# EDGAR Filing Document

**Accession Number:** 0001855655
**File Stem:** 0001104659-23-021867
**Filing Date:** 2023-2
**Character Count:** 13798
**Document Hash:** 3da100ea729d056610cd6beb2c74ba74
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-23-021867.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001104659-23-021867

**CONFORMED SUBMISSION TYPE**: SC 13G/A

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**GROUP MEMBERS**: DR. SENAI ASEFAW

**GROUP MEMBERS**: PARADIGM BIOCAPITAL ADVISORS GP LLC

**GROUP MEMBERS**: PARADIGM BIOCAPITAL INTERNATIONAL FUND LTD.

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Vor Biopharma Inc.
- **CENTRAL INDEX KEY:** 0001817229
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G/A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-92269
- **FILM NUMBER:** 23631001

**BUSINESS ADDRESS:**
- **STREET 1:** 100 CAMBRIDGEPARK DRIVE
- **STREET 2:** SUITE 101
- **CITY:** CAMBRIDGE
- **STATE:** MA
- **ZIP:** 02140
- **BUSINESS PHONE:** 617-655-6580

**MAIL ADDRESS:**
- **STREET 1:** 100 CAMBRIDGEPARK DRIVE
- **STREET 2:** SUITE 101
- **CITY:** CAMBRIDGE
- **STATE:** MA
- **ZIP:** 02140
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Paradigm Biocapital Advisors LP
- **CENTRAL INDEX KEY:** 0001855655
- **IRS NUMBER:** 851451055
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G/A

**BUSINESS ADDRESS:**
- **STREET 1:** 767 THIRD AVENUE, 17TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10017
- **BUSINESS PHONE:** 646-970-2123

**MAIL ADDRESS:**
- **STREET 1:** 767 THIRD AVENUE, 17TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10017

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**SCHEDULE 13G**

Under the Securities Exchange Act of 1934

(Amendment No. 1)\*

**<u>Vor Biopharma Inc.</u>**

(Name of Issuer)

**<u>Common Stock, $0.0001 par value per share</u>**

(Title of Class of Securities)

**<u>929033108</u>**

(CUSIP Number)

**<u>December 31, 2022</u>**

(Date of Event Which Requires Filing of this statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

◻ Rule 13d-1(b)

⌧ Rule 13d-1(c)

◻ Rule 13d-1(d)

\* The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

CUSIP No. 929033108

1. Names of Reporting Persons

Paradigm BioCapital Advisors LP

2. Check the Appropriate Box if a Member of a Group (See Instructions)

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) ◻

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ⌧

3. SEC Use Only

4. Citizenship or Place of Organization

Delaware

---

| | | |
|:---|:---|:---|
| NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY<br> EACH <br> REPORTING <br> PERSON WITH: | 5. SOLE VOTING POWER | 6477999 |
| NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY<br> EACH <br> REPORTING <br> PERSON WITH: | 6. SHARED VOTING POWER | 0 |
| NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY<br> EACH <br> REPORTING <br> PERSON WITH: | 7. SOLE DISPOSITIVE POWER | 6477999 |
| NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY<br> EACH <br> REPORTING <br> PERSON WITH: | 8. SHARED DISPOSITIVE POWER | 0 |

---

9. Aggregate Amount Beneficially Owned by Each Reporting Person

6,477,999

10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares
(See Instructions) ◻

11. Percent of Class Represented by Amount in Row (9)

9.9%

12. Type of Reporting Person (See Instructions)

PN

\* The information above is given as of the end of business on February 14, 2023, the filing date of this Schedule 13G.

Page 2 of 8 Pages

CUSIP No. 929033108

1. Names of Reporting Persons

Paradigm BioCapital Advisors GP LLC

2. Check the Appropriate Box if a Member of a Group (See Instructions)

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) ◻

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ⌧

3. SEC Use Only

4. Citizenship or Place of Organization

Delaware

---

| | | |
|:---|:---|:---|
| NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY<br> EACH <br> REPORTING <br> PERSON WITH: | 5. SOLE VOTING POWER | 6477999 |
| NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY<br> EACH <br> REPORTING <br> PERSON WITH: | 6. SHARED VOTING POWER | 0 |
| NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY<br> EACH <br> REPORTING <br> PERSON WITH: | 7. SOLE DISPOSITIVE POWER | 6477999 |
| NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY<br> EACH <br> REPORTING <br> PERSON WITH: | 8. SHARED DISPOSITIVE POWER | 0 |

---

9. Aggregate Amount Beneficially Owned by Each Reporting Person

6,477,999

10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares
(See Instructions) ◻

11. Percent of Class Represented by Amount in Row (9)

9.9%

12. Type of Reporting Person (See Instructions)

OO

\* The information above is given as of the end of business on February 14, 2023, the filing date of this Schedule 13G.

Page 3 of 8 Pages

CUSIP No. 929033108

1. Names of Reporting Persons

Dr. Senai Asefaw

2. Check the Appropriate Box if a Member of a Group (See Instructions)

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) ◻

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ⌧

3. SEC Use Only

4. Citizenship or Place of Organization

USA

---

| | | |
|:---|:---|:---|
| NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY<br> EACH <br> REPORTING <br> PERSON WITH: | 5. SOLE VOTING POWER | 6477999 |
| NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY<br> EACH <br> REPORTING <br> PERSON WITH: | 6. SHARED VOTING POWER | 0 |
| NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY<br> EACH <br> REPORTING <br> PERSON WITH: | 7. SOLE DISPOSITIVE POWER | 6477999 |
| NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY<br> EACH <br> REPORTING <br> PERSON WITH: | 8. SHARED DISPOSITIVE POWER | 0 |

---

9. Aggregate Amount Beneficially Owned by Each Reporting Person

6,477,999

10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares
(See Instructions) ◻

11. Percent of Class Represented by Amount in Row (9)

9.9%

12. Type of Reporting Person (See Instructions)

IN

\* The information above is given as of the end of business on February 14, 2023, the filing date of this Schedule 13G.

Page 4 of 8 Pages

CUSIP No. 929033108

1. Names of Reporting Persons

Paradigm BioCapital International Fund Ltd.

2. Check the Appropriate Box if a Member of a Group (See Instructions)

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) ◻

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ⌧

3. SEC Use Only

4. Citizenship or Place of Organization

Cayman Islands

---

| | | |
|:---|:---|:---|
| NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY<br> EACH <br> REPORTING <br> PERSON WITH: | 5. SOLE VOTING POWER | 4801049 |
| NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY<br> EACH <br> REPORTING <br> PERSON WITH: | 6. SHARED VOTING POWER | 0 |
| NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY<br> EACH <br> REPORTING <br> PERSON WITH: | 7. SOLE DISPOSITIVE POWER | 4801049 |
| NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY<br> EACH <br> REPORTING <br> PERSON WITH: | 8. SHARED DISPOSITIVE POWER | 0 |

---

9. Aggregate Amount Beneficially Owned by Each Reporting Person

4,801,049

10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares
(See Instructions) ◻

11. Percent of Class Represented by Amount in Row (9)

7.3%

12. Type of Reporting Person (See Instructions)

CO

\* The information above is given as of the end of business on February 14, 2023, the filing date of this Schedule 13G.

Page 5 of 8 Pages

**Item 1.**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) The name of the issuer is Vor Biopharma Inc. (the "*Issuer* ").

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) The principal executive offices of the Issuer are located at 100 Cambridge Park Drive, Suite 101,Cambridge, MA 02140.

**Item 2.**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) This Schedule 13G is filed by the following (the "*Reporting Persons* "): (1) Paradigm BioCapital Advisors LP (the "*Adviser* "); (2) Paradigm BioCapital Advisors GP LLC (the "*GP* "); (3) Dr. Senai Asefaw, and (4) Paradigm BioCapital International Fund Ltd. (the "*Fund* "). The Fund is a private investment vehicle. The Fund and a separately managed account managed by the Adviser (the "*Account*") directly beneficially own the Common Stock (as defined below) reported in this Statement. The Adviser is the investment manager of the Fund and the Account. The GP is the general partner of the Adviser. Dr. Senai Asefaw is the managing member of the GP. The Adviser, the GP and Dr. Asefaw may be deemed to beneficially own the Common Stock directly beneficially owned by the Fund and the Account. Each Reporting Person disclaims beneficial ownership with respect to any Common Stock other than the Common Stock directly beneficially owned by such Reporting Person.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) The principal business office of the Reporting Persons is 767 Third Avenue, 17<sup>th</sup> Floor, New York, NY 10017.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) For citizenship information see Item 4 of the cover page of each Reporting Person.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) This statement relates to the Common Stock, $0.0001 par value per share, of the Issuer (the "*Common Stock* ").

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) The CUSIP Number of the Common Stock is 929033108.

**Item 3. If this statement is filed pursuant to 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:**

(a) □ Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).

(b) □ Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).

(c) □ Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).

(d) □ Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8).

(e) □ An investment adviser in accordance with 240.13d-1(b)(1)(ii)(E);

(f) □ An employee benefit plan or endowment fund in accordance with 240.13d-1(b)(1)(ii)(F);

(g) □ A parent holding company or control person in accordance with 240.13d-1(b)(1)(ii)(G);

(h) □ A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);

(i) □ A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);

(j) □ A non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J);

(k) □ Group, in accordance with §240.13d-1(b)(1)(ii)(K).

If filing as a non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J), please specify the type of institution: <u>___________________________</u>

Page 6 of 8 Pages

**Item 4. Ownership.**

See Items 5-9 and 11 on the cover page for each Reporting Person and Item 2, which information is given as of end of business on February 14, 2023, the date of filing of this Schedule 13G. On the Event Date of December 31, 2022, the Reporting Persons collectively beneficially owned 6,442,825 shares of Common Stock, representing 9.9% of the outstanding shares of Common Stock.

The percentages of beneficial ownership contained herein are based on 65,323,385 shares of Common Stock outstanding as of December 23, 2022, as reported in the Issuer's Prospectus Supplement filed with the SEC on December 23, 2022.

**Item 5. Ownership of Five Percent or Less of a Class.**

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following: ¨

**Item 6. Ownership of More than Five Percent on Behalf of Another Person.**

Not applicable.

**Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company.**

Not applicable.

**Item 8. Identification and Classification of Members of the Group.**

Not applicable.

**Item 9. Notice of Dissolution of Group.**

Not applicable.

**Item 10. Certification.**

(a) Not applicable.

(b) Not applicable.

&nbsp;&nbsp;&nbsp;&nbsp;(c) By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under §240.14a-11.

Page 7 of 8 Pages

**SIGNATURE**

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Dated: February 14, 2023

Paradigm BioCapital Advisors LP

Paradigm BioCapital Advisors GP LLC

Paradigm BioCapital International Fund Ltd.

---

| | |
|:---|:---|
| By: | /s/ David K. Kim |

---

Name: David K. Kim

Title: Authorized Signatory

/s/ Dr. Senai Asefaw

Dr. Senai Asefaw

Page 8 of 8 Pages