# EDGAR Filing Document

**Accession Number:** 0001400118
**File Stem:** 0001104659-26-026154
**Filing Date:** 2026-3
**Character Count:** 24536
**Document Hash:** ae4682e5a1d20a038c3f2470396a075c
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-26-026154.hdr.sgml**: 20260311

**ACCESSION NUMBER**: 0001104659-26-026154

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 15

**FILED AS OF DATE**: 20260311

**DATE AS OF CHANGE**: 20260311

**EFFECTIVENESS DATE**: 20260311

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Sagimet Biosciences Inc.
- **CENTRAL INDEX KEY:** 0001400118
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 205991472
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-294200
- **FILM NUMBER:** 26741572

**BUSINESS ADDRESS:**
- **STREET 1:** 155 BOVET RD., SUITE 303
- **CITY:** SAN MATEO
- **STATE:** CA
- **ZIP:** 94402
- **BUSINESS PHONE:** (650) 561-8600

**MAIL ADDRESS:**
- **STREET 1:** 155 BOVET RD., SUITE 303
- **CITY:** SAN MATEO
- **STATE:** CA
- **ZIP:** 94402

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** 3-V Biosciences, Inc.
- **DATE OF NAME CHANGE:** 20070521

**As filed with the Securities and Exchange Commission on March 11, 2026**

**Registration No. 333-**

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**FORM S-8**

**REGISTRATION STATEMENT**

***Under***

***The Securities Act of 1933***

**SAGIMET BIOSCIENCES INC.**

**(Exact name of registrant as specified in its charter)**

---

| | |
|:---|:---|
| **Delaware** | **20-5991472** |
| **(State or other jurisdiction of**<br> **incorporation or organization)** | **(I.R.S. Employer**<br> **Identification No.)** |

---

**155 Bovet Road, Suite 303**

**San Mateo, CA 94402**

**(650) 561-8600**

**(Address, including zip code and telephone number, including area code, of Registrant's principal executive offices)**

**Sagimet Biosciences Inc. 2023 Stock Option and Incentive Plan**

 **Sagimet Biosciences Inc. 2023 Employee Stock Purchase Plan**

**(Full title of the plans)**

**David Happel**

**President and Chief Executive Officer**

**Sagimet Biosciences Inc.**

**155 Bovet Road, Suite 303**

**San Mateo, CA 94402**

**(650) 561-8600**

**(Name, address, including zip code, and telephone number, including area code, of agent for service)**

***Copies to:***

**Rachael M. Bushey<br> Jennifer Porter**

**Goodwin Procter LLP**

**3025 John F Kennedy Blvd**

**Philadelphia, PA 19104**

**(445) 207-7805**

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ◻ | Accelerated filer | ◻ |
| Non-accelerated filer | ⌧ | Smaller reporting company | ⌧ |
|  |  | Emerging growth company | ⌧ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ◻

**EXPLANATORY NOTE**

This Registration Statement on Form S-8 is being filed for the purpose of (i) registering an additional 1,278,164 shares of Series A common stock, $0.0001 par value per share (the "<u>Common Stock</u>"), of Sagimet Biosciences Inc. (the "<u>Registrant</u>") under the Sagimet Biosciences Inc. 2023 Stock Option and Incentive Plan (the "<u>2023 Plan</u>"), which were added on January 1, 2026 as a result of an automatic annual increase provision therein, and (ii) registering an additional 215,497 shares of Common Stock under the Sagimet Biosciences Inc. Amended and Restated 2023 Employee Stock Purchase Plan (the "<u>2023 ESPP</u>"), which were added on January 1, 2026 as a result of an automatic annual increase provision therein. for which a Registration Statement on Form S-8 relating to the same employee benefit plans is effective.

These additional shares of Common Stock are of the same class as other securities for which the Registrant's Registration Statements on Form S-8 (File Nos. 333-273276, 333-278196 and 333-285731) filed with the Securities and Exchange Commission ("<u>Commission</u>") on July 17, 2023, March 25, 2024 and March 12, 2025 are effective.

Pursuant to General Instruction E to Form S-8, the contents of the Registration Statement on Form S-8 (File Nos. 333-273276, 333-278196, 333-285731) filed with the Commission on [July 17, 2023](https://www.sec.gov/Archives/edgar/data/1400118/000110465923081410/tm2321201d1_s8.htm), [March 25, 2024](https://www.sec.gov/Archives/edgar/data/1400118/000110465924038136/tm249422d1_s8.htm) and [March 12, 2025](https://www.sec.gov/Archives/edgar/data/1400118/000110465925022790/tm258742d2_s-8.htm) are incorporated herein by reference except to the extent supplemented, amended or superseded by the information set forth herein. Only those items of Form S-8 containing new information not contained in the earlier registration statement are presented herein.

**Part I**

**INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS**

**Item 1.** **Plan Information.** 

The information specified in Part I of Form S-8 is omitted from this filing in accordance with the provisions of Rule 428 under the Securities Act and the introductory note to Part I of the Form S-8 instructions. The documents containing the information specified in Part I will be delivered to the participants in the 2023 Plan and the 2023 ESPP as required by Rule 428(b)(1) under the Securities Act.

**Item 2.** **Registrant Information and Employee Plan Annual Information.** 

The documents containing the information specified in this Item 2 will be sent or given to participants as specified by Rule 428(b)(1) under the Securities Act. In accordance with the rules and regulations of the Commission and the instructions to Form S-8, such documents are not being filed with the Commission either as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424 under the Securities Act.

**PART II<br> INFORMATION REQUIRED IN THE REGISTRATION STATEMENT**

**Item 3.** **Incorporation of Documents by Reference.**

The following documents of the Registrant, filed or to be filed with the Commission, are incorporated by reference in this Registration Statement as of their respective dates:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) The Registrant's [Annual Report on Form 10-K for the fiscal year ended December 31, 2025, filed with the Commission on March 11, 2026](https://www.sec.gov/ix?doc=/Archives/edgar/data/1400118/000110465926026140/sgmt-20251231x10k.htm);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the description of the Registrant's Common Stock contained in the Company's Registration Statement on [Form 8-A (File No. 001-41742) filed with the Commission on July 11, 2023](https://www.sec.gov/Archives/edgar/data/1400118/000110465923079973/tm237052d18_8a12b.htm), together with any amendment thereto filed with the Commission for the purpose of updating such description; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) all documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), prior to the filing of a post-effective amendment to this Registration Statement, which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference into this Registration Statement; provided, however, that documents, reports and definitive proxy or information statements, or portions thereof, which are furnished and not filed in accordance with the rules of the Commission shall not be deemed incorporated by reference into this Registration Statement.

Any statement contained herein or in a document, all or a portion of which is incorporated or deemed to be incorporated by reference herein, shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or amended, to constitute a part of this Registration Statement.

**Item 8.** **Exhibits.**

The following documents are filed as exhibits to this Registration Statement:

**EXHIBIT INDEX**

---

| | |
|:---|:---|
| **Exhibit<br> No.** | **Description** |
| [4.1](https://www.sec.gov/Archives/edgar/data/1400118/000110465923082006/tm237052d22_ex3-1.htm) | [Eleventh Amended and Restated Certificate of Incorporation of Sagimet Biosciences Inc. (Incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-41742) filed on July 18, 2023).](https://www.sec.gov/Archives/edgar/data/1400118/000110465923082006/tm237052d22_ex3-1.htm) |
| [4.2](https://www.sec.gov/Archives/edgar/data/1400118/000110465923082006/tm237052d22_ex3-2.htm) | [Second Amended and Restated Bylaws of Sagimet Biosciences Inc. (Incorporated by reference to Exhibit 3.2 to the Registrant's Current Report on Form 8-K, as amended (File No. 001-41742) filed on July 18, 2023).](https://www.sec.gov/Archives/edgar/data/1400118/000110465923082006/tm237052d22_ex3-2.htm) |
| [4.3](https://www.sec.gov/Archives/edgar/data/1400118/000110465923074215/tm237052d7_ex4-1.htm) | [Form of Series A Common Stock Certificate of Sagimet Biosciences Inc. (Incorporated by reference to Exhibit 4.1 to the Company's Registration Statement on Form S-1 (File No. 333-272901) filed on June 23, 2023).](https://www.sec.gov/Archives/edgar/data/1400118/000110465923074215/tm237052d7_ex4-1.htm) |
| [5.1\*](tm268373d2_ex5-1.htm) | [Opinion of Goodwin Procter LLP.](tm268373d2_ex5-1.htm) |
| [23.1\*](tm268373d2_ex23-1.htm) | [Consent of KPMG LLP, independent registered public accounting firm.](tm268373d2_ex23-1.htm) |
| [23.2\*](tm268373d2_ex5-1.htm) | [Consent of Goodwin Procter LLP (included in Exhibit 5.1).](tm268373d2_ex5-1.htm) |

---

---

| | |
|:---|:---|
| [24.1\*](#a_001) | [Power of Attorney (included on signature page).](#a_001) |
| [99.1](https://www.sec.gov/Archives/edgar/data/1400118/000110465923074215/tm237052d7_ex10-5.htm) | [Sagimet Biosciences Inc. 2023 Stock Option and Incentive Plan (Incorporated by reference to Exhibit 10.5 to the Registrant's Registration Statement on Form S-1, as amended (File No. 333-272901)).](https://www.sec.gov/Archives/edgar/data/1400118/000110465923074215/tm237052d7_ex10-5.htm) |
| [99.2](https://www.sec.gov/Archives/edgar/data/1400118/000110465923074215/tm237052d7_ex10-6.htm) | [Forms of Incentive Stock Option Agreement, Non-Qualified Stock Option Agreement for Non-Employee Directors and Non-Qualified Stock Option Agreement for Company Employees under the Sagimet Biosciences Inc. 2023 Stock Option and Incentive Plan under the Sagimet Biosciences Inc. 2023 Stock Option and Incentive Plan (Incorporated by reference to Exhibit 10.6 to the Registrant's Registration Statement on Form S-1, as amended (File No. 333-272901)).](https://www.sec.gov/Archives/edgar/data/1400118/000110465923074215/tm237052d7_ex10-6.htm) |
| [99.3](https://www.sec.gov/Archives/edgar/data/1400118/000110465923074215/tm237052d7_ex10-7.htm) | [Forms of Restricted Stock Unit Award Agreement for Non-Employee Directors and Restricted Stock Unit Award Agreement for Company Employees under the Sagimet Biosciences Inc. 2023 Stock Option and Incentive Plan (Incorporated by reference to Exhibit 10.7 to the Registrant's Registration Statement on Form S-1, as amended (File No. 333-272901)).](https://www.sec.gov/Archives/edgar/data/1400118/000110465923074215/tm237052d7_ex10-7.htm) |
| [99.4](https://www.sec.gov/Archives/edgar/data/1400118/000110465923074215/tm237052d7_ex10-8.htm) | [Form of Restricted Stock Award Agreement under the Sagimet Biosciences Inc. 2023 Stock Option and Incentive Plan (Incorporated by reference to Exhibit 10.8 to the Registrant's Registration Statement on Form S-1, as amended (File No. 333-272901)).](https://www.sec.gov/Archives/edgar/data/1400118/000110465923074215/tm237052d7_ex10-8.htm) |
| [99.5](https://www.sec.gov/Archives/edgar/data/1400118/000110465923074215/tm237052d7_ex10-9.htm) | [Sagimet Biosciences Inc. Amended and Restated 2023 Employee Stock Purchase Plan (Incorporated by reference to Exhibit 10.9 to the Registrant's Annual Report on Form 10-K (File No. 001-41742)).](https://www.sec.gov/Archives/edgar/data/1400118/000110465923074215/tm237052d7_ex10-9.htm) |
| [107\*](tm268373d2_ex-filingfees.htm) | [Filing fee table.](tm268373d2_ex-filingfees.htm) |

---

\*Filed herewith.

**SIGNATURES**

Pursuant to the requirements of the Securities Act, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Mateo, State of California, on this 11<sup>th</sup> day of March, 2026.

---

| | |
|:---|:---|
| **SAGIMET BIOSCIENCES INC.** | **SAGIMET BIOSCIENCES INC.** |
| By: | /s/ David Happel |
|  | Name: David Happel |
|  | Title: President, Chief Executive Officer and Director |

---

**POWER OF ATTORNEY AND SIGNATURES**

KNOW ALL BY THESE PRESENT, that each individual whose signature appears below hereby constitutes and appoints each of David Happel and Thierry Chauche, as such person's true and lawful attorney-in-fact and agent with full power of substitution and resubstitution, for such person in such person's name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and all documents in connection therewith, with the Commission granting unto each said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as such person might or could do in person, hereby ratifying and confirming all that any said attorney-in-fact and agent, or any substitute or substitutes of any of them, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following person in the capacities and on the date indicated.

---

| | | |
|:---|:---|:---|
| **NAME** | **TITLE** | **DATE** |
| /s/ David Happel | President, Chief Executive Officer and Director | March 11, 2026 |
| David Happel | *Principal Executive Officer* |  |
| /s/ Thierry Chauche | Chief Financial Officer |  |
| Thierry Chauche | *Principal Financial and Accounting Officer* | March 11, 2026 |
| /s/ George Kemble, Ph.D. | Chairman of the Board | March 11, 2026 |
| George Kemble, Ph.D. |  |  |
| /s/ Elizabeth Grammer, Esq. | Director | March 11, 2026 |
| Elizabeth Grammer, Esq. |  |  |
| /s/ Jennifer Jarrett | Director | March 11, 2026 |
| Jennifer Jarrett |  |  |
| /s/ Beth Seidenberg, M.D. | Director | March 11, 2026 |
| Beth Seidenberg, M.D. |  |  |
| /s/ Anne Phillips, M.D. | Director | March 11, 2026 |
| Anne Phillips, M.D. |  |  |

---

## Exhibit 5.1

**Exhibit 5.1**

![](tm268373d2_ex5-1img001.jpg)

March 11, 2026

Sagimet Biosciences Inc.

155 Bovet Road, Suite 303

San Mateo, CA 94402

Re: <u>Securities Being Registered under Registration Statement on Form S-8</u>

We have acted as counsel to you in connection with your filing of a Registration Statement on Form S-8 (the "Registration Statement") pursuant to the Securities Act of 1933, as amended (the "Securities Act"), on or about the date hereof relating to 1,278,164 shares of Series A common stock, par value $0.0001 per share (the "Common Stock"), of Sagimet Biosciences Inc. (the "Company"), all of which are issuable pursuant to Sagimet Biosciences Inc. 2023 Stock Option and Incentive Plan (the "2023 Plan"), as well as 215,497 shares of Common Stock (together, the "Shares"), all of which are issuable pursuant to the Sagimet Biosciences Inc. Amended and Restated 2023 Employee Stock Purchase Plan (the "2023 ESPP," together with the 2023 Plan, the "Plans").

We have reviewed such documents and made such examination of law as we have deemed appropriate to give the opinions set forth below. We have relied, without independent verification, on certificates of public officials and, as to matters of fact material to the opinion set forth below, on certificates and other inquiries of officers of the Company.

The opinion set forth below is limited to the Delaware General Corporation Law.

For purposes of the opinion set forth below, we have assumed that no event occurs that causes the number of authorized shares of Common Stock available for issuance by the Company to be less than the number of then unissued Shares.

Based on the foregoing, we are of the opinion that the Shares have been duly authorized and, upon issuance and delivery against payment therefor in accordance with the terms of the Plans, will be validly issued, fully paid and nonassessable.

This opinion letter and the opinion it contains shall be interpreted in accordance with the Core Opinion Principles as published in 74 *Business Lawyer* 815 (Summer 2019).

We hereby consent to the inclusion of this opinion as Exhibit 5.1 to the Registration Statement. In giving our consent, we do not admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations thereunder.

---

| |
|:---|
| Very truly yours, |
| /s/ Goodwin Procter LLP |
| GOODWIN PROCTER LLP |

---

## Exhibit 23.1

**Exhibit 23.1**

**CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM**

We consent to the use of our report dated March 11, 2026, with respect to the financial statements of Sagimet Biosciences Inc., incorporated herein by reference. The audit report of KPMG LLP on the aforementioned financial statements refers to adjustments to the 2024 financial statements to retrospectively adopt ASU 2023-09.

/s/ KPMG LLP

Philadelphia, Pennsylvania

March 11, 2026

## Ex-Filing

?xml version='1.0' encoding='ASCII'? EX-FILING FEES

---

| |
|:---|
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Calculation of Filing Fee Tables**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **S-8**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Sagimet Biosciences Inc.**  |

---

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Security Type**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Security Class Title**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Fee Calculation Rule**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Amount Registered**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Proposed Maximum Offering Price Per Unit**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Maximum Aggregate Offering Price**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Fee Rate**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Amount of Registration Fee**  |
| 1 | Equity | Series A Common Stock, par value $0.0001 | 457(a) | 1278164 | $5.41 | $6914867.24 | 0.0001381 | $954.94 |
| 2 | Equity | Series A Common Stock, par value $0.0001 | 457(a) | 215497 | $5.41 | $1165838.77 | 0.0001381 | $161.00 |
| Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: |  | $8080706.01  |  | $1115.94  |
| Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  |  |  |  | $0.00  |
| Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  |  |  |  | $1115.94  |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Offering Note** <br>

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <sup>1</sup> Note 1a. Pursuant to Rule 416(a) promulgated under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement also covers an indeterminate number of additional shares of common stock, par value $0.0001 (the "Common Stock") of Sagimet Biosciences Inc. (the "Registrant") issuable under the Sagimet Biosciences Inc. 2023 Stock Option and Incentive Plan (the "2023 Plan") and the Sagimet Biosciences Inc. Amended and Restated 2023 Employee Stock Purchase Plan (the "2023 ESPP") in the event the number of outstanding shares of the Registrant is increased by reason of any stock dividend, stock split, recapitalization, merger, consolidation or reorganization or similar transaction. Note 1b. Represents 1,278,164 shares of Common Stock that were added to the shares authorized for issuance under the 2023 Plan on January 1, 2026 pursuant to an "evergreen" provision contained in the 2023 Plan. Note 1c. Represents 215,497 shares of Common Stock that were added to the shares authorized for issuance under the 2023 ESPP on January 1, 2026 pursuant to an "evergreen" provision contained in the 2023 ESPP. Note 1d. This estimate is made pursuant to Rule 457(h) and Rule 457(c) of the Securities Act. The price shown is based upon the average of the high and low prices reported for the Common Stock on the Nasdaq Global Select Market on March 6, 2026. Note 1e. The Registrant does not have any fee offsets.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <sup>2</sup> See Note 1a. See Note 1b. See Note 1c. See Note 1d. See Note 1e.

---

| | |
|:---|:---|
| | |
| **Rule 457(p)** | **Rule 457(p)** |
| Fee Offset Claims | N/A |
| Fee Offset Sources | N/A |

---