# EDGAR Filing Document

**Accession Number:** 0001785173
**File Stem:** 0000902664-25-004297
**Filing Date:** 2025-10
**Character Count:** 23799
**Document Hash:** c5093b7f617af69771054442b9bce662
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000902664-25-004297.hdr.sgml**: 20251003

**ACCESSION NUMBER**: 0000902664-25-004297

**CONFORMED SUBMISSION TYPE**: SCHEDULE 13D

**PUBLIC DOCUMENT COUNT**: 4

**FILED AS OF DATE**: 20251003

**DATE AS OF CHANGE**: 20251003

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** 89bio, Inc.
- **CENTRAL INDEX KEY:** 0001785173
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 831114349
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SCHEDULE 13D
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-91200
- **FILM NUMBER:** 251373639

**BUSINESS ADDRESS:**
- **STREET 1:** 655 MONTGOMERY STREET
- **STREET 2:** SUITE 1500
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94111
- **BUSINESS PHONE:** (415) 432-9270

**MAIL ADDRESS:**
- **STREET 1:** 655 MONTGOMERY STREET
- **STREET 2:** SUITE 1500
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94111
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Adage Capital Management, L.P.
- **CENTRAL INDEX KEY:** 0001535978

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SCHEDULE 13D

**BUSINESS ADDRESS:**
- **STREET 1:** 200 CLARENDON STREET, 52ND FLOOR
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02116
- **BUSINESS PHONE:** 617-867-2800

**MAIL ADDRESS:**
- **STREET 1:** 200 CLARENDON STREET, 52ND FLOOR
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02116

## Ex-99

**<u>SCHEDULE A</u>**

GENERAL PARTNERS, CONTROL PERSONS, DIRECTORS AND EXECUTIVE OFFICERS OF CERTAIN REPORTING PERSONS

The following sets forth the name, position, address, principal occupation and citizenship of each general partner, control person, director and/or executive officer of the applicable Reporting Persons (the "<u>Instruction C Persons</u>"). To the best of the Reporting Persons' knowledge, (i) none of the Instruction C Persons during the last five years has been convicted in a criminal proceeding (excluding traffic violations or other similar misdemeanors) or been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws and (ii) none of the Instruction C Persons owns any shares of Common Stock or is party to any contract or agreement as would require disclosure in this Schedule 13D, except to the extent such Instruction C Person is a Reporting Person in which case such Instruction C Person's beneficial ownership is as set forth in Item 5 of the Schedule 13D.

**REPORTING PERSON: ADAGE CAPITAL MANAGEMENT, L.P. (**"**<u>ACM</u>**"**)**

Adage Capital Partners L.L.C. ("<u>ACPLLC</u>") serves as the general partner of ACM. Its business address is c/o Adage Capital Management, L.P., 200 Clarendon Street, 52nd Floor, Boston, Massachusetts 02116. Its principal occupation is serving as the general partner of ACM. ACPLLC is a Delaware limited liability company.

Adage Capital Advisors, L.L.C. ("<u>ACA</u>"), serves as the managing member of ACPLLC. The business address of ACA is c/o Adage Capital Management, L.P., 200 Clarendon Street, 52nd Floor, Boston, Massachusetts 02116. The principal occupation of ACA is serving as managing member of ACPLLC. ACA is a Delaware limited liability company.

Messrs. Atchinson and Gross serve as the managing members of ACA. Messrs. Atchinson and Gross are Reporting Persons.

## Ex-99

**<u>Schedule B</u>**

This Schedule sets forth information with respect to each purchase and sale of shares of Common Stock which were effectuated by the Reporting Persons within the past sixty (60) days. All transactions were effectuated in the open market through a broker. The price reported in the column Price Per Share ($) is a weighted average price if a price range is indicated in the column Price Range ($). These shares of Common Stock were purchased or sold in multiple transactions at prices between the price ranges below. The Reporting Persons will undertake to provide to the staff of the SEC, upon request, full information regarding the number of shares of Common Stock purchased or sold at each separate price.

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;<u>Trade Date</u> | &nbsp;&nbsp;<u>Trade Date</u> | &nbsp;&nbsp;<u>Shares Purchased (Sold)</u> | &nbsp;&nbsp;<u>Price Per Share ($)\*</u> | &nbsp;&nbsp;<u>Price Per Share ($)\*</u> | &nbsp;&nbsp;<u>Price Range ($)\*</u> |
| &nbsp;&nbsp;9/3/2025 | &nbsp;&nbsp;(74659) | &nbsp;&nbsp;(74659) | &nbsp;&nbsp;(74659) | &nbsp;&nbsp;9.2500 |  |
| &nbsp;&nbsp;9/4/2025 | &nbsp;&nbsp;(77754) | &nbsp;&nbsp;(77754) | &nbsp;&nbsp;(77754) | &nbsp;&nbsp;9.3001 | &nbsp;&nbsp;9.2500-9.4700 |
| &nbsp;&nbsp;9/9/2025 | &nbsp;&nbsp;632 | &nbsp;&nbsp;632 | &nbsp;&nbsp;632 | &nbsp;&nbsp;8.5000 |  |
| &nbsp;&nbsp;9/9/2025 | &nbsp;&nbsp;1566 | &nbsp;&nbsp;1566 | &nbsp;&nbsp;1566 | &nbsp;&nbsp;8.4923 | &nbsp;&nbsp;8.4800-8.5000 |
| &nbsp;&nbsp;9/9/2025 | &nbsp;&nbsp;1500 | &nbsp;&nbsp;1500 | &nbsp;&nbsp;1500 | &nbsp;&nbsp;8.5000 |  |
| &nbsp;&nbsp;9/9/2025 | &nbsp;&nbsp;300 | &nbsp;&nbsp;300 | &nbsp;&nbsp;300 | &nbsp;&nbsp;8.4983 | &nbsp;&nbsp;8.4950-8.5000 |
| &nbsp;&nbsp;9/9/2025 | &nbsp;&nbsp;250 | &nbsp;&nbsp;250 | &nbsp;&nbsp;250 | &nbsp;&nbsp;8.4800 |  |
| &nbsp;&nbsp;9/9/2025 | &nbsp;&nbsp;566 | &nbsp;&nbsp;566 | &nbsp;&nbsp;566 | &nbsp;&nbsp;8.4984 | &nbsp;&nbsp;8.4950-8.5000 |
| &nbsp;&nbsp;9/9/2025 | &nbsp;&nbsp;342 | &nbsp;&nbsp;342 | &nbsp;&nbsp;342 | &nbsp;&nbsp;8.4967 | &nbsp;&nbsp;8.4800-8.5000 |
| &nbsp;&nbsp;9/9/2025 | &nbsp;&nbsp;500 | &nbsp;&nbsp;500 | &nbsp;&nbsp;500 | &nbsp;&nbsp;8.5000 |  |
| &nbsp;&nbsp;9/9/2025 | &nbsp;&nbsp;540 | &nbsp;&nbsp;540 | &nbsp;&nbsp;540 | &nbsp;&nbsp;8.4950 |  |
| &nbsp;&nbsp;9/10/2025 | &nbsp;&nbsp;666 | &nbsp;&nbsp;666 | &nbsp;&nbsp;666 | &nbsp;&nbsp;8.6465 | &nbsp;&nbsp;8.6300-8.6500 |
| &nbsp;&nbsp;9/10/2025 | &nbsp;&nbsp;400 | &nbsp;&nbsp;400 | &nbsp;&nbsp;400 | &nbsp;&nbsp;8.6450 | &nbsp;&nbsp;8.6400-8.6500 |
| &nbsp;&nbsp;9/10/2025 | &nbsp;&nbsp;13107 | &nbsp;&nbsp;13107 | &nbsp;&nbsp;13107 | &nbsp;&nbsp;8.6428 | &nbsp;&nbsp;8.6100-8.6500 |
| &nbsp;&nbsp;9/10/2025 | &nbsp;&nbsp;1000 | &nbsp;&nbsp;1000 | &nbsp;&nbsp;1000 | &nbsp;&nbsp;8.6400 |  |
| &nbsp;&nbsp;9/10/2025 | &nbsp;&nbsp;867 | &nbsp;&nbsp;867 | &nbsp;&nbsp;867 | &nbsp;&nbsp;8.6355 | &nbsp;&nbsp;8.5700-8.6500 |
| &nbsp;&nbsp;9/10/2025 | &nbsp;&nbsp;3550 | &nbsp;&nbsp;3550 | &nbsp;&nbsp;3550 | &nbsp;&nbsp;8.6463 | &nbsp;&nbsp;8.6300-8.6500 |
| &nbsp;&nbsp;9/10/2025 | &nbsp;&nbsp;12672 | &nbsp;&nbsp;12672 | &nbsp;&nbsp;12672 | &nbsp;&nbsp;8.6400 | &nbsp;&nbsp;8.5800-8.6500 |
| &nbsp;&nbsp;9/10/2025 | &nbsp;&nbsp;5564 | &nbsp;&nbsp;5564 | &nbsp;&nbsp;5564 | &nbsp;&nbsp;8.6410 | &nbsp;&nbsp;8.6000-8.6500 |
| &nbsp;&nbsp;9/10/2025 | &nbsp;&nbsp;100 | &nbsp;&nbsp;100 | &nbsp;&nbsp;100 | &nbsp;&nbsp;8.6300 |  |
| &nbsp;&nbsp;9/10/2025 | &nbsp;&nbsp;5678 | &nbsp;&nbsp;5678 | &nbsp;&nbsp;5678 | &nbsp;&nbsp;8.6424 | &nbsp;&nbsp;8.6100-8.6500 |
| &nbsp;&nbsp;9/10/2025 | &nbsp;&nbsp;200 | &nbsp;&nbsp;200 | &nbsp;&nbsp;200 | &nbsp;&nbsp;8.6500 |  |
| &nbsp;&nbsp;9/18/2025 | &nbsp;&nbsp;550000 | &nbsp;&nbsp;550000 | &nbsp;&nbsp;550000 | &nbsp;&nbsp;14.9849 | &nbsp;&nbsp;14.9650-15.0000 |
| &nbsp;&nbsp;9/18/2025 | &nbsp;&nbsp;300000 | &nbsp;&nbsp;300000 | &nbsp;&nbsp;300000 | &nbsp;&nbsp;14.9850 |  |
| &nbsp;&nbsp;9/18/2025 | &nbsp;&nbsp;100000 | &nbsp;&nbsp;100000 | &nbsp;&nbsp;100000 | &nbsp;&nbsp;14.9750 |  |
| &nbsp;&nbsp;9/18/2025 | &nbsp;&nbsp;100000 | &nbsp;&nbsp;100000 | &nbsp;&nbsp;100000 | &nbsp;&nbsp;14.9850 |  |
| &nbsp;&nbsp;9/18/2025 | &nbsp;&nbsp;406357 | &nbsp;&nbsp;406357 | &nbsp;&nbsp;406357 | &nbsp;&nbsp;14.9810 | &nbsp;&nbsp;14.9550-15.0000 |
| &nbsp;&nbsp;9/18/2025 | &nbsp;&nbsp;500000 | &nbsp;&nbsp;500000 | &nbsp;&nbsp;500000 | &nbsp;&nbsp;14.9679 | &nbsp;&nbsp;14.9400-14.9900 |
| &nbsp;&nbsp;9/18/2025 | &nbsp;&nbsp;693643 | &nbsp;&nbsp;693643 | &nbsp;&nbsp;693643 | &nbsp;&nbsp;14.8978 | &nbsp;&nbsp;14.8200-15.0000 |
| &nbsp;&nbsp;9/19/2025 | &nbsp;&nbsp;900000 | &nbsp;&nbsp;900000 | &nbsp;&nbsp;900000 | &nbsp;&nbsp;14.9300 | &nbsp;&nbsp;14.8900-14.9550 |
| &nbsp;&nbsp;9/22/2025 | &nbsp;&nbsp;1059800 | &nbsp;&nbsp;1059800 | &nbsp;&nbsp;1059800 | &nbsp;&nbsp;14.8728 | &nbsp;&nbsp;14.8700-14.9000 |
| &nbsp;&nbsp;9/22/2025 | &nbsp;&nbsp;40200 | &nbsp;&nbsp;40200 | &nbsp;&nbsp;40200 | &nbsp;&nbsp;14.8890 | &nbsp;&nbsp;14.8850-14.8950 |
| &nbsp;&nbsp;9/22/2025 | &nbsp;&nbsp;250000 | &nbsp;&nbsp;250000 | &nbsp;&nbsp;250000 | &nbsp;&nbsp;14.8880 | &nbsp;&nbsp;14.8650-14.9000 |
| &nbsp;&nbsp;9/23/2025 | &nbsp;&nbsp;250000 | &nbsp;&nbsp;250000 | &nbsp;&nbsp;250000 | &nbsp;&nbsp;14.8282 | &nbsp;&nbsp;14.8250-14.8300 |
| &nbsp;&nbsp;9/26/2025 | &nbsp;&nbsp;250000 | &nbsp;&nbsp;250000 | &nbsp;&nbsp;250000 | &nbsp;&nbsp;14.7050 |  |
| &nbsp;&nbsp;9/26/2025 | &nbsp;&nbsp;1250000 | &nbsp;&nbsp;1250000 | &nbsp;&nbsp;1250000 | &nbsp;&nbsp;14.7063 | &nbsp;&nbsp;14.6950-14.7150 |
| &nbsp;&nbsp;9/29/2025 | &nbsp;&nbsp;250000 | &nbsp;&nbsp;250000 | &nbsp;&nbsp;250000 | &nbsp;&nbsp;14.7058 | &nbsp;&nbsp;14.6950-14.7100 |

---

\* Excluding commissions.

## Exhibit 99.1

**EXHIBIT 99.1**

**JOINT FILING AGREEMENT<br> PURSUANT TO RULE 13d-1(k)**

The undersigned acknowledge and agree that the foregoing statement on Schedule 13D is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on Schedule 13D shall be filed on behalf of each of the undersigned without the necessity of filing additional joint filing agreements. The undersigned acknowledge that each shall be responsible for the timely filing of such amendments, and for the completeness and accuracy of the information concerning him or it contained herein and therein, but shall not be responsible for the completeness and accuracy of the information concerning the others, except to the extent that he or it knows or has reason to believe that such information is inaccurate.

DATE: October 3, 2025

---

| |
|:---|
| ADAGE CAPITAL MANAGEMENT, L.P. |
| By: Adage Capital Partners LLC, |
| its general partner |
| <u>/s/ Robert Atchinson</u> |
| Name: Robert Atchinson |
| Title: Managing Member |
| <u>/s/ Robert Atchinson</u> |
| ROBERT ATCHINSON, individually |
| <u>/s/ Phillip Gross</u> |
| PHILLIP GROSS, individually |

---

### UNITED STATES SECURITIES AND EXCHANGE COMMISSION
**Washington, D.C. 20549**

## SCHEDULE 13D

### Under the Securities Exchange Act of 1934

**89bio, Inc.**

*(Name of Issuer)*

**Common Stock, par value $0.001 per share**

*(Title of Class of Securities)*

**282559103**

*(CUSIP Number)*

**Robert Atchinson**<br>Adage Capital Partners GP, L.L.C.<br>200 Clarendon Street, 52nd Floor<br>Boston MA 02116<br>617-867-2800

*(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)*

**09/26/2025**

*(Date of Event Which Requires Filing of this Statement)*

| **CUSIP No.** | **282559103** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**Adage Capital Management, L.P.** | Name of reporting person<br>**Adage Capital Management, L.P.** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**DELAWARE** | Citizenship or place of organization<br>**DELAWARE** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**9097587.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**9097587.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**9097587.00** | Aggregate amount beneficially owned by each reporting person<br>**9097587.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**6.13%** | Percent of class represented by amount in Row (11)<br>**6.13%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**IA** | Type of Reporting Person (See Instructions)<br>**IA** | |

---

| **CUSIP No.** | **282559103** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**Robert Atchinson** | Name of reporting person<br>**Robert Atchinson** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**X1** | Citizenship or place of organization<br>**X1** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**9097587.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**9097587.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**9097587.00** | Aggregate amount beneficially owned by each reporting person<br>**9097587.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**6.13%** | Percent of class represented by amount in Row (11)<br>**6.13%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**IN** | Type of Reporting Person (See Instructions)<br>**IN** | |

---

| **CUSIP No.** | **282559103** |

---

| | | | |
|:--|:--|:--|:--|
| 1 | Name of reporting person<br>**Phillip Gross** | Name of reporting person<br>**Phillip Gross** | |
| 2 | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | Check the appropriate box if a member of a Group (See Instructions)<br>[x] (a)<br>[ ] (b) | |
| 3 | SEC use only | SEC use only | |
| 4 | Source of funds (See Instructions)<br>**AF** | Source of funds (See Instructions)<br>**AF** | |
| 5 | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)<br>[ ] | |
| 6 | Citizenship or place of organization<br>**X1** | Citizenship or place of organization<br>**X1** | |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 7 | Sole Voting Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 8 | Shared Voting Power<br>**9097587.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 9 | Sole Dispositive Power<br>**0.00** |
| Number of Shares<br>Beneficially Owned by<br>Each Reporting Person With: | 10 | Shared Dispositive Power<br>**9097587.00** |
| 11 | Aggregate amount beneficially owned by each reporting person<br>**9097587.00** | Aggregate amount beneficially owned by each reporting person<br>**9097587.00** | |
| 12 | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)<br>[ ] | |
| 13 | Percent of class represented by amount in Row (11)<br>**6.13%** | Percent of class represented by amount in Row (11)<br>**6.13%** | |
| 14 | Type of Reporting Person (See Instructions)<br>**IN** | Type of Reporting Person (See Instructions)<br>**IN** | |

---

**Item 1. Security and Issuer**

**(a) Title of Class of Securities:**
Common Stock, par value $0.001 per share

**(b) Name of Issuer:**
89bio, Inc.

**(c) Address of Issuer's Principal Executive Offices:**
655 MONTGOMERY STREET, SUITE 1500, SAN FRANCISCO, CA, 94111

This statement on Schedule 13D (the "Schedule 13D") relates to the shares of common stock, par value $0.001 per share (the "Common Stock"), of 89bio, Inc., a Delaware corporation (the "Issuer").

**Item 4. Purpose of Transaction**

The Reporting Persons acquired the shares of Common Stock to which this Schedule 13D relates for investment purposes in the ordinary course of business, and not with the purpose nor with the effect of changing or influencing the control or management of the Issuer.  The Reporting Persons acquired the shares of Common Stock pursuant to investment strategies, including merger arbitrage and event driven strategies, because they believed that the shares of Common Stock reported herein, when purchased, represented an attractive investment opportunity. Accordingly, the Reporting Persons may not be eligible to report this position on a Schedule 13G. See Colish, Faith (No-Act., Available March 24, 1980). On September 18, 2025, the Issuer filed a Current Report on Form 8-K disclosing it had entered into an Agreement and Plan of Merger and Reorganization dated as of September 17, 2025 (the "Merger Agreement") with Roche Holdings, Inc., a Delaware corporation ("Parent"), and Bluefin Merger Subsidiary, Inc., a Delaware corporation and wholly owned subsidiary of Parent.  The transactions contemplated by the Merger Agreement are hereinafter referred to as the "Proposed Transaction".

Except as set forth herein, the Reporting Persons have no present plan or proposal that would relate to or result in any of the matters set forth in subparagraphs (a)-(j) of Item 4 of Schedule 13D. The Reporting Persons have not entered into any agreement with any third party to act together for the purpose of acquiring, holding, voting or disposing of the shares of Common Stock reported herein.  The Reporting Persons intend to review their investment in the Issuer on a continuing basis and may from time to time engage in discussions with management, the Board of Directors, other shareholders of the Issuer and other relevant parties, including representatives of any of the foregoing, concerning matters with respect to the Reporting Persons' investment in the shares of Common Stock, including, without limitation, the business, operations, governance, management, strategy and future plans of the Issuer. Depending on various factors, including, without limitation, the terms of the Proposed Transaction and any other offers or developments related thereto, the outcome of any discussions referenced above, the Issuer's financial position and strategic direction, actions taken by the Board of Directors, price levels of the shares of Common Stock, other investment opportunities available to the Reporting Persons, conditions in the securities market and general economic and industry conditions, the Reporting Persons may in the future take such actions with respect to their investment in the Issuer as they deem appropriate, including, without limitation, purchasing additional shares of Common Stock or selling some or all of their shares of Common Stock, engaging in short selling of or any hedging or similar transactions with respect to the shares of Common Stock and/or otherwise changing their intention with respect to any and all matters referred to in Item 4 of the Schedule 13D.  The Reporting Persons may, at any time and from time to time, review or reconsider their position and/or change their purpose and/or formulate plans or proposals with respect to their investment in the shares of Common Stock.

**Item 5. Interest in Securities of the Issuer**

**(a)**
See rows (11) and (13) of the cover pages to this Schedule 13D for the aggregate number of shares of Common Stock and percentages of the shares of Common Stock beneficially owned by each of the Reporting Persons.  The percentages used in this Schedule 13D are calculated based upon 148,492,428 shares of Common Stock outstanding as of September 16, 2025, as reported in the Merger Agreement attached as Exhibit 2.1 to the Issuer's Current Report on Form 8-K, filed with the SEC on September 18, 2025.

**(b)**
See rows (7) through (10) of the cover pages to this Schedule 13D for the number of shares of Common Stock as to which each Reporting Person has the sole or shared power to vote or direct the vote and sole or shared power to dispose or to direct the disposition.

**(c)**
The transactions in the shares of Common Stock within the past sixty (60) days by the Reporting Persons, which were all in the open market, are set forth in Schedule B, and are incorporated herein by reference.

**Item 6. Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer.**

Other than the Joint Filing Agreement attached as Exhibit 99.1 hereto, there are no contracts, arrangements, understandings or relationships (legal or otherwise) among the persons named in Item 2 hereof and between such persons and any person with respect to any securities of the Issuer, including any class of the Issuer's securities used as a reference security, in connection with any of the following: call options, put options, security-based swaps or any other derivative securities, transfer or voting of any of the securities, finder's fees, joint ventures, loan or option arrangements, guarantees of profits, division of profits or loss, or the giving or withholding of proxies.

### SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** Adage Capital Management, L.P.

**Signature:** /s/ Robert Atchinson

**Name/Title:** By: Adage Capital Partners LLC, its General Partner, By: Robert Atchinson, its Managing Member

**Date:** 10/03/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** Robert Atchinson

**Signature:** /s/ Robert Atchinson

**Name/Title:** Robert Atchinson, Individually

**Date:** 10/03/2025

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Reporting Person:** Phillip Gross

**Signature:** /s/ Phillip Gross

**Name/Title:** Phillip Gross, Individually

**Date:** 10/03/2025