# EDGAR Filing Document

**Accession Number:** 0001808805
**File Stem:** 0001808805-23-000005
**Filing Date:** 2023-2
**Character Count:** 17923
**Document Hash:** 46f7d05da1b2660f35018ed5ced3f3cb
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001808805-23-000005.hdr.sgml**: 20230223

**ACCESSION NUMBER**: 0001808805-23-000005

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 13

**CONFORMED PERIOD OF REPORT**: 20230223

**ITEM INFORMATION**: Results of Operations and Financial Condition

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20230223

**DATE AS OF CHANGE**: 20230222

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Nautilus Biotechnology, Inc.
- **CENTRAL INDEX KEY:** 0001808805
- **STANDARD INDUSTRIAL CLASSIFICATION:** LABORATORY ANALYTICAL INSTRUMENTS [3826]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-39434
- **FILM NUMBER:** 23654816

**BUSINESS ADDRESS:**
- **STREET 1:** 2701 EASTLAKE AVE EAST
- **CITY:** SEATTLE
- **STATE:** WA
- **ZIP:** 98102
- **BUSINESS PHONE:** 206-333-2001

**MAIL ADDRESS:**
- **STREET 1:** 2701 EASTLAKE AVE EAST
- **CITY:** SEATTLE
- **STATE:** WA
- **ZIP:** 98102

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ARYA Sciences Acquisition Corp III
- **DATE OF NAME CHANGE:** 20200408

?xml version="1.0" ? naut-20230223

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**FORM 8-K**

**CURRENT REPORT**

**Pursuant to Section 13 or 15(d) of the**

**Securities Exchange Act of 1934**

**Date of Report (Date of earliest event reported): February 23, 2023**

**NAUTILUS BIOTECHNOLOGY, INC.**

(Exact name of registrant as specified in its charter)

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| | | |
|:---|:---|:---|
| **Delaware**<br>(State or other jurisdiction<br>of incorporation) | **001-39434** <br>(Commission File Number) | **98-1541723**<br>(I.R.S. Employer<br>Identification No.) |

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| | |
|:---|:---|
| **2701 Eastlake Avenue East**<br>**Seattle, Washington**<br>(Address of principal executive offices) | **98102**<br>(Zip code) |

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**(206) 333-2001**

(Registrant's telephone number, including area code)

(Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

□ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

□ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

□ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

□ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

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| | | |
|:---|:---|:---|
| Title of each class | Trading Symbol(s) | Name of each exchange on which registered |
| **Common Stock, par value $0.0001 per share** | **NAUT** | **The Nasdaq Stock Market LLC** |

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Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ⌧

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. □

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**Item 2.02.&nbsp;&nbsp;&nbsp;&nbsp;Results of Operations and Financial Condition.** 

On February 23, 2023, Nautilus Biotechnology, Inc. issued a press release reporting its financial results for the quarter and fiscal year ended December 31, 2022. A copy of the press release is furnished herewith as Exhibit 99.1 to this Current Report on Form 8-K.

The information furnished in this Current Report under Item 2.02 and the exhibit attached hereto shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such a filing.

**Item 9.01.&nbsp;&nbsp;&nbsp;&nbsp;Financial Statements and Exhibits.** 

**(d)&nbsp;&nbsp;&nbsp;&nbsp;Exhibits** 

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| | |
|:---|:---|
| **Exhibit**<br>**Number** | **Description** |
| <u>[99.1](exhibit991-2022annualrepor.htm)</u> | <u>[Press Release dated](exhibit991-2022annualrepor.htm)[February](exhibit991-2022annualrepor.htm)[2](exhibit991-2022annualrepor.htm)[3](exhibit991-2022annualrepor.htm)[, 202](exhibit991-2022annualrepor.htm)[3](exhibit991-2022annualrepor.htm)[.](exhibit991-2022annualrepor.htm)</u> |
| 104 | Cover page Interactive Data File (embedded with the Inline XBRL document) |

---

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**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Dated: February 23, 2023

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| | |
|:---|:---|
| **NAUTILUS BIOTECHNOLOGY, INC.** | **NAUTILUS BIOTECHNOLOGY, INC.** |
| By: | /s/ Sujal Patel |
| Name: | Sujal Patel |
| Title: | Chief Executive Officer |

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## Exhibit 99.1

**Exhibit 99.1**

**Nautilus Biotechnology Reports Fourth Quarter and Fiscal Year 2022 Financial Results**

**SEATTLE, WA, February 23, 2023** – Nautilus Biotechnology, Inc. (NASDAQ: NAUT; or "Nautilus"), a company pioneering a single molecule proteome analysis platform, today reported financial results for the fourth quarter and fiscal year ended December 31, 2022.

**Recent Highlights**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Announced a strategic partnership with the Translational Genomics Research Institute (TGen) to explore the utility of the Nautilus platform for studying specific protein targets in diffuse intrinsic pontine glioma (DIPG), a rare and often fatal childhood cancer.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Presented a poster at the HUPO World Congress that demonstrated decoding of a model protein from an experiment of several dozen multi-affinity probes across 70 cycles.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Announced an expansion of Nautilus' geographic footprint with the opening of an office in San Diego's University Town Center, one of the largest and most talent-rich biotechnology and pharmaceutical hubs in the country.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Reported Q4 2022 expenses below peak spending levels reached in Q4 of the prior year, helping to maintain cash runway well into 2025.

"We made good progress on key scientific and business objectives in 2022 despite challenging macroeconomic conditions", said Sujal Patel, CEO of Nautilus. "We presented scientific posters throughout the year that articulated key elements of our single-molecule approach to proteomics, strengthened the core leadership of our R&D team, and dramatically expanded our development organization, all while tightly and successfully managing operating expenses. We very much look forward to building on the successes of 2022 as we move through 2023 on our way to a commercial launch and beyond."

**Fiscal Year 2022 Financial Results**

Operating expenses were $63.6 million for the year-ended December 31, 2022, a $13.1 million or 26% increase from $50.5 for the year ended December 31, 2021. The increase in operating expenses was driven primarily by an increase in headcount to support ongoing development of our products as well as the costs associated with being a public company.

Net loss was $57.9 million for the year-ended December 31, 2022, as compared to a net loss of $50.3 million for the corresponding prior year period.

Cash, cash equivalents, and investments were $313.6 million as of December 31, 2022.

**Webcast and Conference Call Information**

Nautilus will host a conference call to discuss the fourth quarter and fiscal year 2022 financial results, business developments and outlook before market open on Thursday, February 23, 2023 at 5:30 AM Pacific Time / 8:30 AM Eastern Time. Live audio of the webcast will be available on the "Investors" section of the company website at: <u>www.nautilus.bio</u>.

**About Nautilus Biotechnology, Inc.**

Based in Seattle, Washington, Nautilus is a development stage life sciences company creating a platform technology for quantifying and unlocking the complexity of the proteome. Nautilus' mission is to transform the field of proteomics by democratizing access to the proteome and enabling fundamental advancements across human health and medicine. To learn more about Nautilus, visit www.nautilus.bio

**Special Note Regarding Forward-Looking Statements**

This press release contains forward-looking statements within the meaning of federal securities laws. Forward-looking statements in this press release include, but are not limited to, statements regarding Nautilus' expectations regarding the company's business operations, financial performance and results of operations; expectations with respect to any revenue timing or projections, expectations with respect to the timing of the launch of Nautilus' product platform and full commercial availability, the functionality and performance of Nautilus' product platform, its potential impact on providing proteome access, pharmaceutical development and drug discovery, expanding research horizons, and enabling scientific explorations and discovery, and the present and future capabilities and limitations of emerging proteomics technologies. These statements are based on numerous assumptions concerning the development of Nautilus' products, target markets, and other current and

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emerging proteomics technologies, and involve substantial risks, uncertainties and other factors that may cause actual results to be materially different from the information expressed or implied by these forward-looking statements. Risks and uncertainties that could materially affect the accuracy of Nautilus' assumptions and its ability to achieve the forward-looking statements set forth in this press release include (without limitation) the following: Nautilus' product platform is not yet commercially available and remains subject to significant scientific and technical development, which is inherently challenging and difficult to predict, particularly with respect to highly novel and complex products such as those being developed by Nautilus. Even if our development efforts are successful, our product platform will require substantial validation of its functionality and utility in life science research. In the course of Nautilus' scientific and technical development and associated product validation and commercialization, we may experience material delays as a result of unanticipated events. We cannot provide any guarantee or assurance with respect to the outcome of our development, collaboration, and commercialization initiatives or with respect to their associated timelines. For a more detailed description of additional risks and uncertainties facing Nautilus and its development efforts, investors should refer to the information under the caption "Risk Factors" in our Annual Report on Form 10-K to be filed for the year ended December 31, 2022. The forward-looking statements in this press release are as of the date of this press release. Except as otherwise required by applicable law, Nautilus disclaims any duty to update any forward-looking statements. You should, therefore, not rely on these forward-looking statements as representing our views as of any date subsequent to the date of this press release.

**Disclosure Information** 

Nautilus uses filings with the Securities and Exchange Commission, its website (www.nautilus.bio), press releases, public conference calls, public webcasts, and its social media accounts as means of disclosing material non-public information and for complying with Regulation FD. Therefore, Nautilus encourages investors, the media, and others interested in Nautilus to review the information it makes public in these locations, as such information could be deemed to be material information.

**Media Contact**

press@nautilus.bio

**Investor Contact**

investorrelations@nautilus.bio

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**Nautilus Biotechnology, Inc.** <br>**Consolidated Balance Sheets** <br>**As of December 31, 2022 and 2021 (Unaudited)**<br>

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| | | |
|:---|:---|:---|
| *(in thousands)* | **December 31,<br>2022** | **December 31,<br>2021** |
| **Assets** |  |  |
| Current assets: |  |  |
| &nbsp;&nbsp;Cash and cash equivalents | $114523 | $185619 |
| &nbsp;&nbsp;Short-term investments | 69948 | 160110 |
| &nbsp;&nbsp;Prepaid expenses and other current assets | 2738 | 3493 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total current assets | 187209 | 349222 |
| Property and equipment, net | 3700 | 2483 |
| Operating lease right-of-use assets | 28866 | 29377 |
| Long-term investments | 129169 | 16371 |
| Other long-term assets | 1108 | 997 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total assets | $350052 | $398450 |
| **Liabilities and Stockholders' Equity** |  |  |
| Current liabilities: |  |  |
| &nbsp;&nbsp;Accounts payable | $1272 | $1723 |
| &nbsp;&nbsp;Accrued expenses and other liabilities | 3528 | 3119 |
| &nbsp;&nbsp;Current portion of operating lease liability | 1991 | 970 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total current liabilities | 6791 | 5812 |
| &nbsp;&nbsp;Operating lease liability, net of current portion | 28337 | 29062 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total liabilities | 35128 | 34874 |
| Stockholders' equity: |  |  |
| &nbsp;&nbsp;Preferred stock |  |  |
| &nbsp;&nbsp;Common stock | 12 | 12 |
| &nbsp;&nbsp;Additional paid-in capital | 455330 | 444388 |
| &nbsp;&nbsp;Accumulated other comprehensive loss | (1854) | (184) |
| &nbsp;&nbsp;Accumulated deficit | (138564) | (80640) |
| &nbsp;&nbsp;&nbsp;&nbsp;Total stockholders' equity | 314924 | 363576 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total liabilities and stockholders' equity | $350052 | $398450 |

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**Nautilus Biotechnology, Inc.** <br>**Consolidated Statements of Operations** <br>**Three Months and Year Ended December 31, 2022 and 2021 (Unaudited)**<br>

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| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended December 31,** | **Three Months Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
| *(in thousands, except share and per share amounts)* | **2022** | **2021** | **2022** | **2021** |
| Operating expenses: |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Research and development | $9587 | $9893 | $37672 | $29352 |
| &nbsp;&nbsp;&nbsp;General and administrative | 6717 | 6923 | 25946 | 21146 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total operating expenses | 16304 | 16816 | 63618 | 50498 |
| Other income (expense): |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Interest income | 2887 | 160 | 5816 | 329 |
| &nbsp;&nbsp;&nbsp;Other expense | 8 | (33) | (122) | (146) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total other income | $2895 | $127 | $5694 | $183 |
| Net loss | $(13409) | $(16689) | $(57924) | $(50315) |
| Net loss per share attributable to common stockholders, basic and diluted | $(0.11) | $(0.13) | $(0.46) | $(0.60) |
| Weighted-average shares used in computing net loss per share attributable to common stockholders, basic and diluted <sup>(1)</sup> | 124789542 | 124232794 | 124589555 | 84464081 |

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) The weighted-average number of shares of Common Stock outstanding prior to the Business Combination have been retroactively restated to reflect the exchange ratio of approximately 3.6281 established in the Business Combination.

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**Nautilus Biotechnology, Inc.** <br>**Consolidated Statements of Cash Flows** <br>**Year Ended December 31, 2022 and 2021 (Unaudited)**<br>

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| | | |
|:---|:---|:---|
| *(in thousands)* | **Year Ended December 31, 2022** | **Year Ended December 31, 2021** |
| **Cash flows from operating activities** |  |  |
| Net loss | $(57924) | $(50315) |
| Adjustments to reconcile net loss to net cash used in operating activities |  |  |
| &nbsp;&nbsp;Stock-based compensation | 10380 | 7934 |
| &nbsp;&nbsp;Amortization of operating lease right-of-use assets | 2199 | 1823 |
| &nbsp;&nbsp;Depreciation | 1217 | 1019 |
| &nbsp;&nbsp;Amortization (accretion) of premiums (discount) on securities, net | (890) | 183 |
| &nbsp;&nbsp;Changes in operating assets and liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Prepaid expenses and other assets | 756 | (2750) |
| &nbsp;&nbsp;&nbsp;&nbsp;Accounts payable | (561) | 1261 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accrued expenses and other liabilities | 409 | 2255 |
| &nbsp;&nbsp;&nbsp;&nbsp;Operating lease liabilities | (1392) | (788) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net cash used in operating activities | (45806) | (39241) |
| **Cash flows from investing activities** |  |  |
| Purchases of securities | (186591) | (221795) |
| Purchases of property and equipment | (2324) | (2269) |
| Proceeds from maturities of securities | 163175 | 85100 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net cash used in investing activities | (25740) | (138964) |
| **Cash flows from financing activities** |  |  |
| Proceeds from exercise of stock options | 330 | 167 |
| Proceeds from issuance of common stock under employee stock purchase plan | 232 |  |
| Net proceeds from reverse recapitalization and PIPE financing |  | 335409 |
| Payments of offering costs |  | (8129) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net (decrease) increase in cash, cash equivalents and restricted cash | (70984) | 149242 |
| Cash, cash equivalents and restricted cash at beginning of period | 186461 | 37219 |
| Cash, cash equivalents and restricted cash at end of period | $115477 | $186461 |

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