# EDGAR Filing Document

**Accession Number:** 0001782539
**File Stem:** 0001012975-26-000144
**Filing Date:** 2026-2
**Character Count:** 6955
**Document Hash:** 2f5d34be57d1207ae6df0839775abb70
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001012975-26-000144.hdr.sgml**: 20260213

**ACCESSION NUMBER**: 0001012975-26-000144

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20251231

**FILED AS OF DATE**: 20260213

**DATE AS OF CHANGE**: 20260213

**EFFECTIVENESS DATE**: 20260213

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Nan Fung Group Holdings Ltd
- **CENTRAL INDEX KEY:** 0001782539

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** D8

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-21371
- **FILM NUMBER:** 26633321

**BUSINESS ADDRESS:**
- **STREET 1:** 17TH FLOOR, AIRSIDE
- **STREET 2:** 2 CONCORDE ROAD
- **CITY:** KAI TAK
- **STATE:** K3
- **ZIP:** 00000
- **BUSINESS PHONE:** 852-2521-7417

**MAIL ADDRESS:**
- **STREET 1:** 17TH FLOOR, AIRSIDE
- **STREET 2:** 2 CONCORDE ROAD
- **CITY:** KAI TAK
- **STATE:** K3
- **ZIP:** 00000

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2025

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** Nan Fung Group Holdings Ltd<br>**Address:** 17TH FLOOR AIRSIDE<br>2 CONCORDE ROAD<br>KAI TAK, K3 00000

**Form 13F File Number:** 028-21371

**CRD Number (if applicable):** 000287988

**SEC File Number (if applicable):** 802-110211

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Tang Chun Wai Nelson<br>**Title:** Director<br>**Phone:** (852) 3108 3708

**Signature, Place, and Date of Signing:**

/s/ Tang Chun Wai Nelson  Kai Tak, K3  02-13-2026<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[ ] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[x] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 2

**Form 13F Information Table Entry Total:** 27

**Form 13F Information Table Value Total:** $111726254

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

|   No. | Name                                               | Form 13F File Number   | CRD Number   | SEC File Number   |
|---:|:---|:---|:---|:---|
|     1 | Pivotal bioVenture Partners Investment Advisor LLC | 028-20630              | 000287988    | 802-110211        |
|     2 | Pivotal bioVenture Partners Fund I U.G.P. Ltd      | 028-20631              |  |  |

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 |  | 2750703 | 102984 | SH |  | DFND | 12 | 102984 | 0 | 0 |
| ARGENX SE | SPONSORED ADR | 04016X101 |  | 2354660 | 2800 | SH |  | DFND | 12 | 2800 | 0 | 0 |
| ASCENDIS PHARMA A/S | SPONSORED ADR | 04351P101 |  | 2900064 | 13600 | SH |  | DFND | 12 | 13600 | 0 | 0 |
| BEONE MEDICINES LTD | SPONSORED ADS | 07725L102 |  | 4776501 | 15722 | SH |  | DFND | 12 | 15722 | 0 | 0 |
| BICYCLE THERAPEUTICS PLC | SPONSORED ADS | 088786108 |  | 488116 | 68943 | SH |  | DFND | 12 | 68943 | 0 | 0 |
| BOLT BIOTHERAPEUTICS INC | COM NEW | 097702203 |  | 319041 | 58347 | SH |  | DFND | 12 | 58347 | 0 | 0 |
| BOLT PROJS HLDGS INC | COM NEW | 09769B206 |  | 32437 | 40597 | SH |  | DFND | 12 | 40597 | 0 | 0 |
| CYBIN INC | COM NEW | 23256X407 |  | 3762800 | 460000 | SH |  | DFND | 12 | 460000 | 0 | 0 |
| ENTRADA THERAPEUTICS INC | COM | 29384C108 |  | 504563 | 49082 | SH |  | DFND | 12 | 49082 | 0 | 0 |
| EVOMMUNE INC | COM SHS | 30054Y107 |  | 24670468 | 1441032 | SH |  | DFND | 12 | 1441032 | 0 | 0 |
| HARMONY BIOSCIENCES HLDGS IN | COM | 413197104 |  | 1012174 | 27049 | SH |  | DFND | 12 | 27049 | 0 | 0 |
| INCYTE CORP | COM | 45337C102 |  | 5829603 | 59022 | SH |  | DFND | 12 | 59022 | 0 | 0 |
| ISHARES BITCOIN TRUST ETF | SHS BEN INT | 46438F101 |  | 792811 | 15968 | SH |  | DFND | 12 | 15968 | 0 | 0 |
| ISHARES ETHEREUM TR | SHS | 46438R105 |  | 1133814 | 50549 | SH |  | DFND | 12 | 50549 | 0 | 0 |
| KYMERA THERAPEUTICS INC | COM | 501575104 |  | 2402384 | 30875 | SH |  | DFND | 12 | 30875 | 0 | 0 |
| LB PHARMACEUTICALS INC | COM SHS | 50180M108 |  | 6678000 | 300000 | SH |  | DFND | 12 | 300000 | 0 | 0 |
| MADRIGAL PHARMACEUTICALS INC | COM | 558868105 |  | 6913540 | 11872 | SH |  | DFND | 12 | 11872 | 0 | 0 |
| MAPLIGHT THERAPEUTICS INC | COM | 56565P103 |  | 17060059 | 971253 | SH |  | DFND | 12 | 971253 | 0 | 0 |
| OCULIS HOLDING AG | ORDINARY SHARES | H5870P102 |  | 10278599 | 514702 | SH |  | DFND | 12 | 514702 | 0 | 0 |
| PROCORE TECHNOLOGIES INC | COM | 74275K108 |  | 3876969 | 53299 | SH |  | DFND | 12 | 53299 | 0 | 0 |
| RANI THERAPEUTICS HLDGS INC | COM CL A | 753018100 |  | 666338 | 493584 | SH |  | DFND | 12 | 493584 | 0 | 0 |
| RECURSION PHARMACEUTICALS IN | CL A | 75629V104 |  | 2434724 | 595287 | SH |  | DFND | 12 | 595287 | 0 | 0 |
| REPLIMUNE GROUP INC | COM | 76029N106 |  | 619349 | 63719 | SH |  | DFND | 12 | 63719 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 1533501 | 19253 | SH |  | DFND | 12 | 19253 | 0 | 0 |
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 |  | 5257805 | 49120 | SH |  | DFND | 12 | 49120 | 0 | 0 |
| ROCKET LAB CORP | COM | 773121108 |  | 266762 | 3824 | SH |  | DFND | 12 | 3824 | 0 | 0 |
| STANDARD BIOTOOLS INC | COM | 34385P108 |  | 2410469 | 1883179 | SH |  | DFND | 12 | 1883179 | 0 | 0 |

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