# EDGAR Filing Document

**Accession Number:** 0001174940
**File Stem:** 0001493152-26-011684
**Filing Date:** 2026-3
**Character Count:** 12661
**Document Hash:** d01cdbf62c0ded01c8b138194433e9f6
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001493152-26-011684.hdr.sgml**: 20260319

**ACCESSION NUMBER**: 0001493152-26-011684

**CONFORMED SUBMISSION TYPE**: S-3/A

**PUBLIC DOCUMENT COUNT**: 2

**FILED AS OF DATE**: 20260319

**DATE AS OF CHANGE**: 20260319

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** ORAGENICS INC
- **CENTRAL INDEX KEY:** 0001174940
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 593410522
- **STATE OF INCORPORATION:** FL
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-3/A
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-292880
- **FILM NUMBER:** 26775282

**BUSINESS ADDRESS:**
- **STREET 1:** 9015 TOWN CENTER PARKWAY
- **STREET 2:** SUITE 143
- **CITY:** LAKEWOOD RANCH
- **STATE:** FL
- **ZIP:** 34202
- **BUSINESS PHONE:** 8132867900

**MAIL ADDRESS:**
- **STREET 1:** 9015 TOWN CENTER PARKWAY
- **STREET 2:** SUITE 143
- **CITY:** LAKEWOOD RANCH
- **STATE:** FL
- **ZIP:** 34202

**As filed with the Securities and Exchange Commission on March 19, 2026**

**Registration No. 333-292880** 

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549** 

**Pre-Effective Amendment No. 1 to**

**FORM S-3** 

**REGISTRATION STATEMENT** 

***UNDER***

***THE SECURITIES ACT OF 1933***

**ORAGENICS, INC.**

**(Exact name of registrant as specified in its charter)** 

---

| | |
|:---|:---|
| **Florida** | **59-3410522** |
| **(State or other jurisdiction of**<br> **incorporation or organization)** | **(I.R.S. Employer**<br> **Identification No.)** |

---

**9015 Town Center Parkway, Suite 143**

**Lakewood Ranch, Florida 34202**

**(813) 286-7900**

**(Address, including zip code, and telephone number, including area code, of principal executive offices)**

**Janet Huffman**

**Chief Executive Officer**

**Oragenics, Inc.**

**9015 Town Center Parkway, Suite 143**

**Lakewood Ranch, Florida 34202**

**(813) 286-7900**

**(Name, address, including zip code, and telephone number, including area code, of agent for service)**

***With copies to:***

**Mark A. Catchur, Esq.**

**Julio Esquivel, Esq.**

**Shumaker, Loop & Kendrick, LLP** 

**101 East Kennedy Boulevard, Suite 2800** 

**Tampa, Florida 33602** 

**Telephone: (813) 229-7600** 

**Approximate date of commencement of proposed sale to the public:** From time to time after this registration statement becomes effective.

If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box. **☐**

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box. **☒**

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. **☐**

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. **☐**

If this Form is a registration statement pursuant to General Instruction I.D. or a post-effective amendment thereto that shall become effective on filing with the Commission pursuant to Rule 462(e) under the Securities Act, check the following box. **☐**

If this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.D. filed to register additional securities or additional classes of securities pursuant to Rule 413(b) under the Securities Act, check the following box. **☐**

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | |
|:---|:---|
| Large accelerated filer **☐** | Accelerated filer **☐** |
| Non-accelerated filer **☒** | Smaller reporting company **☒** |
|  | Emerging growth company **☐** |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided to Section 7(a)(2)(B) of the Securities Act. **☐**

**The Registrant hereby amends this Registration Statement on such date or dates as may be necessary to delay its effective date until the Registrant shall file a further amendment which specifically states that the Registration Statement shall thereafter become effective in accordance with Section 8(A) of the Securities Act of 1933, or until this registration statement shall become effective on such date as the Commission, acting pursuant to Section 8(a), may determine.**

**EXPLANATORY NOTE**

We are filing this pre-effective amendment (the "Amendment") to our Registration Statement on Form S-3, as amended (File No. 333-292880), initially filed with the U.S. Securities and Exchange Commission (the "SEC") on January 22, 2026 (the "Registration Statement"), as an exhibits-only filing to file an updated auditor consent in Exhibit 23.1. Accordingly, this Amendment consists only of the facing page, this explanatory note, Item 16 of Part II of the Registration Statement, including the signature page and the exhibit index, and the filed exhibits. The prospectus is unchanged and has been omitted.

**Item 16. Exhibits and Financial Statement Schedules.** 

(a) Exhibit
 Index

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| **Exhibit**<br> **number** | **Exhibit description** | **Form** | **File no.** | **Exhibit** | **Filing date** | **Filed herewith** |
| 1.1\* | Form of Underwriting Agreement |  |  |  |  |  |
| 3.1 | [Amended and Restated Articles of Incorporation as amended prior to December 29, 2017 (including certificates of designation of Series A, B and C Preferred Stock)](https://www.sec.gov/Archives/edgar/data/1174940/000119312517383512/d515789dex31.htm) | 8-K | 001-32188 | 3.1 | 12/29/17 |  |
| 3.2 | [Articles of Amendment to Amended and Restated Articles of Incorporation dated effective December 29, 2017](https://www.sec.gov/Archives/edgar/data/1174940/000119312517383512/d515789dex32.htm) | 8-K | 001-32188 | 3.2 | 12/29/17 |  |
| 3.3 | [Articles of Amendment to Amended and Restated Articles of Incorporation effective January 19, 2018](https://www.sec.gov/Archives/edgar/data/1174940/000119312518014880/d481539dex31.htm) | 8-K | 001-32188 | 3.1 | 1/19/18 |  |
| 3.4 | [Articles of Amendment to Amended and Restated Articles of Incorporation](https://www.sec.gov/Archives/edgar/data/1174940/000119312518204110/d620404dex34.htm) | 8-K | 001-32188 | 3.4 | 6/26/18 |  |
| 3.5 | [Articles of Amendment to Amended and Restated Articles of Incorporation](https://www.sec.gov/Archives/edgar/data/1174940/000149315222005606/ex3-5.htm) | 8-K | 001-32188 | 3.5 | 2/28/22 |  |
| 3.6 | [Articles of Amendment to Amended and Restated Articles of Incorporation](https://www.sec.gov/Archives/edgar/data/1174940/000149315223002194/ex3-1.htm) | 8-K | 001-32188 | 3.1 | 1/23/2023 |  |
| 3.7 | [Articles of Amendment to Amended and Restated Articles of Incorporation](https://www.sec.gov/Archives/edgar/data/1174940/000149315223026968/ex3-1.htm) | 8-K | 001-32188 | 3.1 | 8/7/2023 |  |
| 3.8 | [Articles of Amendment to Amended and Restated Articles of Incorporation](https://www.sec.gov/Archives/edgar/data/1174940/000149315223044220/ex3-1.htm) | 8-K | 001-32188 | 3.1 | 12/8/2023 |  |
| 3.9 | [Articles of Amendment to Amended and Restated Articles of Incorporation](https://www.sec.gov/Archives/edgar/data/1174940/000149315223045030/ex3-1.htm) | 8-K | 001-32188 | 3.1 | 12/15/2023 |  |
| 3.10 | [Articles of Amendment to Amended and Restated Articles of Incorporation](https://www.sec.gov/Archives/edgar/data/1174940/000164117225012596/ex3-1.htm) | 8-K | 001-32188 | 3.1 | 5/28/2025 |  |
| 3.11 | [Articles of Amendment to Amended and Restated Articles of Incorporation](https://www.sec.gov/Archives/edgar/data/1174940/000164117225017575/ex3-1.htm) | 8-K | 001-32188 | 3.1 | 7/2/2025 |  |
| 3.12 | [Bylaws](https://www.sec.gov/Archives/edgar/data/1174940/000100201402000328/exh3-2.htm) | SB-2 | 333-100568 | 3.2 | 10/16/02 |  |
| 3.13 | [First Amendment to Bylaws](https://www.sec.gov/Archives/edgar/data/1174940/000114420410032516/v187786_ex3-1.htm) | 8-K | 001-32188 | 3.1 | 6/9/10 |  |
| 3.14 | [Second Amendment to Bylaws](https://www.sec.gov/Archives/edgar/data/1174940/000119312510195605/dex31.htm) | 8-K | 001-32188 | 3.1 | 8/24/10 |  |
| 3.15 | [Third Amendment to Bylaws](https://www.sec.gov/Archives/edgar/data/1174940/000149315222005606/ex3-9.htm) | 8-K | 001-32188 | 3.9 | 2/28/22 |  |
| 4.1 | [Specimen Stock Certificate](https://www.sec.gov/Archives/edgar/data/1174940/000149315223002194/ex4-1.htm) | 8-K | 001-32188 | 4.1 | 1/23/23 |  |
| 4.2\* | Form of Warrant |  |  |  |  |  |
| 4.3\* | Form of Warrant Agreement |  |  |  |  |  |
| 4.4\* | Form of Unit |  |  |  |  |  |
| 4.5\* | Form of Unit Agreement |  |  |  |  |  |
| 5.1 | [Opinion of Shumaker, Loop & Kendrick, LLP](https://www.sec.gov/Archives/edgar/data/1174940/000149315226003241/ex5-1.htm) | S-3 | 333-292880 | 5.1 | 1/22/26 |  |
| 23.1 | [Consent of Cherry Bekaert LLP, an Independent Public Accounting Firm](ex23-1.htm) | S-3/A | 333-292880 |  |  | X |
| 23.2 | [Consent of Shumaker, Loop & Kendrick, LLP (included in Exhibit 5.1)](https://www.sec.gov/Archives/edgar/data/1174940/000149315226003241/ex5-1.htm) | S-3 | 333-292880 | 23.2 | 1/22/26 |  |
| 24.1 | [Powers of Attorney (included on signature page).](https://www.sec.gov/Archives/edgar/data/1174940/000149315226003241/forms-3.htm#sd_009) | S-3 | 333-292880 | 24.1 | 1/22/26 |  |
| 107 | [Filing Fee Table](https://www.sec.gov/Archives/edgar/data/1174940/000149315226003241/ex107.htm) | S-3 | 333-292880 | 107 | 1/22/26 |  |

---

\* To be filed by amendment or as an exhibit to a report pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended and incorporated herein by reference.

**SIGNATURES** 

Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and has duly caused this pre-effective amendment no. 1 to the Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Tampa, State of Florida on March 19, 2026.

---

| | |
|:---|:---|
| ORAGENICS, INC. | ORAGENICS, INC. |
| By: | */s/ Janet Huffman* |
|  | Janet Huffman |
|  | President, Chief Executive Officer (Principal Executive Officer) and Chief Financial Officer (Principal Financial Officer) |

---

Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statement has been signed below by the following persons in the capacities indicated and on March 19, 2026.

---

| | |
|:---|:---|
| **Signature** | **Title** |
| */s/ Janet Huffman* | President, Chief Executive Officer (Principal Executive Officer) and |
| Janet Huffman | Chief Financial Officer (Principal Financial Officer) |
| *\** | Chairman and Director |
| Charles L. Pope |  |
| *\** | Director |
| Robert C. Koski |  |
| *\** | Director |
| Frederick W. Telling |  |
| *\** | Director |
| Alan W. Dunton |  |
| *\** | Director |
| John Gandolfo |  |
| *\** | Director |
| Natasha Giordano |  |

---

## Exhibit 23.1

**Exhibit 23.1**

**Consent of Independent Registered Public Accounting Firm**

We consent to the incorporation by reference in this Registration Statement of Oragenics, Inc. on Form S-3 of our report, dated March 16, 2026, with respect to our audits of the consolidated financial statements of Oragenics, Inc. as of and for the years ended December 31, 2025 and 2024, which report is included in the Annual Report on Form 10-K of Oragenics, Inc. for the year ended December 31, 2025. We also consent to the reference to our firm under the heading "Experts" in the Prospectus, which is part of this Registration Statement.

*/s/ Cherry Bekaert LLP*

Tampa, Florida

March 19, 2026