# EDGAR Filing Document

**Accession Number:** 0001002624
**File Stem:** 0001002624-25-000032
**Filing Date:** 2025-8
**Character Count:** 84103
**Document Hash:** 88510db30c8af3a9b7f7cef5da9521ca
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001002624-25-000032.hdr.sgml**: 20250826

**ACCESSION NUMBER**: 0001002624-25-000032

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20250630

**FILED AS OF DATE**: 20250826

**DATE AS OF CHANGE**: 20250826

**PERIOD START**: 20251231

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** T. Rowe Price Health Sciences Fund, Inc.
- **CENTRAL INDEX KEY:** 0001002624

**ORGANIZATION NAME:**
- **EIN:** 521952906
- **STATE OF INCORPORATION:** MD
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-07381
- **FILM NUMBER:** 251256838

**BUSINESS ADDRESS:**
- **STREET 1:** 1307 POINT STREET
- **CITY:** BALTIMORE
- **STATE:** MD
- **ZIP:** 21231
- **BUSINESS PHONE:** 410-345-2000

**MAIL ADDRESS:**
- **STREET 1:** 1307 POINT STREET
- **CITY:** BALTIMORE
- **STATE:** MD
- **ZIP:** 21231

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** PRICE T ROWE HEALTH SCIENCES FUND INC
- **DATE OF NAME CHANGE:** 19980513

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** PRICE T ROWE HEALTH & LIFE SCIENCES FUND INC
- **DATE OF NAME CHANGE:** 19951023

## Series and Classes Contracts Data

### T. Rowe Price Health Sciences Fund, Inc. (Series ID: S000002088)

| Class ID   | Class Name                                 | Ticker Symbol   |
|:---|:---|:---|
| C000005456 | T. Rowe Price Health Sciences Fund, Inc.   | PRHSX           |
| C000169937 | T. Rowe Price Health Sciences Fund-I Class | THISX           |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** T. ROWE PRICE HEALTH SCIENCES FUND, INC.

- **b. Investment Company Act file number:** 811-07381

- **c. CIK number of Registrant:** 0001002624

- **d. LEI of Registrant:** 549300ELV6FPY6UQBJ78

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 1307 Point Street

  - **City:** Baltimore

  - **State:** MD

  - **Foreign country:** US

  - **Zip / Postal Code:** 21231

  - **Telephone number:** 410-345-2000

**Item A.2. Information about the Series.**

- **a. Name of Series:** T. Rowe Price Health Sciences Fund, Inc.

- **b. EDGAR series identifier (if any):** S000002088

- **c. LEI of Series:** 66LP7EMLZS5S33LWIH41

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2025-12-31

- **b. Date as of which information is reported:** 2025-06-30

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $11310905442.60

**Total Liabilities:** $7685234.55

**Net Assets:** $11303220208.05

**Assets Attributable to Miscellaneous Securities:** $375543701.93

**Cash Not Reported:** $645244.53

**Currency Risk Metrics (dv01):**

- 

**Credit Spread Risk - Investment Grade (dv01):**

- **3-Month:** 0.000000 | **1-Year:** 0.000000 | **5-Year:** 0.000000 | **10-Year:** 0.000000 | **30-Year:** 0.000000

**Credit Spread Risk - Non-Investment Grade (dv01):**

- **3-Month:** 0.000000 | **1-Year:** 0.000000 | **5-Year:** 0.000000 | **10-Year:** 0.000000 | **30-Year:** 0.000000

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000005456 | -0.09%               | -6.50%               | 3.99%                |
| Class ID C000169937 | -0.06%               | -6.49%               | 3.99%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $73507559.48             | $-86582152.19                              |
| Month 2  | $141145057.48            | $-921654173.71                             |
| Month 3  | $117428684.13            | $314923627.00                              |

### Schedule of Portfolio Investments

| Name                                  | Title                                              | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)    | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| AbbVie Inc                            | ABBVIE INC                                         | CUSIP: 00287Y109<br>LEI: FR5LCKFTG8054YNNRU85 | Long             | EC               | CORP              | US        |   1068045 | NS      | $198250512.90  | 1.75%             |  |  |  | No            |                  1 | On Loan: No      |
| Spyre Therapeutics Inc                | SPYRE THERAPEUTICS INC                             | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |    690693 | NS      | $10339674.21   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Agios Pharmaceuticals Inc             | AGIOS PHARMACEUTICALS INC                          | CUSIP: 00847X104<br>LEI: 529900ONJHY8EOGYT555 | Long             | EC               | CORP              | US        |    990652 | NS      | $32949085.52   | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Akero Therapeutics Inc                | AKERO THERAPEUTICS INC                             | CUSIP: 00973Y108<br>LEI: 549300SI3KG74LBE2955 | Long             | EC               | CORP              | US        |   1114732 | NS      | $59482099.52   | 0.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Alector Inc                           | ALECTOR INC                                        | CUSIP: 014442107<br>LEI: 549300Z8RQOIY1JMHC25 | Long             | EC               | CORP              | US        |   3792774 | NS      | $5309883.60    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Allogene Therapeutics Inc             | ALLOGENE THERAPEUTICS INC                          | CUSIP: 019770106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2751488 | NS      | $3109181.44    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals Inc           | ALNYLAM PHARMACEUTICALS INC                        | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |   1015552 | NS      | $331161351.68  | 2.93%             |  |  |  | No            |                  1 | On Loan: No      |
| Cencora Inc                           | CENCORA INC                                        | CUSIP: 03073E105<br>LEI: AI8GXW8LG5WK7E9UD086 | Long             | EC               | CORP              | US        |    292915 | NS      | $87830562.75   | 0.78%             |  |  |  | No            |                  1 | On Loan: No      |
| Amgen Inc                             | AMGEN INC                                          | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |     62105 | NS      | $17340337.05   | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Annexon Inc                           | ANNEXON INC                                        | CUSIP: 03589W102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    258836 | NS      | $621206.40     | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Elevance Health Inc                   | ELEVANCE HEALTH INC                                | CUSIP: 036752103<br>LEI: 8MYN82XMYQH89CTMTH67 | Long             | EC               | CORP              | US        |    561120 | NS      | $218253235.20  | 1.93%             |  |  |  | No            |                  1 | On Loan: No      |
| Apogee Therapeutics Inc               | APOGEE THERAPEUTICS INC                            | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    552027 | NS      | $23974532.61   | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcellx Inc                           | ARCELLX INC                                        | CUSIP: 03940C100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    411543 | NS      | $27100106.55   | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Argenx SE                             | ARGENX SE                                          | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |    683183 | NS      | $376584133.26  | 3.33%             |  |  |  | No            |                  1 | On Loan: No      |
| Arvinas Inc                           | ARVINAS INC                                        | CUSIP: 04335A105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    135859 | NS      | $999922.24     | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Ascendis Pharma A/S                   | ASCENDIS PHARMA A/S                                | CUSIP: 04351P101<br>LEI: 549300B66JN3W3J8GH73 | Long             | EC               | CORP              | DK        |    693353 | NS      | $119672727.80  | 1.06%             |  |  |  | No            |                  1 | On Loan: No      |
| AstraZeneca PLC                       | ASTRAZENECA PLC                                    | CUSIP: 046353108<br>LEI: PY6ZZQWO2IZFZC3IOL08 | Long             | EC               | CORP              | GB        |   1925605 | NS      | $134561277.40  | 1.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Aura Biosciences Inc                  | AURA BIOSCIENCES INC                               | CUSIP: 05153U107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    327622 | NS      | $2050913.72    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Avidity Biosciences Inc               | AVIDITY BIOSCIENCES INC                            | CUSIP: 05370A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2297724 | NS      | $65255361.60   | 0.58%             |  |  |  | No            |                  1 | On Loan: No      |
| Beam Therapeutics Inc                 | BEAM THERAPEUTICS INC                              | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    912997 | NS      | $15530078.97   | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| BeOne Medicines Ltd                   | BEONE MEDICINES LTD                                | CUSIP: 07725L102<br>LEI: 549300JFUK6FRD5MH739 | Long             | EC               | CORP              | KY        |     20455 | NS      | $4951541.85    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Bicycle Therapeutics PLC              | BICYCLE THERAPEUTICS PLC                           | CUSIP: 088786108<br>LEI: 213800XKUI6R7GKC3E43 | Long             | EC               | CORP              | GB        |   1094999 | NS      | $7610243.05    | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Blueprint Medicines Corp              | BLUEPRINT MEDICINES CORP                           | CUSIP: 09627Y109<br>LEI: 5299004CC60O9T5HVM83 | Long             | EC               | CORP              | US        |    468745 | NS      | $60083734.10   | 0.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Boston Scientific Corp                | BOSTON SCIENTIFIC CORP                             | CUSIP: 101137107<br>LEI: Y6ZDD9FP4P8JSSJMW954 | Long             | EC               | CORP              | US        |   3879585 | NS      | $416706224.85  | 3.69%             |  |  |  | No            |                  1 | On Loan: No      |
| BrightSpring Health Services Inc      | BRIGHTSPRING HEALTH SERVICES INC                   | CUSIP: 10950A106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1859258 | NS      | $43859896.22   | 0.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Cigna Group/The                       | CIGNA GROUP/THE                                    | CUSIP: 125523100<br>LEI: 549300VIWYMSIGT1U456 | Long             | EC               | CORP              | US        |    720172 | NS      | $238074459.76  | 2.11%             |  |  |  | No            |                  1 | On Loan: No      |
| CVS Health Corp                       | CVS HEALTH CORP                                    | CUSIP: 126650100<br>LEI: 549300EJG376EN5NQE29 | Long             | EC               | CORP              | US        |    989715 | NS      | $68270540.70   | 0.60%             |  |  |  | No            |                  1 | On Loan: No      |
| Cabaletta Bio Inc                     | CABALETTA BIO INC                                  | CUSIP: 12674W109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1944763 | NS      | $2956039.76    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Cardinal Health Inc                   | CARDINAL HEALTH INC                                | CUSIP: 14149Y108<br>LEI: CCU46N3GJMF4OK4N7U60 | Long             | EC               | CORP              | US        |    316322 | NS      | $53142096.00   | 0.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Cargo Therapeutics Inc                | CARGO THERAPEUTICS INC                             | CUSIP: 14179K101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    426331 | NS      | $1756483.72    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Caris Life Sciences Inc               | CARIS LIFE SCIENCES INC                            | CUSIP: 142152107<br>LEI: 549300LX5LO78M5VPY43 | Long             | EC               | CORP              | US        |    285603 | NS      | $7631312.16    | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Celldex Therapeutics Inc              | CELLDEX THERAPEUTICS INC                           | CUSIP: 15117B202<br>LEI: 529900F018DMYWH38923 | Long             | EC               | CORP              | US        |    750770 | NS      | $15278169.50   | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Centessa Pharmaceuticals PLC          | CENTESSA PHARMACEUTICALS PLC                       | CUSIP: 152309100<br>LEI: 213800GIDAARDSKOI827 | Long             | EC               | CORP              | GB        |   3207428 | NS      | $42145603.92   | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| CG oncology Inc                       | CG ONCOLOGY INC                                    | CUSIP: 156944100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1199738 | NS      | $31193188.00   | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Crinetics Pharmaceuticals Inc         | CRINETICS PHARMACEUTICALS INC                      | CUSIP: 22663K107<br>LEI: 549300Q1CNFXK5P31D28 | Long             | EC               | CORP              | US        |   1053066 | NS      | $30286178.16   | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytokinetics Inc                      | CYTOKINETICS INC                                   | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |    337628 | NS      | $11155229.12   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Danaher Corp                          | DANAHER CORP                                       | CUSIP: 235851102<br>LEI: S4BKK9OTCEWQ3YHPFM11 | Long             | EC               | CORP              | US        |   1772356 | NS      | $350111204.24  | 3.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Denali Therapeutics Inc               | DENALI THERAPEUTICS INC                            | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |   2502127 | NS      | $35004756.73   | 0.31%             |  |  |  | No            |                  1 | On Loan: No      |
| Dexcom Inc                            | DEXCOM INC                                         | CUSIP: 252131107<br>LEI: 549300YSK3QDSFR5EU59 | Long             | EC               | CORP              | US        |    322061 | NS      | $28112704.69   | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Disc Medicine Inc                     | DISC MEDICINE INC                                  | CUSIP: 254604101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    309390 | NS      | $16385294.40   | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Encompass Health Corp                 | ENCOMPASS HEALTH CORP                              | CUSIP: 29261A100<br>LEI: 549300FVRPM9DRQZRG64 | Long             | EC               | CORP              | US        |    187885 | NS      | $23040337.55   | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Entrada Therapeutics Inc              | ENTRADA THERAPEUTICS INC                           | CUSIP: 29384C108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    219570 | NS      | $1475510.40    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Exact Sciences Corp                   | EXACT SCIENCES CORP                                | CUSIP: 30063P105<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |   1018911 | NS      | $54144930.54   | 0.48%             |  |  |  | No            |                  1 | On Loan: No      |
| Generation Bio Co                     | GENERATION BIO CO                                  | CUSIP: 37148K100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1428551 | NS      | $457279.18     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Gilead Sciences Inc                   | GILEAD SCIENCES INC                                | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |   2454960 | NS      | $272181415.20  | 2.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Ginkgo Bioworks Holdings Inc          | GINKGO BIOWORKS HOLDINGS INC                       | CUSIP: 37611X209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     28555 | NS      | $321243.75     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| HCA Healthcare Inc                    | HCA HEALTHCARE INC                                 | CUSIP: 40412C101<br>LEI: 529900PH4ZGUH2MNEU89 | Long             | EC               | CORP              | US        |    224900 | NS      | $86159190.00   | 0.76%             |  |  |  | No            |                  1 | On Loan: No      |
| Ideaya Biosciences Inc                | IDEAYA BIOSCIENCES INC                             | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |    171812 | NS      | $3611488.24    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| IDEXX Laboratories Inc                | IDEXX LABORATORIES INC                             | CUSIP: 45168D104<br>LEI: OGMTXK0LUU1HKV2P0J84 | Long             | EC               | CORP              | US        |     77131 | NS      | $41368440.54   | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Immunome Inc                          | IMMUNOME INC                                       | CUSIP: 45257U108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2186824 | NS      | $20337463.20   | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Immunocore Holdings PLC               | IMMUNOCORE HOLDINGS PLC                            | CUSIP: 45258D105<br>LEI: 213800IUE3DFS84BVN18 | Long             | EC               | CORP              | GB        |    773698 | NS      | $24278643.24   | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Immunocore Holdings PLC               | IMMUNOCORE HOLDINGS PLC                            | CUSIP: 45258DAB1<br>LEI: 213800IUE3DFS84BVN18 | Long             | DBT              | CORP              | GB        |  15469000 | PA      | $13290299.63   | 0.12%             | 2030-02-01      | Fixed         | 2.50%                 | No            |                  2 | On Loan: No      |
| Insmed Inc                            | INSMED INC                                         | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |   2410557 | NS      | $242598456.48  | 2.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Intuitive Surgical Inc                | INTUITIVE SURGICAL INC                             | CUSIP: 46120E602<br>LEI: 54930052SRG011710797 | Long             | EC               | CORP              | US        |   1209176 | NS      | $657078330.16  | 5.81%             |  |  |  | No            |                  1 | On Loan: No      |
| Ionis Pharmaceuticals Inc             | IONIS PHARMACEUTICALS INC                          | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |    512286 | NS      | $20240419.86   | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Iovance Biotherapeutics Inc           | IOVANCE BIOTHERAPEUTICS INC                        | CUSIP: 462260100<br>LEI: 2549002L8WT2ACU5Q878 | Long             | EC               | CORP              | US        |    737385 | NS      | $1268302.20    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Janux Therapeutics Inc                | JANUX THERAPEUTICS INC                             | CUSIP: 47103J105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    372178 | NS      | $8597311.80    | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Krystal Biotech Inc                   | KRYSTAL BIOTECH INC                                | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |    118808 | NS      | $16331347.68   | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Kymera Therapeutics Inc               | KYMERA THERAPEUTICS INC                            | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1366008 | NS      | $59612589.12   | 0.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Kyverna Therapeutics Inc              | KYVERNA THERAPEUTICS INC                           | CUSIP: 501976104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1382457 | NS      | $4244142.99    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Lantheus Holdings Inc                 | LANTHEUS HOLDINGS INC                              | CUSIP: 516544103<br>LEI: 5299005HUB5IOJGO7S39 | Long             | EC               | CORP              | US        |    122002 | NS      | $9987083.72    | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Legend Biotech Corp                   | LEGEND BIOTECH CORP                                | CUSIP: 52490G102<br>LEI: 254900EIUFZTW136H859 | Long             | EC               | CORP              | KY        |    601652 | NS      | $21352629.48   | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Eli Lilly & Co                        | ELI LILLY & CO                                     | CUSIP: 532457108<br>LEI: FRDRIPF3EKNDJ2CQJL29 | Long             | EC               | CORP              | US        |   1729504 | NS      | $1348200253.12 | 11.93%            |  |  |  | No            |                  1 | On Loan: No      |
| Lyell Immunopharma Inc                | LYELL IMMUNOPHARMA INC                             | CUSIP: 55083R203<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    214565 | NS      | $1896754.60    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Madrigal Pharmaceuticals Inc          | MADRIGAL PHARMACEUTICALS INC                       | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |    135801 | NS      | $41098814.64   | 0.36%             |  |  |  | No            |                  1 | On Loan: No      |
| McKesson Corp                         | MCKESSON CORP                                      | CUSIP: 58155Q103<br>LEI: 549300WZWOM80UCFSF54 | Long             | EC               | CORP              | US        |     14842 | NS      | $10875920.76   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Sartorius AG                          | SARTORIUS AG                                       | CUSIP: 000000000<br>LEI: 529900EQV2DY4FOAMU38 | Long             | EP               | CORP              | DE        |     89300 | NS      | $22744515.33   | 0.20%             |  |  |  | No            |                  2 | On Loan: No      |
| Molina Healthcare Inc                 | MOLINA HEALTHCARE INC                              | CUSIP: 60855R100<br>LEI: 549300NQQCEQ46YHZ591 | Long             | EC               | CORP              | US        |    244877 | NS      | $72948858.30   | 0.65%             |  |  |  | No            |                  1 | On Loan: No      |
| Monte Rosa Therapeutics Inc           | MONTE ROSA THERAPEUTICS INC                        | CUSIP: 61225M102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    947439 | NS      | $4272949.89    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| MoonLake Immunotherapeutics           | MOONLAKE IMMUNOTHERAPEUTICS                        | CUSIP: 61559X104<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |   1096693 | NS      | $51763909.60   | 0.46%             |  |  |  | No            |                  1 | On Loan: No      |
| Chugai Pharmaceutical Co Ltd          | CHUGAI PHARMACEUTICAL CO LTD                       | CUSIP: 000000000<br>LEI: 529900T9LAII161DCN95 | Long             | EC               | CORP              | JP        |   2324600 | NS      | $121385556.21  | 1.07%             |  |  |  | No            |                  2 | On Loan: No      |
| Natera Inc                            | NATERA INC                                         | CUSIP: 632307104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    573317 | NS      | $96856173.98   | 0.86%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences Inc            | NEUROCRINE BIOSCIENCES INC                         | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |    621659 | NS      | $78136319.71   | 0.69%             |  |  |  | No            |                  1 | On Loan: No      |
| Orchestra BioMed Holdings Inc         | ORCHESTRA BIOMED HOLDINGS INC                      | CUSIP: 68572M106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    290668 | NS      | $778990.24     | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| ORIC Pharmaceuticals Inc              | ORIC PHARMACEUTICALS INC                           | CUSIP: 68622P109<br>LEI: 54930033FJRNEYBW0L25 | Long             | EC               | CORP              | US        |   1028438 | NS      | $10438645.70   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Oruka Therapeutics Inc                | ORUKA THERAPEUTICS INC                             | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |    257030 | NS      | $2881306.30    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Oscar Health Inc                      | OSCAR HEALTH INC                                   | CUSIP: 687793109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    383141 | NS      | $8214543.04    | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Penumbra Inc                          | PENUMBRA INC                                       | CUSIP: 70975L107<br>LEI: 549300RGE06P3ECANU72 | Long             | EC               | CORP              | US        |    639140 | NS      | $164022498.20  | 1.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Revvity Inc                           | REVVITY INC                                        | CUSIP: 714046109<br>LEI: 549300IKL1SDPFI7N655 | Long             | EC               | CORP              | US        |    401827 | NS      | $38864707.44   | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Sonova Holding AG                     | SONOVA HOLDING AG                                  | CUSIP: 000000000<br>LEI: 5299004A0QNX7FBNHS61 | Long             | EC               | CORP              | CH        |    182689 | NS      | $54482516.51   | 0.48%             |  |  |  | No            |                  2 | On Loan: No      |
| Praxis Precision Medicines Inc        | PRAXIS PRECISION MEDICINES INC                     | CUSIP: 74006W207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    374760 | NS      | $15758658.00   | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Prelude Therapeutics Inc              | PRELUDE THERAPEUTICS INC                           | CUSIP: 74065P101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    661222 | NS      | $535193.09     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| PROCEPT BioRobotics Corp              | PROCEPT BIOROBOTICS CORP                           | CUSIP: 74276L105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    699487 | NS      | $40290451.20   | 0.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Protagonist Therapeutics Inc          | PROTAGONIST THERAPEUTICS INC                       | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    685458 | NS      | $37885263.66   | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Quest Diagnostics Inc                 | QUEST DIAGNOSTICS INC                              | CUSIP: 74834L100<br>LEI: 8MCWUBXQ0WE04KMXBX50 | Long             | EC               | CORP              | US        |    406310 | NS      | $72985465.30   | 0.65%             |  |  |  | No            |                  1 | On Loan: No      |
| Rapport Therapeutics Inc              | RAPPORT THERAPEUTICS INC                           | CUSIP: 75383L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1176835 | NS      | $13380613.95   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Regeneron Pharmaceuticals Inc         | REGENERON PHARMACEUTICALS INC                      | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |    226254 | NS      | $118783350.00  | 1.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Relay Therapeutics Inc                | RELAY THERAPEUTICS INC                             | CUSIP: 75943R102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    569278 | NS      | $1969701.88    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Repligen Corp                         | REPLIGEN CORP                                      | CUSIP: 759916109<br>LEI: 54930006QJ0T5AUO1E71 | Long             | EC               | CORP              | US        |    370690 | NS      | $46106422.20   | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Replimune Group Inc                   | REPLIMUNE GROUP INC                                | CUSIP: 76029N106<br>LEI: 549300AY704NEIRC4K64 | Long             | EC               | CORP              | US        |   1894857 | NS      | $17603221.53   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| T. Rowe Price Government Reserve Fund | T. Rowe Price Government Reserve Fund              | CUSIP: 76105Y109<br>LEI: 5493002Y0IYARJVQ5N24 | Long             | STIV             | RF                | US        |  74108571 | NS      | $74108571.25   | 0.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Revolution Medicines Inc              | REVOLUTION MEDICINES INC                           | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |   1375548 | NS      | $50606410.92   | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Revolution Medicines Inc              | REVOLUTION MEDICINES INC                           | CUSIP: 76155X118<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |    198505 | NS      | $53596.35      | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Rhythm Pharmaceuticals Inc            | RHYTHM PHARMACEUTICALS INC                         | CUSIP: 76243J105<br>LEI: 529900JPNWXQ8DPLA551 | Long             | EC               | CORP              | US        |    324259 | NS      | $20489926.21   | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Rocket Pharmaceuticals Inc            | ROCKET PHARMACEUTICALS INC                         | CUSIP: 77313F106<br>LEI: 549300R7VV82YUIN4Y93 | Long             | EC               | CORP              | US        |    688253 | NS      | $1686219.85    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Sana Biotechnology Inc                | SANA BIOTECHNOLOGY INC                             | CUSIP: 799566104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1743711 | NS      | $4760331.03    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Sanofi SA                             | SANOFI SA                                          | CUSIP: 80105N105<br>LEI: 549300E9PC51EN656011 | Long             | EC               | CORP              | FR        |   1296484 | NS      | $62633142.04   | 0.55%             |  |  |  | No            |                  1 | On Loan: No      |
| Scholar Rock Holding Corp             | SCHOLAR ROCK HOLDING CORP                          | CUSIP: 80706P103<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |   1965921 | NS      | $69632921.82   | 0.62%             |  |  |  | No            |                  1 | On Loan: No      |
| GeneDx Holdings Corp                  | GENEDX HOLDINGS CORP                               | CUSIP: 81663L119<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    206747 | NS      | $13645.30      | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Soleno Therapeutics Inc               | SOLENO THERAPEUTICS INC                            | CUSIP: 834203309<br>LEI: 5493003LCY77N7FXK844 | Long             | EC               | CORP              | US        |    586455 | NS      | $49133199.90   | 0.43%             |  |  |  | No            |                  1 | On Loan: No      |
| SomaLogic Inc                         | SOMALOGIC INC                                      | CUSIP: 83444K113<br>LEI: 549300D3W3Q8CN30YO25 | Long             | EC               | CORP              | US        |     90179 | NS      | $1037.06       | 0.00%             |  |  |  | No            |                  2 | On Loan: No      |
| Stryker Corp                          | STRYKER CORP                                       | CUSIP: 863667101<br>LEI: 5493002F0SC4JTBU5137 | Long             | EC               | CORP              | US        |   1424057 | NS      | $563399670.91  | 4.98%             |  |  |  | No            |                  1 | On Loan: No      |
| Structure Therapeutics Inc            | STRUCTURE THERAPEUTICS INC                         | CUSIP: 86366E106<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |    251171 | NS      | $5209286.54    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Summit Therapeutics Inc               | SUMMIT THERAPEUTICS INC                            | CUSIP: 86627T108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2747413 | NS      | $58464948.64   | 0.52%             |  |  |  | No            |                  1 | On Loan: No      |
| Tarsus Pharmaceuticals Inc            | TARSUS PHARMACEUTICALS INC                         | CUSIP: 87650L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    263625 | NS      | $10679448.75   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Tenet Healthcare Corp                 | TENET HEALTHCARE CORP                              | CUSIP: 88033G407<br>LEI: 0W9AIBT6U6ADJ2I8HK17 | Long             | EC               | CORP              | US        |    610511 | NS      | $107449936.00  | 0.95%             |  |  |  | No            |                  1 | On Loan: No      |
| Thermo Fisher Scientific Inc          | THERMO FISHER SCIENTIFIC INC                       | CUSIP: 883556102<br>LEI: HCHV7422L5HDJZCRFL38 | Long             | EC               | CORP              | US        |    854687 | NS      | $346541391.02  | 3.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Ultragenyx Pharmaceutical Inc         | ULTRAGENYX PHARMACEUTICAL INC                      | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |    703570 | NS      | $25581805.20   | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| United Therapeutics Corp              | UNITED THERAPEUTICS CORP                           | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |     61706 | NS      | $17731219.10   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| UnitedHealth Group Inc                | UNITEDHEALTH GROUP INC                             | CUSIP: 91324P102<br>LEI: 549300GHBMY8T5GXDE41 | Long             | EC               | CORP              | US        |   1842099 | NS      | $574679625.03  | 5.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Vaxcyte Inc                           | VAXCYTE INC                                        | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |   1508403 | NS      | $49038181.53   | 0.43%             |  |  |  | No            |                  1 | On Loan: No      |
| Veeva Systems Inc                     | VEEVA SYSTEMS INC                                  | CUSIP: 922475108<br>LEI: 549300YZEXPDB92M2F02 | Long             | EC               | CORP              | US        |    149336 | NS      | $43005781.28   | 0.38%             |  |  |  | No            |                  1 | On Loan: No      |
| Vera Therapeutics Inc                 | VERA THERAPEUTICS INC                              | CUSIP: 92337R101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1169913 | NS      | $27563150.28   | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Verona Pharma PLC                     | VERONA PHARMA PLC                                  | CUSIP: 925050106<br>LEI: 213800EVI6O6J3TIAL06 | Long             | EC               | CORP              | GB        |   1357044 | NS      | $128349221.52  | 1.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals Inc            | VERTEX PHARMACEUTICALS INC                         | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |    973911 | NS      | $433585177.20  | 3.84%             |  |  |  | No            |                  1 | On Loan: No      |
| Voyager Therapeutics Inc              | VOYAGER THERAPEUTICS INC                           | CUSIP: 92915B106<br>LEI: 54930082S4XVR0ZWCC74 | Long             | EC               | CORP              | US        |    350448 | NS      | $1089893.28    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Xencor Inc                            | XENCOR INC                                         | CUSIP: 98401F105<br>LEI: 549300V5IF65437JKG30 | Long             | EC               | CORP              | US        |    560805 | NS      | $4407927.30    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Zai Lab Ltd                           | ZAI LAB LTD                                        | CUSIP: 98887Q104<br>LEI: 549300P2UYQ9U5LY1T58 | Long             | EC               | CORP              | KY        |    122117 | NS      | $4270431.49    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Alkermes PLC                          | ALKERMES PLC                                       | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | IE        |   1253625 | NS      | $35866211.25   | 0.32%             |  |  |  | No            |                  1 | On Loan: No      |
| ICON PLC                              | ICON PLC                                           | CUSIP: 000000000<br>LEI: 6354008SRQGEMC4XFI67 | Long             | EC               | CORP              | IE        |     65434 | NS      | $9517375.30    | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Pharvaris NV                          | PHARVARIS NV                                       | CUSIP: 000000000<br>LEI: 9845003BE146D3B75D32 | Long             | EC               | CORP              | NL        |    600613 | NS      | $10570788.80   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Biohaven Ltd                          | BIOHAVEN LTD                                       | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | VG        |   1709087 | NS      | $24115217.57   | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Helix Acquisition Corp II             | HELIX ACQUISITION CORP II                          | CUSIP: G4444H101<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |    878945 | NS      | $9360764.25    | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| BeOne Medicines Ltd                   | BEONE MEDICINES LTD                                | CUSIP: 000000000<br>LEI: 549300JFUK6FRD5MH739 | Long             | EC               | CORP              | CH        |   8186296 | NS      | $154860540.10  | 1.37%             |  |  |  | No            |                  2 | On Loan: No      |
| Sensorion SA                          | SENSORION SA                                       | CUSIP: 000000000<br>LEI: 969500P0W8XJ9CGZDP97 | Long             | EC               | CORP              | FR        |  10026597 | NS      | $3692420.65    | 0.03%             |  |  |  | No            |                  2 | On Loan: No      |
| WaVe Life Sciences Ltd                | WAVE LIFE SCIENCES LTD                             | CUSIP: 000000000<br>LEI: 54930070006GPKFYZ813 | Long             | EC               | CORP              | SG        |   1073306 | NS      | $6976489.00    | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Merus NV                              | MERUS NV                                           | CUSIP: 000000000<br>LEI: 549300W8GPUWU8QNU293 | Long             | EC               | CORP              | NL        |    444988 | NS      | $23406368.80   | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                   | CABALETTA BIO COMMON WTS 09/26 PP                  | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1694355 | NS      | $1108616.48    | 0.01%             |  |  |  | Yes           |                  2 | On Loan: No      |
| N/A                                   | EIKON THERA SERIES B-1 CVT PFD STOCK PP            | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    774266 | NS      | $4525157.38    | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | GENESIS THERA SER A CVT PFD STOCK PP               | CUSIP: TC08XH789<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    829412 | NS      | $4236304.73    | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | AKTIS ONCOLOGY SER B CVTPFD PP                     | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   2757866 | NS      | $11031464.00   | 0.10%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | Sionna Therapeutics, Inc. IPO Common Stock lockup  | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    494107 | NS      | $8572756.45    | 0.08%             |  |  |  | Yes           |                  2 | On Loan: No      |
| N/A                                   | OBSIDIAN THERAPEUTICS SR C CVT PFD STK PP          | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   4647794 | NS      | $8821048.23    | 0.08%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | ODYSSEY THERAPEUTICS SR C CVT PFD STK PP           | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    105905 | NS      | $159383.85     | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | KARDIUM SERIES D6 CVT PFD STOCK PP                 | CUSIP: TC0GUUWU8<br>LEI: N/A                  | Long             | EP               | CORP              | US        |  12320393 | NS      | $10193893.17   | 0.09%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | END EAVOR BIO SERIES B CVT PFD STOCK PP            | CUSIP: TC0KH48I6<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1867734 | NS      | $12186217.26   | 0.11%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | DELFI DIAGNOSTICS SR A CVT PFD STOCK PP            | CUSIP: TC0LOSSE0<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   3426868 | NS      | $16605094.51   | 0.15%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | FOG PHARMA SER E CVT PFD PP                        | CUSIP: TC0O5RRO6<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    623217 | NS      | $3881457.80    | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | TREELINE BIO SER A CVT PFD STOCK PP                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   2370150 | NS      | $20407702.55   | 0.18%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | GALVANIZE THERA CVT PROM NOTE 12/24 PP             | CUSIP: 000000000<br>LEI: N/A                  | Long             | DBT              | CORP              | US        |   4405600 | PA      | $7122533.52    | 0.06%             | 2027-02-28      | None          | 0.00%                 | Yes           |                  3 | On Loan: No      |
| N/A                                   | Ginkgo Bioworks Holdings Earn Out Shares $15.00 PP | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5317 | NS      | $0.00          | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | CAPSULE CORP SERIES E CVT PFD STOCK PP             | CUSIP: TC0YJ3TD4<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    906656 | NS      | $1169586.24    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | EIKON THERAPEUTICS SER C CVT PFD STK PP            | CUSIP: TC0ZK0Q06<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    157292 | NS      | $919284.91     | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | CELLANOME SERIES A CVT PFD STOCK PP                | CUSIP: TC13MXKE8<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1993387 | NS      | $14930468.63   | 0.13%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | ELEMENT BIOSCIENCES SER D-1 CVT PFD PP             | CUSIP: TC141T8S1<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    281354 | NS      | $2206743.83    | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | LARONDE SERIES B CVT PFD STOCK PP                  | CUSIP: TC14DLDG5<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1169887 | NS      | $1684637.28    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | INSITRO SER B CVT PFD PP                           | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    883580 | NS      | $16161650.14   | 0.14%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Freenome Inc                          | FREENOME HOLDINGS SER F CVT PFD PP                 | CUSIP: TC17ZDYA2<br>LEI: 254900QDTSQ6S0QOCS43 | Long             | EP               | CORP              | US        |    178707 | NS      | $877451.37     | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | CLEERLY SER C CVT PFD STK PP                       | CUSIP: TC1A1CZJ4<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    586029 | NS      | $6903421.62    | 0.06%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | COLOR HEALTH SER D CVT PFD STOCK PP                | CUSIP: TC1HL9RU8<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    296922 | NS      | $5697933.18    | 0.05%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | KARTOS THERAPEUTICS SR C CVT PFD STK PP            | CUSIP: TC1HQTAC7<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1873841 | NS      | $10592823.17   | 0.09%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | ENDEAVOR BIO SER C CVT PFD PP                      | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    489761 | NS      | $3195494.62    | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | NATIONAL RESILIENCE SER B CVT PFD STOCK            | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1204832 | NS      | $19361650.24   | 0.17%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | NATIONAL RESILIENCE SER C CVT PFD STOCK            | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    426855 | NS      | $6859559.85    | 0.06%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | Ginkgo Bioworks Holdings Earn Out Shares $17.50 PP | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5317 | NS      | $0.00          | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | PROGNOMIQ INC PP                                   | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    606647 | NS      | $368416.72     | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | PROFOUNDBIO EXPENSE FUND PYMT                      | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |      2348 | NS      | $469.66        | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | GENESIS THERA SEV B CVT PFD STOCK PP               | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1987585 | NS      | $10151789.15   | 0.09%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | ODYSSEY THERAPEUTICS WARRANTS 6/32 WRT PP          | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    133346 | NS      | $0.00          | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | KARDIUM INC SER D-5 CVT PFD STOCK PP               | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   8849057 | NS      | $7249147.49    | 0.06%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | AFFINIVAX AFX3772 MILESTONE EVENT PP               | CUSIP: TC2HD0ET2<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   7349672 | NS      | $5438757.29    | 0.05%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Gyroscope Therapeutics Ltd            | GYROSCOPE THERAPEUTICS MILESTONE PAYMENT 2 PP      | CUSIP: 000000000<br>LEI: 21380066POJ2YSHZAD73 | Long             | EC               | CORP              | US        |   3788007 | NS      | $0.00          | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | HONOR TECHNOLOGY SER E CVT PFD STOCK PP            | CUSIP: TC2V4FT13<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   2095807 | NS      | $2808381.38    | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | FOG PHARMA SER D CVT PFD STOCK PP                  | CUSIP: TC2VY7UZ1<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    615203 | NS      | $4517189.55    | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| REFLEXION MEDICAL INC                 | REFLEXION MEDICAL INC CVT PFD SR C PP              | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   2507885 | NS      | $4313562.20    | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Caris Life Sciences Inc               | Caris Life Sciences, Inc. IPO                      | CUSIP: 000000000<br>LEI: 549300LX5LO78M5VPY43 | Long             | EC               | CORP              | US        |   1916953 | NS      | $51220984.19   | 0.45%             |  |  |  | Yes           |                  2 | On Loan: No      |
| N/A                                   | CLEAR LABS SERIES C CVT PFD PP                     | CUSIP: TC385IBS6<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   3830773 | NS      | $12119799.62   | 0.11%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | EIKON THERAPEUTICS SER C-1 CVT PFD STK PP          | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    150661 | NS      | $880530.38     | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Freenome Inc                          | FREENOME HOLDINGS SER B CVT PFD PP                 | CUSIP: 000000000<br>LEI: 254900QDTSQ6S0QOCS43 | Long             | EP               | CORP              | US        |   1558570 | NS      | $7262936.20    | 0.06%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | INSITRO SER C CVT PFD PP                           | CUSIP: TC3HHHWL7<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    588382 | NS      | $10762154.00   | 0.10%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | GENERATE BIOMEDICINES INC SER C CVT PFD            | CUSIP: TC3JNBFQ7<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    372360 | NS      | $4412466.00    | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | COLOR HEALTH SERIES D-1 CVT PFD STOCK PP           | CUSIP: TC3KSMZE0<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    438696 | NS      | $5913622.08    | 0.05%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | CHROMA MEDICINE SER I CVT PFD STOCK PP             | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   7683800 | NS      | $7683800.00    | 0.07%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | ELEMENT BIOSCIENCES SER D CVT PFD PP               | CUSIP: TC3OATBR3<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    281354 | NS      | $2206743.83    | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | SCRIBE THERA SER B CVT PFD STOCK PP                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1027755 | NS      | $6219253.83    | 0.06%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | BLUEJAY THERAPEUTICS SER C CVT PFD PP              | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   2529000 | NS      | $16505771.40   | 0.15%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | NUTCRACKER THERA SER C CVT PFD STOCK PP            | CUSIP: TC3WVBUQ2<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1027785 | NS      | $11050024.87   | 0.10%             |  |  |  | Yes           |                  3 | On Loan: No      |
| DNA Script SAS                        | DNA SCRIPT SERIES C CVT PFD STOCK PP               | CUSIP: TC3XW4UW2<br>LEI: 8945001SCRZOZAUEFH64 | Long             | EP               | CORP              | FR        |     25201 | NS      | $3525452.11    | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | CHROMACODE INC PP                                  | CUSIP: TC43UPY99<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       626 | NS      | $3029.71       | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | SALUDA MEDICAL SERIES D CVT PFD STOCK PP           | CUSIP: TC460A8T3<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    690617 | NS      | $7348164.88    | 0.07%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | SALIOGEN THERA SERIES B CVT PFD STOCK PP           | CUSIP: TC46G6E19<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    104129 | NS      | $0.00          | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | ODYSSEY THERAPEUTICS SR B CVT PFD STK PP           | CUSIP: TC4CBMMO7<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1115915 | NS      | $1763145.70    | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | RING THERAPEUTICS INC PP                           | CUSIP: TC4CR9CB8<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    291704 | NS      | $1341838.40    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | SALUDA MEDICAL WTS 1/23 PP                         | CUSIP: TC4G9B837<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    103592 | NS      | $204076.24     | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | LUMICKS TECH SER D CVT PFD STOCK PP                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |      4954 | NS      | $2670106.92    | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | COLOR HEALTH SERIES E CVT PFD STOCK PP             | CUSIP: TC4SC4HB5<br>LEI: N/A                  | Long             | EP               | CORP              | US        |     44149 | NS      | $1810109.00    | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Verily Life Sciences LLC              | VERILY LIFE SCIENCES LLC SER B UNITS PP            | CUSIP: 000000000<br>LEI: 5493003ZYK1Z7M670M44 | Long             | EC               | CORP              | US        |    113564 | NS      | $3747612.00    | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | FOG PHARMACEUTICALS SERIES C CVT PFD STOCK PP      | CUSIP: TC4W1BVL4<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    431391 | NS      | $3661689.95    | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Exact Sciences Corp                   | - EXACT SCIENCES CMO MILESTONE PP                  | CUSIP: 000000000<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |   3726272 | NS      | $2310288.45    | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | TREELINE BIO SER A-1 CVT PFD STOCK PP              | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   2744291 | NS      | $23629168.80   | 0.21%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Freenome Inc                          | FREENOME HOLDINGS SER D CVT PFD PP                 | CUSIP: 000000000<br>LEI: 254900QDTSQ6S0QOCS43 | Long             | EP               | CORP              | US        |    526504 | NS      | $2600929.76    | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | REFLEXION MEDICAL INC PP                           | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1794104 | NS      | $2368217.28    | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | METSERA INC IPO Common Stock lockup                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1118110 | NS      | $31810229.50   | 0.28%             |  |  |  | Yes           |                  2 | On Loan: No      |
| N/A                                   | GENERATE BIO SER B CVT PFD STOCK PP                | CUSIP: TC5CQ34B0<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1864632 | NS      | $22095889.20   | 0.20%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Tenax Therapeutics Inc                | TENAX THERAPEUTICS PRE FUNDED WTS PP               | CUSIP: 000000000<br>LEI: 549300J03O6B1IJ2B606 | Long             | EC               | CORP              | US        |   2095785 | NS      | $11453800.35   | 0.10%             |  |  |  | Yes           |                  2 | On Loan: No      |
| N/A                                   | CLEAR LABS SER D CVT PFD STOCK PP                  | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    379601 | NS      | $1183026.52    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | GALVANIZE THERAPEUTICS CVT PROM NOTE PP            | CUSIP: 000000000<br>LEI: N/A                  | Long             | DBT              | CORP              | US        |   6172900 | PA      | $10768006.76   | 0.10%             | 2027-02-28      | None          | 0.00%                 | Yes           |                  3 | On Loan: No      |
| N/A                                   | THIRD ARC BIO SER A CVT PFD PP                     | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   4194043 | NS      | $8825105.28    | 0.08%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | ARSENAL BIOSCIENCES SER C CVT PFD PP               | CUSIP: TC5YX3EI8<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    724394 | NS      | $13459240.52   | 0.12%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | Ginkgo Bioworks Holdings Earn Out Shares $20.00 PP | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5317 | NS      | $0.00          | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | SALUDA MEDICAL INC SERIES E CVT PFD PP             | CUSIP: TC68T3TI3<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    266476 | NS      | $2576822.92    | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | TESSERA THERAPEUTICS SER D CVT PFD PP              | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    381989 | NS      | $1978703.02    | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | AVALYN PHARMA SER C-1 CVT PFD STOCK PP             | CUSIP: TC6KYIDL7<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   8436161 | NS      | $6717715.00    | 0.06%             |  |  |  | Yes           |                  3 | On Loan: No      |
| CAPSULE CORP SERIES 1-D CVT PFD STOCK | CAPSULE CORP SERIES 1-D CVT PFD STOCK              | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    853213 | NS      | $1100644.77    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| PAX Labs Inc                          | PAX LABS CLASS A COMMON PP                         | CUSIP: 000000000<br>LEI: 549300FKJA0AEKUHVG68 | Long             | EC               | CORP              | US        |   8397988 | NS      | $2603376.28    | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | SEAPORT THERAPEUTICS SER B CVT PFD PP              | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   2322209 | NS      | $11030492.75   | 0.10%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Gyroscope Therapeutics Ltd            | GYROSCOPE THERAPEUTICS MILESTONE PAYMENT 3 PP      | CUSIP: 000000000<br>LEI: 21380066POJ2YSHZAD73 | Long             | EC               | CORP              | US        |   3788007 | NS      | $0.00          | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | BLUEJAY THERAPEUTICS SER C-1 CVT PFD PP            | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    173971 | NS      | $1135439.13    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | SALUDA MEDICAL INC SERIES E-1 CVT PFD PP           | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    272710 | NS      | $2637105.70    | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | REFLEXION MEDICAL INC CVT                          | CUSIP: TC70GKL85<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1123437 | NS      | $1966014.75    | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | AFFINIVAX NEXT GEN PROD MILESTON EVNT PP           | CUSIP: TC7BEY6E7<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   7349672 | NS      | $2719378.65    | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | CHROMACODE INC SER AA CVT PFD STK PP               | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |     36845 | NS      | $178322.43     | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | Tessera Therapeutics, Inc. Series C                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    674174 | NS      | $3492221.32    | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | Kardium, Inc. Series D-7 CVT Pfd Stock             | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |  12050573 | NS      | $7799612.87    | 0.07%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | Manus Bio, Inc Series One-6                        | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1223104 | NS      | $3669312.00    | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Gyroscope Therapeutics Ltd            | GYROSCOPE THERAPEUTICS MILESTONE PAYMENT 1 PP      | CUSIP: 000000000<br>LEI: 21380066POJ2YSHZAD73 | Long             | EC               | CORP              | US        |   5683928 | NS      | $0.00          | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | PROFOUNBIO ESCROW FUND PAYMENT                     | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    704486 | NS      | $669261.67     | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | DELFI DIAGNOSTICS SR B CVT PFD STOCK PP            | CUSIP: TC7ZV25B2<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1853138 | NS      | $8979491.37    | 0.08%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Exact Sciences Corp                   | EXACT SCIENCES FDA MILESTONE PP                    | CUSIP: 000000000<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |   1863136 | NS      | $1155144.23    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | KARTOS THERAPEUTICS SR D CVT PFD STK PP            | CUSIP: TC82Z0AE2<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    513724 | NS      | $2904081.77    | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Freenome Inc                          | FREENOME HOLDINGS SER C CVT PFD PP                 | CUSIP: TC87S2BF1<br>LEI: 254900QDTSQ6S0QOCS43 | Long             | EP               | CORP              | US        |    928231 | NS      | $4492638.04    | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | ARBOR BIO SERIES B CVT PFD STOCK PP                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    532759 | NS      | $2189639.49    | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | EIKON THERAPEUTICS SER D CVT PFD STK PP            | CUSIP: TC8MOJAD1<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    924929 | NS      | $5405699.44    | 0.05%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | AVALYN PHARMA SER D CVT PFD STOCK PP               | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1666360 | NS      | $1326922.47    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | ODYSSEY THERAPEUTICS SER D CVT PFD STK PP          | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    444487 | NS      | $668939.60     | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | AFFINIVAX EXPENSE FUND PP                          | CUSIP: TC929D1E2<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     12445 | NS      | $11823.17      | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Tenax Therapeutics Inc                | Tenax Therapeutics, Inc                            | CUSIP: 000000000<br>LEI: 549300J03O6B1IJ2B606 | Long             | EC               | CORP              | US        |   1103045 | NS      | $946280.24     | 0.01%             |  |  |  | Yes           |                  2 | On Loan: No      |
| Crescent Biopharma Inc                | Crescent BioPharma, Inc.                           | CUSIP: 000000000<br>LEI: 549300TZ84FFU2J2J459 | Long             | EC               | CORP              | US        |    360441 | NS      | $5526634.36    | 0.05%             |  |  |  | Yes           |                  2 | On Loan: No      |
| N/A                                   | REFLEXION MEDICAL INC SR E CVT PFD PP              | CUSIP: TC9L8ZXJ6<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1857286 | NS      | $3343114.80    | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | HONOR TECHNOLOGY SER D CVT PFD PP                  | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   3130941 | NS      | $4195460.94    | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | ARBOR BIO SERIES C CVT PFD STOCK PP                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    322096 | NS      | $1323814.56    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | EIKON THERA SERIES B CVT PFD STOCK PP              | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    762996 | NS      | $4459290.45    | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | SALUDA MEDICAL CVT PROM NOTE PP                    | CUSIP: 000000000<br>LEI: N/A                  | Long             | DBT              | CORP              | US        |   2201800 | PA      | $2201800.00    | 0.02%             | 2026-12-31      | None          | 0.00%                 | Yes           |                  3 | On Loan: No      |
| N/A                                   | ELEMENT BIOSCIENCES SER C CVT PFD STOCK            | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    861217 | NS      | $8344676.00    | 0.07%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                   | KARDIUM INC SERIES D-8 CVT PFD STOCK PP            | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | CA        |   6786958 | NS      | $4392790.70    | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |

### Signature

**Date Signed:** 2025-08-04

**Name of Applicant:** T. ROWE PRICE HEALTH SCIENCES FUND, INC.

**Signature:** /s/ Alan Dupski

**Name of Signer:** Alan Dupski

**Title:** Treasurer & Vice President