# EDGAR Filing Document

**Accession Number:** 0001129928
**File Stem:** 0001104659-25-084052
**Filing Date:** 2025-8
**Character Count:** 2193
**Document Hash:** 3be2e373e878b000a55fde99cd18f047
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-25-084052.hdr.sgml**: 20250929

**ACCESSION NUMBER**: 0001104659-25-084052

**CONFORMED SUBMISSION TYPE**: CORRESP

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20250827

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** ONCOLYTICS BIOTECH INC
- **CENTRAL INDEX KEY:** 0001129928
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** CORRESP

**BUSINESS ADDRESS:**
- **STREET 1:** 804, 322 - 11 AVENUE SW
- **CITY:** CALGARY
- **STATE:** A0
- **ZIP:** T2R 0C5
- **BUSINESS PHONE:** 4036707380

**MAIL ADDRESS:**
- **STREET 1:** 804, 322 - 11 AVENUE SW
- **CITY:** CALGARY
- **STATE:** A0
- **ZIP:** T2R 0C5

**ONCOLYTICS BIOTECH INC.**

**Suite 804, 322 11th Avenue SW**

**Calgary, Alberta, Canada, T2R 0C5**

**<u>VIA EDGAR</u>**

August 27, 2025

United States Securities and Exchange Commission

Division of Corporation Finance

Office of Life Sciences

100 F Street, N.E.

Washington, D.C. 20549

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| | |
|:---|:---|
| Attention: | Tyler Howes |
| Re: | Oncolytics Biotech Inc. |
|  | Registration Statement on Form F-3 |
|  | File No. 333-289819 |

---

To the addressee set forth above:

Pursuant to Rule 461 of the U.S. Securities Act of 1933, as amended, Oncolytics Biotech Inc. (the "Company") hereby requests acceleration of the effective date of its registration statement on Form F-3 (File No. 333-289819) (the "Registration Statement"), to 4:00 p.m. Eastern Time on August 29, 2025, or as soon thereafter as practicable.

Please contact Christopher J. Clark of Latham & Watkins LLP, special U.S. counsel to the Company, at (202) 637-2374 or Christopher.J.Clark@lw.com, as soon as the Registration Statement has been declared effective, or if you have any other questions or concerns regarding this matter.

---

| | |
|:---|:---|
| Very truly yours, | Very truly yours, |
| ONCOLYTICS BIOTECH INC. | ONCOLYTICS BIOTECH INC. |
| By: | /s/ Kirk Look |
| Name: | Kirk Look |
| Title: | Chief Financial Officer |

---

cc: Christopher J. Clark, Esq., Latham & Watkins LLP