# EDGAR Filing Document

**Accession Number:** 0001434868
**File Stem:** 0001628280-25-040152
**Filing Date:** 2025-8
**Character Count:** 34069
**Document Hash:** 70d1ae388cf1a2b1d8a4b60899e32140
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001628280-25-040152.hdr.sgml**: 20250813

**ACCESSION NUMBER**: 0001628280-25-040152

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 14

**REFERENCES 429**: 333-265247

**REFERENCES 429**: 333-273555

**REFERENCES 429**: 333-281486

**FILED AS OF DATE**: 20250813

**DATE AS OF CHANGE**: 20250813

**EFFECTIVENESS DATE**: 20250813

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Esperion Therapeutics, Inc.
- **CENTRAL INDEX KEY:** 0001434868
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-289575
- **FILM NUMBER:** 251211928

**BUSINESS ADDRESS:**
- **STREET 1:** 3891 RANCHERO DRIVE, SUITE 150
- **CITY:** ANN ARBOR
- **STATE:** MI
- **ZIP:** 48108
- **BUSINESS PHONE:** 734-887-3903

**MAIL ADDRESS:**
- **STREET 1:** 3891 RANCHERO DRIVE, SUITE 150
- **CITY:** ANN ARBOR
- **STATE:** MI
- **ZIP:** 48108

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** HDL THERAPEUTICS INC
- **DATE OF NAME CHANGE:** 20080513

**As filed with the Securities and Exchange Commission on August 13, 2025**

**Registration No. 333-** 

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**WASHINGTON, D.C. 20549**

**FORM S-8**

**REGISTRATION STATEMENT UNDER**

**THE SECURITIES ACT OF 1933**

**ESPERION THERAPEUTICS, INC.**

(Exact Name of Registrant as Specified in its Charter)

---

| | |
|:---|:---|
| **Delaware** | **26-1870780** |
| (State or Other Jurisdiction of Incorporation or Organization) | (I.R.S. Employer Identification No.) |

---

**Esperion Therapeutics, Inc.**

**3891 Ranchero Drive, Suite 150**

**Ann Arbor, MI 48108**

(Address of Principal Executive Offices)

**Esperion Therapeutics, Inc. 2022 Stock Option and Incentive Plan, as amended**

(Full Title of the Plans)

**Sheldon L. Koenig**

**President and Chief Executive Officer**

**Esperion Therapeutics, Inc.**

**3891 Ranchero Drive, Suite 150**

**Ann Arbor, MI 48108**

(Name and Address of Agent For Service)

**(734) 887-3903**

(Telephone Number, Including Area Code, of Agent For Service)

**Copy to:**

**Mitchell S. Bloom, Esq.**

**Adam V. Johnson, Esq.**

**Goodwin Procter LLP**

**100 Northern Avenue**

**Boston, Massachusetts 02210**

**(617) 570-1000**

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☐ | Accelerated filer  | ☒ |
| Non-accelerated filer  | ☐ | Smaller reporting company | ☐ |
| | | Emerging growth company | ☐ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

------

**EXPLANATORY NOTE**

This Registration Statement on Form S-8 (this "Registration Statement") registers additional shares of Common Stock, par value $0.001 per share ("Common Stock"), of Esperion Therapeutics, Inc. (the "Registrant") under the Registrant's 2022 Stock Option and Incentive Plan, as amended (the "Option Plan"). On May 29, 2025, the stockholders of the Registrant approved an amendment to the Option Plan, pursuant to which the number of shares of Common Stock reserved and available for issuance under the Option Plan increased by 6,250,000 shares. This Registration Statement registers these additional 6,250,000 shares of Common Stock. The additional shares are of the same class as other securities relating to the Option Plan for which the Registrant's registration statements on Form S-8 (Registration No. 333-265247, Registration No. 333-273555 and Registration No. 333-281486) filed with the Securities and Exchange Commission (the "SEC") on May 26, 2022, August 1, 2023, and August 12, 2024, respectively, are effective. The information contained in the Registrant's registration statements on Form S-8 (Registration No. 333-265247, Registration No. 333-273555, and Registration No. 333-281486) is hereby incorporated by reference pursuant to General Instruction E, except for "Item 8. Exhibits."

**PART II**

**INFORMATION REQUIRED IN THE REGISTRATION STATEMENT**

---

| | |
|:---|:---|
| **Item 8.** | **Exhibits.** |

---

See the Exhibit Index on the page immediately preceding the exhibits for a list of exhibits filed as part of this Registration Statement, which Exhibit Index is incorporated herein by reference.

------

**EXHIBIT INDEX**

---

| | |
|:---|:---|
| **Exhibit No.** | **Description** |
| <u>[4.1](https://www.sec.gov/Archives/edgar/data/1434868/000104746913006896/a2215641zex-4_1.htm)</u> | <u>[Specimen](https://www.sec.gov/Archives/edgar/data/1434868/000104746913006896/a2215641zex-4_1.htm)[C](https://www.sec.gov/Archives/edgar/data/1434868/000104746913006896/a2215641zex-4_1.htm)[ommon](https://www.sec.gov/Archives/edgar/data/1434868/000104746913006896/a2215641zex-4_1.htm)[S](https://www.sec.gov/Archives/edgar/data/1434868/000104746913006896/a2215641zex-4_1.htm)[tock](https://www.sec.gov/Archives/edgar/data/1434868/000104746913006896/a2215641zex-4_1.htm)[C](https://www.sec.gov/Archives/edgar/data/1434868/000104746913006896/a2215641zex-4_1.htm)[ertificate (incorporated by reference to Exhibit 4.1 to the Registrant's Registration Statement on Form S-1, as amended (File No. 333-188595) filed on June 12, 2013).](https://www.sec.gov/Archives/edgar/data/1434868/000104746913006896/a2215641zex-4_1.htm)</u> |
| <u>[4.2](https://www.sec.gov/Archives/edgar/data/1434868/000104746913006896/a2215641zex-3_2.htm)</u> | <u>[Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.2 to the Registrant's Registration Statement on Form S-1, as amended (File No. 333-188595) filed on June 12, 2013).](https://www.sec.gov/Archives/edgar/data/1434868/000104746913006896/a2215641zex-3_2.htm)</u> |
| <u>[4.3](https://www.sec.gov/Archives/edgar/data/1434868/000162828022015488/exhibit31.htm)</u> | <u>[Certificate of Amendment to Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K filed on May 26, 2022)](https://www.sec.gov/Archives/edgar/data/1434868/000162828022015488/exhibit31.htm)</u> |
| <u>[4.4](https://www.sec.gov/Archives/edgar/data/1434868/000162828022025245/exhibit31certificateofvali.htm)</u> | <u>[Certificate of Validation dated September 20, 2022 relating to Certificate of Amendment to the Amended and Restated Certificate of Incorporation of the Registrant dated May 26, 2022 (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K filed on September 20, 2022)](https://www.sec.gov/Archives/edgar/data/1434868/000162828022025245/exhibit31certificateofvali.htm)</u> |
| <u>[4.5](https://www.sec.gov/Archives/edgar/data/1434868/000162828023022276/exhibit3162023.htm)</u> | <u>[Certificate of Amendment No. 2 to Amended and Restated Certificate of Incorporation of the](https://www.sec.gov/Archives/edgar/data/1434868/000162828023022276/exhibit3162023.htm)[R](https://www.sec.gov/Archives/edgar/data/1434868/000162828023022276/exhibit3162023.htm)[egistrant (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K filed on June 15, 2023)](https://www.sec.gov/Archives/edgar/data/1434868/000162828023022276/exhibit3162023.htm)</u> |
| <u>[4.6](https://www.sec.gov/Archives/edgar/data/1434868/000162828021008918/ex31-secondamendedandresta.htm)</u> | <u>[Second Amended and Restated Bylaws of the Registrant dated April 29, 2021 (incorporated by reference to Exhibit 3.1 to the Registrant's Quarterly Report on Form 10-Q (File No. 001-35986) filed on May 4, 2021)](https://www.sec.gov/Archives/edgar/data/1434868/000162828021008918/ex31-secondamendedandresta.htm)</u> |
| <u>[4.7](https://www.sec.gov/Archives/edgar/data/1434868/000104746913006083/a2214660zex-4_3.htm)</u> | <u>[Form of Warrant to Purchase Preferred Stock dated September 4, 2012 (incorporated by reference to Exhibit 4.3 to the Registrant's Registration Statement on Form S-1, as amended (File No. 333-188595) filed on May 14, 2013).](https://www.sec.gov/Archives/edgar/data/1434868/000104746913006083/a2214660zex-4_3.htm)</u> |
| <u>[4.8](https://www.sec.gov/Archives/edgar/data/1434868/000110465923035634/tm2310183d1_ex10-2.htm)</u> | <u>[Form of Warrant Amendment Agreement (incorporated by reference to Exhibit 10.2 to the Registrant's Quarterly Report on Form 10-Q (File No. 001-35986) filed on May 9, 2023).](https://www.sec.gov/Archives/edgar/data/1434868/000110465923035634/tm2310183d1_ex10-2.htm)</u> |
| <u>[4.](https://www.sec.gov/Archives/edgar/data/1434868/000104746913006083/a2214660zex-4_4.htm)[9](https://www.sec.gov/Archives/edgar/data/1434868/000104746913006083/a2214660zex-4_4.htm)</u> | <u>[Investor Rights Agreement by and between the Registrant and certain of its stockholders dated April 28, 2008 (incorporated by reference to Exhibit 4.4 to the Registrant's Registration Statement on Form S-1, as amended (File No. 333-188595) filed on May 14, 2013).](https://www.sec.gov/Archives/edgar/data/1434868/000104746913006083/a2214660zex-4_4.htm)</u> |
| <u>[4.](https://www.sec.gov/Archives/edgar/data/1434868/000104746913006083/a2214660zex-4_5.htm)[10](https://www.sec.gov/Archives/edgar/data/1434868/000104746913006083/a2214660zex-4_5.htm)</u> | <u>[Amendment No. 1 to Investor Rights Agreement by and between the Registrant and certain of its stockholders dated April 11, 2013 (incorporated by reference to Exhibit 4.5 to the Registrant's Registration Statement on Form S-1, as amended (File No. 333-188595) filed on May 14, 2013).](https://www.sec.gov/Archives/edgar/data/1434868/000104746913006083/a2214660zex-4_5.htm)</u> |
| <u>[5.1\*](exhibit5182025.htm)</u> | <u>[Opinion of Goodwin Procter LLP](exhibit5182025.htm)</u>. |
| <u>[23.1\*](exhibit23182025.htm)</u> | <u>[Consent of Ernst & Young LLP, Independent Registered Public Accounting Firm](exhibit23182025.htm)</u>. |
| <u>[23.2\*](exhibit5182025.htm)</u> | <u>[Consent of Goodwin Procter LLP (included in Exhibit 5.1)](exhibit5182025.htm)</u>. |
| <u>[24.1\*](#if3a688797a2e414084ebdc55f7ec3cd7_13)</u> | <u>[Power of Attorney (included on signature page)](#if3a688797a2e414084ebdc55f7ec3cd7_13)</u>. |
| <u>[99.1](https://www.sec.gov/Archives/edgar/data/1434868/000162828022015495/exhibit99152022.htm)</u> | <u>[2022 Stock Option and Incentive Plan and forms of agreements thereunder (incorporated by reference to Exhibit 99.1 to the Registrant's Registration Statement on Form S-8 (File No. 333-265247) filed on May 26, 2022)](https://www.sec.gov/Archives/edgar/data/1434868/000162828022015495/exhibit99152022.htm)</u>. |
| <u>[99.2](https://www.sec.gov/Archives/edgar/data/1434868/000162828023022276/exhibit10162023.htm)</u> | <u>[First Amendment to 2022 Stock Option and Incentive Plan (incorporated by reference to Exhibit 10.1 to the Registrant's Current Report on Form 8-K filed on June 15, 2023)](https://www.sec.gov/Archives/edgar/data/1434868/000162828023022276/exhibit10162023.htm)</u>.  |
| <u>[99.3](https://www.sec.gov/Archives/edgar/data/0001434868/000162828024025418/exhibit101.htm)</u> | <u>[Second Amendment to 2022 Stock Option and Incentive Plan (incorporated by reference to Exhibit 10.1 to the Registrant's Current Report on Form 8-K filed on May 28, 2024).](https://www.sec.gov/Archives/edgar/data/0001434868/000162828024025418/exhibit101.htm)</u> |
| <u>[99.4](https://www.sec.gov/Archives/edgar/data/1434868/000162828025028820/exhibit1011.htm)</u> | <u>[Th](https://www.sec.gov/Archives/edgar/data/1434868/000162828025028820/exhibit1011.htm)[ird](https://www.sec.gov/Archives/edgar/data/1434868/000162828025028820/exhibit1011.htm)[Amendment to 2022 Stock Option and Incentive Plan (incorporated by reference to Exhibit 10.1 to the Registrant's Current Report on Form 8-K filed on](https://www.sec.gov/Archives/edgar/data/1434868/000162828025028820/exhibit1011.htm)[June 2](https://www.sec.gov/Archives/edgar/data/1434868/000162828025028820/exhibit1011.htm)[, 202](https://www.sec.gov/Archives/edgar/data/1434868/000162828025028820/exhibit1011.htm)[5](https://www.sec.gov/Archives/edgar/data/1434868/000162828025028820/exhibit1011.htm)[).](https://www.sec.gov/Archives/edgar/data/1434868/000162828025028820/exhibit1011.htm)</u> |
| <u>[107\*](exfilingfees.htm)</u> | <u>[Filing Fee Table](exfilingfees.htm)</u>. |

---

\* Filed herewith.

------

**SIGNATURES**

Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Ann Arbor, State of Michigan, on the 13th day of August, 2025.

---

| | |
|:---|:---|
| **ESPERION THERAPEUTICS, INC.** | **ESPERION THERAPEUTICS, INC.** |
| By: | /s/ Sheldon L. Koenig |
|  | Sheldon L. Koenig |
|  | President, Chief Executive Officer and Director |

---

**POWER OF ATTORNEY AND SIGNATURES**

We, the undersigned officers and directors of Esperion Therapeutics, Inc., hereby severally constitute and appoint Sheldon L. Koenig, and each of them singly (with full power to each of them to act alone), our true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution in each of them for him or her and in his or her name, place and stead, and in any and all capacities, to sign for us and in our names in the capacities indicated below any and all amendments (including post-effective amendments) to this Registration Statement on Form S-8, and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite or necessary to be done in and about the premises, as full to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents or any of them, or their or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the date indicated below.

---

| | | |
|:---|:---|:---|
| **Signature** | **Title** | **Date** |
| /s/ Sheldon L. Koenig | President, Chief Executive Officer and Director (Principal Executive Officer) |  |
| Sheldon L. Koenig | President, Chief Executive Officer and Director (Principal Executive Officer) | August 13, 2025 |
| /s/ Benjamin Halladay | Chief Financial Officer (Principal Financial Officer, and Principal Accounting Officer) |  |
| Benjamin Halladay | Chief Financial Officer (Principal Financial Officer, and Principal Accounting Officer) | August 13, 2025 |
| /s/ J. Martin Carroll | Director | August 13, 2025 |
| J. Martin Carroll |  |  |
| /s/ Seth H.Z. Fischer | Director | August 13, 2025 |
| Seth H.Z. Fischer |  |  |
| /s/ Robert E. Hoffman | Director | August 13, 2025 |
| Robert E. Hoffman |  |  |
| /s/ Stephen Rocamboli | Director | August 13, 2025 |
| Stephen Rocamboli |  |  |
| /s/ Jay Shepard | Director | August 13, 2025 |
| Jay Shepard |  |  |
| /s/ Craig Thompson | Director | August 13, 2025 |
| Craig Thompson |  |  |
| /s/ Tracy M. Woody | Director | August 13, 2025 |
| Tracy M. Woody |  |  |

---

## Ex-Filing

?xml version='1.0' encoding='ASCII'? exfilingfees

**Exhibit 107**

**Calculation of Filing Fee Tables**

**Form S-8**

(Form Type)

**Esperion Therapeutics, Inc.** 

(Exact Name of Registrant as Specified in its Charter)

<u>Table 1: Newly Registered Securities</u>

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| **Security Type** | **Security Class Title** | **Fee Calculation Rule** | **Amount Registered (1) (2)** | **Proposed Maximum Offering Price Per Share (3)** | **Maximum Aggregate Offering Price** | **Fee Rate** | **Amount of Registration Fee** |
| Equity | Common stock, par value $0.001 per share | Rule 457 (c) and Rule 457(h) | &nbsp;&nbsp;6250000 | $1.79 | $11187500 | $0.0001531 | $1712.81 |
| **Total Offering Amounts** | **Total Offering Amounts** | **Total Offering Amounts** | **Total Offering Amounts** |  | $11187500 |  | $1712.81 |
| **Total Fee Offsets** | **Total Fee Offsets** | **Total Fee Offsets** | **Total Fee Offsets** |  |  |  | $— |
| **Net Fee Due** | **Net Fee Due** | **Net Fee Due** | **Net Fee Due** |  |  |  | $1712.81 |
| (1) Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement on Form S-8 (this "Registration Statement") shall also cover any additional shares of common stock, par value $0.001 per share ("Common Stock"), of Esperion Therapeutics, Inc. (the "Registrant"), which become issuable under the Registrant's 2022 Stock Option and Incentive Plan, as amended (the "Option Plan") by reason of any stock dividend, stock split, recapitalization or any other similar transaction effected without the receipt of consideration which results in an increase in the number of the Registrant's outstanding shares of Common Stock. Pursuant to Rule 416(c) under the Securities Act, this Registration Statement shall also cover an indeterminate amount of interests to be offered or sold pursuant to the employee benefit plans described herein.<br>(2) Represents an increase of 6,250,000 shares of Common Stock to the number of shares available for issuance under the Option Plan. Shares available for issuance under the Option Plan were previously registered on the Registrant's registration statements on Form S-8 (Registration No. 333-265247, Registration No. 333-273555, and Registration No. 333-281486) filed with the Securities and Exchange Commission (the "Commission") on May 26, 2022, August 1, 2023, and August 12, 2024, respectively. <br>(3) The price of $1.79 per share, which is the average of the high and low sale prices of Common Stock as quoted on the Nasdaq Global Market on August 8, 2025, is set forth solely for purposes of calculating the registration fee pursuant to Rules 457(c) and (h) of the Securities Act, and has been used as these shares are without a fixed price. | (1) Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement on Form S-8 (this "Registration Statement") shall also cover any additional shares of common stock, par value $0.001 per share ("Common Stock"), of Esperion Therapeutics, Inc. (the "Registrant"), which become issuable under the Registrant's 2022 Stock Option and Incentive Plan, as amended (the "Option Plan") by reason of any stock dividend, stock split, recapitalization or any other similar transaction effected without the receipt of consideration which results in an increase in the number of the Registrant's outstanding shares of Common Stock. Pursuant to Rule 416(c) under the Securities Act, this Registration Statement shall also cover an indeterminate amount of interests to be offered or sold pursuant to the employee benefit plans described herein.<br>(2) Represents an increase of 6,250,000 shares of Common Stock to the number of shares available for issuance under the Option Plan. Shares available for issuance under the Option Plan were previously registered on the Registrant's registration statements on Form S-8 (Registration No. 333-265247, Registration No. 333-273555, and Registration No. 333-281486) filed with the Securities and Exchange Commission (the "Commission") on May 26, 2022, August 1, 2023, and August 12, 2024, respectively. <br>(3) The price of $1.79 per share, which is the average of the high and low sale prices of Common Stock as quoted on the Nasdaq Global Market on August 8, 2025, is set forth solely for purposes of calculating the registration fee pursuant to Rules 457(c) and (h) of the Securities Act, and has been used as these shares are without a fixed price. | (1) Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement on Form S-8 (this "Registration Statement") shall also cover any additional shares of common stock, par value $0.001 per share ("Common Stock"), of Esperion Therapeutics, Inc. (the "Registrant"), which become issuable under the Registrant's 2022 Stock Option and Incentive Plan, as amended (the "Option Plan") by reason of any stock dividend, stock split, recapitalization or any other similar transaction effected without the receipt of consideration which results in an increase in the number of the Registrant's outstanding shares of Common Stock. Pursuant to Rule 416(c) under the Securities Act, this Registration Statement shall also cover an indeterminate amount of interests to be offered or sold pursuant to the employee benefit plans described herein.<br>(2) Represents an increase of 6,250,000 shares of Common Stock to the number of shares available for issuance under the Option Plan. Shares available for issuance under the Option Plan were previously registered on the Registrant's registration statements on Form S-8 (Registration No. 333-265247, Registration No. 333-273555, and Registration No. 333-281486) filed with the Securities and Exchange Commission (the "Commission") on May 26, 2022, August 1, 2023, and August 12, 2024, respectively. <br>(3) The price of $1.79 per share, which is the average of the high and low sale prices of Common Stock as quoted on the Nasdaq Global Market on August 8, 2025, is set forth solely for purposes of calculating the registration fee pursuant to Rules 457(c) and (h) of the Securities Act, and has been used as these shares are without a fixed price. | (1) Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement on Form S-8 (this "Registration Statement") shall also cover any additional shares of common stock, par value $0.001 per share ("Common Stock"), of Esperion Therapeutics, Inc. (the "Registrant"), which become issuable under the Registrant's 2022 Stock Option and Incentive Plan, as amended (the "Option Plan") by reason of any stock dividend, stock split, recapitalization or any other similar transaction effected without the receipt of consideration which results in an increase in the number of the Registrant's outstanding shares of Common Stock. Pursuant to Rule 416(c) under the Securities Act, this Registration Statement shall also cover an indeterminate amount of interests to be offered or sold pursuant to the employee benefit plans described herein.<br>(2) Represents an increase of 6,250,000 shares of Common Stock to the number of shares available for issuance under the Option Plan. Shares available for issuance under the Option Plan were previously registered on the Registrant's registration statements on Form S-8 (Registration No. 333-265247, Registration No. 333-273555, and Registration No. 333-281486) filed with the Securities and Exchange Commission (the "Commission") on May 26, 2022, August 1, 2023, and August 12, 2024, respectively. <br>(3) The price of $1.79 per share, which is the average of the high and low sale prices of Common Stock as quoted on the Nasdaq Global Market on August 8, 2025, is set forth solely for purposes of calculating the registration fee pursuant to Rules 457(c) and (h) of the Securities Act, and has been used as these shares are without a fixed price. | (1) Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement on Form S-8 (this "Registration Statement") shall also cover any additional shares of common stock, par value $0.001 per share ("Common Stock"), of Esperion Therapeutics, Inc. (the "Registrant"), which become issuable under the Registrant's 2022 Stock Option and Incentive Plan, as amended (the "Option Plan") by reason of any stock dividend, stock split, recapitalization or any other similar transaction effected without the receipt of consideration which results in an increase in the number of the Registrant's outstanding shares of Common Stock. Pursuant to Rule 416(c) under the Securities Act, this Registration Statement shall also cover an indeterminate amount of interests to be offered or sold pursuant to the employee benefit plans described herein.<br>(2) Represents an increase of 6,250,000 shares of Common Stock to the number of shares available for issuance under the Option Plan. Shares available for issuance under the Option Plan were previously registered on the Registrant's registration statements on Form S-8 (Registration No. 333-265247, Registration No. 333-273555, and Registration No. 333-281486) filed with the Securities and Exchange Commission (the "Commission") on May 26, 2022, August 1, 2023, and August 12, 2024, respectively. <br>(3) The price of $1.79 per share, which is the average of the high and low sale prices of Common Stock as quoted on the Nasdaq Global Market on August 8, 2025, is set forth solely for purposes of calculating the registration fee pursuant to Rules 457(c) and (h) of the Securities Act, and has been used as these shares are without a fixed price. | (1) Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement on Form S-8 (this "Registration Statement") shall also cover any additional shares of common stock, par value $0.001 per share ("Common Stock"), of Esperion Therapeutics, Inc. (the "Registrant"), which become issuable under the Registrant's 2022 Stock Option and Incentive Plan, as amended (the "Option Plan") by reason of any stock dividend, stock split, recapitalization or any other similar transaction effected without the receipt of consideration which results in an increase in the number of the Registrant's outstanding shares of Common Stock. Pursuant to Rule 416(c) under the Securities Act, this Registration Statement shall also cover an indeterminate amount of interests to be offered or sold pursuant to the employee benefit plans described herein.<br>(2) Represents an increase of 6,250,000 shares of Common Stock to the number of shares available for issuance under the Option Plan. Shares available for issuance under the Option Plan were previously registered on the Registrant's registration statements on Form S-8 (Registration No. 333-265247, Registration No. 333-273555, and Registration No. 333-281486) filed with the Securities and Exchange Commission (the "Commission") on May 26, 2022, August 1, 2023, and August 12, 2024, respectively. <br>(3) The price of $1.79 per share, which is the average of the high and low sale prices of Common Stock as quoted on the Nasdaq Global Market on August 8, 2025, is set forth solely for purposes of calculating the registration fee pursuant to Rules 457(c) and (h) of the Securities Act, and has been used as these shares are without a fixed price. | (1) Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement on Form S-8 (this "Registration Statement") shall also cover any additional shares of common stock, par value $0.001 per share ("Common Stock"), of Esperion Therapeutics, Inc. (the "Registrant"), which become issuable under the Registrant's 2022 Stock Option and Incentive Plan, as amended (the "Option Plan") by reason of any stock dividend, stock split, recapitalization or any other similar transaction effected without the receipt of consideration which results in an increase in the number of the Registrant's outstanding shares of Common Stock. Pursuant to Rule 416(c) under the Securities Act, this Registration Statement shall also cover an indeterminate amount of interests to be offered or sold pursuant to the employee benefit plans described herein.<br>(2) Represents an increase of 6,250,000 shares of Common Stock to the number of shares available for issuance under the Option Plan. Shares available for issuance under the Option Plan were previously registered on the Registrant's registration statements on Form S-8 (Registration No. 333-265247, Registration No. 333-273555, and Registration No. 333-281486) filed with the Securities and Exchange Commission (the "Commission") on May 26, 2022, August 1, 2023, and August 12, 2024, respectively. <br>(3) The price of $1.79 per share, which is the average of the high and low sale prices of Common Stock as quoted on the Nasdaq Global Market on August 8, 2025, is set forth solely for purposes of calculating the registration fee pursuant to Rules 457(c) and (h) of the Securities Act, and has been used as these shares are without a fixed price. | (1) Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement on Form S-8 (this "Registration Statement") shall also cover any additional shares of common stock, par value $0.001 per share ("Common Stock"), of Esperion Therapeutics, Inc. (the "Registrant"), which become issuable under the Registrant's 2022 Stock Option and Incentive Plan, as amended (the "Option Plan") by reason of any stock dividend, stock split, recapitalization or any other similar transaction effected without the receipt of consideration which results in an increase in the number of the Registrant's outstanding shares of Common Stock. Pursuant to Rule 416(c) under the Securities Act, this Registration Statement shall also cover an indeterminate amount of interests to be offered or sold pursuant to the employee benefit plans described herein.<br>(2) Represents an increase of 6,250,000 shares of Common Stock to the number of shares available for issuance under the Option Plan. Shares available for issuance under the Option Plan were previously registered on the Registrant's registration statements on Form S-8 (Registration No. 333-265247, Registration No. 333-273555, and Registration No. 333-281486) filed with the Securities and Exchange Commission (the "Commission") on May 26, 2022, August 1, 2023, and August 12, 2024, respectively. <br>(3) The price of $1.79 per share, which is the average of the high and low sale prices of Common Stock as quoted on the Nasdaq Global Market on August 8, 2025, is set forth solely for purposes of calculating the registration fee pursuant to Rules 457(c) and (h) of the Securities Act, and has been used as these shares are without a fixed price. |

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## Exhibit 5.1

**Exhibit 5.1**

August 13, 2025

Esperion Therapeutics, Inc.

3891 Ranchero Drive, Suite 150

Ann Arbor, MI 48108

Re: <u>Securities Being Registered under Registration Statement on Form S-8</u>

We have acted as your counsel in connection with your filing of a Registration Statement on Form S-8 (the "Registration Statement") pursuant to the Securities Act of 1933, as amended (the "Securities Act"), on or about the date hereof relating to an aggregate of 6,250,000 shares (the "Shares") of Common Stock, $0.001 par value per share (the "Common Stock"), of Esperion Therapeutics, Inc., a Delaware corporation (the "Company"), that may be issued pursuant to the Company's 2022 Stock Option and Incentive Plan, as amended (the "Plan").

We have reviewed such documents and made such examination of law as we have deemed appropriate to give the opinion set forth below. We have relied, without independent verification, on certificates of public officials and, as to matters of fact material to the opinion set forth below, on certificates of officers of the Company.

For purposes of the opinion set forth below, we have assumed that, at the time the Shares are issued, the total number of then unissued Shares, when added to the number of shares of Common Stock issued, subscribed for, or otherwise committed to be issued, does not exceed the number of shares of Common Stock authorized by the Company's certificate of incorporation.

The opinion set forth below is limited to the Delaware General Corporation Law.

Based on the foregoing, we are of the opinion that the Shares have been duly authorized and, when delivered against payment therefor in accordance with the terms of the Plan, will be validly issued, fully paid and nonassessable.

This opinion letter and the opinion it contains shall be interpreted in accordance with the Core Opinion Principles as published in 74 Business Lawyer 815 (Summer 2019).

We hereby consent to the inclusion of this opinion as Exhibit 5.1 to the Registration Statement. In giving our consent, we do not admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations thereunder.

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| |
|:---|
| Very truly yours, |
| /s/ GOODWIN PROCTER LLP |
| GOODWIN PROCTER LLP |

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## Exhibit 23.1

**Exhibit 23.1**

**Consent of Independent Registered Public Accounting Firm**

We consent to the incorporation by reference in the Registration Statement (Form S-8) pertaining to the Esperion Therapeutics, Inc. 2022 Stock Option and Incentive Plan, as amended, of our report dated March 7, 2025, with respect to the financial statements of Esperion Therapeutics, Inc. included in its Annual Report (Form 10-K) for the year ended December 31, 2024, filed with the Securities and Exchange Commission.

/s/ Ernst & Young LLP

Detroit, Michigan

August 13, 2025

<br>