# EDGAR Filing Document

**Accession Number:** 0001162194
**File Stem:** 0000919574-25-007210
**Filing Date:** 2025-11
**Character Count:** 36231
**Document Hash:** 3c4db3d12e41dfe9c39af3c6a6e6f087
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000919574-25-007210.hdr.sgml**: 20251128

**ACCESSION NUMBER**: 0000919574-25-007210

**CONFORMED SUBMISSION TYPE**: SCHEDULE 13D/A

**PUBLIC DOCUMENT COUNT**: 3

**FILED AS OF DATE**: 20251128

**DATE AS OF CHANGE**: 20251128

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** STANDARD BIOTOOLS INC.
- **CENTRAL INDEX KEY:** 0001162194
- **STANDARD INDUSTRIAL CLASSIFICATION:** LABORATORY ANALYTICAL INSTRUMENTS [3826]
- **ORGANIZATION NAME:** 08 Industrial Applications and Services
- **EIN:** 770513190
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SCHEDULE 13D/A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-86635
- **FILM NUMBER:** 251536581

**BUSINESS ADDRESS:**
- **STREET 1:** 2 TOWER PLACE
- **STREET 2:** SUITE 2000
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080
- **BUSINESS PHONE:** 6502666000

**MAIL ADDRESS:**
- **STREET 1:** 2 TOWER PLACE
- **STREET 2:** SUITE 2000
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** FLUIDIGM CORP
- **DATE OF NAME CHANGE:** 20011113
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Casdin Capital, LLC
- **CENTRAL INDEX KEY:** 0001534261

**ORGANIZATION NAME:**
- **EIN:** 800752351
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SCHEDULE 13D/A

**BUSINESS ADDRESS:**
- **STREET 1:** 1350 AVENUE OF THE AMERICAS
- **STREET 2:** SUITE 2600
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10019
- **BUSINESS PHONE:** 212.300.5575

**MAIL ADDRESS:**
- **STREET 1:** 1350 AVENUE OF THE AMERICAS
- **STREET 2:** SUITE 2600
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10019

## Ex-99

Exhibit A

<u>AGREEMENT</u>

The undersigned agree that this Schedule 13D amendment, dated November 28, 2025, relating to the Common Stock, $0.001 par value per share, of Standard BioTools Inc. shall be filed on behalf of the undersigned.

<u>November 28, 2025</u> <br> (Date)

---

| |
|:---|
| &nbsp;&nbsp; Casdin Private Growth Equity Fund II, L.P<br> By: Casdin Private Growth Equity Fund II GP, LLC<br>By: /s/ Eli Casdin |
| &nbsp;&nbsp;(Signature) |
| &nbsp;&nbsp;Eli Casdin, Managing Member |
| &nbsp;&nbsp;(Name/Title) |
| &nbsp;&nbsp; Casdin Private Growth Equity Fund II GP, LLC<br>By: /s/ Eli Casdin |
| &nbsp;&nbsp;(Signature) |
| &nbsp;&nbsp;Eli Casdin, Managing Member |
| &nbsp;&nbsp;(Name/Title) |
| &nbsp;&nbsp; Casdin Capital, LLC<br>By: /s/ Eli Casdin |
| &nbsp;&nbsp;(Signature) |
| &nbsp;&nbsp;Eli Casdin, Managing Member |
| &nbsp;&nbsp;(Name/Title) |

---

---

| |
|:---|
| &nbsp;&nbsp; Casdin Partners Master Fund, L.P.<br> By: Casdin Partners GP, LLC, its general partner<br>By: /s/ Eli Casdin |
| &nbsp;&nbsp;(Signature) |
| &nbsp;&nbsp;Eli Casdin, Managing Member |
| &nbsp;&nbsp;(Name/Title) |

---

---

| |
|:---|
| &nbsp;&nbsp; Casdin Partners GP, LLC<br>By: /s/ Eli Casdin |
| &nbsp;&nbsp;(Signature) |
| &nbsp;&nbsp;Eli Casdin, Managing Member |
| &nbsp;&nbsp;(Name/Title) |
| &nbsp;&nbsp;/s/ Eli Casdin |
| &nbsp;&nbsp; Eli Casdin<br>|

---

## Ex-99

Exhibit B

**Schedule of Transactions in Shares**

---

| | | | | |
|:---|:---|:---|:---|:---|
| &nbsp;&nbsp; <br> <u>Date of Transaction</u> | &nbsp;&nbsp; <br> <u>Title of Class</u> | &nbsp;&nbsp;<u>Number of Shares Acquired</u> | &nbsp;&nbsp;<u>Number of Shares Disposed</u> | &nbsp;&nbsp; <u>Price Per</u><br> <u>Share</u> |
| &nbsp;&nbsp;11/07/2025 | &nbsp;&nbsp;Common Stock | &nbsp;&nbsp;225000 |  | &nbsp;&nbsp;$1.1234 (1) |
| &nbsp;&nbsp;11/10/2025 | &nbsp;&nbsp;Common Stock | &nbsp;&nbsp;275000 |  | &nbsp;&nbsp;$1.1706 (2) |
| &nbsp;&nbsp;11/11/2025 | &nbsp;&nbsp;Common Stock | &nbsp;&nbsp;300000 |  | &nbsp;&nbsp;$1.196 (3) |
| &nbsp;&nbsp;11/12/2025 | &nbsp;&nbsp;Common Stock | &nbsp;&nbsp;375000 |  | &nbsp;&nbsp;$1.1889 (4) |
| &nbsp;&nbsp;11/13/2025 | &nbsp;&nbsp;Common Stock | &nbsp;&nbsp;450000 |  | &nbsp;&nbsp;$1.2031 (5) |
| &nbsp;&nbsp;11/14/2025 | &nbsp;&nbsp;Common Stock | &nbsp;&nbsp;250000 |  | &nbsp;&nbsp;$1.2392 (6) |
| &nbsp;&nbsp;11/17/2025 | &nbsp;&nbsp;Common Stock | &nbsp;&nbsp;225000 |  | &nbsp;&nbsp;$1.2248 (7) |
| &nbsp;&nbsp;11/18/2025 | &nbsp;&nbsp;Common Stock | &nbsp;&nbsp;275000 |  | &nbsp;&nbsp;$1.2342 (8) |
| &nbsp;&nbsp;11/19/2025 | &nbsp;&nbsp;Common Stock | &nbsp;&nbsp;350000 |  | &nbsp;&nbsp;$1.2826 (9) |
| &nbsp;&nbsp;11/20/2025 | &nbsp;&nbsp;Common Stock | &nbsp;&nbsp;450000 |  | &nbsp;&nbsp;$1.3028 (10) |
| &nbsp;&nbsp;11/24/2025 | &nbsp;&nbsp;Common Stock | &nbsp;&nbsp;150000 |  | &nbsp;&nbsp;$1.4325 (11) |
| &nbsp;&nbsp;11/25/2025 | &nbsp;&nbsp;Common Stock | &nbsp;&nbsp;7550000 |  | &nbsp;&nbsp;$1.3031 (12) |

---

(1) The price reported is a weighted average price. These Common Shares were bought in multiple transactions within the range of $1.1153 to $1.1321. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares bought at each separate price within the range set forth in this footnote.

(2) The price reported is a weighted average price. These Common Shares were bought in multiple transactions within the range of $1.1688 to $1.1732. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares bought at each separate price within the range set forth in this footnote.

(3) The price reported is a weighted average price. These Common Shares were bought in multiple transactions within the range of $1.1881 to $1.2053. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares bought at each separate price within the range set forth in this footnote.

(4) The price reported is a weighted average price. These Common Shares were bought in multiple transactions within the range of $1.1865 to $1.1913. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares bought at each separate price within the range set forth in this footnote.

(5) The price reported is a weighted average price. These Common Shares were bought in multiple transactions within the range of $1.1978 to $1.2098. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares bought at each separate price within the range set forth in this footnote.

(6) The price reported is a weighted average price. These Common Shares were bought in multiple transactions within the range of $1.2364 to $1.2434. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares bought at each separate price within the range set forth in this footnote.

(7) The price reported is a weighted average price. These Common Shares were bought in multiple transactions within the range of $1.2175 to $1.2299. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares bought at each separate price within the range set forth in this footnote.

(8) The price reported is a weighted average price. These Common Shares were bought in multiple transactions within the range of $1.2247 to $1.2421. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares bought at each separate price within the range set forth in this footnote.

(9) The price reported is a weighted average price. These Common Shares were bought in multiple transactions within the range of $1.2758 to $1.2870. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares bought at each separate price within the range set forth in this footnote.

(10) The price reported is a weighted average price. These Common Shares were bought in multiple transactions within the range of $1.2788 to $1.3500. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares bought at each separate price within the range set forth in this footnote.

(11) The price reported is a weighted average price. These Common Shares were bought in multiple transactions within the range of $1.4290 to $1.4396. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares bought at each separate price within the range set forth in this footnote.

(12) The price reported is a weighted average price. These Common Shares were bought in multiple transactions within the range of $1.30 to $1.3843. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares bought at each separate price within the range set forth in this footnote.

### UNITED STATES SECURITIES AND EXCHANGE COMMISSION
**Washington, D.C. 20549**

## SCHEDULE 13D

### Under the Securities Exchange Act of 1934

**(Amendment No. 7)**

**Standard BioTools Inc.**

*(Name of Issuer)*

**Common Stock, $0.001 par value per share**

*(Title of Class of Securities)*

**34385P108**

*(CUSIP Number)*

**Eli Casdin**<br>Casdin Capital, LLC<br>1350 Avenue of the Americas, Suite 2600<br>New York NY 10019<br>1-212-897-5430

*(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)*

**11/25/2025**

*(Date of Event Which Requires Filing of this Statement)*

| **CUSIP No.** | **34385P108** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**Casdin Capital, LLC** | Name of reporting person<br>**Casdin Capital, LLC** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**88433856.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**88433856.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**88433856.00** | Aggregate amount beneficially owned by each reporting person<br>**88433856.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**22.9%** | Percent of class represented by amount in Row (11)<br>**22.9%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**IA** | Type of Reporting Person (See Instructions)<br>**IA** | |

---

| **CUSIP No.** | **34385P108** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**Casdin Private Growth Equity Fund II, L.P.** | Name of reporting person<br>**Casdin Private Growth Equity Fund II, L.P.** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**WC** | Source of funds (See Instructions)<br>**WC** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**13939637.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**13939637.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**13939637.00** | Aggregate amount beneficially owned by each reporting person<br>**13939637.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**3.6%** | Percent of class represented by amount in Row (11)<br>**3.6%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**PN** | Type of Reporting Person (See Instructions)<br>**PN** | |

---

| **CUSIP No.** | **34385P108** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**Casdin Private Growth Equity Fund II GP, LLC** | Name of reporting person<br>**Casdin Private Growth Equity Fund II GP, LLC** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**13939637.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**13939637.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**13939637.00** | Aggregate amount beneficially owned by each reporting person<br>**13939637.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**3.6%** | Percent of class represented by amount in Row (11)<br>**3.6%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**OO** | Type of Reporting Person (See Instructions)<br>**OO** | |

---

| **CUSIP No.** | **34385P108** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**Casdin Partners Master Fund, L.P.** | Name of reporting person<br>**Casdin Partners Master Fund, L.P.** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**WC** | Source of funds (See Instructions)<br>**WC** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**CAYMAN ISLANDS** | Citizenship or place of organization<br>**CAYMAN ISLANDS** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**71750000.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**71750000.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**71750000.00** | Aggregate amount beneficially owned by each reporting person<br>**71750000.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**18.7%** | Percent of class represented by amount in Row (11)<br>**18.7%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**PN** | Type of Reporting Person (See Instructions)<br>**PN** | |

---

| **CUSIP No.** | **34385P108** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**Casdin Partners GP, LLC** | Name of reporting person<br>**Casdin Partners GP, LLC** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**71750000.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**71750000.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**71750000.00** | Aggregate amount beneficially owned by each reporting person<br>**71750000.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**18.7%** | Percent of class represented by amount in Row (11)<br>**18.7%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**OO** | Type of Reporting Person (See Instructions)<br>**OO** | |

---

| **CUSIP No.** | **34385P108** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**Eli Casdin** | Name of reporting person<br>**Eli Casdin** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**X1** | Citizenship or place of organization<br>**X1** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**5008931.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**88433856.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**5008931.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**88433856.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**93442787.00** | Aggregate amount beneficially owned by each reporting person<br>**93442787.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**24.2%** | Percent of class represented by amount in Row (11)<br>**24.2%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**IN** | Type of Reporting Person (See Instructions)<br>**IN** | |

---

**Item 1. Security and Issuer**

**(a) Title of Class of Securities:**
Common Stock, $0.001 par value per share

**(b) Name of Issuer:**
Standard BioTools Inc.

**(c) Address of Issuer's Principal Executive Offices:**
2 Tower Place, Suite 2000, South San Francisco, CA, 94080

The name of the issuer is Standard BioTools Inc., a Delaware corporation (the "Issuer").  The address of the Issuer's principal executive offices is 2 Tower Place, Suite 2000, South San Francisco, California 94080.  This Schedule 13D amendment relates to the Issuer's Common Stock, $0.001 par value per share (the "Shares").

**Item 4. Purpose of Transaction**

Eli Casdin is a member of the Board of Directors of the Issuer.

The Reporting Persons have acquired their shares of the Issuer for investment purposes. The Reporting Persons intend to review their holdings in the Issuer on a continuing basis and, depending upon the price and availability of the Issuer's securities, subsequent developments affecting the Issuer, the business prospects of the Issuer, general stock market and economic conditions, tax considerations, investment considerations and/or other factors deemed relevant, may consider increasing or decreasing their investments in the Issuer.

On January 5, 2024, the Issuer completed the previously announced merger pursuant to the Agreement and Plan of Merger, dated as of October 4, 2023 (the "Merger Agreement"), by and among the Issuer, SomaLogic, Inc., a Delaware corporation ("SomaLogic"), and Martis Merger Sub, Inc., a Delaware corporation and wholly owned subsidiary of the Issuer ("Merger Sub"). Pursuant to the Merger Agreement, Merger Sub merged with and into SomaLogic, with SomaLogic surviving as a wholly owned subsidiary of the Issuer (the "Merger").

At the consummation of the Merger, each issued and outstanding share of common stock of SomaLogic, par value $0.0001 per share ("SomaLogic Common Stock"), was converted into the right to receive 1.11 (the "Exchange Ratio") Shares, and cash in lieu of fractional shares.

In addition, as of the effective time of the Merger, the Issuer assumed each SomaLogic stock incentive plan, each outstanding option to purchase shares of SomaLogic Common Stock (the "Options") and each outstanding restricted stock unit convertible into shares of SomaLogic Common Stock (the "RSUs," and together with the Options, the "Equity Awards"), whether vested or unvested. Each such Equity Award assumed by the Issuer will continue to have, and be subject to, the same terms and conditions applicable to such Equity Award immediately prior to the effective time of the Merger, except that (A) each such Option will be exercisable for that number of Shares equal to the number of shares of SomaLogic Common Stock subject to such Option immediately prior to the effective time of the Merger multiplied by the Exchange Ratio and rounded down to the next nearest Share, (B) the exercise price per share will be the exercise price per share in effect for that Option immediately prior to the effective time of the Merger divided by the Exchange Ratio and rounded up to the next nearest cent and (C) each such RSU will vest for that number of Shares equal to the number of shares of SomaLogic Common Stock subject to such RSU immediately prior to the effective time of the Merger multiplied by the Exchange Ratio and rounded to the next nearest Share.

In addition, as of the effective time of the Merger, each SomaLogic warrant, each exercisable for one share of SomaLogic Common Stock, shall be treated in accordance with its terms.

The description of the Merger Agreement and related transactions (including, without limitation, the Merger) is subject and qualified in its entirety by reference to the full text of the Merger Agreement, a copy of which is incorporated herein by reference to Exhibit 2.1 of the 8-K filed by the Issuer on January 5, 2024.

Except as set forth in this Schedule 13D, none of the Reporting Persons have any plan or proposals that relate to or would result in any of the transactions described in subparagraphs (a) through (j) of Item 4 of Schedule 13D. However, each of the Reporting Persons reserves the right to change its plans at any time, as it deems appropriate, in light of its ongoing evaluation of (i) its business and liquidity objectives, (ii) the Issuer's financial condition, business, operations, competitive position, prospects and/or share price, (iii) industry, economic and/or securities markets conditions, (iv) alternative investment opportunities and (v) other relevant factors.

Without limiting the generality of the preceding sentence, each of the Reporting Persons reserves the right (subject to any applicable restrictions under law or contracts by which it is bound) to at any time or from time to time (A) purchase or otherwise acquire additional shares of Common Stock or other securities of the Issuer, or instruments convertible into or exercisable for any such securities (collectively, "Issuer Securities"), in the open market, in privately negotiated transactions or otherwise, (B) sell, transfer or otherwise dispose of Issuer Securities in public or private transactions, (C) acquire or write options contracts, or enter into derivatives or hedging transactions, relating to Issuer Securities, (D) pledge Issuer Securities to secure obligations of the Reporting Persons and/or (E) encourage (including, without limitation, through any designated or nominated member of the Issuer's board of directors (the "Board of Directors") and/or communications with directors, management and existing or prospective security holders, investors or lenders of the Issuer, existing or potential strategic partners, industry analysts and other investment and financing professionals) the Issuer to consider or explore the following: (i) sales or acquisitions of assets or businesses or extraordinary corporate transactions, such as a merger (including transactions in which affiliates of Reporting Persons may be proposed as acquirers or as a source of financing), (ii) changes to the Issuer's capitalization or dividend policy, (iii) changes to the present Board of Directors, including changes to the number or term of members of the Board of Directors or filling existing vacancies on the Board of Directors, (iv) changes to the Issuer's by-laws and (v) other changes to the Issuer's business or structure.

For avoidance of doubt, the Reporting Persons further reserve the right to act in concert with any other shareholders of the Issuer, or other persons, for a common purpose should it determine to do so, and/or to recommend courses of action to management and the shareholders of the Issuer.

**Item 5. Interest in Securities of the Issuer**

**(a)**
(a) - (e) As of the date hereof, Casdin may be deemed to be the beneficial owner of 88,433,856 Shares, constituting 22.9% of the Shares, based upon 384,565,414* Shares outstanding.

Casdin has the sole power to vote or direct the vote of 0 Shares; has the shared power to vote or direct the vote of 88,433,856 Shares; has the sole power to dispose or direct the disposition of 0 Shares; and had the shared power to dispose or direct the disposition of 88,433,856 Shares.

As of the date hereof, Casdin PGEII and Casdin PGEII GP may be deemed to be the beneficial owners of 13,939,637 Shares, constituting 3.6% of the Shares, based upon 384,565,414* Shares outstanding.  As of the date hereof Casdin PGEII and Casdin PGEII GP have ceased to be the beneficial owners of more than five percent of the Shares.

Casdin PGEII and Casdin PGEII GP have the sole power to vote or direct the vote of 0 Shares; have the shared power to vote or direct the vote of 13,939,637 Shares; have the sole power to dispose or direct the disposition of 0 Shares; and have the shared power to dispose or direct the disposition of 13,939,637 Shares.

As of the date hereof, Casdin GP may be deemed to be the beneficial owner of 71,750,000 Shares, constituting 18.7% of the Shares, based upon 384,565,414* Shares outstanding.

Casdin GP has the sole power to vote or direct the vote of 0 Shares; has the shared power to vote or direct the vote of 71,750,000 Shares; has the sole power to dispose or direct the disposition of 0 Shares; and had the shared power to dispose or direct the disposition of 71,750,000 Shares.

As of the date hereof, Casdin PMF may be deemed to be the beneficial owner of 71,750,000 Shares, constituting 18.7% of the Shares, based upon 384,565,414* Shares outstanding.

Casdin PMF has the sole power to vote or direct the vote of 0 Shares; has the shared power to vote or direct the vote of 71,750,000 Shares; has the sole power to dispose or direct the disposition of 0 Shares; and had the shared power to dispose or direct the disposition of 71,750,000 Shares.

As of the date hereof, Eli Casdin may be deemed to be the beneficial owner of 93,442,787 Shares, constituting 24.2% of the Shares, based upon 386,673,283** Shares outstanding.

Eli Casdin has the sole power to vote or direct the vote of 5,008,931 Shares; has the shared power to vote or direct the vote of 88,433,856 Shares; has the sole power to dispose or direct the disposition of 5,008,931 Shares; and had the shared power to dispose or direct the disposition of 88,433,856 Shares.

The transactions by the Reporting Persons in the securities of the Issuer during the past sixty days are set forth in Exhibit B.  All such transactions were carried out in open market transactions.

*This outstanding Shares figure reflects the 384,565,414 outstanding Shares as reported in the Form 10-Q filed by the Issuer on November 4, 2025.

*This outstanding Shares figure reflects the 384,565,414 outstanding Shares as reported in the Form 10-Q filed by the Issuer on November 4, 2025 and 2,107,869 options and warrants held by Eli Casdin.

**(b)**
—

**(c)**
—

**Item 6. Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer.**

Stock Purchase Agreement

On January 23, 2022, Casdin PMF and Casdin PGEII entered into the Series B-1 Convertible Preferred Stock Purchase Agreement (the "Stock Purchase Agreement") with the Issuer, pursuant to which the Issuer agreed to issue and sell (a) 78,750 shares of Series B-1 Preferred Stock to Casdin PMF in exchange for cash consideration of $78,750,000 and (b) 33,750 shares of Series B-1 Preferred Stock to Casdin PGEII in exchange for cash consideration of $33,750,000.

Loan Agreement

On January 23, 2022, the Issuer entered into a loan agreement (the "Loan Agreement"), dated and effective as of January 23, 2022, pursuant to which (a) Casdin PMF provided a term loan to the Issuer in an aggregate original principal amount of $8,750,000 and (b) Casdin PGEII provided a term loan to the Issuer in an aggregate original principal amount of $3,750,000.

The loans were fully drawn on January 24, 2022. Upon the issuance of the Series B-1 Preferred Stock pursuant to the Stock Purchase Agreement, the aggregate principal amount of the term loan and all unpaid interest owed to Casdin PMF was automatically converted into 10,696 shares of Series B-1 Preferred Stock and the aggregate principal amount of the term loan and all unpaid interest owed to Casdin PGEII was automatically converted into 4,584 shares of Series B-1 Preferred Stock, in each case in accordance with the terms of the Loan Agreement.

Exchange Agreement

On March 18, 2024, Casdin PMF and Casdin PGEII entered into an exchange agreement (the "Exchange Agreement") with the Issuer, pursuant to which (a) Casdin PMF exchanged 89,446 shares of Series B-1 Preferred Stock for 32,525,821 shares of Common Stock and (b) Casdin PGEII exchanged 38,334 shares of Series B-1 Preferred Stock for 13,939,637 shares of Common Stock

### SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** Casdin Capital, LLC

**Signature:** /s/ Eli Casdin*

**Name/Title:** Eli Casdin, Managing Member

**Date:** 11/28/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** Casdin Private Growth Equity Fund II, L.P.

**Signature:** By: Casdin Private Growth Equity Fund II GP, LLC, By: /s/ Eli Casdin*

**Name/Title:** Eli Casdin, Manager

**Date:** 11/28/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** Casdin Private Growth Equity Fund II GP, LLC

**Signature:** /s/ Eli Casdin*

**Name/Title:** Eli Casdin, Managing Member

**Date:** 11/28/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** Casdin Partners Master Fund, L.P.

**Signature:** By: Casdin Partners GP, LLC, its general partner, By: /s/ Eli Casdin

**Name/Title:** Eli Casdin, Managing Member

**Date:** 11/28/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** Casdin Partners GP, LLC

**Signature:** /s/ Eli Casdin*

**Name/Title:** Eli Casdin

**Date:** 11/28/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** Eli Casdin

**Signature:** /s/ Eli Casdin*

**Name/Title:** Eli Casdin

**Date:** 11/28/2025