# EDGAR Filing Document

**Accession Number:** 0001857190
**File Stem:** 0001104659-26-035161
**Filing Date:** 2026-3
**Character Count:** 2434694
**Document Hash:** b77ef1c8c787be40486e2d5098a96d91
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-26-035161.hdr.sgml**: 20260326

**ACCESSION NUMBER**: 0001104659-26-035161

**CONFORMED SUBMISSION TYPE**: 20-F

**PUBLIC DOCUMENT COUNT**: 210

**CONFORMED PERIOD OF REPORT**: 20251231

**FILED AS OF DATE**: 20260326

**DATE AS OF CHANGE**: 20260326

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Nyxoah SA
- **CENTRAL INDEX KEY:** 0001857190
- **STANDARD INDUSTRIAL CLASSIFICATION:** SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
- **ORGANIZATION NAME:** 08 Industrial Applications and Services
- **EIN:** 000000000
- **STATE OF INCORPORATION:** C9
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 20-F
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-40552
- **FILM NUMBER:** 26797987

**BUSINESS ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** RUE EDOUARD BELIN 12
- **CITY:** MONT-SAINT-GUIBERT
- **PROVINCE COUNTRY:** C9
- **ZIP:** 1435
- **BUSINESS PHONE:** 3210222355

**MAIL ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** RUE EDOUARD BELIN 12
- **CITY:** MONT-SAINT-GUIBERT
- **PROVINCE COUNTRY:** C9
- **ZIP:** 1435

?xml version='1.0' encoding='ASCII'? NYXOAH SA_December 31, 2025

[**Table of Contents**](#TOC)

As filed with the Securities and Exchange Commission on March 26, 2026

------

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**WASHINGTON, D.C. 20549**

**FORM 20-F**

**☐** **REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934**

**OR**

&nbsp;&nbsp;&nbsp;&nbsp;**☒** **ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934** 

**For the fiscal year ended December 31, 2025**

**OR**

**☐** **TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934**

**OR**

**☐** **SHELL COMPANY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934**

**Date of event requiring this shell company report _______________________**

**For the transition period from** _______________________ to ______________________________

Commission File Number 001-40552

**NYXOAH SA**

(Exact name of Registrant as specified in its charter)

**Belgium**

(Jurisdiction of incorporation or organization)

**Rue Edouard Belin 12**

**1435 Mont-Saint-Guibert, Belgium**

**Telephone: +32 10 22 23 55**

(Address of principal executive offices)

**Olivier Taelman, Chief Executive Officer**

**Nyxoah SA**

**Rue Edouard Belin 12**

**1435 Mont-Saint-Guibert, Belgium**

**Telephone: +32 10 22 23 55**

**Email: Olivier.Taelman@nyxoah.com**

(Name, Telephone, E-mail and/or Facsimile number and Address of Company Contact Person)

**Securities registered or to be registered pursuant to Section 12(b) of the Act:**

---

| | | |
|:---|:---|:---|
| **Title of each class** | **Trading Symbol(s)** | **Name of each exchange on which registered** |
| Ordinary Share, no nominal value per share | NYXH | The Nasdaq Stock Market LLC |

---

Securities registered or to be registered pursuant to Section 12(g) of the Act: **None**

Securities for which there is a reporting obligation pursuant to Section 15(d) of the Act: **None**

Indicate the number of outstanding shares of each of the issuer's classes of capital or common stock as of the close of the period covered by the annual report: Ordinary shares, no nominal value per share: 43,026,460, as of December 31, 2025

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes ☐ No ☒

If this report is an annual or transition report, indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934. Yes ☐ No ☒

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒ No ☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒ No ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer or an emerging growth company. See definition of "large accelerated filer," "accelerated filer" and "emerging growth company" in Rule 12b-2 of the Exchange Act.

Large accelerated filer ☐ Accelerated filer ☒ Non-accelerated filer ☐ <br> Emerging growth company ☒

If an emerging growth company that prepares its financial statements in accordance with U.S. GAAP, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards† provided pursuant to Section 13(a) of the Exchange Act. ☐

† The term "new or revised financial accounting standard" refers to any update issued by the Financial Accounting Standards Board to its Accounting Standards Codification after April 5, 2012.

Indicate by check mark whether the registrant has filed a report on and attestation to its management's assessment of the effectiveness of its internal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its audit report. ☐

If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrant included in the filing reflect the correction of an error to previously issued financial statements. ☐

Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation received by any of the registrant's executive officers during the relevant recovery period pursuant to §240.10D-1(b). ☐

Indicate by check mark which basis of accounting the registrant has used to prepare the financial statements included in this filing:

U.S. GAAP ☐ International Financial Reporting Standards as issued by theInternational Accounting Standards Board ☒ Other ☐

If "Other" has been checked in response to the previous question, indicate by check mark which financial statement item the registrant has elected to follow. Item 17 ☐ Item 18 ☐

If this is an annual report, indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒

Auditor Firm Id: 01467 Auditor Name: EY Réviseurs d'Entreprises/ EY Bedrijfsrevisoren SRL/BV Auditor Location: Diegem, Belgium

------

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**TABLE OF CONTENTS**

---

| | | |
|:---|:---|:---|
|  |  | **Page** |
| [PART I](#PARTI_610404) | [PART I](#PARTI_610404) | 4 |
| [Item 1.](#Item1IdentityofDirectorsSeniorManagement) | [Identity of Directors, Senior Management and Advisers](#Item1IdentityofDirectorsSeniorManagement) | 4 |
| [Item 2.](#Item2OfferStatisticsandExpectedTimetable) | [Offer Statistics and Expected Timetable](#Item2OfferStatisticsandExpectedTimetable) | 4 |
| [Item 3.](#Item3KeyInformation_260647) | [Key Information](#Item3KeyInformation_260647) | 4 |
|  | [A. \[Reserved\]](#AReserved_450003) | 4 |
|  | [B. Capitalization and Indebtedness](#BCapitalizationandIndebtedness_613456) | 4 |
|  | [C. Reasons for the Offer and Use of Proceeds](#CReasonsfortheOfferandUseofProceeds_2607) | 4 |
|  | [D. Risk Factors](#DRiskFactors_749558) | 4 |
| [Item 4.](#Item4InformationontheCompany_716653) | [Information on the Company](#Item4InformationontheCompany_716653) | 61 |
|  | [A. History and Development of the Company](#AHistoryandDevelopmentoftheCompany_24793) | 61 |
| [Item 4A.](#Item4AUnresolvedStaffComments_693169) | [Unresolved Staff Comments](#Item4AUnresolvedStaffComments_693169) | 111 |
| [Item 5.](#Item5OperatingandFinancialReviewandProsp) | [Operating and Financial Review and Prospects](#Item5OperatingandFinancialReviewandProsp) | 111 |
| [Item 6.](#Item6DirectorsSeniorManagementandEmploye) | [Directors, Senior Management and Employees](#Item6DirectorsSeniorManagementandEmploye) | 123 |
|  | [A. Directors and Senior Management](#ADirectorsandSeniorManagement_164147) | 123 |
|  | [B. Compensation](#BCompensation_719406) | 126 |
|  | [C. Board Practices](#CBoardPractices_693094) | 134 |
|  | [D. Employees](#DEmployees_466017) | 140 |
|  | [E. Share Ownership](#EShareOwnership_700942) | 141 |
|  | [F. Disclosure of a Registrant's Action to Recover Erroneously Awarded Compensation](#FDisclosureofaRegistrantsActiontoRecover) | 141 |
| [Item 7.](#Item7MajorShareholdersandRelatedPartyTra) | [Major Shareholders and Related Party Transactions](#Item7MajorShareholdersandRelatedPartyTra) | 141 |
|  | [A. Major Shareholders](#AMajorShareholders_288347) | 141 |
|  | [B. Related Party Transactions](#BRelatedPartyTransactions_509603) | 143 |
|  | [C. Interests of Experts and Counsel](#CInterestsofExpertsandCounsel_205789) | 144 |
| [Item 8.](#Item8FinancialInformation_257247) | [Financial Information](#Item8FinancialInformation_257247) | 144 |
|  | [A. Consolidated Statements and Other Financial Information](#AConsolidatedStatementsandOtherFinancial) | 144 |
|  | [B. Significant Changes](#BSignificantChanges_651063) | 145 |
| [Item 9.](#Item9TheOfferandListing_984931) | [The Offer and Listing](#Item9TheOfferandListing_984931) | 145 |
|  | [A. Offer and Listing Details](#AOfferandListingDetails_430210) | 145 |
|  | [B. Plan of Distribution](#BPlanofDistribution_646421) | 145 |
|  | [C. Markets](#CMarkets_703415) | 145 |
|  | [D. Selling Shareholders](#DSellingShareholders_37073) | 145 |
|  | [E. Dilution](#EDilution_256528) | 145 |
|  | [F. Expenses of the Issue](#FExpensesoftheIssue_137301) | 146 |
| [Item 10.](#Item10AdditionalInformation_320087) | [Additional Information](#Item10AdditionalInformation_320087) | 146 |
|  | [A. Share Capital](#AShareCapital_967804) | 146 |
|  | [B. Articles of Association](#BArticlesofAssociation_204249) | 146 |
|  | [C. Material Contracts](#CMaterialContracts_828333) | 146 |
|  | [D. Exchange Controls](#DExchangeControls_580088) | 146 |
|  | [E. Taxation](#ETaxation_83170) | 146 |
|  | [F. Dividends and Paying Agents](#FDividendsandPayingAgents_851421) | 162 |
|  | [G. Statement by Experts](#GStatementbyExperts_376868) | 162 |
|  | [H. Documents on Display](#HDocumentsonDisplay_264151) | 162 |
|  | [I.&nbsp;&nbsp;&nbsp;&nbsp;Subsidiary Information](#ISubsidiaryInformation_172509) | 162 |
| [Item 11.](#Item11QuantitativeandQualitativeDisclosu) | [Quantitative and Qualitative Disclosures About Market Risk](#Item11QuantitativeandQualitativeDisclosu) | 162 |
| [Item 12.](#Item12DescriptionofSecuritiesOtherthanEq) | [Description of Securities Other than Equity Securities](#Item12DescriptionofSecuritiesOtherthanEq) | 163 |
|  | [A. Debt Securities](#ADebtSecurities_85286) | 163 |
|  | [B. Warrants and Rights](#BWarrantsandRights_570674) | 163 |
|  | [C. Other Securities](#COtherSecurities_868418) | 163 |
|  | [D. American Depositary Shares](#DAmericanDepositaryShares_142192) | 163 |
| [PART II](#PARTII_793328) |  | 164 |
| [Item 13.](#Item13DefaultsDividendArrearagesandDelin) | [Defaults, Dividend Arrearages and Delinquencies](#Item13DefaultsDividendArrearagesandDelin) | 164 |

---

i

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---

| | | |
|:---|:---|:---|
| [Item 14.](#Item14MaterialModificationstotheRightsof) | [Material Modifications to the Rights of Security Holders and Use of Proceeds](#Item14MaterialModificationstotheRightsof) | 164 |
| [Item 15.](#Item15ControlsandProcedures_227375) | [Controls and Procedures](#Item15ControlsandProcedures_227375) | 164 |
|  | [A. Disclosure Controls and Procedures](#ADisclosureControlsandProcedures_141689) | 164 |
|  | [B. Management's Annual Report on Internal Control over Financial Reporting](#BManagementsAnnualReportonInternalContro) | 164 |
|  | [C. Attestation Report of the Registered Public Accounting Firm](#CAttestationReportoftheRegisteredPublicA) | 166 |
|  | [D. Changes in Internal Control Over Financial Reporting](#DChangesinInternalControlOverFinancialRe) | 166 |
| [Item 16A.](#Item16AAuditCommitteeFinancialExpert_884) | [Audit Committee Financial Expert](#Item16AAuditCommitteeFinancialExpert_884) | 166 |
| [Item 16B.](#Item16BCodeofEthics_401300) | [Code of Ethics](#Item16BCodeofEthics_401300) | 166 |
| [Item 16C.](#Item16CPrincipalAccountantFeesandService) | [Principal Accountant Fees and Services](#Item16CPrincipalAccountantFeesandService) | 167 |
| [Item 16D.](#Item16DExemptionsFromtheListingStandards) | [Exemptions From the Listing Standards For Audit Committees](#Item16DExemptionsFromtheListingStandards) | 167 |
| [Item 16E.](#Item16EPurchasesofEquitySecuritiesbytheI) | [Purchases of Equity Securities by the Issuer and Affiliated Purchasers](#Item16EPurchasesofEquitySecuritiesbytheI) | 167 |
| [Item 16F.](#Item16FChangeintheRegistrantsCertifyingA) | [Change in the Registrant's Certifying Accountant](#Item16FChangeintheRegistrantsCertifyingA) | 167 |
| [Item 16G.](#Item16GCorporateGovernance_440009) | [Corporate Governance](#Item16GCorporateGovernance_440009) | 167 |
| [Item 16H.](#Item16HMineSafetyDisclosure_320423) | [Mine Safety Disclosure](#Item16HMineSafetyDisclosure_320423) | 169 |
| [Item 16I.](#Item16IDisclosureRegardingForeignJurisdi) | [Disclosure Regarding Foreign Jurisdictions That Prevent Inspections](#Item16IDisclosureRegardingForeignJurisdi) | 169 |
| [Item 16J.](#Item16JInsiderTradingPolicy_154491) | [Insider Trading Policy](#Item16JInsiderTradingPolicy_154491) | 169 |
| [Item 16K.](#Item16KCybersecurity_792274) | [Cybersecurity](#Item16KCybersecurity_792274) | 169 |
| [PART III](#PARTIII_965959) |  | 171 |
| [Item 17.](#Item17FinancialStatements_57576) | [Financial Statements](#Item17FinancialStatements_57576) | 171 |
| [Item 18.](#Item18FinancialStatements_795926) | [Financial Statements](#Item18FinancialStatements_795926) | 171 |
| [Item 19.](#Item19Exhibits_998433) | [Exhibits](#Item19Exhibits_998433) | 171 |

---

ii

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**GENERAL INFORMATION**

In this annual report on Form 20-F, or Annual Report, "Nyxoah," the "Company," "we," "us" and "our" refer to Nyxoah SA and its consolidated subsidiaries, except where the context otherwise requires.

"Nyxoah," the Nyxoah logo, Genio and other trademarks or service marks of Nyxoah appearing in this Annual Report are the property of Nyxoah or its subsidiaries. Solely for convenience, the trademarks, service marks and trade names referred to in this Annual Report are listed without the® and™ symbols, but such references should not be construed as any indicator that their respective owners will not assert, to the fullest extent under applicable law, their right thereto. All other trademarks, trade names and service marks appearing in this Annual Report are the property of their respective owners. We do not intend to use or display other companies' trademarks and trade names to imply any relationship with, or endorsement or sponsorship of us by, any other companies.

**PRESENTATION OF FINANCIAL AND OTHER DATA**

The consolidated financial statement data as at December 31, 2025 and 2024 and for the years ended December 31, 2025, 2024 and 2023 have been derived from our consolidated financial statements, which have been prepared in accordance with International Financial Reporting Standards, or IFRS, as issued by the International Accounting Standards Board, or IASB.

Our financial statements included in this Annual Report are presented in Euros and, unless otherwise specified, all monetary amounts are in Euros. All references in this Annual Report to "$", "U.S. dollars," and "dollars" are to U.S. dollars and all references to "€" and "Euro" are to Euros, unless otherwise noted.

**INFORMATION REGARDING FORWARD-LOOKING STATEMENTS**

This Annual Report contains estimates and forward-looking statements, principally in the sections titled "Risk Factors," "Operating and Financial Review and Prospects" and "Business." Some of the matters discussed concerning our operations and financial performance include forward-looking statements and estimates within the meaning of the Securities Act of 1933, as amended, and the Securities Exchange Act of 1934, as amended. The words "anticipate," "believe," "can," "could," "estimate," "expect," "intend," "is designed to," "may," "might," "plan," "potential," "predict," "objective," "should," or the negative of these and similar words are intended to identify forward-looking statements and estimates. Forward-looking statements include, but are not limited to, statements about:

● timing, progress, completion and results of clinical trials and our research and development programs;

● the timing or likelihood of regulatory filings and approvals;

● our reliance on the success of our Genio system;

● our ability to achieve and maintain adequate levels of coverage or reimbursement for procedures performed with our products and any future products we may seek to commercialize;

● the commercialization of our products;

● estimates of our expenses, future revenues, capital requirements and our needs for additional financing;

● the scope of protection we are able to establish and maintain for intellectual property rights covering our products and technology;

● our ability to operate our business without infringing the intellectual property rights and proprietary technology of third parties;

● cost associated with defending intellectual property infringement, product liability and other claims;

● regulatory development in the U.S., Europe and other jurisdictions;

● the rate and degree of market acceptance of our products;

● our expectations about market trends;

● developments relating to our competitors and our industry, including competing products;

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● our ability to accurately forecast customer demand and manage our inventory;

● our ability to effectively manage our anticipated growth;

● our ability to attract and retain qualified employees and key personnel;

● statements regarding future revenue, hiring plans, expenses, capital expenditures, capital requirements and share performance;

● our expected use of proceeds from the initial public offering on The Nasdaq Global Market;

● the future trading price of the ordinary shares and impact of securities analysts' reports on these prices;

● the impact on our business, financial condition and results of operations from regional conflicts, geopolitical events and any pandemic, epidemic or outbreak of an infectious disease in the U.S. or worldwide;

● our plans to remediate our material weaknesses; and

● other risks and uncertainties, including those listed under the caption "Risk Factors."

These forward-looking statements are subject to known and unknown risks, uncertainties, assumptions and other factors that could cause our actual results of operations, financial condition, liquidity, performance, prospects, opportunities, achievements or industry results, as well as those of the markets we serve or intend to serve, to differ materially from those expressed in, or suggested by, these forward-looking statements. Factors that could cause actual results, financial condition, liquidity, performance, prospects, opportunities, achievements or industry results to differ materially include, but are not limited to, those discussed under "Risk Factors" in this Annual Report. Additional risks that we may currently deem immaterial or that are not presently known to us could also cause the forward-looking events discussed in this Annual Report not to occur. These forward-looking statements are based on assumptions regarding our present and future business strategies and the environment in which we expect to operate in the future.

Forward-looking statements and estimates speak only at the date they were made, and we undertake no obligation to update or to review any forward-looking statement or estimate because of new information, future events or other factors. Forward-looking statements and estimates involve risks and uncertainties and are not guarantees of future performance. Our future results may differ materially from those expressed in these forward-looking statements and estimates.

Additional factors that could cause actual results, financial condition, liquidity, performance, prospects, opportunities, achievements or industry results to differ materially include, but are not limited to, those discussed under "Risk Factors" in this Annual Report. Additional risks that we may currently deem immaterial or that are not presently known to us could also cause the forward-looking events discussed in this Annual Report not to occur. The words "believe," "may," "will," "estimate," "continue," "anticipate," "intend," "expect" and similar words are intended to identify estimates and forward-looking statements. Estimates and forward-looking statements speak only at the date they were made, and we undertake no obligation to update or to review any estimate and/or forward-looking statement because of new information, future events or other factors. Estimates and forward-looking statements involve risks and uncertainties and are not guarantees of future performance. Our future results may differ materially from those expressed in these estimates and forward-looking statements. In light of the risks and uncertainties described above, the estimates and forward-looking statements discussed in this Annual Report might not occur, and our future results and our performance may differ materially from those expressed in these forward-looking statements due to, inclusive of, but not limited to, the factors mentioned above. Because of these uncertainties, you should not make any investment decision based on these estimates and forward-looking statements.

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**WEBSITE DISCLOSURE**

We maintain a public website at https://www.nyxoah.com and use our website as a routine channel of distribution of company information, including press releases, analyst presentations, and supplemental financial information, as a means of disclosing material non-public information and for complying with our disclosure obligations under Regulation FD. Our website includes an Investors section through which we make available, free of charge, our Annual Reports on Form 20-F, Reports on Form 6-K, as well as any amendments to those reports filed or furnished pursuant to the Exchange Act as soon as reasonably practicable after we electronically file such material with, or furnish it to, the SEC. Accordingly, investors should monitor our website in addition to following press releases, filings with the SEC, and public conference calls and webcasts.

None of the information provided on our website, in our press releases or public conference calls and webcasts or through social media is incorporated into, or deemed to be a part of, this Annual Report or in any other report or document we file with the SEC, and any references to such website is intended to be inactive textual references only.

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#### PART I

#### Item 1. Identity of Directors, Senior Management and Advisers
Not Applicable.

#### Item 2. Offer Statistics and Expected Timetable
Not Applicable.

#### Item 3. Key Information
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A. **[Reserved]** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;B. **Capitalization and Indebtedness** 

Not Applicable.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;C. **Reasons for the Offer and Use of Proceeds** 

Not Applicable.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;D. **Risk Factors** 

*Our business has significant risks. You should carefully consider the risks and uncertainties described below, together with all of the other information in this Annual Report, including the matters addressed in the section of the Annual Report entitled "Information Regarding Forward-Looking Statements" and in our consolidated financial statements and related notes, before deciding whether to purchase our ordinary shares. If any of the following risks are realized, our business, financial condition, operating results and prospects could be materially and adversely affected. In that event, the market price of our ordinary shares could decline, and you could lose part or all of your investment. Additional risks and uncertainties not currently known to us or that we now deem immaterial may also harm us and adversely affect our business, results of operations and financial condition.*

#### Summary of Risk Factors
*An investment in our ordinary shares is subject to a number of risks, including risks related to our business and industry, risks related to development of our product candidates, and risks related to our ordinary shares. The following summarizes some, but not all, of these risks. Please carefully consider all of the information discussed in "Item 3. Key Information—D. Risk Factors" in this Annual Report for a more thorough description of these and other risks.*

#### Risks Associated With Our Business
● We have a limited operating history, have incurred losses in each period since our inception and may not be able to achieve or maintain profitability in the future.

● Our future financial performance depends on the commercial acceptance of the Genio system in target markets.

● We will require additional capital in the future, which may not be available to us on commercially favorable terms, or at all. More specifically, there is substantial doubt about our ability to continue as a going concern for a period of at least twelve months from the date of this Annual Report and our ability to continue as a going concern will depend on our ability to obtain additional funding, as to which no assurances can be given as of the date of this Annual Report. We refer to the disclosure in this respect in note 5.1 to our consolidated financial statements and the emphasis of matter paragraph in respect of going concern in the report of the Independent Registered Public Accounting Firm found elsewhere in this Annual Report.

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● Even though we have obtained certification, a CE-Mark, in Europe for the Genio system based on first positive clinical trial results, there is no guarantee that we will be able to maintain our current certification or to obtain additional certification or marketing authorizations in other jurisdictions, including the United States, or that the results from our ongoing and planned clinical trials will be sufficient for us to obtain or maintain such certifications or authorizations.

● We may not receive, or may be delayed in receiving, the necessary marketing authorizations or certifications for our Genio system or any future product candidates, and failure to timely obtain necessary marketing authorizations or certifications for our product candidates would have a material adverse effect on our business.

● Even if we receive marketing authorizations, clearances or certifications in our target markets to commercialize the Genio system or any product candidate that we develop, the product may become subject to unfavorable pricing regulations, third-party payor reimbursement practices or healthcare reform initiatives that could harm our business.

● A pandemic, epidemic, or outbreak of an infectious disease, such as the COVID-19 pandemic, could materially and adversely affect our business and our financial results and cause a disruption to our research, development and commercialization efforts.

● A loss or degradation in performance of the suppliers on which we depend for services and components used in the production and assembly of the Genio system could have a material effect on our business, financial condition and results of operations.

● We may not be able to manufacture or outsource manufacturing of the Genio system in sufficient quantities, in a timely manner or at a cost that is economically attractive.

● Our products and operations are subject to extensive government regulation and oversight both in the United States and abroad, and our failure to comply with applicable requirements could harm our business.

● The Genio system is still unapproved in certain significant markets, such as the United States market, and seeking and obtaining regulatory authorization or certification for active implantable medical devices can be a long, expensive and uncertain process.

● Security breaches and other disruptions could compromise our information and expose us to liability, which would cause our business and reputation to suffer.

● We rely significantly on information technology and any failure, inadequacy, interruption or security lapse of that technology or loss of data, including any cyber security incidents, could compromise sensitive information related to our business, prevent us from accessing critical information or expose us to liability which could harm our ability to operate our business effectively and adversely affect our business and reputation.

● Our inability to fully protect and exploit our intellectual property and trade secrets may adversely affect our financial performance and prospects.

● The dual listing of our ordinary shares may adversely affect the liquidity and value of the ordinary shares.

● We or the third parties upon which we depend may be adversely affected by general political, unstable market and economic conditions and other events beyond our control and our business continuity and disaster recovery plans may not adequately protect us from a serious disaster.

● Climate change or legal, regulatory or market measures to address climate change may negatively affect our business, results of operations, cash flows and prospects.

● In connection with our preparation and the audit of our consolidated financial statements as of and for the year ended December 31, 2025, we identified material weaknesses in our internal control over financial reporting. Additionally, we may identify additional material weaknesses in the future that may cause us to fail to meet our reporting obligations or result in material misstatements in our financial statements. If we fail to remediate our material weaknesses, we may not be able to report our financial results accurately or prevent fraud.

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#### Risks Related to Our Financial Position
***We have a limited operating history, have incurred losses in each period since our inception and may not be able to achieve or maintain profitability in the future.***

We were incorporated in 2009, obtained certification (CE-Mark) for our Genio system in March 2019, had our first commercial sales in Germany in July 2020, received FDA approval for our Genio system in August 2025 and had our first commercials sales in the United States in September 2025. In 2025 we generated €10.0 million of sales from the Genio system compared to €4.5 million in 2024. We have incurred operating losses and negative operating cash flows in each period since we were incorporated in 2009, including operating losses of €83.5 million and €58.8 million and negative operating cash flows of €69.0 million and €49.2 million for each of the years ended December 31, 2025 and December 31, 2024, respectively. As of December 31, 2025, we had an accumulated deficit of €306.0 million. These losses have resulted primarily from costs incurred in the development of our Genio system, as well as from general and administrative costs associated with our operations and manufacturing.

We will continue to invest in the continued development of our technology and the Genio product line, seek to expand manufacturing and sales and marketing capabilities, seek further regulatory clearances, certifications, approvals and marketing authorizations for the Genio system, and incur the additional costs associated with being a public company in the United States, most notably Sarbanes-Oxley compliance. In June 2020, we obtained approval from the FDA under an investigational device exemption, or IDE, to begin our pivotal trial, the dual-sided hypoglossal nerve stimulation for the treatment of obstructive sleep apnea, or DREAM, trial. The aim of the DREAM trial was to support market authorization of the Genio system in the United States, as well as to support obtaining coverage and reimbursement more generally. In August 2025, we received FDA approval for our Genio system. We expect our total operating expenses to increase as we expand our sales and marketing capabilities in the United States.

As a result, we expect to continue to incur operating losses for the foreseeable future, and we may never achieve profitability, which could impair our ability to sustain operations or obtain any required additional funding. Furthermore, even if we do achieve profitability, we may not be able to sustain or increase profitability on an ongoing basis. If we do not achieve or sustain profitability in the future, we may suffer net losses or negative operating cash flows in subsequent periods.

#### Our future financial performance depends on the commercial acceptance of the Genio system in target markets.
The Genio system is currently our only commercial product, which we market among others in certain European countries as well as in the United States, and our success depends entirely upon its market acceptance and adoption by physicians, payors and patients. The Genio system may not gain commercial acceptance in target markets. If we fail to gain and maintain commercial market acceptance of the Genio system in our target markets, for instance, because of insufficient price and reimbursement levels from government and third-party payors, competition, or the inability to demonstrate the benefits and cost-effectiveness of the Genio system compared to other products available on the market, the amount of revenue generated from sales of the Genio system in the future could continue to be limited, and could even decrease over time.

These and other factors present obstacles to commercial acceptance of the Genio system in target markets and could lead to our failure, or a substantial delay, in gaining significant market acceptance of the Genio system in target markets, which could affect our ability to generate revenue. Any failure of the Genio system to achieve meaningful market acceptance will harm our business and future prospects.

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***We will require additional capital in the future, which may not be available to us on commercially favorable terms, or at all. More specifically, there is substantial doubt about our ability to continue as a going concern for a period of at least twelve months from the date of this Annual Report and our ability to continue as a going concern will depend on our ability to obtain additional funding, as to which no assurances can be given as of the date of this Annual Report.***

We expect to incur significant expenses and operating losses over the next few years, and we may need to raise additional capital in the future. We have so far been financed primarily by funds invested by our shareholders, including in connection with our initial public offering on Euronext Brussels in September 2020, the listing of our ordinary shares on the Nasdaq Global Market in July 2021, the issuance of ordinary shares in a public offering in May 2024 and the sale of ordinary shares via an at the market offering. In July 2024, we entered into a €37.5 million loan facility agreement with the European Investment Bank, and, in November 2025, we secured €22 million in financing through the issuance shares in a private placement in Europe and a registered direct offering in the United States, combined with a convertible bond financing of up to €45.0 million. Based on our current operating plan and our existing cash and cash equivalents of €30.0 million and financial assets of €18.0 million as of December 31, 2025, and taking into account the full convertible bond financing, as well as the second tranche under the Company's existing loan facility agreement with the European Investment Bank (for which the possibility to draw depends on a revenue milestone that the Company expects to meet in the first half of 2026), the Company's cash runway is expected to be extended into the first quarter of 2027, which means that we may not be able to fund our operations for at least 12 months as from the date of this Annual Report. However, we have based these estimates on assumptions that may prove to be incorrect, and we could spend our financial resources much faster than currently expected. Pursuant to the requirements of IAS 1.25-26, Presentation of Financial Statements - Going Concern, and as a result of our financial condition and other factors described herein, there is substantial doubt about our ability to continue as a going concern for a period of at least twelve months from the date of this Annual Report. See Note 5.1 to our consolidated financial statements found elsewhere in this Annual Report. Our ability to continue as a going concern will depend on our ability to obtain additional funding, as to which no assurances can be given. Our future success depends on our ability to raise capital and/or execute our current operating plan. Any future funding requirements will depend on many factors, including without limitation:

● acceptance of our Genio system by patients, physicians, government payors, private payors, and the market generally in our target markets;

● the scope, rate of progress, cost and outcomes of current or future clinical trials;

● the cost and timing of obtaining additional regulatory clearances, approvals, classifications, certifications or other marketing authorizations for the Genio system;

● the cost and timing of establishing additional sales and marketing capabilities;

● the cost of research and development activities;

● the cost of filing and prosecuting patent applications and other intellectual property rights and defending and enforcing our patents or other intellectual property rights in various jurisdictions;

● the cost of defending, in litigation or otherwise, any claims that we infringe third-party patents or other intellectual property rights;

● the cost associated with any complications or side effects related to the use of the Genio system;

● costs associated with any product recall that may occur;

● the effect of competing technological and market developments;

● the extent to which we acquire or invest in products, technologies and businesses, although we currently have no commitments or agreements relating to any of these types of transactions; and

● the costs of operating as a public company in Belgium and the United States.

Any additional equity or debt financing that we raise may contain terms that are not favorable to us or our shareholders. If we raise additional funds by selling additional ordinary shares or other securities convertible into or exercisable or exchangeable for ordinary shares, the issuance of such securities will result in dilution to our shareholders.

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In addition, any future debt financing into which we enter may impose upon us covenants that restrict our operations, including limitations on our ability to incur liens or additional debt, pay dividends, repurchase our ordinary shares, make certain investments and engage in certain merger, consolidation or asset sale transactions. If we raise additional funds through collaboration and licensing arrangements with third parties, it may be necessary to relinquish some rights to our technologies or products, or grant licenses on terms that are not favorable to us.

Furthermore, we cannot be certain that additional funding will be available on acceptable terms, if at all. We have no committed source of additional capital other than our at-the-market facility. If we do not have, or are not able to obtain, sufficient funds, we may have to delay development or commercialization of our products or license to third-parties the rights to commercialize products or technologies that we would otherwise seek to commercialize ourselves. We also may have to reduce marketing, customer support or other resources devoted to our products or cease operations, or even terminate our operations, which may involve seeking bankruptcy protection.

***Covenants under the Bond Instrument, as supplemented, relating to our €22.5 million Amortising Senior Unsecured Convertible Bonds due 2028 and any future debt arrangements may result in the acceleration of outstanding indebtedness and limit the manner in which we operate.***

The Bond Instrument, dated as of December 18, 2025, as supplemented by the First Supplemental Bond Instrument, dated as of February 2, 2026, relating to our €22.5 million Amortising Senior Unsecured Convertible Bonds due 2028 contains customary terms and covenants, as well as customary events of default, after which the bonds may be due and payable immediately, including defaults related to payment compliance, failure to deliver ordinary shares, material breaches of representations and warranties, covenant compliance, and bankruptcy, reorganization or liquidation events,.

In addition, the Bond Instrument contains, and any future indebtedness we incur may contain, various negative covenants that restrict or may restrict, among other things, our ability to:

● create or permit to subsist any mortgage, charge, pledge, lien or other security interest without first securing the obligations under the Bond Instrument;

● create, incur, assume or otherwise become liable in respect of additional indebtedness;

● enter into a transaction or series of transactions to sell, lease, transfer or otherwise dispose of assets or enter into any amalgamation, demerger, merger, consolidation or corporate reconstruction, subject to certain exceptions;

● enter into any transactions with affiliates, unless on terms that could be obtained in an arm's-length transaction;

● cause or permit to exist any consensual encumbrance or restriction on our ability to perform and comply with obligations pursuant to the Bond Instrument; and

● amend, modify, or vary any term of the existing EIB Facility or enter into any new agreements, instruments or other arrangements with the European Investment Bank that could reasonably be expected to impair, prohibit or limit our ability to perform our obligations under the Bond Instrument;

As a result, we are limited in the manner in which we conduct our business and we may be unable to engage in favorable business activities, repurchase our ordinary shares or finance future operations or capital needs.

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Our ability to make scheduled payments of the principal of, to pay interest on or to refinance our indebtedness depends on our future performance, which is subject to economic, financial, competitive and other factors beyond our control. Our business may not generate cash flow from operations in the future sufficient to service our debt and make necessary capital expenditures. If we are unable to generate such cash flow, we may be required to adopt one or more alternatives, such as selling assets, restructuring debt or obtaining additional equity capital on terms that may be onerous or highly dilutive. If we are unable to make our installment payments in cash, we may be forced to issue a significant number of ordinary shares which could dilute existing shareholders. Our ability to refinance our indebtedness will depend on the capital markets and our financial condition at such time. We may not be able to engage in any of these activities or engage in these activities on desirable terms, which could result in a default on our debt obligations.

#### Any loss or decrease of subsidies, reimbursable cash advances and tax reductions may affect our financial resources.
Since September 2011, we have received financial support from the Walloon Region in the form of recoverable cash advances and subsidies. In March 2018, in accordance with Section 27A of the Australian Industry Research and Development Act 1986, the Australian Government gave notice to Nyxoah Pty Ltd, our Australian subsidiary, of registration for the research and development, or R&D, tax incentive from the 2017/2018 income year. This incentive represents 48.5% of the yearly eligible R&D expenditure. In October 2023, we received confirmation from the Walloon Region that we can apply tax credits in Belgium on eligible R&D investments. All these subsidies and reimbursable cash advances increased our financial resources to support R&D and clinical development projects. However, we cannot predict whether we or our subsidiaries will continue to benefit from such incentives and/or advantages and/or to what extent. The repayment obligations with respect to the financial support from the Walloon Region will also have the effect of reducing our profitability until fully repaid.

***Adverse developments affecting the financial services industry, such as actual events or concerns involving liquidity, defaults or nonperformance by financial institutions or transactional counterparties, could adversely affect our current and projected business operations and its financial condition and results of operations.***

Actual events involving limited liquidity, defaults, non-performance or other adverse developments that affect financial institutions, transactional counterparties or other companies in the financial services industry or the financial services industry generally, or concerns or rumors about any events of these kinds or other similar risks, have in the past and may in the future lead to market-wide liquidity problems. For example, on March 10, 2023, Silicon Valley Bank, or SVB, was closed by the California Department of Financial Protection and Innovation, which appointed the Federal Deposit Insurance Corporation, or the FDIC, as receiver. Similarly, on March 12, 2023, Signature Bank and Silvergate Capital Corp. were each swept into receivership. If any of our counterparties to any credit agreements, letters of credit or certain other financial instruments that we may enter into in the future were to be placed into receivership, we may be unable to access such funds. In addition, if any parties with whom we conduct business are unable to access funds pursuant to such instruments or lending arrangements with such a financial institution, such parties' ability to pay their obligations to us or to enter into new commercial arrangements requiring additional payments to us could be adversely affected. Similar impacts have occurred in the past, such as during the 2008-2010 financial crisis.

Inflation and rapid increases in interest rates have led to a decline in the trading value of previously issued government securities with interest rates below current market interest rates. There is no guarantee that the U.S. Department of Treasury, FDIC and Federal Reserve Board will provide access to uninsured funds in the future in the event of the closure of other banks or financial institutions, or that they would do so in a timely fashion.

Although we assess our banking relationships as we believe necessary or appropriate, our access to funding sources and other credit arrangements in amounts adequate to finance or capitalize our current and projected future business operations could be significantly impaired by factors that affect us, the financial institutions with which we have arrangements directly, or the financial services industry or economy in general. These factors could include, among others, events such as liquidity constraints or failures, the ability to perform obligations under various types of financial, credit or liquidity agreements or arrangements, disruptions or instability in the financial services industry or financial markets, or concerns or negative expectations about the prospects for companies in the financial services industry. These factors could involve financial institutions or financial services industry companies with which we have financial or business relationships, but could also include factors involving financial markets or the financial services industry generally.

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In addition, investor concerns regarding the U.S. or international financial systems could result in less favorable commercial financing terms, including higher interest rates or costs and tighter financial and operating covenants, or systemic limitations on access to credit and liquidity sources, thereby making it more difficult for us to acquire financing on acceptable terms or at all. Any decline in available funding or access to our cash and liquidity resources could, among other risks, adversely impact our ability to meet our operating expenses, financial obligations or fulfill our other obligations, result in breaches of our financial and/or contractual obligations or result in violations of federal or state wage and hour laws. Any of these impacts, or any other impacts resulting from the factors described above or other related or similar factors not described above, could have material adverse impacts on our liquidity and our current and/or projected business operations and financial condition and results of operations.

In addition, any further deterioration in the macroeconomic economy or financial services industry could lead to losses or defaults by parties with whom we conduct business, which in turn, could have a material adverse effect on our current and/or projected business operations and results of operations and financial condition. For example, a party with whom we conduct business may fail to make payments when due, default under their agreements with us, become insolvent or declare bankruptcy. Any bankruptcy or insolvency, or the failure to make payments when due, of any counterparty of ours, or the loss of any significant relationships, could have material adverse impacts on our liquidity and our current and/or projected business operations and financial condition and results of operations.

#### Risks Related to Development of Our Products and Product Candidates
***Even though we have obtained CE-Mark approval in Europe and FDA approval in the United States for the Genio system, there is no assurance that we will be able to maintain these marketing authorizations or to obtain additional certifications or marketing authorizations in other jurisdictions, or that the results from our ongoing and planned clinical trials will be sufficient for us to obtain or maintain such certifications or authorizations.***

Even though we have obtained CE-Mark approval in Europe for the Genio system based on positive results from our BiLAteral hypoglossal nerve stimulation for treatment of Obstructive Sleep Apnea, or BLAST, clinical trial, and FDA approval in the United States based on our Dual-sided hypoglossal neRvE stimulAtion for the treatMent of Obstructive Sleep Apnea, or DREAM, clinical trial, there is no assurance that ongoing or future clinical trials we may conduct to support further marketing authorizations, certifications or clearances (or to maintain existing ones) will be successful or that the Genio system will perform as intended. We may be required to develop more clinical evidence than we currently anticipate before we are able to demonstrate to the satisfaction of regulatory authorities that the Genio system is safe and effective for its intended use, if ever.

To obtain and maintain regulatory approvals and authorizations, manufacturers must comply with the applicable regulatory requirements in the jurisdictions where they operate. In Europe, that includes demonstrating conformity with the applicable requirements of the EU Medical Devices Directive (Council Directive 93/42/EEC), the Active Implantable Medical Devices Directive (Council Directive 90/385/EEC) or Medical Device Regulation (EU) 2017/745 of the European Parliament, including requirements relating to safety and performance. In the United States, manufacturers seeking approval through the PMA process must provide valid scientific evidence, which typically includes extensive preclinical testing and, in most cases, one or more clinical studies, to demonstrate that a device is safe and effective for its intended use.

However, if the Genio system causes or contributes to patient injuries or other adverse events, or if other significant issues arise, we could face increased regulatory scrutiny and legal challenges, be required to conduct additional clinical trials, or risk losing existing certifications or authorization, which could adversely affect our business and damage our reputation as a company.

***If we fail to obtain regulatory authorizations in other countries for existing or future product candidates, we will not be able to commercialize these product candidates and technologies in those countries.***

In order for us to market the Genio system in countries outside of the United States, we must comply with extensive safety and quality regulations in those countries relating to product quality, safety and efficacy. These regulations, including requirements for obtaining marketing authorization and the time required for regulatory review, vary from country to country. Failure to obtain marketing authorization in any foreign country in which we plan to market the Genio system could adversely affect our ability to generate revenue and harm our business.

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Marketing authorization requirements and processes vary between countries and can involve additional product testing and administrative review periods. The time required to obtain marketing authorization in other countries might differ from that required to obtain CE-mark or FDA approvals. The pre-market review and authorization process in other countries may involve risks similar to those associated with the EU CE-marking process and the FDA's device marketing authorization processes, as well as other potential risks relating to delays, refusals, or uncertainties in the application preparation, submission, and review procedures specific to those countries.

Regulatory authorization of a medical device in one country does not ensure regulatory authorization in another, but a failure or delay in obtaining marketing authorization in one country may negatively affect the regulatory review or authorization processes in other countries. Any failures to obtain, or delay in obtaining, regulatory authorization outside the United States could have adverse effects similar to those associated with delays or failures in obtaining FDA authorization in the United States.

***We may not receive, or may experience delays in receiving, the necessary marketing authorizations or certifications for any future product candidates, and failure to timely obtain necessary marketing authorizations or certifications for our product candidates could have a material adverse effect on our business.***

In the United States, before we can market a new medical device, or a new use of, or other significant modification to, an existing, marketed medical device, we must first receive either clearance under Section 510(k) of the Federal Food, Drug, and Cosmetic Act, or the FDCA, approval of a premarket approval, or PMA, application or grant of a De Novo classification request from the FDA, unless an exemption applies.

The PMA approval, 510(k) clearance and De Novo classification processes can be expensive, lengthy and uncertain. The FDA's 510(k) clearance process can take anywhere from three to 12 months or longer to complete. The process of obtaining a PMA or De Novo classification is much more costly and uncertain than the 510(k) clearance process and generally takes from one to three years, or even longer, from the time the application is submitted to the FDA. In addition, PMAs and De Novo classification requests generally require the applicant to have conducted one or more clinical trials. In connection with the review of a PMA application, the FDA generally conducts a pre-approval inspection (PAI) of one or more manufacturing facilities to evaluate compliance with applicable quality system regulations, and any deficiencies identified during such inspection may delay or prevent approval.

Despite the time, effort and cost expended in seeking a marketing authorization, there is no assurance that the FDA will grant it. Any delay or failure to obtain necessary regulatory marketing authorizations could harm our business. Furthermore, even if we are granted such marketing authorizations, they may include significant limitations on the indicated uses for the device, which may limit the potential commercial market for the device.

In the EU, new products and certain product modifications require conformity assessment under the Medical Device Regulation (EU) 2017/745 including review by a Notified Body and evaluation of clinical data supporting the safety and performance of the products during normal conditions of use. Specifically, a manufacturer must demonstrate that the device achieves its intended performance, that its risks, are acceptable when weighed against the benefits, and that any claims made about the performance and safety of the device are supported by suitable evidence. Obtaining CE mark approval for future products or modifications may require additional clinical evidence, product testing or documentation beyond what we currently anticipate. If we are unable to meet these requirements, or if a Notified Body disagrees with our assessment of the data, we may not obtain CE marking on a timely basis, or at all, which would prevent us from marketing the affected products in the EU and the EEA.

Following the end of the "Brexit" transition period, from January 1, 2021 onwards, the UK Medicines and Healthcare products Regulatory Agency, or MHRA became responsible for the medical device market in the UK, which consists of Great Britan (England, Scotland and Wales) and Northern Ireland. Medical devices placed on the UK market must be registered with the MHRA, and manufacturers based outside the UK must appoint a UK Responsible Person to register devices, which increases our administrative burden and compliance costs.

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While Great Britain will continue to recognize CE markings for devices compliant with the MDR until June 30, 2030, devices placed on the market after such date will require a UK Conformity Assessed (UKCA) mark. In contrast, devices placed on the market in Northern Ireland continue to be subject largely to EU medical device rules. Because UKCA marking alone is not recognized in the EU, we may be required to obtain separate regulatory authorizations in the UK and EU for the same product. As a result, we may be required to comply with multiple regulatory frameworks in order to market new or modified products within the UK and EU, which could increase the time and cost required to launch products in such markets.

Swtizerland's medical device regulatory framework is largely aligned with the MDR, and CE marked devices are generally recognized subject to Swiss-specific requirements. In order to place products on th emarket in Switzerland, manufacturers who are not based in Switzerland must appoint a Swiss Authorized Representative (CH-Rep). Failure to appoint a CH-Rep could prevent us from marketing new products in Switzerland. In addition, the requirement to appoint and maintain a CH-Rep may increase our compliance costs and administrative burden.

Other jurisdictions in which we may seek to market our products impose their own regulatory requirements, which may require additional testing, documentation or approvals and could result in further delays or increased costs.

Regulatory authorities or conformity assessment bodies (such as Notified Bodies) can delay, limit or deny marketing authorization or certification of a device for many reasons, including:

● our inability to demonstrate to the satisfaction of applicable regulatory authorities or conformity assessment bodies that our products meet safety and performance requirements for their intended uses;

● disagreement by regulatory authorities or conformity assessment bodies with the design or implementation of our clinical trials or the interpretation of data from non- clinical studies or clinical trials;

● serious or unexpected adverse device effects experienced by participants in our clinical trials;

● insufficient data from our non-clinical studies or clinical trials to support marketing authorization or certification, where required;

● our inability to demonstrate that the clinical and other benefits of the device outweigh its risks;

● manufacturing process or facilities that do not meet applicable regulatory requirements; and

● changes in standards, policies or regulations that render our clinical data or regulatory submissions insufficient for marketing authorization or certification.

***Modifications to the Genio system, or to any other products for which we obtain marketing authorization, may require us to obtain supplemental or new regulatory authorizations in the jurisdictions where such products are marketed, or may require us to recall or cease marketing the affected products until such additional authorizations are obtained.***

In the United States, certain modifications to our products for which we have obtained marketing authorization may require the submission of PMA supplements or new PMA applications. If a modification is implemented to address a safety concern, we may also need to initiate a recall or cease distribution of the affected device. The FDA can review a manufacturer's determination that a modification does not require a PMA supplement or new PMA application and may disagree, or may on its own initiative determine that submission of a PMA supplement or new PMA application is required.

We may make additional modifications to our products in the future that we believe do not require a supplemental or new marketing authorization. If we begin manufacture and distribution of the modified devices and the FDA later disagrees with our determination and requires the submission of a PMA supplement or new PMA application, we may also be required to recall the distributed modified devices and to stop distribution until we receive the required marketing authorization, which could have an adverse effect on our business. If the FDA does not approve the modified devices, we may need to redesign them, which could also harm our business.

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When a device is commercialized in the United States without the required marketing authorization, the FDA has the authority to take enforcement actions such as issuing Warning Letters or bring additional enforcement actions, including injunction, seizure and recommending criminal prosecution to the U.S. Department of Justice. The FDA is more likely to initiate more severe enforcement actions when there is a serious risk to public health or safety or where corrective and preventive actions are inadequate to address the FDA's concerns.

For those products sold in the EEA/EU, significant changes to the devices or substantial changes to our quality management system may require notification to, or approval by, an EU Notified Body. Where we determine that such modifications require new or supplemental marketing authorization, we may not be able to obtain such authorization in a timely manner, or at all. Delays in obtaining required authorizations could adversely affect our ability to introduce new or enhanced products in a timely manner, which in turn could harm our future growth.

***Our growth will depend, in part, on our ability to expand the indications for the Genio system, as well as to continue to development enhancements to the system and also develop and commercialize additional products.***

Expanding indications for our Genio system and developing new products is expensive and time-consuming and could divert management's attention away from our core business. We plan to continue to invest in pursuing additional indications for our Genio system and in improving the Genio system to develop next generation versions designed to improve patient comfort, efficacy and convenience. For example, in July 2022, we received FDA approval for an IDE to enable us to initiate a clinical trial, called ACCCESS, to evaluate the use of the Genio system for the treatment of adult patients with moderate-to-severe OSA with complete concentric collapse (CCC).

The success of any such product development efforts will depend on several factors, including our ability to do the following:

● properly identify and anticipate physician and patient needs;

● develop and introduce new products and product enhancements in a timely manner;

● avoid infringing upon the intellectual property rights of third parties;

● obtain necessary licenses from or reach commercial agreements with third parties owning proprietary technologies or solutions;

● demonstrate, if required, the safety and efficacy of new products with data from non-clinical studies and clinical trials;

● obtain the necessary regulatory authorizations and/or certifications for expanded indications, new products or product modifications;

● be fully compliant with requirements related to marketing of new devices or modified products;

● provide adequate training to potential users of our products;

● receive adequate coverage and reimbursement for procedures performed with our products; and

● develop an effective and dedicated sales and marketing team.

If we are not successful in expanding indications and developing and commercializing new products and product enhancements, our ability to increase our revenue in the future may be impaired.

***Clinical trials involve a lengthy and expensive process with an uncertain outcome. We may incur additional costs or experience delays in completing, or ultimately be unable to complete, the development and commercialization of our product candidates.***

We obtained CE-Mark certification in Europe for the Genio system in March 2019, commenced sales of the Genio system in Germany in July 2020, and are pursuing marketing activities in advance of commencing selling efforts in several other European countries. In the United States, we obtained FDA approval for the Genio system through the PMA process in August 2025 and have commenced commercialization in the U.S. market.

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Before obtaining marketing clearance, approval or certification from regulatory authorities or Notified Bodies respectively for the sale of our Genio system, or any additional products we may develop, we must conduct clinical trials to demonstrate the safety and efficacy of the device in humans. Clinical testing is expensive, difficult to design and implement, can take many years to complete and is uncertain as to outcome. A failure of one or more clinical trials can occur at any stage of testing.

The outcome of prior clinical trials may not be predictive of the success of later clinical trials. For example, the positive outcome of our BLAST clinical trial, based on which we obtained certification for the Genio system in the EU, and of our DREAM trial based on which we obtained FDA approval for the Genio system in the United States, does not ensure that our ACCCESS or other future clinical trials such as BREATHE will be successful. Furthermore, interim results of a clinical trial do not necessarily predict final results. Product candidates in pivotal clinical trials may fail to show the desired safety and efficacy despite having progressed through non-clinical studies and earlier clinical trials. Many companies in the medical device industry have suffered significant setbacks in pivotal clinical trials after achieving positive results in earlier development, and we cannot be certain that we will not face such setbacks in the future.

The design of a clinical trial can determine whether its results will support marketing authorization or certification of a product, and flaws in the design of a clinical trial may not become apparent until the clinical trial is well advanced or completed. We have limited experience in designing clinical trials, and there is no certainty that the design of our ongoing or future clinical trials will ultimately support marketing authorization or certification. Even if we believe that the results of clinical trials for our product candidates warrant marketing authorization or certification, the FDA or comparable non-U.S. regulatory authorities and Notified Bodies may disagree and may not grant marketing authorization or certification of our product candidates.

In some instances, there can be significant variability in safety or efficacy results between different clinical trials of the same product candidate due to numerous factors, including changes in trial procedures set forth in protocols, differences in the size and type of the patient populations, changes in and adherence to the clinical trial protocols and the rate of dropout among clinical trial participants. Any pivotal or other clinical trials that we may conduct may not demonstrate the efficacy and safety to the degree necessary, if at all, to obtain regulatory approval to market our product candidates.

The initiation and completion of clinical trials may be prevented, delayed, or halted for numerous reasons. We may experience delays in our clinical trials for a number of reasons, which could adversely affect the costs, timing or successful completion of our clinical trials, including related to the following:

● we may be required to submit additional IDEs to the FDA, which must become effective prior to commencing certain human clinical trials of medical devices, and the FDA may reject our IDE application and notify us that we may not begin clinical trials, or place restrictions on the conduct of such trials;

● regulators and other comparable foreign regulatory authorities may disagree as to the design or implementation of our clinical trials;

● regulators and/or institutional review boards, or IRBs, or other bodies may not authorize us or our investigators to commence a clinical trial, or to conduct or continue a clinical trial at a prospective or specific trial site;

● we may not reach agreement on acceptable terms with prospective contract research organizations, or CROs, and clinical trial sites, the terms of which can be subject to extensive negotiation and may vary significantly among different CROs and trial sites;

● clinical trials may produce negative or inconclusive results, and we may decide, or regulators may require us, to conduct additional clinical trials or abandon product development programs;

● our third-party contractors may fail to comply with regulatory requirements or meet their contractual obligations to us in a timely manner, or at all;

● we might have to suspend or terminate clinical trials for various reasons, including occurrence of adverse events or other findings that the subjects in our clinical trials are being exposed to unacceptable health risks;

● we may have to amend clinical trial protocols or conduct additional studies to reflect changes in regulatory requirements or guidance, which we may be required to submit to an IRB or other bodies and/or regulatory authorities for re-examination;

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● regulators, IRBs, or other parties or bodies may require or recommend that we or our investigators suspend or terminate clinical research for various reasons, including safety signals or noncompliance with regulatory requirements;

● the cost of clinical trials may be greater than we anticipate;

● clinical sites may not adhere to the clinical protocol or may drop out of a clinical trial;

● we may be unable to recruit a sufficient number of clinical trial sites;

● regulators or other bodies may fail to approve or subsequently find fault with our manufacturing processes or facilities of third-party manufacturers with which we enter into agreement for clinical and commercial supplies, the supply of devices or other materials necessary to conduct clinical trials may be insufficient, inadequate or not available at an acceptable cost, or we may experience interruptions in supply;

● our ability to market Genio in the United States may be limited or eliminated should BREATHE study results be unacceptable;

● approval policies or regulations of FDA or applicable foreign regulatory agencies may change in a manner rendering our clinical data insufficient for approval; and

● our current or future products may have undesirable side effects or other unexpected characteristics.

Any of these occurrences may significantly harm our business, financial condition and prospects. In addition, many of the factors that cause, or lead to, a delay in the commencement or completion of clinical trials may also ultimately lead to the denial of regulatory approval of any product candidate.

The U.S. Congress also recently amended the FDCA to require sponsors of a pivotal study of a new device to support marketing authorization, to design and submit a diversity action plan for such clinical trial. The action plan must describe appropriate diversity goals for enrollment, as well as a rationale for the goals and a description of how the sponsor will meet them. Our ACCCESS trial is considered a pivotal trial but was initiated before the diversity action plan requirement became effective. For any future pivotal trials we plan to conduct for the Genio system or any other product candidate, we must submit a diversity action plan to the FDA by the time we submit a pivotal study protocol to the agency for review, unless we are able to obtain a waiver for some or all of the requirements for a diversity action plan. Initiation of such trials may be delayed if the FDA objects to our proposed diversity action plans for any future pivotal trial for our product candidates, and we may experience difficulties recruiting an adequately diverse population of patients in attempting to fulfill the requirements of any approved diversity action plan.

In addition, clinical trials must be conducted in accordance with the laws and regulations of the FDA and other applicable regulatory authorities' legal requirements, regulations or guidelines, and are subject to oversight by these governmental agencies and IRBs or other bodies at the medical institutions where the clinical trials are conducted. In addition, clinical trials must be conducted with supplies of our devices produced under current good manufacturing practice, or cGMP, requirements and other regulations. Furthermore, we rely on clinical trial sites, and we may in the future rely on CROs to ensure the proper and timely conduct of our clinical trials and while we have agreements governing their committed activities, we have limited influence over their actual performance. We depend on our collaborators and on medical institutions and we may in the future depend on CROs to conduct our clinical trials in compliance with good clinical practice, or GCP, requirements. To the extent our collaborators or the CROs fail to enroll participants for our clinical trials, fail to conduct the trial to GCP standards or are delayed for a significant time in the execution of trials, including achieving full enrollment, we may be affected by increased costs, program delays, regulatory enforcement actions or all three. In addition, conducting clinical trials in various countries may subject us to further delays and expenses as a result of increased shipment costs, additional regulatory requirements and the engagement of non-U.S. service providers, as well as expose us to risks associated with clinical investigators who are unknown to the FDA, and different standards of diagnosis, screening and medical care.

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***Interim, "top-line" and preliminary data from our clinical trials that we announce or publish from time to time may change as more trial subject data become available and are subject to audit and verification procedures that could result in material changes in the final data.***

From time to time, we may publicly disclose interim, top-line or preliminary data from our clinical trials, which are based on a preliminary analysis of then-available data, and the results and related findings and conclusions are subject to change following a more comprehensive review of the data related to the particular trial. We also make assumptions, estimations, calculations and conclusions as part of our analyses of data, and we may not have received or had the opportunity to fully and carefully evaluate all data. Importantly, interim data from clinical trials are subject to the risk that one or more of the clinical outcomes may materially change as patient enrollment continues and more patient data become available. As a result, the interim, top-line or preliminary results that we report may differ from future results of the same trial, or different conclusions or considerations may qualify such results, once additional data have been received and fully evaluated. Interim, top-line or preliminary data also remain subject to audit and verification procedures that may result in the final data being materially different from the interim, top-line or preliminary data we previously published.

Further, others, including regulatory agencies, may not accept or agree with our assumptions, estimates, calculations, conclusions or analyses or may interpret or weigh the importance of data differently, which could impact the value of the particular program, the approvability or commercialization of the particular product candidate or product and our company in general. In addition, the information we choose to publicly disclose regarding a particular non-clinical study or clinical trial is based on what is typically extensive information, and others may not agree with what we determine is material or otherwise appropriate information to include in our disclosure. If the interim top-line or preliminary data that we report differ from actual results, or if others, including regulatory authorities, disagree with the conclusions reached, our ability to obtain approval for, and commercialize, our products and product candidates may be harmed, which could harm our business, operating results, prospects or financial condition. Further, disclosure of interim data by us or by our competitors could result in volatility in the price of our common stock. For all of the foregoing reasons, interim, top-line and preliminary data should be viewed with caution until the final data are available.

***Attracting patients to perform clinical trials and meeting clinical trial objectives can be more costly and time-consuming than expected and could be adversely affected by another health crisis.***

In order to conduct our clinical trials, we must recruit, screen and enroll eligible patients. Patients may be identified from the investigator's own clinical practice or hospital or may be referred by another physician. Potential clinical trial participants must provide informed consent before undergoing certain clinical tests that are used to determine patient eligibility based on inclusion/exclusion criteria. As a result, at the time of informed consent, we do not know if a patient will be eligible to participate in the trial, so we will need to screen many more patients than we intend to enroll in order to meet our enrollment criteria. After a patient is determined to be eligible and is enrolled in the clinical trial, they must comply with the trial requirements and undergo periodic time-consuming tests, including a sleep test in a sleep lab. Not all patients who undergo screening will ultimately be eligible for enrollment in our clinical trials. Moreover, some of the enrolled participants may not comply with the requirements of the trial, thereby leading to poor or unusable data, or some may withdraw from the trial, which may compromise the results of the clinical trial.

We may not be able to initiate, continue and/or complete in a timely manner clinical trials if we are unable to locate and enroll a sufficient number of eligible patients within the planned recruitment period to participate in these trials as required by the applicable regulatory authorities in the United States, Europe and any other applicable jurisdictions.

Delays in subject enrollment or failure of trial subjects to continue to participate in a clinical trial may delay commencement or completion of the clinical trial, cause an increase in the costs of the clinical trial and delays, or result in the failure of the clinical trial. Patient enrollment in our clinical trials may be affected by many factors including:

● the fact that the Genio system is an implantable device requiring clinical trial subjects to undergo surgery;

● the existence of a competing device with long-term data supporting its safety and efficacy;

● clinicians' and patients' perceptions as to the potential advantages and risks of the Genio system in relation to other available therapies, including any new product candidates that may be approved for the indications we are investigating;

● the size and nature of the patient population;

● the severity of the disease under investigation;

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● the eligibility criteria for the trial in question;

● subject compliance with the trial protocol;

● the design of the clinical trial;

● the referral practices of physicians;

● limitations placed on enrollment by regulatory authorities or other bodies;

● the ability to monitor trial subjects adequately during and after treatment;

● the proximity and availability of clinical trial sites for prospective subjects;

● the approval of other devices or therapeutics for the target indications;

● efforts to facilitate timely enrollment;

● other clinical trials competing for the same target patients as those of our clinical trials; and

● the necessity for the trial subjects to dedicate their time to multiple visits to the clinic and/or sleep lab for tests, including a sleep test in a lab, forming part of the clinical trial.

Any difficulties in enrolling a sufficient number of subjects for any of our clinical trials, or any subjects withdrawing from the clinical trials or not complying with the trial protocols, could result in significant delays and could require us to abandon one or more clinical trials altogether. If our trial sites are restricted in performing elective surgeries or following up with their trial subjects, this may lead to missing information and may potentially impact clinical trial data quality and integrity. Enrollment delays and other issues with our clinical trials may result in increased research and development costs that may exceed the resources available to us and in delays to commercially launch the Genio system in target markets, if authorized for sale in such markets.

***Serious adverse events, or SAEs, or undesirable side effects or other unexpected properties of our product candidates may be identified during development that could delay or prevent the product candidate's marketing authorization or certification.***

As is the case with implantable medical devices generally, it is likely that there may be side effects and adverse events associated with the use of our Genio system or any future product candidate. Results of our clinical trials could reveal a high and unacceptable severity and prevalence of side effects or unexpected characteristics. SAEs or undesirable side effects caused by, or other unexpected properties of, our product candidates could cause us, an IRB or regulatory authorities or other bodies to interrupt, delay or halt clinical trials of one or more of our product candidates and could result in a more restrictive label or the delay or denial of marketing approval or certification by the FDA, Notified Bodies or comparable non-U.S. regulatory authorities. If any of our product candidates is associated with SAEs or undesirable side effects or has properties that are unexpected, we may need to abandon development or limit development of that product candidate to certain uses or subpopulations in which the undesirable side effects or other characteristics are less prevalent, less severe or more acceptable from a risk-benefit perspective. Many medical devices that initially showed promise in clinical trials or earlier stage testing have later been found to cause undesirable or unexpected side effects that prevented further development of the device. Additionally, if any of our future product candidates receives marketing authorization from the FDA, the side effects observed in clinical trials could result in a more restrictive label than we anticipate.

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#### Risks Related to Commercialization and Reimbursement
***Our product, including the Genio system, may become subject to unfavorable pricing regulations, third-party payor reimbursement practices or healthcare reform initiatives that could harm our business.***

The commercial success of the Genio system and any other product candidates we develop will depend substantially, both in the United States and abroad, on the extent to which coverage and reimbursement for our products and related procedures will be available from government health administration authorities, private health insurers and other third-party payors such as managed care and similar healthcare management organizations. Thus, our ability to commercialize the Genio system and any product candidates we develop will depend to a significant degree on which government authorities and third-party payors decide to cover our products and at what reimbursement levels. If reimbursement is not available, or is available only to a limited extent, we may not be able to successfully commercialize our products. Even if coverage is provided, the approved reimbursement amount may not be high enough to allow us to establish and maintain pricing sufficient to realize a meaningful return on our investment.

There is significant uncertainty related to government and other third-party payor coverage and reimbursement of newly approved medical devices. Regulatory approvals and pricing and reimbursement for new device products vary widely from country to country. Some countries require approval of the sale price of a device before it can be marketed. In many countries, the pricing review period begins after marketing authorization or certification is granted. In some non-U.S. markets, pricing remains subject to continuing governmental control even after initial approval is granted. As a result, we might obtain marketing authorization or certification for a product in a particular country but then be subject to price regulations that delay commercial launch of the product, possibly for lengthy time periods, which may negatively impact the revenues we are able to generate from the sale of the product in that country. Adverse pricing limitations may hinder our ability to recoup our investment in one or more product candidates, even if our product candidates obtain marketing authorization or certification.

The healthcare industry is acutely focused on cost containment, both in the United States and elsewhere. Government authorities and third-party payors have attempted to control costs by limiting coverage and the amount of reimbursement for particular medical products, which could affect our ability to sell our product candidates profitably. These payors may not view the Genio system or any of our other product candidates, if authorized for marketing, as reasonable and necessary for the treatment of patients or cost-effective, and coverage and reimbursement may not be available to our customers, or may not be sufficient to allow our product candidates, if authorized for marketing, to be sold on a competitive basis. Cost-control initiatives could cause us to decrease the price we might establish for products, which could result in lower than anticipated product revenues. Further, if the prices for our product candidates, if authorized for marketing, decrease or if governmental and other third-party payors do not provide adequate coverage or reimbursement, our prospects for revenue and profitability will suffer. Marketing authorization or certification of a product does not guarantee sufficient reimbursement to achieve commercial success.

There may also be delays in obtaining coverage and reimbursement for newly approved products, and coverage may be more limited than the indications for which the product is authorized by the FDA or comparable non-U.S. regulatory authorities. Moreover, eligibility for reimbursement does not imply that any product will be paid for in all cases or at a rate that covers our costs, including research, development, manufacture, sale and distribution. Reimbursement rates may vary, by way of example, according to the use of the product and the clinical setting in which it is used. Reimbursement rates may also be based on reimbursement levels already set for lower cost products or may be incorporated into existing payments for other services.

Obtaining and maintaining coverage and reimbursement can be a time-consuming process that could require us to provide supporting scientific, clinical and cost-effectiveness data for the use of our products. Increasingly, third-party payors are requiring higher levels of evidence of the benefits and clinical outcomes of new technologies and are challenging the prices charged. We may not be able to provide data sufficient to satisfy governmental and third-party payors that procedures using our products should be covered and reimbursed. We cannot be sure that coverage will be available for any product candidate that we commercialize and, if available, that the reimbursement rates will be adequate.

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Outside the United States, reimbursement levels vary significantly by country and by region, particularly based on whether the country or region at issue maintains a single-payor system. Annual healthcare budgets generally determine the number of therapeutic devices like the Genio system that will be paid for by the payor in these single-payor system countries and regions. Some countries or regions may require us to gather additional clinical data before granting coverage and reimbursement for our products. We are currently working with payors in the EU to obtain coverage and reimbursement approval in countries and regions where it makes economic sense to do so; however, we may not obtain such coverage, which could have a material adverse effect on our business, financial condition and results of operations and impair our ability to grow our business.

***We have limited experience marketing and selling our Genio system, and if we are unable to expand, manage and maintain our direct sales and marketing organization, we may not be able to generate revenue growth.***

We have only limited experience in marketing and selling our Genio system. To achieve commercial success, we will need to keep expanding our internal sales and marketing organization to commercialize the Genio system in markets that we will target directly, such as Germany, Austria, Switzerland and the United Kingdom. Expanding our sales and marketing team further will entail recruiting additional managerial, operational, financial and other employees, which is expensive and time-consuming and could delay product launches.

For example, as we increase marketing and commercialization activities for the Genio system in the United States, we intend to build a direct sales force. We have no experience marketing and selling the Genio system in the United States. Commercializing the Genio system in the U.S. market will require us to hire, develop, grow and retain a U.S. marketing and sales organization, which requires significant investment in recruiting and training. There is significant competition for marketing and sales personnel experienced in medical device sales. Once we hire such personnel, we expect to provide them with in-depth training, which can be lengthy, because it will require significant education for new marketing and sales representatives to achieve the level of clinical competency with the Genio system that physicians expect. Upon completion of training, our sales representatives will require lead time in the field to grow their network of accounts and achieve productivity levels we expect them to reach in each individual territory. If we are unable to attract, motivate, develop and retain a sufficient number of qualified sales personnel, and if our sales representatives do not achieve the productivity levels we expect them to reach, our revenue will not grow at the rate we expect, and our financial performance will suffer.

If the commercial launch of the Genio system in any jurisdiction for which we recruit a sales force and establish marketing capabilities is delayed or does not occur for any reason, we would have prematurely or unnecessarily incurred these commercialization expenses. This may be costly, and our investment would be lost if we cannot retain or reposition our sales and marketing personnel. In addition, our sales efforts may be hindered in target markets if we fail to develop and, as applicable, obtain marketing authorization for complementary products.

We may also decide to target certain markets indirectly via distributors or other arrangements. If we are unable to find suitable distribution partners, lose these distribution partners or if our distribution partners fail to sell our products in sufficient quantities, on commercially viable terms or in a timely manner, the commercialization of the Genio system could be materially harmed, which could prevent us from achieving or maintaining profitability.

***Hesitation to change or to undertake special training and economic, social, psychological and other concerns among physicians may limit general acceptance and adoption of the Genio system.***

Even if the Genio system receives marketing authorization or certification from the appropriate regulatory authorities or Notified Bodies, it may nonetheless fail to gain sufficient market acceptance by physicians, patients, third-party payors and others in the medical community. Our efforts to educate the medical community and third-party payors regarding the benefits of the Genio system are expected to require significant resources and may not be successful.

Acceptance of the Genio system will depend on physicians being convinced of the distinctive characteristics, clinical performance, benefits, safety and cost-effectiveness of the device and being prepared to undertake special training in certain cases. Furthermore, physicians will likely only adopt the Genio system if they determine, based on experience, clinical data, and published peer-reviewed journal articles that the Genio system is an attractive treatment solution, and that third-party payors, such as government programs and private health insurance plans, will provide coverage and adequate reimbursement for its use.

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The degree of market acceptance of the Genio system and any other product candidates we develop will depend on a number of social, psychological, economic and other factors and concerns, including:

● general conservatism about the adoption of new treatment practices and reluctance to switch their patients from existing therapies;

● personal history of adverse events and severe/serious adverse events;

● lack or perceived lack of long-term evidence supporting additional patient benefits;

● perceived liability risks associated with the use of new products and procedures;

● limited or lack of reimbursement and coverage within healthcare payment systems;

● costs associated with the purchase of new products and equipment;

● other procedures competing for physician time and attention;

● the fact that the Genio system contains an implantable device requiring surgery for implantation;

● the time commitment that may be required for special training;

● insufficient level of commercial attractiveness to physicians;

● the extent of ongoing support required by the clinician; and

● the extent of ongoing involvement of the patient in therapy.

***We may focus our financial and managerial resources on a particular market resulting in a failure to capitalize on markets that may be more profitable or for which there is a greater likelihood of success.***

Taking into account our current financial and managerial resources, we will have to carefully prioritize the order in which we address our target European markets for commercialization of the Genio system, based on parameters such as market size, market readiness, and competition, and then allocate our financial and managerial resources accordingly. In order to identify our primary target markets, we make projections on the number of people by target market. These projections are derived from a variety of sources, including, but not limited to, scientific literature, governmental statistics and market research, and are highly contingent on a number of variables that are difficult to predict and may prove to be too high. If as a result of these or other factors the market for the Genio system does not develop as currently anticipated, our ability to generate revenue could be materially adversely affected. Further, if we use our financial and managerial resources to promote a particular indication expansion that is not ultimately sufficiently commercially successful, this could result in a smaller population of patients who could benefit from the Genio system than we anticipate which would result in lower potential revenue.

#### Competition from medical device companies, medical device subsidiaries of large healthcare and pharmaceutical companies, and drug companies is intense and expected to increase.
The medical technology industry is highly competitive, subject to change and significantly affected by new product introductions and other activities of industry participants. Our competitors have historically dedicated and will continue to dedicate significant resources to promoting their products or developing new products or methods to treat moderate to severe OSA. We compete as a second line therapy in the OSA treatment market for patients with moderate to severe OSA.

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We consider other companies that have designed hypoglossal nerve stimulation technologies to treat OSA as direct competitors. We are aware of only one other marketed nerve stimulation device for the treatment of OSA, the Inspire Medical system marketed by Inspire Medical Systems, Inc., and one other nerve stimulation system for the treatment of OSA currently not actively commercialized in Europe from ImThera/ LivaNova PLC. The Inspire Medical system is currently the only other neuro stimulation system approved to treat moderate to severe OSA in the United States. Additionally, we also consider, as indirect competition, invasive surgical treatment options such as uvulopalatopharyngoplasty and maxillomandibular advancement surgery, and, to a lesser extent, mandibular advancement devices, which are primarily used in the treatment of mild to moderate OSA.

Glucagon-like peptide 1 (GLP-1s), a class of drug initially indicated for diabetes and obesity, gained popularity as a weight-loss drug beginning in 2023. In 2024, GLP-1s, also received a clinical indication for the treatment of OSA. Although we believe that there could be a benefit to our business as a result of GLP-1s, there can be no assurance of such benefit. If GLP-1s are successful in treating OSA, demand for our Genio system could be reduced and could have a material adverse effect on our sales, financial condition and results of operations.

Other competition could emerge from drug companies with products such as Apnimed's AD109 molecule. AD 109 is an investigational, first-in-class, once-daily oral pill designed to treat obstructive sleep apnea (OSA) by targeting the neurobiology of the upper airway muscles. It aims to prevent airway collapse during sleep, addressing a major unmet need for patients who cannot tolerate CPAP therapy. The product is in phase 3 clinical development.

In Europe, the Genio system is CE-Mark certified for use as a second-line therapy in the treatment of moderate to severe OSA in patients who do not tolerate, refused or failed positive airway pressure, or PAP, therapy. If one or more PAP device manufacturers successfully develop a PAP device that is better tolerated and demonstrates significantly higher compliance rates, or if improvements in other second-line therapies make them more effective, cost effective, easier to use or otherwise more attractive than the Genio system, these therapies could have a material adverse effect on our sales, financial condition and results of operations.

Companies against which we compete, directly or indirectly, may have competitive advantages with respect to primary competitive factors in the OSA treatment market, including:

● greater company, product and brand recognition;

● a more extensive body of clinical data demonstrating product reliability and durability;

● more effective marketing to and education of patients, physicians and sleep centers;

● greater product ease of use and patient comfort;

● more sales force experience and greater market access;

● better product support and service;

● more advanced technological innovation, product enhancements and speed of innovation;

● more effective pricing and revenue strategies;

● lower procedure costs to patients;

● more effective reimbursement teams and strategies;

● dedicated practice development; and

● more effective clinical training teams.

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The commercial availability of any approved competing product could potentially inhibit recruitment and enrollment in our clinical trials. We may successfully conclude our clinical trials and obtain final regulatory authorization or certification, and nevertheless may fail to compete against competitors or alternative treatments that may be available or developed for the relevant indication. Alternative treatments include devices and surgery, as well as potential pharmacological treatments, among others. New treatment options may emerge yielding clinical results better than or equal to those achieved with the Genio system, possibly at a lower cost. Emergence of such new therapies may inhibit our ability to develop and grow the market for the Genio system. Furthermore, new entrants into the markets in which we operate could also decide to more aggressively compete on price, requiring us to reduce prices to maintain market share.

***A pandemic, epidemic, or outbreak of an infectious disease could materially and adversely affect our business and our financial results and cause a disruption to our research, development and commercialization efforts.***

Public health crises such as pandemics or similar outbreaks could adversely impact our business. The extent to which a pandemic, such as the COVID-19 pandemic in recent years, or similar outbreak could impact our operations or those of our collaborators, vendors and other material business relations would depend on many factors which are highly uncertain and cannot be predicted at all, including the duration of the outbreak, the severity of the virus and the actions to contain it or treat its impact, among others.

#### Risks Related to Our Dependence on Third Parties and on Key Personnel
***A loss or degradation in performance of the suppliers on which we depend for services and components used in the production and assembly of the Genio system could have a material effect on our business, financial condition and results of operations.***

The Genio system requires customized components and services that are currently available from a limited number of sources. If these suppliers decide not to supply, are unable to supply, or if they provide us with components or services of insufficient quality, this could harm our reputation and business by affecting, for example, product availability and performance. Our suppliers might not be able or willing to continue to provide us with the components or services we need, at suitable prices or in sufficient quantity or quality. If any of our existing suppliers is unable or unwilling to meet our demand for components or services, or if the services or components that they supply do not meet quality and other specifications, clinical trials or sales of the Genio system could be delayed or halted, which could prevent us from achieving or maintaining profitability. For instance, we currently rely on a single source supplier for a number of critical components to the Genio system. We are seeking to qualify additional suppliers for certain of our components. The addition of a new supplier to the production process generally requires extensive evaluations, testing and regulatory approval, making it difficult and costly for us to diversify our exposure to single source suppliers. In addition, if we have to switch to a replacement supplier for any of our product components or for certain services required for the production and assembly of the Genio system such as, for example, sterilization of product components, or if we have to commence our own manufacturing to satisfy market demand, we may face delays, and the manufacturing and delivery of the Genio system could be interrupted for an extended period of time, which could delay completion of our clinical trials or commercialization and prevent us from achieving or maintaining profitability. Alternative suppliers may be unavailable, may be unwilling to supply, may not have the necessary regulatory approvals or certifications, or may not have in place an adequate quality management system. Furthermore, modifications to a service or component made by a third-party supplier could require new approvals or certifications from the relevant regulatory authorities before the modified service or component may be used.

If we are required to change the manufacturer of a critical component of our implant systems, we will be required to verify that the new manufacturer maintains facilities, procedures and operations that comply with our quality specifications and applicable regulatory requirements, which could further impede our ability to manufacture our implant systems in a timely manner. If we encounter demand for our system in excess of our inventory and we need to contract with these additional suppliers, we will face challenges in meeting that demand. Transitioning to a new supplier could be time-consuming and expensive, may result in interruptions in our operations and product delivery, could affect the performance specifications of our implant systems or could require that we modify the design of those systems. If the change in manufacturer results in a significant change to any product, new marketing authorizations or certification from the FDA or similar regulatory authority may be necessary before we implement the change, which could cause substantial delays. The occurrence of any of these events could harm our ability to meet the demand for our products in a timely or cost-effective manner.

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In addition, our suppliers may discontinue their supply of components or services upon which we rely before the end of the product life of the Genio system. The timing of a discontinuation in supply of components or services may not allow us sufficient time to develop and obtain any regulatory authorizations or certifications as required for replacement components or services before we exhaust our inventory. If suppliers discontinue their supply of components or services, we may have to pay premium prices to our suppliers to keep their production or service lines open or to obtain alternative suppliers, buy substantial inventory to last until the scheduled end of life of the Genio system or through such time as we have an alternative component developed and authorized by the regulatory authorities, or temporarily cease supplying the Genio system once our inventory of the affected component is exhausted.

Any of these interruptions to the supply of services or components could result in a substantial reduction in our available inventory and an increase in our production costs.

#### We may be unable to attract and retain management and other personnel we need to succeed.
Given our current state of development, reliance on the expertise and experience of our board of directors, management and other key employees, as well as contractors, in management, engineering, manufacturing, clinical and regulatory matters, sales and marketing, and other functions is crucial. The departure of any of these individuals without timely and adequate replacement or the loss of any of our senior management or other key employees would make it difficult for us to achieve our objectives in a timely manner, or at all. We might not be able to find and attract other individuals with similar levels of expertise and experience or similar relationships with commercial partners and other market participants. In addition, our competitive position could be compromised if a member of senior management transferred to a competitor.

We expect to expand our operations and grow our clinical development, manufacturing, administrative and commercial operations. This will require hiring a number of qualified clinical, scientific, commercial and additional administrative, sales and marketing personnel. Competition for skilled personnel is intense and may limit our ability to hire and retain highly qualified personnel on acceptable terms or at all. Competitors may have greater financial and other resources, different risk profiles and a longer history than we do. If we are unable to identify, attract, retain and motivate these highly skilled personnel, we may be unable to continue our development, commercialization or growth. Failure to retain or attract key personnel could have a material adverse effect on our business, results of operations, cash flows, financial condition and/or prospects.

***We rely, or may rely in the future, on third parties to provide critical advice and conduct our clinical trials, and those third parties may not perform satisfactorily, including failing to meet deadlines for the completion of clinical trials. Third-party performance failure may increase our developments costs, delay granting of regulatory authorizations or certifications or delay or prevent commercialization.***

We rely, and may rely in the future, on third parties to conduct certain clinical trials, perform data collection and analysis and provide marketing, manufacturing, regulatory advice and other services that are crucial to our business. In particular, our technology and product development activities or clinical trials conducted in reliance on third parties may be delayed, suspended, or terminated if the third parties do not devote a sufficient amount of time or effort to our activities or otherwise fail to successfully carry out their contractual duties or to meet regulatory obligations or expected deadlines; if we replace a third party; if the quality or accuracy of the data obtained by third parties is compromised due to their failure to adhere to clinical protocols, regulatory requirements, or for other reasons including the loss of data; or if the third party becomes bankrupt or enters into liquidation.

We may not always have the ability to control the performance of third parties in their conduct of their activities. Our agreements with these third parties generally allow the third party to terminate the agreement at any time, subject to standard notice terms. If these third parties do not successfully carry out their contractual duties or regulatory obligations or meet expected deadlines, or agreements with such third parties are terminated for any reason, we would be required to find a replacement third party to conduct the required activities. We may be unable to enter into a new agreement with another third party on commercially acceptable terms, if at all. Furthermore, if the quality or accuracy of the data obtained by the third party is compromised, or if data are otherwise lost, we would be required to repeat the affected trial. Third-party performance failures may therefore increase our development costs, delay our ability to obtain regulatory approval, and delay or prevent the commercialization of the Genio system in target markets. In addition, our third-party agreements usually contain a clause limiting such third party's liability, such that we may not be able to obtain full compensation for any losses that we may incur in connection with the third party's performance failures.

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Our reliance on these third parties for research and development activities will reduce our control over these activities but will not relieve us of our responsibilities. For example, we design our clinical trials and will remain responsible for ensuring that each of our clinical trials is conducted in accordance with the general investigational plan and protocols for the trial. Moreover, the FDA and other regulatory authorities require us to comply with GCP regulations and international standards relating to the conduct, recording and reporting the results of clinical trials to assure that data and reported results are credible and accurate and that the rights, integrity and confidentiality of trial participants are protected. Our reliance on third parties, over which we have limited control, to manage those operations does not relieve us of these responsibilities and requirements. Our failure or any failure by these third parties to comply with these regulations or to recruit a sufficient number of patients may require us to repeat clinical trials, which would delay the marketing authorization or certification process. Moreover, our business may be implicated if any of these third parties violates federal or state fraud and abuse or false claims laws and regulations or healthcare privacy and security laws. We also are required to register ongoing clinical trials and post the results of certain completed clinical trials on certain government-sponsored databases, such as ClinicalTrials.gov in the United States, within specified timeframes. Failure to do so can result in fines, adverse publicity and civil and criminal sanctions.

Furthermore, these third parties may also have relationships with other entities, some of which may be our competitors. If these third parties do not successfully carry out their contractual duties for any reason, meet expected deadlines or conduct our clinical trials in accordance with regulatory requirements or our stated protocols, we will not be able to obtain, or may be delayed in obtaining, regulatory approvals for our product candidates and will not be able to, or may be delayed in our efforts to, successfully commercialize our product candidates.

***Performance issues, service interruptions or price increases by our shipping carriers could adversely affect our business and harm our reputation and ability to supply our products on a timely basis.***

Expedited, reliable shipping is essential to our operations since the components of the Genio system are manufactured to our specifications by third-party suppliers in various jurisdictions, with assembly of such components in our facilities in Belgium or by our contract manufacturer in the United States. Expedited, reliable shipping is also essential to ship our products to our customers. As a result, we rely heavily on providers of transport services for reliable and secure point-to-point transport of the key components of the Genio system to our facility and for tracking of these shipments, as well as for reliable transport of our product to our customers. Should a carrier encounter delivery performance issues such as loss, damage or destruction of any components, it would be costly to replace such components in a timely manner and such occurrences, if they resulted in delays to the assembly and shipment of the completed Genio system to customers, may damage our reputation and lead to decreased demand for the Genio system and increased cost and expense to our business. In addition, any significant increase in shipping rates could adversely affect our operating margins and results of operations. Similarly, strikes, severe weather, natural disasters or other service interruptions affecting delivery services we use would adversely affect our ability to process orders for the Genio system on a timely basis.

***Our employees, independent contractors, principal investigators, contract research organizations, consultants or vendors may engage in misconduct or other improper activities, including noncompliance with regulatory standards and requirements.***

We are exposed to the risk that our employees, independent contractors, principal investigators, contract research organizations, consultants or vendors may engage in fraudulent or other illegal activity. Misconduct by these parties could include intentional, reckless and/or negligent conduct or disclosure of unauthorized activities to us that violates: FDA regulations, including those laws requiring the reporting of true, complete and accurate information to the FDA; manufacturing standards; federal and state healthcare fraud and abuse laws and regulations; or laws that require the true, complete and accurate reporting of financial information or data. In addition, sales, marketing and business arrangements in the healthcare industry are subject to extensive laws and regulations intended to prevent fraud, kickbacks, self-dealing and other abusive practices. These laws and regulations may restrict or prohibit a wide range of pricing, discounting, marketing and promotion, sales commission, customer incentive programs and other business arrangements. Activities subject to these laws also involve the improper use or misrepresentation of information obtained in the course of clinical trials or creating fraudulent data in our nonclinical studies or clinical trials, which could result in regulatory sanctions and serious harm to our reputation.

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It is not always possible to identify and deter misconduct by our employees and other third parties, and the precautions we take to detect and prevent this activity may not be effective in controlling unknown or unmanaged risks or losses or in protecting us from governmental investigations or other actions or lawsuits stemming from a failure to be in compliance with such laws or regulations. Additionally, we are subject to the risk that a person could allege such fraud or other misconduct, even if none occurred. If any such actions are instituted against us, and we are not successful in defending ourselves or asserting our rights, those actions could have a significant impact on our business, including the imposition of civil, criminal and administrative penalties, damages, monetary fines, possible exclusion from participation in Medicare, Medicaid and other federal healthcare programs, contractual damages, reputational harm, diminished potential profits and future earnings, and curtailment of our operations, any of which could adversely affect our business, financial condition, results of operations or prospects.

#### Risks Related to the Countries in which We Operate
***We are subject to the U.S. Foreign Corrupt Practices Act of 1977, the UK Bribery Act 2010, and other anti- corruption laws, as well as export control laws, import and customs laws, trade and economic sanctions laws and other laws governing our business and operations.***

Our operations are subject to anti-corruption laws, including the U.S. Foreign Corrupt Practices Act of 1977, or FCPA, the U.S. domestic bribery statute contained in 18 U.S.C. §201, the U.S. Travel Act; the UK Bribery Act 2010, or the Bribery Act; and other anti-corruption laws that apply in countries where we do business. The FCPA, the Bribery Act, and these other laws generally prohibit us and our employees and intermediaries from authorizing, promising, offering, or providing, directly or indirectly, a financial or other advantage to government officials or other persons to induce them to improperly perform a relevant function or activity (or reward them for such behavior). U.S. authorities that enforce the FCPA, including the Department of Justice, deem most healthcare professionals and other employees of foreign hospitals, clinics, research facilities and medical schools in countries with public healthcare or public education systems to be "foreign officials" under the FCPA. When we interact with foreign healthcare professionals and researchers in testing and marketing our products abroad, we must have policies and procedures in place sufficient to prevent us and agents acting on our behalf from providing any bribe, gift or gratuity, including excessive or lavish meals, travel or entertainment in connection with marketing our products and services or securing required permits and approvals such as those needed to initiate clinical trials in foreign jurisdictions. The FCPA also obligates companies whose securities are listed in the United States to comply with accounting provisions requiring the maintenance of books and records that accurately and fairly reflect all transactions of the corporation, including international subsidiaries, and the development and maintenance of an adequate system of internal accounting controls for international operations. The SEC is involved with the books and records provisions of the FCPA.

We are also subject to other laws and regulations governing our international operations, including regulations administered by the governments of the United Kingdom and the United States, and authorities in the EU, including applicable export control regulations, economic sanctions and embargoes on certain countries and persons, anti-money laundering laws, import and customs requirements and currency exchange regulations.

If we fail to comply with these laws and regulations, we could be subject to governmental investigations, prosecutions and penalties, including substantial fines and potential imprisonment of the individuals involved. Any such circumstances would carry the risk of substantial damage to our reputation for corporate integrity and would likely have a material adverse effect on our business and future prospects.

#### Risks Related to Manufacturing
***We may not be able to manufacture or outsource manufacturing of the Genio system in sufficient quantities, in a timely manner or at a cost that is economically attractive.***

Our revenue and other operating results will depend, in large part, on our ability to manufacture and sell the Genio system in sufficient quantities and quality, in a timely manner, and at a cost that is economically attractive.

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We expect to be required to significantly increase manufacturing volumes as clinical trials on the Genio system are expanded and the Genio system is commercialized. The capacity of our manufacturing facility in Milmort, Belgium, along with our contract manufacturer in the United States, is expected to cover the Genio Implantable Stimulator demand for 2026. Manufacturing of the Genio Activation Chip, the Genio Charging Unit and the Genio External Stimulator is mostly outsourced to third party contract manufacturing organizations. In order to support future demand for the Genio system, we announced an investment to further expand our manufacturing capacity to support worldwide growth by entering a nine-year lease of 2,000 square meters for a state of the art cleanroom. We expect this facility to be fully operational in 2027. Opening a new manufacturing facility could involve significant additional expenses, including for the construction of a new facility, the movement and installation of key manufacturing equipment, the modification of manufacturing processes and for the recruitment and training of new team members. In addition, we must also notify, and in most cases obtain approval from, regulatory authorities regarding any changes or modifications to our manufacturing facilities and processes, and the regulatory authorities might not authorize us to proceed or might delay the process significantly.

In addition, our current business expectation is that the cost of goods sold will decline over time as (i) internal efficiencies increase and (ii) the cumulative volume of Genio systems manufactured grows. However, we or our suppliers might not be able to increase yields and/or decrease manufacturing costs with time, and in fact costs may increase, which could prevent us from achieving or maintaining profitability.

***Our results of operations could be materially harmed if we are unable to accurately forecast customer demand for our Genio system and manage our inventory.***

To ensure adequate inventory supply of the Genio system in general and its components, we must forecast inventory needs and place orders with our suppliers based on our estimates of future demand for the Genio system and its components. To date, we have only commercialized the Genio system in limited quantities, mostly in Germany, and our ability to accurately forecast demand for our Genio system could be negatively affected by many factors, including failure to accurately manage our expansion strategy, product introductions by competitors, an increase or decrease in customer demand for the Genio system or for products of our competitors, failure to accurately predict customer acceptance of new products, unanticipated changes in general market conditions or regulatory matters, and weakening of economic conditions or consumer confidence in future economic conditions. Inventory levels in excess of customer demand may result in inventory write-downs or write-offs, which would cause our gross margin to be adversely affected and could impair the strength of the Genio brand. Conversely, if we underestimate customer demand for the Genio system, our third-party contract manufacturers may not be able to deliver products to meet our requirements, and this could result in damage to our reputation and customer relationships. In addition, if we experience a significant increase in demand, additional supplies of raw materials or additional manufacturing capacity may not be available when required on terms that are acceptable to us, or at all, or suppliers or third-party manufacturers might not be able to allocate sufficient capacity in order to meet our increased requirements, which could have an adverse effect on our ability to meet customer demand for the Genio system.

We intend to maintain sufficient levels of inventory in order to protect ourselves from supply interruptions. As a result, we will be subject to the risk that a portion of our inventory will become obsolete or expire, which could affect our earnings and cash flows due to the resulting costs associated with the inventory impairment charges and costs required to replace such inventory.

#### Risks Related to Legal and Regulatory Compliance Matters
***Our products and operations are subject to extensive government regulation and oversight both in the United States and abroad, and our failure to comply with applicable requirements could harm our business.***

Our Genio system is regulated as a medical device in the United States and other jurisdictions where our product is made available. We and our products are subject to extensive regulation in the United States and elsewhere, including by the FDA and its foreign counterparts in the jurisdictions where we operate. Such regulatory authorities regulate, among other things, with respect to medical devices: design, development and manufacturing; testing, labeling, content and language of instructions for use and storage; clinical trials; product safety; establishment registration, device listing or licensing; marketing, sales and distribution; product classification and market authorization requirements; recordkeeping procedures; advertising and promotion; recalls and field safety corrective actions; post-market surveillance, including reporting of deaths or serious injuries and malfunctions that, if they were to recur, could lead to death or serious injury; post-market studies, where required; and product import and export.

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The regulations to which we are subject are complex and have tended to become more stringent over time. Regulatory changes could result in restrictions on our ability to carry on or expand our operations, higher than anticipated costs or lower than anticipated sales.

Regulatory requirements and enforcement mechanisms vary by jurisdiction, and in the United States, the FDA enforces its regulatory requirements through, among other means, periodic announced or unannounced inspections. We do not know whether we or our contract manufacturers will be found substantially compliant with applicable regulations in connection with any future regulatory inspections. Failure to comply with applicable regulations could jeopardize our ability to sell the Genio system and any other product candidates, if they obtain marketing authorization, and result in enforcement actions such as: regulatory notices or warning letters; fines; injunctions; civil penalties; termination of distribution; recalls or seizures of products; delays in the introduction of products into the market; total or partial suspension of production; refusal to grant future marketing authorizations; withdrawals or suspensions of marketing authorizations, resulting in prohibitions on sales of our products; and in the most serious cases, criminal penalties.

***The Genio system is still unapproved in certain significant markets, and seeking and obtaining regulatory authorization or certification for active implantable medical devices can be a long, expensive and uncertain process.***

Applications for prior regulatory authorization in the countries where we intend to sell or market the Genio system and any other products we develop may require extensive non-clinical, clinical and performance testing. Such testing must be undertaken in accordance with the requirements of regulations established by the relevant regulatory agencies, which are complex and have become more stringent over time. We may be adversely affected by potential changes in government policy or legislation applicable to implantable medical devices. At the date of this Annual Report, we have obtained the regulatory authorizations required to market the Genio system and the Genio 2.1 system in the EU member states through CE-Marking, which is also valid in the European Economic Area, or EEA (which consists of the 27 EU member states plus Norway, Liechtenstein and Iceland) and accepted in the United Kingdom and Switzerland under certain conditions. We also commercialize the Genio system in certain Middle Eastern markets, subject to applicable local regulatory requirements, as well as in the United States through FDA approval.

***Even if we obtain marketing authorization or certification for our product candidates, the terms of such authorizations or certifications and ongoing regulation of our products may limit how we manufacture and market our products. Compliance with such requirements may involve substantial resources, which could materially impair our ability to generate revenue.***

Even if marketing authorization of a product candidate is received, commercial products and their manufacturers are subject to ongoing review and extensive regulation, including with respect to the manufacture, medical device reporting, import, export, registration, listing of devices and post-market surveillance of the product.

For example, in the United states, as a condition of our FDA approval, we are required to submit periodic reports to the FDA following marketing authorization, including annual reports and reports related to our post-approval studies. These reports include information about failures and certain adverse events associated with the device after its marketing authorization. Failure to submit such reports, or failure to submit the reports in a timely manner, could result in enforcement action by the FDA. Following its review of the periodic reports, the FDA may require additional regulatory action, where appropriate. As a result of these ongoing regulatory obligations,, we and our contract manufacturers will continue to expend time, money and effort in all areas of regulatory compliance, including manufacturing, production, product surveillance, and quality control.

If we are not able to comply with applicable post-market regulatory requirements, we could have one or more marketing authorizations or certifications for our products withdrawn, suspended or restricted by regulatory authorities, and our ability to market any future products could be limited. This could in turn adversely affect our ability to achieve or sustain profitability. Thus, the cost of compliance with post-market regulations may have a negative effect on our operating results and financial condition.

Our failure to comply with applicable regulatory requirements could result in enforcement action by regulatory authorities in the jurisdictions where we operate, which may include, among other things: regulatory notices or warning letters; fines, injunctions, consent decrees and civil penalties; recalls, termination of distribution, administrative detention, or seizure of our products; customer notifications; repair, replacement or refunds; operating restrictions or partial suspension or total shutdown of production; delays in or refusal to grant our requests for future regulatory approvals, certifications or other marketing authorizations, including for new products, new intended uses or modifications to existing products; withdrawals or suspensions of any granted marketing authorizations or certifications, resulting in prohibitions on sales of our products; or criminal prosecution. Any of these sanctions could have a material adverse effect on our reputation, business, financial condition and results of operations.

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In addition, regulatory authorities in the jurisdictions where we operate may change their regulatory requirements or authorization policies, adopt additional regulations or revise existing regulations, or take other actions, which may prevent or delay the authorization of any product candidate under development or impact our ability to modify any products already authorized for market on a timely basis. Such regulatory changes could impose additional requirements upon us that could delay our ability to obtain or maintain marketing authorizations, increase the costs of compliance or restrict our ability to commercialize our products.

***Failure to comply with the extensive regulations and approvals to which our manufacturing facilities and those of our third-party suppliers are subject may adversely affect our business.***

We currently manufacture the Genio system and have entered into relationships with third-party suppliers to manufacture and supply certain components of the Genio system. Our manufacturing practices and the manufacturing practices of our third-party suppliers are subject to ongoing regulation and oversight by regulatory authorities in the jurisdictions where we operate.

In the United States, the methods used in, and the facilities used for, the manufacture of medical devices must comply with the FDA's quality management system requirements, a complex regulatory scheme that covers the procedures and documentation of the design, testing, production, process controls, quality assurance, labeling, packaging, handling, storage, distribution, installation, and servicing of medical devices. Furthermore, we will be required to verify that our suppliers maintain facilities, procedures and operations that comply with our quality standards and applicable regulatory requirements. The FDA enforces its quality management system regulations through periodic announced or unannounced inspections of medical device manufacturing facilities, which may include the facilities of subcontractors. In other jurisdictions, regulatory authorities or designated conformity assessment bodies may conduct audits or other oversight activities to assess compliance with applicable manufacturing requirements.

Any failure to follow and appropriately document adherence to regulatory requirements (including maintaining an adequate quality management system in line with the most up-to-date standards and regulations) by us or our third-party suppliers may lead to significant delays in the availability of the Genio system for commercial sale or clinical trials, may result in the termination or suspension of a clinical trial, or may delay or prevent filing or approval or maintenance of marketing applications for the Genio system.

Regulatory authorities in the jurisdictions where we operate closely regulate compliance with all requirements governing medical device products, including requirements pertaining to marketing and promotion of devices in accordance with the provisions of the approved labeling and manufacturing of products in accordance with cGMP guidelines and requirements. Violations of such requirements may lead to investigations or enforcement actions under applicable laws and regulations. For example, in the United States, enforcement actions may allege violations of the FDCA and other statutes, including the False Claims Act and other federal and state healthcare fraud and abuse laws as well as state consumer protection laws.

Our failure to comply with all regulatory requirements, and later discovery of previously unknown adverse events or other problems with our products, manufacturers or manufacturing processes, may yield various results, including:

● litigation involving patients using our products;

● restrictions on our products, manufacturers or manufacturing processes;

● restrictions on the labeling or marketing of a product;

● restrictions on product distribution or use;

● requirements to conduct post-marketing studies or clinical trials;

● regulatory notices or warning letters;

● fines, restitution or disgorgement of profits or revenues;

● consent decrees;

● total or partial suspension or clinical hold of one or more of our clinical trials;

● total or partial suspension or withdrawal of regulatory approvals or authorizations;

● total or partial suspension of production or distribution;

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● delay of or refusal to approve pending applications or supplements to approved applications or to provide future market authorizations, certifications or approvals;

● mandatory communications with physicians and other customers about concerns related to actual or potential safety, efficacy, and other issues involving us;

● withdrawal of the products from the market;

● mandatory product recalls or seizure of products;

● damage to relationships with any potential collaborators;

● unfavorable press coverage and damage to our reputation; or

● injunctions or the imposition of civil or criminal penalties.

Any of the foregoing actions could significantly and negatively affect supply of the Genio system, if authorized for sale in applicable jurisdictions, and be detrimental to our reputation or result in significant costs or loss of revenues. If any of these events occurs, we could be exposed to product liability claims and we could lose customers and experience reduced sales and increased costs.

***Our ability to continue to market and sell our products in the EU, the EEA and other jurisdictions that recognize or rely on CE marking may be materially impaired if we do not maintain ongoing compliance with the requirements of the EU Medical Devices Regulation.***

On May 25, 2017, the EU Medical Devices Regulation 2017/745, or the MDR, entered into force, repealing and replacing Council Directive 93/42/EEC, or the Medical Devices Directive, and Council Directive 90/385/EEC, or the AIMD Directive. The MDR became fully effective on May 26, 2021. We obtained a CE Mark for the Genio 2.1 system under the MDR in July 2022.

Compliance with the MDR requires ongoing oversight, including periodic surveillance and review by Notified Bodies, and changes in regulatory requirements, interpretations or enforcement practices may affect the timing or cost of maintaining or modifying existing certifications or obtaining certifications for new products or product changes. The requirements under MDR may have an effect on the way we design and manufacture our products and product candidates and conduct our business in the EU and EEA. We cannot exclude the possibility of unexpected regulatory hurdles or delays in connection with ongoing MDR compliance or future product modifications. As a result product modifications or new product certifications may be subject to additional review requirements or extended timelines which could adversely affect our ability to introduce new products or implement change to existing products which could impact the growth of our business.

The EU-UK Trade and Cooperation Agreement, or TCA, came into effect on January 1, 2021. As a result of Brexit, the regulatory regime for medical devices in the UK differs from that in the EU. CE-markings will continue to be recognized in the UK, and certificates issued by EU-recognized Notified Bodies will be valid in the UK, until the earlier of June 30, 2028 or the expiration of the certificate for devices compliant with the MDD or AIMDD or until June 30, 2030 for devices compliant with the MDR. Following the end of the applicable transition periods, medical devices placed on the UK market will require the UK Conformity Assessed, or UKCA, marking. In contrast, UKCA marking and certificates issued by UK Notified Bodies will not be recognized on the EU market.

The TCA does provide for cooperation and exchange of information in the area of product safety and compliance, including market surveillance, enforcement activities and measures, standardization related activities, exchanges of officials, and coordinated product recalls (or other similar actions). For medical devices that are locally manufactured but use components from other countries, the "rules of origin" criteria will need to be reviewed. Depending on which countries products will be ultimately sold in, manufacturers may start seeking alternative sources for components if this would allow them to benefit from no tariffs. Under the Windsor Framework, an agreement between the UK government and the European Commission, the rules for placing medical devices on the Northern Ireland market differ from those in the UK. These modifications may have an effect on the way we design and manufacture products and we conduct our business in these countries.

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#### Compliance with regulations for quality systems for medical device companies is difficult, time consuming and costly.
We have developed and maintain a quality management system for medical devices intended to ensure that our design, manufacturing and quality system activities comply with applicable regulatory requirements. The system is designed to comply with the applicable regulatory requirements in the jurisdictions where our products are available, including the FDA's Quality Management System Regulation (QMSR) in the United States and the requirements of the MDR in the European Union, and is aligned with the international standard ISO 13485 which is widely used to support compliance with quality management system requirements in various jurisdictions.

Compliance with regulations for quality management systems for medical device companies is time consuming and costly, and there are changes in such regulations from time to time. For example, quality management system requirements and applicable standards, including ISO 13485:2016, may be updated or interpreted differently over time. While management believes that we are compliant with existing quality management system regulations for medical device companies as of the date of this Annual Report, it is possible that we may be found to be noncompliant with new or existing regulations in the future. In addition, we may be found to be noncompliant as a result of future changes in, or interpretation of, the regulations for quality systems. If we do not achieve compliance or subsequently become noncompliant, regulatory authorities may require that we take appropriate action to address non-conformance issues identified in a regulatory audit, and may, if we do not take such corrective actions in a timely manner, withdraw marketing authorizations or certifications, or require product recall or take other enforcement action.

Our external vendors must, in general, also comply with the quality systems requirements, and may be expected to conform to ISO 13485 or equivalent standards, depending on the jurisdiction and scope of services they provide. Any of our external vendors may become noncompliant with quality systems regulations or applicable quality standards, which could result in enforcement action by regulatory authorities, including, for example a warning letter from the FDA and/or a requirement to withdraw from the market, suspend distribution, or restrict the export or use of products manufactured by one or more of our vendors.

Any change or modification to a device (including changes to the manufacturing process) may require supplemental filings to regulatory authorities or new submissions for marketing authorization or certification (depending on the jurisdiction) and must be made in compliance with appropriate quality system regulations, which may cause interruption to or delays in the marketing and sale of our products. Regulations and laws regarding the manufacture and sale of medical devices are subject to future changes, as are administrative interpretation and policies of regulatory agencies. If we fail to comply with such laws and regulations where we would intend to market the Genio system, we could be subject to enforcement action including recall of our device, withdrawal of approval, authorization, certification or clearance and civil and criminal penalties. If any of these events occur, it may materially and adversely affect our business, financial condition, results of operations and prospects.

***Active implantable medical devices such as the Genio system carry risks associated with the surgical procedure for implant or removal of the device, use of the device, or the therapy delivered by the device.***

The Genio system is a medical device with complex electronic circuits and software and includes a component that is implanted in the patient through a surgical procedure. It is not possible to design and build electronic implantable medical devices that are 100% reliable, since all electronic devices carry a risk of failure. Furthermore, all surgical procedures carry risks, and the effectiveness of any medical therapy varies between patients. The consequences of failure of the Genio system include complications arising from product use and associated surgical procedures and could range from minor to life-threatening effects and even death.

All medical devices have associated risks. Regulatory authorities regard active implantable medical devices, or AIMDs, as the highest risk category of medical devices and, accordingly, AIMDs are subject to a high level of scrutiny when seeking regulatory approval or other marketing authorization. As a result, the Genio system is subject to extensive regulatory review, and failure to meet applicable regulatory requirements could delay, suspend or prevent continued marketing of the device. Although the Genio system has been permitted to bear the CE-Mark under the MDR, continued compliance is required and may be affected by changes in regulatory expectations, interpretations or enforcement practices.

Medical devices authorized for marketing in the European Union need to comply with the general safety and performance requirements laid down in the MDR and, in particular, demonstrate that they are designed and manufactured in such a way that it will not compromise the clinical condition or safety of patients, or the safety and health of users and others (that the potential benefits outweigh potential risks). In addition, medical devices must achieve the performance intended by the manufacturer and be designed, manufactured, and packaged in a suitable manner.

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Devices authorized first in the European Union may be associated with an increased risk of post-marketing safety alerts and recalls. On the other hand, before FDA premarket approval of a medical device in the United States, a device must be shown to be safe and effective for its intended use. The risks associated with medical devices and the therapy delivered by them, include, among others, risks associated with any surgical procedure, such as infection, allergic reaction, and consequences of anesthesia and risks associated with any implantable medical device such as device movement, electromagnetic interference, device failure, tissue damage including nerve damage, pain and psychological side effects associated with the therapy or the surgical procedure.

Adverse events associated with these risks may lead some patients to blame us, the physician or other parties for such occurrences. This may result in product liability lawsuits, medical malpractice lawsuits, investigations by regulatory authorities, adverse publicity, criminal charges or other harmful circumstances for us. Any of those circumstances may have a material adverse effect on our ability to conduct our business, to continue selling the Genio system, to achieve revenue objectives, or to develop future products.

***If our products are defective, or otherwise pose safety risks, the relevant governmental authorities could require their recall, or we may need to initiate a recall of our products voluntarily.***

AIMDs are characterized by a complex manufacturing process, requiring adherence to demanding product specifications. The Genio system uses many disciplines including electrical, mechanical, software, biomaterials, and other types of engineering. Device failures discovered during the clinical trial phase may lead to suspension or termination of the trial. In addition, device failures and malfunctions may result in a recall of the product, which may relate to a specific manufacturing lot or may affect all products in the field. Recalls may occur at any time during the life cycle of a device after regulatory authorization has been obtained for the commercial distribution of the device. For example, engineers employed by us undertaking development or manufacturing activities may make an incorrect decision or make a decision during the engineering phase without the benefit of long-term experience, and the impact of such wrong decisions may not be felt until well into a product's life cycle.

Regulatory authorities in the jurisdictions where we market devices have the authority to require the recall of commercialized medical devices in the event of material deficiencies or defects in design or manufacture of a device or in the event that a device poses an unacceptable risk to health. For example, in the United States, the FDA's authority to require a recall must be based on a finding that there is reasonable probability that the device could cause serious injury or death. We may also choose to voluntarily recall any of our devices if any material deficiency or risk associated with such devices is found. A government-mandated or voluntary recall by us could occur as a result of an unacceptable risk to health, component failures, malfunctions, manufacturing defects, labeling or design deficiencies, packaging defects, post-market safety findings, or other deficiencies or failures to comply with applicable regulations. Product defects or other errors may occur in the future.

Depending on the corrective action we take to redress a product's deficiencies or defects, regulatory authorities may require, or we may decide, that we will need to obtain new marketing authorizations for the device before we may market or distribute the corrected device. Seeking such authorizations may delay our ability to replace the recalled devices in a timely manner. Moreover, if we do not adequately address problems associated with our devices, we may face additional regulatory enforcement action, which, depending on the jurisdiction, may include warning letters, product seizure, injunctions, administrative penalties or civil or criminal fines.

Companies are required to maintain certain records of recalls and corrections, even if they are not reportable to the applicable regulatory authorities or certification bodies. We may initiate voluntary withdrawals or corrections for our products in the future that we determine do not require notification; however, if the regulatory authority disagrees with our determinations, it could require us to report those actions as recalls and we may be subject to enforcement action. A future recall announcement could also harm our reputation with customers, potentially lead to product liability claims against us and negatively affect our sales. Any corrective action, whether voluntary or involuntary, as well as defending ourselves in a lawsuit, will require the dedication of our time and capital, distract management from operating our business and may harm our reputation and financial results.

Recalls of the Genio system would divert managerial and financial resources and could result in damaged relationships with regulatory authorities and lead to loss of market share to competitors. In addition, any product recall may result in irreparable harm to our reputation. Any product recall could impair our ability to produce our devices in a cost-effective and timely manner in order to meet customer demand. We may also be required to bear other costs or take other actions that may have a negative impact on future revenue and could prevent us from achieving or maintaining profitability.

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***The misuse or off-label use of our product candidates may harm our reputation in the marketplace, result in injuries that lead to product liability suits or result in costly investigations, fines or sanctions by regulatory bodies if we are deemed to have engaged in the promotion of these uses, any of which could be costly to our business.***

Any marketing authorization or certification we may receive for our products will be limited to specified indications for use, and we must also comply with requirements concerning advertising and promotion of the system. Promotional communications with respect to medical devices are subject to a variety of legal and regulatory restrictions and must be consistent with the device's authorized intended use, data from any clinical trials, and established specifications. Thus, we will not be able to promote the Genio system for indications or uses for which it is not authorized.

We train our marketing personnel and direct sales force not to promote the Genio system for uses outside of the authorized indications for use, known as "off-label uses." We cannot, however, prevent a physician from using our devices off-label, when in the physician's independent professional medical judgment he or she deems it appropriate. There may be increased risk of injury to patients if physicians attempt to use our devices off-label, which could harm our reputation in the marketplace among physicians and patients.

If a regulatory authority determines that our promotional materials or training constitute promotion of an off-label use, it could request that we modify our training or promotional materials or subject us to regulatory or enforcement actions. For example, in the United States, such actions by the FDA may include the issuance or imposition of a warning letter or an untitled letter (which is used to notify regulated entities of violations that do not necessitate a warning letter) injunction, seizure, civil fine or criminal penalties. It is also possible that other federal, state or other enforcement authorities might take action under other regulatory authority, such as false claims laws, if they consider our business activities to constitute promotion of an off-label use, which could result in significant penalties, including, but not limited to, criminal, civil and administrative penalties, damages, fines, disgorgement, exclusion from participation in government healthcare programs and the curtailment of our operations.

In addition, physicians may misuse our products or use improper techniques if they are not adequately trained, potentially leading to injury and an increased risk of product liability. Although we provide training and educational materials to healthcare providers regarding the use of our devices, such training may be insufficient, inconsistently applied, or not followed in practice. If our devices are misused or used with improper technique, we may become subject to costly litigation by our customers or their patients. Product liability claims could divert management's attention from our core business, be expensive to defend and result in sizeable damage awards against us that may not be covered by insurance.

***We face the risk of product liability claims that could be expensive, divert management's attention and harm our reputation and business. We may not be able to maintain adequate product liability insurance.***

Our business exposes us to the risk of product liability claims that are inherent in the testing, manufacturing and marketing of medical devices. The Genio system is designed to be implanted in the body and to affect important bodily functions and processes. As with any other complex medical device, there exists the reasonable certainty that, over time, one or more components of some Genio systems will malfunction. As a medical device manufacturer, we are exposed to the product liability claims arising from the Genio system failures and malfunctioning, product use and associated surgical procedures. This risk exists even if the Genio system is certified or authorized for commercial sale by regulatory authorities or Notified Bodies and manufactured in facilities licensed and regulated by the applicable regulatory authority or Notified Body. The medical device industry has historically been subject to extensive litigation over product liability claims, and we may face product liability suits if the Genio system causes, or merely appears to have caused, patient injury or death. In addition, an injury that is caused by the activities of our suppliers, such as those who provide us with components and raw materials, may be the basis for a claim against us. Product liability claims may be brought against us by patients, healthcare providers or others selling or otherwise being exposed to the Genio system, among others. If we cannot successfully defend ourselves against product liability claims, we will incur substantial liabilities and reputational harm. In addition, regardless of merit or eventual outcome, product liability claims may result in one or more of the following:

● costs of litigation;

● distraction of management's attention from our primary business;

● the inability to commercialize the Genio system or new products;

● decreased demand for the Genio system;

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● damage to our reputation;

● product recalls or withdrawals from the market;

● withdrawal of clinical trial participants;

● substantial monetary awards to patients or other claimants; or

● loss of sales.

While we may attempt to manage our product liability exposure by proactively recalling or withdrawing from the market any defective products, any recall or market withdrawal of our products may delay the supply to our customers and may impact our reputation. We may not be successful in initiating appropriate market recall or market withdrawal efforts that may be required in the future and these efforts may not have the intended effect of preventing product malfunctions and the accompanying product liability that may result. Such recalls and withdrawals may also be used by our competitors to harm our reputation for safety or be perceived by patients as a safety risk when considering the use of our products, either of which could have a material adverse effect on our business, financial condition and results of operations.

Although we maintain product liability and clinical trial liability insurance at levels we believe are appropriate, this insurance is subject to deductibles and coverage limitations. Our current product liability insurance may not continue to be available to us on acceptable terms, if at all, and, if available, coverage may not be adequate to protect us against any future product liability claims. If we are unable to obtain insurance at an acceptable cost or on acceptable terms or otherwise protect against potential product liability claims, we could be exposed to significant liabilities, including claims for amounts in excess of insured liabilities. As of the date of the Annual Report, there are no product liability claims against us.

#### We bear the risk of warranty claims on the Genio system.
We bear the risk of warranty claims on the Genio system. We may not be successful in claiming recovery under any warranty or indemnity provided to us by our suppliers or vendors in the event of a successful warranty claim against us by a customer, and any such recovery from a vendor or supplier may be inadequate to fully compensate us. In addition, warranty claims brought by our customers related to third-party components may arise after our ability to bring corresponding warranty claims against such suppliers expires, which could result in costs to us. As of the date of the Annual Report, there are no warranty claims against us.

***We are and will be subject to healthcare fraud and abuse laws and other laws applicable to our business activities and if we are unable to comply with such laws, we could face substantial penalties.***

We are subject to various federal, state and local laws pertaining to healthcare fraud and abuse laws, including anti-kickback, false claims and transparency laws. Many EU member states have adopted specific anti-gift statutes that further limit commercial practices for medical devices, in particular vis-à-vis healthcare professionals and organizations. Additionally, there has been a recent trend of increased regulation of payments and transfers of value provided to healthcare professionals or entities. In addition, many EU member states have adopted national "Sunshine Acts" which impose reporting and transparency requirements (often on an annual basis) on medical device manufacturers, similar to the requirements in the United States. For instance, pursuant to the Belgian Act of December 18, 2016 and its implementing Royal Decree of June 14, 2017, which entered into force on June 23, 2017, manufacturers of medical devices are required to document and disclose all direct or indirect premiums and benefits granted to healthcare professionals, healthcare organizations and patient organizations with a practice or a registered office in Belgium. Also, under Article 10 of the Belgian Act of March 25, 1964, it is prohibited (subject to limited exceptions) in the context of the supply of medical devices to offer or grant any advantage or benefit in kind to amongst others healthcare professionals and healthcare organizations. In addition, certain countries also mandate implementation of commercial compliance programs.

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Healthcare laws and regulations in the United States may constrain the business or financial arrangements and relationships through which we research, market, sell and distribute any products for which we obtain marketing approval. The healthcare laws and regulations that may affect our ability to operate include, but are not limited to:

● the U.S. federal Anti-Kickback Statute prohibits, among other things, persons from knowingly and willfully soliciting, offering, receiving or providing remuneration, directly or indirectly, in cash or in kind, to induce or reward, or in return for, either the referral of an individual for, or the purchase, order or recommendation of, any good or service, for which payment may be made under a federal healthcare program such as Medicare and Medicaid. A person or entity does not need to have actual knowledge of the statute or specific intent to violate it to have committed a violation;

● the U.S. federal False Claims Act imposes criminal and civil penalties, including civil whistleblower or qui tam actions, against individuals or entities for, among other things, knowingly presenting, or causing to be presented false or fraudulent claims for payment by a federal government program, or making a false statement or record material to payment of a false claim or avoiding, decreasing or concealing an obligation to pay money to the federal government. In addition, the government may assert that a claim including items or services resulting from a violation of the federal Anti- Kickback Statute constitutes a false or fraudulent claim for purposes of the federal False Claims Act. Private individuals can bring False Claims Act "qui tam" actions, on behalf of the government and such individuals, commonly known as "whistleblowers," may share in amounts paid by the entity to the government in fines or settlement;

● the U.S. federal Health Insurance Portability and Accountability Act of 1996, or HIPAA, as amended by the Health Information Technology for Economic and Clinical Health Act, or HITECH, imposes criminal and civil liability for executing a scheme to defraud any healthcare benefit program and also imposes obligations, including in some circumstances mandatory contractual terms, with respect to safeguarding the privacy, security and transmission of individually identifiable health information;

● the U.S. federal false statements statute prohibits knowingly and willfully falsifying, concealing or covering up a material fact or making any materially false statement in connection with the delivery of or payment for healthcare benefits, items or services;

● the U.S. federal transparency requirements under the Physician Payments Sunshine Act require manufacturers of FDA-authorized drugs, devices, biologics and medical supplies covered by Medicare or Medicaid to report, on an annual basis, to the Centers for Medicare and Medicaid Services information related to payments and other transfers of value to physicians, certain advanced non-physician healthcare practitioners, and teaching hospitals as well as ownership and investment interests held by physicians and their immediate family members; and

● analogous foreign and state laws and regulations such as state anti-kickback and false claims laws and analogous non-U.S. fraud and abuse laws and regulations, may apply to sales or marketing arrangements and claims involving healthcare items or services reimbursed by non-governmental third-party payors, including private insurers, and some state laws require medical device companies to comply with the device industry's voluntary compliance guidelines and the relevant compliance guidance promulgated by the federal government in addition to requiring device manufacturers to report information related to payments to physicians and other healthcare providers or marketing expenditures. State and non-U.S. laws, including the EU General Data Protection Regulation, or GDPR, also govern the privacy and security of health information, many of which differ from each other in significant ways and often are not preempted by HIPAA, thus complicating compliance efforts.

Efforts to ensure that our business arrangements with third parties will comply with applicable healthcare laws and regulations will involve substantial costs. It is possible that governmental authorities will conclude that our business practices, including our financial arrangements with physicians, some of whom receive compensation in the form of stock options, which could be viewed as influencing the purchase of or use of our products in procedures they perform and may not comply with current or future statutes, regulations or case law involving applicable fraud and abuse or other healthcare laws and regulations.

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Any action brought against us for violations of these laws or regulations, even if successfully defended, could cause us to incur significant legal expenses and divert our management's attention from the operation of our business. We may be subject to private qui tam actions brought by individual whistleblowers on behalf of the federal or state governments, with potential liability under the federal False Claims Act including mandatory treble damages and significant per-claim penalties. If our operations are found to be in violation of any of these laws or any other governmental regulations that may apply to us, we may be subject to significant civil, criminal and administrative penalties, damages, fines, imprisonment, exclusion of products from government funded healthcare programs, such as Medicare and Medicaid, and the curtailment or restructuring of our operations. If any of the physicians or other healthcare providers or entities with whom we expect to do business is found to be not in compliance with applicable laws, they may be subject to criminal, civil or administrative sanctions, including exclusions from government funded healthcare programs. Any of the foregoing consequences will negatively affect our business, financial condition and results of operations.

#### Healthcare policy changes, including legislation or regulations aiming to reform the U.S. healthcare system, could harm our business, financial condition and results of operations.
In the United States, there have been and continue to be a number of legislative initiatives to contain healthcare costs. Federal and state lawmakers regularly propose and, at times, enact legislation that would result in significant changes to the healthcare system, some of which are intended to contain or reduce the costs of medical products and services. Future legislative and regulatory proposals to further reform healthcare or reduce healthcare costs may prevent, limit or delay regulatory authorization of our product candidates or coverage or reimbursement for such product candidates, if approved, or even lower reimbursement for the procedures associated with the use of such product candidates. More broadly, such future legislation or regulation may materially impact the ability of the FDA and other regulatory agencies to operate as they have historically operated. The cost containment measures that payors and providers are instituting and the effect of any healthcare reform initiative implemented in the future could impact our revenue from the sale of our products. We cannot be sure whether additional legislative changes will be enacted, or whether any of the FDA's regulations, guidance or interpretations will be changed, or what the impact of such changes on the agency and its scientific review staff, if any, may be.

In December 2022, the U.S. Congress enacted the Consolidated Appropriations Act for 2023, an omnibus appropriations bill, which included amendments to the FDCA under the Food and Drug Omnibus Reform Act of 2022, or FDORA. In addition to the requirement that sponsors of pivotal trials submit diversity action plans for pivotal trials (see "Government Regulation—Regulatory Landscape in the United States—Device Clinical Studies"), FDORA included new requirements for cyber devices, defined as any medical device that is or includes software that is validated, installed, or authorized by the manufacturer; can connect to the internet; and may be vulnerable to cybersecurity threats. Under the FDORA amendments to the FDCA, any application for marketing authorization of the cyber device must include a software bill of materials and a cybersecurity plan describing the methods by which the manufacturer will monitor, identify and address cybersecurity vulnerabilities. Any failure by a cyber device manufacturer to comply with applicable cybersecurity requirements is considered a violation of the FDCA and will subject the manufacturer to enforcement actions and possibly legal sanctions.

We expect additional state and federal healthcare policies and reform measures to be adopted in the future, any of which could limit reimbursement for healthcare products and services or otherwise result in reduced demand for our product candidates, if approved, or additional pricing pressure and have a material adverse effect on our industry generally and on our customers. We cannot predict what other healthcare programs and regulations will ultimately be implemented at the federal or state level or the effect of any future legislation or regulation in the United States may negatively affect our business, financial condition and results of operations. The continuing efforts of the government, insurance companies, managed care organizations and other payors of healthcare services to contain or reduce costs of healthcare may adversely affect:

● our ability to set a price that we believe is fair for the Genio system;

● our ability to generate revenue and achieve or maintain profitability; and

● the availability of capital.

Any changes of, or uncertainty with respect to, future coverage or reimbursement rates could affect demand for our product candidates, if approved, which in turn could impact our ability to successfully commercialize our device and could have a material adverse effect on our business, financial condition and results of operations.

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***We are subject to, or may in the future become subject to, federal, state, and foreign laws and regulations imposing obligations on how we collect, store, use and process information collected from or about patients or their procedures using our products. Our actual or perceived failure to comply with such obligations could harm our business. Ensuring compliance with such legal requirements could also impair our efforts to maintain and expand our customer base, and thereby decrease our revenue.***

The collection and use of personal (health) data in the European Union and European Economic Area, or EEA, is governed by the GDPR. Since we are located in the European Union, we are subject to the GDPR when we process personal data from anywhere in the world for purposes of our business in the EEA. The territorial reach of the GDPR also includes the activities of businesses located outside of the EEA that relate to the businesses' provision of goods or services to residents in the EEA, or monitoring the behavior of people in the EEA. We are therefore also subject to the GDPR even where our data processing activities take place outside of the European Union and relate only to our business outside of the European Union to the extent that such activities involve personal data of individuals located in the European Union and relate to our offer of goods or services to them, or to our monitoring of their behavior. The GDPR imposes strict requirements on controllers and processors of personal data, including special protections for "sensitive personal data" which includes genetic data and data concerning one's health and we may be required to put in place additional mechanisms to ensure compliance with such data protection rules. This may be onerous and may interrupt or delay our development activities, and adversely affect our business, financial condition, results of operations and prospects.

On a general note, failure to comply with the GDPR could result in penalties for noncompliance (including possible fines of up to the greater of €20 million or 4% of our global annual turnover for the preceding financial year for the most serious violations, as well as the right to compensation for financial or non-financial damages claimed by individuals under Article 82 of the GDPR). If any of these events were to occur, our business and financial results could be significantly disrupted and adversely affected.

The GDPR also regulates the transfer of personal data to third countries. Such transfers are authorized to the extent they meet the conditions laid down in the GDPR for such transfers. The GDPR provides for different means for personal data to be legally transferred to third countries, including adequacy decisions, appropriate safeguards such as standard contractual clauses, and binding corporate rules. Certain legal developments in Europe have created complexity and uncertainty regarding such transfers, especially when it comes to transfers to the United States of America.

Navigating transfers of personal data to US-based organizations has not been easy in recent years, following legal challenges brought against several international data transfer instruments set forth under the GDPR. On July 16, 2020, for instance, the Court of Justice of the European Union, or CJEU, invalidated, by means of the so-called Schrems II-judgment, the EU-U.S. Privacy Shield Framework, or the Privacy Shield, under which personal data could be transferred from the EEA to U.S. entities who had self-certified under the Privacy Shield scheme. US laws were considered falling short of guaranteeing EU individuals an essentially equivalent level of data protection as in the EU due to far-reaching possibilities of surveillance that existed under US national security laws. Following the Schrems-II judgment, organizations transferring personal data to the US relied on standard contractual clauses. While the CJEU upheld the adequacy of the standard contractual clauses (a standard form of contract approved by the European Commission as an adequate third country personal data transfer mechanism and potential alternative to the Privacy Shield), it made clear that reliance on such clauses alone may not necessarily be sufficient in all circumstances. Uncertainties were lifted with the adoption by the European Commission of a new adequacy decision relating to transfers of personal data to organizations participating in the Data Privacy Framework. On July 10, 2023, the European Commission adopted an adequacy decision for a new mechanism for transferring data from the EU to the United States, or the EU-U.S. Data Privacy Framework, which provides EU individuals with several new rights, including the right to obtain access to their data, or obtain correction or deletion of incorrect or unlawfully handled data, and allows U.S. companies to self-certify to the U.S. Department of Commerce their compliance with a set of agreed privacy principles in order to freely receive EU personal data. The adequacy decision followed the signing of an executive order introducing new binding safeguards to address the points raised in the Schrems II-judgment. Notably, the new obligations were geared to ensure that data can be accessed by U.S. intelligence agencies only to the extent necessary and proportionate and to establish an independent and impartial redress mechanism to handle complaints from Europeans concerning the collection of their data for national security purposes. The European Commission will continually review developments in the United States along with its adequacy decision. Adequacy decisions can be adapted or even withdrawn in the event of developments affecting the level of protection in the applicable jurisdiction. In this respect it must be noted that several privacy organizations are calling for such a withdrawal, and it seems that several changes undertaken by the Trump administration could lead to a degraded function of the EU-US Data Privacy Framework so that it is uncertain whether the CJEU would uphold it in a Schrems III-like case. New challenges of the EU-US Data Privacy Framework should be expected too, despite the General Court's judgment of September 3, 2025 rejecting the first legal challenge brought against the adequacy decision.

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In addition, the GDPR provides that European Union member states may further "implement" the GDPR in certain areas; in respect of the processing of genetic, biometric or health data, the GDPR for instance allows for member states to maintain or introduce further conditions, including limitations, which leads to additional uncertainties. By means of example, the Belgian legislator has made use of this option and makes the processing of such types of personal data subject to additional requirements (Art. 9 of the GDPR Act of 30 July 2018).

While in early 2025, the European Commission withdrew its proposed Regulation on Privacy and Electronic Communications, or ePrivacy Regulation, the 2019 Planet49 judgment of the CJEU and regulators' recent guidance and increased enforcement activity are driving increased attention to cookies and other tracking technologies. Some regulators have started to enforce the strict approach in recent guidance; the Belgian Data Protection Authority for instance has been proactively looking for cookie infringements on (press) websites and placed those websites under scrutiny in recent case law. Moreover, the EDPB has published the Cookie Banner Taskforce Report, which identifies common minimum thresholds for the data protection authorities in relation to cookies. Compliance with existing and future rules concerning cookies and other tracking technologies could lead to substantial costs, require significant systems changes, limit the effectiveness of our marketing activities, divert the attention of our technology personnel, adversely affect our margins, increase costs and subject us to additional liabilities. Regulation of cookies and similar technologies may lead to broader restrictions on our marketing and personalization activities and may negatively impact our efforts to understand users.

Further, in March 2017, the United Kingdom formally notified the European Council of its intention to leave the European Union pursuant to Article 50 of the Treaty on European Union. The United Kingdom ceased to be a European Union Member State on January 31, 2020, but enacted a Data Protection Act substantially implementing the GDPR, effective in May 2018, which was further amended to align more substantially with the GDPR following Brexit. Currently, the data protection laws of the UK and the EU remain closely aligned, which means that the UK also requires additional analysis of local laws and additional measures for transfers of personal data out of the UK to countries (including the U.S.) that have not been deemed by the UK to have adequate data protection laws. In relation to UK-EEA personal data transfers, these can freely continue provided that on the one hand the UK has deemed that the EEA has adequate data protection laws (i.e. we can freely transfer personal data from the U.K. to our business in Belgium or elsewhere in the EEA) and on the other hand the European Commission adopted on 28 June 2021 an adequacy decision for the UK, renewed on December 19, 2025. Contrary to its predecessor, the amended adequacy decision is a full adequacy finding. This means that organizations in the EEA can send personal data to the UK under the EU GDPR without additional safeguards. The amended adequacy decision does however have a limited duration of six years, so that we need to re-evaluate our transfers from the EEA to the UK in 2031 (or earlier if the European Commission intervenes following a lowering of the level of data protection in the UK). We are required to comply with both the GDPR and the UK GDPR, with each regime having the ability to fine up to the greater of €20 million (in the case of the GDPR) or £17,5 million (in the case of the UK GDPR) and 4% of total annual revenue. We may need to appoint a local representative in the UK, and incur other additional costs and risks, as a result of the UK and the EU having separate data protection regimes.

In addition, in the conduct of our business, we may at times process personal data, including health-related personal data. When conducting clinical trials, we face risks associated with collecting trial participants' data, especially health data, in a manner consistent with applicable laws and regulations. In the EU and the UK, certain guidance issued by the organization representing the national data protection supervisory authorities may conflict with the requirements or guidelines of the entities that oversee clinical trials, creating uncertainty, increased compliance costs and potential delays in the process of gaining approval to conduct our clinical trials. Recent guidance from the CJEU may have significantly softened part of our data protection burden in the context of clinical trial activities, however. In a September 4, 2025 judgement (*EDPS v Single Resolution Board*) the CJEU narrowed the circumstances in which pseudonymized data is considered "personal data" under the GDPR. The Court confirmed that pseudonymized data is not automatically "personal data" under the GDPR. Its qualification depends on whether the recipient (the Company, when we use pseudonymized data sets for medical trial activities for instance) of such data can reasonably – taking into account reasonable technical, organization and legal means – reidentify individuals.

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We also face risks inherent in handling and in protecting the security of personal data, including health- related data. In addition to specific healthcare laws and regulations, the U.S. federal government and various states have adopted or proposed laws, regulations, guidelines, and rules with respect to the collection, distribution, use, and storage of personal information of patients. For example, HIPAA imposes requirements on certain healthcare providers, health plans and healthcare clearinghouses, or Covered Entities, as well as their business associates that perform services for them that involve the use or disclosure of individually identifiable health information, called Protected Health Information, or PHI, under HIPAA, relating to the privacy and security of PHI, including the use of mandatory contractual terms, or Business Association Agreements, in some circumstances, as well as privacy and security standards and breach notification requirements. Failure to comply with the HIPAA privacy and security standards can result in significant civil monetary penalties and, in certain circumstances, criminal penalties. HIPAA also imposes penalties on third parties that wrongfully obtain PHI. State attorneys general can also bring a civil action to enjoin a HIPAA violation or to obtain statutory damages on behalf of residents of his or her state.

In addition, state privacy and security laws and regulations vary from state to state, constantly evolve, and remain subject to significant change. In some cases, such laws and regulations can impose more restrictive requirements than HIPAA and other U.S. federal laws, thus complicating compliance efforts. By way of example, California and Virginia have enacted significant privacy laws that give residents of those states expanded rights to access and delete their personal information, opt out of certain personal information sharing, and receive detailed information about how their personal information is used. In addition, new state privacy laws became effective in Florida, Montana and Texas in 2024 and Tennessee and Iowa in 2025 and will become effective in Indiana in 2026, and numerous other states are considering new privacy laws. Furthermore, other U.S. states, such as New York, Massachusetts, and Utah, have enacted stringent data security laws and numerous other states have proposed similar privacy laws. Failure to comply with these state privacy laws could result in penalties and present unresolved compliance issues. In addition, the enactment of a U.S. federal privacy law is possible. The changing number of U.S. state or federal privacy laws may increase our compliance costs and potential liability. New privacy and data security laws have been proposed in more than half of the states in the United States and in the U.S. Congress, reflecting a trend toward more stringent privacy legislation in the United States, which trend may accelerate with increasing concerns about individual privacy. The existence of comprehensive privacy laws in different states in the country will make our compliance obligations more complex and costly and may require us to modify our data processing practices and policies and to incur substantial costs and potential liability in an effort to comply with such legislation. In addition to fines and penalties that may be imposed for failure to comply with state law, some states also provide for private rights of action to patients for misuse of or unauthorized access to personal information.

We are not subject to HIPAA, but our customers, research collaborators and others in the United States with whom we do business are. Accordingly, we must ensure that any business arrangements that we have with Covered Entities are structured to comply with HIPAA and ensure that we have the authority to obtain any PHI that may be disclosed to us. Some countries also are considering or have enacted legislation requiring local storage and processing of data that could increase the cost and complexity of delivering our services. Any actual or perceived failure by us or the third parties with whom we work to comply with privacy or security laws, policies, legal obligations, or industry standards, or any security incident that results in the unauthorized release or transfer of PHI, may result in governmental enforcement actions and investigations by U.S. federal and state regulatory authorities, fines and penalties, claims, litigation, and/or adverse publicity, including by consumer advocacy groups and other private parties, and could cause our customers, their patients and other healthcare professionals to lose trust in us, which could harm our reputation and have a material adverse effect on our business, financial condition, and results of operations.

In addition, many jurisdictions outside of Europe are also considering and/or enacting comprehensive data protection legislation. For example, as of August 2020, the Brazilian General Data Protection Law imposes stringent requirements similar to GDPR with respect to personal information collected from individuals in Brazil.

In China, there have also been recent significant developments concerning privacy and data security. The Data Security Law of the People's Republic of China, or Data Security Law, which took effect on September 1, 2021, requires data processing (which includes the collection, storage, use, processing, transmission, provision and publication of data), to be conducted in a legitimate and proper manner. The Data Security Law imposes data security and privacy obligations on entities and individuals carrying out data processing activities and also introduces a data classification and hierarchical protection system based on the importance of data in economic and social development and the degree of harm it may cause to national security, public interests, or legitimate rights and interests of individuals or organizations if such data are tampered with, destroyed, leaked, illegally acquired or illegally used. The appropriate level of protection measures is required to be taken for each respective category of data.

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Also in China, the Personal Information Protection Law, which took effect on November 1, 2021, introduced stringent protection requirements for processing personal information, which are in many ways akin to the requirements of the GDPR. We may be required to make further significant adjustments to our business practices to comply with the personal information protection laws and regulations in China including the Personal Information Protection Law.

We also continue to see jurisdictions imposing data localization laws. These regulations may interfere with our intended business activities, inhibit our ability to expand into those markets or prohibit us from continuing to offer services in those markets without significant additional costs.

Any failure, or perceived failure, by us to comply with privacy and data protection laws, rules and regulations could result in proceedings or actions against us by governmental entities or others. These proceedings or actions may subject us to significant penalties and negative publicity, require us to change our business practices, increase our costs and severely disrupt our business.

#### Security breaches and other disruptions could compromise our information and expose us to liability, which would cause our business and reputation to suffer.
We and certain third parties that we rely on for our operations collect and store confidential and sensitive information, and our and their operations are highly dependent on information technology systems, including internet-based systems, which may be vulnerable to damage or interruption from earthquakes and hurricanes, fires, floods and other natural disasters, and attacks by computer viruses, unauthorized access, terrorism, and war, as well as telecommunication and electrical failures. Damage or extended periods of interruption to our corporate, development or research facilities due to fire, natural disaster, power loss, communications failure, unauthorized entry or other events could also cause us to cease or delay our manufacturing of the Genio systems. If such an event were to occur and cause interruptions in our operations, it could have a material adverse effect on our business. For example, the loss of clinical trial data from completed, ongoing or planned trials could result in delays in our regulatory approval efforts and significantly increase our costs to recover or reproduce the data. Since the Genio system is a wireless medical device, additional complications may arise with respect to the wireless, RF, technology used for the communication between the system parts. While we have reviewed and determined the integrity of the Genio system and the communication protocol, use of wireless technology imposes a risk that third parties might attempt to access our system. An additional risk is related to interruption or distortion of communication by other devices that might be used in the vicinity of the system, especially when in use by the user, which might have an effect on the effectiveness of the therapy delivered by the system. Any disruption or security breach or other security incident that resulted in a loss of or damage to our data or applications, or the inappropriate access to or disclosure of personal, confidential, or proprietary information could delay our product development, clinical trials, or commercialization efforts, result in increased overhead costs and damage our reputation, all of which could negatively affect our business, financial condition and operating results.

The secure processing, maintenance and transmission of our confidential business information and other information maintained or processed in our business, including sensitive or confidential patient or employee data, is critical to our operations. Such information includes, among other things, intellectual property and proprietary information, the confidential information of any of our future collaborators and licensees, the personal data of our employees, and personal data from patients using the Genio system, which falls into the specially protected category of health data, for which additional safeguards are required under applicable laws. Unauthorized access to or disclosure of any sensitive or confidential patient, trial participant, or employee data, including whether through breach of computer systems, systems failure, employee negligence, fraud or misappropriation, or otherwise, or unauthorized access to or through our information systems and networks, whether by our employees or third parties, or the perception that this has occurred, could result in negative publicity, legal liability and damage to our reputation and could also expose us to sanctions for violations of laws and regulations relating to privacy and data security. Although we have general liability and cybersecurity insurance coverage, our insurance may not cover all claims, continue to be available to us on reasonable terms or be sufficient in amount to cover one or more large claims; additionally, the insurer may disclaim coverage as to any claim. The successful assertion of one or more large claims against us that exceed or are not covered by our insurance coverage or changes in our insurance policies, including premium increases or the imposition of large deductible or co- insurance requirements, could have a material adverse effect on our business, prospects, operating results and financial condition.

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Despite our security measures, our information technology systems and infrastructure may be vulnerable to attacks by hackers or internal bad actors, or breached due to employee error, a technical vulnerability, malfeasance or other disruptions. Phishing attempts, social engineering, and other attacks upon our information technology systems are increasing in their frequency, levels of persistence, sophistication and intensity, and are being conducted by sophisticated and organized groups and individuals with a wide range of motives and expertise. In addition to unauthorized access to or acquisition of personal information, confidential information, or other sensitive information, such attacks could include the deployment of harmful malware and ransomware, and may use a variety of methods, including denial-of-service attacks, social engineering and other means, to attain such unauthorized access or acquisition or otherwise affect service reliability and threaten the confidentiality, integrity and availability of information. Because the techniques used to obtain unauthorized access, disable or degrade service, or sabotage systems change frequently and often are not foreseeable or recognized until launched against a target, we may be unable to anticipate these techniques or to implement adequate preventative measures. Any such access, disclosure, or other loss of information could result in legal claims or proceedings, liability under laws that protect the privacy of personal information, significant regulatory penalties, and such an event could disrupt our operations, damage our reputation, and cause a loss of confidence in us and our ability to commercialize our products and conduct clinical trials, which could adversely affect our reputation and delay our commercialization strategy for our Genio system and clinical development of our current and future products.

***We rely significantly on information technology and any failure, inadequacy, interruption or security lapse of that technology or loss of data, including any cyber security incidents, could compromise sensitive information related to our business, prevent us from accessing critical information or expose us to liability which could harm our ability to operate our business effectively and adversely affect our business and reputation.***

Our ability to execute our business plan and maintain operations depends on the continued and uninterrupted performance of our information technology, or IT, systems, some of which are in our control and some of which are in the control of third parties. In the ordinary course of our business, we collect and store sensitive data, including personally identifiable information about our employees, intellectual property, and proprietary business information (confidential information). We manage and maintain our applications and data utilizing on-site systems and we also have outsourced elements of our operations to third parties, and as a result we manage a number of third-party vendors who may or could have access to our confidential information. These applications and data encompass a wide variety of business-critical information including research and development information and business and financial information.

The secure processing, storage, maintenance and transmission of this critical information is vital to our operations and business strategy. Despite the implementation of security measures, including, whenever possible, the imposition of confidentiality and non-disclosure covenants onto our vendors, our IT systems are vulnerable to risks and damages from a variety of sources, including telecommunications or network failures, cyber-attacks, computer viruses, ransomware attacks, phishing schemes, breaches, unauthorized access, interruptions due to employee error or malfeasance or other disruptions, damage from natural disasters, terrorism, war and telecommunication and electrical failures, or other attempts to harm or access our systems. Moreover, despite network security and back-up measures, some of our servers and those of our business partners are potentially vulnerable to physical or electronic break-ins, including cyber-attacks, computer viruses and similar disruptive problems. These events could lead to the unauthorized access, disclosure and use of confidential information. Breaches resulting in the compromise, disruption, degradation, manipulation, loss, theft, destruction, or unauthorized disclosure or use of confidential information, or the unauthorized access to, disruption of, or interference with our products and services, can occur in a variety of ways, including but not limited to, negligent or wrongful conduct by employees or others with permitted access to our IT systems and information, or wrongful conduct by hackers, competitors, or certain governments. Our third party vendors and business partners face similar risks.

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Cyber-attacks come in many forms, including the deployment of harmful malware or ransomware, exploitation of vulnerabilities, phishing and other use of social engineering, and other means to compromise the confidentiality, integrity, and availability of our IT systems and confidential information. The techniques used by criminal elements to attack computer systems are sophisticated, change frequently and may originate from less regulated or remote areas of the world. As a result, we may not be able to address these techniques proactively or implement adequate preventative measures. There can be no assurance that we will promptly detect or intercept any such disruption or security breach, if at all. If our computer systems are compromised, we could be subject to fines, damages, reputational harm, litigation and enforcement actions, and we could lose trade secrets, the occurrence of which could harm our business, in addition to possibly requiring substantial expenditures of resources to remedy. For example, any such event that leads to unauthorized access, use or disclosure of personal information, including personal information regarding our patients or employees, could harm our reputation, require us to comply with breach notification laws under GDPR and other legal equivalents, and otherwise subject us to liability under laws and regulations that protect the privacy and security of personal information. In addition, the loss of data from clinical trials of the Genio system could result in delays in our regulatory approval efforts and significantly increase our costs to recover or reproduce data, and a cybersecurity breach could adversely affect our reputation and could result in other negative consequences, including disruption of our internal operations, increased cyber security protection costs, lost revenues or litigation. Despite precautionary measures to prevent unanticipated problems that could affect our IT systems, sustained or repeated system failures that interrupt our ability to generate and maintain data could adversely affect our ability to operate our business.

The costs related to significant security breaches or disruptions could be material and could exceed the limits of the cybersecurity insurance we maintain, if any, against such risks. If the information technology systems of our third-party vendors and other contractors and consultants become subject to disruptions or security breaches, we may have insufficient recourse against such third parties and may have to expend significant resources to mitigate the impact of such an event, and to develop and implement protections to prevent future events of this nature from occurring.

We cannot assure you that our data protection efforts and our investment in IT will prevent significant breakdowns, data leakages, breaches in our systems, or those of our third-party vendors and other contractors and consultants, or other cyber incidents that could have a material adverse effect upon our reputation, business, operations, or financial condition. For example, if such an event were to occur and cause interruptions in our operations, or those of our third-party vendors and other contractors and consultants, it could result in a material disruption of our programs and the development of our services and technologies could be delayed. Furthermore, significant disruptions of our internal information technology systems or those of our third-party vendors and other contractors and consultants, or security breaches could result in the loss, misappropriation, and/or unauthorized access, use, or disclosure of, or the prevention of access to, confidential information (including trade secrets or other intellectual property, proprietary business information, and personal information), which could result in financial, legal, business, and reputational harm to us. For instance, any such event that leads to unauthorized access, use, or disclosure of personal information, including personal information regarding our customers or employees, could harm our reputation directly, compel us to comply with federal and/or state breach notification laws and foreign law equivalents, subject us to mandatory corrective action, and otherwise subject us to liability under laws and regulations that protect the privacy and security of personal information, which could result in significant legal and financial exposure and reputational damages that could potentially have an adverse effect on our business.

Although we take measures to protect sensitive data from unauthorized access, use or disclosure, our information technology and infrastructure may be vulnerable to attacks by hackers or viruses or breached due to personnel error, malfeasance, or other malicious or inadvertent disruptions. Any such breach or interruption could compromise our networks and the information stored there could be accessed by unauthorized parties, manipulated, publicly disclosed, lost, or stolen.

Any such access, breach, or other loss of information could result in legal claims or proceedings, liability under domestic or foreign privacy, data protection and data security laws such as GDPR, HIPAA and the Health Information Technology for Economic and Clinical Health Act, or HITECH, and penalties. Notice of certain security breaches must be made to affected individuals, relevant EU supervisory authority, the Secretary of Department of Health and Human Services, or HHS, and for extensive breaches, notice may need to be made to the media or state attorneys general. Such notice could harm our reputation and our ability to compete. Although we have implemented security measures, such data is currently accessible through multiple channels, and there is no guarantee we can protect our data from breach. Unauthorized access, loss or dissemination could also damage our reputation or disrupt our operations, including our ability to conduct our analyses, conduct research and development activities, collect, process and prepare company financial information, and manage the administrative aspects of our business.

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Penalties for violations of these laws vary. For instance, penalties for failure to comply with a requirement of HIPAA and HITECH vary significantly, and include significant civil monetary penalties and, in certain circumstances, criminal penalties with fines up to $250,000 per violation and/or imprisonment. A person who knowingly obtains or discloses individually identifiable health information in violation of HIPAA may face a criminal penalty of up to $50,000 and up to one-year imprisonment. The criminal penalties increase if the wrongful conduct involves false pretenses or the intent to sell, transfer or use identifiable health information for commercial advantage, personal gain or malicious harm. Fines applicable under the GDPR are outlined above.

Further, various states, such as California and Massachusetts, have implemented similar privacy laws and regulations, such as the California Confidentiality of Medical Information Act, that impose restrictive requirements regulating the use and disclosure of health information and other personally identifiable information. These laws and regulations are not necessarily preempted by HIPAA, particularly if a state afford greater protection to individuals than HIPAA. Where state laws are more protective, we have to comply with the stricter provisions. In addition to fines and penalties imposed upon violators, some of these state laws also afford private rights of action to individuals who believe their personal information has been misused. California's patient privacy laws, for example, provide for penalties of up to $250,000 and permit injured parties to sue for damages. Similarly, the California Consumer Privacy Act, or CCPA, allows consumers a private right of action when certain personal information is subject to unauthorized access and exfiltration, theft or disclosure due to a business' failure to implement and maintain reasonable security procedures. The interplay of federal and state laws may be subject to varying interpretations by courts and government agencies, creating complex compliance issues for us and data we receive, use and share, potentially exposing us to additional expense, adverse publicity and liability. Further, as regulatory focus on privacy issues continues to increase and laws and regulations concerning the protection of personal information expand and become more complex, these potential risks to our business could intensify. Changes in laws or regulations associated with the enhanced protection of certain types of sensitive data, for the treatment of genetic data, along with increased customer demands for enhanced data security infrastructure, could greatly increase our cost of providing our products, decrease demand for our products, reduce our revenues and/or subject us to additional liabilities.

***Artificial intelligence presents risks and challenges that can impact our business including by posing security risks to our confidential information, proprietary information, and personal data.***

Issues in the development and use of artificial intelligence, combined with an uncertain regulatory environment, may result in reputational harm, liability, or other adverse consequences to our business operations. As with many technological innovations, artificial intelligence presents risks and challenges that could impact our business. We may adopt and integrate certain general artificial intelligence tools for specific use cases reviewed by legal and information security Our vendors may incorporate generative artificial intelligence tools into their offerings without disclosing this use to us, and the providers of these generative artificial intelligence tools may not meet existing or rapidly evolving regulatory or industry standards with respect to privacy and data protection and may inhibit our or our vendors' ability to maintain an adequate level of service and experience. If we, our vendors, or our third-party partners experience an actual or perceived breach or privacy or security incident because of the use of generative artificial intelligence, we may lose valuable intellectual property and confidential information and our reputation and the public perception of the effectiveness of our security measures could be harmed. Further, bad actors around the world use increasingly sophisticated methods, including the use of artificial intelligence, to engage in illegal activities involving the theft and misuse of personal information, confidential information, and intellectual property. Any of these outcomes could damage our reputation, result in the loss of valuable property and information, and adversely impact our business.

***Changes in or inadequate funding for, or disruptions caused by global health concerns impacting, the FDA, the SEC and other government agencies could hinder their ability to hire and retain key leadership and other personnel, prevent new products from being developed or commercialized in a timely manner or otherwise prevent those agencies from performing normal business functions on which the operation of our business may rely, which could negatively impact our business.***

The ability of the FDA to review and approve new products can be affected by a variety of factors, including government budget and funding levels, ability to hire and retain key personnel and accept the payment of user fees, and statutory, regulatory, and policy changes and other events that may otherwise affect the FDA's ability to perform routine functions. Average review times at the FDA have fluctuated in recent years as a result. In addition, government funding of the SEC and other government agencies on which our operations may rely, including those that fund research and development activities is subject to the political process, which is inherently fluid and unpredictable.

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Future legislative and regulatory proposals may materially impact the ability of the FDA and other regulatory agencies to operate as they have historically operated. We cannot be sure whether additional legislative changes or executive orders will be enacted, or whether any of the FDA's regulations, guidances or interpretations will be changed, or what the impact of such changes on the agency and its scientific review staff, if any, may be. For example, the FDA has experienced significant and rapid fluctuations in leadership and scientific review personnel, which may be key contributing factors in multiple reported delays in agency decision making on marketing applications and agency requests for additional data that are inconsistent with prior regulatory feedback. In addition, the next FDA user fee reauthorization package entered the stakeholder negotiation phase in mid-2025, and any agreement will be sent to Congress in early 2027 for purposes of initiating the legislative process. Reauthorization of the medical device user fee program would need to be finalized by Congress by the end of September 2027 in order to avoid a disruption in FDA's performance goals for activities supported by user fees assessed against industry.

In addition, disruptions at the FDA and other agencies may also slow the time necessary for new medical devices to be reviewed and/or authorized by necessary government agencies, which would adversely affect our business. For example, in recent years, political disputes in Congress may result in a shutdown of the U.S. government, and in such cases certain regulatory agencies, such as the FDA and the SEC, have had to furlough employees and stop critical activities. Moreover, government shutdowns or slowdowns can increase the time needed for an agency to complete its review or make final approvals or other administrative decisions.

If a prolonged government shutdown or slowdown occurs or if global health concerns prevent the FDA or other regulatory authorities or bodies from conducting business as usual or conducting inspections or other regulatory activities, it could significantly impact the ability of the FDA to timely review and process our regulatory submissions, which could have a material adverse effect on our business. Further, future government shutdowns could impact our ability to access the public markets and obtain necessary capital in order to properly capitalize and continue our operations.

#### Risks Related to Intellectual Property

#### The inability to fully protect and exploit our intellectual property and trade secrets may adversely affect our financial performance and prospects.
Our success will depend significantly on our ability to protect our proprietary and licensed in rights, including in particular the intellectual property and trade secrets related to the Genio system. We rely on a combination of patent(s) (applications), trademarks, designs and trade secrets, and use non-disclosure, confidentiality and other contractual agreements to protect our technology. If we are unable to obtain and maintain sufficient intellectual property protection for the Genio system or other product candidates that we may identify, or if the scope of the intellectual property protection obtained is not sufficiently broad, our competitors and other third parties could develop and commercialize product candidates similar or identical to ours, and our ability to successfully commercialize the Genio system and other product candidates that we may pursue may be impaired.

We generally seek patent protection where possible for those aspects of our technology and products that we believe provide significant competitive advantages. However, obtaining, maintaining, defending and enforcing patents is costly, time consuming and complex, and we may not be able to file and prosecute all necessary or desirable patent applications, or maintain, enforce and license any patents that may issue from such patent applications, at a reasonable cost or in a timely manner. It is also possible that we will fail to identify patentable aspects of our research and development output before it is too late to obtain patent protection. Under certain of our license or collaboration agreements, we may not have the right to control the preparation, filing, prosecution and maintenance of patent applications, or to maintain the rights to patents licensed to or from third parties. Further, we cannot be certain that patents will be issued with respect to our pending or future patent applications. In addition, we do not know whether any issued patents will be upheld as valid or proven enforceable against alleged infringers or whether they will prevent the development of competitive patents or provide meaningful protection against competitors or against competitive technologies.

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The patent position of medical device companies generally is uncertain, involves complex legal, technological and factual questions. In addition, the laws of foreign countries may not protect our rights to the same extent as the laws of the United States, or vice versa. As a result, the issuance, scope, validity, enforceability, and commercial value of our patent rights are highly uncertain. The subject matter claimed in a patent application can be significantly reduced before the patent is issued, and its scope can be reinterpreted after issuance. Therefore, our pending and future patent applications may not result in patents being issued in relevant jurisdictions that protect the Genio system or our product candidates, in whole or in part, or which effectively prevent others from commercializing competitive product candidates, and even if our patent applications issue as patents in relevant jurisdictions, they may not issue in a form that will provide us with any meaningful protection for our product candidates or technology, prevent competitors from competing with us or otherwise provide us with any competitive advantage. Additionally, our competitors may be able to circumvent our patents by developing similar or alternative product candidates or technologies in a non-infringing manner.

The issuance of a patent is not conclusive as to its inventorship, scope, validity or enforceability, and our patents may be challenged in the courts or patent offices in the United States and abroad. We may be subject to a third-party preissuance submission of prior art to the United States Patent and Trademark Office, or the USPTO, or become involved in opposition, derivation, revocation, reexamination, inter partes review, post-grant review or interference proceedings challenging our patent rights or the patent rights of others, or other proceedings in the USPTO or applicable foreign offices that challenge priority of invention or other features of patentability. An adverse determination in any such submission, proceeding or litigation could result in loss of exclusivity or freedom to operate, patent claims being narrowed, invalidated or held unenforceable, in whole or in part, limit the scope or duration of the patent protection of the Genio system or our product candidates, all of which could limit our ability to stop others from using or commercializing similar or identical product candidates or technology to compete directly with us, without payment to us, or result in our inability to manufacture or commercialize product candidates or approved products (if any) without infringing third-party patent rights. In addition, if the breadth or strength of protection provided by our patents and patent applications is threatened, regardless of the outcome, it could dissuade companies from collaborating with us to license, develop or commercialize current or future product candidates, or could have a material adverse effect on our ability to raise funds necessary to continue our research programs or clinical trials. Such proceedings also may result in substantial cost and require significant time from our scientists and management, even if the eventual outcome is favorable to us.

In addition, our intellectual property rights might be challenged, invalidated, circumvented or rendered unenforceable. Our competitors or other third parties may successfully challenge and invalidate or render unenforceable our issued patents, including any patents that may be issued in the future. This could prevent or limit our ability to stop competitors from marketing products that are identical or substantially equivalent to the Genio system. In addition, despite the broad definition of our concepts and inventions in our portfolio, as is common in technological progress, competitors may be able to design around our patents or develop products that provide outcomes that are comparable to the Genio system but that are not covered by our patents. Much of our value is in our intellectual property, and any challenge to our intellectual property portfolio (whether successful or not) may affect our value.

#### We could become subject to intellectual property litigation.
The medical device industry is characterized by rapidly changing products and technologies and there is intense competition to establish intellectual property and proprietary rights covering the use of these new products and the related technologies. This vigorous pursuit of intellectual property and proprietary rights has resulted and will continue to result in extensive litigation and administrative proceedings over patent and other intellectual property rights. Whether a product and/or a process infringes a patent involves complex legal and factual issues, and the outcome of such disputes is often uncertain.

There may be existing patents of which we are unaware that are inadvertently infringed by the Genio system. We cannot guarantee that any of our patent searches or analyses, including the identification of relevant patents, the scope of patent claims or the expiration of relevant patents, are complete or thorough, nor can we be certain that we have identified each and every third-party patent and pending patent application in the United States and abroad that is relevant to or necessary for the commercialization of our product candidates in any jurisdiction. Patent applications in the United States and elsewhere are published approximately 18 months after the earliest filing for which priority is claimed, with such earliest filing date being commonly referred to as the priority date. Therefore, patent applications covering our product candidates could have been filed by third parties without our knowledge. Additionally, pending patent applications that have been published can, subject to certain limitations, be later amended in a manner that could cover our product candidates or the use of our product candidates. The scope of a patent claim is determined by an interpretation of the law, the written disclosure in a patent and the patent's prosecution history. Our interpretation of the relevance or the scope of a patent or a pending application may be incorrect, which may negatively impact our ability to market our product candidates.

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We may incorrectly determine that our product candidates are not covered by a third-party patent or may incorrectly predict whether a third party's pending application will issue with claims of relevant scope. Our determination of the expiration date of any patent in the United States or abroad that we consider relevant may be incorrect, which may negatively impact our ability to develop and market our product candidates. Our failure to identify and correctly interpret relevant patents may negatively impact our ability to develop and market the Genio system and our product candidates.

Any infringement claim against us, even if without merit, may cause us to incur substantial costs, and could place a significant strain on our financial resources and/or divert the time and efforts of management from the conduct of our business. In addition, any intellectual property litigation could force us to do one or more of the following: (i) stop selling the Genio system or using technology that contains the allegedly infringing intellectual property; (ii) forfeit the opportunity to license our patented technology to others or to collect royalty payments based upon successful protection and assertion of our intellectual property rights against others; (iii) pay substantial damages to the party whose intellectual property rights we may be found to be infringing; or (iv) redesign those products that contain or utilize the allegedly infringing intellectual property. As of the date of this Annual Report, there is no intellectual property litigation pending against us.

Additionally, competitors and other third parties may infringe or otherwise violate our issued patents or other intellectual property or the patents or other intellectual property of our licensors. For example, on May 30, 2025, Inspire Medical Systems, Inc. ("Inspire") filed a lawsuit against us, in the United States District Court for the District of Delaware, alleging that the Genio system infringes Inspire's U.S. Patent Nos. 10,898,709, 11,806,526 and 11,850,424 (the "Inspire Asserted Patents"). See section titled "Business—Legal Proceedings" for a more detailed discussion.

In addition, our patents or the patents of our licensors may become involved in inventorship or priority disputes. Our pending patent applications cannot be enforced against third parties practicing the technology claimed in such applications unless and until a patent issues from such applications. To counter infringement or other unauthorized use, we may be required to file infringement claims, which can be expensive and time- consuming. For example, on September 15, 2025, we filed a lawsuit against Inspire, again in the U.S. District Court for the District of Delaware, alleging that the Inspire IV and Inspire V systems infringe U.S. Patent Nos. 8,700,183, 9,415,215, and 9,415,216. Additionally, on December 1, 2025, we filed two actions against Inspire and Inspire Medical Systems Europe GmbH (together "Inspire Europe") in the Unified Patent Court in Munich, Germany, alleging that the Inspire IV system infringes two European patents, EP 2 760 528 B1 and EP 2 760 534 B1, and, on December 18, 2025, we filed petitions for *inter partes* review of the Inspire Asserted Patents, asking the U.S. Patent and Trademark Office to determine that the claims of those patents are unpatentable (*i.e*. invalid). See section titled "Business—Legal Proceedings" for a more detailed discussion.

Our ability to enforce patent rights also depends on our ability to detect infringement. It may be difficult to detect infringers who do not advertise the components or methods that are used in connection with their products and services. Moreover, it may be difficult or impossible to obtain evidence of infringement in a competitor's or potential competitor's product or service. Any claims we assert against perceived infringers could provoke these parties to assert counterclaims against us alleging that we infringe their patents or that our patents are invalid or unenforceable. In a patent infringement proceeding, a court may decide that a patent of ours is invalid or unenforceable, in whole or in part, construe the patent's claims narrowly or refuse to stop the other party from using the technology at issue on the grounds that our patents do not cover the technology. An adverse result in any litigation proceeding could put one or more of our owned or licensed patents at risk of being invalidated, held unenforceable or interpreted narrowly. We may find it impractical or undesirable to enforce our intellectual property against some third parties.

***Patent terms may be inadequate to protect our competitive position with respect to the Genio system and our product candidates for an adequate amount of time.***

Patents have a limited lifespan. In the United States, if all maintenance fees are timely paid, the natural expiration of a patent is generally 20 years from its earliest U.S. non-provisional filing date. Various extensions may be available, but the life of a patent, and the protection it affords, is limited. Even if patents covering our product candidates are obtained, once the patent life has expired for a product candidate, we may be open to competition from competitive devices. Given the amount of time required for the development, testing and regulatory review of new product candidates, patents protecting such product candidates might expire before or shortly after such product candidates are commercialized. As a result, our owned and licensed patent portfolio may not provide us with sufficient rights to exclude others from commercializing product candidates similar or identical to ours for a meaningful amount of time, or at all.

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Depending upon the timing, duration and conditions of any FDA marketing approval of our product candidates, one or more of our owned or licensed U.S. patents may be eligible for limited patent term extension under the Hatch-Waxman Act, and similar legislation in the European Union and certain other countries. The Hatch-Waxman Act permits a patent term extension of up to five years for a patent covering an approved product as compensation for effective patent term lost during product development and the FDA regulatory review process. However, we may not receive an extension if we fail to exercise due diligence during the testing phase or regulatory review process, fail to apply within applicable deadlines, fail to apply prior to expiration of relevant patents or otherwise fail to satisfy applicable requirements. Moreover, the length of the extension could be less than we request. Only one patent per approved product can be extended, the extension cannot extend the total patent term beyond 14 years from approval and only those claims covering the approved drug, a method for using it or a method for manufacturing it may be extended. If we are unable to obtain patent term extension or the term of any such extension is less than we request, the period during which we can enforce our patent rights for the applicable product candidate will be shortened and our competitors may obtain approval to market competing products sooner. As a result, our revenue from applicable products could be reduced. Further, if this occurs, our competitors may take advantage of our investment in development and trials by referencing our clinical and nonclinical data and launch their product earlier than might otherwise be the case, and our competitive position, business, financial condition, results of operations and prospects could be materially harmed.

#### If we are unable to protect the confidentiality of our proprietary information, our business and competitive position would be harmed.
We rely upon unpatented confidential and proprietary information, including technical information, know- how, and other trade secrets to develop and maintain our competitive position with respect to the Genio system. While we generally enter into non-disclosure or confidentiality agreements with our employees and other third parties to protect our intellectual property and trade secrets, we cannot guarantee that we have entered into such agreements with each party that may have or has had access to our proprietary information. Further, despite these efforts, any of these parties may breach the agreements and disclose our proprietary information, and we may not be able to obtain adequate remedies for such breaches. Unauthorized parties may also attempt to copy or reverse engineer certain aspects of our product candidates that we consider proprietary. Monitoring unauthorized uses and disclosures is difficult, and we do not know whether the steps we have taken to protect our proprietary information will be effective. If any of our proprietary information is disclosed to or independently developed by a competitor or other third party, our competitive position would be materially and adversely harmed.

#### We depend on exclusive licenses and agreements with third parties, which might not provide adequate protection for our technology.
We rely on licensing agreements providing us exclusivity in the field of our practice. While we have ensured through multiple robust agreements acquisition of exclusive licenses and freedom to operate for our technology, as with any agreement, under unexpected or unpredictable circumstances, these could be under a risk of being terminated despite companies' efforts and diligence in ensuring integrity of the agreement. Should the agreements be found invalid or licenses revoked and the licensor decide to sue us for infringement of its patents rights, this could expose us to risks of litigation. In addition, any intellectual property litigation could force us to do one or more of the following: (i) stop selling the Genio system or using technology that contains the allegedly infringing intellectual property; (ii) forfeit the opportunity to license our patented technology to others or to collect royalty payments based upon successful protection and assertion of our intellectual property rights against others; (iii) pay substantial damages to the party whose intellectual property rights we may be found to be infringing; or (iv) redesign those products that contain or utilize the allegedly infringing intellectual property. The requirement to obtain licenses to third party intellectual property could also arise in the future. If we need to license in any third-party intellectual property, we could be required to pay lump sums or royalties on our products. In addition, if we are required to obtain licenses to third party intellectual property, we might not be able to obtain such licenses on commercially reasonable terms or at all.

We may be subject to claims by third parties asserting that we or our employees have infringed upon, misappropriated or otherwise violated their intellectual property rights, or claiming ownership of what we regard as our own intellectual property.

Although we try to ensure that our employees, consultants and advisors do not use the proprietary information or know-how of others in their work for us, we may be subject to claims that we or these individuals have used or disclosed intellectual property, including trade secrets or other proprietary information, of any such individual's former employer. We may also be subject to claims that patents and applications we have filed to protect inventions of our employees, consultants and advisors, even those related to one or more of our product candidates, are rightfully owned by their former or concurrent employer. Litigation may be necessary to defend against these claims.

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If we fail in prosecuting or defending any such claims, in addition to paying monetary damages, we may lose valuable intellectual property rights or personnel. Even if we are successful in prosecuting or defending against such claims, litigation could result in substantial costs, delay development of our product candidates and be a distraction to management. Any of the foregoing events would harm our business, financial condition, results of operations and prospects.

***If our trademarks and trade names are not adequately protected, then we may not be able to build name recognition in our markets of interest and our business may be adversely affected.***

Our registered or unregistered trademarks or trade names may be challenged, infringed, circumvented or declared generic or determined to be infringing on other marks. We may not be able to protect our rights to these trademarks and trade names, which we need to build name recognition among potential collaborators or customers in our markets of interest. At times, competitors may adopt trade names or trademarks similar to ours, thereby impeding our ability to build brand identity and possibly leading to market confusion. In addition, there could be potential trade name or trademark infringement claims brought by owners of other trademarks or trademarks that incorporate variations of our registered or unregistered trademarks or trade names. Over the long term, if we are unable to establish name recognition based on our trademarks and trade names, then we may not be able to compete effectively and our business may be adversely affected. We may license our trademarks and trade names to third parties, such as distributors. Though these license agreements may provide guidelines for how our trademarks and trade names may be used, a breach of these agreements or misuse of our trademarks and tradenames by our licensees may jeopardize our rights in or diminish the goodwill associated with our trademarks and trade names. Our efforts to enforce or protect our proprietary rights related to trademarks, trade names, and domain names, or other intellectual property may be ineffective and could result in substantial costs and diversion of resources and could adversely affect our business, financial condition, results of operations and prospects.

#### Intellectual property rights do not necessarily address all potential threats.
The degree of future protection afforded by our intellectual property rights is uncertain because intellectual property rights have limitations and may not adequately protect our business or permit us to maintain our competitive advantage. For example:

● others may be able to make products that are similar to any product candidates we may develop or utilize similar technology but that are not covered by the claims of the patents that we license or may own in the future;

● we, or our current or future licensors might not have been the first to make the inventions covered by the issued patent or pending patent application that we license or may own in the future;

● we, or our current or future licensors might not have been the first to file patent applications covering certain of our or their inventions;

● others may independently develop similar or alternative technologies or duplicate any of our technologies without infringing our owned or licensed intellectual property rights;

● it is possible that our pending owned or licensed patent applications or those that we may own or license in the future will not lead to issued patents;

● issued patents that we hold rights to may be held invalid or unenforceable, including as a result of legal challenges by our competitors;

● our competitors might conduct research and development activities in countries where we do not have patent rights and then use the information learned from such activities to develop competitive products for sale in our major commercial markets;

● we may not develop additional proprietary technologies that are patentable;

● the patents of others may harm our business; and

● we may choose not to file a patent in order to maintain certain trade secrets or know-how, and a third party may subsequently file a patent covering such intellectual property.

Should any of these events occur, they could harm our business, financial condition, results of operations and prospects.

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#### Risks Related to the Ordinary Shares

#### The dual listing of our ordinary shares may adversely affect the liquidity and value of the ordinary shares.
Our ordinary shares trade on both Euronext Brussels and the Nasdaq Global Market. Trading of the ordinary shares in these markets will take place in different currencies (U.S. dollars on the Nasdaq Global Market and € on Euronext Brussels), and at different times (resulting from different time zones, different trading days and different public holidays in the United States and Belgium). The trading prices of our ordinary shares on these two markets may differ due to these and other factors. Any decrease in the price of our ordinary shares on Euronext Brussels could cause a decrease in the trading price of the ordinary shares on the Nasdaq Global Market. Investors could seek to sell or buy our ordinary shares to take advantage of any price differences between the markets through a practice referred to as arbitrage. Any arbitrage activity could create unexpected volatility in both the trading prices on one exchange and the ordinary shares available for trading on the other exchange. However, the dual listing of the ordinary shares may reduce the liquidity of these securities in one or both markets and may adversely affect the development of an active trading market for the ordinary shares in the United States.

***The trading price of our equity securities may be volatile due to factors beyond our control, and holders of our ordinary shares could incur substantial losses.***

The market prices of the ordinary shares may be volatile. The stock market in general and the market for biotechnology companies in particular have experienced extreme volatility that has often been unrelated to the operating performance of particular companies. As a result of this volatility, investors may not be able to sell their ordinary shares or shares at or above the price originally paid for the security. The market price for the ordinary shares may be influenced by many factors, including:

● actual or anticipated fluctuations in our financial condition and operating results;

● the release of new data from our current or future clinical trials;

● actual or anticipated changes in our growth rate relative to our competitors;

● competition from existing products or new products that may emerge;

● announcements by us or our competitors of significant acquisitions, strategic partnerships, joint ventures, collaborations or capital commitments;

● failure to meet or exceed financial estimates and projections of the investment community or that we provide to the public;

● issuance of new or updated research or reports by securities analysts;

● fluctuations in the valuation of companies perceived by investors to be comparable to us;

● currency fluctuations;

● additions or departures of key management or scientific personnel;

● disputes or other developments related to proprietary rights, including patents, litigation matters and our ability to obtain patent protection for our technologies;

● our ability to obtain regulatory approval from the FDA to market future products in the United States;

● changes to coverage policies or reimbursement levels by commercial third-party payors and government payors and any announcements relating to coverage policies or reimbursement levels;

● announcement or expectation of additional debt or equity financing efforts;

● issuances or sales of the ordinary shares by us, our insiders or our other shareholders;

● evolving trade policies such as the imposition of new tariffs or the expansion of tariffs affecting medical devices under the current United States administration; and

● general economic and market conditions, including inflation, higher interest rates and potential recession.

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These and other market and industry factors may cause the market price and demand for the ordinary shares to fluctuate substantially, regardless of our actual operating performance, which may limit or prevent investors from readily selling their shares or ordinary shares and may otherwise negatively affect the liquidity of the trading market for ordinary shares.

***If securities or industry analysts do not publish research or publish inaccurate or unfavorable research about our business, the price of the ordinary shares and their trading volume could decline.***

The trading market for the ordinary shares depends in part on the research and reports that securities or industry analysts publish about us or our business. If no or only limited securities or industry analysts cover our company, the trading price for the ordinary shares could be negatively impacted. If one or more of the analysts who covers us downgrades our equity securities or publishes inaccurate or unfavorable research about our business, the price of ordinary shares would likely decline. If one or more of these analysts ceases coverage of our company or fails to publish reports on us regularly, or downgrades our securities, demand for ordinary shares could decrease, which could cause the price of the ordinary shares or their trading volume to decline.

***Short selling may drive down the market price of our ordinary shares.***

Short selling is the practice of selling shares that the seller does not own but rather has borrowed from a third party with the intention of buying identical shares back at a later date to return to the lender. The short seller hopes to profit from a decline in the value of the shares between the sale of the borrowed shares and the purchase of the replacement shares, as the short seller expects to pay less in that purchase than it received in the sale. As it is in the short seller's interest for the price of the shares to decline, many short sellers publish, or arrange for the publication of, negative opinions and allegations regarding the relevant issuer and its business prospects in order to create negative market momentum and generate profits for themselves after selling the shares short. If we were to become the subject of any unfavorable publicity, whether such allegations are proven to be true or untrue, we could have to expend significant resources to investigate such allegations and/or defend ourselves. While we would strongly defend against any such short seller attacks, we may be constrained in the manner in which we can proceed against the relevant short seller by principles of freedom of speech, applicable state law or issues of commercial confidentiality.

***We intend to retain all available funds and any future earnings and, consequently, your ability to achieve a return on your investment will depend on appreciation in the price of the ordinary shares.***

We have never declared or paid any cash dividends on our shares, and we intend to retain all available funds and any future earnings to fund the development and expansion of our business. Therefore, you are not likely to receive any dividends on your ordinary shares for the foreseeable future and the success of an investment in ordinary shares will depend upon any future appreciation in their value. Consequently, investors may need to sell all or part of their holdings of ordinary shares after price appreciation, which may never occur, as the only way to realize any future gains on their investment. There is no guarantee that the ordinary shares will appreciate in value or even maintain the price at which our investors have purchased them. Investors seeking cash dividends should not purchase the ordinary shares.

In addition, if we choose to pay dividends in the future, exchange rate fluctuations may affect the amount of Euros that we are able to distribute, and the amount in U.S. dollars that our shareholders receive upon the payment of cash dividends or other distributions we declare and pay in euros, if any. Any dividends will generally be subject to Belgian withholding tax. See the section of this Annual Report titled "Material Belgian Income Tax Consequences" for a more detailed description of Belgian taxes on dividends. These factors could harm the value of the ordinary shares.

***Investors should be aware that the rights provided to our shareholders under Belgian corporate law and our articles of association differ in certain respects from the rights that you would typically enjoy as a shareholder of a U.S. company under applicable U.S. federal and state laws.***

We are a Belgian company with limited liability. Our corporate affairs are governed by our articles of association and by the laws governing companies incorporated in Belgium. The rights of shareholders and the responsibilities of members of our board of directors may be different from the rights and obligations of shareholders and boards of directors in companies governed by the laws of U.S. jurisdictions. In the performance of its duties, our board is required by Belgian law to consider the interests of our company, its shareholders, its employees and other stakeholders. It is possible that some of these parties will have interests that are different from, or in addition to, the interests of our shareholders.

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#### If we issue ordinary shares in future financings, shareholders may experience dilution and, as a result, our ordinary share price may decline.
We may from time to time issue additional ordinary shares at a discount from the trading price of our ordinary shares. As a result, our shareholders would experience immediate dilution upon the issuance of any of our ordinary shares at such discount. In addition, as opportunities present themselves, we may enter into financing or similar arrangements in the future, including the issuance of debt securities, preference shares or shares. If we issue ordinary shares or securities convertible into ordinary shares of our share capital, our shareholders would experience additional dilution and, as a result, our ordinary share price may decline.

#### It may be difficult for investors outside Belgium to serve process on, or enforce foreign judgments against, us or our directors and senior management.
We are a Belgian public limited liability company. Half of the members of our board of directors and half of the members of our executive management team are residents of the United States. All or a substantial portion of the assets of such non-resident persons and most of our assets are located outside the United States. As a result, it may not be possible for investors to effect service of process upon such persons or on us or to enforce against them or us a judgment obtained in U.S. courts. Original actions or actions for the enforcement of judgments of U.S. courts relating to the civil liability provisions of the federal or state securities laws of the United States are not directly enforceable in Belgium.

The United States and Belgium do not currently have a multilateral or bilateral treaty providing for reciprocal recognition and enforcement of judgments, other than arbitral awards, in civil and commercial matters. In order for a final judgment for the payment of money rendered by U.S. courts based on civil liability to produce any effect on Belgian soil, it is accordingly required that this judgment be recognized or be declared enforceable by a Belgian court in accordance with Articles 22 to 25 of the 2004 Belgian Code of Private International Law. Recognition or enforcement does not imply a review of the merits of the case and is irrespective of any reciprocity requirement. A U.S. judgment will, however, not be recognized or declared enforceable in Belgium, unless (in addition to compliance with certain technical provisions) the Belgian courts are satisfied of the following:

● the effect of the enforcement judgment is not manifestly incompatible with Belgian public policy;

● the judgment did not violate the rights of the defendant;

● the judgment was not rendered in a matter where the parties transferred rights subject to transfer restrictions with the sole purpose of avoiding the application of the law applicable according to Belgian international private law;

● the judgment is not subject to further recourse under U.S. law;

● the judgment is not incompatible with a judgment rendered in Belgium or with a subsequent judgment rendered abroad that might be recognized in Belgium;

● the claim was not filed outside Belgium after the same claim was filed in Belgium, while the claim filed in Belgium is still pending;

● the Belgian courts did not have exclusive jurisdiction to rule on the matter;

● the U.S. court did not accept its jurisdiction solely on the basis of the presence of the plaintiff or the location of goods not direct linked to the dispute in the United States;

● the judgment did not concern the deposit or validity of intellectual property rights when the deposit or registration of those intellectual property rights was requested, done or should have been done in Belgium pursuant to international treaties;

● the judgment did not relate to the validity, operation, dissolution, or liquidation of a legal entity that has its main seat in Belgium at the time of the petition of the U.S. court;

● if the judgment relates to the opening, progress or closure of insolvency proceedings, it is rendered on the basis of the European Insolvency Regulation (EC Regulation No. 1346/2000 of May 29, 2000) or, if not, that (a) a decision in the principal proceedings is taken by a judge in the state where the most important establishment of the debtor was located or (b) a decision in territorial proceedings was taken by a judge in the state where the debtor had another establishment than its most important establishment;

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● the judgment submitted to the Belgian court is authentic under the laws of the state where the judgment was issued; in case of a default judgment, it can be shown that under locally applicable laws the invitation to appear in court was properly served on the defendant; a document can be produced showing that the judgment is, under the rules of the state where it was issued, enforceable and was properly served on the defendant.

In addition to recognition or enforcement, a judgment by a federal or state court in the United States against us may also serve as evidence in a similar action in a Belgian court if it meets the conditions required for the authenticity of judgments according to the law of the state where it was rendered. The findings of a federal or state court in the United States will not, however, be taken into account to the extent they appear incompatible with Belgian public policy.

Based on the lack of a treaty as described above, U.S. investors may not be able to enforce against us or members of our board of directors or our executive management any judgments obtained in U.S. courts in civil and commercial matters, including judgments under the U.S. federal securities laws.

***We are an "emerging growth company" and as a result of the reduced disclosure and governance requirements applicable to emerging growth companies, the ordinary shares may be less attractive to investors.***

We are an "emerging growth company" as defined in the Jumpstart Our Business Startups Act of 2012. For as long as we continue to be an emerging growth company, we may take advantage of exemptions from various reporting requirements that are applicable to other public companies that are not emerging growth companies, including not being required to comply with the auditor attestation requirements of Section 404 of the Sarbanes-Oxley Act of 2002, or Section 404, exemptions from the requirements of holding a nonbinding advisory vote on executive compensation and shareholder approval of any golden parachute payments not previously approved. As an emerging growth company, we are required to report only two years of financial results and selected financial data compared to three and five years, respectively, for comparable data reported by other public companies. We may take advantage of these exemptions until we are no longer an emerging growth company. We could be an emerging growth company for up to five years, although circumstances could cause us to lose that status earlier, including if the aggregate market value of our ordinary shares held by non-affiliates exceeds $700 million as of the end of our second fiscal quarter before that time, in which case we would no longer be an emerging growth company as of the following December 31st (the last day of our fiscal year). We cannot predict if investors will find the ordinary shares less attractive because we may rely on these exemptions. If some investors find the ordinary shares less attractive as a result, there may be a less active trading market for the ordinary shares and the price of the ordinary shares may be more volatile.

***As a foreign private issuer and as permitted by the listing requirements of Nasdaq, we rely on certain home country corporate governance practices rather than the corporate governance requirements of Nasdaq.***

We qualify as a foreign private issuer and our ordinary shares have been approved for listing on Nasdaq. As a result, in accordance with the listing requirements of Nasdaq, we rely on home country governance requirements and certain exemptions thereunder rather than relying on the corporate governance requirements of Nasdaq. For example, we are exempt from certain rules under the Exchange Act that regulate disclosure obligations and procedural requirements related to the solicitation of proxies, consents or authorizations applicable to a security registered under the Exchange Act, including the U.S. proxy rules under Section 14 of the Exchange Act. In addition, our officers and directors are exempt from the reporting and "short-swing" profit recovery provisions of Section 16 of the Exchange Act and related rules with respect to their purchases and sales of our securities. Moreover, while we currently publish annual and semi-annual reports on our website pursuant to the rules of Euronext Brussels and expect to file such financial reports with the SEC, we will not be required to file periodic reports with the SEC as frequently or as promptly as U.S. public companies. Specifically, we are not required to file quarterly reports on Form 10-Q or current reports on Form 8-K that a domestic company would be required to file under the Exchange Act. Accordingly, there may be less publicly available information concerning our company than there would be if we were not a foreign private issuer.

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In addition, the Listing Rules of the Nasdaq Stock Market require a majority of the directors of a listed U.S. company to be independent, whereas in Belgium, only three directors need to be independent. The Listing Rules of the Nasdaq Stock Market further require that each of the nominating, compensation and audit committees of a listed U.S. company be comprised entirely of independent directors. However, the Belgian Corporate Governance Code recommends only that a majority of the directors on the nomination committee meet the technical requirements for independence under Belgian corporate law. At present, our audit committee is composed of three independent directors out of three members, whereas our nomination and remuneration committees are composed of two independent directors out of three members. Our board of directors has no plan to change the composition of our audit committee and nomination and remuneration committee, and we intend to follow home country practice to the maximum extent possible. Therefore, our shareholders may be afforded less protection than they otherwise would have under corporate governance listing standards applicable to U.S. domestic issuers.

#### We may lose our foreign private issuer status in the future, which could result in significant additional costs and expenses.
As a foreign private issuer, we are not required to comply with all the periodic disclosure and current reporting requirements of the Exchange Act and related rules and regulations. The determination of foreign private issuer status will be made annually on the last business day of our most recently completed second fiscal quarter. Accordingly, we will next make a determination with respect to our foreign private issuer status on June 30, 2026. There is a risk that we will lose our foreign private issuer status in the future.

We would lose our foreign private issuer status if, for instance more than 50% of our ordinary shares are owned by U.S. residents or persons and more than 50% of our assets are located in the United States and we continue to fail to meet additional requirements necessary to maintain our foreign private issuer status. The regulatory and compliance costs to us under U.S. securities laws as a U.S. domestic issuer may be significantly greater than the costs we incur as a foreign private issuer. If we are not a foreign private issuer, we will be required to file periodic reports and registration statements on U.S. domestic issuer forms with the SEC, which are more detailed and extensive in certain respects than the forms available to a foreign private issuer. We would be required under current SEC rules to prepare our financial statements in accordance with U.S. GAAP and modify certain of our policies to comply with corporate governance practices associated with U.S. domestic issuers. Such conversion and modifications would involve additional costs. In addition, we may lose our ability to rely upon exemptions from certain corporate governance requirements on U.S. stock exchanges that are available to foreign private issuers, which could also increase our costs.

#### U.S. Holders may suffer adverse tax consequences if we are characterized as a passive foreign investment company, or PFIC.
In general, a non-U.S. corporation is a PFIC for U.S. federal income tax purposes for any taxable year in which (i) 50% or more of the average value of its assets (generally determined on a quarterly basis) consists of assets that produce, or are held for the production of, passive income, or (ii) 75% or more of its gross income consists of passive income. For purposes of the above calculations, a non-U.S. corporation that owns, directly or indirectly, at least 25% by value of the shares of another corporation is treated as if it held its proportionate share of the assets of the other corporation and received directly its proportionate share of the income of the other corporation. Passive income generally includes dividends, interest, investment gains and certain rents and royalties. Cash is generally a passive asset for these purposes. The value goodwill is generally treated as an active asset if it is associated with business activities that produce active income.

If we are a PFIC for any taxable year during which a U.S. holder (as defined below under "Certain Material U.S. Federal Income Tax Considerations to U.S. holders") holds ordinary shares, we will generally continue to be treated as a PFIC with respect to such U.S. holder in all succeeding years during which the U.S. holder owns the ordinary shares regardless of whether we continue to meet the PFIC test described above, unless the U.S. holder makes a specified election once we cease to be a PFIC. If we are classified as a PFIC for any taxable year during which a U.S. holder holds ordinary shares, the U.S. holder may be subject to adverse tax consequences regardless of whether we continue to qualify as a PFIC, including ineligibility for any preferred tax rates on capital gains or on actual or deemed dividends, interest charges on certain taxes treated as deferred, and additional reporting requirements.

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Based on the current estimates, and expected future composition, of our income and the value of our assets, including goodwill, we do not believe we were a PFIC for the 2025 taxable year and do not expect to be a PFIC for the 2026 taxable year. However, our PFIC status for any taxable year is an annual determination that can be made only after the end of that year and will depend on the composition of our income and assets and the value of our assets from time to time. The determination of whether we are a PFIC is fact-intensive and the applicable law is subject to varying interpretation. There can be no assurance that the United States Internal Revenue Service, or IRS, will agree with our conclusion or that the IRS will not successfully challenge our position including our classification of certain income and assets as non-passive or our valuation of our tangible and intangible assets.

A U.S. holder may in certain circumstances mitigate the adverse tax consequences of the PFIC rules by filing an election to treat the PFIC as a QEF, or, if shares of the PFIC are "marketable stock" for purposes of the PFIC rules, by making a mark-to-market election with respect to the shares of the PFIC. However, we do not currently intend to provide the information necessary for U.S. holders to make a QEF election if we were treated as a PFIC for any taxable year and prospective investors should assume that a QEF election will not be available. Furthermore, if a U.S. holder were to make a mark-to-market election with respect to its ordinary shares, the U.S. holder would be required to include annually in its U.S. federal taxable income (taxable at ordinary income rates) an amount reflecting any year end increase in the value of its ordinary shares. For further discussion of the PFIC rules and the adverse U.S. federal income tax consequences in the event we are classified as a PFIC, see the section titled "Certain Material U.S. Federal Income Tax Considerations to U.S. holders."

The U.S. federal income tax rules relating to PFICs are very complex. Prospective U.S. holders are strongly urged to consult their own tax advisors with respect to the impact of PFIC status on the purchase, ownership and disposition of ordinary shares, the consequences to them of an investment in a PFIC, any elections available with respect to the ordinary shares and the IRS information reporting obligations with respect to the purchase, ownership and disposition of ordinary shares of a PFIC.

***If a U.S. Holder is treated as owning at least 10% of our ordinary shares, such holder may be subject to adverse U.S. federal income tax consequences.***

If a U.S. holder (as defined below under "Certain Material U.S. Federal Income Tax Considerations to U.S. Holders") is treated as owning, directly, indirectly or constructively, at least 10% of the value or voting power of our ordinary shares, such U.S. holder may be treated as a "United States shareholder" with respect to each "controlled foreign corporation" in our group, if any. For taxable years ending on or before December 31, 2025, because our group currently includes at least one U.S. subsidiary, under current law, any of our current non-U.S. subsidiaries and any future newly formed or acquired non-U.S. subsidiaries will be treated as controlled foreign corporations, regardless of whether we are treated as a controlled foreign corporation. However, for taxable years ending after December 31, 2025, the One Big Beautiful Bill Act enacted in July 2025, or OBBBA, modifies various rules regarding determining whether a non-U.S. corporation is a controlled foreign corporation and reduced the likelihood that our non-U.S. subsidiaries could be treated as controlled foreign corporations, if we are not treated as a controlled foreign corporation. A United States shareholder of a controlled foreign corporation may be required to annually report and include in its U.S. taxable income its pro rata share of "Subpart F income," "global intangible low-taxed income" (renamed "net CFC tested income" for taxable years ending after December 31, 2025 pursuant to the OBBBA) and investments in U.S. property by controlled foreign corporations, regardless of whether we make any distributions. An individual that is a United States shareholder with respect to a controlled foreign corporation generally would not be allowed certain tax deductions or foreign tax credits that would be allowed to a United States shareholder that is a U.S. corporation. Failure to comply with controlled foreign corporation reporting obligations may subject a United States shareholder to significant monetary penalties. We cannot provide any assurances that we will furnish to any United States shareholder information that may be necessary to comply with the reporting and tax paying obligations applicable under the controlled foreign corporation rules of the Code. U.S. holders should consult their tax advisors regarding the potential application of these rules to their investment in ordinary shares.

#### Our business may become subject to economic, political, regulatory and other risks associated with international operations.
As a company based in Belgium, our business is subject to risks associated with conducting business internationally. Many of our suppliers and collaborative and clinical trial relationships are located outside the United States. Accordingly, our future results could be harmed by a variety of factors, including:

● economic weakness, including inflation, or political instability in particular non-U.S. economies and markets;

● differing and changing regulatory requirements for drug approvals in non-U.S. countries;

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● differing jurisdictions could present different issues for securing, maintaining or obtaining freedom to operate in such jurisdictions;

● potentially reduced protection for intellectual property rights;

● difficulties in compliance with non-U.S. laws and regulations;

● changes in non-U.S. regulations and customs, tariffs and trade barriers;

● changes in non-U.S. currency exchange rates of the pound sterling, the euro and currency controls;

● changes in a specific country's or region's political or economic environment, including the implications of the United Kingdom's withdrawal from the European Union;

● trade protection measures, import or export licensing requirements or other restrictive actions by U.S. or non-U.S. governments;

● differing reimbursement regimes and price controls in certain non-U.S. markets;

● negative consequences from changes in tax laws;

● compliance with tax, employment, immigration and labor laws for employees living or traveling abroad;

● workforce uncertainty in countries where labor unrest is more common than in the United States;

● difficulties associated with staffing and managing international operations, including differing labor relations;

● production shortages resulting from any events affecting raw material supply or manufacturing capabilities abroad;

● the potential for economic or political instability resulting from the ongoing conflicts between Russian and Ukraine and in the Middle East, including any impacts to energy prices or the supply chain; and

● business interruptions resulting from geo-political actions, including war and terrorism, or natural disasters including earthquakes, typhoons, floods and fires.

***We or the third parties upon which we depend may be adversely affected by general political, unstable market and economic conditions and other events beyond our control and our business continuity and disaster recovery plans may not adequately protect us from a serious disaster.***

We have become increasingly subject to the risks arising from adverse changes in market and economic and political conditions, both domestically and globally, including trends toward protectionism and nationalism, other unfavorable changes in economic conditions as well as disruptions in global credit and financial markets, such as inflation, failures and instability in U.S. and international banking systems, downgrades of the U.S. credit rating, rising interest rates, slower economic growth or a recession, and other events beyond our control, such as natural disasters, pandemics such as the COVID-19 (coronavirus) in recent years, epidemics, political instability, and armed conflicts and wars, including the ongoing conflicts between Russia and Ukraine and in the Middle East.

Increases in inflation could raise our costs for commodities, labor, materials and services and other costs required to grow and operate our business, and failure to secure these on reasonable terms may adversely impact our financial condition. Additionally, increases in inflation, along with the uncertainties surrounding geopolitical developments and global supply chain disruptions, have caused, and may in the future cause, global economic uncertainty and uncertainty about the interest rate environment. A failure to adequately respond to these risks could have a material adverse impact on our financial condition, results of operations or cash flows. In response to high levels of inflation and recession fears, the U.S. Federal Reserve, the European Central Bank, and the Bank of England have raised, and may continue to raise, interest rates and implement fiscal policy interventions. Even if these interventions lower inflation, they may also reduce economic growth rates, create a recession, and have other similar effects.

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The U.S. debt ceiling and budget deficit concerns have increased the possibility of credit-rating downgrades and economic slowdowns, or a recession in the United States. Although U.S. lawmakers have previously passed legislation to raise the federal debt ceiling on multiple occasions, there is a history of ratings agencies lowering or threatening to lower the long-term sovereign credit rating on the United States given such uncertainty. On August 1, 2023, Fitch Ratings downgraded the United States' long-term foreign currency issuer default rating to AA+ from AAA as a result of these repeated debt ceiling and budget deficit concerns. The impact of this or any further downgrades to the U.S. government's sovereign credit rating or its perceived creditworthiness could adversely affect the U.S. and global financial markets and economic conditions.

If the equity and credit markets deteriorate, it may make any necessary equity or debt financing more difficult to secure, more costly or more dilutive. Failure to secure any necessary financing in a timely manner and on favorable terms could harm our growth strategy, financial performance and stock price and could require us to delay or abandon plans with respect to our business, including clinical development plans. Further, recent developments in the banking industry could adversely affect our business. If the financial institutions with which we do business enter receivership or become insolvent in the future, there is no guarantee that the Department of the Treasury, the Federal Reserve and the Federal Deposit Insurance Corporation, or FDIC, will intercede to provide us and other depositors with access to balances in excess of the $250,000 FDIC insurance limit, that we would be able to access our existing cash, cash equivalents and investments, that we would be able to maintain any required letters of credit or other credit support arrangements, or that we would be able to adequately fund our business for a prolonged period of time or at all, any of which could have a material adverse effect on our business, financial condition and results of operations. We cannot predict the impact that the high market volatility and instability of the banking sector more broadly could have on economic activity and our business in particular. In addition, there is a risk that one or more of our current service providers, manufacturers or other third parties with which we conduct business may not survive difficult economic times, including the ongoing conflicts between Russia and Ukraine and in the Middle East, the instability of the banking sector, and the uncertainty associated with current worldwide economic conditions, which could directly affect our ability to attain our operating goals on schedule and on budget.

The short and long-term implications of Russia's invasion of Ukraine are difficult to predict at this time. We continue to monitor any adverse impact that the outbreak of war in Ukraine and the subsequent institution of sanctions against Russia by the United States and several European and Asian countries may have on the global economy in general, on our business and operations and on the businesses and operations of our suppliers and customers. For example, a prolonged conflict may result in challenges associated with timely receipt of customer payments and banking transactions, supply-chain issues, increased inflation, escalating energy prices and constrained availability, and thus increasing costs, of raw materials. We will continue to monitor this fluid situation and develop contingency plans as necessary to address any disruptions to our business operations as they develop. To the extent the war in Ukraine may adversely affect our business as discussed herein, it may also have the effect of heightening many of the other risks described herein. Such risks include, but are not limited to, adverse effects on macroeconomic conditions, including inflation; disruptions to our global technology infrastructure, including through cyber-attack, ransom attack, or cyber-intrusion; adverse changes in international trade policies, including tariffs, and relations; our ability to maintain or increase our product prices; disruptions in global supply chains; our exposure to foreign currency fluctuations; and constraints, volatility, or disruption in the capital markets, any of which could negatively affect our business and financial condition.

Certain of our support and administrative functions are located in Tel Aviv, Israel. Accordingly, political, economic and military conditions in Israel, including the ongoing conflicts in the Middle East, may directly adversely affect our business. Any armed conflicts, terrorist activities, political instability in the region or the interruption or curtailment of trade between Israel and its trading partners could adversely affect our business conditions in general and harm our results of operations. Our commercial insurance does not cover losses that may occur as a result of an event associated with the security situation in the Middle East. Although Israeli legislation requires the Israeli government to cover the reinstatement value of direct damages that are caused by terrorist attacks or acts of war, we cannot assure that this government coverage will be maintained, or if maintained, will be sufficient to fully compensate us if any damages are incurred. Any losses or damages incurred by us could have a material adverse effect on our business.

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Changes in U.S. federal policy that affect the geopolitical landscape could give rise to circumstances outside our control that could have negative impacts on our business operations. For example, during the prior Trump administration, increased tariffs were implemented on goods imported into the United States. On April 2, 2025, a universal 10% tariff on all United States imports was announced, with higher tariffs ranging from 11% to 50% on imports from 57 countries, including a 15% tariff on imports from Belgium and Israel and a 39% tariff on imports from Switzerland, effective August 7, 2025. Tariff rates have since fluctuated as a result of bilateral negotiations and legal challenges, and product-specific tariffs have also been implemented. On February 20, 2026, the U.S. Supreme Court ruled against the Trump administration's use of tariffs under the International Emergency Economic Powers Act, or IEEPA, and U.S. Customs and Border Protection halted collections of IEEPA tariffs on February 24, 2026. However, the decision creates uncertainty related to various aspects of the tariffs previously collected under the IEEPA, including whether, and if so, how, companies may be able to recover any portion of IEEPA tariffs previously paid. Additionally, in response to the U.S. Supreme Court ruling, the Trump administration imposed a new worldwide tariff effective for 150 days from February 24, 2026. These ongoing measures have led to retaliatory tariffs from affected countries and have contributed to increased trade tensions and economic uncertainty. Political tensions as a result of such trade policies could reduce trade volume, investment, technological exchange and other economic activities between major international economies, resulting in a material adverse effect on global economic conditions and the stability of global financial markets. Any changes in political, trade, regulatory, and economic conditions, including U.S. trade policies, could have a material adverse effect on our financial condition or results of operations.

The effects of current and future economic and political conditions and other events beyond our control on us, patients, our third party vendors, including clinical trial sites, and our partners could severely disrupt our operations and have a material adverse effect on our business, results of operations, financial condition and prospects. If a natural disaster, power outage or other event occurred that prevented us from using all or a significant portion of our headquarters, that damaged critical infrastructure, such as the manufacturing facilities of our third-party contract manufacturers, or that otherwise disrupted operations, it may be difficult or, in certain cases, impossible for us to continue our business for a substantial period of time. The disaster recovery and business continuity plans we have in place may prove inadequate in the event of a serious disaster or similar event. We may incur substantial expenses as a result of the limited nature of our disaster recovery and business continuity plans, which could have a material adverse effect on our business.

#### Climate change or legal, regulatory or market measures to address climate change may negatively affect our business, results of operations, cash flows and prospects.
We believe that climate change has the potential to negatively affect our business and results of operations, cash flows and prospects. We are exposed to physical risks (such as extreme weather conditions or rising sea levels), risks in transitioning to a low-carbon economy (such as additional legal or regulatory requirements, changes in technology, market risk and reputational risk) and social and human effects (such as population dislocations and harm to health and well-being) associated with climate change. These risks can be either acute (short-term) or chronic (long-term).

The adverse impacts of climate change include increased frequency and severity of natural disasters and extreme weather events such as hurricanes, tornados, wildfires (exacerbated by drought), flooding, and extreme heat. Extreme weather and sea-level rise may pose physical risks to our facilities as well as those of our suppliers. Such risks may include losses incurred as a result of physical damage to facilities, loss or spoilage of inventory, and business interruption caused by such natural disasters and extreme weather events. Other potential physical impacts due to climate change may include reduced access to high-quality water in certain regions and the loss of biodiversity, which could impact future product development. These risks could potentially disrupt our operations and supply chains, which may result in increased costs.

***New legal or regulatory requirements may be enacted to prevent, mitigate, or adapt to the implications of a changing climate and its effects on the environment. These regulations, which may differ across jurisdictions, could potentially result in us being subject to new or expanded carbon pricing or taxes, increased compliance costs, restrictions on greenhouse gas emissions, investment in new technologies, increased carbon disclosure and transparency, upgrade of facilities to meet new building codes, and the redesign of utility systems, which could increase our operating costs, including the cost of electricity and energy used by us. Our supply chain would likely be subject to these same transitional risks and would likely pass along any increased costs to us.***

***While we believe that the potential risks and impacts of climate change could affect us, we believe that currently these potential risks and impacts are not material to the Company's business and operations.***

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#### We are exposed to changes in foreign currency exchange rates.
We incur some of our expenses, and derive certain of our revenues, in currencies other than the Euro. In particular, as we expand our operations and conduct additional clinical trials in the United States, we will incur additional expenses in U.S. dollars. As a result, we are exposed to foreign currency exchange risk as our results of operations and cash flows are subject to fluctuations in foreign currency exchange rates.

We currently do not engage in hedging transactions to protect against uncertainty in future exchange rates between particular foreign currencies and the Euro. Therefore, an unfavorable change in the value of the Euro against the U.S. dollar could have a negative impact on our revenue and earnings growth. We cannot predict the impact of foreign currency fluctuations, and foreign currency fluctuations in the future may adversely affect our financial condition, results of operations and cash flows. Our ordinary shares in the U.S. trade in U.S. dollars on Nasdaq, while our ordinary shares trade in Euro on Euronext Brussels. Our financial statements are prepared in euro. Therefore, fluctuations in the exchange rate between the Euro and the U.S. dollar will also affect, among other matters, the value of our ordinary shares.

We could also sign contracts denominated in currencies other than the euro, which would increase our exposure to currency risk. In accordance with our business decisions, our exposure to this type of risk could change depending on:

● the currencies in which we receive our revenues;

● the currencies chosen when agreements are signed, such as licensing agreements, or co-marketing or co-development agreements;

● the location of clinical trials; and

● our policy for insurance cover.

At present, we have not put any specific hedging arrangements in place to address these risks. Should any of these risks materialize, this could have a material adverse effect on our business, prospects, financial condition and results of operations.

#### Shareholders outside Belgium may be subject to exchange rate risk.
Our ordinary shares are denominated in euros. Accordingly, an investment in the ordinary shares by an investor whose principal currency is not the Euro may expose such investor to foreign currency exchange rate risk. Any depreciation of the Euro against such foreign currency would reduce the value of the investment in the ordinary shares in terms of such foreign currency.

***We incur significant increased costs as a result of operating as a company that is publicly listed on both Nasdaq in the United States and Euronext Brussels in Belgium, and our management is required to devote substantial time to new compliance initiatives.***

As a company listed on Nasdaq in the U.S., we incur legal, accounting, and other expenses that we would not incur if we were only listed on Euronext Brussels. We are subject to the reporting requirements of the Securities Exchange Act of 1934, or the Exchange Act, the Sarbanes-Oxley Act, the Dodd-Frank Wall Street Reform and Consumer Protection Act, the Nasdaq listing requirements and other applicable securities rules and regulations. Continued compliance with these rules and regulations will increase our legal and financial compliance costs, make some activities more difficult, time consuming or costly and increase demand on our systems and resources, particularly after we are no longer an "emerging growth company" and/or a foreign private issuer. The Exchange Act requires that, as a public company, we file annual, semi-annual and current reports with respect to our business, financial condition and result of operations. However, as a foreign private issuer, we are not required to file quarterly and current reports with respect to our business and results. In 2025, we made annual, semiannual and quarterly reporting with respect to our listing on Euronext Brussels.

Moreover, these rules and regulations will increase our legal and financial compliance costs and will make some activities more time-consuming and costly. For example, we expect that these rules and regulations may make it more difficult and more expensive for us to obtain director and officer liability insurance, which in turn could make it more difficult for us to attract and retain qualified senior management personnel or members for our board of directors.

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However, these rules and regulations are often subject to varying interpretations, in many cases due to their lack of specificity, and, as a result, their application in practice may evolve over time as new guidance is provided by regulatory and governing bodies. This could result in continuing uncertainty regarding compliance matters and higher costs necessitated by ongoing revisions to disclosure and governance practices.

Further, being a company listed in the U.S. and in Belgium with ordinary shares admitted to trading on Euronext Brussels impacts the disclosure of information and requires compliance with two sets of applicable rules. From time to time, this may result in uncertainty regarding compliance matters and result in higher costs necessitated by legal analysis of dual legal regimes, ongoing revisions to disclosure and adherence to heightened governance practices. As a result of the enhanced disclosure requirements of the U.S. securities laws, business and financial information that we report is broadly disseminated and highly visible to investors, which we believe may increase the likelihood of threatened or actual litigation, including by competitors and other third parties, which could, even if unsuccessful, divert financial resources and the attention of our management from our operations.

***As a result of being a company listed in the U.S., we are subject to additional regulatory compliance requirements, including Section 404, and if we fail to maintain an effective system of internal controls, we may not be able to accurately report our financial results or prevent fraud.***

Pursuant to Section 404, our management is required to assess and attest to the effectiveness of our internal control over financial reporting in connection with issuing our consolidated financial statements as of and for the year ending December 31, 2025. See "Item 15. Controls and Procedures." Section 404 also requires an attestation report on the effectiveness of internal control over financial reporting be provided by our independent registered public accounting firm beginning with our annual report following the date on which we are no longer an "emerging growth company", which may be up to five fiscal years from the date of our listing of ordinary shares on Nasdaq.

Complying with Section 404 is costly and challenging, and management's attention may be diverted from other business concerns, which could adversely affect our results. We have hired employees and engaged outside consultants, and may need to continue to hire employees and engage outside consultants, to comply with these requirements, which may further increase expenses. If we fail to comply with the requirements of Section 404, we may be subject to sanctions or investigations by regulatory authorities, including the SEC and Nasdaq. Furthermore, our inability to attest to the effectiveness of our internal control over financial reporting may result in the loss of investor confidence in the accuracy and completeness of our financial reports, and the market price of our ordinary shares may decline. Our failure to implement or maintain effective internal control over financial reporting could also restrict our future access to the capital markets and subject each of us, our directors and our officers to both significant monetary and criminal liability.

In addition, changing laws, regulations and standards relating to corporate governance and public disclosure are creating uncertainty for public companies, increasing legal and financial compliance costs and making some activities more time consuming. These laws, regulations and standards are subject to varying interpretations, in many cases due to their lack of specificity, and, as a result, their application in practice may evolve over time as new guidance is provided by regulatory and governing bodies. This could result in continuing uncertainty regarding compliance matters and higher costs necessitated by ongoing revisions to disclosure and governance practices. We intend to invest resources to comply with evolving laws, regulations and standards, and this investment may result in increased general and administrative expense and a diversion of management's time and attention from revenue generating activities to compliance activities. If our efforts to comply with new laws, regulations and standards differ from the activities intended by regulatory or governing bodies due to ambiguities related to their application and practice, regulatory authorities may initiate legal proceedings against us and our business, financial position, results and prospects may be adversely affected.

***If we fail to implement and maintain effective internal controls over financial reporting, our ability to produce accurate financial statements on a timely basis could be impaired.***

We are subject to reporting obligations under U.S. securities laws and the Sarbanes-Oxley Act of 2002 (the "Sarbanes-Oxley Act"). Section 404 of the Sarbanes-Oxley Act requires that we include a report from management on the effectiveness of our internal control over financial reporting. As a result of our failure to remediate the material weaknesses identified herein, our management has concluded that our internal control over financial reporting was not effective as of December 31, 2025. This conclusion could adversely impact the market price of our ordinary shares due to a loss of investor confidence in the reliability of our reporting processes and the accuracy or completeness of our reported financial information.

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We are required to perform system and process evaluations and testing of our internal controls over financial reporting to allow our management to report on the effectiveness of our internal control over financial reporting. In addition, our compliance with Section 404 of the Sarbanes-Oxley Act will require that we incur substantial accounting expense, spend significant management effort, continue to hire additional accounting and financial staff with the appropriate experience and technical accounting knowledge, and compile the system and process documentation necessary to perform the evaluation needed to comply with Section 404 of the Sarbanes-Oxley Act. We have not been able to complete our testing or may not be able to complete our evaluation, testing and any required remediation in a timely fashion. Any failure to implement required new or improved controls, or difficulties encountered in their implementation and our evaluation of said controls could cause us to fail to meet our reporting obligations. In addition, any testing by us conducted in connection with Section 404 of the Sarbanes-Oxley Act, or any subsequent testing by our independent registered public accounting firm, may reveal additional deficiencies in our internal controls over financial reporting that are deemed to be material weaknesses or that may require prospective or retroactive changes to our financial statements or identify other areas for further attention or improvement. We cannot assure you that there will not be additional material weaknesses in our internal control over financial reporting in the future.

For as long as we are an "emerging growth company" under the JOBS Act, our independent registered public accounting firm is not required to attest to the effectiveness of our internal controls over financial reporting pursuant to Section 404 of the Sarbanes-Oxley Act. We will lose our "emerging growth company" status as of the last day of our current fiscal year. At the time when we are no longer an emerging growth company, we may report that there continue to exist material weaknesses and our independent registered public accounting firm may issue a report that is adverse in the event if the level at which our controls are designed or operating is not satisfactory. Our remediation efforts may not be sufficient for us to avoid a material weakness in the future. Undetected material weaknesses in our internal controls could lead to financial statement restatements and require us to incur remediation costs. Failure to remedy any material weakness in our internal control over financial reporting, or to implement or maintain other effective control systems required of public companies, could also restrict our future access to the capital markets.

***In connection with our preparation and the audit of our consolidated financial statements as of and for the year ended December 31, 2025, we identified material weaknesses in our internal control over financial reporting. Additionally, we may identify additional material weaknesses in the future that may cause us to fail to meet our reporting obligations or result in material misstatements in our financial statements. If we fail to remediate our material weaknesses, we may not be able to report our financial results accurately or prevent fraud.***

As a public company, we are operating in an increasingly demanding regulatory environment that requires us to comply with, among other things, the Sarbanes-Oxley Act and related rules and regulations of the SEC's substantial disclosure requirements, accelerated reporting requirements and complex accounting rules. Company responsibilities required by the Sarbanes-Oxley Act include establishing corporate oversight and adequate internal control over financial reporting and disclosure controls and procedures. Effective internal controls are necessary for us to produce reliable financial reports and are important to help prevent financial fraud.

In connection with our preparation and the audit of our consolidated financial statements as of and for the year ended December 31, 2025, we identified material weaknesses in our internal control over financial reporting. As defined in the standards established by the PCAOB, a "material weakness" is a deficiency, or a combination of deficiencies, in internal control over financial reporting such that there is a reasonable possibility that a material misstatement of our annual or interim financial statements will not be prevented or detected on a timely basis.

The material weaknesses identified during the audit of our consolidated financial statements as of and for the year ended December 31, 2025 relate to:

● Insufficient accounting and supervisory personnel with the appropriate level of technical accounting experience and training, as well as a lack of sufficient personnel to carry out all control activities;

● Insufficient documented evidence of control implementation and execution in certain processes, including US operations, resulting in an inability to validate the design and operating effectiveness of our risk-based control assessment, which leads to insufficient procedures and controls, including IT General Controls, to ensure that accurate financial statements can be prepared and reviewed on a timely basis for annual reporting purposes.

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To address the material weaknesses identified, we have taken, and continue to take, several remedial actions, including the engagement of an external professional advisor that is evaluating and validating the design effectiveness of our internal control framework. Based on the outcomes of such evaluation, we formalized a risk assessment and scoping exercise and designed and implemented an internal control framework to cover risks identified as part of such risk assessment. Accordingly, our remediation plan is underway, however, it had not sufficiently advanced by December 31, 2025 to remediate these material weaknesses.

If we are unable to successfully remediate our identified ongoing material weaknesses, or if we discover additional material weaknesses, we would be required to continue disclosing such material weaknesses in future filings with the SEC, which could adversely impact investor confidence in our company and the market price of our ordinary shares, and could subject us to litigation or regulatory enforcement actions.

#### We may be subject to securities litigation, which is expensive and could divert management's attention.
The market price of the ordinary shares may be volatile and, in the past, companies that have experienced volatility in the market price of their stock have been subject to securities class action litigation. We may be the target of this type of litigation in the future. Securities litigation against us could result in substantial costs and divert our management's attention from other business concerns, which could seriously harm our business.

***We are a Belgian public limited liability company, and shareholders of our company may have different and, in some cases, more limited shareholder rights than shareholders of a U.S. listed corporation.***

We are a Belgian company with limited liability. Our corporate affairs are governed by our articles of association and by the laws governing companies incorporated in Belgium. The rights of shareholders and the responsibilities of members of our board of directors may be different from the rights and obligations of shareholders and boards of directors in companies governed by the laws of U.S. jurisdictions. In the performance of its duties, our board is required by Belgian law to consider the interests of our company, its shareholders, its employees and other stakeholders, in all cases with due observation of the principles of reasonableness and fairness. It is possible that some of these parties will have interests that are different from, or in addition to, the interests of our shareholders.

#### Investors resident in countries other than Belgium may suffer dilution if they are unable to participate in future preferential subscription rights offerings.
Under Belgian law and our constitutional documents, shareholders have a waivable and cancellable preferential subscription right to subscribe *pro rata* to their existing shareholdings to the issuance, against a contribution in cash, of new ordinary shares or other securities entitling the holder thereof to new ordinary shares, unless such rights are limited or cancelled by resolution of our general shareholders' meeting or, if so authorized by a resolution of such meeting, our board of directors. The exercise of preferential subscription rights by certain shareholders not residing in Belgium (including those in the United States, Australia, Israel, Canada or Japan and taking into account the current shareholding and international network of our current board of directors) may be restricted by applicable law, practice or other considerations, and such shareholders may not be entitled to exercise such rights, unless the rights and ordinary shares are registered or qualified for sale under the relevant legislation or regulatory framework. In particular, we may not be able to establish an exemption from registration under the U.S. Securities Act, and we are under no obligation to file a registration statement with respect to any such preferential subscription rights or underlying securities or to endeavor to have a registration statement declared effective under the U.S. Securities Act. Shareholders in jurisdictions outside Belgium who are not able or not permitted to exercise their preferential subscription rights in the event of a future preferential subscription rights, equity or other offering may suffer dilution of their shareholdings.

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#### Takeover provisions in the national law of Belgium may make a takeover difficult.
Public takeover bids on our shares and other voting securities, such as warrants or convertible bonds, if any, are subject to the Belgian Act of April 1, 2007 on public takeover bids, as amended and implemented by the Belgian Royal Decree of April 27, 2007, or Royal Decree, and to the supervision by the Belgian Financial Services and Markets Authority, or FSMA. Public takeover bids must be made for all of our voting securities, as well as for all other securities that entitle the holders thereof to the subscription to, the acquisition of or the conversion into voting securities. Prior to making a bid, a bidder must issue and disseminate a prospectus, which must be approved by the FSMA. The bidder must also obtain approval of the relevant competition authorities, where such approval is legally required for the acquisition of our company. The Belgian Act of April 1, 2007 provides that a mandatory bid will be required to be launched for all of our outstanding shares and securities giving access to ordinary shares if a person, as a result of its own acquisition or the acquisition by persons acting in concert with it or by persons acting on their account, directly or indirectly holds more than 30% of the voting securities in a company that has its registered office in Belgium and of which at least part of the voting securities are traded on a regulated market or on a multilateral trading facility designated by the Royal Decree. The mere fact of exceeding the relevant threshold through the acquisition of one or more shares will give rise to a mandatory bid, irrespective of whether or not the price paid in the relevant transaction exceeds the current market price.

There are several provisions of Belgian company law and certain other provisions of Belgian law, such as the obligation to disclose important shareholdings and merger control, that may apply to us and which may make an unfriendly tender offer, merger, change in management or other change in control, more difficult. These provisions could discourage potential takeover attempts that third parties may consider and thus deprive the shareholders of the opportunity to sell their shares at a premium (which is typically offered in the framework of a takeover bid).

#### Item 4. Information on the Company
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A. **History and Development of the Company** 

We were incorporated on July 15, 2009 as a company with limited liability (naamloze vennootschap/ société anonyme) incorporated and operating under the laws of Belgium. We are registered with the legal entities register (Brabant Wallon) under enterprise number 0817.149.675. We were publicly listed on Euronext Brussels in September 2020 and we were publicly listed on The Nasdaq Global Market in July 2021.

We have four wholly owned subsidiaries: Nyxoah Ltd, an Israeli limited company incorporated in January 2008 under the name M.L.G. Madaf G. Ltd and our subsidiary since October 2009, Nyxoah Pty Ltd, an Australian limited company incorporated in 2017, Nyxoah, Inc., a Delaware corporation incorporated in May 2020, and Nyxoah GmbH, a German limited liability company incorporated in May 2023 under the name Blitz F23-668 GmbH and our subsidiary since July 2023. Our headquarters and principal executive offices are located at Rue Edouard Belin 12, 1435 Mont-Saint-Guibert, Belgium, and our telephone number is +32 10 45 90 75. Our website address is www.nyxoah.com. Our website and the information contained on or accessible through our website are not part of this Annual Report. Our authorized representative in the United States is Nyxoah, Inc. Our agent for service of process in the United States is Corporation Service Company, 1090 Vermont Avenue N.W., Washington D.C. 20005.

We file reports and other information with the SEC. The SEC maintains an internet site that contains reports, proxy and information statements, and other information regarding issuers that file electronically with the SEC (http://www.sec.gov).

#### Capital Expenditures
Our capital expenditures amounted to €3.7 million, €5.9 million and €10.5 million for the years ended December 31, 2025, 2024 and 2023, respectively.

For the year ended December 31, 2025, our principal capital expenditures mainly related to capitalized development expenses, establishment of U.S. production line and purchases of laboratory equipment and investments in the construction of new clean rooms.

For the year ended December 31, 2024, our principal capital expenditures mainly related to capitalized development expenses, establishment of U.S. production line and purchases of laboratory equipment and investments in the construction of new clean rooms.

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For the year ended December 31, 2023, our principal capital expenditures mainly related to capitalized development expenses, establishment of U.S. production line and purchases of laboratory equipment and investments in the construction of new clean rooms.

**B.**Business

#### Overview
We are a medical technology company focused on the development and commercialization of innovative solutions to treat Obstructive Sleep Apnea, or OSA. Our lead solution is the Genio system, a CE-Marked and FDA approved, patient-centric next generation hypoglossal neurostimulation, or HGNS, therapy for the treatment of moderate to severe OSA, implanted via a single-incision procedure. OSA is the world's most common sleep disordered breathing condition and is associated with increased mortality risk and comorbidities including cardiovascular diseases, depression and stroke. Our technology platform is a first-of-its-kind HGNS device designed to treat OSA through bilateral stimulation, by maintaining upper airway patency to reduce obstructive breathing events during sleep. We started generating revenue from the sale of the Genio system in Europe in July 2020. On August 8, 2025, the FDA approved the Genio system for a subset of adult patients with moderate to severe OSA with an Apnea-Hypopnea Index, or AHI, of greater than or equal to 15 and less than or equal to 65, and we started generating revenue from the sale of the Genio system in the U.S. in September 2025. We are building a growing body of clinical evidence to further support the strong value proposition of the Genio system and its ability to improve the health and quality of life of OSA patients.

OSA occurs due to the relaxation of the soft tissue, throat and tongue muscles in a patient's airway, which causes an obstruction that temporarily prevents breathing during sleep. In patients with OSA, the airway repeatedly becomes partially or completely blocked, thereby limiting the airflow reaching the lungs from sufficiently oxygenating the blood. Approximately 425 million people between the ages of 30 and 69 globally suffer from moderate to severe OSA. This chronic disease negatively affects a patient's health and quality of life.

Published scientific literature estimates that there are currently approximately 23.8 million individuals with moderate to severe OSA in our initial target markets in Europe. Based on published scientific literature, we estimate that approximately 2.6 million patients are diagnosed annually in those countries and that approximately 80% of diagnosed patients are prescribed a continuous positive airway pressure, or CPAP, device. Published scientific literature reports non-compliance rates to CPAP between 29% and 83%. Based on these data, and for purposes of calculating the total addressable market in Europe for the Genio system, we estimate that approximately 35% of patients that are prescribed CPAP in those countries are not compliant with the therapy. Additionally, certain patients possess anatomical characteristics, including higher body-mass-index or increased tongue fat deposition that make them ineligible for HGNS. Taking that into account, we estimate that approximately 70% of those non-compliant patients are eligible for HGNS based on their anatomical characteristics. As a result, we believe the total addressable market in Europe for the Genio system is at least 515,000 patients, which represents an estimated annual market opportunity of approximately $10 billion based on our current pricing for the Genio system. In the United States, published scientific literature estimates that there are approximately 23.7 million individuals with moderate to severe OSA. Based on the same assumptions set out above, we estimate a target market of approximately 510,000 patients in the United States, which represents an estimated annual total addressable market of approximately $10 billion based on our current pricing for the Genio system.

The standard of care first-line therapy for patients with moderate to severe OSA is CPAP. CPAP is a treatment whereby air, at a constant or automated pressure, is pushed into the upper airway via a facial or nasal mask that the patient must wear during sleep. Despite its established clinical effectiveness, CPAP has been associated with limitations related to patient adherence. As a result, there is a need for alternative treatment options for patients with moderate to severe OSA who are unable to tolerate or adhere to CPAP therapy. In recent years, neurostimulation technology has emerged as a viable second-line therapy to treat patients suffering from moderate to severe OSA. This technology is centered on stimulating the hypoglossal nerve, which activates the genioglossus muscle resulting in a forward protrusion of the tongue. HGNS therapies have been shown to be a safe and effective treatment for those suffering from moderate to severe OSA.

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Systems competing with our Genio system typically require multiple incisions and implantable components, including an implantable pulse generator with a battery and one or more leads. In addition, these competing systems exclude a subset of OSA patients diagnosed with complete concentric collapse, or CCC, at the level of the soft palate, as such patients are currently contraindicated for these other HGNS therapies. Unlike other HGNS technologies indicated for treating OSA that provide unilateral stimulation of the hypoglossal nerve, our Genio system provides bilateral stimulation. Clinical data generated outside the United States for the Genio system supports the effectiveness of bilateral stimulation in treating patients with CCC. An ongoing clinical study in the United States (ACCCESS) aims to further evaluate the therapy in this patient population. While our Genio system is not contraindicated for CCC in the United States, the Genio surgeon manual includes a warning that safety and effectiveness have not been established in patients with CCC at the soft palate level.

To diagnose CCC, a drug induced sleep endoscopy, or DISE, procedure is required. During this procedure, the patient receives propofol and/or midazolam to artificially induce sleep, and the pharyngeal collapse patterns are visualized using a flexible fiber optic nasopharyngoscope, a soft and flexible endoscope which is inserted in the patient's nose to visualize the pharyngeal area and assess the level, direction and degree of the collapsed area. Currently, the only other HGNS therapy approved in the United States requires all patients seeking HGNS therapy to undergo a DISE procedure. It is estimated that approximately 35% of moderate to severe OSA patients are affected by CCC and are therefore unable to receive currently available neurostimulation treatment in the United States.

Our Genio system includes the first leadless, externally-powered neurostimulator, implanted via a single-incision procedure, capable of delivering bilateral HGNS for patients with moderate to severe OSA who did not tolerate, have failed or refused conventional positive airway pressure, or PAP, therapy. We developed the Genio system with a patient-focused approach, designed with considerations for comfort and safety to support long term use.

The Genio system includes a single implanted device that is placed through an incision under the chin. The power source for the stimulator – the activation chip – is external. The external activation chip eliminates the need for additional surgical procedures related to battery replacement and enables software, firmware or external hardware updates without surgical intervention. Unlike competing HGNS therapies, the lack of an implantable battery or additional leads limits the need for complex tunneling. Patients return to the sleep physician approximately eight weeks after implant for device activation.

We continue to develop clinical evidence on the Genio system. In 2019, we completed our BiLAteral hypoglossal nerve STimulation for treatment of Obstructive Sleep Apnea, or BLAST OSA, trial, a prospective, open label, non-randomized, single arm treatment trial involving 27 implanted participants. Twenty-two patients completed the protocol, and the trial met all primary, secondary and exploratory endpoints. In the six-month data, the mean individual reduction in the AHI events per hour was 47.3%. Participants' AHI decreased from 23.7±12.2 to 12.9±10.1, representing a mean change of 10.8 events per hour. The results of the trial were published in the European Respiratory Journal in October 2019 and served as the basis for CE Mark approval of the Genio system.

In June 2021, we announced initial top-line results based on six-month data from our BilatEral Hypoglossal Nerve StimulaTion for TreatmEnt of ObstRuctive SLEEP Apnoea With and Without Complete Concentric Collapse clinical trial, or the BETTER SLEEP trial. BETTER SLEEP is a multicenter, prospective, open-label trial conducted in Australia and New Zealand to evaluate the effectiveness of the Genio system for patients suffering from CCC. Based on this data, in October 2021, the EU Notified Body expanded the CE Mark indication for the Genio system in Europe to include OSA patients with CCC, eliminating the need for a DISE procedure to assess the presence of CCC. Additionally, in September 2021, the Genio system received Breakthrough Device designation from the U.S. Food and Drug Administration, or FDA, for the treatment of OSA with CCC, supported by initial clinical evidence from the BETTER SLEEP trial.

We obtained authorization in additional target markets and initiated our Dual-sided Hypoglossal neRvE stimulAtion for the treatMent of Obstructive Sleep Apnea clinical trial, or DREAM trial, a multicenter, prospective, open-label, pivotal Investigational Device Exemption, or IDE, trial which was designed to support marketing authorization in the United States. We presented 12-month data on the first 34 DREAM patients reaching 12-month follow-up as a late-breaking abstract at SLEEP 2023, a joint meeting of the American Academy of Sleep Medicine and the Sleep Research Society, demonstrating a 65% AHI responder rate, a 76% ODI responder rate and safety in line with expectations. On March 19, 2024, we announced that the DREAM pivotal trial met its primary endpoints. For more information see "-Clinical Results and Studies-Pivotal DREAM Trial" below. On August 8, 2025, the FDA approved the Genio system for a subset of patients with moderate to severe OSA with an AHI of greater than or equal to 15 and less than or equal to 65.

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In July 2022, we announced that the FDA approved an IDE to enable us to initiate a clinical trial, called ACCCESS, to evaluate the use of the Genio system for the treatment of adult patients with moderate-to-severe OSA with CCC that have failed, did not tolerate, or refused PAP. In the ACCCESS trial, we planned to implant up to 106 subjects with co-primary efficacy endpoints of AHI responder rate, per the Sher criteria, and ODI responder rate, both assessed at twelve months post-implant. In the third quarter of 2025, enrollment of new patients was stopped prior to enrolling all 106 potential patients. We anticipate initial readout of the twelve months post-implant data in the third quarter of 2026.

We initially targeted markets in Europe where we identified a country-specific reimbursement pathway or execution strategy. We began our commercial launch in Germany in July 2020. After obtaining reimbursement approval in Germany through the existing HGNS special innovation funding program, or NUB, we generated our first revenue in the second half of 2020. In 2021, we successfully obtained reimbursement in Germany under a dedicated DRG code for HGNS and obtained reimbursement under an OSA-specific DRG code in Switzerland from the Federal Statistic Office, or BFS, following which we expanded commercialization into Switzerland. The reimbursement coverage in both Germany and Switzerland includes the cost of the Genio system, implant procedure, hospital stay and follow-up care. Additionally, we expanded commercialization into Spain in 2021, Finland in 2022, Austria in 2023, and England in December 2024. In England, we obtained coverage under the NHS Specialised Services Devices Programme, or SSDP. In August, September and December 2025, we began commercialization in the United States, Abu Dhabi and the Netherlands, respectively. In the United States, reimbursement for HGNS is supported through established procedural coding and payer coverage policies. Medicare coverage is generally determined at the local level through Local Coverage Determinations, or LCDs, and related billing and coding guidance issued by regional Medicare Administrative Contractors, with coverage criteria and administrative requirements that can vary by jurisdiction. Commercial coverage is determined by individual private insurers and typically follows technology assessment and clinical evidence review, resulting in variation across plans and geographies. As commercialization progresses, we continue to engage with public and private payers, providers, and relevant stakeholders to support appropriate coverage and patient access, including through ongoing clinical evidence generation, provider education, and health economic and outcomes data development.

Based on market access activities conducted by us over the past several years, we have developed tailored reimbursement strategies using assessments of the local requirements of target countries. In countries where there is existing reimbursement coverage in place, we plan to piggyback on existing coding and reimbursement, acting as a fast follower. In countries where there is no existing reimbursement coverage, we will seek to be the first in that market to obtain reimbursement coverage. In countries without existing reimbursement coverage, the strategy could include (i) making the Genio system commercially available for patients through country specific innovation funding pathways for procedures and products that would not yet be covered by an existing code, (ii) supporting case-by-case funding submission in focus hospitals that can use their budget to fund the therapy, (iii) entering into specific commercial deals with privately funded hospital groups, or (iv) out-of-pocket payment.

We have established a systematic approach to commercializing the Genio system in our target markets, focusing on active engagement, education and market development across patients, physicians and hospitals. We currently market our therapy to physicians and hospitals where ear, nose, and throat doctors, or ENTs, sleep doctors and general practitioners see, diagnose and treat patients with OSA. We are actively expanding our sales and marketing organization with country-specific sales teams established in connection with obtaining reimbursement. Our sales teams are focused on prioritizing high volume ENT centers and sleep centers, and on building long-standing relationships with key physicians such as sleep doctors, ENTs and general practitioners who have strong connections to the OSA patient population that may be eligible for our therapy. We also seek to establish long-term partnerships with key opinion leaders, or KOLs, and patient associations that are oriented towards the needs of our patients. Our sales and marketing organization is focused on building physician awareness through referral network development, education, targeted KOL development and training, and direct-to-consumer marketing.

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In addition to our ongoing clinical studies, we are also committed to continuing our research and development efforts related to the Genio system, with an emphasis on improving clinical outcomes, optimizing patient adoption and comfort, increasing access for a greater number of patients, and allowing more physicians to perform the implantation procedure. The primary focus of our research and development efforts in the near-term will be the continued technological advancement of the Genio system. Some of these improvements include features aimed at enhancing a physician's ability to monitor patient compliance and therapeutic efficacy. The Genio 2.1 system further reflects such improvements and is designed to improve patient comfort and compliance with a new smartphone application and an upgraded external activation chip. The Genio 2.1 system offers patients daily feedback on therapy usage and the autonomy to adjust stimulation amplitude within pre-defined boundaries. Physicians can also fine-tune stimulation amplitude to determine the optimal level of comfort for patients without compromising therapy efficacy. In the long term, including through our partnership with Vanderbilt University, we intend to provide new neurostimulation technologies for OSA patients. We continue to enhance our scalable technology platform to allow for quick and streamlined release of new features and functionalities through software, firmware and hardware updates and upgrades and therapy enhancement, and anticipate making regulatory submissions relating to our Genio system in the upcoming year.

**Recent Developments**

***Private Placement***

On November 13, 2025, we entered into subscription agreements, or the Subscription Agreements, with certain investors, or the Investors, including certain institutional investors. The Subscription Agreements related to the issuance of and subscription to ordinary shares in a private placement, or the Private Placement, at a subscription price per share of €4.00, for aggregate gross proceeds of approximately €17.0 million. The Private Placement closed in two tranches on November 18, 2025 and November 20, 2025.

The ordinary shares issued and subscribed to in the Private Placement were not registered under the Securities Act of 1933, as amended, or the Securities Act. Certain of the ordinary shares were offered in a private placement to non-U.S. Persons (as such term is defined under Rule 902 of Regulation S under the Securities Act, or Regulation S) in a transaction outside the United States pursuant to Regulation S. The remaining ordinary shares were offered in a private placement to U.S. Persons (as such term is defined under Rule 902 of Regulation S) pursuant to the exemption provided in Section 4(a)(2) of the Securities Act. Each U.S. investor is an "accredited investor" (as such term is defined in Rule 501(a)) or "qualified institutional buyer" (as such term is defined in Rule 144A) under the Securities Act.

The form of Subscription Agreement is filed hereto as Exhibit 4.18, and the foregoing description of the terms of the Subscription Agreements is qualified in its entirety by reference to such exhibit.

***Registered Direct Offering***

On November 13, 2025, we entered into a Securities Purchase Agreement, or the Purchase Agreement, with certain investors, or the RDO Investors, including certain institutional investors, pursuant to which we agreed to issue and sell, in a registered direct offering, or the Registered Direct Offering, ordinary shares to the RDO Investors, at a price of U.S.$4.6304 per share, for aggregate gross proceeds of approximately U.S.$5.6 million before deducting related offering expenses.

The ordinary shares were offered pursuant to a Registration Statement on Form S-3 (File No. 333-268955), which was filed with the Securities and Exchange Commission, or the SEC, on December 22, 2022 and was declared effective by the SEC on January 6, 2023, or the Registration Statement.

The Securities Purchase Agreement contained customary representations, warranties and agreements, customary conditions to closing, other obligations of the parties and termination provisions. No underwriter or placement agent participated in the Registered Direct Offering. The Registered Direct Offering closed on November 18, 2025.

The form of Securities Purchase Agreement is filed hereto as Exhibit 4.19, and the foregoing description of the terms of the Securities Purchase Agreement is qualified in its entirety by reference to such exhibit.

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***Bonds Offering***

On November 13, 2025, we entered into a Subscription Agreement, or the Bonds Subscription Agreement, with a certain institutional investor, or the Bonds Investor, pursuant to which we agreed to issue, and the Bonds Investor agreed to subscribe to, up to a maximum of €45.0 million in aggregate principal amount of amortizing senior unsecured convertible bonds at an 8.0% original issue discount, or the Bonds Offering, consisting of an initial tranche of €22.5 million amortizing senior unsecured convertible bonds, or the First Tranche Bonds, and, if so requested by us, a second tranche of €22.5 million amortizing senior unsecured convertible bonds, or the Second Tranche Bonds, and together with the First Tranche Bonds, the Bonds.

On December 16, 2025, we entered into an Amended and Restated Subscription Agreement, or the Amended and Restated Bonds Subscription Agreement, with the Bonds Investor, pursuant to which we agreed to, among other things, pay to the Bonds Investor, in lieu of an original issue discount, a subscription fee equal to 8.0% of the principal amount of the First Tranche Bonds and the Second Tranche, as applicable, at issuance.

In connection with the execution of the Amended and Restated Bonds Subscription Agreement, on December 18, 2025, we issued the First Tranche Bonds to the Bonds Investor pursuant to Bond Instrument, or as modified by that First Supplemental Bond Instrument dated February 2, 2026, the Bond Instrument, and paid a subscription fee to the Bonds Investor of approximately €1.8 million.

The issuance of the Second Tranche Bonds, to which the Bonds Investor is obliged to subscribe upon our request, is subject to additional closing conditions and will take place upon satisfaction of such closing conditions.

Assuming the successful issuance of the Second Tranche Bonds, the gross amount of proceeds to us from the Bonds Offering will be approximately €41.4 million. We expect to use the proceeds from the Bonds Offering for working capital and other general corporate purposes.

The Bonds, and any ordinary shares issuable upon the conversion or settlement thereof, including in connection with the amortization of such Bonds, are not being registered under the Securities Act. The ordinary shares are being offered to non-U.S. Persons (as such term is defined under Rule 902 of Regulation S) in a transaction outside the United States pursuant to Regulation S.

The First Tranche Bonds rank, and the Second Tranche Bonds shall rank, in right and priority of payment immediately after our liabilities under its existing credit facility with the European Investment Bank, or the EIB Facility, and are postponed and subordinated solely to our liabilities under the EIB Facility, except for any obligations mandatorily preferred by law applying to companies generally. The Bonds shall not be, and are not intended to be, subordinated to any present or future indebtedness, obligations or liabilities of the Issuer, whether senior, pari passu, or otherwise, other than the liabilities under the EIB Facility, except for obligations mandatorily preferred by law applying to companies generally. The First Tranche Bonds rank, and the Second Tranche Bonds shall rank, at least pari passu with all of our other present and future unsecured and unsubordinated liabilities, except for obligations mandatorily preferred by law applying to companies generally. Pursuant to the terms of the Bonds, we have agreed to not to incur additional financial indebtedness which is senior in right of payment to the Bonds.

The First Tranche Bonds will mature on the third anniversary of their issuance, and the Second Tranche Bonds will mature on the third anniversary of their issuance. We are required to pay, on the Maturity Date, all outstanding principal, together with accrued and unpaid interest.

The Bonds will amortize in 12 installments payable every three months beginning three months after the date of the Private Placement. At our option, the Company may make installment payments in cash of 103% of the applicable Amortised Payment Amount (as defined in the Bond Instrument) Alternatively, we may elect to make such Amortised Payment Amount in ordinary shares, or the Amortization Shares, which will be priced at the Relevant Share Settlement Price (as defined in the Bond Instrument), which is the lower of (a) the Conversion Price (as defined in the Bond Instrument) as then in effect and (b) 90% of the Reference Lowest Daily Market Price (as defined in the Bond Instrument) in respect of the relevant SSO Reference Date (as defined in the Bond Instrument).

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Pursuant to the Bond Instrument, the Note Investor may, on one or more occasions, exercise its right to defer any one or more Amortized Payment Amounts (as defined in the Bond Instrument) that would be scheduled for payment on a Scheduled Amortization Payment Date (as defined in the Bond Instrument) by giving notice to us at least one business day prior to such Scheduled Amortization Payment Date. The effect of the deferral is that the Amortized Payment Amount would not be payable on such Scheduled Amortization Payment Date, but instead would become payable on any subsequent Scheduled Amortization Payment Date as specified in the notice provided to us. Additionally, the Note Investor may, on one or more occasions, exercise its right to bring forward up to two payments of the Amortized Payment Amount in respect of all or some of the Bonds outstanding at such time as would otherwise be scheduled to be paid either on (i) the final maturity date or (ii) on each of the final maturity date and the immediately preceding Amortization Payment Date by giving notice to us, in which case such payments shall become payable on the date specified in the notice which shall not be earlier than two business days following the date on which the relevant notice is given.

The First Tranche Bonds bear, and the Second Tranche Bonds will bear, interest at a rate of 6.5% per annum on the outstanding principal amount of the Bonds payable in arrear every three (3) months beginning three (3) months after the date of the Private Placement.

The Bonds contain standard and customary events of default including, but not limited to: (i) our failure to pay any principal, interest, late charges, or other amounts due under the Bonds, (ii) our failure to deliver ordinary shares following any exercise of the Bonds, (iii) our failure to perform or comply in any material respect with any of its respective obligations under the covenants and undertakings conditions of the Bonds, (iv) our failure to perform or comply in any material respect with its obligations in the Bonds or the Bond Documents (as defined in the Bonds), (v) our default under, or the occurrence of certain events of default or other violations of the terms of, the other existing indebtedness, (vi) bankruptcy, reorganization or liquidation events, (vii) material breaches of our representations, warranties and covenants in the Amended and Restated Bonds Subscription Agreement. In the event of an event of default, the Bonds would be subject to redemption in an amount that is the sum of (i) the Make-Whole Premium (as defined in the Bond Instrument) and (ii) an amount equal to the greater of 120% of the principal amount of Bonds outstanding on the relevant date and the relevant Parity Value (as defined in the Bond Instrument) of the Bonds.

In connection with a Change of Control (as defined in the Bond Instrument), we must provide notice to the Bonds Investor within five (5) business days following the occurrence of the Change of Control. If the Bonds Investor elects to convert its bonds after the occurrence of a Change of Control, we must ensure the Bonds Investor will receive the same consideration for ordinary shares arising on such exercise as it would have received had such shares been submitted into, and accepted pursuant to the relevant offer in connection with the Change of Control. In the event of a Change of Control, the Bonds would be subject to redemption in an amount that is the sum of (i) the Make-Whole Premium (as defined in the Bond Instrument) and (ii) an amount equal to the greater of 120% of the principal amount of Bonds outstanding on the relevant date and the relevant Parity Value (as defined in the Bond Instrument) of the Bonds.

In addition, in the case of a Change of a Control, if the Change of Control Resolutions (as defined in the Bond Instrument) are not passed before the Longstop Date (as defined in the Bond Instrument) and filed with the Belgian authorities, the Bonds Investor will have the right to require the Company to redeem in cash (or shares, at the Bonds Investors' election) the Note.

In connection with a De-Listing Event or Free Float Event (each as defined in the Bond Instrument), the Bonds would be subject to redemption in an amount that is the sum of (i) the Make-Whole Premium (as defined in the Bond Instrument) and (ii) an amount equal to the greater of 120% of the principal amount of Bonds outstanding on the relevant date and the relevant Parity Value (as defined in the Bond Instrument) of the Bonds.

The Bonds contain a variety of obligations to not engage in specific activities, which are typical for transactions of this type, including the following covenants:

● we will not (directly or indirectly) create or permit to subsist any mortgage, charge, pledge, lien or other security interest securing any obligation of any person or any other agreement or arrangement having a similar effect (a "Security Interest") without securing the obligations of the Company under the Bonds equally ratable therewith or providing other security, guarantees or arrangements for the benefit of the Note holders as may be approved by holders of at least 90 per cent in principal amount of the Note then outstanding, with the exception of certain permitted Security Interests described in the Bonds;

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● we will not (directly or indirectly) create, incur, assume or otherwise become liable in respect of any financial indebtedness which (i) by their terms carry rights of conversion into, or exchange or subscription for, or the right to otherwise acquire, ordinary shares of the Company or its subsidiaries, (ii) by their terms limit or prohibit any of the terms of the Bonds, including any prohibition of payment of cash pursuant to the bonds, any limitation on the ability of the Bonds Investor to exercise its conversion rights with respect to the Bonds or any limitation on the ability of the Company to deliver ordinary shares in respect of any share settlement, and (iii) by their terms would rank senior to the Bonds in right of payment;

● we will not enter into a transaction or series of transactions to sell, lease, transfer or otherwise dispose of assets or enter into any amalgamation, demerger, merger, consolidation or corporate reconstruction, subject to certain exceptions;

● we will not enter into any transactions with affiliates, unless on terms that could be obtained in an arm's-length transaction;

● we will not cause or permit to exist any consensual encumbrance or restriction on the Company's ability to perform and comply with its obligations under the Bonds;

● we will use our best efforts to, among other things, ensure that any Change of Control Resolutions are presented to the shareholders before the Longstop Date; and

● we will not amend, modify or vary any term of its existing EIB Facility or enter into any new agreements, instruments or other arrangements with the European Investment Bank that could reasonably be expected to impair, restrict, prohibit or limit the Company's ability to perform its obligations under the Bonds.

The Bonds also contain certain additional ongoing obligations, including the obligation (i) to make periodic filings within specified timeframes as detailed in the Bonds Instrument, (ii) to provide the Bonds Investor with an officer's certificate in connection with the Company's periodic filings and (iii) to comply in all material respects with applicable laws and regulations.

The Bonds Subscription Agreement, Amended and Restated Bonds Subscription Agreement, Bond Instrument and First Supplemental Bond Instrument are filed hereto as Exhibits 4.20, 4.21, 4.22 and 4.23, respectively, and the foregoing descriptions of the terms of the Bonds Subscription Agreement, Amended and Restated Bonds Subscription Agreement, Bond Instrument and First Supplemental Bond Instrument are qualified in their entirety by reference to such exhibits.

**Our Competitive Strengths**

We are focused on transforming the lives of patients who suffer from moderate to severe OSA by continuing to develop, clinically validate, manufacture and commercialize our innovative Genio system. We believe the Genio system offers a compelling solution for a large and significantly underpenetrated global patient population and that our focus and experience in treating patients with OSA, combined with the following strengths, will allow us to build our business and potentially expand our market opportunity:

●  ***Disruptive, patient-centric neurostimulation solution to treat moderate to severe OSA.*** We specifically designed the Genio system with the goal of advancing a therapy to treat moderate to severe OSA and providing a safe and effective patient-centric solution intended to offer benefits to address the unmet needs of patients. The Genio system includes the first leadless, externally powered neurostimulator designed to be implanted in a single-incision procedure. The Genio system delivers bilateral HGNS for patients who suffer from moderate to severe OSA and did not tolerate, failed or refused standard first-line therapies, including CPAP. We believe that bilateral stimulation could lead to improved therapeutic performance compared to other HGNS-based technologies. While other commercially available neurostimulation platforms require implantation of leads and a pulse generator containing a battery, our Genio system only requires implantation of a battery-free neurostimulator. Due to its unique design, the Genio system's implantable stimulator is currently the only neurostimulation-based OSA therapy with MR conditional labeling for full-body MRI scans at both 1.5T and 3T under its CE Mark and FDA approvals. Conditional labeling for MRI scans has become increasingly important for physicians and patients due to the growing need and incidence of MRI scans. Implantable medical devices that have not been tested and approved with MR Conditional labeling are considered as MR Unsafe, and MR scans are contraindicated for these patients. We believe our Genio system technology has the potential to become an important meaningful solution for many of the estimated 425 million diagnosed and undiagnosed OSA patients worldwide suffering from moderate to severe OSA.

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●  ***Growing body of clinical data and long-term clinical strategy.*** The Genio system is predicated on a well-established mechanism of action of electrically stimulating the hypoglossal nerve. Our BLAST OSA trial provided positive data for the Genio system, demonstrating that treatment with the Genio system resulted in statistically significant improvements in sleep apnea symptoms and quality of life measures. These data results were also associated with high therapy compliance. The trial's results supported receipt of the CE-Mark in 2019 and have been published in peer-reviewed journals, including the European Respiratory Journal. We are continuing our clinical research to evaluate the efficacy of the Genio system on a longer-term basis through our post-market clinical trial for the treatment of OSA in adults, or the EliSA trial. In December 2020, we implanted the first patient in the DREAM trial, which was designed to support marketing authorization in the United States. In addition, in June 2021, we announced initial top-line results from the six-month data for the BETTER SLEEP trial. Based on this data, in October 2021, we expanded the CE-Marked indication to include OSA patients with CCC, which should eliminate the need for a DISE procedure. In September 2021, we received breakthrough device designation in the United States for the Genio system from the FDA for the treatment of OSA with CCC, based on the initial clinical evidence from the BETTER SLEEP trial. Further, in June 2022, we announced that the FDA approved the use of our next generation Genio 2.1 system for use in the DREAM trial. In June 2023, we presented 12-month data on the first 34 DREAM patients reaching 12-month follow-up as a late-breaking abstract at SLEEP 2023, a joint meeting of the American Academy of Sleep Medicine and the Sleep Research Society, demonstrating a 65% AHI responder rate, a 76% ODI responder rate and safety in line with expectations. On March 19, 2024, we announced that the DREAM pivotal trial met its primary endpoints. The DREAM trial results were published in the Journal of Clinical Sleep Medicine in July 2025. For more information see "-Clinical Results and Studies-Pivotal DREAM Trial" below. Additionally, in July 2022, we announced that the FDA approved an IDE to enable us to initiate a clinical trial, called ACCCESS, to evaluate the use of the Genio system for the treatment of adult patients with moderate-to-severe OSA with CCC that have failed, did not tolerate, or refused PAP. Enrollment of new patients was stopped in the third quarter of 2025 and we anticipate initial readout of the twelve months post-implant data in the third quarter of 2026.

●  ***Active product development and expanded indications pipeline .*** The Genio system is a scalable-technology platform that allows for future external hardware, software and firmware updates to enhance therapeutic capabilities without requiring additional surgical procedures. We continue to invest in improving the Genio system to develop next generation products with features designed to improve patient comfort and compliance, therapy efficacy and patient and market acceptance. Some of these improvements include features aimed at enhancing the physician's ability to monitor patient compliance and therapeutic efficacy, including sensor technology to monitor a patient's sleep position. We are also committed to expanding current treatment options for moderate to severe OSA patients by developing next generation neurostimulation-based technologies. We previously entered into a licensing agreement with Vanderbilt University pursuant to which we are exploring additional neurostimulation technologies. Under the agreement, we have an exclusive, worldwide license to make, use, sell or distribute products for treating sleep disordered breathing covered by certain patent rights owned, or that may be owned, by Vanderbilt. We will also work together with Vanderbilt University to continue prosecution of patent applications made by Vanderbilt.

●  ***Platform technology protected by comprehensive and broad intellectual property.*** Our platform technology is supported by a strong and growing portfolio of intellectual property rights, which includes utility and design patents, know-how and trade secrets, including therapy protocols, electrodes and methods. As of December 31, 2025, we had 301 granted patents (including 57 granted U.S. patents) and 36 pending patent applications (including eight pending U.S. patent applications), and we were the owner of 33 trademark registrations (including four international trademark registrations for which protection was granted in the United States).

●  ***Strong and experienced team.*** Our senior management team has many years of experience in the healthcare and medical device industry. Specifically, our team has extensive operating experience in product development, clinical, regulatory approval and commercialization activities as well as established relationships with industry leaders in the academic, clinical and commercial neuromodulation industries. Members of our management team have served in leadership positions with well-regarded medical technology companies such as St. Jude Medical Inc., Medtronic Inc., Stryker Corp and Nevro Corp. Since our founding, we have been supported by a seasoned Board of Directors with extensive industry and public company experience and a Scientific Advisory Committee that consists of industry-relevant KOLs.

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#### Our Strategy
Our mission is to become a global leader in providing innovative, clinically proven solutions to treat patients suffering from OSA. The key elements of our strategy to achieve this goal and promote future growth include:

●  ***Marketing authorization in the United States .*** On August 8, 2025, the FDA approved the Genio system for the treatment of moderate to severe OSA in adult patients with an AHI of greater than or equal to 15 and less than or equal to 65. We immediately commenced U.S. commercialization with a phased rollout at early-adopter centers, onboarding sites, and completing surgeon training. As a condition of the PMA approval, we plan to complete a post-approval clinical study named BREATHE (Bi-lateral HGN Therapy in Real-World Patients -Post Approval Research Investigation), which is expected to enroll 229 patients (with a minimum of 160 evaluable patients).

●  ***Promoting awareness of the Genio system among physicians, patients and payors to accelerate market adoption.*** We believe that the Genio system has the potential to become a meaningful neurostimulation solution for moderate to severe OSA patients. To accomplish this, we intend to raise market awareness and educate physicians, payors and patients on the negative impact of OSA and position the Genio system as a safe and effective treatment option for moderate to severe OSA patients. We currently offer education and training programs to sleep centers and surgeons, which are intended to provide a better understanding of the Genio system's unique features and support surgeons' confidence implanting our technology. In addition, we provide programs targeted towards patients who use the Genio system to promote and increase their engagement and long-term use, with a focus on patient experience. We intend to establish long-term partnerships with KOLs, ENTs and sleep scientific societies and patient associations that are built on mutual trust and oriented towards the needs of OSA patients and their families. Finally, we intend to establish relationships with government and commercial payors to help reduce barriers to treating OSA by highlighting our clinical data, costs affiliated with untreated OSA patients and the clinical profile of the Genio system. We plan to build upon this multi-pronged approach with direct-to-consumer marketing initiatives that help to educate patients and may result in patient leads.

●  ***Continuing to enhance the Genio system and expand its indications.*** We continue to invest in our solutions and services to further improve the implantation procedure and enhance the patient experience and product features. Potential feature improvements could include design alterations, information driven integrated capabilities, diagnostics or monitoring, sleep apnea testing or various other technological advancements. We believe that bilateral stimulation could lead to better therapeutic performance and address more therapeutic indications compared to other hypoglossal nerve stimulation-based technologies. In June 2021, we announced initial top-line results from the six-month data for the BETTER SLEEP clinical trial. Based on this data, in October 2021, the EU Notified Body expanded the CE Marked indication to include OSA patients with CCC for the Genio system in Europe. Currently, CCC patients are contraindicated for other HGNS therapies.

As part of our ongoing development efforts, in July 2022, we obtained CE Mark approval for the Genio 2.1 system, which included updates designed to enhance the patient experience. Also in July 2022, we announced that the FDA approved an IDE to enable us to initiate a clinical trial, called ACCCESS, to evaluate the use of the Genio system for the treatment of adult patients with moderate-to-severe OSA with CCC that have failed, did not tolerate, or refused PAP. Enrollment of new patients was stopped in the third quarter of 2025 and we anticipate initial readout of the twelve months post-implant data in the third quarter of 2026. In addition, we may look for strategic opportunities, including partnerships or collaborations, to broaden our capabilities and expertise in line with our patient-centric vision.

●  ***Pursuing and establishing favorable reimbursement coverage of the Genio system.*** While there is consensus among physicians and payors of the medical necessity to treat OSA and increase the number of HGNS therapy coverage decisions, we continue to develop further clinical evidence intended to demonstrate a long-term meaningful improvement in health outcomes for patients meeting the specified criteria. We initially targeted markets in Europe where we identified a clear reimbursement pathway or execution strategy. In Germany, we have successfully obtained reimbursement under a dedicated DRG code for HGNS. In Switzerland, we obtained reimbursement under an OSA-specific DRG code by the Federal Statistic Office, or BFS. Each of these reimbursement coverages includes the cost of the Genio system, implant procedure, hospital stay and follow-up care. In August, September and December 2025, we began commercialization in the United States, Abu Dhabi and the Netherlands, respectively. We believe that establishing and maintaining reimbursement will be important in achieving broad acceptance of our system by healthcare providers in these markets.

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●  ***Continuing to build a commercial infrastructure in selected geographies.*** We have grown our European commercial team to more than 20 people, including sales representatives, field engineers and marketing professionals, who collectively bring medical device sales, education and clinical experience to support commercialization of the Genio system. Our initial strategy is to employ a targeted approach to increase therapy penetration within specific physician practice groups instead of a broad outreach strategy to physicians in general. Our sales and marketing organization is focused on prioritizing high volume centers that are strategically located and building long-standing relationships with key physicians with strong connections to the population of OSA patients indicated for the Genio system. We are focusing our efforts on developing Centers of Excellence in each of our commercial markets, where we plan to invest in developing the Genio system as the preferred treatment option for indicated moderate to severe OSA patients. Using a direct commercialization model in most of our target countries, we plan to utilize account managers to support these Centers of Excellence to strengthen the referral physician network, guiding new patients to these Centers of Excellence. We expect to gradually scale up our commercial organization in line with market entry and access in the various countries that we are targeting. Based on our experience gained from the commercial roll-out in Europe, but also taking into account particular dynamics of the local markets, we will determine and prepare what we believe to be the optimal sales and marketing structure for commercial launch in each market. In the United States, we plan to utilize a direct sales organization initially focused on the top 400 HGNS accounts which we believe account for approximately 70%-75% of all HGNS procedures in the United States. As of December 31, 2025, we had over 50 people in our commercial organization in the United States, of which 25 are sales representatives or territory managers that are supported by clinical education specialists, pre-authorization and reimbursement support personnel, customer service, marketing resources and leadership. Each sales representative or territory manager can support four to six customer accounts, which means we can cover approximately 125 of the top 400 HGNS accounts in the United States. We expect to expand the number of sales representatives by hiring in groups of 15 on a basis until we reach a total of 85 sales representatives or territory managers which will allow us to cover the top 400 HGNS accounts in the United States. In the first quarter of productivity, the fourth quarter of 2025, our initial class of 25 sales representatives generated on average $700,000 in annualized revenue in the United States per sales representative. For the full year 2026, we expect that this initial class of 25 sales representatives will generate on average $1.0 million to $1.2 million in annual sales revenue per sales representative, and at full productivity, we expect a sales representative to generate over $2.0 million per year in revenue.

#### Market Overview

#### Overview of Obstructive Sleep Apnea
OSA is the most prevalent sleep disordered breathing condition. It is estimated that OSA currently affects approximately 936 million people globally between the ages of 30 and 69, of which approximately 425 million people suffer from moderate to severe OSA and require treatment. Every year, there are over 5.3 million new patients diagnosed with moderate to severe OSA, representing approximately 2.6 million in the United States and 2.6 million in our initial target markets in Europe.

OSA occurs due to the relaxation of the soft tissue, throat and tongue muscles in a patient's airway causing an obstruction that temporarily prevents breathing during sleep. In patients with OSA, the airway repeatedly becomes partially or completely blocked thereby limiting the airflow reaching the lungs to sufficiently oxygenate the blood. During an obstruction, the patient's oxygen level in the blood, or SpO2, drops, causing an increase of their Oxygen Desaturation Index, or ODI, leading to significant and repeated sleep interruptions. The lack of airflow can last anywhere from ten seconds to more than a minute and, in severe cases, may occur 30 or more times during an hour of sleep. When the airway becomes blocked, the brain detects a stress signal from various biological sources including the chest muscles, lungs and, at times, a drop in blood oxygen content that causes the individual to awaken unconsciously, just enough to tighten the airway muscles and allow normal breathing to resume. A hypopnea is a partially blocked airway; apnea is a fully blocked airway. While regular breathing is restored temporarily, the obstruction typically occurs again, which restarts the apnea cycle. This cycle of obstructions and waking can repeat dozens of times per hour throughout the night, disrupting the rapid eye movement and deep, restorative sleep that are critical to maintaining good health. The overall quality of a patient's sleep, health and quality of life are diminished.

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The total number of apneas and hypopneas per hour of sleep is referred to as the Apnea-Hypopnea Index, or AHI. The severity of OSA is based on the following four AHI categories and corresponding events per hour:

---

| | |
|:---|:---|
| Categories | AHI Range |
| Normal Range | <5 Events Per Hour |
| Mild OSA | 5-14 Events Per Hour |
| Moderate OSA | 15-30 Events Per Hour |
| Severe OSA | >30 Events Per Hour |

---

The figure below illustrates the physiologic blockage experienced by patients with OSA.

![Graphic](nyxh-20251231x20f001.jpg)

Moderate to severe OSA patients require a dedicated therapy according to published guidelines by sleep doctors' scientific societies such as the American Academy of Sleep Medicine. If left untreated, OSA is associated with increased mortality risk and significant comorbidities, including cardiovascular diseases, depression and stroke.

#### Symptoms and Diagnosis of OSA
OSA is a serious and chronic sleep breathing disorder that negatively impacts a patient's sleep, health and quality of life. Due to the poor quality and lack of sleep, OSA patients often feel tired and fatigued during the day. They may find it difficult to concentrate and experience emotional stress, including depression. Patients struggling with OSA are typically unaware of their condition as OSA remains significantly underdiagnosed. While sleep apnea has traditionally been perceived as a lifestyle disease, with snoring and tiredness as the main implications, it is now known to be a major underlying risk factor and disease progression accelerator for most cardiovascular diseases and many cognitive and neurodegenerative diseases. Despite the increased availability of diagnostic technology, approximately 80% of people in the United States suffering from sleep apnea are undiagnosed. In recent years, increased awareness of the importance of sleep and the devastating potential consequences of sleep apnea have been on the rise in medical communities, and among patients and patient association groups.

Common first indicators of OSA are a patient's heavy snoring, excessive daytime sleepiness, headaches, depression, memory or concentration problems, nighttime gasping and dry mouth or sore throat. The impact of heavy snoring creates unrest for both the patient and the patient's bed partner and often drives the patient to obtain medical advice and potential diagnosis. Once a physician makes a preliminary diagnosis, the patient may undergo an in-lab sleep trial, or a home sleep apnea test, or HSAT, to obtain a clinically validated diagnosis of OSA. An in-lab sleep trial requires the patient to stay overnight at a sleep center, where nasal air tubes and sensors, electrodes and wires are attached to various parts of the body, including the head, chest and abdomen. The system of monitors and sensors measure the patient's airflow, sleep quality, blood oxygen levels and breathing patterns. More recently, sleep doctors and cardiologists have begun prescribing HSAT in lieu of an in-lab sleep trial to help diagnose OSA. HSATs are low-cost, self- administered portable devices that allow patients to be tested in the comfort of their own homes while offering greater ease of use. Data is collected, downloaded and interpreted by a board-certified sleep physician. While an in-lab sleep trial is currently considered the standard of care for OSA diagnosis, we expect HSAT acceptance and utilization to continue to increase thereby reducing the percentage of undiagnosed OSA patients.

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#### Comorbidities Associated with OSA
OSA may also be associated with severe medical comorbidities, including coronary artery disease, cardiac arrhythmias such as atrial fibrillation, heart failure, hypertension, obesity, stroke and Type 2 diabetes.

The following graphic summarizes the high prevalence of OSA in key chronic diseases.

![Graphic](nyxh-20251231x20f002.jpg)

Several peer-reviewed, published studies have shown that sleep apnea is a direct contributing factor to the incidence of various forms of cardiovascular disease. Cardiovascular disease is highly prevalent and, often, a severe and potentially fatal medical condition. There is increasing awareness among cardiologists and the general population of the importance of sleep apnea in the causation or promotion of hypertension, coronary artery disease, heart failure, atrial arrhythmias and strokes, and, consequently, a predictor of premature cardiovascular disease.

Published clinical literature, including an 18-year mortality follow-up trial at the University of Wisconsin, has demonstrated strong correlation between OSA and the risk of mortality. Based on the 1,522-person Wisconsin Sleep Cohort sample, participants with untreated moderate and severe OSA experienced a significant impact on mortality with survival rates of approximately 85% and 60%, respectively. Untreated OSA can be deadly, as untreated OSA patients have two times more risk of suffering stroke, two and a half times more risk of heart failure and five times more risk of cardiovascular mortality. Numerous studies have demonstrated the correlation between efficient OSA therapy and the reduction of mortality and comorbidities.

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The chart below illustrates the significant impact on mortality and survival rates over time based on severity of OSA.

![Graphic](nyxh-20251231x20f003.jpg)

#### Economic Costs of Untreated OSA
The socio-economic burden of OSA stems from both direct and indirect health costs. According to a Harvard Medical School trial published in December 2010, the annual economic cost of unmanaged OSA was estimated to be $67 billion to $165 billion based on total direct healthcare costs, incremental healthcare costs from comorbidities, non-medical traffic accident-related costs due to increased fatigue, non-medical workplace accident-related costs, OSA-driven job absenteeism costs and other family-related and other societal costs. This amount is greater than the estimated annual economic cost in the United States of asthma, heart failure, stroke and hypertensive disease, each estimated at $20 to $80 billion annually.

The direct costs associated with OSA include the costs for diagnosis and treatment and associated medical conditions, several of which also result in impaired work productivity and road traffic accidents that give rise to indirect health costs. People with unmanaged OSA are about two to three times more likely to have a traffic accident. OSA is associated with an increase in the rate and severity of motor vehicle accidents, increased healthcare utilization, reduction of work performance and occupational injuries.

#### Existing Treatments for OSA
There are several treatment options available to OSA patients, including medical management, involving lifestyle changes such as weight loss, CPAP therapy, mandibular advancement devices, or MADs, surgical interventions, and advanced neuromodulation devices.

*CPAP*

CPAP is a treatment whereby air, at a constant or automated pressure, is pushed into the upper airway via a facial or nasal mask that the patient must wear all night. CPAP has demonstrated efficacy in reducing AHI, as well as improving patient sleep quality and daytime sleepiness. Since its introduction in the 1980's, CPAP therapy has been the first-line therapy for OSA patients of all severities. However, the efficacy of CPAP therapy is directly correlated to the number of hours of use per night and its long-term compliance.

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Poor patient compliance and discomfort have been major factors in the efficacy of CPAP treatment. Patients often struggle with sustained regular use of the CPAP device due to mask discomfort, mask leakage, pressure intolerance, skin irritation, nasal congestion, nasal drying, nosebleeds, claustrophobia and lack of intimacy. In addition, the airway pressure can cause severe dryness in the nose and mouth, resulting in the sense of suffocation and nasal congestion. Medicare defines compliance as using a CPAP device at least four hours a night for 70% of nights during any consecutive 30-day period within the first three months of initial usage. CPAP non-compliance is estimated to be between 29% and 83%, and we estimate the CPAP non-compliance rate to be approximately 35%.

*Oral Appliances — Mandibular Advancement Devices*

MADs are similar to orthodontic retainers and are intended to diminish restrictions that occur in the back of the throat by moving the jaw and tongue forward to increase the size of the upper airway and reduce the air resistance that leads to snoring. These devices are utilized nightly by patients. Due to their form factor, MADs have multiple limitations, including tooth and jaw pain, potential tooth displacement and recurrent dental follow-ups. According to published literature, MADs generally provide unpredictable therapy efficacy.

*Surgery to Remove or Reposition Patient Tissue or Bone*

For patients who have difficulties utilizing or complying with CPAP and MADs, invasive surgical procedures for the nose, throat or mandible, such as uvulopalatopharyngoplasty, or UPPP, and maxillomandibular advancement, or MMA, can be beneficial alternatives. Surgery is suggested to patients with specific anatomical conditions, but this is a highly invasive procedure that irreversibly alters the patient's anatomy, requires extended and painful recovery periods, and has only moderate efficacy. For example, MMA involves enlarging the airway by surgically moving the upper jaw (maxilla) and lower jaw (mandible) forward. The surgical procedure can last up to four or five hours and the patient can only return to work after four to five weeks. Therefore, surgical procedures are often considered as last resort options, due to their invasiveness, cost, the high incidence of side effects and varying responder rates, which are estimated to be between 30% and 60%.

*Drugs to treat Obstructive Sleep Apnea*

In 2024, some studies were published demonstrating a positive effect of GLP-1 receptor agonists, such as Mounjarno (Tirzepatide), on OSA in obese adult patients.

These drugs (such as Zepbound - Eli Lilly) are now indicated in the United States for the treatment of OSA in obese patients. In Europe, the EMA (European Medicines Agency) has determined that Eli Lilly's Mounjaro (Tirzepatide) existing indication for weight management already encompasses it benefits for OSA in adults with obesity, making a separate indication unnecessary.

We expect drugs like Mounjaro (Tirzepatide) to potentially enlarge the pool of patients eligible to hypoglossal nerve stimulation by reducing the BMI of obese patients and allowing them to meet the indication criteria for hypoglossal nerve stimulation. However, we have not experienced the benefit of this impact to date.

*Hypoglossal Nerve Stimulation, an Established Approach to Treat OSA*

Over the last decade, technologies focused on the stimulation of the hypoglossal nerve have emerged as an alternative treatment option for moderate to severe OSA patients who refused, do not tolerate or are not compliant with conventional CPAP therapy. The hypoglossal nerve controls the tongue and airway muscles. By stimulating the hypoglossal nerve, these therapies trigger the contraction of the tongue muscles and thereby help maintain an open airway during sleep.

Many countries, including the Netherlands, Germany, Switzerland and the United States, already recognize the benefits of HGNS as a therapy for moderate to severe OSA and have provided requisite reimbursement for the therapy.

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#### Limitations of Competing Hypoglossal Nerve Stimulation Devices
We are aware of two competing HGNS devices for use in treating patients with OSA. The most widely-used HGNS device is the Inspire system. The Inspire system consists of a remote control and up to three implantable components: a pressure sensing lead, which detects when the patient is attempting to breathe (in Inspire IV system only); a neurostimulator, which houses the electronics and battery power for the device; and a stimulation lead, which delivers electrical stimulation to one branch of the hypoglossal nerve. A more recently introduced version of the Inspire system now consists of two implantable components, removing the pressure sensing lead from the system. The other device is similar to the Inspire system, but its implantable pulse generator uses only one lead and contains a rechargeable battery.

While the benefits of HGNS have been well-recognized, we believe competing HGNS solutions have a number of limitations, including:

● *Neurostimulator with Internal Battery* 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Competing neurostimulation systems for the treatment of OSA rely on an implanted neurostimulator that includes an internal battery.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o In most cases, the internal battery cannot be recharged and, once depleted, the neurostimulator must be replaced in a further surgical procedure. In some cases, the battery can be recharged by the patient but will eventually become depleted and require surgery to be replaced. Additional surgical procedures carry inherent risks.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o The neurostimulator has been designed to be large enough to accommodate the additional space necessary for the battery. As a result, the neurostimulator is positioned in a subcutaneous pocket, and the device may be palpable or visible in the chest area.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Given the design of the implanted neurostimulator used by competing systems that are based on a pacemaker platform, those systems are either labeled as MR Conditional at 1.5T only or are MR Unsafe (meaning patients with those devices cannot undergo MRI scans). By contrast, the Genio system is labeled as MR Conditional for full-body MRI scans at both 1.5T and 3T.

● *Multiple Implantable Components Requiring Multiple Surgical Incisions* 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Competing systems require multiple parts to be implanted including an implantable pulse generator (IPG) and, depending on the version of the system, one or two leads;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Competing systems require multiple surgical incisions and subcutaneous lead tunneling including bringing a lead from the pulse generator to the neck and, depending on the version of the system, bringing a lead from the pulse generator to the respiratory system, which monitors breathing. These additional steps increase the complexity and number of surgical steps involved in the implantation procedure.

● *Unilateral Stimulation* 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Unilateral stimulation delivers stimulation to only one branch of the hypoglossal nerve, which limits options for nonresponding or contraindicated patients, including patients with CCC.

#### The Genio System Market Opportunity
Despite the availability of diagnostics and device-based and surgical treatments, the market for OSA therapy remains highly underpenetrated. OSA is the world's most common sleep disordered breathing condition, affecting approximately 936 million people between 30 and 69 years of age globally, of which an estimated 425 million suffer from moderate to severe OSA and require treatment. According to the 2019 Lancet Respiratory Medicine Journal, the estimated prevalence of moderate to severe OSA patients between 30 and 69 years of age in our targeted commercial markets is approximately 48.1 million people, as further detailed in the below chart.

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#### ESTIMATED MODERATE TO SEVERE OSA PREVALENCE BY COUNTRY

---

| | | |
|:---|:---|:---|
|  | <br>**Population**<br>**aged**<br>**30 – 69 years** | **Prevalence of**<br>**moderate-to-**<br>**severe OSA in**<br>**30 – 69Y old**<br>**population** |
| **United States** |  |  |
| &nbsp;&nbsp;United States | 163246772 | 23678109 |
| **Europe** |  |  |
| &nbsp;&nbsp;Germany | 43751645 | 14393964 |
| &nbsp;&nbsp;Spain | 26158266 | 4233728 |
| &nbsp;&nbsp;Netherlands | 9050266 | 2582583 |
| &nbsp;&nbsp;UK | 32936962 | 1581374 |
| &nbsp;&nbsp;Switzerland | 4518615 | 1654232 |
| &nbsp;&nbsp;**Total Europe** | **116415754** | **24445881** |

---

OSA therapy is a large and growing market. We believe there is a significant population in the United States with moderate to severe OSA who are unable to use or achieve the intended clinical benefit from CPAP and who would be eligible for the Genio system. Published scientific literature estimates that there are currently approximately 24.4 million individuals with moderate to severe OSA in our initial target markets in Europe. Based on published scientific literature, we estimate that approximately 2.6 million patients are diagnosed annually in those countries and that approximately 80% of diagnosed patients are prescribed a CPAP device. Published scientific literature reports non-compliance rates to CPAP between 29% and 83%. Based on these data, and for purposes of calculating the total addressable market in Europe for the Genio system, we estimate that approximately 35% of patients that are prescribed CPAP in those countries are not compliant with the therapy. Additionally, certain patients possess anatomical characteristics, including higher body-mass index or increased tongue fat deposition that make them ineligible for HGNS. Taking that into account, we estimate that approximately 70% of those non-compliant patients are eligible for HGNS based on their anatomical characteristics. As a result, we believe the total addressable market in Europe for the Genio system is at least 515,000 patients annually, which represents an estimated annual market opportunity of approximately $10 billion based on our current pricing for the Genio system. We are now commercial in the U.S. market, where published scientific literature estimates there are approximately 23.7 million individuals with moderate to severe OSA. Based on the same assumptions set out above, we estimate a target market of approximately 510,000 patients in the United States, which represents an estimated annual total addressable market of approximately $10 billion based on our current pricing for the Genio system.

#### Our Solution
We developed the Genio system to provide patients suffering from moderate to severe OSA with an alternative HGNS system intended to address their unmet needs. Based on clinical experience, we believe our single-incision solution has the potential to become a preferred neurostimulation treatment option for many patients suffering from moderate to severe OSA, including patients with CCC. The Genio system obtained CE Mark approval in March 2019 and FDA approval in August 2025.

#### Overview of the Genio system
The Genio system is the first neurostimulation system for the treatment of OSA to include a leadless, externally powered neurostimulator capable of delivering bilateral HGNS. The system includes an implantable component that is implanted via a single incision procedure. We developed the system using a patient-centric approach to offer patients a convenient alternative design intended to address the limitations of competing neurostimulation devices.

#### Components of the Genio system
● *Implantable Stimulator.* The implantable stimulator is the only implantable component of the Genio system. It consists of a saddle-like antenna with two legs, each containing two metal pads, called paddle electrodes. The paddle electrodes are placed in contact with both branches of the hypoglossal nerve and deliver bilateral stimulation to the hypoglossal nerve. Pulses from the stimulator trigger a slight forward movement of the posterior portion of the tongue to maintain an open airway throughout the night. The implantable stimulator is MR Conditional for full-body MRI scans at 1.5T and 3T.

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● *Activation chip.* The activation chip is a detachable, external power source for the implantable stimulator and is composed of a chipset, which provides the patient's personalized therapy program, and a rechargeable battery. The chipset is programmable which supports future updates or additional services without having to replace the implantable stimulator during an additional surgery. Patients are instructed to charge the activation chip with the charging unit after each use.

● *Disposable patch.* The disposable patch is a single-use, medical grade adhesive patch, which also contains a transmitting coil. The patch is placed on the skin under the chin each time before the patient goes to sleep. The patient attaches the activation chip to the disposable patch, which then activates the implantable stimulator. After use, the patient detaches the activation chip from the chin and disposes of the patch.

● *Charging unit.* The charging unit and its power adapter are used to charge the activation chip's battery. A fully depleted activation chip can be charged on the charging unit within 3 hours.

● *External stimulator.* The external stimulator is a sterile, single-use device that is used by the surgeon during the implantation procedure to activate and verify functionality of the implantable stimulator.

● *Sleep lab application*. The sleep lab application is used to configure the activation chip stimulation parameters. This remote application runs on a small mini-computer (repeater) and uses Bluetooth Low Energy, or BLE, protocol to enable the operator to configure/customize the activation chip stimulation parameters. Once the activation chip is connected to a disposable patch, the sleep lab application can be used to perform activation chip check-ups, read usage data stored in the activation chip, and program/adjust the stimulation parameters.

● *Smartphone application*. The activation chip can be controlled by an optional smartphone application, designed to operate on both Android and iOS devices, which allows the patient to pause and resume stimulation and to increase/decrease the treatment amplitude within a pre-configured range. The smartphone application uses BLE protocol to communicate with a paired activation chip.

#### Benefits of the Genio system
We designed the Genio system to advance patient care and provide an alternative treatment option for patients suffering from OSA. We believe the following factors offer meaningful benefits for patients, physicians and payors that have the potential to drive broad adoption of our system:

*Patient-centric therapeutic option*

The results of our BLAST OSA trial demonstrated safety and effectiveness of the Genio system for patients suffering from moderate to severe OSA, and the data were sufficient to obtain CE Mark approval from the European Notified Body. These results, which were further supported and reinforced by the results from our BETTER SLEEP and DREAM studies, showed clinically relevant benefits in the following patient-centered outcomes:

● *Attractive safety profile.* The results from the BLAST OSA trial demonstrated that the Genio system was well tolerated with no device-related serious adverse events, or SAEs, reported during the first 6-months of the trial. The results from the DREAM study demonstrated a safety profile in line with other neurostimulation therapy during the first 12-months of the trial (2.6% device related SAEs vs. unilateral HGNS trial that reported a 2.0% rate).

● *Strong therapy compliance*. Our device is designed to be convenient for patients to use once implanted and optimized offering a phone-based application to self-titrate their therapy within preset limits. The BLAST OSA data reported that 91% of patients used the system more than five nights per week over a period of six months following implantation. The DREAM study reported that nightly usage was greater than four hours in more than 70% of nights in 84.3% (59/70) of the participants completing diary entries in the three months preceding the 12-month visit. The device was used over 70% of the nights by 85.9% (61/71) of the participants.

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● *Improved quality of life.* Results from the BLAST OSA trial demonstrated that patients' quality of life significantly improved as assessed using the FOSQ-10 questionnaire, with an increase in mean score by 1.9 units (p-value=0.0157) and a decrease on the Epsworth Sleepiness Scale, or ESS, score, by a mean of 3.3 units (p-value=0.0113). Additionally, the number of sleep partners who reported that their partner did not snore, or snored only softly, increased from 4.2% at baseline to 65.0%. Results from the DREAM trial demonstrated clinically significant improvement (p<0.001) of other secondary metrics: FOSQ-10 increased from 16.0±2.3 to 18.2±1.9. ESS decreased from 9.7±5.6 to 6.2±4.1 and SNORE-25 decreased from 1.6±0.9 to 0.6±0.6. Additionally, data from the DREAM study shows that a participant's snoring score was reduced from 83.5% at baseline to 30.4% at 12 months.

*Bilateral hypoglossal nerve stimulation*

The Genio system was designed to provide bilateral stimulation of the hypoglossal nerve. We believe bilateral stimulation results in a stronger muscle contraction, a more symmetric tongue movement and a wider opening of the airway, which may support better clinical outcomes. We also believe that the bilateral stimulation of the Genio system has the potential to treat moderate to severe OSA in patients with CCC who are currently contraindicated for other HGNS systems.

*Single-incision implant procedure and design* 

The Genio system only has one implantable, low-profile component, which is leadless and battery-free, and only requires a single incision for implantation. Importantly, our system relies on our proprietary duty cycle stimulation algorithm to control the duration, frequency and strength of the neurostimulation. As a result, our system does not require the implantation of a sensing lead to monitor breathing. We believe that the single-incision procedure may support postoperative recovery by limiting the extent of the surgical approach and may be an attractive procedural option for physicians and surgeons.

*External activation chip and battery*

The Genio system's power source is located in the external activation chip, meaning no battery is implanted in the patient. Similarly, the external activation chip also includes the software for each user's personalized therapy and can be updated or upgraded without the need for additional surgical intervention. As a result, we believe the Genio system may reduce the need for additional surgical procedures by enabling battery replacement and system updates to be performed externally, which may impact healthcare resource use and costs.

*Demonstrated improvement in supine OSA symptoms*

The DREAM study was the first large scale, prospective study to mandate study patients to sleep at least an hour in supine position to assess the efficacy of the Genio therapy in that position. The airway is most vulnerable to collapse in the supine position and unilateral HGNS therapies have not demonstrated efficacy in large studies. The DREAM study showed that despite the total supine sleep time approaching 2 hours (114 minutes) at the 12-month polysomnography (PSG), supine AHI was reduced significantly compared to the baseline values (48.9 ± 19.6 to 22.7 ± 19.9 events/h, P < .001). Mean per-participant percent reduction of supine AHI was -55.1 ± 36.5% (median: 66.6%, P < .001) which was comparable to the mean per-participant percent reduction in total AHI was 266.1 ± 28.7% (median:70.8%, P < .001). These results demonstrate that bilateral stimulation may allow for better supine OSA symptom alleviation potentially through incremental airway opening resulting from stimulation.

#### Treating patients with the Genio system
*Patient selection*

Under CE-Mark and FDA approval, the Genio system is indicated for adult patients suffering from moderate to severe OSA with an AHI equal to or greater than 15, but less than 65 events/hour. The Genio system is intended as a second-line therapy for patients who do not tolerate, fail, are ineligible, or refuse current standard of care treatments (such as CPAP therapy).

A variety of considerations are required to assess if a patient is eligible for the Genio system. For instance, patients may only have a body mass index, or BMI, of up to 35kg/m² under CE Mark approval and up to 32kg/m² under FDA approval. Additionally, patients cannot have any medical illness or condition that contraindicates a surgical procedure under general anesthesia or that would prevent the implantation

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*Implantation*

A surgeon implants the implantable stimulator of the Genio system during a single incision procedure under general anesthesia in an outpatient setting. During implantation, the surgeon makes a small curvilinear incision approximately six centimeters in length under the chin to expose the genioglossus muscle and the left and right hypoglossal nerve branches through dissection of multiple muscle layers. The Genio system's unique paddle electrode design allows the surgeon to position the implant over both genioglossus muscles facing both medial left and right branches of the hypoglossal nerve, allowing for bilateral stimulation. During surgery, the surgeon uses the external stimulator to activate and test initial functionality of the implantable stimulator. The activation chip attached to a disposable patch is used within a sterile sleeve to confirm optimal placement of the implant before and after skin closure. After confirmation of optimal anatomical response, the physician completes the implant procedure. Patients are typically discharged the same day and can return home after the completion of the procedure. While patients may experience mild discomfort or swelling at the incision site, this can be managed with over-the-counter pain medications. Recovery typically takes a few days, and many patients can resume normal activities within a week.

*Therapy activation and optimization*

Within approximately eight weeks following implantation, the patient returns to the physician for a follow-up visit where the Genio system is activated. At this visit, the patient is provided appropriate training on how to safely use the different components of the device and how to use the system during therapy. Once they have completed their activation visit, the patient can start using their Genio system during sleep.

The exact level of stimulation varies between patients based on the response of their hypoglossal nerve to the Genio system. Once activated, the patient enters the first phase of the therapy process, during which the device operates using low stimulation parameters that allow the patient to acclimate to the sensations and tongue movement associated with stimulation. Once the patient is acclimated, the second phase of therapy begins. This phase is designed to identify the patient's individual and specific therapeutic levels and patterns of stimulation during wakeful titration and studies performed in a sleep lab. The goal of the wakeful titration is to use nasal endoscopy to identify the optimal tongue contraction characteristics including direction and intensity. Therapy titration is typically completed in one or two visits.

The Genio system delivers stimulation at a programmed rate determined by the physician based on the patient's breathing frequency. To determine the appropriate rate, the patient's breathing frequency is initially analyzed during an in-lab sleep trial. The stimulation pattern is adjusted via the sleep lab application using our proprietary duty cycle algorithm which provides timely, alternative cycles of stimulation with patient-specific targeted therapy. Once the physician determines the desired titration and stimulation pattern, the Genio activation chip is programmed to deliver patient-specific therapy based on those levels and patterns. At the optimal titration setting, the physician aims to keep the upper airway open during sleep to support adequate blood oxygen saturation and sleep continuity without waking the patient.

The figure below illustrates the algorithmic, alternating stimulation cycle used by the Genio system.

![Graphic](nyxh-20251231x20f004.jpg)

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*Daily home stimulation and use*

Once the Genio system is activated, patients use the system at home during sleep to treat the symptoms of their moderate to severe OSA. During the initial post-activation period, system settings are optimized to support therapy effectiveness. We generally recommend that patients return to their physician for periodic follow-ups, including an annual routine visit, during which therapy efficacy can be evaluated and adjustments made as needed.

#### Clinical Results and Studies
We continue to invest in the development of clinical evidence to support the safety and efficacy of the Genio system. Our clinical strategy includes obtaining authorization in our target markets, collecting long-term clinical data for the Genio system and expanding authorized indications to reach a broader patient population, including patients with CCC. We have completed one clinical trial and are conducting three clinical trials globally with the goal of generating reproducible clinical data with the Genio system for patients with moderate to severe OSA.

#### BLAST OSA Trial
*Overview*

The BLAST OSA trial was a prospective, open-label, non-randomized, multicenter, single-arm trial initiated in April 2017 with enrollment completed in February 2018. The objective of this trial was to evaluate and assess the safety, performance and efficacy of the Genio system in adult patients with moderate to severe OSA. The trial measured safety and efficacy endpoints at six months following five months of treatment. The primary safety endpoint was the incidence of device-related SAEs recorded during the trial over a period of six months post implantation. The primary efficacy endpoint was the mean change in the AHI score from baseline to six months post implantation measured by the number of apneas and hypopneas events per hour during an overnight sleep trial. The secondary performance endpoint was the change in the ODI score from baseline to six months post implantation. ODI score was measured by the number of desaturation episodes per hour during an overnight sleep trial. A desaturation period occurs when the patient stops breathing resulting in a decrease in blood oxygen.

Performance measures included changes in the sleep-related quality of life, evaluated by the level of daytime sleepiness using the Epworth Sleepiness Scale, or ESS, and the Functional Outcomes of Sleep Questionnaire, or FOSQ-10, as well as supplementary objective measures evaluated in an in-lab sleep trial, such as therapy response rate. The ESS measures the propensity for daytime sleepiness and the FOSQ-10 questionnaire measures sleep-related quality of life. Therapy response was defined based on the Sher success criteria as a reduction in AHI from baseline to six months of 50% or more, a remaining AHI score at six months of less than 20. The study also evaluated the change in the percentage of time spent at an oxygen desaturation state below 90% (SaO2<90%). Response rate was a percentage of patients passing the Sher success criteria at six months. Sleep partner-reported snoring and nightly usage of the system were also evaluated.

In 2019, the BLAST OSA trial protocol was amended to include a long-term safety follow-up phase. All participants who received the Genio system were eligible to enroll in the long-term follow-up phase of the trial. While the long-term follow-up phase was not initiated, subjects were nevertheless followed up for an additional 36 months before the study was closed out.

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*BLAST OSA Results*

The BLAST OSA results were published in the European Respiratory Journal in October 2019. Screening exclusion criteria included in-lab sleep study test results, AHI that was above 60 or below 20 based on the 2014 American Academy of Sleep Medicine recommended scoring guidelines, or a patient having a non- supine AHI less than 10. Another 18% of patients were excluded from the trial due to CCC. A total of 27 participants underwent the implantation procedure of the Genio system. Of these participants, 63% (17/27) were men with a mean age of 55.9 ± 12.0 years and a mean body mass index of 27.4 ± 3.0 kg/m2. Twenty-two patients completed the protocol, and the trial met all primary, secondary and exploratory endpoints. In the six-month data, the mean individual reduction in AHI events per hour decreased 47.3%. Participants' AHI decreased from 23.7 ± 12.2 to 12.9 ± 10.1, representing a mean change of 10.8 events/ hour (p-value<0.0001). In statistics, a p-value is a number calculated from a statistical test. It provides the probability that a null hypothesis (*e.g.*, there is no treatment effect) is true for the particular set of observations being tested. The smaller the p-value (typically < 0.05), the stronger the evidence that the null hypothesis should be rejected in favor of an alternative hypothesis (*e.g.*, there is a treatment effect greater than a given threshold). A p-value less than 0.05 is said to be statistically significant. It indicates strong evidence against the null hypothesis, as there is less than a 5% probability that the null hypothesis is correct.

*Safety Results*

Four SAEs related to the surgical procedure (but not device-related) were reported in three of the 27 patients implanted during the six-month post-implantation period. These included two participants at the same hospital who developed local infections at the surgical site that resulted in removal of the implanted device. The fourth SAE was impaired swallowing, which led to one day prolongation of implantation-related hospitalization. Two patients were kept in the hospital for overnight observation. All SAEs were successfully resolved. The most frequent procedure-related adverse events, or AEs, that occurred in implanted patients were impairment or painful swallowing (30% of participants), dysarthria, or speech- slurring, (26% of participants), hematoma (19% of participants) and swelling or bruising around the incision site (19% of participants).

No device-related SAEs occurred during the six-month post-implantation period. The majority of device- related AEs were reported as mild and resolved within days. The most frequent device-related AE was a temporary and mild local skin irritation due to use of the disposable patch (30% of participants). This AE was generally resolved with the application of skin lotion to the irritated skin, and there was no discontinuation of therapy within implanted devices. Additional device related AEs that occurred in 11% of the patients included tongue abrasion, tongue fasciculation, discomfort due to electrical stimulation and abnormal scarring. The adverse reaction to stimulation discomfort was typically resolved by reprogramming the stimulation parameters.

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*Trial Performance Results*

Six months post-implantation, the mean individual reduction in AHI events per hour decreased 47.3%. Participants' mean AHI decreased from 23.7±12.2 to 12.9±10.1, representing a mean change of 10.8 events/ hour (p-value<0.0001).

![Graphic](nyxh-20251231x20f005.jpg)

A reduction in the ODI score was demonstrated between baseline and six-month post-implantation, dropping from a mean of 19.1±11.2 to 9.8±6.9, representing a mean change of 9.3 events/hour (p-value<0.001).

Both the propensity for daytime sleepiness, as measured by the Epworth Sleepiness Scale, and sleep-related quality of life, as assessed using FOSQ-10, significantly improved. The ESS decreased from 11.0±5.3 to 8.0±5.4, representing a mean change of 3.3 units (95% CI 0.8-5.7, p-value=0.0113), whereas the FOSQ-10 score increased from 15.3±3.3 to 17.2±3.0, representing a mean change of 1.9 units (95% CI 0.4-3.4, p-value=0.0157). The FOSQ-10 objective is to demonstrate a change in sleep-related quality of life at the 6-month visit compared to baseline. A FOSQ-10 score greater than 17 is considered clinically significant. A score below 8 for the Epworth Sleepiness Scale is considered clinically significant. Finally, the arousal index (measures shift from deep sleep to light sleep) significantly decreased from 28.7±11.5 to 16.0±8.0 (p- value<0.0001), representing a mean change of 12.7 events per hour.

The following chart sets forth the various outcome measures for the intent to treat patient population:

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| | | | | |
|:---|:---|:---|:---|:---|
| <br>**Outcome** | **Baseline**<br>**(n=22)** | **6 months**<br>**(n=22)** | **Mean**<br>**Difference (95% CI)** | <br>**P-value** |
| AHI, events/hour | 23.7 ± (12.2) | 12.9 ± (10.1) | 10.8 ± (14.6 to 7.0) | <0.0001 |
| ODI, events/hour | 19.1 ± (11.2) | 9.8 ± (6.9) | 9.3 ± (13.1 to 5.5) | <0.0001 |
| FOSQ-10 | 15.3 ± (3.3) | 17.2 ± (3.0) | 1.9 ± (0.4 to 3.4) | 0.0157 |
| ESS | 11.0 ± (5.3)\* | 8.0 ± (5.4) | 3.0 ± (5.7 to 0.8) | 0.0113 |
| SaO2<90%, % time | 5.0 ± (6.0) | 2.1 ± (3.0) | 2.9 ± (4.6 to 1.3) | 0.0015 |
| Arousal Index, events per hour | 28.7 ± (11.5) | 16.0 ± (8.0) | 12.7 ± (16.6 to 8.9) | <0.0001 |
| Sleep efficiency (%) | 84.0 ± (10.8) | 87.3 ± (8.9) | 3.2 ± (0-01 to 6.4) | 0.0494 |
| Responder rate (Sher Criteria) at 6-month | 11 patients out of 22 (50%) | 11 patients out of 22 (50%) | NA |  |

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*Legend*

*Data are mean (Standard Deviation) unless otherwise specified. Arousal Index is the number of arousals and awakenings registered during the sleep trial. SaO2 < 90% is the proportion of the night spent at an oxygen saturation below 90%. Sleep efficiency is the ratio of total time spent asleep in a night compared to the total amount of time spent in bed. ESS is the Epworth Sleepiness Scale. FOSQ10 is the 10 — item Functional Outcomes of Sleep Questionnaire. \* means n=21.*

*Other Metrics and Outcomes*

The reported snoring intensity was reduced, with 65.0% of patients' sleep partners reporting no snoring or soft snoring at the six-month post-implantation visit compared to only 4.2% at baseline. Additionally, 91% of patients reported using the Genio system more than five days a week, of whom 77% reported a nightly use of more than five hours per night.

The BLAST OSA trial demonstrated that the Genio system's therapy was well-tolerated, met its performance endpoints, and was associated with high compliance. The trial showed significant reduction of OSA severity and improvement of sleepiness and quality of life, while being well-tolerated.

#### BETTER SLEEP Trial
We are currently conducting the BETTER SLEEP trial, a multicenter, prospective, open-label, two-group clinical trial, designed to assess the long-term safety and performance of the Genio system for the treatment of adult OSA patients with and without CCC over a period of 36 months post- implantation. The BETTER SLEEP trial includes a subgroup of CCC patients, which is a patient population that is contraindicated for unilateral HGNS.

Patients with moderate to severe AHI scores (15 ≤ AHI < 65) and aged between 21 and 75 years were eligible for enrollment if they failed, refused or did not tolerate PAP treatment. Patients with a body mass index above 32 kg/m² were excluded. The trial has been authorized by the Australian and New Zealand regulatory authorities and is being conducted in eight local medical centers.

In the BETTER SLEEP trial, 42 patients were implanted with the Genio system, 18 of which have CCC (or 42.9% of the total implanted population) and 24 who were classified as non-CCC. Three patients in each arm did not complete their six-month polysomnography, and as a result, the analysis was calculated based on 36 patients (15 CCC, 21 non-CCC). Of these 36 patients, there were 23 responders (64%), including nine of the 15 CCC patients (60%) and 14 of the 21 non-CCC patients (67%), at six months.

The primary safety endpoint included the incidence of device-related SAEs from consent to six months post-implant.

Primary and exploratory efficacy endpoints were defined as a mean reduction in AHI (4% oxygen desaturation AHI4) at six months post-implant for the entire cohort and for the CCC subgroup, respectively. Scoring followed the American Academy of Sleep Medicine 2014 acceptable guidelines. Secondary efficacy endpoints included the oxygen desaturation index scored at 4% desaturation (ODI4). Statistical significance was assessed at p<0.05 using paired t-tests.

The overall reduction was statistically significant with an 11-point reduction (p<0.001), with statistically significant reductions of 10 points (p=0.001) in the CCC cohort and 11 points (p<0.001) in the non-CCC cohort. In addition, mean AHI4 reduction exceeded 70% among responders in both CCC and non-CCC cohorts. These results are subject to final review and validation.

With respect to the primary safety endpoint, no device-related SAEs up to six months post-implant were reported by the site investigators. The clinical events committee (CEC) identified two device-related SAEs (device migration, infection). Final review and adjudication of SAEs and AEs have not yet been completed by an independent CEC and as a result the characterization of SAEs or AEs could be subject to change.

We expect to announce additional data with respect to the trial as further analyses are conducted and we seek to publish the full data set from the trial in a peer-reviewed publication. There will be no additional enrollment in the BETTER SLEEP trial. However, we will continue to monitor patients in the evaluable patient population and plan to continue evaluating over the course of three years following implantation.

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In October 2021, we received CE-mark indication approval to treat OSA patients with CCC, based on clinical evidence from the BETTER SLEEP trial.

Additionally, in September 2021, we received breakthrough device designation in the United States for the Genio system from the FDA for the treatment of OSA with CCC, based on the initial clinical evidence from the BETTER SLEEP trial.

#### EliSA Trial
After having obtained certification in Europe for the Genio system in March 2019, we initiated the EliSA post-marketing trial in Europe for the treatment of OSA in adult patients with moderate to severe OSA. The primary objective of this trial is to evaluate the long-term safety and clinical efficacy of the Genio system in adult patients suffering from moderate to severe OSA. The trial is expected to follow patients over a five-year period. EliSA is a multicenter prospective single-arm post market clinical follow-up trial and is expected to enroll at least 110 patients across approximately 25 investigational centers in Europe.

#### Pivotal DREAM Trial
In June 2020, the FDA approved our IDE application, allowing us to commence our pivotal DREAM trial of the Genio system. In June 2022, we announced that the FDA approved the use of the Genio 2.1 system in our DREAM trial. Our DREAM trial is a multicenter, prospective, open-label trial in which each participant who undergoes implantation of the Genio system will be followed for five years post-implantation to assess the safety and efficacy of the system in patients with moderate to severe OSA. We initiated the DREAM trial as an IDE pivotal trial to support an application seeking FDA marketing authorization and ultimately, reimbursement in the United States for bilateral HGNS for the treatment of moderate to severe OSA. The trial enrolled 115 patients who have all been implanted as of the date of this Annual Report, with 12-month effectiveness endpoints and safety objectives. We identified 22 centers for the trial, including 16 in the United States. As of December 2025, 16 sites were active, of which 15 are in the United States.

The primary safety endpoint is incidence of device-related SAEs at 12 - months post implantation. One of the co-primary effectiveness endpoints is the percentage of responders with at least a 50% reduction in AHI with hypopneas associated with a 4% oxyhemoglobin desaturation and a remaining AHI with hypopneas associated with a 4% oxyhemoglobin desaturation less than 20, together with a 25% reduction of ODI between baseline and 12-month visits. Patients with moderate to severe OSA (AHI score between 15 and 65) and aged between 22 and 75 years are eligible for enrollment if they failed, did not tolerate or refused PAP treatment. Patients with a body mass index above 32 kg/m², a CCC observed during a drug induced sleep endoscopy and combined central and mixed AHI above 25% at baseline polysomnography are to be excluded. We presented 12-month data on the first 34 DREAM patients reaching 12-month follow-up as a late-breaking abstract at SLEEP 2023, a joint meeting of the American Academy of Sleep Medicine and the Sleep Research Society, demonstrating a 65% AHI responder rate, a 76% ODI responder rate and safety in line with expectations. These data are preliminary and not conclusive of final success of the DREAM trial.

On March 19, 2024, we announced that our DREAM pivotal trial achieved a statistically significant reduction in the co-primary endpoints of 12-month AHI responder rate, per the Sher criteria, and ODI responder rate, both on an ITT basis. Study participants entered the DREAM trial with a mean AHI of 28.0, mean ODI of 27.0 and mean body mass index of 28.5. At 12-months, 73 subjects were determined to be AHI responders, per the Sher criteria, resulting in an ITT AHI responder rate of 63.5% (p=0.002), and 82 subjects were determined to be ODI responders, resulting in an ODI responder rate of 71.3% (p<0.001). Subjects demonstrated a median 12-month AHI reduction of 70.8%, with similar AHI improvements in supine and non-supine sleeping positions. The safety results for the investigational treatment were favorable, with 11 serious SAEs in ten subjects resulting in an SAE rate of 8.7%. Out of the 11 SAEs, three were device related and there were three explants.

Objective secondary outcomes were assessed in the 89 participants who completed the 12 month PSG. Clinically significant changes were observed in the AHI (-18.3±11.8 events/h, p<0.001), ODI (-17.7±14.6 events/h, p<0.001), and T 90 (-6.9±10.7%, p<0.001). All other secondary metrics also demonstrated clinically significant improvement (p<0.001). FOSQ-10 increased from 16.0±2.3 to 18.2±1.9. ESS decreased from 9.7±5.6 to 6.2±4.1 and SNORE-25 decreased from 1.6±0.9 to 0.6±0.6.

Snoring improved, with those reporting bedpartner leaving the room, very loud and loud snoring reduced from 83.5% at baseline to 30.4% at 12-months. At 12-months, participants' satisfaction scores were reported as extremely satisfied (58.0%), somewhat satisfied (31.8%), somewhat dissatisfied (9.1%), and extremely dissatisfied (1.1%).

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No changes in total sleep time or sleep stage distribution were observed in the exploratory analyses (p> 0.05). Total supine sleep time approached two hours but was reduced compared to baseline (p< 0.001). REM (27.6±24.2 to 8.3±12.2 events/h) and supine AHI (48.9±19.6 to 22.7±19.9 events/h) were reduced at 12 months (p<0.001). Mean per participant percent reduction of total AHI was -66.1±28.7% (median: 70.8%, p<0.001) and mean per participant percent reduction of supine AHI was -55.1 ± 36.5 % (median: 66.6%, p<0.001).

Nightly usage was greater than four hours in more than 70% of nights in 84.3% (59/70) of the participants completing diary entries in the three months preceding the 12-month visit. The device was used over 70% of the nights by 85.9% (61/71) of the participants.

On July 28, 2025, we announced new data from our DREAM pivotal trial regarding device usage and patient satisfaction in the Journal of Clinical Sleep Medicine. The additional findings showed that nightly device usage was greater than four hours in more than 70.0% of nights in 84.3% of participants completing diary entries in the three months preceding the 12-month visit. Overall, the device was used over 70.0% of the nights by 85.9% of the participants. Additionally, 90.0% of the participants expressed satisfaction with the therapy, and data shows that a participant's snoring score was reduced from 83.5% at baseline to 30.4% at 12 months.

***ACCCESS Trial***

In July 2022, we announced that the FDA approved an IDE to enable us to initiate a clinical trial, called ACCCESS, to evaluate the use of the Genio system for the treatment of adult patients with moderate-to-severe OSA with CCC that have failed, did not tolerate, or refused PAP. In the ACCCESS trial, we planned to implant up to 106 subjects with co-primary efficacy endpoints of AHI responder rate, per the Sher criteria, and ODI responder rate, both assessed at twelve months post-implant. However, enrollment of new patients was stopped in the third quarter of 2025, and we anticipate initial readout of the twelve months post-implant data in the third quarter of 2026.

***BREATHE Trial***

On October 3, 2025, as a condition of FDA approval, the Company received authorization to conduct the post-approval study titled BREATHE. The BREATHE study is designed to demonstrate the continued safety and effectiveness of the Genio system in treating subjects diagnosed with moderate to severe OSA who are intolerant to or failed/refused PAP treatments. This study is a multicenter, prospective, single-arm, post-approval study that will enroll and implant 229 patients in up to 25 centers across the United States. First enrollment is expected in the second quarter of 2026, with a two year duration to complete enrollment in the study.

#### Sales and Marketing
We have grown our European commercial team to more than 20 people, including sales representatives, field engineers and marketing professionals, who collectively bring substantial medical device sales, education and clinical experience to support commercialization of the Genio system.

In Germany, Switzerland and the Netherlands, we have successfully obtained reimbursement under a dedicated DRG code for HGNS, in the United Kingdom we are part of the Special Services Device Program, or SSDP, in the United Arabic Emirates we are reimbursed by private insurance using a CPT code and in Kuwait we are reimbursed by the Ministry of Health, or MOH. Each of these reimbursement coverages includes the cost of the Genio system, implant procedure, hospital stay and follow-up care.

In the United States, reimbursement for HGNS is supported through established procedural coding and payer coverage policies. Medicare coverage is generally determined at the local level through Local Coverage Determinations, or LCDs, and related billing and coding guidance issued by regional Medicare Administrative Contractors, with coverage criteria and administrative requirements that can vary by jurisdiction. Commercial coverage is determined by individual private insurers and typically follows technology assessment and clinical evidence review, resulting in variation across plans and geographies. As commercialization progresses, we continue to engage with public and private payers, providers, and relevant stakeholders to support appropriate coverage and patient access, including through ongoing clinical evidence generation, provider education, and health economic and outcomes data development.

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We began our commercial launch of the Genio system in Germany in July 2020. We subsequently expanded commercialization into Switzerland and Spain in 2021, Finland in 2022, Austria in 2023, and England in December 2024. In February, August and December 2025, we began commercialization in the United Arabic Emirates, the United States, and the Netherlands, respectively. At the end of 2025, we had 67 active implant centers outside the United States and 57 activated accounts in the United States. An activated account in the United States is defined as an account in which a surgeon has been trained and the Genio system has been approved through the account's value analysis committee, or VAC, process.

We have established a systematic approach to commercializing the Genio system which centers on active engagement and market development across patients, physicians and hospitals. We market our Genio System to physicians and hospitals where ENTs, sleep doctors and general practitioners see, diagnose and treat patients with OSA. We have developed a methodical marketing strategy to educate and develop the market and a commercial strategy tailored to suit local market needs in order to maximize therapy penetration and patient base expansion.

Our initial strategy is to employ a targeted approach to increase therapy penetration within specific physician practice groups instead of a broad outreach strategy to physicians. Our sales and marketing organization is focused on prioritizing high volume centers that are strategically located and building long-standing relationships with key physicians with strong connectivity to the population of OSA patients indicated for the Genio system. We are focusing our efforts on developing "Centers of Excellence", where we plan to invest in developing the Genio system as the preferred treatment option for appropriate moderate to severe OSA patients in need of an alternative to conventional first-line therapies. Using a direct commercialization model in most of our target countries, we plan to utilize account managers to support the Centers of Excellence to strengthen the referral physician network, guiding new patients to these Centers of Excellence. We expect to gradually scale up in line with market entry and access in the various countries that we are targeting.

Our direct sales representatives and field engineers, which we refer to as our market development team, generally have substantial experience, specifically with patients, physicians and payors in the ENT or neurostimulation space. Our market development team is focused on prioritizing high volume ENT centers, sleep centers, and building long-standing relationships with key physicians such as sleep doctors, ENT and general practitioners who have strong connectivity to the OSA patient population that may be eligible for the Genio system. Additionally, we target cardiac electrophysiologists, cardiologists, cardiovascular surgeons and dentists, which are a second OSA patient referral base for ENT physicians. We support our physicians through all aspects of the patient journey, starting from initial diagnosis through surgical support and post implantation patient follow-up.

We seek to establish long-term partnerships with key opinion leaders and patient associations that are built on mutual trust and oriented towards the needs of our patients and customers. Our marketing organization is focused on building physician awareness through educating common OSA referral sources, general physician and patient education, and targeted KOL development and training. Additionally, we have established and implemented a dedicated direct-to-patient marketing strategy aligned with local regulations in selected countries. Through targeted digital and offline media campaigns, we are raising awareness, engaging and driving patients eligible to the Genio system to our active centers of excellence. We have developed dedicated education and training programs leading to a certification delivered by an approved proctor. These education and training programs offer sleep centers and implanting surgeons excellent training pertaining to the Genio system technology, the latest and most up-to-date insights on the implantation procedure and on therapy optimization as well as on the subject of HGNS science. Additionally, these education and training programs promote a better understanding of OSA, which we believe will result in maximizing outcomes for Genio users, a better understanding of the technology's benefits and risks and increasing confidence in the safety of the technology.

Additionally, we build awareness of the Genio system through digital social networks. The objective of this outreach is to target these patients and make them aware of our education webinars and website, where they can find a wealth of information on OSA and the purpose and benefits of the Genio system, based on our approved labeling. In addition to driving broad awareness and increasing physician and patient education, our marketing team has developed the in-house resources necessary to assist patients and physicians in the process of obtaining reimbursement approval for their procedures.

As of December 31, 2025, we had a commercial organization in the United States of over 50 people, of which 25 were sales representatives or territory managers that are supported by clinical education specialists, pre-authorization and reimbursement support personnel, customer service, marketing resources and leadership.

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#### Research and Development
In addition to our ongoing clinical studies, we are also committed to continuing our research and development efforts related to the Genio system, with an emphasis on improving clinical outcomes, optimizing patient adoption and comfort, increasing access for a greater number of patients and allowing more physicians to perform the procedure. The primary focus of our research and development efforts in the near-term will be the continued technological advancement of the Genio system. Some of these improvements include features aimed at enhancing a physician's ability to monitor patient compliance and therapy efficacy. We continue to enhance our scalable technology platform to potentially enable quick and streamlined release of new features and functionalities through software, firmware and hardware updates as well as therapy enhancement. The design of the external activation chip allows enhancements to the Genio system to be implemented without the need for additional surgical intervention.

In January 2021, we entered into an exclusive license agreement with Vanderbilt University in order to further develop new neurostimulation technologies for the treatment of sleep disordered breathing conditions. We expect that these potential new treatments will focus on stimulating the ansa cervicalis, the efferent fiber of the glossopharyngeal nerve or nerves that innervate the palatoglossus and/or the palatopharyngeus muscle. In parallel with these research and development efforts, we continued to advance the existing Genio platform. We developed a next generation Genio 2.1 system which incorporates an upgraded external activation chip with built in Bluetooth capability and an optional smartphone application that serves as a remote control for patients. These updates were designed to better support patients' use of the system. In June 2022, we announced that the FDA approved the Genio 2.1 system for use in the DREAM trial. In July 2022, we received FDA approval for use of the Genio 2.1 system in the ACCCESS IDE study as well as CE Mark approval for the Genio 2.1 system. In August 2025, the Genio 2.1 system received FDA approval.

Further improvements or a next generation product may also bring additional features or services to the Genio system, potentially opening opportunities to generate revenue from data collected. For example, we expect the future generation of our products to focus on the capability to assess variables related to the patient's sleep quality including monitoring patient respiratory flow, snoring, movement and sleep position as well as the ability for the Genio system to be connected to the cloud. We believe this information may enable us to monitor and better understand the patient's quality of sleep and respiratory status, which we could consider sharing with key stakeholders. For example, we are considering developing solutions designed to enhance patient compliance by letting patients follow up regularly regarding the quality of the treatment received with healthcare connectivity tools. We are also exploring future tools that would provide sleep specialists with access to detailed patient therapy status via a digital care management platform, enabling them, on a remote and potentially reimbursable basis, to assess patient status and adjust Genio system treatment parameters. We believe the Genio system's location close to the airway is optimal for detection and analysis of sleep and respiratory variables.

The next-generation Genio system is expected to involve -among other things- improvements in the user experience and a decreased disposable patch footprint, making the system more environmentally friendly while improving our gross margin profile. For instance, we plan to introduce cloud connectivity, enabling real-time data streaming from the patient. This innovation is expected to support remote therapy monitoring. By integrating these features, we aim to further enhance patient convenience, improve accessibility to care, and create a more sustainable, cost-effective solution. We intend to build a scalable technology platform allowing quick and streamlined release of new features and functionalities through software, firmware, hardware updates and upgrades and therapy enhancement. Through investments in new products and innovation, we expect to be able to increase our gross margin to over 80% once we achieve appropriate scale.

#### Competition
The industry in which we operate is subject to rapid change and is highly sensitive to the introduction of new products and technologies of current or new industry participants. Our primary focus of OSA treatment is as a second line therapy for patients with moderate to severe OSA. If we are not successful in convincing others of the merits of our products or educating them on the use of our products, they may not use our products or use them effectively and we may be unable to increase our sales.

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We consider our primary competition to be other device-based neurostimulation therapies designed to treat patients with moderate to severe OSA. Outside the United States, in addition to Inspire, we also are aware of LivaNova's ImThera device which received CE-Mark approval to market an open-loop neurostimulation device in Europe. In the United States, the Inspire system is currently the only FDA-approved closed-loop neurostimulation device for moderate to severe OSA. In the United States, LivaNova announced in 2021 the initiation of its OSPREY study, an IDE study to support FDA approval and commercialization of the Aura6000 device. LivaNova announced in November 2024 that its OSPREY clinical study met its primary endpoints and further announced in November 2025 that the company expects to launch their therapy in the United States in 2027. We believe other emerging businesses are in the early stages of developing neurostimulation devices.

We also compete with invasive surgical treatment options such as UPPP and MMA, which are primarily used in the treatment of mild to moderate OSA. We do not believe we directly compete with CPAP or other types of positive airway pressure devices because CPAP is typically a first line therapy for patients with OSA.

In 2024, some studies were published demonstrating a positive effect of GLP-1 receptor agonists, such as Mounjaro (Tirzepatide), on Obstructive Sleep Apnea in obese adult patients. These drugs (such as Zepbound - Eli Lilly) are now indicated in the United States for the treatment of Obstructive Sleep Apnea in obese patients. In Europe, the EMA (European Medicines Agency) has determined that Eli Lilly's Mounjaro (Tirzepatide) existing indication for weight management already encompasses it benefits for Obstructive Sleep Apnea in adults with obesity, making a separate indication unnecessary. We expect drugs like Mounjaro (Tirzepatide) to potentially enlarge the pool of patients eligible to hypoglossal nerve stimulation by reducing the BMI of obese patients and allowing them to meet the indication criteria for hypoglossal nerve stimulation. However, we have not experienced the benefit of this impact to date.

We believe that the primary competitive factors in the OSA treatment market are:

● product safety, reliability and durability;

● company and brand recognition;

● ease of implantation and procedure time;

● quality of clinical data;

● adoption by patients, physicians and sleep centers;

● adequate reimbursement for our device;

● procedure costs to patients;

● product ease of use and patient comfort;

● sales force expansion, experience and access;

● product availability, support and service;

● manufacturing and supply chain;

● technological innovation and product enhancements; and

● intellectual property portfolio.

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In addition, our competitors may have greater financial resources or more established distribution networks than we do or may be acquired by enterprises that have more established distribution networks than we do. Our competitors may also develop and patent processes or products earlier than we can or obtain domestic or international regulatory clearances or approvals for competing products more rapidly than we can, which could impair our ability to develop and commercialize similar products. We also compete with our competitors in acquiring technologies and technology licenses complementary to our products or advantageous to our business. We also compete with other medical technology companies to recruit and retain qualified sales, training and other personnel.

#### Manufacturing and Supply
We rely on third-parties to manufacture and supply all the components of the Genio system to our specifications. Most components are supplied by single-source suppliers. The raw materials used by our suppliers are purchased in the open market. We continue to look for additional or replacement suppliers for the currently single-source components and we plan to maintain a sufficient level of inventory of such components to enable continued production for a limited period, such as during a supplier transition phase.

For the manufacturing of the Genio system's implantable stimulator used for clinical and European commercial activities, subassemblies and other components are purchased from external suppliers with the final assembly being done in our manufacturing facilities in Belgium. For the manufacturing of the Genio system's implantable stimulator used for U.S. commercial activities, we work together with a U.S. third party manufacturer. For the external parts of the Genio system, we have fully outsourced the manufacturing of those products.

In January 2026, we announced an investment in further expanding our manufacturing capacity to support worldwide growth by entering a nine-year lease of 2,000 square meters for a state of the art cleanroom. We expect this facility to be fully operational in 2027.

#### Collaboration and License Agreements

#### Cochlear Collaboration Agreement
We and Cochlear Limited, or Cochlear, entered into a collaboration agreement, dated November 2018, under which we and Cochlear agreed to collaborate to further develop and progress commercialization of implantable treatments for sleep disordered breathing conditions. Cochlear has significant expertise in the development of implantable devices. The specific contributions and services to be used, applied and provided by both parties were detailed in several "*Statements of Work*", with an initial Statement of Work agreed upon by us and Cochlear in November 2018, and further Statements of Work agreed between June 2020 and January 2023. Pursuant to the various Statements of Work, Cochlear evaluated various packaging technologies to support us in the assessment of encapsulation technologies for the implantable stimulator, and worked with us in developing and enhancing the next generation implantable stimulator, and provided support in a transfer project to a U.S. third party manufacturer. As all work under the Statements of Work has been completed and parties do not currently have the intention to enter into additional Statements of Work, the collaboration agreement can be considered as ended.

There are currently no IP licenses granted by Cochlear or by us to the other party.

#### Man & Science Agreement
We, Man & Science SA, Cephalix SA, Glucobel SA and Surgical Electronics SA, among others, have entered into a multiparty agreement regarding their respective ownership and licensing rights in relation to multiple inventions, including but not limited to inventions generally related to implantable, flexible neurostimulators and inventions for specific medical indications including sleep disordered breathing, head pain, glucose monitoring, hypertension and other indications. This agreement provides that (i) we fully own all rights in relation to the inventions specifically related to the sleep disordered breathing field, which we believe includes sleep disordered breathing conditions such as sleep apnea and snoring, and comorbidities of these conditions and (ii) Man & Science SA is the owner of the generic inventions and granted a fully paid-up, exclusive and worldwide, license with respect to these inventions to several parties, including us in the field of sleep disordered breathing. Pursuant to the terms of the agreement, no party may terminate the licenses.

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In June 2016, we, Cephalix SA, Surgical Electronics SA, and Man & Science SA entered into a confirmatory addendum, aiming to confirm that (i) we fully own all rights in relation to the inventions specifically related to the sleep disordered breathing field as further detailed in the agreement, (ii) Man & Science SA granted an exclusive, worldwide, fully paid-up, royalty free and transferable license to us covering certain patents in the sleep disordered breathing field, and (iii) we granted an exclusive, fully paid-up, royalty free, transferable license to use certain of those patents outside the sleep disordered breathing field, namely to Cephalix SA in the head pain field, Surgical Electronics SA in the hypertension field and Man & Science SA outside the head pain field and the hypertension field.

In February 2020, we entered into a clarification of the Confirmatory Addendum, or Clarification, with Man & Science SA. The Clarification confirms that the license granted to us by Man & Science SA under the agreement and the Addendum are irrevocable, transferable, fully paid up, royalty-free and include the right to grant sublicenses in the sleep disordered breathing field, which are retroactive as from the filing date of the oldest of the patents and patent applications and will continue in effect until the last to expire patent, which is expected to occur in 2032 (excluding any potential patent term extension). We have no current or future financial obligation to Man & Science SA pursuant to the agreement.

Effective October 1, 2024, the Company entered into a collaboration agreement with Man & Science SA to develop a miniaturized injectable neuromodulation device. Man & Science SA is to lead the development of this innovative device and Nyxoah is to provide its expertise and knowhow in the field of R&D, Clinical and Regulatory for a period of two years. Nyxoah is to receive from Man & Science SA an exclusive, royalty-free, perpetual, worldwide, transferable and sub-licensable license to use, develop and commercialize the developed technology in the field of obstructive sleep apnea.

#### Intellectual Property
Our intellectual property and the rights underlying the same are valuable and important in the medical device and health tech industry in which we operate. Our success depends, in part, on our ability to obtain and maintain intellectual property protection for our product candidates, to defend and enforce our intellectual property rights, to preserve the confidentiality of our know-how and proprietary information, and to operate without infringing upon the proprietary rights of others. We seek to protect our products and product candidates by, among other methods, filing U.S. and foreign patent applications related to our proprietary technology, inventions and improvements that are important to the development of our business. We rely heavily on our patent and design portfolio to maintain competitive technological advantage, as well as on our trademarks that support our brand identity.

We have implemented an intellectual property protection policy with the objective of obtaining protection for key aspects of the technology embodied in the Genio system and certain methods of use.

We may, from time to time, file patent applications for inventions that may be of importance to our future business. We may license or acquire rights to patents, patent applications, or other intellectual property owned by third parties, academic partners or commercial companies which are of interest to us. Further, we may decide, from time to time, to license our intellectual property to other parties, for example, in exchange for cash, marketing collaboration, or other valuable consideration to us.

We continuously review our development activities to assess the novelty and patentability of new intellectual property being developed. In addition to patents, we also rely on a combination of trade secrets, design rights, copyright laws, non-disclosure agreements and other contractual provisions and technical measures that help us maintain and develop our competitive position with respect to intellectual property. Despite our efforts to protect our intellectual property rights, third parties might invalidate, engineer around these or challenge our rights in court or patent offices.

As of December 31, 2025, we have 337 granted patents and pending patent applications comprised of 57 granted U.S. patents, eight pending U.S. patent applications, 244 patents granted in jurisdictions outside the United States (including Australia, Canada, China, Europe, Hong Kong, Israel, and Japan) and 28 pending patent applications in jurisdictions outside the United States (including Australia, Canada, China, Europe, Hong Kong, and Japan). The exclusivity terms of our patents depend upon the laws of the countries in which they are obtained. In the countries in which we currently file, the patent term is 20 years from the earliest date of filing of a non-provisional patent application. Current issued patents and patent applications covering our Genio system will expire on dates ranging from 2032 to 2034, if the applications are issued.

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In addition to the patent portfolio owned by us, we hold exclusive licenses granting us a fully paid-up, transferrable and sub-licensable, worldwide, irrevocable license and royalty free in the field of sleep disordered breathing in relation to multiple inventions, including but not limited to inventions generally related to implantable flexible neuro-stimulators. Such licenses were granted to us by Man & Science SA (a company held and governed by Robert Taub, TOGETHER Partnership, Jürgen Hambrecht and Noshaq SA).

We also hold an exclusive worldwide license from Vanderbilt University, to develop, use, grant sublicense and commercialize products, with a different mechanism of action than the Genio system, in the field of sleep disordered breathing conditions and comorbidities of such conditions. We will also work together with Vanderbilt University to continue prosecution of patent applications made by Vanderbilt. Under the agreement, we paid to Vanderbilt an upfront license issue fee of approximately $650,000. We may be required to pay earned royalties in the mid-single digits on net sales of licensed products that are covered by the patent rights owned by Vanderbilt. After the second anniversary of the agreement, we may terminate the obligation to pay further earned royalties to Vanderbilt on net sales of licensed products in exchange for a one-time royalty buyout payment. A first annual royalty payment of $250,000 was due in relation to 2024, and a second annual royalty payment of $250,000 was due in relation to 2025. We may be required to make additional annual royalty payments to Vanderbilt of up to $500,000 in relation to 2026 and 2027, and up to $1,000,000 in relation to 2028 and each year thereafter, which are creditable against the earned royalties owed to Vanderbilt for the same calendar year. Additionally, Vanderbilt may be entitled to milestone payments of up to an aggregate of $15,750,000 in connection with patent issuance, clinical studies, regulatory approvals and net sales milestones, with a minimum of $1,000,000 due in 2025 and $1,000,000 due in 2026. We may also be required to pay Vanderbilt a low to mid double-digit percentage, not to exceed 40% of any non-royalty sublicensing revenue we receive. The Vanderbilt Agreement, including the royalty obligations thereunder, will continue on a licensed product-by- licensed product and country-by-country basis until the expiration date of the last-to expire licensed patent in each country. Either we or Vanderbilt may terminate the Vanderbilt Agreement in connection with the other party's insolvency. Vanderbilt may also terminate the Vanderbilt Agreement in the event we fail to make a payment to Vanderbilt, breach or default our diligence obligations or breach or default on any other material term, and if we fail to make such payment or cure such breach or default within 60 days of written notice from Vanderbilt. We may terminate the agreement by providing 120 days' advance notice to Vanderbilt.

With respect to trademarks, we use our corporate name, Nyxoah, and associated logo as well as the tagline, in creating awareness of our expertise and in marketing our Genio system technology. We use the trademark Genio to identify our Genio system. We have obtained registration for the Nyxoah name and the Genio trademark in seven jurisdictions around the globe.

#### Government Regulation
Governmental authorities in the United States, at the federal, state and local level, and in other countries and jurisdictions, including the European Union, extensively regulate, among other things, the research, development, testing, manufacture, quality control, certification, authorization, approval, packaging, storage, recordkeeping, labeling, advertising, promotion, distribution, marketing, post-approval monitoring and reporting, and import and export of medical device products. As a medical device manufacturer, our operations are subject to such laws and regulations in the jurisdictions in which we or our research and development partners or affiliates do business.

The processes for obtaining marketing approvals in the United States and in other countries and jurisdictions, along with subsequent compliance with applicable statutes and regulations, as well as policies and rules established by regulatory authorities, require the expenditure of substantial time and financial resources. In addition, the laws and regulations governing our business and interpretations of those laws and regulations and are subject to frequent change, and we must, therefore, devote significant resources to monitoring developments in legislation, enforcement, and regulation in such areas. Our ability to operate profitably will depend in part upon our ability, and that of our research and development partners and affiliates, to operate in compliance with applicable laws and regulations. As the applicable laws and regulations change, we are likely to make conforming modifications in our business processes from time to time. We cannot provide assurance that a review of our business by courts or regulatory authorities will not result in determinations that could adversely affect our operations or that the regulatory environment will not change in a way that restricts our operations.

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#### Regulatory Landscape in the European Union
The EU has adopted specific directives and subsequently regulations governing the design, manufacture, clinical investigations, labeling, conformity assessment, post-market surveillance and vigilance reporting for medical devices. EU directives, which had to be implemented into the national laws of the EU member states, led to certain variations between national laws of the different member states. Regulations are directly applicable in all EU member states from their effective applicability date and are intended to eliminate differences in the regulation of medical device requirements among EU member states. The EU rules listed below are generally applicable in the EEA. Other countries, such as Switzerland, have entered into Mutual Recognition Agreements and allow the marketing of medical devices that meet EU requirements.

Prior to May 26, 2021, all medical devices placed on the EU market had to meet the relevant essential requirements laid down in Council Directive 93/42/EEC, or the Medical Devices Directive (MDD) and the Council Directive 90/385/EEC, or the Active Implantable Medical Devices Directive (AIMDD). Active Implantable Medical Devices, or AIMDs, are defined as medical devices that rely on a source of electrical energy or any source of power other than that generated by the body, which are totally or partially introduced, either surgically or medically, into the human body and intended to remain after the procedure.

On May 26, 2021, Regulation (EU) 2017/745 of 5 April 2017 on medical devices, or the Medical Device Regulation (MDR), became effective, repealing and replacing the MDD and the AIMDD. The MDR is directly applicable in all EU member states. The MDR changed several aspects of the regulatory framework for medical device marketing in Europe in order to increase regulatory oversight of all medical devices marketed in the EU (which, in turn, increased the costs, time and requirements to place innovative or high-risk medical devices on the European market). The MDR among other things:

● strengthens the rules on placing devices on the market and reinforces surveillance once they are available;

● establishes explicit provisions on manufacturers' responsibilities for the follow-up of the quality, performance and safety of devices placed on the market;

● improves the traceability of medical devices throughout the supply chain to the end-user or patient through a unique identification number;

● sets up a central database to provide patients, healthcare professionals and the public with comprehensive information on products available in the European Union, or EU; and

● strengthens the rules for the assessment of certain high-risk devices, which may have to undergo an additional check by experts before they are placed on the market.

An overarching requirement under the MDR is that any device must be designed and manufactured in such a way that it will not compromise the clinical condition or safety of patients, or the safety and health of users and others. In addition, the device must meet the performance specifications intended by the manufacturer and be designed, manufactured and packaged in a suitable manner. To that effect, the European Commission has adopted certain common specifications and has recognized various standards applicable to medical devices. These include standards governing common requirements, such as sterilization and safety of medical electrical equipment and product standards for certain types of medical devices. There are also harmonized standards relating to design and manufacture. A harmonized standard is a European standard developed by a recognized European Standards Organization. While not mandatory, compliance with harmonized standards is a way for manufacturers to demonstrate that products comply with relevant EU legislation.

To demonstrate compliance with the General Safety and Performance Requirements, or GSPRs, laid down in the MDR, medical device manufacturers must undergo a conformity assessment procedure, which varies according to the type of medical device and its (risk) classification. Conformity assessment procedures require an assessment of the technical documentation, including the device description, the design stages, the manufacturing process, available clinical evidence, literature data for the product, and post-market experience in respect of similar products already marketed.

For Class I non-sterile, non-measuring and non-reusable surgical devices, a manufacturer can self-declare the conformity of its products with the GSPRs. For all other classes of medical devices, a conformity assessment procedure requires the involvement of a Notified Body. In the case of Class I devices that are sterile, measuring or reusable surgical devices (i.e., Class Is, Im or Ir), such involvement is limited to the relevant aspects of sterility, metrology or reuse.

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To that effect, where required, manufacturers of medical devices must make an application to a Notified Body. Notified Bodies are independent organizations designated by EU member states to assess the conformity of devices before being placed on the market. A Notified Body would typically audit and examine a product's technical documentation as well as the manufacturers' Quality Management System, which is most commonly established in accordance with the ISO 13485 standard related to Medical Devices Quality Management Systems. If satisfied that the medical device conforms to the relevant GSPRs, the Notified Body issues the applicable conformity certificate, which the manufacturer uses as a basis for its own declaration of conformity. The manufacturer may then apply the CE-Mark to the device, allowing the device to be legally marketed throughout the EU.

Notified Body certificates of conformity are valid for a fixed duration, which shall not exceed five years.

Throughout the term of the certificate, the manufacturer will be subject to periodic surveillance audits to verify continued compliance with the applicable requirements. In addition, the Notified Body will conduct a recertification audit prior to renewal of the relevant certificate(s).

As a general rule, demonstration of conformity of medical devices with the GSPRs must be based, among other things, on the evaluation of clinical data supporting the safety and performance of the products during normal conditions of use. Specifically, a manufacturer must demonstrate that the device achieves its intended performance during normal conditions of use, that the known and foreseeable risks, and any adverse events, are minimized and acceptable when weighed against the benefits of its intended performance, and that any claims made about the performance and safety of the device are supported by suitable evidence.

In order to demonstrate safety and effectiveness for their medical devices, manufacturers must plan, conduct and document a clinical evaluation in accordance with Article 61 and Annex XIV of the MDR. Clinical investigations conducted in accordance with the requirements of Annex XV to the MDR may be required in order to generate the necessary clinical data and are required for Class III and implantable devices, unless an exemption applies. Clinical investigations for medical devices usually require the approval of ethics committees and approval by the national regulatory authorities. Both regulators and ethics committees also require the submission of periodic safety reports during a study and may request a copy of the final study report.

Once the product has been placed on the market in the EU, the manufacturer must comply with the vigilance reporting requirements under the MDR. In accordance with these vigilance reporting requirements, serious incidents must be reported to the relevant authorities of the EU member states, and manufacturers are required to take Field Safety Corrective Actions, or FSCAs, where necessary, to reduce a risk of death or serious deterioration in the state of health associated with the use of a medical device that is already placed on the market. A serious incident is defined as any malfunction or deterioration in the characteristics or performance of a device made available on the market, including use-error due to ergonomic features, as well as any inadequacy in the information supplied by the manufacturer and any undesirable side-effect that directly or indirectly led, might have led or might lead to death, temporary or permanent serious deterioration of health state, or a serious public health threat.

An FSCA can include the withdrawal of the device from the market, or a recall thereof. FSCAs must be communicated by the manufacturer or its legal representative to the users of the device through Field Safety Notices. Furthermore, the manufacturer must report any statistically significant increase in the frequency or severity of incidents that are not serious incidents or that are expected undesirable side-effects where such increase could have a significant impact on the benefit-risk analysis and which have led, or may lead, to risks to the health or safety of patients, users or other persons that are unacceptable when weighed against the intended benefits. The significant increase shall be established in comparison to the foreseeable frequency or severity of such incidents in respect of the device, or category or group of devices, in question during a specific period as specified in the technical documentation and product information.

The advertising and promotion of medical devices is subject to certain general principles set forth in EU directives. Directive 2006/114/EC concerning misleading and comparative advertising and Directive 2005/29/EC on unfair commercial practices. While the aforementioned directives are not specific to the advertising of medical devices, the provisions of national law transposing them must also be complied with and contain general rules, for example requiring that advertisements are evidenced, balanced and not misleading. Specific requirements are defined at national level. EU member state laws related to the advertising and promotion of medical devices, which vary between jurisdictions, may limit or restrict the advertising and promotion of products to the general public and may impose limitations on promotional activities with healthcare professionals.

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Many EU member states have adopted specific anti-gift statutes that further limit commercial practices for medical devices, in particular vis-à-vis healthcare professionals and organizations. Additionally, there has been a recent trend of increased regulation of payments and transfers of value provided to healthcare professionals or entities. In addition, many EU member states have adopted national "Sunshine Acts" which impose reporting and transparency requirements (often on an annual basis), similar to the requirements in the United States, on medical device manufacturers. Certain countries also mandate implementation of commercial compliance programs.

Devices lawfully placed on the market pursuant to the MDD and the AIMDD prior to May 26, 2021 could initially continue to be made available on the market or put into service until May 26, 2025. Nevertheless, the European Parliament very recently adopted legislation to extend this transitional period to give manufacturers more time to switch from the previously applicable provisions to the new certification requirements for medical devices as laid down by the MDR. For high risk, class III and class IIb implantable devices the transitional period is extended until December 31, 2027. For medium and low risk, class IIb devices and class IIa, Im, Is and Ir devices the transition period is extended until December 31, 2028.

On December 16, 2025, the European Commission published a proposal for a regulation amending, amongst others, the MDR with a view to simplifying and reducing the burden of the rules on medical devices. The proposal has as objective to simplify European rules for medical devices, to support the digitalization of procedures, and to offer a modern, adaptive framework so that companies can respond to changing market conditions and patient needs. We will monitor the discussions and potential adoption of this proposal going forward.

We obtained CE-Mark approval for the Genio system under the AIMDD in March 2019 and for the Genio 2.1 system under the MDR in July 2022. DEKRA Certification B.V., a notified body designated under the MDR and applicable EU medical device legislation, assessed our quality system and the relevant technical documentation and issued the applicable EC certificates supporting CE marking of the Genio system and Genio 2.1 system.

In January 2024, the Company entered into an agreement with DEKRA Certification B.V. under which the validity of the Genio system EC certificate issued under the AIMDD was extended until December 31, 2027. This extension allows the Genio system to continue to be commercially sold and made available in the European Union in accordance with applicable MDR transitional provisions.

Our site in Mont-Saint-Guibert is certified in accordance with ISO 13485:2016 and serves as the legal manufacturer for all our products. Our Milmort manufacturing facility is also certified in accordance with ISO 13485:2016. CE marking and ISO certification are subject to ongoing surveillance and periodic reassessment by the applicable notified body and certification authorities. We maintain processes designed to support ongoing compliance with applicable regulatory requirements and relevant harmonized standards.

*United Kingdom Regulatory Framework and Operational Impacts Post-Brexit*

The United Kingdom left the European Union on January 31, 2020 (commonly referred to as "Brexit"), with a transitional period that expired on December 31, 2020. The United Kingdom and the European Union entered into a trade agreement known as the Trade and Cooperation Agreement, or TCA, which came into effect on January 1, 2021. The TCA does not specifically refer to medical devices. However, as a result of Brexit, the MDR will not be implemented in the UK (except in Northern Ireland), and previous legislation that mirrored the MDR in the UK law has been revoked. The regulatory regime for medical devices in the UK will continue to be based on the requirements derived from previous EU legislation, and the UK may choose to retain regulatory flexibility or align with the MDR going forward. CE-Markings will continue to be recognized in the UK, and certificates issued by EU recognized Notified Bodies will be valid in the UK, until the earlier of June 30, 2028 or the expiration of the certificate for devices compliant with the MDD or AIMDD or until June 30, 2030 for devices compliant with the MDR. For medical devices placed on the UK market after this period, the UK Conformity Assessed, or UKCA, marking will be mandatory. In contrast, UKCA marking and certificates issued by UK Notified Bodies will not be recognized on the EU market. The TCA does provide for cooperation and exchange of information in the area of product safety and compliance, including market surveillance, enforcement activities and measures, standardization related activities, exchanges of officials, and coordinated product recalls (or other similar actions). For medical devices that are locally manufactured but use components from other countries, the "rules of origin" criteria will need to be reviewed. Depending on which countries products will ultimately be sold in, manufacturers may start seeking alternative sources for components if this would allow them to benefit from no tariffs. In March 2023, the UK government and the European Commission reached agreement on a regulatory framework, the Windsor Framework, governing the marketing of medical products in Northern Ireland. Under the Windsor Framework, which became effective on January 1, 2025, the MDR and CE-mark requirements will continue to apply to medical devices marketed in Northern Ireland. It remains to be seen how the UK rules will impact regulatory requirements for our product candidates and our product in the United Kingdom. We continue to evaluate the potential impacts on our business of the new Trade and Cooperation Agreement.

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Such outcomes could make it more difficult and expensive for us to do business in Europe, complicate our clinical, manufacturing and regulatory strategies and impair our ability to obtain and maintain regulatory approval for, and, if approved, commercialize, our products and product candidates in Europe.

#### Regulatory Landscape in the United States
Medical devices are strictly regulated by the FDA in the United States. Under the Federal Food, Drug, and Cosmetic Act, or FDCA, a medical device is defined as "an instrument, apparatus, implement, machine, contrivance, implant, in vitro reagent, or other similar or related article, including a component, part or accessory which is: recognized in the official National Formulary, or the United States Pharmacopoeia, or any supplement to them, intended for use in the diagnosis of disease or other conditions, or in the cure, mitigation, treatment, or prevention of disease, in man or other animals; or intended to affect the structure or any function of the body of man or other animals, and which does not achieve its primary intended purposes through chemical action within or on the body of man or other animals and which is not dependent upon being metabolized for the achievement of any of its primary intended purposes." This definition provides a clear distinction between a medical device and other FDA regulated products such as drugs. If the primary intended use of a medical product is achieved through chemical action or by being metabolized by the body, the product is usually a drug or biologic. If not, it is generally a medical device.

The Genio system is regulated by the FDA as a medical device under the FDCA, as implemented and enforced by the FDA. The FDA regulates, among other things, the development, testing, manufacturing, labeling, packaging, storage, installation, servicing, advertising, promotion, marketing, distribution, import, export, and market surveillance of our medical devices. In August 2025, the FDA granted approval of our PMA application for the Genio system, allowing us to commercialize the system in the United States.

*FDA Authorization of Medical Devices - Regulatory Requirements*

Under the FDCA, medical devices are classified into one of three classes - Class I, Class II or Class III - depending on the degree of risk associated with each medical device and the extent of controls needed to provide reasonable assurance of safety and effectiveness. Classification of a device is important because it determines, among other things, the necessity and type of FDA review required prior to marketing the device.

Before being introduced into the U.S. market, each medical device must obtain marketing authorization from the FDA through the applicable regulatory pathway, which may include the premarket notification, or 510(k), process, the De Novo classification process or the premarket approval, or PMA, process, unless the device is classified as Class I or otherwise qualifies for an exemption from premarket review.

*General Controls*

All device manufacturers are also subject to the quality management system rules described in the FDA's Quality Management System Regulation, or QMSR, which includes both design control and other current good manufacturing practice requirements, including rules relating to purchasing controls, document controls, production and process controls, labeling and packaging controls, control of nonconforming product, complaint handling, corrective and preventative actions, storage, handling, distribution, and servicing. The QMSR became effective as of February 2, 2026 and was adopted for the purpose of harmonizing the FDA's medical device quality system requirements with ISO 13485:2016.

*Class I Devices*

Class I devices are those for which reasonable assurance of safety and effectiveness can be maintained through adherence to general controls, which include compliance with the applicable portions of the FDA's regulations requiring facility registration and product listing, reporting of adverse medical events and any recalls, corrections or removals, and appropriate, truthful and non-misleading labeling, advertising, and promotional materials. The Class I designation also applies to devices for which there is insufficient information to determine that general controls are sufficient to provide reasonable assurance of the safety and effectiveness of the device or to establish special controls to provide such assurance, but that are not life-supporting or life-sustaining or for a use which is of substantial importance in preventing impairment of human health, and that do not present a potential, unreasonable risk of illness or injury.

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*Special Controls and Premarket Notification*

Class II devices are those for which general controls alone are insufficient to provide reasonable assurance of safety and effectiveness and there is sufficient information to establish "special controls." These special controls can include performance standards, post-market surveillance requirements, patient registries and FDA guidance documents describing device-specific special controls. Most Class II devices require a premarket notification prior to commercialization in the United States; however, the FDA has the authority to exempt Class II devices from the premarket notification requirement under certain circumstances. As a result, manufacturers of most Class II devices must submit premarket notifications to the FDA under Section 510(k) of the FDCA (21 U.S.C. § 360(k)) in order to obtain the necessary authorization to market or commercially distribute such devices. To obtain 510(k) clearance, manufacturers must submit to the FDA adequate information demonstrating that the proposed device is "substantially equivalent" to a "predicate device" that is already on the market. A predicate device is a legally marketed device that is not subject to PMA, meaning, (i) a device that was legally marketed prior to May 28, 1976, or preamendments device, and for which a PMA is not required, (ii) a device that has been reclassified from Class III to Class II or I, or (iii) a device that was found substantially equivalent through the 510(k) process.

Following receipt of a premarket notification for a device, the FDA conducts an administrative review to determine whether the submission is sufficiently complete to permit a substantive review. According to the most recent medical device user fee goals, the FDA will attempt to issue a decision within 90 days of receipt on 95% of all 510(k) submissions accepted for review. However, the FDA may stop the review clock for up to 180 days to request that the applicant respond to the agency's requests for additional information about the proposed device. If the FDA agrees that the device is substantially equivalent to the predicate device identified by the applicant in a premarket notification submission, the agency will grant 510(k) clearance for the new device, permitting the applicant to commercialize the device. Premarket notifications are subject to user fees, unless a specific exemption applies.

After a medical device receives 510(k) clearance, any modification that could significantly affect the device's safety or effectiveness, or that would constitute a major change in its intended use, requires a new 510(k) submission or could require a PMA application. The FDA requires each manufacturer to make the determination of whether a device modification requires a new 510(k) or PMA in the first instance, but the FDA may review any such decision. If the FDA disagrees with a manufacturer's decision not to seek a new 510(k) clearance or PMA for a particular change, the FDA may retroactively require the manufacturer to submit a 510(k) or PMA application. The FDA may also require the manufacturer to cease its marketing activities for the modified device in the United States and/or recall the device until the appropriate marketing authorization for the modification is obtained.

*Premarket Approval and De Novo Classification*

If there is no adequate predicate to which a manufacturer can compare its proposed device, the proposed device is automatically classified as a Class III device. In such cases, a device manufacturer must then fulfill the more rigorous PMA requirements or can request a risk-based classification determination for its device in accordance with the De Novo classification process.

Devices that are intended to be life sustaining or life supporting, devices that are implantable, devices that present a potential unreasonable risk of harm or are of substantial importance in preventing impairment of health, and devices that are not substantially equivalent to a predicate device and for which safety and effectiveness cannot be assured solely by the general controls and special controls are placed in Class III. Such devices generally require FDA approval through the PMA process, unless the device is a preamendments device not yet subject to a regulation requiring premarket approval.

The PMA process is more demanding than the 510(k) process. For a PMA, the manufacturer must provide valid scientific evidence, which typically includes extensive preclinical testing and, in most cases, data from one or more clinical studies, to demonstrate that the device is safe and effective for its proposed indication. The PMA application must also contain a full description of the device and its components, a full description of the methods, facilities and controls used for manufacturing, and proposed labeling. Following receipt of a PMA application, the FDA determines whether the application is sufficiently complete to permit a substantive review. If the FDA accepts the application for review, it has 180 days under the FDCA to complete its review and determine whether the proposed device can be approved for commercialization, although in practice, PMA application reviews often take significantly longer, and it can take up to several years for the FDA to issue a final decision. Before approving a PMA, the FDA generally also performs an on-site Pre-Approval Inspection (PAI) of manufacturing facilities for the product to ensure compliance with the quality system requirements.

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The FDA may refer any PMA application, including those for novel device candidates or device candidates that present difficult questions of safety or efficacy, to an advisory committee for review. Typically, an advisory committee is a panel of independent experts, including clinicians and other scientific experts, that reviews, evaluates and provides a recommendation as to whether the application should be approved and, if so, under what conditions. The FDA is not bound by the recommendation of an advisory committee, but it considers such recommendations when making final decisions on approval.

If the FDA's evaluation of the PMA application and inspection of the manufacturing facility is favorable, the FDA may issue an approval order authorizing commercial marketing of the device, or an "approvable letter," which usually contains a number of conditions that must be met in order to secure final approval of the PMA application. When and if those conditions have been met to the satisfaction of the FDA, the agency will issue an approval order, subject to the conditions of approval and the limitations established in the approval order. If the FDA's evaluation of a PMA application or manufacturing facility is not favorable, the FDA will deny approval or issue a "not approvable letter." The FDA may also determine that additional studies are necessary, in which case final approval may be delayed for several months or years while such additional studies are conducted and data is submitted in an amendment to the PMA application. The PMA process can be expensive, uncertain and lengthy, and each PMA submission is subject to a substantial user fee unless a specific exemption applies. PMA application approval may also be granted with post-approval requirements such as the need for additional patient follow-up or requirements to conduct additional clinical trials.

New PMA applications or PMA supplements may be required for any modifications to the manufacturing process, labeling, device specifications, materials or design of a device that is approved through the PMA process. PMA supplements often require submission of the same type of information as an initial PMA application, except that the supplements are limited to information needed to support any changes from the device covered by the approved PMA application and may or may not require as extensive clinical data or the convening of an advisory committee.

The De Novo classification process allows a manufacturer whose novel device is automatically classified into Class III to request that the FDA classify such device as Class I or Class II based on evidence that the device in fact presents low or moderate risk, instead of following the typical Class III device pathway requiring the submission and approval of a PMA application. Under the Food and Drug Administration Safety and Innovation Act of 2012, or FDASIA, the FDA is required to classify a device within 120 days following receipt of the De Novo classification request from an applicant; however, the process may take significantly longer. For example, the most recent FDA user fee goals state that the agency will attempt to issue a decision within 150 days of receipt on 70% of all De Novo classification requests received during each fiscal year. If the manufacturer seeks reclassification into Class II, the classification request must include a draft proposal for special controls that are necessary to provide a reasonable assurance of the safety and effectiveness of the medical device. If FDA grants the De Novo request, the device may be legally commercialized in the United States. However, the FDA may reject the classification request if the agency identifies a suitable legally marketed predicate device that provides a reasonable basis for review of substantial equivalence or determines that the device is not low to moderate risk or that general controls would be inadequate to control the risks and adequate special controls cannot be developed. De Novo classification requests are subject to user fees, unless a specific exemption applies.

*Device Clinical Studies*

Clinical studies are almost always required to support PMA applications and are sometimes required to support 510(k) and De Novo classification submissions. All clinical investigations of devices to determine safety and effectiveness must be conducted in accordance with, among other laws and regulations governing clinical trials and human subject protections, the FDA's good clinical practice, or GCP, regulations, including the investigational device exemption, or IDE, regulations that govern investigational device labeling, prohibit promotion of investigational devices, and specify recordkeeping, reporting and monitoring responsibilities of trial sponsors and investigators. If the device presents a "significant risk," as defined by the FDA, the agency requires the device sponsor to submit an IDE application to the FDA, which must become effective prior to commencing human clinical studies. A significant risk device is one that presents a potential for serious risk to the health, safety or welfare of a patient and either is implanted, used in supporting or sustaining human life, substantially important in diagnosing, curing, mitigating or treating disease or otherwise preventing impairment of human health, or otherwise presents a potential for serious risk to a patient.

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An IDE application must be supported by appropriate pre-clinical data, such as animal and laboratory test results, showing that the device has a safety profile appropriate for human testing and that the trial protocol is scientifically sound. The IDE will automatically become effective 30 days after receipt by the FDA, unless the FDA expressly approves or denies the application in writing or notifies the sponsor that the investigation is on hold and may not begin until the sponsor provides supplemental information about the investigation that satisfies the agency's concerns. If the FDA determines that there are deficiencies or other concerns with an IDE that require modification of the trial, the FDA may permit a clinical trial to proceed under a conditional approval or the sponsor and the FDA must resolve any outstanding concerns before the clinical trial can begin. In addition, the trial must be approved by, and conducted under the oversight of, an institutional review board, or IRB, for each clinical site. If the device presents a non-significant risk to the patient according to criteria established by FDA as part of the IDE regulations, a sponsor may begin the clinical trial after obtaining approval for the trial by one or more IRBs without separate authorization from the FDA, but must still comply with abbreviated IDE requirements, such as monitoring the investigation, ensuring that the investigators obtain informed consent, and labeling and record-keeping requirements.

As part of its clinical trial oversight responsibilities, an IRB must review and approve, among other things, the trial protocol and informed consent information to be provided to clinical trial subjects. An IRB must operate in compliance with FDA regulations. Information about certain clinical studies, including details of the protocol and eventually trial results, also must be submitted within specific timeframes to the National Institutes of Health, or NIH, for public dissemination on the ClinicalTrials.gov data registry. Information related to the product, patient population, phase of investigation, trial sites and other aspects of the clinical trial are made public as part of the trial registration. Sponsors are also obligated to disclose the results of their clinical studies after completion. Disclosure of the results of these studies can be delayed in some cases for up to two years after the date of completion of the trial. Failure to timely register a covered clinical study or to submit study results as provided for in the law can give rise to civil monetary penalties and also prevent the non-compliant party from receiving future grant funds from the federal government. The NIH Final Rule on ClinicalTrials.gov registration and reporting requirements became effective in 2017, and the government has brought enforcement actions against non-compliant clinical trial sponsors.

Progress reports detailing the results of the clinical studies must be submitted at least annually to the FDA and more frequently if unanticipated serious adverse events, or SAEs, occur. The FDA or the sponsor may suspend or terminate a clinical trial at any time on various grounds, including a finding that the research subjects or patients are being exposed to an unacceptable health risk. Similarly, an IRB can suspend or terminate approval of a clinical trial at its institution if the clinical trial is not being conducted in accordance with the clinical protocol, GCP, or other IRB requirements or if the investigational product has been associated with unexpected serious harm to patients.

In the Consolidated Appropriations Act for 2023, Congress amended the FDCA to require the sponsor of any pivotal clinical trial that will be used to demonstrate the safety and effectiveness of a medical device marketing authorization submission to develop a diversity action plan for such trial, and if submission of an IDE application is required, to submit such diversity action plan to the FDA. The action plan must include the sponsor's diversity goals for enrollment, as well as a rationale for the goals and a description of how the sponsor will meet them. The FDA may grant a waiver for some or all of the requirements for a diversity action plan. If FDA objects to a sponsor's diversity action plan and requires the sponsor to amend the plan or take other actions, it may delay trial initiation.

*Post-Marketing Restrictions and Enforcement*

After a device is cleared or approved for commercialization by the FDA, a medical device remains subject to ongoing regulatory requirements such as:

● establishment registration and device listing with the FDA;

● quality system regulations, which require manufacturers, including third-party manufacturers, to follow stringent design, testing, control, documentation and other quality assurance procedures during all aspects of the design and manufacturing process;

● labeling and marketing regulations, which require that advertising and promotional materials about the cleared or approved device are truthful, not misleading, fairly balanced and provide adequate directions for use and that all claims are substantiated, and also prohibit the promotion of devices for uncleared or unapproved (also known as "off -label") uses and impose other restrictions on labeling;

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● medical device reporting regulations, which require that a manufacturer report to the FDA if a device it markets may have caused or contributed to a death or serious injury, or has malfunctioned and the device or a similar device marketed by the manufacturer would be likely to cause or contribute to a death or serious injury, if the malfunction were to recur;

● correction, removal and recall reporting regulations, which require that manufacturers report to the FDA field corrections and product recalls or removals if undertaken to reduce a risk to health posed by the device or to remedy a violation of the FDCA that may present a risk to health;

● the FDA's recall authority, whereby the agency can order device manufacturers to recall from the market a product that is in violation of governing laws and regulations;

● post-market surveillance activities and regulations, which apply when deemed by the FDA to be necessary to protect the public health or to provide additional safety and effectiveness data for the device; and

● periodic scheduled or unscheduled inspections by the FDA to assess compliance with applicable regulations, which could result in the shutdown of, or restrictions on, our manufacturing operations and the recall or seizure of our products.

The medical device reporting requirements also extend to healthcare facilities that use medical devices in providing care to patients, or "device user facilities," which include hospitals, ambulatory surgical facilities, nursing homes, outpatient diagnostic facilities, or outpatient treatment facilities, but not physician offices. A device user facility must report any device-related death to both the FDA and the device manufacturer, or any device-related serious injury to the manufacturer (or, if the manufacturer is unknown, to the FDA) within 10 days of the event. Device user facilities are not required to report device malfunctions that would likely cause or contribute to death or serious injury if the malfunction were to recur but may voluntarily report such malfunctions through MedWatch, the FDA's Safety Information and Adverse Event Reporting Program.

The FDA has the authority to require the recall of commercialized medical device products in the event of material deficiencies or defects in design or manufacture. The authority to require a recall must be based on an FDA finding that there is reasonable probability that the device would cause serious adverse health consequences or death. A manufacturer may, under its own initiative, recall one or more of its products if any distributed devices fail to meet established specifications, are otherwise misbranded or adulterated under the FDCA, or if any other material deficiency is found. A device manufacturer must report to the FDA any correction, removal or recall of its devices, if such action is taken to reduce a risk to health posed by such devices or to remedy a violation of the FDCA caused by such devices that may present a risk to health, within 10 working days after the recall is initiated.

The failure to comply with applicable regulatory requirements can result in enforcement action by the FDA, which may include any of the following sanctions:

● warning letters, fines, injunctions or civil penalties;

● recalls, detentions or seizures of products;

● operating restrictions;

● delays in the introduction of products into the market;

● total or partial suspension of production;

● delay or refusal of the FDA or other regulators to grant 510(k) clearance, PMA approvals, or other marketing authorization to new products;

● withdrawals of marketing authorizations; or

● in the most serious cases, criminal prosecution.

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To ensure compliance with regulatory requirements, medical device manufacturers are subject to market surveillance and periodic, pre-scheduled or unannounced inspections by the FDA, and these inspections may include the manufacturing facilities of contract manufacturers. Manufacturing processes for medical devices are required to comply with the applicable portions of the QSR/QMSR, which cover the methods and the facilities and controls for the design, manufacture, testing, production, processes, controls, quality assurance, labeling, packaging, distribution, installation and servicing of finished devices intended for human use. The QSR/QMSR also requires, among other things, maintenance of a device master file, device history file, and complaint files. Failure to maintain compliance with applicable quality system requirements could result in the shutdown of, or restrictions on, manufacturing operations and the recall or seizure of marketed products.

*Breakthrough Device Designation*

The 21st Century Cures Act, which was signed into law on December 13, 2016, established and directed FDA to implement the Breakthrough Devices Program. Under the program, device manufacturers may voluntarily request breakthrough designation for devices that may provide for more effective treatment or diagnosis of life-threatening or irreversibly debilitating human disease or conditions over currently available technology and that meet at least one of the following criteria:

● the device represents breakthrough technology;

● there are no approved or cleared alternatives for the device;

● the device offers significant advantages over existing approved or cleared alternatives; or

● availability of the device is in the best interest of patients.

The goal of the Breakthrough Devices Program is to expedite the development and prioritize the review of certain medical devices that provide for more effective treatment or diagnosis of life-threatening or irreversibly debilitating diseases or conditions. A breakthrough device designation offers multiple benefits to the device manufacturer, including prioritized review of the pre-market submission for the device, opportunities to interact directly with FDA's experts throughout the process, and engagement of FDA senior management.

Even if a product qualifies for Breakthrough Device designation, the FDA may later decide that the device no longer meets the conditions for qualification or decide not to expedite the time period for pre-market review or authorization. The Breakthrough Devices Program does not change the scientific or medical standards for marketing authorization or the quality of evidence necessary to support authorization but may expedite the development or pre-market review process.

*Federal Trade Commission Regulatory Oversight*

Our advertising for our products is subject to federal truth-in-advertising laws enforced by the Federal Trade Commission, or FTC, as well as comparable state consumer protection laws. Under the Federal Trade Commission Act, or FTC Act, the FTC is empowered, among other things, to (a) prevent unfair methods of competition and unfair or deceptive acts or practices in or affecting commerce; (b) seek monetary redress and other relief for conduct injurious to consumers; and (c) gather and compile information and conduct investigations relating to the organization, business, practices, and management of entities engaged in commerce. The FTC has very broad enforcement authority, and failure to abide by the substantive requirements of the FTC Act and other consumer protection laws can result in administrative or judicial penalties, including civil penalties, injunctions affecting the manner in which we would be able to market services or products in the future, or criminal prosecution.

*Federal Communications Commission Regulation*

The Genio system includes a wireless radio frequency transmitter and receiver and, therefore, is subject to equipment authorization requirements in the United States. The Federal Communications Commission, or FCC, requires advance clearance of all radio frequency devices before they can be imported into, sold or marketed in the United States. These clearances ensure that the proposed products comply with FCC radio frequency emission and power level standards and will not cause interference.

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*Healthcare Law and Regulation*

We must comply with various U.S. federal and state laws, rules and regulations pertaining to healthcare fraud and abuse, including anti-kickback laws, false claims laws and price transparency reporting laws, rules and regulations. Violations of the fraud and abuse laws are punishable by criminal and civil sanctions, including, in some instances, exclusion from participation in federal and state healthcare programs, including Medicare and Medicaid. These laws include the following:

● the federal Anti-Kickback Statute prohibits, among other things, persons from knowingly and willfully soliciting, offering, receiving or providing remuneration, directly or indirectly, in cash or in kind, to induce or reward either the referral of an individual for, or the purchase, order or recommendation of, any good or service, for which payment may be made, in whole or in part, under a federal healthcare program such as Medicare and Medicaid. A person or entity does not need to have actual knowledge of the Anti-Kickback Statute or specific intent in order to violate it;

● the federal False Claims Act imposes civil penalties, and provides for civil whistleblower or qui tam actions, against individuals or entities for knowingly presenting, or causing to be presented, to the federal government, claims for payment that are false or fraudulent or making a false statement to avoid, decrease or conceal an obligation to pay money to the federal government. In addition, the government may assert that a claim including items or services resulting from a violation of the federal Anti-Kickback Statute constitutes a false or fraudulent claim for purposes of the federal False Claims Act;

● HIPAA imposes criminal and civil liability for executing a scheme to defraud any healthcare benefit program or making false statements relating to healthcare matters;

● HIPAA, as amended by the Health Information Technology for Economic and Clinical Health Act and its implementing regulations, also imposes obligations, including mandatory contractual terms, with respect to safeguarding the privacy, security and transmission of individually identifiable health information;

● the federal false statements statute prohibits knowingly and willfully falsifying, concealing or covering up a material fact or making any materially false statement in connection with the delivery of or payment for healthcare benefits, items or services;

● the federal transparency requirements under the Physician Payments Sunshine Act require manufacturers of FDA-approved drugs, devices, biologics and medical supplies covered by Medicare or Medicaid to report, on an annual basis, to the Centers for Medicare and Medicaid Services, information related to payments and other transfers of value to physicians, teaching hospitals, and certain advanced non-physician health care practitioners, as well as ownership and investment interests held by physicians and their immediate family members; and

● analogous state and foreign laws and regulations, such as state anti-kickback and false claims laws, may apply to sales or marketing arrangements and claims involving healthcare items or services reimbursed by nongovernmental third-party payors, including private insurers.

The majority of states also have statutes or regulations similar to the aforementioned federal laws, some of which are broader in scope and apply to items and services reimbursed under Medicaid and other state programs, or, in several states, apply regardless of the payor. Some state laws require medical device companies to comply with the relevant industry's voluntary compliance guidelines and the relevant compliance guidance promulgated by the federal government in addition to requiring device manufacturers to report information related to payments to physicians and other health care providers or marketing expenditures.

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State and foreign laws also govern the privacy and security of health information in some circumstances, many of which differ from each other in significant ways and often are not preempted by HIPAA, thus complicating compliance efforts. We also may be subject to, or may in the future become subject to, U.S. federal and state, and foreign laws and regulations imposing obligations on how we collect, use, disclose, store and process personal information. Nyxoah S.A. is not a covered entity or a business associate under HIPAA; however, we are indirectly affected by HIPAA because the protected health information held by investigators conducting our clinical trials is subject to HIPAA and can only be used for Nyxoah research consistent with HIPAA requirements imposed on those investigators. In addition, state laws, such as the California Consumer Privacy Act (CCPA), govern the privacy and security of the personal information of individuals residing in such states, and may in certain circumstances, apply to health information. In addition to California, other states have implemented laws protecting identifiable health and personal information, and many of these laws differ from each other in significant ways and may not be preempted by HIPAA, thus complicating compliance efforts.

Violation of any of the federal and state healthcare laws may result in penalties, including without limitation, civil, criminal and/or administrative penalties, damages, fines, disgorgement, exclusion from participation in government programs, such as Medicare and Medicaid, injunctions, private "qui tam" actions brought by individual whistleblowers in the name of the government, or refusal to enter into government contracts, contractual damages, reputational harm, administrative burdens, diminished profits and future earnings, and the curtailment or restructuring of operations. Our actual or perceived failure to comply with healthcare and data privacy laws could result in liability or reputational harm and could harm our business. Ensuring compliance with such laws could also impair our efforts to maintain and expand our customer base and thereby decrease our future revenues.

*Coverage and Reimbursement*

Sales of the Genio system and any of our current or future product candidates, if approved, will depend, in part, on the extent to which the procedures using the Genio system and any product candidates are covered by third-party payors, such as government healthcare programs, commercial insurance and managed healthcare organizations. Third-party payors are increasingly limiting coverage and reducing reimbursements for medical products and services. In addition, the U.S. government, state legislatures and foreign governments have continued implementing cost-containment programs, including price controls, and restrictions on coverage and reimbursement. Third-party payors are increasingly challenging the price, examining the medical necessity and reviewing the cost-effectiveness of medical devices and medical services, in addition to questioning their safety and efficacy. Adoption of price controls and cost-containment measures, and adoption of more restrictive policies in jurisdictions with existing controls and measures, could further limit our net sales and results.

In the United States, reimbursement for professional services performed at a facility by physicians is typically reported under billing codes issued by the American Medical Association, or AMA, known as Current Procedural Terminology, or CPT, codes. Physician reimbursement under Medicare generally is based on a fee schedule and determined by the relative value of the professional service rendered. Under the Medicare program, hospital outpatient services are reported by CPT codes and assigned to clinically relevant Ambulatory Payment Classifications, or APCs, which are used to determine the payment amount for services provided. As part of the final Hospital Outpatient Prospective Payment System and Ambulatory Surgery Center rule for 2026, CMS assigned CPT code 64568 for cranial nerve stimulation implants (including the Genio system hypoglossal nerve stimulator) to New Technology APC 1580.

Moreover, the process for determining whether a third-party payor will provide coverage for a product or procedure may be separate from the process for establishing the reimbursement rate that such a payor will pay for the product or procedure. A payor's decision to provide coverage for a product or procedure does not imply that an adequate reimbursement rate will be approved. Further, one payor's determination to provide coverage for a product or procedure does not assure that other payors will also provide coverage. Adequate third-party reimbursement may not be available to enable us to maintain price levels sufficient to ensure profitability.

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*Healthcare Reform*

The FDA's and other regulatory authorities' policies may change and future legislative and regulatory proposals may prevent, limit or delay regulatory authorization of our product candidates or, more broadly, may materially impact the ability of the FDA and other regulatory agencies to operate as they have historically operated. We cannot be sure whether additional legislative changes will be enacted, or whether any of the FDA's regulations, guidance or interpretations will be changed, or what the impact of such changes on the agency and its scientific review staff, if any, may be. For example, the next FDA user fee reauthorization package entered the stakeholder negotiation phase in mid-2025, and any agreement is expected to be sent to Congress in early 2027 for purposes of initiating the legislative process. Reauthorization of the medical device user fee program must be finalized by Congress by the end of September 2027 in order to avoid a disruption in FDA's review goals for activities supported by user fees. If we are slow or unable to adapt to changes in existing requirements or the adoption of new requirements or policies, or if we are not able to maintain regulatory compliance, we may lose any marketing authorization that we otherwise may have obtained, and we may not achieve or sustain profitability, which would adversely affect our business, prospects, financial condition and results of operations.

In December 2022, the U.S. Congress enacted the Consolidated Appropriations Act for 2023, an omnibus appropriations bill, which included amendments to the FDCA under the Food and Drug Omnibus Reform Act of 2022, or FDORA. In addition to the requirement that sponsors of pivotal trials submit diversity action plans for pivotal trials (see "Government Regulation-Regulatory Landscape in the United States-Device Clinical Studies"), FDORA included new requirements for cyber devices, defined as any medical device that is or includes software that is validated, installed, or authorized by the manufacturer; can connect to the internet; and may be vulnerable to cybersecurity threats. Under the FDORA amendments to the FDCA, any application for marketing authorization of a cyber device must include a software bill of materials and a cybersecurity plan describing the methods by which the manufacturer will monitor, identify and address cybersecurity vulnerabilities. Any failure by a cyber device manufacturer to comply with applicable cybersecurity requirements is considered a violation of the FDCA and will subject the manufacturer to enforcement actions and possibly legal sanctions.

In the United States, there have been, and we expect there will continue to be, a number of legislative and regulatory changes to the healthcare system. In March 2010, the Patient Protection and Affordable Care Act, as amended by the Health Care and Education Reconciliation Act of 2010, (collectively, the "ACA") was signed into law and substantially changed the way healthcare is financed by both governmental and private insurers in the United States. The ACA contains a number of provisions, including those governing enrollment in federal healthcare programs, reimbursement adjustments and fraud and abuse changes. Additionally, the ACA provided incentives to programs that increase the federal government's comparative effectiveness research and implemented payment system reforms including a national pilot program on payment bundling to encourage hospitals, physicians and other providers to improve the coordination, quality and efficiency of certain healthcare services through bundled payment models.

Legislative and regulatory changes under the ACA remain possible, although it is unknown what form any such changes or any law would take, and how or whether it may affect the medical device industry as a whole or our business in the future. We expect that changes or additions to the ACA, the Medicare and Medicaid programs and changes stemming from other healthcare reform measures, especially with regard to healthcare access, financing or other legislation in individual states, could have a material adverse effect on the healthcare industry in the United States.

Moreover, there has recently been heightened governmental scrutiny, including increasing legislative and enforcement interest, over the manner in which manufacturers set prices for their marketed healthcare products, which has resulted in several Congressional inquiries and proposed and enacted legislation designed, among other things, to bring more transparency to healthcare product pricing, review the relationship between pricing and manufacturer patient programs and reform government program reimbursement methodologies for healthcare products. Individual states in the United States have also become increasingly active in implementing regulations designed to control healthcare product pricing, including price or patient reimbursement constraints, discounts, restrictions on certain product access and marketing cost disclosure and transparency measures and, in some cases, mechanisms to encourage importation of healthcare products from other countries. Furthermore, there has been increased interest by third-party payors and governmental authorities in reference pricing systems and publication of discounts and list prices.

#### Data Privacy and Security
Data privacy and security is governed by both European and national legislation.

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At the European Union level, data protection is essentially regulated by Regulation (EU) 2016/679 of the European Parliament and of the Council of April 27, 2016, or the General Data Protection Regulation (GDPR) and -specifically with respect to electronic communications- by Directive 2002/58/EC of the European Parliament and of the Council of July 12, 2002 concerning the processing of personal data and the protection of privacy in the electronic communications sector, or the e-privacy Directive.

Since EU regulation supersedes congruent national data privacy laws, the GDPR is binding in its entirety and directly applicable in each member state. It was primarily intended to harmonize data protection law in the European Union, to improve data protection enforcement and to strengthen the internal market. Nevertheless, the GDPR contains a number of opening clauses that allow EU member states to create specific national laws relating to individual data processing activities or requirements, such as the protection of employee data. Accordingly, EU member states have enacted national implementation acts which accompany the GDPR.

Under the GDPR, the regulatory requirements include that personal data may only be collected for specified, explicit and legitimate purposes based on a lawful basis. Personal data may only be collected and processed in a manner consistent with those purposes. Personal data must also be adequate, relevant and limited to what is necessary in relation to the purposes for which it is processed. It must be processed in a manner that ensures transparency to the data subject (*i.e.*, an identified or identifiable natural person to whom the personal data relates). The GDPR stipulates strict requirements regarding the processing of special categories of personal data (such as data concerning health, genetic and biometric information), on the duties to prepare documentation and to furnish proof of compliance with the requirements of the GDPR. The rights of data subjects have been strengthened and include, among others, a right to require information about their data being processed and, where applicable, the right to "data portability" as well as the right to restrict certain processing of their data as well as a "right to be forgotten" pursuant to which data subjects may require that their data is to be deleted when there is a problem with the underlying legality of the processing or where they withdraw their consent. The GDPR also provides restrictive requirements as regards automated decision making and profiling activities, which could impact marketing activities based on such processing of data.

As part of our obligations under the GDPR, we must implement appropriate technical and organizational measures to ensure a level of security appropriate to the organization's processing requirements and risk. Accordingly, certain cyber security requirements must be fulfilled to ensure that data is processed and stored safely. Organizations must notify the relevant supervisory authority about data breaches within 72 hours when acting as data controller, and in some instances, provide notification to data subjects. In terms of (cyber) security, account should also be taken of the so-called NIS2 framework, which derives from Directive (EU) 2022/2555 of the European Parliament and of the Council of 14 December 2022 on measures for a high common level of cybersecurity across the Union, or the "NIS2 Directive". Unlike the GDPR, the NIS2 Directive is not directly applicable and must be transposed into member states' national laws. The NIS2 Directive imposes more stringent requirements in the field of cybersecurity in 18 critical sectors. Our activities do not come within the ambit of the NIS2 Directive, which only concerns entities manufacturing medical devices to the extent that they are considered to be critical during a public health emergency (public health emergency critical devices list) within the meaning of Article 22 of EU Regulation (EU) 2022/123, which is not the case for our products.

Among other requirements, the GDPR regulates the transfer of personal data subject to the GDPR to third countries, outside the EEA. Such transfers are authorized to the extent they meet the conditions laid down in the GDPR for such transfers. The GDPR provides for different means for personal data to be legally transferred to third countries, including adequacy decisions, appropriate safeguards such as standard contractual clauses, and binding corporate rules. Certain legal developments in Europe have created complexity and uncertainty regarding such transfers, especially when it comes to transfers to the United States of America.

Navigating transfers of personal data to US-based organizations has not been easy in recent years, following legal challenges brought against several international data transfer instruments set forth under the GDPR. On July 16, 2020 for instance, the Court of Justice of the European Union, or the CJEU, invalidated the EU-U.S. Privacy Shield Framework, or the Privacy Shield, under which personal data could be transferred from the European Union to U.S. entities who had self-certified under the Privacy Shield scheme. US laws were considered falling short of guaranteeing EU individuals an essentially equivalent level of data protection as in the EU due to far-reaching possibilities of surveillance that existed under US national security laws. Following the Schrems-II judgment, organizations transferring personal data to the US relied on standard contractual clauses. While the CJEU upheld the adequacy of the standard contractual clauses (a standard form of contract approved by the European Commission as an adequate third country personal data transfer mechanism and potential alternative to the Privacy Shield), it made clear that reliance on such clauses alone may not necessarily be sufficient in all circumstances. Uncertainties were lifted with the adoption by the European Commission of a new adequacy decision relating to transfers of personal data to organizations participating in the Data Privacy Framework.

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On July 10, 2023, the European Commission adopted an adequacy decision for a new mechanism for transferring data from the EU to the United States, or the EU-US Data Privacy Framework, which provides EU individuals with several new rights, including the right to obtain access to their data, or obtain correction or deletion of incorrect or unlawfully handled data, and allows US companies to self-certify to the U.S. Department of Commerce their compliance with a set of agreed privacy principles in order to freely receive EU personal data. The adequacy decision followed the signing of an executive order introducing new binding safeguards to address the points raised in the Schrems II-judgment. Notably, the new obligations are geared to ensure that data can be accessed by U.S. intelligence agencies only to the extent necessary and proportionate and to establish an independent and impartial redress mechanism to handle complaints from Europeans concerning the collection of their data for national security purposes. The European Commission will continually review developments in the United States along with its adequacy decision. Adequacy decisions can be adapted or even withdrawn in the event of developments affecting the level of protection in the applicable jurisdiction. In this respect it must be noted that several privacy organizations are calling for such a withdrawal and it seems that several changes undertaken by the Trump administration could lead to a degraded function of the EU-US Data Privacy Framework so that it is uncertain whether the CJEU would uphold it in a Schrems III-like case. New challenges of the EU-US Data Privacy Framework should be expected too, despite the General Court's judgment of September 3, 2025 rejecting the first legal challenge brought against the adequacy decision.

If the EU-US Data Privacy Framework would be withdrawn or otherwise struck down, if the recipient of personal data has not been self-certified under it or if transfers concern other non-EU/EEA countries that do not benefit from an adequacy decision, international data transfers must occur through another legal basis.

As indicated, while the CJEU upheld the adequacy of the standard contractual clauses, reliance on this contractual mechanism alone may not always be sufficient in all circumstances. Use of, and reliance on, the standard contractual clauses must now be assessed on a case-by-case basis taking into account the legal regime applicable in the destination country, including, in particular, applicable surveillance laws and rights of individuals, and additional measures and/or contractual provisions may need to be put in place; however, the nature of these additional measures is currently uncertain. The CJEU went on to state that if a competent supervisory authority believes that the standard contractual clauses cannot be complied with in the destination country and that the required level of protection cannot be secured by other means, such supervisory authority is under an obligation to suspend or prohibit that transfer.

On a general note, failure to comply with the GDPR provides for substantial fines in case of noncompliance (up to the greater of €20 million or 4% of our global annual turnover for the preceding financial year for the most serious violations, as well as the right to compensation for financial or non-financial damages claimed by individuals under Article 82 of the GDPR), potentially high-stakes tort claims for material and immaterial damages (e.g., for infringements of privacy rights) and a general burden of proof for companies. Individual EU member state implementation laws such as the *Bundesdatenschutzgesetz*, or BDSG, in Germany also provide criminal sanctions for specific violations.

Privacy regulations, such as the GDPR, concerning the use of web analysis are particularly relevant to our online platform. Web analysis technologies (*e.g.*, processing of cookies or tracking records such as through Google Analytics) process personal data in order to enable the operator of a website to personalize its offers and marketing to better match the client's interests. Certain web analysis tools anonymize or pseudonymize collected data, but the use of such tools is nonetheless regulated by data privacy laws. For example, the use of cookies is regulated both by the GDPR and by the ePrivacy Directive, that provides for an opt-in regime pursuant to which the use of technically non-necessary cookies and comparable tracking technologies requires an informed consent of the end-user of a device.

Finally, based on its data strategy, the European Union plans to comprehensively revise and update the legal framework for the handling of data, for example through the recently adopted Digital Markets Act and the Digital Services Act. In the medical sector, it is worth noting that Regulation (EU) 2025/327 of the European Union and of the Council of 11 February 2025 on the European Health Data Space entered into force on 26 March 2025, or the EHDS Regulation, which lays down an EU harmonized framework on the secondary use of health data, in particular for research. Access to such data can be applied for via a health data access body, or HDAB, for access to electronic health data held by a third party (e.g., hospitals and HCPs). Full implementation of the EHDS Regulation will be spread over the upcoming ten years.

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*Data Privacy and Security Laws in Belgium*

In Belgium, the legislator adopted implementing legislation following the GDPR. Notably, the Act of July 30, 2018 on the Protection of Natural Persons with regard to the Processing of Personal Data, or the Data Protection Act, addresses various national substantive aspects of the GDPR and introduces several specifications and derogations. The Data Protection Act stipulates 13 years old as the age from which children may provide consent for the use of an information service. This is lower than the age of 16 set by the GDPR. Furthermore, the Data Protection Act imposes additional security measures in relation to sensitive data. An entity processing genetic data, biometric data, data concerning health or data related to criminal convictions and offences must maintain a list of the categories of persons who have access to such data, together with a description of their function related to processing such data. When requested, the list must be disclosed to the competent supervisory authority.

The ePrivacy Directive regulates, among other things, the processing of traffic and location data, unsolicited commercial communications and online targeting of consumers by storing information on the equipment of end-users (*e.g.*, cookies). These requirements have been implemented in Belgium in the Act of June 13, 2005 on Electronic Communications, or the Electronic Communications Act. As regards cookies, Article 129 of the Electronic Communications Act follows the wording of the ePrivacy Directive closely. As a result, Article 129 of the Electronic Communication Act requires prior informed consent and does not allow for the user's consent to be expressed by usage of the appropriate settings of a browser or other application. Furthermore, consumer data may be stored and processed only as long as this is necessary for the provision of services to that consumer.

With regards to cookies, the Belgian Data Protection Authority also indicated that it will treat this as a top priority. The Belgian Data Protection Authority has been proactively looking for cookie infringements on (press) websites and placed those websites under scrutiny in recent case-law. Moreover, the EDPB has published the Cookie Banner Taskforce Report, which identifies common minimum thresholds for the data protection authorities in relation to cookies.

*Data Privacy and Security Laws in the United States*

Medical device companies may be subject to U.S. federal and state health information privacy, security and data breach notification laws, which may govern the collection, use, disclosure and protection of health- related and other personal information.

HIPAA imposes privacy, security and breach reporting obligations with respect to individually identifiable health information upon "covered entities" (health plans, healthcare clearinghouses and certain health care providers), and their respective business associates, individuals or entities that create, received, maintain or transmit protected health information in connection with providing a service for or on behalf of a covered entity. HIPAA mandates the reporting of certain breaches of health information to the U.S. Department of Health and Human Services, or HHS, affected individuals and if the breach is large enough, the media. Entities that are found to be in violation of HIPAA as the result of a breach of unsecured protected health information, or PHI, a complaint about privacy practices or an audit by HHS, may be subject to significant civil, criminal and administrative fines and penalties and/or additional reporting and oversight obligations if required to enter into a resolution agreement and corrective action plan with HHS to settle allegations of HIPAA non-compliance.

Even when HIPAA does not apply, failing to take appropriate steps to keep consumers' personal information secure constitutes unfair acts or practices in or affecting commerce in violation of Section 5(a) of the Federal Trade Commission Act, 15 U.S.C § 45(a). The FTC expects a company's data security measures to be reasonable and appropriate in light of the sensitivity and volume of consumer information it holds, the size and complexity of its business, and the cost of available tools to improve security and reduce vulnerabilities. Personally identifiable health information is considered sensitive data that merits stronger safeguards. The FTC's guidance for appropriately securing consumers' personal information is similar to what is required by the HIPAA Security Rule.

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Various states, such as California and Massachusetts, have implemented similar privacy laws and regulations, such as the California Confidentiality of Medical Information Act, that impose restrictive requirements, in some cases more stringent than HIPAA, regulating the use and disclosure of health information and other personally identifiable information. In addition to fines and penalties imposed upon violators, some of these state laws also afford private rights of action to individuals who believe their personal information has been misused. Furthermore, California enacted the California Consumer Privacy Act, or CCPA, which took effect on January 1, 2020, became enforceable by the California Attorney General on July 1, 2020, and has been dubbed the first "GDPR-like" law in the United States. The CCPA gives California residents expanded rights to access and delete their personal information, opt out of certain personal information sharing and receive detailed information about how their personal information is used by requiring covered companies to provide new disclosures to California consumers (as that term is broadly defined). The CCPA provides for civil penalties for violations, as well as a private right of action for data breaches that is expected to increase data breach litigation. More recently, the California Privacy Rights Act, or CPRA, became law in California. The CPRA imposes additional data protection obligations on certain companies doing business in California, including additional consumer rights processes, limitations on data uses, new audit requirements for high-risk data, and opt outs for certain uses of sensitive data. It also created a new California data protection agency authorized to issue substantive regulations, which could lead to increased privacy and information security enforcement. The majority of the CPRA provisions became effective on January 1, 2023, and additional compliance investment and potential business process changes may be required. Although the CCPA currently exempts certain health-related information, including clinical trial data, the CCPA and the CPRA may increase our compliance costs and potential liability. A number of other states have either enacted their own omnibus privacy laws or continued to deliberate and introduce similar privacy law proposals. Such laws may have potentially conflicting requirements that would make compliance challenging.

The interplay of federal and state laws may be subject to varying interpretations by courts and government agencies, creating complex compliance issues for us and our affiliates and partners and potentially exposing us to additional expense, adverse publicity and liability. Further, as regulatory focus on privacy issues continues to increase and laws and regulations concerning the protection of personal information expand and become more complex, these potential risks to our business could intensify.

The legislative and regulatory landscape for privacy and data security continues to evolve, and there has been an increasing focus on privacy and data security issues which may affect our business. Failure to comply with current and future laws and regulations could result in government enforcement actions (including the imposition of significant penalties), criminal and civil liability for us and our officers and directors, private litigation and/or adverse publicity that negatively affects our business.

#### FCPA and Other Anti-Bribery and Anti-Corruption Laws.
Our operations are subject to anti-corruption laws, including FCPA; the Bribery Act; and other anti-corruption laws that apply in countries where we do business. The FCPA, the Bribery Act, and these other laws generally prohibit Nyxoah and our employees and intermediaries from authorizing, promising, offering, or providing, directly or indirectly, a financial or other advantage to government officials or other persons to induce them to improperly perform a relevant function or activity (or reward them for such behavior).

In general, the FCPA prohibits offering to pay, paying, promising to pay, or authorizing the payment of money or anything of value to a foreign official in order to influence any act or decision of the foreign official in his or her official capacity or to secure any other improper advantage in order to obtain or retain business for or with, or in order to direct business to, any person. The prohibitions apply not only to payments made to "any foreign official," but also those made to "any foreign political party or official thereof," to "any candidate for foreign political office" or to any person, while knowing that all or a portion of the payment will be offered, given, or promised to anyone in any of the foregoing categories. "Foreign officials" under the FCPA include officers or employees of a department, agency, or instrumentality of a foreign government. The term "instrumentality" is broad and can include state- owned or state-controlled entities.

Importantly, United States authorities that enforce the FCPA, including the Department of Justice, deem most healthcare professionals and other employees of foreign hospitals, clinics, research facilities and medical schools in countries with public healthcare or public education systems to be "foreign officials" under the FCPA. When we interact with foreign healthcare professionals and researchers in testing and marketing our products abroad, we must have policies and procedures in place sufficient to prevent us and agents acting on our behalf from providing any bribe, gift or gratuity, including excessive or lavish meals, travel or entertainment in connection with marketing our products and services or securing required permits and approvals such as those needed to initiate clinical studies in foreign jurisdictions.

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The FCPA also obligates companies whose securities are listed in the United States to comply with accounting provisions requiring the maintenance of books and records that accurately and fairly reflect all transactions of the corporation, including international subsidiaries, and the development and maintenance of an adequate system of internal accounting controls for international operations. The SEC is involved with the books and records provisions of the FCPA.

We are also subject to other laws and regulations governing our international operations, including regulations administered by the governments of the United Kingdom and the United States, and authorities in the EU, including applicable export control regulations, economic sanctions and embargoes on certain countries and persons, anti-money laundering laws, import and customs requirements and currency exchange regulations.

#### Employees and Human Capital Resources
As of December 31, 2025, we employed 153.7 full-time equivalents (including employees and consultants), of which 67.1 were based in Europe (Belgium, Germany and the United Kingdom), 6.6 were based in Israel, two were based in Australia, and 78 were based in the United States. None of our employees are represented by labor unions or covered by company specific bargaining agreements.

We believe that one of our key strengths is our employee base, which has extensive know-how across research, manufacturing, quality-control, engineering software programming and marketing and sales. We also believe that developing a diverse, equitable and inclusive culture is critical to continuing to attract and retain the top talent necessary for our long-term success and strategy. We value diversity at all levels and continue to focus on extending our diversity and inclusion initiatives across our entire workforce, including the expansion of individuals with diverse backgrounds in leadership.

Our principles of accountability, honesty, integrity and customer-focused, serve as our cultural pillars. We focus our efforts on creating a collaborative environment where our colleagues feel respected and valued. We provide our employees with competitive compensation, opportunities for equity ownership and a robust employment package, including health care, disability and long-term planning insurance, retirement planning and paid time off. In addition, we regularly interact with our employees to gauge employee satisfaction and identify areas of focus.

#### Legal Proceedings
From time to time we may become involved in legal proceedings or be subject to claims arising in the ordinary course of our business.

On May 30, 2025, Inspire Medical Systems, Inc., or Inspire, filed a lawsuit against Nyxoah SA and Nyxoah, Inc, together Nyxoah, in the United States District Court for the District of Delaware, alleging that the Genio system infringes Inspire's U.S. Patent Nos. 10,898,709, 11,806,526 and 11,850,424, or the Inspire Asserted Patents. Inspire's complaint seeks customary remedies for patent infringement. Nyxoah has filed a counterclaim seeking declaratory judgment that the Genio system does not infringe the Inspire patents, and that those patents are invalid. We intend to vigorously defend against Inspire's claims.

On September 15, 2025, Nyxoah filed a lawsuit against Inspire, again in the U.S. District Court for the District of Delaware, alleging that the Inspire IV and Inspire V systems infringe U.S. Patent Nos. 8,700,183, 9,415,215, and 9,415,216. Like the Inspire complaint, Nyxoah's complaint seeks customary remedies for patent infringement. The deadline for Inspire to respond to Nyxoah's complaint had been stayed pending the court's final ruling on our motion to disqualify Inspire's counsel. On February 16, 2026, Inspire withdrew its objections to the court's initial ruling on that issue, and the court lifted the stay. Inspire filed its initial response to Nyxoah's lawsuit on March 23, 2026, seeking dismissal of certain of Nyxoah's claims. We expect the court will soon set a schedule for Nyxoah's case.

On December 1, 2025, Nyxoah SA filed two actions against Inspire and Inspire Medical Systems Europe GmbH, together Inspire Europe, in the Unified Patent Court in Munich, Germany, alleging that the Inspire IV system infringes two European patents, EP 2 760 528 B1 and EP 2 760 534 B1. Nyxoah's complaints seek damages and injunctive relief against Inspire Europe.

On December 18, 2025, Nyxoah filed petitions for *inter partes* review of the Inspire Asserted Patents, asking the U.S. Patent and Trademark Office to determine that the claims of those patents are unpatentable (*i.e.* invalid). Inspire filed initial written responses to those petitions on March 2, 2026, and Nyxoah expects to submit its responses to Inspire's filings on or before the deadline of March 31, 2026.

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The outcome of these matters are inherently uncertain, and there can be no assurances that a favorable outcome will be obtained. Regardless of outcome, litigation can have an adverse impact on us due to defense and settlement costs, diversion of management resources, negative publicity and reputational harm, among other factors.

**C.**Organizational Structure

The following is a list of our significant subsidiaries:

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| | | | |
|:---|:---|:---|:---|
| <br>**Name of undertaking** | **Country of**<br>**registration** | <br>**Activity** | **Percent**<br>**holding** |
| Nyxoah Ltd | Israel | Medical Technology support and administrative activities | 100 |
| Nyxoah Pty Ltd | Australia | Medical Technology Research and Development | 100 |
| Nyxoah, Inc. | United States | Medical Technology Research and Development;<br>Commercialization of medical devices | 100 |
| Nyxoah GmbH | Germany | Commercialization of medical devices | 100 |

---

**D.**Property, Plant and Equipment

---

| | | | |
|:---|:---|:---|:---|
| **Type** | **Location** | **Size (square meters)** | **Expiry** |
| Executive office | Mont-Saint-Guibert, Belgium | 570 | June 30, 2029 |
| Offices | Milmort, Belgium | 120 | December 31, 2026 |
| Manufacturing | Milmort, Belgium | 140 | July 29, 2027 |
| Packaging | Milmort, Belgium | 40 | August 28, 2026 |
| Offices | Liège, Belgium | 212 | December 8, 2026 |
| Executive office/Storage | Tel Aviv, Israel | 1356 | June 30, 2026 |
| Offices | Summit, NJ, U.S.A. | 93 | August 31, 2026 |

---

All of our property is leased. We believe that our office facilities are sufficient to meet our current needs.

#### Facilities
We operate out of a leased site in Mont-Saint-Guibert, Belgium, which consists of 570 square meters (approximately 6,135 square feet) of office space and is our corporate headquarters and home to our European commercial, training and education, marketing, and clinical activities. The lease for the site in Mont-Saint-Guibert, Belgium expires on June 30, 2029.

We operate out of a leased site in Milmort, Belgium, which consists of 140 square meters (approximately 1,500 square feet) of manufacturing space (cleanroom), 40 square meters (approximately 430 square feet) of packaging space (cleanroom) and 120 square meters (approximately 1290 square feet) of office space and is home to our manufacturing activities. The lease for the office space in Milmort, Belgium expires on December 31, 2026. We can terminate the contract at any time with a notice period of six months. The lease for the manufacturing space in Milmort, Belgium was for an indefinite duration, and notice of termination has been given effective as of January 29, 2026, with a notice period of eighteen months. The lease for the packaging space expires on February 28, 2026, and will be renewed for at least an additional six months. In addition, we entered into an office lease agreement effective December 8, 2025, covering 212 square meters (approximately 2,280 square feet) of office space in Liège, Belgium. This office lease has an initial term of one year and is subject to automatic annual renewal unless terminated by either party with at least one month's prior written notice.

Nyxoah Ltd operates out of a leased site in Tel Aviv, Israel, which consists of 1,306 square meters (approximately 11,830 square feet) of office space and 50 square meters (approximately 540 square feet) of additional storage space. Until December 31, 2025, this leased site was home to our research and development and manufacturing activities. Since then, it is home to certain supporting activities. The lease for the site in Tel Aviv, Israel expires on June 30, 2026.

Nyxoah Inc. operates out of a leased site in Summit, New Jersey, U.S.A., which consists of 93 square meters (approximately 1,000 square feet) of office space. The lease for the office space in Summit, New Jersey expires on August 31, 2026.

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#### Item 4A. Unresolved Staff Comments
None.

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| | |
|:---|:---|
| **Item 5.** | **Operating and Financial Review and Prospects** |

---

You should read the following discussion and analysis of financial condition and operating results together with the information in "Selected Consolidated Financial Data" and our consolidated financial statements and the related notes to those statements included elsewhere in this Annual Report. We present our consolidated financial statements in EUR and in accordance with International Financial Reporting Standards, or IFRS, as issued by the International Accounting Standards Board, or IASB, which may differ in material respects from generally accepted accounting principles in other jurisdictions, including generally accepted accounting principles in the United States, or U.S. GAAP.

The statements in this discussion regarding industry outlook, our expectations regarding our future performance, liquidity and capital resources and other non-historical statements are forward-looking statements. These forward-looking statements are subject to numerous risks and uncertainties, including the risks and uncertainties described in the section titled "Risk Factors." Our actual results may differ materially from those contained in or implied by any forward-looking statements.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A. **Operating Results** 

#### Overview
We are a medical technology company focused on the development and commercialization of innovative solutions to treat OSA. Our lead solution is the Genio system, a CE-Marked, patient-centric, minimally invasive, next generation hypoglossal neurostimulation therapy for the treatment of moderate to severe OSA. OSA is the world's most common sleep disordered breathing condition and is associated with increased mortality risk and comorbidities including cardiovascular diseases, depression and stroke. Our innovative technology platform is a first-of-its-kind hypoglossal nerve stimulation device designed to treat OSA through bilateral stimulation, by maintaining an open airway for a restful night's sleep. We started generating revenue from the sale of the Genio system in Europe in July 2020, and during first quarter of 2023 began enrollment in the DREAM trial designed to support marketing authorization in the United States was completed.. We announced on March 19, 2024 that the DREAM pivotal trial has achieved its primary endpoints. We filed the fourth and final module of the modular premarket approval (PMA) application at the end of the second quarter 2024 and received FDA approval on August 8, 2025.

To date, our primary sources of capital have been private placements and public offerings of our common stock, debt financing agreements, and revenue from the sale of our products. Since inception, we have raised equity financing of €332.5 million. As of December 31, 2025, we had cash and cash equivalents of €30.0 million and financial assets of €18.0 million, long-term debt of €19.0 million and an accumulated deficit of €306.0 million. This raises, however, a substantial doubt in respect of going concern as the current funds are not sufficient to cover a period of 12 months following the date of the Annual Report. We have devoted substantially all our resources to activities supporting the Genio system, including continued research and development and regulatory initiatives, and during 2025 we significantly expanded our commercialization infrastructure, particularly in the United States, following FDA approval. During the year ended December 31, 2025 we generated revenue of €10.0 million and our net loss was €90.0 million. We expect that our research and development and selling, general and administrative and other expenses will continue to increase as we expand our marketing efforts to increase sales of the Genio system, conduct clinical trials, seek additional regulatory approvals and clearances and continue to invest in research and development to create product enhancements and enhance our product offering.

#### Key Factors and Trends

#### Obtaining regulatory approval in additional significant markets
We must successfully obtain timely approval or clearances and introduce new markets that gain acceptance with physicians. We are currently approved to market in Europe and in the United States. Our ability to expand the list of countries in which we can market and sell our system will impact our revenue growth and the costs we incur in anticipation of such growth. Seeking for and obtaining regulatory approval for the Genio system in any additional countries is a long, expensive and uncertain process that can be impacted by numerous risks which are outside our control.

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#### Growing and supporting our commercial organization.
***We are committed to making additional investments in, and will continue to invest in recruiting, training and retaining experience and specialized sales teams. As of December 31, 2025, our European training, commercial and marketing team consists of twenty-eight professionals, who have substantial medical device sales and marketing, training and education as well as clinical experience and are operating from our headquarters in Belgium as well as from Germany and the UK. Since the Genio system began being reimbursed under a dedicated DRG code in Germany, we have additionally invested in building up a dedicated direct sales and marketing organization of ten individuals, led by a country director in Germany. Once the Genio system began being reimbursed in the United Kingdom via the NHS Specialised Services Devices Programme (SSDP), we hired a direct sales and marketing organization of four individuals, led by a country director. We have also contracted with select distributors in the Middle East to sell products to hospitals in the select markets such as the UAE and Kuwait.***

***In advance of PMA approval in the United States, we hired a direct sales and marketing organization of over 50 people, of which 25 were sales representatives. Our sales strategy in the United States, which represents the largest market in the world for hypoglossal nerve stimulation (HGNS), is to focus on the top 400 HGNS accounts which represent over 70% of the total HGNS volume. Each of our sales representatives can cover 4 to 6 of the top 400 HGNS accounts. We expect to hire new sales representatives in cohorts of 15 and, over time, we expect to hire 85 sales representatives in total to cover the top 400 HGNS accounts in the United States per sales representative. In the first quarter of productivity, the fourth quarter of 2025, our initial class of 25 sales representatives generated on average $700,000 in annualized revenue in the United States, For the full year 2026, we expect that this initial class of 25 sales representatives will generate on average $1.0 million to $1.2 million in annual revenue per sales representative, and at full productivity, we expect a sales representative to generate over $2.0 million per year in revenue.***

***In order to grow our business with existing and new accounts, we will need to continue making significant investments in educating physicians, hospitals and patients in the advantages of the Genio system for the treatment of moderate to severe OSA.***

#### Continuing to invest in developing clinical support.
Publication of clinical results by us can have a significant influence on whether the Genio system is used by physicians. We intend to continue investing in clinical studies on the Genio system. We are initially targeting markets in Europe and the United States where we have identified a country-specific reimbursement pathway or execution strategy. We obtained reimbursement coverage and began marketing in Germany in 2020 and Switzerland in 2021. We generated our first revenue in Spain in 2021 through local funding and we began commercialization in Finland in 2022. We generated our first revenue in Austria in 2023. We generated our first revenue in the United Kingdom in 2024 and our first revenue in the United States in 2025.

#### Increasing physician adoption and acceptance of the Genio System
The growth of our business depends on our ability to gain broader acceptance of the Genio system by continuing to make physicians aware of the benefits of the Genio system in order to generate increased demand and frequency of use and, thus, increase sales to our customers. Our ability to grow our business will also depend on our ability to expand our customer base in existing and new target markets. To date, the Genio system is our only product on the market.

#### Securing additional coverage and reimbursement by third-party payors
The level of reimbursement from third-party payors for procedures performed using the Genio system could have a substantial impact on the prices we are able to charge for the Genio system and how widely it is accepted. In many countries, payment for the Genio system will be dependent on obtaining a reimbursement code or codes for the procedure and the Genio system. Obtaining a reimbursement code can be a lengthy process that varies from country to country. While there is general consensus among physicians and payors of the medical necessity to treat OSA and increase the number of hypoglossal nerve stimulation therapy coverage decisions, we continue to develop further clinical evidence demonstrating a long-term meaningful improvement in net health outcomes for patients meeting the specified criteria. We believe that establishing and maintaining reimbursement will be important in achieving broad acceptance of our system by healthcare providers in these markets.

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#### Continuing to invest in innovation and growth
We continue to invest in, and innovate with respect to, our existing Genio system to further improve future generations, as well as clinical outcomes, enhance the patient and physician experience and broaden the patient population that can be treated. We are also investing in building our pipeline of new products through our partnership with Vanderbilt University to expand the current neurostimulation options to treat moderate to severe OSA. While developing new products and technologies can be time consuming and costly, we believe that a pipeline of new technologies and next generation products is important for supporting increased adoption of our products and improving our gross margin profile. Through these investments in new products and innovation, we will be able to increase our gross margin to over 80% once we achieve appropriate scale. In the short term, we expect these activities to increase our net losses, but in the longer term, we anticipate they will positively impact our business, improve our gross margin and results of operations.

Due to these and other factors and trends, we expect to experience meaningful variability in our financial performance for the foreseeable future, including, but not limited to: costs, benefits and timing of new product introductions; the availability and cost of components and raw materials; and fluctuations in foreign currency exchange rates. Additionally, we may experience quarters in which operating expenses, in particular research and development expenses, fluctuate depending on the stage and timing of product development.

While these factors may present significant opportunities for us, they also pose significant risks and challenges that we must address. See the section titled "Risk Factors" for more information.

***Need for additional capital***

We expect to incur significant expenses and operating losses over the next few years, and we may need to raise additional capital in the future. We have so far been financed primarily by funds invested by our shareholders, including in connection with our initial public offering on Euronext Brussels in September 2020 and the listing of our ordinary shares on the Nasdaq Global Market in July 2021. Based on our current operating plan and our existing cash and cash equivalents of €30.0 million and financial assets of €18.0 million as of December 31, 2025, we expect to be able to fund our operations through the middle of 2026 with an extension into early 2027 should we draw down the second tranche of the EIB term debt facility and the second tranche of the convertible debt facility. However, we have based these estimates on assumptions that may prove to be incorrect, and we could spend our financial resources much faster than currently expected. Our ability to continue as a going concern will depend on our ability to obtain additional funding, as to which no assurances can be given. To fund the business to profitability, we will need to raise €110 million in additional capital. We expect to be profitable, as measured as positive Adjusted EBITDA, once we reach €150 million in annual revenue. Pursuant to the requirements of IAS 1.25-26, Presentation of Financial Statements - Going Concern, and as a result of our financial condition and other factors described herein, there is substantial doubt about our ability to continue as a going concern for a period of at least twelve months from the date of this Annual Report. See the report of our independent registered public accounting firm and Note 5.1 to our consolidated financial statements found elsewhere in this Annual Report. Our ability to continue as a going concern will depend on our ability to obtain additional funding, as to which no assurances can be given. See "Risk Factors— Risks Related to Our Financial Position— We will require additional capital in the future, which may not be available to us on commercially favorable terms, or at all. More specifically, there is substantial doubt about our ability to continue as a going concern for a period of at least twelve months from the date of this Annual Report and our ability to continue as a going concern will depend on our ability to obtain additional funding, as to which no assurances can be given as of the date of this Annual Report."

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#### Financial Operations Overview

#### Revenue
We currently derive all of our revenue from the sale of our proprietary Genio system. We sell the Genio system to both hospitals and distributors. Revenue is recognized based on the satisfaction of performance obligations identified in customer contracts. Performance obligations are satisfied when control of the Genio® system is transferred to the customer, either upon shipment or delivery, depending on contractual terms. The revenue related to the first performance obligation (i.e. shipment or delivery of the Genio® system implants) is recognized at a point in time. Due to the start of the commercialization in the United States, certain patient-related components are supplied after the initial shipment. In this case, a portion of the transaction price is allocated to this future delivery, with revenue deferred and recognized at a point in time upon delivery. Moreover, as from 2024, the Company has identified a separate performance obligation related to the replenishment of additional disposable patches beyond the initial shipment. A portion of the transaction price is allocated to these future deliveries, with revenue deferred and recognized over time upon transfer of control.

***The contract liability included in the consolidated balance sheet is related to revenue attributed to the additional replenishment of disposable patches which is recognized when control of the patches is transferred to the customer or patient quarterly following the patient implants and the revenue attributed to the future deliveries of the patient-related components in the United States. Per December 31, 2025, the current contract liability amounts to €0.9 million while the non-current contract liability amounts to €0.7 million. Per December 31, 2024, the current contract liability amounts to €117,000 while the non-current contract liability amounts to €472,000.***

#### Cost of Goods Sold
***Cost of goods sold consists primarily of third-party manufacturing costs that we incur to obtain the components necessary to manufacture our Genio system. Direct costs from our third-party manufacturers include costs for raw materials plus the mark-up for the assembly of the components. Cost of goods sold also includes allocated overhead for direct and indirect labor, certain direct costs such as those incurred for shipping our products.***

#### Gross Profit and Gross Margin
We calculate gross profit as revenue less cost of goods sold, and gross margin as gross profit divided by revenue. Our gross margin has and will continue to be affected by a variety of factors, primarily average selling prices, production and ordering volumes, third-party manufacturing costs and cost-reduction strategies. We expect our gross profit to increase in the foreseeable future as our revenue grows. We expect our gross margin to increase over the long-term as we launch new products which cost less to manufacture, streamline our supply chain efforts, and as our production volume increases which will provide us with cost reductions and would spread our fixed manufacturing costs over a larger number of units.

#### Operating Expenses
*Research and Development Expenses (in aggregate)*

Research and development expenses consist primarily of product development, engineering to develop and support our products, testing, consulting services and other costs associated with the next generation of the Genio® system. These expenses primarily include employee compensation, consulting and contractor's fees and outsourced development expenses. We will continue to invest in research and development expenses as we develop the next generation of the Genio system, investing in building a new product pipeline and expect our research and development expenses (in aggregate) to decrease in the near-term given the closure of the Israel R&D department and reduced costs related to the EliSA, DREAM and ACCESS clinical studies.

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*Selling, General and Administrative (in aggregate)*

*General and Administrative Expenses*

General and administrative expenses consist primarily of compensation for personnel, including salaries, bonuses, benefits, and stock-based compensation, spending related to direct sale forces, market access and reimbursement activities to support the commercialization of Genio system in Europe and in the Unites States, consulting fees and spending related to finance, information technology, legal and human resource functions, as well as professional services fees (including legal, audit and tax fees), insurance costs, general corporate expenses and allocated facilities-related expenses to support the scale up of the Company. We expect that our selling, general and administrative expenses (in aggregate) will increase as commercial activities will increase in the United States and to support the scale up of the Company in legal, finance, tax and IT matters.

*Other Operating Income/Expenses*

Other operating income/expenses consist of the impact of the initial measurement and re-measurement of financial debt and the Australian R&D incentive subsidies receive by our subsidiary in Australia and as from 2023 the tax incentive in Belgium as well.

#### Results of Operations

#### Comparison of Year Ended December 31, 2024, and 2025
The following table summarizes our results of operations for the periods presented below:

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| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
|  | **For the Year Ended** | **For the Year Ended** | **For the Year Ended** | **For the Year Ended** | **Year-Over-Year** | **Year-Over-Year** | **Year-Over-Year** |
|  | **December 31,** | **December 31,** | **December 31,** | **December 31,** | **Change** | **Change** | **Change** |
| **(In Thousands)** | **2025** | **2025** | **2024** | **2024** | **Euro Change** | **Euro Change** | **% Change** |
| Revenue | € | 10020 | € | 4521 | € | 5499 | 122% |
| Cost of goods sold  |  | (3694) |  | (1552) |  | (2142) | 138% |
| **Gross Profit** |  | **6326** |  | **2969** |  | 3357 | 113% |
| &nbsp;&nbsp;Research and development expenses  |  | (42824) |  | (34325) |  | (8456) | 25% |
| General and administrative expenses |  | (48302) |  | (28461) |  | (22679) | 80% |
| Other operating income/(expenses) |  | 1315 |  | 1008 |  | 307 | 31% |
| **Operating loss for the period** |  | **(83485)** |  | **(58809)** |  | (27471) | 47% |
| Financial income |  | 5928 |  | 7447 |  | (1519) | 20% |
| Financial expense |  | (11519) |  | (5070) |  | (3296) | 65% |
| **Loss for the period before taxes**  |  | **(89076)** |  | **(56432)** |  | (32286) | 57% |
| Taxes |  | (1009) |  | (2804) |  | 1795 | 64% |
| **Loss for the period**  |  | **(90085)** |  | **(59236)** |  | (30491) | 52% |

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*Revenue*

Revenue was €10.0 million for the year ended December 31, 2025, compared to €4.5 million for the year ended December 31, 2024. In the fourth quarter of 2024, the Company began deferring the portion of the selling price allocated to disposable patches for the Genio system. The increase in revenue was driven by the continued expansion of our commercialization efforts, including the commencement of sales in the United States following FDA approval on August 8, 2025, and further growth in additional markets such as the Netherlands and the UAE.

*Cost of Goods Sold*

Cost of goods sold was €3.7 million for the year ended December 31, 2025, compared to €1.6 million for the year ended December 31, 2024. The increase in cost of goods sold was primarily driven by higher sales volumes resulting from the continued expansion of our commercialization efforts for the Genio system, including the commencement of sales in the U.S. following FDA approval and further growth in additional markets such as the Netherlands and the UAE.

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*Research and Development Expenses (in aggregate)*

*Research and development expenses* (in aggregate) increased by €8.5 million, or 26%, from €34.3 million in 2024 to €43.0 million in 2025 due to the factors discussed below with respect to each component of research and development expenses (in aggregate).

*Staff costs Expenses.* Staff costs increased by €1.4 million, or 11%, from €13.1 million in 2024 to €14.6 million in 2025, primarily driven by higher headcount and related personnel expenses to support our clinical, R&D and manufacturing activities.

*Consulting and Contractors' Fees Expenses.* Consulting and contractors' fees expenses increased by €3.5 million, or 55% from €6.5 million in 2024 to €10.0 million in 2025 due to an increase in consulting and contractors' fees to support our clinical, R&D and manufacturing activities.

*Depreciation and Amortization Expenses*. Depreciation and amortization expense increased by €1.7 million, or 121%, from €1.4 million in 2024 to €3.2 million in 2025, primarily due to the commencement of amortization of certain intangible assets following FDA approval in August 2025.

*Clinical Expenses.* Clinical expenses decreased by €1.1 million, or 18.4%, from € 6.1 million in 2024, to €5.0 million in 2025. The decrease in clinical study expenses was primarily driven by reduced clinical activity following the completion of enrollment in the ACCCESS and EliSA studies and the completion of the Usability study.

*Manufacturing and Outsourced Development Expenses.* Manufacturing and outsourced development expenses decreased by €0.5 million, or 6.0%, from €8.6 million in 2024 to €8.1 million in 2025 primarily due to the closure of our R&D activities in Israel in the second half of 2025, which reduced related outsourced development support costs.

*Training Expenses.* Training expenses increased primarily due to expanded training activities to support surgeon education and adoption of the Genio system.

*IT Expenses*. IT expenses decreased by €0.4 million, or 62%, from €0.6 million for the year ended December 31, 2024, to €0.2 million for the year ended December 31, 2025. The decrease is mainly due to the initiation of a new ERP implementation in 2023.

*Selling, General and Administrative Expenses (in aggregate)*

Selling, general and administrative expenses (in aggregate) increased by €19.8 million, or 70.0%, from €28.5 million in 2024 to €48.3 million in 2025 due to the factors discussed below with respect to each component of selling, general and administrative expenses (in aggregate).

*Staff Costs Expenses.* Staff costs expenses increased by €15.4 million, or 145.0%, from €10.7 million in 2024 to €26.1 million in 2025 mainly due to an increase in costs to support the commercialization of Genio® system and the Company's overall scale-up preparations for the commercialization of the Genio® system in the Unites States following receipt of FDA approval. 

*Consulting and Contractors' fees Expenses.* Consulting and contractors' fees expenses increased by €1.4 million, or 12.2%, from €11.1 million in 2024 to €12.5 million in 2025 mainly due to an increase in costs to support the commercialization of Genio® system and the Company's overall scale-up preparations for the commercialization of the Genio® system in the United States following receipt of FDA approval. Consulting and contractor fees also includes a provision for an amount of €0.7 million recognized under IAS 37 for the estimated future costs related to the replenishment of certain consumable components, reflecting a constructive obligation arising from business practices.

*Legal fees.* Legal fees increased primarily due to higher professional fees incurred to support the Company's financing and capital markets activities during the year.

*Recruitment Fees.* Recruitment expenses decreased by €0.6 million, or 79 %, from €0.7 million for the year ended December 31, 2024, to €0.2 million for the year ended December 31, 2025. The decrease is mainly due to lower recruitment activity in 2025.

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*Operating Loss* 

The increase in operating loss from €58.8 million in 2024 to €83.5 million in 2025, or a change of €24.7 million, was mainly due to increases in operating expenses to support the commercialization of the Genio system and the Company's scale-up for the U.S. market following FDA approval. The Company continues investing in research and development to improve and develop the next generation of the Genio system and preparing for scaling up production capacities.

***Comparison of Year Ended December 31, 2023, and 2024***

The following table summarizes our results of operations for the periods presented below:

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| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
|  | **For the Year Ended** | **For the Year Ended** | **For the Year Ended** | **For the Year Ended** | **Year-Over-Year** | **Year-Over-Year** | **Year-Over-Year** |
|  | **December 31,** | **December 31,** | **December 31,** | **December 31,** | **Change** | **Change** | **Change** |
| **(In Thousands)** | **2024** | **2024** | **2023** | **2023** | **Euro Change** | **Euro Change** | **% Change** |
| Revenue | € | 4521 | € | 4348 | € | 173 | 4% |
| Cost of goods sold  |  | (1552) |  | (1656) |  | (104) | 6% |
| **Gross Profit** |  | **2969** |  | **2692** |  | 277 | 10% |
| &nbsp;&nbsp;Research and development expenses |  | (34325) |  | (26651) |  | (7674) | 29% |
| General and administrative expenses |  | (28461) |  | (21687) |  | (6774) | 31% |
| Other operating income/(expenses) |  | 1008 |  | 544 |  | 464 | 85% |
| **Operating loss for the period** |  | **(58809)** |  | **(45102)** |  | (13707) | 30% |
| Financial income |  | 7447 |  | 4174 |  | 3273 | 78% |
| Financial expense |  | (5070) |  | (3729) |  | (1341) | 36% |
| **Loss for the period before taxes**  |  | **(56432)** |  | **(44657)** |  | (11775) | 26% |
| Taxes |  | (2804) |  | 1445 |  | (4249) | 294% |
| **Loss for the period**  |  | **(59236)** |  | **(43212)** |  | (16024) | 37% |

---

*Revenue*

Revenue was €4.5 million for the year ended December 31, 2024, compared to €4.3 million for the year ended December 31, 2023. In the fourth quarter of 2024, the Company began recording a portion of the selling price for a Genio system related to disposable patches as deferred revenue and recognized €0.6 million in the quarter. The increase in revenue was attributable to our growing commercialization of the Genio system, including in additional markets, such as Italy and UK.

*Cost of Goods Sold*

Cost of goods sold was €1.6 million for the year ended December 31, 2024, compared to €1.7 million for the year ended December 31, 2023. The increase in cost of goods sold was attributable to our growing commercialization of the Genio system, including in additional markets, such Italy and UK.

*Research and Development Expenses (in aggregate)*

*Research and development expenses* (in aggregate) increased by €7.6 million, or 29%, from €26.7 million in 2023 to €34.3 million in 2024 due to the factors discussed below with respect to each component of research and development expenses (in aggregate).

*Staff costs Expenses.* Staff costs decreased by €0.7 million, or 5%, from €13.8 million in 2023 to €13.1 million in 2024, primarily due to a reduction in headcount resulting from the scaling down of manufacturing and engineering activities in Israel.

*Consulting and Contractors' Fees Expenses.* Consulting and contractors' fees expenses increased by €3.7 million, or 134% from 2.8 million in 2023 to €6.5 million in 2024 due to an increase in consulting and contractors' fees to support our clinical, R&D and manufacturing activities.

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*Clinical Expenses.* Clinical expenses increased by €1.2 million, or 23.8%, from €4.9 million in 2023, to €6.1 million in 2024. The increase in clinical expense was mainly due to an increase in ACCCESS and Usability decrease in clinical study activities due to finalizing enrollment of DREAM Study.

*Manufacturing and Outsourced Development Expenses*. Manufacturing and outsourced development expenses increased by €2.1 million, or 32.9%, from €6.5 million in 2023 in 2022 to €8.6 million in 2024 due to an increase in manufacturing and outsourced development expenses to support our clinical, R&D and manufacturing activities.

*IP Costs Expenses.* Legal fee expenses decreased by €0.9 million, or 95.3%, from €0.9 million for the year ended December 31, 2023, to €0.0 million for the year ended December 31, 2024. The decrease is mainly due to the payment for in-licensing agreement with Vanderbilt University during 2023.

*IT Expenses.* IT expenses decreased by €1.2 million, or 65%, from €1.8 million for the year ended December 31, 2023, to €0.6 million for the year ended December 31, 2024. The decrease is mainly due to the initiation of a new ERP implementation in 2023.

*Selling, General and Administrative Expenses (in aggregate)*

Selling, general and administrative expenses (in aggregate) increased by €6.8 million, or 31.3%, from €21.7 million in 2023 to €28.5 million in 2024 due to the factors discussed below with respect to each component of selling, general and administrative expenses (in aggregate).

*Staff Costs Expenses.* Staff costs expenses increased by €2.0 million, or 22%, from €8.7 million in 2023 to €10.7 million in 2024 mainly due to an increase in staff costs to support commercialization of Genio system in Europe and scale up of the Company.

*Consulting and Contractors' fees Expenses.* Consulting and contractors' fees expenses increased by €4.3 million, or 63.2%, from €6.8 million in 2023 to €11.1 million in 2024 mainly due mainly due to an increase in consulting and contractors' fees costs to support commercialization of Genio system in Europe and scale up of the Company. As from 2024, consulting and contractor fees also include a provision in the amount of €0.7 million recognized under IAS 37 for the estimated future costs related to the replenishment of certain consumable components, reflecting a constructive obligation arising from business practices.

*Insurance Fees Expenses.* Insurance fees expenses decreased by €0.5 million, or 48%, from €1.0 million for the year ended December 31, 2023, to €0.5 million for the year ended December 31, 2024. The insurances fees expenses decreased mainly due to renegotiation of terms.

*Recruitment Fees.* Recruitment fees expenses increased by €0.5 million, or 258 %, from €0.2 million for the year ended December 31, 2023, to €0.7 million for the year ended December 31, 2024. The increase is mainly due to increase in staff to support commercialization of Genio system in Europe and scale up of the Company.

*Operating Loss*

The increase in operating loss from €45.1 million in 2023 to €58.8 million in 2024, or a change of €13.7 million, was mainly due to increases in operating expenses. We were conducting four clinical trials to continue gathering clinical data and obtain regulatory approvals. The Company continues investing in research and development to improve and develop the next generation of the Genio system and preparing for scaling up production capacities.

#### Recently Issued Accounting Pronouncements
We applied for the first-time certain interpretations and amendments, which are effective for annual periods beginning on or before January 1, 2024. The new standards and amendments that apply for the first time in 2024 are not expected to have a material impact on our financial position, results of operations or cash flows and are described in Note 2.2 to our consolidated financial statements found elsewhere in this Annual Report.

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#### Emerging Growth Company and Foreign Private Issuer Status

#### Emerging Growth Company Status
As a company with an annual revenue under $1.235 billion, we qualify as an "emerging growth company" as defined in the JOBS Act. As an emerging growth company, we may take advantage of specified reduced disclosure and other requirements that are otherwise applicable generally to public companies.

These provisions include:

● the ability to present only two years of audited financial statements in addition to any required interim financial statements and correspondingly reduced disclosure in management's discussion and analysis of financial condition and results of operations in this Annual Report;

● exemption from the auditor attestation requirement of Section 404 of the Sarbanes-Oxley Act of 2002, or the Sarbanes-Oxley Act, in the assessment of our internal controls over financial reporting; and

● to the extent that we no longer qualify as a foreign private issuer, (i) reduced disclosure obligations regarding executive compensation in our periodic reports and proxy statements and (ii) exemptions from the requirements of holding a non-binding advisory vote on executive compensation, including golden parachute compensation.

We may take advantage of these exemptions for up to five years or until such earlier time that we are no longer an emerging growth company. We will cease to be an emerging growth company upon the earliest to occur of (i) the last day of the fiscal year in which we have more than $1.235 billion in annual revenue; (ii) the date we qualify as a "large accelerated filer" with at least $700 million of equity securities held by non-affiliates; (iii) the issuance, in any three-year period by our company of more than $1.0 billion in non-convertible debt securities held by non-affiliates; and (iv) the last day of the fiscal year ending after the fifth anniversary of this public offering of our ordinary shares.

We may choose to take advantage of some but not all of these reduced burdens. For example, we intend to take advantage of the exemption from the auditor attestation on the effectiveness of our internal control over financial reporting. Accordingly, the information that we provide shareholders may be different than you might obtain from other public companies.

In addition, Section 107 of the JOBS Act provides that an emerging growth company can use the extended transition period provided in Section 7(a)(2)(B) of the Securities Act for complying with new or revised accounting standards. Given that we currently report and expect to continue to report under IFRS as issued by the IASB, we have irrevocably elected not to avail ourselves of this extended transition period and, as a result, we will adopt new or revised accounting standards on the relevant dates on which adoption of such standards is required by the IASB. Since IFRS makes no distinction between public and private companies for purposes of compliance with new or revised accounting standards, the requirements for our compliance as a private company and as a public company are the same.

#### Foreign Private Issuer Status
We currently report under the Exchange Act as a non-U.S. company with foreign private issuer status. Even after we no longer qualify as an emerging growth company, as long as we qualify as a foreign private issuer under the Exchange Act, we will be exempt from certain provisions of the Exchange Act that are applicable to U.S. domestic public companies, including:

● the sections of the Exchange Act regulating the solicitation of proxies, consents or authorizations in respect of a security registered under the Exchange Act;

● the sections of the Exchange Act requiring insiders to file public reports of their stock ownership and trading activities and liability for insiders who profit from trades made in a short period of time;

● the rules under the Exchange Act requiring the filing with the SEC of quarterly reports on Form 10-Q containing unaudited financial and other specified information, or current reports on Form 8 - K, upon the occurrence of specified significant events; and

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● Regulation FD, which regulates selective disclosures of material information by issuers.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;B. **Liquidity and Capital Resources** 

#### Overview
To date, our primary sources of capital have been private placements and public offerings of our common stock and debt financing agreements. Since inception, we have raised equity financing of €310.6 million. In September 2020, we raised €103.6 million as a result of the initial public offering of new shares on the Euronext. All of our shares were admitted to trading on the regulated market of Euronext Brussels under the symbol "NYXH". In July 2021, we raised €75.0 million net of transaction costs as a result of the initial public offering of new shares on The Nasdaq Global Market. In December 2022, we entered into an "at-the-market", or ATM, sales agreement with Cantor Fitzgerald & Co. ("Cantor") pursuant to which we may sell from time to time ordinary shares having an aggregate offering price of up to $50.0 million through Cantor, acting as our sales agent, of which $32.8 million of ordinary shares have been sold pursuant to the ATM program as of December 31, 2024. Sales of our ordinary shares pursuant to this ATM program are subject to certain conditions specified in the sales agreement. Sales under the ATM program are registered on a shelf registration statement on From F-3 that we filed with the SEC in December 2022, and which permits the offering, issuance and sale by us of up to a maximum aggregate offering price of $200.0 million of our securities, inclusive of our ordinary shares sold under the ATM program. In addition, we intend to file a new shelf registration statement on Form F-3 on March 20, 2025, to register the offer and sale by us of up to $200.0 million of our securities, inclusive of up to an additional $50.0 million of our ordinary shares under a new ATM program pursuant to the sales agreement with Cantor. During 2023 we carried out several capital raises for a total amount of €18.9 million. During 2024 we carried out additional capital raises for a total amount of €110.6 million. During 2025 we carried out additional capital raises for a total amount of €21.9 million. As of December 31, 2025, we had cash and cash equivalents of €30.0 million and financial assets of €18.0 million and an accumulated deficit of €305.6 million. Based on cash flow forecasts for the upcoming years, which include significant expenses and cash outflows in relation to -among others- the ongoing clinical trials, the continuation of research and development projects, and the scaling-up of the Company's manufacturing facilities, in support of the Company's commercial launch of its Genio product in the United States, there is a substantial doubt in respect of going concern as the current funds are not sufficient to cover a period of 12 months following the date of the Annual Report. See the report of our independent registered public accounting firm and Note 5.1 to our consolidated financial statements found elsewhere in this Annual Report.

#### Cash Flows
The following table summarizes the results of our cash flows for the years ended December 31, 2024 and 2025.

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **Year ended December 31,**  | **Year ended December 31,**  | **Year ended December 31,**  | **Year ended December 31,**  |
|  | **2025** | **2025** | **2024** | **2024** |
|  | **(In thousands)** | **(In thousands)** | **(In thousands)** | **(In thousands)** |
| Net cash used in operating activities | € | (68979) | € | (49226) |
| Net cash from (used in) investing activities |  | 28332 |  | (16325) |
| Net cash from (used in) financing activities |  | 38107 |  | 77439 |
| Effects of exchange rate changes |  | 1645 |  | 688 |
| **Change in cash and cash equivalents** | **€** | **(895)** | **€** | **12576** |

---

*Operating activities.* Net cash used in operations was €69.0 million in 2025 compared to €49.2 million in 2024. The increase in cash used in operations of €19.8 million was primarily due to higher losses of €32.3 million that were mainly attributable to increased research and development expenses and selling general and administrative general expenses, as described in more detail above. This increase was offset by a negative variation in the working capital and other non-cash adjustments.

*Investing activities.* Net cash used in investing activities was €28.3 million in 2025 compared to €16.3 million net cash from investing activities in 2024. The change of €45.0 million compared to 2024 is mainly due to a decrease in the purchase of term accounts by €56.0 million and a decrease in term accounts that reached their maturity by €13.3 million (after which the term deposit is held as cash. The cash outflow includes €3.0 million of investments in intangible assets primarily related to development activities, and €0.8 million of purchases of property, plant and equipment to support operational infrastructure

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*Financing activities.* Net cash from financing activities in 2025, was €38.1 million compared to €77.4 million in 2024. The increase was primarily derived from several capital increases during 2025. See Note 16 and 18 to our consolidated financial statements found elsewhere in this Annual Report.

The following table summarizes the results of our cash flows for the years ended December 31, 2023 and 2024.

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **Year ended December 31,**  | **Year ended December 31,**  | **Year ended December 31,**  | **Year ended December 31,**  |
|  | **2024** | **2024** | **2023** | **2023** |
|  | **(In thousands)** | **(In thousands)** | **(In thousands)** | **(In thousands)** |
| Net cash used in operating activities | € | (49226) | € | (44778) |
| Net cash from (used in) investing activities |  | (16325) |  | 32011 |
| Net cash from (used in) financing activities |  | 77439 |  | 16858 |
| Effects of exchange rate changes |  | 688 |  | (369) |
| **Change in cash and cash equivalents** | **€** | **12576** | **€** | **3722** |

---

*Operating activities.* Net cash used in operations was €49.2 million in 2024 compared to €44.8 million in 2023. The increase in cash used in operations of €4.4 was primarily due to higher losses of €11.8 million that were mainly attributable to increased research and development expenses and selling, general and administrative general expenses, as described in more detail above. This increase was offset by a negative variation in the working capital and other non-cash adjustments.

*Investing activities.* Net cash used in investing activities was €16.3 million in 2024 compared to €32.0 million of net cash from investing activities in 2023. The change of €48.3 million compared to 2023 is mainly due to an increase in the purchase of term accounts by €17.9 million and a decrease in term accounts that reached their maturity by €35.4 million (after which the term deposit is held as cash).

*Financing activities.* Net cash from financing activities in 2024, was €77.4 million compared to €16.9 million in 2023. The increase was primarily derived from several capital increases during 2024. See Note 15 to our consolidated financial statements found elsewhere in this Annual Report.

#### Operating and Capital Expenditure Requirements
We use our cash to fund our operations, which primarily include the cost of manufacturing our Genio system, as well operating expenses and related personnel costs. We expect research and development expenses to decrease in the near-term given the closure of the Israel R&D department and reduced costs related to the EliSA, DREAM and ACCESS clinical studies. In addition, we expect our selling, general and administrative expenses to increase for the foreseeable future as we hire personnel and expand our infrastructure to both drive and support the anticipated growth in our organization. We will also incur additional expenses as a result of operating as a dual listed public company and also expect to increase the size of our administrative function to support the growth of our business. The timing and amount of our operating expenditures will depend on many factors, including:

● acceptance of our therapy by patients, physicians, government payers, private payers, and the market generally;

● the scope, rate of progress and cost of current or future clinical studies;

● the cost of research and development activities;

● the cost associated with any complications or side effects related to the use of the Genio system;

● the cost of filing and prosecuting patent applications and other intellectual property rights and defending and enforcing our patents or other intellectual property rights in various jurisdictions;

● the cost of defending, in litigation or otherwise, any claims that we infringe third-party patents or other intellectual property rights;

● the cost and timing of additional regulatory clearances or approvals;

● the cost and timing of establishing additional sales and marketing capabilities;

● costs associated with any product recall that may occur;

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● the effect of competing technological and market developments;

● the extent to which we acquire or invest in products, technologies and businesses; and

● the costs of operating as a dual listed public company.

**We have consistently operated with deficits and sustained negative cash flows since our inception considering the significant research and development expenses incurred for the development and regulatory approval of the Genio device. As of December 31, 2025, our statement of financial position includes an accumulated loss of €305.6 million and total assets of €118.7 million. Current assets as of December 31, 2025 total €61.4 million, comprising €30.0 million in available cash and cash equivalents, and €18.0 million in marketable securities, primarily derived from previous public offerings.**

The Company expects to continue to incur operating losses and generate negative cash flows from operating activities, primarily due to continued investments supporting the U.S. commercial launch and the completion of its clinical trials, which are expected to be only partially offset by the Company's revenue generating activities. To meet the Company's future capital needs, management will continue to explore additional financing options, including the public or private issuance of equity and debt financing, as well as other funding alternatives. Taking into account the full convertible bond financing, as well as the second tranche under the Company's existing loan facility agreement with the European Investment Bank (for which the possibility to draw depends on a revenue milestone that the Company expects to meet in the first half of 2026), the Company's cash runway is expected to be extended into the first quarter of 2027, which means that we may not be able to fund our operations for at least 12 months as from the date of this Annual Report. Accordingly, this raises a substantial doubt in respect of going concern as the current funds are not sufficient to cover a period of 12 months following the date of the Annual Report. Nevertheless, the Board of Directors has decided that the application of the valuation rules in the assumption of a "going concern" is justified.

#### Contractual Obligations
The following table sets out our contractual obligations and commitments due by period as of December 31, 2025:

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **2025** | **2025** | **2025** | **2025** |
| **(in EUR 000)** | **Lease Liability** | **Lease Liability** | **Financial Debt** | **Trade & Other Liabilities** |
| **(in EUR 000)** |  |  |  |  |
| Less than 1 year |  | 812 | 702 | 15,493 |
| 1 - 5 years |  | 658 | 23,164 |  |
| 5+ years |  |  | 4,095 |  |
| **TOTAL** | **€** | **1,470** | **27,961** | **15,493** |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;C. **Research and Development, Patents and Licenses, etc.** 

Full details of our research and development activities and expenditures are given in "Item 4. Information on the Company–B. Business" and "Item 5A. Operating Results" within this Annual Report.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;D. **Trend Information** 

See "Item 5A. Operating Results" within this Annual Report.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;E. **Critical Accounting Estimates** 

See Note 5 to our consolidated financial statements found elsewhere in this Annual Report for a discussion on the critical accounting policies, estimates, assumptions, and judgments that we believe to have the most significant impact on our consolidated financial statements.

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#### Item 6. Directors, Senior Management and Employees
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A. **Directors and Senior Management** 

The following table sets forth the names, ages and positions of our executive officers and directors as of the date of this Annual Report:

---

| | | | |
|:---|:---|:---|:---|
| **Name** | **Age** | **Position** | **Term (1)** |
| *Executive Officers* |  |  |  |
| Olivier Taelman | 53 | Chief Executive Officer and Director |  |
| John Landry | 52 | Chief Financial Officer |  |
| Bruno Onkelinx | 53 | Chief Technology Officer |  |
| Scott Holstine | 54 | Chief Commercial Officer |  |
| *Non-Executive Directors* |  |  |  |
| Robelga SRL (represented by Robert Taub) | 76 | Non-Executive Director and Chairman | 2026 |
| Kevin Rakin | 64 | Non-Executive Director | 2026 |
| Pierre Gianello, M.D. | 68 | Non-Executive Director | 2026 |
| Jürgen Hambrecht, Ph.D. | 78 | Non-Executive Director | 2026 |
| Rita Johnson-Mills | 65 | Non-Executive Director | 2026 |
| Virginia Kirby | 69 | Non-Executive Director | 2026 |
| Wildman Ventures LLC (represented by Daniel Wildman) | 68 | Non-Executive Director | 2026 |

---

&nbsp;&nbsp;&nbsp;&nbsp;(1) The term of the mandates of the non-executive directors will expire immediately after the annual shareholders' meeting held in the year set forth next to the director's name.

#### Executive Officers
***Olivier Taelman*** has served as an executive director since September 2020 and our Chief Executive Officer since November 2019. Mr. Taelman joined our company in July 2019 as Chief Operating and Commercial Officer. Prior to joining our Company, Mr. Taelman was Vice President Europe at Autonomic Technologies, Inc., a U.S. medical device company, from December 2015 to June 2019, where he focused on clinical, market access and commercialization of SPG Neuromodulation to treat patients with severe headache and developed strong relationships with global key opinion leaders and managed investor relations. From November 2013 to December 2015, Mr. Taelman was Business Director, Neuromodulation at Nevro, Corp. (NYSE: NVRO) a neuromodulation company, where he was responsible for commercial operations in Europe and supported the company's transition from clinical-stage development to commercial operations. Prior to Nevro, Mr. Taelman held leadership positions at Stryker Corporation and Medtronic plc (NYSE: MDT), within their neurovascular and neuromodulation business for 10 years. Earlier in his career, Mr. Taelman held commercial roles at Sanofi-Aventis (NASDAQ: SNY) and Eli Lilly and Company (NYSE: LLY). Mr. Taelman holds an executive MBA from the Wharton University and a bachelor's degree in Biology and Physics from Hasselt University.

***John Landry*** has served as our Chief Financial Officer since November 2024. From July 2020 to October 2024, Mr. Landry served as the Senior Vice President, Chief Financial Officer, and Treasurer of Vapotherm Inc., and from August 2012 to July 2022, Mr. Landry served as Vapotherm Inc.'s Vice President, Chief Financial Officer, Secretary and Treasurer. Previously, Mr. Landry served as Director of International Marketing at Medtronic, Inc. from 2011 to 2012 following its acquisition in August 2011 of Salient Surgical Technologies, Inc., where Mr. Landry held certain leadership roles from 2004 to 2011, including VP Accounting & Controller and VP Global Business Development. Prior to his time at Salient Surgical Technologies, Inc., he served in various financial leadership roles at Bottomline Technologies from 2000 to 2004, Hussey Seating Company from 1997 to 2000 and Coopers & Lybrand LLP from 1994 to 1997. Mr. Landry currently serves on the board of directors of Liberate Medical, Inc. Mr. Landry graduated summa cum laude from Bentley College with a BS in Accountancy and is a certified public accountant (inactive status).

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***Bruno Onkelinx*** has served as our Chief Technology Officer since May 2021. Prior to joining Nyxoah, Mr. Onkelinx served as the Director of Incubation Operations at Cochlear from January 2020 to May 2021 where he was responsible for global incubation operations serving start-ups and scale-ups. Prior to serving as Director of Incubation Operations at Cochlear, Mr. Onkelinx also served as President of Cochlear Boulder (US), where he managed design and manufacturing for the organization, and Head of Acoustic Implant Development and Manufacturing at Cochlear, where he was responsible for global design and manufacturing activities for acoustic implants. Mr. Onkelinx received two Master's Degrees in Engineering and a postgraduate degree in Business Economics from KU Leuven in Leuven, Belgium.

***Scott Holstine*** has served as our Chief Commercial Officer since July 2024. Prior to joining Nyxoah, Mr. Holstine served as the Founder and Executive Director of Ibex Passage, a consulting firm, from July 2023 to June 2024 where he continues to serve as non-executive director in a non-operational role. From June 2021 to June 2023, Mr. Holstine served as President and General Manager of Teleflex Interventional, a global business focused primarily in interventional cardiology. Additionally, from June 2019 to May 2021, he served as General Manager of Amplifon sPa, where he was responsible for managing the Elite Hearing Network that focused on the otolaryngology and audiology market. Mr. Holstine received his MBA from the University of Minnesota, Carlson School of Management in Minneapolis, Minnesota and his BS from the United States Military Academy in West Point, New York.

#### Non-Executive Directors
***Robelga SRL,permanently represented by Robert Taub,*** has served as Chairman of our Board of Directors since June 2024. Mr. Taub is the founder of our company and served as Chairman of our Board of Directors since our inception in July 2009 to June 2024. He also served as our Chief Executive Officer from July 2009 to September 2016. Mr. Taub is an entrepreneur, investing in the pharmaceutical and medical fields. Prior to founding our Company, he co-founded and co-managed Octapharma AG, a human plasma protein company, from 1983 to 1995. He also founded and managed Omrix Biopharmaceuticals, Inc. through its initial public offering and listing on Nasdaq and its acquisition by Johnson & Johnson in 2008, and he brings decades of experience in life sciences, guiding companies from startup to global success. Mr. Taub holds an MBA from INSTEAD (Fontainebleau, France) and a BA in Languages from the University of Antwerp. Currently, Mr. Taub is the Chairman of Aya Gold and Silver (TSX: AYA.TO) and of Space Applications Services, a privately held space and defense company.

***Dr. Jürgen Hambrecht, Ph.D.*** served as a non-executive director from 2016 to 2017, and re-joined our Board of Directors in 2020. Dr. Hambrecht served BASF SE, a German company, in various responsibilities around the world for almost 45 years, lastly as CEO then Chairman of the Supervisory Board until 2020. He has been member of the Supervisory Boards of Daimler AG, Daimler Truck AG, Fuchs Petrolub SE, Trumpf SE, Bilfinger SE and Lufthansa AG a.o. Dr. Hambrecht is member of the Board of AYA Gold&Silver (TSX: AYA.TO) and of Blaize Holdings Inc (NASDAQ: BZAI). He earned his doctorate in Chemistry from the University of Tuebingen, Germany.

***Kevin Rakin*** has served as a non-executive director since June 2016. Since October 2013, Mr. Rakin has been a co-founder and partner of HighCape Capital and he brings more than 30 years of experience as an executive and investor in the life sciences industry. He served as the President of Shire Regenerative Medicine, Inc. from June 2011 to November 2012. Mr. Rakin was the chairman and chief executive officer of Advanced BioHealing from 2007 until its acquisition by Shire in 2011. Before that, he served as an Executive-in-Residence at Canaan Partners, a venture capital firm. Until its merger with Clinical Data in 2005, Mr. Rakin was the co-founder, President and Chief Executive Officer of Genaissance Pharmaceuticals, Inc., a pharmacogenomics company. He is currently on the boards of a number of private companies as well as Elutia, Inc. (NASDAQ: ELUT), where he serves as the chairman of the board and Quantum-Si (NASDAQ: QSI). Mr. Rakin received an MBA from Columbia University and a B.Com. (Hons) from the University of Cape Town, South Africa.

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***Rita Johnson-Mills*** has served as a non-executive director since August 2021. Since January 2018, Ms. Johnson-Mills has been a founder and Chief Executive Officer of consulting services firm RJM Enterprises and she brings a combined 30 years of direct health care experience from the federal, state and private industry, 15 years of which she was directly responsible for profitability and growth of healthcare organizations. Rita also currently serves as Senior Advisor for CINQCARE, a Washington, D.C.-based health and wellbeing organization. She served as President and Chief Executive Officer of UnitedHealthcare Community Plan of Tennessee from August 2014 to December 2017, after having previously served as Senior Vice President, Performance Excellence and Accountability for UnitedHealthcare Community & State since 2006. Before that, she served as the Director of Medicaid Managed Care for the Centers for Medicare and Medicaid Services and as Chief Executive Officer of Managed Health Services Indiana and Buckeye Health Plan, wholly owned subsidiaries of Centene Corporation. She currently serves on the Board of Directors of Accendra Health (formerly Owens & Minor, Inc.) and NACD – Nashville and previously served on the Board of Directors of Brookdale Senior Living Inc., Quest Analytics, LLC and Ellipsis Health Inc. Ms. Johnson-Mills received dual Master's degrees from Ohio State University, Master of Public Policy and Master of Labor/Human Resources. She is also a Hogan certified executive coach and a 2025 National Association of Corporate Directors, or NACD, Directorship100 honoree and recently achieved NACD Director Certification.

***Virginia Kirby*** has served as a non-executive director since June 8, 2022. Ms. Kirby is currently the Vice President of Global Regulatory and Clinical Affairs at xDot Medical, Inc, serving in this role since June 2024. Ms. Kirby is also a consultant with Virginia M. Kirby Consulting, a strategic consulting company that provides advisory services in clinical and regulatory strategy and operations, and has served in such role since April 2013. From March 2020 to January 2026, Ms. Kirby served as an Executive-in-Residence for the Office of Technology Commercialization at the University of Minnesota. Prior to these roles, she served as the Senior Vice President of Clinical and Regulatory Affairs for Huinno, Inc. from March 2016 to October 2017, the Vice President of Clinical and Regulatory Affairs at Apnex Medical, Inc. from 2007 to 2013, and the Vice President of Clinical Affairs and Reimbursement at both EnteroMedics, Inc. from 2005 to 2006, and at ev3, Inc. from 2003 to 2005. She also held various roles of increasing seniority at Medtronic, Inc. (NYSE: MDT) from 1997 to 2003, and at 3M Company (NYSE: MMM) from 1983 to 1996. Ms. Kirby currently serves as a member of the Board of Directors of the Minneapolis Heart Institute Foundation, a non-profit cardiovascular research and education foundation, and has served in such role since April 2021. Ms. Kirby received a Bachelor of Science degree in Speech and Hearing Science from the University of Minnesota, a Master of Science degree in Psychoacoustics/Audiology from Purdue University and a Master of Science degree in Management of Technology from the University of Minnesota, Carlson School of Management/Institute of Technology.

***Wildman Ventures LLC, permanently represented by Daniel Wildman,*** has served as a non-executive director since January 8, 2023. Mr. Wildman is currently the President and Chief Executive Officer of Wildman Ventures, LLC, a strategic consulting company that provides advisory services to several medical device and pharmaceutical companies, and has served in such role since January 2019. Additionally, Mr. Wildman is the Chairman of the Board of Progenerative Medical, Inc., where he has served in such role since March 2022, and is also an Independent Director for PanTher Therapeutics, Inc., where he has served in such role since February 2024. Prior to serving in such roles, Mr. Wildman served in various roles at Johnson & Johnson (NYSE: JNJ), or J&J, from 2000 to January 2019, where he most recently led the Digital Surgery Strategy Initiative that developed an integrated strategy for robotic surgery. From 1990 to 2000, Mr. Wildman served in a variety of sales, marketing, operations and strategic planning roles at Boston Scientific Corporation (NYSE: BSX). Mr. Wildman has served as a member of the Board of Directors of Urogen Pharma, Ltd. (NASDAQ: URGN) since November 2022 and previously served as an Independent Director of Precision Healing, Inc. from June 2020 to April 2022. Mr. Wildman received a Bachelor of Arts degree in Economics from St. Lawrence University.

***Pierre Gianello, M.D***. has served as a non-executive director since 2018, and as a medical advisor to the Company since 2010. From 2006 to 2022, Dr. Gianello was the general coordinator of Research of the Health Sciences Sector at the Université Catholique de Louvain, Brussels, or UCL, and from 2016 to 2022, he was the councilor of the vice-rector at the UCL. In 1997, Dr. Gianello became head of the Laboratory of Experimental Surgery and Transplantation at Université Catholique de Louvain and in 2005, he obtained the title of full Professor. From 2006 to 2009, he served as Dean of Research and from 2009 to 2011 as Vice-Rector. Professor Gianello has received ten scientific awards, including the Horlait-Dapsens Foundation (1986), Association "Professor Jean Morelle" Award (1989), "Claude Simon" Award (1989), Euroliver Foundation Prize (2001), Saint-Luc "Foundation" (2012). He is the author of more than 250 published manuscripts in peer reviewed scientific journals. Dr. Gianello was awarded a Doctor in Medicine, Surgery and Obstetrics at the Université Catholique de Louvain (Belgium), worked as a transplant surgeon at Clinic Saint Luc, Brussels and completed his post-doc training at the Massachusetts General Hospital, Harvard Medical School in the Transplant Biology Research Centre managed by Prof. David Sachs.

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#### Family Relationships
There are no family relationships among any of our executive officers or directors.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;B. **Compensation** 

The following discussion provides the amount of compensation paid, and benefits in kind granted, by us and our subsidiaries to our directors and members of management for services in all capacities to us and our subsidiaries for the year ended December 31, 2025, as well as the amount contributed by us or our subsidiaries into money purchase plans for the year ended December 31, 2025 to provide pension, retirement or similar benefits to, our directors and members of the executive management board.

#### Directors' and Executive Officers' Compensation

#### Directors' Compensation
Upon recommendation and proposal of the remuneration committee, our board of directors determines the remuneration of the directors to be proposed to the general shareholders' meeting.

Pursuant to Belgian law, the general shareholders' meeting approves the remuneration of the directors, including inter alia, each time as relevant:

&nbsp;&nbsp;&nbsp;&nbsp;(i) in relation to the remuneration of executive and non-executive directors, the exemption from the rule that share based awards can only vest after a period of at least three years as of the grant of the awards (Article 7:91, first subsection of the Belgian CCA);

&nbsp;&nbsp;&nbsp;&nbsp;(ii) in relation to the remuneration of executive directors, the exemption from the rule that (unless the variable remuneration is less than a quarter of the annual remuneration) at least one quarter of the variable remuneration must be based on performance criteria that have been determined in advance and that can be measured objectively over a period of at least two years and that at least another quarter of the variable remuneration must be based on performance criteria that have been determined in advance and that can be measured objectively over a period of at least three years (Article 7:91, second to fourth subsection of the Belgian CCA);

&nbsp;&nbsp;&nbsp;&nbsp;(iii) in relation to the remuneration of non-executive directors, any variable part of the remuneration (independent directors can never receive a variable remuneration) (Article 7:92, fourth and fifth subsection of the Belgian CCA); and

&nbsp;&nbsp;&nbsp;&nbsp;(iv) any provisions of service agreements to be entered into with executive directors providing for severance payments exceeding twelve months' remuneration and if the severance payments exceed eighteen months' remuneration, only with the prior recommendation of the remuneration committee (Article 7:92, first subsection of the Belgian CCA).

Notwithstanding points (i) and (ii) above, pursuant to our articles of association, our board of directors is explicitly authorized to deviate from the provisions of article 7:91 of the Belgian CCA.

The following annual remuneration and compensation of the directors applied for the year ended December 31, 2025:

---

| | |
|:---|:---|
|  | **Annual**<br>**Fixed Fee**<br>**(€)** |
| Chairman – Non-Executive Director | 82000 |
| Independent Director | 45000 |
| Non-Executive Director | 45000 |
| Additional fee for Audit Committee Member  | 9000 |
| Additional fee for Remuneration Committee Member  | 4500 |
| Additional fee for Science & Technology Committee Member | 4500 |
| Additional fee for Nominating and Corporate Governance Committee Member | 4500 |

---

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Additionally, for the year ended December 31, 2024, the chairman of the Audit Committee received remuneration and compensation at a rate equal to an annual fixed fee of €18,000, and the chairpersons of the Remuneration Committee, the Nomination and Corporate Governance Committee and the Science and Technology Committee received remuneration and compensation at a rate equal to an annual fixed fee of €9,000.

We also reimburse reasonable out-of-pocket expenses of directors (including travel and hotel expenses) incurred in performing the mandate of director.

Mr. Taelman, our chief executive officer and a member of our board of directors, does not receive any compensation for his service as a director. Additionally, there are no benefits upon the resignation of a director.

For the year ended December 31, 2025, the following remuneration or compensation (including reimbursement for out-of-pocket expenses) was due to the directors (excluding Olivier Taelman):

---

| | |
|:---|:---|
|  | **Fees Earned**<br>**(€)** |
| Robelga SRL (permanently represented by Robert Taub)  | 118562 |
| Kevin Rakin | 70688 |
| Pierre Gianello, M.D.(1) | 173177 |
| Jürgen Hambrecht, Ph.D. | 70917 |
| Rita Johnson-Mills | 70023 |
| Virginia Kirby  | 57740 |
| Wildman Ventures LLC (permanently represented by Daniel Wildman) | 81088 |

---

(1)Includes salary pursuant to an employment agreement with Pierre Gianello for the role of medical director one day per week.

In addition, in the year ended December 31, 2025, all non-executive directors were granted 20,933 restricted share units, or RSUs, whereby each RSU represents the obligation of the relevant non-executive director to subscribe for one new ordinary share of the Company at a subscription price of EUR 0.1718 per share (irrespective of the market value of the share at that time). The key features of the RSUs can be summarized as follows:

● Unless decided otherwise by the shareholders at our shareholders' meeting, whether for one, more or all non-executive directors, RSUs will be granted to non-executive directors on a yearly basis on the date of the annual shareholders' meeting.

● RSUs do not grant voting rights, preferential subscription rights or other membership rights.

● The number of RSUs to be granted on an annual basis shall be calculated as follows: €130,000 divided by the average closing price of our ordinary shares on the stock exchange where our shares are first listed, during the month of May of the year of the grant. For directors that are appointed between two annual shareholders' meetings, this number shall be prorated.

● RSUs are not transferable, except in case of death.

● RSUs in principle vest on the first anniversary of the date of grant provided that the relevant non-executive director is still in office at that time. In the event of death or an "exit", immediate vesting applies.

● The vesting of RSUs is not linked to any performance criteria but rather based on continued service during the vesting period. Therefore, the remuneration in RSUs is a form of fixed remuneration.

● The grant of RSUs to a non-executive director that has not been explicitly refused by the relevant non-executive director fifteen calendar days following the date of grant, shall be deemed accepted by the relevant non-executive director and creates an obligation for the relevant non-executive director to subscribe for the underlying shares when the RSUs have vested. The RSU is therefore not an option leaving discretion with the director whether to exercise or not.

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● The new shares to be issued pursuant to the exercise of RSUs shall be issued, subscribed, and fully paid up in principle within one month following the date of vesting of the relevant RSUs. The new shares shall be issued under our authorized capital. We reserve the right to deliver existing shares (if it has access to its own shares in accordance with applicable company law rules) or to compensate non-executive directors in cash (i.e., a cash amount equal to the closing stock price of the shares on the stock exchange where our shares are first listed on the first trading day following the date of vesting of the relevant RSUs, minus the subscription price of €0.1718 per share).

On August 26, 2025, each non-executive director received 14,806 newly issued ordinary shares following the exercise of the 14,806 RSUs at an exercise price of €0.1718 per ordinary share that were previously granted to each director in 2024.

The table below provides an overview as of December 31, 2025, of the warrants held by our non-executive directors.

---

| | | | |
|:---|:---|:---|:---|
|  | **Warrant Awards** | **Warrant Awards** | **Warrant Awards** |
|  | **Number of**<br>**Ordinary**<br>**Shares**<br>**Underlying**<br>**Warrants** | <br>**Warrant**<br>**Exercise Price**<br>**(€)** | <br>**Warrant**<br>**Expiration Date** |
| Robelga SRL | 25000 | 12.95 | June 8, 2027 |
| Robelga SRL | 25000 | 7.19 | June 14, 2028 |
| Kevin Rakin | 25000 | 12.95 | June 8, 2027 |
| Kevin Rakin | 25000 | 7.19 | June 14, 2028 |
| Pierre Gianello, M.D. | 25000 | 12.95 | June 8, 2027 |
| Pierre Gianello, M.D. | 25000 | 7.19 | June 14, 2028 |
| Jürgen Hambrecht, Ph.D. | 25000 | 12.95 | June 8, 2027 |
| Jürgen Hambrecht, Ph.D. | 25000 | 7.19 | June 14, 2028 |
| Rita Johnson-Mills | 25000 | 12.95 | June 8, 2027 |
| Rita Johnson-Mills | 25000 | 7.19 | June 14, 2028 |
| Virginia Kirby | 25000 | 12.95 | June 8, 2027 |
| Virginia Kirby | 25000 | 7.19 | June 14, 2028 |
| Wildman Ventures, LLC | 25000 | 7.19 | June 14, 2028 |

---

#### Executive Officers' Compensation
The remuneration of the chief executive officer and the other members of our executive management is based on recommendations made by our remuneration committee. The chief executive officer participates in the meetings of the remuneration committee in an advisory capacity each time the remuneration of another member of the executive management is being discussed.

The remuneration is determined by our board of directors, in accordance with our remuneration policy.

As an exception to the foregoing rule, Belgian law provides that the general shareholders' meeting must approve, as relevant:

&nbsp;&nbsp;&nbsp;&nbsp;(i) in relation to the remuneration of members of the executive management and other executives, an exemption from the rule that share-based awards can only vest after a period of at least three years as of the grant of the awards (Article 7:121, last subsection jo. Article 7:91, first subsection of the Belgian CCA);

&nbsp;&nbsp;&nbsp;&nbsp;(ii) in relation to the remuneration of members of the executive management and other executives, an exemption from the rule that (unless the variable remuneration is less than a quarter of the annual remuneration) at least one quarter of the variable remuneration must be based on performance criteria that have been determined in advance and that can be measured objectively over a period of at least two years and that at least another quarter of the variable remuneration must be based on performance criteria that have been determined in advance and that can be measured objectively over a period of at least three years (Article 7:121, last subsection jo. Article 7:91, second to fourth subsection of the Belgian CCA); and

Notwithstanding points (i) and (ii) above, our board of directors has been explicitly authorized in the Articles of Association to deviate from the provisions of Article 7:91 CCA.

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&nbsp;&nbsp;&nbsp;&nbsp;(iii) any service agreements to be entered into with members of the executive management and other executives (as the case may be) providing for severance payments exceeding twelve months' remuneration (or, subject to an opinion by the remuneration committee, eighteen months' remuneration) (Article 7:121, last subsection jo. Article 7:92, first subsection of the Belgian CCA).

An appropriate proportion of the remuneration package should be structured so as to link rewards to corporate and individual performance, thereby aligning the interest of the executive management with the interests of our shareholders. Our board of directors will determine whether the targets for the variable remuneration of the members of the executive management, as set by our board of directors, are met.

The remuneration of the executive management currently consists of the following main remuneration components:

● **Base remuneration**: annual base salary/fee (fixed);

● **Fringe benefits:** may include a company car or car allowance, laptop, phone, representation allowance and office allowance;

● **Age and risk provisions**: may include a pension plan with a fixed contribution and health insurance;

● **Short-term incentives:** includes a yearly performance bonus. If a target is reached, the member receives the full bonus, but if the target is not reached, they receive a proportionate payout; and

● **Long-term incentives**: includes participation in warrant incentive plans.

For the CEO, the target proportion of fixed base salary, short-term and long-term incentives is: one third fixed annual base remuneration, one third short-term incentives (if all targets are reached) and one third long-term incentives. For the other members of executive management, the target short-term variable remuneration is either set at a percentage of the fixed annual base remuneration (whereby that percentage can range from 30% to 100%) or set as a fixed amount (whereby that fixed amount would fall within said 30%-100% range).

The short-term variable remuneration (annual performance bonus in cash) of the members of executive management is based on company and/or individual performance. More precisely, the short-term variable remuneration of the members of executive management is based on the achievement of one or more Company objectives and/or one or more individual objectives. The Company objectives are established annually by the board of directors upon the advice of the remuneration committee. The individual objectives of the members of executive management are established annually by the board of directors upon the advice of the remuneration committee, whereby the Board of Directors can decide to delegate to the CEO the annual establishment of the individual objectives of all or some of the members of executive management.

Both the Company objectives and the individual objectives of the members of executive management are set in such a way that they are a challenge to be achieved. They relate to areas that are crucial for the Company to achieve its mission of becoming a global leader in providing innovative, clinically proven solutions to treat patients suffering from OSA, thereby contributing to the Company's business strategy, long-term interests and sustainability. Such areas can include: progress in research & development, clinical trial results, commercial milestones, corporate development, cash position, etc.

The assessment of whether and to what extent the Company objectives and the individual objectives of the members of executive management are achieved is established at the end of each year by the Board of Directors upon the recommendation of the remuneration committee, by comparing effective performance against the objectives. The Board of Directors can decide to delegate to the CEO the annual assessment of the achievement of the individual objectives of some or all of the members of executive management

[**Table of Contents**](#TOC)

The short-term and long-term incentives are detailed in the table below:

#### Short-term incentive plan: yearly performance bonus

---

| | |
|:---|:---|
| **Main provisions** | **Short description** |
|  | One or more performance criteria (objectives) are determined. For each performance criterion, a target and corresponding payout level are determined: <br>● If objective is 100% achieved: payout of targeted payout level<br>● If objective is achieved <100% or >100%: in principle, pro rata payout of targeted payout level, unless the Board decides otherwise<br>|
| **Calculation of bonus** | The total bonus is composed of the sum of the payout levels related to the various performance criteria (if more than one) |
| **Payment modalities** | Payment in cash or equivalent 100% of the bonus is paid at once |

---

#### Long-term incentive plan: share option plans

---

| | |
|:---|:---|
| **Main provisions** | **Short description** |
| Frequency of offer | No pre-set frequency |
| Performance cycle | NA |
| Target number of offered share options | NA |
| Exercise price | Value of underlying shares at date of offer of share options |
| Exercise period | Grants prior to August 2, 2024: five years from date of offer of share options<br>Grants as from August 2, 2024: ten years from date of issuance of share options |
| Performance criteria and corresponding offering levels | NA |
| Calculation of number of offered share options | NA |
| Vesting | Unless the Board of Directors determines otherwise, vesting in four tranches:<br>-1/4 of offered share options vests upon offer<br>-1/4 of offered share options vests on first anniversary of offer<br>-1/4 of offered share options vests on second anniversary of offer<br>-1/4 of offered share options vests on third anniversary of offer |
| Retention | NA |

---

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The following table sets forth information regarding compensation paid by us to Olivier Taelman, our chief executive officer, for the year ended December 31, 2025:

---

| | |
|:---|:---|
|  | **Compensation**<br>**(€)** |
| Base salary | 426991 |
| Performance bonus | 300000 |
| Pension contributions | 19860 |
| Fringe benefits(1) | 26139 |
| Extraordinary item | 100000 |

---

&nbsp;&nbsp;&nbsp;&nbsp;(1) Fringe benefits consist of company car, laptop and mobile phone, representation allowance, health insurance and meal vouchers.

In addition, in 2025, Mr. Taelman was granted 80,000 warrants under our 2024 Warrants Plan and 380,380 warrants under our 2025 Warrants Plan. In 2025, no warrants were forfeited. Upon termination of employment by the Company without cause within three months of a change of control, Mr. Taelman is entitled is entitled to an amount equal to up to 18 months of his then current salary.

The following table sets forth information regarding compensation paid by us to the other members of executive management on an aggregated basis. This includes compensation paid to John Landry, who served as our chief financial officer from January 1, 2025 to December 31, 2025, to Bruno Onkelinx, who served as our chief technology officer from January 1, 2025 to December 31, 2025, and to Scott Holstine, who served as our chief commercial officer from January 1, 2025 to December 31, 2025:

---

| | |
|:---|:---|
|  | **Compensation**<br>**(€)** |
| Base salary | 940092 |
| Performance bonus | 428.490 |
| Pension contributions | 15525 |
| Fringe benefits(1) | 59934 |
| Extraordinary item | 50000 |

---

&nbsp;&nbsp;&nbsp;&nbsp;(1) Fringe benefits consist of company car, laptop and mobile phone, representation allowance, health insurance, sectoral premium and eco-vouchers and meal vouchers.

In 2025, Mr. Landry was not granted any warrants. Upon termination of employment by the Company without cause, Mr. Landry is entitled to an amount equal to up to nine (9) months of his then-current salary. Additionally, upon termination of employment by the Company without cause within three months of a change of control, Mr. Landry is entitled is entitled to an amount equal to up to 18 months of his then current salary.

In addition, in 2025, Mr. Onkelinx was granted 10,000 warrants under our 2024 Warrants Plan and 15,000 warrants under our 2025 Warrants Plan. There are no benefits upon termination of employment.

In 2025, Mr. Holstine was not granted any warrants. There are no benefits upon termination of employment.

[**Table of Contents**](#TOC)

The table below provides an overview as of December 31, 2025 of the warrants held by the members of executive management:

---

| | | | |
|:---|:---|:---|:---|
|  | **Warrant Awards** | **Warrant Awards** | **Warrant Awards** |
|  | **Number of**<br>**Ordinary**<br>**Shares**<br>**Underlying**<br>**Warrants** | <br>**Warrant**<br>**Exercise Price**<br>**(€)** | <br>**Warrant**<br>**Expiration Date** |
| Olivier Taelman | 380,380 (2025 plan) | 4.92 | January 30, 2035 |
|  | 80,000 (2024 plan) | 9.63 | July 31, 2034 |
|  | 111,106 (2024 plan) | 7.88 | July 31, 2034 |
|  | 258,894 (2022 plan) | 7.88 | December 28, 2032 |
|  | 50,000 (2022 plan) | 5.24 | February 1, 2029 |
|  | 25,000 (2021 plan) | 5.42 | March 24, 2028 |
|  | 24,930 (2021 plan) | 5.42 | March 24, 2028 |
|  | 8,310 (2021 plan) | 25.31 | September 17, 2026 |
| John Landry | 300,000 (2024 plan) | 7.69 | July 31, 2034 |
| Bruno Onkelinx | 15,000 (2025 plan) | 4.92 | January 30, 2035 |
|  | 10,000 (2024 plan) | 9.63 | July 31, 2034 |
|  | 20,000 (2022 plan) | 5.24 | February 1, 2029 |
|  | 48,078 (2021 plan) | 5.24 | March 24, 2028 |
|  | 10,000 (2021 plan) | 17.76 | February 21, 2027 |
| Scott Holstine | 50,000 (2024 plan) | 7.88 | July 31, 2034 |

---

#### Insurance and Indemnification
Under Belgian law, the directors of a company may be liable for damages to our company in case of improper performance of their duties. Our directors may be liable to our company and to third parties for infringement of our articles of association or Belgian company law. Under certain circumstances, directors may be criminally liable. We maintain liability insurance for the benefit of our directors and members of our executive management team.

We maintain liability insurance for our directors and officers, including insurance against liability under the Securities Act of 1933, as amended, and we intend to enter into agreements with our directors and executive officers to provide contractual indemnification. With certain exceptions and subject to limitations on indemnification under Belgian law, these agreements will provide for indemnification for damages and expenses including, among other things, attorneys' fees, judgments, fines and settlement amounts incurred by any of these individuals in any action or proceeding arising out of his or her actions in that capacity.

These agreements may discourage shareholders from bringing a lawsuit against our directors and executive officers for breach of their fiduciary duty. These provisions also may have the effect of reducing the likelihood of derivative litigation against directors and executive officers, even though such an action, if successful, might otherwise benefit us and our shareholders. Furthermore, a shareholder's investment may be adversely affected to the extent we pay the costs of settlement and damage awards against directors and officers pursuant to these insurance agreements.

Certain of our non-employee directors may, through their relationships with their employers or partnerships, be insured and/or indemnified against certain liabilities in their capacity as members of our board of directors.

#### Warrant Plans
We have established a number of warrant plans, under which we have granted warrants to our employees, officers, directors, consultants and advisors.

Each of the warrants issued on September 8, 2021, December 28, 2022, July 31, 2024, January 30, 2025 and October 13, 2025 gives the holder thereof the right to subscribe to one of our ordinary shares. As of December 31, 2025, there were still 3,207,819 of such warrants granted and outstanding which entitle the holders thereof to an aggregate of 3,207,819 of our ordinary shares.

[**Table of Contents**](#TOC)

The duration of our outstanding warrants granted prior to August 2, 2024 is the shorter of ten years from the date of issuance or five years from the date of grant. The duration of our outstanding warrants granted as from August 2, 2024 is ten years from the date of issuance. With respect to warrants issued on September 8, 2021, December 28, 2022, July 31, 2024, January 30, 2025 and October 13, 2025 in principle one-fourth of such warrants granted to and accepted by a beneficiary vest upon the date of the grant, after which one fourth of the warrants granted to and accepted by a beneficiary vest on each of the first, second and third anniversary of the grant date. With respect to the warrants granted to directors on June 8, 2022 and on June 14, 2023, such warrants vest in full and become exercisable on the first anniversary of the grant date. With respect to the warrants granted to our Chief Executive Officer on August 2, 2024, such warrants vested in full and became exercisable on the grant date.

The table below sets forth the details of all warrants granted under the warrant plans in force as of December 31, 2025, including the plan under which the warrants were granted, the offer date, exercise price, expiry date, number of warrants exercised, number of warrants voided and number of warrants outstanding. Aside from the warrants set forth in the below table, there were no other stock options, options to purchase securities, or other rights to subscribe for or purchase outstanding securities as of December 31, 2025.

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| <br>**Name of Warrants Plan** | <br>**Number of**<br>**Warrants**<br>**Issued** | <br>**Number of**<br>**Warrants**<br>**lapsed,**<br>**exercised**<br>**or no**<br>**longer**<br>**available**<br>**for grant** | <br>**Number of**<br>**Warrants**<br>**Granted and** <br>**outstanding** | <br>**Issue**<br>**date** | <br>**Expiration**<br>**date** | <br>**Exercise**<br>**Price**<br>**Warrant**<br>**(€)** | <br>**Number**<br>**and type of**<br>**Shares**<br>**issuable**<br>**per ESOP**<br>**Warrant** | **Aggregate**<br>**number**<br>**and type of**<br>**Shares**<br>**issuable**<br>**upon**<br>**exercise of**<br>**outstanding**<br>**Warrants** |
| 2021 Warrants Plan | 1400000 | 570625 | 829375 | 09/08/2021 | 09/08/2031 | 25.31 (1) | 1 Ordinary Share | 829,375 Ordinary Shares |
|  |  |  |  |  |  | 17.76 (2) |  |  |
|  |  |  |  |  |  | 13.82 (3) |  |  |
|  |  |  |  |  |  | 12.95 (4) |  |  |
|  |  |  |  |  |  | 9.66(5) |  |  |
|  |  |  |  |  |  | 5.42(6) |  |  |
|  |  |  |  |  |  | 7.19(7) |  |  |
| 2022 Warrants Plan | 700000 | 134879 | 565121 | 12/28/2022 | 12/28/2032 | 7.19(8) | 1 Ordinary Share | 565,121 Ordinary Shares |
|  |  |  |  |  |  | 5.24(9) |  |  |
|  |  |  |  |  |  | 9.04(10) |  |  |
|  |  |  |  |  |  | 7.88(11) |  |  |
| 2024 Warrants Plan | 1000000 | 35250 | 962750 | 07/31/2024 | 07/31/2034 | 7.88(12) | 1 Ordinary Share | 964,750 Ordinary Shares |
|  |  |  |  |  |  | 7.20(13) |  |  |
|  |  |  |  |  |  | 8.04(14) |  |  |
|  |  |  |  |  |  | 7.69(15) |  |  |
|  |  |  |  |  |  | 9.63(16) |  |  |
|  |  |  |  |  |  | 10.15(17) |  |  |
|  |  |  |  |  |  | 4.92(18) |  |  |
| 2025 Warrants Plan | 805000 | 23750 | 780573 | 01/30/2025 | 01/30/2035 | 10.15(19) | 1 Ordinary Share | 781,250 Ordinary Shares |
|  |  |  |  |  |  | 10.80(20) |  |  |
|  |  |  |  |  |  | 7.20(21) |  |  |
|  |  |  |  |  |  | 5.65(22) |  |  |
|  |  |  |  |  |  | 4.92(23) |  |  |
|  |  |  |  |  |  | 5.56(24) |  |  |
| 2025-2 Warrants Plan | 760000 | 0 | 70000 | 10/13/2025 | 10/13/2025 | 5.56(25) | 1 Ordinary Share | 760,000 Ordinary Shares |
|  |  |  |  |  |  |  | **Total** | **3,900,496 Ordinary Shares** |

---

&nbsp;&nbsp;&nbsp;&nbsp;(1) For 16,685 2021 Warrants granted and accepted in 2021 and 2022.

&nbsp;&nbsp;&nbsp;&nbsp;(2) For 74,250 2021 Warrants granted and accepted in 2022.

&nbsp;&nbsp;&nbsp;&nbsp;(3) For 8,875 2021 Warrants granted and accepted in 2022.

&nbsp;&nbsp;&nbsp;&nbsp;(4) For 150,000 2021 Warrants granted and accepted in 2022.

&nbsp;&nbsp;&nbsp;&nbsp;(5) For 5,000 2021 Warrants granted and accepted in 2022.

&nbsp;&nbsp;&nbsp;&nbsp;(6) For 413,167 2021 Warrants granted and accepted in 2021, 2022 and 2023.

&nbsp;&nbsp;&nbsp;&nbsp;(7) For 161,398 2021 Warrants granted and accepted in 2023.

&nbsp;&nbsp;&nbsp;&nbsp;(8) For 13,602 2022 Warrants granted and accepted in 2023.

&nbsp;&nbsp;&nbsp;&nbsp;(9) For 207,625 2022 Warrants granted and accepted in 2024.

[**Table of Contents**](#TOC)

&nbsp;&nbsp;&nbsp;&nbsp;(10) For 85,000 2022 Warrants granted and accepted in 2024.

&nbsp;&nbsp;&nbsp;&nbsp;(11) For 258,894 2022 Warrants granted and accepted in 2024.

&nbsp;&nbsp;&nbsp;&nbsp;(12) For 221,606 2024 Warrants granted and accepted in 2024.

&nbsp;&nbsp;&nbsp;&nbsp;(13) For 100,000 2024 Warrants granted and accepted in 2024.

&nbsp;&nbsp;&nbsp;&nbsp;(14) For 26,963 2024 Warrants granted and accepted in 2024.

&nbsp;&nbsp;&nbsp;&nbsp;(15) For 300,000 2024 Warrants granted and accepted in 2024.

&nbsp;&nbsp;&nbsp;&nbsp;(16) For 150,000 2024 Warrants granted and accepted in 2025.

&nbsp;&nbsp;&nbsp;&nbsp;(17) For 149,181 2024 Warrants granted and accepted in 2025.

&nbsp;&nbsp;&nbsp;&nbsp;(18) **For 15,000 2024 Warrants granted and accepted in 2025.** 

&nbsp;&nbsp;&nbsp;&nbsp;(19) **For 223,943 2025 Warrants granted and accepted in 2025.** 

&nbsp;&nbsp;&nbsp;&nbsp;(20) **For 45,000 2025 Warrants granted and accepted in 2025.** 

&nbsp;&nbsp;&nbsp;&nbsp;(21) **For 10,000 2025 Warrants granted and accepted in 2025.** 

&nbsp;&nbsp;&nbsp;&nbsp;(22) **For 30,000 2025 Warrants granted and accepted in 2025.** 

&nbsp;&nbsp;&nbsp;&nbsp;(23) **For 461,630 2025 Warrants granted and accepted in 2025.** 

&nbsp;&nbsp;&nbsp;&nbsp;(24) **For 10,000 2025 Warrants granted and accepted in 2025.** 

&nbsp;&nbsp;&nbsp;&nbsp;(25) **For 70,000 2025-2 Warrants granted and accepted in 2025.** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;C. **Board Practices** 

#### Board Composition and Director Independence
As a foreign private issuer, under the listing requirements and rules of Nasdaq, we are not required to have a board of directors comprised of a majority of independent directors, except that our audit committee is required to consist fully of independent directors, subject to certain phase-in schedules. However, our board of directors has determined that, under current listing requirements and rules of Nasdaq and taking into account any applicable committee independence standards, Jürgen Hambrecht, Kevin Rakin, Rita Johnson-Mills, Virginia Kirby and Wildman Ventures LLC, as represented by Daniel Wildman, are "independent directors." In making such determination, our board of directors considered the relationships that each non-executive director has with us and all other facts and circumstances our board of directors deemed relevant in determining each director's independence, including the number of ordinary shares beneficially owned by the director and his or her affiliated entities (if any).

Under Belgian law, a director will only qualify as an independent director if he or she meets at least the criteria set out in provision 3.5 of the Belgian Code on Corporate Governance, which can be summarized as follows:

● Not be an executive, or exercising a function as a person entrusted with the daily management of the company or a related company or person, and not have been in such a position for the previous three years before their appointment. Alternatively, no longer enjoying stock options of the company related to this position.

● Not have served for a total term of more than twelve years as a non-executive board member.

● Not be an employee of the senior management (as defined in article 19,2° of the law of 20 September 1948 regarding the organization of the business industry) of the company or a related company or person, and not have been in such a position for the previous three years before their appointment. Alternatively, no longer enjoying stock options of the company related to this position.

● Not be receiving, or having received during their mandate or for a period of three years prior to their appointment, any significant remuneration or any other significant advantage of a patrimonial nature from the company or a related company or person, apart from any fee they receive or have received as a non-executive board member.

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● Not hold shares, either directly or indirectly, either alone or in concert, representing globally one tenth or more of the company's capital or one tenth or more of the voting rights in the company at the moment of appointment.

● Not having been nominated, in any circumstances, by a shareholder fulfilling the conditions covered under (e).

● Not maintain, nor have maintained in the past year before their appointment, a significant business relationship with the company or a related company or person, either directly or as partner, shareholder, board member, member of the senior management (as defined in article 19, 2° of the law of 20 September 1948 regarding the organization of the business industry) of a company or person who maintains such a relationship.

● Not be or have been within the last three years before their appointment, a partner or member of the audit team of the company or person who is, or has been within the last three years before their appointment, the external auditor of the company or a related company or person.

● Not be an executive of another company in which an executive of the company is a non- executive board member, and not have other significant links with executive board members of the company through involvement in other companies or bodies.

● Not have, in the company or a related company or person, a spouse, legal partner or close family member to the second degree, exercising a function as board member or executive or person entrusted with the daily management or employee of the senior management (as defined in article 19, 2° of the law of 20 September 1948 regarding the organization of the business industry), or falling in one of the other cases referred to in a) to i) above, and as far as point b) is concerned, up to three years after the date on which the relevant relative has terminated their last term.

#### Role of the Board in Risk Oversight
Our board of directors is responsible for the oversight of our risk management activities and has delegated to the audit committee the responsibility to assist our board in this task. While our board of directors oversees our risk management, our management is responsible for day-to-day risk management processes. Our board of directors expects our management to consider risk and risk management in each business decision, to proactively develop and monitor risk management strategies and processes for day-to-day activities and to effectively implement risk management strategies adopted by the board of directors. We believe this division of responsibilities is the most effective approach for addressing the risks we face.

#### Powers, Responsibilities and Functioning of the Board of Directors
We have a "one tier" governance structure whereby our board of directors is the ultimate decision making body, with the overall responsibility for the management and control of our company, and is authorized to carry out all actions that are considered necessary or useful to achieve our company's purpose. Our board of directors has all powers except for those reserved to the general shareholders' meeting by law or our articles of association. Our board of directors acts as a collegiate body.

Our board of directors has the power to appoint and remove the chief executive officer. The role of the chief executive officer is to implement the mission, strategy and targets set by the board of directors and to assume responsibility for the day-to-day management. The chief executive officer reports directly to the board of directors.

Pursuant to the Belgian CCA, and our articles of association, the board of directors must consist of at least three directors. Our corporate governance charter provides that the composition of the board of directors should ensure that decisions are made in the corporate interest. It should be determined on the basis of diversity, as well as complementary skills, experience and knowledge. Pursuant to the Belgian Code on Corporate Governance, a majority of the directors must be non-executive and at least three directors must be independent in accordance with the criteria set out in the Belgian Code on Corporate Governance. As of January 1, 2026, at least one third of the members of the Board of Directors had to be of the underrepresented gender, i.e. at least one third of the Board members had to be female. As of the date of this Annual Report, this requirement has not been met. As all current Board mandates will expire at the June 2026 general shareholders' meeting, the Board will submit proposals to that meeting for the (re)appointment of directors in such composition as necessary to ensure compliance with this requirement.

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Our directors are elected by our general shareholders' meeting. The term of the directors' mandates cannot exceed four years. Resigning directors can be re-elected for a new term. Proposals by the board of directors for the appointment or re-election of any director must be based on a recommendation by the nomination committee. In the event the office of a director becomes vacant, the remaining directors can appoint a successor temporarily filling the vacancy until the next general shareholders' meeting.

The general shareholders' meeting can dismiss the directors at any time.

The board of directors elects a chairperson from among its members on the basis of his or her knowledge, skills, experience and mediation strength. The chairperson is responsible for the leadership and the proper and efficient functioning of the board of directors. As of the date of this Annual Report, Robelga SRL (represented by Mr. Taub) is chairperson of the board of directors and Mr. Taelman is the chief executive officer. If the board of directors envisages appointing a former chief executive officer as chairperson, it will carefully consider the positive and negative aspects of such a decision and disclose why such appointment is in our best interest.

The board of directors meets as frequently as our interests require, or at the request of one or more directors. In principle, the board of directors will meet sufficiently regularly. The decisions of the board of directors are made by a simple majority of the votes cast. In case votes are tied, the chairperson of the board of directors will have a casting vote.

There are no arrangements or understanding between us and any of the members of our board of directors providing for benefits upon termination of their service.

#### Committees of our Board of Directors
Our board of directors is assisted by a number of committees in relation to specific matters. The committees advise the board of directors on these matters, but the decision making remains with the board of directors as a whole.

Our board of directors has established four board committees, which are responsible for assisting the board of directors and making recommendations in specific fields: (a) the audit committee (in accordance with article 7:99 of the Belgian CCA and provisions 4.10 and following of the Belgian Code on Corporate Governance), (b) the remuneration committee (in accordance with article 7:100 of the Belgian CCA and provisions 4.17 and following of the Belgian Code on Corporate Governance), (c) the nomination committee (in accordance with provisions 4.19 and following of the Belgian Code on Corporate Governance) and (d) the science & technology committee. The terms of reference of these board committees are primarily set out in the Corporate Governance Charter.

#### Audit Committee
As of the date of this Annual Report, our audit committee consists of three directors: Kevin Rakin (Chairman), Jürgen Hambrecht and Wildman Ventures, LLC, as represented by Daniel Wildman.

According to the Belgian CCA, all members of the audit committee must be non-executive directors, and at least one member must be independent within the meaning of provision 3.5 of the Belgian Code on Corporate Governance. Our board of directors has determined that all three members of our audit committee are independent under Rule 10A-3 of the Exchange Act and the applicable listing standards of Nasdaq and all three members of our audit committee are independent under the applicable rules of the Belgian Code on Corporate Governance.

The members of the audit committee must have a collective competence in our business activities, as well as in accounting, auditing and finance, and at least one member of the audit committee must have the necessary competence in accounting and auditing, including qualifying as an "audit committee financial expert" as defined under the Exchange Act. Our board of directors has determined that (i) Kevin Rakin, Jürgen Hambrecht and Wildman Ventures, LLC, as represented by Daniel Wildman, are independent under Rule 10A-3 of the Exchange Act and the applicable rules of NASDAQ, (ii) the members of the audit committee satisfy the competency requirement, and (iii) Kevin Rakin qualifies as an "audit committee financial expert" as defined under the Exchange Act.

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The audit committee is governed by a charter that complies with Nasdaq listing rules and the Belgian Code on Corporate Governance. The role of the audit committee is to:

● inform our board of directors of the result of the audit of the financial statements and the manner in which the audit has contributed to the integrity of the financial reporting and the role that the audit committee has played in that process;

● monitor the financial reporting process, and to make recommendations or proposals to ensure the integrity of the process,

● monitor the effectiveness of our internal control and risk management systems, and our internal audit process and its effectiveness;

● monitor the audit of the financial statements, including the follow-up questions and recommendations by the statutory auditor;

● assess and monitor the independence of the statutory auditor, in particular with respect to the appropriateness of the provision of additional services. More specifically, the audit committee analyses, together with the statutory auditor, the threats for the statutory auditor's independence and the security measures taken to limit these threats, when the total amount of fees exceeds the criteria specified in article 4 §3 of Regulation (EU) No 537/2014; and

● make recommendations to our board of directors on the selection, appointment and remuneration of our statutory auditor in accordance with article 16 §2 of Regulation (EU) No 537/2014.

The audit committee has at least four regularly scheduled meetings each year. The audit committee regularly reports to our board of directors on the exercise of its missions, and at least when the board of directors approves the financial statements and the condensed or short form financial information that will be published. The members of the audit committee have full access to the executive management and to any other employee to whom they may require access in order to carry out their responsibilities.

Without prejudice to the statutory provisions which determine that the statutory auditor must address reports or warnings to our corporate bodies, the statutory auditor must discuss, at the request of the statutory auditor, or at the request of the audit committee or of our board of directors, with the audit committee or with the board of directors, essential issues which are brought to light in the exercise of the statutory audit of the financial statements, which are included in the additional statement to the audit committee, as well as any meaningful shortcomings discovered in our internal financial control system.

#### Remuneration Committee
As of the date of this Annual Report, our remuneration committee consists of three directors: Wildman Ventures, LLC, as represented by Daniel Wildman (Chairman), Rita Johnson-Mills and Jürgen Hambrecht.

In line with the Belgian CCA and the Belgian Code on Corporate Governance (i) all members of the remuneration committee are non-executive directors, (ii) the remuneration committee consists of a majority of independent directors and (iii) the remuneration committee is chaired by the chairperson of our board of directors or another non-executive director appointed by the committee. Our board of directors has determined that two members of our remuneration committee are independent under the applicable listing standards of Nasdaq and two members of our remuneration committee are independent under the applicable rules of the Belgian Code on Corporate Governance.

Pursuant to the Belgian CCA, the remuneration committee must have the necessary expertise in terms of remuneration policy. Our board of directors has determined that the members of the remuneration committee satisfy this requirement.

The role of the remuneration committee is to make recommendations to the board of directors with regard to the remuneration of directors and members of the executive management and, in particular, to:

● make proposals to the board of directors on the remuneration policy of directors, the persons in charge of the management, and the persons in charge of the daily management, as well as, where applicable, the resulting proposals that the board of directors must submit to the general shareholders' meeting;

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● make proposals to the board of directors on the individual remuneration of the directors, the other persons in charge of the management, and the persons in charge of day-to-day management, including variable remuneration and long-term performance premiums, whether or not tied to shares, in the form of stock options or other financial instruments, and of severance payments, and where applicable, the resulting proposals that the board of directors must submit to the general shareholders' meeting;

● prepare the remuneration report; and

● explain the remuneration report at the annual general shareholders' meeting.

Pursuant to the Belgian CCA, the chief executive officer participates in the meetings of the remuneration committee in an advisory capacity each time the remuneration of another member of the executive management is being discussed.

#### Nomination Committee
As of the date of this Annual Report, our nomination committee consists of three directors: Rita Johnson-Mills (Chairwoman), Robelga SRL, as represented by Robert Taub, and Jürgen Hambrecht.

In line with the Belgian Code on Corporate Governance (i) the nomination committee consists of a majority of independent directors and (iii) the nomination committee is chaired by the chairperson of our board of directors or another non-executive director appointed by the committee. Our board of directors has determined that two members of our nomination committee are independent under the applicable standards of Nasdaq and two members of our nomination committee are independent under the applicable rules of the Belgian Code on Corporate Governance.

The role of the nomination committee is to:

● make recommendations to our board of directors with regard to the appointment of directors and members of the executive management;

● make recommendations to our board of directors in relation to the assignment of responsibilities to the executives;

● prepare plans for the orderly succession of board members;

● lead the reappointment process of board members;

● ensure that sufficient and regular attention is paid to the succession of executives; and

● ensure that appropriate talent development programs and programs to promote diversity in leadership are in place.

#### Science & Technology Committee
As of the date of this Annual Report, our science & technology committee consists of four directors: Pierre Gianello (Chairman), Robelga SRL, as represented by Robert Taub, and Virginia Kirby.

The role of science & technology committee is to assist our board of directors in all matters relating to:

● strategic direction of our technology, research and product development programs;

● monitoring and evaluating existing and future trends in technology that may affect our strategic plans, including monitoring of overall industry trends;

● the innovation and technology acquisition process to assure ongoing business growth;

● IT risk management and cyber security strategy; and

● measurement and tracking systems in place to monitor the performance of our technology in support of overall business strategy and to achieve successful innovation.

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#### Corporate Governance Code
We adopted a corporate governance charter that is in line with the Belgian Code on Corporate Governance. The corporate governance charter describes the main aspects of the corporate governance of our company, including our governance structure, the terms of reference of our board of directors and its committees and other important topics. The corporate governance charter must be read together with our articles of association.

The Belgian Code on Corporate Governance is based on a "comply or explain" system: Belgian listed companies are expected to follow the Belgian Code on Corporate Governance, but can deviate from specific provisions and guidelines (though not the principles) provided they disclose the justification for such deviations. We apply the ten corporate governance principles contained in the Belgian Code on Corporate Governance and comply with the corporate governance provisions set forth in the Belgian Code on Corporate Governance, except in relation to the following:

● In deviation of provision 4.14 of the Belgian Code on Corporate Governance, no independent internal audit function has been established. This deviation is explained by our size. Our audit committee will regularly assess the need for the creation of an independent internal audit function and, where appropriate, will call upon external persons to conduct specific internal audit assignments and will inform the board of directors of their outcome.

● We do not exclude awarding share-based incentives to the non-executive directors. This is contrary to provision 7.6 of the Belgian Code on Corporate Governance that provides that no stock options should be granted to non-executive board members. We believe that this provision of the Belgian Code on Corporate Governance is not appropriate and adapted to take into account the realities of companies in the biotech and life sciences industry that are still in a development phase. Notably, the ability to remunerate non-executive directors with share options allows us to limit the portion of remuneration in cash that we would otherwise need to pay to attract or retain renowned experts with the most relevant skills, knowledge and expertise. We are of the opinion that granting non-executive directors the opportunity to be remunerated in part in share-based incentives rather than all in cash strengthens the alignment of their interests with the interests of our shareholders. This is in our interest and the interest of our stakeholders. Furthermore, this is customary for directors active in companies in the life sciences industry.

● In deviation of provision 7.6 of the Belgian Code on Corporate Governance, the non-executive members of our board of directors do not systematically receive part of their remuneration in the form of shares. This deviation is explained by the fact that the interests of the non-executive members of our board of directors are considered to be sufficiently oriented to the creation of long-term value for our company, taking into account that some of the non-executive members of our board of directors will from time to time hold shares or warrants under our outstanding stock-based incentive plans, the value of which is based on the value of the shares. Therefore, a regular payment in shares is not deemed necessary. That being said, in our June 2024 the shareholders' meeting, our shareholders approved the annual grant to non-executive directors of so-called "restricted share units", or RSUs as further described in our remuneration policy and in "—Compensation—Directors' and Executive Officers' Compensation—Directors' Compensation" above. While the RSUs are not entirely equivalent to shares (no voting rights, no preferential subscription rights or other membership rights), in the opinion of the Company, the RSUs meet the objectives provided for in provision 7.6 of the 2020 Code.

● Pursuant to article 7:91 of the Belgian CCA and provisions 7.6 and 7.11 of the Belgian Code on Corporate Governance, shares should not vest and share options should not be exercisable within three years as of their granting. Our board of directors has been explicitly authorized in our articles of association to deviate from this rule in connection with stock-based incentive plans, compensations, awards and issuances to our employees, directors and service providers and/or our subsidiaries (from time to time). We are of the opinion that this allows for more flexibility when structuring share-based awards.

● In deviation of provision 7.9 of the Belgian Code on Corporate Governance, no minimum threshold of shares to be held by members of our executive management team is set. This deviation is explained by the fact that the interests of the members of the executive management team are considered to be sufficiently oriented to the creation of long-term value for our company, taking into account that some of them will from time to time hold shares or warrants under our outstanding stock-based incentive plans, the value of which is based on the value of the shares. Therefore, setting a minimum threshold of shares to be held by them is not deemed necessary.

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● In deviation of provision 7.12 of the 2020 Code, the board of directors does not include, in the contracts with the CEO and other members of executive management, provisions that would enable the Company to recover variable remuneration paid, or withhold the payment of variable remuneration, and specify the circumstances in which it would be appropriate to do so, insofar as enforceable by law. The Company believes that this provision of the 2020 Code is not appropriate and adapted to take into account the realities of companies in the life sciences industry that are still in a development phase nor considers that it is necessary, except as provided in the Company's Clawback Policy pursuant to applicable U.S. securities laws, to apply claw-back provisions as (i) the pay-out of the short-term variable remuneration, based on the achievement of one or more individual objectives and one or more Company objectives as set by the board of directors, is paid only upon achievement of those objectives, and (ii) the Company does not apply any other performance-based remuneration or variable compensation. Furthermore, the ESOP warrant plans set up by the Company contain bad leaver provisions that can result in the unexercised share options, whether vested or not, automatically and immediately becoming null and void if the agreement or other relationship between the holder and the (relevant subsidiary of the) Company is terminated for "cause". Notwithstanding the Company's position that warrants are not to be qualified as variable remuneration (when not depending on performance criteria), the board of directors is of the opinion that such bad leaver provisions sufficiently protect the Company's interests and that it is therefore currently not necessary to provide for additional contractual provisions that give the Company a contractual right to reclaim any (variable) remuneration from the members of the executive management. For those reasons, there are no contractual provisions in place between the Company and the members of the executive management that give the Company a contractual right to reclaim from said executives any variable remuneration that would be awarded.

What constitutes good corporate governance will evolve with the changing circumstances of a company and with the standards of corporate governance globally, and must be tailored to meet those changing circumstances. Our board of directors intends to update the corporate governance charter as often as required to reflect changes to our corporate governance.

Our articles of association and the corporate governance charter are available on our website (www.nyxoah.com) and can be obtained free of charge at our registered office. Information contained on our website does not constitute part of this Annual Report.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;D. **Employees** 

The number of employees by function and geographic location as of the end of the period for our fiscal years ended December 31, 2025, 2024 and 2023 was as follows:

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| | | | |
|:---|:---|:---|:---|
|  | **As at December 31,**  | **As at December 31,**  | **As at December 31,**  |
|  | **2025** | **2024** | **2023** |
| **By Function:** |  |  |  |
| Sales, General & Administration | 81.2 | 56.5 | 40.4 |
| Research & Development | 72.5 | 127.1 | 106.4 |
| Total | **153.7** | **183.6** | **146.8** |
| **By Geography:** |  |  |  |
| Europe (Belgium & Germany & UK) | 67.1 | 82.4 | 61.4 |
| Israel | 6.6 | 45.2 | 46.4 |
| Australia | 2 | 3 | 4 |
| United States | 78 | 53 | 35 |
| Total | **153.7** | **183.6** | **146.8** |

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None of our employees are represented by labor unions or covered by company specific bargaining agreements.

We believe that one of our key strengths is our employee base, which has extensive know-how across research, manufacturing, quality-control, engineering software programming and marketing and sales. We also believe that developing a diverse, equitable and inclusive culture is critical to continuing to attract and retain the top talent necessary for our long-term success and strategy. We value diversity at all levels and continue to focus on extending our diversity and inclusion initiatives across our entire workforce, including the expansion of individuals with diverse backgrounds in leadership.

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Our principles of accountability, honesty, integrity and customer-focused, serve as our cultural pillars. We focus our efforts on creating a collaborative environment where our colleagues feel respected and valued. We provide our employees with competitive compensation, opportunities for equity ownership and a robust employment package, including health care, disability and long-term planning insurance, retirement planning and paid time off. In addition, we regularly interact with our employees to gauge employee satisfaction and identify areas of focus.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;E. **Share Ownership** 

For information regarding the share ownership of our directors and executive officers, see "Item 6.B—Compensation" and "Item 7.A—Major Shareholders."

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**F.** **Disclosure of a Registrant's Action to Recover Erroneously Awarded Compensation** 

Not applicable.

#### Item 7. Major Shareholders and Related Party Transactions
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A. **Major Shareholders** 

The following table and related footnotes set forth information with respect to the beneficial ownership of our ordinary shares as of March 1, 2026 by:

● each of our directors and executive officers; and

● each person beneficially owning more than 3% of our share capital; and

● all of our directors and executive officers as a group.

To our knowledge and assuming that all of our ordinary shares listed on the Nasdaq Global Market are held by residents of the United States, as of March 1, 2026, we estimate that approximately 19.2% of our outstanding ordinary shares are held of record by nine residents of the United States. The actual number of holders is greater than these numbers of record holders and includes beneficial owners whose ordinary shares are held in street name by brokers and other nominees. This number of holders of record also does not include holders whose shares may be held in trust by other entities.

Beneficial ownership is determined according to the rules of the SEC and generally means that a person has beneficial ownership of a security if he, she or it possesses sole or shared voting or investment power of that security, including ordinary shares that can be acquired within 60 days of March 1, 2026. Ordinary shares subject to derivative securities currently exercisable or exercisable within 60 days of March 1, 2026 are deemed to be outstanding for computing the percentage ownership of the person holding these securities and the percentage ownership of any group of which the holder is a member, but are not deemed outstanding for computing the percentage of any other person.

The percentage ownership information shown in the table is based on 43,662,403 ordinary shares outstanding as of March 1, 2026.

Except as indicated by the footnotes below, we believe, based on the information furnished to us, that the persons named in the table below have sole voting and investment power with respect to all ordinary shares shown that they beneficially own, subject to community property laws where applicable. The information does not necessarily indicate beneficial ownership for any other purpose, including for purposes of Sections 13(d) and 13(g) of the Securities Act.

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Except as otherwise indicated in the table below, addresses of the directors, members of the executive management team and named beneficial owners are in care of Nyxoah SA, Rue Edouard Belin 12, 1435 Mont-Saint-Guibert, Belgium.

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| | | |
|:---|:---|:---|
| | **Ordinary Shares** | **Ordinary Shares** |
| | **Beneficially** | **Beneficially** |
| | **Owned** | **Owned** |
| <br>**Name of beneficial owner** | **Number** | **Percent** |
| ***3% or Greater Shareholders:*** |  |  |
| Cochlear Investments Pty Ltd(1) | 5847283 | 13.4% |
| Robert Taub(2) | 4360800 | 9.9% |
| Entities affiliated with Gilde Healthcare(3) | 2936890 | 6.7% |
| TOGETHER Partnership(4) | 2940258 | 6.7% |
| Resmed Inc.(5) | 1727864 | 4.0% |
| Jürgen Hambrecht(6) | 1458806 | 3.3% |
| BNP Paribas SA(7) | 1409791 | 3.2% |
| ***Executive Officers and Directors:*** |  |  |
| Robert Taub(2) | 4360800 | 9.9% |
| Kevin Rakin(8) | 188306 | \*% |
| Virginia Kirby(9) | 70366 | \*% |
| Pierre Gianello(10) | 71560 | \*% |
| Wildman Ventures LLC (as represented by Daniel Wildman)(11) | 52306 | \*% |
| Jürgen Hambrecht(6) | 1458806 | 3.3% |
| Rita Johnson-Mills(12) | 70366 | \*% |
| Olivier Taelman(13) | 613335 | 1.4% |
| John Landry(14) | 162500 | \*% |
| Bruno Onkelinx(15) | 83292 | \*% |
| Scott Holstine(16) | 58250 | \*% |
| All current directors and executive management as a group (11 persons)(17) | 7189887 | 16.4% |

---

\* Represents beneficial ownership of less than one percent.

&nbsp;&nbsp;&nbsp;&nbsp;(1) Consists of 5,847,283 ordinary shares held by Cochlear Investments Pty Ltd. The principal business address of Cochlear Investments Pty Ltd. is 1 University Avenue, Macquarie University, NSW 2109 (Australia). 100% of the share capital of Cochlear Investments Pty Ltd is owned by Cochlear Limited, a company which is listed on the Australian Securities Exchange and is not a controlled company.

&nbsp;&nbsp;&nbsp;&nbsp;(2) Consists of (i) 2,712,510 ordinary shares held by Robert Taub, representative of Robelga SRL, a member of our board of directors, (ii) 1,598,290 ordinary shares held by Robelga SRL, a member of our board of directors, and controlled by Mr. Taub, and (iii) 50,000 ordinary shares issuable upon the exercise of warrants held by Mr. Taub that are immediately exercisable or exercisable within 60 days of March 1, 2026.

&nbsp;&nbsp;&nbsp;&nbsp;(3) Consists of (i) 1,468,445 ordinary shares held by Coöperatieve Gilde Healthcare III Sub-Holding U.A., or Gilde Sub-Holding, and (ii) 1,468,445 ordinary shares held by Coöperatieve Gilde Healthcare III Sub-Holding 2 U.A., or Gilde Sub-Holding 2. The principal business address of each of Gilde Sub-Holding and Gilde Sub-Holding 2 is Newtonlaan 91, 3584 BP Utrecht, The Netherlands. Gilde Healthcare III Management BV is the management company of Gilde Sub-Holding and Gilde Sub-Holding 2. Gilde Healthcare III Management BV exercises the voting rights attached to our ordinary shares at its discretion. Gilde Healthcare III Management BV is controlled by Gilde Healthcare Holding BV. Gilde Healthcare Holding BV is not a controlled entity.

&nbsp;&nbsp;&nbsp;&nbsp;(4) Consists of 2,940,258 ordinary shares held by TOGETHER Partnership. The principal business address of TOGETHER Partnership is Van Putlei 31, 2018 Antwerp, Belgium. TOGETHER Partnership is not a controlled entity.

&nbsp;&nbsp;&nbsp;&nbsp;(5) Consists of 1,727,864 ordinary shares held by Resmed Inc. The principal business address of Resmed Inc. is 9001 Spectrum Center Boulevard., San Diego, CA 92123. Resmed Inc. is a public company that is listed on the New York Stock Exchange and is not a controlled company.

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&nbsp;&nbsp;&nbsp;&nbsp;(6) Consists of (i) 137,395 ordinary shares held by Dr. Hambrecht, a member of our board of directors, (ii) 1,271,411 ordinary shares held by JH Capital GmbH, a company controlled by Dr. Hambrecht, and (iii) 50,000 ordinary shares issuable upon the exercise of warrants held by Dr. Hambrecht that are immediately exercisable or exercisable within 60 days of March 1, 2025.

&nbsp;&nbsp;&nbsp;&nbsp;(7) Consists of 1,409,791 ordinary shares held by BNP Paribas Asset Management Europe SAS, which is controlled by BNP Paribas Asset Management Holding, which is controlled by BNP Paribas SA. BNP Paribas Asset Management Europe SAS is an investment company that exercises voting rights on a discretionary basis in the absence of specific instructions. The principal business address of BNP Paribas Asset Management SA (which is the person subject to the Belgian transparency notification requirement) is SA 47000-75318 Paris cedex 09-France.

&nbsp;&nbsp;&nbsp;&nbsp;(8) Consists of (i) 92,836 ordinary shares held by Mr. Rakin, (ii) 45,470 ordinary shares held by Kevin L. Rakin Irrevocable Trust, and (iii) 50,000 ordinary shares issuable upon the exercise of warrants held by Mr. Rakin that are immediately exercisable or exercisable within 60 days of March 1, 2026.

&nbsp;&nbsp;&nbsp;&nbsp;(9) Consists of (i) 20,366 ordinary shares held by Ms. Kirby, and (ii) 50,000 ordinary shares issuable upon the exercise of warrants held by Ms. Kirby that are immediately exercisable or exercisable within 60 days of March 1, 2026.

&nbsp;&nbsp;&nbsp;&nbsp;(10) Consists of (i) 21,560 ordinary shares held by Mr. Gianello, and (ii) 50,000 ordinary shares issuable upon the exercise of warrants held by Mr. Gianello that are immediately exercisable or exercisable within 60 days of March 1, 2026.

&nbsp;&nbsp;&nbsp;&nbsp;(11) Consists of (i) 12,500 ordinary shares held by Mr. Wildman, representative of Wildman Ventures, LLC, (ii) 14,806 ordinary shares held by Wildman Ventures, LLC, as represented by Mr. Wildman, and (iii) 25,000 ordinary shares issuable upon the exercise of warrants held by Wildman Ventures LLC, as represented by Mr. Wildman, that are immediately exercisable or exercisable within 60 days of March 1, 2026

&nbsp;&nbsp;&nbsp;&nbsp;(12) Consists of (i) 20,366 ordinary shares held by Ms. Johnson-Mills, and (ii) 50,000 ordinary shares issuable upon the exercise of warrants held by Mr. Johnson-Mills that are immediately exercisable or exercisable within 60 days of March 1, 2026.

&nbsp;&nbsp;&nbsp;&nbsp;(13) Consists of (i) 12,500 ordinary shares held by Mr. Taelman and (ii) 600,835 ordinary shares issuable upon the exercise of warrants held by Mr. Taelman that are immediately exercisable or exercisable within 60 days of March 1, 2026.

&nbsp;&nbsp;&nbsp;&nbsp;(14) Consists of (i) 12,500 ordinary shares held by Mr. Landry and (ii) 150,000 ordinary shares issuable upon the exercise of warrants held by Mr. Landry that are immediately exercisable or exercisable within 60 days of March 1, 2026.

&nbsp;&nbsp;&nbsp;&nbsp;(15) Consists of (i) 1,464 ordinary shares held by Mr. Onkelinx, and (ii) 81,828 ordinary shares issuable upon the exercise of warrants held by Mr. Onkelinx that are immediately exercisable or exercisable within 60 days of March 1, 2026.

&nbsp;&nbsp;&nbsp;&nbsp;(16) Consists of (i) 33,250 ordinary shares held by Mr. Holstine and (ii) 25,000 ordinary shares issuable upon the exercise of warrants held by Mr. Holstine that are immediately exercisable or exercisable within 60 days of March 1, 2026.

&nbsp;&nbsp;&nbsp;&nbsp;(17) Consists of (i) 6,007,224 ordinary shares and (ii) 1,182,663 ordinary shares issuable upon the exercise of warrants that are immediately exercisable or exercisable within 60 days of March 1, 2026.

To our knowledge, other than as provided in the table above, our other filings with the SEC and this Annual Report, there has been no significant change in the percentage ownership held by any major shareholder above in the last three years.

The major shareholders listed above do not have voting rights with respect to their ordinary shares that are different from the voting rights of other holders of our ordinary shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;B. **Related Party Transactions** 

The following is a description of related party transactions we have entered into since January 1, 2023 with any members of our board of directors or executive officers or the holders of more than 3% of our share capital.

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#### Agreements with Olivier Taelman
From September 1, 2021 until August 19, 2024, Olivier Taelman performed his function as CEO of the Company on a self-employed basis in accordance with a service agreement between Nyxoah SA and Olivier Taelman. As from August 19, 2024, Olivier Taelman temporarily relocated to the U.S. Since then and until he moved back to Belgium as from September 1, 2025, he performed his function as CEO of the Company partially on a self-employed basis in accordance with a service agreement, dated as of August 19, 2024, between Nyxoah SA and Olivier Taelman and partially as employee of Nyxoah Inc. Since September 1, 2025, Olivier Taelman performs his function as CEO of the Company on a self-employed basis in accordance with said service agreement between Nyxoah SA and Olivier Taelman.

Pursuant to the terms of these agreements, Mr. Taelman was entitled to receive an annual fee equal to $360,000 plus the euro equivalent of $90,000 (from August 19, 2024 until September 30, 2025) and will be entitled to receive an annual fee of €500,000 (since October 1, 2025), as well as a short term incentive and a long term incentive (in the form of the grant of warrants) in accordance with our remuneration policy as approved from time to time by the shareholders at the shareholders meeting of the Company. Mr. Taelman will continue to benefit from a company car, a laptop, a mobile phone, an occupational pension scheme and a hospitalization insurance. The service agreement has an indefinite term and can be terminated by either us or Mr. Taelman at any time subject to a notice of three months, supplemented with one month per completed year of services under the service agreement, with a maximum total notice period of nine months. We can immediately terminate the service agreement in case of serious cause. The employment with Nyxoah Inc terminated as of September 1, 2025.

**November 2025 Private Placement**

On November 13, 2025, we announced that Robert Taub, who represents Robelga SRL as chairman of our board of directors, Daniel Wildman, who represents Wildman Ventures LLC as member of our board of directors Olivier Taelman, John Landry and Scott Holstine had expressed interest in participating in the Private Placement. Our board of directors approved their participation on November 13, 2025, pursuant to the related parties procedure of Article 7:97 of the Belgian Companies and Associations Code. In connection with the Private Placement, we issued ordinary shares at a subscription price per share of €4.00, for aggregate gross proceeds of approximately €17.0 million.

**May 2024 Offering**

On May 23, 2024, we announced that Robert Taub, who represents Robelga SRL as chairman of our board of directors, had expressed interest in participating in an underwritten public offering, or the May 2024 Offering, of our ordinary shares prior to the launch of the offering, it being understood that the number of shares allocated to Mr. Taub, if any, and the applicable price would depend on the outcome of the offering process. Our board of directors approved Mr. Taub's participation on May 22, 2024, pursuant to the related parties procedure of Article 7:97 of the Belgian Companies and Associations Code. In connection with the May 2024 Offering, we issued an aggregate of 5,674,755 ordinary shares, inclusive of a partial exercise of the underwriters' overallotment option, for aggregate gross proceeds of €48.5 million, or €8.54 per share.

#### Warrants to Our Board Directors and Executive Management
We have granted warrants to certain members of our board of directors and executive management. For more information regarding the warrants granted to our board of directors and executive Management, see "—Directors' and Executive Officers' Compensation."

#### Policies and Procedures for Related Person Transactions
We have adopted a related person transaction policy requiring that all related person transactions required to be disclosed by a foreign private issuer pursuant to the Exchange Act be approved by the audit committee or another independent body of our board of directors.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;C. **Interests of Experts and Counsel** 

Not Applicable.

#### Item 8. Financial Information
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A. **Consolidated Statements and Other Financial Information** 

See "Item 18. Financial Statements."

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#### Legal Proceedings
For more information see "Information on the Group—B. Business Overview—Legal Proceedings".

#### Dividend Policy
We have never declared or paid any cash dividends on our ordinary shares. We do not anticipate paying cash dividends on our equity securities in the foreseeable future and intend to retain all available funds and any future earnings for use in the operation and expansion of our business. In general, distributions of dividends proposed by our board of directors require the approval of our shareholders at a meeting of shareholders with a simple majority vote, although our board of directors may declare interim dividends without shareholder approval, subject to the terms and conditions of the Belgian Code of Companies and Associations, or CCA.

Our ability to distribute dividends is subject to availability of sufficient distributable profits as defined under Belgian law on the basis of our stand-alone statutory accounts prepared in accordance with Belgian GAAP. In particular, dividends can only be distributed if following the declaration and issuance of the dividends the amount of our net assets on the date of the closing of the last financial year as follows from the statutory non-consolidated financial statements (i.e., summarized, the amount of the assets as shown in the balance sheet, decreased with provisions and liabilities, all in accordance with Belgian accounting rules), and, save in exceptional cases, to be mentioned and justified in the notes to the annual accounts, decreased with the non-amortized costs of incorporation and extension and the non-amortized costs for research and development, does not fall below the amount of the paid-up capital (or, if higher, the issued capital), increased with the amount of non-distributable reserves (which include, as the case may be, the unamortized part of any revaluation surpluses).

In addition, pursuant to Belgian law and our Articles of Association, we must allocate an amount of 5% of our Belgian GAAP annual net profit to a legal reserve in its stand-alone statutory accounts, until the legal reserve amounts to 10% of our share capital. Our legal reserve currently does not meet this requirement nor will it meet the requirement at the time of the closing. Accordingly, 5% of our Belgian GAAP annual net profit during future years will need to be allocated to the legal reserve, further limiting our ability to pay out dividends to its shareholders.

For information regarding the Belgian withholding tax applicable to dividends and related U.S. reimbursement procedures, see "Material United States Federal Income and Belgian Tax Considerations — Material Belgian Tax Consequences."

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;B. **Significant Changes** 

Other than the information set forth herein, there have been no significant changes since December 31, 2024.

#### Item 9. The Offer and Listing
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A. **Offer and Listing Details** 

Our ordinary shares are listed on The Nasdaq Global Market under the symbol "NYXH" and the on Euronext Brussels under the symbol "NYXH."

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;B. **Plan of Distribution** 

Not Applicable.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;C. **Markets** 

Our ordinary shares are listed on The Nasdaq Global Market under the symbol "NYXH" and the on Euronext Brussels under the symbol "NYXH."

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;D. **Selling Shareholders** 

Not Applicable.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;E. **Dilution** 

Not Applicable.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;F. **Expenses of the Issue** 

Not Applicable.

#### Item 10. Additional Information
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A. **Share Capital** 

Not Applicable.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;B. **Articles of Association** 

The information set forth in Exhibit 2.2 to this annual report is incorporated herein by reference.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;C. **Material Contracts** 

Except as otherwise disclosed in this Annual Report (including the exhibits thereto), we are not currently, and have not been in the last two years, party to any material contract, other than contracts entered into in the ordinary course of our business.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;D. **Exchange Controls** 

There are no Belgian exchange control regulations that impose limitations on our ability to make, or the amount of, cash payments to residents of the United States.

We are in principle under an obligation to report to the National Bank of Belgium certain cross-border payments, transfers of funds, investments and other transactions in accordance with applicable balance-of- payments statistical reporting obligations. Where a cross-border transaction is carried out by a Belgian credit institution on our behalf, the credit institution will in certain circumstances be responsible for the reporting obligations.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;E. **Taxation** 

#### Material U.S. Federal Income Tax Considerations

#### Certain Material U.S. Federal Income Tax Considerations to U.S. Holders
The following is a summary of certain material U.S. federal income tax considerations relating to the ownership and disposition of ordinary shares by a U.S. holder (as defined below) that is based on the U.S. Internal Revenue Code of 1986, as amended, or the Code; existing, proposed and temporary U.S. Treasury Regulations promulgated thereunder, administrative and judicial interpretations thereof; and the U.S.-Belgium Tax Treaty (as defined below), in each case as of and available on the date hereof. All the foregoing is subject to change, which change could apply retroactively, and to differing interpretations, all of which could affect the tax considerations described below. There can be no assurances that the U.S. Internal Revenue Service, or the IRS, will not take a contrary or different position concerning the tax consequences of the ownership and disposition of the ordinary shares or that such a position would not be sustained. Holders should consult their own tax advisers concerning the U.S. federal, state, local and non-U.S. tax consequences of owning, and disposing of the ordinary shares in their particular circumstances.

This summary addresses only the U.S. federal income tax considerations for U.S. holders of our ordinary shares that will hold such ordinary shares as capital assets for U.S. federal income tax purposes. This summary does not address all U.S. federal income tax matters that may be relevant to a particular U.S. holder and does not address all tax considerations that may be applicable to a holder of ordinary shares that may be subject to special tax rules including, without limitation, the following:

● banks, financial institutions or insurance companies;

● brokers, dealers or traders in securities, currencies, commodities, or notional principal contracts;

● tax-exempt entities or organizations, including an "individual retirement account" or "Roth IRA" as defined in Section 408 or 408A of the Code, respectively;

● real estate investment trusts, regulated investment companies or grantor trusts;

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● persons that hold the ordinary shares as part of a "hedging," "integrated" or "conversion" transaction or as a position in a "straddle" for U.S. federal income tax purposes;

● partnerships (including entities classified as partnerships for U.S. federal income tax purposes) or other pass-through entities (including S Corporations), or persons that will hold the ordinary shares through such an entity;

● persons that received our ordinary shares as compensation for the performance of services;

● certain former citizens or long-term residents of the United States;

● persons that hold our ordinary shares through a permanent establishment or fixed base outside the United States;

● U.S. holders that own directly, indirectly, or through attribution 10% or more of the voting power or value of our ordinary shares; and

● U.S. holders that have a "functional currency" for U.S. federal income tax purposes other than the U.S. dollar.

Further, this summary does not address the U.S. federal estate, gift, or alternative minimum tax considerations, or any U.S. state, local, or non-U.S. tax considerations of the ownership and disposition of the ordinary shares.

If a partnership (or any other entity or arrangement treated as a partnership for U.S. federal income tax purposes) holds ordinary shares, the U.S. federal income tax consequences relating to an investment in our ordinary shares will depend in part upon the status of the partner and the activities of the partnership. Such a partner or partnership should consult its tax advisor regarding the U.S. federal income tax considerations of owning and disposing of our ordinary shares in its particular circumstances.

For the purposes of this summary, a "U.S. holder" is a beneficial owner of ordinary shares that is (or is treated as), for U.S. federal income tax purposes:

● an individual who is a citizen or resident of the United States;

● a corporation, or other entity that is treated as a corporation for U.S. federal income tax purposes, created or organized in or under the laws of the United States, any state thereof, or the District of Columbia;

● an estate, the income of which is subject to U.S. federal income taxation regardless of its source; or

● a trust, if a court within the United States is able to exercise primary supervision over its administration and one or more United States persons (within the meaning of Section 7701(a)(30) of the Code) have the authority to control all of the substantial decisions of such trust or has a valid election in effect under applicable U.S. Treasury Regulations to be treated as a United States person.

As indicated below, this discussion is subject to U.S. federal income tax rules applicable to a "passive foreign investment company", or PFIC.

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**This discussion is for informational purposes only and is not tax advice. Persons considering an investment in our ordinary shares should consult their own tax advisors as to the particular tax consequences applicable to them relating to ownership and disposition of our ordinary shares, including the applicability of U.S. federal, state and local tax laws and non-U.S. tax laws.**

***Distributions***. Although we do not currently plan to pay dividends, and subject to the discussion under "- Passive Foreign Investment Company Considerations" below, the gross amount of any distribution (before reduction for any amounts withheld in respect of Belgian withholding tax) actually or constructively received by a U.S. holder with respect to ordinary shares will be taxable to the U.S. holder as a dividend to the extent of the U.S. holder's pro rata share of our current and accumulated earnings and profits as determined under U.S. federal income tax principles. Distributions in excess of earnings and profits will be non-taxable to the U.S. holder to the extent of, and will be applied against and reduce, the U.S. holder's adjusted tax basis in the ordinary shares. Distributions in excess of earnings and profits and such adjusted tax basis will generally be taxable to the U.S. holder as either long-term or short-term capital gain depending upon whether the U.S. holder has held the ordinary shares for more than one year as of the time such distribution is received. However, since we do not calculate our earnings and profits under U.S. federal income tax principles, it is expected that any distribution will be reported as a dividend, even if that distribution would otherwise be treated as a non-taxable return of capital or as capital gain under the rules described above. Non-corporate U.S. holders may qualify for the preferential rates of taxation with respect to dividends on ordinary shares applicable to long-term capital gains (i.e., gains from the sale of capital assets held for more than one year) and applicable to qualified dividend income (as discussed below) if we are a "qualified foreign corporation" and certain other requirements (discussed below) are satisfied. A non-U.S. corporation (other than a corporation that is classified as a PFIC for the taxable year in which the dividend is paid or the preceding taxable year) generally will be considered to be a qualified foreign corporation (a) if it is eligible for the benefits of a comprehensive tax treaty with the United States which the Secretary of Treasury of the United States determines is satisfactory for purposes of this provision and which includes an exchange of information provision, or (b) with respect to any dividend it pays on ordinary shares which are readily tradable on an established securities market in the United States. The ordinary shares are listed on the Nasdaq Global Select Market, or Nasdaq, which is an established securities market in the United States, and we expect the ordinary shares to be readily tradable on Nasdaq. However, there can be no assurance that the ordinary shares will be considered readily tradable on an established securities market in the United States in the current year or any future years. We are incorporated under the laws of Belgium, and we believe that we qualify as a resident of Belgium for purposes of, and are eligible for the benefits of, The Convention between the Government of the United States of America and the Government of the Kingdom of Belgium for the Avoidance of Double Taxation and the Prevention of Fiscal Evasion with Respect to Taxes on Income, signed on November 27, 2006, or the U.S.-Belgium Tax Treaty, although there can be no assurance in this regard. Further, the IRS has determined that the U.S.-Belgium Tax Treaty is satisfactory for purposes of the qualified dividend rules and that it includes an exchange-of-information program. Therefore, subject to the discussion under "- Passive Foreign Investment Company Considerations" below, such dividends will generally be "qualified dividend income" in the hands of individual U.S. holders, provided that a holding period requirement (more than 60 days of ownership, without protection from the risk of loss, during the 121-day period beginning 60 days before the ex-dividend date) and certain other requirements are satisfied. The dividends will not be eligible for the dividends-received deduction generally allowed to corporate U.S. holders.

A U.S. holder generally may claim the amount of any Belgian withholding tax as either a deduction from gross income or a foreign tax credit against U.S. federal income tax liability. However, the foreign tax credit is subject to numerous complex limitations that must be determined and applied on an individual basis.

Generally, the credit cannot exceed the same proportion of a U.S. holder's U.S. federal income tax liability which such U.S. holder's "foreign source" taxable income bears to such U.S. holder's worldwide taxable income. In applying this limitation, a U.S. holder's various items of income and deduction must be classified, under complex rules, as either "foreign source" or "U.S. source." In addition, this limitation is calculated separately with respect to specific categories of income. The amount of a distribution with respect to the ordinary shares that is treated as a "dividend" may be lower for U.S. federal income tax purposes than it is for Belgian income tax purposes, potentially resulting in a reduced foreign tax credit for the U.S. holder. Furthermore, Belgian income taxes that are withheld in excess of the rate applicable under the U.S.-Belgium Tax Treaty or that are refundable under Belgian law will not be eligible for credit against a U.S. holder's U.S. federal income tax liability. U.S. Treasury Regulations that were finalized in 2022 may restrict the availability of foreign tax credits based on the nature of the tax imposed by the foreign jurisdiction. Each U.S. holder should consult its own tax advisors regarding the foreign tax credit rules.

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In general, the amount of a distribution paid to a U.S. holder in a foreign currency will be the dollar value of the foreign currency calculated by reference to the spot exchange rate on the day the U.S. holder receives the distribution, regardless of whether the foreign currency is converted into U.S. dollars at that time. Any foreign currency gain or loss a U.S. holder realizes on a subsequent conversion of foreign currency into U.S. dollars will be U.S. source ordinary income or loss. If dividends received in a foreign currency are converted into U.S. dollars on the day they are received, a U.S. holder should not be required to recognize foreign currency gain or loss in respect of the dividend.

***Sale, Exchange or Other Taxable Disposition of the Ordinary Shares***. A U.S. holder will generally recognize gain or loss for U.S. federal income tax purposes upon the sale, exchange or other taxable disposition of ordinary shares in an amount equal to the difference between the U.S. dollar value of the amount realized from such sale or exchange and the U.S. holder's tax basis for those ordinary shares. Subject to the discussion under "— Passive Foreign Investment Company Considerations" below, this gain or loss will generally be a capital gain or loss. The adjusted tax basis in the ordinary shares generally will be equal to the cost of such ordinary shares. Capital gain from the sale, exchange or other taxable disposition of ordinary shares of a non-corporate U.S. holder is generally eligible for a preferential rate of taxation applicable to capital gains, if the non-corporate U.S. holder's holding period determined at the time of such sale, exchange or other taxable disposition for such ordinary shares exceeds one year (i.e., such gain is a long-term capital gain). The deductibility of capital losses for U.S. federal income tax purposes is subject to limitations. Any such gain or loss that a U.S. holder recognizes generally will be treated as U.S. source income or loss for foreign tax credit limitation purposes.

For a cash basis taxpayer, units of foreign currency paid or received are translated into U.S. dollars at the spot rate on the settlement date of the purchase or sale. In that case, no foreign currency exchange gain or loss will result from currency fluctuations between the trade date and the settlement date of such a purchase or sale. An accrual basis taxpayer, however, may elect the same treatment required of cash basis taxpayers with respect to purchases and sales of the ordinary shares that are traded on an established securities market, provided the election is applied consistently from year to year. Such election may not be changed without the consent of the IRS. For an accrual basis taxpayer that does not make such an election, units of foreign currency paid or received are translated into U.S. dollars at the spot rate on the trade date of the purchase or sale. Such an accrual basis taxpayer may recognize exchange gain or loss based on currency fluctuations between the trade date and the settlement date. Any foreign currency gain or loss a U.S. holder realizes will be U.S. source ordinary income or loss.

***Net Investment Income Tax***. Certain U.S. holders that are individuals, estates or trusts are subject to a 3.8% tax on all or a portion of their "net investment income," which may include all or a portion of their dividend income and net gains from the disposition of ordinary shares. Each U.S. holder that is an individual, estate or trust is urged to consult its tax advisors regarding the applicability of the net investment income tax to its income and gains in respect of its investment in the ordinary shares.

***Passive Foreign Investment Company Considerations***. If we are a PFIC for any taxable year, a U.S. holder would be subject to special rules generally intended to reduce or eliminate any benefits from the deferral of U.S. federal income tax that a U.S. holder could derive from investing in a non-U.S. company that does not distribute all of its earnings on a current basis.

A corporation organized outside the United States generally will be classified as a PFIC for U.S. federal income tax purposes in any taxable year in which, after applying certain look-through rules with respect to the income and assets of its subsidiaries, either: (i) at least 75% of its gross income is "passive income" or (ii) at least 50% of the average quarterly value of its total gross assets (for which purpose, assuming we are treated as a publicly traded company pursuant to Section 1297(e)(3) of the Code, the total value of our assets may be determined in part by reference to the market value of its ordinary shares, which is subject to change) is attributable to assets that produce "passive income" or are held for the production of "passive income."

Passive income for this purpose generally includes dividends, interest, royalties, rents, gains from commodities and securities transactions, the excess of gains over losses from the disposition of assets which produce passive income, and includes amounts derived by reason of the temporary investment of cash, including the funds raised in offerings of the ordinary shares. If a non-U.S. corporation owns directly or indirectly at least 25% by value of the stock of another corporation, the non-U.S. corporation is treated for purposes of the PFIC tests as owning its proportionate share of the assets of the other corporation and as receiving directly its proportionate share of the other corporation's income for purposes of the PFIC tests. If we are classified as a PFIC for any year with respect to which a U.S. holder owns ordinary shares, we will generally continue to be treated as a PFIC with respect to such U.S. holder in all succeeding years during which the U.S. holder owns ordinary shares, regardless of whether we continue to meet the tests described above, unless we cease to meet the requirements for PFIC status and the U.S. holder makes the "deemed sale" election described below.

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Whether we are a PFIC for any taxable year will depend on the composition of our income and the projected composition and fair market values of our assets in each year, and because this is a factual determination made annually after the end of each taxable year, there can be no assurance that we will not be considered a PFIC for the current taxable year or any future taxable year. The market value of our assets is generally determined in large part by reference to the market price of the ordinary shares, which is likely to fluctuate. Based on the foregoing, with respect to our 2025 taxable year, we do not believe we were a PFIC and we do not anticipate that we will be a PFIC for the 2026 taxable year based upon the expected value of our assets, including any goodwill, and the expected composition of our income and assets. However, as previously mentioned, we cannot provide any assurances regarding our PFIC status for the current or future taxable years. Accordingly, our U.S. counsel expresses no opinion with respect to our PFIC status for the current or any future taxable year.

If we are a PFIC for any taxable year, then unless you make one of the elections described below, a special tax regime will apply to both (a) any "excess distribution" by us to you (generally, your ratable portion of distributions in any year which are greater than 125% of the average annual distribution received by you in the shorter of the three preceding years or your holding period for the ordinary shares), and (b) any gain realized on the sale or other disposition of the ordinary shares. Under this regime, any excess distribution and realized gain will be treated as ordinary income and will be subject to tax as if (a) the excess distribution or gain had been realized ratably over your holding period, (b) the amount deemed realized in each year had been subject to tax in each year of that holding period at the highest marginal rate for such year (other than income allocated to the current period or any taxable period before we became a PFIC, which would be subject to tax at the U.S. holder's regular ordinary income rate for the current year and would not be subject to the interest charge discussed below), and (c) the interest charge generally applicable to underpayments of tax had been imposed on the taxes deemed to have been payable in those years. In addition, dividend distributions made to you will not qualify for the lower rates of taxation applicable to long-term capital gains discussed above under "- Distributions."

If we are a PFIC for any year during which a U.S. holder holds our ordinary shares, we must generally continue to be treated as a PFIC by that U.S. holder for all succeeding years during which the U.S. holder holds our ordinary shares, unless we cease to meet the requirements for PFIC status and the U.S. holder makes a "deemed sale" election with respect to our ordinary shares. If such election is made, the U.S. holder will be deemed to have sold our ordinary shares it holds at their fair market value on the last day of the last taxable year in which we qualified as a PFIC, and any gain from such deemed sale would be subject to the consequences applicable to sales of PFIC shares described above. After the deemed sale election, the U.S. holder's ordinary shares with respect to which the deemed sale election was made will not be treated as shares in a PFIC unless we subsequently become a PFIC.

Certain elections exist that would result in an alternative treatment (such as mark-to-market treatment) of the ordinary shares. If a U.S. holder makes the mark-to-market election, the U.S. holder generally will recognize as ordinary income any excess of the fair market value of the ordinary shares at the end of each taxable year over their adjusted tax basis, and will recognize an ordinary loss in respect of any excess of the adjusted tax basis of the ordinary shares over their fair market value at the end of the taxable year (but only to the extent of the net amount of income previously included as a result of the mark-to-market election). If a U.S. holder makes the election, the U.S. holder's tax basis in the ordinary shares will be adjusted to reflect these income or loss amounts. Any gain recognized on the sale or other disposition of ordinary shares in a year when we are a PFIC will be treated as ordinary income and any loss will be treated as an ordinary loss (but only to the extent of the net amount of income previously included as a result of the mark-to-market election). The mark-to-market election is available only if we are a PFIC and our ordinary shares are "regularly traded" on a "qualified exchange." Our ordinary shares will be treated as "regularly traded" in any calendar year in which more than a de minimis quantity of our ordinary shares are traded on a qualified exchange on at least 15 days during each calendar quarter (subject to the rule that trades that have as one of their principal purposes the meeting of the trading requirement as disregarded). Nasdaq is a qualified exchange for this purpose and, consequently, if our ordinary shares are regularly traded, the mark-to-market election will be available to a U.S. holder. However, even if a U.S. holder validly makes a mark-to-market election with respect to our ordinary shares, the U.S. holder may continue to be subject to PFIC rules (described above) with respect to its indirect interest in any of our investments that are lower-tier PFICs (as defined below). In addition, it is possible that a mark-to-market election in our ordinary shares may result in a U.S. holder being taxed on the earnings and profits of a lower-tier PFIC that will result in a double counting of the same income.

The tax consequences that would apply if we were a PFIC would also be different from those described above if a U.S. holder were able to make a valid "qualified electing fund," or QEF, election. However, we do not currently intend to provide the information necessary for U.S. holders to make a QEF election if we were treated as a PFIC for any taxable year and prospective investors should assume that a QEF election will not be available. U.S. holders should consult their tax advisors to determine whether any of these above elections would be available and if so, what the consequences of the alternative treatments would be in their particular circumstances.

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If we are determined to be a PFIC, the general tax treatment for U.S. holders described in this section would apply to indirect distributions and gains deemed to be realized by U.S. holders in respect of any of our subsidiaries that also may be determined to be PFICs, or lower-tier PFICs.

If a U.S. holder owns ordinary shares during any taxable year in which we are a PFIC, the U.S. holder generally will be required to file an IRS Form 8621 (Information Return by a Shareholder of a Passive Foreign Investment Company or Qualified Electing Fund) with respect to the company and any lower-tier PFICs, generally with the U.S. holder's U.S. federal income tax return for that year. If our company were a PFIC for a given taxable year, then you should consult your tax advisor concerning your annual filing requirements.

**The U.S. federal income tax rules relating to PFICs are complex. Prospective investors are urged to consult their own tax advisers with respect to ownership and disposition of our ordinary shares, the consequences to them of an investment in a PFIC, any elections available with respect to our ordinary shares and the IRS information reporting obligations with respect to ownership and disposition of the ordinary shares.**

***Backup Withholding and Information Reporting***. U.S. holders generally will be subject to information reporting requirements with respect to dividends on ordinary shares and on the proceeds from the sale, exchange or disposition of ordinary shares that are paid within the United States or through U.S.-related financial intermediaries, unless the U.S. holder is an "exempt recipient." In addition, U.S. holders may be subject to backup withholding on such payments, unless the U.S. holder provides a correct taxpayer identification number and a duly executed IRS Form W-9 or otherwise establishes an exemption. Backup withholding is not an additional tax, and the amount of any backup withholding will be allowed as a credit against a U.S. holder's U.S. federal income tax liability and may entitle such holder to a refund, provided that the required information is timely furnished to the IRS.

***Foreign Asset Reporting***. Certain U.S. holders who are individuals and certain entities controlled by individuals may be required to report information relating to an interest in our ordinary shares, subject to certain exceptions (including an exception for shares held in accounts maintained by U.S. financial institutions) by filing IRS Form 8938 (Statement of Specified Foreign Financial Assets) with their U.S. federal income tax return. U.S. holders are urged to consult their tax advisors regarding their information reporting obligations, if any, with respect to their ownership and disposition of our ordinary shares.

**THE DISCUSSION ABOVE IS A GENERAL SUMMARY. IT DOES NOT COVER ALL TAX MATTERS THAT MAY BE OF IMPORTANCE TO A PROSPECTIVE INVESTOR. EACH PROSPECTIVE INVESTOR IS URGED TO CONSULT ITS OWN TAX ADVISOR ABOUT THE TAX CONSEQUENCES TO IT OF AN INVESTMENT IN ORDINARY SHARES IN LIGHT OF THE INVESTOR'S OWN CIRCUMSTANCES.**

#### Material Belgian Tax Consequences
The paragraphs below present a summary of certain material Belgian federal income tax consequences of the acquisition, ownership and disposal of ordinary shares by an investor, but does not address all tax consequences of the ownership and disposal of ordinary shares, and does not take into account the specific circumstances of particular investors, some of which may be subject to special rules, or the tax laws of any country other than Belgium. The following does not describe the tax treatment of investors that are subject to special rules, such as banks, insurance companies, collective investment undertakings, dealers in securities or currencies, persons that hold, or will hold, ordinary shares as a position in a straddle, share-repurchase transaction, conversion transactions, synthetic security or other integrated financial transactions. The summary is based on laws, treaties and regulatory interpretations in effect in Belgium on the date of this Annual Report, all of which are subject to change, including changes that could have retroactive effect. Investors should appreciate that, as a result of evolutions in law or practice, the eventual tax consequences may be different from what is stated below. In this respect, please note that the Belgian government has recently reached an agreement to implement certain tax reforms in Belgium but the final legal texts are not yet available with respect to the envisaged reforms. Each prospective investor is advised to consult its own tax advisor about the potential tax consequences of the envisaged tax reforms in Belgium on an investment by such Investor in ordinary shares.

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A Belgian resident is (i) an individual subject to Belgian personal income tax (i.e. an individual who has his domicile in Belgium or has the seat of his wealth in Belgium, or a person assimilated to a Belgian resident), (ii) a company subject to Belgian corporate income tax, i.e. a company that has its principal establishment, administrative seat or effective place of management in Belgium (and that is not excluded from the scope of the Belgian corporate income tax) (A company having its registered seat in Belgium shall be presumed, unless the contrary is proved, to have its principal establishment, administrative seat or effective place of management in Belgium), (iii) an Organization for Financing Pensions, or an OFP, subject to Belgian corporate income tax (i.e., a Belgian pension fund incorporated under the form of an OFP), or (iv) a legal entity subject to the Belgian tax on legal entities (i.e. a legal entity other than a company subject to the corporate income tax that has its principal establishment, administrative seat or effective place of management in Belgium). A Belgian non-resident is a person that is not a Belgian resident.

Investors are encouraged to consult their own advisers as to the tax consequences of the acquisition, ownership and disposal of the ordinary shares in light of their particular circumstances, including the effect of any state, local or other national laws.

#### Belgian taxation of dividends on ordinary shares
For Belgian income tax purposes, the gross amount of all distributions made by the company to its shareholders is generally taxed as a dividend distribution, except for the repayment of capital carried out in accordance with the Belgian Code on Companies and Associations to the extent that such repayment is imputed to the "fiscal" capital. The fiscal capital includes, in principle, the actual paid-up statutory capital and, subject to certain conditions, the paid issue premiums and the amounts subscribed to at the time of the issue of profit sharing certificates. Note that Article 18 of the Belgian Income Tax Code 1992, or ITC, provides that for any decision of capital reduction taken in accordance with the Belgian Code on Companies and Associations, the amount of the capital reduction will be deemed to be derived proportionally (a) from our fiscal capital, on the one hand and (b) on the other hand, from the total of (i) certain taxed reserves incorporated in our capital, (ii) certain taxed reserves not incorporated into our capital and (iii) certain untaxed reserves incorporated into our capital (it being understood that the imputation of the capital reduction on these different categories of reserves will be made in that order of priority). The part of the capital reduction that is deemed to be derived from the abovementioned taxed and untaxed reserves will be treated as a dividend distribution from a tax perspective and be subject to Belgian withholding tax, if applicable. The part of the capital reduction that is deemed to derive from the abovementioned untaxed reserves may additionally give rise to a corporate income tax charge at the level of the company.

In general, a Belgian withholding tax of (currently) 30% is levied on dividends.

In the case of a redemption of ordinary shares, the redemption price (after deduction of the part of the paid-up fiscal capital represented by the ordinary shares redeemed) will be treated as dividend that is subject to a Belgian withholding tax of 30%, subject to such relief as may be available under applicable domestic or tax treaty provisions. No withholding tax will be triggered if such redemption is carried out on a stock exchange and meets certain conditions. In the event of a liquidation, a withholding tax of 30% will be levied on any distributed amount exceeding the paid-up fiscal capital, subject to such relief as may be available under applicable domestic or tax treaty provisions.

Belgian tax law provides for certain exemptions from Belgian withholding tax on Belgian source dividends. If there is no exemption applicable under Belgian domestic tax law, the Belgian withholding tax can potentially be reduced or exempted for investors who are non-residents pursuant to the treaties regarding the avoidance of double taxation concluded between the Kingdom of Belgium and the state of residence of the non-resident shareholder (see below).

#### Belgian income tax
*Belgian resident individuals*

Belgian resident individuals who acquire and hold our ordinary shares as a private investment do not have to declare the dividend income in their personal income tax return since the 30% Belgian withholding tax fully discharges their personal income tax liability. If (and only if) the dividend income would be declared in the personal income tax return, it will be taxed at 30% or, if lower, at the progressive personal income tax rates applicable to the taxpayer's overall declared income. The first €833 (amount applicable for income year 2026 - tax year 2027) and per taxpayer of reported ordinary dividend income will be exempt from tax, subject to certain conditions. For the avoidance of doubt, all reported dividends (hence, not only dividends distributed on the shares) are taken into account to assess whether said maximum amount is reached.

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If the dividends are declared in the personal income tax return, the Belgian withholding tax paid can be credited against the final personal income tax liability of the investor and may also be reimbursed to the extent that it exceeds the final personal income tax liability, provided that the dividend distribution does not result in a reduction in value of, or capital loss on, the shares. The latter condition is not applicable if the Belgian individual can demonstrate that he has had full ownership of the ordinary shares during an uninterrupted period of 12 months prior to the attribution of the dividends.

Belgian resident individuals who acquire and hold the shares for professional purposes must always declare the dividend income in their personal income tax return and will be taxable at the individual's personal income tax rate (from 25% up to 50% depending on the bracket) increased with local surcharges. Withholding tax withheld at source may be credited against the personal income tax due and is reimbursable to the extent that it exceeds the personal income tax due, subject to two conditions: (i) the taxpayer must own the shares in full legal ownership on the day the beneficiary of the dividend is identified, and (ii) the dividend distribution may not result in a reduction in value of or a capital loss on the shares. The latter condition is not applicable if the individual can demonstrate that he has held the full legal ownership of the ordinary shares for an uninterrupted period of 12 months prior to the payment or attribution of the dividends.

*Belgian resident companies*

For Belgian resident companies, the dividend withholding tax does not fully discharge the corporate income tax liability. For such companies, the gross dividend income (including the Belgian withholding tax and excluding the foreign withholding tax, if any) must be declared in the corporate income tax return and will be added to their taxable income, which is, in principle, taxed at the ordinary corporate income tax rate of 25%. In certain circumstances and subject to certain conditions, a reduced corporate income tax rate of 20% applies to small companies and Medium Sized Enterprises (as defined by Article 1:24, §1 to §6 of the Belgian Code on Companies and Associations) on the first €100,000 of taxable profits.

Belgian resident companies can generally (although subject to certain conditions) deduct up to 100% of the gross dividend received from their taxable income, i.e. the dividend received deduction, provided that at the time of a dividend payment or attribution: (1) the Belgian resident company holds shares representing at least 10% of the share capital of the company or a participation in the company with an acquisition value of at least €2,500,000; (2) the shares have been held or will be held in full legal ownership for an uninterrupted period of at least one year (and, depending on the situation, need to be booked as a fixed financial asset by companies exceeding certain thresholds); and (3) the conditions relating to the taxation of the underlying distributed income, as described in article 203 of the ITC are met (together the "Conditions for the application of the dividend received deduction regime").

For qualifying investment companies (within the meaning of art. 2, §1, 5°, f) ITC), certain of the aforementioned conditions with respect to the dividend received deduction do not apply. The Conditions for the application of the dividend received deduction regime depend on a factual analysis and for this reason the availability of this regime should be verified upon each dividend distribution.

The Belgian withholding tax may, in principle, be credited against the Belgian corporate income tax due and is reimbursable to the extent that it exceeds such corporate income tax due, subject to the two following conditions: (i) the taxpayer must own the shares in full legal ownership on the day the beneficiary of the dividend is identified and (ii) the dividend distribution may not give rise to a reduction in the value of, or a capital loss on, the ordinary shares. The latter condition is not applicable if the company proves that it held the shares in full legal ownership during an uninterrupted period of 12 months prior to the attribution of the dividends or if, during that period, the shares never belonged to a taxpayer other than a resident company or a non-resident company which has, in an uninterrupted manner, invested the ordinary shares in a Belgian establishment.

No Belgian withholding tax will be due on dividends paid by us to a Belgian resident company provided that the resident company owns, at the time of the distribution of the dividend, at least 10% of our share capital for an uninterrupted period of at least one year and, provided further, that the resident company provides us or our paying agent with a certificate as to its status as a resident company and as to the fact that it has owned a 10% shareholding for an uninterrupted period of one year. For those companies owning a share participation of at least 10% in our share capital for less than one year, we will levy the withholding tax but will not transfer it to the Belgian Treasury provided that the Belgian resident company certifies its qualifying status, the date from which it has held such minimum participation, and its commitment to hold the minimum participation for an uninterrupted period of at least one year. The Belgian resident company must also inform us or our paying agent if the one-year period has expired or if its shareholding will drop below 10% of our share capital before the end of the one-year holding period. As soon as the investor owns the share participation of at least 10% in our capital for one year, it will receive the amount of this temporarily levied withholding tax.

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Please note that the above described dividend received deduction and withholding tax exemption will not be applicable to dividends which are connected to an arrangement or a series of arrangements ("rechtshandeling of geheel van rechtshandelingen"/"acte juridique ou un ensemble d'actes juridiques") for which the Belgian tax administration, taking into account all relevant facts and circumstances, has proven, unless evidence to the contrary, that this arrangement or this series of arrangements is not genuine ("kunstmatig"/"non authentique") and has been put in place for the main purpose or one of the main purposes of obtaining the dividend received deduction, the above dividend withholding tax exemption or one of the advantages of the EU Parent-Subsidiary Directive of 30 November 2011 (2011/96/EU), or Parent-Subsidiary Directive, in another EU Member State. An arrangement or a series of arrangements is regarded as not genuine to the extent that they are not put into place for valid commercial reasons which reflect economic reality.

*Belgian resident organizations for financing pensions*

For Belgian pension funds incorporated under the form of an Organization for Financing Pensions ("organismen voor de financiering van pensioenen"/"organismes de financement de pensions") within the meaning of article 8 of the Belgian Act of 27 October 2006, the dividend income from the ordinary shares is generally tax exempt.

Subject to certain limitations, any Belgian dividend withholding tax levied at source may be credited against the corporate income tax due and is reimbursable to the extent that it exceeds the corporate income tax due.

Belgian (or foreign) OFPs not holding the ordinary shares — which give rise to dividends — for an uninterrupted period of 60 days in full ownership amounts to a rebuttable presumption that the arrangement or series of arrangements ("rechtshandeling of geheel van rechtshandelingen"/"acte juridique ou un ensemble d'actes juridiques") which are connected to the dividend distributions, are not genuine ("kunstmatig"/"non authentique"). The withholding tax exemption will in such case not apply and/or any Belgian dividend withholding tax levied at source on the dividends will in such case not be credited against the corporate income tax, unless counterproof is provided by the OFP that the arrangement or series of arrangements are genuine (Article 281/1 ITC).

*Other Belgian resident legal entities subject to Belgian legal entities tax*

Belgian resident legal entities will be subject to the Belgian withholding tax on the dividends distributed by us. Under the current Belgian tax rules, Belgian withholding tax will represent the final tax liability and the dividends should, therefore, not be included in the tax returns of the legal entities.

*Non-resident individuals and companies*

For non-resident individuals and companies, the dividend withholding tax will be the only tax on dividends in Belgium, unless the non-resident holds the shares in connection with a business conducted in Belgium through a fixed base in Belgium or a Belgian permanent establishment.

If the ordinary shares are acquired by a non-resident in connection with a business in Belgium, the investor must report any dividends received, which will be taxable at the applicable non-resident individual or corporate income tax rate, as appropriate. Belgian withholding tax levied at source may be credited against non- resident individual or corporate income tax and is reimbursable to the extent that it exceeds the income tax due, subject to two conditions: (1) the taxpayer must own the shares in full legal ownership on the day the beneficiary of the dividend is identified and (2) the dividend distribution may not result in a reduction in value of or a capital loss on the shares. The latter condition is not applicable if (a) the non-resident individual or the non-resident company can demonstrate that the shares were held in full legal ownership for an uninterrupted period of 12 months prior to the payment or attribution of the dividends or (b) with regard to non-resident companies only, if, during the relevant period, the ordinary shares have not belonged to a taxpayer other than a resident company or a non-resident company which has, in an uninterrupted manner, invested the ordinary shares in a Belgian establishment.

Non-resident companies whose ordinary shares are invested in a Belgian permanent establishment may deduct 100% of the gross dividends received from their taxable income if, at the date the dividends are paid or attributed, the Conditions for the application of the dividend received deduction regime are met (see supra). Application of the dividend received deduction regime depends, however, on a factual analysis to be made upon each distribution and its availability should be verified upon each distribution.

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*Belgian dividend withholding tax relief for non-residents*

Dividends paid or attributed to non-resident individuals who do not use the ordinary shares in the exercise of a professional activity, may, subject to certain conditions and formalities, be eligible for the tax exemption with respect to ordinary dividends in an amount of up to €859 (amount applicable for income year 2025) per year and per taxpayer. For the avoidance of doubt, all dividends paid or attributed to such non-resident individual (and hence not only dividends paid or attributed on the ordinary shares) are taken into account to assess whether said maximum amount is reached. Consequently, if Belgian withholding tax has been levied on dividends paid or attributed to the ordinary shares, such non-resident individual may request in its Belgian non-resident income tax return that any Belgian withholding tax levied on up to such an amount be credited and, as the case may be, reimbursed. However, if no Belgian non- resident income tax return has to be filed by the non-resident individual, any Belgian withholding tax levied on up to such an amount could in principle be reclaimed by filing a request thereto addressed to the tax official ("Adviseur-generaal Centrum Buitenland"/"Conseiller-général du Centre Étranger") appointed by article 206/1 of the Royal Decree implementing the ITC. Such a request has to be made at the latest on December 31 of the calendar year following the calendar year in which the relevant dividend(s) have been received, together with an affidavit confirming the non-resident individual status and certain other formalities determined in the Royal Decree.

Belgian tax law provides for certain exemptions from withholding tax on Belgian source dividends distributed to non-resident investors. Under Belgian tax law, withholding tax is not due on dividends paid to a foreign pension fund which satisfies the following conditions: (i) it is a non-resident saver within the meaning of Article 227, 3° ITC which implies that it has separate legal personality and has its tax residence outside of Belgium; (ii) whose corporate purpose consists solely in managing and investing funds collected in order to pay legal or complementary pensions; (iii) whose activity is limited to the investment of funds collected in the exercise of its corporate purpose, without any profit making aim; (iv) which is exempt from income tax in its country of residence; and (v) provided that it is not contractually obliged to redistribute the dividends to any ultimate beneficiary of such dividends for whom it would manage the ordinary shares, nor obliged to pay a manufactured dividend with respect to the ordinary shares under a securities borrowing transaction. The exemption will only apply if the foreign pension fund provides a certificate confirming that it is the full legal owner or usufruct holder of the ordinary shares and that the above conditions are satisfied. The pension fund must then forward that certificate to us or our paying agent. As indicated above, Belgian (or foreign) OFPs not holding the ordinary shares — which give rise to dividends — for an uninterrupted period of 60 days in full ownership amounts to a rebuttable presumption that the arrangement or series of arrangements ("*rechtshandeling of geheel van rechtshandelingen"/"acte juridique ou un ensembled'actes juridiques*") which are connected to the dividend distributions, are not genuine ("*kunstmatig"/"non authentique*"). In such case the withholding tax exemption will not apply.

Dividends distributed to non-resident qualifying parent companies established in a Member State of the EU or in a country with which Belgium has concluded a double tax treaty that includes a qualifying exchange of information clause, will, under certain conditions, be exempt from Belgian withholding tax provided that the ordinary shares held by the non-resident company, upon payment or attribution of the dividends, amount to at least 10% of our share capital and such minimum participation is held or will be held during an uninterrupted period of at least one year. A non-resident company qualifies as a parent company provided that (i) for companies established in a Member State of the EU, it has a legal form as listed in the annex to the EU Parent-Subsidiary Directive, as amended from time to time, or, for companies established in a country with which Belgium has concluded a qualifying double tax treaty, it has a legal form similar to the ones listed in such annex; (ii) it is considered to be a tax resident according to the tax laws of the country where it is established and the double tax treaties concluded between such country and third countries; and (iii) it is subject to corporate income tax or a similar tax without benefiting from a tax regime that derogates from the ordinary tax regime. In order to benefit from this exemption, the non- resident company must provide us or our paying agent with a certificate confirming its qualifying status and the fact that it meets the required conditions.

If the non-resident company holds such a minimum participation for less than one year at the time the dividends are attributed to the ordinary shares, we must levy the withholding tax but do not need to transfer it to the Belgian Treasury provided that the non-resident company provides us or our paying agent with a certificate confirming, in addition to its qualifying status, the date as of which it has held the minimum participation, and its commitment to hold the minimum participation for an uninterrupted period of at least one year. The non-resident company must also inform us or our paying agent when the one-year period has expired or if its shareholding drops below 10% of our share capital before the end of the one year holding period. Upon satisfying the one-year holding requirement, the dividend withholding tax which was temporarily withheld, will be refunded to the non-resident company.

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Please note that the above withholding tax exemption will not be applicable to dividends which are connected to an arrangement or a series of arrangements ("rechtshandeling of geheel van rechtshandelingen"/"acte juridique ou un ensemble d'actes juridiques") for which the tax Belgian tax administration, taking into account all relevant facts and circumstances, has proven, unless evidence to the contrary, that this arrangement or this series of arrangements is not genuine ("kunstmatig"/"non authentique") and has been put in place for the main purpose or one of the main purposes of obtaining the dividend received deduction, the above dividend withholding tax exemption or one of the advantages of the Parent-Subsidiary Directive in another EU Member State. An arrangement or a series of arrangements is regarded as not genuine to the extent that they are not put into place for valid commercial reasons which reflect economic reality.

Dividends distributed by a Belgian company to non-resident companies on a share participation of less than 10% will under certain conditions be subject to an exemption from withholding tax, provided that the non- resident companies (i) are either established in another Member State of the EEA or in a country with which Belgium has concluded a double tax treaty, where that treaty, or any other treaty concluded between Belgium and that jurisdiction, includes a qualifying exchange of information clause; (ii) have a legal form as listed in Annex I, Part A to the Parent-Subsidiary Directive as amended from time to time, or a legal form similar to the legal forms listed in the aforementioned annex and which is governed by the laws of another Member State of the EEA or a similar legal form in a country with which Belgium has concluded a double tax treaty; (iii) hold a share participation in the Belgian dividend distributing company, upon payment or attribution of the dividends, of less than 10% of our share capital but with an acquisition value of at least €2.5 million (which may potentially also be increased to €4.0 million although this was not mentioned in the governmental agreement); (iv) hold or will hold the ordinary shares which give rise to the dividends in full legal ownership during an uninterrupted period of at least one year; and (v) are subject to the corporate income tax or a tax regime similar to the corporate income tax without benefiting from a tax regime which deviates from the ordinary regime. The exemption from withholding tax is only applied to the extent that the Belgian withholding tax, which would be applicable absent the exemption, could not be credited nor reimbursed at the level of the qualifying, dividend receiving, company. The non-resident company must provide us or our paying agent with a certificate confirming, in addition to its full name, legal form, address and fiscal identification number (if applicable), its qualifying status and the fact that it meets the required conditions mentioned under (i) to (v) above, and indicating to which extent the withholding tax, which would be applicable absent the exemption, is in principle creditable or reimbursable on the basis of the law as applicable on December 31 of the year preceding the year during which the dividend is paid or attributed.

If there is no exemption applicable under Belgian domestic tax law, the Belgian dividend withholding tax can potentially be reduced or exempted for investors who are non-residents pursuant to the treaties regarding the avoidance of double taxation concluded between the Kingdom of Belgium and the state of residence of the non-resident shareholder. Belgium has concluded tax treaties with more than 95 countries, reducing the dividend withholding tax rate to 15%, 10%, 5% or 0% for residents of those countries, depending on conditions, among others, related to the size of the shareholding and certain identification formalities.

Belgium and the United States have concluded a double tax treaty concerning the avoidance of double taxation (the "U.S. — Belgium Treaty"). The U.S. — Belgium Treaty reduces the applicability of Belgian withholding tax to 15%, 5% or 0% for U.S. taxpayers, provided that the U.S. taxpayer meets the limitation of benefits conditions imposed by the U.S. — Belgium Treaty. The Belgian withholding tax is generally reduced to 15% under the U.S. — Belgium Treaty. The 5% withholding tax applies in case where the U.S. shareholder (beneficial owner) is a company which owns directly at least 10% of our ordinary shares. A 0% Belgian withholding tax applies when the shareholder is a company (beneficial owner) which has owned directly at least 10% of our ordinary shares during at least 12 months, or is, subject to certain conditions, a U.S. pension fund. The U.S. shareholders are encouraged to consult their own tax advisers to determine whether they can invoke the benefits and meet the limitation of benefits conditions as imposed by the U.S. — Belgium Treaty.

Prospective holders are encouraged to consult their own tax advisers to determine whether they qualify for an exemption or a reduction of the withholding tax rate upon payment of dividends and, if so, the procedural requirements for obtaining such an exemption or a reduction upon the payment of dividends or making claims for reimbursement.

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#### Capital gains and losses on ordinary shares
*Belgian resident individuals*

Belgian resident individuals acquiring the ordinary shares as a private investment should not be subject to Belgian capital gains tax on the disposal of the ordinary shares and capital losses are not tax deductible (note however that a general capital gains tax of 10% was announced, which would take the form of a "solidarity contribution" – based on the current governmental agreement, the first €10,000 of capital gains would be exempt). However, capital gains realized by a private individual are taxable at 33% (plus local surcharges) if the capital gain is deemed to be realized outside the scope of the normal management of the individual's private estate. Capital losses incurred in such transactions are generally not tax deductible.

Capital gains realized by Belgian resident individuals on the disposal of the ordinary shares for consideration, outside the exercise of a professional activity, to a non-resident company (or a body constituted in a similar legal form), to a foreign state (or one of its political subdivisions or local authorities) or to a non-resident legal entity, each time established outside the EEA, are in principle taxable at a rate of 16.5% (plus local surcharges) if, at any time during the five years preceding the sale, the Belgian resident individual has owned directly or indirectly, alone or with his/her spouse or with certain relatives, a substantial shareholding in us (i.e., a shareholding of more than 25% in us). Capital losses are, however, not tax deductible in such event.

Capital gains realized by Belgian resident individuals upon redemption of the ordinary shares or upon our liquidation will generally be taxable as a dividend. See "— Belgian taxation of dividends on ordinary shares — Belgian income tax — Belgian resident individuals."

Belgian resident individuals who hold ordinary shares for professional purposes are taxed at the ordinary progressive income tax rates increased by the applicable local surcharges on any capital gains realized upon the disposal of the ordinary shares, except for the shares held for more than five years, which are taxable at a separate rate of 10% (capital gains realized in the framework of the cessation of activities under certain circumstances) or 16.5% (other), plus local surcharges. Capital losses on the shares incurred by Belgian resident individuals who hold the ordinary shares for professional purposes are in principle tax deductible.

*Belgian resident companies*

Belgian resident companies are normally not subject to Belgian capital gains taxation on gains realized upon the disposal of the ordinary shares provided that the Conditions for the application of the dividend received deduction regime are met. If one or more of the Conditions for the application of the dividend received deduction regime are not met, any capital gain realized would be taxable at the standard corporate income tax rate of 25%, unless the reduced corporate income tax rate of 20% for small companies and Medium Sized Enterprises applies (see supra).

Capital losses on the ordinary shares incurred by Belgian resident companies are as a general rule not tax deductible.

However, ordinary shares held in the trading portfolios of Belgian qualifying credit institutions, investment enterprises and management companies of collective investment undertakings are subject to a different regime. In general, the capital gains on such ordinary shares are taxable at the corporate income tax rate of 25% and capital losses on such ordinary shares are tax deductible. Internal transfers to and from the trading portfolio are assimilated to a realization.

Capital gains realized by Belgian resident companies upon redemption of the ordinary shares or upon our liquidation will, in principle, be subject to the same taxation regime as dividends.

*Belgian resident organizations for financing pensions*

Belgian pension funds incorporated under the form of an OFP are, in principle, not subject to Belgian capital gains taxation on the disposal of the ordinary shares, and capital losses are not tax deductible.

Capital gains realized by Belgian OFPs upon the redemption of ordinary shares or upon our liquidation will in principle be taxed as dividends.

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*Other Belgian resident legal entities subject to Belgian legal entities tax*

Capital gains realized upon disposal of the ordinary shares by Belgian resident legal entities are in principle not subject to Belgian income tax and capital losses are not tax deductible.

Capital gains realized upon disposal of (part of) a substantial participation in a Belgian company (i.e. a participation representing more than 25% of our share capital at any time during the last five years prior to the disposal) may, however, under certain circumstances be subject to income tax in Belgium at a rate of 16.5%.

Capital gains realized by Belgian resident legal entities upon redemption of the ordinary shares or upon our liquidation will, in principle, be subject to the same taxation regime as dividends (see above).

*Non-resident individuals, non-resident companies or non-resident entities*

Non-resident individuals, companies or entities are, in principle, not subject to Belgian income tax on capital gains realized upon disposal of the ordinary shares, unless the ordinary shares are held as part of a business conducted in Belgium through a fixed base in Belgium or a Belgian permanent establishment. In such a case, the same principles apply as described with regard to Belgian individuals (holding the ordinary shares for professional purposes), Belgian companies, Belgian resident organizations for financing pensions or other Belgian resident legal entities subject to Belgian legal entities tax.

Non-resident individuals who do not use the ordinary shares for professional purposes and who have their fiscal residence in a country with which Belgium has not concluded a tax treaty or with which Belgium has concluded a tax treaty that confers the authority to tax capital gains on the shares to Belgium, might be subject to tax in Belgium if the capital gains are obtained or received in Belgium and arise from transactions which are to be considered speculative or beyond the normal management of one's private estate or in case of disposal of a substantial participation in a Belgian company as mentioned in the tax treatment of the disposal of the ordinary shares by Belgian individuals (see supra – also with regard to the announced general capital gains tax). Such non-resident individuals might therefore be obliged to file a tax return and should consult their own tax adviser.

Capital gains realized by non-resident individuals or non-resident companies upon redemption of the ordinary shares or upon our liquidation will, in principle, be subject to the same taxation regime as dividends (see above).

#### Belgian Tax on Stock Exchange Transactions
A tax on stock exchange transactions ("Taxe sur les opérations de bourse"/"Taks op de beursverrichtingen") at the rate of 0.35% (subject to a maximum amount of EUR 1,600 per party and per transaction) will in principle be levied upon the sale and purchase and any other acquisition or transfer for consideration of the ordinary shares on the secondary market if (i) it is entered into or carried out in Belgium through a professional intermediary, or (ii) deemed to be entered into or carried out in Belgium, which is the case if the order is directly or indirectly made to a professional intermediary established outside of Belgium, either by private individuals with habitual residence ("gewone verblijfplaats"/"residence habituelle") in Belgium, or legal entities for the account of their seat or establishment in Belgium (both, a "Belgian Investor"). A separate tax is due from each of the seller and the purchaser, both collected by the professional intermediary. No tax on stock exchange transactions will be due on the issuance of the ordinary shares (primary market transaction).

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However, if the order is directly or indirectly made to a professional intermediary established outside of Belgium by a Belgian Investor, the tax on stock exchange transactions will in principle be due by this Belgian Investor (who will be responsible for the filing of a stock exchange tax return and for the timely payment of the amount of stock exchange tax due), unless that Belgian Investor can demonstrate that the tax on stock exchange transactions due has already been paid by the professional intermediary established outside of Belgium. In such a case, the foreign professional intermediary also has to provide each client (which gives such intermediary an order) with a qualifying order statement ("bordereau"/"borderel") at the latest on the business day after the day the transaction concerned was realized. The qualifying order statements must be numbered in series and a duplicate must be retained by the professional intermediary. The duplicate can be replaced by a qualifying day-to-day listing, numbered in series. Alternatively, professional intermediaries established outside of Belgium could appoint a stock exchange tax representative in Belgium, subject to certain conditions and formalities, or Stock Exchange Tax Representative. Such Stock Exchange Tax Representative will then be liable towards the Belgian Treasury for the tax on stock exchange transactions due on behalf of clients that fall within one of the aforementioned categories (provided that these clients do not qualify as exempt persons for stock exchange tax purposes — see below) and for complying with the reporting obligations and the obligations relating to the order statement ("bordereau"/"borderel") in that respect. If such a Stock Exchange Tax Representative would have paid the tax on stock exchange transactions due, the Belgian Investor will, as per the above, no longer be the debtor of the tax on stock exchange transactions.

No tax on stock exchange transactions is due on transactions entered into by the following parties, provided they are acting for their own account: (i) professional intermediaries described in article 2, 9° and 10° of the Belgian Law of 2 August 2002 on the supervision of the financial sector and financial services; (ii) insurance companies described in article 2, §1 of the Belgian Law of 9 July 1975 on the supervision of insurance companies; (iii) pension institutions referred to in article 2,1° of the Belgian Law of 27 October 2006 concerning the supervision of pension institutions; (iv) undertakings for collective investment; (v) regulated real estate companies; and (vi) Belgian non-residents provided they deliver a certificate to their financial intermediary in Belgium confirming their non-resident status.

As stated below, the tax on stock exchange transactions should be abolished once the FTT enters into force. The proposal is still subject to negotiation between the participating Member States and therefore may be changed at any time.

#### Other Income Tax Considerations
In addition to the income tax consequences discussed above, we may be subject to tax in one or more other jurisdictions where we conduct activities. The amount of any such tax imposed upon our operations may be material.

#### Annual tax on securities accounts
The tax on securities accounts is an annual tax of levied at a rate of 0.15% that is levied on securities accounts of which the average value of taxable financial instruments exceeds EUR 1 million during a reference period of twelve consecutive months (in principle) starting on October 1 and ending on September 30 of the subsequent year. The taxable base is determined based on four reference dates: December 31, March 31, June 30 and September 30. If applicable, the amount of tax due is limited to 10% of the difference between the said average value of the taxable financial instruments and the threshold of €1 million.

The tax targets securities accounts held by resident individuals subject to Belgian personal income tax, resident companies subject to Belgian corporate income tax, companies and resident legal entities subject to Belgian legal entities tax, irrespective as to whether these accounts are held with a financial intermediary which is established or located in Belgium or abroad. The tax also applies to securities accounts held by non-resident individuals, companies and legal entities with a financial intermediary established or located in Belgium (individuals, companies and legal entities subject to Belgian non-resident tax). Securities accounts that form part of the business property of a Belgian establishment of a non-resident as referred to in Article 229 ITC, wherever the intermediary is incorporated or established (in Belgium or abroad), are also subject to the annual tax. The financial instruments envisaged include not only shares, bonds and notes, but also derivatives. Each securities account would be assessed separately.

There are various exemptions, such as securities accounts held by specific types of regulated entities for their own account.

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A financial intermediary is defined as (i) the National Bank of Belgium, the European Central Bank and foreign central banks performing similar functions, (ii) a central securities depository included in article 198/1, §6, 12°ITC, (iii) a credit institution or a stockbroking firm as defined by Article 1, §3 of the Law of 25 April 2014 on the status and supervision of credit institutions and investment companies and (iv) the investment companies as defined by Article 3, §1 of the Law of 25 October 2016 on access to the activity of investment services and on the legal status and supervision of portfolio management and investment advice companies, which are, pursuant to national law, admitted to hold financial instruments for the account of customers.

A Belgian intermediary is an intermediary incorporated under Belgian law as well as an intermediary established in Belgium.

The Belgian intermediary in principle withholds, declares and pays the tax. In all other cases, the holder will declare and pay the tax himself, unless he can prove that the tax has already been declared and paid by an intermediary, irrespective as to whether the intermediary is incorporated or established in Belgium or abroad. When multiple holders hold a securities account, each holder may fulfil the declaration requirements for all holders and each holder shall be jointly and severally liable for the payment of the tax. An intermediary not incorporated or established in Belgium, when managing a securities account subject to the tax, may have a representative established in Belgium recognized by or on behalf of the Minister of Finance. The representative shall be jointly and severally liable towards to Belgian State to declare and pay the tax, as well as to perform all obligations to which an intermediary is bound.

The legislator introduced several anti-abuse provisions which apply retroactively as from 30 October 2020. This concerns a rebuttable general anti-abuse provision and two irrebuttable specific anti-abuse provisions. The latter covers the splitting of a securities account into multiple securities accounts held at the same intermediary and the conversion of taxable financial instruments held on a securities account, into registered financial instruments. On 27 October 2022, however, the Constitutional Court decided to annul the two irrebuttable specific anti-abuse provisions as well as the retroactive effect of the rebuttable general anti-abuse provision. The other provisions related to the annual tax on securities accounts were upheld by the Constitutional Court.

Investors are advised to consult their tax advisors about the consequences of the tax on securities accounts on their own tax situation.

#### Common Reporting Standard
Following recent international developments, the exchange of information is governed by the Common Reporting Standard, or CRS. On November 26, 2024, 125 jurisdictions have signed the multilateral competent authority agreement, or MCAA. The MCAA is a multilateral framework agreement to automatically exchange financial and personal information, with the subsequent bilateral exchanges coming into effect between those signatories that file the subsequent notifications.

49 jurisdictions, including Belgium, have committed to a specific and ambitious timetable leading to the first automatic information exchanges in 2017, relating to income year 2016, or early adopters. More than 50 jurisdictions have committed to exchange information as from 2018, one jurisdiction as from 2019, six jurisdictions as from 2020, two jurisdictions as from 2021 and three jurisdictions as from 2022.

Under CRS, financial institutions resident in a CRS country are required to report, according to a due diligence standard, financial information with respect to reportable accounts, which includes interest, dividends, account balance or value, income from certain insurance products, sales proceeds from financial assets and other income generated with respect to assets held in the account or payments made with respect to the account. Reportable accounts include accounts held by individuals and entities (which includes trusts and foundations) with fiscal residence in another CRS country. The standard includes a requirement to look through passive entities to report on the relevant controlling persons.

On December 9, 2014, EU Member States adopted Directive 2014/107/EU on administrative cooperation in direct taxation, or DAC2, which provides for mandatory automatic exchange of financial information as foreseen in CRS. DAC2 amends the previous Directive on administrative cooperation in direct taxation, Directive 2011/16/EU.

The mandatory automatic exchange of financial information by EU Member States as foreseen in DAC2 started as of September 30, 2017 (as of September 30, 2018 for Austria).

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The Belgian government has implemented said Directive 2014/107/EU, respectively the Common Reporting Standard, per the Law of December 16, 2015 regarding the exchange of information on financial accounts by Belgian financial institutions and by the Belgian tax administration, in the context of an automatic exchange of information on an international level and for tax purposes.

As a result of the Law of December 16, 2015, the mandatory automatic exchange of information applies in Belgium (i) as of income year 2016 (first information exchange in 2017) towards the EU Member States, (ii) as of income year 2014 (first information exchange in 2016) towards the US and (iii), with respect to any other non-EU States that have signed the MCAA, as of the respective date as determined by the Royal Decree of June 14, 2017. The Royal Decree provides that (i) for a first list of 18 countries, the mandatory exchange of information applies as of income year 2016 (first information exchange in 2017) and for a second list of 44 countries, the mandatory automatic exchange of information applies as of income year 2017 (first information exchange in 2018), (iii) as from 2019 (for the 2018 financial year) for another single jurisdiction, (iv) as from 2020 (for the 2019 financial year) for a fourth list of six jurisdictions, (v) as from 2023 (for the 2022 financial year) for 2 other jurisdictions and (vi) as from 2024 (for the 2023 financial year) for a sixth list of 4 jurisdictions.

Investors who are in any doubt as to their position should consult their professional advisers.

#### The proposed financial transactions tax
On February 14, 2013, the European Commission published a proposal, or the "Commission's Proposal, for a Directive for a common financial transaction tax, or FTT, to be levied on transactions in financial instruments by financial institutions if at least one of the parties to the transaction is located in the 'FTT- zone' as defined in the Commission's Proposal. It was approved by the European Parliament in July 2013. Originally, the adopted Commission's Proposal foresaw the financial transaction tax for 11 "Participating Member States" (Belgium, Germany, Estonia, Greece, Spain, France, Italy, Austria, Portugal, Slovenia and Slovakia). However, on March 16, 2016 Estonia formally withdrew from the group of states willing to introduce the FTT. The actual implementation date of the FTT would depend on the future approval of the European Council and consultation of other EU institutions, and the subsequent transposition into local law.

If the financial transaction tax is introduced, under current published proposals financial institutions and certain other parties would be required to pay tax on transactions in financial instruments with parties (including, with respect to the EU-wide proposal, its affiliates) located in the FTT-zone. The proposed FTT has very broad scope and could, if introduced in its current form, apply to certain dealings in the ordinary shares in certain circumstances. It is a tax on derivatives transactions (such as hedging activities) as well as on securities transactions, i.e. it applies to trading in instruments such as shares and bonds. The initial issue of instruments such as shares and bonds is exempt from financial transaction tax in the current Commission's Proposal. This means that the issuance and subscription of the ordinary shares should not become subject to financial transaction tax. Under current proposals the FTT could apply in certain circumstances to persons both within and outside of the participating Member States. Generally, it would apply to certain dealings in the ordinary shares where at least one party is a financial institution, and at least one party is established in a participating Member State. A financial institution may be, or be deemed to be, "established" in a participating Member State in a broad range of circumstances, including (a) by transacting with a person established in a participating Member State or (b) where the financial instrument which is subject to the dealings is issued in a participating Member State.

In 2019, Finance Ministers of the Member States participating in the enhanced cooperation indicated that they were discussing a new FTT proposal based on the French model of the tax and the possible mutualisation of the tax as a contribution to the EU budget.

According to the latest draft of this new FTT proposal (submitted by the German government), the FTT would be levied at a rate of at least 0.2 per cent. of the consideration for the acquisition of ownership of shares (including ordinary and any preference shares) admitted to trading on a trading venue or a similar third country venue, or of other securities equivalent to such shares, or Financial Instruments, or similar transactions (e.g. an acquisition of Financial Instruments by means of an exchange of Financial Instruments or by means of a physical settlement of a derivative). The FTT would be payable to the Participating Member State in whose territory the issuer of a Financial Instrument has established its registered office. According to the latest draft of the new FTT proposal, the FTT would not apply to straight notes. Like the Commission's Proposal, the latest draft of the new FTT proposal also stipulates that once the FTT enters into force, the Participating Member States shall not maintain or introduce taxes on financial transactions other than the FTT (or VAT as provided in the Council Directive 2006/112/EC of November 28, 2006 on the common system of value added tax).

As a consequence, Belgium should abolish the tax on stock exchange transactions once the FTT enters into force.

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In the framework of the Multiannual Financial Framework (MFF)/Own Resources negotiations, the European Parliament supported the introduction of the FTT as an Own Resource. The Commission agreed to issue a declaration as part of the overall political agreement. The Commission has recently clarified that "should there be an agreement on this Financial Transaction Tax, the Commission will make a proposal in order to transfer revenues from this Financial Transaction Tax to the EU budget as an own resource. If there is no agreement by end of 2022, the Commission will, based on impact assessments, propose a new own resource, based on a new Financial Transaction Tax. The Commission shall endeavour to make these proposals by June 2024 in view of its introduction by 1 January 2026".

In February 2021, EU Member States have been consulted on their current position regarding the FTT.

On 18 May 2021, the Commission again mentioned in a Communication that it will propose additional new own resources, which could include a Financial Transaction Tax.

However, the FTT Commission's Proposal remains subject to negotiation between the participating Member States. Further, its legality is at present uncertain. It may therefore be altered prior to any implementation, the timing of which remains unclear. Additional EU Member States may decide to participate. Prospective Noteholders are advised to seek their own professional advice in relation to the FTT.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;F. **Dividends and Paying Agents** 

Not Applicable.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;G. **Statement by Experts** 

Not Applicable.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;H. **Documents on Display** 

We are subject to the informational requirements of the Exchange Act. Accordingly, we are required to file reports and other information with the SEC, including annual reports on Form 20-F and reports on Form 6-K. You may inspect and copy reports and other information filed with the SEC at the Public Reference Room at 100 F Street, N.E., Washington, D.C. 20549. Information on the operation of the Public Reference Room may be obtained by calling the SEC at 1-800-732-0330. In addition, the SEC maintains an Internet website that contains reports and other information about issuers, like us, that file electronically with the SEC. The address of that website is www.sec.gov.

We also make available on our website, free of charge, our Annual Report and the text of our reports on Form 6-K, including any amendments to these reports, as well as certain other SEC filings, as soon as reasonably practicable after they are electronically filed with or furnished to the SEC. Our website address is www.nyxoah.com. The information contained on our website is not incorporated by reference in this Annual Report.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;I. **Subsidiary Information** 

Not Applicable.

#### Item 11. Quantitative and Qualitative Disclosures About Market Risk
Market risk is the risk that the fair value of future cash flows of a financial instrument will fluctuate because of changes in market prices. Our activities may expose us to changes in foreign currency exchange rates and interest rates. We are not exposed to any equity price risk or commodity price risk as we do not invest in these classes of investments.

#### Credit Risk
The credit risk arises mainly from trade receivables, cash and cash equivalents and deposits with banks and financial institutions. We only work with international reputable commercial banks and financial institutions.

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Furthermore, we are not exposed to any material credit risk as other receivables are mainly due by the governments in Australia and the Walloon Region and there is no risk associated to this receivable.

#### Foreign Exchange Risk
We are minimally exposed to currency risk on a limited number of expenses that are denominated in currencies other than the functional currency of our subsidiaries, primarily the U.S. dollar, or USD, Israeli new shekel, or NIS, or Australian dollars, or AUD.

Additionally, earnings variability arises from the translation of monetary assets and liabilities denominated in currencies other than the functional currency of subsidiaries at the rate of exchange at each closing date, the impact of which is reported as a foreign exchange gain or loss in the consolidated statements of comprehensive income. Most foreign exchange transactions were denominated in USD, NIS, or AUD for the subsidiaries that have functional currency in Euro. For the years ended December 31, 2025 and 2024, if the USD strengthened by 5% against the Euro with all other variables held constant, net loss for the year then ended would have been €130,000 and €87,000 higher, respectively. For the years ended December 31, 2025 and 2024, if the USD weakened by 5% against the Euro with all other variables held constant, net loss for the year then ended would have been €118,000 and €79,000 lower, respectively. For the years ended December 31, 2025 and 2024, if the NIS strengthened by 5% against the Euro with all other variables held constant, net loss for the years then ended would have been €35000 and €35,000 higher, respectively. For the years ended December 31, 2025 and 2024, if the NIS weakened by 5% against the Euro with all other variables held constant, net loss for the years then ended would have been €32,000 and €32,000 lower, respectively. For the years ended December 31, 2025 and 2024, if the AUD strengthened by 5% against the Euro with all other variables held constant, net loss for the years then ended would have been €29,000 and €22,000 higher, respectively. For the years ended December 31, 2025 and 2024, if the AUD weakened by 5% against the Euro with all other variables held constant, net loss for the years then ended would have been €27,000 and €20,000 lower, respectively.

We do not generally enter into arrangements to hedge our currency risk exposure.

#### Item 12. Description of Securities Other than Equity Securities
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A. **Debt Securities** 

Not Applicable.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;B. **Warrants and Rights** 

Not Applicable.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;C. **Other Securities** 

Not Applicable.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;D. **American Depositary Shares** 

Not Applicable.

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#### PART II

#### Item 13. Defaults, Dividend Arrearages and Delinquencies
None.

#### Item 14. Material Modifications to the Rights of Security Holders and Use of Proceeds

#### Initial Public Offering
In July 2021, we raised gross proceeds of $97.8 million in our initial public offering of 3,260,250 ordinary shares on The Nasdaq Global Market, which includes 425,250 ordinary shares issued in connection with the exercise of the underwriters' option to purchase additional shares, at a price of $30.00 per ordinary share.

The net proceeds to us, after deducting underwriting discounts and commissions and offering expenses, were approximately $91.9 million. The offering closed on July 7, 2021, and the closing of the exercise of the underwriters' option to purchase additional shares occurred on July 9, 2021. Piper Sandler, Stifel and Cantor acted as joint book-running managers for the offering. Degroof Petercam acted as a co-manager.

The net proceeds from our initial public offering on The Nasdaq Global Market have been used as described in the final prospectus for the global offering filed with the U.S. Securities and Exchange Commission on July 6, 2021. None of the net proceeds of our global offering were paid directly or indirectly to any director, officer, general partner of ours or to their associates, persons owning 10% or more of any class of our equity securities, or to any of our affiliates.

#### Item 15. Controls and Procedures
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**A.** **Disclosure Controls and Procedures** 

We maintain disclosure controls and procedures as such term is defined in Rules 13(a)-15(e) and 15(d)-15(e) under the Securities Exchange Act of 1934, as amended, or the Exchange Act, that are designed to ensure that information required to be disclosed in the reports that we file or submit under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the rules and forms of the Securities and Exchange Commission. Disclosure controls and procedures include, without limitation, controls and procedures designed to ensure that information required to be disclosed in our reports filed or submitted under the Exchange Act is accumulated and communicated to management, including our Chief Executive Officer and Chief Financial Officer, as appropriate, to allow timely decisions regarding required disclosure. Disclosure controls and procedures, no matter how well designed and operated, can only provide reasonable assurance of achieving the desired control objectives.

Our Chief Executive Officer (principal executive officer) and Chief Financial Officer (principal financial officer) have carried out an evaluation of the effectiveness of our disclosure controls and procedures as of December 31, 2025. Based on that evaluation, our Chief Executive Officer (principal executive officer) and Chief Financial Officer (principal financial officer) concluded that our disclosure controls and procedures were not effective as of December 31, 2025 due to the fact that the material weaknesses described below under "Management's Annual Report on Internal Control over Financial Reporting" continued to exist at December 31, 2025.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**B.** **Management's Annual Report on Internal Control over Financial Reporting** 

Our management is responsible for establishing and maintaining adequate internal control over financial reporting as defined in Rule 13a-15(f) under the Exchange Act. Our internal control over financial reporting is a process to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with IFRS as issued by the IASB. We have a program for the review of our internal control over financial reporting to ensure compliance with the requirements of the Exchange Act and Section 404 of the Sarbanes-Oxley Act. Because of its inherent limitations, internal control over financial reporting may not prevent or detect all misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

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As defined in the standards established by the PCAOB, a "material weakness" is a deficiency, or a combination of deficiencies, in internal control over financial reporting such that there is a reasonable possibility that a material misstatement of our annual or interim financial statements will not be prevented or detected on a timely basis.

Our management, under the supervision and with the participation of our Chief Executive Officer and Chief Financial Officer, conducted an evaluation of the effectiveness of the internal control over financial reporting as of December 31, 2025 using the criteria set forth by the Committee of Sponsoring Organizations of the Treadway Commission, or COSO, in Internal Control – Integrated Framework (2013).

Based on the evaluation performed, management concluded that the material weaknesses reported in previous years continued to exist as of December 31, 2025 and are related to:

● Insufficient accounting and supervisory personnel with the appropriate level of technical accounting experience and training, as well as a lack of sufficient personnel to carry out all control activities;

● Insufficient documented evidence of control implementation and execution in certain processes, including US operations, resulting in an inability to validate the design and operating effectiveness of our risk-based control assessment, which leads to insufficient procedures and controls, including IT General Controls, to ensure that accurate financial statements can be prepared and reviewed on a timely basis for annual reporting purposes.

While our management has taken, and continues to take, steps to remediate the material weaknesses, the material weaknesses have not yet been resolved as of December 31, 2025, and remediation is ongoing as described below. As a result of the material weaknesses described above that have not yet been resolved as of December 31, 2025, we have concluded that our internal control over financial reporting was not effective as of December 31, 2025.

**Remediation Actions During 2025**

To address the material weaknesses identified, our management has taken, and continues to take, several remedial actions in 2025 in accordance with its remediation roadmap. During 2025, we continued to adapt our internal control framework based on audit committee reports and auditor findings. We closely monitored and followed up with control owners to ensure the effective execution of controls, and onboarded a third party service provider to support control owners in performing control activities and assessing the adequacy of control design? We also organized a SOX readiness assessment with our auditors to further strengthen control execution and are currently reviewing the execution of higher risk controls to minimize the risk of financial statement adjustments.

In addition, during 2025 we further integrated controlling processes within our ERP system, updated the design of controls to reflect changes in our organizational structure and ERP environment, and maintained and further consolidated our internal control framework within our Governance, Risk and Compliance tool to support ongoing monitoring and execution of controls. In addition, during 2025 we invested in Sarbanes-Oxley training and education for relevant personnel and control owners to enhance technical knowledge and support consistent execution of controls, and we expect to continue to invest in such training in future periods.

To address the Customer to Cash in Nyxoah Inc, we organized at year end 2025 process workshops and established detailed process narratives to document and strengthen this critical process. The timing of certain remediation activities has been influenced by significant operational and strategic milestones during the period, including activities related to FDA approval, capital-raising initiatives and the preparation for and commencement of commercialization activities. While our US Customer to cash design documentation may have taken time to be finalized, we were methodical in making sure US revenue was accurately, timely and completely booked especially since it was Nyxoah Inc first quarter of sales in the US. These events required increased management attention and allocation of resources. Notwithstanding these factors, management continued to advance its remediation efforts and remains committed to the timely implementation and enhancement of its internal control over financial reporting.

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**Ongoing and Future Initiatives for 2026**

To continue the remediation efforts, and if all other factors remain equal, we expect to further improve our internal control framework. These improvements include challenging and reviewing the operating effectiveness of controls, and extending the control framework to support U.S. operations. In Q1 2026, the control & process deliverables were further detailed out with the US team to map out the full design of key controls in this process In addition, we plan to further enhance our IT general controls, by strengthening including controls and enhance existing documentation and monitoring of existing controls related to user access restrictions and segregation of duties, and by implementing a global IT ticketing tool and other technology enhancements to support SOX-relevant processes. These actions are also intended to support our preparation for our first integrated audit, which we will take place in 2026.

The process of designing and implementing an effective financial reporting system is a continuous effort that requires us to anticipate and react to changes in our business and the economic and regulatory environments and to expend significant resources to maintain a financial reporting system that is adequate to satisfy our reporting obligations. Our failure to correct these material weaknesses or our failure to discover and address any other control deficiencies could result in inaccuracies in our financial statements and could also impair our ability to comply with applicable financial reporting requirements and make related regulatory filings on a timely basis. As a result, our business, financial condition, results of operations and prospects, as well as the trading price of our ordinary shares, may be materially and adversely affected.

Notwithstanding these material weaknesses and management's assessment that internal control over financial reporting was ineffective as of December 31, 2025, our management, including our Chief Executive Officer (principal executive officer) and Chief Financial Officer (principal financial officer), believes that the consolidated financial statements contained in this Annual Report present fairly, in all material respects, our financial position, results of operations and cash flows for the periods presented in conformity with IFRS.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**C.** **Attestation Report of the Registered Public Accounting Firm** 

This Annual Report does not include a report from our Registered Public Accounting Firm regarding internal control over financial reporting due to our Emerging Growth Company status and due to the transition period established by rules of the SEC for newly public companies.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**D.** **Changes in Internal Control Over Financial Reporting** 

Except for the changes described above, there have been no changes in the Group's internal control over financial reporting that have occurred during the period covered by this Annual Report on Form 20-F, that have materially affected or are reasonably likely to materially affect our internal control over financial reporting.

#### Item 16A. Audit Committee Financial Expert
Our Audit Committee is comprised of three of our non-executive directors, Kevin Rakin (Chairman), Jürgen Hambrecht and Wildman Ventures LLC, as represented by Daniel Wildman, and each of these members is an "independent director" as such term is defined in Rule 10A-3 under the Exchange Act and under the listing standards of Nasdaq. Mr. Rakin serves as chair of this committee. Our Board has determined that Mr. Rakin is an "audit committee financial expert" as defined in Item 16A of Form 20-F.

#### Item 16B. Code of Ethics
Our Corporate Code of Conduct and Ethics and Whistleblower Policy is applicable to all of our employees, officers and directors and is available on our website at http://www.nyxoah.com and included as Exhibit 11.1 herein. We expect that any amendment to this code, or any waivers of its requirements, will be disclosed on our website. Information contained on, or that can be accessed through, our website is not incorporated by reference into this Annual Report, and you should not consider information on our website to be part of this Annual Report.

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#### Item 16C. Principal Accountant Fees and Services
Our financial statements have been prepared in accordance with IFRS and are audited by EY Reviseurs d'Entreprises / EY Bedrijfsrevisoren SRL/BV,

EY Reviseurs d'Entreprises / EY Bedrijfsrevisoren SRL/BV has served as our independent registered public accountant for each of the years ended December 31, 2023, December 31, 2024 and December 31, 2025 for which audited statements appear in this Annual Report.

The following table shows the aggregate fees billed to us, including some of our subsidiaries, for services rendered by EY Reviseurs d'Entreprises / EY Bedrijfsrevisoren SRL/BV.

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **Year ended December 31,**  | **Year ended December 31,**  | **Year ended December 31,**  | **Year ended December 31,**  |
|  | **2025** | **2025** | **2024** | **2024** |
|  | **(in thousands)** | **(in thousands)** | **(in thousands)** | **(in thousands)** |
| Audit Fees(1) | € | 1104 | € | 748 |
| Tax Fees(2) |  | 13 |  | 10 |
| **Total** | **€** | 1117 | **€** | 758 |

---

&nbsp;&nbsp;&nbsp;&nbsp;(1) Audit Fees are primarily for audit services including SEC filings, comfort letters, consents and Assistance with and review of documents filed with the SEC.

&nbsp;&nbsp;&nbsp;&nbsp;(2) Tax Fees are the aggregate fees billed for professional services rendered by the principal accountant for tax compliance, tax advice and tax planning related services.

Our Audit Committee reviews and pre-approves the scope and the cost of audit services related to us and permissible non-audit services performed by the independent auditors, other than those for de minimis services which are approved by the Audit Committee prior to the completion of the audit. All of the services (100%) related to our company provided by EY Reviseurs d'Entreprises / EY Bedrijfsrevisoren SRL/BV during the last two fiscal years have been approved by the Audit Committee in accordance with Regulation S-X, Rule 2-01, paragraph (c)(7)(i).

#### Item 16D. Exemptions From the Listing Standards For Audit Committees
Not Applicable.

#### Item 16E. Purchases of Equity Securities by the Issuer and Affiliated Purchasers
Not Applicable.

#### Item 16F. Change in the Registrant's Certifying Accountant
Not Applicable.

#### Item 16G. Corporate Governance
The listing rules of the Nasdaq Stock Market include certain accommodations in the corporate governance requirements that allow foreign private issuers, to follow "home country" corporate governance practices in lieu of the otherwise applicable corporate governance standards of the Nasdaq Stock Market. The application of such exceptions requires that we disclose each noncompliance with the Nasdaq Stock Market listing rules that we do not follow and describe the Belgian corporate governance practices we do follow in lieu of the relevant Nasdaq Stock Market corporate governance standard.

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We intend to continue to follow Belgian corporate governance practices in lieu of the corporate governance requirements of the Nasdaq Stock Market in respect of the following:

● Quorum at Shareholder Meetings. Nasdaq Stock Market Listing Rule 5620(c) requires that for any meeting of shareholders, the quorum must be no less than 33.33% of the outstanding ordinary shares. There is no general quorum requirement under Belgian law for ordinary meetings of shareholders, except in relation to decisions regarding certain matters.

● Compensation Committee and Nomination Committee. Nasdaq Stock Market Listing Rule 5605(d)(2) requires that compensation of officers must be determined by, or recommended to, the board of directors for determination, either by a majority of the independent directors, or a compensation committee comprised solely of independent directors. Nasdaq Stock Market Listing Rule 5605(e) requires that director nominees be selected, or recommended for selection, either by a majority of the independent directors or a nominations committee comprised solely of independent directors. Under Belgian law, we are not subject to any such requirements. In particular, we are not required by Belgian law to set up any compensation or nominations committees within our board of directors, and are therefore not subject to any Belgian legal requirements as to the composition of such committees either. However, our articles of association provide that our board of directors may form committees from among its members. Our board of directors has set up and appointed a nomination committee and a remuneration committee. Pursuant to article 7:100 of the Belgian CCA, only a majority of the members of the remuneration committee should in principle meet the independence criteria referred to in article 7:87 of the Belgian CCA and set out in provision 3.5 of the Belgian Code on Corporate Governance. Pursuant to provision 4.19 of the Belgian Code on Corporate Governance, only a majority of the members of the remuneration committee must qualify as independent.

● Independent Director Majority. Nasdaq Stock Market Listing Rules 5605(b)(1) and (2) require that a majority of the board of directors must be comprised of independent directors and that independent directors must have regularly scheduled meetings at which only independent directors are present. We are not required under Belgian law to have a majority of independent directors on our board of directors. However, our articles of association provide that our board of directors must be comprised of at least three directors, of which, pursuant to our corporate governance charter and provision 3.4 of the Belgian Code on Corporate Governance, at least three directors must be independent directors under Belgian law. We do not require our independent directors to meet separately from the full board of directors on a regular basis or at all.

● Executive Session. NASDAQ Stock Market Listing Rule 5605(b)(2) requires that independent directors must have regularly scheduled meetings at which only independent directors are present. We do not require our independent directors to meet separately from the full board of directors on a regular basis or at all, although the board of directors is supportive of its independent members voluntarily arranging to meet separately from the other members of our board of directors when and if they wish to do so.

● Charters. NASDAQ Stock Market Listing Rules 5605(c)(1), (d)(1) and (e)(2) require that each committee of the board of directors must have a formal written charter. Pursuant to the Belgian Corporate Governance Code, our board of directors has drawn up a corporate governance charter including, amongst others, the internal rules of our committees.

● Shareholder Approval of Issuance. NASDAQ Stock Market Listing Rule 5635 provides that an issuer listed on the NASDAQ Global Market is required to obtain shareholder approval in accordance with NASDAQ Rule 5635 as a prerequisite to approval of applications to list additional shares when the additional shares will be issued in connection with a transaction involving the sale, issuance, or potential issuance by the issuer of ordinary shares (or securities convertible into ordinary shares) equal to 20% or more of its presently outstanding common shares (or securities convertible into common shares) for less than the greater of book or market value of the shares, or the 20% Rule, or when the issuance or potential issuance of additional shares will result in a change of control of the issuer, including, but not limited to, those issuances that constitute a reverse merger, or the Change of Control Rule. The laws of Belgium do not require shareholder approval prior to any of the foregoing types of issuances and the Company has elected to follow its home country rules with respect to NASDAQ Rule 5635.

We may in the future decide to use the foreign private issuer exemption with respect to some or all of the other NASDAQ corporate governance rules. We also intend to comply with the Belgian corporate governance requirements under the Belgian Corporate Governance Code. Following our home country governance practices, as opposed to the requirements that would otherwise apply to a company listed on Nasdaq, may provide less protection than is accorded to investors under Nasdaq listing requirements applicable to domestic issuers. For more information, see "Risk Factors—Risks Related to the Ordinary Shares—As a foreign private issuer and as permitted by the listing requirements of Nasdaq, we rely on certain home country corporate governance practices rather than the corporate governance requirements of Nasdaq."

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Our directors and senior management are subject to the reporting requirements of Section 16(a) of the exchange act and Section 13 of the Exchange Act (as applicable), but they are not subject to eh short-swing profit recovery provisions of Section 16(b) or the short-sale restrictions of Section 16(a) of the Exchange Act.

#### Item 16H. Mine Safety Disclosure
Not Applicable.

#### Item 16I. Disclosure Regarding Foreign Jurisdictions That Prevent Inspections
Not Applicable.

#### Item 16J. Insider Trading Policy
Our Insider Trading Policy is included in our Corporate Code of Conduct and Ethics and Whistleblower Policy and is applicable to all of our employees, officers and directors. Our Insider Trading Policy governs the purchase, sale, and other dispositions of our securities by our employees, officers and directors and is designed to promote compliance with insider trading laws and rules and regulations, and any listing standards applicable to us. A copy of our Insider Trading Policy is included in our Corporate Code of Conduct and Ethics and Whistleblower Policy that is available on our website at http://www.nyxoah.com and filed as an exhibit to this Annual Report.

#### Item 16K. Cybersecurity
We recognize the critical importance of maintaining the trust and confidence of customers, patients, business partners and employees toward our business and are committed to protecting the confidentiality, integrity and availability of our business operations and systems. Our board of directors is involved in oversight of our risk management activities, and cybersecurity represents an important element of our overall approach to risk management. Our cybersecurity policies, standards, processes and practices are based on recognized frameworks established by the National Institute of Standards and Technology, or NIST, and other applicable industry standards. In general, we seek to address cybersecurity risks through a comprehensive, cross-functional approach that is focused on preserving the confidentiality, security and availability of the information that we collect and store by identifying, preventing and mitigating cybersecurity threats and effectively responding to cybersecurity incidents when they occur.

***Cybersecurity Risk Management and Strategy; Effect of Risk***

We face risks related to cybersecurity such as unauthorized access, cybersecurity attacks and other security incidents, including as perpetrated by hackers and unintentional damage or disruption to hardware and software systems, loss of data, and misappropriation of confidential information. To identify and assess material risks from cybersecurity threats, we maintain a comprehensive cybersecurity program to ensure our systems are effective and prepared for information security risks, including regular oversight of our programs for security monitoring for internal and external threats to ensure the confidentiality and integrity of our information assets. We consider risks from cybersecurity threats alongside other company risks as part of our overall risk assessment process. We employ a range of tools and services, including regular network and endpoint monitoring, audits, vulnerability assessments and threat modeling to inform our risk identification and assessment. As discussed in more detail under "Cybersecurity Governance" below, our board of directors provides oversight of our cybersecurity risk management and strategy processes, which are led by our Chief Financial Officer.

We also identify our cybersecurity threat risks by comparing our processes to standards set by the National Institute of Standards and Technology, or NIST. To provide for the availability of critical data and systems, maintain regulatory compliance, manage our material risks from cybersecurity threats, and protect against and respond to cybersecurity incidents, we undertake the following activities:

● monitor emerging data protection laws and implement changes to our processes that are designed to comply with such laws;

● through our policies, practices and contracts (as applicable), require employees, as well as third parties that provide services on our behalf, to treat confidential information and data with care;

● employ technical safeguards that are designed to protect our information systems from cybersecurity threats, including firewalls, intrusion prevention and detection systems, anti-malware functionality and access controls, which are evaluated and improved through vulnerability assessments and cybersecurity threat intelligence;

[**Table of Contents**](#TOC)

● provide regular, mandatory training for our employees and contractors regarding cybersecurity threats as a means to equip them with effective tools to address cybersecurity threats, and to communicate our evolving information security policies, standards, processes and practices;

● conduct cybersecurity management and incident training for employees involved in our systems and processes that handle sensitive data;

● leverage the NIST incident handling framework to help us identify, protect, detect, respond and recover when there is an actual or potential cybersecurity incident; and

● carry information security risk insurance that provides protection against the potential losses arising from a cybersecurity incident.

Our incident response plan coordinates the activities we take to prepare for, detect, respond to and recover from cybersecurity incidents, which include processes to triage, assess severity for, escalate, contain, investigate and remediate the incident, as well as to comply with potentially applicable legal obligations and mitigate damage to our business and reputation.

Our processes also address cybersecurity threat risks associated with our use of third-party service providers, including our suppliers and manufacturers or who have access to patient and employee data or our systems. In addition, cybersecurity considerations affect the selection and oversight of our third-party service providers. We perform diligence on third parties that have access to our systems, data or facilities that house such systems or data, and continually monitor cybersecurity threat risks identified through such diligence. Additionally, we generally require those third parties that could introduce significant cybersecurity risk to us to agree by contract to manage their cybersecurity risks in specified ways, and to agree to be subject to cybersecurity audits, which we conduct as appropriate.

We describe whether and how risks from identified cybersecurity threats, including as a result of any previous cybersecurity incidents, have materially affected or are reasonably likely to materially affect us, including our business strategy, results of operations, or financial condition, under the heading "We rely significantly on information technology and any failure, inadequacy, interruption or security lapse of that technology or loss of data, including any cyber security incidents, could compromise sensitive information related to our business, prevent us from accessing critical information or expose us to liability which could harm our ability to operate our business effectively and adversely affect our business and reputation," which disclosures are incorporated by reference herein.

We have not experienced any material cybersecurity incidents and the expenses we have incurred from cybersecurity incidents were immaterial.

***Cybersecurity Governance; Management***

Cybersecurity is an important part of our risk management processes and an area of focus for our board of directors and management. Our board of directors, as assisted by our science and technology committee, is responsible for the oversight of risks from cybersecurity threats.

Our board of directors and science and technology committee receive updates from management of our cybersecurity threat risk management and strategy processes covering topics such as data security posture, progress towards pre-determined risk-mitigation-related goals, and material cybersecurity threat risks or incidents and developments, as well as the steps management has taken to respond to such risks. Our board of directors and science and technology committee also receive prompt and timely information regarding any material cybersecurity incident, as well as ongoing updates regarding any such incident until it has been addressed.

Our cybersecurity risk management and strategy processes, which are discussed in greater detail above, are led by our Chief Financial Officer. Our Chief Financial Officer is informed about and monitors the prevention, mitigation, detection, and remediation of cybersecurity incidents through his management of, and participation in, the cybersecurity risk management and strategy processes described above. As discussed above, our Chief Financial Officer reports to our board of directors and science and technology committee about cybersecurity threat risks, among other cybersecurity related matters.

[**Table of Contents**](#TOC)

#### PART III

---

| | |
|:---|:---|
| **Item 17.** | **Financial Statements** |

---

We have elected to provide financial statements pursuant to Item 18.

#### Item 18. Financial Statements
The financial statements are filed as part of this Annual Report beginning on page F-1.

#### Item 19. Exhibits

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| <br>**Exhibit**  | &nbsp;&nbsp;<br>**Description** | &nbsp;&nbsp;<br>**Schedule/Form** | &nbsp;&nbsp;<br>**FileNumber** | &nbsp;&nbsp;<br>**Exhibit** | &nbsp;&nbsp;<br>**FileDate** |
| **1.1\*** | [Articles of Association of Nyxoah SA (English Translation)](nyxh-20251231xex1d1.htm) |  |  |  |  |
| **2.1\*** | [Articles of Association of Nyxoah SA (English Translation) (included in Exhibit 1.1)](nyxh-20251231xex1d1.htm) |  |  |  |  |
| **2.2** | [Description of Securities](https://www.sec.gov/Archives/edgar/data/1857190/000110465924036688/nyxh-20231231xex2d2.htm) | Form 20-F | &nbsp;&nbsp;001-40552 | &nbsp;&nbsp;2.2 | &nbsp;&nbsp;3/20/2024 |
| **4.1+** | [Cochlear Collaboration Agreement, dated November 2018, by and between the registrant and Cochlear Limited](https://www.sec.gov/Archives/edgar/data/1857190/000110465921079516/tm2111148d7_ex10-1.htm) | Form F-1 | &nbsp;&nbsp;333-257000 | &nbsp;&nbsp;10.1 | &nbsp;&nbsp;6/10/2021 |
| **4.2+** | [Man& Science SA License Agreement, by and between the registrant and Cephalix SA, Glucobel SA, Surgical Electronics SA and Man& Science SA, among others, as amended by the Confirmatory Addendum to the Multiparty Agreement, dated as of June 23, 2016, by and between the registrant and Cephalix SA, Surgical Electronics SA and Man& Science SA and as further amended by the Clarification of the Confirmatory Addendum to the Multiparty Agreement, dated as of February 10, 2020, by and between the registrant and Man& Science SA.](https://www.sec.gov/Archives/edgar/data/1857190/000110465921079516/tm2111148d7_ex10-2.htm) | Form F-1 | &nbsp;&nbsp;333-257000 | &nbsp;&nbsp;10.2 | &nbsp;&nbsp;6/10/2021 |
| **4.3+** | [Unprotected Lease Contract, dated as of August 20, 2020, by and between Nyxoah Ltd. and Block 7093 Parcel 162 Ltd. (English Translation)](https://www.sec.gov/Archives/edgar/data/1857190/000110465921079516/tm2111148d7_ex10-3.htm) | Form F-1 | &nbsp;&nbsp;333-257000 | &nbsp;&nbsp;10.3 | &nbsp;&nbsp;6/10/2021 |
| **4.4#** | [Form of 2013 Share Incentive Plan (English Translation)](https://www.sec.gov/Archives/edgar/data/1857190/000110465921079516/tm2111148d7_ex10-4.htm) | Form F-1 | &nbsp;&nbsp;333-257000 | &nbsp;&nbsp;10.4 | &nbsp;&nbsp;6/10/2021 |
| **4.5#** | [Form of 2016 Warrants Plan (English Translation)](https://www.sec.gov/Archives/edgar/data/1857190/000110465921079516/tm2111148d7_ex10-5.htm) | Form F-1 | &nbsp;&nbsp;333-257000 | &nbsp;&nbsp;10.5 | &nbsp;&nbsp;6/10/2021 |
| **4.6#** | [Form of 2018 Warrants Plan (English Translation)](https://www.sec.gov/Archives/edgar/data/1857190/000110465921079516/tm2111148d7_ex10-6.htm) | Form F-1 | &nbsp;&nbsp;333-257000 | &nbsp;&nbsp;10.6 | &nbsp;&nbsp;6/10/2021 |
| **4.7#** | [Form of 2020 Warrants Plan (English Translation)](https://www.sec.gov/Archives/edgar/data/1857190/000110465921079516/tm2111148d7_ex10-7.htm) | Form F-1 | &nbsp;&nbsp;333-257000 | &nbsp;&nbsp;10.7 | &nbsp;&nbsp;6/10/2021 |
| **4.8#** | [Form of 2021 Warrants Plan (English Translation)](https://www.sec.gov/Archives/edgar/data/1857190/000110465921141913/tm2133261d1_99-5.htm) | Form S-8 | &nbsp;&nbsp;333-257000 | &nbsp;&nbsp;99.5 | &nbsp;&nbsp;19/11/2021 |
| **4.9#** | [Form of 2022 Warrants Plan (English Translation)](https://www.sec.gov/Archives/edgar/data/1857190/000110465923006563/tm234202d1_ex99-1.htm) | Form S-8 | &nbsp;&nbsp;333-257000 | &nbsp;&nbsp;99.1 | &nbsp;&nbsp;25/01/2023 |

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| | | | | | |
|:---|:---|:---|:---|:---|:---|
| <br>**Exhibit**  | &nbsp;&nbsp;<br>**Description** | &nbsp;&nbsp;<br>**Schedule/Form** | &nbsp;&nbsp;<br>**FileNumber** | &nbsp;&nbsp;<br>**Exhibit** | &nbsp;&nbsp;<br>**FileDate** |
| **4.10** | [Sales Agreement, dated as of December 22, 2022, by and between Nyxoah SA and Cantor Fitzgerald & Co.](https://www.sec.gov/Archives/edgar/data/1857190/000110465922129515/tm2232874d2_ex1-2.htm) | Form 20-F | 001-40552 | 4.10 | 3/20/2024 |
| **4.11** | [First Addendum, dated November 15, 2023, to Unprotected Lease Contract, by and between Nyxoah Ltd. and Block 7093 Parcel 162 Ltd. (English Translation)](https://www.sec.gov/Archives/edgar/data/1857190/000110465924036688/nyxh-20231231xex4d11.htm) | Form 20-F | 001-40552 | 4.11 | 3/20/2024 |
| **4.12** | [Second Addendum, dated November 30, 2023, to Unprotected Lease Contract, by and between Nyxoah Ltd. and Block 7093 Parcel 162 Ltd. (English Translation)](https://www.sec.gov/Archives/edgar/data/1857190/000110465924036688/nyxh-20231231xex4d12.htm) | Form 20-F | 001-40552 | 4.12 | 3/20/2024 |
| **4.13#** | [Form of 2024 Warrants Plan (English Translation)](https://www.sec.gov/Archives/edgar/data/1857190/000110465924115918/tm2427399d1_ex99-1.htm) | Form S-8 | 333-283103 | 99.1 | 11/8/2024 |
| **4.14˄** | [Loan Facility Agreement, by and between Nyxoah SA and the European Investment Bank](https://www.sec.gov/Archives/edgar/data/1857190/000141057825000398/nyxh-20241231xex4d14.htm) | Form 20-F | 001-40552 | 4.14 | 3/20/2025 |
| **4.15˄** | [Form of Synthetic Warrant Agreement, by and between Nyxoah SA and the European Investment Bank](https://www.sec.gov/Archives/edgar/data/1857190/000141057825000398/nyxh-20241231xex4d15.htm) | Form 20-F | 001-40552 | 4.15 | 3/20/2025 |
| **4.16#** | [Form of 2025 Warrants Plan (English Translation)](https://www.sec.gov/Archives/edgar/data/1857190/000110465925026165/tm258421d1_ex99-1.htm) | Form S-8 | 333-285960 | 99.1 | 3/20/2025 |
| **4.17\*#** | [Form of 2025-2 Warrants Plan (English Translation)](nyxh-20251231xex4d17.htm) |  |  |  |  |
| **4.18\*** | [Form of Subscription Agreement, dated November 13, 2025, by and among Nyxoah SA and the investors party thereto](nyxh-20251231xex4d18.htm) |  |  |  |  |
| **4.19\*** | [Form of Securities Purchase Agreement, dated November 13, 2025, by and among Nyxoah SA and the investors party thereto](nyxh-20251231xex4d19.htm) |  |  |  |  |
| **4.20\***<sup>˄</sup> | [Notes Subscription Agreement, dated November 13, 2025, by and between Nyxoah SA and CVI Investments, Inc.](nyxh-20251231xex4d20.htm) |  |  |  |  |
| **4.21\***<sup>˄</sup> | [Amended and Restated Notes Subscription Agreement, dated December 16, 2025, by and between Nyxoah SA and CVI Investments, Inc.](nyxh-20251231xex4d21.htm)  |  |  |  |  |
| **4.22\***<sup>˄</sup> | [Bond Instrument, dated December 18, 2025, constituting the issue of €22,500,000 Amortising Senior Unsecured Convertible Bonds due 2028](nyxh-20251231xex4d22.htm) |  |  |  |  |
| **4.23\***<sup>˄</sup> | [First Supplemental Bond Instrument, dated February 2, 2026, constituting the issue of €22,500,000 Amortising Senior Unsecured Convertible Bonds due 2028](nyxh-20251231xex4d23.htm) |  |  |  |  |
| **4.24\***<sup>˄</sup> | [Consent and Amendment Letter, dated December 16, 2025, by and between Nyxoah SA and the European Investment Bank](nyxh-20251231xex4d24.htm) |  |  |  |  |
| **8.1** | [List of Subsidiaries of the registrant](https://www.sec.gov/Archives/edgar/data/1857190/000141057825000398/nyxh-20241231xex8d1.htm) | Form 20-F | &nbsp;&nbsp;001-40552 | &nbsp;&nbsp;8.1 | &nbsp;&nbsp;3/20/2025 |
| **11.1** | [Corporate Code of Conduct and Ethics and Whistleblower Policy](https://www.sec.gov/Archives/edgar/data/1857190/000141057825000398/nyxh-20241231xex11d1.htm) | Form 20-F | 001-40552 |  | 3/20/2025 |

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[**Table of Contents**](#TOC)

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| | | | | | |
|:---|:---|:---|:---|:---|:---|
| <br>**Exhibit**  | &nbsp;&nbsp;<br>**Description** | &nbsp;&nbsp;<br>**Schedule/Form** | &nbsp;&nbsp;<br>**FileNumber** | &nbsp;&nbsp;<br>**Exhibit** | &nbsp;&nbsp;<br>**FileDate** |
| **12.1\*** | [Rule 13a-14(a)/15d-14(a) Certification of Chief Executive Officer, as adopted pursuant to §302 of the Sarbanes-Oxley Act of 2002.](nyxh-20251231xex12d1.htm) |  |  |  |  |
| **12.2\*** | [Rule 13a-14(a)/15d-14(a) Certification of Chief Financial Officer, as adopted pursuant to §302 of the Sarbanes-Oxley Act of 2002.](nyxh-20251231xex12d2.htm) |  |  |  |  |
| **13.1\*\*** | [Section 1350 Certification of Chief Executive Officer, as adopted pursuant to §906 of the Sarbanes-Oxley Act of 2002](nyxh-20251231xex13d1.htm) |  |  |  |  |
| **13.2\*\*** | [Section 1350 Certification of Chief Financial Officer, as adopted pursuant to §906 of the Sarbanes-Oxley Act of 2002](nyxh-20251231xex13d2.htm) |  |  |  |  |
| **15.1\*** | [Consent of EY Réviseurs d'Entreprises / EY Bedrijfsrevisoren SRL/BV, independent registered public accounting firm](nyxh-20251231xex15d1.htm) |  |  |  |  |
| **97.1** | [Form of Clawback Policy of the Registrant](https://www.sec.gov/Archives/edgar/data/1857190/000110465924036688/nyxh-20231231xex97d1.htm) | Form 20-F | &nbsp;&nbsp;001-40552 | &nbsp;&nbsp;97.1 | &nbsp;&nbsp;3/20/2024 |
| **101. INS XBRL** | Instance Document |  |  |  |  |
| **101. SCH XBRL** | Taxonomy Extension Schema Document |  |  |  |  |
| **101. CAL XBRL** | Taxonomy Extension Calculation Linkbase Document |  |  |  |  |
| **101. DEF XBRL** | Taxonomy Extension Definition Linkbase Document |  |  |  |  |
| **101. LAB XBRL** | Taxonomy Extension Label Linkbase Document |  |  |  |  |
| **101. PRE XBRL** | Taxonomy Extension Presentation Linkbase Document |  |  |  |  |
| **104** | Cover Page Interactive Data File (embedded within the Inline XBRL document) |  |  |  |  |

---

\* Filed herewith.

\*\* Furnished herewith.

# Indicates management contract or compensatory plan.

+ Confidential treatment previously requested and granted as to portions of the exhibit. Confidential materials omitted and filed separately with the Securities and Exchange Commission.

<sup>˄</sup> Certain confidential portions of this exhibit were omitted by means of marking such portions with brackets ("[\*\*\*]") because the identified confidential portions (i) are not material and (ii) would be competitively harmful if publicly disclosed.

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#### Signature
The registrant hereby certifies that it meets all of the requirements for filing on Form 20-F and that it has duly caused and authorized the undersigned to sign this Annual Report on its behalf.

---

| | |
|:---|:---|
| **NYXOAH SA** | **NYXOAH SA** |
| **By:** | /s/ Olivier Taelman |
|  | Name: Olivier Taelman |
|  | Title:*&nbsp;&nbsp;&nbsp;&nbsp; Chief Executive Officer* |

---

Date: March 26, 2026

[**Table of Contents**](#TOC)

#### INDEX TO CONSOLIDATED FINANCIAL STATEMENTS

---

| | |
|:---|:---|
|  | **Page** |
| [Report of Independent Registered Accounting Firm](#REPORTOFAUDITOR_578029) (PCAOB ID: 01467) | F-2 |
| [Consolidated Balance Sheets for the years ended December 31, 2025 and 2024](#CONSOLIDATEDBALANCESHEETS_69072) | F-3 |
| [Consolidated Statements of Loss and Other Comprehensive Loss for the years ended December 31, 2025 and 2024](#CONSOLIDATEDSTATEMENTSOFLOSSANDOTHERCOMP) | F-4 |
| [Consolidated Statements of Changes in Equity for the years ended December 31, 2025, 2024 and 2023](#CONSOLIDATEDSTATEMENTSOFCHANGESINEQUITY_) | F-5 |
| [Consolidated Statements of Cash Flows for the years ended December 31, 2025, 2024 and 2023](#CONSOLIDATEDSTATEMENTSOFCASHFLOW_151867) | F-7 |
| [Notes to the Consolidated Financial Statements](#NOTESTOTHECONSOLIDATEDFINANCIALSTATEMENT) | F-8 |

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[**Table of Contents**](#TOC)

**REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM**

To the Shareholders and the Board of Directors of Nyxoah S.A.

**Opinion on the Financial Statements**

We have audited the accompanying consolidated balance sheets of Nyxoah SA (the Company) as of December 31, 2025 and 2024, the related consolidated statements of loss and other comprehensive loss, shareholders' equity and cash flows for each of the three years in the period ended December 31, 2025, and the related notes (collectively referred to as the "consolidated financial statements"). In our opinion, the consolidated financial statements present fairly, in all material respects, the financial position of the Company at December 31, 2025 and 2024, and the results of its operations and its cash flows for each of the three years in the period ended December 31, 2025, in conformity with International Financial Reporting Standards as issued by the International Accounting Standards Board.

**The Company's Ability to Continue as a Going Concern** 

The accompanying consolidated financial statements have been prepared assuming that the Company will continue as a going concern. As discussed in Note 5.1 to the financial statements, the Company has suffered recurring losses from operations, sustained negative cash flows since its inception and has stated that substantial doubt exists about the Company's ability to continue as a going concern. Management's evaluation of the events and conditions and management's plans regarding these matters are also described in Note 5.1. The consolidated financial statements do not include any adjustments that might result from the outcome of this uncertainty.

**Basis for Opinion**

These financial statements are the responsibility of the Company's management. Our responsibility is to express an opinion on the Company's financial statements based on our audits. We are a public accounting firm registered with the PCAOB and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement, whether due to error or fraud. The Company is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Company's internal control over financial reporting. Accordingly, we express no such opinion.

Our audits included performing procedures to assess the risks of material misstatement of the financial statements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements. We believe that our audits provide a reasonable basis for our opinion.

/s/ EY Réviseurs d'Entreprises / EY Bedrijfsrevisoren SRL/BV

We have served as the Company's auditor since 2016.

Diegem, Belgium

March 26, 2026

[**Table of Contents**](#TOC)

#### NYXOAH SA

#### CONSOLIDATED BALANCE SHEETS
**(in thousands)**

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
|  |  | **As at December 31** | **As at December 31** | **As at December 31** | **As at December 31** |
|  | **Notes** | **2025** | **2025** | **2024** | **2024** |
| **ASSETS** |  |  |  |  |  |
| **Non-current assets** |  |  |  |  |  |
| Property, plant and equipment | 7 |  | 4052 |  | 4753 |
| Intangible assets | 8 |  | 50108 |  | 50381 |
| Right of use assets | 9 |  | 1293 |  | 3496 |
| Deferred tax asset | 31 |  | 87 |  | 76 |
| Other long-term receivables | 10 |  | 1718 |  | 1617 |
|  |  | **€** | **57258** | **€** | **60323** |
| **Current assets** |  |  |  |  |  |
| Inventory | 11 |  | 4660 |  | 4716 |
| Trade receivables | 12 |  | 5254 |  | 3382 |
| Contract assets | 12 |  | 261 |  |  |
| Other receivables | 12 |  | 2209 |  | 2774 |
| Other current assets | 13 |  | 828 |  | 1656 |
| Financial assets | 15 |  | 18000 |  | 51369 |
| Cash and cash equivalents | 14 |  | 30001 |  | 34186 |
|  |  | **€** | **61213** | **€** | **98083** |
| &nbsp;&nbsp;**Total assets** |  | **€** | **118471** | **€** | **158406** |
| **EQUITY AND LIABILITIES** |  |  |  |  |  |
| **Share capital and reserves** |  |  |  |  |  |
| Share capital | 16 |  | 6505 |  | 6430 |
| Share premium | 16 |  | 335134 |  | 314345 |
| Share-based payment reserve | 17 |  | 12395 |  | 9300 |
| Other comprehensive income | 16 |  | 1124 |  | 914 |
| Retained loss |  |  | (306029) |  | (217735) |
| &nbsp;&nbsp;**Total equity attributable to shareholders** |  | **€** | **49129** | **€** | **113254** |
| **LIABILITIES** |  |  |  |  |  |
| **Non-current liabilities** |  |  |  |  |  |
| Financial debt | 18 |  | 17670 |  | 18725 |
| Lease liability | 9 |  | 637 |  | 2562 |
| Provisions | 19 |  | 1396 |  | 1000 |
| Deferred tax liability | 31 |  |  |  | 19 |
| Contract liability | 22 |  | 681 |  | 472 |
| Other liability | 21 |  |  |  | 845 |
|  |  | **€** | **20384** | **€** | **23623** |
| **Current liabilities** |  |  |  |  |  |
| Financial debt | 18 |  | 22990 |  | 248 |
| Lease liability | 9 |  | 779 |  | 1118 |
| Trade payables | 20 |  | 13727 |  | 9505 |
| Current tax liability | 31 |  | 3939 |  | 4317 |
| Contract liability | 22 |  | 894 |  | 117 |
| Other liability | 21 |  | 6629 |  | 6224 |
|  |  | **€** | **48958** | **€** | **21529** |
| &nbsp;&nbsp;**Total liabilities** |  | **€** | **69342** | **€** | **45152** |
| &nbsp;&nbsp;**Total equity and liabilities** |  | **€** | **118471** | **€** | **158406** |

---

*The accompanying notes are an integral part of these consolidated financial statements.*

[**Table of Contents**](#TOC)

#### NYXOAH SA

#### CONSOLIDATED STATEMENTS OF LOSS AND OTHER COMPREHENSIVE LOSS
**(in thousands)**

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
|  |  | **For the year ended December 31** | **For the year ended December 31** | **For the year ended December 31** | **For the year ended December 31** | **For the year ended December 31** | **For the year ended December 31** |
|  | **Notes** | **2025** | **2025** | **2024** | **2024** | **2023** | **2023** |
| Revenue | 22 | € | 10020 | € | 4521 | € | 4348 |
| Cost of goods sold | 22 |  | (3694) |  | (1552) |  | (1656) |
| **Gross profit** |  | **€** | **6326** | **€** | **2969** | **€** | **2692** |
| Research and Development Expense | 24 |  | (42824) |  | (34325) |  | (26651) |
| Selling, General and Administrative Expense | 25 |  | (48261) |  | (28461) |  | (21687) |
| Other income | 26 |  | 1274 |  | 1008 |  | 544 |
| **Operating loss for the period** |  |  | **(83485)** |  | **(58809)** |  | **(45102)** |
| Financial income | 29 |  | 5928 |  | 7447 |  | 4174 |
| Financial expense | 30 |  | (11519) |  | (5070) |  | (3729) |
| **Loss for the period before taxes** |  |  | **(89076)** |  | **(56432)** |  | **(44657)** |
| Income taxes | 31 |  | (1009) |  | (2804) |  | 1445 |
| **Loss for the period** |  |  | **(90085)** |  | **(59236)** |  | **(43212)** |
| **Loss attributable to equity holders** |  |  | **(90085)** |  | **(59236)** |  | **(43212)** |
| **Other comprehensive income** |  |  |  |  |  |  |  |
| **Items that may not be subsequently reclassified to profit or loss (net of tax)** |  |  |  |  |  |  |  |
| Remeasurements of post-employment benefit obligations, net of tax | 28 |  | (18) |  | 11 |  | 81 |
| **Items that may be subsequently reclassified to profit or loss (net of tax)** |  |  |  |  |  |  |  |
| Currency translation differences |  |  | 228 |  | 766 |  | (120) |
| **Total other comprehensive income** |  | **€** | **210** |  | **777** | **€** | **(39)** |
| **Total comprehensive loss for the year, net of tax** |  | **€** | **(89875)** | **€** | **(58459)** | **€** | **(43251)** |
| **Loss attributable to equity holders** |  | **€** | **(89875)** | **€** | **(58459)** | **€** | **(43251)** |
| Basic loss per share (in EUR) | 32 | € | (2.364) | € | (1.809) | € | (1.545) |
| Diluted loss per share (in EUR) | 32 | € | (2.364) | € | (1.809) | € | (1.545) |

---

*The accompanying notes are an integral part of these consolidated financial statements*

[**Table of Contents**](#TOC)

#### NYXOAH SA

#### CONSOLIDATED STATEMENTS OF CHANGES IN EQUITY
**(in thousands)**

---

| | | | | | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
|  |  | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** |
|  |  |  |  |  |  | **Share** | **Share** |  |  |  |  |  |  |
|  |  |  |  |  |  | **based** | **based** | **Other** | **Other** |  |  |  |  |
|  |  | **Common** | **Common** | **Share** | **Share** | **payment** | **payment** | **comprehensive** | **comprehensive** | **Retained** | **Retained** |  |  |
|  | **Notes** | **shares** | **shares** | **premium** | **premium** | **reserve** | **reserve** | **income** | **income** | **loss** | **loss** | **Total** | **Total** |
| **Balance at January 1, 2023** |  | **€** | **4440** | **€** | **228275** | **€** | **5645** | **€** | **176** | **€** | **(118212)** | **€** | **120324** |
| Loss for the period |  |  |  |  |  |  |  |  |  |  | (43212) |  | (43212) |
| Other comprehensive loss for the period |  |  |  |  |  |  |  |  | (39) |  |  |  | (39) |
| **Total comprehensive loss for the period** |  |  | **—** |  |  |  | **—** | **€** | **(39)** | **€** | **(43212)** | **€** | **(43251)** |
| Equity-settled share-based payments |  |  |  |  |  |  |  |  |  |  |  |  |  |
| &nbsp;&nbsp;Granted during the period |  |  |  |  |  |  | 2611 |  |  |  |  |  | 2611 |
| &nbsp;&nbsp;Exercised during the period |  |  | 2 |  | 60 |  | (18) |  |  |  | 18 |  | 62 |
| &nbsp;&nbsp;Expired during the period |  |  |  |  |  |  | (577) |  |  |  | 577 |  |  |
| Transaction cost |  |  |  |  | (340) |  |  |  |  |  |  |  | (340) |
| Issuance of shares for cash |  |  | 484 |  | 18132 |  |  |  |  |  |  |  | 18616 |
| **Total transactions with owners of the company recognized directly in equity** |  |  | **486** |  | **17852** |  | **2016** |  | **—** |  | **595** |  | **20949** |
| **Balance at December 31, 2023** |  | **€** | **4926** | **€** | **246127** | **€** | **7661** | **€** | **137** | **€** | **(160829)** | **€** | **98022** |

---

---

| | | | | | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
|  |  | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** |
|  |  |  |  |  |  | **Share-** | **Share-** |  |  |  |  |  |  |
|  |  |  |  |  |  | **based** | **based** | **Other** | **Other** |  |  |  |  |
|  |  | **Common** | **Common** | **Share** | **Share** | **payment** | **payment** | **comprehensive** | **comprehensive** | **Retained** | **Retained** |  |  |
|  | **Notes** | **shares** | **shares** | **premium** | **premium** | **reserve** | **reserve** | **income** | **income** | **loss** | **loss** | **Total** | **Total** |
| **Balance at January 1, 2024** |  | **€** | **4926** | **€** | **246127** | **€** | **7661** | **€** | **137** | **€** | **(160829)** | **€** | **98022** |
| Loss for the period |  |  |  |  |  |  |  |  |  |  | (59236) |  | (59236) |
| Other comprehensive income for the period |  |  |  |  |  |  |  |  | 777 |  |  |  | 777 |
| **Total comprehensive loss for the period** |  |  | **—** |  | **—** |  | **—** | **€** | **777** | **€** | **(59236)** | **€** | **(58459)** |
| Equity-settled share-based payments |  |  |  |  |  |  |  |  |  |  |  |  |  |
| &nbsp;&nbsp;Granted during the period | 17 |  |  |  |  |  | 3969 |  |  |  |  |  | 3969 |
| &nbsp;&nbsp;Expired during the period | 17 |  |  |  |  |  | (1848) |  |  |  | 1848 |  |  |
| &nbsp;&nbsp;Exercised during the period | 17 |  | 13 |  | 426 |  | (482) |  |  |  | 482 |  | 439 |
| Transaction cost | 16 |  |  |  | (3730) |  |  |  |  |  |  |  | (3730) |
| Issuance of shares for cash | 16 |  | 1491 |  | 71522 |  |  |  |  |  |  |  | 73013 |
| **Total transactions with owners of the company recognized directly in equity** |  |  | **1504** |  | **68218** |  | **1639** |  | **—** |  | **2330** |  | **73691** |
| **Balance at December 31, 2024** |  | **€** | **6430** | **€** | **314345** | **€** | **9300** | **€** | **914** | **€** | **(217735)** | **€** | **113254** |

---

[**Table of Contents**](#TOC)

---

| | | | | | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
|  |  | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** | **Attributable to owners of the parent** |
|  |  |  |  |  |  | **Share-** | **Share-** |  |  |  |  |  |  |
|  |  |  |  |  |  | **based** | **based** | **Other** | **Other** |  |  |  |  |
|  |  | **Common** | **Common** | **Share** | **Share** | **payment** | **payment** | **comprehensive** | **comprehensive** | **Retained** | **Retained** |  |  |
|  | **Notes** | **shares** | **shares** | **premium** | **premium** | **reserve** | **reserve** | **income** | **income** | **loss** | **loss** | **Total** | **Total** |
| **Balance at January 1, 2025** |  | **€** | **6430** | **€** | **314345** | **€** | **9300** | **€** | **914** | **€** | **(217735)** | **€** | **113254** |
| Loss for the period |  |  |  |  |  |  |  |  |  |  | (90085) |  | (90085) |
| Other comprehensive income for the period |  |  |  |  |  |  |  |  | 210 |  |  |  | 210 |
| **Total comprehensive loss for the period** |  |  | **—** |  | **—** |  | **—** | **€** | **210** | **€** | **(90085)** | **€** | **(89875)** |
| Equity-settled share-based payments |  |  |  |  |  |  |  |  |  |  |  |  |  |
| &nbsp;&nbsp;Granted during the period | 17 |  |  |  |  |  | 4886 |  |  |  |  |  | 4886 |
| &nbsp;&nbsp;Expired during the period | 17 |  |  |  |  |  | (906) |  |  |  | 906 |  |  |
| &nbsp;&nbsp;Exercised during the period | 17 |  | 20 |  | 72 |  | (885) |  |  |  | 885 |  | 92 |
| Transaction cost | 16 |  |  |  | (1155) |  |  |  |  |  |  |  | (1155) |
| Issuance of shares for cash | 16 |  | 55 |  | 21872 |  |  |  |  |  |  |  | 21927 |
| **Total transactions with owners of the company recognized directly in equity** |  |  | **75** |  | **20789** |  | **3095** |  | **—** |  | **1791** |  | **25750** |
| **Balance at December 31, 2025** |  | **€** | **6505** | **€** | **335134** | **€** | **12395** | **€** | **1124** | **€** | **(306029)** | **€** | **49129** |

---

*The accompanying notes are an integral part of these consolidated financial statements.*

[**Table of Contents**](#TOC)

#### NYXOAH SA

#### CONSOLIDATED STATEMENTS OF CASH FLOW
**(in thousands)**

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
|  |  | **For the year ended December 31** | **For the year ended December 31** | **For the year ended December 31** | **For the year ended December 31** | **For the year ended December 31** | **For the year ended December 31** |
|  | **Notes** | **2025** | **2025** | **2024** | **2024** | **2023** | **2023** |
| **CASH FLOWS FROM OPERATING ACTIVITIES** |  |  |  |  |  |  |  |
| **Loss before tax for the year** |  | **€** | **(89076)** | **€** | **(56432)** | **€** | **(44657)** |
| Adjustments for |  |  |  |  |  |  |  |
| &nbsp;&nbsp;Finance income | 29 |  | (5928) |  | (7447) |  | (4174) |
| &nbsp;&nbsp;Finance expenses | 30 |  | 11519 |  | 5070 |  | 3729 |
| &nbsp;&nbsp;Depreciation of property, plant and equipment and right-of-use assets | 79 |  | 2254 |  | 1752 |  | 1398 |
| &nbsp;&nbsp;Amortization of intangible assets | 8 |  | 2230 |  | 966 |  | 962 |
| &nbsp;&nbsp;Impairment loss on tangible and intangible assets | 78 |  | 1177 |  |  |  |  |
| &nbsp;&nbsp;Impairment loss on trade receivables | 12 |  | 503 |  |  |  |  |
| &nbsp;&nbsp;Net loss on disposal of property, plant and equipment and right-of-use assets | 79 |  | 162 |  |  |  |  |
| &nbsp;&nbsp;Lease modification | 9 |  | (119) |  |  |  |  |
| &nbsp;&nbsp;Share-based payment transaction expense | 17 |  | 4886 |  | 3968 |  | 2611 |
| &nbsp;&nbsp;Remeasurement of recoverable cash advances | 18 |  | (1142) |  | (561) |  | (324) |
| &nbsp;&nbsp;Increase in provisions |  |  | 377 |  | 817 |  | 216 |
| &nbsp;&nbsp;Other non-cash items |  |  | (150) |  | 214 |  | (256) |
| **Cash used before changes in working capital** |  | **€** | **(73307)** | **€** | **(51653)** | **€** | **(40495)** |
| &nbsp;&nbsp;(Decrease)/Increase in inventory |  |  | 56 |  | (1401) |  | (2433) |
| &nbsp;&nbsp;Increase in trade and other receivables, contract assets and other current assets |  |  | (2140) |  | (751) |  | (1540) |
| &nbsp;&nbsp;Increase in trade payables, contract and other liabilities |  |  | 7455 |  | 5114 |  | 479 |
| &nbsp;&nbsp;**Cash used from changes in operations** |  | **€** | **(67936)** | **€** | **(48691)** |  | **(43989)** |
| &nbsp;&nbsp;Income tax paid |  |  | (1043) |  | (535) |  | (789) |
| &nbsp;&nbsp;**Net cash used in operating activities** |  | **€** | **(68979)** | **€** | **(49226)** |  | **(44778)** |
| &nbsp;&nbsp;**CASH FLOWS FROM INVESTING ACTIVITIES** |  |  |  |  |  |  |  |
| &nbsp;&nbsp;Purchases of property, plant and equipment | 7 |  | (805) |  | (1165) |  | (2500) |
| &nbsp;&nbsp;Capitalization of intangible assets | 8 |  | (2964) |  | (4907) |  | (8462) |
| &nbsp;&nbsp;Disposal of tangible assets |  |  | 3 |  | 7 |  |  |
| &nbsp;&nbsp;Purchase of financial assets - current | 15 |  | (42050) |  | (97831) |  | (80018) |
| &nbsp;&nbsp;Proceeds from sale of financial assets - current | 15 |  | 71996 |  | 85312 |  | 120681 |
| &nbsp;&nbsp;Interest income on financial assets |  |  | 2152 |  | 2259 |  | 2310 |
| **Net cash generated from / (used in) investing activities** |  | **€** | **28332** | **€** | **(16325)** | **€** | **32011** |
| **CASH FLOWS FROM FINANCING ACTIVITIES** |  |  |  |  |  |  |  |
| &nbsp;&nbsp;Payment of principal portion of lease liabilities | 9 |  | (1133) |  | (1208) |  | (757) |
| &nbsp;&nbsp;Repayment of other loan |  |  |  |  | (63) |  | (83) |
| &nbsp;&nbsp;Interests paid | 30 |  | (694) |  | (496) |  | (192) |
| &nbsp;&nbsp;Repayment of recoverable cash advance | 18 |  | (179) |  | (254) |  | (396) |
| &nbsp;&nbsp;Proceeds from other loans |  |  |  |  | 10000 |  |  |
| &nbsp;&nbsp;Proceeds from convertible bond | 18 |  | 22500 |  |  |  |  |
| &nbsp;&nbsp;Proceeds from issuance of shares, net of transaction costs | 16 |  | 20864 |  | 69722 |  | 18337 |
| &nbsp;&nbsp;Transaction costs related to convertible bond | 25 |  | (3149) |  |  |  |  |
| &nbsp;&nbsp;Other financial costs |  |  | (102) |  | (262) |  | (51) |
| **Net cash generated from financing activities** |  | **€** | **38107** | **€** | **77439** |  | **16858** |
| **Movement in cash and cash equivalents** |  | **€** | **(2540)** | **€** | **11888** | **€** | **4091** |
| &nbsp;&nbsp;Effect of exchange rates on cash and cash equivalents |  |  | (1645) |  | 688 |  | (369) |
| **Cash and cash equivalents at January 1** | **14** | **€** | **34186** | **€** | **21610** | **€** | **17888** |
| **Cash and cash equivalents at December 31** | **14** | **€** | **30001** | **€** | **34186** |  | **21610** |

---

*The accompanying notes are an integral part of these consolidated financial statements.*

[**Table of Contents**](#TOC)

#### NYXOAH SA

#### NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
**1.**General information

Nyxoah SA (the "Company") is a public listed company with limited liability (naamloze vennootschap/société anonyme) incorporated and operating under the laws of Belgium and is domiciled in Belgium. Nyxoah SA is registered with the legal entities register (Brabant Walloon) under enterprise number 0817.149.675. The Company's registered office is in Rue Edouard Belin 12, 1435 Mont-Saint-Guibert, Belgium.

The Company is a medical technology company focused on the development and commercialization of innovative solutions to treat Obstructive Sleep Apnea, or OSA. Our lead solution is the Genio system, a CE-Marked, patient-centric, minimally invasive, next generation hypoglossal neurostimulations therapy for OSA. OSA is the world's most common sleep disordered breathing condition and is associated with increased mortality risk and comorbidities including cardiovascular diseases, depression and stroke.

The Genio system is the first neurostimulation system for the treatment of OSA to include a battery-free and leadless neurostimulator capable of delivering bilateral hypoglossal nerve stimulation to keep the upper airway open. The product is intended to be used as a second-line therapy to treat moderate to severe OSA patients who have either not tolerated, failed or refused conventional therapy, including Continuous Positive Airway Pressure, or CPAP, which, despite its proven efficacy, is associated with many limitations, meaning compliance is a serious challenge. In addition, other second-line treatments are more suitable to treat mild to moderate OSA (such as oral devices) or highly invasive. Compared to other hypoglossal nerve stimulation technologies for the treatment of OSA, the Genio system is a disruptive, differentiating technology that targets a clear unmet medical need thanks to its minimally invasive and quick implantation technique, its external battery and its ability to stimulate the two branches of the hypoglossal nerve.

Obstructive sleep apnea is the world's most common sleep disordered breathing condition. OSA occurs when the throat and tongue muscles and soft tissues relax and collapse. It makes a person stop breathing during sleep, while the airway repeatedly becomes partially (hypopnea) or completely (apnea) blocked, limiting the amount of air that reaches the lungs. During an episode of apnea or hypopnea, the patient's oxygen level drops, which leads to sleep interruptions.

Nyxoah SA has four wholly owned subsidiaries: Nyxoah Ltd, a subsidiary of the Company since October 21, 2009 (located in Israel and incorporated on January 10, 2008 under the name M.L.G. Madaf G. Ltd), Nyxoah Pty Ltd since February 1, 2017 (located in Australia), Nyxoah Inc. since May 14, 2020 (located in the USA) and Nyxoah GmbH since July 26, 2023 (located in Germany).

These consolidated financial statements have been authorized for issue on March 26, 2026 by the Board of Directors of the Company.

**2.** **Material accounting policies**

**2.1.** **Basis of preparation and going concern**

#### Basis of preparation
The Company's consolidated financial statements have been prepared in accordance with International Financial Reporting Standards ("IFRS"), as issued by the International Accounting Standards Board (IASB) and as endorsed by the European Union.

The consolidated financial statements have been prepared on a historical cost basis, except for derivative financial instruments that have been measured at fair value. The consolidated financial statements are presented in thousands of Euros (€) and all values are rounded to the nearest thousand, except when otherwise indicated (e.g. € million).

The preparation of the consolidated financial statements requires the use of certain critical accounting estimates. It also requires management to exercise its judgment in the process of applying the Company's accounting policies. The areas involving a higher degree of judgement or complexity, are areas where assumptions and estimates are significant to the consolidated financial statements.

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#### Going concern principle
The consolidated financial statements have been prepared on a going concern basis. Please refer to note 5.1 for the detailed explanation of the going concern.

***The Company continues to monitor potential impacts from the U.S. political environment ('Liberation Day Trump'). For the period ended as at December 31, 2025, the estimated effects have been reflected, with no material impact on operations or financial results for the period.***

**2.2.** **New and amended standards and interpretations applicable**

*Effective for the annual periods beginning on January 1, 2025*

The Group has not early adopted any standard, interpretation or amendment that has been issued but is not yet effective.

Several amendments and interpretations apply for the first time in 2025, but do not have an impact on the consolidated financial statements of the Company:

- Amendments to IAS 21 The Effect of Changes in Foreign Exchange Rates: Lack of Exchangeability

The following amendment is not an integral part of standards and, therefore, do not have an effective date. It will also not be endorsed for use in the European Union.

- Disclosures about Uncertainties in the Financial Statements (Illustrative Examples)

*Standards and interpretations published, but not yet applicable for the annual period beginning on 1 January 2025*

- IFRS 18 Presentation and Disclosure in Financial Statements (applicable for annual periods beginning on or after 1 January 2027)

- Amendments to IFRS 9 and IFRS 7 Classification and Measurement of Financial Instruments (applicable for annual periods beginning on or after 1 January 2026)

- Annual Improvements – Volume 11 (applicable for annual periods beginning on or after 1 January 2026)

None of the IFRS standards issued, but not yet effective are expected to have a material impact on the Company's financial statements, except for IFRS 18 the new standard on presentation and disclosure in financial statements, with a focus on updates to the statement of profit or loss.

IFRS 18 will replace IAS 1; many of the existing principles in IAS 1 are retained, with limited changes. IFRS 18 will not impact the recognition or measurement of items in the financial statements, but it will change the presentation within the income statement. Additional requirements for management performance measures and aggregation or disaggregation could impact the disclosures as presented in the financial statements.

IFRS 18 will apply for reporting periods beginning on or after 1 January 2027 and also applies to comparative information. The Group currently does not foresee early adoption.

The changes in presentation and disclosure required by IFRS 18 might require system and process changes and the Group is currently assessing this impact.

**2.3.** **Basis of consolidation**

The consolidated financial statements comprise the financial statements of the Company and its subsidiaries as at December 31, 2025, 2024 and 2023.

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Subsidiaries are all entities (including structured entities) over which the Company has control. The Company controls an entity when the Company is exposed to, or has rights to, variable returns from its involvement with the entity and has the ability to affect those returns through its power over the entity. Subsidiaries are fully consolidated from the date on which control is transferred to the Company. They are deconsolidated from the date control ceases.

Inter-company transactions, balances and unrealized gains on transactions between group companies are eliminated.

**2.4.** **Foreign currency translations**

The consolidated financial statements are presented in Euro, which is the Company's functional and presentation currency. For each subsidiary, the Company determines the functional currency. Items included in the financial statements of each subsidiary are measured using that functional currency.

Transactions in foreign currencies are recorded at their respective foreign exchange rate prevailing at the date of the transaction. Monetary assets and liabilities denominated in foreign currencies are translated at the foreign exchange rates prevailing at the closing date. Exchange differences arising on the settlement of monetary items or on reporting monetary items at rates different from those at which they were initially recorded during the period or in previous periods, are recognized in the consolidated income statement in the line item "financial expense" or "financial income". Non-monetary items that are measured in terms of historical cost in a foreign currency are translated using the exchange rates as at the date of the initial transactions.

On consolidation, the assets and liabilities of foreign operations are translated into euros at the rate of exchange prevailing at the reporting date and the income statement per quarter is translated at the average rate of the respective quarter. The exchange differences arising on the translation are recognized in other comprehensive income. On disposal of a foreign operation, the component of other comprehensive income relating to that particular foreign operation is recognized in the income statement.

**2.5.** **Intangible assets**

***Patents***

Patents relate to direct attributable expenditure incurred for obtaining patent rights related to the Genio system and are carried at costs less accumulated amortization and accumulated impairment losses. Patents costs are amortized as from January 2021 together with the related Genio system capitalized development costs.

***Research and development costs***

Research costs are expensed as incurred. Development expenditures on an individual project are recognized as an intangible asset when the Company can demonstrate:

&nbsp;&nbsp;&nbsp;&nbsp;● the technical feasibility of completing the intangible asset so that it will be available for use or sale;

&nbsp;&nbsp;&nbsp;&nbsp;● the intention to complete the intangible asset and use or sell it;

&nbsp;&nbsp;&nbsp;&nbsp;● the ability to use or sell the intangible asset;

&nbsp;&nbsp;&nbsp;&nbsp;● how the intangible asset will generate probable future economic benefits;

&nbsp;&nbsp;&nbsp;&nbsp;● the availability of adequate technical, financial and other resources to complete the development and to use or sell the intangible asset; and

&nbsp;&nbsp;&nbsp;&nbsp;● the ability to measure reliably the expenditure attributable to the intangible asset during its development.

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The Company started recognizing the development expenditure as an asset since March 2019 triggered by obtaining CE mark for the first generation of the Genio system. As from July 2020, the Company started recognizing the development expenditure as an asset for the improved second generation of the Genio system. The asset is carried at cost less any accumulated amortization and accumulated impairment losses. Development costs include employee compensation and outsourced development expenses. Amortization of the asset begins when development is complete and the asset is available for use. The asset is depreciated on a straight-line basis over the estimated useful life (until December 2034). During the period of development, the asset is tested for impairment annually. Amortization for the first generation of the Genio system started in 2021. Following the FDA approval for the Genio system on August 8, 2025, the amortization of the related intangible assets commenced in Q3 2025. The amortization expense is recognized in research and development expense. See note 8

**2.6.** **Property, plant and equipment**

Property, plant and equipment are initially recorded in the statement of financial position at their acquisition cost, which includes the costs directly attributable to the acquisition and installation of the asset.

Property, plant and equipment are subsequently measured at their historical cost less accumulated depreciation and impairment, if any.

Property, plant and equipment are depreciated on a straight-line basis over their estimated useful life. The estimated useful life of each category of property, plant and equipment is as follows:

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| | |
|:---|:---|
| ● IT equipment<br>| 3 years |
| ● Furniture and office equipment<br>| 5 to 15 years |
| ● Laboratory equipment<br>| 15 years |
| ● Leasehold improvements<br>| The shorter of lease term and 10 years |

---

Assets under construction are not depreciated until the date that the asset is available for use.

Property, plant and equipment are derecognized upon disposal or when no future economic benefits are expected from its use or disposal. Any gain or loss arising on derecognition of the asset, which is the difference between the net disposal proceeds and the carrying amount of the asset, is included in the income statement when the asset is derecognized.

The residual values, useful lives and methods of depreciation of property, plant and equipment are reviewed at each financial year end and adjusted prospectively, if appropriate.

**2.7.** **Impairment of intangible assets and property, plant and equipment**

At each reporting date, the Company assesses whether there is an indication that property, plant and equipment and intangible assets with a definite useful life may be impaired. If an indication of impairment exists, or at least annually when impairment test is required in case of intangible assets with an indefinite useful life or intangible assets not yet ready for use, the Company estimates the asset's recoverable amount. The recoverable amount of an asset is the higher of the assets or cash-generating units (CGU) fair value less costs to sell and its value in use.

The recoverable amount is determined based on the value in use of the individual asset or the CGU. In assessing value in use, the estimated future pre-tax cash flows are discounted to their present value using a pre-tax discount rate that reflects current market assessments of the time value of money and the risks specific to the asset.

A previously recognized impairment loss is reversed only if there has been a change in the assumptions used to determine the asset's recoverable amount since the last impairment loss was recognized. The reversal is limited so that the carrying amount of the asset does not exceed its recoverable amount, nor exceeds the carrying amount that would have been determined, net of depreciation, had no impairment loss has been recognized for the asset in prior years. Such reversal is recognized in the consolidated income statement.

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**2.8.** **Financial assets**

Financial assets mainly include trade receivables, other receivables (which gives a contractual right to receive cash or another financial asset from another entity), term accounts with an initial maturity longer than 3 months but less than 12 months and cash and cash equivalents, and are measured at amortized cost using the effective interest method, less impairment allowance. Interest income is recognized by applying the effective interest rate, except for short-term receivables when the effect of discounting is immaterial.

***Derecognition***

A financial asset is derecognized when the contractual rights to receive cash flows from the asset have expired or when the Company transferred its rights to receive cash flows and substantially all risks and rewards of ownership of the financial asset to another party.

***Expected credit loss***

The Company applies the simplified approach under IFRS 9 in measuring expected credit losses on contract assets. Under this approach, a lifetime expected credit loss allowance is recognized for all contract assets.

Expected credit losses are measured using a provision matrix based on the ageing of contract assets. The provision rates are determined based on historical collection experience, adjusted for forward-looking information where relevant, and specific customer-related facts and circumstances. Older balances are subject to higher provision rates, and contract assets are fully provided for when there is no reasonable expectation of recovery.

The expected credit loss allowance is reassessed at each reporting date and updated as necessary to reflect changes in collection patterns, known credit risks and available forward-looking information.

**2.9.** **Financial liabilities**

The financial liabilities include financial debt, derivative liabilities, trade payables and other payables.

***Liabilities at amortized cost***

Those financial liabilities, except for the derivative liabilities, are measured at amortized cost using the effective interest rate method. Amortized cost is calculated by taking into account any discount or premium on acquisition and fees or costs that are an integral part of the effective interest rate. The effective interest rate amortization is included as financial cost in the consolidated income statement. When the estimated contractual cash flows are changed, the entity recalculates the gross carrying amount of the financial liability as the present value of the changed cash flows discounted at the original effective interest rate. The difference between the recalculated carrying amount and the initial carrying amount is included in other operating income & expense in the consolidated income statement.

***Liabilities at fair value with changes in fair value through profit and loss***

The Company has derivative liabilities consisting of foreign currency options to hedge its contingency risk exposure to certain foreign currencies, non-closely related embedded derivatives related to a finance agreement with the European Investment Bank ("EIB") and a convertible bond instruments.

Those derivative financial instruments are initially recorded at fair value and derivative financial instruments are subsequently remeasured at their fair value with changes in fair value recorded in the income statement under "Financial income/financial expenses". Any transactions costs incurred are immediately recognized in the consolidated income statement.

The fair value of a hedging derivative financial instrument (foreign currency options) is classified as a non-current liability when the remaining maturity of the hedged item is more than 12 months and as a current liability when the remaining maturity of the hedged item is less than 12 months. The fair value is recorded in the consolidated balance sheet under "Other payables". The Company does not apply hedge accounting to those derivative financial liabilities.

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The Company has entered in a finance agreement with the European Investment Bank ("EIB"). This agreement is a hybrid financial instrument consisting out of a host financial loan and 3 embedded derivatives (i.e. prepayment option, partial settlement option and synthetic warrants). The prepayment option derivative held by the Company, the Synthetic Warrants issued in favor of EIB as well as the partial settlement option to settled in Warrants instead of in cash are considered to be embedded derivatives not closely related to the host financial instrument and are accounted for separately from the host contract. The Synthetic Warrants as well as the partial settlement option derivatives are however considered to be closely related to each other and are considered as one embedded derivative to be valued hereafter named Synthetic Warrants jointly. The prepayment option is accounted for at fair value through profit and loss. The fair value is determined by management using valuation techniques which are dependent on inputs such as credit ratings, probability of (a change in) the credit rating and discount rates. Synthetic Warrants are valued on basis of a binomial tree model and accounted for at fair value through profit and loss. The fair value of the Synthetic Warrants, which are not traded in an active market, is determined by management using valuation techniques which are dependent on inputs such as share prices, share volume, discount rates and foreign currency exchange rates. The effective interest rate method applied to the host financial loan considers the transaction cost of the loan as well as the initial fair value of the non-closely related embedded derivatives that are separated from the host financial instrument.

The Company entered into a bond subscription agreement with an international financial services firm for the issuance of convertible bonds for an aggregate maximum principal amount of up to €45 million ("Bond Instrument"). The financing consists of a first tranche of €22.5 million with an option to issue a second tranche of €22.5 million at the Company's discretion, within the period commencing 7 months following the first tranche closing date to (but excluding) the date falling one month thereafter. The Bond Instrument contains a host financial liability with embedded derivatives that are closely related and embedded derivatives (full and partial conversion rights for the holder and the issuer and certain prepayment payment features) that are not closely related. Management has designated the entire Bond Instrument at fair value through profit and loss. The fair value of the Bond Instrument is determined by management using valuation techniques which are dependent on inputs such as share prices, expected volatility and discount rates. The transaction price of the Bond Instrument at initial recognition is the consideration of the first tranche for €22.5 million. Taking into account the Bond Instrument is a Level 3 fair value, the difference between the transaction price and the fair value at initial recognition is considered a 'day 1' result which is recognized in profit and loss on a systematic straight line basis throughout the term of the Bond Instrument. Transaction costs are recognized in financial expenses in the consolidated income statement. At each closing date, the Bond Instrument will be remeasurement at fair value with changes in fair value recognized in the income statement. In case (part of) the bond will be settled in the Company's own equity instruments, a part of the financial liability is considered settled ("Conversion Settlement"). At each Conversion Settlement, the Bond Instrument will be remeasurement at fair value with changes in fair value recognized in the income statement, and subsequently the fair value of the consideration will be reclassified from the Bond Instrument carrying amount to Share Capital and Reserves.

**2.10. Inventory**

Inventories consist of raw materials, work-in-progress and finished goods of the Genio System and related components. Inventories are valued at the lower of cost and net realizable value. Costs incurred in bringing each product to its present location and condition are accounted for as follows:

&nbsp;&nbsp;&nbsp;&nbsp;● Raw materials: purchase cost based on FIFO ("first-in-first-out") method

&nbsp;&nbsp;&nbsp;&nbsp;● Work in progress and finished goods: measured using standard costs, which approximate actual manufacturing costs. Standard costs are reviewed periodically and material variances between standard cost and actual costs are recognized in profit or loss.

Net realizable value is the estimated selling price in the ordinary course of business, less estimated costs of completion and the estimated costs necessary to make the sale.

**2.11. Cash and cash equivalents**

Cash and cash equivalents include cash in hand, deposits held at call with banks, other short-term deposits with a maturity of or less than 3 months, and which are subject to an insignificant risk of changes in value.

**2.12. Income taxes**

Income taxes include current income tax and deferred income tax.

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***Current income tax***

Current income tax assets and liabilities are measured at the amount expected to be recovered from or paid to the tax authorities. Tax rates and tax laws that are considered to determine the amount of tax assets or liabilities are those that are enacted or substantially enacted, at the reporting date.

The current income tax liability includes a liability for tax positions subject to uncertainty over income tax treatment when it is probable that an outflow of economic resources will occur. Measurement of the liability for tax positions subject to uncertainty over income tax treatment is based on either the most likely amount method or the expected value method based on the Company's best estimate of the underlying risk.

***Deferred income tax***

A deferred tax effect is booked on temporary differences between the tax bases of assets and liabilities and their carrying amounts for financial reporting purposes at reporting date.

A deferred tax liability shall be recognised for all taxable temporary differences, except to the extent that the deferred tax liability arises from the initial recognition of goodwill or the initial recognition of an asset or liability in a transaction which (i) is not a business combination; (ii) at the time of the transaction, affects neither accounting profit nor taxable profit (tax loss); and (iii) at the time of the transaction, does not give rise to equal taxable and deductible temporary differences.

A deferred tax asset shall be recognised for all deductible temporary differences to the extent that it is probable that taxable profit will be available against which the deductible temporary difference can be utilised, unless the deferred tax asset arises from the initial recognition of an asset or liability in a transaction that is not a business combination; at the time of the transaction, affects neither accounting profit nor taxable profit (tax loss); and at the time of the transaction, does not give rise to equal taxable and deductible temporary differences. A deferred tax asset shall be recognised for the carryforward of unused tax losses and unused tax credits to the extent that it is probable that future taxable profit will be available against which the unused tax losses and unused tax credits can be utilised.

The carrying amount of deferred tax assets is reviewed at each reporting date and reduced to the extent that it is no longer probable that sufficient taxable profit will be available to allow all or part of the deferred tax asset to be utilized. Unrecognized deferred tax assets are re-assessed at each reporting date and are recognized to the extent that it has become probable that future taxable profits will allow the deferred tax asset to be recovered.

Deferred tax assets and tax liabilities are measured at the tax rates that are expected to apply in the year when the asset is realized or the liability is settled, based on tax rates (and tax laws) that have been enacted or substantially enacted at the reporting date.

Deferred tax assets and deferred tax liabilities are offset if a legally enforceable right exists to set off current tax assets against current tax liabilities and the deferred taxes relate to the same taxation authority.

**2.13. Employee benefits**

***Short-term employee benefits***

Short-term employee benefits include salaries and social security taxes, paid vacation and bonuses. They are recognized as expenses for the period in which employees perform the corresponding services. Outstanding payments at the end of the period are presented within current liabilities (other payables).

***Post-employment benefits***

Post-employment benefits include pensions and retirement benefits for employees, which are covered by contributions of the Company.

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The Company has set up a pension plan for its employees which qualifies as Defined Benefit pension plan under IAS 19. In the view of the minimum legal returns guaranteed under such scheme, those plans qualify as Defined Benefits plans. Such pension scheme is treated in accordance with IAS 19 "Employee Benefits" as a defined benefit plan. For defined benefit plans, the amount recognized in the Statement of financial position as a net liability (asset) corresponds to the difference between the present value of future obligations and the fair value of the plan assets.

The present value of the obligation and the costs of services are determined by using the "projected unit credit method" and actuarial valuations are performed at the end of each reporting period. The actuarial calculation method implies the use of actuarial assumptions by the Company, involving the discount rate, evolution of wages, employee turnover and mortality tables. These actuarial assumptions correspond to the best estimations of the variables that will determine the final cost of post-employment benefits. The discount rate reflects the rate of return on high quality corporate bonds with a term equal to the estimated duration of the post-employment benefits obligations. The actuarial calculations of post-employment obligations are performed by independent actuaries.

Remeasurement, comprising actuarial gains and losses, the effect of the changes to the asset ceiling (if applicable) and the return on plan assets (excluding interest), is reflected immediately in the consolidated statement of financial position with a charge or credit recognized in other comprehensive income in the period in which they occur. Remeasurement recognized in other comprehensive income is reflected immediately in retained loss and will not be reclassified to profit or loss.

**2.14. Share-based compensation**

***Equity-settled share-based compensation***

The Company operates an equity-based compensation plan, whereby warrants are granted to directors, management and selected employees and non-employees. The warrants are accounted for as equity-settled share-based payment plans since the Company has no legal or constructive obligation to repurchase or settle the warrants in cash.

Each warrant gives the beneficiaries the right to subscribe to one or several common share of the Company. The warrants are granted for free and have an exercise price which is determined by the Board of Directors of the Company.

The fair value of the employee services received in exchange for the grant of stock options or warrants is determined at the grant date using a Black & Scholes valuation model.

The costs of equity-settled transactions are recognized in employee benefit expense. The total amount to be expensed over the vesting period, if any, with a corresponding increase in the « share-based payment reserve » within equity, is determined by reference to the fair value of the stock options or warrants granted, excluding the impact of any non-market vesting conditions. The cumulative expense recognized for equity-settled transactions at each reporting date until the vesting date reflects the extent to which the vesting period has expired and the entity's best estimate of the number of equity instruments that will ultimately vest. At each closing date, the entity revises its estimates of the number of stock options that are expected to become exercisable. The impact of the revision of the original estimates, if any, is recognized in profit or loss such that the cumulative expense reflects the revised estimate, with a corresponding adjustment to reserves.

The proceeds received net of any directly attributable transaction costs are credited to share capital when the stock options or the warrants are exercised. When warrants granted under a share-based compensation plan are exercised or when they are not exercised and have expired, the amount previously recognized under the share-based payment reserve is reclassified to the caption retained loss, within equity.

**2.15. Leases**

The Company assesses at contract inception whether a contract is, or contains, a lease. That is, if the contract conveys the right to control the use of an identified asset for a period of time in exchange for consideration.

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***Right-of-use assets***

The Company recognizes right-of-use assets at the commencement date of the lease (i.e., the date the underlying asset is available for use). Right-of-use assets are measured at cost, less any accumulated depreciation and impairment losses, and adjusted for any remeasurement of lease liabilities. The cost of right-of-use assets includes the amount of lease liabilities recognized, initial direct costs incurred, and lease payments made at or before the commencement date less any lease incentives received. Unless the Company is reasonably certain to obtain ownership of the leased asset at the end of the lease term, the recognized right-of-use assets are depreciated on a straight-line basis over the shorter of its estimated life and the lease term. Right-of-use assets are subject to impairment, but no impairment has been identified in fiscal year 2023, 2024 and 2025.

***Lease liabilities***

At the commencement date of the lease, the Company recognizes lease liabilities measured at the present value of lease payments to be made over the lease term. The lease payments include fixed payments (including in-substance fixed payments) less any lease incentives receivable, variable lease payments that depend on an index or a rate, and amounts expected to be paid under residual value guarantees. The lease payments also include the exercise price of a purchase option reasonably certain to be exercised by the Company and payments of penalties for terminating a lease, if the lease term reflects the Company exercising the option to terminate. The variable lease payments that do not depend on an index or a rate are recognized as expense in the period in which the event or condition that triggers the payment occurs.

In calculating the present value of lease payments, the Company uses the incremental borrowing rate at the lease commencement date if the interest rate implicit in the lease is not readily determinable. After the commencement date, the amount of lease liabilities is increased to reflect the accretion of interest and reduced for the lease payments made. In addition, the carrying amount of lease liabilities is remeasured if there is a modification, a change in the lease term, a change in the in-substance fixed lease payments or a change in the assessment to purchase the underlying asset.

***Short-term leases and leases of low-value assets***

The Company applies the short-term lease recognition exemption to its short-term leases of machinery, equipment and buildings (i.e., those leases that have a lease term of 12 months or less from the commencement date and do not contain a purchase option). It also applies the lease of low-value assets recognition exemption to leases of office equipment and bicycles that are considered of low value (i.e., below €5,000). Lease payments on short-term leases and leases of low-value assets are recognized as expense on a straight-line basis over the lease term. See note **33.2**.

**2.16. Revenue**

The Company generates revenue from the sale of its Genio system, which is commercialized outside the U.S. and in the U.S. through direct sales to hospitals and via distributors in regions where the Company does not have a direct commercial presence. Revenue is recognized based on the satisfaction of performance obligations identified in customer contracts.

***Identification of performance obligations and revenue recognition***

Performance obligations are satisfied when control of the Genio system is transferred to the customer, either upon shipment or delivery, depending on contractual terms. The revenue related to the shipment or delivery of the Genio system implants is recognized at a point in time upon transfer of control. Replenishment of additional disposable patches, as well as certain patient-related components from the start of the commercialization in the United States, are supplied after the initial shipment. In such cases, a portion of the transaction price is allocated to these future deliveries based on the relative estimated standalone selling price, with revenue deferred and recognized at a point in time upon transfer of control at shipment or delivery, depending on contractual terms.

A contract liability is recognized for the payment received from a customer which is attributed to the additional replenishment of disposable patches which is recognized when control of the patches is transferred to the customer or patient quarterly following the patient implants and the revenue attributed to the future deliveries of the patient-related components in the United States.

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***Variable consideration including volume rebates***

Revenue is adjusted for variable consideration, including volume-based rebates and other factors influencing the transaction price. In certain cases, customers may qualify for a volume discount, whereby a free Genio system is granted upon meeting or exceeding a specified purchase volume over a 12-month period. The Company allocates a portion of the transaction price to the free Genio system based on its relative standalone selling price, unless it is highly probable that the purchase volume threshold will not be met.

In accordance with IFRS 15, the Company includes variable consideration in the transaction price only to the extent that it is highly probable that a significant revenue reversal will not occur once uncertainty related to that consideration is resolved.

The Company provides customers with a limited right of return for products in case of non-conformity or performance issues. Given the historically immaterial volume of returns, no revenue reduction has been recorded related to variable considerations for returns.

***Warranty obligations***

The Company provides a three-year assurance-type warranty on the Genio system for defects that existed at the time of sale. These warranties are accounted for as provisions under IAS 37 Provisions, Contingent Liabilities and Contingent Assets. These warranties does not give rise to a separate performance obligations as they do not represent a distinct service-type warranty. The impact of these warranty obligations is immaterial.

**2.17. Provisions**

A provision is recognized when the Company has a present obligation (legal or constructive) as a result of past events, when it is probable that an outflow of economic benefits will be required to settle the obligation, and when a reliable estimate of the amount can be made.

The Company has a constructive obligation arising from its business practices related to the replenishment of certain consumable components. While no contractual obligation exists, new business practices have created a valid expectation among customers that these components will continue to be supplied past the agreed contractual terms. As a result, a provision has been recognized to reflect the estimated future costs associated with fulfilling this obligation until reimbursement mechanisms are formalized. The cost is included in selling, general and administrative expenses in the consolidated income statement.

The provision is measured based on management's best estimate of the expected costs required to settle the obligation, considering available historical data and anticipated future developments. The Company will reassess the provision at each reporting date to reflect changes in expected usage, cost assumptions, and regulatory developments.

**2.18. Recoverable cash advances and other government grants**

The Company received the support from a governmental agency, in this case the Walloon Region ("Region"), under the form of recoverable cash advances. Recoverable cash advances are aimed at supporting specific development programs. As part of this support, an agreement is concluded with the Region consisting in three distinct phases being a research phase, a decision phase and an exploitation phase. During the research phase, the Company receives funds from the Region based on eligible expenses incurred by the Company.

At the end of the research phase, there is a decision phase of six months, allowing the Company to decide whether or not it will use the results of the research phase.

&nbsp;&nbsp;&nbsp;&nbsp;● If the Company decides not to use the results of the research phase, it has to notify the Region and transfer to the Region the rights associated with the research phase. Accordingly, the advances received are not to be reimbursed.

&nbsp;&nbsp;&nbsp;&nbsp;● If the Company decides to use the results of the research phase, it will enter into the exploitation phase. In such a situation, the advances received become refundable through a fixed repayment part (30%) and a variable repayment scheme (0.224% - 0.45%). The fix part is repayable unconditionally in accordance with a reimbursement plan. The variable part is dependent on the success of the project, i.e. based on a percentage on sales generated by the product that has benefited from the research.

&nbsp;&nbsp;&nbsp;&nbsp;● Reimbursements (fixed and variable) to be made by the Company (interests included) may represent up to 2 times the amount of cash advance received, depending on the level and the timing of the sales.

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At inception, recoverable cash advances are recognized as financial liability at fair value when received. To determine the fair value of the cash advances received, the Company estimates future cash outflows considering (i) assumptions regarding the estimation of the timing and the probability of the future sales or (ii) the probability that the Company will notify the Walloon Region whether it will decide or not to use the results of the research phase and (iii) an appropriate discount rate.

At inception, if the fair value of the liability exceeds the amounts of the cash received, the difference is recognized in the income statement as operating expenses. If the amount of cash received would exceed the fair value of the liability, the difference would be considered as a government grant, being recognized in the income statement as operating income on a systematic basis in order to match the expenses incurred.

Subsequently, at each closing date, the financial liability is measured at amortized cost. When the estimated contractual cash flows are changed, the entity recalculates the gross carrying amount of the financial liability as the present value of the adjusted cash flows discounted at the original effective interest rate. The difference between the recalculated carrying amount and the initial carrying amount is included in the caption "other operating income/expenses" in the consolidated income statement and in the financial expenses for the impact of the discounting. When changing the estimated contractual cash flows, the Company reviews if there are indicators, either positive or negative, influencing the estimation of the timing and level of the future sales of the products benefiting from the support of the Walloon Region.

When repayment of recoverable cash advances may be forgiven, the liability component of recoverable cash advances is treated as a government grant and taken to income only when there is reasonable assurance that the entity will meet the terms for forgiveness of the advance.

Government grants are recognized where there is reasonable assurance that the grant will be received and all attached conditions will be complied with. When the grant relates to an expense item, it is recognized as income on a systematic basis over the periods that the related costs, for which it is intended to compensate, are expensed. When the grant relates to an asset, it is deducted from the carrying amount of the asset and is reflected in the income statement as a reduction in the amortization expense of the asset concerned on a systematic basis over the life of the asset.

**2.19. Segment reporting**

Based on the organizational structure, as well as the nature of financial information available and reviewed by the Company's chief operating decision makers to assess performance and make decisions about resource allocations, the Company has concluded that its total operations represent one reportable segment. The chief operating decision maker is the CEO.

**2.20. Significant events and transactions of the reporting period**

On August 8, 2025, the Company announced that the U.S. Food and Drug Administration ("FDA") approved the Company's Genio system for the treatment of obstructive sleep apnea in a subset of patients with moderate to severe disease. Following this approval, the Company announced the official launch of U.S. commercialization of Genio.

On November 13, 2025 the Company announced financing commitments comprised of equity financing of approximately €22 million and a convertible bond financing of up to €45 million. The equity financing consists of (i) a €17 million private placement through the issuance of 4,265,714 new ordinary shares at a subscription price of €4.00 per share, and (ii) a USD 5.6 million registered direct offering through the issuance of 1,215,964 new ordinary shares at USD 4.6304 per share.

**3.** **Capital management**

The Company's objectives when managing capital are to maintain sufficient liquidity to meet its working capital requirements and fund capital investment in order to safeguard its ability to continue operating as a going concern. The capital structure of the Company consists of equity attributable to the shareholders, such as share capital, share premium, reserves and retained loss, and of borrowings. The capital of Nyxoah SA amounts to €6.5 million at December 31, 2025 (2024: €6.4 million). Total cash and cash equivalents amount to €30.0 million at December 31, 2025 (2024: €34.2 million). Term account amounts to €18.0 million at December 31, 2025 (2024: €51.4 million). The current cash situation and the anticipated cash generation are the most important parameters in assessing the capital structure. The Company's policy is to maintain a strong capital base in order to maintain investor confidence in its capacity to support the future development of its operations.

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The Company monitors capital regularly to ensure that its ability to continue operating as a going concern (we refer to 5.1) and the legal capital requirements are met and may propose capital increases to the Shareholders' Meeting to ensure the necessary capital remains intact.

**4.** **Management of financial risks**

The Company's activities expose it to a variety of financial risks. The Company's finance department identifies and evaluates the financial risks in co-operation with the operating units.

**4.1. Credit risk**

The credit risk arises mainly from trade receivables, cash and cash equivalents and deposits with banks and financial institutions. The Company's trade receivables primarily consist of amounts due from reputable hospitals and medical institutions across the different regions in which they are selling. These institutions are well-established within the healthcare industry, presenting a low credit risk profile. The Company maintains stringent credit assessment procedures and closely monitors receivables to ensure timely collections. Due to evolving commercial activities, as of Q3 2025, the Company recognizes an expected credit loss allowance on trade receivables.

Furthermore, the Company is not exposed to any material credit risk from other receivables. Other receivables are mainly the tax incentives in Australia and Belgium and there is limited risk associated to these receivables.

Below is the information about the credit risk exposure on the Company's trade receivables.

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| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| (in EUR 000) | **Total** | **Non-due** | **Less than 30 days** | **31-60 days** | **61-90 days** | **More than 91 days** |
| As at December 31, 2024 | 3382 | 1664 |  |  | 491 | 1227 |
| As at December 31, 2025 | 6018 | 4513 | 115 | 285 | 308 | 797 |

---

**4.2.** **Market risk**

Market risk is the risk that the fair value of future cash flows of a financial instrument will fluctuate because of changes in market prices. The Company's activities may expose it to changes in foreign currency exchange rates and interest rates. The Company is not exposed to any equity price risk or commodity price risk as it does not invest in these classes of investments.

**4.2.1. Foreign exchange risk**

The Company is exposed to currency risk primarily due to the expected future USD, AUD and NIS expenses that will be incurred as part of the ongoing and planned marketing, clinical trials and other related expenses. A financial risk management policy has been approved to i) generate yields on liquidity and ii) reduce the exposure to currency fluctuations with a timeline up to 24 months and by means of foreign currency swaps. The Company currently does not hedge its operational foreign exchange (FX) risk, as it is partly covered by expected future cash outflows. These outflows in USD, NIS, and AUD are forecasted or budgeted for marketing, clinical trials, and related expenses. Additionally, the Company does not hedge the risk on outstanding balances in currencies other than its functional currency.

Additionally, earnings variability arises from the translation of monetary assets and liabilities denominated in currencies other than the functional currency of the Company's subsidiaries at the rate of exchange at each closing date, the impact of which is reported as a foreign exchange gain or loss in the consolidated statements of comprehensive income.

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| | **2025 rates** | **2025 rates** | **2024 rates** | **2024 rates** | **2023 rates** | **2023 rates** |
| <br>**Currency** | **Closing** | **Average** | **Closing** | **Average** | **Closing** | **Average** |
| NIS | 3.74710 | 3.89341 | 3.78850 | 4.00670 | 3.97763 | 3.98960 |
| AUD | 1.75810 | 1.75110 | 1.67720 | 1.63971 | 1.62033 | 1.63002 |
| USD | 1.17500 | 1.12882 | 1.03890 | 1.08238 | 1.10377 | 1.08242 |

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Based on the Company's foreign currency exposures at the level of the consolidated income statement, varying the above foreign exchange rates to reflect positive and negative changes of 5 % of the NIS, AUD and USD would have the following impact:

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| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| (in EUR 000) |  | **Effect on loss (before tax)** | **Effect on loss (before tax)** | **Effect on loss (before tax)** | **Effect on pretax equity** | **Effect on pretax equity** | **Effect on pretax equity** |
| **Change in foreign exchange rate** | **Change in foreign exchange rate** | **NIS** | **USD** | **AUD** | **NIS** | **USD** | **AUD** |
| **2025** | 5% | (32) | (118) | (28) | (33) | (113) | (87) |
|  | -5% | 35 | 130 | 29 | 36 | 125 | 96 |
| **2024** | 5% | (32) | (79) | (20) | (191) | (156) | (431) |
|  | -5% | 35 | 87 | 22 | 211 | 173 | 477 |
| **2023** | 5% | (27) |  | (33) | (130) | (54) | (319) |
|  | -5% | 30 |  | 36 | 143 | 59 | 352 |

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**4.2.2. Interest rate risk**

Interest rate risk is the risk that the fair value or future cashflows of a financial instrument will fluctuate because of changes in market interest rates. The Company's exposure to interest rate risk is remote as both the EIB Finance Agreement, the convertible bonds and the term deposits and US Treasury bills have fixed interest rates.

**4.3.** **Liquidity risk**

The Company's main sources of cash inflows are obtained through capital increases, recoverable cash advances and grants, EIB finance agreement and convertible bonds. Cash is invested in low risk investments such as short-term bank deposits or savings accounts. The Company mainly makes use of liquid investment in current accounts (in Euro) or short-term deposit accounts.

The ability of the Company to maintain adequate cash reserves to support its activities in the medium term is highly dependent on the Company's ability to raise additional funds through the EIB Finance Agreement, additional capital increases or other new borrowings. As a consequence, the Company is exposed to significant liquidity risk in the medium term.

On July 3, 2024 the Company has signed a €37.5 million loan facility agreement with the European Investment Bank ("EIB"). Further details of this agreement are provided in note 18.2.

On November 13, 2025, the Company entered into a bond subscription agreement with an international financial services firm for the issuance of convertible bonds for an aggregate maximum principal amount of up to €45 million. The financing consists of a first tranche of up to €22.5 million with an option to issue a second tranche of €22.5 million at the Company's discretion. The closing for the first tranche of bonds occurred on December 18, 2025 and will mature on November 18, 2028. Further details of this agreement are provided in note **18.3**. In accordance with the terms of the bond, the Company has the option to settle the principal instalments and accrued interest in its own equity instruments or in cash. As a result, the Company is able to avoid a significant cash outflow and considers the liquidity risk associated with the bond as limited.

Please refer to note 5.1 on going concern consideration.

Contractual undiscounted maturities of financial liabilities at December 31, are as follows:

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| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  | **As at December 31** | **As at December 31** | **As at December 31** | **As at December 31** | **As at December 31** | **As at December 31** |
|  | **2025** | **2025** | **2025** | **2024** | **2024** | **2024** |
|  | **Lease**  | **Financial**  | **Trade & other**  | **Lease**  | **Financial**  | **Trade & other** |
| (in EUR 000) | **liability** | **debt\*** | **liabilities** | **liability** | **debt** | **liabilities** |
| Less than 1 year | 812 | 702 | 15578 | 1235 | 758 | 15392 |
| 1 - 5 years | 658 | 23164 |  | 2221 | 24301 | 963 |
| 5+ years |  | 4095 |  | 620 | 3599 |  |
| **Total** | **1470** | **27961** | **15578** | **4076** | **28658** | **16355** |

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(\*) Excluding the convertible bond financial debt

Balances due within 12 months equal their carrying balances, because the impact of discounting is not significant.

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**4.4.**Fair value

The carrying amount of cash and cash equivalents, trade receivables, other receivables, financial assets and other current assets approximate their value due to their short-term character.

The carrying value of current liabilities approximates their fair value due to the short-term character of these instruments. The fair value of non-current liabilities (financial debt and other non-current liabilities), excluding the derivative financial liabilities, is evaluated based on their interest rates and maturity date. These instruments have fixed interest rates and their fair value measurements are subject to changes in interest rates. The fair value measurement is classified as level 3. Please refer to note 2.9 for information on the valuation of non-current liabilities. The sensitivity on the fair value measurements of the recoverable cash advances are further detailed in note 18.1.

The derivative financial liabilities and assets which consists of foreign currency swaps are measured at fair value through profit and loss. Fair value is determined by the financial institution and is based on foreign currency swap rates and the maturity of the instrument.

The synthetic warrants are measured at fair value through profit and loss. The fair value is determined using a binomial tree with 240 monthly periods (20 years) and the following key unobservable input:

&nbsp;&nbsp;&nbsp;&nbsp;● Volatility of 66.241% , estimated based on the median of the annualized 90-day standard deviation of daily volatility of Nasdaq stock prices over the period from January 2023 to December 2025.

A 5% increase in volatility would result in an increase in fair value by €46,000, while a 5% decrease in volatility would result in a decrease in fair value by €54,000.

The prepayment option is measured at fair value through profit and loss.

The convertible bonds are measured at fair value through profit and loss. The fair value is determined using the Longstaff-Schwartz Monte Carlo valuation model. We refer to note **18.3** for the overview of the key assumptions. A 5% increase in volatility would result in an increase in fair value by €0.9 million, while a 5% decrease in volatility would result in a decrease in fair value by € 0.8 million. A 1% increase in credit spread would result in a decrease in fair value by €257,000, while a 1% decrease in credit spread would result in an increase in fair value by € 270,000.

There were no changes in the Group's valuation processes, valuation techniques, and types of inputs used in the fair value measurements during the period. There were no transfers between level 1 and level 2 fair value measurements during the period and no transfers into or out of level 3 fair value measurements.

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| | | | | |
|:---|:---|:---|:---|:---|
|  | **Carrying value** | **Carrying value** | **Fair value** | **Fair value** |
|  | **As at December 31** | **As at December 31** | **As at December 31** | **As at December 31** |
| (in EUR 000) | **2025** | **2024** | **2025** | **2024** |
| **Financial assets** |  |  |  |  |
| Other long-term receivables (level 3) | 394 | 395 | 394 | 395 |
| Prepayment option (level 3) | 91 | 112 | 91 | 112 |
| Trade and other receivables (level 3) | 6184 | 4293 | 6184 | 4293 |
| Foreign currency swaps (level 2) | 4 |  | 4 |  |
| Other current assets (level 3) | 165 | 739 | 165 | 739 |
| Cash and cash equivalents (level 1) | 30001 | 34186 | 30001 | 34186 |
| Financial assets (level 2) | 18000 | 51369 | 18000 | 51369 |
| **Financial liabilities** |  |  |  |  |
| Loan facility agreement (level 3) | 7793 | 6898 | 8165 | 7151 |
| Synthetic warrants (level 3) | 1601 | 3204 | 1601 | 3204 |
| Foreign currency swaps (level 2) |  | 353 |  | 353 |
| Recoverable cash advances (level 3) | 8609 | 8871 | 8609 | 8871 |
| Convertible bonds (level 3) | 22657 |  | 31243 |  |
| Trade and other liabilities (level 1 and 3) | 15578 | 15193 | 15578 | 15193 |

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**5.**Critical accounting estimates and assumptions

When preparing the consolidated financial statements, judgments, estimates and assumptions are made that affect the carrying amount of certain assets, liabilities, revenues and expenses. These include the going concern assessment, uncertain tax position, the recoverable cash advances, the capitalization of research and development expenses and related impairment testings, the share-based payment transactions, the finance agreement with the European Investment Bank ("EIB"), the convertible bond agreement, provision for constructive obligations, revenue and expected credit loss. These judgments, estimates and assumptions have been reviewed for each year and are reviewed on a regular basis, taking into consideration past experience and other factors deemed relevant under the then prevailing economic conditions. Changes in such conditions might accordingly result in different estimates in the Company's future consolidated financial statements.

**5.1.** **Critical judgments**

***Going concern***

The Company has operated with deficits and sustained negative cash flows since its inception as a result of the significant research and development expenses incurred for the development and regulatory approval of the Genio device. As at December 31, 2025, the Company's statement of financial position includes an accumulated loss of €306.0 million and total assets of €118.5 million. Current assets as of December 31, 2025, total €61.2 million, comprising €30.0 million in available cash and cash equivalents, and €18.0 million in marketable securities, primarily derived from previous public offerings. The Company expects to continue to incur operating losses and generate negative cash flows from operating activities, primarily due to continued investments supporting the U.S. commercial launch and the completion of its clinical trials, which are expected to be only partially offset by the Company's revenue generating activities. U.S. revenue generation began in the third quarter of 2025, following FDA marketing approval of the Genio system on August 8, 2025, which enabled the commercial launch in the United States. In November 2025, the Company raised additional capital via a €22 million equity raise and a €45 million convertible bond financing, of which the first tranche of €22.5 million was received. The second tranche of €22.5 million is expected to be available seven months post-closing subject to certain conditions (see also note **18**).

To meet the Company's future capital needs, management will continue to explore additional financing options, including the public or private issuance of equity and debt financing, as well as other funding alternatives. Additional funds remain pivotal to support the launch of the Genio product in the U.S. and the ongoing progression of research and development projects. Taking into account the November 2025 capital increases and the issuance of the first tranche bonds, the second tranche under the Company's existing credit facility with the European Investment Bank (for which the possibility to draw depends on a revenue milestone that the Company expects to meet in the first half of 2026), is expected to extend the Company's cash runway into the third quarter of 2026. If, in addition, the second tranche bonds are issued, the Company's cash runway is expected to be extended by two quarters, into the first quarter of 2027.

This raises significant doubt in respect of going concern as the current funds are not sufficient to cover a period of 12 months as from the date these financials are authorized for issuance.

Notwithstanding the above, the Board of Directors has decided that the application of the valuation rules in the assumption of a "going concern" is justified.

The consolidated financial statements have therefore been prepared on a going concern basis, which contemplates the realization of assets and the satisfaction of liabilities in the normal course of business.

***Uncertain tax position***

The tax laws applicable to the Company are complex and are subject to changes in tax landscapes, new laws, guidance, and rulings issued by the tax authorities. The Company may need to make a significant judgment whether certain tax positions taken in the tax filings are uncertain and whether it is probable that those tax positions may be challenged by the tax authorities in case of a tax audit. In making this judgment, the Company considers also third-party tax advice it has obtained.

When measuring the tax liability for uncertain tax positions, the Company need to assess the likelihood that the tax position will be challenged and determine the most likely amount (or expected value amount) that may have to be paid when the tax position is not accepted, considering any penalties and late interests payable.

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**5.2.** **Critical accounting estimates and assumptions**

***Recoverable cash advances***

The Company benefits from recoverable cash advances granted by the Walloon Region. These are in substance financial liabilities of the Company towards the Region. The determination of the amount of the financial liability is subject to a high degree of subjectivity and requires the Company to make estimates of the future sales it will derive in the future from the products that benefited from the support of the Region.

Based on these estimates, it may be concluded that the amount of the cash advance that the Company has received from the Region exceeds the amount of the financial liability estimated by the Company. In such a situation, the difference is considered as a government grant. Subsequent re-estimation of the timing of the cash outflows of the financial liability is accounted for in profit and loss.

At each closing date, the financial liability is measured at amortized cost. When the contractual cash flows estimated by management are changed, the entity recalculates the gross carrying amount of the financial liability as the present value of the modified cash flows discounted at the original effective interest rate. The fixed part to be reimbursed has been discounted with a discount rate of 5.0% and the variable part (based on sales forecasts) with a discount rate of 12.5%. Refer also to note 18.1. When changing the estimated contractual cash flows, the Company reviews if there are indicators, either positive or negative, influencing the estimation of the timing and level of the future sales of the products benefiting from the support of the Walloon Region

***Development expenses capitalized and related impairment testing***

The Company capitalizes costs for product development projects. Initial capitalization of costs is based on management's judgement that technological and economic feasibility is confirmed, usually when a product development project has reached a defined milestone according to an established project management model.

At December 31, 2019, for the first time the Company capitalized amount of development costs for the first generation of the Genio System. This amount includes costs related to the development of the Genio System which received CE Mark approval in March 2019 and related improvements. Therefore, the Company is of the opinion that, from March 2019, development expenditures do meet capitalization criteria. The Company uses an estimate for certain research and development expenses related to the Genio System and related improvements to determine the amount to be capitalized or recorded as an expense. Accordingly, the costs incurred for the first generation of the Genio System have been recognized as development assets for a total amount of €11.4 million. No additional costs have been capitalized since July 2020. In addition, the Company started capitalizing the development costs for the improved second generation of the Genio System and additional clinical studies as from July 2020. The total capitalized cost for the improved second generation and the additional clinical studies amounts to €43.9 million as of December 31, 2025 (2024: €42.0 million). See note **8**.

The development expenses capitalized have to be tested annually for impairment during the development period, prior to the start of its amortization. The Company performs the impairment test on the smallest group of assets to which it belongs for which there are separately identifiable cash flows: its cash-generating units ("CGU's"). Where the carrying value of an asset exceeds its recoverable amount (i.e. the higher of value in use and fair value less costs to sell), the asset is written down accordingly. The Company is a one product line company and the capitalized development expenses are only related to this product (Genio System).The Company determined that it has two cash generating units, Genio system launched outside the United States and Genio system launched in the United States, for which a value in use analysis has been performed.

When performing the impairment test, management needs to make significant judgments, estimates and assumptions. The Company bases its impairment calculation on detailed budgets and forecast calculations generally covering a period of four years (since the Company is in an early commercial stage). For longer periods, a growth rate is calculated and applied to future cash flows projected. See note 8.

***Share-based payments***

The Company has equity-settled share-based payment plans in place. Estimating fair value for share-based payment transactions requires determination of the most appropriate valuation model, which is dependent on the terms and conditions of the option plan. This estimate also requires determination of the most appropriate inputs to the valuation model including the expected life of the share option, volatility and dividend yield and making assumptions about them. The assumptions and models used for estimating the fair-value for share-based payment transactions are disclosed in note 17.

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***Finance agreement with the European Investment Bank ("EIB")***

The Company has entered in a finance agreement with the European Investment Bank ("EIB"). This agreement is a hybrid financial instrument consisting out of a host financial loan and 3 embedded derivatives (i.e. prepayment option, partial settlement option and synthetic warrants). The Synthetic Warrants as well as the partial settlement option derivatives are however considered to be closely related to each other and are considered as one embedded derivative to be valued hereafter named Synthetic Warrants jointly.

The prepayment option is accounted for at fair value through profit and loss. The fair value is determined by management using valuation techniques which are dependent on inputs such as credit ratings, probability of (a change in) the credit rating and discount rates.

Synthetic Warrants are valued on basis of a binomial tree model and accounted for at fair value through profit and loss. The fair value of the Synthetic Warrants, which are not traded in an active market, is determined by management using valuation techniques which are dependent on inputs such as share prices, share volume, discount rates and foreign currency exchange rates. The effective interest rate method considers the transaction cost of the loan as well as the initial fair value of the non-closely related embedded derivatives that are separated from the host financial instrument.

***Convertible bond agreement***

The Company entered into a bond subscription agreement with an international financial services firm for the issuance of convertible bonds for an aggregate maximum principal amount of up to €45 million. The financing consists of a first tranche of up to €22.5 million with an option to issue a second tranche of €22.5 million at the Company's discretion.

The Bond Instrument is accounted for as a hybrid financial instrument containing a host financial liability with embedded derivatives that are closely related (Deferred amortized payment) and embedded derivatives that are not closely related (Bond conversion right, Amortization conversion right, Share settlement option and Advanced amortized payment). The entire hybrid contract is designated at fair value through profit and loss. The fair value of the hybrid contract is determined by management using valuation techniques which are dependent on inputs such as share prices, expected volatility and discount rates. The assumptions and models used for estimating the fair value of the convertible bonds are disclosed in note 18.3.

***Provision for constructive obligations***

The recognition of provisions under IAS 37 requires management to make significant judgments regarding the existence and measurement of constructive obligations. The Company has a constructive obligation related to the ongoing replenishment of certain consumable components, based on business practices and customer expectations. The provision is estimated based on expected future costs, historical usage of disposable patches, and anticipated reimbursement timelines. Given the evolving commercial and regulatory landscape, the estimate is subject to periodic reassessment and may be adjusted as new information becomes available. The warranty provision is assessed to be immaterial.

***Revenue***

Performance obligations are satisfied when control of the Genio system is transferred to the customer, either upon shipment or delivery, depending on contractual terms. The revenue related to the shipment or delivery of the Genio system implants is recognized at a point in time upon transfer of control. Replenishment of additional disposable patches, as well as certain patient-related components from the start of the commercialization in the United States, are supplied after the initial shipment. In such cases, a portion of the transaction price is allocated to these future deliveries based on the relative estimated standalone selling price, with revenue deferred and recognized at a point in time upon transfer of control at shipment or delivery, depending on contractual terms.

The contract liability included in the consolidated balance sheet is related to revenue attributed to the additional replenishment of disposable patches which is recognized when control of the patches is transferred to the customer or patient quarterly following the patient implants and the revenue attributed to the future deliveries of the patient-related components in the United States.

***Expected credit loss***

The Company applies the simplified approach under IFRS 9 in measuring expected credit losses on contract assets. Under this approach, a lifetime expected credit loss allowance is recognized for all contract assets.

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Expected credit losses are measured using a provision matrix based on the ageing of contract assets. The provision rates are determined based on historical collection experience, adjusted for forward-looking information where relevant, and specific customer-related facts and circumstances. Older balances are subject to higher provision rates, and contract assets are fully provided for when there is no reasonable expectation of recovery.

The expected credit loss allowance is reassessed at each reporting date and updated as necessary to reflect changes in collection patterns, known credit risks and available forward-looking information.

**6.**Subsidiaries

For all years ended as at December 31, 2025, 2024 and 2023 respectively, the Company owns 100% of the shares of Nyxoah Ltd, an Israeli company located in Tel-Aviv that was incorporated in 2009 and has a share capital of NIS 1. In July 2025, the Company reorganized its global R&D function and expects to transition all ongoing R&D activities from Israel to the U.S. and Belgium.

The Company also owns 100% of the shares of Nyxoah Pty Ltd, an Australian company located in Collingwood that was incorporated in 2017 and has a share capital of AUD 100.

The Company also owns 100% of the shares of Nyxoah Inc, an American company located in Delaware that was incorporated in May 2020 and has a share capital of USD 1.

The Company also owns 100% of the shares of Nyxoah GmbH, a German company located in Eschborn that was acquired in July 2023 and has a share capital of EUR 25,000.

**7.**Property, plant and equipment

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| | | | | | |
|:---|:---|:---|:---|:---|:---|
|  | **Furniture and**  |  |  |  |  |
|  | **office**  | **Leasehold**  | **Laboratory**  | **Assets under**  |  |
| (in EUR 000) | **equipment** | **improvements** | **equipment** | **construction** | **Total** |
| **Cost** |  |  |  |  |  |
| Opening gross value January 1, 2024 | 1182 | 1314 | 1501 | 2055 | 6052 |
| Additions | 142 | 11 | 314 | 692 | 1159 |
| Disposals |  |  | (28) |  | (28) |
| Transfers |  | 488 |  | (488) |  |
| Other |  |  | 93 |  | 93 |
| Exchange differences | 32 | 23 | 22 |  | 77 |
| **Cost at December 31, 2024** | **1356** | **1836** | **1902** | **2259** | **7353** |
| Additions | 113 |  | 150 | 534 | 797 |
| Disposals | (143) | (487) | (266) |  | (896) |
| Transfers |  | 2762 |  | (2762) |  |
| Exchange differences | (23) | 5 | (2) | (1) | (21) |
| **Cost at December 31, 2025** | **1303** | **4116** | **1784** | **30** | **7233** |
| **Depreciation** |  |  |  |  |  |
| Opening accumulated depreciation January 1, 2024 | (820) | (439) | (605) |  | (1864) |
| Depreciation charge | (164) | (219) | (327) |  | (710) |
| Disposals |  |  | 21 |  | 21 |
| Exchange differences | (23) | (13) | (11) |  | (47) |
| **Depreciation at December 31, 2024** | **(1007)** | **(671)** | **(922)** | **—** | **(2600)** |
| Depreciation charge | (148) | (526) | (371) |  | (1045) |
| Disposals | 88 | 487 | 148 |  | 723 |
| Impairment loss |  | (235) | (26) |  | (261) |
| Exchange differences | 9 | (6) | (1) |  | 2 |
| **Depreciation at December 31, 2025** | **(1058)** | **(951)** | **(1172)** | **—** | **(3181)** |
| **Net book value at December 31, 2024** | **349** | **1165** | **980** | **2259** | **4753** |
| **Net book value at December 31, 2025** | **245** | **3165** | **612** | **30** | **4052** |

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In 2025, acquisitions were mainly related to the US production line under construction for an amount of €0.5 million (2024: €0.7 million), laboratory equipment for an amount of €150,000 (2024: €314,000) and furniture and office equipment for an amount of €113,000 (2024: €142,000). The total amount of purchases of property, plant and equipment in the consolidated statements of cash flow is higher than the additions due to the tax incentive relating to investments of 2025 amounting to €8,000 (2024: €6,000).

**In 2025, the Company disposed of assets within property, plant and equipment after concluding that no future economic benefits are expected. The Company recognized a loss on the disposal of €170,000, presented within selling, general and administrative expenses.**

**In 2025, the Company recognized an impairment loss of €261,000, presented within research & development expenses, on an asset within property, plant and equipment after concluding that no future economic benefits are expected.**

**In 2024, the line Other in the cost of property, plant and equipment includes a correction of the tax incentive in Belgium on the investments of 2023 for an amount of €93,000. We refer to note 10 for more details.**

There has been a transfer from assets under construction for an amount of €2.8 million to leasehold improvement (2024: €488,000).

#### The depreciation charge amounts to €1.0 million in 2025 and to € 0.7 million in 2024.
**8.**Intangible assets

---

| | | | |
|:---|:---|:---|:---|
|  | **Development** | **Patents and** |  |
| (in EUR 000) | **cost** | **licenses** | **Total** |
| **Cost** |  |  |  |
| Opening value at January 1, 2024 | 48671 | 591 | 49262 |
| Additions | 4739 |  | 4739 |
| **Cost at December 31, 2024** | **53410** | **591** | **54001** |
| Additions | 2877 |  | 2877 |
| Disposals | (916) |  | (916) |
| Other movements | (4) |  | (4) |
| **Cost at December 31, 2025** | **55367** | **591** | **55958** |
| **Amortization** |  |  |  |
| Opening amortization at January 1, 2024 | (2528) | (126) | (2654) |
| Amortization | (924) | (42) | (966) |
| **Amortization at December 31, 2024** | **(3452)** | **(168)** | **(3620)** |
| Amortization | (2187) | (43) | (2230) |
| Impairment loss | (916) |  | (916) |
| Disposals | 916 |  | 916 |
| **Amortization at December 31, 2025** | **(5639)** | **(211)** | **(5850)** |
| **Net book value at December 31, 2024** | **49958** | **423** | **50381** |
| **Net book value at December 31, 2025** | **49728** | **380** | **50108** |

---

The Company develops the Genio system. The Company started amortizing the first-generation Genio system in 2021. The costs incurred for the first generation of the Genio System have been recognized as development assets for a total amount of €11.4 million. No additional costs have been capitalized since July 2020. Following the FDA approval for the Genio system on August 8, 2025, the amortization of the related intangible assets commenced in Q3 2025. Total amortization amounted to €2.2 million for 2025 (2024: €1.0 million) and is included in Research and development expenses. The remaining amortization period of the development assets is 9 years.

**The Company continues to incur in 2025 development expenses with regard to the improved second-generation Genio system and clinical trials to obtain additional regulatory approvals in certain countries or to be able to sell the Genio System in certain countries. The total capitalized development expenses amounted to €2.9 million and €4.7 million for 2025 and 2024, respectively. The total amount of capitalization of intangible assets in the consolidated statements of cash flow is higher than the additions due to the tax incentive relating to investments of 2025 amounting to €87,000 (2024: €168,000). The total capitalized cost for the improved second generation and the additional clinical studies amounts to €43.9 million as of December 31, 2025 (2024: €42.0 million). The development of the ongoing R&D projects is expected to be finalized in 2026.**

[**Table of Contents**](#TOC)

In 2025, the Company discontinued a discrete Research and Development project previously capitalized after concluding that no future economic benefits are expected. The Company recognized an impairment loss of €0.9 million, presented within research and development expense.

**In accordance with the accounting principle, the intangible assets are tested annually for impairment during the development period. The Genio system is currently a unique product line developed by the Company and the Company determined that it has two cash generating units, Genio system outside the United States and Genio system launched in the United States, for which a value in use analysis has been performed. Based on the current operating budget as approved by the Board of Directors, the Company's management prepared cash flow forecasts, which covers a 4-year period and an appropriate extrapolation of cash flows beyond 2029.**

We refer to note 6 for more details on the reorganization of the global R&D function.

Growth rates over the forecast period are based on past performance and management's expectations of market development. Growth rates used to extrapolate cash flows beyond the budget period are consistent with forecasts included in industry reports.

Discount rates represent the current market assessment of the risks specific to each CGU, taking into consideration the time value of money and individual risks of the underlying assets that have not been incorporated in the cash flow estimates. The discount rate calculation is based on the specific circumstances of the Company and is derived from its weighted average cost of capital (WACC). The WACC takes into account both debt and equity. The cost of equity is derived from the expected return on investment by the Company's investors. The cost of debt is based on the interest-bearing borrowings the Company is obliged to service. Segment-specific risk is incorporated by applying individual beta factors. The beta factors are evaluated annually based on publicly available market data. Adjustments to the discount rate are made to factor in the specific amount and timing of the future tax flows in order to reflect a pre-tax discount rate. The discount rates over the expected term that the assets will generate economic benefits are:

---

| | | |
|:---|:---|:---|
|  | **Outside US** | **US** |
| Discount rate | 13.95% | 14.20% |

---

A sensitivity analysis has been performed concluding that a reasonable change in the WACC and/or forecasted growth rate would not lead to an impairment. The carrying amount of these intangibles assets are recoverable.

**9.**Right of use assets and lease liabilities

The Company has lease contracts for buildings and vehicles used in its operations. Leases of building have lease terms between one and nine years, while motor vehicles generally have lease terms between three and five years. Future cash outflows (potentially exposed and not reflected in the measurement of lease liabilities) arising from leases not yet commenced to which the lessee is committed amount to €4.4 million. The Company's obligations under its leases are secured by the lessor's title to the leased assets. Generally, the Company is restricted from assigning and subleasing the leased assets and some contracts require the Company to maintain certain financial ratios. The Company also has certain leases of office equipment and bicycles with low value and machinery, equipment and buildings for a short term. The Company applies the "short-term lease" and "lease of low-value assets" recognition exemptions for these leases. We refer to note 33.2 for the impact on income statement for these "short-term leases" and "leases of low-value assets".

[**Table of Contents**](#TOC)

The carrying amounts of right-of-use assets recognized and the movements during the period is as follows:

---

| | | | |
|:---|:---|:---|:---|
|  |  | **Motor**  |  |
| (in EUR 000) | **Building** | **vehicles** | **Total** |
| **Cost** |  |  |  |
| Opening value at January 1, 2024 | 4604 | 1383 | 5987 |
| Additions | 326 | 332 | 658 |
| Disposal |  | (173) | (173) |
| Lease modification | (11) | (17) | (28) |
| Exchange difference | 139 | 2 | 141 |
| **Cost at December 31, 2024** | **5058** | **1527** | **6585** |
| Additions |  | 90 | 90 |
| Disposal | (52) | (268) | (320) |
| Lease modification | (3219) | 9 | (3210) |
| Exchange difference | (87) | (5) | (92) |
| **Cost at December 31, 2025** | **1700** | **1353** | **3053** |
| **Depreciation** |  |  |  |
| Opening value at January 1, 2024 | (1661) | (538) | (2199) |
| Depreciation charge | (674) | (368) | (1042) |
| Disposal |  | 173 | 173 |
| Lease modification | 22 | 36 | 58 |
| Exchange difference | (79) |  | (79) |
| **Depreciation at December 31, 2024** | **(2392)** | **(697)** | **(3089)** |
| Depreciation charge | (809) | (400) | (1209) |
| Disposal | 39 | 268 | 307 |
| Lease modification | 2180 |  | 2180 |
| Exchange difference | 50 | 1 | 51 |
| **Depreciation at December 31, 2025** | **(932)** | **(828)** | **(1760)** |
| **Net book value at December 31, 2024** | **2666** | **830** | **3496** |
| **Net book value at December 31, 2025** | **768** | **525** | **1293** |

---

In 2025, the Company did enter into new lease agreements for €90,000 compared to €0.7 million in 2024. The lease modification relates to (i) a decrease in the lease term of the clean room in Belgium and (ii) a decrease in the lease term of the building in Israel. The decrease in the lease term of the clean room resulted in a reduction of the right-of-use asset of €0.6 million and a corresponding reduction of the lease liability of €0.6 million. The decrease in the lease term of the building in Israel resulted in a reduction of the right-of-use asset of €0.6 million and a reduction of the lease liability of €0.7 million.

The repayments of lease liabilities amounted to €1.3 million (2024: €1.2 million) The depreciations on the right of use assets amounted to €1.2 million and €1.0 million for 2025 and 2024, respectively.

For the year ended December 31, 2025, the Company recognized a gain on disposal of €8,000 (2024: no gain or loss on disposal) and a gain on modification of €119,000.

[**Table of Contents**](#TOC)

The maturity analysis of lease liabilities is disclosed in note **4.3**.

---

| | | |
|:---|:---|:---|
| (in EUR 000) | **2025** | **2024** |
| **Lease debt at January 1** | **3680** | **3967** |
| New lease debts | 90 | 658 |
| Rent expense paid | (1252) | (1208) |
| Accretion of interest | 119 | 157 |
| Disposal | (21) |  |
| Lease modification | (1149) | 30 |
| Exchange differences | (51) | 76 |
| **Lease debt at December 31** | **1416** | **3680** |

---

---

| | | |
|:---|:---|:---|
|  | **As at December 31** | **As at December 31** |
| (in EUR 000) | **2025** | **2024** |
| Non-current lease liabilities | 637 | 2562 |
| Current lease liabilities | 779 | 1118 |
| **Total** | **1416** | **3680** |

---

**10.** **Other long-term receivables**

---

| | | |
|:---|:---|:---|
|  | **As at December 31** | **As at December 31** |
| (in EUR 000) | **2025** | **2024** |
| R&D tax incentive | 1233 | 1110 |
| Prepayment option | 91 | 112 |
| Cash guarantees | 394 | 395 |
| **Total other long term receivables** | **1718** | **1617** |

---

The other long-term receivables consist of cash guarantees for an amount of €0.4 million (2024: €395,000), a prepayment option valued at €91,000 (2024: €112,000) and an R&D tax incentive in Belgium for an amount of €1.2 million (2024: €1.1 million) related to certain development activities and clinical trials. The Company recognizes the research and development incentive as a long-term receivable and as a deduction from the carrying amount of the (in) tangible asset.

For further details regarding the prepayment option, refer to note **18.2**.

The R&D tax incentive recorded as at December 31, 2025 pertains to investments made as from 2022 in both tangible and intangible assets. These incentives are expected to be received 5 years after the investments are made. However, following the Law of May 12, 2024 (Belgian Gazette May 29, 2024), the Belgian R&D tax credit regime has been amended. As of 2024, the R&D tax incentive will be refunded after 4 years instead of 5 years. The long-term receivable as at December 31, 2024, also includes an adjustment of the R&D tax incentive for investments made in 2023. For further details, refer to note 26.

**11.**Inventory

---

| | | |
|:---|:---|:---|
|  | **As at December 31** | **As at December 31** |
| (in EUR 000) | **2025** | **2024** |
| Raw materials | 1315 | 1080 |
| Work in progress | 1851 | 2546 |
| Finished goods | 1494 | 1090 |
| **Total Inventory** | **4660** | **4716** |

---

The increase in raw materials and finished goods is offset by a decrease in work in progress. For the year ended December 31, 2025 and 2024 the Company did not recognize any expenses for inventory write-offs since the inventory level as per year-end is expected to be sold in the foreseeable future.

[**Table of Contents**](#TOC)

**12.** **Trade receivables, contract assets and other receivables**

---

| | | |
|:---|:---|:---|
|  | **As at December 31** | **As at December 31** |
| (in EUR 000) | **2025** | **2024** |
| Trade receivables | 5254 | 3382 |
| Contract assets | 764 |  |
| Allowance for expected credit loss | (503) |  |
| Advance payments | 307 | 734 |
| R&D incentive receivable (Australia) | 111 | 155 |
| VAT receivable | 614 | 741 |
| Current tax receivable | 811 | 967 |
| Foreign currency swaps and forwards  | 4 |  |
| Other | 362 | 177 |
| **Total trade receivables, contract assets and other receivables** | **7724** | **6156** |

---

The increase of €1.6 million in trade receivables, contract assets and other receivables as at December 31, 2025 is mainly the result of an increase in trade receivables and contract assets of €2.6 million, as a result of an increase in revenue by the Company. The increase is offset by a decrease in advance payments of €427,000, a decrease in VAT receivable of €127,000 and a decrease in current tax receivables of €156,000.

For the period ended December 31, 2025, an allowance for expected credit loss on contract assets was booked for an amount of €0.5 million. This amount is included in Selling, General and Administrative expenses.

The Company can include unbilled receivables in its accounts receivable balance. Generally, these receivables represent earned revenue from products delivered to customers, which will be billed in the next billing cycle. All amounts are considered collectible and billable. As at December 31, 2025 and December 31, 2024, there were no unbilled receivables included in the trade receivables.

As of June 30, 2025, the Company has reclassified €1.5 million trade receivables to contract assets in connection with certain customer contracts for the Genio system. As at December 31, 2025, the contract assets amounts to €0.8 million. Under these contracts, the Company has transferred control of the Genio system to the customer and issued the related invoices. However, under the contractual terms, the invoices become payable upon the implantation of the Genio system in the patient by the customer. As the right to consideration is therefore not unconditional, the related amounts do not meet the criteria for recognition as trade receivables in accordance with IFRS 15. No corrections on December 31, 2024 figures were performed as considered immaterial in view of presentation in the financial statements.

R&D incentive receivables relates to incentives received in Australia as support to the clinical trials and the development of the Genio system.

The current tax receivable relates to excess payment of corporate income tax in Belgium.

We refer to note 21.1 for more details on the foreign currency swaps.

**13.** **Other current assets**

---

| | | |
|:---|:---|:---|
|  | **As at December 31** | **As at December 31** |
| (in EUR 000) | **2025** | **2024** |
| Deferred charges | 663 | 918 |
| Accrued income | 165 | 738 |
| **Total other current assets** | **828** | **1656** |

---

The decrease of €0.8 million in other current assets is mainly due to a decrease in accrued income amounting to €0.6 million. The decrease can be explained by a decrease in accrued income related to the term deposits due to a decrease in the number of term deposits outstanding.

[**Table of Contents**](#TOC)

**14.**Cash and cash equivalents

---

| | | |
|:---|:---|:---|
|  | **As at December 31** | **As at December 31** |
| (in EUR 000) | **2025** | **2024** |
| Short term deposit | 22131 | 28220 |
| Current accounts | 7870 | 5966 |
| **Total cash and cash equivalents** | **30001** | **34186** |

---

Cash and cash equivalents decreased to €30.0 million as at December 31, 2025, compared to €34.2 million as at December 31, 2024 with a decrease of short term deposits by €6.1 million, offset by an increase of current accounts by €1.9 million. The short term deposits relate to term accounts with an initial maturity of 3 months or less, measured at amortized costs.

**15.**Financial assets

Current financial assets relate to term accounts with an initial maturity longer than 3 months but less than 12 months measured at amortized costs.

As at December 31, 2025 the total current financial assets amounts to €18.0 million and consists of EUR current financial assets. As at , , there are no USD current financial assets which could generate a foreign currency exchange gain or loss in the financial results in accordance with the fluctuations of the USD/EUR exchange rate as the Company's functional currency is EUR.

In 2025, the Company entered into USD term deposits and US Treasury bills for a total amount of USD 21.3 million (€19.0 million) and €23.0 million. During the period ended as at, December 31, 2025, USD 68.7 million (€61.2 million) and €10.8 million reached maturity and is subsequently held as cash.

As at December 31, 2024 the current financial assets consists of USD 47.4 million (€45.6 million), which could generate a foreign currency exchange gain or loss in the financial results in accordance with the fluctuations of the USD/EUR exchange rate as the Company's functional currency is EUR, and €5.8 million. The total amount of term deposits as at December 31, 2024, amounts to €51.4 million.

In 2024, the Company entered into USD term deposits and US Treasury bills for a total amount of USD 77.4 million (€71.6 million) and €26.3 million. During the period ended as at, December 31, 2024, USD 64.4 million (€59.8 million) and €25.5 million reached maturity and is subsequently held as cash.

**16.**Share capital, share premium, reserves

16.1. Share capital and share premium

The number of shares and the par value in the paragraph below take into account resolutions adopted by the shareholders' meeting of February 21, 2020. All existing preferred shares were converted into common shares, and then a share split of 500:1 was approved by the shareholders' meeting. The tables and comments below reflect the number of shares after the share split of 500:1 as of January 1, 2020.

As part of the IPO on September 21, 2020, the Company incurred direct-attributable transaction costs of €6.5 million which have been deducted from the share premium.

As part of the IPO on July 7, 2021, the Company incurred direct-attributable transaction costs of €7.6 million which have been deducted from the share premium.

As of December 31, 2024, the share capital of the Company amounts to €6.4 million represented by 37,427,265 shares, and the share premium amounts to €332.6 million (before deduction of the transaction costs).

As of December 31, 2025, the share capital of the Company amounts to €6.5 million represented by 43,026,460 shares, and the share premium amounts to €354.5 million (before deduction of the transaction costs).

[**Table of Contents**](#TOC)

Evolution of the share capital and share premium ended December 31, 2025 and 2024:

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
|  | **Common** | **Total of**  | **Share capital**  | **Share capital** | **Share premium** |
| (Number of shares except otherwise stated) | **shares** | **shares** | **per share** | **(in EUR 000)** | **(in EUR 000)** |
| **January 1, 2024** | **28673985** | **28673985** | **—** | **4926** | **260631** |
| March 6, 2024 - Exercise warrants | 8650 | 8650 | 0.17 | 1 | 61 |
| April 17, 2024 - Exercise warrants | 3000 | 3000 | 0.17 | 1 | 16 |
| May 28, 2024 - Capital increase in cash | 5374755 | 5374755 | 0.17 | 923 | 44946 |
| June 3, 2024 - Capital increase in cash | 300000 | 300000 | 0.17 | 52 | 2506 |
| June 24, 2024 - Exercise warrants | 12625 | 12625 | 0.17 | 2 | 66 |
| September 3, 2024 - Exercise warrants | 13750 | 13750 | 0.17 | 2 | 72 |
| September 25, 2024 - Exercise warrants | 2250 | 2250 | 0.17 | 1 | 12 |
| October 9, 2024 - Capital increase in cash | 3000000 | 3000000 | 0.17 | 515 | 24071 |
| November 15, 2024 - Exercise warrants | 38250 | 38250 | 0.17 | 7 | 198 |
| **December 31, 2024** | **37427265** | **37427265** | **—** | **6430** | **332579** |
| May 12, 2025 - Exercise warrants | 2000 | 2000 | 0.17 |  | 10 |
| June 13, 2025 - Exercise warrants | 6375 | 6375 | 0.17 | 1 | 33 |
| July 8, 2025 - Exercise warrants | 5500 | 5500 | 0.17 | 1 | 29 |
| September 26, 2025 - Exercise RSU warrants | 103642 | 103642 | 0.17 | 18 |  |
| November 18, 2025 - Capital increase in cash | 5189428 | 5189428 | 0.01 | 52 | 20706 |
| November 20, 2025 - Capital increase in cash | 292250 | 292250 | 0.01 | 3 | 1166 |
| **December 31, 2025** | **43026460** | **43026460** |  | **6505** | **354523** |

---

On March 6, 2024, pursuant to the exercise of warrants, the Company issued 8,650 new shares for an aggregate capital increase of €62,000 (including share premium).

On April 17, 2024, pursuant to the exercise of warrants, the Company issued 3,000 new shares for an aggregate capital increase of €17,000 (including share premium).

On May 28, 2024, the Company issued 5,374,755 new shares for an aggregate capital increase of €45.9 million (including share premium) in the framework of an underwritten public offering in the United States, which included shares sold in a private offering to certain qualified or institutional investors outside the United States. 1,996,187 shares were subscribed to in euro at a share price of €8.54 per share. 3.378.568 shares were subscribed to in US dollars, at a share price of $9.25 per share.

On June 3, 2024, the Company issued 300,000 new shares for an aggregate capital increase of €2.6 million (including share premium) as a result of the exercise by the underwriters of the May 28, 2024 capital increase to exercise their option to purchase additional shares ("greenshoe"). All 300,000 shares were subscribed to in US dollars at a share price of $9.25 per share.

The proceeds of the May 28 and June 3, 2024 capital increases will be used for general corporate purposes.

On June 24, 2024, pursuant to the exercise of warrants, the Company issued 12,625 new shares for an aggregate capital increase of €68,000 (including share premium).

On September 3, 2024, pursuant to the exercise of warrants, the Company issued 13,750 new shares for an aggregate capital increase of €74,000 (including share premium).

On September 25, 2024, pursuant to the exercise of warrants, the Company issued 2,250 new shares for an aggregate capital increase of €13,000 (including share premium).

On October 9, 2024, the Company issued 3,000,000 new shares for an aggregate capital increase of €24.6 million (including share premium). The Company raised $27.0 million in gross proceeds pursuant to the Company's $50 million at-the-market ("ATM") program established on December 22, 2022 at an issue price equal to the market price on the Nasdaq Global Market at the time of the sale. The proceeds will be used to meet demand outside the U.S. and in the U.S.

[**Table of Contents**](#TOC)

On November 15, 2024, pursuant to the exercise of warrants, the Company issued 38,250 new shares for an aggregate capital increase of €205,000 (including share premium).

As part of the above capital increases, the Company incurred direct-attributable transaction costs of €3.7 million which were deducted from the share premium. The proceeds from the capital increase net of transaction costs amounted to €71.5 million.

On May 12, 2025, pursuant to the exercise of warrants, the Company issued 2,000 new shares for an aggregate capital increase of €10,000 (including share premium).

On June 13, 2025, pursuant to the exercise of warrants, the Company issued 6,375 new shares for an aggregate capital increase of €34,000 (including share premium).

On July 8, 2025, pursuant to the exercise of warrants, the Company issued 5,500 new shares for an aggregate capital increase of €30,000 (including share premium).

On September 26, 2025, pursuant to the exercise of RSU warrants, the Company issued 103,642 new shares for an aggregate capital increase of €18,000 (no share premium).

On November 18, 2025, the Company issued 5,189,428 new shares for an aggregate capital increase of €20.8 million (including share premium). All shares were subscribed to in EUR at a share price of €4 per share.

On November 20, 2025, the Company issued 292,250 new shares for an aggregate capital increase of €1.2 million (including share premium). All shares were subscribed to in EUR at a share price of €4 per share.

As part of above capital increases, the Company incurred direct-attributable transaction costs of €1.2 million which have been deducted from the share premium. The proceeds from the capital increase net of transaction costs amounted to €21.9 million.

16.2. Reserves

The reserves include the share-based payment reserve (see note 17), other comprehensive income and the retained loss. Retained loss is comprised of primarily of accumulated losses, other comprehensive income is comprised of currency translation reserves and remeasurements of post-employment benefit obligations.

The movement in other comprehensive income for the year ended December 31, 2025 and 2024 is detailed in the table below:

---

| | | | |
|:---|:---|:---|:---|
|  |  | **Post-** |  |
|  | **Currency** | **employment** |  |
|  | **translation** | **benefit** |  |
| (in EUR 000) | **reserve** | **obligations** | **Total** |
| Opening value at January 1, 2024 | 54 | 83 | 137 |
| **Items that may be subsequently reclassified to profit or loss (net of tax)** |  |  |  |
| Currency translation differences | 766 |  | 766 |
| **Items that may not be subsequently reclassified to profit or loss (net of tax)** |  |  |  |
| Remeasurements of post-employment benefit obligations |  | 11 | 11 |
| **Total other comprehensive income at December 31, 2024** | **820** | **94** | **914** |
| **Items that may be subsequently reclassified to profit or loss (net of tax)** |  |  |  |
| Currency translation differences | 228 |  | 228 |
| **Items that may not be subsequently reclassified to profit or loss (net of tax)** |  |  |  |
| Remeasurements of post-employment benefit obligations |  | (18) | (18) |
| **Total other comprehensive income at December 31, 2025** | **1048** | **76** | **1124** |

---

[**Table of Contents**](#TOC)

**17.**Share-based compensation

As at December 31, 2025, the Company has five outstanding equity-settled share-based incentive plans, including (i) the 2021 warrants plan (the 2021 plan), (ii) the 2022 warrants plan (the 2022 plan), (iii) the 2024 warrants plan (the 2024 plan), (iv) the 2025 warrants plan (the 2025 plan) and (v) the 2025-2 warrants plan (the 2025-2 plan). For the 2018 and 2020 warrants plan, no warrants were outstanding anymore as at December 31, 2025. The Company had an extraordinary shareholders' meeting on February 21, 2020, where it was decided to achieve a share split in a ratio of 500: 1. Per warrant issued before February 21, 2020, 500 common shares will be issuable. For presentation purposes the tables and comments below reflect the number of shares the warrants give right to across all plans.

In accordance with the terms of the various plans, all warrants that had not yet vested before, vested on September 7, 2020, i.e. ten business days prior to the closing of the IPO on September 21, 2020.

The changes of the year for the equity-settled warrant plans are as follows:

---

| | | |
|:---|:---|:---|
| **Number of shares (after share split) warrants give right to across all plans** | **2025** | **2024** |
| Outstanding at January 1 | 2258319 | 1635606 |
| Granted | 1218754 | 1297713 |
| Forfeited | (84502) | (474000) |
| Exercised | (13875) | (78525) |
| Expired | (170877) | (122475) |
| **Outstanding at December 31** | **3207819** | **2258319** |
| **Exercisable at December 31** | **1893182** | **1453727** |

---

**17.1. Description of the equity-settled share-based incentive plans**

***2018 Plan***

On December 12, 2018, the shareholders' meeting of the Company approved the issuance of 525 warrants, giving each the right to subscribe to one common share of the Company before share split (500 shares after the share split). Under this plan, up to 525 warrants can be issued. By consequence, the Company can issue up to 525 common shares before the share split (262,500 shares after the share split) if all warrants are exercised.

The total amount of warrant holders under the 2018 Plan cannot exceed 150 individuals. Unless the Board of Directors determines otherwise, the 2018 ESOP Warrants are not transferable inter vivos once they have been granted to a holder of 2018 ESOP Warrants, and may not be pledged or encumbered with any security, pledge or right in rem in any other way, either voluntarily, by operation of law or otherwise. The exercise price of each warrant cannot be less than €3,259.91. Taking into consideration the share split, this would result in an exercise price of €6.52 per share. The key features of the warrants granted under the 2018 Plan are as follows (i) each warrant could be exercised for one share before share split (500 shares after the share split), (ii) the warrants are granted for free, (iii) the warrants have a term of maximum ten years since the issue date, (iv) the only vesting condition is that the holder is still an employee of the Company at the vesting date, and (v) unless the Board of Directors determines otherwise, the warrants vest as follows: 34.0 % at the grant date, 33.0 % at the first anniversary of the grant date, 33.0 % at the second anniversary. Accordingly, the fair value of the plan is expensed over the vesting period. As a result of the IPO, all warrants that had not yet vested before, vested on September 7, 2020, i.e. ten business days prior to the closing of the IPO on September 21, 2020.

In April 2020, 33 warrants were granted under the 2018 Plan with an exercise price of €5,966.59 (exercise price of €11.93 per share after the share split) while the previous warrants of the 2018 Plan have an exercise price of €3,259.91 (exercise price of €6.52 per share after the share split).

[**Table of Contents**](#TOC)

The status of the 2018 warrant plan at December 31 is as follows:

---

| | | |
|:---|:---|:---|
| **Number of shares (after share split) warrants give right to for 2018 Plan** | **2025** | **2024** |
| Outstanding at January 1 |  | 50000 |
| Granted |  |  |
| Forfeited |  | (50000) |
| Exercised |  |  |
| Expired |  |  |
| **Outstanding at December 31** | **—** | **—** |
| **Exercisable at December 31** | **—** | **—** |

---

There are no outstanding warrants as at December 31, 2025.

***2020 Plan***

On February 21, 2020, 550,000 warrants were issued, giving each the right to subscribe to one common share of the Company. By consequence, the Company can issue up to 550,000 common shares if all warrants are exercised.

The total number of warrant holders under the 2020 Plan cannot exceed 150 persons. Unless the Board of Directors determines otherwise, the 2020 ESOP Warrants are not transferable inter vivos once they have been granted to a holder of 2020 ESOP Warrants, and may not be pledged or encumbered with any security, pledge or right in rem in any other way, either voluntarily, by operation of law or otherwise. The key features of the warrants granted under the 2020 Plan are as follows (i) each warrant could be exercised for one share, (ii) the warrants are granted for free, (iii) the warrants have a term of maximum ten years since the issue date, (iv) the only vesting condition is that the holder is still an employee of the Company at the vesting date, and (v) unless the Board of Directors determines otherwise, the warrants vest as follows: 34.0 % at the grant date, 33.0 % at the first anniversary of the grant date, 33.0 % at the second anniversary. Accordingly, the fair value of the plan is expensed over the vesting period. As a result of the IPO, all warrants that had not yet vested before, vested on September 7, 2020, i.e. ten business days prior to the closing of the IPO on September 21, 2020. The exercise price of each warrant amounts to €11.94.

The status of the 2020 warrant plan at December 31 is as follows:

---

| | | |
|:---|:---|:---|
| **Number of shares/warrants give right to for 2020 Plan** | **2025** | **2024** |
| Outstanding at January 1 | 30000 | 410500 |
| Granted |  |  |
| Forfeited |  | (330500) |
| Exercised |  | (2400) |
| Expired | (30000) | (47600) |
| **Outstanding at December 31** | **—** | **30000** |
| **Exercisable at December 31** | **—** | **30000** |

---

In 2025, 30,000 warrants have been expired because the warrants were not exercised by employees within 3 months after having left the company. Per December 31, 2025, there are no remaining warrants outstanding or exercisable.

***2021 Plan***

On September 8, 2021, the Board of Directors, within the framework of the authorized capital, issued 1,400,000 warrants, giving each the right to subscribe to one common share of the Company. By consequence, the Company can issue up to 1,400,000 common shares if all warrants are exercised.

[**Table of Contents**](#TOC)

The total number of warrant holders under the 2021 Plan cannot exceed 150 persons. Unless the Board of Directors determines otherwise, the 2021 ESOP Warrants are not transferable inter vivos once they have been granted to a holder of 2021 ESOP Warrants, and may not be pledged or encumbered with any security, pledge or right in rem in any other way, either voluntarily, by operation of law or otherwise. The key features of the warrants granted under the 2021 Plan are as follows (i) each warrant could be exercised for one share, (ii) the warrants are granted for free, (iii) the warrants have a term of maximum ten years since the issue date, (iv) the only vesting condition is that the holder is still an employee of the Company at the vesting date, and (v) unless the Board of Directors determines otherwise, the warrants vest as follows: 25.0 % at the grant date, 25.0 % at the first anniversary of the grant date, 25.0 % at the second anniversary of the grant date, 25.0 % at the third anniversary of the grant date. Accordingly, the fair value of the plan is expensed over the vesting period. The exercise price of the 2021 ESOP Warrants granted in 2021 amounts to €25.31.

On September 17, 2021, 319,240 warrants were granted from which 29,500 warrants were not accepted. On October 27, 2021 111,500 warrants were granted which were all accepted.

On February 21, 2022 219,000 warrants were granted from which 5,000 warrants were not accepted. On May 14, 2022 and June 8, 2022 respectively 72,500 and 175,000 warrants were granted which were all accepted. On August 8, 2022, 75,000 warrants were granted which were all accepted.

On March 24, 2023, the Company reduced the exercise price of 75% of the warrants previously granted to warrant holders under the 2021 Warrants Plan to 5.42 EUR to reflect the decrease in the company's share price. For the remaining 25% of the warrants previously granted under the 2021 Warrants Plan, the exercise price will remain unchanged. All other terms and conditions of the re-priced warrants remain unchanged to the original option agreement.

On March 24, 2023,200,862 warrants were granted which were all accepted. On April 12, 2023 and June 14, 2023 respectively 100,000 and 161,398 warrants were granted which were all accepted.

The status of the 2021 warrant plan at December 31 is as follows:

---

| | | |
|:---|:---|:---|
| **Number of shares/warrants give right to for 2021 Plan** | **2025** | **2024** |
| Outstanding at January 1 | 930875 | 1119250 |
| Granted |  |  |
| Forfeited | (10000) | (51125) |
| Exercised | (11375) | (63625) |
| Expired | (80125) | (73625) |
| **Outstanding at December 31** | **829375** | **930875** |
| **Exercisable at December 31** | **794785** | **800819** |

---

In 2025, a total of 11,375 warrants were exercised, 10,000 warrants have been forfeited because the warrants were not vested by employees leaving the company and 80,125 warrants were expired because the warrants were not exercised by employees within 3 months after having left the company. The remaining number of warrants as at December 31, 2025 equals 829,375 representing 829,375 shares.

***2022 Plan***

On December 28, 2022, the Board of Directors, within the framework of the authorized capital, issued 700,000 warrants, giving each the right to subscribe to one common share of the Company. By consequence, the Company can issue up to 700,000 common shares if all warrants are exercised.

[**Table of Contents**](#TOC)

The total number of warrant holders under the 2022 Plan cannot exceed 150 persons. Unless the Board of Directors determines otherwise, the 2022 ESOP Warrants are not transferable inter vivos once they have been granted to a holder of 2022 ESOP Warrants, and may not be pledged or encumbered with any security, pledge or right in rem in any other way, either voluntarily, by operation of law or otherwise. The key features of the warrants granted under the 2022 Plan are as follows (i) each warrant could be exercised for one share, (ii) the warrants are granted for free, (iii) the warrants have a term of maximum ten years since the issue date, (iv) the only vesting condition is that the holder is still an employee of the Company at the vesting date, and (v) unless the Board of Directors (or the shareholders' meeting if warrants are granted to directors) determines otherwise, the warrants vest as follows: 25.0 % at the grant date, 25.0 % at the first anniversary of the grant date, 25.0 % at the second anniversary of the grant date, 25.0 % at the third anniversary of the grant date. Accordingly, the fair value of the plan is expensed over the vesting period.

On June 14, 2023 and October 20, 2023 respectively 13,602 and 42,254 warrants were granted and all were accepted. The June grant (of 13,602 warrants granted to the directors) vested for 100% at the first anniversary of the grant.

On February 1, 2024, on April 21, 2024 and on August 2, 2024 respectively 300,250; 85,000 and 258,894 warrants were granted and all warrants were accepted.

The status of the 2022 warrant plan at December 31 is as follows:

---

| | | |
|:---|:---|:---|
| **Number of shares/warrants give right to for 2022 Plan** | **2025** | **2024** |
| Outstanding at January 1 | 643875 | 55856 |
| Granted |  | 644144 |
| Forfeited | (39627) | (42375) |
| Exercised | (2500) | (12500) |
| Expired | (36627) | (1250) |
| **Outstanding at December 31** | **565121** | **643875** |
| **Exercisable at December 31** | **419246** | **376186** |

---

In 2025, a total of 2,500 warrants were exercised, 39,627 warrants have been forfeited because the warrants were not vested by employees leaving the company and 36,627 warrants were expired because the warrants were not exercised by employees within 3 months after having left the company. The remaining number of warrants as per December 31, 2025 equals 565,121 representing 565,121 shares.

***2024 Plan***

On July 31, 2024, the Board of Directors, within the framework of the authorized capital, issued 1,000,000 warrants, giving each the right to subscribe to one common share of the Company. By consequence, the Company can issue up to 1,000,000 common shares if all warrants are exercised.

The total number of warrant holders under the 2024 Plan cannot exceed 150 persons. Unless the Board of Directors determines otherwise, the 2024 ESOP Warrants are not transferable inter vivos once they have been granted to a holder of 2024 ESOP Warrants, and may not be pledged or encumbered with any security, pledge or right in rem in any other way, either voluntarily, by operation of law or otherwise. The key features of the warrants granted under the 2024 Plan are as follows (i) each warrant could be exercised for one share, (ii) the warrants are granted for free, (iii) the warrants have a term of maximum ten years since the issue date,, (iv) the only vesting condition is that the holder is still an employee of the Company at the vesting date, and (v) unless the Board of Directors (or the shareholders' meeting if warrants are granted to directors) determines otherwise, the warrants vest as follows: 25.0 % at the grant date, 25.0 % at the first anniversary of the grant date, 25.0 % at the second anniversary of the grant date, 25.0 % at the third anniversary of the grant date. Accordingly, the fair value of the plan is expensed over the vesting period.

On August 2, 2024, September 18, 2024 and November 25, 2024 respectively 221,606; 105,000 and 326,963 warrants were granted and all were accepted.

[**Table of Contents**](#TOC)

On February 1, 2025, 346,431 warrants were granted, of which 329,431 were accepted and 17,000 were refused. On September 6, 2025, 15,000 warrants were granted and all were accepted.

The status of the 2024 warrant plan at December 31 is as follows:

---

| | | |
|:---|:---|:---|
| **Number of shares/warrants give right to for 2024 Plan** | **2025** | **2024** |
| Outstanding at January 1 | 653569 |  |
| Granted | 344431 | 653569 |
| Forfeited | (31125) |  |
| Exercised |  |  |
| Expired | (4125) |  |
| **Outstanding at December 31** | **962750** | **653569** |
| **Exercisable at December 31** | **463070** | **246722** |

---

In 2025, no warrants were exercised, 31,125 warrants have been forfeited because the warrants were not vested by employees leaving the company and 4,125 warrants were expired because the warrants were not exercised by employees within 3 months after having left the company. The remaining number of warrants as at December 31, 2025 equals 962,750 representing 962,750 shares.

***2025 Plan***

On January 30, 2025, the Board of Directors, within the framework of the authorized capital, issued 805,000 warrants, giving each the right to subscribe to one common share of the Company. By consequence, the Company can issue up to 805,000 common shares if all warrants are exercised.

The total number of warrant holders under the 2025 Plan cannot exceed 150 persons. Unless the Board of Directors determines otherwise, the 2025 ESOP Warrants are not transferable inter vivos once they have been granted to a holder of 2025 ESOP Warrants, and may not be pledged or encumbered with any security, pledge or right in rem in any other way, either voluntarily, by operation of law or otherwise. The key features of the warrants granted under the 2025 Plan are as follows (i) each warrant could be exercised for one share, (ii) the warrants are granted for free, (iii) the warrants have a term of maximum ten years since the issue date, (iv) the only vesting condition is that the holder is still an employee of the Company at the vesting date, and (v) unless the Board of Directors (or the shareholders' meeting if warrants are granted to directors) determines otherwise, the warrants vest as follows: 25.0% at the grant date, 25.0% at the first anniversary of the grant date, 25.0% at the second anniversary of the grant date, 25.0% at the third anniversary of the grant date. Accordingly, the fair value of the plan is expensed over the vesting period.

On February 1, 2025, 233,943 warrants were granted, of which 223,943 were accepted and 10,000 were refused. On March 14, 2025, April 8, 2025, May 5, 2025, September 6, 2025, and October 13, 2025, respectively 45,000; 30,000; 30,000; 465,380 and 10,000 warrants were granted and all were accepted.

The status of the 2025 warrant plan at December 31 is as follows:

---

| | | |
|:---|:---|:---|
| **Number of shares/warrants give right to for 2025 Plan** | **2025** | **2024** |
| Outstanding at January 1 |  |  |
| Granted | 804323 |  |
| Forfeited | (3750) |  |
| Exercised |  |  |
| Expired | (20000) |  |
| **Outstanding at December 31** | **780573** | **—** |
| **Exercisable at December 31** | **198581** | **—** |

---

In 2025, no warrants were exercised, 3,750 warrants have been forfeited because the warrants were not vested by employees leaving the company and 20,000 warrants were expired because the warrants were not exercised by employees within 3 months after having left the company. The remaining number of warrants as at December 31, 2025 equals 780,573 representing 780,573 shares.

[**Table of Contents**](#TOC)

***2025-2 Plan***

On October 13, 2025, the Board of Directors, within the framework of the authorized capital, issued 760,000 warrants, giving each the right to subscribe to one common share of the Company. By consequence, the Company can issue up to 760,000 common shares if all warrants are exercised.

The total number of warrant holders under the 2025-2 Plan cannot exceed 150 persons. Unless the Board of Directors determines otherwise, the 2025-2 ESOP Warrants are not transferable inter vivos once they have been granted to a holder of 2025-2 ESOP Warrants, and may not be pledged or encumbered with any security, pledge or right in rem in any other way, either voluntarily, by operation of law or otherwise. The key features of the warrants granted under the 2025-2 Plan are as follows (i) each warrant could be exercised for one share, (ii) the warrants are granted for free, (iii) the warrants have a term of maximum ten years since the issue date, (iv) the only vesting condition is that the holder is still an employee of the Company at the vesting date, and (v) unless the Board of Directors (or the shareholders' meeting if warrants are granted to directors) determines otherwise, the warrants vest as follows: 25.0% at the grant date, 25.0% at the first anniversary of the grant date, 25.0% at the second anniversary of the grant date, 25.0% at the third anniversary of the grant date. Accordingly, the fair value of the plan is expensed over the vesting period.

On October 13, 2025, 70,000 warrants were granted and all were accepted.

The status of the 2025-2 warrant plan at December 31 is as follows:

---

| | | |
|:---|:---|:---|
| **Number of shares/warrants give right to for 2025-2 Plan** | **2025** | **2024** |
| Outstanding at January 1 |  |  |
| Granted | 70000 |  |
| Forfeited |  |  |
| Exercised |  |  |
| Expired |  |  |
| **Outstanding at December 31** | **70000** | **—** |
| **Exercisable at December 31** | **17500** | **—** |

---

In 2025, no warrants were exercised, forfeited or exercised. The remaining number of warrants as at December 31, 2025 equals 70,000 representing 70,000 shares.

**17.2. Accounting for equity-settled share-based payment**

The fair value of the plan is expensed over the vesting period. As a result of the exercise price reduction on March 24, 2023 of the warrants previously granted to warrant holders under the 2021 Warrants Plan, the Company determined the fair value of the options at the date of the modification (March 24, 2023). The incremental fair value of the re-priced warrants is recognised as an expense over the period from the modification date to the end of the vesting period. For the warrants already vested at the date of modification, the incremental fair value is fully recognised as an expense at date of modification.

The share-based compensation expense for all vested warrants recognized in the income statement was €4.9 million for the year ended December 31, 2025. For the year ended December 31, 2024 and the year ended December 31, 2023 the share-based compensation expense amounted respectively to €4.0 million and €2.6 million. The table below details the number of exercisable (vested) warrants and their weighted average exercised price. For presentation purposes the table reflect the number of shares the warrants give right to across all plans.

---

| | | |
|:---|:---|:---|
| **Total** | **2025** | **2024** |
| Exercisable warrants at December 31 | 1893182 | 1453726 |
| Shares representing the exercisable warrants at December 31 | 1893182 | 1453726 |
| Weighted average exercise price per share | 8.34 | 8.18 |
| Weighted average share price at the date of exercise | 6.56 | 9.24 |

---

[**Table of Contents**](#TOC)

**17.3. Fair value**

The fair value of each option or subscription right is estimated on the date of grant using the Black & Scholes model based on the following:

&nbsp;&nbsp;&nbsp;&nbsp;● The dividend return is estimated by reference to the historical dividend payment of the Group. Currently, this is estimated to be zero as no dividend have been paid since inception;

&nbsp;&nbsp;&nbsp;&nbsp;● Expected volatility is estimated based on a sample of similar companies based on the healthcare products sector of the Damodaran dataset;

&nbsp;&nbsp;&nbsp;&nbsp;● Risk-free interest rate is based on the yield of EUR bonds with an equivalent term to liquidation event;

&nbsp;&nbsp;&nbsp;&nbsp;● The expected life of the share options is based on current expectations and is not necessarily indicative of exercise patterns that may occur.

Fair value of the shares is estimated based on the market approach using publicly traded companies and acquisitions of private held companies within the same industry as Nyxoah. (Prior to the initial public offering)

The following table provides the input to the Black-Scholes model for warrants granted in 2020, 2021, 2022, 2023, 2024 and 2025 related to the 2020 warrant plan, the 2021 warrant plan, the 2022 warrant plan, the 2024 warrant plan, the 2025 warrant plan and the 2025-2 warrant plan. The table and notes uses as a basis, the number of shares the warrants give right to across all plans.

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
|  | <br>**2020 Plan**<br>**(grant 2020)** | **2021 Plan**<br>**(grant Sept 17** <br>**2021)** | **2021 Plan**<br>**(grant Oct 27** <br>**2021)** | **2021 Plan**<br>**(grant Feb 21** <br>**2022)** | **2021 Plan**<br>**(grant Feb 21** <br>**2022)** |
| Return dividend | 0% | 0% | 0% | 0% | 0% |
| Expected volatility | 56.32% | 51.30% | 51.50% | 49.80% | 49.80% |
| Risk-free interest rate | -0.20% | -0.36% | -0.18% | 0.37% | 0.37% |
| Expected life | 3 | 3 | 3 | 3 | 3 |
| Exercise price | 11.94 | 25.31 | 25.31 | 17.76 | 25.31 |
| Stock price | 10.20 | 25.75 | 20.50 | 17.50 | 17.50 |
| Fair value | 3.31 | 9.22 | 5.94 | 6.05 | 4.15 |

---

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
|  | **2021 Plan**<br>**(grant Feb 21** <br>**2022)** | **2021 Plan**<br>**(grant May 14** <br>**2022)** | **2021 Plan**<br>**(grant Jun 8** <br>**2022)** | **2021 Plan**<br>**(grant Aug 8** <br>**2022)** | **2021 Plan**<br>**(grant Aug 8** <br>**2022)** |
| Return dividend | 0% | 0% | 0% | 0% | 0% |
| Expected volatility | 49.80% | 49.80% | 52.60% | 53.71% | 53.97% |
| Risk-free interest rate | 0.50% | 1.06% | 1.60% | 1.39% | 1.45% |
| Expected life | 4 | 3 | 3 | 3 | 4 |
| Exercise price | 17.76 | 13.82 | 12.95 | 9.66 | 9.66 |
| Stock price | 17.50 | 13.82 | 13.34 | 9.75 | 9.75 |
| Fair value | 6.90 | 4.94 | 5.21 | 3.79 | 4.32 |

---

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
|  | **2021 Plan**<br>**(grant Mar 24** <br>**2023)** | **2021 Plan**<br>**(grant Apr 12** <br>**2023)** | **2021 Plan**<br>**(grant Jun 14** <br>**2023)** | **2022 Plan**<br>**(grant Jun 14** <br>**2023)** | **2022 Plan**<br>**(grant Oct 20** <br>**2023)** |
| Return dividend | 0% | 0% | 0% | 0% | 0% |
| Expected volatility | 52.00% | 52.00% | 51.28% | 51.28% | 50.00% |
| Risk-free interest rate | 3.20% | 3.24% | 3.36% | 3.36% | 3.55% |
| Expected life | 3 | 3 | 3 | 3 | 3 |
| Exercise price | 5.42 | 6.36 | 7.19 | 7.19 | 5.92 |
| Stock price | 6.70 | 7.08 | 7.10 | 7.10 | 5.60 |
| Fair value | 3.09 | 3.04 | 2.75 | 2.75 | 2.07 |

---

[**Table of Contents**](#TOC)

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
|  | **2022 Plan** <br>**(grant Feb 01** <br>**2024)** | **2022 Plan** <br>**(grant Apr 21** <br>**2024)** | **2022 Plan**<br>**(grant Aug 2**<br>**2024)** | **2024 Plan**<br>**(grant Aug 2**<br>**2024)** | **2024 Plan**<br>**(grant Sep 18** <br>**2024)** |
| Return dividend | 0% | 0% | 0% | 0% | 0% |
| Expected volatility | 62.20% | 65.50% | 66.00% | 66.00% | 65.20% |
| Risk-free interest rate | 2.63% | 3.08% | 2.55% | 2.55% | 2.38% |
| Expected life | 3 | 3 | 3 | 3 | 3 |
| Exercise price | 5.24 | 9.04 | 7.88 | 7.88 | 7.20 |
| Stock price | 9.96 | 9.20 | 7.56 | 7.56 | 7.54 |
| Fair value | 6.26 | 4.40 | 3.47 | 3.47 | 3.60 |

---

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
|  | **2024 Plan**<br>**(grant Nov 25** <br>**2024)** | **2024 Plan**<br>**(grant Nov 25** <br>**2024)** | **2024 Plan**<br>**(grant Feb 1** <br>**2025)** | **2024 Plan**<br>**(grant Feb 1** <br>**2025)** | **2025 Plan**<br>**(grant Feb 1** <br>**2025)** |
| Return dividend | 0% | 0% | 0% | 0% | 0% |
| Expected volatility | 63.70% | 63.70% | 63.00% | 63.00% | 63.00% |
| Risk-free interest rate | 2.24% | 2.24% | 2.26% | 2.26% | 2.26% |
| Expected life | 3 | 3 | 3 | 3 | 3 |
| Exercise price | 7.69 | 8.04 | 9.63 | 10.15 | 10.15 |
| Stock price | 8.10 | 8.10 | 10.15 | 10.15 | 10.15 |
| Fair value | 3.80 | 3.70 | 4.76 | 4.61 | 4.61 |

---

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
|  | **2025 Plan**<br>**(grant Mar 14**<br>**2025)** | **2025 Plan**<br>**(grant Apr 8**<br>**2025)** | **2025 Plan**<br>**(grant May 5**<br>**2025)** | **2024 Plan**<br>**(grant Sept 6**<br>**2025)** | **2025 Plan**<br>**(grant Sept 6**<br>**2025)** |
| Return dividend | 0% | 0% | 0% | 0% | 0% |
| Expected volatility | 63.00% | 65.24% | 64.97% | 64.90% | 64.90% |
| Risk-free interest rate | 2.40% | 2.11% | 2.02% | 2.16% | 2.16% |
| Expected life | 3 | 3 | 3 | 3 | 3 |
| Exercise price | 10.80 | 7.20 | 5.65 | 4.92 | 4.92 |
| Stock price | 10.80 | 5.76 | 5.65 | 4.92 | 4.92 |
| Fair value | 4.91 | 2.31 | 2.60 | 2.27 | 2.27 |

---

---

| | | |
|:---|:---|:---|
|  | **2025 Plan**<br>**(grant Oct 13**<br>**2025)** | **2025-2 Plan**<br>**(grant Oct 13**<br>**2025)** |
| Return dividend | 0% | 0% |
| Expected volatility | 65.53% | 65.53% |
| Risk-free interest rate | 2.18% | 2.18% |
| Expected life | 3 | 3 |
| Exercise price | 5.56 | 5.56 |
| Stock price | 5.56 | 5.56 |
| Fair value | 2.59 | 2.59 |

---

[**Table of Contents**](#TOC)

As a result of the exercise price reduction on March 24, 2023 of the warrants previously granted to warrant holders under the 2021 Warrants Plan, the Company determined the fair value of the options at the date of the modification (March 24, 2023). The fair value of the modified warrants was determined using the same models and principles as described above, with the following model inputs:

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **2021 Plan**<br>**(grant Sept 17** <br>**2021)** | **2021 Plan**<br>**(grant Oct 27**<br>**2021)** | **2021 Plan**<br>**(grant Feb 21**<br>**2022)** | **2021 Plan**<br>**(grant Feb 21**<br>**2022)** |
| Return dividend | 0% | 0% | 0% | 0% |
| Expected volatility | 52.00% | 52.00% | 52.00% | 52.00% |
| Risk-free interest rate | 3.25% | 3.25% | 3.17% | 3.36% |
| Expected life | 2 | 2 | 2 | 2 |
| Exercise price | 5.42 | 5.42 | 5.42 | 5.42 |
| Stock price | 6.68 | 6.68 | 6.68 | 6.68 |
| Fair value | 2.00 | 3.00 | 3.00 | 2.00 |
| Incremental fair value | 2.38 | 2.40 | 2.23 | 2.38 |

---

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **2021 Plan**<br>**(grant Feb 21**<br>**2022)** | **2021 Plan**<br>**(grant May 14**<br>**2022)** | **2021 Plan**<br>**(grant Aug 8**<br>**2022)** | **2021 Plan**<br>**(grant Aug 8**<br>**2022)** |
| Return dividend | 0% | 0% | 0% | 0% |
| Expected volatility | 52.00% | 52.00% | 52.00% | 52.00% |
| Risk-free interest rate | 3.03% | 3.13% | 3.13% | 2.98% |
| Expected life | 3 | 2 | 3 | 4 |
| Exercise price | 5.42 | 5.42 | 5.42 | 5.42 |
| Stock price | 6.68 | 6.68 | 6.68 | 6.68 |
| Fair value | 3.05 | 2.75 | 2.87 | 3.21 |
| Incremental fair value | 2.23 | 1.92 | 1.28 | 1.19 |

---

The weighted average fair value of warrants granted during the year was €3.47 in 2025 and €6.09 in 2024. The weighted average remaining contractual life for the share options outstanding as at December 31 was 6.26 in 2025 and 5.4 in 2024.

**1.4 Equity-settled share-based payment transactions – Restricted Stock Units ("RSU")**

In 2024 and 2025, each non-executive director was granted "restricted share units" or "RSUs", whereby each RSU represents the obligation of the relevant non-executive director to subscribe for one new ordinary share of the Company at a subscription price of EUR 0.1718 per share (irrespective of the market value of the share at that time).

The key features of the RSUs can be summarized as follows:

&nbsp;&nbsp;&nbsp;&nbsp;● Unless the shareholders' meeting of the Company decides otherwise, whether for one, more or all non-executive directors, RSUs will be granted to non-executive directors on a yearly basis on the date of the annual shareholders' meeting.

&nbsp;&nbsp;&nbsp;&nbsp;● RSUs do not grant voting rights, preferential subscription rights or other membership rights.

&nbsp;&nbsp;&nbsp;&nbsp;● The number of RSUs to be granted on an annual basis shall be calculated as follows: EUR 130,000 divided by the average closing price of the Company's shares on the stock exchange where the Company's shares are first listed, during the month of May of the year of the grant. For directors that are appointed between two annual shareholders' meetings, this number shall be prorated.

&nbsp;&nbsp;&nbsp;&nbsp;● RSUs are not transferable, except in case of death.

&nbsp;&nbsp;&nbsp;&nbsp;● RSUs in principle vest on the first anniversary of the date of grant provided that the relevant non-executive director is still in office at that time. In the event of death or an "exit", immediate vesting applies.

&nbsp;&nbsp;&nbsp;&nbsp;● The vesting of RSUs is not linked to any performance criteria but rather based on continued service during the vesting period. Therefore, the remuneration in RSUs is a form of fixed remuneration.

[**Table of Contents**](#TOC)

&nbsp;&nbsp;&nbsp;&nbsp;● The grant of RSUs to a non-executive director that has not been explicitly refused by the relevant non-executive director fifteen calendar days following the date of grant, shall be deemed accepted by the relevant non-executive director and creates an obligation for the relevant non-executive director to subscribe for the underlying shares when the RSUs have vested. The RSU is therefore not an option leaving discretion with the director whether to exercise or not.

&nbsp;&nbsp;&nbsp;&nbsp;● The new shares to be issued pursuant to the exercise of RSUs shall be issued, subscribed, and fully paid up in principle within one month following the date of vesting of the relevant RSUs. The new shares shall be issued under the authorized capital of the Company. The Company reserves the right to deliver existing shares (if it has access to its own shares in accordance with applicable company law rules) or to compensate non-executive directors in cash (i.e., a cash amount equal to the closing stock price of the shares on the stock exchange where the Company's shares are first listed on the first trading day following the date of vesting of the relevant RSUs, minus the subscription price of EUR 0.1718 per share).

The RSUs will be accounted for as an equity-settled share-based payment plan as the Company can issue new shares under the authorized capital.

At June 12, 2024, the Company has granted a total of 103,642 RSUs towards 7 directors which vested at the shareholders' meeting held in June 2025. The fair value of the RSUs granted is equal to the share price at the grant date minus the exercise price of EUR 0.1718 and equals EUR 7,65 per RSU granted. As at December 31, 2025 all RSUs had been exercised and the related shares were issued. The weighted average exercise price of the RSU's exercised is 0.1718. The weighted average share price at the date of exercise was 6.77.

At June 11, 2025, the Company has granted a total of 146,531 RSUs, with the same conditions as the 2024 RSUs, towards 7 directors which will vest at the shareholders' meeting held in June 2026. The fair value of the RSUs granted is equal to the share price at the grant date minus the exercise price of EUR 0.1718 and equals EUR 6,66 per RSU granted The total RSUs outstanding as at December 31, 2025 was 146,531 RSUs. The weighted average exercise price of the RSU's granted is 0.1718.

**18.**Financial debt

Financial debt mainly consists of recoverable cash advances, EIB finance agreement and synthetic warrants and convertible bond instrument. The related amounts as at December 31, 2025 and 2024, can be summarized as follows:

---

| | | |
|:---|:---|:---|
|  | **As at December 31** | **As at December 31** |
| (in EUR 000) | **2025** | **2024** |
| Recoverable cash advances - Non-current | 8276 | 8623 |
| Recoverable cash advances - Current | 333 | 248 |
| **Total recoverable cash advances** | **8609** | **8871** |
| Loan facility agreement - Non-current | 7793 | 6898 |
| Synthetic warrants - Non-current | 1601 | 3204 |
| **Total EIB** | **9394** | **10102** |
| Convertible bond - Current | 22657 |  |
| **Total convertible bond** | **22657** | **—** |
| **Total financial debt** | **40660** | **18973** |
| Non-current | 17670 | 18725 |
| Current | 22990 | 248 |

---

[**Table of Contents**](#TOC)

**18.1. Financial debt related to recoverable cash advances**

***Recoverable cash advances received***

As at December 31, 2025, the details of recoverable cash advances received can be summarized as follows:

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **Contractual** | **Advances** | **Fixed** | **Variable** |
| (in EUR 000) | **advances** | **received** | **reimbursements\*** | **reimbursements\*** |
| Sleep apnea device (6472) | 1600 | 1600 | 588 | 8 |
| First articles (6839) | 2160 | 2160 | 669 | 24 |
| Clinical trial (6840) | 2400 | 2400 | 585 | 28 |
| Activation chip improvements (7388) | 1467 | 1467 | 117 | 38 |
| **Total** | **7627** | **7627** | **1959** | **98** |

---

\* Excluding interests

&nbsp;&nbsp;&nbsp;&nbsp;● The Convention 6472 "Sleep apnea device" for a total amount of € 1.6 million was signed in 2011. The total amount of the advance has been received before January 1, 2015. The Company has notified his intention to exploit the results of this project before 2015. At December 31, 2025, the Company repaid all fixed reimbursements amounting to € 0.6 million (excluding interests). The turnover dependent reimbursement is based on 0.224% of the sales achieved by June 2037. The Company made no variable reimbursement in the year ended December 31, 2025 (2024: €1,000).

&nbsp;&nbsp;&nbsp;&nbsp;● The Convention 6839 "First Articles" for a total amount of €2.2 million was signed on December 5, 2012. As at December 31, 2025, the advance received amounted to €2.2 million. The turnover dependent reimbursement is based on 0.3% of the sales achieved by June 2037. The Company notified to the Region its decision about the exploitation of the results during 2017, therefore fixed reimbursement started in 2018. As at December 31, 2025, cumulated fixed reimbursements amount to €0.7 million (excluding interests) out of which €40,000 was reimbursed in 2025 and €67,000 in 2024. The Company made no variable reimbursement in the year ended December 31, 2025 (2024: €13,000).

&nbsp;&nbsp;&nbsp;&nbsp;● The Convention 6840 "Clinical Trial" for a total amount of €2.4 million was signed on December 6, 2012. As at December 31, 2025, the advance received amounted to €2.4 million. The turnover dependent reimbursement is based on 0.336% of the sales achieved by June 2037. The Company has notified to the Region its decision about the exploitation of the results in the course of 2018. As at December 31, 2025, cumulated fixed reimbursements amount to €0.6 million (excluding interests) out of which €75,000 was reimbursed in 2025 and €150,000 in 2024. The Company made a reimbursement of a variable part amounting to €15,000 in the year ended December 31, 2025 (2024: € 0).

&nbsp;&nbsp;&nbsp;&nbsp;● The Convention 7388 "Implant for Obstructive Sleep Apnea, "Activation Chip Improvements" for a total amount of €1.5 million was signed in December 2015. As at December 31, 2025, the advance received amounted to €1.5 million. The turnover dependent reimbursement is based on 0.450% of the sales achieved to June 2039. In 2019, the Company has notified to the Region its decision about the exploitation of the results. As at December 31, 2025, cumulated fixed reimbursements amount to €117,000 (excluding interests) out of which €29,000 was reimbursed in 2025 and €22,000 in 2024. The Company made a reimbursement of a variable part amounting to €20,000 in the year ended December 31, 2025 (2024: € 0).

***Evolution of the financial debt in the financial statements***

The determination of the amount to be reimbursed to the Walloon Region under the signed agreements is subject to a degree of uncertainty as it depends on the amount of the future sales that the Company will generate or not in the future. To determine the fair value of those advances, management of the Company has considered the possible outcomes of the program currently benefiting from the support of the Walloon Region. Management has considered that the probability to have to reimburse the 30% non-revocable repayment has a probability of 100% to occur. The reimbursement of the variable part, the fair value of which is determined on the basis of the sales forecasts largely depends on external factors such as CE marking, social security programs, post-market studies and expected timing and level of sales.

Management performed an initial recognition of the financial debt for the variable part using a discount rate of 12.5%.

[**Table of Contents**](#TOC)

The table below details the remaining undiscounted cash flows resulting from the reimbursement of the recoverable cash advances. The initial recognition of the liability reflects a reimbursement up to 2 times the amount of cash advance received, with the exception of Convention 6840 where the due date of the variable reimbursements (June 2029) occurs before the maximum of 2 times the amount of cash advance received is reached.

---

| | | |
|:---|:---|:---|
|  | **As at December 31** | **As at December 31** |
| (in EUR 000) | **2025** | **2024** |
| Recoverable cash advances received | 7627 | 7627 |
| Amounts to be reimbursed | 15254 | 15254 |
| Amounts reimbursed at year-end (interests included) | (2320) | (2122) |
| **Total recoverable cash advances (undiscounted)** | **12934** | **13132** |

---

Based on expected timing of sales and after discounting, the financial debt related to the recoverable cash advances is as follows:

---

| | | |
|:---|:---|:---|
|  | **As at December 31** | **As at December 31** |
| (in EUR 000) | **2025** | **2024** |
| Contract 6472 | 1697 | 1711 |
| Contract 6839 | 2229 | 2332 |
| Contract 6840 | 2650 | 2819 |
| Contract 7388 | 2033 | 2009 |
| **Total recoverable cash advances** | **8609** | **8871** |
| Non-current | 8276 | 8623 |
| Current | 333 | 248 |
| **Total recoverable cash advances** | **8609** | **8871** |

---

The amounts recorded under "Current" caption correspond to the sales-independent amounts (fixed repayment) and sales-dependent reimbursements (variable repayment) estimated to be repaid to the Walloon Region in the next 12-month period. The estimated sales-independent (fixed repayment) as well as sales-dependent reimbursements (variable repayment) beyond 12-months are recorded under "Non-current" liabilities. Changes in the recoverable cash advances can be summarized as follows:

---

| | | |
|:---|:---|:---|
| (in EUR 000) | **2025** | **2024** |
| As at January 1 | 8871 | 8674 |
| Advances reimbursed (excluding interests) | (179) | (254) |
| Interests paid | (20) | (26) |
| Initial measurement and re-measurement | (1142) | (561) |
| Discounting impact | 1079 | 1038 |
| **As at December 31** | **8609** | **8871** |

---

The discounting impact is included and presented in the financial expenses and amounted to €1.1 million (2024: €1.0 million). The initial measurement and re-measurement are included in other operating income and amounted to €1.1 million for the year ended December 31, 2025 (2024: €0.6 million).

A sensitivity analysis of the carrying amount of recoverable cash advances has been done to assess the impact of a change in assumptions. The Company tested reasonable sensitivity to changes in revenue projections of +/- 25% and in the discount rates of +/- 25%. The table hereunder details the sensitivity results:

---

| | | | |
|:---|:---|:---|:---|
| **Fair value of liabilities as of end of 2025 (in EUR 000)** | **Variation of revenue projections** | **Variation of revenue projections** | **Variation of revenue projections** |
| Variation of discount rates \* | -25% | 0% | 25% |
| -25% | 9035 | 9457 | 9735 |
| 0% | 8126 | 8609 | 8933 |
| 25% | 7352 | 7872 | 8230 |

---

\* A change of -25% in the discount rates implies that the discount rate used for the fixed part of the recoverable cash advances is 3,8 % instead of 5 % while the one used for the variable part is 9.4 % instead of 12.5%.

[**Table of Contents**](#TOC)

An increase of 25% of revenue projections implies, if discount rates does not change, an increase of the expected liability as repayment of the liability is accelerated.

An increase of 25% of the discount rate decreases the expected liability if revenue projections remain unchanged.

**18.2. Financial debt related to loan facility agreement and synthetic warrants agreement**

On July 3, 2024 the Company has signed a €37.5 million loan facility agreement with the European Investment Bank ("EIB"). The agreement is backed by the European Commission's InvestEU program. The Company plans to use the funding for research and development, and for scaling-up its manufacturing capacity to meet demand outside the U.S. and in the U.S. The €37.5 million facility is divided into three tranches: €10 million for the first tranche ("Tranche A"), €13.75 million for the second tranche ("Tranche B") and €13.75 million for the third tranche ("Tranche C"). Disbursement under the various tranches is subject to certain conditions. Tranche A carries an annual 5% cash and 5% capitalized interest rate, and features a five-year bullet repayment schedule. The various tranches do not contain revenue or liquidity covenants.

The first tranche A for an amount of €10 million, was disbursed on July 26, 2024.

On December 16, 2025, there has been a signed amendment letter to the loan facility agreement between the Company and the EIB. The EIB amendment is the result of the Bond Subscription Agreement which qualifies as a notified event in the EIB finance contract. The payment obligations arising from the Bond Subscription Agreement rank subordinate to the EIB loan. In case any amount under the Bond Subscription Agreement is likely to be paid in cash by the Company, the Company shall promptly prepay the EIB loan outstanding (principal amounts) for the same amount, before any cash payment is made under the Bond Subscription Agreement. There is no expected change in the estimated future cash payments of the EIB loan due to a remote possibility of cash reimbursements under the Bond Subscription Agreement. Refer to note 18.3.

In connection with the loan facility agreement, and as a condition to drawdown thereunder, the Company also entered into a "synthetic warrant agreement" with the EIB. Under the synthetic warrant agreement, in consideration for the facility, in connection with each tranche of the facility, the EIB will be granted "synthetic warrants" with a duration of 20 years. The number and strike price of the synthetic warrants will be calculated based on tranche specific formulas provided for in the synthetic warrant agreement. The synthetic warrants can be exercised as of the maturity date of the relevant tranche of the facility or, in exceptional situations, earlier. Such synthetic warrants will entitle the EIB to receive from the Company a cash consideration equal to the 20-day volume weighted average price of a share in the Company on the stock exchange, reduced by the applicable strike price per synthetic warrant, and multiplied by the number of synthetic warrants that the EIB exercises. In connection with Tranche A, the EIB has been granted 468,384 synthetic warrants with a strike price of €8,54 that the EIB can exercise after the maturity of Tranche A (5 years) or, in exceptional situations, earlier.

The finance agreement with the EIB also includes a prepayment option derivative. We refer to note 4.4 and 10.

Change in loan facility can be summarized as follows:

---

| | | |
|:---|:---|:---|
| (in EUR 000) | **2025** | **2024** |
| **As at January 1** | **6898** | **—** |
| New debt |  | 10000 |
| Transaction cost related to loans and borrowings |  | (175) |
| Separation of non-closely related embedded derivates |  | (3042) |
| Capitalized interest | 500 |  |
| Effective interest rate adjustment | 395 | 115 |
| **As at December 31** | **7793** | **6898** |

---

[**Table of Contents**](#TOC)

Change in synthetic warrants can be summarized as follows:

---

| | | |
|:---|:---|:---|
| (in EUR 000) | **2025** | **2024** |
| **As at January 1** | **3204** | **—** |
| Separation of non-closely related embedded derivates |  | 3169 |
| Fair value adjustment | (1603) | 35 |
| **As at December 31** | **1601** | **3204** |

---

Change in prepayment option can be summarized as follows:

---

| | | |
|:---|:---|:---|
| (in EUR 000) | **2025** | **2024** |
| **As at January 1** | **(112)** | **—** |
| Separation of non-closely related embedded derivates |  | (127) |
| Fair value adjustment | 21 | 15 |
| **As at December 31** | **(91)** | **(112)** |

---

&nbsp;&nbsp;&nbsp;&nbsp;**18.3.** **Financial debt related to C onvertible Bond Instrument** 

On November 13, 2025, the Company entered into a bond subscription agreement with an international financial services firm for the issuance of a Convertible Bond Instrument for an aggregate maximum principal amount of up to €45 million. The financing consists of a first tranche of 225 Convertible Bond Instruments up to €22.5 million with an option to issue a second tranche of another 225 Convertible Bond Instruments of up to €22.5 million at the Company's discretion, within the period commencing 7 months following the first tranche closing date to (but excluding) the date falling one month thereafter. The closing for the first tranche of the Convertible Bond Instruments occurred on December 18, 2025 and will mature on November 18, 2028 ("First Tranche"). The First Tranche carry an interest rate of 6.5 per cent per annum, payable every quarter in arrears. The initial principal amount per Bond Instruments amounts to €100.000. The Bond Instruments have a three-year maturity from issuance with quarterly amortization payments of principal and interest (per 18 February, 18 May, 18 August and 18 November of each year). On each instalment date, the principal instalment per Bond Instrument will be €8.500 except for the last instalment which will be €6.500 per bond. The initial conversion price for the first tranche of bonds, which can be modified, shall be equal to €5.00.

The bond instrument has a number of conversion features and settlement options which are summarized below:

&nbsp;&nbsp;&nbsp;&nbsp;● At any time, the bondholder can convert the whole of the then outstanding principal amount of the bond into new shares ("Bond conversion right") at an initial conversion price of €5 (which can be modified);

&nbsp;&nbsp;&nbsp;&nbsp;● At any time, the bondholder has the option to defer any or more instalments to a subsequent instalment date specified in the required notice (at least 1 day before the scheduled instalment date) ("Deferred amortized payment");

&nbsp;&nbsp;&nbsp;&nbsp;● At any time, the bondholder has the option to advance up to 2 instalments (specifically the last 2 instalments of the amortization period) by giving notice at any time during the regular amortisation period ("Advanced amortized payment").

&nbsp;&nbsp;&nbsp;&nbsp;● At each instalment date, the Company has the option to convert the principal instalment amount and accrued interest into shares at a conversion price which is the lowest of 90% of the share price at instalment date and the initial conversion price of €5 (which can be modified) ("Share settlement option");

&nbsp;&nbsp;&nbsp;&nbsp;● At each instalment date, when the Company decides not to convert the principal instalment amount and accrued interest into shares but pay in cash, the bondholder has the right to convert the principal instalment amount at the initial conversion price of €5 (which can be modified) ("Amortisation conversion right");

&nbsp;&nbsp;&nbsp;&nbsp;● At each instalment date, and when the Share settlement option or the Amortisation conversion right are not exercised, the Company will need to pay in cash the principal instalment amount and accrued interest at an amount which is the sum of the accrued interest and 103% of the principal instalment amount;

[**Table of Contents**](#TOC)

On December 16, 2025, there has been a signed amendment letter to the loan facility agreement between the Company and the EIB (see above). Refer to note 18.2. In case any amount under the Bond Subscription Agreement is likely to be paid by the Company, the Company shall promptly prepay the EIB loan outstanding (principal amounts) for the same amount, before any cash payment is made under the Bond Subscription Agreement.

The Bond Instrument is accounted for as a hybrid financial instrument containing a host financial liability with embedded derivatives that are closely related (Deferred amortized payment) and embedded derivatives that are not closely related (Bond conversion right, Amortization conversion right, Share settlement option and Advanced amortized payment). The entire hybrid contract is designated by management at fair value through profit and loss. The fair value of the hybrid contract is estimated using a Longstaff–Schwartz Monte Carlo approach, in which share prices are simulated forward on a weekly basis over a 36-month horizon, with each instalment date treated as a decision point. At maturity, the model computes the terminal payoff, after which the valuation is performed by working backwards through time: at each decision point, the continuation value (i.e., the expected value of waiting rather than exercising) is obtained by discounting the value from the next decision point and is then estimated via regression on the simulated state variables. The model compares the immediate exercise value with the regression-based expected continuation value to determine the optimal exercising strategy, assuming exercise occurs whenever the value of exercising now exceeds the expected value of waiting, and the resulting optimal exercise strategy is used to derive the Bond Instruments' fair value.

The valuation model is dependent on the following significant inputs:

---

| | | |
|:---|:---|:---|
|  | **Per Dec 18, 2025** | **Per Dec 31, 2025** |
| Coupon (interest) rate | 6.5% | 6.5% |
| Conversion price | 5.00 | 5.00 |
| Stock price | 4.05 | 4.09 |
| Return dividend | 0.0% | 0.0% |
| Expected volatility | 65.34% | 65.18% |
| Discount rate | 10.24% | 10.23% |

---

The expected volatility has been estimated based on the historical share prices of the Company on Euronext (as this is the primary stock exchange as determined in the Bond Subscription Agreement). The risk-free interest rate is based on the 3-month Euribor rate. The discount rate is determined based on risk-free interest rate plus an credit spread estimated for the Company based on the previous debt instruments and factors such as financial results, liquidity needs that may impact the credit spread of the Company.

The transaction price of the Bond Instrument at initial recognition is the consideration of the first tranche for €22.5 million. The difference between the transaction price and the fair value at initial recognition is considered a 'day 1' loss, amounting to €8.7 million, which is recognized in profit and loss on a systematic straight line basis throughout the term of the Bond Instrument. Transaction costs are recognized in financial expenses in the consolidated income statement. Refer to note **22**.

Change in the convertible bond can be summarized as follows:

---

| | |
|:---|:---|
|  | **As at December 31** |
| (in EUR 000) | **2025** |
| Initial fair value | 31192 |
| Fair value adjustment | 51 |
| **Total fair value** | **31243** |
| Day 1 loss | (8692) |
| Amortization | 106 |
| **Total day 1 loss** | **(8586)** |
| **Total convertible bond** | **22657** |

---

[**Table of Contents**](#TOC)

**19.**Provisions

---

| | | |
|:---|:---|:---|
|  | **As at December 31** | **As at December 31** |
| (in EUR 000) | **2025** | **2024** |
| Provision for constructive obligation | 1206 | 672 |
| Other provisions | 190 | 328 |
| **Total provisions** | **1396** | **1000** |

---

As at December 31, 2025, the Company has a constructive obligation related to the ongoing replenishment of certain consumable components, based on business practices and customer expectations.

On May 30, 2025, the Company was sued in the U.S. District Court of Delaware by Inspire Medical, Inc. ("Inspire") for the alleged infringement of 3 Inspire patents (US Patent Nos: 10,898,709, 11,806,526, and 11,850,424). The complaint requests customary remedies for patent infringement, including (i) a judgment that the Company has infringed and is infringing the Inspire Patents, (ii) damages, (iii) attorneys' fees, (iv) a permanent injunction preventing the Company from infringing the Inspire Patents and (v) costs and expenses. The Company subsequently engaged counsel to represent the Company in this case. The Company intends to vigorously defend itself against the allegations brought forward in the Inspire complaint.

On September 15, 2025, the Company has filed a lawsuit against Inspire in the U.S. District Court of Delaware for the alleged infringement of 3 Nyxoah patents (US Patent Nos: 8,700,183, 9,415,215, and 9,415,216). The complaint requests customary remedies for patent infringement, including (i) a judgment that Inspire has infringed and is infringing the Nyxoah Patents, (ii) damages, (iii) attorneys' fees, (iv) a permanent injunction preventing Inspire from infringing the Company's patents and (v) costs and expenses.

Given the early stage of this litigation, the Company is unable to predict the likelihood of success of the Inspire claims against the Company or to quantify any risk of loss. Therefore, the Company has not accrued for any potential litigation losses as of December 31, 2025. Legal costs incurred in connection with this matter have been accrued through December 31, 2025, and are recognized in the Research and Development Expense on the line item "Consulting and contractors fees". The Company will review the status of the litigation each quarter going forward for accrual purposes.

**20.**Trade payables

---

| | | |
|:---|:---|:---|
|  | **As at December 31** | **As at December 31** |
| (in EUR 000) | **2025** | **2024** |
| Payables | 5168 | 3749 |
| Invoices to be received | 8559 | 5756 |
| **Total trade payables** | **13727** | **9505** |

---

**The increase in total trade payables of €4.2 million as at December 31, 2025 is due to an increase in payables of €1.4 million and an increase in invoices to be received of €2.8 million. The increase reflects higher business activity.**

The Company normally settles its trade payables in 30 days.

**21.**Other liabilities

---

| | | |
|:---|:---|:---|
|  | **As at December 31** | **As at December 31** |
| (in EUR 000) | **2025** | **2024** |
| Holiday pay accrual | 552 | 903 |
| Salary | 3840 | 3354 |
| Accrued expenses | 482 | 511 |
| Foreign currency swaps and forwards - current |  | 353 |
| VAT payable | 246 |  |
| Other | 1509 | 1103 |
| **Total other liabilities** | **6629** | **6224** |

---

The increase of €405,000 in other liabilities as at December 31, 2025, compared to December 31, 2024, is mainly due to an increase in other, in salaries and in VAT payable, partially offset by a decrease in the holiday pay accrual and in the fair value of the foreign currency swaps and forwards. We refer to note 21.1 for more details on the foreign currency swaps and forwards.

[**Table of Contents**](#TOC)

As at December 31, 2025 and as at December 31, 2024, Other mainly consists of an outstanding liability related to the continued development of the Company's strategic R&D project

**21.1. Foreign currency swaps and forwards**

The Company is exposed to currency risk primarily due to the expected future USD, AUD and NIS expenses that will be incurred as part of the ongoing and planned marketing, clinical trials and other related expenses. A financial risk management policy has been approved to i) generate yields on liquidity and ii) reduce the exposure to currency fluctuations with a timeline up to 24 months and by means of foreign currency swaps and forwards. There have not been any transfers of level 3 categories during the year.

The Company has entered into several foreign currency swaps and forwards for which the notional amounts are detailed in the table below:

---

| | | |
|:---|:---|:---|
|  | **As at December 31** | **As at December 31** |
| (in EUR 000) | **2025** | **2024** |
| Foreign currency swaps EUR - USD (in EUR) |  | 5000 |
| Foreign currency swaps EUR - USD (in USD) |  | 5451 |
| Foreign currency forwards EUR - USD (in EUR) | 2000 | 4000 |
| Foreign currency forwards EUR - USD (in USD) | 2355 | 4277 |

---

The following table shows the carrying amount of these derivative financial instruments measured at fair value in the statement of the financial position including their levels in the fair value hierarchy:

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **As at December 31, 2025** | **As at December 31, 2025** | **As at December 31, 2025** | **As at December 31, 2025** |
| (in EUR 000) | **Level I** | **Level II** | **Level III** | **Total** |
| *Financial assets* |  |  |  |  |
| Foreign currency forwards |  | 4 |  | 4 |

---

The fair value is determined by the financial institution and is based on foreign currency swaps and forwards rates and the maturity of the instrument. All foreign currency swaps and forwards are classified as current as their maturity date is within the next twelve months.

The change in the balance of the financial asset is detailed as follows:

---

| | | |
|:---|:---|:---|
| (in EUR 000) | **2025** | **2024** |
| **Opening value at January 1** | **—** | **343** |
| Settled contracts |  | (343) |
| Fair value adjustments | 4 |  |
| **Closing value at December 31** | **4** | **—** |

---

The change in the balance of the financial liability is detailed as follows:

---

| | | |
|:---|:---|:---|
| (in EUR 000) | **2025** | **2024** |
| **Opening value at January 1** | **353** | **90** |
| Fair value adjustments |  | 353 |
| Settled contracts | (353) | (90) |
| **Closing value at December 31** | **—** | **353** |

---

[**Table of Contents**](#TOC)

**22.**Revenue and cost of goods sold

For the year ended December 31, 2025, the Company generated revenue for the amount of €10.0 million compared to €4.5 million for the year ended December 31, 2024 and €4.3 million for the year ended December 31, 2023.

Revenue is recognized based on the satisfaction of performance obligations identified in customer contracts. Performance obligations are satisfied when control of the Genio system is transferred to the customer, either upon shipment or delivery, depending on contractual terms. The revenue related to the first performance obligation (i.e. shipment or delivery of the Genio system implants) is recognized at a point in time. Due to the start of the commercialization in the United States, certain patient-related components are supplied after the initial shipment. In this case, a portion of the transaction price is allocated to this future delivery, with revenue deferred and recognized at a point in time upon delivery. Moreover, as from 2024, the Company has identified a separate performance obligation related to the replenishment of additional disposable patches beyond the initial shipment. A portion of the transaction price is allocated to these future deliveries, with revenue deferred and recognized over time upon transfer of control.

The contract liability included in the consolidated balance sheet is related to revenue attributed to the additional replenishment of disposable patches which is recognized when control of the patches is transferred to the customer or patient quarterly following the patient implants and the revenue attributed to the future deliveries of the patient-related components in the United States. Per December 31, 2025, the current contract liability amounts to €0.9 million while the non-current contract liability amounts to €0.7 million. Per December 31, 2024, the current contract liability amounts to €117,000 while the non-current contract liability amounts to €472,000.

The sales based on country of customer for the year ended December 31, 2025, 2024 and 2023:

---

| | | | |
|:---|:---|:---|:---|
|  | **For the year ended December 31** | **For the year ended December 31** | **For the year ended December 31** |
| (in EUR 000) | **2025** | **2024** | **2023** |
| Sales Germany | 4488 | 3593 | 3816 |
| Sales Spain | 14 | 64 | 37 |
| Sales Switzerland | 313 | 675 | 373 |
| Sales Austria | 17 | 53 | 122 |
| Sales Netherlands | 131 |  |  |
| Sales UAE | 563 |  |  |
| Sales Italy | 28 | 40 |  |
| Sales England | 816 | 96 |  |
| Sales US | 3650 |  |  |
| **Total sales** | **10020** | **4521** | **4348** |

---

For the year ended December 31, 2025, the Company has no customer with sales larger than 10% of total. (2024: one customers with individual sales larger than 10% of the total revenue and this client contributed to the turnover for an amount of €0,9 million and 2023: one customer with contribution to the turnover of €424,000).

Cost of goods sold for the year ended December 31, 2025, 2024 and 2023:

---

| | | | |
|:---|:---|:---|:---|
|  | **For the year ended December 31** | **For the year ended December 31** | **For the year ended December 31** |
| (in EUR 000) | **2025** | **2024** | **2023** |
| Purchases of goods and services (\*) | 3638 | 2953 | 4089 |
| Inventory movement | 56 | (1401) | (2433) |
| **Total cost of goods sold** | **3694** | **1552** | **1656** |

---

(\*) Including purchases of raw material, direct labour allocation, indirect labour allocation, fees of subcontractors, warranty and shipping cost (direct)

[**Table of Contents**](#TOC)

**23.** **Operating expenses**

The tables below detail the operating expenses for the year ended December 31, 2025, 2024 and 2023:

---

| | | | |
|:---|:---|:---|:---|
|  |  |  | **Operating** |
|  |  |  | **expense for the** |
| (in EUR 000) | **Total cost** | **Capitalized** | **year** |
| Research and development | 45788 | (2964) | 42824 |
| Selling, general and administrative expenses | 48261 |  | 48261 |
| Other income and expenses | (1373) | 99 | (1274) |
| **For the year ended December 31, 2025** | **92676** | **(2865)** | **89811** |

---

---

| | | | |
|:---|:---|:---|:---|
|  |  |  | **Operating**  |
|  |  |  | **expense for the** |
| (in EUR 000) | **Total cost** | **Capitalized** | **year** |
| Research and development | 39234 | (4909) | 34325 |
| Selling, general and administrative expenses | 28461 |  | 28461 |
| Other income and expenses | (1091) | 83 | (1008) |
| **For the year ended December 31, 2024** | **66604** | **(4826)** | **61778** |

---

---

| | | | |
|:---|:---|:---|:---|
|  |  |  | **Operating**  |
|  |  |  | **expense for the**  |
| (in EUR 000) | **Total cost** | **Capitalized** | **year** |
| Research and development | 35125 | (8474) | 26651 |
| Selling, general and administrative expenses | 21687 |  | 21687 |
| Other income and expenses | (1549) | 1005 | (544) |
| **For the year ended December 31, 2023** | **55263** | **(7469)** | **47794** |

---

**24.** **Research and development expenses**

Research and development expenses consist primarily of product development, engineering to develop and support our products, testing, consulting services and other costs associated with the next generation of the Genio system. These expenses primarily include employee compensation, consulting and contractor's fees and outsourced development expenses.

---

| | | | |
|:---|:---|:---|:---|
|  | **For the year ended December 31** | **For the year ended December 31** | **For the year ended December 31** |
| (in EUR 000) | **2025** | **2024** | **2023** |
| Staff costs | 14556 | 13118 | 13803 |
| Consulting and contractors' fees | 10001 | 6458 | 2762 |
| Q&A regulatory | 236 | 354 | 263 |
| Depreciation and amortization expense | 3161 | 1428 | 1314 |
| Impairment loss on (in)tangible assets | 1178 |  |  |
| Travel | 1295 | 1282 | 1179 |
| Manufacturing and outsourced development | 8083 | 8586 | 6458 |
| Clinical studies | 4979 | 6102 | 4929 |
| Other expenses | 996 | 1072 | 1674 |
| Training | 1059 | 153 |  |
| IP costs |  | 44 | 941 |
| IT | 244 | 637 | 1802 |
| Capitalized costs | (2964) | (4909) | (8474) |
| **Total research and development expenses** | **42824** | **34325** | **26651** |

---

[**Table of Contents**](#TOC)

Before capitalization of €3.0 million for the year ended December 31, 2025 and €4.9 million for the year ended December 31, 2024, research and development expenses increased by €6.6 million or 16.7 % from €39.2 million for the year ended December 31, 2024, to €45.8 million for the year ended December 31, 2025. The increase is the result of higher R&D activities mainly reflected in the 'Consulting and contractors' fees' line and training activities, mainly offset by a decrease in clinical study expenses. Additionally, following FDA approval in August 2025, the amortization of the related intangible assets commenced leading to an increase in depreciation and amortization expenses.

During the year ended as at December 31, 2025, the Company recognized an impairment loss on (in)tangible assets of € 1.2 million. For more information, we refer to note 7 and 8.

In May 2025, the Company became involved in an intellectual property litigation in the United States. For more information, we refer to note 19.

Before capitalization of €4.9 million for the year ended December 31, 2024 and €8.5 million for the year ended December 31, 2023, research and development expenses increased by €4.1 million or 11.7% from €35.1 million for the year ended December 31, 2023, to € 39.2 million for the year ended December 31, 2024. This increase was primarily driven by higher R&D activities and clinical expenses, mainly reflected in the 'Consulting and contractors' fees' line, along with an overall rise in manufacturing and outsourced development costs, which includes a €1.9 million cost to further develop our strategic R&D projects. These impacts were partially offset by lower manufacturing expenses due to higher inventory value resulting from yield improvements. Additionally, the increase was mitigated by a reduction in IT costs following the initiation of a new ERP implementation in 2023.

**25.** **Selling, general and administrative expenses**

Selling, general and administrative expenses consist primarily of payroll and personnel related costs, consulting and spending related to support the commercialization of the Genio system outside the U.S. and in the U.S. and to finance, information technology and human resource functions. Other general and administrative expenses include travel expenses, professional services fees, audit fees, insurance costs and general corporate expenses, including facilities-related expenses.

---

| | | | |
|:---|:---|:---|:---|
|  | **For the year ended December 31** | **For the year ended December 31** | **For the year ended December 31** |
| (in EUR 000) | **2025** | **2024** | **2023** |
| Staff costs | 26185 | 10665 | 8738 |
| Consulting and contractors' fees | 12513 | 11116 | 6801 |
| Legal fees | 1609 | 995 | 776 |
| Impairment loss on trade receivables | 503 |  |  |
| Rent | 493 | 639 | 317 |
| Facilities | 426 | 166 | 209 |
| Depreciation and amortization expense | 1324 | 1284 | 1042 |
| IT | 2002 | 1252 | 1190 |
| Travel | 2612 | 1024 | 934 |
| Insurance fees | 431 | 511 | 985 |
| Recruitment | 156 | 741 | 207 |
| Other | 10 | 68 | 488 |
| **Total selling, general and administrative expenses** | **48261** | **28461** | **21687** |

---

Selling, general and administrative expenses increased by €19.8 million, or 69.6 % from €28.5 million for the year ended December 31, 2024 to €48.3 million for the year ended December 31, 2025 mainly due to an increase in costs to support the commercialization of Genio system and the Company's overall scale-up preparations for the commercialization of the Genio system in the U.S. following receipt of FDA approval. Consulting and contractor fees also includes a provision for an amount of €0.7 million recognized under IAS 37 for the estimated future costs related to the replenishment of certain consumable components, reflecting a constructive obligation arising from business practices.

[**Table of Contents**](#TOC)

Selling, general and administrative expenses increased by €6.8 million, or 31.2% from €21.7 million for the year ended December 31, 2023 to €28.5 million for the year ended December 31, 2024 mainly due to an increase in costs to support the commercialization of Genio system outside the U.S. and scale up of the Company. As from 2024, consulting and contractor fees also include a provision in the amount of €0.7 million recognized under IAS 37 for the estimated future costs related to the replenishment of certain consumable components, reflecting a constructive obligation arising from business practices. This increase was partly offset by decrease in insurance and other.

**26.** **Other operating income and expenses**

The Company had other operating income of €1.3 million for the year ended December 31, 2025 compared to €1.0 million for the year ended December 31, 2024 and €0.5 million for the year ended December 31, 2023. The impact of the recoverable cash advances is further detailed in note 18.1.

---

| | | | |
|:---|:---|:---|:---|
|  | **For the year ended December 31** | **For the year ended December 31** | **For the year ended December 31** |
| (in EUR 000) | **2025** | **2024** | **2023** |
| Recoverable cash advances |  |  |  |
| &nbsp;&nbsp;Initial measurement and re-measurement | 1142 | 561 | 324 |
| R&D incentives | 236 | 530 | 1376 |
| Capitalization of R&D incentive | (99) | (83) | (1005) |
| Net loss on disposal of property, plant and equipment and right-of-use assets | (162) |  |  |
| Gain on lease modification | 119 |  |  |
| Other income/(expenses) | 38 |  | (151) |
| **Total other operating income** | **1274** | **1008** | **544** |

---

The other operating income contains the R&D Incentive in Australia and as from 2023 the tax incentive in Belgium as well. The incentives to be received relate to development expenses incurred by the subsidiary in Australia and Belgium. Refer to note 10 for more information on the tax incentive in Belgium. For the year ended December 31, 2025, €99,000 has been deducted from the expenses capitalized and for the year ended December 31, 2024, €83,000 has been deducted from the expenses capitalized in relation to this R&D Incentive. The R&D incentive and capitalization of R&D incentive for the year ended December 31, 2024 includes a correction of the R&D incentive in Belgium on the investments of 2023 for an amount of €93,000.

For the year ended December 31, 2025, the Company recognized a loss on disposal on property, plant and equipment for an amount of €170,000, a gain on disposal on right-of-use assets for an amount of €8,000 and a gain related to lease modifications for an amount of €119,000.

**27.**Employee benefits

---

| | | | |
|:---|:---|:---|:---|
|  | **For the year ended December 31** | **For the year ended December 31** | **For the year ended December 31** |
| (in EUR 000) | **2025** | **2024** | **2023** |
| Salaries | 31706 | 16969 | 16918 |
| Social charges | 3027 | 1799 | 1363 |
| Pension charges | 490 | 444 | 497 |
| Share-based payment (see note 16) | 4886 | 3968 | 2611 |
| Other | 632 | 603 | 1152 |
| **Total employee benefits** | **40741** | **23783** | **22541** |

---

---

| | | | |
|:---|:---|:---|:---|
|  | **For the year ended December 31** | **For the year ended December 31** | **For the year ended December 31** |
| (in EUR 000) | **2025** | **2024** | **2023** |
| Selling, general and administrative expenses | 26185 | 10665 | 8738 |
| Research & development expenses | 14556 | 13118 | 13803 |
| **Total employee benefits** | **40741** | **23783** | **22541** |

---

We refer to note 24 and 25 for more details on the increase in total employee benefits.

[**Table of Contents**](#TOC)

As at December 31, 2025, the Company employed 153.7 (2024: 183.6) full-time equivalents, including white-collar employees and consultants. The following table presents a breakdown of the Company's full-time equivalents as at December, 2025, 2024 and 2023:

---

| | | | |
|:---|:---|:---|:---|
|  | **As at December 31** | **As at December 31** | **As at December 31** |
| (in FTE's) | **2025** | **2024** | **2023** |
| Selling, general & administration | 81.2 | 56.5 | 40.4 |
| Research & Development | 72.5 | 127.1 | 106.4 |
| **Total** | **153.7** | **183.6** | **146.8** |

---

As at December 31, 2025, the Company had 51.0 full-time equivalents located in Belgium (2024: 66.0), 6.6 full-time equivalents located in Israel (2024: 45.2), 2.0 full-time equivalents located in Australia (2024: 3.0), 78.0 full-time equivalents located in USA (2024: 53.0), 16.1 full-time equivalents located in Germany (2024: 15.4) and 0.0 full-time equivalent located in UK (2024: 1.0).

&nbsp;&nbsp;&nbsp;&nbsp;**28.** **Pension schemes** 

**28.1. Defined contribution plan**

The Company offers Defined Contribution Plan funded through group insurances to its employees of the Israel entity. The total expense recognized in the consolidated income statement for contributions under this plan amounts to €159,000 (2024: €190,000).

**28.2. Defined benefit plan**

The Company offers a pension plan with a minimum return guaranteed by law to its employees of the Belgian entity. The contributions to this plan amount to minimum 7 % of the salary, partly paid by the employer and partly by the employees. As explained hereafter, this pension plan qualifies as Defined Benefit Plan under IFRS.

As a consequence of the law of December 18, 2015, minimum returns guaranteed by the employers are as follows:

&nbsp;&nbsp;&nbsp;&nbsp;● For the contributions paid as from January 1, 2016, a new variable return based on OLO rates comprised between 1.75 % and 3.75 %. The rate was 1,75% up to December 31, 2024 and has changed to 2.5% as from January 1, 2025.

&nbsp;&nbsp;&nbsp;&nbsp;● For the contributions paid until end December 2015, the previously applicable legal returns of 3.75 % on employee contributions and 3.25 % on employer contributions continue to apply until retirement date of the participants.

The insurance companies managing these plans for the Company also guarantee a minimum return on the reserves as well as on future contributions for some portions of the plan. They have evolved as follows: 4.75 % until 1998, 3.25 % from 1999 till 2012 and between 0.50 % and 2.25 % since 2013. They are currently set between 0.50 % and 1.50 %. The assets of the plan are entirely managed by external insurance companies "qualifying third party" which do not have any link with the Company.

The weighted average duration until the pension age for the Belgian plan is 18,1 years as at December 31, 2025. The weighted average duration is determined by considering the expected retirement ages of plan participants, adjusted for demographic factors such as mortality rates and turnover rates. Each participant's expected duration is weighted according to their respective projected benefit obligations, ensuring that the calculation reflects the financial impact of each participant on the overall pension liability. In view of the minimum legal returns guaranteed, this pension Plan qualifies as Defined Benefit Plan under IFRS. Indeed, it induces a financial risk for the Company during periods of declining market interest rates when the returns guaranteed by the insurance companies are lower than the minimum legal returns, which is currently the case. In this case, the intervention of the insurance company is limited, and the Company shall fund the balance between the return delivered by the insurance company and the legal return.

A complete actuarial calculation has been performed for this plan by external actuaries based on the "Projected Unit Credit Method without future contribution" according to the IAS 19,115 as follows:

&nbsp;&nbsp;&nbsp;&nbsp;● Projection of the minimum return guaranteed by the law till the retirement date and discounting of this amount with the discount rate used for the valuation (rate of high-quality corporate bonds);

&nbsp;&nbsp;&nbsp;&nbsp;● The discounted net obligation is the maximum between this discounted projection and the projection of the accrued reserves discounted at the discount rate used for the valuation (rate of high-quality corporate bonds).

[**Table of Contents**](#TOC)

There was no net defined benefit obligation established as of December 31, 2025 (2024: no net defined benefit obligation):

---

| | | |
|:---|:---|:---|
| (in EUR 000) | **2025** | **2024** |
| Net defined benefit liability at January 1 |  | 9 |
| Defined benefit cost included in profit or loss | 327 | 251 |
| Total remeasurement included in OCI | 18 | (11) |
| Employer contributions | (345) | (249) |
| **Net defined benefit liability at December 31** | **—** | **—** |

---

The gross defined benefit liability is as follows:

---

| | | |
|:---|:---|:---|
| (in EUR 000) | **2025** | **2024** |
| Gross defined benefit liability at January 1 | 973 | 764 |
| Current service cost | 331 | 254 |
| Interest cost | 35 | 25 |
| Administrative expenses | (5) | (4) |
| Taxes on contributions | (15) | (11) |
| Return on plan assets | (1) | (53) |
| Insurance premiums for risk benefits | (14) | (10) |
| Actuarial loss due to change in experience assumptions | (50) | 8 |
| **Gross defined benefit liability at December 31** | **1254** | **973** |

---

The fair value of the plan assets is as follows:

---

| | | |
|:---|:---|:---|
| (in EUR 000) | **2025** | **2024** |
| Fair value plan assets at January 1 | 973 | 755 |
| Interest income | 39 | 28 |
| Employer contributions | 345 | 250 |
| Administrative expenses | (5) | (4) |
| Taxes on contributions | (15) | (11) |
| Insurance premiums for risk benefits | (14) | (10) |
| Return on plan assets | (1) | (53) |
| Actuarial gain on fair value of the plan assets | (68) | 18 |
| **Fair value plan assets at December 31** | **1254** | **973** |

---

The number of members and the average age of the members is as follows:

---

| | | |
|:---|:---|:---|
|  | **For the year ended December 31** | **For the year ended December 31** |
|  | **2025** | **2024** |
| Active members | 49 | 47 |
| Average age | 40 | 39 |

---

All plan assets are invested in an insurance contract with guaranteed interest rate (branch 21 product). The defined benefit calculation has been performed based on the below assumptions:

---

| | | |
|:---|:---|:---|
|  | **For the year ended December 31** | **For the year ended December 31** |
|  | **2025** | **2024** |
| Discount rate | 4.4% | 3.7% |
| Inflation rate | 2.0% | 2.2% |
| Salary increase (in excess of inflation) | 1.0% | 1.0% |
| Withdrawal rate based on age (minimum) | 0.0% | 0.0% |
| Withdrawal rate based on age (maximum) | 12.0% | 12.0% |

---

[**Table of Contents**](#TOC)

The discount rate was derived from the EIOPA term structure on each valuation date, considering the weighted average duration of liabilities. The inflation rate is based on the long-term objective of the European Central Bank. Retirement age assumption is in line with current legal requirements. The withdrawal rate and the salary increase rate reflect the expectations of the company on a long-term basis.

A sensitivity with reasonable possible changes on the discount rate will impact the net defined benefit liability as follows (positive = increase net defined benefit liability / negative = decrease of net defined benefit liability):

---

| | | |
|:---|:---|:---|
|  | **For the year ended December 31** | **For the year ended December 31** |
|  | **2025** | **2024** |
| Increase of 0.25% in the discount rate |  |  |
| Decrease of 0.25% in the discount rate |  |  |

---

The expected employer contributions for the year 2025 amount to €354,000.

The total expected benefit payments in the next 10 years, with the remainder to be paid in the period thereafter are:

---

| | |
|:---|:---|
|  | **As at** |
|  | **December 31,**  |
| (in EUR 000) | **2025** |
| In the next 12 months |  |
| Between 2 and 5 years |  |
| Between 6 and 10 years | 243 |

---

**29.** **Financial income**

---

| | | | |
|:---|:---|:---|:---|
|  | **For the year ended December 31** | **For the year ended December 31** | **For the year ended December 31** |
| (in EUR 000) | **2025** | **2024** | **2023** |
| Interests | 1834 | 2502 | 2571 |
| Exchange differences | 2463 | 4925 | 1254 |
| Fair value adjustment foreign currency swaps | 4 |  | 343 |
| Fair value adjustment synthetic warrants | 1603 |  |  |
| Other | 24 | 20 | 6 |
| **Total financial income** | **5928** | **7447** | **4174** |

---

The financial income decreased by €1.5 million from €7.4 million for the year ended December 31, 2024 to €5.9 million for the year ended December 31, 2025 due to a decrease in exchange results by €2.5 million and a decrease in interests by €0.7 million, partially offset by an increase in fair value adjustment on the synthetic warrants by €1.6 million.

The financial income increased by €3.3 million from €4.2 million for the year ended December 31, 2023 to €7.4 million for the year ended December 31, 2024 mainly due to an increase in exchange results.

For the year ended December 31, 2025, the exchange gains amount to €2.5 million which consist of €2.4 million realized exchange gains and €96,000 unrealized exchange gains. The realized exchange gains relate to currency swaps and forwards and USD financial assets (note **15**).

For the year ended December 31, 2024, the exchange gains amount to €4.9 million which consist of €2.9 million realized exchange gains and €2.0 million unrealized exchange gains. The realized exchange result is mainly related to the USD financial assets that came to end in the second half of 2024. The unrealized exchange result is mainly related to the revaluation of both the Company's USD cash balance and USD financial assets (note **15**). For the year ended December 31, 2023, the closing rate of USD/EUR amounted to 1.103765, while as at December 31, 2024, the rate of USD/EUR decreased to 1.0389, resulting in unrealized exchange gains on the USD balances.

For the year ended December 31, 2025, the total interest income amounted to €1.8 million (2024: €2.5 million and 2023: €2.6 million). This interest income relates to the term accounts.

[**Table of Contents**](#TOC)

The fair value adjustment foreign currency swaps and forwards relates to the fair value adjustment on foreign currency swaps and forwards. More information can be found in note 21.1

The fair value adjustment of synthetic warrants is related to the EIB loan facility agreement. More information can be found in note 18.2.

**30.**Financial expense

---

| | | | |
|:---|:---|:---|:---|
|  | **For the year ended December 31** | **For the year ended December 31** | **For the year ended December 31** |
| (in EUR 000) | **2025** | **2024** | **2023** |
| Fair value adjustment foreign currency swaps and forwards |  | 353 | 90 |
| Fair value adjustment synthetic warrants |  | 35 |  |
| Fair value adjustment prepayment option  | 21 | 15 |  |
| Fair value adjustment convertible bond | 51 |  |  |
| Transaction costs convertible bond | 3149 |  |  |
| Amortization day 1 loss convertible bond | 106 |  |  |
| Recoverable cash advances, Accretion of interest | 1079 | 1037 | 990 |
| Interest and bank charges | 1570 | 736 | 88 |
| Interest on lease liabilities | 121 | 150 | 129 |
| Exchange differences | 5422 | 2744 | 2432 |
| **Total financial expense** | **11519** | **5070** | **3729** |

---

**The financial expenses increased by €6.4 million from €5.1 million for the year ended December 31, 2024 to €11.5 million for the year ended December 31, 2025 mainly due to an increase in exchange results by €2.5 million and an increase in interest and bank charges by €0.7 million.**

**The financial expenses increased by €1.3 million from €3.7 million for the year ended December 31, 2023 to €5.1 million for the year ended December 31, 2024 mainly due to an increase in fair value adjustments (note 20.1), an increase in interest and bank charges and an increase in exchange differences.**

**For the year ended December 31, 2025, exchange losses amount to €5.4 million which consist of €3.7 million realized exchange losses and €1.8 million unrealized exchange losses. The unrealized exchange result is mainly relate to the revaluation of both the Company's USD cash balance and USD financial assets.**

**For the year ended December 31, 2024, exchange losses amount to €2.7 million which consist of €1.6 million realized exchange losses and €1.1 million unrealized exchange losses. The realized exchange result is mainly related to the USD financial assets that came to end in the first half of 2024. The unrealized exchange result is mainly driven by the monthly revaluation on balance sheet items such as bank balances and vendor payables.**

The Company holds both EUR and USD balances, each used to settle expenses in their respective currencies.

While the Company does hedge a few transactions using swap contracts, the Company does not apply hedge accounting. The swap instruments are short-term and mainly used to manage transactional exposures in GBP, ILS, and CHF. Although GBP sales are expected to cover GBP costs going forward, some contracts have been used to address short-term needs. In addition, a few swaps were used to neutralize the currency impact of our USD-denominated T-bills, which were purchased using EUR balances for convenience, in line with the portfolio allocation approved by the board.

The main contributor to the exchange loss is explained by the fact that the majority of the cash held by the Belgian subsidiary is held in USD to cover future USD expenses. As a result, the recent appreciation of the euro, approximately 13% between January 1 and December 31, 2025, has led to a significant unrealized FX loss upon translation of USD cash to the functional currency of the subsidiary which is EUR.

#### The discounting impact of the recoverable cash advances is further detailed in note 18.1.

[**Table of Contents**](#TOC)

**The fair value adjustment foreign currency swaps and forwards relates to the fair value adjustment on foreign currency swaps and forwards. More information can be found in note 21.1.**

**The increase in interest and bank charges for the year ended December 31, 2025 can be explained by the interest charge on the EIB financial debt. The fair value adjustments of synthetic warrants and prepayment option are also related to the EIB loan facility agreement. More information can be found in note 18.2.**

**More information on the fair value adjustment on the convertible bond, the amortization of the day 1 loss and the transaction costs related to the convertible bond can be found in note 18.3.**

**31.**Income taxes and deferred taxes

The major components of income tax expense for the years ended December 31, 2025, 2024 and 2023 are as follows:

---

| | | | |
|:---|:---|:---|:---|
|  | **For the year ended December 31** | **For the year ended December 31** | **For the year ended December 31** |
| (in EUR 000) | **2025** | **2024** | **2023** |
| Current tax income/(expense): | (1040) | (2811) | 1442 |
| which consists of: |  |  |  |
| Current tax income/(expense) for the year | (1026) | (2963) | 2152 |
| Current tax income/(expense) for prior periods | (14) | 152 | (710) |
| Deferred tax income/(expense) | 31 | 7 | 3 |
| **Total income tax income/(expense)** | **(1009)** | **(2804)** | **1445** |

---

As of January 1, 2022, new tax regulations are in place in the US in which R&D expenses could no longer be deducted when incurred but instead they should be capitalized only for tax purposes and amortized over a 5 year period. A current tax liability was recognized. During 2023, the Company finalized its R&D tax credit study and reached the conclusion that R&D expenses can be deducted when incurred. The R&D tax credit study concluded that taking into account that the research and development by the US subsidiary was done under the direction of the parent in Belgium and benefited Belgian parent' business, the expenditures in the US should be deducted when incurred. As a result the current tax liability which was outstanding as at December 31, 2022 amounting to €1.6 million was reversed.

The current tax expense mainly relates to (i) reversal of the accrual of the liability of uncertain tax position for an amount of €0.5 million (2024: accrual of the liability of uncertain tax position for an amount of €2.2 million. and (ii) income tax paid or payable by certain of the Company's subsidiaries for an amount of €1.6 million (2024: €0.6 million).

The current tax liability of €3.9 million includes a liability for uncertain tax positions for an amount of €3.3 million and an income tax liability for an amount of €0.7 million. The uncertain tax position was recorded following certain public rulings and new guidance issued by tax authorities in one of the jurisdictions that the Company operates in. During the year 2024, the Company reassessed its uncertain tax position in light of new guidance, rulings, and precedents issued by tax authorities in one of the jurisdictions in which it operates. As a result of this reassessment, the Company recorded an updated provision to reflect the updated interpretation of the applicable tax regulations and the associated potential exposure.

The deferred tax relates to subsidiaries where some payroll accruals, right-of-use assets and lease liabilities are temporary differences in the determination of the taxable income. These temporary differences generate deferred tax income/(expense) of € 31,000 in 2025, € 7,000 in 2024 and €3,000 in 2023.

[**Table of Contents**](#TOC)

The income tax expenses can be reconciled to the Company's Belgian statutory income tax rate of 25% (25% in 2024) as follows:

---

| | | | |
|:---|:---|:---|:---|
|  | **For the year ended December 31** | **For the year ended December 31** | **For the year ended December 31** |
| (in EUR 000) | **2025** | **2024** | **2023** |
| Loss for the period before taxes | (89076) | (56432) | (44657) |
| Company statutory income tax rate | 25.00% | 25.00% | 25.00% |
| Income tax at company statutory tax rate | 22269 | 14108 | 11164 |
| Foreign tax rate differential | 223 | 217 | 93 |
| Unrecognized DTA on tax losses and temporary differences | (22103) | (13991) | (10660) |
| Release of the non-recognition of DTA |  | 6 | 2332 |
| Non deductible expenses | (774) | (610) | (387) |
| Share based payments | (1221) | (992) | (653) |
| Income not subject to tax | 151 | 269 | 112 |
| Tax adjustments to the previous period | (14) | 152 | (710) |
| Local income taxes | 515 | (2173) | 46 |
| Other | (55) | 210 | 108 |
| **Income tax at company effective tax rate** | **(1009)** | **(2804)** | **1445** |
| Company effective income tax rate | (1.13)% | (4.97)% | 3.24% |

---

The tax adjustments to the previous period and release of the non-recognition of DTA in 2023 relates to the reversal of the current tax liability in the US subsidiary due to the R&D tax credit study (see above for more information).

The local income taxes in the effective tax rate reconciliation mainly relates to the theoretical tax exposure on R&D costs in the Australian subsidiary.

The Belgian entity and the Australian entity have historical losses that can be carried forward to future taxable income. The Belgian entity has tax losses for €300.0 million as at December 31, 2025 (2024: €213.5 million, 2023: €153.6 million). The Australian entity has tax losses for €3.1 million as at December 31, 2025 (2024: €2.8 million, 2023: €1.8 million). Due to the fact that these entities are not expected to generate significant profits in the near future, no deferred tax assets on tax losses carried forward and temporary differences have been recognized at this stage.

Deferred tax assets and liabilities are detailed below by nature of temporary differences for the year ended December 31, 2025 and 2024:

---

| | | | |
|:---|:---|:---|:---|
|  | **As at December 31, 2025** | **As at December 31, 2025** | **As at December 31, 2025** |
| (in EUR 000) | **Assets** | **Liabilities** | **Net** |
| Intangible assets | 742 |  | 742 |
| Property, plant and equipment | 10 | (19) | (9) |
| Right-of-use assets |  | (299) | (299) |
| Other current assets | 5 | (20) | (15) |
| Financial debt (recoverable cash advances, EIB loan and derivatives) | 2067 | (677) | 1390 |
| Lease liabilities | 329 |  | 329 |
| Other current liabilities | 115 | (60) | 55 |
| Other non-current assets |  | (23) | (23) |
| Tax-losses carried forward | 75963 |  | 75963 |
| **Total gross deferred tax assets/(liabilities)** | **79231** | **(1098)** | **78133** |
| Netting by tax entity | (1098) | 1098 |  |
| Unrecognized deferred tax assets | (78046) |  | (78046) |
| **Total deferred tax assets/(liabilities)** | **87** | **—** | **87** |

---

[**Table of Contents**](#TOC)

---

| | | | |
|:---|:---|:---|:---|
|  | **As at December 31, 2024** | **As at December 31, 2024** | **As at December 31, 2024** |
| (in EUR 000) | **Assets** | **Liabilities** | **Net** |
| Intangible assets | 1242 |  | 1242 |
| Property, plant and equipment | 9 | (16) | (7) |
| Right-of-use assets |  | (760) | (760) |
| Other current assets | 5 |  | 5 |
| Financial debt (recoverable cash advances and derivatives) | 2057 | (805) | 1252 |
| Lease liabilities | 796 |  | 796 |
| Retirement benefit obligations |  |  |  |
| Other current liabilities | 48 | (40) | 8 |
| Other non-current assets |  | (28) |  |
| Tax-losses carried forward | 54100 |  | 54100 |
| **Total gross deferred tax assets/(liabilities)** | **58257** | **(1649)** | **56636** |
| Netting by tax entity | (1630) | 1630 |  |
| Unrecognized deferred tax assets | (56551) |  | (56551) |
| **Total deferred tax assets/(liabilities)** | **76** | **(19)** | **85** |

---

The Company accumulates tax losses that are carried forward indefinitely for offset against future taxable profits of the Company. As stated above, the entities accumulating tax losses are not expected to generate significant profits in the near future so no deferred tax assets on tax losses carried forward and temporary differences have been recognized at this stage. The recognized deferred tax assets and liabilities in the consolidated balance sheets of the Company are positions that arise in the subsidiary in Israel and US.

**32.**Loss per share (EPS)

The Basic Earnings Per Share and the Diluted Earnings Per Share are calculated by dividing earnings for the year by the weighted average number of shares outstanding during the year. As the Company is incurring net losses, outstanding warrants have no dilutive effect. As such, there is no difference between the Basic and Diluted EPS.

EPS for December 2025 has been presented in the income statement taking into account resolutions adopted by the shareholders' meeting of February 21, 2020. All existing preferred shares were converted into common shares, and then a share split of 4:1 was approved by the shareholders' meeting.

---

| | | | |
|:---|:---|:---|:---|
|  | **2025** | **2024** | **2023** |
| *As at December 31, after conversion and share split* |  |  |  |
| Outstanding common shares at period-end | 43026460 | 37427265 | 28673985 |
| Weighted average number of common shares outstanding | 38108434 | 32743605 | 27968142 |
| Potential number of shares resulting from the exercise of warrants | 3207819 | 2258319 | 1635606 |
| Potential number of shares resulting from conversion of the bond | 4510356 |  |  |

---

Basic and Diluted EPS for the periods ended December 31, 2025, 2024 and 2023 based on weighted average number of shares outstanding after conversion and share split are as follows:

---

| | | | |
|:---|:---|:---|:---|
|  | **For the period ended December 31** | **For the period ended December 31** | **For the period ended December 31** |
|  | **2025** | **2024** | **2023** |
| Loss of year attributable to common holders (in EUR) | (90085000) | (59236000) | (43212000) |
| Loss of year attributable to preferred holders (in EUR) |  |  |  |
| Loss of year attributable to equity holders (in EUR) | (90085000) | (59236000) | (43212000) |
| Weighted average number of common shares outstanding (in units) | 38108434 | 32743605 | 27968142 |
| Basic earnings per share in EUR (EUR/unit) | (2.364) | (1.809) | (1.545) |
| Diluted earnings per share in EUR (EUR/unit) | (2.364) | (1.809) | (1.545) |

---

[**Table of Contents**](#TOC)

**33.**Other commitments

**33.1. Capital commitments**

There are no commitments related to capital expenditures at the closing date.

**33.2. Lease expenses**

The lease expense recognized in the income statement related to low-value leases and short-term leases amounts to:

---

| | | | |
|:---|:---|:---|:---|
|  | **For the year ended December 31** | **For the year ended December 31** | **For the year ended December 31** |
| (in EUR 000) | **2025** | **2024** | **2023** |
| Expense | 198 | 135 | 202 |
| **Total** | **198** | **135** | **202** |

---

**33.3. Other commitments**

There are no other commitments.

**34.**Related parties

Transactions between the Company and its subsidiaries have been eliminated in consolidation and are not disclosed in the notes. Related party transactions are disclosed below.

**34.1. Remuneration of key management**

Key management consists of the members of executive management which consists of the Chief Executive Officer (CEO), the Chief Financial Officer (CFO), the Chief Commercial Officer (CCO) and the Chief Technology Officer (CTO) of the Company.

For the period ended December 31, 2025 and December 31, 2024, the table below includes the remuneration package of all members of executive management.

---

| | | |
|:---|:---|:---|
|  | **For the period ended**  | **For the period ended**  |
|  | **December 31** | **December 31** |
| (in EUR 000) | **2025** | **2024** |
| Short-term remuneration & compensation (1) | 2053 | 2038 |
| Post-employment benefits | 88 | 49 |
| Share-based payment (2) | 1313 | 2314 |
| **Total** | **3454** | **4401** |

---

&nbsp;&nbsp;&nbsp;&nbsp;(1) Includes base remuneration, fringe benefits, short term (one-year) performance related bonus (i.e. variable remuneration), sign-on bonuses.

&nbsp;&nbsp;&nbsp;&nbsp;(2) Warrant expense under IFRS 2.

[**Table of Contents**](#TOC)

**34.2. Relationship and transactions with non-executive directors and holders of more than 3% of our share capital:**

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **For the period ended December 31, 2025** | **For the period ended December 31, 2025** | **For the period ended December 31, 2024** | **For the period ended December 31, 2024** |
|  |  |  | **Set up of** |  |
|  | **Set up of** | **Board** | **Production** | **Board** |
| (in EUR 000) | **Production Line** | **Remuneration** | **Line** | **Remuneration** |
| Cochlear | 52 |  | 242 |  |
| Robert Taub (until June 12, 2024)/ Robelga SRL (since June 12, 2024) |  | 119 |  | 122 |
| Kevin Rakin |  | 79 |  | 66 |
| Pierre Gianello |  | 60 |  | 59 |
| Jurgen Hambrecht |  | 71 |  | 65 |
| Rita Mills |  | 68 |  | 65 |
| Giny Kirby |  | 57 |  | 58 |
| Wildman Venturees LLC |  | 79 |  | 70 |
| **Total** | **52** | **532** | **242** | **571** |
| **Amounts outstanding at year-end** | **—** | **117** | **—** | **110** |

---

For the period ended December 31, 2025, our non-executive directors were: Robert Taub (until June 12, 2024), Robelga SRL (permanently represented by Robert Taub) (as from June 12, 2024), Kevin Rakin, Pierre Gianello, Jürgen Hambrecht, Rita Johnson-Mills, Virigina Kirby and Wildman Ventures, LLC (permanently represented by Daniel Wildman). During the period ended December 31, 2025 and December 31, 2024, all our non-executive directors were granted "RSUs" in accordance with the Company's remuneration policy. None of the non-executive directors were granted warrants during the period ended December 31, 2025 and December 31, 2024. The warrant expense under IFRS 2 related to the warrants that were granted to the non-executive directors amounted to €1.4 million for the period ended December 31, 2025 and €218,000 for the period ended December 31, 2024.

**The Company and Cochlear Limited, or Cochlear, have entered into a collaboration agreement, dated January 2023, related to the transfer of assets and related support for the setting up of a production line in the U.S. This statement scope of work led to a financial impact of € 52,000 for the period ended December 31, 2025, compared to an impact of €242,000 for the period ended December 31, 2024 and was recognized as part of assets under construction.**

On September 28, 2023, the Company announced a partnership with ResMed in Germany to increase OSA awareness and therapy penetration in the German market. The Company and ResMed Germany will establish a continuum of care that will educate and guide OSA patients in the German market from diagnosis through treatment. Together, the companies will work to accelerate patient identification and better support patient set-up on the appropriate therapy.

Effective as of October 1, 2024, the Company entered into a collaboration agreement with Man & Science SA to develop a miniaturized injectable neuromodulation device. The Company retains exclusive rights for its use in treating obstructive sleep apnea.

[**Table of Contents**](#TOC)

**34.3. Relationship and transactions with members of key management**

For the period ended December 31, 2025, our key management consisted of the members of executive management: Olivier Taelman (CEO), John Landry (CFO), Scott Holstine (CCO) and Bruno Onkelinx (CTO).

For the period ended December 31, 2024, our key management consisted of the members of executive management: Olivier Taelman (CEO for the full year), Loic Moreau (CFO until November 4, 2024), John Landry (CFO as from November 4, 2024), Scott Holstine (CCO as from July 15, 2024) and Bruno Onkelinx (CTO for the full year).

From September 1, 2021 until August 19, 2024, Olivier Taelman performed his function as CEO of the Company on a self-employed basis in accordance with a service agreement between Nyxoah SA and Olivier Taelman. As from August 19, 2024, Olivier Taelman temporarily relocated to the U.S. Since then, he performs his function as CEO of the Company partially on a self-employed basis in accordance with a service agreement between Nyxoah SA and Olivier Taelman and partially as employee of Nyxoah Inc. As from September 1, 2025, Olivier Taelman moved back to Belgium and from that date he is performing his function as CEO of the Company on a self-employed basis in accordance with a service agreement between Nyxoah SA and Olivier Taelman.

Loïc Moreau and Bruno Onkelinx are employees of Nyxoah SA. John Landry and Scott Holstine are employees of Nyxoah Inc.

All members of our key management were granted warrants during the period ended December 31, 2025 and December 31, 2024.

**35.** **Events after the balance-sheet date**

On February 20, 2026, the Company issued 635,943 shares to settle the first amortization payment amount (including any accrued interest thereon) for a total amount of EUR 2,158,899.75 under the convertible bonds issued on December 18, 2025.

The Company confirms that despite the recent conflict between Israel and Iran, operations are continuing with no major impact and the assets are currently safeguarded. The Company is not suffering impact of this conflict.

## Exhibit 1.1

**Exhibit 1.1**

*English translation, for information purposes only*

**NYXOAH SA**

**Rue Edouard Belin 12**

**B-1435 Mont-Saint-Guibert**

**Register of legal entities of Walloon Brabant**

**VAT: BE 0817.149.675**

**CONSOLIDATED VERSION OF THE ARTICLES OF ASSOCIATION**

**AS PER NOVEMBER 20, 2025**

**TITLE I. Legal form, name, registered office, object and duration**

**Article 1** **Legal form - Name**

The company has the legal form of a public limited liability company (*naamloze vennootschap/société anonyme*).

The name of the company is "**Nyxoah**". This name shall always be preceded or followed by the words "société anonyme" or the abbreviation "SA" in French.

**Article 2** **Registered office, e-mail address and website**

The registered office of the company is located in the Walloon Region.

The board of directors may transfer the company's registered office, provided the transfer does not result in a change to the language of the articles pursuant to the applicable linguistic rules. Such decision does not require an amendment to the articles of association, unless the company's registered office is transferred to another Region. In this case, the board of directors has the power to amend the articles.

If, due to a transfer of the company's registered office, the language of the articles of association must be changed, only the general shareholders' meeting has the power to take the decision, in accordance with the rules applicable to amendment of the articles of association.

The company may establish, by a simple decision of the board of directors, management offices, subsidiaries or branches in Belgium or abroad.

The company's website is the following: www.nyxoah.com

For purposes of communication as referred to in article 2:31 of the Code of Companies and Associations, the company can be contacted on the following e-mail address: corporate@nyxoah.com.

The board of directors may modify the e-mail address and the website of the company in accordance with the provisions of the Code of Companies and Associations.

------

*English translation, for information purposes only*

**Article 3** **Purpose**

The purpose of the company is, both in Belgium and abroad, in its own name and for its own account, the research and development, the manufacturing and the sale of medical devices.

For this purpose, the company may, in any manner, collaborate and participate, or take an interest in other companies, directly or indirectly.

The company may guarantee to secure its own obligations or those of third parties by, among other things, granting a mortgage or pledge over its assets, including its own business assets.

The company may generally carry out all commercial, industrial, financial, movable or real estate transactions which directly or indirectly relate to its purpose or which could facilitate the realisation thereof.

**Article 4** **Term**

The company is established for an unlimited duration.

**TITLE II. Capital – Shares**

**Article 5** **Capital**

The capital amounts to six million five hundred four thousand six hundred eighty-eight euro seventy-six cent (EUR 6,504,688.76).

It is represented by forty-three million twenty-six thousand four hundred sixty (43,026,460) shares, without nominal value, each representing an equal part of the company's capital.

**Article 6** **Nature of the shares - Exercise of rights attached to Shares**

The shares shall be in registered or dematerialized form, at the discretion of their owner or holder (hereinafter, both the "**Holder**") and within the limits set by applicable law. The Holder may at any time, at its expense, request the conversion of registered shares into a dematerialized form and vice versa.

The register of all registered shares can be held in electronic form. The board of directors can decide to entrust a third party with keeping and the administration of the electronic register.

The shares are indivisible vis-à-vis the company. If a share belongs to different persons, if the rights attached to a share are divided over different persons, or if different persons hold rights in rem to the same shares, the board of directors may suspend the exercise of the rights attached thereto until one single person has been designated as shareholder vis-à-vis the company and notification thereof has been given to the company. All convocations, notifications and other announcements by the company to the different persons entitled to one share are made validly and exclusively to the designated common representative.

------

*English translation, for information purposes only*

The rights attached to shares that are pledged or subject to usufruct shall be exercised by the owner-pledgor and the person having the usufruct, respectively, unless agreed otherwise in an agreement signed by all relevant parties and notified to the company.

**Article 7** **Authorised capital**

The board of directors is authorised to increase the capital of the company on one or several occasions in accordance with the Code of Companies and Associations by a maximum aggregate amount of three million four hundred thirty-six thouand euro (EUR 3,436,000).

This authorisation is valid for a period of five years as from the date of publication in the Annexes to the Belgian State Gazette of an extract of the minutes of the extraordinary shareholders' meeting of the company held on 12 June 2024.

Every capital increase decided upon by the board of directors in the context of authorised capital shall be effected in accordance with the modalities to be determined by the board of directors, and may amongst others be achieved (i) by contributions in cash or in kind, or a combination of both, (ii) by capitalisation of reserves, whether available or unavailable for distribution, and capitalisation of issue premiums, (iii) with or without the issuance of new shares (at, above or below the par value and with or without issue premium), with or without voting rights, that will have the rights as will be determined by the board of directors, or (iv) with issuance of convertible bonds or warrants, bonds with warrants or other securities.

The board of directors is authorized, when exercising its powers within the framework of the authorized capital, to restrict or cancel, in the interest of the company, the preferential subscription rights of each shareholder, and - as far as needed and applicable - of each holder of subscription rights issued by the Company. This restriction or cancellation of the preferential subscription rights can also be done in favor of members of the personnel of the company or of its subsidiaries, or in favor of one or more persons other than members of the personnel of the company or of its subsidiaries.

In the event of a capital increase decided by the board of directors within the framework of the authorised capital, any issue premiums shall be booked on one or more separate reserve accounts "issue premiums".

The board of directors is also expressly authorised to increase the company's capital after having been notified by the FSMA that the company is the subject of a public takeover bid. This authorisation is valid with respect to the public takeover offers of which the FSMA has notified the company no later than three years following 7 September 2020.

The board of directors is also authorized, with the right of substitution, to amend the company's articles of association after each capital increase that has occurred within the framework of the authorised capital, in order to align them with the new situation of the capital and the shares.

**Article 8** **Calls for payment**

The board of directors independently decides on calls for payment on shares which have not been entirely liberated.

------

*English translation, for information purposes only*

Each payment called is accounted to all of the shares of which the shareholder is the owner.

The board of directors can authorise shareholders to pre-pay uncalled capital on their shares. In this case, the board of directors will fix the terms pursuant to which these prepayments will be permitted. The prepayments will qualify as advances.

Any shareholder who is in default of payments called, automatically has to pay the company interest at the statutory rate increased by two percent, as from the date such payment call was originally due and the voting rights attached to the relevant shares shall be suspended automatically for as long as the relevant payments have not been made.

The board of directors can, if such failure is not remedied within one month of a notice of default (or such other period as the board of directors may decide), cause such shares to be sold on the stock exchange, with or without the assistance of an intermediary, without prejudice to the right to claim from such shareholder any amount that remains outstanding plus such damages and interests as may apply.

**Article 9** **Capital reduction**

The capital of the company can be reduced in accordance with the applicable legal provisions.

**Article 10** **Acquisition, pledge and disposal of own shares**

The company may acquire, pledge and dispose of its own shares in accordance with the applicable legal provisions.

**Article 11** **Other securities**

The company is authorised to issue all securities not prohibited by or pursuant to the law. These securities may be in registered form or dematerialised.

**Article 12** **Disclosure of major shareholdings**

Without prejudice to the applicable legal provisions relating to the disclosure of significant shareholdings, every natural person or legal entity that acquires, directly or indirectly, securities of the company granting voting rights, whether they represent the company's capital or not, must notify the board of directors of the company and the FSMA of the number and percentage of existing voting rights he or she holds, whether directly or indirectly, or whether alone or in concert with one or several other persons, as a result of the acquisition, if the voting rights attached to the securities granting voting rights reach or exceed 3%, 5%, 10%, 15%, 20%, or any further multiple of 5% of the total outstanding voting rights. Without prejudice to the applicable legal provisions relating to the disclosure of significant shareholdings, the same notification is required when, as a result of the transfer of securities, the number of voting rights drops below one of the aforementioned thresholds.

------

*English translation, for information purposes only*

**TITRE III. Management and audit**

**Article 13** **Composition of the board OF DIRECTORS**

The company is managed by a board of directors composed of at least three members, natural or legal entities, who need not be a shareholder.

Directors are appointed by the general shareholders' meeting. The duration of their mandate may not exceed four years. Directors whose mandate came to an end may be reappointed.

In the event of one or more vacancies, the remaining directors, at a board meeting, shall be empowered to provisionally fill the vacancies, until the next general shareholders' meeting. The first general shareholders' meeting that follows shall decide whether to confirm the appointment of the co-opted director(s).

The general shareholders' meeting may remove a director from office at any time, with immediate effect and without cause.

When a legal entity is appointed as director of the company, such legal entity must appoint a permanent representative in accordance with the applicable legal provisions.

**Article 14** **Chairperson of the board of directors**

The board of directors elects a chairperson from among its members. The chairperson of the board of directors may elect a vice-chairperson. If no chairperson has been appointed or if he or she is absent or hindered, the meeting shall be chaired by the vice-chairperson, if appointed and not absent or hindered, or otherwise by the oldest director.

**Article 15** **Remuneration**

The general shareholders' meeting can decide whether or not the mandate of the directors is remunerated by awarding a fixed and/or variable remuneration.

The amount thereof is determined by the general shareholders' meeting and will be borne by the general expenses of the company. The general shareholders' meeting can determine the aggregate amount of the remuneration allocated to the directors, who shall then divide this amount among themselves.

Unless the general shareholders' meeting decides otherwise, the mandate of a director is deemed not to be remunerated.

The board of directors is authorised to award an extraordinary remuneration to directors who are charged with special functions or assignments. This extraordinary remuneration shall be booked as company expense.

The restrictions provided for in Article 7:91 of the Code of Companies and Associations shall not apply to the Company in respect of any persons falling within the scope of these provisions (whether directly, pursuant to Article 7:121 of the Code of Companies and Associations, or otherwise).

------

*English translation, for information purposes only*

**Article 16** **Meetings**

The board of directors shall meet as frequently as the interest of the company requires. The board of directors shall meet when convened by the chairperson or, in case he or she is absent or hindered, a vice-chairperson, if any, or, in the absence the latter, by a director appointed by the other directors. A board meeting must be called upon the request of two or more directors.

Unless all directors agree otherwise, convening notices must be given at least four (4) calendar days before the board meeting, except in case of emergency. In case of emergency, the convening notice must be given with not less than two (2) business days' notice, and the reasons for the emergency should be specified in the notice.

Convening notices are valid if delivered by ordinary letter, e-mail or any other means of communication specified in Article 2281 of the Belgian Civil Code. Board meetings are held at the registered office or at the place indicated in the convening notice. Each director can instruct, by means of an ordinary letter, e-mail or any other means of communication or medium bearing his or her signature (including an electronic signature), another director to represent him or her it at a specified board meeting and to vote in his or her place. In that case, the instructing director shall be deemed present. A director can represent multiple members of the board of directors and can, in addition to his or her own vote, cast as many votes for which he or she has a proxy from other directors.

Board meetings can be held by using any telecommunication means permitting a joint discussion, such as telephone conferencing or video conferencing. Directors taking part in a meeting held by telephone conferencing or video conference shall be deemed present at the meeting.

At least half of the directors need to be present or represented to have a quorum. If the quorum is not reached, each director shall be entitled to convene a second meeting that may validly deliberate and decide on the items that were on the agenda of the first meeting regardless of the number of directors present or represented, provided that at least two (2) directors are present. The convening notice for such second board meeting needs to be sent at least seven (7) calendar days prior to the date of the second meeting, unless in case of emergency the reasons of which should then be specified in the convening notice.

The board of directors can only validly deliberate on items that are not mentioned on the agenda, if all directors are present or represented at the board meeting and unanimously consent to do so. This consent is assumed to have been given if no objection is recorded in the minutes.

Board resolutions can also be adopted by unanimous written consent of all directors. This written procedure cannot be used to establish the annual financial statements or to use the authorised capital. Unless specified otherwise, the resolutions adopted by unanimous written consent shall be deemed to have been taken at the seat of the company on the date that they are signed by the last director.

------

*English translation, for information purposes only*

**Article 17** **Deliberations and resolutions**

Unless otherwise provided in these articles of association, the board resolutions shall be adopted by a simple majority of the votes cast by the directors present or represented at the board meeting, and in case of abstentions, by a simple majority of the votes of the other directors present or represented at the board meeting.

Each director has one (1) vote, but can, in addition to his or her own vote, cast as many votes for which he or she has a proxy from other directors.

In case votes are tied, the person chairing the board meeting shall have a casting vote.

**Article 18** **Conflicts of interest**

In the event that a director has a direct or indirect interest of a proprietary nature that is opposed to that of a transaction on which the board of directors is called upon to pronounce or a decision that the board of directors is called upon to take, the rules and formalities provided by law shall apply. In such case, the conflicted director(s) shall be disregarded for the collation of the quorum and the votes. In case all directors or all but one director have such conflict of interest, the relevant decision or transaction should be submitted to the general meeting of shareholders. In case of approval by the general meeting of shareholders', the decision or transaction can be implemented by the board of directors.

**Article 19** **Powers of the board of directors – Daily management**

The board of directors is empowered with the most extensive powers to perform all acts necessary or useful to achieve the company's purpose, with the exception of those reserved by law or the articles of association to the general shareholders' meeting.

The board of directors is authorised to delegate the day-to-day management of the company and the representation as far as such management is concerned to one or more persons, directors or not. In case these persons are directors, they are called "managing directors". In case the daily management of the company is delegated to more than one person, these persons will form a collegial organ.

Unless the board of directors decides otherwise, the mandate of a person in charge with daily management is deemed not to be remunerated. The restrictions provided for in Article 7:121 juncto 7:91 of the Code of Companies and Associations shall not apply to persons entrusted with daily management, nor to any other leading persons the company in respect of any persons, for all persons falling within the scope of these as meant in Article 3:6 §3 the Code of Companies and Associations.

The board of directors can delegate a part of its powers to one or more persons who need not to be directors. It will determine their powers and remuneration. It can dismiss them and, if necessary, replace them.

The persons in charge of the daily management can give special proxies to any agent within the limits of their own powers.

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*English translation, for information purposes only*

The board of directors can draw up internal rules.

**Article 20** **Committees of the board of directors**

The board of directors shall have the power and, to the extent required by applicable law, the obligation to establish, one or more advisory committees in its midst and under its responsibility, such as (but not limited to) an audit committee, a nomination committee and a remuneration committee (which can be combined with the nomination committee).

The board of directors determines the composition and the missions of these committees and may draw up their terms of reference.

**Article 21** **Minutes**

The board resolutions are recorded in minutes, which are kept at the registered office of the company, and are signed by the director that chaired the meeting and the directors that wish to do so..

Copies or extracts of the minutes, to be produced in court or elsewhere, are signed by the chairperson of the board of directors, by two directors, or as the case may be, by any person(s) to whom daily management powers have been delegated, or by a special proxy holder.

**Article 22** **representation of the company**

Notwithstanding the general powers of representation of the board of directors as a collegial body, the company shall be validly represented, for all deeds and acts, including those involving a public or ministerial official as well as before a court, as claimant or defendant:

- by two directors, acting jointly;

- within the scope of the daily management, by any person to whom such daily management has been delegated, and should the daily management by exercised by a collegial organ, by two of its members;

- by any other person acting within the mandate granted to such person by the board of directors or a person in charge of the daily management.

Third parties cannot demand a prior decision of the board of directors as proof of the special powers of representation of these persons.

**Article 23** **Audit**

The financial position, the annual financial statements and the compliance of the transactions to be reflected in the annual financial statements, pursuant to the law and the articles of association shall be audited by one or more statutory auditors. The statutory auditors are appointed among the members of the Institute of Certified Auditors (*Institut des Réviseurs d'Entreprises*/*Instituut der Bedrijfsrevisoren*). The statutory auditors are appointed and remunerated in accordance with the relevant legal provisions.

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*English translation, for information purposes only*

The general meeting shall determine the number of auditors and fix their emoluments. In case more than one auditor has been appointed, they will act as a collegial body. They may divide their audit duties between them.

The appointment of retiring auditors which have not been re-appointed shall terminate after the closing of the annual shareholders' meeting.

**TITLE IV. General shareholders' meeting**

**Article 24** **Meeting**

The annual shareholders' meeting is held on the second Wednesday of the month of June, at 2:00 p.m. CET. Should this day be a public holiday, even if it is only a public holiday in one of the communities of Belgium, the meeting shall take place on the next working day at the same time, not including Saturday or Sunday.

The annual, special and extraordinary general shareholders' meetings are held at the place and time indicated in the convening notices. They can be held at a different place in Belgium than at the registered office of the company.

One or more shareholders holding at least ten (10) % of the company's capital may, in accordance with the Code of Companies and Associations, request that a general shareholders' meeting be held in order to submit one or more proposals. Notices shall be sent within the time limits and in accordance with the provisions of the Code of Companies and Associations.

One or more shareholders holding at least three (3) % of the company's capital may, in accordance with the Code of Companies and Associations, request the inclusion of items on the agenda of any general shareholders' meeting and submit proposals for resolutions on the items included or to be included on the agenda.

**Article 25** **Convening notices**

General shareholders' meetings shall be convened in accordance with the relevant legal provisions. The convening notice shall contain the agenda for the meeting, as well as the information required by applicable law.

The convening notices drafted by the board of directors can be validly signed in its name by a person to whom the daily management of the company has been delegated.

The persons participating in or represented at a general shareholders' meeting are considered to have been validly convened. They can also, before or after the general shareholders' meeting that they did not attend, waive the convening notice, or any irregularity in the convening notice, in writing.

The convening notices are assumed to be given on the day they are sent out.

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*English translation, for information purposes only*

**Article 26** **Admission to the general shareholders' meeting**

The right to participate in a general shareholders' meeting and to vote is only granted based on an accounting registration of the shares on the name of the shareholder, on the fourteenth (14th) day before the general shareholders' meeting, at midnight (CET), either by their registration in the register of registered shares of the company, or by their registration on the accounts of a recognized account holder or of a clearing institution, irrespective of the number of shares the shareholder possesses at the day of the general shareholders' meeting.

The day and time referred to in the first paragraph of this article form the record date.

The shareholder notifies the company, or the person appointed by the company for this purpose, ultimately on the sixth (6<sup>th</sup>) day before the date of the general shareholders' meeting, that he wants to participate in the general shareholders' meeting. The recognized account holder or the clearing institution provides the shareholder with a certificate evidencing the number of dematerialized shares registered in the shareholder's name on his accounts on the record date, for which the shareholder has indicated his desire to participate in the general shareholders' meeting.

In a register designated by the board of directors, the name and address or registered office of each shareholder who has notified the company of its intention to participate in the general shareholders' meeting are noted, as well as the number of shares he or she possessed on the record date and for which he or she has indicated to be participating in the general shareholders' meeting, and the description of the documents demonstrating that he or she was in possession of the shares on said record date.

The holders of profit sharing certificates (*parts bénéficiaires/winstbewijzen*), non-voting shares, bonds, warrants or other securities issued by the company, as well as the holders of certificates issued with the collaboration of the company and representing securities issued by the company (if any such exist), may attend the general shareholders' meeting with advisory vote insofar permitted by law. They may only participate in the vote in the cases determined by law. They are in any event subject to the same formalities as those imposed on the shareholders with respect to notice of attendance and admission, and the form and submission of proxies.

**Article 27** **Representation**

Each shareholder who is entitled to participate in the general shareholders' meeting, can be represented at said general shareholders' meeting by a proxy holder who has been granted a written proxy. Such proxies must be granted in accordance with the applicable law and/or as set out (in accordance with the applicable law) in the convening notice, as the case may be.

The holders of a proxy must comply with the relevant legal provisions concerning proxies for general shareholders' meetings, as relevant. In particular, the proxy must be signed by the shareholder and be sent to the company's e-mail address or the e-mail address specifically indicated in the notice of the meeting, at the latest six (6) days before the general shareholders' meeting.

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*English translation, for information purposes only*

The board of directors can establish a template for the proxies and make them available to the security holders.

**Article 28** **Bureau**

Each general shareholders' meeting shall be chaired by the chairperson of the board of directors, or, in case he or she is absent or hindered, a vice-chairperson of the board of directors, if any, or, in the absence of the latter, a director appointed by the board of directors or its chairperson, or in the absence of such appointment, by another director present or another person appointed by the directors present.

Unless otherwise decided by the shareholders present and represented at the general shareholders' meeting, the chairperson will appoint a secretary, who does not need to be a shareholder or a proxyholder of a shareholder.

In the event the number of participants in the general shareholders' meeting so requires, the chairperson of the general shareholders' meeting will appoint one or more tellers from among the shareholders or their proxy holders.

The chairperson of the general shareholders' meeting, the secretary and the tellers, if any, together make up the bureau of the general shareholders' meeting.

The chairperson can assemble the bureau prior to the general shareholders' meeting and, as such, the assembled bureau can proceed with the verification of the proxies granted to the participants of the general shareholders' meeting prior to the opening of the meeting.

**Article 29** **Number of votes**

Each share carries one vote, without prejudice to the cases in which the voting rights are suspended pursuant to these articles of association, the Code of Companies and Associations or any other applicable legislation.

**Article 30** **Remote votinG BEFORE THE GENERAL MEETING**

When provided for in the convocation notice to the general meeting, shareholders shall be authorised to vote remotely, by correspondence or via the company's website, using a form prepared and provided by the company. This form must indicate the date and place of the general shareholders' meeting, the shareholder's name, domicile or registered office, the number of votes which the shareholder wishes to cast at the general shareholders' meeting, the type of shares held and the items on the agenda for the meeting (including proposed resolutions) and include a space allowing the shareholder to vote for or against each resolution or to abstain as well as the deadline by which the voting form must reach the company. It shall expressly stipulate that the form must be signed and reach the company no later than the sixth (6<sup>th</sup>) day prior to the general shareholders' meeting. Digital votes via the company's website can be cast up to the day prior to the general meeting.

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*English translation, for information purposes only*

**Article 31** **Deliberations**

The general shareholders' meeting cannot deliberate on items that are not mentioned in the agenda, unless all shareholders are present or represented at the meeting and they unanimously decide to deliberate on these items.

Except when otherwise provided for by legal provisions or by the articles of association, the resolutions are taken by simple majority of the votes cast, irrespective of the number of shares represented at the general shareholders' meeting, except in the cases the law prescribes an attendance quorum. Blank and invalid votes are not taken into account to determine the votes cast.

The articles of association may only be amended by a majority of at least three quarters of the votes cast or, for amendments to the purpose of the company, four fifths of the votes cast, excluding abstentions.

The votes cast during the general shareholders' meeting are taken by raising hands or by calling off names, unless the general shareholders' shareholders' meeting decides otherwise by simple majority of the votes cast.

An attendance list indicating the names of the shareholders and the number of shares held by each shall be signed by each shareholder or his or her proxyholder before entering the general shareholders' meeting.

**Article 32** **ADJOURNMENTS**

Without prejudice to the right to adjourn pursuant to the applicable legal provisions, the board of directors has the right to adjourn the deliberations of each annual general meeting by five (5) weeks, even during the meeting itself.

**Article 33** **Minutes**

The minutes of the general shareholders' meeting shall be signed by the members of the bureau and by those shareholders who ask to do so.

The minutes of the general shareholders' meeting shall mention for each resolution the number of shares for which votes have been cast validly, the percentage of the capital represented by these shares, the total number of votes validly cast, and the number of votes cast in favour of against each resolution, as well as the number of abstentions, if any. The company shall publish this information on its website within fifteen (15) calendar days after the general shareholders' meeting.

Copies or extracts from the **minutes are** signed by two directors, acting jointly, or by a managing director.

**Article 34** **Remote participation**

If so provided in the convening notice for the general shareholders' meeting, each holder of shares, convertible bonds, warrants or certificates issued with the collaboration of the company can participate remotely to the general shareholders' meeting via electronic means of communication made available by the company, unless applicable law does not permit it.

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*English translation, for information purposes only*

As far as compliance with quorum and majority requirements is concerned, those who participate in this way to the general shareholders' meeting are considered to be present at the place where the meeting is held.

The aforementioned electronic means of communication must enable the company to verify the capacity and identity of the holder of the securities. The modalities to verify the capacity and identity of the person wishing to participate remotely are determined by the board of directors.

The holder of securities that wants to make use of this should at least be able to follow the deliberations directly, simultaneously and continuously during the general shareholders' meeting and shareholders need to be able cast their vote on each item on which the meeting needs to express itself.

**TITLE V. Accounting year – Distributions of profits – (Interim) dividends**

**Article 35** **Accounting year**

The financial year starts on the first (1) of January and ends on the thirty-first (31) of December each year.

At the end of each financial year the board of directors draws up an inventory as well as the annual accounts.

To the extent required by law, the directors also draw up an annual report in which they account for their management. This report contains a comment on the annual accounts in which a true overview is given of the operations and of the position of the company, as well as the information prescribed by the Code of Companies and Associations.

**Article 36** **Distribution of profits**

The net profits of the financial year are distributed in accordance with the applicable legal provisions.

Five (5) percent of the company's net profit is deducted each year to form a legal reserve. Once this legal reserve amounts to one tenth (1/10<sup>th</sup>) of the capital, such deduction is no longer required.

The general shareholders' meeting allocates the balance of the net profit by a simple majority of the votes upon the proposal of the board of directors.

**Article 37** **Interim dividend**

The board of directors can, at its own responsibility, declare the payment of interim dividends, in the cases and within the time limits provided by law.

**Article 38** **Dividends**

The dividends will be paid at the times and places as determined by the board of directors. All dividends not claimed within five years are time-barred and remain acquired by the company. They will be allocated to the legal reserve.

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*English translation, for information purposes only*

**TITLE VI. Dissolution and liquidation**

**Article 39** **Appointment and powers of liquidators**

If the company is wound up, for any reason and at any time whatsoever, liquidation shall be carried out by a liquidator or liquidators appointed by the general shareholders' meeting.

If it appears from the report summarising the company's assets and liabilities prepared in accordance with the Code of Companies and Associations that all creditors cannot be satisfied in full, the appointment of the liquidator(s) in the articles of association or by the general shareholders' meeting must be submitted to the president of the business court, unless it appears from this summary that the company only has debts to its shareholders and all shareholders who are creditors of the company confirm in writing their agreement with the appointment.

**In** the absence of the appointment of a liquidator or liquidators, the members of the board of directors shall be considered, by operation of law, as liquidators with regard to third parties, without however possessing the powers which the law and the articles of association grant to the liquidator appointed in the articles, by law or by the court, with respect to liquidation transactions.

The general shareholders' meeting shall determine the liquidators' fees, where appropriate.

The company's liquidation shall be concluded in accordance with the provisions of the Code of Companies and Associations.

**Article 40** **Allocation of the liquidation proceeds**

Following settlement of all debts, charges and costs of the liquidation, the net assets are first used to pay back, in cash or in kind, the fully paid-up and not yet paid back amount of the shares.

The balance, as the case may be, is divided in equal parts among all shares.

If the net proceeds are not sufficient to pay back all shares, the liquidators will first pay back these shares that are paid-up to a higher extent until they are at a level equal to the shares that are paid-up to a lesser extent, or they call for an additional paying-up of capital for the latter shares.

**TITLE VII. General provisions**

**Article 41** **Election of domicile**

Any holder of registered securities domiciled abroad shall be required to elect domicile in Belgium for all matters relating to the execution of these articles of association. In the absence of such an election of domicile, he or she is deemed to have elected domicile at the registered office of the company, where all notifications, notices and summonses and convocations can be validly served upon them.

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*English translation, for information purposes only*

Holders of registered shares must notify the company of any change of domicile. In the absence of such a notification, all communications, convocations or notifications will be validly made at their last known address.

The directors, the persons in charge of the daily management, the auditors and the liquidators, domiciled abroad, shall be deemed, throughout their term of office, to have elected domicile at the registered office of the company at which all judicial acts are validly sent to them.

Each director, person in charge of the daily management, auditor or liquidator may elect domicile at the registered office of the company for all matters relating to the exercise of their mandate. This election of domicile is enforceable against third parties in accordance with the legal provisions.

**Article 42** **Choice of forum**

All disputes relating to corporate matters and the implementation of these articles of association between the company, its shareholders, holders of bonds, holders of warrants, or holders of other securities or certificates issued by or with the cooperation of the company, its directors, statutory auditors, or liquidators, shall be subject to the exclusive jurisdiction of the courts of the jurisdiction of the registered office of the company, unless otherwise determined by the applicable law.

**Article 43** **Common law**

Any provisions of these articles of association that are contrary to any other applicable legislation shall be considered null and void. The invalidity of an article or part of an article in these articles of association shall have no effect on the validity of the remaining provisions (or parts thereof).

**Article 44** **Applicable law**

For all matters that are not expressly regulated in these articles of association, or for the legal provisions from which would not be deviated validly in these articles of association, the provisions of the Code of Companies and Associations and the other provisions of Belgian law apply.

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## Exhibit 4.17

**Exhibit 4.17**

*English translation – for information purposes only*

**NYXOAH SA**

Rue Edouard Belin 12

B-1435 Mont-Saint-Guibert

VAT: BE 0817.149.675

Register of legal entities of Walloon Brabant

(hereinafter the "**Company**")

**2025-2 WARRANTS PLAN**

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| | |
|:---|:---|
| **1** | **DEFINITIONS** |

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For the purposes of this Plan, the following terms shall have the following meaning:

"**Articles of Association**" means the articles of association of the Company.

"**Beneficiary**" means a person duly designated by a Holder who is a physical person, be it his/her spouse or his/her legal heirs, to exercise the rights of the Holder under this Plan after the decease of the Holder. Designation, revocation and re-designation of a Beneficiary shall be done in writing. In the absence of any valid designation, the heirs of the Holder will, in accordance with the applicable laws of inheritance, be deemed to be the Beneficiary. In case there are several heirs, all heirs acting jointly, or a person designated by all heirs acting jointly, will be deemed to be the Beneficiary.

"**Board of Directors**" means the board of directors of the Company.

"**Change of Control**" means any change of Control of the Person concerned, including (i) the loss of the exclusive Control, (ii) the loss of one or more of the (three) criteria used in the definition of Control, (iii) in case of common Control, the loss of common Control or the modification of the shareholders of the common Control, including the replacement of any Person holding the common Control, (iv) in case of succession of a Person being a physical person, the change of Control from such Person to the heirs thereof, (v) in case of nomination of a guardian, provisional administrator or similar act on a Person, being a physical person, the change of Control from such Person to the guardian or administrator thereof; provided, however, that a Change of Control does not include a change of Control resulting from a person acquiring securities which are quoted on an internationally recognised stock exchange.

"**Company**" means Nyxoah SA, a company limited by shares subject to Belgian law ("*société anonyme*"), with registered office at Rue Edouard Belin 12, 1435 Mont-Saint-Guibert, Belgium and registered with the Register of Legal Entities (Brabant wallon) under number 0817.149.675.

"**Company Secretary**" means the person who has been designated as company secretary by the Board of Directors from time to time.

"**Control**" and any derivation thereof, means with respect to any Person, the holding by any other Person, directly or indirectly, of (i) the majority of the outstanding voting interests in the Person concerned, (ii) the power, by contract or otherwise, to exercise, legally or factually, a determining influence on the appointment or dismissal of the majority of the directors, trustees, general partners or other governing body as applicable, in the Person, or (iii) the power, by contract or otherwise, to exercise, legally or factually, a determining influence on the orientation of the Person's management.

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*English translation – for information purposes only*

"**Controller**" has the meaning as set out in Clause 8.1.

"**Controlling Shareholder**" has the meaning as set out in Clause 7.

"**Deemed Liquidation Event**" means (i) sale, lease transfer, exclusive license or other disposition of all or substantially all of the Company's assets (including for the avoidance of doubt the material intellectual property rights of the Company and its Subsidiaries (if any)) or Shares, in a single transaction or series of related transactions, (ii) transaction or series of transactions resulting in a Change of Control over the shareholding of the Company (meaning a transaction as a result of which a third party acquires the exclusive Control over the Company), or (iii) merger, reverse merger or consolidation (with or into another entity) in which outstanding Shares of the Company or another Group Company are exchanged for securities or other consideration issued, or caused to be issued, by the acquiring company or a Subsidiary of the acquiring company and in which the shareholders of the Company immediately prior to the transaction do not own a majority of the shares of the surviving entity.

"**Eligible Warrants**" has the meaning as set out in Clause 7.

"**End of Mandate**" means the effective date of the termination, for whatsoever reason, of (i) the employment contract between the concerned Holder and any Group Company, (ii) the director's mandate exercised by the concerned Holder in any Group Company, or (iii) the services or other collaboration agreement between the concerned Holder and any Group Company. Such termination will not imply the "End of Mandate", however, if the termination of the relationship with the concerned Group Company is accompanied by the simultaneous entering into of an employment agreement with another Group Company, by the simultaneous appointment as a director of another Group Company, or by the simultaneous entering into of a services or other collaboration agreement with another Group Company.

"**Exercise Period**" means any of the periods during which, in accordance with Clause 6.2 of this Plan, the Holder can exercise Warrants granted to him/her so as to obtain Shares.

"**Final Exercise Date**" means the last day of the last Exercise Period of the relevant Warrants.

"**Grant**" means the grant of Warrants decided by the Board of Directors (or by the shareholders' meeting of the Company for grants of Warrants to directors of the Company as remuneration for their mandate as director).

"**Group Companies**" means the Company and its Subsidiaries from time to time and "**Group Company**" means any of them.

"**Holder**" means a physical person or a legal entity to whom the Company has offered Warrants and who/that has completely or partially accepted these Warrants.

"**Israeli Participant**" has the meaning as set out in Clause 7.

"**ITA**" has the meaning as set out in Clause 7.

"**Liquidation Event**" means a liquidation, dissolution, winding up or bankruptcy of the Company.

"**Offer**" has the meaning as set out in Clause 3.

"**Ordinance**" has the meaning as set out in Clause 7.

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"**Person**" means any physical person, corporation, general partnership, limited partnership, limited liability company, proprietorship, investment fund, other business organisation, trust, union or association.

"**Personal Data**" has the meaning as set out in Clause 8.2.

"**Plan**" means this 2025-2 Warrants Plan regarding warrants issued by the Company.

"**Processor**" has the meaning as set out in Clause 8.4.

"**Rules**" has the meaning as set out in Clause 7.

"**Share**" means any common share in the Company.

"**Subsidiary**" has the meaning as set out in Article 1:15 of the Code of Companies and Associations.

"**Trustee**" has the meaning as set out in Clause 7.

"**Warrant**" means a subscription right regarding a newly to be issued Share, issued and granted on the basis of this Plan.

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|:---|:---|
| **2** | **OBJECT AND PURPOSE OF THE PLAN** |

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Each Warrant shall entitle its Holder to subscribe for one (1) Share upon exercise of the Warrant, under the terms and conditions set out in this Plan.

In the framework of this Plan no more than seven hundred sixty thousand (760,000) Warrants can be issued. Consequently, the Company can issue up to seven hundred sixty thousand (760,000) Shares as a result of the exercise of the Warrants.

The purpose of this Plan is to advance the interests of the Company and its shareholders by enhancing the Group Companies' ability to attract, retain and motivate persons who make (or are expected to make) important contributions to the Company or any other Group Company by providing such persons with equity ownership opportunities and performance-based incentives and thereby better aligning the interests of such persons with those of the Company and its shareholders.

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|:---|:---|
| **3** | **GRANTING AND ACCEPTANCE OF THE WARRANTS** |

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The Warrants can be granted to any Persons who are employees, officers, directors, consultants and advisors of any Group Company and any Persons who have accepted an offer for employment or to provide professional services to a Group Company. The Warrants are granted by the Board of Directors, except for grants of Warrants to directors of the Company as remuneration for their mandate as director which must be approved by the shareholders' meeting.

The total number of Holders shall, in any event, be lower than one hundred fifty (150).

Each individual offer of Warrants shall be dated and notified in writing to the potential Holder (the "**Offer**"). Each physical person or legal entity to whom the Company has made an Offer has the possibility to accept or to refuse the Offer. The acceptance of Warrants needs to be done in writing by checking the option acceptance, and mentioning the number of accepted Warrants, on the answer form prepared for these purposes. Unless the Offer mentions otherwise, the answer form must be completed and signed by the potential

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*English translation – for information purposes only*

Holder and be delivered to the Company within sixty (60) days after the date of the Offer. If the potential Holder does not accept in writing the Offer of Warrants prior to the ultimate date stated in the answer form, he/she is deemed to have refused the Offer.

Notwithstanding the foregoing, the offering and acceptance of Warrants may also be included in a specific warrant agreement, or inserted in another agreement signed by the Company and the Holder.

Warrants that have been granted but that are refused by the potential Holder or that are not timely accepted in writing, shall not be null and void and can be offered again.

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| | |
|:---|:---|
| **4** | **TERMS AND CONDITIONS OF THE WARRANTS** |

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**4.1** **Warrant price** 

The Warrants shall be granted by the Company free of charge.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**4.2** **Vesting** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.2.1 At the time of the Grant, the Board of Directors (or the shareholders' meeting of the Company for grants of Warrants to directors of the Company as remuneration for their mandate as director) may freely decide if, when and to which extent the attributed Warrants will effectively vest for the Holders.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.2.2 Except as explicitly provided otherwise in this Plan and unless the Board of Directors (or the shareholders' meeting of the Company for grants of Warrants to directors of the Company as remuneration for their mandate as director) decides otherwise at the time of the Grant of the Warrants and subject to the End of Mandate (i) one fourth of the Warrants granted to and accepted by a Holder (whereby fractions of Warrants shall be rounded down) shall be deemed definitively vested on the date of the Offer of the Warrants, (ii) one fourth of the Warrants granted to and accepted by a Holder (whereby fractions of Warrants shall be rounded down) shall be deemed definitively vested on the first anniversary of the date of the Offer of the relevant Warrants, (iii) one fourth of the Warrants granted to and accepted by a Holder (whereby fractions of Warrants shall be rounded down) shall be deemed definitively vested on the second anniversary of the date of the Offer of the relevant Warrants, and (iv) the remainder of the Warrants granted to and accepted by a Holder shall be deemed definitively vested on the third anniversary of the date of the Offer of the relevant Warrants.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.2.3 The Board of Directors (subject to the approval by the shareholders' meeting of the Company regarding any Warrants granted to directors of the Company as remuneration for their mandate as director) can also decide to modify the vesting conditions after the Grant of Warrants, provided that the rights of the Holder may not be restricted without the latter's consent. Prior to the End of Mandate, the Board of Directors will, for example, in mutual agreement with the Holder, be able to allow that all or a part of the Warrants that have not yet definitively vested at the End of Mandate, are definitively vested.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**4.3** **Exercise price** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.3.1 Unless the Board of Directors (or the shareholders' meeting of the Company for grants of Warrants to directors of the Company as remuneration for their mandate as director) (x) at the time of the Grant of the Warrant determines a lower or higher exercise price or (y) after the time of the Grant lowers or increases the exercise price

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*English translation – for information purposes only*

as previously set (subject to approval by the relevant Holder), the exercise price of a Warrant will be equal to the lowest of the following prices:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the (counter value in euro of the) last closing price of the Company's Share, on the stock exchange where the Company's shares are (first) listed, prior to the date of the Offer; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the (counter value in euro of the) average closing price of the Company's Share, on the stock exchange where the Company's shares are (first) listed, over the thirty (30) day period preceding the date of the Offer.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.3.2 Upon exercise, EUR 0.01 of the exercise price needs to be recorded as capital. The portion of the exercise price exceeding EUR 0.01 needs to be recorded on a separate account unavailable for distribution called "Issuance premiums".

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**4.4** **Duration of the Warrants** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.4.1 The Warrants have a duration of ten (10) years as from the date of the meeting of the Board of Directors deciding on the issuance of the Warrants.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.4.2 Any Warrant shall immediately become automatically null and void if not exercised in accordance with the modalities provided for in this Plan (i) within ten (10) years after the date of the issuance of the Warrant, (ii) prior to a bankruptcy of the Company, (iii) in case of a Liquidation Event other than bankruptcy, prior to the effective date of such Liquidation Event, or (iv) in case of a Deemed Liquidation Event, prior to the completion of such Deemed Liquidation Event, unless the Board of Directors (or the shareholders' meeting of the Company for grants of Warrants to directors of the Company as remuneration for their mandate as director), at the time or (subject to approval of the relevant Holder) after the time of the Grant of the Warrants, decides that the relevant Warrants shall immediately become automatically null and void if not exercised in accordance with the modalities provided for in this Plan prior to an earlier date.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**4.5** **Nature** 

The Warrants are and will remain registered. They will be recorded in the register of warrant holders, which will be kept by the Company at the registered office, mentioning the identity of each Holder and the number of Warrants held by such Holder.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**4.6** **Adjustments** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.6.1 Modification of the Company's capital structure

Contrary to Article 7:71 of the Code of Companies and Associations and without prejudice to the exceptions provided for by law, the Company shall retain the right to take decisions and close transactions that could have an influence on its capital, the distribution of profit or the liquidation bonuses, or that could possibly have another influence on the Holders' rights, except if such decisions or transactions only are aimed at diminishing the Holders' benefits.

In case the rights of the Holder are affected by such decision or transaction, the Holder will not be entitled to a modification of the exercise price or the exercise conditions, nor to any other form of financial or other compensation. The Board of Directors may, however, at its own discretion, make amendments to the number of Shares to which one Warrant relates and/or to the exercise price to compensate any

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such adverse effect for the Holder in full or in part. As soon as reasonably possible, the Company will inform the Holder of any such amendment by way of a written notification.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.6.2 Reorganizations of Shares

In the event that the Company shall (i) sub-divide its Shares into a larger number of Shares, (ii) combine its Shares into a smaller number of Shares, (iii) increase or decrease the number of Shares by a reclassification of Shares (without an increase or decrease of the Company's share capital), then the number of Shares to be issued upon exercise of the Warrant after the occurrence of one of such events shall be adjusted (if and to the extent required) so that, after giving effect to such adjustment, the Holder of the Warrant shall be entitled to receive the number of Shares upon exercise of the Warrant that such Holder would have owned or have been entitled to receive had this Warrant been exercised immediately prior to the occurrence of the event concerned. An adjustment made pursuant to this Clause 4.6.2 shall become effective immediately after the effective date of the event concerned. The Company shall inform the Holders of such adjustment by means of a notice as soon as practicable after the effective date of the event concerned.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.6.3 Mergers, de-mergers

In the event that there shall be (i) a merger ("*fusion*") of the Company with or into another person or entity whereby the Company is not the surviving entity, or (ii) a de-merger ("*scission*") of the Company, whereby in both (i) and (ii) the Shares of the Company are exchanged into shares, other securities, cash or other property of one or more other persons, then the Shares to be issued upon exercise of the Warrant after the occurrence of one of such events shall be adjusted (if and to the extent required) so that, after giving effect to such adjustment, the Holder of the Warrant shall upon exercise of the Warrant be entitled to receive the number of shares, other securities, cash or other property of the successor or acquiring persons that such Holder would have owned or have been entitled to receive had this Warrant been exercised immediately prior to the occurrence of the event concerned. An adjustment made pursuant to this Clause 4.6.3 shall become effective immediately after the effective date of the event concerned. The Company shall inform the Holders of such adjustment by means of a notice as soon as practicable after the effective date of the event concerned.

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| **5** | **END OF MANDATE - TRANSFER OF THE WARRANTS - ADJUSTMENTS** |

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**5.1** **End of Mandate** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.1.1 Unless the Board of Directors (or the shareholders' meeting of the Company for grants of Warrants to directors of the Company as remuneration for their mandate as director) decides otherwise at the time of the Grant, at the End of Mandate of a Holder:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) all Warrants that have been granted to such Holder but have not yet vested in accordance with this Plan, shall become automatically null and void, unless, prior to the End of Mandate, it is expressly agreed otherwise in writing between the Company and the Holder in accordance with Clause 4.2.3 of this Plan; and

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) all Warrants that have been granted to such Holder and have vested in accordance with this Plan, shall remain with such Holder for a period of three (3) months after the End of Mandate and all Warrants that are not exercised prior to the expiry of such three (3) months' period shall become automatically null and void, unless, prior to the End of Mandate, it is expressly agreed otherwise in writing between the Company and the Holder (subject to the approval by the shareholders' meeting of the Company regarding any Warrants granted to directors of the Company as remuneration for their mandate as director).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.1.2 Notwithstanding Clause 5.1.1 of this Plan, if the agreement or other relationship between the Holder and a Group Company is terminated for "cause", all unexercised Warrants (even those already vested) that have been granted to such Holder shall become automatically null and void at the End of Mandate of such Holder. For the purposes of this Clause 5.1.2, "cause" means wilful misconduct by the Holder or wilful failure by the Holder to perform his/her responsibilities to the Group Company (including, without limitation, breach by the Holder of any provision of any employment, consulting, advisory, non-disclosure, non-competition or other similar agreement between the Holder and the Group Company) as determined by the Company, which determination shall be conclusive. The Holder shall be considered to have been discharged for "cause" if the Company determines, within ninety (90) days after the Holder's resignation, that discharge for cause was warranted.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**5.2** **Member of the group** 

Unless the Board of Directors decides otherwise, all Warrants that have not yet vested in accordance with Clause 4.2 of this Plan shall become automatically null and void in case the company (other than the Company) of which the Holder is an employee, officer, director, consultant or advisor, is no longer Controlled by the Company.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**5.3** **Disability** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.3.1 If a Holder becomes fully disabled prior to the Final Exercise Date, all Warrants of the disabled Holder that have vested already in accordance with Clause 4.2 of this Plan prior to the date on which he/she became fully disabled shall immediately become exercisable until the first anniversary of the date on which the relevant Holder became fully disabled, unless the Board of Directors decides that such restriction shall not apply or decides a longer period (subject to the approval by the shareholders' meeting of the Company regarding any Warrants granted to directors of the Company as remuneration for their mandate as director). Unless the Board of Directors has decided to lift such restriction, all such Warrants that have not been exercised (or could not yet be exercised) in accordance with the modalities defined in this Plan prior to the first anniversary of the date on which the relevant Holder became fully disabled (or such later date as the Board of Directors has decided, as the case may be) shall become automatically null and void.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.3.2 Unless the Board of Directors decides otherwise (subject to the approval by the shareholders' meeting of the Company regarding any Warrants granted to directors of the Company as remuneration for their mandate as director), all Warrants that have not yet vested in accordance with Clause 4.2 of this Plan prior to the date on which the relevant Holder became fully disabled shall become automatically null and void.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**5.4** **Decease** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.4.1 If a Holder deceases prior to the Final Exercise Date, all Warrants of the deceased Holder that have vested already in accordance with Clause 4.2 of this Plan at the time of his/her decease, are transferred to the Beneficiaries of the Holder, and they shall immediately become exercisable until the first anniversary of the decease of the relevant Holder, unless the Board of Directors decides that such restriction shall not apply or decides a longer period (subject to the approval by the shareholders' meeting of the Company regarding any Warrants granted to directors of the Company as remuneration for their mandate as director). Unless the Board of Directors has decided to lift such restriction, all such Warrants that have not been exercised (or could not yet be exercised) in accordance with the modalities defined in this Plan prior to the first anniversary of the decease of the relevant Holder (or such later date as the Board of Directors has decided, as the case may be) shall become automatically null and void.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.4.2 Unless the Board of Directors decides otherwise (subject to the approval by the shareholders' meeting of the Company regarding any Warrants granted to directors of the Company as remuneration for their mandate as director), all Warrants that have not yet vested in accordance with Clause 4.2 of this Plan at the time of the decease of the Holder shall become automatically null and void.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**5.5** **Transferability** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.5.1 Unless the Board of Directors decides otherwise, the Warrants are not transferable *inter vivos* once they have been granted to a Holder, and may not be pledged or encumbered with any security, pledge or other right in rem in any other way, either voluntarily, by operation of law or otherwise.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.5.2 Unless the Board of Directors decides otherwise, Warrants that have been pledged or encumbered in violation of the preceding, shall become automatically null and void.

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|:---|:---|
| **6** | **EXERCISE OF THE WARRANTS** |

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**6.1** **General** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.1.1 The Warrants can only be exercised by the Holder if they have effectively vested pursuant to Clause 4.2 of this Plan and in accordance with any additional exercise restrictions (e.g., making the exercisability of the Warrants subject to specific conditions or limiting the duration during which the Warrants can be exercised) decided by the Board of Directors (or the shareholders' meeting of the Company for grants of Warrants to directors of the Company as remuneration for their mandate as director) at the time of the Grant. The Warrants that have become exercisable can only be exercised in accordance with the exercise modalities provided for in this Plan.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.1.2 In deviation of Article 7:71 of the Code of Companies and Associations, the Warrants cannot be exercised prematurely in case of a capital increase by way of contribution in cash, unless the Board of Directors (or the shareholders' meeting of the Company for grants of Warrants to directors of the Company as remuneration for their mandate as director) decides otherwise at the time of the Grant.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.1.3 In case the Warrants, that are not yet exercisable in accordance with the terms and conditions of the Plan, become prematurely exercisable in accordance with Article 7:71 of the Code of Companies and Associations (if so decided pursuant to Clause 6.1.2) and are effectively exercised in accordance with such Article, the Shares that are issued as a result of such exercise will not be transferable until the moment that the Warrants would have been exercisable pursuant to the terms and conditions of the Plan, unless express approval is obtained from the Company and without prejudice to any other applicable share transfer restrictions (including, but not limited to, those set out in the Articles of Association, as the case may be).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.1.4 In case Warrants that are effectively vested would not be exercised on the Final Exercise Date, such Warrants shall become automatically null and void.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**6.2** **Warrant Exercise Period** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.2.1 Without prejudice to Clause 6.1.1 of this Plan,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) Warrants may be exercised during the following periods:

- from 1 March until 30 June; and

- from 1 September until 30 November,

of each year during which, and for as long as, they are valid and exercisable; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) in the event of the End of Mandate of a Holder, such Holder can exercise his/her Warrants during a period of 3 months immediately following the End of Mandate, unless agreed otherwise between the Company and the relevant Holder pursuant to Clause 5.1.1(ii).

Within the legal boundaries, the Board of Directors can decide, at its discretion, to amend the Exercise Periods, however, without being able to shorten them. For example, in order to avoid insider trading, the Board of Directors can decide to introduce closed periods, during which the Warrants cannot be exercised. If such closed periods would fall within the aforementioned Exercise Periods, the Board of Directors can determine one or more additional Exercise Periods as compensation and communicate the new Exercise Periods in writing to the Holders.

Warrants cannot be exercised and/or the Shares cannot be traded in the event that the Holder has inside information. In accordance with article 7, paragraph 1, a) of Regulation (EU) No 596/2014 of the European Parliament and of the Council of 16 April 2014 on market abuse, "inside information" means information of a precise nature, which has not been made public, relating, directly or indirectly, to the Company or to one or more financial instruments issued by the Company, and which, if it were made public, would be likely to have a significant effect on the prices of those financial instruments or on the price of related derivative financial instruments.

Holders whose exercise rights are limited as a consequence of the conditions of this Plan or of any "Dealing Code" of the Company, are never entitled to any indemnification or compensation from the Company.

The exercise of the Warrants at the exercise price is unconditional.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.2.2 Liquidation Event or Deemed Liquidation Event

Notwithstanding Clauses 4.2, 6.1.1 and 6.2.1 of this Plan, and unless the Board of Directors (or the shareholders' meeting of the Company for grants of Warrants to directors of the Company as remuneration for their mandate as director) decides otherwise at the time of the Grant of the Warrants, the Warrants will immediately vest and be exercisable during at least ten (10) business days (i) prior to the effective date of a Liquidation Event other than bankruptcy, and (ii) prior to the completion of a Deemed Liquidation Event, it being understood that such vesting and exercise of the Warrants shall be conditional upon the effectiveness of such Liquidation Event or Deemed Liquidation Event. As the case may be, the provisions in the Articles of Association regarding pre-emption, tag-along and drag along rights shall apply.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**6.3** **Exercise restriction** 

The Board of Directors (or the shareholders' meeting of the Company for grants of Warrants to directors of the Company as remuneration for their mandate as director) may impose additional restrictions and conditions to the exercisability of the Warrants at the time or (subject to approval of the relevant Holder) after the time of the Grant of the Warrants.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**6.4** **Exercise modalities** 

In order to exercise a Warrant, at the latest on the Final Exercise Date, the Company needs to receive a written notice of exercise of the Warrants from the Holder (or, if applicable, his/her Beneficiaries). The notification shall take place by registered mail, against receipt confirmation, or by personal delivery or by email to the Board of Directors or the Company Secretary at the registered office of the Company. The notice must explicitly state the number of Warrants being exercised and the number of Shares consequently being subscribed to. If the Warrants are exercised by one or more Beneficiaries, the notice of exercise needs to be accompanied by an appropriate proof of the right of this person or these persons to exercise the Warrants.

The full amount of the exercise price of the exercised Warrants needs to be paid in cash and deposited by wire transfer on a blocked account of the Company of which the bank account number is communicated by the Board of Directors, the Company Secretary, or a delegate. Unless agreed otherwise by the Company, this payment shall take place within ten (10) business days after having received the aforementioned communication of the bank account number, or within ten (10) business days after the date of the notice of exercise in the event that the bank account number concerned has already previously been communicated by the Board of Directors.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**6.5** **Issuance of Shares** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.5.1 The Company will only be obliged to issue Shares as a result of the exercise of Warrants if such Shares are fully paid up and the other conditions set out in this Plan have been fulfilled.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.5.2 The Shares will be issued as soon as reasonably possible, taking into account administrative formalities, after the end of the Exercise Period during which the concerned Warrant was validly exercised or sooner if so decided by the Company. To this effect, the Board of Directors or one of the directors will acknowledge before a notary public that the capital was increased in accordance with Article 7:187 of the Code of Companies and Associations.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.5.3 The Shares that are issued as a result of the exercise of the Warrants will be common shares in the Company and will be fully profit sharing as from the beginning of the business year during which the Shares are issued and the following financial years.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.5.4 At the option of the Company, and to the extent legally and practically possible, the Shares shall be delivered as registered shares, or in dematerialised form. In case the Holder (or, as the case may be, the Holder's Beneficiary) explicitly indicates in his/her/its notice of exercise the form in which he/she/it wants to see the Shares delivered, the Company will deliver the Shares in the form requested to the extent legally and practically possible and to the extent that this would be in accordance with the Articles of Association. The Company will inform the concerned Holder (or, as the case may be, the Holder's Beneficiary) of the form of delivery in due time.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.5.5 After the issuance of the Shares in registered form, which are subscribed for through the exercise of Warrants, one or more directors of the Company or the Company Secretary will, as attorney-in-fact, register the Shares in the name of the subscriber in the Company's share register.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**6.6** **Rights as shareholders** 

The Holder or, as the case may be, the Holder's Beneficiary does not have any rights and privileges of a shareholder regarding the Shares, object of this Plan, until the date these Shares are effectively issued by the Company to the Holder or, as the case may be, the Holder's Beneficiary. Once the Shares have been issued by the Company to the Holder, the latter enjoys, in his capacity as shareholder, the same rights as the other shareholders in the Company, and such Shares shall be subject to the provisions of the Articles of Association (including but not limited to the share transfer restrictions).

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| **7** | **PROVISIONS REGARDING ISRAELI HOLDERS** |

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**7.1** Notwithstanding anything stipulated in the Plan, the following conditions shall take precedence over any provision of the Plan in relation to Holders who are employees, officers, directors, consultants and/or advisors ()"**Nosei Misra**" - as such term is defined in the Israeli Companies Law) of a Group Company residing and exercising their employment, mandate or function in Israel (hereinafter the "**Israeli Participant** ").

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**7.2** Warrants granted under the Plan to an Israeli Participant may contain such terms as will allow the Warrants and the Shares acquired pursuant to the exercise of such Warrants to be recognized (hereinafter "**Eligible Warrants**") pursuant to Section 102 of the Israel Income Tax Ordinance (New Version), as amended (the "**Ordinance**") and to comply with the Ordinance and its regulations and the Income Tax Rules (Tax Benefits in Share Issuances to Employees) 5363-2003 (the "**Rules** ").

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**7.3** Eligible Warrants, Warrants and/or Shares, as the case may be, shall be held in escrow for the benefit of such Israeli Participant by an Israeli trustee appointed by the Company to hold in trust, the Eligible Warrants, Warrants and/or the (underlying) Shares issued upon exercise of such Warrants, on behalf of Israeli Participant(s) (the "**Trustee** ").

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**7.4** **Application of section 102 of the Ordinance** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.4.1 Warrants and/or Shares, as the case may be, granted to Israeli Participants who are deemed to be a "**Controlling Shareholder** ", as such term is defined in Section 32(i) of the Ordinance, or any Israeli resident serving as a consultant of the Company or an Israeli resident affiliate of the Company, and who is not entitled to receive stock

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options under Section 102 of the Ordinance, shall be subject to Section 3(i) of the Ordinance, as shall apply from time to time. The Board of Directors shall have the absolute discretion to decide whether Warrants and/or Shares granted pursuant to Section 3(i) of the Ordinance shall be held with the Trustee.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.4.2 Warrants and/or Shares, as the case may be, may be granted under Section 102 of the Ordinance to an Israeli tax resident who is an employee or a director of the Company or an Israeli affiliate of the Company, on behalf of whom a stock option is granted under Section 102 of the Ordinance.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.4.3 The Trustee and each Israeli Participant in the Plan shall comply with the Ordinance and Rules and with the trust agreement entered into between the Company and the Trustee.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.4.4 Without derogating from the aforementioned, the Board of Directors shall have the authority to determine the specific procedures and conditions of the trusteeship with the Trustee in a separate agreement between the Company and the Trustee.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.4.5 The Eligible Warrants, Warrants and/or Shares, as the case may be, and any underlying rights, shall be issued to and held by the Trustee for the benefit of the Israeli Participant in accordance with the provisions of Section 102 of the Ordinance (under the tax route chosen by the Company) and the provisions of the Rules at least for the period required by the Ordinance and the Rules, or such other period as may be required by the Israeli Tax Authority ()"**ITA** "). All rights accruing out of and/or resulting from the Eligible Warrants, Warrants and/or Shares, as the case may, including, but not limited to bonus shares, shall be vested with the Trustee until the end of the holding period, if and to the extent prescribed by the Ordinance and/or the Rules.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.4.6 After the required holding period and subject to any further period included in this Plan, or the warrant agreement with the Israeli Participant, the Trustee may release the Eligible Warrants, Warrants and/or Shares, as the case may be to the Israeli Participant only after the receipt by the Trustee of an acknowledgment from the ITA that the Israeli Participant has paid or will pay any applicable tax due pursuant to the Ordinance and Rules.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.4.7 The validity of any order given to the Trustee by the Israeli Participant shall be subject to the approval of the Company. The Company shall render its decision regarding whether to approve orders given by any Israeli Participant to the Trustee within a reasonable period of time. The Company shall not be required to approve any order which is incomplete, is not in accordance with the provisions of this Plan and the relevant warrant agreement or which the Company believes should not be executed for any reasonable reason. The Company shall notify the Israeli Participant of the reason for not approving his order. Approval by the Company of any order given to the Trustee by an Israeli Participant shall not constitute proof of the Company's recognition of any right of such Trustee or such Israeli Participant.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.4.8 In the event a stock dividend and/or bonus shares are declared on the Eligible Warrants, Warrants and/or Shares, such dividend shares shall be subject to the provisions of this Plan and the holding period for such dividend shares shall be measured from the commencement of the holding period for the Eligible Warrants, Warrants and/or Shares, as the case may be, from which the dividend was declared.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.4.9 According to today's laws, the exemption under Section 102 of the Ordinance shall be forfeited and the Israeli Participant shall be required to pay any applicable tax promptly at such time as (i) the Company or the Israeli Participant fail to comply with one or more of the conditions for the exemption as required by the Ordinance, Rules or ITA; or (ii) the ITA withdraws or cancels the exemption for the Plan or for the particular Israeli Participant. Notwithstanding the loss of an exemption, the Trustee shall continue to hold the Eligible Warrants, Warrants and/or Shares, as the case may be (to the extent the Warrant remains exercisable following termination of employment) for the remainder of the applicable holding period under Section 102 of the Ordinance.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.4.10 Notwithstanding the aforesaid, an Israeli Participant shall not be entitled to the issuance or exercise of the Eligible Warrants, Warrants and/or Shares, including, but not limited to declared dividends and/or bonus shares, as the case may be, prior to the end of the holding period by the Trustee, in accordance with the tax route elected by the Company.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**7.5** All tax, duties and levies liabilities regarding the issue and/or exercise and/or the transfer, waiver, or expiration and/or the disposal of the Eligible Warrants, Warrants and/or Shares, including, but not limited to declared dividends and/or bonus shares, as the case may be, shall be borne by the Israeli Participant and in the event of death of such Israeli Participant, by his/her Beneficiaries, all in accordance with the tax route elected by the Company.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**7.6** Neither the Company nor any of its Subsidiaries nor the Trustee shall be required to bear the aforementioned taxes, duties and/or levies liabilities, directly or indirectly, nor shall they be required to gross up such taxes, duties and/or levies liabilities in the Israeli Participant's salaries or remuneration. The applicable taxes, duties and/or levies liabilities shall be deducted from the proceeds of disposal of the Eligible Warrants, Warrants and/or Shares or shall be paid to the Trustee or to the Company, as the case may be, by the Israeli Participant. The Company is also entitled to withhold taxes, duties and/or levies liabilities in accordance with relevant law, rules and regulations.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**7.7** Without derogating from the above, the Eligible Warrants, Warrants and/or Shares which are granted to Israeli Participants shall be subject to the provisions of Section 102 of the Ordinance, as shall apply from time to time, and the Rules promulgated thereunder. The Board of Directors shall have the absolute discretion to choose between any available tax routes to the Israeli Participant under Section 102 of the Ordinance, subject to the provisions of the Ordinance.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**7.8** The Israeli Participant shall agree and undertake to indemnify the Trustee and the Company and its Subsidiaries and hold each of them harmless against and from any taxes, duties and/or levies liability, including interest and/or fines of any type and/or linkage differentials in respect of such taxes, duties and/or levies liability and/or withheld tax and penalties thereon, which may be incurred as a result of the granting or exercise of an Eligible Warrant or the issuance of Shares pursuant to such Warrants.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**7.9** The Company's obligation to deliver Shares upon the exercise of Warrants is subject to payment (or provision of payment satisfactory to the Board of Directors) by the Israeli Participant of all taxes, duties and/or levies liability due under any applicable law.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**7.10** The ramifications of any future modification of any applicable law regarding the taxation of Eligible Warrants, Warrants and/or Shares granted to Israeli Participants shall apply to the Israeli Participants accordingly and such Israeli Participants shall bear the full cost thereof,

------

*English translation – for information purposes only*

unless such modified laws expressly provide otherwise. For the avoidance of doubt, should the applicability of such taxing arrangements to this Plan or to securities issued in the framework thereof be conditioned on an application by the Company or by the Trustee that same shall apply, the Company shall be entitled to decide, at its absolute discretion, whether to apply such taxing arrangements and to instruct the Trustee to act accordingly.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**7.11** During the required holding period, the Israeli Participant shall not release from trust or sell, assign, transfer or give as collateral, the Shares issuable upon the exercise or (if applicable) vesting of a 102 trustee award and/or any securities issued or distributed with respect thereto, until the expiration of the required holding period. Notwithstanding the above, if any such sale, release or other action occurs during the required holding period it may result in adverse tax consequences to the Israeli Participant under Section 102 of the Ordinance and the Rules, which shall apply to and shall be borne solely by such Israeli Participant.

---

| | |
|:---|:---|
| **8** | **PRIVACY AND PROCESSING OF PERSONAL DATA** |

---

To enable the proper set-up and management of the Plan and the (electronic) register of warrant holders and the (electronic) share register of the Company, information about each Holder will need to be collected and used. For Holders who are physical persons, this Clause 8 sets out the obligations of the Company and the rights of each of the Holders regarding this collection and use, and provides the legally required information in this respect.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**8.1** **Identity of the person responsible for Holders' Personal Data** 

The Company is the so-called "**Controller**", i.e. the person responsible for the collection and use of Personal Data as is necessary for the setting-up, implementation, administration and management of the Plan, the (electronic) register of warrant holders and the (electronic) share register of the Company.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**8.2** **Nature of the Personal Data** 

The following items of information relating to each of the Holders will be collected and used:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) identification data (e.g. name, contact details);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) electronic identification data;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) personal characteristics (e.g. date of birth, gender, nationality);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) employer's or contractor's identity;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) preferred language;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) financial data (e.g. bank account); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) details of all Warrants, underlying Shares and all other entitlement awarded, cancelled, purchased, vested, unvested or outstanding,

together the "**Personal Data**".

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**8.3** **Why and how Personal Data is collected and used** 

The Personal Data collected by way of the Company's HR systems, any Warrant agreement or acceptance form will be used exclusively for the purposes of the setting-up, implementation, administration and management of the Plan and the maintenance of the (electronic) register of warrant holders and (electronic) share register of the Company.

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*English translation – for information purposes only*

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**8.4** **Other persons having access to the Personal Data and purpose thereof** 

The Controller can transfer the Personal Data to the following categories of recipients:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) any service provider designated by the Controller to collect or use Personal Data on behalf of the Controller in accordance with this Clause 8 for the purposes of implementing, administrating and managing the Plan and, if applicable, the (electronic) register of warrant holders and (electronic) share register of the Company (the "**Processors** "); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) regulatory authorities for complying with legal obligations in connection with the Plan.

Such recipients may be located in jurisdictions outside the European Economic Area that offer an adequate level of personal data protection, in particular Israel. For the avoidance of doubt, Israel has been recognised by the European Commission as a country located outside the European Economic Area that does offer an adequate level of personal data protection.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**8.5** **Legal basis allowing the Company to collect and use Personal Data** 

With respect to the setting-up, implementation, administration and management of the Plan and the (electronic) register of warrant holders and (electronic) share register of the Company, the collection, processing and use of the Personal Data is necessary to perform the Company's contractual obligations towards the Holders. If the Personal Data of a Holder cannot be collected, processed or used, this Holder cannot participate in the Plan.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**8.6** **Rights of the Holders** 

The Holders can exercise their right to request access to and rectification or erasure of their Personal Data or restriction of processing concerning the Holders or to <u>object</u> to processing as well as the right to data portability by sending a written and signed request to the Company's registered office at Rue Edouard Belin 12, 1453 Mont-Saint-Guibert, Belgium, for the attention of the Company's Data Protection Officer or by email to privacy@nyxoah.com.

Finally, if Holders are not satisfied with how the Company processes their Personal Data, they can contact the Company's Data Protection Officer at Rue Edouard Belin 12, 1453 Mont-Saint-Guibert, Belgium, by email to privacy@nyxoah.com.

Holders also always have the right to make a complaint to the competent data protection authority in the EU Member State of their habitual residence, their place of work or of an alleged infringement of the applicable data protection rules.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**8.7** **Storage period of the Personal Data** 

Personal Data will be stored for a period of ten (10) years following the later of (i) the termination of the Plan or (ii) the end of a Holder's participation in the Plan.

---

| | |
|:---|:---|
| **9** | **MISCELLANEOUS** |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**9.1** **Amendments, suspension and termination of this Plan** 

The terms and conditions set out in this Plan may entirely or partially be amended, modified, suspended or terminated by the Board of Directors at any time. The amendment, suspension or termination of this Plan may not modify or limit the rights and obligations under a granted

------

*English translation – for information purposes only*

Warrant without the consent of the concerned Holder. No Warrant can be granted when this Plan is suspended or after the termination of this Plan.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**9.2** **National legislation** 

Notwithstanding any provision of the Plan, the Board of Directors may modify or extend the provisions of the Plan and the conditions of the Warrants to the extent that it considers this to be necessary or preferable to take into account, to limit the disadvantageous consequences of, or to be in compliance with foreign legislation, including, but not limited to, tax and financial legislation applicable to the Holder, to the extent that the terms and conditions of the Warrants granted to such Holder are not more advantageous than the terms and conditions of the Warrants granted to the other Holders.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**9.3** **Costs and taxes** 

The costs regarding the issuance of the Warrants and the capital increase relating to the issuance and exercise of the Warrants are borne by the Company.

Holders (or, if applicable, his/her Beneficiaries) will have to bear any taxes (including but not limited to stamp duties, registration duties and other indirect taxes, income taxes, capital gains taxes and stock exchange taxes) and employee or self-employed social security contributions due in connection with (a) the acceptance, exercise, and/or transfer of the Warrants and (b) the delivery, ownership and/or transfer of the new Shares, in accordance with applicable tax and social security legislation.

The Company or a Subsidiary shall levy any and all withholding taxes and social security contributions in relation to the Grant of the Warrants as provided for in the relevant applicable tax and/or social security laws.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**9.4** **Investment risk** 

An investment in Warrants or Shares involves substantial risks.

Before making an investment decision with respect to the acceptance and/or exercise of the Warrants, the Beneficiary / Holder should consider the risks and uncertainties with which the Company is or might be confronted (including but not limited to those mentioned in the annual reports of the Company) and read the annual accounts and annual reports of the Company. Past performances of the Company give no guarantees for the future.

It cannot be excluded that the market value of a Share during the entire duration of the Warrants will be lower than the applicable exercise price of a Warrant. The taxes and social security contributions that may be due in connection with the acceptance of the Warrants cannot be recovered, even if the Warrants expire without having been exercised. It can also not be excluded that the value of the Shares after exercise of Warrants will decrease and that the Holder loses all or part of his investment in Shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**9.5** **Employment conditions** 

No provision of this Plan can be construed as creating an obligation of employment (either by way of an employment agreement, an appointment as director or a services agreement) between a Group Company and a Holder or an obligation for the Board of Directors to offer Warrants. Upon termination of the employment, the Holder shall in no event be entitled to demand damages within the framework of this Plan. The foregoing also applies, but is not limited to, the application of the tax legislation.

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*English translation – for information purposes only*

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**9.6** **Nullity of a provision** 

The nullity or unenforceability of any provision of this Plan does not in any way affect the validity or enforceability of the remaining provisions of this Plan. In this case, the invalid or unenforceable provision will be replaced by an equivalent valid and enforceable provision having a similar economic effect for the parties concerned.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**9.7** **Applicable law** 

This Plan and any non-contractual obligations arising out of or in connection with it shall be governed by and construed in accordance with Belgian law.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**9.8** **Competent courts** 

The courts of Brussels (Belgium) have exclusive jurisdiction to settle any dispute arising out of or in connection with this Plan (including a dispute relating to non-contractual obligations arising out of or in connection with this Plan).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**9.9** **Notices** 

Any notice to the Holders (and, if applicable, his/her Beneficiaries) shall be validly made to the address mentioned in the register of warrant holders.

Any notice to the Company, shall be validly made to the attention of the Board of Directors or the Company Secretary at the address of the registered office of the Company.

Address modifications must be notified immediately by the Holders (and, if applicable, his/her Beneficiaries) to the Company in accordance with this provision.

\*\*

\*

Adopted by the Board of Directors on 13 October 2025.

On behalf of the Board of Directors

Olivier Taelman

Director

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## Exhibit 4.18

**Exhibit 4.18**

**STRICTLY PRIVATE AND CONFIDENTIAL**

To: Nyxoah SA<br>Rue Edouard Belin 12<br>1435 Mont-Saint-Guibert<br>Belgium

November 2025

Ladies and Gentlemen,

**Re:** **Subscription commitment to a capital increase**

This letter (the "**Subscription Commitment Letter**") is sent on behalf of [name investor], [an individual resident of [x]/[a company organised and existing under the laws of [x], with registered office at [x], and company number [x]] (hereinafter referred to as "**we**", "**us**", or the "**Undersigned**").

We understand that Nyxoah SA, a limited liability company (*société anonyme*) organised and existing under the laws of Belgium, with registered office at Rue Edouard Belin 12, 1435 Mont-Saint-Guibert, Belgium and registered with the Register of Legal Entities (Brabant wallon) under number 0817.149.675 (the "**Company**"), intends to raise between EUR [x] million (the "**Minimum Capital Increase Amount**") and EUR [x] million by way of a capital increase in cash (the "**Capital Increase**"), following a private placement of new ordinary shares with a limited number of investors (the "**Private Placement**").

The total share capital of the Company prior to the Private Placement amounts to EUR 6,449,871.98, represented by 37,544,782 shares.

The Private Placement is scheduled to be announced on or about the date hereof, subject to the Company having received subscription commitments in respect of the totality of the Minimum Capital Increase Amount from the Undersigned and certain other investors (including, as the case may be, existing shareholders, directors and officers of the Company).

Against the above background, for the benefit of the Company, we confirm the following:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. We irrevocably undertake to subscribe and pay for new ordinary shares of the Company (the "**New Shares**") for an aggregated amount of EUR [x] (the "**Subscription Commitment Amount** "), at a subscription price per New Share equal to EUR [x], such undertaking being referred to as the "**Subscription Commitment"**).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. For purposes of implementing the Capital Increase, we undertake:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) to pay the Subscription Commitment Amount by not later than [date], 2025 to the blocked bank account in the name of the Company with number IBAN [x] ([Belfius Bank - SWIFT GKCCBEBB]);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) to sign such documents as necessary or useful for purposes of subscribing to the New Shares and enacting the Capital Increase;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) to effect timely such notifications and filings as may be required pursuant to applicable law (such as a PDMR dealing reporting or a transparency filing, as applicable).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3. [Unless we provide the Company with full and complete dematerialization instructions by November 14, 2025, we agree that the New Shares shall be delivered in registered form.]

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4. [We agree that the New Shares shall be delivered in registered form.]

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5. We confirm that no regulatory consents or approvals are required by any governmental or other regulatory body for our taking any of the actions set forth herein.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6. We confirm that we do not possess any "inside information" with respect to the Company as such term is defined in Regulation 596/2014 of the European Parliament and the Council of the European Union dated 16 April 2014 on market abuse.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7. We confirm that our investment decision is based upon our own judgment and analysis, and that we are aware of the risks associated therewith and have the information we deem relevant for making our investment decision. We, either alone or together with our representatives, has such knowledge, sophistication and experience in business and financial matters so as to be capable of evaluating the merits and risks of the prospective investment in the New Shares, and has so evaluated the merits and risks of such investment. We are able to bear the economic risk of an investment in the New Shares and, at the present time, are able to afford a complete loss of such investment. Furthermore, our Subscription Commitment is made on the understanding that the Company is in compliance in all material respects with its public disclosure and reporting obligations pursuant to applicable law.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8. We acknowledge and agree that neither the Company nor any of its directors and officers have made any representations or warranties to us, express or implied, with respect to the Company, the Private Placement or the New Shares and, therefore, we will not hold the Company or any of its directors or officers in any way liable to us in relation to this Subscription Commitment Letter and the subscription of the New Shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;9. We confirm that we have sufficient funds available for the timely performance of our obligations under this Subscription Commitment Letter.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10. [We confirm that we are a non-U.S. Person (as such term is defined under in Rule 902 of Regulation S ()"**Regulation S**") under the Securities Act of 1933, as amended (the "**Securities Act** ")), and understand that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) we (i) are acquiring the New Shares outside the United States in an offshore transaction meeting the requirements of Regulation S; (ii) are not acquiring, have not offered, and will not offer prior to the expiration of the Distribution Compliance Period (as defined herein) the New Shares for the account or benefit of any U.S. Person; (iii) did not become aware of the Company or the New Shares through any form of "directed selling efforts" (as defined in Rule 902 of Regulation S); (iv) were outside the United States at the time of the origination of contact concerning the transactions contemplated by this Subscription Commitment Letter and on the date of execution and delivery of this Subscription Commitment Letter by the Undersigned; (v) are not acquiring the New Shares in a transaction or part of series of transactions that, although in technical compliance with Regulation S, is part of a plan or scheme to evade the registration provisions of the Securities Act; (vi) are neither a U.S. Person nor a Distributor (in each case, as defined in Rule 902 of Regulation S) and (vii) are the sole beneficial owner of the New Shares specified on signature pages hereto and have not pre-arranged any sale with a purchaser in the United States;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the New Shares are subject to a 40 day "distribution compliance period" (as defined in Regulation S) (the "**Distribution Compliance Period** "), and the Undersigned acknowledges and agrees that therefore the New Shares may only be offered or sold, prior to the expiration of the Distribution Compliance Period, (i) in accordance with Rule 903 or 904 of Regulation S, (ii) pursuant to registration of the New Shares under the Securities Act, or (iii) pursuant to an available exemption from the registration requirements of the Securities Act and upon delivery of an opinion of counsel reasonably satisfactory to the Company to such effect; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) that the New Shares are "restricted securities" within the meaning of the Securities Act and have not been and will not be registered under the Securities Act or with any securities regulatory authority of any state or other jurisdiction of the United States and that any offer and sale of the New Shares to it is being made in reliance on an exemption from, or in a transaction not subject to, the registration requirements of the Securities Act in a transaction not involving any public offering in the United States.]

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;11. [We confirm that we are a U.S. Person (as defined in Rule 902 of Regulation S), and:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) hereby represent and warrant that we (i) as of the date of this Agreement are, if an entity, a "qualified institutional buyer" (as defined in Rule 144A under the Securities Act) or an institutional "accredited investor" as that term is defined in Rule 501(a) under Regulation D promulgated pursuant to the Securities Act; or (ii) if an individual, are an "accredited investor" as that term is defined in Rule 501(a) of Regulation D of the Securities Act and have such knowledge and experience in financial and business matters as to be able to protect our own interests in connection with an investment in the New Shares. We further represent and warrant that (x) we are capable of evaluating the merits and risk of such investment, and (y) that we have not been organized for the purpose of acquiring the New Shares and we are an "institutional account" as defined by FINRA Rule 4512(c). We understand and agree that the offering and sale of the New Shares has not been registered under the Securities Act or any applicable state securities laws and is being made in reliance upon federal and state exemptions for transactions not involving a public offering which depend upon, among other things, the bona fide nature of the investment intent and the accuracy of the Undersigned's representations as expressed herein;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) acknowledge we are purchasing the New Shares solely for our own account and not for the account of others, and not with a view to the resale or distribution of any part thereof in violation of the Securities Act, and we have no present intention of selling, granting any participation in, or otherwise distributing the same in violation of the Securities Act without prejudice, however, to our right at all times to sell or otherwise dispose of all or any part of such New Shares in compliance with applicable United States federal and state securities laws. Notwithstanding the foregoing, if we are purchasing the New Shares as a fiduciary or agent for one or more investor accounts, we have full investment discretion with respect to each such account, and the full power and authority to make the acknowledgements, representations and agreements herein on behalf of each owner of each such account. We have no present arrangement to sell the New Shares to or through any person or entity. We understand that the New Shares must be held indefinitely unless such New Shares are resold pursuant to a registration statement under the Securities Act or an exemption from registration is available.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) acknowledge and agree that the New Shares are being offered in a transaction not involving any public offering within the meaning of the Securities Act, and we understand that the New Share have not been registered under the Securities Act, by reason of their issuance by the Company in a transaction exempt from the registration requirements of the Securities Act, and that the New Share must continue to be held

------

and may not be offered, resold, transferred, pledged or otherwise disposed of by the Undersigned unless a subsequent disposition thereof is registered under the Securities Act or is exempt from such registration and in each case in accordance with any applicable securities laws of any state of the United States. We understand that the exemptions from registration afforded by Rule 144 promulgated under the Securities Act depend on the satisfaction of various conditions including, but not limited to, the time and manner of sale, the holding period and on requirements relating to the Company which are outside of the Undersigned's control and which the Company may not be able to satisfy, and that, if applicable, Rule 144 may afford the basis for sales only in limited amounts. We acknowledge and agrees that we have been advised to consult legal counsel prior to making any offer, resale, transfer, pledge or disposition of any of the New Shares. We acknowledge that no federal or state agency has passed upon or endorsed the merits of the offering of the New Shares or made any findings or determination as to the fairness of this investment

We understand that any certificates or book entry notations evidencing the New Shares may bear one or more legends in substantially the following form and substance:

"THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE "SECURITIES ACT"), OR THE SECURITIES LAWS OF ANY STATE OF THE UNITED STATES. THE SECURITIES HAVE BEEN ACQUIRED FOR INVESTMENT AND MAY NOT BE SOLD, TRANSFERRED OR ASSIGNED UNLESS (I) SUCH SECURITIES HAVE BEEN REGISTERED FOR SALE PURSUANT TO THE SECURITIES ACT, (II) SUCH SECURITIES MAY BE SOLD PURSUANT TO RULE 144, (III) THE COMPANY HAS RECEIVED AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO IT THAT SUCH TRANSFER MAY LAWFULLY BE MADE WITHOUT REGISTRATION UNDER THE SECURITIES ACT, OR (IV) THE SECURITIES ARE TRANSFERRED WITHOUT CONSIDERATION TO AN AFFILIATE OF SUCH HOLDER OR A CUSTODIAL NOMINEE (WHICH FOR THE AVOIDANCE OF DOUBT SHALL REQUIRE NEITHER CONSENT NOR THE DELIVERY OF AN OPINION);" and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) acknowledge that we are not purchasing the New Shares as a result of any advertisement, article, notice or other communication regarding the New Shares published in any newspaper, magazine or similar media or broadcast over television or radio or presented at any seminar or, to the Undersigned's knowledge, any other general solicitation or general advertisement.]

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;12. This Subscription Commitment Letter and its contents are confidential, and cannot be disclosed to any third party, except:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) to the extent that disclosure is required by law, rule or regulation, or any competent securities exchange or other governmental authority;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) as necessary to support a claim or defense in litigation between the parties;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) as otherwise agreed in writing between the parties.

Notwithstanding the foregoing, we consent to that, *inter alia*, the press release and other disclosure or information materials to be prepared by the Company in respect of the Private Placement will refer to our commitments herein, and that this Subscription Commitment Letter will be available for inspection for such periods as may be required by any regulatory authority.

------

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13. This Subscription Commitment Letter contains the entire agreement between the parties with respect to its subject matter. It replaces and annuls all prior agreements, communications, offers, proposals or correspondence, oral or written, exchanged or concluded relating to the same subject matter.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;14. No addition to, variation, novation or agreed cancellation of this Subscription Commitment Letter shall be of any force or effect unless in writing and signed by or on behalf of us and the Company.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;15. This Subscription Commitment Letter and any dispute or claim arising out of or in connection with this letter or its subject matter or formation (including non-contractual disputes or claims) shall be governed by and construed in accordance with the laws of Belgium (without application of the conflict of law rules thereunder). The courts within the city of Brussels (Belgium) are to have exclusive jurisdiction to settle any dispute which may arise out of or in connection with this letter.

Yours faithfully,

On behalf of **[investor]**,

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| | |
|:---|:---|
| By: |  |
|  | Name: |
|  | Title: |
| By: |  |
|  | Name: |
|  | Title: |
| For acknowledgment and agreement on behalf of the Company, | For acknowledgment and agreement on behalf of the Company, |
| By: |  |
|  | Name: |
|  | Title: |
|  | Date: |

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## Exhibit 4.19

**exhibit 4.19**

**SECURITIES PURCHASE AGREEMENT**

This Securities Purchase Agreement (this "<u>Agreement</u>"), dated as of November 13, 2025, is between Nyxoah SA, a limited liability company (*naamloze vennootschap/société anonyme*) organized under the laws of Belgium whose registered office is at Rue Edouard Belin 12, 1435 Mont-Saint-Guibert, Belgium, registered with the Crossroads Bank for Enterprises under number 0817.149.675 (Register of Legal Entities Brabant Wallon) (the "<u>Company</u>"), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a "<u>Purchaser</u>" and collectively the "<u>Purchasers</u>").

WHEREAS, subject to the terms and conditions set forth in this Agreement and pursuant to an effective registration statement under the Securities Act of 1933, as amended (the "<u>Securities Act</u>"), the Company desires to issue and sell to each Purchaser, and each Purchaser, severally and not jointly, desires to subscribe and purchase from the Company, securities of the Company as more fully described in this Agreement.

NOW, THEREFORE, IN CONSIDERATION of the mutual covenants contained in this Agreement, and for other good and valuable consideration the receipt and adequacy of which are hereby acknowledged, the Company and each Purchaser agree as follows:

**ARTICLE I.**

DEFINITIONS

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.1<u>Definitions</u>. In addition to the terms defined elsewhere in this Agreement, for all purposes of this Agreement, the following terms have the meanings set forth in this Section 1.1:

"<u>Acquiring Person</u>" shall have the meaning ascribed to such term in Section 4.4.

"<u>Action</u>" shall have the meaning ascribed to such term in Section 3.1(j).

"<u>Affiliate</u>" means any Person that, directly or indirectly through one or more intermediaries, controls or is controlled by or is under common control with a Person as such terms are used in and construed under Rule 405 under the Securities Act.

"<u>Board of Directors</u>" means the board of directors of the Company.

"<u>Business Day</u>" means any day except any Saturday, any Sunday, any day which is a federal legal holiday in the United States or Kingdom of Brussels or any day on which banking institutions in the City of New York or Brussels, Belgium are authorized or required by law or other governmental action to close.

"<u>Closing</u>" means the closing of the subscription, purchase and sale of the Shares pursuant to Section 2.1.

"<u>Closing Date</u>" means the Trading Day on which all of the Transaction Documents have been executed and delivered by the applicable parties thereto, and all conditions precedent to (i) the Purchasers' obligations to pay the Subscription Amount and (ii) the

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Company's obligations to deliver the Shares, in each case, have been satisfied or waived, but in no event later than the second (2<sup>nd</sup>) Trading Day following the date hereof.

"<u>CMS</u>" shall have the meaning ascribed to such term in Section 3.1(hh)(i).

"<u>Commission</u>" means the United States Securities and Exchange Commission.

"<u>Company Belgian Counsel</u>" means NautaDutilh BV/SRL, with offices located at Chaussee de La Hulpe 120, 1000 Brussels, Belgium.

"<u>Company US Counsel</u>" means Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., with offices located at One Financial Center, Boston, Massachusetts 02111.

"<u>Disclosure Time</u>" means, (i) if this Agreement is signed on a day that is not a Trading Day or after 9:00 a.m. (New York City time) and before midnight (New York City time) on any Trading Day, 9:01 a.m. (New York City time) on the Trading Day immediately following the date hereof, and (ii) if this Agreement is signed between midnight (New York City time) and 9:00 a.m. (New York City time) on any Trading Day, no later than 9:01 a.m. (New York City time) on the date hereof.

"<u>Evaluation Date</u>" shall have the meaning ascribed to such term in Section 3.1(r).

"<u>Exchange Act</u>" means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder.

"<u>Exempt Issuance</u>" means the issuance of (a) of Ordinary Shares, subscription rights, warrants, options or other equity awards to employees, officers or directors of the Company pursuant to any stock or option plan duly adopted for such purpose, which issuance was approved by a majority of the non-employee members of the Board of Directors or a majority of the members of a committee of non-employee directors established for such purpose for services rendered to the Company, (b) securities exercisable or exchangeable for or convertible into Ordinary Shares issued and outstanding on the date of this Agreement, provided that such securities have not been amended since the date of this Agreement to increase the number of such securities or to decrease the exercise price, exchange price or conversion price of such securities (other than in connection with stock splits or combinations) or to extend the term of such securities, and (c) securities issued pursuant to acquisitions or strategic transactions or issued in connection with any joint venture, commercial or collaborative relationship, or the acquisition or license by the Company of the securities, business, property or other assets approved by a majority of the disinterested directors of the Company, provided that such securities are issued as "restricted securities" (as defined in Rule 144) and carry no registration rights that require or permit the filing of any registration statement in connection therewith during the prohibition period in Section 4.9(a) herein, and provided that any such issuance shall only be to a Person (or to the equityholders of a Person) which is, itself or through its subsidiaries, an operating company or an owner of an asset in a business synergistic with the business of the Company and shall provide to the Company additional benefits in addition to the investment of funds, but shall not include a transaction

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in which the Company is issuing securities primarily for the purpose of raising capital or to an entity whose primary business is investing in securities.

"<u>FCPA</u>" means the Foreign Corrupt Practices Act of 1977, as amended.

"<u>FDA</u>" shall have the meaning ascribed to such term in Section 3.1(hh)(i).

"<u>Health Care Laws</u>" shall have the meaning ascribed to such term in Section 3.1(gg)(ii).

"<u>HHS</u>" shall have the meaning ascribed to such term in Section 3.1(hh)(i).

"<u>HIPAA</u>" shall have the meaning ascribed to such term in Section 3.1(hh)(i).

"<u>IFRS</u>" shall have the meaning ascribed to such term in Section 3.1(h).

"<u>Indebtedness</u>" shall have the meaning ascribed to such term in Section 3.1(z).

"<u>Intellectual Property</u>" shall mean patents, patent applications, trade and service marks, trade and service mark registrations, trade names, copyrights, licenses, inventions, trade secrets, domain names, technology, know-how and other intellectual property in the United States and foreign jurisdictions.

"<u>Liens</u>" means a lien, charge, pledge, security interest, encumbrance, right of first refusal, preemptive right or other restriction.

"<u>Material Adverse Effect</u>" shall have the meaning assigned to such term in Section 3.1(b).

"<u>NCAs</u>" shall have the meaning ascribed to such term in Section 3.1(hh)(i).

"<u>Ordinary Shares</u>" means the ordinary shares of the Company, no nominal value per share, and any other class of securities into which such securities may hereafter be reclassified or changed.

"<u>Ordinary Share Equivalents</u>" means any securities of the Company or the Subsidiaries which would entitle the holder thereof to acquire at any time Ordinary Shares, including, without limitation, any debt, preferred stock, right, option, warrant or other instrument that is at any time convertible into or exercisable or exchangeable for, or otherwise entitles the holder thereof to receive, Ordinary Shares.

"<u>Permits</u>" shall have the meaning ascribed to such term in Section 3.1(hh)(i).

"<u>Per Share Purchase Price</u>" equals US$4.6304, subject to adjustment for reverse and forward stock splits, stock dividends, stock combinations and other similar transactions of the Ordinary Shares that occur after the date of this Agreement.

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"<u>Person</u>" means an individual or corporation, partnership, trust, incorporated or unincorporated association, joint venture, limited liability company, joint stock company, government (or an agency or subdivision thereof) or other entity of any kind.

"<u>Proceeding</u>" means an action, claim, suit, investigation or proceeding (including, without limitation, a partial proceeding, such as a deposition), whether commenced or threatened in writing.

"<u>Prospectus</u>" means (a) the final base prospectus included in the Registration Statement, including all information, documents and exhibits filed with or incorporated by reference into such prospectus, and (b) the free writing prospectus dated November 13, 2025.

"<u>Prospectus Supplement</u>" means the supplement to the Prospectus complying with Rule 424(b) of the Securities Act with respect to the offer and sale of the Shares, including all information, documents and exhibits filed with or incorporated by reference into such prospectus supplement, that will be filed with the Commission.

"<u>Purchaser Party</u>" shall have the meaning ascribed to such term in Section 4.7.

"<u>Registration Statement</u>" means the effective shelf registration statement on Form F-3 on file with Commission (File No. 333-268955) which registers the sale of the Ordinary Shares to the Purchasers.

"<u>Required Approvals</u>" shall have the meaning ascribed to such term in Section 3.1(e).

"<u>Rule 144</u>" means Rule 144 promulgated by the Commission pursuant to the Securities Act, as such Rule may be amended or interpreted from time to time, or any similar rule or regulation hereafter adopted by the Commission having substantially the same purpose and effect as such Rule.

"<u>Rule 424</u>" means Rule 424 promulgated by the Commission pursuant to the Securities Act, as such Rule may be amended or interpreted from time to time, or any similar rule or regulation hereafter adopted by the Commission having substantially the same purpose and effect as such Rule.

"<u>SEC Reports</u>" shall have the meaning ascribed to such term in Section 3.1(h).

"<u>Securities Act</u>" means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder.

"<u>Shares</u>" means the Ordinary Shares issued or issuable to each Purchaser pursuant to this Agreement.

"<u>Short Sales</u>" means all "short sales" as defined in Rule 200 of Regulation SHO under the Exchange Act (but shall not be deemed to include locating and/or borrowing Ordinary Shares).

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"<u>Subscription Amount</u>" means, as to each Purchaser, the aggregate amount to be paid for Shares purchased hereunder as specified below such Purchaser's name on the signature page of this Agreement and next to the heading "Subscription Amount," in United States dollars and in immediately available funds.

"<u>Subsidiary</u>" means any subsidiary of the Company as set forth in the SEC Reports, and shall, where applicable, also include any direct or indirect subsidiary of the Company formed or acquired after the date hereof.

"<u>Trading Day</u>" means a day on which the principal Trading Market is open for trading.

"<u>Trading Market</u>" means any of the following markets or exchanges on which the Ordinary Shares are listed or quoted for trading on the date in question: the NYSE American, the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq Global Select Market, the New York Stock Exchange, OTCQB, OTCQX or Euronext Brussels (or any successors to any of the foregoing).

"<u>Transaction Documents</u>" means this Agreement, all exhibits and schedules thereto and hereto and any other documents or agreements executed in connection with the transactions contemplated hereunder.

"<u>Transfer Agent</u>" means Computershare Trust Company, N.A., the current transfer agent of the Company, and any successor transfer agent of the Company.

**ARTICLE II.**

PURCHASE AND SALE

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.1<u>Closing</u><u>s</u>.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)<u>Closing</u>. On the Closing Date, upon the terms and subject to the conditions set forth herein, the Company agrees to issue and sell, and the Purchasers, severally and not jointly, agree to subscribe and purchase, the number of Shares set forth under the heading "Subscription Amount" on the Purchaser's signature page hereto at the Per Share Purchase Price. Each Purchaser's Subscription Amount shall be delivered by wire transfer to a bank account designated by the Company. The Company shall deliver or cause to be delivered to each Purchaser its respective Shares as determined pursuant to Section 2.2(a), and the Company and each Purchaser shall deliver the other items set forth in Section 2.2 deliverable at the Closing. Upon satisfaction of the covenants and conditions set forth in Sections 2.2 and 2.3, the Closing shall occur at the offices of the Company US Counsel or such other location as the parties shall mutually agree or shall take place remotely by electronic transfer of the Closing documentation. On the Closing Date, the Company shall issue the Shares in book entry form registered in the Purchasers' names released by the Transfer Agent directly in DTC or Euroclear Belgium to the account(s) identified by each Purchaser following receipt of payment therefor.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.2<u>Deliveries</u>.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)On or prior to the Closing Date, the Company shall deliver or cause to be delivered to each Purchaser the following:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)this Agreement duly executed by the Company;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)a legal opinion of each of Company US Counsel, in the form and substance reasonable acceptable to the Purchasers, and Company Belgian Counsel, in the form and substance reasonable acceptable to the Purchasers;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)the Company's wire instructions, on Company letterhead and executed by the Chief Executive Officer or Chief Financial Officer;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv)subject to Section 2.1, a copy of the irrevocable instructions to the Transfer Agent instructing the Transfer Agent to deliver on an expedited basis, via The Depository Trust Company Deposit or Withdrawal at Custodian system ("<u>DWAC</u>"), the Shares equal to such Purchaser's Subscription Amount divided by the Per Share Purchase Price (rounded down to the nearest whole share), registered in the name of such Purchaser; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v)the Prospectus and Prospectus Supplement (which may be delivered in accordance with Rule 172 under the Securities Act).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)On or prior to the Closing Date, each Purchaser shall deliver or cause to be delivered to the Company this Agreement duly executed by such Purchaser; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)On or prior to the Trading Day immediately following the date hereof, each Purchaser shall deliver or cause to be delivered and credited such Purchaser's Subscription Amount by wire transfer to the bank account specified in writing by the Company (with value date no later than 10 a.m. CET on the Closing Date and without deduction of any transfer costs, fees, expenses or other charges).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.3<u>Closing Conditions</u>.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)The obligations of the Company hereunder in connection with the Closing are subject to the following conditions being met:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)the accuracy in all material respects (or, to the extent representations or warranties are qualified by materiality or Material Adverse Effect, in all respects) when made and on the Closing Date of the representations and warranties of the Purchasers contained herein (unless as of a specific date therein in which case they shall be accurate as of such date);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)all obligations, covenants and agreements of each Purchaser required to be performed at or prior to the Closing Date shall have been performed; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)the delivery by each Purchaser of the items set forth in Section 2.2(b) of this Agreement.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)The respective obligations of the Purchasers hereunder in connection with the Closing are subject to the following conditions being met:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)the accuracy in all material respects (or, to the extent representations or warranties are qualified by materiality or Material Adverse Effect, in all respects) when made and on the Closing Date of the representations and warranties of the Company contained herein (unless as of a specific date therein in which case they shall be accurate as of such date);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)all obligations, covenants and agreements of the Company required to be performed at or prior to the Closing Date shall have been performed;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)the delivery by the Company of the items set forth in Section 2.2(a) of this Agreement;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv)there shall have been no Material Adverse Effect with respect to the Company since the date hereof; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v)from the date hereof to the Closing Date, trading in the Ordinary Shares shall not have been suspended by the Commission or the Company's principal Trading Market, and, at any time prior to the Closing Date, trading in securities generally on any nationally recognized securities exchange as reported by Bloomberg L.P. shall not have been suspended or limited, or minimum prices shall not have been established on securities whose trades are reported by such service, or on any Trading Market, nor shall a banking moratorium have been declared either by the United States or New York State authorities nor shall there have occurred any material outbreak or escalation of hostilities or other national or international calamity of such magnitude in its effect on, or any material adverse change in, any financial market which, in each case, in the reasonable judgment of such Purchaser, makes it impracticable or inadvisable to purchase the Shares at the Closing.

**ARTICLE III.**

REPRESENTATIONS AND WARRANTIES

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.1<u>Representations and Warranties of the Company</u>. The Company hereby makes the following representations and warranties to each Purchaser:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)<u>Subsidiaries</u>. All of the direct and indirect subsidiaries of the Company that are wholly owned (directly or indirectly) by the Company or that constitute significant subsidiaries within the meaning of Item 601(b)(21)(ii) of Regulation S-K are set forth in the SEC Reports. Except as set forth in the SEC Reports, the Company owns, directly or indirectly, all of the capital stock or other equity interests of each Subsidiary free and clear of any Liens, and all of the issued and outstanding shares of capital stock of each Subsidiary are validly issued and are fully paid, non-assessable and free of preemptive and similar rights to subscribe for or purchase securities.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)<u>Organization and Qualification</u>. The Company and each of the Subsidiaries is an entity duly incorporated or otherwise organized, validly existing and, if applicable under the laws of the applicable jurisdiction, in good standing under the laws of the jurisdiction of its incorporation or organization, with the requisite power and authority to own and use its properties and assets and to carry on its business as currently conducted. Neither the Company nor any Subsidiary is in violation nor default of any of the provisions of its respective certificate or articles of association, bylaws or other organizational or charter documents. Each of the Company and the Subsidiaries is duly qualified to conduct business and is in good standing as a foreign corporation or other entity in each jurisdiction in which the nature of the business conducted or property owned by it makes such qualification necessary, except where the failure to be so qualified or in good standing, as the case may be, would not have or reasonably be expected to result in: (i) a material adverse effect on the legality, validity or enforceability of any Transaction Document, (ii) a material adverse effect on the results of operations, assets, business, or condition (financial or otherwise) of the Company and the Subsidiaries, taken as a whole, or (iii) a material adverse effect on the Company's ability to perform in any material respect on a timely basis its obligations under any Transaction Document (any of (i), (ii) or (iii), a "<u>Material Adverse Effect</u>;" <u>provided</u>, <u>however</u>, that changes in the trading price or trading volume of the Ordinary Shares shall not, in and of itself, constitute a Material Adverse Effect) and no Proceeding has been instituted in any such jurisdiction revoking, limiting or curtailing or seeking to revoke, limit or curtail such power and authority or qualification.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)<u>Authorization; Enforcement</u>. This Agreement has been duly authorized, executed and delivered by the Company, and constitutes a valid, legal and binding obligation of the Company, enforceable in accordance with its terms, except (i) as limited by general equitable principles and applicable bankruptcy, insolvency, reorganization, moratorium and other laws of general application affecting enforcement of creditors' rights generally, (ii) as limited by laws relating to the availability of specific performance, injunctive relief or other equitable remedies and (iii) insofar as indemnification and contribution provisions may be limited by applicable law. All action on the part of the Company, its officers, directors and shareholders necessary for the authorization of the Shares, the authorization, execution, delivery and performance of the Transaction Agreements and the consummation of the transactions contemplated herein, including the issuance and sale of the Shares, has been taken, and no further action is required by the Company, the Board of Directors or the Company's shareholders in connection herewith or therewith other than in connection with the Required Approvals.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)<u>No Conflicts</u>. The execution, delivery and performance by the Company of this Agreement and the other Transaction Documents to which it is a party, the issuance and sale of the Shares and the consummation by it of the transactions contemplated hereby and thereby do not and will not (i) conflict with or violate any provision of the Company's or any Subsidiary's certificate or articles of association, bylaws or other organizational or charter documents, or (ii) conflict with, or constitute a default (or an event that with notice or lapse of time or both would become a default) under, result in the creation of any Lien upon any of the properties or assets of the Company or any Subsidiary, or give to others any rights of termination, amendment, anti-dilution or similar adjustments, acceleration or cancellation (with or without notice, lapse of time or both) of, any agreement, credit

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facility, debt or other instrument (evidencing a Company or Subsidiary debt or otherwise) or other understanding to which the Company or any Subsidiary is a party or by which any property or asset of the Company or any Subsidiary is bound or affected, or (iii) subject to the Required Approvals, conflict with or result in a violation of any law, rule, regulation, order, judgment, injunction, decree or other restriction of any court or governmental authority to which the Company or a Subsidiary is subject (including federal and state securities laws and regulations), or by which any property or asset of the Company or a Subsidiary is bound or affected; except in the case of each of clauses (ii) and (iii), such as would not have or reasonably be expected to result in a Material Adverse Effect.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e)<u>Filings, Consents and Approvals</u>. The Company is not required to obtain any consent, waiver, authorization or order of, give any notice to, or make any filing or registration with, any court or other federal, state, local or other governmental authority or other Person in connection with the execution, delivery and performance by the Company of the Transaction Documents, other than: (i) the filings required pursuant to Section 4.3 of this Agreement, (ii) the filing with the Commission of the Prospectus Supplement, (iii) notice and/or application(s) to each applicable Trading Market for the listing of the Shares for trading thereon in the time and manner required thereby, and (iv) such filings as are required to be made under applicable state securities laws, the rule of the Financial Industry Regulatory Authority, Inc. and/or applicable Belgian company law (collectively, the "<u>Required Approvals</u>").

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f)<u>Issuance of the Securities; Registration</u>. The Shares are duly authorized and, when issued and paid for in accordance with the applicable Transaction Documents, will be duly and validly issued, fully paid and nonassessable, free and clear of all Liens imposed by the Company. The Company has prepared and filed the Registration Statement in conformity with the requirements of the Securities Act, including the Prospectus, and such amendments and supplements thereto as may have been required to the date of this Agreement. The Registration Statement is effective under the Securities Act and no stop order preventing or suspending the effectiveness of the Registration Statement or suspending or preventing the use of the Prospectus has been issued by the Commission and no proceedings for that purpose have been instituted or, to the knowledge of the Company, are threatened in writing by the Commission. The Company shall timely file the Prospectus Supplement with the Commission pursuant to Rule 424(b). At the time the Registration Statement and any post-effective amendments thereto became effective, at the date of this Agreement and at the Closing Date, the Registration Statement and any amendments thereto conformed and will conform in all material respects to the requirements of the Securities Act and did not and will not contain any untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary to make the statements therein not misleading; and the Prospectus Supplement and any amendments or supplements thereto, at the time the Prospectus Supplement or any amendment or supplement thereto was issued and at the Closing Date, conformed and will conform in all material respects to the requirements of the Securities Act and did not and will not contain an untrue statement of a material fact or omit to state a material fact necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading. The Company is eligible to use Form F-3 under the Securities Act and, at

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the time of filing of the Registration Statement, it met the transaction requirements as set forth in General Instruction I.B.1 of Form F-3.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g)<u>Capitalization</u>. The capitalization of the Company is as set forth in the SEC Reports as of the dates specified therein. Except as disclosed in the Prospectus Supplement, the Company has not issued any capital stock since its most recently filed Report on Form 6-K under the Exchange Act, other than the exercise of or the vesting of equity awards under the Company's equity plans or arrangements, the issuance of Ordinary Shares to employees pursuant to the Company's equity plans or employee stock purchase plans, pursuant to the conversion and/or exercise of Ordinary Share Equivalents outstanding as of the date of the most recently filed Report on Form 6-K under the Exchange Act. Except as disclosed in the SEC Reports or as has been waived, no Person has any right of first refusal, preemptive right, right of participation, or any similar right to participate in the transactions contemplated by the Transaction Documents. Except as a result of the purchase and sale of the Shares and as disclosed in the SEC Reports, there are no outstanding options, warrants, scrip rights to subscribe to, calls or commitments of any character whatsoever relating to, or securities, rights or obligations convertible into or exercisable or exchangeable for, or giving any Person any right to subscribe for or acquire, any Ordinary Shares or the capital stock of any Subsidiary, or contracts, commitments, understandings or arrangements by which the Company or any Subsidiary is or may become bound to issue Ordinary Shares or Ordinary Share Equivalents or capital stock of any Subsidiary. The issuance and sale of the Shares will not obligate the Company or any Subsidiary to issue Ordinary Shares or other securities to any Person (other than the Purchasers). There are no outstanding securities or instruments of the Company or any Subsidiary with any provision that adjusts the exercise, conversion, exchange or reset price of such security or instrument upon an issuance of securities by the Company or any Subsidiary. There are no outstanding securities or instruments of the Company or any Subsidiary that contain any redemption or similar provisions, and there are no contracts, commitments, understandings or arrangements by which the Company or any Subsidiary is or may become bound to redeem a security of the Company or such Subsidiary. The Company does not have any stock appreciation rights or "phantom stock" plans or agreements or any similar plan or agreement. All of the outstanding shares of capital stock of the Company were duly authorized, validly issued, fully paid and nonassessable, have been issued in compliance with all federal and state securities laws, and none of such outstanding shares was issued in violation of any preemptive rights or similar rights to subscribe for or purchase securities. Apart from the decision of the Board of Directors, within the framework of the authorized capital, to issue the Shares on Closing, no further approval or authorization of any shareholder, the Board of Directors or others is required for the issuance and sale of the Shares. Other than this Agreement, there are no stockholders agreements, voting agreements or other similar agreements with respect to the Company's capital stock to which the Company is a party or, to the knowledge of the Company, between or among any of the Company's shareholders.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h)<u>SEC Reports; Financial Statements</u>. The Company has filed all reports, schedules, forms, statements and other documents required to be filed by the Company under the Securities Act and the Exchange Act, including pursuant to Section 13(a) or 15(d) thereof, for the two years preceding the date hereof (or such shorter period as the Company

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was required by law or regulation to file such material) (the foregoing materials, including the exhibits thereto and documents incorporated by reference therein, together with the Prospectus and the Prospectus Supplement, being collectively referred to herein as the "<u>SEC Reports</u>") on a timely basis or has received a valid extension of such time of filing and has filed any such SEC Reports prior to the expiration of any such extension. As of their respective dates, the SEC Reports complied in all material respects with the requirements of the Securities Act and the Exchange Act, as applicable, and none of the SEC Reports, when filed, contained any untrue statement of a material fact or omitted to state a material fact required to be stated therein or necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading. The Company has never been an issuer subject to Rule 144(i) under the Securities Act. The financial statements of the Company included in the SEC Reports complied in all material respects with applicable accounting requirements and the rules and regulations of the Commission with respect thereto as in effect at the time of filing. Such financial statements have been prepared in accordance with International Financial Reporting Standards applied on a consistent basis during the periods involved ("<u>IFRS</u>"), except as may be otherwise specified in such financial statements or the notes thereto and except that unaudited financial statements may not contain all footnotes required by IFRS, and fairly present in all material respects the financial position of the Company and its consolidated Subsidiaries as of and for the dates thereof and the results of operations and cash flows for the periods then ended, subject, in the case of unaudited statements, to normal, immaterial, year-end audit adjustments.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)<u>Material Changes; Undisclosed Events, Liabilities or Developments</u>. Since the date of the most recent unaudited financial statements included within the SEC Reports, except as disclosed in the SEC Reports, (i) there has been no event, occurrence or development that has had or that would reasonably be expected to result in a Material Adverse Effect, (ii) the Company has not incurred any liabilities (contingent or otherwise) other than (A) trade payables and accrued expenses incurred in the ordinary course of business consistent with past practice and (B) liabilities not required to be reflected in the Company's financial statements pursuant to IFRS or disclosed in filings made with the Commission, (iii) the Company has not altered its method of accounting, (iv) the Company has not declared or made any dividend or distribution of cash or other property to its stockholders or purchased, redeemed or made any agreements to purchase or redeem any shares of its capital stock and (v) the Company has not issued any equity securities to any officer, director or Affiliate, except pursuant to existing Company stock option plans. The Company does not have pending before the Commission any request for confidential treatment of information.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(j)<u>Litigation</u>. Other than as set forth in the SEC Reports, there is no action, suit, inquiry, notice of violation, proceeding or investigation pending or, to the knowledge of the Company, threatened in writing against or affecting the Company, any Subsidiary or any of their respective properties before or by any court, arbitrator, governmental or administrative agency or regulatory authority (federal, state, county, local or foreign) (collectively, an "<u>Action</u>") which (i) adversely affects or challenges the legality, validity or enforceability of any of the Transaction Documents or the Securities or (ii) would, if there were an unfavorable decision, have or reasonably be expected to result in a Material

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Adverse Effect. Neither the Company nor any Subsidiary, nor any director or officer thereof, is or has been the subject of any Action involving a claim of violation of or liability under federal or state securities laws or a claim of breach of fiduciary duty. There has not been, and to the knowledge of the Company, there is not pending or contemplated, any investigation by the Commission involving the Company or, to the knowledge of the Company, any current or former director or officer of the Company (in his capacity as such). The Commission has not issued any stop order or other order suspending the effectiveness of any registration statement filed by the Company or any Subsidiary under the Exchange Act or the Securities Act.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(k)<u>Labor Relations</u>. No labor dispute exists or, to the knowledge of the Company, is imminent with respect to any of the employees of the Company, which would reasonably be expected to result in a Material Adverse Effect. None of the Company's or its Subsidiaries' employees is a member of a union that relates to such employee's relationship with the Company or such Subsidiary, and neither the Company nor any of its Subsidiaries is a party to a collective bargaining agreement. To the knowledge of the Company, no executive officer of the Company or any Subsidiary is in violation of any material term of any employment contract, confidentiality, disclosure or proprietary information agreement or non-competition agreement, or any restrictive covenant in favor of any third party, and the continued employment of each such executive officer does not subject the Company or any of its Subsidiaries to any liability with respect to any of the foregoing matters. The Company and its Subsidiaries are in compliance with all applicable U.S. federal, state, local and foreign laws and regulations relating to employment and employment practices, terms and conditions of employment and wages and hours, except where the failure to be in compliance would not, individually or in the aggregate, reasonably be expected to have a Material Adverse Effect.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(l)<u>Compliance</u>. Neither the Company nor any Subsidiary: (i) is in default under or in violation of (and no event has occurred that has not been waived that, with notice or lapse of time or both, would result in a default by the Company or any Subsidiary under), nor has the Company or any Subsidiary received written notice of a claim that it is in default under or that it is in violation of, any indenture, loan or credit agreement or any other agreement or instrument to which it is a party or by which it or any of its properties is bound (whether or not such default or violation has been waived), (ii) is in violation of any judgment, decree or order of any court, arbitrator or other governmental authority or (iii) is or has been in violation of any statute, rule, ordinance or regulation of any governmental authority, including without limitation all foreign, federal, state and local laws relating to taxes, environmental protection, occupational health and safety, product quality and safety and employment and labor matters, except in each case as would not have or reasonably be expected to result in a Material Adverse Effect.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(m)<u>Environmental Laws</u>. The Company and its Subsidiaries (i) are in compliance with all applicable federal, state, local and foreign laws relating to pollution or protection of human health or the environment (including ambient air, surface water, groundwater, land surface or subsurface strata), including laws relating to emissions, discharges, releases or threatened releases of chemicals, pollutants, contaminants, or toxic or hazardous substances or wastes (collectively, "<u>Hazardous Materials</u>") into the

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environment, or otherwise relating to the manufacture, processing, distribution, use, treatment, storage, disposal, transport or handling of Hazardous Materials, as well as all authorizations, codes, decrees, demands, or demand letters, injunctions, judgments, licenses, notices or notice letters, orders, permits, plans or regulations, issued, entered, promulgated or approved thereunder ("<u>Environmental Laws</u>"); (ii) have received all permits licenses or other approvals required of them under applicable Environmental Laws to conduct their respective businesses; and (iii) are in compliance with all terms and conditions of any such permit, license or approval where in each clause (i), (ii) and (iii), the failure to so comply would be reasonably expected to have, individually or in the aggregate, a Material Adverse Effect.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(n)<u>Regulatory Permits</u>. The Company and the Subsidiaries possess all certificates, authorizations and permits issued by the appropriate federal, state, local or foreign regulatory authorities necessary to conduct their respective businesses as described in the SEC Reports, except where the failure to possess such permits would not reasonably be expected to result in a Material Adverse Effect ("<u>Material Permits</u>"), and neither the Company nor any Subsidiary has received any written notice of proceedings relating to the revocation or modification of any Material Permit.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(o)<u>Title to Assets</u>. The Company and the Subsidiaries have good and marketable title in fee simple to all real property owned by them and good and marketable title in all personal property owned by them that is material to the business of the Company and the Subsidiaries, in each case free and clear of all Liens, except for (i) Liens as do not materially affect the value of such property and do not materially interfere with the use made and proposed to be made of such property by the Company and the Subsidiaries, (ii) Liens for the payment of federal, state, foreign or other taxes, for which appropriate reserves have been made therefor in accordance with IFRS and, the payment of which is neither delinquent nor subject to penalties, and (iii) Liens that would not, individually or in the aggregate, have or reasonably be expected to have a Material Adverse Effect. Any real property and facilities held under lease by the Company and the Subsidiaries are held by them under valid, subsisting and enforceable leases with which the Company and the Subsidiaries are in compliance in all material respects.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(p)<u>Intellectual Property</u>. The Company and each of its subsidiaries owns, possesses, or has the right to use all Intellectual Property necessary for the conduct of the Company's and it subsidiaries' business as now conducted or as proposed to be conducted, as described in the SEC Reports and the documents incorporated by reference therein to be conducted. The Company and its subsidiaries have complied in all material respects with the terms of each agreement pursuant to which Intellectual Property has been licensed to the Company or any subsidiary, and all such agreements are in full force and effect. Furthermore, (A) to the knowledge of the Company, there is no infringement, misappropriation or violation by third parties of any Intellectual Property owned by or licensed to the Company or its subsidiaries; (B) there is no pending or, to the knowledge of the Company, threatened, action, suit, proceeding or claim by others challenging the Company's or any of its subsidiaries' rights in or to any such Intellectual Property, neither the Company nor any of its subsidiaries has received any notice of any such claim, and the Company is unaware of any facts which would form a reasonable basis for any such claim;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(C) there are no third parties who have rights to any Intellectual Property owned by or licensed to the Company or its subsidiaries, including no liens, security interest, or other encumbrances, except for (i) customary reversionary rights of third-party licensors with respect to Intellectual Property that is disclosed in the SEC Reports and the documents incorporated by reference therein as licensed to the Company or one or more of its subsidiaries or (ii) rights or Intellectual Property that are not material to the Company's and it subsidiaries' business as now conducted or as proposed to be conducted; (D) the Intellectual Property owned by the Company and its subsidiaries, and to the knowledge of the Company, the Intellectual Property licensed to the Company and its subsidiaries, has not been adjudged invalid or unenforceable, in whole or in part, and there is no pending or, to the knowledge of the Company, threatened action, suit, proceeding or claim by others challenging the validity or scope of any such Intellectual Property; (E) there is no pending or, to the knowledge of the Company, threatened action, suit, proceeding or claim by others that the Company or any of its subsidiaries infringes, misappropriates or otherwise violates any Intellectual Property or other proprietary rights of others, and neither the Company nor any of its subsidiaries has received any written notice of such claim; (F) the conduct of the Company's and its subsidiaries' business as now conducted or as proposed to be conducted does not and will not infringe or otherwise violate any Intellectual Property or other proprietary right of any third party; (G) to the Company's knowledge, no employee of the Company or any of its subsidiaries is in or has ever been in violation of any term of any employment contract, patent disclosure agreement, invention assignment agreement, non-competition agreement, non-solicitation agreement, nondisclosure agreement or any restrictive covenant to or with a former employer where the basis of such violation relates to such employee's employment with the Company or any of its subsidiaries or actions undertaken by the employee while employed with the Company or any of its subsidiaries; (H) there is no prior art or public or commercial activity of which the Company is aware that may render any patent included in the Intellectual Property owned by or licensed to the Company or any of its subsidiaries invalid or that would preclude the issuance of any patent from any patent application included in such Intellectual Property, which has not been disclosed to the U.S. Patent and Trademark Office or the relevant foreign patent authority if required, as the case may be; (I) to the Company's knowledge, the issued patents included in the Intellectual Property owned by or licensed to the Company or any of its subsidiaries are valid and enforceable and the Company is unaware of any facts that would preclude the issuance of a valid and enforceable patent on any pending patent application included in such Intellectual Property; (J) the Company has taken reasonable steps necessary to secure the interests of the Company in the Intellectual Property purported to be owned by the Company or any of its subsidiaries from all employees, consultants, agents or contractors that developed (in whole or in part) such Intellectual Property; (K) no government funding, facilities or resources of a university, college, other educational institution or research center was used in the development of any Intellectual Property that is owned or purported to be owned by the Company that would confer upon any governmental agency or body, university, college, other educational institution or research center any claim or right in or to any such Intellectual Property; (L) to the Company's knowledge, none of the technology employed by the Company has been obtained or is being used by the Company in violation of the rights of any entity; and (M) all patents and patent applications owned by or licensed to the Company or any of its subsidiaries have

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been duly and properly filed, prosecuted and maintained in all material respects, have been assigned to the Company or the licensor to the Company, and the patents are subsisting and have not lapsed and the patent applications in the Intellectual Property are subsisting and have not been abandoned. The Company and its subsidiaries have taken commercially reasonable steps to safeguard the confidentiality of its confidential proprietary know-how and trade secrets, and to the Company's knowledge, no unauthorized disclosure of such know-how or trade secrets has occurred, except as would not, individually or in the aggregate, reasonably be expected to result in a Material Adverse Effect. "<u>Intellectual Property</u>" shall mean patents, patent applications, trade and service marks, trade and service mark registrations, trade names, copyrights, licenses, inventions, trade secrets, domain names, technology, know-how and other intellectual property in the United States and foreign jurisdictions.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(q)<u>Insurance</u>. The Company and the Subsidiaries are insured by insurers of recognized financial responsibility against such losses and risks and in such amounts as are prudent and customary in the businesses in which the Company and the Subsidiaries are engaged. Neither the Company nor any Subsidiary has any reason to believe that it will not be able to renew its existing insurance coverage as and when such coverage expires or to obtain similar coverage from similar insurers as may be necessary to continue its business without a significant increase in cost.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(r)<u>Related Party Transactions</u>. No relationship, direct or indirect, exists between or among the Company or any of its subsidiaries, on the one hand, and the directors, officers, shareholders, customers or suppliers of the Company, on the other hand, that is required to be described in the SEC Reports that is not so described.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(s)<u>Sarbanes-Oxley; Internal Accounting Controls</u>. The Company and the Subsidiaries are in compliance in all material respects with any and all applicable requirements of the Sarbanes-Oxley Act of 2002 that are effective as of the date hereof, and any and all applicable rules and regulations promulgated by the Commission thereunder that are effective as of the date hereof and as of the Closing Date and apply to the Company given its status as a foreign private issuer (as such term is defined under the Securities Act). The Company and the Subsidiaries maintain a system of internal accounting controls sufficient to provide reasonable assurance that: (i) transactions are executed in accordance with management's general or specific authorizations, (ii) transactions are recorded as necessary to permit preparation of financial statements in conformity with IFRS and to maintain asset accountability, (iii) access to assets is permitted only in accordance with management's general or specific authorization, and (iv) the recorded accountability for assets is compared with the existing assets at reasonable intervals and appropriate action is taken with respect to any differences. The Company and the Subsidiaries have established disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) for the Company and the Subsidiaries and designed such disclosure controls and procedures to ensure that information required to be disclosed by the Company in the reports it files or submits under the Exchange Act is recorded, processed, summarized and reported, within the time periods specified in the Commission's rules and forms. The Company's certifying officers have evaluated the effectiveness of the disclosure controls and procedures of the Company and the

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Subsidiaries as of the end of the period covered by the most recently filed Form 20-F under the Exchange Act (such date, the "<u>Evaluation Date</u>"). The Company presented in its most recently filed Form 20-F under the Exchange Act the conclusions of the certifying officers about the effectiveness of the disclosure controls and procedures based on their evaluations as of the Evaluation Date. Since the Evaluation Date, there have been no changes in the internal control over financial reporting (as such term is defined in the Exchange Act) of the Company and its Subsidiaries that have materially adversely affected, or is reasonably likely to materially adversely affect, the internal control over financial reporting of the Company and its Subsidiaries.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(t)<u>Certain Fees</u>. Except as set forth in the Prospectus Supplement, no brokerage or finder's fees or commissions are or will be payable by the Company or any Subsidiary to any broker, financial advisor or consultant, finder, placement agent, investment banker, bank or other Person with respect to the transactions contemplated by the Transaction Documents. The Purchasers shall have no obligation with respect to any fees or with respect to any claims made by or on behalf of other Persons for fees of a type contemplated in this Section that may be due in connection with the transactions contemplated by the Transaction Documents.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(u)<u>Investment Company</u>. The Company is not, and immediately after receipt of payment for the Shares will not be, an "investment company" within the meaning of the Investment Company Act of 1940, as amended.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v)<u>Registration Rights</u>. Except as set forth in the Prospectus Supplement, no Person has any right to cause the Company or any Subsidiary to effect the registration under the Securities Act of any securities of the Company or any Subsidiary.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(w)<u>Listing and Maintenance Requirements</u>. The Ordinary Shares are registered pursuant to Section 12(b) of the Exchange Act, and the Company has taken no action designed to, or which to its knowledge is reasonably likely to have the effect of, terminating the registration of the Ordinary Shares under the Exchange Act nor has the Company received any written notification that the Commission is contemplating terminating such registration. The Company has not, in the 12 months preceding the date hereof, received written notice from any Trading Market on which the Ordinary Shares are or have been listed or quoted to the effect that the Company is not in compliance with the listing or maintenance requirements of such Trading Market. The Ordinary Shares are currently eligible for electronic transfer through the Depository Trust Company or another established clearing corporation and the Company is current in payment of the fees to the Depository Trust Company (or such other established clearing corporation) in connection with such electronic transfer.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(x)<u>Application of Takeover Protections</u>. The Company and the Board of Directors have taken all necessary action, if any, in order to render inapplicable any control share acquisition, business combination, poison pill (including any distribution under a rights agreement) or other similar anti-takeover provision under the Company's articles of association (or similar charter documents) or the laws of its jurisdiction of incorporation that is or could become applicable to the Purchasers as a result of the Purchasers and the

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Company fulfilling their obligations or exercising their rights under the Transaction Documents, including without limitation as a result of the Company's issuance of the Shares and the Purchasers' ownership of the Shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(y)<u>Disclosure</u>. Except with respect to the material terms and conditions of the transactions contemplated by the Transaction Documents and the information set forth on <u>Schedule A</u> that has been orally conveyed to each of the Purchasers, the Company confirms that neither it nor any other Person acting on its behalf has provided any of the Purchasers or their agents or counsel with any information that it believes constitutes or might constitute material, non-public information which is not otherwise disclosed in the Prospectus or Prospectus Supplement. The Company understands and confirms that the Purchasers will rely on the foregoing representation in effecting transactions in securities of the Company. All of the disclosure furnished by or on behalf of the Company to the Purchasers regarding the Company and its Subsidiaries, their respective businesses and the transactions contemplated hereby is true and correct in all material respects and does not contain any untrue statement of a material fact or omit to state any material fact necessary in order to make the statements made therein, in the light of the circumstances under which they were made, not misleading (it being understood that such disclosure furnished by or on behalf of the Company to the Purchasers included the SEC Reports). The Company acknowledges and agrees that no Purchaser makes or has made any representations or warranties with respect to the transactions contemplated hereby other than those specifically set forth in Section 3.2 hereof.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(z)<u>No Integrated Offering</u>. Assuming the accuracy of the Purchasers' representations and warranties set forth in Section 3.2, neither the Company, nor any of its Affiliates, nor any Person acting on its or their behalf has, directly or indirectly, made any offers or sales of any security or solicited any offers to buy any security, under circumstances that would cause this offering of the Shares to be integrated with prior offerings by the Company for purposes of any applicable shareholder approval provisions of any Trading Market on which any of the securities of the Company are listed or designated.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(aa)<u>Solvency</u>. Based on the consolidated financial condition of the Company as of the Closing Date, after giving effect to the receipt by the Company of the proceeds from the sale of the Securities hereunder, (i) the fair saleable value of the Company's assets exceeds the amount that will be required to be paid on or in respect of the Company's existing debts and other liabilities (including known contingent liabilities) as they mature, (ii) the Company's assets do not constitute unreasonably small capital to carry on its business as now conducted and as proposed to be conducted including its capital needs taking into account the particular capital requirements of the business conducted by the Company, consolidated and projected capital requirements and capital availability thereof, and (iii) the current cash flow of the Company, together with the proceeds the Company would receive, were it to liquidate all of its assets, after taking into account all anticipated uses of the cash, would be sufficient to pay all amounts on or in respect of its liabilities when such amounts are required to be paid. The Company does not intend to incur debts beyond its ability to pay such debts as they mature (taking into account the timing and amounts of cash to be payable on or in respect of its debt). The Company has no knowledge

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of any facts or circumstances which lead it to believe that it will file for reorganization or liquidation under the bankruptcy or reorganization laws of any jurisdiction within six (6) months from the Closing Date. The SEC Reports set forth as of the date hereof all outstanding secured and unsecured Indebtedness of the Company or any Subsidiary, or for which the Company or any Subsidiary has commitments. For the purposes of this Agreement, "<u>Indebtedness</u>" means (x) any liabilities for borrowed money or amounts owed in excess of US$50,000 (other than trade accounts payable incurred in the ordinary course of business), (y) all guaranties, endorsements and other contingent obligations in respect of indebtedness of others, whether or not the same are or should be reflected in the Company's consolidated balance sheet (or the notes thereto), except guaranties by endorsement of negotiable instruments for deposit or collection or similar transactions in the ordinary course of business; and (z) the present value of any lease payments in excess of US$50,000 due under leases required to be capitalized in accordance with IFRS. Neither the Company nor any Subsidiary is in default with respect to any Indebtedness.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(bb)<u>Tax Status</u>. Except for matters that would not, individually or in the aggregate, have or reasonably be expected to result in a Material Adverse Effect, the Company and its Subsidiaries each (i) has made or filed all United States federal, state and local income and all foreign income and franchise tax returns, reports and declarations required by any jurisdiction to which it is subject, (ii) has paid all taxes and other governmental assessments and charges that are material in amount, shown or determined to be due on such returns, reports and declarations, except for such taxes, if any, as are being contested in good faith and as to which adequate reserves have been established by the Company, and (iii) has set aside on its books provision reasonably adequate for the payment of all material taxes for periods subsequent to the periods to which such returns, reports or declarations apply. There are no unpaid taxes in any material amount claimed to be due by the taxing authority of any jurisdiction, and the officers of the Company or of any Subsidiary know of no basis for any such claim.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(cc)<u>Foreign Corrupt Practices</u>. Neither the Company nor any Subsidiary, nor to the knowledge of the Company or any Subsidiary, any agent or other person acting on behalf of the Company or any Subsidiary, has (i) directly or indirectly, used any funds for unlawful contributions, gifts, entertainment or other unlawful expenses related to foreign or domestic political activity, (ii) made any unlawful payment to foreign or domestic government officials or employees or to any foreign or domestic political parties or campaigns from corporate funds, (iii) failed to disclose fully any contribution made by the Company or any Subsidiary (or made by any person acting on its behalf of which the Company is aware) which is in violation of law, or (iv) violated in any material respect any provision of FCPA.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(dd)<u>Accountants</u>. The Company's independent register public accounting firm is EY Réviseurs d'Entreprises/EY Bedrijfsrevisoren SRL/BV. To the knowledge and belief of the Company, such accounting firm (i) is a registered public accounting firm as required by the Exchange Act and (ii) has expressed its opinion with respect to the financial statements included in the Company's Annual Report for the fiscal year ending December 31, 2024.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ee)<u>Acknowledgment Regarding Purchasers' Purchase of Shares</u>. The Company acknowledges and agrees that each of the Purchasers is acting solely in the capacity of an arm's length purchaser with respect to the Transaction Documents and the transactions contemplated thereby. The Company further acknowledges that no Purchaser is acting as a financial advisor or fiduciary of the Company (or in any similar capacity) with respect to the Transaction Documents and the transactions contemplated thereby and any advice given by any Purchaser or any of their respective representatives or agents in connection with the Transaction Documents and the transactions contemplated thereby is merely incidental to the Purchasers' purchase of the Shares. The Company further represents to each Purchaser that the Company's decision to enter into this Agreement and the other Transaction Documents has been based solely on the independent evaluation of the transactions contemplated hereby by the Company and its representatives.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ff)<u>Acknowledgment Regarding Purchaser's Trading Activity</u>. Anything in this Agreement or elsewhere herein to the contrary notwithstanding (except for Sections 3.2(f) and 4.10 hereof), it is understood and acknowledged by the Company that: (i) none of the Purchasers has been asked by the Company to agree, nor has any Purchaser agreed, to desist from purchasing or selling, long and/or short, securities of the Company, or "derivative" securities based on securities issued by the Company or to hold the Shares for any specified term (except in accordance with the securities laws); (ii) past or future open market or other transactions by any Purchaser, specifically including, without limitation, Short Sales or "derivative" transactions, before or after the closing of this or future private placement transactions, may negatively impact the market price of the Company's publicly-traded securities; (iii) any Purchaser, and counter-parties in "derivative" transactions to which any such Purchaser is a party, directly or indirectly, presently may have a "short" position in the Ordinary Shares, and (iv) each Purchaser shall not be deemed to have any affiliation with or control over any arm's length counter-party in any "derivative" transaction. The Company further understands and acknowledges that (y) one or more Purchasers may engage in hedging activities at various times during the period that the Shares are outstanding, and (z) such hedging activities (if any) could reduce the value of the existing stockholders' equity interests in the Company at and after the time that the hedging activities are being conducted. The Company acknowledges that such aforementioned hedging activities do not constitute a breach of any of the Transaction Documents.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(gg)<u>Regulation M Compliance</u>. The Company has not, and to its knowledge no one acting on its behalf has, (i) taken, directly or indirectly, any action designed to cause or to result in the stabilization or manipulation of the price of any security of the Company to facilitate the sale or resale of any of the Shares, (ii) sold, bid for, purchased, or, paid any compensation for soliciting purchases of, any of the Shares, or (iii) paid or agreed to pay to any Person any compensation for soliciting another to purchase any other securities of the Company.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(hh)<u>Clinical Data and Regulatory Compliance; Compliance with Health Care Laws</u>.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)The Company has submitted and possesses, or qualifies for applicable exemptions to, such valid and current registrations, listings, approvals, clearances, licenses, classifications, exemptions, certificates, authorizations or permits and supplements or amendments thereto issued or required by the appropriate governmental authority or designated organization necessary to conduct its business ("<u>Permits</u>"), including, without limitation, all such Permits required by the U.S. Food and Drug Administration (the "<u>FDA</u>"), the U.S. Department of Health and Human Services ("<u>HHS</u>"), the U.S. Centers for Medicare & Medicaid Services ("<u>CMS</u>"), state Medicaid agencies, European Union member state national competent authorities ("<u>NCAs</u>") or any other comparable local, state, federal or foreign agencies or bodies to which it is subject, and the Company has not received any notice of proceedings relating to the revocation or modification of, or material non-compliance with, any such Permit. The studies, tests and preclinical and clinical trials and investigations conducted by or on behalf of, or sponsored by, the Company, or in which the Company has participated, that are described in the SEC Reports, or the results of which are referred to in the SEC Reports, were and, if still pending, are being conducted in all material respects in accordance with all applicable Health Care Laws, standard medical and scientific research procedures and any applicable rules, regulations and policies of the jurisdiction in which such trials, studies and investigations are being conducted; the descriptions of the results of such studies, tests, trials and investigations contained in the SEC Reports are accurate and complete descriptions in all material respects and fairly present the data therefrom; the Company has no knowledge of any studies, tests, trials or investigations not described in the SEC Reports, the results of which are inconsistent with or reasonably call into question the results of the studies, tests, trials and investigations described in the SEC Reports; the Company has not received any notices or other correspondence from the FDA, the European Union NCAs, or any other applicable foreign, state or local governmental body exercising comparable authority or any Institutional Review Board or ethics committee or comparable authority or designated organization requiring or threatening the termination, suspension or material modification of any studies, tests or preclinical or clinical trials or investigations conducted by or on behalf of, or sponsored by, the Company or in which the Company has participated, and, to the Company's knowledge, there are no reasonable grounds for the same; and no investigational device exemption or comparable submission filed by or on behalf of the Company has been terminated or suspended by the FDA or any other applicable governmental authority.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)The Company, its directors, employees and, to the Company's knowledge, its agents are and at all times have been in material compliance with, all health care laws applicable to the Company, its products and activities, including, without limitation and to the extent applicable, (A) all foreign, federal, state, and local healthcare related-fraud and abuse, anti-kickback, self-referral, and false claims laws, including the federal Anti-Kickback Statute (42 U.S.C. Section 1320a-7b(b)), the Civil Monetary Penalties Law (42 U.S.C. § 1320a-7a), the civil False Claims Act (31 U.S.C. Section 3729 et seq.), the criminal False Claims Law (42 U.S.C. Section 1320a-7b(a)), the exclusion laws (42 U.S.C. Section 1320a-7), Physician Payments Sunshine Act (42 U.S.C. § 1320a-7h), all criminal laws relating to health care fraud and abuse, including, but not limited to, 18 U.S.C. §§ 286, 287, 1001 and 1349, and the health care fraud criminal provisions under the U.S. Health Insurance Portability and Accountability Act of 1996 (42 U.S.C. Section 1320d et seq.) ("<u>HIPAA</u>"), (B) HIPAA, as amended by the Health Information Technology for Economic and Clinical Health Act (42 U.S.C. Section 17921 et seq.), (C) the Federal Food, Drug, and Cosmetic Act (21 U.S.C. Section 301 et seq.), (D) Medicare (Title XVIII of the Social Security Act), (E) Medicaid (Title XIX of the Social Security Act), (F), in the case

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of each of the foregoing clauses, as amended and together with the regulations promulgated pursuant to such laws, and (G) any other local, state, federal or foreign law, accreditation standards, regulation, memorandum, opinion letter, or other issuance which imposes requirements on manufacturing, development, testing, labeling, advertising, marketing, promotion, distribution, reporting, kickbacks, patient or program charges, recordkeeping, claims process, documentation requirements, medical necessity, referrals, the hiring of employees, contracting of independent contractors or acquisition of services or supplies from those who have been excluded from government health care programs, quality, safety, privacy, security, licensure, accreditation or any other aspect of the research, design, testing, development, sale, marketing, promotion, advertising, ownership, manufacture, packaging, processing, use, distribution, storage, or disposal of medical devices and healthcare items and services (collectively, "<u>Health Care Laws</u>"). The Company has not received any notification, correspondence or any other written or oral communication, including notification of any pending or threatened claim, suit, proceeding, hearing, enforcement, investigation, arbitration or other action from any governmental authority or designated organization, including, without limitation, the FDA, the European Union NCAs, the U.S. Federal Trade Commission, CMS, stated Medicaid agencies, HHS's Office of Inspector General, the U.S. Department of Justice and state Attorneys General or similar agencies or Governmental Authorities, of potential or actual material violation or non-compliance by, or liability of, the Company under any Health Care Laws. To the Company's knowledge, there are no facts or circumstances that would reasonably be expected to give rise to material liability of the Company under any Health Care Laws. The Company is not a party to, and has no ongoing reporting obligations pursuant to, any corporate integrity agreements, deferred prosecution agreements, monitoring agreements, consent decrees, settlement orders, plans of correction or similar agreements with or imposed by any governmental authority. Additionally, neither the Company nor any of its employees, officers, directors, or, to the knowledge of the Company, agents, has been excluded, suspended or debarred from participation in any government health care program or human research study, clinical trial or investigation or, to the knowledge of the Company, is subject to an inquiry, investigation, proceeding, or other similar action by any government authority that would reasonably be expected to result in debarment, suspension, or exclusion.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)<u>Office of Foreign Assets Control</u>. Neither the Company nor any Subsidiary nor, to the Company's knowledge, any director, officer, agent, employee or affiliate of the Company or any Subsidiary is currently subject to any U.S. sanctions administered by the Office of Foreign Assets Control of the U.S. Treasury Department.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(jj)<u>Money Laundering</u>. The operations of the Company and its Subsidiaries are and have been conducted at all times in compliance with applicable financial record-keeping and reporting requirements of the Currency and Foreign Transactions Reporting Act of 1970, as amended, applicable money laundering statutes and applicable rules and regulations thereunder (collectively, the "<u>Money Laundering Laws</u>"), and no Action or Proceeding by or before any court or governmental agency, authority or body or any arbitrator involving the Company or any Subsidiary with respect to the Money Laundering Laws is pending or, to the knowledge of the Company or any Subsidiary, threatened in writing.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.2<u>Representations and Warranties of the Purchasers</u>. Each Purchaser, for itself and for no other Purchaser, hereby represents and warrants as of the date hereof and as of the Closing

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Date to the Company as follows (unless as of a specific date therein, in which case they shall be accurate as of such date):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)<u>Organization; Authority</u>. Such Purchaser is either an individual or an entity duly incorporated or formed, validly existing and in good standing under the laws of the jurisdiction of its incorporation or formation with full right, corporate, partnership, limited liability company or similar power and authority to enter into and to consummate the transactions contemplated by the Transaction Documents and otherwise to carry out its obligations hereunder and thereunder. The execution and delivery of the Transaction Documents and performance by such Purchaser of the transactions contemplated by the Transaction Documents have been duly authorized by all necessary corporate, partnership, limited liability company or similar action, as applicable, on the part of such Purchaser. Each Transaction Document to which it is a party has been duly executed by such Purchaser, and when delivered by such Purchaser in accordance with the terms hereof, will constitute the valid and legally binding obligation of such Purchaser, enforceable against it in accordance with its terms, except: (i) as limited by general equitable principles and applicable bankruptcy, insolvency, reorganization, moratorium and other laws of general application affecting enforcement of creditors' rights generally, (ii) as limited by laws relating to the availability of specific performance, injunctive relief or other equitable remedies and (iii) insofar as indemnification and contribution provisions may be limited by applicable law.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)<u>Understandings or Arrangements</u>. Such Purchaser is acquiring the Shares as principal for its own account and has no direct or indirect arrangement or understandings with any other persons to distribute or regarding the distribution of such Shares (this representation and warranty not limiting such Purchaser's right to sell the Shares pursuant to the Registration Statement or otherwise in compliance with applicable federal and state securities laws). Such Purchaser is acquiring the Shares hereunder in the ordinary course of its business.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)<u>[Reserved]</u>.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)<u>Experience of Such Purchaser</u>. Such Purchaser, either alone or together with its representatives, has such knowledge, sophistication and experience in business and financial matters so as to be capable of evaluating the merits and risks of the prospective investment in the Shares, and has so evaluated the merits and risks of such investment. Such Purchaser is able to bear the economic risk of an investment in the Shares and, at the present time, is able to afford a complete loss of such investment.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e)<u>Access to Information</u>. Such Purchaser acknowledges that it has had the opportunity to review the Transaction Documents (including all exhibits and schedules thereto) and the SEC Reports and has been afforded, (i) the opportunity to ask such questions as it has deemed necessary of, and to receive answers from, representatives of the Company concerning the terms and conditions of the offering of the Shares and the merits and risks of investing in the Shares; (ii) access to information about the Company and its financial condition, results of operations, business, properties, management and prospects sufficient to enable it to evaluate its investment; and (iii) the opportunity to obtain such additional

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information that the Company possesses or can acquire without unreasonable effort or expense that is necessary to make an informed investment decision with respect to the investment.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f)<u>Certain Transactions and Confidentiality</u>. Other than consummating the transactions contemplated hereunder, such Purchaser has not, nor has any Person acting on behalf of or pursuant to any understanding with such Purchaser, directly or indirectly executed any purchases or sales, including Short Sales, of the securities of the Company during the period commencing as of the time that such Purchaser first received a notice of the transaction contemplated hereunder (written or oral) from the Company or any other Person representing the Company and ending immediately prior to the execution hereof. Notwithstanding the foregoing, in the case of a Purchaser that is a multi-managed investment vehicle whereby separate portfolio managers manage separate portions of such Purchaser's assets and the portfolio managers have no direct knowledge of the investment decisions made by the portfolio managers managing other portions of such Purchaser's assets, the representation set forth above shall only apply with respect to the portion of assets managed by the portfolio manager that made the investment decision to purchase the Securities covered by this Agreement. Other than to other Persons party to this Agreement or to such Purchaser's representatives that are bound by confidentiality obligations, including, without limitation, its officers, directors, partners, legal and other advisors, employees, agents and Affiliates, such Purchaser has maintained the confidentiality of all disclosures made to it in connection with this transaction (including the existence and terms of this transaction). Notwithstanding the foregoing, for the avoidance of doubt, nothing contained herein shall constitute a representation or warranty, or preclude any actions, with respect to locating or borrowing shares in order to effect Short Sales or similar transactions in the future.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g)<u>[Reserved]</u>.

The Company acknowledges and agrees that the representations contained in this Section 3.2 shall not modify, amend or affect such Purchaser's right to rely on the Company's representations and warranties contained in this Agreement or any representations and warranties contained in any other Transaction Document or any other document or instrument executed and/or delivered in connection with this Agreement or the consummation of the transactions contemplated hereby. Notwithstanding the foregoing, for the avoidance of doubt, nothing contained herein shall constitute a representation or warranty, or preclude any actions, with respect to locating or borrowing shares in order to effect Short Sales or similar transactions in the future.

**ARTICLE IV.**

OTHER AGREEMENTS OF THE PARTIES

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.1<u>Legends</u>. The Shares shall be issued free of legends and shall not be subject to restrictions on transfer or resale under US federal or state securities laws or be subject to stop transfer instructions.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.2<u>Integration</u>. The Company shall not sell, offer for sale or solicit offers to buy or otherwise negotiate in respect of any security (as defined in Section 2 of the Securities Act) that would be integrated with the offer or sale of the Shares in a manner that would be integrated with the offer or sale of the Shares for purposes of the rules and regulations of any Trading Market such

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that it would require shareholder approval prior to the closing of such other transaction unless shareholder approval is obtained before the closing of such subsequent transaction.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.3<u>Securities Laws Disclosure; Publicity</u>. The Company shall (a) by the Disclosure Time, issue a press release disclosing the material terms of the transactions contemplated hereby and otherwise publicly disseminate the information on <u>Schedule A</u>, and (b) file a Report on Form 6-K, including the Transaction Documents as exhibits thereto, with the Commission within the time required by the Exchange Act. From and after the issuance of such press release and the dissemination of the information set forth on <u>Schedule A</u> hereto, the Company represents to the Purchasers that it shall have publicly disclosed all material, non-public information delivered to any of the Purchasers by the Company or any of its Subsidiaries, or any of their respective officers, directors, employees or agents in connection with the transactions contemplated by the Transaction Documents. In addition, effective upon the issuance of such press release, the Company acknowledges and agrees that any and all confidentiality or similar obligations under any agreement, whether written or oral, between the Company, any of its Subsidiaries or any of their respective officers, directors, agents, employees or Affiliates on the one hand, and any of the Purchasers or any of their Affiliates on the other hand, shall terminate. Notwithstanding the foregoing, the Company shall not publicly disclose the name of any Purchaser (or any of its Affiliates), nor include the name of any Purchaser in any filing with the Commission or any regulatory agency or Trading Market, in each case without the prior written consent of such Purchaser, except (a) as required by federal securities law in connection with the filing of final Transaction Documents with the Commission and (b) to the extent such disclosure is required by law or Trading Market regulations, in which case the Company shall, to the extent permitted by law, provide the applicable Purchasers with prior notice of such disclosure permitted under this clause (b) and a reasonable opportunity to review and comment.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.4<u>Shareholder Rights Plan</u>. No claim will be made or enforced by the Company or, with the consent of the Company, any other Person, that any Purchaser is an "<u>Acquiring Person</u>" under any control share acquisition, business combination, poison pill (including any distribution under a rights agreement) or similar anti-takeover plan or arrangement in effect or hereafter adopted by the Company, or that any Purchaser could be deemed to trigger the provisions of any such plan or arrangement, by virtue of receiving Securities under the Transaction Documents or under any other agreement between the Company and the Purchasers.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.5<u>Non-Public Information</u>. Except with respect to the material terms and conditions of the transactions contemplated by the Transaction Documents, which shall be disclosed pursuant to Section 4.3, the Company covenants and agrees that neither the Company, nor any other Person acting on its behalf will provide any Purchaser or its agents or counsel with any information that constitutes, or the Company reasonably believes constitutes, material non-public information, unless prior thereto such Purchaser shall have consented to the receipt of such information and agreed with the Company to keep such information confidential. The Company understands and confirms that each Purchaser shall be relying on the foregoing covenant in effecting transactions in securities of the Company. To the extent that the Company delivers any material, non-public information to a Purchaser without such Purchaser's consent, the Company hereby covenants and agrees that such Purchaser shall not have any duty of confidentiality to the Company, any of its Subsidiaries, or any of their respective officers, directors, agents, employees or Affiliates, or a duty to the Company, any of its Subsidiaries or any of their respective officers, directors, agents,

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employees or Affiliates not to trade on the basis of, such material, non-public information, provided that the Purchaser shall remain subject to applicable law. Unless otherwise agreed to by the applicable parties, to the extent that any notice provided pursuant to any Transaction Document constitutes, or contains, material, non-public information regarding the Company or any Subsidiaries, the Company shall simultaneously file such material, non-public information with the Commission pursuant to a Report on Form 6-K. The Company understands and confirms that each Purchaser shall be relying on the foregoing covenant in effecting transactions in securities of the Company.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.6<u>Use of Proceeds</u>. The Company intends to use the net proceeds from the sale of the Shares hereunder for working capital purposes and other general corporate purposes.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.7<u>Indemnification of Purchasers</u>. Subject to the provisions of this Section 4.7, the Company will indemnify and hold each Purchaser and its directors, officers, shareholders, members, partners, employees and agents (and any other Persons with a functionally equivalent role of a Person holding such titles notwithstanding a lack of such title or any other title), each Person who controls such Purchaser (within the meaning of Section 15 of the Securities Act and Section 20 of the Exchange Act), and the directors, officers, shareholders, agents, members, partners or employees (and any other Persons with a functionally equivalent role of a Person holding such titles notwithstanding a lack of such title or any other title) of such controlling persons (each, a "<u>Purchaser Party</u>") harmless from any and all losses, liabilities, obligations, claims, contingencies, damages, costs and expenses, including all judgments, amounts paid in settlements, court costs and reasonable attorneys' fees and costs of investigation that any such Purchaser Party may suffer or incur as a result of or relating to (a) any breach of any of the representations, warranties, covenants or agreements made by the Company in this Agreement or in the other Transaction Documents, (b) any action instituted against the Purchaser Parties in any capacity, or any of them or their respective Affiliates, by any stockholder of the Company who is not an Affiliate of such Purchaser Party, with respect to any of the transactions contemplated by the Transaction Documents (unless such action is solely based upon a material breach of such Purchaser Party's representations, warranties or covenants under the Transaction Documents or any agreements or understandings such Purchaser Party may have with any such stockholder or any violations by such Purchaser Party of state or federal securities laws or any conduct by such Purchaser Party which is finally judicially determined to constitute fraud, gross negligence or willful misconduct). If any action shall be brought against any Purchaser Party in respect of which indemnity may be sought pursuant to this Agreement, such Purchaser Party shall promptly notify the Company in writing, and the Company shall have the right to assume the defense thereof with counsel of its own choosing reasonably acceptable to the Purchaser Party. Any Purchaser Party shall have the right to employ separate counsel in any such action and participate in the defense thereof, but the fees and expenses of such counsel shall be at the expense of such Purchaser Party except to the extent that (x) the employment thereof has been specifically authorized by the Company in writing, (y) the Company has failed after a reasonable period of time to assume such defense and to employ counsel or (z) in such action there is, in the reasonable opinion of counsel, a material conflict on any material issue between the position of the Company and the position of such Purchaser Party, in which case the Company shall be responsible for the reasonable fees and expenses of no more than one such separate counsel. The Company will not be liable to any Purchaser Party under this Agreement (1) for any settlement by a Purchaser Party effected without the Company's prior written consent, which shall not be unreasonably withheld or delayed; or (2)

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to the extent, but only to the extent that a loss, claim, damage or liability is attributable to any Purchaser Party's breach of any of the representations, warranties, covenants or agreements made by such Purchaser Party in this Agreement or in the other Transaction Documents. The indemnity agreements contained herein shall be in addition to any cause of action or similar right of any Purchaser Party against the Company or others and any liabilities the Company may be subject to pursuant to law.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.8<u>Listing of</u> <u>Ordinary Shares</u>. The Company hereby agrees to use commercially reasonable efforts to maintain the listing or quotation of the Ordinary Shares on the Trading Market on which it is currently listed, and (i) concurrently with the Closing, the Company shall apply to list or quote all of the Shares on the Nasdaq Global Market and (ii) on or around the date of the Closing, the Company shall apply to list or quote all of the Shares on Euronext Brussels and promptly secure the listing of all of the Shares on the applicable Trading Market. The Company further agrees, if the Company applies to have the Ordinary Shares traded on any other Trading Market, it will then include in such application all of the Shares, and will take such other action as is reasonably necessary to cause all of the Shares to be listed or quoted on such other Trading Market as promptly as possible. The Company will then take all action reasonably necessary to continue the listing and trading of Shares on a Trading Market and will comply in all respects with the Company's reporting, filing and other obligations of which it has control under the bylaws or rules of the Trading Market. The Company agrees to maintain the eligibility of the Ordinary Shares for electronic transfer through the Depository Trust Company or another established clearing corporation, including, without limitation, by timely payment of fees to the Depository Trust Company or such other established clearing corporation in connection with such electronic transfer.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.9<u>Subsequent Equity Sales</u>.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)From the date hereof until thirty (30) days after the date of the Prospectus Supplement, neither the Company nor any Subsidiary shall issue, enter into any agreement to issue or announce the issuance or proposed issuance of any Ordinary Shares or Ordinary Share Equivalents or file any registration statement or amendment or supplement thereto, other than (i) the Prospectus Supplement or (ii) filing amendments or supplements to registration statements filed prior to the date of this Agreement so long as no new securities are registered on any such existing registration statements.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)Notwithstanding the foregoing, this Section 4.9 shall not apply in respect of an Exempt Issuance or any of the transactions set forth on <u>Schedule A</u> hereto.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.10<u>Certain Transactions and Confidentiality</u>. Each Purchaser, severally and not jointly with the other Purchasers, covenants that neither it nor any Affiliate acting on its behalf or pursuant to any understanding with it will execute any purchases or sales, including Short Sales of any of the Company's securities during the period commencing with the execution of this Agreement and ending at such time that the transactions contemplated by this Agreement are first publicly announced pursuant to the initial press release as described in Section 4.3. Each Purchaser, severally and not jointly with the other Purchasers, covenants that until such time as the transactions contemplated by this Agreement are publicly disclosed by the Company pursuant to the initial press release as described in Section 4.3, such Purchaser will maintain the confidentiality

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of the existence and terms of this transaction and any other information provided to such Purchaser in connection with this transaction (other than as disclosed to its legal and other representatives). Notwithstanding the foregoing, and notwithstanding anything contained in this Agreement to the contrary, the Company expressly acknowledges and agrees that (i) no Purchaser makes any representation, warranty or covenant hereby that it will not engage in effecting transactions in any securities of the Company after the time that the transactions contemplated by this Agreement are first publicly announced pursuant to the initial press release as described in Section 4.3, (ii) no Purchaser shall be restricted or prohibited from effecting any transactions in any securities of the Company in accordance with applicable securities laws from and after the time that the transactions contemplated by this Agreement are first publicly announced pursuant to the initial press release as described in Section 4.3 and (iii) no Purchaser shall have any duty of confidentiality or duty not to trade in the securities of the Company to the Company or its Subsidiaries after the issuance of the initial press release as described in Section 4.3. Notwithstanding the foregoing, in the case of a Purchaser that is a multi-managed investment vehicle whereby separate portfolio managers manage separate portions of such Purchaser's assets and the portfolio managers have no direct knowledge of the investment decisions made by the portfolio managers managing other portions of such Purchaser's assets, the covenant set forth above shall only apply with respect to the portion of assets managed by the portfolio manager that made the investment decision to purchase the Shares covered by this Agreement.

**ARTICLE V.**

MISCELLANEOUS

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.1<u>Termination</u>. This Agreement may be terminated by (i) any Purchaser, as to such Purchaser's obligations hereunder only and without any effect whatsoever on the obligations between the Company and the other Purchasers, by written notice to the other parties, or (ii) by the Company, by written notice to the Purchasers, if in either case, if the Closing has not been consummated on or before the fifth (5<sup>th</sup>) Trading Day following the date hereof; <u>provided</u>, <u>however</u>, that no such termination will affect the right of any party to sue for any breach by any other party (or parties).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.2<u>Fees and Expenses</u>. Except as expressly set forth in the Transaction Documents to the contrary, each party shall pay the fees and expenses of its advisers, counsel, accountants and other experts, if any, and all other expenses incurred by such party incident to the negotiation, preparation, execution, delivery and performance of this Agreement. The Company shall pay all Transfer Agent fees (including, without limitation, any fees required for same-day processing of any instruction letter delivered by the Company)), stamp taxes and other taxes and duties levied in connection with the delivery of any Shares to the Purchasers and shall reimburse the Purchasers for any fees charged to Purchasers.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.3<u>Entire Agreement</u>. The Transaction Documents, together with the exhibits and schedules thereto, the Prospectus and the Prospectus Supplement, contain the entire understanding of the parties with respect to the subject matter hereof and thereof and supersede all prior agreements and understandings, oral or written, with respect to such matters, which the parties acknowledge have been merged into such documents, exhibits and schedules.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.4<u>Notices</u>. Any and all notices or other communications or deliveries required or permitted to be provided hereunder shall be in writing and shall be deemed given and effective on the earliest of: (a) the time of transmission, if such notice or communication is delivered via email attachment at the email address as set forth on the signature pages attached hereto at or prior to 5:30 p.m. (New York City time) on a Trading Day, (b) the next Trading Day after the time of transmission, if such notice or communication is delivered via email attachment at the email address as set forth on the signature pages attached hereto on a day that is not a Trading Day or later than 5:30 p.m. (New York City time) on any Trading Day, (c) the second (2<sup>nd</sup>) Trading Day following the date of mailing, if sent by U.S. nationally recognized overnight courier service or (d) upon actual receipt by the party to whom such notice is required to be given. The address for such notices and communications shall be as set forth on the signature pages attached hereto. To the extent that any notice provided pursuant to any Transaction Document constitutes, or contains, material, non-public information regarding the Company or any Subsidiaries, the Company shall simultaneously file such notice with the Commission pursuant to a Report on Form 6-K.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.5<u>Amendments; Waivers</u>. No provision of this Agreement may be waived, modified, supplemented or amended except in a written instrument signed, in the case of an amendment, by the Company and Purchasers who purchased at least 50.1% in interest of the Shares, voting together as a single class, based on the initial Subscription Amounts hereunder (or, prior to the Closing Date, the Company and each Purchaser) or, in the case of a waiver, by the party against whom enforcement of any such waived provision is sought, provided that if any amendment, modification or waiver disproportionately and adversely impacts a Purchaser (or group of Purchasers), the consent of such disproportionately impacted Purchaser (or group of Purchasers) shall also be required (except that prior to the Closing, the consent of each such disproportionately impacted Purchaser shall also be required). No waiver of any default with respect to any provision, condition or requirement of this Agreement shall be deemed to be a continuing waiver in the future or a waiver of any subsequent default or a waiver of any other provision, condition or requirement hereof except to the extent expressly stated in such waiver, nor shall any delay or omission of any party to exercise any right hereunder in any manner impair the exercise of any such right. Any proposed amendment or waiver that disproportionately, materially and adversely affects the rights and obligations of any Purchaser relative to the comparable rights and obligations of the other Purchasers shall require the prior written consent of such adversely affected Purchaser. Any amendment effected in accordance with this Section 5.5 shall be binding upon each Purchaser and holder of Shares and the Company.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.6<u>Headings</u>. The headings herein are for convenience only, do not constitute a part of this Agreement and shall not be deemed to limit or affect any of the provisions hereof.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.7<u>Successors and Assigns</u>. This Agreement shall be binding upon and inure to the benefit of the parties and their successors and permitted assigns. The Company may not assign this Agreement or any rights or obligations hereunder without the prior written consent of each Purchaser (other than by merger, consolidation, spin off or any similar transaction). Any Purchaser may assign any or all of its rights under this Agreement to any Person to whom such Purchaser assigns or transfers any Shares, provided that such transferee agrees in writing to be bound, with respect to the transferred Shares, by the provisions of the Transaction Documents that apply to the "Purchasers."

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.8<u>No Third-Party Beneficiaries</u>. This Agreement is intended for the benefit of the parties hereto and their respective successors and permitted assigns and is not for the benefit of, nor may any provision hereof be enforced by, any other Person, except as otherwise set forth in Section 4.8 and this Section 5.8.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.9<u>Governing Law</u>. All questions concerning the construction, validity, enforcement and interpretation of the Transaction Documents shall be governed by and construed and enforced in accordance with the internal laws of the State of New York, without regard to the principles of conflicts of law thereof. Each party agrees that all legal Proceedings concerning the interpretations, enforcement and defense of the transactions contemplated by this Agreement and any other Transaction Documents (whether brought against a party hereto or its respective affiliates, directors, officers, shareholders, partners, members, employees or agents) shall be commenced exclusively in the state and federal courts sitting in the City of New York. Each party hereby irrevocably submits to the exclusive jurisdiction of the state and federal courts sitting in the City of New York, Borough of Manhattan for the adjudication of any dispute hereunder or in connection herewith or with any transaction contemplated hereby or discussed herein (including with respect to the enforcement of any of the Transaction Documents), and hereby irrevocably waives, and agrees not to assert in any Action or Proceeding, any claim that it is not personally subject to the jurisdiction of any such court, that such Action or Proceeding is improper or is an inconvenient venue for such Proceeding. Each party hereby irrevocably waives personal service of process and consents to process being served in any such Action or Proceeding by mailing a copy thereof via registered or certified mail or overnight delivery (with evidence of delivery) to such party at the address in effect for notices to it under this Agreement and agrees that such service shall constitute good and sufficient service of process and notice thereof. Nothing contained herein shall be deemed to limit in any way any right to serve process in any other manner permitted by law. If any party shall commence an Action or Proceeding to enforce any provisions of the Transaction Documents, then, in addition to the obligations of the Company under Section 4.7, the prevailing party in such Action or Proceeding shall be reimbursed by the non-prevailing party for its reasonable attorneys' fees and other costs and expenses incurred with the investigation, preparation and prosecution of such Action or Proceeding.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.10<u>Survival</u>. The representations and warranties contained herein shall survive the Closing and the delivery of the Shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.11<u>Execution</u>. This Agreement may be executed in two or more counterparts, all of which when taken together shall be considered one and the same agreement and shall become effective when counterparts have been signed by each party and delivered to each other party, it being understood that the parties need not sign the same counterpart. In the event that any signature is delivered by e-mail delivery of a ".pdf" format data file (or any electronic signature complying with the U.S. federal ESIGN Act of 2000, the Uniform Electronic Transactions Act or other applicable law (e.g., www.docusign.com), such signature shall create a valid and binding obligation of the party executing (or on whose behalf such signature is executed) with the same force and effect as if such ".pdf" or "electronic" signature page were an original thereof.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.12<u>Severability</u>. If any term, provision, covenant or restriction of this Agreement is held by a court of competent jurisdiction to be invalid, illegal, void or unenforceable, the remainder of the terms, provisions, covenants and restrictions set forth herein shall remain in full force and

------

effect and shall in no way be affected, impaired or invalidated, and the parties hereto shall use their commercially reasonable efforts to find and employ an alternative means to achieve the same or substantially the same result as that contemplated by such term, provision, covenant or restriction. It is hereby stipulated and declared to be the intention of the parties that they would have executed the remaining terms, provisions, covenants and restrictions without including any of such that may be hereafter declared invalid, illegal, void or unenforceable.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.13<u>Rescission and Withdrawal Right</u>. Notwithstanding anything to the contrary contained in (and without limiting any similar provisions of) any of the other Transaction Documents, whenever any Purchaser exercises a right, election, demand or option under a Transaction Document and the Company does not timely perform its related obligations within the periods therein provided, then such Purchaser may rescind or withdraw, in its sole discretion from time to time upon written notice to the Company, any relevant notice, demand or election in whole or in part without prejudice to its future actions and rights.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.14<u>Replacement of Securities</u>. If any certificate or instrument evidencing any Securities is mutilated, lost, stolen or destroyed, the Company shall issue or cause to be issued in exchange and substitution for and upon cancellation thereof (in the case of mutilation), or in lieu of and substitution therefor, a new certificate or instrument, but only upon receipt of evidence reasonably satisfactory to the Company of such loss, theft or destruction. The applicant for a new certificate or instrument under such circumstances shall also pay any reasonable third-party costs (including customary indemnity) associated with the issuance of such replacement Shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.15<u>Remedies</u>. In addition to being entitled to exercise all rights provided herein or granted by law, including recovery of damages, each of the Purchasers and the Company will be entitled to specific performance under the Transaction Documents. The parties agree that monetary damages may not be adequate compensation for any loss incurred by reason of any breach of obligations contained in the Transaction Documents and hereby agree to waive and not to assert in any Action for specific performance of any such obligation the defense that a remedy at law would be adequate.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.16<u>Payment Set Aside</u>. To the extent that the Company makes a payment or payments to any Purchaser pursuant to any Transaction Document or a Purchaser enforces or exercises its rights thereunder, and such payment or payments or the proceeds of such enforcement or exercise or any part thereof are subsequently invalidated, declared to be fraudulent or preferential, set aside, recovered from, disgorged by or are required to be refunded, repaid or otherwise restored to the Company, a trustee, receiver or any other Person under any law (including, without limitation, any bankruptcy law, state or federal law, common law or equitable cause of action), then to the extent of any such restoration the obligation or part thereof originally intended to be satisfied shall be revived and continued in full force and effect as if such payment had not been made or such enforcement or setoff had not occurred.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.17<u>Independent Nature of Purchasers' Obligations and Rights</u>. The obligations of each Purchaser under any Transaction Document are several and not joint with the obligations of any other Purchaser, and no Purchaser shall be responsible in any way for the performance or non-performance of the obligations of any other Purchaser under any Transaction Document. Nothing contained herein or in any other Transaction Document, and no action taken by any Purchaser

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pursuant hereto or thereto, shall be deemed to constitute the Purchasers as a partnership, an association, a joint venture or any other kind of entity, or create a presumption that the Purchasers are in any way acting in concert or as a group with respect to such obligations or the transactions contemplated by the Transaction Documents. Each Purchaser shall be entitled to independently protect and enforce its rights including, without limitation, the rights arising out of this Agreement or out of the other Transaction Documents, and it shall not be necessary for any other Purchaser to be joined as an additional party in any Proceeding for such purpose. Each Purchaser has been represented by its own separate legal counsel in its review and negotiation of the Transaction Documents. The Company has elected to provide all Purchasers with the same terms and Transaction Documents for the convenience of the Company and not because it was required or requested to do so by any of the Purchasers. It is expressly understood and agreed that each provision contained in this Agreement and in each other Transaction Document is between the Company and a Purchaser, solely, and not between the Company and the Purchasers collectively and not between and among the Purchasers.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.18<u>Saturdays, Sundays, Holidays, etc.</u> If the last or appointed day for the taking of any action or the expiration of any right required or granted herein shall not be a Business Day, then such action may be taken or such right may be exercised on the next succeeding Business Day.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.19<u>Construction</u>. The parties agree that each of them and/or their respective counsel have reviewed and had an opportunity to revise the Transaction Documents and, therefore, the normal rule of construction to the effect that any ambiguities are to be resolved against the drafting party shall not be employed in the interpretation of the Transaction Documents or any amendments thereto. In addition, each and every reference to share prices, Ordinary Shares in any Transaction Document shall be subject to adjustment for reverse and forward stock splits, stock dividends, stock combinations, reclassification and other similar transactions of the Ordinary Shares that occur after the date of this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.20**WAIVER OF JURY TRIAL. IN ANY ACTION, SUIT, OR PROCEEDING IN ANY JURISDICTION BROUGHT BY ANY PARTY AGAINST ANY OTHER PARTY, THE PARTIES EACH KNOWINGLY AND INTENTIONALLY, TO THE GREATEST EXTENT PERMITTED BY APPLICABLE LAW, HEREBY ABSOLUTELY, UNCONDITIONALLY, IRREVOCABLY AND EXPRESSLY WAIVES FOREVER TRIAL BY JURY.**

*(Signature Pages Follow)*

------

IN WITNESS WHEREOF, the parties hereto have caused this Securities Purchase Agreement to be duly executed by their respective authorized signatories as of the date first indicated above.

---

| | | |
|:---|:---|:---|
| **NYXOAH SA** | **NYXOAH SA** | <u>Address for Notice:</u>  |
|  |  | Rue Edouard Belin 12 |
|  |  | Mont-Saint |
|  |  | Guibert Belgium |
| By: |  |  |
|  | Name: | E-Mail: |
|  | Title: |  |
| With a copy to (which shall not constitute notice): | With a copy to (which shall not constitute notice): |  |

---

[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK

SIGNATURE PAGE FOR PURCHASER FOLLOWS]

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[PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT]

IN WITNESS WHEREOF, the undersigned have caused this Securities Purchase Agreement to be duly executed by their respective authorized signatories as of the date first indicated above.

---

| |
|:---|
| Name of Purchaser: |
| *Signature of Authorized Signatory of Purchaser*: |
| Name of Authorized Signatory: |
| Title of Authorized Signatory: |
| Email Address of Authorized Signatory: |
| Facsimile Number of Authorized Signatory: |
| Address for Notice to Purchaser: |
| DWAC for Ordinary Shares: |
| Subscription Amount: $ |
| Ordinary Shares: |
| EIN Number: |

---

[SIGNATURE PAGES CONTINUE]

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## Exhibit 4.20

**Exhibit 4.20**

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**Dated 13 November 2025**

**Subscription Agreement**

in respect of the commitment to subscribe and the issuance of €-denominated Amortising Senior Unsecured Convertible Bonds

between

**Nyxoah SA**

as Issuer

**CVI Investments, Inc.**

as Initial Subscriber

White & Case LLP

5 Old Broad Street

London EC2N 1DW

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**Table of Contents**

---

| | | |
|:---|:---|:---|
|  |  | **Page** |
| 1. | Definitions and Interpretation | 2 |
| 2. | Issue and Subscription of the First Tranche Bonds | 9 |
| 3. | Completion and Settlement | 10 |
| 4. | Issue and Subscription of the Second Tranche Bonds | 12 |
| 5. | Indemnification of the Initial Subscriber | 16 |
| 6. | Costs and Expenses | 18 |
| 7. | Representations and Warranties of the Issuer | 19 |
| 8. | Representations of the Initial Subscriber | 31 |
| 9. | Undertakings by the Issuer | 32 |
| 10. | Notices | 34 |
| 11. | Confidential Information | 35 |
| 12. | Payments | 36 |
| 13. | Set-off and Counterclaims | 36 |
| 14. | Severability | 36 |
| 15. | Remedies and Waivers | 37 |
| 16. | Assignment and Transfers | 37 |
| 17. | Survival | 37 |
| 18. | Amendments and Waivers | 37 |
| 19. | Counterparts | 37 |
| 20. | Governing Law and Jurisdiction | 38 |

---

---

| | | |
|:---|:---|:---|
| **Schedule 1** | **First Tranche Conditions Precedent** | **39** |
| **Schedule 2** | **Second Tranche Conditions Precedent** | **41** |
| **Schedule 3** | **Form of Second Tranche Request Notice** | **43** |
| **Schedule 4** | **Form of Corporate Certificate** | **44** |
| **Schedule 5** | **Form of Closing Certificate** | **46** |

---

(i) ------

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**This Agreement** is made on 13 November 2025

**Between:**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) **Nyxoah SA**, a public limited liability company incorporated and existing under the laws of Belgium, registered with the Crossroads Bank for Enterprises (Kruispuntbank van Ondernemingen/Banque-Carrefour des Entreprises) under number 0817149675 (Register of Legal Entities Brabant Wallon), whose registered office is at Rue Edouard Belin 12, 1435 Mont-Saint-Guibert, Belgium (the "**Issuer** "); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) **CVI INVESTMENTS INC.**, a Cayman Islands exempted company (the "**Initial Subscriber** "),

(each a "**Party**" and together, the "**Parties**").

**Whereas:**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) The Issuer proposes to issue €22,500,000 amortising senior unsecured convertible bonds due 2028 (the "**First Tranche Bonds**") to be constituted by a bond instrument to be entered into not later than the First Tranche Closing Date (as defined below) by the Issuer (in the agreed form and as may be supplemented or amended from time to time, the "**First Tranche Bond Instrument** "), and subject to the terms and conditions set out in the First Tranche Bond Instrument (in the agreed form) (the "**First Tranche Conditions** ").

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) Prior to the issue of the First Tranche Bonds, the Issuer shall conduct a primary placing of newly issued ordinary shares of the Issuer with no nominal value per share (the "**Shares**") in number resulting in no less than gross proceeds of €20,000,000 (inclusive of the proceeds to be received from the Initial Subscriber in relation to its proposed subscription of such Shares) pursuant to an equity offering by the Issuer, with all such sales of Shares to be at the same placing price (the "**Placing Price**" and the "**Equity Offering** ", respectively). The Initial Subscriber intends to participate in the Equity Offering and subscribe for Shares (at the Placing Price) in number resulting in a gross subscription price of approximately €4,000,000.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(C) Following the First Tranche Closing Date (as defined below), and subject to the terms of this Agreement, the Issuer may create and issue one additional series of amortising senior unsecured convertible bonds, with such series having an aggregate principal amount series of €22,500,000. This additional series will be referred to as the "**Second Tranche Bonds** ", and together with the First Tranche Bonds, they will be collectively referred to as the "**Bonds**" and each a "**Series** ".

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(D) Subject to the provisions of the First Tranche Conditions, the First Tranche Bonds will be convertible into Shares at the Conversion Price (as defined in the First Tranche Conditions), subject to adjustment in accordance with the First Tranche Conditions. Payments of principal instalment amounts and interest amounts on the First Tranche Bonds shall in certain circumstances (subject to and in accordance with the First Tranche Conditions) be settled by the issuance of Shares as provided in the First Tranche Conditions.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(E) The Second Tranche Bonds are intended to be issued on substantially the same terms as the First Tranche Bonds, subject as otherwise provided in this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(F) The Parties hereto wish to record the arrangements agreed between them in relation to the commitment to subscribe for the Bonds of each Series by the Initial Subscriber and the issue of the Bonds of each Series by the Issuer.

------

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**It is agreed:**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**1.** **Definitions and Interpretation** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**1.1** **Definitions** 

In this Agreement, the following terms shall have the following meanings:

"**€**" or "**EUR**" means the euro currency introduced at the start of the third stage of European economic and monetary union, and as defined in Article 2 of Council Regulation (EC) No 974/98 of 3 May 1998 on the introduction of the euro, as amended.

"**affiliate**" has the meaning given to it in Rule 501(b) of Regulation D under the Securities Act.

"**Agreed Expenses**" means any costs and expenses payable by the Issuer in accordance with Clause 6.1(b) (*Costs and Expenses*), but excluding any Deposited Amounts that have been paid by the Issuer prior to the date of this Agreement in accordance with the Term Sheet.

"**Anti-Bribery and Anti-Corruption Laws**" has the meaning given in Clause 7.1(z)(i) (*Representations and Warranties*).

"**Authorisation**" means an authorisation, consent, approval, resolution, licence, exemption, filing, notarisation or registration.

"**Average Market Capitalisation**" means the arithmetic average of the market capitalisation of the Issuer based on the Closing Price (as defined in the First Tranche Conditions) of a Share on each of the 30 consecutive dealing days (as defined in the First Tranche Conditions) ending on (and including) the dealing day immediately preceding the First Tranche Closing Date, as published by or derived from Bloomberg page HP (or any successor page) (setting 'RR902 Current Market Cap', or any other successor setting) (and for the avoidance of doubt as at the date of this Agreement such Bloomberg page for the Shares is NYXH BB Equity HP), as determined by the Calculation Agent, if available or, in any other case, such other source (if any) as shall be agreed in writing (including by email) between the Issuer and the Initial Subscriber (each acting reasonably), and the Market Capitalisation determined as aforesaid on any dealing day shall, if not in EUR, be translated by the Calculation Agent into EUR at the Prevailing Rate (as defined in the First Tranche Conditions) on such dealing day.

"**Belgian Code of Companies and Associations**" means the Belgian Code of Companies and Associations (*Wetboek van vennootschappen en verenigingen*/*Code des sociétés et associations*), a amended from time to time.

"**Bond Documents**" means the First Tranche Bond Documents and the Second Tranche Bond Documents, as the context may require.

"**Bonds**" has the meaning given to it in Recital (B).

"**Business Day**" means a day (other than a Saturday or Sunday) on which banks are open for general non-automated business in Brussels and New York.

"**Calculation Agent**" means Conv-Ex Advisors Limited.

"**Confidential Information**" has the meaning given in Clause 11.1 (*Confidentiality*).

------

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

"**Default**" means an Event of Default or any event or circumstance specified in Condition 10 (*Events of Default*) of the Bonds of each applicable Series which would (with the expiry of a grace period, the giving of notice, the making of any determination under the relevant Bond Documents or any combination of any of the foregoing) be an Event of Default.

"**Deposited Amount**" has the meaning given in the Term Sheet.

"**DTC**" means The Depository Trust Company, a limited purpose trust company organised under the laws of the State of New York, and its successors and assigns.

"**Equity Offering**" has the meaning given to it in Recital (B).

"**Euroclear Belgium**" means Caisse Interprofessionnelle de Dépôts et de Virements de Titres SA/Interprofessionnele Effectendepositen Girokas NV (C.I.K.) (commercial name Euroclear Belgium), enterprise number 0403 206 432 (Register of Legal Entities for Brussels), or any entity replacing the same as a central securities depository.

"**Excluded Instrument**" means any of the following:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the 1,400,000 subscription rights (*inschrijvingsrechten / droits de souscription*) issued by the Issuer on 8 September 2021 pursuant to the 2021 warrants plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the 700,000 subscription rights (*inschrijvingsrechten / droits de souscription*) issued by the Issuer on 28 December 2022 pursuant to the 2022 warrants plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) the 1,000,000 subscription rights (*inschrijvingsrechten / droits de souscription*) issued by the Issuer on 31 July 2024 pursuant to the 2024 warrants plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) the 805,000 subscription rights (*inschrijvingsrechten / droits de souscription*) issued by the Issuer on 30 January 2025 pursuant to the 2025 warrants plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) the 760,000 subscription rights (*inschrijvingsrechten / droits de souscription*) issued by the Issuer on 13 October 2025 pursuant to the 2025-2 warrants plan; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) the subscription rights (*inschrijvingsrechten / droits de souscription*), Shares, or restricted stock units to be issued or granted to directors of personnel of the Issuer (or its affiliates) from time to time in accordance with the remuneration policy of the Issuer, as amended; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) any subscription rights (*inschrijvingsrechten / droits de souscription*) that may be issued from time to time under any other personnel incentive plan,

*provided that,* on any date, (x) the Excluded Instruments, taken together, shall not entitle the beneficiaries thereof the right to subscribe for, acquire, or otherwise receive Shares in an aggregate number exceeding 10.0 per cent. of the Issuer's issued share capital (it being understood that any such subscription rights (*inschrijvingsrechten / droits de souscription*), Shares or restricted stock units issued in excess of the foregoing limitation shall not constitute an Excluded Instrument), and (y) in the case of paragraphs (g) and (h), the issuance of such subscription rights (*inschrijvingsrechten / droits de souscription*), Shares or restricted stock units are issued pursuant to any remuneration policy or other personnel incentive plan that is duly approved by the Issuer's board of directors and (if applicable) its shareholders. Any reference in this Agreement to "**Excluded Instruments**" means all of them.

"**First Tranche Bond Certificate**" means a bond certificate which shall evidence the Initial Subscriber's aggregate holding of First Tranche Bonds in or in substantially the form set out in the

------

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

First Tranche Bond Instrument including any replacement First Tranche Bond Certificate issued pursuant to the terms of the First Tranche Bond Instrument.

"**First Tranche Bond Documents**" means this Agreement, the First Tranche Bond Instrument (including the First Tranche Conditions), the First Tranche Calculation Agency Agreement, each First Tranche Bond Certificate, such other documents relating to the issuance of the First Tranche Bonds as may be designated in writing by the Parties as being a First Tranche Bond Document.

"**First Tranche Bond Instrument**" has the meaning given to it in Recital (A).

"**First Tranche Bonds**" has the meaning given to it in Recital (A).

"**First Tranche Calculation Agency Agreement**" means the calculation agency agreement relating to the First Tranche Bonds (in the agreed form) to be entered into not later than the First Tranche Closing Date between the Issuer and the Calculation Agent (as supplemented or amended from time to time).

"**First Tranche Closing**" means the consummation of the issue of the First Tranche Bonds to the Initial Subscriber.

"**First Tranche Closing Date**" means, in respect of the First Tranche Bonds, 28 November 2025, or such other date as may be agreed in writing (including by email) between the Parties (each acting in its absolute discretion).

"**First Tranche Conditions**" has the meaning given in Recital (A), and any reference to a particular numbered Condition shall be construed accordingly.

"**First Tranche Register**" means the register of First Tranche Bonds maintained by or on behalf of the Issuer in or substantially in the form set out in the First Tranche Bond Instrument.

"**Governmental Authority**" means the government of any nation, or of any political subdivision thereof, whether state, regional or local, and any agency, authority, branch, department, regulatory body, court, central bank or other entity exercising executive, legislative, judicial, taxing, regulatory or administrative powers or functions of or pertaining to government or any subdivision thereof (including any supra-national bodies).

"**IFRS**" means International Financial Reporting Standards issued by the International Accounting Standards Board (IASB) and interpretations issued by the International Reporting Interpretations Committee of the IASB (as amended, supplemented or re-issued from time to time).

"**Indemnified Person**" has the meaning given to it in Clause 5.1(a) (*Indemnity*).

"**Initial Subscriber's Solicitors**" means White & Case LLP, a limited liability partnership organised and existing under the laws of England with its registered office at 5 Old Broad Street, London EC2N 1DW, United Kingdom.

"**Intellectual Property Rights**" means, collectively, trademarks, trade names and other rights to inventions, know-how, patents, copyrights, confidential information and other intellectual property.

"**Last Market Capitalisation**" means the market capitalisation of the Issuer based on the Closing Price (as defined in the First Tranche Conditions) of a Share on the dealing day (as defined in the First Tranche Conditions) immediately preceding the Second Tranche Closing Date, as published by or derived from Bloomberg page HP (or any successor page) (setting 'RR902 Current Market Cap', or any other successor setting) (and for the avoidance of doubt as at the date of this Agreement such Bloomberg page for the Shares is NYXH BB Equity HP), as determined by the Calculation

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Agent, if available or, in any other case, such other source (if any) as shall be agreed in writing (including by email) between the Issuer and the Initial Subscriber (each acting reasonably), and the Market Capitalisation determined as aforesaid on any dealing day shall, if not in EUR, be translated by the Calculation Agent into EUR at the Prevailing Rate (as defined in the First Tranche Conditions) on such dealing day.

"**Licences**" has the meaning given to it in Clause 7.1(q) (*Representations and Warranties*).

"**Material Adverse Change**" means:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) with respect to the Issuer and its Subsidiaries (taken as a whole):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) it is in breach of the terms of, or in default under, any instrument, agreement or order to which it is a party or by which it or its property is bound or an event has occurred which with the giving of notice or lapse of time or other condition would constitute a default under any such instrument, agreement or order, except for any such breach or default which either individually or in the aggregate would not reasonably be expected to be material in the context of the issue and offering of the First Tranche Bonds or the Second Tranche Bonds, as the case may be; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) it is engaged (whether as defendant or otherwise) in, or has knowledge of the existence of, or any threat of, any legal, arbitration, administrative, governmental or other proceedings an adverse result of which would reasonably be expected to be material in the context of the issue and offering of the First Tranche Bonds or the Second Tranche Bonds, as the case may be; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) it has taken any action or any steps have been taken or legal proceedings commenced for the winding up or dissolution of the Issuer or any of its Subsidiaries (other than, in relation to a Subsidiary of the Issuer, as part of a solvent group reorganisation); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) any adverse change or any development or event, in each case when compared to the position which had been publicly disclosed by the Issuer as at the date immediately prior to this Agreement, which would be reasonably expected to, individually or in aggregate, result in a prospective change which is materially adverse to the condition (financial or otherwise), business or general affairs, results of operations, properties or profitability of the Issuer and its Subsidiaries (taken as a whole); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) any development of which the Issuer is, or might reasonably be expected to be, aware that would be reasonably expected to materially adversely affect the ability of the Issuer to consummate the Equity Offering or to perform its respective obligations under the Bond Documents or the Bonds of each Series.

"**Material Adverse Effect**" means (a) any adverse change or any development or event which would be reasonably expected to, individually or in aggregate, result in a prospective change which is materially adverse to the condition (financial or otherwise), business or general affairs, results of operations, properties or profitability of the Issuer and its Subsidiaries (taken as a whole); or (b) any development of which the Issuer is aware that is reasonably likely to materially adversely affect the ability of the Issuer to perform their respective obligations under the Bond Documents or the Bonds of each Series.

"**Money Laundering Laws**" has the meaning given in Clause 7.1(aa) (*Representations and Warranties*).

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"**Placing Price**" has the meaning given in Recital (B).

"**Proceedings**" has the meaning given in Clause 20.2 (*Jurisdiction*).

"**Process Agent**" means the agent for service of process to be appointed by the Issuer in accordance with paragraph 3(e) of Schedule 1 (*First Tranche Conditions Precedent*).

"**Prohibited Payment**" has the meaning given in Clause 7.1(z)(ii) (*Representations and Warranties*).

"**Public Statements**" means any information released to the public by or on behalf of the Issuer or any of its Subsidiaries, whether such information was required to be made public by applicable law and regulation (including, but not limited to, Regulation 596/2014/EU and all disclosures required by the Stock Exchanges or under Belgian or United States laws and regulations) or otherwise, on or after 31 December 2024, as amended or supplemented from time to time.

"**Regulation S**" means Regulation S under the Securities Act.

"**Related Parties**" has the meaning given to it in Clause 5.1(b) (*Indemnity*).

"**Restricted Information**" means any information that is or may be material non-public and price-sensitive or is insider information within the meaning of applicable insider dealing or market abuse law (including Regulation 596/2014/EU).

"**Sanctions**" means any sanctions administered by the Office of Foreign Assets Control of the U.S. Department of Treasury, the U.S. State Department, any other agency of the U.S. government, the United Nations, the European Union or the United Kingdom.

"**Second Tranche Bond Certificate**" means a bond certificate which shall evidence the Initial Subscriber's aggregate holding of Second Tranche Bonds in or in substantially the form set out in the Second Tranche Bond Instrument including any replacement Second Tranche Bond Certificate issued pursuant to the terms of the Second Tranche Bond Instrument.

"**Second Tranche Bond Documents**" means this Agreement, the Second Tranche Bond Instrument (including the Second Tranche Conditions), the Second Tranche Calculation Agency Agreement, each Second Tranche Bond Certificate, such other documents relating to the issuance of the Second Tranche Bonds as may be designated in writing by the Parties as being a Second Tranche Bond Document.

"**Second Tranche Bond Instrument**" means the bond instrument (including the Second Tranche Conditions) constituting the Second Tranche Bonds to be entered into by the Issuer not later than the Second Tranche Closing Date (as supplemented or amended from time to time).

"**Second Tranche Bonds**" has the meaning given to it in Recital (A).

"**Second Tranche Calculation Agency Agreement**" means the calculation agency agreement relating to the Second Tranche Bonds to be entered into not later than the Second Tranche Closing Date between the Issuer and the Calculation Agent (as supplemented or amended from time to time).

"**Second Tranche Closing**" means the completion of the issue of the Second Tranche Bonds to the Initial Subscriber.

"**Second Tranche Closing Date**" means such date as specified in the Second Tranche Request Notice (or as otherwise may be agreed in writing (including by email) between the Parties (each

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acting in its absolute discretion)), and if such day is not a Business Day, the next following Business Day.

"**Second Tranche Conditions**" means the terms and conditions of the Second Tranche Bonds which shall be set out in the Second Tranche Bond Instrument, and any reference to a particular numbered Condition shall be construed accordingly.

"**Second Tranche Register**" means the register of Second Tranche Bonds to be maintained by or on behalf of the Issuer in or substantially in the form that shall be set out in the Second Tranche Bond Instrument.

"**Second Tranche Request Notice**" means a request notice in or substantially in the form set out in Schedule 3 (*Form of Second Tranche Request Notice*).

"**Securities Act**" means the United States Securities Act of 1933, as amended.

"**Series**" has the meaning given to it in Recital (A).

"**Share Settlement Option**" has the meaning given to it in the First Tranche Conditions or the Second Tranche Conditions, as the context may require.

"**Shares**" has the meaning given to it in Recital (B).

"**Stock Exchanges**" means The Nasdaq Global Market and Euronext Brussels, and "**Stock Exchange**" means any one of them.

"**Subscription Price**" means 92.0 per cent. of the principal amount of each of the First Tranche Bonds or Second Tranche Bonds, as the case may be, to be subscribed by the Initial Subscriber upon the terms and subject to the conditions set out in this Agreement.

"**Subsidiary**" means, in relation to any Person (the "**first Person**") at any particular time, any other Person (the "**second Person**") (i) whose affairs and policies the first Person controls or has the power to control, whether by ownership of share capital, contract, the power to appoint or remove members of the governing body of the second person or otherwise or (ii) whose assets, liabilities, equity, income, expenses and cash flows are, in accordance with applicable law and the International Standards on Auditing issued by the International Federation of Accountants (as amended, supplemented or re-issued from time to time), consolidated with those of the first Person in the consolidated financial statements of such Person.

"**Term Sheet**" means the term sheet dated 5 November 2025 in respect of the Bonds of each Series between Heights Capital Management, Inc. and the Issuer.

**Transaction Press Release**" has the meaning given in Clause 9(h) (*Undertakings by the Issuer*).

"**U.S.$**" means United States Dollars, the lawful currency of the United States of America.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**1.2** **Interpretation** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Unless a contrary indication appears, any reference in this Agreement to:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the "**Initial Subscriber**" or any "**Party**" shall be construed so as to include its successors in title or assignees;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) "**assets**" includes present and future properties, revenues and rights of every description;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) a "**Bond Document**" or any other agreement or instrument is a reference to that Bond Document or other agreement or instrument as amended, novated, supplemented, extended or restated;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) a "**person**" includes any individual, firm, company, corporation, government, state or agency of a state or any association, trust, joint venture, consortium, partnership or other entity (whether or not having separate legal personality);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) a "**regulation**" includes any regulation, rule, official directive, or official guidance of any governmental, intergovernmental or supranational body, agency, department or of any regulatory, self-regulatory or other Governmental Authority; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) a provision of law is a reference to that provision as amended or re-enacted from time to time.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Time shall be of the essence in this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Headings and the table of contents are for ease of reference only and shall not affect the construction of this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) Any reference in this Agreement to a Clause or a Schedule is, unless otherwise stated, to a Clause or a Schedule hereof. The Schedules form an integral part of this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) Any reference in this Agreement to a document being in "agreed form" means that the document in question has been agreed between the Parties as of the date of this Agreement, subject to any amendments that the Parties may agree in writing prior to their entry into such documents.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) Belgian terms

Insofar as it applies to the Issuer, a reference in this Agreement to:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) "**gross negligence**" is a reference to *zware fout/faute lourde* and "**wilful misconduct**" is a reference to *opzet/intention*;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) a "**liquidator** ", "**compulsory manager** ", "**receiver** ", "**administrative receiver** ", "**administrator**" or other similar officer includes any *insolventiefunctionaris* / *praticien de l'insolvabilité*, *curator/curateur*, *vereffenaar/liquidateur*, *gerechtsmandataris/mandataire de justice*, *voorlopig bewindvoerder/administrateur provisoire*, *gerechtelijk bewindvoerder/administrateur judiciaire*, *mandataris ad hoc/mandataire ad hoc*, *vereffeningsdeskundige/praticien de la liquidation and herstructureringsdeskundige/praticien de la réorganisation,* as applicable;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) a "**reorganisation**" includes any *gerechtelijke reorganisatie/réorganisation judiciaire, procedure van minnelijk akkoord buiten gerechtelijke reorganisatie/ procédure d'accord amiable hors réorganisation judiciaire* and any *akkoord voor de kamer voor ondernemingen in moeilijkheden/accord devant la chambre des entreprises en difficulté*;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) "**security**" or "**security interest**" includes a mortgage (*hypotheek/hypothèque*), a pledge (*pand/nantissement*), a transfer by way of security (*overdracht ten titel van zekerheid/transfert à titre de garantie*), any other proprietary security interest

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(*zakelijke zekerheid/sûreté réelle*), a privilege (*voorrecht/privilège*), a reservation of title arrangement (*eigendomsvoorbehoud/réserve de propriété*), any retention right (*retentierecht/droit de rétention)* and a promise or mandate to grant a mortgage or any other proprietary security interest;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) a person being "**incorporated**" in Belgium or of which its "**jurisdiction of incorporation**" is Belgium, means that that person has its statutory seat (*statutaire zetel/siège statutaire*) in Belgium;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) a "**composition** ", "**compromise** ", "**assignment**" or "**arrangement**" includes a *gerechtelijk of buitengerechtelijk minnelijk akkoord met schuldeisers* / *accord amiable judiciaire ou extrajudiciaire avec des créanciers*, any *gerechtelijke reorganisatie/réorganisation judiciaire* or any *procedure van overdracht onder gerechtelijk gezag/ procédure de transfert sous autorité judiciaire*, as applicable;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) "**winding up** ", "**administration**" or "**dissolution**" includes any *vereffening/liquidation*, *ontbinding/dissolution*, *besloten voorbereiding van het faillissement/préparation privée d'une faillite, faillissement/faillite* and *procedure van overdracht onder gerechtelijk gezag/ procédure de transfert sous autorité judiciaire:* 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(viii) "**insolvency**" includes any *insolventieprocedure* / *procédure d'insolvabilité*, *gerechtelijke reorganisatie* / *réorganisation judiciaire*, *faillissement* / *faillite,* and any *deficitaire vereffening/liquidation déficitaire*;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ix) a "**de-merger**" or "**merger**" includes a *splitsing/scission* and a *fusie/fusion* as well as assimilated transactions (*gelijkgestelde verrichtingen/operations assimilées*) in accordance with the Belgian Code of Companies and Associations; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(x) "**share capital**" refers to the share capital of the relevant company or, in relation to any company form without share capital, the own funds of the relevant company.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**1.3** **Contracts (Rights of Third Parties) Act 1999** 

Except in respect of the rights conferred on Indemnified Persons in Clause 5 (*Indemnification of the Initial Subscriber*), a person who is not a Party to this Agreement has no right under the Contracts (Rights of Third Parties) Act 1999 to enforce any term of this Agreement, but this does not affect any right or remedy of a third party which exists or is available apart from that Act.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**2.** **Issue and Subscription of the First Tranche Bonds** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**2.1** **Undertaking to Issue the First Tranche Bonds** 

With effect from the date of this Agreement, the Issuer undertakes to the Initial Subscriber that, subject to and in accordance with the terms and conditions of this Agreement, the Issuer will on the First Tranche Closing Date:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) issue the First Tranche Bonds to the Initial Subscriber in the principal amount of €22,500,000; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) execute the First Tranche Bond Instrument, the First Tranche Calculation Agency Agreement, the First Tranche Bond Certificate in respect of the Initial Subscriber and such other documents necessary for the issuance of the First Tranche Bonds and the consummation of the transaction contemplated by this Agreement.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**2.2** **Undertaking to Subscribe for the First Tranche Bonds** 

With effect from the date of this Agreement, and subject to the satisfaction of the conditions precedent set out in Clause 3.1(a) (*Conditions Precedent to First Tranche Closing*), the Initial Subscriber undertakes to the Issuer that, subject to and in accordance with the terms and conditions of this Agreement, it will subscribe for the First Tranche Bonds in the principal amount of €22,500,000 on the First Tranche Closing Date at the Subscription Price (less any Agreed Expenses).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**2.3** **Initial Conversion Price (First Tranche Bonds)** 

Each of the Issuer and the Initial Subscriber hereby acknowledge and agree that the initial Conversion Price (as defined in the First Tranche Conditions, and rounded down (if necessary) to the nearest whole multiple of €0.0001) shall be equal to 125 per cent. of the Placing Price of the Shares being issued pursuant to the Equity Offering, as shall be publicly announced by the Issuer in connection therewith.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**3.** **Completion and Settlement** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**3.1** **Conditions Precedent to First Tranche Closing** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) The Initial Subscriber will only be obliged to subscribe for the First Tranche Bonds if:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) prior to the First Tranche Closing, the Initial Subscriber has received all of the documents listed in Schedule 1 (*First Tranche Conditions Precedent*) in form and substance reasonably satisfactory to it (in its absolute discretion), save for the documents listed in Clause 3.2(a)(ii) (*First Tranche Closing Procedure*);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) on each of the date hereof and on the First Tranche Closing Date: (A) the representations and warranties of the Issuer in this Agreement are true, accurate and correct at, and as if made on, such date, (B) the Issuer has performed all of its obligations under this Agreement to be performed on or before such date and on the First Tranche Closing Date, and (C) there has been no material breach of any of the obligations of the Issuer under this Agreement;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) on the First Tranche Closing Date, no Default is continuing or would result from the issue of the First Tranche Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) there has been no Material Adverse Change;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) in the Initial Subscriber's opinion (acting in good faith), since the date of this Agreement there has been no adverse change in the financial markets in the United States, the Cayman Islands, Belgium, the European Economic Area or the international financial markets, any outbreak of hostilities or escalation thereof, any act of terrorism or war or any declaration of emergency or martial law or other calamity or crisis (including without limitation, a material escalation in any pandemic on or after the date of this Agreement) nor any change or development involving a prospective change in national or international political, financial or economic conditions, currency exchange rates or exchange controls, whether or not foreseeable at the date of this Agreement, which would reasonably be considered material in the context of the issue of the First Tranche Bonds and the purchase thereof by the Initial Subscriber;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) on or prior to the First Tranche Closing, the Initial Subscriber's Solicitors have received the documents listed in Clause 3.2(a)(ii) (*First Tranche Closing Procedure*) to be held in escrow pending the First Tranche Closing;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) on or prior to the First Tranche Closing Date, and save for any Shares to be issued in connection with the Equity Offering or any Excluded Instrument, there are no issuances of and no grants of rights in respect of, or sales or subscriptions of, nor has the Issuer entered into any agreement, contract, instrument or other document in respect of, any of the following: (A) the Shares; (B) ordinary shares in any other series in the ordinary shares of the Issuer; or (C) Securities (as defined in the First Tranche Conditions) which by their terms carry (directly or indirectly) rights of conversion into, or exchange or subscription for, or the right to otherwise acquire, any Shares or any other shares in the capital of the Issuer;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(viii) the First Tranche Closing Date occurs on or prior to the date falling 22 calendar days after the date of this Agreement (or such other date as may be agreed in writing (including by email) the Parties (each acting in its absolute discretion)), and if such day is not a Business Day, the next following Business Day; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ix) on or prior to the First Tranche Closing Date:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) the Equity Offering is announced, priced and consummated with the gross proceeds being no less than €20,000,000; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) the Shares being issued pursuant to the Equity Offering are validly admitted to trading on a Stock Exchange.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) The Initial Subscriber shall notify the Issuer promptly upon receipt by or on behalf of the Initial Subscriber of all of the documents and other evidence listed in Schedule 1 (*First Tranche Conditions Precedent*) in form and substance reasonably satisfactory to it.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) The Initial Subscriber may, in its absolute discretion and upon such terms as it thinks fit, waive compliance with the whole or any part of this Clause 3.1.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) If, on the First Tranche Closing Date, any of the conditions precedent provided in Clause 3.1 have not been satisfied, nor waived as provided in Clause 3.1(c) above, then the Initial Subscriber shall, at its election, be relieved of all its obligations under Clause 2.2 (*Undertaking to Subscribe for the First Tranche*) to subscribe for the First Tranche Bonds under this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) An election by the Initial Subscriber under Clause 3.1(d) above shall not operate as a waiver of any rights the Initial Subscriber may have by reason of such failure to satisfy or such non-fulfilment.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**3.2** **First Tranche Closing Procedure** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Following the notification to the Issuer referred to in Clause 3.1(b) (*Conditions Precedent to First Tranche Closing*), and by no later than the First Tranche Closing Date:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the Issuer shall make (or shall procure the making of) the appropriate entries in the First Tranche Register showing the Initial Subscriber as the registered owner of €22,500,000 in principal amount of First Tranche Bonds; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the Issuer shall issue and deliver to the Initial Subscriber's Solicitors:

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) the initial First Tranche Bond Certificate dated the First Tranche Closing Date in respect of the First Tranche Bonds; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) a certified excerpt of the First Tranche Register reflecting the entries referred to in Clause 3.2(a)(i) above,

such documents to be held in escrow to the Issuer's order until such time as they are deemed to be released pursuant to Clause 3.2(d) below.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) At the First Tranche Closing, and following confirmation of receipt from the Initial Subscriber's Solicitors of the documents specified in Clause 3.2(a)(ii) above, the Initial Subscriber shall pay or procure the payment of its subscription monies (net of any Agreed Expenses) in immediately available funds to the following account:

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| | |
|:---|:---|
| Account Holder: | [\*\*\*] |
| Account number: | [\*\*\*] |
| Bank: | [\*\*\*] |
| Swift/Bic | [\*\*\*] |

---

or such other account of the Issuer as the Issuer designates to the Initial Subscriber in writing at least five Business Days prior to the First Tranche Closing Date.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) The Initial Subscriber shall promptly notify the Issuer that it has effected the payment specified in Clause 3.2(b) above and provide evidence or a receipt of such payment transfer.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) Upon receipt of the net subscription monies specified in Clause 3.2(b) above, the documents referred to in Clause 3.2(a)(ii) above shall be deemed to be automatically released by the Issuer to or to the order of the Initial Subscriber.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) The Issuer shall promptly on the First Tranche Closing Date furnish a written confirmation to the Initial Subscriber of its receipt of the relevant subscription monies.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**4.** **Issue and Subscription of the Second Tranche Bonds** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**4.1** **Second Tranche Request Notice** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) During the period commencing from (and including) the date falling seven months following the First Tranche Closing Date to (but excluding) the date falling one month thereafter, the Issuer may (on one occasion only) request the subscription by the Initial Subscriber of Second Tranche Bonds in a principal amount of €22,500,000 (unless a lesser amount is agreed in writing (including by email) between the Parties) by delivering a Second Tranche Request Notice to the Initial Subscriber (which may be delivered by email and in accordance with Clause 10 (*Notices*)) not later than five Business Days prior to the Second Tranche Closing Date (or such date as may be agreed in writing (including by email) between the Parties). Any Second Tranche Request Notice shall be irrevocable once delivered.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) The Issuer acknowledges that the Second Tranche Request Notice may contain Restricted Information. The Issuer shall (in consultation with the Initial Subscriber) do whatever is necessary to ensure that any such Restricted Information is publicly disclosed to the market in accordance with applicable laws, regulations or rules (including, for the avoidance of doubt, by way of announcement through a Regulatory Information Service and Form 6-K (or similar)) or as otherwise may be effective so as to ensure that, on the same date of

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delivery of a Second Tranche Request Notice in accordance with paragraph (a) above, the Initial Subscriber is no longer in possession of Restricted Information and is no longer restricted from trading in any securities or instruments of the Issuer or any of its Subsidiaries or any other person by reason of the receipt of that Restricted Information.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**4.2** **Undertaking to Issue the Second Tranche Bonds** 

Subject to and in accordance with the terms and conditions of this Agreement, the Issuer will on the Second Tranche Closing Date:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) issue the Second Tranche Bonds to the Initial Subscriber in the principal amount of €22,500,000 (subject to Clause 4.1(a) (*Second Tranche Request Notice*)); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) execute the Second Tranche Bond Instrument, the Second Tranche Calculation Agency Agreement, the Second Tranche Bond Certificate in respect of the Initial Subscriber and such other documents necessary for the issuance of the Second Tranche Bonds and the consummation of the transaction contemplated by this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**4.3** **Undertaking to Subscribe for the Second Tranche Bonds** 

Subject to the satisfaction of the conditions precedent set out in Clause 4.4 (*Terms of the Second Tranche Bonds*) and Clause 4.5 (*Conditions Precedent to Second Tranche Closing*), the Initial Subscriber undertakes to the Issuer that, subject to and in accordance with the terms and conditions of this Agreement, it will subscribe for the Second Tranche Bonds in the principal amount of €22,500,000 (subject to Clause 4.1(a) (*Second Tranche Request Notice*)) on the Second Tranche Closing Date at the Subscription Price (less any costs and expenses (including legal expenses) properly incurred by the Initial Subscriber in connection therewith).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**4.4** **Terms of the Second Tranche Bonds** 

Each of the Issuer and the Initial Subscriber hereby agree that the terms of the Second Tranche Bonds and the Second Tranche Bond Documents shall be substantially in the form of the terms of the First Tranche Bonds and the First Tranche Bond Documents, except that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the maturity date of the Second Tranche Bonds shall be the date falling on the third anniversary of the Second Tranche Closing Date;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the initial conversion price of the Second Tranche Bonds shall be equal to 125 per cent. of the EUR price per Share (rounded down (if necessary) to the nearest whole multiple of €0.0001) that is equal to the lowest of the five Volume Weighted Average Prices (as defined in the First Tranche Conditions) of a Share on Euronext Brussels on each of the five consecutive dealing days (as defined in the First Tranche Conditions) ending on (but excluding) the Second Tranche Closing Date;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) the first payment date for principal and interest under the Second Tranche Bond shall occur on the date falling on:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) if the next Scheduled Amortisation Payment Date and Interest Payment Date shall occur more than one calendar month after the Second Tranche Closing Date, that next upcoming Scheduled Amortisation Payment Date and Interest Payment Date (each as defined in the First Tranche Conditions) under the First Tranche Bonds; or

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) if the next Scheduled Amortisation Payment Date and Interest Payment Date shall occur less than or on the date falling one calendar month after the Second Tranche Closing Date, the subsequent Scheduled Amortisation Payment Date and Interest Payment Date after the occurrence of such foregoing payment date; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) such other terms as may be mutually agreed between the Parties in writing.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**4.5** **Conditions Precedent to Second Tranche Closing** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) The Initial Subscriber will only be obliged to subscribe for the Second Tranche Bonds if:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) prior to the Second Tranche Closing, the Initial Subscriber has received all of the documents listed in Schedule 2 (*Second Tranche Conditions Precedent*) in form and substance reasonably satisfactory to it (in its absolute discretion), save for the documents listed in Clause 3.2(a)(ii) (*First Tranche Closing Procedure*) (which shall be construed in accordance with Clause 4.6 (*Second Tranche Closing Procedure*));

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) on the Second Tranche Closing Date: (A) the representations and warranties of the Issuer in this Agreement are true, accurate and correct at, and as if made on, such date, (B) the Issuer has in all material respects performed all of its respective obligations under this Agreement to be performed on or before such date and on the Second Tranche Closing Date, and (C) there has been no material breach of any of the obligations of the Issuer under this Agreement;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) on the Second Tranche Closing Date, no Default is continuing or would result from the issue of the Second Tranche Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) there has been no Material Adverse Change;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) in the Initial Subscriber's opinion (acting in good faith), since the date of this Agreement there has been no adverse change in the financial markets in the United States, the Cayman Islands, Belgium, the European Economic Area or the international financial markets, any outbreak of hostilities or escalation thereof, any act of terrorism or war or any declaration of emergency or martial law or other calamity or crisis (including without limitation, a material escalation in any pandemic on or after the date of this Agreement) nor any change or development involving a prospective change in national or international political, financial or economic conditions, currency exchange rates or exchange controls, whether or not foreseeable at the date of this Agreement, which would reasonably be considered material in the context of the issue of the Second Tranche Bonds and the purchase thereof by the Initial Subscriber;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) between the date of the Second Tranche Request Notice and the Second Tranche Closing (inclusive), the Initial Subscriber's Solicitors have received the documents listed in Clause 3.2(a)(ii) (*First Tranche Closing Procedure*) (which shall be construed in accordance with Clause 4.6 (*Second Tranche Closing Procedure*)) to be held in escrow pending Second Tranche Closing;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) between the date of the Second Tranche Request Notice and the Second Tranche Closing Date (inclusive), and save for any Shares to be issued in connection with any Excluded Instrument or the First Tranche Bonds, there are no issuances of and no grants of rights in respect of, or sales or subscriptions of, nor has the Issuer entered into any agreement, contract, instrument or other document in respect of,

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any of the following: (A) the Shares; (B) ordinary shares in any other series in the ordinary shares of the Issuer; or (C) Securities (as defined in the Second Tranche Conditions) which by their terms carry (directly or indirectly) rights of conversion into, or exchange or subscription for, or the right to otherwise acquire, any Shares or any other shares in the capital of the Issuer;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(viii) the Second Tranche Closing Date occurs on or prior to the date falling 22 calendar days after the date of the Second Tranche Request Notice (or such other date as may be agreed in writing (including by email) the Parties (each acting in its absolute discretion)), and if such day is not a Business Day, the next following Business Day;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ix) the arithmetic mean (rounded to the nearest whole multiple of U.S.$1.00 (with U.S.$0.50 being rounded upwards)) of the Daily Traded Values (determined in accordance with limb (i) of the definition thereof in the First Tranche Conditions, but for this purpose (A) disregarding the words "(for the purposes of determining any Share Average DTV)" and (B) assuming the reference to "EUR" to be a reference to "U.S.$") of the Shares on each Qualifying Stock Exchange Day comprised in the period of 60 consecutive Qualifying Stock Exchange Days (as defined in the First Tranche Conditions) ending on the Qualifying Stock Exchange Day immediately preceding the date of the Second Tranche Request Notice is greater than U.S.$1,000,000 (or its equivalent in any other currency), all as determined by the Calculation Agent; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(x) the Issuer has a Last Market Capitalisation and an Average Market Capitalisation that are each greater than €240,000,000, as determined by the Calculation Agent.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) The Initial Subscriber shall notify the Issuer promptly upon receipt by or on behalf of the Initial Subscriber of all of the documents and other evidence listed in 2 (*Second Tranche Conditions Precedent*) in form and substance satisfactory to it.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) The Initial Subscriber may, in its absolute discretion and upon such terms as it thinks fit, waive compliance with the whole or any part of this Clause 4.5.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) If, on the Second Tranche Closing Date, any of the conditions precedent provided in Clause 4.5(a) above have not been satisfied, nor waived as provided in Clause 4.5(c) above, then the Initial Subscriber shall, at its election, be relieved of all its obligations under Clause 4.3 (*Undertaking to Subscribe for the Second Tranche Bonds*) to subscribe for the Second Tranche Bonds under this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) An election by the Initial Subscriber under Clause 4.5(d) above shall not operate as a waiver of any rights the Initial Subscriber may have by reason of such failure to satisfy or such non-fulfilment.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**4.6** **Second Tranche Closing Procedure** 

The closing procedure set out in Clause 3.2 (*First Tranche Closing Procedure*) shall apply to the Second Tranche Bonds Closing, except that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) any reference to the First Tranche Bonds shall be construed to refer to the Second Tranche Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) any reference to the First Tranche Closing Date or First Tranche Closing shall be construed to refer to the Second Tranche Closing Date or Second Tranche Closing, respectively;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) any reference to the First Tranche Register or the First Tranche Bond Certificate shall be construed to refer to the Second Tranche Register or the Second Tranche Bond Certificate, respectively;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) Clause 3.2(a)(i) (*First Tranche Closing Procedure*) shall be deemed to be modified to read:

"the Issuer shall make (or shall procure the making of) the appropriate entries in the Second Tranche Register showing the Initial Subscriber as the registered owner of €22,500,000 in principal amount of Second Tranche Bonds"; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) the reference to "(net of any Agreed Expenses)" in Clause 3.2(b) (*First Tranche Closing Procedure*) shall be modified to read "(less any costs and expenses (including legal expenses) properly incurred by the Initial Subscriber in connection with the issue of the Second Tranche Bonds)".

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**5.** **Indemnification of the Initial Subscriber** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**5.1** **Indemnity** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) The Issuer agrees to indemnify and hold harmless the Initial Subscriber and each of its affiliates and all their respective officers, directors, general partners, employees, Heights Capital Management, Inc., Heights Capital Ireland, LLC, their respective shareholders, affiliates and representatives and each of their respective successors (but, for the avoidance of doubt, not including any permitted transferee or assignee of the Initial Subscriber) (each, an "**Indemnified Person**") from and against any and all actions, suits, investigation, inquiry, claims, losses, damages, liabilities, proceedings and documented related and properly incurred out-of-pocket fees and expenses of any kind or nature (a "**Loss**") (subject to the limitations set forth in this Clause 5) which may be incurred by any such Indemnified Person as a result of or arising out of or in connection with or based on:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) *Misrepresentation*: any breach or alleged breach of the representations and warranties contained in, or made or deemed to be made by the Issuer under, this Agreement by reference to the facts and circumstances then subsisting; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) *Breach*: any breach or alleged breach by the Issuer of any of its obligations in any Bond Document or the Bonds of any Series (including, without limitation, the failure by the Issuer to issue the First Tranche Bonds on the First Tranche Closing Date or the Second Tranche Bonds on the Second Tranche Closing Date, as the case may be); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) *Announcements*: any untrue statement contained in any announcement or press release published following the date hereof by or on behalf of the Issuer or any of its Subsidiaries or their respective affiliates in connection with the First Tranche Bonds or the Second Tranche Bonds, or any omission or alleged omission of a material fact required to be stated therein or necessary to make the statements therein, in light of the circumstances in which they are made, not misleading.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) The Issuer shall pay to the relevant Indemnified Person within 10 Business Days of written demand therefor an amount equal to such Loss; *provided, however*, *that* no Indemnified Person will be entitled to indemnity hereunder in respect of any Loss to the extent that it is finally judicially determined by a court of competent jurisdiction that such Loss resulted from the negligence, bad faith or wilful misconduct of such Indemnified Person or its

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affiliates, officers, directors, partners, trustees, employees, shareholders, agents or controlling persons (all such persons "**Related Parties**").

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) This Agreement shall not cause to the Initial Subscriber to have any duty or obligation, whether as fiduciary or trustee for any Indemnified Person or Related Party or otherwise, to recover any such payment or to account to any other person for any amounts paid to it under this Clause 5.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**5.2** **Conduct of Claims** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) In case any action or claim shall be brought against any Indemnified Person in respect of which recovery may be sought from the Issuer under this Clause 5, the relevant Indemnified Person shall promptly notify the Issuer in writing of such fact, but failure to do so will not relieve the Issuer from any liability under this Agreement and in any event shall not relieve it from any liability which it may have otherwise than on account of the indemnities contained in this Agreement except, in the case of an unreasonable delay to notify the Issuer by such Indemnified Person, to the extent that such delay actually and materially prejudices the Issuer.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Each Indemnified Person shall thereafter, subject to any requirement imposed by an insurer of the Indemnified Person and to the extent permitted by applicable law or regulation:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) at reasonable intervals keep the Issuer informed of the progress of the claim or action;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) provide the Issuer with copies of such documentation relating to the claim or action as the Indemnified Person may reasonably request; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) maintain reasonable consultation with the Issuer regarding decisions concerning the claim or action,

subject in each case to the Indemnified Person being indemnified and secured to its reasonable satisfaction against all Losses incurred by it in consequence of its compliance with this Clause 5, and provided that nothing in this Clause 5 shall:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) require any Indemnified Person to provide the Issuer with a copy of any part of any document which it, in good faith, considers to be held by it subject to a duty of confidentiality or to be privileged whether in the context of any litigation connected with the claim or otherwise; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) require an Indemnified Person to do, or refrain from doing, anything which would, or which the Issuer considers might, either prejudice any insurance cover to which it or any other Indemnified Person may from time to time be entitled, or from which it or any of them may benefit or which may prejudice the reputation or standing of such Indemnified Person or of any other Indemnified Person.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) The Issuer may participate at its own expense in the defence of any such action; *provided, however, that* legal advisers to the Issuer shall not (except with the consent of the relevant Indemnified Person (such consent not to be unreasonably withheld, conditioned or delayed)) also be legal advisers to the Indemnified Person.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) The Issuer shall not, without the prior written consent of the relevant Indemnified Person (such consent not to be unreasonably withheld, conditioned or delayed), settle or

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compromise or consent to the entry of any judgment with respect to any litigation, or any investigation or proceeding by any governmental agency or body, commenced or threatened, or any claim whatsoever in respect of which indemnification could be sought under this Clause 5 (whether or not the Indemnified Person(s) are actual or potential parties thereto), unless such settlement, compromise or consent:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) includes an unconditional release of each Indemnified Person from all liability arising out of such litigation, investigation, proceeding or claim; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) does not include a statement as to or an admission of fault, culpability or a failure to act by or on behalf of any Indemnified Person.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**5.3** **Currency Indemnity** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) If any sum due from the Issuer under this Agreement (a "**Sum** "), or any order, judgment or award given or made in relation to a Sum, has to be converted from the currency (the "**First Currency**") in which that Sum is payable into another currency (the "**Second Currency**") for the purpose of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) making or filing a claim or proof against the Issuer; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) obtaining or enforcing an order, judgment or award in relation to any litigation or arbitration proceedings,

the Issuer shall as an independent obligation, within five Business Days of demand, indemnify the Initial Subscriber to whom that Sum is due against any cost, loss or liability arising out of or as a result of the conversion, including any discrepancy between (A) the rate of exchange used to convert that Sum from the First Currency into the Second Currency and (B) the rate or rates of exchange available to that person at the time of its receipt of that Sum.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) The Issuer waives any right it may have in any jurisdiction to pay any amount under this Agreement in a currency or currency unit other than that in which it is expressed to be payable.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**5.4** **Other Indemnities** 

The Issuer shall, within five Business Days of demand, indemnify the Initial Subscriber against any cost, loss or liability properly incurred by the Initial Subscriber (acting reasonably) as a result of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) investigating any event which it reasonably believes is a breach of the terms of this Agreement; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) acting or relying on any notice, request or instruction which it reasonably believes to be genuine, correct and appropriately authorised.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**6.** **Costs and Expenses** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**6.1** **Transaction Expenses** 

With effect from the date of this Agreement:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the Issuer shall be responsible for its own expenses and the fees and expenses of all third parties (including the Calculation Agent) appointed under or in connection with the Bonds

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of each Series, in connection with the preparation and execution of the Bond Documents and the issue and performance of the Bonds of each Series;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the Issuer shall be responsible for any costs and expenses (including legal fees) properly incurred by the Initial Subscriber in connection with the preparation and execution of the First Tranche Bond Documents and the consummation of the issuance of the First Tranche Bonds, *provided that* the amount payable by the Issuer under this paragraph shall not exceed an amount equal to [\*\*\*] (or its equivalent in any other currency) (it being agreed that such limitation is without prejudice to any value added or similar tax payable thereon, which shall be borne by the Issuer). The Initial Subscriber shall be responsible for any costs and expenses so incurred by it in excess of such limitation;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) the Issuer shall be responsible for any reasonable costs and expenses (including legal fees) properly incurred by the Initial Subscriber in connection with the preparation, negotiation or execution of any documents or instruments with the European Investment Bank in the context of the transactions envisaged by this Agreement; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) the Issuer shall be responsible for any reasonable costs and expenses (including legal fees) properly incurred by the Initial Subscriber in connection with the preparation and execution of the Second Tranche Bond Documents and the consummation of the issuance of the Second Tranche Bonds.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**6.2** **Amendment Costs** 

If the Issuer requests an amendment, waiver or consent in respect of any of the Bond Documents and such requests for amendments, waivers or consents require legal fees to be incurred, the Issuer shall, within five Business Days of demand, reimburse the Initial Subscriber for the reasonable amount of such legal costs and expenses properly incurred by it in responding to, evaluating, negotiating or complying with that request or requirement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**6.3** **Ongoing Costs** 

The Issuer shall, within five Business Days of demand, reimburse the Initial Subscriber for any reasonable costs and expenses incurred by the Initial Subscriber from time to time in connection with (a) its compliance with any terms of the Bond Documents applicable to it, and (b) its compliance with any applicable reporting obligations that it becomes subject to in connection with the execution or performance of any of the Bond Documents, including it becoming the beneficial owner of (and any subsequent disposal of) any Shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**6.4** **Enforcement Costs** 

The Issuer shall, within five Business Days of demand, pay to the Initial Subscriber the amount of all reasonable costs and expenses (including legal fees) incurred by the Initial Subscriber in connection with the enforcement of, or the preservation of any rights under, the Bonds of any Series and the Bond Documents.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**7.** **Representations and Warranties of the Issuer** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**7.1** **Representations and Warranties** 

The Issuer makes the representations and warranties set out below in this Clause 7.1 to the Initial Subscriber in respect of the First Tranche Bonds on the date of this Agreement, on the First Tranche Closing Date and on each intervening day:

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) That:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) no Public Statement (save as modified, supplemented or superseded by any other Public Statement) contained an untrue statement of a material fact or omitted to state a material fact necessary to make the statements therein, in light of the circumstances under which they were made, not misleading;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) all expressions of opinion, forecasts or estimates of the Issuer contained in any such Public Statements were made in good faith on reasonable grounds after due and careful consideration and all such forecasts, estimates and expressions of opinion, intention or expectation remain truly and honestly held;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) other than in respect of the matters which are the subject of this Agreement and the Equity Offering, none of the Issuer nor any of its directors or officers are, after due and careful consideration, aware of any non-public fact, circumstance or information that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) constitutes Restricted Information with respect to the Bonds of either Series, the Shares, the Issuer or any of its Subsidiaries, or would reasonably be expected to become, required or obliged to publish or otherwise make available to the public pursuant to applicable laws and regulations (including under applicable listing requirements), whether to correct a misleading impression or otherwise to avoid behaviour which would constitute market abuse (in contravention of Regulation 596/2014/EU or any other applicable insider dealing or market abuse law) which has not been published;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) relates to any actual, ongoing or pending claim, dispute, investigation or proceeding initiated by or otherwise involving Inspire Medical or its Subsidiaries or its affiliates and, to the best of the Issuer's knowledge, no claim, dispute, investigation or proceedings are threatened or contemplated by Inspire Medical against the Issuer, its Subsidiaries or its affiliates; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(C) is currently, or would reasonably be expected to become, the subject of any application or request to delay disclosure or otherwise extend any deadline for mandatory disclosure under applicable law; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(D) if made public, would be likely to have a significant effect upon the market price of the Shares, and in respect of which the Issuer has delayed disclosure in compliance with applicable law; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) the Issuer is in compliance with the rules for companies published by each Stock Exchange (including, but not limited to, continuing disclosure obligations) and all other rules of other stock exchanges which are applicable to it;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) the Issuer does not have to publish or update a prospectus or a similar disclosure document which requires approval by a regulatory authority, neither in connection with the issue of the First Tranche Bonds, the issuance and delivery of Shares upon conversion of the First Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds, in each case under or pursuant to the Regulation (EU) 2017/1129 of the European Parliament and of the Council of 14

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June 2017, as amended, any other applicable laws or regulations, or any rules and regulations of, or applicable to, each Stock Exchange;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) neither the Issuer nor any of its Subsidiaries nor any of their respective affiliates have entered into any commitment, term sheet, memorandum of understanding, agreement or other contract (whether binding or non-binding) in connection with any mergers, de-mergers, acquisitions or disposals of, or partnerships, joint ventures or similar arrangements in respect of, any businesses, properties and/or assets of the Issuer or any of its Subsidiaries, nor are they currently involved in negotiations or discussions that would contemplate their entry into any such transaction(s); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) other than as disclosed in the Public Statements, neither the Issuer nor any of its Subsidiaries has entered into any contract or commitment or incurred any liability (including any contingent liability) which is (1) outside the ordinary course of business or (2) of an unusual or onerous nature;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the annual audited consolidated financial statements of the Issuer and its Subsidiaries for each of the two most recent financial years ended 31 December for which such audited consolidated financial statements have been published; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the interim condensed consolidated financial statements of the Issuer and its Subsidiaries as of and for the end of its most recent interim financial period in respect of which such financial statements are published,

in each case, were prepared in accordance with the requirements of law and with IFRS accounting principles generally accepted in Belgium consistently applied and that they give a true and fair view of its assets, liabilities, financial position and results of the Issuer and its Subsidiaries (on a consolidated basis) as at the dates indicated;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) that since the date falling on the end of its most recent financial year in respect of which audited consolidated financial statements are published:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the Issuer and its Subsidiaries do not have any contingent obligations (including any contingent payment obligations in respect of indebtedness of third parties), liabilities for taxes or other outstanding obligations or liabilities, fixed or contingent, which are material in the aggregate;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) there has been no change nor any development or event involving a prospective change which is materially adverse to the condition (financial or otherwise), business or general affairs, results of operations, properties or profitability of the Issuer and its Subsidiaries (taken as a whole) or the ability of the Issuer to perform its obligations under the First Tranche Bond Documents and the First Tranche Bonds; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) none of the Issuer or any of its Subsidiaries has any material off-balance sheet financing, investments or liabilities to be disclosed in accordance with applicable laws or financial reporting rules;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) that the Issuer and each of its Subsidiaries:

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) is not in violation of its certification of incorporation, articles of association or bylaws (or similar organisational or constitutional documents);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) is not in breach of any terms of, or in default under, any indenture, mortgage, deed of trust, loan or credit agreement, lease, licence, order or other agreement or instrument to which it is a party or by which it or its property is bound and no event has occurred which with the giving of notice or lapse of time or other condition would constitute a default under any such indenture, mortgage, deed of trust, loan or credit agreement, lease, licence, order or other agreement or instrument;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) is not engaged (whether as defendant or otherwise) in, nor has the Issuer knowledge of the existence of, or any written threat of, any legal, regulatory, arbitration, administrative, governmental or other proceedings or investigations with respect to the Issuer or any of its Subsidiaries; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) has not taken any action nor, to the best of their knowledge or belief having made all reasonable enquiries, have any steps been taken or legal proceedings commenced for the winding up or dissolution of the Issuer or any of its Subsidiaries;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the dematerialized Shares issued by the Issuer as at the date hereof are and traded on each Stock Exchange in compliance with all applicable listing rules and the Issuer is in compliance with all applicable listing rules relating to the Shares, and it has made all applicable regulatory filings in respect of the listing and admission to trading of the Shares with each Stock Exchange;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) there are no outstanding securities convertible into or exchangeable for, or subscription rights, warrants, rights or options to purchase from the Issuer or any of its Subsidiaries, or obligations, commitments or intentions of the Issuer or any of its Subsidiaries to create the same or to issue, sell or otherwise dispose of, any shares of the Issuer or of any of its Subsidiaries, other than pursuant to the Excluded Instruments and the First Tranche Bonds; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) no authorisation, approval or consent of any governmental authority or agency of Belgium, the United States or of any other jurisdiction is required to effect dividend payments or distributions in respect of any Shares to be delivered upon conversion of the First Tranche Bonds or pursuant to any Share Settlement Option under the First Tranche Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) that each of the Issuer and each of its Subsidiaries has been duly incorporated and is validly existing under the laws of its jurisdiction of incorporation and is not in liquidation, receivership, judicial reorganisation or bankruptcy and has full power and authority to own, lease and operate its properties and conduct its business, (in the case of the Issuer only) to execute and perform its obligations under the First Tranche Bond Documents and the First Tranche Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) that the issue of the First Tranche Bonds, the issuance and delivery of Shares upon conversion of the First Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds and the execution and delivery of the First Tranche Bond Documents have been duly authorised by the Issuer and, in the case of the First Tranche Bonds, upon due execution, issue and delivery in accordance with the First Tranche Bond

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Instrument will constitute, and, in the case of the First Tranche Bond Documents, upon due execution and delivery (as applicable), constitute, legal, valid and binding obligations of the Issuer enforceable in accordance with their respective terms, subject to the laws of bankruptcy and other laws affecting the rights of creditors generally;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) that the consummation of the Equity Offering, the execution and delivery of the First Tranche Bond Documents, the issuance and delivery of Shares upon conversion of the First Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds, the issue and distribution of the First Tranche Bonds in accordance with the First Tranche Bond Documents and the performance of the terms of the First Tranche Bonds and the First Tranche Bond Documents:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) is not in breach of or will not conflict with, or result in a breach of or constitute a default under, any of the terms or provisions of, or constitute a default under, any indenture, mortgage, deed of trust, loan or credit agreement, lease, licence, order or other agreement or instrument to which the Issuer or any of its Subsidiaries is a party or by which any of them or any of their respective properties or assets are bound;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) will not infringe any law, regulation, order, binding rule, or decree of any government, governmental or regulatory body or court, domestic or foreign, having jurisdiction over the Issuer or any of its Subsidiaries or any of their respective properties or assets;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) infringe the rules of any stock exchange on which securities of the Issuer (including the Stock Exchanges) are listed or contravene Belgian public policy; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) are not contrary to the provisions of the constitutional documents of the Issuer or any of its Subsidiaries or corporate law generally applicable to companies in their country of incorporation;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) all of the Shares as at the date hereof have been duly and validly authorised and issued and are fully paid;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) none of the outstanding share capital of the Issuer has been issued in violation of any pre-emptive rights or similar rights of any shareholder;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) the board of directors of the Issuer has or will have authority to issue and allot, free from pre-emption rights, Shares to enable the conversion rights under the First Tranche Bonds to be satisfied in full pursuant to the First Tranche Conditions (including in respect of the exercise of any Share Settlement Option), and all other rights of subscription and conversion into Shares to be satisfied in full in accordance with the First Tranche Conditions;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) the Shares to be issued and/or delivered upon conversion of the First Tranche Bonds or pursuant to the exercise of a Share Settlement Option under the First Tranche Bonds will be fully paid and will not be subject to calls for further funds and will be free and clear of all liens, charges, pledges, encumbrances, security interest, claims and other third-party rights;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) the Shares to be issued and/or delivered upon conversion of the First Tranche Bonds or pursuant to the exercise of a Share Settlement Option under the First Tranche Bonds will rank *pari passu* with the then outstanding Shares;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) the subscription of the First Tranche Bonds and all Shares to be issued and/or delivered upon conversion of the First Tranche Bonds or pursuant to the exercise of a Share Settlement Option under the First Tranche Bonds will not be subject to any pre-emptive, first-refusal or similar rights arising under applicable law or under the articles of association (or other constitutional documents) of the Issuer in force from time to time, and is not subject to other similar rights arising under applicable law or under such articles of association (or other constitutional document) of the Issuer; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) except as provided by general provisions of Belgian law, there are no restrictions or limitations concerning the voting rights or transfers of the Shares, any declaration or payment of dividends or any other contributions statutorily due to the holders of the Shares whether pursuant to any agreement or otherwise;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(j) all written information provided by or on behalf of the Issuer to the Initial Subscriber under or in connection with the First Tranche Bond Documents was true, complete and accurate in all material respects at the date it was provided or as at the date (if any) at which it is stated to be given and did not omit any information which, if disclosed, might make that information untrue or misleading in any material respect;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(k) that no event has occurred which would constitute (if the First Tranche Bond Documents had been duly executed and the First Tranche Bonds were issued and outstanding) an Event of Default, a Potential Event of Default or a Relevant Event (each as defined in the First Tranche Conditions);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(l) that all required consents, approvals, authorisations, orders, filings, registrations or qualifications of or with any court or Governmental Authority or agency of Belgium, the United States or of any other jurisdiction that is applicable to the Issuer and its Subsidiaries have been given, fulfilled or done for or in connection with the execution, issue and distribution of the First Tranche Bonds and compliance by the Issuer with the terms of the First Tranche Bonds, the issuance and delivery of Shares upon conversion of the First Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds, or the execution and delivery of, and compliance with the terms of, the First Tranche Bond Documents;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(m) that the Issuer and its Subsidiaries together own, possess or can acquire on reasonable terms, adequate Intellectual Property Rights necessary to conduct the business now operated by them, or presently employed by them and, to the best of the Issuer's knowledge, have not received any notice of infringement of or conflict with asserted rights of others with respect to any Intellectual Property Rights;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(n) that there are no circumstances, facts or proceedings of which the Issuer or any of its Subsidiaries is aware which indicate that any licences, grants or legal or regulatory approvals, registrations or the like relating to any of their respective actual or prospective Intellectual Property Rights or work products are at a risk of being, have been or will be rejected or otherwise not be granted by the applicable licensing, regulatory, legal or other bodies;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(o) that the Issuer's and its Subsidiaries' information technology assets and equipment, computers, systems, networks, hardware, software, websites, applications, and databases (collectively, the "**IT Systems**") operate and perform in all material respects as required in connection with the operation of their respective businesses as currently conducted and, to the best knowledge of the Issuer, free and clear of all bugs, errors, defects, Trojan horses, time bombs, malware and other corruptants, other than those not reasonably expected to have a Material Adverse Effect. The Issuer and their respective Subsidiaries maintain commercially reasonable controls, policies, procedures, and safeguards to maintain and protect their material confidential information and the integrity, continuous operation, redundancy and security of all IT Systems and all personal, personally identifiable, sensitive, confidential or regulated data (the "**Personal Data**") processed and stored thereon and, to the best knowledge of the Issuer, there have been no breaches, incidents, violations, outages, compromises or unauthorised uses of or accesses to same, except for those that have been remedied without material cost or liability or the duty to notify any other person, nor any incidents under internal review or investigations relating to the same, other than those not reasonably expected to have a Material Adverse Effect. The Issuer and their respective Subsidiaries are presently in compliance in all material respects with all applicable laws and statutes and all applicable judgments, orders, rules and regulations of any court or arbitrator or governmental or regulatory authority, internal policies and contractual obligations relating to the privacy and security of IT Systems and Personal Data and to the protection of such IT Systems and Personal Data from unauthorised use, access, misappropriation or modification;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(p) that all real estate currently owned, occupied or leased by the Issuer or any of its Subsidiaries is lawfully owned, occupied or leased by it and any real property held under lease by the Issuer or any of its Subsidiaries is held by them under valid, existing and enforceable leases and does not interfere with the use made or proposed to be made of such property and buildings by the Issuer or any of its Subsidiaries;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(q) all statutory, municipal and other licences, franchises, consents, permits, approvals, orders, authorities and other concessions necessary and material for the carrying on of the businesses and operations of the Issuer and each of its Subsidiaries as now carried on and as previously carried on have been obtained (collectively, "**Licences**") and are (or were at the relevant time) valid and subsisting;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(r) all conditions applicable to any such Licence have been and are complied with and the Issuer and its Subsidiaries are not in breach of any such Licence, except where any such breach could reasonably be expected to result in the Issuer incurring Losses in an amount that is less than U.S.$250,000;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(s) there are no circumstances or proceedings of which the Issuer is aware which indicate that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) any such Licence may be; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) if determined adversely to the Issuer or any of its Subsidiaries, may cause any such Licence to be,

revoked, rescinded, modified, avoided or repudiated or not renewed, in whole or in part, in the ordinary course of events;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(t) that:

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) neither the Issuer nor any of its Subsidiaries is in violation of any applicable statute, law, rule, regulation, ordinance or rule of civil or common law or any judicial or administrative interpretation thereof, including any judicial or administrative order, consent, decree or judgment, relating to pollution or protection of human health, the environment (including, without limitation, ambient air, surface water, groundwater, land surface or subsurface strata) or wildlife, including, without limitation, laws and regulations relating to the release or threatened release of chemicals, pollutants, contaminants, wastes, toxic substances, hazardous substances, petroleum or petroleum products, asbestos-containing materials or mould (collectively, "**Hazardous Materials**") or to the manufacture, processing, distribution, use, treatment, storage, disposal, transport or handling of Hazardous Materials (collectively, "**Environmental Laws** ");

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the Issuer and each of its Subsidiaries has all Authorisations required under any applicable Environmental Laws and is in compliance with their requirements;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) there are no pending or, to the knowledge and belief of the Issuer, threatened administrative, regulatory or judicial actions, suits, demands, demand letters, claims, liens, notices of non-compliance or violation, investigation or proceedings relating to any Environmental Law against it or any of its Subsidiaries;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) to the best of the Issuer's knowledge, there are no events or circumstances that would reasonably be expected to form the basis of an order for clean-up or remediation, or an action, suit or proceeding by any private party or governmental body or agency, against or affecting the Issuer or any of its Subsidiaries relating to Hazardous Materials or Environmental Laws; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) in the ordinary course of its business, the Issuer periodically reviews the effect of Environmental Laws on the business, operations and properties of the Issuer and each of its Subsidiaries, in the course of which the Issuer identifies and evaluates associated costs and liabilities (including, without limitation, any capital or operating expenditures required for clean-up, closure of properties or compliance with Environmental Laws or any permit, authorisation or approval, any related constraints on operating activities and any potential liabilities to third parties); on the basis of such review, the Issuer has reasonably concluded that such associated costs and liabilities would not, individually or in the aggregate, have a Material Adverse Effect;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(u) that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the Issuer and each of its Subsidiaries has in place all policies of insurance which in the reasonable opinion of the directors of the Issuer are sufficient and are customary for the conduct of their respective businesses as, and in the jurisdiction in which they are, currently operated and for compliance with all applicable requirements of law;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) such policies are in full force and effect;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) all premiums with respect to such policies which are due have been paid;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) no notice of cancellation or termination has been received with respect to any such policy; and

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) the Issuer and each of its Subsidiaries has complied with the terms and conditions of such policies;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) there are no claims by the Issuer or any of its Subsidiaries under any policy or instrument of insurance as to which any insurance company is denying liability or defending under a reservation of rights clause, and neither the Issuer nor any of its Subsidiaries has been refused any insurance coverage sought or applied; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) neither the Issuer nor any of its Subsidiaries has reason to believe that it will not be able to renew its existing insurance coverage as and when such coverage expires or to obtain similar coverage from similar insurers as may be necessary to continue its business at a cost that would not have a Material Adverse Effect;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(w) that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the Issuer and its Subsidiaries have filed all tax returns, reports and other information required to be filed by it or have properly requested extension thereof, and the Issuer and its Subsidiaries have paid all taxes required to be paid by any of them and, if due and payable, any related or similar assessment, fine or penalty levied against any of them, except as may be being contested in good faith and by appropriate proceedings. The Issuer has made adequate charges, accruals and reserves in the applicable financial statements referred to in Clause 7.1(b) (*Representations and Warranties*) in respect of all income and franchise taxes for all periods as to which the tax liability of the Issuer or any of its Subsidiaries has not been finally determined;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) no transaction, stamp duty, stamp duty reserve, registration, transfer, documentary or other similar taxes or duties are payable by or on behalf of the Initial Subscriber in Belgium (except for a stamp duty of EUR 0.15 that is payable for each original copy of an agreement containing a debt obligation, indebtedness or security interest for the benefit of banks that is signed or registered in Belgium), the United States or any other jurisdiction in which the Issuer is resident or treated as doing business in for tax purposes in each case in connection with the authorisation, execution or delivery of the First Tranche Bond Documents, the authorisation, execution, issue or delivery of the First Tranche Bonds, the issuance and delivery of Shares upon conversion of the First Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds, or the performance of the obligations of the Issuer under the First Tranche Bond Documents and the First Tranche Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) the Issuer is and has been exclusively resident for all tax purposes and subject to taxation in Belgium only, and has not at any time been resident or had any branch, agency or permanent establishment in any other jurisdiction for any tax purpose and no tax authority has ever sought to assert the same;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) neither the Issuer nor any of its Subsidiaries has incurred any liability (or has committed any actions, or events have occurred, which would subject the Issuer or any of its Subsidiaries to a liability) in respect of any tax; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) neither the Issuer nor any of its Subsidiaries has paid nor is liable to pay nor has acted (directly or through an agent or other representative) in such manner as to

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incur a liability (or potential liability) to pay any interest or penalty in connection with any tax or otherwise paid any tax after its due date for payment or become liable to pay any tax;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(x) that the Issuer and each of its Subsidiaries maintains a system of internal accounting controls which, in the reasonable opinion of the Issuer, is sufficient to provide reasonable assurance that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) transactions are executed in accordance with management's general or specific authorisations;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) transactions are recorded as necessary to (A) permit preparation of financial statements in conformity with IFRS accounting principles generally accepted in Belgium, and (B) maintain accountability for assets; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) the Issuer and each of its Subsidiaries has made and kept books, records and accounts which, in reasonable detail, accurately and fairly reflect the transactions and dispositions of assets of such entity and provide a sufficient basis for the preparation of the Issuer's consolidated financial statements in accordance with IFRS accounting principles generally accepted in Belgium;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(y) that neither the Issuer nor any of its Subsidiaries nor any of their respective directors, officers or employees nor, to the best of the Issuer's knowledge, any agent or affiliate of the Issuer or any of its Subsidiaries is currently the subject or the target of any Sanctions or conducting business with any person, entity or country which is the subject or target of any Sanctions in a manner which is prohibited by such Sanctions;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(z) that neither the Issuer nor any of its Subsidiaries nor any of their respective directors, officers or employees nor, to the best of the Issuer's knowledge, any agent or affiliate of the Issuer or any of its Subsidiaries:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) has engaged in any activity or conduct which would violate any applicable anti-bribery or anti-corruption laws or regulations (including. without limitation. to the extent applicable. the U.S. Foreign Corrupt Practices Act of 1977 or the rules and regulations promulgated thereunder. or under the UK Bribery Act 2010) ()"**Anti-Bribery and Anti-Corruption Laws** ");

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) has offered, promised, paid, received, requested or agreed to receive a bribe or other unlawful payment nor offered, promised or given any financial or other advantage to a public official (or to a third party) at the request or acquiescence of the public official in an attempt to influence them in their capacity as a public official to obtain or retain business, or to obtain an advantage in the conduct of business, where such offer, promise or payment is not permitted under applicable laws (a "**Prohibited Payment** "); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) has been or is, to the best of the Issuer's knowledge, subject to any investigation by any governmental entity, or any action, suit or proceeding by or before any court or governmental agency, authority or body or any arbitrator with regard to any actual or alleged Prohibited Payment or violation of Anti-Bribery and Anti-Corruption Laws, and, to the best of the Issuer's knowledge, no such actions, suits or proceedings are threatened or contemplated.

The Issuer has instituted, maintains and enforces systems, controls, policies and procedures for the purpose of preventing it and its directors and officers, employees and any other

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persons acting on its or their behalf from engaging in any action in breach of Anti-Bribery and Anti-Corruption Laws;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(aa) that the operations of the Issuer and each of its Subsidiaries are and have been conducted at all times in compliance with applicable financial record keeping and reporting requirements and money laundering statutes in Belgium, the European Union and of all jurisdictions in which the Issuer and each of its Subsidiaries conduct business, the rules and regulations thereunder and any related or similar rules, regulations or guidelines, issued, administered or enforced by any governmental agency and which is binding on the Issuer or any of its Subsidiaries (collectively, the "**Money Laundering Laws**") and no action, suit or proceeding by or before any court or governmental agency, authority or body or any arbitrator involving the Issuer or any of its Subsidiaries with respect to Money Laundering Laws is pending and, to the best of the Issuer's knowledge, no such actions, suits or proceedings are threatened or contemplated. The Issuer has instituted, maintains and enforces systems, controls, policies and procedures for the purpose of preventing it and its directors and officers, employees and any other persons acting on its or their behalf from engaging in any action in breach of Money Laundering Laws;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(bb) that the First Tranche Bonds will, upon issue, constitute direct, unconditional, unsubordinated (subject to Condition 1.4 (*Subordination*)) and unsecured obligations of the Issuer ranking *pari passu* and rateably, without any preference among themselves, and at least equally with all other existing and future unsecured and unsubordinated obligations of the Issuer but, in the event of an insolvency of the Issuer, save for such obligations that may be preferred by provisions of law that are mandatory and of general application;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(cc) that the Issuer has not entered, and will not enter, into any contractual arrangement with respect to the distribution of the First Tranche Bonds except for this Agreement and the Term Sheet or any supplementary or ancillary documentation related thereto;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(dd) that neither the Issuer nor any of its Subsidiaries is engaged in any transactions with its directors, officers, management, shareholders, or any other person, including persons formerly holding such positions, on terms that are not available from other parties on an arm's-length basis and otherwise are on ordinary commercial terms;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ee) that the issue and sale of the First Tranche Bonds by the Issuer on the First Tranche Closing Date will not result in a breach of any provisions relating to financial assistance, principles of corporate benefit or any similar analogous law or regulation in the jurisdictions of its incorporation which could invalidate the enforceability of the First Tranche Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ff) that the First Tranche Bonds and the issuance and delivery of Shares upon conversion of the First Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds have not been and will not be registered under the Securities Act and have not been registered or qualified under any state securities or "Blue Sky" laws of the states of the United States and, accordingly, the Issuer acknowledges that the First Tranche Bonds and the issuance and delivery of Shares upon conversion of the First Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds may not be offered or sold within the United States or to or for the account or benefit of U.S. persons except in accordance with Regulation S or pursuant to another exemption from the registration requirements of the Securities Act (terms used in this paragraph have the meaning given to them by Regulation S);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(gg) that the Issuer is a "foreign issuer" (as such term is defined in Regulation S);

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(hh) that none of the Issuer nor any of its affiliates, nor any persons acting on any of their behalf, has engaged or will engage in any directed selling efforts (as defined in Rule 902(c) under the Securities Act) with respect to the First Tranche Bonds or the Shares issuable upon exercise of any Share Settlement Option under the First Tranche Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) each of the Issuer and its affiliates will comply with the offering restrictions requirement of Regulation S under the Securities Act and will not make any offers or sales of the First Tranche Bonds or the Shares issuable upon exercise of any Share Settlement Option under the First Tranche Bonds to a US person or for the account or benefit of a US person prior to the expiration of the 40 day distribution compliance period specified in Rule 903(b)(2) of Regulation S; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(jj) no registration under the Securities Act of the First Tranche Bonds and any Shares issued and delivered upon conversion of the First Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds will be required for the offer, sale and delivery of the First Tranche Bonds and any Shares issued and delivered upon conversion of the First Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds to the Initial Subscriber in the manner contemplated by the First Tranche Bond Documents.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**7.2** **Representations and Warranties on the Second Tranche Closing Date** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Subject to paragraph (b) below, the Issuer shall make the representations and warranties set out above in Clause 7.1 (*Representations and Warranties*) to the Initial Subscriber in respect of the First Tranche Bond and the Second Tranche Bonds on the date of the Second Tranche Request Notice and, by reference to the facts and circumstances then subsisting, on the Second Tranche Closing Date and each intervening day.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) For the purposes of paragraph (a) above, the representations and warranties Clause 7.1 (*Representations and Warranties*) shall be deemed to be modified with effect from the date of the Second Tranche Request Notice as follows:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) unless otherwise modified by this Clause:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) any reference to the First Tranche Bonds shall be construed to include reference to the Second Tranche Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) any reference to the First Tranche Bond Documents shall be construed to include reference to the Second Tranche Bond Documents;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(C) any reference to the First Tranche Conditions shall be construed to include reference to the Second Tranche Conditions; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(D) any reference to the First Tranche Closing Date shall be construed to include reference to the Second Tranche Closing Date;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) Clause 7.1(k) (*Representations and Warranties*) shall be deleted in its entirety and replaced with the following words:

"that no event has occurred which would constitute (if the Second Tranche Bond Documents had been duly executed and the Second Tranche Bonds were issued and outstanding) an Event of Default, a Potential Event of Default or a Relevant Event (each as defined in the First Tranche Conditions and the Second Tranche Conditions);";

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) Clause 7.1(l) (*Representations and Warranties*) shall be deleted in its entirety and replaced with the following words:

"all required consents, approvals, authorisations, orders, filings, registrations or qualifications of or with any court or Governmental Authority or agency of Belgium, the United States or of any other jurisdiction that is applicable to the Issuer and its Subsidiaries have been given, fulfilled or done for or in connection with the execution, issue and distribution of the Second Tranche Bonds and compliance by the Issuer with the terms of the First Tranche Bonds and the Second Tranche Bonds, the issuance and delivery of Shares upon conversion of the First Tranche Bonds and the Second Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds and the Second Tranche Bonds, as the case may be, or the execution and delivery of, and compliance with the terms of, the First Tranche Bond Documents and the Second Tranche Bond Documents;"; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) Clause 7.1(bb) (*Representations and Warranties*) shall be deleted in its entirety and replaced with the following words:

"that the Second Tranche Bonds will, upon issue, and the First Tranche Bonds currently constitute direct, unconditional, unsubordinated and unsecured obligations of the Issuer ranking pari passu and rateably, without any preference among themselves, and at least equally with all other existing and future unsecured and unsubordinated obligations of the Issuer but, in the event of an insolvency of the Issuer, save for such obligations that may be preferred by provisions of law that are mandatory and of general application;".

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**8.** **Representations of the Initial Subscriber** 

The Initial Subscriber represents, warrants and confirms to the Issuer on the date of this Agreement (in the case of the First Tranche Bonds) and on the date of its acceptance of a Second Tranche Notice Request (in the case of the Second Tranche Bonds) as follows:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) that it has been duly incorporated and is validly existing and registered in its jurisdiction of incorporation and is not in liquidation, receivership or bankruptcy and it has full power and authority to execute and perform its obligations under this Agreement;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) that it understands that the First Tranche Bonds, Second Tranche Bonds, the Shares to be issued and delivered upon conversion of the First Tranche Bonds or Second Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds or Second Tranche Bonds, as the case may be, have not been and will not be registered under the Securities Act or with any securities regulatory authority of any state or other jurisdiction of the United States and that any offer and sale of the First Tranche Bonds, Second Tranche Bonds, the Shares to be issued and delivered upon conversion of the First Tranche Bonds or Second Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds or Second Tranche Bonds, as the case may be, to it is being made in reliance on an exemption from, or in a transaction not subject to, the registration requirements of the Securities;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) that its purchase of the First Tranche Bonds or Second Tranche Bonds, as the case may be, is lawful under the laws of the jurisdiction of its incorporation and the jurisdiction in which

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it operates (if different), and that such acquisition will not contravene any law, regulation or regulatory policy applicable to it;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) that it is not a U.S. person (as such term is defined in Regulation S) and is not acting for the account or benefit of a U.S. person;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) that it is not a "distributor" (as such term is defined in Regulation S);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) that it is a "qualified investor" as defined under Article 2 of Regulation (EU) 2017/1129;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) that it is acquiring the First Tranche Bonds or Second Tranche Bonds, as the case may be, for its own account, or for one or more accounts (and as to each of which it has authority to acquire the First Tranche Bonds or Second Tranche Bonds, as the case may be, and exercise sole investment discretion), for investment purposes, and not with a view to, or for resale in connection with, the distribution thereof, directly or indirectly, in whole or in part, in the United States in violation of the Securities Act and that neither it nor any account for which it is acting (if any) was formed for the specific purpose of acquiring the First Tranche Bonds or Second Tranche Bonds, as the case may be; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) that it understands that the First Tranche Bonds, Second Tranche Bonds, the Shares issuable upon conversion of the First Tranche Bonds or Second Tranche Bonds, or the Shares issuable upon exercise of any Share Settlement Option under the First Tranche Bonds or Second Tranche Bonds, as the case may be, may only be resold or otherwise transferred pursuant to an effective registration statement or in in a transaction exempt from, or not subject to, the registration requirements of the Securities Act, and in compliance with applicable state securities law, and that the Issuer is not required to register the First Tranche Bonds or the Second Tranche Bonds, as the case may be, under the Securities Act.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**9.** **Undertakings by the Issuer** 

The Issuer undertakes with the Initial Subscriber as follows:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) it will forthwith notify the Initial Subscriber if at any time anything occurs which renders or which it is aware might reasonably be expected to render untrue or incorrect in any respect any of the representations and warranties contained in Clause 7 (*Representations and Warranties*);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) to the extent that any amendments, variations or modifications are made to the constitutional documents (including its articles of association) of the Issuer, the Issuer shall forthwith promptly notify the Initial Subscriber and provide it with a copy of the updated documents and an explanation of the amendments, variations or modifications that have been made;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) between either, as the case may be,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the date hereof and the First Tranche Closing Date (both dates inclusive); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the date of the Second Tranche Request Notice and the Second Tranche Closing Date (both dates inclusive),

it will not do any act or thing which, had the First Tranche Bonds or Second Tranche Bonds (as the case may be) then been in issue, would result in an adjustment to the Conversion Price (as defined in the First Tranche Conditions or the Second Tranche Conditions, as

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applicable). In the case of the First Tranche Bonds, the foregoing sentence shall not apply to any such adjustment to the Conversion Price which, had such First Tranche Bonds then been in issue, would have been triggered by the Equity Offering;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) it will use the proceeds from the issue of the Bonds of each Series and the Equity Offering for general corporate purposes;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) to the extent any the Shares issuable upon conversion of the Bonds of either Series, or the Shares issuable upon exercise of any Share Settlement Option under the Bonds of either Series are to be delivered to any holder of such Bonds pursuant to the terms of the relevant Bond Documents (as the case may be), that such Shares shall be freely tradeable shares under applicable securities laws at the time of delivery and will not bear legends noting restrictions as to resale of such securities under US federal or state securities laws nor be subject to stop transfer instructions and such Shares will delivered to the account identified by such holder of Bonds in DTC or Euroclear Belgium in accordance with the terms and in the manner contemplated by the relevant Bond Documents;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) it will not, and it shall procure that its Subsidiaries will not, directly or indirectly use all or part of the proceeds of the offering of the Bonds of each Series and the Equity Offering, or lend, contribute or otherwise make available all or part of such proceeds to any subsidiary, joint venture partner or other person:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) to fund or facilitate any activities of or business with any person that, at the time of such funding or facilitation, is the subject or the target of applicable Sanctions;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) to fund or facilitate any activities of or business in any country or territory, that is, or whose government is, the subject of any Sanctions at the time of such funding or financing;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) in any other manner that will result in a violation by the Issuer or any of its Subsidiaries of applicable Sanctions;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) in connection with any Prohibited Payment; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) in any manner that would contravene any applicable Money Laundering Laws and Anti-Bribery and Anti-Corruption Laws;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) the Issuer will ensure that all announcements and documents published or statements made by it or on its behalf, which refer to the Initial Subscriber (including Heights Capital Management, Inc., Heights Capital Ireland, LLC and/or any of their respective affiliates) by name will only be made or published with the prior written consent of the Initial Subscriber (such consent to be withheld at the Initial Subscriber's sole and absolute discretion) and will be true and accurate in all material respects and not misleading in any material respect and, where appropriate, will contain all information necessary for legal or regulatory purposes and all opinions included will be honestly held and given after due and careful consideration. Nothing in this paragraph shall restrict the Issuer from at any time making any disclosure or announcement which is required by any applicable law, regulation, stock exchange rule, judicial or regulatory order, or any tax authority or other Governmental Authority, *provided that* where such disclosure or announcement is required and, to the extent permitted by the relevant law, regulation, stock exchange rule, judicial or regulatory order, tax authority or other Governmental Authority, the Issuer shall promptly notify the Initial Subscriber and provide to the Initial Subscriber the relevant

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announcement, document or statement for its prior review and consent (such consent not to be unreasonably withheld, conditioned or delayed);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) each of the Issuer and the Initial Subscriber acknowledge that the Issuer intends to publish (on one or more occasions) a public announcement in connection with its offering, sale and issuance of the First Tranche Bonds, the Second Tranche Bonds and the transactions contemplated by this Agreement, but in each case without referring to the Initial Subscriber (including Heights Capital Management, Inc., Heights Capital Ireland, LLC and/or any of their respective affiliates) by name (each such announcement, a "**Transaction Press Release** "). The Issuer hereby undertakings that it shall not:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) publish or otherwise make available to the public any such Transaction Press Release without the contents thereof being approved in writing by the Initial Subscriber; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) modify, vary, amend or otherwise change the content of any Transaction Press Release approved by the Initial Subscriber pursuant to paragraph (i) above without its prior consent in writing.

Nothing in this paragraph shall restrict the Issuer from at any time making any disclosure or announcement which is required by any applicable law, regulation, stock exchange rule, judicial or regulatory order, or any tax authority or other Governmental Authority, *provided that* where such disclosure or announcement is required and, to the extent permitted by the relevant law, regulation, stock exchange rule, judicial or regulatory order, tax authority or other Governmental Authority, the Issuer shall promptly notify the Initial Subscriber and provide to the Initial Subscriber the relevant announcement, document or statement for its prior review and consent (such consent not to be unreasonably withheld, conditioned or delayed); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) between the date of this Agreement and the First Tranche Closing Date (inclusive), the Issuer shall comply, and the Issuer shall procure that each of its Subsidiaries will comply, with the provisions of Condition 2 (*Covenants*) of the First Tranche Conditions.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**10.** **Notices** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**10.1** **Communications in Writing** 

Any communication to be made under or in connection with this Agreement or the Bonds of any Series shall be made in writing and, unless otherwise stated, may be made by email or letter.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**10.2** **Addresses** 

The address and email address (and the department or officer, if any, for whose attention the communication is to be made) of each Party for any communication or document to be made or delivered under or in connection with this Agreement or the Bonds of any Series is:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) in the case of the Issuer:

---

| | |
|:---|:---|
| Address: | [\*\*\*] |
| Email: | [\*\*\*]<u> </u> |
| Attention: | [\*\*\*] |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) In the case of the Initial Subscriber:

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---

| | |
|:---|:---|
| **CVI Investments, Inc.**  | **CVI Investments, Inc.**  |
| Address: | [\*\*\*] |
| Email: | [\*\*\*]<u> </u> |
| Attention: | [\*\*\*] |

---

or any substitute address or email address or department or officer as the Party may notify to the other Parties by not less than five Business Days' notice.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**10.3** **Effectiveness** 

Any notice given under this Agreement shall take effect, in the case of a letter, at the time of delivery, or in the case of email transmission, at the time of despatch (unless a delivery failure notification is received by the sender within 12 hours of sending such communication, in which case such notice shall be deemed not to have taken effect). If such delivery or despatch is made after 5:00 p.m. (Brussels time) or on a day which is not a Brussels business day (in respect of matters where only Brussels business days are specified) or Business Day (in respect of all other matters), such delivery shall be deemed to have been made on the next following Brussels business day or Business Day, as applicable.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**11.** **Confidential Information** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**11.1** **Confidentiality** 

Each Party agrees to keep all Bond Documents and their contents (the "**Confidential Information**") strictly confidential and not to disclose any Confidential Information to any person, save to the extent permitted by Clause 11.2 (*Disclosure of Confidential Information*).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**11.2** **Disclosure of Confidential Information** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Each Party may disclose Confidential Information:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) on a confidential basis to the accountants, legal counsels and other professional advisors retained by the Issuer and the Initial Subscriber, respectively; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) as required by applicable law, regulation, stock exchange rules, judicial or regulatory order, or any tax authority or other Governmental Authority, after consultation with the other Parties (to the extent permitted by the relevant law, regulation, stock exchange rule, judicial or regulatory order, tax authority or other Governmental Authority); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) to the extent that one of the Parties needs to disclose the same for the exercise, protection of enforcement of its rights under the Bond Documents or the Bonds of any Series,

and no Party may disclose Confidential Information to any other person (other than, in the case of the Initial Subscriber, any of its affiliates, agents, management entities or funds under common management or control and having made them aware of the confidential nature of such disclosures) without the prior written consent of the other Parties.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Each Bondholder may disclose Confidential Information to any person (having made them aware of the confidential nature of such disclosure) in connection with the potential transfer of Bonds or assignment or novation of their rights, benefits and/or obligations under this

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Agreement and the Bonds of any Series (or discussions in relation thereto) to any potential transferee.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**11.3** **Restricted Information** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) The Issuer shall not (without first entering into a separate confidentiality agreement with the Initial Subscriber) provide the Initial Subscriber with any Restricted Information regarding the Bonds of each Series, the Shares, the Issuer or any of its Subsidiaries.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) In relation to any Restricted Information disclosed by the Issuer (or on its behalf) to the Initial Subscriber on or prior to the First Tranche Closing Date, the Issuer shall (in consultation with the Initial Subscriber) do whatever is necessary to ensure that such Restricted Information is publicly disclosed to the market in accordance with applicable laws, regulations or rules (including, for the avoidance of doubt, by way of announcement through a Regulatory Information Service and Form 6-K (or similar)) or as otherwise may be effective so as to ensure that, by no later than the First Tranche Closing Date, the Initial Subscriber is no longer in possession of Restricted Information and is no longer restricted from trading in any securities or instruments of the Issuer or any of its Subsidiaries or any other person by reason of the receipt of that Restricted Information.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Notwithstanding Clause 11.3(b) above, the Issuer shall (in consultation with the Initial Subscriber) do whatever is necessary to ensure that such Restricted Information is publicly disclosed to the market in accordance with applicable laws, regulations or rules (including, for the avoidance of doubt, by way of announcement through a Regulatory Information Service and Form 6-K (or similar)) or as otherwise may be effective so as to ensure that, within two Brussels business days of written demand by the Initial Subscriber (acting reasonably) (which may be by email and in accordance with Clause 10 (*Notices*)), the Initial Subscriber is no longer in possession of Restricted Information and is no longer restricted from trading in any securities or instruments of the Issuer or any of its Subsidiaries or any other person by reason of the receipt of that Restricted Information.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**12.** **Payments** 

All payments in respect of the obligations of the Issuer under this Agreement shall be made free and clear of, and without withholding or deduction for or on account of, any taxes, duties, assessments or governmental charges of whatever nature imposed, levied, collected, withheld or assessed by or on behalf of, any tax jurisdiction applicable to the Issuer or any political subdivision or any authority thereof or therein having power to tax, unless such withholding or deduction is required by law. In that event, the Issuer shall pay such additional amounts as will result in the receipt by the Initial Subscriber of such amounts as would have been received by it if no such withholding or deduction had been required.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**13.** **Set-off and Counterclaims** 

The Issuer may not apply or perform any counterclaims or set-off against any payment obligations pursuant to this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**14.** **Severability** 

If any provision in or obligation under this Agreement is or becomes invalid, illegal or unenforceable in any respect under the law of any jurisdiction, that will not affect or impair (a) the

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validity, legality or enforceability under the law of that jurisdiction of any other provision in or obligation under this Agreement, and (b) the validity, legality or enforceability under the law of any other jurisdiction of that or any other provision in or obligation under this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**15.** **Remedies and Waivers** 

No failure or delay by any Party to exercise any right or remedy provided under this Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it prevent or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall prevent or restrict the further exercise of that or any other right or remedy.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**16.** **Assignment and Transfers** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**16.1** **Assignments and Transfers by the Issuer** 

The Issuer may not assign any of its rights or transfer any of its rights or obligations under this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**16.2** **Assignments and Transfers by the Initial Subscriber** 

Without prejudice to any transfer restrictions regarding the First Tranche Bonds or Second Tranche Bonds set out in the relevant Bond Documents, the Initial Subscriber may assign any of its rights or transfer by novation any of its rights and obligations under this Agreement to:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) any investment vehicle, including, any funds, feeder funds or managed accounts, currently, or from time to time after the First Tranche Closing Date, directly or indirectly managed or advised by the Initial Subscriber's investment manager or any of its affiliates or principals; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) any direct or indirect affiliates of the Initial Subscriber or any of the foregoing.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**17.** **Survival** 

The obligations of the Issuer pursuant to Clauses 5 (*Indemnification of the Initial Subscriber*), 6 (*Costs and Expenses*), 9 (*Undertakings by the Issuer*), 10 (*Notices*), 11 (*Confidential Information*), 12 (*Payments*), 14 (*Severability*), 15 (*Remedies and Waivers*), 18 (*Amendments and Waivers*), 19 (*Counterparts*), and 20 (*Governing Law and Jurisdiction*) shall survive any termination, cancellation or expiry of obligations under this Agreement (including, for the avoidance of doubt, following the consummation of this Agreement upon the occurrence of the First Tranche Closing Date or Second Tranche Closing Date, as the case may be).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**18.** **Amendments and Waivers** 

The Parties may, in their absolute discretion, agree in writing to any modification, alteration or addition to this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**19.** **Counterparts** 

This Agreement may be executed in any number of counterparts, and this has the same effect as if the signatures on the counterparts were on a single copy of this Agreement.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**20.** **Governing Law and Jurisdiction** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**20.1** **Governing Law** 

This Agreement, and any non-contractual obligations arising out of or in connection with it, are and shall be governed by, and construed in accordance with, English law.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**20.2** **Jurisdiction** 

The Issuer agrees for the benefit of the Initial Subscriber that the courts of England shall have exclusive jurisdiction to hear and determine any suit, action or proceedings arising out of or in connection with this Agreement (including any non-contractual obligations arising out of or in connection with this Agreement) ("**Proceedings**") and, for such purposes, irrevocably submits to the jurisdiction of such courts. Nothing in this paragraph shall (or shall be construed so as to) limit the right of the Initial Subscriber to take Proceedings in any other court of competent jurisdiction, nor shall the taking of Proceedings in any one or more jurisdictions preclude the taking of Proceedings by the Initial Subscriber in any other jurisdiction (whether concurrently or not) if and to the extent permitted by law.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**20.3** **Appropriate Forum** 

For the purpose of Clause 20.2 (*Jurisdiction*), the Issuer irrevocably waives any objection which it might now or hereafter have to the courts of England being nominated as the forum to hear and determine any Proceedings and agrees not to claim that any such court is not a convenient or appropriate forum.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**20.4** **Service of Process** 

The Issuer agrees that the process by which any Proceedings are commenced in England pursuant to Clause 20.2 (*Jurisdiction*) may be served on it by being delivered to the Process Agent at its registered office from time to time. If such person is not or ceases to be effectively appointed to accept service of process on behalf of the Issuer, the Issuer shall promptly appoint a further person in England to accept service of process on its behalf. Nothing in this paragraph shall affect the right of the Initial Subscriber to serve process in any other manner permitted by law.

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**Schedule 1**

**First Tranche Conditions Precedent**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. **Approvals and Authorisations** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) A copy of the deed of incorporation and the latest coordinated version of the articles of association of the Issuer.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) A copy of (i) an extract from the Crossroads Bank for Enterprises (*Kruispuntbank van Ondernemingen/Banque-Carrefour des Entreprises*) and (ii) an online search on the website of the Central Solvency Register (*Centraal Register Solvabiliteit/Registre Central de la Solvabilité*), each of items (i) and (ii) above being no older than one Business Day prior to the date of this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) A certified copy of the resolutions of the general meetings of the shareholders of the Issuer authorising the board of directors of the Issuer to issue new Shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) A certified copy of a resolution of the board of directors of the Issuer:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) approving and ratifying the execution of the First Tranche Bond Documents, the issue of the First Tranche Bonds and the consummation of the transactions contemplated by the First Tranche Bond Documents and the Equity Offering;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) authorising a specified person or persons to execute the First Tranche Bond Documents to which it is a party on its behalf; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) authorising a specified person or persons, on its behalf, to sign and/or despatch all documents and notices to be signed and/or despatched by it under or in connection with the First Tranche Bond Documents to which it is a party.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) A certified copy of the reports of the Issuer's board of directors and statutory auditor related to the issue of the First Tranche Bonds

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) A copy of the nihil obstat letter from the Belgian Financial Services and Markets Authority related to the above reports or, in the case the Belgian Financial Services and Markets Authority has not responded within 15 calendar days after filing such reports, a certification in writing by the Issuer that no comments were raised by the Belgian Financial Services and Markets Authority.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) A list of the specimen of the signature of each person authorised by the resolution referred to in paragraph (ii) above.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. **Legal opinion** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Legal opinion of NautaDutilh BV/SRL, legal advisers to the Issuer as to matters of Belgian law, substantially in a form and substance satisfactory to Initial Subscriber.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Legal opinion of the legal advisers to the Issuer as to matters of English law, substantially in a form and substance satisfactory to Initial Subscriber.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3. **Other documents and evidence** 

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) An executed copy of each of the First Tranche Bond Documents (other than the First Tranche Bond Certificate).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) A certificate dated the First Tranche Closing Date and signed by a Director of the Issuer certifying the truth and accuracy of the approvals and authorisations of the Issuer and an extract of the First Tranche Register, in substantially the form set out in Schedule 4 (*Form of Corporate Certificate*).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) A certificate dated the First Tranche Closing Date and signed by a Director of the Issuer confirming, among other things, the matters specified in Clauses 3.1(a)(ii), 3.1(a)(iii) and 3.1(a)(iv) (*Conditions Precedent to First Tranche Closing*), substantially in the form set out in Schedule 5 (*Form of Closing Certificate*).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) The satisfaction of all of the Initial Subscriber's necessary "know your customer" and/or other similar checks under its internal requirements and applicable laws and regulations (which is currently expected to be provision of a completed W-8 BEN-E (or W-9) tax form from the Issuer or any other account recipient, contacts in the Issuer who can verify wire transfer details and signed bank account details on the Issuer's letterhead), in relation to this Agreement, the First Tranche Bonds and the transactions contemplated thereby and the Issuer has provided all such relevant information in relation thereto.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) A written acceptance of a process agent of its appointment in respect of this Agreement and the First Tranche Bond Documents as set out therein.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) Confirmation that the entering into of the First Tranche Bond Documents and issuance of the First Tranche Bonds and performance of obligations thereunder is not restricted by and does not result in any breach of or non-compliance with the terms of the agreements between the Issuer and the European Investment Bank (including as to which limb of paragraph 15 of Schedule H of the EIB Facility (as defined in the First Tranche Conditions) applies to the First Tranche Bonds), in a form and substance satisfactory to Initial Subscriber.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) A copy of any other authorisation or other document, opinion or assurance which the Initial Subscriber considers (in good faith) to be reasonably necessary (if it has notified the Issuer accordingly within a reasonable time) in connection with the entry into and performance of the transactions contemplated by any First Tranche Bond Document or for the validity and enforceability of any First Tranche Bond Document.

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**Schedule 2**

**Second Tranche Conditions Precedent**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. **Approvals and Authorisations** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) A copy of the deed of incorporation and the latest coordinated version of the articles of association of the Issuer.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) A copy of (i) an extract from the Crossroads Bank for Enterprises (*Kruispuntbank van Ondernemingen/Banque-Carrefour des Entreprises*) and (ii) an online search on the website of the Central Solvency Register (*Centraal Register Solvabiliteit/Registre Central de la Solvabilité*), each of items (i) and (ii) above being no older than one Business Day prior to the date of this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) A certified copy of the resolutions of the general meetings of the shareholders of the Issuer authorising the board of directors of the Issuer to issue new Shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) A copy of a resolution of the board of directors of the Issuer:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) approving and ratifying the execution of the Second Tranche Bond Documents, the issue of the Second Tranche Bonds and the consummation of the transactions contemplated by the Second Tranche Bond Documents;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) authorising a specified person or persons to execute the Second Tranche Bond Documents on its behalf; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) authorising a specified person or persons, on its behalf, to sign and/or despatch all documents and notices to be signed and/or despatched by it under or in connection with the Second Tranche Bond Documents;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) A certified copy of the reports of the Issuer's board of directors and statutory auditor related to the issue of the Second Tranche Bonds.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) A copy of the nihil obstat letter from the Belgian Financial Services and Markets Authority related to the above reports or, in the case the Belgian Financial Services and Markets Authority has not responded within 15 calendar days after filing such reports, a certification in writing by the Issuer that no comments were raised by the Belgian Financial Services and Markets Authority.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) A list of the specimen of the signature of each person authorised by the resolution referred to in paragraph (ii) above  *.*** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. **Legal opinion** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Legal opinion of NautaDutilh BV/SRL, legal advisers to the Issuer as to matters of Belgian law, substantially in a form and substance satisfactory to Initial Subscriber.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Legal opinion of the legal advisers to the Issuer as to matters of English law, substantially in a form and substance satisfactory to Initial Subscriber.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3. **Other documents and evidence** 

------

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) An executed copy of each of the Second Tranche Bond Documents (other than the Second Tranche Bond Certificate).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) A certificate dated the Second Tranche Closing Date and signed by a Director of the Issuer certifying the truth and accuracy of the approvals and authorisations of the Issuer and an extract of the Second Tranche Register, in substantially the form set out in Schedule 4 (*Form of Corporate Certificate*).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) A certificate dated the Second Tranche Closing Date and signed by a Director of the Issuer confirming, among other things, the matters specified in Clauses 4.5(a)(ii), 4.5(a)(iii) and 4.5(a)(iv) (*Conditions Precedent to Second Tranche Closing*), substantially in the form set out in Schedule 5 (*Form of Closing Certificate*).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) A written acceptance of a process agent of its appointment in respect of the Second Tranche Bond Documents as set out therein.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) Confirmation that the entering into of the Second Tranche Bond Documents and issuance of the Second Tranche Bonds and performance of obligations thereunder is not restricted by and does not result in any breach of or non-compliance with the terms of the agreements between the Issuer and the European Investment Bank (including as to which limb of paragraph 15 of Schedule H of the EIB Facility (as defined in the Second Tranche Conditions) applies to the Second Tranche Bonds), in a form and substance satisfactory to Initial Subscriber.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) A copy of any other authorisation or other document, opinion or assurance which the Initial Subscriber considers (in good faith) to be reasonably necessary (if it has notified the Issuer accordingly within a reasonable time) in connection with the entry into and performance of the transactions contemplated by any Second Tranche Bond Document or for the validity and enforceability of any Second Tranche Bond Document.

------

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**Schedule 3**

**Form of Second Tranche Request Notice**

To: CVI Investments, Inc. (the "**Initial Subscriber**")

[●]<sup>1</sup>

To whom it may concern,

**Second Tranche of €-denominated Amortising Senior Unsecured Convertible Bonds to be issued by Nyxoah SA (the "Issuer")**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. We refer to the Subscription Agreement between the Issuer and the Initial Subscriber dated 13 November 2025 (as amended or supplemented from time to time, the "**Subscription Agreement** "). This is a Second Tranche Request Notice. Terms defined in the Subscription Agreement have the same meaning in this Second Tranche Request Notice, unless otherwise defined herein.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. Subject to the terms and conditions of the Subscription Agreement, we hereby notify you that we shall issue, for your subscription, Second Tranche Bonds on the following terms:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Principal Amount of Second Tranche Bonds: €22,500,000<sup>2</sup>

(b) Second Tranche Closing Date is [●] 20[●]<sup>3</sup> (or such date as may be agreed in writing (including by email) between the Parties).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3. This Second Tranche Request Notice is irrevocable.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4. This Second Tranche Request Notice and any non-contractual obligations arising out of or in connection with it shall be governed by, and construed in accordance with, English law.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5. The provisions of Clause 20 (*Governing Law and Jurisdiction*) of the Subscription Agreement shall apply (with any necessary changes to such provisions being made) to this Second Tranche Request Notice as if set out fully herein.

Yours faithfully,

------

*duly authorised*

for and on behalf of

**NYXOAH SA**

------

<sup>1</sup> *Note: This Notice must be delivered no later than five Business Days prior to the proposed Second Tranche Closing Date.*

<sup>2</sup> *Note: If the principal amount is intended to be less than €22,500,000, the Initial Subscriber's agreement must be obtained before this notice is delivered.*

<sup>3</sup> *Note: Must be no later than five Business Days from the date of this notice, unless otherwise agreed in writing by the Initial Bondholder.*

------

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**Schedule 4**

**Form of Corporate Certificate**

*[Letterhead of the Issuer]*

**Corporate Certificate**

**CVI Investments, Inc.**

c/o Heights Capital Management, Inc.

101 California Street, Suite 3250

San Francisco, CA 94111

United States of America

[*Closing Date*]

To whom it may concern,

**Nyxoah SA (the "Issuer")**

 **€-denominated Amortising Senior Unsecured Convertible Bonds**

I hereby certify that attached hereto is a true and up-to-date copy of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the deed of incorporation and the latest coordinated version of the articles of association of the Issuer;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) an extract from the Crossroads Bank for Enterprises (*Kruispuntbank van Ondernemingen/Banque-Carrefour des Entreprises*); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) an online search on the website of the Central Solvency Register (*Centraal Register Solvabiliteit/Registre Central de la Solvabilité*),

in each case, not being older than one Business Day prior to the date hereof;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) the resolutions of the general meetings of the shareholders of the Issuer authorising the board of directors of the Issuer to issue new Shares;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) a resolution of the board of directors of the Issuer:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) approving and ratifying the execution of the [First Tranche]/[Second Tranche] Bond Documents, the issue of the [First Tranche]/[Second Tranche] Bonds and the consummation of the transactions contemplated by the [First Tranche]/[Second Tranche] Bond Documents and the Equity Offering;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) authorising a specified person or persons to execute the [First Tranche]/[Second Tranche] Bond Documents to which it is a party on its behalf; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) authorising a specified person or persons, on its behalf, to sign and/or despatch all documents and notices to be signed and/or despatched by it under or in connection with the [First Tranche]/[Second Tranche] Bond Documents to which it is a party;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) the certified reports of the Issuer's board of directors and statutory auditor related to the issue of the [First Tranche]/[Second Tranche] Bonds;

------

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) [the nihil obstat letter from the Belgian Financial Services and Markets Authority related to the above reports;]<sup>4</sup>

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) the specimen of the signature of each person authorised by the resolution referred to in paragraph (ii) above; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) the [First Tranche]/[Second Tranche] Register.

Terms used herein and defined in the Subscription Agreement (as amended or supplemented from time to time) between the Issuer and CVI Investments, Inc. dated 13 November 2025 are used herein as so defined.

---

| |
|:---|
| Yours faithfully, |
| *duly authorised* |
| for and on behalf of |
| **NYXOAH SA** |

---

------

<sup>4</sup> *Delete if not applicable and include equivalent certification in the Closing Certificate.*

------

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**Schedule 5**

**Form of Closing Certificate**

[*Letterhead of the Issuer*]

**Closing Certificate**

**CVI Investments, Inc.**

c/o Heights Capital Management, Inc.

101 California Street, Suite 3250

San Francisco, CA 94111

United States of America

[*Closing Date*]

To whom it may concern,

**Nyxoah SA (the "Issuer")**

 **€-denominated Amortising Senior Unsecured Convertible Bonds**

In accordance with the Subscription Agreement between the Issuer and CVI Investments, Inc. dated 13 November 2025 (as amended or supplemented from time to time, the "**Subscription Agreement**"), the undersigned, being a duly authorised officer of the Issuer, hereby certifies that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the representations and warranties of the Issuer in the Subscription Agreement are true, accurate and correct at, and as if made on, the date hereof;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the Issuer has in all material respects performed all of its obligations under the Subscription Agreement to be performed on or before the date hereof;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) there has been no material breach of any of the obligations of the Issuer under the Subscription Agreement;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) as at the date of this certificate, no Default is continuing or would result from the issue of the [First Tranche]/[Second Tranche] Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) there has been no Material Adverse Change;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) [no comments were raised by the Belgian Financial Services and Markets Authority in connection with the reports of the Issuer's board of directors and statutory auditor relating to the issue of the [First Tranche]/[Second Tranche] Bonds;]<sup>5</sup> and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) the terms of the finance contract dated 3 July 2024 and the synthetic warrant agreement dated 15 July 2024 between the Issuer and the European Investment Bank in each case do not include any restrictions, prohibitions or other limitations that would impede or otherwise adversely affect the Issuer's ability to make payments under the [First Tranche]/[Second Tranche] Bonds in cash.

------

<sup>5</sup> *Delete if not applicable.*

------

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

Terms used herein and defined in the Subscription Agreement are used herein as so defined.

---

| |
|:---|
| Yours faithfully, |
| *duly authorised* |
| for and on behalf of |
| **NYXOAH SA** |

---

------

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

This Agreement has been executed on the date stated at the beginning.

---

| | | |
|:---|:---|:---|
| **NYXOAH SA** |  |  |
| as ***Issuer*** | ![Graphic](nyxh-20251231xex4d20005.jpg)<br>| <br>By:<br>Name:<br>*Authorised Signatory* |
|  | ![Graphic](nyxh-20251231xex4d20005.jpg)<br>| <br>By:<br>Name:<br>*Authorised Signatory* |

---

*(Signature Page to the Subscription Agreement)*

------

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

---

| | | |
|:---|:---|:---|
| **CVI INVESTMENTS, INC.** |  |  |
| as ***Initial Subscriber*** acting by Heights Capital Management, Inc., its authorised agent | ![Graphic](nyxh-20251231xex4d20005.jpg)<br>| <br>By:<br>Name: Martin Kobinger<br>Title: President |

---

*(Signature Page to the Subscription Agreement)*

------

## Exhibit 4.21

**Exhibit 4.21**

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**16 December 2025**

**Amendment and Restatement Agreement**

In respect of the Original Subscription Agreement

between

**Nyxoah SA**

as Issuer

**CVI Investments, Inc.**

as Initial Subscriber

------

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**Table of Contents**

1. Definitions and Interpretation 3

2. Amendment and Restatement 3

3. Costs and Expenses 4

4. Notices 4

5. Severability 4

6. Counterparts 4

7. Contracts (Rights of Third Parties) Act 1999 4

8. Governing Law and Jurisdiction 4

------

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**This Agreement** is made on 16 December 2025

**Between:**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) **Nyxoah SA**, a public limited liability company incorporated and existing under the laws of Belgium, registered with the Crossroads Bank for Enterprises (Kruispuntbank van Ondernemingen/Banque-Carrefour des Entreprises) under number 0817149675 (Register of Legal Entities Brabant Wallon), whose registered office is at Rue Edouard Belin 12, 1435 Mont-Saint-Guibert, Belgium (the "**Issuer** "); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) **CVI INVESTMENTS INC.**, a Cayman Islands exempted company (the "**Initial Subscriber** "),

**Whereas:**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) The Issuer and the Initial Subscriber entered into a subscription agreement dated 13 November 2025 (the "**Original Subscription Agreement** ").

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) The parties hereto are entering into this Agreement in order to amend and restate the Original Subscription Agreement.

**It is agreed** as follows:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**1.** **Definitions and Interpretation** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**1.1** **Definitions** 

**In this Agreement, the term:**

"**Amended and Restated Subscription Agreement**" means the Original Subscription Agreement as amended and restated by this Agreement in the form set out in Annex 1 (*Form of Amended and Restated Bond Agreement*).

"**Original Subscription Agreement**" has the meaning given to it in Recital (A).

Terms defined in the Amended and Restated Subscription Agreement shall have the same meaning herein, unless otherwise defined herein or the context otherwise requires.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**1.2** **Construction** 

The principles of construction set out in clause 1.2 (*Interpretation*) of the Amended and Restated Subscription Agreement shall have effect as if set out in this Agreement, *mutatis mutandis,* and in addition any reference in this Agreement to an Annex is, unless otherwise stated, to an Annex hereof and the Annexes form an integral part of this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**2.** **Amendment and Restatement** 

With effect at and from the date of this Agreement, each of the Issuer and the Initial Subscriber consents and agrees that the Original Subscription Agreement will be amended and restated in its entirety so that it reads and is construed for all purposes as set out in Annex 1 (*Form of Amended and Restated Subscription Agreement).* Save as amended by this Agreement, the provisions of the Original Subscription Agreement, the obligations of the Parties and all the rights of the Issuer and the Initial Subscriber thereunder shall continue in full force and effect and this Agreement and the Amended and Restated Subscription Agreement shall be read and construed as one instrument.

------

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**3.** **Costs and Expenses** 

Each of the Issuer and the Initial Subscriber agree that the Issuer shall be responsible for any reasonable costs and expenses (including legal fees) properly incurred by the Initial Subscriber in connection with (a) the preparation, negotiation or execution of this Agreement, and (b) any such costs and expenses incurred as a result of the extension by the Issuer of the First Tranche Closing Date (as defined in the Amended and Restated Subscription Agreement) beyond the date contemplated by the Original Subscription Agreement. Any such amount shall be deducted by the Initial Subscriber from the Subscription Price for the First Tranche Bonds in accordance with the terms of the Amended and Restated Subscription Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**4.** **Notices** 

The provisions of clause 10 (*Notices*) of the Original Subscription Agreement shall be incorporated into this Agreement as if set out in full in this Agreement and as if references therein to "this Agreement" were references to this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**5.** **Severability** 

In case any provision in or obligation under this Agreement shall be invalid, illegal or unenforceable in any jurisdiction, the validity, legality and enforceability of the remaining provisions or obligations, or of such provision or obligation in any other jurisdiction, shall not in any way be affected or impaired thereby.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**6.** **Counterparts** 

This Agreement may be executed in any number of counterparts, each of which shall be deemed to be an original and all of which together shall constitute one and the same instrument.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**7.** **Contracts (Rights of Third Parties) Act 1999** 

A Person who is not a party to this Agreement has no right under the Contracts (Rights of Third Parties) Act 1999 to enforce any term of this Agreement, but this does not affect any right or remedy of a third party which exists or is available apart from that Act.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**8.** **Governing Law and Jurisdiction** 

This Agreement and any non-contractual obligations arising out of or in connection with it shall be governed by, and construed in accordance with, English law. The provisions of clause 21 (*Governing Law and Jurisdiction*) of the Original Subscription Agreement shall apply to this Agreement as if the same were repeated in full herein, *mutatis mutandis*.

------

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**This Agreement** has been entered into on the date stated at the beginning.

**NYXOAH SA**

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;as ***Issuer*** | &nbsp;&nbsp;<br>![Graphic](nyxh-20251231xex4d21001.jpg)<br>| &nbsp;&nbsp;<br>By:<br>Name:<br>*Authorised Signatory* |
|  | &nbsp;&nbsp;<br>![Graphic](nyxh-20251231xex4d21001.jpg)<br>| &nbsp;&nbsp;<br>By:<br>Name:<br>*Authorised Signatory* |

---

*[Signature Page to the Amendment and Restatement Agreement]*

------

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**CVI INVESTMENTS, INC.**

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;as ***Initial Subscriber*** acting by Heights Capital Management, Inc., its authorised agent<br>| &nbsp;&nbsp;<br>![Graphic](nyxh-20251231xex4d21001.jpg)<br>| &nbsp;&nbsp;<br>By:<br>Name: Martin Kobinger<br>Title: President |

---

*[Signature Page to the Amendment and Restatement Agreement]*

------

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**ANNEX 1 – Form of Amended and Restated Subscription Agreement**

[*Begins on the following page*]

------

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

![Graphic](nyxh-20251231xex4d21004.jpg)

**Subscription Agreement**

in respect of the commitment to subscribe and the issuance of €-denominated

Amortising Senior Unsecured Convertible Bonds

between

**Nyxoah SA**

as Issuer

**CVI Investments, Inc.**

as Initial Subscriber

White & Case LLP

5 Old Broad Street

London EC2N 1DW

------

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**Table of Contents**

---

| | | | |
|:---|:---|:---|:---|
|  |  |  | &nbsp;&nbsp;**Page** |
| &nbsp;&nbsp;1. | &nbsp;&nbsp;Definitions and Interpretation | &nbsp;&nbsp;Definitions and Interpretation | &nbsp;&nbsp;2 |
| &nbsp;&nbsp;2. | &nbsp;&nbsp;Issue and Subscription of the First Tranche Bonds | &nbsp;&nbsp;Issue and Subscription of the First Tranche Bonds | &nbsp;&nbsp;10 |
| &nbsp;&nbsp;3. | &nbsp;&nbsp;Completion and Settlement | &nbsp;&nbsp;Completion and Settlement | &nbsp;&nbsp;10 |
| &nbsp;&nbsp;4. | &nbsp;&nbsp;Issue and Subscription of the Second Tranche Bonds | &nbsp;&nbsp;Issue and Subscription of the Second Tranche Bonds | &nbsp;&nbsp;13 |
| &nbsp;&nbsp;5. | &nbsp;&nbsp;Indemnification of the Initial Subscriber | &nbsp;&nbsp;Indemnification of the Initial Subscriber | &nbsp;&nbsp;17 |
| &nbsp;&nbsp;6. | &nbsp;&nbsp;Costs and Expenses | &nbsp;&nbsp;Costs and Expenses | &nbsp;&nbsp;19 |
| &nbsp;&nbsp;7. | &nbsp;&nbsp;Representations and Warranties of the Issuer | &nbsp;&nbsp;Representations and Warranties of the Issuer | &nbsp;&nbsp;20 |
| &nbsp;&nbsp;8. | &nbsp;&nbsp;Representations of the Initial Subscriber | &nbsp;&nbsp;Representations of the Initial Subscriber | &nbsp;&nbsp;32 |
| &nbsp;&nbsp;9. | &nbsp;&nbsp;Undertakings by the Issuer | &nbsp;&nbsp;Undertakings by the Issuer | &nbsp;&nbsp;33 |
| &nbsp;&nbsp;10. | &nbsp;&nbsp;Notices | &nbsp;&nbsp;Notices | &nbsp;&nbsp;35 |
| &nbsp;&nbsp;11. | &nbsp;&nbsp;Confidential Information | &nbsp;&nbsp;Confidential Information | &nbsp;&nbsp;36 |
| &nbsp;&nbsp;12. | &nbsp;&nbsp;Payments | &nbsp;&nbsp;Payments | &nbsp;&nbsp;37 |
| &nbsp;&nbsp;13. | &nbsp;&nbsp;Set-off and Counterclaims | &nbsp;&nbsp;Set-off and Counterclaims | &nbsp;&nbsp;37 |
| &nbsp;&nbsp;14. | &nbsp;&nbsp;Severability | &nbsp;&nbsp;Severability | &nbsp;&nbsp;37 |
| &nbsp;&nbsp;15. | &nbsp;&nbsp;Remedies and Waivers | &nbsp;&nbsp;Remedies and Waivers | &nbsp;&nbsp;37 |
| &nbsp;&nbsp;16. | &nbsp;&nbsp;Assignment and Transfers | &nbsp;&nbsp;Assignment and Transfers | &nbsp;&nbsp;37 |
| &nbsp;&nbsp;17. | &nbsp;&nbsp;Survival | &nbsp;&nbsp;Survival | &nbsp;&nbsp;38 |
| &nbsp;&nbsp;18. | &nbsp;&nbsp;Amendments and Waivers | &nbsp;&nbsp;Amendments and Waivers | &nbsp;&nbsp;38 |
| &nbsp;&nbsp;19. | &nbsp;&nbsp;Counterparts | &nbsp;&nbsp;Counterparts | &nbsp;&nbsp;38 |
| &nbsp;&nbsp;20. | &nbsp;&nbsp;Entire Agreement | &nbsp;&nbsp;Entire Agreement | &nbsp;&nbsp;38 |
| &nbsp;&nbsp;21. | &nbsp;&nbsp;Governing Law and Jurisdiction | &nbsp;&nbsp;Governing Law and Jurisdiction | &nbsp;&nbsp;38 |
| &nbsp;&nbsp;**Schedule 1** | &nbsp;&nbsp;**Schedule 1** | &nbsp;&nbsp;**First Tranche Conditions Precedent** | &nbsp;&nbsp;**40** |
| &nbsp;&nbsp;**Schedule 2** | &nbsp;&nbsp;**Schedule 2** | &nbsp;&nbsp;**Second Tranche Conditions Precedent** | &nbsp;&nbsp;**42** |
| &nbsp;&nbsp;**Schedule 3** | &nbsp;&nbsp;**Schedule 3** | &nbsp;&nbsp;**Form of Second Tranche Request Notice** | &nbsp;&nbsp;**44** |
| &nbsp;&nbsp;**Schedule 4** | &nbsp;&nbsp;**Schedule 4** | &nbsp;&nbsp;**Form of Corporate Certificate** | &nbsp;&nbsp;**45** |
| &nbsp;&nbsp;**Schedule 5** | &nbsp;&nbsp;**Schedule 5** | &nbsp;&nbsp;**Form of Closing Certificate** | &nbsp;&nbsp;**47** |

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**This Agreement** is made on 13 November 2025 and is amended and restated on 16 December 2025

**Between:**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3) **Nyxoah SA**, a public limited liability company incorporated and existing under the laws of Belgium, registered with the Crossroads Bank for Enterprises (Kruispuntbank van Ondernemingen/Banque-Carrefour des Entreprises) under number 0817149675 (Register of Legal Entities Brabant Wallon), whose registered office is at Rue Edouard Belin 12, 1435 Mont-Saint-Guibert, Belgium (the "**Issuer** "); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(4) **CVI INVESTMENTS INC.**, a Cayman Islands exempted company (the "**Initial Subscriber** "),

(each a "**Party**" and together, the "**Parties**").

**Whereas:**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) The Issuer proposes to issue €22,500,000 amortising senior unsecured convertible bonds due 2028 (the "**First Tranche Bonds**") to be constituted by a bond instrument to be entered into not later than the First Tranche Closing Date (as defined below) by the Issuer (in the agreed form and as may be supplemented or amended from time to time, the "**First Tranche Bond Instrument** "), and subject to the terms and conditions set out in the First Tranche Bond Instrument (in the agreed form) (the "**First Tranche Conditions** ").

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) Prior to the issue of the First Tranche Bonds, the Issuer shall conduct a primary placing of newly issued ordinary shares of the Issuer with no nominal value per share (the "**Shares**") in number resulting in no less than gross proceeds of €20,000,000 (inclusive of the proceeds to be received from the Initial Subscriber in relation to its proposed subscription of such Shares) pursuant to an equity offering by the Issuer, with all such sales of Shares to be at the same placing price (the "**Placing Price**" and the "**Equity Offering** ", respectively). The Initial Subscriber intends to participate in the Equity Offering and subscribe for Shares (at the Placing Price) in number resulting in a gross subscription price of approximately €4,000,000.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(C) Following the First Tranche Closing Date (as defined below), and subject to the terms of this Agreement, the Issuer may create and issue one additional series of amortising senior unsecured convertible bonds, with such series having an aggregate principal amount series of €22,500,000. This additional series will be referred to as the "**Second Tranche Bonds** ", and together with the First Tranche Bonds, they will be collectively referred to as the "**Bonds**" and each a "**Series** ".

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(D) Subject to the provisions of the First Tranche Conditions, the First Tranche Bonds will be convertible into Shares at the Conversion Price (as defined in the First Tranche Conditions), subject to adjustment in accordance with the First Tranche Conditions. Payments of principal instalment amounts and interest amounts on the First Tranche Bonds shall in certain circumstances (subject to and in accordance with the First Tranche Conditions) be settled by the issuance of Shares as provided in the First Tranche Conditions.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(E) The Second Tranche Bonds are intended to be issued on substantially the same terms as the First Tranche Bonds, subject as otherwise provided in this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(F) The Parties hereto wish to record the arrangements agreed between them in relation to the commitment to subscribe for the Bonds of each Series by the Initial Subscriber and the issue of the Bonds of each Series by the Issuer.

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**It is agreed:**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**1.** **Definitions and Interpretation** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**1.1** **Definitions** 

In this Agreement, the following terms shall have the following meanings:

"**€**" or "**EUR**" means the euro currency introduced at the start of the third stage of European economic and monetary union, and as defined in Article 2 of Council Regulation (EC) No 974/98 of 3 May 1998 on the introduction of the euro, as amended.

"**affiliate**" has the meaning given to it in Rule 501(b) of Regulation D under the Securities Act.

"**Agreed Expenses**" means:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) any costs and expenses payable by the Issuer in accordance with Clause 6.1(b) (*Costs and Expenses*), but excluding any Deposited Amounts that have been paid by the Issuer prior to the date of this Agreement in accordance with the Term Sheet; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) solely in the case of the First Tranche Closing Date, any costs and expenses payable by the Issuer in accordance with clause 3 (*Costs and Expenses*) of the Amendment and Restatement Agreement.

"**Amendment and Restatement Agreement**" means the amendment and restatement agreement in respect of this Agreement dated 16 December 2025 between the Parties.

"**Anti-Bribery and Anti-Corruption Laws**" has the meaning given in Clause 7.1(z)(i) (*Representations and Warranties*).

"**Authorisation**" means an authorisation, consent, approval, resolution, licence, exemption, filing, notarisation or registration.

"**Average Market Capitalisation**" means the arithmetic average of the market capitalisation of the Issuer based on the Closing Price (as defined in the First Tranche Conditions) of a Share on each of the 30 consecutive dealing days (as defined in the First Tranche Conditions) ending on (and including) the dealing day immediately preceding the First Tranche Closing Date, as published by or derived from Bloomberg page HP (or any successor page) (setting 'RR902 Current Market Cap', or any other successor setting) (and for the avoidance of doubt as at the date of this Agreement such Bloomberg page for the Shares is NYXH BB Equity HP), as determined by the Calculation Agent, if available or, in any other case, such other source (if any) as shall be agreed in writing (including by email) between the Issuer and the Initial Subscriber (each acting reasonably), and the Market Capitalisation determined as aforesaid on any dealing day shall, if not in EUR, be translated by the Calculation Agent into EUR at the Prevailing Rate (as defined in the First Tranche Conditions) on such dealing day.

"**Belgian Code of Companies and Associations**" means the Belgian Code of Companies and Associations (*Wetboek van vennootschappen en verenigingen*/*Code des sociétés et associations*), as amended from time to time.

"**Bond Documents**" means the First Tranche Bond Documents and the Second Tranche Bond Documents, as the context may require.

"**Bonds**" has the meaning given to it in Recital (B).

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

"**Business Day**" means a day (other than a Saturday or Sunday) on which banks are open for general non-automated business in Brussels and New York.

"**Calculation Agent**" means Conv-Ex Advisors Limited.

"**Confidential Information**" has the meaning given in Clause 11.1 (*Confidentiality*).

"**Default**" means an Event of Default or any event or circumstance specified in Condition 10 (*Events of Default*) of the Bonds of each applicable Series which would (with the expiry of a grace period, the giving of notice, the making of any determination under the relevant Bond Documents or any combination of any of the foregoing) be an Event of Default.

"**Deposited Amount**" has the meaning given in the Term Sheet.

"**DTC**" means The Depository Trust Company, a limited purpose trust company organised under the laws of the State of New York, and its successors and assigns.

"**Equity Offering**" has the meaning given to it in Recital (B).

"**Euroclear Belgium**" means Caisse Interprofessionnelle de Dépôts et de Virements de Titres SA/Interprofessionnele Effectendepositen Girokas NV (C.I.K.) (commercial name Euroclear Belgium), enterprise number 0403 206 432 (Register of Legal Entities for Brussels), or any entity replacing the same as a central securities depository.

"**Excluded Instrument**" means any of the following:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the 1,400,000 subscription rights (*inschrijvingsrechten / droits de souscription*) issued by the Issuer on 8 September 2021 pursuant to the 2021 warrants plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the 700,000 subscription rights (*inschrijvingsrechten / droits de souscription*) issued by the Issuer on 28 December 2022 pursuant to the 2022 warrants plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) the 1,000,000 subscription rights (*inschrijvingsrechten / droits de souscription*) issued by the Issuer on 31 July 2024 pursuant to the 2024 warrants plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) the 805,000 subscription rights (*inschrijvingsrechten / droits de souscription*) issued by the Issuer on 30 January 2025 pursuant to the 2025 warrants plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) the 760,000 subscription rights (*inschrijvingsrechten / droits de souscription*) issued by the Issuer on 13 October 2025 pursuant to the 2025-2 warrants plan; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) the subscription rights (*inschrijvingsrechten / droits de souscription*), Shares, or restricted stock units to be issued or granted to directors of personnel of the Issuer (or its affiliates) from time to time in accordance with the remuneration policy of the Issuer, as amended; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) any subscription rights (*inschrijvingsrechten / droits de souscription*) that may be issued from time to time under any other personnel incentive plan,

*provided that,* on any date, (x) the Excluded Instruments, taken together, shall not entitle the beneficiaries thereof the right to subscribe for, acquire, or otherwise receive Shares in an aggregate number exceeding 10.0 per cent. of the Issuer's issued share capital (it being understood that any such subscription rights (*inschrijvingsrechten / droits de souscription*), Shares or restricted stock units issued in excess of the foregoing limitation shall not constitute an Excluded Instrument), and (y) in the case of paragraphs (g) and (h), the issuance of such subscription rights

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

(*inschrijvingsrechten / droits de souscription*), Shares or restricted stock units are issued pursuant to any remuneration policy or other personnel incentive plan that is duly approved by the Issuer's board of directors and (if applicable) its shareholders. Any reference in this Agreement to "**Excluded Instruments**" means all of them.

"**First Tranche Bond Certificate**" means a bond certificate which shall evidence the Initial Subscriber's aggregate holding of First Tranche Bonds in or in substantially the form set out in the First Tranche Bond Instrument including any replacement First Tranche Bond Certificate issued pursuant to the terms of the First Tranche Bond Instrument.

"**First Tranche Bond Documents**" means this Agreement, the First Tranche Bond Instrument (including the First Tranche Conditions), the First Tranche Calculation Agency Agreement, each First Tranche Bond Certificate, such other documents relating to the issuance of the First Tranche Bonds as may be designated in writing by the Parties as being a First Tranche Bond Document.

"**First Tranche Bond Instrument**" has the meaning given to it in Recital (A).

"**First Tranche Bonds**" has the meaning given to it in Recital (A).

"**First Tranche Calculation Agency Agreement**" means the calculation agency agreement relating to the First Tranche Bonds (in the agreed form) to be entered into not later than the First Tranche Closing Date between the Issuer and the Calculation Agent (as supplemented or amended from time to time).

"**First Tranche Closing**" means the consummation of the issue of the First Tranche Bonds to the Initial Subscriber.

"**First Tranche Closing Date**" means, in respect of the First Tranche Bonds, 18 December 2025, or such other date as may be agreed in writing (including by email) between the Parties (each acting in its absolute discretion).

"**First Tranche Conditions**" has the meaning given in Recital (A), and any reference to a particular numbered Condition shall be construed accordingly.

"**First Tranche Register**" means the register of First Tranche Bonds maintained by or on behalf of the Issuer in or substantially in the form set out in the First Tranche Bond Instrument.

"**First Tranche Subscription Fee**" means the subscription commitment fee payable by the Issuer to the Initial Subscriber as consideration for its commitment undertaking under this Agreement, equal to 8.0 per cent. of the principal amount of the First Tranche Bonds.

"**Governmental Authority**" means the government of any nation, or of any political subdivision thereof, whether state, regional or local, and any agency, authority, branch, department, regulatory body, court, central bank or other entity exercising executive, legislative, judicial, taxing, regulatory or administrative powers or functions of or pertaining to government or any subdivision thereof (including any supra-national bodies).

"**IFRS**" means International Financial Reporting Standards issued by the International Accounting Standards Board (IASB) and interpretations issued by the International Reporting Interpretations Committee of the IASB (as amended, supplemented or re-issued from time to time).

"**Indemnified Person**" has the meaning given to it in Clause 5.1(a) (*Indemnity*).

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

"**Initial Subscriber's Solicitors**" means White & Case LLP, a limited liability partnership organised and existing under the laws of England with its registered office at 5 Old Broad Street, London EC2N 1DW, United Kingdom.

"**Intellectual Property Rights**" means, collectively, trademarks, trade names and other rights to inventions, know-how, patents, copyrights, confidential information and other intellectual property.

"**Last Market Capitalisation**" means the market capitalisation of the Issuer based on the Closing Price (as defined in the First Tranche Conditions) of a Share on the dealing day (as defined in the First Tranche Conditions) immediately preceding the Second Tranche Closing Date, as published by or derived from Bloomberg page HP (or any successor page) (setting 'RR902 Current Market Cap', or any other successor setting) (and for the avoidance of doubt as at the date of this Agreement such Bloomberg page for the Shares is NYXH BB Equity HP), as determined by the Calculation Agent, if available or, in any other case, such other source (if any) as shall be agreed in writing (including by email) between the Issuer and the Initial Subscriber (each acting reasonably), and the Market Capitalisation determined as aforesaid on any dealing day shall, if not in EUR, be translated by the Calculation Agent into EUR at the Prevailing Rate (as defined in the First Tranche Conditions) on such dealing day.

"**Licences**" has the meaning given to it in Clause 7.1(q) (*Representations and Warranties*).

"**Material Adverse Change**" means:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) with respect to the Issuer and its Subsidiaries (taken as a whole):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) it is in breach of the terms of, or in default under, any instrument, agreement or order to which it is a party or by which it or its property is bound or an event has occurred which with the giving of notice or lapse of time or other condition would constitute a default under any such instrument, agreement or order, except for any such breach or default which either individually or in the aggregate would not reasonably be expected to be material in the context of the issue and offering of the First Tranche Bonds or the Second Tranche Bonds, as the case may be; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) it is engaged (whether as defendant or otherwise) in, or has knowledge of the existence of, or any threat of, any legal, arbitration, administrative, governmental or other proceedings an adverse result of which would reasonably be expected to be material in the context of the issue and offering of the First Tranche Bonds or the Second Tranche Bonds, as the case may be; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) it has taken any action or any steps have been taken or legal proceedings commenced for the winding up or dissolution of the Issuer or any of its Subsidiaries (other than, in relation to a Subsidiary of the Issuer, as part of a solvent group reorganisation); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) any adverse change or any development or event, in each case when compared to the position which had been publicly disclosed by the Issuer as at the date immediately prior to this Agreement, which would be reasonably expected to, individually or in aggregate, result in a prospective change which is materially adverse to the condition (financial or otherwise), business or general affairs, results of operations, properties or profitability of the Issuer and its Subsidiaries (taken as a whole); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) any development of which the Issuer is, or might reasonably be expected to be, aware that would be reasonably expected to materially adversely affect the ability of the Issuer to

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

consummate the Equity Offering or to perform its respective obligations under the Bond Documents or the Bonds of each Series.

"**Material Adverse Effect**" means (a) any adverse change or any development or event which would be reasonably expected to, individually or in aggregate, result in a prospective change which is materially adverse to the condition (financial or otherwise), business or general affairs, results of operations, properties or profitability of the Issuer and its Subsidiaries (taken as a whole); or (b) any development of which the Issuer is aware that is reasonably likely to materially adversely affect the ability of the Issuer to perform their respective obligations under the Bond Documents or the Bonds of each Series.

"**Money Laundering Laws**" has the meaning given in Clause 7.1(aa) (*Representations and Warranties*).

"**Placing Price**" has the meaning given in Recital (B).

"**Proceedings**" has the meaning given in Clause 21.2 (*Jurisdiction*).

"**Prohibited Payment**" has the meaning given in Clause 7.1(z)(ii) (*Representations and Warranties*).

"**Public Statements**" means any information released to the public by or on behalf of the Issuer or any of its Subsidiaries, whether such information was required to be made public by applicable law and regulation (including, but not limited to, Regulation 596/2014/EU and all disclosures required by the Stock Exchanges or under Belgian or United States laws and regulations) or otherwise, on or after 31 December 2024, as amended or supplemented from time to time.

"**Regulation S**" means Regulation S under the Securities Act.

"**Related Parties**" has the meaning given to it in Clause 5.1(b) (*Indemnity*).

"**Restricted Information**" means any information that is or may be material non-public and price-sensitive or is insider information within the meaning of applicable insider dealing or market abuse law (including Regulation 596/2014/EU).

"**Sanctions**" means any sanctions administered by the Office of Foreign Assets Control of the U.S. Department of Treasury, the U.S. State Department, any other agency of the U.S. government, the United Nations, the European Union or the United Kingdom.

"**Second Tranche Bond Certificate**" means a bond certificate which shall evidence the Initial Subscriber's aggregate holding of Second Tranche Bonds in or in substantially the form set out in the Second Tranche Bond Instrument including any replacement Second Tranche Bond Certificate issued pursuant to the terms of the Second Tranche Bond Instrument.

"**Second Tranche Bond Documents**" means this Agreement, the Second Tranche Bond Instrument (including the Second Tranche Conditions), the Second Tranche Calculation Agency Agreement, each Second Tranche Bond Certificate, such other documents relating to the issuance of the Second Tranche Bonds as may be designated in writing by the Parties as being a Second Tranche Bond Document.

"**Second Tranche Bond Instrument**" means the bond instrument (including the Second Tranche Conditions) constituting the Second Tranche Bonds to be entered into by the Issuer not later than the Second Tranche Closing Date (as supplemented or amended from time to time).

"**Second Tranche Bonds**" has the meaning given to it in Recital (A).

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

"**Second Tranche Calculation Agency Agreement**" means the calculation agency agreement relating to the Second Tranche Bonds to be entered into not later than the Second Tranche Closing Date between the Issuer and the Calculation Agent (as supplemented or amended from time to time).

"**Second Tranche Closing**" means the completion of the issue of the Second Tranche Bonds to the Initial Subscriber.

"**Second Tranche Closing Date**" means such date as specified in the Second Tranche Request Notice (or as otherwise may be agreed in writing (including by email) between the Parties (each acting in its absolute discretion)), and if such day is not a Business Day, the next following Business Day.

"**Second Tranche Conditions**" means the terms and conditions of the Second Tranche Bonds which shall be set out in the Second Tranche Bond Instrument, and any reference to a particular numbered Condition shall be construed accordingly.

"**Second Tranche Register**" means the register of Second Tranche Bonds to be maintained by or on behalf of the Issuer in or substantially in the form that shall be set out in the Second Tranche Bond Instrument.

"**Second Tranche Request Notice**" means a request notice in or substantially in the form set out in Schedule 3 (*Form of Second Tranche Request Notice*).

"**Second Tranche Subscription Fee**" means the subscription commitment fee payable by the Issuer to the Initial Subscriber as consideration for its commitment undertaking under this Agreement, equal to 8.0 per cent. of the principal amount of the Second Tranche Bonds.

"**Securities Act**" means the United States Securities Act of 1933, as amended.

"**Series**" has the meaning given to it in Recital (A).

"**Share Settlement Option**" has the meaning given to it in the First Tranche Conditions or the Second Tranche Conditions, as the context may require.

"**Shares**" has the meaning given to it in Recital (B).

"**Stock Exchanges**" means The Nasdaq Global Market and Euronext Brussels, and "**Stock Exchange**" means any one of them.

"**Subscription Price**" means 100.0 per cent. of the principal amount of each of the First Tranche Bonds or Second Tranche Bonds, as the case may be, to be subscribed by the Initial Subscriber upon the terms and subject to the conditions set out in this Agreement.

"**Subsidiary**" means, in relation to any Person (the "**first Person**") at any particular time, any other Person (the "**second Person**") (i) whose affairs and policies the first Person controls or has the power to control, whether by ownership of share capital, contract, the power to appoint or remove members of the governing body of the second person or otherwise or (ii) whose assets, liabilities, equity, income, expenses and cash flows are, in accordance with applicable law and the International Standards on Auditing issued by the International Federation of Accountants (as amended, supplemented or re-issued from time to time), consolidated with those of the first Person in the consolidated financial statements of such Person.

"**Term Sheet**" means the term sheet dated 5 November 2025 in respect of the Bonds of each Series between Heights Capital Management, Inc. and the Issuer.

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**Transaction Press Release**" has the meaning given in Clause 9(h) (*Undertakings by the Issuer*).

"**U.S.$**" means United States Dollars, the lawful currency of the United States of America.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**1.2** **Interpretation** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Unless a contrary indication appears, any reference in this Agreement to:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the "**Initial Subscriber**" or any "**Party**" shall be construed so as to include its successors in title or assignees;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) "**assets**" includes present and future properties, revenues and rights of every description;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) a "**Bond Document**" or any other agreement or instrument is a reference to that Bond Document or other agreement or instrument as amended, novated, supplemented, extended or restated;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) a "**person**" includes any individual, firm, company, corporation, government, state or agency of a state or any association, trust, joint venture, consortium, partnership or other entity (whether or not having separate legal personality);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) a "**regulation**" includes any regulation, rule, official directive, or official guidance of any governmental, intergovernmental or supranational body, agency, department or of any regulatory, self-regulatory or other Governmental Authority; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) a provision of law is a reference to that provision as amended or re-enacted from time to time.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Time shall be of the essence in this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Headings and the table of contents are for ease of reference only and shall not affect the construction of this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) Any reference in this Agreement to a Clause or a Schedule is, unless otherwise stated, to a Clause or a Schedule hereof. The Schedules form an integral part of this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) Any reference in this Agreement to a document being in "agreed form" means that the document in question has been agreed between the Parties as of the date of this Agreement, subject to any amendments that the Parties may agree in writing prior to their entry into such documents.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) Belgian terms

Insofar as it applies to the Issuer, a reference in this Agreement to:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) "**gross negligence**" is a reference to *zware fout/faute lourde* and "**wilful misconduct**" is a reference to *opzet/intention*;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) a "**liquidator** ", "**compulsory manager** ", "**receiver** ", "**administrative receiver** ", "**administrator**" or other similar officer includes any *insolventiefunctionaris* / *praticien de l'insolvabilité*, *curator/curateur*, *vereffenaar/liquidateur*, *gerechtsmandataris/mandataire de justice*, *voorlopig bewindvoerder/administrateur provisoire*, *gerechtelijk bewindvoerder/administrateur judiciaire*, *mandataris ad hoc/mandataire ad hoc*,

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*vereffeningsdeskundige/praticien de la liquidation and herstructureringsdeskundige/praticien de la réorganisation,* as applicable;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) a "**reorganisation**" includes any *gerechtelijke reorganisatie/réorganisation judiciaire, procedure van minnelijk akkoord buiten gerechtelijke reorganisatie/ procédure d'accord amiable hors réorganisation judiciaire* and any *akkoord voor de kamer voor ondernemingen in moeilijkheden/accord devant la chambre des entreprises en difficulté*;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) "**security**" or "**security interest**" includes a mortgage (*hypotheek/hypothèque*), a pledge (*pand/nantissement*), a transfer by way of security (*overdracht ten titel van zekerheid/transfert à titre de garantie*), any other proprietary security interest (*zakelijke zekerheid/sûreté réelle*), a privilege (*voorrecht/privilège*), a reservation of title arrangement (*eigendomsvoorbehoud/réserve de propriété*), any retention right (*retentierecht/droit de rétention)* and a promise or mandate to grant a mortgage or any other proprietary security interest;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) a person being "**incorporated**" in Belgium or of which its "**jurisdiction of incorporation**" is Belgium, means that that person has its statutory seat (*statutaire zetel/siège statutaire*) in Belgium;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) a "**composition** ", "**compromise** ", "**assignment**" or "**arrangement**" includes a *gerechtelijk of buitengerechtelijk minnelijk akkoord met schuldeisers* / *accord amiable judiciaire ou extrajudiciaire avec des créanciers*, any *gerechtelijke reorganisatie/réorganisation judiciaire* or any *procedure van overdracht onder gerechtelijk gezag/ procédure de transfert sous autorité judiciaire*, as applicable;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) "**winding up** ", "**administration**" or "**dissolution**" includes any *vereffening/liquidation*, *ontbinding/dissolution*, *besloten voorbereiding van het faillissement/préparation privée d'une faillite, faillissement/faillite* and *procedure van overdracht onder gerechtelijk gezag/ procédure de transfert sous autorité judiciaire:* 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(viii) "**insolvency**" includes any *insolventieprocedure* / *procédure d'insolvabilité*, *gerechtelijke reorganisatie* / *réorganisation judiciaire*, *faillissement* / *faillite,* and any *deficitaire vereffening/liquidation déficitaire*;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ix) a "**de-merger**" or "**merger**" includes a *splitsing/scission* and a *fusie/fusion* as well as assimilated transactions (*gelijkgestelde verrichtingen/operations assimilées*) in accordance with the Belgian Code of Companies and Associations; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(x) "**share capital**" refers to the share capital of the relevant company or, in relation to any company form without share capital, the own funds of the relevant company.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**1.3** **Contracts (Rights of Third Parties) Act 1999** 

Except in respect of the rights conferred on Indemnified Persons in Clause 5 (*Indemnification of the Initial Subscriber*), a person who is not a Party to this Agreement has no right under the Contracts (Rights of Third Parties) Act 1999 to enforce any term of this Agreement, but this does not affect any right or remedy of a third party which exists or is available apart from that Act.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**2.** **Issue and Subscription of the First Tranche Bonds** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**2.1** **Undertaking to Issue the First Tranche Bonds** 

With effect from the date of this Agreement, the Issuer undertakes to the Initial Subscriber that, subject to and in accordance with the terms and conditions of this Agreement, the Issuer will on the First Tranche Closing Date:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) issue the First Tranche Bonds to the Initial Subscriber in the principal amount of €22,500,000; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) execute the First Tranche Bond Instrument, the First Tranche Calculation Agency Agreement, the First Tranche Bond Certificate in respect of the Initial Subscriber and such other documents necessary for the issuance of the First Tranche Bonds and the consummation of the transaction contemplated by this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**2.2** **Undertaking to Subscribe for the First Tranche Bonds** 

With effect from the date of this Agreement, and subject to the satisfaction of the conditions precedent set out in Clause 3.1(a) (*Conditions Precedent to First Tranche Closing*), the Initial Subscriber undertakes to the Issuer that, subject to and in accordance with the terms and conditions of this Agreement, it will subscribe for the First Tranche Bonds in the principal amount of €22,500,000 on the First Tranche Closing Date at the Subscription Price (less any Agreed Expenses and the First Tranche Subscription Fee).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**2.3** **First Tranche Subscription Fee** 

On the First Tranche Closing Date, the Issuer shall pay to the Initial Subscriber the First Tranche Subscription Fee, which shall be set-off against the Subscription Price.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**2.4** **Initial Conversion Price (First Tranche Bonds)** 

Each of the Issuer and the Initial Subscriber hereby acknowledge and agree that the initial Conversion Price (as defined in the First Tranche Conditions, and rounded down (if necessary) to the nearest whole multiple of €0.0001) shall be equal to 125 per cent. of the lower of: (a) Placing Price of the Shares being issued pursuant to the Equity Offering, as was publicly announced by the Issuer in connection therewith; and (b) the Reference Lowest Daily Market Price (as defined in the First Tranche Conditions, and rounded down (if necessary) to the nearest whole multiple of €0.0001) (it being understood the SSO Reference Date shall for these purposes be the dealing day (as defined in the First Tranche Conditions) immediately preceding the First Tranche Closing Date).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**3.** **Completion and Settlement** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**3.1** **Conditions Precedent to First Tranche Closing** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) The Initial Subscriber will only be obliged to subscribe for the First Tranche Bonds if:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) prior to the First Tranche Closing, the Initial Subscriber has received all of the documents listed in Schedule 1 (*First Tranche Conditions Precedent*) in form and substance reasonably satisfactory to it (in its absolute discretion), save for the documents listed in Clause 3.2(a)(ii) (*First Tranche Closing Procedure*);

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) on each of the date hereof and on the First Tranche Closing Date: (A) the representations and warranties of the Issuer in this Agreement are true, accurate and correct at, and as if made on, such date, (B) the Issuer has performed all of its obligations under this Agreement to be performed on or before such date and on the First Tranche Closing Date, and (C) there has been no material breach of any of the obligations of the Issuer under this Agreement;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) on the First Tranche Closing Date, no Default is continuing or would result from the issue of the First Tranche Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) there has been no Material Adverse Change;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) in the Initial Subscriber's opinion (acting in good faith), since the date of this Agreement there has been no adverse change in the financial markets in the United States, the Cayman Islands, Belgium, the European Economic Area or the international financial markets, any outbreak of hostilities or escalation thereof, any act of terrorism or war or any declaration of emergency or martial law or other calamity or crisis (including without limitation, a material escalation in any pandemic on or after the date of this Agreement) nor any change or development involving a prospective change in national or international political, financial or economic conditions, currency exchange rates or exchange controls, whether or not foreseeable at the date of this Agreement, which would reasonably be considered material in the context of the issue of the First Tranche Bonds and the purchase thereof by the Initial Subscriber;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) on or prior to the First Tranche Closing, the Initial Subscriber's Solicitors have received the documents listed in Clause 3.2(a)(ii) (*First Tranche Closing Procedure*) to be held in escrow pending the First Tranche Closing;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) on or prior to the First Tranche Closing Date, and save for any Shares issued in connection with the Equity Offering or any Excluded Instrument, there are no issuances of and no grants of rights in respect of, or sales or subscriptions of, nor has the Issuer entered into any agreement, contract, instrument or other document in respect of, any of the following: (A) the Shares; (B) ordinary shares in any other series in the ordinary shares of the Issuer; or (C) Securities (as defined in the First Tranche Conditions) which by their terms carry (directly or indirectly) rights of conversion into, or exchange or subscription for, or the right to otherwise acquire, any Shares or any other shares in the capital of the Issuer;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(viii) the First Tranche Closing Date occurs on or prior to 23 December 2025 (or such other date as may be agreed in writing (including by email) the Parties (each acting in its absolute discretion)), and if such day is not a Business Day, the next following Business Day; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ix) on or prior to the First Tranche Closing Date:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) the Equity Offering is announced, priced and consummated with the gross proceeds being no less than €20,000,000; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) the Shares being issued pursuant to the Equity Offering are validly admitted to trading on a Stock Exchange.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) The Initial Subscriber shall notify the Issuer promptly upon receipt by or on behalf of the Initial Subscriber of all of the documents and other evidence listed in Schedule 1 (*First Tranche Conditions Precedent*) in form and substance reasonably satisfactory to it.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) The Initial Subscriber may, in its absolute discretion and upon such terms as it thinks fit, waive compliance with the whole or any part of this Clause 3.1.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) If, on the First Tranche Closing Date, any of the conditions precedent provided in Clause 3.1 have not been satisfied, nor waived as provided in Clause 3.1(c) above, then the Initial Subscriber shall, at its election, be relieved of all its obligations under Clause 2.2 (*Undertaking to Subscribe for the First Tranche*) to subscribe for the First Tranche Bonds under this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) An election by the Initial Subscriber under Clause 3.1(d) above shall not operate as a waiver of any rights the Initial Subscriber may have by reason of such failure to satisfy or such non-fulfilment.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**3.2** **First Tranche Closing Procedure** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Following the notification to the Issuer referred to in Clause 3.1(b) (*Conditions Precedent to First Tranche Closing*), and by no later than the First Tranche Closing Date:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the Issuer shall make (or shall procure the making of) the appropriate entries in the First Tranche Register showing the Initial Subscriber as the registered owner of €22,500,000 in principal amount of First Tranche Bonds; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the Issuer shall issue and deliver to the Initial Subscriber's Solicitors:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) the initial First Tranche Bond Certificate dated the First Tranche Closing Date in respect of the First Tranche Bonds; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) a certified excerpt of the First Tranche Register reflecting the entries referred to in Clause 3.2(a)(i) above,

such documents to be held in escrow to the Issuer's order until such time as they are deemed to be released pursuant to Clause 3.2(d) below.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) At the First Tranche Closing, and following confirmation of receipt from the Initial Subscriber's Solicitors of the documents specified in Clause 3.2(a)(ii) above, the Initial Subscriber shall pay or procure the payment of its subscription monies (net of the First Tranche Subscription Fee and any Agreed Expenses) in immediately available funds to the following account:

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| | |
|:---|:---|
| Account Holder: | [\*\*\*] |
| Account number: | [\*\*\*] |
| Bank: | [\*\*\*] |
| Swift/Bic | [\*\*\*] |

---

or such other account of the Issuer as the Issuer designates to the Initial Subscriber in writing at least five Business Days prior to the First Tranche Closing Date.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) The Initial Subscriber shall promptly notify the Issuer that it has effected the payment specified in Clause 3.2(b) above and provide evidence or a receipt of such payment transfer.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) Upon receipt of the net subscription monies specified in Clause 3.2(b) above, the documents referred to in Clause 3.2(a)(ii) above shall be deemed to be automatically released by the Issuer to or to the order of the Initial Subscriber.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) The Issuer shall promptly on the First Tranche Closing Date furnish a written confirmation to the Initial Subscriber of its receipt of the relevant subscription monies.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**4.** **Issue and Subscription of the Second Tranche Bonds** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**4.1** **Second Tranche Request Notice** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) During the period commencing from (and including) the date falling seven months following the First Tranche Closing Date to (but excluding) the date falling one month thereafter, the Issuer may (on one occasion only) request the subscription by the Initial Subscriber of Second Tranche Bonds in a principal amount of €22,500,000 (unless a lesser amount is agreed in writing (including by email) between the Parties) by delivering a Second Tranche Request Notice to the Initial Subscriber (which may be delivered by email and in accordance with Clause 10 (*Notices*)) not later than five Business Days prior to the Second Tranche Closing Date (or such date as may be agreed in writing (including by email) between the Parties). Any Second Tranche Request Notice shall be irrevocable once delivered.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) The Issuer acknowledges that the Second Tranche Request Notice may contain Restricted Information. The Issuer shall (in consultation with the Initial Subscriber) do whatever is necessary to ensure that any such Restricted Information is publicly disclosed to the market in accordance with applicable laws, regulations or rules (including, for the avoidance of doubt, by way of announcement through a Regulatory Information Service and Form 6-K (or similar)) or as otherwise may be effective so as to ensure that, on the same date of delivery of a Second Tranche Request Notice in accordance with paragraph (a) above, the Initial Subscriber is no longer in possession of Restricted Information and is no longer restricted from trading in any securities or instruments of the Issuer or any of its Subsidiaries or any other person by reason of the receipt of that Restricted Information.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**4.2** **Undertaking to Issue the Second Tranche Bonds** 

Subject to and in accordance with the terms and conditions of this Agreement, the Issuer will on the Second Tranche Closing Date:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) issue the Second Tranche Bonds to the Initial Subscriber in the principal amount of €22,500,000 (subject to Clause 4.1(a) (*Second Tranche Request Notice*)); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) execute the Second Tranche Bond Instrument, the Second Tranche Calculation Agency Agreement, the Second Tranche Bond Certificate in respect of the Initial Subscriber and such other documents necessary for the issuance of the Second Tranche Bonds and the consummation of the transaction contemplated by this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**4.3** **Undertaking to Subscribe for the Second Tranche Bonds** 

Subject to the satisfaction of the conditions precedent set out in Clause 4.4 (*Terms of the Second Tranche Bonds*) and Clause 4.6 (*Conditions Precedent to Second Tranche Closing*), the Initial Subscriber undertakes to the Issuer that, subject to and in accordance with the terms and conditions of this Agreement, it will subscribe for the Second Tranche Bonds in the principal amount of €22,500,000 (subject to Clause 4.1(a) (*Second Tranche Request Notice*)) on the Second Tranche

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Closing Date at the Subscription Price (less the Second Tranche Subscription Fee and any costs and expenses (including legal expenses) properly incurred by the Initial Subscriber in connection therewith).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**4.4** **Second Tranche Subscription Fee** 

On the Second Tranche Closing Date, the Issuer shall pay to the Initial Subscriber the Second Tranche Subscription Fee, which shall be set-off against the Subscription Price.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**4.5** **Terms of the Second Tranche Bonds** 

Each of the Issuer and the Initial Subscriber hereby agree that the terms of the Second Tranche Bonds and the Second Tranche Bond Documents shall be substantially in the form of the terms of the First Tranche Bonds and the First Tranche Bond Documents, except that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the maturity date of the Second Tranche Bonds shall be the date falling on the third anniversary of the Second Tranche Closing Date;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the initial conversion price of the Second Tranche Bonds shall be equal to 125 per cent. of the EUR price per Share (rounded down (if necessary) to the nearest whole multiple of €0.0001) that is equal to the lowest of the five Volume Weighted Average Prices (as defined in the First Tranche Conditions) of a Share on Euronext Brussels on each of the five consecutive dealing days (as defined in the First Tranche Conditions) ending on (but excluding) the Second Tranche Closing Date;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) the first payment date for principal and interest under the Second Tranche Bond shall occur on the date falling on:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) if the next Scheduled Amortisation Payment Date and Interest Payment Date shall occur more than one calendar month after the Second Tranche Closing Date, that next upcoming Scheduled Amortisation Payment Date and Interest Payment Date (each as defined in the First Tranche Conditions) under the First Tranche Bonds; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) if the next Scheduled Amortisation Payment Date and Interest Payment Date shall occur less than or on the date falling one calendar month after the Second Tranche Closing Date, the subsequent Scheduled Amortisation Payment Date and Interest Payment Date after the occurrence of such foregoing payment date; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) such other terms as may be mutually agreed between the Parties in writing.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**4.6** **Conditions Precedent to Second Tranche Closing** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) The Initial Subscriber will only be obliged to subscribe for the Second Tranche Bonds if:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) prior to the Second Tranche Closing, the Initial Subscriber has received all of the documents listed in Schedule 2 (*Second Tranche Conditions Precedent*) in form and substance reasonably satisfactory to it (in its absolute discretion), save for the documents listed in Clause 3.2(a)(ii) (*First Tranche Closing Procedure*) (which shall be construed in accordance with Clause 4.7 (*Second Tranche Closing Procedure*));

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) on the Second Tranche Closing Date: (A) the representations and warranties of the Issuer in this Agreement are true, accurate and correct at, and as if made on, such date, (B) the Issuer has in all material respects performed all of its respective

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obligations under this Agreement to be performed on or before such date and on the Second Tranche Closing Date, and (C) there has been no material breach of any of the obligations of the Issuer under this Agreement;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) on the Second Tranche Closing Date, no Default is continuing or would result from the issue of the Second Tranche Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) there has been no Material Adverse Change;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) in the Initial Subscriber's opinion (acting in good faith), since the date of this Agreement there has been no adverse change in the financial markets in the United States, the Cayman Islands, Belgium, the European Economic Area or the international financial markets, any outbreak of hostilities or escalation thereof, any act of terrorism or war or any declaration of emergency or martial law or other calamity or crisis (including without limitation, a material escalation in any pandemic on or after the date of this Agreement) nor any change or development involving a prospective change in national or international political, financial or economic conditions, currency exchange rates or exchange controls, whether or not foreseeable at the date of this Agreement, which would reasonably be considered material in the context of the issue of the Second Tranche Bonds and the purchase thereof by the Initial Subscriber;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) between the date of the Second Tranche Request Notice and the Second Tranche Closing (inclusive), the Initial Subscriber's Solicitors have received the documents listed in Clause 3.2(a)(ii) (*First Tranche Closing Procedure*) (which shall be construed in accordance with Clause 4.7 (*Second Tranche Closing Procedure*)) to be held in escrow pending Second Tranche Closing;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) between the date of the Second Tranche Request Notice and the Second Tranche Closing Date (inclusive), and save for any Shares to be issued in connection with any Excluded Instrument or the First Tranche Bonds, there are no issuances of and no grants of rights in respect of, or sales or subscriptions of, nor has the Issuer entered into any agreement, contract, instrument or other document in respect of, any of the following: (A) the Shares; (B) ordinary shares in any other series in the ordinary shares of the Issuer; or (C) Securities (as defined in the Second Tranche Conditions) which by their terms carry (directly or indirectly) rights of conversion into, or exchange or subscription for, or the right to otherwise acquire, any Shares or any other shares in the capital of the Issuer;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(viii) the Second Tranche Closing Date occurs on or prior to the date falling 22 calendar days after the date of the Second Tranche Request Notice (or such other date as may be agreed in writing (including by email) the Parties (each acting in its absolute discretion)), and if such day is not a Business Day, the next following Business Day;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ix) the arithmetic mean (rounded to the nearest whole multiple of U.S.$1.00 (with U.S.$0.50 being rounded upwards)) of the Daily Traded Values (determined in accordance with limb (i) of the definition thereof in the First Tranche Conditions, but for this purpose (A) disregarding the words "(for the purposes of determining any Share Average DTV)" and (B) assuming the reference to "EUR" to be a reference to "U.S.$") of the Shares on each Qualifying Stock Exchange Day comprised in the period of 60 consecutive Qualifying Stock Exchange Days (as defined in the First Tranche Conditions) ending on the Qualifying Stock Exchange

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Day immediately preceding the date of the Second Tranche Request Notice is greater than U.S.$1,000,000 (or its equivalent in any other currency), all as determined by the Calculation Agent; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(x) the Issuer has a Last Market Capitalisation and an Average Market Capitalisation that are each greater than €240,000,000, as determined by the Calculation Agent.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) The Initial Subscriber shall notify the Issuer promptly upon receipt by or on behalf of the Initial Subscriber of all of the documents and other evidence listed in 2 (*Second Tranche Conditions Precedent*) in form and substance satisfactory to it.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) The Initial Subscriber may, in its absolute discretion and upon such terms as it thinks fit, waive compliance with the whole or any part of this Clause 4.6.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) If, on the Second Tranche Closing Date, any of the conditions precedent provided in Clause 4.6(a) above have not been satisfied, nor waived as provided in Clause 4.6(c) above, then the Initial Subscriber shall, at its election, be relieved of all its obligations under Clause 4.3 (*Undertaking to Subscribe for the Second Tranche Bonds*) to subscribe for the Second Tranche Bonds under this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) An election by the Initial Subscriber under Clause 4.6(d) above shall not operate as a waiver of any rights the Initial Subscriber may have by reason of such failure to satisfy or such non-fulfilment.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**4.7** **Second Tranche Closing Procedure** 

The closing procedure set out in Clause 3.2 (*First Tranche Closing Procedure*) shall apply to the Second Tranche Bonds Closing, except that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) any reference to the First Tranche Bonds shall be construed to refer to the Second Tranche Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) any reference to the First Tranche Closing Date or First Tranche Closing shall be construed to refer to the Second Tranche Closing Date or Second Tranche Closing, respectively;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) any reference to the First Tranche Register or the First Tranche Bond Certificate shall be construed to refer to the Second Tranche Register or the Second Tranche Bond Certificate, respectively;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) Clause 3.2(a)(i) (*First Tranche Closing Procedure*) shall be deemed to be modified to read:

"the Issuer shall make (or shall procure the making of) the appropriate entries in the Second Tranche Register showing the Initial Subscriber as the registered owner of €22,500,000 in principal amount of Second Tranche Bonds"; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) the reference to "(net of the First Tranche Subscription Fee and any Agreed Expenses)" in Clause 3.2(b) (*First Tranche Closing Procedure*) shall be modified to read "(less the Second Tranche Subscription Fee and any costs and expenses (including legal expenses) properly incurred by the Initial Subscriber in connection with the issue of the Second Tranche Bonds)".

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**5.** **Indemnification of the Initial Subscriber** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**5.1** **Indemnity** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) The Issuer agrees to indemnify and hold harmless the Initial Subscriber and each of its affiliates and all their respective officers, directors, general partners, employees, Heights Capital Management, Inc., Heights Capital Ireland, LLC, their respective shareholders, affiliates and representatives and each of their respective successors (but, for the avoidance of doubt, not including any permitted transferee or assignee of the Initial Subscriber) (each, an "**Indemnified Person**") from and against any and all actions, suits, investigation, inquiry, claims, losses, damages, liabilities, proceedings and documented related and properly incurred out-of-pocket fees and expenses of any kind or nature (a "**Loss**") (subject to the limitations set forth in this Clause 5) which may be incurred by any such Indemnified Person as a result of or arising out of or in connection with or based on:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) *Misrepresentation*: any breach or alleged breach of the representations and warranties contained in, or made or deemed to be made by the Issuer under, this Agreement by reference to the facts and circumstances then subsisting; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) *Breach*: any breach or alleged breach by the Issuer of any of its obligations in any Bond Document or the Bonds of any Series (including, without limitation, the failure by the Issuer to issue the First Tranche Bonds on the First Tranche Closing Date or the Second Tranche Bonds on the Second Tranche Closing Date, as the case may be); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) *Announcements*: any untrue statement contained in any announcement or press release published following the date hereof by or on behalf of the Issuer or any of its Subsidiaries or their respective affiliates in connection with the First Tranche Bonds or the Second Tranche Bonds, or any omission or alleged omission of a material fact required to be stated therein or necessary to make the statements therein, in light of the circumstances in which they are made, not misleading.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) The Issuer shall pay to the relevant Indemnified Person within 10 Business Days of written demand therefor an amount equal to such Loss; *provided, however*, *that* no Indemnified Person will be entitled to indemnity hereunder in respect of any Loss to the extent that it is finally judicially determined by a court of competent jurisdiction that such Loss resulted from the negligence, bad faith or wilful misconduct of such Indemnified Person or its affiliates, officers, directors, partners, trustees, employees, shareholders, agents or controlling persons (all such persons "**Related Parties** ").

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) This Agreement shall not cause to the Initial Subscriber to have any duty or obligation, whether as fiduciary or trustee for any Indemnified Person or Related Party or otherwise, to recover any such payment or to account to any other person for any amounts paid to it under this Clause 5.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**5.2** **Conduct of Claims** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) In case any action or claim shall be brought against any Indemnified Person in respect of which recovery may be sought from the Issuer under this Clause 5, the relevant Indemnified Person shall promptly notify the Issuer in writing of such fact, but failure to do so will not relieve the Issuer from any liability under this Agreement and in any event shall not relieve it from any liability which it may have otherwise than on account of the indemnities contained in this Agreement except, in the case of an unreasonable delay to

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notify the Issuer by such Indemnified Person, to the extent that such delay actually and materially prejudices the Issuer.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Each Indemnified Person shall thereafter, subject to any requirement imposed by an insurer of the Indemnified Person and to the extent permitted by applicable law or regulation:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) at reasonable intervals keep the Issuer informed of the progress of the claim or action;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) provide the Issuer with copies of such documentation relating to the claim or action as the Indemnified Person may reasonably request; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) maintain reasonable consultation with the Issuer regarding decisions concerning the claim or action,

subject in each case to the Indemnified Person being indemnified and secured to its reasonable satisfaction against all Losses incurred by it in consequence of its compliance with this Clause 5, and provided that nothing in this Clause 5 shall:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) require any Indemnified Person to provide the Issuer with a copy of any part of any document which it, in good faith, considers to be held by it subject to a duty of confidentiality or to be privileged whether in the context of any litigation connected with the claim or otherwise; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) require an Indemnified Person to do, or refrain from doing, anything which would, or which the Issuer considers might, either prejudice any insurance cover to which it or any other Indemnified Person may from time to time be entitled, or from which it or any of them may benefit or which may prejudice the reputation or standing of such Indemnified Person or of any other Indemnified Person.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) The Issuer may participate at its own expense in the defence of any such action; *provided, however, that* legal advisers to the Issuer shall not (except with the consent of the relevant Indemnified Person (such consent not to be unreasonably withheld, conditioned or delayed)) also be legal advisers to the Indemnified Person.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) The Issuer shall not, without the prior written consent of the relevant Indemnified Person (such consent not to be unreasonably withheld, conditioned or delayed), settle or compromise or consent to the entry of any judgment with respect to any litigation, or any investigation or proceeding by any governmental agency or body, commenced or threatened, or any claim whatsoever in respect of which indemnification could be sought under this Clause 5 (whether or not the Indemnified Person(s) are actual or potential parties thereto), unless such settlement, compromise or consent:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) includes an unconditional release of each Indemnified Person from all liability arising out of such litigation, investigation, proceeding or claim; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) does not include a statement as to or an admission of fault, culpability or a failure to act by or on behalf of any Indemnified Person.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**5.3** **Currency Indemnity** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) If any sum due from the Issuer under this Agreement (a "**Sum** "), or any order, judgment or award given or made in relation to a Sum, has to be converted from the currency (the

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"**First Currency**") in which that Sum is payable into another currency (the "**Second Currency**") for the purpose of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) making or filing a claim or proof against the Issuer; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) obtaining or enforcing an order, judgment or award in relation to any litigation or arbitration proceedings,

the Issuer shall as an independent obligation, within five Business Days of demand, indemnify the Initial Subscriber to whom that Sum is due against any cost, loss or liability arising out of or as a result of the conversion, including any discrepancy between (A) the rate of exchange used to convert that Sum from the First Currency into the Second Currency and (B) the rate or rates of exchange available to that person at the time of its receipt of that Sum.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) The Issuer waives any right it may have in any jurisdiction to pay any amount under this Agreement in a currency or currency unit other than that in which it is expressed to be payable.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**5.4** **Other Indemnities** 

The Issuer shall, within five Business Days of demand, indemnify the Initial Subscriber against any cost, loss or liability properly incurred by the Initial Subscriber (acting reasonably) as a result of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) investigating any event which it reasonably believes is a breach of the terms of this Agreement; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) acting or relying on any notice, request or instruction which it reasonably believes to be genuine, correct and appropriately authorised.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**6.** **Costs and Expenses** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**6.1** **Transaction Expenses** 

With effect from the date of this Agreement:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the Issuer shall be responsible for its own expenses and the fees and expenses of all third parties (including the Calculation Agent) appointed under or in connection with the Bonds of each Series, in connection with the preparation and execution of the Bond Documents and the issue and performance of the Bonds of each Series;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the Issuer shall be responsible for any costs and expenses (including legal fees) properly incurred by the Initial Subscriber in connection with the preparation and execution of the First Tranche Bond Documents and the consummation of the issuance of the First Tranche Bonds, *provided that* the amount payable by the Issuer under this paragraph shall not exceed an amount equal to [\*\*\*] (or its equivalent in any other currency) (it being agreed that such limitation is without prejudice to any value added or similar tax payable thereon, which shall be borne by the Issuer). The Initial Subscriber shall be responsible for any costs and expenses so incurred by it in excess of such limitation;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) the Issuer shall be responsible for any reasonable costs and expenses (including legal fees) properly incurred by the Initial Subscriber in connection with the preparation, negotiation or execution of any documents or instruments with the European Investment Bank in the context of the transactions envisaged by this Agreement; and

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) the Issuer shall be responsible for any reasonable costs and expenses (including legal fees) properly incurred by the Initial Subscriber in connection with the preparation and execution of the Second Tranche Bond Documents and the consummation of the issuance of the Second Tranche Bonds.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**6.2** **Amendment Costs** 

If the Issuer requests an amendment, waiver or consent in respect of any of the Bond Documents and such requests for amendments, waivers or consents require legal fees to be incurred, the Issuer shall, within five Business Days of demand, reimburse the Initial Subscriber for the reasonable amount of such legal costs and expenses properly incurred by it in responding to, evaluating, negotiating or complying with that request or requirement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**6.3** **Ongoing Costs** 

The Issuer shall, within five Business Days of demand, reimburse the Initial Subscriber for any reasonable costs and expenses incurred by the Initial Subscriber from time to time in connection with (a) its compliance with any terms of the Bond Documents applicable to it, and (b) its compliance with any applicable reporting obligations that it becomes subject to in connection with the execution or performance of any of the Bond Documents, including it becoming the beneficial owner of (and any subsequent disposal of) any Shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**6.4** **Enforcement Costs** 

The Issuer shall, within five Business Days of demand, pay to the Initial Subscriber the amount of all reasonable costs and expenses (including legal fees) incurred by the Initial Subscriber in connection with the enforcement of, or the preservation of any rights under, the Bonds of any Series and the Bond Documents.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**7.** **Representations and Warranties of the Issuer** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**7.1** **Representations and Warranties** 

The Issuer makes the representations and warranties set out below in this Clause 7.1 to the Initial Subscriber in respect of the First Tranche Bonds on the date of this Agreement, on the First Tranche Closing Date and on each intervening day:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) That:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) no Public Statement (save as modified, supplemented or superseded by any other Public Statement) contained an untrue statement of a material fact or omitted to state a material fact necessary to make the statements therein, in light of the circumstances under which they were made, not misleading;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) all expressions of opinion, forecasts or estimates of the Issuer contained in any such Public Statements were made in good faith on reasonable grounds after due and careful consideration and all such forecasts, estimates and expressions of opinion, intention or expectation remain truly and honestly held;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) other than in respect of the matters which are the subject of this Agreement and the Equity Offering, none of the Issuer nor any of its directors or officers are, after due and careful consideration, aware of any non-public fact, circumstance or information that:

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) constitutes Restricted Information with respect to the Bonds of either Series, the Shares, the Issuer or any of its Subsidiaries, or would reasonably be expected to become, required or obliged to publish or otherwise make available to the public pursuant to applicable laws and regulations (including under applicable listing requirements), whether to correct a misleading impression or otherwise to avoid behaviour which would constitute market abuse (in contravention of Regulation 596/2014/EU or any other applicable insider dealing or market abuse law) which has not been published;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) relates to any actual, ongoing or pending claim, dispute, investigation or proceeding initiated by or otherwise involving Inspire Medical or its Subsidiaries or its affiliates and, to the best of the Issuer's knowledge, no claim, dispute, investigation or proceedings are threatened or contemplated by Inspire Medical against the Issuer, its Subsidiaries or its affiliates; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(C) is currently, or would reasonably be expected to become, the subject of any application or request to delay disclosure or otherwise extend any deadline for mandatory disclosure under applicable law; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(D) if made public, would be likely to have a significant effect upon the market price of the Shares, and in respect of which the Issuer has delayed disclosure in compliance with applicable law; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) the Issuer is in compliance with the rules for companies published by each Stock Exchange (including, but not limited to, continuing disclosure obligations) and all other rules of other stock exchanges which are applicable to it;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) the Issuer does not have to publish or update a prospectus or a similar disclosure document which requires approval by a regulatory authority, neither in connection with the issue of the First Tranche Bonds, the issuance and delivery of Shares upon conversion of the First Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds, in each case under or pursuant to the Regulation (EU) 2017/1129 of the European Parliament and of the Council of 14 June 2017, as amended, any other applicable laws or regulations, or any rules and regulations of, or applicable to, each Stock Exchange;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) neither the Issuer nor any of its Subsidiaries nor any of their respective affiliates have entered into any commitment, term sheet, memorandum of understanding, agreement or other contract (whether binding or non-binding) in connection with any mergers, de-mergers, acquisitions or disposals of, or partnerships, joint ventures or similar arrangements in respect of, any businesses, properties and/or assets of the Issuer or any of its Subsidiaries, nor are they currently involved in negotiations or discussions that would contemplate their entry into any such transaction(s); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) other than as disclosed in the Public Statements, neither the Issuer nor any of its Subsidiaries has entered into any contract or commitment or incurred any liability (including any contingent liability) which is (1) outside the ordinary course of business or (2) of an unusual or onerous nature;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) that:

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the annual audited consolidated financial statements of the Issuer and its Subsidiaries for each of the two most recent financial years ended 31 December for which such audited consolidated financial statements have been published; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the interim condensed consolidated financial statements of the Issuer and its Subsidiaries as of and for the end of its most recent interim financial period in respect of which such financial statements are published,

in each case, were prepared in accordance with the requirements of law and with IFRS accounting principles generally accepted in Belgium consistently applied and that they give a true and fair view of its assets, liabilities, financial position and results of the Issuer and its Subsidiaries (on a consolidated basis) as at the dates indicated;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) that since the date falling on the end of its most recent financial year in respect of which audited consolidated financial statements are published:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the Issuer and its Subsidiaries do not have any contingent obligations (including any contingent payment obligations in respect of indebtedness of third parties), liabilities for taxes or other outstanding obligations or liabilities, fixed or contingent, which are material in the aggregate;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) there has been no change nor any development or event involving a prospective change which is materially adverse to the condition (financial or otherwise), business or general affairs, results of operations, properties or profitability of the Issuer and its Subsidiaries (taken as a whole) or the ability of the Issuer to perform its obligations under the First Tranche Bond Documents and the First Tranche Bonds; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) none of the Issuer or any of its Subsidiaries has any material off-balance sheet financing, investments or liabilities to be disclosed in accordance with applicable laws or financial reporting rules;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) that the Issuer and each of its Subsidiaries:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) is not in violation of its certification of incorporation, articles of association or bylaws (or similar organisational or constitutional documents);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) is not in breach of any terms of, or in default under, any indenture, mortgage, deed of trust, loan or credit agreement, lease, licence, order or other agreement or instrument to which it is a party or by which it or its property is bound and no event has occurred which with the giving of notice or lapse of time or other condition would constitute a default under any such indenture, mortgage, deed of trust, loan or credit agreement, lease, licence, order or other agreement or instrument;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) is not engaged (whether as defendant or otherwise) in, nor has the Issuer knowledge of the existence of, or any written threat of, any legal, regulatory, arbitration, administrative, governmental or other proceedings or investigations with respect to the Issuer or any of its Subsidiaries; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) has not taken any action nor, to the best of their knowledge or belief having made all reasonable enquiries, have any steps been taken or legal proceedings commenced for the winding up or dissolution of the Issuer or any of its Subsidiaries;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the dematerialized Shares issued by the Issuer as at the date hereof are and traded on each Stock Exchange in compliance with all applicable listing rules and the Issuer is in compliance with all applicable listing rules relating to the Shares, and it has made all applicable regulatory filings in respect of the listing and admission to trading of the Shares with each Stock Exchange;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) there are no outstanding securities convertible into or exchangeable for, or subscription rights, warrants, rights or options to purchase from the Issuer or any of its Subsidiaries, or obligations, commitments or intentions of the Issuer or any of its Subsidiaries to create the same or to issue, sell or otherwise dispose of, any shares of the Issuer or of any of its Subsidiaries, other than pursuant to the Excluded Instruments and the First Tranche Bonds; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) no authorisation, approval or consent of any governmental authority or agency of Belgium, the United States or of any other jurisdiction is required to effect dividend payments or distributions in respect of any Shares to be delivered upon conversion of the First Tranche Bonds or pursuant to any Share Settlement Option under the First Tranche Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) that each of the Issuer and each of its Subsidiaries has been duly incorporated and is validly existing under the laws of its jurisdiction of incorporation and is not in liquidation, receivership, judicial reorganisation or bankruptcy and has full power and authority to own, lease and operate its properties and conduct its business, (in the case of the Issuer only) to execute and perform its obligations under the First Tranche Bond Documents and the First Tranche Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) that the issue of the First Tranche Bonds, the issuance and delivery of Shares upon conversion of the First Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds and the execution and delivery of the First Tranche Bond Documents have been duly authorised by the Issuer and, in the case of the First Tranche Bonds, upon due execution, issue and delivery in accordance with the First Tranche Bond Instrument will constitute, and, in the case of the First Tranche Bond Documents, upon due execution and delivery (as applicable), constitute, legal, valid and binding obligations of the Issuer enforceable in accordance with their respective terms, subject to the laws of bankruptcy and other laws affecting the rights of creditors generally;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) that the consummation of the Equity Offering, the execution and delivery of the First Tranche Bond Documents, the issuance and delivery of Shares upon conversion of the First Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds, the issue and distribution of the First Tranche Bonds in accordance with the First Tranche Bond Documents and the performance of the terms of the First Tranche Bonds and the First Tranche Bond Documents:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) is not in breach of or will not conflict with, or result in a breach of or constitute a default under, any of the terms or provisions of, or constitute a default under, any indenture, mortgage, deed of trust, loan or credit agreement, lease, licence, order or other agreement or instrument to which the Issuer or any of its Subsidiaries is a party or by which any of them or any of their respective properties or assets are bound;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) will not infringe any law, regulation, order, binding rule, or decree of any government, governmental or regulatory body or court, domestic or foreign, having jurisdiction over the Issuer or any of its Subsidiaries or any of their respective properties or assets;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) infringe the rules of any stock exchange on which securities of the Issuer (including the Stock Exchanges) are listed or contravene Belgian public policy; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) are not contrary to the provisions of the constitutional documents of the Issuer or any of its Subsidiaries or corporate law generally applicable to companies in their country of incorporation;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) all of the Shares as at the date hereof have been duly and validly authorised and issued and are fully paid;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) none of the outstanding share capital of the Issuer has been issued in violation of any pre-emptive rights or similar rights of any shareholder;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) the board of directors of the Issuer has or will have authority to issue and allot, free from pre-emption rights, Shares to enable the conversion rights under the First Tranche Bonds to be satisfied in full pursuant to the First Tranche Conditions (including in respect of the exercise of any Share Settlement Option), and all other rights of subscription and conversion into Shares to be satisfied in full in accordance with the First Tranche Conditions;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) the Shares to be issued and/or delivered upon conversion of the First Tranche Bonds or pursuant to the exercise of a Share Settlement Option under the First Tranche Bonds will be fully paid and will not be subject to calls for further funds and will be free and clear of all liens, charges, pledges, encumbrances, security interest, claims and other third-party rights;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) the Shares to be issued and/or delivered upon conversion of the First Tranche Bonds or pursuant to the exercise of a Share Settlement Option under the First Tranche Bonds will rank *pari passu* with the then outstanding Shares;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) the subscription of the First Tranche Bonds and all Shares to be issued and/or delivered upon conversion of the First Tranche Bonds or pursuant to the exercise of a Share Settlement Option under the First Tranche Bonds will not be subject to any pre-emptive, first-refusal or similar rights arising under applicable law or under the articles of association (or other constitutional documents) of the Issuer in force from time to time, and is not subject to other similar rights arising under applicable law or under such articles of association (or other constitutional document) of the Issuer; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) except as provided by general provisions of Belgian law, there are no restrictions or limitations concerning the voting rights or transfers of the Shares, any declaration or payment of dividends or any other contributions statutorily due to the holders of the Shares whether pursuant to any agreement or otherwise;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(j) all written information provided by or on behalf of the Issuer to the Initial Subscriber under or in connection with the First Tranche Bond Documents was true, complete and accurate in all material respects at the date it was provided or as at the date (if any) at which it is

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stated to be given and did not omit any information which, if disclosed, might make that information untrue or misleading in any material respect;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(k) that no event has occurred which would constitute (if the First Tranche Bond Documents had been duly executed and the First Tranche Bonds were issued and outstanding) an Event of Default, a Potential Event of Default or a Relevant Event (each as defined in the First Tranche Conditions);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(l) that all required consents, approvals, authorisations, orders, filings, registrations or qualifications of or with any court or Governmental Authority or agency of Belgium, the United States or of any other jurisdiction that is applicable to the Issuer and its Subsidiaries have been given, fulfilled or done for or in connection with the execution, issue and distribution of the First Tranche Bonds and compliance by the Issuer with the terms of the First Tranche Bonds, the issuance and delivery of Shares upon conversion of the First Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds, or the execution and delivery of, and compliance with the terms of, the First Tranche Bond Documents;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(m) that the Issuer and its Subsidiaries together own, possess or can acquire on reasonable terms, adequate Intellectual Property Rights necessary to conduct the business now operated by them, or presently employed by them and, to the best of the Issuer's knowledge, have not received any notice of infringement of or conflict with asserted rights of others with respect to any Intellectual Property Rights;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(n) that there are no circumstances, facts or proceedings of which the Issuer or any of its Subsidiaries is aware which indicate that any licences, grants or legal or regulatory approvals, registrations or the like relating to any of their respective actual or prospective Intellectual Property Rights or work products are at a risk of being, have been or will be rejected or otherwise not be granted by the applicable licensing, regulatory, legal or other bodies;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(o) that the Issuer's and its Subsidiaries' information technology assets and equipment, computers, systems, networks, hardware, software, websites, applications, and databases (collectively, the "**IT Systems**") operate and perform in all material respects as required in connection with the operation of their respective businesses as currently conducted and, to the best knowledge of the Issuer, free and clear of all bugs, errors, defects, Trojan horses, time bombs, malware and other corruptants, other than those not reasonably expected to have a Material Adverse Effect. The Issuer and their respective Subsidiaries maintain commercially reasonable controls, policies, procedures, and safeguards to maintain and protect their material confidential information and the integrity, continuous operation, redundancy and security of all IT Systems and all personal, personally identifiable, sensitive, confidential or regulated data (the "**Personal Data**") processed and stored thereon and, to the best knowledge of the Issuer, there have been no breaches, incidents, violations, outages, compromises or unauthorised uses of or accesses to same, except for those that have been remedied without material cost or liability or the duty to notify any other person, nor any incidents under internal review or investigations relating to the same, other than those not reasonably expected to have a Material Adverse Effect. The Issuer and their respective Subsidiaries are presently in compliance in all material respects with all applicable laws and statutes and all applicable judgments, orders, rules and regulations of any court or arbitrator or governmental or regulatory authority, internal policies and contractual obligations relating to the privacy and security of IT Systems and Personal Data

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and to the protection of such IT Systems and Personal Data from unauthorised use, access, misappropriation or modification;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(p) that all real estate currently owned, occupied or leased by the Issuer or any of its Subsidiaries is lawfully owned, occupied or leased by it and any real property held under lease by the Issuer or any of its Subsidiaries is held by them under valid, existing and enforceable leases and does not interfere with the use made or proposed to be made of such property and buildings by the Issuer or any of its Subsidiaries;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(q) all statutory, municipal and other licences, franchises, consents, permits, approvals, orders, authorities and other concessions necessary and material for the carrying on of the businesses and operations of the Issuer and each of its Subsidiaries as now carried on and as previously carried on have been obtained (collectively, "**Licences**") and are (or were at the relevant time) valid and subsisting;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(r) all conditions applicable to any such Licence have been and are complied with and the Issuer and its Subsidiaries are not in breach of any such Licence, except where any such breach could reasonably be expected to result in the Issuer incurring Losses in an amount that is less than U.S.$250,000;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(s) there are no circumstances or proceedings of which the Issuer is aware which indicate that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) any such Licence may be; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) if determined adversely to the Issuer or any of its Subsidiaries, may cause any such Licence to be,

revoked, rescinded, modified, avoided or repudiated or not renewed, in whole or in part, in the ordinary course of events;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(t) that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) neither the Issuer nor any of its Subsidiaries is in violation of any applicable statute, law, rule, regulation, ordinance or rule of civil or common law or any judicial or administrative interpretation thereof, including any judicial or administrative order, consent, decree or judgment, relating to pollution or protection of human health, the environment (including, without limitation, ambient air, surface water, groundwater, land surface or subsurface strata) or wildlife, including, without limitation, laws and regulations relating to the release or threatened release of chemicals, pollutants, contaminants, wastes, toxic substances, hazardous substances, petroleum or petroleum products, asbestos-containing materials or mould (collectively, "**Hazardous Materials**") or to the manufacture, processing, distribution, use, treatment, storage, disposal, transport or handling of Hazardous Materials (collectively, "**Environmental Laws** ");

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the Issuer and each of its Subsidiaries has all Authorisations required under any applicable Environmental Laws and is in compliance with their requirements;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) there are no pending or, to the knowledge and belief of the Issuer, threatened administrative, regulatory or judicial actions, suits, demands, demand letters, claims, liens, notices of non-compliance or violation, investigation or proceedings relating to any Environmental Law against it or any of its Subsidiaries;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) to the best of the Issuer's knowledge, there are no events or circumstances that would reasonably be expected to form the basis of an order for clean-up or remediation, or an action, suit or proceeding by any private party or governmental body or agency, against or affecting the Issuer or any of its Subsidiaries relating to Hazardous Materials or Environmental Laws; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) in the ordinary course of its business, the Issuer periodically reviews the effect of Environmental Laws on the business, operations and properties of the Issuer and each of its Subsidiaries, in the course of which the Issuer identifies and evaluates associated costs and liabilities (including, without limitation, any capital or operating expenditures required for clean-up, closure of properties or compliance with Environmental Laws or any permit, authorisation or approval, any related constraints on operating activities and any potential liabilities to third parties); on the basis of such review, the Issuer has reasonably concluded that such associated costs and liabilities would not, individually or in the aggregate, have a Material Adverse Effect;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(u) that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the Issuer and each of its Subsidiaries has in place all policies of insurance which in the reasonable opinion of the directors of the Issuer are sufficient and are customary for the conduct of their respective businesses as, and in the jurisdiction in which they are, currently operated and for compliance with all applicable requirements of law;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) such policies are in full force and effect;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) all premiums with respect to such policies which are due have been paid;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) no notice of cancellation or termination has been received with respect to any such policy; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) the Issuer and each of its Subsidiaries has complied with the terms and conditions of such policies;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) there are no claims by the Issuer or any of its Subsidiaries under any policy or instrument of insurance as to which any insurance company is denying liability or defending under a reservation of rights clause, and neither the Issuer nor any of its Subsidiaries has been refused any insurance coverage sought or applied; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) neither the Issuer nor any of its Subsidiaries has reason to believe that it will not be able to renew its existing insurance coverage as and when such coverage expires or to obtain similar coverage from similar insurers as may be necessary to continue its business at a cost that would not have a Material Adverse Effect;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(w) that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the Issuer and its Subsidiaries have filed all tax returns, reports and other information required to be filed by it or have properly requested extension thereof, and the Issuer and its Subsidiaries have paid all taxes required to be paid by any of them and, if due and payable, any related or similar assessment, fine or penalty levied against any of them, except as may be being contested in good faith and by

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appropriate proceedings. The Issuer has made adequate charges, accruals and reserves in the applicable financial statements referred to in Clause 7.1(b) (*Representations and Warranties*) in respect of all income and franchise taxes for all periods as to which the tax liability of the Issuer or any of its Subsidiaries has not been finally determined;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) no transaction, stamp duty, stamp duty reserve, registration, transfer, documentary or other similar taxes or duties are payable by or on behalf of the Initial Subscriber in Belgium (except for a stamp duty of EUR 0.15 that is payable for each original copy of an agreement containing a debt obligation, indebtedness or security interest for the benefit of banks that is signed or registered in Belgium), the United States or any other jurisdiction in which the Issuer is resident or treated as doing business in for tax purposes in each case in connection with the authorisation, execution or delivery of the First Tranche Bond Documents, the authorisation, execution, issue or delivery of the First Tranche Bonds, the issuance and delivery of Shares upon conversion of the First Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds, or the performance of the obligations of the Issuer under the First Tranche Bond Documents and the First Tranche Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) the Issuer is and has been exclusively resident for all tax purposes and subject to taxation in Belgium only, and has not at any time been resident or had any branch, agency or permanent establishment in any other jurisdiction for any tax purpose and no tax authority has ever sought to assert the same;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) neither the Issuer nor any of its Subsidiaries has incurred any liability (or has committed any actions, or events have occurred, which would subject the Issuer or any of its Subsidiaries to a liability) in respect of any tax; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) neither the Issuer nor any of its Subsidiaries has paid nor is liable to pay nor has acted (directly or through an agent or other representative) in such manner as to incur a liability (or potential liability) to pay any interest or penalty in connection with any tax or otherwise paid any tax after its due date for payment or become liable to pay any tax;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(x) that the Issuer and each of its Subsidiaries maintains a system of internal accounting controls which, in the reasonable opinion of the Issuer, is sufficient to provide reasonable assurance that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) transactions are executed in accordance with management's general or specific authorisations;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) transactions are recorded as necessary to (A) permit preparation of financial statements in conformity with IFRS accounting principles generally accepted in Belgium, and (B) maintain accountability for assets; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) the Issuer and each of its Subsidiaries has made and kept books, records and accounts which, in reasonable detail, accurately and fairly reflect the transactions and dispositions of assets of such entity and provide a sufficient basis for the preparation of the Issuer's consolidated financial statements in accordance with IFRS accounting principles generally accepted in Belgium;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(y) that neither the Issuer nor any of its Subsidiaries nor any of their respective directors, officers or employees nor, to the best of the Issuer's knowledge, any agent or affiliate of the Issuer or any of its Subsidiaries is currently the subject or the target of any Sanctions or conducting business with any person, entity or country which is the subject or target of any Sanctions in a manner which is prohibited by such Sanctions;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(z) that neither the Issuer nor any of its Subsidiaries nor any of their respective directors, officers or employees nor, to the best of the Issuer's knowledge, any agent or affiliate of the Issuer or any of its Subsidiaries:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) has engaged in any activity or conduct which would violate any applicable anti-bribery or anti-corruption laws or regulations (including. without limitation. to the extent applicable. the U.S. Foreign Corrupt Practices Act of 1977 or the rules and regulations promulgated thereunder. or under the UK Bribery Act 2010) ()"**Anti-Bribery and Anti-Corruption Laws** ");

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) has offered, promised, paid, received, requested or agreed to receive a bribe or other unlawful payment nor offered, promised or given any financial or other advantage to a public official (or to a third party) at the request or acquiescence of the public official in an attempt to influence them in their capacity as a public official to obtain or retain business, or to obtain an advantage in the conduct of business, where such offer, promise or payment is not permitted under applicable laws (a "**Prohibited Payment** "); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) has been or is, to the best of the Issuer's knowledge, subject to any investigation by any governmental entity, or any action, suit or proceeding by or before any court or governmental agency, authority or body or any arbitrator with regard to any actual or alleged Prohibited Payment or violation of Anti-Bribery and Anti-Corruption Laws, and, to the best of the Issuer's knowledge, no such actions, suits or proceedings are threatened or contemplated.

The Issuer has instituted, maintains and enforces systems, controls, policies and procedures for the purpose of preventing it and its directors and officers, employees and any other persons acting on its or their behalf from engaging in any action in breach of Anti-Bribery and Anti-Corruption Laws;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(aa) that the operations of the Issuer and each of its Subsidiaries are and have been conducted at all times in compliance with applicable financial record keeping and reporting requirements and money laundering statutes in Belgium, the European Union and of all jurisdictions in which the Issuer and each of its Subsidiaries conduct business, the rules and regulations thereunder and any related or similar rules, regulations or guidelines, issued, administered or enforced by any governmental agency and which is binding on the Issuer or any of its Subsidiaries (collectively, the "**Money Laundering Laws**") and no action, suit or proceeding by or before any court or governmental agency, authority or body or any arbitrator involving the Issuer or any of its Subsidiaries with respect to Money Laundering Laws is pending and, to the best of the Issuer's knowledge, no such actions, suits or proceedings are threatened or contemplated. The Issuer has instituted, maintains and enforces systems, controls, policies and procedures for the purpose of preventing it and its directors and officers, employees and any other persons acting on its or their behalf from engaging in any action in breach of Money Laundering Laws;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(bb) that the First Tranche Bonds will, upon issue, constitute direct, unconditional, unsubordinated (subject to Condition 1.4 (*Subordination*)) and unsecured obligations of

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the Issuer ranking *pari passu* and rateably, without any preference among themselves, and at least equally with all other existing and future unsecured and unsubordinated obligations of the Issuer but, in the event of an insolvency of the Issuer, save for such obligations that may be preferred by provisions of law that are mandatory and of general application;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(cc) that the Issuer has not entered, and will not enter, into any contractual arrangement with respect to the distribution of the First Tranche Bonds except for this Agreement and the Term Sheet or any supplementary or ancillary documentation related thereto;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(dd) that neither the Issuer nor any of its Subsidiaries is engaged in any transactions with its directors, officers, management, shareholders, or any other person, including persons formerly holding such positions, on terms that are not available from other parties on an arm's-length basis and otherwise are on ordinary commercial terms;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ee) that the issue and sale of the First Tranche Bonds by the Issuer on the First Tranche Closing Date will not result in a breach of any provisions relating to financial assistance, principles of corporate benefit or any similar analogous law or regulation in the jurisdictions of its incorporation which could invalidate the enforceability of the First Tranche Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ff) that the First Tranche Bonds and the issuance and delivery of Shares upon conversion of the First Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds have not been and will not be registered under the Securities Act and have not been registered or qualified under any state securities or "Blue Sky" laws of the states of the United States and, accordingly, the Issuer acknowledges that the First Tranche Bonds and the issuance and delivery of Shares upon conversion of the First Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds may not be offered or sold within the United States or to or for the account or benefit of U.S. persons except in accordance with Regulation S or pursuant to another exemption from the registration requirements of the Securities Act (terms used in this paragraph have the meaning given to them by Regulation S);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(gg) that the Issuer is a "foreign issuer" (as such term is defined in Regulation S);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(hh) that none of the Issuer nor any of its affiliates, nor any persons acting on any of their behalf, has engaged or will engage in any directed selling efforts (as defined in Rule 902(c) under the Securities Act) with respect to the First Tranche Bonds or the Shares issuable upon exercise of any Share Settlement Option under the First Tranche Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) each of the Issuer and its affiliates will comply with the offering restrictions requirement of Regulation S under the Securities Act and will not make any offers or sales of the First Tranche Bonds or the Shares issuable upon exercise of any Share Settlement Option under the First Tranche Bonds to a US person or for the account or benefit of a US person prior to the expiration of the 40 day distribution compliance period specified in Rule 903(b)(2) of Regulation S; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(jj) no registration under the Securities Act of the First Tranche Bonds and any Shares issued and delivered upon conversion of the First Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds will be required for the offer, sale and delivery of the First Tranche Bonds and any Shares issued and delivered upon conversion of the First Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds to the Initial Subscriber in the manner contemplated by the First Tranche Bond Documents.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**7.2** **Representations and Warranties on the Second Tranche Closing Date** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Subject to paragraph (b) below, the Issuer shall make the representations and warranties set out above in Clause 7.1 (*Representations and Warranties*) to the Initial Subscriber in respect of the First Tranche Bond and the Second Tranche Bonds on the date of the Second Tranche Request Notice and, by reference to the facts and circumstances then subsisting, on the Second Tranche Closing Date and each intervening day.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) For the purposes of paragraph (a) above, the representations and warranties Clause 7.1 (*Representations and Warranties*) shall be deemed to be modified with effect from the date of the Second Tranche Request Notice as follows:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) unless otherwise modified by this Clause:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) any reference to the First Tranche Bonds shall be construed to include reference to the Second Tranche Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) any reference to the First Tranche Bond Documents shall be construed to include reference to the Second Tranche Bond Documents;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(C) any reference to the First Tranche Conditions shall be construed to include reference to the Second Tranche Conditions; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(D) any reference to the First Tranche Closing Date shall be construed to include reference to the Second Tranche Closing Date;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) Clause 7.1(k) (*Representations and Warranties*) shall be deleted in its entirety and replaced with the following words:

"that no event has occurred which would constitute (if the Second Tranche Bond Documents had been duly executed and the Second Tranche Bonds were issued and outstanding) an Event of Default, a Potential Event of Default or a Relevant Event (each as defined in the First Tranche Conditions and the Second Tranche Conditions);";

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) Clause 7.1(l) (*Representations and Warranties*) shall be deleted in its entirety and replaced with the following words:

"all required consents, approvals, authorisations, orders, filings, registrations or qualifications of or with any court or Governmental Authority or agency of Belgium, the United States or of any other jurisdiction that is applicable to the Issuer and its Subsidiaries have been given, fulfilled or done for or in connection with the execution, issue and distribution of the Second Tranche Bonds and compliance by the Issuer with the terms of the First Tranche Bonds and the Second Tranche Bonds, the issuance and delivery of Shares upon conversion of the First Tranche Bonds and the Second Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds and the Second Tranche Bonds, as the case may be, or the execution and delivery of, and compliance with the terms of, the First Tranche Bond Documents and the Second Tranche Bond Documents;"; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) Clause 7.1(bb) (*Representations and Warranties*) shall be deleted in its entirety and replaced with the following words:

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"that the Second Tranche Bonds will, upon issue, and the First Tranche Bonds currently constitute direct, unconditional, unsubordinated and unsecured obligations of the Issuer ranking pari passu and rateably, without any preference among themselves, and at least equally with all other existing and future unsecured and unsubordinated obligations of the Issuer but, in the event of an insolvency of the Issuer, save for such obligations that may be preferred by provisions of law that are mandatory and of general application;".

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**8.** **Representations of the Initial Subscriber** 

The Initial Subscriber represents, warrants and confirms to the Issuer on the date of this Agreement (in the case of the First Tranche Bonds) and on the date of its acceptance of a Second Tranche Notice Request (in the case of the Second Tranche Bonds) as follows:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) that it has been duly incorporated and is validly existing and registered in its jurisdiction of incorporation and is not in liquidation, receivership or bankruptcy and it has full power and authority to execute and perform its obligations under this Agreement;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) that it understands that the First Tranche Bonds, Second Tranche Bonds, the Shares to be issued and delivered upon conversion of the First Tranche Bonds or Second Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds or Second Tranche Bonds, as the case may be, have not been and will not be registered under the Securities Act or with any securities regulatory authority of any state or other jurisdiction of the United States and that any offer and sale of the First Tranche Bonds, Second Tranche Bonds, the Shares to be issued and delivered upon conversion of the First Tranche Bonds or Second Tranche Bonds or upon exercise of any Share Settlement Option under the First Tranche Bonds or Second Tranche Bonds, as the case may be, to it is being made in reliance on an exemption from, or in a transaction not subject to, the registration requirements of the Securities;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) that its purchase of the First Tranche Bonds or Second Tranche Bonds, as the case may be, is lawful under the laws of the jurisdiction of its incorporation and the jurisdiction in which it operates (if different), and that such acquisition will not contravene any law, regulation or regulatory policy applicable to it;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) that it is not a U.S. person (as such term is defined in Regulation S) and is not acting for the account or benefit of a U.S. person;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) that it is not a "distributor" (as such term is defined in Regulation S);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) that it is a "qualified investor" as defined under Article 2 of Regulation (EU) 2017/1129;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) that it is acquiring the First Tranche Bonds or Second Tranche Bonds, as the case may be, for its own account, or for one or more accounts (and as to each of which it has authority to acquire the First Tranche Bonds or Second Tranche Bonds, as the case may be, and exercise sole investment discretion), for investment purposes, and not with a view to, or for resale in connection with, the distribution thereof, directly or indirectly, in whole or in part, in the United States in violation of the Securities Act and that neither it nor any account for which it is acting (if any) was formed for the specific purpose of acquiring the First Tranche Bonds or Second Tranche Bonds, as the case may be; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) that it understands that the First Tranche Bonds, Second Tranche Bonds, the Shares issuable upon conversion of the First Tranche Bonds or Second Tranche Bonds, or the

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Shares issuable upon exercise of any Share Settlement Option under the First Tranche Bonds or Second Tranche Bonds, as the case may be, may only be resold or otherwise transferred pursuant to an effective registration statement or in in a transaction exempt from, or not subject to, the registration requirements of the Securities Act, and in compliance with applicable state securities law, and that the Issuer is not required to register the First Tranche Bonds or the Second Tranche Bonds, as the case may be, under the Securities Act.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**9.** **Undertakings by the Issuer** 

The Issuer undertakes with the Initial Subscriber as follows:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) it will forthwith notify the Initial Subscriber if at any time anything occurs which renders or which it is aware might reasonably be expected to render untrue or incorrect in any respect any of the representations and warranties contained in Clause 7 (*Representations and Warranties*);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) to the extent that any amendments, variations or modifications are made to the constitutional documents (including its articles of association) of the Issuer, the Issuer shall forthwith promptly notify the Initial Subscriber and provide it with a copy of the updated documents and an explanation of the amendments, variations or modifications that have been made;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) between either, as the case may be,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the date hereof and the First Tranche Closing Date (both dates inclusive); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the date of the Second Tranche Request Notice and the Second Tranche Closing Date (both dates inclusive),

it will not do any act or thing which, had the First Tranche Bonds or Second Tranche Bonds (as the case may be) then been in issue, would result in an adjustment to the Conversion Price (as defined in the First Tranche Conditions or the Second Tranche Conditions, as applicable). In the case of the First Tranche Bonds, the foregoing sentence shall not apply to any such adjustment to the Conversion Price which, had such First Tranche Bonds then been in issue, would have been triggered by the Equity Offering;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) it will use the proceeds from the issue of the Bonds of each Series and the Equity Offering for general corporate purposes;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) to the extent any the Shares issuable upon conversion of the Bonds of either Series, or the Shares issuable upon exercise of any Share Settlement Option under the Bonds of either Series are to be delivered to any holder of such Bonds pursuant to the terms of the relevant Bond Documents (as the case may be), that such Shares shall be freely tradeable shares under applicable securities laws at the time of delivery and will not bear legends noting restrictions as to resale of such securities under US federal or state securities laws nor be subject to stop transfer instructions and such Shares will delivered to the account identified by such holder of Bonds in DTC or Euroclear Belgium in accordance with the terms and in the manner contemplated by the relevant Bond Documents;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) it will not, and it shall procure that its Subsidiaries will not, directly or indirectly use all or part of the proceeds of the offering of the Bonds of each Series and the Equity Offering, or

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lend, contribute or otherwise make available all or part of such proceeds to any subsidiary, joint venture partner or other person:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) to fund or facilitate any activities of or business with any person that, at the time of such funding or facilitation, is the subject or the target of applicable Sanctions;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) to fund or facilitate any activities of or business in any country or territory, that is, or whose government is, the subject of any Sanctions at the time of such funding or financing;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) in any other manner that will result in a violation by the Issuer or any of its Subsidiaries of applicable Sanctions;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) in connection with any Prohibited Payment; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) in any manner that would contravene any applicable Money Laundering Laws and Anti-Bribery and Anti-Corruption Laws;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) the Issuer will ensure that all announcements and documents published or statements made by it or on its behalf, which refer to the Initial Subscriber (including Heights Capital Management, Inc., Heights Capital Ireland, LLC and/or any of their respective affiliates) by name will only be made or published with the prior written consent of the Initial Subscriber (such consent to be withheld at the Initial Subscriber's sole and absolute discretion) and will be true and accurate in all material respects and not misleading in any material respect and, where appropriate, will contain all information necessary for legal or regulatory purposes and all opinions included will be honestly held and given after due and careful consideration. Nothing in this paragraph shall restrict the Issuer from at any time making any disclosure or announcement which is required by any applicable law, regulation, stock exchange rule, judicial or regulatory order, or any tax authority or other Governmental Authority, *provided that* where such disclosure or announcement is required and, to the extent permitted by the relevant law, regulation, stock exchange rule, judicial or regulatory order, tax authority or other Governmental Authority, the Issuer shall promptly notify the Initial Subscriber and provide to the Initial Subscriber the relevant announcement, document or statement for its prior review and consent (such consent not to be unreasonably withheld, conditioned or delayed);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) each of the Issuer and the Initial Subscriber acknowledge that the Issuer intends to publish (on one or more occasions) a public announcement in connection with its offering, sale and issuance of the First Tranche Bonds, the Second Tranche Bonds and the transactions contemplated by this Agreement, but in each case without referring to the Initial Subscriber (including Heights Capital Management, Inc., Heights Capital Ireland, LLC and/or any of their respective affiliates) by name (each such announcement, a "**Transaction Press Release** "). The Issuer hereby undertakings that it shall not:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) publish or otherwise make available to the public any such Transaction Press Release without the contents thereof being approved in writing by the Initial Subscriber; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) modify, vary, amend or otherwise change the content of any Transaction Press Release approved by the Initial Subscriber pursuant to paragraph (i) above without its prior consent in writing.

Nothing in this paragraph shall restrict the Issuer from at any time making any disclosure or announcement which is required by any applicable law, regulation, stock exchange rule,

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judicial or regulatory order, or any tax authority or other Governmental Authority, *provided that* where such disclosure or announcement is required and, to the extent permitted by the relevant law, regulation, stock exchange rule, judicial or regulatory order, tax authority or other Governmental Authority, the Issuer shall promptly notify the Initial Subscriber and provide to the Initial Subscriber the relevant announcement, document or statement for its prior review and consent (such consent not to be unreasonably withheld, conditioned or delayed); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) between the date of this Agreement and the First Tranche Closing Date (inclusive), the Issuer shall comply, and the Issuer shall procure that each of its Subsidiaries will comply, with the provisions of Condition 2 (*Covenants*) of the First Tranche Conditions.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**10.** **Notices** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**10.1** **Communications in Writing** 

Any communication to be made under or in connection with this Agreement or the Bonds of any Series shall be made in writing and, unless otherwise stated, may be made by email or letter.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**10.2** **Addresses** 

The address and email address (and the department or officer, if any, for whose attention the communication is to be made) of each Party for any communication or document to be made or delivered under or in connection with this Agreement or the Bonds of any Series is:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) in the case of the Issuer:

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| | |
|:---|:---|
| Address: | [\*\*\*] |
| Email: | [\*\*\*] |
| Attention: | [\*\*\*] |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) In the case of the Initial Subscriber:

**CVI Investments, Inc.**

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| | |
|:---|:---|
| Address: | [\*\*\*] |
| Email: | [\*\*\*] |
| Attention: | [\*\*\*] |

---

or any substitute address or email address or department or officer as the Party may notify to the other Parties by not less than five Business Days' notice.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**10.3** **Effectiveness** 

Any notice given under this Agreement shall take effect, in the case of a letter, at the time of delivery, or in the case of email transmission, at the time of despatch (unless a delivery failure notification is received by the sender within 12 hours of sending such communication, in which case such notice shall be deemed not to have taken effect). If such delivery or despatch is made after 5:00 p.m. (Brussels time) or on a day which is not a Brussels business day (in respect of matters where only Brussels business days are specified) or Business Day (in respect of all other matters), such delivery shall be deemed to have been made on the next following Brussels business day or Business Day, as applicable.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**11.** **Confidential Information** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**11.1** **Confidentiality** 

Each Party agrees to keep all Bond Documents and their contents (the "**Confidential Information**") strictly confidential and not to disclose any Confidential Information to any person, save to the extent permitted by Clause 11.2 (*Disclosure of Confidential Information*).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**11.2** **Disclosure of Confidential Information** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Each Party may disclose Confidential Information:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) on a confidential basis to the accountants, legal counsels and other professional advisors retained by the Issuer and the Initial Subscriber, respectively; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) as required by applicable law, regulation, stock exchange rules, judicial or regulatory order, or any tax authority or other Governmental Authority, after consultation with the other Parties (to the extent permitted by the relevant law, regulation, stock exchange rule, judicial or regulatory order, tax authority or other Governmental Authority); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) to the extent that one of the Parties needs to disclose the same for the exercise, protection of enforcement of its rights under the Bond Documents or the Bonds of any Series,

and no Party may disclose Confidential Information to any other person (other than, in the case of the Initial Subscriber, any of its affiliates, agents, management entities or funds under common management or control and having made them aware of the confidential nature of such disclosures) without the prior written consent of the other Parties.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Each Bondholder may disclose Confidential Information to any person (having made them aware of the confidential nature of such disclosure) in connection with the potential transfer of Bonds or assignment or novation of their rights, benefits and/or obligations under this Agreement and the Bonds of any Series (or discussions in relation thereto) to any potential transferee.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**11.3** **Restricted Information** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) The Issuer shall not (without first entering into a separate confidentiality agreement with the Initial Subscriber) provide the Initial Subscriber with any Restricted Information regarding the Bonds of each Series, the Shares, the Issuer or any of its Subsidiaries.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) In relation to any Restricted Information disclosed by the Issuer (or on its behalf) to the Initial Subscriber on or prior to the First Tranche Closing Date, the Issuer shall (in consultation with the Initial Subscriber) do whatever is necessary to ensure that such Restricted Information is publicly disclosed to the market in accordance with applicable laws, regulations or rules (including, for the avoidance of doubt, by way of announcement through a Regulatory Information Service and Form 6-K (or similar)) or as otherwise may be effective so as to ensure that, by no later than the First Tranche Closing Date, the Initial Subscriber is no longer in possession of Restricted Information and is no longer restricted from trading in any securities or instruments of the Issuer or any of its Subsidiaries or any other person by reason of the receipt of that Restricted Information.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Notwithstanding Clause 11.3(b) above, the Issuer shall (in consultation with the Initial Subscriber) do whatever is necessary to ensure that such Restricted Information is publicly disclosed to the market in accordance with applicable laws, regulations or rules (including, for the avoidance of doubt, by way of announcement through a Regulatory Information Service and Form 6-K (or similar)) or as otherwise may be effective so as to ensure that, within two Brussels business days of written demand by the Initial Subscriber (acting reasonably) (which may be by email and in accordance with Clause 10 (*Notices*)), the Initial Subscriber is no longer in possession of Restricted Information and is no longer restricted from trading in any securities or instruments of the Issuer or any of its Subsidiaries or any other person by reason of the receipt of that Restricted Information.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**12.** **Payments** 

All payments in respect of the obligations of the Issuer under this Agreement shall be made free and clear of, and without withholding or deduction for or on account of, any taxes, duties, assessments or governmental charges of whatever nature imposed, levied, collected, withheld or assessed by or on behalf of, any tax jurisdiction applicable to the Issuer or any political subdivision or any authority thereof or therein having power to tax, unless such withholding or deduction is required by law. In that event, the Issuer shall pay such additional amounts as will result in the receipt by the Initial Subscriber of such amounts as would have been received by it if no such withholding or deduction had been required.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**13.** **Set-off and Counterclaims** 

The Issuer may not apply or perform any counterclaims or set-off against any payment obligations pursuant to this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**14.** **Severability** 

If any provision in or obligation under this Agreement is or becomes invalid, illegal or unenforceable in any respect under the law of any jurisdiction, that will not affect or impair (a) the validity, legality or enforceability under the law of that jurisdiction of any other provision in or obligation under this Agreement, and (b) the validity, legality or enforceability under the law of any other jurisdiction of that or any other provision in or obligation under this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**15.** **Remedies and Waivers** 

No failure or delay by any Party to exercise any right or remedy provided under this Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it prevent or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall prevent or restrict the further exercise of that or any other right or remedy.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**16.** **Assignment and Transfers** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**16.1** **Assignments and Transfers by the Issuer** 

The Issuer may not assign any of its rights or transfer any of its rights or obligations under this Agreement.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**16.2** **Assignments and Transfers by the Initial Subscriber** 

Without prejudice to any transfer restrictions regarding the First Tranche Bonds or Second Tranche Bonds set out in the relevant Bond Documents, the Initial Subscriber may assign any of its rights or transfer by novation any of its rights and obligations under this Agreement to:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) any investment vehicle, including, any funds, feeder funds or managed accounts, currently, or from time to time after the First Tranche Closing Date, directly or indirectly managed or advised by the Initial Subscriber's investment manager or any of its affiliates or principals; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) any direct or indirect affiliates of the Initial Subscriber or any of the foregoing.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**17.** **Survival** 

The obligations of the Issuer pursuant to Clauses 5 (*Indemnification of the Initial Subscriber*), 6 (*Costs and Expenses*), 9 (*Undertakings by the Issuer*), 10 (*Notices*), 11 (*Confidential Information*), 12 (*Payments*), 14 (*Severability*), 15 (*Remedies and Waivers*), 18 (*Amendments and Waivers*), 19 (*Counterparts*), and 20 (*Governing Law and Jurisdiction*) shall survive any termination, cancellation or expiry of obligations under this Agreement (including, for the avoidance of doubt, following the consummation of this Agreement upon the occurrence of the First Tranche Closing Date or Second Tranche Closing Date, as the case may be).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**18.** **Amendments and Waivers** 

The Parties may, in their absolute discretion, agree in writing to any modification, alteration or addition to this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**19.** **Counterparts** 

This Agreement may be executed in any number of counterparts, and this has the same effect as if the signatures on the counterparts were on a single copy of this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**20.** **Entire Agreement** 

This Agreement contains the entire agreement between the Parties with respect to the subject matter covered hereby and supersedes all earlier agreements and understandings, whether oral, written or otherwise, between the Parties.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**21.** **Governing Law and Jurisdiction** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**21.1** **Governing Law** 

This Agreement, and any non-contractual obligations arising out of or in connection with it, are and shall be governed by, and construed in accordance with, English law.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**21.2** **Jurisdiction** 

The Issuer agrees for the benefit of the Initial Subscriber that the courts of England shall have exclusive jurisdiction to hear and determine any suit, action or proceedings arising out of or in connection with this Agreement (including any non-contractual obligations arising out of or in

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

connection with this Agreement) ("**Proceedings**") and, for such purposes, irrevocably submits to the jurisdiction of such courts. Nothing in this paragraph shall (or shall be construed so as to) limit the right of the Initial Subscriber to take Proceedings in any other court of competent jurisdiction, nor shall the taking of Proceedings in any one or more jurisdictions preclude the taking of Proceedings by the Initial Subscriber in any other jurisdiction (whether concurrently or not) if and to the extent permitted by law.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**21.3** **Appropriate Forum** 

For the purpose of Clause 21.2 (*Jurisdiction*), the Issuer irrevocably waives any objection which it might now or hereafter have to the courts of England being nominated as the forum to hear and determine any Proceedings and agrees not to claim that any such court is not a convenient or appropriate forum.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**21.4** **Service of Process** 

The Issuer agrees that the process by which any Proceedings are commenced in England pursuant to Clause 21.2 (*Jurisdiction*) may be served on it by being delivered to Law Debenture Corporate Services Limited at its registered office from time to time. If such person is not or ceases to be effectively appointed to accept service of process on behalf of the Issuer, the Issuer shall promptly appoint a further person in England to accept service of process on its behalf. Nothing in this paragraph shall affect the right of the Initial Subscriber to serve process in any other manner permitted by law.

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**Schedule 1**

**First Tranche Conditions Precedent**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. **Approvals and Authorisations** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) A copy of the deed of incorporation and the latest coordinated version of the articles of association of the Issuer.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) A copy of (i) an extract from the Crossroads Bank for Enterprises (*Kruispuntbank van Ondernemingen/Banque-Carrefour des Entreprises*) and (ii) an online search on the website of the Central Solvency Register (*Centraal Register Solvabiliteit/Registre Central de la Solvabilité*), each of items (i) and (ii) above being no older than one Business Day prior to the date of this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) A certified copy of the resolutions of the general meetings of the shareholders of the Issuer authorising the board of directors of the Issuer to issue new Shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) A certified copy of a resolution of the board of directors of the Issuer:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) approving and ratifying the execution of the First Tranche Bond Documents, the issue of the First Tranche Bonds and the consummation of the transactions contemplated by the First Tranche Bond Documents and the Equity Offering;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) authorising a specified person or persons to execute the First Tranche Bond Documents to which it is a party on its behalf; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) authorising a specified person or persons, on its behalf, to sign and/or despatch all documents and notices to be signed and/or despatched by it under or in connection with the First Tranche Bond Documents to which it is a party.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) A certified copy of the reports of the Issuer's board of directors and statutory auditor related to the issue of the First Tranche Bonds

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) A copy of the nihil obstat letter from the Belgian Financial Services and Markets Authority related to the above reports or, in the case the Belgian Financial Services and Markets Authority has not responded within 15 calendar days after filing such reports, a certification in writing by the Issuer that no comments were raised by the Belgian Financial Services and Markets Authority.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) A list of the specimen of the signature of each person authorised by the resolution referred to in paragraph (ii) above.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. **Legal opinion** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Legal opinion of NautaDutilh BV/SRL, legal advisers to the Issuer as to matters of Belgian law, substantially in a form and substance satisfactory to Initial Subscriber.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Legal opinion of the legal advisers to the Issuer as to matters of English law, substantially in a form and substance satisfactory to Initial Subscriber.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3. **Other documents and evidence** 

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) An executed copy of each of the First Tranche Bond Documents (other than the First Tranche Bond Certificate).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) A certificate dated the First Tranche Closing Date and signed by a Director of the Issuer certifying the truth and accuracy of the approvals and authorisations of the Issuer and an extract of the First Tranche Register, in substantially the form set out in Schedule 4 (*Form of Corporate Certificate*).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) A certificate dated the First Tranche Closing Date and signed by a Director of the Issuer confirming, among other things, the matters specified in Clauses 3.1(a)(ii), 3.1(a)(iii) and 3.1(a)(iv) (*Conditions Precedent to First Tranche Closing*), substantially in the form set out in Schedule 5 (*Form of Closing Certificate*).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) The satisfaction of all of the Initial Subscriber's necessary "know your customer" and/or other similar checks under its internal requirements and applicable laws and regulations (which is currently expected to be provision of a completed W-8 BEN-E (or W-9) tax form from the Issuer or any other account recipient, contacts in the Issuer who can verify wire transfer details and signed bank account details on the Issuer's letterhead), in relation to this Agreement, the First Tranche Bonds and the transactions contemplated thereby and the Issuer has provided all such relevant information in relation thereto.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) A written acceptance of Law Debenture Corporate Services Limited of its appointment in respect of this Agreement and the First Tranche Bond Documents as set out therein.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) Confirmation that the entering into of the First Tranche Bond Documents and issuance of the First Tranche Bonds and performance of obligations thereunder is not restricted by and does not result in any breach of or non-compliance with the terms of the agreements between the Issuer and the European Investment Bank (including as to which limb of paragraph 15 of Schedule H of the EIB Facility (as defined in the First Tranche Conditions) applies to the First Tranche Bonds), in a form and substance satisfactory to Initial Subscriber.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) A copy of any other authorisation or other document, opinion or assurance which the Initial Subscriber considers (in good faith) to be reasonably necessary (if it has notified the Issuer accordingly within a reasonable time) in connection with the entry into and performance of the transactions contemplated by any First Tranche Bond Document or for the validity and enforceability of any First Tranche Bond Document.

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**Schedule 2**

**Second Tranche Conditions Precedent**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. **Approvals and Authorisations** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) A copy of the deed of incorporation and the latest coordinated version of the articles of association of the Issuer.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) A copy of (i) an extract from the Crossroads Bank for Enterprises (*Kruispuntbank van Ondernemingen/Banque-Carrefour des Entreprises*) and (ii) an online search on the website of the Central Solvency Register (*Centraal Register Solvabiliteit/Registre Central de la Solvabilité*), each of items (i) and (ii) above being no older than one Business Day prior to the date of this Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) A certified copy of the resolutions of the general meetings of the shareholders of the Issuer authorising the board of directors of the Issuer to issue new Shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) A copy of a resolution of the board of directors of the Issuer:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) approving and ratifying the execution of the Second Tranche Bond Documents, the issue of the Second Tranche Bonds and the consummation of the transactions contemplated by the Second Tranche Bond Documents;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) authorising a specified person or persons to execute the Second Tranche Bond Documents on its behalf; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) authorising a specified person or persons, on its behalf, to sign and/or despatch all documents and notices to be signed and/or despatched by it under or in connection with the Second Tranche Bond Documents;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) A certified copy of the reports of the Issuer's board of directors and statutory auditor related to the issue of the Second Tranche Bonds.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) A copy of the nihil obstat letter from the Belgian Financial Services and Markets Authority related to the above reports or, in the case the Belgian Financial Services and Markets Authority has not responded within 15 calendar days after filing such reports, a certification in writing by the Issuer that no comments were raised by the Belgian Financial Services and Markets Authority.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) A list of the specimen of the signature of each person authorised by the resolution referred to in paragraph (ii) above  *.*** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. **Legal opinion** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Legal opinion of NautaDutilh BV/SRL, legal advisers to the Issuer as to matters of Belgian law, substantially in a form and substance satisfactory to Initial Subscriber.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Legal opinion of the legal advisers to the Issuer as to matters of English law, substantially in a form and substance satisfactory to Initial Subscriber.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3. **Other documents and evidence** 

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) An executed copy of each of the Second Tranche Bond Documents (other than the Second Tranche Bond Certificate).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) A certificate dated the Second Tranche Closing Date and signed by a Director of the Issuer certifying the truth and accuracy of the approvals and authorisations of the Issuer and an extract of the Second Tranche Register, in substantially the form set out in Schedule 4 (*Form of Corporate Certificate*).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) A certificate dated the Second Tranche Closing Date and signed by a Director of the Issuer confirming, among other things, the matters specified in Clauses 4.6(a)(ii), 4.6(a)(iii) and 4.6(a)(iv) (*Conditions Precedent to Second Tranche Closing*), substantially in the form set out in Schedule 5 (*Form of Closing Certificate*).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) A written acceptance of a Law Debenture Corporate Services Limited of its appointment in respect of the Second Tranche Bond Documents as set out therein.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) Confirmation that the entering into of the Second Tranche Bond Documents and issuance of the Second Tranche Bonds and performance of obligations thereunder is not restricted by and does not result in any breach of or non-compliance with the terms of the agreements between the Issuer and the European Investment Bank (including as to which limb of paragraph 15 of Schedule H of the EIB Facility (as defined in the Second Tranche Conditions) applies to the Second Tranche Bonds), in a form and substance satisfactory to Initial Subscriber.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) A copy of any other authorisation or other document, opinion or assurance which the Initial Subscriber considers (in good faith) to be reasonably necessary (if it has notified the Issuer accordingly within a reasonable time) in connection with the entry into and performance of the transactions contemplated by any Second Tranche Bond Document or for the validity and enforceability of any Second Tranche Bond Document.

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**Schedule 3**

**Form of Second Tranche Request Notice**

To: CVI Investments, Inc. (the "**Initial Subscriber**")

[●]<sup>1</sup>

To whom it may concern,

**Second Tranche of €-denominated Amortising Senior Unsecured Convertible Bonds to be issued by Nyxoah SA (the "Issuer")**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. We refer to the Subscription Agreement between the Issuer and the Initial Subscriber dated 13 November 2025 (as amended or supplemented from time to time, the "**Subscription Agreement** "). This is a Second Tranche Request Notice. Terms defined in the Subscription Agreement have the same meaning in this Second Tranche Request Notice, unless otherwise defined herein.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. Subject to the terms and conditions of the Subscription Agreement, we hereby notify you that we shall issue, for your subscription, Second Tranche Bonds on the following terms:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Principal Amount of Second Tranche Bonds: €22,500,000<sup>2</sup>

(b) Second Tranche Closing Date is [ ● ] 20[ ● ]<sup>3</sup> (or such date as may be agreed in writing (including by email) between the Parties).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3. This Second Tranche Request Notice is irrevocable.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4. This Second Tranche Request Notice and any non-contractual obligations arising out of or in connection with it shall be governed by, and construed in accordance with, English law.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5. The provisions of Clause 20 (*Governing Law and Jurisdiction*) of the Subscription Agreement shall apply (with any necessary changes to such provisions being made) to this Second Tranche Request Notice as if set out fully herein.

Yours faithfully,

____________________________

*duly authorised*<br>for and on behalf of<br>**NYXOAH SA**

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<sup>1</sup> *Note: This Notice must be delivered no later than five Business Days prior to the proposed Second Tranche Closing Date.*

<sup>2</sup> *Note: If the principal amount is intended to be less than €22,500,000, the Initial Subscriber's agreement must be obtained before this notice is delivered.*

<sup>3</sup> *Note: Must be no later than five Business Days from the date of this notice, unless otherwise agreed in writing by the Initial Bondholder.*

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**Schedule 4**

**Form of Corporate Certificate**

*[Letterhead of the Issuer]*

**Corporate Certificate**

**CVI Investments, Inc.**<br>c/o Heights Capital Management, Inc.<br>101 California Street, Suite 3250<br>San Francisco, CA 94111<br>United States of America

[*Closing Date*]

To whom it may concern,

**Nyxoah SA (the "Issuer")**

 **€-denominated Amortising Senior Unsecured Convertible Bonds**

I hereby certify that attached hereto is a true and up-to-date copy of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the deed of incorporation and the latest coordinated version of the articles of association of the Issuer;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) an extract from the Crossroads Bank for Enterprises (*Kruispuntbank van Ondernemingen/Banque-Carrefour des Entreprises*); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) an online search on the website of the Central Solvency Register (*Centraal Register Solvabiliteit/Registre Central de la Solvabilité*),

in each case, not being older than one Business Day prior to the date hereof;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) the resolutions of the general meetings of the shareholders of the Issuer authorising the board of directors of the Issuer to issue new Shares;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) a resolution of the board of directors of the Issuer:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) approving and ratifying the execution of the [First Tranche]/[Second Tranche] Bond Documents, the issue of the [First Tranche]/[Second Tranche] Bonds and the consummation of the transactions contemplated by the [First Tranche]/[Second Tranche] Bond Documents and the Equity Offering;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) authorising a specified person or persons to execute the [First Tranche]/[Second Tranche] Bond Documents to which it is a party on its behalf; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) authorising a specified person or persons, on its behalf, to sign and/or despatch all documents and notices to be signed and/or despatched by it under or in connection with the [First Tranche]/[Second Tranche] Bond Documents to which it is a party;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) the certified reports of the Issuer's board of directors and statutory auditor related to the issue of the [First Tranche]/[Second Tranche] Bonds;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) [the nihil obstat letter from the Belgian Financial Services and Markets Authority related to the above reports;]<sup>4</sup>

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) the specimen of the signature of each person authorised by the resolution referred to in paragraph (ii) above; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) the [First Tranche]/[Second Tranche] Register.

Terms used herein and defined in the Subscription Agreement between the Issuer and CVI Investments, Inc. dated 13 November 2025 (as amended or supplemented from time to time) are used herein as so defined.

Yours faithfully,

---

| |
|:---|
| *duly authorised* |
| for and on behalf of |
| **NYXOAH SA** |

---

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<sup>4</sup> *Delete if not applicable and include equivalent certification in the Closing Certificate.*

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**Schedule 5**

**Form of Closing Certificate**

[*Letterhead of the Issuer*]

**Closing Certificate**

**CVI Investments, Inc.**<br>c/o Heights Capital Management, Inc.<br>101 California Street, Suite 3250<br>San Francisco, CA 94111<br>United States of America

[*Closing Date*]

To whom it may concern,

**Nyxoah SA (the "Issuer")**

 **€-denominated Amortising Senior Unsecured Convertible Bonds**

In accordance with the Subscription Agreement between the Issuer and CVI Investments, Inc. dated 13 November 2025 (as amended or supplemented from time to time, the "**Subscription Agreement**"), the undersigned, being a duly authorised officer of the Issuer, hereby certifies that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the representations and warranties of the Issuer in the Subscription Agreement are true, accurate and correct at, and as if made on, the date hereof;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the Issuer has in all material respects performed all of its obligations under the Subscription Agreement to be performed on or before the date hereof;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) there has been no material breach of any of the obligations of the Issuer under the Subscription Agreement;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) as at the date of this certificate, no Default is continuing or would result from the issue of the [First Tranche]/[Second Tranche] Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) there has been no Material Adverse Change;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) [no comments were raised by the Belgian Financial Services and Markets Authority in connection with the reports of the Issuer's board of directors and statutory auditor relating to the issue of the [First Tranche]/[Second Tranche] Bonds;]<sup>5</sup> and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) the terms of the finance contract dated 3 July 2024 and the synthetic warrant agreement dated 15 July 2024 between the Issuer and the European Investment Bank in each case do not include any restrictions, prohibitions or other limitations that would impede or otherwise adversely affect the Issuer's ability to make payments under the [First Tranche]/[Second Tranche] Bonds in cash.

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<sup>5</sup> *Delete if not applicable.*

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

Terms used herein and defined in the Subscription Agreement are used herein as so defined.

Yours faithfully,

---

| |
|:---|
| *duly authorised* |
| for and on behalf of |
| **NYXOAH SA** |

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## Exhibit 4.22

**Exhibit 4.22**

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

EXECUTION VERSION

![Graphic](nyxh-20251231xex4d22001.jpg)

**Dated 18 December 2025**

**Bond Instrument**

constituting the issue of €22,500,000 Amortising Senior Unsecured Convertible Bonds due 2028

by

**Nyxoah SA**<br> as Issuer

White & Case LLP<br>5 Old Broad Street<br>London EC2N 1DW

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**Table of Contents**

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| | | | |
|:---|:---|:---|:---|
|  |  |  | **Page** |
| 1.  | Definitions and Interpretation | Definitions and Interpretation | 1 |
| 2.  | The Bonds | The Bonds | 3 |
| 3.  | Benefit of this Deed | Benefit of this Deed | 3 |
| 4.  | Register and Title | Register and Title | 3 |
| 5.  | Undertakings of the Issuer | Undertakings of the Issuer | 5 |
| 6.  | Transfers of Rights and Obligations | Transfers of Rights and Obligations | 7 |
| 7.  | Amendments and Waivers | Amendments and Waivers | 8 |
| 8.  | Remedies and Waivers | Remedies and Waivers | 8 |
| 9.  | Notices | Notices | 8 |
| 10.  | Severability | Severability | 9 |
| 11.  | Counterparts | Counterparts | 9 |
| 12.  | Governing Law and Jurisdiction | Governing Law and Jurisdiction | 9 |
| **Schedule 1**  | **Schedule 1**  | **Form of Bond Certificate** | **11** |
| **Schedule 2**  | **Schedule 2**  | **Terms and Conditions of the Bonds** | **13** |
| **Schedule 3**  | **Schedule 3**  | **Form of Register** | **91** |
| **Schedule 4**  | **Schedule 4**  | **Regulations Concerning Transfers and Registration of the Bonds** | **92** |
| **Schedule 5**  | **Schedule 5**  | **Form of Officer's Certificate** | **94** |
| **Schedule 6**  | **Schedule 6**  | **Form of Conversion Notice** | **95** |
| **Schedule 7**  | **Schedule 7**  | **Form of Amortised Payment Advancement Notice and Deferral Notice** | **97** |
| **Schedule 8**  | **Schedule 8**  | **Form of Scheduled Amortised Payment Notice** | **99** |
| **Schedule 9**  | **Schedule 9**  | **Form of Tax Status Certificate** | **100** |

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**This Deed** is made on 18 December 2025

**By:**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) **NYXOAH SA**, a public limited liability company incorporated and existing under the laws of Belgium whose registered office is at Rue Edouard Belin, 12, 1435 Mont-Saint-Guibert, Belgium, registered with the Crossroads Bank for Enterprises (Kruispuntbank van Ondernemingen/Banque-Carrefour des Entreprises) under number 0817149675 (Register of Legal Entities Brabant Wallon) (the "**Issuer** "),

**In favour of**:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) **THE PERSONS** for the time being and from time to time registered as holders of the Bonds referred to below (the "**Bondholders**" or "**holders** "),

(each a "**Party**" and together the "**Parties**").

**Whereas:**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) The Issuer shall create and issue, within the framework of the authorised capital granted to its board of directors, Amortising Senior Unsecured Convertible Bonds due 2028 in an aggregate principal amount of €22,500,000 (the "**Bonds** "), and are subject to the terms and conditions of the Bonds set out in Schedule 2 (*Terms and Conditions of the Bonds*) (the "**Conditions** ").

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) Subject to the provisions of the Conditions, the Bonds will be convertible into ordinary shares of the Issuer (the "**Shares**") at the Conversion Price (as defined in the Conditions), subject to adjustment in accordance with the Conditions.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(C) The Bonds will be issued in initial principal amounts of €100,000 each. A certificate representing the Bonds in substantially the form set out in Schedule 1 (*Form of Bond Certificate*) (a "**Bond Certificate**") will be issued to each holder of the Bonds in respect of its registered holding.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(D) The Issuer wishes to constitute the Bonds by this Deed.

**It is agreed** as follows:

**1.** **Definitions and Interpretation**

**1.1** **Definitions**

In this Deed, the following terms shall have the following meanings, and terms used and not defined in this Clause 1.1, and which are defined in the Conditions, shall have the meanings given in the Conditions:

"**€**" or "**EUR**" means the euro currency introduced at the start of the third stage of European economic and monetary union, and as defined in Article 2 of Council Regulation (EC) No 974/98 of 3 May 1998 on the introduction of the euro, as amended.

"**affiliate**" has the meaning given to it in Rule 501(b) of Regulation D under the Securities Act.

"**Bond Certificates**" has the meaning given to it in Recital (C) and includes any replacement Bond Certificate issued pursuant to Clause 4.6 (*Replacement of Bond Certificates*).

"**Bond Documents**" means this Deed (including the Conditions), the Calculation Agency Agreement and each Bond Certificate.

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"**Bonds**" has the meaning given to it in Recital (A)

"**Business Day**" means a day (other than a Saturday or Sunday) on which banks are open for general business in Brussels and New York.

"**Calculation Agency Agreement**" means the calculation agency agreement entered into on the date hereof between the Issuer and the Calculation Agent.

"**Calculation Agent**" means Conv-Ex Advisors Limited.

"**Conditions**" has the meaning given in Recital (A) and any reference to a particular numbered Condition shall be construed accordingly.

"**Conversion Notice**" means a conversion notice in or substantially in the form set out in Schedule 6 (*Form of Conversion Notice*) of this Deed.

"**Existing Holder**" has the meaning given to it in Clause 6.2(a) (*Permitted Transfers*).

"**Governmental Authority**" means the government of any nation, or of any political subdivision thereof, whether state, regional or local, and any agency, authority, branch, department, regulatory body, court, central bank or other entity exercising executive, legislative, judicial, taxing, regulatory or administrative powers or functions of or pertaining to government or any subdivision thereof (including any supra-national bodies).

"**Register**" means the register of Bonds maintained by or on behalf of the Issuer in or substantially in the form set out in Schedule 3 (*Form of Register*) which may be maintained in electronic form.

"**Regulation S**" means Regulation S under the Securities Act.

"**Securities Act**" means the United States Securities Act of 1933, as amended.

"**Shares**" has the meaning given to it in Recital (B).

"**Subsidiary**" means, in relation to any Person (the "**first Person**") at any particular time, any other Person (the "**second Person**") (i) whose affairs and policies the first Person controls or has the power to control, whether by ownership of share capital, contract, the power to appoint or remove members of the governing body of the second person or otherwise or (ii) whose assets, liabilities, equity, income, expenses and cash flows are, in accordance with applicable law and the International Standards on Auditing issued by the International Federation of Accountants (as amended, supplemented or re-issued from time to time), consolidated with those of the first Person in the consolidated financial statements of such Person.

**1.2** **Interpretation**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Unless a contrary indication appears, any reference in this Deed to:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) any "**Bondholder**" or any "**Party**" shall be construed so as to include its successors in title, permitted assigns and permitted transferees to, or of, its rights and/or obligations under the Bond Documents and the Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) "**assets**" includes present and future properties, revenues and rights of every description;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) a "**Bond Document**" or any other agreement or instrument is a reference to that Bond Document or other agreement or instrument as amended, novated, supplemented, extended or restated;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) a "**person**" includes any individual, firm, company, corporation, government, state or agency of a state or any association, trust, joint venture, consortium, partnership or other entity (whether or not having separate legal personality);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) a "**regulation**" includes any regulation, rule, official directive, or official guidance of any governmental, intergovernmental or supranational body, agency, department or of any regulatory, self-regulatory or other Governmental Authority;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) a provision of law is a reference to that provision as amended or re-enacted from time to time; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) a time of day is a reference to Brussels time.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Headings and the table of contents are for ease of reference only and shall not affect the construction of this Deed.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Any reference in this Deed to a Clause or a Schedule is, unless otherwise stated, to a Clause or a Schedule hereof. The Schedules form an integral part of this Deed.

**2.** **The Bonds**

**2.1** **Amount of the Bonds**

The aggregate principal amount of the Bonds on issue shall be €22,500,000. The Bonds shall be issued in principal amounts of €100,000 each.

**2.2** **Covenant to Pay**

On and from the date hereof, the Issuer constitutes the Bonds and covenants in favour of each Bondholder that it will duly perform and comply with the obligations expressed to be undertaken by it in this Deed, in each Bond Certificate and in the Conditions (and for this purpose any reference in the Conditions to any obligation or payment under or in respect of the Bonds shall be construed to include a reference to any obligation or payment under or pursuant to this provision).

**3.** **Benefit of this Deed**

**3.1** **Deed Poll**

This Deed shall take effect as a deed poll for the benefit of the Bondholders from time to time.

**3.2** **Benefit**

This Deed shall ensure to the benefit of the Bondholders and each of their (and any subsequent) successors and assigns, each of which shall be entitled severally to enforce this Deed against the Issuer.

**4.** **Register and Title**

**4.1** **Registration of Bonds**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) The Issuer shall maintain a Register (or shall procure that a Register is maintained on its behalf) in respect of the Bonds in accordance with the regulations in Schedule 4 (*Regulations Concerning Transfers and Registration of the Bonds*).

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) A Bond Certificate will be issued to each Bondholder in respect of its registered holding.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Each Bond Certificate will be numbered serially with an identifying number which will be recorded in the Register by or on behalf of the Issuer.

**4.2** **Title**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Each Bondholder registered in the Register shall (except as otherwise required by law or as ordered by a court of competent jurisdiction) be treated as the absolute owner of such Bond for all purposes (whether or not it is overdue and regardless of any notice of ownership, trust or any other interest in such Bond, any writing on the Bond Certificate relating to such Bonds (other than a duly executed transfer thereof) or any notice of any previous loss or theft of such Bond Certificate) and no person shall be liable for so treating such Bondholder.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) In the event of a transfer completed in accordance with Clause 6 (*Transfers of Rights and Obligations*), the transferor of a Bond shall be treated as the holder of the relevant Bond for the purposes of payment on the Interest Payment Date on which such transfer took place.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) The Issuer shall promptly on demand by any Bondholder (and in any event by no later than five Business Days after demand) send to such Bondholder an extract of the Register evidencing such Bondholder as the registered holder of the Bonds held by it at such time.

**4.3** **Registration and Delivery of Bond Certificates**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Promptly following the surrender of a Bond Certificate in respect of a transfer of Bonds in accordance with Clause 6 (*Transfers of Rights and Obligations*) and Schedule 4 (*Regulations Concerning Transfers and Registration of the Bonds*), the Issuer will register the transfer in question and deliver, or procure the registration of, the New Holder in the Register and deliver, at the Issuer's expense (except as provided below), a new Bond Certificate in a principal amount equal to the amount of Bonds transferred to such New Holder at the address specified for the purpose by such New Holder and, if applicable, a new Bond Certificate to the Existing Holders in accordance with Clause 6 (*Transfers of Rights and Obligations*).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Promptly following the exercise by any Bondholder of its Conversion Rights and surrender of a Bond Certificate in accordance with Condition 6.9 (*Procedure for exercise of Conversion Rights*), the Issuer will register, or procure the registration of, such conversion of the Bonds in the Register.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Solely in the case of a partial conversion of Bonds in accordance with the Conditions, the Issuer shall deliver, at its own expense (except as provided below) a new Bond Certificate to such Bondholder representing the principal amount of Bonds held thereby following such partial conversion.

**4.4** **Closed Periods**

Without prejudice to any of the other transfer restrictions that apply to the Bonds provided for in any Bond Documents, the Bondholders may not transfer any Bond(s) (a) during the period of three Brussels business days ending on the due date for any payment of principal or interest in respect of the Bonds, or (b) in respect of which a Conversion Notice has been delivered in accordance with the Conditions.

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**4.5** **Regulations Concerning Transfers and Registration**

All transfers of Bonds, provision of new Bond Certificates (upon transfer) and entries on the Register are subject to the detailed regulations concerning the transfer and registration of Bonds set out in Schedule 4 (*Regulations Concerning Transfers and Registration of the Bonds*) and any other transfer restriction provided for in any Bond Documents.

**4.6** **Replacement of Bond Certificates**

Promptly following receipt by the Issuer of evidence reasonably satisfactory to it of the ownership of and the loss, theft, destruction or mutilation of any Bond Certificate, and:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)in the case of loss, theft or destruction, of an indemnity reasonably satisfactory to it; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)in the case of mutilation, upon surrender and cancellation of such Bond Certificate,

the Issuer shall, at its own expense, execute and deliver, a replacement Bond Certificate.

**4.7** **Copies of Bond Certificates**

Whenever in this Deed or the Conditions there is any requirement to deliver, produce, surrender or possess a Bond Certificate, the delivery, production, surrender or possession of an electronic copy of such Bond Certificate shall be satisfactory, save that, in the case of a surrender of a Bond Certificate by electronic means the Bondholder shall confirm to the Issuer destruction of any original thereof.

**5.** **Undertakings of the Issuer**

**5.1** **Compliance**

The Issuer undertakes to the Bondholders that it shall comply with the provisions of all Bond Certificates and this Deed (including the Conditions) and the Bonds shall be held subject to and with the benefit of such provisions and the relevant Conditions.

**5.2** **Register**

The Issuer shall, at its own cost, promptly on demand by any Bondholder (and in any event by no later than three Business Days after demand) send to such Bondholder a complete and correct copy of its entry in the Register (including by email, if so requested by any such Bondholder).

**5.3** **Amendment Costs**

If the Issuer requests an amendment, waiver or consent and such requests for amendments, waivers or consents, in the opinion of the Majority Bondholders, require external legal fees to be incurred, the Issuer shall, within five Business Days of demand, reimburse each Bondholder for the reasonable amount of such external legal costs and expenses properly incurred by it in responding to, evaluating, negotiating or complying with that request or requirement.

**5.4** **Enforcement Costs**

The Issuer shall, within five Business Days of demand, pay to each Bondholder the amount of all costs and expenses (including reasonable external legal fees) incurred by that Bondholder in connection with the enforcement of, or the preservation of any rights under, the Bonds and this Deed.

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**5.5** **Tax Compliance**

The Issuer shall, within five Business Days of demand, pay to each Bondholder the amount of all costs and expenses (including reasonable external legal fees) incurred by that Bondholder in connection with its preparation and delivery of any forms, certificates or other documents to be signed or the taking of any other step or action, in each case in accordance with Condition 8 (*Taxation*).

**5.6** **Stamp Duties and Other Taxes**

The Issuer shall pay any stamp, issue, documentary or other taxes and duties, including interest and penalties, payable in respect of the creation, issue and offering of the Bonds and the execution of the Bond Documents. The Issuer shall also indemnify the Bondholders from and against all stamp, issue, documentary or other taxes paid by any of them in any jurisdiction in connection with any action taken by or on behalf of the Bondholders to enforce the Issuer's obligations under the Bond Documents or the Bonds.

**5.7** **Payments**

All payments in respect of the obligations of the Issuer under this Deed shall be made free and clear of, and without withholding or deduction for or on account of, any taxes, duties, assessments or governmental charges of whatever nature imposed, levied, collected, withheld or assessed by or on behalf of Belgium or any political subdivision or any authority thereof or therein having power to tax, unless such withholding or deduction is required by law. In that event, the Issuer shall pay such additional amounts as will result in the receipt by the Bondholders of such amounts as would have been received by it if no such withholding or deduction had been required. This Clause 5.7 shall not apply in respect of the payment obligations of the Issuer in respect of the Bonds under the Conditions (but without prejudice to the terms and condition set out in the Conditions).

**5.8** **Currency Indemnity**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) If any sum due from the Issuer under the Bond Documents (a "**Sum** "), or any order, judgment or award given or made in relation to a Sum, has to be converted from the currency (the "**First Currency**") in which that Sum is payable into another currency (the "**Second Currency**") for the purpose of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) making or filing a claim or proof against the Issuer; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) obtaining or enforcing an order, judgment or award in relation to any litigation or arbitration proceedings,

the Issuer shall as an independent obligation, within five Business Days of demand, indemnify the Bondholders to whom that Sum is due against any cost, loss or liability arising out of or as a result of the conversion, including any discrepancy between (A) the rate of exchange used to convert that Sum from the First Currency into the Second Currency and (B) the rate or rates of exchange available to that person at the time of its receipt of that Sum.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) The Issuer waives any right it may have in any jurisdiction to pay any amount under any of the Bond Documents in a currency or currency unit other than that in which it is expressed to be payable.

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**5.9** **Other Indemnities**

The Issuer shall, within five Business Days of demand, indemnify the Bondholders against any cost, loss or liability properly incurred by the Bondholders (acting reasonably) as a result of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) investigating any event which it reasonably believes is a Default; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) acting or relying on any notice, request or instruction which it reasonably believes to be genuine, correct and appropriately authorised.

**6.** **Transfers of Rights and Obligations**

**6.1** **Assignment and Transfers**

Except as set out below in Clause 6.2 (*Permitted Transfers*), no Party may assign or transfer its rights, benefits and obligations under this Deed (including the Conditions) or any Bond.

**6.2** **Permitted Transfers**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Subject to Clauses 4.4 (*Closed Periods*), 4.5 (*Regulations Concerning Transfers and Registration*) and the other provisions of this Clause 6.2, a Bondholder (being an "**Existing Holder**") may at any time transfer a Bond or Bonds to any person (a "**New Holder** "), *provided that*:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the aggregate principal amount of such Bond or Bonds transferred is in a principal amount of not less than €100,000 or a whole number multiple thereof;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the transfer shall only become effective at midnight (Brussels time) on an Interest Payment Date (it being understood that the Issuer shall recognise and register the transfer as having occurred at that time);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) the Issuer having received by no later than the 15<sup>th</sup> day immediately preceding the Interest Payment Date on which such transfer is expected to become effective, either:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) a copy of the agreement or other transfer documentation entered into between the transferor and the transferee to effect the transfer of such Bond, executed by both such parties and setting forth that the transfer of ownership shall become effective at midnight on the Interest Payment Date following the date of such agreement and that the transferor shall remain entitled to interest and other payments due on such Bond until such time; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) if, for whatever reason, the Existing Holder cannot furnish or otherwise disclose the agreement or other documentation specified in paragraph (1) above, a copy of written correspondence between and signed by each of the Existing Holder and the New Holder identifying the details of their entry into such agreement or other documentation;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) the Bond or Bonds are being transferred in a transaction exempt from, or not subject to, the registration requirements of the Securities Act, and in each case in compliance with applicable securities laws; and

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) the Existing Holder surrenders (which may be by email of a copy) its Bond Certificate to the Issuer for destruction or (in the case of a partial transfer) replacement in accordance with this Deed.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) A Bondholder may not transfer a Bond to a person who (i) is a retail client as defined in point (6) of Article 4(1) of Regulation (EU) 1286/2014/EU or (ii) is not a qualified investor as defined in Regulation (EU) 2017/1129 of the European Parliament and of the Council.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Notwithstanding the foregoing, a Bondholder may not transfer a Bond during the 40 day "distribution compliance period" (as defined in Regulation S (the "**Distribution Compliance Period** "), and the Bonds may only be offered or sold, prior to the expiration of the Distribution Compliance Period, (i) in accordance with Rule 903 or 904 of Regulation S, (ii) pursuant to registration of the Bonds under the Securities Act, or (iii) pursuant to an available exemption from, or in a transaction not subject to, the registration requirements of the Securities Act.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) Following the surrender of the relevant Bond Certificate and the transfer of any Bonds in accordance with this Clause 6.2 (*Permitted Transfers*), the Issuer will (subject to and in accordance with the requirements of Schedule 4 (*Regulations Concerning Transfers and Registration of the Bonds*)) on the effective transfer date promptly register the transfer in the Register and issue a copy of the updated Register to the New Holder and (solely in the case of a partial transfer) the relevant Existing Holder.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) Such transfer of Bonds will be effected without charge, subject to the person making such application for transfer paying or procuring the payment of any taxes, duties and other governmental charges in connection therewith.

**7.** **Amendments and Waivers**

The provisions of this Deed (including the Conditions) may not be modified, altered, abrogated or added to other than as provided in, and in accordance with, Condition 15 (*Amendment and Waiver*).

**8.** **Remedies and Waivers**

No failure to exercise, and no delay in exercising, on the part of the Bondholders of any right hereunder shall operate as a waiver thereof nor shall any single or partial exercise thereof preclude any other or future exercise thereof or the exercise of any other right. Rights hereunder shall be in addition to all other rights provided by law. No notice or demand given in any case shall constitute a waiver of rights to take other action in the same, similar or other instances without such notice or demand.

**9.** **Notices**

**9.1** **Communications in Writing**

Any communication to be made under or in connection with this Deed or the Bonds shall be made in writing and, unless otherwise stated, may be made by email or letter.

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**9.2** **Addresses**

The address and email address (and the department or officer, if any, for whose attention the communication is to be made) of the Issuer for any communication or document to be made or delivered under or in connection with this Deed or the Bonds is:

Address: [\*\*\*]

Email: [\*\*\*]

Attention: [\*\*\*]

or any substitute address or email address or department or officer as the Issuer may notify to the Bondholders by not less than five Business Days' notice.

**9.3** **Effectiveness**

Any notice given under this Deed shall take effect, in the case of a letter, at the time of delivery, or in the case of email transmission, at the time of despatch (unless a delivery failure notification is received by the sender within 12 hours of sending such communication, in which case such notice shall be deemed not to have taken effect). If such delivery or despatch is made after 5:00 p.m. (Brussels time) or on a day which is not a Brussels business day (in respect of matters where only Brussels business days are specified) or Business Day (in respect of all other matters), such delivery shall be deemed to have been made on the next following Brussels business day or Business Day, as applicable.

**10.** **Severability**

If any provision in or obligation under this Deed is or becomes invalid, illegal or unenforceable in any respect under the law of any jurisdiction, that will not affect or impair (a) the validity, legality or enforceability under the law of that jurisdiction of any other provision in or obligation under this Deed, and (b) the validity, legality or enforceability under the law of any other jurisdiction of that or any other provision in or obligation under this Deed.

**11.** **Counterparts**

This Deed may be executed in any number of counterparts, and this has the same effect as if the signatures on the counterparts were on a single copy of this Deed.

**12.** **Governing Law and Jurisdiction**

**12.1** **Governing Law**

This Deed, including any non-contractual obligations arising out of or in connection with this Deed, are governed by, and shall be construed in accordance with, English law, except that the provisions relating to ranking, status and subordination in Condition 1.3 (*Status*) and Condition 1.4 (*Subordination*) and the rights and obligations of the Issuer and the Bondholders in respect thereof, shall be governed by and construed in accordance with the laws of Belgium.

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**12.2** **Jurisdiction**

The Issuer agrees for the benefit of each Bondholder that the courts of England shall have exclusive jurisdiction to hear and determine any suit, action or proceedings arising out of or in connection with this Deed (including any non-contractual obligations arising out of or in connection with this Deed) ("**Proceedings**") and, for such purposes, irrevocably submits to the jurisdiction of such courts. Nothing in this paragraph shall (or shall be construed so as to) limit the right of any Bondholder to take Proceedings in any other court of competent jurisdiction, nor shall the taking of Proceedings in any one or more jurisdictions preclude the taking of Proceedings by any Bondholder in any other jurisdiction (whether concurrently or not) if and to the extent permitted by law.

**12.3** **Appropriate Forum**

For the purpose of Clause 12.2 (*Jurisdiction*), the Issuer irrevocably waives any objection which it might now or hereafter have to the courts of England being nominated as the forum to hear and determine any Proceedings and agrees not to claim that any such court is not a convenient or appropriate forum.

**12.4** **Service of Process**

The Issuer agrees that the process by which any Proceedings are commenced in England pursuant to Clause 12.2 (*Jurisdiction*) may be served on it by being delivered to the attention of Law Debenture Corporate Services Limited at its registered office from time to time. If such person is not or ceases to be effectively appointed to accept service of process on behalf of the Issuer, the Issuer shall promptly appoint a further person in England to accept service of process on its behalf. Nothing in this paragraph shall affect the right of any Bondholder to serve process in any other manner permitted by law.

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**Schedule 1** 

**Form of Bond Certificate**

---

| | |
|:---|:---|
| Bond Certificate No. [**●**] | €[*amount*] |

---

**Nyxoah SA (the "Issuer")**

(*a public limited liability company incorporated and existing under the laws of Belgium*)

**€22,500,000 Amortising Senior Unsecured Convertible Bonds due [●]**

This certificate (the "**Bond Certificate**") is issued by the Issuer to [**●**] as the registered holder of €[**●**] in principal amount of the €22,500,000 Amortising Senior Unsecured Convertible Bonds due 2028 (the "**Bonds**") issued with the benefit of and subject to the provisions contained in the Bond Instrument relating to the Bonds dated 18 December 2025 and made by the Issuer (as amended, supplemented or amended and restated from time to time, the "**Bond Instrument**"). Words and expressions defined in the Bond Instrument shall, unless the context otherwise requires, have the same meanings in this Bond Certificate.

Interest is payable on the Bonds in accordance with Condition 5 (*Interest*). The Bonds are redeemable in accordance with Condition 6 (*Conversion of Bonds*) and Condition 7 (*Redemption of Bonds*).

Title to the Bonds passes only on due registration on the Register, and any payment due on the Bond whether of principal, interest or premium (if any) will be made only to the duly registered holder. The Bonds are transferable only in denominations of €100,000. This Bond Certificate must be lodged together with the instrument of transfer (which must be signed by the transferor or by a person authorised to sign on behalf of the transferor) at the registered office of the Issuer. This Bond Certificate must be surrendered (which may be by email of a copy) before any transfer can be registered or any new Bond Certificate issued in exchange.

**THE BONDS HAVE NOT BEEN AND WILL NOT BE REGISTERED UNDER THE SECURITIES ACT OR ANY SECURITIES LAW OF ANY STATE OF THE UNITED STATES AND MAY NOT BE OFFERED OR SOLD IN OR INTO THE UNITED STATES OR TO US PERSONS, EXCEPT PURUSANT TO AN EFFECTIVE REGISTRATION STATEMENT OR IN TRANSACTIONS EXEMPT FROM, OR NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT OR SUCH OTHER SECURITIES LAW, OR IN OR INTO ANY OTHER RESTRICTED JURISDICTION, NOR TO OR FOR THE ACCOUNT OR BENEFIT OF ANY RESTRICTED OVERSEAS PERSON.**

This Bond Certificate is evidence of entitlement only and is not a document of title. Entitlements are determined by the Register and only the Holder is entitled to payment in respect of this Bond Certificate. This Bond Certificate and any non-contractual obligations arising out of or in connection with it shall be governed by, and construed in accordance with, English law.

---

| |
|:---|
| *duly authorised*  |
| for and on behalf of |
| **NYXOAH SA** |
| Issued on [**●**] 20[**●**] |

---

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**FORM OF TRANSFER**

**Nyxoah SA (the "Issuer")**

(*a public limited liability company incorporated and existing under the laws of Belgium*)

**€22,500,000 Amortising Senior Unsecured Convertible Bonds due 2028 (the "Bonds")**

Dated: [●]

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. For value received [ *insert name of transferor* ] (the "**Transferor** "), being the registered holder of this Bond Certificate, hereby transfers to [ *insert name of transferee* ] (the "**Transferee** "), €[●]<sup>1</sup> in principal amount of the Bonds of the Issuer and irrevocably requests and authorises the Issuer to effect the relevant transfer by means of appropriate entries in the register kept by it.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. The administrative details of the Transferee for the purpose of the Bonds are:

[*Insert Address*]

[*Attention*]

[*Email*]

[*Payment Details*]

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3. The Transferee expressly acknowledges the limitations on the Transferor's obligations in respect of this Bond Certificate, the Bond Instrument and the Conditions.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4. This transfer certificate may be entered into in any number of counterparts and this has the same effect as if the signature on the counterparts were on a single copy of the transfer certificate.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5. This transfer certificate and any non-contractual obligations arising out of or in connection with it are governed by and construed in accordance with English law.

[***INSERT APPROPRIATE EXECUTION BLOCK***]

**Notes**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) The name of the person by or on whose behalf this form of transfer is signed must correspond with the name of the registered holder as it appears on the face of this Bond Certificate.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) A representative of such registered holder should state the capacity in which he signs, e.g., executor.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) This form of transfer must be accompanied by such documents, evidence or information as the Issuer may reasonably require.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) If the Transferor is a corporation, partnership or fiduciary, the title of the person signing on behalf of such Transferor must be stated.

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<sup>1</sup> *Note to Transferor: Bonds are transferable only in denominations of €100,000.*

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**Schedule 2** 

**Terms and Conditions of the Bonds**

The issue of the €22,500,000 Amortising Senior Convertible Bonds due 2028 (the "**Bonds**", which expression shall, unless otherwise indicated, include any Further Bonds (as defined below)) was (save in respect of any Further Bonds) effected within the framework of the authorised capital granted by the board of directors of Nyxoah SA (the "**Issuer**") on or around 18 December 2025.

The Bonds are constituted by a Bond Instrument dated 18 December 2025 (as amended, supplemented or amended and restated from time to time, the "**Bond Instrument**") made by the Issuer. The statements set out in these Terms and Conditions (the "**Conditions**") are subject to the provisions of the Bond Instrument.

The Issuer has also entered into a calculation agency agreement (as amended, supplemented or amended and restated from time to time, the "**Calculation Agency Agreement**") dated 18 December 2025 with Conv-Ex Advisors Limited (the "**Calculation Agent**", which expression shall include any successor as calculation agent under the Calculation Agency Agreement) pursuant to which the Calculation Agent will be appointed to make certain calculations in relation to the Bonds. The Bondholders are deemed to have notice of those provisions applicable to them which are contained in the Calculation Agency Agreement.

Capitalised terms used but not defined in these Conditions shall have the meanings attributed to them in the Bond Instrument unless the context otherwise requires or unless otherwise stated.

**1.** **Form, Initial Denomination, Title and Status**

**1.1** **Form and Initial Denomination**

The Bonds are in registered form in initial principal amounts of €100,000 each, as may be reduced from time to time in accordance with Condition 7.1 (*Mandatory Redemption by Amortisation*).

**1.2** **Title**

Title to the Bonds will pass by transfer and registration as described in Clause 4 (*Register and Title*) and Clause 6 (*Transfers of Rights and Obligations*) of the Bond Instrument and Condition 4 (*Registration and Transfer of Bonds*). Each holder of Bonds will (except as otherwise required by law or as ordered by a court of competent jurisdiction) be treated as the absolute owner of such Bond for all purposes (whether or not it is overdue and regardless of any notice of ownership, trust or any interest in such Bond, any writing on the Bond Certificate relating to such Bonds or any notice of any previous loss or theft of such Bond Certificate) and no person will be liable for so treating such holder.

**1.3** **Status**

The Bonds constitute direct, unconditional, (subject to Condition 1.4 (*Subordination*)) unsubordinated and (subject to Condition 2.1 (*Negative Pledge*)) unsecured obligations of the Issuer ranking *pari passu* and rateably, without any preference among themselves, and at least equally with all other existing and future unsecured and unsubordinated obligations of the Issuer but, in the event of an insolvency of the Issuer, save for such obligations that may be preferred by provisions of law that are mandatory and of general application.

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**1.4** **Subordination**

The Bonds shall rank in right and priority of payment immediately after the Issuer's liabilities under the EIB Facility and are postponed and subordinated solely to the Issuer's liabilities under the EIB Facility, except for any obligations mandatorily preferred by law applying to companies generally.

The Bonds shall not be, and are not intended to be, subordinated to any present or future indebtedness, obligations or liabilities of the Issuer, whether senior, *pari passu*, or otherwise, other than the liabilities under the EIB Facility, except for obligations mandatorily preferred by law applying to companies generally.

The Bonds shall rank at least *pari passu* with all other present and future unsecured and unsubordinated liabilities of the Issuer's, except for obligations mandatorily preferred by law applying to companies generally.

**2.** **Covenants**

**2.1** **Negative Pledge**

So long as any Bond remains outstanding (as defined below), the Issuer shall not, and will procure that none of its Subsidiaries will, create or permit to subsist any Security Interest (as defined below) upon the whole or any part of its present or future undertaking, assets or revenues (including any uncalled capital) to secure any Financial Indebtedness or to secure any Financial Indebtedness Guarantee, without at the same time or prior thereto:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) securing the obligations of the Issuer under the Bonds and the Bond Instrument (including these Conditions) equally and rateably therewith; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) providing such other security, guarantees and/or other arrangements (whether or not comprising a Security Interest) for the benefit of Bondholders as may be approved by holders of at least 90 per cent. in principal amount of the Bonds then outstanding,

*provided that:*

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) any entity acquired by the Issuer after the Issue Date may have outstanding Security Interests with respect to Financial Indebtedness and/or any Financial Indebtedness Guarantee or indemnity in respect of such Financial Indebtedness of such entity, so long as any such Security Interest was outstanding on the date on which any such entity became a Subsidiary of the Issuer and was not created in contemplation of any such entity becoming a Subsidiary of the Issuer, or any such Security Interest was created in substitution for or to replace either any such outstanding Security Interest or any such substituted or replacement Security Interest and is not increased in amount after the date that any such entity became a Subsidiary of the Issuer;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) any entity which becomes a Subsidiary of the Issuer or is merged, consolidated or amalgamated into a Subsidiary of the Issuer on or after the Issue Date may have outstanding Security Interests with respect to Financial Indebtedness and/or any Financial Indebtedness Guarantee or indemnity in respect of such Financial Indebtedness of such Subsidiary, so long as any such Security Interest

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) was outstanding on the date on which any such entity became a Subsidiary of the Issuer or was merged, consolidated or amalgamated into a Subsidiary of the Issuer;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) was not created in contemplation of any such entity becoming a Subsidiary of the Issuer or being merged, consolidated or amalgamated into a Subsidiary of the Issuer; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(C) is not increased in amount after the date that any such entity became a Subsidiary of the Issuer or was merged, consolidated or amalgamated into a Subsidiary of the Issuer; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) the Issuer may have, at any time, any Security Interest to secure any Financial Indebtedness or to secure any Financial Indebtedness Guarantee or indemnity in respect of any Financial Indebtedness to the extent that such Security Interest arises by operation of law.

**2.2** **Incurrence of Financial Indebtedness**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) For so long as any Bond remains outstanding, the Issuer shall not, and shall procure that its Subsidiaries shall not, directly or indirectly and at any time, create, incur, assume or otherwise become liable (contingently or otherwise) in respect of any Financial Indebtedness which by their terms carry (directly or indirectly) rights of conversion into, or exchange or subscription for, or the right to otherwise acquire, any shares in the capital of the Issuer or any of its Subsidiaries.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Condition 2.2(a) (*Incurrence of Financial Indebtedness*) shall not prohibit the incurrence by the Issuer of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) Financial Indebtedness represented by the Bonds, if issued, or the Second Tranche Bonds; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) Financial Indebtedness of the Issuer and its Subsidiaries that is outstanding as at the Issue Date.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) For so long as any Bond remains outstanding,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the Issuer shall not, and shall procure that its Subsidiaries shall not, directly or indirectly and at any time, create, incur, assume or otherwise become liable (contingently or otherwise) in respect of any Financial Indebtedness in any amount which by their terms (directly or indirectly) limit or prohibit any term of the Bonds or the Bond Documents, including, without limitation:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) any prohibition on any payment of cash by the Issuer in respect of any obligation under the Bonds or the Bond Documents;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) any limitation on the ability of the Bondholders to exercise Conversion Rights; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(C) any limitation on the ability of the Issuer to deliver Shares in respect of the exercise of any Share Settlement Option; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the Issuer shall not, and shall procure that its Subsidiaries shall not, directly or indirectly and at any time, create, incur, assume or otherwise become liable (contingently or otherwise) in respect of any Financial Indebtedness in any amount which by their terms (directly or indirectly) would rank senior to the Bonds in right of payment.

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**2.3** **Information and General Undertakings**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) For so long as any Bonds are outstanding, the Issuer shall deliver to each Bondholder:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) within 15 Brussels business days following publication of its financial statements for its full financial year and each quarter of its financial year; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) within 10 Brussels business days following a request in writing by a Bondholder (at any time, acting reasonably, but on no more than two occasions each calendar year),

a certificate in substantially the form set out in Schedule 5 (*Form of Officers' Certificate*) of the Bond Instrument and signed by at least one authorised signatory of the Issuer (being responsible accounting or financial officer or director) certifying:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the details of any Security Interest created over any assets of, the Issuer and/or any of its Subsidiaries, since the date of the last such certificate (or, in the case of the first such certificate, the Issue Date),

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) that the terms of any Financial Indebtedness incurred by the Issuer or any of its Subsidiaries since the date of the last such certificate (or, in the case of the first such certificate, the Issue Date) do not, expressly or impliedly, limit, impair or otherwise restrict the ability of the Issuer to at all times perform and comply with its payment, indemnity and/or any other obligations under these Conditions or the terms of any of the Bond Documents; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) that no Relevant Event has occurred and that no Event of Default or Potential Event of Default has occurred and is continuing since the date of the last such certificate (or, in the case of the first such certificate, the Issue Date) or if such an event has occurred, giving all relevant details of such event.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) For so long as any Bonds are outstanding, the Issuer shall publish as soon as the same become available, but in any event:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) within four calendar months after the end of each of its financial years, commencing with the financial year ended 31 December 2025, the Issuer's audited consolidated financial statements for such financial year, with accompanying notes and prepared in accordance with IFRS accounting principles generally accepted in Belgium consistently applied; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) within three calendar months after the end of each quarterly period for each of its financial years commencing with the three months ended 31 March 2026, the Issuer's unaudited consolidated financial statements for such period, with accompanying notes.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) For so long as any Bond remains outstanding:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the Issuer shall not, and the Issuer shall procure that its Subsidiaries will not, enter into any amalgamation, demerger, merger, consolidation or corporate reconstruction or reorganisation, except:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) in relation to any partnering and/or licensing transactions with third parties for the purposes of developing (including clinical trials), manufacturing,

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marketing or distributing its medical treatments, future products, technologies or intellectual property or otherwise; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) on terms approved by the Majority Bondholders;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the Issuer shall not, and the Issuer shall procure that its Subsidiaries will not, except on terms approved by the Majority Bondholders, enter into a single transaction or a series of transactions (whether related or not) and whether voluntary or involuntary to sell, lease, transfer or otherwise dispose of any asset, other than any sale, lease, transfer or other disposal which is:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) made by the Issuer or any of its Subsidiaries in the ordinary course of trading of the disposing entity;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) made by the Issuer or any of its Subsidiaries in relation to any partnering and/or licensing transactions with third parties, including but not limited to collaborations, joint ventures, or strategic alliances, for the purpose of developing (including clinical trials), manufacturing, marketing, or distributing its medical treatments, future products, technologies, or intellectual property. For the avoidance of doubt, such transactions may include, but are not limited to, the granting of and/or accepting licenses, sublicenses, or other rights to use the patents, trademarks, copyrights, trade secrets, know-how or other proprietary information;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(C) of assets (other than shares, businesses, real property or intellectual property) in exchange for other assets comparable or superior as to type, value and quality;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(D) of obsolete or redundant vehicles, plant and equipment for cash; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(E) the solvent liquidation or reorganisation of any Subsidiary of the Issuer so long as any payments or assets distributed as a result of such liquidation or reorganisation are distributed to the Issuer and/or its Subsidiaries;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) the Issuer shall, and the Issuer shall procure that its Subsidiaries will, comply with all laws and regulations to which they may be subject from time to time, if failure so to comply would impair the Issuer's ability to perform its obligations under the Bonds and the Bond Documents;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) the Issuer shall, and the Issuer shall procure that its Subsidiaries will, ensure that no substantial change is made to the general nature of the business of the Issuer and its Subsidiaries from that carried on as at the Issue Date,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) the Issuer shall, and the Issuer shall procure that its Subsidiaries shall, promptly:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) obtain, comply with and do all that is necessary to maintain in full force and effect; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) upon request by the Majority Bondholders, supply certified copies to the Bondholders of,

any Authorisation required under any law or regulation of its jurisdiction of incorporation to enable it to perform its obligations under the Bonds and the Bond

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Documents and to ensure the legality, validity, enforceability or admissibility in evidence in its jurisdiction of incorporation of the Bonds or any Bond Document;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) the Issuer shall not, and the Issuer shall procure that none of its Subsidiaries will, enter into any transaction with any affiliate(s), unless such transaction is on terms that are not materially less favourable to the Issuer or such Subsidiary, as applicable, than those that could be obtained at the time of such transaction in arm's-length dealings with a person that is not an affiliate;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) the Issuer shall not, and shall procure that its Subsidiaries shall not, at any time, create or otherwise cause or permit to exist or become effective (expressly or impliedly) any consensual encumbrance or restriction on the ability of the Issuer to at all times perform and comply with its payment, indemnity and/or any other obligations under these Conditions or the terms of any of the Bond Documents; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(viii) the Issuer shall not, and shall procure that its Subsidiaries shall not, amend, modify, vary any term of the EIB Facility, or enter into any new agreements, instruments or other arrangements with the European Investment Bank, in each case that could reasonably be expected to impair, restrict, prohibit or limit the Issuer's ability to perform its obligations under the Bonds and the Bond Documents (including, without limitation, its ability to make payments under the Bonds in cash).

**3.** **Definitions**

In these Conditions, unless otherwise provided:

"**€**" or "**EUR**" means the euro currency introduced at the start of the third stage of European economic and monetary union, and as defined in Article 2 of Council Regulation (EC) No 974/98 of 3 May 1998 on the introduction of the euro, as amended.

"**Advanced Amortised Payment Amount**" has the meaning provided in Condition 7.1(c)(i) (*Deferral and Advancement of Amortisation Payments*).

"**Advanced Amortisation Payment Date**" has the meaning provided in Condition 7.1(c)(i) (*Deferral and Advancement of Amortisation Payments*).

"**Additional Shares**" has the meaning provided in Condition 6.3 (*Retroactive Adjustments*).

"**affiliate**" (a) for the purposes of Condition 17 (*Beneficial Ownership of Shares*), has the meaning given to it in Rule 501(b) of Regulation D under the Securities Act, and (b) in all other cases, means a person that directly, or indirectly through one or more intermediaries, Controls or is Controlled by, or is under common Control with, the person specified.

"**Amortisation Conversion Right**" has the meaning provided in Condition 6.1 (Conversion Period and Conversion Price).

"**Amortisation Payment Date**" has the meaning provided in Condition 7.1(a) (*Scheduled Amortisation Payments*).

"**Amortised Payment Advancement**" has the meaning provided in Condition 7.1(c)(ii) (*Deferral and Advancement of Amortisation Payments*).

"**Amortised Payment Advancement Notice**" has the meaning provided in Condition 7.1(c)(ii) (*Deferral and Advancement of Amortisation Payments*).

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"**Amortised Payment Amount**" has the meaning provided in Condition 7.1(a) (*Scheduled Amortisation Payments*).

"**Amortised Payment Deferral**" has the meaning provided in Condition 7.1(c)(i) (*Deferral and Advancement of Amortisation Payments*).

"**Applicable Adjustment Record Date**" means, in respect of any of the events referred to in Conditions 6.2(a) (*Consolidation, reclassification, redesignation or subdivision*) to 6.2(i) (*Certain arrangements*), the record date in respect of any consolidation, reclassification, re-designation or sub-division as is mentioned in Condition 6.2(a) (*Consolidation, reclassification, redesignation or subdivision*) to 6.2(i) (*Certain arrangements*), or which is the record date or other due date for the establishment of entitlement for any such issue, distribution, grant or offer (as the case may be) as is mentioned in Condition 6.2(b) (*Capitalisation of profits or reserves*), 6.2(c) (*Dividends*), 6.2(d) (*Rights issues*), 6.2(e) (*Issue of Securities to Shareholders*) or 6.2(i) (*Certain arrangements*), or which is the date of the first public announcement of the terms of any such issue or grant as is mentioned in Condition 6.2(f) (*Issue of Shares at below Current Market Price*) and 6.2(g) (*Other issues*) or of the terms of any such modification as is mentioned in Condition 6.2(h) (*Modification of rights*).

"**Applicable Adjustment Reference Date**" means, in respect of any of the events referred to in Conditions 6.2(a) (*Consolidation, reclassification, redesignation or subdivision*) to 6.2(i) (*Certain arrangements*), (i) in the case of an adjustment pursuant to Conditions 6.2(a) (*Consolidation, reclassification, redesignation or subdivision*), 6.2(b) (*Capitalisation of profits or reserves*), 6.2(c) (*Dividends*), 6.2(d) (*Rights issues*), 6.2(e) (*Issue of Securities to Shareholders*) or 6.2(i) (*Certain arrangements*), the relevant Ex-Date of the relevant event in respect of which such adjustment is made and (ii) in the case of an adjustment pursuant to Conditions 6.2(f) (*Issue of Shares at below Current Market Price*), 6.2(g) (*Other issues*) or 6.2(h) (*Modification of rights*), the relevant date of the first public announcement as is mentioned in Conditions 6.2(f) (*Issue of Shares at below Current Market Price*), 6.2(g) (*Other issues*) or 6.2(h) (*Modification of rights*), as the case may be.

"**Attribution Parties**" means, in respect of a Bondholder, collectively, the following persons and entities:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) any investment vehicle, including, any funds, feeder funds or managed accounts, currently, or from time to time after the Issue Date, directly or indirectly managed or advised by the Bondholder's investment manager or any of its affiliates or principals;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) any direct or indirect affiliates of the Bondholder or any of the foregoing;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) any person acting or who could be deemed to be acting as a group together with the Bondholder or any of the foregoing; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) any other persons whose beneficial ownership of the Shares would or could be aggregated with the Bondholder's and the other Attribution Parties for purposes of Section 13(d) of the Exchange Act.

"**Authorisation**" means an authorisation, consent, approval, resolution, licence, exemption, filing, notarisation or registration.

"**Belgian/US Share Confirmation**" has the meaning given in Condition 9.9(e)(vii) (*Provisions relating to the Share Settlement Option*).

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"**Belgian Code on Companies and Associations**" means the Belgian Companies and Associations Code (*Wetboek van vennootschappen en verenigingen/Code des sociétés et des associations*), as amended.

"**Belgian Crossroads Bank for Enterprises"** means the Crossroads Bank for Enterprises (*Banque-Carrefour des Entreprises/Kruispuntbank van Ondernemingen*), a public institution established under Belgian law, which manages the central database of business entities registered in Belgium.

"**Belgian Civil Code**" means the Belgian Civil Code (*Burgerlijk Wetboek/Code civil*), as amended from time to time.

"**Belgian Share**" means any Share that is required pursuant to these Conditions to be issued or transferred and delivered in dematerialised form through the securities trading system operated by Euroclear Belgium on exercise of Conversion Rights or the Share Settlement Option.

"**Bloomberg Screen Observation Time**" means, in respect of any dealing day in respect of the Shares, other Securities, Spin-Off Securities, options, warrants, or other rights or assets, such time of observation as is determined by the Calculation Agent in its sole discretion, provided that such Bloomberg Screen Observation Time (i) may not occur prior to the Regular Closing Time (in respect of the Shares, or such other Securities, Spin-Off Securities options, warrants, or other rights or assets, as the case may be) on such dealing day, and (ii) may occur at any time after such dealing day, provided that where such Regular Closing Time occurs after 6 p.m. (Brussels time), such Bloomberg Screen Observation Time shall occur on the immediately following day (and no later than 1 p.m. (Brussels time) on such day) which is a Qualifying Business Day.

"**Bond Certificate**" has the meaning provided in the Bond Instrument.

"**Bond Conversion Right**" has the meaning provided in Condition 6.1 (Conversion Period and Conversion Price).

"**Bond Documents**" has the meaning provided in the Bond Instrument.

"**Bondholder**" and "**holder**" mean the person in whose name a Bond is registered in the Register (as defined in the Bond Instrument).

"**Bondholder Reserved Matter**" means an amendment or waiver of any term of the Bonds or the Bond Documents which has the effect of changing or which relates to:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) this definition of "Bondholder Reserved Matter" or the definition of "Majority Bondholders";

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) a modification of the date of payment (including any optional redemption pursuant to these Conditions) of any principal, interest, Cash Alternative Amount or other amount payable to a Bondholder under the Bonds or the Bond Documents;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) a variation in the amount or calculation of any payment of principal, interest, Cash Alternative Amount or other amount (including a number of Shares) payable or deliverable to a Bondholder under the Bonds or the Bond Documents;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) any modification or cancellation of the Conversion Rights or the rights of Bondholders to receive Shares and/or the Cash Alternative Amount on the exercise of Conversion Rights pursuant to these Conditions;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) any increase in the Conversion Price, other than in accordance with these Conditions;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) the right to receive Deliverable Shares following the exercise of a Share Settlement Option;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) any change in the governing law of the Bonds or the Bond Documents;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) a change in currency of payment of any amount under the Bonds or any Bond Document;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) a change to the Issuer as the issuing entity of the Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(j) a change to any provision which expressly requires the consent of Bondholders; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(k) any amendment to the rights of a Bondholder to assign or transfer its rights or obligations under the Bonds and/or the Bond Documents.

"**Bondholder Taxes**" has the meaning provided in Condition 6.9 (*Procedure for exercise of Conversion Rights*).

"**business day**" means, in relation to any place, a day (other than a Saturday or Sunday) on which commercial banks and foreign exchange markets are open for business in that place.

"**Cash Alternative Amount**" means, in respect of any exercise of Conversion Rights in respect of which the Issuer shall have made a Cash Alternative Election, an amount in EUR calculated by the Calculation Agent (and rounded to the nearest whole multiple of €0.01, with €0.005 rounded upwards) in accordance with the following formula and which shall be payable by the Issuer to a Bondholder in respect of the relevant Cash Settled Shares specified in the relevant Cash Alternative Election Notice:

CAA = S x P

where:

CAA=the Cash Alternative Amount

S=the Cash Settled Shares; and

P=the Volume Weighted Average Price of a Share (translated if necessary into EUR at the Prevailing Rate) on the relevant Conversion Date (or, if the Conversion Date is not a dealing day, the immediately preceding dealing day).

*Provided that*:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) if any Dividend or other entitlement in respect of the Shares is announced, (whether on or prior to or after the relevant Conversion Date) in circumstances where the record date or other due date for the establishment of entitlement in respect of such Dividend or other entitlement shall be on or after the relevant Registration Date (or, if there are no Physically Settled Shares in respect of such exercise of Conversion Rights, the relevant Conversion Date) and if the Volume Weighted Average Price on the Conversion Date (or, if the Conversion Date is not a dealing day, the immediately preceding dealing day) is based on a price ex- such Dividend or ex- such other entitlement, then such price shall be increased by an amount equal to the Fair Market Value of any such Dividend or other entitlement per Share as at the Ex-Date in respect of such Dividend or entitlement, determined by the Calculation Agent on a gross basis and disregarding any withholding or deduction required to be made for or on account of tax, and disregarding any associated tax credit, all as determined by the Calculation Agent;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) if any Retroactive Adjustment occurs in respect of the exercise of Conversion Rights in respect of which the Cash Alternative Amount is being determined, and if the Conversion Date (or, if the Conversion Date is not a dealing day, the immediately preceding dealing day) falls on or after the Applicable Adjustment Reference Date in respect of the event giving rise to such Retroactive Adjustment, the Volume Weighted Average Price on the Conversion Date (or, if the Conversion Date is not a dealing day, the immediately preceding dealing day) shall be multiplied by a fraction, (x) the numerator of which is the Conversion Price in effect immediately prior to the relevant adjustment to the Conversion Price becoming effective, and (y) the denominator of which is the Conversion Price so adjusted, all as determined by the Calculation Agent; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) if any doubt shall arise as to the calculation of the Cash Alternative Amount or if such amount cannot be determined as provided above, the Cash Alternative Amount shall be equal to such amount as is determined in such other manner as an Independent Adviser shall consider to be appropriate to give the intended result.

"**Cash Alternative Election**" has the meaning provided in Condition 6.10(a) (*Cash Alternative Election*).

"**Cash Alternative Election Date**" has the meaning provided in Condition 6.10(a) (*Cash Alternative Election*).

"**Cash Alternative Election Notice**" has the meaning provided in Condition 6.10(a) (*Cash Alternative Election*).

"**Cash Amortisation Price**" means:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) (in respect of any Amortised Payment Amount which is not an Advanced Amortised Payment Amount) 103 per cent. of the applicable Amortised Payment Amount; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) (in respect of any Advanced Amortised Payment Amount) the greater of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) 103 per cent. of such Advanced Amortised Payment Amount; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the product (rounded to the nearest whole multiple of €0.01, with €0.005 rounded upwards) of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) the quotient of (x) the Volume Weighted Average Price of the Shares (translated if necessary into EUR at the Prevailing Rate) on the dealing day immediately preceding the day on which the relevant Amortised Payment Advancement Notice is given (or deemed to be given pursuant to Condition 7.1(c)(ii)(B) (*Deferral and Advancement of Amortisation Payments*), and (y) the Relevant Share Settlement Price in respect of the relevant SSO Reference Date; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) such Advanced Amortised Payment Amount,

*provided that* if any doubt shall arise as to the calculation of the Cash Amortisation Price or if such amount cannot be determined as provided above, the Cash Amortisation Price shall be equal to such amount as is determined in such other manner as an Independent Adviser shall consider to be appropriate to give the intended result.

"**Cash Settled Shares**" means, in respect of the exercise of Conversion Rights by a Bondholder, such number of Shares (which shall be a whole number of Shares and shall not exceed the number

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of Reference Shares in respect of such exercise) as determined by the Issuer and notified to the relevant Bondholder in the relevant Cash Alternative Election Notice in accordance with Condition 6.10 (*Cash Alternative Election*).

"**Cash Settlement Ratio**" means, in respect of an exercise of Conversion Rights the subject of a Cash Alternative Election, such number as is equal to (a) the Cash Settled Shares in respect of such exercise of Conversion Rights divided by (b) the Reference Shares in respect of such exercise of Conversion Rights.

A "**Change of Control**" means the occurrence of an event or series of events whereby one or more persons, acting in concert, acquire Control over the Issuer.

"**Change of Control Conversion Right Amendment**" has the meaning provided in Condition 11(b)(vii) (*Undertakings*).

"**Change of Control Resolutions**" means, in the case of a Change of Control, one or more resolutions duly adopted at a general meeting of the Shareholders of the Issuer approving and confirming the provisions of Condition 6.2(j) and Condition 7.2 in accordance with Article 7:151 of the Belgian Companies and Associations Code.

"**Closing Price**" means, in respect of a Share or any other Security, Spin-Off Security, option, warrant or other right or asset, on any dealing day in respect thereof, the closing price on the Relevant Stock Exchange on such dealing day of a Share or, as the case may be, such other Security, Spin-Off Security, option, warrant or other right or asset, as published by or derived from Bloomberg page HP (or any successor page) (setting 'PR005 Last Price', or any other successor setting and using values not adjusted for any event occurring after such dealing day; and for the avoidance of doubt, all values will be determined with all adjustment settings on the DPDF Page, or any successor or similar setting, switched off) in respect of such Share, or, as the case may be, such other Security, Spin-Off Security, option, warrant or other right or asset (all as determined by the Calculation Agent as at the Bloomberg Screen Observation Time in respect of such dealing day) (and for the avoidance of doubt such Bloomberg page for the Shares as at the Issue Date is NYXH BB Equity HP), if available or, in any other case, such other source (if any) as shall be determined to be appropriate by an Independent Adviser on such dealing day, provided that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) if on any such dealing day (for the purpose of this definition, the "**Original Date**") such price is not available or cannot otherwise be determined as provided above, the Closing Price of a Share, such other Security, Spin-Off Security, option, warrant, or other right or asset, as the case may be, in respect of such dealing day shall be the Closing Price, determined by the Calculation Agent as provided above, on the immediately preceding dealing day in respect thereof on which the same can be so determined, provided however that if such immediately preceding dealing day falls prior to the fifth day before the Original Date, the Closing Price in respect of such dealing day shall be considered to be not capable of being determined pursuant to this proviso (a); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) if the Closing Price cannot be determined as aforesaid, the Closing Price of a Share, such other Security, Spin-Off Security, option, warrant, or other right or asset, as the case may be, shall be determined as at the Original Date by an Independent Adviser in such manner as it shall determine to be appropriate,

and the Closing Price determined as aforesaid on or as at any dealing day shall, if not in the Relevant Currency, be translated if necessary into the Relevant Currency at the Prevailing Rate on such dealing day.

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"**Concurrent Equity Raise**" means the primary placing of newly issued Shares pursuant to an equity private placement on the terms announced by the Issuer on 18 November 2025 (the "**Concurrent Equity Raise Pricing Date**").

"**Control**" means "control" within the meaning of Article 1:14 of the Belgian Companies and Associations Code and the terms "**Controlled**" and "**Controlling**" shall be construed accordingly.

"**Conversion Date**" has the meaning provided in Condition 6.9 (*Procedure for exercise of Conversion Rights*).

"**Conversion Notice**" means a notice (which shall be irrevocable) delivered by a Bondholder to the Issuer in or substantially in the form set out in Schedule 6 (*Form of Conversion Notice*) of the Bond Instrument.

"**Conversion Period**" has the meaning provided in Condition 6.1 (*Conversion Period and Conversion Price*).

"**Conversion Price**" has the meaning provided in Condition 6.1 (*Conversion Period and Conversion Price*).

"**Conversion Right**" has the meaning provided in Condition 6.1 (*Conversion Period and Conversion Price*).

"**Current Market Price**" means, in respect of a Share at a particular date, the arithmetic average of the daily Volume Weighted Average Price of a Share on each of the five consecutive dealing days ending on the dealing day immediately preceding such date, as determined by the Calculation Agent, *provided that*:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) for the purposes of determining the Current Market Price pursuant to Condition 6.2(d) (*Rights issues*) or 6.2(f) (*Issue of Shares at below Current Market Price*) in circumstances where the relevant event relates to an issue of Shares, if at any time during the said five dealing-day period (which may be on each of such five dealing days) the Volume Weighted Average Price shall have been based on a price ex-Dividend (or ex- any other entitlement) and/or during some other part of that period (which may be on each of such five dealing days) the Volume Weighted Average Price shall have been based on a price cum-Dividend (or cum- any other entitlement), in any such case which has been declared or announced, then:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) if the Shares to be so issued do not rank for the Dividend (or entitlement) in question, the Volume Weighted Average Price on the dates on which the Shares shall have been based on a price cum-Dividend (or cum- any other entitlement) shall for the purpose of this definition be deemed to be the amount thereof reduced by an amount equal to the Fair Market Value of any such Dividend or entitlement per Share as at the Ex-Date in respect of such Dividend or entitlement (or, where on each of the said five dealing days the Volume Weighted Average Price shall have been based on a price cum-Dividend (or cum-any other entitlement), as at the date of first public announcement of such Dividend or entitlement), in any such case, determined by the Calculation Agent on a gross basis and disregarding any withholding or deduction required to be made for or on account of tax, and disregarding any associated tax credit; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) if the Shares to be so issued do rank for the Dividend or entitlement in question, the Volume Weighted Average Price on the dates on which the Shares shall have been based on a price ex-Dividend (or ex- any other entitlement) shall for the

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purpose of this definition be deemed to be the amount thereof increased by an amount equal to the Fair Market Value of any such Dividend or entitlement per Share as at the Ex-Date in respect of such Dividend or entitlement, in any such case, determined by the Calculation Agent on a gross basis and disregarding any withholding or deduction required to be made for or on account of tax, and disregarding any associated tax credit;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) for the purpose of determining the Current Market Price of any Shares which may be comprised in a Scrip Dividend, if on any of the said five dealing days the Volume Weighted Average Price of the Shares shall have been based on a price cum all or part of such Scrip Dividend, the Volume Weighted Average Price of a Share on such dealing day or dealing days shall for the purposes of this definition be deemed to be the amount thereof reduced by an amount equal to the value (as determined in accordance with paragraph (a) of the definition of "**Dividend**") of such Scrip Dividend or part thereof; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) for any other purpose, if any day during the said five dealing-day period was the Ex-Date in relation to any Dividend (or any other entitlement) the Volume Weighted Average Prices that shall have been based on a price cum- such Dividend (or cum- such entitlement) shall for the purpose of this definition be deemed to be the amount thereof reduced by an amount equal to the Fair Market Value of any such Dividend or entitlement per Share as at the Ex-Date in respect of such Dividend or entitlement.

"**Daily Traded Value**" has the meaning provided in Condition 9.9(d) (*Annulment of Share Settlement Option*).

A "**De-Listing Event**" shall occur if:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the Shares at any time cease to be admitted to listing and trading on the Relevant Stock Exchange or the Relevant Stock Exchange announce that the Shares will cease to be admitted to listing and trading on such Relevant Stock Exchange, unless the Shares are already admitted to or are immediately (or substantially immediately) upon such cessation admitted to (or, in the case of such an announcement, are immediately (or substantially immediately) upon such announcement to be admitted to) listing and/or trading on another internationally recognised and regularly operating stock exchange; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) trading of the Shares on the Relevant Stock Exchange is suspended for a period of five consecutive Stock Exchange Dealing Days, provided that trading of the Shares shall not be considered to be suspended on any Stock Exchange Dealing Day on which a general suspension of trading on the Relevant Stock Exchange has occurred or where such suspension is in connection with a capital raise, merger, amalgamation or consolidation relating to the Issuer (and, in any such case, a De-Listing Event pursuant to this limb (b) shall be deemed to occur on the last day of such period of five consecutive Stock Exchange Dealing Days),

provided that following the occurrence of a De-Listing Event as provided above, no further De-Listing Event may occur unless, in the case of limb (a) above, the Shares shall subsequently have been listed and admitted to trading and listing on another internationally recognised and regularly operating stock exchange or, in the case of limb (b) above, such suspension shall have ceased.

"**Deferred Amortised Payment Amount**" has the meaning provided in Condition 7.1(c)(i) (*Deferral and Advancement of Amortisation Payments*).

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"**dealing day**" means, in respect of the Shares, other Securities, Spin-Off Securities options, warrants, or other rights or assets, a day (other than a Saturday or a Sunday) on which the Relevant Stock Exchange in respect thereof is open for business and on which such Shares, other Securities, Spin-Off Securities options, warrants or other rights or assets (as the case may be) may be dealt in (other than a day on which the Relevant Stock Exchange is scheduled to or does close prior to its regular weekday closing time), provided that, unless otherwise specified or the context otherwise requires, references to "dealing day" shall be a dealing day in respect of the Shares.

"**Deliverable Shares**" has the meaning provided in Condition 9.9(c) (*Certain Definitions*).

"**Disruption Event**" means either or both of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) a material disruption to those payment or share registration and/or delivery systems or to those markets which are, in each case, required to operate in order for payments and/or share registration and/or delivery obligations to be made in connection with these Conditions; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the occurrence of any other event which results in a disruption (of a technical or systems-related nature) to the treasury, share registration and/or delivery or payments operations of the Issuer preventing it from performing its Share delivery obligations under these Conditions,

and which (in either such case) is not caused by, and is beyond the control of, the Issuer.

"**Dividend**" means any dividend or distribution to Shareholders (including a Spin-Off) whether of cash, assets or other property, and however described and whether payable out of a share premium account, profits, retained earnings or any other capital or revenue reserve or account, and including a distribution or payment to Shareholders upon or in connection with a reduction of capital (and for these purposes a distribution of assets includes without limitation an issue of Shares or other Securities credited as fully or partly paid up by way of capitalisation of profits or reserves), provided that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) where a Scrip Dividend is announced, then the Scrip Dividend in question shall be treated as a cash Dividend of an amount equal to the sum of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) in respect of the portion (if any) of the Scrip Dividend (which may be the whole of the Scrip Dividend) for which a Shareholder or Shareholders may make an election, the value of the option with the highest value, with the value of each option being equal to the value of the relevant property comprising such option as at the Scrip Dividend Valuation Date provided that, in the case of an option comprising more than one type of property, the value of such option shall be equal to the sum of the values of each individual type of property comprising such option, determined as provided below; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) in respect of the portion (if any) of the Scrip Dividend (which may be the whole of the Scrip Dividend) which is not subject to such election, the value of such portion as determined as provided below,

and where the "**value**" of any property in or comprising of a Scrip Dividend shall be determined as follows:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(x) in the case of Shares comprised in such Scrip Dividend, the Current Market Price of such Shares as at the Scrip Dividend Valuation Date;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(y) in the case of cash comprising in such Scrip Dividend, the Fair Market Value of such cash as at the Scrip Dividend Valuation Date; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(z) in the case of any other property or assets comprised in such Scrip Dividend, the Fair Market Value of such other property or assets as at the Scrip Dividend Valuation Date;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) any issue of Shares falling within Condition 6.2(a) (*Consolidation, reclassification, redesignation or subdivision*) or Condition 6.2(b) (*Capitalisation of profits or reserves*) shall be disregarded;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) a purchase or redemption or buy back of any Shares of the Issuer by or on behalf of the Issuer or any of its Subsidiaries shall not constitute a Dividend unless, in the case of a purchase or redemption or buy back of Shares by or on behalf of the Issuer or any of its Subsidiaries, the weighted average price per Share (before expenses) on any day (a "**Specified Share Day**") in respect of such purchases or redemptions or buy backs (translated, if not in the Relevant Currency, into the Relevant Currency at the Prevailing Rate on such day) exceeds by more than 5 per cent. the Current Market Price of a Share:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) on the Specified Share Day; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) where an announcement (excluding, for the avoidance of doubt for these purposes, any general authority for such purchases, redemptions or buy backs approved by a general meeting of Shareholders or any notice convening such a meeting of Shareholders) has been made of the intention to purchase, redeem or buy back Shares at some future date at a specified price or where a tender offer is made, on the date of such announcement or, as the case may be, on the date of first public announcement of such tender offer (and regardless of whether or not a price per Share, a minimum price per Share or a price range or a formula for the determination thereof is or is not announced at such time),

in which case such purchase, redemption or buy back shall be deemed to constitute a Dividend in the Relevant Currency in an amount equal to the amount by which the aggregate price paid (before expenses) in respect of such Shares purchased, redeemed or bought back by or on behalf of the Issuer or, as the case may be, any of its Subsidiaries (translated where appropriate into the Relevant Currency as provided above) exceeds the product of (i) 105 per cent. of such Current Market Price and (ii) the number of Shares so purchased, redeemed or bought back;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) if the Issuer or any of its Subsidiaries (or any person on its or their behalf) shall purchase, redeem or buy back any depositary or other receipts or certificates representing Shares, the provisions of paragraph (c) above shall be applied in respect thereof in such manner and with such modifications (if any) as shall be determined by an Independent Adviser;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) where a dividend or distribution is paid or made to Shareholders pursuant to any plan or arrangement implemented by the Issuer for the purpose of enabling Shareholders to elect, or which may require Shareholders, to receive dividends or distributions in respect of the Shares held by them from a person other than (or in addition to) the Issuer, such dividend or distribution shall for the purposes of these Conditions be treated as a dividend or distribution made or paid to Shareholders by the Issuer, and the foregoing provisions of this definition and the provisions of these Conditions shall be construed accordingly;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) where a Dividend in cash is declared which provides for payment by the Issuer in the Relevant Currency (or, in the case of a Scrip Dividend, an amount in cash is or may be paid in the Relevant Currency, whether at the option of Shareholders or otherwise), it shall be treated as a Dividend in cash (or, in the case of a Scrip Dividend, an amount in cash) in such Relevant Currency, and in any other case it shall be treated as a Dividend in cash (or, in the case of a Scrip Dividend an amount in cash) in the currency in which it is payable by the Issuer; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) a dividend or distribution that is a Spin-Off shall be deemed to be a Dividend paid or made by the Issuer,

and any such determination shall be made by the Calculation Agent or, where specifically provided, an Independent Adviser and, in either such case, on a gross basis and disregarding any withholding or deduction required to be made for or on account of tax, and disregarding any associated tax credit.

"**DTC**" means The Depository Trust Company, a limited purpose trust company organised under the laws of the State of New York, and its successors and assigns.

"**Early Redemption Amount**" means in respect of any Bond, the sum of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the Make-Whole Premium; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) an amount equal to the greater of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) 120 per cent. of the principal amount of such Bond outstanding on the relevant Early Redemption Amount Date; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the relevant Parity Value of a Bond,

where for the purposes of this definition, "**Early Redemption Amount Date**" means (1) in the case of a redemption pursuant to Condition 7.2 (*Redemption at the Option of Bondholders (Relevant Event*)), the Relevant Event Put Date, or (2) in the case of an amount becoming due pursuant to Condition 10 (*Events of Default*), the date of the giving of notice by the holders of at least one-quarter in principal amount of the Bonds then outstanding in accordance with the first paragraph of Condition 10 (*Events of Default*);

"**EIB Facility**" means the €37,500,000 facility agreement dated 3 July 2024 entered into between the European Investment Bank and the Issuer, as amended from time to time.

"**Enterprise Court**" means the Belgian court (Ondernemingsrechtbank/Tribunal de l'entreprise) established under Belgian law, which has jurisdiction over disputes relating to enterprises, commercial matters, and insolvency proceedings in Belgium.

"**Equity-Linked Rights**" has the meaning provided in Condition 6.4 (*Conversion Price Reset*).

"**Equity Raise**" has the meaning provided in Condition 6.4 (*Conversion Price Reset*).

"**equity shares**" means (other than for the purposes of Condition 6.2(c)) (*Dividends*), in relation to any entity, its total issued shares excluding any shares which, neither as respects dividends nor as respects capital, carries any right to participate beyond a specific amount in a distribution.

"**Euroclear Belgium**" means Caisse Interprofessionnelle de Dépôts et de Virements de Titres SA/Interprofessionnele Effectendepositen Girokas NV (C.I.K.) (commercial name Euroclear

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Belgium), enterprise number 0403 206 432 (Register of Legal Entities for Brussels), or any entity replacing the same as a central securities depository.

"**Euronext Brussels**" means the EEA Regulated Market of Euronext Brussels.

"**Event of Default**" has the meaning provided in Condition 10 (*Events of Default*).

"**Ex-Date**" means, in relation to any Dividend (including without limitation any Spin-Off), capitalisation, redesignation, reclassification, sub-division, consolidation, issue, grant, offer or other entitlement, unless otherwise defined herein, the first dealing day for the Shares on which the Shares are traded ex- the relevant Dividend, capitalisation, redesignation, reclassification, sub-division, consolidation, issue, grant, offer or other entitlement on the Relevant Stock Exchange (or, in the case of a Dividend which is a purchase, redemption or buy back of Shares (or, as the case may be, any depositary or other receipts or certificates representing Shares) pursuant to paragraph (c) (or, as the case may be, paragraph (d)) of the definition of "Dividend", the date on which such purchase, redemption or buy back is made), and provided that, for the avoidance of doubt, the Ex-Date in respect of a Scrip Dividend shall be deemed to be the Ex-Date in respect of the relevant Dividend or capitalisation as referred to in the definition of "Scrip Dividend".

"**Excess Shares**" has the meaning provided in Condition 17(e) (*Beneficial Ownership of Shares*).

"**Exchange Act**" means the U.S. Securities Exchange Act of 1934, as amended.

"**Excluded Instrument**" means any of the following:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the 1,400,000 subscription rights (*inschrijvingsrechten / droits de souscription*) issued by the Issuer on 8 September 2021 pursuant to the 2021 warrants plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the 700,000 subscription rights (*inschrijvingsrechten / droits de souscription*) issued by the Issuer on 28 December 2022 pursuant to the 2022 warrants plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) the 1,000,000 subscription rights (*inschrijvingsrechten / droits de souscription*) issued by the Issuer on 31 July 2024 pursuant to the 2024 warrants plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) the 805,000 subscription rights (*inschrijvingsrechten / droits de souscription*) issued by the Issuer on 30 January 2025 pursuant to the 2025 warrants plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) the 760,000 subscription rights (*inschrijvingsrechten / droits de souscription*) issued by the Issuer on 13 October 2025 pursuant to the 2025-2 warrants plan; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) the subscription rights (*inschrijvingsrechten / droits de souscription*), Shares, or restricted stock units to be issued or granted to directors of personnel of the Issuer (or its affiliates) from time to time in accordance with the remuneration policy of the Issuer, as amended; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) any subscription rights (*inschrijvingsrechten / droits de souscription*) that may be issued from time to time under any other personnel incentive plan,

*provided that,* on any date, (x) the Excluded Instruments, taken together, shall not entitle the beneficiaries thereof the right to subscribe for, acquire, or otherwise receive Shares in an aggregate number exceeding 10.0 per cent. of the Issuer's issued share capital (it being understood that any such subscription rights (*inschrijvingsrechten / droits de souscription*), Shares or restricted stock units issued in excess of the foregoing limitation shall not constitute an Excluded Instrument), and (y) in the case of paragraphs (g) and (h), the issuance of such subscription rights (*inschrijvingsrechten / droits de souscription*), Shares or restricted stock units are issued pursuant

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to any remuneration policy or other personnel incentive plan that is duly approved by the Issuer's board of directors and (if applicable) its shareholders. Any reference in these Conditions to "**Excluded Instruments**" means all of them.

"**Fair Market Value**" means, on any date (the "**FMV Date**"):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) in the case of a cash Dividend, the amount of such cash Dividend, as determined by the Calculation Agent;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) in the case of any other cash amount, the amount of such cash, as determined by the Calculation Agent;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) in the case of Securities (including Shares), Spin-Off Securities, options, warrants or other rights or assets that are publicly traded on a Relevant Stock Exchange of adequate liquidity (as determined by the Calculation Agent or an Independent Adviser), the arithmetic mean of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) in the case of Shares or (to the extent constituting equity shares) other Securities or Spin-Off Securities, for which a daily Volume Weighted Average Price (disregarding for this purpose proviso (ii) to the definition thereof) can be determined, such daily Volume Weighted Average Price of the Shares or such other Securities or Spin-Off Securities; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) in any other case, the Closing Price of such Securities, Spin-Off Securities, options, warrants or other rights or assets,

in the case of both (a) and (b) during the period of five dealing days on the Relevant Stock Exchange for such Securities, Spin-Off Securities, options, warrants or other rights or assets commencing on such FMV Date (or, if later, the date (the "**Adjusted FMV Date**") which falls on the first such dealing day on which such Securities, Spin-Off Securities, options, warrants or other rights or assets are publicly traded, provided that where such Adjusted FMV Date falls after the fifth day following the FMV Date, the Fair Market Value of such Securities, Spin-Off Securities, options, warrants or other rights or assets shall instead be determined pursuant to paragraph (d) below, and no such Adjusted FMV Date shall be deemed to apply) or such shorter period as such Securities, Spin-Off Securities, options, warrants or other rights or assets are publicly traded, all as determined by the Calculation Agent;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) in the case of Securities, Spin-Off Securities, options, warrants or other rights or assets that are not publicly traded on a Relevant Stock Exchange of adequate liquidity (as aforesaid) or where otherwise provided in paragraph (c) above to be determined pursuant to this paragraph (d), an amount equal to the fair market value of such Securities, Spin-Off Securities, options, warrants or other rights or assets as determined by an Independent Adviser, on the basis of a commonly accepted market valuation method and taking account of such factors as it considers appropriate, including the market price per Share, the dividend yield of a Share, the volatility of such market price, prevailing interest rates and the terms of such Securities, Spin-Off Securities, options, warrants or other rights or assets, and including as to the expiry date and exercise price or the like (if any) thereof.

Such amounts shall (if not expressed in the Relevant Currency on the FMV Date (or, as the case may be, the Adjusted FMV Date)) be translated if necessary into the Relevant Currency at the Prevailing Rate on the FMV Date (or, as the case may be, the Adjusted FMV Date), all as determined by the Calculation Agent.

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In addition, in the case of (a) and (b) above, the Fair Market Value shall be determined on a gross basis and disregarding any withholding or deduction required to be made for or on account of tax, and disregarding any associated tax credit.

"**Final Maturity Date**" means, at any time, the Original Final Maturity Date, and/or, following any Amortised Payment Advancement in accordance with Condition 7.1(c)(ii) (*Deferral and Advancement of Amortisation Payments*)), such earlier date on which, as at such time, the Bonds are scheduled to be redeemed in full in accordance with Condition 7.1(c)(ii) (*Deferral and Advancement of Amortisation Payments*).

"**Financial Indebtedness**" means any indebtedness of any person for or in respect of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) moneys borrowed;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) amounts raised by acceptance under any acceptance credit facility;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) amounts raised pursuant to any note purchase facility or the issue of bonds, notes, debentures, loan stock or similar instruments (including any such instruments which by their terms carry (directly or indirectly) rights of conversion into, or exchange or subscription for, or the right to otherwise acquire, any shares in the capital of the Issuer or any of its Subsidiaries);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) the amount of any liability in respect of any finance leases that is incurred in the ordinary course of the Issuer or a Subsidiary's business (as the case may be);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) the amount of any liability in respect of any purchase price for assets or services the payment of which is deferred primarily as a means of raising finance or financing the acquisition of the relevant asset or service;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) amounts raised under any other transaction (including any forward sale or purchase agreement and the sale of receivables or other assets on a "with recourse" basis) having the commercial effect of a borrowing;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) any derivative transaction entered into in connection with protection against or benefit from fluctuation in any rate or price (and, when calculating the value of any derivative transaction, only the mark-to-market value shall be taken into account);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) any counter-indemnity obligation in respect of any guarantee, indemnity, bond, standby or documentary letter of credit or any other instrument issued by a bank or financial institution; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) (without double counting) the amount of any liability in respect of any guarantee or indemnity for any of the items referred to in paragraphs (a) to (h) above.

"**Financial Indebtedness Guarantee**" means in relation to any Financial Indebtedness of any person, any obligation of another person to pay such indebtedness including (without limitation):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) any obligation to purchase such indebtedness;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) any obligation to lend money, to purchase or subscribe shares or other securities or to purchase assets or services in order to provide funds for the payment of such indebtedness;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) any indemnity against the consequences of a default in the payment of such indebtedness; and

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) any other agreement to be responsible for repayment of such indebtedness.

"**Free Float**" means all issued and outstanding Shares less (i) the aggregate of those Shares held by any person (other than a collective investment scheme, mutual fund, pension fund or other investment trust, in each case which is traded on a regulated market) holding five per cent. or more of the issued and outstanding Shares; (ii) the aggregate of those Shares held by any person or persons who have entered into shareholders' agreements or lock-up agreements concerning the Shares with a duration of more than six months; and (iii) any Shares held by or on behalf of the Issuer or any related party or affiliate.

A "**Free Float Event**" shall be deemed to have occurred if the Free Float of the Issuer is less than 10 per cent. of the issued and outstanding Shares on each Qualifying Business Day comprised in any period of 10 consecutive Qualifying Business Days (and in any such case the Free Float Event shall be deemed to occur on the last Qualifying Business Day of such period), *provided that* following the occurrence of any Free Float Event as provided above, no further Free Float Event may occur unless the Free Float of the Issuer shall subsequently have been at least 10 per cent. of the issued and outstanding Shares for a period of 10 consecutive Qualifying Business Days commencing at any time after the Relevant Event Put Date in respect of the immediately preceding Free Float Event.

"**Further Bonds**" means further bonds either having the same terms and conditions in all respects as the outstanding Bonds or having the same terms and conditions in all respects as the outstanding Bonds in all respects except for the first payment of interest on them and the first date on which Conversion Rights may be exercised and so that such further issue shall be consolidated and form a single series with the outstanding Bonds, and in each case which shall be issued only in accordance with Condition 17 (*Beneficial Ownership of Shares*).

"**IFRS**" means International Financial Reporting Standards issued by the International Accounting Standards Board (IASB) and interpretations issued by the International Reporting Interpretations Committee of the IASB (as amended, supplemented or re-issued from time to time).

"**Independent Adviser**" means an independent adviser with appropriate expertise, which may be the Calculation Agent appointed by the Issuer at its own expense and (other than where the initial Calculation Agent is appointed) approved in writing by the Majority Bondholders (acting reasonably) or, if the Issuer fails to make such appointment and such failure continues for a period of 14 days, as may be appointed by the Majority Bondholders (at the expense of the Issuer, and without liability for so doing) following notification to the Issuer, which appointment shall be deemed to be made by the Issuer.

"**Initial Conversion Price**" has the meaning provided in Condition 6.1 (*Conversion Period and Conversion Price*).

"**Interest Payment Date**" has the meaning provided in Condition 5.1(a) (*Interest Rate*).

"**Interest Period**" has the meaning provided in Condition 5.1(a) (*Interest Rate*).

"**Issue Date**" means 18 December 2025.

"**Longstop Date**" means the date of the annual shareholders' meeting of the Issuer resolving on the Issuer's financial statements as of and for the year ending 31 December 2025.

"**Majority Bondholders**" means, at any time, holders of more than 50 per cent. of the principal amount of the Bonds outstanding.

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"**Make-Whole Premium**" means the (undiscounted) sum of all remaining scheduled interest payments due on the Bonds falling on or after the Early Redemption Amount Date, as calculated by the Calculation Agent.

"**Maximum Percentage**" has the meaning provided in Condition 17(a) (*Beneficial Ownership of Shares*).

"**Minimum PMP**" has the meaning provided in Condition 9.9(d) (*Annulment of Share Settlement Option*).

"**Offer Period**" has the meaning provided in Condition 9.9(c) (*Certain Definitions*).

"**Original Final Maturity Date**" means 18 November 2028, being the date falling on the three-year anniversary of the Concurrent Equity Raise Pricing Date.

"**outstanding**" means, in relation to the Bonds, all Bonds issued except (a) those which have been redeemed in accordance with these Conditions, (b) those in respect of which Conversion Rights have been exercised and the Issuer's obligations to issue and/or deliver Shares (and/or, in the case of a Cash Alternative Election, the Issuer's obligation to pay the Cash Alternative Amount) have been duly performed, (c) those in respect of which the date for redemption has occurred and the redemption moneys (including all interest accrued on such Bonds to the date for such redemption and any interest payable under Condition 5 (*Interest*) after such date) have been duly paid to the relevant Bondholder and for any obligations to issue or deliver Shares have been performed, and (d) those which have been redeemed and cancelled as provided in Condition 7 (*Redemption of Bonds*); *provided that* for the purposes of (1) ascertaining the right to vote on any voting matters pursuant to Condition 15 (*Amendment and Waiver*), (2) the determination of how many and which Bonds are outstanding for the purposes of Conditions 10 (*Events of Default*) and 15 (*Amendment and Waiver*), and (3) the exercise of any discretion, power or authority which each Bondholder is required, expressly or impliedly, to exercise, those Bonds which are beneficially held by or on behalf of the Issuer or any of its Subsidiaries or any of their respective affiliates and not cancelled shall (unless no longer so held) be deemed not to remain outstanding.

"**Parity Value**" of a Bond means the product (rounded to the nearest whole multiple of €0.01 (with €0.005 being rounded upwards)) of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) such number of Shares per Bond as would have been required to be issued or transferred and delivered in respect of such Bond had Conversion Rights been exercised in respect thereof, assuming for this purpose that the Conversion Date relating to such exercise of Conversion Rights is the Early Redemption Amount Date; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the arithmetic mean of the Volume Weighted Average Price of a Share (translated if necessary into EUR at the Prevailing Rate) on each dealing day comprised in the period of five consecutive dealing days ending on (and including) the second dealing day preceding the Early Redemption Amount Date,

in each case, all as determined by the Calculation Agent, *provided that* if (A) such period of five consecutive dealing days as aforesaid is not comprised in the period of 10 consecutive Brussels business days ending on (and including) the second Brussels business day immediately preceding the Early Redemption Amount Date, as the case may be, or (B**)** any doubt shall arise as to the calculation of the Parity Value or if such amount cannot be determined as provided above, in each case the Parity Value shall be equal to such amount as is determined in such other manner as an Independent Adviser shall consider to be appropriate to give the intended result.

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

"**Payment Details**" means, with respect to each Bondholder, the instructions provided by it to the Issuer (with a copy to the Calculation Agent) for the payment to the Bondholder of EUR cash payments and issue or transfer and delivery to the Bondholder of Shares (and which shall, for so long as the Shares are held through Euroclear Belgium or DTC, include Euroclear Belgium or DTC (as the case may be) account details), and which may be updated by a Bondholder at any time by giving notice to the Issuer in accordance with Condition 16 (*Notices*).

a "**person**" includes any individual, firm, company, corporation, government, state or agency of a state or any association, trust, joint venture, consortium, partnership or other entity (whether or not having separate legal personality).

"**Physically Settled Shares**" means, in respect of any exercise of Conversion Rights, (i) the Reference Shares or (ii) where such exercise is the subject of a Cash Alternative Election, such number of Shares (which may be equal to zero) as is equal to the Reference Shares minus the Cash Settled Shares.

"**Placing Price**" has the meaning provided in Condition 6.4 (*Conversion Price Reset*).

"**Placing Proceeds**" has the meaning provided in Condition 6.4 (*Conversion Price Reset*).

"**Potential Event of Default**" means an event or circumstance which would, with the giving of notice, lapse of time, issue of a certificate and/or fulfilment of any other requirement provided for in Condition 10 (*Events of Default*), become an Event of Default.

"**Prevailing Market Price**" has the meaning provided in Condition 9.9(d) (*Annulment of Share Settlement Option*).

"**Prevailing Rate**" means, in respect of any pair of currencies on any day, the spot mid-rate of exchange between the relevant currencies prevailing as at 4.00 p.m. (London time) on that date (for the purpose of this definition, the "**Original Date**") as appearing on or derived from Bloomberg page BFIX (or any successor page) in respect of such pair of currencies, or, if such a rate cannot be so determined, the rate prevailing as at 4.00 p.m. (London time) on the immediately preceding day on which such rate can be so determined, provided that if such immediately preceding day falls earlier than the fifth day prior to the Original Date or if such rate cannot be so determined (all as determined by the Calculation Agent), the Prevailing Rate in respect of the Original Date shall be the rate determined in such other manner as an Independent Adviser shall consider appropriate.

"**Put SSO Reference Date**" means, for the purpose of Condition 7.2 (*Redemption at the Option of Bondholders (Relevant Event)*), Condition 7.3 (Redemption if the Change of Control Resolutions are not passed) or Condition 10 (*Events of Default*), the dealing day immediately preceding the first date on which the relevant Early Redemption Amount is capable of being determined in accordance with these Conditions.

"**Qualifying Business Day**" means each of (a) a Brussels business day, and (b) a New York business day.

"**Qualifying Equity Raise**" has the meaning provided in Condition 6.4 (*Conversion Price Reset*).

"**Qualifying Stock Exchange Day**" means any day which appears as a trading day (other than a day on which such trading is scheduled to close prior to its regular weekday closing time) on each of:

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Bloomberg page CDR using the calendar setting for the Relevant Stock Exchange in respect of the Shares (such calendar setting being as at the Issue Date, for the avoidance of doubt, "BU" ("Euronext Brussels") (or any successor page or setting)); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) (if the Shares are listed and admitted to trading on any of the US Markets) Bloomberg page CDR using the calendar "EX" ("US exchanges") (or any successor page or setting).

"**Rate of Interest**" has the meaning provided in Condition 5.1(a) (*Interest Rate*).

"**Record Date**" has the meaning provided in Condition 9.3 (*Record Date*).

"**Reference Date**" means, in relation to a Retroactive Adjustment, the date as of which the relevant Retroactive Adjustment takes effect or, in any such case, if that is not a dealing day, the next following dealing day.

"**Reference Lowest Daily Market Price**" has the meaning provided in Condition 9.9(c) (*Certain Definitions*).

"**Reference Shares**" means, in respect of the exercise of Conversion Rights by a Bondholder, the number of Shares (rounded down, if necessary, to the nearest whole number) determined by the Calculation Agent by dividing the principal amount of the Bonds (or, as the case may be, the aggregate principal amount of the Upcoming Amortised Payment Amount(s)) which are the subject of the relevant exercise of Conversion Rights by the Conversion Price in effect on the relevant Conversion Date.

"**Registration Date**" has the meaning provided in Condition 6.11 (*Ranking and entitlement*).

"**Regular Amortisation Period**" means each period beginning on (and including) a Scheduled Amortisation Payment Date and ending on (but excluding) the next succeeding Scheduled Amortisation Payment Date.

"**Regular Closing Time**" means, in respect of the Shares, or other Securities, Spin-Off Securities, options, warrants, or other rights or assets, the regular weekday time at which the main trading session is scheduled to end (or, if later, such regular weekday time at which the closing price or final fixing price in respect of such main trading session is scheduled to be published) for the Shares, or such other Securities, Spin-Off Securities options, warrants, or other rights or assets on the Relevant Stock Exchange in respect thereof (whether or not on any dealing day such main trading session is scheduled to end or ends (or, as the case may be, such closing price or final fixing price as aforesaid is scheduled to be published or is published) prior to such regular weekday time as aforesaid. For the avoidance of doubt, as at the Issue Date, the Regular Closing Time in respect of the Shares and the Relevant Stock Exchange in respect thereof is 5:35 p.m. (Brussels time).

"**Relevant Currency**" means, at any time, the currency in which the Shares are quoted or dealt in at such time on the Relevant Stock Exchange in respect thereof.

"**Relevant Date**" means, in respect of any Bond, whichever is the later of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the date on which payment in respect of it first becomes due; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) if any amount payable is improperly withheld or refused, the date on which payment in full of the amount outstanding is made to Bondholders.

A "**Relevant Event**" shall occur if a Change of Control, a De-Listing Event or a Free Float Event occurs.

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

"**Relevant Event Conversion Price**" has the meaning provided in Condition 6.2(j) (*Relevant Event*).

"**Relevant Event Notice**" has the meaning provided in Condition 6.8 (*Relevant Event*).

"**Relevant Event Period**" means the period commencing on the date on which a Relevant Event occurs and ending five Brussels business days following such date or, if later, (unless such extension is waived by the Majority Bondholders) five Brussels business days following the date on which the Relevant Event Notice is given to Bondholders as required by Condition 7.2 (*Redemption at the Option of Bondholders (Relevant Event*)).

"**Relevant Event Put Date**" has the meaning provided in Condition 7.2 (*Redemption at the Option of Bondholders (Relevant Event*)).

"**Relevant Stock Exchange**" means:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) in respect of the Shares, Euronext Brussels or, if the Shares cease to be listed and admitted on Euronext Brussels (or any other stock exchange or securities market which is, as a result of the operation of this limb (a), the then prevailing Relevant Stock Exchange in respect of the Shares), such other principal stock exchange or securities market on which such Shares are (at the time of such cessation) listed and admitted to trading, if applicable; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) in respect of any Securities (other than Shares), Spin-Off Securities, options, warrants or other rights or assets, the principal stock exchange or securities market on which such Securities, Spin-Off Securities, options, warrants or other rights or assets are then listed and admitted to trading,

where "**principal stock exchange or securities market**" shall mean the stock exchange or securities market on which such Shares, such other Securities, Spin-Off Securities, options, warrants or other rights or assets are listed and admitted to trading, provided that if such Shares, such other Securities, Spin-Off Securities, options, warrants or other rights or assets are listed and admitted to trading on more than one stock exchange or securities market at the relevant time, then "**principal stock exchange or securities market**" shall mean that stock exchange or securities market on which such Shares, such other Securities, Spin-Off Securities, options, warrants or other rights or assets are then listed and admitted to trading as determined by the Calculation Agent (if the Calculation Agent determines that it is able to make such determination in its capacity as Calculation Agent) or (in any other case) by an Independent Adviser by reference to the stock exchange or securities market with the then prevailing highest 2-month average daily trading volume (as determined by reference to the Daily Traded Value) in respect of such Shares, such other Securities, Spin-Off Securities, options, warrants or other rights or assets.

"**Reported Outstanding Share Number**" has the meaning provided in Condition 17(c) (*Beneficial Ownership of Shares*).

"**Reporting Company**" means a company that is required to file reports periodically with the U.S. Securities and Exchange Commission under section 12, 13 or 15(d) of the Exchange Act.

"**Restricted Information**" means any information that is or may be material non-public and price-sensitive or is insider information within the meaning of applicable insider dealing or market abuse law (including Regulation 596/2014/EU).

A "**Retroactive Adjustment**" shall occur in respect of any exercise of Conversion Rights if (i) the Registration Date (or, if there are no Physically Settled Shares in respect of such exercise of Conversion Rights, the Conversion Date) in respect of such exercise shall be after the Applicable

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

Adjustment Record Date in respect of any event giving rise to an adjustment to the Conversion Price pursuant to Condition 6.2 (*Adjustment of Conversion Price*) and (ii) the Conversion Date in respect of such exercise shall be before such adjustment becomes effective under Condition 6.2 (*Adjustment of Conversion Price*).

"**Second Tranche Bonds**" means the amortising senior convertible bonds which may be issued by the Issuer in an aggregate principal amount not exceeding €22,500,000 between 18 July 2026 and 18 August 2026, subject to and in accordance with the terms of the Subscription Agreement.

"**Securities Act**" means the U.S. Securities Act of 1933, as amended.

"**Security Interest**" means a mortgage, charge, pledge, lien or other security interest securing any obligation of any person or any other agreement or arrangement having a similar effect.

"**Scheduled Amortisation Payment Date**" has the meaning provided in Condition 7.1(a) (*Scheduled Amortisation Payments*).

"**Scheduled Delivery Date**" has the meaning provided in Condition 6.9 (*Procedure for exercise of Conversion Rights*).

"**Scheduled SSO Delivery Date**" has the meaning provided in Condition 9.9(b) (*Share Settlement*).

"**Scrip Dividend**" means:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) a Dividend in cash which is to be satisfied, or a Dividend in cash which may at the election of a Shareholder or Shareholders be satisfied, in whole or in part, by the issue or delivery of Shares and/or other property or assets; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) an issue of Shares or other property or assets by way of a capitalisation of profits or reserves (including any share premium account or capital redemption reserve, and whether described as a scrip or share dividend or distribution or otherwise) which is to be satisfied, or which may at the election of a Shareholder or Shareholders be satisfied, in whole or in part, by the payment of cash.

"**Scrip Dividend Valuation Date**" means:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) in respect of any portion of a Scrip Dividend for which a Shareholder or Shareholders may make an election, the later of (i) the Ex-Date in relation to the relevant dividend or capitalisation, (ii) the last day on which the relevant election can be made by such Shareholder or Shareholders, and (iii) the date on which the number of Shares, amount of cash, or amount of other property or assets, as the case may be, which may be issued or delivered is publicly announced; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) in respect of any portion of a Scrip Dividend which is not subject to such election, the later of (i) the Ex-Date in relation to the relevant dividend or capitalisation and (ii) the date on which the number of Shares, amount of cash or amount of such other property or assets, as the case may be, to be issued and delivered is publicly announced.

"**Securities**" means any securities including, without limitation, Shares and any other shares of the Issuer, and options, warrants or other rights to subscribe for or purchase or acquire Shares or any other shares of the Issuer.

"**Share Average DTV**" has the meaning provided in Condition 9.9(a) (*Exercise of Share Settlement Option*).

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

"**Share Settlement**" has the meaning provided in Condition 9.9(b) (*Share Settlement*).

A "**Share Settlement Free Float Event**" shall be deemed to have occurred on any Qualifying Business Day in the Share Settlement Liquidity Period (the "**Relevant Qualifying Business Day**") if the Free Float of the Issuer is less than 10 per cent. of the issued and outstanding Shares on each Qualifying Business Day comprised in the period of 10 consecutive Qualifying Business Days ending on (and including) such Relevant Qualifying Business Day.

"**Share Settlement Liquidity Event**" has the meaning provided in Condition 9.9(a) (*Exercise of Share Settlement Option*).

"**Share Settlement Liquidity Period**" has the meaning provided in Condition 9.9(a) (*Exercise of Share Settlement Option*).

"**Shareholders**" means the holders of Shares.

"**Shares**" means fully paid ordinary shares in the capital of the Issuer, with (as at the Issue Date) no nominal value and ISIN BE0974358906 (and each, a "**Share**").

"**Specified Date**" has the meaning provided in Conditions 6.2(f) (*Issue of Shares at below Current Market Price*), 6.2(g) (*Other issues*) and 6.2(h) (*Modification of rights*).

"**Specified Taxes**" has the meaning provided in Condition 6.9 (*Procedure for exercise of Conversion Rights*).

"**Spin-Off**" means:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) a distribution of Spin-Off Securities by the Issuer to Shareholders as a class; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) any issue, transfer or delivery of any property or assets (including cash or shares or other securities of or in or issued or allotted) by any entity (other than the Issuer) to Shareholders as a class pursuant to any arrangements with the Issuer or any of its Subsidiaries.

"**Spin-Off Securities**" means equity shares of an entity other than the Issuer or options, warrants or other rights to subscribe for or purchase equity shares of an entity other than the Issuer.

"**SSO Reference Date**" has the meaning provided in Condition 9.9(c) (*Certain Definitions*).

"**SSO Registration Date**" has the meaning provided in Condition 9.9(e) (*Provisions relating to any Share Settlement Option*).

"**Stock Exchange Dealing Day**" means a day (other than a Saturday or a Sunday) on which the Relevant Stock Exchange in respect of the Shares is open for business (whether or not such day is a dealing day) (other than a day on which such Relevant Stock Exchange is scheduled to close prior to its regular weekday closing time).

"**Subscription Agreement**" means the subscription agreement originally dated 13 November 2025 (as amended and restated on 16 December 2025) between the Issuer and the initial subscriber named therein in connection with the subscription and issuance of the Bonds and the Second Tranche Bonds.

"**Subsidiary**" means, in relation to any person (the "**first Person**") at any particular time, any other person (the "**second Person**") (i) whose affairs and policies the first Person controls or has the power to control, whether by ownership of shares, contract, the power to appoint or remove members of the governing body of the second Person or otherwise or (ii) whose assets, liabilities,

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

equity, income, expenses and cash flows are, in accordance with applicable law and the International Standards on Auditing issued by the International Federation of Accountants (as amended, supplemented or re-issued from time to time), consolidated with those of the first Person in the consolidated financial statements of such person.

"**Tax Jurisdiction**" has the meaning provided in Condition 8 (*Taxation*).

"**Tax Withholding**" has the meaning provided in Condition 8 (*Taxation*).

"**Upcoming Amortised Payment Amount**" has the meaning provided in Condition 6.1 (*Conversion Period and Conversion Price*).

"**US Market**" means each of The Nasdaq Global Market, The Nasdaq Global Select Market and The New York Stock Exchange (or any of their respective successors).

"**US Share**" means any Share that is required pursuant to these Conditions to be issued or transferred and delivered in uncertificated form through the dematerialised securities trading system operated by DTC on exercise of Conversion Rights or the Share Settlement Option.

"**Volume Weighted Average Price**" means, in respect of a Share, such other Security or, as the case may be, a Spin-Off Security, on any dealing day in respect thereof, the volume weighted average price on such dealing day on the Relevant Stock Exchange of a Share or, as the case may be, such other Security or Spin-Off Security, as published by or derived from Bloomberg page HP (or any successor page) (setting 'PR094 VWAP (Vol Weighted Average Price)' or any other successor setting and using values not adjusted for any event occurring after such dealing day; and for the avoidance of doubt, all values will be determined with all adjustment settings on the DPDF Page, or any successor or similar setting, switched off) in respect of such Share or, as the case may be, such other Security or Spin-Off Security (all as determined by the Calculation Agent as at the Bloomberg Screen Observation Time in respect of such dealing day) (and for the avoidance of doubt such Bloomberg page for the Shares as at the Issue Date is NYXH BB Equity HP) if available or, in any other case, such other source (if any) as shall be determined to be appropriate by an Independent Adviser on such dealing day provided that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) if on any such dealing day (for the purposes of this definition, the "**Original Date**") such price is not available or cannot otherwise be determined as provided above, the Volume Weighted Average Price of a Share, such other Security or Spin-Off Security, as the case may be, in respect of such dealing day shall be the Volume Weighted Average Price, determined as provided above, on the immediately preceding dealing day in respect thereof on which the same can be so determined, provided however that if such immediately preceding dealing day falls prior to the fifth day before the Original Date, the Volume Weighted Average Price in respect of such dealing day shall be considered to be not capable of being determined pursuant to this proviso (a); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) if the Volume Weighted Average Price cannot be determined as aforesaid, the Volume Weighted Average Price of a Share, such other Security or Spin-Off Security, as the case may be, shall be determined as at the Original Date by an Independent Adviser in such manner as it shall determine to be appropriate,

and the Volume Weighted Average Price determined as aforesaid on or as at any dealing day shall, if not in the Relevant Currency, be translated if necessary into the Relevant Currency at the Prevailing Rate on such dealing day.

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

References to any act or statute or any provision of any act or statute shall be deemed also to refer to any statutory modification or re-enactment thereof or any statutory instrument, order or regulation made thereunder or under such modification or re-enactment.

References to any issue or offer or grant to Shareholders or Existing Shareholders "**as a class**" or "**by way of rights**" shall be taken to be references to an issue or offer or grant to all or substantially all Shareholders or Existing Shareholders, as the case may be, other than Shareholders or Existing Shareholders, as the case may be, to whom, by reason of the laws of any territory or requirements of any recognised regulatory body or any other stock exchange or securities market in any territory or in connection with fractional entitlements, it is determined not to make such issue or offer or grant.

In making any calculation or determination of Reference Lowest Daily Market Price, Current Market Price or Volume Weighted Average Price, such adjustments (if any) shall be made and as the Calculation Agent or an Independent Adviser considers appropriate to reflect any consolidation or sub-division of the Shares or any issue of Shares by way of capitalisation of profits or reserves, or any like or similar event.

For the purposes of Conditions 6.1 (*Conversion Period and Conversion Price*), 6.2 (*Adjustment of Conversion Price*), 6.3 (*Retroactive Adjustments*), 6.9 (*Procedure for exercise of Conversion Rights*), 6.11 (*Ranking and entitlement*), 9.9 (*Share Settlement Option*) and 11 (*Undertakings*) only, (i) references to the "**issue**" of Shares or Shares being "**issued**" shall include the transfer and/or delivery of Shares, whether newly issued and allotted or previously existing or held by or on behalf of the Issuer or any of its Subsidiaries, and (ii) Shares held by or on behalf of the Issuer or any of its Subsidiaries (and which, in the case of Condition 6.2(d) (*Rights issues*) and 6.2(f) (*Issue of Securities to Shareholders*), do not rank for the relevant right or other entitlement) shall not be considered as or treated as "**in issue**" or "**issued**", or entitled to receive the relevant Dividend, right or other entitlement.

For the purposes of these Conditions, at all times each Bond (and the principal amount outstanding thereunder) shall be treated equally and as a single series for the purposes of calculating any percentage of the principal amount outstanding of Bonds (including, without limitation, for the purposes of determining any matters that requires the approval of the Bondholders or the Majority Bondholders or in relation to Conditions 11 (*Undertakings*) or 15 (*Amendment and Waiver*)).

**4.** **Registration and Transfer of Bonds**

**4.1** **Registration**

The Issuer will keep or will cause to be kept a Register as provided in Clause 4 (*Register and Title*) of the Bond Instrument.

**4.2** **Transfer**

Bonds may be transferred in accordance with the provisions of Clauses 4 (*Register and Title*) and 6 (*Transfer of Rights and Obligations*) of the Bond Instrument.

**5.** **Interest**

**5.1** **Interest Rate**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Interest Rate

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

The Bonds bear interest from (and including) the Issue Date at the rate of 6.50 per cent. per annum (the "**Rate of Interest**") payable in arrear on each three-month anniversary date of the Concurrent Equity Raise (being 18 February, 18 May, 18 August and 18 November of each year) (each such date, an "**Interest Payment Date**), with the first Interest Payment Date falling on 18 February 2026 and with the final Interest Payment Date falling on the Original Final Maturity Date.

The amount of interest payable per each Bond in respect of any period (the "**Accrual Period**") which is, or is shorter than, an Interest Period (including, without limitation, interest payable on any Interest Payment Date, and interest payable in respect of an Advanced Amortised Payment Amount on an Advanced Amortisation Payment Date) shall be calculated by the Calculation Agent as the product (rounded to the nearest whole multiple of €0.01 (with €0.005 being rounded upwards)) of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the outstanding principal amount of such Bond (or, in the case of interest payable in respect of an Advanced Amortised Payment Amount on an Advanced Amortisation Payment Date, such Advanced Amortised Payment Amount);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the Rate of Interest; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) the applicable day count fraction determined in accordance with the Actual/Actual (ICMA) day count convention, being:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) where such Accrual Period is an Interest Period (other than the first Interest Period): 0.25; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) where such Accrual Period is the first Interest Period: a fraction, the numerator of which is the number of days in such first Interest Period and the denominator of which is the product of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) 92; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) 4, being the number of Interest Periods normally ending in any year;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(C) where such Accrual Period is shorter than an Interest Period, a fraction, the numerator of which is the number of days in such Accrual Period and the denominator of which is the product of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) the number of days in the Interest Period in which such Accrual Period falls (or, if such Interest Period is the first Interest Period, 92); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) 4, being the number of Interest Periods normally ending in any year.

For the avoidance of doubt, in circumstances where an Advanced Amortised Payment Date has occurred in respect of any Bond in an Interest Period, the relevant Advanced Amortisation Payment shall be ignored for the purposes of calculating the interest payable on the relevant Bond on the Interest Payment Date immediately following such Interest Period (so as to avoid any double counting in respect of interest paid in respect of such Advanced Amortisation Payment on such Advanced Amortised Payment Date).

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

"**Interest Period**" means the period beginning on (and including) the Issue Date and ending on (but excluding) the first Interest Payment Date and each successive period beginning on (and including) an Interest Payment Date and ending on (but excluding) the next succeeding Interest Payment Date.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Interest Share Settlement Option Notice

In respect of any interest payment due on an Interest Payment Date (or an Advanced Amortisation Payment Date), such interest payment shall be paid by the Issuer in cash unless, subject to Condition 9.9(d) (*Annulment of Share Settlement Option*), the Issuer elects (in its sole discretion) to exercise the Share Settlement Option pursuant to and in accordance with Condition 9.9 (*Share Settlement Option*) in respect of all but not some only of the Bonds by giving notice thereof (an "**Interest Share Settlement Option Notice**") (which notice shall be irrevocable) to Bondholders in accordance with Condition 16 (*Notices*) by no later than 5:00 p.m. New York time on the third Qualifying Business Day prior to such Interest Payment Date (or, in the case of any interest payment due on an Advanced Amortisation Payment Date, by no later than 5:00 p.m. New York time on the third Qualifying Business Day prior to such Advanced Amortisation Payment Date).

**5.2** **Accrual of Interest**

Each Bond will cease to bear interest:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) where the Conversion Right shall have been exercised by a Bondholder from (and including) the Interest Payment Date immediately preceding the relevant Conversion Date or, if none, the Issue Date (subject in any such case as provided in Condition 6.12 (*Interest on Conversion*)); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) where such Bond is redeemed or repaid pursuant to Condition 7 (*Redemption of Bonds*) or Condition 10 (*Events of Default*), from (and including) the due date for redemption or repayment thereof (which shall be, for the avoidance of doubt, in respect of any principal due on any Amortisation Payment Date (including, for the avoidance of doubt, any Advanced Amortisation Payment Date) in respect of which a Share Settlement applies, such Amortisation Payment Date) unless payment of principal is improperly withheld or refused or, following any election to exercise the Share Settlement Option, the Issuer fails duly to perform its obligations to issue or transfer and deliver the relevant Deliverable Shares in accordance with Condition 9.9 (*Share Settlement Option*) in which event interest will continue to accrue at the rate specified in Condition 5.1 (*Interest Rate*) (both before and after judgment) to (but excluding) the Relevant Date or, as the case may be, the date on which such issue and delivery of Deliverable Shares is duly made in accordance with Condition 9.9 (*Share Settlement Option*).

**5.3** **Default Interest**

If the Issuer fails to pay any amount payable by it on its due date, default interest shall accrue on the overdue amount from (and including) the due date up to (but excluding) the date of actual payment at a rate which is two per cent. higher than the Rate of Interest. Accrued default interest shall not be capitalised.

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**6.** **Conversion of Bonds**

**6.1** **Conversion Period and Conversion Price**

Subject to and as provided in these Conditions, each Bond in the original principal amount of €100,000 shall entitle the holder to convert the whole of the then outstanding principal amount of such Bond into new and/or existing Share(s) as determined by the Issuer, credited as fully paid (a "**Bond Conversion Right**").

Subject to and as provided in these Conditions, each Bond shall entitle the holder to contribute in kind in the Issuer its receivable for the amount of the relevant Amortised Payment Amount (including, for the avoidance of doubt, any Advanced Amortised Payment Amount) that would be payable on the next following Amortisation Payment Date (including, for the avoidance of doubt, any Advanced Amortisation Payment Date) in respect of such Bond (any such Amortised Payment Amount (including, for the avoidance of doubt, any Advanced Amortised Payment Amount), an "**Upcoming Amortised Payment Amount**" in respect of such Bond) against issuance of new Share(s), credited as fully paid (the "**Amortisation Conversion Right**" and together with the Bond Conversion Right the "**Conversion Rights**").

The number of Shares to be issued or transferred and delivered on exercise of a Conversion Right shall be equal to the Reference Shares in respect of such exercise, subject to Condition 6.3 (*Retroactive Adjustments*).

The Conversion Price per Share is initially €5.00 (the "**Initial Conversion Price**"). The Conversion Price is subject to adjustment in the circumstances described in Condition 6.2 (*Adjustment of Conversion Price*) and Condition 6.4 (*Conversion Price Reset*). The expression "**Conversion Price**" shall be construed accordingly.

Subject to and as provided in these Conditions (including, without limitation, Condition 6.9 (*Procedure for exercise of Conversion Rights*)), the Conversion Right in respect of a Bond (including the right to convert any Upcoming Amortised Payment Amounts in respect thereof) may be exercised, at the option of the holder thereof, at any time subject to any applicable fiscal or other laws or regulations and as hereinafter provided from (and including) the Issue Date to (and including) the date falling two Qualifying Business Days prior to the Final Maturity Date (or, in the case of the right to convert any Upcoming Amortised Payment Amount, to (and including) the date falling one Qualifying Business Day prior to the Amortisation Payment Date in relation to such Upcoming Amortised Payment Amount), unless there shall be a default in making payment in respect of such Bond on any such date fixed for redemption, in which event the Conversion Right shall extend up to (and including) the date on which the full amount of such payment becomes available for payment and notice of such availability has been given to Bondholders or, if earlier, the Final Maturity Date; *provided that*, in each case, if such final date for the exercise of Conversion Rights is not a Qualifying Business Day, then the period for exercise of Conversion Rights by Bondholders shall end on (and including) the immediately preceding Qualifying Business Day.

The period during which Conversion Rights may (subject as provided below) be exercised by a Bondholder is referred to as the "**Conversion Period**".

Conversion Rights shall expire immediately upon the commencement of liquidation, bankruptcy, insolvency or other analogous proceedings relating to the Issuer, dissolution of the Issuer or removal from the Belgian Crossroads Bank for Enterprises of the Issuer.

Fractions of Shares will not be issued or transferred and delivered on exercise of Conversion Rights or pursuant to Condition 6.3 (*Retroactive Adjustments*) and no cash payment or other adjustment

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will be made in lieu thereof. However, if the Conversion Right in respect of more than one Bond (or any Upcoming Amortised Payment Amounts that would be payable on more than one Bond, as the case may be) is exercised at any one time such that Shares to be issued or transferred and delivered on conversion or pursuant to Condition 6.3 (*Retroactive Adjustments*) are to be registered in the same name, the number of such Shares to be issued or transferred and delivered in respect thereof shall, in accordance with the definition of 'Reference Shares', be calculated by the Calculation Agent on the basis of the aggregate principal amount of such Bonds (or aggregate amount of the relevant Upcoming Amortised Payment Amounts, as the case may be) being so converted and rounded down to the nearest whole number of Shares.

Conversion Rights may not be exercised (i) following the giving of notice by the holders of at least one-quarter in principal amount of the Bonds then outstanding pursuant to Condition 10 (*Events of Default*); (ii) in respect of a Bond in respect of which the relevant holder has exercised its right to require the Issuer to redeem pursuant to Condition 7.2 (*Redemption at the Option of Bondholders (Relevant Event*)) (but without prejudice to the rights of Bondholders to require the Issuer to issue or transfer and deliver Shares as provided therein); or (iii) on any Interest Payment Date or Amortisation Payment Date or the dealing day immediately prior to such date.

Subject to the right of the Issuer to make a Cash Alternative Election (which shall be exercisable solely in the event and to the extent that the issue and delivery of Shares in respect of any exercise of Conversion Rights would cause the issue, conversion or delivery of more Shares than permitted by applicable law pursuant to Condition 12 (*Regulatory Share Cap*)), the Issuer will procure that Shares to be issued or transferred and delivered on exercise of Conversion Rights will be issued or transferred and delivered to, or to the order of, the person or persons specified in the relevant Payment Details by the relevant Bondholder in accordance with the provisions of Condition 6.9 (*Procedure for exercise of Conversion Rights*). Such Shares (other than Additional Shares) will be deemed to be issued or transferred and delivered as of the relevant Registration Date and the Issuer shall procure that such Registration Date shall occur as soon as practicable after the relevant Conversion Date (and in any event no later than the relevant Scheduled Delivery Date in respect of such Shares). Any Additional Shares to be issued or transferred and delivered pursuant to Condition 6.3 (*Retroactive Adjustments*) will be deemed to be issued or transferred and delivered as of the relevant Additional Registration Date and the Issuer shall procure that such Additional Registration Date shall occur as soon as practicable after the relevant Reference Date (and in any event no later than the relevant Scheduled Delivery Date in respect of such Additional Shares).

**6.2** **Adjustment of Conversion Price**

Subject to the provisions of this Condition 6 (*Conversion of Bonds*), upon the occurrence of any of the events described below (other than where the Applicable Adjustment Record Date in respect thereof falls prior to the Issue Date), the Conversion Price shall be adjusted by the Calculation Agent as follows:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Consolidation, reclassification, redesignation or subdivision

If and whenever there shall be a consolidation, reclassification, redesignation or subdivision affecting the number of Shares in issue, the Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately prior to the Effective Date by the following fraction:

A

—

B

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where:

A is the aggregate number of Shares in issue immediately before such consolidation, reclassification, redesignation or subdivision, as the case may be; and

B is the aggregate number of Shares in issue immediately after, and as a result of, such consolidation, reclassification, redesignation or subdivision, as the case may be.

Such adjustment shall become effective on the Effective Date.

"**Effective Date**" means, in respect of this Condition 6.2(a), the date on which the consolidation, reclassification, redesignation or sub-division, as the case may be, takes effect (or, if later, the Brussels and New York business day falling immediately after the record date or other due date for the establishment of entitlement in respect thereof).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Capitalisation of profits or reserves

If and whenever the Issuer shall issue any Shares to the Shareholders by way of capitalisation of profits or reserves (including any share premium account or capital redemption reserve) other than where such issue of Shares constitutes a Scrip Dividend, the Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately prior to the Effective Date by the following fraction:

A

—

B

where:

A is the aggregate number of Shares in issue immediately before such issue; and

B is the aggregate number of Shares in issue immediately after such issue.

Such adjustment shall become effective on the Effective Date.

"**Effective Date**" means, in respect of this Condition 6.2(b), the date of issue of such Shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Dividends

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) If and whenever the Ex-Date of a Dividend shall occur, the Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately prior to the Effective Date by the following fraction:

A – B

——

A

where:

A is the Current Market Price of one Share on the Ex-Date in respect of such Dividend; and

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| | |
|:---|:---|
| B | is the portion of the Fair Market Value of the aggregate Dividend attributable to one Share, with such portion being determined by dividing the Fair Market Value of the aggregate Dividend by the number of Shares entitled to receive the relevant Dividend (or, in the case of a purchase, redemption or buy back of Shares or any depositary or other receipts or certificates representing Shares by or on behalf of the Issuer or any Subsidiary of the Issuer, by the number of Shares in issue immediately following such purchase, redemption or buy back, and treating as not being in issue any Shares, or any Shares represented by depositary or other receipts or certificates, purchased, redeemed or bought back). |

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Such adjustment shall become effective on the Effective Date.

"**Effective Date**" means, in respect of this Condition 6.2(c), the later of (A) the first Brussels and New York business day on which the Fair Market Value of the relevant Dividend is capable of being determined as provided herein, and (B) the Brussels and New York business day falling immediately after the record date or other due date for the establishment of entitlement in respect of such Dividend.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) For the purposes of the above, Fair Market Value shall (subject as provided in the definition of "Dividend" and in the definition of "Fair Market Value") be determined as at the Ex-Date in respect of the relevant Dividend.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) Rights issues

If and whenever the Issuer or any Subsidiary of the Issuer or (at the direction or request or pursuant to any arrangements with the Issuer or any Subsidiary of the Issuer) any other company, person or entity shall issue any Shares to Shareholders as a class by way of rights, or shall issue or grant to Shareholders as a class by way of rights, any options, warrants or other rights to subscribe for or purchase or otherwise acquire any Shares, or any other Securities which by their terms of issue carry (directly or indirectly) rights of conversion into, or exchange or subscription for, or the right to otherwise acquire, any Shares (or shall grant any such rights in respect of existing Securities so issued), in each case at a consideration receivable per Share (based, where appropriate, on such number of Shares as is determined pursuant to the definition of "C" and the proviso below) which is less than 95 per cent. of the Current Market Price per Share on the Ex-Date in respect of the relevant issue or grant, the Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately prior to the Effective Date by the following fraction:

A+B

——

A+C

where:

A is the number of Shares in issue on such Ex-Date;

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| | |
|:---|:---|
| B | is the number of Shares which the aggregate consideration (if any) receivable for the Shares issued by way of rights, or for the Securities issued by way of rights and upon exercise of rights of conversion into, or exchange or subscription for, or the right to otherwise acquire, Shares, or for the options or warrants or other rights issued by way of rights and for the total number of Shares deliverable on |

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the exercise thereof, would purchase at such Current Market Price per Share on the Ex-Date; and

C is the number of Shares to be issued or, as the case may be, the maximum number of Shares which may be issued upon exercise of such options, warrants or rights calculated as at the date of issue of such options, warrants or rights or upon conversion or exchange or exercise of rights of subscription or purchase or other rights of acquisition in respect thereof at the initial conversion, exchange, subscription, purchase or acquisition price or rate;

provided that if on such Ex-Date such number of Shares is to be determined by reference to the application of a formula or other variable feature or the occurrence of any event at some subsequent time, then for the purposes of this Condition 6.2(d), "C" shall be determined by the application of such formula or variable feature or as if the relevant event occurs or had occurred as at such Ex-Date and as if such conversion, exchange, subscription, purchase or acquisition had taken place on such Ex-Date.

Such adjustment shall become effective on the Effective Date.

"**Effective Date**" means, in respect of this Condition 6.2(d), the later of (A) the first Brussels and New York business day on which the adjusted Conversion Price is capable of being determined in accordance with this Condition 6.2(d), and (B) the Brussels and New York business day falling immediately after the record date or other due date for the establishment of entitlement in respect of the relevant issue or grant.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) Issue of Securities to Shareholders

If and whenever the Issuer or any Subsidiary of the Issuer or (at the direction or request or pursuant to any arrangements with the Issuer or any Subsidiary of the Issuer) any other company, person or entity shall (other than in the circumstances the subject of Condition 6.2(d) above and other than constituting a Scrip Dividend) issue any Securities to Shareholders as a class by way of rights or grant to Shareholders as a class by way of rights any options, warrants or other rights to subscribe for or purchase or otherwise acquire any Securities, the Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately prior to the Effective Date by the following fraction:

A – B

——

A

where:

A is the Current Market Price of one Share on the Ex-Date in respect of the relevant issue or grant; and

B is the Fair Market Value on such Ex-Date of the portion of the rights attributable to one Share.

Such adjustment shall become effective on the Effective Date.

"**Effective Date**" means, in respect of this Condition 6.2(e), the later of (A) the first Brussels and New York business day on which the adjusted Conversion Price is capable of being determined in accordance with this Condition 6.2(e), and (B) the Brussels and New

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York business day falling immediately after the record date or other due date for the establishment of entitlement in respect of the relevant issue or grant.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) Issue of Shares at below Current Market Price

If and whenever the Issuer shall issue (otherwise than as mentioned in Condition 6.2(d) above) wholly for cash or for no consideration any Shares (other than Shares issued on conversion of, or pursuant to any exercise of the Share Settlement Option under, the Bonds (which term shall for this purpose include any Further Bonds) or on the exercise of any rights of conversion into, or exchange or subscription for or purchase of, or rights to otherwise acquire, Shares and other than constituting a Scrip Dividend) or if and whenever the Issuer or any Subsidiary of the Issuer or (at the direction or request or pursuant to any arrangements with the Issuer or any Subsidiary of the Issuer) any other company, person or entity shall issue or grant (otherwise than as mentioned in Condition 6.2(d) above) wholly for cash or for no consideration any options, warrants or other rights to subscribe for or purchase or otherwise acquire any Shares (other than the Bonds, which term shall for this purpose include any Further Bonds), in each case at consideration receivable per Share (based, where appropriate, on such number of Shares as is determined pursuant to the definition of "C" and the proviso below) which is less than 95 per cent. of the Current Market Price per Share on the date of first public announcement of the terms of such issue or grant, the Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately prior to the Effective Date by the following fraction:

A+B

——

A+C

where:

A is the number of Shares in issue immediately before the date of first public announcement of the terms of such issue of Shares or issue or grant of options, warrants or other rights as provided above;

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| | |
|:---|:---|
| B | is the number of Shares which the aggregate consideration (if any) receivable for the issue of such Shares or, as the case may be, for the Shares to be issued or otherwise made available upon the exercise of any such options, warrants or rights, would purchase at such Current Market Price per Share on the date of first public announcement of the terms of such issue or grant; and |

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C is the number of Shares to be issued pursuant to such issue of such Shares or, as the case may be, the maximum number of Shares which may be issued upon exercise of such options, warrants or rights calculated as at the date of issue of such options, warrants or rights;

provided that if on the date of first public announcement of the terms of such issue or grant (as used in this Condition 6.2(f), the "**Specified Date**") such number of Shares is to be determined by reference to the application of a formula or other variable feature or the occurrence of any event at some subsequent time, then for the purposes of this Condition 6.2(f), "C" shall be determined by the application of such formula or variable feature or as if the relevant event occurs or had occurred as at the Specified Date and as if such conversion, exchange, subscription, purchase, acquisition had taken place on the Specified Date.

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Such adjustment shall become effective on the Effective Date.

"**Effective Date**" means, in respect of this Condition 6.2(f), the later of (A) the date of issue of such Shares or, as the case may be, the issue or grant of such options, warrants or rights, and (B) the first Brussels and New York business day on which the adjusted Conversion Price is capable of being determined in accordance with this Condition 6.2(f).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) Other issues

If and whenever the Issuer or any Subsidiary of the Issuer or (at the direction or request of or pursuant to any arrangements with the Issuer or any Subsidiary of the Issuer) any other company, person or entity shall (otherwise than as mentioned in Conditions 6.2(d), (e) or (f) above) issue wholly for cash or for no consideration any Securities (other than the Bonds which term shall for this purpose exclude any Further Bonds and other than constituting a Scrip Dividend) which by their terms of issue carry (directly or indirectly) rights of conversion into, or exchange or subscription for, purchase of, or rights to otherwise acquire, Shares (or shall grant any such rights in respect of existing Securities so issued) or Securities which by their terms might be reclassified or redesignated as Shares, and the consideration per Share (based, where appropriate, on such number of Shares as is determined pursuant to the definition of "C" and the proviso below) receivable upon conversion, exchange, subscription, purchase, acquisition, reclassification or redesignation is less than 95 per cent. of the Current Market Price per Share on the date of first public announcement of the terms of the issue of such Securities (or the terms of such grant), the Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately prior to the Effective Date by the following fraction:

A+B

——

A+C

where:

A is the number of Shares in issue immediately before the date of first public announcement of the terms of the issue of such Securities (or the terms of such grant);

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| | |
|:---|:---|
| B | is the number of Shares which the aggregate consideration (if any) receivable for the Shares to be issued or otherwise made available upon conversion or exchange or upon exercise of the right of subscription, purchase or acquisition attached to such Securities or, as the case may be, for the Shares to be issued or to arise from any such reclassification or redesignation would purchase at such Current Market Price per Share on the date of first public announcement of the terms of the issue of such Securities (or the terms of such grant); and |

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C is the maximum number of Shares to be issued or otherwise made available upon conversion or exchange of such Securities or upon the exercise of such right of subscription, purchase or acquisition attached thereto at the initial conversion, exchange, subscription, purchase or acquisition price or rate or, as the case may be, the maximum number of Shares which may be issued or arise from any such reclassification or redesignation;

provided that if on the date of first public announcement of the terms of the issue of such Securities (or the terms of such grant) (as used in this Condition 6.2(g), the "**Specified** 

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**Date**") such number of Shares is to be determined by reference to the application of a formula or other variable feature or the occurrence of any event at some subsequent time (which may be when such Securities are converted or exchanged or rights of subscription, purchase or acquisition are exercised or, as the case may be, such Securities are reclassified or redesignated or at such other time as may be provided), then for the purposes of this Condition 6.2(g), "C" shall be determined by the application of such formula or variable feature or as if the relevant event occurs or had occurred as at the Specified Date and as if such conversion, exchange, subscription, purchase or acquisition, reclassification or, as the case may be, redesignation had taken place on the Specified Date.

Such adjustment shall become effective on the Effective Date.

"**Effective Date**" means, in respect of this Condition 6.2(g), the later of (A) the date of issue of such Securities or, as the case may be, the grant of such rights, and (B) the first Brussels and New York business day on which the adjusted Conversion Price is capable of being determined in accordance with this Condition 6.2(g).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) Modification of rights

If and whenever there shall be any modification of the rights of conversion, exchange, subscription, purchase or acquisition attaching to any Securities (other than the Bonds, which term shall for this purpose include any Further Bonds) which by their terms of issue carry (directly or indirectly) rights of conversion into, or exchange or subscription for, or the right to otherwise acquire, any Shares (other than in accordance with the terms (including terms as to adjustment) applicable to such Securities upon issue) so that following such modification the consideration per Share (based, where appropriate, on such number of Shares as is determined pursuant to the definition of "C" and the proviso below) receivable upon conversion, exchange, subscription, purchase or acquisition has been reduced and is less than 95 per cent. of the Current Market Price per Share on the date of first public announcement of the terms for such modification, the Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately prior to the Effective Date by the following fraction:

A+B

——

A+C

where:

A is the number of Shares in issue immediately before the date of first public announcement of the terms for such modification;

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|:---|:---|
| B | is the number of Shares which the aggregate consideration (if any) receivable for the Shares to be issued or otherwise made available upon conversion or exchange or upon exercise of the right of subscription, purchase or acquisition attached to the Securities so modified would purchase at such Current Market Price per Share on the date of first public announcement of the terms for such modification or, if lower, the existing conversion, exchange, subscription, purchase or acquisition price or rate of such Securities; and |

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C is the maximum number of Shares which may be issued or otherwise made available upon conversion or exchange of such Securities or upon the exercise of such rights of subscription, purchase or acquisition attached thereto at the

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modified conversion, exchange, subscription, purchase or acquisition price or rate but giving credit in such manner as the Calculation Agent shall consider appropriate for any previous adjustment under this Condition 6.2(h) or Condition 6.2(g) above;

provided that if on the date of first public announcement of the terms of such modification (as used in this Condition 6.2(h), the "**Specified Date**") such number of Shares is to be determined by reference to the application of a formula or other variable feature or the occurrence of any event at some subsequent time (which may be when such Securities are converted or exchanged or rights of subscription, purchase or acquisition are exercised or at such other time as may be provided), then for the purposes of this Condition 6.2(h), "C" shall be determined by the application of such formula or variable feature or as if the relevant event occurs or had occurred as at the Specified Date and as if such conversion, exchange, subscription, purchase or acquisition had taken place on the Specified Date.

Such adjustment shall become effective on the Effective Date.

"**Effective Date**" means, in respect of this Condition 6.2(h), the later of (A) the date of modification of the rights of conversion, exchange, subscription, purchase or acquisition attaching to such Securities, and (B) the first Brussels and New York business day on which the adjusted Conversion Price is capable of being determined in accordance with this Condition 6.2(h).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) Certain arrangements

If and whenever the Issuer or any Subsidiary of the Issuer or (at the direction or request of or pursuant to any arrangements with the Issuer or any Subsidiary of the Issuer) any other company, person or entity shall offer any Shares or such other Securities in connection with which Shareholders as a class are entitled to participate in arrangements whereby such Shares or Securities may be acquired by them (except where the Conversion Price falls to be adjusted under Conditions 6.2(b), (c), (d), (e), (f), or (g) above or (j) below (or, where applicable, would fall to be so adjusted if the relevant issue or grant was at less than 95 per cent. of the Current Market Price per Share on the relevant day)), the Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately prior to the Effective Date by the following fraction:

A – B

——

A

where:

A is the Current Market Price of one Share on the Ex-Date in respect of the relevant offer; and

B is the Fair Market Value on such Ex-Date of the portion of the relevant offer attributable to one Share.

Such adjustment shall become effective on the Effective Date.

"**Effective Date**" means, in respect of this Condition6.2(i), the later of (A) the first Brussels and New York business day on which the adjusted Conversion Price is capable of being determined in accordance with this Condition 6.2(i), and (B) the Brussels and New York

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business day falling immediately after the record date or other due date for the establishment of entitlement in respect of the relevant offer.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(j) Relevant Event

Subject as provided in the final paragraph of this Condition 6.2(j), if a Relevant Event shall occur, then, upon any exercise of Conversion Rights where the Conversion Date falls during the Relevant Event Period in respect of such Relevant Event, the Conversion Price solely for the purpose of such exercise (the "**Relevant Event Conversion Price**") shall be determined as set out below:

![Graphic](nyxh-20251231xex4d22003.jpg)

where:

RECPis the Relevant Event Conversion Price

OCPis the Conversion Price in effect on the relevant Conversion Date

CP=25 per cent.

c is the number of days from and including the date the Relevant Event occurs to but excluding the Original Final Maturity Date

t is the number of days from and including the Issue Date to but excluding the Original Final Maturity Date

In the case of a Change of Control, the foregoing provisions of this Condition 6.2(j) will only become effective if and when the Change of Control Resolutions are approved and filed with the clerk's office of the competent Enterprise Court in accordance with the provisions of the Belgian Companies and Associations Code.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(k) Other adjustments

Subject to Condition 6.6 (*Employee Incentive Issuances*), if either the Issuer (following consultation with the Calculation Agent) or the Majority Bondholders (each acting reasonably) determines that an adjustment (for the purpose of compensating for dilution) should be made to the Conversion Price (or that a determination should be made as to whether an adjustment should be made) as a result of one or more circumstances not referred to above in this Condition 6.2 (*Adjustment of Conversion Price*) (except for events specifically excluded from the operation of Conditions 6.2(a) to (j) above), the Issuer shall, at its own expense and acting reasonably, request an Independent Adviser to determine, in consultation with the Calculation Agent, if different, as soon as practicable what adjustment (if any) to the Conversion Price is fair and reasonable to take account thereof and the date on which such adjustment (if any) should take effect and upon such determination such adjustment (if any) shall be made and shall take effect in accordance with such determination, provided that an adjustment shall only be made pursuant to this Condition 6.2(k) if such Independent Adviser is so requested to make such a determination not more than 21 days after the date on which the relevant circumstances arises (or, if later, 21 days after the date on which the relevant circumstances are made public or otherwise are made known to the Bondholders) and if the adjustment would result in a reduction to the Conversion Price.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(l) Modifications

Notwithstanding the foregoing provisions:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) where the events or circumstances giving rise to any adjustment pursuant to this Condition 6.2 (*Adjustment of Conversion Price*) have already resulted or will result in an adjustment to the Conversion Price or where the events or circumstances giving rise to any adjustment arise by virtue of any other events or circumstances which have already given or will give rise to an adjustment to the Conversion Price or where more than one event which gives rise to an adjustment to the Conversion Price occurs within such a short period of time that, in the opinion of the Issuer (acting reasonably) and following consultation with the Calculation Agent, a modification to the operation of the adjustment provisions is required to give the intended result, such modification shall be made to the operation of the adjustment provisions as may be determined by an Independent Adviser to be in its opinion appropriate to give the intended result;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) such modification shall be made to the operation of these Conditions as may be determined by an Independent Adviser, in consultation with the Calculation Agent (if different), to be in its opinion appropriate (A) to ensure that an adjustment to the Conversion Price or the economic effect thereof shall not be taken into account more than once and (B) to ensure that the economic effect of a Dividend is not taken into account more than once; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) other than pursuant to Condition 6.2(a) (*Consolidation, reclassification, redesignation or subdivision*), no adjustment shall be made that would result in an increase to the Conversion Price.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(m) Calculation of consideration

For the purpose of any calculation of the consideration receivable or price pursuant to Conditions 6.2(d), (f), (g) and (h) above, the following provisions shall apply:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the aggregate consideration receivable or price for Shares issued for cash shall be the amount of such cash;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) (x) the aggregate consideration receivable or price for Shares to be issued or otherwise made available upon the conversion or exchange of any Securities shall be deemed to be the consideration or price received or receivable for any such Securities (whether on one or more occasions) and (y) the aggregate consideration receivable or price for Shares to be issued or otherwise made available upon the exercise of rights of subscription attached to any Securities or upon the exercise of any options, warrants or rights shall be deemed to be that part (which may be the whole) of the consideration or price received or receivable for such Securities or, as the case may be, for such options, warrants or rights which are attributed by the Issuer to such rights of subscription or, as the case may be, such options, warrants or rights or, if no part of such consideration or price is so attributed, the Fair Market Value of such rights of subscription or, as the case may be, such options, warrants or rights as at the relevant Ex-Date referred to in Condition 6.2(d) above or as at the relevant date of first public announcement referred to in Conditions 6.2(f), (g) and (h) above, as the case may be, plus in the case of each of (x) and (y) above in this paragraph, the additional minimum consideration receivable or price (if any) upon the conversion or exchange of such Securities, or upon the exercise of such

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rights of subscription attached thereto or, as the case may be, upon exercise of such options, warrants or rights and (z) the consideration receivable or price per Share upon the conversion or exchange of, or upon the exercise of such rights of subscription attached to, such Securities or, as the case may be, upon the exercise of such options, warrants or rights shall be the aggregate consideration or price referred to in (x) or (y) above in this paragraph (as the case may be) divided by the number of Shares to be issued upon such conversion or exchange or exercise at the initial conversion, exchange or subscription price or rate, all as determined by the Calculation Agent;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) if the consideration or price determined pursuant to (i) or (ii) above (or any component thereof) shall be expressed in a currency other than the Relevant Currency (other than in circumstances where such consideration is also expressed in the Relevant Currency, in which case such consideration shall be treated as expressed in the Relevant Currency in an amount equal to the amount of such consideration when so expressed in the Relevant Currency), it shall be converted by the Calculation Agent into the Relevant Currency at the Prevailing Rate on the relevant Ex-Date (for the purposes of Condition 6.2(d) above) or the relevant date of first public announcement (for the purposes of Conditions 6.2(f), (g) and (h) above, as the case may be);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) in determining the consideration or price pursuant to the above, no deduction shall be made for any commissions or fees (howsoever described) or any expenses paid or incurred for any underwriting, placing or management of the issue of the relevant Shares or such other Securities or options, warrants or rights, or otherwise in connection therewith;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) the consideration or price shall be determined as provided above on the basis of the consideration or price received, receivable, paid or payable, regardless of whether all or part thereof is received, receivable, paid or payable by or to the Issuer or another entity;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) if as part of the same transaction, Shares shall be issued or issuable for a consideration receivable in more than one or in different currencies then the consideration receivable per Share shall be determined by dividing the aggregate consideration (determined as aforesaid and converted, if and to the extent not in the Relevant Currency, into the Relevant Currency as aforesaid) by the aggregate number of Shares so issued; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) references in these Conditions to "cash" includes any promise or undertaking to pay cash or any release or extinguishment of, or set-off against, a liability or obligation to pay a cash amount.

**6.3** **Retroactive Adjustments**

If a Retroactive Adjustment occurs in relation to any exercise of Conversion Rights (other than where there are no Physically Settled Shares in respect of such exercise of Conversion Rights), the Issuer shall procure that there shall be issued or transferred and delivered to, or to the order of, the relevant Bondholder and in accordance with the Payment Details, such additional number of Shares (if any) (the "**Additional Shares**") as, together with the Physically Settled Shares issued or transferred and delivered in the relevant exercise of Conversion Rights, is equal to the number of Physically Settled Shares which would have been required to be issued or transferred and delivered on such exercise and subsequent exchange if the relevant adjustment to the Conversion Price had

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been made and become effective immediately prior to the relevant Conversion Date (such number of Physically Settled Shares as aforesaid being for this purpose calculated as:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) where such exercise of Conversion Rights is not the subject of a Cash Alternative Election, the Reference Shares in respect of such exercise of Conversion Rights determined for this purpose by reference to such deemed Conversion Price as aforesaid; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) where such exercise of Conversion Rights is the subject of a Cash Alternative Election, the difference between:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) such number of Reference Shares as is determined pursuant to paragraph (a); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the product of (x) such number of Reference Shares determined as aforesaid and (y) the Cash Settlement Ratio in respect of such exercise of Conversion Rights),

all as determined by the Calculation Agent or an Independent Adviser, *provided that* if in the case of Conditions 6.2(b), 6.2(c), 6.2(d), 6.2(e) or 6.2(i) the relevant Bondholder shall be entitled to receive the relevant Shares, Dividends or such other Securities in respect of the Reference Shares to be issued and/or transferred and delivered to it, then the relevant Bondholder shall not be entitled to receive Additional Shares in relation to such Retroactive Adjustment.

**6.4** **Conversion Price Reset**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Subject to the paragraph (b) below, in the event of any Qualifying Equity Raise (whether on one or more occasions) completed by the Issuer or any Subsidiary of the Issuer or any of their respective affiliates at any time from (and including) the Issue Date, the Conversion Price will be adjusted on the date of completion of such Qualifying Equity Raise (or, if an adjustment to the Conversion Price is required to be made pursuant to Condition 6.2 (*Adjustment of Conversion Price*) in respect of such Qualifying Equity Raise, on the later of (i) the date on which such adjustment becomes effective, and (ii) the date of completion of such Qualifying Equity Raise) (the "**Equity Raise Reset Date**") by the Calculation Agent to be equal to the Placing Price in respect of such Qualifying Equity Raise.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) An adjustment to the Conversion Price in respect of a Qualifying Equity Raise pursuant to this Condition 6.4 *Conversion Price Reset*) (such adjustment, a "**Conversion Price Reset**") shall be made only if the Conversion Price so adjusted is lower than the Conversion Price that would, but for the operation of this Condition 6.4 (*Conversion Price Reset*), be in effect on the Equity Raise Reset Date.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Any adjustment to the Conversion Price pursuant to this Condition 6.4 (*Conversion Price Reset*) shall become effective as of the Equity Raise Reset Date (*provided that*, in the case of an adjustment to the Conversion Price in respect of a Qualifying Equity Raise pursuant to this Condition 6.4 (*Conversion Price Reset*), if an adjustment to the Conversion Price is required to be made pursuant to Condition 6.2 (*Adjustment of Conversion Price*) in respect of such Qualifying Equity Raise, the adjustment to the Conversion Price pursuant to this Condition 6.4 (*Conversion Price Reset*) shall be deemed to have occurred after such adjustment required to be made pursuant to Condition 6.2 (*Adjustment of Conversion Price*)) and notice of any such adjustment shall be given by the Issuer to Bondholders in accordance with Condition 16 (*Notices*).

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For the purposes of these Conditions:

"**Equity Raise**" means, other than in respect of an Exempt Transaction:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) any issuance of new Shares or any sale of existing Shares previously held by the Issuer or any Subsidiary or affiliate of the Issuer (in each case other than upon exercise of rights of conversion into, or exchange or subscription for, or the right to otherwise acquire, any Shares attached to any Equity-Linked Rights); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) any issuance of any other Securities (including without limitation warrants and options) or other right which by their terms of issue carry (directly or indirectly) rights of conversion into, or exchange or subscription for, or the right to otherwise acquire, any Shares (any such Securities or rights, "**Equity-Linked Rights** ").

"**Exempt Transaction**" means:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the issuance of any Excluded Instruments or the issuance of any Shares in connection with an exercise of any Excluded Instrument by the holder or beneficiary thereof; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) any LTIP Issuance or any Shares or other Equity-Linked Rights being issued, offered, exercised, allotted, purchased, appropriated, modified, granted or transferred pursuant to any LTIP Issuance, or any Shares or other Equity-Linked Rights upon any exercise of rights of conversion into, or exchange or subscription for, or the right to otherwise acquire, any Shares attached to any Equity-Linked Rights issued, offered, allotted or granted pursuant to any LTIP Issuance, where "**LTIP Issuance**" means any issuance, offer, allotment or grant of Shares or Equity-Linked Rights (in each case completed on or after the Issue Date) by the Issuer to, or for the benefit of, employees, officers and directors of the Issuer or any of its Subsidiaries and in each case pursuant to any employee incentive plans of the Issuer and/or its Subsidiaries, *provided that* such plans are duly approved by the Issuer's board of directors (including independent non-executive directors).

"**Placing Price**" means, in respect of any Qualifying Equity Raise, the Placing Proceeds in respect of such Qualifying Equity Raise divided by:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) (other than in the case of a Qualifying Equity Raise comprising the issuance of Equity-Linked Rights) the number of Shares comprised in such Qualifying Equity Raise; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) (in the case of a Qualifying Equity Raise comprising the issuance of Equity-Linked Rights) such number of Shares as is determined in a manner consistent with Conditions 6.2(d), 6.2(f) and 6.2(g) (as applicable),

in each case rounded down (if necessary) to the nearest whole multiple of €0.0001, as determined by the Issuer acting reasonably and in consultation with the Calculation Agent.

"**Placing Proceeds**" means, in respect of any Equity Raise:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) (other than in the case of an Equity Raise comprising the issuance of Equity-Linked Rights) the aggregate amount of the gross cash proceeds received by the Issuer (and/or any Subsidiary of the Issuer, or any of their respective affiliates) in respect of such Equity Raise; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) (in the case of an Equity Raise comprising the issuance of Equity-Linked Rights) the aggregate consideration receivable per Share determined in a manner consistent with Conditions 6.2(d), 6.2(f), 6.2(g) and 6.2(m) (as applicable),

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(in each case translated if necessary into EUR at the Prevailing Rate on the date of first public announcement of the terms of such Equity Raise) as determined by the Issuer acting reasonably and in consultation with the Calculation Agent.

"**Qualifying Equity Raise**" means any Relevant Equity Raise if the Placing Proceeds of such Relevant Equity Raise, together with the Placing Proceeds in respect of any other previous Relevant Equity Raise (disregarding for this purpose the entirety of any Relevant Equity Raise if any part or the entirety of such Relevant Equity Raise was previously taken into account in the determination of any previous Qualifying Equity Raise), are equal to or greater than €2 million, as determined by the Issuer acting reasonably and in consultation with the Calculation Agent.

"**Relevant Equity Raise**" means any Equity Raise the Placing Price in respect of which is lower than the Conversion Price in effect on the date of first public announcement of the terms of such Equity Raise.

**6.5** **Decision and Determination of the Calculation Agent or an Independent Adviser**

Adjustments to the Conversion Price shall be determined and calculated by the Calculation Agent upon request from the Issuer and/or, to the extent so specified in the Conditions and upon request from the Issuer, by an Independent Adviser.

Adjustments to the Conversion Price calculated by the Calculation Agent or, where applicable, an Independent Adviser and any other determinations made by the Calculation Agent or, where applicable, an Independent Adviser, or an opinion of an Independent Adviser, pursuant to these Conditions shall in each case be made in good faith and shall be final and binding (in the absence of manifest error) on the Issuer, the Bondholders and the Calculation Agent (in the case of a determination by an Independent Adviser).

The Calculation Agent may consult, at the expense of the Issuer, on any matter (including, but not limited to, any legal matter), any legal or other professional adviser and it shall be able to rely upon, and it shall not be liable and shall incur no liability as against the Bondholders in respect of anything done, or omitted to be done, relating to that matter in good faith in accordance with that adviser's opinion.

The Calculation Agent shall act solely upon the request from the Issuer, and shall act exclusively as agent of, the Issuer and in accordance with these Conditions. Neither the Calculation Agent (acting in such capacity) nor any Independent Adviser appointed in connection with the Bonds (acting in such capacity) will thereby assume any obligations towards or relationship of agency or trust and shall not be liable and shall incur no liability in respect of anything done, or omitted to be done in good faith, in its capacity as Calculation Agent, or as the case may be, Independent Adviser as against the Bondholders.

If following consultation between the Issuer and the Calculation Agent any doubt shall arise as to whether an adjustment falls to be made to the Conversion Price or as to the appropriate adjustment to the Conversion Price, following consultation between the Issuer and an Independent Adviser, a written opinion of such Independent Adviser in respect thereof shall be conclusive and binding on the Issuer, the Bondholders and the Calculation Agent (if different), save in the case of manifest error.

The Issuer shall promptly notify Bondholders in accordance with Condition 16 (*Notices*) of each determination, calculation or adjustment performed by the Calculation Agent and/or Independent Adviser pursuant to these Conditions.

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**6.6** **Exempt Transactions, Second Tranche Bonds and Concurrent Equity Raise**

Notwithstanding anything to the contrary in these Conditions, but without prejudice to Condition 6.4(a) (*Conversion Price Reset*), no adjustment will be made to the Conversion Price:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) in respect of any Shares issued and allotted pursuant to an Excluded Instrument;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) in respect of the issue of the Second Tranche Bonds (including, for the avoidance of doubt, any further bonds issued in accordance with the terms and conditions thereof) or any Shares issued and allotted pursuant to the exercise of conversion rights or any option similar to the Share Settlement Option under the Second Tranche Bonds; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) in respect of any Shares issued and allotted pursuant to the Concurrent Equity Raise.

**6.7** **Rounding Down and Notice of Adjustment to the Conversion Price**

On any adjustment, the resultant Conversion Price, if not a whole multiple of €0.0001, shall be rounded down to the nearest whole multiple of €0.0001.

Notice of any adjustments to the Conversion Price (and the resulting Minimum PMP) shall be given by the Issuer to Bondholders in accordance with Condition 16 (*Notices*) promptly after the determination thereof.

The Conversion Price shall not in any event be reduced so that, on conversion of the Bonds, Shares would fall to be issued in circumstances not permitted by applicable laws or regulations. The Issuer undertakes that it shall not take any action, and shall procure that no action is taken, that would otherwise result in an adjustment to the Conversion Price that would result in Shares being required to be issued or transferred and delivered in circumstances not permitted by applicable laws or regulations.

**6.8** **Relevant Event**

Within five Qualifying Business Days following the occurrence of a Relevant Event, the Issuer shall give notice thereof to Bondholders in accordance with Condition 16 (*Notices*) (a "**Relevant Event Notice**"). The Relevant Event Notice shall contain a statement informing Bondholders of (i) their entitlement to exercise their Conversion Rights as provided in these Conditions and (ii) their entitlement to exercise their rights to require redemption of their Bonds pursuant to Condition 7.2 (*Redemption at the Option of Bondholders (Relevant Event*). In the case of a Change of Control, the foregoing sentence shall be subject to the Change of Control Resolutions having been approved and filed in accordance with Article 7:151 of the Belgian Companies and Associations Code.

The Relevant Event Notice shall also specify, as applicable:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) if applicable, to the fullest extent permitted by applicable law, all information material to Bondholders concerning the Change of Control;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the nature of the Relevant Event;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) the Conversion Price immediately prior to the occurrence of the Relevant Event and, the Relevant Event Conversion Price applicable pursuant to Condition 6.2(j) (*Relevant Event*) on the basis of the Conversion Price in effect immediately prior to the occurrence of the Relevant Event;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) the Closing Price of the Shares as at the latest practicable date prior to the publication of the Relevant Event Notice;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) the Relevant Event Period; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) the Relevant Event Put Date.

**6.9** **Procedure for exercise of Conversion Rights**

Conversion Rights in respect of a Bond may be exercised by a Bondholder (provided that the relevant Conversion Date falls during the Conversion Period) by (i) in respect of the whole of such Bond, by delivering the relevant Bond Certificate together with a Conversion Notice to the Issuer and (ii) in respect of any Upcoming Amortised Payment Amount, by delivering a Conversion Notice to the Issuer, whereupon the Issuer shall (subject as provided in these Conditions) procure the delivery to, or as directed by, the relevant Bondholder of Shares credited as paid-up in full, as provided in this Condition 6.9 (*Procedure for exercise of Conversion Rights*).

If such delivery is made after 1:00 p.m. Brussels time or on a day which is not a Qualifying Business Day, such delivery shall be deemed for all purposes of these Conditions to have been made on the next following Qualifying Business Day.

The conversion date in respect of a Bond (the "**Conversion Date**") shall be the Qualifying Business Day on which delivery (or deemed delivery) of the relevant Conversion Notice (and, where applicable, the relevant Bond Certificate) is made (or deemed to be made) as provided in this Condition 6.9 (*Procedure for exercise of Conversion Rights*). The Conversion Date shall be deemed to be the date on which the Conversion Right is exercised in respect of such Bond.

A Conversion Notice, once delivered, shall be irrevocable.

Among other things, each Conversion Notice shall specify whether the relevant Bondholder elects for the Shares to be issued or transferred and delivered on exercise of Conversion Rights (including any Additional Shares) to be either US Shares, Belgian Shares or a combination thereof.

Shares to be issued or transferred and delivered on exercise of Conversion Rights (including any Additional Shares) will be issued or transferred and delivered in dematerialised or uncertificated form, as the case may be, through the securities trading system operated by (in the case of Belgian Shares) Euroclear Belgium or (in the case of US Shares) DTC, (as the case may be). Where Shares are to be issued or transferred and delivered through Euroclear Belgium or DTC, they will be delivered to the account specified by the relevant Bondholder in the relevant Payment Details as soon as practicable and in any event by not later than (in the case of Belgian Shares) the second Brussels business day or (in the case of US Shares) the second New York business day, in each case following the relevant Conversion Date (or, in the case of any Additional Shares, not later than the second Brussels or New York business day (as applicable) following the relevant Reference Date). The applicable latest required date for delivery of the Shares or Additional Shares to the relevant Bondholder(s) in respect of any exercise of Conversion Rights, as provided above, shall be the "**Scheduled Delivery Date**" in respect of such Shares or Additional Shares, as the case may be. Shares to be issued or transferred and delivered on exercise of Conversion Rights (including any Additional Shares) shall be delivered to the relevant Bondholder(s) in freely tradeable form under applicable securities laws and will not bear legends noting restrictions as to resale of such securities under US federal or state securities laws nor be subject to stop transfer instructions.

The person or persons specified for such purpose in the Payment Details will become the holder of record of the number of Shares issuable upon conversion with effect from the Registration Date (or, in the case of Additional Shares, the Additional Registration Date). The Issuer shall take all reasonable endeavours to procure such registration of the Shares to be issued as aforesaid as soon

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as practicable and in any event no later than the Scheduled Delivery Date in respect of such Shares or Additional Shares.

The Issuer shall pay all capital, stamp, issue and registration and transfer taxes and duties payable in Belgium, the United States or in any other jurisdiction in which the Issuer may be domiciled or resident or to whose taxing jurisdiction it may be generally subject ("**Specified Taxes**"), in respect of the allotment and issue or transfer and delivery of any Shares to the relevant Bondholder in respect of such exercise of Conversion Rights (including any Additional Shares) or in respect of any allotment and issue or transfer of Bonds. If the Issuer fails to pay any Specified Taxes, the relevant Bondholder shall be entitled to tender and pay the same and the Issuer, as a separate and independent stipulation, covenants to reimburse and indemnify each Bondholder in respect of any payment thereof and any interest and penalties payable and costs incurred in respect thereof.

A Bondholder exercising Conversion Rights must pay directly to the relevant authorities any capital, stamp, issue, registration and transfer taxes and duties arising on the exercise of Conversion Rights (other than any Specified Taxes which shall be payable by the Issuer). A Bondholder must also pay, or procure the payment of all, if any, taxes imposed on it and arising by reference to any disposal or deemed disposal by it of a Bond or interest therein in connection with the exercise of Conversion Rights by it. Any such capital, stamp, issue, registration or transfer taxes or duties or other taxes payable by a Bondholder are referred to as "**Bondholder Taxes**".

For the avoidance of doubt, the Calculation Agent shall not be responsible for determining whether any Specified Taxes or Bondholder Taxes are payable or the amount thereof and shall not be responsible or liable for any failure by the Issuer to pay such Specified Taxes or by a Bondholder to pay such Bondholder Taxes.

Notwithstanding any other provisions of these Conditions, a Bondholder exercising Conversion Rights following a Change of Control Conversion Right Amendment as described in Condition 11(b)(vii) (*Undertakings*) will be deemed, for the purposes of these Conditions, to have received the Shares to be issued upon conversion of the Bonds for the consideration that it would have received therefor if it had exercised its Conversion Right in respect of such Bonds at the time of the occurrence of the relevant Change of Control.

**6.10** **Cash Alternative Election**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Upon exercise of a Conversion Right, and solely in the event and to the extent that the issue and delivery of Shares in respect of such exercise of a Conversion Right would cause the issue, conversion or delivery of (i) more Shares than permitted by applicable law pursuant to Condition 12 (*Regulatory Share Cap*) or (ii) Shares in breach of applicable regulations to deliver freely transferable Shares, the Issuer may make an election (a "**Cash Alternative Election**") by giving notice (a "**Cash Alternative Election Notice**") to the relevant Bondholder by not later than the date (the "**Cash Alternative Election Date**") falling one dealing day after the relevant Conversion Date (with a copy to the Calculation Agent) to satisfy the exercise of the Conversion Right in respect of the relevant Bonds by (i) making payment, or procuring that payment is made, to the relevant Bondholder of the Cash Alternative Amount in respect of the Cash Settled Shares in respect of such exercise as specified in the relevant Cash Alternative Election Notice, and (ii) where the Cash Settled Shares are less than the Reference Shares in respect of the relevant exercise of Conversion Rights, by issuing or transferring and delivering the Physically Settled Shares, together in any such case with any other amount payable to such Bondholder pursuant to these Conditions in respect of or relating to the relevant exercise of Conversion Rights.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) The Cash Alternative Election Notice shall be irrevocable and shall specify:

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the Conversion Price in effect on the relevant Conversion Date and the number of Reference Shares in respect of such exercise of Conversion Rights;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the number of Cash Settled Shares in respect of the relevant exercise of Conversion Rights, by reference to which the Cash Alternative Amount is to be calculated; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) if the number of Cash Settled Shares (determined as aforesaid) is less than the number of Reference Shares in respect of the relevant exercise of Conversion Rights, the number of Physically Settled Shares to be transferred and delivered by the Issuer to the relevant Bondholder in respect of such exercise.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) The Issuer will pay the Cash Alternative Amount not later than the second Brussels business day following the first Brussels business day on which the Cash Alternative Amount is capable of being determined in accordance with these Conditions, by transfer to a bank account in accordance with the Payment Details.

**6.11** **Ranking and Entitlement**

Shares (including any Additional Shares) issued or transferred and delivered on exercise of Conversion Rights will from the date (such date, the "**Registration Date**" or, in the case of Additional Shares, the "**Additional Registration Date**") on which such Shares are registered in a local shareholders' register maintained or kept on behalf of the Issuer, rank *pari passu* with the fully paid Shares in issue on such Registration Date (or, as the case may be, Additional Registration Date), and the person or persons specified for such purpose in the Payment Details by the relevant Bondholder shall be treated as the holder or holders thereof with effect from, and be entitled to all rights, distribution, payments and entitlements (relating to such Shares) the record date or other due date for the establishment of entitlement for which falls on or after, such Registration Date (or, as the case may be, Additional Registration Date), except in any such case for any right excluded by mandatory provisions of applicable law or as otherwise may be provided in these Conditions.

Such Shares or, as the case may be, Additional Shares will not rank for (or, as the case may be, the relevant holder shall not be entitled to receive) any rights, distributions or payments the record date or other due date for the establishment of entitlement for which falls prior to such Registration Date (or, as the case may be, Additional Registration Date).

**6.12** **Interest on Conversion**

No payment or adjustment shall be made on exercise of Conversion Rights for any interest which otherwise would have accrued on the relevant Bonds (or, where Conversion Rights are exercised in respect of any Upcoming Amortised Payment Amount, such Upcoming Amortised Payment Amount) since the last Interest Payment Date preceding the Conversion Date relating to such Bonds (or, if such Conversion Date falls before the first Interest Payment Date, since the Issue Date).

**6.13** **Purchase or Redemption of Shares**

The Issuer or any Subsidiary of the Issuer may exercise such rights as they may from time to time enjoy to purchase or redeem or buy back any shares of the Issuer (including Shares) or any depositary or other receipts or certificates representing the same without the consent of the Bondholders.

**6.14** **No Duty to Monitor**

The Calculation Agent shall not be under any duty to monitor whether any event or circumstance has happened or exists or may happen or exist and which requires or may require an adjustment to

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be made to the Conversion Price or be responsible or liable to any person for any loss arising from any failure by any of them to do so. The Calculation Agent shall also not be responsible or liable to any person (other than in the case of the Calculation Agent, to the Issuer strictly in accordance with the relevant provisions of the Calculation Agency Agreement) for any determination as to whether or not an adjustment to the Conversion Price is required or should be made or for any determination or calculation of any such adjustment.

**6.15** **Consolidated, Amalgamation, Merger, Demerger and Re-domiciliation**

Without prejudice to the restrictions provided in Condition 2.3(c), in the case of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) any consolidation, amalgamation or merger of the Issuer with any other corporation (other than a consolidation, amalgamation or merger in which the Issuer is the continuing corporation); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) a demerger where all or substantially all the assets of the Issuer are transferred to one or more other entities; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) a re-domiciliation where the Issuer is converted to another corporation form in another country than is domicile,

where such entity or entities issue equity shares to Shareholders and *provided, in each case, that* such equity shares benefit from a listing on a stock exchange or multilateral trading facility based in a full member country of the European Union or in the United Kingdom (failing which, the Bondholders shall have such rights as if such failure constituted a Change of Control Conversion Right Amendment), the Issuer will forthwith give notice thereof to the Bondholders in accordance with Condition 16 (*Notices*) of such event and take such steps as shall be required (including the execution of an amendment or supplement to these Conditions) to ensure that each Bond then outstanding will (during the Conversion Period) be convertible into the class and amount of such shares and other Securities receivable upon such consolidation, amalgamation, merger, demerger or re-domiciliation by a holder of the number of Shares which would have become liable to be issued or transferred and delivered upon exercise of Conversion Rights immediately prior to such consolidation, amalgamation, merger, demerger or re-domiciliation.

The above provisions of this Condition 6.15 will apply, *mutatis mutandis*, to any subsequent consolidations, amalgamations, mergers, demergers or re-domiciliations.

**7.** **Redemption of Bonds**

**7.1** **Mandatory Redemption by Amortisation**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)**Scheduled Amortisation Payments**

Subject to Condition 7.1(c) (*Deferral and Advancement of Amortisation Payments*) below, on each three-month anniversary date of the Concurrent Equity Raise Pricing Date (being 18 February, 18 May, 18 August, and 18 November of each year) (each such date, a "**Scheduled Amortisation Payment Date**", with the first Scheduled Amortisation Payment Date falling on 18 February 2026 and the final Scheduled Amortisation Payment Date falling on the Original Final Maturity Date, and each such date as may become subject to deferral or advancement as provided in Condition 7.1(c) (*Deferral and Advancement of Amortisation Payments*), an "**Amortisation Payment Date**"), each Bond outstanding (except for any Bond in respect of which Conversion Rights have been exercised prior to the relevant Amortisation Payment Date) will be redeemed in instalments of €8,500 per Bond (or, in the case of the instalment scheduled to be redeemed on the Original Final

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Maturity Date, €6,500) (each an "**Amortised Payment Amount**"), together with any interest accrued and unpaid thereon as provided in Condition 5.

Upon each redemption or conversion of an Amortised Payment Amount (including, for the avoidance of doubt, any Advanced Amortised Payment Amount) on an Amortisation Payment Date (including, for the avoidance of doubt, any Advanced Amortisation Payment Date), the principal amount of each Bond shall be reduced accordingly on such Amortisation Payment Date.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)**Principal Share Settlement Option Notice**

In respect of the Amortised Payment Amount (including, for the avoidance of doubt, the Advanced Amortised Payment Amount) due on each Amortisation Payment Date (including, for the avoidance of doubt, any Advanced Amortisation Payment Date), such amount shall be paid in cash at the Cash Amortisation Price in respect of such Amortised Payment Amount unless, subject to Condition 9.9(d) (*Annulment of Share Settlement Option*), the Issuer elects (in its sole discretion) to exercise the Share Settlement Option pursuant to and in accordance with Condition 9.9 in respect of all but not some only of the Bonds by giving notice thereof (a "**Principal Share Settlement Option Notice**") (which notice shall be irrevocable) to Bondholders in accordance with Condition 16 (*Notices*) by no later than 5:00 p.m. New York time on the second Qualifying Business Day prior to such Amortisation Payment Date (or, in the case of any Advanced Amortised Payment Amount due on an Advanced Amortisation Payment Date, by no later than 5:00 p.m. New York time on the second Qualifying Business Day prior to such Advanced Amortisation Payment Date). Shares to be issued or transferred and delivered on exercise of the Share Settlement Option shall be delivered to the relevant Bondholder(s) in freely tradeable form under applicable securities laws and will not bear legends noting restrictions as to resale of such securities under US federal or state securities laws nor be subject to stop transfer instructions.

For the avoidance of doubt, in the event that the Issuer does not deliver a Principal Share Settlement Option Notice on or prior to the dates specified in the preceding paragraph in respect of all Amortised Payment Amount(s) (including, for the avoidance of doubt, any Advanced Amortised Payment Amount) due on the relevant Amortisation Payment Date (including, for the avoidance of doubt, any Advanced Amortisation Payment Date) and in accordance with Condition 16 (*Notices*), each Bondholder may, in its sole discretion, and at any time up to (and including) the Qualifying Business Day immediately preceding the relevant Amortisation Payment Date (including, for the avoidance of doubt, any Advanced Amortisation Payment Date), exercise its Bond Conversion Rights in respect of the whole of a Bond or its Amortisation Conversion Rights in respect of any Upcoming Amortised Payment Amount(s). Any such exercise of Conversion Rights, and the subsequent issue or transfer and delivery of Shares by the Issuer, shall be subject to and completed in accordance with Condition 6 (*Conversion of Bonds*).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)**Deferral and Advancement of Amortisation Payments**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) Subject to paragraph (iii) below, the Majority Bondholders may, on one or more occasions, by giving notice thereof to the Issuer (in or substantially in the form set out in Schedule 7 (*Form of Amortised Payment Advancement Notice and Deferral Notice*) of the Bond Instrument) in accordance with Condition 16 (*Notices*) at least one Brussels business day prior to a Scheduled Amortisation Payment Date, exercise their right to defer any one or more Amortised Payment Amounts (other

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than any Advanced Amortised Payment Amount) that would be payable on such Scheduled Amortisation Payment Date in respect of all or some only of the Bonds outstanding at such time so that such amounts shall not be payable on such Scheduled Amortisation Payment Date and instead shall become payable on any subsequent Scheduled Amortisation Payment Date as specified in such notice (an "**Amortised Payment Deferral**", and any such Amortised Payment Amount so deferred being a "**Deferred Amortised Payment Amount**") (subject always to the rights of the Majority Bondholders under paragraph (ii) below, to subsequently make an Amortised Payment Advancement in respect of such Deferred Amortised Payment Amount), *provided that* in relation to any Amortised Payment Deferral:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) for the purposes of the calculation of the relevant number of Deliverable Shares (if any) which shall be issued or transferred and delivered to the Bondholders in respect of a Share Settlement in accordance with Condition 5.1(b) (*Interest Share Settlement Option Notice*) and/or 7.1(b) (*Principal Share Settlement Option Notice*), if there shall have occurred an event or circumstance requiring an adjustment to the Conversion Price in accordance with Condition 6 (other than Condition 6.4 (*Conversion Price Reset*)) after the relevant SSO Reference Date and if (if the Calculation Agent determines that it is able to make such determination in its capacity as Calculation Agent) the Calculation Agent or (in any other case) an Independent Adviser determines that an adjustment is required to be made to the Relevant Share Settlement Price to give the intended result pursuant to Condition 9.9 (*Share Settlement Option*), such adjustment shall be made as determined by the Calculation Agent or, as the case may be, such Independent Adviser; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) for the avoidance of doubt, interest on any such Deferred Amortised Payment Amount shall accrue to (but excluding) the relevant Scheduled Amortised Payment Date (and be payable on each Interest Payment Date) in accordance with Condition 5.1(a) (*Interest Rate*).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) The Majority Bondholders may, at any time during each Regular Amortisation Period, by giving notice to the Issuer in accordance with Condition 16 (*Notices*) (each such notice being in or substantially in the form set out in Schedule 7 (*Form of Amortised Payment Advancement Notice and Deferral Notice*) of the Bond Instrument, an "**Amortised Payment Advancement Notice** "), exercise their right to bring forward (at the Majority Bondholders' discretion) up to two payments of the Amortised Payment Amount (or, if more than one Amortised Payment Amount is due on any Advanceable Amortisation Date in respect of such Amortised Payment Advancement Notice, up to two such Amortised Payment Amounts (at the Majority Bondholders' discretion)) in respect of all or some only of the Bonds outstanding at such time as would otherwise be scheduled (as at the date on which the Amortised Payment Advancement Notice is given (or deemed to be given pursuant to sub-paragraph (B) below)) to be paid in respect of such Bond(s) (for the avoidance of doubt, which Amortised Payment Amount may include any Amortised Payment Amount which has been subject to an Amortised Payment Deferral) either (x) on the Final Maturity Date or (y) on each of the Final Maturity Date and the immediately preceding Amortisation Payment Date (each, an "**Advanceable Amortisation Date**" in respect of such Amortised Payment Advancement Notice) (with the first such Amortised Payment Advancement (if any) in respect of any Bond being therefore in respect of the Amortised Payment

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Amount(s) which would otherwise be due either on the Original Final Maturity Date or on each of the Original Final Maturity Date and the Scheduled Amortisation Payment Date immediately preceding the Original Final Maturity Date) (any such Amortised Payment Amount so brought forward, an "**Advanced Amortised Payment Amount**") in which case such payments shall become payable on the date specified in such notice (the Amortisation Payment Date in respect of such Advanced Amortised Payment Amount(s), an "**Advanced Amortisation Payment Date**", which shall not be earlier than the third Brussels business day following the date on which the relevant Amortised Payment Advancement Notice is given (or deemed to be given pursuant to sub-paragraph (B) below)) (an "**Amortised Payment Advancement**"), and *further provided that* in relation to any Amortised Payment Advancement:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) for the purposes of the calculation of the relevant number of Deliverable Shares (if any) which shall be issued or transferred and delivered to the Bondholders following any exercise of the Share Settlement Option in accordance with Condition 5.1(b) (*Interest Share Settlement Option Notice*) and/or 7.1(b) (*Principal Share Settlement Option Notice*), if there shall have occurred an event or circumstance requiring an adjustment to the Conversion Price in accordance with Condition 6 (other than Condition 6.4 (*Conversion Price Reset*) after the relevant SSO Reference Date and if (if the Calculation Agent determines that it is able to make such determination in its capacity as Calculation Agent) the Calculation Agent or (in any other case) an Independent Adviser determines that an adjustment is required to be made to the Relevant Share Settlement Price to give the intended result pursuant to Condition 9.9 (*Share Settlement Option*), such adjustment shall be made as determined by the Calculation Agent or, as the case may be, such Independent Adviser;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) if the delivery of the relevant Amortised Payment Advancement Notice is made after 1:00 p.m. Brussels time or on a day which is not a Qualifying Business Day, such Amortised Payment Advancement Notice shall be deemed for all purposes of these Conditions to have been given on the next following Qualifying Business Day (and, for the avoidance of doubt, the relevant Advanced Amortised Payment Date shall not be earlier than the second Brussels business day following the date on which such Amortised Payment Advancement Notice is deemed to have been given);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(C) in respect of each Regular Amortisation Period, the option to require an Amortised Payment Advancement may be exercised (I) if each Amortised Payment Advancement Notice given (or deemed to be given pursuant to sub-paragraph (B) above) during such Regular Amortisation Period is in relation to Amortised Payment Amount(s) otherwise scheduled to be paid on only one Advanceable Amortisation Date, then no more than twice during such Regular Amortisation Period, or (II) if the relevant Amortised Payment Advancement Notice given (or deemed to be given pursuant to sub-paragraph (B) above) during such Regular Amortisation Period is in relation to Amortised Payment Amount(s) otherwise scheduled to be paid on two Advanceable Amortisation Dates, then only once during such Regular Amortisation Period;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(D) any Amortised Payment Advancement in respect of any Amortised Payment Amount that has previously been subject to an Amortised Payment Deferral shall not be counted for the purposes of the limitations set out in paragraph (C) above;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(E) amongst other things, each Amortised Payment Advancement Notice shall specify whether the Majority Bondholders elect for the Shares to be issued or transferred and delivered upon exercise (if any) of the Share Settlement Option in respect of the relevant Advanced Amortised Payment Amount and/or interest accrued and unpaid thereon to be either US Shares, Belgian Shares or a combination thereof; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(F) for the avoidance of doubt, interest accrued and unpaid on any such Advanced Amortised Payment Amount shall be the interest accrued and unpaid thereon to (but excluding) the relevant Advanced Amortisation Payment Date and, for the avoidance of doubt, any such interest amount shall be payable on such Advanced Amortisation Payment Date.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) Nothing in this Condition 7.1(c) shall affect the rights of the Bondholders to exercise Conversion Rights in respect of any Bonds.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)**No Other Early Redemption**

Unless previously redeemed or converted as herein provided, the Bonds will be redeemed at their remaining principal amount on the Final Maturity Date. The Bonds may only be redeemed earlier than as contemplated in this Condition 7.1 if at the option of the Bondholders in accordance with Condition 7.2 (*Redemption at the Option of Bondholders (Relevant Event*)).

**7.2** **Redemption at the Option of Bondholders (Relevant Event)**

Following the occurrence of a Relevant Event, each Bondholder will have the right to require the Issuer to redeem, in cash (but without prejudice to the rights of Bondholders to require the Issuer to issue or transfer and deliver Shares as provided below), such Bond on the Relevant Event Put Date at the relevant Early Redemption Amount. To exercise such right, the holder of the relevant Bond must give notice thereof to the Issuer in accordance with Condition 16 (*Notices*) and deliver the relevant Bond Certificate to the Issuer at any time during the Relevant Event Period.

The "**Relevant Event Put Date**" shall be the second Brussels business day after the expiry of the Relevant Event Period.

Subject to the final paragraph below, payment in respect of any such Bond shall be made in accordance with Condition 8 (*Taxation*).

Any notice given by a Bondholder to exercise its put right pursuant to this Condition 7.2, once delivered, shall be irrevocable and the Issuer shall redeem all Bonds the subject of such notices delivered as aforesaid on the Relevant Event Put Date.

Any such notice may, in the sole discretion of the relevant Bondholder, specify that such Bondholder elects to receive Belgian Shares, US Shares or a combination thereof in lieu of being paid in cash the relevant Early Redemption Amount, in which case the Issuer shall issue or transfer and deliver Shares as if the Share Settlement Option had been exercised in respect of such amounts

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due and on the basis that Condition 9.9 (*Share Settlement*) applied, *mutatis mutandis*, assuming for this purpose that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the SSO Reference Date is the relevant Put SSO Reference Date,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the Amortised Payment Amount in respect of which the Share Settlement Option is exercised is such Early Redemption Amount,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) the interest amount (if any) in respect of which the Share Settlement Option is exercised is the accrued and unpaid interest (if any) up to (but excluding) the Relevant Event Put Date,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) the Scheduled SSO Delivery Date is (in the case of Belgian Shares) the second Brussels business day or (in the case of US Shares) the second New York business day, in each case following the first Brussels business day on which such Early Redemption Amount is capable of being determined in accordance with these Conditions;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) paragraphs (iii), (iv), (v) and (vi) of the definition of Share Settlement Liquidity Event shall not apply.

This Condition 7.2 will only become effective if and when the Change of Control Resolutions are approved and filed with the clerk's office of the competent Enterprise Court in accordance with the provisions of the Belgian Companies and Associations Code.

**7.3** **Redemption if the Change of Control Resolutions are not passed**

If the Change of Control Resolutions are not, on or before the Longstop Date (a) adopted at a general meeting of the Shareholders of the Issuer, and (b) filed with the clerk's office at the competent Enterprise Court in accordance with the provisions of the Belgian Companies and Associations Code, each Bondholder will have the right to require the Issuer to redeem in cash (but without prejudice to the rights of Bondholders to require the Issuer to issue or transfer and deliver Shares as provided below) each Bond, on the date falling 30 days after the Longstop Date at the Early Redemption Amount. The Issuer shall notify each Bondholder in accordance with Condition 16 (*Notices*) promptly upon becoming aware that it has not satisfied the requirements set out in (a) or (b) above.

Each Bondholder may, in its sole discretion, notify the Issuer in writing that such Bondholder elects to receive Belgian Shares, US Shares or a combination thereof in lieu of being paid in cash the relevant Early Redemption Amount, in which case the Issuer shall issue or transfer and deliver Shares as if the Share Settlement Option had been exercised in respect of such amounts due and on the basis that Condition 9.9 (*Share Settlement*) applied, *mutatis mutandis*, assuming for this purpose that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the SSO Reference Date is the relevant Put SSO Reference Date,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the Amortised Payment Amount in respect of which the Share Settlement Option is exercised is such Early Redemption Amount,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) the interest amount (if any) in respect of which the Share Settlement Option is exercised is the accrued and unpaid interest (if any) up to (but excluding) the Relevant Event Put Date,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) the Scheduled SSO Delivery Date is (in the case of Belgian Shares) the second Brussels business day or (in the case of US Shares) the second New York business day, in each case following the first Brussels business day on which such Early Redemption Amount is capable of being determined in accordance with these Conditions;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) paragraphs (iii), (iv), (v) and (vi) of the definition of Share Settlement Liquidity Event shall not apply.

**7.4** **No Other Redemption**

The Issuer shall not be entitled to redeem or purchase the Bonds otherwise than as provided in this Condition 7 (*Redemption of Bonds*).

**7.5** **Cancellation**

All Bonds which are redeemed or in respect of which Bond Conversion Rights are exercised will be cancelled and may not be reissued or re-sold.

**8.** **Taxation**

All payments in respect of the Bonds (including, for the avoidance of doubt, any Cash Alternative Amount as well as the attribution of interest in connection with the Share Settlement Option) will be made free and clear of, and be made without deduction or withholding for, or on account of any present or future taxes, duties, assessments or governmental charges of whatever nature imposed, levied, collected, withheld or assessed by, or on behalf of, any tax jurisdiction applicable to the Issuer (including Belgium) or any political subdivision or any authority thereof or therein having power to tax (or any other jurisdiction in which the Issuer may be domiciled or resident or to whose taxing jurisdiction it may be generally subject) (each a "**Tax Jurisdiction**"), unless deduction or withholding of such taxes, duties, assessments or governmental charges is required to be made by law (a "**Tax Withholding**"). In that event, the Issuer will pay such additional amounts as will result in the receipt by the Bondholders of such amounts as would have been received by them if no such Tax Withholding been required, except that no such additional amount shall be payable in relation to any payment in respect of any Bond:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) to a Bondholder (or to a third party on behalf of a Bondholder) who is liable to such taxes, duties, assessments or governmental charges in respect of such Bond by reason of that Bondholder having some connection with a Tax Jurisdiction otherwise than merely by holding the Bond or by the receipt of amounts in respect of the Bond; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) where the Bondholder would have been able lawfully to avoid (but has not so avoided) such withholding or deduction by complying with any statutory requirement or by making a declaration of non-residence or any other claim for exemption to any tax authority, in each case following a reasonable request by the Issuer, or by providing the Issuer with a duly completed and signed Tax Status Certificate as provided in Schedule 9 of the Bond Instrument (*Form of Tax Status Certificate*), in each case following a written request by the Issuer at least 15 days before each Interest Payment Date.

Notwithstanding any other provision of these Conditions, any amounts to be paid on the Bonds by or on behalf of the Issuer will be paid net of any deduction or withholding imposed or required pursuant to an agreement described in Section 1471(b) of the U.S. Internal Revenue Code of 1986, as amended (the "Code"), or otherwise imposed pursuant to sections 1471 through 1474 of the Code (or any regulations thereunder or official interpretations thereof) or an intergovernmental agreement between the United States and another jurisdiction facilitating the implementation thereof (or any fiscal or regulatory legislation, rules or practices implementing such an intergovernmental agreement) (any such withholding or deduction, a "**FATCA Withholding**"). Neither the Issuer nor any other person will be required to pay any additional amounts or otherwise indemnify a Bondholder in respect of FATCA Withholding.

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References in these Conditions to principal and/or interest and/or any other amounts payable in respect of the Bonds shall be deemed also to refer to any additional amounts which may be payable under this Condition.

**9.** **Payments**

**9.1** **Principal and Interest**

Payment of principal and interest in respect of the Bonds pursuant to these Conditions (and delivery in lieu thereof of any Shares pursuant to any exercise of the Share Settlement Option, as applicable) will be made to, or to the order of, and in accordance with the Payment Details provided by, the persons shown in the Register (as defined in the Bond Instrument) at the close of business on the Record Date.

**9.2** **Other Amounts**

Payments of all amounts other than as provided in Condition 9.1 (*Principal and interest*) will be made as provided in these Conditions.

**9.3** **Record Date**

For the purposes of these Conditions, "**Record Date**" means the Brussels business day before the due date for the relevant payment of principal or interest (disregarding for this purpose any exercise of the Share Settlement Option or Conversion Rights in respect thereof).

**9.4** **Payments**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Each cash payment in respect of Bonds pursuant to Conditions 9.1 (*Principal and interest*) and 9.2 (*Other amounts*) will, with respect to each relevant Bondholder, be made by transfer to a bank account in accordance with the relevant Payment Details.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) The Issuer shall initiate, or shall procure the initiation of, cash payment instructions for value as of the due date, or, if the due date is not a Brussels business day, for value the next succeeding Brussels business day.

**9.5** **Delay in Payment**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Bondholders will not be entitled to any interest or other payment for any delay after the due date in receiving the cash amount due to be paid or, as the case may be, the Shares due to be delivered:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) as a result of the due date not being a business day in Brussels or in the city in which the recipient account is based; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) as a result of the relevant Bondholder failing to provide fulsome and correct Payment Details.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) If any date for payment in respect of any Bond is not a Brussels business day, each Bondholder shall not be entitled to payment until the next following Brussels business day.

**9.6** **Calculation Agent**

The Issuer reserves the right, subject to the prior approval of the Majority Bondholders after being given not less than 20 London business days' notice under the Calculation Agency Agreement at any time to vary or terminate the appointment of the Calculation Agent and appoint another Calculation Agent, provided that they will maintain a Calculation Agent which shall be a financial

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institution of international repute or an independent financial adviser with appropriate expertise. The Issuer shall promptly notify the Bondholders of any such proposal of a variation, termination or appointment.

**9.7** **No Charges**

Neither the Issuer nor any person or agent acting on its behalf shall make or impose on a Bondholder any charge or commission in relation to any payment, transfer or conversion in respect of the Bonds including any issue or delivery of Shares pursuant to the exercise of any Share Settlement Option.

**9.8** **Fractions**

When making payments to Bondholders, if the relevant payment is not of an amount which is a whole multiple of the smallest unit of the relevant currency in which such payment is to be made, such payment will be rounded down to the nearest unit.

**9.9** **Share Settlement Option**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)**Exercise of Share Settlement Option**

If:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) an Interest Share Settlement Option Notice is given by the Issuer in accordance with Condition 5.1(b) (*Interest Share Settlement Option Notice*); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) a Principal Share Settlement Option Notice is given by the Issuer in accordance with Condition 7.1(b) (*Principal Share Settlement Option Notice*),

as applicable, the Issuer's obligation to pay cash interest on each Bond on the relevant Interest Payment Date pursuant to Condition 5.1(a) (*Interest Rate*) or on any Advanced Amortisation Payment Date or to redeem in cash a principal amount of the Bonds in an Amortised Payment Amount on the relevant Amortisation Payment Date (including, for the avoidance of doubt, any Advanced Amortisation Payment Date) pursuant to Condition 7.1(a) (*Scheduled Amortisation Payments*) shall, subject to Condition 9.9(d) (*Annulment of Share Settlement Option*), be satisfied by the issue or transfer and delivery (and, without prejudice to any of the provisions of these Conditions, which Shares shall be paid up in full by contribution in kind by the relevant Bondholder of its receivable on the Issuer for payment of the relevant amounts due under the Bonds) against issuance to the relevant Bondholder of the relevant number of Deliverable Shares (the "**Share Settlement Option**" in respect of the relevant Interest Payment Date or Amortisation Payment Date, as applicable) with respect to all but not some only of the Bonds as soon as practicable and in any event not later than the applicable Scheduled SSO Delivery Date.

Notwithstanding the Issuer's option (in its sole discretion) to exercise any Share Settlement Option pursuant to and in accordance with these Conditions, the Issuer shall be deemed to be required to exercise a Share Settlement Option in respect of any payment of interest or principal amounts under the Bonds where the Issuer is in possession of Restricted Information in relation to the Shares at the time of such payment, except if the Issuer is restricted by applicable laws or regulations from issuing or transferring and delivering Shares in accordance with these Conditions in which case it shall make any such payment in cash.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)**Share Settlement**

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Where the Share Settlement Option has been validly exercised, subject to Condition 9.9(d) (*Annulment of Share Settlement Option*) and without prejudice to Condition 8 (*Taxation*) which shall apply to Condition 9.9(b)(i) and Condition 9.9(b)(ii) below:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) in lieu of the payment in cash by the Issuer in respect of interest on the relevant Interest Payment Date (other than in respect of an Advanced Amortised Payment Amount) or, as the case may be, in respect of any Amortised Payment Amount (other than an Advanced Amortised Payment Amount) on the relevant Scheduled Amortisation Payment Date, as applicable, the Issuer shall organise an increase of its capital and the Bondholders shall subscribe to such capital increase by way of contribution in kind by the Bondholders of their receivable on the Issuer for such payment of the accrued interest and/or Amortised Payment Amount against issuance of the Deliverable Shares to the Bondholders as soon as practicable and in any event not later than such Interest Payment Date or Scheduled Amortisation Payment Date, as the case may be.

For the avoidance of doubt, any Deliverable Shares issued in accordance with this Condition 9.9(b)(i) shall be fully paid-up; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) in lieu of the payment in cash in respect of interest or, as the case may be, in respect of an Advanced Amortised Payment Amount, in each case on an Advanced Amortisation Payment Date, the Issuer shall organise an increase of its capital and the Bondholders shall subscribe to such capital increase by way of contribution in kind by the Bondholders of their receivable on the Issuer for such payment of the accrued interest and/or Advanced Amortised Payment Amount against issuance of the Deliverable Shares to the Bondholders as soon as practicable and in any event not later than:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) such Advanced Amortisation Payment Date; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) (if any of the Deliverable Shares are US Shares, and in any such case in the case of such US Shares only) if later, the date falling three New York business days following the date (or, as applicable pursuant to these Conditions, deemed date) of delivery of the Amortised Payment Advancement Notice.

For the avoidance of doubt, any Deliverable Shares issued in accordance with this Condition 9.9(b)(ii) shall be fully paid-up;

(each of (i) and/or (ii), a "**Share Settlement**"). The applicable latest required date for delivery of the Deliverable Shares to Bondholders, as provided above, shall be the "**Scheduled SSO Delivery Date**" in respect thereof, *provided that*, (A) where proviso (i) or (ii) to the definition of "Reference Lowest Daily Market Price" applies to the Reference Lowest Daily Market Price required for the determination of the number of Deliverable Shares, the Scheduled SSO Delivery Date in respect thereof shall be the later of (1) the date determined as aforesaid and (2) the first date on which the adjusted Conversion Price referred to in proviso (i) or (ii) of such definition as aforesaid is capable of being determined in accordance with Condition 6.2 (*Adjustment of Conversion Price*), and (B) where the relevant Bondholder fails to give the Belgian/US Share Confirmation by the specified deadline as contemplated in Condition 9.9(e)(vi)(B), the Scheduled SSO Delivery Date shall be the later of (i) the date determined as provided above and (ii) (in the case of Belgian Shares) two Brussels business days or (in the case of US Shares) two New

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York business days, in each case following the date on which the Belgian/US Share Confirmation is given (or, as applicable pursuant to these Conditions, deemed to be given).

Fractions of Shares will not be issued or transferred or delivered pursuant to this Condition 9.9 and no cash payment or other adjustment will be made in lieu thereof. However, to the extent that the Shares to be issued and/or transferred and delivered pursuant to this Condition 9.9 (*Share Settlement Option*) are to be registered in the same name, the number of Shares to be issued and/or transferred and delivered in respect thereof shall be calculated on the basis of the aggregate principal amount of such Bonds, as determined by the Calculation Agent.

Promptly following the determination of the Relevant Share Settlement Price and the number of Deliverable Shares, the Issuer shall give notice thereof to the Bondholders in accordance with Condition 16 (*Notices*).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)**Certain Definitions**

For the purposes of these Conditions:

"**Deliverable Shares**" means, in respect of any Bondholder and any interest amount payable on Interest Payment Date (or, as the case may be, Advanced Amortisation Payment Date) or principal amount of the Bonds redeemable on an Amortisation Payment Date (including, for the avoidance of doubt, any Advanced Amortisation Payment Date), in each case which would otherwise be payable in cash, such number of Shares determined by the Calculation Agent by dividing the relevant interest amount in respect of such Bonds on such Interest Payment Date (or, as the case may be, Advanced Amortisation Payment Date) or the relevant Amortised Payment Amount in respect of such Bond on such Amortisation Payment Date, as applicable, by the Relevant Share Settlement Price in respect of such Interest Payment Date or Amortisation Payment Date (as applicable), subject to Condition 7.1(c)(i)(A) (*Deferral and Advancement of Amortisation Payments*) and Condition 7.1(c)(ii)(A) (*Deferral and Advancement of Amortisation Payments*).

"**Offer Period**" means any period commencing on the date of first public announcement of an offer or tender (howsoever described) by any person or persons in respect of all or a majority of the issued and outstanding Shares and ending on the date that offer or tender ceases to be open for acceptance or, if earlier, on which that offer or tender lapses or terminates or is withdrawn.

"**Reference Lowest Daily Market Price**" means, in respect of any SSO Reference Date, such price (rounded to the nearest whole multiple of €0.0001 (with €0.00005 being rounded upwards)) as is equal to (x) the lower of (i) the Volume Weighted Average Price of a Share (translated if necessary into EUR at the Prevailing Rate) on such SSO Reference Date and (ii) the lowest of the five Volume Weighted Average Prices of a Share (translated if necessary into EUR at the Prevailing Rate) on each of the five consecutive dealing days ending on (and including) such SSO Reference Date, or (y) if such SSO Reference Date is not a dealing day, such price as is determined pursuant to (x)(ii) above, in each case *provided that*:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) if any such dealing day falls on or after the Applicable Adjustment Reference Date in respect of any event giving rise to an adjustment to the Conversion Price pursuant to Condition 6.2 (*Adjustment of Conversion Price*) and the relevant SSO Registration Date falls on or before the Applicable Adjustment Record Date in respect of such event, then the Volume Weighted Average Price of a Share on such

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dealing day shall be multiplied by a fraction, (x) the numerator of which is the Conversion Price in effect immediately prior to such adjustment, and (y) the denominator of which is the Conversion Price so adjusted;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) if any such dealing day falls before the Applicable Adjustment Reference Date in respect of any event giving rise to an adjustment to the Conversion Price pursuant to Condition 6.2 (*Adjustment of Conversion Price*) and the relevant SSO Registration Date falls after the Applicable Adjustment Record Date in respect of such event, then the Volume Weighted Average Price on such dealing day shall be multiplied by a fraction, (x) the numerator of which is the Conversion Price so adjusted, and (y) the denominator of which is the Conversion Price in effect immediately prior to such adjustment;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) if such SSO Reference Date is the Issue Date, the Reference Lowest Daily Market Price in respect of such date shall be €4.00; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) if any doubt shall arise as to the appropriate calculation of the Reference Lowest Daily Market Price, or if the Reference Lowest Daily Market Price cannot be determined as provided above, the Reference Lowest Daily Market Price shall be equal to such price as is determined in such other manner as an Independent Adviser shall consider to be appropriate to give the intended result.

"**Relevant Share Settlement Price**" means in respect of any SSO Reference Date, the lower of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) the Conversion Price in effect on the relevant Scheduled Amortisation Payment Date, or as the case may be, Interest Payment Date in relation to which the Share Settlement Option is exercised (or, if such date falls on an Advanced Amortisation Payment Date, the Conversion Price in effect on the date falling two Qualifying Business Days prior to such Advanced Amortisation Payment Date); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) the product (rounded to the nearest whole multiple of €0.0001 (with €0.00005 being rounded upwards)) of (x) 90 per cent. and (y) the Reference Lowest Daily Market Price in respect of such SSO Reference Date,

as determined by the Calculation Agent.

"**SSO Reference Date**" means, in respect of any Share Settlement, the relevant Interest Payment Date or Amortisation Payment Date in respect of which the Share Settlement Option is exercised, *provided that*:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) in the case of Share Settlement of any Deferred Amortised Payment Amount, (except as provided in (ii) below) the SSO Reference Date shall be the originally Scheduled Amortisation Payment Date in respect of such deferred Amortised Payment Amount; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) in the case of Share Settlement of any Amortised Payment Amount which is subject to an Amortised Payment Advancement (including, for the avoidance of doubt, any Amortised Payment Amount which was previously subject to an Amortised Payment Deferral), the SSO Reference Date shall be whichever date determined pursuant to (A) or (B) below results in the lowest Reference Lowest Daily Market Price in respect of such date:

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) the Scheduled Amortisation Payment Date immediately preceding the date on which the relevant Amortised Payment Advancement Notice was given (or deemed to be given pursuant to Condition 7.1(c)(ii)(B) (*Deferral and Advancement of Amortisation Payments*); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) the Scheduled Amortisation Payment Date immediately preceding the date determined in accordance with (A) above (or, if there is no such Amortisation Payment Date, the SSO Reference Date shall be the Issue Date).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)**Annulment of Share Settlement Option**

If the relevant Share Settlement Option is exercised but a Share Settlement Liquidity Event occurs prior to registration of the Shares in respect of such exercise of the Share Settlement Option, then such Share Settlement shall be invalid and annulled and the relevant interest amount or Amortised Payment Amount shall be paid in cash in accordance with the relevant provisions of Condition 5.1 (*Interest Rate*) or Condition 7.1 (*Mandatory Redemption by Amortisation*), as applicable, and payment in respect thereof shall be made in accordance with Conditions 9.1 (*Principal and interest*) to 9.8 (*Fractions*). Any Amortised Payment Amounts that are subject to cash payment shall be payable at the Cash Amortisation Price in respect thereof specified in Condition 7.1(b) (*Principal Share Settlement Option Notice*).

Notwithstanding anything to the contrary in these Conditions, where any exercise of the Share Settlement Option is deemed to be invalid and annulled as aforesaid, the relevant interest payment and/or Amortised Payment Amount shall be made in cash:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) on the relevant Interest Payment Date or Scheduled Amortisation Payment Date (or, as the case may be, Advanced Amortisation Payment Date); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) if the relevant Share Settlement Liquidity Event first occurred on or after the Brussels business day falling immediately prior to the relevant Interest Payment Date or Scheduled Amortisation Payment Date (or, as the case may be, Advanced Amortisation Payment Date), on the second Brussels business day following the date on which such Share Settlement Liquidity Event occurs,

*provided that* where paragraph (ii) applies the amount of interest and/or principal payable shall be such amount(s) as would have been payable on the relevant Interest Payment Date or Scheduled Amortisation Payment Date (or, as the case may be, Advanced Amortisation Payment Date) and Bondholders will not be entitled to any interest or other payment for such delay in receiving such interest and/or principal amount(s) as a result of the relevant exercise of the Share Settlement Option being deemed to be invalid and annulled as aforesaid.

For the purposes of these Conditions:

"**Daily Traded Value**" means:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) (for the purposes of determining any Share Average DTV) on any Qualifying Stock Exchange Day, the aggregate daily traded value (if any) of the Shares on (x) the Relevant Stock Exchange in respect thereof and (y) (if the Shares are listed and admitted to trading on any of the US Markets) such US Market(s), in each case, on such Qualifying Stock Exchange Day as published on Bloomberg page HP (or any successor Bloomberg ticker or page) in respect of the Shares and such Relevant

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Stock Exchange and (if any) US Market(s) (such pages being as at the Issue Date, for the avoidance of doubt, NYXH BB Equity HP and NYXH US Equity HP respectively) (using the setting labelled "PR093 Turnover / Traded Value", or any successor setting), in each case translated if necessary into EUR at the Prevailing Rate on such Qualifying Stock Exchange Day, all as determined by the Calculation Agent as at the Bloomberg Screen Observation Time in respect of such Qualifying Stock Exchange Day, or, if the Daily Traded Value is not capable of being so determined, as determined by an Independent Adviser;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) (for the purposes of determining any Relevant Stock Exchange) on any day on which the relevant stock exchange or securities market on which the Shares, other Securities, Spin-Off Securities, options, warrants or other rights or assets are listed and admitted to trading is open for business (other than any day on which such trading is scheduled to close prior to its regular weekday closing time), the aggregate daily traded value (if any) of the Shares, other Securities, Spin-Off Securities, options, warrants or other rights or assets, as the case may be, on such stock exchange or securities market on such day as published on Bloomberg page HP (or any successor Bloomberg ticker or page) in respect of the Shares, other Securities, Spin-Off Securities, options, warrants or other rights or assets, as the case may be, and such stock exchange or securities market (using the setting labelled "PR093 Turnover / Traded Value", or any successor setting), translated if necessary into EUR at the Prevailing Rate on such day, all as determined by the Calculation Agent as at the Bloomberg Screen Observation Time in respect of such day, or, if the Daily Traded Value is not capable of being so determined, as determined by an Independent Adviser.

"**Minimum PMP**" in effect on any date means initially €1.25, subject to adjustment with effect from (and including) any Applicable Adjustment Reference Date in respect of any event giving rise to an adjustment to the Conversion Price pursuant to Condition 6.2 (*Adjustment of Conversion Price*), the Minimum PMP so adjusted being equal to the product (rounded to the nearest whole multiple of €0.0001 (with €0.00005 being rounded upwards)) of (i) the Minimum PMP in effect immediately prior to such adjustment and (ii) a fraction, (x) the numerator of which is the Conversion Price so adjusted, and (y) the denominator of which is the Conversion Price in effect immediately prior to such adjustment.

"**Prevailing Market Price**" means, on any date falling in a Share Settlement Liquidity Period, the arithmetic mean (rounded to the nearest whole multiple of €0.0001 (with €0.00005 being rounded upwards)) of the Volume Weighted Average Prices (translated if necessary into EUR at the Prevailing Rate) on each dealing day comprised in the period of five consecutive dealing days ending on (and including) the dealing day immediately preceding such date, provided that where (i) the Applicable Adjustment Reference Date in respect of any event giving rise to an adjustment to the Conversion Price pursuant to Condition 6.2 (*Adjustment of Conversion Price*) falls on or prior to the last day of such Share Settlement Liquidity Period, and (ii) any such dealing day falls prior to such Applicable Adjustment Reference Date, the Volume Weighted Average Price of a Share on such dealing day shall be multiplied by a fraction, (x) the numerator of which is the Conversion Price so adjusted, and (y) the denominator of which is the Conversion Price in effect immediately prior to such adjustment.

"**Share Average DTV**" means, in respect of any Share Settlement Liquidity Period, the arithmetic mean (rounded to the nearest whole multiple of €1.00 (with €0.50 being rounded

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upwards)) of the Daily Traded Values on each Qualifying Stock Exchange Day comprised in such Share Settlement Liquidity Period.

A "**Share Settlement Liquidity Event**" shall have occurred in respect of any exercise of the Share Settlement Option if one or more of the following conditions is met (and, other than in the case of paragraph (vii) below, is not waived by the Majority Bondholders in writing):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) on any date falling in the relevant Share Settlement Liquidity Period, the Shares are not (1) listed and admitted to trading on the Relevant Stock Exchange as at such date, or are suspended from trading on such market (provided that trading of the Shares shall not be considered to be suspended on any day on which a general suspension of trading on such market has occurred) on such date, or (2) a participating security in Euroclear Belgium or DTC (as applicable) on such date;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) an Event of Default or Potential Event of Default shall have occurred and be continuing as at any date falling in the relevant Share Settlement Liquidity Period;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) a Share Settlement Free Float Event shall have occurred on any date falling in the relevant Share Settlement Liquidity Period;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) the Share Average DTV in respect of the relevant Share Settlement Liquidity Period is less than €350,000;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) the Prevailing Market Price of a Share on any dealing day falling in the relevant Share Settlement Liquidity Period is less than the Minimum PMP in effect on the last day of such Share Settlement Liquidity Period;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) an Offer Period (as defined below) shall be continuing as at any date falling in the relevant Share Settlement Liquidity Period; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) the Issuer is notified in writing no later than the last day of the relevant Share Settlement Liquidity Period by any Bondholder in accordance with Condition 16 (*Notices*) that the exercise of the relevant Share Settlement Option would result in such Bondholder acquiring (alone or in concert) more than 9.99 per cent. of the voting rights in the share capital of the Issuer.

"**Share Settlement Liquidity Period**" means, in respect of any exercise of the Share Settlement Option:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) (for the purpose of limbs (i), (ii), (iii), (vi) and (vii) of the definition of "Share Settlement Liquidity Event") the period from (and including) the Interest Payment Date immediately preceding the relevant SSO Reference Date (or, in the case of any interest or an Advanced Amortised Payment Amount due on an Advanced Amortisation Payment Date, the Interest Payment Date immediately preceding the relevant Advanced Amortisation Payment Date) (or, if none, from (and including) the Issue Date) to (and including) the date immediately preceding the date on which the Deliverable Shares are issued or transferred and delivered to Bondholders; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) (for the purpose of limbs (iv) and (v) of the definition of "Share Settlement Liquidity Event") the period from (and including) the Interest Payment Date immediately preceding the relevant SSO Reference Date (or, in the case of any interest or an Advanced Amortised Payment Amount due on an Advanced

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Amortisation Payment Date, the Interest Payment Date immediately preceding the relevant Advanced Amortisation Payment Date) (or, if none, from (and including) the Issue Date) to (and including) the second dealing day prior to the SSO Reference Date (or, in the case of any interest or an Advanced Amortised Payment Amount due on an Advanced Amortisation Payment Date, the relevant Advanced Amortisation Payment Date).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e)**Provisions relating to the Share Settlement Option**

The following provisions shall apply in respect of an exercise of a Share Settlement Option:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) Shares issued and/or transferred and delivered (and, without prejudice to any of the provisions of these Conditions, which Shares shall be paid up in full by setting off the Issuer's debt to pay relevant amounts due under the Bonds) pursuant to this Condition 9.9 (*Share Settlement Option*) will from the date (such date (which shall apply to all Deliverable Shares (whether comprising Belgian Shares and/or US Shares)) in respect of the relevant Bondholder and interest amount and/or principal amount in respect of which the Share Settlement Option was exercised), the "**SSO Registration Date**") on which such Shares are registered in a local shareholders' register maintained or kept on behalf of the Issuer, rank *pari passu* with the fully paid Shares in issue on such SSO Registration Date and the person or persons specified for such purpose in the Payment Details by the relevant Bondholder shall be treated as the holder or holders thereof with effect from, and be entitled to all rights, distribution, payments and entitlements (relating to such Shares) in respect of which the record date or other due date for the establishment of entitlement in respect of the Shares for which falls on or after, such SSO Registration Date, except in any such case for any right excluded by mandatory provisions of applicable law or as otherwise may be provided in these Conditions. Such Deliverable Shares will not rank for (or, as the case may be, the relevant holder shall not be entitled to receive) any rights, distributions or payments the record date or other due date for the establishment of entitlement for which falls prior to such SSO Registration Date.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) The Issuer shall pay all Specified Taxes in respect of the issue or transfer and delivery of any Deliverable Shares to the relevant Bondholder. If the Issuer fails to pay any Specified Taxes assessable or payable in respect of the issue or transfer and delivery of any Deliverable Shares (including the allotment, issue and delivery of Shares represented thereby) to the relevant Bondholder, the relevant Bondholder shall be entitled to tender and pay the same and the Issuer, as a separate and independent stipulation, covenants to reimburse and indemnify each Bondholder in respect of any payment thereof and any interest and penalties payable and documented costs incurred in respect thereof.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) If the exercise of a Share Settlement Option results in a transfer tax being assessed on any Bondholder, the Issuer shall reimburse each affected Bondholder by issuing or transferring and delivering Shares (or, if the Issuer is unable or otherwise not permitted for reason to deliver such Shares, in cash) no longer than the second Brussels business day after the relevant Interest Payment Date or Amortisation Payment Date (including, for the avoidance of doubt, an Advanced Amortisation Payment Date) at the same Relevant Share Settlement Price that applied in respect of such payment of interest amount or Amortised Payment Amount.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) A Bondholder must pay any capital, stamp, issue and registration and transfer taxes or duties arising on the issue or transfer and delivery of the relevant Deliverable Shares, excluding any Specified Taxes or other taxes specified in paragraph (iii) above (which shall be payable by the Issuer). Such Bondholder must pay, or procure payment of, all, if any, taxes arising by reference to any disposal or deemed disposal of a Bond or interest therein by it in connection with the exercise of such Share Settlement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) Deliverable Shares will be deemed to be issued and/or transferred and delivered as of the relevant SSO Registration Date and the Issuer shall procure that such SSO Registration Date in respect thereof shall occur no later than the Scheduled SSO Delivery Date in respect of such Deliverable Shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) Upon delivery by the Issuer of an Interest Share Settlement Option Notice or Principal Share Settlement Option Notice, each Bondholder shall be required to confirm whether it elects for the Deliverable Shares to be issued or transferred and delivered in relation to such Share Settlement to be either US Shares or Belgian Shares or a combination thereof (the "**Belgian/US Share Confirmation**" in respect of such Share Settlement and such Bondholder), *provided that* such Belgian/US Share Confirmation shall be so given:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) (where such Principal Share Settlement Option Notice or Interest Share Settlement Option Notice is given in relation to an Advanced Amortised Payment Amount or interest accrued and unpaid thereon, as the case may be) in the relevant Amortised Payment Advancement Notice; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) (in any other case) by giving notice in writing to the Issuer in accordance with Condition 16 (*Notices*) (which may be by email), with a copy to the Calculation Agent, no later than the Qualifying Business Day prior to the Interest Payment Date or Scheduled Amortisation Payment Date, as the case may be, in relation to which such Interest Share Settlement Option Notice or Principal Share Settlement Option Notice, as the case may be, was given (provided that if delivery of the Belgian/US Share Confirmation is made after 1:00 p.m. Brussels time or on a day which is not a Qualifying Business Day, such delivery shall be deemed for all purposes of these Conditions to have been made on the next following Qualifying Business Day), failing which proviso (B) to the definition of "Scheduled SSO Delivery Date" shall apply in respect of such Share Settlement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) Deliverable Shares to be issued or transferred and delivered in relation to a Share Settlement will be issued or transferred and delivered in uncertificated form through the dematerialised securities trading system operated by Euroclear Belgium (in the case of Belgian Shares) or DTC (in the case of US Shares).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(viii) Where Deliverable Shares are to be issued or transferred and delivered through the Euroclear Belgium or DTC, they will be delivered to the account specified by the relevant Bondholder in the Payment Details.

**10.** **Events of Default**

If any of the following events (each an "**Event of Default**") occurs and is continuing, the holders of at least one-quarter in principal amount of the Bonds then outstanding may give notice in writing to the Issuer that the Bonds are, and upon such notice the Bonds shall accordingly immediately

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become, without further action or formality, due and repayable in cash at (but without prejudice to the rights of Bondholders to require the Issuer to issue or transfer and deliver Shares as provided below) the Early Redemption Amount:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) default in the payment when due of any interest or any other amounts (other than principal) with respect to the Bonds or, if such default is caused by a Disruption Event, on the second Brussels business day after the Disruption Event has been remedied;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) default in the payment when due of the principal of the Bonds (on an Amortisation Payment Date, at final maturity, upon redemption or otherwise) or, if such default is caused by a Disruption Event, on the second Brussels business day after the Disruption Event has been remedied;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) the Issuer fails to deliver Shares following any exercise of Conversion Rights or in respect of any Share Settlement Option on the date specified in these Conditions;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) the Issuer does not perform or comply with any of its respective obligations under Condition 2 (*Covenants*), Condition 11(c) (*Undertakings*) or Condition 11(k) (*Undertakings*);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) the Issuer does not perform or comply with any one or more of its other obligations in the Bonds or the Bond Documents or if any event occurs or any action is taken or failed to be taken which is (or but for the provisions of any applicable law would be) a breach of any such obligation, and which default or breach is incapable of remedy or is not remedied within five Brussels business days after the earlier of (i) the date the Issuer became aware of such default or breach or (ii) notice of such default or breach shall have been received by the Issuer from any Bondholder requiring the same to be remedied;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) any other present or future Financial Indebtedness of the Issuer or any of its Subsidiaries is not paid when due or (as the case may be) within any originally applicable grace period, or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) any such Financial Indebtedness becomes (or becomes capable of being declared) due and payable prior to its stated maturity or scheduled due date by reason of an event of default or prepayment event or put option event or the like (howsoever described), or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) the Issuer or any of its Subsidiaries fails to pay when due any amount payable by it under any present or future Financial Indebtedness Guarantee,

*provided that* the aggregate amount of the relevant Financial Indebtedness and/or Financial Indebtedness Guarantee in respect of which one or more of the events mentioned above in this Condition 10(f) (*Events of Default*) have occurred equals or exceeds €3,000,000 (or its equivalent in any other currency or currencies);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) one or more final, non-appealable judgments or orders or arbitration awards for the payment an amount in excess of €3,000,000 (or its equivalent in any other currency or currencies), whether individually or in aggregate, is rendered or granted against the Issuer or any of its Subsidiaries and continue(s) unsatisfied and unstayed for a period of 30 days after the date thereof or, if later, the date therein specified for payment;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) a distress, attachment, execution or other legal process is levied, enforced or sued out on or against the property, assets or revenues of the Issuer or any of its Subsidiaries with a value, individually or in the aggregate, in excess of €3,000,000 (or its equivalent in any other currency or currencies) and is not discharged within 30 days;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) any mortgage, charge, pledge, lien or other encumbrance, present or future, created or assumed by the Issuer or any of its Subsidiaries, over assets with a value, individually or in the aggregate, in excess of €3,000,000 (or its equivalent in any other currency or currencies), becomes enforceable and any step is taken to enforce it (including the taking of possession or the appointment of a receiver, administrative receiver, administrator, manager or other similar person) and is not discharged, stayed or stopped within 30 days;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(j) the Issuer or any of its Subsidiaries is (or is deemed by law or a court or its auditors to be) insolvent or bankrupt or no longer a going concern or unable to pay its debts as they fall due, or stops, suspends or announces its intention to stop or suspend payment of any of its debts or, by reason of actual or anticipated financial difficulties, the Issuer or any of its Subsidiaries commences negotiations with one or more of its creditors with a view to deferring, rescheduling or otherwise readjusting generally its Financial Indebtedness for or in respect of moneys borrowed or raised, or an insolvency administrator (including a *curateur* / *curator* and a *médiateur d'entreprise/ondernemingsbemiddelaar* under Book XX of the Belgian Code of Economic Law), or a liquidator of the Issuer or any of its Subsidiaries is appointed (or application for any such appointment is made) other than in the context of a solvent liquidation or a moratorium is agreed or declared or comes into effect in respect of or affecting any debt of the Issuer or any of its Subsidiaries; or any court

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(k) an administrator is appointed, an order is made or an effective resolution passed for the winding-up or dissolution or administration of the Issuer or any of its Subsidiaries (and such order is not discharged within 30 days), or the Issuer (itself, or taken together with its Subsidiaries) ceases or threatens to cease to carry on all or any substantial part of its business or operations (or disposes of any substantial part of its assets), except for the purpose of and followed by a reconstruction, amalgamation, reorganisation, merger or consolidation on terms approved by the Bondholders;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(l) any representation or statement made or deemed to be made by the Issuer in the Subscription Agreement (or other purchase or similar agreements entered into between the Issuer and any Bondholder in connection with the Bonds) is or proves to have been incorrect or misleading in any material respect when made or deemed to be made and is not remedied within five Brussels business days of the earlier of (i) the initial subscriber named therein giving notice to the Issuer, and (ii) the Issuer becoming aware of the event or circumstance giving rise to the representation or warranty being incorrect; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(m) any event occurs which under the laws of Belgium or other jurisdiction of incorporation of the Issuer or its Subsidiaries has an analogous effect to any of the events referred to in paragraphs (h) to (k) (inclusive).

Upon notice being given as provided in the first paragraph of this Condition 10 and the Bonds being due and repayable at the relevant Early Redemption Amount together with any accrued and unpaid interest to (but excluding) the date of such notice, each Bondholder may, in its sole discretion, upon giving notice to the Issuer no later than five London and Brussels business days after the giving of the notice described in the first paragraph of this Condition 10, require the Issuer to issue or transfer and deliver Shares in lieu of such amounts being paid in cash, *provided that* the Issuer shall not be required under any circumstance to issue or transfer and deliver any Shares under this paragraph to

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the extent that such issuance or transfer and delivery would cause or result in Shares being required to be issued or transferred and delivered in violation of the Issuer's Articles of Association or otherwise not permitted by applicable laws or regulations. Upon the exercise of such right by a Bondholder (and subject to the foregoing), the Issuer shall issue or transfer and deliver Shares in respect of such amounts due and on the basis that Condition 9.9 (*Share Settlement Option*) applied, *mutatis mutandis*, assuming for this purpose that the Share Settlement Reference Date is the relevant Put SSO Reference Date, the Amortised Payment Amount in respect of which the Share Settlement Option is exercised is such Early Redemption Amount, the interest amount (if any) in respect of which the Share Settlement Option is exercised is the accrued and unpaid interest (if any) up to (but excluding) the date of such notice, the Scheduled SSO Delivery Date is the first date on which the Early Redemption Amount is capable of being determined in accordance with these Conditions and that the occurrence of any Share Settlement Liquidity Event is ignored and deemed to not have occurred.

Following an Event of Default and the relevant Bondholders having given notice to the Issuer that the Bonds are due and payable, references in these Conditions and the Bond Instrument to the principal amount of the Bonds shall, unless the context otherwise requires, include the Early Redemption Amount.

An Event of Default shall be deemed to be continuing if it has not been remedied or waived.

**11.** **Undertakings**

Whilst any Conversion Right remains exercisable, the Issuer will, save with the approval of the holders of at least 90 per cent. in principal amount of the Bonds outstanding:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) not issue or pay up any Securities, in either case by way of capitalisation of profits or reserves or for no consideration, other than:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) by the issue of fully paid Shares or other Securities to Shareholders and other holders of shares of the Issuer which by their terms entitle the holders thereof to receive shares or other Securities on a capitalisation of profits or reserves; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) by the issue of fully paid Shares, issued wholly, ignoring fractional entitlements, in lieu of the whole or part of a Dividend in cash; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) by the issue of fully paid Shares to the Issuer itself for no consideration, to be further conveyed as treasury shares against consideration; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) by the issue of Shares or any equity shares or other Securities to, or for the benefit of, employees or former employees, director or executive holding or formerly holding executive office (including directors holding or formerly holding executive office or non-executive office, consultants or former consultants or the personal service company of any such person) or their spouses or relatives, in each case of the Issuer or any of its Subsidiaries or any associated company or to a trustee or nominee to be held for the benefit of any such person, in any such case pursuant to an employee, contractor, director or executive share or option or incentive scheme whether for all employees, contractors, directors or executives or any one or more of them,

((i) to (iv) above each being a "**Permitted Issue**"), unless, in any such case, the same constitutes a Dividend or otherwise falls to be taken into account for a determination as to whether an adjustment is to be made to the Conversion Price pursuant to Condition 6.2 (*Adjustment of Conversion Price*), regardless of whether in fact an adjustment falls to be

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made in respect of the relevant event (or would, but for the provisions of Condition 6.7 (*Rounding Down and Notice of Adjustment to the Conversion Price*) relating to roundings and minimum adjustments or the carry forward of adjustments, give rise to an adjustment to the Conversion Price);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) not modify the rights attaching to the Shares with respect to voting, dividends or liquidation nor issue any other class of equity shares carrying any rights which are more favourable than the rights attaching to the Shares but so that nothing in this Condition 11(b) shall prevent:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) any consolidation, reclassification, redesignation or subdivision of the Shares; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) any modification of such rights which is not, in the opinion of an Independent Adviser, materially prejudicial to the interests of the holders of the Bonds; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) any issue of equity shares where the issue of such equity shares results, or would, but for the provisions of Condition 6.7 (*Rounding Down and Notice of Adjustment to the Conversion Price*) relating to roundings and minimum adjustments or the carry forward of adjustments or Condition 6.2(l) (*Modifications*) or, where comprising Shares, the fact that the consideration per Share receivable therefor is at least 95 per cent. of the Current Market Price per Share at the relevant time for determination thereof pursuant to the relevant provisions of Condition 6.2 (*Adjustment of Conversion Price*), otherwise result, in an adjustment to the Conversion Price; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) without prejudice to any rule of law or legislation, the conversion of Shares into, or the issue of any Shares in, uncertificated form (or the conversion of Shares in uncertificated form to certificated form) or the amendment of the constitutional documents of the Issuer to enable title to securities (including Shares) to be evidenced and transferred without a written instrument or any other alteration to the constitutional documents of the Issuer made in connection with the matters described in this Condition 11(b) or which is supplemental or incidental to any of the foregoing (including any amendment made to enable or facilitate procedures relating to such matters and any amendment dealing with the rights and obligations of holders of Securities, including Shares, dealt with under such procedures); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) any issue of equity shares or modification of rights attaching to the Shares, where prior thereto the Issuer shall have instructed an Independent Adviser to determine what (if any) adjustments should be made to the Conversion Price as being fair and reasonable to take account thereof and such Independent Adviser shall have determined either that no adjustment is required or that an adjustment resulting in a decrease in the Conversion Price is required and, if so, the new Conversion Price as a result thereof and the basis upon which such adjustment is to be made and, in any such case, the date on which the adjustment shall take effect (and so that the adjustment shall be made and shall take effect accordingly); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) any alteration to the constitutional documents of the Issuer made in connection with the matters described in this Condition 11 or which is supplemental or incidental to any of the foregoing (including any amendment made to enable or facilitate procedures relating to such matters and any amendment dealing with the rights and obligations of holders of Securities, including Shares, dealt with under such procedures); or

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) any amendment of the constitutional documents of the Issuer following or in connection with a Change of Control to ensure that any Bondholder exercising Conversion Rights where the Conversion Date falls on or after the occurrence of a Change of Control will receive, in whatever manner, the same consideration for the Shares arising on such exercise as it would have received in respect of any Shares had such Shares been submitted into, and accepted pursuant to, the relevant offer or tender (a "**Change of Control Conversion Right Amendment** "); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(viii) a Permitted Issue;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) not issue any other class of equity shares nor any rights or options in respect thereof, in each case without the prior consent of the Majority Bondholders;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) except as part of or in connection with or pursuant to any employee, contractor, director or executive share or option or incentive scheme (whether for all employees, contractors, directors or executives or any one or more of them), procure that no Securities which were originally issued (whether issued by the Issuer or any Subsidiary of the Issuer or procured by the Issuer or any Subsidiary of the Issuer to be issued or issued by any other person pursuant to any arrangement with the Issuer or any Subsidiary of the Issuer) without rights to convert into, or exchange or subscribe for, Shares shall subsequently be granted such rights exercisable at a consideration per Share which is less than 95 per cent. of the Current Market Price per Share at the relevant time for determination thereof pursuant to the relevant provisions of Condition 6.2 (*Adjustment of Conversion Price*) unless the same gives rise (or would, but for the provisions of Condition 6.7 (*Rounding Down and Notice of Adjustment to the Conversion Price*) relating to roundings and minimum adjustments or the carry forward of adjustments or Condition 6.2(l) (*Modifications*), give rise) to an adjustment to the Conversion Price and that at no time shall there be in issue Shares of differing nominal values, save where such Shares have the same economic rights;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) not make any issue, grant or distribution or take or omit to take any other action if the effect thereof would be that, on the exercise of Conversion Rights or any Share Settlement Option, Shares could not, under any applicable law then in effect, be legally issued as fully paid;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) not reduce its total issued shares, share capital, share premium account, or any uncalled liability in respect thereof, or any non-distributable reserves, except:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) pursuant to the terms of issue of the relevant shares; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) by means of a purchase or redemption of shares of the Issuer to the extent permitted by applicable law; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) where the reduction does not involve any distribution of assets to Shareholders; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) to create distributable or non-distributable reserves, or (as relevant) to create additional issue premiums;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) absorb accounting losses recognised by the Issuer to create a reserve to absorb foreseeable accounting losses or to create an unavailable reserve in accordance with the Belgian Companies and Associations Code; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) by way of transfer to reserves as permitted under applicable law; or

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) where the reduction is permitted by applicable law and the Bondholders are advised by an Independent Adviser, acting as an expert, that in its opinion the interests of the Bondholders will not be materially prejudiced by such reduction; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(viii) where the reduction is permitted by applicable law and results (or, in the case of a reduction in connection with a Change of Control, will result) in (or would, but for the provisions of Condition 6.7 (*Rounding Down and Notice of Adjustment to the Conversion Price*) relating to roundings or the carry forward of adjustments, result in) an adjustment to the Conversion Price or is (or, in the case of a reduction in connection with a Change of Control, will be) otherwise taken into account for the purposes of determining whether such an adjustment should be made,

provided that, without prejudice to the other provisions of these Conditions, the Issuer may exercise such rights as it may from time to time be entitled pursuant to applicable law to purchase, redeem or buy back its Shares and any depositary or other receipts or certificates representing Shares without the consent of Bondholders;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) if any offer is made to all (or as nearly as may be practicable all) Shareholders (or all (or as nearly as may be practicable all)) Shareholders other than the offeror and/or any parties acting in concert with the offeror (as defined in Article 3, paragraph 1, 5° of the Belgian law of 1 April 2007 on public takeover bids or any modification or re-enactment thereof) to acquire the whole or any part of the issued Shares, or if any person proposes a scheme with regard to such acquisition, give notice of such offer or scheme to the Bondholders in accordance with Condition 16 (*Notices*) at the same time as any notice thereof is sent to the Shareholders (or as soon as practicable thereafter) that details concerning such offer or scheme may be obtained from the Issuer and, where such an offer or scheme has been recommended by the board of directors of the Issuer, or where such an offer has become or been declared unconditional in all respects or such scheme has become effective, use all reasonable endeavours to procure that a like offer or scheme is extended to Bondholders and to the holders of any Shares issued during the period of the offer or scheme arising out of the exercise of the Conversion Rights pursuant to these Conditions (which like offer or scheme to Bondholders shall entitle Bondholders to receive the same type and amount of consideration they would have received had they held the number of Shares to which such Bondholders would be entitled assuming Bondholders were to exercise their Conversion Rights in a Relevant Event Period), provided that, for the avoidance of doubt, this undertaking of the Issuer shall not restrict or prevent the Issuer or its board of directors from co-operating in relation to, or recommending to its shareholders the acceptance of, such a takeover bid in circumstances where (despite the Issuer using all reasonable endeavours as set out above) the bidder does not extend to the Bondholders (or any of them) an offer or proposal as set out above;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) use its best efforts to ensure that the Shares issued and/or transferred and delivered upon exercise of Conversion Rights (if any) will, as soon as is practicable, be listed and admitted to trading on the Relevant Stock Exchange and will be listed, quoted or dealt in, as soon as is reasonably practicable, on any other stock exchange or securities market on which the Shares may then be listed or quoted or dealt in (but so that this undertaking shall be considered as not being breached as a result of a Change of Control (whether or not recommended or approved by the board of directors of the Issuer) that causes or gives rise to, whether following the operation of any applicable compulsory acquisition provision or otherwise, (including at the request of the person or persons Controlling the Issuer as a result of the Change of Control) a de-listing of the Shares);

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) use its best efforts to ensure, at its own cost, that its issued and outstanding Shares are admitted to listing on a regulated, regularly operating, recognised stock exchange, multilateral trading facility or securities market (but so that this undertaking shall be considered as not being breached as a result of a Change of Control (whether or not recommended or approved by the board of directors of the Issuer) that causes or gives rise to, whether following the operation of any applicable compulsory acquisition provision or otherwise, (including at the request of the person or persons Controlling the Issuer as a result of the Change of Control) a de-listing of the Shares);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(j) procure that it shall not become domiciled or resident in or subject generally to the taxing authority of any jurisdiction (other than Belgium or within Belgium) unless:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) it would not thereafter be required pursuant to then current laws and regulations to make any greater withholding or deduction for or on account of any taxes, duties, assessments or governmental charges of whatever nature imposed or levied by or on behalf of such jurisdiction or any applicable sub-division thereof or therein having power to tax; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) holders of the Bonds (whether upon transfer of Bonds or otherwise) would not thereafter be required to pay any additional stamp, issue, transfer, documentary or other similar taxes and duties,

in each case in respect of any payment on or in respect of the Bonds or the Bond Documents, or the transfer of any Bonds, (as applicable) than would be the case were the Issuer to remain domiciled and resident solely within Belgium;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(k) at all times:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) maintain and ensure sufficient approvals and authorisations to enable the issue of Shares as required pursuant to these Conditions (and ignoring, for the purposes of this Condition 11(k) (*Undertakings*), the provisions of Condition 12 (*Regulatory Share Cap*)) upon the exercise of Conversion Rights and any Share Settlement Option in respect of the Bonds (including Further Bonds) which, for the avoidance of doubt, shall include the satisfaction of any requirements on the Issuer to publish a prospectus or other offer document in accordance with Regulation (EU) 2017/1129 and/or the rules of any Relevant Stock Exchange; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) keep available for issue, free from pre-emptive or other preferential rights out of its authorised but unissued Shares to enable the issue of Shares as required pursuant to these Conditions (and ignoring, for the purposes of this Condition 11(k), the provisions of Condition 12 (*Regulatory Share Cap*)) upon the exercise of Conversion Rights and any Share Settlement Option in respect of all the Bonds (including any Further Bonds) then outstanding and all other rights of subscription and exchange for Shares, to be satisfied in full.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(l) with respect to any calculation, determination, verification or adjustment performed by the Calculation Agent or an Independent Adviser at the instruction of the Issuer, promptly notify or procure that the Issuer promptly notifies the Bondholders thereof including all relevant details of such calculation, determination or verification and, upon request from any Bondholder, confirm to the Bondholders (and with notice to the Calculation Agent) the Conversion Price then in effect and details of any relevant prior calculations, determinations, verifications or adjustments as such Bondholder may require;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(m) promptly upon:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the Issuer becoming aware that a Free Float Event may have occurred (or would be likely to have occurred, if an Independent Adviser had been requested to make such determination), acting reasonably, based on publicly available information; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) a request being made by the Majority Bondholders (acting reasonably),

the Issuer shall instruct an Independent Adviser to make a determination as to the number of Shares comprising the Free Float;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(n) unless to do so shall be in breach of applicable law, promptly notify each Bondholder in accordance with Condition 16 (*Notices*) of the occurrence of any Share Settlement Liquidity Event, any Potential Event of Default or any Event of Default;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(o) so far as permitted by applicable law and any applicable contractual obligations of confidentiality, at any time upon request from holders of least one-tenth in principal amount of the Bonds then outstanding, as soon as practicable furnish to each Bondholder such information or materials as may be relevant to the operation of any of the provisions in the Bond Documents, including but not limited to any potential Relevant Event or Share Settlement Liquidity Event and the relevant supporting calculations, evidence of the Issuer's due and punctual performance of its obligations under the Bonds and the Bond Documents, provided that the Issuer shall not (without first entering into a separate confidentiality agreement with the relevant Bondholders) furnish any such information to the relevant Bondholders if it is reasonably expected to constitute Restricted Information; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(p) &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) use its best efforts to ensure that the Change of Control Resolutions are presented to the Shareholders of the Issuer in a general meeting of Shareholders before the Longstop Date; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) promptly after such approval by the general meeting of Shareholders and before the Longstop Date, file a copy of such Change of Control Resolutions with the clerk's office of the competent Enterprise Court in accordance with the provisions of the Belgian Companies and Associations Code.

**12.** **Regulatory Share Cap**

Notwithstanding anything herein to the contrary, the Issuer shall not be obligated to settle any obligation under these Conditions in Shares (including any Share Settlement of interest or principal including by way of the Issuer treating an issue of Shares as a conversion of the relevant amounts due under the Bonds into Shares) if and to the extent such settlement in Shares would cause the issue, conversion or delivery of more Shares than permitted by applicable Belgian law, in which case the Issuer shall instead settle such obligations in cash as if it had made a Cash Alternative Election (and such Shares which are not issued owing to the foregoing are deemed to be Cash Settled Shares, and the date by which such Shares would otherwise have been required to be delivered deemed to be the Conversion Date for the purpose of calculating the Cash Alternative Amount) pursuant to Condition 6.10 (*Cash Alternative Election*) in respect thereof.

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**13.** **Prescription**

Claims against the Issuer for payment in respect of the Bonds shall be prescribed and become void unless made within 10 years (in the case of principal or any other amount (other than interest)) or five years (in the case of interest) from the appropriate Relevant Date in respect of such payment.

Claims in respect of any other obligation in respect of the Bonds, including delivery of Shares, shall be prescribed and become void unless made within three years following the due date for performance of the relevant obligations.

**14.** **Replacement of Bond Certificates**

If any Bond Certificate is lost, stolen, mutilated, defaced or destroyed, it may be replaced by the Issuer subject to and in accordance with Clause 4.6 (*Replacement of Bond Certificates*) of the Bond Instrument.

**15.** **Amendment and Waiver**

**15.1** **Amendment**

Subject to Condition 15.2 (*Reserved Matters*), the Bonds and the Bond Documents may be amended, or waivers or consents given in respect thereof, with the agreement of the Issuer and the Majority Bondholders and (without prejudice to the terms of the Calculation Agency Agreement) any such amendment, waiver or consent will be binding on all Bondholders and shall be notified by the Issuer to Bondholders as soon as practicable.

**15.2** **Reserved Matters**

The Issuer shall not agree to make any amendment, and no waiver or consent shall be effective, in respect of any Bondholder Reserved Matter, without the consent of the holders of at least 75 per cent. in principal amount of the Bonds outstanding.

**15.3** **Voting Evidence**

In relation to any consent to be provided by Bondholders in accordance with the Bonds or the relevant Bond Documents, the Issuer shall provide or procure the provision of evidence satisfactory to each Bondholder (in each case acting reasonably) that specifies:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the principal amount outstanding held by each Bondholder that delivered an instruction to consent, abstain or dissent to any proposal; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the principal amount outstanding of Bonds held by or on behalf of the Issuer or any of its Subsidiaries or any of their respective affiliates (as referred to in the definition of "outstanding" in Condition 3 (*Definitions*)).

**16.** **Notices**

All notices required to be given to the Issuer or any Bondholder pursuant to these Conditions will (unless otherwise provided in these Conditions) be given:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) in the case of the initial Bondholder, in accordance with the terms of the Subscription Agreement; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) in the case of any New Holder (as defined in the Bond Instrument), in writing by letter or email to the address specified in each duly executed and completed form of transfer,

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or, in each case, to such other contact details as any Bondholder may subsequently provide in writing to the Issuer from time to time in accordance with the Bond Instrument.

Any notice given under these Conditions shall take effect, in the case of a letter, at the time of delivery, or in the case of email transmission, at the time of despatch (unless a delivery failure notification is received by the sender within 12 hours of sending such communication, in which case such notice shall be deemed not to have taken effect). If, only in respect of matters where Brussels business days are specified, such delivery or despatch is made after 5:00 p.m. (Brussels time) or on a day which is not a Brussels business day, such delivery shall be deemed to have been made on the next following Brussels business day, as applicable.

If any notice required to be given pursuant to these Conditions would otherwise contain any Restricted Information then the Issuer shall simultaneously with such notice make a public announcement containing all such Restricted Information such that the notice to the Bondholders shall not contain any Restricted Information, unless otherwise approved in writing by the Majority Bondholders, or the Issuer has delayed the disclosure of Restricted Information pursuant to Regulation 596/2014/EU, in which case the Issuer shall inform the Bondholders of the nature of such Restricted Information prior to providing the relevant notice and confirm in writing whether each Bondholder is willing to receive such Restricted Information and comply with applicable laws and regulations stipulating the receipt and restrictions related thereto.

The Issuer shall send a copy of all notices given by it to Bondholders (or a Bondholder) pursuant to these Conditions promptly to the Calculation Agent.

**17.** **Beneficial Ownership of Shares**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) If, at any time, the Issuer shall become a Reporting Company in the United States then, notwithstanding any other provision of these Conditions or the Bond Documents, each Bondholder, together with its other Attribution Parties, shall not at any time own or acquire the beneficial ownership of more than 9.99 per cent. of the issued and outstanding Shares in the Issuer (the "**Maximum Percentage** ").

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) For the purposes of paragraph (a) above, the aggregate number of Shares beneficially owned by a Bondholder and its other Attribution Parties shall include the number of Shares held by such Bondholder and all other Attribution Parties, plus the number of Shares issuable upon the exercise of Conversion Rights or Share Settlement Option in respect of any Bond, in each case with respect to which the determination of such provision is being made, but shall exclude Shares which would be issuable upon:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) conversion of the remaining, non-converted portion of any Bond beneficially owned by the initial Bondholder or any of the other Attribution Parties, as the case may be, including any Share Settlement Option under the Bonds; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the exercise or conversion of the unexercised or non-converted portion of any other Securities (as defined in the Conditions) of the Issuer that are beneficially owned by a Bondholder or any other Attribution Party, subject to a limitation on conversion or exercise analogous to the limitation contained in paragraph (a) above.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) For the purposes of paragraph (a) above, beneficial ownership shall be calculated in accordance with Section 13(d) of the Exchange Act. For the purposes of determining the number of outstanding Shares a Bondholder may acquire upon the conversion of any Bond or following any exercise of any Share Settlement Option under the Bonds without

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exceeding the Maximum Percentage, such Bondholder may rely on the number of outstanding Shares as reflected in (i) the Issuer's most recent Annual Report on Form 20-F, Report on Form 6-K or other public filing with the SEC, as the case may be, (ii) a more recent public announcement by the Issuer or (iii) any other written notice by the Issuer setting forth the number of Shares outstanding (in either case, the "**Reported Outstanding Share Number**").

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) If the Issuer receives a Conversion Notice from a Bondholder at a time when the actual number of outstanding Shares is less than the Reported Outstanding Share Number, the Issuer shall notify such Bondholder in writing of the number of Shares then outstanding and, to the extent that such exercise of Conversion Rights would otherwise cause that Bondholder's beneficial ownership, as determined pursuant to this Condition, to exceed the Maximum Percentage, the relevant Bondholder must notify the Issuer of a reduced number of Shares to be purchased pursuant to such exercise of Conversion Rights.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) The Issuer shall promptly on demand by any Bondholder (and in any event by no later than one Brussels business day after demand) confirm in writing to such Bondholder the relevant number of Shares outstanding at such date. The number of outstanding Shares shall be determined after giving effect to the conversion or exercise of Securities of the Issuer, including any Bond and any Share Settlement Option, by the relevant Bondholder and any other Attribution Party since the date as of which the Reported Outstanding Share Number was reported. In the event that the issuance or transfer and delivery of Shares to a Bondholder upon conversion of any Bond or exercise of any Share Settlement Option results in that Bondholder and the other Attribution Parties being deemed to beneficially own, in the aggregate, more than the Maximum Percentage of the number of outstanding Shares (as determined under Section 13(d) of the Exchange Act), the number of Shares so issued or delivered by which that Bondholder's and the other Attribution Parties' aggregate beneficial ownership exceeds the Maximum Percentage (the "**Excess Shares**") shall be deemed null and void and shall be cancelled ab initio, and such Bondholder shall not have the power to vote or to transfer the Excess Shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) The Shares issuable pursuant to the terms of any Bond in excess of the Maximum Percentage shall not be deemed to be beneficially owned by a Bondholder for any purpose including for purposes of Section 13(d) or Rule 16a-1(a)(1) of the Exchange Act. No prior inability to convert any Bond shall have any effect on the applicability of the provisions of this Condition 17 with respect to any subsequent determination of convertibility. The provisions of this Condition shall be construed and implemented in a manner otherwise than in strict conformity with the terms of this Condition 17 to the extent necessary to correct this Condition 17 (or any portion of this Condition 17) which may be defective or inconsistent with the intended beneficial ownership limitation contained in this Condition 17 or to make changes or supplements necessary or desirable to properly give effect to such limitation.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) The limitation contained in this Condition 17 may not be waived.

**18.** **Further Issues**

The Issuer may not create and issue Further Bonds except with the prior written approval of the Majority Bondholders. Any Further Bonds shall be constituted by a deed supplemental to the Bond Instrument.

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**19.** **Contracts (Rights of Third Parties) Act 1999**

Other than the Bondholders, no person shall have any right to enforce any term or condition of the Bonds under the Contracts (Rights of Third Parties) Act 1999, or, with respect to provisions governed by Belgian law under Condition 20 (*Governing Law*), under any similar applicable Belgian law (including, without limitation, under Article 5.107 of the Belgian Civil Code) and no such right shall be inferred or implied from the Conditions either.

**20.** **Governing Law**

These Conditions, the Bond Instrument and the Bonds and any non-contractual obligations arising out of or in connection with them are governed by, and shall be construed in accordance with, English law, except that the provisions relating to ranking, status and subordination in Condition 1.3 (*Status*) and Condition 1.4 (*Subordination*) and the rights and obligations of the Issuer and the Bondholders in respect thereof, and any non-contractual obligations arising out of or in connection with them, shall be governed by and construed in accordance with the laws of Belgium.

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**Schedule 3** 

**Form of Register**

**Nyxoah SA**

**€22,500,000 AMORTISING SENIOR UNSECURED CONVERTIBLE BONDS DUE 2028**

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| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| **Name:** | **[**●**]** | **[**●**]** |  |  |  |  |  |
| **Contact<br>Details:** | *[Insert Address]*<br>*[Attention]*<br>*[Email]* | *[Insert Address]*<br>*[Attention]*<br>*[Email]* |  |  |  |  |  |
| **Initial<br>Principal<br>Amount:** | €[●] | €[●] |  |  |  |  |  |
| **DATE** | **CERT<br>NUMBER** | **ACQUISITIONS** | **DISPOSALS** | **REDEMPTIONS /<br>AMORTISING<br>PRINCIPAL<br>PAYMENTS /<br>CANCELLATIONS** | **CONVERSIONS /<br>CONVERSION<br>PRICE / SHARE<br>SETTLEMENTS** | **DEFERRALS /<br>ADVANCEMENTS** | **BALANCE** |
| [●] | [●]<br>[*Insert details of replacement Bond Certificates, if any*] | €[●] from [*insert name of transferor and details of transaction*] | €[●] from [*insert name of transferee and details of transaction*] | €[●]<br>[*Specify details of all amortising payments of principal under the Bonds and all redemptions or cancellations of Bonds*] | €[●]<br>[*Specify details of all conversions of Bonds under the Conversion Right or upon exercise of any Share Settlement Option (as defined in the Conditions) of payments thereunder*] | €[●]<br>[*Specify details of any deferrals or advancements of Amortised Payment Amounts (as defined in the Conditions)*] | €[●] |

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**Schedule 4** 

**Regulations Concerning Transfers and Registration of the Bonds**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. The Issuer shall maintain or procure the maintenance of a Register in respect of the Bonds and enter in it or procure the entrance into it of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the initial principal amount of the Bonds, all amortising payments of principal, and the remaining principal amount of the Bonds at any time;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the date of issue of the Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) all subsequent transfers and changes of ownership of Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) the names, contact and book-entry account details of the holders of the Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) the Conversion Price (as defined in the Conditions) in effect at any time;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) details of all conversions of Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) details of all redemptions and cancellations of Bonds or replacements of Bond Certificates; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) in respect of each Bond, details of the exercise of any Share Settlement Option (as defined in the Conditions) or any deferrals or advancements or of Amortised Payment Amounts (as defined in the Conditions) and the consequential payment dates in respect thereof.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. The Issuer shall maintain or procure the maintenance of the Register and update it, or procure that it is updated, on a regular basis to reflect any changes to the information specified in paragraph 1 above and any changes in holdings or ownership.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3. Subject to Clause 4.4 (*Closed Periods*) and 6.2 (*Permitted Transfers*), Bonds may be transferred by execution of the relevant Form of Transfer under the hand of the transferor and the transferee or, where the transferor or transferee is a corporation, under its common seal or under the hand of two of its officers duly authorised in writing. Where and to the extent that any duty or tax is required to be paid before the effect of a transfer may lawfully be registered in the Register, the Issuer shall not be required to take any action in respect of such transfer (whether under this Schedule or under Clause 6.2 (*Permitted Transfers*) or otherwise) unless and until it has received evidence to its satisfaction that such tax or duty has been paid.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4. The Bond Certificate issued in respect of the Bonds to be transferred must be surrendered for registration, together with the duly completed and executed form of transfer endorsed thereon, and together with such evidence as the Issuer may reasonably require to prove the title of the transferor and the authority of the persons who have executed the form of transfer.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5. The executors or administrators of a deceased Bondholder of a Bond shall be the only persons recognised by the Issuer as having any title to such Bond.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6. Any person becoming entitled to any Bonds in consequence of the bankruptcy of the Bondholder of such Bonds may, upon producing such evidence that it holds the position in respect of which it proposes to act under this paragraph or of its title as the Issuer reasonably may require (including legal opinions), become registered it as the Bondholder of such Bonds or, subject to the provisions of these Regulations, the Conditions and the Bond Instrument as to transfer, may transfer such

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

Bonds. The Issuer shall be at liberty to retain any amount payable upon the Bonds to which any person is so entitled until such person is so registered or duly transfers such Bonds.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7. Where there is more than one transferee (to hold other than as joint Bondholders), separate Forms of Transfer must be completed in respect of each new holding.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8. Joint holdings of Bonds shall not be permitted and the entries in the Register shall identify a single person as the Bondholder of each Bond.

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**Schedule 5** 

**Form of Officer's Certificate**

[*Letterhead of the Issuer*]

**Officer's Certificate**

**CVI Investments, Inc.**

c/o Heights Capital Management, Inc.

101 California Street, Suite 3250

San Francisco, CA 94111

United States of America

[*Date*]

To whom it may concern,

**Nyxoah SA (the "Issuer")**

**€22,500,000 Amortising Senior Unsecured Convertible Bonds due 2028 (the "Bonds")**

In accordance with Condition [2.3(a)] (*Information and General Undertakings*) of the terms and conditions (the "**Conditions**") set out in Schedule 2 (*Terms and Conditions of the Bonds*) of the Bond Instrument dated 18 December 2025 and made by the Issuer (as amended or supplemented from time to time), I, the undersigned, being a duly authorised officer of the Issuer, hereby certify that since [*the date of the last certificate delivered in accordance with Condition [●]]/[the Issue Date*]<sup>2</sup>:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) [no new Security Interests have been created over any assets of the Borrower and/or any of its Subsidiaries]/[the following Security Interests have been created over the assets of the Borrower and its Subsidiaries: [ *insert detail* ]];

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the terms of any Financial Indebtedness incurred by the Borrower and/or any of its Subsidiaries do not, expressly or impliedly, limit, impair or otherwise restrict the ability of the Borrower to at all times perform and comply with its payment, indemnity and/or any other obligations under the Conditions or the terms of any Bond Document;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) no Relevant Event has occurred; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) no Event of Default or Potential Event of Default has occurred and is continuing.

Terms used herein and defined in the Conditions are used herein as so defined.

Yours faithfully,

---

| |
|:---|
| *duly authorised*  |
| for and on behalf of |
| **NYXOAH SA** |

---

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<sup>2</sup> *Note: In case of the first certificate, the certifications must be made from the Issue Date. Delete as applicable.*

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**Schedule 6** 

**Form of Conversion Notice**

To: **NYXOAH SA** (the "**Issuer**")

*With copy to: Conv-Ex Advisors Limited*

**€22,500,000 Amortising Senior Unsecured Convertible Bonds due 2028 (the "Bonds")**

All terms used herein but not defined shall have the same meanings as set out in the Bond Instrument relating to the Bonds dated 18 December 2025 (as amended or supplemented from time to time) made by the Issuer (the "**Bond Instrument**") and the terms and conditions of the Bonds (the "**Conditions**").

We, the undersigned, being the holder(s) of the Bonds specified below hereby irrevocably elect [to convert the principal amount of]<sup>3</sup>/[contribute in kind the receivables outstanding under]<sup>4</sup> such Bonds as specified below for such number of Shares in the Issuer as is calculated at the Conversion Price in accordance with the Conditions.

The total principal amount and, where applicable, serial numbers of Bonds to which the Conversion Notice applies are as follows:

Number of Bonds: _______________________

Total [principal amount]<sup>5</sup>/[receivables]<sup>6</sup>:€_______________________

Serial number of Bond Certificate:_______________________

Share Line (US / Belgian / Combination (*specify*)):_______________________

We direct the Issuer to allot the Shares to be issued pursuant to this exercise [in accordance with the Payment Details] / [in the following numbers to the following proposed allottees]:

Name of proposed allottee:_______________________

Address of proposed allottee:_______________________

Book-entry account details:_______________________

_______________________

_______________________

The Bond Certificate(s) in respect of the Bonds [converted hereby]<sup>7</sup>/[in respect of which receivables have been contributed in kind]<sup>8</sup> accompany this Conversion Notice (which may be by email of a copy).

At the time of delivering (and where applicable, signing) this Conversion Notice, we hereby: (a) confirm that the Bonds to which this Conversion Notice relates are free from all liens, charges, encumbrances and

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<sup>3</sup> *Include in the case of an exercise of a Bond Conversion Right.*

<sup>4</sup> *Include in the case of an exercise of an Amortisation Conversion Right.*

<sup>5</sup> *Include in the case of an exercise of a Bond Conversion Right.*

<sup>6</sup> *Include in the case of an exercise of an Amortisation Conversion Right.*

<sup>7</sup> *Include in the case of an exercise of a Bond Conversion Right.*

<sup>8</sup> *Include in the case of an exercise of an Amortisation Conversion Right.*

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any other third party rights, and (b) confirm that any third-party nominee whose account the Shares are to be delivered, if applicable, have consented to the same.

This notice and any non-contractual obligations arising out of or in connection with it shall be governed by, and construed in accordance with, English law.

Yours faithfully,

---

| |
|:---|
| *duly authorised* |
| for and on behalf of |
| **[NAME OF BONDHOLDER]** |

---

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**Schedule 7** 

**Form of Amortised Payment Advancement Notice and Deferral Notice**

To: **NYXOAH SA** (the "**Issuer**")

*With copy to: Conv-Ex Advisors Limited*

**€22,500,000 Amortising Senior Unsecured Convertible Bonds due 2028 (the "Bonds")**

All terms used herein but not defined shall have the same meanings as set out in the Bond Instrument relating to the Bonds dated 18 December 2025 (as amended or supplemented from time to time) made by the Issuer (the "**Bond Instrument**") and the terms and conditions of the Bonds (the "**Conditions**").

<sup>9</sup>[We, the undersigned, being the Majority Bondholder(s) of the Bonds specified below hereby elect to exercise our right to bring forward the payment of the Amortised Payment Amount(s) to the Accelerated Amortisation Payment Date as specified below in accordance with the Conditions:

Amortised Payment Amount(s):€_______________________

Accelerated Amortisation Payment Date:_______________________<sup>10</sup>

Accrued Interest:€_______________________

Current Maturity Date:_______________________

New Maturity Date:_______________________

Share Line (US / Belgian / Combination (*specify*)):_______________________

You are reminded that any exercise of the Share Settlement Option in respect of such Accelerated Amortised Payment Amount(s) must be notified to us by no later than 5:00 p.m. (New York time) on the second Qualifying Business Day prior to such Accelerated Amortisation Payment Date in accordance with the Conditions.]

<sup>11</sup>[We, the undersigned, being the Majority Bondholder(s) of the Bonds specified below hereby elect to exercise our right to defer the payment of the Amortised Payment Amount(s) as specified below in accordance with the Conditions:

Deferred Amortised Payment Amount:€_______________________

Deferred Amortisation Payment Date:_______________________

Final Maturity Date:_______________________

This notice and any non-contractual obligations arising out of or in connection with it shall be governed by, and construed in accordance with, English law.

Yours faithfully,

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<sup>9</sup> *Note: Applicable in respect of an Amortised Payment Advancement.*

<sup>10</sup> *Note: This date shall not be earlier than the two Brussels business day following the date on which this Notice is given.*

<sup>11</sup> *Note: Applicable in respect of an Amortised Payment Deferral.*

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

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| |
|:---|
| *duly authorised*  |
| for and on behalf of |
| **[NAME OF BONDHOLDER]** |

---

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**Schedule 8** 

**Form of Scheduled Amortised Payment Notice**

To: **NYXOAH SA** (the "**Issuer**")

*With copy to: Conv-Ex Advisors Limited (via email: calculation.agent@conv-ex.com)*

**€22,500,000 Amortising Senior Unsecured Convertible Bonds due 2028 (the "Bonds")**

All terms used herein but not defined shall have the same meanings as set out in the Bond Instrument relating to the Bonds dated 18 December 2025 (as amended or supplemented from time to time) made by the Issuer (the "**Bond Instrument**") and the terms and conditions of the Bonds.

Reference is made to the Amortised Payment Amount on the Scheduled Amortisation Payment Date as specified below in accordance with the Conditions:

Amortised Payment Amount:€_______________________

Accrued Interest:€_______________________<sup>12</sup>

Scheduled Amortisation Payment Date [and_______________________

Interest Payment Date]:

The Issuer has exercised the Share Settlement Option in respect of such Amortised Payment Amount in accordance with the Conditions.

This notice and any non-contractual obligations arising out of or in connection with it shall be governed by, and construed in accordance with, English law.

Yours faithfully,

---

| |
|:---|
| *duly authorised* |
| for and on behalf of |
| **[NAME OF BONDHOLDER]** |

---

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<sup>12</sup> *Not applicable if Interest Share Option is not exercised.*

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**Schedule 9** 

**Form of Tax Status Certificate**

Established in accordance with Article 117, §6ter (jo. Article 118, §1, 1° and Article 107, §2, 10°) of the Royal Decree taken in execution of the Income Tax Code 1992 (RD/ITC 1992)

The undersigned, [_________________________] (*name*), [______________________] (*address*), as the recipient of the income paid or attributed by **NYXOAH SA**, a company incorporated under the laws of Belgium with registration number 0817.149.675,

confirms:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) to be a non-resident of Belgium, i.e.,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a. not to have her/his residence or center of wealth in Belgium

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b. not to have its statutory seat, principal establishment or a seat of management in Belgium

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) to be the legal owner (or usufructuary) of the notes during the entire period to which the interest pertains;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3) not to use the notes for a professional activity in Belgium (i.e., the notes are not invested in a Belgian permanent establishment); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(4) to be: [ *please check at least one, as appropriate* ]

☐ a company that is subject in its country of residence to an income tax, the provisions of which are not considerably more advantageous than those of Belgium;

☐ a company the shares of which are not held for at least 50% by Belgian individual residents;

☐ an investment company which has made a public call for savings;

☐ an individual;

☐ a legal entity which is not involved in profit-making concerns of operations.

Signed at ..............................................................................on the date of ....................................................

By:

Name:

Title:

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**In Witness Whereof** this Deed has been executed and delivered as a deed on the date stated at the beginning.

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| | | | |
|:---|:---|:---|:---|
| **NYXOAH SA** |  |  |  |
| &nbsp;&nbsp;as ***Issuer*** | ![Graphic](nyxh-20251231xex4d22008.jpg) | By: | /s/ John Landry |
|  | ![Graphic](nyxh-20251231xex4d22008.jpg) | Name: | John Landry |
|  | ![Graphic](nyxh-20251231xex4d22008.jpg) | Title: | CFO |

---

[*Signature page to the Bond Instrument*]

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## Exhibit 4.23

**Exhibit 4.23**

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

*EXECUTION VERSION*

![Graphic](nyxh-20251231xex4d23001.jpg)

**Dated 02 February 2026**

**First Supplemental Bond Instrument**

relating to €22,500,000 Amortising Senior Unsecured Convertible Bonds due 2028

by

**Nyxoah SA**

as Issuer

White & Case LLP

5 Old Broad Street

London EC2N 1DW

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**Table of Contents**

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| | | |
|:---|:---|:---|
|  |  | **Page** |
| 1. | Definitions and Interpretation | 2 |
| 2. | Amendments to the Original Bond Instrument | 2 |
| 3. | Benefit of this Deed | 3 |
| 4. | Amendments and Waivers | 3 |
| 5. | Remedies and Waivers | 3 |
| 6. | Notices | 3 |
| 7. | Severability | 4 |
| 8. | Counterparts | 4 |
| 9. | Governing Law and Jurisdiction | 4 |
| **Schedule 1** **Terms and Conditions of the Bonds** | **Schedule 1** **Terms and Conditions of the Bonds** | **6** |

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(i) ------

***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**This first supplemental bond instrument** (this "**Deed**" or the "**First Supplemental Bond Instrument**") is made on 02 February 2026

**By:**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) **NYXOAH SA**, a public limited liability company incorporated and existing under the laws of Belgium whose registered office is at Rue Edouard Belin, 12, 1435 Mont-Saint-Guibert, Belgium, registered with the Crossroads Bank for Enterprises (Kruispuntbank van Ondernemingen/Banque-Carrefour des Entreprises) under number 0817149675 (Register of Legal Entities Brabant Wallon) (the "**Issuer** "),

**In favour of**:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) **THE PERSONS** for the time being and from time to time registered as holders of the Bonds referred to below (the "**Bondholders**" or "**holders** "),

(each a "**Party**" and together the "**Parties**").

**Whereas:**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) On 18 December 2025, the Issuer created and issued, within the framework of the authorised capital granted to its board of directors, Amortising Senior Unsecured Convertible Bonds due 2028 in an aggregate principal amount of €22,500,000 (the "**Bonds** "), which were constituted by and subject to a bond instrument dated 18 December 2025 (the "**Original Bond Instrument**") entered into by the Issuer.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) This First Supplemental Bond Instrument evidences changes made to the terms and conditions of the Bonds as agreed between the Issuer and the then current Bondholders as of the date hereof.

**It is agreed** as follows:

**1.** **Definitions and Interpretation**

**1.1** **Definitions**

Terms defined in the Original Bond Instrument shall have the same meanings where used in this First Supplemental Bond Instrument unless separately defined.

**1.2** **Interpretation**

The rules of interpretation set out in clause 1.2 of the Original Bond Instrument shall apply *mutatis mutandis* in full to this First Supplemental Bond Instrument as if set out herein.

**2.** **Amendments to the Original Bond Instrument**

Without prejudice or limitation to the other provisions of this Deed, the Original Bond Instrument is hereby amended and varied such that references therein to:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) "**Calculation Agency Agreement**" shall mean the calculation agency agreement dated 18 December 2025 between the Issuer and Conv-Ex Advisors Limited as calculation agent, as supplemented by a supplemental agreement dated 02 February 2026;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) "**Conditions**" shall be construed so as to mean the terms and conditions of the Bonds in the form set out in Schedule 1 (*Terms and Conditions of the Bonds*) to this Deed, and

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

Schedule 2 to the Original Bond Instrument is hereby deleted in its entirety and replaced with Schedule 1 (*Terms and Conditions of the Bonds*) to this Deed; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) "**Deed** ", "**Bond Instrument**" and "**this Deed**" shall be read as references to the Original Bond Instrument as supplemented by this First Supplemental Bond Instrument.

**3.** **Benefit of this Deed**

**3.1** **Deed Poll**

This Deed shall take effect as a deed poll for the benefit of the Bondholders from time to time.

**3.2** **Benefit**

This Deed shall ensure to the benefit of the Bondholders and each of their (and any subsequent) successors and assigns, each of which shall be entitled severally to enforce this Deed against the Issuer.

**4.** **Amendments and Waivers**

The provisions of this Deed (including the Conditions) may not be modified, altered, abrogated or added to other than as provided in, and in accordance with, Condition 15 (*Amendment and Waiver*).

**5.** **Remedies and Waivers**

No failure to exercise, and no delay in exercising, on the part of the Bondholders of any right hereunder shall operate as a waiver thereof nor shall any single or partial exercise thereof preclude any other or future exercise thereof or the exercise of any other right. Rights hereunder shall be in addition to all other rights provided by law. No notice or demand given in any case shall constitute a waiver of rights to take other action in the same, similar or other instances without such notice or demand.

**6.** **Notices**

**6.1** **Communications in Writing**

Any communication to be made under or in connection with this Deed or the Bonds shall be made in writing and, unless otherwise stated, may be made by email or letter.

**6.2** **Addresses**

The address and email address (and the department or officer, if any, for whose attention the communication is to be made) of the Issuer for any communication or document to be made or delivered under or in connection with this Deed or the Bonds is:

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| | |
|:---|:---|
| Address:  | [\*\*\*] |
| Email:  | [\*\*\*] |
| Attention:  | [\*\*\*] |

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

or any substitute address or email address or department or officer as the Issuer may notify to the Bondholders by not less than five Business Days' notice.

**6.3** **Effectiveness**

Any notice given under this Deed shall take effect, in the case of a letter, at the time of delivery, or in the case of email transmission, at the time of despatch (unless a delivery failure notification is received by the sender within 12 hours of sending such communication, in which case such notice shall be deemed not to have taken effect). If such delivery or despatch is made after 5:00 p.m. (Brussels time) or on a day which is not a Brussels business day (in respect of matters where only Brussels business days are specified) or Business Day (in respect of all other matters), such delivery shall be deemed to have been made on the next following Brussels business day or Business Day, as applicable.

**7.** **Severability**

If any provision in or obligation under this Deed is or becomes invalid, illegal or unenforceable in any respect under the law of any jurisdiction, that will not affect or impair (a) the validity, legality or enforceability under the law of that jurisdiction of any other provision in or obligation under this Deed, and (b) the validity, legality or enforceability under the law of any other jurisdiction of that or any other provision in or obligation under this Deed.

**8.** **Counterparts**

This Deed may be executed in any number of counterparts, and this has the same effect as if the signatures on the counterparts were on a single copy of this Deed.

**9.** **Governing Law and Jurisdiction**

**9.1** **Governing Law**

This Deed, including any non-contractual obligations arising out of or in connection with this Deed, are governed by, and shall be construed in accordance with, English law, except that the provisions relating to ranking, status and subordination in Condition 1.3 (*Status*) and Condition 1.4 (*Subordination*) and the rights and obligations of the Issuer and the Bondholders in respect thereof, shall be governed by and construed in accordance with the laws of Belgium.

**9.2** **Jurisdiction**

The Issuer agrees for the benefit of each Bondholder that the courts of England shall have exclusive jurisdiction to hear and determine any suit, action or proceedings arising out of or in connection with this Deed (including any non-contractual obligations arising out of or in connection with this Deed) ("**Proceedings**") and, for such purposes, irrevocably submits to the jurisdiction of such courts. Nothing in this paragraph shall (or shall be construed so as to) limit the right of any Bondholder to take Proceedings in any other court of competent jurisdiction, nor shall the taking of Proceedings in any one or more jurisdictions preclude the taking of Proceedings by any Bondholder in any other jurisdiction (whether concurrently or not) if and to the extent permitted by law.

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**9.3** **Appropriate Forum**

For the purpose of Clause 9.2 (*Jurisdiction*), the Issuer irrevocably waives any objection which it might now or hereafter have to the courts of England being nominated as the forum to hear and determine any Proceedings and agrees not to claim that any such court is not a convenient or appropriate forum.

**9.4** **Service of Process**

The Issuer agrees that the process by which any Proceedings are commenced in England pursuant to Clause 9.2 (*Jurisdiction*) may be served on it by being delivered to the attention of Law Debenture Corporate Services Limited at its registered office from time to time. If such person is not or ceases to be effectively appointed to accept service of process on behalf of the Issuer, the Issuer shall promptly appoint a further person in England to accept service of process on its behalf. Nothing in this paragraph shall affect the right of any Bondholder to serve process in any other manner permitted by law.

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**Schedule 1**

**Terms and Conditions of the Bonds**

The issue of the €22,500,000 Amortising Senior Convertible Bonds due 2028 (the "**Bonds**", which expression shall, unless otherwise indicated, include any Further Bonds (as defined below)) was (save in respect of any Further Bonds) effected within the framework of the authorised capital granted by the board of directors of Nyxoah SA (the "**Issuer**") on or around 18 December 2025.

The Bonds are constituted by a Bond Instrument dated 18 December 2025 (the "**Original Bond Instrument**", and as amended, supplemented or amended and restated from time to time, including by a first supplemental bond instrument dated 02 February 2026, the "**Bond Instrument**") made by the Issuer. The statements set out in these Terms and Conditions (the "**Conditions**") are subject to the provisions of the Bond Instrument.

The Issuer has also entered into a calculation agency agreement (as amended, supplemented or amended and restated from time to time, including by an amendment agreement dated 02 February 2026, the "**Calculation Agency Agreement**") dated 18 December 2025 with Conv-Ex Advisors Limited (the "**Calculation Agent**", which expression shall include any successor as calculation agent under the Calculation Agency Agreement) pursuant to which the Calculation Agent will be appointed to make certain calculations in relation to the Bonds. The Bondholders are deemed to have notice of those provisions applicable to them which are contained in the Calculation Agency Agreement.

Capitalised terms used but not defined in these Conditions shall have the meanings attributed to them in the Bond Instrument unless the context otherwise requires or unless otherwise stated.

**1.** **Form, Initial Denomination, Title and Status**

**1.1** **Form and Initial Denomination**

The Bonds are in registered form in initial principal amounts of €100,000 each, as may be reduced from time to time in accordance with Condition 7.1 (*Mandatory Redemption by Amortisation*).

**1.2** **Title**

Title to the Bonds will pass by transfer and registration as described in Clause 4 (*Register and Title*) and Clause 6 (*Transfers of Rights and Obligations*) of the Bond Instrument and Condition 4 (*Registration and Transfer of Bonds*). Each holder of Bonds will (except as otherwise required by law or as ordered by a court of competent jurisdiction) be treated as the absolute owner of such Bond for all purposes (whether or not it is overdue and regardless of any notice of ownership, trust or any interest in such Bond, any writing on the Bond Certificate relating to such Bonds or any notice of any previous loss or theft of such Bond Certificate) and no person will be liable for so treating such holder.

**1.3** **Status**

The Bonds constitute direct, unconditional, (subject to Condition 1.4 (*Subordination*)) unsubordinated and (subject to Condition 2.1 (*Negative Pledge*)) unsecured obligations of the Issuer ranking *pari passu* and rateably, without any preference among themselves, and at least equally with all other existing and future unsecured and unsubordinated obligations of the Issuer but, in the event of an insolvency of the Issuer, save for such obligations that may be preferred by provisions of law that are mandatory and of general application.

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**1.4** **Subordination**

The Bonds shall rank in right and priority of payment immediately after the Issuer's liabilities under the EIB Facility and are postponed and subordinated solely to the Issuer's liabilities under the EIB Facility, except for any obligations mandatorily preferred by law applying to companies generally.

The Bonds shall not be, and are not intended to be, subordinated to any present or future indebtedness, obligations or liabilities of the Issuer, whether senior, *pari passu*, or otherwise, other than the liabilities under the EIB Facility, except for obligations mandatorily preferred by law applying to companies generally.

The Bonds shall rank at least *pari passu* with all other present and future unsecured and unsubordinated liabilities of the Issuer's, except for obligations mandatorily preferred by law applying to companies generally.

**2.** **Covenants**

**2.1** **Negative Pledge**

So long as any Bond remains outstanding (as defined below), the Issuer shall not, and will procure that none of its Subsidiaries will, create or permit to subsist any Security Interest (as defined below) upon the whole or any part of its present or future undertaking, assets or revenues (including any uncalled capital) to secure any Financial Indebtedness or to secure any Financial Indebtedness Guarantee, without at the same time or prior thereto:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) securing the obligations of the Issuer under the Bonds and the Bond Instrument (including these Conditions) equally and rateably therewith; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) providing such other security, guarantees and/or other arrangements (whether or not comprising a Security Interest) for the benefit of Bondholders as may be approved by holders of at least 90 per cent. in principal amount of the Bonds then outstanding,

*provided that:*

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) any entity acquired by the Issuer after the Issue Date may have outstanding Security Interests with respect to Financial Indebtedness and/or any Financial Indebtedness Guarantee or indemnity in respect of such Financial Indebtedness of such entity, so long as any such Security Interest was outstanding on the date on which any such entity became a Subsidiary of the Issuer and was not created in contemplation of any such entity becoming a Subsidiary of the Issuer, or any such Security Interest was created in substitution for or to replace either any such outstanding Security Interest or any such substituted or replacement Security Interest and is not increased in amount after the date that any such entity became a Subsidiary of the Issuer;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) any entity which becomes a Subsidiary of the Issuer or is merged, consolidated or amalgamated into a Subsidiary of the Issuer on or after the Issue Date may have outstanding Security Interests with respect to Financial Indebtedness and/or any Financial Indebtedness Guarantee or indemnity in respect of such Financial Indebtedness of such Subsidiary, so long as any such Security Interest

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) was outstanding on the date on which any such entity became a Subsidiary of the Issuer or was merged, consolidated or amalgamated into a Subsidiary of the Issuer;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) was not created in contemplation of any such entity becoming a Subsidiary of the Issuer or being merged, consolidated or amalgamated into a Subsidiary of the Issuer; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(C) is not increased in amount after the date that any such entity became a Subsidiary of the Issuer or was merged, consolidated or amalgamated into a Subsidiary of the Issuer; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) the Issuer may have, at any time, any Security Interest to secure any Financial Indebtedness or to secure any Financial Indebtedness Guarantee or indemnity in respect of any Financial Indebtedness to the extent that such Security Interest arises by operation of law.

**2.2** **Incurrence of Financial Indebtedness**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) For so long as any Bond remains outstanding, the Issuer shall not, and shall procure that its Subsidiaries shall not, directly or indirectly and at any time, create, incur, assume or otherwise become liable (contingently or otherwise) in respect of any Financial Indebtedness which by their terms carry (directly or indirectly) rights of conversion into, or exchange or subscription for, or the right to otherwise acquire, any shares in the capital of the Issuer or any of its Subsidiaries.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Condition 2.2(a) (*Incurrence of Financial Indebtedness*) shall not prohibit the incurrence by the Issuer of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) Financial Indebtedness represented by the Bonds, if issued, or the Second Tranche Bonds; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) Financial Indebtedness of the Issuer and its Subsidiaries that is outstanding as at the Issue Date.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) For so long as any Bond remains outstanding,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the Issuer shall not, and shall procure that its Subsidiaries shall not, directly or indirectly and at any time, create, incur, assume or otherwise become liable (contingently or otherwise) in respect of any Financial Indebtedness in any amount which by their terms (directly or indirectly) limit or prohibit any term of the Bonds or the Bond Documents, including, without limitation:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) any prohibition on any payment of cash by the Issuer in respect of any obligation under the Bonds or the Bond Documents;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) any limitation on the ability of the Bondholders to exercise Conversion Rights; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(C) any limitation on the ability of the Issuer to deliver Shares in respect of the exercise of any Share Settlement Option; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the Issuer shall not, and shall procure that its Subsidiaries shall not, directly or indirectly and at any time, create, incur, assume or otherwise become liable (contingently or otherwise) in respect of any Financial Indebtedness in any amount which by their terms (directly or indirectly) would rank senior to the Bonds in right of payment.

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**2.3** **Information and General Undertakings**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) For so long as any Bonds are outstanding, the Issuer shall deliver to each Bondholder:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) within 15 Brussels business days following publication of its financial statements for its full financial year and each quarter of its financial year; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) within 10 Brussels business days following a request in writing by a Bondholder (at any time, acting reasonably, but on no more than two occasions each calendar year),

a certificate in substantially the form set out in Schedule 5 (*Form of Officers' Certificate*) of the Bond Instrument and signed by at least one authorised signatory of the Issuer (being responsible accounting or financial officer or director) certifying:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the details of any Security Interest created over any assets of, the Issuer and/or any of its Subsidiaries, since the date of the last such certificate (or, in the case of the first such certificate, the Issue Date),

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) that the terms of any Financial Indebtedness incurred by the Issuer or any of its Subsidiaries since the date of the last such certificate (or, in the case of the first such certificate, the Issue Date) do not, expressly or impliedly, limit, impair or otherwise restrict the ability of the Issuer to at all times perform and comply with its payment, indemnity and/or any other obligations under these Conditions or the terms of any of the Bond Documents; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) that no Relevant Event has occurred and that no Event of Default or Potential Event of Default has occurred and is continuing since the date of the last such certificate (or, in the case of the first such certificate, the Issue Date) or if such an event has occurred, giving all relevant details of such event.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) For so long as any Bonds are outstanding, the Issuer shall publish as soon as the same become available, but in any event:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) within four calendar months after the end of each of its financial years, commencing with the financial year ended 31 December 2025, the Issuer's audited consolidated financial statements for such financial year, with accompanying notes and prepared in accordance with IFRS accounting principles generally accepted in Belgium consistently applied; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) within three calendar months after the end of each quarterly period for each of its financial years commencing with the three months ended 31 March 2026, the Issuer's unaudited consolidated financial statements for such period, with accompanying notes.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) For so long as any Bond remains outstanding:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the Issuer shall not, and the Issuer shall procure that its Subsidiaries will not, enter into any amalgamation, demerger, merger, consolidation or corporate reconstruction or reorganisation, except:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) in relation to any partnering and/or licensing transactions with third parties for the purposes of developing (including clinical trials), manufacturing,

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marketing or distributing its medical treatments, future products, technologies or intellectual property or otherwise; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) on terms approved by the Majority Bondholders;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the Issuer shall not, and the Issuer shall procure that its Subsidiaries will not, except on terms approved by the Majority Bondholders, enter into a single transaction or a series of transactions (whether related or not) and whether voluntary or involuntary to sell, lease, transfer or otherwise dispose of any asset, other than any sale, lease, transfer or other disposal which is:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) made by the Issuer or any of its Subsidiaries in the ordinary course of trading of the disposing entity;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) made by the Issuer or any of its Subsidiaries in relation to any partnering and/or licensing transactions with third parties, including but not limited to collaborations, joint ventures, or strategic alliances, for the purpose of developing (including clinical trials), manufacturing, marketing, or distributing its medical treatments, future products, technologies, or intellectual property. For the avoidance of doubt, such transactions may include, but are not limited to, the granting of and/or accepting licenses, sublicenses, or other rights to use the patents, trademarks, copyrights, trade secrets, know-how or other proprietary information;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(C) of assets (other than shares, businesses, real property or intellectual property) in exchange for other assets comparable or superior as to type, value and quality;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(D) of obsolete or redundant vehicles, plant and equipment for cash; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(E) the solvent liquidation or reorganisation of any Subsidiary of the Issuer so long as any payments or assets distributed as a result of such liquidation or reorganisation are distributed to the Issuer and/or its Subsidiaries;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) the Issuer shall, and the Issuer shall procure that its Subsidiaries will, comply with all laws and regulations to which they may be subject from time to time, if failure so to comply would impair the Issuer's ability to perform its obligations under the Bonds and the Bond Documents;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) the Issuer shall, and the Issuer shall procure that its Subsidiaries will, ensure that no substantial change is made to the general nature of the business of the Issuer and its Subsidiaries from that carried on as at the Issue Date,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) the Issuer shall, and the Issuer shall procure that its Subsidiaries shall, promptly:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) obtain, comply with and do all that is necessary to maintain in full force and effect; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) upon request by the Majority Bondholders, supply certified copies to the Bondholders of,

any Authorisation required under any law or regulation of its jurisdiction of incorporation to enable it to perform its obligations under the Bonds and the Bond

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Documents and to ensure the legality, validity, enforceability or admissibility in evidence in its jurisdiction of incorporation of the Bonds or any Bond Document;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) the Issuer shall not, and the Issuer shall procure that none of its Subsidiaries will, enter into any transaction with any affiliate(s), unless such transaction is on terms that are not materially less favourable to the Issuer or such Subsidiary, as applicable, than those that could be obtained at the time of such transaction in arm's-length dealings with a person that is not an affiliate;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) the Issuer shall not, and shall procure that its Subsidiaries shall not, at any time, create or otherwise cause or permit to exist or become effective (expressly or impliedly) any consensual encumbrance or restriction on the ability of the Issuer to at all times perform and comply with its payment, indemnity and/or any other obligations under these Conditions or the terms of any of the Bond Documents; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(viii) the Issuer shall not, and shall procure that its Subsidiaries shall not, amend, modify, vary any term of the EIB Facility, or enter into any new agreements, instruments or other arrangements with the European Investment Bank, in each case that could reasonably be expected to impair, restrict, prohibit or limit the Issuer's ability to perform its obligations under the Bonds and the Bond Documents (including, without limitation, its ability to make payments under the Bonds in cash).

**3.** **Definitions**

In these Conditions, unless otherwise provided:

"**€**" or "**EUR**" means the euro currency introduced at the start of the third stage of European economic and monetary union, and as defined in Article 2 of Council Regulation (EC) No 974/98 of 3 May 1998 on the introduction of the euro, as amended.

"**Advanced Amortised Payment Amount**" has the meaning provided in Condition 7.1(c)(i) (*Deferral and Advancement of Amortisation Payments*).

"**Advanced Amortisation Payment Date**" has the meaning provided in Condition 7.1(c)(i) (*Deferral and Advancement of Amortisation Payments*).

"**Additional Shares**" has the meaning provided in Condition 6.3 (*Retroactive Adjustments*).

"**affiliate**" (a) for the purposes of Condition 17 (*Beneficial Ownership of Shares*), has the meaning given to it in Rule 501(b) of Regulation D under the Securities Act, and (b) in all other cases, means a person that directly, or indirectly through one or more intermediaries, Controls or is Controlled by, or is under common Control with, the person specified.

"**Amortisation Conversion Right**" has the meaning provided in Condition 6.1 (Conversion Period and Conversion Price).

"**Amortisation Payment Date**" has the meaning provided in Condition 7.1(a) (*Scheduled Amortisation Payments*).

"**Amortised Payment Advancement**" has the meaning provided in Condition 7.1(c)(ii) (*Deferral and Advancement of Amortisation Payments*).

"**Amortised Payment Advancement Notice**" has the meaning provided in Condition 7.1(c)(ii) (*Deferral and Advancement of Amortisation Payments*).

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"**Amortised Payment Amount**" has the meaning provided in Condition 7.1(a) (*Scheduled Amortisation Payments*).

"**Amortised Payment Deferral**" has the meaning provided in Condition 7.1(c)(i) (*Deferral and Advancement of Amortisation Payments*).

"**Applicable Adjustment Record Date**" means, in respect of any of the events referred to in Conditions 6.2(a) (*Consolidation, reclassification, redesignation or subdivision*) to 6.2(i) (*Certain arrangements*), the record date in respect of any consolidation, reclassification, re-designation or sub-division as is mentioned in Condition 6.2(a) (*Consolidation, reclassification, redesignation or subdivision*) to 6.2(i) (*Certain arrangements*), or which is the record date or other due date for the establishment of entitlement for any such issue, distribution, grant or offer (as the case may be) as is mentioned in Condition 6.2(b) (*Capitalisation of profits or reserves*), 6.2(c) (*Dividends*), 6.2(d) (*Rights issues*), 6.2(e) (*Issue of Securities to Shareholders*) or 6.2(i) (*Certain arrangements*), or which is the date of the first public announcement of the terms of any such issue or grant as is mentioned in Condition 6.2(f) (*Issue of Shares at below Current Market Price*) and 6.2(g) (*Other issues*) or of the terms of any such modification as is mentioned in Condition 6.2(h) (*Modification of rights*).

"**Applicable Adjustment Reference Date**" means, in respect of any of the events referred to in Conditions 6.2(a) (*Consolidation, reclassification, redesignation or subdivision*) to 6.2(i) (*Certain arrangements*), (i) in the case of an adjustment pursuant to Conditions 6.2(a) (*Consolidation, reclassification, redesignation or subdivision*), 6.2(b) (*Capitalisation of profits or reserves*), 6.2(c) (*Dividends*), 6.2(d) (*Rights issues*), 6.2(e) (*Issue of Securities to Shareholders*) or 6.2(i) (*Certain arrangements*), the relevant Ex-Date of the relevant event in respect of which such adjustment is made and (ii) in the case of an adjustment pursuant to Conditions 6.2(f) (*Issue of Shares at below Current Market Price*), 6.2(g) (*Other issues*) or 6.2(h) (*Modification of rights*), the relevant date of the first public announcement as is mentioned in Conditions 6.2(f) (*Issue of Shares at below Current Market Price*), 6.2(g) (*Other issues*) or 6.2(h) (*Modification of rights*), as the case may be.

"**Attribution Parties**" means, in respect of a Bondholder, collectively, the following persons and entities:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) any investment vehicle, including, any funds, feeder funds or managed accounts, currently, or from time to time after the Issue Date, directly or indirectly managed or advised by the Bondholder's investment manager or any of its affiliates or principals;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) any direct or indirect affiliates of the Bondholder or any of the foregoing;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) any person acting or who could be deemed to be acting as a group together with the Bondholder or any of the foregoing; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) any other persons whose beneficial ownership of the Shares would or could be aggregated with the Bondholder's and the other Attribution Parties for purposes of Section 13(d) of the Exchange Act.

"**Authorisation**" means an authorisation, consent, approval, resolution, licence, exemption, filing, notarisation or registration.

"**Belgian/US Share Confirmation**" has the meaning given in Condition 9.9(e)(vii) (*Provisions relating to the Share Settlement Option*).

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"**Belgian Code on Companies and Associations**" means the Belgian Companies and Associations Code (*Wetboek van vennootschappen en verenigingen/Code des sociétés et des associations*), as amended.

"**Belgian Crossroads Bank for Enterprises"** means the Crossroads Bank for Enterprises (*Banque-Carrefour des Entreprises/Kruispuntbank van Ondernemingen*), a public institution established under Belgian law, which manages the central database of business entities registered in Belgium.

"**Belgian Civil Code**" means the Belgian Civil Code (*Burgerlijk Wetboek/Code civil*), as amended from time to time.

"**Belgian Share**" means any Share that is required pursuant to these Conditions to be issued or transferred and delivered in dematerialised form through the securities trading system operated by Euroclear Belgium on exercise of Conversion Rights or the Share Settlement Option.

"**Bloomberg Screen Observation Time**" means, in respect of any dealing day in respect of the Shares, other Securities, Spin-Off Securities, options, warrants, or other rights or assets, such time of observation as is determined by the Calculation Agent in its sole discretion, provided that such Bloomberg Screen Observation Time (i) may not occur prior to the Regular Closing Time (in respect of the Shares, or such other Securities, Spin-Off Securities options, warrants, or other rights or assets, as the case may be) on such dealing day, and (ii) may occur at any time after such dealing day, provided that where such Regular Closing Time occurs after 6 p.m. (Brussels time), such Bloomberg Screen Observation Time shall occur on the immediately following day (and no later than 1 p.m. (Brussels time) on such day) which is a Qualifying Business Day.

"**Bond Certificate**" has the meaning provided in the Bond Instrument.

"**Bond Conversion Right**" has the meaning provided in Condition 6.1 (Conversion Period and Conversion Price).

"**Bond Documents**" has the meaning provided in the Bond Instrument.

"**Bondholder**" and "**holder**" mean the person in whose name a Bond is registered in the Register (as defined in the Bond Instrument).

"**Bondholder Reserved Matter**" means an amendment or waiver of any term of the Bonds or the Bond Documents which has the effect of changing or which relates to:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) this definition of "Bondholder Reserved Matter" or the definition of "Majority Bondholders";

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) a modification of the date of payment (including any optional redemption pursuant to these Conditions) of any principal, interest, Cash Alternative Amount or other amount payable to a Bondholder under the Bonds or the Bond Documents;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) a variation in the amount or calculation of any payment of principal, interest, Cash Alternative Amount or other amount (including a number of Shares) payable or deliverable to a Bondholder under the Bonds or the Bond Documents;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) any modification or cancellation of the Conversion Rights or the rights of Bondholders to receive Shares and/or the Cash Alternative Amount on the exercise of Conversion Rights pursuant to these Conditions;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) any increase in the Conversion Price, other than in accordance with these Conditions;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) the right to receive Deliverable Shares following the exercise of a Share Settlement Option;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) any change in the governing law of the Bonds or the Bond Documents;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) a change in currency of payment of any amount under the Bonds or any Bond Document;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) a change to the Issuer as the issuing entity of the Bonds;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(j) a change to any provision which expressly requires the consent of Bondholders; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(k) any amendment to the rights of a Bondholder to assign or transfer its rights or obligations under the Bonds and/or the Bond Documents.

"**Bondholder Taxes**" has the meaning provided in Condition 6.9 (*Procedure for exercise of Conversion Rights*).

"**business day**" means, in relation to any place, a day (other than a Saturday or Sunday) on which commercial banks and foreign exchange markets are open for business in that place.

"**Cash Alternative Amount**" means, in respect of any exercise of Conversion Rights in respect of which the Issuer shall have made a Cash Alternative Election, an amount in EUR calculated by the Calculation Agent (and rounded to the nearest whole multiple of €0.01, with €0.005 rounded upwards) in accordance with the following formula and which shall be payable by the Issuer to a Bondholder in respect of the relevant Cash Settled Shares specified in the relevant Cash Alternative Election Notice:

---

| | | | |
|:---|:---|:---|:---|
| CAA = S x P | CAA = S x P | CAA = S x P | CAA = S x P |
| where: |  |  |  |
|  | CAA | &nbsp;&nbsp;= | the Cash Alternative Amount |
|  | S  | &nbsp;&nbsp;= | the Cash Settled Shares; and |
|  | P  | &nbsp;&nbsp;= | the Volume Weighted Average Price of a Share (translated if necessary into EUR at the Prevailing Rate) on the relevant Conversion Date (or, if the Conversion Date is not a dealing day, the immediately preceding dealing day). |

---

*Provided that*:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) if any Dividend or other entitlement in respect of the Shares is announced, (whether on or prior to or after the relevant Conversion Date) in circumstances where the record date or other due date for the establishment of entitlement in respect of such Dividend or other entitlement shall be on or after the relevant Registration Date (or, if there are no Physically Settled Shares in respect of such exercise of Conversion Rights, the relevant Conversion Date) and if the Volume Weighted Average Price on the Conversion Date (or, if the Conversion Date is not a dealing day, the immediately preceding dealing day) is based on a price ex- such Dividend or ex- such other entitlement, then such price shall be increased by an amount equal to the Fair Market Value of any such Dividend or other entitlement per Share as at the Ex-Date in respect of such Dividend or entitlement, determined by the Calculation Agent on a gross basis and disregarding any withholding or deduction required to be made for or on account of tax, and disregarding any associated tax credit, all as determined by the Calculation Agent;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) if any Retroactive Adjustment occurs in respect of the exercise of Conversion Rights in respect of which the Cash Alternative Amount is being determined, and if the Conversion Date (or, if the Conversion Date is not a dealing day, the immediately preceding dealing day) falls on or after the Applicable Adjustment Reference Date in respect of the event giving rise to such Retroactive Adjustment, the Volume Weighted Average Price on the Conversion Date (or, if the Conversion Date is not a dealing day, the immediately preceding dealing day) shall be multiplied by a fraction, (x) the numerator of which is the Conversion Price in effect immediately prior to the relevant adjustment to the Conversion Price becoming effective, and (y) the denominator of which is the Conversion Price so adjusted, all as determined by the Calculation Agent; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) if any doubt shall arise as to the calculation of the Cash Alternative Amount or if such amount cannot be determined as provided above, the Cash Alternative Amount shall be equal to such amount as is determined in such other manner as an Independent Adviser shall consider to be appropriate to give the intended result.

"**Cash Alternative Election**" has the meaning provided in Condition 6.10(a) (*Cash Alternative Election*).

"**Cash Alternative Election Date**" has the meaning provided in Condition 6.10(a) (*Cash Alternative Election*).

"**Cash Alternative Election Notice**" has the meaning provided in Condition 6.10(a) (*Cash Alternative Election*).

"**Cash Amortisation Price**" means:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) (in respect of any Amortised Payment Amount which is not an Advanced Amortised Payment Amount) 103 per cent. of the applicable Amortised Payment Amount; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) (in respect of any Advanced Amortised Payment Amount) the greater of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) 103 per cent. of such Advanced Amortised Payment Amount; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the product (rounded to the nearest whole multiple of €0.01, with €0.005 rounded upwards) of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) the quotient of (x) the Volume Weighted Average Price of the Shares (translated if necessary into EUR at the Prevailing Rate) on the dealing day immediately preceding the day on which the relevant Amortised Payment Advancement Notice is given (or deemed to be given pursuant to Condition 7.1(c)(ii)(B) (*Deferral and Advancement of Amortisation Payments*), and (y) the Relevant Share Settlement Price in respect of the relevant SSO Reference Date; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) such Advanced Amortised Payment Amount,

*provided that* if any doubt shall arise as to the calculation of the Cash Amortisation Price or if such amount cannot be determined as provided above, the Cash Amortisation Price shall be equal to such amount as is determined in such other manner as an Independent Adviser shall consider to be appropriate to give the intended result.

"**Cash Settled Shares**" means, in respect of the exercise of Conversion Rights by a Bondholder, such number of Shares (which shall be a whole number of Shares and shall not exceed the number

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of Reference Shares in respect of such exercise) as determined by the Issuer and notified to the relevant Bondholder in the relevant Cash Alternative Election Notice in accordance with Condition 6.10 (*Cash Alternative Election*).

"**Cash Settlement Ratio**" means, in respect of an exercise of Conversion Rights the subject of a Cash Alternative Election, such number as is equal to (a) the Cash Settled Shares in respect of such exercise of Conversion Rights divided by (b) the Reference Shares in respect of such exercise of Conversion Rights.

A "**Change of Control**" means the occurrence of an event or series of events whereby one or more persons, acting in concert, acquire Control over the Issuer.

"**Change of Control Conversion Right Amendment**" has the meaning provided in Condition 11(b)(vii) (*Undertakings*).

"**Change of Control Resolutions**" means, in the case of a Change of Control, one or more resolutions duly adopted at a general meeting of the Shareholders of the Issuer approving and confirming the provisions of Condition 6.2(j) and Condition 7.2 in accordance with Article 7:151 of the Belgian Companies and Associations Code.

"**Closing Price**" means, in respect of a Share or any other Security, Spin-Off Security, option, warrant or other right or asset, on any dealing day in respect thereof, the closing price on the Relevant Stock Exchange on such dealing day of a Share or, as the case may be, such other Security, Spin-Off Security, option, warrant or other right or asset, as published by or derived from Bloomberg page HP (or any successor page) (setting 'PR005 Last Price', or any other successor setting and using values not adjusted for any event occurring after such dealing day; and for the avoidance of doubt, all values will be determined with all adjustment settings on the DPDF Page, or any successor or similar setting, switched off) in respect of such Share, or, as the case may be, such other Security, Spin-Off Security, option, warrant or other right or asset (all as determined by the Calculation Agent as at the Bloomberg Screen Observation Time in respect of such dealing day) (and for the avoidance of doubt such Bloomberg page for the Shares as at the Issue Date is NYXH BB Equity HP), if available or, in any other case, such other source (if any) as shall be determined to be appropriate by an Independent Adviser on such dealing day, provided that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) if on any such dealing day (for the purpose of this definition, the "**Original Date**") such price is not available or cannot otherwise be determined as provided above, the Closing Price of a Share, such other Security, Spin-Off Security, option, warrant, or other right or asset, as the case may be, in respect of such dealing day shall be the Closing Price, determined by the Calculation Agent as provided above, on the immediately preceding dealing day in respect thereof on which the same can be so determined, provided however that if such immediately preceding dealing day falls prior to the fifth day before the Original Date, the Closing Price in respect of such dealing day shall be considered to be not capable of being determined pursuant to this proviso (a); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) if the Closing Price cannot be determined as aforesaid, the Closing Price of a Share, such other Security, Spin-Off Security, option, warrant, or other right or asset, as the case may be, shall be determined as at the Original Date by an Independent Adviser in such manner as it shall determine to be appropriate,

and the Closing Price determined as aforesaid on or as at any dealing day shall, if not in the Relevant Currency, be translated if necessary into the Relevant Currency at the Prevailing Rate on such dealing day.

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"**Concurrent Equity Raise**" means the primary placing of newly issued Shares pursuant to an equity private placement on the terms announced by the Issuer on 18 November 2025 (the "**Concurrent Equity Raise Pricing Date**").

"**Control**" means "control" within the meaning of Article 1:14 of the Belgian Companies and Associations Code and the terms "**Controlled**" and "**Controlling**" shall be construed accordingly.

"**Conversion Date**" has the meaning provided in Condition 6.9 (*Procedure for exercise of Conversion Rights*).

"**Conversion Notice**" means a notice (which shall be irrevocable) delivered by a Bondholder to the Issuer in or substantially in the form set out in Schedule 6 (*Form of Conversion Notice*) of the Bond Instrument.

"**Conversion Period**" has the meaning provided in Condition 6.1 (*Conversion Period and Conversion Price*).

"**Conversion Price**" has the meaning provided in Condition 6.1 (*Conversion Period and Conversion Price*).

"**Conversion Right**" has the meaning provided in Condition 6.1 (*Conversion Period and Conversion Price*).

"**Current Market Price**" means, in respect of a Share at a particular date, the arithmetic average of the daily Volume Weighted Average Price of a Share on each of the five consecutive dealing days ending on the dealing day immediately preceding such date, as determined by the Calculation Agent, *provided that*:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) for the purposes of determining the Current Market Price pursuant to Condition 6.2(d) (*Rights issues*) or 6.2(f) (*Issue of Shares at below Current Market Price*) in circumstances where the relevant event relates to an issue of Shares, if at any time during the said five dealing-day period (which may be on each of such five dealing days) the Volume Weighted Average Price shall have been based on a price ex-Dividend (or ex- any other entitlement) and/or during some other part of that period (which may be on each of such five dealing days) the Volume Weighted Average Price shall have been based on a price cum-Dividend (or cum- any other entitlement), in any such case which has been declared or announced, then:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) if the Shares to be so issued do not rank for the Dividend (or entitlement) in question, the Volume Weighted Average Price on the dates on which the Shares shall have been based on a price cum-Dividend (or cum- any other entitlement) shall for the purpose of this definition be deemed to be the amount thereof reduced by an amount equal to the Fair Market Value of any such Dividend or entitlement per Share as at the Ex-Date in respect of such Dividend or entitlement (or, where on each of the said five dealing days the Volume Weighted Average Price shall have been based on a price cum-Dividend (or cum-any other entitlement), as at the date of first public announcement of such Dividend or entitlement), in any such case, determined by the Calculation Agent on a gross basis and disregarding any withholding or deduction required to be made for or on account of tax, and disregarding any associated tax credit; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) if the Shares to be so issued do rank for the Dividend or entitlement in question, the Volume Weighted Average Price on the dates on which the Shares shall have been based on a price ex-Dividend (or ex- any other entitlement) shall for the

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purpose of this definition be deemed to be the amount thereof increased by an amount equal to the Fair Market Value of any such Dividend or entitlement per Share as at the Ex-Date in respect of such Dividend or entitlement, in any such case, determined by the Calculation Agent on a gross basis and disregarding any withholding or deduction required to be made for or on account of tax, and disregarding any associated tax credit;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) for the purpose of determining the Current Market Price of any Shares which may be comprised in a Scrip Dividend, if on any of the said five dealing days the Volume Weighted Average Price of the Shares shall have been based on a price cum all or part of such Scrip Dividend, the Volume Weighted Average Price of a Share on such dealing day or dealing days shall for the purposes of this definition be deemed to be the amount thereof reduced by an amount equal to the value (as determined in accordance with paragraph (a) of the definition of "**Dividend**") of such Scrip Dividend or part thereof; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) for any other purpose, if any day during the said five dealing-day period was the Ex-Date in relation to any Dividend (or any other entitlement) the Volume Weighted Average Prices that shall have been based on a price cum- such Dividend (or cum- such entitlement) shall for the purpose of this definition be deemed to be the amount thereof reduced by an amount equal to the Fair Market Value of any such Dividend or entitlement per Share as at the ExDate in respect of such Dividend or entitlement.

"**Daily Traded Value**" has the meaning provided in Condition 9.9(d) (*Annulment of Share Settlement Option*).

A "**De-Listing Event**" shall occur if:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the Shares at any time cease to be admitted to listing and trading on the Relevant Stock Exchange or the Relevant Stock Exchange announce that the Shares will cease to be admitted to listing and trading on such Relevant Stock Exchange, unless the Shares are already admitted to or are immediately (or substantially immediately) upon such cessation admitted to (or, in the case of such an announcement, are immediately (or substantially immediately) upon such announcement to be admitted to) listing and/or trading on another internationally recognised and regularly operating stock exchange; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) trading of the Shares on the Relevant Stock Exchange is suspended for a period of five consecutive Stock Exchange Dealing Days, provided that trading of the Shares shall not be considered to be suspended on any Stock Exchange Dealing Day on which a general suspension of trading on the Relevant Stock Exchange has occurred or where such suspension is in connection with a capital raise, merger, amalgamation or consolidation relating to the Issuer (and, in any such case, a De-Listing Event pursuant to this limb (b) shall be deemed to occur on the last day of such period of five consecutive Stock Exchange Dealing Days),

provided that following the occurrence of a De-Listing Event as provided above, no further DeListing Event may occur unless, in the case of limb (a) above, the Shares shall subsequently have been listed and admitted to trading and listing on another internationally recognised and regularly operating stock exchange or, in the case of limb (b) above, such suspension shall have ceased.

"**Deferred Amortised Payment Amount**" has the meaning provided in Condition 7.1(c)(i) (*Deferral and Advancement of Amortisation Payments*).

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"**dealing day**" means, in respect of the Shares, other Securities, Spin-Off Securities options, warrants, or other rights or assets, a day (other than a Saturday or a Sunday) on which the Relevant Stock Exchange in respect thereof is open for business and on which such Shares, other Securities, Spin-Off Securities options, warrants or other rights or assets (as the case may be) may be dealt in (other than a day on which the Relevant Stock Exchange is scheduled to or does close prior to its regular weekday closing time), provided that, unless otherwise specified or the context otherwise requires, references to "dealing day" shall be a dealing day in respect of the Shares.

"**Deliverable Shares**" has the meaning provided in Condition 9.9(c) (*Certain Definitions*).

"**Disruption Event**" means either or both of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) a material disruption to those payment or share registration and/or delivery systems or to those markets which are, in each case, required to operate in order for payments and/or share registration and/or delivery obligations to be made in connection with these Conditions; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the occurrence of any other event which results in a disruption (of a technical or systems-related nature) to the treasury, share registration and/or delivery or payments operations of the Issuer preventing it from performing its Share delivery obligations under these Conditions,

and which (in either such case) is not caused by, and is beyond the control of, the Issuer.

"**Dividend**" means any dividend or distribution to Shareholders (including a Spin-Off) whether of cash, assets or other property, and however described and whether payable out of a share premium account, profits, retained earnings or any other capital or revenue reserve or account, and including a distribution or payment to Shareholders upon or in connection with a reduction of capital (and for these purposes a distribution of assets includes without limitation an issue of Shares or other Securities credited as fully or partly paid up by way of capitalisation of profits or reserves), provided that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) where a Scrip Dividend is announced, then the Scrip Dividend in question shall be treated as a cash Dividend of an amount equal to the sum of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) in respect of the portion (if any) of the Scrip Dividend (which may be the whole of the Scrip Dividend) for which a Shareholder or Shareholders may make an election, the value of the option with the highest value, with the value of each option being equal to the value of the relevant property comprising such option as at the Scrip Dividend Valuation Date provided that, in the case of an option comprising more than one type of property, the value of such option shall be equal to the sum of the values of each individual type of property comprising such option, determined as provided below; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) in respect of the portion (if any) of the Scrip Dividend (which may be the whole of the Scrip Dividend) which is not subject to such election, the value of such portion as determined as provided below,

and where the "**value**" of any property in or comprising of a Scrip Dividend shall be determined as follows:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(x) in the case of Shares comprised in such Scrip Dividend, the Current Market Price of such Shares as at the Scrip Dividend Valuation Date;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(y) in the case of cash comprising in such Scrip Dividend, the Fair Market Value of such cash as at the Scrip Dividend Valuation Date; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(z) in the case of any other property or assets comprised in such Scrip Dividend, the Fair Market Value of such other property or assets as at the Scrip Dividend Valuation Date;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) any issue of Shares falling within Condition 6.2(a) (*Consolidation, reclassification, redesignation or subdivision*) or Condition 6.2(b) (*Capitalisation of profits or reserves*) shall be disregarded;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) a purchase or redemption or buy back of any Shares of the Issuer by or on behalf of the Issuer or any of its Subsidiaries shall not constitute a Dividend unless, in the case of a purchase or redemption or buy back of Shares by or on behalf of the Issuer or any of its Subsidiaries, the weighted average price per Share (before expenses) on any day (a "**Specified Share Day**") in respect of such purchases or redemptions or buy backs (translated, if not in the Relevant Currency, into the Relevant Currency at the Prevailing Rate on such day) exceeds by more than 5 per cent. the Current Market Price of a Share:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) on the Specified Share Day; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) where an announcement (excluding, for the avoidance of doubt for these purposes, any general authority for such purchases, redemptions or buy backs approved by a general meeting of Shareholders or any notice convening such a meeting of Shareholders) has been made of the intention to purchase, redeem or buy back Shares at some future date at a specified price or where a tender offer is made, on the date of such announcement or, as the case may be, on the date of first public announcement of such tender offer (and regardless of whether or not a price per Share, a minimum price per Share or a price range or a formula for the determination thereof is or is not announced at such time),

in which case such purchase, redemption or buy back shall be deemed to constitute a Dividend in the Relevant Currency in an amount equal to the amount by which the aggregate price paid (before expenses) in respect of such Shares purchased, redeemed or bought back by or on behalf of the Issuer or, as the case may be, any of its Subsidiaries (translated where appropriate into the Relevant Currency as provided above) exceeds the product of (i) 105 per cent. of such Current Market Price and (ii) the number of Shares so purchased, redeemed or bought back;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) if the Issuer or any of its Subsidiaries (or any person on its or their behalf) shall purchase, redeem or buy back any depositary or other receipts or certificates representing Shares, the provisions of paragraph (c) above shall be applied in respect thereof in such manner and with such modifications (if any) as shall be determined by an Independent Adviser;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) where a dividend or distribution is paid or made to Shareholders pursuant to any plan or arrangement implemented by the Issuer for the purpose of enabling Shareholders to elect, or which may require Shareholders, to receive dividends or distributions in respect of the Shares held by them from a person other than (or in addition to) the Issuer, such dividend or distribution shall for the purposes of these Conditions be treated as a dividend or distribution made or paid to Shareholders by the Issuer, and the foregoing provisions of this definition and the provisions of these Conditions shall be construed accordingly;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) where a Dividend in cash is declared which provides for payment by the Issuer in the Relevant Currency (or, in the case of a Scrip Dividend, an amount in cash is or may be paid in the Relevant Currency, whether at the option of Shareholders or otherwise), it shall be treated as a Dividend in cash (or, in the case of a Scrip Dividend, an amount in cash) in such Relevant Currency, and in any other case it shall be treated as a Dividend in cash (or, in the case of a Scrip Dividend an amount in cash) in the currency in which it is payable by the Issuer; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) a dividend or distribution that is a Spin-Off shall be deemed to be a Dividend paid or made by the Issuer,

and any such determination shall be made by the Calculation Agent or, where specifically provided, an Independent Adviser and, in either such case, on a gross basis and disregarding any withholding or deduction required to be made for or on account of tax, and disregarding any associated tax credit.

"**DTC**" means The Depository Trust Company, a limited purpose trust company organised under the laws of the State of New York, and its successors and assigns.

"**Early Redemption Amount**" means in respect of any Bond, the sum of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the Make-Whole Premium; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) an amount equal to the greater of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) 120 per cent. of the principal amount of such Bond outstanding on the relevant Early Redemption Amount Date; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the relevant Parity Value of a Bond,

where for the purposes of this definition, "**Early Redemption Amount Date**" means (1) in the case of a redemption pursuant to Condition 7.2 (*Redemption at the Option of Bondholders (Relevant Event*)), the Relevant Event Put Date, or (2) in the case of an amount becoming due pursuant to Condition 10 (*Events of Default*), the date of the giving of notice by the holders of at least one-quarter in principal amount of the Bonds then outstanding in accordance with the first paragraph of Condition 10 (*Events of Default*);

"**EIB Facility**" means the €37,500,000 facility agreement dated 3 July 2024 entered into between the European Investment Bank and the Issuer, as amended from time to time.

"**Enterprise Court**" means the Belgian court (Ondernemingsrechtbank/Tribunal de l'entreprise) established under Belgian law, which has jurisdiction over disputes relating to enterprises, commercial matters, and insolvency proceedings in Belgium.

"**Equity-Linked Rights**" has the meaning provided in Condition 6.4 (*Conversion Price Reset*).

"**Equity Raise**" has the meaning provided in Condition 6.4 (*Conversion Price Reset*).

"**equity shares**" means (other than for the purposes of Condition 6.2(c)) (*Dividends*), in relation to any entity, its total issued shares excluding any shares which, neither as respects dividends nor as respects capital, carries any right to participate beyond a specific amount in a distribution.

"**Euroclear Belgium**" means Caisse Interprofessionnelle de Dépôts et de Virements de Titres SA/Interprofessionnele Effectendepositen Girokas NV (C.I.K.) (commercial name Euroclear

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Belgium), enterprise number 0403 206 432 (Register of Legal Entities for Brussels), or any entity replacing the same as a central securities depository.

"**Euronext Brussels**" means the EEA Regulated Market of Euronext Brussels.

"**Event of Default**" has the meaning provided in Condition 10 (*Events of Default*).

"**Ex-Date**" means, in relation to any Dividend (including without limitation any Spin-Off), capitalisation, redesignation, reclassification, sub-division, consolidation, issue, grant, offer or other entitlement, unless otherwise defined herein, the first dealing day for the Shares on which the Shares are traded ex- the relevant Dividend, capitalisation, redesignation, reclassification, sub-division, consolidation, issue, grant, offer or other entitlement on the Relevant Stock Exchange (or, in the case of a Dividend which is a purchase, redemption or buy back of Shares (or, as the case may be, any depositary or other receipts or certificates representing Shares) pursuant to paragraph (c) (or, as the case may be, paragraph (d)) of the definition of "Dividend", the date on which such purchase, redemption or buy back is made), and provided that, for the avoidance of doubt, the Ex-Date in respect of a Scrip Dividend shall be deemed to be the Ex-Date in respect of the relevant Dividend or capitalisation as referred to in the definition of "Scrip Dividend".

"**Excess Shares**" has the meaning provided in Condition 17(e) (*Beneficial Ownership of Shares*).

"**Exchange Act**" means the U.S. Securities Exchange Act of 1934, as amended.

"**Excluded Instrument**" means any of the following:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the 1,400,000 subscription rights (*inschrijvingsrechten / droits de souscription*) issued by the Issuer on 8 September 2021 pursuant to the 2021 warrants plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the 700,000 subscription rights (*inschrijvingsrechten / droits de souscription*) issued by the Issuer on 28 December 2022 pursuant to the 2022 warrants plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) the 1,000,000 subscription rights (*inschrijvingsrechten / droits de souscription*) issued by the Issuer on 31 July 2024 pursuant to the 2024 warrants plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) the 805,000 subscription rights (*inschrijvingsrechten / droits de souscription*) issued by the Issuer on 30 January 2025 pursuant to the 2025 warrants plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) the 760,000 subscription rights (*inschrijvingsrechten / droits de souscription*) issued by the Issuer on 13 October 2025 pursuant to the 2025-2 warrants plan; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) the subscription rights (*inschrijvingsrechten / droits de souscription*), Shares, or restricted stock units to be issued or granted to directors of personnel of the Issuer (or its affiliates) from time to time in accordance with the remuneration policy of the Issuer, as amended; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) any subscription rights (*inschrijvingsrechten / droits de souscription*) that may be issued from time to time under any other personnel incentive plan,

*provided that,* on any date, (x) the Excluded Instruments, taken together, shall not entitle the beneficiaries thereof the right to subscribe for, acquire, or otherwise receive Shares in an aggregate number exceeding 10.0 per cent. of the Issuer's issued share capital (it being understood that any such subscription rights (*inschrijvingsrechten / droits de souscription*), Shares or restricted stock units issued in excess of the foregoing limitation shall not constitute an Excluded Instrument), and (y) in the case of paragraphs (g) and (h), the issuance of such subscription rights (*inschrijvingsrechten / droits de souscription*), Shares or restricted stock units are issued pursuant

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

to any remuneration policy or other personnel incentive plan that is duly approved by the Issuer's board of directors and (if applicable) its shareholders. Any reference in these Conditions to "**Excluded Instruments**" means all of them.

"**Fair Market Value**" means, on any date (the "**FMV Date**"):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) in the case of a cash Dividend, the amount of such cash Dividend, as determined by the Calculation Agent;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) in the case of any other cash amount, the amount of such cash, as determined by the Calculation Agent;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) in the case of Securities (including Shares), Spin-Off Securities, options, warrants or other rights or assets that are publicly traded on a Relevant Stock Exchange of adequate liquidity (as determined by the Calculation Agent or an Independent Adviser), the arithmetic mean of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) in the case of Shares or (to the extent constituting equity shares) other Securities or Spin-Off Securities, for which a daily Volume Weighted Average Price (disregarding for this purpose proviso (ii) to the definition thereof) can be determined, such daily Volume Weighted Average Price of the Shares or such other Securities or Spin-Off Securities; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) in any other case, the Closing Price of such Securities, Spin-Off Securities, options, warrants or other rights or assets,

in the case of both (a) and (b) during the period of five dealing days on the Relevant Stock Exchange for such Securities, Spin-Off Securities, options, warrants or other rights or assets commencing on such FMV Date (or, if later, the date (the "**Adjusted FMV Date**") which falls on the first such dealing day on which such Securities, Spin-Off Securities, options, warrants or other rights or assets are publicly traded, provided that where such Adjusted FMV Date falls after the fifth day following the FMV Date, the Fair Market Value of such Securities, Spin-Off Securities, options, warrants or other rights or assets shall instead be determined pursuant to paragraph (d) below, and no such Adjusted FMV Date shall be deemed to apply) or such shorter period as such Securities, Spin-Off Securities, options, warrants or other rights or assets are publicly traded, all as determined by the Calculation Agent;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) in the case of Securities, Spin-Off Securities, options, warrants or other rights or assets that are not publicly traded on a Relevant Stock Exchange of adequate liquidity (as aforesaid) or where otherwise provided in paragraph (c) above to be determined pursuant to this paragraph (d), an amount equal to the fair market value of such Securities, Spin-Off Securities, options, warrants or other rights or assets as determined by an Independent Adviser, on the basis of a commonly accepted market valuation method and taking account of such factors as it considers appropriate, including the market price per Share, the dividend yield of a Share, the volatility of such market price, prevailing interest rates and the terms of such Securities, Spin-Off Securities, options, warrants or other rights or assets, and including as to the expiry date and exercise price or the like (if any) thereof.

Such amounts shall (if not expressed in the Relevant Currency on the FMV Date (or, as the case may be, the Adjusted FMV Date)) be translated if necessary into the Relevant Currency at the Prevailing Rate on the FMV Date (or, as the case may be, the Adjusted FMV Date), all as determined by the Calculation Agent.

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

In addition, in the case of (a) and (b) above, the Fair Market Value shall be determined on a gross basis and disregarding any withholding or deduction required to be made for or on account of tax, and disregarding any associated tax credit.

"**Final Maturity Date**" means, at any time, the Original Final Maturity Date, and/or, following any Amortised Payment Advancement in accordance with Condition 7.1(c)(ii) (*Deferral and Advancement of Amortisation Payments*)), such earlier date on which, as at such time, the Bonds are scheduled to be redeemed in full in accordance with Condition 7.1(c)(ii) (*Deferral and Advancement of Amortisation Payments*).

"**Financial Indebtedness**" means any indebtedness of any person for or in respect of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) moneys borrowed;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) amounts raised by acceptance under any acceptance credit facility;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) amounts raised pursuant to any note purchase facility or the issue of bonds, notes, debentures, loan stock or similar instruments (including any such instruments which by their terms carry (directly or indirectly) rights of conversion into, or exchange or subscription for, or the right to otherwise acquire, any shares in the capital of the Issuer or any of its Subsidiaries);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) the amount of any liability in respect of any finance leases that is incurred in the ordinary course of the Issuer or a Subsidiary's business (as the case may be);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) the amount of any liability in respect of any purchase price for assets or services the payment of which is deferred primarily as a means of raising finance or financing the acquisition of the relevant asset or service;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) amounts raised under any other transaction (including any forward sale or purchase agreement and the sale of receivables or other assets on a "with recourse" basis) having the commercial effect of a borrowing;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) any derivative transaction entered into in connection with protection against or benefit from fluctuation in any rate or price (and, when calculating the value of any derivative transaction, only the mark-to-market value shall be taken into account);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) any counter-indemnity obligation in respect of any guarantee, indemnity, bond, standby or documentary letter of credit or any other instrument issued by a bank or financial institution; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) (without double counting) the amount of any liability in respect of any guarantee or indemnity for any of the items referred to in paragraphs (a) to (h) above.

"**Financial Indebtedness Guarantee**" means in relation to any Financial Indebtedness of any person, any obligation of another person to pay such indebtedness including (without limitation):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) any obligation to purchase such indebtedness;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) any obligation to lend money, to purchase or subscribe shares or other securities or to purchase assets or services in order to provide funds for the payment of such indebtedness;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) any indemnity against the consequences of a default in the payment of such indebtedness; and

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) any other agreement to be responsible for repayment of such indebtedness.

"**Free Float**" means all issued and outstanding Shares less (i) the aggregate of those Shares held by any person (other than a collective investment scheme, mutual fund, pension fund or other investment trust, in each case which is traded on a regulated market) holding five per cent. or more of the issued and outstanding Shares; (ii) the aggregate of those Shares held by any person or persons who have entered into shareholders' agreements or lock-up agreements concerning the Shares with a duration of more than six months; and (iii) any Shares held by or on behalf of the Issuer or any related party or affiliate.

A "**Free Float Event**" shall be deemed to have occurred if the Free Float of the Issuer is less than 10 per cent. of the issued and outstanding Shares on each Qualifying Business Day comprised in any period of 10 consecutive Qualifying Business Days (and in any such case the Free Float Event shall be deemed to occur on the last Qualifying Business Day of such period), *provided that* following the occurrence of any Free Float Event as provided above, no further Free Float Event may occur unless the Free Float of the Issuer shall subsequently have been at least 10 per cent. of the issued and outstanding Shares for a period of 10 consecutive Qualifying Business Days commencing at any time after the Relevant Event Put Date in respect of the immediately preceding Free Float Event.

"**Further Bonds**" means further bonds either having the same terms and conditions in all respects as the outstanding Bonds or having the same terms and conditions in all respects as the outstanding Bonds in all respects except for the first payment of interest on them and the first date on which Conversion Rights may be exercised and so that such further issue shall be consolidated and form a single series with the outstanding Bonds, and in each case which shall be issued only in accordance with Condition 17 (*Beneficial Ownership of Shares*).

"**IFRS**" means International Financial Reporting Standards issued by the International Accounting Standards Board (IASB) and interpretations issued by the International Reporting Interpretations Committee of the IASB (as amended, supplemented or re-issued from time to time).

"**Independent Adviser**" means an independent adviser with appropriate expertise, which may be the Calculation Agent appointed by the Issuer at its own expense and (other than where the initial Calculation Agent is appointed) approved in writing by the Majority Bondholders (acting reasonably) or, if the Issuer fails to make such appointment and such failure continues for a period of 14 days, as may be appointed by the Majority Bondholders (at the expense of the Issuer, and without liability for so doing) following notification to the Issuer, which appointment shall be deemed to be made by the Issuer.

"**Initial Conversion Price**" has the meaning provided in Condition 6.1 (*Conversion Period and Conversion Price*).

"**Interest Payment Date**" has the meaning provided in Condition 5.1(a) (*Interest Rate*).

"**Interest Period**" has the meaning provided in Condition 5.1(a) (*Interest Rate*).

"**Issue Date**" means 18 December 2025.

"**Longstop Date**" means the date of the annual shareholders' meeting of the Issuer resolving on the Issuer's financial statements as of and for the year ending 31 December 2025.

"**Majority Bondholders**" means, at any time, holders of more than 50 per cent. of the principal amount of the Bonds outstanding.

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

"**Make-Whole Premium**" means the (undiscounted) sum of all remaining scheduled interest payments due on the Bonds falling on or after the Early Redemption Amount Date, as calculated by the Calculation Agent.

"**Maximum Percentage**" has the meaning provided in Condition 17(a) (*Beneficial Ownership of Shares*).

"**Minimum PMP**" has the meaning provided in Condition 9.9(d) (*Annulment of Share Settlement Option*).

"**Offer Period**" has the meaning provided in Condition 9.9(c) (*Certain Definitions*).

"**Original Final Maturity Date**" means 18 November 2028, being the date falling on the three-year anniversary of the Concurrent Equity Raise Pricing Date.

"**outstanding**" means, in relation to the Bonds, all Bonds issued except (a) those which have been redeemed in accordance with these Conditions, (b) those in respect of which Conversion Rights have been exercised and the Issuer's obligations to issue and/or deliver Shares (and/or, in the case of a Cash Alternative Election, the Issuer's obligation to pay the Cash Alternative Amount) have been duly performed, (c) those in respect of which the date for redemption has occurred and the redemption moneys (including all interest accrued on such Bonds to the date for such redemption and any interest payable under Condition 5 (*Interest*) after such date) have been duly paid to the relevant Bondholder and for any obligations to issue or deliver Shares have been performed, and (d) those which have been redeemed and cancelled as provided in Condition 7 (*Redemption of Bonds*); *provided that* for the purposes of (1) ascertaining the right to vote on any voting matters pursuant to Condition 15 (*Amendment and Waiver*), (2) the determination of how many and which Bonds are outstanding for the purposes of Conditions 10 (*Events of Default*) and 15 (*Amendment and Waiver*), and (3) the exercise of any discretion, power or authority which each Bondholder is required, expressly or impliedly, to exercise, those Bonds which are beneficially held by or on behalf of the Issuer or any of its Subsidiaries or any of their respective affiliates and not cancelled shall (unless no longer so held) be deemed not to remain outstanding.

"**Parity Value**" of a Bond means the product (rounded to the nearest whole multiple of €0.01 (with €0.005 being rounded upwards)) of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) such number of Shares per Bond as would have been required to be issued or transferred and delivered in respect of such Bond had Conversion Rights been exercised in respect thereof, assuming for this purpose that the Conversion Date relating to such exercise of Conversion Rights is the Early Redemption Amount Date; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the arithmetic mean of the Volume Weighted Average Price of a Share (translated if necessary into EUR at the Prevailing Rate) on each dealing day comprised in the period of five consecutive dealing days ending on (and including) the second dealing day preceding the Early Redemption Amount Date,

in each case, all as determined by the Calculation Agent, *provided that* if (A) such period of five consecutive dealing days as aforesaid is not comprised in the period of 10 consecutive Brussels business days ending on (and including) the second Brussels business day immediately preceding the Early Redemption Amount Date, as the case may be, or (B**)** any doubt shall arise as to the calculation of the Parity Value or if such amount cannot be determined as provided above, in each case the Parity Value shall be equal to such amount as is determined in such other manner as an Independent Adviser shall consider to be appropriate to give the intended result.

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

"**Payment Details**" means, with respect to each Bondholder, the instructions provided by it to the Issuer (with a copy to the Calculation Agent) for the payment to the Bondholder of EUR cash payments and issue or transfer and delivery to the Bondholder of Shares (and which shall, for so long as the Shares are held through Euroclear Belgium or DTC, include Euroclear Belgium or DTC (as the case may be) account details), and which may be updated by a Bondholder at any time by giving notice to the Issuer in accordance with Condition 16 (*Notices*).

a "**person**" includes any individual, firm, company, corporation, government, state or agency of a state or any association, trust, joint venture, consortium, partnership or other entity (whether or not having separate legal personality).

"**Physically Settled Shares**" means, in respect of any exercise of Conversion Rights, (i) the Reference Shares or (ii) where such exercise is the subject of a Cash Alternative Election, such number of Shares (which may be equal to zero) as is equal to the Reference Shares minus the Cash Settled Shares.

"**Placing Price**" has the meaning provided in Condition 6.4 (*Conversion Price Reset*).

"**Placing Proceeds**" has the meaning provided in Condition 6.4 (*Conversion Price Reset*).

"**Potential Event of Default**" means an event or circumstance which would, with the giving of notice, lapse of time, issue of a certificate and/or fulfilment of any other requirement provided for in Condition 10 (*Events of Default*), become an Event of Default.

"**Prevailing Market Price**" has the meaning provided in Condition 9.9(d) (*Annulment of Share Settlement Option*).

"**Prevailing Rate**" means, in respect of any pair of currencies on any day, the spot mid-rate of exchange between the relevant currencies prevailing as at 4.00 p.m. (London time) on that date (for the purpose of this definition, the "**Original Date**") as appearing on or derived from Bloomberg page BFIX (or any successor page) in respect of such pair of currencies, or, if such a rate cannot be so determined, the rate prevailing as at 4.00 p.m. (London time) on the immediately preceding day on which such rate can be so determined, provided that if such immediately preceding day falls earlier than the fifth day prior to the Original Date or if such rate cannot be so determined (all as determined by the Calculation Agent), the Prevailing Rate in respect of the Original Date shall be the rate determined in such other manner as an Independent Adviser shall consider appropriate.

"**Put SSO Reference Date**" means, for the purpose of Condition 7.2 (*Redemption at the Option of Bondholders (Relevant Event)*), Condition 7.3 (Redemption if the Change of Control Resolutions are not passed) or Condition 10 (*Events of Default*), the dealing day immediately preceding the first date on which the relevant Early Redemption Amount is capable of being determined in accordance with these Conditions.

"**Qualifying Business Day**" means each of (a) a Brussels business day, and (b) a New York business day.

"**Qualifying Equity Raise**" has the meaning provided in Condition 6.4 (*Conversion Price Reset*).

"**Qualifying Stock Exchange Day**" means any day which appears as a trading day (other than a day on which such trading is scheduled to close prior to its regular weekday closing time) on each of:

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Bloomberg page CDR using the calendar setting for the Relevant Stock Exchange in respect of the Shares (such calendar setting being as at the Issue Date, for the avoidance of doubt, "BU" ("Euronext Brussels") (or any successor page or setting)); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) (if the Shares are listed and admitted to trading on any of the US Markets) Bloomberg page CDR using the calendar "EX" ("US exchanges") (or any successor page or setting).

"**Rate of Interest**" has the meaning provided in Condition 5.1(a) (*Interest Rate*).

"**Record Date**" has the meaning provided in Condition 9.3 (*Record Date*).

"**Reference Date**" means, in relation to a Retroactive Adjustment, the date as of which the relevant Retroactive Adjustment takes effect or, in any such case, if that is not a dealing day, the next following dealing day.

"**Reference Lowest Daily Market Price**" has the meaning provided in Condition 9.9(c) (*Certain Definitions*).

"**Reference Shares**" means, in respect of the exercise of Conversion Rights by a Bondholder, the number of Shares (rounded down, if necessary, to the nearest whole number) determined by the Calculation Agent by dividing the principal amount of the Bonds (or, as the case may be, the aggregate principal amount of the Upcoming Amortised Payment Amount(s)) which are the subject of the relevant exercise of Conversion Rights by the Conversion Price in effect on the relevant Conversion Date.

"**Registration Date**" has the meaning provided in Condition 6.11 (*Ranking and entitlement*).

"**Regular Amortisation Period**" means each period beginning on (and including) a Scheduled Amortisation Payment Date and ending on (but excluding) the next succeeding Scheduled Amortisation Payment Date.

"**Regular Closing Time**" means, in respect of the Shares, or other Securities, Spin-Off Securities, options, warrants, or other rights or assets, the regular weekday time at which the main trading session is scheduled to end (or, if later, such regular weekday time at which the closing price or final fixing price in respect of such main trading session is scheduled to be published) for the Shares, or such other Securities, Spin-Off Securities options, warrants, or other rights or assets on the Relevant Stock Exchange in respect thereof (whether or not on any dealing day such main trading session is scheduled to end or ends (or, as the case may be, such closing price or final fixing price as aforesaid is scheduled to be published or is published) prior to such regular weekday time as aforesaid. For the avoidance of doubt, as at the Issue Date, the Regular Closing Time in respect of the Shares and the Relevant Stock Exchange in respect thereof is 5:35 p.m. (Brussels time).

"**Relevant Currency**" means, at any time, the currency in which the Shares are quoted or dealt in at such time on the Relevant Stock Exchange in respect thereof.

"**Relevant Date**" means, in respect of any Bond, whichever is the later of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the date on which payment in respect of it first becomes due; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) if any amount payable is improperly withheld or refused, the date on which payment in full of the amount outstanding is made to Bondholders.

A "**Relevant Event**" shall occur if a Change of Control, a De-Listing Event or a Free Float Event occurs.

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

"**Relevant Event Conversion Price**" has the meaning provided in Condition 6.2(j) (*Relevant Event*).

"**Relevant Event Notice**" has the meaning provided in Condition 6.8 (*Relevant Event*).

"**Relevant Event Period**" means the period commencing on the date on which a Relevant Event occurs and ending five Brussels business days following such date or, if later, (unless such extension is waived by the Majority Bondholders) five Brussels business days following the date on which the Relevant Event Notice is given to Bondholders as required by Condition 7.2 (*Redemption at the Option of Bondholders (Relevant Event*)).

"**Relevant Event Put Date**" has the meaning provided in Condition 7.2 (*Redemption at the Option of Bondholders (Relevant Event*)).

"**Relevant Stock Exchange**" means:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) in respect of the Shares, Euronext Brussels or, if the Shares cease to be listed and admitted on Euronext Brussels (or any other stock exchange or securities market which is, as a result of the operation of this limb (a), the then prevailing Relevant Stock Exchange in respect of the Shares), such other principal stock exchange or securities market on which such Shares are (at the time of such cessation) listed and admitted to trading, if applicable; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) in respect of any Securities (other than Shares), Spin-Off Securities, options, warrants or other rights or assets, the principal stock exchange or securities market on which such Securities, Spin-Off Securities, options, warrants or other rights or assets are then listed and admitted to trading,

where "**principal stock exchange or securities market**" shall mean the stock exchange or securities market on which such Shares, such other Securities, Spin-Off Securities, options, warrants or other rights or assets are listed and admitted to trading, provided that if such Shares, such other Securities, Spin-Off Securities, options, warrants or other rights or assets are listed and admitted to trading on more than one stock exchange or securities market at the relevant time, then "**principal stock exchange or securities market**" shall mean that stock exchange or securities market on which such Shares, such other Securities, Spin-Off Securities, options, warrants or other rights or assets are then listed and admitted to trading as determined by the Calculation Agent (if the Calculation Agent determines that it is able to make such determination in its capacity as Calculation Agent) or (in any other case) by an Independent Adviser by reference to the stock exchange or securities market with the then prevailing highest 2-month average daily trading volume (as determined by reference to the Daily Traded Value) in respect of such Shares, such other Securities, Spin-Off Securities, options, warrants or other rights or assets.

"**Reported Outstanding Share Number**" has the meaning provided in Condition 17(c) (*Beneficial Ownership of Shares*).

"**Reporting Company**" means a company that is required to file reports periodically with the U.S. Securities and Exchange Commission under section 12, 13 or 15(d) of the Exchange Act.

"**Restricted Information**" means any information that is or may be material non-public and price-sensitive or is insider information within the meaning of applicable insider dealing or market abuse law (including Regulation 596/2014/EU).

A "**Retroactive Adjustment**" shall occur in respect of any exercise of Conversion Rights if (i) the Registration Date (or, if there are no Physically Settled Shares in respect of such exercise of Conversion Rights, the Conversion Date) in respect of such exercise shall be after the Applicable

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

Adjustment Record Date in respect of any event giving rise to an adjustment to the Conversion Price pursuant to Condition 6.2 (*Adjustment of Conversion Price*) and (ii) the Conversion Date in respect of such exercise shall be before such adjustment becomes effective under Condition 6.2 (*Adjustment of Conversion Price*).

"**Second Tranche Bonds**" means the amortising senior convertible bonds which may be issued by the Issuer in an aggregate principal amount not exceeding €22,500,000 between 18 July 2026 and 18 August 2026, subject to and in accordance with the terms of the Subscription Agreement.

"**Securities Act**" means the U.S. Securities Act of 1933, as amended.

"**Security Interest**" means a mortgage, charge, pledge, lien or other security interest securing any obligation of any person or any other agreement or arrangement having a similar effect.

"**Scheduled Amortisation Payment Date**" has the meaning provided in Condition 7.1(a) (*Scheduled Amortisation Payments*).

"**Scheduled Delivery Date**" has the meaning provided in Condition 6.9 (*Procedure for exercise of Conversion Rights*).

"**Scheduled SSO Delivery Date**" has the meaning provided in Condition 9.9(b) (*Share Settlement*).

"**Scrip Dividend**" means:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) a Dividend in cash which is to be satisfied, or a Dividend in cash which may at the election of a Shareholder or Shareholders be satisfied, in whole or in part, by the issue or delivery of Shares and/or other property or assets; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) an issue of Shares or other property or assets by way of a capitalisation of profits or reserves (including any share premium account or capital redemption reserve, and whether described as a scrip or share dividend or distribution or otherwise) which is to be satisfied, or which may at the election of a Shareholder or Shareholders be satisfied, in whole or in part, by the payment of cash.

"**Scrip Dividend Valuation Date**" means:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) in respect of any portion of a Scrip Dividend for which a Shareholder or Shareholders may make an election, the later of (i) the Ex-Date in relation to the relevant dividend or capitalisation, (ii) the last day on which the relevant election can be made by such Shareholder or Shareholders, and (iii) the date on which the number of Shares, amount of cash, or amount of other property or assets, as the case may be, which may be issued or delivered is publicly announced; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) in respect of any portion of a Scrip Dividend which is not subject to such election, the later of (i) the Ex-Date in relation to the relevant dividend or capitalisation and (ii) the date on which the number of Shares, amount of cash or amount of such other property or assets, as the case may be, to be issued and delivered is publicly announced.

"**Securities**" means any securities including, without limitation, Shares and any other shares of the Issuer, and options, warrants or other rights to subscribe for or purchase or acquire Shares or any other shares of the Issuer.

"**Share Average DTV**" has the meaning provided in Condition 9.9(a) (*Exercise of Share Settlement Option*).

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"**Share Settlement**" has the meaning provided in Condition 9.9(b) (*Share Settlement*).

A "**Share Settlement Free Float Event**" shall be deemed to have occurred on any Qualifying Business Day in the Share Settlement Liquidity Period (the "**Relevant Qualifying Business Day**") if the Free Float of the Issuer is less than 10 per cent. of the issued and outstanding Shares on each Qualifying Business Day comprised in the period of 10 consecutive Qualifying Business Days ending on (and including) such Relevant Qualifying Business Day.

"**Share Settlement Liquidity Event**" has the meaning provided in Condition 9.9(a) (*Exercise of Share Settlement Option*).

"**Share Settlement Liquidity Period**" has the meaning provided in Condition 9.9(a) (*Exercise of Share Settlement Option*).

"**Shareholders**" means the holders of Shares.

"**Shares**" means fully paid ordinary shares in the capital of the Issuer, with (as at the Issue Date) no nominal value and ISIN BE0974358906 (and each, a "**Share**").

"**Specified Date**" has the meaning provided in Conditions 6.2(f) (*Issue of Shares at below Current Market Price*), 6.2(g) (*Other issues*) and 6.2(h) (*Modification of rights*).

"**Specified Taxes**" has the meaning provided in Condition 6.9 (*Procedure for exercise of Conversion Rights*).

"**Spin-Off**" means:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) a distribution of Spin-Off Securities by the Issuer to Shareholders as a class; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) any issue, transfer or delivery of any property or assets (including cash or shares or other securities of or in or issued or allotted) by any entity (other than the Issuer) to Shareholders as a class pursuant to any arrangements with the Issuer or any of its Subsidiaries.

"**Spin-Off Securities**" means equity shares of an entity other than the Issuer or options, warrants or other rights to subscribe for or purchase equity shares of an entity other than the Issuer.

"**SSO Reference Date**" has the meaning provided in Condition 9.9(c) (*Certain Definitions*).

"**SSO Registration Date**" has the meaning provided in Condition 9.9(e) (*Provisions relating to any Share Settlement Option*).

"**Stock Exchange Dealing Day**" means a day (other than a Saturday or a Sunday) on which the Relevant Stock Exchange in respect of the Shares is open for business (whether or not such day is a dealing day) (other than a day on which such Relevant Stock Exchange is scheduled to close prior to its regular weekday closing time).

"**Subscription Agreement**" means the subscription agreement originally dated 13 November 2025 (as amended and restated on 16 December 2025) between the Issuer and the initial subscriber named therein in connection with the subscription and issuance of the Bonds and the Second Tranche Bonds.

"**Subsidiary**" means, in relation to any person (the "**first Person**") at any particular time, any other person (the "**second Person**") (i) whose affairs and policies the first Person controls or has the power to control, whether by ownership of shares, contract, the power to appoint or remove members of the governing body of the second Person or otherwise or (ii) whose assets, liabilities,

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equity, income, expenses and cash flows are, in accordance with applicable law and the International Standards on Auditing issued by the International Federation of Accountants (as amended, supplemented or re-issued from time to time), consolidated with those of the first Person in the consolidated financial statements of such person.

"**Tax Jurisdiction**" has the meaning provided in Condition 8 (*Taxation*).

"**Tax Withholding**" has the meaning provided in Condition 8 (*Taxation*).

"**Upcoming Amortised Payment Amount**" has the meaning provided in Condition 6.1 (*Conversion Period and Conversion Price*).

"**US Market**" means each of The Nasdaq Global Market, The Nasdaq Global Select Market and The New York Stock Exchange (or any of their respective successors).

"**US Share**" means any Share that is required pursuant to these Conditions to be issued or transferred and delivered in uncertificated form through the dematerialised securities trading system operated by DTC on exercise of Conversion Rights or the Share Settlement Option.

"**Volume Weighted Average Price**" means, in respect of a Share, such other Security or, as the case may be, a Spin-Off Security, on any dealing day in respect thereof, the volume weighted average price on such dealing day on the Relevant Stock Exchange of a Share or, as the case may be, such other Security or Spin-Off Security, as published by or derived from Bloomberg page HP (or any successor page) (setting 'PR094 VWAP (Vol Weighted Average Price)' or any other successor setting and using values not adjusted for any event occurring after such dealing day; and for the avoidance of doubt, all values will be determined with all adjustment settings on the DPDF Page, or any successor or similar setting, switched off) in respect of such Share or, as the case may be, such other Security or Spin-Off Security (all as determined by the Calculation Agent as at the Bloomberg Screen Observation Time in respect of such dealing day) (and for the avoidance of doubt such Bloomberg page for the Shares as at the Issue Date is NYXH BB Equity HP) if available or, in any other case, such other source (if any) as shall be determined to be appropriate by an Independent Adviser on such dealing day provided that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) if on any such dealing day (for the purposes of this definition, the "**Original Date**") such price is not available or cannot otherwise be determined as provided above, the Volume Weighted Average Price of a Share, such other Security or Spin-Off Security, as the case may be, in respect of such dealing day shall be the Volume Weighted Average Price, determined as provided above, on the immediately preceding dealing day in respect thereof on which the same can be so determined, provided however that if such immediately preceding dealing day falls prior to the fifth day before the Original Date, the Volume Weighted Average Price in respect of such dealing day shall be considered to be not capable of being determined pursuant to this proviso (a); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) if the Volume Weighted Average Price cannot be determined as aforesaid, the Volume Weighted Average Price of a Share, such other Security or Spin-Off Security, as the case may be, shall be determined as at the Original Date by an Independent Adviser in such manner as it shall determine to be appropriate,

and the Volume Weighted Average Price determined as aforesaid on or as at any dealing day shall, if not in the Relevant Currency, be translated if necessary into the Relevant Currency at the Prevailing Rate on such dealing day.

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References to any act or statute or any provision of any act or statute shall be deemed also to refer to any statutory modification or re-enactment thereof or any statutory instrument, order or regulation made thereunder or under such modification or re-enactment.

References to any issue or offer or grant to Shareholders or Existing Shareholders "**as a class**" or "**by way of rights**" shall be taken to be references to an issue or offer or grant to all or substantially all Shareholders or Existing Shareholders, as the case may be, other than Shareholders or Existing Shareholders, as the case may be, to whom, by reason of the laws of any territory or requirements of any recognised regulatory body or any other stock exchange or securities market in any territory or in connection with fractional entitlements, it is determined not to make such issue or offer or grant.

In making any calculation or determination of Reference Lowest Daily Market Price, Current Market Price or Volume Weighted Average Price, such adjustments (if any) shall be made and as the Calculation Agent or an Independent Adviser considers appropriate to reflect any consolidation or sub-division of the Shares or any issue of Shares by way of capitalisation of profits or reserves, or any like or similar event.

For the purposes of Conditions 6.1 (*Conversion Period and Conversion Price*), 6.2 (*Adjustment of Conversion Price*), 6.3 (*Retroactive Adjustments*), 6.9 (*Procedure for exercise of Conversion Rights*), 6.11 (*Ranking and entitlement*), 9.9 (*Share Settlement Option*) and 11 (*Undertakings*) only, (i) references to the "**issue**" of Shares or Shares being "**issued**" shall include the transfer and/or delivery of Shares, whether newly issued and allotted or previously existing or held by or on behalf of the Issuer or any of its Subsidiaries, and (ii) Shares held by or on behalf of the Issuer or any of its Subsidiaries (and which, in the case of Condition 6.2(d) (*Rights issues*) and 6.2(f) (*Issue of Securities to Shareholders*), do not rank for the relevant right or other entitlement) shall not be considered as or treated as "**in issue**" or "**issued**", or entitled to receive the relevant Dividend, right or other entitlement.

For the purposes of these Conditions, at all times each Bond (and the principal amount outstanding thereunder) shall be treated equally and as a single series for the purposes of calculating any percentage of the principal amount outstanding of Bonds (including, without limitation, for the purposes of determining any matters that requires the approval of the Bondholders or the Majority Bondholders or in relation to Conditions 11 (*Undertakings*) or 15 (*Amendment and Waiver*)).

**4.** **Registration and Transfer of Bonds**

**4.1** **Registration**

The Issuer will keep or will cause to be kept a Register as provided in Clause 4 (*Register and Title*) of the Bond Instrument.

**4.2** **Transfer**

Bonds may be transferred in accordance with the provisions of Clauses 4 (*Register and Title*) and 6 (*Transfer of Rights and Obligations*) of the Bond Instrument.

**5.** **Interest**

**5.1** **Interest Rate**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Interest Rate

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The Bonds bear interest from (and including) the Issue Date at the rate of 6.50 per cent. per annum (the "**Rate of Interest**") payable in arrear on each three-month anniversary date of the Concurrent Equity Raise (being 18 February, 18 May, 18 August and 18 November of each year) (each such date, an "**Interest Payment Date**), with the first Interest Payment Date falling on 18 February 2026 and with the final Interest Payment Date falling on the Original Final Maturity Date.

The amount of interest payable per each Bond in respect of any period (the "**Accrual Period**") which is, or is shorter than, an Interest Period (including, without limitation, interest payable on any Interest Payment Date, and interest payable in respect of an Advanced Amortised Payment Amount on an Advanced Amortisation Payment Date) shall be calculated by the Calculation Agent as the product (rounded to the nearest whole multiple of €0.01 (with €0.005 being rounded upwards)) of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the outstanding principal amount of such Bond (or, in the case of interest payable in respect of an Advanced Amortised Payment Amount on an Advanced Amortisation Payment Date, such Advanced Amortised Payment Amount);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the Rate of Interest; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) the applicable day count fraction determined in accordance with the Actual/Actual (ICMA) day count convention, being:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) where such Accrual Period is an Interest Period (other than the first Interest Period): 0.25; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) where such Accrual Period is the first Interest Period: a fraction, the numerator of which is the number of days in such first Interest Period and the denominator of which is the product of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) 92; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) 4, being the number of Interest Periods normally ending in any year;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(C) where such Accrual Period is shorter than an Interest Period, a fraction, the numerator of which is the number of days in such Accrual Period and the denominator of which is the product of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) the number of days in the Interest Period in which such Accrual Period falls (or, if such Interest Period is the first Interest Period, 92); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) 4, being the number of Interest Periods normally ending in any year.

For the avoidance of doubt, in circumstances where an Advanced Amortised Payment Date has occurred in respect of any Bond in an Interest Period, the relevant Advanced Amortisation Payment shall be ignored for the purposes of calculating the interest payable on the relevant Bond on the Interest Payment Date immediately following such Interest Period (so as to avoid any double counting in respect of interest paid in respect of such Advanced Amortisation Payment on such Advanced Amortised Payment Date).

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"**Interest Period**" means the period beginning on (and including) the Issue Date and ending on (but excluding) the first Interest Payment Date and each successive period beginning on (and including) an Interest Payment Date and ending on (but excluding) the next succeeding Interest Payment Date.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Interest Share Settlement Option Notice

In respect of any interest payment due on an Interest Payment Date (or an Advanced Amortisation Payment Date), such interest payment shall be paid by the Issuer in cash unless, subject to Condition 9.9(d) (*Annulment of Share Settlement Option*), the Issuer elects (in its sole discretion) to exercise the Share Settlement Option pursuant to and in accordance with Condition 9.9 (*Share Settlement Option*) in respect of all but not some only of the Bonds by giving notice thereof (an "**Interest Share Settlement Option Notice**") (which notice shall be irrevocable) to Bondholders in accordance with Condition 16 (*Notices*) by no later than 5:00 p.m. New York time on the second Qualifying Business Day prior to such Interest Payment Date (or, in the case of any interest payment due on an Advanced Amortisation Payment Date, by no later than 5:00 p.m. New York time on the second Qualifying Business Day prior to such Advanced Amortisation Payment Date).

**5.2** **Accrual of Interest**

Each Bond will cease to bear interest:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) where the Conversion Right shall have been exercised by a Bondholder from (and including) the Interest Payment Date immediately preceding the relevant Conversion Date or, if none, the Issue Date (subject in any such case as provided in Condition 6.12 (*Interest on Conversion*)); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) where such Bond is redeemed or repaid pursuant to Condition 7 (*Redemption of Bonds*) or Condition 10 (*Events of Default*), from (and including) the due date for redemption or repayment thereof (which shall be, for the avoidance of doubt, in respect of any principal due on any Amortisation Payment Date (including, for the avoidance of doubt, any Advanced Amortisation Payment Date) in respect of which a Share Settlement applies, such Amortisation Payment Date) unless payment of principal is improperly withheld or refused or, following any election to exercise the Share Settlement Option, the Issuer fails duly to perform its obligations to issue or transfer and deliver the relevant Deliverable Shares in accordance with Condition 9.9 (*Share Settlement Option*) in which event interest will continue to accrue at the rate specified in Condition 5.1 (*Interest Rate*) (both before and after judgment) to (but excluding) the Relevant Date or, as the case may be, the date on which such issue and delivery of Deliverable Shares is duly made in accordance with Condition 9.9 (*Share Settlement Option*).

**5.3** **Default Interest**

If the Issuer fails to pay any amount payable by it on its due date, default interest shall accrue on the overdue amount from (and including) the due date up to (but excluding) the date of actual payment at a rate which is two per cent. higher than the Rate of Interest. Accrued default interest shall not be capitalised.

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**6.** **Conversion of Bonds**

**6.1** **Conversion Period and Conversion Price**

Subject to and as provided in these Conditions, each Bond in the original principal amount of €100,000 shall entitle the holder to convert the whole of the then outstanding principal amount of such Bond into new and/or existing Share(s) as determined by the Issuer, credited as fully paid (a "**Bond Conversion Right**").

Subject to and as provided in these Conditions, each Bond shall entitle the holder to contribute in kind in the Issuer its receivable for the amount of the relevant Amortised Payment Amount (including, for the avoidance of doubt, any Advanced Amortised Payment Amount) that would be payable on the next following Amortisation Payment Date (including, for the avoidance of doubt, any Advanced Amortisation Payment Date) in respect of such Bond (any such Amortised Payment Amount (including, for the avoidance of doubt, any Advanced Amortised Payment Amount), an "**Upcoming Amortised Payment Amount**" in respect of such Bond) against issuance of new Share(s), credited as fully paid (the "**Amortisation Conversion Right**" and together with the Bond Conversion Right the "**Conversion Rights**").

The number of Shares to be issued or transferred and delivered on exercise of a Conversion Right shall be equal to the Reference Shares in respect of such exercise, subject to Condition 6.3 (*Retroactive Adjustments*).

The Conversion Price per Share is initially €5.00 (the "**Initial Conversion Price**"). The Conversion Price is subject to adjustment in the circumstances described in Condition 6.2 (*Adjustment of Conversion Price*) and Condition 6.4 (*Conversion Price Reset*). The expression "**Conversion Price**" shall be construed accordingly.

Subject to and as provided in these Conditions (including, without limitation, Condition 6.9 (*Procedure for exercise of Conversion Rights*)), the Conversion Right in respect of a Bond (including the right to convert any Upcoming Amortised Payment Amounts in respect thereof) may be exercised, at the option of the holder thereof, at any time subject to any applicable fiscal or other laws or regulations and as hereinafter provided from (and including) the Issue Date to (and including) the date falling two Qualifying Business Days prior to the Final Maturity Date (or, in the case of the right to convert any Upcoming Amortised Payment Amount, to (and including) the date falling one Qualifying Business Day prior to the Amortisation Payment Date in relation to such Upcoming Amortised Payment Amount), unless there shall be a default in making payment in respect of such Bond on any such date fixed for redemption, in which event the Conversion Right shall extend up to (and including) the date on which the full amount of such payment becomes available for payment and notice of such availability has been given to Bondholders or, if earlier, the Final Maturity Date; *provided that*, in each case, if such final date for the exercise of Conversion Rights is not a Qualifying Business Day, then the period for exercise of Conversion Rights by Bondholders shall end on (and including) the immediately preceding Qualifying Business Day.

The period during which Conversion Rights may (subject as provided below) be exercised by a Bondholder is referred to as the "**Conversion Period**".

Conversion Rights shall expire immediately upon the commencement of liquidation, bankruptcy, insolvency or other analogous proceedings relating to the Issuer, dissolution of the Issuer or removal from the Belgian Crossroads Bank for Enterprises of the Issuer.

Fractions of Shares will not be issued or transferred and delivered on exercise of Conversion Rights or pursuant to Condition 6.3 (*Retroactive Adjustments*) and no cash payment or other adjustment

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will be made in lieu thereof. However, if the Conversion Right in respect of more than one Bond (or any Upcoming Amortised Payment Amounts that would be payable on more than one Bond, as the case may be) is exercised at any one time such that Shares to be issued or transferred and delivered on conversion or pursuant to Condition 6.3 (*Retroactive Adjustments*) are to be registered in the same name, the number of such Shares to be issued or transferred and delivered in respect thereof shall, in accordance with the definition of 'Reference Shares', be calculated by the Calculation Agent on the basis of the aggregate principal amount of such Bonds (or aggregate amount of the relevant Upcoming Amortised Payment Amounts, as the case may be) being so converted and rounded down to the nearest whole number of Shares.

Conversion Rights may not be exercised (i) following the giving of notice by the holders of at least one-quarter in principal amount of the Bonds then outstanding pursuant to Condition 10 (*Events of Default*); (ii) in respect of a Bond in respect of which the relevant holder has exercised its right to require the Issuer to redeem pursuant to Condition 7.2 (*Redemption at the Option of Bondholders (Relevant Event*)) (but without prejudice to the rights of Bondholders to require the Issuer to issue or transfer and deliver Shares as provided therein); or (iii) on any Interest Payment Date or Amortisation Payment Date or the dealing day immediately prior to such date.

Subject to the right of the Issuer to make a Cash Alternative Election (which shall be exercisable solely in the event and to the extent that the issue and delivery of Shares in respect of any exercise of Conversion Rights would cause the issue, conversion or delivery of more Shares than permitted by applicable law pursuant to Condition 12 (*Regulatory Share Cap*)), the Issuer will procure that Shares to be issued or transferred and delivered on exercise of Conversion Rights will be issued or transferred and delivered to, or to the order of, the person or persons specified in the relevant Payment Details by the relevant Bondholder in accordance with the provisions of Condition 6.9 (*Procedure for exercise of Conversion Rights*). Such Shares (other than Additional Shares) will be deemed to be issued or transferred and delivered as of the relevant Registration Date and the Issuer shall procure that such Registration Date shall occur as soon as practicable after the relevant Conversion Date (and in any event no later than the relevant Scheduled Delivery Date in respect of such Shares). Any Additional Shares to be issued or transferred and delivered pursuant to Condition 6.3 (*Retroactive Adjustments*) will be deemed to be issued or transferred and delivered as of the relevant Additional Registration Date and the Issuer shall procure that such Additional Registration Date shall occur as soon as practicable after the relevant Reference Date (and in any event no later than the relevant Scheduled Delivery Date in respect of such Additional Shares).

**6.2** **Adjustment of Conversion Price**

Subject to the provisions of this Condition 6 (*Conversion of Bonds*), upon the occurrence of any of the events described below (other than where the Applicable Adjustment Record Date in respect thereof falls prior to the Issue Date), the Conversion Price shall be adjusted by the Calculation Agent as follows:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Consolidation, reclassification, redesignation or subdivision

If and whenever there shall be a consolidation, reclassification, redesignation or subdivision affecting the number of Shares in issue, the Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately prior to the Effective Date by the following fraction:

A

—

B

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where:

A is the aggregate number of Shares in issue immediately before such consolidation, reclassification, redesignation or subdivision, as the case may be; and

B is the aggregate number of Shares in issue immediately after, and as a result of, such consolidation, reclassification, redesignation or subdivision, as the case may be.

Such adjustment shall become effective on the Effective Date.

"**Effective Date**" means, in respect of this Condition 6.2(a), the date on which the consolidation, reclassification, redesignation or sub-division, as the case may be, takes effect (or, if later, the Brussels and New York business day falling immediately after the record date or other due date for the establishment of entitlement in respect thereof).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Capitalisation of profits or reserves

If and whenever the Issuer shall issue any Shares to the Shareholders by way of capitalisation of profits or reserves (including any share premium account or capital redemption reserve) other than where such issue of Shares constitutes a Scrip Dividend, the Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately prior to the Effective Date by the following fraction:

A

—

B

where:

A is the aggregate number of Shares in issue immediately before such issue; and

B is the aggregate number of Shares in issue immediately after such issue.

Such adjustment shall become effective on the Effective Date.

"**Effective Date**" means, in respect of this Condition 6.2(b), the date of issue of such Shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Dividends

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) If and whenever the Ex-Date of a Dividend shall occur, the Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately prior to the Effective Date by the following fraction:

A – B

——

A

where:

A is the Current Market Price of one Share on the Ex-Date in respect of such Dividend; and

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| | |
|:---|:---|
| B | is the portion of the Fair Market Value of the aggregate Dividend attributable to one Share, with such portion being determined by dividing the Fair Market Value of the aggregate Dividend by the number of Shares entitled to receive the relevant Dividend (or, in the case of a purchase, redemption or buy back of Shares or any depositary or other receipts or certificates representing Shares by or on behalf of the Issuer or any Subsidiary of the Issuer, by the number of Shares in issue immediately following such purchase, redemption or buy back, and treating as not being in issue any Shares, or any Shares represented by depositary or other receipts or certificates, purchased, redeemed or bought back). |

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Such adjustment shall become effective on the Effective Date.

"**Effective Date**" means, in respect of this Condition 6.2(c), the later of (A) the first Brussels and New York business day on which the Fair Market Value of the relevant Dividend is capable of being determined as provided herein, and (B) the Brussels and New York business day falling immediately after the record date or other due date for the establishment of entitlement in respect of such Dividend.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) For the purposes of the above, Fair Market Value shall (subject as provided in the definition of "Dividend" and in the definition of "Fair Market Value") be determined as at the Ex-Date in respect of the relevant Dividend.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) Rights issues

If and whenever the Issuer or any Subsidiary of the Issuer or (at the direction or request or pursuant to any arrangements with the Issuer or any Subsidiary of the Issuer) any other company, person or entity shall issue any Shares to Shareholders as a class by way of rights, or shall issue or grant to Shareholders as a class by way of rights, any options, warrants or other rights to subscribe for or purchase or otherwise acquire any Shares, or any other Securities which by their terms of issue carry (directly or indirectly) rights of conversion into, or exchange or subscription for, or the right to otherwise acquire, any Shares (or shall grant any such rights in respect of existing Securities so issued), in each case at a consideration receivable per Share (based, where appropriate, on such number of Shares as is determined pursuant to the definition of "C" and the proviso below) which is less than 95 per cent. of the Current Market Price per Share on the Ex-Date in respect of the relevant issue or grant, the Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately prior to the Effective Date by the following fraction:

A+B

——

A+C

where:

A is the number of Shares in issue on such Ex-Date;

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| | |
|:---|:---|
| B | is the number of Shares which the aggregate consideration (if any) receivable for the Shares issued by way of rights, or for the Securities issued by way of rights and upon exercise of rights of conversion into, or exchange or subscription for, or the right to otherwise acquire, Shares, or for the options or warrants or other rights issued by way of rights and for the total number of Shares deliverable on |

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the exercise thereof, would purchase at such Current Market Price per Share on the Ex-Date; and

C is the number of Shares to be issued or, as the case may be, the maximum number of Shares which may be issued upon exercise of such options, warrants or rights calculated as at the date of issue of such options, warrants or rights or upon conversion or exchange or exercise of rights of subscription or purchase or other rights of acquisition in respect thereof at the initial conversion, exchange, subscription, purchase or acquisition price or rate;

provided that if on such Ex-Date such number of Shares is to be determined by reference to the application of a formula or other variable feature or the occurrence of any event at some subsequent time, then for the purposes of this Condition 6.2(d), "C" shall be determined by the application of such formula or variable feature or as if the relevant event occurs or had occurred as at such Ex-Date and as if such conversion, exchange, subscription, purchase or acquisition had taken place on such Ex-Date.

Such adjustment shall become effective on the Effective Date.

"**Effective Date**" means, in respect of this Condition 6.2(d), the later of (A) the first Brussels and New York business day on which the adjusted Conversion Price is capable of being determined in accordance with this Condition 6.2(d), and (B) the Brussels and New York business day falling immediately after the record date or other due date for the establishment of entitlement in respect of the relevant issue or grant.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) Issue of Securities to Shareholders

If and whenever the Issuer or any Subsidiary of the Issuer or (at the direction or request or pursuant to any arrangements with the Issuer or any Subsidiary of the Issuer) any other company, person or entity shall (other than in the circumstances the subject of Condition 6.2(d) above and other than constituting a Scrip Dividend) issue any Securities to Shareholders as a class by way of rights or grant to Shareholders as a class by way of rights any options, warrants or other rights to subscribe for or purchase or otherwise acquire any Securities, the Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately prior to the Effective Date by the following fraction:

A – B

——

A

where:

A is the Current Market Price of one Share on the Ex-Date in respect of the relevant issue or grant; and

B is the Fair Market Value on such Ex-Date of the portion of the rights attributable to one Share.

Such adjustment shall become effective on the Effective Date.

"**Effective Date**" means, in respect of this Condition 6.2(e), the later of (A) the first Brussels and New York business day on which the adjusted Conversion Price is capable of being determined in accordance with this Condition 6.2(e), and (B) the Brussels and New

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York business day falling immediately after the record date or other due date for the establishment of entitlement in respect of the relevant issue or grant.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) Issue of Shares at below Current Market Price

If and whenever the Issuer shall issue (otherwise than as mentioned in Condition 6.2(d) above) wholly for cash or for no consideration any Shares (other than Shares issued on conversion of, or pursuant to any exercise of the Share Settlement Option under, the Bonds (which term shall for this purpose include any Further Bonds) or on the exercise of any rights of conversion into, or exchange or subscription for or purchase of, or rights to otherwise acquire, Shares and other than constituting a Scrip Dividend) or if and whenever the Issuer or any Subsidiary of the Issuer or (at the direction or request or pursuant to any arrangements with the Issuer or any Subsidiary of the Issuer) any other company, person or entity shall issue or grant (otherwise than as mentioned in Condition 6.2(d) above) wholly for cash or for no consideration any options, warrants or other rights to subscribe for or purchase or otherwise acquire any Shares (other than the Bonds, which term shall for this purpose include any Further Bonds), in each case at consideration receivable per Share (based, where appropriate, on such number of Shares as is determined pursuant to the definition of "C" and the proviso below) which is less than 95 per cent. of the Current Market Price per Share on the date of first public announcement of the terms of such issue or grant, the Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately prior to the Effective Date by the following fraction:

A+B

——

A+C

where:

A is the number of Shares in issue immediately before the date of first public announcement of the terms of such issue of Shares or issue or grant of options, warrants or other rights as provided above;

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| | |
|:---|:---|
| B | is the number of Shares which the aggregate consideration (if any) receivable for the issue of such Shares or, as the case may be, for the Shares to be issued or otherwise made available upon the exercise of any such options, warrants or rights, would purchase at such Current Market Price per Share on the date of first public announcement of the terms of such issue or grant; and |

---

C is the number of Shares to be issued pursuant to such issue of such Shares or, as the case may be, the maximum number of Shares which may be issued upon exercise of such options, warrants or rights calculated as at the date of issue of such options, warrants or rights;

provided that if on the date of first public announcement of the terms of such issue or grant (as used in this Condition 6.2(f), the "**Specified Date**") such number of Shares is to be determined by reference to the application of a formula or other variable feature or the occurrence of any event at some subsequent time, then for the purposes of this Condition 6.2(f), "C" shall be determined by the application of such formula or variable feature or as if the relevant event occurs or had occurred as at the Specified Date and as if such conversion, exchange, subscription, purchase, acquisition had taken place on the Specified Date.

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Such adjustment shall become effective on the Effective Date.

"**Effective Date**" means, in respect of this Condition 6.2(f), the later of (A) the date of issue of such Shares or, as the case may be, the issue or grant of such options, warrants or rights, and (B) the first Brussels and New York business day on which the adjusted Conversion Price is capable of being determined in accordance with this Condition 6.2(f).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) Other issues

If and whenever the Issuer or any Subsidiary of the Issuer or (at the direction or request of or pursuant to any arrangements with the Issuer or any Subsidiary of the Issuer) any other company, person or entity shall (otherwise than as mentioned in Conditions 6.2(d), (e) or (f) above) issue wholly for cash or for no consideration any Securities (other than the Bonds which term shall for this purpose exclude any Further Bonds and other than constituting a Scrip Dividend) which by their terms of issue carry (directly or indirectly) rights of conversion into, or exchange or subscription for, purchase of, or rights to otherwise acquire, Shares (or shall grant any such rights in respect of existing Securities so issued) or Securities which by their terms might be reclassified or redesignated as Shares, and the consideration per Share (based, where appropriate, on such number of Shares as is determined pursuant to the definition of "C" and the proviso below) receivable upon conversion, exchange, subscription, purchase, acquisition, reclassification or redesignation is less than 95 per cent. of the Current Market Price per Share on the date of first public announcement of the terms of the issue of such Securities (or the terms of such grant), the Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately prior to the Effective Date by the following fraction:

A+B

——

A+C

where:

A is the number of Shares in issue immediately before the date of first public announcement of the terms of the issue of such Securities (or the terms of such grant);

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| | |
|:---|:---|
| B | is the number of Shares which the aggregate consideration (if any) receivable for the Shares to be issued or otherwise made available upon conversion or exchange or upon exercise of the right of subscription, purchase or acquisition attached to such Securities or, as the case may be, for the Shares to be issued or to arise from any such reclassification or redesignation would purchase at such Current Market Price per Share on the date of first public announcement of the terms of the issue of such Securities (or the terms of such grant); and |

---

C is the maximum number of Shares to be issued or otherwise made available upon conversion or exchange of such Securities or upon the exercise of such right of subscription, purchase or acquisition attached thereto at the initial conversion, exchange, subscription, purchase or acquisition price or rate or, as the case may be, the maximum number of Shares which may be issued or arise from any such reclassification or redesignation;

provided that if on the date of first public announcement of the terms of the issue of such Securities (or the terms of such grant) (as used in this Condition 6.2(g), the "**Specified** 

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**Date**") such number of Shares is to be determined by reference to the application of a formula or other variable feature or the occurrence of any event at some subsequent time (which may be when such Securities are converted or exchanged or rights of subscription, purchase or acquisition are exercised or, as the case may be, such Securities are reclassified or redesignated or at such other time as may be provided), then for the purposes of this Condition 6.2(g), "C" shall be determined by the application of such formula or variable feature or as if the relevant event occurs or had occurred as at the Specified Date and as if such conversion, exchange, subscription, purchase or acquisition, reclassification or, as the case may be, redesignation had taken place on the Specified Date.

Such adjustment shall become effective on the Effective Date.

"**Effective Date**" means, in respect of this Condition 6.2(g), the later of (A) the date of issue of such Securities or, as the case may be, the grant of such rights, and (B) the first Brussels and New York business day on which the adjusted Conversion Price is capable of being determined in accordance with this Condition 6.2(g).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) Modification of rights

If and whenever there shall be any modification of the rights of conversion, exchange, subscription, purchase or acquisition attaching to any Securities (other than the Bonds, which term shall for this purpose include any Further Bonds) which by their terms of issue carry (directly or indirectly) rights of conversion into, or exchange or subscription for, or the right to otherwise acquire, any Shares (other than in accordance with the terms (including terms as to adjustment) applicable to such Securities upon issue) so that following such modification the consideration per Share (based, where appropriate, on such number of Shares as is determined pursuant to the definition of "C" and the proviso below) receivable upon conversion, exchange, subscription, purchase or acquisition has been reduced and is less than 95 per cent. of the Current Market Price per Share on the date of first public announcement of the terms for such modification, the Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately prior to the Effective Date by the following fraction:

A+B

——

A+C

where:

A is the number of Shares in issue immediately before the date of first public announcement of the terms for such modification;

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| | |
|:---|:---|
| B | is the number of Shares which the aggregate consideration (if any) receivable for the Shares to be issued or otherwise made available upon conversion or exchange or upon exercise of the right of subscription, purchase or acquisition attached to the Securities so modified would purchase at such Current Market Price per Share on the date of first public announcement of the terms for such modification or, if lower, the existing conversion, exchange, subscription, purchase or acquisition price or rate of such Securities; and |

---

C is the maximum number of Shares which may be issued or otherwise made available upon conversion or exchange of such Securities or upon the exercise of such rights of subscription, purchase or acquisition attached thereto at the

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modified conversion, exchange, subscription, purchase or acquisition price or rate but giving credit in such manner as the Calculation Agent shall consider appropriate for any previous adjustment under this Condition 6.2(h) or Condition 6.2(g) above;

provided that if on the date of first public announcement of the terms of such modification (as used in this Condition 6.2(h), the "**Specified Date**") such number of Shares is to be determined by reference to the application of a formula or other variable feature or the occurrence of any event at some subsequent time (which may be when such Securities are converted or exchanged or rights of subscription, purchase or acquisition are exercised or at such other time as may be provided), then for the purposes of this Condition 6.2(h), "C" shall be determined by the application of such formula or variable feature or as if the relevant event occurs or had occurred as at the Specified Date and as if such conversion, exchange, subscription, purchase or acquisition had taken place on the Specified Date.

Such adjustment shall become effective on the Effective Date.

"**Effective Date**" means, in respect of this Condition 6.2(h), the later of (A) the date of modification of the rights of conversion, exchange, subscription, purchase or acquisition attaching to such Securities, and (B) the first Brussels and New York business day on which the adjusted Conversion Price is capable of being determined in accordance with this Condition 6.2(h).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) Certain arrangements

If and whenever the Issuer or any Subsidiary of the Issuer or (at the direction or request of or pursuant to any arrangements with the Issuer or any Subsidiary of the Issuer) any other company, person or entity shall offer any Shares or such other Securities in connection with which Shareholders as a class are entitled to participate in arrangements whereby such Shares or Securities may be acquired by them (except where the Conversion Price falls to be adjusted under Conditions 6.2(b), (c), (d), (e), (f), or (g) above or (j) below (or, where applicable, would fall to be so adjusted if the relevant issue or grant was at less than 95 per cent. of the Current Market Price per Share on the relevant day)), the Conversion Price shall be adjusted by multiplying the Conversion Price in force immediately prior to the Effective Date by the following fraction:

A – B

——

A

where:

A is the Current Market Price of one Share on the Ex-Date in respect of the relevant offer; and

B is the Fair Market Value on such Ex-Date of the portion of the relevant offer attributable to one Share.

Such adjustment shall become effective on the Effective Date.

"**Effective Date**" means, in respect of this Condition6.2(i), the later of (A) the first Brussels and New York business day on which the adjusted Conversion Price is capable of being determined in accordance with this Condition 6.2(i), and (B) the Brussels and New York

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business day falling immediately after the record date or other due date for the establishment of entitlement in respect of the relevant offer.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(j) Relevant Event

Subject as provided in the final paragraph of this Condition 6.2(j), if a Relevant Event shall occur, then, upon any exercise of Conversion Rights where the Conversion Date falls during the Relevant Event Period in respect of such Relevant Event, the Conversion Price solely for the purpose of such exercise (the "**Relevant Event Conversion Price**") shall be determined as set out below:

![Graphic](nyxh-20251231xex4d23002.jpg)

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| | |
|:---|:---|
| where:  |  |
| RECP  | is the Relevant Event Conversion Price  |
| OCP  | is the Conversion Price in effect on the relevant Conversion Date  |
| CP  | 25 per cent.  |
| c  | is the number of days from and including the date the Relevant Event occurs to but excluding the Original Final Maturity Date  |
| t  | is the number of days from and including the Issue Date to but excluding the Original Final Maturity Date  |

---

In the case of a Change of Control, the foregoing provisions of this Condition 6.2(j) will only become effective if and when the Change of Control Resolutions are approved and filed with the clerk's office of the competent Enterprise Court in accordance with the provisions of the Belgian Companies and Associations Code.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(k) Other adjustments

Subject to Condition 6.6 (*Employee Incentive Issuances*), if either the Issuer (following consultation with the Calculation Agent) or the Majority Bondholders (each acting reasonably) determines that an adjustment (for the purpose of compensating for dilution) should be made to the Conversion Price (or that a determination should be made as to whether an adjustment should be made) as a result of one or more circumstances not referred to above in this Condition 6.2 (*Adjustment of Conversion Price*) (except for events specifically excluded from the operation of Conditions 6.2(a) to (j) above), the Issuer shall, at its own expense and acting reasonably, request an Independent Adviser to determine, in consultation with the Calculation Agent, if different, as soon as practicable what adjustment (if any) to the Conversion Price is fair and reasonable to take account thereof and the date on which such adjustment (if any) should take effect and upon such determination such adjustment (if any) shall be made and shall take effect in accordance with such determination, provided that an adjustment shall only be made pursuant to this Condition 6.2(k) if such Independent Adviser is so requested to make such a determination not more than 21 days after the date on which the relevant circumstances arises (or, if later, 21 days after the date on which the relevant circumstances are made public or otherwise are made known to the Bondholders) and if the adjustment would result in a reduction to the Conversion Price.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(l) Modifications

Notwithstanding the foregoing provisions:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) where the events or circumstances giving rise to any adjustment pursuant to this Condition 6.2 (*Adjustment of Conversion Price*) have already resulted or will result in an adjustment to the Conversion Price or where the events or circumstances giving rise to any adjustment arise by virtue of any other events or circumstances which have already given or will give rise to an adjustment to the Conversion Price or where more than one event which gives rise to an adjustment to the Conversion Price occurs within such a short period of time that, in the opinion of the Issuer (acting reasonably) and following consultation with the Calculation Agent, a modification to the operation of the adjustment provisions is required to give the intended result, such modification shall be made to the operation of the adjustment provisions as may be determined by an Independent Adviser to be in its opinion appropriate to give the intended result;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) such modification shall be made to the operation of these Conditions as may be determined by an Independent Adviser, in consultation with the Calculation Agent (if different), to be in its opinion appropriate (A) to ensure that an adjustment to the Conversion Price or the economic effect thereof shall not be taken into account more than once and (B) to ensure that the economic effect of a Dividend is not taken into account more than once; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) other than pursuant to Condition 6.2(a) (*Consolidation, reclassification, redesignation or subdivision*), no adjustment shall be made that would result in an increase to the Conversion Price.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(m) Calculation of consideration

For the purpose of any calculation of the consideration receivable or price pursuant to Conditions 6.2(d), (f), (g) and (h) above, the following provisions shall apply:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the aggregate consideration receivable or price for Shares issued for cash shall be the amount of such cash;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) (x) the aggregate consideration receivable or price for Shares to be issued or otherwise made available upon the conversion or exchange of any Securities shall be deemed to be the consideration or price received or receivable for any such Securities (whether on one or more occasions) and (y) the aggregate consideration receivable or price for Shares to be issued or otherwise made available upon the exercise of rights of subscription attached to any Securities or upon the exercise of any options, warrants or rights shall be deemed to be that part (which may be the whole) of the consideration or price received or receivable for such Securities or, as the case may be, for such options, warrants or rights which are attributed by the Issuer to such rights of subscription or, as the case may be, such options, warrants or rights or, if no part of such consideration or price is so attributed, the Fair Market Value of such rights of subscription or, as the case may be, such options, warrants or rights as at the relevant Ex-Date referred to in Condition 6.2(d) above or as at the relevant date of first public announcement referred to in Conditions 6.2(f), (g) and (h) above, as the case may be, plus in the case of each of (x) and (y) above in this paragraph, the additional minimum consideration receivable or price (if any) upon the conversion or exchange of such Securities, or upon the exercise of such

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rights of subscription attached thereto or, as the case may be, upon exercise of such options, warrants or rights and (z) the consideration receivable or price per Share upon the conversion or exchange of, or upon the exercise of such rights of subscription attached to, such Securities or, as the case may be, upon the exercise of such options, warrants or rights shall be the aggregate consideration or price referred to in (x) or (y) above in this paragraph (as the case may be) divided by the number of Shares to be issued upon such conversion or exchange or exercise at the initial conversion, exchange or subscription price or rate, all as determined by the Calculation Agent;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) if the consideration or price determined pursuant to (i) or (ii) above (or any component thereof) shall be expressed in a currency other than the Relevant Currency (other than in circumstances where such consideration is also expressed in the Relevant Currency, in which case such consideration shall be treated as expressed in the Relevant Currency in an amount equal to the amount of such consideration when so expressed in the Relevant Currency), it shall be converted by the Calculation Agent into the Relevant Currency at the Prevailing Rate on the relevant Ex-Date (for the purposes of Condition 6.2(d) above) or the relevant date of first public announcement (for the purposes of Conditions 6.2(f), (g) and (h) above, as the case may be);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) in determining the consideration or price pursuant to the above, no deduction shall be made for any commissions or fees (howsoever described) or any expenses paid or incurred for any underwriting, placing or management of the issue of the relevant Shares or such other Securities or options, warrants or rights, or otherwise in connection therewith;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) the consideration or price shall be determined as provided above on the basis of the consideration or price received, receivable, paid or payable, regardless of whether all or part thereof is received, receivable, paid or payable by or to the Issuer or another entity;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) if as part of the same transaction, Shares shall be issued or issuable for a consideration receivable in more than one or in different currencies then the consideration receivable per Share shall be determined by dividing the aggregate consideration (determined as aforesaid and converted, if and to the extent not in the Relevant Currency, into the Relevant Currency as aforesaid) by the aggregate number of Shares so issued; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) references in these Conditions to "cash" includes any promise or undertaking to pay cash or any release or extinguishment of, or set-off against, a liability or obligation to pay a cash amount.

**6.3** **Retroactive Adjustments**

If a Retroactive Adjustment occurs in relation to any exercise of Conversion Rights (other than where there are no Physically Settled Shares in respect of such exercise of Conversion Rights), the Issuer shall procure that there shall be issued or transferred and delivered to, or to the order of, the relevant Bondholder and in accordance with the Payment Details, such additional number of Shares (if any) (the "**Additional Shares**") as, together with the Physically Settled Shares issued or transferred and delivered in the relevant exercise of Conversion Rights, is equal to the number of Physically Settled Shares which would have been required to be issued or transferred and delivered on such exercise and subsequent exchange if the relevant adjustment to the Conversion Price had

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been made and become effective immediately prior to the relevant Conversion Date (such number of Physically Settled Shares as aforesaid being for this purpose calculated as:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) where such exercise of Conversion Rights is not the subject of a Cash Alternative Election, the Reference Shares in respect of such exercise of Conversion Rights determined for this purpose by reference to such deemed Conversion Price as aforesaid; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) where such exercise of Conversion Rights is the subject of a Cash Alternative Election, the difference between:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) such number of Reference Shares as is determined pursuant to paragraph (a); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the product of (x) such number of Reference Shares determined as aforesaid and (y) the Cash Settlement Ratio in respect of such exercise of Conversion Rights),

all as determined by the Calculation Agent or an Independent Adviser, *provided that* if in the case of Conditions 6.2(b), 6.2(c), 6.2(d), 6.2(e) or 6.2(i) the relevant Bondholder shall be entitled to receive the relevant Shares, Dividends or such other Securities in respect of the Reference Shares to be issued and/or transferred and delivered to it, then the relevant Bondholder shall not be entitled to receive Additional Shares in relation to such Retroactive Adjustment.

**6.4** **Conversion Price Reset**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Subject to the paragraph (b) below, in the event of any Qualifying Equity Raise (whether on one or more occasions) completed by the Issuer or any Subsidiary of the Issuer or any of their respective affiliates at any time from (and including) the Issue Date, the Conversion Price will be adjusted on the date of completion of such Qualifying Equity Raise (or, if an adjustment to the Conversion Price is required to be made pursuant to Condition 6.2 (*Adjustment of Conversion Price*) in respect of such Qualifying Equity Raise, on the later of (i) the date on which such adjustment becomes effective, and (ii) the date of completion of such Qualifying Equity Raise) (the "**Equity Raise Reset Date**") by the Calculation Agent to be equal to the Placing Price in respect of such Qualifying Equity Raise.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) An adjustment to the Conversion Price in respect of a Qualifying Equity Raise pursuant to this Condition 6.4 *Conversion Price Reset*) (such adjustment, a "**Conversion Price Reset**") shall be made only if the Conversion Price so adjusted is lower than the Conversion Price that would, but for the operation of this Condition 6.4 (*Conversion Price Reset*), be in effect on the Equity Raise Reset Date.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Any adjustment to the Conversion Price pursuant to this Condition 6.4 (*Conversion Price Reset*) shall become effective as of the Equity Raise Reset Date (*provided that*, in the case of an adjustment to the Conversion Price in respect of a Qualifying Equity Raise pursuant to this Condition 6.4 (*Conversion Price Reset*), if an adjustment to the Conversion Price is required to be made pursuant to Condition 6.2 (*Adjustment of Conversion Price*) in respect of such Qualifying Equity Raise, the adjustment to the Conversion Price pursuant to this Condition 6.4 (*Conversion Price Reset*) shall be deemed to have occurred after such adjustment required to be made pursuant to Condition 6.2 (*Adjustment of Conversion Price*)) and notice of any such adjustment shall be given by the Issuer to Bondholders in accordance with Condition 16 (*Notices*).

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For the purposes of these Conditions:

"**Equity Raise**" means, other than in respect of an Exempt Transaction:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) any issuance of new Shares or any sale of existing Shares previously held by the Issuer or any Subsidiary or affiliate of the Issuer (in each case other than upon exercise of rights of conversion into, or exchange or subscription for, or the right to otherwise acquire, any Shares attached to any Equity-Linked Rights); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) any issuance of any other Securities (including without limitation warrants and options) or other right which by their terms of issue carry (directly or indirectly) rights of conversion into, or exchange or subscription for, or the right to otherwise acquire, any Shares (any such Securities or rights, "**Equity-Linked Rights** ").

"**Exempt Transaction**" means:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the issuance of any Excluded Instruments or the issuance of any Shares in connection with an exercise of any Excluded Instrument by the holder or beneficiary thereof; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) any LTIP Issuance or any Shares or other Equity-Linked Rights being issued, offered, exercised, allotted, purchased, appropriated, modified, granted or transferred pursuant to any LTIP Issuance, or any Shares or other Equity-Linked Rights upon any exercise of rights of conversion into, or exchange or subscription for, or the right to otherwise acquire, any Shares attached to any Equity-Linked Rights issued, offered, allotted or granted pursuant to any LTIP Issuance, where "**LTIP Issuance**" means any issuance, offer, allotment or grant of Shares or Equity-Linked Rights (in each case completed on or after the Issue Date) by the Issuer to, or for the benefit of, employees, officers and directors of the Issuer or any of its Subsidiaries and in each case pursuant to any employee incentive plans of the Issuer and/or its Subsidiaries, *provided that* such plans are duly approved by the Issuer's board of directors (including independent non-executive directors).

"**Placing Price**" means, in respect of any Qualifying Equity Raise, the Placing Proceeds in respect of such Qualifying Equity Raise divided by:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) (other than in the case of a Qualifying Equity Raise comprising the issuance of Equity-Linked Rights) the number of Shares comprised in such Qualifying Equity Raise; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) (in the case of a Qualifying Equity Raise comprising the issuance of Equity-Linked Rights) such number of Shares as is determined in a manner consistent with Conditions 6.2(d), 6.2(f) and 6.2(g) (as applicable),

in each case rounded down (if necessary) to the nearest whole multiple of €0.0001, as determined by the Issuer acting reasonably and in consultation with the Calculation Agent.

"**Placing Proceeds**" means, in respect of any Equity Raise:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) (other than in the case of an Equity Raise comprising the issuance of Equity-Linked Rights) the aggregate amount of the gross cash proceeds received by the Issuer (and/or any Subsidiary of the Issuer, or any of their respective affiliates) in respect of such Equity Raise; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) (in the case of an Equity Raise comprising the issuance of Equity-Linked Rights) the aggregate consideration receivable per Share determined in a manner consistent with Conditions 6.2(d), 6.2(f), 6.2(g) and 6.2(m) (as applicable),

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(in each case translated if necessary into EUR at the Prevailing Rate on the date of first public announcement of the terms of such Equity Raise) as determined by the Issuer acting reasonably and in consultation with the Calculation Agent.

"**Qualifying Equity Raise**" means any Relevant Equity Raise if the Placing Proceeds of such Relevant Equity Raise, together with the Placing Proceeds in respect of any other previous Relevant Equity Raise (disregarding for this purpose the entirety of any Relevant Equity Raise if any part or the entirety of such Relevant Equity Raise was previously taken into account in the determination of any previous Qualifying Equity Raise), are equal to or greater than €2 million, as determined by the Issuer acting reasonably and in consultation with the Calculation Agent.

"**Relevant Equity Raise**" means any Equity Raise the Placing Price in respect of which is lower than the Conversion Price in effect on the date of first public announcement of the terms of such Equity Raise.

**6.5** **Decision and Determination of the Calculation Agent or an Independent Adviser**

Adjustments to the Conversion Price shall be determined and calculated by the Calculation Agent upon request from the Issuer and/or, to the extent so specified in the Conditions and upon request from the Issuer, by an Independent Adviser.

Adjustments to the Conversion Price calculated by the Calculation Agent or, where applicable, an Independent Adviser and any other determinations made by the Calculation Agent or, where applicable, an Independent Adviser, or an opinion of an Independent Adviser, pursuant to these Conditions shall in each case be made in good faith and shall be final and binding (in the absence of manifest error) on the Issuer, the Bondholders and the Calculation Agent (in the case of a determination by an Independent Adviser).

The Calculation Agent may consult, at the expense of the Issuer, on any matter (including, but not limited to, any legal matter), any legal or other professional adviser and it shall be able to rely upon, and it shall not be liable and shall incur no liability as against the Bondholders in respect of anything done, or omitted to be done, relating to that matter in good faith in accordance with that adviser's opinion.

The Calculation Agent shall act solely upon the request from the Issuer, and shall act exclusively as agent of, the Issuer and in accordance with these Conditions. Neither the Calculation Agent (acting in such capacity) nor any Independent Adviser appointed in connection with the Bonds (acting in such capacity) will thereby assume any obligations towards or relationship of agency or trust and shall not be liable and shall incur no liability in respect of anything done, or omitted to be done in good faith, in its capacity as Calculation Agent, or as the case may be, Independent Adviser as against the Bondholders.

If following consultation between the Issuer and the Calculation Agent any doubt shall arise as to whether an adjustment falls to be made to the Conversion Price or as to the appropriate adjustment to the Conversion Price, following consultation between the Issuer and an Independent Adviser, a written opinion of such Independent Adviser in respect thereof shall be conclusive and binding on the Issuer, the Bondholders and the Calculation Agent (if different), save in the case of manifest error.

The Issuer shall promptly notify Bondholders in accordance with Condition 16 (*Notices*) of each determination, calculation or adjustment performed by the Calculation Agent and/or Independent Adviser pursuant to these Conditions.

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**6.6** **Exempt Transactions, Second Tranche Bonds and Concurrent Equity Raise**

Notwithstanding anything to the contrary in these Conditions, but without prejudice to Condition 6.4(a) (*Conversion Price Reset*), no adjustment will be made to the Conversion Price:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) in respect of any Shares issued and allotted pursuant to an Excluded Instrument;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) in respect of the issue of the Second Tranche Bonds (including, for the avoidance of doubt, any further bonds issued in accordance with the terms and conditions thereof) or any Shares issued and allotted pursuant to the exercise of conversion rights or any option similar to the Share Settlement Option under the Second Tranche Bonds; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) in respect of any Shares issued and allotted pursuant to the Concurrent Equity Raise.

**6.7** **Rounding Down and Notice of Adjustment to the Conversion Price**

On any adjustment, the resultant Conversion Price, if not a whole multiple of €0.0001, shall be rounded down to the nearest whole multiple of €0.0001.

Notice of any adjustments to the Conversion Price (and the resulting Minimum PMP) shall be given by the Issuer to Bondholders in accordance with Condition 16 (*Notices*) promptly after the determination thereof.

The Conversion Price shall not in any event be reduced so that, on conversion of the Bonds, Shares would fall to be issued in circumstances not permitted by applicable laws or regulations. The Issuer undertakes that it shall not take any action, and shall procure that no action is taken, that would otherwise result in an adjustment to the Conversion Price that would result in Shares being required to be issued or transferred and delivered in circumstances not permitted by applicable laws or regulations.

**6.8** **Relevant Event**

Within five Qualifying Business Days following the occurrence of a Relevant Event, the Issuer shall give notice thereof to Bondholders in accordance with Condition 16 (*Notices*) (a "**Relevant Event Notice**"). The Relevant Event Notice shall contain a statement informing Bondholders of (i) their entitlement to exercise their Conversion Rights as provided in these Conditions and (ii) their entitlement to exercise their rights to require redemption of their Bonds pursuant to Condition 7.2 (*Redemption at the Option of Bondholders (Relevant Event*). In the case of a Change of Control, the foregoing sentence shall be subject to the Change of Control Resolutions having been approved and filed in accordance with Article 7:151 of the Belgian Companies and Associations Code.

The Relevant Event Notice shall also specify, as applicable:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) if applicable, to the fullest extent permitted by applicable law, all information material to Bondholders concerning the Change of Control;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the nature of the Relevant Event;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) the Conversion Price immediately prior to the occurrence of the Relevant Event and, the Relevant Event Conversion Price applicable pursuant to Condition 6.2(j) (*Relevant Event*) on the basis of the Conversion Price in effect immediately prior to the occurrence of the Relevant Event;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) the Closing Price of the Shares as at the latest practicable date prior to the publication of the Relevant Event Notice;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) the Relevant Event Period; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) the Relevant Event Put Date.

**6.9** **Procedure for exercise of Conversion Rights**

Conversion Rights in respect of a Bond may be exercised by a Bondholder (provided that the relevant Conversion Date falls during the Conversion Period) by (i) in respect of the whole of such Bond, by delivering the relevant Bond Certificate together with a Conversion Notice to the Issuer and (ii) in respect of any Upcoming Amortised Payment Amount, by delivering a Conversion Notice to the Issuer, whereupon the Issuer shall (subject as provided in these Conditions) procure the delivery to, or as directed by, the relevant Bondholder of Shares credited as paid-up in full, as provided in this Condition 6.9 (*Procedure for exercise of Conversion Rights*).

If such delivery is made after 1:00 p.m. Brussels time or on a day which is not a Qualifying Business Day, such delivery shall be deemed for all purposes of these Conditions to have been made on the next following Qualifying Business Day.

The conversion date in respect of a Bond (the "**Conversion Date**") shall be the Qualifying Business Day on which delivery (or deemed delivery) of the relevant Conversion Notice (and, where applicable, the relevant Bond Certificate) is made (or deemed to be made) as provided in this Condition 6.9 (*Procedure for exercise of Conversion Rights*). The Conversion Date shall be deemed to be the date on which the Conversion Right is exercised in respect of such Bond.

A Conversion Notice, once delivered, shall be irrevocable.

Among other things, each Conversion Notice shall specify whether the relevant Bondholder elects for the Shares to be issued or transferred and delivered on exercise of Conversion Rights (including any Additional Shares) to be either US Shares, Belgian Shares or a combination thereof.

Shares to be issued or transferred and delivered on exercise of Conversion Rights (including any Additional Shares) will be issued or transferred and delivered in dematerialised or uncertificated form, as the case may be, through the securities trading system operated by (in the case of Belgian Shares) Euroclear Belgium or (in the case of US Shares) DTC, (as the case may be). Where Shares are to be issued or transferred and delivered through Euroclear Belgium or DTC, they will be delivered to the account specified by the relevant Bondholder in the relevant Payment Details as soon as practicable and in any event by not later than (in the case of Belgian Shares) the second Brussels business day or (in the case of US Shares) the second New York business day, in each case following the relevant Conversion Date (or, in the case of any Additional Shares, not later than the second Brussels or New York business day (as applicable) following the relevant Reference Date). The applicable latest required date for delivery of the Shares or Additional Shares to the relevant Bondholder(s) in respect of any exercise of Conversion Rights, as provided above, shall be the "**Scheduled Delivery Date**" in respect of such Shares or Additional Shares, as the case may be. Shares to be issued or transferred and delivered on exercise of Conversion Rights (including any Additional Shares) shall be delivered to the relevant Bondholder(s) in freely tradeable form under applicable securities laws and will not bear legends noting restrictions as to resale of such securities under US federal or state securities laws nor be subject to stop transfer instructions.

The person or persons specified for such purpose in the Payment Details will become the holder of record of the number of Shares issuable upon conversion with effect from the Registration Date (or, in the case of Additional Shares, the Additional Registration Date). The Issuer shall take all reasonable endeavours to procure such registration of the Shares to be issued as aforesaid as soon

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as practicable and in any event no later than the Scheduled Delivery Date in respect of such Shares or Additional Shares.

The Issuer shall pay all capital, stamp, issue and registration and transfer taxes and duties payable in Belgium, the United States or in any other jurisdiction in which the Issuer may be domiciled or resident or to whose taxing jurisdiction it may be generally subject ("**Specified Taxes**"), in respect of the allotment and issue or transfer and delivery of any Shares to the relevant Bondholder in respect of such exercise of Conversion Rights (including any Additional Shares) or in respect of any allotment and issue or transfer of Bonds. If the Issuer fails to pay any Specified Taxes, the relevant Bondholder shall be entitled to tender and pay the same and the Issuer, as a separate and independent stipulation, covenants to reimburse and indemnify each Bondholder in respect of any payment thereof and any interest and penalties payable and costs incurred in respect thereof.

A Bondholder exercising Conversion Rights must pay directly to the relevant authorities any capital, stamp, issue, registration and transfer taxes and duties arising on the exercise of Conversion Rights (other than any Specified Taxes which shall be payable by the Issuer). A Bondholder must also pay, or procure the payment of all, if any, taxes imposed on it and arising by reference to any disposal or deemed disposal by it of a Bond or interest therein in connection with the exercise of Conversion Rights by it. Any such capital, stamp, issue, registration or transfer taxes or duties or other taxes payable by a Bondholder are referred to as "**Bondholder Taxes**".

For the avoidance of doubt, the Calculation Agent shall not be responsible for determining whether any Specified Taxes or Bondholder Taxes are payable or the amount thereof and shall not be responsible or liable for any failure by the Issuer to pay such Specified Taxes or by a Bondholder to pay such Bondholder Taxes.

Notwithstanding any other provisions of these Conditions, a Bondholder exercising Conversion Rights following a Change of Control Conversion Right Amendment as described in Condition 11(b)(vii) (*Undertakings*) will be deemed, for the purposes of these Conditions, to have received the Shares to be issued upon conversion of the Bonds for the consideration that it would have received therefor if it had exercised its Conversion Right in respect of such Bonds at the time of the occurrence of the relevant Change of Control.

**6.10** **Cash Alternative Election**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Upon exercise of a Conversion Right, and solely in the event and to the extent that the issue and delivery of Shares in respect of such exercise of a Conversion Right would cause the issue, conversion or delivery of (i) more Shares than permitted by applicable law pursuant to Condition 12 (*Regulatory Share Cap*) or (ii) Shares in breach of applicable regulations to deliver freely transferable Shares, the Issuer may make an election (a "**Cash Alternative Election**") by giving notice (a "**Cash Alternative Election Notice**") to the relevant Bondholder by not later than the date (the "**Cash Alternative Election Date**") falling one dealing day after the relevant Conversion Date (with a copy to the Calculation Agent) to satisfy the exercise of the Conversion Right in respect of the relevant Bonds by (i) making payment, or procuring that payment is made, to the relevant Bondholder of the Cash Alternative Amount in respect of the Cash Settled Shares in respect of such exercise as specified in the relevant Cash Alternative Election Notice, and (ii) where the Cash Settled Shares are less than the Reference Shares in respect of the relevant exercise of Conversion Rights, by issuing or transferring and delivering the Physically Settled Shares, together in any such case with any other amount payable to such Bondholder pursuant to these Conditions in respect of or relating to the relevant exercise of Conversion Rights.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) The Cash Alternative Election Notice shall be irrevocable and shall specify:

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the Conversion Price in effect on the relevant Conversion Date and the number of Reference Shares in respect of such exercise of Conversion Rights;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the number of Cash Settled Shares in respect of the relevant exercise of Conversion Rights, by reference to which the Cash Alternative Amount is to be calculated; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) if the number of Cash Settled Shares (determined as aforesaid) is less than the number of Reference Shares in respect of the relevant exercise of Conversion Rights, the number of Physically Settled Shares to be transferred and delivered by the Issuer to the relevant Bondholder in respect of such exercise.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) The Issuer will pay the Cash Alternative Amount not later than the second Brussels business day following the first Brussels business day on which the Cash Alternative Amount is capable of being determined in accordance with these Conditions, by transfer to a bank account in accordance with the Payment Details.

**6.11** **Ranking and Entitlement**

Shares (including any Additional Shares) issued or transferred and delivered on exercise of Conversion Rights will from the date (such date, the "**Registration Date**" or, in the case of Additional Shares, the "**Additional Registration Date**") on which such Shares are registered in a local shareholders' register maintained or kept on behalf of the Issuer, rank *pari passu* with the fully paid Shares in issue on such Registration Date (or, as the case may be, Additional Registration Date), and the person or persons specified for such purpose in the Payment Details by the relevant Bondholder shall be treated as the holder or holders thereof with effect from, and be entitled to all rights, distribution, payments and entitlements (relating to such Shares) the record date or other due date for the establishment of entitlement for which falls on or after, such Registration Date (or, as the case may be, Additional Registration Date), except in any such case for any right excluded by mandatory provisions of applicable law or as otherwise may be provided in these Conditions.

Such Shares or, as the case may be, Additional Shares will not rank for (or, as the case may be, the relevant holder shall not be entitled to receive) any rights, distributions or payments the record date or other due date for the establishment of entitlement for which falls prior to such Registration Date (or, as the case may be, Additional Registration Date).

**6.12** **Interest on Conversion**

No payment or adjustment shall be made on exercise of Conversion Rights for any interest which otherwise would have accrued on the relevant Bonds (or, where Conversion Rights are exercised in respect of any Upcoming Amortised Payment Amount, such Upcoming Amortised Payment Amount) since the last Interest Payment Date preceding the Conversion Date relating to such Bonds (or, if such Conversion Date falls before the first Interest Payment Date, since the Issue Date).

**6.13** **Purchase or Redemption of Shares**

The Issuer or any Subsidiary of the Issuer may exercise such rights as they may from time to time enjoy to purchase or redeem or buy back any shares of the Issuer (including Shares) or any depositary or other receipts or certificates representing the same without the consent of the Bondholders.

**6.14** **No Duty to Monitor**

The Calculation Agent shall not be under any duty to monitor whether any event or circumstance has happened or exists or may happen or exist and which requires or may require an adjustment to

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be made to the Conversion Price or be responsible or liable to any person for any loss arising from any failure by any of them to do so. The Calculation Agent shall also not be responsible or liable to any person (other than in the case of the Calculation Agent, to the Issuer strictly in accordance with the relevant provisions of the Calculation Agency Agreement) for any determination as to whether or not an adjustment to the Conversion Price is required or should be made or for any determination or calculation of any such adjustment.

**6.15** **Consolidated, Amalgamation, Merger, Demerger and Re-domiciliation**

Without prejudice to the restrictions provided in Condition 2.3(c), in the case of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) any consolidation, amalgamation or merger of the Issuer with any other corporation (other than a consolidation, amalgamation or merger in which the Issuer is the continuing corporation); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) a demerger where all or substantially all the assets of the Issuer are transferred to one or more other entities; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) a re-domiciliation where the Issuer is converted to another corporation form in another country than is domicile,

where such entity or entities issue equity shares to Shareholders and *provided, in each case, that* such equity shares benefit from a listing on a stock exchange or multilateral trading facility based in a full member country of the European Union or in the United Kingdom (failing which, the Bondholders shall have such rights as if such failure constituted a Change of Control Conversion Right Amendment), the Issuer will forthwith give notice thereof to the Bondholders in accordance with Condition 16 (*Notices*) of such event and take such steps as shall be required (including the execution of an amendment or supplement to these Conditions) to ensure that each Bond then outstanding will (during the Conversion Period) be convertible into the class and amount of such shares and other Securities receivable upon such consolidation, amalgamation, merger, demerger or re-domiciliation by a holder of the number of Shares which would have become liable to be issued or transferred and delivered upon exercise of Conversion Rights immediately prior to such consolidation, amalgamation, merger, demerger or re-domiciliation.

The above provisions of this Condition 6.15 will apply, *mutatis mutandis*, to any subsequent consolidations, amalgamations, mergers, demergers or re-domiciliations.

**7.** **Redemption of Bonds**

**7.1** **Mandatory Redemption by Amortisation**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) **Scheduled Amortisation Payments** 

Subject to Condition 7.1(c) (*Deferral and Advancement of Amortisation Payments*) below, on each three-month anniversary date of the Concurrent Equity Raise Pricing Date (being 18 February, 18 May, 18 August, and 18 November of each year) (each such date, a "**Scheduled Amortisation Payment Date**", with the first Scheduled Amortisation Payment Date falling on 18 February 2026 and the final Scheduled Amortisation Payment Date falling on the Original Final Maturity Date, and each such date as may become subject to deferral or advancement as provided in Condition 7.1(c) (*Deferral and Advancement of Amortisation Payments*), an "**Amortisation Payment Date**"), each Bond outstanding (except for any Bond in respect of which Conversion Rights have been exercised prior to the relevant Amortisation Payment Date) will be redeemed in instalments of €8,500 per Bond (or, in the case of the instalment scheduled to be redeemed on the Original Final

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Maturity Date, €6,500) (each an "**Amortised Payment Amount**"), together with any interest accrued and unpaid thereon as provided in Condition 5.

Upon each redemption or conversion of an Amortised Payment Amount (including, for the avoidance of doubt, any Advanced Amortised Payment Amount) on an Amortisation Payment Date (including, for the avoidance of doubt, any Advanced Amortisation Payment Date), the principal amount of each Bond shall be reduced accordingly on such Amortisation Payment Date.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) **Principal Share Settlement Option Notice**

In respect of the Amortised Payment Amount (including, for the avoidance of doubt, the Advanced Amortised Payment Amount) due on each Amortisation Payment Date (including, for the avoidance of doubt, any Advanced Amortisation Payment Date), such amount shall be paid in cash at the Cash Amortisation Price in respect of such Amortised Payment Amount unless, subject to Condition 9.9(d) (*Annulment of Share Settlement Option*), the Issuer elects (in its sole discretion) to exercise the Share Settlement Option pursuant to and in accordance with Condition 9.9 in respect of all but not some only of the Bonds by giving notice thereof (a "**Principal Share Settlement Option Notice**") (which notice shall be irrevocable) to Bondholders in accordance with Condition 16 (*Notices*) by no later than 5:00 p.m. New York time on the second Qualifying Business Day prior to such Amortisation Payment Date (or, in the case of any Advanced Amortised Payment Amount due on an Advanced Amortisation Payment Date, by no later than 5:00 p.m. New York time on the second Qualifying Business Day prior to such Advanced Amortisation Payment Date). Shares to be issued or transferred and delivered on exercise of the Share Settlement Option shall be delivered to the relevant Bondholder(s) in freely tradeable form under applicable securities laws and will not bear legends noting restrictions as to resale of such securities under US federal or state securities laws nor be subject to stop transfer instructions.

For the avoidance of doubt, in the event that the Issuer does not deliver a Principal Share Settlement Option Notice on or prior to the dates specified in the preceding paragraph in respect of all Amortised Payment Amount(s) (including, for the avoidance of doubt, any Advanced Amortised Payment Amount) due on the relevant Amortisation Payment Date (including, for the avoidance of doubt, any Advanced Amortisation Payment Date) and in accordance with Condition 16 (*Notices*), each Bondholder may, in its sole discretion, and at any time up to (and including) the Qualifying Business Day immediately preceding the relevant Amortisation Payment Date (including, for the avoidance of doubt, any Advanced Amortisation Payment Date), exercise its Bond Conversion Rights in respect of the whole of a Bond or its Amortisation Conversion Rights in respect of any Upcoming Amortised Payment Amount(s). Any such exercise of Conversion Rights, and the subsequent issue or transfer and delivery of Shares by the Issuer, shall be subject to and completed in accordance with Condition 6 (*Conversion of Bonds*).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) **Deferral and Advancement of Amortisation Payments** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) Subject to paragraph (iii) below, the Majority Bondholders may, on one or more occasions, by giving notice thereof to the Issuer (in or substantially in the form set out in Schedule 7 (*Form of Amortised Payment Advancement Notice and Deferral Notice*) of the Bond Instrument) in accordance with Condition 16 (*Notices*) at least one Brussels business day prior to a Scheduled Amortisation Payment Date, exercise their right to defer any one or more Amortised Payment Amounts (other

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than any Advanced Amortised Payment Amount) that would be payable on such Scheduled Amortisation Payment Date in respect of all or some only of the Bonds outstanding at such time so that such amounts shall not be payable on such Scheduled Amortisation Payment Date and instead shall become payable on any subsequent Scheduled Amortisation Payment Date as specified in such notice (an "**Amortised Payment Deferral**", and any such Amortised Payment Amount so deferred being a "**Deferred Amortised Payment Amount**") (subject always to the rights of the Majority Bondholders under paragraph (ii) below, to subsequently make an Amortised Payment Advancement in respect of such Deferred Amortised Payment Amount), *provided that* in relation to any Amortised Payment Deferral:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) for the purposes of the calculation of the relevant number of Deliverable Shares (if any) which shall be issued or transferred and delivered to the Bondholders in respect of a Share Settlement in accordance with Condition 5.1(b) (*Interest Share Settlement Option Notice*) and/or 7.1(b) (*Principal Share Settlement Option Notice*), if there shall have occurred an event or circumstance requiring an adjustment to the Conversion Price in accordance with Condition 6 (other than Condition 6.4 (*Conversion Price Reset*)) after the relevant SSO Reference Date and if (if the Calculation Agent determines that it is able to make such determination in its capacity as Calculation Agent) the Calculation Agent or (in any other case) an Independent Adviser determines that an adjustment is required to be made to the Relevant Share Settlement Price to give the intended result pursuant to Condition 9.9 (*Share Settlement Option*), such adjustment shall be made as determined by the Calculation Agent or, as the case may be, such Independent Adviser; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) for the avoidance of doubt, interest on any such Deferred Amortised Payment Amount shall accrue to (but excluding) the relevant Scheduled Amortised Payment Date (and be payable on each Interest Payment Date) in accordance with Condition 5.1(a) (*Interest Rate*).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) The Majority Bondholders may, at any time during each Regular Amortisation Period, by giving notice to the Issuer in accordance with Condition 16 (*Notices*) (each such notice being in or substantially in the form set out in Schedule 7 (*Form of Amortised Payment Advancement Notice and Deferral Notice*) of the Bond Instrument, an "**Amortised Payment Advancement Notice** "), exercise their right to bring forward (at the Majority Bondholders' discretion) up to two payments of the Amortised Payment Amount (or, if more than one Amortised Payment Amount is due on any Advanceable Amortisation Date in respect of such Amortised Payment Advancement Notice, up to two such Amortised Payment Amounts (at the Majority Bondholders' discretion)) in respect of all or some only of the Bonds outstanding at such time as would otherwise be scheduled (as at the date on which the Amortised Payment Advancement Notice is given (or deemed to be given pursuant to sub-paragraph (B) below)) to be paid in respect of such Bond(s) (for the avoidance of doubt, which Amortised Payment Amount may include any Amortised Payment Amount which has been subject to an Amortised Payment Deferral) either (x) on the Final Maturity Date or (y) on each of the Final Maturity Date and the immediately preceding Amortisation Payment Date (each, an "**Advanceable Amortisation Date**" in respect of such Amortised Payment Advancement Notice) (with the first such Amortised Payment Advancement (if any) in respect of any Bond being therefore in respect of the Amortised Payment

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Amount(s) which would otherwise be due either on the Original Final Maturity Date or on each of the Original Final Maturity Date and the Scheduled Amortisation Payment Date immediately preceding the Original Final Maturity Date) (any such Amortised Payment Amount so brought forward, an "**Advanced Amortised Payment Amount**") in which case such payments shall become payable on the date specified in such notice (the Amortisation Payment Date in respect of such Advanced Amortised Payment Amount(s), an "**Advanced Amortisation Payment Date**", which shall not be earlier than the third Brussels business day following the date on which the relevant Amortised Payment Advancement Notice is given (or deemed to be given pursuant to sub-paragraph (B) below)) (an "**Amortised Payment Advancement**"), and *further provided that* in relation to any Amortised Payment Advancement:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) for the purposes of the calculation of the relevant number of Deliverable Shares (if any) which shall be issued or transferred and delivered to the Bondholders following any exercise of the Share Settlement Option in accordance with Condition 5.1(b) (*Interest Share Settlement Option Notice*) and/or 7.1(b) (*Principal Share Settlement Option Notice*), if there shall have occurred an event or circumstance requiring an adjustment to the Conversion Price in accordance with Condition 6 (other than Condition 6.4 (*Conversion Price Reset*) after the relevant SSO Reference Date and if (if the Calculation Agent determines that it is able to make such determination in its capacity as Calculation Agent) the Calculation Agent or (in any other case) an Independent Adviser determines that an adjustment is required to be made to the Relevant Share Settlement Price to give the intended result pursuant to Condition 9.9 (*Share Settlement Option*), such adjustment shall be made as determined by the Calculation Agent or, as the case may be, such Independent Adviser;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) if the delivery of the relevant Amortised Payment Advancement Notice is made after 1:00 p.m. Brussels time or on a day which is not a Qualifying Business Day, such Amortised Payment Advancement Notice shall be deemed for all purposes of these Conditions to have been given on the next following Qualifying Business Day (and, for the avoidance of doubt, the relevant Advanced Amortised Payment Date shall not be earlier than the second Brussels business day following the date on which such Amortised Payment Advancement Notice is deemed to have been given);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(C) in respect of each Regular Amortisation Period, the option to require an Amortised Payment Advancement may be exercised (I) if each Amortised Payment Advancement Notice given (or deemed to be given pursuant to sub-paragraph (B) above) during such Regular Amortisation Period is in relation to Amortised Payment Amount(s) otherwise scheduled to be paid on only one Advanceable Amortisation Date, then no more than twice during such Regular Amortisation Period, or (II) if the relevant Amortised Payment Advancement Notice given (or deemed to be given pursuant to sub-paragraph (B) above) during such Regular Amortisation Period is in relation to Amortised Payment Amount(s) otherwise scheduled to be paid on two Advanceable Amortisation Dates, then only once during such Regular Amortisation Period;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(D) any Amortised Payment Advancement in respect of any Amortised Payment Amount that has previously been subject to an Amortised Payment Deferral shall not be counted for the purposes of the limitations set out in paragraph (C) above;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(E) amongst other things, each Amortised Payment Advancement Notice shall specify whether the Majority Bondholders elect for the Shares to be issued or transferred and delivered upon exercise (if any) of the Share Settlement Option in respect of the relevant Advanced Amortised Payment Amount and/or interest accrued and unpaid thereon to be either US Shares, Belgian Shares or a combination thereof; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(F) for the avoidance of doubt, interest accrued and unpaid on any such Advanced Amortised Payment Amount shall be the interest accrued and unpaid thereon to (but excluding) the relevant Advanced Amortisation Payment Date and, for the avoidance of doubt, any such interest amount shall be payable on such Advanced Amortisation Payment Date.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) Nothing in this Condition 7.1(c) shall affect the rights of the Bondholders to exercise Conversion Rights in respect of any Bonds.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) **No Other Early Redemption** 

Unless previously redeemed or converted as herein provided, the Bonds will be redeemed at their remaining principal amount on the Final Maturity Date. The Bonds may only be redeemed earlier than as contemplated in this Condition 7.1 if at the option of the Bondholders in accordance with Condition 7.2 (*Redemption at the Option of Bondholders (Relevant Event*)).

**7.2** **Redemption at the Option of Bondholders (Relevant Event)**

Following the occurrence of a Relevant Event, each Bondholder will have the right to require the Issuer to redeem, in cash (but without prejudice to the rights of Bondholders to require the Issuer to issue or transfer and deliver Shares as provided below), such Bond on the Relevant Event Put Date at the relevant Early Redemption Amount. To exercise such right, the holder of the relevant Bond must give notice thereof to the Issuer in accordance with Condition 16 (*Notices*) and deliver the relevant Bond Certificate to the Issuer at any time during the Relevant Event Period.

The "**Relevant Event Put Date**" shall be the second Brussels business day after the expiry of the Relevant Event Period.

Subject to the final paragraph below, payment in respect of any such Bond shall be made in accordance with Condition 8 (*Taxation*).

Any notice given by a Bondholder to exercise its put right pursuant to this Condition 7.2, once delivered, shall be irrevocable and the Issuer shall redeem all Bonds the subject of such notices delivered as aforesaid on the Relevant Event Put Date.

Any such notice may, in the sole discretion of the relevant Bondholder, specify that such Bondholder elects to receive Belgian Shares, US Shares or a combination thereof in lieu of being paid in cash the relevant Early Redemption Amount, in which case the Issuer shall issue or transfer and deliver Shares as if the Share Settlement Option had been exercised in respect of such amounts

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due and on the basis that Condition 9.9 (*Share Settlement*) applied, *mutatis mutandis*, assuming for this purpose that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the SSO Reference Date is the relevant Put SSO Reference Date,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the Amortised Payment Amount in respect of which the Share Settlement Option is exercised is such Early Redemption Amount,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) the interest amount (if any) in respect of which the Share Settlement Option is exercised is the accrued and unpaid interest (if any) up to (but excluding) the Relevant Event Put Date,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) the Scheduled SSO Delivery Date is (in the case of Belgian Shares) the second Brussels business day or (in the case of US Shares) the second New York business day, in each case following the first Brussels business day on which such Early Redemption Amount is capable of being determined in accordance with these Conditions;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) paragraphs (iii), (iv), (v) and (vi) of the definition of Share Settlement Liquidity Event shall not apply.

This Condition 7.2 will only become effective if and when the Change of Control Resolutions are approved and filed with the clerk's office of the competent Enterprise Court in accordance with the provisions of the Belgian Companies and Associations Code.

**7.3** **Redemption if the Change of Control Resolutions are not passed**

If the Change of Control Resolutions are not, on or before the Longstop Date (a) adopted at a general meeting of the Shareholders of the Issuer, and (b) filed with the clerk's office at the competent Enterprise Court in accordance with the provisions of the Belgian Companies and Associations Code, each Bondholder will have the right to require the Issuer to redeem in cash (but without prejudice to the rights of Bondholders to require the Issuer to issue or transfer and deliver Shares as provided below) each Bond, on the date falling 30 days after the Longstop Date at the Early Redemption Amount. The Issuer shall notify each Bondholder in accordance with Condition 16 (*Notices*) promptly upon becoming aware that it has not satisfied the requirements set out in (a) or (b) above.

Each Bondholder may, in its sole discretion, notify the Issuer in writing that such Bondholder elects to receive Belgian Shares, US Shares or a combination thereof in lieu of being paid in cash the relevant Early Redemption Amount, in which case the Issuer shall issue or transfer and deliver Shares as if the Share Settlement Option had been exercised in respect of such amounts due and on the basis that Condition 9.9 (*Share Settlement*) applied, *mutatis mutandis*, assuming for this purpose that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the SSO Reference Date is the relevant Put SSO Reference Date,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the Amortised Payment Amount in respect of which the Share Settlement Option is exercised is such Early Redemption Amount,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) the interest amount (if any) in respect of which the Share Settlement Option is exercised is the accrued and unpaid interest (if any) up to (but excluding) the Relevant Event Put Date,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) the Scheduled SSO Delivery Date is (in the case of Belgian Shares) the second Brussels business day or (in the case of US Shares) the second New York business day, in each case following the first Brussels business day on which such Early Redemption Amount is capable of being determined in accordance with these Conditions;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) paragraphs (iii), (iv), (v) and (vi) of the definition of Share Settlement Liquidity Event shall not apply.

**7.4** **No Other Redemption**

The Issuer shall not be entitled to redeem or purchase the Bonds otherwise than as provided in this Condition 7 (*Redemption of Bonds*).

**7.5** **Cancellation**

All Bonds which are redeemed or in respect of which Bond Conversion Rights are exercised will be cancelled and may not be reissued or re-sold.

**8.** **Taxation**

All payments in respect of the Bonds (including, for the avoidance of doubt, any Cash Alternative Amount as well as the attribution of interest in connection with the Share Settlement Option) will be made free and clear of, and be made without deduction or withholding for, or on account of any present or future taxes, duties, assessments or governmental charges of whatever nature imposed, levied, collected, withheld or assessed by, or on behalf of, any tax jurisdiction applicable to the Issuer (including Belgium) or any political subdivision or any authority thereof or therein having power to tax (or any other jurisdiction in which the Issuer may be domiciled or resident or to whose taxing jurisdiction it may be generally subject) (each a "**Tax Jurisdiction**"), unless deduction or withholding of such taxes, duties, assessments or governmental charges is required to be made by law (a "**Tax Withholding**"). In that event, the Issuer will pay such additional amounts as will result in the receipt by the Bondholders of such amounts as would have been received by them if no such Tax Withholding been required, except that no such additional amount shall be payable in relation to any payment in respect of any Bond:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) to a Bondholder (or to a third party on behalf of a Bondholder) who is liable to such taxes, duties, assessments or governmental charges in respect of such Bond by reason of that Bondholder having some connection with a Tax Jurisdiction otherwise than merely by holding the Bond or by the receipt of amounts in respect of the Bond; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) where the Bondholder would have been able lawfully to avoid (but has not so avoided) such withholding or deduction by complying with any statutory requirement or by making a declaration of non-residence or any other claim for exemption to any tax authority, in each case following a reasonable request by the Issuer, or by providing the Issuer with a duly completed and signed Tax Status Certificate as provided in Schedule 9 of the Original Bond Instrument (*Form of Tax Status Certificate*), in each case following a written request by the Issuer at least 15 days before each Interest Payment Date.

Notwithstanding any other provision of these Conditions, any amounts to be paid on the Bonds by or on behalf of the Issuer will be paid net of any deduction or withholding imposed or required pursuant to an agreement described in Section 1471(b) of the U.S. Internal Revenue Code of 1986, as amended (the "Code"), or otherwise imposed pursuant to sections 1471 through 1474 of the Code (or any regulations thereunder or official interpretations thereof) or an intergovernmental agreement between the United States and another jurisdiction facilitating the implementation thereof (or any fiscal or regulatory legislation, rules or practices implementing such an intergovernmental agreement) (any such withholding or deduction, a "**FATCA Withholding**"). Neither the Issuer nor any other person will be required to pay any additional amounts or otherwise indemnify a Bondholder in respect of FATCA Withholding.

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References in these Conditions to principal and/or interest and/or any other amounts payable in respect of the Bonds shall be deemed also to refer to any additional amounts which may be payable under this Condition.

**9.** **Payments**

**9.1** **Principal and Interest**

Payment of principal and interest in respect of the Bonds pursuant to these Conditions (and delivery in lieu thereof of any Shares pursuant to any exercise of the Share Settlement Option, as applicable) will be made to, or to the order of, and in accordance with the Payment Details provided by, the persons shown in the Register (as defined in the Bond Instrument) at the close of business on the Record Date.

**9.2** **Other Amounts**

Payments of all amounts other than as provided in Condition 9.1 (*Principal and interest*) will be made as provided in these Conditions.

**9.3** **Record Date**

For the purposes of these Conditions, "**Record Date**" means the Brussels business day before the due date for the relevant payment of principal or interest (disregarding for this purpose any exercise of the Share Settlement Option or Conversion Rights in respect thereof).

**9.4** **Payments**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Each cash payment in respect of Bonds pursuant to Conditions 9.1 (*Principal and interest*) and 9.2 (*Other amounts*) will, with respect to each relevant Bondholder, be made by transfer to a bank account in accordance with the relevant Payment Details.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) The Issuer shall initiate, or shall procure the initiation of, cash payment instructions for value as of the due date, or, if the due date is not a Brussels business day, for value the next succeeding Brussels business day.

**9.5** **Delay in Payment**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Bondholders will not be entitled to any interest or other payment for any delay after the due date in receiving the cash amount due to be paid or, as the case may be, the Shares due to be delivered:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) as a result of the due date not being a business day in Brussels or in the city in which the recipient account is based; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) as a result of the relevant Bondholder failing to provide fulsome and correct Payment Details.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) If any date for payment in respect of any Bond is not a Brussels business day, each Bondholder shall not be entitled to payment until the next following Brussels business day.

**9.6** **Calculation Agent**

The Issuer reserves the right, subject to the prior approval of the Majority Bondholders after being given not less than 20 London business days' notice under the Calculation Agency Agreement at any time to vary or terminate the appointment of the Calculation Agent and appoint another Calculation Agent, provided that they will maintain a Calculation Agent which shall be a financial

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institution of international repute or an independent financial adviser with appropriate expertise. The Issuer shall promptly notify the Bondholders of any such proposal of a variation, termination or appointment.

**9.7** **No Charges**

Neither the Issuer nor any person or agent acting on its behalf shall make or impose on a Bondholder any charge or commission in relation to any payment, transfer or conversion in respect of the Bonds including any issue or delivery of Shares pursuant to the exercise of any Share Settlement Option.

**9.8** **Fractions**

When making payments to Bondholders, if the relevant payment is not of an amount which is a whole multiple of the smallest unit of the relevant currency in which such payment is to be made, such payment will be rounded down to the nearest unit.

**9.9** **Share Settlement Option**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) **Exercise of Share Settlement Option** 

If:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) an Interest Share Settlement Option Notice is given by the Issuer in accordance with Condition 5.1(b) (*Interest Share Settlement Option Notice*); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) a Principal Share Settlement Option Notice is given by the Issuer in accordance with Condition 7.1(b) (*Principal Share Settlement Option Notice*),

as applicable, the Issuer's obligation to pay cash interest on each Bond on the relevant Interest Payment Date pursuant to Condition 5.1(a) (*Interest Rate*) or on any Advanced Amortisation Payment Date or to redeem in cash a principal amount of the Bonds in an Amortised Payment Amount on the relevant Amortisation Payment Date (including, for the avoidance of doubt, any Advanced Amortisation Payment Date) pursuant to Condition 7.1(a) (*Scheduled Amortisation Payments*) shall, subject to Condition 9.9(d) (*Annulment of Share Settlement Option*), be satisfied by the issue or transfer and delivery (and, without prejudice to any of the provisions of these Conditions, which Shares shall be paid up in full by contribution in kind by the relevant Bondholder of its receivable on the Issuer for payment of the relevant amounts due under the Bonds) against issuance to the relevant Bondholder of the relevant number of Deliverable Shares (the "**Share Settlement Option**" in respect of the relevant Interest Payment Date or Amortisation Payment Date, as applicable) with respect to all but not some only of the Bonds as soon as practicable and in any event not later than the applicable Scheduled SSO Delivery Date.

Notwithstanding the Issuer's option (in its sole discretion) to exercise any Share Settlement Option pursuant to and in accordance with these Conditions, the Issuer shall be deemed to be required to exercise a Share Settlement Option in respect of any payment of interest or principal amounts under the Bonds where the Issuer is in possession of Restricted Information in relation to the Shares at the time of such payment, except if the Issuer is restricted by applicable laws or regulations from issuing or transferring and delivering Shares in accordance with these Conditions in which case it shall make any such payment in cash.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) **Share Settlement** 

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Where the Share Settlement Option has been validly exercised, subject to Condition 9.9(d) (*Annulment of Share Settlement Option*) and without prejudice to Condition 8 (*Taxation*) which shall apply to Condition 9.9(b)(i) and Condition 9.9(b)(ii) below:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) in lieu of the payment in cash by the Issuer in respect of interest on the relevant Interest Payment Date (other than in respect of an Advanced Amortised Payment Amount) or, as the case may be, in respect of any Amortised Payment Amount (other than an Advanced Amortised Payment Amount) on the relevant Scheduled Amortisation Payment Date, as applicable, the Issuer shall organise an increase of its capital and the Bondholders shall subscribe to such capital increase by way of contribution in kind by the Bondholders of their receivable on the Issuer for such payment of the accrued interest and/or Amortised Payment Amount against issuance of the Deliverable Shares to the Bondholders as soon as practicable and in any event not later than (in the case of Belgian Shares) the second Brussels business day or (in the case of US Shares) the second New York business day, in each case, following such Interest Payment Date or Scheduled Amortisation Payment Date, as the case may be.

For the avoidance of doubt, any Deliverable Shares issued in accordance with this Condition 9.9(b)(i) shall be fully paid-up; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) in lieu of the payment in cash in respect of interest or, as the case may be, in respect of an Advanced Amortised Payment Amount, in each case on an Advanced Amortisation Payment Date, the Issuer shall organise an increase of its capital and the Bondholders shall subscribe to such capital increase by way of contribution in kind by the Bondholders of their receivable on the Issuer for such payment of the accrued interest and/or Advanced Amortised Payment Amount against issuance of the Deliverable Shares to the Bondholders as soon as practicable and in any event not later than:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) such Advanced Amortisation Payment Date; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) (if any of the Deliverable Shares are US Shares, and in any such case in the case of such US Shares only) if later, the date falling three New York business days following the date (or, as applicable pursuant to these Conditions, deemed date) of delivery of the Amortised Payment Advancement Notice.

For the avoidance of doubt, any Deliverable Shares issued in accordance with this Condition 9.9(b)(ii) shall be fully paid-up;

(each of (i) and/or (ii), a "**Share Settlement**"). The applicable latest required date for delivery of the Deliverable Shares to Bondholders, as provided above, shall be the "**Scheduled SSO Delivery Date**" in respect thereof, *provided that*, (A) where proviso (i) or (ii) to the definition of "Reference Lowest Daily Market Price" applies to the Reference Lowest Daily Market Price required for the determination of the number of Deliverable Shares, the Scheduled SSO Delivery Date in respect thereof shall be the later of (1) the date determined as aforesaid and (2) the first date on which the adjusted Conversion Price referred to in proviso (i) or (ii) of such definition as aforesaid is capable of being determined in accordance with Condition 6.2 (*Adjustment of Conversion Price*), and (B) where the relevant Bondholder fails to give the Belgian/US Share Confirmation by the specified deadline as contemplated in Condition 9.9(e)(vi)(B), the Scheduled SSO Delivery Date shall be the later of (i) the date determined as provided above and (ii) (in the

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case of Belgian Shares) two Brussels business days or (in the case of US Shares) two New York business days, in each case following the date on which the Belgian/US Share Confirmation is given (or, as applicable pursuant to these Conditions, deemed to be given).

Fractions of Shares will not be issued or transferred or delivered pursuant to this Condition 9.9 and no cash payment or other adjustment will be made in lieu thereof. However, to the extent that the Shares to be issued and/or transferred and delivered pursuant to this Condition 9.9 (*Share Settlement Option*) are to be registered in the same name, the number of Shares to be issued and/or transferred and delivered in respect thereof shall be calculated on the basis of the aggregate principal amount of such Bonds, as determined by the Calculation Agent.

Promptly following the determination of the Relevant Share Settlement Price and the number of Deliverable Shares, the Issuer shall give notice thereof to the Bondholders in accordance with Condition 16 (*Notices*).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) **Certain Definitions** 

For the purposes of these Conditions:

"**Deliverable Shares**" means, in respect of any Bondholder and any interest amount payable on Interest Payment Date (or, as the case may be, Advanced Amortisation Payment Date) or principal amount of the Bonds redeemable on an Amortisation Payment Date (including, for the avoidance of doubt, any Advanced Amortisation Payment Date), in each case which would otherwise be payable in cash, such number of Shares determined by the Calculation Agent by dividing the relevant interest amount in respect of such Bonds on such Interest Payment Date (or, as the case may be, Advanced Amortisation Payment Date) or the relevant Amortised Payment Amount in respect of such Bond on such Amortisation Payment Date, as applicable, by the Relevant Share Settlement Price in respect of such Interest Payment Date or Amortisation Payment Date (as applicable), subject to Condition 7.1(c)(i)(A) (*Deferral and Advancement of Amortisation Payments*) and Condition 7.1(c)(ii)(A) (*Deferral and Advancement of Amortisation Payments*).

"**Offer Period**" means any period commencing on the date of first public announcement of an offer or tender (howsoever described) by any person or persons in respect of all or a majority of the issued and outstanding Shares and ending on the date that offer or tender ceases to be open for acceptance or, if earlier, on which that offer or tender lapses or terminates or is withdrawn.

"**Reference Lowest Daily Market Price**" means, in respect of any SSO Reference Date, such price (rounded to the nearest whole multiple of €0.0001 (with €0.00005 being rounded upwards)) as is equal to (x) the lower of (i) the Volume Weighted Average Price of a Share (translated if necessary into EUR at the Prevailing Rate) on such SSO Reference Date and (ii) the lowest of the five Volume Weighted Average Prices of a Share (translated if necessary into EUR at the Prevailing Rate) on each of the five consecutive dealing days ending on (but excluding) such SSO Reference Date, or (y) if such SSO Reference Date is not a dealing day, such price as is determined pursuant to (x)(ii) above, in each case *provided that*:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) if any such dealing day falls on or after the Applicable Adjustment Reference Date in respect of any event giving rise to an adjustment to the Conversion Price pursuant to Condition 6.2 (*Adjustment of Conversion Price*) and the relevant SSO Registration Date falls on or before the Applicable Adjustment Record Date in

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respect of such event, then the Volume Weighted Average Price of a Share on such dealing day shall be multiplied by a fraction, (x) the numerator of which is the Conversion Price in effect immediately prior to such adjustment, and (y) the denominator of which is the Conversion Price so adjusted;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) if any such dealing day falls before the Applicable Adjustment Reference Date in respect of any event giving rise to an adjustment to the Conversion Price pursuant to Condition 6.2 (*Adjustment of Conversion Price*) and the relevant SSO Registration Date falls after the Applicable Adjustment Record Date in respect of such event, then the Volume Weighted Average Price on such dealing day shall be multiplied by a fraction, (x) the numerator of which is the Conversion Price so adjusted, and (y) the denominator of which is the Conversion Price in effect immediately prior to such adjustment;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) if such SSO Reference Date is the Issue Date, the Reference Lowest Daily Market Price in respect of such date shall be €4.00; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) if any doubt shall arise as to the appropriate calculation of the Reference Lowest Daily Market Price, or if the Reference Lowest Daily Market Price cannot be determined as provided above, the Reference Lowest Daily Market Price shall be equal to such price as is determined in such other manner as an Independent Adviser shall consider to be appropriate to give the intended result.

"**Relevant Share Settlement Price**" means in respect of any SSO Reference Date, the lower of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) the Conversion Price in effect on the relevant Scheduled Amortisation Payment Date, or as the case may be, Interest Payment Date in relation to which the Share Settlement Option is exercised (or, if such date falls on an Advanced Amortisation Payment Date, the Conversion Price in effect on the date falling two Qualifying Business Days prior to such Advanced Amortisation Payment Date); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) the product (rounded to the nearest whole multiple of €0.0001 (with €0.00005 being rounded upwards)) of (x) 90 per cent. and (y) the Reference Lowest Daily Market Price in respect of such SSO Reference Date,

as determined by the Calculation Agent.

"**SSO Reference Date**" means, in respect of any Share Settlement, the relevant Interest Payment Date or Amortisation Payment Date in respect of which the Share Settlement Option is exercised, *provided that*:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) in the case of Share Settlement of any Deferred Amortised Payment Amount, (except as provided in (ii) below) the SSO Reference Date shall be the originally Scheduled Amortisation Payment Date in respect of such deferred Amortised Payment Amount; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) in the case of Share Settlement of any Amortised Payment Amount which is subject to an Amortised Payment Advancement (including, for the avoidance of doubt, any Amortised Payment Amount which was previously subject to an Amortised Payment Deferral), the SSO Reference Date shall be whichever date

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determined pursuant to (A) or (B) below results in the lowest Reference Lowest Daily Market Price in respect of such date:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) the Scheduled Amortisation Payment Date immediately preceding the date on which the relevant Amortised Payment Advancement Notice was given (or deemed to be given pursuant to Condition 7.1(c)(ii)(B) (*Deferral and Advancement of Amortisation Payments*); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) the Scheduled Amortisation Payment Date immediately preceding the date determined in accordance with (A) above (or, if there is no such Amortisation Payment Date, the SSO Reference Date shall be the Issue Date).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) **Annulment of Share Settlement Option** 

If the relevant Share Settlement Option is exercised but a Share Settlement Liquidity Event occurs prior to registration of the Shares in respect of such exercise of the Share Settlement Option, then such Share Settlement shall be invalid and annulled and the relevant interest amount or Amortised Payment Amount shall be paid in cash in accordance with the relevant provisions of Condition 5.1 (*Interest Rate*) or Condition 7.1 (*Mandatory Redemption by Amortisation*), as applicable, and payment in respect thereof shall be made in accordance with Conditions 9.1 (*Principal and interest*) to 9.8 (*Fractions*). Any Amortised Payment Amounts that are subject to cash payment shall be payable at the Cash Amortisation Price in respect thereof specified in Condition 7.1(b) (*Principal Share Settlement Option Notice*).

Notwithstanding anything to the contrary in these Conditions, where any exercise of the Share Settlement Option is deemed to be invalid and annulled as aforesaid, the relevant interest payment and/or Amortised Payment Amount shall be made in cash:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) on the relevant Interest Payment Date or Scheduled Amortisation Payment Date (or, as the case may be, Advanced Amortisation Payment Date); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) if the relevant Share Settlement Liquidity Event first occurred on or after the Brussels business day falling immediately prior to the relevant Interest Payment Date or Scheduled Amortisation Payment Date (or, as the case may be, Advanced Amortisation Payment Date), on the second Brussels business day following the date on which such Share Settlement Liquidity Event occurs,

*provided that* where paragraph (ii) applies the amount of interest and/or principal payable shall be such amount(s) as would have been payable on the relevant Interest Payment Date or Scheduled Amortisation Payment Date (or, as the case may be, Advanced Amortisation Payment Date) and Bondholders will not be entitled to any interest or other payment for such delay in receiving such interest and/or principal amount(s) as a result of the relevant exercise of the Share Settlement Option being deemed to be invalid and annulled as aforesaid.

For the purposes of these Conditions:

"**Daily Traded Value**" means:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) (for the purposes of determining any Share Average DTV) on any Qualifying Stock Exchange Day, the aggregate daily traded value (if any) of the Shares on (x) the Relevant Stock Exchange in respect thereof and (y) (if the Shares are listed and

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admitted to trading on any of the US Markets) such US Market(s), in each case, on such Qualifying Stock Exchange Day as published on Bloomberg page HP (or any successor Bloomberg ticker or page) in respect of the Shares and such Relevant Stock Exchange and (if any) US Market(s) (such pages being as at the Issue Date, for the avoidance of doubt, NYXH BB Equity HP and NYXH US Equity HP respectively) (using the setting labelled "PR093 Turnover / Traded Value", or any successor setting), in each case translated if necessary into EUR at the Prevailing Rate on such Qualifying Stock Exchange Day, all as determined by the Calculation Agent as at the Bloomberg Screen Observation Time in respect of such Qualifying Stock Exchange Day, or, if the Daily Traded Value is not capable of being so determined, as determined by an Independent Adviser;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) (for the purposes of determining any Relevant Stock Exchange) on any day on which the relevant stock exchange or securities market on which the Shares, other Securities, Spin-Off Securities, options, warrants or other rights or assets are listed and admitted to trading is open for business (other than any day on which such trading is scheduled to close prior to its regular weekday closing time), the aggregate daily traded value (if any) of the Shares, other Securities, Spin-Off Securities, options, warrants or other rights or assets, as the case may be, on such stock exchange or securities market on such day as published on Bloomberg page HP (or any successor Bloomberg ticker or page) in respect of the Shares, other Securities, Spin-Off Securities, options, warrants or other rights or assets, as the case may be, and such stock exchange or securities market (using the setting labelled "PR093 Turnover / Traded Value", or any successor setting), translated if necessary into EUR at the Prevailing Rate on such day, all as determined by the Calculation Agent as at the Bloomberg Screen Observation Time in respect of such day, or, if the Daily Traded Value is not capable of being so determined, as determined by an Independent Adviser.

"**Minimum PMP**" in effect on any date means initially €1.25, subject to adjustment with effect from (and including) any Applicable Adjustment Reference Date in respect of any event giving rise to an adjustment to the Conversion Price pursuant to Condition 6.2 (*Adjustment of Conversion Price*), the Minimum PMP so adjusted being equal to the product (rounded to the nearest whole multiple of €0.0001 (with €0.00005 being rounded upwards)) of (i) the Minimum PMP in effect immediately prior to such adjustment and (ii) a fraction, (x) the numerator of which is the Conversion Price so adjusted, and (y) the denominator of which is the Conversion Price in effect immediately prior to such adjustment.

"**Prevailing Market Price**" means, on any date falling in a Share Settlement Liquidity Period, the arithmetic mean (rounded to the nearest whole multiple of €0.0001 (with €0.00005 being rounded upwards)) of the Volume Weighted Average Prices (translated if necessary into EUR at the Prevailing Rate) on each dealing day comprised in the period of five consecutive dealing days ending on (and including) the dealing day immediately preceding such date, provided that where (i) the Applicable Adjustment Reference Date in respect of any event giving rise to an adjustment to the Conversion Price pursuant to Condition 6.2 (*Adjustment of Conversion Price*) falls on or prior to the last day of such Share Settlement Liquidity Period, and (ii) any such dealing day falls prior to such Applicable Adjustment Reference Date, the Volume Weighted Average Price of a Share on such dealing day shall be multiplied by a fraction, (x) the numerator of which is the Conversion Price so adjusted, and (y) the denominator of which is the Conversion Price in effect immediately prior to such adjustment.

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"**Share Average DTV**" means, in respect of any Share Settlement Liquidity Period, the arithmetic mean (rounded to the nearest whole multiple of €1.00 (with €0.50 being rounded upwards)) of the Daily Traded Values on each Qualifying Stock Exchange Day comprised in such Share Settlement Liquidity Period.

A "**Share Settlement Liquidity Event**" shall have occurred in respect of any exercise of the Share Settlement Option if one or more of the following conditions is met (and, other than in the case of paragraph (vii) below, is not waived by the Majority Bondholders in writing):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) on any date falling in the relevant Share Settlement Liquidity Period, the Shares are not (1) listed and admitted to trading on the Relevant Stock Exchange as at such date, or are suspended from trading on such market (provided that trading of the Shares shall not be considered to be suspended on any day on which a general suspension of trading on such market has occurred) on such date, or (2) a participating security in Euroclear Belgium or DTC (as applicable) on such date;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) an Event of Default or Potential Event of Default shall have occurred and be continuing as at any date falling in the relevant Share Settlement Liquidity Period;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) a Share Settlement Free Float Event shall have occurred on any date falling in the relevant Share Settlement Liquidity Period;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) the Share Average DTV in respect of the relevant Share Settlement Liquidity Period is less than €350,000;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) the Prevailing Market Price of a Share on any dealing day falling in the relevant Share Settlement Liquidity Period is less than the Minimum PMP in effect on the last day of such Share Settlement Liquidity Period;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) an Offer Period (as defined below) shall be continuing as at any date falling in the relevant Share Settlement Liquidity Period; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) the Issuer is notified in writing no later than the last day of the relevant Share Settlement Liquidity Period by any Bondholder in accordance with Condition 16 (*Notices*) that the exercise of the relevant Share Settlement Option would result in such Bondholder acquiring (alone or in concert) more than 9.99 per cent. of the voting rights in the share capital of the Issuer.

"**Share Settlement Liquidity Period**" means, in respect of any exercise of the Share Settlement Option:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) (for the purpose of limbs (i), (ii), (iii), (vi) and (vii) of the definition of "Share Settlement Liquidity Event") the period from (and including) the Interest Payment Date immediately preceding the relevant SSO Reference Date (or, in the case of any interest or an Advanced Amortised Payment Amount due on an Advanced Amortisation Payment Date, the Interest Payment Date immediately preceding the relevant Advanced Amortisation Payment Date) (or, if none, from (and including) the Issue Date) to (and including) the date immediately preceding the date on which the Deliverable Shares are issued or transferred and delivered to Bondholders; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) (for the purpose of limbs (iv) and (v) of the definition of "Share Settlement Liquidity Event") the period from (and including) the Interest Payment Date

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immediately preceding the relevant SSO Reference Date (or, in the case of any interest or an Advanced Amortised Payment Amount due on an Advanced Amortisation Payment Date, the Interest Payment Date immediately preceding the relevant Advanced Amortisation Payment Date) (or, if none, from (and including) the Issue Date) to (and including) the second dealing day prior to the SSO Reference Date (or, in the case of any interest or an Advanced Amortised Payment Amount due on an Advanced Amortisation Payment Date, the relevant Advanced Amortisation Payment Date).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) **Provisions relating to the Share Settlement Option** 

The following provisions shall apply in respect of an exercise of a Share Settlement Option:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) Shares issued and/or transferred and delivered (and, without prejudice to any of the provisions of these Conditions, which Shares shall be paid up in full by setting off the Issuer's debt to pay relevant amounts due under the Bonds) pursuant to this Condition 9.9 (*Share Settlement Option*) will from the date (such date (which shall apply to all Deliverable Shares (whether comprising Belgian Shares and/or US Shares)) in respect of the relevant Bondholder and interest amount and/or principal amount in respect of which the Share Settlement Option was exercised), the "**SSO Registration Date**") on which such Shares are registered in a local shareholders' register maintained or kept on behalf of the Issuer, rank *pari passu* with the fully paid Shares in issue on such SSO Registration Date and the person or persons specified for such purpose in the Payment Details by the relevant Bondholder shall be treated as the holder or holders thereof with effect from, and be entitled to all rights, distribution, payments and entitlements (relating to such Shares) in respect of which the record date or other due date for the establishment of entitlement in respect of the Shares for which falls on or after, such SSO Registration Date, except in any such case for any right excluded by mandatory provisions of applicable law or as otherwise may be provided in these Conditions. Such Deliverable Shares will not rank for (or, as the case may be, the relevant holder shall not be entitled to receive) any rights, distributions or payments the record date or other due date for the establishment of entitlement for which falls prior to such SSO Registration Date.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) The Issuer shall pay all Specified Taxes in respect of the issue or transfer and delivery of any Deliverable Shares to the relevant Bondholder. If the Issuer fails to pay any Specified Taxes assessable or payable in respect of the issue or transfer and delivery of any Deliverable Shares (including the allotment, issue and delivery of Shares represented thereby) to the relevant Bondholder, the relevant Bondholder shall be entitled to tender and pay the same and the Issuer, as a separate and independent stipulation, covenants to reimburse and indemnify each Bondholder in respect of any payment thereof and any interest and penalties payable and documented costs incurred in respect thereof.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) If the exercise of a Share Settlement Option results in a transfer tax being assessed on any Bondholder, the Issuer shall reimburse each affected Bondholder by issuing or transferring and delivering Shares (or, if the Issuer is unable or otherwise not permitted for reason to deliver such Shares, in cash) no longer than the second Brussels business day after the relevant Interest Payment Date or Amortisation Payment Date (including, for the avoidance of doubt, an Advanced Amortisation

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Payment Date) at the same Relevant Share Settlement Price that applied in respect of such payment of interest amount or Amortised Payment Amount.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) A Bondholder must pay any capital, stamp, issue and registration and transfer taxes or duties arising on the issue or transfer and delivery of the relevant Deliverable Shares, excluding any Specified Taxes or other taxes specified in paragraph (iii) above (which shall be payable by the Issuer). Such Bondholder must pay, or procure payment of, all, if any, taxes arising by reference to any disposal or deemed disposal of a Bond or interest therein by it in connection with the exercise of such Share Settlement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) Deliverable Shares will be deemed to be issued and/or transferred and delivered as of the relevant SSO Registration Date and the Issuer shall procure that such SSO Registration Date in respect thereof shall occur no later than the Scheduled SSO Delivery Date in respect of such Deliverable Shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) Upon delivery by the Issuer of an Interest Share Settlement Option Notice or Principal Share Settlement Option Notice, each Bondholder shall be required to confirm whether it elects for the Deliverable Shares to be issued or transferred and delivered in relation to such Share Settlement to be either US Shares or Belgian Shares or a combination thereof (the "**Belgian/US Share Confirmation**" in respect of such Share Settlement and such Bondholder), *provided that* such Belgian/US Share Confirmation shall be so given:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(A) (where such Principal Share Settlement Option Notice or Interest Share Settlement Option Notice is given in relation to an Advanced Amortised Payment Amount or interest accrued and unpaid thereon, as the case may be) in the relevant Amortised Payment Advancement Notice; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(B) (in any other case) by giving notice in writing to the Issuer in accordance with Condition 16 (*Notices*) (which may be by email), with a copy to the Calculation Agent, no later than the Qualifying Business Day prior to the Interest Payment Date or Scheduled Amortisation Payment Date, as the case may be, in relation to which such Interest Share Settlement Option Notice or Principal Share Settlement Option Notice, as the case may be, was given (provided that if delivery of the Belgian/US Share Confirmation is made after 1:00 p.m. Brussels time or on a day which is not a Qualifying Business Day, such delivery shall be deemed for all purposes of these Conditions to have been made on the next following Qualifying Business Day), failing which proviso (B) to the definition of "Scheduled SSO Delivery Date" shall apply in respect of such Share Settlement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) Deliverable Shares to be issued or transferred and delivered in relation to a Share Settlement will be issued or transferred and delivered in uncertificated form through the dematerialised securities trading system operated by Euroclear Belgium (in the case of Belgian Shares) or DTC (in the case of US Shares).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(viii) Where Deliverable Shares are to be issued or transferred and delivered through the Euroclear Belgium or DTC, they will be delivered to the account specified by the relevant Bondholder in the Payment Details.

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**10.** **Events of Default**

If any of the following events (each an "**Event of Default**") occurs and is continuing, the holders of at least one-quarter in principal amount of the Bonds then outstanding may give notice in writing to the Issuer that the Bonds are, and upon such notice the Bonds shall accordingly immediately become, without further action or formality, due and repayable in cash at (but without prejudice to the rights of Bondholders to require the Issuer to issue or transfer and deliver Shares as provided below) the Early Redemption Amount:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) default in the payment when due of any interest or any other amounts (other than principal) with respect to the Bonds or, if such default is caused by a Disruption Event, on the second Brussels business day after the Disruption Event has been remedied;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) default in the payment when due of the principal of the Bonds (on an Amortisation Payment Date, at final maturity, upon redemption or otherwise) or, if such default is caused by a Disruption Event, on the second Brussels business day after the Disruption Event has been remedied;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) the Issuer fails to deliver Shares following any exercise of Conversion Rights or in respect of any Share Settlement Option on the date specified in these Conditions;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) the Issuer does not perform or comply with any of its respective obligations under Condition 2 (*Covenants*), Condition 11(c) (*Undertakings*) or Condition 11(k) (*Undertakings*);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) the Issuer does not perform or comply with any one or more of its other obligations in the Bonds or the Bond Documents or if any event occurs or any action is taken or failed to be taken which is (or but for the provisions of any applicable law would be) a breach of any such obligation, and which default or breach is incapable of remedy or is not remedied within five Brussels business days after the earlier of (i) the date the Issuer became aware of such default or breach or (ii) notice of such default or breach shall have been received by the Issuer from any Bondholder requiring the same to be remedied;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) any other present or future Financial Indebtedness of the Issuer or any of its Subsidiaries is not paid when due or (as the case may be) within any originally applicable grace period, or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) any such Financial Indebtedness becomes (or becomes capable of being declared) due and payable prior to its stated maturity or scheduled due date by reason of an event of default or prepayment event or put option event or the like (howsoever described), or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) the Issuer or any of its Subsidiaries fails to pay when due any amount payable by it under any present or future Financial Indebtedness Guarantee,

*provided that* the aggregate amount of the relevant Financial Indebtedness and/or Financial Indebtedness Guarantee in respect of which one or more of the events mentioned above in this Condition 10(f) (*Events of Default*) have occurred equals or exceeds €3,000,000 (or its equivalent in any other currency or currencies);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) one or more final, non-appealable judgments or orders or arbitration awards for the payment an amount in excess of €3,000,000 (or its equivalent in any other currency or

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currencies), whether individually or in aggregate, is rendered or granted against the Issuer or any of its Subsidiaries and continue(s) unsatisfied and unstayed for a period of 30 days after the date thereof or, if later, the date therein specified for payment;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) a distress, attachment, execution or other legal process is levied, enforced or sued out on or against the property, assets or revenues of the Issuer or any of its Subsidiaries with a value, individually or in the aggregate, in excess of €3,000,000 (or its equivalent in any other currency or currencies) and is not discharged within 30 days;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) any mortgage, charge, pledge, lien or other encumbrance, present or future, created or assumed by the Issuer or any of its Subsidiaries, over assets with a value, individually or in the aggregate, in excess of €3,000,000 (or its equivalent in any other currency or currencies), becomes enforceable and any step is taken to enforce it (including the taking of possession or the appointment of a receiver, administrative receiver, administrator, manager or other similar person) and is not discharged, stayed or stopped within 30 days;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(j) the Issuer or any of its Subsidiaries is (or is deemed by law or a court or its auditors to be) insolvent or bankrupt or no longer a going concern or unable to pay its debts as they fall due, or stops, suspends or announces its intention to stop or suspend payment of any of its debts or, by reason of actual or anticipated financial difficulties, the Issuer or any of its Subsidiaries commences negotiations with one or more of its creditors with a view to deferring, rescheduling or otherwise readjusting generally its Financial Indebtedness for or in respect of moneys borrowed or raised, or an insolvency administrator (including a *curateur* / *curator* and a *médiateur d'entreprise/ondernemingsbemiddelaar* under Book XX of the Belgian Code of Economic Law), or a liquidator of the Issuer or any of its Subsidiaries is appointed (or application for any such appointment is made) other than in the context of a solvent liquidation or a moratorium is agreed or declared or comes into effect in respect of or affecting any debt of the Issuer or any of its Subsidiaries; or any court

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(k) an administrator is appointed, an order is made or an effective resolution passed for the winding-up or dissolution or administration of the Issuer or any of its Subsidiaries (and such order is not discharged within 30 days), or the Issuer (itself, or taken together with its Subsidiaries) ceases or threatens to cease to carry on all or any substantial part of its business or operations (or disposes of any substantial part of its assets), except for the purpose of and followed by a reconstruction, amalgamation, reorganisation, merger or consolidation on terms approved by the Bondholders;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(l) any representation or statement made or deemed to be made by the Issuer in the Subscription Agreement (or other purchase or similar agreements entered into between the Issuer and any Bondholder in connection with the Bonds) is or proves to have been incorrect or misleading in any material respect when made or deemed to be made and is not remedied within five Brussels business days of the earlier of (i) the initial subscriber named therein giving notice to the Issuer, and (ii) the Issuer becoming aware of the event or circumstance giving rise to the representation or warranty being incorrect; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(m) any event occurs which under the laws of Belgium or other jurisdiction of incorporation of the Issuer or its Subsidiaries has an analogous effect to any of the events referred to in paragraphs (h) to (k) (inclusive).

Upon notice being given as provided in the first paragraph of this Condition 10 and the Bonds being due and repayable at the relevant Early Redemption Amount together with any accrued and unpaid interest to (but excluding) the date of such notice, each Bondholder may, in its sole discretion, upon giving notice to the Issuer no later than five London and Brussels business days after the giving of

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the notice described in the first paragraph of this Condition 10, require the Issuer to issue or transfer and deliver Shares in lieu of such amounts being paid in cash, *provided that* the Issuer shall not be required under any circumstance to issue or transfer and deliver any Shares under this paragraph to the extent that such issuance or transfer and delivery would cause or result in Shares being required to be issued or transferred and delivered in violation of the Issuer's Articles of Association or otherwise not permitted by applicable laws or regulations. Upon the exercise of such right by a Bondholder (and subject to the foregoing), the Issuer shall issue or transfer and deliver Shares in respect of such amounts due and on the basis that Condition 9.9 (*Share Settlement Option*) applied, *mutatis mutandis*, assuming for this purpose that the Share Settlement Reference Date is the relevant Put SSO Reference Date, the Amortised Payment Amount in respect of which the Share Settlement Option is exercised is such Early Redemption Amount, the interest amount (if any) in respect of which the Share Settlement Option is exercised is the accrued and unpaid interest (if any) up to (but excluding) the date of such notice, the Scheduled SSO Delivery Date is the first date on which the Early Redemption Amount is capable of being determined in accordance with these Conditions and that the occurrence of any Share Settlement Liquidity Event is ignored and deemed to not have occurred.

Following an Event of Default and the relevant Bondholders having given notice to the Issuer that the Bonds are due and payable, references in these Conditions and the Bond Instrument to the principal amount of the Bonds shall, unless the context otherwise requires, include the Early Redemption Amount.

An Event of Default shall be deemed to be continuing if it has not been remedied or waived.

**11.** **Undertakings**

Whilst any Conversion Right remains exercisable, the Issuer will, save with the approval of the holders of at least 90 per cent. in principal amount of the Bonds outstanding:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) not issue or pay up any Securities, in either case by way of capitalisation of profits or reserves or for no consideration, other than:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) by the issue of fully paid Shares or other Securities to Shareholders and other

holders of shares of the Issuer which by their terms entitle the holders thereof to receive shares or other Securities on a capitalisation of profits or reserves; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) by the issue of fully paid Shares, issued wholly, ignoring fractional entitlements, in lieu of the whole or part of a Dividend in cash; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) by the issue of fully paid Shares to the Issuer itself for no consideration, to be further conveyed as treasury shares against consideration; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) by the issue of Shares or any equity shares or other Securities to, or for the benefit of, employees or former employees, director or executive holding or formerly holding executive office (including directors holding or formerly holding executive office or non-executive office, consultants or former consultants or the personal service company of any such person) or their spouses or relatives, in each case of the Issuer or any of its Subsidiaries or any associated company or to a trustee or nominee to be held for the benefit of any such person, in any such case pursuant to an employee, contractor, director or executive share or option or incentive scheme whether for all employees, contractors, directors or executives or any one or more of them,

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((i) to (iv) above each being a "**Permitted Issue**"), unless, in any such case, the same constitutes a Dividend or otherwise falls to be taken into account for a determination as to whether an adjustment is to be made to the Conversion Price pursuant to Condition 6.2 (*Adjustment of Conversion Price*), regardless of whether in fact an adjustment falls to be made in respect of the relevant event (or would, but for the provisions of Condition 6.7 (*Rounding Down and Notice of Adjustment to the Conversion Price*) relating to roundings and minimum adjustments or the carry forward of adjustments, give rise to an adjustment to the Conversion Price);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) not modify the rights attaching to the Shares with respect to voting, dividends or liquidation nor issue any other class of equity shares carrying any rights which are more favourable than the rights attaching to the Shares but so that nothing in this Condition 11(b) shall prevent:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) any consolidation, reclassification, redesignation or subdivision of the Shares; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) any modification of such rights which is not, in the opinion of an Independent Adviser, materially prejudicial to the interests of the holders of the Bonds; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) any issue of equity shares where the issue of such equity shares results, or would, but for the provisions of Condition 6.7 (*Rounding Down and Notice of Adjustment to the Conversion Price*) relating to roundings and minimum adjustments or the carry forward of adjustments or Condition 6.2(l) (*Modifications*) or, where comprising Shares, the fact that the consideration per Share receivable therefor is at least 95 per cent. of the Current Market Price per Share at the relevant time for determination thereof pursuant to the relevant provisions of Condition 6.2 (*Adjustment of Conversion Price*), otherwise result, in an adjustment to the Conversion Price; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) without prejudice to any rule of law or legislation, the conversion of Shares into, or the issue of any Shares in, uncertificated form (or the conversion of Shares in uncertificated form to certificated form) or the amendment of the constitutional documents of the Issuer to enable title to securities (including Shares) to be evidenced and transferred without a written instrument or any other alteration to the constitutional documents of the Issuer made in connection with the matters described in this Condition 11(b) or which is supplemental or incidental to any of the foregoing (including any amendment made to enable or facilitate procedures relating to such matters and any amendment dealing with the rights and obligations of holders of Securities, including Shares, dealt with under such procedures); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) any issue of equity shares or modification of rights attaching to the Shares, where prior thereto the Issuer shall have instructed an Independent Adviser to determine what (if any) adjustments should be made to the Conversion Price as being fair and reasonable to take account thereof and such Independent Adviser shall have determined either that no adjustment is required or that an adjustment resulting in a decrease in the Conversion Price is required and, if so, the new Conversion Price as a result thereof and the basis upon which such adjustment is to be made and, in any such case, the date on which the adjustment shall take effect (and so that the adjustment shall be made and shall take effect accordingly); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) any alteration to the constitutional documents of the Issuer made in connection with the matters described in this Condition 11 or which is supplemental or incidental to any of the foregoing (including any amendment made to enable or

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facilitate procedures relating to such matters and any amendment dealing with the rights and obligations of holders of Securities, including Shares, dealt with under such procedures); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) any amendment of the constitutional documents of the Issuer following or in connection with a Change of Control to ensure that any Bondholder exercising Conversion Rights where the Conversion Date falls on or after the occurrence of a Change of Control will receive, in whatever manner, the same consideration for the Shares arising on such exercise as it would have received in respect of any Shares had such Shares been submitted into, and accepted pursuant to, the relevant offer or tender (a "**Change of Control Conversion Right Amendment** "); or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(viii) a Permitted Issue;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) not issue any other class of equity shares nor any rights or options in respect thereof, in each case without the prior consent of the Majority Bondholders;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) except as part of or in connection with or pursuant to any employee, contractor, director or executive share or option or incentive scheme (whether for all employees, contractors, directors or executives or any one or more of them), procure that no Securities which were originally issued (whether issued by the Issuer or any Subsidiary of the Issuer or procured by the Issuer or any Subsidiary of the Issuer to be issued or issued by any other person pursuant to any arrangement with the Issuer or any Subsidiary of the Issuer) without rights to convert into, or exchange or subscribe for, Shares shall subsequently be granted such rights exercisable at a consideration per Share which is less than 95 per cent. of the Current Market Price per Share at the relevant time for determination thereof pursuant to the relevant provisions of Condition 6.2 (*Adjustment of Conversion Price*) unless the same gives rise (or would, but for the provisions of Condition 6.7 (*Rounding Down and Notice of Adjustment to the Conversion Price*) relating to roundings and minimum adjustments or the carry forward of adjustments or Condition 6.2(l) (*Modifications*), give rise) to an adjustment to the Conversion Price and that at no time shall there be in issue Shares of differing nominal values, save where such Shares have the same economic rights;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) not make any issue, grant or distribution or take or omit to take any other action if the effect thereof would be that, on the exercise of Conversion Rights or any Share Settlement Option, Shares could not, under any applicable law then in effect, be legally issued as fully paid;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) not reduce its total issued shares, share capital, share premium account, or any uncalled liability in respect thereof, or any non-distributable reserves, except:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) pursuant to the terms of issue of the relevant shares; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) by means of a purchase or redemption of shares of the Issuer to the extent permitted by applicable law; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) where the reduction does not involve any distribution of assets to Shareholders; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) to create distributable or non-distributable reserves, or (as relevant) to create additional issue premiums;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(v) absorb accounting losses recognised by the Issuer to create a reserve to absorb foreseeable accounting losses or to create an unavailable reserve in accordance with the Belgian Companies and Associations Code; or

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vi) by way of transfer to reserves as permitted under applicable law; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(vii) where the reduction is permitted by applicable law and the Bondholders are advised by an Independent Adviser, acting as an expert, that in its opinion the interests of the Bondholders will not be materially prejudiced by such reduction; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(viii) where the reduction is permitted by applicable law and results (or, in the case of a reduction in connection with a Change of Control, will result) in (or would, but for the provisions of Condition 6.7 (*Rounding Down and Notice of Adjustment to the Conversion Price*) relating to roundings or the carry forward of adjustments, result in) an adjustment to the Conversion Price or is (or, in the case of a reduction in connection with a Change of Control, will be) otherwise taken into account for the purposes of determining whether such an adjustment should be made,

provided that, without prejudice to the other provisions of these Conditions, the Issuer may exercise such rights as it may from time to time be entitled pursuant to applicable law to purchase, redeem or buy back its Shares and any depositary or other receipts or certificates representing Shares without the consent of Bondholders;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) if any offer is made to all (or as nearly as may be practicable all) Shareholders (or all (or as nearly as may be practicable all)) Shareholders other than the offeror and/or any parties acting in concert with the offeror (as defined in Article 3, paragraph 1, 5° of the Belgian law of 1 April 2007 on public takeover bids or any modification or re-enactment thereof) to acquire the whole or any part of the issued Shares, or if any person proposes a scheme with regard to such acquisition, give notice of such offer or scheme to the Bondholders in accordance with Condition 16 (*Notices*) at the same time as any notice thereof is sent to the Shareholders (or as soon as practicable thereafter) that details concerning such offer or scheme may be obtained from the Issuer and, where such an offer or scheme has been recommended by the board of directors of the Issuer, or where such an offer has become or been declared unconditional in all respects or such scheme has become effective, use all reasonable endeavours to procure that a like offer or scheme is extended to Bondholders and to the holders of any Shares issued during the period of the offer or scheme arising out of the exercise of the Conversion Rights pursuant to these Conditions (which like offer or scheme to Bondholders shall entitle Bondholders to receive the same type and amount of consideration they would have received had they held the number of Shares to which such Bondholders would be entitled assuming Bondholders were to exercise their Conversion Rights in a Relevant Event Period), provided that, for the avoidance of doubt, this undertaking of the Issuer shall not restrict or prevent the Issuer or its board of directors from co-operating in relation to, or recommending to its shareholders the acceptance of, such a takeover bid in circumstances where (despite the Issuer using all reasonable endeavours as set out above) the bidder does not extend to the Bondholders (or any of them) an offer or proposal as set out above;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) use its best efforts to ensure that the Shares issued and/or transferred and delivered upon exercise of Conversion Rights (if any) will, as soon as is practicable, be listed and admitted to trading on the Relevant Stock Exchange and will be listed, quoted or dealt in, as soon as is reasonably practicable, on any other stock exchange or securities market on which the Shares may then be listed or quoted or dealt in (but so that this undertaking shall be considered as not being breached as a result of a Change of Control (whether or not recommended or approved by the board of directors of the Issuer) that causes or gives rise to, whether following the operation of any applicable compulsory acquisition provision or

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otherwise, (including at the request of the person or persons Controlling the Issuer as a result of the Change of Control) a de-listing of the Shares);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) use its best efforts to ensure, at its own cost, that its issued and outstanding Shares are admitted to listing on a regulated, regularly operating, recognised stock exchange, multilateral trading facility or securities market (but so that this undertaking shall be considered as not being breached as a result of a Change of Control (whether or not recommended or approved by the board of directors of the Issuer) that causes or gives rise to, whether following the operation of any applicable compulsory acquisition provision or otherwise, (including at the request of the person or persons Controlling the Issuer as a result of the Change of Control) a de-listing of the Shares);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(j) procure that it shall not become domiciled or resident in or subject generally to the taxing authority of any jurisdiction (other than Belgium or within Belgium) unless:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) it would not thereafter be required pursuant to then current laws and regulations to make any greater withholding or deduction for or on account of any taxes, duties, assessments or governmental charges of whatever nature imposed or levied by or on behalf of such jurisdiction or any applicable sub-division thereof or therein having power to tax; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) holders of the Bonds (whether upon transfer of Bonds or otherwise) would not thereafter be required to pay any additional stamp, issue, transfer, documentary or other similar taxes and duties,

in each case in respect of any payment on or in respect of the Bonds or the Bond Documents, or the transfer of any Bonds, (as applicable) than would be the case were the Issuer to remain domiciled and resident solely within Belgium;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(k) at all times:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) maintain and ensure sufficient approvals and authorisations to enable the issue of Shares as required pursuant to these Conditions (and ignoring, for the purposes of this Condition 11(k) (*Undertakings*), the provisions of Condition 12 (*Regulatory Share Cap*)) upon the exercise of Conversion Rights and any Share Settlement Option in respect of the Bonds (including Further Bonds) which, for the avoidance of doubt, shall include the satisfaction of any requirements on the Issuer to publish a prospectus or other offer document in accordance with Regulation (EU) 2017/1129 and/or the rules of any Relevant Stock Exchange; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) keep available for issue, free from pre-emptive or other preferential rights out of its authorised but unissued Shares to enable the issue of Shares as required pursuant to these Conditions (and ignoring, for the purposes of this Condition 11(k), the provisions of Condition 12 (*Regulatory Share Cap*)) upon the exercise of Conversion Rights and any Share Settlement Option in respect of all the Bonds (including any Further Bonds) then outstanding and all other rights of subscription and exchange for Shares, to be satisfied in full.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(l) with respect to any calculation, determination, verification or adjustment performed by the Calculation Agent or an Independent Adviser at the instruction of the Issuer, promptly notify or procure that the Issuer promptly notifies the Bondholders thereof including all relevant details of such calculation, determination or verification and, upon request from any Bondholder, confirm to the Bondholders (and with notice to the Calculation Agent)

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the Conversion Price then in effect and details of any relevant prior calculations, determinations, verifications or adjustments as such Bondholder may require;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(m) promptly upon:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) the Issuer becoming aware that a Free Float Event may have occurred (or would be likely to have occurred, if an Independent Adviser had been requested to make such determination), acting reasonably, based on publicly available information; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) a request being made by the Majority Bondholders (acting reasonably),

the Issuer shall instruct an Independent Adviser to make a determination as to the number of Shares comprising the Free Float;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(n) unless to do so shall be in breach of applicable law, promptly notify each Bondholder in accordance with Condition 16 (*Notices*) of the occurrence of any Share Settlement Liquidity Event, any Potential Event of Default or any Event of Default;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(o) so far as permitted by applicable law and any applicable contractual obligations of confidentiality, at any time upon request from holders of least one-tenth in principal amount of the Bonds then outstanding, as soon as practicable furnish to each Bondholder such information or materials as may be relevant to the operation of any of the provisions in the Bond Documents, including but not limited to any potential Relevant Event or Share Settlement Liquidity Event and the relevant supporting calculations, evidence of the Issuer's due and punctual performance of its obligations under the Bonds and the Bond Documents, provided that the Issuer shall not (without first entering into a separate confidentiality agreement with the relevant Bondholders) furnish any such information to the relevant Bondholders if it is reasonably expected to constitute Restricted Information; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(p) &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) use its best efforts to ensure that the Change of Control Resolutions are presented to the Shareholders of the Issuer in a general meeting of Shareholders before the Longstop Date; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) promptly after such approval by the general meeting of Shareholders and before the Longstop Date, file a copy of such Change of Control Resolutions with the clerk's office of the competent Enterprise Court in accordance with the provisions of the Belgian Companies and Associations Code.

**12.** **Regulatory Share Cap**

Notwithstanding anything herein to the contrary, the Issuer shall not be obligated to settle any obligation under these Conditions in Shares (including any Share Settlement of interest or principal including by way of the Issuer treating an issue of Shares as a conversion of the relevant amounts due under the Bonds into Shares) if and to the extent such settlement in Shares would cause the issue, conversion or delivery of more Shares than permitted by applicable Belgian law, in which case the Issuer shall instead settle such obligations in cash as if it had made a Cash Alternative Election (and such Shares which are not issued owing to the foregoing are deemed to be Cash Settled Shares, and the date by which such Shares would otherwise have been required to be delivered deemed to be the Conversion Date for the purpose of calculating the Cash Alternative Amount) pursuant to Condition 6.10 (*Cash Alternative Election*) in respect thereof.

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**13.** **Prescription**

Claims against the Issuer for payment in respect of the Bonds shall be prescribed and become void unless made within 10 years (in the case of principal or any other amount (other than interest)) or five years (in the case of interest) from the appropriate Relevant Date in respect of such payment.

Claims in respect of any other obligation in respect of the Bonds, including delivery of Shares, shall be prescribed and become void unless made within three years following the due date for performance of the relevant obligations.

**14.** **Replacement of Bond Certificates**

If any Bond Certificate is lost, stolen, mutilated, defaced or destroyed, it may be replaced by the Issuer subject to and in accordance with Clause 4.6 (*Replacement of Bond Certificates*) of the Bond Instrument.

**15.** **Amendment and Waiver**

**15.1** **Amendment**

Subject to Condition 15.2 (*Reserved Matters*), the Bonds and the Bond Documents may be amended, or waivers or consents given in respect thereof, with the agreement of the Issuer and the Majority Bondholders and (without prejudice to the terms of the Calculation Agency Agreement) any such amendment, waiver or consent will be binding on all Bondholders and shall be notified by the Issuer to Bondholders as soon as practicable.

**15.2** **Reserved Matters**

The Issuer shall not agree to make any amendment, and no waiver or consent shall be effective, in respect of any Bondholder Reserved Matter, without the consent of the holders of at least 75 per cent. in principal amount of the Bonds outstanding.

**15.3** **Voting Evidence**

In relation to any consent to be provided by Bondholders in accordance with the Bonds or the relevant Bond Documents, the Issuer shall provide or procure the provision of evidence satisfactory to each Bondholder (in each case acting reasonably) that specifies:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the principal amount outstanding held by each Bondholder that delivered an instruction to consent, abstain or dissent to any proposal; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the principal amount outstanding of Bonds held by or on behalf of the Issuer or any of its Subsidiaries or any of their respective affiliates (as referred to in the definition of "outstanding" in Condition 3 (*Definitions*)).

**16.** **Notices**

All notices required to be given to the Issuer or any Bondholder pursuant to these Conditions will (unless otherwise provided in these Conditions) be given:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) in the case of the initial Bondholder, in accordance with the terms of the Subscription Agreement; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) in the case of any New Holder (as defined in the Bond Instrument), in writing by letter or email to the address specified in each duly executed and completed form of transfer,

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

or, in each case, to such other contact details as any Bondholder may subsequently provide in writing to the Issuer from time to time in accordance with the Bond Instrument.

Any notice given under these Conditions shall take effect, in the case of a letter, at the time of delivery, or in the case of email transmission, at the time of despatch (unless a delivery failure notification is received by the sender within 12 hours of sending such communication, in which case such notice shall be deemed not to have taken effect). If, only in respect of matters where Brussels business days are specified, such delivery or despatch is made after 5:00 p.m. (Brussels time) or on a day which is not a Brussels business day, such delivery shall be deemed to have been made on the next following Brussels business day, as applicable.

If any notice required to be given pursuant to these Conditions would otherwise contain any Restricted Information then the Issuer shall simultaneously with such notice make a public announcement containing all such Restricted Information such that the notice to the Bondholders shall not contain any Restricted Information, unless otherwise approved in writing by the Majority Bondholders, or the Issuer has delayed the disclosure of Restricted Information pursuant to Regulation 596/2014/EU, in which case the Issuer shall inform the Bondholders of the nature of such Restricted Information prior to providing the relevant notice and confirm in writing whether each Bondholder is willing to receive such Restricted Information and comply with applicable laws and regulations stipulating the receipt and restrictions related thereto.

The Issuer shall send a copy of all notices given by it to Bondholders (or a Bondholder) pursuant to these Conditions promptly to the Calculation Agent.

**17.** **Beneficial Ownership of Shares**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) If, at any time, the Issuer shall become a Reporting Company in the United States then, notwithstanding any other provision of these Conditions or the Bond Documents, each Bondholder, together with its other Attribution Parties, shall not at any time own or acquire the beneficial ownership of more than 9.99 per cent. of the issued and outstanding Shares in the Issuer (the "**Maximum Percentage** ").

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) For the purposes of paragraph (a) above, the aggregate number of Shares beneficially owned by a Bondholder and its other Attribution Parties shall include the number of Shares held by such Bondholder and all other Attribution Parties, plus the number of Shares issuable upon the exercise of Conversion Rights or Share Settlement Option in respect of any Bond, in each case with respect to which the determination of such provision is being made, but shall exclude Shares which would be issuable upon:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) conversion of the remaining, non-converted portion of any Bond beneficially owned by the initial Bondholder or any of the other Attribution Parties, as the case may be, including any Share Settlement Option under the Bonds; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) the exercise or conversion of the unexercised or non-converted portion of any other Securities (as defined in the Conditions) of the Issuer that are beneficially owned by a Bondholder or any other Attribution Party, subject to a limitation on conversion or exercise analogous to the limitation contained in paragraph (a) above.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) For the purposes of paragraph (a) above, beneficial ownership shall be calculated in accordance with Section 13(d) of the Exchange Act. For the purposes of determining the number of outstanding Shares a Bondholder may acquire upon the conversion of any Bond or following any exercise of any Share Settlement Option under the Bonds without

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

exceeding the Maximum Percentage, such Bondholder may rely on the number of outstanding Shares as reflected in (i) the Issuer's most recent Annual Report on Form 20-F, Report on Form 6-K or other public filing with the SEC, as the case may be, (ii) a more recent public announcement by the Issuer or (iii) any other written notice by the Issuer setting forth the number of Shares outstanding (in either case, the "**Reported Outstanding Share Number**").

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) If the Issuer receives a Conversion Notice from a Bondholder at a time when the actual number of outstanding Shares is less than the Reported Outstanding Share Number, the Issuer shall notify such Bondholder in writing of the number of Shares then outstanding and, to the extent that such exercise of Conversion Rights would otherwise cause that Bondholder's beneficial ownership, as determined pursuant to this Condition, to exceed the Maximum Percentage, the relevant Bondholder must notify the Issuer of a reduced number of Shares to be purchased pursuant to such exercise of Conversion Rights.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) The Issuer shall promptly on demand by any Bondholder (and in any event by no later than one Brussels business day after demand) confirm in writing to such Bondholder the relevant number of Shares outstanding at such date. The number of outstanding Shares shall be determined after giving effect to the conversion or exercise of Securities of the Issuer, including any Bond and any Share Settlement Option, by the relevant Bondholder and any other Attribution Party since the date as of which the Reported Outstanding Share Number was reported. In the event that the issuance or transfer and delivery of Shares to a Bondholder upon conversion of any Bond or exercise of any Share Settlement Option results in that Bondholder and the other Attribution Parties being deemed to beneficially own, in the aggregate, more than the Maximum Percentage of the number of outstanding Shares (as determined under Section 13(d) of the Exchange Act), the number of Shares so issued or delivered by which that Bondholder's and the other Attribution Parties' aggregate beneficial ownership exceeds the Maximum Percentage (the "**Excess Shares**") shall be deemed null and void and shall be cancelled ab initio, and such Bondholder shall not have the power to vote or to transfer the Excess Shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) The Shares issuable pursuant to the terms of any Bond in excess of the Maximum Percentage shall not be deemed to be beneficially owned by a Bondholder for any purpose including for purposes of Section 13(d) or Rule 16a-1(a)(1) of the Exchange Act. No prior inability to convert any Bond shall have any effect on the applicability of the provisions of this Condition 17 with respect to any subsequent determination of convertibility. The provisions of this Condition shall be construed and implemented in a manner otherwise than in strict conformity with the terms of this Condition 17 to the extent necessary to correct this Condition 17 (or any portion of this Condition 17) which may be defective or inconsistent with the intended beneficial ownership limitation contained in this Condition 17 or to make changes or supplements necessary or desirable to properly give effect to such limitation.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) The limitation contained in this Condition 17 may not be waived.

**18.** **Further Issues**

The Issuer may not create and issue Further Bonds except with the prior written approval of the Majority Bondholders. Any Further Bonds shall be constituted by a deed supplemental to the Bond Instrument.

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**19.** **Contracts (Rights of Third Parties) Act 1999**

Other than the Bondholders, no person shall have any right to enforce any term or condition of the Bonds under the Contracts (Rights of Third Parties) Act 1999, or, with respect to provisions governed by Belgian law under Condition 20 (*Governing Law*), under any similar applicable

Belgian law (including, without limitation, under Article 5.107 of the Belgian Civil Code) and no such right shall be inferred or implied from the Conditions either.

**20.** **Governing Law**

These Conditions, the Bond Instrument and the Bonds and any non-contractual obligations arising out of or in connection with them are governed by, and shall be construed in accordance with, English law, except that the provisions relating to ranking, status and subordination in Condition 1.3 (*Status*) and Condition 1.4 (*Subordination*) and the rights and obligations of the Issuer and the Bondholders in respect thereof, and any non-contractual obligations arising out of or in connection with them, shall be governed by and construed in accordance with the laws of Belgium.

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**In Witness Whereof** this Deed has been executed and delivered as a deed on the date stated at the beginning.

---

| | | | |
|:---|:---|:---|:---|
| **NYXOAH SA** |  |  |  |
| &nbsp;&nbsp;as ***Issuer*** | ![Graphic](nyxh-20251231xex4d23003.jpg) | By: | /s/ Olivier Taelman |
|  | ![Graphic](nyxh-20251231xex4d23003.jpg) | Name: | Olivier Taelman |
|  | ![Graphic](nyxh-20251231xex4d23003.jpg) | Title: | Director and CEO |

---

***[Signature page to the Bond Instrument]***

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***Certain identified information has been omitted from this exhibit because it is not material and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*] indicates that information has been omitted.***

**In Witness Whereof** this Deed has been executed and delivered as a deed on the date stated at the beginning.

---

| | | | |
|:---|:---|:---|:---|
| **NYXOAH SA** |  |  |  |
| &nbsp;&nbsp;as ***Issuer*** | ![Graphic](nyxh-20251231xex4d23003.jpg) | By: | /s/ John Landry |
|  | ![Graphic](nyxh-20251231xex4d23003.jpg) | Name: | John Landry |
|  | ![Graphic](nyxh-20251231xex4d23003.jpg) | Title: | CFO |

---

***[Signature page to the Bond Instrument]***

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## Exhibit 4.24

**Exhibit 4.24**

***Certain identified information has been omitted from this exhibit because it is not material***

***and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*]***

***indicates that information has been omitted.***

**EXCHANGE with Docusign**

**Nyxoah SA** (the "**Borrower**")

Rue Edouard Belin 12

1435 Mont-Saint-Guibert

Belgium

E-mail: [\*\*\*]

*For the attention of: Mr. Olivier Taelman, Chief Executive Officer*

Luxembourg, 16 December 2025 JU/OPS-POL/RFV/FA/PLU-AL/cc-N°2025-15637

---

| | |
|:---|:---|
| **Subject:** | **OSA RDI (IEU LS) (Serapis N°): 2023-0243; (FI N°): 96590** |

---

Finance contract between the European Investment Bank (the "**Bank**") and the Borrower dated 3 July 2024 (the "**Finance Contract**")

------

***Consent and Amendment* Letter**

We refer to the Finance Contract.

**1.** **DEFINITIONS AND INTERPRETATION**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.1. In this consent and amendment letter (the "**Letter** "):

"**Effective Date**" means the date on which the Bank confirms (including by electronic mail or other electronic means) to the Borrower that the Bank has received in form and substance satisfactory to it:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) this Letter in electronic form duly signed by all Parties with QES;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) evidence that the execution of this Letter by the Borrower has been duly authorised and that the person or persons signing this Letter on behalf of the Borrower is/are duly authorised to do so. Such evidence must be provided by the Borrower together with this duly signed Letter, unless it has been previously delivered to the Bank, or the Borrower confirms in writing that no change has occurred in relation to the authority of the person or persons authorised to sign this Letter on behalf of the Borrower; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) a PDF copy of the duly executed Bond Subscription Agreement.

"**Parties**" means the parties to this Letter.

"**QES**" means qualified electronic signatures in the meaning of Regulation (EU) No 910/2014 of the European Parliament and of the Council of 23 July 2014 on electronic identification and trust services for electronic transactions in the internal market and repealing Directive 1999/93/EC.

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***Certain identified information has been omitted from this exhibit because it is not material***

***and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*]***

***indicates that information has been omitted.***

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.2. Unless the context otherwise requires or unless otherwise defined, terms defined in the Finance Contract and expressions used in the Finance Contract have the same meaning when used in this Letter.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.3. The principles of construction set out in the Finance Contract shall have effect as if set out in this Letter.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.4. Any reference to an "Article" or a "Schedule" is, unless the context otherwise requires or it is indicated otherwise, a reference to an Article or a Schedule of this Letter.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.5. Article headings are for ease of reference only.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.6. With effect from the Effective Date, any reference in the Finance Contract to "this Contract" (or other similar references) shall be read and construed as a reference to the Finance Contract, as amended by this Letter.

**2.** **BACKGROUND**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.1. We refer to the exchanges between the Bank and the Borrower in connection with the request of consent to the subscription, by a new investor, of convertible bonds issued by the Borrower, in a maximum aggregate amount of EUR 45,000,000 (forty five million euro), due in December 2028, pursuant to a bond subscription agreement entered into between the Borrower and the new investor on 13 November 2025 and, whose effectiveness (i.e. issuance of the first tranche of bonds) is expected on or around 18 December 2025, as amended from time to time (the "**Bond Subscription Agreement**") (such subscription being the "**Notified Event** "), which includes, *inter alia*, the following provisions:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the payment obligations arising for the Borrower in connection with the convertible bonds rank subordinate to the Loan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.2. the convertible bond is converted into shares on quarterly basis until the maturity set in 3 (three) years;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) in case trading volumes of the Borrower shares fall below a given threshold, the repayment of the quarterly instalments of the bonds shall be made in cash.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.3. As a result of the Notified Event described in the first paragraph of Article 2 (*Background*) being completed the Bank would, under the Finance Documents, be entitled to, *inter alia*, demand immediate repayment by the Borrower of all or part of the Loan Outstanding, together with accrued interest, any Prepayment Fee and all other accrued or outstanding amounts under the Finance Contract in accordance with Paragraph (l) of Article 8.1 (*Right to demand repayment*) of the Finance Contract.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.4. In light of the above, the Borrower has requested the Bank to consent to the Notified Event and amend certain provisions of the Finance Documents, as further described below.

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***Certain identified information has been omitted from this exhibit because it is not material***

***and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*]***

***indicates that information has been omitted.***

**3.** **CONSENT**

With effect from the Effective Date, the Bank consents the Borrower to incur Indebtedness arising out of the Notified Event as described in the first paragraph of Article 2 (*Background*), in this Letter.

**4.** **AMENDMENTS TO THE FINANCE CONTRACT**

With effect from the Effective Date, the Finance Contract shall be amended as follows:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) A new definition of "*Bond Subscription Agreement*" shall be included in the "*Definitions*" section of the Finance Contract in alphabetical order and shall read as follows:

<<"***Bond Subscription Agreement****" means the subscription agreement entered into between the Borrower and CVI Investments, Inc. dated 13 November 2025 for a maximal aggregate amount of EUR 45,000,000 (forty-five million euro), as amended from time to time*;>>

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) A new Article 4.7.6 (*Convertible bonds*) of the Finance Contract shall be introduced stating the following:

***<<4.7.6 Convertible bonds***

*In case any amount under the Bond Subscription Agreement is likely to be paid by the Borrower, the Borrower shall promptly prepay the Loan Outstanding for the same amount, before any payment is made under the Bond Subscription Agreement. Any prepaid amount will be allocated only to repay principal. Accrued Fixed Rate interest until the Prepayment Date shall be payable on the next Payment Date and PIK Interest accrued until the Prepayment Date shall be payable at Maturity Date.>>*

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Article 4.7.6 (*Prepayment Fee*) of the Finance Contract shall be deleted in its entirety and replaced with the following:

***"4.7.7 Prepayment Fee***

*In the case of a Prepayment Event (other than pursuant to Article 4.7.3 (Illegality Event) and Article 4.7.6 (Convertible bonds)), in relation to a Tranche, the Borrower shall pay the relevant Prepayment Fee."*

**5.** **REPRESENTATIONS AND WARRANTIES**

With reference to the facts and circumstances then existing on:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) the date of the Borrower countersigns this Letter, and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) the Effective Date,

the Borrower represents and warrants to the Bank that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) all information provided to the Bank in connection with this Letter, in particular (without limitation) in respect of the Notified Event, is true and accurate in all respects as of (i) the date on which the Borrower sign this Letter and (ii) the Effective Date;

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***Certain identified information has been omitted from this exhibit because it is not material***

***and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*]***

***indicates that information has been omitted.***

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) no event or circumstance has occurred or arisen, no information has been omitted and no information has been given or withheld that results in the information provided by the Borrower to the Bank in connection with the Notified Event being untrue or misleading;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) the Notified Event have not resulted in a Material Adverse Change;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) the Notified Event did not, and does not, constitute any default (however described) or prepayment event under any financial obligations of the Borrower, except in relation to the Finance Documents as expressly set out in this Letter;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) the Borrower received all consents, waivers or authorisations (other than from the Bank pursuant to the Finance Documents) required to proceed with the Notified Event; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) all representations and warranties that are deemed repeated under and pursuant to Article 6 (*Borrower undertakings and representations*) of the Finance Contract as if each reference in those representations and warranties to "this Contract" included a reference to (i) the Finance Contract, as amended by this Letter; and (ii) this Letter.

**6.** **MISCELLANEOUS**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.1. Other than in accordance with the provisions of Article 3 (*Consent*) and Article 4 (*Amendment to the Finance Contract*) of this Letter, nothing in this Letter shall affect the rights of the Bank in respect of the occurrence of any Event of Default or breach (however described) or non-compliance in connection with the Finance Contract, including without limitation any Event of Default or breach (however described) or non-compliance in connection with the Finance Contract which has not been disclosed by the Borrower in writing prior to the date of this Letter or which arises on or after the date of this Letter.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.2. The provisions of the Finance Contract shall, save as amended by this Letter, continue in full force and effect. This Letter is not (and shall not be deemed to be) a consent, agreement, amendment or waiver in respect of any terms, provisions or conditions of the Finance Contract or the Guarantee Agreement, except as expressly agreed herein. The Bank reserves any other right or remedy it may have now or subsequently.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.3. This Letter does not entail a novation of, or have a novative effect on, the Finance Contract.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.4. The Bank issues this Letter acting in reliance upon the information supplied to the Bank by the Borrower until the date hereof in relation to such matters being true, complete and accurate. It shall be without prejudice to any rights which the Bank may have at any time in relation to any other circumstance or matter other than as specifically referred to in this Letter or in relation to any such information not being true, complete and accurate, which rights shall remain in full force and effect.

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***Certain identified information has been omitted from this exhibit because it is not material***

***and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*]***

***indicates that information has been omitted.***

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.5. The Borrower shall, at the request of the Bank and at its own expense, do all such acts and things necessary or desirable to give effect to the amendments effected or to be effected pursuant to this Letter.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.6. The Parties acknowledge and agree that any breach of this Letter, including (without limitation) any breach of an undertaking contained in this Letter or any representation in this Letter being or becoming incorrect, incomplete or misleading in any material respect, shall constitute an "Event of Default" under the Finance Contract.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.7. The Bank and the Borrower designate this Letter as a "Finance Document".

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6.8. The provisions of Articles 8.4 (*Non-Waiver*), 9.2 (*Jurisdiction*), 9.3 (*Place of performance*), 9.6 (*Invalidity*), 9.7 (*Amendments*), 9.8 (*Counterparts*), and 10. (*Notices*) of the Finance Contract shall be incorporated into this Letter as if set out in full in this Letter and as if references in those clauses to "this Contract" are references to this Letter.

**7.** **GOVERNING LAW AND JURISDICTION**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.1. This Letter and any non-contractual obligations arising out of or in connection with it shall be governed by Belgian law.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.2. The Courts of Brussels have exclusive jurisdiction to settle any dispute (a "**Dispute**") arising out of or in connection with this Letter (including a dispute regarding the existence, validity or termination of this Letter or the consequences of its nullity) or any non-contractual obligation arising out of or in connection with this Letter.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7.3. The Parties agree that the Courts of Brussels are the most appropriate and convenient courts to settle Disputes between them and, accordingly, that they will not argue to the contrary.

**8.** **EXCHANGE OF DOCUMENTS SIGNED WITH QES**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.1. Each Party confirms that it is its intention for this Letter to be executed upon signing by each Party of this Letter in the format of non-editable PDF and signed by each Party's authorised signatories with QES.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8.2. This Letter shall be deemed received by the other Party when it is actually received in readable form by the intended recipient at the following email addresses:

for the Bank: e-mail addresses: [\*\*\*]

and [\*\*\*]

for the Borrower:e-mail address: [\*\*\*]

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***Certain identified information has been omitted from this exhibit because it is not material***

***and would likely cause competitive harm to the registrant if publicly disclosed. [\*\*\*]***

***indicates that information has been omitted.***

EUROPEAN INVESTMENT BANK

<u>[\*\*\*]</u> &nbsp;&nbsp;&nbsp;&nbsp; <u>[\*\*\*]</u> <br> [\*\*\*] [\*\*\*] <br> Head of Division Legal Assistant

Agreed and accepted for and on behalf of

**Nyxoah SA**

as the Borrower

---

| |
|:---|
| /s/ Oliver Taelman |
| Name: Oliver Taelman |
| Title: Chief Executive Officer |
| Date: |

---

------

## Exhibit 12.1

**Exhibit 12.1**

**CERTIFICATIONS UNDER SECTION 302**

I, Olivier Taelman, certify that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. I have reviewed this annual report on Form 20-F of Nyxoah SA;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4. The registrant's other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a) designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b) designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;c) evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;d) disclosed in this report any change in the registrant's internal control over financial reporting that occurred during the registrant's most recent fiscal quarter (the registrant's fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5. The registrant's other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a) all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b) any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.

Date: March 26, 2026

---

| | |
|:---|:---|
| /s/ Olivier Taelman | /s/ Olivier Taelman |
| Name:  | Olivier Taelman |
| Title:  | Chief Executive Officer (Principal Executive Officer) |

---

------

## Exhibit 12.2

**Exhibit 12.2**

**CERTIFICATIONS UNDER SECTION 302**

I, John Landry, certify that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. I have reviewed this annual report on Form 20-F of Nyxoah SA;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4. The registrant's other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a) designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b) designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;c) evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;d) disclosed in this report any change in the registrant's internal control over financial reporting that occurred during the registrant's most recent fiscal quarter (the registrant's fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5. The registrant's other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a) all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b) any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.

Date: March 26, 2026

---

| | |
|:---|:---|
| /s/ John Landry | /s/ John Landry |
| Name:  | John Landry |
| Title:  | Chief Financial Officer (Principal Financial Officer) |

---

------

## Exhibit 13.1

**Exhibit 13.1**

**CERTIFICATIONS UNDER SECTION 906**

Pursuant to section 906 of the Sarbanes-Oxley Act of 2002 (subsections (a) and (b) of section 1350, chapter 63 of title 18, United States Code), each of the undersigned officers of Nyxoah SA, a Belgian public limited liability company (the "Company"), does hereby certify, to such officer's knowledge, that:

The Annual Report for the year ended December 31, 2025 (the "Form 20-F") of the Company fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, and the information contained in the Form 20-F fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date: March 26, 2026

---

| | |
|:---|:---|
| /s/ Olivier Taelman | /s/ Olivier Taelman |
| Name:  | Olivier Taelman |
| Title:  | Chief Executive Officer (Principal Executive Officer) |

---

------

## Exhibit 13.2

**Exhibit 13.2**

**CERTIFICATIONS UNDER SECTION 906**

Pursuant to section 906 of the Sarbanes-Oxley Act of 2002 (subsections (a) and (b) of section 1350, chapter 63 of title 18, United States Code), each of the undersigned officers of Nyxoah SA, a Belgian public limited liability company (the "Company"), does hereby certify, to such officer's knowledge, that:

The Annual Report for the year ended December 31, 2025 (the "Form 20-F") of the Company fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, and the information contained in the Form 20-F fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date: March 26, 2026

---

| | |
|:---|:---|
| /s/ John Landry  | /s/ John Landry  |
| Name:  | John Landry |
| Title:  | Chief Financial Officer (Principal Financial Officer) |

---

------

## Exhibit 15.1

**Exhibit 15.1**

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the following Registration Statements:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) Registration Statement (Form F-3 No 333-268955) of Nyxoah SA,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) Registration Statement (Form F-3 No. 333-285982) of Nyxoah SA,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3) Registration Statement (Form S-8 No. 333-285960) pertaining to the 2025 Warrants Plan of Nyxoah SA,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(4) Registration Statement (Form S-8 No. 333-283103) pertaining to the 2024 Warrants Plan of Nyxoah SA,

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(5) Registration Statement (Form S-8 No. 333-269410) pertaining to the 2022 Warrants Plan of Nyxoah SA, and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(6) Registration Statement (Form S-8 No 333-261233) pertaining to the 2013 Share Incentive Plan, 2016 Warrants Plan, 2018 Warrants Plan, 2020 Warrants Plan, and 2021 Warrants Plan of Nyxoah SA;

of our report dated March 26, 2026, with respect to the consolidated financial statements of Nyxoah SA included in this Annual Report (Form 20-F) of Nyxoah SA for the year ended December 31, 2025.

/s/ EY Réviseurs d'Entreprises / EY Berijfsrevisoren SRL/BV

Diegem, Belgium

March 26, 2026

------