# EDGAR Filing Document

**Accession Number:** 0000872625
**File Stem:** 0002071691-25-009319
**Filing Date:** 2025-12
**Character Count:** 38650
**Document Hash:** f3acb95de210edcb1440f404f671c42c
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0002071691-25-009319.hdr.sgml**: 20251223

**ACCESSION NUMBER**: 0002071691-25-009319

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20251031

**FILED AS OF DATE**: 20251223

**DATE AS OF CHANGE**: 20251223

**PERIOD START**: 20260430

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** FRANKLIN STRATEGIC SERIES
- **CENTRAL INDEX KEY:** 0000872625

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** FL
- **FISCAL YEAR END:** 0430

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-06243
- **FILM NUMBER:** 251595218

**BUSINESS ADDRESS:**
- **STREET 1:** ONE FRANKLIN PARKWAY
- **CITY:** SAN MATEO
- **STATE:** CA
- **ZIP:** 94403-1906
- **BUSINESS PHONE:** 650-570-3000

**MAIL ADDRESS:**
- **STREET 1:** ONE FRANKLIN PARKWAY
- **CITY:** SAN MATEO
- **STATE:** CA
- **ZIP:** 94403-1906

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** FRANKLIN CALIFORNIA 250 GROWTH FUND
- **DATE OF NAME CHANGE:** 19911216

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** FRANKLIN CALIFORNIA 250 GROWTH INDEX FUND
- **DATE OF NAME CHANGE:** 19910917

## Series and Classes Contracts Data

### FRANKLIN BIOTECHNOLOGY DISCOVERY FUND (Series ID: S000006882)

| Class ID   | Class Name    | Ticker Symbol   |
|:---|:---|:---|
| C000018631 | CLASS A       | FBDIX           |
| C000081539 | ADVISOR CLASS | FTDZX           |
| C000128862 | Class R6      | FRBRX           |
| C000141458 | Class C       | FBTDX           |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** Franklin Strategic Series

- **b. Investment Company Act file number:** 811-06243

- **c. CIK number of Registrant:** 0000872625

- **d. LEI of Registrant:** 549300NDWC0J6DXVSX36

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** One Franklin Parkway

  - **City:** San Mateo

  - **State:** CA

  - **Foreign country:** US

  - **Zip / Postal Code:** 94403-1906

  - **Telephone number:** 650-312-2000

**Item A.2. Information about the Series.**

- **a. Name of Series:** Franklin Biotechnology Discovery Fund

- **b. EDGAR series identifier (if any):** S000006882

- **c. LEI of Series:** 6N5133EDK315FXQQM036

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2026-04-30

- **b. Date as of which information is reported:** 2025-10-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $988258456.06

**Total Liabilities:** $34115262.34

**Net Assets:** $954143193.72

**Cash Not Reported:** $4975900.41

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000128862 | 6.79%                | 11.24%               | 13.16%               |
| Class ID C000018631 | 6.75%                | 11.21%               | 13.13%               |
| Class ID C000081539 | 6.77%                | 11.24%               | 13.15%               |
| Class ID C000141458 | 6.69%                | 11.14%               | 13.05%               |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $2922875.62              | $45796334.91                               |
| Month 2  | $31576505.78             | $54041700.14                               |
| Month 3  | $4100533.60              | $107202809.86                              |

### Schedule of Portfolio Investments

| Name                                                     | Title                                                    | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Apogee Therapeutics, Inc.                                | Apogee Therapeutics, Inc.                                | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     82737 | NS      | $4682086.83   | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Ionis Pharmaceuticals, Inc.                              | Ionis Pharmaceuticals, Inc.                              | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |    104249 | NS      | $7745700.70   | 0.81%             |  |  |  | No            |                  1 | On Loan: No      |
| Solid Biosciences, Inc.                                  | Solid Biosciences, Inc.                                  | CUSIP: 83422E204<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    566700 | NS      | $3054513.00   | 0.32%             |  |  |  | No            |                  1 | On Loan: No      |
| uniQure NV                                               | uniQure NV                                               | CUSIP: N/A<br>LEI: 724500RPCTZLFYJZ3S98       | Long             | EC               | CORP              | NL        |    372542 | NS      | $25217367.98  | 2.64%             |  |  |  | No            |                  1 | On Loan: No      |
| ORIC Pharmaceuticals, Inc.                               | ORIC Pharmaceuticals, Inc.                               | CUSIP: 68622P109<br>LEI: 54930033FJRNEYBW0L25 | Long             | EC               | CORP              | US        |    402121 | NS      | $5291912.36   | 0.55%             |  |  |  | No            |                  1 | On Loan: No      |
| Tango Therapeutics, Inc.                                 | Tango Therapeutics, Inc.                                 | CUSIP: 87583X109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    364265 | NS      | $2954189.15   | 0.31%             |  |  |  | No            |                  1 | On Loan: —       |
| Jazz Pharmaceuticals plc                                 | Jazz Pharmaceuticals plc                                 | CUSIP: N/A<br>LEI: 635400GAUMJCLEZRRV50       | Long             | EC               | CORP              | IE        |    278505 | NS      | $38333428.20  | 4.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Eli Lilly & Co.                                          | Eli Lilly & Co.                                          | CUSIP: 532457108<br>LEI: FRDRIPF3EKNDJ2CQJL29 | Long             | EC               | CORP              | US        |     14071 | NS      | $12141303.06  | 1.27%             |  |  |  | No            |                  1 | On Loan: No      |
| Amylyx Pharmaceuticals, Inc.                             | Amylyx Pharmaceuticals, Inc.                             | CUSIP: 03237H101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    370129 | NS      | $5155896.97   | 0.54%             |  |  |  | No            |                  1 | On Loan: No      |
| Mineralys Therapeutics, Inc.                             | Mineralys Therapeutics, Inc.                             | CUSIP: 603170101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    645332 | NS      | $26368265.52  | 2.76%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences, Inc.                             | Neurocrine Biosciences, Inc.                             | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |    135273 | NS      | $19372446.33  | 2.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Achieve Life Sciences, Inc.                              | Achieve Life Sciences, Inc.                              | CUSIP: N/A<br>LEI: 549300V82ZKZDTAU0A46       | Long             |  | CORP              | US        |    698900 | NS      | $1681148.04   | 0.18%             |  |  |  | No            |                  3 | On Loan: No      |
| Insmed, Inc.                                             | Insmed, Inc.                                             | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |    188633 | NS      | $35764816.80  | 3.75%             |  |  |  | No            |                  1 | On Loan: No      |
| Dyne Therapeutics, Inc.                                  | Dyne Therapeutics, Inc.                                  | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    425742 | NS      | $9613254.36   | 1.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Zealand Pharma A/S                                       | Zealand Pharma A/S, Class A                              | CUSIP: N/A<br>LEI: 549300ITBB1ULBL4CZ12       | Long             | EC               | CORP              | DK        |     69700 | NS      | $5518467.17   | 0.58%             |  |  |  | No            |                  2 | On Loan: No      |
| Soleno Therapeutics, Inc.                                | Soleno Therapeutics, Inc.                                | CUSIP: 834203309<br>LEI: 5493003LCY77N7FXK844 | Long             | EC               | CORP              | US        |    175992 | NS      | $11819622.72  | 1.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Sartorius Stedim Biotech                                 | Sartorius Stedim Biotech                                 | CUSIP: N/A<br>LEI: 52990006IVXY7GCSSR39       | Long             | EC               | CORP              | FR        |     10100 | NS      | $2415612.02   | 0.25%             |  |  |  | No            |                  2 | On Loan: No      |
| Sartorius AG                                             | Sartorius AG                                             | CUSIP: N/A<br>LEI: 529900EQV2DY4FOAMU38       | Long             | EP               | CORP              | DE        |      9200 | NS      | $2531177.77   | 0.27%             |  |  |  | No            |                  2 | On Loan: No      |
| Benitec Biopharma, Inc.                                  | Benitec Biopharma, Inc.                                  | CUSIP: 08205P209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    995152 | NS      | $16280686.72  | 1.71%             |  |  |  | No            |                  1 | On Loan: No      |
| Danish Krone                                             | Danish Krone                                             | CUSIP: N/A<br>LEI: N/A                        | Long             | STIV             |  | DK        |       740 | OU      | $114.21       | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Argenx SE                                                | Argenx SE                                                | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |     48212 | NS      | $39461522.00  | 4.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Aura Biosciences, Inc.                                   | Aura Biosciences, Inc.                                   | CUSIP: 05153U107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    765617 | NS      | $4693232.21   | 0.49%             |  |  |  | No            |                  1 | On Loan: —       |
| Olema Pharmaceuticals, Inc.                              | Olema Pharmaceuticals, Inc.                              | CUSIP: 68062P106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     94989 | NS      | $852051.33    | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Revolution Medicines, Inc.                               | Revolution Medicines, Inc.                               | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |    226850 | NS      | $13347854.00  | 1.40%             |  |  |  | No            |                  1 | On Loan: No      |
| Candid, Inc.                                             | Candid, Inc., Series B                                   | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |   1519609 | NS      | $2154744.78   | 0.23%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Contineum Therapeutics, Inc.                             | Contineum Therapeutics, Inc., Class A                    | CUSIP: 21217B100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    287221 | NS      | $3162303.21   | 0.33%             |  |  |  | No            |                  1 | On Loan: No      |
| Engene Holdings, Inc.                                    | Engene Holdings, Inc.                                    | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | CA        |    272359 | NS      | $1963708.39   | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Ideaya Biosciences, Inc.                                 | Ideaya Biosciences, Inc.                                 | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |     81852 | NS      | $2607804.72   | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| Dianthus Therapeutics, Inc.                              | Dianthus Therapeutics, Inc.                              | CUSIP: 252828108<br>LEI: 549300Z3N6ODPCOFC890 | Long             | EC               | CORP              | US        |    157456 | NS      | $5507810.88   | 0.58%             |  |  |  | No            |                  1 | On Loan: No      |
| Praxis Precision Medicines, Inc.                         | Praxis Precision Medicines, Inc.                         | CUSIP: 74006W207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    147931 | NS      | $29402765.56  | 3.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytokinetics, Inc.                                       | Cytokinetics, Inc.                                       | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |     50600 | NS      | $3217654.00   | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Satellos Bioscience, Inc.                                | Satellos Bioscience, Inc.                                | CUSIP: 80401L308<br>LEI: 529900EN243BZ5QC9N39 | Long             | EC               | CORP              | CA        |   1161960 | NS      | $637916.08    | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Palisade Bio, Inc.                                       | Palisade Bio, Inc.                                       | CUSIP: 696389154<br>LEI: 549300W6LIDX3I5XXT34 | Long             |  | CORP              | US        |   1447549 | NS      | $2996281.68   | 0.31%             |  |  |  | No            |                  3 | On Loan: No      |
| Day One Biopharmaceuticals, Inc.                         | Day One Biopharmaceuticals, Inc.                         | CUSIP: 23954D109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    851469 | NS      | $6334929.36   | 0.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Centessa Pharmaceuticals plc                             | Centessa Pharmaceuticals plc                             | CUSIP: 152309100<br>LEI: 213800GIDAARDSKOI827 | Long             | EC               | CORP              | GB        |    402950 | NS      | $10033455.00  | 1.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Lycia LLC                                                | Lycia LLC, Series C                                      | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | JP        |    859370 | NS      | $2217006.16   | 0.23%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Xenon Pharmaceuticals, Inc.                              | Xenon Pharmaceuticals, Inc.                              | CUSIP: 98420N105<br>LEI: 549300XV44Q9Z1MIPQ03 | Long             | EC               | CORP              | CA        |     93364 | NS      | $3913818.88   | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC Therapeutics, Inc.                                   | PTC Therapeutics, Inc.                                   | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |    376675 | NS      | $25730669.25  | 2.70%             |  |  |  | No            |                  1 | On Loan: No      |
| Ultragenyx Pharmaceutical, Inc.                          | Ultragenyx Pharmaceutical, Inc.                          | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |    209262 | NS      | $7240465.20   | 0.76%             |  |  |  | No            |                  1 | On Loan: No      |
| Bicara Therapeutics, Inc.                                | Bicara Therapeutics, Inc.                                | CUSIP: 055477103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    373001 | NS      | $6061266.25   | 0.64%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvalent, Inc.                                           | Nuvalent, Inc., Class A                                  | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     70149 | NS      | $6967198.68   | 0.73%             |  |  |  | No            |                  1 | On Loan: No      |
| Mirum Pharmaceuticals, Inc.                              | Mirum Pharmaceuticals, Inc.                              | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |    215190 | NS      | $15633553.50  | 1.64%             |  |  |  | No            |                  1 | On Loan: No      |
| AstraZeneca plc                                          | AstraZeneca plc                                          | CUSIP: 046353108<br>LEI: PY6ZZQWO2IZFZC3IOL08 | Long             | EC               | CORP              | GB        |    205062 | NS      | $16897108.80  | 1.77%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcutis Biotherapeutics, Inc.                            | Arcutis Biotherapeutics, Inc.                            | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    505651 | NS      | $12798026.81  | 1.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvation Bio, Inc.                                       | Nuvation Bio, Inc.                                       | CUSIP: 67080N119<br>LEI: N/A                  | Long             |  | CORP              | US        |    115266 | NS      | $12633.15     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Abivax SA                                                | Abivax SA                                                | CUSIP: 00370M103<br>LEI: 969500D8TMNB184OJU95 | Long             | EC               | CORP              | FR        |    173710 | NS      | $17791378.20  | 1.86%             |  |  |  | No            |                  1 | On Loan: No      |
| CG oncology, Inc.                                        | CG oncology, Inc.                                        | CUSIP: 156944100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    237449 | NS      | $10274418.23  | 1.08%             |  |  |  | No            |                  1 | On Loan: No      |
| MBX Biosciences, Inc.                                    | MBX Biosciences, Inc.                                    | CUSIP: 55287L101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    323190 | NS      | $7097252.40   | 0.74%             |  |  |  | No            |                  1 | On Loan: No      |
| Syndax Pharmaceuticals, Inc.                             | Syndax Pharmaceuticals, Inc.                             | CUSIP: 87164F105<br>LEI: 529900OF94TRHKZVBS87 | Long             | EC               | CORP              | US        |    551449 | NS      | $7554851.30   | 0.79%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals, Inc.                            | Alnylam Pharmaceuticals, Inc.                            | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |     80124 | NS      | $36539748.96  | 3.83%             |  |  |  | No            |                  1 | On Loan: No      |
| Context Therapeutics, Inc.                               | Context Therapeutics, Inc.                               | CUSIP: 21077P108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1479200 | NS      | $1612328.00   | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Ascendis Pharma A/S                                      | Ascendis Pharma A/S                                      | CUSIP: 04351P101<br>LEI: 549300B66JN3W3J8GH73 | Long             | EC               | CORP              | DK        |    129742 | NS      | $26155987.20  | 2.74%             |  |  |  | No            |                  1 | On Loan: No      |
| Oruka Therapeutics, Inc.                                 | Oruka Therapeutics, Inc.                                 | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |    117457 | NS      | $3308763.69   | 0.35%             |  |  |  | No            |                  1 | On Loan: —       |
| Oruka Therapeutics, Inc.                                 | Oruka Therapeutics, Inc.                                 | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |    249964 | NS      | $7041485.88   | 0.74%             |  |  |  | No            |                  1 | On Loan: No      |
| Assembly Biosciences, Inc.                               | Assembly Biosciences, Inc.                               | CUSIP: 045396207<br>LEI: 5299007Y1X8RBDFT8C40 | Long             | EC               | CORP              | US        |     88900 | NS      | $2760345.00   | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Newamsterdam Pharma Co. NV                               | Newamsterdam Pharma Co. NV                               | CUSIP: N/A<br>LEI: 984500B6549TF6E14D36       | Long             | EC               | CORP              | NL        |    166376 | NS      | $6313969.20   | 0.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Olema Pharmaceuticals, Inc.                              | Olema Pharmaceuticals, Inc.                              | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |    677200 | NS      | $6074484.00   | 0.64%             |  |  |  | No            |                  1 | On Loan: No      |
| AnaptysBio, Inc.                                         | AnaptysBio, Inc.                                         | CUSIP: 032724106<br>LEI: 529900HH4WQT03IG1A12 | Long             | EC               | CORP              | US        |    128979 | NS      | $4718051.82   | 0.49%             |  |  |  | No            |                  1 | On Loan: —       |
| Alto Neuroscience, Inc.                                  | Alto Neuroscience, Inc.                                  | CUSIP: 02157Q109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    240205 | NS      | $3408508.95   | 0.36%             |  |  |  | No            |                  1 | On Loan: —       |
| Structure Therapeutics, Inc.                             | Structure Therapeutics, Inc.                             | CUSIP: 86366E106<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |     34633 | NS      | $1153971.56   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Applied Therapeutics, Inc.                               | Applied Therapeutics, Inc.                               | CUSIP: 03828A101<br>LEI: 549300KL3IJPHZM2GR04 | Long             | EC               | CORP              | US        |    740200 | NS      | $851230.00    | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Vertex Pharmaceuticals, Inc.                             | Vertex Pharmaceuticals, Inc.                             | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |    102150 | NS      | $43471975.50  | 4.56%             |  |  |  | No            |                  1 | On Loan: No      |
| Adicet Bio, Inc.                                         | Adicet Bio, Inc.                                         | CUSIP: 007002108<br>LEI: 549300VRD2QO80WBOP18 | Long             | EC               | CORP              | US        |   3602981 | NS      | $2702235.75   | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| ARS Pharmaceuticals, Inc.                                | ARS Pharmaceuticals, Inc.                                | CUSIP: 82835W108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    875559 | NS      | $7845008.64   | 0.82%             |  |  |  | No            |                  1 | On Loan: —       |
| LENZ Therapeutics, Inc.                                  | LENZ Therapeutics, Inc.                                  | CUSIP: 52635N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    237894 | NS      | $7070209.68   | 0.74%             |  |  |  | No            |                  1 | On Loan: —       |
| Artiva Biotherapeutics, Inc.                             | Artiva Biotherapeutics, Inc.                             | CUSIP: 04317A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    192871 | NS      | $804272.07    | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Assembly Biosciences, Inc.                               | Assembly Biosciences, Inc., Series A                     | CUSIP: N/A<br>LEI: 5299007Y1X8RBDFT8C40       | Long             | EC               | CORP              | US        |     44450 | NS      | $611778.51    | 0.06%             |  |  |  | No            |                  3 | On Loan: No      |
| Carmot Therapeutics, Inc.                                | Carmot Therapeutics, Inc.                                | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |     83100 | NS      | $435454.47    | 0.05%             |  |  |  | No            |                  3 | On Loan: No      |
| Acumen Pharmaceuticals, Inc.                             | Acumen Pharmaceuticals, Inc.                             | CUSIP: 00509G209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    826400 | NS      | $1826344.00   | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Franklin Institutional U.S. Government Money Market Fund | Franklin Institutional U.S. Government Money Market Fund | CUSIP: 8611239C3<br>LEI: N/A                  | Long             | STIV             | RF                | US        |  33119640 | NS      | $33119640.25  | 3.47%             |  |  |  | No            |                  1 | On Loan: No      |
| EyePoint Pharmaceuticals, Inc.                           | EyePoint Pharmaceuticals, Inc.                           | CUSIP: 30233G209<br>LEI: 549300QE1RU34T50MR69 | Long             | EC               | CORP              | US        |   1181255 | NS      | $15462627.95  | 1.62%             |  |  |  | No            |                  1 | On Loan: No      |
| Bridgebio Pharma, Inc.                                   | Bridgebio Pharma, Inc.                                   | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |    202124 | NS      | $12661047.36  | 1.33%             |  |  |  | No            |                  1 | On Loan: No      |
| Spyre Therapeutics, Inc.                                 | Spyre Therapeutics, Inc.                                 | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |    220000 | NS      | $5381200.00   | 0.56%             |  |  |  | No            |                  1 | On Loan: No      |
| Achieve Life Sciences, Inc.                              | Achieve Life Sciences, Inc.                              | CUSIP: 004468500<br>LEI: 549300V82ZKZDTAU0A46 | Long             | EC               | CORP              | US        |   1575682 | NS      | $8067491.84   | 0.85%             |  |  |  | No            |                  1 | On Loan: —       |
| BeOne Medicines Ltd.                                     | BeOne Medicines Ltd.                                     | CUSIP: 07725L102<br>LEI: 549300JFUK6FRD5MH739 | Long             | EC               | CORP              | CH        |     14276 | NS      | $4432412.48   | 0.46%             |  |  |  | No            |                  1 | On Loan: No      |
| Centessa Pharmaceuticals plc                             | Centessa Pharmaceuticals plc                             | CUSIP: 152309100<br>LEI: 213800GIDAARDSKOI827 | Long             | EC               | CORP              | GB        |    189736 | NS      | $4724426.40   | 0.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Amgen, Inc.                                              | Amgen, Inc.                                              | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |    143458 | NS      | $42812170.94  | 4.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Palisade Bio, Inc.                                       | Palisade Bio, Inc.                                       | CUSIP: 696389402<br>LEI: 549300W6LIDX3I5XXT34 | Long             | EC               | CORP              | US        |   1599923 | NS      | $3311840.61   | 0.35%             |  |  |  | No            |                  1 | On Loan: —       |
| IN8bio, Inc.                                             | IN8bio, Inc.                                             | CUSIP: 45674E208<br>LEI: 549300H68IVCRKSGSL94 | Long             | EC               | CORP              | US        |     69673 | NS      | $135862.35    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Spyre Therapeutics, Inc.                                 | Spyre Therapeutics, Inc.                                 | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |    176281 | NS      | $4311833.26   | 0.45%             |  |  |  | No            |                  1 | On Loan: —       |
| Assembly Biosciences, Inc.                               | Assembly Biosciences, Inc., Series B                     | CUSIP: N/A<br>LEI: 5299007Y1X8RBDFT8C40       | Long             | EC               | CORP              | US        |     44450 | NS      | $46895.02     | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| IN8bio, Inc.                                             | IN8bio, Inc., Series C                                   | CUSIP: N/A<br>LEI: 549300H68IVCRKSGSL94       | Long             |  | CORP              | US        |     69673 | NS      | $2817.44      | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Regeneron Pharmaceuticals, Inc.                          | Regeneron Pharmaceuticals, Inc.                          | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |     59922 | NS      | $39057159.60  | 4.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Gilead Sciences, Inc.                                    | Gilead Sciences, Inc.                                    | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |    443663 | NS      | $53146390.77  | 5.57%             |  |  |  | No            |                  1 | On Loan: No      |
| Thermo Fisher Scientific, Inc.                           | Thermo Fisher Scientific, Inc.                           | CUSIP: 883556102<br>LEI: HCHV7422L5HDJZCRFL38 | Long             | EC               | CORP              | US        |      8579 | NS      | $4867638.81   | 0.51%             |  |  |  | No            |                  1 | On Loan: No      |
| Guardant Health, Inc.                                    | Guardant Health, Inc.                                    | CUSIP: 40131M109<br>LEI: 254900M8C3E5VC8BR186 | Long             | EC               | CORP              | US        |    265916 | NS      | $24735506.32  | 2.59%             |  |  |  | No            |                  1 | On Loan: No      |
| Structure Therapeutics, Inc.                             | Structure Therapeutics, Inc.                             | CUSIP: 86366E106<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |    159221 | NS      | $5305243.72   | 0.56%             |  |  |  | No            |                  1 | On Loan: No      |
| Franklin Institutional U.S. Government Money Market Fund | Franklin Institutional U.S. Government Money Market Fund | CUSIP: 457756500<br>LEI: 549300M4TP89K77LG374 | Long             | STIV             | RF                | US        |  36072290 | NS      | $36072289.53  | 3.78%             |  |  |  | No            |                  1 | On Loan: No      |
| Sanofi SA                                                | Sanofi SA, Escrow Account                                | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | CO        |   2333755 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Contineum Therapeutics, Inc.                             | Contineum Therapeutics, Inc., Class A                    | CUSIP: 21217B100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    295058 | NS      | $3248588.58   | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Sionna Therapeutics, Inc.                                | Sionna Therapeutics, Inc.                                | CUSIP: 829401108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     84606 | NS      | $3232795.26   | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Benitec Biopharma, Inc.                                  | Benitec Biopharma, Inc.                                  | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |    310881 | NS      | $5085982.07   | 0.53%             |  |  |  | No            |                  2 | On Loan: No      |
| Alto Neuroscience, Inc.                                  | Alto Neuroscience, Inc.                                  | CUSIP: 02157Q109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    165070 | NS      | $2342343.30   | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Engene Holdings, Inc.                                    | Engene Holdings, Inc.                                    | CUSIP: 29286M105<br>LEI: N/A                  | Long             | EC               | CORP              | CA        |     87100 | NS      | $627991.00    | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Terns Pharmaceuticals, Inc.                              | Terns Pharmaceuticals, Inc.                              | CUSIP: 880881107<br>LEI: 254900S1ZDQMF4MYP709 | Long             | EC               | CORP              | US        |    449500 | NS      | $3712870.00   | 0.39%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2025-12-01

**Name of Applicant:** Franklin Strategic Series

**Signature:** Monica Krogh

**Name of Signer:** Monica Krogh

**Title:** Assistant Treasurer