# EDGAR Filing Document

**Accession Number:** 0001683553
**File Stem:** 0001193125-25-293646
**Filing Date:** 2025-11
**Character Count:** 2637
**Document Hash:** 566c2699ddbd03c779511e8c64f2ca25
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-25-293646.hdr.sgml**: 20260407

**ACCESSION NUMBER**: 0001193125-25-293646

**CONFORMED SUBMISSION TYPE**: CORRESP

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20251124

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** SPRUCE BIOSCIENCES, INC.
- **CENTRAL INDEX KEY:** 0001683553
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 812154263
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** CORRESP

**BUSINESS ADDRESS:**
- **STREET 1:** 611 GATEWAY BOULEVARD, SUITE 740
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080
- **BUSINESS PHONE:** (415) 655-4168

**MAIL ADDRESS:**
- **STREET 1:** 611 GATEWAY BOULEVARD, SUITE 740
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080

**SPRUCE BIOSCIENCES, INC.** 

611 Gateway Boulevard, Suite 740

South San Francisco, California 94080

November 24, 2025

***VIA EDGAR***

Securities and Exchange Commission

Office of Finance

Division of Corporation Finance

100 F. Street N.E.

Washington, D.C. 20549-3010

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| | |
|:---|:---|
| **RE:** | **Spruce Biosciences, Inc.**  |

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**Registration Statement on Form S-3 (File No. 333-291152)** 

**Request for Acceleration of Effective Date** 

Ladies and Gentlemen:

Spruce Biosciences, Inc. (the "**Registrant**") hereby requests that the U.S. Securities and Exchange Commission (the "**Commission**") take appropriate action to cause the above-referenced Registration Statement on Form S-3 (File No. 333-291152) (the "**Registration Statement**") to become effective on Wednesday, November 26, 2025, at 4:30 p.m., Eastern Time, or as soon thereafter as is practicable or at such later time as the Registrant may orally request via telephone call to the staff of the Commission. The Registrant hereby authorizes each of Katherine Denby and Alexander Gefter of Cooley LLP, counsel to the Registrant, to make such request on its behalf.

Once the Registration Statement has been declared effective, please orally confirm that event with Katherine Denby of Cooley LLP, counsel to the Registrant, at (202) 776-2070, or in her absence, Alexander Gefter at (310) 883-6438.

*[Remainder of page intentionally left blank]* 

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| | |
|:---|:---|
| Very truly yours, | Very truly yours, |
| **SPRUCE BIOSCIENCES, INC.** | **SPRUCE BIOSCIENCES, INC.** |
| By: | /s/ Samir Gharib |
| Name: | Samir Gharib |
| Title: | President and Chief Financial Officer |

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cc: Katherine Denby, Cooley LLP

Alexander Gefter, Cooley LLP