# EDGAR Filing Document

**Accession Number:** 0001940272
**File Stem:** 0001940272-26-000005
**Filing Date:** 2026-5
**Character Count:** 35232
**Document Hash:** a63186c5230cc941d728c60b20fed4ba
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001940272-26-000005.hdr.sgml**: 20260518

**ACCESSION NUMBER**: 0001940272-26-000005

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20260331

**FILED AS OF DATE**: 20260518

**DATE AS OF CHANGE**: 20260515

**EFFECTIVENESS DATE**: 20260518

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** ADAR1 Capital Management, LLC
- **CENTRAL INDEX KEY:** 0001940272

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** TX
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-23931
- **FILM NUMBER:** 26990452

**BUSINESS ADDRESS:**
- **STREET 1:** 3503 WILD CHERRY DRIVE
- **STREET 2:** BUILDING 9
- **CITY:** AUSTIN
- **STATE:** TX
- **ZIP:** 78738
- **BUSINESS PHONE:** 512-254-3790

**MAIL ADDRESS:**
- **STREET 1:** 3503 WILD CHERRY DRIVE
- **STREET 2:** BUILDING 9
- **CITY:** AUSTIN
- **STATE:** TX
- **ZIP:** 78738

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 03-31-2026

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** ADAR1 Capital Management LLC<br>**Address:** 3503 WILD CHERRY DRIVE<br>BUILDING 9<br>AUSTIN, TX 78738

**Form 13F File Number:** 028-23931

**CRD Number (if applicable):** 000299694

**SEC File Number (if applicable):** 801-130082

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Stephen Scipione<br>**Title:** Chief Compliance Officer<br>**Phone:** 5122543790

**Signature, Place, and Date of Signing:**

Stephen Scipione  Austin, TX  05-15-2026<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 311

**Form 13F Information Table Value Total:** $1698675488

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| 4D MOLECULAR THERAPEUTICS IN | COM | 35104E100 |  | 1086589 | 116712 | SH |  | SOLE |  | 116712 | 0 | 0 |
| A SPAC III ACQUISITION CORP | RIGHT 01/02/2026 | G0544A145 |  | 42441 | 215000 | SH |  | SOLE |  | 215000 | 0 | 0 |
| ABIVAX SA | SPONSORED ADS | 00370M103 |  | 155224016 | 1394019 | SH |  | SOLE |  | 0 | 0 | 0 |
| ABIVAX SA | SPONSORED ADS | 00370M103 |  | 2227000 | 20000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| ABIVAX SA | SPONSORED ADS | 00370M103 |  | 2672400 | 24000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| ACHIEVE LIFE SCIENCE INC | COM | 004468500 |  | 140532 | 47800 | SH |  | SOLE |  | 47800 | 0 | 0 |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 |  | 496598 | 132426 | SH |  | SOLE |  | 132426 | 0 | 0 |
| ACUMEN PHARMACEUTICALS INC | COM | 00509G209 |  | 5088948 | 2156334 | SH |  | SOLE |  | 2156334 | 0 | 0 |
| ADAGIO MED HLDGS INC | COM | 00534B100 |  | 1386264 | 1205447 | SH |  | SOLE |  | 1205447 | 0 | 0 |
| ADICET BIO INC | COM NEW | 007002207 |  | 366562 | 53827 | SH |  | SOLE |  | 53827 | 0 | 0 |
| ADLAI NORTYE LTD | SPONSORED ADS | 00704R109 |  | 815930 | 117909 | SH |  | SOLE |  | 117909 | 0 | 0 |
| AGIOS PHARMACEUTICALS INC | COM | 00847X104 |  | 4758934 | 140672 | SH |  | SOLE |  | 140672 | 0 | 0 |
| ALECTOR INC | COM | 014442107 |  | 2257500 | 1050000 | SH |  | SOLE |  | 1050000 | 0 | 0 |
| ALEXANDRIA REAL ESTATE EQ IN | COM | 015271109 |  | 905190 | 19500 | SH |  | SOLE |  | 19500 | 0 | 0 |
| ALIBABA GROUP HLDG LTD | SPONSORED ADS | 01609W102 |  | 448896 | 3578 | SH |  | SOLE |  | 3578 | 0 | 0 |
| ALKERMES PLC | SHS | G01767105 |  | 1640704 | 46400 | SH |  | SOLE |  | 46400 | 0 | 0 |
| AMERICAN EXCEPTIONALISM ACQU | ORD CL A | G0273J101 |  | 3872147 | 357539 | SH |  | SOLE |  | 357539 | 0 | 0 |
| AMICUS THERAPEUTIC | COM | 03152W109 |  | 1518300 | 105000 | SH |  | SOLE |  | 105000 | 0 | 0 |
| AMYLYX PHARMACEUTICALS INC | COM | 03237H101 |  | 13908396 | 1000604 | SH |  | SOLE |  | 1000604 | 0 | 0 |
| AN2 THERAPEUTICS INC | COM | 037326105 |  | 47405 | 13861 | SH |  | SOLE |  | 13861 | 0 | 0 |
| ANAPTYSBIO INC | COM | 032724106 |  | 205091 | 3698 | SH |  | SOLE |  | 3698 | 0 | 0 |
| ANNEXON INC | COM | 03589W102 |  | 304700 | 55000 | SH |  | SOLE |  | 55000 | 0 | 0 |
| ANTERIS TECHNOLOGIES GLOBAL | COM | 03675P102 |  | 21029683 | 3789132 | SH |  | SOLE |  | 3789132 | 0 | 0 |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 |  | 2916675 | 72500 | SH |  | SOLE |  | 72500 | 0 | 0 |
| AQUESTIVE THERAPEUTICS INC | COM | 03843E104 |  | 41500 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| ARBUTUS BIOPHARMA CORP | COM | 03879J100 |  | 14099288 | 3133175 | SH |  | SOLE |  | 3133175 | 0 | 0 |
| ARCELLX INC | COMMON STOCK | 03940C100 |  | 3683885 | 32084 | SH |  | SOLE |  | 32084 | 0 | 0 |
| ARCTURUS THERAPEUTICS HLDGS | COM | 03969T109 |  | 115800 | 15000 | SH |  | SOLE |  | 15000 | 0 | 0 |
| ARDELYX INC | COM | 039697107 |  | 143161 | 23900 | SH |  | SOLE |  | 23900 | 0 | 0 |
| ARRIVENT BIOPHARMA INC | COM | 04272N102 |  | 3271649 | 141814 | SH |  | SOLE |  | 141814 | 0 | 0 |
| ARROWHEAD PHARMACEUTICALS IN | COM | 04280A100 |  | 4407810 | 70300 | SH |  | SOLE |  | 70300 | 0 | 0 |
| ARROWHEAD PHARMACEUTICALS IN | NOTE 1/1 | 04280AAC4 |  | 1024000 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| ARS PHARMACEUTICALS INC | COM | 82835W108 |  | 10933134 | 1361536 | SH |  | SOLE |  | 1361536 | 0 | 0 |
| ARVINAS INC | COM | 04335A105 |  | 610465 | 57591 | SH |  | SOLE |  | 57591 | 0 | 0 |
| ASCENDIS PHARMA A/S | SPONSORED ADR | 04351P101 |  | 5721452 | 25014 | SH |  | SOLE |  | 25014 | 0 | 0 |
| ASSEMBLY BIOSCIENCES INC | COM NEW | 045396207 |  | 553529 | 19947 | SH |  | SOLE |  | 19947 | 0 | 0 |
| ATAIBECKLEY INC | COM SHS | 04650F101 |  | 3232877 | 913242 | SH |  | SOLE |  | 913242 | 0 | 0 |
| ATRIUM THERAPEUTICS INC | COM | 04965N104 |  | 771000 | 57688 | SH |  | SOLE |  | 57688 | 0 | 0 |
| ATYR PHARMA INC | COM NEW | 002120202 |  | 39534 | 50685 | SH |  | SOLE |  | 50685 | 0 | 0 |
| AVANTOR INC | COM | 05352A100 |  | 627200 | 80000 | SH |  | SOLE |  | 80000 | 0 | 0 |
| BEAM THERAPEUTICS INC | COM | 07373V105 |  | 34467116 | 1446375 | SH |  | SOLE |  | 1446375 | 0 | 0 |
| BELITE BIO INC | SPONSORED ADS | 07782B104 |  | 4285747 | 26880 | SH |  | SOLE |  | 26880 | 0 | 0 |
| BENITEC BIOPHARMA INC | COM NEW | 08205P209 |  | 186375 | 17500 | SH |  | SOLE |  | 17500 | 0 | 0 |
| BEONE MEDICINES LTD | SPONSORED ADS | 07725L102 |  | 3474846 | 11701 | SH |  | SOLE |  | 11701 | 0 | 0 |
| BEST SPAC I ACQUISITION CORP | UNIT 05/27/2030 | G1069P137 |  | 1040000 | 100000 | SH |  | SOLE |  | 100000 | 0 | 0 |
| BHAV ACQUISITION CORP | UNIT 03/18/2031 | G1R59W127 |  | 4935000 | 495000 | SH |  | SOLE |  | 495000 | 0 | 0 |
| BICARA THERAPEUTICS INC | COM | 055477103 |  | 272592 | 13705 | SH |  | SOLE |  | 13705 | 0 | 0 |
| BICYCLE THERAPEUTICS PLC | SPONSORED ADS | 088786108 |  | 330823 | 71298 | SH |  | SOLE |  | 71298 | 0 | 0 |
| BIOAGE LABS INC | COM | 09077V100 |  | 2370944 | 135560 | SH |  | SOLE |  | 135560 | 0 | 0 |
| BIOATLA INC | COM | 09077B104 |  | 36725 | 228107 | SH |  | SOLE |  | 228107 | 0 | 0 |
| BIOCRYST PHARMACEUTICALS INC | COM | 09058V103 |  | 999600 | 105000 | SH |  | SOLE |  | 105000 | 0 | 0 |
| BIOGEN INC | COM | 09062X103 |  | 2016630 | 11000 | SH |  | SOLE |  | 11000 | 0 | 0 |
| BIOHAVEN LTD | COM | G1110E107 |  | 378813 | 44777 | SH |  | SOLE |  | 44777 | 0 | 0 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 |  | 1028118 | 18200 | SH |  | SOLE |  | 18200 | 0 | 0 |
| BIOMEA FUSION INC | COM | 09077A106 |  | 66433 | 43420 | SH |  | SOLE |  | 43420 | 0 | 0 |
| BIONTECH SE | SPONSORED ADS | 09075V102 |  | 888800 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| BOSTON SCIENTIFIC CORP | COM | 101137107 |  | 627500 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| BRIDGEBIO PHARMA INC | COM | 10806X102 |  | 7002124 | 94292 | SH |  | SOLE |  | 94292 | 0 | 0 |
| BRIDGEBIO PHARMA INC | NOTE 1.750% 3/0 | 10806XAJ1 |  | 4852000 | 30000 | PRN |  | SOLE |  | 30000 | 0 | 0 |
| BRIDGEBIO PHARMA INC | NOTE 2.250% 2/0 | 10806XAD4 |  | 4943000 | 45000 | PRN |  | SOLE |  | 45000 | 0 | 0 |
| BRIDGEBIO PHARMA INC | NOTE 2.500% 3/1 | 10806XAB8 |  | 3564000 | 20000 | PRN |  | SOLE |  | 20000 | 0 | 0 |
| BRIGHT MINDS BIOSCIENCES INC | COM NEW | 10919W405 |  | 2473683 | 33900 | SH |  | SOLE |  | 33900 | 0 | 0 |
| BRIGHTHOUSE FINL INC | COM | 10922N103 |  | 5719917 | 95523 | SH |  | SOLE |  | 95523 | 0 | 0 |
| BRISTOL-MYERS SQUIBB CO | COM | 110122108 |  | 1061375 | 17500 | SH |  | SOLE |  | 17500 | 0 | 0 |
| C4 THERAPEUTICS INC | COM STK | 12529R107 |  | 113090 | 43000 | SH |  | SOLE |  | 43000 | 0 | 0 |
| CANTOR EQUITY PARTNERS VI IN | CL A ORD SHS | G1828R101 |  | 202000 | 20000 | SH |  | SOLE |  | 20000 | 0 | 0 |
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 |  | 2754027 | 90593 | SH |  | SOLE |  | 90593 | 0 | 0 |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 |  | 13570324 | 427816 | SH |  | SOLE |  | 427816 | 0 | 0 |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 |  | 1531842 | 38566 | SH |  | SOLE |  | 38566 | 0 | 0 |
| CG ONCOLOGY INC | COM | 156944100 |  | 12568108 | 185699 | SH |  | SOLE |  | 185699 | 0 | 0 |
| CHEMOMAB THERAPEUTICS LTD | SPONSORED ADS | 16385C203 |  | 125600 | 80000 | SH |  | SOLE |  | 80000 | 0 | 0 |
| CLIMB BIO INC | COM | 28658R106 |  | 4093985 | 597662 | SH |  | SOLE |  | 597662 | 0 | 0 |
| CLOVER HEALTH INVESTMENTS CO | COM CL A | 18914F103 |  | 70400 | 40000 | SH |  | SOLE |  | 40000 | 0 | 0 |
| COHEN CIRCLE ACQUISIT CORP I | UNIT 07/01/2030 | G2254C105 |  | 1551000 | 150000 | SH |  | SOLE |  | 150000 | 0 | 0 |
| COHERUS ONCOLOGY INC | COM | 19249H103 |  | 17519 | 10366 | SH |  | SOLE |  | 10366 | 0 | 0 |
| COMPASS THERAPEUTICS INC | COM | 20454B104 |  | 735310 | 139000 | SH |  | SOLE |  | 139000 | 0 | 0 |
| CONNECT BIOPHARMA HLDGS LTD | SHS | G23549101 |  | 1945088 | 742400 | SH |  | SOLE |  | 742400 | 0 | 0 |
| CONTEXT THERAPEUTICS INC | COM | 21077P108 |  | 919866 | 351094 | SH |  | SOLE |  | 351094 | 0 | 0 |
| CONTINEUM THERAPEUTICS INC | CL A | 21217B100 |  | 3613193 | 276661 | SH |  | SOLE |  | 276661 | 0 | 0 |
| CORBUS PHARMACEUTICALS HLDGS | COM NEW | 21833P301 |  | 3115424 | 331781 | SH |  | SOLE |  | 331781 | 0 | 0 |
| CORBUS PHARMACEUTICALS HLDGS | COM NEW | 21833P301 |  | 328650 | 35000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| CORCEPT THERAPEUTICS INC | COM | 218352102 |  | 322480 | 8000 | SH |  | SOLE |  | 8000 | 0 | 0 |
| CORE SCIENTIFIC INC NEW | COM | 21874A106 |  | 448800 | 30000 | SH |  | SOLE |  | 30000 | 0 | 0 |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 |  | 1285992 | 87901 | SH |  | SOLE |  | 87901 | 0 | 0 |
| COYA THERAPEUTICS INC | COMMON STOCK | 22407B108 |  | 161146 | 40900 | SH |  | SOLE |  | 40900 | 0 | 0 |
| CRESCENT BIOPHARMA INC. | COM | G2545C104 |  | 923515 | 50273 | SH |  | SOLE |  | 50273 | 0 | 0 |
| CRINETICS PHARMACEUTICALS IN | COM | 22663K107 |  | 41380502 | 1139331 | SH |  | SOLE |  | 1139331 | 0 | 0 |
| CROWDSTRIKE HLDGS INC | CL A | 22788C105 |  | 249862 | 640 | SH |  | SOLE |  | 640 | 0 | 0 |
| CULLINAN THERAPEUTICS INC | COM | 230031106 |  | 710500 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| CYBIN INC | COM NEW | 23256X407 |  | 150134 | 31278 | SH |  | SOLE |  | 31278 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 41691766 | 632556 | SH |  | SOLE |  | 632556 | 0 | 0 |
| CYTOMX THERAPEUTICS INC. | COM | 23284F105 |  | 16027893 | 3410190 | SH |  | SOLE |  | 3410190 | 0 | 0 |
| DAMORA THERAPEUTICS INC | COM NEW | 36322Q206 |  | 7226100 | 279000 | SH |  | SOLE |  | 279000 | 0 | 0 |
| DANAHER CORP DEL | COM | 235851102 |  | 5864707 | 30932 | SH |  | SOLE |  | 30932 | 0 | 0 |
| DAY ONE BIOPHARMACEUTICALS I | COM | 23954D109 |  | 1070349 | 49923 | SH |  | SOLE |  | 49923 | 0 | 0 |
| DBV TECHNOLOGIES S A | SPONSORED ADS | 23306J309 |  | 21158771 | 1012866 | SH |  | SOLE |  | 1012866 | 0 | 0 |
| DELCATH SYS INC | COM NEW | 24661P807 |  | 2082293 | 224385 | SH |  | SOLE |  | 224385 | 0 | 0 |
| DENALI THERAPEUTICS INC | COM | 24823R105 |  | 35931936 | 1871455 | SH |  | SOLE |  | 1871455 | 0 | 0 |
| DESIGN THERAPEUTICS INC | COM | 25056L103 |  | 106400 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| DIANTHUS THERAPEUTICS INC | COM | 252828108 |  | 4615600 | 55000 | SH |  | SOLE |  | 55000 | 0 | 0 |
| DYNE THERAPEUTICS INC | COM | 26818M108 |  | 860504 | 47463 | SH |  | SOLE |  | 47463 | 0 | 0 |
| EA SERIES TRUST | ALPHA ARCH 1-3 | 02072L565 |  | 39204266 | 337125 | SH |  | SOLE |  | 337125 | 0 | 0 |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 |  | 2853869 | 90599 | SH |  | SOLE |  | 90599 | 0 | 0 |
| ELANCO ANIMAL HEALTH INC | COM | 28414H103 |  | 478600 | 20000 | SH |  | SOLE |  | 20000 | 0 | 0 |
| ELECTRONIC ARTS INC | COM | 285512109 |  | 1006302 | 4936 | SH |  | SOLE |  | 4936 | 0 | 0 |
| ELEDON PHARMACEUTICALS INC | COM | 28617K101 |  | 3001217 | 974421 | SH |  | SOLE |  | 974421 | 0 | 0 |
| ELI LILLY  CO | COM | 532457108 |  | 4654036 | 5060 | SH |  | SOLE |  | 5060 | 0 | 0 |
| ENANTA PHARMACEUTICALS INC | COM | 29251M106 |  | 648639 | 51357 | SH |  | SOLE |  | 51357 | 0 | 0 |
| ENGENE HOLDINGS INC | COM | 29286M105 |  | 910402 | 133686 | SH |  | SOLE |  | 133686 | 0 | 0 |
| ENLIVEN THERAPEUTICS INC | COM | 29337E102 |  | 12917968 | 329540 | SH |  | SOLE |  | 329540 | 0 | 0 |
| ENTRADA THERAPEUTICS INC | COM | 29384C108 |  | 384910 | 30500 | SH |  | SOLE |  | 30500 | 0 | 0 |
| EQUILLIUM INC | COM | 29446K106 |  | 7453318 | 3726659 | SH |  | SOLE |  | 3726659 | 0 | 0 |
| ERASCA INC | COM | 29479A108 |  | 161800 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| ESPERION THERAPEUTICS INC NE | COM | 29664W105 |  | 58636 | 21400 | SH |  | SOLE |  | 21400 | 0 | 0 |
| ESTABLISHMENT LABS HLDGS INC | COM | G31249108 |  | 12120997 | 213473 | SH |  | SOLE |  | 213473 | 0 | 0 |
| EVOLUS INC | COM | 30052C107 |  | 229580 | 55859 | SH |  | SOLE |  | 55859 | 0 | 0 |
| EVOMMUNE INC | COM SHS | 30054Y107 |  | 4231585 | 184062 | SH |  | SOLE |  | 184062 | 0 | 0 |
| FORWARD AIR CORP | COM | 34986A104 |  | 1307407 | 78241 | SH |  | SOLE |  | 78241 | 0 | 0 |
| FRACTYL HEALTH INC | COM | 35168W103 |  | 654000 | 1428571 | SH | Call | SOLE |  | 0 | 0 | 0 |
| FULCRUM THERAPEUTICS INC | COM | 359616109 |  | 1001395 | 130560 | SH |  | SOLE |  | 130560 | 0 | 0 |
| GERON CORP | COM | 374163103 |  | 298000 | 200000 | SH |  | SOLE |  | 200000 | 0 | 0 |
| GILEAD SCIENCES INC | COM | 375558103 |  | 885139 | 6351 | SH |  | SOLE |  | 6351 | 0 | 0 |
| GLOBA TERRA ACQUISITION COR | UNIT 99/99/9999 | G3933N108 |  | 518000 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| GLOBUS MED INC | CL A | 379577208 |  | 1731816 | 20100 | SH |  | SOLE |  | 20100 | 0 | 0 |
| GOSSAMER BIO INC | COM | 38341P102 |  | 94454 | 287531 | SH |  | SOLE |  | 287531 | 0 | 0 |
| GUARDANT HEALTH INC | COM | 40131M109 |  | 923700 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| HELIX ACQUISITION CORP III | USD CL A ORD SHS | G4444S107 |  | 10300000 | 1000000 | SH |  | SOLE |  | 1000000 | 0 | 0 |
| IBIO INC | COM NEW | 451033708 |  | 892768 | 469878 | SH |  | SOLE |  | 469878 | 0 | 0 |
| IDEAYA BIOSCIENCES INC | COM | 45166A102 |  | 666400 | 20000 | SH |  | SOLE |  | 20000 | 0 | 0 |
| IMMIX BIOPHARMA INC | COM | 45258H106 |  | 91100 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| IMMUNIC INC | COM | 4525EP101 |  | 0 | 30000 | SH |  | SOLE |  | 30000 | 0 | 0 |
| IMMUNOVANT INC | COM | 45258J102 |  | 66546608 | 2679010 | SH |  | SOLE |  | 2679010 | 0 | 0 |
| INFLARX NV | COM | N44821101 |  | 141558 | 158271 | SH |  | SOLE |  | 158271 | 0 | 0 |
| INHIBIKASE THERAPEUTICS INC | COM NEW | 45719W205 |  | 11099041 | 6606572 | SH |  | SOLE |  | 6606572 | 0 | 0 |
| INOVIO PHARMACEUTICALS INC | COM SHS | 45773H409 |  | 2557988 | 1470108 | SH |  | SOLE |  | 1470108 | 0 | 0 |
| INSMED INC | COM PAR $.01 | 457669307 |  | 5787300 | 35392 | SH |  | SOLE |  | 35392 | 0 | 0 |
| INSPIRE MED SYS INC | COM | 457730109 |  | 20900061 | 405197 | SH |  | SOLE |  | 405197 | 0 | 0 |
| INTEGER HLDGS CORP | COM | 45826H109 |  | 770000 | 8750 | SH |  | SOLE |  | 8750 | 0 | 0 |
| INTELLIA THERAPEUTICS INC | COM | 45826J105 |  | 250208 | 19517 | SH |  | SOLE |  | 19517 | 0 | 0 |
| INTUITIVE SURGICAL INC | COM NEW | 46120E602 |  | 843612 | 1830 | SH |  | SOLE |  | 1830 | 0 | 0 |
| INVENTIVA SA | ADS | 46124U107 |  | 12067909 | 2174398 | SH |  | SOLE |  | 2174398 | 0 | 0 |
| INVIVYD INC | COM | 00534A102 |  | 4969155 | 3822427 | SH |  | SOLE |  | 3822427 | 0 | 0 |
| IONIS PHARMACEUTICALS INC | COM | 462222100 |  | 12039780 | 160338 | SH |  | SOLE |  | 160338 | 0 | 0 |
| ISHARES TR | RUSSELL 2000 ETF | 464287655 |  | 6820000 | 27500 | SH | Put | SOLE |  | 27500 | 0 | 0 |
| JADE BIOSCIENCES INC | COM NEW | 008064206 |  | 281000 | 20000 | SH |  | SOLE |  | 20000 | 0 | 0 |
| JANUX THERAPEUTICS INC | COM | 47103J105 |  | 4149789 | 298546 | SH |  | SOLE |  | 298546 | 0 | 0 |
| JASPER THERAPEUTICS INC | COM NEW | 471871202 |  | 122668 | 140000 | SH |  | SOLE |  | 140000 | 0 | 0 |
| JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 |  | 567150 | 3000 | SH |  | SOLE |  | 3000 | 0 | 0 |
| JD.COM INC | SPON ADS CL A | 47215P106 |  | 295700 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| KALA BIO INC | COM NEW | 483119202 |  | 24490 | 141480 | SH |  | SOLE |  | 141480 | 0 | 0 |
| KALARIS THERAPEUTICS INC | COM | 482929106 |  | 577000 | 100000 | SH |  | SOLE |  | 100000 | 0 | 0 |
| KALVISTA PHARMACEUTICALS INC | COM | 483497103 |  | 201300 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| KARYOPHARM THERAPEUTICS INC | COM NEW | 48576U205 |  | 761620 | 136736 | SH |  | SOLE |  | 136736 | 0 | 0 |
| KARYOPHARM THERAPEUTICS INC | COM NEW | 48576U205 |  | 1142964 | 205200 | SH | Call | SOLE |  | 0 | 0 | 0 |
| KEEN VISION ACQUISITION CORP | SHS | G52443119 |  | 900000 | 75000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| KEROS THERAPEUTICS INC | COM | 492327101 |  | 1074391 | 97318 | SH |  | SOLE |  | 97318 | 0 | 0 |
| KEZAR LIFE SCIENCES INC | COM NEW | 49372L209 |  | 607943 | 81933 | SH |  | SOLE |  | 81933 | 0 | 0 |
| KINIKSA PHARMACEUTICALS INTL | ORD SHS CL A | G52694109 |  | 1295861 | 26913 | SH |  | SOLE |  | 26913 | 0 | 0 |
| KIORA PHARMACEUTICALS INC | COM | 49721T507 |  | 324126 | 167941 | SH |  | SOLE |  | 167941 | 0 | 0 |
| KORRO BIO INC | COM | 500946108 |  | 6113411 | 540054 | SH |  | SOLE |  | 540054 | 0 | 0 |
| KRYSTAL BIOTECH INC | COM | 501147102 |  | 5170016 | 20014 | SH |  | SOLE |  | 20014 | 0 | 0 |
| KURA ONCOLOGY INC | COM | 50127T109 |  | 325200 | 40000 | SH |  | SOLE |  | 40000 | 0 | 0 |
| KYNTRA BIO INC | COM NEW | 31572Q881 |  | 70980 | 10469 | SH |  | SOLE |  | 10469 | 0 | 0 |
| KYVERNA THERAPEUTICS INC | COM | 501976104 |  | 193554 | 22428 | SH |  | SOLE |  | 22428 | 0 | 0 |
| LARIMAR THERAPEUTICS INC | COM | 517125100 |  | 237353 | 52745 | SH |  | SOLE |  | 52745 | 0 | 0 |
| LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 |  | 361800 | 20000 | SH |  | SOLE |  | 20000 | 0 | 0 |
| LEONABIO INC | COM | 04746L203 |  | 7478505 | 727481 | SH |  | SOLE |  | 727481 | 0 | 0 |
| LEXEO THERAPEUTICS INC | COM | 52886X107 |  | 8422589 | 1467350 | SH |  | SOLE |  | 1467350 | 0 | 0 |
| LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 |  | 1170000 | 750000 | SH |  | SOLE |  | 750000 | 0 | 0 |
| LIPOCINE INC NEW | COM NEW | 53630X203 |  | 185208 | 23180 | SH |  | SOLE |  | 23180 | 0 | 0 |
| LIQUIDIA CORPORATION | COM NEW | 53635D202 |  | 3774000 | 100000 | SH | Put | SOLE |  | 100000 | 0 | 0 |
| LITE STRATEGY INC | COM | 55279B301 |  | 78059 | 67292 | SH |  | SOLE |  | 67292 | 0 | 0 |
| LONGEVERON INC | CL A NEW | 54303L203 |  | 208000 | 200000 | SH |  | SOLE |  | 200000 | 0 | 0 |
| MACROGENICS INC | COM | 556099109 |  | 115600 | 40000 | SH |  | SOLE |  | 40000 | 0 | 0 |
| MADRIGAL PHARMACEUTICALS INC | COM | 558868105 |  | 468506 | 895 | SH |  | SOLE |  | 895 | 0 | 0 |
| MAPLIGHT THERAPEUTICS INC | COM | 56565P103 |  | 7621900 | 374909 | SH |  | SOLE |  | 374909 | 0 | 0 |
| MASIMO CORP | COM | 574795100 |  | 2668050 | 15000 | SH |  | SOLE |  | 15000 | 0 | 0 |
| MAZE THERAPEUTICS INC | COM | 578784100 |  | 1495336 | 50095 | SH |  | SOLE |  | 50095 | 0 | 0 |
| MCKESSON CORP | COM | 58155Q103 |  | 1038432 | 1200 | SH |  | SOLE |  | 1200 | 0 | 0 |
| MERCK  CO INC | COM | 58933Y105 |  | 377711 | 3140 | SH |  | SOLE |  | 3140 | 0 | 0 |
| MEREO BIOPHARMA GROUP PLC | SPON ADS | 589492107 |  | 49500 | 150000 | SH |  | SOLE |  | 150000 | 0 | 0 |
| MILESTONE PHARMACEUTICALS IN | COM | 59935V107 |  | 119000 | 100000 | SH |  | SOLE |  | 100000 | 0 | 0 |
| MINERALYS THERAPEUTICS INC | COM | 603170101 |  | 4190444 | 154686 | SH |  | SOLE |  | 154686 | 0 | 0 |
| MIRUM PHARMACEUTICALS INC | COM | 604749101 |  | 572756 | 6200 | SH |  | SOLE |  | 6200 | 0 | 0 |
| MONOPAR THERAPEUTICS INC | COM NEW | 61023L207 |  | 14479792 | 264278 | SH |  | SOLE |  | 264278 | 0 | 0 |
| MONTE ROSA THERAPEUTICS INC | COM | 61225M102 |  | 3549120 | 215752 | SH |  | SOLE |  | 215752 | 0 | 0 |
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 |  | 372800 | 20000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 |  | 8521034 | 457137 | SH |  | SOLE |  | 457137 | 0 | 0 |
| NATERA INC | COM | 632307104 |  | 429379 | 2147 | SH |  | SOLE |  | 2147 | 0 | 0 |
| NEKTAR THERAPEUTICS | COM NEW | 640268306 |  | 11602081 | 161252 | SH |  | SOLE |  | 161252 | 0 | 0 |
| NEUMORA THERAPEUTICS INC. | COM | 640979100 |  | 64545 | 33100 | SH |  | SOLE |  | 33100 | 0 | 0 |
| NEUPHORIA THERAPEUTICS INC | COM | 64136E102 |  | 122100 | 30000 | SH |  | SOLE |  | 30000 | 0 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 |  | 329350 | 2500 | SH |  | SOLE |  | 2500 | 0 | 0 |
| NEURONETICS INC | COM | 64131A105 |  | 145000 | 100000 | SH |  | SOLE |  | 100000 | 0 | 0 |
| NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | N62509109 |  | 3797122 | 118623 | SH |  | SOLE |  | 118623 | 0 | 0 |
| NOVO-NORDISK A S | ADR | 670100205 |  | 1212750 | 33000 | SH |  | SOLE |  | 33000 | 0 | 0 |
| NOVO-NORDISK A S | ADR | 670100205 |  | 477750 | 13000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| NURIX THERAPEUTICS INC | COM | 67080M103 |  | 869085 | 56070 | SH |  | SOLE |  | 56070 | 0 | 0 |
| NUVALENT INC | COM | 670703107 |  | 711208 | 6942 | SH |  | SOLE |  | 6942 | 0 | 0 |
| NUVATION BIO INC | COM CL A | 67080N101 |  | 186615 | 43500 | SH |  | SOLE |  | 43500 | 0 | 0 |
| OAKTREE ACQUISITION CORP III | UNIT 10/04/2029 | G6717R120 |  | 5500533 | 516482 | SH |  | SOLE |  | 516482 | 0 | 0 |
| OMNIAB INC | COM | 68218J103 |  | 1107148 | 705190 | SH |  | SOLE |  | 705190 | 0 | 0 |
| ONKURE THERAPEUTICS INC | COM CL A | 68277Q105 |  | 10080656 | 2434941 | SH |  | SOLE |  | 2434941 | 0 | 0 |
| OPUS GENETICS INC | COM | 67577R102 |  | 8412968 | 1849004 | SH |  | SOLE |  | 1849004 | 0 | 0 |
| ORGANON  CO | COMMON STOCK | 68622V106 |  | 59900 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| ORTHOPEDIATRICS CORP | COM | 68752L100 |  | 314940 | 19845 | SH |  | SOLE |  | 19845 | 0 | 0 |
| ORUKA THERAPEUTICS INC | COM | 687604108 |  | 1022202 | 20840 | SH |  | SOLE |  | 20840 | 0 | 0 |
| OVID THERAPEUTICS INC | COM | 690469101 |  | 10087931 | 4544113 | SH |  | SOLE |  | 4544113 | 0 | 0 |
| PALISADE BIO INC | COM | 696389402 |  | 3963479 | 2264845 | SH |  | SOLE |  | 2264845 | 0 | 0 |
| PALO ALTO NETWORKS INC | COM | 697435105 |  | 256512 | 1600 | SH |  | SOLE |  | 1600 | 0 | 0 |
| PEPGEN INC | COM | 713317105 |  | 2845519 | 1607638 | SH |  | SOLE |  | 1607638 | 0 | 0 |
| PERCEPTIVE CAP SOLUTIONS COR | CL A ORD SHS | G70077105 |  | 5480404 | 499581 | SH |  | SOLE |  | 499581 | 0 | 0 |
| PERSONALIS INC | COM | 71535D106 |  | 159250 | 25000 | SH |  | SOLE |  | 25000 | 0 | 0 |
| PERSPECTIVE THERAPEUTICS INC | COM NEW | 46489V302 |  | 3124727 | 749335 | SH |  | SOLE |  | 749335 | 0 | 0 |
| PFIZER INC | COM | 717081103 |  | 2173392 | 77400 | SH |  | SOLE |  | 77400 | 0 | 0 |
| PHARVARIS N V | COM | N69605108 |  | 2981166 | 105528 | SH |  | SOLE |  | 105528 | 0 | 0 |
| PHATHOM PHARMACEUTICALS INC | COM | 71722W107 |  | 476619 | 42900 | SH |  | SOLE |  | 42900 | 0 | 0 |
| PLIANT THERAPEUTICS INC | COM | 729139105 |  | 3257259 | 2585126 | SH |  | SOLE |  | 2585126 | 0 | 0 |
| PMV PHARMACEUTICALS INC | COM | 69353Y103 |  | 286450 | 231008 | SH |  | SOLE |  | 231008 | 0 | 0 |
| POLYPID LTD | COM | M8001Q126 |  | 455301 | 103950 | SH |  | SOLE |  | 103950 | 0 | 0 |
| PRAXIS PRECISION MEDICINES I | COM NEW | 74006W207 |  | 483285 | 1500 | SH |  | SOLE |  | 1500 | 0 | 0 |
| PRELUDE THERAPEUTICS INC | COM | 74065P101 |  | 522662 | 152825 | SH |  | SOLE |  | 152825 | 0 | 0 |
| PRIME MEDICINE INC | COM | 74168J101 |  | 6867021 | 1973282 | SH |  | SOLE |  | 1973282 | 0 | 0 |
| PROCAP ACQUISITION CORP | UNIT 05/16/2030 | G7257A113 |  | 278560 | 26940 | SH |  | SOLE |  | 26940 | 0 | 0 |
| PROMIS NEUROSCIENCES INC | COM SHS | 74346M505 |  | 1210945 | 95350 | SH |  | SOLE |  | 95350 | 0 | 0 |
| PROQR THRAPEUTICS N V | SHS EURO | N71542109 |  | 16200 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 |  | 104780143 | 994119 | SH |  | SOLE |  | 994119 | 0 | 0 |
| PROTARA THERAPEUTICS INC | COM STK | 74365U107 |  | 4900068 | 940512 | SH |  | SOLE |  | 940512 | 0 | 0 |
| PROTHENA CORP PLC | SHS | G72800108 |  | 15371626 | 1581443 | SH |  | SOLE |  | 1581443 | 0 | 0 |
| PULMONX CORP | COM | 745848101 |  | 483101 | 374497 | SH |  | SOLE |  | 374497 | 0 | 0 |
| Q/C TECHNOLOGIES INC | COM | 62856X300 |  | 172500 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| Q32 BIO INC | COM | 746964105 |  | 224700 | 35000 | SH |  | SOLE |  | 35000 | 0 | 0 |
| QUINCE THERAPEUTICS INC | COM | 22053A107 |  | 5070 | 50000 | SH | Put | SOLE |  | 50000 | 0 | 0 |
| QUINCE THERAPEUTICS INC | COM | 22053A107 |  | 5080 | 50100 | SH |  | SOLE |  | 50100 | 0 | 0 |
| RALLYBIO CORP | COM | 75120L209 |  | 184199 | 20535 | SH |  | SOLE |  | 20535 | 0 | 0 |
| RECURSION PHARMACEUTICALS IN | CL A | 75629V104 |  | 107450 | 35000 | SH |  | SOLE |  | 35000 | 0 | 0 |
| REGENERON PHARMACEUTICALS | COM | 75886F107 |  | 9390667 | 12154 | SH |  | SOLE |  | 12154 | 0 | 0 |
| REGENXBIO INC | COM | 75901B107 |  | 372206 | 44416 | SH |  | SOLE |  | 44416 | 0 | 0 |
| RELMADA THERAPEUTICS INC | COM | 75955J402 |  | 3145349 | 451918 | SH |  | SOLE |  | 451918 | 0 | 0 |
| REPLIMUNE GROUP INC | COM | 76029N106 |  | 765000 | 100000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| REPLIMUNE GROUP INC | COM | 76029N106 |  | 12109851 | 1582987 | SH |  | SOLE |  | 1582987 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 13021094 | 133893 | SH |  | SOLE |  | 133893 | 0 | 0 |
| REZOLUTE INC | COM NEW | 76200L309 |  | 178971 | 58679 | SH |  | SOLE |  | 58679 | 0 | 0 |
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 |  | 18389807 | 211450 | SH |  | SOLE |  | 211450 | 0 | 0 |
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 |  | 1548350 | 432500 | SH |  | SOLE |  | 432500 | 0 | 0 |
| ROIVANT SCIENCES LTD | SHS | G76279101 |  | 91019596 | 3285906 | SH |  | SOLE |  | 3285906 | 0 | 0 |
| ROYALTY PHARMA PLC | SHS CLASS A | G7709Q104 |  | 239850 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| RUBRIK INC. | CL A | 781154109 |  | 239953 | 4900 | SH |  | SOLE |  | 4900 | 0 | 0 |
| RXSIGHT INC | COM | 78349D107 |  | 266420 | 43250 | SH |  | SOLE |  | 43250 | 0 | 0 |
| SANOFI SA | SPONSORED ADR | 80105N105 |  | 15270121 | 316939 | SH |  | SOLE |  | 316939 | 0 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607100 |  | 5702382 | 262058 | SH |  | SOLE |  | 262058 | 0 | 0 |
| SATELLOS BIOSCIENCE INC | COM | 80401L803 |  | 1253000 | 222555 | SH |  | SOLE |  | 222555 | 0 | 0 |
| SAVARA INC | COM | 805111101 |  | 7996361 | 1464535 | SH |  | SOLE |  | 1464535 | 0 | 0 |
| SCHOLAR ROCK HLDG CORP | COM | 80706P103 |  | 20021541 | 407273 | SH |  | SOLE |  | 407273 | 0 | 0 |
| SCHRODINGER INC | COM | 80810D103 |  | 1153040 | 101500 | SH |  | SOLE |  | 101500 | 0 | 0 |
| SENSIENT TECHNOLOGIES CORP | COM | 81725T100 |  | 1296600 | 15000 | SH |  | SOLE |  | 15000 | 0 | 0 |
| SEPTERNA INC | COM | 81734D104 |  | 26188327 | 1089818 | SH |  | SOLE |  | 1089818 | 0 | 0 |
| SI BONE INC | COM | 825704109 |  | 158885 | 12580 | SH |  | SOLE |  | 12580 | 0 | 0 |
| SILENCE THERAPEUTICS PLC | ADS | 82686Q101 |  | 907267 | 172157 | SH |  | SOLE |  | 172157 | 0 | 0 |
| SOLENO THERAPEUTICS INC | COM | 834203309 |  | 1567868 | 46830 | SH |  | SOLE |  | 46830 | 0 | 0 |
| SOLIDION TECHNOLOGY INC | COM NEW | 834212201 |  | 85185 | 13500 | SH | Call | SOLE |  | 0 | 0 | 0 |
| SPDR SERIES TRUST | STATE STREET SPD | 78468R663 |  | 12425009 | 135585 | SH |  | SOLE |  | 135585 | 0 | 0 |
| SPDR SERIES TRUST | STATE STREET SPD | 78464A870 |  | 1915950 | 15000 | SH | Put | SOLE |  | 15000 | 0 | 0 |
| SPRUCE BIOSCIENCES INC | COM NEW | 85209E208 |  | 3829510 | 58600 | SH |  | SOLE |  | 58600 | 0 | 0 |
| SPYRE THERAPEUTICS INC | COM NEW | 00773J202 |  | 17065012 | 338323 | SH |  | SOLE |  | 338323 | 0 | 0 |
| STATE STR SPDR S 500 ETF T | TR UNIT | 78462F103 |  | 49386820 | 75940 | SH |  | SOLE |  | 75940 | 0 | 0 |
| SUMMIT THERAPEUTICS INC | COM | 86627T108 |  | 1741836 | 91869 | SH |  | SOLE |  | 91869 | 0 | 0 |
| SUPERNUS PHARMACEUTICALS | COM | 868459108 |  | 1532195 | 29642 | SH |  | SOLE |  | 29642 | 0 | 0 |
| SURGERY PARTNERS INC | COM | 86881A100 |  | 238400 | 20000 | SH |  | SOLE |  | 20000 | 0 | 0 |
| SURROZEN INC | COM NEW | 86889P208 |  | 349560 | 12000 | SH |  | SOLE |  | 12000 | 0 | 0 |
| SUTRO BIOPHARMA INC | COM SHS | 869367201 |  | 13063825 | 524441 | SH |  | SOLE |  | 524441 | 0 | 0 |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 |  | 408800 | 17500 | SH |  | SOLE |  | 17500 | 0 | 0 |
| TANGO THERAPEUTICS INC | COM | 87583X109 |  | 1046000 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| TAYSHA GENE THERAPIES INC | COM SHS | 877619106 |  | 13318048 | 2979429 | SH |  | SOLE |  | 2979429 | 0 | 0 |
| TECTONIC THERAPEUTIC INC | COM | 878972108 |  | 401861 | 13001 | SH |  | SOLE |  | 13001 | 0 | 0 |
| TELEFLEX INCORPORATED | COM | 879369106 |  | 2534057 | 21186 | SH |  | SOLE |  | 21186 | 0 | 0 |
| TENAX THERAPEUTICS INC | COM NEW | 88032L605 |  | 3413257 | 213462 | SH |  | SOLE |  | 213462 | 0 | 0 |
| TENAYA THERAPEUTICS INC | COM | 87990A106 |  | 1044001 | 1507800 | SH |  | SOLE |  | 1507800 | 0 | 0 |
| TERNS PHARMACEUTICALS INC | COM | 880881107 |  | 10544000 | 200000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| TERNS PHARMACEUTICALS INC | COM | 880881107 |  | 48222931 | 914699 | SH |  | SOLE |  | 914699 | 0 | 0 |
| TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADS | 881624209 |  | 8083937 | 268391 | SH |  | SOLE |  | 268391 | 0 | 0 |
| THE ONCOLOGY INSTITUTE INC | COM | 68236X100 |  | 153500 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| THERAPEUTICSMD INC | COM NEW | 88338N206 |  | 422604 | 209210 | SH |  | SOLE |  | 209210 | 0 | 0 |
| TRAWS PHARMA INC | COM NEW | 68232V884 |  | 281999 | 154098 | SH |  | SOLE |  | 154098 | 0 | 0 |
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 |  | 419000 | 20000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 |  | 280730 | 13400 | SH |  | SOLE |  | 13400 | 0 | 0 |
| UNIQURE NV | SHS | N90064101 |  | 1635000 | 100000 | SH | Call | SOLE |  | 0 | 0 | 0 |
| UNIQURE NV | SHS | N90064101 |  | 1245968 | 76206 | SH |  | SOLE |  | 76206 | 0 | 0 |
| UNITEDHEALTH GROUP INC | COM | 91324P102 |  | 1488516 | 5501 | SH |  | SOLE |  | 5501 | 0 | 0 |
| UPSTREAM BIO INC | COM | 91678A107 |  | 315000 | 35000 | SH |  | SOLE |  | 35000 | 0 | 0 |
| UROGEN PHARMA LTD | COM | M96088105 |  | 7110353 | 395459 | SH |  | SOLE |  | 395459 | 0 | 0 |
| VAXCYTE INC | COM | 92243G108 |  | 15058451 | 259137 | SH |  | SOLE |  | 259137 | 0 | 0 |
| VERA THERAPEUTICS INC | CL A | 92337R101 |  | 645008 | 16033 | SH |  | SOLE |  | 16033 | 0 | 0 |
| VERASTEM INC | COM NEW | 92337C203 |  | 376830 | 71100 | SH |  | SOLE |  | 71100 | 0 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 |  | 6731591 | 15075 | SH |  | SOLE |  | 15075 | 0 | 0 |
| VERU INC | COM NEW | 92536C202 |  | 77350 | 35000 | SH |  | SOLE |  | 35000 | 0 | 0 |
| VIKING THERAPEUTICS INC | COM | 92686J106 |  | 7409911 | 227717 | SH |  | SOLE |  | 227717 | 0 | 0 |
| VIR BIOTECHNOLOGY INC | COM | 92764N102 |  | 24592637 | 2744714 | SH |  | SOLE |  | 2744714 | 0 | 0 |
| VIRIDIAN THERAPEUTICS INC | COM | 92790C104 |  | 5954494 | 304422 | SH |  | SOLE |  | 304422 | 0 | 0 |
| VISTAGEN THERAPEUTICS INC | COM | 92840H400 |  | 429277 | 751141 | SH |  | SOLE |  | 751141 | 0 | 0 |
| VOYAGER THERAPEUTICS INC | COM | 92915B106 |  | 135100 | 35000 | SH |  | SOLE |  | 35000 | 0 | 0 |
| VYNE THERAPEUTICS INC | COM | 92941V308 |  | 635680 | 1063899 | SH |  | SOLE |  | 1063899 | 0 | 0 |
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 |  | 325525 | 44900 | SH |  | SOLE |  | 44900 | 0 | 0 |
| WHITEHAWK THERAPEUTICS INC | COM | 00032Q104 |  | 443335 | 128503 | SH |  | SOLE |  | 128503 | 0 | 0 |
| WISDOMTREE TR | FLOATNG RAT TREA | 97717Y527 |  | 503400 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| WW INTL INC | COM NEW | 98262P200 |  | 792798 | 57700 | SH |  | SOLE |  | 57700 | 0 | 0 |
| XENCOR INC | COM | 98401F105 |  | 1129600 | 93665 | SH |  | SOLE |  | 93665 | 0 | 0 |
| XENON PHARMACEUTICALS INC | COM | 98420N105 |  | 13310477 | 228899 | SH |  | SOLE |  | 228899 | 0 | 0 |
| ZAI LAB LTD | ADR | 98887Q104 |  | 26811153 | 1425367 | SH |  | SOLE |  | 1425367 | 0 | 0 |
| ZENTALIS PHARMACEUTICALS INC | COM | 98943L107 |  | 338448 | 144636 | SH |  | SOLE |  | 144636 | 0 | 0 |
| ZURA BIO LTD | CLASS A ORD SHS | G9TY5A101 |  | 3750898 | 630403 | SH |  | SOLE |  | 630403 | 0 | 0 |

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