# EDGAR Filing Document

**Accession Number:** 0001029125
**File Stem:** 0001437749-23-006896
**Filing Date:** 2023-3
**Character Count:** 24810
**Document Hash:** 77013e11800190f74b444520147d5799
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001437749-23-006896.hdr.sgml**: 20230316

**ACCESSION NUMBER**: 0001437749-23-006896

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 15

**CONFORMED PERIOD OF REPORT**: 20230316

**ITEM INFORMATION**: Results of Operations and Financial Condition

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20230316

**DATE AS OF CHANGE**: 20230316

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Panbela Therapeutics, Inc.
- **CENTRAL INDEX KEY:** 0001029125
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 870543922
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-39468
- **FILM NUMBER:** 23738886

**BUSINESS ADDRESS:**
- **STREET 1:** 712 VISTA BLVD #305
- **CITY:** WACONIA
- **STATE:** MN
- **ZIP:** 55387
- **BUSINESS PHONE:** 9524791196

**MAIL ADDRESS:**
- **STREET 1:** 712 VISTA BLVD #305
- **CITY:** WACONIA
- **STATE:** MN
- **ZIP:** 55387

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Sun BioPharma, Inc.
- **DATE OF NAME CHANGE:** 20150911

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Cimarron Medical, Inc.
- **DATE OF NAME CHANGE:** 20150602

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** CIMARRON SOFTWARE INC
- **DATE OF NAME CHANGE:** 19961217

pbla20230315_8k.htm

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

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**FORM **8-K**

**CURRENT REPORT**

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

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| |
|:---|
| **March 16, 2023** |
| Date of Report (Date of Earliest Event Reported) |

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| |
|:---|
| **Panbela Therapeutics, Inc** |
| (Exact Name of Registrant as Specified in its Charter) |

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| | | |
|:---|:---|:---|
| **Delaware** | **001-39468** | **88-2805017** |
| (State of Incorporation) | (Commission File Number) | (I.R.S. Employer Identification No.) |

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| | |
|:---|:---|
| **712 Vista Blvd #305**<br> **Waconia**, **Minnesota** | **55387** |
| (Address of Principal Executive Offices) | (Zip Code) |

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| |
|:---|
| **(**952**) **479-1196** |
| (Registrant's Telephone Number, Including Area Code) |

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(Former Name or Former Address, if Changed Since Last Report.)<br>

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

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| | | |
|:---|:---|:---|
| **Title of each class** | **Trading Symbol** | **Name of each exchange on which registered** |
| Common Stock, $0.001 par value | PBLA | The Nasdaq Stock Market LLC |

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Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 or Rule 12b-2 of the Securities Exchange Act of 1934.

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

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| | |
|:---|:---|
| **Item 2.02.** | **Results of Operations and Financial Condition.** |

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On March 16, 2023, Panbela Therapeutics, Inc. (the "Company") issued a press release providing a business update and announcing financial results for the fiscal year ended December 31, 2022. The full text of the press release is set forth in Exhibit 99.1 attached hereto and is incorporated by reference in this current report on Form 8-K as if fully set forth herein.

The Company is furnishing the information contained in this report, including Exhibit 99.1, pursuant to Item 2.02 of Form 8-K promulgated by the Securities and Exchange Commission (the "SEC"). This information shall not be deemed to be "filed" with the SEC for the purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liabilities of that section, nor shall it be deemed to be incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such filing.

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| | |
|:---|:---|
| **Item 9.01.** | **Financial Statements and Exhibits.** |

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(d) *Exhibits*

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| | | |
|:---|:---|:---|
| **Exhibit No.** | **Description** | **Method of Filing** |
| 99.1 | [Press release dated March 16, 2023](ex_489485.htm) | Furnished Herewith |
| 104 | Cover Page Interactive Data File (embedded in the cover page formatted as Inline XBRL) |  |

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.**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this Current Report to be signed on its behalf by the undersigned hereunto duly authorized.

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| | | |
|:---|:---|:---|
|  | PANBELA THERAPEUTICS, INC. | PANBELA THERAPEUTICS, INC. |
| Date: March 16, 2023  | By:  | /s/ Susan Horvath |
|  |  | Susan Horvath |
|  |  | Chief Financial Officer |

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## Exhibit 99.1

**Exhibit 99.1**

![ex_489485img001.jpg](ex_489485img001.jpg)

**Panbela Provides Business Update and Reports Q4 and FY 2022 Financial Results**

**MINNEAPOLIS -- Panbela Therapeutics, Inc.** (Nasdaq: PBLA), a clinical stage company developing disruptive therapeutics for the treatment of patients with urgent unmet medical needs, today provides a business update and reports financial results for the quarter and full year ended December 31, 2022. As previously announced, management is hosting earnings call today at 4:30 p.m. ET.

2022 and early 2023 Highlights:

● Significant progress was made on the conduct of the ASPIRE global clinical trial studying ivospemin (SBP-101) in combination with gemcitabine and nab-paclitaxel in the first-line treatment of metastatic pancreatic ductal adenocarcinoma:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Initiated ASPIRE trial in January 2022

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Received approval from the Australian Human Research Ethics Committee (HREC) to expand the ASPIRE global clinical trial to Australia

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Enrolled first patient in South Korea

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Enrolled first patient in Europe

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Enrolled first patient in Australia

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Received approvals to open trial sites in Spain, France and Italy

● An abstract for ivospemin will be presented at the American Association for Cancer Research (AACR), which will be held April 14-19, 2023. The work reflects the Company's on-going collaboration with Johns Hopkins University School of Medicine

● Closed a registered public offering yielding gross proceeds of approximately $15 million in Q1 of 2023

● Started Phase II Trial of CPP-1X-T for Recent Onset Type I Diabetes in January 2023, in collaboration with Indiana University and the Juvenile Diabetes Research Foundation

● European Medicines Agency (EMA) Committee for Orphan Medicinal Products issued the Adoption of Commission Implementing Decision relating to the designation of ivospemin as an orphan medicinal product in March 2023

● Closed a registered public offering yielding gross proceeds of approximately $6.0 million in Q4 of 2022

● Hosted an R&D call joined by leading experts for a deep dive on the company's investigational drug, ivospemin, as a polyamine metabolism modulator in ovarian cancer

● Completed the acquisition of Cancer Prevention Pharmaceuticals, Inc. (CPP)

● Presented a poster highlighting the results for ivospemin as a polyamine metabolism modulator in ovarian cancer at the American Association for Cancer Research (AACR) in April 2022

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● Presented a poster highlighting the Clinical Data on Phase 1b Clinical Trial of ivospemin in Combination with Gemcitabine and Nab-Paclitaxel in Patients with Metastatic PDA at 2022 ASCO GI Meeting

"During Q4 and year to date, we progressed our pipeline, which has been principally funded through collaborations," said Jennifer K. Simpson, PhD, MSN, CRNP, President & Chief Executive Officer of Panbela. "Milestones achieved included first patients enrolled in Australia, Europe and South Korea in our ASPIRE global trial for metastatic pancreatic cancer, and EMA Orphan drug designation. Additionally, we bolstered our balance sheet with gross proceeds from recent public offerings. As we move forward in 2023, we anticipate a consistent stream of milestones to drive shareholder value."

**Fourth Quarter ended December 31, 2022 Financial Results**

General and administrative expenses were $1.7 million in the fourth quarter of 2022, compared to $1.3 million in the fourth quarter of 2021. The increase primarily is due to severance expenses associated with the acquisition of CPP.

Research and development expenses were $3.5 million in the fourth quarter of 2022, compared to $2.0 million in the fourth quarter of 2021. The change is due primarily to an increase in spending on our clinical studies as we expanded the ASPIRE clinical trial.

Net loss in the fourth quarter of 2022 was $4.7 million, or $5.68 per diluted share, compared to a net loss of $3.5 million, or $10.54 per diluted share, in the fourth quarter of 2021. All share and per-share amounts have been restated to reflect the 40-for-1 reverse split of our common stock, which was effective on January 13, 2023.

Total cash was $1.3 million as of December 31, 2022. Total current assets were $1.8 million and current liabilities were $7.8 million as of the same date. Notes payable, plus accrued interest, on the balance sheet, the result of the acquisition of CPP, totaled approximately $7.2 million. The current portion of the notes payable plus accrued interest totaled approximately $2.0 million.

Subsequent to the end of the year, the Company completed a registered public offering. Gross proceeds from the raise, which closed on January 30, 2023, were approximately $15 million.

**Conference Call Information**

Toll Free: 888-506-0062<br> International: 973-528-0011<br> Participant Access Code: 116790<br> Webcast Link: <u>**https://www.webcaster4.com/Webcast/Page/2556/47782**</u>

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**Conference Call Replay Information**

Toll Free: 877-481-4010<br> International: 919-882-2331<br> Replay Passcode: 47782<br> Webcast Replay: <u>**https://www.webcaster4.com/Webcast/Page/2556/47782**</u>

**About Panbela**'**s Pipeline**

The pipeline consists of assets currently in clinical trials with an initial focus on familial adenomatous polyposis (FAP), first-line metastatic pancreatic cancer, neoadjuvant pancreatic cancer, colorectal cancer prevention and ovarian cancer. The combined development programs have a steady cadence of catalysts with programs ranging from pre-clinical to registration studies.

***Ivospemin (SBP-101)***

Ivospemin is a proprietary polyamine analogue designed to induce polyamine metabolic inhibition (PMI) by exploiting an observed high affinity of the compound for pancreatic ductal adenocarcinoma and other tumors. It has shown signals of tumor growth inhibition in clinical studies of metastatic pancreatic cancer patients, demonstrating a median overall survival (OS) of 14.6 months and an objective response rate (ORR) of 48%, both exceeding what is typical for the standard of care of gemcitabine + nab-paclitaxel suggesting potential complementary activity with the existing FDA-approved standard chemotherapy regimen. In data evaluated from clinical studies to date, ivospemin has not shown exacerbation of bone marrow suppression and peripheral neuropathy, which can be chemotherapy-related adverse events. Serious visual adverse events have been evaluated and patients with a history of retinopathy or at risk of retinal detachment will be excluded from future SBP-101 studies. The safety data and PMI profile observed in the previous Panbela-sponsored clinical trials provide support for continued evaluation of ivospemin in the ASPIRE trial.

***Flynpovi***™

Flynpovi is a combination of CPP-1X (eflornithine) and sulindac with a dual mechanism inhibiting polyamine synthesis and increasing polyamine export and catabolism. In a Phase 3 clinical trial in patients with sporadic large bowel polyps, the combination prevented > 90% subsequent pre-cancerous sporadic adenomas versus placebo. Focusing on FAP patients with lower gastrointestinal tract anatomy in the recent Phase 3 trial comparing Flynpovi to single agent eflornithine and single agent sulindac, FAP patients with lower GI anatomy (patients with an intact colon, retained rectum or surgical pouch), showed statistically significant benefit compared to both single agents (p≤0.02) in delaying surgical events in the lower GI for up to four years. The safety profile for Flynpovi did not significantly differ from the single agents and supports the continued evaluation of Flynpovi for FAP.

***CPP-1X***

CPP-1X (eflornithine) is being developed as a single agent tablet or high dose powder sachet for several indications including prevention of gastric cancer, treatment of neuroblastoma and recent onset Type 1 diabetes. Preclinical studies as well as Phase 1 or Phase 2 investigator-initiated trials suggest that CPP-1X treatment may be well-tolerated and has potential activity.

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**About Panbela**

Panbela Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing disruptive therapeutics for patients with urgent unmet medical needs. Panbela's lead assets are Ivospemin (SBP-101) and Flynpovi. Further information can be found at <u>**www.panbela.com**</u>**.** Panbela's common stock is listed on The Nasdaq Stock Market LLC under the symbol "PBLA".

**Cautionary Statement Regarding Forward-Looking Statements**

*This press release contains* "*forward-looking statements,*" *including within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by words such as:* "*aim,*" "*anticipate,*" "*believe,*" "*design,*" "*expect,*" "*feel,*" "*focus,*" "*intend,*" "*may,*" "*plan,*" "*potential,*" "*scheduled,*" *and* "*will.*" *All statements other than statements of historical fact are statements that should be deemed forward-looking statements. Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based only on our current beliefs, expectations, and assumptions regarding the future of our business, future plans and strategies, projections, anticipated events and trends, the economy and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of which are outside of our control. Our actual results and financial condition may differ materially and adversely from the forward-looking statements. Therefore, you should not rely on any of these forward-looking statements. Important factors that could cause our actual results and financial condition to differ materially from those indicated in the forward-looking statements include, among others, the following: (i) our ability to obtain additional funding to execute our business and clinical development plans; (ii) progress and success of our clinical development program; (iii) the impact of the current COVID-19 pandemic on our ability to conduct our clinical trials; (iv) our ability to demonstrate the safety and effectiveness of our product candidates: ivospemin (SBP-101) and eflornithine (CPP-1X); (v) our reliance on a third party for the execution of the registration trial for our product candidate Flynpovi; (vi) our ability to obtain regulatory approvals for our product candidates, SBP-101 and CPP-1X in the United States, the European Union or other international markets; (vii) the market acceptance and level of future sales of our product candidates, SBP-101 and CPP-1X; (viii) the cost and delays in product development that may result from changes in regulatory oversight applicable to our product candidates, SBP-101 and CPP-1X; (ix) the rate of progress in establishing reimbursement arrangements with third-party payors; (x) the effect of competing technological and market developments; (xi) the costs involved in filing and prosecuting patent applications and enforcing or defending patent claims; (xii) our ability to maintain the listing of our common stock on a national securities exchange; and (xiii) such other factors as discussed in Part I, Item 1A under the caption* "*Risk Factors*" *in our most recent Annual Report on Form 10-K, any additional risks presented in our Quarterly Reports on Form 10-Q and our Current Reports on Form 8-K. Any forward-looking statement made by us in this press release is based on information currently available to us and speaks only as of the date on which it is made. We undertake no obligation to publicly update any forward-looking statement or reasons why actual results would differ from those anticipated in any such forward-looking statement, whether written or oral, whether as a result of new information, future developments or otherwise.*

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Contact Information:

Investors:<br> James Carbonara<br> Hayden IR<br> (646) 755-7412<br> <u>**james@haydenir.com**</u>

Media:<br> Tammy Groene<br> Panbela Therapeutics, Inc.<br> (952) 479-1196<br> <u>**IR@panbela.com**</u>

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**Panbela Therapeutics, Inc.**

**Consolidated Statements of Operations and Comprehensive Loss (unaudited)**

(In thousands, except share and per share amounts)

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| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | Three months ended December 31, | Three months ended December 31, | Three months ended December 31, | Year ended December 31, | Year ended December 31, | Year ended December 31, |
|  | 2022 | 2021 | Percent<br> Change | 2022 | 2021 | Percent<br> Change |
| Operating expenses: |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp; General and administrative | $1661 | $1272 | 30.6% | $6044 | $4587 | 31.8% |
| &nbsp;&nbsp;&nbsp; Research and development | 3463 | 2049 | 69.0% | 28049 | 5423 | 417.2% |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Operating loss | (5124) | (3321) | 54.3% | (34093) | (10010) | 240.6% |
| Other income (expense): |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp; Interest income | 3 |  |  | 14 | 1 | 1300.0% |
| &nbsp;&nbsp;&nbsp; Interest expense | (181) | (2) | 8950.0% | (288) | (12) | 2300.0% |
| &nbsp;&nbsp;&nbsp; Other income (expense) | 556 | 3 | 18433.3% | (682) | (602) | 13.3% |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Total other income (expense) | 378 | 1 | 37700.0% | (956) | (613) | 56.0% |
| Loss before income tax benefit | (4746) | (3320) | 43.0% | (35049) | (10623) | 229.9% |
| Income tax benefit | 13 | (218) | -106.0% | 116 | 488 | -76.2% |
| Net loss | (4733) | (3538) | 33.8% | (34933) | (10135) | 244.7% |
| Foreign currency translation adjustment (loss) | (615) | (50) | 1130.0% | 626 | 517 | 21.1% |
| Comprehensive Loss | $(5348) | $(3588) | 49.1% | $(34307) | $(9618) | 256.7% |
| Basic and diluted net loss per share | $(5.68) | $(10.54) | -46.1% | $(67.91) | $(34.64) | 96.0% |
| Weighted average shares outstanding - basic and diluted | 832844 | 335803 | 148.0% | 514369 | 292607 | 75.8% |

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**Panbela Therapeutics, Inc.**

**Consolidated Balance Sheets (unaudited)**

(In thousands, except share amounts)

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| | | |
|:---|:---|:---|
|  | December 31, 2022 | December 31, 2021 |
| **ASSETS** |  |  |
| Current assets: |  |  |
| &nbsp;&nbsp;&nbsp; Cash and cash equivalents | $1285 | $11867 |
| &nbsp;&nbsp;&nbsp; Prepaid expenses and other current assets | 443 | 91 |
| &nbsp;&nbsp;&nbsp; Income tax receivable | 49 | 321 |
| Total current assets | 1777 | 12279 |
| Other noncurrent assets | 3201 | 593 |
| Total assets | $4978 | $12872 |
| **LIABILITIES AND STOCKHOLDERS' (DEFICIT) EQUITY** |  |  |
| Current liabilities: |  |  |
| &nbsp;&nbsp;&nbsp; Accounts payable | $2865 | $640 |
| &nbsp;&nbsp;&nbsp; Accrued expenses | 2993 | 2020 |
| &nbsp;&nbsp;&nbsp; Accrued interest payable | 325 |  |
| &nbsp;&nbsp;&nbsp; Note payable | 650 |  |
| &nbsp;&nbsp;&nbsp; Debt, current portion | 1000 |  |
| Total current liabilities | 7833 | 2660 |
| &nbsp;&nbsp;&nbsp; Debt, net of current portion | 5194 |  |
| Total non current liabilities | 5194 |  |
| Total liabilities | 13027 | 2660 |
| Stockholders' (deficit) equity: |  |  |
| &nbsp;&nbsp;&nbsp; Preferred stock, $0.001 par value; 10,000,000 authorized; no shares issued or outstanding as of December 31, 2022 and December 31, 2021 |  |  |
| &nbsp;&nbsp;&nbsp; Common stock, $0.001 par value; 100,000,000 authorized; 1,049,644 and 335,961 shares issued and outstanding, as of December 31, 2022 and December 31, 2021, respectively | 1 |  |
| &nbsp;&nbsp;&nbsp; Additional paid-in capital | 82285 | 66240 |
| &nbsp;&nbsp;&nbsp; Accumulated deficit | (91094) | (56161) |
| &nbsp;&nbsp;&nbsp; Accumulated comprehensive income | 759 | 133 |
| Total stockholders' (deficit) equity | (8049) | 10212 |
| Total liabilities and stockholders' (deficit) equity | $4978 | $12872 |

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**Panbela Therapeutics, Inc.**

**Consolidated Statements of Cash Flows (unaudited)**

(In thousands)

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| | | |
|:---|:---|:---|
|  | Year Ended December 31, | Year Ended December 31, |
|  | 2022 | 2021 |
| **Cash flows from operating activities:** |  |  |
| Net loss | $(34933) | $(10135) |
| &nbsp;&nbsp;&nbsp; Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Write off of in process research and development (IPR&D) | 17737 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Stock-based compensation | 1088 | 1287 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Non-cash interest expense | 273 |  |
| &nbsp;&nbsp;&nbsp; Changes in operating assets and liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Income tax receivable | 212 | 51 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Prepaid expenses and other current assets | (127) | 247 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Deposits held for clinical trial costs | (2561) | (540) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Accounts payable | 2249 | 631 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Accrued liabilities | 786 | 1214 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Net cash used in operating activities | (15276) | (7245) |
| **Cash flows from investing activities:** |  |  |
| &nbsp;&nbsp;&nbsp; Investment in IPR&D | (660) |  |
| &nbsp;&nbsp;&nbsp; Cash acquired in merger | 4 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Net cash used in investing activities | (656) |  |
| **Cash flows from financing activities:** |  |  |
| &nbsp;&nbsp;&nbsp; Proceeds from sale of common stock,net of fees and offering costs of $44 | 46 |  |
| &nbsp;&nbsp;&nbsp; Proceeds from public offering of common stock and warrants net of underwriters discount and offering costs of $727 | 5303 |  |
| &nbsp;&nbsp;&nbsp; Proceeds from public offering of common stock net of underwriters discount and offering costs of $946 |  | 9054 |
| &nbsp;&nbsp;&nbsp; Proceeds from exercise of warrants | 5 | 1042 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Net cash provided by financing activities | 5354 | 10096 |
| Effect of exchange rate changes on cash | (4) | (6) |
| Net change in cash | (10582) | 2845 |
| Cash and cash equivalents at beginning of year | 11867 | 9022 |
| Cash and cash equivalents at end of year | $1285 | $11867 |
| **Supplemental disclosure of cash flow information:** |  |  |
| &nbsp;&nbsp;&nbsp; Cash paid during period for interest | $15 | $12 |
| **Supplemental disclosure of non-cash transactions:** |  |  |
| &nbsp;&nbsp;&nbsp; Fair value of common stock, stock options and stock warrants issued as consideration for asset acquisition | $9605 | $- |

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