# EDGAR Filing Document

**Accession Number:** 0002005245
**File Stem:** 0002005369-25-000014
**Filing Date:** 2025-8
**Character Count:** 15337
**Document Hash:** 7832ab9539f85aa14fece0518c993f96
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0002005369-25-000014.hdr.sgml**: 20250813

**ACCESSION NUMBER**: 0002005369-25-000014

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20250630

**FILED AS OF DATE**: 20250813

**DATE AS OF CHANGE**: 20250813

**EFFECTIVENESS DATE**: 20250813

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Siren, L.L.C.
- **CENTRAL INDEX KEY:** 0002005245

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-24464
- **FILM NUMBER:** 251209501

**BUSINESS ADDRESS:**
- **STREET 1:** 10 QUAIL ROAD
- **CITY:** GREENWICH
- **STATE:** CT
- **ZIP:** 06831
- **BUSINESS PHONE:** 212-371-1717

**MAIL ADDRESS:**
- **STREET 1:** THE INVUS GROUP, LLC
- **STREET 2:** 750 LEXINGTON AVENUE, 30TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10022

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 06-30-2025

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** Siren L.L.C.<br>**Address:** The Invus Group Llc<br>750 Lexington Avenue 30th Floor<br>New York, NY 10022

**Form 13F File Number:** 028-24464

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Raymond Debbane<br>**Title:** Managing Member<br>**Phone:** 212-371-1717

**Signature, Place, and Date of Signing:**

/s/ Raymond Debbane  New York, NY  08-13-2025<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 2

**Form 13F Information Table Entry Total:** 111

**Form 13F Information Table Value Total:** $1932435966

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

| No.   | Name                         | Form 13F File Number   |
|:---|:---|:---|
|  | Invus Financial Advisors LLC | 028-19938              |
|  | Invus Group LLC              | 028-24462              |

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| Adobe Inc | COM | 00724F101 |  | 5822931 | 15051 | SH |  | DFND | 2 | 15051 | 0 | 0 |
| Agenus Inc | COM NEW | 00847G804 |  | 4863623 | 1064250 | SH |  | DFND | 2 | 1064250 | 0 | 0 |
| Akero Therapeutics Inc | COM | 00973Y108 |  | 17003004 | 318647 | SH |  | DFND | 2 | 318647 | 0 | 0 |
| Alphabet Inc | CAP STK CL A | 02079K305 |  | 8933869 | 50703 | SH |  | DFND | 2 | 50703 | 0 | 0 |
| Amazon.com Inc | COM | 023135106 |  | 12395535 | 56500 | SH |  | DFND | 2 | 56500 | 0 | 0 |
| Apellis Pharmaceuticals Inc | COM | 03753U106 |  | 44632035 | 2578396 | SH |  | DFND | 2 | 2578396 | 0 | 0 |
| Apogee Therapeutics Inc | COM | 03770N101 |  | 25840589 | 594994 | SH |  | DFND | 2 | 594994 | 0 | 0 |
| Arcus Biosciences Inc | COM | 03969F109 |  | 13122307 | 1612077 | SH |  | DFND | 1 | 1612077 | 0 | 0 |
| Arrivent Biopharma Inc | COM | 04272N102 |  | 15239000 | 700000 | SH |  | DFND | 2 | 700000 | 0 | 0 |
| Arrowhead Pharmaceuticals Inc | COM | 04280A100 |  | 42184104 | 2669880 | SH |  | DFND | 2 | 2669880 | 0 | 0 |
| Ascendis Pharma A/S | SPONSORED ADR | 04351P101 |  | 42449762 | 245943 | SH |  | DFND | 2 | 245943 | 0 | 0 |
| Atlassian Corp | CL A | 049468101 |  | 710815 | 3500 | SH |  | DFND | 2 | 3500 | 0 | 0 |
| Avidity Biosciences Inc | COM | 05370A108 |  | 31541324 | 1110610 | SH |  | DFND | 2 | 1110610 | 0 | 0 |
| BeOne Medicines AG | SPONSORED ADS | 07725L102 |  | 123453279 | 509990 | SH |  | DFND | 2 | 509990 | 0 | 0 |
| Bicara Therapeutics Inc | COM | 055477103 |  | 48465642 | 5216969 | SH |  | DFND | 2 | 5216969 | 0 | 0 |
| Bicycle Therapeutics PLC | SPONSORED ADS | 088786108 |  | 13988626 | 2012752 | SH |  | DFND | 2 | 2012752 | 0 | 0 |
| BIOAGE Labs Inc | COM | 09077V100 |  | 1579337 | 382406 | SH |  | DFND | 2 | 382406 | 0 | 0 |
| Birkenstock Holding PLC | COM SHS | M2029K104 |  | 1229500 | 25000 | SH |  | DFND | 2 | 25000 | 0 | 0 |
| Black Diamond Therapeutics Inc | COM | 09203E105 |  | 2595362 | 1046517 | SH |  | DFND | 2 | 1046517 | 0 | 0 |
| Caribou Biosciences Inc | COM | 142038108 |  | 132737 | 105347 | SH |  | DFND | 2 | 105347 | 0 | 0 |
| Cartesian Therapeutics Inc | COM NEW | 816212302 |  | 5852396 | 563272 | SH |  | DFND | 2 | 563272 | 0 | 0 |
| CCC Intelligent Solutions Holdings Inc | COM | 12510Q100 |  | 470500 | 50000 | SH |  | DFND | 2 | 50000 | 0 | 0 |
| Cellebrite DI Ltd | ORDINARY SHARES | M2197Q107 |  | 960000 | 60000 | SH |  | DFND | 2 | 60000 | 0 | 0 |
| Centessa Pharmaceuticals PLC | SPONSORED ADS | 152309100 |  | 45464781 | 3460029 | SH |  | DFND | 2 | 3460029 | 0 | 0 |
| Cogent Biosciences Inc | COM | 19240Q201 |  | 6134441 | 854379 | SH |  | DFND | 2 | 854379 | 0 | 0 |
| Crinetics Pharmaceuticals Inc | COM | 22663K107 |  | 48564452 | 1688611 | SH |  | DFND | 2 | 1688611 | 0 | 0 |
| CrowdStrike Holdings Inc | CL A | 22788C105 |  | 9422235 | 18500 | SH |  | DFND | 2 | 18500 | 0 | 0 |
| Cullinan Therapeutics Inc | COM | 230031106 |  | 8986377 | 1193410 | SH |  | DFND | 2 | 1193410 | 0 | 0 |
| Cyclerion Therapeutics Inc | COM | 23255M204 |  | 338011 | 116155 | SH |  | DFND | 2 | 116155 | 0 | 0 |
| Datadog Inc | CL A COM | 23804L103 |  | 5161630 | 38425 | SH |  | DFND | 2 | 38425 | 0 | 0 |
| Deckers Outdoor Corp | COM | 243537107 |  | 206140 | 2000 | SH |  | DFND | 2 | 2000 | 0 | 0 |
| Denali Therapeutics Inc | COM | 24823R105 |  | 11492967 | 821513 | SH |  | DFND | 2 | 821513 | 0 | 0 |
| Disc Medicine Inc | COM | 254604101 |  | 58224277 | 1099401 | SH |  | DFND | 2 | 1099401 | 0 | 0 |
| Dynatrace Inc | COM NEW | 268150109 |  | 4153393 | 75229 | SH |  | DFND | 2 | 75229 | 0 | 0 |
| Dyne Therapeutics Inc | COM | 26818M108 |  | 46042880 | 4836437 | SH |  | DFND | 2 | 4836437 | 0 | 0 |
| Edgewise Therapeutics Inc | COM | 28036F105 |  | 41431507 | 3160298 | SH |  | DFND | 2 | 3160298 | 0 | 0 |
| Eledon Pharmaceuticals Inc | COM | 28617K101 |  | 1870361 | 690170 | SH |  | DFND | 2 | 690170 | 0 | 0 |
| Erasca Inc | COM | 29479A108 |  | 11121706 | 8757249 | SH |  | DFND | 2 | 8757249 | 0 | 0 |
| Foghorn Therapeutics Inc | COM | 344174107 |  | 3387384 | 720720 | SH |  | DFND | 2 | 720720 | 0 | 0 |
| Generation Bio Co | COM | 37148K100 |  | 950353 | 2968925 | SH |  | DFND | 2 | 2968925 | 0 | 0 |
| GitLab Inc | CLASS A COM | 37637K108 |  | 1578850 | 35000 | SH |  | DFND | 2 | 35000 | 0 | 0 |
| Gossamer Bio Inc | COM | 38341P102 |  | 6407031 | 5208968 | SH |  | DFND | 2 | 5208968 | 0 | 0 |
| HOOKIPA Pharma Inc | COM NEW | 43906K209 |  | 711133 | 566640 | SH |  | DFND | 2 | 566640 | 0 | 0 |
| HubSpot Inc | COM | 443573100 |  | 1669890 | 3000 | SH |  | DFND | 2 | 3000 | 0 | 0 |
| IGM Biosciences Inc | COM | 449585108 |  | 3646525 | 3255826 | SH |  | DFND | 2 | 3255826 | 0 | 0 |
| IHS Holding Limited | ORD SHS | G4701H109 |  | 13107811 | 2357520 | SH |  | DFND | 1 | 2357520 | 0 | 0 |
| Instil Bio Inc | COM NEW | 45783C200 |  | 4247924 | 203933 | SH |  | DFND | 2 | 203933 | 0 | 0 |
| IONQ Inc | COM | 46222L108 |  | 7304900 | 170000 | SH |  | DFND | 1 | 170000 | 0 | 0 |
| Ironwood Pharmaceuticals Inc | COM CL A | 46333X108 |  | 79583 | 110532 | SH |  | DFND | 2 | 110532 | 0 | 0 |
| Jfrog Ltd | ORD SHS | M6191J100 |  | 4700250 | 107116 | SH |  | DFND | 2 | 107116 | 0 | 0 |
| Kalaris Therapeutics Inc | COM | 482929106 |  | 754505 | 282586 | SH |  | DFND | 2 | 282586 | 0 | 0 |
| Ke Holdings Inc | SPONSORED ADS | 482497104 |  | 1862700 | 105000 | SH |  | DFND | 2 | 105000 | 0 | 0 |
| Korro Bio Inc | COM | 500946108 |  | 5231224 | 418833 | SH |  | DFND | 2 | 418833 | 0 | 0 |
| Kymera Therapeutics Inc | COM | 501575104 |  | 149604466 | 3428150 | SH |  | DFND | 2 | 3428150 | 0 | 0 |
| Lexeo Therapeutics Inc | COM | 52886X107 |  | 2425809 | 603435 | SH |  | DFND | 2 | 603435 | 0 | 0 |
| Lexicon Pharmaceuticals Inc | COM NEW | 528872302 |  | 36805607 | 38918903 | SH |  | DFND | 2 | 38918903 | 0 | 0 |
| Merus NV | COM | N5749R100 |  | 44892364 | 853467 | SH |  | DFND | 2 | 853467 | 0 | 0 |
| Microsoft Corp | COM | 594918104 |  | 8033172 | 16150 | SH |  | DFND | 2 | 16150 | 0 | 0 |
| MoonLake Immunotherapeutics | CLASS A ORD | 61559X104 |  | 23990202 | 508267 | SH |  | DFND | 2 | 508267 | 0 | 0 |
| Nebius Group NV | SHS CLASS A | N97284108 |  | 2821830 | 51000 | SH |  | DFND | 2 | 51000 | 0 | 0 |
| Neumora Therapeutics Inc | COM | 640979100 |  | 3195929 | 4358283 | SH |  | DFND | 2 | 4358283 | 0 | 0 |
| New Oriental Education  Technology Group Inc | SPON ADR | 647581206 |  | 3884400 | 72000 | SH |  | DFND | 2 | 72000 | 0 | 0 |
| NewAmsterdam Pharma Company NV | ORDINARY SHARES | N62509109 |  | 21627686 | 1194240 | SH |  | DFND | 2 | 1194240 | 0 | 0 |
| NVIDIA Corp | COM | 67066G104 |  | 7897130 | 49985 | SH |  | DFND | 2 | 49985 | 0 | 0 |
| Oric Pharmaceuticals Inc | COM | 68622P109 |  | 10226886 | 1007575 | SH |  | DFND | 1 | 1007575 | 0 | 0 |
| Pacira Biosciences Inc | COM | 695127100 |  | 5377500 | 225000 | SH |  | DFND | 2 | 225000 | 0 | 0 |
| Palo Alto Networks Inc | COM | 697435105 |  | 2353360 | 11500 | SH |  | DFND | 2 | 11500 | 0 | 0 |
| PDD Holdings Inc | SPONSORED ADS | 722304102 |  | 5536619 | 52901 | SH |  | DFND | 2 | 52901 | 0 | 0 |
| PG Corp | COM | 69331C108 |  | 348500 | 25000 | SH |  | DFND | 2 | 25000 | 0 | 0 |
| Primo Brands Corp | CLASS A COM SHS | 741623102 |  | 1110750 | 37500 | SH |  | DFND | 2 | 37500 | 0 | 0 |
| Procore Technologies Inc | COM | 74275K108 |  | 684200 | 10000 | SH |  | DFND | 2 | 10000 | 0 | 0 |
| ProQR Therapeutics NV | SHS EURO | N71542109 |  | 3166453 | 1552183 | SH |  | DFND | 2 | 1552183 | 0 | 0 |
| Qualcomm Inc | COM | 747525103 |  | 2229640 | 14000 | SH |  | DFND | 2 | 14000 | 0 | 0 |
| Rapport Therapeutics Inc | COM | 75383L102 |  | 4303193 | 378469 | SH |  | DFND | 2 | 378469 | 0 | 0 |
| Reddit Inc | CL A | 75734B100 |  | 301140 | 2000 | SH |  | DFND | 2 | 2000 | 0 | 0 |
| Remitly Global Inc | COM | 75960P104 |  | 8736478 | 465449 | SH |  | DFND | 1 | 465449 | 0 | 0 |
| Remitly Global Inc | COM | 75960P104 |  | 938500 | 50000 | SH |  | DFND | 2 | 50000 | 0 | 0 |
| Revolution Medicines Inc | COM | 76155X100 |  | 34536796 | 938755 | SH |  | DFND | 2 | 938755 | 0 | 0 |
| Rhythm Pharmaceuticals Inc | COM | 76243J105 |  | 25891597 | 409742 | SH |  | DFND | 2 | 409742 | 0 | 0 |
| Rocket Pharmaceuticals Inc | COM | 77313F106 |  | 1448594 | 591263 | SH |  | DFND | 2 | 591263 | 0 | 0 |
| Sagimet Biosciences Inc | COM SER A | 786700104 |  | 5522755 | 724771 | SH |  | DFND | 2 | 724771 | 0 | 0 |
| SailPoint Inc | COM | 78781J109 |  | 1143000 | 50000 | SH |  | DFND | 2 | 50000 | 0 | 0 |
| Salesforce Inc | COM | 79466L302 |  | 6162794 | 22600 | SH |  | DFND | 2 | 22600 | 0 | 0 |
| Scholar Rock Holding Corp | COM | 80706P103 |  | 327635177 | 9250005 | SH |  | DFND | 2 | 9250005 | 0 | 0 |
| Seer Inc | COM CL A | 81578P106 |  | 8560000 | 4000000 | SH |  | DFND | 2 | 4000000 | 0 | 0 |
| SEMrush Holdings Inc | CL A COM | 81686C104 |  | 1131250 | 125000 | SH |  | DFND | 2 | 125000 | 0 | 0 |
| Septerna Inc | COM | 81734D104 |  | 23280573 | 2202514 | SH |  | DFND | 2 | 2202514 | 0 | 0 |
| ServiceNow Inc | COM | 81762P102 |  | 5269938 | 5126 | SH |  | DFND | 2 | 5126 | 0 | 0 |
| Silence Therapeutics PLC | ADS | 82686Q101 |  | 16886340 | 2911438 | SH |  | DFND | 2 | 2911438 | 0 | 0 |
| Sionna Therapeutics Inc | COM | 829401108 |  | 5638750 | 325000 | SH |  | DFND | 2 | 325000 | 0 | 0 |
| Soleno Therapeutics Inc | COM | 834203309 |  | 39153913 | 467342 | SH |  | DFND | 2 | 467342 | 0 | 0 |
| Solid Biosciences Inc | COM NEW | 83422E204 |  | 36115457 | 7415905 | SH |  | DFND | 2 | 7415905 | 0 | 0 |
| Spyre Therapeutics Inc | COM NEW | 00773J202 |  | 5517912 | 368598 | SH |  | DFND | 2 | 368598 | 0 | 0 |
| Stoke Therapeutics Inc | COM | 86150R107 |  | 25507388 | 2247347 | SH |  | DFND | 2 | 2247347 | 0 | 0 |
| Taboola.com Ltd | ORD SHS | M8744T106 |  | 36488352 | 9969495 | SH |  | DFND | 1 | 9969495 | 0 | 0 |
| Taiwan Semiconductor Manufacturing Co Ltd | SPONSORED ADS | 874039100 |  | 6907945 | 30500 | SH |  | DFND | 2 | 30500 | 0 | 0 |
| Tango Therapeutics Inc | COM | 87583X109 |  | 17227848 | 3364814 | SH |  | DFND | 2 | 3364814 | 0 | 0 |
| Taysha Gene Therapies Inc | COM SHS | 877619106 |  | 25444042 | 11014737 | SH |  | DFND | 2 | 11014737 | 0 | 0 |
| Tesla Inc | COM | 88160R101 |  | 1270640 | 4000 | SH |  | DFND | 2 | 4000 | 0 | 0 |
| Tourmaline Bio Inc | COM | 89157D105 |  | 1461902 | 91426 | SH |  | DFND | 2 | 91426 | 0 | 0 |
| Trevi Therapeutics Inc | COM | 89532M101 |  | 21545198 | 3938793 | SH |  | DFND | 2 | 3938793 | 0 | 0 |
| UnitedHealth Group Inc | COM | 91324P102 |  | 1583560 | 5076 | SH |  | DFND | 2 | 5076 | 0 | 0 |
| Upstream Bio Inc | COM | 91678A107 |  | 8657181 | 788450 | SH |  | DFND | 2 | 788450 | 0 | 0 |
| Vaxcyte Inc | COM | 92243G108 |  | 9608103 | 295543 | SH |  | DFND | 2 | 295543 | 0 | 0 |
| Vera Therapeutics Inc | CL A | 92337R101 |  | 5824409 | 247216 | SH |  | DFND | 2 | 247216 | 0 | 0 |
| Vertiv Holdings Co | COM CL A | 92537N108 |  | 256820 | 2000 | SH |  | DFND | 2 | 2000 | 0 | 0 |
| Vigil Neuroscience Inc | COM | 92673K108 |  | 3268968 | 411191 | SH |  | DFND | 2 | 411191 | 0 | 0 |
| WAVE Life Sciences Ltd | SHS | Y95308105 |  | 24026093 | 3696322 | SH |  | DFND | 2 | 3696322 | 0 | 0 |
| Whitehawk Therapeutics Inc | COM | 00032Q104 |  | 3893340 | 2082000 | SH |  | DFND | 2 | 2082000 | 0 | 0 |
| Workiva Inc | COM CL A | 98139A105 |  | 1916600 | 28000 | SH |  | DFND | 2 | 28000 | 0 | 0 |
| Xenon Pharmaceuticals Inc | COM | 98420N105 |  | 25439419 | 812761 | SH |  | DFND | 2 | 812761 | 0 | 0 |

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