# EDGAR Filing Document

**Accession Number:** 0001100663
**File Stem:** 0001410368-25-010277
**Filing Date:** 2025-9
**Character Count:** 21985
**Document Hash:** 2fa2bdf7f0eba48889f00a2b04517efa
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001410368-25-010277.hdr.sgml**: 20250924

**ACCESSION NUMBER**: 0001410368-25-010277

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20250731

**FILED AS OF DATE**: 20250924

**DATE AS OF CHANGE**: 20250924

**PERIOD START**: 20250731

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** iSHARES TRUST
- **CENTRAL INDEX KEY:** 0001100663

**ORGANIZATION NAME:**
- **EIN:** 943351276
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-09729
- **FILM NUMBER:** 251338764

**BUSINESS ADDRESS:**
- **STREET 1:** 400 HOWARD STREET
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94105
- **BUSINESS PHONE:** (415) 670-2000

**MAIL ADDRESS:**
- **STREET 1:** 400 HOWARD STREET
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94105

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ISHARES TRUST
- **DATE OF NAME CHANGE:** 19991213

## Series and Classes Contracts Data

### iShares Neuroscience and Healthcare ETF (Series ID: S000076483)

| Class ID   | Class Name                              | Ticker Symbol   |
|:---|:---|:---|
| C000236410 | iShares Neuroscience and Healthcare ETF | IBRN            |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** iShares Trust

- **b. Investment Company Act file number:** 811-09729

- **c. CIK number of Registrant:** 0001100663

- **d. LEI of Registrant:** 5493000860OXIC4B5K91

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 400 Howard Street

  - **City:** San Francisco

  - **State:** CA

  - **Foreign country:** US

  - **Zip / Postal Code:** 94105

  - **Telephone number:** 800-474-2737

**Item A.2. Information about the Series.**

- **a. Name of Series:** iShares Neuroscience and Healthcare ETF

- **b. EDGAR series identifier (if any):** S000076483

- **c. LEI of Series:** 549300JGI839T0141L50

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2025-07-31

- **b. Date as of which information is reported:** 2025-07-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $5695504.46

**Total Liabilities:** $2196700.44

**Net Assets:** $3498804.02

**Cash Not Reported:** $8447.41

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000236410 | -3.21%               | -0.20%               | 6.52%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $421.78                  | $-108862.59                                |
| Month 2  | $-43672.19               | $36817.27                                  |
| Month 3  | $0.00                    | $213429.36                                 |

### Schedule of Portfolio Investments

| Name                               | Title                                                 | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| H Lundbeck A/S                     | H Lundbeck A/S                                        | CUSIP: 000000000<br>LEI: 5493006R4KC2OI5D3470 | Long             | EC               | CORP              | DK        |     21494 | NS      | $111978.55    | 3.20%             |  |  |  | No            |                  2 | On Loan: No      |
| Taysha Gene Therapies Inc          | Taysha Gene Therapies Inc                             | CUSIP: 877619106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     17152 | NS      | $46824.96     | 1.34%             |  |  |  | No            |                  1 | On Loan: —       |
| Anavex Life Sciences Corp          | Anavex Life Sciences Corp                             | CUSIP: 032797300<br>LEI: 549300K1I5L8COCQ8W36 | Long             | EC               | CORP              | US        |      6632 | NS      | $74941.60     | 2.14%             |  |  |  | No            |                  1 | On Loan: —       |
| Entrada Therapeutics Inc           | Entrada Therapeutics Inc                              | CUSIP: 29384C108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1742 | NS      | $10242.96     | 0.29%             |  |  |  | No            |                  1 | On Loan: —       |
| Solid Biosciences Inc              | Solid Biosciences Inc                                 | CUSIP: 83422E204<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4491 | NS      | $30718.44     | 0.88%             |  |  |  | No            |                  1 | On Loan: No      |
| Catalyst Pharmaceuticals Inc       | Catalyst Pharmaceuticals Inc                          | CUSIP: 14888U101<br>LEI: 5299004O0R5XXLA5H544 | Long             | EC               | CORP              | US        |      5561 | NS      | $118616.13    | 3.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Dyne Therapeutics Inc              | Dyne Therapeutics Inc                                 | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6849 | NS      | $67462.65     | 1.93%             |  |  |  | No            |                  1 | On Loan: No      |
| Axogen Inc                         | Axogen Inc                                            | CUSIP: 05463X106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3452 | NS      | $45186.68     | 1.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Dynavox Group AB                   | Dynavox Group AB                                      | CUSIP: 000000000<br>LEI: 5493008X1XZR4R5R0P66 | Long             | EC               | CORP              | SE        |      7740 | NS      | $100049.92    | 2.86%             |  |  |  | No            |                  2 | On Loan: No      |
| MicroPort NeuroScientific Corp     | MicroPort NeuroScientific Corp                        | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |     17000 | NS      | $31045.14     | 0.89%             |  |  |  | No            |                  2 | On Loan: No      |
| SK Biopharmaceuticals Co Ltd       | SK Biopharmaceuticals Co Ltd                          | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | KR        |      2156 | NS      | $151841.57    | 4.34%             |  |  |  | No            |                  2 | On Loan: No      |
| Vanda Pharmaceuticals Inc          | Vanda Pharmaceuticals Inc                             | CUSIP: 921659108<br>LEI: 529900AY8VOOQBKJ0O70 | Long             | EC               | CORP              | US        |      4417 | NS      | $18816.42     | 0.54%             |  |  |  | No            |                  1 | On Loan: No      |
| Supernus Pharmaceuticals Inc       | Supernus Pharmaceuticals Inc                          | CUSIP: 868459108<br>LEI: 549300GRM36VBKISYJ58 | Long             | EC               | CORP              | US        |      4259 | NS      | $149490.90    | 4.27%             |  |  |  | No            |                  1 | On Loan: No      |
| Alector Inc                        | Alector Inc                                           | CUSIP: 014442107<br>LEI: 549300Z8RQOIY1JMHC25 | Long             | EC               | CORP              | US        |      6196 | NS      | $9232.04      | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| BioArctic AB                       | BioArctic AB                                          | CUSIP: 000000000<br>LEI: 549300Y0OI2WVUNHLC33 | Long             | EC               | CORP              | SE        |      3170 | NS      | $69405.99     | 1.98%             |  |  |  | No            |                  2 | On Loan: —       |
| Biogen Inc                         | Biogen Inc                                            | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |      1079 | NS      | $138112.00    | 3.95%             |  |  |  | No            |                  1 | On Loan: No      |
| Ceribell Inc                       | Ceribell Inc                                          | CUSIP: 15678C102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1639 | NS      | $23601.60     | 0.67%             |  |  |  | No            |                  1 | On Loan: No      |
| BlackRock Funds III                | BlackRock Cash Funds: Institutional, SL Agency Shares | CUSIP: 066922519<br>LEI: 5493008LW2651I1QB503 | Long             | STIV             | RF                | US        |   1096146 | NS      | $1096584.54   | 31.34%            |  |  |  | No            |                  1 | On Loan: No      |
| ACADIA Pharmaceuticals Inc         | ACADIA Pharmaceuticals Inc                            | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |      6524 | NS      | $155466.92    | 4.44%             |  |  |  | No            |                  1 | On Loan: No      |
| Biohaven Ltd                       | Biohaven Ltd                                          | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | VG        |      7167 | NS      | $108221.70    | 3.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Dianthus Therapeutics Inc          | Dianthus Therapeutics Inc                             | CUSIP: 252828108<br>LEI: 549300Z3N6ODPCOFC890 | Long             | EC               | CORP              | US        |      1792 | NS      | $37040.64     | 1.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Cassava Sciences Inc               | Cassava Sciences Inc                                  | CUSIP: 14817C107<br>LEI: 529900XA0UG5JXABYF08 | Long             | EC               | CORP              | US        |      3600 | NS      | $7560.00      | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Integra LifeSciences Holdings Corp | Integra LifeSciences Holdings Corp                    | CUSIP: 457985208<br>LEI: WB7IJCYY8YFTENS4O147 | Long             | EC               | CORP              | US        |      5272 | NS      | $69274.08     | 1.98%             |  |  |  | No            |                  1 | On Loan: —       |
| Denali Therapeutics Inc            | Denali Therapeutics Inc                               | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |      9755 | NS      | $134911.65    | 3.86%             |  |  |  | No            |                  1 | On Loan: No      |
| Zevra Therapeutics Inc             | Zevra Therapeutics Inc                                | CUSIP: 488445206<br>LEI: 254900CU6T74V18Y1W18 | Long             | EC               | CORP              | US        |      4335 | NS      | $48161.85     | 1.38%             |  |  |  | No            |                  1 | On Loan: No      |
| Avadel Pharmaceuticals PLC         | Avadel Pharmaceuticals PLC                            | CUSIP: 000000000<br>LEI: 549300E27PTSG2RHC762 | Long             | EC               | CORP              | IE        |      7102 | NS      | $74642.02     | 2.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Bright Minds Biosciences Inc       | Bright Minds Biosciences Inc                          | CUSIP: 10919W405<br>LEI: N/A                  | Long             | EC               | CORP              | CA        |       586 | NS      | $19789.22     | 0.57%             |  |  |  | No            |                  1 | On Loan: No      |
| Medincell SA                       | Medincell SA                                          | CUSIP: 000000000<br>LEI: 969500R79U6PXCL2FF46 | Long             | EC               | CORP              | FR        |      1619 | NS      | $31409.23     | 0.90%             |  |  |  | No            |                  1 | On Loan: No      |
| Amylyx Pharmaceuticals Inc         | Amylyx Pharmaceuticals Inc                            | CUSIP: 03237H101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5249 | NS      | $42149.47     | 1.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Larimar Therapeutics Inc           | Larimar Therapeutics Inc                              | CUSIP: 517125100<br>LEI: 529900NCBZHTTJV6HX73 | Long             | EC               | CORP              | US        |      3049 | NS      | $10549.54     | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Prothena Corp PLC                  | Prothena Corp PLC                                     | CUSIP: 000000000<br>LEI: 5299009ZXQ8NIIJ8OL30 | Long             | EC               | CORP              | IE        |      3413 | NS      | $23447.31     | 0.67%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurogene Inc                      | Neurogene Inc                                         | CUSIP: 64135M105<br>LEI: 529900A7VIY892SZVW73 | Long             | EC               | CORP              | US        |       943 | NS      | $20529.11     | 0.59%             |  |  |  | No            |                  1 | On Loan: No      |
| Xenon Pharmaceuticals Inc          | Xenon Pharmaceuticals Inc                             | CUSIP: 98420N105<br>LEI: 549300XV44Q9Z1MIPQ03 | Long             | EC               | CORP              | CA        |      4533 | NS      | $138437.82    | 3.96%             |  |  |  | No            |                  1 | On Loan: —       |
| Rapport Therapeutics Inc           | Rapport Therapeutics Inc                              | CUSIP: 75383L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1398 | NS      | $20075.28     | 0.57%             |  |  |  | No            |                  1 | On Loan: —       |
| Edgewise Therapeutics Inc          | Edgewise Therapeutics Inc                             | CUSIP: 28036F105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6195 | NS      | $88340.70     | 2.52%             |  |  |  | No            |                  1 | On Loan: No      |
| Sarepta Therapeutics Inc           | Sarepta Therapeutics Inc                              | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |      3335 | NS      | $54760.70     | 1.57%             |  |  |  | No            |                  1 | On Loan: —       |
| Argenx SE                          | Argenx SE                                             | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |       245 | NS      | $164230.85    | 4.69%             |  |  |  | No            |                  1 | On Loan: —       |
| Idorsia Ltd                        | Idorsia Ltd                                           | CUSIP: 000000000<br>LEI: 506700XOVZUB107S5720 | Long             | EC               | CORP              | CH        |     12548 | NS      | $53897.86     | 1.54%             |  |  |  | No            |                  2 | On Loan: No      |
| Sangamo Therapeutics Inc           | Sangamo Therapeutics Inc                              | CUSIP: 800677106<br>LEI: 2549006WMRKRC4G32Z67 | Long             | EC               | CORP              | US        |     19103 | NS      | $10260.22     | 0.29%             |  |  |  | No            |                  1 | On Loan: —       |
| Neuren Pharmaceuticals Ltd         | Neuren Pharmaceuticals Ltd                            | CUSIP: 000000000<br>LEI: 984500E48D0FDEE7CE63 | Long             | EC               | CORP              | NZ        |      8775 | NS      | $96222.48     | 2.75%             |  |  |  | No            |                  2 | On Loan: No      |
| Praxis Precision Medicines Inc     | Praxis Precision Medicines Inc                        | CUSIP: 74006W207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1463 | NS      | $79323.86     | 2.27%             |  |  |  | No            |                  1 | On Loan: No      |
| Voyager Therapeutics Inc           | Voyager Therapeutics Inc                              | CUSIP: 92915B106<br>LEI: 54930082S4XVR0ZWCC74 | Long             | EC               | CORP              | US        |      3598 | NS      | $11477.62     | 0.33%             |  |  |  | No            |                  1 | On Loan: —       |
| Neurocrine Biosciences Inc         | Neurocrine Biosciences Inc                            | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |      1144 | NS      | $146695.12    | 4.19%             |  |  |  | No            |                  1 | On Loan: —       |
| SanBio Co Ltd                      | SanBio Co Ltd                                         | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | JP        |      4300 | NS      | $64595.53     | 1.85%             |  |  |  | No            |                  2 | On Loan: No      |
| Abeona Therapeutics Inc            | Abeona Therapeutics Inc                               | CUSIP: 00289Y206<br>LEI: 54930002Z8PIJRCB4576 | Long             | EC               | CORP              | US        |      3626 | NS      | $23097.62     | 0.66%             |  |  |  | No            |                  1 | On Loan: —       |
| REGENXBIO Inc                      | REGENXBIO Inc                                         | CUSIP: 75901B107<br>LEI: 549300EOES47LATSET33 | Long             | EC               | CORP              | US        |      3652 | NS      | $31078.52     | 0.89%             |  |  |  | No            |                  1 | On Loan: No      |
| NeuroPace Inc                      | NeuroPace Inc                                         | CUSIP: 641288105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1861 | NS      | $15837.11     | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Alkermes PLC                       | Alkermes PLC                                          | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | IE        |      4523 | NS      | $119814.27    | 3.42%             |  |  |  | No            |                  1 | On Loan: —       |
| Scholar Rock Holding Corp          | Scholar Rock Holding Corp                             | CUSIP: 80706P103<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |      4203 | NS      | $155721.15    | 4.45%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC Therapeutics Inc               | PTC Therapeutics Inc                                  | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |      2760 | NS      | $143823.60    | 4.11%             |  |  |  | No            |                  1 | On Loan: —       |
| Capricor Therapeutics Inc          | Capricor Therapeutics Inc                             | CUSIP: 14070B309<br>LEI: 5493002ZI5PDLXV4DX14 | Long             | EC               | CORP              | US        |      3222 | NS      | $26355.96     | 0.75%             |  |  |  | No            |                  1 | On Loan: —       |
| Annexon Inc                        | Annexon Inc                                           | CUSIP: 03589W102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7586 | NS      | $18206.40     | 0.52%             |  |  |  | No            |                  1 | On Loan: —       |
| ClearPoint Neuro Inc               | ClearPoint Neuro Inc                                  | CUSIP: 18507C103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1956 | NS      | $20342.40     | 0.58%             |  |  |  | No            |                  1 | On Loan: —       |
| Fulcrum Therapeutics Inc           | Fulcrum Therapeutics Inc                              | CUSIP: 359616109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3889 | NS      | $26172.97     | 0.75%             |  |  |  | No            |                  1 | On Loan: —       |

### Signature

**Date Signed:** 2025-08-29

**Name of Applicant:** iShares Trust

**Signature:** Chuck Pulsfort

**Name of Signer:** Chuck Pulsfort

**Title:** Assistant Treasurer