# EDGAR Filing Document

**Accession Number:** 0001631134
**File Stem:** 0001104659-26-015127
**Filing Date:** 2026-2
**Character Count:** 9857
**Document Hash:** 024a5f2887c21848516dc28184ce8472
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-26-015127.hdr.sgml**: 20260213

**ACCESSION NUMBER**: 0001104659-26-015127

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20251231

**FILED AS OF DATE**: 20260213

**DATE AS OF CHANGE**: 20260213

**EFFECTIVENESS DATE**: 20260213

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Sofinnova Investments, Inc.
- **CENTRAL INDEX KEY:** 0001631134

**ORGANIZATION NAME:**
- **EIN:** 000000000

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-18774
- **FILM NUMBER:** 26631941

**BUSINESS ADDRESS:**
- **STREET 1:** 3000 Sand Hill Road
- **STREET 2:** BUILDING 3-SUITE 150
- **CITY:** Menlo Park
- **STATE:** CA
- **ZIP:** 94025
- **BUSINESS PHONE:** 650.681.8428

**MAIL ADDRESS:**
- **STREET 1:** 3000 Sand Hill Road
- **STREET 2:** BUILDING 3-SUITE 150
- **CITY:** Menlo Park
- **STATE:** CA
- **ZIP:** 94025

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Sofinnova Ventures Inc
- **DATE OF NAME CHANGE:** 20150120

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2025

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** Sofinnova Investments Inc.<br>**Address:** 3000 Sand Hill Road<br>BUILDING 3-SUITE 150<br>Menlo Park, CA 94025

**Form 13F File Number:** 028-18774

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Nathalie Auber<br>**Title:** Attorney-in-Fact<br>**Phone:** 650-681-8428

**Signature, Place, and Date of Signing:**

/s/ Nathalie Auber  Menlo Park, CA  02-13-2026<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 60

**Form 13F Information Table Value Total:** $2319284145

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 |  | 1751295 | 65567 | SH |  | SOLE |  | 65567 | 0 | 0 |
| ABBVIE INC | COM | 00287Y109 |  | 72610238 | 317783 | SH |  | SOLE |  | 317783 | 0 | 0 |
| ALCON AG | ORD SHS | H01301128 |  | 26205901 | 332520 | SH |  | SOLE |  | 332520 | 0 | 0 |
| AMYLYX PHARMACEUTICALS INC | COM | 03237H101 |  | 6367356 | 527099 | SH |  | SOLE |  | 527099 | 0 | 0 |
| ANAPTYSBIO INC | COM | 032724106 |  | 13947211 | 287690 | SH |  | SOLE |  | 287690 | 0 | 0 |
| APOGEE THERAPEUTICS INC | COM | 03770N101 |  | 40370101 | 534845 | SH |  | SOLE |  | 534845 | 0 | 0 |
| ARCUS BIOSCIENCES INC | COM | 03969F109 |  | 26134480 | 1096705 | SH |  | SOLE |  | 1096705 | 0 | 0 |
| ASTRAZENECA PLC | SPONSORED ADR | 046353108 |  | 150060465 | 1632334 | SH |  | SOLE |  | 1632334 | 0 | 0 |
| AVIDITY BIOSCIENCES INC | COM | 05370A108 |  | 53745217 | 745116 | SH |  | SOLE |  | 745116 | 0 | 0 |
| AXSOME THERAPEUTICS INC | COM | 05464T104 |  | 2240262 | 12266 | SH |  | SOLE |  | 12266 | 0 | 0 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 |  | 41430614 | 697133 | SH |  | SOLE |  | 697133 | 0 | 0 |
| BRIDGEBIO PHARMA INC | COM | 10806X102 |  | 55107068 | 720448 | SH |  | SOLE |  | 720448 | 0 | 0 |
| BRISTOL-MYERS SQUIBB CO | COM | 110122108 |  | 81610896 | 1512994 | SH |  | SOLE |  | 1512994 | 0 | 0 |
| CELCUITY INC | COM | 15102K100 |  | 29863852 | 299417 | SH |  | SOLE |  | 299417 | 0 | 0 |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 |  | 27617893 | 1104274 | SH |  | SOLE |  | 1104274 | 0 | 0 |
| CIDARA THERAPEUTICS INC | COM | 171757206 |  | 39818736 | 180265 | SH |  | SOLE |  | 180265 | 0 | 0 |
| COGENT BIOSCIENCES INC | COM | 19240Q201 |  | 70103160 | 1973625 | SH |  | SOLE |  | 1973625 | 0 | 0 |
| COMPASS THERAPEUTICS INC | COM | 20454B104 |  | 18072445 | 3365446 | SH |  | SOLE |  | 3365446 | 0 | 0 |
| DEXCOM INC | COM | 252131107 |  | 25102395 | 378219 | SH |  | SOLE |  | 378219 | 0 | 0 |
| DISC MEDICINE INC | COM | 254604101 |  | 8815304 | 111010 | SH |  | SOLE |  | 111010 | 0 | 0 |
| DYNE THERAPEUTICS INC | COM | 26818M108 |  | 44091389 | 2254161 | SH |  | SOLE |  | 2254161 | 0 | 0 |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 |  | 10864478 | 437819 | SH |  | SOLE |  | 437819 | 0 | 0 |
| ELI LILLY  CO | COM | 532457108 |  | 66256171 | 61652 | SH |  | SOLE |  | 61652 | 0 | 0 |
| ESTABLISHMENT LABS HLDGS INC | COM | G31249108 |  | 2067314 | 28366 | SH |  | SOLE |  | 28366 | 0 | 0 |
| EVOMMUNE INC | COM SHS | 30054Y107 |  | 2624838 | 153320 | SH |  | SOLE |  | 153320 | 0 | 0 |
| EXACT SCIENCES CORP | COM | 30063P105 |  | 10302551 | 101443 | SH |  | SOLE |  | 101443 | 0 | 0 |
| GE HEALTHCARE TECHNOLOGIES I | COMMON STOCK | 36266G107 |  | 13195050 | 160876 | SH |  | SOLE |  | 160876 | 0 | 0 |
| GLAUKOS CORP | COM | 377322102 |  | 32532532 | 288128 | SH |  | SOLE |  | 288128 | 0 | 0 |
| IDEAYA BIOSCIENCES INC | COM | 45166A102 |  | 30598633 | 885121 | SH |  | SOLE |  | 885121 | 0 | 0 |
| IMMATICS N.V | SHS | N44445109 |  | 36073191 | 3435542 | SH |  | SOLE |  | 3435542 | 0 | 0 |
| IMMUNOME INC | COM | 45257U108 |  | 34764886 | 1618477 | SH |  | SOLE |  | 1618477 | 0 | 0 |
| INHIBRX BIOSCIENCES INC | COM | 45720N103 |  | 35917903 | 454657 | SH |  | SOLE |  | 454657 | 0 | 0 |
| INSMED INC | COM PAR $.01 | 457669307 |  | 27289646 | 156801 | SH |  | SOLE |  | 156801 | 0 | 0 |
| INTUITIVE SURGICAL INC | COM | 46120E602 |  | 71909596 | 126968 | SH |  | SOLE |  | 126968 | 0 | 0 |
| JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 |  | 163176200 | 959860 | SH |  | SOLE |  | 959860 | 0 | 0 |
| MASIMO CORP | COM | 574795100 |  | 6008902 | 46201 | SH |  | SOLE |  | 46201 | 0 | 0 |
| MIRUM PHARMACEUTICALS INC | COM | 604749101 |  | 1824669 | 23100 | SH |  | SOLE |  | 23100 | 0 | 0 |
| NEKTAR THERAPEUTICS | COM | 640268306 |  | 18545276 | 438630 | SH |  | SOLE |  | 438630 | 0 | 0 |
| PHARVARIS N V | COM | N69605108 |  | 20678440 | 745169 | SH |  | SOLE |  | 745169 | 0 | 0 |
| PRAXIS PRECISION MEDICINES INC | COM | 74006W207 |  | 37055302 | 125722 | SH |  | SOLE |  | 125722 | 0 | 0 |
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 |  | 29050014 | 271394 | SH |  | SOLE |  | 271394 | 0 | 0 |
| ROIVANT SCIENCES LTD | SHS | G76279101 |  | 15940429 | 734582 | SH |  | SOLE |  | 734582 | 0 | 0 |
| SAVARA INC | COM | 805111101 |  | 1837763 | 304770 | SH |  | SOLE |  | 304770 | 0 | 0 |
| SOLENO THERAPEUTICS INC | COM | 834203309 |  | 574768 | 12414 | SH |  | SOLE |  | 12414 | 0 | 0 |
| SUPERNUS PHARMACEUTICALS INC | COM | 868459108 |  | 27488822 | 553095 | SH |  | SOLE |  | 553095 | 0 | 0 |
| ULTRAGENYX PHARMACEUTICAL INC | COM | 90400D108 |  | 1915900 | 83300 | SH |  | SOLE |  | 83300 | 0 | 0 |
| UNIQURE NV | SHS | N90064101 |  | 4223956 | 176513 | SH |  | SOLE |  | 176513 | 0 | 0 |
| UNITED THERAPEUTICS CORP | COM | 91307C102 |  | 76810577 | 157641 | SH |  | SOLE |  | 157641 | 0 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 |  | 74620336 | 164594 | SH |  | SOLE |  | 164594 | 0 | 0 |
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 |  | 2689094 | 158182 | SH |  | SOLE |  | 158182 | 0 | 0 |
| XENON PHARMACEUTICALS INC | COM | 98420N105 |  | 2684718 | 59900 | SH |  | SOLE |  | 59900 | 0 | 0 |
| ARRIVENT BIOPHARMA INC | COM | 04272N102 |  | 34138650 | 1696752 | SH |  | SOLE |  | 1696752 | 0 | 0 |
| BIOAGE LABS INC | COM | 09077V100 |  | 30346815 | 2293788 | SH |  | SOLE |  | 2293788 | 0 | 0 |
| BOLT BIOTHERAPEUTICS INC | COM | 097702203 |  | 753058 | 137721 | SH |  | SOLE |  | 137721 | 0 | 0 |
| IMAGENEBIO INC | COM | 45175G207 |  | 220000 | 31884 | SH |  | SOLE |  | 31884 | 0 | 0 |
| JADE BIOSCIENCES INC | COM | 008064206 |  | 1657043 | 107391 | SH |  | SOLE |  | 107391 | 0 | 0 |
| NATERA INC | COM | 632307104 |  | 355153645 | 1550280 | SH |  | SOLE |  | 1550280 | 0 | 0 |
| NEXTCURE INC | COM | 65343E207 |  | 3159460 | 222654 | SH |  | SOLE |  | 222654 | 0 | 0 |
| RAPPORT THERAPEUTICS INC | COM | 75383L102 |  | 57779739 | 1904408 | SH |  | SOLE |  | 1904408 | 0 | 0 |
| VERA THERAPEUTICS INC | CL A | 92337R101 |  | 141487502 | 2793987 | SH |  | SOLE |  | 2793987 | 0 | 0 |

---