# EDGAR Filing Document

**Accession Number:** 0001595725
**File Stem:** 0001172661-25-004882
**Filing Date:** 2025-11
**Character Count:** 13357
**Document Hash:** 0874be192003d90fc3b73371520ba937
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001172661-25-004882.hdr.sgml**: 20251114

**ACCESSION NUMBER**: 0001172661-25-004882

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20250930

**FILED AS OF DATE**: 20251114

**DATE AS OF CHANGE**: 20251114

**EFFECTIVENESS DATE**: 20251114

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Rock Springs Capital Management LP
- **CENTRAL INDEX KEY:** 0001595725

**ORGANIZATION NAME:**
- **EIN:** 800944416
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-16048
- **FILM NUMBER:** 251482265

**BUSINESS ADDRESS:**
- **STREET 1:** 650 SOUTH EXETER STREET
- **STREET 2:** SUITE 1070
- **CITY:** BALTIMORE
- **STATE:** MD
- **ZIP:** 21202
- **BUSINESS PHONE:** 4102200129

**MAIL ADDRESS:**
- **STREET 1:** 650 SOUTH EXETER STREET
- **STREET 2:** SUITE 1070
- **CITY:** BALTIMORE
- **STATE:** MD
- **ZIP:** 21202

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 09-30-2025

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** Rock Springs Capital Management LP<br>**Address:** 650 South Exeter Street<br>Suite 1070<br>Baltimore, MD 21202

**Form 13F File Number:** 028-16048

**CRD Number (if applicable):** 000168648

**SEC File Number (if applicable):** 801-78511

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Nnamdi Etoh<br>**Title:** Chief Financial Officer<br>**Phone:** 410-220-0129

**Signature, Place, and Date of Signing:**

/s/  Nnamdi Etoh  Baltimore, MD  11-14-2025<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 93

**Form 13F Information Table Value Total:** $1711523566

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| ACADIA HEALTHCARE COMPANY IN | COM | 00404A109 |  | 4209200 | 170000 | SH |  | SOLE |  | 170000 | 0 | 0 |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 |  | 8757687 | 4609309 | SH |  | SOLE |  | 4609309 | 0 | 0 |
| AGILON HEALTH INC | COM | 00857U107 |  | 7175289 | 6966300 | SH |  | SOLE |  | 6966300 | 0 | 0 |
| AGIOS PHARMACEUTICALS INC | COM | 00847X104 |  | 38475876 | 958542 | SH |  | SOLE |  | 958542 | 0 | 0 |
| AKERO THERAPEUTICS INC | COM | 00973Y108 |  | 29747454 | 626526 | SH |  | SOLE |  | 626526 | 0 | 0 |
| ALKERMES PLC | SHS | G01767105 |  | 3196110 | 106537 | SH |  | SOLE |  | 106537 | 0 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 |  | 33858000 | 74250 | SH |  | SOLE |  | 74250 | 0 | 0 |
| ALPHATEC HLDGS INC | COM NEW | 02081G201 |  | 4398350 | 302500 | SH |  | SOLE |  | 302500 | 0 | 0 |
| AMICUS THERAPEUTICS INC | COM | 03152W109 |  | 15345307 | 1947374 | SH |  | SOLE |  | 1947374 | 0 | 0 |
| AMYLYX PHARMACEUTICALS INC | COM | 03237H101 |  | 6791793 | 499764 | SH |  | SOLE |  | 499764 | 0 | 0 |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 |  | 2081960 | 92000 | SH |  | SOLE |  | 92000 | 0 | 0 |
| APPLIED THERAPEUTICS INC | COM | 03828A101 |  | 1255767 | 2075991 | SH |  | SOLE |  | 2075991 | 0 | 0 |
| ARCELLX INC | COMMON STOCK | 03940C100 |  | 14694422 | 178982 | SH |  | SOLE |  | 178982 | 0 | 0 |
| ARDELYX INC | COM | 039697107 |  | 12597364 | 2286273 | SH |  | SOLE |  | 2286273 | 0 | 0 |
| ARGENX SE | SPONSORED ADR | 04016X101 |  | 105286690 | 142750 | SH |  | SOLE |  | 142750 | 0 | 0 |
| ASCENDIS PHARMA A/S | SPONSORED ADR | 04351P101 |  | 42644745 | 214500 | SH |  | SOLE |  | 214500 | 0 | 0 |
| AZENTA INC | COM | 114340102 |  | 15520288 | 540400 | SH |  | SOLE |  | 540400 | 0 | 0 |
| BICARA THERAPEUTICS INC | COM | 055477103 |  | 5852816 | 370666 | SH |  | SOLE |  | 370666 | 0 | 0 |
| BOSTON SCIENTIFIC CORP | COM | 101137107 |  | 35171208 | 360250 | SH |  | SOLE |  | 360250 | 0 | 0 |
| BRIDGEBIO PHARMA INC | COM | 10806X102 |  | 4414900 | 85000 | SH |  | SOLE |  | 85000 | 0 | 0 |
| CARIS LIFE SCIENCES INC | COM | 142152107 |  | 24007943 | 793651 | SH |  | SOLE |  | 793651 | 0 | 0 |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 |  | 18666188 | 721538 | SH |  | SOLE |  | 721538 | 0 | 0 |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 |  | 1679070 | 69240 | SH |  | SOLE |  | 69240 | 0 | 0 |
| CHARLES RIV LABS INTL INC | COM | 159864107 |  | 422442 | 2700 | SH |  | SOLE |  | 2700 | 0 | 0 |
| CIDARA THERAPEUTICS INC | COM NEW | 171757206 |  | 23882736 | 249402 | SH |  | SOLE |  | 249402 | 0 | 0 |
| COGENT BIOSCIENCES INC | COM | 19240Q201 |  | 14479303 | 1008308 | SH |  | SOLE |  | 1008308 | 0 | 0 |
| COMPASS THERAPEUTICS INC | COM | 20454B104 |  | 15661457 | 4474702 | SH |  | SOLE |  | 4474702 | 0 | 0 |
| COMPUGEN LTD | ORD | M25722105 |  | 19742 | 13430 | SH |  | SOLE |  | 13430 | 0 | 0 |
| DANAHER CORPORATION | COM | 235851102 |  | 12192990 | 61500 | SH |  | SOLE |  | 61500 | 0 | 0 |
| DEXCOM INC | COM | 252131107 |  | 21324201 | 316900 | SH |  | SOLE |  | 316900 | 0 | 0 |
| DYNE THERAPEUTICS INC | COM | 26818M108 |  | 10424372 | 824061 | SH |  | SOLE |  | 824061 | 0 | 0 |
| EDAP TMS S A | SPONSORED ADR | 268311107 |  | 2908300 | 1270000 | SH |  | SOLE |  | 1270000 | 0 | 0 |
| EDWARDS LIFESCIENCES CORP | COM | 28176E108 |  | 6843760 | 88000 | SH |  | SOLE |  | 88000 | 0 | 0 |
| ELI LILLY  CO | COM | 532457108 |  | 80420200 | 105400 | SH |  | SOLE |  | 105400 | 0 | 0 |
| ENLIVEN THERAPEUTICS INC | COM | 29337E102 |  | 14044610 | 686107 | SH |  | SOLE |  | 686107 | 0 | 0 |
| EVOLENT HEALTH INC | CL A | 30050B101 |  | 24957000 | 2950000 | SH |  | SOLE |  | 2950000 | 0 | 0 |
| EXACT SCIENCES CORP | COM | 30063P105 |  | 32470385 | 593500 | SH |  | SOLE |  | 593500 | 0 | 0 |
| EYEPOINT PHARMACEUTICALS INC | COM NEW | 30233G209 |  | 450767 | 31655 | SH |  | SOLE |  | 31655 | 0 | 0 |
| GOSSAMER BIO INC | NOTE 5.000% 6/0 | 38341PAA0 |  | 6718513 | 9573000 | PRN |  | SOLE |  | 9573000 | 0 | 0 |
| GOSSAMER BIO INC | COM | 38341P102 |  | 8592105 | 3266960 | SH |  | SOLE |  | 3266960 | 0 | 0 |
| HEARTFLOW INC | COM | 42238D107 |  | 8415000 | 250000 | SH |  | SOLE |  | 250000 | 0 | 0 |
| IMMUNOVANT INC | COM | 45258J102 |  | 1176196 | 72965 | SH |  | SOLE |  | 72965 | 0 | 0 |
| INSMED INC | COM PAR $.01 | 457669307 |  | 55443850 | 385000 | SH |  | SOLE |  | 385000 | 0 | 0 |
| INSPIRE MED SYS INC | COM | 457730109 |  | 8199100 | 110500 | SH |  | SOLE |  | 110500 | 0 | 0 |
| INTUITIVE SURGICAL INC | COM NEW | 46120E602 |  | 36672860 | 82000 | SH |  | SOLE |  | 82000 | 0 | 0 |
| IRHYTHM TECHNOLOGIES INC | COM | 450056106 |  | 40417650 | 235000 | SH |  | SOLE |  | 235000 | 0 | 0 |
| JANUX THERAPEUTICS INC | COM | 47103J105 |  | 5141345 | 210366 | SH |  | SOLE |  | 210366 | 0 | 0 |
| JASPER THERAPEUTICS INC | COM NEW | 471871202 |  | 2619728 | 1100726 | SH |  | SOLE |  | 1100726 | 0 | 0 |
| KORRO BIO INC | COM | 500946108 |  | 1710583 | 35719 | SH |  | SOLE |  | 35719 | 0 | 0 |
| KYMERA THERAPEUTICS INC | COM | 501575104 |  | 25491168 | 450374 | SH |  | SOLE |  | 450374 | 0 | 0 |
| LENZ THERAPEUTICS INC | COM | 52635N103 |  | 11003454 | 236227 | SH |  | SOLE |  | 236227 | 0 | 0 |
| MADRIGAL PHARMACEUTICALS INC | COM | 558868105 |  | 63178580 | 137746 | SH |  | SOLE |  | 137746 | 0 | 0 |
| MBX BIOSCIENCES INC | COM | 55287L101 |  | 4945920 | 282624 | SH |  | SOLE |  | 282624 | 0 | 0 |
| MEREO BIOPHARMA GROUP PLC | SPON ADS | 589492107 |  | 9415537 | 4570649 | SH |  | SOLE |  | 4570649 | 0 | 0 |
| MERSANA THERAPEUTICS INC | COM | 59045L205 |  | 1184067 | 152586 | SH |  | SOLE |  | 152586 | 0 | 0 |
| MERUS N V | COM | N5749R100 |  | 56212352 | 597051 | SH |  | SOLE |  | 597051 | 0 | 0 |
| MINERALYS THERAPEUTICS INC | COM | 603170101 |  | 15483229 | 408313 | SH |  | SOLE |  | 408313 | 0 | 0 |
| MIRUM PHARMACEUTICALS INC | COM | 604749101 |  | 55798147 | 761126 | SH |  | SOLE |  | 761126 | 0 | 0 |
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 |  | 202194 | 28200 | SH |  | SOLE |  | 28200 | 0 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 |  | 12599105 | 89750 | SH |  | SOLE |  | 89750 | 0 | 0 |
| NEUROGENE INC | COM | 64135M105 |  | 1808195 | 104339 | SH |  | SOLE |  | 104339 | 0 | 0 |
| NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | N62509109 |  | 898704 | 31600 | SH | Call | SOLE |  | 31600 | 0 | 0 |
| NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | N62509109 |  | 16948221 | 595929 | SH |  | SOLE |  | 595929 | 0 | 0 |
| NOVAVAX INC | COM NEW | 670002401 |  | 390150 | 45000 | SH |  | SOLE |  | 45000 | 0 | 0 |
| NUVATION BIO INC | *W EXP 02/10/202 | 67080N119 |  | 27087 | 134028 | SH |  | SOLE |  | 134028 | 0 | 0 |
| OCULAR THERAPEUTIX INC | COM | 67576A100 |  | 3507000 | 300000 | SH |  | SOLE |  | 300000 | 0 | 0 |
| OMADA HEALTH INC | COM | 68170A108 |  | 20340095 | 919950 | SH |  | SOLE |  | 919950 | 0 | 0 |
| PENUMBRA INC | COM | 70975L107 |  | 30525060 | 120500 | SH |  | SOLE |  | 120500 | 0 | 0 |
| PERSPECTIVE THERAPEUTICS INC | COM NEW | 46489V302 |  | 1524234 | 444383 | SH |  | SOLE |  | 444383 | 0 | 0 |
| PHARVARIS N V | COM | N69605108 |  | 15553880 | 623402 | SH |  | SOLE |  | 623402 | 0 | 0 |
| PHREESIA INC | COM | 71944F106 |  | 17619208 | 749116 | SH |  | SOLE |  | 749116 | 0 | 0 |
| PROTHENA CORP PLC | SHS | G72800108 |  | 247884 | 25398 | SH |  | SOLE |  | 25398 | 0 | 0 |
| REGENERON PHARMACEUTICALS | COM | 75886F107 |  | 6353651 | 11300 | SH |  | SOLE |  | 11300 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 62357109 | 1335270 | SH |  | SOLE |  | 1335270 | 0 | 0 |
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 |  | 72420131 | 717102 | SH |  | SOLE |  | 717102 | 0 | 0 |
| SCHOLAR ROCK HLDG CORP | COM | 80706P103 |  | 29573513 | 794133 | SH |  | SOLE |  | 794133 | 0 | 0 |
| SIONNA THERAPEUTICS INC | COM | 829401108 |  | 2924207 | 99429 | SH |  | SOLE |  | 99429 | 0 | 0 |
| SOLENO THERAPEUTICS INC | COM | 834203309 |  | 10446093 | 154528 | SH |  | SOLE |  | 154528 | 0 | 0 |
| SPDR SERIES TRUST | S BIOTECH | 78464A870 |  | 15205350 | 151750 | SH |  | SOLE |  | 151750 | 0 | 0 |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 |  | 26632312 | 951154 | SH |  | SOLE |  | 951154 | 0 | 0 |
| SUMMIT THERAPEUTICS INC | COM | 86627T108 |  | 14668600 | 710000 | SH |  | SOLE |  | 710000 | 0 | 0 |
| TALPHERA INC | COM NEW | 00444T209 |  | 3205861 | 3589186 | SH |  | SOLE |  | 3589186 | 0 | 0 |
| TARSUS PHARMACEUTICALS INC | COM | 87650L103 |  | 17136284 | 288344 | SH |  | SOLE |  | 288344 | 0 | 0 |
| TENET HEALTHCARE CORP | COM NEW | 88033G407 |  | 25380000 | 125000 | SH |  | SOLE |  | 125000 | 0 | 0 |
| THERMO FISHER SCIENTIFIC INC | COM | 883556102 |  | 4850200 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| TRAVERE THERAPEUTICS INC | COM | 89422G107 |  | 51738075 | 2164773 | SH |  | SOLE |  | 2164773 | 0 | 0 |
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 |  | 37489937 | 1246341 | SH |  | SOLE |  | 1246341 | 0 | 0 |
| VAXCYTE INC | COM | 92243G108 |  | 399822 | 11100 | SH |  | SOLE |  | 11100 | 0 | 0 |
| VERA THERAPEUTICS INC | CL A | 92337R101 |  | 17941528 | 617396 | SH |  | SOLE |  | 617396 | 0 | 0 |
| WEST PHARMACEUTICAL SVSC INC | COM | 955306105 |  | 2557718 | 9750 | SH |  | SOLE |  | 9750 | 0 | 0 |
| XENON PHARMACEUTICALS INC | COM | 98420N105 |  | 34197522 | 851744 | SH |  | SOLE |  | 851744 | 0 | 0 |
| ZAI LAB LTD | ADR | 98887Q104 |  | 26813531 | 791193 | SH |  | SOLE |  | 791193 | 0 | 0 |
| ZENAS BIOPHARMA INC | COM | 98937L105 |  | 12891029 | 580677 | SH |  | SOLE |  | 580677 | 0 | 0 |

---