# EDGAR Filing Document

**Accession Number:** 0001655759
**File Stem:** 0000935836-25-000426
**Filing Date:** 2025-6
**Character Count:** 31535
**Document Hash:** 99e57435ca8a24f12c1f1fcb65235792
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000935836-25-000426.hdr.sgml**: 20250616

**ACCESSION NUMBER**: 0000935836-25-000426

**CONFORMED SUBMISSION TYPE**: SCHEDULE 13D

**PUBLIC DOCUMENT COUNT**: 2

**FILED AS OF DATE**: 20250616

**DATE AS OF CHANGE**: 20250616

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** ARVINAS, INC.
- **CENTRAL INDEX KEY:** 0001655759
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 472566120
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SCHEDULE 13D
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-90647
- **FILM NUMBER:** 251051341

**BUSINESS ADDRESS:**
- **STREET 1:** 395 WINCHESTER AVE
- **STREET 2:** 5 SCIENCE PARK
- **CITY:** NEW HAVEN
- **STATE:** CT
- **ZIP:** 06511
- **BUSINESS PHONE:** 203-535-1456

**MAIL ADDRESS:**
- **STREET 1:** 395 WINCHESTER AVE
- **STREET 2:** 5 SCIENCE PARK
- **CITY:** NEW HAVEN
- **STATE:** CT
- **ZIP:** 06511

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ARVINAS INC.
- **DATE OF NAME CHANGE:** 20181001

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ARVINAS HOLDING COMPANY, LLC
- **DATE OF NAME CHANGE:** 20151015
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Logos Global Management LP
- **CENTRAL INDEX KEY:** 0001792126

**ORGANIZATION NAME:**
- **EIN:** 833997742
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SCHEDULE 13D

**BUSINESS ADDRESS:**
- **STREET 1:** 1 LETTERMAN DRIVE
- **STREET 2:** BLDG C, SUITE C3-350
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94129
- **BUSINESS PHONE:** 4158014660

**MAIL ADDRESS:**
- **STREET 1:** 1 LETTERMAN DRIVE
- **STREET 2:** BLDG C, SUITE C3-350
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94129

## Exhibit 99.1

EXHIBIT 99.1

AGREEMENT REGARDING JOINT FILING

OF STATEMENT ON SCHEDULE 13D OR 13G

The undersigned agree to file jointly with the Securities and Exchange Commission (the "SEC") any and all statements on Schedule 13D or Schedule 13G or Forms 3, 4 or 5(and any amendments or supplements thereto) required under section 13(d) and 16(a) of the Securities Exchange Act of 1934, as amended, in connection with purchases by the undersigned of the securities of any issuer. For that purpose, the undersigned hereby constitute and appoint Logos Global Management LP, a Delaware limited partnership, as their true and lawful agent and attorney-in-fact, with full power and authority for and on behalf of the undersigned to prepare or cause to be prepared, sign, file with the SEC and furnish to any other person all certificates, instruments, agreements and documents necessary to comply with section 13(d) and section 16(a) of the Securities Exchange Act of 1934, as amended, in connection with said purchases, and to do and perform every act necessary and proper to be done incident to the exercise of the foregoing power, as fully as the undersigned might or could do if personally present.

Dated: June 16, 2025

---

| | |
|:---|:---|
| &nbsp;&nbsp; **Logos Global Management LP**<br>By: <u>/s/ *Arsani William*</u> <br> Arsani William, Managing Partner | &nbsp;&nbsp; **Logos Global Master Fund LP**<br>By: <u>/s/ *Arsani William*</u> <br> Arsani William, Managing Member of Logos GP LLC, General Partner of Logos Global Master Fund LP<br>|
| &nbsp;&nbsp; **Logos Global Management GP LLC**<br>By: <u>/s/ *Arsani William*</u> <br> Arsani William, Managing Member | &nbsp;&nbsp; **Logos GP LLC**<br>By: <u>/s/ *Arsani William*</u> <br> Arsani William, Managing Member<br>|
| &nbsp;&nbsp; **Logos Opportunities IV GP LLC**<br>By: <u>/s/ *Arsani William*</u> <br> Arsani William, Managing Member | &nbsp;&nbsp; **Logos Opportunities Fund IV LP**<br> By: <u>/s/ *Arsani William*</u> <br> Arsani William, Managing Member of Logos Opportunities IV GP LLC, General Partner of Logos Opportunities Fund IV LP |
| &nbsp;&nbsp; <br><u>/s/ *Arsani William*</u> **<br> Arsani William**<br>| &nbsp;&nbsp; <br><u>/s/ *Graham Walmsley*</u> **<br> Graham Walmsley** |

---

### UNITED STATES SECURITIES AND EXCHANGE COMMISSION
**Washington, D.C. 20549**

## SCHEDULE 13D

### Under the Securities Exchange Act of 1934

**ARVINAS, INC.**

*(Name of Issuer)*

**Common Stock ("Stock")**

*(Title of Class of Securities)*

**04335A105**

*(CUSIP Number)*

**Derek Gould**<br>Logos Global Management LP<br>One Letterman Dr. Bldg C, Suite C3-350<br>San Francisco CA 94129<br>(415) 801-4660

*(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)*

**06/09/2025**

*(Date of Event Which Requires Filing of this Statement)*

| **CUSIP No.** | **04335A105** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**Logos Global Management LP** | Name of reporting person<br>**Logos Global Management LP** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[ ] (a)<br>[x] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[ ] (a)<br>[x] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**4800000.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**4800000.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**4800000.00** | Aggregate amount beneficially owned by each reporting person<br>**4800000.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**6.4%** | Percent of class represented by amount in Row (11)<br>**6.4%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**IA** | Type of Reporting Person (See Instructions)<br>**IA** | |

---

**Comment for Reporting Person:** Includes 15,000 call options listed on Nasdaq exercisable within 60 days for delivery of 1,500,000 shares.

| **CUSIP No.** | **04335A105** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**Logos Global Management GP LLC** | Name of reporting person<br>**Logos Global Management GP LLC** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[ ] (a)<br>[x] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[ ] (a)<br>[x] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**4800000.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**4800000.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**4800000.00** | Aggregate amount beneficially owned by each reporting person<br>**4800000.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**6.4%** | Percent of class represented by amount in Row (11)<br>**6.4%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**HC** | Type of Reporting Person (See Instructions)<br>**HC** | |

---

**Comment for Reporting Person:** Includes 15,000 call options listed on Nasdaq exercisable within 60 days for delivery of 1,500,000 shares.

| **CUSIP No.** | **04335A105** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**Logos Global Master Fund LP** | Name of reporting person<br>**Logos Global Master Fund LP** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[ ] (a)<br>[x] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[ ] (a)<br>[x] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**WC** | Source of funds (See Instructions)<br>**WC** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**3500000.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**3500000.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**3500000.00** | Aggregate amount beneficially owned by each reporting person<br>**3500000.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**4.7%** | Percent of class represented by amount in Row (11)<br>**4.7%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**PN** | Type of Reporting Person (See Instructions)<br>**PN** | |

---

**Comment for Reporting Person:** Includes 15,000 call options listed on Nasdaq exercisable within 60 days for delivery of 1,500,000 shares.

| **CUSIP No.** | **04335A105** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**Logos GP LLC** | Name of reporting person<br>**Logos GP LLC** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[ ] (a)<br>[x] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[ ] (a)<br>[x] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**3500000.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**3500000.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**3500000.00** | Aggregate amount beneficially owned by each reporting person<br>**3500000.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**4.7%** | Percent of class represented by amount in Row (11)<br>**4.7%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**HC** | Type of Reporting Person (See Instructions)<br>**HC** | |

---

**Comment for Reporting Person:** Includes 15,000 call options listed on Nasdaq exercisable within 60 days for delivery of 1,500,000 shares.

| **CUSIP No.** | **04335A105** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**Logos Opportunities Fund IV GP LLC** | Name of reporting person<br>**Logos Opportunities Fund IV GP LLC** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[ ] (a)<br>[x] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[ ] (a)<br>[x] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**1300000.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**1300000.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**1300000.00** | Aggregate amount beneficially owned by each reporting person<br>**1300000.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**1.7%** | Percent of class represented by amount in Row (11)<br>**1.7%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**HC** | Type of Reporting Person (See Instructions)<br>**HC** | |

---

| **CUSIP No.** | **04335A105** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**Logos Opportunities Fund IV LP** | Name of reporting person<br>**Logos Opportunities Fund IV LP** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[ ] (a)<br>[x] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[ ] (a)<br>[x] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**WC** | Source of funds (See Instructions)<br>**WC** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**1300000.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**1300000.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**1300000.00** | Aggregate amount beneficially owned by each reporting person<br>**1300000.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**1.7%** | Percent of class represented by amount in Row (11)<br>**1.7%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**PN** | Type of Reporting Person (See Instructions)<br>**PN** | |

---

| **CUSIP No.** | **04335A105** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**Arsani William** | Name of reporting person<br>**Arsani William** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[ ] (a)<br>[x] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[ ] (a)<br>[x] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**X1** | Citizenship or place of organization<br>**X1** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**4800000.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**4800000.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**4800000.00** | Aggregate amount beneficially owned by each reporting person<br>**4800000.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**6.4%** | Percent of class represented by amount in Row (11)<br>**6.4%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**IN** | Type of Reporting Person (See Instructions)<br>**IN** | |

---

**Comment for Reporting Person:** Includes 15,000 call options listed on Nasdaq exercisable within 60 days for delivery of 1,500,000 shares.

| **CUSIP No.** | **04335A105** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**Graham Walmsley** | Name of reporting person<br>**Graham Walmsley** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[ ] (a)<br>[x] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[ ] (a)<br>[x] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**X1** | Citizenship or place of organization<br>**X1** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**1300000.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**1300000.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**1300000.00** | Aggregate amount beneficially owned by each reporting person<br>**1300000.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**1.7%** | Percent of class represented by amount in Row (11)<br>**1.7%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**IN** | Type of Reporting Person (See Instructions)<br>**IN** | |

---

**Item 1. Security and Issuer**

**(a) Title of Class of Securities:**
Common Stock ("Stock")

**(b) Name of Issuer:**
ARVINAS, INC.

**(c) Address of Issuer's Principal Executive Offices:**
395 WINCHESTER AVE, 5 Science Park, New Haven, CT, 06511

**Item 4. Purpose of Transaction**

The reporting persons acquired the securities for investment purposes. The reporting persons will routinely monitor the Issuer regarding a wide variety of factors that affect their investment considerations, including, current and anticipated future trading prices of the Stock and other securities, the Issuer's operations, assets, prospects, financial position, and business development, Issuer's management, Issuer-related competitive and strategic matters, general economic, financial market and industry conditions, and other investment considerations.  Depending on their evaluation of various factors, the reporting persons may take such actions regarding their holdings of the Issuer's securities as they deem appropriate in light of circumstances existing from time to time. Such actions may include purchasing additional securities in the open market, through privately negotiated transactions with third parties or otherwise, and selling at any time, in the open market, through privately negotiated transactions with third parties or otherwise, all or part of the securities now owned or hereafter acquired by any of them.  The reporting persons also may from time to time enter into or unwind hedging or other derivative transactions with respect to the Stock or pledge their interests in the Stock to obtain liquidity. In addition, from time to time the reporting persons and their representatives and advisers may communicate with other stockholders, industry participants and other interested parties about the Issuer.

On June 10, 2025, the Reporting Persons sent an email to members of the board of directors of the Issuer respectfully recommending a strategic reset of the company's direction and structure. Specifically, the letter urged the board to consider a special distribution to stockholders, to refrain from further investment in the early-stage pipeline, and to adopt a leaner operating model focused on preserving cash. In addition, we believe that the company should not move forward independently on its lead asset absent the involvement of a committed strategic partner.  Except with respect to the foregoing, the reporting persons have no present plan or proposal that relates to or would result in any of the actions specified in clauses (a) through (j) of Item 4 of Schedule 13D of the Act.  However, the reporting persons may recommend additional actions to the Issuer's management, board of directors and stockholders. Any such actions could involve one or more of the events referred to in clauses (a) through (j) of Item 4 of Schedule 13D, including, potentially, one or more mergers, consolidations, sales or acquisitions of assets, change in control, issuances, purchases, dispositions or pledges of securities or other changes in capitalization.

**Item 5. Interest in Securities of the Issuer**

**(a)**
Aggregate number of shares beneficially owned by the reporting persons:

Logos Global: 4,800,000
Logos Global GP: 4,800,000
Global Fund: 3,500,000
Logos GP: 3,500,000
Logos Opportunities GP: 1,300,000
Opportunities Fund: 1,300,000
Arsani William: 4,800,000
Graham Walmsley: 1,300,000

Aggregate percentage of the class of Stock beneficially owned by the reporting persons:

Logos Global: 6.4%
Logos Global GP: 6.4%
Global Fund: 4.7%
Logos GP: 4.7%
Logos Opportunities GP: 1.7%
Opportunities Fund: 1.7%
Arsani William: 6.4%
Graham Walmsley: 1.7%

**(b)**
Number of shares as to which the each reporting person has:

(i)  Sole power to vote or to direct the vote:

Logos Global: 0
Logos Global GP: 0
Global Fund: 0
Logos GP: 0
Logos Opportunities GP: 0
Opportunities Fund: 0
Arsani William: 0
Graham Walmsley: 0

(ii)  Shared power to vote or to direct the vote:

Logos Global: 4,800,000
Logos Global GP: 4,800,000
Global Fund: 3,500,000
Logos GP: 3,500,000
Logos Opportunities GP: 1,300,000
Opportunities Fund: 1,300,000
Arsani William: 4,800,000
Graham Walmsley: 1,300,000

(iii)  Sole power to dispose or to direct the disposition of:

Logos Global: 0
Logos Global GP: 0
Global Fund: 0
Logos GP: 0
Logos Opportunities GP: 0
Opportunities Fund: 0
Arsani William: 0
Graham Walmsley: 0

(iv)  Shared power to dispose or to direct the disposition of:
Logos Global: 4,800,000
Logos Global GP: 4,800,000
Global Fund: 3,500,000
Logos GP: 3,500,000
Logos Opportunities GP: 1,300,000
Opportunities Fund: 1,300,000
Arsani William: 4,800,000
Graham Walmsley: 1,300,000

**(c)**
The reporting persons engaged in the following transactions in the Issuer's securities in the 60 days preceding the date of this Schedule 13D. All transactions were effectuated in the open market through a broker. The price reported in the Trade Price column is a weighted average price if a price range is indicated in the Price Range column. Where a weighted average price is reported, those shares of Common Stock were purchased (or sold) in multiple transactions.

Fund                            Security               Trade Date     Quantity*       Trade Price    Price Range
Global Fund                Common Stock    5/01/25          316,202         $6.4704         6.25-6.60
Global Fund                Common Stock    5/01/25          (16.602)         $7.1941
Global Fund                Common Stock    5/02/25          850,000         $7.4010
Global Fund                Call Option          5/02/25            15,000**       $2.4792
Global Fund                Common Stock    5/05/25            50,000         $7.5171
Global Fund                Common Stock    5/08/25          100,000         $6.8757
Global Fund                Common Stock    5/12/25            50,000         $6.8934
Global Fund                Common Stock    5/16/25            25,000         $6.4935
Global Fund                Common Stock    5/20/25            25,000         $6.6060
Global Fund                Common Stock    5/22/25          100,000         $6.4227
Global Fund                Common Stock    5/29/25          250,000         $7.4657         7.3783-7.5255
Global Fund                Common Stock    5/30/25          100,000         $7.1995         7.1661-7.2328
Global Fund                Common Stock    6/02/25          150,000         $7.1888         6.9998-7.3355
Global Fund                Common Stock    6/03/25          100,000         $7.3225
Global Fund                Common Stock    6/06/25             50,000        $7.2967
Global Fund                Common Stock    6/06/25          (150,000)       $7.2500
Opportunities Fund     Common Stock   6/09/25            945,119        $7.6536         7.4900-7.7550
Opportunities Fund     Common Stock   6/10/25            354,881        $7.9850         7.8500-8.0760

*Quantity Purchased (Sold)
** Represents 15,000 call options listed on Nasdaq exercisable within 60 days for delivery of 1,500,000 shares.

**Item 6. Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer.**

Logos Global is the investment adviser to its clients pursuant to investment management agreements or limited partnership agreements providing to Logos Global the authority, among other things, to invest the funds of such clients in Stock, to vote and dispose of Stock and to file this statement on behalf of such clients. Pursuant to such limited partnership agreements, Logos Global and its affiliates are entitled to allocations based on assets under management and realized and unrealized gains.  Pursuant to such investment management agreements, Logos Global is entitled to fees based on assets under management and realized and unrealized gains.

### SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** Logos Global Management LP

**Signature:** /s/ Arsani William

**Name/Title:** Arsani William. Managing Partner

**Date:** 06/16/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** Logos Global Management GP LLC

**Signature:** /s/ Arsani William

**Name/Title:** Arsani William, Managing Member

**Date:** 06/16/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** Logos Global Master Fund LP

**Signature:** /s/ Arsani William

**Name/Title:** Arsani William, Managing Member

**Date:** 06/15/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** Logos GP LLC

**Signature:** /s/ Arsani William

**Name/Title:** Arsani William, Managing Member

**Date:** 06/16/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** Logos Opportunities Fund IV GP LLC

**Signature:** /s/ Arsani Willliam

**Name/Title:** Arsani William, Managing Member

**Date:** 06/16/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** Logos Opportunities Fund IV LP

**Signature:** /s/ Arsani William

**Name/Title:** Arsani William, Managing Member of Logos Opportunities IV GP LLC, General Partner of Logos Opportunities Fund IV LP

**Date:** 06/16/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** Arsani William

**Signature:** /s/ Arsani William

**Name/Title:** Arsani William, Reporting Person

**Date:** 06/16/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** Graham Walmsley

**Signature:** /s/ Graham Walmsley

**Name/Title:** Graham Walsle, Reporting Person

**Date:** 06/16/2025