# EDGAR Filing Document

**Accession Number:** 0001515673
**File Stem:** 0000950170-23-003098
**Filing Date:** 2023-2
**Character Count:** 20198
**Document Hash:** 4c385049150d6a57237ca50254fbf9a3
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000950170-23-003098.hdr.sgml**: 20230217

**ACCESSION NUMBER**: 0000950170-23-003098

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 6

**FILED AS OF DATE**: 20230217

**DATE AS OF CHANGE**: 20230216

**EFFECTIVENESS DATE**: 20230217

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Ultragenyx Pharmaceutical Inc.
- **CENTRAL INDEX KEY:** 0001515673
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 272546083
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-269840
- **FILM NUMBER:** 23639708

**BUSINESS ADDRESS:**
- **STREET 1:** 60 LEVERONI COURT
- **CITY:** NOVATO
- **STATE:** CA
- **ZIP:** 94949
- **BUSINESS PHONE:** 415-483-8800

**MAIL ADDRESS:**
- **STREET 1:** 60 LEVERONI COURT
- **CITY:** NOVATO
- **STATE:** CA
- **ZIP:** 94949

**As filed with the Securities and Exchange Commission on February 16, 2023**

**Registration No. 333-**

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**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**WASHINGTON, DC 20549** 

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**FORM S-8**

**REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933**

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**Ultragenyx Pharmaceutical Inc.**

(Exact name of registrant as specified in its charter)

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| | |
|:---|:---|
| &nbsp;&nbsp;**Delaware**<br> (State or Other Jurisdiction of Incorporation or Organization) | &nbsp;&nbsp;**27-2546083**<br>(I.R.S. Employer Identification No.) |

---

**60 Leveroni Court**

**Novato, CA 94949**

(Address of Principal Executive Offices, Zip Code)

**2014 Incentive Plan**

**2014 Employee Stock Purchase Plan**

(Full title of the plan)

**Emil D. Kakkis, M.D., Ph.D.**

**President and Chief Executive Officer**

**Ultragenyx Pharmaceutical Inc.**

**60 Leveroni Court**

**Novato, CA 94949**

**(415) 483-8800**

(Name, address, including zip code, and telephone number, including area code, of agent for service)

Copies to:

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| | |
|:---|:---|
| Karah Parschauer<br>Executive Vice President and Chief Legal Officer<br>Ultragenyx Pharmaceutical Inc.<br>60 Leveroni Court<br>Novato, CA 94949<br>Telephone: (415) 483-8800<br>Facsimile: (415) 483-8810 | Ryan A. Murr, Esp.<br>Gibson, Dunn & Crutcher LLP<br>555 Mission Street, Suite 3000<br>San Francisco, CA 94105-0921<br>Telephone: (415) 393-8200<br>Facsimile: (415) 393-8306 |

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_______________________________________

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer", "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.

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| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☒ | Accelerated filer | ☐ |
| Non-accelerated filer | ☐ | Smaller reporting company | ☐ |
|  |  | Emerging growth company | ☐ |
| If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐ | If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐ | If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐ | If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐ |

---

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**EXPLANATORY NOTE**

This Registration Statement on Form S-8 (this "Registration Statement") registers additional shares of common stock, par value $0.001 per share ("Common Stock") of Ultragenyx Pharmaceutical Inc. (the "Registrant") to be issued pursuant to the Ultragenyx Pharmaceutical Inc. 2014 Incentive Plan (as amended, the "2014 Plan") and the Ultragenyx Pharmaceutical Inc. 2014 Employee Stock Purchase Plan (as amended, the "ESPP"). The information contained in the Registrant's registration statements on Form S-8 filed with the Securities and Exchange Commission (the "SEC") (SEC File Nos. [<u>333-194773</u>](https://www.sec.gov/Archives/edgar/data/1515673/000119312514112551/d692808ds8.htm), [<u>333-201843</u>](https://www.sec.gov/Archives/edgar/data/1515673/000119312515031867/d852721ds8.htm), [<u>333-209729</u>](https://www.sec.gov/Archives/edgar/data/1515673/000119312516478799/d131877ds8.htm), [<u>333-216110</u>](https://www.sec.gov/Archives/edgar/data/1515673/000156459017001715/rare-s8.htm), [<u>333-223124</u>](https://www.sec.gov/Archives/edgar/data/1515673/000156459018002676/rare-s8.htm), [<u>333-229746</u>](https://www.sec.gov/Archives/edgar/data/1515673/000156459019003350/rare-s8.htm), [<u>333-236428</u>](https://www.sec.gov/Archives/edgar/data/1515673/000156459020004686/rare-s8.htm), [<u>333-253007</u>](https://www.sec.gov/Archives/edgar/data/0001515673/000156459021005615/rare-s8.htm) and [<u>333-262751</u>](https://www.sec.gov/Archives/edgar/data/1515673/000156459022005225/rare-s8.htm)) together with all exhibits filed therewith or incorporated therein by reference, are hereby incorporated by reference pursuant to General Instruction E to Form S-8, and the shares of Common Stock registered hereunder are in addition to the shares of Common Stock registered on such registration statements.

**PART II<br>INFORMATION REQUIRED IN THE REGISTRATION STATEMENT**

**Item 8. Exhibits.** 

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| | | | | | |
|:---|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;**Exhibit No.** | &nbsp;&nbsp;**Exhibit Description** | &nbsp;&nbsp;**Incorporated by Reference** | &nbsp;&nbsp;**Incorporated by Reference** | &nbsp;&nbsp;**Incorporated by Reference** | &nbsp;&nbsp;**Filed Herewith** |
| &nbsp;&nbsp;**Exhibit No.** | &nbsp;&nbsp;**Exhibit Description** | &nbsp;&nbsp;**Form** | &nbsp;&nbsp;**Date** | &nbsp;&nbsp;**Number** | &nbsp;&nbsp;**Filed Herewith** |
| &nbsp;&nbsp;4.1 | &nbsp;&nbsp;[<u>Amended and Restated Certificate of Incorporation of Ultragenyx Pharmaceutical Inc.</u>](https://www.sec.gov/Archives/edgar/data/1515673/000119312514036944/d670959dex31.htm) | &nbsp;&nbsp;8-K | &nbsp;&nbsp;2/5/2014 | &nbsp;&nbsp;3.1 |  |
| &nbsp;&nbsp;4.2 | &nbsp;&nbsp;[<u>Amended and Restated Bylaws of Ultragenyx Pharmaceutical Inc.</u>](https://www.sec.gov/Archives/edgar/data/1515673/000119312514036944/d670959dex32.htm) | &nbsp;&nbsp;8-K | &nbsp;&nbsp;2/5/2014 | &nbsp;&nbsp;3.2 |  |
| &nbsp;&nbsp;4.3 | &nbsp;&nbsp;[<u>Form of Common Stock Certificate</u>](https://www.sec.gov/Archives/edgar/data/1515673/000119312513435507/d601113dex42.htm) | &nbsp;&nbsp;S-1 | &nbsp;&nbsp;11/8/2013 | &nbsp;&nbsp;4.2 |  |
| &nbsp;&nbsp;4.4 | &nbsp;&nbsp;[<u>2014 Incentive Plan, as amended</u>](https://www.sec.gov/Archives/edgar/data/1515673/000156459017001714/rare-ex1020_605.htm) | &nbsp;&nbsp;10-K | &nbsp;&nbsp;2/17/2017 | &nbsp;&nbsp;10.20 |  |
| &nbsp;&nbsp;4.5 | &nbsp;&nbsp;[<u>2014 Employee Stock Purchase Plan, as amended</u>](https://www.sec.gov/Archives/edgar/data/1515673/000156459017001714/rare-ex1028_614.htm) | &nbsp;&nbsp;10-K | &nbsp;&nbsp;2/17/2017 | &nbsp;&nbsp;10.28 |  |
| &nbsp;&nbsp;5.1 | &nbsp;&nbsp;[<u>Opinion of Gibson, Dunn & Crutcher LLP</u>](rare-ex5_1.htm) |  |  |  | &nbsp;&nbsp;X |
| &nbsp;&nbsp;23.1 | &nbsp;&nbsp;[<u>Consent of Independent Registered Public Accounting Firm</u>](rare-ex23_1.htm) |  |  |  | &nbsp;&nbsp;X |
| &nbsp;&nbsp;23.2 | &nbsp;&nbsp;[<u>Consent of Gibson, Dunn & Crutcher LLP (included in Exhibit 5.1)</u>](rare-ex5_1.htm) |  |  |  | &nbsp;&nbsp;X |
| &nbsp;&nbsp;24.1 | &nbsp;&nbsp;[<u>Power of Attorney (included on the signature page to this Registration Statement)</u>](#power_of_attorney) |  |  |  | &nbsp;&nbsp;X |
| &nbsp;&nbsp;107.1 | &nbsp;&nbsp;[<u>Filing Fee Table</u>](rare-exfiling_fees.htm) |  |  |  | &nbsp;&nbsp;X |

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**SIGNATURES** 

Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Novato, State of California, on February 16, 2023.

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| | |
|:---|:---|
| ULTRAGENYX PHARMACEUTICAL INC. | ULTRAGENYX PHARMACEUTICAL INC. |
| By: | /s/ Emil D. Kakkis |
| Name: | Emil D. Kakkis, M.D., Ph.D. |
| Title: | President and Chief Executive Officer |

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**POWER OF ATTORNEY**

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints each of Emil D. Kakkis, M.D., Ph.D. and Theodore A. Huizenga and each of them acting individually, as his or her true and lawful attorneys-in-fact and agents, each with full power of substitution and resubstitution in each of them singly, for him or her and in his or her name, place and stead, and in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting to the attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite or necessary to be done in or about the premises, as full to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that the attorneys-in-fact and agents or any of each of them or their substitutes may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities indicated on the dates indicated.

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| | | |
|:---|:---|:---|
| &nbsp;&nbsp;<u>Signature</u> | &nbsp;&nbsp;<u>Title</u> | &nbsp;&nbsp;Date |
| &nbsp;&nbsp;&nbsp;&nbsp; <br>/s/ Emil D. Kakkis<br> Emil D. Kakkis, M.D., Ph.D. | &nbsp;&nbsp; <br>Director, President and Chief Executive Officer<br>(Principal Executive Officer and Principal Financial Officer) | &nbsp;&nbsp;February 16, 2023 |
| &nbsp;&nbsp;&nbsp;&nbsp; <br>/s/ Theodore A. Huizenga<br> Theodore A. Huizenga | &nbsp;&nbsp; <br>Senior Vice President and Chief Accounting Officer<br>(Principal Accounting Officer) | &nbsp;&nbsp;February 16, 2023 |
| &nbsp;&nbsp;&nbsp;&nbsp; <br>/s/ Daniel G. Welch<br> Daniel G. Welch | &nbsp;&nbsp;Chairman of the Board | &nbsp;&nbsp;February 16, 2023 |
| &nbsp;&nbsp;&nbsp;&nbsp; <br>/s/ Deborah Dunsire<br>Deborah Dunsire, M.D. | &nbsp;&nbsp;Director | &nbsp;&nbsp;February 16, 2023 |
| &nbsp;&nbsp;&nbsp;&nbsp; <br>/s/ Lars Ekman<br>Lars Ekman, M.D., Ph.D. | &nbsp;&nbsp;Director | &nbsp;&nbsp;February 16, 2023 |
| &nbsp;&nbsp;&nbsp;&nbsp; <br>/s/ Matthew K. Fust<br> Matthew K. Fust | &nbsp;&nbsp;Director | &nbsp;&nbsp;February 16, 2023 |
| &nbsp;&nbsp;&nbsp;&nbsp; <br>/s/ Michael Narachi<br> Michael Narachi | &nbsp;&nbsp;Director | &nbsp;&nbsp;February 16, 2023 |
| &nbsp;&nbsp;&nbsp;&nbsp; <br>/s/ Amrit Ray, M.D.<br> Amrit Ray, M.D. | &nbsp;&nbsp;Director | &nbsp;&nbsp;February 16, 2023 |
| &nbsp;&nbsp;&nbsp;&nbsp; <br>/s/ Corsee D. Sanders<br> Corsee D. Sanders, Ph.D. | &nbsp;&nbsp;Director | &nbsp;&nbsp;February 16, 2023 |
| &nbsp;&nbsp;&nbsp;&nbsp; <br>/s/ Shehnaaz Suliman<br> Shehnaaz Suliman, M.D. | &nbsp;&nbsp;Director | &nbsp;&nbsp;February 16, 2023 |

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## Ex-5

Gibson, Dunn & Crutcher LLP

Gibson, Dunn & Crutcher LLP

2029 Century Park East<br>Los Angeles, CA 90067-3025

Tel 310.552.8500

www.gibsondunn.com

Abu Dhabi  Beijing  Brussels  Century City  Dallas  Denver  Dubai  Frankfurt  Hong Kong  Houston  London  Los Angeles<br>Munich  New York  Orange County  Palo Alto  Paris  San Francisco  Singapore  Washington, D.C.

![img163890588_0.jpg](img163890588_0.jpg)

**Exhibit 5.1**

February 16, 2023

Ultragenyx Pharmaceutical Inc.<br>60 Leveroni Court<br>Novato, CA 94949

Re: Ultragenyx Pharmaceutical Inc.<br> Registration Statement on Form S-8

Ladies and Gentlemen:

We have examined the Registration Statement on Form S-8 (the "<u>Registration Statement</u>"), of Ultragenyx Pharmaceutical Inc., a Delaware corporation (the "<u>Company</u>") filed with the Securities and Exchange Commission (the "<u>Commission</u>") pursuant to the Securities Act of 1933, as amended (the "<u>Securities Act</u>"), in connection with the offering by the Company of up to (a) 2,500,000 shares of the Company's common stock, par value $0.001 per share (the "<u>Common Stock</u>"), issuable to eligible individuals under the Company's 2014 Incentive Plan (as amended, the "<u>2014 Plan</u>") and (b) 819,336 shares of Common Stock issuable to eligible individuals under the Company's 2014 Employee Stock Purchase Plan (as amended, the "<u>ESPP</u>" and together with the 2014 Plan, the "<u>Plans</u>").

We have examined the Plans and the originals, or photostatic or certified copies, of such records of the Company and certificates of officers of the Company and of public officials and such other documents as we have deemed relevant and necessary as the basis for the opinions set forth below. We have also made such other investigations as we have deemed relevant and necessary or appropriate in connection with the opinion hereinafter set forth. In our examination, we have assumed the genuineness of all signatures, the legal capacity and competency of all natural persons, the authenticity of all documents submitted to us as originals and the conformity to original documents of all documents submitted to us as copies. We have also assumed that there are no agreements or understandings between or among the Company and any participants in the Plans that would expand, modify or otherwise affect the terms of the Plans or the respective rights or obligations of the participants thereunder. Finally, we have assumed the accuracy of all other information provided to us by the Company during the course of our investigations, on which we have relied in issuing the opinion expressed below.

Based upon the foregoing examination and in reliance thereon, and subject to the assumptions stated and in reliance on statements of fact contained in the documents that we have examined, we are of the opinion that the shares of Common Stock issuable under the Plans, when issued and sold in accordance with the terms of the respective Plans and against payment therefor, and when the Registration Statement has become effective under the Securities Act, will be validly issued, fully paid and non-assessable.

We render no opinion herein as to matters involving the laws of any jurisdiction other than the Delaware General Corporation Law (the "<u>DGCL</u>"). We are not admitted to practice in the State of Delaware; however, we are generally familiar with the DGCL as currently in effect and have made such inquiries as we

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<br>Ultragenyx Pharmaceutical Inc.

February 16, 2023

![img163890588_1.jpg](img163890588_1.jpg)

consider necessary to render the opinions above. This opinion is limited to the effect of the current state of the law of the DGCL and the facts as they currently exist. We assume no obligation to revise or supplement this opinion in the event of future changes in such law or the interpretations thereof or such facts.

We consent to the filing of this opinion as an exhibit to the Registration Statement. In giving this consent, we do not thereby admit that we are within the category of persons whose consent is required under Section 7 of the Securities Act or the Rules and Regulations of the Commission.

Very truly yours,<br>/s/ Gibson, Dunn & Crutcher LLP<br>Gibson, Dunn & Crutcher LLP<br>

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## Ex-23

**Exhibit 23.1**

**CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM**

We consent to the incorporation by reference in the Registration Statement (Form S-8) pertaining to the 2014 Incentive Plan and the 2014 Employee Stock Purchase Plan of Ultragenyx Pharmaceutical Inc. of our reports dated February 16, 2023, with respect to the consolidated financial statements of Ultragenyx Pharmaceutical Inc. and the effectiveness of internal control over financial reporting of Ultragenyx Pharmaceutical Inc. included in its Annual Report (Form 10-K) for the year ended December 31, 2022, filed with the Securities and Exchange Commission.

/s/ Ernst & Young LLP

San Mateo, California

February 16, 2023

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## Ex-Filing

**Exhibit 107.1**

**Calculation of Filing Fee Tables**

**FORM S-8**

(Form Type)

**ULTRAGENYX PHARMACEUTICAL INC.**

(Exact Name of Registrant as Specified in its Charter)

<u>Table 1: Newly Registered Securities</u> ****

<br> ---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;**Security Type** | **Security Class Title (1)** | **Fee Calculation Rule**  | &nbsp;&nbsp;**Amount Registered** | **Proposed Maximum<br>Offering Price Per Unit** | **Maximum<br>Aggregate<br>Offering Price** | &nbsp;&nbsp;**Fee Rate** | **Amount of<br>Registration Fee** |
| &nbsp;&nbsp;Equity | Common stock, $0.001 par value per share | Rule 457(c) and <br>Rule 457(h) (2) | &nbsp;&nbsp;2500000 (3) | $44.28 | $110700000.00 | &nbsp;&nbsp;$110.20 per $1,000,000 | $12199.14 |
| &nbsp;&nbsp;Equity | Common stock, $0.001 par value per share | Rule 457(c) and <br>Rule 457(h) (4) | &nbsp;&nbsp;819336 (5) | $37.64 | $30839807.04 | &nbsp;&nbsp;$110.20 per $1,000,000 | $3398.55 |
| &nbsp;&nbsp;**Total Offering Amounts** | &nbsp;&nbsp;**Total Offering Amounts** | &nbsp;&nbsp;**Total Offering Amounts** | &nbsp;&nbsp;**Total Offering Amounts** |  | $141539807.04 |  | $15597.69 |
| &nbsp;&nbsp;**Total Fee Offsets** | &nbsp;&nbsp;**Total Fee Offsets** | &nbsp;&nbsp;**Total Fee Offsets** | &nbsp;&nbsp;**Total Fee Offsets** |  |  |  |  |
| &nbsp;&nbsp;**Net Fee Due** | &nbsp;&nbsp;**Net Fee Due** | &nbsp;&nbsp;**Net Fee Due** | &nbsp;&nbsp;**Net Fee Due** |  |  |  | $15597.69 |

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement on Form S-8 (this "Registration Statement") shall also cover any additional shares of common stock, par value $0.001 per share (the "Common Stock") of Ultragenyx Pharmaceutical Inc. (the "Registrant") that become issuable under the Ultragenyx Pharmaceutical Inc. 2014 Incentive Plan (as amended, the "2014 Plan") and the Ultragenyx Pharmaceutical Inc. 2014 Employee Stock Purchase Plan (as amended, the "ESPP").

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and (h) of the Securities Act, and based on the average of the high and low sale prices of the Common Stock, as quoted on The Nasdaq Global Select Market, on February 10, 2023.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3) Represents 2,500,000 shares of Common Stock reserved for issuance under the 2014 Plan.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(4) Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and (h) of the Securities Act, and based on 85% of the average of the high and low sale prices of the Common Stock, as quoted on The Nasdaq Global Select Market, on February 10, 2023. Pursuant to the ESPP, the purchase price of a share of Common Stock is 85% of the fair market value of the Common Stock.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(5) Represents 819,336 shares of Common Stock reserved for issuance under the ESPP.

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