# EDGAR Filing Document

**Accession Number:** 0001253689
**File Stem:** 0001628280-26-001951
**Filing Date:** 2026-1
**Character Count:** 2623
**Document Hash:** 377a4bc639c7af3a86d809fe616df8bd
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001628280-26-001951.hdr.sgml**: 20260224

**ACCESSION NUMBER**: 0001628280-26-001951

**CONFORMED SUBMISSION TYPE**: CORRESP

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20260113

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** CRESCENT BIOPHARMA, INC.
- **CENTRAL INDEX KEY:** 0001253689
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** E9
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** CORRESP

**BUSINESS ADDRESS:**
- **STREET 1:** 300 FIFTH AVENUE
- **CITY:** WALTHAM
- **STATE:** MA
- **ZIP:** 02451
- **BUSINESS PHONE:** 617-430-5595

**MAIL ADDRESS:**
- **STREET 1:** 300 FIFTH AVENUE
- **CITY:** WALTHAM
- **STATE:** MA
- **ZIP:** 02451

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** GLYCOMIMETICS INC
- **DATE OF NAME CHANGE:** 20030711

**CRESCENT BIOPHARMA, INC.**

300 Fifth Avenue

Waltham, MA 02451

January 13, 2026

**<u>VIA EDGAR TRANSMISSION</u>**

Securities and Exchange Commission

Division of Corporation Finance

Office of Life Sciences

100 F Street, NE

Washington, D.C. 20549

Attention: &nbsp;&nbsp;&nbsp;&nbsp;Jessica Dickerson

**Re:&nbsp;&nbsp;&nbsp;&nbsp;CRESCENT BIOPHARMA, INC.**

**<u>Registration Statement on Form S-1 (Registration No. 333-292600)</u>&nbsp;&nbsp;&nbsp;&nbsp;**

Ladies and Gentlemen:

In accordance with Rule 461 under the Securities Act of 1933, as amended, we hereby request acceleration of the effective date of the Registration Statement on Form S-1 (Registration No. 333-292600) (as amended, the "Registration Statement") of Crescent Biopharma, Inc. (the "Company"). We respectfully request that the Registration Statement become effective as of 4:30 p.m., Eastern Time, on January 15, 2026, or at such later time as the Company or its counsel may orally request via telephone call to the staff. Once the Registration Statement has been declared effective, please orally confirm that event with our counsel, Latham & Watkins LLP, by calling Wesley C. Holmes at (617) 948-6027.

If you have any questions regarding the foregoing, please do not hesitate to contact Peter N. Handrinos at (617) 948-6060 or Wesley C. Holmes at (617) 948-6027, of Latham & Watkins LLP. Thank you in advance for your consideration.

Very truly yours,

**CRESCENT BIOPHARMA, INC.**

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| | |
|:---|:---|
| By: | /s/ Barbara H. Bispham |
| Name: | Barbara H. Bispham |
| Title: | General Counsel |

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cc: Peter N. Handrinos, Latham & Watkins LLP <br> Wesley C. Holmes, Latham & Watkins LLP

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