# EDGAR Filing Document

**Accession Number:** 0001709626
**File Stem:** 0000000000-25-006255
**Filing Date:** 2025-6
**Character Count:** 2845
**Document Hash:** c7288a3942c652097dc65083d0e66932
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000000000-25-006255.hdr.sgml**: 20250724

**ACCESSION NUMBER**: 0000000000-25-006255

**CONFORMED SUBMISSION TYPE**: UPLOAD

**PUBLIC DOCUMENT COUNT**: 2

**FILED AS OF DATE**: 20250613

**FILED FOR**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** NuCana plc
- **CENTRAL INDEX KEY:** 0001709626
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** X0
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** UPLOAD
- **SEC FILE NUMBER:** 333-281576

**BUSINESS ADDRESS:**
- **STREET 1:** 3 LOCHSIDE WAY
- **CITY:** EDINBURGH
- **STATE:** X0
- **ZIP:** EH12 9DT
- **BUSINESS PHONE:** 44-0-131-357-1111

**MAIL ADDRESS:**
- **STREET 1:** 3 LOCHSIDE WAY
- **CITY:** EDINBURGH
- **STATE:** X0
- **ZIP:** EH12 9DT

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** NuCana BioMed Ltd
- **DATE OF NAME CHANGE:** 20170619
**PUBLIC REFERENCE ACCESSION NUMBER**: 0001193125-24-201347

## Text-Extract

```

                                                             June 13, 2025

CERTIFIED MAIL
RETURN RECEIPT REQUESTED

Hugh S. Griffith
Chief Executive Officer
NuCana plc
3 Lochside Way
Edinburgh, EH12 9DT
United Kingdom

        Re: NuCana plc
            Registration Statement on Form F-3
            Filed August 15, 2024
            File No. 333-281576
Dear Hugh S. Griffith:

      It has been more than nine months since you filed this registration
statement and it is
now out of date. Within 30 days from the date of this letter, you should
either:

      amend it to comply with the applicable requirements of the Securities Act
of 1933, the
    rules and regulations under the Act, and the requirements of the form; or
      file a request for withdrawal.
       If you requested confidential treatment for portions of any exhibits to
your registration
statement and you request withdrawal of that registration statement, please
submit a
concurrent request for withdrawal of your application for confidential
treatment.

       If you do not amend the registration statement or file a request for
withdrawal (or
provide us with a satisfactory explanation of why you have not done either)
within 30 days,
we may enter an order declaring the registration statement abandoned under rule
479 of the
Act.

        Please contact Chris Edwards at 202-551-6761 with any questions.

                                                             Sincerely,
 June 13, 2025
Page 2

                                    Division of Corporation Finance
                                    Office of Life Sciences

cc:   Corporation Service Company
      CERTIFIED MAIL
      RETURN RECEIPT REQUESTED

```

### Attached PDF Documents

**Attachment 1:** `filename1`

_No text found in this document._