# EDGAR Filing Document

**Accession Number:** 0001615055
**File Stem:** 0001140361-23-012839
**Filing Date:** 2023-3
**Character Count:** 6666
**Document Hash:** 21af731e5b7ff824d0e359fe5799a5b5
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001140361-23-012839.hdr.sgml**: 20230321

**ACCESSION NUMBER**: 0001140361-23-012839

**CONFORMED SUBMISSION TYPE**: S-8 POS

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20230321

**DATE AS OF CHANGE**: 20230321

**EFFECTIVENESS DATE**: 20230321

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** IsoPlexis Corp
- **CENTRAL INDEX KEY:** 0001615055
- **STANDARD INDUSTRIAL CLASSIFICATION:** LABORATORY ANALYTICAL INSTRUMENTS [3826]
- **IRS NUMBER:** 462179799
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8 POS
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-264180
- **FILM NUMBER:** 23750542

**BUSINESS ADDRESS:**
- **STREET 1:** 35 NE INDUSTRIAL ROAD
- **CITY:** BRANFORD
- **STATE:** CT
- **ZIP:** 06405
- **BUSINESS PHONE:** 203-208-4111

**MAIL ADDRESS:**
- **STREET 1:** 35 NE INDUSTRIAL ROAD
- **CITY:** BRANFORD
- **STATE:** CT
- **ZIP:** 06405

#### As filed with the Securities and Exchange Commission on March 21 , 2023

#### <br>

#### Registration No. 333-260161

#### Registration No. 333-264180

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### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION

#### WASHINGTON, D.C. 20549

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#### POST-EFFECTIVE AMENDMENT NO. 1 TO:

#### Form S-8 Registration Statement No. 333-260161

#### Form S-8 Registration Statement No. 333-264180

#### UNDER

#### THE SECURITIES ACT OF 1933

## IsoPlexis Corporation

#### (Exact name of registrant as specified in its charter)

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| | |
|:---|:---|
| **Delaware** | **46-2179799** |
| **(State or other jurisdiction of incorporation or organization)** | **(IRS Employer Identification No.)** |

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#### <br>

#### 35 NE Industrial Road

#### Branford, Connecticut 06405

#### (Address of Principal Executive Offices, Including Zip Code)

#### IsoPlexis Corporation 2014 Stock Plan

#### IsoPlexis Corporation 2021 Omnibus Incentive Compensation Plan

#### IsoPlexis Corporation 2021 Employee Stock Purchase Plan

#### (Full title of the plans)

#### <br>

#### Scott Chaplin

#### Chief Legal Officer

#### IsoPlexis Corporation

#### 35 NE Industrial Road

#### Branford, Connecticut 06405
(203) 208-4111

#### (Name, address and telephone number, including area code, of agent for service)

#### <br>

#### Please send copies of all communications to:

#### <br>

#### Damien R. Zoubek

#### Oliver J. Board

#### Freshfields Bruckhaus Deringer US LLP

#### 601 Lexington Avenue, 31st Floor

#### New York, New York 10022

Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

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| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☐ | Accelerated filer | ☐ |
| Non-accelerated filer | ☒ | Smaller reporting company | ☒ |
|  |  | Emerging growth company | ☒ |

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If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

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#### EXPLANATORY NOTE AND DEREGISTRATION OF UNSOLD SECURITIES
These Post-Effective Amendments relate to the deregistration of all shares of common stock, $0.001 par value per share ("<u>Common Stock</u>"), of IsoPlexis Corporation, a Delaware corporation (the "<u>Company</u>" or the "<u>Registrant</u>"), remaining unsold or otherwise unissued under the following Registration Statements on Form S-8 (collectively, the "<u>Registration Statements</u>") filed by the Company with the Securities and Exchange Commission (the "<u>SEC</u>"):

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| | | | |
|:---|:---|:---|:---|
| File No. | **Date Originally Filed**<br> **with the SEC** | **Name of Equity Plan or Agreement** | **Shares of**<br> **Common Stock** |
| **333-260161** | October 8, 2021 | IsoPlexis Corporation 2014 Stock Plan | 5113324 |
|  |  | IsoPlexis Corporation 2021 Omnibus Incentive Compensation Plan | 3271801 |
|  |  | IsoPlexis Corporation 2021 Employee Stock Purchase Plan | 389500 |
| **333-264180** | April 7, 2022 | IsoPlexis Corporation 2021 Omnibus Incentive Compensation Plan | 1951800 |
|  |  | IsoPlexis Corporation 2021 Employee Stock Purchase Plan | 390360 |

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On March 21, 2023, pursuant to the Agreement and Plan of Merger, dated as of December 21, 2022 (the "<u>Merger Agreement</u>"), by and among Berkeley Lights, Inc., a Delaware corporation ("<u>Parent</u>"), Iceland Merger Sub Inc., a Delaware corporation and a wholly owned subsidiary of Parent ("<u>Merger Sub</u>"), and the Company, Merger Sub merged with and into the Company (the "<u>Merger</u>"), with the Company surviving the Merger as a wholly owned subsidiary of Parent.

As a result of the Merger and the related transactions contemplated by the Merger Agreement, the Company has terminated any and all offerings of the Company's securities pursuant to the Registration Statements. In accordance with undertakings made by the Company in the Registration Statements to remove from registration, by means of a post-effective amendment, any securities that had been registered for issuance under the Registration Statements that remain unsold at the termination of the offerings, the Company hereby removes from registration all such securities of the Company registered but unsold or otherwise unissued under the Registration Statements, if any, as of the date hereof. The Registration Statements are hereby amended to reflect the deregistration of such securities, and the Company hereby terminates the effectiveness of the Registration Statements. <br>

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#### SIGNATURES

#### <br>
Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused these Post-Effective Amendments to the Registration Statements on Form S-8 to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Branford, State of Connecticut, on March 21, 2023.

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| | |
|:---|:---|
| **ISOPLEXIS CORPORATION** | **ISOPLEXIS CORPORATION** |
| By: | /s/ Scott Chaplin |

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<br>Name: Scott Chaplin <br>Title: Chief Legal Officer

No other person is required to sign these Post-Effective Amendments to the Registration Statements in reliance upon Rule 478 under the Securities Act of 1933, as amended.

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