# EDGAR Filing Document

**Accession Number:** 0001828253
**File Stem:** 0001171843-23-001844
**Filing Date:** 2023-3
**Character Count:** 7885
**Document Hash:** ebaa118dd931b4fea91a06d562fffd79
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001171843-23-001844.hdr.sgml**: 20230323

**ACCESSION NUMBER**: 0001171843-23-001844

**CONFORMED SUBMISSION TYPE**: 6-K

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20230323

**FILED AS OF DATE**: 20230323

**DATE AS OF CHANGE**: 20230323

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Evaxion Biotech A/S
- **CENTRAL INDEX KEY:** 0001828253
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** G7
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 6-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-39950
- **FILM NUMBER:** 23754602

**BUSINESS ADDRESS:**
- **STREET 1:** BREDGADE 34E
- **CITY:** COPENHAGEN K
- **STATE:** G7
- **ZIP:** 1260
- **BUSINESS PHONE:** 4531262615

**MAIL ADDRESS:**
- **STREET 1:** BREDGADE 34E
- **CITY:** COPENHAGEN K
- **STATE:** G7
- **ZIP:** 1260

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**Form 6-K**

**REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934**

**For the month of March 2023**

Commission File Number: **001-39950**

**Evaxion Biotech**

(Translation of registrant's name into English)

**Dr. Neergaards Vej 5f DK-2970 Hoersholm Denmark**

(Address of principal executive office)

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.

Form 20-F [ X ] &nbsp;&nbsp;&nbsp;&nbsp; Form 40-F [ ]

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**INCORPORATION BY REFERENCE**

This report on Form 6-K shall be deemed to be incorporated by reference in Evaxion Biotech A/S's registration statements on Form S-8 (File No. 333-255064), on Form F-3 (File No. 333-265132) and on Form F-1 (File No. 333-266050), including any prospectuses forming a part of such registration statements and to be a part thereof from the date on which this report is filed, to the extent not superseded by documents or reports subsequently filed or furnished.

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On March 23, 2023, the Registrant issued a press release, a copy of which is attached hereto as Exhibit 99.1 and is incorporated herein by reference.

[(c) Exhibit 99.1. Press release dated March 23, 2023](exh_991.htm)

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**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

---

| | |
|:---|:---|
|  | <u>**&nbsp;&nbsp;&nbsp;&nbsp;Evaxion Biotech&nbsp;&nbsp;&nbsp;&nbsp;**</u> |
|  | (Registrant) |
| Date: March 23, 2023 | <u>&nbsp;&nbsp;&nbsp;&nbsp;/s/ Katrine Hertz Mortensen&nbsp;&nbsp;&nbsp;&nbsp;</u> |
|  | Katrine Hertz Mortensen |
|  | VP, Communications |

---

## Exhibit 99.1

**EXHIBIT 99.1**

**Evaxion presents a new source of AI-derived immunotherapeutic targets strongly associated with the overall survival of cancer patients**

* *Evaxion's AI technology has led to the identification of new viral targets for cancer immunotherapy*

* *This potentially enables treatment for patients with cold tumors, normally unresponsive to immunotherapy*

COPENHAGEN, Denmark, March 23, 2023 (GLOBE NEWSWIRE) -- Evaxion Biotech A/S (NASDAQ: EVAX) ("Evaxion" or the "Company"), a clinical-stage biotechnology company specializing in the discovery and development of AI-powered immunotherapies today announces that it has developed a new proprietary AI platform technology ObsERV™ to identify a new source of targets for personalized cancer therapy, potentially enabling treatment of patients that are currently considered unresponsive to cancer immunotherapy.

ObsERV™, Evaxion's new proprietary AI platform technology, identifies patient-specific virus targets, so-called ERVs (endogenous retroviruses), expressed in cancer. Evaxion has demonstrated that overexpression of such ERVs is strongly associated with the overall survival of cancer patients, notably of patients that are normally considered unresponsive to immunotherapy. In addition, the Company has preclinically demonstrated complete tumor eradication in animal models when targeting ERVs.

CEO Per Norlén:

"I am thrilled to share this exciting discovery, which may unlock the treatment of a much larger group of cancer patients. While there are efforts to develop cancer vaccines against ERVs that are shared between small groups of patients, we believe that we are the first in the world to use ERVs as targets for personalized cancer immunotherapy, broadening the scope tremendously."

ERVs are remnants of ancient viruses lying dormant in our genomes. ERVs are often overexpressed in cancers but not in healthy tissue, making them visible to the immune system and hence a promising target for immunotherapy. Evaxion's AI platforms for decoding the immune system have been the key to allowing the identification of patient-specific ERVs.

"Our AI platforms are continuously getting more powerful through machine learning. This ongoing, iterative improvement and the cross-pollination between our platforms for infectious disease and cancer has been essential for developing the new AI platform ObsERV. And it opens up a new treatment paradigm in cancer. Next step will be to turn this discovery into an AI-based drug development program that we intend to bring towards the clinic and to patients," Per Norlén concludes.

Evaxion will publish a preprint next week, and on March 28, Christian Garde, Director of Bioinformatics at Evaxion, will present this data at the Immuno 2023 conference in London, UK (link here).

**For more information, please contact:**

Per Norlén, CEO

pno@evaxion-biotech.com

**or:** 

Katrine Hertz Mortensen

VP, Communications and Public Relations

<u>khm@evaxion-biotech.com</u>

+45 3010 0203

**Forward-Looking Statements**

This announcement contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. The words "target," "believe," "expect," "hope," "aim," "intend," "may," "might," "anticipate," "contemplate," "continue," "estimate," "plan," "potential," "predict," "project," "will," "can have," "likely," "should," "would," "could," and other words and terms of similar meaning identify forward-looking statements. Actual results may differ materially from those indicated by such forward-looking statements as a result of various factors, including, but not limited to, risks related to: our financial condition and need for additional capital; our development work; cost and success of our product development activities and preclinical and clinical trials; commercializing any approved pharmaceutical product developed using our AI platform technology, including the rate and degree of market acceptance of our product candidates; our dependence on third parties including for conduct of clinical testing and product manufacture; our inability to enter into partnerships; government regulation; protection of our intellectual property rights; employee matters and managing growth; our ADSs and ordinary shares, the impact of international economic, political, legal, compliance, social and business factors, including inflation, and the effects on our business from the worldwide COVID-19 pandemic and the ongoing conflict in the region surrounding Ukraine and Russia; and other uncertainties affecting our business operations and financial condition. For a further discussion of these risks, please refer to the risk factors included in our most recent Annual Report on Form 20-F and other filings with the U.S. Securities and Exchange Commission (SEC), which are available at **www.sec.gov**. We do not assume any obligation to update any forward-looking statements except as required by law.