# EDGAR Filing Document

**Accession Number:** 0001656634
**File Stem:** 0001193125-23-066286
**Filing Date:** 2023-3
**Character Count:** 22620
**Document Hash:** f8e9e7b7196f4e93b16cfd4d0ff0d5f5
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-23-066286.hdr.sgml**: 20230309

**ACCESSION NUMBER**: 0001193125-23-066286

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 6

**FILED AS OF DATE**: 20230309

**DATE AS OF CHANGE**: 20230309

**EFFECTIVENESS DATE**: 20230309

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Gritstone bio, Inc.
- **CENTRAL INDEX KEY:** 0001656634
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-270429
- **FILM NUMBER:** 23720742

**BUSINESS ADDRESS:**
- **STREET 1:** 5959 HORTON STREET, SUITE 300
- **CITY:** EMERYVILLE
- **STATE:** CA
- **ZIP:** 94608
- **BUSINESS PHONE:** (510) 871-6100

**MAIL ADDRESS:**
- **STREET 1:** 5959 HORTON STREET, SUITE 300
- **CITY:** EMERYVILLE
- **STATE:** CA
- **ZIP:** 94608

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Gritstone Oncology, Inc.
- **DATE OF NAME CHANGE:** 20151023

**As filed with the Securities and Exchange Commission on March 9, 2023** 

**Registration No. 333-** 

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**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**Washington, D.C. 20549** 

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**FORM S-8** 

**REGISTRATION STATEMENT** 

***UNDER***

***THE SECURITIES ACT OF 1933***

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## Gritstone bio, Inc.
**(Exact name of Registrant as specified in its charter)** 

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---

| | |
|:---|:---|
| **Delaware** | **47-4859534** |
| **(State or other jurisdiction of**<br> **incorporation or organization)** | **(I.R.S. Employer**<br> **Identification Number)** |
| **5959 Horton Street, Suite 300**<br> **Emeryville, California 94608** | **94608** |
| **(Address of Principal Executive Offices)** | **(Zip Code)** |

---

**2018 Incentive Award Plan** 

**2018 Employee Stock Purchase Plan** 

**2021 Employment Inducement Incentive Plan** 

**(Full Title of the Plan)** 

**Andrew Allen, M.D., Ph.D.** 

**President and Chief Executive Officer** 

**Gritstone bio, Inc.** 

**5959 Horton Street, Suite 300** 

**Emeryville, California 94608** 

**(510) 871-6100** 

**(Name, address, including zip code, and telephone number, including area code, of agent for service)** 

***Copies to:***

**Brian J. Cuneo, Esq.** 

**Mark V. Roeder, Esq.** 

**Latham & Watkins LLP** 

**140 Scott Drive** 

**Menlo Park, California 94025** 

**Telephone: (650) 328-4600** 

**Facsimile: (650) 463-2600** 

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Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☐ | Accelerated filer | ☐ |
| Non-accelerated filer | ☒ | Smaller reporting company | ☒ |
|  |  | Emerging growth company | ☒ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☒

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**Proposed sale to take place as soon after the effective date of the** 

**registration statement as awards under the plans are exercised and/or vest.** 

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**REGISTRATION OF ADDITIONAL SECURITIES** 

By a registration statement on Form S-8 filed with the Securities and Exchange Commission (the "SEC") on October 2, 2018 (File No. 333-227665) (the "Original Registration Statement"), Gritstone bio, Inc. (the "Registrant") registered 2,782,920 shares of common stock, par value $0.0001 per share (the "Common Stock"), issuable under the Gritstone Oncology, Inc. 2018 Incentive Award Plan (the "2018 Plan"), and 282,334 shares of Common Stock issuable under the Gritstone Oncology, Inc. 2018 Employee Stock Purchase Plan (the "ESPP"). The Original Registration Statement also registered 2,355,270 shares of Common Stock issuable under the Gritstone Oncology, Inc. 2015 Equity Incentive Plan, as amended (the "2015 Plan"), which shares become available for issuance under the 2018 Plan to the extent awards under the 2015 Plan are forfeited or lapse unexercised and are not issued under the 2015 Plan. By a registration statement on Form S-8 filed with the SEC on March 28, 2019 (File No. 333-230581) (the "2019 Registration Statement"), the Registrant registered an additional 1,160,000 shares of Common Stock issuable under the 2018 Plan and an additional 290,000 shares of Common Stock issuable under the ESPP. By a registration statement on Form S-8 filed with the SEC on March 11, 2020 (File No. 333-237095) (the "2020 Registration Statement"), the Registrant registered an additional 1,454,553 shares of Common Stock issuable under the 2018 Plan and an additional 363,638 shares of Common Stock issuable under the ESPP. By a registration statement on Form S-8 filed with the SEC on March 11, 2021 (File No. 333-254177) (the "2021 Registration Statement"), the Registrant registered an additional 1,902,107 shares of Common Stock issuable under the 2018 Plan and an additional 475,526 shares of Common Stock issuable under the ESPP. By a registration statement on Form S-8 filed with the SEC on March 10, 2022 (File No. 333-263451) (the "March 2022 Registration Statement"), the Registrant registered an additional 2,761,915 shares of Common Stock issuable under the 2018 Plan and an additional 690,479 shares of Common Stock issuable under the ESPP. The Registrant is hereby registering an additional 3,475,796 shares of Common Stock issuable under the 2018 Plan and an additional 868,949 shares of Common Stock issuable under the ESPP, which shares are now available for grant due to automatic annual increase provisions in the 2018 Plan and ESPP.

In addition, by a registration statement on Form S-8 filed with the SEC on May 6, 2021 (File No. 333-255847) (the "2021 Original Registration Statement"), the Registrant registered 790,400 shares of Common Stock issuable under the Gritstone bio, Inc. 2021 Employment Inducement Incentive Plan (the "2021 Plan"). By a registration statement on Form S-8 filed with the SEC on May 9, 2022 (File No. 333-264804) (the "May 2022 Registration Statement"), the Registrant registered an additional 700,000 shares of Common Stock issuable under the 2021 Plan. The Registrant is hereby registering an additional 1,300,000 shares of Common Stock issuable under the 2021 Plan, which shares are now available for grant.

**INCORPORATION BY REFERENCE OF CONTENTS OF** 

**REGISTRATION STATEMENT ON FORM S-8** 

Pursuant to Instruction E of Form S-8, the contents of the Original Registration Statement, the 2019 Registration Statement, the 2020 Registration Statement, the 2021 Registration Statement, the March 2022 Registration Statement, the 2021 Original Registration Statement and the May 2022 Registration Statement are incorporated by reference in this registration statement on Form S-8.

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**INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS** 

The information called for in Part I of Form S-8 is not being filed with or included in this Form S-8 (by incorporation by reference or otherwise) in accordance with the rules and regulations of the SEC.

**Item 8. Exhibits.** 

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| **Exhibit** | | **Incorporated by Reference** | **Incorporated by Reference** | **Incorporated by Reference** | |
| **Number** | <br>**Exhibit Description** | **Form** | **Date** | **Number** | **Filed**<br>**Herewith** |
| &nbsp;&nbsp;&nbsp;&nbsp;4.1(a) | [Amended and Restated Certificate of Incorporation.](http://www.sec.gov/Archives/edgar/data/1656634/000119312518290860/d623029dex31.htm) | 8-K | 10-2-18 | 3.1 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;4.2(b) | [Certificate of Amendment to Amended and Restated Certificate of Incorporation](http://www.sec.gov/Archives/edgar/data/1656634/000119312521152379/d403517dex31.htm) | 8-K | 5-6-21 | 3.1 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;4.2 | [Amended and Restated Bylaws.](http://www.sec.gov/Archives/edgar/data/1656634/000119312518290860/d623029dex32.htm) | 8-K | 10-2-18 | 3.2 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;4.3 | [Form of Common Stock Certificate.](http://www.sec.gov/Archives/edgar/data/1656634/000119312518274609/d565416dex42.htm) | S-1/A | 9-17-18 | 4.2 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;5.1 | [Opinion of Latham & Watkins LLP.](d473764dex51.htm) |  |  |  | X |
| 23.1 | [Consent of Independent Registered Public Accounting Firm.](d473764dex231.htm) |  |  |  | X |
| 23.2 | [Consent of Latham & Watkins LLP (included in Exhibit 5.1).](d473764dex51.htm) |  |  |  | X |
| 24.1 | [Power of Attorney. Reference is made to the signature page to the Registration Statement.](#sig) |  |  |  | X |
| 99.1(a)# | [2018 Incentive Award Plan.](http://www.sec.gov/Archives/edgar/data/1656634/000119312518290941/d612395dex992a.htm) | S-8 | 10-2-18 | 99.2(a) |  |
| 99.1(b)# | [Form of Stock Option Grant Notice and Stock Option Agreement under the 2018 Incentive Award Plan.](http://www.sec.gov/Archives/edgar/data/1656634/000119312518274609/d565416dex107b.htm) | S-1 | 9-17-18 | 10.7(b) |  |
| 99.1(c)# | [Form of Restricted Stock Award Grant Notice and Restricted Stock Award Agreement under the 2018 Incentive Award Plan.](http://www.sec.gov/Archives/edgar/data/1656634/000119312518274609/d565416dex107c.htm) | S-1 | 9-17-18 | 10.7(c) |  |
| 99.1(d)# | [Form of Restricted Stock Unit Award Grant Notice and Restricted Stock Unit Award Agreement under the 2018 Incentive Award Plan.](http://www.sec.gov/Archives/edgar/data/1656634/000119312518274609/d565416dex107d.htm) | S-1 | 9-17-18 | 10.7(d) |  |
| 99.2# | [2018 Employee Stock Purchase Plan.](http://www.sec.gov/Archives/edgar/data/1656634/000119312518290941/d612395dex993.htm) | S-8 | 10-2-18 | 99.3 |  |
| 99.3(a)# | [2021 Employment Inducement Incentive Plan.](http://www.sec.gov/Archives/edgar/data/1656634/000119312521153495/d303641dex991.htm) | S-8 | 5-6-21 | 99.1 |  |
| 99.3(b)# | [Form of Stock Option Agreement Under the 2021 Employment Inducement Incentive Plan.](http://www.sec.gov/Archives/edgar/data/1656634/000119312521153495/d303641dex992.htm) | S-8 | 5-6-21 | 99.2 |  |
| 99.3(c)# | [Form of Restricted Stock Unit Award Agreement under the 2021 Employment Inducement Incentive Plan.](http://www.sec.gov/Archives/edgar/data/1656634/000119312521153495/d303641dex993.htm) | S-8 | 5-6-21 | 99.3 |  |
| 99.3(d)# | [Form of Stock Award Agreement under the 2021 Employment Inducement Incentive Plan.](http://www.sec.gov/Archives/edgar/data/1656634/000119312521153495/d303641dex994.htm) | S-8 | 5-6-21 | 99.4 |  |
| 107 | [Filing Fee Table](d473764dexfilingfees.htm) |  |  |  | X |

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# Indicates management contract or compensatory plan.

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**SIGNATURES** 

Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in Emeryville, California, on this 9th day of March, 2023.

---

| | |
|:---|:---|
| **Gritstone bio, Inc.** | **Gritstone bio, Inc.** |
| By: | /s/ Andrew Allen |
|  | Andrew Allen, M.D., Ph.D. |
|  | *President and Chief Executive Officer* |

---

**POWER OF ATTORNEY** 

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below does hereby constitute and appoint Andrew Allen, M.D., Ph.D. and Vassiliki Economides and each of them, with full power of substitution and full power to act without the other, his or her true and lawful attorney-in-fact and agent to act for him or her in his or her name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this registration statement, and to file this registration statement, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in order to effectuate the same as fully, to all intents and purposes, as they or he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statement has been signed by the following persons in the capacities and on the date indicated.

---

| | | |
|:---|:---|:---|
| **Signature** | **Title** | **Date** |
| /s/ Andrew Allen | President, Chief Executive Officer and Director | March 9, 2023 |
| Andrew Allen, M.D., Ph.D. | (Principal Executive Officer) |  |
| /s/ Vassiliki Economides | Chief Financial Officer | March 9, 2023 |
| Vassiliki "Celia" Economides | (Principal Financial Officer) |  |
| /s/ James Cho | Chief Accounting Officer | March 9, 2023 |
| James Cho | (Principal Accounting Officer) |  |
| /s/ Elaine Jones | Chairperson of Our Board of Directors | March 9, 2023 |
| Elaine Jones, Ph.D. |  |  |
| /s/ Clare Fisher | Director | March 9, 2023 |
| Clare Fisher |  |  |
| /s/ Steve Krognes | Director | March 9, 2023 |
| Steve Krognes |  |  |
| /s/ Naiyer A. Rizvi | Director | March 9, 2023 |
| Naiyer A. Rizvi, M.D. |  |  |
| /s/ Lawrence Corey | Director | March 9, 2023 |
| Lawrence Corey, M.D. |  |  |
| /s/ Shefali Agarwal | Director | March 9, 2023 |
| Shefali Agarwal, M.D., M.P.H. |  |  |

---

## Exhibit 5.1

**Exhibit 5.1** 

---

| | | |
|:---|:---|:---|
|  | 140 Scott Drive<br> Menlo Park, California 94025<br> Tel: +1.650.328.4600 Fax: +1.650.463.2600<br> www.lw.com<br>FIRM / AFFILIATE OFFICES | 140 Scott Drive<br> Menlo Park, California 94025<br> Tel: +1.650.328.4600 Fax: +1.650.463.2600<br> www.lw.com<br>FIRM / AFFILIATE OFFICES |
| ![LOGO](g473764dsp07.jpg) | Austin | Milan |
| ![LOGO](g473764dsp07.jpg) | Beijing | Munich |
| ![LOGO](g473764dsp07.jpg) | Boston | New York |
| ![LOGO](g473764dsp07.jpg) | Brussels | Orange County |
| ![LOGO](g473764dsp07.jpg) | Century City | Paris |
| ![LOGO](g473764dsp07.jpg) | Chicago | Riyadh |
| ![LOGO](g473764dsp07.jpg) | Dubai | San Diego |
| March 9, 2023 | Düsseldorf | San Francisco |
|  | Frankfurt | Seoul |
|  | Hamburg | Shanghai |
|  | Hong Kong | Silicon Valley |
|  | Houston | Singapore |
|  | London | Tel Aviv |
|  | Los Angeles | Tokyo |
|  | Madrid | Washington, D.C. |

---

Gritstone bio, Inc.

5959 Horton Street, Suite 300

Emeryville, CA 94608

---

| | |
|:---|:---|
| Re: | Registration Statement on Form S-8; 5,644,745 shares of Common Stock of Gritstone bio, Inc., par value $0.0001 per share  |

---

Ladies and Gentlemen:

We have acted as special counsel to Gritstone bio, Inc., a Delaware corporation (the "***Company***"), in connection with the registration by the Company of an aggregate of 5,644,745 shares of common stock of the Company, par value $0.0001 per share (the "***Shares***"), issuable under the Company's 2018 Incentive Award Plan (the "***2018 Plan***"), 2018 Employee Stock Purchase Plan (the "***ESPP***") and 2021 Employment Inducement Incentive Plan (the "***2021 Plan***" and together with the 2018 Plan and the ESPP, the "***Plans***").

The Shares are included in a registration statement on Form S-8 under the Securities Act of 1933, as amended (the "***Act***"), filed with the Securities and Exchange Commission (the "***Commission***") on March 9, 2023 (the "***Registration Statement***"). This opinion is being furnished in connection with the requirements of Item 601(b)(5) of Regulation S-K under the Act, and no opinion is expressed herein as to any matter pertaining to the contents of the Registration Statement or the related prospectuses, other than as expressly stated herein with respect to the issuance of the Shares.

As such counsel, we have examined such matters of fact and questions of law as we have considered appropriate for purposes of this letter. With your consent, we have relied upon certificates and other assurances of officers of the Company and others as to factual matters without having independently verified such factual matters. We are opining herein as to the General Corporation Law of the State of Delaware (the "***DGCL***"), and we express no opinion with respect to any other laws.

------

 **March 9, 2023** 

**Page 2**![LOGO](g473764g0309021713867.jpg)

Subject to the foregoing and the other matters set forth herein, it is our opinion that, as of the date hereof, when the Shares shall have been duly registered on the books of the transfer agent and registrar therefor in the name or on behalf of the purchasers and have been issued by the Company against payment therefor in the circumstances contemplated by the Plans, assuming in each case that the individual issuances, grants or awards under the Plans are duly authorized by all necessary corporate action and duly issued, granted or awarded and exercised in accordance with the requirements of law and the applicable Plans (and the agreements and awards duly adopted thereunder and in accordance therewith), the issue and sale of the Shares will have been duly authorized by all necessary corporate action of the Company, and the Shares will be validly issued, fully paid and nonassessable. In rendering the foregoing opinion, we have assumed that the Company will comply with all applicable notice requirements regarding uncertificated shares provided in the DGCL.

This opinion is for your benefit in connection with the Registration Statement and may be relied upon by you and by persons entitled to rely upon it pursuant to the applicable provisions of the Act. We consent to your filing this opinion as an exhibit to the Registration Statement. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Act or the rules and regulations of the Commission thereunder.

Very truly yours,

/s/ Latham & Watkins LLP

## Exhibit 23.1

**Exhibit 23.1** 

**Consent of Independent Registered Public Accounting Firm** 

We consent to the incorporation by reference in the Registration Statement (Form S-8) pertaining to the 2018 Incentive Award Plan, 2018 Employee Stock Purchase Plan and 2021 Employment Inducement Incentive Plan of Gritstone bio, Inc. of our report dated March 9, 2023, with respect to the consolidated financial statements of Gritstone bio, Inc. included in its Annual Report (Form 10-K) for the year ended December 31, 2022, filed with the Securities and Exchange Commission

/s/ Ernst & Young LLP

San Mateo, California

March 9, 2023

## Ex-Filing

**Exhibit 107.1** 

**CALCULATION OF FILING FEE TABLES** 

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**<u>Form S-8</u>**

(Form Type)

**<u>Gritstone bio, Inc.</u>**

(Exact Name of Registrant as Specified in its Charter)

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**Table 1 – Newly Registered Securities** 

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| | | | | | |
|:---|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;&nbsp;&nbsp; Security Type | Security Class Title | Fee Calculation<br>Rule | Maximum<br> aggregate<br> offering price | Fee Rate | Amount of<br> Registration Fee |
| &nbsp;&nbsp;&nbsp;Equity | Common stock, $0.0001 par value per share | Rule 457(c) and Rule 457(h)4344745<sup>(2)(3)</sup>$2.33<sup>(4)</sup> | $10123255.85 | $110.20 per $1,000,000 | $1115.59 |
| &nbsp;&nbsp;&nbsp;Equity | Common stock, $0.0001 par value per share | Rule 457(c) and Rule 457(h)1300000<sup>(5)</sup>$2.33<sup>(4)</sup> | $3029000.00 | $110.20 per $1,000,000 | $333.80 |
| &nbsp;&nbsp;&nbsp;Total Offering Amount | &nbsp;&nbsp;&nbsp;Total Offering Amount | &nbsp;&nbsp;&nbsp;Total Offering Amount | $13152255.85 |  | $1449.39 |
| &nbsp;&nbsp;&nbsp;Total Fees Offset | &nbsp;&nbsp;&nbsp;Total Fees Offset | &nbsp;&nbsp;&nbsp;Total Fees Offset |  |  | 0 |
| &nbsp;&nbsp;&nbsp;Net Fee Due | &nbsp;&nbsp;&nbsp;Net Fee Due | &nbsp;&nbsp;&nbsp;Net Fee Due |  |  | $1449.39 |

---

(1) Pursuant to Rule 416 of the Securities Act of 1933, as amended (the "Securities Act"), this
Registration Statement shall also cover any additional shares of the Registrant's Common Stock, $0.0001 par value per share ("Common Stock"), that become issuable under the Gritstone Oncology, Inc. 2018 Incentive Award Plan
("2018 Plan"), the Gritstone Oncology, Inc. 2018 Employee Stock Purchase Plan ("2018 ESPP") and the Gritstone bio, Inc. 2021 Employment Inducement Incentive Plan (the "2021 Plan") by reason of any stock dividend, stock
split, recapitalization or other similar transaction effected without receipt of consideration that increases the number of outstanding shares of Common Stock.

(2) The 2018 Plan provides for an annual increase in the number of shares reserved and available for issuance under
the 2018 Plan each January 1 until January 1, 2028, in an amount equal to four percent (4%) of the number of shares of Common Stock issued and outstanding on the immediately preceding December 31 or such lesser number of shares as
approved by the Board. The 2018 ESPP provides for an annual increase in the number of shares reserved and available for issuance under the 2018 ESPP each January 1 until January 1, 2028, in an amount equal to one percent (1%) of the number
of shares of Common Stock issued and outstanding on the immediately preceding December 31 or such lesser number of shares determined by the Board. The 4,344,745 shares of Common Stock registered hereunder consists of (i) 3,475,796 shares under
the 2018 Plan and (ii) 868,949 shares under the 2018 ESPP.

(3) The 4,344,745 shares of Common Stock registered hereunder were authorized as of January 1, 2023 pursuant to
the annual increase provisions described above.

(4) Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and (h) under
the Securities Act on the basis of $2.33 per share, which represents the average of the high and low prices of the Registrant's Common Stock as reported on the Nasdaq Global Select Market on March 9, 2023.

(5) Represents the additional shares of Common Stock available for future issuance under the Registrant's 2021
Plan resulting from an amendment adopted by the Registrant's Board of Directors as of February 2, 2023.