# EDGAR Filing Document

**Accession Number:** 0000836487
**File Stem:** 0001410368-26-018428
**Filing Date:** 2026-2
**Character Count:** 17130
**Document Hash:** a04e0c31438a56e086ae228862bc300f
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001410368-26-018428.hdr.sgml**: 20260226

**ACCESSION NUMBER**: 0001410368-26-018428

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20251231

**FILED AS OF DATE**: 20260226

**DATE AS OF CHANGE**: 20260226

**PERIOD START**: 20251231

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** MORGAN STANLEY INSTITUTIONAL FUND INC
- **CENTRAL INDEX KEY:** 0000836487

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** MD
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-05624
- **FILM NUMBER:** 26683252

**BUSINESS ADDRESS:**
- **STREET 1:** 1585 BROADWAY
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10036
- **BUSINESS PHONE:** 800-548-7786

**MAIL ADDRESS:**
- **STREET 1:** 1585 BROADWAY
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10036

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** MORGAN STANLEY DEAN WITTER INSTITUTIONAL FUND INC
- **DATE OF NAME CHANGE:** 19990329

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** MORGAN STANLEY INSTITUTIONAL FUND INC
- **DATE OF NAME CHANGE:** 19920703

## Series and Classes Contracts Data

### Vitality Portfolio (Series ID: S000074797)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000233002 | Class I      | MSVDX           |
| C000233003 | Class A      | MSVEX           |
| C000233004 | Class C      | MSVMX           |
| C000233005 | Class R6     | MSVOX           |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** MORGAN STANLEY INSTITUTIONAL FUND INC

- **b. Investment Company Act file number:** 811-05624

- **c. CIK number of Registrant:** 0000836487

- **d. LEI of Registrant:** 54930067DYRSUSGS4E97

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 1585 Broadway

  - **City:** NEW YORK

  - **State:** NY

  - **Foreign country:** US

  - **Zip / Postal Code:** 10036

  - **Telephone number:** 800-869-6397

**Item A.2. Information about the Series.**

- **a. Name of Series:** Vitality Portfolio

- **b. EDGAR series identifier (if any):** S000074797

- **c. LEI of Series:** 549300V9WWJX6LPH4Y61

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2025-12-31

- **b. Date as of which information is reported:** 2025-12-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $2404871.59

**Total Liabilities:** $60989.96

**Net Assets:** $2343881.63

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000233002 | 8.43%                | 8.10%                | -1.80%               |
| Class ID C000233003 | 8.51%                | 8.00%                | -1.81%               |
| Class ID C000233004 | 8.51%                | 8.01%                | -2.01%               |
| Class ID C000233005 | 8.61%                | 8.08%                | -1.90%               |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $-160021.81              | $334008.09                                 |
| Month 2  | $-34618.44               | $210560.57                                 |
| Month 3  | $0.00                    | $-42271.30                                 |

### Schedule of Portfolio Investments

| Name                                               | Title                                                                        | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Align Technology Inc                               | Align Technology Inc                                                         | CUSIP: 016255101<br>LEI: 549300N5YSE0U3LCP840 | Long             | EC               | CORP              | US        |       521 | NS      | $81354.15     | 3.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals Inc                        | Alnylam Pharmaceuticals Inc                                                  | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |       271 | NS      | $107763.15    | 4.60%             |  |  |  | No            |                  1 | On Loan: No      |
| Argenx SE                                          | Argenx SE                                                                    | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |       235 | NS      | $197623.25    | 8.43%             |  |  |  | No            |                  1 | On Loan: No      |
| Ascendis Pharma A/S                                | Ascendis Pharma A/S                                                          | CUSIP: 04351P101<br>LEI: 549300B66JN3W3J8GH73 | Long             | EC               | CORP              | DK        |       512 | NS      | $109178.88    | 4.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Beam Therapeutics Inc                              | Beam Therapeutics Inc                                                        | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1602 | NS      | $44407.44     | 1.89%             |  |  |  | No            |                  1 | On Loan: No      |
| Ceribell Inc                                       | Ceribell Inc                                                                 | CUSIP: 15678C102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3915 | NS      | $85855.95     | 3.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Enliven Therapeutics Inc                           | Enliven Therapeutics Inc                                                     | CUSIP: 29337E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2126 | NS      | $32740.40     | 1.40%             |  |  |  | No            |                  1 | On Loan: No      |
| Exact Sciences Corp                                | Exact Sciences Corp                                                          | CUSIP: 30063P105<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |      2200 | NS      | $223432.00    | 9.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Illumina Inc                                       | Illumina Inc                                                                 | CUSIP: 452327109<br>LEI: SQ95QG8SR5Q56LSNF682 | Long             | EC               | CORP              | US        |       437 | NS      | $57316.92     | 2.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Inspire Medical Systems Inc                        | Inspire Medical Systems Inc                                                  | CUSIP: 457730109<br>LEI: 549300XQQCQ7HCJKTW25 | Long             | EC               | CORP              | US        |       689 | NS      | $63546.47     | 2.71%             |  |  |  | No            |                  1 | On Loan: No      |
| Intuitive Surgical Inc                             | Intuitive Surgical Inc                                                       | CUSIP: 46120E602<br>LEI: 54930052SRG011710797 | Long             | EC               | CORP              | US        |       132 | NS      | $74759.52     | 3.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Kymera Therapeutics Inc                            | Kymera Therapeutics Inc                                                      | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       534 | NS      | $41550.54     | 1.77%             |  |  |  | No            |                  1 | On Loan: No      |
| Eli Lilly & Co                                     | Eli Lilly & Co                                                               | CUSIP: 532457108<br>LEI: FRDRIPF3EKNDJ2CQJL29 | Long             | EC               | CORP              | US        |       181 | NS      | $194517.08    | 8.30%             |  |  |  | No            |                  1 | On Loan: No      |
| MaxCyte Inc                                        | MaxCyte Inc                                                                  | CUSIP: 57777K106<br>LEI: 54930053YHXULRFCU991 | Long             | EC               | CORP              | US        |     31208 | NS      | $48372.40     | 2.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Nektar Therapeutics                                | Nektar Therapeutics                                                          | CUSIP: 640268306<br>LEI: 5299005I24806IOIYE03 | Long             | EC               | CORP              | US        |       523 | NS      | $22112.44     | 0.94%             |  |  |  | No            |                  1 | On Loan: No      |
| Schrodinger Inc/United States                      | Schrodinger Inc/United States                                                | CUSIP: 80810D103<br>LEI: 984500044BAE4791E559 | Long             | EC               | CORP              | US        |      2552 | NS      | $45629.76     | 1.95%             |  |  |  | No            |                  1 | On Loan: No      |
| Structure Therapeutics Inc                         | Structure Therapeutics Inc                                                   | CUSIP: 86366E106<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |      1489 | NS      | $103559.95    | 4.42%             |  |  |  | No            |                  1 | On Loan: No      |
| 10X Genomics Inc                                   | 10X Genomics Inc                                                             | CUSIP: 88025U109<br>LEI: 5493003Z6741WNLG7H43 | Long             | EC               | CORP              | US        |      3801 | NS      | $61994.31     | 2.64%             |  |  |  | No            |                  1 | On Loan: No      |
| Thermo Fisher Scientific Inc                       | Thermo Fisher Scientific Inc                                                 | CUSIP: 883556102<br>LEI: HCHV7422L5HDJZCRFL38 | Long             | EC               | CORP              | US        |       186 | NS      | $107777.70    | 4.60%             |  |  |  | No            |                  1 | On Loan: No      |
| Ultragenyx Pharmaceutical Inc                      | Ultragenyx Pharmaceutical Inc                                                | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |       758 | NS      | $17434.00     | 0.74%             |  |  |  | No            |                  1 | On Loan: No      |
| UnitedHealth Group Inc                             | UnitedHealth Group Inc                                                       | CUSIP: 91324P102<br>LEI: 549300GHBMY8T5GXDE41 | Long             | EC               | CORP              | US        |       172 | NS      | $56778.92     | 2.42%             |  |  |  | No            |                  1 | On Loan: No      |
| Vaxcyte Inc                                        | Vaxcyte Inc                                                                  | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |       952 | NS      | $43925.28     | 1.87%             |  |  |  | No            |                  1 | On Loan: No      |
| Veeva Systems Inc                                  | Veeva Systems Inc                                                            | CUSIP: 922475108<br>LEI: 549300YZEXPDB92M2F02 | Long             | EC               | CORP              | US        |       190 | NS      | $42413.70     | 1.81%             |  |  |  | No            |                  1 | On Loan: No      |
| Morgan Stanley & Co. LLC                           | Morgan Stanley Institutional Liquidity Funds - Treasury Securities Portfolio | CUSIP: 61747C525<br>LEI: 549300OJY9IZ31SGS926 | Long             | STIV             | RF                | US        |     30388 | NS      | $30388.16     | 1.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals Inc                         | Vertex Pharmaceuticals Inc                                                   | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |       128 | NS      | $58030.08     | 2.48%             |  |  |  | No            |                  1 | On Loan: No      |
| West Pharmaceutical Services Inc                   | West Pharmaceutical Services Inc                                             | CUSIP: 955306105<br>LEI: 5493007NKRGM1RJQ1P16 | Long             | EC               | CORP              | US        |       146 | NS      | $40170.44     | 1.71%             |  |  |  | No            |                  1 | On Loan: No      |
| Morgan Stanley & Co. LLC                           | Morgan Stanley Institutional Liquidity Funds - Treasury Securities Portfolio | CUSIP: 61747C525<br>LEI: 549300OJY9IZ31SGS926 | Long             | STIV             | RF                | US        |     91461 | NS      | $91460.56     | 3.90%             |  |  |  | No            |                  1 | On Loan: No      |
| Zoetis Inc                                         | Zoetis Inc                                                                   | CUSIP: 98978V103<br>LEI: 549300HD9Q1LOC9KLJ48 | Long             | EC               | CORP              | US        |       411 | NS      | $51712.02     | 2.21%             |  |  |  | No            |                  1 | On Loan: No      |
| HSBC Securities (USA) Inc.                         | HSBC TRI PARTY   A REPO                                                      | CUSIP: 000000000<br>LEI: CYYGQCGNHMHPSMRL3R97 | Long             | RA               | CORP              | US        |      3101 | PA      | $3100.83      | 0.13%             |  |  |  | No            |                  2 | On Loan: No      |
| Merrill Lynch, Pierce, Fenner & Smith Incorporated | MERRILL LYNCH TRI PARTY A REPO                                               | CUSIP: 000000000<br>LEI: 8NAV47T0Y26Q87Y0QP81 | Long             | RA               | CORP              | US        |      7442 | PA      | $7442.00      | 0.32%             |  |  |  | No            |                  2 | On Loan: No      |
| Merrill Lynch, Pierce, Fenner & Smith Incorporated | MERRILL LYNCH TRI PARTY A REPO                                               | CUSIP: 000000000<br>LEI: 8NAV47T0Y26Q87Y0QP81 | Long             | RA               | CORP              | US        |       961 | PA      | $961.26       | 0.04%             |  |  |  | No            |                  2 | On Loan: No      |
| Atai Beckley NV                                    | Atai Beckley NV                                                              | CUSIP: 000000000<br>LEI: 391200Z8UWPJSNBNCA11 | Long             | EC               | CORP              | NL        |      9857 | NS      | $40315.13     | 1.72%             |  |  |  | No            |                  1 | On Loan: —       |
| Newamsterdam Pharma Co NV                          | Newamsterdam Pharma Co NV                                                    | CUSIP: 000000000<br>LEI: 984500B6549TF6E14D36 | Long             | EC               | CORP              | NL        |      2383 | NS      | $83595.64     | 3.57%             |  |  |  | No            |                  1 | On Loan: No      |
| uniQure NV                                         | uniQure NV                                                                   | CUSIP: 000000000<br>LEI: 724500RPCTZLFYJZ3S98 | Long             | EC               | CORP              | NL        |       746 | NS      | $17851.78     | 0.76%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2026-01-16

**Name of Applicant:** MORGAN STANLEY INSTITUTIONAL FUND INC

**Signature:** Francis Smith

**Name of Signer:** Francis Smith

**Title:** Principal Financial Officer