# EDGAR Filing Document

**Accession Number:** 0001808158
**File Stem:** 0001193125-23-003571
**Filing Date:** 2023-1
**Character Count:** 50183
**Document Hash:** e71faba6037ee91c701f5fcd61db32b4
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-23-003571.hdr.sgml**: 20230106

**ACCESSION NUMBER**: 0001193125-23-003571

**CONFORMED SUBMISSION TYPE**: SC 13D/A

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20230106

**DATE AS OF CHANGE**: 20230106

**GROUP MEMBERS**: VERSANT AFFILIATES FUND V, L.P.

**GROUP MEMBERS**: VERSANT OPHTHALMIC AFFILIATES FUND I, L.P.

**GROUP MEMBERS**: VERSANT VANTAGE I GP, L.P.

**GROUP MEMBERS**: VERSANT VANTAGE I GP-GP, LLC

**GROUP MEMBERS**: VERSANT VANTAGE I, L.P.

**GROUP MEMBERS**: VERSANT VENTURE CAPITAL V (CANADA) LP

**GROUP MEMBERS**: VERSANT VENTURE CAPITAL VI, L.P.

**GROUP MEMBERS**: VERSANT VENTURES V (CANADA), L.P.

**GROUP MEMBERS**: VERSANT VENTURES V GP-GP (CANADA), INC.

**GROUP MEMBERS**: VERSANT VENTURES V, LLC

**GROUP MEMBERS**: VERSANT VENTURES VI GP, L.P.

**GROUP MEMBERS**: VERSANT VENTURES VI GP-GP, LLC

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Repare Therapeutics Inc.
- **CENTRAL INDEX KEY:** 0001808158
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** Z4
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13D/A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-91542
- **FILM NUMBER:** 23515331

**BUSINESS ADDRESS:**
- **STREET 1:** 7210 FREDERICK-BANTING, SUITE 100
- **CITY:** ST-LAURENT
- **STATE:** A8
- **ZIP:** H4S 2A1
- **BUSINESS PHONE:** (857) 412-7018

**MAIL ADDRESS:**
- **STREET 1:** 7210 FREDERICK-BANTING, SUITE 100
- **CITY:** ST-LAURENT
- **STATE:** A8
- **ZIP:** H4S 2A1
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Versant Venture Capital V, L.P.
- **CENTRAL INDEX KEY:** 0001589097
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13D/A

**BUSINESS ADDRESS:**
- **STREET 1:** ONE SANSOME STREET
- **STREET 2:** SUITE 3630
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94104
- **BUSINESS PHONE:** 650-233-7877

**MAIL ADDRESS:**
- **STREET 1:** ONE SANSOME STREET
- **STREET 2:** SUITE 3630
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94104

------

------

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**WASHINGTON, D.C. 20549** 

------

**SCHEDULE 13D** 

**(Rule 13d-102)**

**INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT** 

**TO RULE 13d-l(a) AND AMENDMENTS THERETO FILED PURSUANT** 

**TO RULE 13d-2(a)**

**(Amendment No. 5)\*** 

------

## REPARE THERAPEUTICS INC.
**(Name of Issuer)** 

**Common Shares** 

**(Title of Class of Securities)** 

**760273102** 

**(CUSIP Number)** 

**Versant Venture Capital V, L.P.** 

**Max Eisenberg** 

**One Sansome Street, Suite 3630** 

**San Francisco, CA 94104** 

**415-801-8100**

**(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)** 

**December 29, 2022** 

**(Date of Event Which Requires Filing of this Statement)** 

------

If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. ☐

\* The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act.

------

CUSIP No. 760273102 13D

1. &nbsp;&nbsp;&nbsp;&nbsp; Name of Reporting Persons &nbsp;&nbsp;&nbsp;&nbsp; Versant Venture Capital V, L.P.

2. &nbsp;&nbsp;&nbsp;&nbsp; Check the Appropriate Box
if a Member of a Group (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; (a) ☐ (b) ☒(1)

3. &nbsp;&nbsp;&nbsp;&nbsp; SEC USE ONLY

4. &nbsp;&nbsp;&nbsp;&nbsp; Source of Funds (see
instructions) &nbsp;&nbsp;&nbsp;&nbsp; WC

5. &nbsp;&nbsp;&nbsp;&nbsp; Check if Disclosure of
Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e) &nbsp;&nbsp;&nbsp;&nbsp; ☐

6. &nbsp;&nbsp;&nbsp;&nbsp; Citizenship or Place of
Organization &nbsp;&nbsp;&nbsp;&nbsp; Delaware, United
States

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;7. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;563,403 Common Shares (2) |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;8. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;9. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;563,403 Common Shares (2) |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 10. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |

---

11. &nbsp;&nbsp;&nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person &nbsp;&nbsp;&nbsp;&nbsp; 563,403 Common Shares (2)

12. &nbsp;&nbsp;&nbsp;&nbsp; Check if the Aggregate
Amount in Row (11) Excludes Certain Shares (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; ☐

13. &nbsp;&nbsp;&nbsp;&nbsp; Percent of Class
Represented by Amount in Row 11 &nbsp;&nbsp;&nbsp;&nbsp; 1.3% (3)

14. &nbsp;&nbsp;&nbsp;&nbsp; Type of Reporting Person
(see instructions) &nbsp;&nbsp;&nbsp;&nbsp; PN

(1) This Schedule 13D is filed by Versant Venture Capital V, L.P. ("VVC V"), Versant Affiliates Fund V,
L.P. ("VAF V"), Versant Ophthalmic Affiliates Fund I, L.P. ("VOA"), Versant Ventures V, LLC ("VV V"), Versant Venture Capital VI, L.P. ("Versant VI"), Versant Ventures VI GP, L.P. ("GP VI"), Versant
Ventures VI GP-GP, LLC ("LLC VI"), Versant Vantage I, L.P. ("Vantage LP"), Versant Vantage I GP, L.P. ("Vantage GP"), Versant Vantage I GP-GP, LLC ("Vantage LLC"), Versant Ventures V GP-GP (Canada), Inc. ("VV V CAN GP"), Versant Ventures V (Canada), L.P. ("VV V CAN"),
Versant Venture Capital V (Canada) LP ("VVC CAN" and, with VV V CAN GP, Vantage LLC, VVC V, VAF V, VOA, VV V CAN, VV V, Versant VI, GP VI, LLC VI, Vantage LP and Vantage GP, collectively, the "Reporting Persons"). VV V is the
sole general partner of VVC V, VAF V and VOA. LLC VI is the general partner of GP VI, which is the general partner of Versant VI. Each of LLC VI and GP VI share voting and dispositive power over the shares held by Versant VI. Vantage LLC is the
general partner of Vantage GP, which is the general partner of Vantage LP. Each of Vantage LLC and Vantage GP share voting and dispositive power over the shares held by Vantage LP. VV V CAN GP is the sole general partner of VV V CAN, and VV V CAN is
the sole general partner of VVC CAN. Each of VV V CAN GP and VV V CAN share voting and dispositive power over the shares held by VVC CAN. The Reporting Persons expressly disclaim status as a "group" for purposes of this Schedule 13D.

(2) These shares are held by VVC V. VV V is the sole general partner of VVC V and may be deemed to have voting and
dispositive power over the securities held by VVC V and as a result may be deemed to have beneficial ownership over such securities.

(3) This calculation is based upon 41,961,510 shares of the Issuer's Common Shares outstanding as of
October 31, 2022, as reported in the Issuer's quarterly report on Form 10-Q for the quarter ended September 30, 2022, filed with the United States Securities and Exchange Commission on
November 9, 2022 (the "Form 10-Q").

------

CUSIP No. 760273102 13D

1. &nbsp;&nbsp;&nbsp;&nbsp; Name of Reporting Persons &nbsp;&nbsp;&nbsp;&nbsp; Versant Affiliates Fund V, L.P.

2. &nbsp;&nbsp;&nbsp;&nbsp; Check the Appropriate Box
if a Member of a Group (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; (a) ☐ (b) ☒(1)

3. &nbsp;&nbsp;&nbsp;&nbsp; SEC USE ONLY

4. &nbsp;&nbsp;&nbsp;&nbsp; Source of Funds (see
instructions) &nbsp;&nbsp;&nbsp;&nbsp; WC

5. &nbsp;&nbsp;&nbsp;&nbsp; Check if Disclosure of
Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e) &nbsp;&nbsp;&nbsp;&nbsp; ☐

6. &nbsp;&nbsp;&nbsp;&nbsp; Citizenship or Place of
Organization &nbsp;&nbsp;&nbsp;&nbsp; Delaware, United
States

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;7. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;16,949 Common Shares (2) |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;8. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;9. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;16,949 Common Shares (2) |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 10. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |

---

11. &nbsp;&nbsp;&nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person &nbsp;&nbsp;&nbsp;&nbsp; 16,949 Common Shares (2)

12. &nbsp;&nbsp;&nbsp;&nbsp; Check if the Aggregate
Amount in Row (11) Excludes Certain Shares (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; ☐

13. &nbsp;&nbsp;&nbsp;&nbsp; Percent of Class
Represented by Amount in Row 11 &nbsp;&nbsp;&nbsp;&nbsp; 0.0% (3)

14. &nbsp;&nbsp;&nbsp;&nbsp; Type of Reporting Person
(see instructions) &nbsp;&nbsp;&nbsp;&nbsp; PN

(1) This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a
"group" for purposes of this Schedule 13D.

(2) These shares are held by VAF V. VV V is the sole general partner of VAF V and may be deemed to have voting and
dispositive power over the securities held by VAF V and as a result may be deemed to have beneficial ownership over such securities.

(3) This calculation is based upon 41,961,510 shares of the Issuer's Common Shares outstanding as of
October 31, 2022, as reported in the Form 10-Q.

------

CUSIP No. 760273102 13D

1. &nbsp;&nbsp;&nbsp;&nbsp; Name of Reporting Persons &nbsp;&nbsp;&nbsp;&nbsp; Versant Ophthalmic Affiliates Fund I, L.P.

2. &nbsp;&nbsp;&nbsp;&nbsp; Check the Appropriate Box
if a Member of a Group (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; (a) ☐ (b) ☒(1)

3. &nbsp;&nbsp;&nbsp;&nbsp; SEC USE ONLY

4. &nbsp;&nbsp;&nbsp;&nbsp; Source of Funds (see
instructions) &nbsp;&nbsp;&nbsp;&nbsp; WC

5. &nbsp;&nbsp;&nbsp;&nbsp; Check if Disclosure of
Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e) &nbsp;&nbsp;&nbsp;&nbsp; ☐

6. &nbsp;&nbsp;&nbsp;&nbsp; Citizenship or Place of
Organization &nbsp;&nbsp;&nbsp;&nbsp; Delaware, United
States

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;7. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;18,761 Common Shares (2) |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;8. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;9. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;18,761 Common Shares (2) |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 10. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |

---

11. &nbsp;&nbsp;&nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person &nbsp;&nbsp;&nbsp;&nbsp; 18,761 Common Shares (2)

12. &nbsp;&nbsp;&nbsp;&nbsp; Check if the Aggregate
Amount in Row (11) Excludes Certain Shares (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; ☐

13. &nbsp;&nbsp;&nbsp;&nbsp; Percent of Class
Represented by Amount in Row 11 &nbsp;&nbsp;&nbsp;&nbsp; 0.0% (3)

14. &nbsp;&nbsp;&nbsp;&nbsp; Type of Reporting Person
(see instructions) &nbsp;&nbsp;&nbsp;&nbsp; PN

(1) This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a
"group" for purposes of this Schedule 13D.

(2) These shares are held by VOA. VV V is the sole general partner of VOA and may be deemed to have voting and
dispositive power over the securities held by VOA and as a result may be deemed to have beneficial ownership over such securities.

(3) This calculation is based upon 41,961,510 shares of the Issuer's Common Shares outstanding as of
October 31, 2022, as reported in the Form 10-Q.

------

CUSIP No. 760273102 13D

1. &nbsp;&nbsp;&nbsp;&nbsp; Name of Reporting Persons &nbsp;&nbsp;&nbsp;&nbsp; Versant Ventures V, LLC

2. &nbsp;&nbsp;&nbsp;&nbsp; Check the Appropriate Box
if a Member of a Group (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; (a) ☐ (b) ☒(1)

3. &nbsp;&nbsp;&nbsp;&nbsp; SEC USE ONLY

4. &nbsp;&nbsp;&nbsp;&nbsp; Source of Funds (see
instructions) &nbsp;&nbsp;&nbsp;&nbsp; AF

5. &nbsp;&nbsp;&nbsp;&nbsp; Check if Disclosure of
Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e) &nbsp;&nbsp;&nbsp;&nbsp; ☐

6. &nbsp;&nbsp;&nbsp;&nbsp; Citizenship or Place of
Organization &nbsp;&nbsp;&nbsp;&nbsp; Delaware

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;7. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;8. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;599,113 Common Shares (2) |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;9. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 10. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;599,113 Common Shares (2) |

---

11. &nbsp;&nbsp;&nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person &nbsp;&nbsp;&nbsp;&nbsp; 599,113 Common Shares (2)

12. &nbsp;&nbsp;&nbsp;&nbsp; Check if the Aggregate
Amount in Row (11) Excludes Certain Shares (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; ☐

13. &nbsp;&nbsp;&nbsp;&nbsp; Percent of Class
Represented by Amount in Row 11 &nbsp;&nbsp;&nbsp;&nbsp; 1.4% (3)

14. &nbsp;&nbsp;&nbsp;&nbsp; Type of Reporting Person
(see instructions) &nbsp;&nbsp;&nbsp;&nbsp; OO

(1) This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a
"group" for purposes of this Schedule 13D.

(2) Includes (i) 563,403 shares are held by VVC V, (ii) 16,949 shares held by VAF V, and (iii) 18,761 shares held
by VOA. VV V is the sole general partner of VVC V, VAF V and VOA and may be deemed to have voting and dispositive power over the securities held by VVC V, VAF V and VOA.

(3) This calculation is based upon 41,961,510 shares of the Issuer's Common Shares outstanding as of
October 31, 2022, as reported in the Form 10-Q.

------

CUSIP No. 760273102 13D

1. &nbsp;&nbsp;&nbsp;&nbsp; Name of Reporting Persons &nbsp;&nbsp;&nbsp;&nbsp; Versant Venture Capital V (Canada) LP

2. &nbsp;&nbsp;&nbsp;&nbsp; Check the Appropriate Box
if a Member of a Group (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; (a) ☐ (b) ☒(1)

3. &nbsp;&nbsp;&nbsp;&nbsp; SEC USE ONLY

4. &nbsp;&nbsp;&nbsp;&nbsp; Source of Funds (see
instructions) &nbsp;&nbsp;&nbsp;&nbsp; WC

5. &nbsp;&nbsp;&nbsp;&nbsp; Check if Disclosure of
Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e) &nbsp;&nbsp;&nbsp;&nbsp; ☐

6. &nbsp;&nbsp;&nbsp;&nbsp; Citizenship or Place of
Organization &nbsp;&nbsp;&nbsp;&nbsp; Ontario,
Canada

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;7. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;42,877 Common Shares (2) |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;8. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;9. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;42,877 Common Shares (2) |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 10. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |

---

11. &nbsp;&nbsp;&nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person &nbsp;&nbsp;&nbsp;&nbsp; 42,877 Common Shares (2)

12. &nbsp;&nbsp;&nbsp;&nbsp; Check if the Aggregate
Amount in Row (11) Excludes Certain Shares (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; ☐

13. &nbsp;&nbsp;&nbsp;&nbsp; Percent of Class
Represented by Amount in Row 11 &nbsp;&nbsp;&nbsp;&nbsp; 0.1% (3)

14. &nbsp;&nbsp;&nbsp;&nbsp; Type of Reporting Person
(see instructions) &nbsp;&nbsp;&nbsp;&nbsp; PN

(1) This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a
"group" for purposes of this Schedule 13D.

(2) These shares are held by VVC CAN. VV V CAN GP is the sole general partner of VV V CAN, and VV V CAN is the sole
general partner of VVC CAN. Each of VV V CAN GP and VV V CAN share voting and dispositive power over the shares held by VVC CAN and as a result may be deemed to have beneficial ownership over such securities.

(3) This calculation is based upon 41,961,510 shares of the Issuer's Common Shares outstanding as of
October 31, 2022, as reported in the Form 10-Q.

------

CUSIP No. 760273102 13D

1. &nbsp;&nbsp;&nbsp;&nbsp; Name of Reporting Persons &nbsp;&nbsp;&nbsp;&nbsp; Versant Ventures V GP-GP (Canada), Inc.

2. &nbsp;&nbsp;&nbsp;&nbsp; Check the Appropriate Box
if a Member of a Group (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; (a) ☐ (b) ☒(1)

3. &nbsp;&nbsp;&nbsp;&nbsp; SEC USE ONLY

4. &nbsp;&nbsp;&nbsp;&nbsp; Source of Funds (see
instructions) &nbsp;&nbsp;&nbsp;&nbsp; AF

5. &nbsp;&nbsp;&nbsp;&nbsp; Check if Disclosure of
Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e) &nbsp;&nbsp;&nbsp;&nbsp; ☐

6. &nbsp;&nbsp;&nbsp;&nbsp; Citizenship or Place of
Organization &nbsp;&nbsp;&nbsp;&nbsp; Delaware

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;7. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;8. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;42,877 Common Shares (2) |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;9. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 10. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;42,877 Common Shares (2) |

---

11. &nbsp;&nbsp;&nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person &nbsp;&nbsp;&nbsp;&nbsp; 42,877 Common Shares (2)

12. &nbsp;&nbsp;&nbsp;&nbsp; Check if the Aggregate
Amount in Row (11) Excludes Certain Shares (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; ☐

13. &nbsp;&nbsp;&nbsp;&nbsp; Percent of Class
Represented by Amount in Row 11 &nbsp;&nbsp;&nbsp;&nbsp; 0.1% (3)

14. &nbsp;&nbsp;&nbsp;&nbsp; Type of Reporting Person
(see instructions) &nbsp;&nbsp;&nbsp;&nbsp; CO

(1) This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a
"group" for purposes of this Schedule 13D.

(2) These shares are held by VVC CAN. VV V CAN GP is the sole general partner of VV V CAN, and VV V CAN is the sole
general partner of VVC CAN. Each of VV V CAN GP and VV V CAN share voting and dispositive power over the shares held by VVC CAN and as a result may be deemed to have beneficial ownership over such securities.

(3) This calculation is based upon 41,961,510 shares of the Issuer's Common Shares outstanding as of
October 31, 2022, as reported in the Form 10-Q.

------

CUSIP No. 760273102 13D

1. &nbsp;&nbsp;&nbsp;&nbsp; Name of Reporting Persons &nbsp;&nbsp;&nbsp;&nbsp; Versant Ventures V (Canada), L.P.

2. &nbsp;&nbsp;&nbsp;&nbsp; Check the Appropriate Box
if a Member of a Group (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; (a) ☐ (b) ☒(1)

3. &nbsp;&nbsp;&nbsp;&nbsp; SEC USE ONLY

4. &nbsp;&nbsp;&nbsp;&nbsp; Source of Funds (see
instructions) &nbsp;&nbsp;&nbsp;&nbsp; AF

5. &nbsp;&nbsp;&nbsp;&nbsp; Check if Disclosure of
Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e) &nbsp;&nbsp;&nbsp;&nbsp; ☐

6. &nbsp;&nbsp;&nbsp;&nbsp; Citizenship or Place of
Organization &nbsp;&nbsp;&nbsp;&nbsp; Delaware

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;7. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;8. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;42,877 Common Shares (2) |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;9. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 10. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;42,877 Common Shares (2) |

---

11. &nbsp;&nbsp;&nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person &nbsp;&nbsp;&nbsp;&nbsp; 42,877 Common Shares (2)

12. &nbsp;&nbsp;&nbsp;&nbsp; Check if the Aggregate
Amount in Row (11) Excludes Certain Shares (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; ☐

13. &nbsp;&nbsp;&nbsp;&nbsp; Percent of Class
Represented by Amount in Row 11 &nbsp;&nbsp;&nbsp;&nbsp; 0.1% (3)

14. &nbsp;&nbsp;&nbsp;&nbsp; Type of Reporting Person
(see instructions) &nbsp;&nbsp;&nbsp;&nbsp; PN

(1) This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a
"group" for purposes of this Schedule 13D.

(2) These shares are held by VVC CAN. VV V CAN GP is the sole general partner of VV V CAN, and VV V CAN is the sole
general partner of VVC CAN. Each of VV V CAN GP and VV V CAN share voting and dispositive power over the shares held by VVC CAN and as a result may be deemed to have beneficial ownership over such securities.

(3) This calculation is based upon 41,961,510 shares of the Issuer's Common Shares outstanding as of
October 31, 2022, as reported in the Form 10-Q.

------

CUSIP No. 760273102 13D

---

| | | | |
|:---|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; 1. | &nbsp;&nbsp;&nbsp;&nbsp;Name of Reporting Persons<br>&nbsp;&nbsp;&nbsp;&nbsp;Versant Venture Capital VI, L.P. | &nbsp;&nbsp;&nbsp;&nbsp;Name of Reporting Persons<br>&nbsp;&nbsp;&nbsp;&nbsp;Versant Venture Capital VI, L.P. | &nbsp;&nbsp;&nbsp;&nbsp;Name of Reporting Persons<br>&nbsp;&nbsp;&nbsp;&nbsp;Versant Venture Capital VI, L.P. |
| &nbsp;&nbsp;&nbsp; 2. | &nbsp;&nbsp;&nbsp;&nbsp;Check the Appropriate Box if a Member of a Group (see instructions)<br> &nbsp;&nbsp;&nbsp;&nbsp;(a) ☐ (b) ☒(1) | &nbsp;&nbsp;&nbsp;&nbsp;Check the Appropriate Box if a Member of a Group (see instructions)<br> &nbsp;&nbsp;&nbsp;&nbsp;(a) ☐ (b) ☒(1) | &nbsp;&nbsp;&nbsp;&nbsp;Check the Appropriate Box if a Member of a Group (see instructions)<br> &nbsp;&nbsp;&nbsp;&nbsp;(a) ☐ (b) ☒(1) |
| &nbsp;&nbsp;&nbsp; 3. | &nbsp;&nbsp;&nbsp;&nbsp;SEC USE ONLY | &nbsp;&nbsp;&nbsp;&nbsp;SEC USE ONLY | &nbsp;&nbsp;&nbsp;&nbsp;SEC USE ONLY |
| &nbsp;&nbsp;&nbsp; 4. | &nbsp;&nbsp;&nbsp;&nbsp;Source of Funds (see instructions)<br>&nbsp;&nbsp;&nbsp;&nbsp;WC | &nbsp;&nbsp;&nbsp;&nbsp;Source of Funds (see instructions)<br>&nbsp;&nbsp;&nbsp;&nbsp;WC | &nbsp;&nbsp;&nbsp;&nbsp;Source of Funds (see instructions)<br>&nbsp;&nbsp;&nbsp;&nbsp;WC |
| &nbsp;&nbsp;&nbsp; 5. | &nbsp;&nbsp;&nbsp;&nbsp;Check if Disclosure of Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e)<br>&nbsp;&nbsp;&nbsp;&nbsp;☐ | &nbsp;&nbsp;&nbsp;&nbsp;Check if Disclosure of Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e)<br>&nbsp;&nbsp;&nbsp;&nbsp;☐ | &nbsp;&nbsp;&nbsp;&nbsp;Check if Disclosure of Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e)<br>&nbsp;&nbsp;&nbsp;&nbsp;☐ |
| &nbsp;&nbsp;&nbsp; 6. | &nbsp;&nbsp;&nbsp;&nbsp;Citizenship or Place of Organization<br>&nbsp;&nbsp;&nbsp;&nbsp;Delaware | &nbsp;&nbsp;&nbsp;&nbsp;Citizenship or Place of Organization<br>&nbsp;&nbsp;&nbsp;&nbsp;Delaware | &nbsp;&nbsp;&nbsp;&nbsp;Citizenship or Place of Organization<br>&nbsp;&nbsp;&nbsp;&nbsp;Delaware |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;7. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;2,094,451 Common Shares (2) |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;8. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;9. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;2,094,451 Common Shares (2) |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 10. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |
| &nbsp;&nbsp;&nbsp;11. | &nbsp;&nbsp;&nbsp;&nbsp;Aggregate Amount Beneficially Owned by Each Reporting Person<br>&nbsp;&nbsp;&nbsp;&nbsp;2,094,451 Common Shares (2) | &nbsp;&nbsp;&nbsp;&nbsp;Aggregate Amount Beneficially Owned by Each Reporting Person<br>&nbsp;&nbsp;&nbsp;&nbsp;2,094,451 Common Shares (2) | &nbsp;&nbsp;&nbsp;&nbsp;Aggregate Amount Beneficially Owned by Each Reporting Person<br>&nbsp;&nbsp;&nbsp;&nbsp;2,094,451 Common Shares (2) |
| &nbsp;&nbsp;&nbsp;12. | &nbsp;&nbsp;&nbsp;&nbsp;Check if the Aggregate Amount in Row (11) Excludes Certain Shares (see instructions)<br>&nbsp;&nbsp;&nbsp;&nbsp;☐ | &nbsp;&nbsp;&nbsp;&nbsp;Check if the Aggregate Amount in Row (11) Excludes Certain Shares (see instructions)<br>&nbsp;&nbsp;&nbsp;&nbsp;☐ | &nbsp;&nbsp;&nbsp;&nbsp;Check if the Aggregate Amount in Row (11) Excludes Certain Shares (see instructions)<br>&nbsp;&nbsp;&nbsp;&nbsp;☐ |
| &nbsp;&nbsp;&nbsp;13. | &nbsp;&nbsp;&nbsp;&nbsp;Percent of Class Represented by Amount in Row 11<br>&nbsp;&nbsp;&nbsp;&nbsp;5.0% (3) | &nbsp;&nbsp;&nbsp;&nbsp;Percent of Class Represented by Amount in Row 11<br>&nbsp;&nbsp;&nbsp;&nbsp;5.0% (3) | &nbsp;&nbsp;&nbsp;&nbsp;Percent of Class Represented by Amount in Row 11<br>&nbsp;&nbsp;&nbsp;&nbsp;5.0% (3) |
| &nbsp;&nbsp;&nbsp;14. | &nbsp;&nbsp;&nbsp;&nbsp;Type of Reporting Person (see instructions)<br>&nbsp;&nbsp;&nbsp;&nbsp;PN | &nbsp;&nbsp;&nbsp;&nbsp;Type of Reporting Person (see instructions)<br>&nbsp;&nbsp;&nbsp;&nbsp;PN | &nbsp;&nbsp;&nbsp;&nbsp;Type of Reporting Person (see instructions)<br>&nbsp;&nbsp;&nbsp;&nbsp;PN |

---

(1) This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a
"group" for purposes of this Schedule 13D.

(2) These shares are held by Versant VI. LLC VI is the general partner of GP VI, which is the general partner of
Versant VI. Each of LLC VI and GP VI share voting and dispositive power over the shares held by Versant VI and as a result may be deemed to have beneficial ownership over such securities.

(3) This calculation is based upon 41,961,510 shares of the Issuer's Common Shares outstanding as of
October 31, 2022, as reported in the Form 10-Q.

------

CUSIP No. 760273102 13D

1. &nbsp;&nbsp;&nbsp;&nbsp; Name of Reporting Persons &nbsp;&nbsp;&nbsp;&nbsp; Versant Ventures VI GP, L.P.

2. &nbsp;&nbsp;&nbsp;&nbsp; Check the Appropriate Box
if a Member of a Group (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; (a) ☐ (b) ☒(1)

3. &nbsp;&nbsp;&nbsp;&nbsp; SEC USE ONLY

4. &nbsp;&nbsp;&nbsp;&nbsp; Source of Funds (see
instructions) &nbsp;&nbsp;&nbsp;&nbsp; AF

5. &nbsp;&nbsp;&nbsp;&nbsp; Check if Disclosure of
Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e) &nbsp;&nbsp;&nbsp;&nbsp; ☐

6. &nbsp;&nbsp;&nbsp;&nbsp; Citizenship or Place of
Organization &nbsp;&nbsp;&nbsp;&nbsp; Delaware

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;7. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;8. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;2,094,451 Common Shares (2) |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;9. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 10. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;2,094,451 Common Shares (2) |

---

11. &nbsp;&nbsp;&nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person &nbsp;&nbsp;&nbsp;&nbsp; 2,094,451 Common Shares (2)

12. &nbsp;&nbsp;&nbsp;&nbsp; Check if the Aggregate
Amount in Row (11) Excludes Certain Shares (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; ☐

13. &nbsp;&nbsp;&nbsp;&nbsp; Percent of Class
Represented by Amount in Row 11 &nbsp;&nbsp;&nbsp;&nbsp; 5.0% (3)

14. &nbsp;&nbsp;&nbsp;&nbsp; Type of Reporting Person
(see instructions) &nbsp;&nbsp;&nbsp;&nbsp; PN

(1) This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a
"group" for purposes of this Schedule 13D.

(2) These shares are held by Versant VI. LLC VI is the general partner of GP VI, which is the general partner of
Versant VI. Each of LLC VI and GP VI share voting and dispositive power over the shares held by Versant VI and as a result may be deemed to have beneficial ownership over such securities.

(3) This calculation is based upon 41,961,510 shares of the Issuer's Common Shares outstanding as of
October 31, 2022, as reported in the Form 10-Q.

------

CUSIP No. 760273102 13D

1. &nbsp;&nbsp;&nbsp;&nbsp; Name of Reporting Persons &nbsp;&nbsp;&nbsp;&nbsp; Versant Ventures VI GP-GP, LLC

2. &nbsp;&nbsp;&nbsp;&nbsp; Check the Appropriate Box
if a Member of a Group (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; (a) ☐ (b) ☒(1)

3. &nbsp;&nbsp;&nbsp;&nbsp; SEC USE ONLY

4. &nbsp;&nbsp;&nbsp;&nbsp; Source of Funds (see
instructions) &nbsp;&nbsp;&nbsp;&nbsp; AF

5. &nbsp;&nbsp;&nbsp;&nbsp; Check if Disclosure of
Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e) &nbsp;&nbsp;&nbsp;&nbsp; ☐

6. &nbsp;&nbsp;&nbsp;&nbsp; Citizenship or Place of
Organization &nbsp;&nbsp;&nbsp;&nbsp; Delaware

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;7. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;8. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;2,094,451 Common Shares (2) |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;9. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 10. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;2,094,451 Common Shares (2) |

---

11. &nbsp;&nbsp;&nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person &nbsp;&nbsp;&nbsp;&nbsp; 2,094,451 Common Shares (2)

12. &nbsp;&nbsp;&nbsp;&nbsp; Check if the Aggregate
Amount in Row (11) Excludes Certain Shares (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; ☐

13. &nbsp;&nbsp;&nbsp;&nbsp; Percent of Class
Represented by Amount in Row 11 &nbsp;&nbsp;&nbsp;&nbsp; 5.0% (3)

14. &nbsp;&nbsp;&nbsp;&nbsp; Type of Reporting Person
(see instructions) &nbsp;&nbsp;&nbsp;&nbsp; OO

(1) This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a
"group" for purposes of this Schedule 13D.

(2) These shares are held by Versant VI. LLC VI is the general partner of GP VI, which is the general partner of
Versant VI. Each of LLC VI and GP VI share voting and dispositive power over the shares held by Versant VI and as a result may be deemed to have beneficial ownership over such securities.

(3) This calculation is based upon 41,961,510 shares of the Issuer's Common Shares outstanding as of
October 31, 2022, as reported in the Form 10-Q.

------

CUSIP No. 760273102 13D

1. &nbsp;&nbsp;&nbsp;&nbsp; Name of Reporting Persons &nbsp;&nbsp;&nbsp;&nbsp; Versant Vantage I, L.P.

2. &nbsp;&nbsp;&nbsp;&nbsp; Check the Appropriate Box
if a Member of a Group (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; (a) ☐ (b) ☒(1)

3. &nbsp;&nbsp;&nbsp;&nbsp; SEC USE ONLY

4. &nbsp;&nbsp;&nbsp;&nbsp; Source of Funds (see
instructions) &nbsp;&nbsp;&nbsp;&nbsp; WC

5. &nbsp;&nbsp;&nbsp;&nbsp; Check if Disclosure of
Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e) &nbsp;&nbsp;&nbsp;&nbsp; ☐

6. &nbsp;&nbsp;&nbsp;&nbsp; Citizenship or Place of
Organization &nbsp;&nbsp;&nbsp;&nbsp; Delaware

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;7. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;231,211 Common Shares (2) |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;8. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;9. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;231,211 Common Shares (2) |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 10. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |

---

11. &nbsp;&nbsp;&nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person &nbsp;&nbsp;&nbsp;&nbsp; 231,211 Common Shares (2)

12. &nbsp;&nbsp;&nbsp;&nbsp; Check if the Aggregate
Amount in Row (11) Excludes Certain Shares (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; ☐

13. &nbsp;&nbsp;&nbsp;&nbsp; Percent of Class
Represented by Amount in Row 11 &nbsp;&nbsp;&nbsp;&nbsp; 0.6% (3)

14. &nbsp;&nbsp;&nbsp;&nbsp; Type of Reporting Person
(see instructions) &nbsp;&nbsp;&nbsp;&nbsp; PN

(1) This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a
"group" for purposes of this Schedule 13D.

(2) These shares are held by Vantage LP. Vantage LLC is the general partner of Vantage GP, which is the general
partner of Vantage LP. Each of Vantage LLC and Vantage GP share voting and dispositive power over the shares held by Vantage LP and as a result may be deemed to have beneficial ownership over such securities.

(3) This calculation is based upon 41,961,510 shares of the Issuer's Common Shares outstanding as of
October 31, 2022, as reported in the Form 10-Q.

------

CUSIP No. 760273102 13D

1. &nbsp;&nbsp;&nbsp;&nbsp; Name of Reporting Persons &nbsp;&nbsp;&nbsp;&nbsp; Versant Vantage I GP, L.P.

2. &nbsp;&nbsp;&nbsp;&nbsp; Check the Appropriate Box
if a Member of a Group (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; (a) ☐ (b) ☒(1)

3. &nbsp;&nbsp;&nbsp;&nbsp; SEC USE ONLY

4. &nbsp;&nbsp;&nbsp;&nbsp; Source of Funds (see
instructions) &nbsp;&nbsp;&nbsp;&nbsp; AF

5. &nbsp;&nbsp;&nbsp;&nbsp; Check if Disclosure of
Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e) &nbsp;&nbsp;&nbsp;&nbsp; ☐

6. &nbsp;&nbsp;&nbsp;&nbsp; Citizenship or Place of
Organization &nbsp;&nbsp;&nbsp;&nbsp; Delaware

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;7. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;8. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;231,211 Common Shares (2) |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;9. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 10. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;231,211 Common Shares (2) |

---

11. &nbsp;&nbsp;&nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person &nbsp;&nbsp;&nbsp;&nbsp; 231,211 Common Shares (2)

12. &nbsp;&nbsp;&nbsp;&nbsp; Check if the Aggregate
Amount in Row (11) Excludes Certain Shares (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; ☐

13. &nbsp;&nbsp;&nbsp;&nbsp; Percent of Class
Represented by Amount in Row 11 &nbsp;&nbsp;&nbsp;&nbsp; 0.6% (3)

14. &nbsp;&nbsp;&nbsp;&nbsp; Type of Reporting Person
(see instructions) &nbsp;&nbsp;&nbsp;&nbsp; PN

(1) This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a
"group" for purposes of this Schedule 13D.

(2) These shares are held by Vantage LP. Vantage LLC is the general partner of Vantage GP, which is the general
partner of Vantage LP. Each of Vantage LLC and Vantage GP share voting and dispositive power over the shares held by Vantage LP and as a result may be deemed to have beneficial ownership over such securities.

(3) This calculation is based upon 41,961,510 shares of the Issuer's Common Shares outstanding as of
October 31, 2022, as reported in the Form 10-Q.

------

CUSIP No. 760273102 13D

1. &nbsp;&nbsp;&nbsp;&nbsp; Name of Reporting Persons &nbsp;&nbsp;&nbsp;&nbsp; Versant Vantage I GP-GP, LLC

2. &nbsp;&nbsp;&nbsp;&nbsp; Check the Appropriate Box
if a Member of a Group (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; (a) ☐ (b) ☒(1)

3. &nbsp;&nbsp;&nbsp;&nbsp; SEC USE ONLY

4. &nbsp;&nbsp;&nbsp;&nbsp; Source of Funds (see
instructions) &nbsp;&nbsp;&nbsp;&nbsp; AF

5. &nbsp;&nbsp;&nbsp;&nbsp; Check if Disclosure of
Legal Proceedings Is Required Pursuant to Item 2(d) or 2(e) &nbsp;&nbsp;&nbsp;&nbsp; ☐

6. &nbsp;&nbsp;&nbsp;&nbsp; Citizenship or Place of
Organization &nbsp;&nbsp;&nbsp;&nbsp; Delaware

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;7. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;8. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;231,211 Common Shares (2) |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | &nbsp;&nbsp;&nbsp;&nbsp;9. | &nbsp;&nbsp;&nbsp;&nbsp;Sole Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;0 |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 10. | &nbsp;&nbsp;&nbsp;&nbsp;Shared Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;231,211 Common Shares (2) |

---

11. &nbsp;&nbsp;&nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person &nbsp;&nbsp;&nbsp;&nbsp; 231,211 Common Shares (2)

12. &nbsp;&nbsp;&nbsp;&nbsp; Check if the Aggregate
Amount in Row (11) Excludes Certain Shares (see instructions) &nbsp;&nbsp;&nbsp;&nbsp; ☐

13. &nbsp;&nbsp;&nbsp;&nbsp; Percent of Class
Represented by Amount in Row 11 &nbsp;&nbsp;&nbsp;&nbsp; 0.6% (3)

14. &nbsp;&nbsp;&nbsp;&nbsp; Type of Reporting Person
(see instructions) &nbsp;&nbsp;&nbsp;&nbsp; OO

(1) This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a
"group" for purposes of this Schedule 13D.

(2) These shares are held by Vantage LP. Vantage LLC is the general partner of Vantage GP, which is the general
partner of Vantage LP. Each of Vantage LLC and Vantage GP share voting and dispositive power over the shares held by Vantage LP and as a result may be deemed to have beneficial ownership over such securities.

(3) This calculation is based upon 41,961,510 shares of the Issuer's Common Shares outstanding as of
October 31, 2022, as reported in the Form 10-Q.

------

CUSIP No. 760273102 13D

**Explanatory Note:** 

This Amendment No. 5 ("Amendment") amends and supplements the Schedule 13D originally filed by the Reporting Persons with the United States Securities and Exchange Commission (the "Commission") on July 7, 2020, as amended by Amendment No. 1 filed with the Commission on January 25, 2021, Amendment No. 2 filed with the Commission on February 26, 2021, Amendment No. 3 filed with the Commission on August 16, 2021 and Amendment No. 4 filed with the Commission on June 13, 2022 (collectively, the "Original 13D"). Only those items that are hereby reported are amended; all other items reported in the Original 13D remain unchanged. Information given in response to each item shall be deemed incorporated by reference in all other items, as applicable. Capitalized terms not defined in this Amendment have the meanings ascribed to them in the Original 13D.

**Item 5. Interest in Securities of the Issuer** 

Solely on behalf of, and only to the extent that it relates to the Reporting Persons, Item 5 of the Original 13D is hereby amended as follows:

(a) and (b) See Items 7-11 of the cover pages of this Amendment.

(c) On December 9, 2022, Versant VI sold 250,000 Common Shares at a weighted average price per share of $16.00 for aggregate proceeds of approximately $4,000,000.00.

On December 29, 2022, VVC V effected a pro rata distribution without additional consideration of 287,157 Common Shares to (i) VV V, its general partner, and (ii) its limited partners. VV V then effected a pro rata distribution without additional consideration of the shares that it received in connection with such distribution to its members.

On December 29, 2022, VAF V effected a pro rata distribution without additional consideration of 8,638 Common Shares to (i) VV V, its general partner, and (ii) its limited partners. VV V then effected a pro rata distribution without additional consideration of the shares that it received in connection with such distribution to its members.

On December 29, 2022, VOA effected a pro rata distribution without additional consideration of 9,561 Common Shares to (i) VV V, its general partner, and (ii) its limited partners. VV V then effected a pro rata distribution without additional consideration of the shares that it received in connection with such distribution to its members.

On December 29, 2022, VVC CAN effected a pro rata distribution without additional consideration of 21,854 Common Shares to (i) VV V CAN, its general partner, and (ii) its limited partners. VV V CAN then effected a pro rata distribution without additional consideration of the shares that it received in connection with such distribution to its limited partners.

------

**SIGNATURE** 

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

January 6, 2023

---

| |
|:---|
|  **Versant Venture Capital V, L.P.** |
|  By: Versant Ventures V, LLC |
|  Its: General Partner |

---

---

| | |
|:---|:---|
|  By: | /s/ Max Eisenberg |
|  | Max Eisenberg, Chief Operating Officer |

---

---

| |
|:---|
|  **Versant Affiliates Fund V, L.P.** |
|  By: Versant Ventures V, LLC |
|  Its: General Partner |

---

---

| | |
|:---|:---|
|  By: | /s/ Max Eisenberg |
|  | Max Eisenberg, Chief Operating Officer |

---

---

| | |
|:---|:---|
|  **Versant Ophthalmic Affiliates Fund I, L.P.** | **Versant Ophthalmic Affiliates Fund I, L.P.** |
|  By: Versant Ventures V, LLC | By: Versant Ventures V, LLC |
|  Its: General Partner | Its: General Partner |
| By: | /s/ Max Eisenberg |
|  | Max Eisenberg, Chief Operating Officer |

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| | |
|:---|:---|
|  **Versant Ventures V, LLC** | **Versant Ventures V, LLC** |
|  By: | /s/ Max Eisenberg |
|  | Max Eisenberg, Chief Operating Officer |

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| | |
|:---|:---|
|  **Versant Venture Capital V (Canada) LP** | **Versant Venture Capital V (Canada) LP** |
|  By: Versant Ventures V (Canada), L.P. | By: Versant Ventures V (Canada), L.P. |
|  Its: General Partner | Its: General Partner |
|  By: Versant Ventures V GP-GP (Canada), Inc. | By: Versant Ventures V GP-GP (Canada), Inc. |
|  Its: General Partner | Its: General Partner |
|  By: | /s/ Max Eisenberg |
|  | Max Eisenberg, Chief Operating Officer |

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| | |
|:---|:---|
|  **Versant Ventures V GP-GP (Canada), Inc.** | **Versant Ventures V GP-GP (Canada), Inc.** |
|  By: | /s/ Max Eisenberg |
|  | Max Eisenberg, Chief Operating Officer |

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| | |
|:---|:---|
|  **Versant Ventures V (Canada), L.P.** | **Versant Ventures V (Canada), L.P.** |
|  By: Versant Ventures V GP-GP (Canada), Inc. | By: Versant Ventures V GP-GP (Canada), Inc. |
|  Its: General Partner | Its: General Partner |
|  By: | /s/ Max Eisenberg |
|  | Max Eisenberg, Chief Operating Officer |

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| | |
|:---|:---|
|  **Versant Venture Capital VI, L.P.** | **Versant Venture Capital VI, L.P.** |
|  By: Versant Ventures VI GP, L.P. | By: Versant Ventures VI GP, L.P. |
|  Its: General Partner | Its: General Partner |
|  By: | Versant Ventures VI GP-GP, LLC |
|  Its: General Partner | Its: General Partner |
|  By: | /s/ Max Eisenberg |
|  | Max Eisenberg, Chief Operating Officer |
|  **Versant Ventures VI GP, L.P.** | **Versant Ventures VI GP, L.P.** |
|  By: Versant Ventures VI GP-GP, LLC | By: Versant Ventures VI GP-GP, LLC |
|  Its: General Partner | Its: General Partner |
|  By: | /s/ Max Eisenberg |
|  | Max Eisenberg, Chief Operating Officer |
|  **Versant Ventures VI GP-GP, LLC** | **Versant Ventures VI GP-GP, LLC** |
|  By: | /s/ Max Eisenberg |
|  | Max Eisenberg, Chief Operating Officer |
|  **Versant Vantage I, L.P.** | **Versant Vantage I, L.P.** |
|  By: Versant Vantage I GP, L.P. | By: Versant Vantage I GP, L.P. |
|  Its: General Partner | Its: General Partner |
|  By: Versant Vantage I GP-GP, LLC | By: Versant Vantage I GP-GP, LLC |
|  Its: General Partner | Its: General Partner |
|  By: | /s/ Max Eisenberg |
|  | Max Eisenberg, Chief Operating Officer |
|  **Versant Vantage I GP, L.P.** | **Versant Vantage I GP, L.P.** |
|  By: Versant Vantage I GP-GP, LLC | By: Versant Vantage I GP-GP, LLC |
|  Its: General Partner | Its: General Partner |
|  By: | /s/ Max Eisenberg |
|  | Max Eisenberg, Chief Operating Officer |
|  **Versant Vantage I GP-GP, LLC** | **Versant Vantage I GP-GP, LLC** |
|  By: | /s/ Max Eisenberg |
|  | Max Eisenberg, Chief Operating Officer |

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