# EDGAR Filing Document

**Accession Number:** 0001263508
**File Stem:** 0001104659-23-021478
**Filing Date:** 2023-2
**Character Count:** 23362
**Document Hash:** d1d0d87a8300dc765a8ddaf7cb6f5521
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-23-021478.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001104659-23-021478

**CONFORMED SUBMISSION TYPE**: SC 13G

**PUBLIC DOCUMENT COUNT**: 2

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**GROUP MEMBERS**: BAKER BROS. ADVISORS (GP) LLC

**GROUP MEMBERS**: FELIX J. BAKER

**GROUP MEMBERS**: JULIAN C. BAKER

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Kymera Therapeutics, Inc.
- **CENTRAL INDEX KEY:** 0001815442
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **IRS NUMBER:** 812992166
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-91636
- **FILM NUMBER:** 23628448

**BUSINESS ADDRESS:**
- **STREET 1:** 200 ARSENAL YARDS BLVD., SUITE 230
- **CITY:** WATERTOWN
- **STATE:** MA
- **ZIP:** 02472
- **BUSINESS PHONE:** 857-285-5314

**MAIL ADDRESS:**
- **STREET 1:** 200 ARSENAL YARDS BLVD., SUITE 230
- **CITY:** WATERTOWN
- **STATE:** MA
- **ZIP:** 02472
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** BAKER BROS. ADVISORS LP
- **CENTRAL INDEX KEY:** 0001263508
- **IRS NUMBER:** 134093645
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G

**BUSINESS ADDRESS:**
- **STREET 1:** 860 WASHINGTON STREET
- **STREET 2:** 3RD FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10014
- **BUSINESS PHONE:** 2123395600

**MAIL ADDRESS:**
- **STREET 1:** 860 WASHINGTON STREET
- **STREET 2:** 3RD FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10014

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** BAKER BROS ADVISORS LLC
- **DATE OF NAME CHANGE:** 20030911

**SCHEDULE 13G**

**SECURITIES AND EXCHANGE COMMISSION<br> WASHINGTON, DC 20549**

Under the Securities Exchange Act of 1934

**(Amendment No.)\***

**Kymera Therapeutics, Inc.**

---

| |
|:---|
| (Name of Issuer)<br>**Common Stock,** **par value $0.0001 per share** |
| (Title of Class of Securities) |

---

---

| |
|:---|
| **501575104** |
| (CUSIP Number) |
| **December 31, 2022** |
| (Date of Event which Requires Filing of this Statement) |

---

**Check the appropriate box to designate the rule pursuant to which this Schedule is filed:**

⌧ **Rule 13d-1(b)**

◻ **Rule 13d-1(c)**

◻ **Rule 13d-1(d)**

**\*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.**

**The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 (the "Act") or otherwise subject to the liabilities of that section of the Act, but shall be subject to all other provisions of the Act (however, see the Notes).**

**CUSIP No. <u>501575104</u>**

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;**1** | &nbsp;&nbsp; **NAMES OF REPORTING PERSONS**<br>Baker Bros. Advisors LP | &nbsp;&nbsp; **NAMES OF REPORTING PERSONS**<br>Baker Bros. Advisors LP |
| &nbsp;&nbsp;**2** | &nbsp;&nbsp;**CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)** | &nbsp;&nbsp; **(a)** **◻**<br> **(b)** **◻** |
| &nbsp;&nbsp;**3** | &nbsp;&nbsp; **SEC USE ONLY** | &nbsp;&nbsp; **SEC USE ONLY** |
| &nbsp;&nbsp;**4** | &nbsp;&nbsp; **CITIZENSHIP OR PLACE OF ORGANIZATION**<br>Delaware | &nbsp;&nbsp; **CITIZENSHIP OR PLACE OF ORGANIZATION**<br>Delaware |

---

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp; <br> **NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH** | &nbsp;&nbsp;**5** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **SOLE VOTING POWER**<br>2,879,825 |
| &nbsp;&nbsp; <br> **NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH** | &nbsp;&nbsp;**6** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **SHARED VOTING POWER**<br>-0- |
| &nbsp;&nbsp; <br> **NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH** | &nbsp;&nbsp;**7** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **SOLE DISPOSITIVE POWER**<br>2,879,825 |
| &nbsp;&nbsp; <br> **NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH** | &nbsp;&nbsp;**8** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **SHARED DISPOSITIVE POWER**<br>-0- |

---

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;**9** | &nbsp;&nbsp; **AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON**<br>2,879,825 | &nbsp;&nbsp; **AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON**<br>2,879,825 |
| &nbsp;&nbsp;**10** | &nbsp;&nbsp; **CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES**<br> **(See Instructions)** | &nbsp;&nbsp;◻ |
| &nbsp;&nbsp;**11** | &nbsp;&nbsp; **PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9**<br>5.2% (1) | &nbsp;&nbsp; **PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9**<br>5.2% (1) |
| &nbsp;&nbsp;**12** | &nbsp;&nbsp; **TYPE OF REPORTING PERSON (See Instructions)**<br>IA, PN | &nbsp;&nbsp; **TYPE OF REPORTING PERSON (See Instructions)**<br>IA, PN |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) Based on 54,864,727 shares of Common Stock ("Common Stock") of Kymera Therapeutics, Inc. (the "Issuer") outstanding
as of October 28, 2022, as reported in the Issuer's Form 10-Q filed with the Securities and Exchange Commission ("SEC")
on November 3, 2022.

**CUSIP No. <u>501575104</u>**

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;**1** | &nbsp;&nbsp; **NAMES OF REPORTING PERSONS**<br>Baker Bros. Advisors (GP) LLC | &nbsp;&nbsp; **NAMES OF REPORTING PERSONS**<br>Baker Bros. Advisors (GP) LLC |
| &nbsp;&nbsp;**2** | &nbsp;&nbsp;**CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)** | &nbsp;&nbsp; **(a)** **◻**<br> **(b)** **◻** |
| &nbsp;&nbsp;**3** | &nbsp;&nbsp; **SEC USE ONLY** | &nbsp;&nbsp; **SEC USE ONLY** |
| &nbsp;&nbsp;**4** | &nbsp;&nbsp; **CITIZENSHIP OR PLACE OF ORGANIZATION**<br>Delaware | &nbsp;&nbsp; **CITIZENSHIP OR PLACE OF ORGANIZATION**<br>Delaware |

---

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp; <br> **NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH** | &nbsp;&nbsp;**5** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **SOLE VOTING POWER**<br>2,879,825 |
| &nbsp;&nbsp; <br> **NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH** | &nbsp;&nbsp;**6** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **SHARED VOTING POWER**<br>-0- |
| &nbsp;&nbsp; <br> **NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH** | &nbsp;&nbsp;**7** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **SOLE DISPOSITIVE POWER**<br>2,879,825 |
| &nbsp;&nbsp; <br> **NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH** | &nbsp;&nbsp;**8** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **SHARED DISPOSITIVE POWER**<br>-0- |

---

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;**9** | &nbsp;&nbsp; **AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON**<br>2,879,825 | &nbsp;&nbsp; **AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON**<br>2,879,825 |
| &nbsp;&nbsp;**10** | &nbsp;&nbsp; **CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES**<br> **(See Instructions)** | &nbsp;&nbsp;◻ |
| &nbsp;&nbsp;**11** | &nbsp;&nbsp; **PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9**<br>5.2% (1) | &nbsp;&nbsp; **PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9**<br>5.2% (1) |
| &nbsp;&nbsp;**12** | &nbsp;&nbsp; **TYPE OF REPORTING PERSON (See Instructions)**<br>HC, OO | &nbsp;&nbsp; **TYPE OF REPORTING PERSON (See Instructions)**<br>HC, OO |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) Based on 54,864,727 shares of Common Stock of the Issuer outstanding as of October 28, 2022, as reported in the Issuer's Form
10-Q filed with the SEC on November 3, 2022.

**CUSIP No. <u>501575104</u>**

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;**1** | &nbsp;&nbsp; **NAMES OF REPORTING PERSONS**<br>Felix J. Baker | &nbsp;&nbsp; **NAMES OF REPORTING PERSONS**<br>Felix J. Baker |
| &nbsp;&nbsp;**2** | &nbsp;&nbsp;**CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)** | &nbsp;&nbsp; **(a)** **◻**<br> **(b)** **◻** |
| &nbsp;&nbsp;**3** | &nbsp;&nbsp; **SEC USE ONLY** | &nbsp;&nbsp; **SEC USE ONLY** |
| &nbsp;&nbsp;**4** | &nbsp;&nbsp; **CITIZENSHIP OR PLACE OF ORGANIZATION**<br>United States | &nbsp;&nbsp; **CITIZENSHIP OR PLACE OF ORGANIZATION**<br>United States |

---

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp; <br> **NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH** | &nbsp;&nbsp;**5** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **SOLE VOTING POWER**<br>2,879,825 |
| &nbsp;&nbsp; <br> **NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH** | &nbsp;&nbsp;**6** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **SHARED VOTING POWER**<br>-0- |
| &nbsp;&nbsp; <br> **NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH** | &nbsp;&nbsp;**7** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **SOLE DISPOSITIVE POWER**<br>2,879,825 |
| &nbsp;&nbsp; <br> **NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH** | &nbsp;&nbsp;**8** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **SHARED DISPOSITIVE POWER**<br>-0- |

---

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;**9** | &nbsp;&nbsp; **AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON**<br>2,879,825 | &nbsp;&nbsp; **AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON**<br>2,879,825 |
| &nbsp;&nbsp;**10** | &nbsp;&nbsp; **CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES**<br> **(See Instructions)** | &nbsp;&nbsp;◻ |
| &nbsp;&nbsp;**11** | &nbsp;&nbsp; **PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9**<br>5.2% (1) | &nbsp;&nbsp; **PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9**<br>5.2% (1) |
| &nbsp;&nbsp;**12** | &nbsp;&nbsp; **TYPE OF REPORTING PERSON (See Instructions)**<br>IN, HC | &nbsp;&nbsp; **TYPE OF REPORTING PERSON (See Instructions)**<br>IN, HC |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) Based on 54,864,727 shares of Common Stock of the Issuer outstanding as of October 28, 2022, as reported in the Issuer's Form
10-Q filed with the SEC on November 3, 2022.

**CUSIP No. <u>501575104</u>**

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;**1** | &nbsp;&nbsp; **NAMES OF REPORTING PERSONS**<br>Julian C. Baker | &nbsp;&nbsp; **NAMES OF REPORTING PERSONS**<br>Julian C. Baker |
| &nbsp;&nbsp;**2** | &nbsp;&nbsp;**CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)** | &nbsp;&nbsp; **(a)** **◻**<br> **(b)** **◻** |
| &nbsp;&nbsp;**3** | &nbsp;&nbsp; **SEC USE ONLY** | &nbsp;&nbsp; **SEC USE ONLY** |
| &nbsp;&nbsp;**4** | &nbsp;&nbsp; **CITIZENSHIP OR PLACE OF ORGANIZATION**<br>United States | &nbsp;&nbsp; **CITIZENSHIP OR PLACE OF ORGANIZATION**<br>United States |

---

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp; <br> **NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH** | &nbsp;&nbsp;**5** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **SOLE VOTING POWER**<br>2,879,825 |
| &nbsp;&nbsp; <br> **NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH** | &nbsp;&nbsp;**6** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **SHARED VOTING POWER**<br>-0- |
| &nbsp;&nbsp; <br> **NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH** | &nbsp;&nbsp;**7** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **SOLE DISPOSITIVE POWER**<br>2,879,825 |
| &nbsp;&nbsp; <br> **NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON<br> WITH** | &nbsp;&nbsp;**8** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **SHARED DISPOSITIVE POWER**<br>-0- |

---

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;**9** | &nbsp;&nbsp; **AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON**<br>2,879,825 | &nbsp;&nbsp; **AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON**<br>2,879,825 |
| &nbsp;&nbsp;**10** | &nbsp;&nbsp; **CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES**<br> **(See Instructions)** | &nbsp;&nbsp;◻ |
| &nbsp;&nbsp;**11** | &nbsp;&nbsp; **PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9**<br>5.2% (1) | &nbsp;&nbsp; **PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9**<br>5.2% (1) |
| &nbsp;&nbsp;<br> **12** | &nbsp;&nbsp; **TYPE OF REPORTING PERSON (See Instructions)**<br>IN, HC | &nbsp;&nbsp; **TYPE OF REPORTING PERSON (See Instructions)**<br>IN, HC |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) Based on 54,864,727 shares of Common Stock of the Issuer outstanding as of October 28, 2022, as reported in the Issuer's Form
10-Q filed with the SEC on November 3, 2022.

**Schedule 13G**

---

| | |
|:---|:---|
| **Item 1(a)** | **Name of Issuer:** |
|  | Kymera Therapeutics, Inc. (the "Issuer") |

---

---

| | |
|:---|:---|
| **Item 1(b)** | **Address of Issuer's Principal Executive Offices:** |
|  | 200 Arsenal Yards Blvd., Ste. 230 |
|  | Watertown, MA 02472 |

---

---

| | |
|:---|:---|
| **Item 2(a)** | **Name of Person Filing:** |
|  | This Schedule 13G is being filed jointly by Baker Bros. Advisors LP (the "Adviser"), Baker Bros. Advisors (GP) LLC (the "Adviser GP"), Felix J. Baker and Julian C. Baker (collectively, the "Reporting Persons"). |

---

---

| | |
|:---|:---|
| **Item 2(b)** | **Address of Principal Business Office or, if None, Residence:** |
|  | The business address of each of the Reporting Persons is: |
|  | c/o Baker Bros. Advisors LP |
|  | 860 Washington Street, 3<sup>rd</sup> Floor |
|  | New York, NY 10014 |
|  | (212) 339-5690 |

---

---

| | |
|:---|:---|
| **Item 2(c)** | **Citizenship:** |
|  | The Adviser is a limited partnership organized under the laws of the State of Delaware. The Adviser GP is a limited liability company organized under the laws of the State of Delaware. The citizenship of each of Julian C. Baker and Felix J. Baker is the United States of America. |

---

---

| | |
|:---|:---|
| **Item 2(d)** | **Title of Class of Securities:** |
|  | Common Stock, par value $0.0001 per share ("Common Stock"). |

---

---

| | |
|:---|:---|
| **Item 2(e)** | **CUSIP Number:** |
|  | 501575104 |

---

---

| | |
|:---|:---|
| **Item 3** | **If this statement is filed pursuant to §§240.13d-1(b) or (c), check whether the person filing is a:** |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) ◻ Broker or dealer registered under Section 15 of the Exchange Act.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ◻ Bank as defined in section 3(a)(6) of the Exchange Act.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) ◻ Insurance company as defined in section 3(a)(19) of the Exchange Act.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) ◻ Investment company registered under section 8 of the Investment Company Act of 1940.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) ⌧ An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) ◻ An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) ⌧ A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) ◻ A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) ◻ A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(j) ◻ Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

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| | |
|:---|:---|
| **Item 4** | **Ownership:** |

---

Items 5 through 9 and 11 of each of the cover pages to this Schedule 13G are incorporated herein by reference. Set forth below is the aggregate number of shares of Common Stock directly held by each of Baker Brothers Life Sciences, L.P. ("Life Sciences") and 667, L.P. ("667", and together with Life Sciences, the "Funds") which may be deemed to be indirectly beneficially owned by the Reporting Persons, as well as Common Stock that may be acquired upon exercise of pre-funded warrants with no expiration date with an exercise price of $0.0001 per share of Common Stock ("Pre-Funded Warrants"), subject to the limitations on exercise described below.

The information set forth below is based on 54,864,727 shares of Common Stock outstanding as of October 28, 2022, as reported in the Issuer's Form 10-Q filed with the Securities and Exchange Commission on November 3, 2022. Such percentage figures are calculated in accordance with Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the "Exchange Act").

---

| | | |
|:---|:---|:---|
| Holder | Number of Shares of Common <br> Stock we own or have the right<br> to acquire within 60 days | Percent of Class<br> Outstanding |
| 667, L.P. | 236997 | 0.4% |
| Baker Brothers Life Sciences, L.P. | 2642828 | 4.8% |
| Total | 2879825 | 5.2% |

---

The Pre-Funded Warrants are only exercisable to the extent that after giving effect to or immediately prior to such exercise by the holders thereof, their affiliates and any person who are members of a Section 13(d) group with the holders or one of their affiliates would beneficially own in the aggregate, for purposes of Rule 13d-3 under the Exchange Act, no more than 4.99% of the outstanding Common Stock (the "Beneficial Ownership Limitation"). By written notice to the Issuer, the Funds may from time to time increase or decrease the Beneficial Ownership Limitation applicable to that Fund to any other percentage not in excess of 19.99%. Any such increase will not be effective until the 61st day after such notice is delivered to the Issuer. As a result of this restriction, the number of shares of Common Stock that may be issued upon exercise of the Pre-Funded Warrants by the above holders may change depending upon changes in the outstanding Common Stock.

The Adviser GP, Felix J. Baker and Julian C. Baker as managing members of the Adviser GP, and the Adviser may be deemed to be beneficial owners of securities of the Issuer directly held by the Funds.

The Adviser GP is the sole general partner of the Adviser. Pursuant to the management agreements, as amended, among the Adviser, Life Sciences and 667 and their respective general partners, the Funds' respective general partners relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held by the Funds, and thus the Adviser has complete and unlimited discretion and authority with respect to the Funds' investments and voting power over investments.

---

| | |
|:---|:---|
| **Item 5** | **Ownership of Five Percent or Less of a Class:** |

---

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following ◻. N/A

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| | |
|:---|:---|
| **Item 6** | **Ownership of More than Five Percent on Behalf of Another Person:** |

---

N/A

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| | |
|:---|:---|
| **Item 7** | **Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person:** |

---

The information in Item 4 is incorporated herein by reference.

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| | |
|:---|:---|
| **Item 8** | **Identification and Classification of Members of the Group:** |

---

N/A

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| | |
|:---|:---|
| **Item 9** | **Notice of Dissolution of Group:** |

---

N/A

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| | |
|:---|:---|
| **Item 10** | **Certification:** |

---

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

**SIGNATURE**

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

February 14, 2023

---

| | |
|:---|:---|
| **BAKER BROS. ADVISORS LP**<br>By: Baker Bros. Advisors (GP) LLC, its general partner | **BAKER BROS. ADVISORS LP**<br>By: Baker Bros. Advisors (GP) LLC, its general partner |
| By: | /s/ Scott L. Lessing |
|  | Name: Scott L. Lessing<br> Title: President |

---

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| | |
|:---|:---|
| **BAKER BROS. ADVISORS (GP) LLC** | **BAKER BROS. ADVISORS (GP) LLC** |
| By: | /s/ Scott L. Lessing |
|  | Name: Scott L. Lessing<br> Title: President |
|  | /s/ Julian C. Baker |
|  | Julian C. Baker |
|  | /s/ Felix J. Baker |
|  | Felix J. Baker |

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## Exhibit 99.1

**EXHIBIT 99.1**

**AGREEMENT**

In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree that this Statement on Schedule 13G relating to the Common Stock of Kymera Therapeutics, Inc. is being filed with the Securities and Exchange Commission on behalf of each of them.

February 14, 2023

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| | |
|:---|:---|
| **BAKER BROS. ADVISORS LP**<br>By: Baker Bros. Advisors (GP) LLC, its general partner | **BAKER BROS. ADVISORS LP**<br>By: Baker Bros. Advisors (GP) LLC, its general partner |
| By: | /s/ Scott L. Lessing |
|  | Name: Scott L. Lessing<br> Title: President |

---

---

| | |
|:---|:---|
| **BAKER BROS. ADVISORS (GP) LLC** | **BAKER BROS. ADVISORS (GP) LLC** |
| By: | /s/ Scott L. Lessing |
|  | Name: Scott L. Lessing<br> Title: President |
|  | /s/ Julian C. Baker |
|  | Julian C. Baker |
|  | /s/ Felix J. Baker |
|  | Felix J. Baker |

---