# EDGAR Filing Document

**Accession Number:** 0001757499
**File Stem:** 0000000000-25-011587
**Filing Date:** 2025-12
**Character Count:** 3926
**Document Hash:** d34f9308cda47c6be9ce791069b3d048
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000000000-25-011587.hdr.sgml**: 20260319

**ACCESSION NUMBER**: 0000000000-25-011587

**CONFORMED SUBMISSION TYPE**: UPLOAD

**PUBLIC DOCUMENT COUNT**: 2

**FILED AS OF DATE**: 20251215

**FILED FOR**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Shuttle Pharmaceuticals Holdings, Inc.
- **CENTRAL INDEX KEY:** 0001757499
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** UPLOAD
- **SEC FILE NUMBER:** 333-291628

**BUSINESS ADDRESS:**
- **STREET 1:** 401 PROFESSIONAL DRIVE
- **STREET 2:** SUITE 260
- **CITY:** GAITHERSBURG
- **STATE:** MD
- **ZIP:** 20879
- **BUSINESS PHONE:** (240) 403-4212

**MAIL ADDRESS:**
- **STREET 1:** 401 PROFESSIONAL DRIVE
- **STREET 2:** SUITE 260
- **CITY:** GAITHERSBURG
- **STATE:** MD
- **ZIP:** 20879
**PUBLIC REFERENCE ACCESSION NUMBER**: 0001493152-25-024089

## Text-Extract

```

                                                            December 15, 2025

Christopher Cooper
Interim Chief Executive Officer
Shuttle Pharmaceuticals Holdings, Inc.
401 Professional Drive, Suite 260
Gaithersburg, MD 20879

       Re: Shuttle Pharmaceuticals Holdings, Inc.
           Amendment No. 1 to Registration Statement on Form S-1
           Filed December 11, 2025
           File No. 333-291628
Dear Christopher Cooper:

       We have conducted a limited review of your registration statement and
have the
following comment.

        Please respond to this letter by amending your registration statement
and providing
the requested information. If you do not believe our comment applies to your
facts and
circumstances or do not believe an amendment is appropriate, please tell us why
in your
response.

       After reviewing any amendment to your registration statement and the
information
you provide in response to this letter, we may have additional comments.

Amendment No. 1 to Registration Statement on Form S-1
General

1.     We note your disclosure in your registration statement and in your Form
8-K filed
       November 26, 2025, incorporated by reference into the registration
       statement, indicating that a wholly owned subsidiary of your company
acquired
       substantially all of the assets and liabilities of Molecule.ai and that
you plan to
       discontinue clinical trials of your lead product candidate. We further
note the
       consideration payable by your company consisted of a one-time cash
contribution of
       $3M, a first installment contribution equal to $3M, a second installment
contribution
       equal to $2M and two contingent contributions. Please revise to include
acquired
       company financial statements for Molecule.ai, including pro forma
financial
       statements. Alternatively, please tell us why these financial statements
are not
       required. Refer to Rule 11-01(d) of Regulation S-X.
 December 15, 2025
Page 2

        We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence
of action by the staff.

       Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration
statement.

       Please contact Alan Campbell at 202-551-4224 or Laura Crotty at
202-551-7614 with
any questions.

                                                           Sincerely,

                                                           Division of
Corporation Finance
                                                           Office of Life
Sciences
cc:   Aaron M. Schleicher, Esq.

```

### Attached PDF Documents

**Attachment 1:** `filename1`

_No text found in this document._