# EDGAR Filing Document

**Accession Number:** 0001802630
**File Stem:** 0001802630-26-000003
**Filing Date:** 2026-5
**Character Count:** 13151
**Document Hash:** bfa2bbdac3b7321072b8e5edad0201d8
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001802630-26-000003.hdr.sgml**: 20260514

**ACCESSION NUMBER**: 0001802630-26-000003

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20260331

**FILED AS OF DATE**: 20260514

**DATE AS OF CHANGE**: 20260514

**EFFECTIVENESS DATE**: 20260514

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Soleus Capital Management, L.P.
- **CENTRAL INDEX KEY:** 0001802630

**ORGANIZATION NAME:**
- **EIN:** 384052641
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-20043
- **FILM NUMBER:** 26976889

**BUSINESS ADDRESS:**
- **STREET 1:** 100 FIELD POINT ROAD
- **STREET 2:** SUITE 200
- **CITY:** GREENWICH
- **STATE:** CT
- **ZIP:** 06830
- **BUSINESS PHONE:** 203-542-5527

**MAIL ADDRESS:**
- **STREET 1:** 100 FIELD POINT ROAD
- **STREET 2:** SUITE 200
- **CITY:** GREENWICH
- **STATE:** CT
- **ZIP:** 06830

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 03-31-2026

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** Soleus Capital Management L.P.<br>**Address:** 100 FIELD POINT ROAD<br>SUITE 200<br>GREENWICH, CT 06830

**Form 13F File Number:** 028-20043

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Harold Schaaff<br>**Title:** Chief Compliance Officer Soleus Capital Management L.P.<br>**Phone:** 475-284-2761

**Signature, Place, and Date of Signing:**

Harold Schaaff  Greenwich, CT  05-14-2026<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 93

**Form 13F Information Table Value Total:** $2469218478

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| ALKERMES PLC | SHS | G01767105 |  | 69689751 | 1970864 | SH |  | SOLE |  | 1970864 | 0 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 |  | 43559036 | 131650 | SH |  | SOLE |  | 131650 | 0 | 0 |
| ANAPTYSBIO INC | COM | 032724106 |  | 332760 | 6000 | SH |  | SOLE |  | 6000 | 0 | 0 |
| ANI PHARMACEUTICALS INC | COM | 00182C103 |  | 63076687 | 820243 | SH |  | SOLE |  | 820243 | 0 | 0 |
| ARCUS BIOSCIENCES INC | COM | 03969F109 |  | 9762833 | 451983 | SH |  | SOLE |  | 451983 | 0 | 0 |
| ARGENX SE | SPONSORED ADR | 04016X101 |  | 2555875 | 3500 | SH |  | SOLE |  | 3500 | 0 | 0 |
| ARROWHEAD PHARMACEUTICALS IN | COM | 04280A100 |  | 1785633 | 28479 | SH |  | SOLE |  | 28479 | 0 | 0 |
| AVALO THERAPEUTICS INC | COM NEW | 05338F306 |  | 6598732 | 441978 | SH |  | SOLE |  | 441978 | 0 | 0 |
| AXOGEN INC | COM | 05463X106 |  | 22500902 | 679170 | SH |  | SOLE |  | 679170 | 0 | 0 |
| BETA BIONICS INC | COM | 08659B102 |  | 43632100 | 4354501 | SH |  | SOLE |  | 4354501 | 0 | 0 |
| BIODESIX INC | COM | 09075X207 |  | 6040686 | 416599 | SH |  | SOLE |  | 416599 | 0 | 0 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 |  | 36750812 | 650572 | SH |  | SOLE |  | 650572 | 0 | 0 |
| C4 THERAPEUTICS INC | COM STK | 12529R107 |  | 10004367 | 3803942 | SH |  | SOLE |  | 3803942 | 0 | 0 |
| CELCUITY INC | COM | 15102K100 |  | 146598905 | 1284378 | SH |  | SOLE |  | 1284378 | 0 | 0 |
| CERUS CORP | COM | 157085101 |  | 19571734 | 10753700 | SH |  | SOLE |  | 10753700 | 0 | 0 |
| CG ONCOLOGY INC | COM | 156944100 |  | 1353600 | 20000 | SH |  | SOLE |  | 20000 | 0 | 0 |
| COGENT BIOSCIENCES INC | COM | 19240Q201 |  | 384900 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| CONTEXT THERAPEUTICS INC | COM | 21077P108 |  | 18243429 | 6963141 | SH |  | SOLE |  | 6963141 | 0 | 0 |
| CORCEPT THERAPEUTICS INC | COM | 218352102 |  | 11509755 | 285531 | SH |  | SOLE |  | 285531 | 0 | 0 |
| CULLINAN THERAPEUTICS INC | COM | 230031106 |  | 5828942 | 410200 | SH |  | SOLE |  | 410200 | 0 | 0 |
| CYTOMX THERAPEUTICS INC. | COM | 23284F105 |  | 1410000 | 300000 | SH |  | SOLE |  | 300000 | 0 | 0 |
| DEXCOM INC | COM | 252131107 |  | 8792000 | 140000 | SH |  | SOLE |  | 140000 | 0 | 0 |
| EDAP TMS S A | SPONSORED ADR | 268311107 |  | 27190425 | 7309254 | SH |  | SOLE |  | 7309254 | 0 | 0 |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 |  | 45672323 | 1449915 | SH |  | SOLE |  | 1449915 | 0 | 0 |
| ENLIVEN THERAPEUTICS INC | COM | 29337E102 |  | 9050065 | 230869 | SH |  | SOLE |  | 230869 | 0 | 0 |
| ETON PHARMACEUTICALS INC | COM | 29772L108 |  | 4106283 | 166381 | SH |  | SOLE |  | 166381 | 0 | 0 |
| EVOLUS INC | COM | 30052C107 |  | 9228430 | 2245360 | SH |  | SOLE |  | 2245360 | 0 | 0 |
| GERON CORP | COM | 374163103 |  | 61847902 | 41508659 | SH |  | SOLE |  | 41508659 | 0 | 0 |
| GLOBUS MED INC | CL A | 379577208 |  | 62850877 | 729467 | SH |  | SOLE |  | 729467 | 0 | 0 |
| ICON PLC | SHS | G4705A100 |  | 21246720 | 192000 | SH |  | SOLE |  | 192000 | 0 | 0 |
| IMMUNIC INC | COM | 4525EP101 |  | 4995000 | 4500000 | SH |  | SOLE |  | 4500000 | 0 | 0 |
| IMMUNOVANT INC | COM | 45258J102 |  | 5713200 | 230000 | SH |  | SOLE |  | 230000 | 0 | 0 |
| INDIVIOR PHARMACEUTICALS INC | COM | 45579U109 |  | 38831520 | 1274000 | SH |  | SOLE |  | 1274000 | 0 | 0 |
| INHIBIKASE THERAPEUTICS INC | COM NEW | 45719W205 |  | 18270000 | 10875000 | SH |  | SOLE |  | 10875000 | 0 | 0 |
| INHIBRX BIOSCIENCES INC | COM | 45720N103 |  | 8807130 | 131000 | SH |  | SOLE |  | 131000 | 0 | 0 |
| INSMED INC | COM PAR $.01 | 457669307 |  | 1676080 | 10250 | SH |  | SOLE |  | 10250 | 0 | 0 |
| INSPIRE MED SYS INC | COM | 457730109 |  | 29725502 | 576299 | SH |  | SOLE |  | 576299 | 0 | 0 |
| INSPIREMD INC | COM | 45779A846 |  | 1704504 | 1045708 | SH |  | SOLE |  | 1045708 | 0 | 0 |
| INSULET CORP | COM | 45784P101 |  | 118035000 | 562500 | SH |  | SOLE |  | 562500 | 0 | 0 |
| INVIVYD INC | COM | 00534A102 |  | 10021345 | 7708727 | SH |  | SOLE |  | 7708727 | 0 | 0 |
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 |  | 3510000 | 1000000 | SH |  | SOLE |  | 1000000 | 0 | 0 |
| JADE BIOSCIENCES INC | COM NEW | 008064206 |  | 11194253 | 796744 | SH |  | SOLE |  | 796744 | 0 | 0 |
| JASPER THERAPEUTICS INC | COM NEW | 471871202 |  | 242105 | 276312 | SH |  | SOLE |  | 276312 | 0 | 0 |
| KARYOPHARM THERAPEUTICS INC | COM NEW | 48576U205 |  | 2450800 | 440000 | SH |  | SOLE |  | 440000 | 0 | 0 |
| KINIKSA PHARMACEUTICALS INTL | ORD SHS CL A | G52694109 |  | 25103147 | 521353 | SH |  | SOLE |  | 521353 | 0 | 0 |
| KRYSTAL BIOTECH INC | COM | 501147102 |  | 297865434 | 1153087 | SH |  | SOLE |  | 1153087 | 0 | 0 |
| LARIMAR THERAPEUTICS INC | COM | 517125100 |  | 4801320 | 1066960 | SH |  | SOLE |  | 1066960 | 0 | 0 |
| LB PHARMACEUTICALS INC | COM SHS | 50180M108 |  | 246600 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| LIVANOVA PLC | SHS | G5509L101 |  | 37023700 | 582500 | SH |  | SOLE |  | 582500 | 0 | 0 |
| MBX BIOSCIENCES INC | COM | 55287L101 |  | 5340075 | 178897 | SH |  | SOLE |  | 178897 | 0 | 0 |
| MERCK  CO INC | COM | 58933Y105 |  | 24418870 | 203000 | SH |  | SOLE |  | 203000 | 0 | 0 |
| MIRUM PHARMACEUTICALS INC | COM | 604749101 |  | 36980268 | 400306 | SH |  | SOLE |  | 400306 | 0 | 0 |
| NATERA INC | COM | 632307104 |  | 23798810 | 119000 | SH |  | SOLE |  | 119000 | 0 | 0 |
| NEOGENOMICS INC | COM NEW | 64049M209 |  | 1298500 | 175000 | SH |  | SOLE |  | 175000 | 0 | 0 |
| NEUROPACE INC | COM | 641288105 |  | 38558522 | 2932207 | SH |  | SOLE |  | 2932207 | 0 | 0 |
| NOVOCURE LTD | ORD SHS | G6674U108 |  | 114367062 | 10492391 | SH |  | SOLE |  | 10492391 | 0 | 0 |
| NURIX THERAPEUTICS INC | COM | 67080M103 |  | 14541527 | 938163 | SH |  | SOLE |  | 938163 | 0 | 0 |
| ORGANOGENESIS HLDGS INC | COM | 68621F102 |  | 23903704 | 10085951 | SH |  | SOLE |  | 10085951 | 0 | 0 |
| ORTHOPEDIATRICS CORP | COM | 68752L100 |  | 9767144 | 615447 | SH |  | SOLE |  | 615447 | 0 | 0 |
| ORUKA THERAPEUTICS INC | COM | 687604108 |  | 245250 | 5000 | SH |  | SOLE |  | 5000 | 0 | 0 |
| PHARVARIS N V | COM | N69605108 |  | 19832969 | 702052 | SH |  | SOLE |  | 702052 | 0 | 0 |
| PRAXIS PRECISION MEDICINES I | COM NEW | 74006W207 |  | 106489272 | 330517 | SH |  | SOLE |  | 330517 | 0 | 0 |
| PROCEPT BIOROBOTICS CORP | COM | 74276L105 |  | 4001600 | 160000 | SH |  | SOLE |  | 160000 | 0 | 0 |
| PROGYNY INC | COM | 74340E103 |  | 35097660 | 2067000 | SH |  | SOLE |  | 2067000 | 0 | 0 |
| PULMONX CORP | COM | 745848101 |  | 3596937 | 2788323 | SH |  | SOLE |  | 2788323 | 0 | 0 |
| QUOIN PHARMACEUTICALS LTD | SPONSORED ADS | 74907L409 |  | 480018 | 72730 | SH |  | SOLE |  | 72730 | 0 | 0 |
| RAPPORT THERAPEUTICS INC | COM | 75383L102 |  | 312900 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| RELMADA THERAPEUTICS INC | COM | 75955J402 |  | 5861058 | 842106 | SH |  | SOLE |  | 842106 | 0 | 0 |
| RIGEL PHARMACEUTICALS INC | COM | 766559702 |  | 270400 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| SAB BIOTHERAPEUTICS INC | COM NEW | 78397T202 |  | 4021500 | 1050000 | SH |  | SOLE |  | 1050000 | 0 | 0 |
| SATELLOS BIOSCIENCE INC | COM | 80401L803 |  | 2332841 | 414359 | SH |  | SOLE |  | 414359 | 0 | 0 |
| SEPTERNA INC | COM | 81734D104 |  | 6608250 | 275000 | SH |  | SOLE |  | 275000 | 0 | 0 |
| SIONNA THERAPEUTICS INC | COM | 829401108 |  | 11766415 | 293500 | SH |  | SOLE |  | 293500 | 0 | 0 |
| SOPHIA GENETICS SA | ORDINARY SHARES | H82027105 |  | 9157500 | 1850000 | SH |  | SOLE |  | 1850000 | 0 | 0 |
| STAAR SURGICAL CO | COM PAR $0.01 | 852312305 |  | 374000 | 20000 | SH |  | SOLE |  | 20000 | 0 | 0 |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 |  | 3856000 | 80000 | SH |  | SOLE |  | 80000 | 0 | 0 |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 |  | 40340571 | 1726908 | SH |  | SOLE |  | 1726908 | 0 | 0 |
| TANDEM DIABETES CARE INC | COM NEW | 875372203 |  | 15010110 | 783000 | SH |  | SOLE |  | 783000 | 0 | 0 |
| TANGO THERAPEUTICS INC | COM | 87583X109 |  | 9414000 | 450000 | SH |  | SOLE |  | 450000 | 0 | 0 |
| TECTONIC THERAPEUTIC INC | COM | 878972108 |  | 3761252 | 121684 | SH |  | SOLE |  | 121684 | 0 | 0 |
| TG THERAPEUTICS INC | COM | 88322Q108 |  | 133853977 | 4029319 | SH |  | SOLE |  | 4029319 | 0 | 0 |
| TRAVERE THERAPEUTICS INC | COM | 89422G107 |  | 16221660 | 546000 | SH |  | SOLE |  | 546000 | 0 | 0 |
| TREVI THERAPEUTICS INC | COM | 89532M101 |  | 19326600 | 1620000 | SH |  | SOLE |  | 1620000 | 0 | 0 |
| TWIST BIOSCIENCE CORP | COM | 90184D100 |  | 58289410 | 1226629 | SH |  | SOLE |  | 1226629 | 0 | 0 |
| TYRA BIOSCIENCES INC | COM | 90240B106 |  | 383000 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| UNITED THERAPEUTICS CORP DEL | COM | 91307C102 |  | 110998147 | 187187 | SH |  | SOLE |  | 187187 | 0 | 0 |
| UROGEN PHARMA LTD | COM | M96088105 |  | 13071460 | 727000 | SH |  | SOLE |  | 727000 | 0 | 0 |
| VAXCYTE INC | COM | 92243G108 |  | 22399778 | 385472 | SH |  | SOLE |  | 385472 | 0 | 0 |
| VERACYTE INC | COM | 92337F107 |  | 10304366 | 319912 | SH |  | SOLE |  | 319912 | 0 | 0 |
| VERICEL CORP | COM | 92346J108 |  | 82003871 | 2549079 | SH |  | SOLE |  | 2549079 | 0 | 0 |
| VIR BIOTECHNOLOGY INC | COM | 92764N102 |  | 17937920 | 2002000 | SH |  | SOLE |  | 2002000 | 0 | 0 |
| XENON PHARMACEUTICALS INC | COM | 98420N105 |  | 16979800 | 292000 | SH |  | SOLE |  | 292000 | 0 | 0 |
| ZYMEWORKS INC | COM | 98985Y108 |  | 250400 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |

---