# EDGAR Filing Document

**Accession Number:** 0001702123
**File Stem:** 0001104659-26-058766
**Filing Date:** 2026-5
**Character Count:** 120588
**Document Hash:** b57010a099a5850eeafacdd22c1e1f8d
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-26-058766.hdr.sgml**: 20260511

**ACCESSION NUMBER**: 0001104659-26-058766

**CONFORMED SUBMISSION TYPE**: 6-K

**PUBLIC DOCUMENT COUNT**: 7

**CONFORMED PERIOD OF REPORT**: 20260331

**FILED AS OF DATE**: 20260511

**DATE AS OF CHANGE**: 20260511

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Cardiol Therapeutics Inc.
- **CENTRAL INDEX KEY:** 0001702123
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** A6
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 6-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-40712
- **FILM NUMBER:** 26964611

**BUSINESS ADDRESS:**
- **STREET 1:** 602-2265 UPPER MIDDLE ROAD EAST
- **CITY:** OAKVILLE
- **STATE:** A6
- **ZIP:** L6H 0G5
- **BUSINESS PHONE:** 289-910-0850

**MAIL ADDRESS:**
- **STREET 1:** 602-2265 UPPER MIDDLE ROAD EAST
- **CITY:** OAKVILLE
- **STATE:** A6
- **ZIP:** L6H 0G5

**UNITED STATES<br> SECURITIES AND EXCHANGE COMMISSION**<br> Washington, D.C. 20549

**FORM 6-K**

**REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16<br> UNDER THE SECURITIES EXCHANGE ACT OF 1934**

For the month of **May 2026**

Commission File Number: **001-40712**

**<u>Cardiol Therapeutics Inc.</u>** <br> (Translation of registrant's name into English)

**<u>602-2265 Upper Middle Road East, Oakville, Ontario, Canada L6H 0G5</u>**<br> (Address of principal executive offices)

Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.

◻ Form 20-F ⌧ Form 40-F

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1): ◻

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7): ◻

**<u>SUBMITTED HEREWITH</u>**

<u>Exhibits</u>

---

| | |
|:---|:---|
| [99.1](tm2614096d1_ex99-1.htm) | [Condensed Interim Consolidated Financial Statements Three months ended March 31, 2026](tm2614096d1_ex99-1.htm) |
| [99.2](tm2614096d1_ex99-2.htm) | [Management's Discussion and Analysis Three months ended March 31, 2026](tm2614096d1_ex99-2.htm) |
| [99.3](tm2614096d1_ex99-3.htm) | [Form 52-109F2 Certification of Interim Filings - CEO](tm2614096d1_ex99-3.htm) |
| [99.4](tm2614096d1_ex99-4.htm) | [Form 52-109F2 Certification of Interim Filings - CFO](tm2614096d1_ex99-4.htm) |

---

**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

---

| | | | |
|:---|:---|:---|:---|
|  | **CARDIOL THERAPEUTICS INC.** | **CARDIOL THERAPEUTICS INC.** | **CARDIOL THERAPEUTICS INC.** |
|  | (Registrant) | (Registrant) | (Registrant) |
| Date: May 11, 2026 | By: | */s/ Christopher Waddick* | */s/ Christopher Waddick* |
|  |  | Name: | Christopher Waddick |
|  |  | Title: | Chief Financial Officer |

---

## Exhibit 99.1

**Exhibit 99.1**

![](tm2614096d1_ex99-1img001.jpg)

------

**CARDIOL THERAPEUTICS INC.**

**CONDENSED INTERIM CONSOLIDATED FINANCIAL STATEMENTS**

**THREE MONTHS ENDED MARCH 31, 2026**

**(EXPRESSED IN CANADIAN DOLLARS)**

**(UNAUDITED)**

------

**Cardiol Therapeutics Inc.**<br> **Condensed Interim Consolidated Statements of Financial Position**<br> **(Expressed in Canadian Dollars)**<br> **Unaudited**<br>

---

| | | |
|:---|:---|:---|
|  | **As at <br> March 31,<br> 2026** | **As at<br> December 31,<br> 2025** |
| **ASSETS** |  |  |
| **Current assets** |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Cash and cash equivalents (note 3) | $**27673191** | $21416684 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accounts receivable | **70076** | 55727 |
| &nbsp;&nbsp;&nbsp;&nbsp;Other receivables | **269630** | 170468 |
| &nbsp;&nbsp;&nbsp;&nbsp;Prepaid expenses | **3254741** | 1858961 |
| **Total current assets** | **31267638** | 23501840 |
| **Non-current assets** |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Property and equipment (note 4) | **138969** | 118093 |
| **Total assets** | $**31406607** | $23619933 |
| **EQUITY AND LIABILITIES** |  |  |
| **Current liabilities** |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Accounts payable and accrued liabilities | $**3419508** | $3478825 |
| &nbsp;&nbsp;&nbsp;&nbsp;Current portion of lease liability (note 5) | **39792** | 38347 |
| &nbsp;&nbsp;&nbsp;&nbsp;Derivative liability (note 6) | **3667386** | 2137867 |
| **Total current liabilities** | **7126686** | 5655039 |
| **Non-current liabilities** |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Lease liability (note 5) | **76616** | 87176 |
| **Total liabilities** | **7203302** | 5742215 |
| **Equity** |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Share capital (note 7) | **212802439** | 201866449 |
| &nbsp;&nbsp;&nbsp;&nbsp;Warrants (note 9) | **2820121** |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Contributed surplus | **32472309** | 29084244 |
| &nbsp;&nbsp;&nbsp;&nbsp;Deficit | **(223891564)** | (213072975) |
| **Total equity** | **24203305** | 17877718 |
| **Total equity and liabilities** | $**31406607** | $23619933 |

---

The accompanying notes are an integral part of these unaudited condensed interim consolidated financial statements.

Commitments (note 11)

Subsequent events (notes 8 and 9)

---

| | |
|:---|:---|
| **Approved on behalf of the Board:** |  |
| "*David Elsley*", Director | "*Guillermo Torre-Amione*", Director |

---

**Cardiol Therapeutics Inc.**<br> **Condensed Interim Consolidated Statements of Loss and Comprehensive Loss**<br> **(Expressed in Canadian Dollars)**<br>

---

| | | |
|:---|:---|:---|
|  | **Three Months<br> Ended<br> March 31,<br> 2026** | **Three Months<br> Ended<br> March 31,<br> 2025** |
| **Operating expenses (notes 8, 12, 13)** |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;General and administration (note 12) | $**4757383** | $4671651 |
| &nbsp;&nbsp;&nbsp;&nbsp;Research and development (note 12) | **4949411** | 3757412 |
| &nbsp;&nbsp;&nbsp;&nbsp;Loss before other income (expenses) | **(9706794)** | (8429063) |
| &nbsp;&nbsp;&nbsp;&nbsp;Interest income (note 3) | **200724** | 248269 |
| &nbsp;&nbsp;&nbsp;&nbsp;Gain (loss) on foreign exchange | **217000** | (106859) |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in derivative liability (note 6) | **(1529519)** | - |
| **Net loss and comprehensive loss for the period** | $**(10818589)** | $(8287653) |
| **Basic and diluted net loss per share (note 10)** | $**(0.10)** | $(0.10) |
| **Weighted average number of common shares outstanding** | **108987584** | 82608992 |

---

The accompanying notes are an integral part of these unaudited condensed interim consolidated financial statements.

**Cardiol Therapeutics Inc.**<br> **Condensed Interim Consolidated Statements of Cash Flows**<br> **(Expressed in Canadian Dollars)**<br> **Unaudited**<br>

---

| | | |
|:---|:---|:---|
|  | **Three Months**<br>**Ended**<br>**March 31,**<br>**2026** | **Three Months**<br>**Ended**<br>**March 31,**<br>**2025** |
| **Operating activities** |  |  |
| Net loss and comprehensive loss for the period | $**(10818589)** | $(8287653) |
| Adjustments for: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Depreciation of property and equipment | **26709** | 24986 |
| &nbsp;&nbsp;&nbsp;&nbsp;Share-based compensation (note 8) | **1842835** | 1146974 |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in derivative liability | **1529519** |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Unrealized foreign exchange (gain)/loss on cash | **(221941)** | 107778 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accretion on lease liability | **4729** | 5972 |
| Changes in non-cash working capital items: | Changes in non-cash working capital items: | Changes in non-cash working capital items: |
| &nbsp;&nbsp;&nbsp;&nbsp;Accounts receivable | **(14349)** | 24406 |
| &nbsp;&nbsp;&nbsp;&nbsp;Other receivables | **(99162)** | (9475) |
| &nbsp;&nbsp;&nbsp;&nbsp;Prepaid expenses | **(1395780)** | (906450) |
| &nbsp;&nbsp;&nbsp;&nbsp;Accounts payable and accrued liabilities | **1628398** | 739695 |
| **Net cash used in operating activities** | **(7517631)** | (7153767) |
| **Investing activities** |  |  |
| Purchase of property and equipment | **(47585)** | (11939) |
| **Net cash used in investing activities** | **(47585)** | (11939) |
| **Financing activities** |  |  |
| Issuance of units | **14850001** |  |
| Share issuance costs | **(1236375)** |  |
| Payment of lease liability | **(13844)** | (13844) |
| **Net cash provided by (used in) financing activities** | **13599782** | (13844) |
| **Net change in cash and cash equivalents** | **6034566** | (7179550) |
| **Cash and cash equivalents, beginning of period** | **21416684** | 30580029 |
| **Impact of foreign exchange on cash and cash equivalents** | **221941** | (107778) |
| **Cash and cash equivalents, end of period** | $**27673191** | $23292701 |
| **Supplemental information** |  |  |
| Accounts payable and accrued liabilities settled through equity | $**1687715** | $- |

---

The accompanying notes are an integral part of these unaudited condensed interim consolidated financial statements.

**Cardiol Therapeutics Inc.**<br> **Condensed Interim Consolidated Statements of Changes in Equity**<br> **(Expressed in Canadian Dollars)**<br> **Unaudited**<br>

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **Share capital** | **Share capital** | | | | |
|  | **Number** | **Amount** |<br>**Warrants** | **Contributed**<br>**surplus** |<br>**Deficit** |<br>**Total** |
| **Balance, December 31, 2024** | **82608992** | $**179335421** | $**-** | $**24647163** | $**(179254101)** | $**24728483** |
| &nbsp;&nbsp;&nbsp;Share-based compensation (note 8) |  |  |  | 1146974 |  | 1146974 |
| &nbsp;&nbsp;&nbsp;Net loss and comprehensive loss for the period | - | - | - | - | (8287653) | (8287653) |
| **Balance, March 31, 2025** | **82608992** | $**179335421** | $**-** | $**25794137** | $**(187541754)** | $**17587804** |
| **Balance, December 31, 2025** | **100257009** | $**201866449** | $**-** | $**29084244** | $**(213072975)** | $**17877718** |
| &nbsp;&nbsp;&nbsp;Issuance of units | 11423078 | 14850001 |  |  |  | 14850001 |
| &nbsp;&nbsp;&nbsp;Share issuance costs |  | (980255) | (256120) |  |  | (1236375) |
| &nbsp;&nbsp;&nbsp;Fair value of warrants |  | (3076241) | 3076241 |  |  |  |
| &nbsp;&nbsp;&nbsp;Performance share units exercised | 191997 | 142485 |  | (142485) |  |  |
| &nbsp;&nbsp;&nbsp;Share-based compensation (note 8) |  |  |  | 3530550 |  | 3530550 |
| &nbsp;&nbsp;&nbsp;Net loss and comprehensive loss for the period | - | - | - | - | (10818589) | (10818589) |
| **Balance, March 31, 2026** | **111872084** | $**212802439** | $**2820121** | $**32472309** | $**(223891564)** | $**24203305** |

---

The accompanying notes are an integral part of these unaudited condensed interim consolidated financial statements.

**Cardiol Therapeutics Inc.**

**Notes to Condensed Interim Consolidated Financial Statements**

**Three Months Ended March 31, 2026**

**(Expressed in Canadian Dollars) <br> Unaudited**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**1.** **Nature of operations** 

Cardiol Therapeutics Inc. was incorporated under the laws of the Province of Ontario on January 19, 2017. The Corporation's registered and legal office is located at 2265 Upper Middle Rd. E., Suite 602, Oakville, Ontario, L6H 0G5, Canada.

Cardiol Therapeutics Inc. and its subsidiary (the "Corporation" or "Cardiol") is a late-stage life sciences company focused on advancing the development of anti-inflammatory and anti-fibrotic therapies for heart disease. The Company's lead small-molecule drug candidate, CardiolRx™, modulates inflammasome pathway activation, an intracellular process known to play an important role in the development and progression of inflammation and fibrosis associated with pericarditis, myocarditis, and heart failure.

On December 20, 2018, the Corporation completed its initial public offering on the Toronto Stock Exchange (the "TSX") and its common shares commenced trading on the TSX under the symbol "CRDL". On August 10, 2021, the Corporation's common shares commenced trading on The Nasdaq Capital Market under the symbol "CRDL".

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**2.** **Material accounting policy information** 

*Statement of compliance*

These unaudited condensed interim consolidated financial statements have been prepared in accordance with International Accounting Standard 34, Interim Financial Reporting. Accordingly, they do not include all of the information required for full annual financial statements required by International Financial Reporting Standards as issued by the International Accounting Standards Board (IASB) ("IFRS Accounting Standards").

These unaudited condensed interim consolidated financial statements have been prepared on a historical cost basis. In addition, these unaudited condensed interim consolidated financial statements have been prepared using the accrual basis of accounting except for cash flow information.

The policies applied in these unaudited condensed interim consolidated financial statements are based on IFRS Accounting Standards issued and outstanding as of May 11, 2026, the date the Board of Directors approved the statements. The same accounting policies and methods of computation are followed in these unaudited condensed interim consolidated financial statements as compared with the most recent annual consolidated financial statements as at and for the year ended December 31, 2025.

Any subsequent changes to IFRS Accounting Standards that are given effect in the Corporation's annual consolidated financial statements for the year ending December 31, 2026, could result in restatement of these unaudited condensed interim consolidated financial statements.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**3.** **Cash and cash equivalents** 

Interest earned on cash and cash equivalents for the three months ended March 31, 2026, amounted to $200,724 (three months ended March 31, 2025 - $248,269).

**Cardiol Therapeutics Inc.**

**Notes to Condensed Interim Consolidated Financial Statements**

**Three Months Ended March 31, 2026**

**(Expressed in Canadian Dollars) Unaudited**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**4.** **Property and equipment** 

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| **Cost** | **Right-of-<br> use asset** | **Equipment** | **Leasehold<br> improvements** | **Office<br> equipment** | **Computer<br> equipment** | **Total** |
| Balance, December 31, 2024 | $341238 | $172954 | $237248 | $66864 | $149947 | $968251 |
| Additions | - | - | - | 1937 | 22547 | 24484 |
| Balance, December 31, 2025 | 341238 | 172954 | 237248 | $68801 | $172494 | $992735 |
| Additions | - | 43331 | - | - | 4254 | 47585 |
| Balance, March 31, 2026 | $341238 | $216285 | $237248 | $68801 | $176748 | $1040320 |

---

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| **Accumulated Depreciation** | **Right-of-<br> use asset** | **Equipment** | **Leasehold<br> improvements** | **Office<br> equipment** | **Computer<br> equipment** | **Total** |
| Balance, December 31, 2024 | $260652 | $130647 | $237248 | $45657 | $98455 | $772659 |
| Depreciation for the year | 63984 | 12692 | - | 4435 | 20872 | 101983 |
| Balance, December 31, 2025 | $324636 | $143339 | $237248 | $50092 | $119327 | $874642 |
| Depreciation for the period | 15996 | 5471 | - | 935 | 4307 | 26709 |
| Balance, March 31, 2026 | $340632 | $148810 | $237248 | $51027 | $123634 | $901351 |

---

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| **Carrying value** | **Right-of-<br> use asset** | **Equipment** | **Leasehold<br> improvements** | **Office<br> equipment** | **Computer<br> equipment** | **Total** |
| Balance, December 31, 2025 | $16602 | $29615 | $&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;- | $18709 | $53167 | $118093 |
| Balance, March 31, 2026 | $606 | $67475 | $- | $17774 | $53114 | $138969 |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**5.** **Lease liability** 

---

| | |
|:---|:---|
|  | **Carrying<br> Value** |
| Balance, December 31, 2024 | $158532 |
| Repayments | (55376) |
| Accretion | 22367 |
| Balance, December 31, 2025 | $125523 |
| Repayments | (13844) |
| Accretion | 4729 |
| Balance, March 31, 2026 | $116408 |
| Current portion | 39792 |
| Long-term portion | $76616 |

---

**Cardiol Therapeutics Inc.**

**Notes to Condensed Interim Consolidated Financial Statements**

**Three Months Ended March 31, 2026**

**(Expressed in Canadian Dollars) Unaudited**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**6.** **Derivative liability** 

In October 2025, the Corporation issued 5,712,500 warrants as part of a unit financing. Each warrant is exercisable into one common share at the price of US$1.35 per share for a period of two years from closing. The original estimated fair value of $3,089,610 was assigned to the 5,712,500 warrants issued by using a fair value market technique incorporating the Black-Scholes option pricing model, with the following assumptions: a share price of $1.46, a risk-free interest rate of 2.37%; an expected volatility factor of 81%; and an expected life of 2 years. The only significant unobservable input is the volatility, which could cause an increase or decrease in fair value. The warrants have been classified as a derivative liability on the statement of financial position and are re-valued at each reporting date, as the warrants were issued in a currency other than the Corporation's functional currency. As at March 31, 2026, the fair value of the derivative liability was $3,667,386 (December 31, 2025 - $2,137,867), resulting in an increase in the value of the derivative liability for the three months ended March 31, 2026, of $1,529,519. As at March 31, 2026, all 5,712,500 warrants remain outstanding.

Significant assumptions used in determining the fair value of the derivative warrant liabilities are as follows:

---

| | |
|:---|:---|
|  | **Three Months<br> Ended**<br>**March 31,**<br>**2026** |
| Share price | $1.89 |
| Exercise price | $1.88 |
| Risk-free interest rate | 2.82% |
| Expected volatility | 67% |
| Expected life in years | 1.55 |
| **Expected dividend yield** | Nil |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**7.** **Share capital** 

a) Authorized share capital

The authorized share capital consists of an unlimited number of common shares. The common shares do not have a par value. All issued shares are fully paid.

b) Common shares issued

---

| | | |
|:---|:---|:---|
|  | **Number of**<br>**common<br> shares** |<br>**Amount** |
| Balance, December 31, 2024 and March 31, 2025 | 82608992 | $179335421 |
| Balance, December 31, 2025 | 100257009 | $201866449 |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of units (i) | 11423078 | 14850001 |
| &nbsp;&nbsp;&nbsp;&nbsp;Share issuance costs (i) |  | (980255) |
| &nbsp;&nbsp;&nbsp;&nbsp;Fair value of warrants (i) |  | (3076241) |
| &nbsp;&nbsp;&nbsp;&nbsp;Performance share units exercised (note 8) | 191997 | 142485 |
| Balance, March 31, 2026 | 111872084 | $212802439 |

---

**Cardiol Therapeutics Inc.**

**Notes to Condensed Interim Consolidated Financial Statements**

**Three Months Ended March 31, 2026**

**(Expressed in Canadian Dollars) Unaudited**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**7.** **Share capital (continued)** 

b) Common shares issued (continued)

(i) In January 2026, the Corporation completed a unit financing by issuing 11,423,078 common share units at $1.30 per unit for gross proceeds of $14,850,001. Each unit consisted of one common share and one-half of one common share purchase warrant. Each whole warrant is exercisable into one common share at the price of $1.75 per share for a period of 2 years from closing. Share issuance costs of $1,236,375 were incurred, of which $256,120 was allocated to warrants.

The fair value of $3,076,241 was assigned to the 5,711,539 warrants issued as part of the units as estimated by using a fair market value technique incorporating the Black-Scholes option pricing model based on the assumptions below:

---

| | |
|:---|:---|
| Share price | $1.41 |
| Exercise price | $1.75 |
| Risk-free interest rate | 2.60% |
| Expected volatility | 80% |
| Expected life in years | 2.00 |
| Expected dividend yield | Nil |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**8.** **Share-based payments** 

The Corporation has adopted an Omnibus Equity Incentive Plan in accordance with the policies of the TSX, which permits the grant or issuance of options, Restricted Share Units ("RSUs"), Performance Share Units ("PSUs"), and Deferred Share Units ("DSUs"), as well as other share-based payment arrangements. The maximum number of shares that may be issued upon the exercise or settlement of awards granted under the plan may not exceed 15% of the Corporation's issued and outstanding shares from time to time. The Board of Directors determines the price per common share and the number of common shares which may be allotted to directors, officers, employees, and consultants, and all other terms and conditions of the option, subject to the rules of the TSX.

During the three months ended March 31, 2026, the total expenses related to share-based compensation amounted to $1,842,835 (three months ended March 31, 2025 - $1,146,974). All outstanding awards are settleable with common shares and not cash.

<u>(a) Stock Options</u>

---

| | | |
|:---|:---|:---|
|  | **Number of**<br>**stock options** | **Weighted average**<br>**exercise price ($)** |
| Balance, December 31, 2024 | 1487500 | $2.76 |
| Issued | 1200000 | 1.63 |
| Expired | (170000) | 2.68 |
| Balance, March 31, 2025 | 2517500 | $2.22 |
| Balance, December 31, 2025 and March 31, 2026 | 4782500 | $1.73 |

---

**Cardiol Therapeutics Inc.**

**Notes to Condensed Interim Consolidated Financial Statements**

**Three Months Ended March 31, 2026**

**(Expressed in Canadian Dollars) Unaudited**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**8.** **Share-based payments (continued)** 

<u>(a)</u> <u>Stock Options (continued)</u>

The following table reflects the actual stock options issued and outstanding as of March 31, 2026:

---

| | | | | |
|:---|:---|:---|:---|:---|
| **Expiry date** | **Exercise <br> price ($)** | **Weighted average<br> remaining<br> contractual<br> life (years)** | **Number of <br> options <br> outstanding** | **Number of <br> options<br> vested<br> (exercisable)** |
| April 1, 2026 (ii) | 5.77 | 0.00 | 60000 | 60000 |
| December 8, 2026 | 3.59 | 0.69 | 325000 | 325000 |
| January 11, 2027 | 2.18 | 0.78 | 220000 | 220000 |
| March 1, 2027 | 2.56 | 0.92 | 200000 | 200000 |
| March 9, 2027 | 1.57 (i) | 0.94 | 200000 | 200000 |
| May 12, 2027 | 1.46 | 1.12 | 70000 | 70000 |
| September 13, 2027 | 1.61 | 1.45 | 207500 | 207500 |
| July 21, 2028 | 1.67 | 2.31 | 50000 | 25000 |
| July 7, 2029 | 2.07 | 3.27 | 30000 | 10000 |
| August 19, 2029 | 1.50 | 3.39 | 30000 | 10000 |
| May 25, 2030 | 1.52 (i) | 4.15 | 120000 | 90000 |
| May 25, 2030 | 2.12 | 4.15 | 100000 | 75000 |
| May 29, 2030 | 1.61 (i) | 4.16 | 60000 |  |
| December 2, 2030 | 1.40 | 4.68 | 2620000 |  |
| December 2, 2030 | 1.39 (i) | 4.68 | 490000 | - |
|  | 1.73 | 3.59 | 4782500 | 1492500 |

---

(i) Denotes exercise price in USD; these amounts were translated to CAD for presentation purposes at the March 31, 2026 rate of 1.39.

(ii) Subsequent to March 31, 2026, 60,000 options expired unexercised.

<u>(b)</u> <u>Performance Share Units</u>

---

| | |
|:---|:---|
|  | **Number of<br> PSUs** |
| Balance, December 31, 2024 and March 31, 2025 | - |
| Balance, December 31, 2025 | 2167284 |
| Issued (i), (ii) | 1503013 |
| Redeemed (iii) | (191997) |
| Balance, March 31, 2026 | 3478300 |

---

(i) Grants of PSUs require completion of certain performance criteria specific to each grant. As the fair value of the services for certain PSUs issued cannot be reliably measured, the fair value was determined on the basis of the equity issued. The fair value of PSUs granted was determined based on the Corporation's share price, adjusted by the estimated likelihood of the performance conditions being met.

**Cardiol Therapeutics Inc.**

**Notes to Condensed Interim Consolidated Financial Statements**

**Three Months Ended March 31, 2026**

**(Expressed in Canadian Dollars) Unaudited**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**8.** **Share-based payments (continued)** 

<u>(b) Performance Share Units (continued)</u>

(ii) During the three months ended March 31, 2026, the Corporation settled $1,687,716 of accounts payable and accrued liabilities through PSUs valued at $2,201,034. Loss on settlement of debt of $513,318 is recorded in research and development.

(iii) The weighted average share price on date of exercise was $1.36.

The following table reflects the actual PSUs issued and outstanding as of March 31, 2026:

---

| | | | |
|:---|:---|:---|:---|
| **Expiry date** | **Weighted average<br> remaining<br> contractual<br> life (years)** | **Number of<br> PSUs<br> outstanding** | **Number of<br> PSUs<br> vested<br> (exercisable)** |
| June 30, 2026 | 0.25 | 1329671 | 1279671 |
| December 31, 2026 | 0.75 | 148629 |  |
| October 31, 2027 | 1.59 | 2000000 | - |
|  | 1.04 | 3478300 | 1279671 |

---

(i) Subsequent to March 31, 2026, 872,981 PSUs were issued.

(ii) Subsequent to March 31, 2026, 2,037,656 PSUs were redeemed.

(iii) Subsequent to March 31, 2026, 2,000,000 PSUs expired unexercised.

<u>(c) Restricted Share Units</u>

---

| | |
|:---|:---|
|  | **Number of<br> RSUs** |
| Balance, December 31, 2024 and March 31, 2025 | 4,852,299 |
| Balance, December 31, 2025 and March 31, 2026 | 4,763,443 |

---

The following table reflects the actual RSUs issued and outstanding as of March 31, 2026:

---

| | | | |
|:---|:---|:---|:---|
| **Expiry date** | **Weighted average <br> remaining<br> contractual<br> life (years)** | **Number of<br> RSUs<br> outstanding** | **Number of <br> RSUs<br> vested<br> (exercisable)** |
| July 10, 2027 | 1.28 | 3103248 | 1438252 |
| July 31, 2027 | 1.33 | 1291058 | 1291058 |
| October 31, 2027 | 1.59 | 32874 | 32874 |
| September 30, 2030 | 4.50 | 147242 |  |
| December 30, 2030 | 4.75 | 189021 | - |
|  | 1.53 | 4763443 | 2762184 |

---

**Cardiol Therapeutics Inc.**

**Notes to Condensed Interim Consolidated Financial Statements**

**Three Months Ended March 31, 2026**

**(Expressed in Canadian Dollars) Unaudited**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**9.** **Warrants** 

---

| | | |
|:---|:---|:---|
|  | **Number of<br> warrants** | **Amount** |
| Balance, December 31, 2024 and March 31, 2025 | - | $- |
| Balance, December 31, 2025 | 5712500 | $- |
| Issued (Note 7) | 5711539 | 2820121 |
| Balance, March 31, 2026 | 11424039 | $2820121 |

---

The following table reflects the actual warrants issued and outstanding as of March 31, 2026:

---

| | | | |
|:---|:---|:---|:---|
| **Expiry date** | **Exercise<br> price ($)** | **Remaining<br> contractual<br> life (years)** | **Warrants<br> exercisable** |
| October 17, 2027 (ii) | 1.88 (i) | 1.55 | 4977500 |
| October 20, 2027 | 1.88 (i) | 1.56 | 735000 |
| January 23, 2028 | 1.75 | 1.82 | 5711539 |
|  | 1.81 | 1.68 | 11424039 |

---

(i) Warrants carry an exercise price of US$1.35. This amount was translated to CAD for presentation purposes at the March 31, 2026 rate of 1.39. These warrants are classified as a derivative liability on the statement of financial position (see note 6).

(ii) Subsequent to March 31, 2026, 1,350,000 warrants were exercised.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**10.** **Loss per share** 

For the three months ended March 31, 2026, basic and diluted loss per share has been calculated based on the loss attributable to common shareholders of $10,818,589 (three months ended March 31, 2025 - $8,287,653) and the weighted average number of common shares outstanding of 108,987,584 (three months ended March 31, 2025 - 82,608,992). Diluted loss per share did not include the effect of stock options, PSUs, RSUs, and warrants as they are anti-dilutive.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**11.** **Commitments** 

(i) The Corporation has leased premises with third parties. The minimum committed lease payments, which include the lease liability payments shown as base rent, are approximately as follows:

---

| | | | |
|:---|:---|:---|:---|
|  | **Base rent** | **Variable rent** | **Total** |
| 2026.0 | $41532 | $38884 | $80416 |
| 2027.0 | 55376 | 51846 | 107222 |
| 2028.0 | 46146 | 43206 | 89352 |
|  | $143054 | $133936 | $276990 |

---

**Cardiol Therapeutics Inc.**

**Notes to Condensed Interim Consolidated Financial Statements**

**Three Months Ended March 31, 2026**

**(Expressed in Canadian Dollars) <br> Unaudited**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**11.** **Commitments (continued)** 

(ii) The Corporation has signed various agreements with consultants to provide services. Under the agreements, the Corporation has the following remaining commitments.

---

| | |
|:---|:---|
| 2026 | $210922 |
| 2027 | 34990 |
| Total | $245912 |

---

(iii) Pursuant to the terms of agreements with various other contract research organizations, the Corporation is committed for the following contract research services:

---

| | |
|:---|:---|
| 2026 | $1135032 |
| 2027 | 508360 |
| 2028 | 45833 |
| 2029 | 22196 |
| Total | $1711421 |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**12.** **Operating expenses** 

The following details highlight certain non-cash components of the research and development and general and administration expenses. Remaining research and development and operating expenses include personnel costs and expenses paid to third parties:

---

| | | |
|:---|:---|:---|
|  | **Three Months<br> Ended<br> March 31,<br> 2026** | **Three Months<br> Ended<br> March 31,<br> 2025** |
| General and administration expenses |  |  |
| Depreciation of property and equipment | $**26709** | $24986 |
| Non-cash share-based compensation | **1106113** | 838346 |
| Research and development expenses |  |  |
| Non-cash share-based compensation | $**736722** | $308628 |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**13.** **Related party transactions** 

Key management personnel are those persons having authority and responsibility for planning, directing, and controlling the activities of the Corporation directly or indirectly, and include any directors (executive and non-executive) of the Corporation. Remuneration of directors and key management personnel of the Corporation was as follows:

---

| | | |
|:---|:---|:---|
|  | **Three Months<br> Ended<br> March 31,<br> 2026** | **Three Months<br> Ended<br> March 31,<br> 2025** |
| Salaries and benefits | $**1301084** | $1305013 |
| Share-based payments | **403563** | 468960 |
|  | $**1704647** | $1773973 |

---

As at March 31, 2026, $76,154 (December 31, 2025 - $nil) was owed to directors and key management personnel.

## Exhibit 99.2

**Exhibit 99.2**![](tm2614096d1_ex99-2img001.jpg)

------

**CARDIOL THERAPEUTICS INC.**

**MANAGEMENT'S DISCUSSION AND ANALYSIS**

**THREE MONTHS ENDED MARCH 31, 2026**

------

**MANAGEMENT'S DISCUSSION AND ANALYSIS**

**Introduction**

The following management's discussion and analysis ("MD&A") of the financial condition and results of the operations of Cardiol Therapeutics Inc. and its subsidiary (the "Corporation" or "Cardiol") constitutes management of the Corporation's ("Management") review of the factors that affected the Corporation's financial and operating performance for the three months ended March 31, 2026 (the "2026 Fiscal Period"). This discussion should be read in conjunction with the consolidated financial statements for the years ended December 31, 2025, and 2024, and the unaudited condensed interim consolidated financial statements for the three months ended March 31, 2026 ("Financial Statements"), together with the respective notes thereto. The Financial Statements and the financial information contained in this MD&A are derived from the Financial Statements prepared in accordance with International Accounting Standard 34, Interim Financial Reporting. Accordingly, they do not include all of the information required for full annual financial statements required by International Financial Reporting Standards and International Accounting Standard as issued by the International Accounting Standards Board (IASB) and Interpretations (collectively "IFRS Accounting Standards"). In the opinion of Management, all adjustments (which consist only of normal recurring adjustments) considered necessary for a fair presentation have been included.

This MD&A is dated May 11, 2026. All dollar amounts in this MD&A are reported in Canadian dollars, unless otherwise stated. Unless otherwise noted or the context indicates otherwise, the terms "we", "us", "our", "Cardiol", the "Company" or the "Corporation" refer to Cardiol Therapeutics Inc. and its subsidiary.

This MD&A is presented current to May 11, 2026, unless otherwise stated. The financial information presented in this MD&A is derived from the Financial Statements. This MD&A contains forward-looking statements that involve risks, uncertainties, and assumptions, including statements regarding anticipated developments in future financial periods and our plans and objectives. There can be no assurance that such information will prove to be accurate, and readers are cautioned not to place undue reliance on such forward-looking statements. See "Forward-Looking Statements" and "Risk Factors".

**Forward-Looking Information**

This MD&A includes certain "forward looking information" within the meaning of applicable Canadian securities legislation and "forward-looking statements" within the meaning of applicable U.S. securities legislation (collectively, "Forward-Looking Information"). Forward-looking information can be identified by words or phrases such as: "may", "might", "could", "will", "expect", "anticipate", "estimate", "intend", "plan", "indicate", "seek", "believe", "predict", or "likely", or the negative of these terms, or other similar expressions or references to future periods. All information other than historical facts, included in this MD&A that address activities, events or developments that the Corporation expects or anticipates will or may occur in the future, including such things as future business strategy, competitive strengths, goals, expansion and growth of the Corporation's business, operations, plans and other such matters is intended to identify forward-looking information. Statements containing forward-looking information are not historical facts.

The Corporation has based the forward-looking information on its current expectations and projections about future events and financial trends that it believes might affect its financial condition, results of operations, business strategy, and financial needs. The forward-looking information includes, among other things, statements relating to:

· our anticipated cash needs, and the need for additional financing;

· our development of our product candidates for use in testing, research, pre-clinical
studies, clinical studies, and commercialization;

· our ability to develop new routes of administration of our product candidates,
including parenteral, for use in testing, research, pre-clinical studies, clinical studies, and commercialization, if approved;

· our ability to develop new formulations of our product candidates for use
in testing, research, pre-clinical studies, clinical studies, and commercialization, if approved;

· the successful development and commercialization, if approved, of our current product candidates
and the addition of future products and product candidates;

· the ability of our product delivery technologies to deliver our product candidates
to inflamed and/or fibrotic tissue;

· our intention to build a pharmaceutical brand and our products focused on
addressing inflammation and fibrosis in heart disease, including, but not limited to, acute myocarditis, recurrent pericarditis, and heart
failure;

· the expected medical benefits, viability, safety,
efficacy, effectiveness, and dosing of our product candidates;

· our patents and intellectual property, including,
but not limited to, our (a) ability to procure, defend, and/or enforce our intellectual property relating to our products, product
formulations, routes of administration, product candidates, and associated uses, methods, and/or processes, and (b) freedom to operate;

· our competitive position and the regulatory environment
in which we operate;

· the molecular targets and mechanism of action
of our product candidates;

· our financial position; our business strategy;
our growth strategies; our operations; our financial results; our dividend policy; our plans and objectives; and

· expectations of future results, performance,
milestones, achievements, prospects, opportunities, or the market in which we operate.

In addition, any statements that refer to expectations, intentions, projections, or other characterizations of future events or circumstances contain forward-looking information. Forward-looking information is based on certain assumptions and analyses made by the Corporation in light of the experience and perception of historical trends, current conditions, and expected future developments and other factors it believes are appropriate and are subject to risks and uncertainties. Although we believe that the assumptions underlying these statements are reasonable, they may prove to be incorrect, and we cannot assure that actual results will be consistent with this forward-looking information. Given these risks, uncertainties, and assumptions, prospective investors should not place undue reliance on this forward-looking information. Whether actual results, performance, or achievements will conform to the Corporation's expectations and predictions is subject to a number of known and unknown risks, uncertainties, assumptions, and other factors, including those listed under "*Risk Factors*", which include:

· the inherent uncertainty of product development including testing, research,
pre-clinical studies, and clinical trials;

· our requirement for additional financing;

· our negative cash flow from operations;

· our history of losses;

· dependence on the success of our product candidates which may not generate
revenue, if approved;

· reliance on management, loss of members of management or other key personnel,
or an inability to attract new management team members;

· our ability to successfully design, initiate, execute, and complete clinical
trials, including the high cost, uncertainty, and delay of clinical trials and additional costs associated with any failed clinical trials;

· the uncertainty our investigational products will have a therapeutic benefit
in the clinical indications we are pursuing;

· potential equivocal or negative results from clinical trials and their adverse
impacts on our future commercialization efforts;

· our ability to receive and maintain regulatory exclusivities in multiple
jurisdictions, including Orphan Drug/Medicine Designations/Approvals, for our product candidates;

· delays in achievement of projected development goals;

· management of additional regulatory burdens;

· volatility in the market price for the common shares;

· failure to protect and maintain and the consequential loss of intellectual
property rights;

· third-party claims relating to misappropriation by the Corporation of their
intellectual property;

· reliance on third parties to conduct and monitor our pre-clinical studies
and clinical trials;

· our product candidates being subject to controlled substance laws which may
vary from jurisdiction to jurisdiction;

· changes in laws, regulations, and guidelines relating to our business, including
tax and accounting requirements;

· our reliance on research regarding the medical benefits, viability, safety,
efficacy, and dosing of our product candidates;

· claims for personal injury or death arising from the use of our future products
and product candidates;

· uncertainty relating to market acceptance of our product candidates, if approved;

· our lack of experience in commercializing any products, including selling,
marketing, or distributing pharmaceutical products;

· securing third-party payor reimbursement for our product candidates, if approved;

· the level of pricing and reimbursement for our product candidates, if approved;

· our dependence on contract manufacturers;

· unsuccessful collaborations with third parties;

· business disruptions affecting third-party suppliers and manufacturers;

· delays in the timing of regulatory authority decision-making, actions, and
meetings as a result of workforce re-alignment, and potentially significant reductions in workforce
or other resources, including at the United States Food and Drug Administration ("U.S. FDA") and other U.S. federal agencies;

· lack of control in future production and selling prices of our product candidates,
if approved;

· competition in our industry;

· our inability to develop new technologies and products and the obsolescence
of existing technologies and products;

· unfavorable publicity or consumer perception towards any products for which
we receive marketing authorization;

· product liability claims and product recalls;

· inability to expand our business to other jurisdictions;

· fraudulent activities of employees, contractors, and consultants;

· our reliance on key inputs and their related costs;

· difficulty associated with forecasting demand for products;

· operating risk and insurance coverage;

· our inability to manage growth;

· conflicts of interest among our officers and directors;

· managing damage to our reputation and third-party reputational risks;

· relationships with customers and third-party payors and consequential exposure
to applicable anti-kickback, fraud, and abuse and other healthcare laws;

· exposure to information systems security threats;

· no dividends for the foreseeable future;

· future sales of common shares by existing shareholders causing the market
price for the common shares to fluctuate;

· the issuance of common shares in the future causing dilution;

· events outside of our control could adversely affect our operations;

· our ability to remediate any material weakness in our internal control over
financial reporting;

· global geo-political events, and the responses of governments having a significant
effect on the world economy; and

· failure to meet regulatory or ethical expectations on environmental impact,
including climate change.

If any of these risks or uncertainties materialize, or if assumptions underlying the forward-looking information prove incorrect, actual results may vary materially from those anticipated in the forward-looking information.

Although the Corporation has attempted to identify important factors that could cause actual actions, events, or results to differ materially from those described in forward-looking information, there may be other factors that cause actions, events, or results not to be as anticipated, estimated, or intended. There can be no assurance that forward-looking information will prove to be accurate, as actual results and future events could differ materially from those anticipated. The Corporation does not undertake to update forward-looking information if circumstances or management estimates, assumptions, or opinions should change, except as required by applicable law. The reader is cautioned not to unduly rely on forward-looking information. Prospective investors shall be advised that these cautionary remarks expressly qualify all forward-looking statements attributable to the Corporation or persons acting on our behalf.

**Overview**

On December 20, 2018, the Corporation completed its initial public offering on the Toronto Stock Exchange (the "TSX"), and its common shares commenced trading on the TSX under the symbol "CRDL". On August 10, 2021, the Corporation's common shares also commenced trading on The Nasdaq Capital Market under the symbol "CRDL".

Cardiol Therapeutics Inc. is a late-stage life sciences company advancing the development of anti-inflammatory and anti-fibrotic therapies for heart disease. The Corporation's lead small molecule drug candidate, CardiolRx™ modulates inflammasome pathway activation, an intracellular process known to play an important role in the development and progression of inflammation and fibrosis associated with pericarditis, myocarditis, and heart failure.

The MAVERIC Program is evaluating CardiolRx™ for the treatment of recurrent pericarditis, an inflammatory disease of the pericardium associated with symptoms including debilitating chest pain, shortness of breath, and fatigue, which can lead to physical limitations, reduced quality of life, emergency department visits, and hospitalizations. The program comprises the completed Phase II MAvERIC-Pilot study (NCT05494788) and the ongoing pivotal Phase III MAVERIC trial (NCT06708299). The U.S. FDA has granted Orphan Drug Designation to CardiolRx™ for the treatment of pericarditis, including recurrent pericarditis.

The ARCHER Program also studied CardiolRx™ in acute myocarditis—an important cause of acute and fulminant heart failure in young adults and a leading cause of sudden cardiac death in individuals under 35 years of age. The program comprises the completed Phase II ARCHER study (NCT05180240), which evaluated the safety, tolerability, and efficacy of CardiolRx™ in this patient population.

The Company is also developing CRD-38, a novel, subcutaneously administered drug formulation intended for the treatment of inflammatory heart disease, including heart failure—a leading cause of death and hospitalization in the developed world, with associated healthcare costs in the United States exceeding US$30 billion per year1.

**Operations Highlights**

**During the 2026 Fiscal Period**

(i) In January 2026, the Corporation announced that it has surpassed 50% of the target patient enrollment in MAVERIC.

(ii) In January 2026, the Corporation announced the closing of its bought deal financing and full exercise of over-allotment option for gross proceeds of $14.85 million.

(iii) In February 2026, the Corporation announced the publication of results from its Phase II ARCHER study in ESC Heart Failure, a journal of the European Society of Cardiology.

**Subsequent to March 31, 2026**

(i) In April 2026, the Corporation announced the continued expansion of its pivotal Phase III MAVERIC trial in the United States ("U.S."), with the planned activation of up to seven additional clinical centers. The Corporation also announced that patient enrollment in MAVERIC reached 75%. Target recruitment is anticipated by the end of Q2 2026, with the potential to extend into Q3 2026 to accommodate patient enrollment from additional clinical sites.

***MAVERIC PROGRAM IN RECURRENT PERICARDITIS***

Pericarditis refers to inflammation of the pericardium (the membrane or sac that surrounds the heart), frequently resulting from a viral infection. Recurrent pericarditis is the reappearance of symptoms after a symptom-free period of at least four to six weeks following the initial acute episode of pericarditis. Patients may have multiple recurrences. Symptoms include debilitating chest pain, shortness of breath, and fatigue, resulting in physical limitations, reduced quality of life, emergency department visits, and hospitalizations. Causes of pericarditis can include infection, usually viral, systemic disorders such as autoimmune and inflammatory diseases, cancer, and post-cardiac injury syndromes. Pericarditis (and its recurrences) are symptomatic events, the diagnosis of which is based on meeting two of four criteria: chest pain; pericardial friction rub; electrocardiogram changes; and new or worsening pericardial swelling. Elevation of inflammatory markers such as C-reactive protein ("CRP"), and evidence of pericardial inflammation by an imaging technique (computed tomography scan or cardiac magnetic resonance) may help the diagnosis and the monitoring of disease activity. Although generally self-limited and not life threatening, pericarditis is diagnosed in 0.2% of all cardiovascular in-hospital admissions and is responsible for 5% of emergency room admissions for chest pain in North America and Western Europe<sup>2</sup>.

Recurrent pericarditis appears in 15% to 30% of patients following the acute index episode and usually within 18 months. Furthermore, up to 50% of patients with a recurrent episode of pericarditis experience more recurrences. Standard first-line medical therapy consists of non-steroidal anti-inflammatory drugs with or without colchicine. Corticosteroids such as prednisone are second-line therapy in patients with continued recurrence and inadequate response to conventional therapy. The only U.S. FDA-approved therapy for recurrent pericarditis, launched in 2021, is a costly subcutaneously injected interleukin-1 blocker with immunosuppressive effects. It is generally used as a third-line intervention in patients with persistent underlying disease, multiple recurrences, and an inadequate response to conventional therapy<sup>2</sup>.

On an annual basis, the number of patients in the U.S. having experienced at least one recurrence is estimated at 40,000. Approximately 60% of patients with multiple recurrences (>1) still suffer for longer than two years, and one-third are still impacted at five years. Hospitalization due to recurrent pericarditis is often associated with a 6 – 8-day length of stay and cost per stay is estimated to range between U.S.$20,000 and U.S.$30,000 in the U.S.<sup>2</sup>.

Recurrent pericarditis is a rare disease in the U.S., and in February 2024, the U.S. FDA granted Orphan Drug Designation to CardiolRx™ for the treatment of pericarditis, which includes recurrent pericarditis.

The MAVERIC Program is led by an independent Steering Committee ("SC"), consisting of international thought leaders in cardiovascular disease, including:

· **MAVERIC Program Chair: Allan Klein, MD, CM** – Director, Center for the Diagnosis and Treatment of Pericardial Diseases, and Professor of Medicine, Heart, Vascular and Thoracic
Institute, Cleveland Clinic;

· **MAVERIC Program Co-Chair: Massimo Imazio, MD, FESC** – Departments of Medicine (DMED), University of Udine and Cardiotoracic Department, University Hospital Santa Maria
della Misericordia, Udine, Italy;

· **SC Member and MAvERIC-Pilot Phase II Study Principal Investigator: Allen Luis, MBBS, PhD** – Co-Director of the Pericardial Diseases Clinic, Associate Professor of Medicine,
Department of Cardiovascular Medicine, at Mayo Clinic Rochester Minnesota;

· **SC Member and MAVERIC Phase III Trial Principal Investigator: Paul Cremer, MD** – Departments of Medicine and Radiology, Northwestern University,
and Multimodality Cardiac Imaging and Clinical Trials Unit, Bluhm Cardiovascular Institute;

· **SC Member: Antonio Abbate, MD, PhD** –
Ruth C. Heede Professor of Cardiology, School of Medicine, and Department of Medicine, Division of
Cardiovascular Medicine - Heart and Vascular Center, University of Virginia;

· **SC Member: Stephen Nicholls, MBBS, PhD** – Program Director, Victorian Heart Hospital, Director, Monash Victorian Heart Institute, and Professor of Cardiology,
Monash University, Melbourne ;

· **SC Member: Tom Kai Ming Wang, MBChB** –
Cardiologist, Section of Cardiovascular Imaging of the Tomsich Family Department of Cardiovascular Medicine, Sydell and Arnold Miller
Heart, Vascular and Thoracic Institute, Cleveland Clinic; and

· **SC Member: Mohamed M Al-Kazaz, MD –** Cardiologist, Assistant Professor of Medicine at the Feinberg School of Medicine, Northwestern University, and
 Section chief of general cardiology, at Bluhm Cardiovascular Institute, Northwestern.

· **SC Member: Dor Lotan, MD –** Assistant
 Professor of Medicine, Director Center for Pericardial Diseases, Columbia University Irving Medical Center.

***Recurrent Pericarditis – Phase II MAvERIC-Pilot Study (MAvERIC-Phase II)***

The completed MAvERIC-Phase II open label study enrolled 27 patients at eight prominent clinical centers in the U.S. specializing in pericardial disease care. The primary efficacy endpoint of the study is the change, from baseline to eight weeks, in patient-reported pericarditis pain using an 11-point numeric rating scale ("NRS"). The NRS is a validated clinical tool used across multiple conditions with acute and chronic pain, including previous studies of recurrent pericarditis. Secondary endpoints include the change in NRS pain score after 26 weeks of treatment, and changes in high sensitivity CRP. Importantly, the study assessed freedom from pericarditis recurrence.

In June 2024, the Corporation reported positive topline 8-week clinical data from its MAvERIC-Phase II study and in November 2024, the Corporation reported comprehensive MAvERIC-Phase II study results concurrent with the American Heart Association Scientific Sessions 2024. The data were included in an oral presentation as part of the Laennec Clinician-Educator Award & Lecture at the American Heart Association Scientific Sessions 2024. Dr. S. Allen Luis, Co-Director of the Pericardial Diseases Clinic and Associate Professor of Medicine in the Department of Cardiovascular Medicine at the Mayo Clinic, presented on behalf of the MAvERIC-Phase II investigators.

Baseline characteristics reflected a patient cohort with high disease burden. The average age of participants was 53 years, and 67% were female. The mean disease duration and the average number of pericarditis episodes per year prior to trial entry were 2.7 years and 5.8 events per year, respectively. The number of previous episodes of pericarditis was distributed as follows: 9 patients (33%) with 2 previous episodes; 9 (33%) with 3; 4 (15%) with 4; and 5 (19%) with more than four. Baseline pericarditis pain score averaged 5.8 on a 10-point scale, and the mean CRP level was 2.0 mg/dL. In addition to pericarditis chest pain, other manifestations of pericarditis-confirmed diagnosis were pericardial effusion in 21 patients (78%), pericardial rub in 4 (15%), and ST-segment elevation or PR depression in 5 (19%). Stable doses of baseline medications for recurrent pericarditis, in any combination, included colchicine (85% of patients), non-steroidal anti-inflammatory drugs (78%), and corticosteroids (41%). The 26-week study consisted of an 8-week treatment period ("TP") followed by an 18-week extension period ("EP"). In the first 10 days of the TP, CardiolRx™ was added to baseline medications for recurrent pericarditis and up titrated to 10 mg/kg twice daily, or the maximum tolerated dose. Throughout the TP, patients continued receiving this concomitant therapy but were weaned off baseline medications during the EP to assess pericarditis recurrence while on CardiolRx™ monotherapy.

Key results:

· Primary endpoint of patient-reported pericardial
pain on the 11-point NRS from 0-10 showed a mean reduction of 3.7, from 5.8 at baseline (range of 4 to 10) to 2.1 (range of 0 to 6) at
week 8. NRS is a validated instrument used to assess patient-reported pericarditis pain. Zero represents 'no pain at all',
whereas the upper limit of 10 represents 'the worst pain ever possible'.

· Median time to resolution or near resolution
of pain (defined as a score of <= 2) was rapid and was observed just 5 days following initiation of CardiolRx™ treatment.

· At week 8, 93% (25/27) of patients reported a
pain score reduction.

· Reduction in pain was maintained throughout the
duration of the trial with a mean reduction of 4.3, from 5.8 at baseline to 1.5 at week 26.

· CRP levels for the entire group of patients were
reduced from 2.0 mg/dL at baseline to 0.74 and 0.55 at weeks 8 and 26 respectively, with a median time to CRP normalization of 21 days.
CRP is a commonly used clinical marker of inflammation, and in combination with the NRS score, is used by clinicians to assess clinical
response and determine a recurrence.

· CRP normalized (<=0.5 mg/dL) at week 8 in
80% (8/10) of the patients with a baseline CRP of >=1 mg/dL, with a substantial mean reduction of 5.4 mg/dL being observed (5.7mg/dL
to 0.3 mg/dL).

· Freedom from recurrence was maintained in 71%
(17/24) of patients during the EP when CardiolRx™ was continued, and patients were weaned off baseline medications. For those patients
experiencing a recurrence the median time to an episode was 7.7 weeks during the EP.

· Number of pericarditis episodes per year was
markedly reduced from 5.8 prior to study to 0.9 during the study.

· CardiolRx™ was well tolerated with eighty-nine
percent of patients (24/27) progressing to the EP and overall study drug compliance reported at 95%.

In summary, marked, rapid, and durable reductions in both pericarditis pain and inflammation were observed in the MAvERIC-Phase II study and importantly these reductions were maintained throughout the 6-month study in a recurrent pericarditis population who presented with significant disease burden. In addition, CardiolRx™ substantially reduced the number of pericarditis episodes per year.

On the basis of the MAvERIC-Phase II study findings, Cardiol commenced patient enrollment in a pivotal Phase III clinical trial designed to definitively assess the impact of CardiolRx™ on pericarditis recurrence in a patient population at high risk for recurrence. See "Phase III Trial – Recurrent Pericarditis (MAVERIC)".

***Phase III Trial – Recurrent Pericarditis (MAVERIC)***

Cardiol's Phase III MAVERIC trial is designed to definitively assess the impact of CardiolRx™ on pericarditis recurrence. The randomized, double-blind, placebo-controlled study is expected to enroll approximately 110 patients at up to 25 clinical sites in the United States, Canada, and Europe. Completion of enrollment is anticipated in Q2 2026, with the potential to extend into Q3 2026 to accommodate patient enrollment from additional clinical sites.

MAVERIC is recruiting patients at high risk of recurrence following cessation of IL-1 blocker therapy, a setting associated with increased IL-1–driven disease recurrence. Should CardiolRx™ demonstrate a significant reduction in recurrence rates, the study will provide evidence that the drug favorably modulates the pro-inflammatory cytokine profile and may modify the disease.

The primary efficacy endpoint of the MAVERIC trial is the number of patients (percentage) free from a new episode of pericarditis recurrence at 24 weeks. Additional clinical endpoints include median time to new episode of pericarditis recurrence, percentage of days with no or minimal pain, and change in patient-reported pericarditis chest pain score and the inflammatory marker CRP.

IL-1 is a key pro-inflammatory cytokine in the pathophysiology of recurrent pericarditis. It is generated downstream following activation of the NLRP3 inflammasome and amplifies the autoinflammatory response characteristic of the disease. CardiolRx™ has been shown experimentally to inhibit the assembly and activation of the NLRP3 inflammasome and the subsequent generation of IL-1. Results from the MAvERIC-Phase II study demonstrated that treatment with CardiolRx™ led to marked reductions in pericarditis pain and recurrence episodes. These findings provide the rationale for undertaking the MAVERIC Phase III trial.

The Corporation has budgeted costs to complete this study to be approximately $6 million. If the MAVERIC trial meets its objectives, the details of next steps will be determined in consultation with regulatory agencies and the Corporation's external clinical advisors. Based on a successful end-of-Phase II meeting with the U.S. FDA and subject to MAVERIC outcomes, Cardiol believes the results from MAVERIC will support a New Drug Application. The Corporation may involve a pharmaceutical industry partner to fund commercialization of CardiolRx™ for the treatment of recurrent pericarditis.

***ARCHER PROGRAM IN ACUTE MYOCARDITIS***

Myocarditis is an acute inflammatory condition of the heart muscle (myocardium) characterized by chest pain, impaired cardiac function, atrial and ventricular arrhythmias, and conduction disturbances. Although the symptoms are often mild, myocarditis remains an important cause of acute and fulminant heart failure and is a leading cause of sudden cardiac death in people under 35 years of age. Although viral infection is the most common cause of myocarditis, the condition can also result from administration of therapies used to treat several common cancers, including chemo-therapeutic agents and immune checkpoint inhibitors<sup>3</sup>.

In a proportion of patients, the inflammation in the heart persists and causes decreased heart function with symptoms and signs of heart failure, and as such pharmacological treatment is based on conventional therapy for heart failure. This includes diuretics, ACE inhibitors, angiotensin receptors blockers, beta blockers, and aldosterone inhibitors. For those with a fulminant presentation, intensive care is often required, with the use of inotropic medications (to increase the force of the heart muscle contraction). Severe cases frequently require ventricular assist devices or extracorporeal oxygenation and may necessitate heart transplantation. There are no U.S. FDA-approved therapies for acute myocarditis. Patients hospitalized with acute myocarditis experience an average 7-day length of stay and a 4 – 6% risk of in-hospital mortality, with average hospital charge per stay estimated at U.S.$110,000 in the U.S.<sup>3</sup>.

Data from multiple sources, including the 'Global Burden of Disease Study', reports that the number of cases of myocarditis per year range from approximately 10 to 22/100,000 persons (estimated U.S. patient population of 33,000 to 73,000), qualifying the condition as a rare disease in the U.S. and in European Union. Cardiol believes that there is a significant opportunity to develop a therapy for acute myocarditis that may be eligible for designation as an orphan drug under the U.S. FDA's Orphan Drug Designation and the European Medicines Agency Orphan Medicine programs<sup>3</sup>.

The Corporation's Phase II ARCHER trial (ARCHER) was designed in collaboration with an independent steering committee comprising distinguished thought leaders in heart failure and myocarditis from international centers of excellence. The primary endpoints of the trial, which were evaluated after 12 weeks of double-blind therapy, consist of the following CMR measures: myocardial edema/fibrosis (extra-cellular volume) and left ventricular ("LV") function (global longitudinal strain). Additional CMR measures of interest include change in LV mass.

The ARCHER Steering Committee comprised distinguished thought leaders in heart failure and myocarditis from international centers of excellence who contributed to the design and execution of the ARCHER trial.

· **Chair: Dennis M. McNamara, MD** –
Professor of Medicine at the University of Pittsburgh, Director of the Center for Heart Failure Research at the University of Pittsburgh
Medical Center;

· **Co-Chair: Leslie T. Cooper, Jr., MD** –
General cardiologist and the Elizabeth C. Lane, Ph.D. and M. Nadine Zimmerman, Ph.D. Professor of Internal Medicine, Mayo Clinic, Jacksonville,
FL;

· **Arvind Bhimaraj, MD** – Specialist
in Heart Failure and Transplantation Cardiology and Associate Professor of Cardiology, DeBakey Heart & Vascular Center and J.C.
Walter Jr. Transplant Center, Houston Methodist Hospital;

· **Wai Hong Wilson Tang, MD** – Advanced
Heart Failure and Transplant Cardiology specialist at the Cleveland Clinic in Cleveland, Ohio. Dr. Tang is also the Director of the
Cleveland Clinic's Center for Clinical Genomics; Research Director, and staff cardiologist in the Section of Heart Failure and Cardiac
Transplantation Medicine in the Sydell and Arnold Miller Family Heart & Vascular Institute at the Cleveland Clinic;

· **Peter Liu, MD** – Chief Scientific
Officer and Vice President, Research, of the University of Ottawa Heart Institute, and Professor of Medicine and Physiology at the University
of Toronto and University of Ottawa;

· **Carsten Tschöpe, MD** – Clinical
Professor in Cardiology, Head of the Cardiomyopathy Unit, Department of Cardiology, Angiology and Intensive Care, Campus Virchow, German
Heart Center (DHZC) at Charité, Berlin;

· **Matthias Friedrich, MD** – Full Professor
within the Departments of Medicine and Diagnostic Radiology at McGill University in Montreal, and Chief, Cardiovascular Imaging at the
McGill University Health Centre;

· **Yaron Arbel, MD** – Cardiologist and
Director of the CardioVascular Research Center (CVRC) at the Tel Aviv "Sourasky" Medical Center;

· **Edimar Bocchi, MD** – Serves as the
Head of Heart Failure Clinics and Heart Failure Team at Heart Institute (Incor) of Hospital das Clinicas of São Paulo University
Medical School, Associate Professor of São University Medical School, São Paulo, Brazil; and

· **Mathieu Kerneis, MD, PhD** – Interventional
cardiologist at Pitié Salpêtrière Hospital (Sorbonne University), and ACTION Study Group Investigator.

In August 2025, the Corporation announced topline results from the ARCHER trial, which completed with 109 enrolled patients at leading cardiovascular research centers in the United States, France, Brazil, and Israel.

In the two primary endpoints, extracellular volume ("ECV") and global longitudinal strain ("GLS"), CardiolRx™ showed a notable improvement in ECV (p = 0.0538) compared to placebo following 12 weeks of double-blind therapy. No significant difference was observed in GLS in a population that had predominantly preserved left ventricular function at baseline. The reduction in ECV was associated with improvements over placebo in multiple pre-specified CMR endpoints, including a significant reduction in LV mass.

The ARCHER trial results provide compelling clinical proof of concept for CardiolRx™ and support advancing the clinical development of CardiolRx™ and CRD-38 in cardiomyopathies, heart failure, and myocarditis. Consistent with findings from Cardiol's MAvERIC-Phase II trial in recurrent pericarditis, CardiolRx™ was shown to be safe and well tolerated. The ARCHER results were presented in an oral session at the Annual Meeting of the European Society of Cardiology (ESC) Working Group on Myocardial & Pericardial Disease (M&PD) in Trieste, Italy, on November 29, 2025, and subsequently published in a February 2026 issue of the journal *ESC Heart Failure*.

The Corporation is reviewing the full ARCHER results with key opinion leaders in myocarditis and heart failure, regulatory agencies, and representatives from the pharmaceutical industry to determine next steps. Following these discussions, the Corporation will provide an update regarding the timeline for completing potential additional clinical development programs based on the ARCHER data, as well as associated costs—all of which will depend on a variety of factors. The Corporation also may involve a pharmaceutical industry partner to support additional clinical development and commercialization of CardiolRx™ and CRD-38 for the treatment of myocarditis, and other inflammatory cardiac conditions including heart failure.

***CRD-38 PROGRAM FOR TREATMENT OF HEART DISEASE***

Cardiol is developing CRD-38, a novel subcutaneously administered cannabidiol formulation intended for the treatment of heart failure and other inflammatory cardiac conditions. In pre-clinical studies, this novel therapy demonstrated cardioprotective effects, including improvements in cardiac function and reductions in cardiac hypertrophy, fibrosis, and inflammation. The Corporation is currently conducting formulation optimization studies and Investigational New Drug ("IND")-enabling studies necessary to support a future IND application with the U.S. FDA to initiate first-in-human Phase I clinical studies. The Corporation has budgeted approximately $2 million to complete these IND-enabling studies, which are underway and are currently anticipated to be completed by the end of 2026.

If Cardiol determines that the IND-enabling studies meet its objectives, next steps related to the clinical development of CRD-38 will be assessed in consultation with external clinical advisors and regulatory agencies. The total cost and timeline to complete this clinical development program cannot be determined at this stage as this will depend on a variety of factors. The Corporation may involve a commercial partner from the pharmaceutical industry to fund the clinical development and commercialization of CRD-38.

***Scientific Advisory Board***

The Corporation has established a Scientific Advisory Board comprised of distinguished thought leaders in cardiovascular medicine. These individuals will lend their expertise in cardiovascular research and provide invaluable guidance to the Corporation's research and clinical programs. The Scientific Advisory Board members include:

<u>Paul M. Ridker, MD, MPH</u>

Dr. Paul Ridker is Director of the Center for Cardiovascular Disease Prevention at Brigham and Women's Hospital in Boston, where he leads a major translational research program focused mainly on inflammation in atherosclerotic cardiovascular disease. He is the Eugene Braunwald Professor of Medicine at Harvard Medical School and Professor of Epidemiology at the Harvard T.H. Chan School of Public Health.

Dr. Ridker received his medical degree from Harvard School of Medicine and completed an internal medicine residency and a cardiology fellowship at Brigham and Women's Hospital. Dr. Ridker is board certified in internal medicine. His clinical interests include coronary artery disease and the prevention of atherosclerotic events in high risk populations. Internationally recognized for defining the role of inflammation in atherothrombosis, Dr. Ridker's primary research has focused on inflammatory mediators of heart disease, biomarkers such as high sensitivity C reactive protein, and the molecular and genetic epidemiology. He has served as Principal Investigator or Study Chair for multiple large, international randomized trials demonstrating that targeting vascular inflammation can reduce major adverse cardiovascular events, thereby directly informing the development of novel anti-inflammatory strategies for the prevention and treatment of coronary disease.

Dr. Ridker is the author of over 900 original reports plus 150 reviews and book chapters, and six textbooks related to cardiovascular medicine. He has a long tenure of serving on the Board of External Experts for the National Heart Lung and Blood Institute (NHLBI), as well as on multiple US FDA review panels and has delivered many invited lectures worldwide.

His contributions to cardiovascular prevention and inflammation biology have been recognized with numerous honors, exemplified by his inclusion in TIME magazine's list of 100 most influential people of 2004, ranking among the ten most cited cardiovascular researchers worldwide between 2000 and 2010, the American Heart Association Distinguished Scientist Award (2013), the Braunwald Lecture of the American College of Cardiology (2019), the Gotto Prize for Atherosclerosis Research from the International Atherosclerosis Society (2021), and election to the National Academy of Medicine (USA).

<u>Bruce McManus, PhD, MD</u>

Dr. McManus is Professor Emeritus, Department of Pathology and Laboratory Medicine at the University of British Columbia and an internationally recognized leader in inflammatory heart disease with a particular focus on viral myocarditis and heart failure. His academic and leadership roles have spanned CEO of the Centre of Excellence for Prevention of Organ Failure (PROOF Centre), Director of the UBC Centre for Heart Lung Innovation, the inaugural Director of the Providence Heart and Lung Institute at St. Paul's Hospital, Co-Director of the community-wide Institute for Heart and Lung Health, and inaugural Scientific Director of the Institute of Circulatory and Respiratory Health at the Canadian Institutes of Health Research.

Dr. McManus's investigative work relates to mechanisms, consequences, and detection of myocardial injury and aberrant repair in inflammatory diseases of the heart and blood vessels, informing contemporary approaches to the diagnosis and management of acute viral myocarditis and its progression to heart failure. His life's scholarship includes more than 450 peer-reviewed publications, over 60 invited chapters, and several books, and he has trained a generation of clinicians and scientists who are advancing novel therapies for inflammatory cardiomyopathies.

Dr. McManus holds BA and MD degrees from the University of Saskatchewan, an MSc from Pennsylvania State University, and a PhD from the University of Toledo. He completed post-doctoral fellowships in Environmental Physiology at the University of California, Santa Barbara and Cardiovascular & Pulmonary Pathology at the National Heart, Lung, and Blood Institute in Bethesda, as well as residency training in Internal Medicine and Pathology at the Peter Bent Brigham Hospital, Harvard University. Prior to his appointment at the University of British Columbia, Dr. McManus served on the faculty of the University of Nebraska Medical Center for eleven years.

Dr. McManus has been widely honored for his scientific and mentoring contributions, including the prestigious Max Planck Research Award, the Distinguished Achievement Award by the Society for Cardiovascular Pathology, the Howard Morgan Award from the International Academy of Cardiovascular Sciences, and the Lifetime Achievement Award from Canadian Blood Services. He is a Fellow of the Royal Society of Canada and has been appointed to both the Order of Canada and the Order of British Columbia.

<u>Joseph A. Hill, MD, PhD</u>

Dr. Hill is Professor of Internal Medicine and Molecular Biology at UT Southwestern Medical Center in Dallas, TX, and Director of the Harry S. Moss Heart Center. He served as Chief of Cardiology at UT Southwestern for 21 years prior to stepping down in 2023.

Dr. Hill holds the James T. Willerson, MD, Distinguished Chair in Cardiovascular Diseases, and the Frank M. Ryburn Jr. Chair in Heart Research. His research focuses on molecular mechanisms of structural, functional, metabolic, and electrophysiological remodeling in cardiac hypertrophy and heart failure, with direct relevance to developing novel therapies for inflammatory and fibrotic heart disease.

After graduating from Duke University with MD and PhD degrees in 1987, Dr. Hill completed a five-year postdoctoral fellowship in molecular neurobiology at the Institut Pasteur in Paris, studying central and peripheral nicotinic receptors. Subsequently, he completed an internal medicine internship and residency, as well as a clinical cardiology fellowship, at the Brigham and Women's Hospital, Harvard Medical School.

After serving on the faculty at the University of Iowa for five years, Dr. Hill joined UT Southwestern in 2002 as Chief of Cardiology, where he has built a translational research program aimed at elucidating pathways that drive adverse cardiac remodeling and heart failure progression. His work has helped identify molecular targets with potential to modulate inflammation, fibrosis, and cardiomyocyte survival, supporting the development of next-generation cardioprotective therapies.

In addition to publishing nearly 280 scholarly articles, Dr. Hill has co-edited a major textbook and has contributed chapters to 14 books. He has served on many NIH panels and committees and delivered numerous invited lectures worldwide. His contributions have been recognized with multiple honors, including the 2018 Research Achievement Award from the International Society for Heart Research, the 2019 Louis and Artur Lucian Award from McGill University, the 2023 Medal of Merit from the International Academy of Cardiovascular Sciences, the 2025 Gill Heart and Vascular Institute Award for Outstanding Contributions to Cardiovascular Research, and the 2025 Bohuslav Ostadal Award for Excellence in Cardiovascular Sciences from the International Academy of Cardiovascular Sciences.

Dr. Hill has served on the editorial boards and as a reviewer for leading journals, including the *Journal of the American Medical Association, Circulation, Circulation Research, American Journal of Cardiology, and Proceedings of the National Academy of Sciences of the USA.* For the past 10 years, he has served as the Editor-in-Chief of the esteemed American Heart Association journal *Circulation*.

**Outlook**

Within the next 12 – 18 months, the Corporation expects to achieve the following:

· Complete the pivotal Phase III MAVERIC trial evaluating the impact of CardiolRx™
on pericarditis recurrence and report results;

· Advance business development discussions with prospective strategic partners;

· Based on ARCHER results, evaluate options for further clinical development
of CardiolRx™ to address additional orphan inflammatory cardiac indications; and

· Subject to the outcomes of the IND-enabling studies, initiate the clinical
development of CRD-38.

The Corporation expects that the March 31, 2026, cash and cash equivalents of $27.7 million will be sufficient to fund operations and capital requirements associated with achieving these corporation milestones, into Q4, 2027.

**Use of Offering Proceeds**

As disclosed in the Corporation's prospectus dated October 9, 2024 (the "October 2024 Offering"), the Corporation intends to use the net proceeds of the October 2024 Offering to support the clinical development of CardiolRx™ for the treatment of recurrent pericarditis and for general and administrative expenses, working capital, and other expenses. The Corporation may reallocate the net offering proceeds that it obtained from time to time depending upon our growth strategy relative to market and other conditions in effect at the time. Until we expend the net offering proceeds, we will hold them in cash and/or invest them in short-term, interest bearing, and investment-grade securities. As of March 31, 2026, $7.8M of the October 2024 Offering proceeds have been used for the clinical development of CardiolRx™ for the treatment of recurrent pericarditis.

A comparison between the projected Use of Available Funds, as defined and disclosed in the LIFE Offering Document dated January 16, 2026, and spending from January 1, 2026 to March 31, 2026 is as follows:

---

| | | |
|:---|:---|:---|
|  | **Amount** | **Spent** |
| Complete Phase III MAVERIC trial in recurrent pericarditis with CardiolRx™ | 10000000 | 2300000 |
| Advance the development of CRD-38 into a clinical program | 3400000 | 800000 |
| Complete Phase 1 study with CRD-38 | 3000000 | nil |
| General and administrative expenses, working capital and other research and development expenses | 17459000 | 6600000 |

---

**Summary of Quarterly Results**

The Corporation's quarterly information in the table below is prepared in accordance with IFRS Accounting Standards.

---

| | | | |
|:---|:---|:---|:---|
| | **Profit or (Loss)** | **Profit or (Loss)** | |
| <br>**Three Months Ended** | **Total ($)** | **Per Share<sup>(9)</sup><br> ($)** | **Total**<br>**Assets<br> ($)** |
| March 31, 2026<sup>(1)</sup> nil | (10818589) | (0.10) | 31406607 |
| December 31, 2025<sup>(2)</sup> nil | (7212569) | (0.07) | 23619933 |
| September 30, 2025<sup>(3)</sup> nil | (9964281) | (0.12) | 12947801 |
| June 30, 2025<sup>(4)</sup> nil | (8354371) | (0.10) | 19937699 |
| March 31, 2025<sup>(5)</sup> nil | (8287653) | (0.10) | 25454895 |
| December 31, 2024<sup>(6)</sup> nil | (8178310) | (0.10) | 31863751 |
| September 30, 2024<sup>(7)</sup> nil | (12728484) | (0.18) | 17519645 |
| June 30, 2024<sup>(8)</sup> nil | (6590873) | (0.10) | 26312660 |

---

Notes:

1. Net loss of $10,818,589 included general and administration of $4,757,383, research and development of $4,949,411, and change in derivative liability of $1,529,519.
These are partially offset by gain on foreign exchange of $217,000 and interest income of $200,724.

2. Net loss of $7,212,569 included general and administration of $5,288,185 and research and development of $2,742,790 and loss on foreign exchange of $308,546. These
are partially offset by interest income of $175,209 and change in derivative liability of $951,743.

3. Net loss of $9,964,281 included general and administration of $5,393,522 and research and development of $4,786,578. These are partially offset by interest income
of $122,256 and gain on foreign exchange of $93,563.

4. Net loss of $8,354,371 included general and administration of $4,944,477, research and development of $2,731,681, and loss on foreign exchange of $858,880. These
are partially offset by interest income of $180,667.

5. Net loss of $8,287,653 included general and administration of $4,671,651, research and development of $3,757,412, and loss on foreign exchange of $106,859. These
are partially offset by interest income of $248,269.

&nbsp;&nbsp;&nbsp;&nbsp;6. Net loss of $8,178,310 included general and administration of $5,760,555, and research and development
 of $4,228,869. These are partially offset by interest
income of $306,775, and gain on foreign exchange of $1,500,692.

7. Net loss of $12,728,484 included general and administration of $10,389,712, research and development of $3,750,688, and loss on foreign exchange of $142,033. These
are partially offset by a change in derivative liability of $1,352,085, and interest income of $201,864.

8. Net loss of $6,590,873 included general and administration of $5,031,702, and research and development of $2,709,644. These are partially offset by a change in derivative
liability of $691,047, a gain on foreign exchange of $152,017, and interest income of $307,409.

9. Basic and fully diluted.

**Discussion of Operations**

**Three months ended March 31, 2026, compared to the three months ended March 31, 2025**

For the three months ended March 31, 2026, the Corporation's net loss was $10,818,589, compared to a net loss of $8,287,653 for the three months ended March 31, 2025. The increase in net loss of $2,530,936 is a result of the following:

· General and administration expenses slightly
increased to $4,757,383 for the three months ended March 31, 2026, compared to $4,671,651 for the three months ended March 31,
2025. The increase was primarily due to an increase in salaries and benefits, partially offset by a decrease in corporate communications,
marketing, and investor relations, and administration expenses.

· Research and development increased to $4,949,411
for the three months ended March 31, 2026, compared to $3,757,412 for the three months
ended March 31, 2025. During the three months ended March 31, 2026, the Corporation incurred research and development
costs related to basic science, pre-clinical studies, and clinical studies, specifically relating to the ARCHER, MAVERIC, and CRD-38
programs, in the amount of $69,991, $2,279,433, and $824,703, respectively. This compares to $932,910, $954,295, and $195,159,
respectively, relating to the ARCHER, MAVERIC, and CRD-38 programs for the three months ended March 31, 2025.

· During the three months ended March 31,
2026, there was a loss on the change in derivative liability of $1,529,519. There was no gain or loss on change in derivative liability
for the three months ended March 31, 2025.

· A gain on foreign exchange is included in the
net loss for the three months ended March 31, 2026, of $217,000, compared to a loss on foreign exchange during the three months ended
March 31, 2025, of $106,859. This is mainly the result of the revaluation of funds held in USD.

**Capital Management**

The Corporation manages its capital to ensure sufficient financial flexibility to achieve the ongoing business objectives including research activities, funding of future growth opportunities, and pursuit of acquisitions.

The Corporation monitors its capital structure and makes adjustments according to market conditions in an effort to meet its objectives given the current outlook of the business and industry in general. The Corporation may manage its capital structure by issuing new shares, repurchasing outstanding shares, adjusting capital spending, or disposing of assets. The capital structure is reviewed by Management and the Board of Directors on an ongoing basis.

The Corporation considers its capital to be total equity, comprising share capital, contributed surplus, and warrants, less accumulated deficit, which at March 31, 2026, totaled $24,203,305 (December 31, 2025 – $17,877,718).

The Corporation manages capital through its financial and operational forecasting processes. The Corporation reviews its working capital and forecasts its future cash flows based on operating expenditures, and other investing and financing activities. The forecast is updated based on activities related to its research programs and reviewed with the Board of Directors of the Corporation.

The Corporation is not currently subject to any capital requirements imposed by a lending institution or regulatory body.

The Corporation expects that its capital resources will be sufficient to discharge its liabilities as of the current statement of financial position date.

**Off-Balance Sheet Arrangements**

As of the date of this MD&A, the Corporation does not have any off-balance sheet arrangements that have, or are reasonably likely to have, a current or future effect on the results of operations or financial condition of the Corporation, including, and without limitation, such considerations as liquidity and capital resources.

**Liquidity and Capital Resources**

At March 31, 2026, Cardiol had $27,673,191 in cash and cash equivalents (December 31, 2025 – $21,416,684).

At March 31, 2026, accounts payable and accrued liabilities were $3,419,508 (December 31, 2025 – $3,478,825). The Corporation's cash and cash equivalents balances as at March 31, 2026, and December 31, 2025, are sufficient to pay these liabilities.

The Corporation currently has no operating revenues and therefore must utilize its funds from financing transactions to maintain its capacity to meet ongoing operating activities. Future financing may come from product sales, licensing arrangements, research and commercial development partnerships, government grants, and/or corporate finance arrangements.

We expect to continue to incur substantial losses as we continue our research and development efforts. We continue to manage our research and development plan to ensure optimal use of our existing resources as we expect to fund our operations and capital requirements, associated with achieving our corporate milestones, with existing working capital (See "Outlook"). We expect to continue to incur additional costs associated with operating as a public company. Factors that may affect our anticipated cash usage, but are not limited to, expansion of our clinical trial programs, the timing of patient enrollment in our clinical trials, the actual costs incurred to support each clinical trial, the number of treatments each patient will receive, the timing of research and development activity with our clinical trial research collaborations, and other factors described in the "Risk Factors" section.

As of March 31, 2026, December 31, 2025, and to the date of this MD&A, the cash resources of Cardiol are held with one Canadian chartered bank. The Corporation has no variable interest rate debt, and its credit and interest rate risk are minimal. Accounts payable and accrued liabilities are short-term and non-interest bearing.

<u>For the 2026 Fiscal Period</u>

Cash and cash equivalents used in operating activities were $7,517,631 for the three months ended March 31, 2026. Operating activities were affected by a net loss of $10,818,589, partially offset by the net change in non-cash working capital balances of $119,107, and other non-cash adjustments of $3,181,851. Non-cash adjustments mainly consisted of $1,842,835 for share-based compensation and $1,529,519 for loss on change in derivative liability.

Cash and cash equivalents used in investing activities were $47,585 for the three months ended March 31, 2026, as a result of the purchase of property and equipment.

Cash and cash equivalents provided by financing activities were $13,599,782 for the three months ended March 31, 2026, as a result of the proceeds from financing, partially offset by payment of lease liability.

<u>Use of Working Capital</u>

As of March 31, 2026, Cardiol's cash and cash equivalents were $27,673,191 and working capital was $24,140,952 ($27,808,338 excluding the non-cash derivative liability). Based on current projections, Cardiol believes that this amount is sufficient to fund operations and capital requirements, associated with achieving corporate milestones into Q4 2027, as described in the "Outlook" section above.

The Corporation has material commitments and obligations for cash resources set out below. The Corporation has no commitments for capital expenditures.

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| **Contractual Obligations** | **Total<br> ($)** | **Up to 1 year<br> ($)** | **1 – 3 years<br> ($)** | **4 – 5 years<br> ($)** | **After 5 years<br> ($)** |
| &nbsp;&nbsp;&nbsp;Amounts payable and other liabilities | 3419508 | 3419508 | Nil | Nil | Nil |
| &nbsp;&nbsp;&nbsp;Office lease<sup>(1)</sup> | 276990 | 107222 | 169768 | Nil | Nil |
| &nbsp;&nbsp;&nbsp;Consulting agreements | 245912 | 232000 | 13912 | Nil | Nil |
| &nbsp;&nbsp;&nbsp;Contract research | 1711421 | 1148563 | 540662 | 22196 | Nil |
| **Total** | **5653831** | **4907293** | **724342** | **22196** | **Nil** |

---

Note:

(1) The Corporation has leased premises from third parties.

**Related Party Transactions**

a) Key Management personnel are those persons having authority and responsibility for planning, directing,
and controlling the activities of the Corporation directly or indirectly, including any Directors (executive and non-executive) of the
Corporation. Remuneration of directors and key management personnel was as follows:

---

| | | |
|:---|:---|:---|
|  | **Three months ended<br> March 31, 2026** | **Three months ended<br> March 31, 2025** |
| Salaries and benefits | $1301084 | $1305013 |
| Share-based payments | 403563 | 468960 |
|  | $**1704647** | $**1773973** |

---

As at March 31, 2026, $76,154 (December 31, 2025 - $nil) was owed to directors and key management personnel.

**Critical Accounting Judgments, Estimates, and Assumptions**

The preparation of the Financial Statements requires Management to make certain estimates, judgments, and assumptions that affect the reported amounts of assets and liabilities at the date of the Financial Statements and reported amounts of expenses during the reporting period. Actual outcomes could differ from these estimates. The Financial Statements include estimates that, by their nature, are uncertain. The impacts of such estimates are pervasive throughout the Financial Statements and may require accounting adjustments based on future occurrences. Revisions to accounting estimates are recognized in the period in which the estimate is revised and future periods if the revision affects both current and future periods. These estimates are based on historical experience, current and future economic conditions, and other factors, including expectations of future events that are believed to be reasonable under the circumstances.

**Critical accounting estimates**

Significant assumptions about the future that Management has made that could result in a material adjustment to the carrying amounts of assets and liabilities, in the event that actual results differ from assumptions made, relate to, but are not limited to, the following:

· the valuation of performance share units;

· the valuation of the derivative liability;

· the estimate of the percentage of completion of certain research and development
agreements; and

· the valuation of income tax accounts.

**Critical accounting judgments**

· Management applied judgment in determining the
functional currency of the Corporation as Canadian dollars;

· Management applied judgment in determining whether
performance conditions on share-based awards were market or non-market, and whether the fair value of the goods or services provided by
certain non-employees could be reliably measured; and

· Management applied judgment in determining the
Corporation's ability to continue as a going concern. The Corporation has incurred significant
losses since its inception. Management determined that a material going concern uncertainty does not exist due to the sufficient working
capital to support their planned expenditure levels. Future financing may come from product sales, licensing arrangements, research and
commercial development partnerships, government grants, and/or corporate finance arrangements.

**Future Accounting Policies**

&nbsp;&nbsp;&nbsp;&nbsp;(i) IFRS 18 - Presentation and disclosure in financial statements

In April 2024, the IASB issued IFRS 18, focusing on presentation and disclosure in financial statements. Key changes would impact the structure of the consolidated statement of loss and comprehensive loss and amendments to disclosure requirements for certain profit or loss performance measures. IFRS 18 will replace IAS 1, effective reporting period beginning on January 1, 2027. This will also impact comparative information at the point of adoption.

An assessment of the applicability of the new standard will be performed on the consolidated financial statements to which the pronouncement applies.

**Share Capital**

Other than as described below, as of the date of this MD&A, there are no equity or voting securities of the Corporation outstanding, and no securities convertible into, or exercisable or exchangeable for, voting or equity securities of the Corporation.

As of the date of this MD&A, the outstanding capital of the Corporation includes 115,272,240 issued and outstanding common shares; 400,000 common shares issuable to Dalton Chemical Laboratories, Inc. operating as Dalton ("Dalton"), if Dalton meets certain performance objectives, and stock options, warrants, performance share units, and restricted share units as shown below:

<u>Stock Options</u>

---

| | | | |
|:---|:---|:---|:---|
| **Expiry date** | **Exercise<br> price ($)** | **Options<br> outstanding** | **Options<br> exercisable** |
| December 8, 2026 | 3.59 | 325000 | 325000 |
| January 11, 2027 | 2.18 | 220000 | 220000 |
| March 1, 2027 | 2.56 | 200000 | 200000 |
| March 9, 2027 | 1.13<sup>(1)</sup> | 200000 | 200000 |
| May 12, 2027 | 1.46 | 70000 | 70000 |
| September 13, 2027 | 1.61 | 207500 | 207500 |
| July 21, 2028 | 1.67 | 50000 | 37500 |
| July 7, 2029 | 2.07 | 30000 | 10000 |
| August 19, 2029 | 1.50 | 30000 | 10000 |
| May 25, 2030 | 1.09<sup>(1)</sup> | 120000 | 90000 |
| May 25, 2030 | 2.12 | 100000 | 75000 |
| May 29, 2030 | 1.16<sup>(1)</sup> | 60000 |  |
| December 2, 2030 | 1.40 | 2620000 |  |
| December 2, 2030 | 1.00<sup>(1)</sup> | 490000 | - |
| **Total** |  | **4722500** | **1445000** |

---

(1) Exercise price denoted in USD.

<u>Warrants</u>

---

| | | |
|:---|:---|:---|
| **Expiry date** | **Exercise<br> price ($)** | **Warrants<br> outstanding** |
| October 17, 2027 | 1.35<sup>(1)</sup> | 3627500 |
| October 20, 2027 | 1.35<sup>(1)</sup> | 735000 |
| January 23, 2028 | 1.75 | 5711539 |
| **Total** |  | **10074039** |

---

(1) Exercise price denoted in USD.

<u>Performance Share Units</u>

The Corporation has 313,625 outstanding performance share units ("PSUs") subject to vesting conditions specific to each grant. Of the outstanding PSUs, none have fully vested as of the date of this MD&A.

<u>Restricted Share Units</u>

The Corporation has 4,750,943 outstanding restricted share units ("RSUs") subject to vesting conditions specific to each grant. Of the outstanding RSUs, 2,749,684 have fully vested as of the date of this MD&A.

**Financial Instruments**

**Recognition**

The Corporation recognizes a financial asset or financial liability on the statement of financial position when it becomes party to the contractual provisions of the financial instrument. Financial assets are initially measured at fair value and are derecognized either when the Corporation has transferred substantially all the risks and rewards of ownership of the financial asset, or when cash flows expire. Financial liabilities are initially measured at fair value and are derecognized when the obligation specified in the contract is discharged, cancelled, or expired.

A write-off of a financial asset (or a portion thereof) constitutes a derecognition event. A write-off occurs when the Corporation has no reasonable expectations of recovering the contractual cash flows on a financial asset.

**Classification and Measurement**

The Corporation determines the classification of its financial instruments at initial recognition. Financial assets and financial liabilities are classified according to the following measurement categories:

· those to be measured subsequently at fair value, either through profit or
loss ("FVTPL") or through other comprehensive income ("FVTOCI"); and,

· those to be measured subsequently at amortized cost.

The classification and measurement of financial assets after initial recognition at fair value depends on the business model for managing the financial asset and the contractual terms of the cash flows. Financial assets that are held within a business model whose objective is to collect the contractual cash flows, and that have contractual cash flows that are solely payments of principal and interest on the principal outstanding, are generally measured at amortized cost at each subsequent reporting period. All other financial assets are measured at their fair values at each subsequent reporting period, with any changes recorded through profit or loss or through other comprehensive income (which designation is made as an irrevocable election at the time of recognition).

After initial recognition at fair value, financial liabilities are classified and measured at either:

· amortized cost;

· FVTPL, if the Corporation has made an irrevocable election at the time of
recognition, or when required (for items such as instruments held for trading or derivatives); or,

· FVTOCI, when the change in fair value is attributable to changes in the Corporation's
credit risk.

The Corporation reclassifies financial assets when and only when its business model for managing those assets changes. Financial liabilities are not reclassified.

Transaction costs that are directly attributable to the acquisition or issuance of a financial asset or financial liability classified as subsequently measured at amortized cost are included in the fair value of the instrument on initial recognition. Transaction costs for financial assets and financial liabilities classified at fair value through profit or loss are expensed in profit or loss.

The Corporation's financial assets consist of cash and cash equivalents and accounts receivable, which are classified and measured at amortized cost. The Corporation's financial liabilities consist of accounts payable and accrued liabilities, and lease liability, which are classified and measured at amortized cost, and derivative liabilities which are classified and measured at FVTPL.

<u>Impairment</u>

The Corporation assesses all information available, including on a forward-looking basis the expected credit losses associated with any financial assets carried at amortized cost. The impairment methodology applied depends on whether there has been a significant increase in credit risk. To assess whether there is a significant increase in credit risk, the Corporation compares the risk of a default occurring on the asset as at the reporting date with the risk of default as at the date of initial recognition based on all information available, and reasonable and supportive forward-looking information.

**Fair Value**

The Corporation provides information about its financial instruments measured at fair value at one of three levels according to the relative reliability of the inputs used to estimate the fair value. The hierarchy gives the highest priority to unadjusted quoted prices in active markets for identical assets or liabilities and the lowest priority to unobservable inputs. The three levels of the fair value hierarchy are as follows:

· Level 1: quoted prices (unadjusted) in active markets for identical assets or liabilities;

· Level 2: inputs other than quotes prices included in Level 1 that are observable for
the asset or liability, either directly (i.e., as prices) or indirectly (i.e., derived from prices); and

· Level 3: inputs for the asset or liability that are not based on observable market data
(unobservable inputs).

The Corporation's derivative liabilities were measured at fair value Level 3. The fair value of all other financial instruments approximates their carrying amounts due to the relatively short period to maturity.

**Financial Instrument Risks**

The Corporation's activities expose it to a variety of financial risks: credit risk, liquidity risk, and market risk (including interest rate and foreign currency risk). These financial risks are in addition to the risks set out under "Risk Factors".

Risk management is carried out by the Corporation's Management team under policies approved by the Board of Directors. The Board of Directors also provides regular guidance for overall risk management.

There were no changes to credit risk, liquidity risk, or market risk for the 2025 Fiscal Period.

**Credit risk**

Credit risk is the risk that one party to a financial instrument will cause a financial loss for the other party by failing to discharge an obligation. The Corporation's financial instruments that are exposed to concentrations of credit risk relate primarily to cash and cash equivalents and accounts receivable.

The Corporation mitigates its risk by maintaining its funds with large reputable financial institutions, from which Management believes the risk of loss to be minimal. Interest receivable relates to guaranteed investment certificates and cash balances held with large reputable financial institutions as well as receivables. The Corporation's Management considers that all the above financial assets are of good credit quality.

**Liquidity risk**

Liquidity risk is the risk that the Corporation encounters difficulty in meeting its obligations associated with financial liabilities. Liquidity risk includes the risk that, as a result of operational liquidity requirements, the Corporation will not have sufficient funds to settle a transaction on the due date; will be forced to sell financial assets at a value which is less than what they are worth; or may be unable to settle or recover a financial asset. Liquidity risk arises from accounts payable and accrued liabilities and commitments. The Corporation limits its exposure to this risk by closely monitoring its cash flow.

**Market risk**

Market risk is the risk of loss that may arise from changes in market factors, such as interest rates and foreign exchange rates.

**(a)** **Interest rate risk** 

The Corporation currently does not have any short-term or long-term debt that is variable interest bearing and, as such, the Corporation's current exposure to interest rate risk is minimal.

**(b)** **Foreign currency risk** 

Foreign exchange risk is the risk that the fair value or future cash flows of a financial instrument will fluctuate because of changes in the foreign exchange rates. The Corporation enters into foreign currency purchase transactions and has assets that are denominated in foreign currencies and thus is exposed to the financial risk of earnings fluctuations arising from changes in foreign exchange rates and the degree of volatility of these rates. The Corporation does not currently use derivative instruments to reduce its exposure to foreign currency risk.

The Corporation holds balances in U.S. dollars which could give rise to exposure to foreign exchange risk. Sensitivity to a plus or minus 10% change in the foreign exchange rate of the U.S. dollar against the Canadian dollar would affect the reported loss and comprehensive loss by approximately $1,185,000 (December 31, 2025 – $1,445,000).

**Commitments and Contingency**

(i) The Corporation has leased premises from third parties. The minimum committed lease payments as at March 31, 2026, which include the lease liability payments, are as follows:

---

| | |
|:---|:---|
| **Fiscal year** | |
| 2026 | $80416 |
| 2027 | 107222 |
| 2028 | 89352 |
| **Total** | $**276990** |

---

(ii) The Corporation has signed various agreements with consultants to provide services. Under the agreements, the Corporation has the following remaining commitments.

---

| | |
|:---|:---|
| **Fiscal year** | |
| 2026 | $210922 |
| 2027 | 34990 |
| **Total** | $**245912** |

---

(iii) Pursuant to the terms of agreements with various other contract research organizations, the Corporation is committed for the following contract research services:

---

| | |
|:---|:---|
| **Fiscal year** | |
| 2026 | $1135032 |
| 2027 | 508360 |
| 2028 | 45833 |
| 2029 | 22196 |
| **Total** | $**1711421** |

---

**Breakdown of Expensed Research and Development**

---

| | | |
|:---|:---|:---|
|  | **Three months ended**<br> **March 31, 2026** | **Three months ended** <br> **March 31, 2025** |
| Contract research | $3236819 | $2294701 |
| Wages | 747497 | 820246 |
| Supplies |  | 6462 |
| Regulatory | 228373 | 327375 |
| Share-based compensation | 736722 | 308628 |
|  | $**4949411** | $**3757412** |

---

**Internal Controls Over Financial Reporting**

In accordance with National Instrument 52-109 – Certification of Disclosure in Issuers' Annual and Interim Filings, Management is responsible for establishing and maintaining adequate Disclosure Controls and Procedures ("DCP") and Internal Control Over Financial Reporting ("ICFR"). Management has designed DCP and ICFR based on the 2013 Internal Control Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission ("COSO"), with the objective of providing reasonable assurance that the Corporation's financial reports and information, including the Corporation's Financial Statements and MD&A were prepared in accordance with IFRS Accounting Standards. The CEO and CFO have concluded that the DCP and ICFR were adequately designed and operating effectively to provide such assurance as at March 31, 2026.

**Limitations of Controls and Procedures**

The Corporation's Management, including the CEO and CFO, believes that any DCP or ICFR, no matter how well conceived and operated, can provide only reasonable, not absolute, assurance that the objectives of the control system are met. Further, the design of a control system must reflect the fact that there are resource constraints, and the benefits of controls must be considered relative to their costs. Because of the inherent limitations in all control systems, they cannot provide absolute assurance that all control issues and instances of fraud, if any, within the Corporation have been prevented or detected. These inherent limitations include the realities that judgments in decision-making can be faulty, and that breakdowns can occur because of simple error or mistake. Additionally, controls can be circumvented by the individual acts of some persons, by collusion of two or more people, or by unauthorized override of the control. The design of any control system is also based in part upon certain assumptions about the likelihood of future events, and there can be no assurance that any design will succeed in achieving its stated goals under all potential future conditions. Accordingly, because of the inherent limitations in a cost-effective control system, misstatements due to error or fraud may occur and not be detected.

There have been no changes in internal controls over financial reporting for the quarter ended March 31, 2026, that have materially affected, or are reasonably likely to materially affect, the Corporation's ICFR.

**Risk Factors**

An investment in the securities of the Corporation is highly speculative and involves numerous and significant risks. Such investment should be undertaken only by investors whose financial resources are sufficient to enable them to assume these risks. Prospective investors should carefully consider the risk factors that have affected, and which in the future are reasonably expected to affect, the Corporation and its financial position. Please refer to the section entitled "Risk Factors" in the Corporation's MD&A for the financial year ended December 31, 2025 (available on SEDAR+ at sepdarplus.ca and EDGAR at www.sec.gov).

**References**

1. Bragazzi NL, Zhong W, Shu J, *et al*. Burden of heart failure and underlying causes in 195 countries and territories from 1990 to 2017. *Eur J Prev Cardiol. 2021*;28(15):1682-1690. doi:10.1093/eurjpc/zwaa147

Tsao CW et al.; American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association. Circulation. 2023 Jan 25.

2. Adler Y, Charron P. The 2015 ESC Guidelines on the diagnosis and management of pericardial diseases. *Eur Heart J. 2015;36(42):2873-2874. doi:10.1093/eurheartj/ehv479*

Chiabrando JG, Bonaventura A, Vecchié A, *et al.* Management of Acute and Recurrent Pericarditis: JACC State-of-the-Art Review. *J Am Coll Cardiol*. 2020;75(1):76-92. doi:10.1016/j.jacc.2019.11.021

Lin D, Laliberté F, Majeski C, *et al*. Disease and economic burden associated with recurrent pericarditis in a privately insured United States population. Adv Ther . 2021;38(10):5127.

Luis SA, LeWinter MM, Magestro M, *et al*. Estimating the U.S. pericarditis prevalence using national health encounter surveillance databases. *Curr Med Res Opin*. 2022;38(8):1385-1389. doi:10.1080/03007995.2022.2070381

Klein A, Cremer P, Kontzias A, *et al*. U.S. Database Study of Clinical Burden and Unmet Need in Recurrent Pericarditis. *J Am Heart Assoc*. 2021;10(15):e018950. doi:10.1161/JAHA.120.018950

Imazio M, Brucato A, Adler Y. A randomized trial of colchicine for acute pericarditis. *N Engl J Med*. 2014;370(8):781. doi:10.1056/NEJMc1315351

Tingle LE, Molina D, Calvert CW. Acute pericarditis. *Am Fam Physician*. 2007;76(10):1509-1514.

Kytö V, Sipilä J, Rautava P. Clinical profile and influences on outcomes in patients hospitalized for acute pericarditis. *Circulation*. 2014;130(18):1601-1606. doi:10.1161/CIRCULATIONAHA.114.010376

Mody P, Bikdeli B, Wang Y, Imazio M, Krumholz HM. Trends in acute pericarditis hospitalizations and outcomes among the elderly in the USA, 1999-2012. *Eur Heart J Qual Care Clin Outcomes*. 2018;4(2):98-105. doi:10.1093/ehjqcco/qcx040

3. Ammirati E, Cipriani M, Moro C, *et al*. Clinical Presentation and Outcome in a Contemporary Cohort of Patients With Acute Myocarditis: Multicenter Lombardy Registry. *Circulation*. 2018;138(11):1088-1099. doi:10.1161/CIRCULATIONAHA.118.035319

Ammirati E, Moslehi JJ. Diagnosis and Treatment of Acute Myocarditis: A Review. *JAMA*. 2023;329(13):1098-1113. doi:10.1001/jama.2023.3371

Basso C. Myocarditis. *N Engl J Med*. 2022; 387(16):1488-1500. doi:10.1056/NEJMra2114478

Bemtgen X, Kaier K, Rilinger J, *et al.* Myocarditis mortality with and without COVID-19: insights from a national registry. *Clin Res Cardiol*. 2024;113(2):216-222. doi:10.1007/s00392-022-02141-9

Khorolsky, C, Shi, J, Chkhikvadze, T. TRENDS IN HOSPITALIZATION COSTS, LENGTH OF STAY AND COMPLICATIONS AMONG PATIENTS WITH ACUTE MYOCARDITIS: A 10-YEAR UNITED STATES PERSPECTIVE. *J Am Coll Cardiol*. 2019 Mar, 73 (9_Supplement_1) 935.

Lynge TH, Nielsen TS, Gregers Winkel B, Tfelt-Hansen J, Banner J. Sudden cardiac death caused by myocarditis in persons aged 1-49 years: a nationwide study of 14?294 deaths in Denmark. *Forensic Sci Res*. 2019;4(3):247-256. Published 2019 Aug 19. doi:10.1080/20961790.2019.1595352

Tschöpe C, Ammirati E, Bozkurt B, *et al.* Myocarditis and inflammatory cardiomyopathy: current evidence and future directions. *Nat Rev Cardiol*. 2021;18(3):169-193. doi:10.1038/s41569-020-00435-x

Wang X, Bu X, Wei L, Liu J, Yang D, Mann DL, Ma A and Hayashi T (2021) Global, Regional, and National Burden of Myocarditis From 1990 to 2017: A Systematic Analysis Based on the Global Burden of Disease Study 2017. Front. Cardiovasc. Med. 8:692990. doi: 10.3389/fcvm.2021.692990

## Exhibit 99.3

**Exhibit 99.3**

**FORM 52-109F2**

***CERTIFICATION OF INTERIM FILINGS***

***FULL CERTIFICATE***

I, **David Elsley, President and Chief Executive Officer of Cardiol Therapeutics Inc.**, certify the following:

1.  ***Review:*** I have reviewed the interim financial report and interim MD&A (together, the "interim filings")
of **Cardiol Therapeutics Inc.** (the "issuer") for the interim period ended March 31, 2026.

2.  ***No misrepresentations:*** Based on my knowledge, having exercised reasonable diligence, the interim filings do not contain
any untrue statement of a material fact or omit to state a material fact required to be stated or that is necessary to make a statement
not misleading in light of the circumstances under which it was made, with respect to the period covered by the interim filings.

3.  ***Fair presentation:*** Based on my knowledge, having exercised reasonable diligence, the interim financial report together
with the other financial information included in the interim filings fairly present in all material respects the financial condition,
financial performance and cash flows of the issuer, as of the date of and for the periods presented in the interim filings.

4.  ***Responsibility:*** The issuer's other certifying officer(s) and I are responsible for establishing and maintaining
disclosure controls and procedures (DC&P) and internal control over financial reporting (ICFR), as those terms are defined in National
Instrument 52-109 *Certification of Disclosure in Issuers' Annual and Interim Filings,* for the issuer.

5.  ***Design:*** Subject to the limitations, if any, described in paragraphs 5.2 and 5.3, the issuer's other certifying
officer(s) and I have, as at the end of the period covered by the interim filings

&nbsp;&nbsp;&nbsp;&nbsp;(a) designed DC&P, or caused it to be designed under our supervision, to provide reasonable assurance that

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) material information relating to the issuer is made known to us by others, particularly during the period in which the interim filings
are being prepared; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) information required to be disclosed by the issuer in its annual filings, interim filings or other reports filed or submitted by it
under securities legislation is recorded, processed, summarized and reported within the time periods specified in securities legislation;
and

&nbsp;&nbsp;&nbsp;&nbsp;(b) designed ICFR, or caused it to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial
reporting and the preparation of financial statements for external purposes in accordance with the issuer's GAAP.

5.1  ***Control framework:*** The control framework the issuer's other certifying officer(s) and I used to design the
issuer's ICFR is 2013 Internal Control Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway
Commission ("COSO").

5.2  ***N/A*** 

5.3  ***N/A*** 

6.  ***Reporting changes in ICFR:*** The issuer has disclosed in its interim MD&A any change in the issuer's ICFR that
occurred during the period beginning January 1, 2026 and ended on March 31, 2026 that has materially affected, or is reasonably
likely to materially affect, the issuer's ICFR.

Date: **May 11, 2026**

"David Elsley" <br> David Elsley <br> President and Chief Executive Officer

## Exhibit 99.4

**Exhibit 99.4** 

**FORM 52-109F2**

***CERTIFICATION OF INTERIM FILINGS***

***FULL CERTIFICATE***

I, **Christopher Waddick, Chief Financial Officer of Cardiol Therapeutics Inc.**, certify the following:

1.  ***Review:*** I have reviewed the interim financial report and interim MD&A (together, the "interim filings")
of **Cardiol Therapeutics Inc.** (the "issuer") for the interim period ended March 31, 2026.

2.  ***No misrepresentations:*** Based on my knowledge, having exercised reasonable diligence, the interim filings do not contain
any untrue statement of a material fact or omit to state a material fact required to be stated or that is necessary to make a statement
not misleading in light of the circumstances under which it was made, with respect to the period covered by the interim filings.

3.  ***Fair presentation:*** Based on my knowledge, having exercised reasonable diligence, the interim financial report together
with the other financial information included in the interim filings fairly present in all material respects the financial condition,
financial performance and cash flows of the issuer, as of the date of and for the periods presented in the interim filings.

4.  ***Responsibility:*** The issuer's other certifying officer(s) and I are responsible for establishing and maintaining
disclosure controls and procedures (DC&P) and internal control over financial reporting (ICFR), as those terms are defined in National
Instrument 52-109 *Certification of Disclosure in Issuers' Annual and Interim Filings,* for the issuer.

5.  ***Design:*** Subject to the limitations, if any, described in paragraphs 5.2 and 5.3, the issuer's other certifying
officer(s) and I have, as at the end of the period covered by the interim filings

&nbsp;&nbsp;&nbsp;&nbsp;(a) designed DC&P, or caused it to be designed under our supervision, to provide reasonable assurance that

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) material information relating to the issuer is made known to us by others, particularly during the period in which the interim filings
are being prepared; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) information required to be disclosed by the issuer in its annual filings, interim filings or other reports filed or submitted by it
under securities legislation is recorded, processed, summarized and reported within the time periods specified in securities legislation;
and

&nbsp;&nbsp;&nbsp;&nbsp;(b) designed ICFR, or caused it to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial
reporting and the preparation of financial statements for external purposes in accordance with the issuer's GAAP.

5.1  ***Control framework:*** The control framework the issuer's other certifying officer(s) and I used to design the
issuer's ICFR is 2013 Internal Control Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway
Commission ("COSO").

5.2  ***N/A*** 

5.3  ***N/A*** 

6.  ***Reporting changes in ICFR:*** The issuer has disclosed in its interim MD&A any change in the issuer's ICFR that
occurred during the period beginning January 1, 2026 and ended on March 31, 2026 that has materially affected, or is reasonably
likely to materially affect, the issuer's ICFR.

Date: **May 11, 2026**

"Christopher Waddick" <br> Christopher Waddick <br> Chief Financial Officer