# EDGAR Filing Document

**Accession Number:** 0000908259
**File Stem:** 0001493152-25-028826
**Filing Date:** 2025-12
**Character Count:** 1900
**Document Hash:** 7a77530b1828e27c0dff0e0347bfbe56
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001493152-25-028826.hdr.sgml**: 20260616

**ACCESSION NUMBER**: 0001493152-25-028826

**CONFORMED SUBMISSION TYPE**: CORRESP

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20251222

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Oncotelic Therapeutics, Inc.
- **CENTRAL INDEX KEY:** 0000908259
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 133679168
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** CORRESP

**BUSINESS ADDRESS:**
- **STREET 1:** 29397 AGOURA RD.
- **STREET 2:** #107
- **CITY:** AGUORA HILLS
- **STATE:** CA
- **ZIP:** 91301
- **BUSINESS PHONE:** 650-635-7000

**MAIL ADDRESS:**
- **STREET 1:** 29397 AGOURA RD.
- **STREET 2:** #107
- **CITY:** AGUORA HILLS
- **STATE:** CA
- **ZIP:** 91301

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** MATEON THERAPEUTICS INC
- **DATE OF NAME CHANGE:** 20160613

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** OXIGENE INC
- **DATE OF NAME CHANGE:** 19930628

December 22, 2025

VIA EDGAR

Securities and Exchange Commission,

100 F Street N.E.

Washington, DC 20549

Attn: Doris Gana

Re: <u>Oncotelic Therapeutics, Inc.</u> <br> <u>Registration Statement on Form S-1</u> <br> <u>File No. 333-291724</u>

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, Oncotelic Therapeutics, Inc, a Delaware corporation hereby respectfully requests that the effectiveness of the above-referenced Registration Statement on Form S-1 be accelerated to 4:00 p.m. Eastern Time on Tuesday, December 23, 2025, or as soon thereafter as practicable.

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| | |
|:---|:---|
| Sincerely, | Sincerely, |
| Oncotelic Therapeutics, Inc. | Oncotelic Therapeutics, Inc. |
| By | */s/ Vuong Trieu* |
|  | Vuong Trieu |
|  | Chief Executive Officer |

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