# EDGAR Filing Document

**Accession Number:** 0001389933
**File Stem:** 0001389933-23-000002
**Filing Date:** 2023-2
**Character Count:** 11747
**Document Hash:** 267ae139527b209c3990e50f52899352
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001389933-23-000002.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001389933-23-000002

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**EFFECTIVENESS DATE**: 20230214

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** DAFNA Capital Management LLC
- **CENTRAL INDEX KEY:** 0001389933
- **IRS NUMBER:** 364334068

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-12327
- **FILM NUMBER:** 23627118

**BUSINESS ADDRESS:**
- **STREET 1:** 10990 WILSHIRE BOULEVARD
- **STREET 2:** SUITE 1400
- **CITY:** LOS ANGELES
- **STATE:** CA
- **ZIP:** 90024
- **BUSINESS PHONE:** (310) 954-3200

**MAIL ADDRESS:**
- **STREET 1:** 10990 WILSHIRE BOULEVARD
- **STREET 2:** SUITE 1400
- **CITY:** LOS ANGELES
- **STATE:** CA
- **ZIP:** 90024

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2022

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** DAFNA Capital Management LLC<br>**Address:** 10990 WILSHIRE BOULEVARD<br>SUITE 1400<br>LOS ANGELES, CA 90024

**Form 13F File Number:** 028-12327

**CRD Number (if applicable):** 000129053

**SEC File Number (if applicable):** 801-62559

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Nathan Fischel<br>**Title:** CEO<br>**Phone:** 310-954-3200

**Signature, Place, and Date of Signing:**

Nathan Fischel  Los Angeles, CA  02-14-2023<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 1

**Form 13F Information Table Entry Total:** 79

**Form 13F Information Table Value Total:** $355054654

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

| No.   | Name           | Form 13F File Number   |
|:---|:---|:---|
|  | Fischel Nathan | 028-12328              |

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| 89BIO INC | COM | 282559103 |  | 4126722 | 324173 | SH |  | SOLE |  | 324173 | 0 | 0 |
| ACCURAY INC | COM | 004397105 |  | 2554728 | 1222358 | SH |  | SOLE |  | 1222358 | 0 | 0 |
| ACRIVON THERAPEUTICS INC | COMMON STOCK | 004890109 |  | 180265 | 15648 | SH |  | SOLE |  | 15648 | 0 | 0 |
| ADAPTIMMUNE THERAPEUTICS PLC | SPONDS ADR | 00653A107 |  | 512553 | 351064 | SH |  | SOLE |  | 351064 | 0 | 0 |
| ADICET BIO INC | COM | 007002108 |  | 5646093 | 631554 | SH |  | SOLE |  | 631554 | 0 | 0 |
| AFFIMED N V | COM | N01045108 |  | 850990 | 686282 | SH |  | SOLE |  | 686282 | 0 | 0 |
| ALECTOR INC | COM | 014442107 |  | 4914403 | 532438 | SH |  | SOLE |  | 532438 | 0 | 0 |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 |  | 4314993 | 83446 | SH |  | SOLE |  | 83446 | 0 | 0 |
| ARCUS BIOSCIENCES INC | COM | 03969F109 |  | 2941048 | 142217 | SH |  | SOLE |  | 142217 | 0 | 0 |
| ASCENDIS PHARMA A/S | SPONSORED ADR | 04351P101 |  | 15902792 | 130212 | SH |  | SOLE |  | 130212 | 0 | 0 |
| ATRICURE INC | COM | 04963C209 |  | 3196647 | 72029 | SH |  | SOLE |  | 72029 | 0 | 0 |
| AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 |  | 2234685 | 1176150 | SH |  | SOLE |  | 1176150 | 0 | 0 |
| AXOGEN INC | COM | 05463X106 |  | 3314388 | 332103 | SH |  | SOLE |  | 332103 | 0 | 0 |
| BICYCLE THERAPEUTICS PLC | SPONSORED ADS | 088786108 |  | 3617120 | 122200 | SH |  | SOLE |  | 122200 | 0 | 0 |
| BIOCRYST PHARMACEUTICALS INC | COM | 09058V103 |  | 2881480 | 251000 | SH |  | SOLE |  | 251000 | 0 | 0 |
| BIOHAVEN LTD | COM | G1110E107 |  | 5456408 | 393113 | SH |  | SOLE |  | 393113 | 0 | 0 |
| BIOMEA FUSION INC | COM | 09077A106 |  | 291889 | 34625 | SH |  | SOLE |  | 34625 | 0 | 0 |
| BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 |  | 175500 | 97500 | SH |  | SOLE |  | 97500 | 0 | 0 |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 |  | 11444705 | 261235 | SH |  | SOLE |  | 261235 | 0 | 0 |
| BRAINSWAY LTD | SPONSORED ADS | 10501L106 |  | 543400 | 220000 | SH |  | SOLE |  | 220000 | 0 | 0 |
| CARDIOVASCULAR SYSTEMS | COM | 141619106 |  | 3908777 | 286988 | SH |  | SOLE |  | 286988 | 0 | 0 |
| CENTURY THERAPEUTICS INC | COM | 15673T100 |  | 2438633 | 475367 | SH |  | SOLE |  | 475367 | 0 | 0 |
| CINCOR PHARMA INC | COM | 17240Y109 |  | 589920 | 48000 | SH |  | SOLE |  | 48000 | 0 | 0 |
| COMPASS THERAPEUTICS INC | COM | 20454B104 |  | 3028316 | 602051 | SH |  | SOLE |  | 602051 | 0 | 0 |
| COMPUGEN LTD | ORD | M25722105 |  | 146863 | 205202 | SH |  | SOLE |  | 205202 | 0 | 0 |
| CYMABAY THERAPEUTICS INC | COM | 23257D103 |  | 1072540 | 171059 | SH |  | SOLE |  | 171059 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 8430651 | 183995 | SH |  | SOLE |  | 183995 | 0 | 0 |
| DEXCOM INC | COM | 252131107 |  | 7649588 | 67552 | SH |  | SOLE |  | 67552 | 0 | 0 |
| DICE THERAPEUTICS INC | COM | 23345J104 |  | 3853200 | 123500 | SH |  | SOLE |  | 123500 | 0 | 0 |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 |  | 6855576 | 766843 | SH |  | SOLE |  | 766843 | 0 | 0 |
| FATE THERAPEUTICS INC | COM | 31189P102 |  | 5558985 | 550940 | SH |  | SOLE |  | 550940 | 0 | 0 |
| F-STAR THERAPEUTICS INC | COM | 30315R107 |  | 3645888 | 576881 | SH |  | SOLE |  | 576881 | 0 | 0 |
| GALAPAGOS NV | SPON ADR | 36315X101 |  | 2337717 | 52675 | SH |  | SOLE |  | 52675 | 0 | 0 |
| GENFIT S A | ADS | 372279109 |  | 868759 | 197940 | SH |  | SOLE |  | 197940 | 0 | 0 |
| IDEAYA BIOSCIENCES INC | COM | 45166A102 |  | 8510065 | 468358 | SH |  | SOLE |  | 468358 | 0 | 0 |
| IKENA ONCOLOGY INC | COM | 45175G108 |  | 325895 | 122517 | SH |  | SOLE |  | 122517 | 0 | 0 |
| INOGEN INC | COM | 45780L104 |  | 295650 | 15000 | SH |  | SOLE |  | 15000 | 0 | 0 |
| ISHARES NASDAQ BIOTECH INDX | ETF | 464287556 |  | 13457225 | 102500 | SH |  | SOLE |  | 102500 | 0 | 0 |
| ITEOS THERAPEUTICS INC | COM | 46565G104 |  | 1924877 | 98560 | SH |  | SOLE |  | 98560 | 0 | 0 |
| IVERIC BIO INC | COM | 46583P102 |  | 12973925 | 605975 | SH |  | SOLE |  | 605975 | 0 | 0 |
| KALVISTA PHARMACEUTICALS INC | COM | 483497103 |  | 4164376 | 616032 | SH |  | SOLE |  | 616032 | 0 | 0 |
| KARUNA THERAPEUTICS INC | COM | 48576A100 |  | 14153306 | 72027 | SH |  | SOLE |  | 72027 | 0 | 0 |
| KARYOPHARM THERAPEUTICS INC | COM | 48576U106 |  | 655105 | 192678 | SH |  | SOLE |  | 192678 | 0 | 0 |
| KEROS THERAPEUTICS INC | COM | 492327101 |  | 1584660 | 33000 | SH |  | SOLE |  | 33000 | 0 | 0 |
| KINNATE BIOPHARMA INC | COM | 49705R105 |  | 433149 | 71008 | SH |  | SOLE |  | 71008 | 0 | 0 |
| KURA ONCOLOGY INC | COM | 50127T109 |  | 1796769 | 144784 | SH |  | SOLE |  | 144784 | 0 | 0 |
| LARIMAR THERAPEUTICS INC | COM | 517125100 |  | 1954052 | 473136 | SH |  | SOLE |  | 473136 | 0 | 0 |
| LINEAGE CELL THERAPEUTICS IN | COM | 53566P109 |  | 163800 | 140000 | SH |  | SOLE |  | 140000 | 0 | 0 |
| MACROGENICS INC | COM | 556099109 |  | 267588 | 39879 | SH |  | SOLE |  | 39879 | 0 | 0 |
| MASIMO CORP | COM | 574795100 |  | 443850 | 3000 | SH |  | SOLE |  | 3000 | 0 | 0 |
| MEDICENNA THERAPEUTICS CORP | COM | 58490H107 |  | 302280 | 660000 | SH |  | SOLE |  | 660000 | 0 | 0 |
| MEDIWOUND LTD | SHS NEW | M68830112 |  | 2753066 | 204082 | SH |  | SOLE |  | 204082 | 0 | 0 |
| MEREO BIOPHARMA GROUP PLC | SPON ADS | 589492107 |  | 822385 | 1096513 | SH |  | SOLE |  | 1096513 | 0 | 0 |
| MERSANA THERAPEUTICS INC | COM | 59045L106 |  | 2422893 | 413463 | SH |  | SOLE |  | 413463 | 0 | 0 |
| MERUS N V | COM | N5749R100 |  | 4175245 | 269893 | SH |  | SOLE |  | 269893 | 0 | 0 |
| MIRATI THERAPEUTICS INC | COM | 60468T105 |  | 3334816 | 73600 | SH |  | SOLE |  | 73600 | 0 | 0 |
| MORPHIC HOLDING INC | COM | 61775R105 |  | 5228742 | 195467 | SH |  | SOLE |  | 195467 | 0 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 |  | 8733572 | 73121 | SH |  | SOLE |  | 73121 | 0 | 0 |
| NEURONETICS INC | COM | 64131A105 |  | 2155236 | 313717 | SH |  | SOLE |  | 313717 | 0 | 0 |
| NEXTCURE INC | COM | 65343E108 |  | 264651 | 187696 | SH |  | SOLE |  | 187696 | 0 | 0 |
| NURIX THERAPEUTICS INC | COM | 67080M103 |  | 6222311 | 566695 | SH |  | SOLE |  | 566695 | 0 | 0 |
| ORIC PHARMACEUTICALS INC | COM | 68622P109 |  | 1556356 | 264237 | SH |  | SOLE |  | 264237 | 0 | 0 |
| PARDES BIOSCIENCES INC | COM | 69945Q105 |  | 810162 | 479386 | SH |  | SOLE |  | 479386 | 0 | 0 |
| PHASEBIO PHARMACEUTICALS INC | COM | 717224109 |  | 9688 | 321856 | SH |  | SOLE |  | 321856 | 0 | 0 |
| REGULUS THERAPEUTICS INC | COM | 75915K309 |  | 761110 | 555555 | SH |  | SOLE |  | 555555 | 0 | 0 |
| REUNION NEUROSCIENCE INC | COM | 76134G103 |  | 42911 | 47679 | SH |  | SOLE |  | 47679 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 11380839 | 477785 | SH |  | SOLE |  | 477785 | 0 | 0 |
| SAGE THERAPEUTICS INC | COM | 78667J108 |  | 6876871 | 180306 | SH |  | SOLE |  | 180306 | 0 | 0 |
| SCYNEXIS INC | COM NEW | 811292200 |  | 239100 | 153269 | SH |  | SOLE |  | 153269 | 0 | 0 |
| SPDR S BIOTECH ETF | ETF | 78464A870 |  | 46978000 | 566000 | SH |  | SOLE |  | 566000 | 0 | 0 |
| SPERO THERAPEUTICS INC | COM | 84833T103 |  | 216250 | 125000 | SH |  | SOLE |  | 125000 | 0 | 0 |
| STEREOTAXIS INC | COM NEW | 85916J409 |  | 28318747 | 13680554 | SH |  | SOLE |  | 13680554 | 0 | 0 |
| SURFACE ONCOLOGY INC | COM | 86877M209 |  | 642060 | 783000 | SH |  | SOLE |  | 783000 | 0 | 0 |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 |  | 11378008 | 447073 | SH |  | SOLE |  | 447073 | 0 | 0 |
| SYROS PHARMACEUTICALS INC | COM NEW | 87184Q206 |  | 954502 | 265878 | SH |  | SOLE |  | 265878 | 0 | 0 |
| THESEUS PHARMACEUTICALS INC | COM | 88369M101 |  | 407658 | 81859 | SH |  | SOLE |  | 81859 | 0 | 0 |
| VIGIL NEUROSCIENCE INC | COM | 92673K108 |  | 2110575 | 168846 | SH |  | SOLE |  | 168846 | 0 | 0 |
| VIKING THERAPEUTICS INC | COM | 92686J106 |  | 4902598 | 521553 | SH |  | SOLE |  | 521553 | 0 | 0 |
| XENON PHARMACEUTICALS INC | COM | 98420N105 |  | 12463508 | 316092 | SH |  | SOLE |  | 316092 | 0 | 0 |

---