# EDGAR Filing Document

**Accession Number:** 0001604950
**File Stem:** 0001104659-23-021525
**Filing Date:** 2023-2
**Character Count:** 61951
**Document Hash:** 12a4d3ee501238ab7cfa7f104be3affc
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-23-021525.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001104659-23-021525

**CONFORMED SUBMISSION TYPE**: SC 13G/A

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**GROUP MEMBERS**: 5AM CO-INVESTORS IV, L.P.

**GROUP MEMBERS**: 5AM OPPORTUNITIES I (GP), LLC

**GROUP MEMBERS**: 5AM OPPORTUNITIES I, L.P.

**GROUP MEMBERS**: 5AM PARTNERS IV, LLC

**GROUP MEMBERS**: ANDREW J. SCHWAB

**GROUP MEMBERS**: DR. JOHN D. DIEKMAN

**GROUP MEMBERS**: DR. KUSH PARMAR

**GROUP MEMBERS**: DR. SCOTT M. ROCKLAGE

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** scPharmaceuticals Inc.
- **CENTRAL INDEX KEY:** 0001604950
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 465184075
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G/A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-90193
- **FILM NUMBER:** 23628703

**BUSINESS ADDRESS:**
- **STREET 1:** 2400 DISTRICT AVENUE
- **STREET 2:** SUITE 310
- **CITY:** BURLINGTON
- **STATE:** MA
- **ZIP:** 01803
- **BUSINESS PHONE:** 617-517-0730

**MAIL ADDRESS:**
- **STREET 1:** 2400 DISTRICT AVENUE
- **STREET 2:** SUITE 310
- **CITY:** BURLINGTON
- **STATE:** MA
- **ZIP:** 01803
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** 5AM Ventures IV, L.P.
- **CENTRAL INDEX KEY:** 0001589315
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G/A

**BUSINESS ADDRESS:**
- **STREET 1:** 501 2ND STREET, SUITE 350
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94107
- **BUSINESS PHONE:** (415) 993-8565

**MAIL ADDRESS:**
- **STREET 1:** 501 2ND STREET, SUITE 350
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94107

---

| |
|:---|
| **UNITED STATES** |
| **SECURITIES AND EXCHANGE COMMISSION** |
| **Washington, D.C. 20549** |

---

**SCHEDULE 13G**

**Under the Securities Exchange Act of 1934<br> (Amendment No. 2)\***

**scPharmaceuticals Inc.**

(Name of Issuer)

**Common Stock, par value $0.0001 per share**

(Title of Class of Securities)

**810648 105**

(CUSIP Number)

**December 31, 2022**

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

◻ Rule 13d-1(b) <br> ⌧ Rule 13d-1(c) <br> ◻ Rule 13d-1(d)

\*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 |
|  | 1. | Names of Reporting Persons<br> 5AM Ventures IV, L.P. | Names of Reporting Persons<br> 5AM Ventures IV, L.P. | Names of Reporting Persons<br> 5AM Ventures IV, L.P. | Names of Reporting Persons<br> 5AM Ventures IV, L.P. |
|  | 2. | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) |
|  |  | (a) | (a) | ◻ | ◻ |
|  |  | (b) | (b) | ⌧(1) | ⌧(1) |
|  | 3. | SEC Use Only | SEC Use Only | SEC Use Only | SEC Use Only |
|  | 4. | Citizenship or Place of Organization <br> Delaware, United States of America | Citizenship or Place of Organization <br> Delaware, United States of America | Citizenship or Place of Organization <br> Delaware, United States of America | Citizenship or Place of Organization <br> Delaware, United States of America |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 5. | 5. | Sole Voting Power <br> 0 shares |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 6. | 6. | Shared Voting Power<br> 2,231,601 shares (2) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 7. | 7. | Sole Dispositive Power<br> 0 shares |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 8. | 8. | Shared Dispositive Power <br> 2,231,601 shares (2) |
|  | 9. | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 2,231,601 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 2,231,601 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 2,231,601 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 2,231,601 shares (2) |
|  | 10. | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ |
|  | 11. | Percent of Class Represented by Amount in Row (9)<br> 6.6% (3) | Percent of Class Represented by Amount in Row (9)<br> 6.6% (3) | Percent of Class Represented by Amount in Row (9)<br> 6.6% (3) | Percent of Class Represented by Amount in Row (9)<br> 6.6% (3) |
|  | 12. | Type of Reporting Person (See Instructions)<br> PN | Type of Reporting Person (See Instructions)<br> PN | Type of Reporting Person (See Instructions)<br> PN | Type of Reporting Person (See Instructions)<br> PN |

---

(1) This Schedule 13G is filed by 5AM Ventures
 IV, L.P., a Delaware limited partnership ("Ventures IV"), 5AM Co-Investors IV,
 L.P., a Delaware limited partnership ("Co-Investors IV"), 5AM Partners IV, LLC,
 a Delaware limited liability company ("Partners IV"), 5AM Opportunities I, L.P.,
 a Delaware limited partnership ("Opportunities"), 5AM Opportunities I (GP), LLC,
 a Delaware limited liability company ("Opportunities GP"), Dr. John D. Diekman
 ("Diekman"), Andrew J. Schwab ("Schwab"), Dr. Kush Parmar ("Parmar")
 and Dr. Scott M. Rocklage ("Rocklage") and together with Ventures IV, Co-Investors
 IV, Partners IV, Opportunities, Opportunities GP, Diekman, Schwab and Parmar, collectively,
 the "Reporting Persons"). The Reporting Persons expressly disclaim status as
 a "group" for purposes of this Schedule 13G.

(2) Partners IV serves as the sole general partner
 of Ventures IV. Diekman, Schwab and Rocklage are managing members of Partners IV and
 share voting and dispositive power over the shares held by Ventures IV. The information
 with respect to the ownership of the Common Stock by the Reporting Persons filing this statement
 on Schedule 13G is provided as of December 31, 2022.

(3) This percentage is calculated based on 34,022,121
 shares of Common Stock outstanding as of November 25, 2022 upon the closing of the Issuer's
 public offering, as reported in the prospectus supplement dated November 22, 2022 filed
 by the Issuer with the Securities and Exchange Commission (the "SEC") on November 23,
 2022.

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 |
|  | 1. | Names of Reporting Persons<br> 5AM Co-Investors IV, L.P. | Names of Reporting Persons<br> 5AM Co-Investors IV, L.P. | Names of Reporting Persons<br> 5AM Co-Investors IV, L.P. | Names of Reporting Persons<br> 5AM Co-Investors IV, L.P. |
|  | 2. | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) |
|  |  | (a) | (a) | ◻ | ◻ |
|  |  | (b) | (b) | ⌧(1) | ⌧(1) |
|  | 3. | SEC Use Only | SEC Use Only | SEC Use Only | SEC Use Only |
|  | 4. | Citizenship or Place of Organization <br> Delaware, United States of America | Citizenship or Place of Organization <br> Delaware, United States of America | Citizenship or Place of Organization <br> Delaware, United States of America | Citizenship or Place of Organization <br> Delaware, United States of America |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 5. | 5. | Sole Voting Power <br> 0 shares |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 6. | 6. | Shared Voting Power<br> 92,983 shares (2) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 7. | 7. | Sole Dispositive Power<br> 0 shares |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 8. | 8. | Shared Dispositive Power <br> 92,983 shares (2) |
|  | 9. | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 92,983 of Common Stock (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 92,983 of Common Stock (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 92,983 of Common Stock (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 92,983 of Common Stock (2) |
|  | 10. | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ |
|  | 11. | Percent of Class Represented by Amount in Row (9)<br> 0.3% (3) | Percent of Class Represented by Amount in Row (9)<br> 0.3% (3) | Percent of Class Represented by Amount in Row (9)<br> 0.3% (3) | Percent of Class Represented by Amount in Row (9)<br> 0.3% (3) |
|  | 12. | Type of Reporting Person (See Instructions)<br> PN | Type of Reporting Person (See Instructions)<br> PN | Type of Reporting Person (See Instructions)<br> PN | Type of Reporting Person (See Instructions)<br> PN |

---

(1) This Schedule 13G is filed by the Reporting
 Persons. The Reporting Persons expressly disclaim status as a "group" for purposes
 of this Schedule 13G.

(2) Partners IV serves as the sole general partner
 of Co-Investors IV. Diekman, Schwab and Rocklage are managing members of Partners IV and
 share voting and dispositive power over the shares held by Co-Investors IV. The information
 with respect to the ownership of the Common Stock by the Reporting Persons filing this statement
 on Schedule 13G is provided as of December 31, 2022.

(3) This percentage is calculated based on 34,022,121
 shares of Common Stock outstanding as of November 25, 2022 upon the closing of the Issuer's
 public offering, as reported in the prospectus supplement dated November 22, 2022 filed
 by the Issuer with the SEC on November 23, 2022.

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 |
|  | 1. | Names of Reporting Persons<br> 5AM Partners IV, LLC | Names of Reporting Persons<br> 5AM Partners IV, LLC | Names of Reporting Persons<br> 5AM Partners IV, LLC | Names of Reporting Persons<br> 5AM Partners IV, LLC |
|  | 2. | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) |
|  |  | (a) | (a) | ◻ | ◻ |
|  |  | (b) | (b) | ⌧ (1) | ⌧ (1) |
|  | 3. | SEC Use Only | SEC Use Only | SEC Use Only | SEC Use Only |
|  | 4. | Citizenship or Place of Organization <br> Delaware, United States of America | Citizenship or Place of Organization <br> Delaware, United States of America | Citizenship or Place of Organization <br> Delaware, United States of America | Citizenship or Place of Organization <br> Delaware, United States of America |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 5. | 5. | Sole Voting Power <br> 0 shares |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 6. | 6. | Shared Voting Power<br> 2,324,584 shares (2) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 7. | 7. | Sole Dispositive Power<br> 0 shares |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 8. | 8. | Shared Dispositive Power <br> 2,324,584 shares (2) |
|  | 9. | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 2,324,584 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 2,324,584 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 2,324,584 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 2,324,584 shares (2) |
|  | 10. | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ |
|  | 11. | Percent of Class Represented by Amount in Row (9)<br> 6.8% (3) | Percent of Class Represented by Amount in Row (9)<br> 6.8% (3) | Percent of Class Represented by Amount in Row (9)<br> 6.8% (3) | Percent of Class Represented by Amount in Row (9)<br> 6.8% (3) |
|  | 12. | Type of Reporting Person (See Instructions)<br> OO | Type of Reporting Person (See Instructions)<br> OO | Type of Reporting Person (See Instructions)<br> OO | Type of Reporting Person (See Instructions)<br> OO |

---

(1) This Schedule 13G is filed by the Reporting
 Persons. The Reporting Persons expressly disclaim status as a "group" for purposes
 of this Schedule 13G.

(2) Includes 2,231,601 shares of Common Stock
 held by Ventures IV and 92,983 shares of Common Stock held by Co-Investors IV. Partners
 IV serves as the sole general partner of Ventures IV and Co-Investors IV. Diekman,
 Schwab and Rocklage are managing members of Partners IV and share voting and dispositive
 power over the shares held by Ventures IV and Co-Investors IV. The information with
 respect to the ownership of the Common Stock by the Reporting Persons filing this statement
 on Schedule 13G is provided as of December 31, 2022.

(3) This percentage is calculated based on 34,022,121
 shares of Common Stock outstanding as of November 25, 2022 upon the closing of the Issuer's
 public offering, as reported in the prospectus supplement dated November 22, 2022 filed
 by the Issuer with the SEC on November 23, 2022.

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 |
|  | 1. | Names of Reporting Persons<br> 5AM Opportunities I, L.P. | Names of Reporting Persons<br> 5AM Opportunities I, L.P. | Names of Reporting Persons<br> 5AM Opportunities I, L.P. | Names of Reporting Persons<br> 5AM Opportunities I, L.P. |
|  | 2. | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) |
|  |  | (a) | (a) | ◻ | ◻ |
|  |  | (b) | (b) | ⌧(1) | ⌧(1) |
|  | 3. | SEC Use Only | SEC Use Only | SEC Use Only | SEC Use Only |
|  | 4. | Citizenship or Place of Organization <br> Delaware, United States of America | Citizenship or Place of Organization <br> Delaware, United States of America | Citizenship or Place of Organization <br> Delaware, United States of America | Citizenship or Place of Organization <br> Delaware, United States of America |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 5. | 5. | Sole Voting Power <br> 0 shares |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 6. | 6. | Shared Voting Power<br> 410,268 shares (2) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 7. | 7. | Sole Dispositive Power<br> 0 shares |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 8. | 8. | Shared Dispositive Power <br> 410,268 shares (2) |
|  | 9. | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 410,268 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 410,268 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 410,268 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 410,268 shares (2) |
|  | 10. | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ |
|  | 11. | Percent of Class Represented by Amount in Row (9)<br> 1.2% (3) | Percent of Class Represented by Amount in Row (9)<br> 1.2% (3) | Percent of Class Represented by Amount in Row (9)<br> 1.2% (3) | Percent of Class Represented by Amount in Row (9)<br> 1.2% (3) |
|  | 12. | Type of Reporting Person (See Instructions)<br> PN | Type of Reporting Person (See Instructions)<br> PN | Type of Reporting Person (See Instructions)<br> PN | Type of Reporting Person (See Instructions)<br> PN |

---

(1) This Schedule 13G is filed by the Reporting
 Persons. The Reporting Persons expressly disclaim status as a "group" for purposes
 of this Schedule 13G.

(2) Opportunities GP serves as the sole general
 partner of Opportunities. Schwab and Parmar are managing members of Opportunities GP
 and share voting and dispositive power over the shares held by Opportunities. The information
 with respect to the ownership of the Common Stock by the Reporting Persons filing this statement
 on Schedule 13G is provided as of December 31, 2022.

(3) This percentage is calculated based on 34,022,121
 shares of Common Stock outstanding as of November 25, 2022 upon the closing of the Issuer's
 public offering, as reported in the prospectus supplement dated November 22, 2022 filed
 by the Issuer with the SEC on November 23, 2022.

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 |
|  | 1. | Names of Reporting Persons<br> 5AM Opportunities I (GP), LLC | Names of Reporting Persons<br> 5AM Opportunities I (GP), LLC | Names of Reporting Persons<br> 5AM Opportunities I (GP), LLC | Names of Reporting Persons<br> 5AM Opportunities I (GP), LLC |
|  | 2. | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) |
|  |  | (a) | (a) | ◻ | ◻ |
|  |  | (b) | (b) | ⌧(1) | ⌧(1) |
|  | 3. | SEC Use Only | SEC Use Only | SEC Use Only | SEC Use Only |
|  | 4. | Citizenship or Place of Organization <br> Delaware, United States of America | Citizenship or Place of Organization <br> Delaware, United States of America | Citizenship or Place of Organization <br> Delaware, United States of America | Citizenship or Place of Organization <br> Delaware, United States of America |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 5. | 5. | Sole Voting Power <br> 0 shares |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 6. | 6. | Shared Voting Power<br> 410,268 shares (2) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 7. | 7. | Sole Dispositive Power<br> 0 shares |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 8. | 8. | Shared Dispositive Power <br> 410,268 shares (2) |
|  | 9. | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 410,268 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 410,268 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 410,268 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 410,268 shares (2) |
|  | 10. | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ |
|  | 11. | Percent of Class Represented by Amount in Row (9)<br> 1.2% (3) | Percent of Class Represented by Amount in Row (9)<br> 1.2% (3) | Percent of Class Represented by Amount in Row (9)<br> 1.2% (3) | Percent of Class Represented by Amount in Row (9)<br> 1.2% (3) |
|  | 12. | Type of Reporting Person (See Instructions)<br> OO | Type of Reporting Person (See Instructions)<br> OO | Type of Reporting Person (See Instructions)<br> OO | Type of Reporting Person (See Instructions)<br> OO |

---

(1) This Schedule 13G is filed by the Reporting
 Persons. The Reporting Persons expressly disclaim status as a "group" for purposes
 of this Schedule 13G.

(2) Includes 410,268 shares of Common Stock held
 by Opportunities. Opportunities GP serves as the sole general partner of Opportunities.
 Schwab and Parmar are managing members of Opportunities GP and share voting and dispositive
 power over the shares held by Opportunities. The information with respect to the ownership
 of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided
 as of December 31, 2022.

(3) This percentage is calculated based on 34,022,121
 shares of Common Stock outstanding as of November 25, 2022 upon the closing of the Issuer's
 public offering, as reported in the prospectus supplement dated November 22, 2022 filed
 by the Issuer with the SEC on November 23, 2022.

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 |
|  | 1. | Names of Reporting Persons<br> Dr. John D. Diekman | Names of Reporting Persons<br> Dr. John D. Diekman | Names of Reporting Persons<br> Dr. John D. Diekman | Names of Reporting Persons<br> Dr. John D. Diekman |
|  | 2. | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) |
|  |  | (a) | (a) | ◻ | ◻ |
|  |  | (b) | (b) | ⌧(1) | ⌧(1) |
|  | 3. | SEC Use Only | SEC Use Only | SEC Use Only | SEC Use Only |
|  | 4. | Citizenship or Place of Organization <br> United States of America | Citizenship or Place of Organization <br> United States of America | Citizenship or Place of Organization <br> United States of America | Citizenship or Place of Organization <br> United States of America |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 5. | 5. | Sole Voting Power <br> 0 shares |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 6. | 6. | Shared Voting Power<br> 2,324,584 shares (2) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 7. | 7. | Sole Dispositive Power<br> 0 shares |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 8. | 8. | Shared Dispositive Power <br> 2,324,584 shares (2) |
|  | 9. | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 2,324,584 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 2,324,584 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 2,324,584 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 2,324,584 shares (2) |
|  | 10. | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ |
|  | 11. | Percent of Class Represented by Amount in Row (9)<br> 6.8% (3) | Percent of Class Represented by Amount in Row (9)<br> 6.8% (3) | Percent of Class Represented by Amount in Row (9)<br> 6.8% (3) | Percent of Class Represented by Amount in Row (9)<br> 6.8% (3) |
|  | 12. | Type of Reporting Person (See Instructions)<br> IN | Type of Reporting Person (See Instructions)<br> IN | Type of Reporting Person (See Instructions)<br> IN | Type of Reporting Person (See Instructions)<br> IN |

---

(1) This Schedule 13G is filed by the Reporting
 Persons. The Reporting Persons expressly disclaim status as a "group" for purposes
 of this Schedule 13G.

(2) Includes 2,231,601 shares of Common Stock
 held by Ventures IV and 92,983 shares of Common Stock held by Co-Investors IV. Partners
 IV serves as the sole general partner of Ventures IV and Co-Investors IV. Diekman,
 Schwab and Rocklage are managing members of Partners IV and share voting and dispositive
 power over the shares held by Ventures IV and Co-Investors IV. The information with
 respect to the ownership of the Common Stock by the Reporting Persons filing this statement
 on Schedule 13G is provided as of December 31, 2022.

(3) This percentage is calculated based on 34,022,121
 shares of Common Stock outstanding as of November 25, 2022 upon the closing of the Issuer's
 public offering, as reported in the prospectus supplement dated November 22, 2022 filed
 by the Issuer with the SEC on November 23, 2022.

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 |
|  | 1. | Names of Reporting Persons<br> Andrew J. Schwab | Names of Reporting Persons<br> Andrew J. Schwab | Names of Reporting Persons<br> Andrew J. Schwab | Names of Reporting Persons<br> Andrew J. Schwab |
|  | 2. | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) |
|  |  | (a) | (a) | ◻ | ◻ |
|  |  | (b) | (b) | ⌧(1) | ⌧(1) |
|  | 3. | SEC Use Only | SEC Use Only | SEC Use Only | SEC Use Only |
|  | 4. | Citizenship or Place of Organization <br> United States of America | Citizenship or Place of Organization <br> United States of America | Citizenship or Place of Organization <br> United States of America | Citizenship or Place of Organization <br> United States of America |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 5. | 5. | Sole Voting Power <br> 0 shares |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 6. | 6. | Shared Voting Power<br> 2,734,852 shares (2) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 7. | 7. | Sole Dispositive Power<br> 0 shares |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 8. | 8. | Shared Dispositive Power <br> 2,734,852 shares (2) |
|  | 9. | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 2,734,852 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 2,734,852 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 2,734,852 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 2,734,852 shares (2) |
|  | 10. | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ |
|  | 11. | Percent of Class Represented by Amount in Row (9)<br> 8.0% (3) | Percent of Class Represented by Amount in Row (9)<br> 8.0% (3) | Percent of Class Represented by Amount in Row (9)<br> 8.0% (3) | Percent of Class Represented by Amount in Row (9)<br> 8.0% (3) |
|  | 12. | Type of Reporting Person (See Instructions)<br> IN | Type of Reporting Person (See Instructions)<br> IN | Type of Reporting Person (See Instructions)<br> IN | Type of Reporting Person (See Instructions)<br> IN |

---

(1) This Schedule 13G is filed by the Reporting
 Persons. The Reporting Persons expressly disclaim status as a "group" for purposes
 of this Schedule 13G.

(2) Includes 2,231,601 shares of Common Stock
 held by Ventures IV, 92,983 shares of Common Stock held by Co-Investors IV and 410,268 shares
 of Common Stock held by Opportunities. Partners IV serves as the sole general partner of
 Ventures IV and Co-Investors IV. Diekman, Schwab and Rocklage are managing members of Partners
 IV and share voting and dispositive power over the shares held by Ventures IV and Co-Investors
 IV. Opportunities GP serves as the sole general partner of Opportunities. Schwab and
 Parmar are managing members of Opportunities GP and share voting and dispositive power over
 the shares held by Opportunities. The information with respect to the ownership of the Common
 Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of December 31,
 2022.

(3) This percentage is calculated based on 34,022,121
 shares of Common Stock outstanding as of November 25, 2022 upon the closing of the Issuer's
 public offering, as reported in the prospectus supplement dated November 22, 2022 filed
 by the Issuer with the SEC on November 23, 2022.

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 |
|  | 1. | Names of Reporting Persons<br> Dr. Kush Parmar | Names of Reporting Persons<br> Dr. Kush Parmar | Names of Reporting Persons<br> Dr. Kush Parmar | Names of Reporting Persons<br> Dr. Kush Parmar |
|  | 2. | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) |
|  |  | (a) | (a) | ◻ | ◻ |
|  |  | (b) | (b) | ⌧(1) | ⌧(1) |
|  | 3. | SEC Use Only | SEC Use Only | SEC Use Only | SEC Use Only |
|  | 4. | Citizenship or Place of Organization <br> United States of America | Citizenship or Place of Organization <br> United States of America | Citizenship or Place of Organization <br> United States of America | Citizenship or Place of Organization <br> United States of America |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 5. | 5. | Sole Voting Power <br> 0 shares |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 6. | 6. | Shared Voting Power<br> 410,268 shares (2) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 7. | 7. | Sole Dispositive Power<br> 0 shares |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 8. | 8. | Shared Dispositive Power <br> 410,268 shares (2) |
|  | 9. | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 410,268 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 410,268 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 410,268 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 410,268 shares (2) |
|  | 10. | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ |
|  | 11. | Percent of Class Represented by Amount in Row (9)<br> 1.2% (3) | Percent of Class Represented by Amount in Row (9)<br> 1.2% (3) | Percent of Class Represented by Amount in Row (9)<br> 1.2% (3) | Percent of Class Represented by Amount in Row (9)<br> 1.2% (3) |
|  | 12. | Type of Reporting Person (See Instructions)<br> IN | Type of Reporting Person (See Instructions)<br> IN | Type of Reporting Person (See Instructions)<br> IN | Type of Reporting Person (See Instructions)<br> IN |

---

(1) This Schedule 13G is filed by the Reporting
 Persons. The Reporting Persons expressly disclaim status as a "group" for purposes
 of this Schedule 13G.

(2) Includes 410,268 shares of Common Stock held
 by Opportunities. Opportunities GP serves as the sole general partner of Opportunities.
 Schwab and Parmar are managing members of Opportunities GP and share voting and dispositive
 power over the shares held by Opportunities. The information with respect to the ownership
 of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided
 as of December 31, 2022.

(3) This percentage is calculated based on 34,022,121
 shares of Common Stock outstanding as of November 25, 2022 upon the closing of the Issuer's
 public offering, as reported in the prospectus supplement dated November 22, 2022 filed
 by the Issuer with the SEC on November 23, 2022.

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 | CUSIP No. 810648 105 |
|  | 1. | Names of Reporting Persons<br> Dr. Scott M. Rocklage | Names of Reporting Persons<br> Dr. Scott M. Rocklage | Names of Reporting Persons<br> Dr. Scott M. Rocklage | Names of Reporting Persons<br> Dr. Scott M. Rocklage |
|  | 2. | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) | Check the Appropriate Box if a Member of a Group (See Instructions) |
|  |  | (a) | (a) | ◻ | ◻ |
|  |  | (b) | (b) | ⌧(1) | ⌧(1) |
|  | 3. | SEC Use Only | SEC Use Only | SEC Use Only | SEC Use Only |
|  | 4. | Citizenship or Place of Organization <br> United States of America | Citizenship or Place of Organization <br> United States of America | Citizenship or Place of Organization <br> United States of America | Citizenship or Place of Organization <br> United States of America |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 5. | 5. | Sole Voting Power <br> 0 shares |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 6. | 6. | Shared Voting Power<br> 2,324,584 shares (2) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 7. | 7. | Sole Dispositive Power<br> 0 shares |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | | | |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 8. | 8. | Shared Dispositive Power <br> 2,324,584 shares (2) |
|  | 9. | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 2,324,584 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 2,324,584 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 2,324,584 shares (2) | Aggregate Amount Beneficially Owned by Each Reporting Person<br> 2,324,584 shares (2) |
|  | 10. | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) □ |
|  | 11. | Percent of Class Represented by Amount in Row (9)<br> 6.8% (3) | Percent of Class Represented by Amount in Row (9)<br> 6.8% (3) | Percent of Class Represented by Amount in Row (9)<br> 6.8% (3) | Percent of Class Represented by Amount in Row (9)<br> 6.8% (3) |
|  | 12. | Type of Reporting Person (See Instructions)<br> IN | Type of Reporting Person (See Instructions)<br> IN | Type of Reporting Person (See Instructions)<br> IN | Type of Reporting Person (See Instructions)<br> IN |

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(1) This Schedule 13G is filed by the Reporting
 Persons. The Reporting Persons expressly disclaim status as a "group" for purposes
 of this Schedule 13G.

(2) Includes 2,231,601 shares of Common Stock
 held by Ventures IV and 92,983 shares of Common Stock held by Co-Investors IV. Partners IV
 serves as the sole general partner of Ventures IV and Co-Investors IV. Diekman, Schwab and
 Rocklage are managing members of Partners IV and share voting and dispositive power over
 the shares held by Ventures IV and Co-Investors IV. The information with respect to the ownership
 of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided
 as of December 31, 2022.

(3) This percentage is calculated based on 34,022,121
 shares of Common Stock outstanding as of November 25, 2022 upon the closing of the Issuer's
 public offering, as reported in the prospectus supplement dated November 22, 2022 filed
 by the Issuer with the SEC on November 23, 2022.

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| | |
|:---|:---|
| **Item 1.** | **Item 1.** |
| (a) | Name of Issuer<br> scPharmaceuticals Inc. |
| (b) | Address of Issuer's Principal Executive Offices<br> 2400 District Avenue, Suite 310<br> Burlington, Massachusetts 01830 |
| **Item 2.** | **Item 2.** |
| (a) | Name of Person Filing<br> 5AM Ventures IV, L.P. ("Ventures IV")<br> 5AM Co-Investors IV, L.P. ("Co-Investors IV")<br> 5AM Partners IV, LLC ("Partners IV")<br> 5AM Opportunities I, L.P. ("Opportunites")<br> 5AM Opportunities I (GP), LLC ("Opportunities GP")<br> Dr. John D. Diekman ("Diekman")<br> Andrew J. Schwab ("Schwab")<br> Dr. Kush Parmar ("Parmar")<br> Dr. Scott M. Rocklage ("Rocklage") |
| (b) | Address of Principal Business Office or, if none, Residence<br> c/o 5AM Ventures<br> 501 Second Street, Suite 350<br> San Francisco, CA 94107 |
| (c) | Citizenship |

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| | | | |
|:---|:---|:---|:---|
| Entities: | 5AM Ventures IV, L.P. |  | Delaware |
|  | &nbsp;&nbsp;5AM Co-Investors IV, L.P. | &nbsp;&nbsp;- | &nbsp;&nbsp;Delaware |
|  | &nbsp;&nbsp;5AM Partners IV, LLC | &nbsp;&nbsp;- | &nbsp;&nbsp;Delaware |
|  | &nbsp;&nbsp;5AM Opportunities I, L.P. | &nbsp;&nbsp;- | &nbsp;&nbsp;Delaware |
|  | &nbsp;&nbsp;5AM Opportunities I (GP), LLC | &nbsp;&nbsp;- | &nbsp;&nbsp;Delaware |
| Individuals: | &nbsp;&nbsp;Diekman | &nbsp;&nbsp;- | &nbsp;&nbsp;United States of America |
|  | &nbsp;&nbsp;Schwab | &nbsp;&nbsp;- | &nbsp;&nbsp;United States of America |
|  | &nbsp;&nbsp;Parmar | &nbsp;&nbsp;- | &nbsp;&nbsp;United States of America |
|  | &nbsp;&nbsp;Rocklage | &nbsp;&nbsp;- | &nbsp;&nbsp;United States of America |

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| | | |
|:---|:---|:---|
|  | (d) | Title of Class of Securities<br> Common Stock |
|  | (e) | CUSIP Number<br> 810648 105 |
| **Item 3.** | **If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:** | **If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:** |
|  | Not applicable. | Not applicable. |

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**Item 4.** **Ownership**

Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

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| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| **Reporting Persons** | **Shares Held <br> Directly** | **Sole<br> Voting<br> Power** | **Shared <br> Voting<br> Power** | **Sole <br> Dispositive<br> Power** | **Shared <br> Dispositive<br> Power** | **Beneficial <br> Ownership** | **Percentage <br> of Class (6)** |
| Ventures IV (1) (3) | 2231601 |  | 2231601 |  | 2231601 | 2231601 | 6.6% |
| Co-Investors IV (2) (3) | 92983 |  | 92983 |  | 92983 | 92983 | 0.3% |
| Partners IV (1) (2) (3) |  |  | 2324584 |  | 2324584 | 2324584 | 6.8% |
| Opportunities (4) (5) | 410268 |  | 410268 |  | 410268 | 410268 | 1.2% |
| Opportunities GP (4) (5) |  |  | 410268 |  | 410268 | 410268 | 1.2% |
| Diekman (1) (2) (3) |  |  | 2324584 |  | 2324584 | 2324584 | 6.8% |
| Schwab (1) (2) (3) (4) (5) |  |  | 2734852 |  | 2734852 | 2734852 | 8.0% |
| Parmar (4) (5) |  |  | 410268 |  | 410268 | 410268 | 1.2% |
| Rocklage (1) (2) (3) (4) (5) |  |  | 2324584 |  | 2324584 | 2324584 | 6.8% |

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(1) Includes 2,231,601
 shares of Common Stock held by Ventures IV.

(2) Includes 92,983 shares of Common Stock
 held by Co-Investors IV.

(3) Partners IV serves as the sole general
 partner of Ventures IV and Co-Investors IV. Diekman, Schwab and Rocklage are managing members of Partners IV and share voting
 and dispositive power over the shares held by Ventures IV and Co-Investors IV.

(4) Includes 410,268 shares of Common Stock
 held by Opportunities.

(5) Opportunities GP serves as the sole general
 partner of Opportunities. Schwab and Parmar are managing members of Opportunities GP and share voting and dispositive power over
 the shares held by Opportunities.

(6) This percentage is calculated based on
 34,022,121 shares of Common Stock outstanding as of November 25, 2022 upon the closing of the Issuer's public offering,
 as reported in the prospectus supplement dated November 22, 2022 filed by the Issuer with the SEC on November 23, 2022.

**Item 5.** **Ownership of Five Percent or Less of a Class**

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following ☐.

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| | |
|:---|:---|
| **Item 6.** | **Ownership of More than Five Percent on Behalf of Another Person** |
|  | Not applicable. |

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| | |
|:---|:---|
| **Item 7.** | **Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person** |
|  | Not applicable. |

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| | |
|:---|:---|
| **Item 8.** | **Identification and Classification of Members of the Group** |
|  | Not applicable. |

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| | |
|:---|:---|
| **Item 9.** | **Notice of Dissolution of Group** |
|  | Not applicable. |

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| | |
|:---|:---|
| **Item 10.** | **Certification** |

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By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having such purpose or effect.

**Signature**

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Dated: February 14, 2022

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| | | | |
|:---|:---|:---|:---|
| 5AM Ventures IV, L.P. | 5AM Ventures IV, L.P. | 5AM Co-Investors IV, L.P. | 5AM Co-Investors IV, L.P. |
| By: | 5AM Partners IV, LLC | By: | 5AM Partners IV, LLC |
| its | General Partner | its | General Partner |
| By: | /s/ Andrew J. Schwab | By: | /s/ Andrew J. Schwab |
|  | Name: Andrew J. Schwab |  | Name: Andrew J. Schwab |
|  | Title: Managing Member |  | Title: Managing Member |
| 5AM Partners IV, LLC | 5AM Partners IV, LLC |  |  |
| By: | /s/ Andrew J. Schwab |  |  |
|  | Name: Andrew J. Schwab |  |  |
|  | Title: Managing Member |  |  |
| 5AM Opportunities I, L.P. | 5AM Opportunities I, L.P. | 5AM Opportunities I (GP), LLC | 5AM Opportunities I (GP), LLC |
| By: | 5AM Opportunities I (GP), LLC |  |  |
| its | General Partner |  |  |
| By: | /s/ Andrew J. Schwab | By: | /s/ Andrew J. Schwab |
|  | Name: Andrew J. Schwab |  | Name: Andrew J. Schwab |
|  | Title: Managing Member |  | Title: Managing Member |
|  | /s/ Dr. John D. Diekman |  | /s/ Andrew J. Schwab |
|  | Dr. John D. Diekman |  | Andrew J. Schwab |
|  | /s/ Dr. Kush Parmar |  | /s/ Dr. Scott M. Rocklage |
|  | Dr. Dr. Kush Parmar |  | Dr. Scott M. Rocklage |

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| | |
|:---|:---|
| | **ATTENTION** |
| **Intentional misstatements or omissions of fact constitute Federal Criminal Violations (See 18 U.S.C. 1001).** | **Intentional misstatements or omissions of fact constitute Federal Criminal Violations (See 18 U.S.C. 1001).** |

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**Exhibit(s)**:

A - Joint Filing Statement

EXHIBIT A

JOINT FILING STATEMENT

We, the undersigned, hereby express our agreement that the attached Schedule 13G (or any amendments thereto) relating to the

Common Stock of scPharmaceuticals Inc. is filed on behalf of each of us.

Dated: February 14, 2022

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| | | | |
|:---|:---|:---|:---|
| 5AM Ventures IV, L.P. | 5AM Ventures IV, L.P. | 5AM Co-Investors IV, L.P. | 5AM Co-Investors IV, L.P. |
| By: | 5AM Partners IV, LLC | By: | 5AM Partners IV, LLC |
| its | General Partner | its | General Partner |
| By: | /s/ Andrew J. Schwab | By: | /s/ Andrew J. Schwab |
|  | Name: Andrew J. Schwab |  | Name: Andrew J. Schwab |
|  | Title: Managing Member |  | Title: Managing Member |
| 5AM Partners IV, LLC | 5AM Partners IV, LLC |  |  |
| By: | /s/ Andrew J. Schwab |  |  |
|  | Name: Andrew J. Schwab |  |  |
|  | Title: Managing Member |  |  |
| 5AM Opportunities I, L.P. | 5AM Opportunities I, L.P. | 5AM Opportunities I (GP), LLC | 5AM Opportunities I (GP), LLC |
| By: | 5AM Opportunities I (GP), LLC |  |  |
| its | General Partner |  |  |
| By: | /s/ Andrew J. Schwab | By: | /s/ Andrew J. Schwab |
|  | Name: Andrew J. Schwab |  | Name: Andrew J. Schwab |
|  | Title: Managing Member |  | Title: Managing Member |
|  | /s/ Dr. John D. Diekman |  | /s/ Andrew J. Schwab |
|  | Dr. John D. Diekman |  | Andrew J. Schwab |
|  | /s/ Dr. Kush Parmar |  | /s/ Dr. Scott M. Rocklage |
|  | Dr. Dr. Kush Parmar |  | Dr. Scott M. Rocklage |

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