# EDGAR Filing Document

**Accession Number:** 0001534248
**File Stem:** 0001178913-26-001550
**Filing Date:** 2026-3
**Character Count:** 25025
**Document Hash:** d9aeeca5dc8db6422c0994361fe9d8e3
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001178913-26-001550.hdr.sgml**: 20260319

**ACCESSION NUMBER**: 0001178913-26-001550

**CONFORMED SUBMISSION TYPE**: 6-K

**PUBLIC DOCUMENT COUNT**: 5

**CONFORMED PERIOD OF REPORT**: 20260319

**FILED AS OF DATE**: 20260319

**DATE AS OF CHANGE**: 20260319

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Chemomab Therapeutics Ltd.
- **CENTRAL INDEX KEY:** 0001534248
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 813676773
- **STATE OF INCORPORATION:** L3
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 6-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-38807
- **FILM NUMBER:** 26772472

**BUSINESS ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** KIRYAT ATIDIM, BUILDING 7
- **CITY:** TEL AVIV
- **PROVINCE COUNTRY:** L3
- **BUSINESS PHONE:** 972-77-331-0156

**MAIL ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** KIRYAT ATIDIM, BUILDING 7
- **CITY:** TEL AVIV
- **PROVINCE COUNTRY:** L3

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Anchiano Therapeutics Ltd.
- **DATE OF NAME CHANGE:** 20180906

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** BioCancell Ltd.
- **DATE OF NAME CHANGE:** 20111104

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### UNITED STATES

#### SECURITIES AND EXCHANGE COMMISSION <br> Washington, D.C. 20549
FORM 6-K

#### REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16<br> UNDER THE SECURITIES EXCHANGE ACT OF 1934
For the month of March 2026

Commission File Number 001-38807

**CHEMOMAB THERAPEUTICS LTD.**<br> (Translation of registrant's name into English)

#### 10 Habarzel Street, Building C, 10th Floor, Tel-Aviv, Israel
(Address of principal executive offices)

Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.

Form 20-F ☒ Form 40-F ☐

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#### EXPLANATORY NOTE
On March 19, 2026, Chemomab Therapeutics Ltd. (the "Registrant") issued a press release titled "Chemomab Therapeutics Announces Year End and Fourth Quarter 2025 Financial Results and Provides a Corporate Update", a copy of which is furnished as Exhibit 99.1 herewith.

The financial information included in the consolidated balance sheets and consolidated statements of operations contained in the press release attached as Exhibit 99.1 to this Report on Form 6-K is hereby incorporated by reference into the Registrant's Registration Statements on Form F-3 (File No. 333-275002 and 333-281750) and Form S-8 (File No. 333-259489 and No. 333-266868).

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#### EXHIBIT INDEX

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| | |
|:---|:---|
| <u>Exhibit</u> | <u>Description</u> |
| [99.1](exhibit_99-1.htm) | [Press release, dated March 19, 2026, titled "Chemomab Therapeutics Announces Year End and Fourth Quarter 2025 Financial Results and Provides a Corporate Update"](exhibit_99-1.htm) |

---

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SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

---

| | | |
|:---|:---|:---|
|  | **CHEMOMAB THERAPEUTICS LTD.** | **CHEMOMAB THERAPEUTICS LTD.** |
| Date: March 19, 2026 | By: | /s/ Sigal Fattal |
|  |  | Sigal Fattal |
|  |  | Chief Financial Officer |

---

![](image0.jpg)

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![](image1.jpg)

## Exhibit 99.1

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<u>**Exhibit 99.1**</u><br>

![](image00003.jpg)

#### Chemomab Therapeutics Announces Year End and

#### Fourth Quarter 2025 Financial Results and Provides a Corporate Update
*─Completed Successful FDA End-of-Phase 2 Meeting Following Positive Nebokitug Phase 2*

*SPRING Trial Results in Primary Sclerosing Cholangitis (PSC)─*

*─Achieved Alignment with FDA on Clear and Efficient Pathway to Potential Approval for the Treatment of PSC─*

*─Multiple Scientific Presentations and Publications Raised Awareness of Nebokitug's Potential to*

*Become the First Disease Modifying Treatment for PSC and Its Relevance to Other*

*Fibro-Inflammatory Conditions─*

*─Discussions with Strategic Partners Continue to Advance─*

**TEL AVIV, Israel, March 19, 2026** -- <u>Chemomab Therapeutics Ltd</u>. (Nasdaq: CMMB), a clinical stage biotechnology company developing innovative therapeutics for fibro-inflammatory diseases with high unmet need, today announced financial and operating results for the full year and fourth quarter ended December 31, 2025, and provided a corporate update.

"2025 was a critical year for Chemomab and our nebokitug program," said Adi Mor, PhD, co-founder and Chief Executive Officer of Chemomab. "Our Phase 2 SPRING trial data, viewed by many experts as the strongest to date in PSC, set the stage for our positive FDA End-of-Phase 2 meeting, which resulted in alignment on a clear pathway to potential regulatory approval based on a single Phase 3 trial. This pivotal trial will assess a primary composite endpoint comprised of well-characterized clinical events that are associated with disease progression in PSC. We believe that using a clinical event-driven endpoint helps de-risk the Phase 3 program, as key publications have linked the PSC-related biomarker improvements observed in nebokitug-treated patients in the SPRING trial with reductions in clinical events."

Dr. Mor added, "Our discussions with potential strategic partners continue to advance as we progress activities required for the timely initiation of the Phase 3 trial in PSC. In parallel, we are evaluating additional therapeutic indications where nebokitug has generated robust preclinical efficacy signals, providing a strong mechanistic and translational rationale for future clinical development."

#### 2025 and Recent Highlights:

&nbsp;&nbsp;&nbsp;&nbsp;• On December 2, 2025, Chemomab announced that the results of its Phase 2 SPRING trial were published in the *American Journal of Gastroenterology*. The study showed that nebokitug was generally safe and well tolerated and that patients treated
 with nebokitug had numerical improvements in a range of biomarkers for inflammation and fibrosis, particularly at the 20 mg/kg dose and in the pre-specified subgroup of patients with moderate/advanced fibrosis. The authors concluded
 that these promising data support further evaluation of nebokitug for the treatment of PSC in a Phase 3 clinical trial.

&nbsp;&nbsp;&nbsp;&nbsp;• On November 6, 2025, Chemomab reported that data from the Phase 2 SPRING trial assessing nebokitug for the treatment of PSC was featured in three poster presentations at the American Association for the Study of Liver Disease (AASLD) The
 Liver Meeting® 2025. All three were designated by conference organizers as "posters of distinction." Data presented from the SPRING trial open label extension showed the continued and consistent positive effects of nebokitug on key
 inflammatory and fibrotic biomarkers when administered to patients with PSC for up to 48 weeks, confirming its positive safety profile and further reinforcing its disease-modifying potential. Two other posters presented new clinical data
 that provided additional insights into the macrophage-related mechanism of action of nebokitug, a first-in-class antibody that inhibits the soluble protein CCL24, a key driver of disease processes in fibro-inflammatory diseases such as PSC.
 These results further confirm that nebokitug may halt or slow disease progression and improve clinical outcomes — the primary objectives of the proposed nebokitug Phase 3 PSC study.

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&nbsp;&nbsp;&nbsp;&nbsp;• On August 14, 2025, Chemomab reported that it would change the ratio of its American Depositary Shares ("ADSs") to its ordinary shares (the "ADS Ratio"), from the then current ADS Ratio of one ADS to 20 ordinary shares to a new ADS Ratio
 of one ADS to 80 ordinary shares, effective on August 26, 2025. This ratio adjustment essentially served as a one-for-four reverse ADS split for Chemomab ADS holders.

&nbsp;&nbsp;&nbsp;&nbsp;• On June 30, 2025, Chemomab reported that results of the Phase 2 SPRING trial assessing nebokitug for the treatment of PSC were presented in an oral session at BSG Live'25, the annual scientific meeting of the British Society for
 Gastroenterology. The data were presented by Douglas Thorburn, MD, Professor of Hepatology within the Institute for Liver and Digestive Health at UCL and Principal Investigator of the trial. Post-conference, it was announced that Professor
 Thorburn's talk on the SPRING trial results was awarded the prize for the Best Oral Presentation in its respective category.

&nbsp;&nbsp;&nbsp;&nbsp;• On June 11, 2025, Chemomab obtained confirmation from FDA on two development milestones for the nebokitug Phase 3 program. These included agreement with the FDA on the Chemistry, Manufacturing, and Controls (CMC) strategy proposed by
 Chemomab and its contract manufacturing partner and agreement that additional animal toxicology testing routinely required by FDA may be conducted in parallel with the nebokitug Phase 3 trial and submitted as part of the planned Biologics
 Licensing Application. This represents a favorable outcome for Chemomab and supports the timely advancement of the Phase 3 program.

&nbsp;&nbsp;&nbsp;&nbsp;• On June 3, 2025, Chemomab reported that two new patents covering the use of nebokitug for the treatment of liver diseases, including primary sclerosing cholangitis, were issued in China and Russia. These new patents further expand the
 protections provided by nebokitug's composition of matter and methods and use patents issued in the U.S., Europe, Japan and additional key territories.

&nbsp;&nbsp;&nbsp;&nbsp;• On May 5, 2025, Chemomab announced that data from the company's Phase 2 SPRING trial of nebokitug in PSC were presented in an oral Distinguished Abstract Plenary session at Digestive Disease Week® (DDW 2025). The DDW 2025 session
 presented data from the double-blind, placebo-controlled 15-week treatment period and the 48-week open label extension portion of the study.

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&nbsp;&nbsp;&nbsp;&nbsp;• On April 28, 2025, Chemomab reported two posters were presented at EASL 2025, the Annual Congress of the European Association for the Study of the Liver. In one study, proteomic analyses of 3,000 circulating proteins in patient samples
 from the SPRING trial showed that nebokitug-treated patients exhibited significant and dose-dependent changes in proteins playing a key role in fibrosis, immune cell recruitment and inflammation. These data highlight the broad impact of
 nebokitug's ability to neutralize CCL24, including reductions in a wide array of inflammatory and fibrotic biomarkers in treated patients. The second study analyzed the pharmacodynamics and pharmacokinetics of nebokitug and CCL24 using data
 from the SPRING trial. These analyses indicated effective antibody-target engagement and regression analyses revealed that increasing patient exposure to nebokitug was associated with decreasing levels of PSC disease biomarkers.

&nbsp;&nbsp;&nbsp;&nbsp;• On April 15, 2025, Chemomab announced new executive medical and clinical appointments. David M. Weiner, MD, rejoined Chemomab as Interim Chief Medical Officer, bringing extensive biotechnology and pharmaceutical industry R&D, drug
 development and strategic experience, and Jack Lawler, who oversaw the conduct of Chemomab's successful Phase 2 SPRING Trial in PSC, was promoted to the position of Chief Development Officer.

&nbsp;&nbsp;&nbsp;&nbsp;• On February 19, 2025, Chemomab reported that the International Nonproprietary Names (INN) program of the World Health Organization had assigned the INN designation nebokitug to the company's lead product candidate CM-101.

&nbsp;&nbsp;&nbsp;&nbsp;• On February 19, 2025, Chemomab announced the successful completion of its End-of-Phase 2 Meeting with the U.S. Food and Drug Administration (FDA) and alignment with FDA on the design of a Phase 3 registration study for nebokitug for the
 treatment of PSC. The design provides clarity on a streamlined path to full regulatory approval based on a single pivotal trial. The primary endpoint measures time-to-first clinical event and encompasses multiple clinical events associated
 with disease progression. Key publications have shown that the reductions in PSC biomarkers seen in the nebokitug Phase 2 SPRING trial are associated with reductions in clinical events, increasing confidence in the relevance of this
 approach for the nebokitug Phase 3 program.

&nbsp;&nbsp;&nbsp;&nbsp;• On January 13, 2025, a peer-reviewed publication in the journal *Cells* further confirmed the key role of the soluble protein CCL24 in driving the fibro-inflammatory pathologies underlying PSC,
 systemic sclerosis and other fibrotic diseases *.* The review describes the pivotal function CCL24 plays in initiating and advancing fibrotic processes, highlighting its impact on fibrotic, immune and
 vascular pathways. It also presented preclinical and clinical evidence supporting the therapeutic potential of blocking CCL24 with agents like nebokitug in diseases that involve excessive inflammation and fibrosis, such as PSC and systemic
 sclerosis.

#### Full Year and Fourth Quarter 2025 Financial Highlights:
&nbsp;&nbsp;&nbsp;&nbsp;• **Cash Position:** Cash, cash equivalents and short-term bank deposits were $10.4 million as of December 31, 2025 compared to $14.3 million as of December 31, 2024. The current cash runway is expected
 to take the Company through the end of the first quarter of 2027.

&nbsp;&nbsp;&nbsp;&nbsp;• **Research and Development (R&D) Expenses:** R&D expenses were $1.1 million for the fourth quarter and $5.8 million for the full year ended December 31, 2025, compared to $2.4 million and $11.3
 million for the respective periods in 2024. The decrease in R&D expenses in the fourth quarter and full year of 2025 compared to the comparable periods in 2024 primarily resulted from decreased clinical costs as the company's nebokitug
 Phase 2 PSC trial was completed.

&nbsp;&nbsp;&nbsp;&nbsp;• **General and Administrative (G&A) Expenses**: G&A expenses were $0.9 million for the fourth quarter and $3.7 million for the full year ended December 31, 2025, compared to $0.8 million and
 $3.4 million for the fourth quarter and full year in 2024.

&nbsp;&nbsp;&nbsp;&nbsp;• **Net Loss**: Net loss was
 $1.9 million, or a net loss of less than $0.01 per basic and diluted Ordinary Share, for the fourth quarter and $9.0 million, or a net loss of less than $0.02 per basic and diluted Ordinary Share, for the full year ended December 31,
 2025, compared to a net loss of $3.0 million, or a net loss of less than $0.01 per basic and diluted Ordinary Share, for the fourth quarter of 2024, and $13.9 million, or a net loss of $0.04 per basic and diluted Ordinary Share, for the
 full year ended December 31, 2024.

&nbsp;&nbsp;&nbsp;&nbsp;• **Number of Issued and Outstanding Shares**: As of December 31, 2025, the company had 575,381,320 Ordinary Shares issued and outstanding (equal to 7,192,267 ADSs), compared to 377,132,220 Ordinary Shares issued and outstanding (equal to 4,714,153 ADSs)
 as of December 31, 2024.

For further details on the company's financial results for the year ended December 31, 2025, please refer to the company's annual report on Form 20-F, which will be filed with the SEC on or around March 23, 2026.

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#### Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995 that involve substantial risks and uncertainties. All statements other than statements of historical facts contained in this press release, including statements regarding our future financial condition, results of operations, business strategy and plans, and objectives of management for future operations, as well as statements regarding industry trends, are forward-looking statements. In some cases, you can identify forward-looking statements by terminology such as "estimate," "intend," "may," "plan," "potentially," "will" or the negative of these terms or other similar expressions. We have based these forward-looking statements largely on our current expectations and projections about future events and trends that we believe may affect our financial condition, results of operations, business strategy and financial needs. These forward-looking statements are subject to a number of risks, uncertainties and assumptions, including, among other things: the risk that certain acknowledgements from the End-of-Phase 2 (EOP2) meeting with the FDA in connection with PSC regulatory approval will not materialize into a pathway for regulatory approval; that certain conclusions and assumptions drawn from the EOP2 meeting with the FDA discussed in the Company's press releases will prove incorrect and adversely affect the ability for nebokitug to become an FDA fully approved therapy; the risk that the full data set from the nebokitug study or data generated in further clinical trials of nebokitug will not be consistent with the topline results of the nebokitug Phase 2 PSC trial; failure to obtain, or delays in obtaining, regulatory approvals for nebokitug in the U.S., Europe or other territories; failure to successfully commercialize nebokitug, if approved by applicable regulatory authorities, in the U.S., Europe or other territories, or to maintain U.S., European or other territory regulatory approval for nebokitug if approved; uncertainties in the degree of market acceptance of nebokitug by physicians, patients, third-party payors and others in the healthcare community; nebokitug development of unexpected safety or efficacy concerns related to nebokitug; failure to successfully conduct future clinical trials for nebokitug, including due to the Company's potential inability to obtain sufficient financing from investors or strategic partners, or to enroll or retain sufficient patients to conduct and complete the trials or generate data necessary for regulatory approval, among other things; risks that the Company's clinical studies will be delayed or that serious side effects will be identified during drug development; failure of third parties on which the Company is dependent to manufacture sufficient quantities of nebokitug for commercial or clinical needs, to conduct the Company's clinical trials; changes in laws and regulations applicable to the Company's business and failure to comply with such laws and regulations; business or economic disruptions due to catastrophes or other events, including natural disasters or public health crises; and uncertainties with respect to the Company's need and ability to access future capital; and the intensity and duration of the current war in the Middle East, and its impact on our operations in Israel. These risks are not exhaustive. You should carefully consider the risks and uncertainties described in the "Risk Factors" sections of our 20-F for the year ended December 31, 2025. New risk factors emerge from time to time, and it is not possible for our management to predict all risk factors, nor can we assess the impact of all factors on our business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in, or implied by, any forward-looking statements. You should not rely upon forward-looking statements as predictions of future events. Except as required by law, we undertake no obligation to update publicly any forward-looking statements for any reason after the date of this press release. Before you invest, you should read the documents we have filed and will file with the SEC for more complete information about us. You may get these documents for free by visiting EDGAR on the SEC website at <u>www.sec.gov</u>. This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation, or sale would be unlawful prior to registration or qualification under the securities law of any such state or jurisdiction.

#### About Chemomab Therapeutics Ltd.
Chemomab is a clinical stage biotechnology company developing innovative therapeutics for fibro-inflammatory diseases with high unmet need. Based on the unique role of the soluble protein CCL24 in promoting fibrosis and inflammation, Chemomab developed nebokitug, a first-in-class dual activity monoclonal antibody that neutralizes CCL24 and has demonstrated disease-modifying potential. In clinical and preclinical studies, nebokitug has been shown to have a favorable safety profile and has been generally well-tolerated, with the potential to treat multiple severe and life-threatening fibro-inflammatory diseases. Chemomab has reported positive results from five clinical trials of nebokitug. Based on positive data from its Phase 2 SPRING trial in primary sclerosing cholangitis (PSC), Chemomab and the FDA have aligned on the design of a nebokitug Phase 3 registration trial in patients with PSC. Nebokitug has received FDA and EMA Orphan Drug and FDA Fast Track designations for the treatment of PSC. Chemomab's nebokitug program for the treatment of systemic sclerosis has received FDA and EMA Orphan Drug designations and has an open U.S. IND. For more information, visit: <u>chemomab.com</u>.

#### Contacts:

#### Media and Investors:
Barbara Lindheim

Consulting Vice President, Investor & Public Relations, Strategic Communications

Phone: +1 917-355-9234

<u>barbara.lindheim@chemomab.com</u>

<u>IR@chemomab.com</u>

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Chemomab Therapeutics Ltd. and its subsidiaries

Consolidated Balance Sheets as of

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In USD thousands (except share and per share amounts)

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| | | |
|:---|:---|:---|
|  | **December 31,**<br>2025 | **December 31,**<br>2024 |
| **Assets** |  |  |
| **Current assets** |  |  |
| Cash and cash equivalents | **7564** | 6071 |
| Short-term bank deposit | **2802** | 8195 |
| Restricted cash | **-** | 76 |
| Other receivables and prepaid expenses | 3059 | 1698 |
| **Total current assets** | 13425 | 16040 |
| **Non-current assets** |  |  |
| Long-term prepaid expenses | **211** | 385 |
| Property and equipment, net | **176** | 250 |
| Operating lease right-of-use assets | - | 289 |
| **Total non-current assets** | 387 | 924 |
| **Total assets** | 13812 | 16964 |
| **Current liabilities** |  |  |
| Trade payables | **485** | 633 |
| Accrued expenses | **337** | 1536 |
| Employee and related expenses | **656** | 934 |
| Operating lease liabilities | - | 115 |
| **Total current liabilities** | 1478 | 3218 |
| <br> **Non-current liabilities** |  |  |
| Non-current operating lease liabilities | - | 209 |
| **Total non-current liabilities** | - | 209 |
| **Commitments and contingent liabilities** |  |  |
| **Total liabilities** | 1478 | 3427 |
| **Shareholders' equity** |  |  |
| Ordinary Shares no par value - Authorized: 4,650,000,000 as of December 31, 2025, and December 31, 2024. |  |  |
| Issued and outstanding: 575,381,320, and 377,132,220 Ordinary shares of December 31, 2025 and 2024, respectively (\*) | - | - |
| Additional paid-in capital | **123952** | 116160 |
| Accumulated deficit | (111618) | (102623) |
| **Total shareholders' equity** | 12334 | 13537 |
| **Total liabilities and shareholders' equity** | 13812 | 16964 |

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(\*) 1 American Depositary Share (ADS) represents 80 Ordinary Shares

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Consolidated Statements of Operations

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In USD thousands (except share and per share amounts) <br>

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| | | | | |
|:---|:---|:---|:---|:---|
|  | **Three months**<br>**December 31**<br>2025 | **Three months**<br>**December 31**<br>2024 | **Year Ended**<br>**December 31**<br>2025 | **Year Ended**<br>**December 31**<br>2024 |
|  | Unaudited | Unaudited | Unaudited | Audited |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Operating expenses** |  |  |  |  |
| Research and development | **1093** | 2411 | **5833** | 11327 |
| General and administrative | 881 | 802 | 3734 | 3412 |
| **Total operating expenses** | **1974** | 3213 | **9567** | 14739 |
| Financing income, net | (101) | (250) | (572) | (794) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; ` |  |  |  |  |
| **Net loss** | 1873 | 2963 | 8995 | 13945 |
| Basic and diluted loss per Ordinary Share | 0.003 | <br>0.008<br>| 0.018 | <br>0.039<br>|
|  | <br>625680763<br>| 377132220 | <br>510227715<br>| 359048638 |

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(\*) 1 American Depositary Share (ADS) represents 80 Ordinary Shares

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