# EDGAR Filing Document

**Accession Number:** 0001837309
**File Stem:** 0001172661-23-001199
**Filing Date:** 2023-2
**Character Count:** 35195
**Document Hash:** 78a96ba2e6a0a1f3fbfaba9d98b3370e
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001172661-23-001199.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001172661-23-001199

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**EFFECTIVENESS DATE**: 20230214

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Polar Capital Holdings Plc
- **CENTRAL INDEX KEY:** 0001837309
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** X0
- **FISCAL YEAR END:** 0331

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-20910
- **FILM NUMBER:** 23626653

**BUSINESS ADDRESS:**
- **STREET 1:** 16 PALACE STREET
- **CITY:** LONDON
- **STATE:** X0
- **ZIP:** SW1E 5JD
- **BUSINESS PHONE:** 02072272700

**MAIL ADDRESS:**
- **STREET 1:** 16 PALACE STREET
- **CITY:** LONDON
- **STATE:** X0
- **ZIP:** SW1E 5JD

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2022

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** Polar Capital Holdings Plc<br>**Address:** 16 Palace Street<br>London, X0 SW1E 5JD

**Form 13F File Number:** 028-20910

**CRD Number (if applicable):** 000136133

**SEC File Number (if applicable):** 801-64644

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Samir Ayub<br>**Title:** Group Finance Director<br>**Phone:** 44-0-20-7227-2700

**Signature, Place, and Date of Signing:**

/s/ Samir Ayub  London, X0  02-14-2023<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 2

**Form 13F Information Table Entry Total:** 309

**Form 13F Information Table Value Total:** $12546434452

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

| No.   | Name                           | Form 13F File Number   |
|:---|:---|:---|
|  | Polar Capital LLP              | 028-13167              |
|  | Polar Capital (Switzerland) AG |  |

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| ABBVIE INC | COM | 00287Y109 |  | 50800003 | 314337 | SH |  | DFND | 1 | 314337 | 0 | 0 |
| ACADIA HEALTHCARE COMPANY IN | COM | 00404A109 |  | 88731329 | 1077883 | SH |  | DFND | 1 | 1077883 | 0 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 |  | 7960000 | 500000 | SH |  | DFND | 1 | 500000 | 0 | 0 |
| ACTIVISION BLIZZARD INC | COM | 00507V109 |  | 29170679 | 381067 | SH |  | DFND | 1 | 381067 | 0 | 0 |
| ADDUS HOMECARE CORP | COM | 006739106 |  | 37797544 | 379913 | SH |  | DFND | 1 | 379913 | 0 | 0 |
| ADICET BIO INC | COM | 007002108 |  | 11298596 | 1263825 | SH |  | DFND | 1 | 1263825 | 0 | 0 |
| ADVANCED MICRO DEVICES INC | COM | 007903107 |  | 245288783 | 3787074 | SH |  | DFND | 1 | 3787074 | 0 | 0 |
| AFFILIATED MANAGERS GROUP IN | COM | 008252108 |  | 20851289 | 131612 | SH |  | DFND | 1 | 131612 | 0 | 0 |
| AFLAC INC | COM | 001055102 |  | 41365500 | 575000 | SH |  | DFND | 1 | 575000 | 0 | 0 |
| AIR PRODS  CHEMS INC | COM | 009158106 |  | 5132529 | 16650 | SH |  | DFND | 12 | 16650 | 0 | 0 |
| AIR TRANS SVCS GROUP INC | NOTE 1.125%10/1 | 00922RAB1 |  | 20425100 | 19615000 | SH |  | DFND | 1 | 19615000 | 0 | 0 |
| AIRBNB INC | COM CL A | 009066101 |  | 54607055 | 638679 | SH |  | DFND | 1 | 638679 | 0 | 0 |
| AKAMAI TECHNOLOGIES INC | NOTE 0.125% 5/0 | 00971TAJ0 |  | 12343500 | 11700000 | SH |  | DFND | 1 | 11700000 | 0 | 0 |
| AKOYA BIOSCIENCES INC | COM | 00974H104 |  | 12589048 | 1315470 | SH |  | DFND | 1 | 1315470 | 0 | 0 |
| ALBEMARLE CORP | COM | 012653101 |  | 574679 | 2650 | SH |  | DFND | 12 | 2650 | 0 | 0 |
| ALCON AG | ORD SHS | H01301128 |  | 23769987 | 346754 | SH |  | DFND | 1 | 346754 | 0 | 0 |
| ALIBABA GROUP HLDG LTD | SPONSORED ADS | 01609W102 |  | 91454686 | 1038196 | SH |  | DFND | 1 | 1038196 | 0 | 0 |
| ALKERMES PLC | SHS | G01767105 |  | 58830179 | 2251442 | SH |  | DFND | 1 | 2251442 | 0 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 |  | 70700875 | 297500 | SH |  | DFND | 1 | 297500 | 0 | 0 |
| ALPHABET INC | CAP STK CL C | 02079K107 |  | 211982359 | 2389072 | SH |  | DFND | 1 | 2389072 | 0 | 0 |
| ALPHABET INC | CAP STK CL A | 02079K305 |  | 186888168 | 2118193 | SH |  | DFND | 1 | 2118193 | 0 | 0 |
| AMAZON COM INC | COM | 023135106 |  | 102220524 | 1216911 | SH |  | DFND | 1 | 1216911 | 0 | 0 |
| AMDOCS LTD | SHS | G02602103 |  | 19107271 | 210201 | SH |  | DFND | 1 | 210201 | 0 | 0 |
| AMETEK INC | COM | 031100100 |  | 17195899 | 123074 | SH |  | DFND | 1 | 123074 | 0 | 0 |
| AMGEN INC | COM | 031162100 |  | 6687077 | 25461 | SH |  | DFND | 1 | 25461 | 0 | 0 |
| ANALOG DEVICES INC | COM | 032654105 |  | 72852448 | 444141 | SH |  | DFND | 12 | 444141 | 0 | 0 |
| AON PLC | SHS CL A | G0403H108 |  | 108050400 | 360000 | SH |  | DFND | 1 | 360000 | 0 | 0 |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 |  | 356799 | 6900 | SH |  | DFND | 1 | 6900 | 0 | 0 |
| APPLE INC | COM | 037833100 |  | 537019790 | 4133147 | SH |  | DFND | 1 | 4133147 | 0 | 0 |
| APTARGROUP INC | COM | 038336103 |  | 14454891 | 131432 | SH |  | DFND | 1 | 131432 | 0 | 0 |
| APTIV PLC | SHS | G6095L109 |  | 586719 | 6300 | SH |  | DFND | 2 | 6300 | 0 | 0 |
| ARCH CAP GROUP LTD | ORD | G0450A105 |  | 319666594 | 5091854 | SH |  | DFND | 1 | 5091854 | 0 | 0 |
| ARCUTIS BIOTHERAPEUTICS INC | COM | 03969K108 |  | 29685500 | 2005777 | SH |  | DFND | 1 | 2005777 | 0 | 0 |
| ARES CAPITAL CORP | COM | 04010L103 |  | 4685248 | 253668 | SH |  | DFND | 1 | 253668 | 0 | 0 |
| ARES MANAGEMENT CORPORATION | CL A COM STK | 03990B101 |  | 4556051 | 66570 | SH |  | DFND | 1 | 66570 | 0 | 0 |
| ARISTA NETWORKS INC | COM | 040413106 |  | 129486518 | 1067050 | SH |  | DFND | 1 | 1067050 | 0 | 0 |
| ARRAY TECHNOLOGIES INC | NOTE 1.000%12/0 | 04271TAB6 |  | 10981125 | 10750000 | SH |  | DFND | 1 | 10750000 | 0 | 0 |
| ARRAY TECHNOLOGIES INC | COM SHS | 04271T100 |  | 3063805 | 158500 | SH |  | DFND | 12 | 158500 | 0 | 0 |
| ARROWHEAD PHARMACEUTICALS IN | COM | 04280A100 |  | 508906 | 12547 | SH |  | DFND | 1 | 12547 | 0 | 0 |
| ASPEN TECHNOLOGY INC | COM | 29109X106 |  | 1906523 | 9282 | SH |  | DFND | 1 | 9282 | 0 | 0 |
| ATLASSIAN CORPORATION | CL A | 049468101 |  | 39199917 | 304631 | SH |  | DFND | 1 | 304631 | 0 | 0 |
| ATRICURE INC | COM | 04963C209 |  | 816548 | 18399 | SH |  | DFND | 1 | 18399 | 0 | 0 |
| AVADEL PHARMACEUTICALS PLC | SPONSORED ADR | 05337M104 |  | 20137428 | 2812490 | SH |  | DFND | 1 | 2812490 | 0 | 0 |
| AVANTOR INC | COM | 05352A100 |  | 44307580 | 2100881 | SH |  | DFND | 1 | 2100881 | 0 | 0 |
| AXON ENTERPRISE INC | COM | 05464C101 |  | 6131114 | 36950 | SH |  | DFND | 1 | 36950 | 0 | 0 |
| AXONICS INC | COM | 05465P101 |  | 44417310 | 710336 | SH |  | DFND | 1 | 710336 | 0 | 0 |
| AZENTA INC | COM | 114340102 |  | 322539 | 5540 | SH |  | DFND | 1 | 5540 | 0 | 0 |
| BAKER HUGHES COMPANY | CL A | 05722G100 |  | 11460563 | 388099 | SH |  | DFND | 1 | 388099 | 0 | 0 |
| BANK AMERICA CORP | COM | 060505104 |  | 27170224 | 820357 | SH |  | DFND | 1 | 820357 | 0 | 0 |
| BANK OF NT BUTTERFIELD L | SHS NEW | G0772R208 |  | 4553984 | 152767 | SH |  | DFND | 1 | 152767 | 0 | 0 |
| BECTON DICKINSON  CO | COM | 075887109 |  | 62961120 | 247586 | SH |  | DFND | 1 | 247586 | 0 | 0 |
| BELLUS HEALTH INC NEW | COM NEW | 07987C204 |  | 24965990 | 3037225 | SH |  | DFND | 1 | 3037225 | 0 | 0 |
| BENTLEY SYS INC | NOTE 0.375% 7/0 | 08265TAD1 |  | 6142500 | 7500000 | SH |  | DFND | 1 | 7500000 | 0 | 0 |
| BERKLEY W R CORP | COM | 084423102 |  | 136975875 | 1887500 | SH |  | DFND | 1 | 1887500 | 0 | 0 |
| BERKSHIRE HATHAWAY INC DEL | CL B NEW | 084670702 |  | 98768304 | 319742 | SH |  | DFND | 1 | 319742 | 0 | 0 |
| BICYCLE THERAPEUTICS PLC | SPONSORED ADS | 088786108 |  | 22200000 | 750000 | SH |  | DFND | 1 | 750000 | 0 | 0 |
| BILL COM HLDGS INC | COM | 090043100 |  | 62271076 | 571504 | SH |  | DFND | 1 | 571504 | 0 | 0 |
| BIO RAD LABS INC | CL A | 090572207 |  | 46272402 | 110044 | SH |  | DFND | 1 | 110044 | 0 | 0 |
| BIOGEN INC | COM | 09062X103 |  | 41538000 | 150000 | SH |  | DFND | 1 | 150000 | 0 | 0 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 |  | 18110750 | 175000 | SH |  | DFND | 1 | 175000 | 0 | 0 |
| BIOMARIN PHARMACEUTICAL INC | NOTE 0.599% 8/0 | 09061GAH4 |  | 18297360 | 17200000 | SH |  | DFND | 1 | 17200000 | 0 | 0 |
| BIOMEA FUSION INC | COM | 09077A106 |  | 4215000 | 500000 | SH |  | DFND | 1 | 500000 | 0 | 0 |
| BLACKLINE INC | NOTE 3/1 | 09239BAD1 |  | 31275938 | 36500000 | SH |  | DFND | 1 | 36500000 | 0 | 0 |
| BLOCK INC | CL A | 852234103 |  | 49432960 | 786648 | SH |  | DFND | 1 | 786648 | 0 | 0 |
| BLOOMIN BRANDS INC | NOTE 5.000% 5/0 | 094235AB4 |  | 3655000 | 2000000 | SH |  | DFND | 1 | 2000000 | 0 | 0 |
| BOOKING HOLDINGS INC | COM | 09857L108 |  | 15846147 | 7863 | SH |  | DFND | 1 | 7863 | 0 | 0 |
| BOOKING HOLDINGS INC | NOTE 0.750% 5/0 | 09857LAN8 |  | 6684520 | 5000000 | SH |  | DFND | 1 | 5000000 | 0 | 0 |
| BOSTON SCIENTIFIC CORP | COM | 101137107 |  | 102440993 | 2213983 | SH |  | DFND | 1 | 2213983 | 0 | 0 |
| BRAZE INC | COM CL A | 10576N102 |  | 3295806 | 120814 | SH |  | DFND | 1 | 120814 | 0 | 0 |
| BRUKER CORP | COM | 116794108 |  | 305866 | 4475 | SH |  | DFND | 1 | 4475 | 0 | 0 |
| CANADIAN NAT RES LTD | COM | 136385101 |  | 21922133 | 394780 | SH |  | DFND | 1 | 394780 | 0 | 0 |
| CANNAE HLDGS INC | COM | 13765N107 |  | 15574519 | 754214 | SH |  | DFND | 1 | 754214 | 0 | 0 |
| CASTLE BIOSCIENCES INC | COM | 14843C105 |  | 315389 | 13398 | SH |  | DFND | 1 | 13398 | 0 | 0 |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 |  | 69083500 | 1550000 | SH |  | DFND | 1 | 1550000 | 0 | 0 |
| CENOVUS ENERGY INC | COM | 15135U109 |  | 22375769 | 1138716 | SH |  | DFND | 1 | 1138716 | 0 | 0 |
| CENTENE CORP DEL | COM | 15135B101 |  | 21348597 | 260317 | SH |  | DFND | 1 | 260317 | 0 | 0 |
| CEREVEL THERAPEUTICS HLDNG I | COM | 15678U128 |  | 14865275 | 471315 | SH |  | DFND | 1 | 471315 | 0 | 0 |
| CERIDIAN HCM HLDG INC | NOTE 0.250% 3/1 | 15677JAD0 |  | 11459500 | 13000000 | SH |  | DFND | 1 | 13000000 | 0 | 0 |
| CERUS CORP | COM | 157085101 |  | 7421676 | 2033336 | SH |  | DFND | 1 | 2033336 | 0 | 0 |
| CHART INDS INC | 6.75DP CNV PFD B | 16115Q407 |  | 3798000 | 75000 | SH |  | DFND | 1 | 75000 | 0 | 0 |
| CHEGG INC | NOTE 9/0 | 163092AF6 |  | 15888000 | 20000000 | SH |  | DFND | 1 | 20000000 | 0 | 0 |
| CHEMED CORP NEW | COM | 16359R103 |  | 5359515 | 10500 | SH |  | DFND | 1 | 10500 | 0 | 0 |
| CHUBB LIMITED | COM | H1467J104 |  | 242841113 | 1100821 | SH |  | DFND | 1 | 1100821 | 0 | 0 |
| CITIZENS FINL GROUP INC | COM | 174610105 |  | 8491243 | 215678 | SH |  | DFND | 1 | 215678 | 0 | 0 |
| CLOUDFLARE INC | CL A COM | 18915M107 |  | 61284687 | 1355556 | SH |  | DFND | 1 | 1355556 | 0 | 0 |
| CLOUDFLARE INC | NOTE 8/1 | 18915MAC1 |  | 29110000 | 35500000 | SH |  | DFND | 1 | 35500000 | 0 | 0 |
| COGNEX CORP | COM | 192422103 |  | 7878724 | 167241 | SH |  | DFND | 12 | 167241 | 0 | 0 |
| COMERICA INC | COM | 200340107 |  | 4174315 | 62443 | SH |  | DFND | 1 | 62443 | 0 | 0 |
| CONFLUENT INC | CLASS A COM | 20717M103 |  | 16064352 | 722318 | SH |  | DFND | 1 | 722318 | 0 | 0 |
| COUPA SOFTWARE INC | NOTE 0.125% 6/1 | 22266LAC0 |  | 27682050 | 28500000 | SH |  | DFND | 1 | 28500000 | 0 | 0 |
| CROWDSTRIKE HLDGS INC | CL A | 22788C105 |  | 89352779 | 848635 | SH |  | DFND | 1 | 848635 | 0 | 0 |
| CULLEN FROST BANKERS INC | COM | 229899109 |  | 5333159 | 39889 | SH |  | DFND | 1 | 39889 | 0 | 0 |
| CYBERARK SOFTWARE LTD | SHS | M2682V108 |  | 96009326 | 740527 | SH |  | DFND | 1 | 740527 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 124849282 | 2724777 | SH |  | DFND | 1 | 2724777 | 0 | 0 |
| DATADOG INC | CL A COM | 23804L103 |  | 5732706 | 77996 | SH |  | DFND | 1 | 77996 | 0 | 0 |
| DATADOG INC | NOTE 0.125% 6/1 | 23804LAB9 |  | 4604250 | 4200000 | SH |  | DFND | 1 | 4200000 | 0 | 0 |
| DAY ONE BIOPHARMACEUTICALS I | COM | 23954D109 |  | 30118273 | 1399548 | SH |  | DFND | 1 | 1399548 | 0 | 0 |
| DECIPHERA PHARMACEUTICALS IN | COM | 24344T101 |  | 20487500 | 1250000 | SH |  | DFND | 1 | 1250000 | 0 | 0 |
| DEERE  CO | COM | 244199105 |  | 5940041 | 13854 | SH |  | DFND | 1 | 13854 | 0 | 0 |
| DEXCOM INC | COM | 252131107 |  | 72515046 | 640366 | SH |  | DFND | 1 | 640366 | 0 | 0 |
| DEXCOM INC | NOTE 0.250%11/1 | 252131AK3 |  | 1638750 | 1500000 | SH |  | DFND | 1 | 1500000 | 0 | 0 |
| DROPBOX INC | NOTE 3/0 | 26210CAD6 |  | 8960000 | 10000000 | SH |  | DFND | 1 | 10000000 | 0 | 0 |
| EAST WEST BANCORP INC | COM | 27579R104 |  | 5263565 | 79872 | SH |  | DFND | 1 | 79872 | 0 | 0 |
| EDWARDS LIFESCIENCES CORP | COM | 28176E108 |  | 5675060 | 76063 | SH |  | DFND | 1 | 76063 | 0 | 0 |
| ELASTIC N V | ORD SHS | N14506104 |  | 56323130 | 1093653 | SH |  | DFND | 1 | 1093653 | 0 | 0 |
| ELEVANCE HEALTH INC | COM | 036752103 |  | 20691158 | 40336 | SH |  | DFND | 1 | 40336 | 0 | 0 |
| EMERSON ELEC CO | COM | 291011104 |  | 14551841 | 151487 | SH |  | DFND | 1 | 151487 | 0 | 0 |
| ENCORE CAP EUROPE FIN LTD | NOTE 4.500% 9/0 | 29260UAA5 |  | 2664000 | 2250000 | SH |  | DFND | 1 | 2250000 | 0 | 0 |
| ENERSYS | COM | 29275Y102 |  | 2325960 | 31500 | SH |  | DFND | 12 | 31500 | 0 | 0 |
| ENPHASE ENERGY INC | COM | 29355A107 |  | 64339177 | 242826 | SH |  | DFND | 12 | 242826 | 0 | 0 |
| ENTERPRISE FINL SVCS CORP | COM | 293712105 |  | 5254289 | 107318 | SH |  | DFND | 1 | 107318 | 0 | 0 |
| ENVISTA HOLDINGS CORPORATION | COM | 29415F104 |  | 7786423 | 231257 | SH |  | DFND | 1 | 231257 | 0 | 0 |
| ESQUIRE FINL HLDGS INC | COM | 29667J101 |  | 537981 | 12436 | SH |  | DFND | 1 | 12436 | 0 | 0 |
| ESSENT GROUP LTD | COM | G3198U102 |  | 125874000 | 3237500 | SH |  | DFND | 1 | 3237500 | 0 | 0 |
| ETSY INC | NOTE 0.125%10/0 | 29786AAJ5 |  | 5733150 | 3700000 | SH |  | DFND | 1 | 3700000 | 0 | 0 |
| EVEREST RE GROUP LTD | COM | G3223R108 |  | 96068300 | 290000 | SH |  | DFND | 1 | 290000 | 0 | 0 |
| EVOLENT HEALTH INC | CL A | 30050B101 |  | 1310578 | 46673 | SH |  | DFND | 1 | 46673 | 0 | 0 |
| EXACT SCIENCES CORP | COM | 30063P105 |  | 214626 | 4335 | SH |  | DFND | 1 | 4335 | 0 | 0 |
| EXELIXIS INC | COM | 30161Q104 |  | 41237204 | 2570898 | SH |  | DFND | 1 | 2570898 | 0 | 0 |
| FARFETCH LTD | ORD SH CL A | 30744W107 |  | 3477983 | 735303 | SH |  | DFND | 1 | 735303 | 0 | 0 |
| FERGUSON PLC NEW | SHS | G3421J106 |  | 25173707 | 198265 | SH |  | DFND | 1 | 198265 | 0 | 0 |
| FIRST AMERN FINL CORP | COM | 31847R102 |  | 54957000 | 1050000 | SH |  | DFND | 1 | 1050000 | 0 | 0 |
| FIRST REP BK SAN FRANCISCO C | COM | 33616C100 |  | 15778782 | 129451 | SH |  | DFND | 1 | 129451 | 0 | 0 |
| FIRST SOLAR INC | COM | 336433107 |  | 26857347 | 179300 | SH |  | DFND | 12 | 179300 | 0 | 0 |
| FISERV INC | COM | 337738108 |  | 19834482 | 196245 | SH |  | DFND | 1 | 196245 | 0 | 0 |
| FLYWIRE CORPORATION | COM VTG | 302492103 |  | 15426035 | 630406 | SH |  | DFND | 1 | 630406 | 0 | 0 |
| FRESHWORKS INC | CLASS A COM | 358054104 |  | 42565327 | 2893632 | SH |  | DFND | 1 | 2893632 | 0 | 0 |
| GITLAB INC | CLASS A COM | 37637K108 |  | 68160227 | 1500005 | SH |  | DFND | 1 | 1500005 | 0 | 0 |
| GLOBANT S A | COM | L44385109 |  | 50829387 | 302268 | SH |  | DFND | 1 | 302268 | 0 | 0 |
| GLOBUS MED INC | CL A | 379577208 |  | 53730929 | 723454 | SH |  | DFND | 1 | 723454 | 0 | 0 |
| GOLUB CAP BDC INC | COM | 38173M102 |  | 3730005 | 283435 | SH |  | DFND | 1 | 283435 | 0 | 0 |
| GUARDANT HEALTH INC | NOTE 11/1 | 40131MAB5 |  | 11440925 | 18250000 | SH |  | DFND | 1 | 18250000 | 0 | 0 |
| H WORLD GROUP LTD | SPONSORED ADS | 44332N106 |  | 479176 | 11296 | SH |  | DFND | 1 | 11296 | 0 | 0 |
| H WORLD GROUP LTD | NOTE 3.000% 5/0 | 44332NAB2 |  | 6127500 | 5000000 | SH |  | DFND | 1 | 5000000 | 0 | 0 |
| HAGERTY INC | CL A COM | 405166109 |  | 38066831 | 4526377 | SH |  | DFND | 1 | 4526377 | 0 | 0 |
| HALOZYME THERAPEUTICS INC | NOTE 0.250% 3/0 | 40637HAD1 |  | 2432813 | 2500000 | SH |  | DFND | 1 | 2500000 | 0 | 0 |
| HARMONY BIOSCIENCES HLDGS IN | COM | 413197104 |  | 29441308 | 534325 | SH |  | DFND | 1 | 534325 | 0 | 0 |
| HASHICORP INC | COM CL A | 418100103 |  | 4522009 | 165399 | SH |  | DFND | 1 | 165399 | 0 | 0 |
| HCA HEALTHCARE INC | COM | 40412C101 |  | 20219989 | 84264 | SH |  | DFND | 1 | 84264 | 0 | 0 |
| HEALTH CATALYST INC | COM | 42225T107 |  | 283183 | 26640 | SH |  | DFND | 1 | 26640 | 0 | 0 |
| HUBSPOT INC | COM | 443573100 |  | 130193215 | 450293 | SH |  | DFND | 1 | 450293 | 0 | 0 |
| HUMANA INC | COM | 444859102 |  | 11426447 | 22309 | SH |  | DFND | 1 | 22309 | 0 | 0 |
| ICON PLC | SHS | G4705A100 |  | 17186075 | 88474 | SH |  | DFND | 1 | 88474 | 0 | 0 |
| IMPINJ INC | COM | 453204109 |  | 5264878 | 48222 | SH |  | DFND | 1 | 48222 | 0 | 0 |
| INCYTE CORP | COM | 45337C102 |  | 99200983 | 1235072 | SH |  | DFND | 1 | 1235072 | 0 | 0 |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 |  | 1149539 | 2071242 | SH |  | DFND | 1 | 2071242 | 0 | 0 |
| INSMED INC | COM PAR $.01 | 457669307 |  | 30796153 | 1541349 | SH |  | DFND | 1 | 1541349 | 0 | 0 |
| INSULET CORP | COM | 45784P101 |  | 3711080 | 12606 | SH |  | DFND | 1 | 12606 | 0 | 0 |
| INTERCONTINENTAL EXCHANGE IN | COM | 45866F104 |  | 20882605 | 203554 | SH |  | DFND | 1 | 203554 | 0 | 0 |
| INTRA-CELLULAR THERAPIES INC | COM | 46116X101 |  | 23738854 | 448580 | SH |  | DFND | 1 | 448580 | 0 | 0 |
| INTUIT | COM | 461202103 |  | 15874727 | 40786 | SH |  | DFND | 1 | 40786 | 0 | 0 |
| INTUITIVE SURGICAL INC | COM NEW | 46120E602 |  | 68357079 | 257611 | SH |  | DFND | 1 | 257611 | 0 | 0 |
| IRHYTHM TECHNOLOGIES INC | COM | 450056106 |  | 538603 | 5750 | SH |  | DFND | 1 | 5750 | 0 | 0 |
| ITRON INC | COM | 465741106 |  | 3190950 | 63000 | SH |  | DFND | 12 | 63000 | 0 | 0 |
| IVERIC BIO INC | COM | 46583P102 |  | 40007325 | 1868628 | SH |  | DFND | 1 | 1868628 | 0 | 0 |
| JAMES RIV GROUP LTD | COM | G5005R107 |  | 24569250 | 1175000 | SH |  | DFND | 1 | 1175000 | 0 | 0 |
| JD.COM INC | SPON ADR CL A | 47215P106 |  | 483055 | 8606 | SH |  | DFND | 1 | 8606 | 0 | 0 |
| JOHNSON  JOHNSON | COM | 478160104 |  | 63803507 | 361186 | SH |  | DFND | 1 | 361186 | 0 | 0 |
| JPMORGAN CHASE  CO | COM | 46625H100 |  | 34325979 | 255973 | SH |  | DFND | 1 | 255973 | 0 | 0 |
| KE HLDGS INC | SPONSORED ADS | 482497104 |  | 260508 | 18661 | SH |  | DFND | 1 | 18661 | 0 | 0 |
| KLA CORP | COM NEW | 482480100 |  | 160267158 | 425078 | SH |  | DFND | 1 | 425078 | 0 | 0 |
| KORNIT DIGITAL LTD | SHS | M6372Q113 |  | 20606203 | 897092 | SH |  | DFND | 1 | 897092 | 0 | 0 |
| LANTHEUS HLDGS INC | COM | 516544103 |  | 757011 | 14855 | SH |  | DFND | 1 | 14855 | 0 | 0 |
| LATTICE SEMICONDUCTOR CORP | COM | 518415104 |  | 129516765 | 1996251 | SH |  | DFND | 12 | 1996251 | 0 | 0 |
| LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 |  | 52958481 | 1060867 | SH |  | DFND | 1 | 1060867 | 0 | 0 |
| LIBERTY MEDIA CORP DEL | COM SER C FRMLA | 531229854 |  | 8980570 | 150227 | SH |  | DFND | 1 | 150227 | 0 | 0 |
| LILLY ELI  CO | COM | 532457108 |  | 55627070 | 152053 | SH |  | DFND | 1 | 152053 | 0 | 0 |
| LINDE PLC | SHS | G5494J103 |  | 24732925 | 75826 | SH |  | DFND | 12 | 75826 | 0 | 0 |
| LITTELFUSE INC | COM | 537008104 |  | 8300219 | 37694 | SH |  | DFND | 1 | 37694 | 0 | 0 |
| LIVANOVA PLC | SHS | G5509L101 |  | 38422516 | 691799 | SH |  | DFND | 1 | 691799 | 0 | 0 |
| LIVENT CORP | COM | 53814L108 |  | 366602 | 18450 | SH |  | DFND | 12 | 18450 | 0 | 0 |
| LPL FINL HLDGS INC | COM | 50212V100 |  | 10469762 | 48433 | SH |  | DFND | 1 | 48433 | 0 | 0 |
| MACOM TECH SOLUTIONS HLDGS I | NOTE 0.250% 3/1 | 55405YAB6 |  | 3978000 | 4000000 | SH |  | DFND | 1 | 4000000 | 0 | 0 |
| MARKEL CORP | COM | 570535104 |  | 167979975 | 127500 | SH |  | DFND | 1 | 127500 | 0 | 0 |
| MARRIOTT VACATIONS WORLDWIDE | NOTE 1/1 | 57164YAD9 |  | 3430000 | 3500000 | SH |  | DFND | 1 | 3500000 | 0 | 0 |
| MARSH  MCLENNAN COS INC | COM | 571748102 |  | 220467349 | 1332290 | SH |  | DFND | 1 | 1332290 | 0 | 0 |
| MARVELL TECHNOLOGY INC | COM | 573874104 |  | 94213351 | 2543557 | SH |  | DFND | 12 | 2543557 | 0 | 0 |
| MASTERCARD INCORPORATED | CL A | 57636Q104 |  | 116406095 | 334760 | SH |  | DFND | 1 | 334760 | 0 | 0 |
| MAXEON SOLAR TECHNOLOGIES LT | SHS | Y58473102 |  | 754820 | 47000 | SH |  | DFND | 12 | 47000 | 0 | 0 |
| MERCADOLIBRE INC | COM | 58733R102 |  | 91041884 | 107584 | SH |  | DFND | 1 | 107584 | 0 | 0 |
| MERIT MED SYS INC | COM | 589889104 |  | 39776786 | 563251 | SH |  | DFND | 1 | 563251 | 0 | 0 |
| MERUS N V | COM | N5749R100 |  | 11602500 | 750000 | SH |  | DFND | 1 | 750000 | 0 | 0 |
| META PLATFORMS INC | CL A | 30303M102 |  | 58423385 | 485486 | SH |  | DFND | 1 | 485486 | 0 | 0 |
| MICRON TECHNOLOGY INC | COM | 595112103 |  | 8413583 | 168339 | SH |  | DFND | 1 | 168339 | 0 | 0 |
| MICROSOFT CORP | COM | 594918104 |  | 724694311 | 3021826 | SH |  | DFND | 1 | 3021826 | 0 | 0 |
| MIDDLEBY CORP | NOTE 1.000% 9/0 | 596278AB7 |  | 1770750 | 1500000 | SH |  | DFND | 1 | 1500000 | 0 | 0 |
| MIRUM PHARMACEUTICALS INC | COM | 604749101 |  | 16670687 | 854907 | SH |  | DFND | 1 | 854907 | 0 | 0 |
| MKS INSTRS INC | COM | 55306N104 |  | 9537802 | 112567 | SH |  | DFND | 1 | 112567 | 0 | 0 |
| MOLINA HEALTHCARE INC | COM | 60855R100 |  | 66679013 | 201923 | SH |  | DFND | 1 | 201923 | 0 | 0 |
| MONGODB INC | CL A | 60937P106 |  | 51329179 | 260766 | SH |  | DFND | 1 | 260766 | 0 | 0 |
| MONOLITHIC PWR SYS INC | COM | 609839105 |  | 105064603 | 297120 | SH |  | DFND | 12 | 297120 | 0 | 0 |
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 |  | 9201959 | 876377 | SH |  | DFND | 1 | 876377 | 0 | 0 |
| MORGAN STANLEY | COM NEW | 617446448 |  | 8529036 | 100318 | SH |  | DFND | 1 | 100318 | 0 | 0 |
| MORPHIC HLDG INC | COM | 61775R105 |  | 8693750 | 325000 | SH |  | DFND | 1 | 325000 | 0 | 0 |
| MP MATERIALS CORP | COM CL A | 553368101 |  | 6968360 | 287000 | SH |  | DFND | 12 | 287000 | 0 | 0 |
| MSCI INC | COM | 55354G100 |  | 11425040 | 24561 | SH |  | DFND | 1 | 24561 | 0 | 0 |
| NANOSTRING TECHNOLOGIES INC | COM | 63009R109 |  | 30116486 | 3778731 | SH |  | DFND | 1 | 3778731 | 0 | 0 |
| NATERA INC | COM | 632307104 |  | 1013007 | 25218 | SH |  | DFND | 1 | 25218 | 0 | 0 |
| NCL CORP LTD | NOTE 5.375% 8/0 | 62886HAX9 |  | 5776950 | 5700000 | SH |  | DFND | 1 | 5700000 | 0 | 0 |
| NETEASE INC | SPONSORED ADS | 64110W102 |  | 273670 | 3768 | SH |  | DFND | 1 | 3768 | 0 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 |  | 20776110 | 173946 | SH |  | DFND | 1 | 173946 | 0 | 0 |
| NORFOLK SOUTHN CORP | COM | 655844108 |  | 15026938 | 60981 | SH |  | DFND | 1 | 60981 | 0 | 0 |
| NUTANIX INC | NOTE 0.250%10/0 | 67059NAH1 |  | 30302415 | 36010000 | SH |  | DFND | 1 | 36010000 | 0 | 0 |
| NVIDIA CORPORATION | COM | 67066G104 |  | 189483955 | 1296592 | SH |  | DFND | 1 | 1296592 | 0 | 0 |
| NXP SEMICONDUCTORS N V | COM | N6596X109 |  | 521499 | 3300 | SH |  | DFND | 2 | 3300 | 0 | 0 |
| OMNICELL COM | COM | 68213N109 |  | 672704 | 13342 | SH |  | DFND | 1 | 13342 | 0 | 0 |
| ON SEMICONDUCTOR CORP | COM | 682189105 |  | 38765325 | 621538 | SH |  | DFND | 12 | 621538 | 0 | 0 |
| OPTION CARE HEALTH INC | COM NEW | 68404L201 |  | 69487168 | 2309311 | SH |  | DFND | 1 | 2309311 | 0 | 0 |
| ORGANON  CO | COMMON STOCK | 68622V106 |  | 588150 | 21058 | SH |  | DFND | 1 | 21058 | 0 | 0 |
| OVINTIV INC | COM | 69047Q102 |  | 23629947 | 465982 | SH |  | DFND | 1 | 465982 | 0 | 0 |
| PACIRA BIOSCIENCES INC | COM | 695127100 |  | 486293 | 12595 | SH |  | DFND | 1 | 12595 | 0 | 0 |
| PALO ALTO NETWORKS INC | COM | 697435105 |  | 81176697 | 581745 | SH |  | DFND | 1 | 581745 | 0 | 0 |
| PAYCOM SOFTWARE INC | COM | 70432V102 |  | 6107832 | 19683 | SH |  | DFND | 1 | 19683 | 0 | 0 |
| PAYPAL HLDGS INC | COM | 70450Y103 |  | 278969 | 3917 | SH |  | DFND | 1 | 3917 | 0 | 0 |
| PENUMBRA INC | COM | 70975L107 |  | 79398866 | 356913 | SH |  | DFND | 1 | 356913 | 0 | 0 |
| PINTEREST INC | CL A | 72352L106 |  | 54976111 | 2264255 | SH |  | DFND | 1 | 2264255 | 0 | 0 |
| PLIANT THERAPEUTICS INC | COM | 729139105 |  | 31569060 | 1633164 | SH |  | DFND | 1 | 1633164 | 0 | 0 |
| PLUG POWER INC | COM NEW | 72919P202 |  | 2894580 | 234000 | SH |  | DFND | 12 | 234000 | 0 | 0 |
| PNC FINL SVCS GROUP INC | COM | 693475105 |  | 13800165 | 87376 | SH |  | DFND | 1 | 87376 | 0 | 0 |
| POWER INTEGRATIONS INC | COM | 739276103 |  | 34488785 | 480881 | SH |  | DFND | 12 | 480881 | 0 | 0 |
| PRIVIA HEALTH GROUP INC | COM | 74276R102 |  | 585123 | 25765 | SH |  | DFND | 1 | 25765 | 0 | 0 |
| PROASSURANCE CORP | COM | 74267C106 |  | 39307500 | 2250000 | SH |  | DFND | 1 | 2250000 | 0 | 0 |
| PROGRESSIVE CORP | COM | 743315103 |  | 87554250 | 675000 | SH |  | DFND | 1 | 675000 | 0 | 0 |
| PROGYNY INC | COM | 74340E103 |  | 453482 | 14558 | SH |  | DFND | 1 | 14558 | 0 | 0 |
| PURE STORAGE INC | CL A | 74624M102 |  | 84420280 | 3154719 | SH |  | DFND | 1 | 3154719 | 0 | 0 |
| QIAGEN NV | SHS NEW | N72482123 |  | 18364079 | 368239 | SH |  | DFND | 1 | 368239 | 0 | 0 |
| QORVO INC | COM | 74736K101 |  | 6943024 | 76600 | SH |  | DFND | 12 | 76600 | 0 | 0 |
| QUALCOMM INC | COM | 747525103 |  | 100469878 | 913861 | SH |  | DFND | 1 | 913861 | 0 | 0 |
| QUALTRICS INTL INC | COM CL A | 747601201 |  | 5016270 | 483263 | SH |  | DFND | 1 | 483263 | 0 | 0 |
| QUIDELORTHO CORP | COM | 219798105 |  | 588981 | 6875 | SH |  | DFND | 1 | 6875 | 0 | 0 |
| R1 RCM INC | COM | 77634L105 |  | 9737901 | 889306 | SH |  | DFND | 1 | 889306 | 0 | 0 |
| REGENERON PHARMACEUTICALS | COM | 75886F107 |  | 84775075 | 117500 | SH |  | DFND | 1 | 117500 | 0 | 0 |
| REGIONS FINANCIAL CORP NEW | COM | 7591EP100 |  | 4563842 | 211681 | SH |  | DFND | 1 | 211681 | 0 | 0 |
| REINSURANCE GRP OF AMERICA I | COM NEW | 759351604 |  | 104791375 | 737500 | SH |  | DFND | 1 | 737500 | 0 | 0 |
| RENAISSANCERE HLDGS LTD | COM | G7496G103 |  | 202297805 | 1098072 | SH |  | DFND | 1 | 1098072 | 0 | 0 |
| REPLIGEN CORP | COM | 759916109 |  | 423275 | 2500 | SH |  | DFND | 1 | 2500 | 0 | 0 |
| REVANCE THERAPEUTICS INC | COM | 761330109 |  | 89505765 | 4848633 | SH |  | DFND | 1 | 4848633 | 0 | 0 |
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 |  | 36400000 | 1250000 | SH |  | DFND | 1 | 1250000 | 0 | 0 |
| RLI CORP | COM | 749607107 |  | 36755600 | 280000 | SH |  | DFND | 1 | 280000 | 0 | 0 |
| ROBLOX CORP | CL A | 771049103 |  | 29623672 | 1040888 | SH |  | DFND | 1 | 1040888 | 0 | 0 |
| ROCKWELL AUTOMATION INC | COM | 773903109 |  | 5076190 | 19708 | SH |  | DFND | 1 | 19708 | 0 | 0 |
| ROYAL BK CDA SUSTAINABL | COM | 780087102 |  | 6664608 | 70885 | SH |  | DFND | 1 | 70885 | 0 | 0 |
| RYAN SPECIALTY HOLDINGS INC | CL A | 78351F107 |  | 57076250 | 1375000 | SH |  | DFND | 1 | 1375000 | 0 | 0 |
| S GLOBAL INC | COM | 78409V104 |  | 6172274 | 18428 | SH |  | DFND | 1 | 18428 | 0 | 0 |
| SABRE CORP | COM | 78573M104 |  | 6435067 | 1041273 | SH |  | DFND | 1 | 1041273 | 0 | 0 |
| SALESFORCE INC | COM | 79466L302 |  | 59352853 | 447642 | SH |  | DFND | 1 | 447642 | 0 | 0 |
| SANOFI | SPONSORED ADR | 80105N105 |  | 54483750 | 1125000 | SH |  | DFND | 1 | 1125000 | 0 | 0 |
| SAREPTA THERAPEUTICS INC | DEBT 1.250% 9/1 | 803607AC4 |  | 10996250 | 9500000 | SH |  | DFND | 1 | 9500000 | 0 | 0 |
| SCHWAB CHARLES CORP | COM | 808513105 |  | 9572819 | 114975 | SH |  | DFND | 1 | 114975 | 0 | 0 |
| SEA LTD | SPONSORD ADS | 81141R100 |  | 24468877 | 470284 | SH |  | DFND | 1 | 470284 | 0 | 0 |
| SEA LTD | NOTE 2.375%12/0 | 81141RAF7 |  | 5131880 | 5200000 | SH |  | DFND | 1 | 5200000 | 0 | 0 |
| SEAGEN INC | COM | 81181C104 |  | 106101968 | 825632 | SH |  | DFND | 1 | 825632 | 0 | 0 |
| SERVICE CORP INTL | COM | 817565104 |  | 12290672 | 177765 | SH |  | DFND | 1 | 177765 | 0 | 0 |
| SERVICENOW INC | COM | 81762P102 |  | 187154294 | 482021 | SH |  | DFND | 1 | 482021 | 0 | 0 |
| SHIFT4 PMTS INC | NOTE 12/1 | 82452JAB5 |  | 8213906 | 8250000 | SH |  | DFND | 1 | 8250000 | 0 | 0 |
| SHOPIFY INC | CL A | 82509L107 |  | 78640677 | 2265649 | SH |  | DFND | 1 | 2265649 | 0 | 0 |
| SIGNATURE BK NEW YORK N Y | COM | 82669G104 |  | 9422461 | 81778 | SH |  | DFND | 1 | 81778 | 0 | 0 |
| SILICON LABORATORIES INC | NOTE 0.625% 6/1 | 826919AD4 |  | 3940070 | 3141000 | SH |  | DFND | 1 | 3141000 | 0 | 0 |
| SITIME CORP | COM | 82982T106 |  | 51844492 | 510180 | SH |  | DFND | 1 | 510180 | 0 | 0 |
| SMARTSHEET INC | COM CL A | 83200N103 |  | 76185334 | 1935603 | SH |  | DFND | 1 | 1935603 | 0 | 0 |
| SNAP INC | NOTE 0.750% 8/0 | 83304AAB2 |  | 1276125 | 1500000 | SH |  | DFND | 1 | 1500000 | 0 | 0 |
| SNOWFLAKE INC | CL A | 833445109 |  | 69413647 | 483584 | SH |  | DFND | 1 | 483584 | 0 | 0 |
| SOLAREDGE TECHNOLOGIES INC | COM | 83417M104 |  | 70525449 | 248969 | SH |  | DFND | 12 | 248969 | 0 | 0 |
| SOLAREDGE TECHNOLOGIES INC | NOTE 9/1 | 83417MAD6 |  | 16204500 | 13000000 | SH |  | DFND | 1 | 13000000 | 0 | 0 |
| SOUTHWEST AIRLS CO | NOTE 1.250% 5/0 | 844741BG2 |  | 8433250 | 7000000 | SH |  | DFND | 1 | 7000000 | 0 | 0 |
| SS TECHNOLOGIES HLDGS INC | COM | 78467J100 |  | 18963167 | 364256 | SH |  | DFND | 1 | 364256 | 0 | 0 |
| SSR MNG INC | NOTE 2.500% 4/0 | 784730AB9 |  | 11268778 | 10039000 | SH |  | DFND | 1 | 10039000 | 0 | 0 |
| STEREOTAXIS INC | COM NEW | 85916J409 |  | 158742 | 76687 | SH |  | DFND | 1 | 76687 | 0 | 0 |
| STRYKER CORPORATION | COM | 863667101 |  | 7203164 | 29462 | SH |  | DFND | 1 | 29462 | 0 | 0 |
| SUNPOWER CORP | COM | 867652406 |  | 2199660 | 122000 | SH |  | DFND | 12 | 122000 | 0 | 0 |
| SUNRUN INC | COM | 86771W105 |  | 5572640 | 232000 | SH |  | DFND | 12 | 232000 | 0 | 0 |
| SUPERNUS PHARMACEUTICALS INC | COM | 868459108 |  | 36352010 | 1019120 | SH |  | DFND | 1 | 1019120 | 0 | 0 |
| SURGERY PARTNERS INC | COM | 86881A100 |  | 405419 | 14552 | SH |  | DFND | 1 | 14552 | 0 | 0 |
| TAKE-TWO INTERACTIVE SOFTWAR | COM | 874054109 |  | 1200098 | 11525 | SH |  | DFND | 1 | 11525 | 0 | 0 |
| TANDEM DIABETES CARE INC | COM NEW | 875372203 |  | 921745 | 20506 | SH |  | DFND | 1 | 20506 | 0 | 0 |
| TE CONNECTIVITY LTD | SHS | H84989104 |  | 8215892 | 71567 | SH |  | DFND | 12 | 71567 | 0 | 0 |
| TECK RESOURCES LTD | CL B | 878742204 |  | 12906415 | 341259 | SH |  | DFND | 1 | 341259 | 0 | 0 |
| TENET HEALTHCARE CORP | COM NEW | 88033G407 |  | 10831038 | 221993 | SH |  | DFND | 1 | 221993 | 0 | 0 |
| TERADYNE INC | COM | 880770102 |  | 46600614 | 533493 | SH |  | DFND | 1 | 533493 | 0 | 0 |
| TESLA INC | COM | 88160R101 |  | 27326744 | 221844 | SH |  | DFND | 1 | 221844 | 0 | 0 |
| THERMO FISHER SCIENTIFIC INC | COM | 883556102 |  | 7454140 | 13536 | SH |  | DFND | 1 | 13536 | 0 | 0 |
| T-MOBILE US INC | COM | 872590104 |  | 25122720 | 179448 | SH |  | DFND | 1 | 179448 | 0 | 0 |
| TORONTO DOMINION BK ONT | COM NEW | 891160509 |  | 15117833 | 233444 | SH |  | DFND | 1 | 233444 | 0 | 0 |
| TRAVELERS COMPANIES INC | COM | 89417E109 |  | 133026592 | 709513 | SH |  | DFND | 1 | 709513 | 0 | 0 |
| TRIMBLE INC | COM | 896239100 |  | 404480 | 8000 | SH |  | DFND | 2 | 8000 | 0 | 0 |
| TRIP COM GROUP LTD | ADS | 89677Q107 |  | 60711459 | 1764868 | SH |  | DFND | 1 | 1764868 | 0 | 0 |
| TRIPADVISOR INC | COM | 896945201 |  | 39281787 | 2184749 | SH |  | DFND | 1 | 2184749 | 0 | 0 |
| TRUPANION INC | COM | 898202106 |  | 48718250 | 1025000 | SH |  | DFND | 1 | 1025000 | 0 | 0 |
| UBER TECHNOLOGIES INC | COM | 90353T100 |  | 11790398 | 476765 | SH |  | DFND | 12 | 476765 | 0 | 0 |
| UBS GROUP AG | SHS | H42097107 |  | 11294773 | 626773 | SH |  | DFND | 1 | 626773 | 0 | 0 |
| UNION PAC CORP | COM | 907818108 |  | 13905786 | 67155 | SH |  | DFND | 1 | 67155 | 0 | 0 |
| UNITED RENTALS INC | COM | 911363109 |  | 33204403 | 93423 | SH |  | DFND | 1 | 93423 | 0 | 0 |
| UNITED THERAPEUTICS CORP DEL | COM | 91307C102 |  | 90349494 | 324893 | SH |  | DFND | 1 | 324893 | 0 | 0 |
| UNITEDHEALTH GROUP INC | COM | 91324P102 |  | 60146270 | 113445 | SH |  | DFND | 1 | 113445 | 0 | 0 |
| US BANCORP DEL | COM NEW | 902973304 |  | 10004701 | 229413 | SH |  | DFND | 1 | 229413 | 0 | 0 |
| US FOODS HLDG CORP | COM | 912008109 |  | 26847665 | 789173 | SH |  | DFND | 1 | 789173 | 0 | 0 |
| VAIL RESORTS INC | NOTE 1/0 | 91879QAN9 |  | 35901250 | 38500000 | SH |  | DFND | 1 | 38500000 | 0 | 0 |
| VEEVA SYS INC | CL A COM | 922475108 |  | 16468990 | 102051 | SH |  | DFND | 1 | 102051 | 0 | 0 |
| VERADIGM INC | COM | 01988P108 |  | 491362 | 27855 | SH |  | DFND | 1 | 27855 | 0 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 |  | 83746200 | 290000 | SH |  | DFND | 1 | 290000 | 0 | 0 |
| VERTIV HOLDINGS CO | COM CL A | 92537N108 |  | 7629110 | 558500 | SH |  | DFND | 12 | 558500 | 0 | 0 |
| VISA INC | COM CL A | 92826C839 |  | 178884061 | 861013 | SH |  | DFND | 1 | 861013 | 0 | 0 |
| VISTEON CORP | COM NEW | 92839U206 |  | 588735 | 4500 | SH |  | DFND | 2 | 4500 | 0 | 0 |
| WALMART INC | COM | 931142103 |  | 8267208 | 58306 | SH |  | DFND | 1 | 58306 | 0 | 0 |
| WELLS FARGO CO NEW | COM | 949746101 |  | 21015536 | 508974 | SH |  | DFND | 1 | 508974 | 0 | 0 |
| WORKDAY INC | CL A | 98138H101 |  | 76793594 | 458935 | SH |  | DFND | 1 | 458935 | 0 | 0 |
| XENON PHARMACEUTICALS INC | COM | 98420N105 |  | 120098812 | 3045874 | SH |  | DFND | 1 | 3045874 | 0 | 0 |
| Y-MABS THERAPEUTICS INC | COM | 984241109 |  | 9720614 | 1991929 | SH |  | DFND | 1 | 1991929 | 0 | 0 |
| ZAI LAB LTD | ADR | 98887Q104 |  | 5365623 | 174776 | SH |  | DFND | 1 | 174776 | 0 | 0 |

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