# EDGAR Filing Document

**Accession Number:** 0002056052
**File Stem:** 0002056052-26-000002
**Filing Date:** 2026-2
**Character Count:** 44901
**Document Hash:** 7ab72de3bd9776cf10f8b7718e8908bd
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0002056052-26-000002.hdr.sgml**: 20260217

**ACCESSION NUMBER**: 0002056052-26-000002

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20251231

**FILED AS OF DATE**: 20260217

**DATE AS OF CHANGE**: 20260217

**EFFECTIVENESS DATE**: 20260217

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Persistent Asset Partners Ltd
- **CENTRAL INDEX KEY:** 0002056052

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** K3
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-25300
- **FILM NUMBER:** 26635874

**BUSINESS ADDRESS:**
- **STREET 1:** TWO EXCHANGE SQUARE, 8 CONNAUGHT PLACE
- **STREET 2:** SUITE 1901
- **CITY:** HONG KONG
- **STATE:** K3
- **ZIP:** 00000
- **BUSINESS PHONE:** 852 3793 3700

**MAIL ADDRESS:**
- **STREET 1:** TWO EXCHANGE SQUARE, 8 CONNAUGHT PLACE
- **STREET 2:** SUITE 1901
- **CITY:** HONG KONG
- **STATE:** K3
- **ZIP:** 00000

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2025

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** Persistent Asset Partners Ltd<br>**Address:** TWO EXCHANGE SQUARE 8 CONNAUGHT PLACE<br>SUITE 1901<br>HONG KONG, K3 00000

**Form 13F File Number:** 028-25300

**CRD Number (if applicable):** 000177528

**SEC File Number (if applicable):** 802-89175

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Dawn Yu<br>**Title:** Responsible Officer<br>**Phone:** 852-3793-3913

**Signature, Place, and Date of Signing:**

Dawn Yu  Hong Kong, K3  02-17-2026<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 421

**Form 13F Information Table Value Total:** $222667256

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| ARBOR REALTY TRUST INC | CALL | 038923908 |  | 3377 | 335 | SH | Call | SOLE | 0 | 335 | 0 | 0 |
| AGNC INVT CORP | CALL | 00123Q904 |  | 3744 | 936 | SH | Call | SOLE | 0 | 936 | 0 | 0 |
| ROCKET COS INC | CALL | 77311W901 |  | 8164 | 90 | SH | Call | SOLE | 0 | 90 | 0 | 0 |
| SOFI TECHNOLOGIES INC | CALL | 83406F902 |  | 6063 | 94 | SH | Call | SOLE | 0 | 94 | 0 | 0 |
| ABIVAX SA | SPONSORED ADS | 00370M103 |  | 3292215 | 20214 | SH |  | SOLE | 0 | 20214 | 0 | 0 |
| ARBUTUS BIOPHARMA CORP | CALL | 03879J900 |  | 190828 | 1484 | SH | Call | SOLE | 0 | 1484 | 0 | 0 |
| ALTIMMUNE INC | CALL | 02155H900 |  | 13 | 1324 | SH | Call | SOLE | 0 | 1324 | 0 | 0 |
| ANNEXON INC | CALL | 03589W902 |  | 117925 | 536 | SH | Call | SOLE | 0 | 536 | 0 | 0 |
| ANNEXON INC | CALL | 03589W902 |  | 49634 | 292 | SH | Call | SOLE | 0 | 292 | 0 | 0 |
| APOGEE THERAPEUTICS INC | CALL | 03770N901 |  | 1640534 | 566 | SH | Call | SOLE | 0 | 566 | 0 | 0 |
| APPLIED THERAPEUTICS INC | CALL | 03828A901 |  | 1 | 55 | SH | Call | SOLE | 0 | 55 | 0 | 0 |
| AQUESTIVE THERAPEUTICS INC | CALL | 03843E904 |  | 64960 | 566 | SH | Call | SOLE | 0 | 566 | 0 | 0 |
| ATYR PHARMA INC | CALL | 002120902 |  | 129 | 28 | SH | Call | SOLE | 0 | 28 | 0 | 0 |
| ATYR PHARMA INC | CALL | 002120902 |  | 0 | 8 | SH | Call | SOLE | 0 | 8 | 0 | 0 |
| ANAVEX LIFE SCIENCES CORP | CALL | 032797900 |  | 4804 | 322 | SH | Call | SOLE | 0 | 322 | 0 | 0 |
| BRIDGEBIO PHARMA INC | CALL | 10806X902 |  | 867804 | 376 | SH | Call | SOLE | 0 | 376 | 0 | 0 |
| BLACK DIAMOND THERAPEUTICS I | CALL | 09203E905 |  | 13143 | 512 | SH | Call | SOLE | 0 | 512 | 0 | 0 |
| BIOHAVEN LTD | CALL | G1110E907 |  | 180900 | 536 | SH | Call | SOLE | 0 | 536 | 0 | 0 |
| BIOAGE LABS INC | CALL | 09077V900 |  | 20315 | 61 | SH | Call | SOLE | 0 | 61 | 0 | 0 |
| CAPRICOR THERAPEUTICS INC | CALL | 14070B909 |  | 964351 | 831 | SH | Call | SOLE | 0 | 831 | 0 | 0 |
| CENTESSA PHARMACEUTICALS PLC | CALL | 152309900 |  | 15478 | 57 | SH | Call | SOLE | 0 | 57 | 0 | 0 |
| CRISPR THERAPEUTICS AG | CALL | H17182908 |  | 7544 | 124 | SH | Call | SOLE | 0 | 124 | 0 | 0 |
| CRISPR THERAPEUTICS AG | CALL | H17182908 |  | 3271 | 134 | SH | Call | SOLE | 0 | 134 | 0 | 0 |
| EDITAS MEDICINE INC | CALL | 28106W903 |  | 34 | 862 | SH | Call | SOLE | 0 | 862 | 0 | 0 |
| EVOLUS INC | CALL | 30052C907 |  | 32595 | 318 | SH | Call | SOLE | 0 | 318 | 0 | 0 |
| GOSSAMER BIO INC | CALL | 38341P902 |  | 80399 | 377 | SH | Call | SOLE | 0 | 377 | 0 | 0 |
| GOSSAMER BIO INC | CALL | 38341P902 |  | 234066 | 1433 | SH | Call | SOLE | 0 | 1433 | 0 | 0 |
| GOSSAMER BIO INC | CALL | 38341P902 |  | 13847 | 591 | SH | Call | SOLE | 0 | 591 | 0 | 0 |
| STRUCTURE THERAPEUTICS INC | CALL | 86366E906 |  | 972930 | 246 | SH | Call | SOLE | 0 | 246 | 0 | 0 |
| STRUCTURE THERAPEUTICS INC | CALL | 86366E906 |  | 985530 | 266 | SH | Call | SOLE | 0 | 266 | 0 | 0 |
| INDIVIOR PLC | CALL | G4766E906 |  | 158643 | 587 | SH | Call | SOLE | 0 | 587 | 0 | 0 |
| INOVIO PHARMACEUTICALS INC | CALL | 45773H909 |  | 7497 | 267 | SH | Call | SOLE | 0 | 267 | 0 | 0 |
| INSMED INC | CALL | 457669907 |  | 20336 | 142 | SH | Call | SOLE | 0 | 142 | 0 | 0 |
| IONIS PHARMACEUTICALS INC | CALL | 462222900 |  | 432183 | 285 | SH | Call | SOLE | 0 | 285 | 0 | 0 |
| JANUX THERAPEUTICS INC | CALL | 47103J905 |  | 25997 | 80 | SH | Call | SOLE | 0 | 80 | 0 | 0 |
| JAZZ PHARMACEUTICALS PLC | CALL | G50871905 |  | 327946 | 277 | SH | Call | SOLE | 0 | 277 | 0 | 0 |
| JAZZ PHARMACEUTICALS PLC | CALL | G50871905 |  | 651 | 6 | SH | Call | SOLE | 0 | 6 | 0 | 0 |
| JOHNSON  JOHNSON | CALL | 478160904 |  | 2860 | 133 | SH | Call | SOLE | 0 | 133 | 0 | 0 |
| KODIAK SCIENCES INC | CALL | 50015M909 |  | 182078 | 80 | SH | Call | SOLE | 0 | 80 | 0 | 0 |
| LEGEND BIOTECH CORP | CALL | 52490G902 |  | 2760 | 184 | SH | Call | SOLE | 0 | 184 | 0 | 0 |
| MOONLAKE IMMUNOTHERAPEUTICS | CALL | 61559X904 |  | 30292 | 126 | SH | Call | SOLE | 0 | 126 | 0 | 0 |
| MANNKIND CORP | CALL | 56400P906 |  | 8925 | 1490 | SH | Call | SOLE | 0 | 1490 | 0 | 0 |
| MEREO BIOPHARMA GROUP PLC | CALL | 589492907 |  | 4 | 36 | SH | Call | SOLE | 0 | 36 | 0 | 0 |
| MEREO BIOPHARMA GROUP PLC | CALL | 589492907 |  | 33 | 3301 | SH | Call | SOLE | 0 | 3301 | 0 | 0 |
| MEREO BIOPHARMA GROUP PLC | CALL | 589492907 |  | 20 | 2022 | SH | Call | SOLE | 0 | 2022 | 0 | 0 |
| INTELLIA THERAPEUTICS INC | CALL | 45826J905 |  | 866 | 570 | SH | Call | SOLE | 0 | 570 | 0 | 0 |
| OCULAR THERAPEUTIX INC | CALL | 67576A900 |  | 14740 | 536 | SH | Call | SOLE | 0 | 536 | 0 | 0 |
| OCULAR THERAPEUTIX INC | CALL | 67576A900 |  | 81570 | 533 | SH | Call | SOLE | 0 | 533 | 0 | 0 |
| OCULAR THERAPEUTIX INC | CALL | 67576A900 |  | 214243 | 390 | SH | Call | SOLE | 0 | 390 | 0 | 0 |
| OLEMA PHARMACEUTICALS INC | CALL | 68062P906 |  | 527855 | 260 | SH | Call | SOLE | 0 | 260 | 0 | 0 |
| PUMA BIOTECHNOLOGY INC | CALL | 74587V907 |  | 3868 | 91 | SH | Call | SOLE | 0 | 91 | 0 | 0 |
| ULTRAGENYX PHARMACEUTICAL IN | CALL | 90400D908 |  | 1133 | 266 | SH | Call | SOLE | 0 | 266 | 0 | 0 |
| REGENERON PHARMACEUTICALS | CALL | 75886F907 |  | 43943 | 13 | SH | Call | SOLE | 0 | 13 | 0 | 0 |
| AVIDITY BIOSCIENCES INC | CALL | 05370A908 |  | 1308629 | 570 | SH | Call | SOLE | 0 | 570 | 0 | 0 |
| AVIDITY BIOSCIENCES INC | CALL | 05370A908 |  | 1829 | 1 | SH | Call | SOLE | 0 | 1 | 0 | 0 |
| AVIDITY BIOSCIENCES INC | CALL | 05370A908 |  | 54788 | 40 | SH | Call | SOLE | 0 | 40 | 0 | 0 |
| AVIDITY BIOSCIENCES INC | CALL | 05370A908 |  | 115024 | 228 | SH | Call | SOLE | 0 | 228 | 0 | 0 |
| REVIVA PHARMACEUTCLS HLDGS I | CALL | 76152G900 |  | 228 | 1138 | SH | Call | SOLE | 0 | 1138 | 0 | 0 |
| RECURSION PHARMACEUTICALS IN | CALL | 75629V904 |  | 11 | 1128 | SH | Call | SOLE | 0 | 1128 | 0 | 0 |
| ABIVAX SA | SPONSORED ADS | 00370M103 |  | 566256 | 4199 | SH |  | SOLE | 0 | 4199 | 0 | 0 |
| RECURSION PHARMACEUTICALS IN | CALL | 75629V904 |  | 9 | 871 | SH | Call | SOLE | 0 | 871 | 0 | 0 |
| SOLENO THERAPEUTICS INC | CALL | 834203909 |  | 425 | 143 | SH | Call | SOLE | 0 | 143 | 0 | 0 |
| SELLAS LIFE SCIENCES GROUP I | CALL | 81642T909 |  | 37213 | 1145 | SH | Call | SOLE | 0 | 1145 | 0 | 0 |
| TECTONIC THERAPEUTIC INC | CALL | 878972908 |  | 44087 | 229 | SH | Call | SOLE | 0 | 229 | 0 | 0 |
| TERNS PHARMACEUTICALS INC | CALL | 880881907 |  | 463528 | 147 | SH | Call | SOLE | 0 | 147 | 0 | 0 |
| VIR BIOTECHNOLOGY INC | CALL | 92764N902 |  | 20808 | 225 | SH | Call | SOLE | 0 | 225 | 0 | 0 |
| VIR BIOTECHNOLOGY INC | CALL | 92764N902 |  | 134 | 13 | SH | Call | SOLE | 0 | 13 | 0 | 0 |
| VIKING THERAPEUTICS INC | CALL | 92686J906 |  | 26820 | 15 | SH | Call | SOLE | 0 | 15 | 0 | 0 |
| VIKING THERAPEUTICS INC | CALL | 92686J906 |  | 109811 | 99 | SH | Call | SOLE | 0 | 99 | 0 | 0 |
| VIKING THERAPEUTICS INC | CALL | 92686J906 |  | 924214 | 561 | SH | Call | SOLE | 0 | 561 | 0 | 0 |
| VIKING THERAPEUTICS INC | CALL | 92686J906 |  | 97108 | 99 | SH | Call | SOLE | 0 | 99 | 0 | 0 |
| VIKING THERAPEUTICS INC | CALL | 92686J906 |  | 40270 | 799 | SH | Call | SOLE | 0 | 799 | 0 | 0 |
| VIKING THERAPEUTICS INC | CALL | 92686J906 |  | 7344 | 266 | SH | Call | SOLE | 0 | 266 | 0 | 0 |
| VANDA PHARMACEUTICALS INC | CALL | 921659908 |  | 56975 | 530 | SH | Call | SOLE | 0 | 530 | 0 | 0 |
| VERTEX PHARMACEUTICALS INC | CALL | 92532F900 |  | 467280 | 236 | SH | Call | SOLE | 0 | 236 | 0 | 0 |
| VISTAGEN THERAPEUTICS INC | CALL | 92840H900 |  | 3 | 287 | SH | Call | SOLE | 0 | 287 | 0 | 0 |
| ZYMEWORKS INC | CALL | 98985Y908 |  | 234574 | 363 | SH | Call | SOLE | 0 | 363 | 0 | 0 |
| ZYMEWORKS INC | CALL | 98985Y908 |  | 123970 | 286 | SH | Call | SOLE | 0 | 286 | 0 | 0 |
| AQUESTIVE THERAPEUTICS INC | PUT | 03843E954 |  | 59443 | 906 | SH | Put | SOLE | 0 | 906 | 0 | 0 |
| ATYR PHARMA INC | PUT | 002120952 |  | 5225 | 27 | SH | Put | SOLE | 0 | 27 | 0 | 0 |
| BRIDGEBIO PHARMA INC | PUT | 10806X952 |  | 71996 | 536 | SH | Put | SOLE | 0 | 536 | 0 | 0 |
| CAPRICOR THERAPEUTICS INC | PUT | 14070B959 |  | 19157 | 266 | SH | Put | SOLE | 0 | 266 | 0 | 0 |
| CAPRICOR THERAPEUTICS INC | PUT | 14070B959 |  | 36293 | 267 | SH | Put | SOLE | 0 | 267 | 0 | 0 |
| CORCEPT THERAPEUTICS INC | PUT | 218352952 |  | 105 | 2 | SH | Put | SOLE | 0 | 2 | 0 | 0 |
| CORCEPT THERAPEUTICS INC | PUT | 218352952 |  | 1073 | 1 | SH | Put | SOLE | 0 | 1 | 0 | 0 |
| CORCEPT THERAPEUTICS INC | PUT | 218352952 |  | 442035 | 284 | SH | Put | SOLE | 0 | 284 | 0 | 0 |
| CORCEPT THERAPEUTICS INC | PUT | 218352952 |  | 190247 | 75 | SH | Put | SOLE | 0 | 75 | 0 | 0 |
| CORMEDIX INC | PUT | 21900C958 |  | 59246 | 427 | SH | Put | SOLE | 0 | 427 | 0 | 0 |
| CORVUS PHARMACEUTICALS INC | PUT | 221015950 |  | 7508 | 142 | SH | Put | SOLE | 0 | 142 | 0 | 0 |
| INCYTE CORP | PUT | 45337C952 |  | 329010 | 266 | SH | Put | SOLE | 0 | 266 | 0 | 0 |
| JADE BIOSCIENCES INC | PUT | 008064956 |  | 8949 | 88 | SH | Put | SOLE | 0 | 88 | 0 | 0 |
| LYELL IMMUNOPHARMA INC | PUT | 55083R953 |  | 16295 | 10 | SH | Put | SOLE | 0 | 10 | 0 | 0 |
| INTELLIA THERAPEUTICS INC | PUT | 45826J955 |  | 117695 | 852 | SH | Put | SOLE | 0 | 852 | 0 | 0 |
| NOVO-NORDISK A S | PUT | 670100955 |  | 197759 | 143 | SH | Put | SOLE | 0 | 143 | 0 | 0 |
| PRAXIS PRECISION MEDICINES I | PUT | 74006W957 |  | 15601 | 230 | SH | Put | SOLE | 0 | 230 | 0 | 0 |
| INVESCO QQQ TR | PUT | 46090E953 |  | 6882 | 81 | SH | Put | SOLE | 0 | 81 | 0 | 0 |
| UNIQURE NV | PUT | N90064951 |  | 36489 | 229 | SH | Put | SOLE | 0 | 229 | 0 | 0 |
| UNIQURE NV | PUT | N90064951 |  | 143773 | 459 | SH | Put | SOLE | 0 | 459 | 0 | 0 |
| ROIVANT SCIENCES LTD | PUT | G76279951 |  | 25826 | 860 | SH | Put | SOLE | 0 | 860 | 0 | 0 |
| CASSAVA SCIENCES INC | PUT | 14817C957 |  | 1630 | 30 | SH | Put | SOLE | 0 | 30 | 0 | 0 |
| TG THERAPEUTICS INC | PUT | 88322Q958 |  | 24200 | 265 | SH | Put | SOLE | 0 | 265 | 0 | 0 |
| TRAVERE THERAPEUTICS INC | PUT | 89422G957 |  | 74 | 1 | SH | Put | SOLE | 0 | 1 | 0 | 0 |
| TRAVERE THERAPEUTICS INC | PUT | 89422G957 |  | 13006 | 133 | SH | Put | SOLE | 0 | 133 | 0 | 0 |
| VIKING THERAPEUTICS INC | PUT | 92686J956 |  | 52532 | 851 | SH | Put | SOLE | 0 | 851 | 0 | 0 |
| SPDR SERIES TRUST | PUT | 78464A950 |  | 12071 | 536 | SH | Put | SOLE | 0 | 536 | 0 | 0 |
| SPDR SERIES TRUST | PUT | 78464A950 |  | 24178 | 133 | SH | Put | SOLE | 0 | 133 | 0 | 0 |
| ZYMEWORKS INC | PUT | 98985Y958 |  | 1 | 57 | SH | Put | SOLE | 0 | 57 | 0 | 0 |
| TESLA INC | CALL | 88160R901 |  | 130 | 7 | SH | Call | SOLE | 0 | 7 | 0 | 0 |
| NVIDIA CORPORATION | CALL | 67066G904 |  | 3858 | 9 | SH | Call | SOLE | 0 | 9 | 0 | 0 |
| KRATOS DEFENSE  SEC SOLUTIO | CALL | 50077B907 |  | 225 | 10 | SH | Call | SOLE | 0 | 10 | 0 | 0 |
| GOLDMAN SACHS GROUP INC | CALL | 38141G904 |  | 36 | 2 | SH | Call | SOLE | 0 | 2 | 0 | 0 |
| CATERPILLAR INC | CALL | 149123901 |  | 72 | 9 | SH | Call | SOLE | 0 | 9 | 0 | 0 |
| INTUITIVE SURGICAL INC | CALL | 46120E902 |  | 401 | 4 | SH | Call | SOLE | 0 | 4 | 0 | 0 |
| ABRDN PALLADIUM ETF TRUST | CALL | 003262902 |  | 5220 | 12 | SH | Call | SOLE | 0 | 12 | 0 | 0 |
| ISHARES SILVER TR | CALL | 46428Q909 |  | 2118 | 35 | SH | Call | SOLE | 0 | 35 | 0 | 0 |
| TWILIO INC | CALL | 90138F902 |  | 5092 | 15 | SH | Call | SOLE | 0 | 15 | 0 | 0 |
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 |  | 1234746 | 42784 | SH |  | SOLE | 0 | 42784 | 0 | 0 |
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 |  | 250995 | 8697 | SH |  | SOLE | 0 | 8697 | 0 | 0 |
| CENTENE CORP DEL | COM | 15135B101 |  | 8717833 | 211855 | SH |  | SOLE | 0 | 211855 | 0 | 0 |
| CENTENE CORP DEL | COM | 15135B101 |  | 356976 | 8675 | SH |  | SOLE | 0 | 8675 | 0 | 0 |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 |  | 600690 | 24018 | SH |  | SOLE | 0 | 24018 | 0 | 0 |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 |  | 481392 | 19248 | SH |  | SOLE | 0 | 19248 | 0 | 0 |
| COGENT BIOSCIENCES INC | COM | 19240Q201 |  | 1252435 | 35260 | SH |  | SOLE | 0 | 35260 | 0 | 0 |
| COGENT BIOSCIENCES INC | COM | 19240Q201 |  | 434729 | 12239 | SH |  | SOLE | 0 | 12239 | 0 | 0 |
| DESIGN THERAPEUTICS INC | COM | 25056L103 |  | 250756 | 26733 | SH |  | SOLE | 0 | 26733 | 0 | 0 |
| DESIGN THERAPEUTICS INC | COM | 25056L103 |  | 77441 | 8256 | SH |  | SOLE | 0 | 8256 | 0 | 0 |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 |  | 198495 | 7999 | SH |  | SOLE | 0 | 7999 | 0 | 0 |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 |  | 327682 | 13205 | SH |  | SOLE | 0 | 13205 | 0 | 0 |
| FOGHORN THERAPEUTICS INC | COM | 344174107 |  | 44356 | 8214 | SH |  | SOLE | 0 | 8214 | 0 | 0 |
| FOGHORN THERAPEUTICS INC | COM | 344174107 |  | 210028 | 38894 | SH |  | SOLE | 0 | 38894 | 0 | 0 |
| HARMONY BIOSCIENCES HLDGS IN | COM | 413197104 |  | 74840 | 2000 | SH |  | SOLE | 0 | 2000 | 0 | 0 |
| HARMONY BIOSCIENCES HLDGS IN | COM | 413197104 |  | 315600 | 8434 | SH |  | SOLE | 0 | 8434 | 0 | 0 |
| IMMUNOME INC | COM | 45257U108 |  | 129116 | 6011 | SH |  | SOLE | 0 | 6011 | 0 | 0 |
| DARLING INGREDIENTS INC | COM | 237266101 |  | 540000 | 15000 | SH |  | SOLE | 0 | 15000 | 0 | 0 |
| EXPAND ENERGY CORPORATION | COM | 165167735 |  | 927907 | 8408 | SH |  | SOLE | 0 | 8408 | 0 | 0 |
| IMMUNOME INC | COM | 45257U108 |  | 54065 | 2517 | SH |  | SOLE | 0 | 2517 | 0 | 0 |
| IMMUNOCORE HLDGS PLC | ADS | 45258D105 |  | 654700 | 18862 | SH |  | SOLE | 0 | 18862 | 0 | 0 |
| SLB LIMITED | COM STK | 806857108 |  | 383800 | 10000 | SH |  | SOLE | 0 | 10000 | 0 | 0 |
| BRIGHTSPRING HEALTH SVCS INC | COM | 10950A106 |  | 3516443 | 93897 | SH |  | SOLE | 0 | 93897 | 0 | 0 |
| IMMUNOCORE HLDGS PLC | ADS | 45258D105 |  | 314820 | 9070 | SH |  | SOLE | 0 | 9070 | 0 | 0 |
| ENHABIT INC | COM | 29332G102 |  | 2100371 | 227806 | SH |  | SOLE | 0 | 227806 | 0 | 0 |
| INTEL CORP | COM | 458140100 |  | 3425796 | 92840 | SH |  | SOLE | 0 | 92840 | 0 | 0 |
| CARDINAL HEALTH INC | COM | 14149Y108 |  | 1170323 | 5695 | SH |  | SOLE | 0 | 5695 | 0 | 0 |
| INTEL CORP | COM | 458140100 |  | 1918800 | 52000 | SH |  | SOLE | 0 | 52000 | 0 | 0 |
| INVENTIVA SA | ADS | 46124U107 |  | 413720 | 88972 | SH |  | SOLE | 0 | 88972 | 0 | 0 |
| INVENTIVA SA | ADS | 46124U107 |  | 189436 | 40739 | SH |  | SOLE | 0 | 40739 | 0 | 0 |
| PACS GROUP INC | COM SHS | 69380Q107 |  | 1034227 | 26940 | SH |  | SOLE | 0 | 26940 | 0 | 0 |
| EHEALTH INC | COM | 28238P109 |  | 448988 | 97606 | SH |  | SOLE | 0 | 97606 | 0 | 0 |
| ALIGNMENT HEALTHCARE INC | COM | 01625V104 |  | 1649974 | 83543 | SH |  | SOLE | 0 | 83543 | 0 | 0 |
| MOLINA HEALTHCARE INC | COM | 60855R100 |  | 8899999 | 51285 | SH |  | SOLE | 0 | 51285 | 0 | 0 |
| LIPOCINE INC NEW | COM NEW | 53630X203 |  | 557692 | 69451 | SH |  | SOLE | 0 | 69451 | 0 | 0 |
| HEALTHCARE SVCS GROUP INC | COM | 421906108 |  | 1277962 | 66839 | SH |  | SOLE | 0 | 66839 | 0 | 0 |
| ELEVANCE HEALTH INC FORMERLY | COM | 036752103 |  | 8076321 | 23039 | SH |  | SOLE | 0 | 23039 | 0 | 0 |
| PENNANT GROUP INC | COM | 70805E109 |  | 10021 | 356 | SH |  | SOLE | 0 | 356 | 0 | 0 |
| CVS HEALTH CORP | COM | 126650100 |  | 1780124 | 22431 | SH |  | SOLE | 0 | 22431 | 0 | 0 |
| NEXGEN ENERGY LTD | COM | 65340P106 |  | 2241734 | 243529 | SH |  | SOLE | 0 | 243529 | 0 | 0 |
| SOLARIS RES INC | COM NEW | 83419D201 |  | 209377 | 26116 | SH |  | SOLE | 0 | 26116 | 0 | 0 |
| INTERCONTINENTAL EXCHANGE IN | COM | 45866F104 |  | 661931 | 4087 | SH |  | SOLE | 0 | 4087 | 0 | 0 |
| EQUINOX GOLD CORP | COM | 29446Y502 |  | 1606190 | 114401 | SH |  | SOLE | 0 | 114401 | 0 | 0 |
| CENOVUS ENERGY INC | COM | 15135U109 |  | 608697 | 35975 | SH |  | SOLE | 0 | 35975 | 0 | 0 |
| ELDORADO GOLD CORP NEW | COM | 284902509 |  | 1808033 | 50335 | SH |  | SOLE | 0 | 50335 | 0 | 0 |
| ALCOA CORP | COM | 013872106 |  | 665579 | 12525 | SH |  | SOLE | 0 | 12525 | 0 | 0 |
| TASEKO MINES LTD | COM | 876511106 |  | 1462142 | 258329 | SH |  | SOLE | 0 | 258329 | 0 | 0 |
| ZILLOW GROUP INC | CL C CAP STK | 98954M200 |  | 773888 | 11344 | SH |  | SOLE | 0 | 11344 | 0 | 0 |
| ANTERIS TECHNOLOGIES GLOBAL | COM | 03675P102 |  | 116352 | 23317 | SH |  | SOLE | 0 | 23317 | 0 | 0 |
| LIPOCINE INC NEW | COM NEW | 53630X203 |  | 9034 | 1125 | SH |  | SOLE | 0 | 1125 | 0 | 0 |
| NEWS CORP NEW | CL B | 65249B208 |  | 915656 | 30903 | SH |  | SOLE | 0 | 30903 | 0 | 0 |
| AFFIRM HLDGS INC | COM CL A | 00827B106 |  | 174092 | 2339 | SH |  | SOLE | 0 | 2339 | 0 | 0 |
| AMERANT BANCORP INC | CL A | 023576101 |  | 703999 | 36084 | SH |  | SOLE | 0 | 36084 | 0 | 0 |
| AMERIS BANCORP | COM | 03076K108 |  | 762901 | 10272 | SH |  | SOLE | 0 | 10272 | 0 | 0 |
| AVIDBANK HLDGS INC | COM | 05368J103 |  | 372716 | 14033 | SH |  | SOLE | 0 | 14033 | 0 | 0 |
| AXOS FINANCIAL INC | COM | 05465C100 |  | 201442 | 2338 | SH |  | SOLE | 0 | 2338 | 0 | 0 |
| BANCORP INC DEL | COM | 05969A105 |  | 1705488 | 25259 | SH |  | SOLE | 0 | 25259 | 0 | 0 |
| BANK AMERICA CORP | COM | 060505104 |  | 1157750 | 21050 | SH |  | SOLE | 0 | 21050 | 0 | 0 |
| CITIGROUP INC | COM NEW | 172967424 |  | 1091752 | 9356 | SH |  | SOLE | 0 | 9356 | 0 | 0 |
| CITIZENS FINL GROUP INC | COM | 174610105 |  | 683163 | 11696 | SH |  | SOLE | 0 | 11696 | 0 | 0 |
| COASTAL FINL CORP WA | COM NEW | 19046P209 |  | 1768811 | 15436 | SH |  | SOLE | 0 | 15436 | 0 | 0 |
| COLUMBIA BKG SYS INC | COM | 197236102 |  | 980570 | 35083 | SH |  | SOLE | 0 | 35083 | 0 | 0 |
| CONNECTONE BANCORP INC | COM | 20786W107 |  | 862376 | 32890 | SH |  | SOLE | 0 | 32890 | 0 | 0 |
| LIQUIDIA CORPORATION | COM NEW | 53635D202 |  | 202215 | 5863 | SH |  | SOLE | 0 | 5863 | 0 | 0 |
| CVB FINL CORP | COM | 126600105 |  | 521972 | 28063 | SH |  | SOLE | 0 | 28063 | 0 | 0 |
| LIQUIDIA CORPORATION | COM NEW | 53635D202 |  | 161172 | 4673 | SH |  | SOLE | 0 | 4673 | 0 | 0 |
| ENOVA INTL INC | COM | 29357K103 |  | 95578 | 608 | SH |  | SOLE | 0 | 608 | 0 | 0 |
| FB FINL CORP | COM | 30257X104 |  | 756927 | 13565 | SH |  | SOLE | 0 | 13565 | 0 | 0 |
| LUMENTUM HLDGS INC | COM | 55024U109 |  | 984135 | 2670 | SH |  | SOLE | 0 | 2670 | 0 | 0 |
| FIRST CTZNS BANCSHARES INC D | CL A | 31946M103 |  | 703947 | 328 | SH |  | SOLE | 0 | 328 | 0 | 0 |
| FIRST WESTN FINL INC | COM | 33751L105 |  | 1009638 | 37659 | SH |  | SOLE | 0 | 37659 | 0 | 0 |
| GREEN DOT CORP | CL A | 39304D102 |  | 419451 | 32744 | SH |  | SOLE | 0 | 32744 | 0 | 0 |
| LINKBANCORP INC | COM | 53578P105 |  | 558194 | 67578 | SH |  | SOLE | 0 | 67578 | 0 | 0 |
| LUMENTUM HLDGS INC | COM | 55024U109 |  | 1105770 | 3000 | SH |  | SOLE | 0 | 3000 | 0 | 0 |
| LIVE OAK BANCSHARES INC | COM | 53803X105 |  | 160621 | 4676 | SH |  | SOLE | 0 | 4676 | 0 | 0 |
| LPL FINL HLDGS INC | COM | 50212V100 |  | 501110 | 1403 | SH |  | SOLE | 0 | 1403 | 0 | 0 |
| MAPLIGHT THERAPEUTICS INC | COM | 56565P103 |  | 301047 | 17139 | SH |  | SOLE | 0 | 17139 | 0 | 0 |
| NORTHEAST BK PORTLAND ME | COM | 66405S100 |  | 1215046 | 11691 | SH |  | SOLE | 0 | 11691 | 0 | 0 |
| NORTHPOINTE BANCSHARES INC. | COM SHS | 66661N886 |  | 313971 | 18711 | SH |  | SOLE | 0 | 18711 | 0 | 0 |
| MAPLIGHT THERAPEUTICS INC | COM | 56565P103 |  | 81273 | 4627 | SH |  | SOLE | 0 | 4627 | 0 | 0 |
| MINERALYS THERAPEUTICS INC | COM | 603170101 |  | 243107 | 6699 | SH |  | SOLE | 0 | 6699 | 0 | 0 |
| MINERALYS THERAPEUTICS INC | COM | 603170101 |  | 26020 | 717 | SH |  | SOLE | 0 | 717 | 0 | 0 |
| MONTE ROSA THERAPEUTICS INC | COM | 61225M102 |  | 261809 | 16697 | SH |  | SOLE | 0 | 16697 | 0 | 0 |
| MONTE ROSA THERAPEUTICS INC | COM | 61225M102 |  | 86460 | 5514 | SH |  | SOLE | 0 | 5514 | 0 | 0 |
| PALISADE BIO INC | COM | 696389402 |  | 104671 | 44541 | SH |  | SOLE | 0 | 44541 | 0 | 0 |
| PALISADE BIO INC | COM | 696389402 |  | 873011 | 371494 | SH |  | SOLE | 0 | 371494 | 0 | 0 |
| PDD HOLDINGS INC | SPONSORED ADS | 722304102 |  | 654034 | 5768 | SH |  | SOLE | 0 | 5768 | 0 | 0 |
| PDD HOLDINGS INC | SPONSORED ADS | 722304102 |  | 1208170 | 10655 | SH |  | SOLE | 0 | 10655 | 0 | 0 |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 |  | 532774 | 6100 | SH |  | SOLE | 0 | 6100 | 0 | 0 |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 |  | 157911 | 1808 | SH |  | SOLE | 0 | 1808 | 0 | 0 |
| RELMADA THERAPEUTICS INC | COM | 75955J402 |  | 502426 | 104022 | SH |  | SOLE | 0 | 104022 | 0 | 0 |
| RELMADA THERAPEUTICS INC | COM | 75955J402 |  | 613898 | 127101 | SH |  | SOLE | 0 | 127101 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 795704 | 9990 | SH |  | SOLE | 0 | 9990 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 601119 | 7547 | SH |  | SOLE | 0 | 7547 | 0 | 0 |
| TERNS PHARMACEUTICALS INC | COM | 880881107 |  | 3687833 | 91283 | SH |  | SOLE | 0 | 91283 | 0 | 0 |
| TERNS PHARMACEUTICALS INC | COM | 880881107 |  | 899789 | 22272 | SH |  | SOLE | 0 | 22272 | 0 | 0 |
| TREVI THERAPEUTICS INC | COM | 89532M101 |  | 327060 | 26123 | SH |  | SOLE | 0 | 26123 | 0 | 0 |
| TREVI THERAPEUTICS INC | COM | 89532M101 |  | 246732 | 19707 | SH |  | SOLE | 0 | 19707 | 0 | 0 |
| UNITED THERAPEUTICS CORP DEL | COM | 91307C102 |  | 1294136 | 2656 | SH |  | SOLE | 0 | 2656 | 0 | 0 |
| UNITED THERAPEUTICS CORP DEL | COM | 91307C102 |  | 297710 | 611 | SH |  | SOLE | 0 | 611 | 0 | 0 |
| UPSTREAM BIO INC | COM | 91678A107 |  | 149189 | 5495 | SH |  | SOLE | 0 | 5495 | 0 | 0 |
| UPSTREAM BIO INC | COM | 91678A107 |  | 92636 | 3412 | SH |  | SOLE | 0 | 3412 | 0 | 0 |
| VIR BIOTECHNOLOGY INC | COM | 92764N102 |  | 160760 | 26660 | SH |  | SOLE | 0 | 26660 | 0 | 0 |
| VIR BIOTECHNOLOGY INC | COM | 92764N102 |  | 222447 | 36890 | SH |  | SOLE | 0 | 36890 | 0 | 0 |
| UROGEN PHARMA LTD | COM | M96088105 |  | 136398 | 5824 | SH |  | SOLE | 0 | 5824 | 0 | 0 |
| UROGEN PHARMA LTD | COM | M96088105 |  | 163518 | 6982 | SH |  | SOLE | 0 | 6982 | 0 | 0 |
| BW LPG LTD | COM | Y10230103 |  | 314141 | 24000 | SH |  | SOLE | 0 | 24000 | 0 | 0 |
| BW LPG LTD | COM | Y10230103 |  | 254114 | 19398 | SH |  | SOLE | 0 | 19398 | 0 | 0 |
| PATHWARD FINANCIAL INC | COM | 59100U108 |  | 730377 | 10287 | SH |  | SOLE | 0 | 10287 | 0 | 0 |
| PENNYMAC FINL SVCS INC NEW | COM | 70932M107 |  | 308374 | 2339 | SH |  | SOLE | 0 | 2339 | 0 | 0 |
| QCR HOLDINGS INC | COM | 74727A104 |  | 701219 | 8418 | SH |  | SOLE | 0 | 8418 | 0 | 0 |
| SEACOAST BKG CORP FLA | COM NEW | 811707801 |  | 514440 | 16373 | SH |  | SOLE | 0 | 16373 | 0 | 0 |
| SOUTHSTATE BK CORP | COM | 84472E102 |  | 660276 | 7016 | SH |  | SOLE | 0 | 7016 | 0 | 0 |
| SPROTT INC | COM NEW | 852066208 |  | 686811 | 7014 | SH |  | SOLE | 0 | 7014 | 0 | 0 |
| STIFEL FINL CORP | COM | 860630102 |  | 1405845 | 11227 | SH |  | SOLE | 0 | 11227 | 0 | 0 |
| TRUIST FINL CORP | COM | 89832Q109 |  | 920719 | 18710 | SH |  | SOLE | 0 | 18710 | 0 | 0 |
| AARDVARK THERAPEUTICS INC | COM | 002942100 |  | 55532 | 4231 | SH |  | SOLE | 0 | 4231 | 0 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 |  | 569832 | 1433 | SH |  | SOLE | 0 | 1433 | 0 | 0 |
| ANI PHARMACEUTICALS INC | COM | 00182C103 |  | 1130421 | 14320 | SH |  | SOLE | 0 | 14320 | 0 | 0 |
| ANNEXON INC | COM | 03589W102 |  | 470158 | 93657 | SH |  | SOLE | 0 | 93657 | 0 | 0 |
| ARDELYX INC | COM | 039697107 |  | 352657 | 60490 | SH |  | SOLE | 0 | 60490 | 0 | 0 |
| ASCENDIS PHARMA A/S | SPONSORED ADR | 04351P101 |  | 390656 | 1832 | SH |  | SOLE | 0 | 1832 | 0 | 0 |
| AYTU BIOPHARMA INC | COM | 054754858 |  | 206479 | 79415 | SH |  | SOLE | 0 | 79415 | 0 | 0 |
| BEONE MEDICINES LTD | SPONSORED ADS | 07725L102 |  | 607316 | 1999 | SH |  | SOLE | 0 | 1999 | 0 | 0 |
| BIOAGE LABS INC | COM | 09077V100 |  | 962800 | 72774 | SH |  | SOLE | 0 | 72774 | 0 | 0 |
| BIOCRYST PHARMACEUTICALS INC | COM | 09058V103 |  | 403268 | 51701 | SH |  | SOLE | 0 | 51701 | 0 | 0 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 |  | 2325793 | 39135 | SH |  | SOLE | 0 | 39135 | 0 | 0 |
| BRIDGEBIO PHARMA INC | COM | 10806X102 |  | 1430057 | 18696 | SH |  | SOLE | 0 | 18696 | 0 | 0 |
| CONNECT BIOPHARMA HLDGS LTD | SHS | G23549101 |  | 75503 | 26774 | SH |  | SOLE | 0 | 26774 | 0 | 0 |
| CORCEPT THERAPEUTICS INC | COM | 218352102 |  | 898954 | 25832 | SH |  | SOLE | 0 | 25832 | 0 | 0 |
| EDESA BIOTECH INC | COM NEW | 27966L306 |  | 17493 | 12319 | SH |  | SOLE | 0 | 12319 | 0 | 0 |
| ELI LILLY  CO | COM | 532457108 |  | 572804 | 533 | SH |  | SOLE | 0 | 533 | 0 | 0 |
| ENANTA PHARMACEUTICALS INC | COM | 29251M106 |  | 275439 | 17466 | SH |  | SOLE | 0 | 17466 | 0 | 0 |
| EQUILLIUM INC | COM | 29446K106 |  | 144341 | 93123 | SH |  | SOLE | 0 | 93123 | 0 | 0 |
| INDIVIOR PLC | ORD | G4766E116 |  | 162536 | 4530 | SH |  | SOLE | 0 | 4530 | 0 | 0 |
| INHIBRX BIOSCIENCES INC | COM | 45720N103 |  | 27334 | 346 | SH |  | SOLE | 0 | 346 | 0 | 0 |
| INOVIO PHARMACEUTICALS INC | COM SHS | 45773H409 |  | 247365 | 142164 | SH |  | SOLE | 0 | 142164 | 0 | 0 |
| IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 |  | 613495 | 182046 | SH |  | SOLE | 0 | 182046 | 0 | 0 |
| JOHNSON  JOHNSON | COM | 478160104 |  | 3664671 | 17708 | SH |  | SOLE | 0 | 17708 | 0 | 0 |
| LIGAND PHARMACEUTICALS INC | COM NEW | 53220K504 |  | 149554 | 791 | SH |  | SOLE | 0 | 791 | 0 | 0 |
| MANNKIND CORP | COM NEW | 56400P706 |  | 461895 | 81463 | SH |  | SOLE | 0 | 81463 | 0 | 0 |
| NEUPHORIA THERAPEUTICS INC | COM | 64136E102 |  | 52004 | 13403 | SH |  | SOLE | 0 | 13403 | 0 | 0 |
| PACIRA BIOSCIENCES INC | COM | 695127100 |  | 335457 | 12962 | SH |  | SOLE | 0 | 12962 | 0 | 0 |
| PELTHOS THERAPEUTICS INC | COM SHS | 171126204 |  | 186217 | 6007 | SH |  | SOLE | 0 | 6007 | 0 | 0 |
| PLIANT THERAPEUTICS INC | COM | 729139105 |  | 47374 | 38831 | SH |  | SOLE | 0 | 38831 | 0 | 0 |
| PROQR THRAPEUTICS N V | SHS EURO | N71542109 |  | 91211 | 45154 | SH |  | SOLE | 0 | 45154 | 0 | 0 |
| PROTHENA CORP PLC | SHS | G72800108 |  | 273025 | 28589 | SH |  | SOLE | 0 | 28589 | 0 | 0 |
| PURETECH HEALTH PLC | ADS | 746237106 |  | 29375 | 1759 | SH |  | SOLE | 0 | 1759 | 0 | 0 |
| REGENERON PHARMACEUTICALS | COM | 75886F107 |  | 2107977 | 2731 | SH |  | SOLE | 0 | 2731 | 0 | 0 |
| REPLIMUNE GROUP INC | COM | 76029N106 |  | 597663 | 61488 | SH |  | SOLE | 0 | 61488 | 0 | 0 |
| RIGEL PHARMACEUTICALS INC | COM | 766559702 |  | 342426 | 7995 | SH |  | SOLE | 0 | 7995 | 0 | 0 |
| SOLENO THERAPEUTICS INC | COM | 834203309 |  | 343361 | 7416 | SH |  | SOLE | 0 | 7416 | 0 | 0 |
| STOKE THERAPEUTICS INC | COM | 86150R107 |  | 145242 | 4576 | SH |  | SOLE | 0 | 4576 | 0 | 0 |
| TALPHERA INC | COM NEW | 00444T209 |  | 41758 | 36630 | SH |  | SOLE | 0 | 36630 | 0 | 0 |
| TENAX THERAPEUTICS INC | COM NEW | 88032L605 |  | 795666 | 65272 | SH |  | SOLE | 0 | 65272 | 0 | 0 |
| TG THERAPEUTICS INC | COM | 88322Q108 |  | 990050 | 33212 | SH |  | SOLE | 0 | 33212 | 0 | 0 |
| UNIQURE NV | SHS | N90064101 |  | 263565 | 11014 | SH |  | SOLE | 0 | 11014 | 0 | 0 |
| VAXCYTE INC | COM | 92243G108 |  | 246111 | 5334 | SH |  | SOLE | 0 | 5334 | 0 | 0 |
| VENTYX BIOSCIENCES INC | COM | 92332V107 |  | 484387 | 53642 | SH |  | SOLE | 0 | 53642 | 0 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 |  | 1208658 | 2666 | SH |  | SOLE | 0 | 2666 | 0 | 0 |
| VIKING THERAPEUTICS INC | COM | 92686J106 |  | 3184283 | 90514 | SH |  | SOLE | 0 | 90514 | 0 | 0 |
| VIRIDIAN THERAPEUTICS INC | COM | 92790C104 |  | 176450 | 5670 | SH |  | SOLE | 0 | 5670 | 0 | 0 |
| VISTAGEN THERAPEUTICS INC | COM | 92840H400 |  | 17614 | 26612 | SH |  | SOLE | 0 | 26612 | 0 | 0 |
| XERIS BIOPHARMA HOLDINGS INC | COM | 98422E103 |  | 358031 | 45609 | SH |  | SOLE | 0 | 45609 | 0 | 0 |
| MICROSOFT CORP | COM | 594918104 |  | 567770 | 1174 | SH |  | SOLE | 0 | 1174 | 0 | 0 |
| NEW ORIENTAL ED  TECHNOLOGY | SPON ADR | 647581206 |  | 650730 | 11825 | SH |  | SOLE | 0 | 11825 | 0 | 0 |
| YATSEN HLDG LTD | SPONSORED ADS | 985194208 |  | 40191 | 10332 | SH |  | SOLE | 0 | 10332 | 0 | 0 |
| MINISO GROUP HLDG LTD | SPONSORED ADS | 66981J102 |  | 680569 | 36297 | SH |  | SOLE | 0 | 36297 | 0 | 0 |
| NIKE INC | CL B | 654106103 |  | 133791 | 2100 | SH |  | SOLE | 0 | 2100 | 0 | 0 |
| AMAZON COM INC | COM | 023135106 |  | 369312 | 1600 | SH |  | SOLE | 0 | 1600 | 0 | 0 |
| SYNOPSYS INC | COM | 871607107 |  | 1294079 | 2755 | SH |  | SOLE | 0 | 2755 | 0 | 0 |
| COHERENT CORP | COM | 19247G107 |  | 129199 | 700 | SH |  | SOLE | 0 | 700 | 0 | 0 |
| TRIP COM GROUP LTD | ADS | 89677Q107 |  | 175029 | 2434 | SH |  | SOLE | 0 | 2434 | 0 | 0 |
| HUYA INC | ADS REP SHS A | 44852D108 |  | 153518 | 53305 | SH |  | SOLE | 0 | 53305 | 0 | 0 |
| UNITY SOFTWARE INC | COM | 91332U101 |  | 297441 | 6734 | SH |  | SOLE | 0 | 6734 | 0 | 0 |
| FIRST SOLAR INC | COM | 336433107 |  | 102663 | 393 | SH |  | SOLE | 0 | 393 | 0 | 0 |
| BLOOM ENERGY CORP | COM CL A | 093712107 |  | 121385 | 1397 | SH |  | SOLE | 0 | 1397 | 0 | 0 |
| GDS HLDGS LTD | SPONSORED ADS | 36165L108 |  | 463158 | 13271 | SH |  | SOLE | 0 | 13271 | 0 | 0 |
| CENCORA INC | COM | 03073E105 |  | 377942 | 1119 | SH |  | SOLE | 0 | 1119 | 0 | 0 |
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 |  | 112333 | 8523 | SH |  | SOLE | 0 | 8523 | 0 | 0 |
| IMMIX BIOPHARMA INC | COM | 45258H106 |  | 166079 | 31755 | SH |  | SOLE | 0 | 31755 | 0 | 0 |
| ENVISTA HOLDINGS CORPORATION | COM | 29415F104 |  | 92571 | 4264 | SH |  | SOLE | 0 | 4264 | 0 | 0 |
| ZYMEWORKS INC | COM | 98985Y108 |  | 193420 | 7346 | SH |  | SOLE | 0 | 7346 | 0 | 0 |
| STRYKER CORPORATION | COM | 863667101 |  | 188388 | 536 | SH |  | SOLE | 0 | 536 | 0 | 0 |
| CHEMED CORP NEW | COM | 16359R103 |  | 144189 | 337 | SH |  | SOLE | 0 | 337 | 0 | 0 |
| SAB BIOTHERAPEUTICS INC | COM NEW | 78397T202 |  | 74015 | 19790 | SH |  | SOLE | 0 | 19790 | 0 | 0 |
| SPYRE THERAPEUTICS INC | COM NEW | 00773J202 |  | 73579 | 2246 | SH |  | SOLE | 0 | 2246 | 0 | 0 |
| IBIO INC | COM NEW | 451033708 |  | 76399 | 39585 | SH |  | SOLE | 0 | 39585 | 0 | 0 |
| AMYLYX PHARMACEUTICALS INC | COM | 03237H101 |  | 376256 | 31147 | SH |  | SOLE | 0 | 31147 | 0 | 0 |
| CONTINEUM THERAPEUTICS INC | CL A | 21217B100 |  | 158340 | 13853 | SH |  | SOLE | 0 | 13853 | 0 | 0 |
| ROIVANT SCIENCES LTD | SHS | G76279101 |  | 306426 | 14121 | SH |  | SOLE | 0 | 14121 | 0 | 0 |
| ATAI BECKLEY NV | SHS | N0731H103 |  | 179850 | 43973 | SH |  | SOLE | 0 | 43973 | 0 | 0 |
| MEDTRONIC PLC | SHS | G5960L103 |  | 481165 | 5009 | SH |  | SOLE | 0 | 5009 | 0 | 0 |
| CG ONCOLOGY INC | COM | 156944100 |  | 512481 | 12343 | SH |  | SOLE | 0 | 12343 | 0 | 0 |
| BENITEC BIOPHARMA INC | COM NEW | 08205P209 |  | 279543 | 20753 | SH |  | SOLE | 0 | 20753 | 0 | 0 |
| AVALO THERAPEUTICS INC | COM NEW | 05338F306 |  | 273980 | 15087 | SH |  | SOLE | 0 | 15087 | 0 | 0 |
| CODEXIS INC | COM | 192005106 |  | 45335 | 27813 | SH |  | SOLE | 0 | 27813 | 0 | 0 |
| DENALI THERAPEUTICS INC | COM | 24823R105 |  | 93612 | 5670 | SH |  | SOLE | 0 | 5670 | 0 | 0 |
| MIRUM PHARMACEUTICALS INC | COM | 604749101 |  | 804829 | 10189 | SH |  | SOLE | 0 | 10189 | 0 | 0 |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 |  | 67000 | 22259 | SH |  | SOLE | 0 | 22259 | 0 | 0 |
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 |  | 253667 | 11029 | SH |  | SOLE | 0 | 11029 | 0 | 0 |
| CELCUITY INC | COM | 15102K100 |  | 670153 | 6719 | SH |  | SOLE | 0 | 6719 | 0 | 0 |
| BOSTON SCIENTIFIC CORP | COM | 101137107 |  | 834122 | 8748 | SH |  | SOLE | 0 | 8748 | 0 | 0 |
| ARRIVENT BIOPHARMA INC | COM | 04272N102 |  | 160216 | 7963 | SH |  | SOLE | 0 | 7963 | 0 | 0 |
| OSCAR HEALTH INC | CL A | 687793109 |  | 272685 | 18976 | SH |  | SOLE | 0 | 18976 | 0 | 0 |
| APOGEE THERAPEUTICS INC | COM | 03770N101 |  | 184549 | 2445 | SH |  | SOLE | 0 | 2445 | 0 | 0 |
| XBIOTECH INC | COM | 98400H102 |  | 32420 | 13565 | SH |  | SOLE | 0 | 13565 | 0 | 0 |
| ROYALTY PHARMA PLC | SHS CLASS A | G7709Q104 |  | 254792 | 6594 | SH |  | SOLE | 0 | 6594 | 0 | 0 |
| PROTARA THERAPEUTICS INC | COM STK | 74365U107 |  | 57207 | 10733 | SH |  | SOLE | 0 | 10733 | 0 | 0 |
| CERTARA INC | COM | 15687V109 |  | 112689 | 12791 | SH |  | SOLE | 0 | 12791 | 0 | 0 |
| SANOFI SA | SPONSORED ADR | 80105N105 |  | 360785 | 7445 | SH |  | SOLE | 0 | 7445 | 0 | 0 |
| EDWARDS LIFESCIENCES CORP | COM | 28176E108 |  | 491125 | 5761 | SH |  | SOLE | 0 | 5761 | 0 | 0 |
| COMPASS PATHWAYS PLC | SPONSORED ADS | 20451W101 |  | 37833 | 5483 | SH |  | SOLE | 0 | 5483 | 0 | 0 |
| TENET HEALTHCARE CORP | COM NEW | 88033G407 |  | 496601 | 2499 | SH |  | SOLE | 0 | 2499 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 204218 | 3214 | SH |  | SOLE | 0 | 3214 | 0 | 0 |
| JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 |  | 321470 | 1891 | SH |  | SOLE | 0 | 1891 | 0 | 0 |
| MERCK  CO INC | COM | 58933Y105 |  | 365357 | 3471 | SH |  | SOLE | 0 | 3471 | 0 | 0 |
| PRAXIS PRECISION MEDICINES I | COM NEW | 74006W207 |  | 414699 | 1407 | SH |  | SOLE | 0 | 1407 | 0 | 0 |
| OCULAR THERAPEUTIX INC | COM | 67576A100 |  | 291166 | 23984 | SH |  | SOLE | 0 | 23984 | 0 | 0 |
| NATERA INC | COM | 632307104 |  | 339970 | 1484 | SH |  | SOLE | 0 | 1484 | 0 | 0 |
| LEXEO THERAPEUTICS INC | COM | 52886X107 |  | 159128 | 16025 | SH |  | SOLE | 0 | 16025 | 0 | 0 |
| PASITHEA THERAPEUTICS CORP | COM NEW | 70261F202 |  | 374816 | 290555 | SH |  | SOLE | 0 | 290555 | 0 | 0 |
| INSMED INC | COM PAR $.01 | 457669307 |  | 642556 | 3692 | SH |  | SOLE | 0 | 3692 | 0 | 0 |
| THERMO FISHER SCIENTIFIC INC | COM | 883556102 |  | 266547 | 460 | SH |  | SOLE | 0 | 460 | 0 | 0 |
| DIANTHUS THERAPEUTICS INC | COM | 252828108 |  | 401344 | 9739 | SH |  | SOLE | 0 | 9739 | 0 | 0 |
| ADAPTIVE BIOTECHNOLOGIES COR | COM | 00650F109 |  | 108629 | 6689 | SH |  | SOLE | 0 | 6689 | 0 | 0 |
| CORBUS PHARMACEUTICALS HLDGS | COM NEW | 21833P301 |  | 53618 | 6587 | SH |  | SOLE | 0 | 6587 | 0 | 0 |
| INHIBIKASE THERAPEUTICS INC | COM NEW | 45719W205 |  | 191532 | 93430 | SH |  | SOLE | 0 | 93430 | 0 | 0 |
| FULCRUM THERAPEUTICS INC | COM | 359616109 |  | 74816 | 6615 | SH |  | SOLE | 0 | 6615 | 0 | 0 |
| BELITE BIO INC | SPONSORED ADS | 07782B104 |  | 107653 | 673 | SH |  | SOLE | 0 | 673 | 0 | 0 |
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 |  | 154780 | 1446 | SH |  | SOLE | 0 | 1446 | 0 | 0 |
| LB PHARMACEUTICALS INC | COM SHS | 50180M108 |  | 90821 | 4080 | SH |  | SOLE | 0 | 4080 | 0 | 0 |
| DBV TECHNOLOGIES S A | SPONSORED ADS | 23306J309 |  | 115384 | 6019 | SH |  | SOLE | 0 | 6019 | 0 | 0 |
| GE HEALTHCARE TECHNOLOGIES I | COMMON STOCK | 36266G107 |  | 156822 | 1912 | SH |  | SOLE | 0 | 1912 | 0 | 0 |
| INTUITIVE SURGICAL INC | COM NEW | 46120E602 |  | 553334 | 977 | SH |  | SOLE | 0 | 977 | 0 | 0 |
| MAZE THERAPEUTICS INC | COM | 578784100 |  | 273645 | 6605 | SH |  | SOLE | 0 | 6605 | 0 | 0 |
| ZAI LAB LTD | ADR | 98887Q104 |  | 217660 | 12339 | SH |  | SOLE | 0 | 12339 | 0 | 0 |
| CIDARA THERAPEUTICS INC | COM NEW | 171757206 |  | 1039067 | 4704 | SH |  | SOLE | 0 | 4704 | 0 | 0 |
| EXAGEN INC | COM | 30068X103 |  | 80438 | 13230 | SH |  | SOLE | 0 | 13230 | 0 | 0 |
| REZOLUTE INC | COM NEW | 76200L309 |  | 171433 | 72641 | SH |  | SOLE | 0 | 72641 | 0 | 0 |
| BIOGEN INC | COM | 09062X103 |  | 505795 | 2874 | SH |  | SOLE | 0 | 2874 | 0 | 0 |
| EYEPOINT INC | COM NEW | 30233G209 |  | 98420 | 5387 | SH |  | SOLE | 0 | 5387 | 0 | 0 |
| TRAVERE THERAPEUTICS INC | COM | 89422G107 |  | 125749 | 3291 | SH |  | SOLE | 0 | 3291 | 0 | 0 |
| DENTSPLY SIRONA INC | COM | 24906P109 |  | 98355 | 8605 | SH |  | SOLE | 0 | 8605 | 0 | 0 |
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 |  | 226725 | 9069 | SH |  | SOLE | 0 | 9069 | 0 | 0 |
| NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | N62509109 |  | 138496 | 3948 | SH |  | SOLE | 0 | 3948 | 0 | 0 |
| CHARLES RIV LABS INTL INC | COM | 159864107 |  | 418709 | 2099 | SH |  | SOLE | 0 | 2099 | 0 | 0 |
| ICON PLC | SHS | G4705A100 |  | 450812 | 2474 | SH |  | SOLE | 0 | 2474 | 0 | 0 |
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 |  | 337059 | 19827 | SH |  | SOLE | 0 | 19827 | 0 | 0 |
| DISC MEDICINE INC | COM | 254604101 |  | 141350 | 1780 | SH |  | SOLE | 0 | 1780 | 0 | 0 |
| VOR BIOPHARMA INC | COM NEW | 929033207 |  | 141238 | 10798 | SH |  | SOLE | 0 | 10798 | 0 | 0 |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 |  | 169424 | 2436 | SH |  | SOLE | 0 | 2436 | 0 | 0 |
| CASTLE BIOSCIENCES INC | COM | 14843C105 |  | 95811 | 2463 | SH |  | SOLE | 0 | 2463 | 0 | 0 |
| GLAUKOS CORP | COM | 377322102 |  | 425671 | 3770 | SH |  | SOLE | 0 | 3770 | 0 | 0 |
| ARGENX SE | SPONSORED ADR | 04016X101 |  | 474296 | 564 | SH |  | SOLE | 0 | 564 | 0 | 0 |
| CLIMB BIO INC | COM | 28658R106 |  | 36912 | 9228 | SH |  | SOLE | 0 | 9228 | 0 | 0 |
| BRIDGEBIO ONCOLOGY THERAPEUT | COM NEW | 107924102 |  | 107484 | 8585 | SH |  | SOLE | 0 | 8585 | 0 | 0 |
| COMPASS THERAPEUTICS INC | COM | 20454B104 |  | 307449 | 57253 | SH |  | SOLE | 0 | 57253 | 0 | 0 |
| IONIS PHARMACEUTICALS INC | COM | 462222100 |  | 617612 | 7807 | SH |  | SOLE | 0 | 7807 | 0 | 0 |
| LIVANOVA PLC | SHS | G5509L101 |  | 240644 | 3911 | SH |  | SOLE | 0 | 3911 | 0 | 0 |
| INTEGER HLDGS CORP | COM | 45826H109 |  | 319602 | 4075 | SH |  | SOLE | 0 | 4075 | 0 | 0 |
| INVIVYD INC | COM | 00534A102 |  | 170042 | 68843 | SH |  | SOLE | 0 | 68843 | 0 | 0 |
| KARYOPHARM THERAPEUTICS INC | COM NEW | 48576U205 |  | 134806 | 18316 | SH |  | SOLE | 0 | 18316 | 0 | 0 |
| FORTE BIOSCIENCES INC | COM NEW | 34962G208 |  | 276681 | 10146 | SH |  | SOLE | 0 | 10146 | 0 | 0 |
| PHATHOM PHARMACEUTICALS INC | COM | 71722W107 |  | 214276 | 12916 | SH |  | SOLE | 0 | 12916 | 0 | 0 |
| JADE BIOSCIENCES INC | COM NEW | 008064206 |  | 192397 | 12469 | SH |  | SOLE | 0 | 12469 | 0 | 0 |
| SURROZEN INC | COM NEW | 86889P208 |  | 98513 | 4359 | SH |  | SOLE | 0 | 4359 | 0 | 0 |
| DEXCOM INC | COM | 252131107 |  | 238932 | 3600 | SH |  | SOLE | 0 | 3600 | 0 | 0 |
| SPDR GOLD TR | GOLD SHS | 78463V107 |  | 1215879 | 3068 | SH |  | SOLE | 0 | 3068 | 0 | 0 |
| BROADCOM INC | COM | 11135F101 |  | 124596 | 360 | SH |  | SOLE | 0 | 360 | 0 | 0 |
| UNITEDHEALTH GROUP INC | COM | 91324P102 |  | 913084 | 2766 | SH |  | SOLE | 0 | 2766 | 0 | 0 |
| LAM RESEARCH CORP | COM NEW | 512807306 |  | 523982 | 3061 | SH |  | SOLE | 0 | 3061 | 0 | 0 |
| MERCADOLIBRE INC | COM | 58733R102 |  | 20143 | 10 | SH |  | SOLE | 0 | 10 | 0 | 0 |
| ALPHABET INC | CAP STK CL C | 02079K107 |  | 2532052 | 8069 | SH |  | SOLE | 0 | 8069 | 0 | 0 |
| CORNING INC | COM | 219350105 |  | 461967 | 5276 | SH |  | SOLE | 0 | 5276 | 0 | 0 |
| VIKING HOLDINGS LTD | ORD SHS | G93A5A101 |  | 1054940 | 14773 | SH |  | SOLE | 0 | 14773 | 0 | 0 |
| AXT INC | COM | 00246W103 |  | 5029440 | 307611 | SH |  | SOLE | 0 | 307611 | 0 | 0 |
| APPLIED OPTOELECTRONICS INC | COM | 03823U102 |  | 236943 | 6797 | SH |  | SOLE | 0 | 6797 | 0 | 0 |
| SANDISK CORP | COM | 80004C200 |  | 4283997 | 18047 | SH |  | SOLE | 0 | 18047 | 0 | 0 |
| TAIWAN SEMICONDUCTOR MFG LTD | SPONSORED ADS | 874039100 |  | 486224 | 1600 | SH |  | SOLE | 0 | 1600 | 0 | 0 |
| ROBINHOOD MKTS INC | COM CL A | 770700102 |  | 748609 | 6619 | SH |  | SOLE | 0 | 6619 | 0 | 0 |
| JOYY INC | ADS REPSTG COM A | 46591M109 |  | 737811 | 11393 | SH |  | SOLE | 0 | 11393 | 0 | 0 |
| MODINE MFG CO | COM | 607828100 |  | 498660 | 3735 | SH |  | SOLE | 0 | 3735 | 0 | 0 |
| FAIR ISAAC CORP | COM | 303250104 |  | 175824 | 104 | SH |  | SOLE | 0 | 104 | 0 | 0 |
| NVIDIA CORPORATION | COM | 67066G104 |  | 3047783 | 16342 | SH |  | SOLE | 0 | 16342 | 0 | 0 |
| MICRON TECHNOLOGY INC | COM | 595112103 |  | 1579174 | 5533 | SH |  | SOLE | 0 | 5533 | 0 | 0 |
| AXON ENTERPRISE INC | COM | 05464C101 |  | 567930 | 1000 | SH |  | SOLE | 0 | 1000 | 0 | 0 |
| BILIBILI INC | SPONS ADS REP Z | 090040106 |  | 737700 | 30000 | SH |  | SOLE | 0 | 30000 | 0 | 0 |
| HESAI GROUP | SPONSORED ADS | 428050108 |  | 453062 | 20226 | SH |  | SOLE | 0 | 20226 | 0 | 0 |
| LI AUTO INC | SPONSORED ADS | 50202M102 |  | 507900 | 30000 | SH |  | SOLE | 0 | 30000 | 0 | 0 |
| NEBIUS GROUP N.V. | SHS CLASS A | N97284108 |  | 2511150 | 30000 | SH |  | SOLE | 0 | 30000 | 0 | 0 |
| ROBLOX CORP | CL A | 771049103 |  | 1620600 | 20000 | SH |  | SOLE | 0 | 20000 | 0 | 0 |
| RUBRIK INC. | CL A | 781154109 |  | 1223680 | 16000 | SH |  | SOLE | 0 | 16000 | 0 | 0 |
| SAILPOINT INC | COM | 78781J109 |  | 1399127 | 69161 | SH |  | SOLE | 0 | 69161 | 0 | 0 |
| SEA LTD | SPONSORD ADS | 81141R100 |  | 637850 | 5000 | SH |  | SOLE | 0 | 5000 | 0 | 0 |
| SIMILARWEB LTD | SHS | M84137104 |  | 1348200 | 180000 | SH |  | SOLE | 0 | 180000 | 0 | 0 |
| TRIPADVISOR INC | COM | 896945201 |  | 1456000 | 100000 | SH |  | SOLE | 0 | 100000 | 0 | 0 |
| ISHARES ETHEREUM TR | SHS | 46438R105 |  | 896079 | 39950 | SH |  | SOLE | 0 | 39950 | 0 | 0 |
| BARCLAYS PLC | ADR | 06738E204 |  | 585350 | 23000 | SH |  | SOLE | 0 | 23000 | 0 | 0 |
| CMB.TECH NV | SHS | B38564108 |  | 530750 | 55000 | SH |  | SOLE | 0 | 55000 | 0 | 0 |
| DORIAN LPG LTD | SHS USD | Y2106R110 |  | 1098489 | 45131 | SH |  | SOLE | 0 | 45131 | 0 | 0 |
| GOLAR LNG LTD | SHS | G9456A100 |  | 1464660 | 39362 | SH |  | SOLE | 0 | 39362 | 0 | 0 |
| INTERNATIONAL SEAWAYS INC | COM | Y41053102 |  | 97100 | 2000 | SH |  | SOLE | 0 | 2000 | 0 | 0 |
| TORM PLC | SHS CL A | G89479102 |  | 598604 | 30000 | SH |  | SOLE | 0 | 30000 | 0 | 0 |
| ALPHABET INC | CALL | 02079K907 |  | 3278 | 4 | SH | Call | SOLE | 0 | 4 | 0 | 0 |

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