# EDGAR Filing Document

**Accession Number:** 0001552740
**File Stem:** 0000940400-25-010085
**Filing Date:** 2025-11
**Character Count:** 20024
**Document Hash:** 3cdcc779c62b991e2de270da78c4afe6
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000940400-25-010085.hdr.sgml**: 20251125

**ACCESSION NUMBER**: 0000940400-25-010085

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20250930

**FILED AS OF DATE**: 20251125

**DATE AS OF CHANGE**: 20251125

**PERIOD START**: 20260331

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** FIRST TRUST EXCHANGE-TRADED FUND VI
- **CENTRAL INDEX KEY:** 0001552740

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** MA

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-22717
- **FILM NUMBER:** 251515752

**BUSINESS ADDRESS:**
- **STREET 1:** 120 EAST LIBERTY DRIVE, SUITE 400
- **CITY:** WHEATON
- **STATE:** IL
- **ZIP:** 60187
- **BUSINESS PHONE:** 630-765-8000

**MAIL ADDRESS:**
- **STREET 1:** 120 EAST LIBERTY DRIVE, SUITE 400
- **CITY:** WHEATON
- **STATE:** IL
- **ZIP:** 60187

## Series and Classes Contracts Data

### First Trust Indxx Medical Devices ETF (Series ID: S000071976)

| Class ID   | Class Name                            | Ticker Symbol   |
|:---|:---|:---|
| C000227613 | First Trust Indxx Medical Devices ETF | MDEV            |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** First Trust Exchange-Traded Fund VI

- **b. Investment Company Act file number:** 811-22717

- **c. CIK number of Registrant:** 0001552740

- **d. LEI of Registrant:** 549300ZLB3EUU3H8NE60

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 120 East Liberty Drive

  - **City:** Wheaton

  - **State:** IL

  - **Foreign country:** US

  - **Zip / Postal Code:** 60187

  - **Telephone number:** 630-765-8000

**Item A.2. Information about the Series.**

- **a. Name of Series:** First Trust Indxx Medical Devices ETF

- **b. EDGAR series identifier (if any):** S000071976

- **c. LEI of Series:** 549300I7ZP4IRE34QB73

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2026-03-31

- **b. Date as of which information is reported:** 2025-09-30

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $2001900.10

**Total Liabilities:** $1168.92

**Net Assets:** $2000731.18

**Cash Not Reported:** $0.21

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000227613 | -3.65%               | 3.43%                | -2.39%               |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $0.00                    | $-74474.21                                 |
| Month 2  | $0.00                    | $69136.52                                  |
| Month 3  | $0.00                    | $-50708.47                                 |

### Schedule of Portfolio Investments

| Name                               | Title                               | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Agilent Technologies Inc           | Agilent Technologies Inc            | CUSIP: 00846U101<br>LEI: QUIX8Y7A2WP0XRMW7G29 | Long             | EC               | CORP              | US        |       372 | NS      | $47746.20     | 2.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Siemens Healthineers AG            | Siemens Healthineers AG             | CUSIP: 000000000<br>LEI: 529900QBVWXMWANH7H45 | Long             | EC               | CORP              | DE        |       766 | NS      | $41386.93     | 2.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Teleflex Inc                       | Teleflex Inc                        | CUSIP: 879369106<br>LEI: UUL85LWXB4NGSWWXIQ25 | Long             | EC               | CORP              | US        |       288 | NS      | $35239.68     | 1.76%             |  |  |  | No            |                  1 | On Loan: No      |
| Bio-Rad Laboratories Inc           | Bio-Rad Laboratories Inc            | CUSIP: 090572207<br>LEI: 549300ZC1GPV35XYDK53 | Long             | EC               | CORP              | US        |       160 | NS      | $44862.40     | 2.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Boston Scientific Corp             | Boston Scientific Corp              | CUSIP: 101137107<br>LEI: Y6ZDD9FP4P8JSSJMW954 | Long             | EC               | CORP              | US        |       401 | NS      | $39149.63     | 1.96%             |  |  |  | No            |                  1 | On Loan: No      |
| Demant A/S                         | Demant A/S                          | CUSIP: 000000000<br>LEI: 213800RM6L9LN78BVA56 | Long             | EC               | CORP              | DK        |      1122 | NS      | $38858.52     | 1.94%             |  |  |  | No            |                  1 | On Loan: No      |
| Cooper Cos Inc/The                 | Cooper Cos Inc/The                  | CUSIP: 216648501<br>LEI: QJKMVPIGLH7530PCUE20 | Long             | EC               | CORP              | US        |       493 | NS      | $33800.08     | 1.69%             |  |  |  | No            |                  1 | On Loan: No      |
| Thermo Fisher Scientific Inc       | Thermo Fisher Scientific Inc        | CUSIP: 883556102<br>LEI: HCHV7422L5HDJZCRFL38 | Long             | EC               | CORP              | US        |        87 | NS      | $42196.74     | 2.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Hoya Corp                          | Hoya Corp                           | CUSIP: 000000000<br>LEI: 353800X4VR3BHEUCJB42 | Long             | EC               | CORP              | JP        |       394 | NS      | $54550.16     | 2.73%             |  |  |  | No            |                  1 | On Loan: No      |
| Stryker Corp                       | Stryker Corp                        | CUSIP: 863667101<br>LEI: 5493002F0SC4JTBU5137 | Long             | EC               | CORP              | US        |       107 | NS      | $39554.69     | 1.98%             |  |  |  | No            |                  1 | On Loan: No      |
| Baxter International Inc           | Baxter International Inc            | CUSIP: 071813109<br>LEI: J5OIVXX3P24RJRW5CK77 | Long             | EC               | CORP              | US        |      1322 | NS      | $30101.94     | 1.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Dexcom Inc                         | Dexcom Inc                          | CUSIP: 252131107<br>LEI: 549300YSK3QDSFR5EU59 | Long             | EC               | CORP              | US        |       553 | NS      | $37211.37     | 1.86%             |  |  |  | No            |                  1 | On Loan: No      |
| Intuitive Surgical Inc             | Intuitive Surgical Inc              | CUSIP: 46120E602<br>LEI: 54930052SRG011710797 | Long             | EC               | CORP              | US        |        76 | NS      | $33989.48     | 1.70%             |  |  |  | No            |                  1 | On Loan: No      |
| WuXi AppTec Co Ltd                 | WuXi AppTec Co Ltd                  | CUSIP: 000000000<br>LEI: 254900OEPQLZSPLN9175 | Long             | EC               | CORP              | CN        |      5685 | NS      | $86714.71     | 4.33%             |  |  |  | No            |                  1 | On Loan: No      |
| STERIS PLC                         | STERIS PLC                          | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       171 | NS      | $42312.24     | 2.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Alcon AG                           | Alcon AG                            | CUSIP: 000000000<br>LEI: 549300LDT5AP8S0NBM78 | Long             | EC               | CORP              | CH        |       428 | NS      | $31861.42     | 1.59%             |  |  |  | No            |                  1 | On Loan: No      |
| Dreyfus Government Cash Management | Dreyfus Government Cash Management  | CUSIP: 262006208<br>LEI: 5493000Q69I5Q3QZIA91 | Long             | STIV             | RF                | US        |      6432 | NS      | $6431.65      | 0.32%             |  |  |  | No            |                  1 | On Loan: No      |
| Abbott Laboratories                | Abbott Laboratories                 | CUSIP: 002824100<br>LEI: HQD377W2YR662HK5JX27 | Long             | EC               | CORP              | US        |       299 | NS      | $40048.06     | 2.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Olympus Corp                       | Olympus Corp                        | CUSIP: 000000000<br>LEI: 5299000Y52IFDI1I2A21 | Long             | EC               | CORP              | JP        |      2940 | NS      | $37196.06     | 1.86%             |  |  |  | No            |                  1 | On Loan: No      |
| Hologic Inc                        | Hologic Inc                         | CUSIP: 436440101<br>LEI: 549300DYP6F5ZJL0LB74 | Long             | EC               | CORP              | US        |       651 | NS      | $43935.99     | 2.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Becton Dickinson & Co              | Becton Dickinson & Co               | CUSIP: 075887109<br>LEI: ICE2EP6D98PQUILVRZ91 | Long             | EC               | CORP              | US        |       187 | NS      | $35000.79     | 1.75%             |  |  |  | No            |                  1 | On Loan: No      |
| Exact Sciences Corp                | Exact Sciences Corp                 | CUSIP: 30063P105<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |       850 | NS      | $46503.50     | 2.32%             |  |  |  | No            |                  1 | On Loan: No      |
| Globus Medical Inc                 | Globus Medical Inc                  | CUSIP: 379577208<br>LEI: 5299003M2P4CIK0RF205 | Long             | EC               | CORP              | US        |       524 | NS      | $30009.48     | 1.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Cochlear Ltd                       | Cochlear Ltd                        | CUSIP: 000000000<br>LEI: 5493001OLLWY8KV5UC08 | Long             | EC               | CORP              | AU        |       232 | NS      | $42868.86     | 2.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Merit Medical Systems Inc          | Merit Medical Systems Inc           | CUSIP: 589889104<br>LEI: 549300OYTY138SP2CE83 | Long             | EC               | CORP              | US        |       406 | NS      | $33791.38     | 1.69%             |  |  |  | No            |                  1 | On Loan: No      |
| Coloplast A/S                      | Coloplast A/S                       | CUSIP: 000000000<br>LEI: 529900NN7SOJ5QG82X67 | Long             | EC               | CORP              | DK        |       360 | NS      | $30745.28     | 1.54%             |  |  |  | No            |                  1 | On Loan: No      |
| Align Technology Inc               | Align Technology Inc                | CUSIP: 016255101<br>LEI: 549300N5YSE0U3LCP840 | Long             | EC               | CORP              | US        |       232 | NS      | $29051.04     | 1.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Koninklijke Philips NV             | Koninklijke Philips NV              | CUSIP: 000000000<br>LEI: H1FJE8H61JGM1JSGM897 | Long             | EC               | CORP              | NL        |      1655 | NS      | $44768.07     | 2.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Sysmex Corp                        | Sysmex Corp                         | CUSIP: 000000000<br>LEI: 5299001ZO4CKWACMZI55 | Long             | EC               | CORP              | JP        |      1934 | NS      | $23860.32     | 1.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Fisher & Paykel Healthcare Cor     | Fisher & Paykel Healthcare Corp Ltd | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | NZ        |      1881 | NS      | $40403.42     | 2.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Mettler-Toledo International I     | Mettler-Toledo International Inc    | CUSIP: 592688105<br>LEI: 5493000BD5GJNUDIUG10 | Long             | EC               | CORP              | US        |        37 | NS      | $45421.57     | 2.27%             |  |  |  | No            |                  1 | On Loan: No      |
| Straumann Holding AG               | Straumann Holding AG                | CUSIP: 000000000<br>LEI: 50670046ML5FVIM60Z37 | Long             | EC               | CORP              | CH        |       321 | NS      | $34235.16     | 1.71%             |  |  |  | No            |                  1 | On Loan: No      |
| Amplifon SpA                       | Amplifon SpA                        | CUSIP: 000000000<br>LEI: ZYXJDNVM2JI3VBM8G556 | Long             | EC               | CORP              | IT        |      1873 | NS      | $30467.18     | 1.52%             |  |  |  | No            |                  1 | On Loan: No      |
| West Pharmaceutical Services I     | West Pharmaceutical Services Inc    | CUSIP: 955306105<br>LEI: 5493007NKRGM1RJQ1P16 | Long             | EC               | CORP              | US        |       183 | NS      | $48006.39     | 2.40%             |  |  |  | No            |                  1 | On Loan: No      |
| Terumo Corp                        | Terumo Corp                         | CUSIP: 000000000<br>LEI: 353800JX1R4582QVK932 | Long             | EC               | CORP              | JP        |      1860 | NS      | $30726.44     | 1.54%             |  |  |  | No            |                  1 | On Loan: No      |
| Danaher Corp                       | Danaher Corp                        | CUSIP: 235851102<br>LEI: S4BKK9OTCEWQ3YHPFM11 | Long             | EC               | CORP              | US        |       206 | NS      | $40841.56     | 2.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Insulet Corp                       | Insulet Corp                        | CUSIP: 45784P101<br>LEI: 549300TZTYD2PYN92D43 | Long             | EC               | CORP              | US        |       148 | NS      | $45692.04     | 2.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Smith & Nephew PLC                 | Smith & Nephew PLC                  | CUSIP: 000000000<br>LEI: 213800ZTMDN8S67S1H61 | Long             | EC               | CORP              | GB        |      2997 | NS      | $53910.13     | 2.69%             |  |  |  | No            |                  1 | On Loan: No      |
| Medtronic PLC                      | Medtronic PLC                       | CUSIP: 000000000<br>LEI: 549300GX3ZBSQWUXY261 | Long             | EC               | CORP              | IE        |       451 | NS      | $42953.24     | 2.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Revvity Inc                        | Revvity Inc                         | CUSIP: 714046109<br>LEI: 549300IKL1SDPFI7N655 | Long             | EC               | CORP              | US        |       400 | NS      | $35060.00     | 1.75%             |  |  |  | No            |                  1 | On Loan: No      |
| Sonova Holding AG                  | Sonova Holding AG                   | CUSIP: 000000000<br>LEI: 5299004A0QNX7FBNHS61 | Long             | EC               | CORP              | CH        |       132 | NS      | $35916.34     | 1.80%             |  |  |  | No            |                  1 | On Loan: No      |
| Waters Corp                        | Waters Corp                         | CUSIP: 941848103<br>LEI: 5T547R1474YC9HOD8Q74 | Long             | EC               | CORP              | US        |       118 | NS      | $35377.58     | 1.77%             |  |  |  | No            |                  1 | On Loan: No      |
| Edwards Lifesciences Corp          | Edwards Lifesciences Corp           | CUSIP: 28176E108<br>LEI: YA13X31F3V31L8TMPR58 | Long             | EC               | CORP              | US        |       545 | NS      | $42384.65     | 2.12%             |  |  |  | No            |                  1 | On Loan: No      |
| ResMed Inc                         | ResMed Inc                          | CUSIP: 761152107<br>LEI: 529900T3QE5253CCXF22 | Long             | EC               | CORP              | US        |       177 | NS      | $48450.21     | 2.42%             |  |  |  | No            |                  1 | On Loan: No      |
| GE HealthCare Technologies Inc     | GE HealthCare Technologies Inc      | CUSIP: 36266G107<br>LEI: 549300OI9J7XOWZMUN85 | Long             | EC               | CORP              | US        |       597 | NS      | $44834.70     | 2.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Carl Zeiss Meditec AG              | Carl Zeiss Meditec AG               | CUSIP: 000000000<br>LEI: 529900GRL4MZ8NMOOK95 | Long             | EC               | CORP              | DE        |       624 | NS      | $30886.81     | 1.54%             |  |  |  | No            |                  1 | On Loan: No      |
| Zimmer Biomet Holdings Inc         | Zimmer Biomet Holdings Inc          | CUSIP: 98956P102<br>LEI: 2P2YLDVPES3BXQ1FRB91 | Long             | EC               | CORP              | US        |       364 | NS      | $35854.00     | 1.79%             |  |  |  | No            |                  1 | On Loan: No      |
| Penumbra Inc                       | Penumbra Inc                        | CUSIP: 70975L107<br>LEI: 549300RGE06P3ECANU72 | Long             | EC               | CORP              | US        |       138 | NS      | $34958.16     | 1.75%             |  |  |  | No            |                  1 | On Loan: No      |
| Masimo Corp                        | Masimo Corp                         | CUSIP: 574795100<br>LEI: 549300Q4A8JK0PIYCU29 | Long             | EC               | CORP              | US        |       246 | NS      | $36297.30     | 1.81%             |  |  |  | No            |                  1 | On Loan: No      |
| BioMerieux                         | BioMerieux                          | CUSIP: 000000000<br>LEI: 549300AK8Y0LBIQ4T071 | Long             | EC               | CORP              | FR        |       303 | NS      | $40483.01     | 2.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Sartorius Stedim Biotech           | Sartorius Stedim Biotech            | CUSIP: 000000000<br>LEI: 52990006IVXY7GCSSR39 | Long             | EC               | CORP              | FR        |       212 | NS      | $42823.13     | 2.14%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2025-11-24

**Name of Applicant:** First Trust Exchange-Traded Fund VI

**Signature:** Derek Maltbie

**Name of Signer:** Derek Maltbie

**Title:** Treasurer, Chief Financial Officer and Chief Accounting Officer