# EDGAR Filing Document

**Accession Number:** 0001572661
**File Stem:** 0001752724-23-030719
**Filing Date:** 2023-2
**Character Count:** 91526
**Document Hash:** 4c23ed2f25f529f731cb68ac9a99d374
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001752724-23-030719.hdr.sgml**: 20230221

**ACCESSION NUMBER**: 0001752724-23-030719

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230221

**DATE AS OF CHANGE**: 20230221

**PERIOD START**: 20230630

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Principal Exchange-Traded Funds
- **CENTRAL INDEX KEY:** 0001572661
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 0630

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-23029
- **FILM NUMBER:** 23646620

**BUSINESS ADDRESS:**
- **STREET 1:** 711 HIGH STREET
- **CITY:** DES MOINES
- **STATE:** IA
- **ZIP:** 50392
- **BUSINESS PHONE:** 515-235-9328

**MAIL ADDRESS:**
- **STREET 1:** 711 HIGH STREET
- **CITY:** DES MOINES
- **STATE:** IA
- **ZIP:** 50392

## Series and Classes Contracts Data

### Principal Healthcare Innovators ETF (Series ID: S000054611)

| Class ID   | Class Name                          | Ticker Symbol   |
|:---|:---|:---|
| C000171494 | Principal Healthcare Innovators ETF | BTEC            |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** Principal Exchange-Traded Funds

- **b. Investment Company Act file number:** 811-23029

- **c. CIK number of Registrant:** 0001572661

- **d. LEI of Registrant:** 549300AG76V5U32HWF10

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 801 Grand Avenue

  - **City:** DES MOINES

  - **State:** IA

  - **Foreign country:** US

  - **Zip / Postal Code:** 50309

  - **Telephone number:** 515-235-1719

**Item A.2. Information about the Series.**

- **a. Name of Series:** Principal Healthcare Innovators ETF

- **b. EDGAR series identifier (if any):** S000054611

- **c. LEI of Series:** 549300HI5VZD2P4JPY17

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2023-06-30

- **b. Date as of which information is reported:** 2022-12-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $56690901.62

**Total Liabilities:** $1081281.05

**Net Assets:** $55609620.57

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000171494 | 0.18%                | 0.32%                | -2.37%               |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $-12379010.02            | $12518912.76                               |
| Month 2  | $-154049.77              | $348385.87                                 |
| Month 3  | $0.00                    | $-1342101.64                               |

### Schedule of Portfolio Investments

| Name                                   | Title                                                        | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Ionis Pharmaceuticals Inc              | Ionis Pharmaceuticals, Inc.                                  | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |     20772 | NS      | $784558.44    | 1.41%             |  |  |  | No            |                  1 | On Loan: No      |
| MiMedx Group Inc                       | MiMedx Group, Inc.                                           | CUSIP: 602496101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     21321 | NS      | $59272.38     | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Ligand Pharmaceuticals Inc             | Ligand Pharmaceuticals, Inc.                                 | CUSIP: 53220K504<br>LEI: 5493008K7TB0IKP37H79 | Long             | EC               | CORP              | US        |      2577 | NS      | $172143.60    | 0.31%             |  |  |  | No            |                  1 | On Loan: No      |
| 10X Genomics Inc                       | 10X Genomics, Inc.                                           | CUSIP: 88025U109<br>LEI: 5493003Z6741WNLG7H43 | Long             | EC               | CORP              | US        |     14320 | NS      | $521820.80    | 0.94%             |  |  |  | No            |                  1 | On Loan: No      |
| Absci Corp                             | Absci Corp.                                                  | CUSIP: 00091E109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     18653 | NS      | $39171.30     | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| 2seventy bio Inc                       | 2seventy bio, Inc.                                           | CUSIP: 901384107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6374 | NS      | $59724.38     | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Arrowhead Pharmaceuticals Inc          | Arrowhead Pharmaceuticals, Inc.                              | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |     15555 | NS      | $630910.80    | 1.13%             |  |  |  | No            |                  1 | On Loan: No      |
| KalVista Pharmaceuticals Inc           | KalVista Pharmaceuticals, Inc.                               | CUSIP: 483497103<br>LEI: 529900Q7IDA3WUGRZA51 | Long             | EC               | CORP              | US        |      6777 | NS      | $45812.52     | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Protagonist Therapeutics Inc           | Protagonist Therapeutics, Inc.                               | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8746 | NS      | $95418.86     | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Revance Therapeutics Inc               | Revance Therapeutics, Inc.                                   | CUSIP: 761330109<br>LEI: 549300N33TFDZHS81H11 | Long             | EC               | CORP              | US        |     11126 | NS      | $205385.96    | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals Inc            | Alnylam Pharmaceuticals, Inc.                                | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |      8295 | NS      | $1971306.75   | 3.54%             |  |  |  | No            |                  1 | On Loan: No      |
| Tactile Systems Technology Inc         | Tactile Systems Technology, Inc.                             | CUSIP: 87357P100<br>LEI: 54930069VDTITHOTKJ98 | Long             | EC               | CORP              | US        |      4874 | NS      | $55953.52     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Kezar Life Sciences Inc                | Kezar Life Sciences, Inc.                                    | CUSIP: 49372L100<br>LEI: 549300EV1V8GXBV18004 | Long             | EC               | CORP              | US        |     11730 | NS      | $82579.20     | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Anavex Life Sciences Corp              | Anavex Life Sciences Corp.                                   | CUSIP: 032797300<br>LEI: 549300K1I5L8COCQ8W36 | Long             | EC               | CORP              | US        |     12334 | NS      | $114212.84    | 0.21%             |  |  |  | No            |                  1 | On Loan: —       |
| Vera Therapeutics Inc                  | Vera Therapeutics, Inc.                                      | CUSIP: 92337R101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4862 | NS      | $94079.70     | 0.17%             |  |  |  | No            |                  1 | On Loan: —       |
| Lexicon Pharmaceuticals Inc            | Lexicon Pharmaceuticals, Inc.                                | CUSIP: 528872302<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     33607 | NS      | $64189.37     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Relay Therapeutics Inc                 | Relay Therapeutics, Inc.                                     | CUSIP: 75943R102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     17874 | NS      | $267037.56    | 0.48%             |  |  |  | No            |                  1 | On Loan: No      |
| Sight Sciences Inc                     | Sight Sciences, Inc.                                         | CUSIP: 82657M105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8773 | NS      | $107118.33    | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Kura Oncology Inc                      | Kura Oncology, Inc.                                          | CUSIP: 50127T109<br>LEI: 5493005QORQTZCZYOP39 | Long             | EC               | CORP              | US        |     10405 | NS      | $129126.05    | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Treace Medical Concepts Inc            | Treace Medical Concepts, Inc.                                | CUSIP: 89455T109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8524 | NS      | $195966.76    | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| SI-BONE Inc                            | SI-BONE, Inc.                                                | CUSIP: 825704109<br>LEI: 549300J8JGYVJJHV9C31 | Long             | EC               | CORP              | US        |      5709 | NS      | $77642.40     | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| BioCryst Pharmaceuticals Inc           | BioCryst Pharmaceuticals, Inc.                               | CUSIP: 09058V103<br>LEI: 549300Z0INP1Z5NP6J59 | Long             | EC               | CORP              | US        |     27585 | NS      | $316675.80    | 0.57%             |  |  |  | No            |                  1 | On Loan: No      |
| CinCor Pharma Inc                      | CinCor Pharma, Inc.                                          | CUSIP: 17240Y109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6533 | NS      | $80290.57     | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Inogen Inc                             | Inogen, Inc.                                                 | CUSIP: 45780L104<br>LEI: 549300J8WJIVTOJ8IH97 | Long             | EC               | CORP              | US        |      3980 | NS      | $78445.80     | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Exact Sciences Corp                    | Exact Sciences Corp.                                         | CUSIP: 30063P105<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |     25922 | NS      | $1283398.22   | 2.31%             |  |  |  | No            |                  1 | On Loan: No      |
| Intercept Pharmaceuticals Inc          | Intercept Pharmaceuticals, Inc.                              | CUSIP: 45845P108<br>LEI: 254900JMB8TX5P688V24 | Long             | EC               | CORP              | US        |      6932 | NS      | $85748.84     | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Caribou Biosciences Inc                | Caribou Biosciences, Inc.                                    | CUSIP: 142038108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     10176 | NS      | $63905.28     | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Verve Therapeutics Inc                 | Verve Therapeutics, Inc.                                     | CUSIP: 92539P101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      9012 | NS      | $174382.20    | 0.31%             |  |  |  | No            |                  1 | On Loan: No      |
| Keros Therapeutics Inc                 | Keros Therapeutics, Inc.                                     | CUSIP: 492327101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3999 | NS      | $192031.98    | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| BioLife Solutions Inc                  | BioLife Solutions, Inc.                                      | CUSIP: 09062W204<br>LEI: 549300G2IVCMC2TJDW72 | Long             | EC               | CORP              | US        |      6842 | NS      | $124524.40    | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Anika Therapeutics Inc                 | Anika Therapeutics, Inc.                                     | CUSIP: 035255108<br>LEI: 529900R9LS3Z0O6QH455 | Long             | EC               | CORP              | US        |      2637 | NS      | $78055.20     | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Adicet Bio Inc                         | Adicet Bio, Inc.                                             | CUSIP: 007002108<br>LEI: 549300VRD2QO80WBOP18 | Long             | EC               | CORP              | US        |      6545 | NS      | $58512.30     | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Cutera Inc                             | Cutera, Inc.                                                 | CUSIP: 232109108<br>LEI: 529900NPKPEWJWR21Z42 | Long             | EC               | CORP              | US        |      3123 | NS      | $138099.06    | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Ocugen Inc                             | Ocugen, Inc.                                                 | CUSIP: 67577C105<br>LEI: 549300JVNUI9CXWJLR09 | Long             | EC               | CORP              | US        |     39256 | NS      | $51032.80     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Prometheus Biosciences Inc             | Prometheus Biosciences, Inc.                                 | CUSIP: 74349U108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6134 | NS      | $674740.00    | 1.21%             |  |  |  | No            |                  1 | On Loan: No      |
| AtriCure Inc                           | AtriCure, Inc.                                               | CUSIP: 04963C209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7023 | NS      | $311680.74    | 0.56%             |  |  |  | No            |                  1 | On Loan: No      |
| Myriad Genetics Inc                    | Myriad Genetics, Inc.                                        | CUSIP: 62855J104<br>LEI: 52990044IHUOUMETT163 | Long             | EC               | CORP              | US        |     12254 | NS      | $177805.54    | 0.32%             |  |  |  | No            |                  1 | On Loan: No      |
| Instil Bio Inc                         | Instil Bio, Inc.                                             | CUSIP: 45783C101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     21717 | NS      | $13681.71     | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Aclaris Therapeutics Inc               | Aclaris Therapeutics, Inc.                                   | CUSIP: 00461U105<br>LEI: 5493000B2LQ9QTW1DF52 | Long             | EC               | CORP              | US        |     10389 | NS      | $163626.75    | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Nektar Therapeutics                    | Nektar Therapeutics                                          | CUSIP: 640268108<br>LEI: 5299005I24806IOIYE03 | Long             | EC               | CORP              | US        |     30877 | NS      | $69782.02     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Lyell Immunopharma Inc                 | Lyell Immunopharma, Inc.                                     | CUSIP: 55083R104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     37600 | NS      | $130472.00    | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| PMV Pharmaceuticals Inc                | PMV Pharmaceuticals, Inc.                                    | CUSIP: 69353Y103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7680 | NS      | $66816.00     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Dyne Therapeutics Inc                  | Dyne Therapeutics, Inc.                                      | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8611 | NS      | $99801.49     | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Axogen Inc                             | Axogen, Inc.                                                 | CUSIP: 05463X106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7285 | NS      | $72704.30     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Mesa Laboratories Inc                  | Mesa Laboratories, Inc.                                      | CUSIP: 59064R109<br>LEI: 549300ZCG738WLX8ZW79 | Long             | EC               | CORP              | US        |       887 | NS      | $147428.27    | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| Pacific Biosciences of California Inc  | Pacific Biosciences of California, Inc.                      | CUSIP: 69404D108<br>LEI: 529900F1BWRE1M0KZN89 | Long             | EC               | CORP              | US        |     33972 | NS      | $277890.96    | 0.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Theravance Biopharma Inc               | Theravance Biopharma, Inc.                                   | CUSIP: 000000000<br>LEI: 5493007VTSXP4Z6MIW52 | Long             | EC               | CORP              | KY        |     11078 | NS      | $124295.16    | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| OraSure Technologies Inc               | OraSure Technologies, Inc.                                   | CUSIP: 68554V108<br>LEI: 529900GNNJPNM4XHXQ77 | Long             | EC               | CORP              | US        |     14059 | NS      | $67764.38     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Phathom Pharmaceuticals Inc            | Phathom Pharmaceuticals, Inc.                                | CUSIP: 71722W107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7029 | NS      | $78865.38     | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| Allovir Inc                            | Allovir, Inc.                                                | CUSIP: 019818103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     15104 | NS      | $77483.52     | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Chinook Therapeutics Inc               | Chinook Therapeutics, Inc.                                   | CUSIP: 16961L106<br>LEI: 549300X0O3003W5QYQ48 | Long             | EC               | CORP              | US        |      9684 | NS      | $253720.80    | 0.46%             |  |  |  | No            |                  1 | On Loan: No      |
| Berkeley Lights Inc                    | Berkeley Lights, Inc.                                        | CUSIP: 084310101<br>LEI: 549300LTLRE4N65CD358 | Long             | EC               | CORP              | US        |     17257 | NS      | $46248.76     | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Geron Corp                             | Geron Corp.                                                  | CUSIP: 374163103<br>LEI: 549300T282D7Z2YESL90 | Long             | EC               | CORP              | US        |     60155 | NS      | $145575.10    | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Eagle Pharmaceuticals Inc/DE           | Eagle Pharmaceuticals, Inc.                                  | CUSIP: 269796108<br>LEI: 549300TN20OLYTJVP152 | Long             | EC               | CORP              | US        |      2365 | NS      | $69128.95     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Viridian Therapeutics Inc              | Viridian Therapeutics, Inc.                                  | CUSIP: 92790C104<br>LEI: 549300C775BNYF550E70 | Long             | EC               | CORP              | US        |      6168 | NS      | $180167.28    | 0.32%             |  |  |  | No            |                  1 | On Loan: No      |
| Axonics Inc                            | Axonics, Inc.                                                | CUSIP: 05465P101<br>LEI: 549300LJY4X7N57VJL05 | Long             | EC               | CORP              | US        |      7187 | NS      | $449403.11    | 0.81%             |  |  |  | No            |                  1 | On Loan: No      |
| Sage Therapeutics Inc                  | Sage Therapeutics, Inc.                                      | CUSIP: 78667J108<br>LEI: 5493000JX4BJS9W6CN35 | Long             | EC               | CORP              | US        |      8887 | NS      | $338950.18    | 0.61%             |  |  |  | No            |                  1 | On Loan: No      |
| iRhythm Technologies Inc               | iRhythm Technologies, Inc.                                   | CUSIP: 450056106<br>LEI: 549300FJI72RJGDQS384 | Long             | EC               | CORP              | US        |      4416 | NS      | $413646.72    | 0.74%             |  |  |  | No            |                  1 | On Loan: No      |
| OMNIAB INC                             | OmniAb, Inc.                                                 | CUSIP: 68218J301<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       977 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  2 | On Loan: No      |
| Beam Therapeutics Inc                  | Beam Therapeutics, Inc.                                      | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     10373 | NS      | $405688.03    | 0.73%             |  |  |  | No            |                  1 | On Loan: No      |
| Seres Therapeutics Inc                 | Seres Therapeutics, Inc.                                     | CUSIP: 81750R102<br>LEI: 549300GMXBE5NUWISF13 | Long             | EC               | CORP              | US        |     19920 | NS      | $111552.00    | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Adaptive Biotechnologies Corp          | Adaptive Biotechnologies Corp.                               | CUSIP: 00650F109<br>LEI: 549300ZTF7OT1FW66Q96 | Long             | EC               | CORP              | US        |     22626 | NS      | $172862.64    | 0.31%             |  |  |  | No            |                  1 | On Loan: No      |
| Travere Therapeutics Inc               | Travere Therapeutics, Inc.                                   | CUSIP: 89422G107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      9775 | NS      | $205568.25    | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Cardiovascular Systems Inc             | Cardiovascular Systems, Inc.                                 | CUSIP: 141619106<br>LEI: 549300NUBWKJMNMQ3287 | Long             | EC               | CORP              | US        |      6879 | NS      | $93691.98     | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Senseonics Holdings Inc                | Senseonics Holdings, Inc.                                    | CUSIP: 81727U105<br>LEI: 549300RCH6Z07TBHJ258 | Long             | EC               | CORP              | US        |     78525 | NS      | $80880.75     | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Erasca Inc                             | Erasca, Inc.                                                 | CUSIP: 29479A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     19364 | NS      | $83458.84     | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Collegium Pharmaceutical Inc           | Collegium Pharmaceutical, Inc.                               | CUSIP: 19459J104<br>LEI: 54930049FXZMTLW8D496 | Long             | EC               | CORP              | US        |      5692 | NS      | $132054.40    | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Y-mAbs Therapeutics Inc                | Y-mAbs Therapeutics, Inc.                                    | CUSIP: 984241109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7219 | NS      | $35228.72     | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Praxis Precision Medicines Inc         | Praxis Precision Medicines, Inc.                             | CUSIP: 74006W108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     15726 | NS      | $37427.88     | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| AnaptysBio Inc                         | AnaptysBio, Inc.                                             | CUSIP: 032724106<br>LEI: 529900HH4WQT03IG1A12 | Long             | EC               | CORP              | US        |      4553 | NS      | $141097.47    | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Seagen Inc                             | Seagen, Inc.                                                 | CUSIP: 81181C104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     12806 | NS      | $1645699.06   | 2.96%             |  |  |  | No            |                  1 | On Loan: No      |
| Novocure Ltd                           | Novocure Ltd.                                                | CUSIP: 000000000<br>LEI: 213800YPP55UMHWA4826 | Long             | EC               | CORP              | JE        |     15279 | NS      | $1120714.65   | 2.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Alector Inc                            | Alector, Inc.                                                | CUSIP: 014442107<br>LEI: 549300Z8RQOIY1JMHC25 | Long             | EC               | CORP              | US        |     13408 | NS      | $123755.84    | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Agios Pharmaceuticals Inc              | Agios Pharmaceuticals, Inc.                                  | CUSIP: 00847X104<br>LEI: 529900ONJHY8EOGYT555 | Long             | EC               | CORP              | US        |      8363 | NS      | $234833.04    | 0.42%             |  |  |  | No            |                  1 | On Loan: No      |
| Inari Medical Inc                      | Inari Medical, Inc.                                          | CUSIP: 45332Y109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7902 | NS      | $502251.12    | 0.90%             |  |  |  | No            |                  1 | On Loan: No      |
| Esperion Therapeutics Inc              | Esperion Therapeutics, Inc.                                  | CUSIP: 29664W105<br>LEI: 549300OFU56UKEWVUS92 | Long             | EC               | CORP              | US        |     11903 | NS      | $74155.69     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Monte Rosa Therapeutics Inc            | Monte Rosa Therapeutics, Inc.                                | CUSIP: 61225M102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8512 | NS      | $64776.32     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Precigen Inc                           | Precigen, Inc.                                               | CUSIP: 74017N105<br>LEI: 549300XCWNQU35K64G19 | Long             | EC               | CORP              | US        |     38054 | NS      | $57842.08     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Relmada Therapeutics Inc               | Relmada Therapeutics, Inc.                                   | CUSIP: 75955J402<br>LEI: 549300217EASRZ9JSF81 | Long             | EC               | CORP              | US        |      6744 | NS      | $23536.56     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| NuVasive Inc                           | NuVasive, Inc.                                               | CUSIP: 670704105<br>LEI: 549300C5ZB4NZ6TWM881 | Long             | EC               | CORP              | US        |      7783 | NS      | $320970.92    | 0.58%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcturus Therapeutics Holdings Inc     | Arcturus Therapeutics Holdings, Inc.                         | CUSIP: 03969T109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4768 | NS      | $80865.28     | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Intellia Therapeutics Inc              | Intellia Therapeutics, Inc.                                  | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |     11262 | NS      | $392931.18    | 0.71%             |  |  |  | No            |                  1 | On Loan: No      |
| Point Biopharma Global Inc             | Point Biopharma Global, Inc.                                 | CUSIP: 730541109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     16659 | NS      | $121444.11    | 0.22%             |  |  |  | No            |                  1 | On Loan: —       |
| Paragon 28 Inc                         | Paragon 28, Inc.                                             | CUSIP: 69913P105<br>LEI: 254900GM24PT1FMTRP66 | Long             | EC               | CORP              | US        |     11748 | NS      | $224504.28    | 0.40%             |  |  |  | No            |                  1 | On Loan: No      |
| NGM Biopharmaceuticals Inc             | NGM Biopharmaceuticals, Inc.                                 | CUSIP: 62921N105<br>LEI: 5493008V5DSDZIGQOP17 | Long             | EC               | CORP              | US        |     14604 | NS      | $73312.08     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Bluebird Bio Inc                       | Bluebird Bio, Inc.                                           | CUSIP: 09609G100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     13410 | NS      | $92797.20     | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Apellis Pharmaceuticals Inc            | Apellis Pharmaceuticals, Inc.                                | CUSIP: 03753U106<br>LEI: 254900HS0ZFRXXSB9D42 | Long             | EC               | CORP              | US        |     16076 | NS      | $831289.96    | 1.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Madrigal Pharmaceuticals Inc           | Madrigal Pharmaceuticals, Inc.                               | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |      2656 | NS      | $770904.00    | 1.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Inspire Medical Systems Inc            | Inspire Medical Systems, Inc.                                | CUSIP: 457730109<br>LEI: 549300XQQCQ7HCJKTW25 | Long             | EC               | CORP              | US        |      4209 | NS      | $1060162.92   | 1.91%             |  |  |  | No            |                  1 | On Loan: No      |
| Arbutus Biopharma Corp                 | Arbutus Biopharma Corp.                                      | CUSIP: 03879J100<br>LEI: 25490064CESONAUIAS23 | Long             | EC               | CORP              | CA        |     28201 | NS      | $65708.33     | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Albireo Pharma Inc                     | Albireo Pharma, Inc.                                         | CUSIP: 01345P106<br>LEI: 549300835H8LC7O8VC29 | Long             | EC               | CORP              | US        |      3544 | NS      | $76585.84     | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| ACADIA Pharmaceuticals Inc             | ACADIA Pharmaceuticals, Inc.                                 | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |     24030 | NS      | $382557.60    | 0.69%             |  |  |  | No            |                  1 | On Loan: No      |
| Cullinan Oncology Inc                  | Cullinan Oncology, Inc.                                      | CUSIP: 230031106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7682 | NS      | $81045.10     | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| CTI BioPharma Corp                     | CTI BioPharma Corp.                                          | CUSIP: 12648L601<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     20292 | NS      | $121954.92    | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| ANI Pharmaceuticals Inc                | ANI Pharmaceuticals, Inc.                                    | CUSIP: 00182C103<br>LEI: 5493000T6CXTND40YH31 | Long             | EC               | CORP              | US        |      2886 | NS      | $116103.78    | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| REVOLUTION Medicines Inc               | REVOLUTION Medicines, Inc.                                   | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |     13301 | NS      | $316829.82    | 0.57%             |  |  |  | No            |                  1 | On Loan: No      |
| Celularity Inc                         | Celularity, Inc.                                             | CUSIP: 151190105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     26869 | NS      | $34661.01     | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| OrthoPediatrics Corp                   | OrthoPediatrics Corp.                                        | CUSIP: 68752L100<br>LEI: 5493000KUTPFGOPAT717 | Long             | EC               | CORP              | US        |      3219 | NS      | $127890.87    | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Biohaven Ltd                           | Biohaven Ltd.                                                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | VG        |      6642 | NS      | $92190.96     | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Iovance Biotherapeutics Inc            | Iovance Biotherapeutics, Inc.                                | CUSIP: 462260100<br>LEI: 549300220Z2GHH33XL82 | Long             | EC               | CORP              | US        |     24099 | NS      | $153992.61    | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Nevro Corp                             | Nevro Corp.                                                  | CUSIP: 64157F103<br>LEI: 254900SH91I4BOYKUE38 | Long             | EC               | CORP              | US        |      5412 | NS      | $214315.20    | 0.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Alphatec Holdings Inc                  | Alphatec Holdings, Inc.                                      | CUSIP: 02081G201<br>LEI: 549300EZE8CQ8K65FS24 | Long             | EC               | CORP              | US        |     16360 | NS      | $202046.00    | 0.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Mersana Therapeutics Inc               | Mersana Therapeutics, Inc.                                   | CUSIP: 59045L106<br>LEI: 529900VWD5VDZ7PVOS22 | Long             | EC               | CORP              | US        |     15873 | NS      | $93015.78     | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Recursion Pharmaceuticals Inc          | Recursion Pharmaceuticals, Inc.                              | CUSIP: 75629V104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     24886 | NS      | $191871.06    | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Celldex Therapeutics Inc               | Celldex Therapeutics, Inc.                                   | CUSIP: 15117B202<br>LEI: 529900F018DMYWH38923 | Long             | EC               | CORP              | US        |      7133 | NS      | $317917.81    | 0.57%             |  |  |  | No            |                  1 | On Loan: No      |
| Cassava Sciences Inc                   | Cassava Sciences, Inc.                                       | CUSIP: 14817C107<br>LEI: 529900XA0UG5JXABYF08 | Long             | EC               | CORP              | US        |      6138 | NS      | $181316.52    | 0.33%             |  |  |  | No            |                  1 | On Loan: —       |
| Amneal Pharmaceuticals Inc             | Amneal Pharmaceuticals, Inc.                                 | CUSIP: 03168L105<br>LEI: 549300VV176ZO5WQHZ61 | Long             | EC               | CORP              | US        |     28785 | NS      | $57282.15     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| ImmunoGen Inc                          | ImmunoGen, Inc.                                              | CUSIP: 45253H101<br>LEI: 54930084U0R1OP766Y02 | Long             | EC               | CORP              | US        |     33871 | NS      | $168000.16    | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Provention Bio Inc                     | Provention Bio, Inc.                                         | CUSIP: 74374N102<br>LEI: 5493003LM26XAVJKLD34 | Long             | EC               | CORP              | US        |     14023 | NS      | $148223.11    | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| AngioDynamics Inc                      | AngioDynamics, Inc.                                          | CUSIP: 03475V101<br>LEI: 549300W3VKC5ZKMO8C28 | Long             | EC               | CORP              | US        |      6771 | NS      | $93236.67     | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Twist Bioscience Corp                  | Twist Bioscience Corp.                                       | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |      8541 | NS      | $203361.21    | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Enanta Pharmaceuticals Inc             | Enanta Pharmaceuticals, Inc.                                 | CUSIP: 29251M106<br>LEI: 529900SSN4DODDQSN594 | Long             | EC               | CORP              | US        |      3269 | NS      | $152073.88    | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| Bioxcel Therapeutics Inc               | Bioxcel Therapeutics, Inc.                                   | CUSIP: 09075P105<br>LEI: 549300Y25FYZ0E8LW260 | Long             | EC               | CORP              | US        |      5358 | NS      | $115089.84    | 0.21%             |  |  |  | No            |                  1 | On Loan: —       |
| Denali Therapeutics Inc                | Denali Therapeutics, Inc.                                    | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |     19875 | NS      | $552723.75    | 0.99%             |  |  |  | No            |                  1 | On Loan: No      |
| Sutro Biopharma Inc                    | Sutro Biopharma, Inc.                                        | CUSIP: 869367102<br>LEI: 5493005U6P15VD25P851 | Long             | EC               | CORP              | US        |      9987 | NS      | $80694.96     | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Kiniksa Pharmaceuticals Ltd            | Kiniksa Pharmaceuticals Ltd.                                 | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | BM        |      6067 | NS      | $90883.66     | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytek Biosciences Inc                  | Cytek Biosciences, Inc.                                      | CUSIP: 23285D109<br>LEI: 549300K2J28BOC6FBO89 | Long             | EC               | CORP              | US        |     20189 | NS      | $206129.69    | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Mirati Therapeutics Inc                | Mirati Therapeutics, Inc.                                    | CUSIP: 60468T105<br>LEI: 529900GYRW59IDQV6N54 | Long             | EC               | CORP              | US        |      8252 | NS      | $373898.12    | 0.67%             |  |  |  | No            |                  1 | On Loan: No      |
| Nkarta Inc                             | Nkarta, Inc.                                                 | CUSIP: 65487U108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8072 | NS      | $48351.28     | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Sana Biotechnology Inc                 | Sana Biotechnology, Inc.                                     | CUSIP: 799566104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     29752 | NS      | $117520.40    | 0.21%             |  |  |  | No            |                  1 | On Loan: —       |
| SomaLogic Inc                          | SomaLogic, Inc.                                              | CUSIP: 83444K105<br>LEI: 549300D3W3Q8CN30YO25 | Long             | EC               | CORP              | US        |     31284 | NS      | $78522.84     | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Cara Therapeutics Inc                  | Cara Therapeutics, Inc.                                      | CUSIP: 140755109<br>LEI: 549300COVOY41P0GZ881 | Long             | EC               | CORP              | US        |      9149 | NS      | $98260.26     | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Akero Therapeutics Inc                 | Akero Therapeutics, Inc.                                     | CUSIP: 00973Y108<br>LEI: 549300SI3KG74LBE2955 | Long             | EC               | CORP              | US        |      6969 | NS      | $381901.20    | 0.69%             |  |  |  | No            |                  1 | On Loan: No      |
| Cerevel Therapeutics Holdings Inc      | Cerevel Therapeutics Holdings, Inc.                          | CUSIP: 15678U128<br>LEI: 254900RJNIRS9COSQR41 | Long             | EC               | CORP              | US        |     23016 | NS      | $725924.64    | 1.31%             |  |  |  | No            |                  1 | On Loan: No      |
| TransMedics Group Inc                  | TransMedics Group, Inc.                                      | CUSIP: 89377M109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4787 | NS      | $295453.64    | 0.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Inovio Pharmaceuticals Inc             | Inovio Pharmaceuticals, Inc.                                 | CUSIP: 45773H201<br>LEI: 529900B9W875XDZXTM97 | Long             | EC               | CORP              | US        |     43715 | NS      | $68195.40     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Tarsus Pharmaceuticals Inc             | Tarsus Pharmaceuticals, Inc.                                 | CUSIP: 87650L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4701 | NS      | $68916.66     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Axsome Therapeutics Inc                | Axsome Therapeutics, Inc.                                    | CUSIP: 05464T104<br>LEI: 549300EXGR0XLRJEIB95 | Long             | EC               | CORP              | US        |      6483 | NS      | $500033.79    | 0.90%             |  |  |  | No            |                  1 | On Loan: No      |
| Akoya Biosciences Inc                  | Akoya Biosciences, Inc.                                      | CUSIP: 00974H104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6516 | NS      | $62358.12     | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| ImmunityBio Inc                        | ImmunityBio, Inc.                                            | CUSIP: 45256X103<br>LEI: 529900J9XLBR4HFL4B83 | Long             | EC               | CORP              | US        |     59901 | NS      | $303698.07    | 0.55%             |  |  |  | No            |                  1 | On Loan: —       |
| Vaxart Inc                             | Vaxart, Inc.                                                 | CUSIP: 92243A200<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     26634 | NS      | $25592.61     | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Intra-Cellular Therapies Inc           | Intra-Cellular Therapies, Inc.                               | CUSIP: 46116X101<br>LEI: 5299002U2KGF193IJA20 | Long             | EC               | CORP              | US        |     13923 | NS      | $736805.16    | 1.32%             |  |  |  | No            |                  1 | On Loan: No      |
| Quantum-Si Inc                         | Quantum-Si, Inc.                                             | CUSIP: 74765K105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     22459 | NS      | $41099.97     | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Pulmonx Corp                           | Pulmonx Corp.                                                | CUSIP: 745848101<br>LEI: 549300WZMFR0ZK7RJY40 | Long             | EC               | CORP              | US        |      6311 | NS      | $53201.73     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Perrigo Co PLC                         | Perrigo Co. PLC                                              | CUSIP: 000000000<br>LEI: 549300IFOQS6R1QLY196 | Long             | EC               | CORP              | IE        |     19781 | NS      | $674334.29    | 1.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvation Bio Inc                       | Nuvation Bio, Inc.                                           | CUSIP: 67080N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     37692 | NS      | $72368.64     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Krystal Biotech Inc                    | Krystal Biotech, Inc.                                        | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |      3873 | NS      | $306819.06    | 0.55%             |  |  |  | No            |                  1 | On Loan: No      |
| Reata Pharmaceuticals Inc              | Reata Pharmaceuticals, Inc.                                  | CUSIP: 75615P103<br>LEI: 5299005F094GH9QDDD80 | Long             | EC               | CORP              | US        |      5112 | NS      | $194204.88    | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Amylyx Pharmaceuticals Inc             | Amylyx Pharmaceuticals, Inc.                                 | CUSIP: 03237H101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      9715 | NS      | $358969.25    | 0.65%             |  |  |  | No            |                  1 | On Loan: No      |
| ADMA Biologics Inc                     | ADMA Biologics, Inc.                                         | CUSIP: 000899104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     33393 | NS      | $129564.84    | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Fate Therapeutics Inc                  | Fate Therapeutics, Inc.                                      | CUSIP: 31189P102<br>LEI: 549300L14Q4UHOODLA90 | Long             | EC               | CORP              | US        |     14603 | NS      | $147344.27    | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Tricida Inc                            | Tricida, Inc.                                                | CUSIP: 89610F101<br>LEI: 549300QVPFFJC8SZXG25 | Long             | EC               | CORP              | US        |      9656 | NS      | $1476.40      | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Ideaya Biosciences Inc                 | Ideaya Biosciences, Inc.                                     | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |      7574 | NS      | $137619.58    | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Butterfly Network Inc                  | Butterfly Network, Inc.                                      | CUSIP: 124155102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     27966 | NS      | $68796.36     | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Karuna Therapeutics Inc                | Karuna Therapeutics, Inc.                                    | CUSIP: 48576A100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4884 | NS      | $959706.00    | 1.73%             |  |  |  | No            |                  1 | On Loan: No      |
| Avidity Biosciences Inc                | Avidity Biosciences, Inc.                                    | CUSIP: 05370A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8568 | NS      | $190123.92    | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Replimune Group Inc                    | Replimune Group, Inc.                                        | CUSIP: 76029N106<br>LEI: 549300AY704NEIRC4K64 | Long             | EC               | CORP              | US        |      7792 | NS      | $211942.40    | 0.38%             |  |  |  | No            |                  1 | On Loan: No      |
| NanoString Technologies Inc            | NanoString Technologies, Inc.                                | CUSIP: 63009R109<br>LEI: 549300G4CK0Y3WRDMY89 | Long             | EC               | CORP              | US        |      8180 | NS      | $65194.60     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Liquidia Corp                          | Liquidia Corp.                                               | CUSIP: 53635D202<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     12469 | NS      | $79427.53     | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| IGM Biosciences Inc                    | IGM Biosciences, Inc.                                        | CUSIP: 449585108<br>LEI: 5493008XCQES2N0VY969 | Long             | EC               | CORP              | US        |      4876 | NS      | $82940.76     | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| DICE Therapeutics Inc                  | DICE Therapeutics, Inc.                                      | CUSIP: 23345J104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7034 | NS      | $219460.80    | 0.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Veracyte Inc                           | Veracyte, Inc.                                               | CUSIP: 92337F107<br>LEI: 529900ESWZRHXOW27Z37 | Long             | EC               | CORP              | US        |     11132 | NS      | $264162.36    | 0.48%             |  |  |  | No            |                  1 | On Loan: No      |
| Atea Pharmaceuticals Inc               | Atea Pharmaceuticals, Inc.                                   | CUSIP: 04683R106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     14584 | NS      | $70149.04     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Vaxcyte Inc                            | Vaxcyte, Inc.                                                | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |      9850 | NS      | $472307.50    | 0.85%             |  |  |  | No            |                  1 | On Loan: No      |
| ViewRay Inc                            | ViewRay, Inc.                                                | CUSIP: 92672L107<br>LEI: 5493006XTUBSKFU3W106 | Long             | EC               | CORP              | US        |     29504 | NS      | $132177.92    | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Quanterix Corp                         | Quanterix Corp.                                              | CUSIP: 74766Q101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6835 | NS      | $94664.75     | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Aadi Bioscience Inc                    | Aadi Bioscience, Inc.                                        | CUSIP: 00032Q104<br>LEI: 549300G3U7TKW1M58L09 | Long             | EC               | CORP              | US        |      4119 | NS      | $52846.77     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Sorrento Therapeutics Inc              | Sorrento Therapeutics, Inc.                                  | CUSIP: 83587F202<br>LEI: 549300RH23PRR3M13410 | Long             | EC               | CORP              | US        |     73704 | NS      | $65301.74     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Blueprint Medicines Corp               | Blueprint Medicines Corp.                                    | CUSIP: 09627Y109<br>LEI: 5299004CC60O9T5HVM83 | Long             | EC               | CORP              | US        |      8823 | NS      | $386535.63    | 0.70%             |  |  |  | No            |                  1 | On Loan: No      |
| Invivyd Inc                            | Invivyd, Inc.                                                | CUSIP: 00534A102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     19592 | NS      | $29388.00     | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Morphic Holding Inc                    | Morphic Holding, Inc.                                        | CUSIP: 61775R105<br>LEI: 549300RWWOUFLHTY1224 | Long             | EC               | CORP              | US        |      6076 | NS      | $162533.00    | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Rigel Pharmaceuticals Inc              | Rigel Pharmaceuticals, Inc.                                  | CUSIP: 766559603<br>LEI: 529900KPTNUS5J8K9K66 | Long             | EC               | CORP              | US        |     42502 | NS      | $63753.00     | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Imago Biosciences Inc                  | Imago Biosciences, Inc.                                      | CUSIP: 45250K107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5783 | NS      | $207898.85    | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| CareDx Inc                             | CareDx, Inc.                                                 | CUSIP: 14167L103<br>LEI: 549300NQOFKL9NON0U06 | Long             | EC               | CORP              | US        |      8484 | NS      | $96802.44     | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Bridgebio Pharma Inc                   | Bridgebio Pharma, Inc.                                       | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |     22556 | NS      | $171876.72    | 0.31%             |  |  |  | No            |                  1 | On Loan: No      |
| Prothena Corp PLC                      | Prothena Corp. PLC                                           | CUSIP: 000000000<br>LEI: 5299009ZXQ8NIIJ8OL30 | Long             | EC               | CORP              | IE        |      6952 | NS      | $418858.00    | 0.75%             |  |  |  | No            |                  1 | On Loan: No      |
| Heska Corp                             | Heska Corp.                                                  | CUSIP: 42805E306<br>LEI: 529900O1OR2EB7L0HY27 | Long             | EC               | CORP              | US        |      1747 | NS      | $108593.52    | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Kodiak Sciences Inc                    | Kodiak Sciences, Inc.                                        | CUSIP: 50015M109<br>LEI: 254900IXI5NI8C9OQE24 | Long             | EC               | CORP              | US        |      9510 | NS      | $68091.60     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvalent Inc                           | Nuvalent, Inc.                                               | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6860 | NS      | $204290.80    | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Kinnate Biopharma Inc                  | Kinnate Biopharma, Inc.                                      | CUSIP: 49705R105<br>LEI: 549300YVIWV7HJ5WHI66 | Long             | EC               | CORP              | US        |      8213 | NS      | $50099.30     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| MacroGenics Inc                        | MacroGenics, Inc.                                            | CUSIP: 556099109<br>LEI: 5493001KJQUA83L8MH79 | Long             | EC               | CORP              | US        |     11759 | NS      | $78902.89     | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Kymera Therapeutics Inc                | Kymera Therapeutics, Inc.                                    | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8389 | NS      | $209389.44    | 0.38%             |  |  |  | No            |                  1 | On Loan: No      |
| Stoke Therapeutics Inc                 | Stoke Therapeutics, Inc.                                     | CUSIP: 86150R107<br>LEI: 549300RD25SS2DIJHJ67 | Long             | EC               | CORP              | US        |      6680 | NS      | $61656.40     | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Zimvie Inc                             | Zimvie, Inc.                                                 | CUSIP: 98888T107<br>LEI: 549300GFKURT1J6XR665 | Long             | EC               | CORP              | US        |      5747 | NS      | $53676.98     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Seer Inc                               | Seer, Inc.                                                   | CUSIP: 81578P106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     10508 | NS      | $60946.40     | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Deciphera Pharmaceuticals Inc          | Deciphera Pharmaceuticals, Inc.                              | CUSIP: 24344T101<br>LEI: 529900QR4WAPYY0CBF25 | Long             | EC               | CORP              | US        |     10396 | NS      | $170390.44    | 0.31%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcellx Inc                            | Arcellx, Inc.                                                | CUSIP: 03940C100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6981 | NS      | $216271.38    | 0.39%             |  |  |  | No            |                  1 | On Loan: No      |
| IVERIC bio Inc                         | IVERIC bio, Inc.                                             | CUSIP: 46583P102<br>LEI: 549300GZXI59U71XPM70 | Long             | EC               | CORP              | US        |     17542 | NS      | $375574.22    | 0.68%             |  |  |  | No            |                  1 | On Loan: No      |
| TG Therapeutics Inc                    | TG Therapeutics, Inc.                                        | CUSIP: 88322Q108<br>LEI: 529900X21UKABN9NJ529 | Long             | EC               | CORP              | US        |     23504 | NS      | $278052.32    | 0.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Edgewise Therapeutics Inc              | Edgewise Therapeutics, Inc.                                  | CUSIP: 28036F105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8500 | NS      | $75990.00     | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Sarepta Therapeutics Inc               | Sarepta Therapeutics, Inc.                                   | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |     12731 | NS      | $1649682.98   | 2.97%             |  |  |  | No            |                  1 | On Loan: No      |
| FibroGen Inc                           | FibroGen, Inc.                                               | CUSIP: 31572Q808<br>LEI: 549300Q914ULWWY95822 | Long             | EC               | CORP              | US        |     14267 | NS      | $228557.34    | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Gossamer Bio Inc                       | Gossamer Bio, Inc.                                           | CUSIP: 38341P102<br>LEI: 549300ZOC0N2W6PSFR58 | Long             | EC               | CORP              | US        |     14896 | NS      | $32324.32     | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Sangamo Therapeutics Inc               | Sangamo Therapeutics, Inc.                                   | CUSIP: 800677106<br>LEI: 2549006WMRKRC4G32Z67 | Long             | EC               | CORP              | US        |     25681 | NS      | $80638.34     | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Heron Therapeutics Inc                 | Heron Therapeutics, Inc.                                     | CUSIP: 427746102<br>LEI: 549300DR2I1DOPD2IX53 | Long             | EC               | CORP              | US        |     20637 | NS      | $51592.50     | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| NeoGenomics Inc                        | NeoGenomics, Inc.                                            | CUSIP: 64049M209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     20332 | NS      | $187867.68    | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| OMNIAB INC                             | OmniAb, Inc.                                                 | CUSIP: 68218J202<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       977 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  2 | On Loan: No      |
| Ultragenyx Pharmaceutical Inc          | Ultragenyx Pharmaceutical, Inc.                              | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |     10379 | NS      | $480859.07    | 0.86%             |  |  |  | No            |                  1 | On Loan: No      |
| Ventyx Biosciences Inc                 | Ventyx Biosciences, Inc.                                     | CUSIP: 92332V107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8592 | NS      | $281731.68    | 0.51%             |  |  |  | No            |                  1 | On Loan: No      |
| Insmed Inc                             | Insmed, Inc.                                                 | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |     20278 | NS      | $405154.44    | 0.73%             |  |  |  | No            |                  1 | On Loan: No      |
| Nano-X Imaging Ltd                     | Nano-X Imaging Ltd.                                          | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | IL        |      8675 | NS      | $64021.50     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| RAPT Therapeutics Inc                  | RAPT Therapeutics, Inc.                                      | CUSIP: 75382E109<br>LEI: 549300MB473BIU78ES48 | Long             | EC               | CORP              | US        |      4908 | NS      | $97178.40     | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcus Biosciences Inc                  | Arcus Biosciences, Inc.                                      | CUSIP: 03969F109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     10812 | NS      | $223592.16    | 0.40%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcutis Biotherapeutics Inc            | Arcutis Biotherapeutics, Inc.                                | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      9418 | NS      | $139386.40    | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Orthofix Medical Inc                   | Orthofix Medical, Inc.                                       | CUSIP: 68752M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3848 | NS      | $78999.44     | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Design Therapeutics Inc                | Design Therapeutics, Inc.                                    | CUSIP: 25056L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8889 | NS      | $91201.14     | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Vericel Corp                           | Vericel Corp.                                                | CUSIP: 92346J108<br>LEI: 54930076YM3PLTDR4B91 | Long             | EC               | CORP              | US        |      7318 | NS      | $192756.12    | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Silk Road Medical Inc                  | Silk Road Medical, Inc.                                      | CUSIP: 82710M100<br>LEI: 549300VL8KC0ZPDQHE14 | Long             | EC               | CORP              | US        |      5705 | NS      | $301509.25    | 0.54%             |  |  |  | No            |                  1 | On Loan: No      |
| Principal Government Money Market Fund | Principal Government Money Market Fund                       | CUSIP: 000000000<br>LEI: 549300WWK3YB7DNN4U34 | Long             | STIV             | RF                | US        |   1061503 | NS      | $1061503.25   | 1.91%             |  |  |  | No            |                  1 | On Loan: No      |
| Arvinas Inc                            | Arvinas, Inc.                                                | CUSIP: 04335A105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7929 | NS      | $271251.09    | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Cogent Biosciences Inc                 | Cogent Biosciences, Inc.                                     | CUSIP: 19240Q201<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     10417 | NS      | $120420.52    | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| ALX Oncology Holdings Inc              | ALX Oncology Holdings, Inc.                                  | CUSIP: 00166B105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7043 | NS      | $79374.61     | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Emergent BioSolutions Inc              | Emergent BioSolutions, Inc.                                  | CUSIP: 29089Q105<br>LEI: 549300YW6TUOX8BE5103 | Long             | EC               | CORP              | US        |      7902 | NS      | $93322.62     | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Natera Inc                             | Natera, Inc.                                                 | CUSIP: 632307104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     14333 | NS      | $575756.61    | 1.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Affimed NV                             | Affimed NV                                                   | CUSIP: 000000000<br>LEI: 5493004V4FSXT1D04610 | Long             | EC               | CORP              | NL        |     29463 | NS      | $36534.12     | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Editas Medicine Inc                    | Editas Medicine, Inc.                                        | CUSIP: 28106W103<br>LEI: 5299000AON4Q9NT2JE42 | Long             | EC               | CORP              | US        |     11039 | NS      | $97915.93     | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Crinetics Pharmaceuticals Inc          | Crinetics Pharmaceuticals, Inc.                              | CUSIP: 22663K107<br>LEI: 549300Q1CNFXK5P31D28 | Long             | EC               | CORP              | US        |      8505 | NS      | $155641.50    | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Bionano Genomics Inc                   | Bionano Genomics, Inc.                                       | CUSIP: 09075F107<br>LEI: 54930086AP7ROH0VJ631 | Long             | EC               | CORP              | US        |     48142 | NS      | $70287.32     | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| VistaGen Therapeutics Inc              | VistaGen Therapeutics, Inc.                                  | CUSIP: 92840H202<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    165962 | NS      | $17094.09     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Bio-Rad Laboratories Inc               | Bio-Rad Laboratories, Inc.                                   | CUSIP: 090572207<br>LEI: 549300ZC1GPV35XYDK53 | Long             | EC               | CORP              | US        |      4291 | NS      | $1804322.59   | 3.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Outset Medical Inc                     | Outset Medical, Inc.                                         | CUSIP: 690145107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7839 | NS      | $202402.98    | 0.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytokinetics Inc                       | Cytokinetics, Inc.                                           | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |     14172 | NS      | $649361.04    | 1.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Chimerix Inc                           | Chimerix, Inc.                                               | CUSIP: 16934W106<br>LEI: 5299002IR2GXUBEPKS66 | Long             | EC               | CORP              | US        |     20828 | NS      | $38740.08     | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Inhibrx Inc                            | Inhibrx, Inc.                                                | CUSIP: 45720L107<br>LEI: 549300VBKG2LTV1TLY22 | Long             | EC               | CORP              | US        |      6042 | NS      | $148874.88    | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| Ocular Therapeutix Inc                 | Ocular Therapeutix, Inc.                                     | CUSIP: 67576A100<br>LEI: 529900ABAWFXOHSIHG03 | Long             | EC               | CORP              | US        |     15240 | NS      | $42824.40     | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Inotiv Inc                             | Inotiv, Inc.                                                 | CUSIP: 45783Q100<br>LEI: 549300FH5Z13X0Q5SK81 | Long             | EC               | CORP              | US        |      4397 | NS      | $21721.18     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Nurix Therapeutics Inc                 | Nurix Therapeutics, Inc.                                     | CUSIP: 67080M103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7994 | NS      | $87774.12     | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Syndax Pharmaceuticals Inc             | Syndax Pharmaceuticals, Inc.                                 | CUSIP: 87164F105<br>LEI: 529900OF94TRHKZVBS87 | Long             | EC               | CORP              | US        |      8690 | NS      | $221160.50    | 0.40%             |  |  |  | No            |                  1 | On Loan: No      |
| REGENXBIO Inc                          | REGENXBIO, Inc.                                              | CUSIP: 75901B107<br>LEI: 549300EOES47LATSET33 | Long             | EC               | CORP              | US        |      6792 | NS      | $154042.56    | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Immunovant Inc                         | Immunovant, Inc.                                             | CUSIP: 45258J102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     19860 | NS      | $352515.00    | 0.63%             |  |  |  | No            |                  1 | On Loan: No      |
| Glaukos Corp                           | Glaukos Corp.                                                | CUSIP: 377322102<br>LEI: 5299004JA1LHE21M6T14 | Long             | EC               | CORP              | US        |      7062 | NS      | $308468.16    | 0.55%             |  |  |  | No            |                  1 | On Loan: No      |
| Day One Biopharmaceuticals Inc         | Day One Biopharmaceuticals, Inc.                             | CUSIP: 23954D109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     11230 | NS      | $241669.60    | 0.43%             |  |  |  | No            |                  1 | On Loan: No      |
| Cerus Corp                             | Cerus Corp.                                                  | CUSIP: 157085101<br>LEI: 254900BIEY9XIDA04Q21 | Long             | EC               | CORP              | US        |     29356 | NS      | $107149.40    | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Rocket Pharmaceuticals Inc             | Rocket Pharmaceuticals, Inc.                                 | CUSIP: 77313F106<br>LEI: 549300R7VV82YUIN4Y93 | Long             | EC               | CORP              | US        |     10252 | NS      | $200631.64    | 0.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Atara Biotherapeutics Inc              | Atara Biotherapeutics, Inc.                                  | CUSIP: 046513107<br>LEI: 549300WBXUXZRE03MS38 | Long             | EC               | CORP              | US        |     16863 | NS      | $55310.64     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| EQRx Inc                               | EQRx, Inc.                                                   | CUSIP: 26886C107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     67018 | NS      | $164864.28    | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Artivion Inc                           | Artivion, Inc.                                               | CUSIP: 228903100<br>LEI: 549300YTKV8DMSMG6K81 | Long             | EC               | CORP              | US        |      7355 | NS      | $89142.60     | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Coherus Biosciences Inc                | Coherus Biosciences, Inc.                                    | CUSIP: 19249H103<br>LEI: 5493007IL8W5MV932D26 | Long             | EC               | CORP              | US        |     12795 | NS      | $101336.40    | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Aurinia Pharmaceuticals Inc            | Aurinia Pharmaceuticals, Inc.                                | CUSIP: 05156V102<br>LEI: 5299008YP2BW4570ML28 | Long             | EC               | CORP              | CA        |     25261 | NS      | $109127.52    | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Alkermes PLC                           | Alkermes PLC                                                 | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | IE        |     24360 | NS      | $636526.80    | 1.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Elanco Animal Health Inc               | Elanco Animal Health, Inc.                                   | CUSIP: 28414H103<br>LEI: 549300SHPNDCE059M934 | Long             | EC               | CORP              | US        |     69526 | NS      | $849607.72    | 1.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Amicus Therapeutics Inc                | Amicus Therapeutics, Inc.                                    | CUSIP: 03152W109<br>LEI: 549300MRD1SMUTNBPQ53 | Long             | EC               | CORP              | US        |     41374 | NS      | $505176.54    | 0.91%             |  |  |  | No            |                  1 | On Loan: No      |
| Codexis Inc                            | Codexis, Inc.                                                | CUSIP: 192005106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     12150 | NS      | $56619.00     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| PROCEPT BioRobotics Corp               | PROCEPT BioRobotics Corp.                                    | CUSIP: 74276L105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6709 | NS      | $278691.86    | 0.50%             |  |  |  | No            |                  1 | On Loan: No      |
| SIGA Technologies Inc                  | SIGA Technologies, Inc.                                      | CUSIP: 826917106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     12033 | NS      | $88562.88     | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| C4 Therapeutics Inc                    | C4 Therapeutics, Inc.                                        | CUSIP: 12529R107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8630 | NS      | $50917.00     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC Therapeutics Inc                   | PTC Therapeutics, Inc.                                       | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |     10531 | NS      | $401968.27    | 0.72%             |  |  |  | No            |                  1 | On Loan: No      |
| CryoPort Inc                           | CryoPort, Inc.                                               | CUSIP: 229050307<br>LEI: 9845004D8538BT8JF626 | Long             | EC               | CORP              | US        |      7513 | NS      | $130350.55    | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Novavax Inc                            | Novavax, Inc.                                                | CUSIP: 670002401<br>LEI: 529900J4GJHPEPQ23205 | Long             | EC               | CORP              | US        |     11917 | NS      | $122506.76    | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Evolus Inc                             | Evolus, Inc.                                                 | CUSIP: 30052C107<br>LEI: 549300VYQRYBQOT8V419 | Long             | EC               | CORP              | US        |      9676 | NS      | $72666.76     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Eiger BioPharmaceuticals Inc           | Eiger BioPharmaceuticals, Inc.                               | CUSIP: 28249U105<br>LEI: 549300GO4VMIHDKJNU46 | Long             | EC               | CORP              | US        |      9133 | NS      | $10776.94     | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Karyopharm Therapeutics Inc            | Karyopharm Therapeutics, Inc.                                | CUSIP: 48576U106<br>LEI: 549300J1VANRCNTYST87 | Long             | EC               | CORP              | US        |     14545 | NS      | $49453.00     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| SpringWorks Therapeutics Inc           | SpringWorks Therapeutics, Inc.                               | CUSIP: 85205L107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      9502 | NS      | $247147.02    | 0.44%             |  |  |  | No            |                  1 | On Loan: No      |
| 4D Molecular Therapeutics Inc          | 4D Molecular Therapeutics, Inc.                              | CUSIP: 35104E100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6955 | NS      | $154470.55    | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| MaxCyte Inc                            | MaxCyte, Inc.                                                | CUSIP: 57777K106<br>LEI: 54930053YHXULRFCU991 | Long             | EC               | CORP              | US        |     16923 | NS      | $92399.58     | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Mirum Pharmaceuticals Inc              | Mirum Pharmaceuticals, Inc.                                  | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |      5996 | NS      | $116922.00    | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| State Street Global Advisors           | State Street Institutional U.S. Government Money Market Fund | CUSIP: 857492706<br>LEI: 549300BZ5TGIFZUZDZ37 | Long             | STIV             | RF                | US        |    118129 | NS      | $118128.95    | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Fulcrum Therapeutics Inc               | Fulcrum Therapeutics, Inc.                                   | CUSIP: 359616109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     10008 | NS      | $72858.24     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Xencor Inc                             | Xencor, Inc.                                                 | CUSIP: 98401F105<br>LEI: 549300V5IF65437JKG30 | Long             | EC               | CORP              | US        |      9041 | NS      | $235427.64    | 0.42%             |  |  |  | No            |                  1 | On Loan: No      |
| Allogene Therapeutics Inc              | Allogene Therapeutics, Inc.                                  | CUSIP: 019770106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     21972 | NS      | $138203.88    | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Agenus Inc                             | Agenus, Inc.                                                 | CUSIP: 00847G705<br>LEI: 529900NDQQGU5H4UJK81 | Long             | EC               | CORP              | US        |     45880 | NS      | $110112.00    | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| MannKind Corp                          | MannKind Corp.                                               | CUSIP: 56400P706<br>LEI: 213800GFBCNY1ZFST722 | Long             | EC               | CORP              | US        |     41068 | NS      | $216428.36    | 0.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Zentalis Pharmaceuticals Inc           | Zentalis Pharmaceuticals, Inc.                               | CUSIP: 98943L107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8782 | NS      | $176869.48    | 0.32%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2023-01-19

**Name of Applicant:** Principal Exchange-Traded Funds

**Signature:** Megan Hoffmann

**Name of Signer:** Megan Hoffmann

**Title:** Vice President and Controller