# EDGAR Filing Document

**Accession Number:** 0001404644
**File Stem:** 0001628280-23-008655
**Filing Date:** 2023-3
**Character Count:** 25551
**Document Hash:** c5916ecf203657ab08345674214292ab
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001628280-23-008655.hdr.sgml**: 20230321

**ACCESSION NUMBER**: 0001628280-23-008655

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 4

**FILED AS OF DATE**: 20230321

**DATE AS OF CHANGE**: 20230320

**EFFECTIVENESS DATE**: 20230321

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Neoleukin Therapeutics, Inc.
- **CENTRAL INDEX KEY:** 0001404644
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-270704
- **FILM NUMBER:** 23747485

**BUSINESS ADDRESS:**
- **STREET 1:** SUITE 360 - 1616 EASTLAKE AVE EAST
- **CITY:** SEATTLE
- **STATE:** WA
- **ZIP:** 98102
- **BUSINESS PHONE:** 206-732-2133

**MAIL ADDRESS:**
- **STREET 1:** SUITE 360 - 1616 EASTLAKE AVE EAST
- **CITY:** SEATTLE
- **STATE:** WA
- **ZIP:** 98102

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** AQUINOX PHARMACEUTICALS, INC
- **DATE OF NAME CHANGE:** 20140128

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** AQUINOX PHARMACEUTICALS (USA) INC
- **DATE OF NAME CHANGE:** 20070626

**As filed with the U.S. Securities and Exchange Commission on March 20, 2023**

**Registration No. 333-**

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**Washington, D.C. 20549** 

**_________________________**

**FORM S-8** 

**REGISTRATION STATEMENT** 

***UNDER***

***THE SECURITIES ACT OF 1933***

**_________________________**

**NEOLEUKIN THERAPEUTICS, INC.** 

**(Exact name of registrant as specified in its charter)** 

**_________________________**

---

| | |
|:---|:---|
| **Delaware** | **98-0542593** |
| **(State or other jurisdiction of incorporation or organization)** | **(I.R.S. Employer Identification No.)** |

---

**188 East Blaine Street, Suite 450**

**Seattle, Washington 98102**

**(866) 245-0312** 

**(Address of principal executive offices) (Zip code)** 

**Amended and Restated Neoleukin Therapeutics, Inc.** 

**2014 Equity Incentive Plan** 

**(Full title of the plan)** 

**Jonathan G. Drachman**

**Chief Executive Officer**

**Neoleukin Therapeutics, Inc.**

**188 East Blaine Street, Suite 450<br>Seattle, Washington 98102**

**(866) 245-0312**

 **(Name and address of agent for service) (Telephone number, including area code, of agent for service)** 

**________________________**

***Please send copies of all communications to:***

**Effie Toshav, Esq.**

**Robert Freedman, Esq.**

**Julia Forbess, Esq.**

**Fenwick & West LLP<br>555 California Street, 12th Floor**

**San Francisco, California 94104<br>(415) 875-2300**

**_________________________**

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☐ | Accelerated filer | ☐ |
| Non-accelerated filer | ☒  | Smaller reporting company | ☒ |
| | | Emerging growth company | ☐ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

    

------

**EXPLANATORY NOTE** 

**REGISTRATION OF ADDITIONAL SHARES PURSUANT TO GENERAL INSTRUCTION**

This Registration Statement on Form S-8 is being filed by Neoleukin Therapeutics, Inc. (the "Registrant") for the purpose of registering an additional 2,212,454 shares of the Registrant's common stock to be issued pursuant to the Registrant's Amended and Restated 2014 Equity Incentive Plan (the "2014 EIP"). These additional shares of common stock are securities of the same class as other securities for which registration statements on Form S-8 (File Nos. 333-194490, 333-203179, 333-210172, 333-216572, 333-223589, 333-234734, 333-237124, 333-254725, and 333-263190) were filed with the Securities and Exchange Commission (the "Commission") on March 11, 2014, April 1, 2015, March 14, 2016, March 9, 2017, March 12, 2018, November 15, 2019, March 12, 2020, March 25, 2021, and March 1, 2022, respectively. These additional shares of common stock have become reserved for issuance as a result of the operation of the "evergreen" provision in the 2014 EIP, which provides that the total number of shares subject to such plan will be increased on January 1 of each year pursuant to a specified formula through January 1, 2030.

**PART II** 

**ITEM 3.&nbsp;&nbsp;&nbsp;&nbsp;INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE**

The following documents filed by the Registrant with the Commission are incorporated by reference into this Registration Statement:

**(a)** the description of the Registrant's common stock which is contained in the Registrant's registration statement on Form 8-A filed on March 3, 2014 (File No. 001-36327) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), including any amendment or report filed for the purpose of updating such description;

**(b)** the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2022, which includes audited financial statements for the Registrant's latest fiscal year, filed with the Commission on March 20, 2023;

**(c)** the Registrant's Current Reports on Form 8-K filed with the Commission on January 23, 2023 and March 10, 2023; and

**(d)** all other reports and documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act (other than Current Reports furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits furnished on such form that relate to such items) on or after the date of this Registration Statement and prior to the filing of a post-effective amendment to this Registration Statement which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part of this Registration Statement from the date of the filing of such reports and documents. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently filed document that also is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.

------

**ITEM 8.&nbsp;&nbsp;&nbsp;&nbsp;EXHIBITS**

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| | | **Incorporated by Reference** | **Incorporated by Reference** | **Incorporated by Reference** | **Incorporated by Reference** | |
| <br>**Exhibit**<br>**Number** |<br>**Exhibit Description** | **Form** | **File No.** | **Exhibit** | **Filing Date** | **Filed**<br>**Herewith** |
| 4.1 | <u>[Amended and Restated Certificate of Incorporation of the Registrant](https://www.sec.gov/Archives/edgar/data/1404644/000119312514095845/d688616dex31.htm)</u> | 8-K | 001-36327 | 3.1 | March 12, 2014 |  |
| 4.2 | <u>[Certificate of Amendment to Amended and Restated Certificate of Incorporation of the Registrant](https://www.sec.gov/Archives/edgar/data/0001404644/000119312519290610/d821827dex34.htm)</u> | 10-Q | 001-36327 | 3.4 | November 13, 2019 |  |
| 4.3 | <u>[Certificate of Amendment to Amended and Restated Certificate of Incorporation of the Registrant](https://www.sec.gov/Archives/edgar/data/0001404644/000119312519290610/d821827dex35.htm)</u> | 10-Q | 001-36327 | 3.5 | November 13, 2019 |  |
| 4.4 | <u>[Amended and Restated Bylaws of the Registrant](https://www.sec.gov/Archives/edgar/data/0001404644/000119312520104856/d906686dex31.htm)</u> | 8-K/A | 001-36327 | 3.1 | January 23, 2023 |  |
| 4.5 | <u>[Specimen Common Stock Certificate of the Registrant](https://www.sec.gov/Archives/edgar/data/1404644/000119312514195836/d704250dex41.htm)</u> | 10-Q | 001-36327 | 4.1 | May 13, 2014 |  |
| 5.1 | <u>[Opinion of Fenwick & West LLP](exhibit51-opinionoffenwick.htm)</u> |  |  |  |  | X |
| 23.1 | <u>[Consent of Deloitte & Touche LLP, Independent Registered Public Accounting Firm](exhibit231-deloittetouchel.htm)</u> |  |  |  |  | X |
| 23.2 | <u>[Consent of Fenwick & West LLP (contained in Exhibit 5.1)](exhibit51-opinionoffenwick.htm)</u> |  |  |  |  | X |
| 24.1 | <u>[Power of Attorney (included on the signature page to this Registration Statement)](#i8ca4da5df4d34a2a889465c8c5052fc4_13)</u> |  |  |  |  | X |
| 99.1 | <u>[Amended and Restated 2014 Equity Incentive Plan, as amended](https://www.sec.gov/Archives/edgar/data/0001404644/000162828021010230/ex-101amendedandrestated20.htm)</u> | 8-K | 001-36327 | 10.1 | May 14, 2021 |  |
| 99.2 | <u>[Forms of Option Agreement and Option Grant Notice for Registrant's 2014 Equity Incentive Plan](https://www.sec.gov/Archives/edgar/data/1404644/000119312514024524/d619679dex104.htm)</u> | S-1 | 333-193615 | 10.4 | January 28, 2014 |  |
| 99.3 | <u>[Restricted Stock Unit Grant Notice for Registrant's 2014 Equity Incentive Plan](https://www.sec.gov/Archives/edgar/data/1404644/000156459020039671/nltx-ex102_301.htm)</u>  | 10-Q | 001-36327 | 10.2 | August 12, 2020 |  |
| 107 | <u>[Filing Fee Table](exhibit107filingfeetablefo.htm)</u> |  |  |  |  | X |

---

------

**ITEM 9.&nbsp;&nbsp;&nbsp;&nbsp;UNDERTAKINGS**

A. The undersigned registrant hereby undertakes:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**(1)** To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**(i)** To include any prospectus required by Section 10(a)(3) of the Securities Act;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**(ii)** To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement.

Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20% change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective registration statement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**(iii)** To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement;

<u>provided,</u> <u>however</u>*,* that paragraphs (A)(1)(i) and (A)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in the registration statement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**(2)** That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered herein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**(3)** To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

**B.** The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the Registration Statement shall be deemed to be a new registration statement relating to the securities offered herein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

**C.** Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.

------

**SIGNATURES** 

Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Seattle, Washington on this 20th day of March, 2023.

---

| | |
|:---|:---|
| **NEOLEUKIN THERAPEUTICS, INC.** | **NEOLEUKIN THERAPEUTICS, INC.** |
| By: | /s/ Jonathan G. Drachman, M.D. |
|  | Jonathan G. Drachman, M.D. |
|  | *President and Chief Executive Officer* |

---

**POWER OF ATTORNEY** 

**KNOW ALL PERSONS BY THESE PRESENTS**, that each person whose signature appears below constitutes and appoints Jonathan G. Drachman and Sean Smith, and each of them, as his true and lawful attorneys-in-fact and agents, each with the full power of substitution, for him and in his name, place or stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or their, his or her substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated:

---

| | | |
|:---|:---|:---|
| **Signature** | **Title** | **Date** |
| /s/ Jonathan G. Drachman, M.D. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;President, Chief Executive Officer and Director<br>*(Principal Executive and Financial Officer)* | March 20, 2023 |
| Jonathan G. Drachman, M.D. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;President, Chief Executive Officer and Director<br>*(Principal Executive and Financial Officer)* | March 20, 2023 |
| /s/ Sean Smith | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Vice President, Finance<br>*(Principal Accounting Officer)* | March 20, 2023 |
| Sean Smith | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Vice President, Finance<br>*(Principal Accounting Officer)* | March 20, 2023 |
| /s/ Martin Babler | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Director | March 20, 2023 |
| Martin Babler |  |  |
| /s/ M. Cantey Boyd | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Director | March 20, 2023 |
| M. Cantey Boyd |  |  |
| /s/ Erin Lavelle | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Director | March 20, 2023 |
| Erin Lavelle |  |  |
| /s/ Sarah B. Noonberg, M.D., Ph.D. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Director | March 20, 2023 |
| Sarah B. Noonberg, M.D., Ph.D. |  |  |
| /s/ Todd Simpson | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Director | March 20, 2023 |
| Todd Simpson |  |  |
| /s/ Rohan Palekar | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Director | March 20, 2023 |
| Rohan Palekar |  |  |

---

## Ex-Filing

**Exhibit 107**

Calculation Of Filing Fee Tables<br>

Form S-8<br>(Form Type)<br>

Neoleukin Therapeutics, Inc.

(Exact Name of Registrant as Specified in its Charter)

Table 1: Newly Registered Securities

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| Security Type | Security Class Title | Fee Calculation Rule | Amount Registered(1) | Proposed Maximum Offering Price Per Unit | Maximum Aggregate Offering Price | Fee Rate | Amount of Registration Fee |
| Equity | Common stock, par value $0.000001 per share | Rule 457(c) and Rule 457(h) | 2212454(2) | $0.63(3) | $1393847 | $0.00011020 | $154 |
| **Total Offering Amounts** | **Total Offering Amounts** | **Total Offering Amounts** | **Total Offering Amounts** |  | **$1393847** |  | **$154** |
| **Total Fees Previously Paid** | **Total Fees Previously Paid** | **Total Fees Previously Paid** | **Total Fees Previously Paid** |  |  |  | **-** |
| **Total Fee Offsets** | **Total Fee Offsets** | **Total Fee Offsets** | **Total Fee Offsets** |  |  |  | **-** |
| **Net Fee Due** | **Net Fee Due** | **Net Fee Due** | **Net Fee Due** |  |  |  | **$154** |

---

(1) Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "***Securities Act***"), this Registration Statement shall also cover any additional shares of the Registrant's common stock that becomes issuable in respect of the securities identified in the above table by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the receipt of consideration that increases the number of the Registrant's outstanding shares of common stock.

(2) Represents additional shares of common stock reserved for issuance under the Registrant's Amended and Restated 2014 Equity Incentive Plan, as amended and restated as of May 13, 2021.

(3) Estimated in accordance with Rule 457(c) and (h) under the Securities Act solely for the purpose of calculating the registration fee on the basis of $0.63, the average of the high and low prices of the Registrant's common stock as reported on The Nasdaq Global Market on March 15, 2023.

## Exhibit 5.1

**Exhibit 5.1**

March 20, 2023

Neoleukin Therapeutics, Inc.

188 East Blaine Street, Suite 450

Seattle, Washington 98102

Re: Registration Statement on Form S-8

Ladies and Gentlemen:

As counsel to Neoleukin Therapeutics, Inc., a Delaware corporation (the "***Company***"), we have examined the Registration Statement on Form S-8 (the "***Registration Statement***") to be filed by the Company with the Securities and Exchange Commission (the "***Commission***") on or about March 20, 2023 in connection with the registration under the Securities Act of 1933, as amended (the "***Securities Act***"), of an aggregate of 2,212,454 shares (the "***Shares***") of the Company's Common Stock, $0.000001 par value per share (the "***Common Stock***"), that consists of the exercise or settlement of awards (including awards of stock options, restricted stock, stock bonuses, stock appreciation rights, restricted stock units and/or performance shares) to be granted under the Company's Amended and Restated 2014 Equity Incentive Plan (the "***Plan***").

As to matters of fact relevant to the opinions rendered herein, we have examined such documents, certificates and other instruments which we have deemed necessary or advisable, including a certificate addressed to us and dated the date hereof executed by the Company (the "***Opinion Certificate***"). We have not undertaken any independent investigation to verify the accuracy of any such information, representations or warranties or to determine the existence or absence of any fact, and no inference as to our knowledge of the existence or absence of any fact should be drawn from our representation of the Company or the rendering of the opinion set forth below. We have not considered parol evidence in connection with any of the agreements or instruments reviewed by us in connection with this letter.

In our examination of documents for purposes of this letter, we have assumed, and express no opinion as to, the genuineness and authenticity of all signatures on original documents, the authenticity and completeness of all documents submitted to us as originals, that each document is what it purports to be, the conformity to originals of all documents submitted to us as copies or facsimile copies, the absence of any termination, modification or waiver of or amendment to any document reviewed by us (other than as has been disclosed to us), the legal competence or capacity of all persons or entities (other than the Company) executing the same and (other than the Company) the due authorization, execution and delivery of all documents by each party thereto. We have also assumed the conformity of the documents filed with the Commission via the Electronic Data Gathering, Analysis and Retrieval System ("***EDGAR***"), except for required EDGAR formatting changes, to physical copies submitted for our examination.

The opinions in this letter are limited to the existing General Corporation Law of the State of Delaware now in effect. We express no opinion with respect to any other laws.

Based upon, and subject to, the foregoing, it is our opinion that the Shares, when issued and sold by the Company in accordance with the terms (including, without limitation, payment and authorization provisions) of the Plan and the form of award agreement thereunder, against the Company's receipt of payment therefor (in an amount and type of consideration not less than the par value per Share), and duly registered on the books of the transfer agent and registrar for the Shares in the name or on behalf of the holders thereof, will be validly issued, fully paid and non-assessable.

We consent to the use of this opinion as an exhibit to the Registration Statement and further consent to all references to us, if any, in the Registration Statement, the prospectuses constituting a part thereof and any amendments thereto. We do not thereby admit that we are within the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations of the Commission thereunder.

------

This opinion is intended solely for your use in connection with the issuance and sale of the Shares subject to the Registration Statement and is not to be relied upon for any other purpose. In providing this letter, we are opining only as to the specific legal issues expressly set forth above, and no opinion shall be inferred as to any other matter or matters. This opinion is rendered on, and speaks only as of, the date of this letter first written above, and does not address any potential change in facts or law that may occur after the date of this opinion letter. We assume no obligation to advise you of any fact, circumstance, event or change in the law or the facts that may hereafter be brought to our attention, whether or not such occurrence would affect or modify any of the opinions expressed herein.

Very truly yours,

<u>/s/ FENWICK & WEST LLP</u>

Fenwick & West LLP

2&nbsp;&nbsp;&nbsp;&nbsp;

## Exhibit 23.1

**Exhibit 23.1**

**CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM**

We consent to the incorporation by reference in this Registration Statement on Form S-8 of our report dated March 20, 2023, relating to the financial statements of Neoleukin Therapeutics, Inc. appearing in the Annual Report on Form 10-K of Neoleukin Therapeutics, Inc. for the year ended December 31, 2022.

/s/ Deloitte & Touche LLP

Seattle, Washington

March 20, 2023

<br>