# EDGAR Filing Document

**Accession Number:** 0001263508
**File Stem:** 0001104659-23-021551
**Filing Date:** 2023-2
**Character Count:** 15686
**Document Hash:** ff70c1deffab433cf2ab986d93c2fe97
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-23-021551.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001104659-23-021551

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**EFFECTIVENESS DATE**: 20230214

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** BAKER BROS. ADVISORS LP
- **CENTRAL INDEX KEY:** 0001263508
- **IRS NUMBER:** 134093645
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-10519
- **FILM NUMBER:** 23628990

**BUSINESS ADDRESS:**
- **STREET 1:** 860 WASHINGTON STREET
- **STREET 2:** 3RD FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10014
- **BUSINESS PHONE:** 2123395600

**MAIL ADDRESS:**
- **STREET 1:** 860 WASHINGTON STREET
- **STREET 2:** 3RD FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10014

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** BAKER BROS ADVISORS LLC
- **DATE OF NAME CHANGE:** 20030911

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2022

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** BAKER BROS. ADVISORS LP<br>**Address:** 860 WASHINGTON STREET<br>3RD FLOOR<br>NEW YORK, NY 10014

**Form 13F File Number:** 028-10519

**CRD Number (if applicable):** 000158149

**SEC File Number (if applicable):** 801-73446

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Alexandra Toohey<br>**Title:** Chief Financial Officer<br>**Phone:** 212-339-5690

**Signature, Place, and Date of Signing:**

/s/ Alexandra Toohey  New York, NY  02-14-2023<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 113

**Form 13F Information Table Value Total:** $16651382602

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| 2seventy bio Inc. | COM | 901384107 |  | 19327911 | 2062744 | SH |  | SOLE |  | 2062744 | 0 | 0 |
| Aadi Bioscience Inc. | COM | 00032Q104 |  | 12700776 | 989928 | SH |  | SOLE |  | 989928 | 0 | 0 |
| AbCellera Biologics Inc. | COM | 00288U106 |  | 105860323 | 10450180 | SH |  | SOLE |  | 10450180 | 0 | 0 |
| ACADIA Pharmaceuticals Inc. | COM | 004225108 |  | 667421897 | 41923486 | SH |  | SOLE |  | 41923486 | 0 | 0 |
| Achilles Therapeutics plc | SPONSORED ADS | 00449L102 |  | 2332229 | 2591366 | SH |  | SOLE |  | 2591366 | 0 | 0 |
| Adaptimmune Therapeutics plc | SPONSORED ADR | 00653A107 |  | 14353080 | 9830877 | SH |  | SOLE |  | 9830877 | 0 | 0 |
| Aeglea BioTherapeutics Inc. | COM | 00773J103 |  | 1534207 | 3410106 | SH |  | SOLE |  | 3410106 | 0 | 0 |
| Aerovate Therapeutics Inc. | COM | 008064107 |  | 57922232 | 1976868 | SH |  | SOLE |  | 1976868 | 0 | 0 |
| Affimed N.V. | COM | N01045108 |  | 8180069 | 6596830 | SH |  | SOLE |  | 6596830 | 0 | 0 |
| Akero Therapeutics Inc. | COM | 00973Y108 |  | 129787114 | 2368378 | SH |  | SOLE |  | 2368378 | 0 | 0 |
| Alector Inc. | COM | 014442107 |  | 6294777 | 681991 | SH |  | SOLE |  | 681991 | 0 | 0 |
| Aligos Therapeutics Inc. | COM | 01626L105 |  | 1978602 | 2076400 | SH |  | SOLE |  | 2076400 | 0 | 0 |
| Altimmune Inc. | COM | 02155H200 |  | 10751095 | 653562 | SH |  | SOLE |  | 653562 | 0 | 0 |
| AnaptysBio Inc. | COM | 032724106 |  | 24045885 | 775924 | SH |  | SOLE |  | 775924 | 0 | 0 |
| Aravive Inc. | COM | 03890D108 |  | 4304816 | 3261224 | SH |  | SOLE |  | 3261224 | 0 | 0 |
| argenx SE | SPONSORED ADR | 04016X101 |  | 106132634 | 280159 | SH |  | SOLE |  | 280159 | 0 | 0 |
| ARS Pharmaceuticals Inc. | COM | 82835W108 |  | 17115027 | 2006451 | SH |  | SOLE |  | 2006451 | 0 | 0 |
| Ascendis Pharma A/S | SPONSORED ADR | 04351P101 |  | 605136441 | 4954855 | SH |  | SOLE |  | 4954855 | 0 | 0 |
| Atara Biotherapeutics Inc. | COM | 046513107 |  | 2440930 | 744186 | SH |  | SOLE |  | 744186 | 0 | 0 |
| Athira Pharma Inc. | COM | 04746L104 |  | 5959080 | 1879836 | SH |  | SOLE |  | 1879836 | 0 | 0 |
| Atreca Inc. | CL A COM | 04965G109 |  | 2828328 | 3532760 | SH |  | SOLE |  | 3532760 | 0 | 0 |
| aTyr Pharma Inc. | COM | 002120202 |  | 18757 | 8565 | SH |  | SOLE |  | 8565 | 0 | 0 |
| Avidity Biosciences Inc. | COM | 05370A108 |  | 9647813 | 434782 | SH |  | SOLE |  | 434782 | 0 | 0 |
| BeiGene Ltd. | SPONSORED ADR | 07725L102 |  | 2566457206 | 11668897 | SH |  | SOLE |  | 11668897 | 0 | 0 |
| Bellicum Pharmaceuticals Inc. | COM | 079481404 |  | 179369 | 249123 | SH |  | SOLE |  | 249123 | 0 | 0 |
| Bicycle Therapeutics plc | SPONSORED ADS | 088786108 |  | 24976894 | 843814 | SH |  | SOLE |  | 843814 | 0 | 0 |
| BioCryst Pharmaceuticals Inc. | COM | 09058V103 |  | 145920191 | 12710818 | SH |  | SOLE |  | 12710818 | 0 | 0 |
| Biohaven Ltd. | COM | G1110E107 |  | 6609517 | 476190 | SH |  | SOLE |  | 476190 | 0 | 0 |
| BioMarin Pharmaceutical Inc. | COM | 09061G101 |  | 788644924 | 7620494 | SH |  | SOLE |  | 7620494 | 0 | 0 |
| Biomea Fusion Inc. | COM | 09077A106 |  | 17741432 | 2104559 | SH |  | SOLE |  | 2104559 | 0 | 0 |
| bluebird bio Inc. | COM | 09609G100 |  | 17298028 | 2499715 | SH |  | SOLE |  | 2499715 | 0 | 0 |
| Cabaletta Bio Inc. | COM | 12674W109 |  | 12432000 | 1344000 | SH |  | SOLE |  | 1344000 | 0 | 0 |
| Century Therapeutics Inc. | COM | 15673T100 |  | 5896114 | 1149340 | SH |  | SOLE |  | 1149340 | 0 | 0 |
| Cerus Corporation | COM | 157085101 |  | 58646587 | 16067558 | SH |  | SOLE |  | 16067558 | 0 | 0 |
| Chinook Therapeutics Inc. | COM | 16961L106 |  | 66393472 | 2534102 | SH |  | SOLE |  | 2534102 | 0 | 0 |
| CinCor Pharma Inc. | COM | 17240Y109 |  | 9920635 | 807212 | SH |  | SOLE |  | 807212 | 0 | 0 |
| Compass Therapeutics Inc. | COM | 20454B104 |  | 7834879 | 1557630 | SH |  | SOLE |  | 1557630 | 0 | 0 |
| CymaBay Therapeutics Inc. | COM | 23257D103 |  | 13608809 | 2170464 | SH |  | SOLE |  | 2170464 | 0 | 0 |
| Cyteir Therapeutics Inc. | COM | 23284P103 |  | 4111995 | 2492118 | SH |  | SOLE |  | 2492118 | 0 | 0 |
| DBV Technologies S.A. | SPONSORED ADR | 23306J101 |  | 22359824 | 14614264 | SH |  | SOLE |  | 14614264 | 0 | 0 |
| Denali Therapeutics Inc. | COM | 24823R105 |  | 30277804 | 1088738 | SH |  | SOLE |  | 1088738 | 0 | 0 |
| Design Therapeutics Inc. | COM | 25056L103 |  | 7101264 | 692131 | SH |  | SOLE |  | 692131 | 0 | 0 |
| DICE Therapeutics Inc. | COM | 23345J104 |  | 26900858 | 862207 | SH |  | SOLE |  | 862207 | 0 | 0 |
| Edgewise Therapeutics Inc. | COM | 28036F105 |  | 4470000 | 500000 | SH |  | SOLE |  | 500000 | 0 | 0 |
| Entrada Therapeutics Inc. | COM | 29384C108 |  | 65785873 | 4865819 | SH |  | SOLE |  | 4865819 | 0 | 0 |
| Fate Therapeutics Inc. | COM | 31189P102 |  | 2176363 | 215695 | SH |  | SOLE |  | 215695 | 0 | 0 |
| FibroGen Inc. | COM | 31572Q808 |  | 22030880 | 1375211 | SH |  | SOLE |  | 1375211 | 0 | 0 |
| Foghorn Therapeutics Inc. | COM | 344174107 |  | 287272 | 45027 | SH |  | SOLE |  | 45027 | 0 | 0 |
| Genetron Holdings Limited | ADS | 37186H100 |  | 509943 | 455306 | SH |  | SOLE |  | 455306 | 0 | 0 |
| Heron Therapeutics Inc. | COM | 427746102 |  | 20329195 | 8131678 | SH |  | SOLE |  | 8131678 | 0 | 0 |
| HOOKIPA Pharma Inc. | COM | 43906K100 |  | 2815183 | 3475535 | SH |  | SOLE |  | 3475535 | 0 | 0 |
| Horizon Therapeutics Public Ltd Co | SHS | G46188101 |  | 110354933 | 969727 | SH |  | SOLE |  | 969727 | 0 | 0 |
| IDEAYA Biosciences Inc. | COM | 45166A102 |  | 30314010 | 1668355 | SH |  | SOLE |  | 1668355 | 0 | 0 |
| IGM Biosciences Inc. | COM | 449585108 |  | 53685295 | 3156102 | SH |  | SOLE |  | 3156102 | 0 | 0 |
| Immatics N.V. | SHS | N44445109 |  | 45179476 | 5187081 | SH |  | SOLE |  | 5187081 | 0 | 0 |
| Immunocore Holdings plc | ADS | 45258D105 |  | 143858118 | 2520731 | SH |  | SOLE |  | 2520731 | 0 | 0 |
| Incyte Corporation | COM | 45337C102 |  | 2903967271 | 36154971 | SH |  | SOLE |  | 36154971 | 0 | 0 |
| Insmed Incorporated | COM PAR $.01 | 457669307 |  | 398601 | 19950 | SH |  | SOLE |  | 19950 | 0 | 0 |
| Instil Bio Inc. | COM | 45783C101 |  | 3322487 | 5273789 | SH |  | SOLE |  | 5273789 | 0 | 0 |
| Invitae Corporation | COM | 46185L103 |  | 15627785 | 8402035 | SH |  | SOLE |  | 8402035 | 0 | 0 |
| iTeos Therapeutics Inc. | COM | 46565G104 |  | 2936257 | 150346 | SH |  | SOLE |  | 150346 | 0 | 0 |
| Kala Pharmaceuticals Inc. | COM | 483119202 |  | 2930416 | 76813 | SH |  | SOLE |  | 76813 | 0 | 0 |
| Kezar Life Sciences Inc. | COM | 49372L100 |  | 436100 | 61946 | SH |  | SOLE |  | 61946 | 0 | 0 |
| Kiniksa Pharmaceuticals Ltd. | COM CL A | G5269C101 |  | 41937663 | 2799577 | SH |  | SOLE |  | 2799577 | 0 | 0 |
| Kodiak Sciences Inc. | COM | 50015M109 |  | 123943108 | 17310490 | SH |  | SOLE |  | 17310490 | 0 | 0 |
| Kronos Bio Inc. | COM | 50107A104 |  | 1941005 | 1198151 | SH |  | SOLE |  | 1198151 | 0 | 0 |
| Krystal Biotech Inc. | COM | 501147102 |  | 23981162 | 302716 | SH |  | SOLE |  | 302716 | 0 | 0 |
| Kymera Therapeutics Inc. | COM | 501575104 |  | 71880432 | 2879825 | SH |  | SOLE |  | 2879825 | 0 | 0 |
| Leap Therapeutics Inc. | COM | 52187K101 |  | 251867 | 559705 | SH |  | SOLE |  | 559705 | 0 | 0 |
| MacroGenics Inc. | COM | 556099109 |  | 5989205 | 892579 | SH |  | SOLE |  | 892579 | 0 | 0 |
| Madrigal Pharmaceuticals Inc. | COM | 558868105 |  | 448469048 | 1545113 | SH |  | SOLE |  | 1545113 | 0 | 0 |
| Mirati Therapeutics Inc. | COM | 60468T105 |  | 63877313 | 1409784 | SH |  | SOLE |  | 1409784 | 0 | 0 |
| Natera Inc. | COM | 632307104 |  | 4017000 | 100000 | SH |  | SOLE |  | 100000 | 0 | 0 |
| Neoleukin Therapeutics Inc. | COM | 64049K104 |  | 1945266 | 3821740 | SH |  | SOLE |  | 3821740 | 0 | 0 |
| Nkarta Inc. | COM | 65487U108 |  | 2396000 | 400000 | SH |  | SOLE |  | 400000 | 0 | 0 |
| Nurix Therapeutics Inc. | COM | 67080M103 |  | 42625733 | 3882125 | SH |  | SOLE |  | 3882125 | 0 | 0 |
| Opthea Limited | SPONSORED ADS | 68386J208 |  | 14425856 | 2691391 | SH |  | SOLE |  | 2691391 | 0 | 0 |
| Pacific Biosciences of California Inc. | COM | 69404D108 |  | 9225257 | 1127782 | SH |  | SOLE |  | 1127782 | 0 | 0 |
| PMV Pharmaceuticals Inc. | COM | 69353Y103 |  | 2801609 | 322024 | SH |  | SOLE |  | 322024 | 0 | 0 |
| POINT Biopharma Global Inc. | COM | 730541109 |  | 8522761 | 1169103 | SH |  | SOLE |  | 1169103 | 0 | 0 |
| Praxis Precision Medicines Inc. | COM | 74006W108 |  | 4356150 | 1830315 | SH |  | SOLE |  | 1830315 | 0 | 0 |
| Prelude Therapeutics Inc. | COM | 74065P101 |  | 61147897 | 10123824 | SH |  | SOLE |  | 10123824 | 0 | 0 |
| Prime Medicine Inc. | COM | 74168J101 |  | 19108898 | 1028466 | SH |  | SOLE |  | 1028466 | 0 | 0 |
| Protara Therapeutics Inc. | COM STK | 74365U107 |  | 535118 | 199671 | SH |  | SOLE |  | 199671 | 0 | 0 |
| Reata Pharmaceuticals Inc. | CL A | 75615P103 |  | 8508848 | 223976 | SH |  | SOLE |  | 223976 | 0 | 0 |
| Replimune Group Inc. | COM | 76029N106 |  | 124529216 | 4578280 | SH |  | SOLE |  | 4578280 | 0 | 0 |
| Revolution Medicines Inc. | COM | 76155X100 |  | 5293328 | 222222 | SH |  | SOLE |  | 222222 | 0 | 0 |
| Rhythm Pharmaceuticals Inc. | COM | 76243J105 |  | 185046185 | 6354608 | SH |  | SOLE |  | 6354608 | 0 | 0 |
| Roivant Sciences Ltd. | SHS | G76279101 |  | 5726057 | 716653 | SH |  | SOLE |  | 716653 | 0 | 0 |
| Seagen Inc. | COM | 81181C104 |  | 6028695304 | 46912266 | SH |  | SOLE |  | 46912266 | 0 | 0 |
| Sera Prognostics Inc. | CLASS A COM | 81749D107 |  | 253968 | 201562 | SH |  | SOLE |  | 201562 | 0 | 0 |
| SpringWorks Therapeutics Inc. | COM | 85205L107 |  | 39757273 | 1528538 | SH |  | SOLE |  | 1528538 | 0 | 0 |
| Stoke Therapeutics Inc. | COM | 86150R107 |  | 10235267 | 1108913 | SH |  | SOLE |  | 1108913 | 0 | 0 |
| Summit Therapeutics Inc. | COM | 86627T108 |  | 8500000 | 2000000 | SH |  | SOLE |  | 2000000 | 0 | 0 |
| Surrozen Inc. | W EXP 8/11/2026 | 86889P117 |  | 45917 | 833333 | SH |  | SOLE |  | 833333 | 0 | 0 |
| Talis Biomedical Corporation | COM | 87424L108 |  | 3398389 | 7624835 | SH |  | SOLE |  | 7624835 | 0 | 0 |
| Tango Therapeutics Inc. | COM | 87583X109 |  | 5437500 | 750000 | SH |  | SOLE |  | 750000 | 0 | 0 |
| TCR2 Therapeutics Inc. | COM | 87808K106 |  | 752160 | 753064 | SH |  | SOLE |  | 753064 | 0 | 0 |
| Travere Therapeutics Inc. | COM | 89422G107 |  | 25767113 | 1225255 | SH |  | SOLE |  | 1225255 | 0 | 0 |
| TScan Therapeutics Inc. | COM | 89854M101 |  | 4316428 | 2784792 | SH |  | SOLE |  | 2784792 | 0 | 0 |
| Ultragenyx Pharmaceutical Inc. | COM | 90400D108 |  | 21820225 | 470974 | SH |  | SOLE |  | 470974 | 0 | 0 |
| Vaxcyte Inc. | COM | 92243G108 |  | 2344036 | 48885 | SH |  | SOLE |  | 48885 | 0 | 0 |
| Vera Therapeutics Inc. | CL A | 92337R101 |  | 6449994 | 333333 | SH |  | SOLE |  | 333333 | 0 | 0 |
| Verastem Inc. | COM | 92337C104 |  | 10863032 | 26988898 | SH |  | SOLE |  | 26988898 | 0 | 0 |
| Veru Inc. | COM | 92536C103 |  | 8498577 | 1609579 | SH |  | SOLE |  | 1609579 | 0 | 0 |
| Verve Therapeutics Inc. | COM | 92539P101 |  | 27409856 | 1416530 | SH |  | SOLE |  | 1416530 | 0 | 0 |
| Vincerx Pharma Inc. | COM | 92731L106 |  | 246207 | 241379 | SH |  | SOLE |  | 241379 | 0 | 0 |
| Vor Biopharma Inc. | COM | 929033108 |  | 9748401 | 1465925 | SH |  | SOLE |  | 1465925 | 0 | 0 |
| Xencor Inc. | COM | 98401F105 |  | 3206227 | 123127 | SH |  | SOLE |  | 123127 | 0 | 0 |
| Xenon Pharmaceuticals Inc. | COM | 98420N105 |  | 29637126 | 751639 | SH |  | SOLE |  | 751639 | 0 | 0 |
| Zymeworks Inc. | COM | 98985Y108 |  | 13428590 | 1708472 | SH |  | SOLE |  | 1708472 | 0 | 0 |
| Insmed Incorporated | Note 0.75% 6/1/2028 | 457669AB5 |  | 19229604 | 23500000 | PRN |  | SOLE |  | 23500000 | 0 | 0 |
| Invitae Corporation | Note 2.0% 9/1/2024 | 46185LAB9 |  | 8058143 | 10300000 | PRN |  | SOLE |  | 10300000 | 0 | 0 |

---