# EDGAR Filing Document

**Accession Number:** 0001434868
**File Stem:** 0001628280-25-039392
**Filing Date:** 2025-8
**Character Count:** 33932
**Document Hash:** 2f566da1d8adaef9ddd1385da598a3ed
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001628280-25-039392.hdr.sgml**: 20250811

**ACCESSION NUMBER**: 0001628280-25-039392

**CONFORMED SUBMISSION TYPE**: 8-K/A

**PUBLIC DOCUMENT COUNT**: 13

**CONFORMED PERIOD OF REPORT**: 20250805

**ITEM INFORMATION**: Results of Operations and Financial Condition

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20250811

**DATE AS OF CHANGE**: 20250811

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Esperion Therapeutics, Inc.
- **CENTRAL INDEX KEY:** 0001434868
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K/A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-35986
- **FILM NUMBER:** 251200258

**BUSINESS ADDRESS:**
- **STREET 1:** 3891 RANCHERO DRIVE, SUITE 150
- **CITY:** ANN ARBOR
- **STATE:** MI
- **ZIP:** 48108
- **BUSINESS PHONE:** 734-887-3903

**MAIL ADDRESS:**
- **STREET 1:** 3891 RANCHERO DRIVE, SUITE 150
- **CITY:** ANN ARBOR
- **STATE:** MI
- **ZIP:** 48108

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** HDL THERAPEUTICS INC
- **DATE OF NAME CHANGE:** 20080513

?xml version='1.0' encoding='ASCII'? espr-20250805

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**WASHINGTON, D.C. 20549**

**FORM 8-K/A**

**(Amendment No. 1)**

**CURRENT REPORT**

**Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934**

Date of Report (Date of Earliest Event Reported): **August 5, 2025**

**Esperion Therapeutics, Inc.**

(Exact name of registrant as specified in its charter)

---

| | | |
|:---|:---|:---|
| **Delaware** | **001-35986** | **26-1870780** |
| (State or other jurisdiction of<br>incorporation) | (Commission File Number) | (I.R.S. Employer<br>Identification No.) |

---

**3891 Ranchero Drive, Suite 150**

**Ann Arbor, MI**

(Address of principal executive offices)

**48108**

(Zip Code)

Registrant's telephone number, including area code: **(734) 887-3903**

**Not Applicable**

Former name or former address, if changed since last report

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

---

| | | |
|:---|:---|:---|
| **Title of each class** | **Trading Symbol** | **Name of each exchange on which registered** |
| Common Stock, par value $0.001 per share | ESPR | NASDAQ Stock Market LLC |

---

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 or Rule 12b-2 of the Securities Exchange Act of 1934.

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.&nbsp;&nbsp;&nbsp;&nbsp; ☐

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**Explanatory Note**

Esperion Therapeutics, Inc. (the "Company") is filing this Current Report on Form 8-K/A (this "Amendment No. 1") to amend the Company's Current Report on Form 8-K filed with the Securities and Exchange Commission on August 5, 2025 (the "Original Form 8-K") under Items 2.02 and 9.01, which announced its financial results for the three and six months ended June 30, 2025, as presented in a press release dated August 5, 2025, furnished as Exhibit 99.1 thereto (the "Earnings Release"). This Amendment No. 1 is being filed to correct certain disclosures in the Earnings Release contained in the tables entitled "Balance Sheet Data" for the period ended June 30, 2025 and "Statement of Operations" for the three and six months ended June 30, 2025, as well as the corresponding figures included in the narrative sections in the Earnings Release for the net income (loss) and net income (loss) per share for the three and six months ended June 30, 2025, and income from operations for the three months ended June 30, 2025, and to correct corresponding references made during the Company's second quarter 2025 earnings call held on August 5, 2025. Other than the corrections discussed in this Amendment No. 1, as described in Item 2.02 herein, all other information disclosed in the Original Form 8-K, Earnings Release, and earnings call remains unchanged. A corrected version of the Earnings Release is furnished herewith as Exhibit 99.1.

**Item 2.02. Results of Operations and Financial Condition.**

On August 11, 2025, the Company furnished a press release announcing certain of its preliminary financial results for the three and six months ended June 30, 2025. A copy of the press release is furnished herewith as Exhibit 99.1.

The Company has not yet completed its quarter-end financial close process for the quarter ended June 30, 2025. The preliminary financial data included in Exhibit 99.1 attached hereto has been prepared by, and is the responsibility of, the Company's management, is based on preliminary unaudited information and management estimates for the quarter ended June 30, 2025, is not a comprehensive statement of the Company's financial results, and is subject to completion of the Company's financial closing procedures. There can be no assurance that the Company's actual financial results as of June 30, 2025 will not differ from these estimates, including as a result of the completion of the Company's final adjustments, and other developments that may arise between the date of this filing and the time the Company's financial results for such period are finalized, and any such changes could be material. These estimates should not be viewed as a substitute for interim financial statements prepared in accordance with accounting principles generally accepted in the United States and they are not necessarily indicative of the results to be achieved in any future period. Complete results as of June 30, 2025 will be included in the Company's Quarterly Report on Form 10-Q for the quarter ended June 30, 2025. The Company assumes no duty to update these preliminary estimates, except as required by law.

The information set forth under Item 2.02 and in Exhibit 99.1 attached hereto is intended to be furnished and shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended (the "Securities Act"), or the Exchange Act, except as expressly set forth by specific reference in such filing.

**Cautionary Note Regarding Forward-Looking Statements**

This Current Report on Form 8-K contains forward-looking statements within the meaning of Section 27A of the Securities Act and Section 21E of the Exchange Act. Any statements about the Company's expectations, beliefs, plans, objectives, assumptions or future events or performance are not historical facts and may be forward-looking. These statements are often, but are not always, made through the use of words or phrases such as "may," "will," "could," "should," "expects," "intends," "plans," "anticipates," "believes," "estimates," "predicts," "projects," "potential," "continue," and similar expressions, or the negative of these terms. These forward-looking statements include statements about the Company's preliminary financial results. Accordingly, these statements involve estimates, assumptions and uncertainties which could cause actual results to differ materially from those expressed in them. Any forward-looking statements are qualified in their entirety by reference to the factors detailed in the Company's Annual Report on Form 10-K for the year ended December 31, 2024, Quarterly Report on Form 10-Q for the quarter ended March 31, 2025, and in any of the Company's subsequent filings with the Securities and Exchange Commission. Any forward-looking statements contained in this press release speak only as of the date hereof, and the Company disclaims any obligation or undertaking to update or revise any forward-looking statements contained in this press release, other than to the extent required by law.

------

**Item 9.01. Financial Statements and Exhibits.**

(d) Exhibits

---

| | |
|:---|:---|
| **Exhibit No.** | **Description** |
| <u>[99.1](a991q22025earningsreleasea.htm)</u> | <u>[Press Release dated August](a991q22025earningsreleasea.htm)[11](a991q22025earningsreleasea.htm)[, 2025](a991q22025earningsreleasea.htm)</u> |
| 104 | The cover page from this Current Report on Form 8-K, formatted in Inline XBRL. |

---

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**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

---

| | | |
|:---|:---|:---|
| Date: August 11, 2025 | Esperion Therapeutics, Inc. | Esperion Therapeutics, Inc. |
|  | By: | /s/ Sheldon L. Koenig |
|  |  | Sheldon L. Koenig |
|  |  | President and Chief Executive Officer |

---

## Exhibit 99.1

**Exhibit 99.1**

**Correcting and Replacing: Esperion Reports Second Quarter 2025 Financial Results and Provides Business Update**

Esperion Therapeutics, Inc. (the "Company") is replacing in its entirety its earnings press release for the second quarter ended June 30, 2025, originally issued on August 5, 2025 (the "Earnings Release"), to correct certain disclosures contained in the tables entitled "Balance Sheet Data" for the period ended June 30, 2025 and "Statement of Operations" for the three and six months ended June 30, 2025, as well as the corresponding figures included in the narrative sections in the Earnings Release for the net income (loss) and net income (loss) per share for the three and six months ended June 30, 2025, and income from operations for the three months ended June 30, 2025, and to correct corresponding references made during the Company's second quarter 2025 earnings call held on August 5, 2025. All references in the Earnings Release to "conference call," "call," "webcast," "today," and similar terms, and to the corresponding date and time, refer to the earnings call held on August 5, 2025, at 8:00 a.m. ET. Other than the corrections discussed herein, all other information disclosed in the Earnings Release and earnings call remains unchanged.

The corrected Earnings Release reads:

**Esperion Reports Preliminary Second Quarter 2025 Financial Results and Provides Business Update**

*– Q2 2025 Total Revenue Grew 12% Y/Y to $82.4 Million –*

*– Q2 2025 U.S. Net Product Revenue Grew 42% Y/Y to $40.3 Million –*

*– Total Retail Prescription Equivalents Increased 10% from First Quarter –*

*– Reached Settlement Agreements with Three ANDA Filers Not to Market Generic Versions of NEXLETOL*<sup>®</sup> *(bempedoic acid) Prior to 2040 –*

*– First Quarter of Operating Income from Ongoing Business with Plans for Sustainable Profitability Starting in Q1 2026 –*

*– Conference Call and Webcast Today at 8:00 a.m. ET –* 

ANN ARBOR, Mich., Aug. 11, 2025 (GLOBE NEWSWIRE) – Esperion (NASDAQ: ESPR) today reported certain of its preliminary financial results for the second quarter ended June 30, 2025, and provided a business update.

"Our preliminary second quarter results reflect the strength of our commercial execution and the growing adoption of our bempedoic acid therapies in cardiovascular disease prevention. With more than 15% sequential quarterly growth and 42% year-over-year quarterly growth in net U.S. product sales, we are delivering on our commitment to patients and shareholders alike," stated Sheldon Koenig, President and CEO of Esperion. "The three recent ANDA settlements also demonstrate our commitment to protecting our intellectual property portfolio and reflect our belief in the strength of our patents. As we continue to expand access to these life-saving therapies through

------

improved payer dynamics and prepare to launch our consumer television ad on connected TV, such as Hulu and NBC Sports, we remain focused on driving sustained revenue growth. In parallel, we are advancing our clinical pipeline and pursuing strategic portfolio expansion to shape the future of cardiovascular disease prevention worldwide. Importantly, we delivered our first quarter of operating income from ongoing business and expect our continued growth and achievements to support sustainable profitability beginning in the first quarter of 2026. With strong momentum, we are moving forward with confidence."

"As we advance our growing leadership in cardiovascular diseases, we are proud to welcome Robert Hoffman and Craig Thompson, both seasoned executives with a wealth of commercial and operational expertise, to our Board of Directors," added Koenig.

**Second Quarter 2025 Key Accomplishments and Recent Highlights** 

*Advancing the U.S. Commercial Strategy* 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Reached settlement agreements with three ANDA filers not to market generic version of NEXLETOL<sup>®</sup> (bempedoic acid) until 2040.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Continued to reinforce our differentiated cardiovascular (CV) risk reduction data in Primary Prevention and statin intolerance through both our sales force and healthcare provider (HCP) digital channels.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;◦ Nearly one quarter of prescriptions were written by physicians reached through digital touchpoints only.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;◦ Established strong branding within statin intolerant population with new marketing campaign focused on, "Can't take a statin? Make NEXLIZET happen!".

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Strengthened access and reimbursement support for NEXLETOL and NEXLIZET<sup>®</sup> (bempedoic acid and ezetimibe), driving greater confidence among payers and HCPs.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Additions to the Company's field reimbursement team have made great strides in supporting our growing prescriber base by educating over 1,100 target prescribers on NEXLETOL and NEXLIZET's favorable reimbursement landscape. This was evident by an increase in all targeted business approval rates to over 80%.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Increased total retail prescription equivalents by approximately 10% and grew the number of healthcare practitioners writing prescriptions for NEXLETOL and NEXLIZET to more than 28,000 in the second quarter of 2025.

*Global Expansion* 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• The Company's partner in Japan, Otsuka Pharmaceutical Co., Ltd. is on track for expected approval and National Health Insurance pricing in the second half of 2025.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Esperion's European partner Daiichi Sankyo Europe (DSE) continues to show strong revenue growth and market penetration for NILEMDO<sup>®</sup> (bempedoic acid) and NUSTENDI<sup>®</sup> (bempedoic acid and ezetimibe), having surpassed the 500,000-patient mark during the second quarter.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;◦ Royalty revenue increased 30% sequentially to $13.6 million, continuing to underscore the ongoing opportunity in Europe for sales of NILEMDO and NUSTENDI.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;◦ Advanced multiple processes for the technology transfer for manufacturing of NILEMDO and NUSTENDI to DSE, with certain working capital benefits expected in 2025.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Partnered with HLS Therapeutics for the exclusive rights to commercialize NEXLETOL and NEXLIZET in Canada. The Company's previously filed New Drug Submissions to Health Canada are on track for review with an expected market approval in the fourth quarter of 2025.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• The Company and its partner in Israel, Neopharm Israel, remain on track for market approval of NEXLETOL and NEXLIZET in the first half of 2026.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• CSL Seqirus, the Company's partner in Australia and New Zealand, filed a marketing application in Australia for NEXLETOL and NEXLIZET in July 2025, and expects market approval in Q4 2026.

***Preliminary Second Quarter and YTD 2025 Financial Results*** 

*Revenue* 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Total revenue for the three and six months ended June 30, 2025 was $82.4 million and $147.4 million, respectively, compared to $73.8 million and $211.6 million for the comparable periods in 2024, an increase of 12% and a decrease of 30%, respectively. Excluding the one-time settlement agreement milestones received in the three months ended June 30, 2024, total revenue grew 69%.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• U.S. net product revenue for the three and six months ended June 30, 2025 was $40.3 million and $75.2 million, respectively, compared to $28.3 million and $53.1 million, for the comparable periods in 2024, an increase of 42% for each respective period.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Collaboration revenue was $42.1 million and $72.2 million for the three and six months ended June 30, 2025, respectively, compared to $45.5 million and $158.5 million for the comparable periods in 2024, a decrease of approximately 7% and 54%, respectively.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;◦ The decreases were driven by the settlement agreement milestone with DSE received in the three and six months ended June 30, 2024, offset partially by increases in royalty sales within our partner territories and product sales to our collaboration partners from our supply agreements. Excluding the settlement agreement milestones, collaboration revenue grew approximately 105% and 102% from the comparable periods.

*R&D Expenses* 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Research and development expenses for the three and six months ended June 30, 2025 were $7.2 million and $19.8 million, respectively, compared to $11.5 million and $24.9 million for the comparable periods in 2024, a decrease of 37% and 20%, respectively.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;◦ The decrease in research and development expenses was primarily attributable to decreased costs for ongoing clinical studies and decreased compensation costs, including bonus, stock compensation and consulting.

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*Selling, General and Administrative (SG&A) Expenses* 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Selling, general and administrative expenses for the three and six months ended June 30, 2025 were $39.5 million and $82.5 million, respectively, compared to $44.2 million and $86.2 million for the comparable periods in 2024, a decrease of 11% and 4%, respectively.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;◦ The decrease was primarily related to decreased media and marketing costs.

*Net Income (Loss).* For the three and six months ended June 30, 2025, the Company had net losses of $12.7 million and $53.2 million, respectively, compared to net losses of $61.9 million and $0.9 million for the comparable periods in 2024. For the three months ended June 30, 2025, the Company achieved income from operations of approximately $7.1 million, marking the first quarter of operating income from ongoing operations in the Company's history and a significant year-over-year improvement.

*Net Income (Loss) Per Share.* Basic and diluted net losses per share for the three and six months ended June 30, 2025 were $0.06 and $0.27, respectively, compared to basic and diluted losses per share of $0.33 and $0.01, for the comparable periods in 2024, respectively.

*Cash and Cash Equivalents.* As of June 30, 2025, cash and cash equivalents totaled $86.1 million compared to $144.8 million as of December 31, 2024.

The Company ended the quarter with approximately 200.2 million shares of common stock outstanding, excluding 2.0 million treasury shares.

*2025 Financial Outlook* 

The Company reiterates its expectation for full year 2025 operating expenses to be in the range of $215 million to $235 million, including approximately $15 million in non-cash expenses related to stock compensation. Based on the strength of the Company's performance, Esperion now expects to achieve sustainable profitability beginning in the first quarter of 2026.

**Conference Call and Webcast Information** 

Esperion will host a conference call and webcast at 8:00 a.m. ET to discuss the preliminary financial results and business progress.

A live audio webcast can be accessed on the investor and media section of the Esperion website. The webcast replay will be available approximately two hours after completion of the call and will be archived on the Company's website for approximately 90 days.

**INDICATION** 

NEXLIZET and NEXLETOL are indicated:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• The bempedoic acid component of NEXLIZET and NEXLETOL is indicated to reduce the risk of myocardial infarction and coronary revascularization in adults

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who are unable to take recommended statin therapy (including those not taking a statin) with:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;◦ established cardiovascular disease (CVD), or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;◦ at high risk for a CVD event but without established CVD.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• As an adjunct to diet:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;◦ NEXLIZET, alone or in combination with other LDL-C lowering therapies, to reduce LDL-C in adults with primary hyperlipidemia, including HeFH.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;◦ NEXLETOL, in combination with other LDL-C lowering therapies, or alone when concomitant LDL-C lowering therapy is not possible, to reduce LDL-C in adults with primary hyperlipidemia, including HeFH.

**IMPORTANT SAFETY INFORMATION** 

NEXLIZET and NEXLETOL are contraindicated in patients with a prior hypersensitivity to bempedoic acid or ezetimibe or any of the excipients. Serious hypersensitivity reactions including anaphylaxis, angioedema, rash, and urticaria have been reported.

*Hyperuricemia:* Bempedoic acid, a component of NEXLIZET and NEXLETOL, may increase blood uric acid levels, which may lead to gout. Hyperuricemia may occur early in treatment and persist throughout treatment, returning to baseline following discontinuation of treatment. Assess uric acid levels periodically as clinically indicated. Monitor for signs and symptoms of hyperuricemia, and initiate treatment with urate-lowering drugs as appropriate.

*Tendon Rupture:* Bempedoic acid, a component of NEXLIZET and NEXLETOL, is associated with an increased risk of tendon rupture or injury. Tendon rupture may occur more frequently in patients over 60 years of age, in those taking corticosteroid or fluoroquinolone drugs, in patients with renal failure, and in patients with previous tendon disorders. Discontinue NEXLIZET or NEXLETOL at the first sign of tendon rupture. Consider alternative therapy in patients who have a history of tendon disorders or tendon rupture.

The most common adverse reactions in the primary hyperlipidemia trials of bempedoic acid, a component of NEXLIZET and NEXLETOL, in ≥2% of patients and greater than placebo were upper respiratory tract infection, muscle spasms, hyperuricemia, back pain, abdominal pain or discomfort, bronchitis, pain in extremity, anemia, and elevated liver enzymes.

Adverse reactions reported in ≥2% of patients treated with ezetimibe (a component of NEXLIZET) and at an incidence greater than placebo in clinical trials were upper respiratory tract infection, diarrhea, arthralgia, sinusitis, pain in extremity, fatigue, and influenza.

In the primary hyperlipidemia trials of NEXLIZET, the most commonly reported adverse reactions (incidence ≥3% and greater than placebo) observed with NEXLIZET, but not observed in clinical trials of bempedoic acid or ezetimibe, were urinary tract infection, nasopharyngitis, and constipation.

The most common adverse reactions in the cardiovascular outcomes trial for bempedoic acid, a component of NEXLIZET and NEXLETOL, at an incidence of ≥2% and 0.5%

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greater than placebo were hyperuricemia, renal impairment, anemia, elevated liver enzymes, muscle spasms, gout, and cholelithiasis.

Discontinue NEXLIZET or NEXLETOL when pregnancy is recognized unless the benefits of therapy outweigh the potential risks to the fetus. Because of the potential for serious adverse reactions in a breast-fed infant, breastfeeding is not recommended during treatment with NEXLIZET or NEXLETOL.

Report pregnancies to Esperion Therapeutics, Inc. Adverse Event reporting line at 1-833-377-7633.

Please see full Prescribing Information for NEXLIZET and NEXLETOL.

**About Esperion Therapeutics** 

Esperion Therapeutics, Inc. is a commercial stage biopharmaceutical company focused on bringing new medicines to market that address unmet needs of patients and healthcare professionals. The Company developed and is commercializing the only U.S. Food and Drug Administration (FDA) approved oral, once-daily, non-statin medicines for patients who are at risk for cardiovascular disease and are struggling with elevated low density lipoprotein cholesterol (LDL-C). These medications are supported by the nearly 14,000 patient CLEAR Cardiovascular Outcomes Trial. Esperion continues to build on its success with its next generation program which is focused on developing ATP citrate lyase inhibitors (ACLYi). New insights into the structure and function of ACLYi fully enables rational drug design and the opportunity to develop highly potent and specific inhibitors with allosteric mechanisms.

Esperion continues to evolve into a leading global biopharmaceutical company through commercial execution, international partnerships and collaborations and advancement of its pre-clinical pipeline. For more information, visit esperion.com and follow Esperion on LinkedIn and X.

**Certain Unaudited Preliminary Financial Results**

The Company has not yet completed its quarter-end financial close process for the quarter ended June 30, 2025. The preliminary financial data included in this press release has been prepared by, and is the responsibility of, the Company's management, is based on preliminary unaudited information and management estimates for the quarter ended June 30, 2025, is not a comprehensive statement of the Company's financial results, and is subject to completion of the Company's financial closing procedures. There can be no assurance that the Company's actual financial results as of June 30, 2025 will not differ from these estimates, including as a result of the completion of the Company's final adjustments, and other developments that may arise between the date of this press release and the time the Company's financial results for such period are finalized, and any such changes could be material. These estimates should not be viewed as a substitute for interim financial statements prepared in accordance with accounting principles generally accepted in the United States and they are not necessarily indicative of the results to be achieved in any future period. Complete results as of June 30, 2025 will be included in the Company's Quarterly Report on Form 10-Q for the quarter ended June 30, 2025. The Company assumes no duty to update these preliminary estimates, except as required by law.

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**Forward-Looking Statements** 

This press release contains forward-looking statements that are made pursuant to the safe harbor provisions of the federal securities laws, including statements regarding the Company's preliminary financial results, marketing strategy and commercialization plans, current and planned operational expenses, expected profitability, future operations, commercial products, clinical development, including the timing, designs and plans for the CLEAR Outcomes study and its results, plans for potential future product candidates, financial condition and outlook, including expected cash runway and profitability, and other statements containing the words "preliminary," "anticipate," "believe," "estimate," "expect," "intend," "may," "plan," "predict," "project," "suggest," "target," "potential," "will," "would," "could," "should," "continue," and similar expressions. Any express or implied statements contained in this press release that are not statements of historical fact may be deemed to be forward-looking statements. Forward-looking statements involve risks and uncertainties that could cause Esperion's actual results to differ significantly from those projected, including, without limitation, the risk that certain preliminary financial results reported herein reflect information available to the Company only at this time and involve estimates, assumptions and uncertainties which could cause actual results to differ materially from those expressed herein as a result of the Company's final adjustments, and other developments that may arise between the date of this press release and the time the Company's financial results for such period are finalized, net sales, profitability, and growth of Esperion's commercial products, clinical activities and results, supply chain, commercial development and launch plans, the outcomes and anticipated benefits of legal proceedings and settlements, and the risk that the Company's financial closing procedures may not be completed within the anticipated timeframe to timely file the Form 10-Q, as well as other risks and uncertainties detailed in Esperion's most recent Annual Report on Form 10-K for the year ended December 31, 2024, Quarterly Report on Form 10-Q for the quarter ended March 31, 2025, and in any of its subsequent filings with the Securities and Exchange Commission. Any forward-looking statements contained in this press release speak only as of the date hereof, and Esperion disclaims any obligation or undertaking to update or revise any forward-looking statements contained in this press release, other than to the extent required by law.

**Esperion Contact Information:** 

Investors:

Alina Venezia

<u>investorrelations@esperion.com</u> 

(734) 887-3903

Media:

Tiffany Aldrich

<u>corporateteam@esperion.com</u> 

(616) 443-8438

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**Esperion Therapeutics, Inc.**

**Balance Sheet Data**

**(In thousands)**

**(Unaudited)**

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| | | |
|:---|:---|:---|
| | **June 30, <br>2025** | **December 31, 2024** |
| Cash and cash equivalents | $86061 | $144761 |
| Working capital | 43799 | 91765 |
| Total assets | 347085 | 343821 |
| Royalty sale liability | 295912 | 293610 |
| Convertible notes, net of issuance costs | 151764 | 151320 |
| Long-term debt | 146452 | 140971 |
| Common stock | 200 | 196 |
| Accumulated deficit | (1654209) | (1601029) |
| Total stockholders' deficit | (433509) | (388722) |

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**Esperion Therapeutics, Inc.**

**Statement of Operations**

**(In thousands, except share and per share data)**

**(Unaudited)**

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| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended<br>June 30,** | **Three Months Ended<br>June 30,** | **Six Months Ended<br>June 30,** | **Six Months Ended<br>June 30,** |
| | **2025** | **2024** | **2025** | **2024** |
| **Revenues:** |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Product sales, net | $40274 | $28302 | $75187 | $53058 |
| &nbsp;&nbsp;&nbsp;Collaboration revenue | 42111 | 45532 | 72193 | 158511 |
| Total Revenues | 82385 | 73834 | 147380 | 211569 |
| **Operating expenses:** |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Cost of goods sold | 28543 | 15609 | 60081 | 25684 |
| &nbsp;&nbsp;&nbsp;Research and development | 7238 | 11461 | 19795 | 24864 |
| &nbsp;&nbsp;&nbsp;Selling, general and administrative | 39509 | 44185 | 82505 | 86173 |
| Total operating expenses | 75290 | 71255 | 162381 | 136721 |
| **Income (loss) from operations** | 7095 | 2579 | (15001) | 74848 |
| Interest expense | (20486) | (13723) | (39917) | (27747) |
| Loss on extinguishment of debt |  | (53235) |  | (53235) |
| Other income, net | 666 | 2454 | 1738 | 5231 |
| **Net loss** | $(12725) | $(61925) | $(53180) | $(903) |
| Net loss per common share - basic and diluted | $(0.06) | $(0.33) | $(0.27) | $(0.01) |
| Weighted-average shares outstanding - basic and diluted | 197546239 | 188793816 | 196841011 | 179026191 |

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