# EDGAR Filing Document

**Accession Number:** 0001357874
**File Stem:** 0001628280-26-003146
**Filing Date:** 2026-1
**Character Count:** 7985
**Document Hash:** eef23e5924822390abc84d87d3f05b91
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001628280-26-003146.hdr.sgml**: 20260122

**ACCESSION NUMBER**: 0001628280-26-003146

**CONFORMED SUBMISSION TYPE**: 4

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20260120

**FILED AS OF DATE**: 20260122

**DATE AS OF CHANGE**: 20260122

**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** SMITH J. JEFFERSON
- **CENTRAL INDEX KEY:** 0001770169

**ORGANIZATION NAME:**

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-38841
- **FILM NUMBER:** 26552867

**MAIL ADDRESS:**
- **STREET 1:** C/O PRECISION BIOSCIENCES, INC.
- **STREET 2:** 302 EAST PETTIGREW STREET, SUITE A-100
- **CITY:** DURHAM
- **STATE:** NC
- **ZIP:** 27701
**ISSUER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** PRECISION BIOSCIENCES INC
- **CENTRAL INDEX KEY:** 0001357874
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**BUSINESS ADDRESS:**
- **STREET 1:** 302 EAST PETTIGREW STREET
- **STREET 2:** SUITE A-100
- **CITY:** DURHAM
- **STATE:** NC
- **ZIP:** 27701
- **BUSINESS PHONE:** 919-314-5512

**MAIL ADDRESS:**
- **STREET 1:** 302 EAST PETTIGREW STREET
- **STREET 2:** SUITE A-100
- **CITY:** DURHAM
- **STATE:** NC
- **ZIP:** 27701

### UNITED STATES SECURITIES AND EXCHANGE COMMISSION
**Washington, D.C. 20549**

## FORM 4

### STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

[x] Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>SMITH J. JEFFERSON<br><sub>(Last) (First) (Middle)</sub><br>C/O PRECISION BIOSCIENCES, INC.<br>302 E. PETTIGREW STREET, SUITE A-100<br><sub>(Street)</sub><br>DURHAM, NC 27701<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2026-01-20 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[ ] Director [ ] 10% Owner<br>[X] Officer (give title below) [ ] Other (specify below)<br>_Chief Research Officer_ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>PRECISION BIOSCIENCES INC [ DTIL ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[X] Form filed by One Reporting Person<br>[ ] Form filed by More than One Reporting Person |

---

## Table I - Non-Derivative Securities

---

|  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1. Title of Security | 2. Transaction Date | 2A. Deemed Execution Date | 3. Transaction Code (V) | 3. Transaction Code (V) | 4. Securities Acquired (A) or Disposed of (D) | 4. Securities Acquired (A) or Disposed of (D) | 4. Securities Acquired (A) or Disposed of (D) | 5. Amount of Securities Beneficially Owned | 6. Ownership Form | 7. Nature of Indirect Beneficial Ownership |
| 1. Title of Security | 2. Transaction Date | 2A. Deemed Execution Date | Code | V | Amount | (A) or (D) | Price | 5. Amount of Securities Beneficially Owned | 6. Ownership Form | 7. Nature of Indirect Beneficial Ownership |
| Common Stock | 2026-01-20 |  | M |  | 2500<sup>(1)</sup> | A | <sup>(2)</sup> | 93718<sup>(3)</sup> | D |  |
| Common Stock | 2026-01-20 |  | M |  | 10447<sup>(1)</sup> | A | <sup>(2)</sup> | 104165 | D |  |
| Common Stock | 2026-01-21 |  | M |  | 16219<sup>(1)</sup> | A | <sup>(2)</sup> | 120384 | D |  |
| Common Stock | 2026-01-21 |  | S<sup>(4)</sup> |  | 10200 | D | $4.03 | 110184 | D |  |
| Common Stock |  |  |  |  |  |  |  | 7931 | I | By Charitable Remainder Unitrust |

---

## Table II - Derivative Securities

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1. Title of Derivative Security | 2. Conversion or Exercise Price | 3. Transaction Date | 3A. Deemed Execution Date | 4. Transaction Code (V) | 4. Transaction Code (V) | 5. Number of Derivative Securities Acquired (A) or Disposed of (D) | 5. Number of Derivative Securities Acquired (A) or Disposed of (D) | 6. Date Exercisable and Expiration Date | 6. Date Exercisable and Expiration Date | 7. Title and Amount of Underlying Securities | 7. Title and Amount of Underlying Securities | 8. Price of Derivative Security | 9. Number of Derivative Securities Beneficially Owned | 10. Ownership Form | 11. Nature of Indirect Beneficial Ownership |
| 1. Title of Derivative Security | 2. Conversion or Exercise Price | 3. Transaction Date | 3A. Deemed Execution Date | Code | V | (A) | (D) | Date Exercisable | Expiration Date | Title | Amount or Number of Shares | 8. Price of Derivative Security | 9. Number of Derivative Securities Beneficially Owned | 10. Ownership Form | 11. Nature of Indirect Beneficial Ownership |
| Restricted Stock Units | <sup>(2)</sup> | 2026-01-20 |  | M |  |  | 2500 | <sup>(5)</sup> | <sup>(5)</sup> | Common Stock | 2500 | $0 | 0 | D |  |
| Restricted Stock Units | <sup>(2)</sup> | 2026-01-20 |  | M |  |  | 10447 | <sup>(6)</sup> | <sup>(6)</sup> | Common Stock | 10447 | $0 | 10447 | D |  |
| Restricted Stock Units | <sup>(2)</sup> | 2026-01-20 |  | M |  |  | 16219 | <sup>(7)</sup> | <sup>(7)</sup> | Common Stock | 16219 | $0 | 16219 | D |  |

---

### Footnotes:

(1) Represents the vesting of Restricted Stock Units ("RSUs") on January 20, 2026.

(2) Each RSU represents a contingent right to receive one share of the Issuer's Common Stock.

(3) Includes 3,413 shares acquired under the Issuer's 2019 Employee Stock Purchase Plan at a weighted average price per share of $5.74

(4) The sales were effected pursuant to a Rule 10b5-1 plan adopted on April 25, 2024. The transaction was a sell-to-cover, with shares only sold to cover tax withholding obligations in connection with the vesting and settlement of RSUs. The Reporting Person did not sell or otherwise dispose of shares reported on this Form 4 for any reason other than to cover required taxes and fees.

(5) On January 20, 2023 the Reporting Person was granted RSUs, which vested in three substantially equal annual installments beginning on January 20, 2024, subject to the Reporting Person's continued service to the Issuer through the applicable vesting dates.

(6) On April 18, 2024 the Reporting Person was granted RSUs, which vest in three substantially equal annual installments beginning on January 20, 2025, subject to the Reporting Person's continued service to the Issuer through the applicable vesting dates.

(7) On August 22, 2024 the Reporting Person was granted RSUs, which vest in three substantially equal annual installments beginning on January 20, 2025, subject to the Reporting Person's continued service to the Issuer through the applicable vesting dates.

**Signature:** /s/ Dario Scimeca Attorney-in-fact for Jeff Smith  
**Date:** 2026-01-22

### Remarks:

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

**Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.**