# EDGAR Filing Document

**Accession Number:** 0001783328
**File Stem:** 0001193125-26-089915
**Filing Date:** 2026-3
**Character Count:** 19952
**Document Hash:** 8b8fe670ca040a9a3f45c99d1f336c3e
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-26-089915.hdr.sgml**: 20260304

**ACCESSION NUMBER**: 0001193125-26-089915

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 15

**FILED AS OF DATE**: 20260304

**DATE AS OF CHANGE**: 20260304

**EFFECTIVENESS DATE**: 20260304

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** TScan Therapeutics, Inc.
- **CENTRAL INDEX KEY:** 0001783328
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 825282075
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-293989
- **FILM NUMBER:** 26718865

**BUSINESS ADDRESS:**
- **STREET 1:** 830 WINTER STREET
- **CITY:** WALTHAM
- **STATE:** MA
- **ZIP:** 02451
- **BUSINESS PHONE:** 857-399-9500

**MAIL ADDRESS:**
- **STREET 1:** 830 WINTER STREET
- **CITY:** WALTHAM
- **STATE:** MA
- **ZIP:** 02451

**As filed with the Securities and Exchange Commission on March 4, 2026** 

**Registration No. 333-** 

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**WASHINGTON, D.C. 20549** 

**FORM S-8**

**REGISTRATION STATEMENT** 

***UNDER***

***THE SECURITIES ACT OF 1933***

## TSCAN THERAPEUTICS, INC.
**(Exact name of registrant as specified in its charter)** 

---

| | |
|:---|:---|
| **Delaware** | **82-5282075** |
| **(State or other jurisdiction of<br>incorporation or organization)** | **(I.R.S. Employer<br>Identification No.)** |
| **830 Winter Street**<br> **Waltham, Massachusetts** | **02451** |
| **(Address of Principal Executive Offices)** | **(Zip Code)** |

---

**TSCAN THERAPEUTICS, INC. AMENDED AND RESTATED 2021 EQUITY INCENTIVE PLAN** 

**TSCAN THERAPEUTICS, INC. 2021 EMPLOYEE STOCK PURCHASE PLAN** 

**(Full title of the plan)** 

**Gavin MacBeath** 

**Chief Executive Officer** 

**TScan Therapeutics, Inc.** 

**830 Winter Street** 

**Waltham, Massachusetts 02451** 

**(Name and address of agent for service)** 

**(857) 399-9500**

**(Telephone number, including area code, of agent for service)** 

***Copies to:***

**Mitchell S. Bloom, Esq.** 

**William D. Collins, Esq.** 

**Finnbarr Murphy, Esq.** 

**Goodwin Procter LLP** 

**100 Northern Avenue** 

**Boston, Massachusetts 02210** 

**(617) 570-1000**

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☐ | Accelerated filer | ☐ |
| Non-accelerated filer | ☒ | Smaller reporting company | ☒ |
|  |  | Emerging growth company | ☒ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

------

**EXPLANATORY NOTE** 

This Registration Statement on Form S-8 registers (i) 5,196,535 additional shares of common stock, $0.0001 par value per share ("Common Stock"), of TScan Therapeutics, Inc. (the "Registrant"), under the TScan Therapeutics, Inc. Amended and Restated 2021 Equity Incentive Plan (the "2021 Plan") and (ii) 569,016 additional shares of Common Stock under the TScan Therapeutics, Inc. 2021 Employee Stock Purchase Plan (the "2021 ESPP"). The number of shares of Common Stock reserved and available for issuance under the 2021 Plan is subject to an automatic annual increase on each January 1, beginning in 2022, by an amount equal to the lower of (i) four percent of the number of shares of Common Stock outstanding (including the shares of Common Stock underlying outstanding pre-funded warrants) on the immediately preceding December 31 and (ii) an amount of shares determined by our Board of Directors. Accordingly, on January 1, 2026, the number of shares of Common Stock reserved and available for issuance under the 2021 Plan increased by 5,196,535. The additional shares are of the same class as other securities relating to the 2021 Plan for which the Registrant's registration statements filed on Form S-8 with the Securities and Exchange Commission on [July 16, 2021](http://www.sec.gov/Archives/edgar/data/1783328/000119312521216925/d178021ds8.htm) (Registration No. 333-257941), [March 9, 2022](http://www.sec.gov/Archives/edgar/data/1783328/000119312522069921/d314740ds8.htm) (Registration No. 333-263380), [March 8, 2023](http://www.sec.gov/Archives/edgar/data/1783328/000119312523063834/d312398ds8.htm) (Registration No. 333-270343), [June 16, 2023](http://www.sec.gov/Archives/edgar/data/1783328/000119312523169052/d516923ds8.htm) (Registration No. 333-272733), [March 6, 2024](http://www.sec.gov/Archives/edgar/data/1783328/000119312524060705/d781311ds8.htm) (Registration No. 333-277695), [June 14, 2024](http://www.sec.gov/Archives/edgar/data/1783328/000119312524161589/d820577ds8.htm) (Registration No. 333-280212) and [March 5, 2025](http://www.sec.gov/Archives/edgar/data/1783328/000119312525047221/d824752ds8.htm) (Registration No. 333-285571) are effective. The number of shares of Common Stock reserved and available for issuance under the 2021 ESPP is subject to an automatic annual increase on each January 1, beginning in 2022, by an amount equal to the least of (i) one percent of the number of shares of Common Stock issued and outstanding on the immediately preceding December 31 or (ii) such number of shares of Common Stock as determined by our Board of Directors. Accordingly, on January 1, 2026, the number of shares of Common Stock reserved and available for issuance under the 2021 ESPP increased by 569,016. The additional shares are of the same class as other securities relating to the 2021 ESPP for which the Registrant's registration statements filed on Form S-8 with the Securities and Exchange Commission on [July 16, 2021](http://www.sec.gov/Archives/edgar/data/1783328/000119312521216925/d178021ds8.htm) (Registration No. 333-257941), [March 9, 2022](http://www.sec.gov/Archives/edgar/data/1783328/000119312522069921/d314740ds8.htm) (Registration No. 333-263380), [March 8, 2023](http://www.sec.gov/Archives/edgar/data/1783328/000119312523063834/d312398ds8.htm) (Registration No. 333-270343), [March 6, 2024](http://www.sec.gov/Archives/edgar/data/1783328/000119312524060705/d781311ds8.htm) (Registration No. 333-277695) and [March 5, 2025](http://www.sec.gov/Archives/edgar/data/1783328/000119312525047221/d824752ds8.htm) (Registration No. 333-285571) are effective. The information contained in the Registrant's registration statements on Form S-8 (Registration No. 333-257941, No. 333-263380, No. 333-270343, No. 333-272733, No. 333-277695, No. 333-280212 and No. 333-285571) is hereby incorporated by reference pursuant to General Instruction E.

------

**Part II** 

**INFORMATION REQUIRED IN THE REGISTRATION STATEMENT** 

**Item 8.** **Exhibits.** <br>

---

| | |
|:---|:---|
| **Exhibit<br>No.** | **Description** |
| 4.1 | [Amended and Restated Certificate of Incorporation of the Registrant (Incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-40603) filed with the Securities and Exchange Commission on July 20, 2021).](http://www.sec.gov/Archives/edgar/data/1783328/000119312521219696/d172723dex31.htm) |
| 4.2 | [Amended and Restated By-laws of the Registrant (Incorporated by reference to Exhibit 3.2 to the Registrant's Current Report on Form 8-K (File No. 001-40603) filed with the Securities and Exchange Commission on July 20, 2021).](http://www.sec.gov/Archives/edgar/data/1783328/000119312521219696/d172723dex32.htm) |
| 5.1\* | [Opinion of Goodwin Procter LLP.](d86992dex51.htm) |
| 23.1\* | [Consent of Deloitte & Touche LLP, independent registered public accounting firm.](d86992dex231.htm) |
| 23.2\* | [Consent of Goodwin Procter LLP (included in Exhibit 5.1).](d86992dex51.htm) |
| 24.1\* | [Power of Attorney (included on signature page).](#sig) |
| 99.1 | [TScan Therapeutics, Inc. 2021 Amended and Restated Equity Incentive Plan and form of agreements thereunder (incorporated by reference to Exhibit 10.1 to the Registrant's Current Report on Form 8-K, filed with the Securities and Exchange Commission on June 14, 2024).](http://www.sec.gov/Archives/edgar/data/1783328/000119312524161151/d785285dex101.htm) |
| 99.2 | [2021 Employee Stock Purchase Plan (Incorporated by reference to Exhibit 10.4 to the Registrant's Registration Statement on Form S-1 (File No. 333-255491) filed with the Securities and Exchange Commission on April 23, 2021).](http://www.sec.gov/Archives/edgar/data/1783328/000119312521129264/d107876dex104.htm) |
| 107.1\* | [Filing Fee Table.](d86992dexfilingfees.htm) |

---

\* Filed herewith.

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**SIGNATURES** 

Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Waltham, Commonwealth of Massachusetts, on March 4, 2026.

---

| | |
|:---|:---|
| **TScan Therapeutics, Inc.** | **TScan Therapeutics, Inc.** |
| By: | /s/ Gavin MacBeath, Ph.D. |
|  | Gavin MacBeath, Ph.D. |
|  | Chief Executive Officer<br> (Principal Executive Officer) |

---

**POWER OF ATTORNEY AND SIGNATURES** 

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Gavin MacBeath and Jason A. Amello, and each of them, as such person's true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution in each of them, for such person in such person's place and stead, in any and all capacities, to sign for us and in our names in the capacities indicated below the Registration Statement on Form S-8 of TScan Therapeutics, Inc., and any or all amendments (including post-effective amendments), and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite or necessary to be done in connection therewith and about the premises, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents or any of them, or substitutes of any of them, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement on Form S-8 has been signed by the following persons in the capacities and on the dates indicated.

---

| | | |
|:---|:---|:---|
| **Signature** | **Title** | **Date** |
| /s/ Gavin MacBeath, Ph.D.<br> Gavin MacBeath, Ph.D. | Chief Executive Officer and Director<br> (Principal Executive Officer) | March 4, 2026 |
| /s/ Jason A. Amello<br> Jason A. Amello | Chief Financial Officer<br> (Principal Financial Officer) | March 4, 2026 |
| /s/ Leiden Dworak<br> Leiden Dworak | Vice President, Finance<br> (Principal Accounting Officer) | March 4, 2026 |
| /s/ Stephen Biggar<br> Stephen Biggar, M.D., Ph.D. | Director | March 4, 2026 |
| /s/ Barbara Klencke, M.D.<br> Barbara Klencke, M.D. | Director | March 4, 2026 |
| /s/ Garry Nicholson<br> Garry Nicholson | Director | March 4, 2026 |
| /s/ Gabriela Gruia<br> Gabriela Gruia, M.D. | Director | March 4, 2026 |
| /s/ Katina Dorton<br> Katina Dorton, J.D., M.B.A. | Director | March 4, 2026 |
| /s/ R. Keith Woods<br> R. Keith Woods | Director | March 4, 2026 |

---

## Exhibit 5.1

**Exhibit 5.1** 

---

| | |
|:---|:---|
| ![LOGO](g86992g0228082626829.jpg) | Goodwin Procter LLP<br> 100 Northern Avenue<br> Boston, MA 02210<br>goodwinlaw.com<br> +1 617 570 1000 |

---

March 4, 2026

TScan Therapeutics, Inc.

830 Winter Street

Waltham, Massachusetts 02451

Re: <u>Securities Being Registered under Registration Statement on Form S-8</u>

We have acted as your counsel in connection with your filing of a Registration Statement on Form S-8 (the "Registration Statement") pursuant to the Securities Act of 1933, as amended (the "Securities Act"), on or about the date hereof relating to an aggregate of (i) 5,196,535 additional shares (the "Plan Shares") of Common Stock, $0.0001 par value per share ("Common Stock"), of TScan Therapeutics, Inc., a Delaware corporation (the "Company"), that may be issued pursuant to the Company's Amended and Restated 2021 Equity Incentive Plan (the "2021 Plan") and (ii) 569,016 additional shares (collectively with the Plan Shares, the "Shares") of Common Stock that may be issued pursuant to the Company's 2021 Employee Stock Purchase Plan (collectively with the 2021 Plan, the "Plans").

We have reviewed such documents and made such examination of law as we have deemed appropriate to give the opinion set forth below. We have relied, without independent verification, on certificates of public officials and, as to matters of fact material to the opinion set forth below, on certificates of officers of the Company.

For purposes of the opinion set forth below, we have assumed that, at the time Shares are issued, the total number of then unissued Shares, when added to the number of shares of Common Stock issued, subscribed for, or otherwise committed to be issued, does not exceed the number of shares of Common Stock authorized by the Company's certificate of incorporation.

The opinion set forth below is limited to the Delaware General Corporation Law. Based on the foregoing, we are of the opinion that the Shares have been duly authorized and, when delivered against payment therefor in accordance with the terms of the Plans, will be validly issued, fully paid and nonassessable.

This opinion letter and the opinion it contains shall be interpreted in accordance with the Core Opinion Principles as published in 74 *Business Lawyer* 815 (Summer 2019).

We hereby consent to the inclusion of this opinion as Exhibit 5.1 to the Registration Statement. In giving our consent, we do not admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations thereunder.

------

TScan Therapeutics, Inc.

March 4, 2026

---

| |
|:---|
| Very truly yours, |
| /s/ Goodwin Procter LLP |
| GOODWIN PROCTER LLP |

---

## Exhibit 23.1

**Exhibit 23.1** 

**CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM** 

We consent to the incorporation by reference in this Registration Statement on Form S-8 of our report dated March 4, 2026, relating to the financial statements of TScan Therapeutics, Inc. appearing in the Annual Report on Form 10-K of TScan Therapeutics, Inc. for the year ended December 31, 2025.

/s/ Deloitte & Touche LLP

Boston, Massachusetts

March 4, 2026

## Ex-Filing

?xml version='1.0' encoding='ASCII'? EX-FILING FEES

---

| |
|:---|
| **Calculation of Filing Fee Tables**  |
| &nbsp;&nbsp;&nbsp;&nbsp;**S-8**  |
| &nbsp;&nbsp;&nbsp;&nbsp;**TScan Therapeutics, Inc.**  |

---

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| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | **Security Type**  | **Security Class Title**  | **Fee Calculation Rule**  | **Amount Registered**  | **Proposed Maximum Offering Price Per Unit**  | **Maximum Aggregate Offering Price**  | **Fee Rate**  | **Amount of Registration Fee**  |
| 1 | Equity | Common Stock, $0.0001 par value per share | Other | 5196535 | $1.09 | $5664223.15 | 0.0001381 | $782.23 |
| 2 | Equity | Common Stock, $0.0001 par value per share | Other | 569016 | $0.92 | $523494.72 | 0.0001381 | $72.29 |
| Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: |  | $6187717.87  |  | $854.52  |
| Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  |  |  |  | $0.00  |
| Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  |  |  |  | $854.52  |

---

 **Offering Note** <br>

<sup>1</sup> Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this registration statement shall also cover any additional shares of common stock, $0.0001 par value per share (the "Common Stock"), of TScan Therapeutics, Inc. (the "Registrant") which become issuable under the TScan Therapeutics, Inc. Amended and Restated 2021 Equity Incentive Plan (the "2021 Plan") by reason of any stock dividend, stock split, recapitalization or any other similar transaction effected without the receipt of consideration which results in an increase in the number of the Registrant's outstanding shares of Common Stock. The proposed maximum offering price per share of $1.09 per share, which is the average of the high and low sale prices of the Registrant's Common Stock on the Nasdaq Global Market on February 27, 2026, is set forth solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and (h) of the Securities Act. The amount registered represents an automatic increase of 5,196,535 shares of Common Stock to the number of shares available for issuance under the 2021 Plan, effective January 1, 2026. Shares available for issuance under the 2021 Plan were previously registered on registration statements on Form S-8 filed with the Securities and Exchange Commission on July 16, 2021 (Registration No. 333-257941), March 9, 2022 (Registration No. 333-263380), March 8, 2023 (Registration No. 333-270343), June 16, 2023 (Registration No. 333-272733), March 6, 2024 (Registration No. 333-277695), June 14, 2024 (Registration No. 333-280212) and March 5, 2025 (Registration No. 333-285571).

<sup>2</sup> Pursuant to Rule 416 under the Securities Act, this registration statement shall also cover any additional shares of Common Stock of the Registrant which become issuable under the TScan Therapeutics, Inc. 2021 Employee Stock Purchase Plan (the "2021 ESPP") by reason of any stock dividend, stock split, recapitalization or any other similar transaction effected without the receipt of consideration which results in an increase in the number of the Registrant's outstanding shares of Common Stock. The proposed maximum offering price per share of $0.92 per share, which is 85% of the average of the high and low sale prices of the Registrant's Common Stock on the Nasdaq Global Market on February 27, 2026, is set forth solely for purposes of calculating the registration fee pursuant to Rules 457(c) and (h) of the Securities Act. Pursuant to the 2021 ESPP, the purchase price of the shares of Common Stock reserved for issuance thereunder will be 85% of the fair market value of a share of Common Stock on the first trading day of the offering period or on the purchase date, whichever is less. The amount registered represents an automatic increase of 569,016 shares of Common Stock to the number of shares available under the 2021 ESPP, effective January 1, 2026. Shares available for issuance under the 2021 ESPP were previously registered on registration statements on Form S-8 filed with the Securities and Exchange Commission on July 16, 2021 (Registration No. 333-257941), March 9, 2022 (Registration No. 333-263380), March 8, 2023 (Registration No. 333-270343), March 6, 2024 (Registration No. 333-277695) and March 5, 2025 (Registration No. 333-285571).

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| | |
|:---|:---|
| | |
| **Rule 457(p)** | **Rule 457(p)** |
| Fee Offset Claims | N/A |
| Fee Offset Sources | N/A |

---