# EDGAR Filing Document

**Accession Number:** 0001761612
**File Stem:** 0001104659-25-076811
**Filing Date:** 2025-8
**Character Count:** 3055
**Document Hash:** fc245e6c20a0d775bc1d9a18f08304df
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-25-076811.hdr.sgml**: 20250912

**ACCESSION NUMBER**: 0001104659-25-076811

**CONFORMED SUBMISSION TYPE**: CORRESP

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20250812

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** BICYCLE THERAPEUTICS PLC
- **CENTRAL INDEX KEY:** 0001761612
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** X0
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** CORRESP

**BUSINESS ADDRESS:**
- **STREET 1:** BLOCKS A & B, PORTWAY BUILDING
- **STREET 2:** GRANTA PARK, GREAT ABINGTON
- **CITY:** CAMBRIDGE
- **STATE:** X0
- **ZIP:** CB21 6GS
- **BUSINESS PHONE:** 011441223261503

**MAIL ADDRESS:**
- **STREET 1:** BLOCKS A & B, PORTWAY BUILDING
- **STREET 2:** GRANTA PARK, GREAT ABINGTON
- **CITY:** CAMBRIDGE
- **STATE:** X0
- **ZIP:** CB21 6GS

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** BICYCLE THERAPEUTICS plc
- **DATE OF NAME CHANGE:** 20190530

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** BICYCLE THERAPEUTICS Ltd
- **DATE OF NAME CHANGE:** 20181212

**Bicycle Therapeutics plc**

Blocks A & B, Portway Building

Granta Park Great Abington, Cambridge CB21 6GS

United Kingdom

August 12, 2025

Via Edgar

United States Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attn: Jessica Dickerson

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| | | | |
|:---|:---|:---|:---|
| **RE:** | **Bicycle Therapeutics plc** | **Bicycle Therapeutics plc** | **Bicycle Therapeutics plc** |
|  | **Registration Statement on Form S-3** | **Registration Statement on Form S-3** | **Registration Statement on Form S-3** |
|  | **File No.** **333-289423** | **File No.** **333-289423** | **File No.** **333-289423** |
|  | **Acceleration Request** | **Acceleration Request** | **Acceleration Request** |
|  |  | **Requested Date:** | **August 14, 2025** |
|  |  | **Requested Time:** | **4:00 p.m. Eastern Time** |

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Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Exchange Act of 1933, as amended, the undersigned registrant hereby requests that the Securities and Exchange Commission take appropriate action to cause the above-referenced Registration Statement on Form S-3 (File No. 333-289423) (the "***Registration Statement***") to become effective at 4:00 p.m. Eastern Time on Thursday, August 14, 2025, or as soon thereafter as is practicable.

Once the Registration Statement has been declared effective, please orally confirm that event with Jaime L. Chase of Cooley LLP, counsel to the registrant, at (202) 728-7096.

[*Signature page follows*]

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| | |
|:---|:---|
| Sincerely, | Sincerely, |
| **Bicycle Therapeutics plc** | **Bicycle Therapeutics plc** |
| By: | /s/ Alethia Young |
|  | Alethia Young |
|  | Chief Financial Officer |
| cc: | Kevin Lee, Chief Executive Officer, Bicycle Therapeutics plc |
|  | Laura A. Berezin, Cooley LLP |
|  | Jaime L. Chase, Cooley LLP |

---