# EDGAR Filing Document

**Accession Number:** 0001383496
**File Stem:** 0001752724-23-065194
**Filing Date:** 2023-3
**Character Count:** 34878
**Document Hash:** 207ced1b04fefc0a8ac237bd575f7e8c
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001752724-23-065194.hdr.sgml**: 20230324

**ACCESSION NUMBER**: 0001752724-23-065194

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20230131

**FILED AS OF DATE**: 20230324

**DATE AS OF CHANGE**: 20230324

**PERIOD START**: 20230731

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** FIRST TRUST EXCHANGE-TRADED ALPHADEX FUND
- **CENTRAL INDEX KEY:** 0001383496
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** MA

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-22019
- **FILM NUMBER:** 23758491

**BUSINESS ADDRESS:**
- **STREET 1:** 120 EAST LIBERTY DRIVE, SUITE 400
- **CITY:** WHEATON
- **STATE:** IL
- **ZIP:** 60187
- **BUSINESS PHONE:** 630-765-8000

**MAIL ADDRESS:**
- **STREET 1:** 120 EAST LIBERTY DRIVE, SUITE 400
- **CITY:** WHEATON
- **STATE:** IL
- **ZIP:** 60187

## Series and Classes Contracts Data

### First Trust Health Care AlphaDEX Fund (Series ID: S000017700)

| Class ID   | Class Name                            | Ticker Symbol   |
|:---|:---|:---|
| C000048900 | First Trust Health Care AlphaDEX Fund | FXH             |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** First Trust Exchange-Traded AlphaDEX Fund

- **b. Investment Company Act file number:** 811-22019

- **c. CIK number of Registrant:** 0001383496

- **d. LEI of Registrant:** 549300PGRVU1P76W4537

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 120 East Liberty Drive

  - **City:** Wheaton

  - **State:** IL

  - **Foreign country:** US

  - **Zip / Postal Code:** 60187

  - **Telephone number:** 630-765-8000

**Item A.2. Information about the Series.**

- **a. Name of Series:** First Trust Health Care AlphaDEX Fund

- **b. EDGAR series identifier (if any):** S000017700

- **c. LEI of Series:** 5493009VIGFPXQC5HK94

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2023-07-31

- **b. Date as of which information is reported:** 2023-01-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $1670133165.65

**Total Liabilities:** $7625334.11

**Net Assets:** $1662507831.54

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000048900 | 4.75%                | -0.65%               | 3.34%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $1372082.90              | $69260567.35                               |
| Month 2  | $4350478.34              | $-15069955.63                              |
| Month 3  | $-29234573.72            | $82449706.66                               |

### Schedule of Portfolio Investments

| Name                                                     | Title                                                    | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Stryker Corp                                             | Stryker Corp                                             | CUSIP: 863667101<br>LEI: 5493002F0SC4JTBU5137 | Long             | EC               | CORP              | US        |     82245 | NS      | $20874603.45  | 1.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Doximity Inc                                             | Doximity Inc                                             | CUSIP: 26622P107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    187973 | NS      | $6629807.71   | 0.40%             |  |  |  | No            |                  1 | On Loan: No      |
| BNP Paribas Securities Corp                              | BNP Paribas Securities Corp                              | CUSIP: 000000000<br>LEI: RCNB6OTYUAMMP879YW96 | Long             | RA               | CORP              | US        |   1014466 | PA      | $1014465.88   | 0.06%             |  |  |  | No            |                  2 | On Loan: No      |
| United Therapeutics Corp                                 | United Therapeutics Corp                                 | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |     90741 | NS      | $23880308.97  | 1.44%             |  |  |  | No            |                  1 | On Loan: No      |
| Signify Health Inc                                       | Signify Health Inc                                       | CUSIP: 82671G100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    440220 | NS      | $12528661.20  | 0.75%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen Inc                                               | Biogen Inc                                               | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |     91123 | NS      | $26507680.70  | 1.59%             |  |  |  | No            |                  1 | On Loan: No      |
| Humana Inc                                               | Humana Inc                                               | CUSIP: 444859102<br>LEI: 529900YLDW34GJAO4J06 | Long             | EC               | CORP              | US        |     49263 | NS      | $25207877.10  | 1.52%             |  |  |  | No            |                  1 | On Loan: No      |
| Premier Inc                                              | Premier Inc                                              | CUSIP: 74051N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    721369 | NS      | $24064869.84  | 1.45%             |  |  |  | No            |                  1 | On Loan: No      |
| MSILF Treasury Portfolio                                 | MSILF Treasury Portfolio                                 | CUSIP: 61747C582<br>LEI: 549300D1XR6GP7EZ0T47 | Long             | STIV             | RF                | US        |   2832151 | NS      | $2832150.73   | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Acadia Healthcare Co Inc                                 | Acadia Healthcare Co Inc                                 | CUSIP: 00404A109<br>LEI: 5493005CW985Y9D0NC11 | Long             | EC               | CORP              | US        |    153266 | NS      | $12877409.32  | 0.77%             |  |  |  | No            |                  1 | On Loan: No      |
| Bristol-Myers Squibb Co                                  | Bristol-Myers Squibb Co                                  | CUSIP: 110122108<br>LEI: HLYYNH7UQUORYSJQCN42 | Long             | EC               | CORP              | US        |    279470 | NS      | $20303495.50  | 1.22%             |  |  |  | No            |                  1 | On Loan: No      |
| PerkinElmer Inc                                          | PerkinElmer Inc                                          | CUSIP: 714046109<br>LEI: 549300IKL1SDPFI7N655 | Long             | EC               | CORP              | US        |     89978 | NS      | $12374674.34  | 0.74%             |  |  |  | No            |                  1 | On Loan: No      |
| UnitedHealth Group Inc                                   | UnitedHealth Group Inc                                   | CUSIP: 91324P102<br>LEI: 549300GHBMY8T5GXDE41 | Long             | EC               | CORP              | US        |     37926 | NS      | $18932279.94  | 1.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Danaher Corp                                             | Danaher Corp                                             | CUSIP: 235851102<br>LEI: S4BKK9OTCEWQ3YHPFM11 | Long             | EC               | CORP              | US        |     47538 | NS      | $12568096.44  | 0.76%             |  |  |  | No            |                  1 | On Loan: No      |
| Intuitive Surgical Inc                                   | Intuitive Surgical Inc                                   | CUSIP: 46120E602<br>LEI: 54930052SRG011710797 | Long             | EC               | CORP              | US        |     75779 | NS      | $18618142.51  | 1.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Centene Corp                                             | Centene Corp                                             | CUSIP: 15135B101<br>LEI: 549300Z7JJ4TQSQGT333 | Long             | EC               | CORP              | US        |    245187 | NS      | $18693056.88  | 1.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Penumbra Inc                                             | Penumbra Inc                                             | CUSIP: 70975L107<br>LEI: 549300RGE06P3ECANU72 | Long             | EC               | CORP              | US        |     90387 | NS      | $22633808.67  | 1.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Novavax Inc                                              | Novavax Inc                                              | CUSIP: 670002401<br>LEI: 529900J4GJHPEPQ23205 | Long             | EC               | CORP              | US        |    613654 | NS      | $6694965.14   | 0.40%             |  |  |  | No            |                  1 | On Loan: —       |
| Pfizer Inc                                               | Pfizer Inc                                               | CUSIP: 717081103<br>LEI: 765LHXWGK1KXCLTFYQ30 | Long             | EC               | CORP              | US        |    654047 | NS      | $28882715.52  | 1.74%             |  |  |  | No            |                  1 | On Loan: No      |
| Regeneron Pharmaceuticals Inc                            | Regeneron Pharmaceuticals Inc                            | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |     34973 | NS      | $26525971.31  | 1.60%             |  |  |  | No            |                  1 | On Loan: No      |
| Laboratory Corp of America Hol                           | Laboratory Corp of America Holdings                      | CUSIP: 50540R409<br>LEI: OZ7UA8IXAIFILY2VZH07 | Long             | EC               | CORP              | US        |    142320 | NS      | $35881718.40  | 2.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Encompass Health Corp                                    | Encompass Health Corp                                    | CUSIP: 29261A100<br>LEI: 549300FVRPM9DRQZRG64 | Long             | EC               | CORP              | US        |    210949 | NS      | $13173765.05  | 0.79%             |  |  |  | No            |                  1 | On Loan: No      |
| Amgen Inc                                                | Amgen Inc                                                | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |     48036 | NS      | $12124286.40  | 0.73%             |  |  |  | No            |                  1 | On Loan: No      |
| Dexcom Inc                                               | Dexcom Inc                                               | CUSIP: 252131107<br>LEI: 549300YSK3QDSFR5EU59 | Long             | EC               | CORP              | US        |    222833 | NS      | $23863185.97  | 1.44%             |  |  |  | No            |                  1 | On Loan: No      |
| Repligen Corp                                            | Repligen Corp                                            | CUSIP: 759916109<br>LEI: 54930006QJ0T5AUO1E71 | Long             | EC               | CORP              | US        |     37260 | NS      | $6904278.00   | 0.42%             |  |  |  | No            |                  1 | On Loan: No      |
| Insulet Corp                                             | Insulet Corp                                             | CUSIP: 45784P101<br>LEI: 549300TZTYD2PYN92D43 | Long             | EC               | CORP              | US        |    113842 | NS      | $32709083.44  | 1.97%             |  |  |  | No            |                  1 | On Loan: No      |
| HCA Healthcare Inc                                       | HCA Healthcare Inc                                       | CUSIP: 40412C101<br>LEI: 529900PH4ZGUH2MNEU89 | Long             | EC               | CORP              | US        |    139663 | NS      | $35623841.41  | 2.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Gilead Sciences Inc                                      | Gilead Sciences Inc                                      | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |     73480 | NS      | $6167911.20   | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Bio-Techne Corp                                          | Bio-Techne Corp                                          | CUSIP: 09073M104<br>LEI: 54930073RLKQ51TILZ35 | Long             | EC               | CORP              | US        |     76114 | NS      | $6063241.24   | 0.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Incyte Corp                                              | Incyte Corp                                              | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |    314160 | NS      | $26747582.40  | 1.61%             |  |  |  | No            |                  1 | On Loan: No      |
| Amedisys Inc                                             | Amedisys Inc                                             | CUSIP: 023436108<br>LEI: 5299001RBS9GK9STN379 | Long             | EC               | CORP              | US        |    240697 | NS      | $23265772.02  | 1.40%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals Inc                               | Vertex Pharmaceuticals Inc                               | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |     69629 | NS      | $22497129.90  | 1.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Natera Inc                                               | Natera Inc                                               | CUSIP: 632307104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    157045 | NS      | $6741941.85   | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Sarepta Therapeutics Inc                                 | Sarepta Therapeutics Inc                                 | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |    258632 | NS      | $32321241.04  | 1.94%             |  |  |  | No            |                  1 | On Loan: No      |
| Thermo Fisher Scientific Inc                             | Thermo Fisher Scientific Inc                             | CUSIP: 883556102<br>LEI: HCHV7422L5HDJZCRFL38 | Long             | EC               | CORP              | US        |     11457 | NS      | $6534270.81   | 0.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Eli Lilly & Co                                           | Eli Lilly & Co                                           | CUSIP: 532457108<br>LEI: FRDRIPF3EKNDJ2CQJL29 | Long             | EC               | CORP              | US        |     34490 | NS      | $11869733.50  | 0.71%             |  |  |  | No            |                  1 | On Loan: No      |
| Medtronic PLC                                            | Medtronic PLC                                            | CUSIP: 000000000<br>LEI: 549300GX3ZBSQWUXY261 | Long             | EC               | CORP              | IE        |    258723 | NS      | $21652527.87  | 1.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Bruker Corp                                              | Bruker Corp                                              | CUSIP: 116794108<br>LEI: LEBZ6VLQ6I8XB1NHVY15 | Long             | EC               | CORP              | US        |    184592 | NS      | $12943591.04  | 0.78%             |  |  |  | No            |                  1 | On Loan: No      |
| Goldman Sachs Financial Square Treasury Obligations Fund | Goldman Sachs Financial Square Treasury Obligations Fund | CUSIP: 38141W323<br>LEI: 549300C0TCI4VJPGCS21 | Long             | STIV             | RF                | US        |   5332220 | NS      | $5332219.82   | 0.32%             |  |  |  | No            |                  1 | On Loan: No      |
| Envista Holdings Corp                                    | Envista Holdings Corp                                    | CUSIP: 29415F104<br>LEI: 549300BX623VURJZ5269 | Long             | EC               | CORP              | US        |    597209 | NS      | $23285178.91  | 1.40%             |  |  |  | No            |                  1 | On Loan: No      |
| QIAGEN NV                                                | QIAGEN NV                                                | CUSIP: 000000000<br>LEI: 54930036WK3GMCN17Z57 | Long             | EC               | CORP              | NL        |    403206 | NS      | $19757094.00  | 1.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Align Technology Inc                                     | Align Technology Inc                                     | CUSIP: 016255101<br>LEI: 549300N5YSE0U3LCP840 | Long             | EC               | CORP              | US        |     29911 | NS      | $8067894.03   | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals Inc                              | Alnylam Pharmaceuticals Inc                              | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |    141017 | NS      | $31926248.80  | 1.92%             |  |  |  | No            |                  1 | On Loan: No      |
| Charles River Laboratories Int                           | Charles River Laboratories International Inc             | CUSIP: 159864107<br>LEI: 549300BSQ0R4UZ5KX287 | Long             | EC               | CORP              | US        |     57904 | NS      | $14085148.00  | 0.85%             |  |  |  | No            |                  1 | On Loan: No      |
| Avantor Inc                                              | Avantor Inc                                              | CUSIP: 05352A100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    953435 | NS      | $22787096.50  | 1.37%             |  |  |  | No            |                  1 | On Loan: No      |
| IQVIA Holdings Inc                                       | IQVIA Holdings Inc                                       | CUSIP: 46266C105<br>LEI: 549300W3R20NM4KQPH86 | Long             | EC               | CORP              | US        |     30789 | NS      | $7063304.49   | 0.42%             |  |  |  | No            |                  1 | On Loan: No      |
| Teleflex Inc                                             | Teleflex Inc                                             | CUSIP: 879369106<br>LEI: UUL85LWXB4NGSWWXIQ25 | Long             | EC               | CORP              | US        |     50543 | NS      | $12303177.06  | 0.74%             |  |  |  | No            |                  1 | On Loan: No      |
| Organon & Co                                             | Organon & Co                                             | CUSIP: 68622V106<br>LEI: 549300AMCKY57OK2CO56 | Long             | EC               | CORP              | US        |    719939 | NS      | $21691762.07  | 1.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Chemed Corp                                              | Chemed Corp                                              | CUSIP: 16359R103<br>LEI: 54930020031IDJT2IM79 | Long             | EC               | CORP              | US        |     24721 | NS      | $12487565.94  | 0.75%             |  |  |  | No            |                  1 | On Loan: No      |
| Catalent Inc                                             | Catalent Inc                                             | CUSIP: 148806102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    560620 | NS      | $30021201.00  | 1.81%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences Inc                               | Neurocrine Biosciences Inc                               | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |    211267 | NS      | $23435848.31  | 1.41%             |  |  |  | No            |                  1 | On Loan: No      |
| IDEXX Laboratories Inc                                   | IDEXX Laboratories Inc                                   | CUSIP: 45168D104<br>LEI: OGMTXK0LUU1HKV2P0J84 | Long             | EC               | CORP              | US        |     15462 | NS      | $7429491.00   | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Horizon Therapeutics Plc                                 | Horizon Therapeutics Plc                                 | CUSIP: 000000000<br>LEI: 529900P0GSQ79OOZEV53 | Long             | EC               | CORP              | US        |    294493 | NS      | $32311771.96  | 1.94%             |  |  |  | No            |                  1 | On Loan: No      |
| Cigna Corp                                               | Cigna Corp                                               | CUSIP: 125523100<br>LEI: 549300VIWYMSIGT1U456 | Long             | EC               | CORP              | US        |    101146 | NS      | $32029903.82  | 1.93%             |  |  |  | No            |                  1 | On Loan: No      |
| Zimmer Biomet Holdings Inc                               | Zimmer Biomet Holdings Inc                               | CUSIP: 98956P102<br>LEI: 2P2YLDVPES3BXQ1FRB91 | Long             | EC               | CORP              | US        |     49476 | NS      | $6300273.84   | 0.38%             |  |  |  | No            |                  1 | On Loan: No      |
| Syneos Health Inc                                        | Syneos Health Inc                                        | CUSIP: 87166B102<br>LEI: 549300F1ZGKDS8P6GU13 | Long             | EC               | CORP              | US        |    913667 | NS      | $32818918.64  | 1.97%             |  |  |  | No            |                  1 | On Loan: No      |
| Baxter International Inc                                 | Baxter International Inc                                 | CUSIP: 071813109<br>LEI: J5OIVXX3P24RJRW5CK77 | Long             | EC               | CORP              | US        |    123766 | NS      | $5654868.54   | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Perrigo Co PLC                                           | Perrigo Co PLC                                           | CUSIP: 000000000<br>LEI: 549300IFOQS6R1QLY196 | Long             | EC               | CORP              | IE        |    370099 | NS      | $13849104.58  | 0.83%             |  |  |  | No            |                  1 | On Loan: No      |
| Elevance Health Inc                                      | Elevance Health Inc                                      | CUSIP: 036752103<br>LEI: 8MYN82XMYQH89CTMTH67 | Long             | EC               | CORP              | US        |     65334 | NS      | $32666346.66  | 1.96%             |  |  |  | No            |                  1 | On Loan: No      |
| Masimo Corp                                              | Masimo Corp                                              | CUSIP: 574795100<br>LEI: 549300Q4A8JK0PIYCU29 | Long             | EC               | CORP              | US        |     42638 | NS      | $7251871.04   | 0.44%             |  |  |  | No            |                  1 | On Loan: No      |
| Enovis Corp                                              | Enovis Corp                                              | CUSIP: 194014502<br>LEI: 635400OP2DYYYMOIYL17 | Long             | EC               | CORP              | US        |    471479 | NS      | $29679603.05  | 1.79%             |  |  |  | No            |                  1 | On Loan: No      |
| Universal Health Services Inc                            | Universal Health Services Inc                            | CUSIP: 913903100<br>LEI: 549300YGMGQDO0NMJD09 | Long             | EC               | CORP              | US        |    237871 | NS      | $35254860.91  | 2.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Hologic Inc                                              | Hologic Inc                                              | CUSIP: 436440101<br>LEI: 549300DYP6F5ZJL0LB74 | Long             | EC               | CORP              | US        |    337304 | NS      | $27446426.48  | 1.65%             |  |  |  | No            |                  1 | On Loan: No      |
| Cooper Cos Inc/The                                       | Cooper Cos Inc/The                                       | CUSIP: 216648402<br>LEI: QJKMVPIGLH7530PCUE20 | Long             | EC               | CORP              | US        |     19075 | NS      | $6655839.75   | 0.40%             |  |  |  | No            |                  1 | On Loan: No      |
| ICU Medical Inc                                          | ICU Medical Inc                                          | CUSIP: 44930G107<br>LEI: 5493003NRW7LS2QZRH60 | Long             | EC               | CORP              | US        |     80119 | NS      | $15481394.37  | 0.93%             |  |  |  | No            |                  1 | On Loan: No      |
| Viatris Inc                                              | Viatris Inc                                              | CUSIP: 92556V106<br>LEI: 254900ZZTSW7NL773X71 | Long             | EC               | CORP              | US        |   3011077 | NS      | $36614696.32  | 2.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Johnson & Johnson                                        | Johnson & Johnson                                        | CUSIP: 478160104<br>LEI: 549300G0CFPGEF6X2043 | Long             | EC               | CORP              | US        |     71421 | NS      | $11671619.82  | 0.70%             |  |  |  | No            |                  1 | On Loan: No      |
| Molina Healthcare Inc                                    | Molina Healthcare Inc                                    | CUSIP: 60855R100<br>LEI: 549300NQQCEQ46YHZ591 | Long             | EC               | CORP              | US        |    101488 | NS      | $31647003.04  | 1.90%             |  |  |  | No            |                  1 | On Loan: No      |
| Abbott Laboratories                                      | Abbott Laboratories                                      | CUSIP: 002824100<br>LEI: HQD377W2YR662HK5JX27 | Long             | EC               | CORP              | US        |    114915 | NS      | $12703853.25  | 0.76%             |  |  |  | No            |                  1 | On Loan: No      |
| Elanco Animal Health Inc                                 | Elanco Animal Health Inc                                 | CUSIP: 28414H103<br>LEI: 549300SHPNDCE059M934 | Long             | EC               | CORP              | US        |   1645494 | NS      | $22592632.62  | 1.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Exact Sciences Corp                                      | Exact Sciences Corp                                      | CUSIP: 30063P105<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |    509666 | NS      | $34412648.32  | 2.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Integra LifeSciences Holdings                            | Integra LifeSciences Holdings Corp                       | CUSIP: 457985208<br>LEI: WB7IJCYY8YFTENS4O147 | Long             | EC               | CORP              | US        |    225017 | NS      | $12893474.10  | 0.78%             |  |  |  | No            |                  1 | On Loan: No      |
| AbbVie Inc                                               | AbbVie Inc                                               | CUSIP: 00287Y109<br>LEI: FR5LCKFTG8054YNNRU85 | Long             | EC               | CORP              | US        |    124420 | NS      | $18383055.00  | 1.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Moderna Inc                                              | Moderna Inc                                              | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |    186576 | NS      | $32848570.56  | 1.98%             |  |  |  | No            |                  1 | On Loan: No      |
| Globus Medical Inc                                       | Globus Medical Inc                                       | CUSIP: 379577208<br>LEI: 5299003M2P4CIK0RF205 | Long             | EC               | CORP              | US        |    339755 | NS      | $25651502.50  | 1.54%             |  |  |  | No            |                  1 | On Loan: No      |
| Sotera Health Co                                         | Sotera Health Co                                         | CUSIP: 83601L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    757305 | NS      | $13055938.20  | 0.79%             |  |  |  | No            |                  1 | On Loan: No      |
| Certara Inc                                              | Certara Inc                                              | CUSIP: 15687V109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    392555 | NS      | $7615567.00   | 0.46%             |  |  |  | No            |                  1 | On Loan: No      |
| QuidelOrtho Corp                                         | QuidelOrtho Corp                                         | CUSIP: 219798105<br>LEI: 549300YU8CMO9HF53113 | Long             | EC               | CORP              | US        |    391193 | NS      | $33490032.73  | 2.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Exelixis Inc                                             | Exelixis Inc                                             | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |   1573163 | NS      | $27719132.06  | 1.67%             |  |  |  | No            |                  1 | On Loan: No      |
| Ionis Pharmaceuticals Inc                                | Ionis Pharmaceuticals Inc                                | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |    334045 | NS      | $13318374.15  | 0.80%             |  |  |  | No            |                  1 | On Loan: No      |
| Henry Schein Inc                                         | Henry Schein Inc                                         | CUSIP: 806407102<br>LEI: VGO3WGL8H45T73F4RR92 | Long             | EC               | CORP              | US        |    315931 | NS      | $27217455.65  | 1.64%             |  |  |  | No            |                  1 | On Loan: No      |
| Tenet Healthcare Corp                                    | Tenet Healthcare Corp                                    | CUSIP: 88033G407<br>LEI: 0W9AIBT6U6ADJ2I8HK17 | Long             | EC               | CORP              | US        |    412131 | NS      | $22605385.35  | 1.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Azenta Inc                                               | Azenta Inc                                               | CUSIP: 114340102<br>LEI: 35ZN6X1ANPH25YN32Y17 | Long             | EC               | CORP              | US        |    108353 | NS      | $6056932.70   | 0.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Merck & Co Inc                                           | Merck & Co Inc                                           | CUSIP: 58933Y105<br>LEI: 4YV9Y5M8S0BRK1RP0397 | Long             | EC               | CORP              | US        |    302054 | NS      | $32443620.14  | 1.95%             |  |  |  | No            |                  1 | On Loan: No      |
| Agilent Technologies Inc                                 | Agilent Technologies Inc                                 | CUSIP: 00846U101<br>LEI: QUIX8Y7A2WP0XRMW7G29 | Long             | EC               | CORP              | US        |    168619 | NS      | $25643577.52  | 1.54%             |  |  |  | No            |                  1 | On Loan: No      |
| Quest Diagnostics Inc                                    | Quest Diagnostics Inc                                    | CUSIP: 74834L100<br>LEI: 8MCWUBXQ0WE04KMXBX50 | Long             | EC               | CORP              | US        |    161298 | NS      | $23949527.04  | 1.44%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2023-03-22

**Name of Applicant:** First Trust Exchange-Traded AlphaDEX Fund

**Signature:** Donald P. Swade

**Name of Signer:** Donald P. Swade

**Title:** Treasurer, Chief Financial Officer and Chief Accounting Officer