# EDGAR Filing Document

**Accession Number:** 0001674177
**File Stem:** 0001193125-23-001506
**Filing Date:** 2023-1
**Character Count:** 29564
**Document Hash:** 9c71c0d1e2320f5842d04f976893722d
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-23-001506.hdr.sgml**: 20230104

**ACCESSION NUMBER**: 0001193125-23-001506

**CONFORMED SUBMISSION TYPE**: SC 13D/A

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20230104

**DATE AS OF CHANGE**: 20230104

**GROUP MEMBERS**: CLAY B. THORP

**GROUP MEMBERS**: DOUGLAS REED

**GROUP MEMBERS**: HATTERAS NC FUND, LP

**GROUP MEMBERS**: HATTERAS VENTURE ADVISORS IV SBIC, LLC

**GROUP MEMBERS**: HATTERAS VENTURE ADVISORS IV, LLC

**GROUP MEMBERS**: HATTERAS VENTURE AFFILIATES III, LP

**GROUP MEMBERS**: HATTERAS VENTURE PARTNERS III, LP

**GROUP MEMBERS**: HATTERAS VENTURE PARTNERS IV SBIC, LP

**GROUP MEMBERS**: HATTERAS VENTURE PARTNERS IV, LP

**GROUP MEMBERS**: JOHN C. CRUMPLER

**GROUP MEMBERS**: KENNETH B. LEE

**GROUP MEMBERS**: ROBERT A. INGRAM

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Clearside Biomedical, Inc.
- **CENTRAL INDEX KEY:** 0001539029
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 452437375
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13D/A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-89527
- **FILM NUMBER:** 23506543

**BUSINESS ADDRESS:**
- **STREET 1:** 900 NORTH POINT PARKWAY
- **STREET 2:** SUITE 200
- **CITY:** ALPHARETTA
- **STATE:** GA
- **ZIP:** 30005
- **BUSINESS PHONE:** 678-270-3631

**MAIL ADDRESS:**
- **STREET 1:** 900 NORTH POINT PARKWAY
- **STREET 2:** SUITE 200
- **CITY:** ALPHARETTA
- **STATE:** GA
- **ZIP:** 30005
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Hatteras Venture Advisors III, LLC
- **CENTRAL INDEX KEY:** 0001674177
- **IRS NUMBER:** 204822068
- **STATE OF INCORPORATION:** NC
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13D/A

**BUSINESS ADDRESS:**
- **STREET 1:** 280 S. MANGUM STREET, SUITE 350
- **CITY:** DURHAM
- **STATE:** NC
- **ZIP:** 27701
- **BUSINESS PHONE:** 919-484-0730

**MAIL ADDRESS:**
- **STREET 1:** 280 S. MANGUM STREET, SUITE 350
- **CITY:** DURHAM
- **STATE:** NC
- **ZIP:** 27701

------

------

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**Washington, D.C. 20549** 

------

**SCHEDULE 13D** 

**(Amendment No. 6)\*** 

**Under the Securities Exchange Act of 1934** 

------

## CLEARSIDE BIOMEDICAL, INC.
**(Name of Issuer)** 

**Common Stock, $0.001 Par Value** 

**(Title of Class of Securities)** 

**185063 10 4** 

**(CUSIP Number)** 

**Clay Thorp** 

**280 S. Mangum Street, Suite 350** 

**Durham, North Carolina 27701** 

**(919) 484-0730** 

**(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)** 

**December 15, 2022** 

**(Date of Event which Requires Filing of this Statement)** 

------

If the filing person has previously filed a statement on Schedule l3G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. ☐

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**Note:** Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See § 240.13d-7 for other parties to whom copies are to be sent.

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\* The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("<u>Act</u>") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

------

CUSIP No. 185063 10 4

Page 2 of 20

1. Name of
Reporting Person I.R.S. Identification No. of Above Person (Entities Only) 20-4822068 Hatteras Venture Advisors III, LLC

2. Check the Appropriate Box if a Member
of a Group (a) ☐ (b) ☐ Not Applicable

3. SEC Use Only

4. Source of Funds (See Instructions) OO – See Item 3

5. Check if Disclosure of Legal
Proceeding Is Required Pursuant to Items 2(d) or 2(e) Not Applicable

6. Citizenship or Place of
Organization United
States

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;7. | Sole Voting Power<br>0 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;8. | Shared Voting Power<br>0 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;9. | Sole Dispositive Power<br>0 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | 10. | Shared Dispositive Power<br>0 |

---

11. Aggregate Amount Beneficially Owned by Each Reporting Person 0

12. Check Box if the Aggregate Amount in
Row (11) Excludes Certain Shares ☐

13. Percent of Class Represented by Amount
in Row (11) 0%

14. Type of Reporting Person CO

------

CUSIP No. 185063 10 4

Page 3 of 20

1. Name of
Reporting Person I.R.S. Identification No. of Above Person (Entities Only) 20-482290 Hatteras Venture Partners III, LP

2. Check the Appropriate Box if a Member
of a Group (a) ☐ (b) ☐ Not Applicable

3. SEC Use Only

4. Source of Funds (See Instructions) OO – See Item 3

5. Check if Disclosure of Legal
Proceeding Is Required Pursuant to Items 2(d) or 2(e) Not Applicable

6. Citizenship or Place of
Organization United
States

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;7. | Sole Voting Power<br>0 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;8. | Shared Voting Power<br>0 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;9. | Sole Dispositive Power<br>0 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | 10. | Shared Dispositive Power<br>0 |

---

11. Aggregate Amount Beneficially Owned by Each Reporting Person 0

12. Check Box if the Aggregate Amount in
Row (11) Excludes Certain Shares ☐

13. Percent of Class Represented by Amount
in Row (11) 0%

14. Type of Reporting Person PN

------

CUSIP No. 185063 10 4

Page 4 of 20

1. Name of
Reporting Person I.R.S. Identification No. of Above Person (Entities Only) 20-5052088 Hatteras Venture Affiliates III, LP

2. Check the Appropriate Box if a Member
of a Group (a) ☐ (b) ☐ Not Applicable

3. SEC Use Only

4. Source of Funds (See Instructions) OO – See Item 3

5. Check if Disclosure of Legal
Proceeding Is Required Pursuant to Items 2(d) or 2(e) Not Applicable

6. Citizenship or Place of
Organization United
States

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;7. | Sole Voting Power<br>0 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;8. | Shared Voting Power<br>0 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;9. | Sole Dispositive Power<br>0 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | 10. | Shared Dispositive Power<br>0 |

---

11. Aggregate Amount Beneficially Owned by Each Reporting Person 0

12. Check Box if the Aggregate Amount in
Row (11) Excludes Certain Shares ☐

13. Percent of Class Represented by Amount
in Row (11) 0%

14. Type of Reporting Person PN

------

CUSIP No. 185063 10 4

Page 5 of 20

1. Name of
Reporting Person I.R.S. Identification No. of Above Person (Entities Only) Hatteras Venture Advisors IV SBIC, LLC

2. Check the Appropriate Box if a Member
of a Group (a) ☐ (b) ☐ Not Applicable

3. SEC Use Only

4. Source of Funds (See Instructions) OO – See Item 3

5. Check if Disclosure of Legal
Proceeding Is Required Pursuant to Items 2(d) or 2(e) Not Applicable

6. Citizenship or Place of
Organization United
States

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;7. | Sole Voting Power<br>0 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;8. | Shared Voting Power<br>3,055,052 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;9. | Sole Dispositive Power<br>0 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | 10. | Shared Dispositive Power<br>3,055,052 |

---

11. Aggregate Amount Beneficially Owned by Each Reporting Person 3,055,052

12. Check Box if the Aggregate Amount in
Row (11) Excludes Certain Shares ☒

13. Percent of Class Represented by Amount
in Row (11) 5.1%

14. Type of Reporting Person CO

------

CUSIP No. 185063 10 4

Page 6 of 20

1. Name of
Reporting Person I.R.S. Identification No. of Above Person (Entities Only) 32-0389462 Hatteras Venture Partners IV SBIC, LP

2. Check the Appropriate Box if a Member
of a Group (a) ☐ (b) ☐ Not Applicable

3. SEC Use Only

4. Source of Funds (See Instructions) OO – See Item 3

5. Check if Disclosure of Legal
Proceeding Is Required Pursuant to Items 2(d) or 2(e) Not Applicable

6. Citizenship or Place of
Organization United
States

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;7. | Sole Voting Power<br>0 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;8. | Shared Voting Power<br>3,055,052 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;9. | Sole Dispositive Power<br>0 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | 10. | Shared Dispositive Power<br>3,055,052 |

---

11. Aggregate Amount Beneficially Owned by Each Reporting Person 3,055,052

12. Check Box if the Aggregate Amount in
Row (11) Excludes Certain Shares ☐

13. Percent of Class Represented by Amount
in Row (11) 5.1%

14. Type of Reporting Person CO

------

CUSIP No. 185063 10 4

Page 7 of 20

1. Name of
Reporting Person I.R.S. Identification No. of Above Person (Entities Only) 20-4822068 Hatteras Venture Advisors IV, LLC

2. Check the Appropriate Box if a Member
of a Group (a) ☐ (b) ☐ Not Applicable

3. SEC Use Only

4. Source of Funds (See Instructions) OO – See Item 3

5. Check if Disclosure of Legal
Proceeding Is Required Pursuant to Items 2(d) or 2(e) Not Applicable

6. Citizenship or Place of
Organization United
States

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;7. | Sole Voting Power<br>0 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;8. | Shared Voting Power<br>489,988 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;9. | Sole Dispositive Power<br>0 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | 10. | Shared Dispositive Power<br>489,988 |

---

11. Aggregate Amount Beneficially Owned by Each Reporting Person 489,988

12. Check Box if the Aggregate Amount in
Row (11) Excludes Certain Shares ☒

13. Percent of Class Represented by Amount
in Row (11) 0.8%

14. Type of Reporting Person CO

------

CUSIP No. 185063 10 4

Page 8 of 20

1. Name of
Reporting Person I.R.S. Identification No. of Above Person (Entities Only) 45-2827886 Hatteras Venture Partners IV, LP

2. Check the Appropriate Box if a Member
of a Group (a) ☐ (b) ☐ Not Applicable

3. SEC Use Only

4. Source of Funds (See Instructions) OO – See Item 3

5. Check if Disclosure of Legal
Proceeding Is Required Pursuant to Items 2(d) or 2(e) Not Applicable

6. Citizenship or Place of
Organization United
States

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;7. | Sole Voting Power<br>0 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;8. | Shared Voting Power<br>387,475 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;9. | Sole Dispositive Power<br>0 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | 10. | Shared Dispositive Power<br>387,475 |

---

11. Aggregate Amount Beneficially Owned by Each Reporting Person 387,475

12. Check Box if the Aggregate Amount in
Row (11) Excludes Certain Shares ☐

13. Percent of Class Represented by Amount
in Row (11) 0.6%

14. Type of Reporting Person CO

------

CUSIP No. 185063 10 4

Page 9 of 20

1. Name of
Reporting Person I.R.S. Identification No. of Above Person (Entities Only) 38-3890444 Hatteras NC Fund, LP

2. Check the Appropriate Box if a Member
of a Group (a) ☐ (b) ☐ Not Applicable

3. SEC Use Only

4. Source of Funds (See Instructions) OO – See Item 3

5. Check if Disclosure of Legal
Proceeding Is Required Pursuant to Items 2(d) or 2(e) Not Applicable

6. Citizenship or Place of
Organization United
States

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;7. | Sole Voting Power<br>0 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;8. | Shared Voting Power<br>102,513 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;9. | Sole Dispositive Power<br>0 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | 10. | Shared Dispositive Power<br>102,513 |

---

11. Aggregate Amount Beneficially Owned by Each Reporting Person 102,513

12. Check Box if the Aggregate Amount in
Row (11) Excludes Certain Shares ☐

13. Percent of Class Represented by Amount
in Row (11) 0.2%

14. Type of Reporting Person CO

------

CUSIP No. 185063 10 4

Page 10 of 20

1. Name of
Reporting Person I.R.S. Identification No. of Above Person (Entities Only) John C. Crumpler

2. Check the Appropriate Box if a Member
of a Group (a) ☐ (b) ☐ Not Applicable

3. SEC Use Only

4. Source of Funds (See Instructions) OO – See Item 3

5. Check if Disclosure of Legal
Proceeding Is Required Pursuant to Items 2(d) or 2(e) Not Applicable

6. Citizenship or Place of
Organization United
States

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;7. | Sole Voting Power<br>5,174 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;8. | Shared Voting Power<br>3,545,040 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;9. | Sole Dispositive Power<br>5,174 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | 10. | Shared Dispositive Power<br>3,545,040 |

---

11. Aggregate Amount Beneficially Owned by Each Reporting Person $3,550,214

12. Check Box if the Aggregate Amount in
Row (11) Excludes Certain Shares ☐

13. Percent of Class Represented by Amount
in Row (11) 5.9%

14. Type of Reporting Person IN

------

CUSIP No. 185063 10 4

Page 11 of 20

1. Name of
Reporting Person I.R.S. Identification No. of Above Person (Entities Only) Robert A. Ingram

2. Check the Appropriate Box if a Member
of a Group (a) ☐ (b) ☐ Not Applicable

3. SEC Use Only

4. Source of Funds (See Instructions) OO – See Item 3

5. Check if Disclosure of Legal
Proceeding Is Required Pursuant to Items 2(d) or 2(e) Not Applicable

6. Citizenship or Place of
Organization United
States

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;7. | Sole Voting Power<br>10,262 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;8. | Shared Voting Power<br>3,545,040 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;9. | Sole Dispositive Power<br>10,262 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | 10. | Shared Dispositive Power<br>3,545,040 |

---

11. Aggregate Amount Beneficially Owned by Each Reporting Person $3,555,302

12. Check Box if the Aggregate Amount in
Row (11) Excludes Certain Shares ☐

13. Percent of Class Represented by Amount
in Row (11) 5.9%

14. Type of Reporting Person IN

------

CUSIP No. 185063 10 4

Page 12 of 20

1. Name of
Reporting Person I.R.S. Identification No. of Above Person (Entities Only) Kenneth B. Lee

2. Check the Appropriate Box if a Member
of a Group (a) ☐ (b) ☐ Not Applicable

3. SEC Use Only

4. Source of Funds (See Instructions) OO – See Item 3

5. Check if Disclosure of Legal
Proceeding Is Required Pursuant to Items 2(d) or 2(e) Not Applicable

6. Citizenship or Place of
Organization United
States

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;7. | Sole Voting Power<br>5,174 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;8. | Shared Voting Power<br>3,545,040 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;9. | Sole Dispositive Power<br>5,174 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | 10. | Shared Dispositive Power<br>3,545,040 |

---

11. Aggregate Amount Beneficially Owned by Each Reporting Person $3,550,214

12. Check Box if the Aggregate Amount in
Row (11) Excludes Certain Shares ☐

13. Percent of Class Represented by Amount
in Row (11) 5.9%

14. Type of Reporting Person IN

------

CUSIP No. 185063 10 4

Page 13 of 20

1. Name of
Reporting Person I.R.S. Identification No. of Above Person (Entities Only) Clay B. Thorp

2. Check the Appropriate Box if a Member
of a Group (a) ☐ (b) ☐ Not Applicable

3. SEC Use Only

4. Source of Funds (See Instructions) OO – See Item 3

5. Check if Disclosure of Legal
Proceeding Is Required Pursuant to Items 2(d) or 2(e) Not Applicable

6. Citizenship or Place of
Organization United
States

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;7. | Sole Voting Power<br>109,022 <sup>(1)</sup> |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;8. | Shared Voting Power<br>3,545,040 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;9. | Sole Dispositive Power<br>109,022 <sup>(1)</sup> |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | 10. | Shared Dispositive Power<br>3,545,040 |

---

11. Aggregate Amount Beneficially Owned by Each Reporting Person 3,654,062

12. Check Box if the Aggregate Amount in
Row (11) Excludes Certain Shares ☐

13. Percent of Class Represented by Amount
in Row (11) 6.1%

14. Type of Reporting Person IN

------

<sup>1</sup> Includes 16,522 shares held directly by the Reporting Person and 92,500 shares of Common Stock subject to options held by the Reporting Person that are exercisable within 60 days of December 20, 2022.

------

CUSIP No. 185063 10 4

Page 14 of 20

1. Name of
Reporting Person I.R.S. Identification No. of Above Person (Entities Only) Douglas Reed

2. Check the Appropriate Box if a Member
of a Group (a) ☐ (b) ☐ Not Applicable

3. SEC Use Only

4. Source of Funds (See Instructions) OO – See Item 3

5. Check if Disclosure of Legal
Proceeding Is Required Pursuant to Items 2(d) or 2(e) Not Applicable

6. Citizenship or Place of
Organization United
States

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;7. | Sole Voting Power<br>6,392 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;8. | Shared Voting Power<br>3,545,040 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | &nbsp;&nbsp;&nbsp;&nbsp;9. | Sole Dispositive Power<br>6,392 |
| &nbsp;&nbsp;&nbsp; Number of <br> Shares <br> Beneficially <br> Owned By <br> Each <br> Reporting <br> Person <br> with  | 10. | Shared Dispositive Power<br>3,545,040 |

---

11. Aggregate Amount Beneficially Owned by Each Reporting Person 3,551,432

12. Check Box if the Aggregate Amount in
Row (11) Excludes Certain Shares ☐

13. Percent of Class Represented by Amount
in Row (11) 5.9%

14. Type of Reporting Person IN

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This Amendment No. 6 on Schedule 13D amends the statement on Schedule 13D, dated June 7, 2016, which relates to the Common Stock, par value $0.001 per share (the "**Common Stock**") of Clearside Biomedical, Inc. (the "**Issuer**") which was previously amended on Schedule 13D/A, dated January 20 and April 17, 2017, March 21, 2018 and July 17 and December 4, 2019 filed by:

Hatteras Venture Advisors III, LLC ("**HVA III**")

Hatteras Venture Partners III, LP ("**HVP III**")

Hatteras Venture Affiliates III, LP ("**HV Affiliates**")

Hatteras Venture Advisors IV SBIC, LLC ("**HVA SBIC**")

Hatteras Venture Partners IV SBIC, LP ("**HVP SBIC**")

Hatteras Venture Advisors IV, LLC ("**HVA IV**")

Hatteras Venture Partners IV, LP ("**HVP IV**")

Hatteras NC Fund, LP ("**Hatteras Fund**")

John C. Crumpler

Robert A. Ingram

Kenneth B. Lee

Clay B. Thorp

Douglas Reed

(collectively, the "**Reporting Persons**").

Except as expressly amended below, the Schedule 13D, dated June 7, 2016, remains in effect.

**Item 5.** **Interest in Securities of the Issuer.** <br>

(a) Aggregate number and percentage beneficially owned:

HVA III — 0 or 0%

HVP III — 0 or 0%

HV Affiliates — 0 or 0%

HVA SBIC— 3,055,052 or 5.1%

HVP SBIC — 3,055,052 or 5.1%

HVA IV— 489,988 or less than 1%

HVP IV — 387,475 or less than 1%

Hatteras Fund— 102,513 or less than 1%

John C. Crumpler — 3,550,214 or 5.9%

Robert A. Ingram — 3,555,302 or 5.9%

Kenneth B. Lee — 3,550,214 or 5.9%

Clay B. Thorp — 3,654,062 or 6.1%

Douglas Reed — 3,551,432 or 5.9%

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Number of shares as to which the person has:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) Sole power to vote or to direct the vote

HVA III — 0

HVP III — 0

HV Affiliates — 0

HVA SBIC— 0

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CUSIP No. 185063 10 4

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HVP SBIC — 0

HVA IV— 0

HVP IV — 0

Hatteras Fund— 0

John C. Crumpler — 5,174

Robert A. Ingram — 10,262

Kenneth B. Lee — 5,174

Clay B. Thorp — 109,022

Douglas Reed — 6,392

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) Sole power to dispose or to direct the disposition of

HVA III — 0

HVP III — 0

HV Affiliates — 0

HVA SBIC— 0

HVP SBIC — 0

HVA IV— 0

HVP IV — 0

Hatteras Fund— 0

John C. Crumpler — 5,174

Robert A. Ingram — 10,262

Kenneth B. Lee — 5,174

Clay B. Thorp — 109,022

Douglas Reed — 6,392

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) Shared power to dispose or to direct the disposition of

HVA III — 0

HVP III — 0

HV Affiliates — 0

HVA SBIC— 3,055,052

HVP SBIC — 3,055,052

HVA IV— 489,988

HVP IV — 387,475

Hatteras Fund— 102,513

John C. Crumpler — 3,545,040

Robert A. Ingram — 3,545,040

Kenneth B. Lee — 3,545,040

Clay B. Thorp — 3,545,040

Douglas Reed — 3,545,040

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) Shared power to vote or to direct the vote

HVA III — 0

HVP III — 0

HV Affiliates — 0

HVA SBIC— 3,055,052

HVP SBIC — 3,055,052

HVA IV— 489,988

HVP IV — 387,475

Hatteras Fund— 102,513

John C. Crumpler — 3,545,040

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Robert A. Ingram — 3,545,040

Kenneth B. Lee — 3,545,040

Clay B. Thorp — 3,545,040

Douglas Reed — 3,545,040

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Each of the required transactions described in this Item 5(a) were reported on Forms 4 filed by Mr. Thorp filed with the Securities and Exchange Commission (the "**SEC**") pursuant to Section 16 of the Act and are available on the SEC's website at www.sec.gov, except for the following:

[insert details related to the distributions-in-kind as the final details were not reported on Forms 4]

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**SIGNATURE** 

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Date: January 4, 2023

---

| | |
|:---|:---|
| HATTERAS VENTURE ADVISORS III, LLC | HATTERAS VENTURE ADVISORS III, LLC |
| By: | /s/ Clay B. Thorp |
|  | Manager |
| HATTERAS VENTURE PARTNERS III, LP | HATTERAS VENTURE PARTNERS III, LP |
| By: | Hatteras Venture Advisors III, LLC, its general partner |
| By: | /s/ Clay B. Thorp |
|  | Manager |
| HATTERAS VENTURE AFFILIATES III, LP | HATTERAS VENTURE AFFILIATES III, LP |
| By: | Hatteras Venture Advisors III, LLC, its general partner |
| By: | /s/ Clay B. Thorp |
|  | Manager |
| HATTERAS VENTURE ADVISORS IV SBIC, LLC | HATTERAS VENTURE ADVISORS IV SBIC, LLC |
| By: | /s/ Clay B. Thorp |
|  | Manager |

---

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---

| | |
|:---|:---|
| HATTERAS VENTURE PARTNERS IV SBIC, LP | HATTERAS VENTURE PARTNERS IV SBIC, LP |
| By: | Hatteras Venture Advisors IV SBIC, LLC, its general partner |
| By: | /s/ Clay B. Thorp |
|  | Manager |
| HATTERAS VENTURE ADVISORS IV, LLC | HATTERAS VENTURE ADVISORS IV, LLC |
| By: | /s/ Clay B. Thorp |
|  | Manager |
| HATTERAS VENTURE PARTNERS IV, LP | HATTERAS VENTURE PARTNERS IV, LP |
| By: | Hatteras Venture Advisors IV, LLC, its general partner |
| By: | /s/ Clay B. Thorp |
|  | Manager |
| HATTERAS NC FUND, LP | HATTERAS NC FUND, LP |
| By: | Hatteras Venture Advisors IV, LLC, its general partner |
| By: | /s/ Clay B. Thorp |
|  | Manager |
| \* | \* |
| John C. Crumpler | John C. Crumpler |
| \* | \* |
| Robert A. Ingram | Robert A. Ingram |
| \* | \* |
| Kenneth B. Lee | Kenneth B. Lee |

---

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---

| | |
|:---|:---|
| \* | \* |
| Clay B. Thorp | Clay B. Thorp |
| \* | \* |
| Douglas Reed | Douglas Reed |
| By: | /s/ Clay B. Thorp |
|  | Clay B. Thorp, as Attorney-in-Fact |

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This Amendment No. 6 to Schedule 13D was executed by Clay B. Thorp on behalf of the individuals listed above pursuant to a Power of Attorney a copy of which was previously filed with the Reporting Person's Schedule 13D filed with the SEC on June 17, 2016 and as amended on February 8 and April 25, 2017, March 21, 2018 and July 17 and December 4, 2019.