# EDGAR Filing Document

**Accession Number:** 0001648257
**File Stem:** 0001104659-26-023831
**Filing Date:** 2026-3
**Character Count:** 295839
**Document Hash:** bf53d936a8583708a2e2a2e825aae41d
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-26-023831.hdr.sgml**: 20260305

**ACCESSION NUMBER**: 0001104659-26-023831

**CONFORMED SUBMISSION TYPE**: 6-K

**PUBLIC DOCUMENT COUNT**: 5

**CONFORMED PERIOD OF REPORT**: 20260305

**FILED AS OF DATE**: 20260305

**DATE AS OF CHANGE**: 20260305

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** HUTCHMED (China) Ltd
- **CENTRAL INDEX KEY:** 0001648257
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** E9

**FILING VALUES:**
- **FORM TYPE:** 6-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-37710
- **FILM NUMBER:** 26724227

**BUSINESS ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** 48TH FLOOR, CHEUNG KONG CENTER
- **STREET 2:** 2 QUEEN'S ROAD CENTRAL
- **CITY:** HONG KONG
- **PROVINCE COUNTRY:** K3
- **BUSINESS PHONE:** 852-2121-3888

**MAIL ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** 48TH FLOOR, CHEUNG KONG CENTER
- **STREET 2:** 2 QUEEN'S ROAD CENTRAL
- **CITY:** HONG KONG
- **PROVINCE COUNTRY:** K3

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Hutchison China MediTech Ltd
- **DATE OF NAME CHANGE:** 20150716

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**FORM 6-K**

**REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934**

**For the Month of March** **2026**

**Commission File Number: 001-37710**

**HUTCHMED (CHINA) LIMITED**

(Translation of registrant's name into English)

**48th Floor, Cheung Kong Center, 2 Queen's Road Central, Hong Kong**

(Address of principal executive offices)

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.

Form 20-F ⌧ Form 40-F □

**HUTCHMED (CHINA) LIMITED**

**Form 6-K**

<u>EXHIBIT INDEX</u>

---

| | |
|:---|:---|
| **Exhibit No.** | **Description** |
| [Exhibit 99.1](tm2525075d2_ex99-1.htm) | [Announcement relating to final results for the year ended December 31, 2025](tm2525075d2_ex99-1.htm) |
| [Exhibit 99.2](tm2525075d2_ex99-2.htm) | [HUTCHMED (China) Limited supplemental disclosures](tm2525075d2_ex99-2.htm) |

---

**SIGNATURE**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

---

| | |
|:---|:---|
| HUTCHMED (CHINA) LIMITED | HUTCHMED (CHINA) LIMITED |
| By: | /s/ Johnny Cheng |
| Name: | Johnny Cheng |
| Title: | Chief Financial Officer |

---

Date: March 5, 2026

## Exhibit 99.1

**Exhibit 99.1**

![](tm2525075d2_ex99-1img01.jpg)

**HUTCHMED Reports 2025 Full Year Results and Business Updates**

*— Geographic expansion driving ex-China sales growth; indication expansions driving China sales growth —*

*— $457 million net income, driven by profitable core operations and non-core disposal —*

*— Rapidly progressing groundbreaking ATTC technology, a source of novel drug candidates with broad therapeutic potential —*

*— Pursuing potential opportunities for partnering ATTC candidates with multinational pharmaceutical companies —*

**Hong Kong, Shanghai & Florham Park, NJ — Thursday, March 5, 2026:** HUTCHMED (China) Limited ("<u>HUTCHMED</u>", the "Company" or "we") (Nasdaq/AIM:HCM; HKEX:13) today reports its financial results for the year ended December 31, 2025 and provides updates on key clinical and commercial developments.

**HUTCHMED to host results webcasts** *at 8:00 a.m. EST / 1:00 p.m. GMT / 9:00 p.m. HKT* **in English on Thursday***, March 5, 2026, and tomorrow at 8:30 a.m. HKT* **in Chinese (Putonghua) on Friday***, March 6, 2026. After registration, investors may access the live webcast at <u>www.hutch-med.com/event</u>.*

*All amounts are expressed in US dollars unless otherwise stated. A glossary of abbreviations is on page 29.*

***Global commercial progress, delivery of sustainable growth and robust balance sheet***

· **FRUZAQLA** <sup>®</sup> **(fruquintinib ex-China) in-market sales by Takeda were up 26% to $366.2 million** (2024:
 $290.6m), propelled by successful launches, and additional reimbursement coverage, driven
 by need for novel non-chemotherapy treatments in CRC and ongoing positive experiences of
 oncologists in 3L+.

· **ELUNATE** <sup>®</sup> **(fruquintinib in China) in-market sales were $100.1 million** (2024: $115.0m), with
 strong growth in H2 (H2 up 33% vs. H1).

· **ORPATHYS** <sup>®</sup> **(savolitinib) triggered an $11.0 million milestone** payment from AstraZeneca for securing
 China approval for its third lung cancer indication.

· **Net income attributable to HUTCHMED of $456.9 million** (2024: $37.7m), with a **cash balance of $1.4 billion** at year end, boosted by a $415.8 million divestment gain net of tax.

***Antibody-Targeted Therapy Conjugate ("ATTC") platform advances into clinical trials, paving the way for a rich pipeline of new drug candidates entering the clinic***

· **Initiated first clinical trial on first ATTC** drug candidate HMPL-A251 in December 2025, quickly
 following its pre-clinical data presentation at AACR-NCI-EORTC Conference in October 2025.

· **Next ATTC drug candidates entered clinical trials**, with the HMPL-A580 trial initiated in March
 2026, and the third candidate HMPL-A830 aiming to begin Phase I by year end.

· **Pursuing potential opportunities for partnering** ATTC drug candidates with multinational pharmaceutical
 companies in 2026.

***Pipeline progress as planned across late-stage clinical portfolio***

· **Positive FRUSICA-2 Phase III (leading to NMPA sNDA acceptance) and PDAC Phase II results** presented
 at ESMO and ESMO Asia. ELUNATE<sup>®</sup> with sintilimab in 2L kidney cancer achieved
 mPFS of 22.2 vs. 6.9 months with axitinib/everolimus. SULANDA<sup>®</sup>-based combination
 in 1L metastatic PDAC also showed significant mPFS improvement and an OS benefit trend (data
 immature), leading to Phase III initiation.

· **Positive ESLIM-02 Phase III wAIHA** results for sovleplenib meeting primary endpoint of durable
 response rate within 24 weeks. **ITP NDA was accepted by the NMPA in February 2026 and wAIHA filing is planned** in H1 2026. **ESLIM-01 updated results** at ASH showed
 maximum duration of response of 25.9 weeks with median duration of exposure of around 20
 months under a tolerable safety profile. According to IQVIA, ITP has 41,000 new patients
 every year, on top of another 430,000 existing patients, while wAIHA adds another 26,000
 per year in China.

· **SACHI China and SAVANNAH global lung cancer trials of ORPATHYS<sup>®</sup>** combined with
 TAGRISSO<sup>®</sup> presented at ASCO and ELCC conferences, with the data supporting **approvals in China and Switzerland**, respectively. Enrollments completed for **SAFFRON global** and **SANOVO China** Phase III trials with readouts expected within next 12
 months.

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![](tm2525075d2_ex99-1img02.jpg)

**Dr Dan Eldar, Non-executive Chairman of HUTCHMED, said**, "Our team's expertise in the science of creating novel medicines, enhanced by advanced AI tools, positions HUTCHMED as a leader in advancing new modalities. Leveraging this leadership, we actively continue to explore new technologies, assets and targets to complement our portfolio, ready to make good use of our strong balance sheet.

Our Business Development team has encountered interest from multinational pharmaceutical companies to cooperate on the development and launch of novel drug candidates with potential to become global market leaders. Any such potential partnerships would further validate the scientific and commercial value of our new platforms, whilst allowing HUTCHMED to leverage the multinational partners' advantages regarding global development and marketing expertise to accelerate its novel medicines to address large unmet needs around the world. This strategy has been successfully demonstrated with FRUZAQLA<sup>®</sup> and will be applied to our ATTC technology, which is expected to bear its first fruits this year.

Our company is at a pivotal point. We have repositioned our commercial team to better meet challenges in our environment and to spur sales growth in China, delivering significant improvements from the second quarter of 2025. With late-stage programs, we have demonstrated impressive clinical results in Phase III trials leading to NDA filings, and we have proven experience in gaining approval with major regulatory authorities. Moreover, our large molecule technology platforms have graduated from novel drug discovery into clinical development, with two such drug candidates so far. We see this as a golden opportunity for HUTCHMED to not just work alongside with world leaders in the field, but also to increase our R&D investment and expedite the broad therapeutic potential of our platforms."

**Mr Johnny Cheng, Acting Chief Executive Officer and Chief Financial Officer of HUTCHMED, said,** "2025 has been challenging and we have implemented changes to adjust dynamically our commercial operations. Our sales team has been streamlined and is now well positioned to support growth of our key drugs, with improving sales during the second half of the year. This is all part of ensuring we have a sustainable operation that is ready for the future, where strong earnings from our commercial products drive the development of an exciting pipeline. Our next wave of products, such as sovleplenib and fanregratinib, are currently under regulatory review, strengthening sales and earnings visibility of next few years. Our strong balance sheet with $1.4 billion in cash helps support expeditious development of our ATTC technology platform and its novel drug candidates. 2025 was the third consecutive year of profits for HUTCHMED and we aim to remain financially self-sufficient in discovering and developing more innovative assets into clinical phase."

**Dr Weiguo Su, Chief Executive Officer (currently on leave of absence) and Chief Scientific Officer of HUTCHMED, said,** "We are in a new era of innovative drug development where both speed and quality are more crucial than ever. The HUTCHMED team has consistently risen to this challenge and the past year has been no exception. The late-stage clinical pipeline continues to progress and excite us, whilst our prolific drug discovery engine also continues at pace. We are particularly enthusiastic about the potential of our ATTC platform, originated by our scientists to combine the potency of small-molecule targeted therapy with the selectivity of antibodies. This approach leverages our over 20 years of hard work developing novel, efficacious medicines with better safety profiles, allowing optimum dosing and duration of treatment. We presented preclinical data on our first ATTC candidate at a major conference in October, obtained IND approval in China and the US in November, and dosed our first patient in December. Our team is well equipped with deep knowledge in drug development and experience in gaining approval for quality products around the world."

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![](tm2525075d2_ex99-1img02.jpg)

**2025 Full Year Results & Business Updates**

**I. COMMERCIAL OPERATIONS**

Total in-market sales, including FRUZAQLA<sup>®</sup>, ELUNATE<sup>®</sup>, SULANDA<sup>®</sup> and ORPATHYS<sup>®</sup>, of $524.7 million achieved growth in 2025 of 5% despite regulatory and commercial headwinds in the first half of 2025. Our performance in the second half of 2025 represents a significant inflection point with 24% growth of in-market sales compared to first half of 2025 as we begin to see the benefits of repositioning our commercial team to support continued growth.

**FRUZAQLA**<sup>®</sup> **in-market sales by Takeda were up 26% in 2025** at $366.2 million, driven by strong growth following approvals in 38 countries to date, including over 15 in 2025. Recent growth was primarily due to continued launches across Europe, Asia and the Americas (late 2025 launches included Portugal, Belgium, South Korea and Mexico), as it addresses a need for new colorectal cancer treatments. Subsequent reimbursement is also progressing, with availability to date in almost 20 countries, which led to strong uptake, most recently seen following the UK NICE recommendation. The increase was partially offset by the sales impact of the US Medicare Part D Redesign that affected many prescription medicines in 2025. FRUZAQLA<sup>®</sup> stands out with its overall safety profile and low pill burden, alongside attractive efficacy data.

Total consolidated revenue for oncology products decreased 21% to $214.4 million as compared to 2024, primarily due to a $20 million commercial milestone payment from Takeda recognized in 2024 and lower sales in China for ELUNATE<sup>®</sup>, SULANDA<sup>®</sup>, and ORPATHYS<sup>®</sup> due to the aforementioned headwinds. As with in-market sales, oncology product revenue in China have reached a similar inflection point with sales growth of 23% in the second half of 2025 compared to the first half.

Other Oncology/Immunology revenue, consisting of upfront, regulatory milestones, R&D services and licensing revenue was $71.1 million. Other Ventures revenue, mainly from prescription drug distribution, remained flat at $263.0 million, leading to total consolidated revenue of $548.5 million.

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| ($ in millions) | **In-market Sales\*** | **In-market Sales\*** | **In-market Sales\*** | **In-market Sales\*** | **Consolidated Revenue\*\*** | **Consolidated Revenue\*\*** | **Consolidated Revenue\*\*** | **Consolidated Revenue\*\*** |
|  | **2025** | **2024** | **% Change** | **(CER)** | **2025** | **2024** | **% Change** | **(CER)** |
| FRUZAQLA<sup>®</sup> | $366.2 | $290.6 | +26% | (+26%) | $89.4 | $110.8 | -19% | (-19%) |
| ELUNATE<sup>®</sup> | $100.1 | $115.0 | -13% | (-13%) | $76.9 | $86.3 | -11% | (-11%) |
| SULANDA<sup>®</sup> | $27.0 | $49.0 | -45% | (-45%) | $27.0 | $49.0 | -45% | (-45%) |
| ORPATHYS<sup>®</sup> | $28.9 | $45.5 | -36% | (-36%) | $18.6 | $24.5 | -24% | (-24%) |
| TAZVERIK<sup>®</sup> | $2.5 | $0.9 | +158% | (+156%) | $2.5 | $0.9 | +158% | (+156%) |
| &nbsp;&nbsp;**Oncology Products** | **$524.7** | **$501.0** | **+5%** | **(+5%)** | **$214.4** | **$271.5** | **-21%** | **(-21%)** |
| Takeda upfront, regulatory milestones and R&D services | Takeda upfront, regulatory milestones and R&D services | Takeda upfront, regulatory milestones and R&D services | Takeda upfront, regulatory milestones and R&D services |  | $51.6 | $67.0 | -23% | (-23%) |
| Other revenue (R&D services and licensing) | Other revenue (R&D services and licensing) | Other revenue (R&D services and licensing) | Other revenue (R&D services and licensing) |  | $19.5 | $24.9 | -21% | (-21%) |
| &nbsp;&nbsp;**Total Oncology/Immunology** |  |  |  |  | **$285.5** | **$363.4** | **-21%** | **(-21%)** |
| Other Ventures |  |  |  |  | $263.0 | $266.8 | -1% | (-1%) |
| &nbsp;&nbsp;**Total Revenue** |  |  |  |  | **$548.5** | **$630.2** | **-13%** | **(-13%)** |

---

*\* FRUZAQLA<sup>®</sup>, ELUNATE<sup>®</sup> and ORPATHYS<sup>®</sup> mainly represent total sales to third parties as provided by Takeda, Eli Lilly and AstraZeneca, respectively. \*\* FRUZAQLA<sup>®</sup> represents manufacturing revenue , royalties and commercial milestone paid by Takeda to HUTCHMED; ELUNATE<sup>®</sup> represents manufacturing revenue, promotion and marketing services revenue and royalties paid by Eli Lilly to HUTCHMED, and sales to other third parties invoiced by HUTCHMED; ORPATHYS<sup>®</sup> represents manufacturing revenue and royalties paid by AstraZeneca to HUTCHMED and sales to other third parties invoiced by HUTCHMED; SULANDA<sup>®</sup> and TAZVERIK<sup>®</sup> represent HUTCHMED's sales of the products to third parties.*

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**II. 2025 REGULATORY UPDATES**

· **Savolitinib MAA approved (temporary authorization) by Swissmedic** combined with TAGRISSO<sup>®</sup>
 for 2L EGFRm NSCLC with MET amplification and/or overexpression in February 2026.

· **Savolitinib sNDA accepted by NMPA** with priority review for 3L GC with MET amplification in December.

· **Savolitinib sNDA approved by NMPA** combined with TAGRISSO<sup>®</sup> for 2L EGFRm NSCLC with
 MET amplification in June, triggering $11.0 million milestone from AstraZeneca.

· **Savolitinib sNDA approved by NMPA** for 1L and 2L (converted from conditional to full approval) METex14
 NSCLC in January, and **approved in Hong Kong** for under the 1+ Mechanism in February.

· **Fanregratinib NDA accepted by NMPA** with priority review in 2L IHCC in December.

· **Fruquintinib sNDA accepted by NMPA** combined with sintilimab for 2L renal cell carcinoma in June.

· **Tazemetostat NDA conditionally approved by NMPA** for 3L R/R follicular lymphoma with EZH2 mutation
 in March.

**III. LATE-STAGE CLINICAL DEVELOPMENT ACTIVITIES**

***Savolitinib (ORPATHYS*** ***<sup>®</sup> in China)****, a highly selective oral inhibitor of MET*

· **Published SACHI China Phase III results in The Lancet** after presentation at ASCO 2025 for 2L EGFRm
 NSCLC patients with MET amplification, in combination with TAGRISSO<sup>®</sup>, showing
 mPFS of 8.2 months compared to 4.5 months with chemotherapy in ITT population (HR 0.34),
 and 6.9 months compared to 3.0 months in post third-generation EGFR TKI-treated subgroup
 (HR 0.32, both p<0.0001) (NCT05015608).

· **Presented SAVANNAH global Phase II** results at ELCC 2025 for 2L EGFRm NSCLC patients with MET amplification
 or overexpression, in combination with TAGRISSO<sup>®</sup>, showing ORR of 56%, mPFS
 of 7.4 months and mDoR of 7.1 months (NCT03778229).

· **Completed enrollment of SAFFRON** global Phase III study for 2L EGFRm NSCLC patients with MET amplification
 or overexpression (NCT05261399); and **completed enrollment of SANOVO** China Phase III
 study for 1L EGFRm NSCLC patients with MET overexpression (NCT05009836).

&nbsp;&nbsp;&nbsp;&nbsp;▪ SAFFRON
 topline results expected in H2 2026, which could support global filings.

&nbsp;&nbsp;&nbsp;&nbsp;▪ SANOVO
 topline results expected in late 2026 or early 2027.

· **Achieved positive data in Phase II 3L gastric cancer** registration cohort for MET-amplified
 patients, supporting the China NDA (NCT04923932).

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***Fruquintinib (ELUNATE*** ***<sup>®</sup> in China, FRUZAQLA<sup>®</sup> outside of China)****, a highly selective oral inhibitor of VEGFR*

· **Presented FRUSICA-2 registration Phase III** results at ESMO 2025 for 2L RCC, in combination with
 TYVYT<sup>®</sup> achieving mPFS of 22.2 months versus 6.9 months with axitinib/everolimus
 (HR 0.373; p<0.0001), and ORR of 60.5% vs 24.3%, with mDoR of 23.7 vs 11.3 months
 (NCT05522231).

***Sovleplenib (HMPL-523)****, an investigative and highly selective oral inhibitor of Syk*

· **Achieved positive results in Phase III part of ESLIM-02 trial for warm AIHA** in China in January 2026,
 having met its primary endpoint of durable response rate within 24 weeks of treatment. A
 sNDA submission to the NMPA is planned in the first half of 2026 (NCT05535933).

· **Resubmitted NDA for ESLIM-01 ITP** with additional stability studies in February 2026, to meet
 NMPA stipulation of a lower impurity limit. Rolling data planned to be submitted in the second
 half of 2026. The company is pursuing potential partnership to continue overseas development.

***Surufatinib (SULANDA*** ***<sup>®</sup> in China)****, an oral inhibitor of VEGFR, FGFR and CSF-1R*

· **Presented Phase II** part results of a China Phase II/III for 1L metastatic PDAC patients at ESMO
 Asia, combined with camrelizumab, nab-paclitaxel and gemcitabine, achieving mPFS of 7.2 months
 vs 5.5 months with nab-paclitaxel and gemcitabine alone (HR 0.499; p=0.0407), and ORR of
 67.7% vs 41.9%. **Initiated Phase III** part in December 2025 (NCT06361888).

***Tazemetostat (TAZVERIK*** ***<sup>®</sup> in China)****, a first-in-class, oral inhibitor of EZH2*

· **Continued enrolling SYMPHONY-1 China portion of the Phase III** portion of the global study, in combination
 with lenalidomide and rituximab, in 2L follicular lymphoma patients (NCT04224493).

***Fanregratinib (HMPL-453)****, a novel, highly selective and potent inhibitor targeting FGFR 1, 2 and 3*

· **Positive Phase II registration study data supporting NDA** accepted by the NMPA with priority review
 for IHCC with FGFR2 fusion/rearrangement in December 2025 (NCT04353375).

**IV. ANTIBODY-DRUG CONJUGATES RESEARCH & DEVELOPMENT**

HUTCHMED has developed its comprehensive **Antibody-targeted therapy conjugates (ATTCs) platform**, next-generation solutions for small-molecule inhibitor payloads conjugated to monoclonal antibodies to deliver dual mechanisms of action, designed to meet critical medical needs. Each unique payload has broad potential to lead to a family of antibody conjugate drug candidates from this platform.

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***HMPL-A251, a first-in-class PI3K/PIKK-HER2 ATTC*** *comprising of a highly selective and potent PI3K/PIKK inhibitor payload linked to a humanized anti-HER2 IgG1 antibody, via a cleavable linker*

· **First ATTC drug candidate, based on our PI3K/PIKK inhibitor payload** to address the significant
 challenges faced in targeting this pathway, including on-target toxicities that restrict
 dosing and feedback loops that enable pathway reactivation. PI3K/PIKK inhibitor payload ATTCs
 are designed to enhance targeted delivery directly to tumor cells, maximizing therapeutic
 benefit while minimizing systemic exposure.

· **Presented preclinical data at AACR-NCI-EORTC** in October 2025, showing robust antitumor activity
 with synergistic and bystander killing effects, including compared to co-administration of
 antibody and payload.

· **Initiated global Phase I/IIa trial** in December 2025, evaluating HMPL-A251 in adult patients
 with unresectable, advanced or metastatic HER2-expressing solid tumors, with sites in the
 US and China.

***HMPL-A580, a first-in-class PI3K/PIKK-EGFR ATTC*** *comprising of a PI3K/PIKK inhibitor payload linked to a humanized anti-EGFR IgG1 antibody, via a cleavable linker*

· **Second ATTC based on the PI3K/PIKK inhibitor payload**. EGFR is a well-recognized driver in tumor
 formation and disease progression. Modulation of the PI3K/AKT/mTOR pathway is required for
 EGFR-mediated tumorigenesis or resistance to EGFR-targeted therapy.

· **Preclinical data have shown that PAM pathway inhibition synergizes with anti-EGFR therapy** to enhance
 anti-tumor activity, and will be presented at an upcoming scientific conference.

· **Initiated global trial** in March 2026, evaluating in EGFR solid tumors, with US and China sites.

***Further preclinical progress with antibody drug conjugates***

· **Progressed ATTC drug candidate HMPL-A830**, with plans for global IND filings and clinical trial initiations
 in 2026.

**V. COLLABORATION UPDATES**

***Further progress with ImageneBio on drug candidate IMG-007, discovered by HUTCHMED***

HUTCHMED holds approximately 3.8% of ImageneBio, which has the rights to and is developing IMG-007.

· **Initiated ADAPTIVE Phase IIb trial for moderate-to-severe atopic dermatitis**, a randomized, placebo-controlled
 dose-finding study in approximately 220 patients (NCT07037901). Presented at ISDS positive
 results from the US/Canada Phase IIa study, **showing rapid onset and durable clinical activity** after four weeks, well tolerated safety profile without pyrexia or chills, and an extended
 half-life (NCT05984784).

· **Presented positive results of a US/Canada Phase IIa trial for severe alopecia areata** at ISDS, showing
 clinical signal of hair regrowth, progressive reduction in scalp hair loss without plateauing
 by week 36, partial restoration of hair keratins in the scalp, and a well-tolerated safety
 profile (NCT06060977).

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**VI. OTHER VENTURES**

· Other
 Ventures consolidated revenue, predominantly from the prescription drug distribution business
 in China, were steady at $263.0 million.

· HUTCHMED
 divested a 45.0% equity interest in SHPL for $608.5 million in cash in April 2025, retaining
 a 5.0% equity interest. As a result, HUTCHMED's share of equity in earnings of SHPL
 in 2025 decreased to $24.6 million.

· Consolidated
 net income attributable to HUTCHMED from Other Ventures decreased to $25.5 million (2024:
 $47.7m), primarily due to the equity interest disposal in SHPL.

**VII. SUSTAINABILITY**

**The 2025 Sustainability Report will be published in April 2026** alongside the 2025 Annual Report, **showcasing our achievements across 11 goals and targets**. We have initiated a new target-setting cycle, engaging with the various business units. A list of potential focus initiatives has been identified under our five sustainability pillars: Innovation, Climate Action, Human Capital, Access to Healthcare, and Ethics and Transparency. In 2026 we will develop this into a final list, including a detailed roadmap for achievement and monitoring.

In 2024 and 2025, the Company **conducted a thorough climate risks financial impact assessment**, focusing on both physical risks, particularly flood risks and heat stress; and transition risks, such as policy changes. In response to the risks and opportunities identified, we developed targeted mitigation measures to address potential damage and business interruptions. Our transition planning is integrated with the new targets planning, ensuring effective management of risks while capitalizing on the opportunities outlined in the assessments.

Throughout 2025, our sustainability initiatives garnered significant recognition, resulting in **10 prestigious awards from leading industry organizations and consistently strong performance in major ESG ratings**. Notably, we were honored as an ESG Leading Enterprise for a third consecutive year and received accolades for Leading Environmental Initiatives and Leading Social Initiatives from Bloomberg Businessweek. Our commitment is reflected in our maintained **A ratings** from both MSCI and Wind, and A- rating from Hang Seng Corporate Sustainability; our upgrade to B- Prime (**top decile rank**) from ISS; and ESG Risk rating score further reduced to 21.9 (**10<sup>th</sup> percentile**, lower is better) by Sustainalytics. Additionally, we were **included in the S&P Global Sustainability Yearbook** 2025 as one of the top industry performers. Our efforts were further validated as we ranked third in ESG Excellence in Extel's Asia Executive Team Survey, based on feedback from over 5,400 portfolio managers and analysts.

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**Financial Highlights**

***Revenue for the year ended December 31, 2025 was $*** ***548.5 million compared to $630.2 million for the year ended December 31, 2024.***

· **Oncology/Immunology consolidated revenue amounted to $285.5 million** (2024: $363.4m):

&nbsp;&nbsp;&nbsp;&nbsp;▪ **FRUZAQLA** <sup>®</sup> **revenue was $89.4 million** (2024: $110.8m), impacted primarily due to $20 million commercial
 payment recognized from Takeda in 2024. In-market sales by Takeda were $366.2 million (up
 26%) driven by strong growth following approvals in 38 countries to date, including
 over 15 in 2025.

&nbsp;&nbsp;&nbsp;&nbsp;▪ **ELUNATE** <sup>®</sup> **revenue was $76.9 million** (2024: $86.3m), which reflects our initiatives to enhance
 controls over commercial operations to align with the evolving regulatory landscape and uphold
 the highest compliance standards. We also streamlined our sales force to build a more efficient
 commercial organization and to enhance productivity. These initiatives only temporarily weighed
 on performance, with revenue growth of 29% in the second half of 2025 compared to the first
 half. This recovery was supported by refocusing on top-tier hospitals and high-potential
 provinces to maintain our leading market share position in 3L mCRC, and the contribution
 from the EMC indication that successfully broadened the addressable patient population for
 ELUNATE<sup>®</sup>.

&nbsp;&nbsp;&nbsp;&nbsp;▪ **SULANDA** <sup>®</sup> **revenue was $27.0 million** (2024: $49.0m), which reflects competition from new NRDL
 entries. In response, we have transformed our marketing strategies which allowed us to maintain
 the leading position of SULANDA<sup>®</sup> in the NET TKI market and stabilize sales
 in the second half of 2025 (H2 up 13% vs H1 2025).

&nbsp;&nbsp;&nbsp;&nbsp;▪ **ORPATHYS** <sup>®</sup> **revenue was $18.6 million** (2024: $24.5m), impacted by strong competition in the METex14
 skipping NSCLC setting. However, sales stabilized in the second half of 2025 as AstraZeneca
 continues its efforts to increase MET testing as the standard-of-care for late-stage NSCLC.

&nbsp;&nbsp;&nbsp;&nbsp;▪ **TAZVERIK** <sup>®</sup> **revenue was $2.5 million** (2024: $0.9m) with increased sales in mainland China since
 July 2025 following its approval in March 2025.

&nbsp;&nbsp;&nbsp;&nbsp;▪ **Takeda upfront, regulatory milestones and R&D services revenue were $51.6 million** (2024:
 $67.0m), due to less R&D and regulatory support services since FRUZAQLA<sup>®</sup>
 is now fully launched.

&nbsp;&nbsp;&nbsp;&nbsp;▪ **Other revenue of $19.5 million** (2024: $24.9m), includes $8.5 million (2024: $13.9m)
 cost reimbursement from partners, which decreased as trials advanced into later stage of
 development, and a regulatory milestone of $11.0 million from AstraZeneca following China
 NDA approval for SACHI.

· **Other Ventures consolidated revenue of $263.0 million** (2024: $266.8m) remained flat.

***Net Expenses for the year ended December 31, 2025 were $*** ***507.4 million compared to $592.5 million for the year ended December 31, 2024, reflecting prioritization of R&D and disciplined cost management.***

· **Cost of Revenue** was $336.3 million (2024: $348.9m), generally aligned with lower Oncology/Immunology
 revenue. Cost of revenue as a percentage of oncology product revenue remained stable at 39%
 (2024: 34%).

· **R&D Expenses** were $148.3 million (2024: $212.1m) as we complete higher costs late-stage trials
 for our assets which have led to NDA applications and approvals. As a result,
 China and US R&D spending reduced by $36.2 million and $27.6 million, respectively. Nevertheless,
 we maintain and are committed to ongoing investment in discovery to deliver sustained innovation
 and have plans to accelerate investment in the global clinical trials of our earlier-stage
 ATTC programs.

· **S&A Expenses** were $103.0 million (2024: $112.9m). The decrease was mainly due to a reduction
 in S&A expenses for oncology products which was $33.8 million or 15.8% of oncology product
 revenue (2024: $45.1m or 16.6%). This efficiency improvement highlights the successful streamlining
 of the sales force structure and the implementation of spending controls.

· **Other Items** generated net income of $80.2 million (2024: $81.4m), which mainly includes interest
 income and expense, foreign exchange, equity in earnings of SHPL and taxes.

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***Gain on divestment of SHPL, net of tax was $41*** ***5.8 million for the year ended December 31, 2025.***

***Net Income attributable to HUTCHMED for the year ended December 31, 2025 was $45*** ***6.9 million compared to $37.7 million for the year ended December 31, 2024.***

· $0.53
 basic earnings per ordinary share / $2.66 basic earnings per ADS in 2025 (2024: $0.04
 basic earnings per ordinary share / $0.22 basic earnings per ADS).

***Cash, Cash Equivalents and Short-Term Investments were $1,36*** ***7.3 million as of December 31, 2025 compared to $836.1 million as of December 31, 2024.***

· Adjusted
 Group (non-GAAP) net cash inflows excluding financing activities in 2025 were $523.3 million
 mainly due to the receipt of $608.5 million gross proceeds from the partial divestment of
 SHPL offset by a related $59.5 million capital gain tax payment; $10.0 million regulatory
 approval milestone payment; and $14.1 million in capital expenditures (2024: net cash outflow
 of $19.5m mainly due to $17.9m of capital expenditures).

· Net cash generated from financing activities in 2025 totaled $7.8 million
mainly due to $6.3 million net amount drawn from bank borrowings (2024: net cash outflow of $30.7m mainly due to purchases for equity
awards of $36.1m).

**Foreign exchange impact:** The RMB appreciated against the US dollar on average by approximately 0.4% during 2025, which has impacted consolidated financial results as highlighted.

**Use of Non-GAAP Financial Measures and Reconciliation** – References in this announcement to adjusted Group net cash flows excluding financing activities and financial measures reported at CER are based on non-GAAP financial measures. Please see the "Use of Non-GAAP Financial Measures and Reconciliation" for further information relevant to the interpretation of these financial measures and reconciliations of these financial measures to the most comparable GAAP measures, respectively.

**Financial Statements –** HUTCHMED will today file with the US Securities and Exchange Commission its Annual Report on Form 20-F.

**FINANCIAL GUIDANCE**

HUTCHMED provides full year 2026 guidance for Oncology/Immunology consolidated revenue in the range of $330 million to $450 million. This guidance reflects continued growth momentum of HUTCHMED's China commercial operations, ongoing global commercial expansion of **FRUZAQLA**<sup>®</sup>, and new partnership opportunities for novel drug candidates. HUTCHMED will leverage its strong cash resources to accelerate ATTC global development and explore investment opportunities. Shareholders and investors should note that:

· The
 Company does not provide any guarantee that the statements contained in the financial guidance
 will materialize or that the financial results contained therein will be achieved or are
 likely to be achieved; and

· The
 Company has in the past revised its financial guidance and reference should be made to announcements
 it publishes regarding any updates to the financial guidance after the publication of this
 announcement.

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**Financial Summary**

**Condensed Consolidated Balance Sheets Data**

---

| | | |
|:---|:---|:---|
| (in $'000) | **As of December 31,** | **As of December 31,** |
|  | **2025** | **2024** |
| **Assets** |  |  |
| &nbsp;&nbsp;&nbsp;Cash and cash equivalents and short-term investments | 1367275 | 836110 |
| &nbsp;&nbsp;&nbsp;Accounts receivable | 126750 | 155537 |
| &nbsp;&nbsp;&nbsp;Other current assets | 73317 | 74908 |
| &nbsp;&nbsp;&nbsp;Property, plant and equipment | 94623 | 92498 |
| &nbsp;&nbsp;&nbsp;Investment in equity investees | 10865 | 77765 |
| &nbsp;&nbsp;&nbsp;Other non-current assets | 80267 | 37378 |
| **Total assets** | **1753097** | **1274196** |
| **Liabilities and shareholders' equity** |  |  |
| &nbsp;&nbsp;&nbsp;Accounts payable | 45533 | 42521 |
| &nbsp;&nbsp;&nbsp;Other payables and accruals | 208892 | 256124 |
| &nbsp;&nbsp;&nbsp;Bank borrowings | 93160 | 82806 |
| &nbsp;&nbsp;&nbsp;Deferred revenue | 51547 | 98503 |
| &nbsp;&nbsp;&nbsp;Other liabilities | 102703 | 22389 |
| **Total liabilities** | **501835** | **502343** |
| **Company's shareholders' equity** | **1237926** | **759929** |
| Non-controlling interests | 13336 | 11924 |
| **Total liabilities and shareholders' equity** | **1753097** | **1274196** |

---

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**Condensed Consolidated Statements of Operations Data**

---

| | | |
|:---|:---|:---|
| (in $'000, except share and per share data) | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** |
| **Revenue:** |  |  |
| &nbsp;&nbsp;&nbsp;Oncology/Immunology – Marketed Products | 214356 | 271534 |
| &nbsp;&nbsp;&nbsp;Oncology/Immunology – R&D | 71183 | 91831 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Oncology/Immunology Consolidated Revenue | 285539 | 363365 |
| &nbsp;&nbsp;&nbsp;Other Ventures | 262973 | 266836 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**Total revenue** | **548512** | **630201** |
| **Operating expenses:** |  |  |
| &nbsp;&nbsp;&nbsp;Cost of revenue | (336349) | (348884) |
| &nbsp;&nbsp;&nbsp;Research and development expenses | (148295) | (212109) |
| &nbsp;&nbsp;&nbsp;Selling and administrative expenses | (103028) | (112913) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**Total operating expenses** | **(587672)** | **(673906)** |
| Gain on divestment of an equity investee | 476896 |  |
| Other income, net | 60955 | 42598 |
| **Income/(loss) before income taxes and equity in earnings of equity investees** | **498691** | **(1107)** |
| Income tax expense | (2477) | (7192) |
| Income tax expense – Divestment of an equity investee | (61133) |  |
| Equity in earnings of equity investees, net of tax | 22651 | 46469 |
| **Net income** | **457732** | **38170** |
| Less: Net income attributable to non-controlling interests | (823) | (441) |
| **Net income attributable to HUTCHMED** | **456909** | **37729** |
| **Earnings per share attributable to HUTCHMED (US$ per share)** |  |  |
| &nbsp;&nbsp;&nbsp;**– basic** | **0.53** | **0.04** |
| &nbsp;&nbsp;&nbsp;**– diluted** | **0.52** | **0.04** |
| Number of shares used in per share calculation |  |  |
| &nbsp;&nbsp;&nbsp;– basic | 858276608 | 855351683 |
| &nbsp;&nbsp;&nbsp;– diluted | 872891120 | 872829129 |
| **Earnings per ADS attributable to HUTCHMED (US$ per ADS)** |  |  |
| &nbsp;&nbsp;&nbsp;**– basic** | **2.66** | **0.22** |
| &nbsp;&nbsp;&nbsp;**– diluted** | **2.62** | **0.22** |
| Number of ADSs used in per ADS calculation |  |  |
| &nbsp;&nbsp;&nbsp;– basic | 171655322 | 171070337 |
| &nbsp;&nbsp;&nbsp;– diluted | 174578224 | 174565826 |

---

**About HUTCHMED**

HUTCHMED (Nasdaq/AIM:HCM; HKEX:13) is an innovative, commercial-stage, biopharmaceutical company. It is committed to the discovery and global development and commercialization of targeted therapies and immunotherapies for the treatment of cancer and immunological diseases. Since inception it has focused on bringing drug candidates from in-house discovery to patients around the world, with its first three medicines marketed in China, and the first of which is also approved around the world including in the US, Europe and Japan. For more information, please visit: <u>www.hutch-med.com</u> or follow us on <u>LinkedIn</u>.

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**Contacts**

---

| | |
|:---|:---|
| **Investor Enquiries** | +852 2121 8200 / ir@hutch-med.com |
| **Media Enquiries** |  |
| FTI Consulting – | +44 20 3727 1030 / HUTCHMED@fticonsulting.com |
| Ben Atwell / Tim Stamper | +44 7771 913 902 (Mobile) / +44 7779 436 698 (Mobile) |
| Brunswick – Zhou Yi | +852 9783 6894 (Mobile) / HUTCHMED@brunswickgroup.com |
| **Panmure Liberum** | *Nominated Advisor and Joint Broker* |
| Atholl Tweedie / Emma Earl / Rupert Dearden | +44 20 7886 2500 |
| **Cavendish** | *Joint Broker* |
| Geoff Nash / Nigel Birks | +44 20 7220 0500 |
| **Deutsche Numis** | *Joint Broker* |
| Freddie Barnfield / Jeffrey Wong / Duncan Monteith | +44 20 7260 1000 |

---

***References***

*Unless the context requires otherwise, references in this announcement to the "Group," the "Company," "HUTCHMED," "HUTCHMED Group," "we," "us," and "our," mean HUTCHMED (China) Limited and its subsidiaries unless otherwise stated or indicated by context.*

***Past Performance and Forward-Looking Statements***

*The performance and results of operations of the Group contained within this announcement are historical in nature, and past performance is no guarantee of future results of the Group. This announcement contains forward-looking statements within the meaning of the "safe harbor" provisions of the US Private Securities Litigation Reform Act of 1995. These forward-looking statements can be identified by words like "will," "expects," "anticipates," "future," "intends," "plans," "believes," "estimates," "pipeline," "could," "potential," "first-in-class," "best-in-class," "designed to," "objective," "guidance," "pursue," or similar terms, or by express or implied discussions regarding potential drug candidates, potential indications for drug candidates or by discussions of strategy, plans, expectations or intentions. You should not place undue reliance on these statements. Such forward-looking statements are based on the current beliefs and expectations of management regarding future events, and are subject to significant known and unknown risks and uncertainties. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those set forth in the forward-looking statements. There can be no guarantee that any of our drug candidates will be approved for sale in any market, that any approvals which have been obtained will continue to remain valid and effective in the future, or that the sales of products marketed or otherwise commercialized by HUTCHMED and/or its collaboration partners (collectively, "HUTCHMED's Products") will achieve any particular revenue or net income levels. In particular, management's expectations could be affected by, among other things: unexpected regulatory actions or delays or government regulation generally; the uncertainties inherent in research and development, including the inability to me et our key study assumptions regarding enrollment rates, timing and availability of subjects meeting a study's inclusion and exclusion criteria and funding requirements, changes to clinical protocols, unexpected adverse events or safety, quality or manufacturing issues; the delay or inability of a drug candidate to meet the primary or secondary endpoint of a study; the delay or inability of a drug candidate to obtain regulatory approval in different jurisdictions or the utilization, market acceptance and commercial success of HUTCHMED's Products after obtaining regulatory approval; discovery, development and/or commercialization of competing products and drug candidates that may be superior to, or more cost effective than, HUTCHMED's Products and drug candidates; the impact of studies (whether conducted by HUTCHMED or others and whether mandated or voluntary) or recommendations and guidelines from governmental authorities and other third parties on the commercial success of HUTCHMED's Products and drug candidates in development; the ability of HUTCHMED to manufacture and manage supply chains, including various third party services, for multiple products and drug candidates; the availability and extent of reimbursement of HUTCHMED's Products from third-party payers, including private payer healthcare and insurance programs and government insurance programs; the costs of developing, producing and selling HUTCHMED's Products; the ability to obtain additional funding when needed; the ability to obtain and maintain protection of intellectual property for HUTCHMED's Products and drug candidates; the ability of HUTCHMED to meet any of its financial projections or guidance and changes to the assumptions underlying those projections or guidance; the successful disposition of its non-core business; global trends toward health care cost containment, including ongoing pricing pressures; uncertainties regarding actual or potential legal proceedings, including, among others, actual or potential product liability litigation, litigation and investigations regarding sales and marketing practices, intellectual property disputes, and government investigations generally; and general economic and industry conditions, including uncertainties regarding the effects of the persistently weak economic and financial environment in many countries, uncertainties regarding future global exchange rates, uncertainties in global interest rates, and geopolitical relations, sanctions and tariffs. For further discussion of these and other risks, see HUTCHMED's filings with the US Securities and Exchange Commission, on AIM and on HKEX. HUTCHMED is providing the information in this announcement as of this date and does not undertake any obligation to update any forward-looking statements as a result of new information, future events or otherwise.*

*In addition, this announcement contains statistical data and estimates that HUTCHMED obtained from industry publications and reports generated by third-party market research firms. Although HUTCHMED believes that the publications, reports and surveys are reliable, HUTCHMED has not independently verified the data and cannot guarantee the accuracy or completeness of such data. You are cautioned not to give undue weight to this data. Such data involves risks and uncertainties and are subject to change based on various factors, including those discussed above.*

***Inside Information***

*This announcement contains inside information for the purposes of Article 7 of Regulation (EU) No 596/2014 (as it forms part of retained EU law as defined in the European Union (Withdrawal) Act 2018).*

***Medical Information***

*This announcement contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs including the ones under development.*

**Ends**

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**OPERATIONS REVIEW**

**Oncology/Immunology**

HUTCHMED discovers, develops, manufactures and markets targeted therapies and immunotherapies for the treatment of cancer and immunological diseases through a fully integrated team of approximately 870 scientists and staff, and an in-house oncology commercial organization of approximately 780 staff, based in Shanghai, Suzhou, Beijing and Hong Kong in China and New Jersey in the US.

Of our 13 clinical-stage drug candidates, four medicines – fruquintinib, surufatinib, savolitinib and tazemetostat – have been approved in mainland China. Fruquintinib has also been approved in or launched in 39 countries, including China, the US, EU and Japan. Savolitinib has completed enrollment in a global Phase III trial that, if positive, could support global NDA filings. A fifth drug candidate, sovleplenib, has a China NDA submitted and a second NDA in preparation. Our novel discovery and early-stage development is focused on progressing drug candidates from our ATTC next-generation platform, with the first two candidates in global Phase I development.

**RESEARCH & DEVELOPMENT**

We possess a track record of discovery, clinical development and regulatory submissions of an innovative medicine launched globally. Our strategy is to establish a long-term sustainable business, by prioritizing late-stage and registrational studies in China and partnering outside of China. We run early phase development for selected drug candidates internationally where we believe we can differentiate from a global perspective.

We plan to accelerate innovation through artificial intelligence (AI) integration, with a focus on key R&D stages to improve return on investment (ROI) and iterative learning. We plan to expedite the identification of high-potential drug candidates and reduce late-stage preclinical attrition. In the medium-term, we target faster patient recruitment through better screening and clinical trial design, leading to R&D efficiency gains.

***Antibody-Targeted Therapy Conjugate Next Generation Technology Platform***

For over three years, we have invested significant resources into this new platform, which could provide multiple drug candidates in the future. Unlike traditional toxin-based antibody-drug conjugates, the toxin-based payload is replaced with a targeted small molecule. Thus, ATTCs have potential to be administered in combination with chemotherapy or other targeted agents, which is particularly important in frontline settings.

Another benefit of such design is to further optimize the strength of the small-molecule drug, which may otherwise be limited by a narrow therapeutic window. Through a reduction of off-tumor or off-target toxicity, our platform is designed to deliver highly potent concentrations of small molecule inhibitors to target sites. This has potential to confer efficacy in a broad array of indications with high unmet needs and enable long-term usage. The first family of ATTCs are based on a novel payload that targets the PI3K/AKT/mTOR ("PAM") pathway, a critical intracellular network involved in cell growth, survival, and division. Alterations in the PAM pathway are frequently associated with poor prognosis and resistance to treatment across various cancers. However, existing PAM-targeted drugs face significant challenges, including on-target toxicities that restrict dosing, feedback loops that enable pathway reactivation, and insufficient tumor-specific delivery. HUTCHMED has designed a highly selective and potent PI3K/PIKK inhibitor linker-payload to overcome these challenges, exhibiting high selectivity, potency, and robust anti-tumor activity across a diverse panel of tumor cell lines. This could have broad potential to lead to a family of antibody conjugate drug candidates.

Preclinical data from the first ATTC candidate, HMPL-A251, was presented at AACR-NCI-EORTC in October 2025. HMPL-A251 is a first-in-class PI3K/PIKK-HER2 ATTC comprising of a PI3K/PIKK inhibitor payload linked to a humanized anti-HER2 IgG1 antibody, via a cleavable linker. HMPL-A251 demonstrated HER2-dependent antitumor activity and bystander effect, with potent inhibition of HER2-positive tumor growth regardless of PAM pathway alterations, and moderately reduced activity in HER2-low, PAM-altered lines. It exhibited a strong response in cell lines resistant to trastuzumab deruxtecan, a HER2-directed ADC. The global Phase I/IIa trial for HMPL-A251 initiated in December 2025 to evaluate it in adult patients with unresectable, advanced or metastatic HER2-expressing solid tumors. Similarly, the first clinical trial for HMPL-A580, a second ATTC based on the PI3K/PIKK inhibitor payload and linked to a humanized anti-EGFR IgG1 antibody, initiated in March 2026. Both trials have sites in both the US and China. HUTCHMED plans to advance global Phase I trials for another ATTC candidate, HMPL-A830, by year end 2026. Our ATTC programs have generated interest from multinational pharmaceutical companies. Such potential partnerships would validate the scientific and commercial value of our new platforms, and is consistent with HUTCHMED's strategy of leveraging partners with global expertise to accelerate bringing novel medicines to address large unmet needs around the world.

Below is a summary update of the clinical trial progress of our investigational drug candidates. For more details about each trial, please refer to recent scientific publications.

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**Savolitinib (ORPATHYS** **<sup>®</sup> in China)**

**Mechanism of action**: savolitinib is an oral, potent and highly selective inhibitor of MET. The MET pathway functions abnormally through amplification, overexpression and mutations. The aberrant activation of MET is correlated with tumor growth, survival, invasion, metastasis, suppression of cell death and angiogenesis. MET aberrations may contribute to drug resistance in NSCLC and CRC following anti-EGFR treatment.

**Target indications**: savolitinib was approved for METex14 NSCLC in 2021 in China, where there are 1.06 million new cases of lung cancer (226,000 in the US) in 2022, according to Globocan. About 80-85% are classified as NSCLC, with 2-3% in METex14. In June 2025, savolitinib expanded its indication to EGFRm MET amplified 2L NSCLC in combination with TAGRISSO<sup>®</sup>. In China, 30-40% of NSCLC patients are EGFRm (10-15% in the US). After 1L treatment, about 60% will develop resistance and progress to 2L, of which 1/3 are driven by MET. Separately, MET is an oncogenic driver occurring in 4-6% of GC, leading to poor prognosis. We are also developing for savolitinib in MET overexpressed 1L and 2L NSCLC and MET amplified 3L GC.

**Clinical development**: **SACHI** China Phase III was presented at ASCO in a late-breaking oral presentation, with **mPFS of 6.9 months (HR 0.32, p<0.0001)** for 2L NSCLC patients who failed prior third-generation EGFR TKI. Further sub-group analysis was published in **The Lancet** in January 2026, showing **mOS of 22.9 months (HR 0.32)** when excluding control group patients who received subsequent MET inhibitor. **SAFFRON** global Phase III trial completed patient enrollment in October 2025, with topline results expected in mid-2026. Recruitment for the **SANOVO** China Phase III study was completed in August 2025, with results expected in late-2026 or early-2027. In December 2025, the NMPA accepted our NDA with priority review for MET amplified 3L GC, supported by a single-arm, open-label China Phase II study which met primary endpoint of ORR.

---

| | | | | |
|:---|:---|:---|:---|:---|
| **Treatment** | **Name: Indication (control); NCT#** | **Endpoint** | **Phase** | **Status/Plan** |
| Savolitinib + TAGRISSO<sup>®</sup> | **SAFFRON:** 2L/3L EGFRm, TAGRISSO<sup>®</sup> refractory, MET amplified or overexpressed **NSCLC** (vs chemo); NCT05261399 | PFS | Global <br> III | **Fully enrolled** in Nov 2025. <br> Readout expected in H2 2026 |
| Savolitinib + TAGRISSO<sup>®</sup> | **SACHI:** 2L EGFRm, EGFR TKI refractory, MET amplified **NSCLC** (vs chemo); NCT05015608 | PFS | China <br> III | NMPA **approved** in Jun 2025. **Data** at ASCO 2025. mPFS 8.2 vs 4.5 months (ITT, HR 0.34), 6.9 vs 3.0 months (post third-generation, HR 0.32) all p<0.0001, mOS 22.9 vs 17.7 months (ITT, HR 0.84, data immature), G≥3 TRAE 45 vs 48% |
| Savolitinib + TAGRISSO<sup>®</sup> | **SAVANNAH:** 2L/3L EGFRm, TAGRISSO<sup>®</sup> refractory, MET amplified or overexpressed **NSCLC** (single-arm); NCT03778229 | ORR | Global <br> II | **Data** at ELCC 2025. By investigator/BICR: ORR 56/55%, mPFS 7.4/7.5 months, mDoR 7.1/9.9 months, G≥3 TEAE 57%. **Swissmedic MAA authorization** (temporary) in Feb 2026. |
| Savolitinib + TAGRISSO<sup>®</sup> | **SANOVO:** 1L EGFRm, MET over-expressed **NSCLC** (vs TAGRISSO<sup>®</sup>); NCT05009836 | PFS | China<br> III | **Fully enrolled** in Aug 2025.<br> Topline results expected in late 2026 or early 2027 |
| Savolitinib monotherapy | 1L/2L METex14 **NSCLC** <br> (single-arm); NCT04923945 | ORR | China<br> IIIb | NMPA **fully approved** in Jan 2025 (conditional 2021). **Data** at ELCC 2024 & 2025. 1L/2L: ORR 62.1/39.2%, mPFS 13.7/11.0 months, mOS 28.3/25.3 months, G≥3 TEAE 62% |
| Savolitinib monotherapy | 3L **gastric cancer** with MET amplified, two stages (single-arm); NCT04923932 | ORR | China<br> II | **NDA accepted by the NMPA** in Dec 2025. <br> Met primary endpoint of ORR |
| Savolitinib + IMFINZI<sup>®</sup> | **SAMETA:** MET-driven **PRCC** (vs sunitinib); NCT05043090 | PFS | Global<br> III | Did not meet primary endpoint Mar 2026 |

---

**Commercial achievement**: Savolitinib in combination with TAGRISSO<sup>®</sup> NMPA was approved in June 2025. Savolitinib is included in the NRDL for NSCLC with MET exon 14 skipping alterations.

---

| | |
|:---|:---|
| **Year** | **Event** |
| 2026 | Approved by Swissmedic for MET amplification and/or overexpression 2L NSCLC post TAGRISSO<sup>®</sup> therapy |
| 2025 | Approved by the NMPA for MET amplification 2L NSCLC post EGFR therapy; Full approval by the NMPA and NRDL inclusion for MET Exon 14 NSCLC (including 1L indication); Approved in Hong Kong under 1+ Mechanism |
| 2023 | NRDL inclusion (renewed in 2024) |
| 2021 | Conditional approval by the NMPA for advanced or metastatic 2L MET Exon 14 NSCLC and launched |
| 2011 | Worldwide license agreement with AstraZeneca |

---

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**Fruquintinib (ELUNATE** **<sup>®</sup> in China, FRUZAQLA<sup>®</sup> outside of China)**

**Mechanism of action:** fruquintinib is a selective oral inhibitor of VEGFR 1/2/3 kinases, designed to limit off-target kinase activity and improve drug exposure to achieve sustained target inhibition. Inhibition of the VEGFR can stop the growth of the vasculature around tumor and starve the tumor of nutrients and oxygen.

**Target Indications**: fruquintinib was approved and launched for 3L CRC in China in 2018 and approved in the US in 2023. According to Globocan, there were 517,000 new CRC cases in China (160,000 in the US, 540,000 in Europe and 146,000 in Japan) in 2022. About 15-20% of cases progress to 3L. The second approved indication of fruquintinib was in combination with TYVYT<sup>®</sup> for the treatment of 2L EMC with pMMR status. According to Globocan, there were 78,000 new EMC cases in China in 2022. About 15-20% of cases experience recurrence. Third potential indication of fruquintinib in combination with TYVYT<sup>®</sup> for 2L RCC is currently under NMPA review. According to Globocan, there were 74,000 new kidney cancer cases in China in 2022. About 90% are RCC and about 20-30% recur within the first five years.

**Clinical development:** FRUSICA-2 China Phase III data was presented at ESMO Congress 2025 for 2L RCC in combination with TYVYT<sup>®</sup>, showing **mPFS of 22.2 months (HR 0.37, p<0.0001)** and mDoR of 23.7 months. NMPA filing was accepted in June 2025.

---

| | | | | |
|:---|:---|:---|:---|:---|
| **Treatment** | **Name: Indication (control); NCT#** | **Endpoint** | **Phase** | **Status/Plan** |
| Fruquintinib + TYVYT<sup>®</sup> | **FRUSICA-2:** 2L **RCC**<br> (vs axitinib or everolimus);<br> NCT05522231 | PFS | China<br> II/III | **sNDA accepted by the NMPA** in Jun 2025.<br> **Data** at ESMO 2025. mPFS 22.2 months, <br> ORR 60.5%, mDoR 23.7 months, G≥3 TRAE 59.7% |
| Fruquintinib + TYVYT<sup>®</sup> | **RCC**<br> (single-arm); NCT03903705 | ORR | China<br> Ib/II | **Data** in *Targeted Oncology* Jan 2025. 1L/2L: ORR 68.2/60.0%, mPFS not reached/15.9 months, 36-month OS rate 72.4/58.3%, G≥3 TRAE 52.4% |
| Fruquintinib + TYVYT<sup>®</sup> | **FRUSICA-3:** 2L pMMR **EMC**<br> (vs paclitaxel or doxorubicin); <br> NCT06584032 | OS<br> PFS | China<br> III | **Initiated** in Dec 2024 |
| Fruquintinib + TYVYT<sup>®</sup> | **FRUSICA-1:** 2L+ pMMR **EMC**<br> (single-arm); NCT03903705 | ORR | China <br> II | NMPA **approved** in Dec 2024. Data at ASCO 2024. ORR 35.6%, mPFS 9.5 months, mOS 21.3 months, G≥3 TRAE 60.2% |
| Fruquintinib +<br> TYVYT<sup>®</sup> | **3L+** CRC<br> **(single-arm); NCT03903705** | ORR | China<br> Ib/II | **Data** in *European Journal of Cancer* 2023. 5mg 2w/1w regimen pMMR: ORR 20.0%, mPFS 6.9 months, mOS 20.0 months, G≥3 TRAE 47.7% |
| Fruquintinib<br> monotherapy | **FRESCO-2:** 3L+ **CRC**<br> (vs placebo); NCT04322539 | OS | Global<br> III | FDA **approved** in 2023. Data at *The Lancet* 2023. mPFS 3.7/1.8 months (HR 0.32, p<0.001), mOS 7.4/4.8 months (HR 0.66, p<0.001), G≥3 TRAE 62.7% |
| Fruquintinib<br> monotherapy | **FRESCO:** 3L **CRC**<br> (vs placebo); NCT02314819 | OS | China<br> III | NMPA **approved** in 2018. Data at *JAMA* 2018. mPFS 3.7/1.8 months (HR 0.26, p<0.0001), mOS 9.3/6.6 months (HR 0.65, p<0.0001), G≥3 TRAE 61.2% |

---

For 3L CRC, an IIT China Phase II study in combination with TAS-102 (trifluridine/tipiracil hydrochloride) updated data at ASCO 2025 with mPFS of 6.3 months and mOS of 18.4 months.

**Commercial achievement**: for China, fruquintinib in combination with TYVYT<sup>®</sup> in 2L EMC with pMMR is included in the NRDL effective January 1, 2026, enhancing patient access to this important therapeutic option. The average treatment duration in 2L EMC is almost twice that of 3L CRC. Outside China, our partner Takeda has obtained approval or launched fruquintinib in 38 countries to date.

---

| | |
|:---|:---|
| **Year** | **Event** |
| 2025 | NRDL inclusion (added 2L pMMR EMC); Fruzaqla<sup>®</sup> approved or launched in 38 countries to date |
| 2024 | Conditional approval by NMPA for 2L pMMR EMC |
| 2024 | Approved for 3L+ CRC in the EU, Switzerland, Argentina, Canada, Japan, the UK, Australia, Singapore, Israel, UAE, South Korea; reimbursement in Spain and Japan |
| 2024 | Approved for 3L+ CRC in Hong Kong (first medicine to be approved under the new 1+ Mechanism, first innovative oncology medicine to be directly added for full reimbursement in the Hospital Authority Drug Formulary) |
| 2023 | FDA approval for 3L+ CRC in the US, inclusion in NCCN Clinical Practice Guidelines |
| 2023 | Exclusive worldwide (excluding China) license agreement with Takeda |
| 2020 | NRDL inclusion (renewed in 2022 and 2024) |
| 2018 | Approved for 3L+ CRC by the NMPA and launched |
| 2013 | License and collaboration agreement with Eli Lilly in China (as amended) |

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**Surufatinib (SULANDA** **<sup>®</sup> in China)**

**Mechanism of action**: surufatinib is a novel, oral angio-immuno kinase inhibitor that selectively inhibits the tyrosine kinase activity associated with VEGFR and FGFR, both involved in tumor angiogenesis, and CSF-1R, which regulates tumor-associated macrophages, promoting immune response against tumor cells. Its dual mechanism of action may be suitable for combinations with other immunotherapies, such as PD-1 antibodies.

**Target indications**: surufatinib was approved in China for non-pancreatic NETs in 2020 and for pancreatic NETs in 2021. There are approximately 40,000 new patients per year in China. Surufatinib is also being investigated in a Phase II/III study for 1L PDAC. PDAC is an aggressive form of cancer, representing over 90% of pancreatic cancer cases. According to Globocan, there were 119,000 new pancreatic cancer cases in China in 2022.

**Clinical development**: Results from the Phase II part of a China Phase II/III study evaluating surufatinib combined with AiRuiKa<sup>®</sup>, nab-paclitaxel, and gemcitabine versus nab-paclitaxel plus gemcitabine for 1L PDAC were presented at ESMO Asia Congress 2025. The surufatinib combination demonstrated a **mPFS of 7.20 months (HR 0.499, p=0.0407)**. OS data were still immature but showed a favorable trend (not reached vs 8.48 months, unstratified HR 0.555). The Phase III part of this study dosed first patient in December 2025, targeting enrollment of 400 patients with OS as the primary endpoint.

---

| | | | | |
|:---|:---|:---|:---|:---|
| **Treatment** | **Name: Indication (control); NCT#** | **Endpoint** | **Phase** | **Status/Plan** |
| Surufatinib + AiRuiKa<sup>®</sup> + chemo | 1L **PDAC**<br> (vs chemo); NCT06361888 | OS | China<br> II/III | Phase III **initiated** in Dec 2025 |
| Surufatinib monotherapy | **SANET-ep: epNET** <br> (vs placebo); NCT02588170 | PFS | China<br> III | NMPA **approved** in 2021. ORR 19.2 vs 1.9%, <br> mPFS 10.9 vs 3.7 months (HR=0.49, p=0.001), <br> G≥3 TEAE 69.9 vs 27.1% |
| Surufatinib monotherapy | **SANET-p: pNET**<br> (vs placebo); NCT02589821 | PFS | China<br> III | NMPA **approved** in 2020. ORR 10.3 vs 0.0%, <br> mPFS 9.2 vs 3.8 months (HR=0.33, p<0.0001), <br> G≥3 TEAE 76.7 vs 33.8% |
| Surufatinib monotherapy | 2L+ **pNET/epNET**<br> (single-arm); NCT02549937 | PFS | US/EU<br> Ib | **Data** at ASCO 2021. pNET/epNET: ORR 18.8/6.3%, <br> mPFS 15.2/11.5 months, G≥3 AE 75% |
| Surufatinib monotherapy | **pNET/epNET**<br> (single-arm); NCT02267967 | ORR | China<br> Ib/II | **Data** in *Clinical Cancer Research* 2019. <br> pNET/epNET: ORR 19.0/15.0%, DCR 91.0/92.0%, <br> mPFS 21.2/13.4 months, G≥3 hypertension 33% |

---

**Updated clinical results of a Phase Ib/II IIT** for 1L metastatic PDAC, in combination with AiRuiKa<sup>®</sup>, chemotherapy nab-paclitaxel and S-1, were presented at ASCO 2025 showing ORR of 51.1% (vs 24.4% in chemotherapy control arm) and mPFS of 7.9 months (vs. 5.4 months) (NCT05218889).

**Commercial achievement**: surufatinib achieved second largest market share in NETs treatment during the third quarter of 2024, ahead of competitors SUTENT<sup>®</sup> and AFINITOR<sup>®</sup>.

---

| | |
|:---|:---|
| **Year** | **Event** |
| 2022 | NRDL inclusion (renewed in 2026) |
| 2021 | Approved for pancreatic NETs by the NMPA and launched |
| 2020 | Approved for non-pancreatic NETs by the NMPA and launched |

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**Sovleplenib (HMPL-523)**

**Mechanism of action**: sovleplenib is a novel, selective, oral inhibitor targeting Syk. Syk is a kinase upstream to PI3Kδ and BTK within the B-cell signaling pathway and a target for modulating B-cell signaling. We believe it could deliver the same outcome as inhibitors of BTK and PI3Kδ. Its signaling processes not only affect cells of immune responses, but also affect tissue pathology in autoimmune, inflammatory and allergic diseases.

**Target indications**: we are developing sovleplenib for ITP and wAIHA. ITP is an autoimmune disorder characterized by immunologic destruction of platelets and decreased platelet production, leading to increased risk of excessive bleeding and bruising. ITP is associated with fatigue (reported in up to 39% of adults with ITP) and impaired quality of life. As platelet destruction in ITP is mediated by Syk-dependent phagocytosis of FcγR-bound platelets, Syk inhibition is a promising approach to ITP management. According to IQVIA, China has 41,000 new ITP patients every year, on top of another **430,000 existing patients**. **About half of ITP patients fail** to have satisfactory results from currently approved treatments such as TPO/TPO-RAs. NMPA accepted our resubmitted **NDA filing for 2L ITP in February 2026, with additional data rolling in during the second half of 2026. The company is pursuing potential partnerships to continue overseas development.**

AIHA is another autoimmune disorder where the immune system mistakenly attacks and destroys its own red blood cells, leading to anemia. The incidence of AIHA is estimated to be 0.8-3.0/100,000 adults per year with an estimated prevalence of 17 per 100,000 adults and a death rate of 8-11%. wAIHA is the most common form of AIHA, accounting for about 75-80% of all adult AIHA cases. China has 26,000 new wAIHA patients per year.

**Clinical development**: The ESLIM-01 study showed that, in addition to its durable response in ITP patients, sovleplenib also improved significantly the quality of life in physical functioning and energy/fatigue (*p*<0.05). Most patients were heavily pretreated with a median of four prior lines of ITP therapy, and a majority (71.3%) of the patients had received prior TPO/TPO-RA treatment. Further post-hoc subgroup analysis of the study demonstrated consistent clinical benefits across ITP patients regardless of prior lines of ITP therapies or prior TPO/TPO-RA exposure.

Final analysis of the long-term efficacy and safety from the same study was presented at ASH 2025. A total of 179 patients (All Sov) were treated with at least one dose of sovleplenib, including 126 patients who initially received sovleplenib and 53 patients who crossed over from placebo (P-Sov). The durable response rate was 51.4% and 43.4% for the two groups, and long-term durable response rate was 61.5% and 64.2%. For the All Sov group, median ratio of cumulative duration to overall treatment duration was 71.8% for PLT ≥ 50×10<sup>9</sup>/L. Long-term sovleplenib treatment, with a median exposure of 86.3 weeks, did not increase safety risks and demonstrated low gastrointestinal toxicities.

We completed the ESLIM-02 China Phase III study for 2L wAIHA with positive topline results announced in January 2026. The study **met its primary endpoint** of durable hemoglobin response rate within weeks 5 to 24 of treatment. **We plan to submit the NDA to the NMPA in the first half of 2026.**

---

| | | | | |
|:---|:---|:---|:---|:---|
| **Treatment** | **Name: Indication (control); NCT#** | **Endpoint** | **Phase** | **Status/Plan** |
| Sovleplenib | **ESLIM-01**: ≥2L **ITP**<br> (vs placebo); NCT05029635 | DRR | China<br> III | **NDA resubmission accepted by the NMPA** in Feb 2026. <br> **Long-term data** at ASH 2025. <br> After placebo cross-over: ORR 81.0%, DRR 51.4%, G≥3 TEAE 33.0% |
| Sovleplenib | ≥2L **ITP**<br> (vs placebo); NCT03951623 | Safety | China<br> Ib/II | **Data** in *The Lancet Haematology* 2023. <br> Including placebo cross-over: ORR 80%, DRR 40%, <br> G≥3 TRAE 7% |
| Sovleplenib | **ESLIM-02:** 2L **warm AIHA** <br> (vs placebo); NCT05535933 | DRR | China <br> II/III | Phase III **full enrolled** in Jun 2025. Met primary endpoint. <br> NDA submission planned in first half of 2026 |
| Sovleplenib | 2L **warm AIHA** <br> (vs placebo); NCT05535933 | DRR | China <br> II/III | Phase II **data** in *The Lancet Haematology* 2025. <br> Including placebo cross-over: ORR 67%, DRR 48%,<br> G≥3 TEAE 33% |

---

There has been extensive research on oral small-molecule Syk inhibitors due to major unmet medical needs in inflammation and oncology. However, many Syk inhibitors have failed in the development stage due to their off-target toxicity as a result of lower kinase selectivity and possibly poor pharmacokinetic properties. Currently there is only one FDA-approved Syk inhibitor for ITP. There are competitors of different modalities targeting ITP, including a BTK inhibitor and a FcRn inhibitor. However, their 24-week durable response rates were either not disclosed or were significantly below that of sovleplenib.

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**Tazemetostat (TAZVERIK** **<sup>®</sup> in China)**

We have a collaboration with Epizyme, an Ipsen company, to research, develop, manufacture and commercialize tazemetostat in Greater China, including the mainland, Hong Kong, Macau and Taiwan.

**Mechanism of action**: tazemetostat is an inhibitor of EZH2. EZH2 catalyzes the methylation of histone H3 at lysine 27, which controls expression of genes and plays a role in cell physiology. Dysregulation of EZH2 occurs in a wide range of cancers with poor prognosis. Tazemetostat inhibits EZH2 which allows transcription of genes involved in cell cycle control and terminal differentiation, thus inhibiting cancer cell proliferation.

**Target indications**: tazemetostat was approved in China for 3L R/R EZH2-mutant follicular lymphoma in March 2025. China has about 9,000 new follicular lymphoma patients each year. About 1/3 of them will eventually require 3L treatment and the frequency of EZH2 mutation was about 25%. We are collaborating with Epizyme to expand the indication to 3L follicular lymphoma regardless of EZH2 status. Tazemetostat received FDA approval in 2020 for epithelioid sarcoma and R/R 2L+ EZH2-mutant follicular lymphoma or R/R follicular lymphoma with no satisfactory alternatives. It is marketed by Ipsen in the US and by Eisai in Japan. In May 2022, tazemetostat was approved in the Hainan International Medical Tourism Pilot Zone, under the Clinically Urgently Needed Imported Drugs scheme.

**Clinical development**: The NMPA conditional approval in March 2025 was supported by a China Phase II bridging study, showing ORR of 63.6% and mPFS of 15.4 months, in line with results of an earlier global trial (ORR 69%, mPFS 13.8 months). This bridging study also has another cohort for EZH2 wild-type patients, showing ORR of 35%, **and mPFS of 8.2 months.**

---

| | | | | |
|:---|:---|:---|:---|:---|
| **Treatment** | **Name: Indication (control); NCT#** | **Endpoint** | **Phase** | **Status/Plan** |
| Tazemetostat monotherapy | R/R 3L+ **follicular lymphoma**<br> (EZH2m/wildtype 2 cohorts); NCT05467943 | ORR | China <br> II | NMPA **approved** in Mar 2025. Data at EHA 2025.<br> EZH2m by IRC: ORR 63.6%, mPFS 15.4 months,<br> DoR 18m 51.6%, G≥3 TRAE 13.6% |
| Tazemetostat+ lenalidomide + rituximab (R²) | **SYMPHONY-1:** 2L+ **follicular lymphoma** (vs R² + placebo); NCT04224493 | PFS | Global<br> Ib/III | Ongoing since 2020. Phase Ib **Data** at ASH 2023. <br> ORR 90.9%, 18-month PFS 79.5%, 18-month DoR 81.0%, <br> G≥3 neutropenia 40.9%, RP3D determined |
| Tazemetostat+<br> amdizalisib | 2L+ R/R **PTCL**<br> (single-arm); NCT05713110 | ORR | China<br> II | **Data** at ICML 2025. ORR 60.7%, mPFS 8.3 months,<br> mDoR 6.5 months, G≥3 TRAE 48.3% |

---

**Commercial achievements**: The NMPA approval in March 2025 triggered an outgoing milestone payment to Epizyme. During the first week of July 2025, the first prescription for tazemetostat, our first commercialized hematological oncology drug, was filled with the drug delivered to the patient. In December 2025, tazemetostat was included in the Commercial Insurance Drug List. We have established a dedicated team to market tazemetostat and other hematological drugs under development, such as sovleplenib and ranosidenib, to be potentially commercialized by our team in coming years.

---

| | |
|:---|:---|
| **Year** | **Event** |
| 2025 | Inclusion in the Commercial Insurance Drug List<br> Conditional approval by the NMPA for R/R follicular lymphoma and launched |
| 2022 | Approved for R/R follicular lymphoma and launched in Hainan Pilot Zone |
| 2021 | License and collaboration agreement with Epizyme, now a subsidiary of Ipsen |
| 2020 | Approved by FDA for epithelioid sarcoma and R/R follicular lymphoma |

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**Fanregratinib (HMPL-453)**

**Mechanism of action**: fanregratinib is a novel, selective, oral inhibitor targeting FGFR 1/2/3. Activation of the FGFR pathway ultimately leads to increased cell proliferation, migration and survival. Aberrant FGFR signaling is associated with tumor growth, promotion of angiogenesis and resistance to anti-tumor therapies. Deregulation of the FGFR includes receptor amplification, activating mutations, gene fusions and receptor isoform switching.

**Target indications**: IHCC is one of the subtypes of primary bile duct cancer. In China, an estimated 61,900 newly diagnosed cases of IHCC occurred in 2015, having increased by 9.2% per year between 2006 and 2015. Approximately 10-15% of IHCC patients globally have tumors harboring FGFR2 fusions or rearrangements.

**Clinical development**: the registrational cohort of a China Phase II trial fully enrolled in February 2025, and subsequently met its primary endpoint of ORR. Results will be presented at an upcoming scientific conference **in the first half of 2026.** In December 2025, the NMPA accepted the NDA with priority review in 2L IHCC.

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| | | | | |
|:---|:---|:---|:---|:---|
| **Treatment** | **Name: Indication (control); NCT#** | **Endpoint** | **Phase** | **Status/Plan** |
| Fanregratinib monotherapy | 2L FGFR2 fusion/rearrangement <br> **IHCC** (single-arm); NCT04353375 | ORR | China<br> II reg. | **NDA accepted by the NMPA** in Dec 2025. <br> Fully enrolled in Feb 2025. <br> Results expected to be presented in 2026 |
| Fanregratinib monotherapy | 2L+ FGFR2 fusion/rearrangement<br> **IHCC** (2 dosages); NCT04353375 | ORR | China<br> II | **Data** at ASCO 2023. <br> At 300mg, ORR 50.0%, DCR 90%, G≥3 TRAE 23.1% |

---

**Ranosidenib (HMPL-306)**

**Mechanism of action**: ranosidenib is a novel dual-inhibitor of IDH1 and IDH2 enzymes. When mutated, IDH creates 2-hydroxyglutarate, which alters genetic programming and prevents cells from maturing, causing activation of oncogenes and deactivation of tumor-suppressor genes. Targeting both IDH1 and IDH2 mutations benefits patients harboring either IDH mutation and addresses acquired resistance due to isoform switching.

**Target indications**: IDH1 and IDH2 mutations have been implicated as drivers of certain malignancies, especially AML and gliomas. There were an estimated 19,700 new cases of AML in China in 2018 and it is estimated to reach 24,200 in China in 2030. About 15-25% of AML carry IDH1/2 mutations. Nearly 25% of AML patients fail to achieve remission after treatment.

**Clinical development**: The RAPHAEL China Phase III study initiated in May 2024 on 2L R/R IDH1/2-mutant AML patients, comparing ranosidenib monotherapy versus chemotherapy. With OS as primary endpoint, we are targeting to recruit 320 patients**.**

---

| | | | | |
|:---|:---|:---|:---|:---|
| **Treatment** | **Name: Indication (control); NCT#** | **Endpoint** | **Phase** | **Status/Plan** |
| Ranosidenib monotherapy | **RAPHAEL:** 2L R/R IDH1/2-mutant AML (vs chemo); NCT06387069 | OS | China<br> III | Ongoing since May 2024 |
| Ranosidenib monotherapy | IDH1/2-mutant **AML**<br> (single-arm); NCT04272957 | Safety | China<br> I | **Data** at EHA 2024. At RP2D, IDH1/2-mutant CR+CRh 45.5/50.0%; excluding RAS and FLT3 mutations, IDH1/2-mutant CR+CRh 50.0/62.0% |
| Ranosidenib monotherapy | R/R IDH1/2-mutant **AML**<br> (single-arm); NCT04764474 | Safety | US/EU<br> I | **Data** at EHA 2024. <br> At 250mg, ORR 60.0%, G≥3 TRAE 13.3% |
| Ranosidenib monotherapy | IDH1/2-mutant **glioma**<br> (single-arm); NCT07025018 | Safety | China<br> I | **Initiated** July 2025 |
| Ranosidenib monotherapy | IDH1/2-mutant **glioma**<br> (single-arm); NCT04762602 | Safety | US/Spain<br> I | **Data** at ASCO 2025. For lower-grade glioma patients, <br> ORR 20.0%, 18-month PFS rate 65.3%, G≥3 AE 28.6% |

---

One IDH1/2 dual inhibitor was approved in the US for IDH1/2-mutant Grade 2 astrocytoma or oligodendroglioma in August 2024. To date, there are no IDH1/2 dual inhibitors approved or in late-stage development for AML.

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**Early-stage Investigational Drug Candidates**

HUTCHMED retains all worldwide rights to the following early-stage drug candidates.

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| | | | |
|:---|:---|:---|:---|
| **Treatment** | **Name: Indication (control); NCT#** | **Endpoint** | **Status/Plan** |
| HMPL-760 + chemo | R/R **DLBCL**<br> (vs chemo); NCT06601504 | Safety<br> PFS China<br> II | Fully enrolled in 2024. <br> Phase III planned to initiate in H1 2026 |
| HMPL-760<br> monotherapy | **CLL, SLL, other NHL**<br> (single-arm); NCT05190068 | ORR China<br> I | **Data** at EHA 2024. ORR 73.1%, <br> median time to response 2.3 months |
| HMPL-506<br> monotherapy | MLL-rearranged/NPM1-mutant **acute leukemia** (single-arm); NCT06387082 | RP2D China<br> I | Ongoing since Jun 2024 |
| HMPL-415<br> monotherapy | **Solid tumors** <br> (single-arm); NCT05886374 | RP2D China<br> I | Fully enrolled |
| HMPL-653<br> monotherapy | **Solid tumors & tenosynovial giant cell tumors** (single-arm); NCT05277454 | RP2D China<br> I | Fully enrolled |
| HMPL-A83<br> monotherapy | Advanced **malignant neoplasms**<br> (single-arm); NCT05429008 | RP2D China<br> I | Fully enrolled |
| HMPL-295 <br> monotherapy | **Solid tumors**<br> (single-arm); NCT04908046 | G≥3 <br> TRAE China<br> I | Fully enrolled; **Data** at ASCO 2024. G≥3 TRAE 53.2% |

---

**HMPL-760 is a novel, non-covalent, third-generation BTK inhibitor.** It is a highly potent, selective, and reversible inhibitor with long target engagement against BTK, including wild-type and C481S-mutated BTK. The abnormal activation of B-cell receptor signaling is closely related to the development of B-cell type hematological cancers, which represent approximately 85% of all NHL cases. BTK is considered a validated target for drugs that aim to treat certain hematological cancers, however C481S mutation of BTK is a known resistance mechanism for first and second generation BTK inhibitors.

**HMPL-506 is a novel, selective Menin inhibitor.** Menin is a scaffold protein that controls gene expression and cell signaling. MLL rearrangement and NPM1 mutation play key roles in acute leukemia. Current research has demonstrated that the inhibition of Menin-MLL interaction is a feasible therapeutic strategy in these MLL or NPM1 types of acute leukemia. MLL-rearranged AML accounts for approximately 5% of adult AML, associated with poor prognosis, and NPM1-mutant AML accounts for approximately 30% of AML.

**HMPL-415 is a novel SHP2 allosteric inhibitor.** SHP2 modulates diverse cell signaling events that control metabolism, cell growth, differentiation, cell migration, transcription and oncogenic transformation. It regulates key signaling events including RAS/ERK, PI3K/AKT, JAK/STAT and PD-1 pathways downstream of several receptor tyrosine kinases. Dysregulation of SHP2 expression or activity causes many developmental diseases, and hematological and solid tumors.

**HMPL-653 is a novel, selective and potent CSF-1R inhibitor** designed to target CSF-1R driven tumors as a monotherapy or in combination with other drugs. Studies have shown that blocking the CSF-1R signaling pathway could effectively modulate the tumor microenvironment, relieve tumor immunosuppression, and synergize with other anti-cancer therapies such as immune checkpoint inhibitors to achieve tumor inhibition. CSF-1R inhibitors may treat tenosynovial giant cell tumors and a variety of malignancies in combinations.

**HMPL-A83 is a novel IgG4-type humanized anti-CD47 monoclonal antibody** that exhibits high affinity for CD47. CD47 is a cell surface transmembrane protein that is ubiquitously expressed on virtually all human cells. The overexpression of CD47 is reported in a variety of tumors and is believed to be associated with immune escape from macrophage-mediated phagocytosis. HMPL-A83 blocks CD47 binding to signal regulatory protein α and disrupts the "do not eat me" signal that cancer cells use to shield themselves from the immune system.

**HMPL-295 is a novel ERK inhibitor.** ERK is a downstream component of the RAS-RAF-MEK-ERK signaling cascade (MAPK pathway). The MAPK pathway is dysregulated in cancer, in which mutations or non-genetic events hyper-activate the pathway in up to 50% of cancers. ERK inhibition has the potential to overcome or avoid the intrinsic or acquired resistance from the inhibition of RAS, RAF and MEK. HMPL-295 inhibited ribosomal S6 kinase (RSK) phosphorylation which is a downstream signaling molecule regulated by ERK1/2 and stimulated by phorbol 12-myristate 13-acetate (PMA).

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**Collaborations with ImageneBio (Nasdaq:IMA) and Miragene Co**

Inmagene has been developing IMG-004 and IMG-007, two novel drug candidates discovered by HUTCHMED for the potential treatment of multiple immunological diseases, and funding their development. HUTCHMED had received shares as consideration for the exclusive license to develop, manufacture and commercialize these two drug candidates worldwide. In July 2025, Inmagene spun off **Miragene Co**, which holds the license rights to IMG-004; and merged with Ikena Oncology, Inc. to form **ImageneBio,** which holds the license rights to IMG-007. HUTCHMED now holds approximately 9.4% in Miragene Co and approximately 3.8% in ImageneBio.

---

| | | | | |
|:---|:---|:---|:---|:---|
| **Treatment** | **Name: Indication (control); NCT#** | **Endpoint** | **Phase** | **Status/Plan** |
| IMG-007 <br> monotherapy | **ADAPTIVE:** Adults with <br> moderate-to-severe **atopic dermatitis**; <br> NCT07037901 | % from<br> baseline<br> in EASI<br> score at <br> Week 20 | US/<br> Canada<br> IIb | **Initiated** in Jul 2025 |
| IMG-007 <br> monotherapy | **Alopecia areata** with 50% or greater<br> scalp hair loss (single-arm); <br> NCT06060977 | Safety | US/<br> Canada<br> IIa | Positive topline. Mean reduction in Severity of Alopecia Tool (SALT) of 21.7% (600mg) at Week 36 |
| IMG-007 <br> monotherapy | Adult healthy volunteers<br> (vs placebo); NCT05349097 | Safety | US<br> I | Multiple ascending dose completed |

---

**MANUFACTURING**

We have a drug product manufacturing facility in Suzhou which manufactures both clinical and commercial supplies for fruquintinib and surufatinib. Our new drug product facility in Shanghai has fully commenced operations and is expected to increase our novel drug product manufacturing capacity significantly and secure both clinical and commercial drug product supply. The Shanghai facility passed FDA inspection with zero observations in January 2026. Both clinical stage and commercial drug products have completed technology transfer, and almost all drug product manufacturing in the future will be done in the Shanghai factory. This can bring significant production cost savings.

Commercial supply of savolitinib was first delivered from the Shanghai facility in late 2024. We received the NMPA manufacturing approval of surufatinib at the Shanghai facility and started commercial production, and we also received the NMPA manufacturing approval for fruquintinib in December 2025. Currently we can deliver commercial batches of fruquintinib from three manufacturing sites to the global and China markets: our own facilities in Suzhou and Shanghai and a third site in Switzerland.

Production for our first ATTC candidates has been completed by the Shanghai facility. We have also completed production of the first batch of investigational drug products to supply the first global clinical trials.

**OTHER VENTURES**

In the first half of 2025, HUTCHMED completed the disposal of a 45% equity interest in SHPL to focus on our global innovative drug discovery and development businesses. After the disposal, our Other Ventures is predominantly our Distribution Business (a 51%-held joint venture with Sinopharm Group Co. Ltd.) which provides services to third-party pharmaceutical companies in China.

In 2025, our Other Ventures consolidated revenue was steady at $263.0 million (2024: $266.8m). Consolidated net income attributable to HUTCHMED from our Other Ventures decreased to $25.5 million (2024: $47.7m) primarily due to disposal of our 45% equity interest in SHPL in April 2025.

**Johnny Cheng<br> Acting Chief Executive Officer and Chief Financial Officer<br> March 5, 2026**

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**USE OF NON-GAAP FINANCIAL MEASURES AND RECONCILIATION**

In addition to financial information prepared in accordance with US GAAP, this announcement also contains certain non-GAAP financial measures based on management's view of performance including:

· Adjusted
 Group net cash flows excluding financing activities

· CER

Management uses such measures internally for planning and forecasting purposes and to measure the HUTCHMED Group's overall performance. We believe these adjusted financial measures provide useful and meaningful information to us and investors because they enhance investors' understanding of the continuing operating performance of our business and facilitate the comparison of performance between past and future periods. These adjusted financial measures are non-GAAP measures and should be considered in addition to, but not as a substitute for, the information prepared in accordance with US GAAP. Other companies may define these measures in different ways.

*Adjusted Group net cash flows excluding financing activities:* We exclude deposits in and proceeds from short-term investments for the period and exclude the net cash generated from financing activities for the period to derive our adjusted Group net cash flows excluding financing activities. We believe the presentation of adjusted Group net cash flows excluding financing activities provides useful and meaningful information about the change in our cash resources excluding those from financing activities which may present significant period-to-period differences.

*CER:* We remove the effects of currency movements from period-to-period comparisons by retranslating the current period's performance at previous period's foreign currency exchange rates. Because we have significant operations in China, the RMB to US dollar exchange rates used for translation may have a significant effect on our reported results. We believe the presentation at CER provides useful and meaningful information because it facilitates period-to-period comparisons of our results and increases the transparency of our underlying performance.

**Reconciliation of GAAP change in net cash (used in)/generated from operating activities to adjusted Group net cash flows excluding financing activities:**

---

| | | |
|:---|:---|:---|
| | **Year Ended December 31,** | **Year Ended December 31,** |
| <br>($ in millions) | **2025** | **2024** |
| Net cash (used in)/generated from operating activities | (64.7) | 0.5 |
| Net cash used in investing activities | (29.4) | (96.0) |
| Effect of exchange rate changes on cash and cash equivalents | 3.6 | (3.4) |
| &nbsp;&nbsp;&nbsp;Excludes: Deposits in short-term investments | 2742.2 | 1848.8 |
| &nbsp;&nbsp;&nbsp;Excludes: Proceeds from short-term investments | (2128.4) | (1769.4) |
| Adjusted Group net cash flows excluding financing activities | 523.3 | (19.5) |

---

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**Reconciliation of GAAP revenue and net income attributable to HUTCHMED to CER:**

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| ($ in millions, except %) | **Year Ended <br> December 31,** | **Year Ended <br> December 31,** | **Change Amount** | **Change Amount** | **Change Amount** | **Change %** | **Change %** | **Change %** |
|  | **2025** | **2024** | **Actual** | **CER** | **Exchange<br> effect** | **Actual** | **CER** | **Exchange<br> effect** |
| **Consolidated revenue** | **548.5** | **630.2** | **(81.7)** | **(83.5)** | **1.8** | **-13%** | **-13%** | **—** |
| — **Oncology/Immunology\*** | **285.5** | **363.4** | **(77.9)** | **(78.7)** | **0.8** | **-21%** | **-21%** | **—** |
| \* Includes: |  |  |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;— Oncology Products | 214.4 | 271.5 | (57.1) | (57.9) | 0.8 | -21% | -21% |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;—FRUZAQLA<sup>®</sup> | 89.4 | 110.8 | (21.4) | (21.4) |  | -19% | -19% |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;—ELUNATE<sup>®</sup> | 76.9 | 86.3 | (9.4) | (9.9) | 0.5 | -11% | -11% |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;—SULANDA<sup>®</sup> | 27.0 | 49.0 | (22.0) | (22.1) | 0.1 | -45% | -45% |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;—ORPATHYS<sup>®</sup> | 18.6 | 24.5 | (5.9) | (6.1) | 0.2 | -24% | -24% |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;—TAZVERIK<sup>®</sup> | 2.5 | 0.9 | 1.6 | 1.6 |  | 158% | 156% | 2% |
| &nbsp;&nbsp;&nbsp;— Takeda upfront, regulatory milestones and R&D services | 51.6 | 67.0 | (15.4) | (15.4) |  | -23% | -23% |  |
| &nbsp;&nbsp;&nbsp;— Other revenue (R&D services and licensing) | 19.5 | 24.9 | (5.4) | (5.4) |  | -21% | -21% |  |
| — **Other Ventures** | **263.0** | **266.8** | **(3.8)** | **(4.8)** | **1.0** | **-1%** | **-1%** |  |
| **Consolidated net income attributable to HUTCHMED — Other Ventures** | **25.5** | **47.7** | **(22.2)** | **(22.0)** | **(0.2)** | **-47%** | **-46%** | **-1%** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— Consolidated entities | 0.9 | 1.2 | (0.3) | (0.3) |  | -22% | -22% |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— An equity investee <br> — SHPL | 24.6 | 46.5 | (21.9) | (21.7) | (0.2) | -47% | -46% | -1% |

---

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**GROUP CAPITAL RESOURCES**

**LIQUIDITY AND CAPITAL RESOURCES**

To date, we have taken a multi-source approach to fund our operations, including through cash flows generated, dividend payments and divestment proceeds from our Oncology/Immunology and Other Ventures operations, service and milestone and upfront payments from our collaboration partners, bank borrowings, investments from third parties, proceeds from our listings on various stock exchanges and follow-on offerings.

Significantly boosted by the partial disposal of equity stake in SHPL, we generated a net income attributable to HUTCHMED of $456.9 million for the year ended December 31, 2025 (2024: $37.7m).

As of December 31, 2025, we had cash and cash equivalents and short-term investments of $1,367.3 million, unutilized bank facilities of $41.2 million and $93.2 million in bank borrowings.

Certain of our subsidiaries including those registered as wholly foreign-owned enterprises, and an equity investee in China, are required to set aside at least 10% of their after-tax profits to their non-distributable reserve funds until such reserves reach 50% of their registered capital. Profit appropriated to the reserve funds for our subsidiaries and equity investee incorporated in PRC was approximately $2,380,000 and $32,000 for the years ended December 31, 2025 and 2024, respectively.

In addition, as a result of PRC regulations restricting dividend distributions from such reserve funds and from a company's registered capital, our PRC subsidiaries are restricted in their ability to transfer a certain amount of their net assets to us as cash dividends, loans or advances. This restricted portion amounted to $2.0 million as of December 31, 2025.

**CASH FLOW**

---

| | | |
|:---|:---|:---|
| (in $'000) | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** |
| **Cash Flow Data:** |  |  |
| Net cash (used in)/generated from operating activities | (64657) | 497 |
| Net cash used in investing activities | (29410) | (96060) |
| Net cash generated from/(used in) financing activities | 7836 | (30667) |
| Net decrease in cash and cash equivalents | (86231) | (126230) |
| Effect of exchange rate changes | 3603 | (3401) |
| Cash and cash equivalents at beginning of the year | 153958 | 283589 |
| Cash and cash equivalents at end of the year | 71330 | 153958 |

---

**Net Cash (used in)/generated from Operating Activities**

Net cash used in operating activities was $64.7 million for the year ended December 31, 2025, compared to $0.5 million net cash generated for the year ended December 31, 2024. The net increase in spending of $65.2 million was mainly due to a capital gain tax payment of $59.5 million for the partial divestment of SHPL in April 2025.

**Net Cash used in Investing Activities**

Net cash used in investing activities was $29.4 million for the year ended December 31, 2025, compared to $96.1 million for the year ended December 31, 2024. The net amounts used for the year ended December 31, 2025 were due to $613.8 million deposited into short-term investments along with $10.0 million regulatory approval milestone payment and $14.1 million for capital expenditures, offset by gross proceeds from the partial divestment of SHPL of $608.5 million. The net amounts used for the year ended December 31, 2024 were mainly due to capital expenditures of $17.9 million and net deposits in short-term investments of $79.4 million.

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**Net Cash generated from/(used in) Financing Activities**

Net cash generated from financing activities was $7.8 million for the year ended December 31, 2025, compared to $30.7 million net cash used for the year ended December 31, 2024. The net amounts generated for the year ended December 31, 2025 were mainly due to $6.3 million net amount drawn from bank borrowings to primarily settle the capital expenditures for the Shanghai manufacturing site. The net amounts used for the year ended December 31, 2024 were mainly due to $36.1 million purchases of shares of the Company by a trustee (which are referred to as "treasury shares" in the Company's consolidated financial statements and accounted as treasury shares under applicable accounting standards but do not constitute treasury shares under the Rules Governing the Listing of Securities on HKEX (the "Hong Kong Listing Rules")) for the settlement of equity awards of the Company, offset by $5.6 million net amount drawn from bank borrowings.

**LOAN FACILITIES**

In October 2021, our subsidiary entered into a 10-year fixed asset loan facility agreement with BOC for the provision of a secured credit facility in the amount of $107.4 million (RMB754.9 million) with an annual interest rate at the 5-year China LPR less 0.8% (which was supplemented in June 2022). This credit facility is guaranteed by the immediate holding company of the subsidiary, and secured by the underlying leasehold land and buildings (Shanghai manufacturing facility), and includes certain financial covenant requirements. For the year ended December 31, 2025, $1.5 million (RMB10.4 million) was repaid and cannot be further drawn from the facility. The outstanding bank borrowings was $73.0 million (RMB512.5 million) as of December 31, 2025.

In October 2025, BOC extended a short-term unsecured working capital loan facility to our subsidiary in the amount of $28.5 million (RMB200.0 million) with an annual interest rate at the 1-year China LPR less 0.89%. This credit facility includes certain financial covenant requirements. As of December 31, 2025, $20.2 million (RMB142.1 million) was utilized from the loan facility.

**CONTRACTUAL OBLIGATIONS AND COMMITMENTS**

The following table sets forth our contractual obligations as of December 31, 2025. Our purchase obligations relate to property, plant and equipment that are contracted for but not yet paid. Our lease obligations primarily comprise future aggregate minimum lease payments in respect of various factories, warehouse, offices and other assets under non-cancellable lease agreements.

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| (in $'000) | **Payment Due by Period** | **Payment Due by Period** | **Payment Due by Period** | **Payment Due by Period** | **Payment Due by Period** |
|  | **Total** | **Less than <br> 1 Year** | **1-3 Years** | **3-5 Years** | **More than 5 Years** |
| Bank borrowings | 93160 | 24971 | 14153 | 29977 | 24059 |
| Interest on bank borrowings | 8947 | 2386 | 3558 | 2359 | 644 |
| Purchase obligations | 692 | 675 | 17 |  |  |
| Lease obligations | 6860 | 4964 | 1734 | 162 |  |
|  | 109659 | 32996 | 19462 | 32498 | 24703 |

---

**FOREIGN EXCHANGE RISK**

A substantial portion of our revenue and expenses are denominated in renminbi, and our consolidated financial statements are presented in US dollars. While we do not believe that we currently have any significant direct foreign exchange risk and have not used any derivative financial instruments to hedge our exposure to such risk, any significant fluctuation in the value of renminbi may adversely affect our cash flows, results of operations and financial condition in the future.

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The value of the renminbi against the US dollar and other currencies may fluctuate and is affected by, among other things, changes in political, economic and market factors, including but not limited to monetary policies, interest rates, geopolitical relations, tariffs and economic performance. The conversion of renminbi into foreign currencies, including US dollars, has been based on rates set by the PBOC. If we decide to convert renminbi into US dollars for the purpose of making payments for dividends on our ordinary shares or ADSs or for other business purposes, appreciation of the US dollar against the renminbi would have a negative effect on the US dollar amounts available to us. On the other hand, if we need to convert US dollars into renminbi for business purposes, e.g. capital expenditures and working capital, appreciation of the renminbi against the US dollar would have a negative effect on the renminbi amounts we would receive from the conversion. In addition, for certain cash and bank balances deposited with banks in the PRC, if we decide to convert them into foreign currencies, they are subject to the rules and regulations of foreign exchange control promulgated by the PRC government.

**CREDIT RISK**

Substantially all of our bank deposits are in major financial institutions, which we believe are of high credit quality. We limit the amount of credit exposure to any single financial institution. We make periodic assessments of the recoverability of trade and other receivables and amounts due from related parties. Our historical experience in collection of receivables falls within the recorded allowances, and we believe that we have made adequate provision for uncollectible receivables.

**INTEREST RATE RISK**

We have no significant interest-bearing assets except for bank deposits. Our exposure to changes in interest rates is mainly attributable to our bank borrowings, which bear interest at floating interest rates and expose us to cash flow interest rate risk. We have not used any interest rate swaps to hedge our exposure to interest rate risk. We have performed sensitivity analysis for the effects on our results for the period from changes in interest rates on floating rate borrowings. The sensitivity to interest rates used is based on the market forecasts available at the end of the reporting period and under the economic environments in which we operate, with other variables held constant. According to the analysis, the impact on our results of a 1.0% interest rate shift would be a maximum increase/decrease of $0.9 million for the year ended December 31, 2025.

**OFF-BALANCE SHEET ARRANGEMENTS**

We did not have during the years presented, and we do not currently have, any material off-balance sheet arrangements.

**CONTINGENT LIABILITIES**

Other than as disclosed in note 17 to the consolidated financial statements, the Group does not have any other significant commitments or contingent liabilities as at December 31, 2025.

**GEARING RATIO**

The gearing ratio of the Group, which was calculated by dividing total interest-bearing loans by total equity, was 7.4% as of December 31, 2025, a decrease from 10.7% as of December 31, 2024. The decrease was primarily due to the increase in equity from the gain on divestment of SHPL during the year.

**SIGNIFICANT INVESTMENTS HELD**

We did not hold any significant investments in the equity of any companies as of December 31, 2025.

**FUTURE PLANS FOR MATERIAL INVESTMENTS AND CAPITAL ASSETS**

Note 17 to the consolidated financial statements discloses our capital commitment as of December 31, 2025.

**MATERIAL ACQUISITIONS AND DISPOSALS OF SUBSIDIARIES, ASSOCIATES AND JOINT VENTURES**

During the year ended December 31, 2025, except for our divestment of an equity investee as disclosed in note 22 to the consolidated financial statements, we did not have any other material acquisitions and disposals of subsidiaries, associates and joint ventures.

**PLEDGE OF ASSETS**

Our 10-year fixed asset loan facility agreement with BOC is secured by the underlying leasehold land and buildings. The outstanding bank borrowing was $73.0 million (RMB 512.5 million) as at December 31, 2025.

**INFLATION**

In recent years, China has not experienced significant inflation, and thus inflation has not had a material impact on our results of operations. According to the National Bureau of Statistics of China, the Consumer Price Index in China decreased by 0.3% in 2023, increased by 0.1% in 2024 and increased by 0.8% in 2025. Although we have not been materially affected by inflation in the past, we can provide no assurance that we will not be affected in the future by higher rates of inflation in China.

**FINAL DIVIDEND**

The Board does not recommend any final dividend for the year ended December 31, 2025.

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**OTHER INFORMATION**

**CORPORATE STRATEGY**

The primary objective of the Company is to be a leader in the discovery, development and commercialization of targeted therapies and immunotherapies for the treatment of cancer and immunological diseases. The strategy of the Company is to leverage the highly specialized expertise of the drug discovery division, the Oncology/Immunology operations, to develop and expand the drug candidate portfolio of the Group for the global market, building on the first-mover advantage in the development and launch of novel cancer medicines in China, and engaging partners for late-stage development and commercialization outside China. This strategy is aligned with the Company's culture of innovation and high engagement and empowerment of employees with a strong focus on reward and recognition. The Chairman's Statement and the Operations Review contain discussions and analyses of the Group's opportunities, performance and the basis on which the Group generates or preserves value over the longer term and the basis on which the Group will execute its strategy for delivering its objectives. The Group also focuses on sustainability and delivering business solutions to support the transition to a low-carbon economy. Further information on the sustainability initiatives of the Group and its key relationships with stakeholders can also be found in the standalone Sustainability Report of the Group.

**SUSTAINABILITY**

The key sustainability mission of the Group is to create long-term value for stakeholders by aligning its sustainability objectives to the strategic development of its businesses. The Board of Directors ("the Board") has the overall responsibility to ensure that sustainability issues are integrated into the operations, strategy and long-term development of the Group. It provides oversight of the sustainability performance of the Group through closely monitoring key sustainability matters and performance indicators, along with trends, risks, and opportunities that may impact the business development of the Group. Supported by the Sustainability Committee, leadership team (including executives and senior management) and sustainability working groups, the Board oversees the management approach to sustainability matters and the formulation of sustainability strategies.

A standalone Sustainability Report of the Company for 2025 will be published alongside the 2025 Annual Report in April 2026 and will include further information on the Group's sustainability initiatives and their performance. It will further discuss the abovementioned sustainability mission and strategies, management approach, progress of goals and targets, material quantitative data, as well as policies and key initiatives of the Group. Over the course of 2026, the Group continues to engage its stakeholders to identify areas for improvement in these sustainability fronts.

**HUMAN RESOURCES**

As at December 31, 2025, the Group employed approximately 1,800 (December 31, 2024: ~1,810) full time staff members. Staff costs for the year ended December 31, 2025, including directors' emoluments, totaled $177.1 million (2024: $190.9 million).

The Group fully recognizes the importance of high-quality employees in sustaining market leadership. Salary and benefits are kept at competitive levels, while individual performance is rewarded within the general framework of the salary, bonus and incentive system of the Group, which is reviewed annually. Employees are provided with a wide range of benefits that include medical coverage, provident funds and retirement plans, and long-service awards. The Group stresses the importance of staff development and provides training programs on an ongoing basis. Employees are also encouraged to play an active role in community care activities.

**CLOSURE OF REGISTER OF MEMBERS**

The register of members of the Company will be closed from Thursday, May 7, 2026 to Tuesday, May 12, 2026, both days inclusive, during which period no transfer of shares will be effected. The record date to determine shareholders' entitlement to attend and vote at the 2026 Annual General Meeting (or at any adjournment or postponement thereof) is Thursday, May 7, 2026. All share certificates with completed transfer forms, either overleaf or separately, must be lodged with (a) (for shares registered on the Hong Kong branch register of members) the Hong Kong Branch Share Registrar of the Company, Computershare Hong Kong Investor Services Limited, at Shops 1712-1716, 17th Floor, Hopewell Centre, 183 Queen's Road East, Wanchai, Hong Kong, no later than 4:30pm Hong Kong time on Wednesday, May 6, 2026 or (b) (for shares registered on the principal register of members) the Principal Share Registrar of the Company, Computershare Investor Services (Jersey) Limited c/o Computershare Investor Services PLC, The Pavilions, Bridgwater Road, Bristol, BS99 6ZY, United Kingdom, no later than 4:30 pm London time on Wednesday, May 6, 2026.

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**PURCHASE, SALE OR REDEMPTION OF LISTED SECURITIES**

During the year ended December 31, 2025, neither the Company nor any of its subsidiaries has purchased, sold or redeemed any of the listed securities (including sale of treasury shares (within the meaning of the Hong Kong Listing Rules)) of the Company.

**COMPLIANCE WITH THE CORPORATE GOVERNANCE CODE**

The Company strives to attain and maintain high standards of corporate governance best suited to the needs and interests of the Company and its subsidiaries as it believes that effective corporate governance framework is fundamental to promoting and safeguarding interests of shareholders and other stakeholders and enhancing shareholder value. Accordingly, the Company has adopted and applied corporate governance principles and practices that emphasize a quality Board, effective risk management and internal control systems, stringent disclosure practices, transparency and accountability as well as effective communication and engagement with shareholders and other stakeholders. It is, in addition, committed to continuously enhancing these standards and practices and inculcating a robust culture of compliance and ethical governance underlying the business operations and practices across the Group.

The Company has complied throughout the year ended December 31, 2025 with all applicable code provisions of the Hong Kong Corporate Governance Code contained in Part 2 of Appendix C1 of the Hong Kong Listing Rules, as in force during the reporting period.

**COMPLIANCE WITH THE SHARE DEALINGS CODE FOR SECURITIES TRANSACTIONS BY DIRECTORS**

The Board has adopted the Code on Dealings in Shares which is on terms no less exacting than the required standard set out in the Model Code for Securities Transactions by Directors of Listed Issuers set out in Appendix C3 of the Hong Kong Listing Rules as the code of conduct regulating Directors' dealings in securities of the Company. In response to specific enquiries made, all Directors have confirmed that they have complied with the required standards set out in such code regarding their securities transactions throughout their tenure during the year ended December 31, 2025.

**ANNUAL GENERAL MEETING**

The Annual General Meeting of the Company will be held on Tuesday, May 12, 2026. Notice of the 2026 Annual General Meeting will be published and issued to shareholders in due course.

**AUDIT REPORT ON THE ANNUAL FINANCIAL STATEMENTS**

The consolidated financial statements of the Company and its subsidiary companies for the year ended December 31, 2025 prepared in accordance with accounting principles generally accepted in the US have been audited by the Company's auditors, PricewaterhouseCoopers. The consolidated financial statements of the Company and its subsidiary companies for the year ended December 31, 2025 have also been reviewed by the Audit Committee of the Company.

**IMPORTANT EVENTS AFTER THE REPORTING DATE**

Save as disclosed above, no important events affecting the Company occurred since December 31, 2025 and up to the date of this announcement.

**PUBLICATION OF FULL YEAR RESULTS AND ANNUAL REPORT**

This full year results announcement is published on the websites of HKEX (<u>www.hkexnews.hk</u>), the London Stock Exchange (<u>www.londonstockexchange.com</u>), the US Securities and Exchange Commission (<u>www.sec.gov</u>) and the Company (<u>www.hutch-med.com</u>). The annual report of the Group for the year ended December 31, 2025 will be published on the websites of HKEX and the Company in April 2026.

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**GLOSSARY**

---

| | |
|:---|:---|
| *1L* | *First-line.* |
| *2L* | *Second-line.* |
| *3L* | *Third-line.* |
| *AACR* | *American Association for Cancer Research conference.* |
| *ADC* | *Antibody-drug conjugate.* |
| *ADS* | *American depositary shares, each of which represents five ordinary shares.* |
| *AIHA* | *Autoimmune hemolytic anemia.* |
| *AKT* | *Protein kinase B.* |
| *AML* | *Acute myeloid leukemia.* |
| *ASCO* | *American Society of Clinical Oncology conference.* |
| *ASH* | *American Society of Hematology conference.* |
| *AstraZeneca* | *AstraZeneca AB, a subsidiary of AstraZeneca plc.* |
| *ATTC* | *Antibody-targeted therapy conjugates.* |
| *BICR* | *Blinded independent central review.* |
| *BOC* | *Bank of China Limited.* |
| *BTK* | *Bruton's tyrosine kinase.* |
| *CDP Worldwide* | *Non-profit organization formerly known as the Carbon Disclosure Project.* |
| *CER* | *Constant exchange rate. We also report changes in performance at CER which is a non-GAAP measure. Please refer to "Use of Non-GAAP Financial Measures and Reconciliation" for further information relevant to the interpretation of these financial measures and reconciliations of these financial measures to the most comparable GAAP measures.* |
| *CLL* | *Chronic lymphocytic leukemia.* |
| *CNS* | *Central nervous system.* |
| *CR+CRh* | *Combined complete remission + complete remission with partial hematologic recovery.* |
| *CRC* | *Colorectal cancer.* |
| *CSF-1R* | *Colony-stimulating factor 1 receptor.* |
| *DCR* | *Disease control rate.* |
| *DLBCL* | *Diffuse large B-cell lymphoma.* |
| *DoR* | *Duration of response.* |
| *DRR* | *Durable response rate* |
| *EASI* | *Eczema area and severity index.* |
| *EGFR* | *Epidermal growth factor receptor.* |
| *EGFRm* | *Epidermal growth factor receptor mutated.* |
| *EHA* | *European Hematology Association.* |
| *ELCC* | *The European Lung Cancer Congress.* |
| *Eli Lilly* | *Lilly (Shanghai) Management Company Limited.* |
| *EMC* | *Endometrial cancer.* |
| *Epizyme* | *Epizyme, Inc., an Ipsen company.* |
| *epNET* | *Extra-pancreatic neuroendocrine tumor.* |
| *ERK* | *Extracellular signal-regulated kinase.* |
| *ESG* | *Environmental, Social and Governance.* |
| *ESMO* | *European Society for Medical Oncology conference.* |
| *EZH2* | *Enhancer of zeste homolog 2.* |
| *EZH2m* | *Enhancer of zeste homolog 2 mutated.* |
| *FDA* | *Food and Drug Administration.* |
| *FGFR* | *Fibroblast growth factor receptor.* |
| *FLT3* | *FMS-like tyrosine kinase 3.* |
| *FPI* | *First patient in.* |
| *GAAP* | *Generally Accepted Accounting Principles.* |
| *GC* | *Gastric cancer.* |
| *Hainan Pilot Zone* | *Hainan Boao Lecheng International Medical Tourism Pilot Zone.* |
| *HKEX* | *The Main Board of The Stock Exchange of Hong Kong Limited.* |
| *HR* | *Hazard Ratio.* |
| *ICML* | *International Conference on Malignant Lymphoma.* |
| *IDH1/2* | *Isocitrate dehydrogenase-1 OR isocitrate dehydrogenase-2.* |
| *IHCC* | *Intrahepatic cholangiocarcinoma.* |
| *IIT* | *Investigator-initiated trial.* |
| *ImageneBio* | *ImageneBio, Inc.* |
| *IND* | *Investigational new drug application.* |
| *Inmagene* | *Inmagene Biopharmaceuticals, which merged with Ikena Oncology, Inc. to form ImageneBio in July 2025.* |
| *In-market sales* | *Total sales to third parties provided by Eli Lilly (ELUNATE<sup>®</sup>), Takeda (FRUZAQLA<sup>®</sup>), AstraZeneca (ORPATHYS<sup>®</sup>) and HUTCHMED (ELUNATE<sup>®</sup>, SULANDA<sup>®</sup>, ORPATHYS<sup>®</sup> and TAZVERIK<sup>®</sup>).* |
| *Ipsen* | *Ipsen SA, parent of Epizyme, Inc.* |
| *IRC* | *Independent review committee.* |
| *ISDS* | *Inflammatory Skin Disease Summit.* |

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---

| | |
|:---|:---|
| *ITP* | *Immune thrombocytopenia purpura.* |
| *ITT* | *Intention-to-treat* |
| *JAK* | *Janus kinase.* |
| *JAMA* | *Journal of the American Medical Association.* |
| *LPI* | *Last patient in.* |
| *LPR* | *Loan Prime Rate.* |
| *MAA* | *Marketing Authorisation Application.* |
| *MAPK* | *Mitogen-activated protein kinase.* |
| *mDoR* | *median Duration of response.* |
| *MET* | *The ligand mesenchymal epithelial transition factor, or the gene named MET that encodes this ligand.* |
| *METex14* | *MET exon 14 skipping alteration.* |
| *MLL* | *Mixed-lineage leukemia.* |
| *mOS* | *median Overall survival.* |
| *mPFS* | *median Progression-free survival.* |
| *MSS* | *Microsatellite stable.* |
| *NDA* | *New Drug Application.* |
| *NET* | *Neuroendocrine tumor.* |
| *NHL* | *Non-Hodgkin lymphoma.* |
| *NHS* | *National Health Service in the United Kingdom.* |
| *NHSA* | *China National Healthcare Security Administration.* |
| *NICE* | *National Institute for Health and Care Excellence of the United Kingdom.* |
| *NMPA* | *China National Medical Products Administration.* |
| *NPM1* | *Nucleophosmin 1.* |
| *NRDL* | *China National Reimbursement Drug List.* |
| *NSCLC* | *Non-small cell lung cancer.* |
| *ORR* | *Objective response rate.* |
| *OS* | *Overall survival.* |
| *PBOC* | *People's Bank of China.* |
| *PD-1* | *Programmed cell death protein-1.* |
| *PDAC* | *Pancreatic ductal adenocarcinoma.* |
| *PFS* | *Progression free survival.* |
| *PI3K* | *Phosphatidylinositol 3-kinase.* |
| *PI3Kδ* | *Phosphoinositide 3-kinase-δ.* |
| *pMMR* | *Proficient mismatch repair.* |
| *pNET* | *Pancreatic neuroendocrine tumor.* |
| *PRCC* | *Papillary renal cell carcinoma.* |
| *PTCL* | *Peripheral T-cell lymphomas.* |
| *R/R* | *Relapsed and/or refractory.* |
| *RAS* | *Rat sarcoma.* |
| *RCC* | *Renal cell carcinoma.* |
| *RMB or "renminbi"* | *The legal currency of the PRC.* |
| *RP2D* | *The recommended phase 2 dose.* |
| *RP3D* | *The recommended phase 3 dose.* |
| *S&A* | *Selling and administrative expenses.* |
| *SHP2* | *SH2 containing protein tyrosine phosphatase-2.* |
| *SHPL* | *Shanghai Hutchison Pharmaceuticals Limited.* |
| *SLL* | *Small lymphocytic lymphoma.* |
| *sNDA* | *Supplemental New Drug Application.* |
| *STAT* | *Signal transducer and activator of transcription.* |
| *Syk* | *Spleen tyrosine kinase.* |
| *Takeda* | *Takeda Pharmaceuticals International AG, a subsidiary of Takeda Pharmaceutical Company Limited.* |
| *TEAE* | *Treatment emergent adverse events.* |
| *TKI* | *Tyrosine kinase inhibitor.* |
| *TPO* | *Thrombopoietin.* |
| *TPO-RA* | *Thrombopoietin receptor agonists.* |
| *TRAE* | *Treatment-related adverse events.* |
| *VEGFR* | *Vascular endothelial growth factor receptor.* |
| *wAIHA* | *Warm autoimmune hemolytic anemia.* |
| *WCLC* | *World Conference on Lung Cancer.* |

---

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**CONSOLIDATED FINANCIAL STATEMENTS**

**HUTCHMED (CHINA) LIMITED<br> CONSOLIDATED BALANCE SHEETS<br> (IN US$'000, EXCEPT SHARE DATA)**

---

| | | | |
|:---|:---|:---|:---|
|  | | **December 31,** | **December 31,** |
|  | <br>**Note** | **2025** | **2024** |
| **Assets** |  |  |  |
| Current assets |  |  |  |
| &nbsp;&nbsp;&nbsp;Cash and cash equivalents | 5 | 71330 | 153958 |
| &nbsp;&nbsp;&nbsp;&nbsp;Short-term investments | 5 | 1295945 | 682152 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accounts receivable | 6 | 126750 | 155537 |
| &nbsp;&nbsp;&nbsp;&nbsp;Other receivables, prepayments and deposits | 7 | 21773 | 16609 |
| &nbsp;&nbsp;&nbsp;&nbsp;Amounts due from related parties | 25(ii) | 10415 | 7899 |
| &nbsp;&nbsp;&nbsp;&nbsp;Inventories | 8 | 41129 | 50400 |
| **Total current assets** |  | **1567342** | **1066555** |
| Property, plant and equipment | 9 | 94623 | 92498 |
| Right-of-use assets | 10 | 3027 | 4497 |
| Deferred tax assets | 26(ii) | 12655 | 12448 |
| Investment in equity investees | 11 | 10865 | 77765 |
| Investment in equity security | 12 |  | 5000 |
| Amounts due from related parties | 25(ii) | 41381 |  |
| Goodwill |  | 3112 | 2990 |
| Other non-current assets |  | 20092 | 12443 |
| **Total assets** |  | **1753097** | **1274196** |
| **Liabilities and shareholders' equity** |  |  |  |
| Current liabilities |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Accounts payable | 13 | 45533 | 42521 |
| &nbsp;&nbsp;&nbsp;&nbsp;Other payables and accruals | 14 | 208892 | 256124 |
| &nbsp;&nbsp;&nbsp;&nbsp;Short-term bank borrowings | 15 | 24971 | 23372 |
| &nbsp;&nbsp;&nbsp;&nbsp;Deferred revenue | 20 | 31415 | 50071 |
| &nbsp;&nbsp;&nbsp;&nbsp;Income tax payable | 26(iii) | 2083 | 1549 |
| &nbsp;&nbsp;&nbsp;&nbsp;Lease liabilities | 10 | 2881 | 2925 |
| **Total current liabilities** |  | **315775** | **376562** |
| Lease liabilities, non-current portion | 10 | 1852 | 4089 |
| Deferred tax liabilities | 26(ii) | 255 | 2990 |
| Long-term bank borrowings | 15 | 68189 | 59434 |
| Deferred revenue, non-current portion | 20 | 20132 | 48432 |
| Amounts due to related parties | 25(ii) | 6325 | 6617 |
| Other non-current liabilities | 16 | 89307 | 4219 |
| **Total liabilities** |  | **501835** | **502343** |
| Commitments and contingencies | 17 |  |  |
| **Company's shareholders' equity** |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Ordinary shares; $0.10 par value; 1,500,000,000 shares authorized; 872,327,620 and 871,601,095 shares issued at December 31, 2025 and 2024 respectively | 18 | 87233 | 87160 |
| &nbsp;&nbsp;&nbsp;&nbsp;Additional paid-in capital |  | 1533868 | 1517526 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accumulated losses |  | (378643) | (833172) |
| &nbsp;&nbsp;&nbsp;&nbsp;Accumulated other comprehensive loss |  | (4532) | (11585) |
| **Total Company's shareholders' equity** |  | **1237926** | **759929** |
| Non-controlling interests |  | 13336 | 11924 |
| **Total shareholders' equity** |  | **1251262** | **771853** |
| **Total liabilities and shareholders' equity** |  | **1753097** | **1274196** |

---

The accompanying notes are an integral part of these consolidated financial statements.

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**HUTCHMED (CHINA) LIMITED<br> Consolidated Statements of Operations<br> (in US$'000, except share and per share data)**

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | <br>**Note** | **2025** | **2024** | **2023** |
| **Revenue** |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Goods — third parties |  | 393477 | 401382 | 388924 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— related parties | 25(i) | 1322 | 3854 | 8264 |
| &nbsp;&nbsp;&nbsp;Services — commercialization — third parties |  | 45300 | 52485 | 48608 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— research and development — related parties | 25(i) |  | 471 | 481 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— collaboration research and development — third parties |  | 27904 | 57968 | 80397 |
| &nbsp;&nbsp;&nbsp;Other collaboration revenue |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— royalties — third parties |  | 68419 | 71041 | 32470 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— licensing — third parties |  | 12090 | 43000 | 278855 |
| **Total revenue** | 20 | **548512** | **630201** | **837999** |
| **Operating expenses** |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Cost of goods — third parties |  | (291360) | (294918) | (331984) |
| &nbsp;&nbsp;&nbsp;Cost of goods — related parties |  | (775) | (1861) | (4777) |
| &nbsp;&nbsp;&nbsp;Cost of services — commercialization — third parties |  | (44214) | (52105) | (47686) |
| &nbsp;&nbsp;&nbsp;Research and development expenses | 21 | (148295) | (212109) | (302001) |
| &nbsp;&nbsp;&nbsp;Selling expenses |  | (36306) | (48617) | (53392) |
| &nbsp;&nbsp;&nbsp;Administrative expenses |  | (66722) | (64296) | (79784) |
| **Total operating expenses** |  | **(587672)** | **(673906)** | **(819624)** |
|  |  | **(39160)** | **(43705)** | **18375** |
| Gain on divestment of an equity investee | 22 | 476896 |  |  |
| **Other income/(expense)** |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Interest income | 28 | 49877 | 40080 | 36145 |
| &nbsp;&nbsp;&nbsp;Other income | 24 | 19710 | 10274 | 12949 |
| &nbsp;&nbsp;&nbsp;Interest expense | 28 | (2865) | (2872) | (759) |
| &nbsp;&nbsp;&nbsp;Other expense | 24 | (5767) | (4884) | (8402) |
| **Total other income/(expense)** |  | **60955** | **42598** | **39933** |
| **Income/(loss) before income taxes and equity in earnings of equity investees** |  | **498691** | **(1107)** | **58308** |
| Income tax expense | 26(i) | (63610) | (7192) | (4509) |
| Equity in earnings of equity investees, net of tax | 11 | 22651 | 46469 | 47295 |
| **Net income** |  | **457732** | **38170** | **101094** |
| Less: Net income attributable to non-controlling interests |  | (823) | (441) | (314) |
| **Net income attributable to the Company** |  | **456909** | **37729** | **100780** |
| Earnings per share attributable to the Company (US$ per share) |  |  |  |  |
| &nbsp;&nbsp;&nbsp;— basic | 27 | 0.53 | 0.04 | 0.12 |
| &nbsp;&nbsp;&nbsp;— diluted | 27 | 0.52 | 0.04 | 0.12 |
| Number of shares used in per share calculation |  |  |  |  |
| &nbsp;&nbsp;&nbsp;— basic | 27 | 858276608 | 855351683 | 849654296 |
| &nbsp;&nbsp;&nbsp;— diluted | 27 | 872891120 | 872829129 | 869196348 |

---

The accompanying notes are an integral part of these consolidated financial statements.

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**HUTCHMED (CHINA) LIMITED<br> Consolidated Statements of Comprehensive INCOME<br> (in US$'000)**

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
| **Net income** | **457732** | **38170** | **101094** |
| Other comprehensive income/(loss) |  |  |  |
| &nbsp;&nbsp;&nbsp;Foreign currency translation income/(loss) | 2503 | (3753) | (6592) |
| **Total comprehensive income** | **460235** | **34417** | **94502** |
| Less: Comprehensive (income)/loss attributable to non-controlling interests | (1384) | (110) | 39 |
| **Total comprehensive income attributable to the Company** | **458851** | **34307** | **94541** |

---

The accompanying notes are an integral part of these consolidated financial statements.

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**HUTCHMED (CHINA) LIMITED<br> Consolidated Statements of Changes in Shareholders' Equity<br> (in US$'000, except share data in '000)**

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
|  | **Ordinary<br> Shares<br> Number** | **Ordinary<br> Shares<br> Value** | **Additional<br> Paid-in<br> Capital** | **Accumulated<br> Losses** | **Accumulated<br> Other<br> Comprehensive<br> Loss** | **Total<br> Company's<br> Shareholders'<br> Equity** | **Non-<br> controlling<br> Interests** | **Total<br> Shareholders'<br> Equity** |
| **As at January 1, 2023** | **864775** | **86478** | **1497273** | **(971481)** | **(1903)** | **610367** | **26503** | **636870** |
| Net income |  |  |  | 100780 |  | 100780 | 314 | 101094 |
| Issuances in relation to share option exercises | 6481 | 648 | 4446 |  |  | 5094 |  | 5094 |
| Share-based compensation |  |  |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Share options |  |  | 6175 |  |  | 6175 | 9 | 6184 |
| &nbsp;&nbsp;&nbsp;Long-term incentive plan ("LTIP") |  |  | 23619 |  |  | 23619 | (4) | 23615 |
|  |  |  | 29794 |  |  | 29794 | 5 | 29799 |
| LTIP — treasury shares acquired and held by Trustee |  |  | (9071) |  |  | (9071) |  | (9071) |
| Dividends declared to non-controlling shareholders of subsidiaries (Note 25(iii)) |  |  |  |  |  |  | (9068) | (9068) |
| Transfer between reserves |  |  | 168 | (168) |  |  |  |  |
| Divestment of subsidiaries |  |  | (114) |  | (25) | (139) | (4555) | (4694) |
| Divestment of other equity investee |  |  | (49) |  | 4 | (45) |  | (45) |
| Foreign currency translation adjustments |  |  |  |  | (6239) | (6239) | (353) | (6592) |
| **As at December 31, 2023** | **871256** | **87126** | **1522447** | **(870869)** | **(8163)** | **730541** | **12846** | **743387** |
| Net income |  |  |  | 37729 |  | 37729 | 441 | 38170 |
| Issuances in relation to share option exercises | 345 | 34 | 756 |  |  | 790 |  | 790 |
| Share-based compensation |  |  |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Share options |  |  | 3061 |  |  | 3061 | 8 | 3069 |
| &nbsp;&nbsp;&nbsp;LTIP |  |  | 27294 |  |  | 27294 | (40) | 27254 |
|  |  |  | 30355 |  |  | 30355 | (32) | 30323 |
| LTIP — treasury shares acquired and held by Trustee (Note 19(ii)) |  |  | (36064) |  |  | (36064) |  | (36064) |
| Dividend declared to a non-controlling shareholder of a subsidiary (Note 25(iii)) |  |  |  |  |  |  | (1000) | (1000) |
| Transfer between reserves |  |  | 32 | (32) |  |  |  |  |
| Foreign currency translation adjustments |  |  |  |  | (3422) | (3422) | (331) | (3753) |
| **As at December 31, 2024** | **871601** | **87160** | **1517526** | **(833172)** | **(11585)** | **759929** | **11924** | **771853** |
| Net income |  |  |  | 456909 |  | 456909 | 823 | 457732 |
| Issuances in relation to share option exercises | 727 | 73 | 1505 |  |  | 1578 |  | 1578 |
| Share-based compensation |  |  |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Share options |  |  | 2508 |  |  | 2508 | 5 | 2513 |
| &nbsp;&nbsp;&nbsp;LTIP |  |  | 11737 |  |  | 11737 | 23 | 11760 |
|  |  |  | 14245 |  |  | 14245 | 28 | 14273 |
| Divestment of an equity investee (Note 22) |  |  | (2374) |  | 5107 | 2733 |  | 2733 |
| Acquisition of an equity investee (Note 11) |  |  | 586 |  | 4 | 590 |  | 590 |
| Transfer between reserves |  |  | 2380 | (2380) |  |  |  |  |
| Foreign currency translation adjustments |  |  |  |  | 1942 | 1942 | 561 | 2503 |
| **As at December 31, 2025** | **872328** | **87233** | **1533868** | **(378643)** | **(4532)** | **1237926** | **13336** | **1251262** |

---

The accompanying notes are an integral part of these consolidated financial statements.

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**HUTCHMED (CHINA) LIMITED<br> Consolidated Statements of Cash Flows<br> (in US$'000)**

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | <br>**Note** | **2025** | **2024** | **2023** |
| Net cash (used in)/generated from operating activities | 29 | (64657) | 497 | 219258 |
| **Investing activities** |  |  |  |  |
| Purchases of property, plant and equipment |  | (14148) | (17933) | (32612) |
| Proceeds from disposal of property, plant and equipment |  | 28 |  |  |
| Refund of leasehold land deposit |  |  | 1278 |  |
| Deposits in short-term investments |  | (2742210) | (1848808) | (1627875) |
| Proceeds from short-term investments |  | 2128417 | 1769403 | 1342846 |
| Proceeds received from divestment of Shanghai Hutchison Pharmaceuticals Limited ("SHPL") | 22 | 608503 |  |  |
| Acquisition of an intangible asset | 28(i) | (10000) |  |  |
| Dividend and proceeds received from divestment of Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Company Limited |  |  |  | 29495 |
| Proceeds from divestment of subsidiaries | 25(i) |  |  | 5103 |
| Cash disposed from divestment of subsidiaries |  |  |  | (8093) |
| Net cash used in investing activities |  | (29410) | (96060) | (291136) |
| **Financing activities** |  |  |  |  |
| Proceeds from issuances of ordinary shares | 19(i) | 1578 | 790 | 5094 |
| Purchases of treasury shares | 19(ii) |  | (36064) | (9071) |
| Dividends paid to non-controlling shareholders of subsidiaries | 25(iii) |  | (1000) | (9068) |
| Proceeds from bank borrowings |  | 30898 | 36199 | 61705 |
| Repayment of bank borrowings |  | (24640) | (30592) |  |
| Net cash generated from/(used in) financing activities |  | 7836 | (30667) | 48660 |
| Net decrease in cash and cash equivalents |  | (86231) | (126230) | (23218) |
| Effect of exchange rate changes on cash and cash equivalents |  | 3603 | (3401) | (6471) |
|  |  | (82628) | (129631) | (29689) |
| **Cash and cash equivalents** |  |  |  |  |
| Cash and cash equivalents at beginning of year |  | 153958 | 283589 | 313278 |
| Cash and cash equivalents at end of year |  | 71330 | 153958 | 283589 |
| **Supplemental disclosure for cash flow information** |  |  |  |  |
| Cash paid for interest |  | 2518 | 2509 | 421 |
| Cash paid for tax, net of refunds | 26(iii) | 62411 | 3587 | 3728 |
| **Supplemental disclosure for non-cash activities** |  |  |  |  |
| (Decrease)/increase in accrued capital expenditures |  | (4222) | (7540) | 5713 |
| Vesting of treasury shares for LTIP | 19(ii) | 15442 | 42127 | 18148 |

---

The accompanying notes are an integral part of these consolidated financial statements.

35 / 69

**HUTCHMED (CHINA) LIMITED<br> NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS**

**1. Organization and Nature of Business**

HUTCHMED (China) Limited (the "Company") and its subsidiaries (together the "Group") are principally engaged in researching, developing, manufacturing and marketing pharmaceutical products. The Group has research and development facilities and manufacturing plants in the People's Republic of China (the "PRC") and sell its products mainly in the PRC, including Hong Kong and Macau. In addition, the Group has established international operations in the United States of America (the "US") and Europe.

The Company's ordinary shares are listed on the Main Board of The Stock Exchange of Hong Kong Limited and the AIM market of the London Stock Exchange, and its American depositary shares ("ADS") are traded on the Nasdaq Global Select Market.

***Liquidity***

As at December 31, 2025, the Group had accumulated losses of US$378,643,000 primarily due to its spending in drug research and development activities. The Group regularly monitors current and expected liquidity requirements to ensure that it maintains sufficient cash balances and adequate credit facilities to meet its liquidity requirements in the short and long term. As at December 31, 2025, the Group had cash and cash equivalents of US$71,330,000, short-term investments of US$1,295,945,000 and unutilized bank borrowing facilities of US$41,248,000. Short-term investments comprised of bank deposits maturing over three months.

Based on the Group's operating plan, the existing cash and cash equivalents, short-term investments and unutilized bank borrowing facilities are considered to be sufficient to meet the cash requirements to fund planned operations and other commitments for at least the next twelve months from the issuance date of the consolidated financial statements.

**2. Particulars of Principal Subsidiaries**

---

| | | | | |
|:---|:---|:---|:---|:---|
| | | **Equity interest attributable<br> to the Group** | **Equity interest attributable<br> to the Group** | |
| | | **December 31,** | **December 31,** | |
| <br>**Name** | **Place of** <br>**establishment**<br>**andoperations** | **2025** | **2024** | <br>**Principal activities** |
| **Subsidiaries** |  |  |  |  |
| HUTCHMED Limited | PRC | 99.75% | 99.75% | Research, development, manufacture and commercialization of pharmaceutical products |
| HUTCHMED International Corporation | US | 99.75% | 99.75% | Provision of professional, scientific and technical support services |
| Shanghai Hutchison Whampoa Pharmaceutical Sales Limited | PRC | 50.87% | 50.87% | Provision of sales, distribution and marketing services to pharmaceutical manufacturers |
| Hutchison Healthcare Limited | PRC | 100% | 100% | Manufacture and distribution of healthcare products |

---

36 / 69

**3. Summary of Significant Accounting Policies**

***Principles of Consolidation and Basis of Presentation***

The accompanying consolidated financial statements reflect the accounts of the Company and all of its subsidiaries in which a controlling interest is maintained. When a subsidiary is deconsolidated from the date that control ceases, any gain or loss on the divestment of the interest sold is recognized in profit or loss. Amounts previously recognized in other comprehensive income/(loss) for the subsidiary are transferred to the consolidated statements of operations as part of the gain or loss on the divestment. All inter-company balances and transactions have been eliminated in consolidation. The consolidated financial statements have been prepared in conformity with generally accepted accounting principles in the US ("US GAAP").

***Use of Estimates***

The preparation of consolidated financial statements in conformity with US GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the consolidated financial statements and the reported amounts of revenue and expenses during the reporting period. Actual results could differ from management's estimates and assumptions.

***Foreign Currency Translation***

The Company's presentation currency and functional currency is the US dollar ("US$"). The financial statements of its subsidiaries with a functional currency other than the US$ have been translated into the Company's presentation currency. All assets and liabilities of the subsidiaries are translated using year-end exchange rates and revenue and expenses are translated at average exchange rates for the year. Translation adjustments are reflected in accumulated other comprehensive income/(loss) in shareholders' equity.

***Foreign Currency Risk***

The Group's operating transactions and its assets and liabilities in the PRC are mainly denominated in Renminbi ("RMB"), which is not freely convertible into foreign currencies. The Group's cash and cash equivalents denominated in RMB are subject to government controls. The value of the RMB is subject to fluctuations from central government policy changes and international economic and political developments that affect the supply and demand of RMB in the foreign exchange market. In the PRC, certain foreign exchange transactions are required by law to be transacted only by authorized financial institutions at exchange rates set by the People's Bank of China (the "PBOC"). Remittances in currencies other than RMB by the Group in the PRC must be processed through the PBOC or other PRC foreign exchange regulatory bodies which require certain supporting documentation in order to complete the remittance.

***Allowance for Current Expected Credit Losses and Concentration of Credit Risk***

Financial instruments that potentially expose the Group to credit risk consist primarily of cash and cash equivalents, short-term investments, and financial assets not carried at fair value including accounts receivable, other receivables and amounts due from related parties.

The Group recognizes an allowance for current expected credit losses ("CECLs") on financial assets not carried at fair value. The allowance for CECLs reflects the Group's significant estimates and judgments in determining the portfolio groups and loss rates. CECLs are calculated over the expected life of the financial assets on an individual or a portfolio basis considering information available about the counterparties' credit situation and collectability of the specific cash flows, including information about past events, current conditions and future forecasts.

The Group places substantially all of its cash and cash equivalents and short-term investments in major financial institutions, which management believes are of high credit quality. The Group has a practice to limit the amount of credit exposure to any particular financial institution. Additionally, the Group has policies in place to ensure that sales are made to customers with an appropriate credit history and the Group performs periodic credit evaluations of its customers. Normally the Group does not require collateral from trade debtors. The Group has not had any material credit losses.

37 / 69

***Provision for profit guarantee***

The Group recognizes a provision when (1) we have a present obligation as a result of a past event, (2) it is probable that an outflow of resources embodying economic benefits will be required to settle the obligation, and (3) a reliable estimate can be made of the amount of the obligation. The provision for profit guarantee was estimated based on a discounted cash flow analysis using assumptions including forecasted revenue and discount rate. At each reporting date, the Group remeasures the provision at fair value based on projected forecasts of the equity investee's performance against the guaranteed yearly net income after tax targets. Changes in estimates are recognized in the consolidated statements of operations' gain on divestment of an equity investee in the period in which the estimate is revised.

***Cash and Cash Equivalents***

The Group considers all highly liquid investments purchased with original maturities of three months or less to be cash equivalents. Cash and cash equivalents consist primarily of cash on hand and bank deposits and are stated at cost, which approximates fair value.

***Short-term Investments***

Short-term investments include deposits placed with banks with original maturities of more than three months but less than one year.

***Accounts Receivable***

Accounts receivable are stated at the amount management expects to collect from customers based on their outstanding invoices. The allowance for CECLs reflects the Group's current estimate of credit losses expected to be incurred over the life of the receivables. The Group considers various factors in establishing, monitoring, and adjusting its allowance for CECLs including the aging of the accounts and aging trends, the historical level of charge-offs, and specific exposures related to particular customers. The Group also monitors other risk factors and forward-looking information, such as country risk, when determining credit limits for customers and establishing adequate allowances for CECLs. Accounts receivable are written off after all reasonable means to collect the full amount (including litigation, where appropriate) have been exhausted.

***Inventories***

Inventories are stated at the lower of cost or net realizable value. Cost is determined using the weighted average cost method. The cost of finished goods comprises raw materials, direct labor, other direct costs and related production overheads based on normal operating capacity. Net realizable value is the estimated selling price in the ordinary course of business, less reasonably predictable costs of completion, disposal and transportation. A provision for excess and obsolete inventory will be made based primarily on forecasts of product demand and production requirements. The excess balance determined by this analysis becomes the basis for revised carrying cost and the written-down value of the inventory becomes its cost. Written-down inventory is not written up if market conditions improve.

***Property, Plant and Equipment***

Property, plant and equipment consist of buildings, leasehold improvements, plant and equipment, furniture and fixtures, other equipment and motor vehicles. Property, plant and equipment are stated at cost, net of accumulated depreciation. Depreciation is computed using the straight-line method over the estimated useful lives of the depreciable assets.

---

| | |
|:---|:---|
| Buildings | 20 years |
| Plant and equipment | 5-10 years |
| Furniture and fixtures, other equipment and motor vehicles | 4-5 years |
| Leasehold improvements | Shorter of (a) 5 years or (b) remaining term of lease |

---

Additions and improvements that extend the useful life of an asset are capitalized. Repairs and maintenance costs are expensed as incurred.

***Impairment of Long-lived Assets***

The Group evaluates the recoverability of long-lived assets in accordance with authoritative guidance on accounting for the impairment or disposal of long-lived assets. The Group evaluates long-lived assets for impairment whenever events or changes in circumstances indicate that the carrying value of these assets may not be recoverable. If indicators of impairment exist, the first step of the impairment test is performed to assess if the carrying value of the asset group exceeds the undiscounted cash flows of the asset group. If yes, the second step of the impairment test is performed in order to determine if the carrying value of the asset group exceeds the fair value. If yes, impairment is recognized for the excess.

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***Investment in Equity Investees***

Investment in equity investees over which the Group has significant influence is accounted for using the equity method. The Group evaluates the equity method investment for impairment when events or circumstances suggest that its carrying amount may not be recoverable. An impairment charge would be recognized in earnings for a decline in value that is determined to be other-than-temporary after assessing the severity and duration of the impairment and the likelihood of recovery before disposal. The investment is recorded at fair value only if impairment is recognized. When the Group's share of losses of the equity investee equals or exceeds its interest in the equity investee, the Group does not recognize further losses, unless the Group has incurred obligations or made payments or guarantees on behalf of the equity investee.

***Investment in Equity Security without Readily Determinable Fair Value***

For the investment in equity security without readily determinable fair value, the Group elected the measurement alternative to record the investment at cost, which was its initial fair value estimated using the discounted cash flow method. Under the measurement alternative, there will be no subsequent mark-to-market adjustments to the investment's carrying value, other than (i) any observable price changes in orderly transactions for the identical or similar investment of the same issuer or (ii) impairment. At each reporting date, the Group makes a qualitative assessment of whether the investment is impaired and if the assessment indicates impairment, the Group estimates the investment's fair value and if the fair value is less than the investment's carrying value, the Group recognizes an impairment loss equal to the difference between the carrying value and fair value.

***Leasehold Land***

Leasehold land represents amounts paid to acquire the right to use the land on which various plants and buildings are situated for a specified period of time from the date the respective right was granted and are stated at cost less accumulated amortization and impairment loss, if any. Amortization is computed using the straight-line basis over the lease period of 50 years.

***Goodwill***

Goodwill represents the excess of the purchase price plus fair value of non-controlling interests over the fair value of identifiable assets and liabilities acquired. Goodwill is not amortized, but is tested for impairment at the reporting unit level on at least an annual basis or when an event occurs or circumstances change that would more likely than not reduce the fair value of a reporting unit below its carrying amount. When performing an evaluation of goodwill impairment, the Group has the option to first assess qualitative factors, such as significant events and changes to expectations and activities that may have occurred since the last impairment evaluation, to determine if it is more likely than not that goodwill might be impaired. If as a result of the qualitative assessment, that it is more likely than not that the fair value of the reporting unit is less than its carrying amount, the quantitative fair value test is performed to determine if the fair value of the reporting unit exceeds its carrying value.

***Other Intangible Asset***

Other intangible asset with finite useful life is carried at cost less accumulated amortization and impairment loss, if any. Amortization is computed using the straight-line basis over the estimated useful life of the asset.

***Borrowings***

Borrowings are recognized initially at fair value, net of debt issuance costs incurred. Borrowings are subsequently stated at amortized cost; any difference between the proceeds (net of debt issuance costs) and the redemption value is recognized in the consolidated statements of operations over the period of the borrowings using the effective interest method.

***Ordinary Shares***

The Company's ordinary shares are stated at par value of US$0.10 per ordinary share. The difference between the consideration received, net of issuance cost, and the par value is recorded in additional paid-in capital.

The Company's ordinary shares are traded in the form of ordinary shares and ADS. Each ADS represents five ordinary shares.

***Treasury Shares***

The Group accounts for treasury shares under the cost method. The treasury shares are purchased for the purpose of the LTIP and held by a trustee appointed by the Group (the "Trustee") prior to vesting.

***Share-based Compensation***

***Share Options***

The Group recognizes share-based compensation expense on share options granted to employees and directors based on their estimated grant date fair value using the Polynomial model and Monte Carlo simulation model. The Polynomial pricing model and Monte Carlo simulation model use various inputs to measure fair value, including the market value of the Company's underlying ordinary shares at the grant date, contractual terms, estimated volatility, risk-free interest rates and expected dividend yields. The Group recognizes share-based compensation expense in the consolidated statements of operations on a graded vesting basis over the requisite service period, and accounts for forfeitures as they occur.

Share options are classified as equity-settled awards. Share-based compensation expense, when recognized, is charged to the consolidated statements of operations with the corresponding entry to additional paid-in capital.

39 / 69

***LTIP***

The Group recognizes the share-based compensation expense on the LTIP awards based on a fixed or determinable monetary amount on a straight-line basis for each annual tranche awarded over the requisite period. For LTIP awards with performance targets, prior to their determination date, the amount of LTIP awards that is expected to vest takes into consideration the achievement of the performance conditions and the extent to which the performance conditions are likely to be met. Performance conditions vary by awards, and may include targets for shareholder returns, revenue and profitability.

These LTIP awards are classified as liability-settled awards before the determination date (i.e. the date when the achievement of any performance conditions are known), as they settle in a variable number of shares based on a determinable monetary amount, which is determined upon the actual achievement of performance targets. As the extent of achievement of the performance targets is uncertain prior to the determination date, a probability based on management's assessment of the achievement of the performance targets has been assigned to calculate the amount to be recognized as an expense over the requisite period.

After the determination date or if the LTIP awards have no performance conditions, the LTIP awards are classified as equity-settled awards. If the performance target is achieved, the Group will pay the determined monetary amount to the Trustee to purchase ordinary shares of the Company or the equivalent ADS. Any cumulative compensation expense previously recognized as a liability will be transferred to additional paid-in capital. If the performance target is not achieved, no ordinary shares or ADS of the Company will be purchased and the amount previously recorded in the liability will be reversed and included in the consolidated statements of operations.

***Defined Contribution Plans***

The Group's subsidiaries in the PRC participate in a government-mandated multi-employer defined contribution plans pursuant to which certain retirement, medical and other welfare benefits are provided to employees. The relevant labor regulations require the Group's subsidiaries in the PRC to pay the local labor and social welfare authority's monthly contributions at a stated contribution rate based on the monthly basic compensation of qualified employees. The relevant local labor and social welfare authorities are responsible for meeting all retirement benefits obligations and the Group's subsidiaries in the PRC have no further commitments beyond their monthly contributions. The contributions to the plan are expensed as incurred.

The Group also makes payments to other defined contribution plans for the benefit of employees employed by subsidiaries outside the PRC. The defined contribution plans are generally funded by the relevant companies and by payments from employees.

The Group's contributions to defined contribution plans including all medical and other welfare benefits for the years ended December 31, 2025, 2024 and 2023 were US$23,691,000, US$23,082,000 and US$22,136,000 respectively.

***Revenue Recognition***

Revenue is measured based on consideration specified in a contract with a customer, and excludes any sales incentives and amounts collected on behalf of third parties. Taxes assessed by a governmental authority that are both imposed on and concurrent with a specific revenue-producing transaction, that are collected by the Group from a customer, are also excluded from revenue. The Group recognizes revenue when it satisfies a performance obligation by transferring control over a good, service or license to a customer.

**(i)** **Goods and services** 

The Group principally generates revenue from (1) sales of goods, which are the manufacture or purchase and distribution of pharmaceutical products and other healthcare products, and (2) provision of services, which are the provision of sales, distribution and marketing services to pharmaceutical manufacturers. The Group evaluates whether it is the principal or agent for these contracts. Where the Group obtains control of the goods for distribution, it is the principal (i.e. recognizes sales of goods on a gross basis). Where the Group does not obtain control of the goods for distribution, it is the agent (i.e. recognizes provision of services on a net basis). Control is primarily evidenced by taking physical possession and inventory risk of the goods.

Revenue from sales of goods is recognized when the customer takes possession of the goods. This usually occurs upon completed delivery of the goods to the customer site. The amount of revenue recognized is adjusted for expected sales incentives as stipulated in the contract, which are generally issued to customers as direct discounts at the point-of-sale or indirectly in the form of rebates. Sales incentives are estimated using the expected value method. Additionally, sales are generally made with a limited right of return under certain conditions. Revenue is recorded net of provisions for sales discounts and returns.

Revenue from provision of services is recognized when the benefits of the services transfer to the customer over time, which is based on the proportionate value of services rendered as determined under the terms of the relevant contract. Additionally, when the amounts that can be invoiced correspond directly with the value to the customer for performance completed to date, the Group recognizes revenue from provision of services based on amounts that can be invoiced to the customer.

Deferred revenue is recognized if consideration is received in advance of transferring control of the goods or rendering of services. Accounts receivable is recognized if the Group has an unconditional right to bill the customer, which is generally when the customer takes possession of the goods or services are rendered. Payment terms differ by subsidiary and customer, but generally range from 45 to 180 days from the invoice date.

**(ii)** **License and collaboration contracts** 

The Group's Oncology/Immunology reportable segment includes revenue generated from license and collaboration contracts, which generally contain multiple performance obligations including (1) the licenses to the development, commercialization and manufacture rights of a drug compound, (2) the research and development services for each specified treatment indication, and (3) other deliverables, which are accounted for separately if they are distinct, i.e. if a product or service is separately identifiable from other items in the arrangement and if a customer can benefit from it on its own or with other resources that are readily available to the customer.

The transaction price generally includes fixed and variable consideration in the form of upfront payment, research and development cost reimbursements, contingent milestone payments and sales-based royalties. Contingent milestone payments are not included in the transaction price until it becomes probable that a significant reversal of revenue will not occur, which is generally when the specified milestone is achieved. The allocation of the transaction price to each performance obligation is based on the relative standalone selling prices of each performance obligation determined at the inception of the contract. The Group estimates the standalone selling prices based on the income approach and cost plus margin approach. Control of the license to the drug compounds transfers at the inception date of the collaboration agreements and consequently, amounts allocated to this performance obligation are generally recognized at a point in time. Conversely, research and development services for each specified indication are performed over time and amounts allocated to these performance obligations are generally recognized over time using a percentage-of-completion method. The Group has determined that research and development expenses provide an appropriate depiction of measure of progress for the research and development services. Changes to estimated cost inputs may result in a cumulative catch-up adjustment. Royalty revenue is recognized as future sales occur as they meet the requirements for the sales-based royalty exception.

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Deferred revenue is recognized if allocated consideration is received in advance of the Group rendering research and development services or earning royalties on future sales. Accounts receivable is recognized based on the terms of the contract and when the Group has an unconditional right to bill the customer, which is generally when research and development services are rendered.

***Research and Development Expenses***

Research and development expenses include the following: (i) research and development costs, which are expensed as incurred; (ii) acquired in-process research and development ("IPR&D") expenses, which include the initial costs of externally developed IPR&D projects, acquired directly in a transaction other than a business combination, that do not have an alternative future use; and (iii) milestone payment obligations for externally developed IPR&D projects incurred prior to regulatory approval of the product in the in-licensed territory, which are accrued when the event requiring payment of the milestone occurs (milestone payment obligations incurred upon regulatory approval are recorded as other intangible assets).

***Collaborative Arrangements***

The Group enters into collaborative arrangements with collaboration partners that fall under the scope of Accounting Standards Codification ("ASC") 808, Collaborative Arrangements ("ASC 808"). The Group records all expenditures for such collaborative arrangements in research and development expenses as incurred, including payments to third party vendors and reimbursements to collaboration partners, if any. Reimbursements from collaboration partners are recorded as reductions to research and development expenses and accrued when they can be contractually claimed.

***Government Grants***

Grants from governments are recognized at their fair values. Government grants that are received in advance are deferred and recognized in the consolidated statements of operations over the period necessary to match them with the costs that they are intended to compensate. Government grants in relation to the achievement of stages of research and development projects are recognized in the consolidated statements of operations when amounts have been received and all attached conditions have been met. Non-refundable grants received without any further obligations or conditions attached are recognized immediately in the consolidated statements of operations. Government grants associated with research and development activities offset research and development expenses and all other grants are recognized to other income.

***Leases***

In an operating lease, a lessee obtains control of only the use of the underlying asset, but not the underlying asset itself. An operating lease is recognized as a right-of-use asset with a corresponding liability at the date which the leased asset is available for use by the Group. The Group recognizes an obligation to make lease payments equal to the present value of the lease payments over the lease term. The lease terms may include options to extend or terminate the lease when it is reasonably certain that the Group will exercise that option.

Lease liabilities include the net present value of the following lease payments: (i) fixed payments; (ii) variable lease payments that depend on an index or a rate; and (iii) payments of penalties for terminating the lease if the lease term reflects the lessee exercising that option, if any. Lease liabilities exclude the following payments that are generally accounted for separately: (i) non-lease components, such as maintenance and security service fees and value added tax, and (ii) any payments that a lessee makes before the lease commencement date. The lease payments are discounted using the interest rate implicit in the lease or if that rate cannot be determined, the lessee's incremental borrowing rate being the rate that the lessee would have to pay to borrow the funds in its currency and jurisdiction necessary to obtain an asset of similar value, economic environment and terms and conditions.

An asset representing the right to use the underlying asset during the lease term is recognized that consists of the initial measurement of the operating lease liability, any lease payments made to the lessor at or before the commencement date less any lease incentives received, any initial direct cost incurred by the Group and any restoration costs.

After commencement of the operating lease, the Group recognizes lease expenses on a straight-line basis over the lease term. The right-of-use asset is subsequently measured at cost less accumulated amortization and any impairment provision. The amortization of the right-of-use asset represents the difference between the straight-line lease expense and the accretion of interest on the lease liability each period. The interest amount is used to accrete the lease liability and to amortize the right-of-use asset. There is no amount recorded as interest expense.

Payments associated with short-term leases are recognized as lease expenses on a straight-line basis over the period of the leases.

Subleases of right-of-use assets are accounted for similar to other leases. As an intermediate lessor, the Group separately accounts for the head-lease and sublease unless it is relieved of its primary obligation under the head-lease. Sublease income is recorded on a gross basis separate from the head-lease expenses. If the total remaining lease cost on the head-lease is more than the anticipated sublease income for the lease term, this is an indicator that the carrying amount of the right-of-use asset associated with the head-lease may not be recoverable, and the right-of-use asset will be assessed for impairment.

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***Income Taxes***

The Group accounts for income taxes under the liability method. Under the liability method, deferred income tax assets and liabilities are determined based on the differences between the financial reporting and income tax bases of assets and liabilities and are measured using the income tax rates that will be in effect when the differences are expected to reverse. A valuation allowance is recorded when it is more likely than not that some of the net deferred income tax asset will not be realized.

The Group accounts for an uncertain tax position in the consolidated financial statements only if it is more likely than not that the position is sustainable based on its technical merits and consideration of the relevant tax authority's widely understood administrative practices and precedents. If the recognition threshold is met, the Group records the largest amount of tax benefit that is greater than 50 percent likely to be realized upon ultimate settlement.

The Group recognizes interest and penalties for income taxes, if any, under income tax payable on its consolidated balance sheets and under other expense in its consolidated statements of operations.

***Earnings per Share***

Basic earnings per share is computed by dividing net income attributable to the Company by the weighted average number of outstanding ordinary shares in issue during the year. Weighted average number of outstanding ordinary shares in issue excludes treasury shares.

Diluted earnings per share is computed by dividing net income attributable to the Company by the weighted average number of outstanding ordinary shares in issue and dilutive ordinary share equivalents outstanding during the year. Dilutive ordinary share equivalents include ordinary shares and treasury shares issuable upon the exercise or settlement of share-based awards issued by the Company using the treasury stock method. The computation of diluted earnings per share does not assume conversion, exercise, or contingent issuance of securities that would have an anti-dilutive effect.

***Segment Reporting***

Operating segments are reported in a manner consistent with the internal reporting provided to the Company chief executive officer who is the Group's chief operating decision maker ("CODM"). The CODM reviews the Group's internal reporting in order to assess performance and allocate resources.

***Profit Appropriation and Statutory Reserves***

The Group's subsidiaries established in the PRC are required to make appropriations to certain non-distributable reserve funds.

In accordance with the relevant laws and regulations established in the PRC, the Company's subsidiaries registered as wholly-owned foreign enterprises and Chinese domestic companies have to make appropriations from their after-tax profits (as determined under generally accepted accounting principles in the PRC ("PRC GAAP")) to reserve funds including statutory surplus fund and discretionary surplus fund. The appropriation to the statutory surplus fund must be 10% of the after-tax profits as determined under PRC GAAP. Appropriation is not required if the statutory surplus fund has reached 50% of the registered capital of the respective company. Appropriation to the discretionary surplus fund is made at the respective company's discretion.

The use of the statutory surplus fund and discretionary surplus fund is restricted to the offsetting of losses, expansion of production and business operations, or increases to the registered capital of the respective company. All these reserves are not permitted to be transferred to the company as cash dividends, loans or advances, nor can they be distributed except under liquidation.

***Recent Accounting Pronouncements***

**Recently issued accounting pronouncements not yet adopted**

In November 2024, the Financial Accounting Standards Board ("FASB") issued Accounting Standard Update ("ASU") 2024-03, Income Statement—Reporting Comprehensive Income—Expense Disaggregation Disclosures (Subtopic 220-40): Disaggregation of Income Statement Expenses. This ASU requires disclosure, in the notes to the financial statements, of specified information about certain costs and expenses. This ASU will be effective for annual reporting periods beginning after December 15, 2026, and interim reporting periods beginning after December 15, 2027. Early adoption is permitted. This ASU will result in the required additional disclosures being included in the notes to consolidated financial statements, once adopted. The Company is currently evaluating the impact of this ASU and expects to adopt it for the year ending December 31, 2027.

**Recently adopted accounting standards** 

In December 2023, the FASB issued ASU 2023-09, Improvements to Income Tax Disclosures (Topic 740). This ASU requires disaggregated information about a reporting entity's effective tax rate reconciliation as well as additional information on income taxes paid. This ASU is effective on a prospective basis for annual reporting periods beginning after December 15, 2024. The Company adopted this ASU for the year ended December 31, 2025 prospectively, and disclosed additional descriptive information as required under Accounting Standards Codification 740 (Note 26).

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**4. Fair Value Disclosures**

Cash equivalents, short-term investments, accounts receivable, other receivables, amounts due from related parties, accounts payable and other payables are carried at cost, which approximates fair value due to the short-term nature of these financial instruments. Bank borrowings are floating rate instruments and carried at amortized cost, which approximates fair values.

**5. Cash and Cash Equivalents and Short-term Investments**

---

| | | |
|:---|:---|:---|
|  | **December 31,** | **December 31,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| **Cash and Cash Equivalents** |  |  |
| &nbsp;&nbsp;&nbsp;Cash at bank and on hand | 57317 | 84480 |
| &nbsp;&nbsp;&nbsp;Bank deposits maturing in three months or less | 14013 | 69478 |
|  | 71330 | 153958 |
| **Short-term Investments** |  |  |
| &nbsp;&nbsp;&nbsp;Bank deposits maturing over three months (note) | 1295945 | 682152 |
|  | 1367275 | 836110 |

---

Note: The maturities for short-term investments ranged from 91 to 186 days for the years ended December 31, 2025 and 2024 respectively.

Certain cash and bank balances denominated in RMB, US$ and UK Pound Sterling ("£") were deposited with banks in the PRC. The conversion of these balances into foreign currencies is subject to the rules and regulations of foreign exchange control promulgated by the PRC government. Cash and cash equivalents and short-term investments were denominated in the following currencies:

---

| | | |
|:---|:---|:---|
|  | **December 31,** | **December 31,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| US$ | 1327608 | 795566 |
| RMB | 37997 | 37906 |
| Hong Kong dollar ("HK$") | 1456 | 2396 |
| £| 193 | 212 |
| Others | 21 | 30 |
|  | 1367275 | 836110 |

---

**6. Accounts Receivable**

Accounts receivable from contracts with customers consisted of the following:

---

| | | |
|:---|:---|:---|
|  | **December 31,** | **December 31,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Accounts receivable — third parties | 126529 | 155155 |
| Accounts receivable — related parties (Note 25(ii)) | 224 | 452 |
| Allowance for credit losses | (3) | (70) |
| Accounts receivable, net | 126750 | 155537 |

---

Substantially all accounts receivable are denominated in RMB, US$ and HK$ and are due within one year from the end of the reporting periods. The carrying values of accounts receivable approximate their fair values due to their short-term maturities.

An aging analysis for accounts receivable — third parties based on the relevant invoice dates is as follows:

---

| | | |
|:---|:---|:---|
|  | **December 31,** | **December 31,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Not later than 3 months | 110416 | 138695 |
| Between 3 months to 6 months | 8764 | 9914 |
| Between 6 months to 1 year | 5948 | 5418 |
| Later than 1 year | 1401 | 1128 |
| Accounts receivable — third parties | 126529 | 155155 |

---

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Movements on the allowance for credit losses:

---

| | | | |
|:---|:---|:---|:---|
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| As at January 1 | 70 | 171 | 60 |
| Increase in allowance for credit losses | 3 | 70 | 141 |
| Decrease in allowance due to subsequent collection | (78) | (168) | (16) |
| Exchange difference | 8 | (3) | (7) |
| Divestment of subsidiaries |  |  | (7) |
| As at December 31 | 3 | 70 | 171 |

---

**7. Other Receivables, Prepayments and Deposits**

Other receivables, prepayments and deposits consisted of the following:

---

| | | |
|:---|:---|:---|
|  | **December 31,** | **December 31,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Prepayments | 8339 | 7924 |
| Interest receivables | 6095 | 2741 |
| Value-added tax ("VAT") receivables | 4567 | 3297 |
| Purchase rebates | 1142 | 782 |
| Deposits | 998 | 1081 |
| Others | 632 | 784 |
|  | 21773 | 16609 |

---

No allowance for credit losses has been made for other receivables, prepayments and deposits for the years ended December 31, 2025 and 2024.

**8. Inventories**

Inventories, net of provision for excess and obsolete inventories, consisted of the following:

---

| | | |
|:---|:---|:---|
|  | **December 31,** | **December 31,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Raw materials | 22451 | 24349 |
| Finished goods | 18678 | 26051 |
|  | 41129 | 50400 |

---

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**9. Property, Plant and Equipment**

Property, plant and equipment consisted of the following:

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **Buildings** | **Leasehold<br> improvements** | **Plant and<br> equipment** | **Furniture and<br> fixtures, other<br> equipment and<br> motor vehicles** | **Construction<br> in progress** | **Total** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Cost |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;As at January 1, 2025 | 58344 | 18157 | 26093 | 41953 | 7268 | 151815 |
| &nbsp;&nbsp;&nbsp;Additions |  | 6 | 62 | 2251 | 7607 | 9926 |
| &nbsp;&nbsp;&nbsp;Disposals |  | (97) |  | (670) |  | (767) |
| &nbsp;&nbsp;&nbsp;Transfers |  | 8166 | 1758 | 4078 | (14002) |  |
| &nbsp;&nbsp;&nbsp;Exchange differences | 2752 | 971 | 1279 | 1945 | 211 | 7158 |
| &nbsp;&nbsp;&nbsp;As at December 31, 2025 | 61096 | 27203 | 29192 | 49557 | 1084 | 168132 |
| Accumulated depreciation and impairment |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;As at January 1, 2025 | 5148 | 16214 | 9723 | 28232 |  | 59317 |
| &nbsp;&nbsp;&nbsp;Depreciation | 2988 | 1783 | 1997 | 5230 |  | 11998 |
| &nbsp;&nbsp;&nbsp;Impairment |  |  | 54 | 35 |  | 89 |
| &nbsp;&nbsp;&nbsp;Disposals |  | (97) |  | (663) |  | (760) |
| &nbsp;&nbsp;&nbsp;Exchange differences | 309 | 722 | 502 | 1332 |  | 2865 |
| &nbsp;&nbsp;&nbsp;As at December 31, 2025 | 8445 | 18622 | 12276 | 34166 |  | 73509 |
| Net book value |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;As at December 31, 2025 | 52651 | 8581 | 16916 | 15391 | 1084 | 94623 |

---

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **Buildings** | **Leasehold<br> improvements** | **Plant and<br> equipment** | **Furniture and<br> fixtures, other<br> equipment and<br> motor vehicles** | **Construction <br> in progress** | **Total** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Cost |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;As at January 1, 2024 | 56722 | 17852 | 23484 | 39817 | 8421 | 146296 |
| &nbsp;&nbsp;&nbsp;Additions |  | 96 | 669 | 1696 | 7932 | 10393 |
| &nbsp;&nbsp;&nbsp;Disposals |  |  | (48) | (762) |  | (810) |
| &nbsp;&nbsp;&nbsp;Transfers | 3256 | 673 | 2700 | 2265 | (8894) |  |
| &nbsp;&nbsp;&nbsp;Exchange differences | (1634) | (464) | (712) | (1063) | (191) | (4064) |
| &nbsp;&nbsp;&nbsp;As at December 31, 2024 | 58344 | 18157 | 26093 | 41953 | 7268 | 151815 |
| Accumulated depreciation and impairment |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;As at January 1, 2024 | 2270 | 15168 | 5463 | 23668 |  | 46569 |
| &nbsp;&nbsp;&nbsp;Depreciation | 3002 | 1278 | 2505 | 5285 |  | 12070 |
| &nbsp;&nbsp;&nbsp;Impairment |  | 171 | 2012 | 732 |  | 2915 |
| &nbsp;&nbsp;&nbsp;Disposals |  |  | (42) | (758) |  | (800) |
| &nbsp;&nbsp;&nbsp;Exchange differences | (124) | (403) | (215) | (695) |  | (1437) |
| &nbsp;&nbsp;&nbsp;As at December 31, 2024 | 5148 | 16214 | 9723 | 28232 |  | 59317 |
| Net book value |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;As at December 31, 2024 | 53196 | 1943 | 16370 | 13721 | 7268 | 92498 |

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**10. Leases**

Leases consisted of the following:

---

| | | |
|:---|:---|:---|
|  | **December 31,** | **December 31,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Right-of-use assets |  |  |
| &nbsp;&nbsp;&nbsp;Offices (note) | 2742 | 4180 |
| &nbsp;&nbsp;&nbsp;Others | 285 | 317 |
| Total right-of-use assets | 3027 | 4497 |
| Lease liabilities, current portion | 2881 | 2925 |
| Lease liabilities, non-current portion | 1852 | 4089 |
| Total lease liabilities | 4733 | 7014 |

---

Note: Includes US$0.6 million right-of-use assets for corporate office in Hong Kong leased through May 2027 in which the contract has a termination option with 1-month advance notice. The termination option was not recognized as part of the right-of-use asset and lease liability as it is uncertain that the Group will exercise such option.

Lease activities are summarized as follows:

---

| | | |
|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Lease expenses: |  |  |
| &nbsp;&nbsp;&nbsp;Short-term leases with lease terms equal or less than 12 months | 2018 | 208 |
| &nbsp;&nbsp;&nbsp;Leases with lease terms greater than 12 months | 2010 | 4541 |
| &nbsp;&nbsp;&nbsp;Impairment |  | 1889 |
|  | 4028 | 6638 |
| Cash paid on lease liabilities | 3234 | 5089 |
| Non-cash: Lease liabilities recognized from obtaining right-of-use assets | 669 | 5356 |
| Non-cash: Lease liabilities changed in relation to modifications and terminations | (47) | (160) |

---

Lease contract terms range for a period of 1 to 8 years. The weighted average remaining lease term and the weighted average discount rate as at December 31, 2025 was 1.91 years and 3.27% respectively. The weighted average remaining lease term and the weighted average discount rate as at December 31, 2024 was 2.54 years and 3.25% respectively.

Future lease payments are as follows:

---

| | |
|:---|:---|
|  | **December 31,<br> 2025** |
|  | **(in US$'000)** |
| Lease payments: |  |
| &nbsp;&nbsp;&nbsp;Not later than 1 year | 2984 |
| &nbsp;&nbsp;&nbsp;Between 1 to 2 years | 1459 |
| &nbsp;&nbsp;&nbsp;Between 2 to 3 years | 275 |
| &nbsp;&nbsp;&nbsp;Between 3 to 4 years | 118 |
| &nbsp;&nbsp;&nbsp;Between 4 to 5 years | 44 |
| Total lease payments | 4880 |
| Less: Discount factor | (147) |
| Total lease liabilities | 4733 |

---

46 / 69

**11. Investment in Equity Investees**

Investment in equity investees mainly consisted of the following:

---

| | | |
|:---|:---|:---|
|  | **December 31,** | **December 31,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| SHPL (note (a)) | 5140 | 77765 |
| ImageneBio, Inc. (note (b)) | 5725 |  |
|  | 10865 | 77765 |

---

Notes:

(a) SHPL
 is a private company with no quoted market price available for its shares. On April 25,
 2025, the Group completed transactions to divest 45% of its 50% shareholding in SHPL (Note
 22).

(b) ImageneBio, Inc.
 ("ImageneBio") is listed on NASDAQ and their shares were acquired by the Group in July 2025
 as a result of the merger completed between Inmagene Biopharmaceuticals ("Inmagene")
 and Ikena Oncology, Inc. ("Ikena") (Note 12).

Summarized financial information for SHPL is as follows:

**(i)** **Summarized balance sheets** 

---

| | | |
|:---|:---|:---|
|  | **December 31,** | **December 31,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Current assets | 235728 | 213707 |
| Non-current assets | 66111 | 67561 |
| Current liabilities | (202622) | (126154) |
| Non-current liabilities | (4965) | (3858) |
| Net assets | 94252 | 151256 |

---

**(ii)** **Summarized statements of operations** 

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Revenue | 422902 | 393525 | 385483 |
| Gross profit | 310272 | 286524 | 284361 |
| Interest income | 816 | 768 | 754 |
| Profit before taxation | 116535 | 109586 | 112488 |
| Income tax expense (note (a)) | (18733) | (15880) | (17636) |
| Net income (note (b)) | 97802 | 93706 | 94852 |

---

Notes:

(a) The
 main entity within the SHPL group has been granted the High and New Technology Enterprise
 ("HNTE") status. Accordingly, the entity was eligible to use a preferential income
 tax rate of 15% for the years ended December 31, 202 5,
 2024 and 2023.

(b) Net
 income is before elimination of unrealized profits on transactions with the Group. The amounts
 eliminated were approximately US$624,000 , US$384,000,
 and US$131,000 for the years ended December 31, 2025, 2024 and 2023 respectively.

47 / 69

**(iii)** **Reconciliation of summarized financial information** 

Reconciliation of the summarized financial information presented to the carrying amount of the investment in SHPL is as follows:

---

| | | | |
|:---|:---|:---|:---|
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Opening net assets as at January 1 | 151256 | 91628 | 141433 |
| Net income | 97802 | 93706 | 94852 |
| Dividends declared | (157274) | (29587) | (146974) |
| Deemed distribution |  | (690) |  |
| Other comprehensive income/(loss) | 2468 | (3801) | 2317 |
| Closing net assets as at December 31 | 94252 | 151256 | 91628 |
| Group's share of net assets | 4713 | 75628 | 45814 |
| Discounting on dividend payable | 172 |  |  |
| Goodwill | 285 | 2718 | 2795 |
| Elimination of unrealized profits on downstream sales | (30) | (581) | (198) |
| Carrying amount of investment as at December 31 | 5140 | 77765 | 48411 |

---

**12. Investment in Equity Security**

In January 2021, the Group and Inmagene entered into a strategic partnership agreement for Inmagene to further develop and fund novel preclinical drugs candidates discovered by the Group for the potential treatment of multiple immunological diseases. Under the terms of the agreement, the Group granted Inmagene exclusive options to four drug candidates. Exercise of the options will grant Inmagene the right to further develop, manufacture and commercialize the exercised specific drug candidates worldwide, with the Group retaining first right to co-commercialization in mainland China.

In July 2024, Inmagene exercised options on two drug candidates (IMG-004 and IMG-007), and the Group received 140,636,592 Inmagene ordinary shares representing approximately 7.5% of Inmagene's issued shares at the time. The shares were recorded as a financial asset at an initial carrying value of US$5.0 million, which was its then fair value estimated using the discounted cash flow method. The exclusive options for the remaining two drug candidates were terminated/expired.

In July 2025, Inmagene announced it had completed a merger with Ikena and the merged company is listed on the NASDAQ as ImageneBio. ImageneBio will be primarily focused on the development of IMG-007, a monoclonal antibody targeting OX-40 licensed from the Group. Inmagene's remaining assets including IMG-004, a non-covalent, reversible small molecule inhibitor targeting Bruton Tyrosine Kinase licensed from the Group, were spun out to Miragene Co ("Miragene"), a new private company. As a result of the merger, the Group's investment in equity security (140,636,592 Inmagene ordinary shares) was exchanged for 429,082 shares in ImageneBio representing a 3.84% equity interest and 7,960,562 shares in Miragene representing a 9.39% equity interest. The entire US$5.0 million carrying value of Inmagene was assigned to ImageneBio and was further marked-to-market to US$7.0 million based on the public trading price as at the merger date, resulting in a gain of US$2.0 million (Note 24). The value attributable to Miragene was considered negligible in consideration of the development progress and risk of the assets. The Group has significant influence in both ImageneBio and Miragene since the Group has a director on both companies' board of directors. As such, the equity interests in ImageneBio (Note 11) and Miragene are subsequently accounted for as investment in equity investees.

**13. Accounts Payable**

---

| | | |
|:---|:---|:---|
|  | **December 31,** | **December 31,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Accounts payable—third parties | 45533 | 42521 |

---

Substantially all accounts payable are denominated in HK$, RMB and US$ and due within one year from the end of the reporting period. The carrying values of accounts payable approximate their fair values due to their short-term maturities.

An aging analysis for accounts payable—third parties based on the relevant invoice dates is as follows:

---

| | | |
|:---|:---|:---|
|  | **December 31,** | **December 31,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Not later than 3 months | 38944 | 37805 |
| Between 3 months to 6 months | 5080 | 2638 |
| Between 6 months to 1 year | 502 | 833 |
| Later than 1 year | 1007 | 1245 |
| Accounts payable—third parties | 45533 | 42521 |

---

48 / 69

**14. Other Payables and Accruals**

Other payables and accruals consisted of the following:

---

| | | |
|:---|:---|:---|
|  | **December 31,** | **December 31,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Accrued research and development expenses | 116359 | 153978 |
| Accrued salaries and benefits | 29074 | 29751 |
| Accrued administrative and other general expenses | 16664 | 14046 |
| Accrued capital expenditures | 11590 | 15858 |
| Accrued selling and marketing expenses | 10976 | 14705 |
| Provision for other taxes and surcharges | 5510 |  |
| Amounts due to related parties (Note 25(ii)) | 1918 | 2016 |
| Deferred government grants | 1764 | 6004 |
| Deposits | 1678 | 1627 |
| Advances for inventory purchases | 250 | 5663 |
| Others | 13109 | 12476 |
|  | 208892 | 256124 |

---

**15. Bank Borrowings**

Bank borrowings consisted of the following:

---

| | | |
|:---|:---|:---|
|  | **December 31,** | **December 31,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Current | 24971 | 23372 |
| Non-current | 68189 | 59434 |
|  | 93160 | 82806 |

---

The weighted average interest rate for outstanding bank borrowings for the years ended December 31, 2025 and 2024 was 2.73% per annum and 3.02% per annum respectively. The carrying amounts of the Group's outstanding bank borrowings as at December 31, 2025 and 2024 were denominated in RMB.

**(i) Short-term working capital loan facility**

In October 2025, a bank extended a short-term unsecured working capital loan facility to a subsidiary in the amount of US$28,462,000 (RMB200,000,000) with an annual interest rate at the 1-year China Loan Prime Rate ("LPR") less 0.89%. As at December 31, 2025, US$20,228,000 (RMB142,142,000) was drawn from the facility.

In October 2024, the subsidiary entered into a short-term unsecured working capital loan facility with the bank in the amount of US$40,769,000 (RMB300,000,000) with an annual interest rate at the 1-year China LPR less 0.82%. As at December 31, 2024, US$22,167,000 (RMB163,119,000) was drawn from the facility.

49 / 69

**(ii) 10-year fixed asset loan facility**

In October 2021, a subsidiary entered into a 10-year fixed asset loan facility agreement with the bank for the provision of a secured credit facility in the amount of US$107,425,000 (RMB754,880,000) with an annual interest rate at the 5-year China LPR less 0.8% (which was supplemented in June 2022) and interest payments commencing upon completion of the underlying construction in progress. This credit facility is guaranteed by the immediate holding company of the subsidiary and secured by the underlying leasehold land and buildings (Shanghai manufacturing facility). For the years ended December 31, 2025 and 2024, US$1,479,000 (RMB10,390,000) and nil were repaid respectively, and cannot be further drawn from the facility. The outstanding bank borrowings were US$72,932,000 (RMB512,496,000) and US$60,639,000 (RMB446,212,000) as at December 31, 2025 and 2024 respectively.

For the years ended December 31, 2025 and 2024, nil and US$44,000 interest was capitalized respectively.

The Group's bank borrowings are repayable as from the dates indicated as follows:

---

| | | |
|:---|:---|:---|
|  | **December 31,** | **December 31,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Not later than 1 year | 24971 | 23372 |
| Between 1 to 3 years | 14153 | 6426 |
| Between 3 to 4 years | 14572 | 8033 |
| Between 4 to 5 years | 15405 | 12049 |
| Later than 5 years | 24059 | 32926 |
|  | 93160 | 82806 |

---

As at December 31, 2025 and 2024, the Group had aggregate unutilized bank borrowing facilities of US$41,248,000 and US$60,549,000 respectively.

**16. Other Non-current Liabilities**

Other non-current liabilities consisted of the following:

---

| | | |
|:---|:---|:---|
|  | **December 31,** | **December 31,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Provision for profit guarantee (Note 22) | 79957 |  |
| Others | 9350 | 4219 |
|  | 89307 | 4219 |

---

**17. Commitments and Contingencies**

The Group had the following capital commitments:

---

| | |
|:---|:---|
|  | **December 31, 2025** |
|  | **(in US$'000)** |
| Property, plant and equipment |  |
| &nbsp;&nbsp;&nbsp;Contracted but not provided for | 692 |

---

The Group does not have any other significant commitments or contingencies.

**18. Ordinary Shares**

As at December 31, 2025, the Company is authorized to issue 1,500,000,000 ordinary shares.

Each ordinary share is entitled to one vote. The holders of ordinary shares are also entitled to receive dividends whenever funds are legally available and when declared by the Board of Directors of the Company.

50 / 69

**19. Share-based Compensation**

**(i)** **Share-based Compensation of the Company** 

The Company conditionally adopted a share option scheme on April 24, 2015 (as amended on April 27, 2020) (the "HUTCHMED Share Option Scheme"). Pursuant to the HUTCHMED Share Option Scheme, the Board of Directors of the Company may, at its discretion, offer any employees and directors (including Executive and Non-executive Directors but excluding Independent Non-executive Directors) of the Company, holding companies of the Company and any of their subsidiaries or affiliates, and subsidiaries or affiliates of the Company share options to subscribe for shares of the Company.

As at December 31, 2025, the aggregate number of shares issuable under the HUTCHMED Share Option Scheme was 39,614,248 ordinary shares. The Company will issue new shares to satisfy share option exercises. Additionally, the number of shares authorized but unissued was 627,672,380 ordinary shares.

Share options granted are generally subject to a four-year vesting schedule, depending on the nature and the purpose of the grant. Share options subject to the four-year vesting schedule, in general, vest 25% upon the first anniversary of the vesting commencement date as defined in the grant letter, and 25% every subsequent year. However, certain share option grants may have a different vesting schedule as approved by the Board of Directors of the Company. No outstanding share options will be exercisable or subject to vesting after the expiry of a maximum of ten years from the date of grant.

A summary of the Company's share option activity and related information is as follows:

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **Number of <br> share options** | **Weighted<br> average exercise<br> price in US$ per share** | **Weighted<br> average remaining<br> contractual<br> life (years)** | **Aggregate<br> intrinsic<br> value<br> (in US$'000)** |
| **Outstanding at January 1, 2024** | 29536655 | 4.57 | 6.67 | 9924 |
| Granted (note (a)) | 2965328 | 3.69 |  |  |
| Exercised | (344825) | 2.29 |  |  |
| Cancelled | (892600) | 4.38 |  |  |
| Expired | (1624285) | 5.23 |  |  |
| **Outstanding at December 31, 2024** | 29640273 | 4.47 | 5.99 | 3804 |
| Granted (note (b)) | 1493435 | 3.27 |  |  |
| Exercised | (726525) | 2.17 |  |  |
| Cancelled | (1423610) | 2.33 |  |  |
| Expired | (3309340) | 4.46 |  |  |
| **Outstanding at December 31, 2025** | 25674233 | 4.59 | 5.12 | 1424 |
| **Vested and exercisable at December 31, 2024** | 21186120 | 4.92 | 5.13 | 1387 |
| **Vested and exercisable at December 31, 2025** | 20020945 | 4.94 | 4.23 | 953 |

---

Notes:

(a) Includes
 aggregate 2,765,328 share options granted to an executive director. 1,359,561 share options
 were granted in March 2024 and 1,405,767 share options were granted in August 2024
 where the number of share options exercisable is subject to certain performance targets based
 on a market condition covering the 3-year periods from 2023 to 2025 and from 2024 to 2026
 respectively which has been reflected in estimating the grant date fair value using the Monte
 Carlo simulation model. The grant date fair value of such awards are US$1.29 and US$1.24
 per share respectively. Vesting of such awards will occur in around March 2026 and March 2027
 respectively if the performance targets are met.

(b) This
 was granted to an executive director in June 2025 where the number of share options
 exercisable is subject to certain performance targets based on a market condition covering
 the 3-year period from 2025 to 2027 which has been reflected in estimating the grant date
 fair value using the Monte Carlo simulation model. The grant date fair value of such award
 is US$1.17 per share. Vesting of such award will occur around March 2028 if the performance
 targets are met.

In estimating the fair value of share options granted, the following assumptions were used in the Monte Carlo simulation model for the awards that are subject to certain performance targets based on a market condition and Polynomial model for other options granted in the periods indicated:

---

| | | |
|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** |
| Weighted average grant date fair value of share options (in US$ per share) | 1.17 | 1.29 |
| Significant inputs into the valuation model (weighted average): |  |  |
| &nbsp;&nbsp;&nbsp;Exercise price (in US$ per share) | 3.27 | 3.69 |
| &nbsp;&nbsp;&nbsp;Share price at effective date of grant (in US$ per share) | 3.27 | 3.69 |
| &nbsp;&nbsp;&nbsp;Expected volatility (note (a)) | 56.62% | 54.69% |
| &nbsp;&nbsp;&nbsp;Risk-free interest rate (note (b)) | 4.52% | 3.86% |
| &nbsp;&nbsp;&nbsp;Contractual life of share options (in years) | 10 | 10 |
| &nbsp;&nbsp;&nbsp;Expected dividend yield (note (c)) | 0% | 0% |

---

Notes:

(a) The
 Company calculated its expected volatility with reference to the historical volatility prior
 to the issuances of share options.

(b) The
 risk-free interest rates reference the US Treasury yield curves.

(c) The
 Company has not declared or paid any dividends and does not currently expect to do so prior
 to the exercise of the granted share options, and therefore uses an expected dividend yield
 of zero in the valuation models.

51 / 69

The Company will issue new shares to satisfy share option exercises. The following table summarizes the Company's share option exercises:

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Cash received from share option exercises | 1578 | 790 | 5094 |
| Total intrinsic value of share option exercises | 663 | 476 | 4626 |

---

The Group recognizes compensation expense on a graded vesting approach over the requisite service period. The following table presents share-based compensation expense included in the Group's consolidated statements of operations:

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Research and development expenses | 1982 | 1970 | 3250 |
| Selling and administrative expenses | 441 | 1042 | 2843 |
| Cost of revenue | 90 | 57 | 91 |
|  | 2513 | 3069 | 6184 |

---

As at December 31, 2025, the total unrecognized compensation cost was US$2,689,000, and will be recognized on a graded vesting approach over the weighted average remaining service period of 1.69 years.

**(ii)** **LTIP** 

The Company grants awards under the LTIP to participating directors and employees, giving them a conditional right to receive ordinary shares of the Company or the equivalent ADS (collectively the "Awarded Shares") to be purchased by the Trustee up to a cash amount excluding any cash elected payments. Vesting will depend upon continued employment of the award holder with the Group and will otherwise be at the discretion of the Board of Directors of the Company. Additionally, some awards are subject to change based on annual performance targets prior to their determination date.

*LTIP awards prior to the determination date*

Performance targets vary by award, and may include targets for shareholder returns, revenue and profitability. As the extent of achievement of the performance targets is uncertain prior to the determination date, a probability based on management's assessment on the achievement of the performance target has been assigned to calculate the amount to be recognized as an expense over the requisite period with a corresponding entry to liability.

*LTIP awards after the determination date*

Upon the determination date, based on the actual achievement of performance target, the amount previously recorded in the liability will be adjusted through share-based compensation expense. The Company will pay a determined monetary amount, up to the maximum cash amount based on the actual achievement of the performance target specified in the award, to the Trustee to purchase the Awarded Shares. Any cumulative compensation expense previously recognized as a liability will be transferred to additional paid-in capital.

Granted awards under the LTIP are as follows:

---

| | | | |
|:---|:---|:---|:---|
| <br>**Grant date** | **Maximum cash amount**<br>**(in US$ millions)** | **Covered**<br>**financial years** | **Performance target**<br>**determination date** |
| March 13, 2024 | 0.7 | note (a) | note (a) |
| August 5, 2024 | 19.3 | 2024-2026 | note (b) |
| August 5, 2024 | 0.3 | note (c) | note (c) |
| June 9, 2025 | 20.0 | 2025-2027 | note (d) |

---

52 / 69

Notes:

(a) This
 award does not stipulate performance targets and is subject to a vesting schedule of 25%
 on each of the first, second, third and fourth anniversaries of the date of grant.

(b) The
 annual performance target determination dates are the dates of the announcements of the Group's
 annual results for the financial years ending December 31, 2024, 2025 and 2026. Vesting
 occurs in 2027, three weeks after the date of completion of the share purchase for the awards
 for the financial year ending December 31, 2026.

(c) This
 award does not stipulate performance targets and is subject to a vesting schedule of 50%
 on the first and second anniversaries of the date of grant.

(d) The
 annual performance targets determination dates are the dates of the announcements of the
 Group's annual results for the financial years ending December 31, 2025, 2026
 and 2027. Vesting occurs in 2028, three weeks after the date of completion of the share purchase
 for the awards for the financial year ending December 31, 2027.

The Trustee has been set up solely for the purpose of purchasing and holding the Awarded Shares during the vesting period on behalf of the Company using funds provided by the Company. On the determination date, if any, the Company will determine the cash amount, based on the actual achievement of each annual performance target, for the Trustee to purchase the Awarded Shares. The Awarded Shares will then be held by the Trustee until they are vested.

The Trustee's assets include treasury shares and funds for additional treasury shares, trustee fees and expenses. The number of treasury shares (in ordinary shares equivalent) held by the Trustee were as follows:

---

| | | |
|:---|:---|:---|
|  | **Number of<br> treasury shares** | **Cost<br> (in US$'000)** |
| As at January 1, 2024 | 17612685 | 66987 |
| Purchased | 10259133 | 36064 |
| Vested | (11154360) | (42127) |
| As at December 31, 2024 | 16717458 | 60924 |
| Vested | (4134157) | (15442) |
| As at December 31, 2025 | 12583301 | 45482 |

---

Based on the estimated achievement of performance conditions relating to annual results for the financial year ended December 31, 2025, the determined monetary amount for LTIP awards was US$3,760,000 which is recognized to share-based compensation expense over their requisite vesting period.

For the years ended December 31, 2025 and 2024, US$6,085,000 and US$12,632,000 of the LTIP awards were forfeited respectively based on the determined or estimated monetary amount as at the forfeiture date.

The following table presents the share-based compensation expenses recognized under the LTIP awards:

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Research and development expenses | 8201 | 12098 | 18224 |
| Selling and administrative expenses | 3972 | 6028 | 11690 |
| Cost of revenue | 606 | 414 | 502 |
|  | 12779 | 18540 | 30416 |
| Recorded with a corresponding credit to: |  |  |  |
| Liability | 1770 | 3710 | 11364 |
| Additional paid-in capital | 11009 | 14830 | 19052 |
|  | 12779 | 18540 | 30416 |

---

For the years ended December 31, 2025, 2024 and 2023, US$751,000, US$12,424,000 and US$4,563,000 were reclassified from liability to additional paid-in capital respectively upon LTIP awards reaching the determination date. As at December 31, 2025 and 2024, US$2,406,000 and US$1,443,000 were recorded in liabilities respectively.

As at December 31, 2025, the total unrecognized compensation cost was approximately US$7,002,000, which considers expected performance targets and the amounts expected to vest, and will be recognized over the requisite periods.

**20. Revenue**

The following table presents revenue disaggregated by contract type:

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31, 2025** | **Year Ended December 31, 2025** | **Year Ended December 31, 2025** |
|  | **Oncology/<br> Immunology** | **Other Ventures** | **Total** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Invoiced Goods — Marketed Products | 100637 |  | 100637 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— Distribution |  | 262973 | 262973 |
| Services — Commercialization of Marketed Products | 45300 |  | 45300 |
| License & Collaborations — Services | 27904 |  | 27904 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— Royalties | 68419 |  | 68419 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— Licensing | 12090 |  | 12090 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— Manufacturing supply | 31189 |  | 31189 |
|  | 285539 | 262973 | 548512 |
| Third parties | 285539 | 261651 | 547190 |
| Related parties (Note 25(i)) |  | 1322 | 1322 |
|  | 285539 | 262973 | 548512 |

---

53 / 69

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31, 2024** | **Year Ended December 31, 2024** | **Year Ended December 31, 2024** |
|  | **Oncology/<br> Immunology** | **Other Ventures** | **Total** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Invoiced Goods — Marketed Products | 128008 |  | 128008 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— Distribution |  | 266836 | 266836 |
| Services — Commercialization of Marketed Products | 52485 |  | 52485 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— Research and development | 471 |  | 471 |
| License & Collaborations — Services | 57968 |  | 57968 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— Royalties | 71041 |  | 71041 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— Licensing | 43000 |  | 43000 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— Manufacturing supply | 10392 |  | 10392 |
|  | 363365 | 266836 | 630201 |
| Third parties | 362894 | 262982 | 625876 |
| Related parties (Note 25(i)) | 471 | 3854 | 4325 |
|  | 363365 | 266836 | 630201 |

---

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31, 2023** | **Year Ended December 31, 2023** | **Year Ended December 31, 2023** |
|  | **Oncology/ Immunology** | **Other Ventures** | **Total** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Invoiced Goods — Marketed Products | 83087 |  | 83087 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— Distribution |  | 309383 | 309383 |
| Services — Commercialization of Marketed Products | 48608 |  | 48608 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— Research and development | 481 |  | 481 |
| License & Collaborations — Services | 80397 |  | 80397 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— Royalties | 32470 |  | 32470 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— Licensing | 278855 |  | 278855 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— Manufacturing supply | 4718 |  | 4718 |
|  | 528616 | 309383 | 837999 |
| Third parties | 528135 | 301119 | 829254 |
| Related parties (Note 25(i)) | 481 | 8264 | 8745 |
|  | 528616 | 309383 | 837999 |

---

The following table presents liability balances from contracts with customers:

---

| | | |
|:---|:---|:---|
|  | **December 31,** | **December 31,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Deferred revenue |  |  |
| &nbsp;&nbsp;&nbsp;Current — Oncology/Immunology segment (note (a)) | 31362 | 50007 |
| &nbsp;&nbsp;&nbsp;Current — Other Ventures segment (note (b)) | 53 | 64 |
|  | 31415 | 50071 |
| &nbsp;&nbsp;&nbsp;Non-current — Oncology/Immunology segment (note (a)) | 20132 | 48432 |
| Total deferred revenue (note (c) and (d)) | 51547 | 98503 |

---

Notes:

(a) Oncology/ Immunology
 segment deferred revenue relates to unamortized upfront and milestone payments, invoiced
 amounts for royalties where the customer has not yet completed the in-market sale and advance
 consideration received for cost reimbursements which are attributed to research and development
 services that have not yet been rendered as at the reporting date.

(b) Other
 Ventures segment deferred revenue relates to payments in advance from customers for goods
 that have not been transferred and services that have not been rendered to the customer as
 at the reporting date.

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(c) Estimated
 deferred revenue to be recognized over time as from the date indicated is as follows:

---

| | | |
|:---|:---|:---|
|  | **December 31,** | **December 31,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Not later than 1 year | 31415 | 50071 |
| Between 1 to 2 years | 11314 | 39288 |
| Between 2 to 3 years | 4666 | 4084 |
| Between 3 to 4 years | 859 | 1095 |
| Later than 4 years | 3293 | 3965 |
|  | 51547 | 98503 |

---

(d) As
 at January 1, 202 5, deferred revenue was US$98.5 million,
 of which US$59.0 million was recognized during the year ended December 31, 2025.

***License and collaboration agreement with Takeda Pharmaceuticals***

On January 23, 2023 (as amended in June 2025), the Group and Takeda Pharmaceuticals International AG ("Takeda") entered into an exclusive out-licensing agreement (the "Takeda Agreement") in territories outside of Mainland China, Hong Kong and Macau (the "Territory") to further the global development, commercialization and manufacturing of Fruzaqla, also known as fruquintinib, a targeted oncology therapy for the treatment of various types of solid tumors. Under the terms of the Takeda Agreement, the Group is entitled to receive a series of payments up to US$1.1 billion, including upfront, regulatory, development and commercial sales milestone payments, plus royalties on net sales in the Territory. Fruzaqla was successfully approved for commercialization in the US in November 2023, which triggered a regulatory approval milestone of US$35 million. For the year ended December 31, 2024, Takeda has delivered over US$200 million in net sales of Fruzaqla, which triggered a commercial sales milestone of US$20 million. Following the regulatory and first pricing approval of Fruzaqla in Japan in November 2024 and the regulatory approval and the first national reimbursement recommendation in Europe in December 2024, regulatory approval milestone payments of US$7 million and US$10 million were triggered respectively.

Upfront and cumulative milestone payments according to the Takeda Agreement achieved up to December 31, 2025 are summarized as follows:

---

| | |
|:---|:---|
|  | **(in US$'000)** |
| Upfront payment | 400000 |
| Regulatory approval milestone payments achieved | 52000 |
| Commercial sales milestone payment achieved | 20000 |

---

Note: As of December 31, 2025, US$358.4 million of the upfront payment, US$52.0 million of the regulatory approval milestone payments and US$20.0 million of the commercial sales milestone payment were recognized as revenue, including US$47.5 million, US$2.8 million and nil respectively during the year ended December 31, 2025.

The Takeda Agreement has the following material performance obligations: (1) the licenses for the development and commercialization of Fruzaqla in the Territory and the manufacture of Fruzaqla for use in the Territory, (2) manufacturing supply and (3) services for research and development including ongoing clinical trials and regulatory submissions and manufacturing technology transfer.

The transaction price for these performance obligations includes the upfront payment, service cost reimbursements, milestone payments and sales-based royalties. Milestone payments are not included in the transaction price until they become probable that a significant reversal of revenue would not occur, which is generally when the criteria to receive the specified milestone are achieved.

The allocation of the transaction price to each relevant performance obligation was based on the relative standalone selling price of each performance obligation determined at the inception of the contract. Variable consideration is allocated entirely to a performance obligation or to a distinct good or service that forms part of a single performance obligation if the terms of the variable consideration relate to the satisfaction of the respective performance obligation and the amount allocated is consistent with the amount expected to be received for the satisfaction of the respective performance obligation. The standalone selling price of the licenses for the development and commercialization of Fruzaqla in the Territory and the manufacture of Fruzaqla for use in the Territory and manufacturing supply was determined using a discounted cash flow method based on the probability-weighted present value of forecasted cash flows associated with out-licensing Fruzaqla in the Territory, and the standalone selling price of the services for research and development of ongoing clinical trials, regulatory submissions and manufacturing technology transfer was determined using a cost plus margin approach based on the present value of estimated future service costs plus a reasonable margin. Significant assumptions included in the determination of the standalone selling prices for each performance obligation identified including forecasted revenue, probabilities of regulatory approvals, estimated future service costs, margin rates and discount rates. Based on these estimations, proportionate amounts of transaction price to be allocated to the licenses, and other performance obligations were 62% and 38% respectively at contract inception. Control of the licenses to Fruzaqla was transferred at the inception date of the agreement and consequently, amounts allocated to this performance obligation were recognized at inception. Manufacturing supply is recognized at a point in time when the control of the goods is transferred. Services are performed over the term of the Takeda Agreement and amounts allocated are recognized over time using a percentage-of-completion method. Royalties are recognized as future sales occur as they meet the requirements for the sales-usage based royalty exception.

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Revenue recognized under the Takeda Agreement is as follows:

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Manufacturing supply — Invoiced Marketed Products sales | 45050 | 51378 | 5053 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— Allocated from upfront payment | 31189 | 10392 | 4718 |
| Services — Research and development | 1284 | 18949 | 33892 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— Allocated from upfront and milestone payments | 17538 | 25384 | 28494 |
| Royalties — Marketed Products | 44357 | 39386 | 2092 |
| Licensing — Allocated from upfront and milestone payments | 1640 | 32300 | 278855 |
|  | 141058 | 177789 | 353104 |

---

***License and collaboration agreement with Eli Lilly***

On October 8, 2013, the Group entered into a licensing, co-development and commercialization agreement in China with Eli Lilly and Company ("Lilly") relating to Elunate ("Lilly Agreement"), as the China brand name for fruquintinib. Under the terms of the Lilly Agreement, the Group is entitled to receive a series of payments up to US$86.5 million, including upfront payments and development and regulatory approval milestones. Development costs after the first development milestone are shared between the Group and Lilly. Elunate was successfully commercialized in China in November 2018, and the Group receives tiered royalties in the range of 15% to 20% on all sales in China.

In December 2018, the Group entered into various amendments to the Lilly Agreement (the "2018 Amendment"). Under the terms of the 2018 Amendment, the Group is entitled to determine and conduct future life cycle indications ("LCI") development of Elunate in China beyond the three initial indications specified in the Lilly Agreement and will be responsible for all associated development costs. In return, the Group will receive additional regulatory approval milestones of US$20 million for each LCI approved, for up to three LCI or US$60 million in aggregate, and will increase tiered royalties to a range of 15% to 29% on all Elunate sales in China upon the commercial launch of the first LCI. Additionally, through the 2018 Amendment, Lilly has provided consent, and freedom to operate, for the Group to enter into joint development collaborations with certain third-party pharmaceutical companies to explore combination treatments of Elunate and various immunotherapy agents. The 2018 Amendment also provided the Group rights to promote Elunate in provinces that represent 30% to 40% of the sales of Elunate in China upon the occurrence of certain commercial milestones by Lilly. Such rights were further amended below.

In July 2020, the Group entered into an amendment to the Lilly Agreement (the "2020 Amendment") relating to the expansion of the Group's role in the commercialization of Elunate across all of China. Under the terms of the 2020 Amendment, the Group is responsible for providing promotion and marketing services, including the development and execution of all on-the-ground medical detailing, promotion and local and regional marketing activities, in return for service fees on sales of Elunate made by Lilly. In October 2020, the Group commenced such promotion and marketing services. In addition, development and regulatory approval milestones for an initial indication under the Lilly Agreement were increased by US$10 million in lieu of cost reimbursement.

Upfront and cumulative milestone payments according to the Lilly Agreement achieved up to December 31, 2025 are summarized as follows:

---

| | |
|:---|:---|
|  | **(in US$'000)** |
| Upfront payment | 6500 |
| Development milestone payments achieved | 40000 |

---

The Lilly Agreement has the following performance obligations: (1) the license for the commercialization rights to Elunate and (2) the research and development services for the specified indications. The transaction price includes the upfront payment, research and development cost reimbursements, milestone payments and sales-based royalties. Milestone payments were not included in the transaction price until it became probable that a significant reversal of revenue would not occur, which is generally when the specified milestone is achieved. The allocation of the transaction price to each performance obligation was based on the relative standalone selling prices of each performance obligation determined at the inception of the contract. Based on this estimation, proportionate amounts of transaction price to be allocated to the license to Elunate and the research and development services were 90% and 10% respectively. Control of the license to Elunate transferred at the inception date of the agreement and consequently, amounts allocated to this performance obligation were recognized at inception. Conversely, research and development services for each specified indication are performed over time and amounts allocated are recognized over time using a percentage-of-completion method. Royalties are recognized as future sales occur as they meet the requirements for the sales-usage based royalty exception.

The 2018 Amendment is a separate contract as it added distinct research and development services for the LCIs to the Lilly Agreement. The 2020 Amendment related to the promotion and marketing services is a separate contract as it added distinct services to the Lilly Agreement. Such promotion and marketing services are recognized over time based on amounts that can be invoiced to Lilly. The 2020 Amendment related to the additional development and regulatory approval milestone amounts is a modification as it only affected the transaction price of research and development services for a specific indication under the Lilly Agreement, and therefore, such additional milestone amounts will be included in the transaction price accounted under the Lilly Agreement once the specified milestones are achieved.

56 / 69

Revenue recognized under the Lilly Agreement and subsequent amendments is as follows:

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Goods — Invoiced Marketed Products sales | 16205 | 15826 | 16966 |
| Services — Commercialization of Marketed Products | 45300 | 52485 | 48608 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— Research and development | 31 | 230 | 2828 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— Allocated from upfront and milestone payments |  |  | 12 |
| Royalties — Marketed Products | 15389 | 18022 | 16560 |
|  | 76925 | 86563 | 84974 |

---

***License and collaboration agreement with AstraZeneca***

On December 21, 2011, the Group and AstraZeneca AB (publ) ("AZ") entered into a global licensing, co-development, and commercialization agreement for Orpathys ("AZ Agreement"), also known as savolitinib, a novel targeted therapy and a highly selective inhibitor of the c-Met receptor tyrosine kinase for the treatment of cancer. Under the terms of the AZ Agreement, the Group is entitled to receive a series of payments up to US$140 million, including upfront payments and development and first-sale milestones. Additionally, the AZ Agreement contains possible significant future commercial sale milestones. Development costs for Orpathys in China will be shared between the Group and AZ, with the Group continuing to lead the development in China. AZ will lead and pay for the development of Orpathys for the rest of the world. Orpathys was successfully commercialized in China in July 2021, and the Group receives fixed royalties of 30% based on all sales in China. Should Orpathys be successfully commercialized outside China, the Group would receive tiered royalties from 9% to 13% on all sales outside of China.

In November 2021, the Group entered into an amendment which revised the sharing between the Group and AZ of development costs for Orpathys in China for non-small cell lung cancer ("NSCLC"), as well as adding potential development milestones.

Upfront and cumulative milestone payments according to the AZ Agreement achieved up to December 31, 2025 are summarized as follows:

---

| | |
|:---|:---|
|  | **(in US$'000)** |
| Upfront payment | 20000 |
| Development milestone payments achieved (note) | 57000 |
| First-sale milestone payment achieved | 25000 |

---

Note: In June 2025, a new drug application for savolitinib in combination with osimertinib for the treatment of NSCLC was approved by the China National Medical Products Administration, which triggered a development milestone payment of US$11 million to the Group.

The AZ Agreement has the following performance obligations: (1) the license for the commercialization rights to Orpathys and (2) the research and development services for the specified indications. The transaction price includes the upfront payment, research and development cost reimbursements, milestone payments and sales-based royalties. Milestone payments were not included in the transaction price until it became probable that a significant reversal of revenue would not occur, which is generally when the specified milestone is achieved. The allocation of the transaction price to each performance obligation was based on the relative standalone selling prices of each performance obligation determined at the inception of the contract. Based on this estimation, proportionate amounts of transaction price to be allocated to the license to Orpathys and the research and development services were 95% and 5% respectively. Control of the license to Orpathys transferred at the inception date of the agreement and consequently, amounts allocated to this performance obligation were recognized at inception. Conversely, research and development services for each specified indication are performed over time and amounts allocated are recognized over time using a percentage-of-completion method.

Revenue recognized under the AZ Agreement and subsequent amendments is as follows:

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Goods — Invoiced Marketed Products sales | 9899 | 10874 | 15013 |
| Services — Research and development | 8278 | 13072 | 14993 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; — Allocated from upfront and milestone payments | 773 | 333 | 77 |
| Royalties — Marketed Products | 8673 | 13633 | 13818 |
| Licensing — Allocated from upfront and milestone payments | 10450 | 5700 |  |
|  | 38073 | 43612 | 43901 |

---

57 / 69

**21. Research and Development Expenses**

Research and development expenses are summarized as follows:

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Clinical trial related costs | 80072 | 135652 | 199728 |
| Personnel compensation and related costs | 58317 | 69079 | 93030 |
| Other research and development expenses | 9906 | 7378 | 9243 |
|  | 148295 | 212109 | 302001 |

---

Research and development expenses include expenditures for collaborative arrangements under ASC 808 to evaluate the combination of the Group's drug compounds with the collaboration partners' drug compounds. For the years ended December 31, 2025, 2024 and 2023, the Group has incurred US$3.9 million, US$10.9 million and US$22.0 million respectively, related to such collaborative arrangements.

**22. Gain on Divestment of an Equity Investee**

On April 25, 2025, the Group completed the divestment of an aggregate 45% equity interest out of 50% in SHPL to third parties for cash consideration of US$608.5 million (RMB4.5 billion), including an aggregate 35% equity interest to two China-based private-equity funds ("PE Buyers") and 10% equity interest to the parent company of the existing 50% SHPL joint venture partner. In regard to the sales and purchase agreements with the PE Buyers, they include a profit guarantee clause with contingent payments capped at US$94.6 million (RMB696 million) based on growth targets of SHPL's net income after tax for the 3 years up to 2027. As at December 31, 2025, provision for profit guarantee of US$80.0 million, which was the present value of the estimated profit guarantee to the PE Buyers, was included in other non-current liabilities and reflects interest accretion and foreign exchange. Any subsequent changes to estimated profit guarantee and accretion of the discount on the provision will be recognized in the gain on divestment of an equity investee.

The Group has the rights to nominate one director out of seven on SHPL's board of directors, thus the Group continues to have significant influence and accounts for its remaining 5% equity interest in SHPL using the equity method of accounting.

The gain on divestment of an equity investee was recognized in the consolidated statement of operations as follows:

---

| | |
|:---|:---|
|  | **Year Ended December 31, 2025** |
|  | **(in US$'000)** |
| Proceeds | 608503 |
| Less: Provision for profit guarantee | (71879) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Interest accretion on provision for profit guarantee | (4495) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Carrying amount of 45% equity interest in SHPL | (48680) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Accumulated other comprehensive loss and reserves | (2733) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Transaction costs and others | (3820) |
| Gain on divestment of an equity investee | 476896 |
| Less: Tax expenses | (61133) |
| Gain on divestment of an equity investee, net of tax | 415763 |

---

**23. Government Grants**

Government grants in the Oncology/Immunology segment are primarily given in support of R&D activities and construction projects which are conditional upon i) the Group spending a predetermined amount, regardless of success or failure of the research and development projects and/or ii) the achievement of certain stages of research and development projects being approved by the relevant PRC government authority. They are refundable to the government if the conditions are not met. Government grants in the Other Ventures segment are primarily given to promote local initiatives. These government grants may be subject to ongoing reporting and monitoring by the government over the period of the grant.

Government grants, which are deferred and recognized in the consolidated statements of operations over the period necessary to match them with the costs that they are intended to compensate, are recognized in other payables and accruals (Note 14) and other non-current liabilities. For the years ended December 31, 2025, 2024 and 2023, the Group received government grants of US$12.8 million, US$9.6 million and US$4.1 million respectively.

Government grants were recognized in the consolidated statements of operations as follows:

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Research and development expenses | 6451 | 1256 | 1054 |
| Other income (Note 24) | 8970 | 3095 | 3134 |
|  | 15421 | 4351 | 4188 |

---

58 / 69

**24. Other income/(expense)**

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Other income: |  |  |  |
| &nbsp;&nbsp;&nbsp;Government grants (Note 23) | 8970 | 3095 | 3134 |
| &nbsp;&nbsp;&nbsp;Foreign exchange gains | 4998 | 5060 | 8661 |
| &nbsp;&nbsp;&nbsp;Gain on investment in equity security (Note 12) | 2037 |  |  |
| &nbsp;&nbsp;&nbsp;Others | 3705 | 2119 | 1154 |
|  | 19710 | 10274 | 12949 |
| Other expense: |  |  |  |
| &nbsp;&nbsp;&nbsp;Provision for other taxes and surcharges | (5510) |  |  |
| &nbsp;&nbsp;&nbsp;Impairment of property, plant and equipment | (89) | (2915) | (3678) |
| &nbsp;&nbsp;&nbsp;Impairment of right-of-use assets |  | (1889) | (2088) |
| &nbsp;&nbsp;&nbsp;Others | (168) | (80) | (2636) |
|  | (5767) | (4884) | (8402) |

---

**25. Significant Transactions with Related Parties and Non-Controlling Shareholders of Subsidiaries**

The Group has the following significant transactions with related parties and non-controlling shareholders of subsidiaries, which were carried out in the normal course of business at terms determined and agreed by the relevant parties:

**(i)** **Transactions with related parties:** 

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Sales to: |  |  |  |
| &nbsp;&nbsp;&nbsp;Indirect subsidiaries of CK Hutchison Holdings Limited ("CK Hutchison") |  | 5 | 1914 |
| &nbsp;&nbsp;&nbsp;An equity investee | 1322 | 3849 | 6350 |
|  | 1322 | 3854 | 8264 |
| Revenue from research and development services from: |  |  |  |
| &nbsp;&nbsp;&nbsp;An equity investee |  | 471 | 481 |
| Purchases from: |  |  |  |
| &nbsp;&nbsp;&nbsp;An equity investee | 2168 | 2777 | 3651 |
| Rendering of marketing services from: |  |  |  |
| &nbsp;&nbsp;&nbsp;Indirect subsidiaries of CK Hutchison |  |  | 150 |
| Rendering of management services from: |  |  |  |
| &nbsp;&nbsp;&nbsp;An indirect subsidiary of CK Hutchison | 1109 | 1087 | 997 |
| Divestment of subsidiaries to: |  |  |  |
| &nbsp;&nbsp;&nbsp;An indirect subsidiary of CK Hutchison (note (a)) |  |  | 5103 |

---

**(ii)** **Balances with related parties included in:** 

---

| | | |
|:---|:---|:---|
|  | **December 31,** | **December 31,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Accounts receivable — related parties |  |  |
| &nbsp;&nbsp;&nbsp;An equity investee (note (b)) | 224 | 452 |
| Amounts due from related parties |  |  |
| &nbsp;&nbsp;&nbsp;An equity investee (note (b) and (c)) | 51796 | 7899 |
| Other payables and accruals |  |  |
| &nbsp;&nbsp;&nbsp;Indirect subsidiaries of CK Hutchison (note (d) and (e)) | 1840 | 1928 |
| &nbsp;&nbsp;&nbsp;An equity investee (note (b) and (f)) | 78 | 88 |
|  | 1918 | 2016 |
| Amounts due to related parties (note (g)) |  |  |
| &nbsp;&nbsp;&nbsp;An indirect subsidiary of CK Hutchison (note (e)) | 6251 | 6475 |
| &nbsp;&nbsp;&nbsp;An equity investee (note (f)) | 74 | 142 |
|  | 6325 | 6617 |

---

59 / 69

Notes:

(a) On December 7, 2023, the Group
completed a transaction to divest Hutchison Hain Organic (Hong Kong) Limited and HUTCHMED Science Nutrition Limited to an indirect subsidiary
of CK Hutchison for proceeds of US$5,103,000. A gain on divestment of US$96,000 was recorded in other income for the year ended
December 31, 2023.

(b) Balances with related parties
are unsecured, repayable on demand and interest-free. The carrying values of balances with related parties approximate their fair values
due to their short-term maturities. No allowance for credit losses has been made for amounts due from related parties for the years ended
December 31, 202 5 and 2024.

(c) As at December 31, 2025, dividends receivable of US$51,796,000 (December 31, 2024: US$6,795,000) was included
in amounts due from related parties. As at December 31, 2025, the non-current portion $41,381,000 will be received no later than December
31, 2028.

(d) Amounts due to indirect subsidiaries of CK Hutchison are unsecured, repayable on demand and interest-bearing
if not settled within one month.

(e) As at December 31, 202 5
and 2024, a branding liability payable of US$1,538,000 was included in amounts due to related parties under other payables and accruals.
As at December 31, 2025 and 2024, US$6,251,000 and US$6,475,000 of the branding liability payable was included in amounts due to related
parties respectively.

(f) Includes other deferred income representing amounts recognized from granting of commercial, promotion
and marketing rights.

(g) Amounts due to related parties of US$6,617,000 as at December 31, 2024 was separately presented from other
non-current liabilities on the consolidated balance sheets to conform with current year presentation.

**(iii)** **Transactions with non-controlling shareholders of subsidiaries:** 

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Sales | 51139 | 54532 | 66417 |
| Purchases | 639 | 288 | 5733 |
| Dividends declared |  | 1000 | 9068 |
| Distribution service fee | 22 | 216 | 369 |

---

**(iv)** **Balances with non-controlling shareholders of subsidiaries included in:** 

---

| | | |
|:---|:---|:---|
|  | **December 31,** | **December 31,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Accounts receivable | 11280 | 8084 |
| Accounts payable | 90 | 77 |
| Other payables and accruals | 248 | 427 |

---

60 / 69

**26. Income Taxes**

**(i)** **Income tax expense/(benefit)** 

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Current tax |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;PRC (note (a) and (b)) | 63748 | 1723 | 1767 |
| &nbsp;&nbsp;&nbsp;&nbsp;US and others (note (c)) | (22) | 161 | 471 |
| &nbsp;&nbsp;&nbsp;&nbsp;HK (note (d)) | 2 |  | 45 |
|  | 63728 | 1884 | 2283 |
| Deferred income tax (benefit)/expense |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;PRC (note (a) and (b)) | (492) | 2434 | 2400 |
| &nbsp;&nbsp;&nbsp;&nbsp;US and others | 374 | 2874 | (137) |
| &nbsp;&nbsp;&nbsp;&nbsp;HK |  |  | (37) |
|  | (118) | 5308 | 2226 |
| Income tax expense | 63610 | 7192 | 4509 |

---

Notes:

(a) Taxation
 in the PRC has been provided for at the applicable rate on the estimated assessable profits
 less estimated available tax losses, if any, in relevant entities. Under the PRC Enterprise
 Income Tax Law (the "EIT Law"), the standard enterprise income tax rate is 25%.
 In addition, the EIT Law provides for a preferential tax rate of 15% for companies which
 qualify as HNTE. HUTCHMED Limited and its wholly-owned subsidiary HUTCHMED (Suzhou) Limited
 qualify as HNTE up to December 31, 2025 and 2026 respectively.

Pursuant to the EIT law, a 10% withholding tax is levied on dividends paid by PRC companies to their foreign investors. A lower withholding tax rate of 5% is applicable under the China-HK Tax Arrangement if direct foreign investors with at least 25% equity interest in the PRC companies are Hong Kong tax residents, and meet the conditions or requirements pursuant to the relevant PRC tax regulations regarding beneficial ownership. For the years ended December 31, 2024 and 2023, since the equity holder of the equity investment in SHPL was a Hong Kong incorporated company and Hong Kong tax resident that met the aforesaid requirements, the Company has used 5% to provide for deferred tax liabilities on retained earnings which were anticipated to be distributed. For the year ended December 31, 2025, following the divestment of 45% equity interest in SHPL (Note 22), the equity holder of the equity investment in SHPL no longer met the aforesaid requirements for the 5% withholding tax rate. Therefore, from the date of completion of the divestment, the deferred tax liabilities on the anticipated dividend distribution from retained earnings of SHPL was provided at 10% withholding tax rate. As at December 31, 2025, 2024 and 2023, the amounts accrued in deferred tax liabilities relating to withholding tax on dividends were determined on the basis of the distributable reserves of SHPL which will be distributed as dividends under related regulations.

Pursuant to PRC Bulletin on Issues of Enterprise Income Tax and Indirect Transfers of Assets by Non-PRC Resident Enterprises, an indirect transfer of a PRC resident enterprise by a non-PRC resident enterprise, via the transfer of an offshore intermediate holding company, shall be subject to PRC withholding tax under certain conditions.

(b) Income
 tax expense in the PRC for the year ended December 31, 2025 mainly includes US$61.1 million
 comprising US$59.5 million arising from the divestment of 45% equity interest in SHPL (Note
 22) calculated at 10% of the excess of the divestment proceeds over the cost of acquiring
 the equity investment in SHPL and additional US$1.6 million withholding tax accrued on declared
 dividends of SHPL up to the closing date of the said divestment as explained in note (a).

(c) The
 Company's subsidiary in the US with operations primarily in New Jersey is subject to
 US taxes, primarily federal and state taxes, which have been provided for at approximately
 21% (federal) and 0% to 11.5% (state tax) on the estimated assessable profits over the reporting
 years. Certain income receivable by the Company is subject to US withholding tax of 30%.
 Certain of the Group's subsidiaries are subject to corporate tax in the UK and EU countries
 at 25% and 19% to 25%, respectively, on the estimated assessable profits in relation to their
 presence in these countries.

(d) The
 Company, its certain subsidiaries incorporated in the British Virgin Islands and Cayman Islands,
 and its Hong Kong subsidiaries are subject to Hong Kong profits tax where the standard Hong
 Kong profits tax rate is 16.5%. In addition, under the Hong Kong two-tiered profits tax rates
 regime, the first HK$2.0 million (US$0.3 million) of assessable profit of a qualifying corporation
 within the Group will be taxed at 8.25%, with the remaining assessable profits taxed at 16.5%.
 Hong Kong profits tax has been provided for at the relevant rates on the estimated assessable
 profits less estimated available tax losses, if any, of these entities as applicable.

61 / 69

After the prospective adoption of ASU 2023-09 for the year ended December 31, 2025, the reconciliation of the Group's reported income tax expense to the theoretical tax amount that would arise using the statutory tax rate of the Company against the Group's income before income taxes and equity in earnings of equity investees is as follows. The statutory tax rate of HK is applied given that the Company satisfies the criteria for HK tax residency.

---

| | | |
|:---|:---|:---|
|  | **Year Ended December 31, 2025** | **Year Ended December 31, 2025** |
|  | **(in US$'000)** | **(in US$'000)** |
| Income before income taxes and equity in earnings of equity investees |  |  |
| &nbsp;&nbsp;&nbsp;PRC | 471147 |  |
| &nbsp;&nbsp;&nbsp;US and others | 93 |  |
| &nbsp;&nbsp;&nbsp;HK | 27451 |  |
| Income before income taxes and equity in earnings of equity investees | 498691 |  |
| Tax calculated at the statutory tax rate of the Company | 82284 | 16.5% |
| Tax effects of: |  |  |
| &nbsp;&nbsp;&nbsp;Different tax jurisdictions |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;PRC |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Different tax rate applicable to gain from divestment of an equity investee | (30998) | -6.2% |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Withholding tax on dividends and earnings from an equity investee | 2885 | 0.6% |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Changes in valuation allowances | 12628 | 2.5% |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Preferential tax deduction | (14835) | -3.0% |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Preferential tax rate difference | (2090) | -0.4% |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Expenses related to divestment of an equity investee | 11760 | 2.3% |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Exchange difference | 2836 | 0.6% |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Other items | 3331 | 0.6% |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;US and other tax jurisdictions | 336 | 0.1% |
| &nbsp;&nbsp;&nbsp;Nontaxable interest income | (6607) | -1.3% |
| &nbsp;&nbsp;&nbsp;Changes in valuation allowance | 1974 | 0.4% |
| &nbsp;&nbsp;&nbsp;Others | 106 | 0.1% |
| Income tax expense | 63610 | 12.8% |

---

The reconciliation of the Group's reported income tax expense to the theoretical tax amount that would arise using the tax rates of the Company against the Group's (loss)/income before income taxes and equity in earnings of equity investees is as follows:

---

| | | |
|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** |
| (Loss)/income before income taxes and equity in earnings of equity investees | (1107) | 58308 |
| Tax calculated at the statutory tax rate of the Company | (183) | 9621 |
| Tax effects of: |  |  |
| &nbsp;&nbsp;&nbsp;Different tax rates applicable in different jurisdictions | (2400) | 541 |
| &nbsp;&nbsp;&nbsp;Tax valuation allowance | 24254 | 26629 |
| &nbsp;&nbsp;&nbsp;Preferential tax rate difference | (18) | (3065) |
| &nbsp;&nbsp;&nbsp;Preferential tax deduction and credits | (22608) | (32667) |
| &nbsp;&nbsp;&nbsp;Expenses not deductible for tax purposes | 10129 | 7086 |
| &nbsp;&nbsp;&nbsp;Withholding tax on undistributed earnings of a PRC entity | 2323 | 2386 |
| &nbsp;&nbsp;&nbsp;Income not subject to tax | (5719) | (5826) |
| &nbsp;&nbsp;&nbsp;Temporary difference | 998 | (817) |
| &nbsp;&nbsp;&nbsp;Others | 416 | 621 |
| Income tax expense | 7192 | 4509 |

---

62 / 69

**(ii)** **Deferred tax assets and liabilities** 

The significant components of deferred tax assets and liabilities are as follows:

---

| | | |
|:---|:---|:---|
|  | **December 31,** | **December 31,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| Deferred tax assets |  |  |
| &nbsp;&nbsp;&nbsp;Cumulative tax losses | 318320 | 297775 |
| &nbsp;&nbsp;&nbsp;Others | 16465 | 14011 |
| Total deferred tax assets | 334785 | 311786 |
| Less: Valuation allowance | (322130) | (299338) |
|  | 12655 | 12448 |
| Deferred tax liabilities |  |  |
| &nbsp;&nbsp;&nbsp;Undistributed earnings from a PRC entity | 255 | 2990 |

---

The movements in deferred tax assets and liabilities are as follows:

---

| | | | |
|:---|:---|:---|:---|
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| As at January 1 | 9458 | 13972 | 12656 |
| Movement of previously recognized withholding tax on undistributed earnings | 2781 | 740 | 3674 |
| (Charged)/Credited to the consolidated statements of operations |  |  |  |
| &nbsp;&nbsp;&nbsp;Withholding tax on undistributed earnings of a PRC entity | (51) | (2323) | (2385) |
| &nbsp;&nbsp;&nbsp;Deferred tax on amortization of intangible assets |  | 6 | 18 |
| &nbsp;&nbsp;&nbsp;Deferred tax on temporary differences, tax loss carried forward and research tax credits | 169 | (2991) | 142 |
| Reclassification from current tax |  |  | 11 |
| Divestment of subsidiaries |  |  | (49) |
| Exchange differences | 43 | 54 | (95) |
| As at December 31 | 12400 | 9458 | 13972 |

---

The deferred tax assets and liabilities are offset when the deferred income taxes relate to the same fiscal authority.

The cumulative tax losses can be carried forward against future taxable income and will expire in the following years:

---

| | | |
|:---|:---|:---|
|  | **December 31,** | **December 31,** |
|  | **2025** | **2024** |
|  | **(in US$'000)** | **(in US$'000)** |
| No expiry date | 119736 | 94876 |
| 2025 |  | 34066 |
| 2026 | 47598 | 45465 |
| 2027 | 61117 | 58373 |
| 2028 | 105421 | 100681 |
| 2029 | 174283 | 166441 |
| 2030 | 243783 | 230851 |
| 2031 | 386281 | 368881 |
| 2032 | 605216 | 577954 |
| 2033 | 171510 | 163785 |
| 2034 | 130325 | 124299 |
| 2035 | 49972 |  |
|  | 2095242 | 1965672 |

---

The Company believes that it is more likely than not that future operations outside the US will not generate sufficient taxable income to realize the benefit of the deferred tax assets. Certain of the Company's subsidiaries have had sustained tax losses, which will expire within five years if not utilized in the case of PRC subsidiaries (ten years for HNTEs), and which will not be utilized in the case of Hong Kong, BVI and Cayman Islands subsidiaries as they do not generate taxable profits. Accordingly, a valuation allowance has been recorded against the relevant deferred tax assets arising from the tax losses.

A US subsidiary of the Company has approximately US$5.0 million and US$1.3 million US Federal and New Jersey state research tax credits which will expire between 2041 and 2044 (Federal) and 2028 and 2031 (New Jersey) respectively, if not utilized.

The table below summarizes changes in the deferred tax valuation allowance:

---

| | | | |
|:---|:---|:---|:---|
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| As at January 1 | 299338 | 283522 | 264639 |
| Charged to consolidated statements of operations | 14558 | 24254 | 26629 |
| Utilization of previously unrecognized tax losses | (3) | (2) | (39) |
| Write-off of tax losses | (5277) | (612) | (112) |
| Divestment of subsidiaries |  |  | (433) |
| Others | 119 | 20 |  |
| Exchange differences | 13395 | (7844) | (7162) |
| As at December 31 | 322130 | 299338 | 283522 |

---

As at December 31, 2025, 2024 and 2023, the Group did not have any material unrecognized uncertain tax positions.

63 / 69

**(iii)** **Income tax payable** 

---

| | | | |
|:---|:---|:---|:---|
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| As at January 1 | 1549 | 2580 | 1112 |
| Current tax | 63728 | 1884 | 2283 |
| Withholding tax upon dividend declaration from a PRC entity | 2781 | 740 | 3674 |
| Tax paid (note) | (62411) | (3587) | (3728) |
| Reclassification from prepaid tax | 631 | (41) | (397) |
| Reclassification to deferred tax |  |  | 11 |
| Reclassification to non-current liabilities | (4287) |  |  |
| Divestment of subsidiaries |  |  | (177) |
| Exchange difference | 92 | (27) | (198) |
| As at December 31 | 2083 | 1549 | 2580 |

---

Note: Income taxes paid (net of refunds) by jurisdiction for the year ended December 31, 2025 is as follows:

---

| | |
|:---|:---|
|  | **Year Ended December 31, 2025** |
|  | **(in US$'000)** |
| &nbsp;&nbsp;&nbsp;PRC | 62358 |
| &nbsp;&nbsp;&nbsp;US and others | 53 |
| &nbsp;&nbsp;&nbsp;HK |  |
| Total | 62411 |

---

**27. Earnings Per Share**

**(i)** **Basic earnings per share** 

Basic earnings per share is calculated by dividing the net income attributable to the Company by the weighted average number of outstanding ordinary shares in issue during the year. Treasury shares held by the Trustee are excluded from the weighted average number of outstanding ordinary shares in issue for purposes of calculating basic earnings per share.

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
| Weighted average number of outstanding ordinary shares in issue | 858276608 | 855351683 | 849654296 |
| Net income attributable to the Company (US$'000) | 456909 | 37729 | 100780 |
| Basic earnings per share attributable to the Company (US$ per share) | 0.53 | 0.04 | 0.12 |

---

**(ii)** **Diluted earnings per share** 

Diluted earnings per share is calculated by dividing net income attributable to the Company by the weighted average number of outstanding ordinary shares in issue and dilutive ordinary share equivalents outstanding during the year. Dilutive ordinary share equivalents include shares issuable upon the exercise or settlement of share options and LTIP awards issued by the Company using the treasury stock method.

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
| Weighted average number of outstanding ordinary shares in issue | 858276608 | 855351683 | 849654296 |
| Effect of share options and LTIP awards | 14614512 | 17477446 | 19542052 |
| Weighted average number of outstanding ordinary shares in issue and dilutive ordinary share equivalents outstanding | 872891120 | 872829129 | 869196348 |
| Net income attributable to the Company (US$'000) | 456909 | 37729 | 100780 |
| Diluted earnings per share attributable to the Company (US$ per share) | 0.52 | 0.04 | 0.12 |

---

**28. Segment Reporting**

The Group's operating segments are Oncology/Immunology and Other Ventures.

&nbsp;&nbsp;&nbsp;&nbsp;Oncology/Immunology focuses on discovering, developing, and commercializing targeted therapies and immunotherapies for the treatment of cancer and immunological diseases. Oncology/Immunology is further segregated into two core business areas:

&nbsp;&nbsp;&nbsp;&nbsp;(a) R&D:
 comprises research and development activities covering drug discovery, development, manufacturing
 and regulatory functions, out-licensing of in-house developed drugs, as well as administrative
 activities to support research and development operations; and

&nbsp;&nbsp;&nbsp;&nbsp;(b) Marketed
 Products: comprises the invoiced sales, marketing, manufacture and distribution of drugs
 developed from research and development activities including out-licensed marketed products.

Other Ventures comprises other commercial businesses which include the sales, marketing, manufacture and distribution of other prescription drugs and healthcare products.

In general, revenue, cost of revenue and operating expenses are directly attributable, or are allocated, to each segment. The Company allocates costs and expenses that are not directly attributable to a specific segment mainly on the basis of headcount or usage, depending on the nature of the relevant costs and expenses. The Company does not allocate assets to its segments as the CODM does not evaluate the performance of segments using asset information.

The performance of the reportable segments is assessed based on segment net income/(loss) attributable to the Company.

64 / 69

**(i)** **Segment information:** 

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **Year Ended December 31, 2025** | **Year Ended December 31, 2025** | **Year Ended December 31, 2025** | **Year Ended December 31, 2025** | **Year Ended December 31, 2025** | **Year Ended December 31, 2025** |
|  | **Oncology/Immunology** | **Oncology/Immunology** | **Oncology/Immunology** | | | |
|  | **R&D** | **Marketed<br> Products** | **Subtotal** | <br>**Other<br> Ventures** | <br>**Unallocated** | <br>**Total** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Revenue from external customers | 71183 | 214356 | 285539 | 262973 |  | 548512 |
| Cost of revenue |  | (82856) | (82856) | (253493) |  | (336349) |
| Research and development expenses | (148295) |  | (148295) |  |  | (148295) |
| Selling expenses |  | (32212) | (32212) | (4094) |  | (36306) |
| Administrative expenses | (34332) | (1614) | (35946) | (4754) | (26022) | (66722) |
| Gain on divestment of an equity investee |  |  |  |  | 476896 | 476896 |
| Interest income | 879 |  | 879 | 88 | 48910 | 49877 |
| Interest expense | (2035) |  | (2035) | (488) | (342) | (2865) |
| Equity in earnings of equity investees, net of tax | (1902) |  | (1902) | 24553 |  | 22651 |
| Income tax expense | (658) | (388) | (1046) | (568) | (61996) | (63610) |
| Other segment items | 4524 | (319) | 4205 | 1285 | 7630 | 13120 |
| Net (loss)/income attributable to the Company | (110636) | 96967 | (13669) | 25502 | 445076 | 456909 |
| Depreciation/ amortization | (11814) | (1312) | (13126) | (106) | (76) | (13308) |
| Additions to non-current assets (other than financial instruments and deferred tax assets) | 10331 | 20000 | 30331 | 201 | 64 | 30596 |

---

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **Year Ended December 31, 2024** | **Year Ended December 31, 2024** | **Year Ended December 31, 2024** | **Year Ended December 31, 2024** | **Year Ended December 31, 2024** | **Year Ended December 31, 2024** |
|  | **Oncology/Immunology** | **Oncology/Immunology** | **Oncology/Immunology** | | | |
|  | **R&D** | **Marketed<br> Products** | **Subtotal** | <br>**Other<br> Ventures** | <br>**Unallocated** | <br>**Total** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Revenue from external customers | 91831 | 271534 | 363365 | 266836 |  | 630201 |
| Cost of revenue |  | (92783) | (92783) | (256101) |  | (348884) |
| Research and development expenses | (212109) |  | (212109) |  |  | (212109) |
| Selling expenses |  | (44287) | (44287) | (4330) |  | (48617) |
| Administrative expenses | (36126) | (784) | (36910) | (4996) | (22390) | (64296) |
| Interest income | 818 |  | 818 | 182 | 39080 | 40080 |
| Interest expense | (1825) |  | (1825) | (653) | (394) | (2872) |
| Equity in earnings of an equity investee, net of tax |  |  |  | 46469 |  | 46469 |
| Income tax expense | (3475) | (841) | (4316) | (513) | (2363) | (7192) |
| Other segment items | 3662 | (176) | 3486 | 830 | 633 | 4949 |
| Net (loss)/income attributable to the Company | (157224) | 132663 | (24561) | 47724 | 14566 | 37729 |
| Depreciation/ amortization | (11331) | (762) | (12093) | (158) | (90) | (12341) |
| Additions to non-current assets (other than financial instruments and deferred tax assets) | 13442 |  | 13442 | 2194 | 1234 | 16870 |

---

65 / 69

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **Year Ended December 31, 2023** | **Year Ended December 31, 2023** | **Year Ended December 31, 2023** | **Year Ended December 31, 2023** | **Year Ended December 31, 2023** | **Year Ended December 31, 2023** |
|  | **Oncology/Immunology** | **Oncology/Immunology** | **Oncology/Immunology** | | | |
|  | **R&D** | **Marketed<br> Products** | **Subtotal** | <br>**Other<br> Ventures** | <br>**Unallocated** | <br>**Total** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Revenue from external customers | 364451 | 164165 | 528616 | 309383 |  | 837999 |
| Cost of revenue |  | (91726) | (91726) | (292721) |  | (384447) |
| Research and development expenses | (302001) |  | (302001) |  |  | (302001) |
| Selling expenses |  | (45505) | (45505) | (7887) |  | (53392) |
| Administrative expenses | (46134) | (1832) | (47966) | (5435) | (26383) | (79784) |
| Interest income | 802 |  | 802 | 455 | 34888 | 36145 |
| Interest expense | (279) |  | (279) | (38) | (442) | (759) |
| Equity in earnings of an equity investee, net of tax |  |  |  | 47295 |  | 47295 |
| Income tax expense | (628) | (159) | (787) | (1201) | (2521) | (4509) |
| Other segment items | 9293 | 715 | 10008 | 421 | (6196) | 4233 |
| Net income/(loss) attributable to the Company | 25504 | 25658 | 51162 | 50272 | (654) | 100780 |
| Depreciation/ amortization | (7640) |  | (7640) | (344) | (223) | (8207) |
| Additions to non-current assets (other than financial instruments and deferred tax assets) | 41338 |  | 41338 | 330 | 86 | 41754 |

---

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **December 31, 2025** | **December 31, 2025** | **December 31, 2025** | **December 31, 2025** | **December 31, 2025** | **December 31, 2025** |
|  | **Oncology/Immunology** | **Oncology/Immunology** | **Oncology/Immunology** | | | |
|  | **R&D** | **Marketed<br> Products** | **Subtotal** | <br>**Other<br> Ventures** | <br>**Unallocated** | <br>**Total** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Total assets | 175378 | 91353 | 266731 | 117359 | 1369007 | 1753097 |
| Property, plant and equipment | 94194 |  | 94194 | 370 | 59 | 94623 |
| Right-of-use assets | 1451 |  | 1451 | 918 | 658 | 3027 |
| Leasehold land | 10954 |  | 10954 |  |  | 10954 |
| Intangible asset (note) |  | 8941 | 8941 |  |  | 8941 |
| Goodwill |  |  |  | 3112 |  | 3112 |
| Investment in equity investees | 5725 |  | 5725 | 5140 |  | 10865 |

---

Note: During the year ended December 31, 2025, tazemetostat was granted approval by the National Medical Products Administration of China for the treatment of adult patients with relapsed or refractory follicular lymphoma with EZH2 mutation, triggering a US$10 million milestone payment, and a corresponding intangible asset was recognized.

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **December 31, 2024** | **December 31, 2024** | **December 31, 2024** | **December 31, 2024** | **December 31, 2024** | **December 31, 2024** |
|  | **Oncology/Immunology** | **Oncology/Immunology** | **Oncology/Immunology** | | | |
|  | **R&D** | **Marketed<br> Products** | **Subtotal** | <br>**Other<br> Ventures** | <br>**Unallocated** | <br>**Total** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Total assets | 225661 | 88502 | 314163 | 194604 | 765429 | 1274196 |
| Property, plant and equipment | 91929 |  | 91929 | 448 | 121 | 92498 |
| Right-of-use assets | 1845 |  | 1845 | 1615 | 1037 | 4497 |
| Leasehold land | 10706 |  | 10706 |  |  | 10706 |
| Goodwill |  |  |  | 2990 |  | 2990 |
| Investment in an equity investee |  |  |  | 77765 |  | 77765 |
| Investment in equity security | 5000 |  | 5000 |  |  | 5000 |

---

66 / 69

Unallocated mainly represent corporate expenses which include corporate administrative costs, corporate employee benefit expenses and the relevant share-based compensation expenses, net of interest income, as well as other one-off items. Unallocated assets mainly comprise cash and cash equivalents and short-term investments.

**(ii)** **Geographic information:** 

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Revenue from external customers: |  |  |  |
| &nbsp;&nbsp;&nbsp;PRC | 407454 | 452413 | 484895 |
| &nbsp;&nbsp;&nbsp;US and Others | 141058 | 177788 | 353104 |
|  | 548512 | 630201 | 837999 |

---

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **December 31,** | **December 31,** | **December 31,** | **December 31,** | **December 31,** | **December 31,** |
|  | **2025** | **2025** | **2025** | **2024** | **2024** | **2024** |
|  | **PRC** | **US and <br> Others** | **Total** | **PRC** | **US and <br> Others** | **Total** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Total assets | 1705638 | 47459 | 1753097 | 1212722 | 61474 | 1274196 |
| Property, plant and equipment | 94183 | 440 | 94623 | 91849 | 649 | 92498 |
| Right-of-use assets | 2489 | 538 | 3027 | 4086 | 411 | 4497 |
| Leasehold land | 10954 |  | 10954 | 10706 |  | 10706 |
| Other intangible asset | 8941 |  | 8941 |  |  |  |
| Goodwill | 3112 |  | 3112 | 2990 |  | 2990 |
| Investment in equity investees | 5140 | 5725 | 10865 | 77765 |  | 77765 |
| Investment in equity security |  |  |  | 5000 |  | 5000 |

---

**(iii)** **Other information:** 

A summary of customers which accounted for over 10% of the Group's revenue for the years ended December 31, 2025, 2024 and 2023 is as follows:

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Customer A | 141058 | 177789 | 353104 |
| Customer B | 75759 | 85361 | 84065 |

---

Customer A and B are included in Oncology/Immunology.

67 / 69

**29. Note to Consolidated Statements of Cash Flows**

Reconciliation of net income for the year to net cash (used in)/generated from operating activities:

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Net income | 457732 | 38170 | 101094 |
| Adjustments to reconcile net income to net cash (used in)/generated from operating activities |  |  |  |
| &nbsp;&nbsp;&nbsp;Depreciation and amortization | 13308 | 12341 | 8207 |
| &nbsp;&nbsp;&nbsp;(Gain)/loss on disposals of property, plant and equipment | (21) | 10 | 86 |
| &nbsp;&nbsp;&nbsp;Impairment of property, plant and equipment | 89 | 2915 | 3678 |
| &nbsp;&nbsp;&nbsp;Provision for excess and obsolete inventories, net | (213) | 645 | 552 |
| &nbsp;&nbsp;&nbsp;Provision for credit losses, net | (75) | (98) | 125 |
| &nbsp;&nbsp;&nbsp;Share-based compensation expense — share options | 2513 | 3069 | 6184 |
| &nbsp;&nbsp;&nbsp;Share-based compensation expense — LTIP | 12779 | 18540 | 30416 |
| &nbsp;&nbsp;&nbsp;Equity in earnings of equity investees, net of tax | (22651) | (46469) | (47295) |
| &nbsp;&nbsp;&nbsp;Gain from divestment of equity investees | (476896) |  | (45) |
| &nbsp;&nbsp;&nbsp;Dividends received from SHPL | 6987 | 34936 | 42308 |
| &nbsp;&nbsp;&nbsp;Gain on investment in ImageneBio | (2037) |  |  |
| &nbsp;&nbsp;&nbsp;Out-licensing income from Inmagene |  | (5000) |  |
| &nbsp;&nbsp;&nbsp;Changes in income tax balances | 1199 | 3605 | 780 |
| &nbsp;&nbsp;&nbsp;Changes in right-of-use assets | 1572 | 51 | 3692 |
| &nbsp;&nbsp;&nbsp;Gain from divestment of subsidiaries |  |  | (96) |
| &nbsp;&nbsp;&nbsp;Unrealized currency translation loss/(gain) | 1921 | (49) | (1574) |
| Changes in operating assets and liabilities |  |  |  |
| &nbsp;&nbsp;&nbsp;Accounts receivable | 28862 | (38545) | (21336) |
| &nbsp;&nbsp;&nbsp;Other receivables, prepayments and deposits | (4635) | (3256) | 8624 |
| &nbsp;&nbsp;&nbsp;Amounts due from related parties | (3) | 228 | (339) |
| &nbsp;&nbsp;&nbsp;Inventories | 9542 | (772) | 4135 |
| &nbsp;&nbsp;&nbsp;Accounts payable | 3012 | 6194 | (32542) |
| &nbsp;&nbsp;&nbsp;Other payables and accruals | (48551) | 2433 | (4409) |
| &nbsp;&nbsp;&nbsp;Lease liabilities | (2423) | 325 | (1752) |
| &nbsp;&nbsp;&nbsp;Deferred revenue | (49564) | (25966) | 119810 |
| &nbsp;&nbsp;&nbsp;Other non-current assets | 1540 | (1408) | 364 |
| &nbsp;&nbsp;&nbsp;Amounts due to related parties | (292) | (1452) | (1402) |
| &nbsp;&nbsp;&nbsp;Other non-current liabilities | 1648 | 50 | (7) |
| Total changes in operating assets and liabilities | (60864) | (62169) | 71146 |
| Net cash (used in)/generated from operating activities | (64657) | 497 | 219258 |

---

68 / 69

**30. Litigation**

From time to time, the Group may become involved in litigation relating to claims arising from the ordinary course of business. The Group believes that there are currently no claims or actions pending against the Group, the ultimate disposition of which could have a material adverse effect on the Group's financial position, results of operations or cash flows. However, litigation is subject to inherent uncertainties and the Group's view of these matters may change in the future. When an unfavorable outcome occurs, there exists the possibility of a material adverse impact on the Group's financial position, results of operations or cash flows for the periods in which the unfavorable outcome occurs, and potentially in future periods.

On May 17, 2019, Luye Pharma Hong Kong Ltd. ("Luye") issued a notice to the Group purporting to terminate a distribution agreement that granted the Group exclusive commercial rights to Seroquel in the PRC for failure to meet a pre-specified target. The Group disagrees with this assertion and believes that Luye have no basis for termination. As a result, the Group commenced legal proceedings in 2019 in order to seek damages. On October 21, 2021 (and a decision on costs and interest in December 2021), the Group was awarded an amount of US$36.0 million (RMB253.2 million) with interest of 5.5% per annum from the date of the award until payment and recovery of costs of approximately US$2.2 million (collectively the "Award"). On June 27, 2022, Luye provided the Group a bank guarantee of up to RMB286.0 million (updated to RMB335.2 million on February 28, 2026) to cover the Award amounts, pending the outcome of an application by Luye to the High Court of Hong Kong to set aside the Award and subsequent appeals. On July 26, 2022, Luye's application to set aside the Award was dismissed by the High Court with costs awarded in favor of the Group. On October 7, 2022, Luye filed a Notice of Appeal to the Court of Appeal regarding the dismissal and the notice was accepted on November 8, 2022. On June 6, 2023, an appeal hearing filed by Luye was heard by the Court of Appeal and judgment is awaited. The legal proceedings are ongoing and as no Award amounts have been received as at the issuance date of these consolidated financial statements, no Award amounts have been recognized and no adjustment has been made to Seroquel-related balances as at December 31, 2025. Such Seroquel-related balances include accounts receivable, accounts payable and other payables of US$1.1 million, US$0.9 million and US$1.2 million respectively.

**31. Restricted Net Assets**

Relevant PRC laws and regulations permit payments of dividends by the Company's subsidiaries in the PRC only out of their retained earnings, if any, as determined in accordance with PRC accounting standards and regulations. In addition, the Company's subsidiaries in the PRC are required to make certain appropriations of net after-tax profits or increases in net assets to the statutory surplus fund prior to payment of any dividends. In addition, registered share capital and capital reserve accounts are restricted from withdrawal in the PRC, up to the amount of net assets held in each subsidiary. As a result of these and other restrictions under PRC laws and regulations, the Company's subsidiaries in the PRC are restricted in their ability to transfer their net assets to the Group in terms of cash dividends, loans or advances, with restricted portions amounting to US$2.0 million and US$1.6 million as at December 31, 2025 and 2024 respectively, which excludes the Company's subsidiaries with a shareholders' deficit. Even though the Group currently does not require any such dividends, loans or advances from the PRC subsidiaries, for working capital and other funding purposes, the Group may in the future require additional cash resources from the Company's subsidiaries in the PRC due to changes in business conditions, to fund future acquisitions and development, or merely to declare and pay dividends to make distributions to shareholders.

In addition, the Group has an equity investee in the PRC, where the Group's equity in undistributed earnings amounted to US$2.6 million and US$59.8 million as at December 31, 2025 and 2024 respectively.

**32. Subsequent Events**

The Group evaluated subsequent events through March 5, 2026, which is the date when the consolidated financial statements were issued.

69 / 69

## Exhibit 99.2

**Exhibit 99.2**

**Additional Information: Company Balance Sheets (Parent Company Only)**

---

| | | | |
|:---|:---|:---|:---|
|  | | **December 31,** | **December 31,** |
|  |<br>**Note** | **2025** | **2024** |
|  | | **(in US$'000)** | **(in US$'000)** |
| **Assets** |  |  |  |
| Current assets |  |  |  |
| &nbsp;&nbsp;&nbsp;Cash and cash equivalents |  | 99 | 98 |
| &nbsp;&nbsp;&nbsp;Other receivables, prepayments and deposits |  | 552 | 961 |
| **Total current assets** |  | **651** | **1059** |
| Investments in subsidiaries |  | 1286965 | 817364 |
| **Total assets** |  | **1287616** | **818423** |
| **Liabilities and shareholders' equity** |  |  |  |
| Current liabilities |  |  |  |
| &nbsp;&nbsp;&nbsp;Other payables and accruals |  | 49540 | 58116 |
| &nbsp;&nbsp;&nbsp;Income tax payable |  |  | 48 |
| **Total current liabilities** |  | **49540** | **58164** |
| Other non-current liabilities |  | 150 | 330 |
| **Total liabilities** |  | **49690** | **58494** |
| Commitments and contingencies | 17 |  |  |
| **Company's shareholders' equity** |  |  |  |
| &nbsp;&nbsp;&nbsp;Ordinary shares; $0.10 par value; 1,500,000,000 shares authorized; 872,327,620 and 871,601,095 shares issued at December 31, 2025 and 2024 respectively | 18 | 87233 | 87160 |
| &nbsp;&nbsp;&nbsp;Additional paid-in capital |  | 1533868 | 1517526 |
| &nbsp;&nbsp;&nbsp;Accumulated losses |  | (378643) | (833172) |
| &nbsp;&nbsp;&nbsp;Accumulated other comprehensive loss |  | (4532) | (11585) |
| **Total Company's shareholders' equity** |  | **1237926** | **759929** |
| **Total liabilities and shareholders' equity** |  | **1287616** | **818423** |

---

**Dividends**

No dividend has been declared or paid by the Company since its incorporation.

Page **1** of **7**

**Directors' Remuneration**

Directors' remuneration disclosed pursuant to the Listing Rules, Section 383(1)(a), (b), (c) and (f) of the Hong Kong Companies Ordinance and Part 2 of the Companies (Disclosure of Information about Benefits of Directors) Regulation, is as follows:

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Fees: | 845 | 675 | 615 |
| Other remuneration |  |  |  |
| &nbsp;&nbsp;&nbsp;Salaries, allowances and benefits in kind | 1241 | 1200 | 1154 |
| &nbsp;&nbsp;&nbsp;Pension contributions | 109 | 105 | 101 |
| &nbsp;&nbsp;&nbsp;Performance related bonuses | 1411 | 1795 | 2008 |
| &nbsp;&nbsp;&nbsp;Share-based compensation expenses (note) | 4006 | 3279 | 2573 |
|  | 6767 | 6379 | 5836 |
|  | 7612 | 7054 | 6451 |

---

Note: During the years ended December 31, 2025, 2024 and 2023, certain directors were granted share options and LTIP awards in respect of their services to the Group under the share option schemes and LTIP of the Company, further details of which are set out in Note 19. The share-based compensation expenses were recognized in the consolidated statements of operations during the years ended December 31, 2025, 2024 and 2023.

**(i)** **Independent non-executive directors** 

The fees paid to independent non-executive directors were as follows:

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Mok Shu Kam, Tony | 113 | 116 | 115 |
| Renu Bhatia (note (a)) | 105 | 59 |  |
| Chaohong Hu (note (b)) | 99 | 9 |  |
| Wong Tak Wai (note (c)) | 83 |  |  |
| Paul Rutherford Carter (note (d)) | 77 | 117 | 117 |
| Graeme Allan Jack (note (e)) | 70 | 111 | 111 |
| Tan Shao Weng, Daniel (note (f)) | 18 |  |  |
| Karen Jean Ferrante (note (g)) |  |  | 37 |
|  | 565 | 412 | 380 |

---

The share-based compensation expenses of the independent non-executive directors were as follows:

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Mok Shu Kam, Tony | 13 | 32 | 71 |
| Paul Rutherford Carter (note (d)) | (50) | 32 | 71 |
| Graeme Allan Jack (note (e)) | (50) | 32 | 71 |
| Karen Jean Ferrante (note (g)) |  |  | (101) |
|  | (87) | 96 | 112 |

---

Notes:

(a) Appointed as an independent non-executive
 director on May 13, 2024.

(b) Appointed as an independent non-executive
 director on November 21, 2024.

(c) Appointed as an independent non-executive
 director on March 6, 2025.

(d) Retired
 as an independent non-executive director on May 13, 2025. The amount also included $34,000
 of other cash benefits paid to the director.

(e) Retired as an independent non-executive director
 on May 13, 2025. The amount also included $30,000 of other cash benefits paid to the
 director.

(f) Appointed as an independent non-executive
 director on October 15, 2025.

(g) Retired as an independent non-executive director
 on May 12, 2023.

Page **2** of **7**

There were no other remunerations payable to independent non-executive directors during the years ended December 31, 2025, 2024 and 2023.

**(ii)** **Executive directors and non-executive directors** 

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **Year Ended December 31, 2025** | **Year Ended December 31, 2025** | **Year Ended December 31, 2025** | **Year Ended December 31, 2025** | **Year Ended December 31, 2025** | **Year Ended December 31, 2025** |
|  | **Fees** | **Salaries,<br> allowances <br> and benefits<br> in kind** | **Pension<br> contributions** | **Performance<br> related<br> bonuses** | **Share-based<br> compensation** | **Total** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Executive directors |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Weiguo Su | 75 | 850 | 75 | 752 | 3668 | 5420 |
| &nbsp;&nbsp;&nbsp;Cheng Chig Fung, Johnny | 75 | 391 | 34 | 659 | 399 | 1558 |
|  | 150 | 1241 | 109 | 1411 | 4067 | 6978 |
| Non-executive directors |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Dan Eldar | 130 |  |  |  | 13 | 143 |
| &nbsp;&nbsp;&nbsp;Edith Shih |  |  |  |  | 13 | 13 |
|  | 130 |  |  |  | 26 | 156 |
|  | 280 | 1241 | 109 | 1411 | 4093 | 7134 |

---

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **Year Ended December 31, 2024** | **Year Ended December 31, 2024** | **Year Ended December 31, 2024** | **Year Ended December 31, 2024** | **Year Ended December 31, 2024** | **Year Ended December 31, 2024** |
|  | **Fees** | **Salaries,<br> allowances<br> and benefits<br> in kind** | **Pension<br> contributions** | **Performance<br> related<br> bonuses** | **Share-based<br> compensation** | **Total** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Executive directors |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;To Chi Keung, Simon (note (a)) | 32 |  |  |  | (80) | (48) |
| &nbsp;&nbsp;&nbsp;Weiguo Su | 75 | 820 | 72 | 1282 | 2746 | 4995 |
| &nbsp;&nbsp;&nbsp;Cheng Chig Fung, Johnny | 75 | 380 | 33 | 513 | 453 | 1454 |
|  | 182 | 1200 | 105 | 1795 | 3119 | 6401 |
| Non-executive directors |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Dan Eldar | 81 |  |  |  | 32 | 113 |
| &nbsp;&nbsp;&nbsp;Edith Shih |  |  |  |  | 32 | 32 |
|  | 81 |  |  |  | 64 | 145 |
|  | 263 | 1200 | 105 | 1795 | 3183 | 6546 |

---

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **Year Ended December 31, 2023** | **Year Ended December 31, 2023** | **Year Ended December 31, 2023** | **Year Ended December 31, 2023** | **Year Ended December 31, 2023** | **Year Ended December 31, 2023** |
|  | **Fees** | **Salaries,<br> allowances<br> and benefits<br> in kind** | **Pension<br> contributions** | **Performance<br> related<br> bonuses** | **Share-based<br> compensation** | **Total** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Executive directors |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;To Chi Keung, Simon | 85 |  |  |  | 71 | 156 |
| &nbsp;&nbsp;&nbsp;Weiguo Su (note (b)) | 75 | 805 | 71 | 1500 | 1659 | 4110 |
| &nbsp;&nbsp;&nbsp;Cheng Chig Fung, Johnny | 75 | 349 | 30 | 508 | 589 | 1551 |
|  | 235 | 1154 | 101 | 2008 | 2319 | 5817 |
| Non-executive directors |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Dan Eldar |  |  |  |  | 71 | 71 |
| &nbsp;&nbsp;&nbsp;Edith Shih |  |  |  |  | 71 | 71 |
|  |  |  |  |  | 142 | 142 |
|  | 235 | 1154 | 101 | 2008 | 2461 | 5959 |

---

Notes:

(a) Retired
 as an executive director on May 17, 2024.

(b) In
 connection with share options granted in the year ended December 31, 2016 under the
 2015 Share Option Scheme, Dr. Weiguo Su was awarded retention bonuses payable when and
 if he exercised his options. During the year ended December 31, 2023, a retention bonus
 of US$5,225,000 was settled when he exercised such options, which amount is not included
 in the table above.

Page **3** of **7**

**Five Highest-Paid Employees**

The five highest-paid employees during the years ended December 31, 2025, 2024 and 2023 included the following number of directors and non-directors:

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2025** | **2024** | **2024** | **2023** | **2023** |
| Directors |  | 2 |  | 2 |  | 2 |
| Non-directors | | 3 | | 3 | | 3 |
|  | | 5 | | 5 | | 5 |

---

Details of the remuneration for the years ended December 31, 2025, 2024 and 2023 of the five highest-paid employees who are non-directors (the "Non-director Individuals") were as follows:

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Salaries, allowances and benefits in kind | 1327 | 1172 | 1506 |
| Pension contributions | 37 | 9 | 54 |
| Performance related bonuses | 1365 | 1577 | 1909 |
| Share-based compensation expenses (note) | 728 | 2008 | 3226 |
|  | 3457 | 4766 | 6695 |

---

Note: During the years ended December 31, 2025, 2024 and 2023, the non-director Individuals were granted share options and LTIP awards in respect of their services to the Group under the share option schemes and LTIP of the Company, further details of which are set out in Note 19. The share-based compensation expenses were recognized in the consolidated statements of operations during the years ended December 31, 2025, 2024 and 2023.

The number of non-director Individuals whose remuneration fell within the following bands is as follows:

---

| | | | |
|:---|:---|:---|:---|
|  | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2025** | **2024** | **2023** |
| HK$7,500,000 to HK$8,000,000 | 1 |  |  |
| HK$8,500,000 to HK$9,000,000 | 1 | 1 |  |
| HK$9,000,000 to HK$9,500,000 |  | 1 |  |
| HK$10,000,000 to HK$10,500,000 | 1 |  |  |
| HK$12,000,000 to HK$12,500,000 |  |  | 1 |
| HK$15,500,000 to HK$16,000,000 |  |  | 1 |
| HK$19,000,000 to HK$19,500,000 |  | 1 |  |
| HK$24,000,000 to HK$24,500,000 |  |  | 1 |
|  | 3 | 3 | 3 |

---

During the years ended December 31, 2025, 2024 and 2023, no remuneration was paid by the Group to any directors or non-director Individuals as an inducement to join the Group or as compensation for loss of office. Additionally, none of the directors or non-director Individuals have waived any remuneration during the years ended December 31, 2025, 2024 and 2023.

Page **4** of **7**

**Reconciliation between US GAAP and International Financial Reporting Standards**

These consolidated financial statements are prepared in accordance with US GAAP, which differ in certain respects from International Financial Reporting Standards ("IFRS"). The effects of material differences prepared under US GAAP and IFRS are as follows:

**(i) Reconciliation of consolidated statements of operations**

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
|  | **Year Ended December 31, 2025** | **Year Ended December 31, 2025** | **Year Ended December 31, 2025** | **Year Ended December 31, 2025** | **Year Ended December 31, 2025** |
|  | | **IFRS adjustments** | **IFRS adjustments** | **IFRS adjustments** | |
|  |<br>**Amounts as<br> reported <br> under <br> US GAAP** | **Lease<br> amortization<br> (note (a))** | **Tax effects of<br> intercompany<br> unrealized<br> profit<br> (note (b))** | **Capitalization<br> of rights<br> (note (c))** |<br>**Amounts<br> under<br> IFRS** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Cost of goods — third parties | (291360) | 9 |  |  | (291351) |
| Research and development expenses | (148295) | 46 |  | (16109) | (164358) |
| Selling expenses | (36306) | 22 |  |  | (36284) |
| Administrative expenses | (66722) | 51 |  |  | (66671) |
| **Total operating expenses** | **(587672)** | **128** | **—** | **(16109)** | **(603653)** |
| Gain on divestment of an equity investee | 476896 | 18 | (151) |  | 476763 |
| Interest expense | (2865) | (193) |  |  | (3058) |
| Other expense | (5767) | 33 |  |  | (5734) |
| **Total other income/(expense)** | **60955** | **(160)** | **—** | **—** | **60795** |
| **Income/(loss) before income taxes and equity in earnings of equity investees** | **498691** | **(14)** | **(151)** | **(16109)** | **482417** |
| Equity in earnings of equity investees, net of tax | 22651 | 7 | (75) |  | 22583 |
| **Net income** | **457732** | **(7)** | **(226)** | **(16109)** | **441390** |
| Less: Net income attributable to non-controlling interests | (823) | 3 |  | 25 | (795) |
| **Net income attributable to the Company** | **456909** | **(4)** | **(226)** | **(16084)** | **440595** |

---

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **Year Ended December 31, 2024** | **Year Ended December 31, 2024** | **Year Ended December 31, 2024** | **Year Ended December 31, 2024** |
|  | | **IFRS adjustments** | **IFRS adjustments** | |
|  |<br>**Amounts as<br> reported <br> under <br> US GAAP** | **Lease<br> amortization<br> (note (a))** | **Tax effects of<br> intercompany<br> unrealized<br> profit<br> (note (b))** |<br>**Amounts<br> under<br> IFRS** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Cost of goods — third parties | (294918) | 59 |  | (294859) |
| Research and development expenses | (212109) | 96 |  | (212013) |
| Selling expenses | (48617) | 29 |  | (48588) |
| Administrative expenses | (64296) | 82 |  | (64214) |
| **Total operating expenses** | **(673906)** | **266** | **—** | **(673640)** |
| Interest expense | (2872) | (219) |  | (3091) |
| Other expense | (4884) | 36 |  | (4848) |
| **Total other income/(expense)** | **42598** | **(183)** | **—** | **42415** |
| **Income/(loss) before income taxes and equity in earnings of equity investees** | **(1107)** | **83** | **—** | **(1024)** |
| Equity in earnings of equity investees, net of tax | 46469 | 14 | (57) | 46426 |
| **Net income** | **38170** | **97** | **(57)** | **38210** |
| Less: Net income attributable to non-controlling interests | (441) | (2) |  | (443) |
| **Net income attributable to the Company** | **37729** | **95** | **(57)** | **37767** |

---

Page **5** of **7**

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **Year Ended December 31, 2023** | **Year Ended December 31, 2023** | **Year Ended December 31, 2023** | **Year Ended December 31, 2023** |
|  | | **IFRS adjustments** | **IFRS adjustments** | |
|  |<br>**Amounts as<br> reported <br> under <br> US GAAP** | **Lease<br> amortization<br> (note (a))** | **Tax effects of<br> intercompany<br> unrealized<br> profit<br> (note (b))** |<br>**Amounts<br> under<br> IFRS** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Cost of goods — third parties | (331984) | 66 |  | (331918) |
| Research and development expenses | (302001) | 106 |  | (301895) |
| Selling expenses | (53392) | 46 |  | (53346) |
| Administrative expenses | (79784) | 89 |  | (79695) |
| **Total operating expenses** | **(819624)** | **307** | **—** | **(819317)** |
| Interest expense | (759) | (281) |  | (1040) |
| Other expense | (8402) | 63 |  | (8339) |
| **Total other income/(expense)** | **39933** | **(218)** | **—** | **39715** |
| **Income/(loss) before income taxes and equity in earnings of equity investees** | **58308** | **89** | **—** | **58397** |
| Equity in earnings of equity investees, net of tax | 47295 | (1) | 307 | 47601 |
| **Net income** | **101094** | **88** | **307** | **101489** |
| Less: Net income attributable to non-controlling interests | (314) | (19) |  | (333) |
| **Net income attributable to the Company** | **100780** | **69** | **307** | **101156** |

---

**(ii) Reconciliation of consolidated balance sheets**

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
|  | **December 31, 2025** | **December 31, 2025** | **December 31, 2025** | **December 31, 2025** | **December 31, 2025** | **December 31, 2025** | **December 31, 2025** |
|  | | **IFRS adjustments** | **IFRS adjustments** | **IFRS adjustments** | **IFRS adjustments** | **IFRS adjustments** | |
|  |<br>**Amounts as<br> reported <br> under<br> US GAAP** | **Lease<br> amortization<br> (note (a))** | **Tax effects of<br> intercompany<br> unrealized<br> profit<br> (note (b))** | **Capitalization <br> of rights<br> (note (c))** | **Issuance<br> costs<br> (note (d))** | **LTIP<br> classification<br> (note (e))** |<br>**Amounts<br> under<br> IFRS** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Right-of-use assets | 3027 | (86) |  |  |  |  | 2941 |
| Investment in equity investees | 10865 | (1) | 24 |  |  |  | 10888 |
| **Total assets** | **1753097** | **(87)** | **24** |  | **—** | **—** | **1753034** |
| Other payables and accruals | 208892 |  |  |  |  | (883) | 208009 |
| **Total current liabilities** | **315775** | **—** | **—** |  | **—** | **(883)** | **314892** |
| **Total liabilities** | **501835** | **—** | **—** |  | **—** | **(883)** | **500952** |
| Additional paid-in capital | 1533868 |  |  |  | (697) | 883 | 1534054 |
| Accumulated losses | (378643) | (86) | 24 |  | 697 |  | (378008) |
| Accumulated other comprehensive loss | (4532) | 11 |  |  |  |  | (4521) |
| **Total Company's shareholders' equity** | **1237926** | **(75)** | **24** |  | **—** | **883** | **1238758** |
| Non-controlling interests | 13336 | (12) |  |  |  |  | 13324 |
| **Total shareholders' equity** | **1251262** | **(87)** | **24** |  | **—** | **883** | **1252082** |

---

Page **6** of **7**

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
|  | **December 31, 2024** | **December 31, 2024** | **December 31, 2024** | **December 31, 2024** | **December 31, 2024** | **December 31, 2024** | **December 31, 2024** |
|  | | **IFRS adjustments** | **IFRS adjustments** | **IFRS adjustments** | **IFRS adjustments** | **IFRS adjustments** | |
|  |<br>**Amounts as<br> reported <br> under<br> US GAAP** | **Lease<br> amortization<br> (note (a))** | **Tax effects of<br> intercompany<br> unrealized<br> profit<br> (note (b))** | **Capitalization<br> of rights<br> (note (c))** | **Issuance <br> costs<br> (note (d))** | **LTIP<br> classification<br> (note (e))** |<br>**Amounts<br> under<br> IFRS** |
|  | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** | **(in US$'000)** |
| Right-of-use assets | 4497 | (52) |  |  |  |  | 4445 |
| Investment in equity investees | 77765 | (22) | 246 |  |  |  | 77989 |
| Other non-current assets | 12443 |  |  | 14815 |  |  | 27258 |
| **Total assets** | **1274196** | **(74)** | **246** | **14815** | **—** | **—** | **1289183** |
| Other payables and accruals | 256124 |  |  |  |  | (493) | 255631 |
| **Total current liabilities** | **376562** | **—** | **—** | **—** | **—** | **(493)** | **376069** |
| **Total liabilities** | **502343** | **—** | **—** | **—** | **—** | **(493)** | **501850** |
| Additional paid-in capital | 1517526 |  |  |  | (697) | 493 | 1517322 |
| Accumulated losses | (833172) | (82) | 250 | 16084 | 697 |  | (816223) |
| Accumulated other comprehensive loss | (11585) | 16 | (4) | (1294) |  |  | (12867) |
| **Total Company's shareholders' equity** | **759929** | **(66)** | **246** | **14790** | **—** | **493** | **775392** |
| Non-controlling interests | 11924 | (8) |  | 25 |  |  | 11941 |
| **Total shareholders' equity** | **771853** | **(74)** | **246** | **14815** | **—** | **493** | **787333** |

---

Notes:

(a) Lease amortization

Under US GAAP, for operating leases, the amortization of right-of-use assets and the interest expense element of lease liabilities are recorded together as lease expenses, which results in a straight-line recognition effect in the consolidated statements of operations.

Under IFRS, all leases are accounted for like finance leases where right-of-use assets are generally depreciated on a straight-line basis while lease liabilities are measured under the effective interest method, which results in higher expenses at the beginning of the lease term and lower expenses near the end of the lease term.

(b) Tax effects of intercompany unrealized profit

Under US GAAP, deferred taxes for unrealized profit resulting from intercompany sales of inventory is not recognized.

Under IFRS, deferred taxes for unrealized profit resulting from an intercompany sale of inventory is recognized at the buyer's tax rate.

(c) Capitalization of development and commercial
 rights

Under US GAAP, the acquired development and commercial rights do not meet the capitalization criteria as further development is needed as of the acquisition date and there is no alternative future use. Such rights are considered as IPR&D and were expensed to research and development expenses.

Under IFRS, the acquired development and commercial rights were capitalized to intangible assets. The recognition criterion is always assumed to be met as the price already reflects the probability that future economic benefits will flow to the Group. For the year ended December 31, 2025, the intangible asset was impaired after completing an impairment assessment.

(d) Issuance costs

Under US GAAP and IFRS, there are differences in the criteria for capitalization of issuance costs incurred in the offering of equity securities.

(e) LTIP classification

Under US GAAP, LTIP awards with performance conditions are classified as liability-settled awards prior to the determination date as they settle in a variable number of shares based on a determinable monetary amount, which is determined upon the actual achievement of performance targets. After the determination date, the LTIP awards are reclassified as equity-settled awards.

Under IFRS, LTIP awards are classified as equity-settled awards, both prior to and after the determination date, as they are ultimately settled in ordinary shares or the equivalent ADS of the Company instead of cash.

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