# EDGAR Filing Document

**Accession Number:** 0001503802
**File Stem:** 0001493152-25-020601
**Filing Date:** 2025-11
**Character Count:** 10737
**Document Hash:** 2b6f8094ae3a2939b67a34b3cebcd781
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001493152-25-020601.hdr.sgml**: 20251103

**ACCESSION NUMBER**: 0001493152-25-020601

**CONFORMED SUBMISSION TYPE**: SCHEDULE 13G/A

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20251103

**DATE AS OF CHANGE**: 20251103

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Karyopharm Therapeutics Inc.
- **CENTRAL INDEX KEY:** 0001503802
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 263931704
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SCHEDULE 13G/A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-87705
- **FILM NUMBER:** 251444570

**BUSINESS ADDRESS:**
- **STREET 1:** 85 WELLS AVENUE
- **STREET 2:** SECOND FLOOR
- **CITY:** NEWTON
- **STATE:** MA
- **ZIP:** 02459
- **BUSINESS PHONE:** 617-658-0600

**MAIL ADDRESS:**
- **STREET 1:** 85 WELLS AVENUE
- **STREET 2:** SECOND FLOOR
- **CITY:** NEWTON
- **STATE:** MA
- **ZIP:** 02459
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** J. WOOD CAPITAL ADVISORS LLC
- **CENTRAL INDEX KEY:** 0001586446

**ORGANIZATION NAME:**
- **EIN:** 463547463
- **STATE OF INCORPORATION:** CA
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SCHEDULE 13G/A

**BUSINESS ADDRESS:**
- **STREET 1:** 1820 CALISTOGA ROAD
- **CITY:** SANTA ROSA
- **STATE:** CA
- **ZIP:** 95404
- **BUSINESS PHONE:** 415-577-5305

**MAIL ADDRESS:**
- **STREET 1:** 1820 CALISTOGA ROAD
- **CITY:** SANTA ROSA
- **STATE:** CA
- **ZIP:** 95404

### UNITED STATES SECURITIES AND EXCHANGE COMMISSION
**Washington, D.C. 20549**

## SCHEDULE 13G

### Under the Securities Exchange Act of 1934

**(Amendment No. 1)**

**Issuer:** Karyopharm Therapeutics Inc.

**Title of Class of Securities:** Common Stock, $0.0001 par value

**CUSIP Number:** 48576U205

**Date of Event Which Requires Filing of this Statement:** 10/14/2025

**Check the appropriate box to designate the rule pursuant to which this Schedule is filed:**

- [ ] Rule 13d-1(b)

- [x] Rule 13d-1(c)

- [ ] Rule 13d-1(d)

---

| 1. | Names of Reporting Persons<br>J. Wood Capital Advisors LLC | Names of Reporting Persons<br>J. Wood Capital Advisors LLC |
|:---|:---|:---|:---|
| 2. | Check the Appropriate Box if a Member of a Group (See Instructions)<br>(a) [ ] (b) [ ] | Check the Appropriate Box if a Member of a Group (See Instructions)<br>(a) [ ] (b) [ ] |
| 3. | SEC Use Only | SEC Use Only |
| 4. | Citizenship or Place of Organization<br>CA | Citizenship or Place of Organization<br>CA |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 5. | Sole Voting Power<br>0.00 |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 6. | Shared Voting Power<br>1000708.00 |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 7. | Sole Dispositive Power<br>0.00 |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 8. | Shared Dispositive Power<br>1000708.00 |
| 9. | Aggregate Amount Beneficially Owned by Each Reporting Person<br>1000708.00 | Aggregate Amount Beneficially Owned by Each Reporting Person<br>1000708.00 |
| 10. | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) [ ] | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) [ ] |
| 11. | Percent of Class Represented by Amount in Row (9)<br>4.99% | Percent of Class Represented by Amount in Row (9)<br>4.99% |
| 12. | Type of Reporting Person (See Instructions)<br>OO | Type of Reporting Person (See Instructions)<br>OO |

**Comment for Type of Reporting Person:** Limited Liability Company

---

| 1. | Names of Reporting Persons<br>Jason Wood | Names of Reporting Persons<br>Jason Wood |
|:---|:---|:---|:---|
| 2. | Check the Appropriate Box if a Member of a Group (See Instructions)<br>(a) [ ] (b) [ ] | Check the Appropriate Box if a Member of a Group (See Instructions)<br>(a) [ ] (b) [ ] |
| 3. | SEC Use Only | SEC Use Only |
| 4. | Citizenship or Place of Organization<br>X1 | Citizenship or Place of Organization<br>X1 |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 5. | Sole Voting Power<br>0.00 |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 6. | Shared Voting Power<br>1000708.00 |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 7. | Sole Dispositive Power<br>0.00 |
| Number of<br>Shares<br>Beneficially<br>Owned by<br>Each<br>Reporting<br>Person<br>With | 8. | Shared Dispositive Power<br>1000708.00 |
| 9. | Aggregate Amount Beneficially Owned by Each Reporting Person<br>1000708.00 | Aggregate Amount Beneficially Owned by Each Reporting Person<br>1000708.00 |
| 10. | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) [ ] | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) [ ] |
| 11. | Percent of Class Represented by Amount in Row (9)<br>4.99% | Percent of Class Represented by Amount in Row (9)<br>4.99% |
| 12. | Type of Reporting Person (See Instructions)<br>IN | Type of Reporting Person (See Instructions)<br>IN |

---

**Item 1(a). Name of Issuer:**
Karyopharm Therapeutics Inc.

**Item 1(b). Address of Issuer's Principal Executive Offices:**
85 Wells Avenue, 2nd Floor, Newton, Massachusetts, 02459

**Item 2(a). Name of Person Filing:**
Each of the following is hereinafter individually referred to as a "Reporting Person" and collectively as the "Reporting Persons."  This statement is filed on behalf of:

J. Wood Capital Advisors LLC
Jason Wood

**Item 2(b). Address of Principal Business Office:**
The principal business address of each of the Reporting Persons is 1820 Calistoga Road, Santa Rosa, CA 95404.

**Item 2(c). Citizenship:**
J. Wood Capital Advisors LLC is organized under the laws of the State of California. Jason Wood is a citizen of the United States.

**Item 2(d). Title of Class of Securities:**
Common Stock, $0.0001 par value

**Item 2(e). CUSIP Number:**
48576U205

**Item 3. If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:**

(a) [ ] Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).

(b) [ ] Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).

(c) [ ] Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).

(d) [ ] Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8).

(e) [ ] An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);

(f) [ ] An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);

(g) [ ] A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);

(h) [ ] A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);

(i) [ ] A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);

(j) [ ] A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), if filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:

(k) [ ] Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).

**Item 4. Ownership:**

**(a) Amount beneficially owned:**

The ownership information presented below represents beneficial ownership of the shares of Common Stock, based upon 15,926,939 shares of Common Stock outstanding as of October 14, 2025, as disclosed in the Issuer's Current Report on Form 8-K filed with the Securities and Exchange Commission on October 14, 2025. The share amounts reported herein reflect a 1-for-15 reverse stock split of the Common Stock effected by the Issuer on February 24, 2025.
J. Wood Capital Advisors LLC is the record holder of 784,802 shares of Common Stock and 215,906 warrants to purchase an equal number of shares of Common Stock. The warrants contain a provision preventing exercise if such exercise would result in the Reporting Persons beneficially owning greater than 4.99% of the outstanding Common Stock when aggregated with all other shares of Common Stock beneficially owned. As a result, at any given time, the Reporting Persons may be deemed to beneficially own shares of Common Stock underlying the warrants only to the extent their total beneficial ownership does not exceed 4.99%.
Jason Wood is the managing member of J. Wood Capital Advisors LLC. As a result, Jason Wood may be deemed to share beneficial ownership of the shares of Common Stock directly held by J. Wood Capital Advisors LLC.

**(b) Percent of class:**

4.99%

**(c) Number of shares as to which the person has:**

**(i) Sole power to vote or to direct the vote:**

0

**(ii) Shared power to vote or to direct the vote:**

1,000,708

**(iii) Sole power to dispose or to direct the disposition of:**

0

**(iv) Shared power to dispose or to direct the disposition of:**

1,000,708

**Item 5. Ownership of Five Percent or Less of a Class.**

[ ] If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following.

**Item 6. Ownership of More than 5 Percent on Behalf of Another Person.**

Not Applicable

**Item 7. Identification and Classification of the Subsidiary**

Not Applicable

**Item 8. Identification and Classification of Members of the Group**

Not Applicable

**Item 9. Notice of Dissolution of Group**

Not Applicable

**Item 10. Certification:**

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

### SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**J. Wood Capital Advisors LLC**

**Date:** 11/03/2025

**By:** /s/ Jason Wood

**Name & Title:** Jason Wood, Chief Executive Officer

**Jason Wood**

**Date:** 11/03/2025

**By:** /s/ Jason Wood

**Name & Title:** Jason Wood