# EDGAR Filing Document

**Accession Number:** 0001482416
**File Stem:** 0001214659-26-006200
**Filing Date:** 2026-5
**Character Count:** 11401
**Document Hash:** 6bffc40afa886ba6993e432493607378
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001214659-26-006200.hdr.sgml**: 20260514

**ACCESSION NUMBER**: 0001214659-26-006200

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20260331

**FILED AS OF DATE**: 20260514

**DATE AS OF CHANGE**: 20260514

**EFFECTIVENESS DATE**: 20260514

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Sio Capital Management, LLC
- **CENTRAL INDEX KEY:** 0001482416

**ORGANIZATION NAME:**
- **EIN:** 204586565
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-13691
- **FILM NUMBER:** 26978489

**BUSINESS ADDRESS:**
- **STREET 1:** 600 THIRD AVENUE
- **STREET 2:** 2ND FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10016
- **BUSINESS PHONE:** 212-601-9792

**MAIL ADDRESS:**
- **STREET 1:** 600 THIRD AVENUE
- **STREET 2:** 2ND FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10016

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 03-31-2026

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** Sio Capital Management LLC<br>**Address:** 600 THIRD AVENUE<br>2ND FLOOR<br>NEW YORK, NY 10016

**Form 13F File Number:** 028-13691

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Jin W. Lee<br>**Title:** Chief Compliance Officer<br>**Phone:** 212-601-9792

**Signature, Place, and Date of Signing:**

/s/ Jin W. Lee  New York, NY  04-10-2026<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 76

**Form 13F Information Table Value Total:** $697308424

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| ABBOTT LABORATORIES | COM | 002824100 |  | 19155553 | 186574 | SH |  | SOLE |  | 186574 | 0 | 0 |
| ABIVAX SA | SPONSORED ADS | 00370M103 |  | 15121330 | 135800 | SH |  | SOLE |  | 135800 | 0 | 0 |
| ADAGIO MED HLDGS INC | COM | 00534B100 |  | 1481730 | 1288461 | SH |  | SOLE |  | 1288461 | 0 | 0 |
| ALIGOS THERAPEUTICS INC | COM NEW | 01626L204 |  | 2431371 | 327237 | SH |  | SOLE |  | 327237 | 0 | 0 |
| AN2 THERAPEUTICS INC | COM | 037326105 |  | 2247624 | 657200 | SH |  | SOLE |  | 657200 | 0 | 0 |
| ANI PHARMACEUTICALS INC | COM | 00182C103 |  | 20420257 | 265543 | SH |  | SOLE |  | 265543 | 0 | 0 |
| ANTERIS TECHNOLOGIES GLOBAL | COM | 03675P102 |  | 29875456 | 5382965 | SH |  | SOLE |  | 5382965 | 0 | 0 |
| AQUESTIVE THERAPEUTICS INC | COM | 03843E104 |  | 7979981 | 1922887 | SH |  | SOLE |  | 1922887 | 0 | 0 |
| BIOHAVEN LTD | COM | G1110E107 |  | 9846814 | 1163926 | SH |  | SOLE |  | 1163926 | 0 | 0 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 |  | 10971827 | 194226 | SH |  | SOLE |  | 194226 | 0 | 0 |
| BOUNDLESS BIO INC | COM | 10170A100 |  | 180047 | 163679 | SH |  | SOLE |  | 163679 | 0 | 0 |
| BRIDGEBIO ONCOLOGY THERAPEUT | COM NEW | 107924102 |  | 1169121 | 130628 | SH |  | SOLE |  | 130628 | 0 | 0 |
| BRIGHT MINDS BIOSCIENCES INC | COM NEW | 10919W405 |  | 6281477 | 86083 | SH |  | SOLE |  | 86083 | 0 | 0 |
| CELCUITY INC | COM | 15102K100 |  | 22125240 | 193843 | SH |  | SOLE |  | 193843 | 0 | 0 |
| CENCORA INC | COM | 03073E105 |  | 31694841 | 100894 | SH |  | SOLE |  | 100894 | 0 | 0 |
| CENTENE CORP DEL | COM | 15135B101 |  | 3274000 | 100000 | SH | Put | SOLE |  | 100000 | 0 | 0 |
| COMPASS PATHWAYS PLC | SPONSORED ADS | 20451W101 |  | 8331083 | 1506525 | SH |  | SOLE |  | 1506525 | 0 | 0 |
| CONTEXT THERAPEUTICS INC | COM | 21077P108 |  | 2404956 | 917922 | SH |  | SOLE |  | 917922 | 0 | 0 |
| CORCEPT THERAPEUTICS INC | COM | 218352102 |  | 27199535 | 674759 | SH |  | SOLE |  | 674759 | 0 | 0 |
| CRINETICS PHARMACEUTICALS IN | COM | 22663K107 |  | 9075896 | 249887 | SH |  | SOLE |  | 249887 | 0 | 0 |
| CROSS CTRY HEALTHCARE INC | COM | 227483104 |  | 10324894 | 1098393 | SH |  | SOLE |  | 1098393 | 0 | 0 |
| DIANTHUS THERAPEUTICS INC | COM | 252828108 |  | 31054176 | 370045 | SH |  | SOLE |  | 370045 | 0 | 0 |
| DISC MEDICINE INC | COM | 254604101 |  | 4169080 | 65203 | SH |  | SOLE |  | 65203 | 0 | 0 |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 |  | 8473059 | 268986 | SH |  | SOLE |  | 268986 | 0 | 0 |
| ELICIO THERAPEUTICS INC | COM | 28657F103 |  | 125073 | 11700 | SH | Put | SOLE |  | 11700 | 0 | 0 |
| EMBECTA CORP | COMMON STOCK | 29082K105 |  | 16334994 | 1847850 | SH |  | SOLE |  | 1847850 | 0 | 0 |
| ENANTA PHARMACEUTICALS INC | COM | 29251M106 |  | 505200 | 40000 | SH |  | SOLE |  | 40000 | 0 | 0 |
| ERASCA INC | COM | 29479A108 |  | 80900 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| EYEPOINT INC | COM NEW | 30233G209 |  | 9303809 | 721785 | SH |  | SOLE |  | 721785 | 0 | 0 |
| FOGHORN THERAPEUTICS INC | COM | 344174107 |  | 587409 | 122889 | SH |  | SOLE |  | 122889 | 0 | 0 |
| GSK PLC | SPONSORED ADR | 37733W204 |  | 21296662 | 385879 | SH |  | SOLE |  | 385879 | 0 | 0 |
| HAEMONETICS CORP MASS | COM | 405024100 |  | 12437074 | 220672 | SH |  | SOLE |  | 220672 | 0 | 0 |
| HUMACYTE INC | *W EXP 08/27/202 | 44486Q111 |  | 4572 | 49998 | SH |  | SOLE |  | 49998 | 0 | 0 |
| HYPERFINE INC | COM CL A | 44916K106 |  | 1080000 | 1000000 | SH |  | SOLE |  | 1000000 | 0 | 0 |
| IBIO INC | COM NEW | 451033708 |  | 1718109 | 904268 | SH |  | SOLE |  | 904268 | 0 | 0 |
| ICON PLC | SHS | G4705A100 |  | 33901576 | 306358 | SH |  | SOLE |  | 306358 | 0 | 0 |
| IMMUNOME INC | COM | 45257U108 |  | 3610956 | 165110 | SH |  | SOLE |  | 165110 | 0 | 0 |
| INTEGRA LIFESCIENCES HLDGS C | COM NEW | 457985208 |  | 3609179 | 383140 | SH |  | SOLE |  | 383140 | 0 | 0 |
| KYMERA THERAPEUTICS INC | COM | 501575104 |  | 2684853 | 32235 | SH |  | SOLE |  | 32235 | 0 | 0 |
| LIVANOVA PLC | SHS | G5509L101 |  | 26797849 | 421615 | SH |  | SOLE |  | 421615 | 0 | 0 |
| MAXIMUS INC | COM | 577933104 |  | 49281683 | 768825 | SH |  | SOLE |  | 768825 | 0 | 0 |
| MODULAR MED INC | COM NEW | 60785L306 |  | 138283 | 26190 | SH |  | SOLE |  | 26190 | 0 | 0 |
| MONOPAR THERAPEUTICS INC | COM NEW | 61023L207 |  | 9506394 | 173506 | SH |  | SOLE |  | 173506 | 0 | 0 |
| NEUROONE MED TECHNOLOGIES CO | COM NEW | 64130M209 |  | 385621 | 496614 | SH |  | SOLE |  | 496614 | 0 | 0 |
| NYXOAH S A | SHS | B6S7WD106 |  | 148450 | 50839 | SH |  | SOLE |  | 50839 | 0 | 0 |
| OCULAR THERAPEUTIX INC | COM | 67576A100 |  | 8204017 | 968597 | SH |  | SOLE |  | 968597 | 0 | 0 |
| ONKURE THERAPEUTICS INC | COM CL A | 68277Q105 |  | 4466915 | 1078965 | SH |  | SOLE |  | 1078965 | 0 | 0 |
| ORGANON  CO | COMMON STOCK | 68622V106 |  | 5186789 | 865908 | SH |  | SOLE |  | 865908 | 0 | 0 |
| ORUKA THERAPEUTICS INC | COM | 687604108 |  | 6498929 | 132496 | SH |  | SOLE |  | 132496 | 0 | 0 |
| OSCAR HEALTH INC | CL A | 687793109 |  | 34410 | 3000 | SH | Put | SOLE |  | 3000 | 0 | 0 |
| OVID THERAPEUTICS INC | COM | 690469101 |  | 2780286 | 1252381 | SH |  | SOLE |  | 1252381 | 0 | 0 |
| PMV PHARMACEUTICALS INC | COM | 69353Y103 |  | 3814959 | 3076580 | SH |  | SOLE |  | 3076580 | 0 | 0 |
| PROQR THERAPEUTICS N V | SHS EURO | N71542109 |  | 3166638 | 1954715 | SH |  | SOLE |  | 1954715 | 0 | 0 |
| PROTARA THERAPEUTICS INC | COM STK | 74365U107 |  | 10262861 | 1969839 | SH |  | SOLE |  | 1969839 | 0 | 0 |
| QUIDELORTHO CORP | COM | 219798105 |  | 5898551 | 359011 | SH |  | SOLE |  | 359011 | 0 | 0 |
| RAPPORT THERAPEUTICS INC | COM | 75383L102 |  | 11477454 | 366809 | SH |  | SOLE |  | 366809 | 0 | 0 |
| RELMADA THERAPEUTICS INC | COM | 75955J402 |  | 6716400 | 965000 | SH |  | SOLE |  | 965000 | 0 | 0 |
| REPLIMUNE GROUP INC | COM | 76029N106 |  | 5508275 | 720036 | SH |  | SOLE |  | 720036 | 0 | 0 |
| ROCKET PHARMACEUTICALS INC | *W EXP 09/02/202 | 77313F114 |  | 7020 | 400000 | SH |  | SOLE |  | 400000 | 0 | 0 |
| SANOFI SA | SPONSORED ADR | 80105N105 |  | 11547349 | 239671 | SH |  | SOLE |  | 239671 | 0 | 0 |
| SAVARA INC | COM | 805111101 |  | 3351828 | 613888 | SH |  | SOLE |  | 613888 | 0 | 0 |
| SENSEONICS HLDGS INC | COM | 81727U303 |  | 771121 | 115784 | SH |  | SOLE |  | 115784 | 0 | 0 |
| SERINA THERAPEUTICS INC | COM SHS | 81751A108 |  | 1940000 | 1000000 | SH |  | SOLE |  | 1000000 | 0 | 0 |
| SHOULDER INNOVATIONS INC | COMMON STOCK | 82537J108 |  | 3060614 | 210641 | SH |  | SOLE |  | 210641 | 0 | 0 |
| SIMULATIONS PLUS INC | COM | 829214105 |  | 2364 | 200 | SH |  | SOLE |  | 200 | 0 | 0 |
| SIONNA THERAPEUTICS INC | COM | 829401108 |  | 11800091 | 294340 | SH |  | SOLE |  | 294340 | 0 | 0 |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 |  | 10078283 | 209093 | SH |  | SOLE |  | 209093 | 0 | 0 |
| TELA BIO INC | COM | 872381108 |  | 394506 | 636300 | SH |  | SOLE |  | 636300 | 0 | 0 |
| TELEFLEX INCORPORATED | COM | 879369106 |  | 11339028 | 94800 | SH |  | SOLE |  | 94800 | 0 | 0 |
| TERNS PHARMACEUTICALS INC | COM | 880881107 |  | 532472 | 10100 | SH |  | SOLE |  | 10100 | 0 | 0 |
| TYRA BIOSCIENCES INC | COM | 90240B106 |  | 23188314 | 605439 | SH |  | SOLE |  | 605439 | 0 | 0 |
| VIR BIOTECHNOLOGY INC | COM | 92764N102 |  | 13427635 | 1498620 | SH |  | SOLE |  | 1498620 | 0 | 0 |
| WAYSTAR HLDG CORP | COM | 946784105 |  | 39594310 | 1642236 | SH |  | SOLE |  | 1642236 | 0 | 0 |
| XILIO THERAPEUTICS INC | COM | 98422T209 |  | 1282222 | 152464 | SH |  | SOLE |  | 152464 | 0 | 0 |
| ZENAS BIOPHARMA INC | COM | 98937L105 |  | 6485322 | 331730 | SH |  | SOLE |  | 331730 | 0 | 0 |
| ZIMMER BIOMET HOLDINGS INC | COM | 98956P102 |  | 5661467 | 62613 | SH |  | SOLE |  | 62613 | 0 | 0 |

---