# EDGAR Filing Document

**Accession Number:** 0001892134
**File Stem:** 0001892134-26-000002
**Filing Date:** 2026-5
**Character Count:** 7837
**Document Hash:** fb28c1a2c89dae4a5635bb43765331d8
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001892134-26-000002.hdr.sgml**: 20260515

**ACCESSION NUMBER**: 0001892134-26-000002

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20260331

**FILED AS OF DATE**: 20260515

**DATE AS OF CHANGE**: 20260515

**EFFECTIVENESS DATE**: 20260515

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Frazier Life Sciences Management, L.P.
- **CENTRAL INDEX KEY:** 0001892134

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-22504
- **FILM NUMBER:** 26985572

**BUSINESS ADDRESS:**
- **STREET 1:** 1001 PAGE MILL ROAD
- **STREET 2:** BUILDING 4, SUITE 200B
- **CITY:** PALO ALTO
- **STATE:** CA
- **ZIP:** 94304
- **BUSINESS PHONE:** (650) 325-5156

**MAIL ADDRESS:**
- **STREET 1:** 1001 PAGE MILL ROAD
- **STREET 2:** BUILDING 4, SUITE 200B
- **CITY:** PALO ALTO
- **STATE:** CA
- **ZIP:** 94304

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 03-31-2026

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** Frazier Life Sciences Management L.P.<br>**Address:** 1001 PAGE MILL ROAD<br>BUILDING 4 SUITE 200B<br>PALO ALTO, CA 94304

**Form 13F File Number:** 028-22504

**CRD Number (if applicable):** 000317522

**SEC File Number (if applicable):** 801-122904

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Jennifer Martin<br>**Title:** Chief Financial Officer<br>**Phone:** 2062541108

**Signature, Place, and Date of Signing:**

Jennifer Martin  Seattle, WA  05-15-2026<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 38

**Form 13F Information Table Value Total:** $3886526658

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 |  | 32014287 | 1438198 | SH |  | SOLE |  | 1438198 | 0 | 0 |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 |  | 18470153 | 4925374 | SH |  | SOLE |  | 4925374 | 0 | 0 |
| AGIOS PHARMACEUTICALS INC | COM | 00847X104 |  | 42493186 | 1256080 | SH |  | SOLE |  | 1256080 | 0 | 0 |
| ALKERMES PLC | SHS | G01767105 |  | 24774878 | 700647 | SH |  | SOLE |  | 700647 | 0 | 0 |
| ALLOGENE THERAPEUTICS INC | COM | 019770106 |  | 9263870 | 3796668 | SH |  | SOLE |  | 3796668 | 0 | 0 |
| ARCUTIS BIOTHERAPEUTICS INC | COM | 03969K108 |  | 232643479 | 9874511 | SH |  | SOLE |  | 9874511 | 0 | 0 |
| ASCENDIS PHARMA A/S | SPONSORED ADR | 04351P101 |  | 30497257 | 133333 | SH |  | SOLE |  | 133333 | 0 | 0 |
| AURA BIOSCIENCES INC | COM | 05153U107 |  | 34119000 | 5100000 | SH |  | SOLE |  | 5100000 | 0 | 0 |
| AUTOLUS THERAPEUTICS LTD | SPON ADS | 05280R100 |  | 6138116 | 4447910 | SH |  | SOLE |  | 4447910 | 0 | 0 |
| BIOCRYST PHARMACEUTICALS INC | COM | 09058V103 |  | 38167965 | 4009240 | SH |  | SOLE |  | 4009240 | 0 | 0 |
| BRIDGEBIO PHARMA INC | COM | 10806X102 |  | 256058802 | 3448139 | SH |  | SOLE |  | 3448139 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 76447625 | 1159879 | SH |  | SOLE |  | 1159879 | 0 | 0 |
| DISC MEDICINE INC | COM | 254604101 |  | 86629237 | 1354852 | SH |  | SOLE |  | 1354852 | 0 | 0 |
| DYNE THERAPEUTICS INC | COM | 26818M108 |  | 57165377 | 3153082 | SH |  | SOLE |  | 3153082 | 0 | 0 |
| ERASCA INC | COM | 29479A108 |  | 399244542 | 24675188 | SH |  | SOLE |  | 24675188 | 0 | 0 |
| EVOLUS INC | COM | 30052C107 |  | 10812033 | 2630665 | SH |  | SOLE |  | 2630665 | 0 | 0 |
| IBIO INC | COM NEW | 451033708 |  | 3711587 | 1953467 | SH |  | SOLE |  | 1953467 | 0 | 0 |
| IMMUNOCORE HLDGS PLC | ADS | 45258D105 |  | 14616177 | 484782 | SH |  | SOLE |  | 484782 | 0 | 0 |
| KALVISTA PHARMACEUTICALS INC | COM | 483497103 |  | 99867104 | 4961108 | SH |  | SOLE |  | 4961108 | 0 | 0 |
| KRYSTAL BIOTECH INC | COM | 501147102 |  | 124331224 | 481307 | SH |  | SOLE |  | 481307 | 0 | 0 |
| LEXEO THERAPEUTICS INC | COM | 52886X107 |  | 25397922 | 4424725 | SH |  | SOLE |  | 4424725 | 0 | 0 |
| MANNKIND CORP | COM NEW | 56400P706 |  | 14455000 | 5900000 | SH |  | SOLE |  | 5900000 | 0 | 0 |
| MAZE THERAPEUTICS INC | COM | 578784100 |  | 136333129 | 4567274 | SH |  | SOLE |  | 4567274 | 0 | 0 |
| MBX BIOSCIENCES INC | COM | 55287L101 |  | 198562588 | 6652013 | SH |  | SOLE |  | 6652013 | 0 | 0 |
| MIRUM PHARMACEUTICALS INC | COM | 604749101 |  | 709449208 | 7679684 | SH |  | SOLE |  | 7679684 | 0 | 0 |
| MONTE ROSA THERAPEUTICS INC | COM | 61225M102 |  | 16450000 | 1000000 | SH |  | SOLE |  | 1000000 | 0 | 0 |
| NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | N62509109 |  | 542370206 | 16943774 | SH |  | SOLE |  | 16943774 | 0 | 0 |
| NEWAMSTERDAM PHARMA COMPANY | *W EXP 99/99/999 | N62509117 |  | 10026673 | 500333 | SH |  | SOLE |  | 500333 | 0 | 0 |
| PALVELLA THERAPEUTICS INC NE | COM | 697947109 |  | 109991160 | 882400 | SH |  | SOLE |  | 882400 | 0 | 0 |
| PHATHOM PHARMACEUTICALS INC | COM | 71722W107 |  | 138502693 | 12466489 | SH |  | SOLE |  | 12466489 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 65710464 | 675686 | SH |  | SOLE |  | 675686 | 0 | 0 |
| SAVARA INC | COM | 805111101 |  | 53075852 | 9720852 | SH |  | SOLE |  | 9720852 | 0 | 0 |
| TARSUS PHARMACEUTICALS INC | COM | 87650L103 |  | 51114377 | 728644 | SH |  | SOLE |  | 728644 | 0 | 0 |
| TREVI THERAPEUTICS INC | COM | 89532M101 |  | 118578796 | 9939547 | SH |  | SOLE |  | 9939547 | 0 | 0 |
| VALNEVA SE | SPONSORED ADS | 92025Y103 |  | 14322913 | 2291666 | SH |  | SOLE |  | 2291666 | 0 | 0 |
| VOR BIOPHARMA INC | COM NEW | 929033207 |  | 45383872 | 2543939 | SH |  | SOLE |  | 2543939 | 0 | 0 |
| XILIO THERAPEUTICS INC | COM | 98422T209 |  | 3553267 | 422505 | SH |  | SOLE |  | 422505 | 0 | 0 |
| ZAI LAB LTD | ADR | 98887Q104 |  | 35782639 | 1902320 | SH |  | SOLE |  | 1902320 | 0 | 0 |

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