# EDGAR Filing Document

**Accession Number:** 0002026172
**File Stem:** 0001892688-26-000076
**Filing Date:** 2026-5
**Character Count:** 18398
**Document Hash:** 37fadd4bd8880832407024df6495ad2e
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001892688-26-000076.hdr.sgml**: 20260515

**ACCESSION NUMBER**: 0001892688-26-000076

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20260331

**FILED AS OF DATE**: 20260515

**DATE AS OF CHANGE**: 20260515

**EFFECTIVENESS DATE**: 20260515

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** DIADEMA PARTNERS LP
- **CENTRAL INDEX KEY:** 0002026172

**ORGANIZATION NAME:**
- **EIN:** 991928849
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-25172
- **FILM NUMBER:** 26983625

**BUSINESS ADDRESS:**
- **STREET 1:** 2140 HEADQUARTERS PLAZA
- **STREET 2:** EAST TOWER, 2ND FLOOR
- **CITY:** MORRISTOWN
- **STATE:** NJ
- **ZIP:** 07960
- **BUSINESS PHONE:** 917-513-8539

**MAIL ADDRESS:**
- **STREET 1:** 2140 HEADQUARTERS PLAZA
- **STREET 2:** EAST TOWER, 2ND FLOOR
- **CITY:** MORRISTOWN
- **STATE:** NJ
- **ZIP:** 07960

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 03-31-2026

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** DIADEMA PARTNERS LP<br>**Address:** 2140 HEADQUARTERS PLAZA<br>EAST TOWER 2ND FLOOR<br>MORRISTOWN, NJ 07960

**Form 13F File Number:** 028-25172

**CRD Number (if applicable):** 000331527

**SEC File Number (if applicable):** 801-130477

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** ZACHARY CANONICO<br>**Title:** CHIEF COMPLIANCE OFFICER AND CHIEF OPERATING OFFICER<br>**Phone:** 646-979-8432

**Signature, Place, and Date of Signing:**

ZACHARY CANONICO  MORRISTOWN, NJ  05-15-2026<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 144

**Form 13F Information Table Value Total:** $587736973

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| ABBVIE INC | COM | 00287Y109 |  | 5232374 | 24058 | SH |  | SOLE |  | 24058 | 0 | 0 |
| ABIVAX SA | SPONSORED ADS | 00370M103 |  | 8217262 | 75944 | SH |  | SOLE |  | 75944 | 0 | 0 |
| ABIVAX SA | SPONSORED ADS | 00370M103 |  | 11135000 | 100000 | SH | Put | SOLE |  | 100000 | 0 | 0 |
| ABIVAX SA | SPONSORED ADS | 00370M103 |  | 11135000 | 100000 | SH | Call | SOLE |  | 100000 | 0 | 0 |
| ALKERMES PLC | SHS | G01767105 |  | 1768000 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| ALUMIS INC | COM | 022307102 |  | 687336 | 31200 | SH | Put | SOLE |  | 31200 | 0 | 0 |
| ALUMIS INC | COM | 022307102 |  | 2203000 | 100000 | SH | Call | SOLE |  | 100000 | 0 | 0 |
| ANAVEX LIFE SCIENCES CORP | COM NEW | 032797300 |  | 1466232 | 477600 | SH | Call | SOLE |  | 477600 | 0 | 0 |
| ANNEXON INC | COM | 03589W102 |  | 1956728 | 353200 | SH | Call | SOLE |  | 353200 | 0 | 0 |
| ANNEXON INC | COM | 03589W102 |  | 736355 | 132916 | SH |  | SOLE |  | 132916 | 0 | 0 |
| APOGEE THERAPEUTICS INC | COM | 03770N101 |  | 18727825 | 222500 | SH | Call | SOLE |  | 222500 | 0 | 0 |
| ARCUS BIOSCIENCES INC | COM | 03969F109 |  | 5143867 | 238142 | SH |  | SOLE |  | 238142 | 0 | 0 |
| ATRIUM THERAPEUTICS INC | COM | 04965N104 |  | 33585 | 2512 | SH |  | SOLE |  | 2512 | 0 | 0 |
| ATYR PHARMA INC | COM NEW | 002120202 |  | 9516 | 12200 | SH | Call | SOLE |  | 12200 | 0 | 0 |
| ATYR PHARMA INC | COM NEW | 002120202 |  | 9750 | 12500 | SH | Put | SOLE |  | 12500 | 0 | 0 |
| AYTU BIOPHARMA INC | COM | 054754858 |  | 963900 | 353077 | SH |  | SOLE |  | 353077 | 0 | 0 |
| BICYCLE THERAPEUTICS PLC | SPONSORED ADS | 088786108 |  | 2210607 | 476424 | SH |  | SOLE |  | 476424 | 0 | 0 |
| BIOAGE LABS INC | COM | 09077V100 |  | 1049400 | 60000 | SH |  | SOLE |  | 60000 | 0 | 0 |
| BIOHAVEN LTD | COM | G1110E107 |  | 2681820 | 317000 | SH | Call | SOLE |  | 317000 | 0 | 0 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 |  | 8373456 | 148229 | SH |  | SOLE |  | 148229 | 0 | 0 |
| BRIDGEBIO PHARMA INC | COM | 10806X102 |  | 6335195 | 85311 | SH |  | SOLE |  | 85311 | 0 | 0 |
| BRIDGEBIO PHARMA INC | NOTE 1.750% 3/0 | 10806XAJ1 |  | 18565000 | 250000 | SH |  | SOLE |  | 250000 | 0 | 0 |
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 |  | 10010720 | 329300 | SH | Call | SOLE |  | 329300 | 0 | 0 |
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 |  | 18951360 | 623400 | SH | Put | SOLE |  | 623400 | 0 | 0 |
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 |  | 2397070 | 78851 | SH |  | SOLE |  | 78851 | 0 | 0 |
| CELCUITY INC | COM | 15102K100 |  | 2020278 | 17700 | SH | Call | SOLE |  | 17700 | 0 | 0 |
| CELCUITY INC | COM | 15102K100 |  | 606540 | 5314 | SH |  | SOLE |  | 5314 | 0 | 0 |
| CLIMB BIO INC | COM | 28658R106 |  | 1959963 | 286126 | SH |  | SOLE |  | 286126 | 0 | 0 |
| COGENT BIOSCIENCES INC | COM | 19240Q201 |  | 12423186 | 322764 | SH |  | SOLE |  | 322764 | 0 | 0 |
| COMPASS PATHWAYS PLC | SPONSORED ADS | 20451W101 |  | 176324 | 31885 | SH |  | SOLE |  | 31885 | 0 | 0 |
| CONNECT BIOPHARMA HLDGS LTD | SHS | G23549101 |  | 525808 | 200690 | SH |  | SOLE |  | 200690 | 0 | 0 |
| CORBUS PHARMACEUTICALS HLDGS | COM NEW | 21833P301 |  | 1082667 | 115300 | SH | Call | SOLE |  | 115300 | 0 | 0 |
| CORBUS PHARMACEUTICALS HLDGS | COM NEW | 21833P301 |  | 4131196 | 439957 | SH |  | SOLE |  | 439957 | 0 | 0 |
| CORCEPT THERAPEUTICS INC | COM | 218352102 |  | 403100 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| CORCEPT THERAPEUTICS INC | COM | 218352102 |  | 6389135 | 158500 | SH | Call | SOLE |  | 158500 | 0 | 0 |
| CORMEDIX INC | COM | 21900C308 |  | 1137325 | 167500 | SH | Put | SOLE |  | 167500 | 0 | 0 |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 |  | 3581585 | 244811 | SH |  | SOLE |  | 244811 | 0 | 0 |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 |  | 1555169 | 106300 | SH | Call | SOLE |  | 106300 | 0 | 0 |
| CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 |  | 5056691 | 106300 | SH | Call | SOLE |  | 106300 | 0 | 0 |
| CUE BIOPHARMA INC | COM | 22978P106 |  | 30346 | 131997 | SH |  | SOLE |  | 131997 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 3295500 | 50000 | SH | Call | SOLE |  | 50000 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 13182000 | 200000 | SH | Put | SOLE |  | 200000 | 0 | 0 |
| CYTOMX THERAPEUTICS INC. | COM | 23284F105 |  | 1485200 | 316000 | SH | Call | SOLE |  | 316000 | 0 | 0 |
| DIANTHUS THERAPEUTICS INC | COM | 252828108 |  | 839200 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 |  | 6693750 | 212500 | SH | Call | SOLE |  | 212500 | 0 | 0 |
| ELI LILLY  CO | COM | 532457108 |  | 5518620 | 6000 | SH |  | SOLE |  | 6000 | 0 | 0 |
| ENANTA PHARMACEUTICALS INC | COM | 29251M106 |  | 820344 | 64952 | SH |  | SOLE |  | 64952 | 0 | 0 |
| ENLIVEN THERAPEUTICS INC | COM | 29337E102 |  | 9604 | 245 | SH |  | SOLE |  | 245 | 0 | 0 |
| ENTERA BIO LTD | SHS | M40527109 |  | 25819 | 23260 | SH |  | SOLE |  | 23260 | 0 | 0 |
| EQUILLIUM INC | COM | 29446K106 |  | 867688 | 433844 | SH |  | SOLE |  | 433844 | 0 | 0 |
| EUPRAXIA PHARMACEUTICALS INC | COM | 29842P105 |  | 289600 | 40000 | SH |  | SOLE |  | 40000 | 0 | 0 |
| EVOLUS INC | COM | 30052C107 |  | 514572 | 125200 | SH | Call | SOLE |  | 125200 | 0 | 0 |
| EYEPOINT INC | COM NEW | 30233G209 |  | 1370207 | 106300 | SH | Call | SOLE |  | 106300 | 0 | 0 |
| EYEPOINT INC | COM NEW | 30233G209 |  | 2301445 | 178545 | SH |  | SOLE |  | 178545 | 0 | 0 |
| FOGHORN THERAPEUTICS INC | COM | 344174107 |  | 382132 | 79944 | SH |  | SOLE |  | 79944 | 0 | 0 |
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 |  | 377314 | 26836 | SH |  | SOLE |  | 26836 | 0 | 0 |
| HARMONY BIOSCIENCES HLDGS IN | COM | 413197104 |  | 2601121 | 92864 | SH |  | SOLE |  | 92864 | 0 | 0 |
| IMMUNITYBIO INC | COM | 45256X103 |  | 815321 | 106300 | SH | Put | SOLE |  | 106300 | 0 | 0 |
| IMMUNOCORE HLDGS PLC | ADS | 45258D105 |  | 5824648 | 193189 | SH |  | SOLE |  | 193189 | 0 | 0 |
| INCYTE CORP | COM | 45337C102 |  | 9920248 | 105400 | SH | Put | SOLE |  | 105400 | 0 | 0 |
| INCYTE CORP | COM | 45337C102 |  | 7344089 | 78029 | SH |  | SOLE |  | 78029 | 0 | 0 |
| INDIVIOR PHARMACEUTICALS INC | COM | 45579U109 |  | 2175540 | 71376 | SH |  | SOLE |  | 71376 | 0 | 0 |
| INOVIO PHARMACEUTICALS INC | COM SHS | 45773H409 |  | 130848 | 75200 | SH | Call | SOLE |  | 75200 | 0 | 0 |
| INOVIO PHARMACEUTICALS INC | COM SHS | 45773H409 |  | 979037 | 562665 | SH |  | SOLE |  | 562665 | 0 | 0 |
| INTELLIA THERAPEUTICS INC | COM | 45826J105 |  | 2564000 | 200000 | SH | Call | SOLE |  | 200000 | 0 | 0 |
| INVENTIVA SA | ADS | 46124U107 |  | 1935023 | 352399 | SH |  | SOLE |  | 352399 | 0 | 0 |
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 |  | 10179 | 2900 | SH | Put | SOLE |  | 2900 | 0 | 0 |
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 |  | 1053000 | 300000 | SH | Call | SOLE |  | 300000 | 0 | 0 |
| JADE BIOSCIENCES INC | COM NEW | 008064206 |  | 2930 | 1046 | SH | Put | SOLE |  | 1046 | 0 | 0 |
| JANUX THERAPEUTICS INC | COM | 47103J105 |  | 439240 | 31600 | SH | Call | SOLE |  | 31600 | 0 | 0 |
| JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 |  | 10351433 | 54755 | SH |  | SOLE |  | 54755 | 0 | 0 |
| JOHNSON  JOHNSON | COM | 478160104 |  | 13143783 | 53771 | SH |  | SOLE |  | 53771 | 0 | 0 |
| KARYOPHARM THERAPEUTICS INC | COM NEW | 48576U205 |  | 1344041 | 241300 | SH | Call | SOLE |  | 241300 | 0 | 0 |
| KODIAK SCIENCES INC | COM | 50015M109 |  | 9411828 | 246900 | SH | Put | SOLE |  | 246900 | 0 | 0 |
| KODIAK SCIENCES INC | COM | 50015M109 |  | 7355711 | 192962 | SH |  | SOLE |  | 192962 | 0 | 0 |
| KODIAK SCIENCES INC | COM | 50015M109 |  | 7624 | 200 | SH | Call | SOLE |  | 200 | 0 | 0 |
| LARIMAR THERAPEUTICS INC | COM | 517125100 |  | 749867 | 166637 | SH |  | SOLE |  | 166637 | 0 | 0 |
| LIPOCINE INC NEW | COM NEW | 53630X203 |  | 399500 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| LIQUIDIA CORPORATION | COM NEW | 53635D202 |  | 24987654 | 662100 | SH | Call | SOLE |  | 662100 | 0 | 0 |
| LIQUIDIA CORPORATION | COM NEW | 53635D202 |  | 1887000 | 50000 | SH | Put | SOLE |  | 50000 | 0 | 0 |
| LYELL IMMUNOPHARMA INC | COM NEW | 55083R203 |  | 82246 | 4100 | SH | Put | SOLE |  | 4100 | 0 | 0 |
| MACROGENICS INC | COM | 556099109 |  | 1734000 | 600000 | SH |  | SOLE |  | 600000 | 0 | 0 |
| MANNKIND CORP | COM NEW | 56400P706 |  | 457177 | 186603 | SH |  | SOLE |  | 186603 | 0 | 0 |
| MAZE THERAPEUTICS INC | COM | 578784100 |  | 447750 | 15000 | SH |  | SOLE |  | 15000 | 0 | 0 |
| MERCK  CO INC | COM | 58933Y105 |  | 12029000 | 100000 | SH | Put | SOLE |  | 100000 | 0 | 0 |
| MINERALYS THERAPEUTICS INC | COM | 603170101 |  | 713740 | 26347 | SH |  | SOLE |  | 26347 | 0 | 0 |
| MODERNA INC | COM | 60770K107 |  | 8097520 | 159400 | SH | Put | SOLE |  | 159400 | 0 | 0 |
| MONOPAR THERAPEUTICS INC | COM NEW | 61023L207 |  | 89308 | 1630 | SH |  | SOLE |  | 1630 | 0 | 0 |
| MONTE ROSA THERAPEUTICS INC | COM | 61225M102 |  | 3081200 | 187307 | SH |  | SOLE |  | 187307 | 0 | 0 |
| NOVO-NORDISK A S | ADR | 670100205 |  | 520736 | 14577 | SH |  | SOLE |  | 14577 | 0 | 0 |
| NOVO-NORDISK A S | ADR | 670100205 |  | 2054325 | 55900 | SH | Put | SOLE |  | 55900 | 0 | 0 |
| OCUGEN INC | COM | 67577C105 |  | 362000 | 200000 | SH |  | SOLE |  | 200000 | 0 | 0 |
| OCUGEN INC | COM | 67577C105 |  | 543000 | 300000 | SH | Call | SOLE |  | 300000 | 0 | 0 |
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 |  | 1252440 | 84000 | SH | Call | SOLE |  | 84000 | 0 | 0 |
| PASSAGE BIO INC | COM NEW | 702712209 |  | 153311 | 19530 | SH |  | SOLE |  | 19530 | 0 | 0 |
| PELTHOS THERAPEUTICS INC | COM SHS | 171126204 |  | 520481 | 24773 | SH |  | SOLE |  | 24773 | 0 | 0 |
| PEPGEN INC | COM | 713317105 |  | 267137 | 150925 | SH |  | SOLE |  | 150925 | 0 | 0 |
| PHARVARIS N V | COM | N69605108 |  | 828318 | 29321 | SH |  | SOLE |  | 29321 | 0 | 0 |
| PHATHOM PHARMACEUTICALS INC | COM | 71722W107 |  | 607162 | 54650 | SH |  | SOLE |  | 54650 | 0 | 0 |
| PRECIGEN INC | COM | 74017N105 |  | 213984 | 55293 | SH |  | SOLE |  | 55293 | 0 | 0 |
| PROQR THRAPEUTICS N V | SHS EURO | N71542109 |  | 291734 | 180083 | SH |  | SOLE |  | 180083 | 0 | 0 |
| PURETECH HEALTH PLC | ADS | 746237106 |  | 11327 | 7924 | SH |  | SOLE |  | 7924 | 0 | 0 |
| RELMADA THERAPEUTICS INC | COM | 75955J402 |  | 1397860 | 200842 | SH |  | SOLE |  | 200842 | 0 | 0 |
| REPLIMUNE GROUP INC | COM | 76029N106 |  | 770049 | 100660 | SH |  | SOLE |  | 100660 | 0 | 0 |
| REPLIMUNE GROUP INC | COM | 76029N106 |  | 3518235 | 459900 | SH | Put | SOLE |  | 459900 | 0 | 0 |
| REPLIMUNE GROUP INC | COM | 76029N106 |  | 1572075 | 205500 | SH | Call | SOLE |  | 205500 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 7864802 | 80872 | SH |  | SOLE |  | 80872 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 12204875 | 125500 | SH | Put | SOLE |  | 125500 | 0 | 0 |
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 |  | 109473 | 30579 | SH |  | SOLE |  | 30579 | 0 | 0 |
| ROIVANT SCIENCES LTD | SHS | G76279101 |  | 9301660 | 335800 | SH | Put | SOLE |  | 335800 | 0 | 0 |
| SELLAS LIFE SCIENCES GROUP I | COM NEW | 81642T209 |  | 1269000 | 300000 | SH | Call | SOLE |  | 300000 | 0 | 0 |
| SEPTERNA INC | COM | 81734D104 |  | 4854 | 202 | SH |  | SOLE |  | 202 | 0 | 0 |
| SHATTUCK LABS INC | COM | 82024L103 |  | 1888260 | 293664 | SH |  | SOLE |  | 293664 | 0 | 0 |
| SPRUCE BIOSCIENCES INC | COM NEW | 85209E208 |  | 653500 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 |  | 3481679 | 72234 | SH |  | SOLE |  | 72234 | 0 | 0 |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 |  | 6145500 | 127500 | SH | Put | SOLE |  | 127500 | 0 | 0 |
| TALPHERA INC | COM NEW | 00444T209 |  | 114696 | 153563 | SH |  | SOLE |  | 153563 | 0 | 0 |
| TARSUS PHARMACEUTICALS INC | COM | 87650L103 |  | 1819831 | 25942 | SH |  | SOLE |  | 25942 | 0 | 0 |
| TENAX THERAPEUTICS INC | COM NEW | 88032L605 |  | 2874011 | 179738 | SH |  | SOLE |  | 179738 | 0 | 0 |
| TERNS PHARMACEUTICALS INC | COM | 880881107 |  | 9581965 | 181752 | SH |  | SOLE |  | 181752 | 0 | 0 |
| TG THERAPEUTICS INC | COM | 88322Q108 |  | 6874148 | 206928 | SH |  | SOLE |  | 206928 | 0 | 0 |
| TREVI THERAPEUTICS INC | COM | 89532M101 |  | 258440 | 21663 | SH |  | SOLE |  | 21663 | 0 | 0 |
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 |  | 736267 | 35144 | SH |  | SOLE |  | 35144 | 0 | 0 |
| UNICYCIVE THERAPEUTICS INC | COM NEW | 90466Y202 |  | 698026 | 106083 | SH |  | SOLE |  | 106083 | 0 | 0 |
| UNIQURE NV | SHS | N90064101 |  | 4087500 | 250000 | SH | Call | SOLE |  | 250000 | 0 | 0 |
| UNIQURE NV | SHS | N90064101 |  | 4888650 | 299000 | SH | Put | SOLE |  | 299000 | 0 | 0 |
| UNIQURE NV | SHS | N90064101 |  | 510120 | 31200 | SH |  | SOLE |  | 31200 | 0 | 0 |
| UNITED THERAPEUTICS CORP DEL | COM | 91307C102 |  | 11859600 | 20000 | SH | Put | SOLE |  | 20000 | 0 | 0 |
| UNITED THERAPEUTICS CORP DEL | COM | 91307C102 |  | 16190133 | 27303 | SH |  | SOLE |  | 27303 | 0 | 0 |
| UNITED THERAPEUTICS CORP DEL | COM | 91307C102 |  | 23837796 | 40200 | SH | Call | SOLE |  | 40200 | 0 | 0 |
| UPSTREAM BIO INC | COM | 91678A107 |  | 194481 | 21609 | SH |  | SOLE |  | 21609 | 0 | 0 |
| UROGEN PHARMA LTD | COM | M96088105 |  | 416327 | 23155 | SH |  | SOLE |  | 23155 | 0 | 0 |
| VAXCYTE INC | COM | 92243G108 |  | 3085641 | 53100 | SH | Call | SOLE |  | 53100 | 0 | 0 |
| VAXCYTE INC | COM | 92243G108 |  | 1456876 | 25071 | SH |  | SOLE |  | 25071 | 0 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 |  | 1714714 | 3840 | SH |  | SOLE |  | 3840 | 0 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 |  | 41572874 | 93100 | SH | Call | SOLE |  | 93100 | 0 | 0 |
| VIKING THERAPEUTICS INC | COM | 92686J106 |  | 17089390 | 525181 | SH |  | SOLE |  | 525181 | 0 | 0 |
| VIKING THERAPEUTICS INC | COM | 92686J106 |  | 21450368 | 659200 | SH | Call | SOLE |  | 659200 | 0 | 0 |
| VIR BIOTECHNOLOGY INC | COM | 92764N102 |  | 795648 | 88800 | SH | Call | SOLE |  | 88800 | 0 | 0 |
| VISTAGEN THERAPEUTICS INC | COM | 92840H400 |  | 60252 | 105428 | SH |  | SOLE |  | 105428 | 0 | 0 |
| VOYAGER THERAPEUTICS INC | COM | 92915B106 |  | 579000 | 150000 | SH | Call | SOLE |  | 150000 | 0 | 0 |
| VOYAGER THERAPEUTICS INC | COM | 92915B106 |  | 1635258 | 423642 | SH |  | SOLE |  | 423642 | 0 | 0 |
| XERIS BIOPHARMA HOLDINGS INC | COM | 98422E103 |  | 769927 | 132746 | SH |  | SOLE |  | 132746 | 0 | 0 |
| ZYMEWORKS INC | COM | 98985Y108 |  | 3558985 | 142132 | SH |  | SOLE |  | 142132 | 0 | 0 |

---