# EDGAR Filing Document

**Accession Number:** 0000318154
**File Stem:** 0000318154-25-000024
**Filing Date:** 2025-6
**Character Count:** 58673
**Document Hash:** 134a5707be84e899d39e368c90f321fb
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000318154-25-000024.hdr.sgml**: 20250612

**ACCESSION NUMBER**: 0000318154-25-000024

**CONFORMED SUBMISSION TYPE**: 11-K

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20241231

**FILED AS OF DATE**: 20250612

**DATE AS OF CHANGE**: 20250612

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** AMGEN INC
- **CENTRAL INDEX KEY:** 0000318154
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 953540776
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 11-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-37702
- **FILM NUMBER:** 251043516

**BUSINESS ADDRESS:**
- **STREET 1:** ONE AMGEN CENTER DRIVE
- **CITY:** THOUSAND OAKS
- **STATE:** CA
- **ZIP:** 91320
- **BUSINESS PHONE:** (805)447-1000

**MAIL ADDRESS:**
- **STREET 1:** ONE AMGEN CENTER DRIVE
- **CITY:** THOUSAND OAKS
- **STATE:** CA
- **ZIP:** 91320

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** AMGEN
- **DATE OF NAME CHANGE:** 19870305

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington D.C. 20549**

**FORM 11-K**

**(Mark One)**

---

| | |
|:---|:---|
| 🗷 | **ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934** |

---

**For the fiscal year ended December 31, 2024** 

**OR**

---

| | |
|:---|:---|
| ◻ | **TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934** |

---

**Commission file number 001-37702**

**RETIREMENT AND SAVINGS PLAN FOR**

**AMGEN MANUFACTURING LIMITED LLC**

State Road 31, Kilometer 24.6, Juncos, Puerto Rico 00777

(Full title and address of the plan)

**AMGEN INC.**

(Name of issuer of the securities held)

---

| | |
|:---|:---|
| **One Amgen Center Drive,** | **91320-1799** |
| **Thousand Oaks, California** | (Zip Code) |
| (Address of principal executive offices) | |

---

------

**Retirement and Savings Plan for**

**Amgen Manufacturing Limited LLC**

**Audited Financial Statements**

**and Supplemental Schedule**

**Year Ended December 31, 2024**

**Contents**

---

| | |
|:---|:---|
| <u>[Report of Independent Registered Public Accounting Firm](#i73b0e0d455b841edb1db2b09812a866f_7)</u> | <u>[1](#i73b0e0d455b841edb1db2b09812a866f_7)</u> |
| **Audited Financial Statements:** |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[Statements of Net Assets Available for Benefits at December 31, 2024 and 2023](#i73b0e0d455b841edb1db2b09812a866f_10)</u> | <u>[2](#i73b0e0d455b841edb1db2b09812a866f_10)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[Statement of Changes in Net Assets Available for Benefits for the year ended December 31, 2024](#i73b0e0d455b841edb1db2b09812a866f_13)</u> | <u>[3](#i73b0e0d455b841edb1db2b09812a866f_13)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[Notes to Financial Statements](#i73b0e0d455b841edb1db2b09812a866f_16)</u> | <u>[4](#i73b0e0d455b841edb1db2b09812a866f_16)</u> |
| **Supplemental Schedule:** |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[Schedule of Assets (Held at End of Year)](#i73b0e0d455b841edb1db2b09812a866f_34)</u> | <u>[10](#i73b0e0d455b841edb1db2b09812a866f_34)</u> |
| <u>[Index to Exhibit](#i73b0e0d455b841edb1db2b09812a866f_37)</u> | <u>[18](#i73b0e0d455b841edb1db2b09812a866f_37)</u> |
| <u>[Signatures](#i73b0e0d455b841edb1db2b09812a866f_40)</u> | <u>[19](#i73b0e0d455b841edb1db2b09812a866f_40)</u> |

---

------

**Report of Independent Registered Public Accounting Firm**

To the Plan Participants and the Plan Administrator of the Retirement and Savings Plan for Amgen Manufacturing Limited LLC

**Opinion on the Financial Statements**

We have audited the accompanying statements of net assets available for benefits of the Retirement and Savings Plan for Amgen Manufacturing Limited LLC (the Plan) as of December 31, 2024 and 2023, and the related statement of changes in net assets available for benefits for the year ended December 31, 2024, and the related notes (collectively referred to as the "financial statements"). In our opinion, the financial statements present fairly, in all material respects, the net assets available for benefits of the Plan at December 31, 2024 and 2023, and the changes in its net assets available for benefits for the year ended December 31, 2024, in conformity with U.S. generally accepted accounting principles.

**Basis for Opinion**

These financial statements are the responsibility of the Plan's management. Our responsibility is to express an opinion on the Plan's financial statements based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (PCAOB) and are required to be independent with respect to the Plan in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement, whether due to error or fraud. The Plan is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Plan's internal control over financial reporting. Accordingly, we express no such opinion.

Our audits included performing procedures to assess the risks of material misstatement of the financial statements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements. We believe that our audits provide a reasonable basis for our opinion.

**Supplemental Schedule Required by ERISA**

The accompanying supplemental schedule of assets (held at end of year) as of December 31, 2024, (referred to as the "supplemental schedule"), has been subjected to audit procedures performed in conjunction with the audit of the Plan's financial statements. The information in the supplemental schedule is the responsibility of the Plan's management. Our audit procedures included determining whether the information reconciles to the financial statements or the underlying accounting and other records, as applicable, and performing procedures to test the completeness and accuracy of the information presented in the supplemental schedule. In forming our opinion on the information, we evaluated whether such information, including its form and content, is presented in conformity with the Department of Labor's Rules and Regulations for Reporting and Disclosure under the Employee Retirement Income Security Act of 1974. In our opinion, the information is fairly stated, in all material respects, in relation to the financial statements as a whole.

/s/ ERNST & YOUNG LLP

We have served as the Plan's auditor since 1992.

Los Angeles, California

June 12, 2025

------

**Retirement and Savings Plan for Amgen Manufacturing Limited LLC**

**Statements of Net Assets Available for Benefits**

---

| | | |
|:---|:---|:---|
| | **December 31,** | **December 31,** |
| | **2024** | **2023** |
| **Assets** |  |  |
| &nbsp;&nbsp;&nbsp;Investments at fair value | $762010202 | $702634440 |
| &nbsp;&nbsp;&nbsp;Notes receivable from participants | 18107898 | 16846516 |
| &nbsp;&nbsp;&nbsp;Other – principally due from broker | 302276 | 713083 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total assets | 780420376 | 720194039 |
| **Liabilities** |  |  |
| &nbsp;&nbsp;&nbsp;Other – principally due to broker | 332225 | 634863 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total liabilities | 332225 | 634863 |
| **Net assets available for benefits** | $780088151 | $719559176 |

---

*See accompanying notes.*

------

**Retirement and Savings Plan for Amgen Manufacturing Limited LLC**

**Statement of Changes in Net Assets Available for Benefits**

---

| | |
|:---|:---|
| | **Year Ended December 31,**<br>**2024** |
| Additions to (deductions from) net assets: |  |
| &nbsp;&nbsp;&nbsp;Employer contributions | $21287553 |
| &nbsp;&nbsp;&nbsp;Participant contributions | 19232551 |
| &nbsp;&nbsp;&nbsp;Rollover contributions | 288090 |
| &nbsp;&nbsp;&nbsp;Interest and dividend income | 5416829 |
| &nbsp;&nbsp;&nbsp;Net realized/unrealized gains | 46915641 |
| &nbsp;&nbsp;&nbsp;Interest income on notes receivable from participants | 1174893 |
| &nbsp;&nbsp;&nbsp;Benefits paid | (33154339) |
| &nbsp;&nbsp;&nbsp;Investment and administrative fees | (632243) |
| Net increase | 60528975 |
| Net assets available for benefits at beginning of year | 719559176 |
| Net assets available for benefits at end of year | $780088151 |

---

*See accompanying notes.*

------

**Retirement and Savings Plan for Amgen Manufacturing Limited LLC**

**Notes to Financial Statements**

**December 31, 2024** 

**1. Description of the Plan**

The following is a description of the Retirement and Savings Plan for Amgen Manufacturing Limited LLC (the Plan). Effective May 1, 2024, the Plan (formerly known as the Retirement and Savings Plan for Amgen Manufacturing, Limited) was amended solely to reflect that, as a result of an internal organizational restructuring that had no substantive impact on participants or Plan assets, the Plan sponsor is now Amgen Manufacturing Limited LLC (the successor entity to Amgen Manufacturing, Limited). The description below provides only general information, and accordingly, participants should refer to the Plan document for a more complete description of the Plan's provisions.

*General*

The Plan was established effective May 1, 1992, and was amended and restated effective January 1, 2017, and subsequently amended, with the most recent amendment adopted on June 7, 2024. The Plan is a defined contribution plan covering substantially all Puerto Rico resident employees of Amgen Manufacturing Limited LLC (the Company), a wholly owned subsidiary of Amgen Inc. (Amgen). The Plan is intended to qualify under Section 1081.01 of the Puerto Rico Internal Revenue Code of 2011, as amended (the PR Code) (see Note 4, *Income Tax Status*) and section 407(d)(3)(A) of the Employee Retirement Income Security Act of 1974 (ERISA).

*Contributions*

Subject to certain limitations (as defined in the Plan), participants may elect to contribute up to 30% of their eligible compensation in pre-tax contributions and after-tax contributions or a combination of these types of contributions (together, Individual Contributions). A participant's pre-tax contributions are subject to the PR Code and Plan limitations and could not exceed $15,000 in 2024. Participants may elect to contribute after-tax contributions beginning January 1 of the year following the year the participant was hired. Participant after-tax contributions are subject to the PR Code and Plan limitations and could not exceed $1,500 in 2024. Unless an employee has voluntarily enrolled in the Plan or has declined to participate in the Plan within the first 30 days of employment, all newly eligible participants are automatically enrolled in the Plan, and contributions equal to 5% of their eligible compensation are withheld and contributed to the Plan as pre-tax contributions; such contributions are automatically increased by 1% per year until their contributions reach 10% of their eligible compensation. Participants may elect to adjust, cease or resume their Individual Contributions at any time.

Participants who are at least age 50 by the close of the Plan year may also elect to make certain additional pre-tax Individual Contributions, referred to as catch-up contributions, that are subject to the PR Code and Plan limitations and could not exceed $1,500 in 2024. Participants may also contribute pre-tax and after-tax amounts representing distributions from certain other retirement plans qualified in Puerto Rico, referred to as rollover contributions (as defined in the Plan).

Each pay period, the Company makes a non-elective contribution for all eligible participants, whether or not they have elected to make Individual Contributions to the Plan, equal to 4% of each participant's eligible compensation up to a maximum of $13,800 in 2024 (Core Contributions). In addition, the Company makes a contribution equal to amounts contributed by the participant as pre-tax contributions, including catch-up contributions, of up to 5% of eligible compensation (Matching Contributions). Matching Contributions could not exceed $15,000 in 2024 (or $16,500 for catch-up eligible participants).

Participants select the investments in which their Individual Contributions, including their Core Contributions and Matching Contributions (collectively, Company Contributions), are to be invested, electing among various alternatives, including Amgen common stock (Amgen stock). Participants may direct a maximum of 20% of contributions to be invested in Amgen stock. In addition, participants may transfer amounts among the investment options at any time, subject to certain limitations. Notwithstanding the foregoing, if 20% or more of the value of a participant's Plan account is invested in Amgen stock, the Plan document provides that no transfers from other investment options can be made to invest in Amgen stock.

The accounts of participants who have not made an investment election are allocated to investments under a qualified default investment alternative, which is intended to be compliant with ERISA regulations. At any time, participants may elect to alter the investments in their accounts made under a qualified default investment alternative.

*Vesting*

Participants are immediately vested with respect to their Individual Contributions and Matching Contributions and earnings and losses (hereafter referred to as earnings) thereon. Participants hired prior to January 1, 2020, are also immediately vested

------

**Retirement and Savings Plan for Amgen Manufacturing Limited LLC**

**Notes to Financial Statements (continued)**

with respect to their Core Contributions and earnings thereon. Participants hired on or after January 1, 2020, vest in full with respect to their Core Contributions and earnings thereon after three years of service, as defined by the terms of the Plan, or upon reaching age 65 while employed by the Company, if earlier. If a participant ceases to be an employee before fully vesting in their account, the non-vested Core Contributions and earnings thereon of the participant's account will be treated as a forfeiture, as defined by the terms of the Plan, on the earlier of (a) the date the participant incurs a five-year break in service, as defined by the terms of the Plan or, (b) the date the participant receives a distribution of the entire vested portion of their account.

*Participant Accounts*

Each participant's account is credited with: (a) the participant's Individual Contributions; (b) an allocation of Company Contributions; and (c) earnings. The benefit to which a participant is entitled is the benefit that can be provided from the participant's account.

*Plan Investments*

Plan participants can invest in seven different asset classes as well as Amgen stock or can actively manage their account under a self-directed brokerage arrangement in which a wider array of investment options are available. The value of an investment in an asset class is determined by its underlying investment vehicles, which may include one or more of the following: mutual funds, collective trust funds and portfolios, which are separately managed exclusively for the benefit of Plan participants and their beneficiaries (separately managed portfolios). The separately managed portfolios are composed primarily of investments in publicly traded common and preferred stocks. The asset classes are designed to provide participants with choices among a variety of investment objectives.

*Payments of Benefits*

Subject to Plan limitations, upon termination of employment, including termination due to disability (as defined in the Plan) or retirement, a participant may elect to receive a full or partial distribution of his or her account balance in: (a) a single payment in cash; (b) a single distribution in full shares of Amgen stock (with any fractional shares paid in cash); (c) a single distribution paid in a combination of cash and full shares of Amgen stock; or (d) a rollover distribution to an eligible retirement plan.

Participants may also elect to maintain their account balance in the Plan subsequent to termination of employment, provided that their account balance is greater than $1,000.

If a participant dies before receiving the value of his or her account balance, the participant's beneficiary may elect to receive the distribution of remaining funds from among the alternatives described above, subject to certain Plan limitations.

No withdrawals may be made from the Plan while a participant continues to be employed by the Company except in certain circumstances including, but not limited to, financial hardship, disability and attainment of age 59 1/2.

*Notes Receivable from Participants*

Subject to certain restrictions, a participant can have up to two loans outstanding at any one time from his or her Plan account with a combined maximum loan amount that may not exceed the lesser of: (a) 50% of the participant's account balance or (b) $50,000 less certain adjustments, as applicable (as defined in the Plan). A participant's loan is secured by his or her Plan account balance. Loans bear interest at fixed rates which, until changed by the Company, are based on the prime rate plus one percentage point as published in The Wall Street Journal, determined as of the last day of the calendar quarter preceding origination or such other rate as may be required by law. Loans are generally payable in installments over periods ranging from one to five years, unless the loan is used to acquire a principal residence for which the term of the loan may be up to 20 years. Principal and interest payments are allocated to the participant's account.

*Plan Termination*

Although it has not expressed any intent to do so, the Company has the right under the Plan to terminate the Plan subject to the provisions of ERISA. Upon termination, participants would become fully vested in Core Contributions and receive distributions of their account balances.

------

**Retirement and Savings Plan for Amgen Manufacturing Limited LLC**

**Notes to Financial Statements (continued)**

*Trustee and Custodians*

Banco Popular de Puerto Rico is the Plan's trustee. Bank of America, N.A. is the Plan's custodian with respect to the self-directed brokerage arrangement and the Amgen common stock fund. Northern Trust Company, NA (Northern) is the Plan's custodian with respect to the asset classes.

**2. Summary of Significant Accounting Policies**

*Basis of Accounting*

The accompanying financial statements are prepared on the accrual basis of accounting. Benefits to participants are recorded when paid.

*Fair Value Measurement*

The investments of the Plan are reported at fair value. Fair value is generally defined as the price that would be received to sell an asset or paid to transfer a liability (the exit price) in an orderly transaction between market participants at the measurement date (see Note 3, *Fair Value Measurements*).

*Investment Income and Losses*

Dividend income is recognized on the ex-dividend date, and interest income is recorded on an accrual basis. Unrealized gains and losses on investments are measured by the change in the difference between the fair value and cost of the securities held at the beginning of the year (or date purchased if acquired during the Plan year) and the end of the year. Realized gains and losses from security transactions are recorded based on the weighted-average cost of securities sold.

*Notes Receivable from Participants*

Notes receivable from participants are carried at their unpaid balance plus accrued but unpaid interest, as applicable.

*Due from/to Brokers*

Purchases and sales of investments are recorded on a trade-date basis. Amounts due from and due to brokers arise from unsettled sale and purchase transactions, respectively.

*Use of Estimates*

The preparation of financial statements in conformity with U.S. generally accepted accounting principles (GAAP) requires management to make estimates and assumptions that affect the amounts reported in the financial statements, accompanying notes and supplemental schedule. Actual results could differ from those estimates.

*Risks and Uncertainties*

The Plan provides for investment options representing varied combinations of equities (including Amgen stock), fixed income, and other investments. Investments, in general, particularly in securities, are exposed to various risks, such as interest rate, inflation, market and credit risks, among others. Market risk includes global events which could impact the value of investments, including securities, such as a pandemic or international conflict. Due to the level of risk associated with certain investments, including securities, it is at least reasonably possible that changes in the values of the Plan's investments, including securities, will occur in the near term and that such changes could materially affect participant account balances and the amounts reported in the Plan's financial statements.

**3. Fair Value Measurements**

The Plan uses various valuation approaches in determining the fair value of investments within a hierarchy that maximizes the use of observable inputs and minimizes the use of unobservable inputs by requiring that observable inputs be used when available. Observable inputs are inputs that market participants would use in pricing the investment based on market data obtained from independent sources. Unobservable inputs are inputs that reflect assumptions about the inputs that market participants would use in pricing the investment and are developed based on the best information available in the circumstances.

------

**Retirement and Savings Plan for Amgen Manufacturing Limited LLC**

**Notes to Financial Statements (continued)**

The fair value hierarchy is divided into three levels based on the source of inputs as follows:

Level 1 – Valuations based on unadjusted quoted prices in active markets for identical investments that the Plan has the ability to access

Level 2 – Valuations for which all significant inputs are observable, either directly or indirectly, other than Level 1 inputs

Level 3 – Valuations based on inputs that are unobservable and significant to the overall fair value measurement

The availability of observable inputs can vary among the various types of investments. To the extent that the valuation is based on models or inputs that are less observable or unobservable in the market, the determination of fair value requires more judgment. In certain cases, the inputs used for measuring fair value may fall into different levels of the fair value hierarchy. In such cases, for financial statement disclosure purposes, the level in the fair value hierarchy within which the fair value measurement is categorized is based on the lowest level of input used that is significant to the overall fair value measurement.

The following fair value hierarchy tables present information about each major class/category of the Plan's investments measured at fair value:

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Fair value measurements at December 31, 2024, using** | **Fair value measurements at December 31, 2024, using** | **Fair value measurements at December 31, 2024, using** | **Fair value measurements at December 31, 2024, using** |
| | **Quoted prices<br>in active<br>markets for<br>identical<br>assets<br>(Level 1)** | **Significant<br>other<br>observable<br>inputs<br>(Level 2)** | **Significant<br>unobservable<br>inputs<br>(Level 3)** | **Total** |
| Amgen stock | $100973506 | $— | $— | $100973506 |
| Cash and cash equivalents | 43702 |  |  | 43702 |
| Collective trust funds |  | 577297941 |  | 577297941 |
| Common and preferred stock | 47870415 |  |  | 47870415 |
| Mutual funds | 16198902 |  |  | 16198902 |
| Self-directed brokerage accounts | 19625736 |  |  | 19625736 |
| Total investments at fair value | $184712261 | $577297941 | $— | $762010202 |

---

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Fair value measurements at December 31, 2023, using** | **Fair value measurements at December 31, 2023, using** | **Fair value measurements at December 31, 2023, using** | **Fair value measurements at December 31, 2023, using** |
| | **Quoted prices<br>in active<br>markets for<br>identical<br>assets<br>(Level 1)** | **Significant<br>other<br>observable<br>inputs<br>(Level 2)** | **Significant<br>unobservable<br>inputs<br>(Level 3)** | **Total** |
| Amgen stock | $113016422 | $— | $— | $113016422 |
| Cash and cash equivalents | 30340 |  |  | 30340 |
| Collective trust funds |  | 492330408 |  | 492330408 |
| Common and preferred stocks | 73030315 |  |  | 73030315 |
| Mutual funds | 10787733 |  |  | 10787733 |
| Self-directed brokerage accounts | 13439222 |  |  | 13439222 |
| Total investments at fair value | $210304032 | $492330408 | $— | $702634440 |

---

The fair values of substantially all common stocks (including Amgen stock), preferred stocks, mutual funds and underlying investments of self-directed brokerage accounts are valued using quoted market prices in active markets with no valuation adjustment.

------

**Retirement and Savings Plan for Amgen Manufacturing Limited LLC**

**Notes to Financial Statements (continued)**

Collective trust funds represent interests in pooled investment vehicles designed typically for collective investment of employee benefit trusts. The fair values of these investments are determined by reference to the net asset value per unit provided by the fund managers as the basis for current transactions.

**4. Income Tax Status**

The Plan received an opinion letter from the Puerto Rico Treasury Department (PRTD) dated February 26, 2018, with an effective date of January 1, 2017, stating that the Plan meets the requirements of Section 1081.01 of the PR Code and the regulations thereunder, and, therefore the related trust forming part of the Plan is exempt from taxation. Subsequently, seven amendments were made to the Plan, and the Plan received letters from the PRTD stating the PRTD has no objection to the first five of these amendments. The Company has submitted the sixth and seventh amendments to the PRTD requesting an opinion that the Plan remains in compliance with the PR Code and regulations thereunder. Once qualified, the Plan is required to operate in conformity with the PR Code to maintain its qualification.

For taxable year 2024, the Company believes the Plan satisfied, and operated in compliance with, the applicable requirements of the PR Code and therefore believes that the Plan, as amended, is qualified and the related trust is tax exempt. The Company has indicated that it currently intends to continue to take the necessary steps, if any, to maintain the Plan's compliance with the applicable requirements of the PR Code.

**5. Party-in-Interest Transactions**

Parties-in-interest are certain entities defined under Department of Labor regulations, including Amgen, and other parties that provide services to the Plan, such as the trustees, custodians and investment managers. The Plan pays the custodians certain administrative and investment management fees, and the Company pays certain administrative fees on behalf of the Plan. The Plan invests in collective trust funds managed by Northern, certain of the Plan's investment managers and other third parties and may invest in securities of entities that are parties-in-interest. The Plan also invests in shares of common stock of Amgen and receives dividends on those shares. Notes receivable from participants are also considered party-in-interest transactions.

------

**Retirement and Savings Plan for Amgen Manufacturing Limited LLC**

**Notes to Financial Statements (continued)**

**6. Reconciliation of Financial Statements to the Form 5500**

The reconciliation of net assets available for benefits per the financial statements to the Form 5500 consisted of the following:

---

| | | |
|:---|:---|:---|
| | **December 31,** | **December 31,** |
| | **2024** | **2023** |
| Net assets available for benefits per the financial statements | $780088151 | $719559176 |
| Amounts allocated to withdrawing participants | (9000) | (27778) |
| Deemed loans | (887701) | (850054) |
| &nbsp;&nbsp;&nbsp;Net assets per the Form 5500 | $779191450 | $718681344 |

---

The following is a reconciliation of expenses per the financial statements to the Form 5500:

---

| | |
|:---|:---|
| | **Year Ended December 31, 2024** |
| Benefits paid | $(33154339) |
| Investment and administrative fees | (632243) |
| &nbsp;&nbsp;&nbsp;Total expenses per the financial statements | (33786582) |
| Amounts allocated to withdrawing participants at December 31, 2023 | 27778 |
| Amounts allocated to withdrawing participants at December 31, 2024 | (9000) |
| Deemed loans at December 31, 2023 | 850054 |
| Deemed loans at December 31, 2024 | (887701) |
| &nbsp;&nbsp;&nbsp;Total expenses per the Form 5500 | $(33805451) |

---

------

**Supplemental Schedule**

**Retirement and Savings Plan for Amgen Manufacturing Limited LLC**

**EIN: 98-0210484 Plan: #001**

**As of December 31, 2024** 

**Schedule H, line 4i – Schedule of Assets (Held at End of Year)**

---

| | | | |
|:---|:---|:---|:---|
| **Identity of Issue** | **Description of Investment** | **Current Value** | **Current Value** |
| Amgen stock\* | Employer Securities 387,406 shares | $100973506 |  |
|  |  |  | $100973506 |
| Capital Preservation Asset Class: |  |  |  |
| Wells Fargo Stable Value Fund W\* | Collective Trust Fund 1,402,332 units | 90775341 |  |
| NT Collective Short Term Investment Fund\* | Collective Trust Fund 4,784,875 units | 4784875 |  |
| Total Capital Preservation Asset Class |  |  | 95560216 |
| Fixed Income Active Asset Class: |  |  |  |
| MetLife Core Plus Collective Fund\* | Collective Trust Fund 780,607 units | 7868517 |  |
| Wellington Core Bond Plus Portfolio Collective Investment Trust II\* | Collective Trust Fund 704,441 units | 7826344 |  |
| Northern Trust Global Investments Collective Daily Aggregate Bond Index Fund - Non Lending\* | Collective Trust Fund 21,744 units | 3266157 |  |
| Schroder Global Strategic Bond Trust Class W\* | Collective Trust Fund 221,861 units | 2442691 |  |
| NT Collective Short Term Investment Fund\* | Collective Trust Fund 4 units | 4 |  |
| Total Fixed Income Active Asset Class |  |  | 21403713 |
| Fixed Income Index Asset Class: |  |  |  |
| Northern Trust Global Investments Collective Daily Aggregate Bond Index Fund - Non Lending\* | Collective Trust Fund 940,926 units | 141336449 |  |
| NT Collective Short Term Investment Fund\* | Collective Trust Fund 14 units | 14 |  |
| Total Fixed Income Index Asset Class |  |  | 141336463 |
| U.S. Equity Active Asset Class: |  |  |  |
| Northern Trust Collective Russell 1000 Value Index Fund - Non Lending\* | Collective Trust Fund 16,013 units | 10215354 |  |
| NT Collective Russell 3000 Index Fund / Non Lending\* | Collective Trust Fund 49,090 units | 4557669 |  |
| Amazon Inc. | Common and Preferred Stock 6,795 shares | 1490755 |  |
| Nvidia Corporation | Common and Preferred Stock 10159 shares | 1364252 |  |
| Microsoft Corporation | Common and Preferred Stock 3,135 shares | 1321403 |  |
| NT Collective Short Term Investment Fund\* | Collective Trust Fund 971,898 units | 971898 |  |
| Facebook Inc. Class A | Common and Preferred Stock 1,480 shares | 866555 |  |
| ServiceNow, Inc. | Common and Preferred Stock 683 shares | 724062 |  |
| Apple Inc. | Common and Preferred Stock 2,812 shares | 704181 |  |
| Visa Inc. Class A | Common and Preferred Stock 2,214 shares | 699713 |  |
| SS&C Technologies Holdings Inc. | Common and Preferred Stock 7,055 shares | 534628 |  |
| Netflix, Inc. | Common and Preferred Stock 540 shares | 481313 |  |
| Entegris Inc. | Common and Preferred Stock 4,522 shares | 447949 |  |
| CVS Health Corporation | Common and Preferred Stock 9,920 shares | 445309 |  |
| UnitedHealth Group Incorporated | Common and Preferred Stock 874 shares | 442122 |  |
| Baxter International Inc. | Common and Preferred Stock 15,095 shares | 440170 |  |
| Atlassian Corporation Class A | Common and Preferred Stock 1,771 shares | 431026 |  |

---

------

Schedule H, line 4i – Schedule of Assets (Held at End of Year) (continued)

---

| | | |
|:---|:---|:---|
| **Identity of Issue** | **Description of Investment** | **Current Value** |
| S&P Global Inc. | Common and Preferred Stock 837 shares | 416851 |
| Shopify Inc. Class A | Common and Preferred Stock 3,904 shares | 415112 |
| Intuit Inc. | Common and Preferred Stock 645 shares | 405383 |
| Aon plc | Common and Preferred Stock 1,120 shares | 402259 |
| Citigroup Inc. | Common and Preferred Stock 5,546 shares | 390383 |
| Waste Management, Inc. | Common and Preferred Stock 1,932 shares | 389858 |
| Gartner Inc. | Common and Preferred Stock 786 shares | 380793 |
| Thermo Fisher Scientific Inc. | Common and Preferred Stock 729 shares | 379248 |
| Canadian Pacific Kansas City Limited | Common and Preferred Stock 5,114 shares | 370100 |
| Danaher Corporation | Common and Preferred Stock 1,592 shares | 365444 |
| Novo Nordisk A/S | Common and Preferred Stock 4,195 shares | 360854 |
| STERIS plc | Common and Preferred Stock 1,754 shares | 360552 |
| Halozyme Therapeutics Inc. | Common and Preferred Stock 7,447 shares | 356041 |
| Yum! Brands, Inc. | Common and Preferred Stock 2,651 shares | 355658 |
| Dow Inc. | Common and Preferred Stock 8,744 shares | 350897 |
| Clean Harbors Inc. | Common and Preferred Stock 1,513 shares | 348202 |
| Wells Fargo & Company\* | Common and Preferred Stock 4,922 shares | 345721 |
| Datadog, Inc. Class A | Common and Preferred Stock 2,334 shares | 333505 |
| Humana Inc. | Common and Preferred Stock 1,308 shares | 331853 |
| Synopsys Inc. | Common and Preferred Stock 675 shares | 327618 |
| Global Payments Inc. | Common and Preferred Stock 2,882 shares | 322957 |
| Capital One Financial Corporation | Common and Preferred Stock 1,809 shares | 322581 |
| Fresenius Medical Care | Common and Preferred Stock 14,095 shares | 319111 |
| RB Global Inc. | Common and Preferred Stock 3,501 shares | 315825 |
| Amphenol Corporation Class A | Common and Preferred Stock 4,544 shares | 315581 |
| Ecolab Inc. | Common and Preferred Stock 1,344 shares | 314926 |
| Workday, Inc. | Common and Preferred Stock 1,216 shares | 313764 |
| Waste Connections Inc. | Common and Preferred Stock 1,808 shares | 310217 |
| Dollar General Corporation | Common and Preferred Stock 4,032 shares | 305706 |
| Merit Medical Systems Inc. | Common and Preferred Stock 3,155 shares | 305152 |
| MSCI Inc. | Common and Preferred Stock 508 shares | 304805 |
| Magna International Inc. | Common and Preferred Stock 7,264 shares | 303563 |
| DexCom, Inc. | Common and Preferred Stock 3,840 shares | 298637 |
| Spotify Technology S.A. | Common and Preferred Stock 665 shares | 297508 |
| Euronet Worldwide Inc. | Common and Preferred Stock 2,864 shares | 294534 |
| Sea Limited | Common and Preferred Stock 2,651 shares | 281271 |
| Churchill Downs Inc. | Common and Preferred Stock 2,062 shares | 275359 |
| Samsara Inc. Class A | Common and Preferred Stock 6,253 shares | 273194 |
| Lear Corporation | Common and Preferred Stock 2,845 shares | 269422 |
| Trimble Inc. | Common and Preferred Stock 3,809 shares | 269144 |
| CarGurus Inc. Class A | Common and Preferred Stock 7,354 shares | 268715 |
| Cognizant Technology Solutions Corporation Class A | Common and Preferred Stock 3,480 shares | 267612 |
| Block, Inc. | Common and Preferred Stock 3,145 shares | 267294 |
| Ametek Inc. | Common and Preferred Stock 1,453 shares | 261918 |
| MetLife Inc.\* | Common and Preferred Stock 3,189 shares | 261115 |
| Equitable Holdings Inc. | Common and Preferred Stock 5,526 shares | 260661 |
| Bank of America Corporation\* | Common and Preferred Stock 5,916 shares | 260008 |
| Charter Communications Inc. | Common and Preferred Stock 752 shares | 257763 |
| Cloudflare, Inc. | Common and Preferred Stock 2,385 shares | 256817 |
| American Express Company | Common and Preferred Stock 853 shares | 253162 |
| Autodesk, Inc. | Common and Preferred Stock 854 shares | 252417 |

---

------

Schedule H, line 4i – Schedule of Assets (Held at End of Year) (continued)

---

| | | |
|:---|:---|:---|
| **Identity of Issue** | **Description of Investment** | **Current Value** |
| Alphabet Inc. | Common and Preferred Stock 1,314 shares | 250238 |
| Bio-Techne Corporation | Common and Preferred Stock 3,401 shares | 244974 |
| Intercontinental Exchange, Inc. | Common and Preferred Stock 1,623 shares | 241843 |
| BWX Technologies Inc. | Common and Preferred Stock 2,167 shares | 241382 |
| Bristol Myers Squibb | Common and Preferred Stock 4,248 shares | 240267 |
| HealthEquity Inc. | Common and Preferred Stock 2,496 shares | 239491 |
| Alight Inc. Class A | Common and Preferred Stock 33,459 shares | 231536 |
| Amdocs Limited | Common and Preferred Stock 2,652 shares | 225791 |
| Skyworks Solutions Inc | Common and Preferred Stock 2,524 shares | 223828 |
| Brown & Brown Inc. | Common and Preferred Stock 2,191 shares | 223526 |
| ASML Holding N.V. | Common and Preferred Stock 319 shares | 221093 |
| Voya Financial Inc. | Common and Preferred Stock 3,208 shares | 220807 |
| Okta Inc. | Common and Preferred Stock 2,790 shares | 219852 |
| Medtronic PLC | Common and Preferred Stock 2,734 shares | 218392 |
| Pfizer Inc. | Common and Preferred Stock 8,218 shares | 218024 |
| Tyson Foods Inc. | Common and Preferred Stock 3,766 shares | 216319 |
| Delta Air Lines, Inc. | Common and Preferred Stock 3,568 shares | 215864 |
| Nu Holdings Limited | Common and Preferred Stock 20,612 shares | 213540 |
| Ingredion Inc. | Common and Preferred Stock 1,528 shares | 210192 |
| Shell plc | Common and Preferred Stock 3,331 shares | 208687 |
| DoorDash, Inc. Class A | Common and Preferred Stock 1,230 shares | 206333 |
| Salesforce.com Inc. | Common and Preferred Stock 613 shares | 204944 |
| LKQ Corporation | Common and Preferred Stock 5,393 shares | 198193 |
| Huntington Bancshares Inc. | Common and Preferred Stock 12,066 shares | 196314 |
| Starbucks Corporation | Common and Preferred Stock 2,148 shares | 196005 |
| Applovin Corporation Class A | Common and Preferred Stock 599 shares | 193974 |
| IDEX Corporation | Common and Preferred Stock 918 shares | 192128 |
| Charles River Laboratories International Inc. | Common and Preferred Stock 1,020 shares | 188292 |
| Generac Holdings Inc. | Common and Preferred Stock 1,172 shares | 181719 |
| Sensata Technologies BV Holding | Common and Preferred Stock 6,557 shares | 179662 |
| Newell Brands Inc. | Common and Preferred Stock 17,875 shares | 178035 |
| Viper Energy Inc. | Common and Preferred Stock 3,625 shares | 177879 |
| Waystar Holding Corporation | Common and Preferred Stock 4,805 shares | 176344 |
| TE Connectivity plc | Common and Preferred Stock 1,206 shares | 172422 |
| PVH Corporation | Common and Preferred Stock 1,629 shares | 172267 |
| Dynatrace Inc. | Common and Preferred Stock 3,168 shares | 172181 |
| Uber Technologies, Inc. | Common and Preferred Stock 2,818 shares | 169982 |
| Doximity Inc. | Common and Preferred Stock 3,172 shares | 169353 |
| NOV Inc. | Common and Preferred Stock 11,274 shares | 164600 |
| UGI Corporation | Common and Preferred Stock 5,819 shares | 164270 |
| Henry Schein Inc. | Common and Preferred Stock 2,340 shares | 161928 |
| Veracyte Inc. | Common and Preferred Stock 4,027 shares | 159469 |
| Coherent Corporation | Common and Preferred Stock 1,681 shares | 159241 |
| Heico Corporation Class A | Common and Preferred Stock 687 shares | 158726 |
| The Cooper Companies, Inc. | Common and Preferred Stock 1,723 shares | 158395 |
| Chewy Inc. Class A | Common and Preferred Stock 4,701 shares | 157436 |
| Remitly Global Inc. | Common and Preferred Stock 6,933 shares | 156478 |
| First American Financial Corporation | Common and Preferred Stock 2,497 shares | 155913 |
| MACOM Technology Solutions Holdings Inc. | Common and Preferred Stock 1,193 shares | 154983 |
| Roblox Corporation Class A | Common and Preferred Stock 2,605 shares | 150725 |
| Huron Consulting Group Inc. | Common and Preferred Stock 1,156 shares | 143645 |

---

------

Schedule H, line 4i – Schedule of Assets (Held at End of Year) (continued)

---

| | | |
|:---|:---|:---|
| **Identity of Issue** | **Description of Investment** | **Current Value** |
| GlobalFoundries Inc. | Common and Preferred Stock 3,331 shares | 142933 |
| AerCap Holdings N.V. | Common and Preferred Stock 1,488 shares | 142402 |
| Blackbaud, Inc. | Common and Preferred Stock 1,921 shares | 142000 |
| Dolby Laboratories Inc. | Common and Preferred Stock 1,811 shares | 141439 |
| Cabot Corporation | Common and Preferred Stock 1,526 shares | 139339 |
| Axon Enterprise, Inc. | Common and Preferred Stock 234 shares | 139071 |
| Tandem Diabetes Care Inc. | Common and Preferred Stock 3,825 shares | 137777 |
| Woodward Inc. | Common and Preferred Stock 796 shares | 132470 |
| Snowflake Inc. Class A | Common and Preferred Stock 857 shares | 132329 |
| ACV Auctions Inc. Class A | Common and Preferred Stock 6,060 shares | 130896 |
| UBS Group AG | Common and Preferred Stock 4,273 shares | 129557 |
| Prosperity Bancshares Inc. | Common and Preferred Stock 1,717 shares | 129376 |
| QuidelOrtho Corporation | Common and Preferred Stock 2,877 shares | 128170 |
| Ultragenyx Pharmaceutical Inc. | Common and Preferred Stock 3,033 shares | 127598 |
| Curtiss Wright Corporation | Common and Preferred Stock 355 shares | 125979 |
| nCino, Inc. | Common and Preferred Stock 3,701 shares | 124280 |
| Toro Company | Common and Preferred Stock 1,514 shares | 121271 |
| Dycom Industries Inc. | Common and Preferred Stock 696 shares | 121146 |
| Belden Inc. | Common and Preferred Stock 1,072 shares | 120718 |
| National Retail Properties Inc. | Common and Preferred Stock 2,937 shares | 119976 |
| ACI Worldwide Inc. | Common and Preferred Stock 2,299 shares | 119341 |
| Copart Inc. | Common and Preferred Stock 2,069 shares | 118740 |
| Mid-American Apartment Communities Inc. | Common and Preferred Stock 759 shares | 117319 |
| Itron Inc. | Common and Preferred Stock 1,071 shares | 116289 |
| FMC Corporation | Common and Preferred Stock 2,288 shares | 111220 |
| Kirby Corporation | Common and Preferred Stock 1,051 shares | 111196 |
| Summit Materials Inc. | Common and Preferred Stock 2,181 shares | 110359 |
| Madrigal Pharmaceuticals, Inc. | Common and Preferred Stock 349 shares | 107691 |
| Advanced Energy Industries Inc. | Common and Preferred Stock 926 shares | 107073 |
| Teleflex Inc. | Common and Preferred Stock 587 shares | 104474 |
| WEX Inc. | Common and Preferred Stock 591 shares | 103614 |
| Permian Resources Corporation | Common and Preferred Stock 7,205 shares | 103608 |
| Alamos Gold Inc. Class A | Common and Preferred Stock 5,570 shares | 102711 |
| IAC Inc. | Common and Preferred Stock 2,366 shares | 102069 |
| Chart Industrials Inc. | Common and Preferred Stock 532 shares | 101527 |
| FTI Consulting Inc. | Common and Preferred Stock 531 shares | 101490 |
| BankUnited Inc. | Common and Preferred Stock 2,657 shares | 101418 |
| John Bean Technologies Corporation | Common and Preferred Stock 789 shares | 100282 |
| Iridium Communications Inc. | Common and Preferred Stock 3,455 shares | 100264 |
| Graco Inc. | Common and Preferred Stock 1,184 shares | 99799 |
| Carlisle Companies Inc. | Common and Preferred Stock 269 shares | 99218 |
| Azekpany Inc. | Common and Preferred Stock 2,080 shares | 98738 |
| TKO Group Holdings Inc. | Common and Preferred Stock 694 shares | 98624 |
| Middleby Corporation | Common and Preferred Stock 720 shares | 97524 |
| Rentokil Initial plc | Common and Preferred Stock 3,739 shares | 94671 |
| Hexcel Corporation | Common and Preferred Stock 1,489 shares | 93360 |
| Certara Inc. | Common and Preferred Stock 8,682 shares | 92463 |
| Cimpress plc | Common and Preferred Stock 1,288 shares | 92375 |
| Chemed Corporation | Common and Preferred Stock 172 shares | 91126 |
| National Bank Holdings Corporation Class A | Common and Preferred Stock 2,098 shares | 90340 |
| Encompass Health Corporation | Common and Preferred Stock 964 shares | 89025 |

---

------

Schedule H, line 4i – Schedule of Assets (Held at End of Year) (continued)

---

| | | |
|:---|:---|:---|
| **Identity of Issue** | **Description of Investment** | **Current Value** |
| Oceaneering International Inc. | Common and Preferred Stock 3,381 shares | 88176 |
| AptarGroup Inc. | Common and Preferred Stock 555 shares | 87191 |
| Supernus Pharmaceuticals Inc. | Common and Preferred Stock 2,411 shares | 87182 |
| Ciena Corporation | Common and Preferred Stock 1,027 shares | 87100 |
| JP Morgan Chase & Company | Common and Preferred Stock 363 shares | 87015 |
| Sotera Health Company | Common and Preferred Stock 6,295 shares | 86116 |
| Range Resources Corporation | Common and Preferred Stock 2,374 shares | 85417 |
| Keysight Technologies Inc. | Common and Preferred Stock 531 shares | 85295 |
| Pool Corporation | Common and Preferred Stock 247 shares | 84212 |
| ASGN Inc. | Common and Preferred Stock 1,003 shares | 83590 |
| On Semiconductor Corporation | Common and Preferred Stock 1,321 shares | 83289 |
| Barnes Group Inc. | Common and Preferred Stock 1,721 shares | 81334 |
| Hannon Armstrong Sustainable Infrastructure Capital Inc. | Common and Preferred Stock 3,019 shares | 81000 |
| Prestige Consumer Healthcare Inc. | Common and Preferred Stock 1,036 shares | 80901 |
| Knowles Corporation | Common and Preferred Stock 4,038 shares | 80477 |
| Federal Signal Corporation | Common and Preferred Stock 857 shares | 79178 |
| Box Inc. Class A | Common and Preferred Stock 2,503 shares | 79095 |
| Omnicell Inc. | Common and Preferred Stock 1,775 shares | 79023 |
| Tenable Holdings Inc. | Common and Preferred Stock 1,998 shares | 78681 |
| KBR, Inc. | Common and Preferred Stock 1,353 shares | 78379 |
| WisdomTree Investments Inc. | Common and Preferred Stock 7,451 shares | 78236 |
| Applied Industrial Technologies Inc. | Common and Preferred Stock 306 shares | 73278 |
| Wolverine World Wide Inc. | Common and Preferred Stock 3,293 shares | 73105 |
| Markel Corporation Holding Company | Common and Preferred Stock 42 shares | 72502 |
| Albany International Corporation Class A | Common and Preferred Stock 901 shares | 72053 |
| Sprout Social, Inc. Class A | Common and Preferred Stock 2,344 shares | 71984 |
| GFL Environmental Inc. | Common and Preferred Stock 1,545 shares | 68814 |
| Haemonetics Corporation | Common and Preferred Stock 868 shares | 67773 |
| Globus Medical, Inc. Class A | Common and Preferred Stock 816 shares | 67491 |
| Sally Beauty Holdings Inc. | Common and Preferred Stock 6,405 shares | 66932 |
| KB Home | Common and Preferred Stock 987 shares | 64866 |
| Core & Main, Inc. Class A | Common and Preferred Stock 1,258 shares | 64045 |
| Teledyne Technologies Inc. | Common and Preferred Stock 136 shares | 63122 |
| SpringWorks Therapeutics Inc. | Common and Preferred Stock 1,747 shares | 63112 |
| Sportradar Group | Common and Preferred Stock 3,490 shares | 60517 |
| Acadia Healthcare Company Inc. | Common and Preferred Stock 1,499 shares | 59435 |
| Elastic N.V. | Common and Preferred Stock 594 shares | 58854 |
| 8X8 Inc. | Common and Preferred Stock 21,091 shares | 56313 |
| Jacobs Solutions Inc. | Common and Preferred Stock 421 shares | 56254 |
| ZipRecruiter Inc. Class A | Common and Preferred Stock 7,539 shares | 54582 |
| Axogen Inc. | Common and Preferred Stock 3,306 shares | 54483 |
| Legend Biotech Corporation | Common and Preferred Stock 1,663 shares | 54114 |
| Agios Pharmaceuticals Inc. | Common and Preferred Stock 1,631 shares | 53595 |
| SLR Investment Corporation | Common and Preferred Stock 3,305 shares | 53409 |
| J & J Snack Foods Corporation | Common and Preferred Stock 344 shares | 53365 |
| Knight-Swift Transportation Holdings Inc. Class A | Common and Preferred Stock 1,004 shares | 53252 |
| Carter Inc. | Common and Preferred Stock 933 shares | 50559 |
| Consensus Cloud Solutions Inc. | Common and Preferred Stock 2,069 shares | 49366 |
| N-Able Technologies International Inc. | Common and Preferred Stock 5,255 shares | 49082 |
| United Community Bank Blairsville Georgia | Common and Preferred Stock 1,514 shares | 48917 |

---

------

Schedule H, line 4i – Schedule of Assets (Held at End of Year) (continued)

---

| | | |
|:---|:---|:---|
| **Identity of Issue** | **Description of Investment** | **Current Value** |
| Matthews International Corporation Class A | Common and Preferred Stock 1,745 shares | 48302 |
| Trinet Group Inc. | Common and Preferred Stock 530 shares | 48108 |
| CONMED Corporation | Common and Preferred Stock 695 shares | 47566 |
| Skechers USA Inc. Class A | Common and Preferred Stock 705 shares | 47404 |
| Nasdaq Inc. | Common and Preferred Stock 612 shares | 47314 |
| Arvinas Inc. | Common and Preferred Stock 2,454 shares | 47043 |
| Tronox Holdings PLC | Common and Preferred Stock 4,666 shares | 46987 |
| Eagle Materials Inc. | Common and Preferred Stock 190 shares | 46884 |
| Banner Corporation | Common and Preferred Stock 681 shares | 45470 |
| Crescent Energy Company Class A | Common and Preferred Stock 3,103 shares | 45335 |
| BRP Group Inc. Class A | Common and Preferred Stock 1,167 shares | 45233 |
| WillScot Mobile Mini Holdings Corporation | Common and Preferred Stock 1,339 shares | 44790 |
| Align Technology Inc. | Common and Preferred Stock 213 shares | 44413 |
| STAG Industrial Inc. | Common and Preferred Stock 1,283 shares | 43391 |
| Heartland Express Inc. | Common and Preferred Stock 3,863 shares | 43343 |
| Axalta Coating Systems Limited | Common and Preferred Stock 1,249 shares | 42741 |
| Cohen & Steers Inc. | Common and Preferred Stock 455 shares | 42015 |
| TreeHouse Foods Inc. | Common and Preferred Stock 1,186 shares | 41664 |
| Matson Inc. | Common and Preferred Stock 308 shares | 41531 |
| Wabtec Corporation | Common and Preferred Stock 216 shares | 40951 |
| Exact Sciences Corporation | Common and Preferred Stock 712 shares | 40007 |
| JBG SMITH Properties | Common and Preferred Stock 2,514 shares | 38640 |
| Pacific Premier Bancorp Inc. | Common and Preferred Stock 1,540 shares | 38377 |
| GXO Logistics Inc. | Common and Preferred Stock 879 shares | 38237 |
| Littelfuse Inc. | Common and Preferred Stock 161 shares | 37940 |
| Silgan Holdings Inc. | Common and Preferred Stock 726 shares | 37788 |
| Northern Oil & Gas Inc. | Common and Preferred Stock 1,016 shares | 37755 |
| Fox Factory Holding Corporation | Common and Preferred Stock 1,246 shares | 37716 |
| Flowserve Corporation | Common and Preferred Stock 632 shares | 36353 |
| First Interstate BancSystem | Common and Preferred Stock 1,095 shares | 35555 |
| Northwestern Corporation | Common and Preferred Stock 609 shares | 32557 |
| ALLETE Inc. | Common and Preferred Stock 499 shares | 32335 |
| Monro Inc. | Common and Preferred Stock 1,299 shares | 32215 |
| WSFS Financial Corporation | Common and Preferred Stock 601 shares | 31931 |
| Healthpeak OP, LLC | Common and Preferred Stock 1,531 shares | 31033 |
| Mercury Systems Inc. | Common and Preferred Stock 730 shares | 30660 |
| Texas Capital Bancshares Inc. | Common and Preferred Stock 392 shares | 30654 |
| Americold Realty Trust, Inc. | Common and Preferred Stock 1,402 shares | 30003 |
| Amentum Holdings, Inc. | Common and Preferred Stock 1,389 shares | 29211 |
| NCR Corporation | Common and Preferred Stock 1,971 shares | 27279 |
| Boston Properties Inc. | Common and Preferred Stock 365 shares | 27141 |
| Dyne Therapeutics, Inc. | Common and Preferred Stock 1,128 shares | 26576 |
| Patterson-UTI Energy Inc. | Common and Preferred Stock 3,203 shares | 26457 |
| 1-800-FLOWERS.COM Inc. Class A | Common and Preferred Stock 3,075 shares | 25123 |
| IPG Photonics Corporation | Common and Preferred Stock 340 shares | 24725 |
| J2 Global Inc. | Common and Preferred Stock 443 shares | 24073 |
| Sonos Inc. | Common and Preferred Stock 1,594 shares | 23974 |
| Nevro Corporation | Common and Preferred Stock 6,419 shares | 23879 |
| StandardAero, Inc. | Common and Preferred Stock 958 shares | 23720 |
| Rogers Corporation | Common and Preferred Stock 228 shares | 23167 |
| Berkshire Hills Bancorp Inc. | Common and Preferred Stock 807 shares | 22943 |

---

------

Schedule H, line 4i – Schedule of Assets (Held at End of Year) (continued)

---

| | | | |
|:---|:---|:---|:---|
| **Identity of Issue** | **Description of Investment** | **Current Value** | **Current Value** |
| Transmedics Group Inc. | Common and Preferred Stock 338 shares | 21074 |  |
| Mednax Inc. | Common and Preferred Stock 1,508 shares | 19785 |  |
| Nuvalent, Inc. Class A | Common and Preferred Stock 250 shares | 19570 |  |
| Columbus McKinnon Corporation | Common and Preferred Stock 443 shares | 16497 |  |
| Insight Enterprises, Inc. | Common and Preferred Stock 108 shares | 16427 |  |
| Designer Brands Inc. Class A | Common and Preferred Stock 2,990 shares | 15967 |  |
| Herbalife Nutrition Limited | Common and Preferred Stock 2,136 shares | 14290 |  |
| eHealth Inc. | Common and Preferred Stock 1,190 shares | 11186 |  |
| Nu Skin Enterprises Inc. Class A | Common and Preferred Stock 1,211 shares | 8344 |  |
| Safehold Inc. | Common and Preferred Stock 435 shares | 8039 |  |
| Total U.S. Equity Active Asset Class |  |  | 63615336 |
| U.S. Equity Index Asset Class: |  |  |  |
| NT Collective Russell 3000 Index Fund / Non Lending\* | Collective Trust Fund 1,899,107 units | 176320690 |  |
| NT Collective Short Term Investment Fund\* | Collective Trust Fund 25 units | 25 |  |
| Total U.S. Equity Index Asset Class |  |  | 176320715 |
| International Equity Active Asset Class: |  |  |  |
| Mawer International Equity Collective Investment Trust Class B\* | Collective Trust Fund 1,575,932 units | 27927716 |  |
| Polaris Capital Management Collective Investment Trust International Value Collective Fund\* | Collective Trust Fund 2,211,444 units | 26838086 |  |
| Reliance Trust Institutional Retirement Trust GQG Partners International Equity Fund Series 11 Class C\* | Collective Trust Fund 1,278,791 units | 20371142 |  |
| Dodge & Cox International Stock Fund | Mutual Fund 324,627 shares | 16198902 |  |
| Wilmington Trust Collective Investment Trust / Jennison International Equity Opportunities CIT Class J\* | Collective Trust Fund 1,573,351 units | 15746099 |  |
| NT Collective MSCI All Country World Index (ACWI) ex/US Index Fund / Non Lending\* | Collective Trust Fund 47,044 units | 10619923 |  |
| NT Collective Short Term Investment Fund\* | Collective Trust Fund 3,996 units | 3996 |  |
| Total International Equity Active Asset Class |  |  | 117705864 |
| International Equity Index Asset Class: |  |  |  |
| NT Collective MSCI All Country World Index (ACWI) ex/US Index Fund / Non Lending\* | Collective Trust Fund 123,364 units | 25422921 |  |
| Total International Equity Index Asset Class |  |  | 25422921 |
| Participant Self-Directed Accounts | Various Investments | 19625736 |  |
|  |  |  | 19625736 |
| Notes Receivable from Participants\* | Interest Rate 4.25% - 9.50% | 17220197 |  |
|  |  |  | 17220197 |
| Other |  |  |  |
| ML Vanguard Federal Money Market Forfeiture / Settlement\* | Cash and Cash Equivalents | 34702 |  |
| BIF Money Fund\* | Cash and Cash Equivalents | 9000 |  |
| NT Collective Short Term Investment Fund\* | Collective Trust Fund 2,031 units | 2031 |  |
| Total Other |  |  | 45733 |

---

------

Schedule H, line 4i – Schedule of Assets (Held at End of Year) (continued)

---

| | | |
|:---|:---|:---|
| **Identity of Issue** | **Description of Investment** | **Current Value** |
| Grand Total |  | $779230400 |

---

 <br> \* Indicates party-in-interest

------

**RETIREMENT AND SAVINGS PLAN FOR** 

**AMGEN MANUFACTURING LIMITED LLC**

**INDEX TO EXHIBIT**

<u>[Consent of Independent Registered Public Accounting Firm](amgn-ex231_20241231xpuerto.htm)</u> Exhibit 23.1

------

**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the trustees (or other persons who administer the employee benefit plan) have duly caused this annual report to be signed on its behalf by the undersigned hereunto duly authorized.

---

| | | | |
|:---|:---|:---|:---|
| | | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Retirement and Savings Plan for Amgen Manufacturing Limited LLC<br> (Name of Plan) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Retirement and Savings Plan for Amgen Manufacturing Limited LLC<br> (Name of Plan) |
| Date: | June 12, 2025 | By: | &nbsp;&nbsp;&nbsp;/s/ PETER H. GRIFFITH |
|  |  |  | &nbsp;&nbsp;&nbsp;Peter H. Griffith |
|  |  |  | &nbsp;&nbsp;Executive Vice President and Chief Financial Officer |
|  |  |  | &nbsp;&nbsp;Amgen Manufacturing Limited LLC |

---

## Exhibit 23.1

**Exhibit 23.1**

**CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM**

We consent to the incorporation by reference in the Registration Statements (Form S-8 Nos. 33-47605, 333-144580 and 333-216715) pertaining to the Retirement and Savings Plan for Amgen Manufacturing Limited LLC of Amgen Inc. of our report dated June 12, 2025, with respect to the financial statements and schedule of the Retirement and Savings Plan for Amgen Manufacturing Limited LLC included in this Annual Report (Form 11-K) for the year ended December 31, 2024.

/s/ ERNST & YOUNG LLP

Los Angeles, California

June 12, 2025

<br>