# EDGAR Filing Document

**Accession Number:** 0001746473
**File Stem:** 0001746473-25-000184
**Filing Date:** 2025-12
**Character Count:** 10842
**Document Hash:** ae5c1f73db86758c5d1b056436b7502d
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001746473-25-000184.hdr.sgml**: 20251222

**ACCESSION NUMBER**: 0001746473-25-000184

**CONFORMED SUBMISSION TYPE**: 3

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20251210

**FILED AS OF DATE**: 20251222

**DATE AS OF CHANGE**: 20251222

**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Kuo Minnie
- **CENTRAL INDEX KEY:** 0002101360

**ORGANIZATION NAME:**

**FILING VALUES:**
- **FORM TYPE:** 3
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-39303
- **FILM NUMBER:** 251593266

**MAIL ADDRESS:**
- **STREET 1:** C/O PLIANT THERAPEUTICS, INC.
- **STREET 2:** 331 OYSTER POINT BOULEVARD
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080
**ISSUER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** PLIANT THERAPEUTICS, INC.
- **CENTRAL INDEX KEY:** 0001746473
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 474272481
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**BUSINESS ADDRESS:**
- **STREET 1:** 331 OYSTER POINT BOULEVARD
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080
- **BUSINESS PHONE:** 650-481-6770

**MAIL ADDRESS:**
- **STREET 1:** 331 OYSTER POINT BOULEVARD
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080

## Ex-24

```

LIMITED POWER OF ATTORNEY

	The undersigned hereby constitutes and appoints each of
Keith Cummings, Jennifer Woo and Scott Peters of Pliant Therapeutics, Inc.
(the "Company"), signing singly, and with full power of substitution,
the undersigned's true and lawful attorney-in-fact to:

	(1)	take actions as may be necessary or appropriate to enable
the undersigned to submit and file forms, schedules and other documents
with the U.S. Securities and Exchange Commission (the "SEC") utilizing
the SEC's Electronic Data Gathering and Retrieval ("EDGAR") system, which
actions may include (a) enrolling the undersigned in EDGAR Next and
(b) preparing, executing and submitting to the SEC a Form ID, amendments
thereto, and such other documents and information as may be necessary
or appropriate to obtain codes and passwords enabling the undersigned
to make filings and submissions utilizing the EDGAR system;

	(2) 	execute for and on behalf of the undersigned, in the undersigned's
capacity as an officer of Company, from time to time the following
SEC forms: (i) Form 3, Initial Statement of Beneficial Ownership of Securities,
including any attached documents; (ii) Form 4, Statement of Changes
in Beneficial Ownership of Securities, including any attached documents;
(iii) Form 5, Annual Statement of Beneficial Ownership of Securities
in accordance with Section 16(a) of the Securities Exchange Act of 1934,
as amended, and the rules thereunder, including any attached documents;
(v) Schedules 13D and 13G; and (vi) amendments of each thereof, in accordance
with the Securities Exchange Act of 1934, as amended, and the rules thereunder,
including any attached documents;

	(3)	do and perform any and all acts for and on behalf of the undersigned
which may be necessary or desirable to complete and execute any such
Form 3, 4 or 5, Schedule 13D or 13G, or any amendment(s) thereto
and timely file such form(s) with the SEC and any securities exchange,
national association or similar authority;

	(4) 	act as account administrator for the undersigned's EDGAR account,
including: (i) appointing, removing and replacing account administrators,
account users, technical administrators and delegated entities;
(ii) maintaining the security of the undersigned EDGAR account, including
modifications of access codes; (iii) maintaining, modifying and certifying
the accuracy of information of the undersigned's EDGAR account dashboard;
(iv) acting as the EDGAR point of contact with respect to the undersigned's
EDGAR account; and (v) any actions contemplated by Rule 10 of
Regulation S-T with respect to account administrators;

	(5)	cause the Company to accept delegation of authority from any of
the undersigned's EDGAR account administrators and, pursuant to that
delegation, authorize the Company's EDGAR account administrators to appoint,
remove or replace users for the undersigned's EDGAR account; and

	(6)	take any other action of any type whatsoever in connection with the
foregoing which, in the opinion of such attorney-in-fact, may be of benefit to,
in the best interest of, or legally required by, the undersigned, it being
understood that the documents executed by such attorney-in-fact
on behalf of the undersigned pursuant to this Power of Attorney
shall be in such form and shall contain such terms and conditions as such
attorney-in-fact may approve in such attorney-in-fact's discretion.

	The undersigned hereby grants to each such attorney-in-fact, acting singly,
full power and authority to do and perform any and every act and thing
whatsoever requisite, necessary or proper to be done in the exercise of any of
the rights and powers herein granted, as fully to all intents and
purposes as the undersigned might or could do if personally present,
with full power of substitution or revocation, hereby ratifying and confirming
all that such attorney-in-fact, or such attorney-in-fact's substitute or
substitutes, shall lawfully do or cause to be done by virtue of this
power of attorney and the rights and powers herein granted.
The undersigned acknowledges that the foregoing attorneys-in-fact,
in serving in such capacity at the request of the undersigned, are not
assuming, nor is the Company assuming, any of the undersigned's
responsibilities to comply with Section 16 or Regulation 13D-G of the
Securities Exchange Act of 1934, as amended.  The undersigned hereby agrees
to indemnify the attorneys-in-fact and the Company from and against
any demand, damage, loss, cost or expense arising from any false or misleading
information provided by the undersigned to the attorneys-in-fact.

	This Power of Attorney shall remain in full force and effect until
the undersigned is no longer required to file such forms with respect to
the undersigned's holdings of and transactions in securities issued by
the Company, unless earlier revoked by the undersigned in a signed writing
delivered to the foregoing attorneys-in-fact.  This Power of Attorney
supersedes any prior power of attorney in connection with the undersigned's
capacity as an officer and/or director of the Company.  This Power of Attorney
shall expire as to any individual attorney-in-fact if such attorney-in-fact
ceases to be an employee of, or legal counsel to, the Company.

	IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be
executed as of 03 December 2025.

							/s/ Minnie Kuo
							Signature

							Minnie Kuo
							Print Name

```

### UNITED STATES SECURITIES AND EXCHANGE COMMISSION
**Washington, D.C. 20549**

## FORM 3

### INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Kuo Minnie<br><sub>(Last) (First) (Middle)</sub><br>C/O PLIANT THERAPEUTICS, INC.<br>331 OYSTER POINT BOULEVARD<br><sub>(Street)</sub><br>SOUTH SAN FRANCISCO, CA 94080<br><sub>(City) (State) (Zip)</sub> | **3. Issuer Name and Ticker or Trading Symbol**<br>PLIANT THERAPEUTICS, INC. [ PLRX ] | **5. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  |
| **2. Date of Event Requiring Statement (Month/Day/Year)**<br>2025-12-10 | **4. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[ ] Director   [ ] 10% Owner<br>[X] Officer (give title below)   [ ] Other (specify below)<br>_Chief Operating Officer_ | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[X] Form filed by One Reporting Person<br>[ ] Form filed by More than One Reporting Person |

---

## Table I - Non-Derivative Securities Beneficially Owned

---

|  |  |  |  |
| --- | --- | --- | --- |
| 1. Title of Security | 2. Amount of Securities Beneficially Owned | 3. Ownership Form | 4. Nature of Indirect Beneficial Ownership |
| Common Stock | 44723 | D |  |

---

## Table II - Derivative Securities Beneficially Owned

---

|  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- |
| 1. Title of Derivative Security | 2. Date Exercisable and Expiration Date (Month/Day/Year) | 2. Date Exercisable and Expiration Date (Month/Day/Year) | 3. Title and Amount of Underlying Securities | 3. Title and Amount of Underlying Securities | 4. Conversion or Exercise Price | 5. Ownership Form | 6. Nature of Indirect Beneficial Ownership |
| 1. Title of Derivative Security | Date Exercisable | Expiration Date | Title | Amount or Number of Shares | 4. Conversion or Exercise Price | 5. Ownership Form | 6. Nature of Indirect Beneficial Ownership |
| Stock Option (Right to Buy) | <sup>(1)</sup> | 2033-09-14 | Common Stock | 150000 | $16.18 | D |  |
| Stock Option (Right to Buy) | <sup>(2)</sup> | 2034-01-23 | Common Stock | 40000 | $17.44 | D |  |
| Stock Option (Right to Buy) | <sup>(3)</sup> | 2035-01-23 | Common Stock | 55200 | $11.14 | D |  |

---

### Footnotes:

(1) 25% of the shares subject to such option vest on September 14, 2024 and 1/48th of the shares subject to the option vest in substantially equal monthly installments thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date.

(2) 1/48th of the shares subject to such option vest and become exercisable in substantially equal installments on each such monthly anniversary of January 1, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date.

(3) 1/48th of the shares subject to such option vest and become exercisable in substantially equal installments on each monthly anniversary of January 1, 2025, subject to the Reporting Person's continuous service to the Issuer on each such date.

**Remarks:**
Exhibit List: Exhibit 24 Power of Attorney

**Signature:** /s/ Jennifer Woo, attorney-in-fact  
**Date:** 2025-12-22

### Remarks:

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

**Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.**