsp;&nbsp;&nbsp;&nbsp;● our ability to execute, while preserving our cash balance to the extent practicable, including proposed transactions contemplated by the Share Purchase Agreement, dated as of August 3, 2025 (the "Purchase Agreement"), between us and XOMA Royalty Corporation, a Delaware corporation ("XOMA"), as amended to date, including our expectations regarding the ability of the parties to complete the transactions contemplated by the Purchase Agreement, the ability of the parties to satisfy the conditions to the consummation of the tender offer contemplated by the Purchase Agreement (the "Offer"), including our ability to achieve the closing net cash amount, and the other conditions set forth in the Purchase Agreement, the possibility of any termination of the Purchase Agreement, our ability to retain key personnel, the expected timetable for completing the transactions contemplated by the Purchase Agreement, including any potential extensions of the Offer period, our and XOMA's beliefs and expectations and statements about the benefits sought to be achieved by XOMA's proposed acquisition of us, the potential effects of the acquisition on both us and XOMA and whether or not the conditions for payment in respect of contingent value rights (the "CVRs") pursuant to the Contingent Value Rights Agreement that we expect to enter into with a rights agent and a representative, agent and attorney-in-fact of the holders of the CVRs at or prior to the completion of the Offer will be met;

&nbsp;&nbsp;&nbsp;&nbsp;● the timing and outcome of our extraordinary general meeting of shareholders ("EGM") related to the transactions contemplated by the Purchase Agreement, including our ability to achieve quorum and the requisite votes at the EGM;

&nbsp;&nbsp;&nbsp;&nbsp;● the risk of unanticipated costs, liabilities or delays relating to the Purchase Agreement and related transactions, including the outcome of any legal proceedings or shareholder litigation;

&nbsp;&nbsp;&nbsp;&nbsp;● our ability to maintain our partnered programs including JNJ-89853413, targeting CD33 and hematologic cancers (NCT06618001), partnered with Johnson & Johnson, and PF-08046052, targeting EGFR-positive tumors (NCT05983133), partnered with Pfizer, Inc.;

&nbsp;&nbsp;&nbsp;&nbsp;● anticipated costs and efforts associated with the discontinuation of clinical programs including the LAVA-1207 program and the LAVA-1266 program;

&nbsp;&nbsp;&nbsp;&nbsp;● anticipated cost savings in connection with the discontinuation of the LAVA-1207 program and the LAVA-1266 program;

&nbsp;&nbsp;&nbsp;&nbsp;● our intellectual property position and the duration of our patent rights;

&nbsp;&nbsp;&nbsp;&nbsp;● our ability to dispose of our intellectual property, assets relating to the LAVA-1266 program, and other pre-clinical assets;

&nbsp;&nbsp;&nbsp;&nbsp;● our ability to control and correctly estimate our operating expenses and our expenses associated with the Purchase Agreement and transactions related thereto;

&nbsp;&nbsp;&nbsp;&nbsp;● our ability to engage and retain the employees required to operate our business and conclude or wind-up our clinical and pre-clinical work;

[**Table of Contents**](#TOC)

&nbsp;&nbsp;&nbsp;&nbsp;● compensation or severance expected to be paid to employees;

&nbsp;&nbsp;&nbsp;&nbsp;● our expectations regarding market risk, including inflation, interest rate changes and foreign currency fluctuations; and

&nbsp;&nbsp;&nbsp;&nbsp;● our estimates regarding our financial condition, expenses and capital requirements.

You should not rely on forward-looking statements as predictions of future events. We have based the forward-looking statements contained in this Quarterly Report primarily on our current expectations and projections about future events and trends that we believe may affect our business, financial condition, and results of operations. The outcome of the events described in these forward-looking statements is subject to risks and uncertainties, including the factors described in "Part I, Item 1A. Risk Factors" of our Annual Report on Form 10-K, or the Annual Report, filed with the Securities and Exchange Commission, or the SEC, on March 28, 2025, "Part II, Item 1A. Risk Factors" of our Quarterly Reports on Form 10-Q filed with the SEC on May 14, 2025 and August 13, 2025, and "Part II, Item 1A. Risk Factors" and elsewhere in this Quarterly Report. Moreover, we operate in a very competitive and rapidly changing environment. New risks and uncertainties emerge from time to time, and it is not possible for us to predict all risks and uncertainties that could have an impact on the forward-looking statements contained in this Quarterly Report. The results, events, and circumstances reflected in the forward-looking statements may not be achieved or occur, and actual results, events, or circumstances could differ materially from those described in the forward-looking statements.

In addition, statements that "we believe" and similar statements reflect our beliefs and opinions on the relevant subject. These statements are based on information available to us as of the date of this Quarterly Report. While we believe that such information provides a reasonable basis for these statements, that information may be limited or incomplete. Our statements should not be read to indicate that we have conducted an exhaustive inquiry into, or review of, all relevant information. These statements are inherently uncertain, and investors are cautioned not to unduly rely on these statements.

The forward-looking statements contained in this Quarterly Report relate only to events as of the date on which the statements are made. We undertake no obligation to update any forward-looking statements made in this Quarterly Report or to reflect new information or the occurrence of unanticipated events, except as required by law. We may not actually achieve the plans, intentions or expectations disclosed in or expressed by, and you should not place undue reliance on, our forward-looking statements. Our forward-looking statements do not reflect the potential impact of any future acquisitions, mergers, dispositions, joint ventures, or investments.

Unless the context otherwise requires, all references in this Quarterly Report to "we," "us," "our," "our Company," and "LAVA" refer to LAVA Therapeutics N.V. and its subsidiaries.

[**Table of Contents**](#TOC)

**PART I. FINANCIAL INFORMATION**

**Item 1. Financial Statements**

**LAVA Therapeutics N.V.**

**Condensed Consolidated Balance Sheets (Unaudited)**

**(In thousands, except par value and share data)**

---

| | | |
|:---|:---|:---|
|  | **September 30,** | **December 31,** |
|  | **2025** | **2024** |
| ***Assets*** |  |  |
| Current assets: |  |  |
| &nbsp;&nbsp;Cash and cash equivalents | $49664 | $35015 |
| &nbsp;&nbsp;Short-term investments |  | 41561 |
| &nbsp;&nbsp;Prepaid expenses | 141 | 1072 |
| &nbsp;&nbsp;Other current assets | 2100 | 1649 |
| Total current assets | **51905** | **79297** |
| Property and equipment, net |  | 1002 |
| Operating lease right-of-use assets |  | 441 |
| Other non-current assets | 10 | 91 |
| &nbsp;&nbsp;Total assets | $**51915** | $**80831** |
| ***Liabilities and shareholders' equity*** |  |  |
| Current liabilities: |  |  |
| &nbsp;&nbsp;Accounts payable | $1698 | $2722 |
| &nbsp;&nbsp;Accrued expenses and other current liabilities | 2533 | 10083 |
| &nbsp;&nbsp;Borrowings |  | 4886 |
| &nbsp;&nbsp;Current portion of operating lease liabilities |  | 315 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total current liabilities | **4231** | **18006** |
| &nbsp;&nbsp;Non-current portion of deferred revenue | 35000 | 35000 |
| &nbsp;&nbsp;Non-current portion of operating lease liabilities |  | 80 |
| &nbsp;&nbsp;Total liabilities | **39231** | **53086** |
| Commitments and contingencies (Note 8) |  |  |
| ***Shareholders' equity:*** |  |  |
| &nbsp;&nbsp;Common shares, $0.14 par value; 90,000,000 shares authorized as of September 30, 2025 and December 31, 2024; 26,305,295 shares issued and outstanding as of September 30, 2025 and December 31, 2024 | 3717 | 3717 |
| &nbsp;&nbsp;Additional paid-in capital | 213030 | 211656 |
| &nbsp;&nbsp;Accumulated deficit | (194279) | (174973) |
| &nbsp;&nbsp;Accumulated other comprehensive loss | (9784) | (12655) |
| Total shareholders' equity | 12684 | 27745 |
| **Total liabilities and shareholders' equity** | $**51915** | $**80831** |

---

*The accompanying notes are an integral part of these condensed consolidated financial statements.*

[**Table of Contents**](#TOC)

**LAVA Therapeutics N.V.**

**Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited)**

**(In thousands, except share and per share amounts)**

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **Three Months Ended** | **Three Months Ended** | **Nine Months Ended** | **Nine Months Ended** |
|  | **September 30,**  | **September 30,**  | **September 30,**  | **September 30,**  |
|  | **2025** | **2024** | **2025** | **2024** |
| *Revenue:* |  |  |  |  |
| &nbsp;&nbsp;Revenue from contracts with customers | $— | $— | $— | $6992 |
| Total revenue |  |  |  | 6992 |
| *Cost and expenses:* |  |  |  |  |
| &nbsp;&nbsp;Research and development | (2239) | (8275) | (11134) | (19881) |
| &nbsp;&nbsp;General and administrative | (5314) | (3065) | (11296) | (9881) |
| Total cost and expenses | (7553) | (11340) | (22430) | (29762) |
| Operating loss | (7553) | (11340) | (22430) | (22770) |
| *Other income (expense), net* |  |  |  |  |
| &nbsp;&nbsp;Interest income | 537 | 957 | 1857 | 2895 |
| &nbsp;&nbsp;Interest expense |  | (131) | (129) | (390) |
| &nbsp;&nbsp;Foreign currency exchange loss, net | (166) | (1719) | (3504) | (722) |
| &nbsp;&nbsp;Gain on extinguishment of borrowings |  |  | 5203 |  |
| Total other income (expense), net | 371 | (893) | 3427 | 1783 |
| Net loss before taxes | (7182) | (12233) | (19003) | (20987) |
| Income tax expense | (6) | (96) | (303) | (250) |
| **Net loss** | $**(7188)** | $**(12329)** | $**(19306)** | $**(21237)** |
| *Other comprehensive (loss) income:* |  |  |  |  |
| &nbsp;&nbsp;Foreign currency translation adjustment | (456) | 1724 | 2871 | 253 |
| **Comprehensive loss** | $**(7644)** | $**(10605)** | $**(16435)** | $**(20984)** |
| Net loss per share, basic and diluted | $(0.27) | $(0.46) | $(0.72) | $(0.79) |
| Weighted-average common shares outstanding, basic and diluted | 26899122 | 26846006 | 26895606 | 26815017 |

---

*The accompanying notes are an integral part of these condensed consolidated financial statements.*

[**Table of Contents**](#TOC)

**LAVA Therapeutics N.V.**

**Condensed Consolidated Statements of Shareholders' Equity (Unaudited)**

**(In thousands, except for share amounts)**

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **Common Shares** | **Common Shares** | | | | |
|  | **Shares** | **Amount** | <br><br>**Additional** <br>**paid-in capital** | <br>**Accumulated**<br>**deficit** | **Accumulated**<br>**other**<br>**comprehensive**<br>**loss** | <br>**Total** |
| Balance as of January 1, 2025 | 26305295 | $3717 | $211656 | $(174973) | $(12655) | $27745 |
| Share-based compensation expense |  |  | 540 |  |  | 540 |
| Foreign currency translation adjustment |  |  |  |  | 978 | 978 |
| Net loss |  |  |  | (3479) |  | (3479) |
| Balance as of March 31, 2025 | 26305295 | 3717 | 212196 | (178452) | (11677) | 25784 |
| Share-based compensation expense |  |  | 441 |  |  | 441 |
| Foreign currency translation adjustment |  |  |  |  | 2349 | 2349 |
| Net loss |  |  |  | (8639) |  | (8639) |
| Balance as of June 30, 2025 | 26305295 | 3717 | 212637 | (187091) | (9328) | 19935 |
| Share-based compensation expense |  |  | 393 |  |  | 393 |
| Foreign currency translation adjustment |  |  |  |  | (456) | (456) |
| Net loss |  |  |  | (7188) |  | (7188) |
| Balance as of September 30, 2025 | 26305295 | $3717 | $213030 | $(194279) | $(9784) | $12684 |

---

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **Common Shares** | **Common Shares** | | | | |
|  | **Shares** | **Amount** | <br><br>**Additional** <br>**paid-in capital** | <br>**Accumulated**<br>**deficit** | **Accumulated**<br>**other**<br>**comprehensive**<br>**loss** | <br>**Total** |
| Balance as of January 1, 2024 | 26289087 | $3715 | $208405 | $(149859) | $(10897) | $51364 |
| Exercise of share options | 3100 |  | 8 |  |  | 8 |
| Share-based compensation expense |  |  | 1095 |  |  | 1095 |
| Foreign currency translation adjustment |  |  |  |  | (1047) | (1047) |
| Net loss |  |  |  | (608) |  | (608) |
| Balance as of March 31, 2024 | 26292187 | 3715 | 209508 | (150467) | (11944) | 50812 |
| Exercise of share options | 5135 | 1 | 15 |  |  | 16 |
| Share-based compensation expense |  |  | 820 |  |  | 820 |
| Foreign currency translation adjustment |  |  |  |  | (424) | (424) |
| Net loss |  |  |  | (8300) |  | (8300) |
| Balance as of June 30, 2024 | 26297322 | 3716 | 210343 | (158767) | (12368) | 42924 |
| Exercise of share options | 1343 |  | 1 |  |  | 1 |
| Share-based compensation expense |  |  | 722 |  |  | 722 |
| Foreign currency translation adjustment |  |  |  |  | 1724 | 1724 |
| Net loss |  |  |  | (12329) |  | (12329) |
| Balance as of September 30, 2024 | 26298665 | $3716 | $211066 | $(171096) | $(10644) | $33042 |

---

*The accompanying notes are an integral part of these condensed consolidated financial statements.*

[**Table of Contents**](#TOC)

**LAVA Therapeutics N.V.**

**Condensed Consolidated Statements of Cash Flows (Unaudited)**

**(In thousands, except for share amounts)**

---

| | | |
|:---|:---|:---|
|  | **Nine Months Ended** | **Nine Months Ended** |
|  | **September 30,**  | **September 30,**  |
| **Cash flows from operating activities:** | **2025** | **2024** |
| Net loss | $(19306) | $(21237) |
| Adjustments to reconcile net loss to net cash used in operating activities |  |  |
| &nbsp;&nbsp;Depreciation and amortization | 118 | 357 |
| &nbsp;&nbsp;Non-cash operating lease expense | 142 | 281 |
| &nbsp;&nbsp;Foreign currency exchange loss, net | 579 | 306 |
| &nbsp;&nbsp;Share-based compensation expense | 1374 | 2637 |
| &nbsp;&nbsp;Accrued interest on borrowings | 129 | 390 |
| &nbsp;&nbsp;Amortization of premium on short-term investments |  | (2012) |
| &nbsp;&nbsp;Gain on extinguishment of borrowings | (5203) |  |
| &nbsp;&nbsp;Impairment of property and equipment and ROU asset  | 363 |  |
| &nbsp;&nbsp;Loss on the sale of property and equipment | 358 |  |
| Changes in operating assets and liabilities: |  |  |
| &nbsp;&nbsp;Prepaid expenses and other current assets | 669 | 418 |
| &nbsp;&nbsp;Other non-current assets | 87 | 230 |
| &nbsp;&nbsp;Accounts payable | (1264) | (2662) |
| &nbsp;&nbsp;Accrued expenses and other current liabilities | (8167) | 2556 |
| &nbsp;&nbsp;Operating lease liabilities | (141) | (314) |
| Net cash used in operating activities | **(30262)** | **(19050)** |
| **Cash flows from investing activities:** |  |  |
| &nbsp;&nbsp;Purchases of property and equipment |  | (23) |
| &nbsp;&nbsp;Proceeds from sale of property and equipment | 288 | 89 |
| &nbsp;&nbsp;Purchases of investments |  | (75567) |
| &nbsp;&nbsp;Maturities of investments | 40076 | 77000 |
| Net cash provided by investing activities | **40364** | **1499** |
| **Cash flows from financing activities:** |  |  |
| &nbsp;&nbsp;Proceeds from option exercises |  | 25 |
| Net cash provided by financing activities | **—** | **25** |
| Net increase (decrease) in cash and cash equivalents | **10102** | **(17526)** |
| &nbsp;&nbsp;Effects of exchange rate changes  | 4547 | 261 |
| Cash and cash equivalents at beginning of period | 35015 | 44231 |
| Cash and cash equivalents at end of period | $**49664** | $**26966** |

---

*The accompanying notes are an integral part of these condensed consolidated financial statements.*

[**Table of Contents**](#TOC)

#### Notes to the Condensed Consolidated Financial Statements (Unaudited)
1. Organization and Description of Business

#### Description of the Business
LAVA Therapeutics N.V. (the "Company") was founded in 2016 and is incorporated and domiciled in the Netherlands. The Company is a clinical-stage immuno-oncology company that has historically focused on its proprietary Gammabody® bispecific gamma delta (gd) T cell engagers to transform the treatment of cancer. Using its Gammabody platform, the Company developed a portfolio of novel bispecific antibodies designed to engage and leverage the potency and precision of gd T cells to orchestrate a robust, natural anti-tumor immune response and improve outcomes for cancer patients. The Company has collaborations with Pfizer Inc. ("Pfizer") and Johnson & Johnson ("J&J") pursuant to which Pfizer and J&J are developing potential therapeutics using the Company's Gammabody technology.

***Strategic Review Process, XOMA Transaction and EGM***

In February 2025, the board of directors of the Company (the "Board") adopted a restructuring plan (the "Restructuring Plan") to extend the Company's capital resources in connection with initiating a process to evaluate potential strategic alternatives such as a reverse merger, other business combination, dissolution and wind-down, or cash sale transaction.

On August 3, 2025, the Company entered into a share purchase agreement with XOMA Royalty Corporation, a Nevada corporation ("XOMA"). The share purchase agreement (as subsequently amended, the "Purchase Agreement") provides for, among other things, the acquisition of all of the Company's issued and outstanding common shares, par value €0.12 per share, by XOMA through a tender offer, for a cash amount plus one contingent value right ("CVR") per share, which represents the right to receive potential payments, in cash, described in, and subject to and in accordance with the terms and conditions of, a contingent value rights agreement (as amended to date, the "CVR Agreement") (collectively, the "XOMA Transaction").

The Purchase Agreement was amended on October 17, 2025, as described in greater detail in the Company's Current Report on Form 8-K filed on October 17, 2025. Pursuant to the amendment, holders of common shares of the Company (the "Shares", and such holders, the "Shareholders") who tender their Shares in the tender offer (the "Offer") will now receive (i) a price per Share of $1.04 plus (ii) one CVR. Pursuant to the revised form of CVR Agreement under the amendment, each CVR will now represent a contractual right to receive contingent cash payments equal to a pro rata share of: (i) 100% of the amount by which the Closing Net Cash (as defined in the Purchase Agreement), as adjusted for any Permitted Deductions (as defined in the CVR Agreement) made within ninety (90) days following the Closing Date (as defined in the Purchase Agreement), exceeds Closing Net Cash as finally determined pursuant to the Purchase Agreement; (ii)(A) 100% of the Net Proceeds (as defined in the CVR Agreement), if any, from any sale, transfer, license or other disposition (each, a "Disposition") by the Company, of all or any part of the rights, intellectual property and other assets related to LAVA-1266 prior to the Closing Date; plus (B) 75% of the Net Proceeds, if any, from any Disposition by Buyer or any of its affiliates, including the Company, after, of all or any part of the CVR Products (as defined in the CVR Agreement) entered into following the Closing Date, in each case for the period beginning at the Closing Date and ending on the 10<sup>th</sup> anniversary of the Closing Date; (iii) 75% of the Net Proceeds, in the case of Gross Proceeds as payable to XOMA or any of its affiliates, including the Company (after the Closing Date), or is otherwise due to or received by Buyer or any of its Affiliates, including the Company (after the Closing Date) and New Topco, in respect of the Company's collaborations with Pfizer and J&J for the period beginning at the Closing Date and ending on the 10<sup>th</sup> anniversary of the Closing Date; and (iv) 100% of an amount equal to $6,330,000, minus any tax liabilities or other costs or expenses incurred in connection with or related to the Tax Reserve Matter (as defined in the CVR Agreement), for the period beginning at the Closing Date and ending no later than sixty (60) days following the Tax Reserve Confirmation Date (as defined in the CVR Agreement). In addition, in the amendment, the Company and XOMA agreed to

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reduce the minimum Closing Net Cash (as defined in the Purchase Agreement), which is a condition to the consummation of the Offer, from $31.5 million to $24.5 million.

If the Purchase Agreement is terminated by the Company under certain circumstances specified in the Purchase Agreement, including in connection with the Company's entry into an agreement with respect to a Superior Proposal (as such term is defined in the Purchase Agreement), the Company would be required to pay XOMA a termination fee of $0.75 million.

On October 17, 2025, the Company and XOMA issued a joint press release announcing the execution of the amendment and an extension of the expiration of the Offer to one minute after 11:59 p.m., New York City time, on November 12, 2025, unless it is extended further or earlier terminated in accordance with the Purchase Agreement. The joint press release also announced the Company's intention to reconvene the Extraordinary General Meeting of Shareholders (the "EGM") at 2:00 p.m. (Central European Summer Time) on November 7, 2025. The Company's future operations are highly dependent on the success of the XOMA Transaction and there can be no assurances that the XOMA Transaction will be successfully consummated. In the event that the Company does not complete the XOMA Transaction, the Company may explore strategic alternatives, including, without limitation, another strategic transaction and/or pursue dissolution and liquidation of the Company.

As part of the Restructuring Plan, the Company reduced its workforce by approximately 71% to a total of 10 full-time employees as of September 30, 2025. The Company intends to retain all employees essential for fulfilling the Company's SEC reporting obligations and supporting value realization as part of the XOMA Transaction.

#### Liquidity and Going Concern
In accordance with Accounting Standards Codification ("ASC") 205-40, *Going concern*, the Company has evaluated whether there are conditions and events, considered in the aggregate, that raise substantial doubt about the Company's ability to continue as a going concern within one year after the date the condensed consolidated financial statements are issued. The Company has incurred net losses since inception, and the Company expects to continue to generate operating losses in the foreseeable future. As of September 30, 2025, the Company had an accumulated deficit of $194.3 million. Management expects to incur additional losses in the foreseeable future.

The Company has devoted, and expects to continue to devote, substantial time and resources to complete the XOMA Transaction as further described above. The Company expects that the XOMA Transaction will close in the fourth quarter of 2025. There can be no assurances that the XOMA Transaction will be successfully consummated.

Through September 30, 2025, the Company has funded its operations with proceeds from equity financings, collaboration and licensing agreements, government grants, and borrowings under various agreements. The Company does not intend to raise the additional capital that would otherwise be required to support the completion of its research and development activities, due to the Company currently winding down its programs. As noted in Note 11, as of August 2025, the Company announced its intent to discontinue the LAVA-1266 program and is in process of discontinuing the LAVA-1266 program as of September 30, 2025. The Company has not incurred any new material financial obligations with respect to the termination of this program.

As of the issuance date of the condensed consolidated financial statements, the Company believes that its cash and cash equivalents will be sufficient to fund its planned expenditures and meet its obligations for at least the next twelve months from the issuance date of these condensed consolidated financial statements.

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2. Summary of Significant Accounting Policies

The significant accounting policies and estimates used in the preparation of the accompanying unaudited condensed consolidated financial statements are described in the Company's audited consolidated financial statements for the year ended December 31, 2024 included in the Company's Annual Report on Form 10-K filed with the SEC on March 28, 2025. There have been no material changes in the Company's significant accounting policies during the three and nine months ended September 30, 2025.

***Unaudited Interim Financial Information***

The accompanying unaudited condensed consolidated financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America ("U.S. GAAP") as issued by the Financial Accounting Standards Board (the "FASB") and include the operations of LAVA Therapeutics N.V. and its wholly-owned subsidiaries. All intercompany accounts, transactions and balances have been eliminated in consolidation.

In the opinion of the Company, the accompanying unaudited condensed consolidated financial statements contain all adjustments, consisting of only normal recurring adjustments, necessary for a fair statement of its financial position as of September 30, 2025, its results of operations for the three and nine months ended September 30, 2025 and 2024, and its cash flows for the nine months ended September 30, 2025 and 2024. The condensed balance sheet at December 31, 2024, was derived from audited annual financial statements but does not contain all of the footnote disclosures from the annual financial statements.

The results for the three and nine months ended September 30, 2025 are not necessarily indicative of results to be expected for the full year or for any other subsequent interim period.

***Basis of Presentation***

The Company had historically been classified as a foreign private issuer ("FPI"). However, as of June 30, 2024, the Company determined that, pursuant to the definition provided in Rule 405 of the Securities Act of 1933, it no longer satisfied the criteria to be considered an FPI. As such, beginning on January 1, 2025, the Company was required to begin reporting with the U.S. Securities and Exchange Commission on domestic forms and comply with domestic company rules in the United States. The Company retrospectively made the transition from International Financial Reporting Standards ("IFRS") to U.S. GAAP for all periods from the Company's inception.

***Cash and Cash Equivalents***

The Company's cash equivalents consist of highly liquid investments with remaining maturities at the date of purchase of three months or less.

The Company makes short-term deposits for varying periods of between one day and three months, depending on the Company's immediate cash requirements. The deposits earn interest at the respective short-term deposit rates. The Company's cash and cash equivalents balances as of September 30, 2025 and December 31, 2024, included $49.7 million and $35.0 million, respectively, of short-term bank deposits.

The Company did not have any restricted cash as of September 30, 2025 or December 31, 2024.

***Short-term Investments***

The Company's investments consist only of holdings in U.S. Treasury debt securities with maturities ranging from three months to one year. Accordingly, the Company classifies these investments as current assets in its consolidated balance sheets. Because the Company has the intent and ability to hold these investments until maturity, the Company classifies its short-term investments in U.S. Treasury debt

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securities as held to maturity ("HTM") and thus measures the investments at amortized cost. These assets are classified as Level 1 within the fair value hierarchy as there are quoted prices for identical assets in active markets.

The Company estimates the allowance for credit losses on its HTM debt securities using a current expected credit loss methodology. The Company deducts any expected credit loss on its HTM debt securities from the amortized cost basis of the securities so that the condensed consolidated balance sheets reflect the net amount the Company expects to collect. All of the Company's HTM debt securities are issued by the U.S. Treasury, a department of the U.S. government. U.S. Treasury debt securities are either explicitly or implicitly guaranteed by the U.S. government, are highly rated by major rating agencies, and have a long history of no credit losses. Accordingly, the Company has a zero-credit loss expectation on these securities.Therefore, as of December 31, 2024, the Company did not record an allowance for credit losses on its short-term investments. The amortized cost basis of the Company's HTM debt securities is $41.6 million as of December 31, 2024. As of December 31, 2024, the difference between the amortized cost basis and fair value is less than $0.1 million.

The Company records the amortization of premiums or discounts in the condensed consolidated statements of operations and comprehensive loss within interest income and interest expense, respectively.

#### New Accounting Pronouncements – Not Yet Adopted
In December 2023, the FASB issued ASU *No. 2023-09, Income Taxes (ASC Topic 740): Improvements to Income Tax Disclosures* ("ASU 2023-09"), which establishes incremental disaggregation of income tax disclosures pertaining to the effective tax rate reconciliation and income taxes paid. The amendments in this update apply to all entities that are subject to ASC Topic 740, *Income Taxes*. For public business entities, the amendments in this update are effective for annual periods beginning after December 15, 2024, and early adoption is permitted. The Company has evaluated the impact of the provisions of the amendments that will change the annual tax footnote disclosures and is considering whether it will adopt prospectively or retrospectively.

In November 2024, the FASB issued *ASU No. 2024-03, Disaggregation of Income Statement Expenses (DISE)* ("ASU 2024-03"), requiring additional disclosure of the nature of expenses included in the income statement. The new standard requires disclosures about specific types of expenses included in the expense captions presented on the face of the condensed consolidated statements of operations and comprehensive loss as well as disclosures about selling expenses. The amendment in this update applies to all public business entities and is effective for annual reporting periods beginning after December 15, 2026 and interim reporting periods beginning after December 15, 2027. The Company is currently evaluating the provisions of the amendments and the impact on its disclosures.

3. Revenue

The Company does not currently have any commercial sales. The Company has entered into collaboration and licensing arrangements for research and development, manufacturing, and commercialization activities with counterparties for the development and commercialization of its product candidates. These arrangements contain multiple promised goods and services, such as licenses, research and development activities, and the manufacturing of certain materials. Payments pursuant to these arrangements include non-refundable payments upon the achievement of significant regulatory, development and commercial milestones, sales of product at certain agreed-upon amounts, and royalties on product sales.

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The following table presents the components of the Company's revenue:

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| | | |
|:---|:---|:---|
| | **Nine Months Ended**  | **Nine Months Ended**  |
| | **September 30,**  | **September 30,**  |
| <br>***(in thousands)*** | **2025** | **2024** |
| Pfizer Inc. - Pfizer Agreement - Agreed-to reimbursement activities | $— | $24 |
| Pfizer Inc. - Pfizer Agreement - Development milestones |  | 6960 |
| Pfizer Inc. - Additional services |  | 8 |
| Total revenue from contracts with customers | $**—** | $**6992** |

---

#### Pfizer Agreement
In September 2022, the Company entered into a license agreement with Pfizer (formally Seagen Inc.) ("Pfizer") to develop, manufacture, and commercialize PF-08046052 (formerly LAVA-1223), an advanced preclinical asset that utilizes the Company's proprietary Gammabody technology to target EGFR-positive tumors (the "Pfizer Agreement"). Under the terms of the Pfizer Agreement, the Company received a $50.0 million nonrefundable upfront payment in October 2022 and could receive up to approximately $650.0 million in potential development, regulatory, and commercial milestones, and royalties ranging from high single-digit to mid-teen percentages on future sales. The Pfizer Agreement also provided Pfizer with the opportunity to exclusively negotiate rights to apply the Company's proprietary Gammabody platform on up to two additional tumor targets, although these rights expired during the year ended December 31, 2024. In March 2024, Pfizer achieved a clinical development milestone for PF-08046052, resulting in the first milestone payment of $7.0 million to the Company under the Pfizer Agreement, which was recognized in revenue during the nine months ended September 30, 2024.

Under the Pfizer Agreement, the Company was also entitled to receive reimbursement of up to $6.5 million for certain agreed-to research, manufacturing, and supply activities, as well as the transfer of all manufacturing-related know-how and materials, including all CMC documentation, data, and processes, to enable the manufacture of licensed compounds and products by Pfizer. As of December 31, 2024, the Company has recognized an aggregate of $6.4 million for additional agreed-to services requested by Pfizer. The Company did not recognize any revenue related to the reimbursement of additional agreed-to services requested by Pfizer during the three months ended September 30, 2025 or 2024. For the nine months ended Sepember 30, 2024, the Company recognized less than $0.1 million related to the reimbursement of additional agreed-to services requested by Pfizer. The Company did not recognize any revenue related to the reimbursement of additional agreed-to services requested by Pfizer during the nine months ended September 30, 2025. The Company does not anticipate receiving reimbursement for any additional agreed-to services at this time.

*Deferred Revenue*

The Company determined that the one-time buy-up fee of $35.0 million represents a variable consideration and not a performance obligation, for which it has deferred revenue recognition until such time the option expires or the Company exercises the option. The Company allocated the variable consideration from the buy-up fee to the license performance obligation as it aligns with the economic substance of the Pfizer Agreement. The Company received the non-refundable upfront payment of $50.0 million in October 2022, and recorded the variable consideration of $35.0 million as a deferred revenue liability. The balance as of September 30, 2025 and December 31, 2024 was $35.0 million. If the Company does not exercise the buy-up option and the option expires or is otherwise waived by the

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Company, the Company will recognize the revenue related to the license performance obligation as there are no remaining performance obligations.

4. Accrued Expenses and Other Current Liabilities

The following table presents the components of the Company's accrued expenses and other current liabilities:

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| | | |
|:---|:---|:---|
| <br>***(in thousands)*** | **September 30,**<br>**2025** | **December 31,**<br>**2024** |
| Personnel-related expenses | $1109 | $1398 |
| Employee termination benefits | 564 |  |
| Research and development external project costs | 360 | 7138 |
| Professional fees | 126 | 598 |
| Income taxes |  | 335 |
| Other | 374 | 614 |
|  | $2533 | $10083 |

---

5. Restructuring

In February 2025, the Company adopted a restructuring plan to extend its capital resources in connection with initiating a process to evaluate strategic alternatives (the "Restructuring Plan"). As part of the Restructuring Plan, the Company approved a reduction of approximately 30% of the global workforce to better align the Company's resources with its then-focus on the LAVA-1266 program. Since that time, the Company has executed further initiatives in relation to the initial Restructuring Plan. On April 18, 2025, the Company entered into an agreement to terminate the operating lease arrangement effective May 1, 2025 for laboratory and office space in Utrecht, the Netherlands and sell a portion of the remaining fixed assets to the landlord and new tenant. On May 12, 2025, the Board approved the reduction of all of the workforce remaining in the Netherlands by July 31, 2025 and the termination of its lease arrangement in Den Bosch, the Netherlands effective August 1, 2025. Further, on July 23, 2025, the Company entered into an agreement to terminate its short-term lease arrangement effective September 30, 2025 for office space in Philadelphia, Pennsylvania.

The Company incurred the following restructuring and impairment charges for the three months ended September 30, 2025, of which $0.6 million and less than $0.1 million are recorded in research and development and general and administrative expenses, respectively, in the consolidated statement of operations and comprehensive loss:

---

| | |
|:---|:---|
| <br>***(in thousands)*** | **Three Months Ended**<br>**September 30, 2025** |
| Employee termination benefits | $609 |
| Impairment charges | 39 |
| Total restructuring and impairment charges  | $648 |

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The Company incurred the following restructuring and impairment charges for the nine months ended September 30, 2025, of which $3.2 million and $0.7 million are recorded in research and development and general and administrative expenses, respectively, in the consolidated statement of operations and comprehensive loss:

---

| | |
|:---|:---|
| <br>***(in thousands)*** | **Nine Months Ended**<br>**September 30, 2025** |
| Employee termination benefits | $2576 |
| Costs for terminated contracts | 579 |
| Loss on sale of fixed assets | 358 |
| Impairment charges | 362 |
| Total restructuring and impairment charges  | $3875 |

---

The actions associated with the Restructuring Plan commenced in February 2025 and are expected to be completed by the end of 2025.

***Employee Termination Benefits***

Employees affected by the Restructuring Plan received involuntary termination benefits pursuant to a one-time benefit for a set period of time. Employees who were notified of their termination in 2025 had no requirements to provide future services beyond the minimum retention period. As such, the Company recognized the liability for the termination benefits in full at fair value at the date of communication to the employee.

The following table shows the liability related to employee termination benefits as of September 30, 2025:

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| | |
|:---|:---|
| <br>***(in thousands)*** | **September 30,**<br>**2025** |
| Accrued employee termination benefits as of January 1, 2025 | $— |
| Employee termination benefits charges incurred during the period | 2576 |
| Amounts paid or otherwise settled during the period | (2012) |
| Accrued employee termination benefits as of September 30, 2025 | $564 |

---

The Company does not anticipate incurring any additional costs as part of the workforce reduction.

***Costs for Terminated Contracts***

The Restructuring Plan resulted in contract termination costs from vendor contracts before the end of their term. In accordance with ASC 420, *Exit or Disposal Cost Obligations*, the Company recognized these unavoidable contract costs when incurred.

The following table shows the liability related to costs for contract termination costs as of September 30, 2025:

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| | |
|:---|:---|
| <br>***(in thousands)*** | **September 30,**<br>**2025** |
| Accrued contract costs as of January 1, 2025 | $— |
| Contract costs incurred during the period | 579 |
| Amounts paid or otherwise settled during the period | (579) |
| Accrued contract costs as of September 30, 2025 | $— |

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***Loss on Sale of Fixed Assets and Impairment Charges***

In conjunction with the Restructuring Plan and the agreements to terminate the operating lease arrangement for laboratory and office space in Utrecht, the Netherlands, effective May 1, 2025 and to terminate the lease arrangement in Den Bosch, the Netherlands effective August 1, 2025, the Company disposed of fixed assets through sale and abandonment. The Company recorded a loss of $0.4 million, net of proceeds of $0.3 million from the sale of fixed assets, which was recorded in research and development expenses in the condensed consolidated statement of operations and comprehensive loss for the nine months ended September 30, 2025.

Additionally, the Company evaluated certain other fixed assets, leasehold improvements, and right of use assets associated with the laboratory and office space in Utrecht, the Netherlands and Den Bosch, the Netherlands and concluded that it would abandon the fixed assets, leasehold improvements, and right of use assets in the three months ended June 30, 2025, and as a result, the Company incurred $0.3 million in impairment charges, of which $0.2 million and less than $0.1 million were recorded in research and development and general and administrative expenses, respectively, in the condensed consolidated statement of operations and comprehensive loss for the nine months ended September 30, 2025.

Further, the Company abandoned less than $0.1 million of fixed assets associated with the office space in Philadelphia, Pennsylvania in the three months ended September 30, 2025, and as a result incurred less than $0.1 million in impairment charges in general and administrative expenses in the condensed consolidated statement of operations and comprehensive loss for the three and nine months ended September 30, 2025.

6. Discontinuation of Clinical Trials

In December 2024, the Company announced that the clinical trial of LAVA-1207 targeting prostate specific membrane antigen-expressing cancers for patients with metastatic castration resistant prostate cancer was no longer recruiting and would be discontinued after no patients remain on treatment. The Company was evaluating LAVA-1207 in an open-label, multi-center Phase 1 clinical trial to evaluate safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity and preliminary anti-tumor activity of LAVA-1207 and to determine recommended dose(s) for optimization in a Phase 2a clinical trial. The Company made the decision to discontinue the LAVA-1207 development program, as the Phase 1 trial did not reach the Company's internal benchmarks. The decision was not due to safety concerns. The discontinuation was in process as of September 30, 2025. As a result of the discontinuation, the Company accrued $3.9 million as of December 31, 2024 and $0.3 million as of September 30, 2025 for costs associated with clinical trial, contract manufacturing, and bioanalytical activities for LAVA-1207. During the nine months ended September 30, 2025 the Company paid $3.3 million and negotiated a reduction in a contract resulting in an update to the estimate for remaining costs of $0.3 million. The Company expects to pay or settle the remaining amount during the year ending December 31, 2025. The Company reviewed the relevant items of its condensed consolidated balance sheets and did not identify any asset that would require impairment as a result of the discontinuation of the clinical trial of LAVA-1207.

In August 2025, the Company announced its decision to discontinue its Phase 1 clinical trial of LAVA-1266 for acute myeloid leukemia and myelodysplastic syndrome and initiate the wind-down of the LAVA-1266 program and the discontinuation was in process as of September 30, 2025. As a result of the discontinuation, the Company incurred costs of $0.3 million which were paid out during the three months ended September 30, 2025. The Company reviewed the relevant items of its condensed consolidated balance sheets and did not identify any asset that would require impairment as a result of the discontinuation of the clinical trial of LAVA-1266.

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7. Borrowings

In 2019, the Company applied for and received a $5.5 million Innovation Credit (the "Credit") from Rijksdienst voor Ondernemend Nederland ("RVO"). The Credit contributed to the development of LAVA-051, and the Company pledged certain assets of that project as a guarantee.

Borrowings under the Credit bore interest at 10.0% and were received in quarterly installments, based on the level of the underlying cost base of the project in each period.

In March 2025, the Company received notice from the RVO that repayment of the remaining loan balance of $5.2 million had been permanently waived. The Company recognized a gain on extinguishment within other income (expense), net in the condensed consolidated statements of operations and comprehensive loss during the nine months ended September 30, 2025.

The Company recognized interest expense related to the Credit of $0.1 million for the three months ended September 30, 2024, and $0.1 million and $0.4 million for the nine months ended September 30, 2025 and 2024, respectively.

8. Commitments and Contingencies

The Company accrues for contingency liabilities, including those involving general liability, workers' compensation, and other matters, when it is probable that the Company will incur and can reasonably estimate future costs (including legal fees and expenses). The Company bases the accruals on developments to date, management's estimates of the outcomes of these matters, and the Company's experience in contesting, litigating, and settling similar matters. The Company reviews its legal contingencies at each reporting period and adjusts the liabilities to reflect the current best estimate. The Company was not party to any pending legal proceedings or claims as of September 30, 2025 or December 31, 2024. Other than the Amsterdam UMC Agreement described below, the Company has not made any material commitments.

*Amsterdam UMC Agreement*

In January 2017, the Company entered into an agreement with the Amsterdam UMC (the "Amsterdam UMC Agreement") under which Amsterdam UMC granted the Company an exclusive (although non-exclusive with respect to certain intangible know-how), worldwide, sublicensable license for certain patent rights and know-how owned by Amsterdam UMC, effectively including research and other services provided in collaboration by Amsterdam UMC to develop, make, and sell licensed products related to such patent rights and know-how. Amsterdam UMC retains the right to use the patent rights and know-how for solely non-commercial research and educational purposes, but it may not conduct such work with respect to any product that is directed to a specified target for a specified time period.

The Company is obligated to pay Amsterdam UMC low single-digit tiered royalties on net sales of products covered by claims included in the assigned patent rights. The Company has not incurred or paid royalties to Amsterdam UMC at this time, as there have been no net sales of the products covered by the claims. Royalties are payable on a country-by-country basis for a royalty term that expires upon the expiration of the last valid claim in the assigned patent rights in such country that would be infringed by the use, manufacture, or sale of a product in such country in the absence of the Company having rights to such patent right.

9. Earnings Per Share (EPS)

The Company calculates basic EPS by dividing the loss for the period attributable to common equity holders of the parent by the weighted average number of common shares outstanding during the period. The Company accounts for vested share-based awards that are issued for little to no consideration, as issuable common shares. As the share options under the 2018 Stock Option Plan have an exercise price

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of little to no consideration, the Company considers these share options to be issuable common shares, and therefore, included these options in the common shares outstanding.

The Company calculates diluted EPS by dividing the loss attributable to common equity holders of the parent (after adjusting for the effect of dilution) by the weighted average number of common shares outstanding, adjusted for the effects of potentially dilutive share-based awards.

As of September 30, 2025 and 2024, the Company had potentially dilutive share-based options of 6,945,862 and 5,984,268, respectively. The Company excluded these awards from the calculation of the diluted weighted average number of common shares outstanding because their effect on the loss per share would have been anti-dilutive as the Company was in a net loss position in both periods.

10. Segment Information

The Company identifies operating segments based on whether the Company's Chief Executive Officer, who is the Chief Operating Decision Maker ("CODM"), regularly reviews the allocation of resources and/or the assessment of performance of a particular component of the Company's activities. The Company has one reportable segment – the development of the Gammabody platform of bispecific gd T cell engagers for the treatment of cancer.

The CODM assesses performance for the segment and decides how to allocate resources based on net loss that also is reported on the condensed consolidated statements of operations and comprehensive loss. Significant expenses within the condensed consolidated statements of operations and comprehensive loss, as well as within net loss, include research and development, and general and administrative expenses, which are each separately presented on the Company's condensed consolidated statements of operations and comprehensive loss. Other segment items within net loss include other income (expense), net, and income tax expense, net. In the context of considerations around significant segment expenses, as the expense information that is regularly provided to the CODM is aligned with the consolidated expenses as presented on the statements of operations and comprehensive loss, such expense disclosures are not replicated here.

Net loss is used to monitor budget versus actual results. The monitoring of budgeted versus actual results are used in assessing performance of the segment and in part determining management's compensation. The CODM also analyzes forecasted general and administrative and research and development expenses when assessing the performance of the segment.

All assets, liabilities, cash flows, revenue and expenses are reported on the Company's one reportable segment.

11. Subsequent Events

*Amendment to Share Purchase Agreement with XOMA*

On October 17, 2025, the Company entered into the Amendment to the Purchase Agreement, as described in greater detail in the Company's Current Report on Form 8-K filed on October 17, 2025. Pursuant to the Amendment, holders who tender their Shares in the Offer will now receive (i) a price per Share of $1.04 plus (ii) one CVR. Pursuant to the revised form of CVR Agreement under the amendment, each CVR will now represent a contractual right to receive contingent cash payments equal to a pro rata share of: (i) 100% of the amount by which the Closing Net Cash (as defined in the Purchase Agreement), as adjusted for any Permitted Deductions (as defined in the CVR Agreement) made within ninety (90) days following the Closing Date (as defined in the Purchase Agreement), exceeds Closing Net Cash as finally determined pursuant to the Purchase Agreement; (ii)(A) 100% of the Net Proceeds (as defined in the CVR Agreement), if any, from any Disposition by the Company, of all or any part of the rights, intellectual property and other assets related to LAVA-1266 prior to the Closing Date; plus (B) 75% of the Net Proceeds, if any, from any Disposition by Buyer or any of its affiliates, including the Company, after,

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of all or any part of the CVR Products (as defined in the CVR Agreement) entered into following the Closing Date, in each case for the period beginning at the Closing Date and ending on the 10<sup>th</sup> anniversary of the Closing Date; (iii) 75% of the Net Proceeds, in the case of Gross Proceeds as payable to XOMA or any of its affiliates, including the Company (after the Closing Date), or is otherwise due to or received by Buyer or any of its Affiliates, including the Company (after the Closing Date) and New Topco, in respect of the Company's collaborations with Pfizer and J&J for the period beginning at the Closing Date and ending on the 10<sup>th</sup> anniversary of the Closing Date; and (iv) 100% of an amount equal to $6,330,000, minus any tax liabilities or other costs or expenses incurred in connection with or related to the Tax Reserve Matter (as defined in the CVR Agreement), for the period beginning at the Closing Date and ending no later than sixty (60) days following the Tax Reserve Confirmation Date (as defined in the CVR Agreement). In addition, in the amendment, the Company and XOMA agreed to reduce the minimum Closing Net Cash (as defined in the Purchase Agreement), which is a condition to the consummation of the Offer, from $31.5 million to $24.5 million.

On October 17, 2025, the Company and XOMA issued a joint press release announcing the execution of the Amendment and an extension of the expiration of the Offer to one minute after 11:59 p.m., New York City time, on November 12, 2025, unless it is extended further or earlier terminated in accordance with the Purchase Agreement. The joint press release also announced the Company's intention to reconvene the Extraordinary General Meeting of Shareholders (the "EGM") at 2:00 p.m. (Central European Summer Time) on November 7, 2025.

#### Item 2. Management's Discussion and Analysis of Financial Condition and Results of Operations
***You should read the following discussion and analysis of our financial condition and results of operations together with our unaudited condensed consolidated financial statements and related notes and other financial information included elsewhere in this Quarterly Report, and the audited consolidated financial statements and notes thereto as of and for the year ended December 31, 2024 and the related Management's Discussion and Analysis of Financial Condition and Results of Operations included in our Annual Report on Form 10-K filed with the SEC on March 28, 2025. Some of the information contained in this discussion and analysis or set forth elsewhere in this Quarterly Report, including information with respect to our plans and strategy for our business and related financing, includes forward-looking statements that involve risks and uncertainties. As a result of many factors, including those factors set forth in the "Special Note Regarding Forward-Looking Statements" and "Risk Factors" sections of this Quarterly Report and in our most recent Annual Report on Form 10-K, our actual results could differ materially from the results described in or implied by the forward-looking statements contained in the following discussion and analysis. Unless the context requires otherwise, references in this Quarterly Report to the "Company," "we," "us," and "our" refer to LAVA Therapeutics N.V. and its subsidiaries.***

#### Overview
We are a clinical-stage immuno-oncology company that has historically focused on our proprietary Gammabody® bispecific gamma delta (gd) T cell engagers to transform the treatment of cancer. Our collaborators are currently advancing our Gammabody pipeline for the development of potential therapeutics in both hematologic malignancies and solid tumors through two partnered programs:

● JNJ-89853413, targeting CD33 and hematologic cancers (NCT06618001), partnered with Johnson & Johnson, and

● PF-08046052, targeting EGFR-positive tumors (NCT05983133), partnered with Pfizer, Inc.

***Strategic Review Process***

In February 2025, our board of directors (the "Board") adopted a restructuring plan (the "Restructuring Plan") to extend our capital resources in connection with initiating a process to evaluate potential strategic alternatives such as a reverse merger, other business combination, dissolution and wind-down, or cash

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sale transaction. As a result of this strategic review process, we entered into the Purchase Agreement (as described below).

***Purchase Agreement; Tender Offer***

On August 3, 2025, we entered into a share purchase agreement with XOMA Royalty Corporation, a Nevada corporation ("XOMA"). The share purchase agreement (as subsequently amended, the "Purchase Agreement") provides for, among other things, the acquisition of all of the Company's issued and outstanding common shares, par value €0.12 per share, by XOMA through a tender offer, for a cash amount plus one contingent value right ("CVR") per share, which represents the right to receive potential payments, in cash, described in, and subject to and in accordance with the terms and conditions of, a contingent value rights agreement (as amended to date, the "CVR Agreement") (collectively, the "XOMA Transaction").

The Purchase Agreement was amended on October 17, 2025, as described in greater detail in the Company's Current Report on Form 8-K filed on October 17, 2025. Pursuant to the amendment, holders of common shares of the Company (the "Shares," and such holders, the "Shareholders") who tender their Shares in the tender offer (the "Offer") will now receive (i) a price per Share of $1.04 plus (ii) one CVR. Pursuant to the revised form of CVR Agreement under the amendment, each CVR will now represent a contractual right to receive contingent cash payments equal to a pro rata share of: (i) 100% of the amount by which the Closing Net Cash (as defined in the Purchase Agreement), as adjusted for any Permitted Deductions (as defined in the CVR Agreement) made within ninety (90) days following the Closing Date (as defined in the Purchase Agreement), exceeds Closing Net Cash as finally determined pursuant to the Purchase Agreement; (ii)(A) 100% of the Net Proceeds (as defined in the CVR Agreement), if any, from any sale, transfer, license or other disposition (each, a "Disposition") by the Company, of all or any part of the rights, intellectual property and other assets related to LAVA-1266 prior to the Closing Date; plus (B) 75% of the Net Proceeds, if any, from any Disposition by Buyer or any of its affiliates, including the Company, after, of all or any part of the CVR Products (as defined in the CVR Agreement) entered into following the Closing Date, in each case for the period beginning at the Closing Date and ending on the 10<sup>th</sup> anniversary of the Closing Date; (iii) 75% of the Net Proceeds, in the case of Gross Proceeds as payable to XOMA or any of its affiliates, including the Company (after the Closing Date), or is otherwise due to or received by Buyer or any of its Affiliates, including the Company (after the Closing Date) and New Topco, in respect of the Company's collaborations with Pfizer and J&J for the period beginning at the Closing Date and ending on the 10<sup>th</sup> anniversary of the Closing Date; and (iv) 100% of an amount equal to $6,330,000, minus any tax liabilities or other costs or expenses incurred in connection with or related to the Tax Reserve Matter (as defined in the CVR Agreement), for the period beginning at the Closing Date and ending no later than sixty (60) days following the Tax Reserve Confirmation Date (as defined in the CVR Agreement). In addition, in the amendment, the Company and XOMA agreed to reduce the minimum Closing Net Cash (as defined in the Purchase Agreement), which is a condition to the consummation of the Offer, to be from $31.5 million $24.5 million.

XOMA's obligation to purchase the shares pursuant to the Offer is subject to the satisfaction or waiver of various usual and customary conditions as described further in our Current Reports on Form 8-K filed with the Securities and Exchange Commission on August 4, 2025, October 17, 2025 and the documents filed as exhibits thereto. The terms of the revised CVR Agreement are also set forth in more detail in our Current Report on Form 8-K filed with the Securities and Exchange Commission on October 17, 2025. See also Item 1 of Part I, "Notes to Condensed Consolidated Financial Statements — Note 1- Organization and Description of Business and Note 11 — Subsequent Events" of this Quarterly Report for further details.

***Decision to Discontinue Phase 1 Trial of LAVA-1266***

On August 4, 2025, we announced our decision to discontinue our Phase 1 clinical trial of LAVA-1266 for acute myeloid leukemia and myelodysplastic syndrome and initiate the wind-down of the LAVA-1266 program. As a result of the discontinuation, the Company incurred costs of $0.3 million which were paid out during the three months ended September 30, 2025.

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***Restructuring Plan***

On February 20, 2025, our Board adopted a Restructuring Plan to extend our capital resources in connection with initiating a process to evaluate strategic alternatives. As part of the Restructuring Plan, we approved a workforce reduction of approximately 30% of the global workforce to better align our resources with our then-focus on our LAVA-1266 program. During the three months ended March 31, 2025, we recognized $0.5 million of expenses associated with the workforce reduction, of which $0.4 million was recorded within research and development expense and less than $0.1 million was recorded within general and administrative expense in our condensed consolidated statements of operations and comprehensive loss.

On April 18, 2025, we entered into an agreement to terminate our operating lease arrangement for laboratory and office space in Utrecht, the Netherlands and sell a portion of the remaining fixed assets to the landlord and new tenant. We incurred $1.0 million of expenses associated with the lease termination during the three months ended June 30, 2025, net of $0.3 million of proceeds received from the sale of the assets, of which $0.8 million was recorded within research and development expense and $0.2 million was recorded within general and administrative expense in our condensed consolidated statements of operations and comprehensive loss.

On May 13, 2025, the Board extended the Restructuring Plan in connection with the ongoing process to evaluate strategic alternatives and better align our resources with our then-focus on our LAVA-1266 program. As part of the Restructuring Plan, the Board approved the elimination of the positions of our remaining Netherlands employees by July 31, 2025 and the termination of our lease arrangement in Den Bosch, the Netherlands effective August 1, 2025. We incurred $1.7 million of expenses related to this additional restructuring during the three months ended June 30, 2025, of which $1.3 million was recorded within research and development expense and $0.4 million was recorded within general and administrative expense in our condensed consolidated statements of operations and comprehensive loss.

On July 23, 2025, we entered into an agreement to terminate our short-term lease arrangement for office space in Philadelphia, Pennsylvania. As a result of this termination, we sold a portion of the remaining fixed assets and eliminated the positions of certain employees. We incurred $0.6 million of expenses related to this additional restructuring during the three months ended September 30, 2025, of which $0.6 million was recorded within research and development expense and less than $0.1 million was recorded within general and administrative expense in our condensed consolidated statements of operations and comprehensive loss.

#### Key Components of Our Results of Operations

#### Revenue
To date, we have not generated any revenues from product sales, and we do not expect to generate any revenue from the sale of products in the future. If our collaborators' development efforts result in clinical success and regulatory approval, we may generate revenue from such collaboration agreements, as described in more detail below. Upon completion of of the XOMA Transaction, such revenue would result in proceeds under the CVRs held by our shareholders.

*Collaboration Agreement with Pfizer*

In September 2022, we entered into an exclusive license agreement with Pfizer (formerly Seagen Inc.) (the "Pfizer Agreement") to develop, manufacture and commercialize PF-8046052 (formerly LAVA-1223), an advanced preclinical asset that utilizes our proprietary Gammabody technology to target EGFR-positive tumors. Under the Pfizer Agreement, we received a $50.0 million nonrefundable upfront payment in October 2022 and are eligible to receive up to approximately $650.0 million upon the achievement of development, regulatory and commercial milestones, as well as royalties ranging from the low teens to high mid-teens on future sales. The Pfizer Agreement also provided Pfizer with the opportunity to exclusively negotiate rights to apply our proprietary Gammabody platform on up to two additional tumor

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targets, which Pfizer did not exercise. In March 2024, Pfizer paid us $7.0 million for achieving a clinical milestone. Under the Pfizer Agreement, we were also entitled to receive reimbursement of up to $6.5 million for certain agreed-to research, manufacturing, and supply activities, as well as the transfer of all manufacturing-related know-how and materials, including all CMC documentation, data, and processes, to enable the manufacture of licensed compounds and products by Pfizer. We do not anticipate receiving reimbursement for any additional agreed-to services at this time.

Pfizer has also granted us a one-time option to obtain increased royalties if we exercise a buy up option within a certain amount of time from certain key early clinical data becoming available for the first licensed product. Following notice, we have a specified period to exercise the buy-up option to pay Pfizer a one-time $35.0 million fee (the "buy-up fee"). If we do not exercise the buy-up option and the option expires or is otherwise waived by us, we will recognize the revenue related to the license performance obligation as there are no remaining performance obligations. In the event we exercise the buy-up option and pay the buy-up fee, we are entitled to receive tiered royalties based on commercial sales levels from low teen to high teen percentages of net sales of licensed products. In connection with the closing of the XOMA Transaction, we expect to deliver to Pfizer a notice and waiver of the buy-up option.

Royalties are payable on a licensed product-by-licensed product and country-by-country basis beginning with the first commercial sale of such licensed product in such country of sale and expiring ten years after such sale, subject to specified and capped reductions for the market entry of biosimilar products, loss of patent coverage of licensed products, and for payments owed to third parties for additional rights necessary to commercialize licensed products in the territory.

*Collaboration Agreement with J&J*

In May 2020, we entered into a research collaboration and license agreement (the "J&J Agreement") with Johnson & Johnson ("J&J") (formerly Janssen Biotech, Inc.). As part of the J&J Agreement, we received a non-refundable upfront payment of $8.0 million, which we recognized on a straight-line basis over the two-year term of the research activities under the J&J Agreement. The straight-line method of recognition materially approximates the cost-to-cost method of revenue recognition. As of January 1, 2023, we had recorded the entirety of the $8.0 million upfront payment as revenue.

In December 2020, we achieved the first Research Milestone, as defined in the J&J Agreement, triggering a milestone payment of $1.0 million. In 2021, we achieved the second Research Milestone, triggering a milestone payment of $1.0 million. In May 2023, within the framework of the J&J Agreement, J&J selected a lead bispecific antibody utilizing the Gammabody platform for an undisclosed tumor associated antigen to progress into development, and we received a $2.5 million milestone payment. In October 2024, a milestone payment of $5.0 million from J&J was triggered under the terms of the J&J Agreement following filing with health authorities to start a Phase 1 clinical trial for JNJ-89853413. Each milestone payment was recorded as revenue when achieved, due to the variable consideration of the milestone payments no longer being constrained.

We are entitled to receive tiered royalties based on commercial sales levels from low to mid-single digit percentages of net sales of licensed products. Royalties are payable on a licensed product-by-licensed product and country-by-country basis beginning with the first commercial sale of such licensed product in such country of sale and expiring ten years after such sale, subject to specified and capped reductions for the market entry of biosimilar products, loss of patent coverage of licensed products, and for payments owed to third parties for additional rights necessary to commercialize licensed products in the territory.

#### Operating Expenses
Our primary categories of operating expenses are research and development expenses and general and administrative expenses.

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*Research and Development Expenses*

Research and development expenses consist primarily of the costs incurred in performing research and development activities and conducting preclinical studies and clinical trial activities. Our research and development expenses consist of:

● personnel-related expenses such as compensation and employee benefits for employees engaged in research and development;

● expenses incurred under agreements with contract manufacturing organizations ("CMOs"), contract research organizations ("CROs"), and consultants that conduct and support preclinical studies and clinical trial activities;

● expenses incurred in connection with internal research and development and research services agreements with third-parties;

● expenses including laboratory supplies and research materials, facility expenses, and depreciation of research and development fixed assets; and

● share-based compensation for employees engaged in research and development.

We expense research and development costs as incurred. We do not allocate employee-related costs, costs associated with our discovery efforts, laboratory supplies, depreciation, facility expenses or other indirect costs to specific product development programs because these costs are deployed across multiple programs, and as such, are not separately classified.

In connection with the XOMA transaction, we are in the process of discontinuing all clinical studies and nonclinical research and development activities.

*General and Administrative Expenses*

General and administrative expenses consist of costs incurred for operational expenses such as accounting, legal and insurance, and related activities. Our general and administrative expenses consist of:

&nbsp;&nbsp;&nbsp;&nbsp;● personnel-related expenses, such as compensation and employee benefits for employees engaged in general and administrative activities;

&nbsp;&nbsp;&nbsp;&nbsp;● professional and consultant fees for third-party consultants supporting audit, accounting, and finance compliance and financial consulting activities;

&nbsp;&nbsp;&nbsp;&nbsp;● expenses including facilities, insurance and related costs such as depreciation expenses and other corporate and operating expenses not included in research and development;

&nbsp;&nbsp;&nbsp;&nbsp;● in the 2025 periods, legal and accounting fees and other transaction expenses associated with the XOMA Transaction;

&nbsp;&nbsp;&nbsp;&nbsp;● share-based compensation for employees engaged in general and administrative activities; and

&nbsp;&nbsp;&nbsp;&nbsp;● expenses and legal costs related to the protection of our intellectual property.

General and administrative expenses are expensed as incurred.

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#### Gain on Extinguishment of Borrowings
In 2019, we applied for and received a $5.5 million Innovation Credit (the "Credit") from Rijksdienst voor Ondernemend Nederland ("RVO"). The Credit contributed to the development of LAVA-051, and we pledged certain assets of that project as a guarantee. In March 2025, we received notice from the RVO that the remaining loan balance of $5.2 million had been permanently waived. We recognized this non-cash gain on extinguishment within other income (expense), net in the condensed consolidated statement of operations and comprehensive loss during the nine months ended September 30, 2025.

#### Income Tax
We are subject to income taxes in the Netherlands, the United States, and Australia. Income tax expense of $0.1 million was recognized during both the three months ended September 30, 2025 and 2024, and income tax expense of $0.3 million was recognized during both the nine months ended September 30, 2025 and 2024 due to the profitable positions in the U.S. and Australia as a result of the cost plus intercompany renumeration in both jurisdictions.

We continue to be in a taxable loss position in the Netherlands and as such continue to maintain a full valuation allowance against all of our deferred tax assets in the jurisdiction. We have evaluated the positive and negative evidence involving our ability to realize the deferred tax assets and have concluded that it is more likely than not that we will not realize the benefits of our deferred tax assets. We reevaluate the positive and negative evidence at each reporting period.

On July 4, 2025, President Trump signed H.R. 1, the "One Big Beautiful Bill Act", into law which contains a broad range of tax reform provisions affecting businesses. In accordance with U.S. GAAP, we accounted for the tax effects of changes in tax law in the period of enactment, which was in the third quarter of calendar year 2025. We have analyzed the tax impacts of the law change and there is no material change to the financial statements.

#### Results of Operations

#### Comparison of the Three Months Ended September 30, 2025 and 2024
The following table summarizes our results of operations for the three months ended September 30, 2025 and 2024:

---

| | | | |
|:---|:---|:---|:---|
| | **Three Months Ended** | **Three Months Ended** | |
| | **September 30,** | **September 30,** | |
| <br>***(in thousands)*** | **2025** | **2024** | <br>**Change** |
| ***Revenue:*** |  |  |  |
| Revenue from contracts with customers | $— | $— | $— |
| &nbsp;&nbsp;Total revenue |  |  |  |
| ***Cost and expenses:*** |  |  |  |
| &nbsp;&nbsp;Research and development | (2239) | (8275) | (6036) |
| &nbsp;&nbsp;General and administrative | (5314) | (3065) | 2249 |
| Total cost and expenses | (7553) | (11340) | (3787) |
| Operating loss | (7553) | (11340) | (3787) |
| ***Other income (expense), net*** |  |  |  |
| &nbsp;&nbsp;Interest income | 537 | 957 | (420) |
| &nbsp;&nbsp;Interest expense |  | (131) | 131 |
| &nbsp;&nbsp;Foreign currency exchange loss, net | (166) | (1719) | 1553 |
| Total other income (expense), net | 371 | (893) | 1264 |
| Net loss before taxes | (7182) | (12233) | (5051) |
| &nbsp;&nbsp;Income tax expense | (6) | (96) | (90) |
| Net loss | $(7188) | $(12329) | $(5141) |

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*Research and Development Expenses*

Below are our research and development expenses for the three months ended September 30, 2025 and 2024:

---

| | | | |
|:---|:---|:---|:---|
| | **Three Months Ended**  | **Three Months Ended**  | |
| | **September 30,** | **September 30,** | |
| <br>***(in thousands)*** | **2025** | **2024** | <br>**Change** |
| Pre-clinical and clinical trial expenses | $1195 | $5718 | $(4523) |
| Personnel-related expenses | 760 | 1446 | (686) |
| Facilities and other research and development expenses | 127 | 550 | (423) |
| Share-based compensation expense | 107 | 246 | (139) |
| Research and development activities expenses | 50 | 315 | (265) |
|  | $**2239** | $**8275** | $**(6036)** |

---

Research and development expenses were $2.2 million for the three months ended September 30, 2025, compared to $8.3 million for the three months ended September 30, 2024. Pre-clinical and clinical trial expenses decreased by $4.5 million, primarily due to the discontinuation of the LAVA-1207 clinical trial in December 2024, offset by expenses accrued for the discontinuation of the LAVA-1266 clinical trial in August 2025. Personnel-related expenses decreased by $0.7 million primarily due to a reduction in headcount in 2024 offset by the accrual of severance payments related to the July 2025 restructuring activities. Facilities and other research and development expenses decreased by $0.4 million due to the termination of our lease arrangements in Utrecht, Netherlands and Den Bosch, Netherlands. Share-based compensation expense decreased by $0.1 million due to fewer options being issued in 2025 as compared to 2024 and a reduction in our overall share price. Research and development activities expenses decreased by $0.3 million primarily due to decreased third-party research project expenses in the three months ended September 30, 2025 as compared to the same period in 2024. We expect our research and development expenses to continue to decrease as we discontinue our clinical and nonclinical programs in light of the XOMA Transaction.

*General and Administrative Expenses*

Below are our general and administrative expenses for the three months ended September 30, 2025 and 2024:

---

| | | | |
|:---|:---|:---|:---|
| | **Three Months Ended**  | **Three Months Ended**  | |
| | **September 30,** | **September 30,** | |
| <br>***(in thousands)*** | **2025** | **2024** | <br>**Change** |
| Professional and consultant fees | $4081 | $796 | $3285 |
| Insurance, facilities, fees and other related costs | 659 | 597 | 62 |
| Personnel-related expenses | 287 | 977 | (690) |
| Share-based compensation expense | 287 | 475 | (188) |
| Patent-related costs |  | 220 | (220) |
|  | $**5314** | $**3065** | $**2249** |

---

General and administrative expenses were $5.3 million for the three months ended September 30, 2025, compared to $3.1 million for the three months ended September 30, 2024. Professional and consultant fees inceased by $3.3 million primarily due to legal and professional fees associated with the XOMA Transaction incurred during the three months ended September 30, 2025. Personnel-related expenses decreased by $0.7 million primarily due to the reduction in headcount related to the May 2025 restructuring activities. Share-based compensation expense decreased by $0.2 million due to fewer options being issued in 2025 as compared to 2024 and a reduction in our overall share price. Patent-related costs decreased by $0.2 million due to a reduction in the number of patent filings we made. Our general and administrative expenses may continue to increase in the short term as we pursue the closing of the XOMA Transaction.

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*Other income (expense), net*

Other (expense) income, net was $0.4 million for the three months ended September 30, 2025, compared to $(0.9) million for the three months ended September 30, 2024. The increase of $1.3 million is primarily due a period over period decrease of $1.6 million in foreign exchange loss, net due to the impact of the fluctuation of the USD currency rate compared to the Euro. Interest income decreased by $0.4 million and interest expense decreased by $0.1 million, respectively, for the three months ended September 30, 2025 compared to the three months ended September 30, 2024. The decrease in interest income was due to less cash held in money market accounts, while the decrease in interest expense was due to the forgiveness of the RVO credit balance and related interest being waived in March 2025.

#### Comparison of the Nine Months Ended September 30, 2025 and 2024
The following table summarizes our results of operations for the nine months ended September 30, 2025 and 2024:

---

| | | | |
|:---|:---|:---|:---|
| | **Nine Months Ended** | **Nine Months Ended** | |
| | **September 30,** | **September 30,** | |
| <br>***(in thousands)*** | **2025** | **2024** | <br>**Change** |
| ***Revenue:*** |  |  |  |
| Revenue from contracts with customers | $— | $6992 | $(6992) |
| &nbsp;&nbsp;Total revenue |  | 6992 | (6992) |
| ***Cost and expenses:*** |  |  |  |
| &nbsp;&nbsp;Research and development | (11134) | (19881) | (8747) |
| &nbsp;&nbsp;General and administrative | (11296) | (9881) | 1415 |
| Total cost and expenses | (22430) | (29762) | (7332) |
| Operating loss | (22430) | (22770) | (340) |
| ***Other income (expense), net*** |  |  |  |
| &nbsp;&nbsp;Interest income | 1857 | 2895 | (1038) |
| &nbsp;&nbsp;Interest expense | (129) | (390) | 261 |
| &nbsp;&nbsp;Foreign currency exchange loss, net | (3504) | (722) | (2782) |
| &nbsp;&nbsp;Gain on extinguishment of borrowings | 5203 |  | 5203 |
| Total other income, net | 3427 | 1783 | 1644 |
| Net loss before taxes | (19003) | (20987) | (1984) |
| &nbsp;&nbsp;Income tax expense | (303) | (250) | 53 |
| Net loss | $(19306) | $(21237) | $(1931) |

---

*Revenue from Contracts with Customers*

Our revenue from contracts with customers was $7.0 million for the nine months ended September 30, 2024.

In connection with the Pfizer Agreement, we recognized $7.0 million in revenue in the nine months ended September 30, 2024 related to the achievement by Pfizer of a clinical development milestone for PF-08046052, less than $0.1 million for agreed-to reimbursement activities, and less than $0.1 million for other services in connection with the Pfizer Agreement. We did not recognize any revenue under the Pfizer Agreement in the nine months ended September 30, 2025.

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*Research and Development Expenses*

Below are our research and development expenses for the nine months ended September 30, 2025 and 2024:

---

| | | | |
|:---|:---|:---|:---|
| | **Nine Months Ended** | **Nine Months Ended** | |
| | **September 30,** | **September 30,** | |
| <br>***(in thousands)*** | **2025** | **2024** | <br>**Change** |
| Pre-clinical and clinical trial expenses | $5230 | $12817 | $(7587) |
| Personnel-related expenses | 3404 | 3971 | (567) |
| Facilities and other research and development expenses | 1213 | 1192 | 21 |
| Research and development activities expenses | 785 | 939 | (154) |
| Share-based compensation expense | 502 | 962 | (460) |
|  | $**11134** | $**19881** | $**(8747)** |

---

Research and development expenses were $11.1 million for the nine months ended September 30, 2025, compared to $19.9 million for the nine months ended September 30, 2024. Pre-clinical and clinical trial expenses decreased by $7.6 million, primarily due to the discontinuations of the LAVA-1207 clinical trial in December 2024 and the LAVA-1266 clinical trial in August 2025. Personnel-related expenses decreased by $0.6 million due to a reduction in salaries and wages resulting from the discontinuation of the LAVA-1207 and LAVA-1266 clinical trials, offset by severance costs associated with the discontinuation of the trials. Research and development activities expenses decreased by $0.2 million primarily due to a decrease in third-party research project expenses in the nine months ended September 30, 2025 as compared to the same period in 2024. Share-based compensation expense decreased by $0.5 million due to fewer options issued in the nine months ended September 30, 2025 as compared to the same period in 2024 and a reduction in our overall share price. We expect our research and development expenses to continue to decrease as we discontinue our clinical and nonclinical programs in light of the XOMA Transaction.

*General and Administrative Expenses*

Below are our general and administrative expenses for the nine months ended September 30, 2025 and 2024:

---

| | | | |
|:---|:---|:---|:---|
| | **Nine Months Ended** | **Nine Months Ended** | |
| | **September 30,** | **September 30,** | |
| <br>***(in thousands)*** | **2025** | **2024** | <br>**Change** |
| Professional and consultant fees | $5964 | $2376 | $3588 |
| Personnel-related expenses | 2529 | 2937 | (408) |
| Insurance, facilities, fees and other related costs | 1778 | 1951 | (173) |
| Share-based compensation expense | 872 | 1674 | (802) |
| Patent-related costs | 153 | 943 | (790) |
|  | $**11296** | $**9881** | $**1415** |

---

General and administrative expenses were $11.3 million for the nine months ended September 30, 2025, compared to $9.9 million for the nine months ended September 30, 2024. Professional and consultant fees inceased by $3.6 million primarily due legal and professional fees associated with our announced and ongoing transaction with XOMA incurred during the nine months ended September 30, 2025. Personnel-related expenses decreased $0.4 million primarily due to the reduction in headcount related to the restructuring activities in February and May 2025, offset by salary increases for employees and the accrual of severance payments related to the restructuring activities. Insurance, facilities, fees and other related costs decreased by $0.2 million primarily due to a reduction in directors and officers insurance premiums as well as reduced office lease costs. Share-based compensation expense decreased by $0.8 million due to fewer options issued in the nine months ended September 30, 2025 as compared to the same period in 2024 and a reduction in our overall share price. Patent-related costs decreased by $0.8

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million due to a reduction in the number of patent filings we made in 2025 as compared to the same period in the prior year. Our general and administrative expenses may continue to increase in the short term as we pursue the closing of the XOMA Transaction.

*Other income (expense), net*

Other income (expense), net was $3.4 million for the nine months ended September 30, 2025, compared to $1.8 million for the nine months ended September 30, 2024. The increase of $1.6 million is primarily due a $5.2 million gain on extinguishment of borrowings due to the RVO credit balance being waived in March 2025, offset by a period over period change of $2.8 million in foreign exchange loss, net due to the impact of the fluctuation of the USD compared to the Euro and an interest income decrease by $1.0 million for the nine months ended September 30, 2025 compared to the nine months ended September 30, 2024.

#### Liquidity and Capital Resources

#### Sources of Liquidity
We have historically funded our operations primarily through issuance of preference shares prior to our initial public offering ("IPO"), from the sale of common shares in our IPO, and more recently, through research and licensing revenue and receipt of milestone payments under our collaboration agreements. Our expenditures are primarily related to research and development activities and general administrative activities to support business operations.

In 2019, we received a $5.5 million Innovation Credit from Rijksdienst voor Ondernemend Nederland (RVO) for the LAVA-051 program. Borrowings under the Innovation Credit, which bore interest at 10.0%, were received in quarterly installments. In March 2025, we received notice from the RVO that the remaining loan balance of $5.2 million had been permanently waived. We recognized this non-cash gain on extinguishment within other income (expense), net in the condensed consolidated statement of operations and comprehensive loss during the nine months ended September 30, 2025.

Under the Pfizer Agreement, we received a nonrefundable up-front payment of $50.0 million in October 2022 and a clinical milestone payment of $7.0 million in March 2024. Additionally, we were entitled to reimbursement of up to $6.5 million for certain agreed-to research, manufacturing, and supply activities under the Pfizer Agreement, and received an aggregate amount of $6.4 million. We do not anticipate receiving reimbursement for any additional agreed-to services at this time. Under the J&J Agreement, we have recognized an aggregate amount of $17.5 million of revenue to date, including a nonrefundable up-front payment of $8.0 million in May 2020 and aggregate clinical milestone payments of $9.5 million to date.

Cash and cash equivalents and short-term investments are financial instruments that potentially subject us to concentrations of credit risk. As of September 30, 2025 and December 31, 2024, cash consists of cash deposited with four financial institutions and account balances in excess of the federally insured limits. Management believes that we are not exposed to significant credit risk due to the financial strength of these financial institutions.

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#### Contractual Obligations and Commitments
During the three and nine months ended September 30, 2025, there were no material changes to our contractual obligations and commitments from those described in our Annual Report on Form 10-K for the year ended December 31, 2024, which was filed with the SEC on March 28, 2025.

#### Funding Requirements
We had cash and cash equivalents of $49.7 million as of September 30, 2025, which we believe will be sufficient to fund our planned expenditures and meet our obligations for at least the next twelve months from the issuance date of the condensed consolidated financial statements. Because of the numerous risks and uncertainties associated with the status of our company and the XOMA Transaction, we are unable to estimate the exact amount of our operating capital requirements. The amount and timing of our future funding requirements will depend on many factors, including, but not limited to:

● the amount of time it takes to consummate the XOMA Transaction, including any potential extensions of the offer period and the timing and outcome of our EGM, and whether the XOMA Transaction is completed at all;

● the amount and cost of legal and professional services required to consummate the XOMA Transaction, including fees related to the engagement of advisors; and

● our need to continue to operate as a public company.

#### Cash Flows

#### Comparison of the Nine Months Ended September 30, 2025 and 2024
The following table summarizes our cash flows for each of the periods presented:

---

| | | | |
|:---|:---|:---|:---|
| | **Nine Months Ended** | **Nine Months Ended** | |
| | **September 30,**  | **September 30,**  | |
| <br>***(in thousands)*** | **2025** | **2024** | <br>**Change** |
| Net cash used in operating activities | $(30262) | $(19050) | $(11212) |
| Net cash provided by investing activities | 40364 | 1499 | 38865 |
| Net cash provided by financing activities |  | 25 | (25) |
| Net increase (decrease) in cash and cash equivalents | $**10102** | $**(17526)** | $**27628** |

---

*Operating Activities*

During the nine months ended September 30, 2025, $30.3 million of cash was used in operating activities, primarily resulting from our net loss of $19.3 million, net non-cash add-backs of $2.1 million, which included a gain on extinguishment of borrowings of $5.2 million, and net cash used by changes in our operating assets and liabilities of $8.8 million. Net cash used by changes in our operating assets and liabilities for the nine months ended September 30, 2025 consisted primarily of a decrease in prepaid expenses and other current assets of $0.7 million, a decrease in accrued expenses and other current liabilities of $8.2 million, and a decrease in accounts payable of $1.3 million.

During the nine months ended September 30, 2024, $19.1 million of cash was used in operating activities, primarily resulting from our net loss of $21.2 million, net non-cash charges of $2.0 million, and net cash used by changes in our operating assets and liabilities of $0.2 million. Net cash used by changes in our operating assets and liabilities for the nine months ended September 30, 2024 consisted primarily of a decrease in prepaid expenses and other current assets of $0.4 million, a decrease in accounts payable of $2.7 million, and an increase in accrued expenses and other current liabilities of $2.6 million.

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*Investing Activities*

Net cash provided by investing activities for the nine months ended September 30, 2025 was $40.4 million compared to net cash provided by investing activities of $1.5 million for the nine months ended September 30, 2024. During the nine months ended September 30, 2025, we received $40.1 million from the maturities of investments and $0.3 million from proceeds from the sale of property and equipment. During the nine months ended September 30, 2024, we received $77.0 million from the maturities of investments, offset by purchases of investments of $75.6 million.

*Financing Activities*

Net cash provided by financing activities for the nine months ended September 30, 2025 and 2024 was $0.0 million and less than $0.1 million, respectively. The net cash provided by financing activities for the nine months ended September 30, 2024 was due to proceeds from option exercises.

#### Critical Accounting Policies and Estimates
Our financial statements are prepared in accordance with generally accepted accounting principles in the United States. The preparation of our financial statements and related disclosures requires us to make estimates, assumptions and judgments that affect the reported amount of assets, liabilities, revenue, costs and expenses, and related disclosures. Our critical accounting policies are described under the heading "Management's Discussion and Analysis of Financial Condition and Results of Operations—Critical Accounting Policies and Estimates" in our Annual Report on Form 10-K. If actual results or events differ materially from the estimates, judgments and assumptions used by us in applying these policies, our reported financial condition and results of operations could be materially affected. There have been no significant changes to our critical accounting policies from those described in our Annual Report on Form 10-K.

#### Recently Adopted Accounting Pronouncements
A description of recently adopted accounting pronouncements that may potentially impact our financial position, results of operations and cash flows is disclosed in Note 2 to our unaudited condensed consolidated financial statements appearing elsewhere in this Quarterly Report.

#### Item 3. Quantitative and Qualitative Disclosures About Market Risk
We are a smaller reporting company as defined by Item 10 of Regulation S-K and are not required to provide the information otherwise required under this item.

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#### Item 4. Controls and Procedures

#### Evaluation of Disclosure Controls and Procedures
Our management, with the participation of our Chief Executive Officer and our Chief Financial Officer, have evaluated the effectiveness of our disclosure controls and procedures (as defined in Rule 13a-15(e) and 15d-15(e) of the Exchange Act of 1934, as amended) as of the end of the period covered by this Quarterly Report. Based on that evaluation, management, including our Chief Executive Officer and Chief Financial Officer, have concluded that as of September 30, 2025, our disclosure controls and procedures were effective at a reasonable assurance level.

Our disclosure controls and procedures are designed to provide reasonable assurance that information required to be disclosed by us in reports that we file or submit under the Exchange Act is (i) recorded, processed, summarized and reported within the time periods specified in the SEC's rules and forms and (ii) accumulated and communicated to management, including our Chief Executive Officer and Chief Financial Officer, as appropriate, to allow timely discussions regarding required disclosure. We believe that a control system, no matter how well designed and operated, cannot provide absolute assurance that the objectives of the control system are met, and no evaluation of controls can provide absolute assurance that all control issues and instances of fraud, if any, within a company have been detected. As such, management necessarily applies its judgment in evaluating the cost-benefit relationship of possible controls and procedures.

#### Changes in Internal Control Over Financial Reporting
There were no changes in our internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) under the Exchange Act) during the quarter ended September 30, 2025 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

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#### PART II. OTHER INFORMATION

#### Item 1. Legal Proceedings
From time to time, we may become involved in legal proceedings arising in the ordinary course of our business. We are not currently subject to any material legal proceedings.

#### Item 1A. Risk Factors
Investing in our common shares involves a high degree of risk. In addition to the other information set forth in this Quarterly Report on Form 10-Q, you should carefully consider the risks described in the Annual Report, including the disclosure therein under Part I, Item 1A, "Risk Factors," before deciding whether to invest in our common shares. These are not the only risks facing our business. Other risks and uncertainties that we are not currently aware of or that we currently consider immaterial also may materially adversely affect our business, financial condition and future results. Risks we have identified but currently consider immaterial could still also materially adversely affect our business, financial condition and future results of operations if our assumptions about those risks are incorrect or if circumstances change.

There were no material changes during the period covered in this Quarterly Report to the risk factors previously disclosed in Part I, Item 1A of the Annual Report, except as follows:

**Risks Related to the Proposed Transactions with XOMA**

***The XOMA Transaction is subject to a number of conditions beyond our control. Failure to complete proposed transactions within the expected time frame, or at all, could have a material adverse effect on our business, operating results, financial condition and our share price.***

On August 3, 2025, we entered into the Purchase Agreement with XOMA, pursuant to which, and upon the terms and subject to the conditions of, XOMA has commenced a tender offer to purchase all of our outstanding common shares. Pursuant to the Purchase Agreement and the Amendment, XOMA's obligation to accept our common shares tendered in the Offer is subject to conditions, including: (i) that the number of common shares validly tendered and not validly withdrawn, represents at least 80% (which may be lowered to 75% in certain cases) of our issued and outstanding share capital immediately prior to the expiration of the Offer (such condition, the "Minimum Condition"); (ii) our Closing Net Cash (as defined in and determined in accordance with the Purchase Agreement) will be at least $24.5 million as of the expiration of the Offer (the "Closing Net Cash Condition"); (iii) the accuracy of our representations and warranties contained in the Purchase Agreement, including that, since the date of the Purchase Agreement, there shall not have occurred any Company Material Adverse Effect (as defined in the Purchase Agreement), (iv) our performance in all material respects of its obligations under the Purchase Agreement, (v) the adoption of certain resolutions by our shareholders at an extraordinary general meeting and (vi) the other conditions set forth in the Purchase Agreement. The obligations of XOMA to consummate the proposed transactions under the Purchase Agreement are not subject to a financing condition.

We cannot predict whether or when these conditions will be satisfied. If one or more of these conditions are not satisfied, and as a result, we do not complete the proposed transactions, we would remain liable for significant transaction costs, and the focus of our management would have been diverted from seeking other potential strategic opportunities, in each case without realizing any benefits of the proposed transactions. There is no guarantee that we will achieve the Minimum Condition during the current Offer period which expires one minute after 11:59 p.m. ET on November 12, 2025, or during any extension of the Offer period. Additional extensions of the Offer period will result in continued depletion of our cash and cash equivalents and could compromise our ability to meet the Closing Net Cash Condition. We also must obtain shareholder approval of the proposals at our reconvened EGM, which requires us to achieve both quorum and the requisite votes to pass each of the proposals. If we need to adjourn or reconvene

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the EGM to achieve sufficient votes in favor of the proposals, we will need to expend further resources and the closing of the XOMA Transaction could be delayed. Sales of shares by our larger shareholders during the Offer period may also make it more difficult to satisfy the Minimum Condition and achieve the requisite shareholder approval.

Certain costs associated with the XOMA Transaction have already been incurred or may be payable even if the the transaction is not consummated. Finally, any disruptions to our business resulting from the announcement and pendency of the XOMA Transaction, including any adverse changes in our relationships with our partners, suppliers and employees, could continue or accelerate in the event that we fail to consummate the XOMA Transaction.

Our share price may also fluctuate significantly based on announcements by XOMA, other third parties, or us regarding the proposed transactions or based on market perceptions of the likelihood of the satisfaction of the Minimum Condition or other conditions to the consummation of the proposed transactions. Such announcements may lead to perceptions in the market that the proposed transactions may not be completed, which could cause our share price to fluctuate or decline. Other factors outside of our control, such as a governmental entity enacting a legal restraint or prohibition that prevents or prohibits the proposed transactions, could cause us not to satisfy the closing condition relating to the absence of legal restraints and thus the XOMA Transaction would not be consummated. Further, unforeseen and unexpected expenses could cause our net cash to be below the applicable threshold thus causing us to fail to satisfy the Closing Net Cash Condition.

If we do not consummate the XOMA Transaction, the price of our common shares may decline significantly from the current market price, which may reflect a market assumption that the XOMA Transaction will be consummated. Any of these events could have a material adverse effect on our business, operating results and financial condition and could cause a decline in the price of our common shares.

***Our shareholders may not receive any payment on the CVR and the CVR may expire valueless.***

If the XOMA Transaction is completed, the holders of our common shares and in the money Company Options will be entitled to receive one CVR per share (or underlying share, as the case may be), representing the right to receive, subject to the terms and conditions of the CVR Agreement, contingent cash payments calculated as follows: (i) 100% of the amount by which our Closing Net Cash as adjusted for any Permitted Deductions (as defined in the CVR Agreement) made within ninety (90) days following the date on which the closing occurs (the "Closing Date"), exceeds Closing Net Cash as finally determined pursuant to the Purchase Agreement; (ii) (A) 100% of the Net Proceeds (as defined in the CVR Agreement), if any, from any disposition by us, of all or any part of the rights, intellectual property and other assets related to our LAVA-1266 program entered into prior to the Closing or (B) 75% of the Net Proceeds, if any, of such dispositions by XOMA and its affiliates (including us after the Closing) from the Closing until 10 years after the Closing (the "Expiration Date"); (iii) 75% of the Net Proceeds, if any, due to or received by XOMA or any of its affiliates, including us (after the closing), in respect of our collaborations with Pfizer and J&J after the Closing until the Expiration Date; and (iv) 100% of an amount equal to $6,330,000, minus any tax liabilities or other costs or expenses incurred in connection with or related to the Tax Reserve Matter (as defined in the CVR Agreement), for the period beginning at the Closing Date and ending no later than sixty (60) days following the Tax Reserve Confirmation Date (as defined in the CVR Agreement). In the event that no CVR Proceeds (as defined in and determined in accordance with the CVR Agreement) become payable prior to the Expiration Date, holders of the CVRs will not receive any payment pursuant to the CVR Agreement. The CVRs will not be transferable, except in the limited circumstances specified in the CVR Agreement, will not have any voting or dividend rights, and will not represent any equity or ownership interest in us or any of our affiliates, and interest will not accrue on any amounts potentially payable on the CVRs. Accordingly, the right of any of our shareholders to receive any future payment on or derive any value from the CVRs will be contingent solely upon the occurrence of a disposition or the receipt of payments under our Pfizer and J&J collaborations and the resolution of the Tax Reserve Matter, as outlined above, and if no such dispositions or payments are achievedfor any reason, or if the Tax Reserve Matter is resolved in a way that results in no proceeds after

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payment of tax liabilities and other costs or expenses, within the time periods specified in the CVR Agreement, no payments will be made under the CVRs, and the CVRs will expire valueless.

***The Purchase Agreement contains provisions that could discourage a potential competing acquirer.***

The Purchase Agreement provides that, upon the terms and subject to the conditions thereof, we and our representatives cannot directly or indirectly solicit, initiate, encourage or knowingly facilitate discussions with third parties regarding other proposals to acquire or combine with us and we are subject to restrictions on our ability to respond to any such proposal. In the event that we receive an acquisition proposal from a third party, we must notify XOMA of such proposal and negotiate in good faith with XOMA prior to terminating the Purchase Agreement or effecting a change in the recommendation of our board of directors to our shareholders with respect to the XOMA Transaction. The Purchase Agreement also contains certain termination rights for XOMA and us and further provides that, upon termination of the Purchase Agreement under specified circumstances, including certain terminations in connection with an alternative business combination transaction as permitted by the terms of the Purchase Agreement, we will be required to pay XOMA a termination fee of $750,000. These provisions could discourage a potential third-party acquirer that might have an interest in acquiring all or a significant portion of us from considering or proposing that acquisition, even if it were prepared to pay consideration with a higher per share cash or market value than the market value proposed to be received or realized in the XOMA Transaction. These provisions also might result in a potential third-party acquirer proposing to pay a lower price to our shareholders than it might otherwise have proposed to pay due to the added expense of the termination fee that may become payable in certain circumstances. If the Purchase Agreement is terminated and we decide to seek another business combination, we may not be able to negotiate a transaction with another party on terms comparable to, or better than, the terms of the XOMA Transaction.

***Shareholder or other litigation could prevent or delay the consummation of the XOMA Transaction or otherwise negatively impact our business, operating results and financial condition.***

Complaints or lawsuits may in the future be filed against us, our board of directors, XOMA, any of XOMA's boards of directors and/or others in connection with the XOMA Transaction. The outcome of litigation is uncertain, including the amount of costs associated with defending these claims or any other liabilities that may be incurred in connection with the litigation of these claims, and we may not be successful in defending against any such future claims.

We may incur additional costs in connection with the defense or settlement of any future shareholder or other litigation (including creditor opposition filed under Dutch law) in connection with the XOMA Transaction. Further, any such future litigation (including creditor opposition) could cause a delay in completion of the XOMA Transaction or may adversely affect our ability to complete the proposed transactions and may impact our ability to meet the Closing Net Cash Condition. We could incur significant costs in connection with any such litigation (including creditor opposition), including costs associated with the indemnification of our directors and executive officers, and lawsuits may divert the attention of our management and employees from our day-to-day business which could affect our operations and otherwise adversely affect us financially.

***The announcement and pendency of the XOMA Transaction could adversely affect our business, financial results and/or operations.***

Employee retention may be particularly challenging while the XOMA Transaction is pending because employees may experience uncertainty about their roles following the XOMA Transaction. A substantial amount of our management's and employees' attention is being directed toward the completion of the XOMA Transaction and thus is being diverted from our day-to-day operations. The adverse effects of the pendency of the XOMA Transaction could be exacerbated by any delays in the completion of the transaction or termination of the Purchase Agreement. In addition, our executive officers and directors

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may have interests in the XOMA Transaction that are different from, or are in addition to, those of our shareholders generally. These interests include without limitation the following: the receipt of transaction bonuses payable to executive officers under certain transaction bonus letters; and the potential receipt of severance payments and benefits by executive officers under their respective employment letters.

***While the XOMA Transaction is pending, we are subject to business uncertainties and contractual restrictions that could disrupt our business, and the XOMA Transaction may impair our ability to retain qualified employees or retain and maintain relationships with our other business partners.***

Whether or not the XOMA Transaction is consummated, the XOMA Transaction may disrupt our current plans and operations, which could have an adverse effect on our business and financial results. The pendency of the XOMA Transaction may also divert management's attention and our resources from ongoing business and operations and our employees. Other key personnel may have uncertainties about the effect of the XOMA Transaction, and the uncertainties may impact our ability to retain key personnel while the XOMA Transaction is pending or in the event that we are unable to consummate the XOMA Transaction within the expected time frames or at all. If key personnel depart because of such uncertainties, our business and results of operations may be adversely affected.

In addition, pending consummation of the XOMA Transaction, the Purchase Agreement generally requires us to operate in the ordinary course of business consistent with past practice and our intent to wind down our activities, and restricts us from taking certain actions with respect to our business and financial affairs without XOMA's consent. Such restrictions will be in place until either the proposed transactions are consummated or the Purchase Agreement is terminated. These restrictions could restrict our ability to, or prevent us from, pursuing attractive business opportunities (if any) that arise prior to the consummation of the XOMA Transaction. For these and other reasons, the pendency of the proposed transactions could adversely affect our business, operating results and financial condition.

***We have incurred, and will continue to incur, direct and indirect costs as a result of the XOMA Transaction.***

We have incurred, and will continue to incur, significant costs and expenses, including fees for professional services and other transaction costs, in connection with the proposed transactions, including costs that we may not currently expect. We must pay substantially all of these costs and expenses whether or not the transaction is completed. If the Purchase Agreement is terminated under certain circumstances specified in the Purchase Agreement, including in connection with the Company's entry into an agreement with respect to a Superior Proposal, we will be required to pay XOMA a termination fee of approximately $750,000. There are a number of factors beyond our control that could affect the total amount or the timing of these costs and expenses, including the extension of the Offer period or the need to adjourn or reconvene our EGM.

***If the XOMA Transaction is not consummated, our board of directors may decide to pursue a dissolution and liquidation. In such an event, the amount of cash available for distribution to our shareholders will depend heavily on the timing of such liquidation as well as the amount of cash that will need to be reserved for commitments and contingent liabilities.***

There can be no assurance that the XOMA Transaction will be consummated. If the XOMA Transaction is not consummated, the board of directors may decide to pursue a dissolution and liquidation of the Company. In such an event, the amount of cash available for distribution to our shareholders will depend heavily on the timing of such decision, as the amount of cash available for distribution will decline over time as we continue to fund our operations and as we expend resources pursuing the XOMA Transaction. In addition, if our board of directors were to approve and recommend, and our shareholders were to approve, a dissolution and liquidation, we would be required under Dutch corporate law to pay our outstanding obligations, as well as to make reasonable provision for contingent and unknown obligations, prior to making any distributions in liquidation to our shareholders, which distributions may also be subject to applicable taxes. As a result of this requirement, a portion of our assets may need to be reserved pending the resolution of such obligations and the timing of any such resolution would be uncertain.

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In addition, we may be subject to litigation (including creditor opposition), or other claims related to a dissolution and liquidation. If a dissolution and liquidation were pursued, our board of directors, in consultation with our advisors, would need to evaluate these matters and make a determination about a reasonable amount to reserve. Accordingly, holders of our common shares could lose all or a significant portion of their investment in the event of a liquidation, dissolution or winding up.

#### Item 2. Unregistered Sales of Equity Securities and Use of Proceeds
None.

#### Item 3. Defaults Upon Senior Securities
None.

#### Item 4. Mine Safety Disclosures
Not applicable.

#### Item 5. Other Information
*Adoption, Modification and Termination of Rule 10b5-1 Plans and Certain Other Trading Arrangements*

During the fiscal quarter ended September 30, 2025, none of our directors or officers (as defined in Rule 16a-1(f) under the Exchange Act) adopted, modified or terminated a "Rule 10b5-1 trading arrangement" or a "non-Rule 10b5-1 trading arrangement" (as each term is defined in Item 408 of Regulation S-K).

*Termination of Named Executive Officer*

In connection with the Restructuring Plan, on October 6, 2025 the Company and Charles Morris, M.D., Ph.D. agreed on Dr. Morris' separation from his role as Chief Medical Officer of the Company. The material terms of Dr. Morris' separation are stated in his employment agreement, a copy of which is filed as Exhibit 10.13 to the Company's most recent Annual Report on Form 10-K and is incorporated by reference herein.

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**Item 6. Exhibits**

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | | **Incorporation by Reference** | **Incorporation by Reference** | **Incorporation by Reference** | **Incorporation by Reference** |
| <br>**ExhibitNumber** | <br>**Description** | **Schedule/Form** | **File Number** | **Exhibit** | **Filling Date** |
| 2.1+ | [Share Purchase Agreement, dated August 3, 2025, by and among XOMA Royalty Corporation and LAVA Therapeutics N.V.](https://www.sec.gov/Archives/edgar/data/1840748/000110465925073374/tm2522230d1_ex2-1.htm)<br>| 8-K | 000-40241 | 2.1 | August 4, 2025 |
| 2.2  | [Amendement to Share Purchase Agreement, dated October 17, 2025, by and among XOMA Royalty Corporation and LAVA Therapeutics N.V.](https://www.sec.gov/Archives/edgar/data/1840748/000110465925100317/tm2528774d1_ex2-1.htm)<br>| 8-K | 000-40241 | 2.1 | October 17, 2025 |
| 3.1 | [Amended and Restated English translation of Articles of Association of LAVA Therapeutics N.V.](https://www.sec.gov/Archives/edgar/data/1840748/000155837025003988/lvtx-20241231xex3d1.htm) | 10-K | 000-40241 | 3.1 | March 28, 2025 |
| 31.1\* | [Certification of Principal Executive Officer Pursuant to Rule 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002](lvtx-20250930xex31d1.htm) |  |  |  |  |
| 31.2\* | [Certification of Principal Financial Officer Pursuant to Rule 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.](lvtx-20250930xex31d2.htm) |  |  |  |  |
| 32.1\*† | [Certification of Principal Executive Officer Pursuant to 18 U.S.C. Section1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.](lvtx-20250930xex32d1.htm) |  |  |  |  |

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| | |
|:---|:---|
| 32.2\*† | [Certification of Principal Financial Officer Pursuant to 18 U.S.C. Section1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.](lvtx-20250930xex32d2.htm) |
| 101.INS\* | Inline XBRL Instance Document. |
| 101.SCH\* | Inline XBRL Taxonomy Extension Schema Document. |
| 101.CAL\* | Inline XBRL Taxonomy Calculation Linkbase Document. |
| 101.DEF\* | Inline XBRL Taxonomy Extension Definition Linkbase Document. |
| 101.LAB\* | Inline XBRL Taxonomy Label Linkbase Document. |
| 101.PRE\* | Inline XBRL Taxonomy Presentation Linkbase Document. |
| 104 | Cover Page Interactive Data File (the cover page iXBRL tags are embedded within the Inline XBRL document) |

---

\* Filed or furnished herewith

+ Certain schedules and annexes have been omitted pursuant to Item 601(a)(5) of Regulation S-K. The Company hereby undertakes to furnish supplementally copies of any of the omitted schedules and annexes upon request by the SEC; provided, however, that the Company may request confidential treatment pursuant to Rule 24b-2 of the Exchange Act for any annexes or schedules so furnished.

† These certifications are being furnished solely to accompany this Quarterly Report pursuant to 18 U.S.C. Section 1350, and are not being filed for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, and are not to be incorporated by reference into any filing of the Registrant, whether made before or after the date hereof, regardless of any general incorporation language in such filing.

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#### SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

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| | | |
|:---|:---|:---|
| **LAVA Therapeutics N.V.**<br>|  |  |
|  | **LAVA Therapeutics N.V.** | **LAVA Therapeutics N.V.** |
| Date: November 6, 2025 | By: | /s/ Stephen Hurly |
|  |  | **Stephen Hurly** |
|  |  | President and Chief Executive Officer<br>(*Principal Executive Officer*)<br>|
| Date: November 6, 2025 | By: | /s/ Fred Powell |
|  |  | **Fred Powell** |
|  |  | Chief Financial Officer<br>(*Principal Financial Officer and Principal Accounting Officer*) |

---

## Exhibit 31.1

**EXHIBIT 31.1**

**CERTIFICATION OF THE PRINCIPAL EXECUTIVE OFFICER**

**PURSUANT TO EXCHANGE ACT RULE 13A-14(A) OR 15D-14(A) AS ADOPTED**

**PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002**

I, Stephen Hurly, certify that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. I have reviewed this quarterly report on Form 10-Q of LAVA Therapeutics N.V.;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the company as of, and for, the periods presented in this report;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4. The company's other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the company and have:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the company, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Evaluated the effectiveness of the company's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) Disclosed in this report any change in the company's internal control over financial reporting that occurred during the company's most recent fiscal quarter (the company's fourth quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the company's internal control over financial reporting; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5. The company's other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the company's auditors and the audit committee of the company's board of directors (or persons performing the equivalent functions):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the company's ability to record, process, summarize and report financial information; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the company's internal control over financial reporting.

Date: November 6, 2025

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| | |
|:---|:---|
| By: | /s/ Stephen Hurly |
| Name: | Stephen Hurly |
| Title: | Chief Executive Officer (Principal Executive Officer) |

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## Exhibit 31.2

**EXHIBIT 31.2**

**CERTIFICATION OF THE PRINCIPAL FINANCIAL OFFICER**

**PURSUANT TO EXCHANGE ACT RULE 13A-14(A) OR 15D-14(A) AS ADOPTED**

**PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002**

I, Fred Powell, certify that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. I have reviewed this quarterly report on Form 10-Q of LAVA Therapeutics N.V.;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the company as of, and for, the periods presented in this report;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4. The company's other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the company and have:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the company, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Evaluated the effectiveness of the company's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) Disclosed in this report any change in the company's internal control over financial reporting that occurred during the company's most recent fiscal quarter (the company's fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the company's internal control over financial reporting; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5. The company's other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the company's auditors and the audit committee of the company's board of directors (or persons performing the equivalent functions):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the company's ability to record, process, summarize and report financial information; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the company's internal control over financial reporting.

Date: November 6, 2025

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| | |
|:---|:---|
| By: | /s/ Fred Powell |
| Name: | Fred Powell |
| Title: | Chief Financial Officer (Principal Financial Officer) |

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## Exhibit 32.1

**EXHIBIT 32.1**

**Certification by the Principal Executive Officer**

**Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002**

In connection with the quarterly report of LAVA Therapeutics N.V. (the "Company") on Form 10-Q for the period ended September 30, 2025 as filed with the Securities and Exchange Commission on the date hereof (the "Quarterly Report"), I, Stephen Hurly, Chief Executive Officer of the Company, certify, pursuant to Rule 13a-14(b) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to my knowledge:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) The Quarterly Report fully complies with the requirements of Section 13(a) or Section 15(d) of the Exchange Act; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) The information contained in the Quarterly Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date: November 6, 2025

---

| | |
|:---|:---|
| By: | /s/ Stephen Hurly |
| Name: | Stephen Hurly |
| Title: | Chief Executive Officer (Principal Executive Officer) |
|  | *This certification accompanies the Form 10-Q to which it relates, is not deemed filed with the Securities and Exchange Commission and is not to be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Securities Exchange Act or 1934, as amended (whether made before or after the date of the Form 10-Q), irrespective of any general incorporation language contained in such filing.* |

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## Exhibit 32.2

**EXHIBIT 32.2**

**Certification by the Principal Financial Officer**

**Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002**

In connection with the quarterly report of LAVA Therapeutics N.V. (the "Company") on Form 10-Q for the period ended September 30, 2025 as filed with the Securities and Exchange Commission on the date hereof (the "Quarterly Report"), I, Fred Powell, Chief Financial Officer of the Company, certify, pursuant to Rule 13a-14(b) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to my knowledge:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) The Quarterly Report fully complies with the requirements of Section 13(a) or Section 15(d) of the Exchange Act; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) The information contained in the Quarterly Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date: November 6, 2025

---

| | |
|:---|:---|
| By: | /s/ Fred Powell |
| Name: | Fred Powell |
| Title: | Chief Financial Officer (Principal Financial Officer) |
|  | *This certification accompanies the Form 10-Q to which it relates, is not deemed filed with the Securities and Exchange Commission and is not to be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Securities Exchange Act or 1934, as amended (whether made before or after the date of the Form 10-Q), irrespective of any general incorporation language contained in such filing.* |

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