# EDGAR Filing Document

**Accession Number:** 0001854270
**File Stem:** 0001104659-23-019868
**Filing Date:** 2023-2
**Character Count:** 28088
**Document Hash:** 48fba50cc264201ec523854b0d2d51a4
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-23-019868.hdr.sgml**: 20230213

**ACCESSION NUMBER**: 0001104659-23-019868

**CONFORMED SUBMISSION TYPE**: SC 13G

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20230213

**DATE AS OF CHANGE**: 20230213

**GROUP MEMBERS**: BAYER AKTIENGESELLSCHAFT

**GROUP MEMBERS**: BAYER US HOLDING LP

**GROUP MEMBERS**: BAYER WORLD INVESTMENTS B.V.

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Senti Biosciences, Inc.
- **CENTRAL INDEX KEY:** 0001854270
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **IRS NUMBER:** 862437900
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-92581
- **FILM NUMBER:** 23619903

**BUSINESS ADDRESS:**
- **STREET 1:** 2 CORPORATE DRIVE, FIRST FLOOR
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080
- **BUSINESS PHONE:** (650) 382-3281

**MAIL ADDRESS:**
- **STREET 1:** 2 CORPORATE DRIVE, FIRST FLOOR
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Senti Biosciences, Inc.\
- **DATE OF NAME CHANGE:** 20220615

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Dynamics Special Purpose Corp.
- **DATE OF NAME CHANGE:** 20210331
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** BAYER HEALTHCARE LLC
- **CENTRAL INDEX KEY:** 0001231517
- **IRS NUMBER:** 061653795
- **STATE OF INCORPORATION:** DE

**FILING VALUES:**
- **FORM TYPE:** SC 13G

**BUSINESS ADDRESS:**
- **STREET 1:** 511 BENEDICT AVE.
- **CITY:** TARRYTOWN
- **STATE:** NY
- **ZIP:** 10591-5097

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**WASHINGTON, D.C. 20549**

**SCHEDULE 13G**

**(Amendment No.)\***

**Under the Securities Exchange Act of 1934**

Senti Biosciences, Inc.

(Name of Issuer)

Common Stock, par value $0.0001 per share

(Title of Class of Securities)

81726A100

(CUSIP Number)

December 31, 2022

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

◻ Rule 13d-1(b)

◻ Rule 13d-1(c)

⌧ Rule 13d-1(d)

\*The remainder of this cover page shall be filled out for a reporting person's initial filing of this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act.

---

| | |
|:---|:---|
| **CUSIP No. 81726A100** | **Page 2 of 10 Pages** |

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---

| | | | |
|:---|:---|:---|:---|
| 1. | Name of Reporting Person | Name of Reporting Person | Name of Reporting Person |
| | Bayer HealthCare LLC | Bayer HealthCare LLC | Bayer HealthCare LLC |
| 2. | Check the Appropriate Box if a Member of a Group | Check the Appropriate Box if a Member of a Group | Check the Appropriate Box if a Member of a Group |
|  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) ◻ | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) ◻ | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) ◻ |
| | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ⌧ | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ⌧ | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ⌧ |
| 3. | SEC Use Only | SEC Use Only | SEC Use Only |
| 4. | Citizenship or Place of Organization | Citizenship or Place of Organization | Citizenship or Place of Organization |
| | Delaware | Delaware | Delaware |
| | | 5. | Sole Voting Power |
| Number of | Number of | | 0 |
| Shares | Shares | 6. | Shared Voting Power |
| Beneficially | Beneficially |  |  |
| Owned By | Owned By | | 5,878,488 |
| Each Reporting | Each Reporting | 7. | Sole Dispositive Power |
| Person with | Person with |  |  |
| | | | 0 |
| | | 8. | Shared Dispositive Power |
| | | | 5,878,488 |
| 9. | Aggregate Amount Beneficially Owned by Each Reporting Person | Aggregate Amount Beneficially Owned by Each Reporting Person | Aggregate Amount Beneficially Owned by Each Reporting Person |
| | 5,878,488 | 5,878,488 | 5,878,488 |
| 10. | Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares | Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares | Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares |
| | Not Applicable | Not Applicable | Not Applicable |
| 11. | Percent of Class Represented by Amount in Row (9) | Percent of Class Represented by Amount in Row (9) | Percent of Class Represented by Amount in Row (9) |
| | 13.4%<sup>1</sup> | 13.4%<sup>1</sup> | 13.4%<sup>1</sup> |
| 12. | Type of Reporting Person | Type of Reporting Person | Type of Reporting Person |
| | CO | CO | CO |

---

<sup>1</sup> This percentage is based on 43,857,077 shares of common stock, $0.0001 par value per share (the "**Common Stock**") of Senti Biosciences, Inc., a Delaware corporation (the "**Issuer**"), outstanding as of November 3, 2022, as reported in the Issuer's Quarterly Report on Form 10-Q for the quarterly period ended September 30, 2022 (the "**Form 10-Q**"), as filed with the Securities and Exchange Commission (the "**SEC**") on November 10, 2022.

---

| | |
|:---|:---|
| **CUSIP No. 81726A100** | **Page 3 of 10 Pages** |

---

---

| | | | |
|:---|:---|:---|:---|
| 1. | Name of Reporting Person | Name of Reporting Person | Name of Reporting Person |
| | Bayer US Holding LP | Bayer US Holding LP | Bayer US Holding LP |
| 2. | Check the Appropriate Box if a Member of a Group | Check the Appropriate Box if a Member of a Group | Check the Appropriate Box if a Member of a Group |
|  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) ◻ | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) ◻ | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) ◻ |
| | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ⌧ | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ⌧ | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ⌧ |
| 3. | SEC Use Only | SEC Use Only | SEC Use Only |
| 4. | Citizenship or Place of Organization | Citizenship or Place of Organization | Citizenship or Place of Organization |
| | Delaware | Delaware | Delaware |
| | | 5. | Sole Voting Power |
| Number of | Number of | | 0 |
| Shares | Shares | 6. | Shared Voting Power |
| Beneficially | Beneficially |  |  |
| Owned By | Owned By | | 5,878,488 |
| Each Reporting | Each Reporting | 7. | Sole Dispositive Power |
| Person with | Person with |  |  |
| | | | 0 |
| | | 8. | Shared Dispositive Power |
| | | | 5,878,488 |
| 9. | Aggregate Amount Beneficially Owned by Each Reporting Person | Aggregate Amount Beneficially Owned by Each Reporting Person | Aggregate Amount Beneficially Owned by Each Reporting Person |
| | 5,878,488 | 5,878,488 | 5,878,488 |
| 10. | Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares | Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares | Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares |
| | Not Applicable | Not Applicable | Not Applicable |
| 11. | Percent of Class Represented by Amount in Row (9) | Percent of Class Represented by Amount in Row (9) | Percent of Class Represented by Amount in Row (9) |
| | 13.4%<sup>2</sup> | 13.4%<sup>2</sup> | 13.4%<sup>2</sup> |
| 12. | Type of Reporting Person | Type of Reporting Person | Type of Reporting Person |
| | PN | PN | PN |

---

<sup>2</sup> This percentage is based on 43,857,077 shares of the Issuer's Common Stock outstanding as of November 3, 2022, as reported in the Issuer's Form 10-Q, as filed with the SEC on November 10, 2022.

---

| | |
|:---|:---|
| **CUSIP No. 81726A100** | **Page 4 of 10 Pages** |

---

---

| | | | |
|:---|:---|:---|:---|
| 1. | Name of Reporting Person | Name of Reporting Person | Name of Reporting Person |
| | Bayer World Investments B.V. | Bayer World Investments B.V. | Bayer World Investments B.V. |
| 2. | Check the Appropriate Box if a Member of a Group | Check the Appropriate Box if a Member of a Group | Check the Appropriate Box if a Member of a Group |
|  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) ◻ | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) ◻ | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) ◻ |
| | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ⌧ | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ⌧ | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ⌧ |
| 3. | SEC Use Only | SEC Use Only | SEC Use Only |
| 4. | Citizenship or Place of Organization | Citizenship or Place of Organization | Citizenship or Place of Organization |
| | The Netherlands | The Netherlands | The Netherlands |
| | | 5. | Sole Voting Power |
| Number of | Number of | | 0 |
| Shares | Shares | 6. | Shared Voting Power |
| Beneficially | Beneficially |  |  |
| Owned By | Owned By | | 5,878,488 |
| Each Reporting | Each Reporting | 7. | Sole Dispositive Power |
| Person with | Person with |  |  |
| | | | 0 |
| | | 8. | Shared Dispositive Power |
| | | | 5,878,488 |
| 9. | Aggregate Amount Beneficially Owned by Each Reporting Person | Aggregate Amount Beneficially Owned by Each Reporting Person | Aggregate Amount Beneficially Owned by Each Reporting Person |
| | 5,878,488 | 5,878,488 | 5,878,488 |
| 10. | Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares | Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares | Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares |
| | Not Applicable | Not Applicable | Not Applicable |
| 11. | Percent of Class Represented by Amount in Row (9) | Percent of Class Represented by Amount in Row (9) | Percent of Class Represented by Amount in Row (9) |
| | 13.4%<sup>3</sup> | 13.4%<sup>3</sup> | 13.4%<sup>3</sup> |
| 12. | Type of Reporting Person | Type of Reporting Person | Type of Reporting Person |
| | CO | CO | CO |

---

<sup>3</sup> This percentage is based on 43,857,077 shares of the Issuer's Common Stock outstanding as of November 3, 2022, as reported in the Issuer's Form 10-Q, as filed with the SEC on November 10, 2022.

---

| | |
|:---|:---|
| **CUSIP No. 81726A100** | **Page 5 of 10 Pages** |

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| | | | |
|:---|:---|:---|:---|
| 1. | Name of Reporting Person | Name of Reporting Person | Name of Reporting Person |
| | Bayer Aktiengesellschaft | Bayer Aktiengesellschaft | Bayer Aktiengesellschaft |
| 2. | Check the Appropriate Box if a Member of a Group | Check the Appropriate Box if a Member of a Group | Check the Appropriate Box if a Member of a Group |
|  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) ◻ | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) ◻ | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) ◻ |
| | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ⌧ | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ⌧ | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ⌧ |
| 3. | SEC Use Only | SEC Use Only | SEC Use Only |
| 4. | Citizenship or Place of Organization | Citizenship or Place of Organization | Citizenship or Place of Organization |
| | Germany | Germany | Germany |
| | | 5. | Sole Voting Power |
| Number of | Number of | | 0 |
| Shares | Shares | 6. | Shared Voting Power |
| Beneficially | Beneficially |  |  |
| Owned By | Owned By | | 5,878,488 |
| Each Reporting | Each Reporting | 7. | Sole Dispositive Power |
| Person with | Person with |  |  |
| | | | 0 |
| | | 8. | Shared Dispositive Power |
| | | | 5,878,488 |
| 9. | Aggregate Amount Beneficially Owned by Each Reporting Person | Aggregate Amount Beneficially Owned by Each Reporting Person | Aggregate Amount Beneficially Owned by Each Reporting Person |
| | 5,878,488 | 5,878,488 | 5,878,488 |
| 10. | Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares | Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares | Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares |
| | Not Applicable | Not Applicable | Not Applicable |
| 11. | Percent of Class Represented by Amount in Row (9) | Percent of Class Represented by Amount in Row (9) | Percent of Class Represented by Amount in Row (9) |
| | 13.4%<sup>4</sup> | 13.4%<sup>4</sup> | 13.4%<sup>4</sup> |
| 12. | Type of Reporting Person | Type of Reporting Person | Type of Reporting Person |
| | HC, CO | HC, CO | HC, CO |

---

<sup>4</sup> This percentage is based on 43,857,077 shares of the Issuer's Common Stock outstanding as of November 3, 2022, as reported in the Issuer's Form 10-Q, as filed with the SEC on November 10, 2022.

---

| | |
|:---|:---|
| **CUSIP No. 81726A100** | **Page 6 of 10 Pages** |

---

---

| | |
|:---|:---|
| **Item 1(a)** | **Name of Issuer** |

---

Senti Biosciences, Inc. (the "**Issuer**")

---

| | |
|:---|:---|
| **Item 1(b)** | **Address of Issuer's Principal Executive Offices** |

---

2 Corporate Drive, First Floor, South San Francisco, California 94080

---

| | |
|:---|:---|
| **Item 2(a)** | **Name of Person Filing** |

---

This Schedule 13G is being jointly filed by Bayer HealthCare LLC ("**BHC**"), Bayer US Holdling LP ("**BUSH LP**"), Bayer World Investments B.V. ("**BWI**") and Bayer Aktiengesellschaft ("**Bayer**") (collectively, the "**Reporting Persons**").

---

| | |
|:---|:---|
| **Item 2(b)** | **Address of Principal Business Office, or if none, Residence** |

---

The business address for BHC and BUSH LP is 100 Bayer Boulevard, Whippany, New Jersey 07981.

The business address for BWI is Siriusdreef 36, 2132 WT Hoofddorp, The Netherlands 2132WT.

The business address for Bayer is Bayerwerk, Gebaeude W11, Kaiser-Wilhelm-Allee 1, Leverkusen, Germany 51373.

---

| | |
|:---|:---|
| **Item 2(c)** | **Citizenship** |

---

The Reporting Persons are citizens of:

BHC — Delaware

BUSH LP — Delaware

BWI — The Netherlands

Bayer — Germany

---

| | |
|:---|:---|
| **Item 2(d)** | **Title of Class of Securities** |

---

Common Stock, par value $0.0001 per share ("**Common Stock**")

---

| | |
|:---|:---|
| **Item 2(e)** | **CUSIP Number** |

---

81726A100

**Item 3.** **Filing pursuant to Rules 13d-1(b) or 13d-2(b) or (c)**

Not Applicable

**Item 4.** **Ownership**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) BHC is the direct beneficial owner of an aggregate of 5,878,488 shares of Common Stock, which represents 13.4% of the Issuer's outstanding Common Stock based upon 43,857,077 shares outstanding on November 3, 2022 as reported by the Issuer in its Form 10-Q as filed with the SEC on November 10, 2022.

BHC is controlled by BUSH LP. BWI is the general partner of BUSH LP. BWI is an indirect, wholly owned subsidiary of Bayer. Accordingly, Bayer may be deemed to be an indirect beneficial owner of the shares of Common Stock beneficially owned directly by BHC.

---

| | |
|:---|:---|
| **CUSIP No. 81726A100** | **Page 7 of 10 Pages** |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Percent of class:

BHC — 13.4%

BUSH LP — 13.4%

BWI — 13.4%

Bayer — 13.4%

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Number of shares as to which such person has:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) Sole power to vote or to direct the vote: 0

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) Shared power to vote or to direct the vote:

BHC — 5,878,488

BUSH LP — 5,878,488

BWI — 5,878,488

Bayer — 5,878,488

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) Sole power to dispose or to direct the disposition of: 0

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) Shared power to dispose or to direct the disposition of:

BHC — 5,878,488

BUSH LP — 5,878,488

BWI — 5,878,488

Bayer — 5,878,488

**Item 5.** **Ownership of Five Percent or Less of a Class**

Not Applicable

**Item 6.** **Ownership of More than Five Percent on Behalf of Another Person**

Not Applicable

**Item 7.** **Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company**

Not Applicable

**Item 8.** **Identification and Classification of Members of the Group**

Not Applicable

**Item 9.** **Notice of Dissolution of Group**

Not Applicable

**Item 10.** **Certification**

By signing below each of the undersigned certifies that, to the best of its knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under §240.14a-11.

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| | |
|:---|:---|
| **CUSIP No. 81726A100** | **Page 8 of 10 Pages** |

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**SIGNATURES**

After reasonable inquiry and to the best of its knowledge and belief, each of the undersigned certifies that the information set forth in this statement is true, complete and correct.

Date: February 13, 2023

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| | |
|:---|:---|
| BAYER HEALTHCARE LLC | BAYER HEALTHCARE LLC |
| By: | /s/ Keith R. Abrams |
|  | Keith R. Abrams, Assistant Secretary |
| BAYER US HOLDING LP | BAYER US HOLDING LP |
| By: | /s/ Keith R. Abrams |
|  | Keith R. Abrams, Assistant Secretary |
| BAYER WORLD INVESTMENTS B.V. | BAYER WORLD INVESTMENTS B.V. |
| By: | /s/ Patrick Lennaerts |
|  | Patrick Lennaerts, Managing Director |
| BAYER AKTIENGESELLSCHAFT | BAYER AKTIENGESELLSCHAFT |
| By: | /s/ Deny-Jean Silny |
|  | Deny-Jean Silny, Legal Head of Mergers & Acquisitions |

---

---

| | |
|:---|:---|
| **CUSIP No. 81726A100** | **Page 9 of 10 Pages** |

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**EXHIBIT INDEX**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A. Joint Filing Agreement, dated February 13, 2023, by and between Bayer HealthCare LLC, Bayer US Holding LP, Bayer World Investments B.V.
and Bayer Aktiengesellschaft.

---

| | |
|:---|:---|
| **CUSIP No. 81726A100** | **Page 10 of 10 Pages** |

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**EXHIBIT A**

JOINT FILING AGREEMENT

The undersigned hereby agree to jointly prepare and file with the United States Securities and Exchange Commission this Schedule 13G and any future amendments hereto (including amendments on Schedule 13D or Schedule 13G, as applicable) reporting each of the undersigned's ownership of securities of Senti Biosciences, Inc., and hereby affirm that such Schedule 13G is being filed on behalf of each of the undersigned pursuant to and in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended. The undersigned acknowledge that each shall be responsible for the timely filing of such amendments, and for the completeness and accuracy of the information concerning it contained therein, but shall not be responsible for the completeness and accuracy of the information concerning the other, except to the extent that it knows or has reason to believe that such information is inaccurate.

Date: February 13, 2023

---

| | |
|:---|:---|
| BAYER HEALTHCARE LLC | BAYER HEALTHCARE LLC |
| By: | /s/ Keith R. Abrams |
|  | Keith R. Abrams, Assistant Secretary |
| BAYER US HOLDING LP | BAYER US HOLDING LP |
| By: | /s/ Keith R. Abrams |
|  | Keith R. Abrams, Assistant Secretary |
| BAYER WORLD INVESTMENTS B.V. | BAYER WORLD INVESTMENTS B.V. |
| By: | /s/ Patrick Lennaerts |
|  | Patrick Lennaerts, Managing Director |
| BAYER AKTIENGESELLSCHAFT | BAYER AKTIENGESELLSCHAFT |
| By: | /s/ Deny-Jean Silny |
|  | Deny-Jean Silny, Legal Head of Mergers & Acquisitions |

---