# EDGAR Filing Document

**Accession Number:** 0001442756
**File Stem:** 0001104659-23-021550
**Filing Date:** 2023-2
**Character Count:** 12873
**Document Hash:** b57305945d088e393a03c5fb65489e91
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-23-021550.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001104659-23-021550

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**EFFECTIVENESS DATE**: 20230214

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** PFM Health Sciences, LP
- **CENTRAL INDEX KEY:** 0001442756
- **IRS NUMBER:** 262000428
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-13169
- **FILM NUMBER:** 23628998

**BUSINESS ADDRESS:**
- **STREET 1:** 475 SANSOME STREET
- **STREET 2:** SUITE 1720
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94111
- **BUSINESS PHONE:** 415-281-1022

**MAIL ADDRESS:**
- **STREET 1:** 475 SANSOME STREET
- **STREET 2:** SUITE 1720
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94111

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Partner Fund Management, L.P.
- **DATE OF NAME CHANGE:** 20080812

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2022

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** PFM Health Sciences LP<br>**Address:** 475 Sansome Street<br>Suite 1720<br>San Francisco, CA 94111

**Form 13F File Number:** 028-13169

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Darin Sadow<br>**Title:** General Counsel and Chief Compliance Officer<br>**Phone:** 415-281-1000

**Signature, Place, and Date of Signing:**

/s/ Darin Sadow  San Francisco, CA  02-14-2023<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 89

**Form 13F Information Table Value Total:** $2792762221

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| ABBVIE INC | COM | 00287Y109 |  | 16161000 | 100000 | SH | Call | DFND |  | 0 | 100000 | 0 |
| ABBVIE INC | COM | 00287Y109 |  | 53225284 | 329344 | SH |  | DFND |  | 0 | 329344 | 0 |
| ADAPTIMMUNE THERAPEUTICS PLC | SPONDS ADR | 00653A107 |  | 7071525 | 4843510 | SH |  | DFND |  | 0 | 4843510 | 0 |
| AGILENT TECHNOLOGIES INC | COM | 00846U101 |  | 27461374 | 183504 | SH |  | DFND |  | 0 | 183504 | 0 |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 |  | 16465602 | 318422 | SH |  | DFND |  | 0 | 318422 | 0 |
| ARCELLX INC | COMMON STOCK | 03940C100 |  | 19099635 | 616515 | SH |  | DFND |  | 0 | 616515 | 0 |
| ARCUS BIOSCIENCES INC | COM | 03969F109 |  | 55903975 | 2703287 | SH |  | DFND |  | 0 | 2703287 | 0 |
| ARGENX SE | SPONSORED ADR | 04016X101 |  | 39675624 | 104732 | SH |  | DFND |  | 0 | 104732 | 0 |
| ASTRAZENECA PLC | SPONSORED ADR | 046353108 |  | 39107040 | 576800 | SH |  | DFND |  | 0 | 576800 | 0 |
| AVANTOR INC | COM | 05352A100 |  | 33904537 | 1607612 | SH |  | DFND |  | 0 | 1607612 | 0 |
| AXSOME THERAPEUTICS INC | COM | 05464T104 |  | 23061870 | 299000 | SH | Call | DFND |  | 0 | 299000 | 0 |
| AXSOME THERAPEUTICS INC | COM | 05464T104 |  | 84290055 | 1092831 | SH |  | DFND |  | 0 | 1092831 | 0 |
| BELLUS HEALTH INC NEW | COM NEW | 07987C204 |  | 524962 | 63864 | SH |  | DFND |  | 0 | 63864 | 0 |
| BIOCRYST PHARMACEUTICALS INC | COM | 09058V103 |  | 24824478 | 2162411 | SH |  | DFND |  | 0 | 2162411 | 0 |
| BIOGEN INC | COM | 09062X103 |  | 43105090 | 155659 | SH |  | DFND |  | 0 | 155659 | 0 |
| BIOHAVEN LTD | COM | G1110E107 |  | 152513 | 10988 | SH |  | DFND |  | 0 | 10988 | 0 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 |  | 25148070 | 243000 | SH | Call | DFND |  | 0 | 243000 | 0 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 |  | 32123399 | 310401 | SH |  | DFND |  | 0 | 310401 | 0 |
| BIOMARIN PHARMACEUTICAL INC | NOTE  0.599% 8/0 | 09061GAH4 |  | 38201058 | 35910000 | PRN |  | DFND |  | 0 | 35910000 | 0 |
| BLUEBIRD BIO INC | COM | 09609G100 |  | 1694480 | 244867 | SH |  | DFND |  | 0 | 244867 | 0 |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 |  | 5711334 | 130366 | SH |  | DFND |  | 0 | 130366 | 0 |
| CARDINAL HEALTH INC | COM | 14149Y108 |  | 49180119 | 639783 | SH |  | DFND |  | 0 | 639783 | 0 |
| CARIBOU BIOSCIENCES INC | COM | 142038108 |  | 28007437 | 4459783 | SH |  | DFND |  | 0 | 4459783 | 0 |
| CELCUITY INC | COM | 15102K100 |  | 9976675 | 712111 | SH |  | DFND |  | 0 | 712111 | 0 |
| CENTENE CORP DEL | COM | 15135B101 |  | 91234485 | 1112480 | SH |  | DFND |  | 0 | 1112480 | 0 |
| CHARLES RIV LABS INTL INC | COM | 159864107 |  | 15867478 | 72820 | SH |  | DFND |  | 0 | 72820 | 0 |
| CIGNA CORP NEW | COM | 125523100 |  | 46818342 | 141300 | SH |  | DFND |  | 0 | 141300 | 0 |
| COMPASS PATHWAYS PLC | SPONSORED ADS | 20451W101 |  | 4092289 | 509625 | SH |  | DFND |  | 0 | 509625 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 109947152 | 2399545 | SH |  | DFND |  | 0 | 2399545 | 0 |
| DANAHER CORPORATION | COM | 235851102 |  | 46631640 | 175690 | SH |  | DFND |  | 0 | 175690 | 0 |
| DEXCOM INC | COM | 252131107 |  | 15340057 | 135465 | SH |  | DFND |  | 0 | 135465 | 0 |
| DYNAVAX TECHNOLOGIES CORP | COM NEW | 268158201 |  | 40489137 | 3805370 | SH |  | DFND |  | 0 | 3805370 | 0 |
| EDITAS MEDICINE INC | COM | 28106W103 |  | 13009913 | 1466732 | SH |  | DFND |  | 0 | 1466732 | 0 |
| EDWARDS LIFESCIENCES CORP | COM | 28176E108 |  | 39545538 | 530030 | SH |  | DFND |  | 0 | 530030 | 0 |
| ELEVANCE HEALTH INC | COM | 036752103 |  | 34427982 | 67115 | SH |  | DFND |  | 0 | 67115 | 0 |
| ERASCA INC | COM | 29479A108 |  | 20677053 | 4797460 | SH |  | DFND |  | 0 | 4797460 | 0 |
| ESSA PHARMA INC | COM NEW | 29668H708 |  | 9687717 | 3844332 | SH |  | DFND |  | 0 | 3844332 | 0 |
| GENERATION BIO CO | COM | 37148K100 |  | 11409545 | 2903192 | SH |  | DFND |  | 0 | 2903192 | 0 |
| HCA HEALTHCARE INC | COM | 40412C101 |  | 22063122 | 91945 | SH |  | DFND |  | 0 | 91945 | 0 |
| HORIZON THERAPEUTICS PUB L | SHS | G46188101 |  | 124251392 | 1091840 | SH |  | DFND |  | 0 | 1091840 | 0 |
| HUMANA INC | COM | 444859102 |  | 85057345 | 166066 | SH |  | DFND |  | 0 | 166066 | 0 |
| ICON PLC | SHS | G4705A100 |  | 15875081 | 81725 | SH |  | DFND |  | 0 | 81725 | 0 |
| INTUITIVE SURGICAL INC | COM NEW | 46120E602 |  | 30369308 | 114450 | SH |  | DFND |  | 0 | 114450 | 0 |
| IO BIOTECH INC | COM | 449778109 |  | 1167572 | 507640 | SH |  | DFND |  | 0 | 507640 | 0 |
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 |  | 85223 | 13337 | SH |  | DFND |  | 0 | 13337 | 0 |
| IQVIA HLDGS INC | COM | 46266C105 |  | 46936406 | 229081 | SH |  | DFND |  | 0 | 229081 | 0 |
| IRHYTHM TECHNOLOGIES INC | COM | 450056106 |  | 46246846 | 493721 | SH |  | DFND |  | 0 | 493721 | 0 |
| ITEOS THERAPEUTICS INC | COM | 46565G104 |  | 1385107 | 70922 | SH |  | DFND |  | 0 | 70922 | 0 |
| IVERIC BIO INC | COM | 46583P102 |  | 19644895 | 917557 | SH |  | DFND |  | 0 | 917557 | 0 |
| JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 |  | 20471335 | 128500 | SH | Put | DFND |  | 0 | 128500 | 0 |
| JOHNSON  JOHNSON | COM | 478160104 |  | 24332831 | 137746 | SH |  | DFND |  | 0 | 137746 | 0 |
| JOHNSON  JOHNSON | COM | 478160104 |  | 79492500 | 450000 | SH | Put | DFND |  | 0 | 450000 | 0 |
| JOUNCE THERAPEUTICS INC | COM | 481116101 |  | 383978 | 345926 | SH |  | DFND |  | 0 | 345926 | 0 |
| KARUNA THERAPEUTICS INC | COM | 48576A100 |  | 25602575 | 130293 | SH |  | DFND |  | 0 | 130293 | 0 |
| KEROS THERAPEUTICS INC | COM | 492327101 |  | 768272 | 15999 | SH |  | DFND |  | 0 | 15999 | 0 |
| LABORATORY CORP AMER HLDGS | COM NEW | 50540R409 |  | 52983000 | 225000 | SH | Call | DFND |  | 0 | 225000 | 0 |
| LABORATORY CORP AMER HLDGS | COM NEW | 50540R409 |  | 3193344 | 13561 | SH |  | DFND |  | 0 | 13561 | 0 |
| LILLY ELI  CO | COM | 532457108 |  | 109255555 | 298643 | SH |  | DFND |  | 0 | 298643 | 0 |
| MCKESSON CORP | COM | 58155Q103 |  | 39691822 | 105811 | SH |  | DFND |  | 0 | 105811 | 0 |
| MERCK  CO INC | COM | 58933Y105 |  | 96692925 | 871500 | SH | Call | DFND |  | 0 | 871500 | 0 |
| MERCK  CO INC | COM | 58933Y105 |  | 40788992 | 367634 | SH |  | DFND |  | 0 | 367634 | 0 |
| MOLINA HEALTHCARE INC | COM | 60855R100 |  | 47478701 | 143779 | SH |  | DFND |  | 0 | 143779 | 0 |
| NEVRO CORP | NOTE  2.750% 4/0 | 64157FAC7 |  | 16056250 | 17500000 | PRN |  | DFND |  | 0 | 17500000 | 0 |
| OAK STR HEALTH INC | COM | 67181A107 |  | 12158291 | 565239 | SH |  | DFND |  | 0 | 565239 | 0 |
| OAK STR HEALTH INC | NOTE         3/1 | 67181AAB3 |  | 48002100 | 63000000 | PRN |  | DFND |  | 0 | 63000000 | 0 |
| PENUMBRA INC | COM | 70975L107 |  | 52834250 | 237500 | SH | Call | DFND |  | 0 | 237500 | 0 |
| PENUMBRA INC | COM | 70975L107 |  | 80092274 | 360030 | SH |  | DFND |  | 0 | 360030 | 0 |
| PMV PHARMACEUTICALS INC | COM | 69353Y103 |  | 2903329 | 333716 | SH |  | DFND |  | 0 | 333716 | 0 |
| POINT BIOPHARMA GLOBAL INC | COM | 730541109 |  | 33780417 | 4633802 | SH |  | DFND |  | 0 | 4633802 | 0 |
| PRAXIS PRECISION MEDICINES I | COM | 74006W108 |  | 6610371 | 2777467 | SH |  | DFND |  | 0 | 2777467 | 0 |
| PROCEPT BIOROBOTICS CORP | COM | 74276L105 |  | 21498030 | 517526 | SH |  | DFND |  | 0 | 517526 | 0 |
| PROTHENA CORP PLC | SHS | G72800108 |  | 9176075 | 152300 | SH | Call | DFND |  | 0 | 152300 | 0 |
| PROTHENA CORP PLC | SHS | G72800108 |  | 52746706 | 875464 | SH |  | DFND |  | 0 | 875464 | 0 |
| PULMONX CORP | COM | 745848101 |  | 12272141 | 1455770 | SH |  | DFND |  | 0 | 1455770 | 0 |
| SANA BIOTECHNOLOGY INC | COM | 799566104 |  | 247965 | 62776 | SH |  | DFND |  | 0 | 62776 | 0 |
| SEAGEN INC | COM | 81181C104 |  | 24723268 | 192384 | SH |  | DFND |  | 0 | 192384 | 0 |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 |  | 46182435 | 1814634 | SH |  | DFND |  | 0 | 1814634 | 0 |
| TENET HEALTHCARE CORP | COM NEW | 88033G407 |  | 11021661 | 225900 | SH | Call | DFND |  | 0 | 225900 | 0 |
| TENET HEALTHCARE CORP | COM NEW | 88033G407 |  | 12418275 | 254525 | SH |  | DFND |  | 0 | 254525 | 0 |
| THERMO FISHER SCIENTIFIC INC | COM | 883556102 |  | 34221529 | 62143 | SH |  | DFND |  | 0 | 62143 | 0 |
| UNIQURE NV | SHS | N90064101 |  | 52193458 | 2302314 | SH |  | DFND |  | 0 | 2302314 | 0 |
| UNITEDHEALTH GROUP INC | COM | 91324P102 |  | 36900528 | 69600 | SH | Call | DFND |  | 0 | 69600 | 0 |
| UNITEDHEALTH GROUP INC | COM | 91324P102 |  | 61536402 | 116067 | SH |  | DFND |  | 0 | 116067 | 0 |
| UNIVERSAL HLTH SVCS INC | CL B | 913903100 |  | 17529675 | 124421 | SH |  | DFND |  | 0 | 124421 | 0 |
| VECTIVBIO HLDG AG | ORD SHS | H9060V101 |  | 221313 | 25541 | SH |  | DFND |  | 0 | 25541 | 0 |
| VERVE THERAPEUTICS INC | COM | 92539P101 |  | 4204794 | 217302 | SH |  | DFND |  | 0 | 217302 | 0 |
| WATERS CORP | COM | 941848103 |  | 32416290 | 94624 | SH |  | DFND |  | 0 | 94624 | 0 |
| WEREWOLF THERAPEUTICS INC | COM | 95075A107 |  | 2651251 | 1293293 | SH |  | DFND |  | 0 | 1293293 | 0 |
| XENON PHARMACEUTICALS INC | COM | 98420N105 |  | 689552 | 17488 | SH |  | DFND |  | 0 | 17488 | 0 |

---