# EDGAR Filing Document

**Accession Number:** 0001599298
**File Stem:** 0001387131-23-003373
**Filing Date:** 2023-3
**Character Count:** 22423
**Document Hash:** cad018cd9eb89d8b0862a6ac347fa95f
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001387131-23-003373.hdr.sgml**: 20230313

**ACCESSION NUMBER**: 0001387131-23-003373

**CONFORMED SUBMISSION TYPE**: SC 13D/A

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20230313

**DATE AS OF CHANGE**: 20230313

**GROUP MEMBERS**: MAHKAM ZANGANEH REVOCABLE TRUST

**GROUP MEMBERS**: SHAUN ZANGANEH IRREVOCABLE TRUST

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Summit Therapeutics Inc.
- **CENTRAL INDEX KEY:** 0001599298
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13D/A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-88759
- **FILM NUMBER:** 23727962

**BUSINESS ADDRESS:**
- **STREET 1:** 2882 SAND HILL ROAD
- **STREET 2:** SUITE 106
- **CITY:** MENLO PARK
- **STATE:** CA
- **ZIP:** 94025
- **BUSINESS PHONE:** 617-514-7149

**MAIL ADDRESS:**
- **STREET 1:** 2882 SAND HILL ROAD
- **STREET 2:** SUITE 106
- **CITY:** MENLO PARK
- **STATE:** CA
- **ZIP:** 94025

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Summit Therapeutics plc
- **DATE OF NAME CHANGE:** 20150219

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Summit Corp plc
- **DATE OF NAME CHANGE:** 20140205
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Zanganeh Mahkam
- **CENTRAL INDEX KEY:** 0001507650

**FILING VALUES:**
- **FORM TYPE:** SC 13D/A

**MAIL ADDRESS:**
- **STREET 1:** 51 ADAM WAY
- **CITY:** ATHERTON
- **STATE:** CA
- **ZIP:** 94027

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Zanganeh Maky
- **DATE OF NAME CHANGE:** 20101210

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**SCHEDULE 13D**

(Rule 13d-101)

INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT

TO § 240.13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO

§ 240.13d-2(a)

(Amendment No. 3)<sup>1</sup>

<u>Summit Therapeutics Inc.</u>

(Name of Issuer)

<u>Common Stock, par value $0.01 per share</u>

(Title of Class of Securities)

<u>86627T108</u>

(CUSIP Number)

ADAM W. FINERMAN, ESQ.

BAKER HOSTETLER LLP

45 Rockefeller Plaza

New York, New York 10111

<u>(212) 589-4233</u> 

(Name, Address and Telephone Number of Person

Authorized to Receive Notices and Communications)

<u>March 8, 2023</u>

(Date of Event Which Requires Filing of This Statement)

If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box ☐.

*Note:* Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. *See* § 240.13d-7 for other parties to whom copies are to be sent.

_______________

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<sup>1</sup>The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, *see* the *Notes*).

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;1 | &nbsp;&nbsp; NAME OF REPORTING PERSON<br>MAHKAM ZANGANEH | &nbsp;&nbsp; NAME OF REPORTING PERSON<br>MAHKAM ZANGANEH |
| &nbsp;&nbsp;2 | &nbsp;&nbsp; CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) ☒<br> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ☐ | &nbsp;&nbsp; CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) ☒<br> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ☐ |
| &nbsp;&nbsp;3 | &nbsp;&nbsp; SEC USE ONLY | &nbsp;&nbsp; SEC USE ONLY |
| &nbsp;&nbsp;4 | &nbsp;&nbsp; SOURCE OF FUNDS<br>AF | &nbsp;&nbsp; SOURCE OF FUNDS<br>AF |
| &nbsp;&nbsp;5 | &nbsp;&nbsp;CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e) ☐ | &nbsp;&nbsp;CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e) ☐ |
| &nbsp;&nbsp;6 | &nbsp;&nbsp; CITIZENSHIP OR PLACE OF ORGANIZATION<br>U.S.A. | &nbsp;&nbsp; CITIZENSHIP OR PLACE OF ORGANIZATION<br>U.S.A. |
| &nbsp;&nbsp;NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH | &nbsp;&nbsp;7 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SOLE VOTING POWER<br>1,793,138  |
| &nbsp;&nbsp;NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH | &nbsp;&nbsp;8 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SHARED VOTING POWER<br>35,089,255 |
| &nbsp;&nbsp;NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH | &nbsp;&nbsp;9 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SOLE DISPOSITIVE POWER<br>1,793,138  |
| &nbsp;&nbsp;NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH | &nbsp;&nbsp;10 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SHARED DISPOSITIVE POWER<br>35,089,255 |
| &nbsp;&nbsp;11 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>36,882,393\* | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>36,882,393\* |
| &nbsp;&nbsp;12 | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES ☐ | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES ☐ |
| &nbsp;&nbsp;13 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>5.27%\* | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>5.27%\* |
| &nbsp;&nbsp;14 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; TYPE OF REPORTING PERSON<br>IN | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; TYPE OF REPORTING PERSON<br>IN |

---

\* The 36,882,393 shares of Common Stock beneficially owned consist of (i) 34,457,893 shares of Common Stock owned in the aggregate by the Mahkam Zanganeh Revocable Trust and the Shaun Zanganeh Irrevocable Trust, (ii) warrants to purchase 1,121,177 shares of Common Stock (exercisable until December 24, 2029), and (iii) options to purchase 1,303,323 shares of Common Stock (exercisable beginning on December 31, 2020 and exercisable until November 11, 2030). Of the warrants to purchase 1,121,177 shares of Common Stock, 489,815 are held individually by Dr. Zanganeh, and 315,681 are held by each of the Mahkam Zanganeh Revocable Trust and the Shaun Zanganeh Irrevocable Trust. The options to purchase 1,303,323 shares of Common Stock are held individually by Dr. Zanganeh

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;1 | &nbsp;&nbsp; NAME OF REPORTING PERSON<br>MAHKAM ZANGANEH REVOCABLE TRUST | &nbsp;&nbsp; NAME OF REPORTING PERSON<br>MAHKAM ZANGANEH REVOCABLE TRUST |
| &nbsp;&nbsp;2 | &nbsp;&nbsp; CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) ☒<br> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (b) ☐ | &nbsp;&nbsp; CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) ☒<br> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (b) ☐ |
| &nbsp;&nbsp;3 | &nbsp;&nbsp; SEC USE ONLY | &nbsp;&nbsp; SEC USE ONLY |
| &nbsp;&nbsp;4 | &nbsp;&nbsp; SOURCE OF FUNDS<br>WC | &nbsp;&nbsp; SOURCE OF FUNDS<br>WC |
| &nbsp;&nbsp;5 | &nbsp;&nbsp;CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e) ☐ | &nbsp;&nbsp;CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e) ☐ |
| &nbsp;&nbsp;6 | &nbsp;&nbsp; CITIZENSHIP OR PLACE OF ORGANIZATION<br>CALIFORNIA | &nbsp;&nbsp; CITIZENSHIP OR PLACE OF ORGANIZATION<br>CALIFORNIA |
| &nbsp;&nbsp;NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH | &nbsp;&nbsp;7 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SOLE VOTING POWER<br>- 0 - |
| &nbsp;&nbsp;NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH | &nbsp;&nbsp;8 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SHARED VOTING POWER<br>24,889,479 \* |
| &nbsp;&nbsp;NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH | &nbsp;&nbsp;9 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SOLE DISPOSITIVE POWER<br>- 0 - |
| &nbsp;&nbsp;NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH | &nbsp;&nbsp;10 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SHARED DISPOSITIVE POWER<br>24,889,479 \* |
| &nbsp;&nbsp;11 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>24,889,479 \* | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>24,889,479 \* |
| &nbsp;&nbsp;12 | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES ☐ | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES ☐ |
| &nbsp;&nbsp;13 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>3.57%\* | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>3.57%\* |
| &nbsp;&nbsp;14 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; TYPE OF REPORTING PERSON<br>OO | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; TYPE OF REPORTING PERSON<br>OO |

---

\* The 24,889,479 shares of Common Stock beneficially owned consist of 24,573,798 shares of Common Stock and warrants to purchase 315,681 shares of Common Stock.

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;1 | &nbsp;&nbsp; NAME OF REPORTING PERSON<br>SHAUN ZANGANEH IRREVOCABLE TRUST | &nbsp;&nbsp; NAME OF REPORTING PERSON<br>SHAUN ZANGANEH IRREVOCABLE TRUST |
| &nbsp;&nbsp;2 | &nbsp;&nbsp; CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) ☒<br> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ☐ | &nbsp;&nbsp; CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) ☒<br> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ☐ |
| &nbsp;&nbsp;3 | &nbsp;&nbsp; SEC USE ONLY | &nbsp;&nbsp; SEC USE ONLY |
| &nbsp;&nbsp;4 | &nbsp;&nbsp; SOURCE OF FUNDS<br>WC | &nbsp;&nbsp; SOURCE OF FUNDS<br>WC |
| &nbsp;&nbsp;5 | &nbsp;&nbsp;CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e) ☐ | &nbsp;&nbsp;CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e) ☐ |
| &nbsp;&nbsp;6 | &nbsp;&nbsp; CITIZENSHIP OR PLACE OF ORGANIZATION<br>CALIFORNIA | &nbsp;&nbsp; CITIZENSHIP OR PLACE OF ORGANIZATION<br>CALIFORNIA |
| &nbsp;&nbsp;NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH | &nbsp;&nbsp;7 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SOLE VOTING POWER<br>- 0 - |
| &nbsp;&nbsp;NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH | &nbsp;&nbsp;8 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SHARED VOTING POWER<br>10,199,776 \* |
| &nbsp;&nbsp;NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH | &nbsp;&nbsp;9 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SOLE DISPOSITIVE POWER<br>- 0 - |
| &nbsp;&nbsp;NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH | &nbsp;&nbsp;10 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SHARED DISPOSITIVE POWER<br>10,199,776 \* |
| &nbsp;&nbsp;11 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>10,199,776\* | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br>10,199,776\* |
| &nbsp;&nbsp;12 | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES ☐ | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES ☐ |
| &nbsp;&nbsp;13 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>1.46%\* | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)<br>1.46%\* |
| &nbsp;&nbsp;14 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; TYPE OF REPORTING PERSON<br>OO | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; TYPE OF REPORTING PERSON<br>OO |

---

\* The 10,199,776 shares of Common Stock beneficially owned consist of 9,884,095 shares of Common Stock and warrants to purchase 315,681 shares of Common Stock.

The following constitutes the Schedule 13D/A filed by the undersigned (as amended hereby, the "<u>Schedule 13D</u>").

---

| | |
|:---|:---|
| Item | 3. <u>Source and Amount of Funds or Other Consideration</u>. |

---

Item 3 is hereby amended to add the following:

The Reporting Persons paid approximately $24,703,396.20 in exchange for 23,527,044 shares of Common Stock issued by the Issuer in the rights offering. The Reporting Persons paid such consideration using trust funds.

Item 4. <u>Purpose of Transaction</u>.

Item 4 is hereby amended to add the following:

The Issuer commenced a rights offering on February 7, 2023 to raise proceeds of approximately $500 million. The Reporting Persons subscribed for their full basic subscription rights and oversubscription rights available in the rights offering, purchasing shares of Common Stock of the Issuer at a price of $1.05 per share on the same terms as those available to all holders of the Issuer's Common Stock who received subscription rights in the rights offering.

Item 5. <u>Interest in Securities of the Issuer</u>.

Items 5(a)-(c) are hereby amended and restated to read as follows:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) The aggregate percentage of Common Stock reported owned by the Reporting
Persons is based on the Issuer's calculation that it has 697,685,365 shares of Common Stock outstanding on March 7, 2023, as reported
in the Issuer's Annual Report on Form 10-K, filed with the Securities and Exchange Commission on March 9, 2023. As of the close of business
on March 8, 2023 through the holding of 34,457,893 shares of Common Stock plus shares underlying the warrants to purchase 1,121,177 shares
of Common Stock, (i) Trust I beneficially owned approximately 3.57% of the shares of Common Stock outstanding through the holding of 24,573,798
shares of Common Stock plus shares underlying the warrants to purchase 315,681 shares of Common Stock, (ii) Trust II beneficially owned
approximately 1.46% of the shares of Common Stock outstanding through the holding of 9,884,095 shares of Common Stock plus shares underlying
the warrants to purchase 315,681 shares of Common Stock, and (iii) Dr. Zanganeh personally beneficially owned(excluding Trust I and Trust
II ownership) approximately 0.26% of the Common Stock outstanding through the holding of shares underlying the warrants to purchase 489,815
shares of Common Stock plus shares underlying options to purchase 1,303,323 shares of Common Stock. Dr. Zanganeh, as sole trustee of each
Trust, may be deemed to beneficially own in the aggregate 34,457,893 shares of Common Stock, warrants to purchase 1,121,177 shares of
Common Stock, and options to purchase 1,303,323 shares of Common Stock. Based on the foregoing, Dr. Zanganeh's beneficial ownership would
constitute approximately 5.27% of the Common Stock outstanding.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Dr. Zanganeh has sole power to vote and direct the disposition of 1,793,138
shares of Common Stock (consisting of the warrant to purchase 489,815 shares of Common Stock and options to purchase 1,303,323 shares
of Common Stock, each on an as-exercised basis). By virtue of Dr. Zanganeh's position as the sole trustee of each Trust, she may
be deemed to have the shared power to vote and direct the disposition of 36,882,393 shares of Common Stock in the aggregate (including
the warrants and options disclosed herein on an as-exercised basis). Trust I may be deemed to have the shared power to vote and direct
the disposition of 24,889,479 shares of Common Stock in the aggregate (including the warrants disclosed herein on an as-exercised basis).
Trust II may be deemed to have the shared power to vote and direct the disposition of 10,199,776 shares of Common Stock in the aggregate
(including the warrants disclosed herein on an as-exercised basis).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) The transactions in the Common Stock by the Reporting Persons during the past sixty days are set forth
in Schedule A and are incorporated herein by reference.

<u>SIGNATURES</u>

After reasonable inquiry and to the best of his knowledge and belief, each of the undersigned certifies that the information set forth in this statement is true, complete and correct.

Dated: March 13, 2023

---

| | |
|:---|:---|
| /s/ Mahkam Zanganeh | /s/ Mahkam Zanganeh |
| Mahkam Zanganeh | Mahkam Zanganeh |
| <br> MAHKAM ZANGANEH REVOCABLE TRUST | <br> MAHKAM ZANGANEH REVOCABLE TRUST |
| SHAUN ZANGANEH IRREVOCABLE TRUST | SHAUN ZANGANEH IRREVOCABLE TRUST |
| By: | /s/ Mahkam Zanganeh |
| Name:<br> Title: | Mahkam Zanganeh<br> Trustee |

---

**<u>SCHEDULE A</u>**

<u>Transactions in the Common Stock During the Past Sixty Days</u>

---

| | | | |
|:---|:---|:---|:---|
| &nbsp;&nbsp; <br> <u>Type of Security</u> | &nbsp;&nbsp;Securities<br> <u>Purchased / (Sold)</u> | &nbsp;&nbsp;Price Per<br> <u>Share($)</u> | &nbsp;&nbsp;Date of<br> <u>Purchase / Sale</u> |

---

**<u>MAHKAM ZANGANEH REVOCABLE TRUST</u>**

---

| | | | |
|:---|:---|:---|:---|
| &nbsp;&nbsp;Common Stock | &nbsp;&nbsp;16778415 | &nbsp;&nbsp;$1.05 | &nbsp;&nbsp;March 8, 2023 |
| &nbsp;&nbsp;**<u>SHAUN ZANGANEH IRREVOCABLE TRUST</u>** | &nbsp;&nbsp;**<u>SHAUN ZANGANEH IRREVOCABLE TRUST</u>** | &nbsp;&nbsp;**<u>SHAUN ZANGANEH IRREVOCABLE TRUST</u>** | &nbsp;&nbsp;**<u>SHAUN ZANGANEH IRREVOCABLE TRUST</u>** |
| &nbsp;&nbsp;Common Stock | &nbsp;&nbsp;6748629 | &nbsp;&nbsp;$1.05 | &nbsp;&nbsp;March 8, 2023 |

---