# EDGAR Filing Document

**Accession Number:** 0001424958
**File Stem:** 0001193125-26-287439
**Filing Date:** 2026-6
**Character Count:** 59842
**Document Hash:** 33f89019208d16fb132be8880da7c415
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-26-287439.hdr.sgml**: 20260629

**ACCESSION NUMBER**: 0001193125-26-287439

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20260430

**FILED AS OF DATE**: 20260629

**DATE AS OF CHANGE**: 20260629

**PERIOD START**: 20261031

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Direxion Shares ETF Trust
- **CENTRAL INDEX KEY:** 0001424958

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1031

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-22201
- **FILM NUMBER:** 261132165

**BUSINESS ADDRESS:**
- **STREET 1:** 535 MADISON AVENUE
- **STREET 2:** 37TH FL.
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10022
- **BUSINESS PHONE:** 646-572-3390

**MAIL ADDRESS:**
- **STREET 1:** 535 MADISON AVENUE
- **STREET 2:** 37TH FL.
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10022

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Direxion ETF Trust
- **DATE OF NAME CHANGE:** 20080124

## Series and Classes Contracts Data

### Direxion Daily S&P Biotech Bull 3X ETF (Series ID: S000049373)

| Class ID   | Class Name                             | Ticker Symbol   |
|:---|:---|:---|
| C000156149 | Direxion Daily S&P Biotech Bull 3X ETF | LABU            |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** Direxion Shares ETF Trust

- **b. Investment Company Act file number:** 811-22201

- **c. CIK number of Registrant:** 0001424958

- **d. LEI of Registrant:** 549300M501IVJM50FG12

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 1301 Avenue of the Americas (6th Avenue)

  - **City:** New York

  - **State:** NY

  - **Foreign country:** US

  - **Zip / Postal Code:** 10019

  - **Telephone number:** 646-572-3390

**Item A.2. Information about the Series.**

- **a. Name of Series:** Direxion Daily S&P Biotech Bull 3X Shares

- **b. EDGAR series identifier (if any):** S000049373

- **c. LEI of Series:** 549300WNBLZ8IWC9IW36

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2026-10-31

- **b. Date as of which information is reported:** 2026-04-30

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $578962720.39

**Total Liabilities:** $60073155.25

**Net Assets:** $518889565.14

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000156149 | 4.11%                | -3.74%               | 6.73%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $6022226.42              | $1101405.69                                |
| Month 2  | $-10646095.53            | $15299914.10                               |
| Month 3  | $25713444.25             | $-14603392.75                              |

### Schedule of Portfolio Investments

| Name                             | Title                                                               | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| ADMA BIOLOGICS INC               | Adma Biologics Inc COM USD0.0001                                    | CUSIP: 000899104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    281674 | NS      | $2887158.50   | 0.56%             |  |  |  | No            |                  1 | On Loan: No      |
| Absci Corp.                      | ABSCI CORP                                                          | CUSIP: 00091E109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    259355 | NS      | $1290291.13   | 0.25%             |  |  |  | No            |                  1 | On Loan: —       |
| AbbVie Inc.                      | AbbVie Inc. COM USD0.01                                             | CUSIP: 00287Y109<br>LEI: FR5LCKFTG8054YNNRU85 | Long             | EC               | CORP              | US        |     21322 | NS      | $4505765.04   | 0.87%             |  |  |  | No            |                  1 | On Loan: No      |
| ACADIA PHARMACEUTICALS INC       | Acadia Pharmaceuticals Inc COM USD0.0001                            | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |    195542 | NS      | $4389917.90   | 0.85%             |  |  |  | No            |                  1 | On Loan: No      |
| Invivyd Inc                      | INVIVYD INC                                                         | CUSIP: 00534A102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    329668 | NS      | $461535.20    | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Spyre Therapeutics Inc           | SPYRE THERAPEUTICS INC                                              | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |     61270 | NS      | $4561551.50   | 0.88%             |  |  |  | No            |                  1 | On Loan: —       |
| Agios Pharmaceuticals Inc        | Agios Pharmaceuticals Inc COM USD0.001                              | CUSIP: 00847X104<br>LEI: 529900ONJHY8EOGYT555 | Long             | EC               | CORP              | US        |    110585 | NS      | $3096380.00   | 0.60%             |  |  |  | No            |                  1 | On Loan: No      |
| Akebia Therapeutics Inc.         | AKEBIA THERAPEUTICS INC                                             | CUSIP: 00972D105<br>LEI: 549300CBQEHMKEEGNX42 | Long             | EC               | CORP              | US        |    352079 | NS      | $485869.02    | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| NOVOB DC CVR                     | NOVOB DC CVR                                                        | CUSIP: 009CVR044<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    128720 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| ALLOGENE THERAPEUTICS INC        | ALLOGENE THERAPEUTICS INC                                           | CUSIP: 019770106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    303899 | NS      | $647304.87    | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| ALNYLAM PHARMACEUTICALS INC      | Alnylam Pharmaceuticals Inc. COM USD0.01                            | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |     15151 | NS      | $4689082.99   | 0.90%             |  |  |  | No            |                  1 | On Loan: No      |
| Altimmune Inc.                   | ALTIMMUNE INC                                                       | CUSIP: 02155H200<br>LEI: 549300EOYCQ8SW3NVE64 | Long             | EC               | CORP              | US        |    248923 | NS      | $647199.80    | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Amgen Inc.                       | Amgen Inc. COM USD0.0001                                            | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |     12853 | NS      | $4450351.25   | 0.86%             |  |  |  | No            |                  1 | On Loan: No      |
| AnaptysBio Inc.                  | ANAPTYSBIO INC                                                      | CUSIP: 032724106<br>LEI: 529900HH4WQT03IG1A12 | Long             | EC               | CORP              | US        |     29328 | NS      | $1927729.44   | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Anavex Life Sciences Corp.       | Anavex Life Sciences Corp. USD0.001                                 | CUSIP: 032797300<br>LEI: 549300K1I5L8COCQ8W36 | Long             | EC               | CORP              | US        |    154727 | NS      | $516788.18    | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Annexon Inc                      | ANNEXON INC                                                         | CUSIP: 03589W102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    218784 | NS      | $1284262.08   | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Apellis Pharmaceuticals Inc      | Apellis Pharmaceuticals Inc COM USD0.0001                           | CUSIP: 03753U106<br>LEI: 254900HS0ZFRXXSB9D42 | Long             | EC               | CORP              | US        |    194250 | NS      | $7954537.50   | 1.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Apogee Therapeutics Inc.         | APOGEE THERAPEUTICS INC                                             | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     65006 | NS      | $5388347.34   | 1.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Arbutus Biopharma Corp.          | ARBUTUS BIOPHARMA CORP                                              | CUSIP: 03879J100<br>LEI: 25490064CESONAUIAS23 | Long             | EC               | CORP              | CA        |    132235 | NS      | $555387.00    | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Ardelyx Inc                      | ARDELYX INC                                                         | CUSIP: 039697107<br>LEI: 549300F542QR4SXHCY32 | Long             | EC               | CORP              | US        |    438991 | NS      | $2778813.03   | 0.54%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcus Biosciences Inc.           | Arcus Biosciences Inc. COM USD0.0001                                | CUSIP: 03969F109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    123926 | NS      | $3160113.00   | 0.61%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcutis Biotherapeutics Inc.     | ARCUTIS BIOTHERAPEUTICS INC                                         | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    196991 | NS      | $4574131.02   | 0.88%             |  |  |  | No            |                  1 | On Loan: No      |
| ArriVent BioPharma Inc.          | ARRIVENT BIOPHARMA INC                                              | CUSIP: 04272N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     40097 | NS      | $1246615.73   | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| ARROWHEAD PHARMACEUTICALS INC    | Arrowhead Pharmaceuticals Inc COM USD0.001                          | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |     83558 | NS      | $6139841.84   | 1.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Bicara Therapeutics Inc.         | BICARA THERAPEUTICS INC                                             | CUSIP: 055477103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     40903 | NS      | $882686.74    | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Beam Therapeutics Inc.           | Beam Therapeutics Incorporation COM                                 | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    186154 | NS      | $5646050.82   | 1.09%             |  |  |  | No            |                  1 | On Loan: —       |
| BIOCRYST PHARMACEUTICALS INC     | BioCryst Pharmaceuticals Inc. COM USD0.01                           | CUSIP: 09058V103<br>LEI: 549300Z0INP1Z5NP6J59 | Long             | EC               | CORP              | US        |    381305 | NS      | $3492753.80   | 0.67%             |  |  |  | No            |                  1 | On Loan: No      |
| Biomarin Pharmaceutical Inc.     | Biomarin Pharmaceutical Inc. COM USD0.001                           | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |     80485 | NS      | $4338946.35   | 0.84%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen Inc                       | Biogen Inc COM USD0.0005                                            | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |     25484 | NS      | $4823611.52   | 0.93%             |  |  |  | No            |                  1 | On Loan: No      |
| Bridgebio Pharma Inc             | Bridgebio Pharma Inc COM USD0.001                                   | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |     68003 | NS      | $4835693.33   | 0.93%             |  |  |  | No            |                  1 | On Loan: —       |
| CAPRICOR THERAPEUTICS INC        | CAPRICOR THERAPEUTICS INC                                           | CUSIP: 14070B309<br>LEI: 5493002ZI5PDLXV4DX14 | Long             | EC               | CORP              | US        |     67108 | NS      | $2253486.64   | 0.43%             |  |  |  | No            |                  1 | On Loan: No      |
| Caredx Inc                       | Caredx Inc COM USD0.001                                             | CUSIP: 14167L103<br>LEI: 549300NQOFKL9NON0U06 | Long             | EC               | CORP              | US        |     84742 | NS      | $1763481.02   | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Catalyst Pharmaceuticals Inc.    | Catalyst Pharmaceuticals Inc. COM STK USD0.001                      | CUSIP: 14888U101<br>LEI: 5299004O0R5XXLA5H544 | Long             | EC               | CORP              | US        |    129949 | NS      | $3655465.37   | 0.70%             |  |  |  | No            |                  1 | On Loan: No      |
| Celcuity Inc.                    | CELCUITY INC                                                        | CUSIP: 15102K100<br>LEI: 25490070W7UU7W2SEY87 | Long             | EC               | CORP              | US        |     41941 | NS      | $5089540.35   | 0.98%             |  |  |  | No            |                  1 | On Loan: No      |
| Celldex Therapeutics Inc.        | Celldex Therapeutics Inc. COM USD0.001(POST REV SPLT                | CUSIP: 15117B202<br>LEI: 529900F018DMYWH38923 | Long             | EC               | CORP              | US        |     70017 | NS      | $2302158.96   | 0.44%             |  |  |  | No            |                  1 | On Loan: No      |
| CG Oncology Inc.                 | CG ONCOLOGY INC                                                     | CUSIP: 156944100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     73170 | NS      | $4883365.80   | 0.94%             |  |  |  | No            |                  1 | On Loan: No      |
| Cogent Biosciences Inc.          | Cogent Biosciences Inc. COM                                         | CUSIP: 19240Q201<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    134554 | NS      | $4815687.66   | 0.93%             |  |  |  | No            |                  1 | On Loan: No      |
| Compass Therapeutics Inc         | COMPASS THERAPEUTICS INC                                            | CUSIP: 20454B104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    210822 | NS      | $373154.94    | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Corvus Pharmaceuticals Inc       | CORVUS PHARMACEUTICALS INC                                          | CUSIP: 221015100<br>LEI: 549300I3AVJ8F75NCX65 | Long             | EC               | CORP              | US        |    121201 | NS      | $1841043.19   | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Cullinan Therapeutics Inc        | CULLINAN ONCOLOGY INC                                               | CUSIP: 230031106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     74789 | NS      | $975996.45    | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytokinetics Inc                 | Cytokinetics Inc COM USD0.001                                       | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |     76297 | NS      | $4880719.09   | 0.94%             |  |  |  | No            |                  1 | On Loan: —       |
| Cytomx Therapeutics Inc          | CYTOMX THERAPEUTICS INC                                             | CUSIP: 23284F105<br>LEI: 5493004VW2FW0QLL3345 | Long             | EC               | CORP              | US        |    258130 | NS      | $1089308.60   | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Denali Therapeutics Inc          | Denali Therapeutics Inc COM USD0.01                                 | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |    162191 | NS      | $3036215.52   | 0.59%             |  |  |  | No            |                  1 | On Loan: No      |
| Dianthus Therapeutics Inc        | DIANTHUS THERAPEUTICS INC                                           | CUSIP: 252828108<br>LEI: 549300Z3N6ODPCOFC890 | Long             | EC               | CORP              | US        |     33605 | NS      | $2950519.00   | 0.57%             |  |  |  | No            |                  1 | On Loan: No      |
| Disc Medicine Inc                | DISC MEDICINE INC                                                   | CUSIP: 254604101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     57978 | NS      | $3823649.10   | 0.74%             |  |  |  | No            |                  1 | On Loan: —       |
| Dyne Therapeutics Inc.           | DYNE THERAPEUTICS INC                                               | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    196941 | NS      | $3456314.55   | 0.67%             |  |  |  | No            |                  1 | On Loan: No      |
| Emergent Biosolutions Inc        | EMERGENT BIOSOLUTIONS INC                                           | CUSIP: 29089Q105<br>LEI: 549300YW6TUOX8BE5103 | Long             | EC               | CORP              | US        |     91705 | NS      | $754732.15    | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Erasca Inc                       | ERASCA INC                                                          | CUSIP: 29479A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    271194 | NS      | $2888216.10   | 0.56%             |  |  |  | No            |                  1 | On Loan: No      |
| EXELIXIS INC                     | Exelixis, Inc. COM USD0.001                                         | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |    116281 | NS      | $5169853.26   | 1.00%             |  |  |  | No            |                  1 | On Loan: No      |
| FIRST TRACKS BIOTHERAPEUTICS INC | FIRST TRACKS BIOTHERAPEUTICS                                        | CUSIP: 337185102<br>LEI: 529900CGIGKN4R5RO925 | Long             | EC               | CORP              | US        |     29328 | NS      | $682462.56    | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| 4D MOLECULAR THERAPEUTICS INC    | 4D MOLECULAR THERAPEUTICS IN                                        | CUSIP: 35104E100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     76847 | NS      | $681632.89    | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| DAMORA THERAPEUTICS INC          | DAMORA THERAPEUTICS INC                                             | CUSIP: 36322Q206<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5472 | NS      | $140411.52    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| GERON CORP                       | Geron Corp. COM USD0.001                                            | CUSIP: 374163103<br>LEI: 549300T282D7Z2YESL90 | Long             | EC               | CORP              | US        |    951040 | NS      | $1464601.60   | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Gilead Sciences Inc.             | Gilead Sciences, Inc. COM USD0.001                                  | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |     33255 | NS      | $4351084.20   | 0.84%             |  |  |  | No            |                  1 | On Loan: No      |
| GRAIL Inc                        | GRAIL INC                                                           | CUSIP: 384747101<br>LEI: 2549009XSNESW3VE8024 | Long             | EC               | CORP              | US        |     59651 | NS      | $3249786.48   | 0.63%             |  |  |  | No            |                  1 | On Loan: —       |
| Halozyme Therapeutics Inc        | Halozyme Therapeutics Inc COM USD0.001                              | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |     73023 | NS      | $4648644.18   | 0.90%             |  |  |  | No            |                  1 | On Loan: No      |
| HYPERLIQUID STRATEGIES INC       | HYPERLIQUID STRATEGIES                                              | CUSIP: 44916Y106<br>LEI: 98450073FF7E1B63N260 | Long             | EC               | CORP              | US        |    142920 | NS      | $860378.40    | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| IDEAYA Biosciences Inc.          | IDEAYA Biosciences Inc. COM USD0.0001                               | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |     93300 | NS      | $2715030.00   | 0.52%             |  |  |  | No            |                  1 | On Loan: —       |
| ImmunityBio Inc                  | IMMUNITYBIO INC                                                     | CUSIP: 45256X103<br>LEI: 529900J9XLBR4HFL4B83 | Long             | EC               | CORP              | US        |    587041 | NS      | $4167991.10   | 0.80%             |  |  |  | No            |                  1 | On Loan: —       |
| Immunome Inc                     | IMMUNOME INC                                                        | CUSIP: 45257U108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    168145 | NS      | $3857246.30   | 0.74%             |  |  |  | No            |                  1 | On Loan: No      |
| Immunovant Inc                   | Immunovant Inc COM                                                  | CUSIP: 45258J102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    147047 | NS      | $3991590.82   | 0.77%             |  |  |  | No            |                  1 | On Loan: —       |
| Incyte Corporation.              | Incyte Corporation. COM USD0.001                                    | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |     51287 | NS      | $4886112.49   | 0.94%             |  |  |  | No            |                  1 | On Loan: No      |
| Inhibrx Biosciences Inc.         | INHIBRX BIOSCIENCES INC                                             | CUSIP: 45720N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     16961 | NS      | $2191530.81   | 0.42%             |  |  |  | No            |                  1 | On Loan: No      |
| Insmed Inc                       | Insmed Inc COM USD0.01                                              | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |     34830 | NS      | $4748373.90   | 0.92%             |  |  |  | No            |                  1 | On Loan: No      |
| INHIBRX INC CVR                  | INHIBRX INC CVR                                                     | CUSIP: 457CVR017<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    164173 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Intellia Therapeutics Inc        | Intellia Therapeutics Inc COM USD0.0001                             | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |    215007 | NS      | $2898294.36   | 0.56%             |  |  |  | No            |                  1 | On Loan: —       |
| Ionis Pharmaceuticals, Inc.      | Ionis Pharmaceuticals, Inc. COM USD0.001                            | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |     64911 | NS      | $4852746.36   | 0.94%             |  |  |  | No            |                  1 | On Loan: No      |
| Iovance Biotherapeutics Inc      | Iovance Biotherapeutics Inc COM USD0.000041666                      | CUSIP: 462260100<br>LEI: 2549002L8WT2ACU5Q878 | Long             | EC               | CORP              | US        |    466051 | NS      | $1565931.36   | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Ironwood Pharmaceuticals, Inc.   | IRONWOOD PHARMACEUTICALS INC                                        | CUSIP: 46333X108<br>LEI: 549300PC8MR6QHH6P296 | Long             | EC               | CORP              | US        |    233156 | NS      | $961768.50    | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| PERSPECTIVE THERAPEUTICS INC     | PERSPECTIVE THERAPEUTICS INC                                        | CUSIP: 46489V302<br>LEI: 5493005LRKM6BCABC605 | Long             | EC               | CORP              | US        |     99897 | NS      | $389598.30    | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Janux Therapeutics Inc           | JANUX THERAPEUTICS INC                                              | CUSIP: 47103J105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     81512 | NS      | $1171327.44   | 0.23%             |  |  |  | No            |                  1 | On Loan: —       |
| KALVISTA PHARMACEUTICALS INC     | KALVISTA PHARMACEUTICALS INC                                        | CUSIP: 483497103<br>LEI: 529900Q7IDA3WUGRZA51 | Long             | EC               | CORP              | US        |     61671 | NS      | $1644148.86   | 0.32%             |  |  |  | No            |                  1 | On Loan: No      |
| Kodiak Sciences Inc              | KODIAK SCIENCES INC                                                 | CUSIP: 50015M109<br>LEI: 254900IXI5NI8C9OQE24 | Long             | EC               | CORP              | US        |     76962 | NS      | $3346307.76   | 0.64%             |  |  |  | No            |                  1 | On Loan: No      |
| Krystal Biotech Inc              | Krystal Biotech Inc COM USD0.00001                                  | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |     19037 | NS      | $4992643.62   | 0.96%             |  |  |  | No            |                  1 | On Loan: —       |
| Kura Oncology Inc.               | Kura Oncology Incorporation COM USD0.0001                           | CUSIP: 50127T109<br>LEI: 5493005QORQTZCZYOP39 | Long             | EC               | CORP              | US        |    144395 | NS      | $1275007.85   | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Kymera Therapeutics Inc          | Kymera Therapeutics Inc COM                                         | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     59553 | NS      | $4827961.71   | 0.93%             |  |  |  | No            |                  1 | On Loan: —       |
| Lexeo Therapeutics Inc           | LEXEO THERAPEUTICS INC                                              | CUSIP: 52886X107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    108595 | NS      | $618448.53    | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Madrigal Pharmaceuticals Inc     | Madrigal Pharmaceuticals Inc USD0.0001                              | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |     11249 | NS      | $5820120.11   | 1.12%             |  |  |  | No            |                  1 | On Loan: No      |
| MANNKIND CORP                    | Mannkind Corporation COM USD0.01                                    | CUSIP: 56400P706<br>LEI: 213800GFBCNY1ZFST722 | Long             | EC               | CORP              | US        |    625921 | NS      | $1771356.43   | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| MiMedx Group Inc.                | MiMedx Group Inc. COM USD0.001                                      | CUSIP: 602496101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    133086 | NS      | $447168.96    | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Mineralys Therapeutics Inc.      | MINERALYS THERAPEUTICS INC                                          | CUSIP: 603170101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    101556 | NS      | $2706467.40   | 0.52%             |  |  |  | No            |                  1 | On Loan: No      |
| Mirum Pharmaceuticals Inc.       | Mirum Pharmaceuticals Inc. COM USD0.0001                            | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |     52917 | NS      | $5149353.27   | 0.99%             |  |  |  | No            |                  1 | On Loan: No      |
| Moderna Inc                      | Moderna Inc COM USD0.0001                                           | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |     86741 | NS      | $3984881.54   | 0.77%             |  |  |  | No            |                  1 | On Loan: No      |
| Monte Rosa Therapeutics Inc      | MONTE ROSA THERAPEUTICS INC                                         | CUSIP: 61225M102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    112609 | NS      | $2156462.35   | 0.42%             |  |  |  | No            |                  1 | On Loan: No      |
| Myriad Genetics Inc.             | Myriad Genetics Inc. COM USD0.01                                    | CUSIP: 62855J104<br>LEI: 52990044IHUOUMETT163 | Long             | EC               | CORP              | US        |    125944 | NS      | $598234.00    | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Natera Inc.                      | Natera Incorporation COM USD0.0001                                  | CUSIP: 632307104<br>LEI: 529900CQ3OZ0A0VYVU59 | Long             | EC               | CORP              | US        |     24696 | NS      | $5091327.36   | 0.98%             |  |  |  | No            |                  1 | On Loan: No      |
| NEUROCRINE BIOSCIENCES INC       | Neurocrine Biosciences Inc COM USD0.001                             | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |     37476 | NS      | $4934464.92   | 0.95%             |  |  |  | No            |                  1 | On Loan: No      |
| Novavax Inc                      | NOVAVAX INC                                                         | CUSIP: 670002401<br>LEI: 529900J4GJHPEPQ23205 | Long             | EC               | CORP              | US        |    267379 | NS      | $2118978.58   | 0.41%             |  |  |  | No            |                  1 | On Loan: —       |
| NUVALENT INC                     | NUVALENT INC                                                        | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     48521 | NS      | $4865685.88   | 0.94%             |  |  |  | No            |                  1 | On Loan: No      |
| Nurix Therapeutics Inc.          | NURIX THERAPEUTICS INC                                              | CUSIP: 67080M103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    160937 | NS      | $2687647.90   | 0.52%             |  |  |  | No            |                  1 | On Loan: No      |
| OCUGEN INC                       | OCUGEN INC                                                          | CUSIP: 67577C105<br>LEI: 549300JVNUI9CXWJLR09 | Long             | EC               | CORP              | US        |    304496 | NS      | $526778.08    | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Olema Pharmaceuticals Inc.       | OLEMA PHARMACEUTICALS INC                                           | CUSIP: 68062P106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    141558 | NS      | $2039850.78   | 0.39%             |  |  |  | No            |                  1 | On Loan: No      |
| OMNIAB INC                       | OmniAb Inc. USD0.0001 A (USD12.5 VESTING)                           | CUSIP: 68218J202<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     14783 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| OMNIAB INC                       | OmniAb Inc. USD0.0001 A (USD15 VESTING)                             | CUSIP: 68218J301<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     14783 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| ORIC Pharmaceuticals Inc.        | ORIC PHARMACEUTICALS INC                                            | CUSIP: 68622P109<br>LEI: 54930033FJRNEYBW0L25 | Long             | EC               | CORP              | US        |    124292 | NS      | $1228004.96   | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Oruka Therapeutics Inc           | ORUKA THERAPEUTICS INC                                              | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |     43576 | NS      | $2981034.16   | 0.57%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC Therapeutics, Inc.           | PTC Therapeutics, Inc. COM USD0.001                                 | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |     73928 | NS      | $4809755.68   | 0.93%             |  |  |  | No            |                  1 | On Loan: No      |
| Palvella Therapeutics Inc.       | PALVELLA THERAPEUTICS INC                                           | CUSIP: 697947109<br>LEI: 254900AJDH8PAOOI5T33 | Long             | EC               | CORP              | US        |     15705 | NS      | $2015265.60   | 0.39%             |  |  |  | No            |                  1 | On Loan: —       |
| PRAXIS PRECISION MEDICINES INC   | PRAXIS PRECISION MEDICINES I                                        | CUSIP: 74006W207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     16345 | NS      | $5211276.35   | 1.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Precigen Inc                     | PRECIGEN INC                                                        | CUSIP: 74017N105<br>LEI: 549300XCWNQU35K64G19 | Long             | EC               | CORP              | US        |    343575 | NS      | $1429272.00   | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Prime Medicine Inc               | PRIME MEDICINE INC                                                  | CUSIP: 74168J101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    232034 | NS      | $822560.53    | 0.16%             |  |  |  | No            |                  1 | On Loan: —       |
| Protagonist Therapeutics Inc     | Protagonist Therapeutics Inc COM USD0.00001                         | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     50321 | NS      | $4980269.37   | 0.96%             |  |  |  | No            |                  1 | On Loan: No      |
| RECURSION PHARMACEUTICALS INC    | Recursion Pharmaceuticals Inc CL A                                  | CUSIP: 75629V104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    958574 | NS      | $3316666.04   | 0.64%             |  |  |  | No            |                  1 | On Loan: —       |
| REGENERON PHARMACEUTICALS INC    | Regeneron Pharmaceuticals, Inc. COM USD0.001                        | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |      6267 | NS      | $4431145.02   | 0.85%             |  |  |  | No            |                  1 | On Loan: No      |
| Regenxbio Inc.                   | REGENXBIO INC                                                       | CUSIP: 75901B107<br>LEI: 549300EOES47LATSET33 | Long             | EC               | CORP              | US        |     79519 | NS      | $713285.43    | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Relay Therapeutics Inc           | Relay Therapeutics Inc COM                                          | CUSIP: 75943R102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    162116 | NS      | $2101023.36   | 0.40%             |  |  |  | No            |                  1 | On Loan: —       |
| Replimune Group Inc              | REPLIMUNE GROUP INC                                                 | CUSIP: 76029N106<br>LEI: 549300AY704NEIRC4K64 | Long             | EC               | CORP              | US        |    127521 | NS      | $327728.97    | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Revolution Medicines Inc         | Revolution Medicines Inc COM                                        | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |     48748 | NS      | $7025561.76   | 1.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Rhythm Pharmaceuticals Inc       | Rhythm Pharmaceuticals Inc COM USD0.001                             | CUSIP: 76243J105<br>LEI: 529900JPNWXQ8DPLA551 | Long             | EC               | CORP              | US        |     53930 | NS      | $4387744.80   | 0.85%             |  |  |  | No            |                  1 | On Loan: No      |
| Rigel Pharmaceuticals Inc.       | RIGEL PHARMACEUTICALS INC                                           | CUSIP: 766559702<br>LEI: 529900KPTNUS5J8K9K66 | Long             | EC               | CORP              | US        |     40551 | NS      | $1171923.90   | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| ROCKET PHARMACEUTICALS INC       | ROCKET PHARMACEUTICALS INC                                          | CUSIP: 77313F106<br>LEI: 549300R7VV82YUIN4Y93 | Long             | EC               | CORP              | US        |    151991 | NS      | $528928.68    | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Sana Biotechnology Inc           | SANA BIOTECHNOLOGY INC                                              | CUSIP: 799566104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    380569 | NS      | $1252072.01   | 0.24%             |  |  |  | No            |                  1 | On Loan: —       |
| Sarepta Therapeutics Inc         | Sarepta Therapeutics Inc COM USD0.0001                              | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |    175121 | NS      | $3656526.48   | 0.70%             |  |  |  | No            |                  1 | On Loan: No      |
| Savara Inc                       | SAVARA INC                                                          | CUSIP: 805111101<br>LEI: 5493002JO0WM3YMJXG33 | Long             | EC               | CORP              | US        |    203377 | NS      | $1065695.48   | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Scholar Rock Holding Corp.       | SCHOLAR ROCK HOLDING CORP                                           | CUSIP: 80706P103<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |    112425 | NS      | $5240129.25   | 1.01%             |  |  |  | No            |                  1 | On Loan: No      |
| SELLAS LIFE SCIENCES GROUP INC   | SELLAS LIFE SCIENCES GROUP I                                        | CUSIP: 81642T209<br>LEI: 549300VZIH50VYURLQ98 | Long             | EC               | CORP              | US        |    268465 | NS      | $1328901.75   | 0.26%             |  |  |  | No            |                  1 | On Loan: —       |
| ARS Pharmaceuticals Inc          | ARS PHARMACEUTICALS INC                                             | CUSIP: 82835W108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    126616 | NS      | $1045848.16   | 0.20%             |  |  |  | No            |                  1 | On Loan: —       |
| Sionna Therapeutics Inc.         | SIONNA THERAPEUTICS INC                                             | CUSIP: 829401108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     23827 | NS      | $922104.90    | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Soleno Therapeutics Inc          | SOLENO THERAPEUTICS INC                                             | CUSIP: 834203309<br>LEI: 5493003LCY77N7FXK844 | Long             | EC               | CORP              | US        |     85699 | NS      | $4526621.18   | 0.87%             |  |  |  | No            |                  1 | On Loan: No      |
| Stoke Therapeutics Inc           | STOKE THERAPEUTICS INC                                              | CUSIP: 86150R107<br>LEI: 549300RD25SS2DIJHJ67 | Long             | EC               | CORP              | US        |     64471 | NS      | $2109491.12   | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Summit Therapeutics Inc.         | SUMMIT THERAPEUTICS INC                                             | CUSIP: 86627T108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    278847 | NS      | $5984056.62   | 1.15%             |  |  |  | No            |                  1 | On Loan: —       |
| Syndax Pharmaceuticals Inc.      | Syndax Pharmaceuticals Inc. COM USD0.0001                           | CUSIP: 87164F105<br>LEI: 529900OF94TRHKZVBS87 | Long             | EC               | CORP              | US        |    134242 | NS      | $2876806.06   | 0.55%             |  |  |  | No            |                  1 | On Loan: No      |
| Tango Therapeutics Inc.          | TANGO THERAPEUTICS INC                                              | CUSIP: 87583X109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    112975 | NS      | $2442519.50   | 0.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Taysha Gene Therapies Inc.       | TAYSHA GENE THERAPIES INC                                           | CUSIP: 877619106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    322791 | NS      | $2062634.49   | 0.40%             |  |  |  | No            |                  1 | On Loan: No      |
| TG Therapeutics Inc              | TG Therapeutics Inc COM USD0.001                                    | CUSIP: 88322Q108<br>LEI: 529900X21UKABN9NJ529 | Long             | EC               | CORP              | US        |    173080 | NS      | $5846642.40   | 1.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Travere Therapeutics Inc         | Travere Therapeutics Inc COM                                        | CUSIP: 89422G107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    164067 | NS      | $6910502.04   | 1.33%             |  |  |  | No            |                  1 | On Loan: No      |
| Twist Bioscience Corporation     | Twist Bioscience Corporation COM USD0.00001                         | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |    103603 | NS      | $6055595.35   | 1.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Tyra Biosciences Inc             | TYRA BIOSCIENCES INC                                                | CUSIP: 90240B106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     37514 | NS      | $1303611.50   | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| ULTRAGENYX PHARMACEUTICAL INC    | Ultragenyx Pharmaceuticals Inc COM USD0.001                         | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |    178057 | NS      | $4396227.33   | 0.85%             |  |  |  | No            |                  1 | On Loan: No      |
| United Therapeutics Corporation  | United Therapeutics Corporation COM USD0.01                         | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |      8914 | NS      | $5093013.90   | 0.98%             |  |  |  | No            |                  1 | On Loan: No      |
| VANDA PHARMACEUTICALS INC        | VANDA PHARMACEUTICALS INC                                           | CUSIP: 921659108<br>LEI: 529900AY8VOOQBKJ0O70 | Long             | EC               | CORP              | US        |     99351 | NS      | $705392.10    | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Vaxcyte Inc                      | Vaxcyte Inc COM                                                     | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |     84388 | NS      | $4830369.12   | 0.93%             |  |  |  | No            |                  1 | On Loan: —       |
| Verastem Inc                     | VERASTEM INC                                                        | CUSIP: 92337C203<br>LEI: 549300IY0EFBIU8NQC81 | Long             | EC               | CORP              | US        |    117456 | NS      | $641309.76    | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Veracyte Inc                     | Veracyte Inc COM USD0.001                                           | CUSIP: 92337F107<br>LEI: 529900ESWZRHXOW27Z37 | Long             | EC               | CORP              | US        |    112171 | NS      | $3692669.32   | 0.71%             |  |  |  | No            |                  1 | On Loan: No      |
| Vera Therapeutics Inc.           | VERA THERAPEUTICS INC                                               | CUSIP: 92337R101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    109557 | NS      | $3901324.77   | 0.75%             |  |  |  | No            |                  1 | On Loan: No      |
| Vericel Corporation              | Vericel Corporation COM NPV                                         | CUSIP: 92346J108<br>LEI: 54930076YM3PLTDR4B91 | Long             | EC               | CORP              | US        |     63931 | NS      | $2220323.63   | 0.43%             |  |  |  | No            |                  1 | On Loan: No      |
| VERTEX PHARMACEUTICALS INC       | Vertex Pharmaceuticals Incorporated COM USD0.01                     | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |      9860 | NS      | $4213966.80   | 0.81%             |  |  |  | No            |                  1 | On Loan: No      |
| VERVE THERAPEUTICS INC (CVR)     | VERVE THERAPEUTICS INC (CVR)                                        | CUSIP: 925CVR011<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     82531 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Viking Therapeutics Inc.         | VIKING THERAPEUTICS INC                                             | CUSIP: 92686J106<br>LEI: 529900IVC72YPFA25M37 | Long             | EC               | CORP              | US        |    135757 | NS      | $4232903.26   | 0.82%             |  |  |  | No            |                  1 | On Loan: —       |
| VIR Biotechnology Inc            | VIR Biotechnology Inc COM                                           | CUSIP: 92764N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    144675 | NS      | $1477855.13   | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Viridian Therapeutics Inc        | Viridian Therapeutics Inc COM                                       | CUSIP: 92790C104<br>LEI: 549300C775BNYF550E70 | Long             | EC               | CORP              | US        |    152815 | NS      | $2059946.20   | 0.40%             |  |  |  | No            |                  1 | On Loan: No      |
| VOR BIOPHARMA INC                | VOR BIOPHARMA INC                                                   | CUSIP: 929033207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     54358 | NS      | $778950.14    | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Xencor Inc                       | Xencor Inc COM USD0.01                                              | CUSIP: 98401F105<br>LEI: 549300V5IF65437JKG30 | Long             | EC               | CORP              | US        |     81350 | NS      | $970505.50    | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| ZENAS BIOPHARMA INC              | ZENAS BIOPHARMA INC                                                 | CUSIP: 98937L105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     51847 | NS      | $1001684.04   | 0.19%             |  |  |  | No            |                  1 | On Loan: —       |
| Alkermes PLC                     | Alkermes PLC COM USD0.01                                            | CUSIP: G01767105<br>LEI: N/A                  | Long             | EC               | CORP              | IE        |    174823 | NS      | $5893283.33   | 1.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Biohaven Ltd                     | Biohaven Ltd COM NPV                                                | CUSIP: G1110E107<br>LEI: N/A                  | Long             | EC               | CORP              | VG        |    220160 | NS      | $2111334.40   | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Prothena Corporation PLC         | PROTHENA CORP PLC                                                   | CUSIP: G72800108<br>LEI: 5299009ZXQ8NIIJ8OL30 | Long             | EC               | CORP              | IE        |     57328 | NS      | $634047.68    | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Roivant Sciences Ltd             | ROIVANT SCIENCES LTD                                                | CUSIP: G76279101<br>LEI: 549300DL466NY5J6U724 | Long             | EC               | CORP              | BM        |    164121 | NS      | $4682372.13   | 0.90%             |  |  |  | No            |                  1 | On Loan: No      |
| CRISPR Therapeutics AG           | CRISPR Therapeutics AG COM CHF0.03                                  | CUSIP: H17182108<br>LEI: 506700O6IRRIQLT3W370 | Long             | EC               | CORP              | CH        |     97235 | NS      | $5089279.90   | 0.98%             |  |  |  | No            |                  1 | On Loan: —       |
| Uniqure N.V.                     | UNIQURE NV                                                          | CUSIP: N90064101<br>LEI: 724500RPCTZLFYJZ3S98 | Long             | EC               | CORP              | NL        |     97163 | NS      | $1938401.85   | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| DREYFUS GOVERNMENT CASH MANAGE   | DREYFUS GOV'T CASH MGMT -INSTITUTIONAL CUSIP 262006208 DGCXX (#289) | CUSIP: N/A<br>LEI: N/A                        | Long             | STIV             | RF                | US        |  40990416 | PA      | $40990416.22  | 7.90%             |  |  |  | No            |                  1 | On Loan: No      |
| GOLDMAN FINANCIAL                | GOLDMAN FINL SQ TRSRY INST 506                                      | CUSIP: N/A<br>LEI: 549300DAH6N80PM31E83       | Long             | STIV             | RF                | US        |  34559954 | PA      | $34559954.16  | 6.66%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                              | S&P BIOTECHNOLOGY SELECT INDUSTRY INDEX SWAP                        | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |         1 | NC      | $7889482.91   | 1.52%             |  |  |  | No            |                  2 | On Loan: No      |
| N/A                              | S&P BIOTECHNOLOGY SELECT INDUSTRY INDEX SWAP                        | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |         1 | NC      | $695166.35    | 0.13%             |  |  |  | No            |                  2 | On Loan: No      |
| N/A                              | S&P BIOTECHNOLOGY SELECT INDUSTRY INDEX SWAP                        | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |         1 | NC      | $3213458.15   | 0.62%             |  |  |  | No            |                  2 | On Loan: No      |
| N/A                              | S&P BIOTECHNOLOGY SELECT INDUSTRY INDEX SWAP                        | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |         1 | NC      | $3006936.29   | 0.58%             |  |  |  | No            |                  2 | On Loan: No      |
| N/A                              | S&P BIOTECHNOLOGY SELECT INDUSTRY INDEX SWAP                        | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |         1 | NC      | $5109095.76   | 0.98%             |  |  |  | No            |                  2 | On Loan: No      |
| N/A                              | S&P BIOTECHNOLOGY SELECT INDUSTRY INDEX SWAP                        | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |         1 | NC      | $5716673.63   | 1.10%             |  |  |  | No            |                  2 | On Loan: No      |
| N/A                              | S&P BIOTECHNOLOGY SELECT INDUSTRY INDEX SWAP                        | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |         1 | NC      | $14425305.89  | 2.78%             |  |  |  | No            |                  2 | On Loan: No      |
| DREYFUS                          | DREYFUS TRSRY SECURITIES CASH MGMT                                  | CUSIP: S99991620<br>LEI: N/A                  | Long             | STIV             | RF                | US        |         0 | PA      | $0.00         | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| GOLDMAN SACHS LIQ ES FD A        | GOLDMAN SACHS FIN GOV 465 INSTITUT                                  | CUSIP: N/A<br>LEI: N/A                        | Long             | STIV             | RF                | US        |   9422419 | PA      | $9422418.66   | 1.82%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2026-06-26

**Name of Applicant:** Direxion Shares ETF Trust

**Signature:** Patrick Rudnick

**Name of Signer:** Patrick Rudnick

**Title:** Principal Executive Officer