# EDGAR Filing Document

**Accession Number:** 0001859266
**File Stem:** 0000950142-25-003013
**Filing Date:** 2025-11
**Character Count:** 35117
**Document Hash:** 9ac404d159e581c1f53e01b5126c0973
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000950142-25-003013.hdr.sgml**: 20251117

**ACCESSION NUMBER**: 0000950142-25-003013

**CONFORMED SUBMISSION TYPE**: SCHEDULE 13D/A

**PUBLIC DOCUMENT COUNT**: 3

**FILED AS OF DATE**: 20251117

**DATE AS OF CHANGE**: 20251117

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Centessa Pharmaceuticals plc
- **CENTRAL INDEX KEY:** 0001847903
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** X0
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SCHEDULE 13D/A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-92588
- **FILM NUMBER:** 251492576

**BUSINESS ADDRESS:**
- **STREET 1:** 3RD FLOOR
- **STREET 2:** 1 ASHLEY ROAD
- **CITY:** ALTRINCHAM, CHESHIRE
- **STATE:** X0
- **ZIP:** WA14 2DT
- **BUSINESS PHONE:** 44 7391 789784

**MAIL ADDRESS:**
- **STREET 1:** 3RD FLOOR
- **STREET 2:** 1 ASHLEY ROAD
- **CITY:** ALTRINCHAM, CHESHIRE
- **STATE:** X0
- **ZIP:** WA14 2DT

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Centessa Pharmaceuticals Ltd
- **DATE OF NAME CHANGE:** 20210224
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** General Atlantic Cooperatief U.A.
- **CENTRAL INDEX KEY:** 0001859266

**ORGANIZATION NAME:**
- **EIN:** 980544370
- **STATE OF INCORPORATION:** P7
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SCHEDULE 13D/A

**BUSINESS ADDRESS:**
- **STREET 1:** RAAMPLEIN 1
- **CITY:** AMSTERDAM
- **STATE:** P7
- **ZIP:** 1016 XK
- **BUSINESS PHONE:** 212-715-4000

**MAIL ADDRESS:**
- **STREET 1:** RAAMPLEIN 1
- **CITY:** AMSTERDAM
- **STATE:** P7
- **ZIP:** 1016 XK

## Ex-99

**<u>SCHEDULE A</u>**

*Members of the GA Partnership Committee (as of the date hereof)*

---

| | | |
|:---|:---|:---|
| **Name** | **Business Address** | **Citizenship** |
| William E. Ford<br> (Chief Executive Officer) | 55 East 52nd Street<br> 33rd Floor<br> New York, New York 10055 | United States |
| Torbjorn Caesar | Royal Park, 29, Avenue de la Porte-Neuve<br> L-2227 Luxembourg | Sweden and United Kingdom |
| Gabriel Caillaux | 23 Savile Row<br> London W1S 2ET<br> United Kingdom | France |
| Martin Escobari | 55 East 52nd Street<br> 33rd Floor<br> New York, New York 10055 | Bolivia and Brazil |
| David Hodgson | 55 East 52nd Street<br> 33rd Floor<br> New York, New York 10055 | United States |
| Christopher G. Lanning | 55 East 52nd Street<br> 33rd Floor<br> New York, New York 10055 | United States |

---

## Ex-99

**EXHIBIT 1**

JOINT ACQUISITION STATEMENT

PURSUANT TO RULE 13D-1(k)(1)

The undersigned acknowledge and agree that the foregoing statement on Schedule 13D is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on Schedule 13D shall be filed on behalf of each of the undersigned without the necessity of filing additional joint acquisition statements. The undersigned acknowledge that each shall be responsible for the timely filing of such amendments, and for the completeness and accuracy of the information concerning him, her or it contained herein, but shall not be responsible for the completeness and accuracy of the information concerning the other entities or persons, except to the extent that he, she or it knows or has reason to believe that such information is accurate.

Dated as of November 17, 2025

---

| | |
|:---|:---|
| **General Atlantic Cooperatief U.A.** | **General Atlantic Cooperatief U.A.** |
| Signature: | /s/ I.M. van der Hoorn |
| Name/Title: | I.M. van der Hoorn, Director A |
| Date: | 11/17/2025 |
| Signature: | /s/ Julia Lepeltak |
| Name/Title: | Julia Lepeltak, Director B |
| Date: | 11/17/2025 |
| **General Atlantic UM B.V.** | **General Atlantic UM B.V.** |
| Signature: | /s/ I.M. van der Hoorn |
| Name/Title: | I.M. van der Hoorn, Director A |
| Date: | 11/17/2025 |
| Signature: | /s/ Julia Lepeltak |
| Name/Title: | Julia Lepeltak, Director B |
| Date: | 11/17/2025 |
| **General Atlantic Partners (Bermuda) IV, L.P.** | **General Atlantic Partners (Bermuda) IV, L.P.** |
| Signature: | /s/ Michael Gosk |
| Name/Title: | Michael Gosk, Managing Director of GAP (BERMUDA) LIMITED, the general partner of GENERAL ATLANTIC GENPAR (BERMUDA), L.P., its general partner |
| Date: | 11/17/2025 |
| **General Atlantic Partners (Bermuda) EU, L.P.** | **General Atlantic Partners (Bermuda) EU, L.P.** |
| Signature: | /s/ Michael Gosk |
| Name/Title: | Michael Gosk, Managing Director of GAP (BERMUDA) LIMITED, the general partner of GENERAL ATLANTIC GENPAR (BERMUDA), L.P., its general partner |
| Date: | 11/17/2025 |
| **General Atlantic Partners (Lux) SCSp** | **General Atlantic Partners (Lux) SCSp** |
| Signature: | /s/ Ingrid van der Hoorn |
| Name/Title: | Ingrid van der Hoorn, Manager A of GENERAL ATLANTIC (LUX) S.A R.L., the general partner of GENERAL ATLANTIC GENPAR (LUX) SCSP, its general partner |
| Date: | 11/17/2025 |
| Signature: | /s/ William Blackwell |
| Name/Title: | William Blackwell, Manager B of GENERAL ATLANTIC (LUX) S.A R.L., the general partner of GENERAL ATLANTIC GENPAR (LUX) SCSP, its general partner |
| Date: | 11/17/2025 |
| **General Atlantic GenPar (Lux) SCSp** | **General Atlantic GenPar (Lux) SCSp** |
| Signature: | /s/ Ingrid van der Hoorn |
| Name/Title: | Ingrid van der Hoorn, Manager A of GENERAL ATLANTIC (LUX) S.A R.L. |
| Date: | 11/17/2025 |
| Signature: | /s/ William Blackwell |
| Name/Title: | William Blackwell, Manager B of GENERAL ATLANTIC (LUX) S.A R.L. |
| Date: | 11/17/2025 |
| **General Atlantic (Lux) S.a r.l.** | **General Atlantic (Lux) S.a r.l.** |
| Signature: | /s/ Ingrid van der Hoorn |
| Name/Title: | Ingrid van der Hoorn, Manager A |
| Date: | 11/17/2025 |
| Signature: | /s/ William Blackwell |
| Name/Title: | William Blackwell, Manager B |
| Date: | 11/17/2025 |
| **General Atlantic GenPar (Bermuda), L.P.** | **General Atlantic GenPar (Bermuda), L.P.** |
| Signature: | /s/ Michael Gosk |
| Name/Title: | Michael Gosk, Managing Director of GAP (BERMUDA) LIMITED, its general partner |
| Date: | 11/17/2025 |
| **GAP (Bermuda) Limited** | **GAP (Bermuda) Limited** |
| Signature: | /s/ Michael Gosk |
| Name/Title: | Michael Gosk, Managing Director |
| Date: | 11/17/2025 |
| **General Atlantic Cooperatief, L.P.** | **General Atlantic Cooperatief, L.P.** |
| Signature: | /s/ Michael Gosk |
| Name/Title: | Michael Gosk, Managing Director of GAP (BERMUDA) LIMITED, its general partner |
| Date: | 11/17/2025 |

---

### UNITED STATES SECURITIES AND EXCHANGE COMMISSION
**Washington, D.C. 20549**

## SCHEDULE 13D

### Under the Securities Exchange Act of 1934

**(Amendment No. 1)**

**Centessa Pharmaceuticals plc**

*(Name of Issuer)*

**Ordinary shares, par value 0.002 GBP per share**

*(Title of Class of Securities)*

**152309100**

*(CUSIP Number)*

**Julia Lepeltak**<br>c/o General Atlantic UM B.V.<br>Prinsengracht 769 A<br>Amsterdam P7 1017 JZ<br>212-715-4000

*(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)*

**11/17/2025**

*(Date of Event Which Requires Filing of this Statement)*

| **CUSIP No.** | **152309100** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**General Atlantic Cooperatief U.A.** | Name of reporting person<br>**General Atlantic Cooperatief U.A.** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**OO** | Source of funds (See Instructions)<br>**OO** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**P7** | Citizenship or place of organization<br>**P7** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**9681818.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**9681818.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**9681818.00** | Aggregate amount beneficially owned by each reporting person<br>**9681818.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**6.6%** | Percent of class represented by amount in Row (11)<br>**6.6%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**OO** | Type of Reporting Person (See Instructions)<br>**OO** | |

---

| **CUSIP No.** | **152309100** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**General Atlantic UM B.V.** | Name of reporting person<br>**General Atlantic UM B.V.** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**OO** | Source of funds (See Instructions)<br>**OO** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**P7** | Citizenship or place of organization<br>**P7** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**9681818.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**9681818.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**9681818.00** | Aggregate amount beneficially owned by each reporting person<br>**9681818.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**6.6%** | Percent of class represented by amount in Row (11)<br>**6.6%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**OO** | Type of Reporting Person (See Instructions)<br>**OO** | |

---

| **CUSIP No.** | **152309100** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**General Atlantic Partners (Bermuda) IV, L.P.** | Name of reporting person<br>**General Atlantic Partners (Bermuda) IV, L.P.** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**OO** | Source of funds (See Instructions)<br>**OO** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**D0** | Citizenship or place of organization<br>**D0** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**9681818.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**9681818.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**9681818.00** | Aggregate amount beneficially owned by each reporting person<br>**9681818.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**6.6%** | Percent of class represented by amount in Row (11)<br>**6.6%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**PN** | Type of Reporting Person (See Instructions)<br>**PN** | |

---

| **CUSIP No.** | **152309100** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**General Atlantic Partners (Bermuda) EU, L.P.** | Name of reporting person<br>**General Atlantic Partners (Bermuda) EU, L.P.** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**OO** | Source of funds (See Instructions)<br>**OO** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**D0** | Citizenship or place of organization<br>**D0** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**9681818.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**9681818.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**9681818.00** | Aggregate amount beneficially owned by each reporting person<br>**9681818.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**6.6%** | Percent of class represented by amount in Row (11)<br>**6.6%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**PN** | Type of Reporting Person (See Instructions)<br>**PN** | |

---

| **CUSIP No.** | **152309100** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**General Atlantic Partners (Lux) SCSp** | Name of reporting person<br>**General Atlantic Partners (Lux) SCSp** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**OO** | Source of funds (See Instructions)<br>**OO** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**N4** | Citizenship or place of organization<br>**N4** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**9681818.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**9681818.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**9681818.00** | Aggregate amount beneficially owned by each reporting person<br>**9681818.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**6.6%** | Percent of class represented by amount in Row (11)<br>**6.6%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**PN** | Type of Reporting Person (See Instructions)<br>**PN** | |

---

| **CUSIP No.** | **152309100** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**General Atlantic GenPar (Lux) SCSp** | Name of reporting person<br>**General Atlantic GenPar (Lux) SCSp** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**OO** | Source of funds (See Instructions)<br>**OO** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**N4** | Citizenship or place of organization<br>**N4** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**9681818.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**9681818.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**9681818.00** | Aggregate amount beneficially owned by each reporting person<br>**9681818.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**6.6%** | Percent of class represented by amount in Row (11)<br>**6.6%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**PN** | Type of Reporting Person (See Instructions)<br>**PN** | |

---

| **CUSIP No.** | **152309100** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**General Atlantic (Lux) S.a r.l.** | Name of reporting person<br>**General Atlantic (Lux) S.a r.l.** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**OO** | Source of funds (See Instructions)<br>**OO** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**N4** | Citizenship or place of organization<br>**N4** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**9681818.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**9681818.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**9681818.00** | Aggregate amount beneficially owned by each reporting person<br>**9681818.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**6.6%** | Percent of class represented by amount in Row (11)<br>**6.6%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**CO** | Type of Reporting Person (See Instructions)<br>**CO** | |

---

| **CUSIP No.** | **152309100** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**General Atlantic GenPar (Bermuda), L.P.** | Name of reporting person<br>**General Atlantic GenPar (Bermuda), L.P.** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**OO** | Source of funds (See Instructions)<br>**OO** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**N4** | Citizenship or place of organization<br>**N4** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**9681818.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**9681818.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**9681818.00** | Aggregate amount beneficially owned by each reporting person<br>**9681818.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**6.6%** | Percent of class represented by amount in Row (11)<br>**6.6%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**PN** | Type of Reporting Person (See Instructions)<br>**PN** | |

---

| **CUSIP No.** | **152309100** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**GAP (Bermuda) Limited** | Name of reporting person<br>**GAP (Bermuda) Limited** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**OO** | Source of funds (See Instructions)<br>**OO** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**N4** | Citizenship or place of organization<br>**N4** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**9681818.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**9681818.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**9681818.00** | Aggregate amount beneficially owned by each reporting person<br>**9681818.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**6.6%** | Percent of class represented by amount in Row (11)<br>**6.6%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**CO** | Type of Reporting Person (See Instructions)<br>**CO** | |

---

| **CUSIP No.** | **152309100** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**General Atlantic Cooperatief, L.P.** | Name of reporting person<br>**General Atlantic Cooperatief, L.P.** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**OO** | Source of funds (See Instructions)<br>**OO** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**N4** | Citizenship or place of organization<br>**N4** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**9681818.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**9681818.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**9681818.00** | Aggregate amount beneficially owned by each reporting person<br>**9681818.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**6.6%** | Percent of class represented by amount in Row (11)<br>**6.6%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**PN** | Type of Reporting Person (See Instructions)<br>**PN** | |

---

**Item 1. Security and Issuer**

**(a) Title of Class of Securities:**
Ordinary shares, par value 0.002 GBP per share

**(b) Name of Issuer:**
Centessa Pharmaceuticals plc

**(c) Address of Issuer's Principal Executive Offices:**
3RD FLOOR, 1 ASHLEY ROAD, ALTRINCHAM, CHESHIRE, X0, WA14 2DT

This Amendment No. 1 to Schedule 13D (the "Statement") is being filed to amend the Statement as originally filed with the Securities and Exchange Commission on June 11, 2021, with respect to the ordinary shares, par value )0.002 GBP per share (the "ordinary shares") of Centessa Pharmaceuticals plc, a public limited company incorporated in England and Wales (the "Company"), whose principal executive offices are located at 3rd Floor, 1 Ashley Road, Altrincham, Cheshire, United Kingdom, WA14 2DT.

The Company's American depositary shares (the "ADSs"), each representing one ordinary share, are listed on the Nasdaq Global Select Market under the symbol "CNTA." Except as otherwise provided herein, each Item of the Statement remains unchanged.

**Item 4. Purpose of Transaction**

Item 4 is hereby supplemented as follows:

On November 17, 2025, GA UM entered into the 10b5-1 Plan (as defined below). The description of the 10b5-1 Plan set forth in Item 6 below is incorporated herein by reference in its entirety. The transactions contemplated by the 10b5-1 Plan will result in the disposition of securities of the Company.

**Item 5. Interest in Securities of the Issuer**

**(a)**
Item 5(a) is hereby amended and supplemented as follows:

(a) The percentages used herein are calculated based upon on an aggregate of 134,421,149 ordinary shares issued and outstanding of the Company reported to be outstanding as of September 30,  2025, as reflected in the Company's prospectus supplement, filed with the U. S. Securities and Exchange Commission (the "SEC") on November 13, 2025, and includes an aggregate amount of 13,372,093 ordinary shares issued by the Company pursuant to a public offering that closed on or about November 14, 2025. As of the date hereof, each of the Reporting Persons may be deemed to beneficially own 9,681,818 ordinary shares, or approximately 6.6% of the aggregate 147,793,242 ordinary shares. By virtue of the fact that (i) GA Coop UA owns all of GA UM's voting shares, (ii) the GA Funds contributed the capital to GA Coop UA to fund GA UM's purchases of the ADSs and may direct GA Coop UA with respect to its shares of GA UM, (iii) GAP (Bermuda) is the general partner of GenPar Bermuda and GA Coop LP, and GenPar Bermuda is the general partner of GAP Bermuda IV and GAP Bermuda EU, and is the sole shareholder of GA Sarl, (iv) GA Sarl is the general partner of GA Genpar Lux and GA Genpar Lux is the general partner of GAP Lux, and (v) the members of the GA Partnership Committee control the investment decisions of GAP (Bermuda), the Reporting Persons may be deemed to have the power to vote and direct the disposition of the ADSs owned of record by GA UM. As a result, as of the date hereof, each of the Reporting Persons may be deemed to beneficially own an aggregate of 9,681,818  ordinary shares, or approximately 6.6% of the aggregate 147,793,242 ordinary shares as described above.

**(b)**
Each of the Reporting Persons has the shared power to vote or direct the vote and the shared power to dispose or to direct the disposition of the 9,681,818 ordinary shares that may be deemed to be beneficially owned by each of them.

**(c)**
Except as otherwise described in the Statement, the Reporting Persons have not effected any transactions in the ordinary shares of the Company in the past 60 days.

**Item 6. Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer.**

Item 6 of the Statement is hereby amended and supplemented as follows:

The Reporting Persons entered into a Joint Filing Agreement on November 17, 2025 (the "Joint Filing Agreement"), pursuant to which they have agreed to file this Statement jointly in accordance with the provisions of Rule 13d-1(k)(1) under the Exchange Act. A copy of the Joint Filing Agreement is attached hereto as Exhibit 1.

On November 17, 2025, GA UM entered into a new 10b5-1 plan (the "10b5-1 Plan") with BTIG, LLC ("BTIG"). Pursuant to the 10b5-1 Plan, BTIG may sell up to 3,500,000 ADSs on behalf of GA UM. The 10b5-1 Plan will terminate on the earlier of December 17, 2026, the date on which 3,500,000 ADSs have been sold under the 10b5-1 Plan and the date the 10b5-1 Plan is otherwise terminated.

### SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** General Atlantic Cooperatief U.A.

**Signature:** /s/ I.M. van der Hoorn

**Name/Title:** I.M. van der Hoorn, Director A

**Date:** 11/17/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** General Atlantic UM B.V.

**Signature:** /s/ I.M. van der Hoorn

**Name/Title:** I.M. van der Hoorn, Director A

**Date:** 11/17/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** General Atlantic Partners (Bermuda) IV, L.P.

**Signature:** /s/ Michael Gosk

**Name/Title:** Michael Gosk, Managing Director of GAP (BERMUDA) LIMITED, the general partner of GENERAL ATLANTIC GENPAR (BERMUDA), L.P., its general partner

**Date:** 11/17/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** General Atlantic Partners (Bermuda) EU, L.P.

**Signature:** /s/ Michael Gosk

**Name/Title:** Michael Gosk, Managing Director of GAP (BERMUDA) LIMITED, the general partner of GENERAL ATLANTIC GENPAR (BERMUDA), L.P., its general partner

**Date:** 11/17/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** General Atlantic Partners (Lux) SCSp

**Signature:** /s/ Ingrid van der Hoorn

**Name/Title:** Ingrid van der Hoorn, Manager A of GENERAL ATLANTIC (LUX) S.A R.L., the general partner of GENERAL ATLANTIC GENPAR (LUX) SCSP, its general partner

**Date:** 11/17/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** General Atlantic GenPar (Lux) SCSp

**Signature:** /s/ Ingrid van der Hoorn

**Name/Title:** Ingrid van der Hoorn, Manager A of GENERAL ATLANTIC (LUX) S.A R.L.

**Date:** 11/17/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** General Atlantic (Lux) S.a r.l.

**Signature:** /s/ Ingrid van der Hoorn

**Name/Title:** Ingrid van der Hoorn, Manager A

**Date:** 11/17/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** General Atlantic GenPar (Bermuda), L.P.

**Signature:** /s/ Michael Gosk

**Name/Title:** Michael Gosk, Managing Director of GAP (BERMUDA) LIMITED, its general partner

**Date:** 11/17/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** GAP (Bermuda) Limited

**Signature:** /s/ Michael Gosk

**Name/Title:** Michael Gosk, Managing Director

**Date:** 11/17/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** General Atlantic Cooperatief, L.P.

**Signature:** /s/ Michael Gosk

**Name/Title:** Michael Gosk, Managing Director of GAP (BERMUDA) LIMITED, its general partner

**Date:** 11/17/2025