# EDGAR Filing Document

**Accession Number:** 0001837607
**File Stem:** 0001104659-23-025348
**Filing Date:** 2023-2
**Character Count:** 36844
**Document Hash:** ca753adc81738429b629c8ff953aff0d
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-23-025348.hdr.sgml**: 20230224

**ACCESSION NUMBER**: 0001104659-23-025348

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 55

**CONFORMED PERIOD OF REPORT**: 20230224

**ITEM INFORMATION**: Regulation FD Disclosure

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20230224

**DATE AS OF CHANGE**: 20230224

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Priveterra Acquisition Corp.
- **CENTRAL INDEX KEY:** 0001837607
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 853940478
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-40021
- **FILM NUMBER:** 23668171

**BUSINESS ADDRESS:**
- **STREET 1:** 300 SE 2ND STREET
- **STREET 2:** SUITE 600
- **CITY:** FORT LAUDERDALE
- **STATE:** FL
- **ZIP:** 33301
- **BUSINESS PHONE:** (407) 808-1335

**MAIL ADDRESS:**
- **STREET 1:** 300 SE 2ND STREET
- **STREET 2:** SUITE 600
- **CITY:** FORT LAUDERDALE
- **STATE:** FL
- **ZIP:** 33301

?xml version="1.0" encoding="utf-8"?

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

 **Washington, D.C. 20549**

**FORM 8-K**

**CURRENT REPORT**

**PURSUANT TO SECTION 13 OR 15(d) OF THE**

**SECURITIES EXCHANGE ACT OF 1934**

Date of Report (Date of earliest event reported): **February 24, 2023**

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**PRIVETERRA ACQUISITION CORP.**

(Exact name of registrant as specified in its charter)

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| | | |
|:---|:---|:---|
| **Delaware** | **001-40021** | **85-3940478** |
| (State or other jurisdiction of<br> incorporation) | (Commission<br> File Number) | (IRS Employer<br> Identification No.) |

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**300 SE 2nd Street, Suite 600**

**Fort Lauderdale, Florida 33301**

(Address of principal executive offices, including zip code)

Registrant's telephone number, including area code: **(754) 220-9229**

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| |
|:---|
| **Not Applicable** |
| (Former name or former address, if changed since last report) |

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Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

⌧ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

◻ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

◻ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

◻ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ⌧

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻

Securities registered pursuant to Section 12(b) of the Act:

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| | | |
|:---|:---|:---|
| **Title of each class** | **Trading<br> Symbol(s)** | **Name of each exchange on which <br> registered** |
| **Units, each consisting of one share of Class A common stock and one-third of one redeemable warrant** | **PMGMU** | **The Nasdaq Stock Market LLC** |
| **Class A common stock, par value $0.0001 per share** | **PMGM** | **The Nasdaq Stock Market LLC** |
| **Redeemable warrants, each warrant exercisable for one share of Class A common stock at an exercise price of $11.50** | **PMGMW** | **The Nasdaq Stock Market LLC** |

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**Item 7.01** **Regulation FD Disclosure.** 

On February 14, 2023, AEON Biopharma, Inc. ("AEON") filed on this Current Report on Form 8-K stating that AEON issued a press release announcing that AEON will host a key opinion leader webinar on the past, present, and potential future treatments for migraine using botulinum toxin on Friday, February 24, 2023 at 11:00 a.m. Eastern Time (the "Webinar").

On February 24, 2023, AEON published the final presentation from the Webinar. A copy of the final presentation is furnished hereto as Exhibit 99.1.

The information in this Item 7.01, including Exhibit 99.1, is furnished and shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "<u>Exchange Act</u>"), or otherwise subject to liabilities under that section, and shall not be deemed to be incorporated by reference into the filings of PMGM under the Securities Act of 1933, as amended (the "<u>Securities Act</u>") or the Exchange Act, regardless of any general incorporation language in such filings. This Current Report on Form 8-K will not be deemed an admission as to the materiality of any information of the information contained in this Item 7.01, including Exhibit 99.1.

**Item 9.01 Financial Statements and Exhibits.**

(d) Exhibits

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| | |
|:---|:---|
| **Exhibit<br> No.** | **Description** |
| [99.1](tm237816d1_ex99-1.htm) | [Final Presentation, dated February 24, 2023](tm237816d1_ex99-1.htm) |
| 104 | Cover Page Interactive Data File (embedded within the Inline XBRL document) |

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**SIGNATURE**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

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| | |
|:---|:---|
| **Priveterra Acquisition Corp.** | **Priveterra Acquisition Corp.** |
| By: | /s/ Robert J. Palmisano |
| Name: | Robert J. Palmisano |
| Title: | Chairman and Chief Executive Officer |

---

Dated: February 24, 2023

## Exhibit 99.1

**Exhibit 99.1**

![](tm237816d1_ex99-1img001.jpg)

KOL EVENT: Botulinum Toxin and Migraine Prevention February 24, 2023

![](tm237816d1_ex99-1img002.jpg)

Disclaimer 2 About This Presentation This investor presentation ("Presentation") does not constitute (i) a solicitation of a proxy, consent or authorization with respect to any securities or in respect of the proposed Business Combination or (ii) an offer to sell, a solicitation of an offer to buy, or a recommendation to purchase any security of Priveterra, the Company, or any of their respective affiliates . No such offering of securities shall be made except by means of a prospectus meeting the requirements of section 10 of the Securities Act of 1933 , as amended . Forward Looking Statements Certain statements, estimates, targets and projections in this Presentation may be considered forward - looking statements. Forward - looking statements generally relate to future events or involving, or future performance of, Priveterra Acquisition Corp. ("Priveterra") or AEON Biopharma, Inc. (the "Company"). For example, projections of future EBITDA, statements regarding anticipated growth in the industry in which the Company operates and anticipated growth in demand for the Company's products, projections of the Company's future financial results and other metrics, the satisfaction of closing conditions to the pending business combination between Priveterra and the Company (the "Business Combination") and the timing of the completion of the Business Combination are forward - looking statements. In some cases, you can identify forward - looking statements by terminology such as "pro forma", "may", "should", "could", "might", "plan", "possible", "project", "strive", "budget", "forecast", "expect", "intend", "will", "estimate", "anticipate", "believe", "predict", "potential" or "continue", or the negatives of these terms or variations of them or similar terminology. Such forward - looking statements are subject to risks, uncertainties, and other factors which could cause actual results to differ materially from those expressed or implied by such forward - looking statements. These forward - looking statements are based upon estimates and assumptions that, while considered reasonable by Priveterra and its management, and the Company and its management, as the case may be, are inherently uncertain. Factors that may cause actual results to differ materially from current expectations include, but are not limited to: (i) the occurrence of any event, change or other circumstances that could give rise to the termination of negotiations and any subsequent definitive agreements with respect to the Business Combination; (ii) the outcome of any legal proceedings that may be instituted against Priveterra, the Company, the combined company or others following the announcement of the Business Combination and any definitive agreements with respect thereto; (iii) the inability to complete the Business Combination due to the failure to obtain approval of the stockholders of Priveterra or the Company or to satisfy other conditions to closing; (iv) changes to the proposed structure of the Business Combination that may be required or appropriate as a result of applicable laws or regulations or as a condition to obtaining regulatory approval of the Business Combination; (v) the ability to meet stock exchange listing standards following the consummation of the Business Combination; (vi) the risk that the Business Combination disrupts current plans and operations of the Company as a result of the announcement and consummation of the Business Combination; (vii) the ability to recognize the anticipated benefits of the Business Combination, which may be affected by, among other things, the ability to identify, develop and commercialize product candidates, the initiation, cost, timing, progress or results of current or planned preclinical studies and clinical trials, product acceptance and/or receipt of regulatory approvals for product candidates, including related milestones, the plans, strategies and objectives of management for future operations, the beliefs and assumptions of management regarding future events, potential markets or market size, or technological developments, competition and advancement of research and development activities in the biopharma industry, the ability of the combined company to grow and manage growth profitably, maintain relationships with suppliers and retain its management and key employees, costs related to the Business Combination, changes in applicable laws or regulations, the possibility that the Company or the combined company may be adversely affected by other economic, business, regulatory, and/or competitive factors; the Company's estimates of expenses and profitability, the evolution of the markets in which the Company competes, the ability of the Company to implement its strategic initiatives and continue to innovate its existing product candidates, the ability of the Company to defend its intellectual property and satisfy regulatory requirements, the impact of the COVID - 19 pandemic on the Company's business; and (viii) other risks and uncertainties set forth in the section entitled "Risk Factors" and "Cautionary Note Regarding Forward - Looking Statements" in Priveterra's final prospectus dated February 11, 2021, relating to its initial public offering and other risks and uncertainties indicated from time to time in the definitive proxy statement to be delivered to Priveterra's stockholders and related registration statement on Form S - 4, including those set forth under "Risk Factors" therein, and other documents to be filed with the SEC by Priveterra . Nothing in this Presentation should be regarded as a representation by any person that the forward - looking statements set forth herein will be achieved or that any of the contemplated results of such forward - looking statements will be achieved. You should not place undue reliance on forward - looking statements, which speak only as of the date they are made. Neither Priveterra nor the Company undertakes any duty to update these forward - looking statements.

![](tm237816d1_ex99-1img003.jpg)

Disclaimer (Cont'd) 3 Targets This Presentation contains certain long - term financial targets of the Company. Neither Priveterra's nor the Company's independent auditors have audited, studied, reviewed, compiled or performed any procedures with respect to the targets for the purpose of their inclusion in this Presentation, and accordingly, they did not express an opinion or provide any other form of assurance with respect thereto for the purpose of this Presentation. These targets are forward - looking statements and should not be relied upon as being necessarily indicative of future results. The assumptions and estimates underlying these targets are inherently uncertain and are subject to a wide variety of significant business, economic and competitive risks and uncertainties that could cause actual results to differ materially from the targets. Accordingly, there can be no assurance that these targets are indicative of the future performance of the Company or that actual results will not differ materially from those presented. Inclusion of the targets in this Presentation should not be regarded as a representation by any person that the targets will be achieved. Industry and Market Data In this Presentation, the Company relies on and refers to certain information and statistics obtained from third - party sources which it believes to be reliable. Neither Priveterra nor the Company has independently verified the accuracy or completeness of any such third - party information. Trademarks This Presentation may contain trademarks, service marks, trade names and copyrights of other companies, which are the property of their respective owners. Solely for convenience, some of the trademarks, service marks, trade names and copyrights referred to in this Presentation may be listed without the TM, SM,© or® symbols, but Priveterra and the Company will assert, to the fullest extent under applicable law, the rights of the applicable owners, if any, to these trademarks, service marks, trade names and copyrights. Additional Information On December 27, 2022, Priveterra initially filed a registration statement on Form S - 4 with the Securities and Exchange Commission (the "SEC"), which includes a proxy statement/prospectus, that will be both the proxy statement to be distributed to holders of Priveterra's Class A common stock in connection with its solicitation of proxies for the vote by Priveterra's stockholders with respect to the Business Combination and other matters as may be described in the registration statement, as well as the prospectus relating to the offer and sale of the securities to be issued in the Business Combination. After the registration statement is declared effective, Priveterra will mail a definitive proxy statement/prospectus and other relevant documents to its stockholders. This Presentation does not contain all the information that should be considered concerning the proposed Business Combination and is not intended to form the basis of any investment decision or any other decision in respect of the Business Combination. Priveterra's stockholders and other interested persons are advised to read, the preliminary proxy statement/prospectus included in the registration statement and the amendments thereto and the definitive proxy statement/prospectus and other documents filed in connection with the proposed Business Combination, as these materials contain important information about the Company, Priveterra and the Business Combination. T he definitive proxy statement/prospectus and other relevant materials for the proposed Business Combination will be mailed to stockholders of Priveterra as of a record date to be established for voting on the proposed Business Combination. Stockholders are also able to obtain copies of the preliminary proxy statement, the definitive proxy statement and other documents filed with the SEC, without charge at the SEC's website at www.sec.gov, or by directing a request to Priveterra's secretary at 300 SE 2nd Street, Suite 600, Fort Lauderdale, Florida 33301, 754 - 220 - 9229. Participants in the Solicitation Priveterra and its directors and executive officers may be deemed participants in the solicitation of proxies from Priveterra's stockholders with respect to the proposed Business Combination. A list of the names of those directors and executive officers and a description of their interests in Priveterra is contained in Priveterra's prospectus dated February 11, 2021 relating to its initial public offering, which was filed with the SEC and is available free of charge at the SEC's website at www.sec.gov. To the extent such holdings of Priveterra's securities may have changed since that time, such changes have been reflected on Statements of Change in Ownership on Form 4 filed with the SEC. Additional information regarding the interests of such participants is contained in the proxy statement/prospectus for the proposed Business Combination . The Company and its directors and executive officers may also be deemed to be participants in the solicitation of proxies from the stockholders of Priveterra in connection with the proposed Business Combination. A list of the names of such directors and executive officers and information regarding their interests in the proposed Business Combination will be included in the proxy statement/prospectus for the proposed Business Combination.

![](tm237816d1_ex99-1img004.jpg)

Agenda Migraine Overview and Current Treatment Landscape – Stewart J. Tepper, MD ABP - 450 Clinical Program in Migraine – Chad Oh, MD (Chief Medical Officer) Fireside Chat and Q&A Session – Moderated by Corey Davis (LifeSci Advisors) I Opening and Introduction – Marc Forth (President & Chief Executive Officer) The Benefits of a New Injection Paradigm – Andrew M. Blumenfeld, MD 1 II III IV V 4

![](tm237816d1_ex99-1img005.jpg)

5 Speakers Stewart J. Tepper, MD Stewart J . Tepper, MD is a Professor of Neurology at the Geisel School of Medicine at Dartmouth College in Hanover, New Hampshire . He is Director of the Dartmouth Headache Center in the Department of Neurology of Dartmouth - Hitchcock Medical Center . Dr . Tepper was Director of the Scottsdale Headache Symposium CME course of the American Headache Society from 2008 to 2020 . He was Editor - in - Chief of the journal Headache Currents and Associate Editor for the journal Headache from 2012 - 2020 . He has published more than 470 peer - reviewed manuscripts, editorials, and books on Headache Medicine . Dr . Tepper serves on the Executive Board of Directors and is the Corporate Liaison for the American Headache Society . He serves on the AHS Education, Exhibits, and Finance Committees . He also serves on the Governance Committee and Board of Directors of the American Migraine Foundation . Dr . Tepper received his undergraduate degree cum laude in the study of the nervous system/psychobiology from Yale College and attended Cornell University Medical College . He completed his Neurology residency at the Longwood Area Harvard program and has been board certified in Headache Medicine since 2006 .

![](tm237816d1_ex99-1img006.jpg)

6 Speakers Andrew M. Blumenfeld, MD Andrew M . Blumenfeld, MD is Director of : The Los Angeles Headache Centre with offices in San Diego and Los Angeles . He is Board - certified in Neurology by the American Board of Psychiatry and Neurology and is also certified in Headache Medicine . Dr Blumenfeld is a member and fellow of both the American Academy of Neurology and the American Headache Society . He is the founding chair of the American Headache Society section on Interventional Procedures for Headache . He has published widely and has over 100 publications . One of his manuscripts was voted the top publication in the Headache journal . His research interests have focused on the use of Botox for migraine . He helped to develop the injection protocol used in the pivotal migraine trials . He teaches other providers on this procedure nationally and internationally . He has been an active researcher in headache with 26 issued patents for various treatments . He consults with numerous pharmaceutical companies involved with medications related to headache disorders, and more details can be found through The Sunshine Act .

![](tm237816d1_ex99-1img007.jpg)

Source: 1. Decision Resources Group Therapeutic Botulinum Toxin Market Analysis Global 2021 7 Advancing Novel Therapies with a Well - Established Neurotoxin Management team with significant neurotoxin and biopharma experience Differentiated business model designed to deliver enhanced value to payors and providers An estimated $3.0B global therapeutic neurotoxin market projected to grow to $4.4B in 2027 1 AEON has a differentiated business model for a platform product candidate ABP - 450 Same 900 kDa Neurotoxin Complex Approved for Pipeline in a Product candidate; Aesthetic Indications three clinical development programs and one preclinical program - in chronic conditions

![](tm237816d1_ex99-1img008.jpg)

Sources: 1. Bonafede, Study Summary: Costs Associated with Migraine in the US (2018) 8 Migraine Market is Large with Continued Need for Additional Therapies Patient Burden • Migraine is a complex neurological condition that affects ~ 40 million Americans every year , with the majority of sufferers being women • Migraine sufferers experience symptoms such as nausea, vomiting, pain and sensitivity to light, leading to ~36 billion healthcare and lost productivity costs annually Significant unmet needs • Migraine is underdiagnosed and undertreated due to factors such as awareness, access to healthcare, and misdiagnosis • The discontinuation rate for patients on existing oral preventive migraine medications is high due to poor tolerability and lack of efficacy Addressable Market • Of the expected 40 million adult migraine patients in the US in 2020, 3.7 million are diagnosed with high - frequency and chronic migraines • Of the 3.7 million diagnosed high - frequency and chronic migraine patients, 1.1 million currently receive preventive treatment Botulinum toxin injections are a safe and efficacious preventive treatment option for patients that suffer from migraines

![](tm237816d1_ex99-1img009.jpg)

Sources: 1 . 2017 US Census Projections 2. Burch, The Prevalence and Impact of Migraine and Severe Headache in the United States: Figures and Trends From Government Hea lth Studies (2018); 3. Lipton, Migraine in America Symptoms and Treatment (MAST) Study: Baseline Study Methods, Treatment Patterns, and Gender Differences (2018) ; 4. Buse, Impact of Migraine on the Family: Perspectives of People With Migraine and Their Spouse/Domestic Partner in the CaMEO Study (2016) 5. Diamond, Patterns of Diagnosis and Acute and Preventive Treatment for Migraine in the United States: Results from the America n M igraine Prevalence and Prevention Study (2006); 6. Messali , Direct and Indirect Costs of Chronic and Episodic Migraine in the United States: A Web - Based Survey (2016) 9 Approximately 13.4M Patients Living with 6+ Headaches/Month in U.S. Alone 260M People Projected 2020 US 18+ Population 1 40M Patients (15%) Estimated Migraine and severe HA Patients 9.4M Patients (24%) Episodic Migraine (6 - 14 HA/month) 4.0M Patients (10%) Chronic Migraine (15+ HA/month) 2.2M Patients (56%) Diagnosed Prevalence 3.7M Patients (39%) Diagnosed Prevalence 820k Patients (37%) Treated Patients (Prophylactic) 740k Patients (20%) Treated Patients (Prophylactic) 1.6M Total Addressable Patients Chronic Migraine Episodic Migraine

![](tm237816d1_ex99-1img010.jpg)

Chronic (>15 headache days AND >8 migraine days / month) Episodic (<15 headache days AND 6 - 14 migraine days / month) Asterisk in dicates phase is complete 10 Development Timeline Includes Multiple Clinical Near - Term Milestones Chronic Migraine Episodic Migraine Indication Current Phase ABP - 450 Cervical Dystonia Phase 2 Phase 2 Phase 2\* 1 2 3 1 1) IND accepted Oct 2020 2) First patient treated Mar 2021 3) Anticipate to complete episodic enrollment Q4 2022 4) Anticipate P2 top line episodic data 2H 2023 1 2 3 4 2 3 4 1) IND accepted Oct 2020 2) First patient treated Mar 2021 3) Anticipate P2 top line chronic data 2024 1) IND accepted Sep 2020 2) First patient treated Apr 2021; last patient last visit Jul 2022 3) P2 data reported Sep 2022 4) Anticipate P3 initiation in 2024 Expected Cost $25M to $35M $1M to $5M 2020 2021 2022 2023 2024 1H 2H 1H 2H 1H 2H 1H 2H 1H 2H

![](tm237816d1_ex99-1img011.jpg)

Migraine Overview and Current Treatment Landscape Stewart J. Tepper, MD

![](tm237816d1_ex99-1img012.jpg)

Stewart J. Tepper , MD Areas of Need in Neurotoxin Therapy for Migraine - The Opportunities for Aeon Stewart J. Tepper, MD, FAHS Professor of Neurology Geisel School of Medicine at Dartmouth Hanover, New Hampshire, USA

![](tm237816d1_ex99-1img013.jpg)

Stewart J. Tepper , MD Introduction • There are numerous areas of need in migraine prevention • Neurotoxins address many of these needs • There is an opportunity for new neurotoxins with new indications

![](tm237816d1_ex99-1img014.jpg)

Stewart J. Tepper , MD Case • 27 year old woman with disabling high frequency episodic migraine, (EM) with 10 - 12 significant headache days per month • She says there are months that are worse and months where she is better, higher and lower frequencies of monthly headache days • For prevention she has tried amitriptyline (too sedating), topiramate (cognitive impairment), and propranolol (lightheaded) • She is very leery of Botox because of 31 injections and what "she has heard about it" • Her provider tells her she is not eligible for Botox anyway, because she has EM, less than 15 headache days per month, not chronic migraine (CM) at least 15 headache days per month

![](tm237816d1_ex99-1img015.jpg)

Stewart J. Tepper , MD The Artificiality of Episodic and Chronic Migraine Definitions

![](tm237816d1_ex99-1img016.jpg)

Stewart J. Tepper , MD Chronic Migraine (CM), ICHD3 Criteria and New Proposed CM Criteria • Headache ≥15 days/month for >3 months • ≥5 previous migraine attacks (link to EM) • ≥8 days/month for >3 months: • Meet criteria for migraine • Believed by the patient to be migraine at onset and relieved by triptan or ergot • Not better accounted for by another ICHD - 3 diagnosis (Not secondary) ICHD - 3. Cephalalgia 2013; 33(9) 629 – 808. Chronic Migraine, ICHD3 Chalmer et al. Cephalalgia . 2020 Apr;40(4):399 - 406. Proposed Criteria for Chronic Migraine

![](tm237816d1_ex99-1img017.jpg)

Stewart J. Tepper , MD The Roller Coaster of EM and CM Patient has some months with Chronic Migraine [CM] (headache ≥15 days per month) Patient has some months with High Frequency Episodic Migraine [HFEM] (headache 10 - 14 days per month) ICHD - 3. Cephalalgia 2013; 33(9) 629 – 808 . Serrano et al. The Journal of Headache and Pain 2017;18:101. CaMEO Study This patient

![](tm237816d1_ex99-1img018.jpg)

Stewart J. Tepper , MD Problem #1: She is ineligible for Botox • The provider told her she is ineligible for Botox because it is only approved for CM, and she has EM as her diagnosis • In reality, she is probably yo - yoing up and down between EM and CM, but that does not help • Botox is indicated only for CM prevention, and Nurtec and Qulipta are only indicated for EM prevention • Depending on the month surveyed, she will be ineligible for two categories of anti - migraine preventive therapy

![](tm237816d1_ex99-1img019.jpg)

Stewart J. Tepper , MD Solution for Problem #1 • Aeon is studying ABP - 450, prabotulinumtoxinA , for both EM and CM in their randomized controlle d trial • This will offer an indication for prevention of all of migraine, both EM and CM • This will allow its use for this patient and many more, especially given the Roller Coaster of headache day frequency seen in the migraine population

![](tm237816d1_ex99-1img020.jpg)

Stewart J. Tepper , MD Inadequate , Partial Response to Anti - CGRP Therapy Monoclonal Antibodies

![](tm237816d1_ex99-1img021.jpg)

Stewart J. Tepper , MD Problem #2 • The patient was put on an anti - CGRP therapy monoclonal antibody (MAB) • These are approved for all migraine, EM and CM • But she only had a reduction of - 3 days, going from 11 headache days per month to 8, leaving her with two significant headache days per week and significant disability • What can be done next?

![](tm237816d1_ex99-1img022.jpg)

Stewart J. Tepper , MD Solution • Combination of neurotoxin + anti - CGRP therapy MABs is at least additive and can be synergistic • Hundreds of patients have been reported in large case series showing additional benefit from the combination, in which combining the two medication categories improve outcomes by different but complimentary mechanisms of action • This patient is ineligible for Botox, but would be eligible for the addition of ABP - 450 with the planned indication for both EM and CM Blumenfeld et al. Pain Ther . 2021;10:809 - 826. Cohen et al. Pain Med. 2021;22:1857 - 1863. Nandyala et al. Clin Neurol Neurosurg . 2022;215:107200. Ailani and Blumenfeld. Headache . 2022;62:106 - 108.

![](tm237816d1_ex99-1img023.jpg)

Stewart J. Tepper , MD The EM Problem

![](tm237816d1_ex99-1img024.jpg)

Stewart J. Tepper , MD The EM Problem • The problem of migraine prevention for a disabled EM patient is significant • The prevalence of EM in the population is 12%; the prevalence of CM is 1 - 2%, so the numbers suggest a significant unmet need

![](tm237816d1_ex99-1img025.jpg)

Stewart J. Tepper , MD Protocol Improvement

![](tm237816d1_ex99-1img026.jpg)

Stewart J. Tepper , MD Less injections, better protocol • My colleagues will describe the improved protocol for ABP - 450 • Suffice it to say, this should address the patient's concern about 31 injections and side effects reported with Botox in the pivotal trials

![](tm237816d1_ex99-1img027.jpg)

Stewart J. Tepper , MD Summary : Unmet Needs May Be Met with ABP - 450

![](tm237816d1_ex99-1img028.jpg)

Stewart J. Tepper , MD Summary of Unmet Needs in Migraine Prevention • Patients need a neurotoxin migraine prevention with an indication for all of migraine, both EM and CM • The up and down frequency of migraine results in unpredictability and limits migraine preventive therapy availability • Patients need a neurotoxin with applicability to their clinical migraine situation • When a preventive therapy yields suboptimal improvement, patients need to be able to add a neurotoxin with wide indications • For patients who want less than 31 injections quarterly, a better protocol is aspirational • The hope is that Aeon's ABP - 450, prabotulinumtoxinA , will address every one of these unmet needs

![](tm237816d1_ex99-1img029.jpg)

Stewart J. Tepper , MD Thank you!

![](tm237816d1_ex99-1img030.jpg)

The Benefits of a New Injection Paradigm Andrew M. Blumenfeld, MD

![](tm237816d1_ex99-1img031.jpg)

Anterior / Lateral Injection Sites 31

![](tm237816d1_ex99-1img032.jpg)

Posterior Injection Sites 32

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Tolerability parameter (% of pts) Pooled PREEMPT studies [ 15 ] COMPEL [ 16 ] REPOSE [ 38 ] CM - PASS [ 51 ] ABP - 450 (EM) ABP - 450 (CM) DB OLE OL OL OL DB DB BoNT/A (n = 687) PL (n = 692) BoNT/A (n = 1205) BoNT/A (n = 716) BoNT/A (n = 633) BoNT /A (n = 1160) TEAEs 62.4\*\* 51.7 58.3 60.9 – 41.2 Serious TEAEs 4.8\* 2.3 3.8 10.5 – 5.3 TRAEs a 29.4\*\* 12.7 20.3 18.3 18.3 25.1 Serious TRAEs a 0.1 0.0 0.1 0.1 1.3 < ௗ 0.1 Common TRAEs a Blinded Data ABP - 450 data (as of Feb 10, 2023) Neck pain 6.7 2.2 4.6 4.1 2.8 4.4 2 (4/190 completers) 1.5 (2/128 completers) Muscular weakness 5.5 0.3 3.9 1.4 – 2.7 0 0 Eyelid ptosis 3.3 0.3 2.5 2.5 5.4 4.1 0 0 Injection site pain 3.2 2.0 2.0 2.0 – – Headache 2.9 1.6 1.4 1.4 – 2.2 Myalgia 2.6 0.3 1.2 – – 0.9 Musculoskeletal stiffness 2.3 0.7 1.7 1.7 2.7 2.0 Musculoskeletal pain 2.2 0.7 1.1 – – 0.9 Facial paresis 2.2 b – 1.2 b 1.3 – 1.3 Discontinuations due to AEs 3.8 c 1.2 c 2.6 c 4.5 c (1.8 d) 1.6 d 4.4 c AEs adverse events, ADR adverse drug reactions, BoNT /A onabotulinumtoxinA (Botox®), DB double - blind phase, OL(E) open - label (extension phase), PL placebo, pts patients, TEAEs treatment - emergent AEs, TRAEs treatment - related AEs, – information not available (e.g. only ADRs occurring in > ௗ 2% of pts in REPOSE were reported). \* p = 0.0133, \*\* p < 0.0001 vs PL a ADRs (REPOSE) b Included in muscular weakness in PREEMPT 1 and 2 c Discontinuations due to TEAEs d Discontinuations due to TRAEs Tolerability of Botox® and ABP - 450 in EM and CM 33

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ABP - 450 Clinical Program in Migraine Chad Oh, MD Chief Medical Officer

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• N = 765 • ~60 sites in US, Canada & Australia • Includes both EM & CM patients • # headache days and migraine days/month established during 4 - week baseline prior to randomization • 3 arms: 150 Units, 195 Units, PBO • 2 injection cycles, 3 months apart • 6 - month treatment duration • Novel injection paradigm: - 22 injection sites (ABP - 450) - vs. 31 injections for Botox Primary: • Mean change of monthly migraine days (MMD) at Week 24 • Incidence of TEAEs throughout study compared to placebo Secondary: • Percentage of patients with reduction from baseline of ≥50%, 75%, 100% in average number of MMD throughout the study • Change in use of rescue medications from baseline • Safety endpoints of change in laboratory tests, ECG, etc. Exploratory: • Change in PGI - S, PGI - C, MIDAS, etc. Placebo n= 255 195 Units ABP - 450 n= 255 28 weeks Primary Efficacy Endpoint 150 Units ABP - 450 n= 255 4 - week Baseline 4 - week Screening Randomized R Endpoints Randomized Double - Blinded Placebo - Controlled Study Open Label Extension Study 4 treatments of ABP - 450 52 weeks Study Design 12 weeks Phase 2 Design: Episodic Migraine (EM) and Chronic Migraine (CM)

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36 Independent Analysis of Phase 2 Episodic and Chronic Cohorts Randomization and Stratified for Episodic Migraine and Chronic Migraine Episodic Migraine N=300 <15 headache days / month And 6 - 14 migraine days / month 150 U N=100 195 U N=100 Placebo N=100 Chronic Migraine N=465 ≥ 15 headache days / month And >8 migraine days / month 150 U N=155 195 U N=155 Placebo N=155 Final Analysis of the Episodic Cohort Anticipated 2H 2023 Final Analysis of the Chronic Cohort Anticipated 2024

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Episodic Migraine Cohort Chronic Migraine Cohort First Patient Treated March 2021 April 2021 Completion of Enrollment December 2022 3Q 2023 Top line report (TLR) 2H 2023 2024 Estimated TLR for P3 BOTOX Episodic Migraine (Abbvie ; NCT05028569) January 31, 2024 Phase 2 Timelines by Cohort 37

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BOTOX PREEMPT2 1 Phase 3 in chronic migraine • Baseline migraine days were 19.8 days • Change from baseline (CFB) for Botox and placebo was 45% and 33%, respectively Phase 2 assumptions: • Projected CFB of ABP - 450 and placebo is 45% and 33%, respectively • Treatment effect between placebo and active is ~1.3 days • Standard deviation (SD) of 3.1 days • Sample size of 91 patients/arm (n=273 for all 3 arms) is needed to achieve 80% statistical power 1. https://headachejournal.onlinelibrary.wiley.com/doi/epdf/10.1111/j.1526 - 4610.2010.01678.x 38 Endpoint Expectations for Phase 2 Episodic Migraine Statistical Powering & Sample Size Assumptions Expected Baseline (days) Projected CFB ABP - 450 Projected CFB Placebo Effect Size Stnd . Dev. Evaluable Subjects/Arm TOTAL N Power 10.5 - 4.73 (45%) - 3.47 (33%) - 1.3 3.1 91 273 80%

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Conclusions and ABP - 450 Competitive Profile Migraine Indication Patient Population Low Switching Barriers Injection Paradigm Pricing Dynamics AEON will be the second botulinum toxin product in migraine prevention, the single largest toxin therapeutic indication for the market leader (45% of therapeutic toxin sales) Migraine Phase 2 program includes BOTH chronic and episodic migraine patients more than tripling the market leader's addressable population (currently approved only for chronic migraine) New market entrants have been hindered by differentiated toxin characteristics, complicating physician adoption. 900 kDA weighting and similar characteristics simplify transition to ABP - 450 U nique injection paradigm featuring fewer injections (22 injections vs. 31 injections) which has the potential to deliver a safety and tolerability benefit Therapeutic only focus provides pricing flexibility without the negative impact of heavy discounting from aesthetic indication 39

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Fireside Chat and Q&A Moderated by: Corey Davis Managing Director LifeSci Advisors 40

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Thank you