# EDGAR Filing Document

**Accession Number:** 0001064642
**File Stem:** 0001752724-23-046924
**Filing Date:** 2023-2
**Character Count:** 60050
**Document Hash:** ab5db3f72d9d6296fba0913a83266936
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001752724-23-046924.hdr.sgml**: 20230228

**ACCESSION NUMBER**: 0001752724-23-046924

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230228

**DATE AS OF CHANGE**: 20230228

**PERIOD START**: 20230630

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** SPDR SERIES TRUST
- **CENTRAL INDEX KEY:** 0001064642
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** MA

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-08839
- **FILM NUMBER:** 23683544

**BUSINESS ADDRESS:**
- **STREET 1:** ONE LINCOLN STREET
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02111
- **BUSINESS PHONE:** 617-664-1465

**MAIL ADDRESS:**
- **STREET 1:** ONE LINCOLN STREET
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02111

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** STREETTRACKS SERIES TRUST
- **DATE OF NAME CHANGE:** 20000925

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** INDEX EXCHANGE LISTED SECURITIES TRUST
- **DATE OF NAME CHANGE:** 19980622

## Series and Classes Contracts Data

### SPDR(R) S&P(R) Biotech ETF (Series ID: S000010018)

| Class ID   | Class Name                 | Ticker Symbol   |
|:---|:---|:---|
| C000027706 | SPDR(R) S&P(R) Biotech ETF | XBI             |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** SPDR SERIES TRUST

- **b. Investment Company Act file number:** 811-08839

- **c. CIK number of Registrant:** 0001064642

- **d. LEI of Registrant:** 5493004JVD6CQEEJSS37

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** One Iron Street

  - **City:** Boston

  - **State:** MA

  - **Foreign country:** US

  - **Zip / Postal Code:** 02210

  - **Telephone number:** 617-664-8594

**Item A.2. Information about the Series.**

- **a. Name of Series:** SPDR(R) S&P(R) Biotech ETF

- **b. EDGAR series identifier (if any):** S000010018

- **c. LEI of Series:** 549300Y3ODFMPD5XXL58

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2023-06-30

- **b. Date as of which information is reported:** 2022-12-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $8783230163.98

**Total Liabilities:** $693488302.16

**Net Assets:** $8089741861.82

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000027706 | 3.50%                | 1.96%                | -0.83%               |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $124132756.64            | $119011699.42                              |
| Month 2  | $84323275.10             | $44269086.56                               |
| Month 3  | $-283489217.54           | $201592019.31                              |

### Schedule of Portfolio Investments

| Name                               | Title                                                                       | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Ionis Pharmaceuticals Inc          | Ionis Pharmaceuticals Inc                                                   | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |   2077263 | NS      | $78458223.51  | 0.97%             |  |  |  | No            |                  1 | On Loan: No      |
| MiMedx Group Inc                   | MiMedx Group Inc                                                            | CUSIP: 602496101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1705751 | NS      | $4741987.78   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| 2seventy bio Inc                   | 2seventy bio Inc                                                            | CUSIP: 901384107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1272464 | NS      | $11922987.68  | 0.15%             |  |  |  | No            |                  1 | On Loan: —       |
| Arrowhead Pharmaceuticals Inc      | Arrowhead Pharmaceuticals Inc                                               | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |   2575870 | NS      | $104477287.20 | 1.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Protagonist Therapeutics Inc       | Protagonist Therapeutics Inc                                                | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2852984 | NS      | $31126055.44  | 0.38%             |  |  |  | No            |                  1 | On Loan: No      |
| Rhythm Pharmaceuticals Inc         | Rhythm Pharmaceuticals Inc                                                  | CUSIP: 76243J105<br>LEI: 529900JPNWXQ8DPLA551 | Long             | EC               | CORP              | US        |   2957461 | NS      | $86121264.32  | 1.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Alnylam Pharmaceuticals Inc        | Alnylam Pharmaceuticals Inc                                                 | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |    336825 | NS      | $80046461.25  | 0.99%             |  |  |  | No            |                  1 | On Loan: No      |
| Kezar Life Sciences Inc            | Kezar Life Sciences Inc                                                     | CUSIP: 49372L100<br>LEI: 549300EV1V8GXBV18004 | Long             | EC               | CORP              | US        |   3367391 | NS      | $23706432.64  | 0.29%             |  |  |  | No            |                  1 | On Loan: —       |
| Anavex Life Sciences Corp          | Anavex Life Sciences Corp                                                   | CUSIP: 032797300<br>LEI: 549300K1I5L8COCQ8W36 | Long             | EC               | CORP              | US        |   4488131 | NS      | $41560093.06  | 0.51%             |  |  |  | No            |                  1 | On Loan: —       |
| Relay Therapeutics Inc             | Relay Therapeutics Inc                                                      | CUSIP: 75943R102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   4580079 | NS      | $68426380.26  | 0.85%             |  |  |  | No            |                  1 | On Loan: —       |
| Kura Oncology Inc                  | Kura Oncology Inc                                                           | CUSIP: 50127T109<br>LEI: 5493005QORQTZCZYOP39 | Long             | EC               | CORP              | US        |   3164647 | NS      | $39273269.27  | 0.49%             |  |  |  | No            |                  1 | On Loan: —       |
| Vertex Pharmaceuticals Inc         | Vertex Pharmaceuticals Inc                                                  | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |    249527 | NS      | $72058407.06  | 0.89%             |  |  |  | No            |                  1 | On Loan: No      |
| BioCryst Pharmaceuticals Inc       | BioCryst Pharmaceuticals Inc                                                | CUSIP: 09058V103<br>LEI: 549300Z0INP1Z5NP6J59 | Long             | EC               | CORP              | US        |   7418288 | NS      | $85161946.24  | 1.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Exact Sciences Corp                | Exact Sciences Corp                                                         | CUSIP: 30063P105<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |   1746585 | NS      | $86473423.35  | 1.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Intercept Pharmaceuticals Inc      | Intercept Pharmaceuticals Inc                                               | CUSIP: 45845P108<br>LEI: 254900JMB8TX5P688V24 | Long             | EC               | CORP              | US        |   2567453 | NS      | $31759393.61  | 0.39%             |  |  |  | No            |                  1 | On Loan: —       |
| Caribou Biosciences Inc            | Caribou Biosciences Inc                                                     | CUSIP: 142038108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2040202 | NS      | $12812468.56  | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Verve Therapeutics Inc             | Verve Therapeutics Inc                                                      | CUSIP: 92539P101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   3597798 | NS      | $69617391.30  | 0.86%             |  |  |  | No            |                  1 | On Loan: —       |
| Keros Therapeutics Inc             | Keros Therapeutics Inc                                                      | CUSIP: 492327101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    636653 | NS      | $30572077.06  | 0.38%             |  |  |  | No            |                  1 | On Loan: No      |
| Anika Therapeutics Inc             | Anika Therapeutics Inc                                                      | CUSIP: 035255108<br>LEI: 529900R9LS3Z0O6QH455 | Long             | EC               | CORP              | US        |    270453 | NS      | $8005408.80   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Adicet Bio Inc                     | Adicet Bio Inc                                                              | CUSIP: 007002108<br>LEI: 549300VRD2QO80WBOP18 | Long             | EC               | CORP              | US        |   1758040 | NS      | $15716877.60  | 0.19%             |  |  |  | No            |                  1 | On Loan: —       |
| Catalyst Pharmaceuticals Inc       | Catalyst Pharmaceuticals Inc                                                | CUSIP: 14888U101<br>LEI: 5299004O0R5XXLA5H544 | Long             | EC               | CORP              | US        |   4755330 | NS      | $88449138.00  | 1.09%             |  |  |  | No            |                  1 | On Loan: —       |
| AbbVie Inc                         | AbbVie Inc                                                                  | CUSIP: 00287Y109<br>LEI: FR5LCKFTG8054YNNRU85 | Long             | EC               | CORP              | US        |    477609 | NS      | $77186390.49  | 0.95%             |  |  |  | No            |                  1 | On Loan: No      |
| Ocugen Inc                         | Ocugen Inc                                                                  | CUSIP: 67577C105<br>LEI: 549300JVNUI9CXWJLR09 | Long             | EC               | CORP              | US        |  23864671 | NS      | $31024072.30  | 0.38%             |  |  |  | No            |                  1 | On Loan: —       |
| Prometheus Biosciences Inc         | Prometheus Biosciences Inc                                                  | CUSIP: 74349U108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    706904 | NS      | $77759440.00  | 0.96%             |  |  |  | No            |                  1 | On Loan: No      |
| Myriad Genetics Inc                | Myriad Genetics Inc                                                         | CUSIP: 62855J104<br>LEI: 52990044IHUOUMETT163 | Long             | EC               | CORP              | US        |   1994201 | NS      | $28935856.51  | 0.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Lyell Immunopharma Inc             | Lyell Immunopharma Inc                                                      | CUSIP: 55083R104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   5612855 | NS      | $19476606.85  | 0.24%             |  |  |  | No            |                  1 | On Loan: —       |
| PMV Pharmaceuticals Inc            | PMV Pharmaceuticals Inc                                                     | CUSIP: 69353Y103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2558483 | NS      | $22258802.10  | 0.28%             |  |  |  | No            |                  1 | On Loan: —       |
| Avid Bioservices Inc               | Avid Bioservices Inc                                                        | CUSIP: 05368M106<br>LEI: 549300GRUS3ZMGP8MX22 | Long             | EC               | CORP              | US        |   3087934 | NS      | $42520851.18  | 0.53%             |  |  |  | No            |                  1 | On Loan: —       |
| Chinook Therapeutics Inc           | Chinook Therapeutics Inc                                                    | CUSIP: 16961L106<br>LEI: 549300X0O3003W5QYQ48 | Long             | EC               | CORP              | US        |   1680101 | NS      | $44018646.20  | 0.54%             |  |  |  | No            |                  1 | On Loan: No      |
| BioMarin Pharmaceutical Inc        | BioMarin Pharmaceutical Inc                                                 | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |    761288 | NS      | $78785695.12  | 0.97%             |  |  |  | No            |                  1 | On Loan: No      |
| Geron Corp                         | Geron Corp                                                                  | CUSIP: 374163103<br>LEI: 549300T282D7Z2YESL90 | Long             | EC               | CORP              | US        |  12362095 | NS      | $29916269.90  | 0.37%             |  |  |  | No            |                  1 | On Loan: —       |
| Eagle Pharmaceuticals Inc/DE       | Eagle Pharmaceuticals Inc/DE                                                | CUSIP: 269796108<br>LEI: 549300TN20OLYTJVP152 | Long             | EC               | CORP              | US        |    567689 | NS      | $16593549.47  | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Viridian Therapeutics Inc          | Viridian Therapeutics Inc                                                   | CUSIP: 92790C104<br>LEI: 549300C775BNYF550E70 | Long             | EC               | CORP              | US        |   1130720 | NS      | $33028331.20  | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Sage Therapeutics Inc              | Sage Therapeutics Inc                                                       | CUSIP: 78667J108<br>LEI: 5493000JX4BJS9W6CN35 | Long             | EC               | CORP              | US        |   1582610 | NS      | $60360745.40  | 0.75%             |  |  |  | No            |                  1 | On Loan: No      |
| OMNIAB INC                         | OMNIAB INC                                                                  | CUSIP: 68218J301<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    161960 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  3 | On Loan: —       |
| Beam Therapeutics Inc              | Beam Therapeutics Inc                                                       | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1849303 | NS      | $72326240.33  | 0.89%             |  |  |  | No            |                  1 | On Loan: —       |
| Seres Therapeutics Inc             | Seres Therapeutics Inc                                                      | CUSIP: 81750R102<br>LEI: 549300GMXBE5NUWISF13 | Long             | EC               | CORP              | US        |   3064231 | NS      | $17159693.60  | 0.21%             |  |  |  | No            |                  1 | On Loan: —       |
| Travere Therapeutics Inc           | Travere Therapeutics Inc                                                    | CUSIP: 89422G107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   3086858 | NS      | $64916623.74  | 0.80%             |  |  |  | No            |                  1 | On Loan: —       |
| Erasca Inc                         | Erasca Inc                                                                  | CUSIP: 29479A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2764242 | NS      | $11913883.02  | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Vanda Pharmaceuticals Inc          | Vanda Pharmaceuticals Inc                                                   | CUSIP: 921659108<br>LEI: 529900AY8VOOQBKJ0O70 | Long             | EC               | CORP              | US        |   1353374 | NS      | $10001433.86  | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| AnaptysBio Inc                     | AnaptysBio Inc                                                              | CUSIP: 032724106<br>LEI: 529900HH4WQT03IG1A12 | Long             | EC               | CORP              | US        |    678122 | NS      | $21015000.78  | 0.26%             |  |  |  | No            |                  1 | On Loan: —       |
| Horizon Therapeutics Plc           | Horizon Therapeutics Plc                                                    | CUSIP: 000000000<br>LEI: 529900P0GSQ79OOZEV53 | Long             | EC               | CORP              | IE        |    800574 | NS      | $91105321.20  | 1.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Seagen Inc                         | Seagen Inc                                                                  | CUSIP: 81181C104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    628242 | NS      | $80735379.42  | 1.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Alector Inc                        | Alector Inc                                                                 | CUSIP: 014442107<br>LEI: 549300Z8RQOIY1JMHC25 | Long             | EC               | CORP              | US        |   2007112 | NS      | $18525643.76  | 0.23%             |  |  |  | No            |                  1 | On Loan: —       |
| Agios Pharmaceuticals Inc          | Agios Pharmaceuticals Inc                                                   | CUSIP: 00847X104<br>LEI: 529900ONJHY8EOGYT555 | Long             | EC               | CORP              | US        |   2044679 | NS      | $57414586.32  | 0.71%             |  |  |  | No            |                  1 | On Loan: —       |
| Arcturus Therapeutics Holdings Inc | Arcturus Therapeutics Holdings Inc                                          | CUSIP: 03969T109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1499769 | NS      | $25436082.24  | 0.31%             |  |  |  | No            |                  1 | On Loan: —       |
| Intellia Therapeutics Inc          | Intellia Therapeutics Inc                                                   | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |   2053059 | NS      | $71631228.51  | 0.89%             |  |  |  | No            |                  1 | On Loan: —       |
| Point Biopharma Global Inc         | Point Biopharma Global Inc                                                  | CUSIP: 730541109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2871387 | NS      | $20932411.23  | 0.26%             |  |  |  | No            |                  1 | On Loan: —       |
| Halozyme Therapeutics Inc          | Halozyme Therapeutics Inc                                                   | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |   1368341 | NS      | $77858602.90  | 0.96%             |  |  |  | No            |                  1 | On Loan: No      |
| Bluebird Bio Inc                   | Bluebird Bio Inc                                                            | CUSIP: 09609G100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |  10399636 | NS      | $71965481.12  | 0.89%             |  |  |  | No            |                  1 | On Loan: —       |
| Apellis Pharmaceuticals Inc        | Apellis Pharmaceuticals Inc                                                 | CUSIP: 03753U106<br>LEI: 254900HS0ZFRXXSB9D42 | Long             | EC               | CORP              | US        |   1585472 | NS      | $81984757.12  | 1.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen Inc                         | Biogen Inc                                                                  | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |    273017 | NS      | $75603867.64  | 0.93%             |  |  |  | No            |                  1 | On Loan: No      |
| Madrigal Pharmaceuticals Inc       | Madrigal Pharmaceuticals Inc                                                | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |   1019327 | NS      | $295859661.75 | 3.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Ironwood Pharmaceuticals Inc       | Ironwood Pharmaceuticals Inc                                                | CUSIP: 46333X108<br>LEI: 549300PC8MR6QHH6P296 | Long             | EC               | CORP              | US        |   6575810 | NS      | $81474285.90  | 1.01%             |  |  |  | No            |                  1 | On Loan: —       |
| United Therapeutics Corp           | United Therapeutics Corp                                                    | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |    277818 | NS      | $77258407.62  | 0.96%             |  |  |  | No            |                  1 | On Loan: No      |
| ACADIA Pharmaceuticals Inc         | ACADIA Pharmaceuticals Inc                                                  | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |   5375669 | NS      | $85580650.48  | 1.06%             |  |  |  | No            |                  1 | On Loan: —       |
| CTI BioPharma Corp                 | CTI BioPharma Corp                                                          | CUSIP: 12648L601<br>LEI: N/A                  | Long             | EC               | CORP              | US        |  14208742 | NS      | $85394539.42  | 1.06%             |  |  |  | No            |                  1 | On Loan: No      |
| REVOLUTION Medicines Inc           | REVOLUTION Medicines Inc                                                    | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |   2292490 | NS      | $54607111.80  | 0.68%             |  |  |  | No            |                  1 | On Loan: —       |
| Moderna Inc                        | Moderna Inc                                                                 | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |    439155 | NS      | $78881021.10  | 0.98%             |  |  |  | No            |                  1 | On Loan: No      |
| Biohaven Ltd                       | Biohaven Ltd                                                                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | VG        |   3478804 | NS      | $48285799.52  | 0.60%             |  |  |  | No            |                  1 | On Loan: No      |
| Iovance Biotherapeutics Inc        | Iovance Biotherapeutics Inc                                                 | CUSIP: 462260100<br>LEI: 549300220Z2GHH33XL82 | Long             | EC               | CORP              | US        |  11256263 | NS      | $71927520.57  | 0.89%             |  |  |  | No            |                  1 | On Loan: No      |
| Mersana Therapeutics Inc           | Mersana Therapeutics Inc                                                    | CUSIP: 59045L106<br>LEI: 529900VWD5VDZ7PVOS22 | Long             | EC               | CORP              | US        |   4025521 | NS      | $23589553.06  | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Recursion Pharmaceuticals Inc      | Recursion Pharmaceuticals Inc                                               | CUSIP: 75629V104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   5048755 | NS      | $38925901.05  | 0.48%             |  |  |  | No            |                  1 | On Loan: —       |
| Celldex Therapeutics Inc           | Celldex Therapeutics Inc                                                    | CUSIP: 15117B202<br>LEI: 529900F018DMYWH38923 | Long             | EC               | CORP              | US        |   1384193 | NS      | $61693482.01  | 0.76%             |  |  |  | No            |                  1 | On Loan: —       |
| ImmunoGen Inc                      | ImmunoGen Inc                                                               | CUSIP: 45253H101<br>LEI: 54930084U0R1OP766Y02 | Long             | EC               | CORP              | US        |  13214234 | NS      | $65542600.64  | 0.81%             |  |  |  | No            |                  1 | On Loan: No      |
| Twist Bioscience Corp              | Twist Bioscience Corp                                                       | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |   3189755 | NS      | $75948066.55  | 0.94%             |  |  |  | No            |                  1 | On Loan: —       |
| CRISPR Therapeutics AG             | CRISPR Therapeutics AG                                                      | CUSIP: 000000000<br>LEI: 506700O6IRRIQLT3W370 | Long             | EC               | CORP              | CH        |   1590048 | NS      | $64635451.20  | 0.80%             |  |  |  | No            |                  1 | On Loan: —       |
| Enanta Pharmaceuticals Inc         | Enanta Pharmaceuticals Inc                                                  | CUSIP: 29251M106<br>LEI: 529900SSN4DODDQSN594 | Long             | EC               | CORP              | US        |    805130 | NS      | $37454647.60  | 0.46%             |  |  |  | No            |                  1 | On Loan: No      |
| Denali Therapeutics Inc            | Denali Therapeutics Inc                                                     | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |   2738727 | NS      | $76163997.87  | 0.94%             |  |  |  | No            |                  1 | On Loan: No      |
| Sutro Biopharma Inc                | Sutro Biopharma Inc                                                         | CUSIP: 869367102<br>LEI: 5493005U6P15VD25P851 | Long             | EC               | CORP              | US        |    953146 | NS      | $7701419.68   | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| Kiniksa Pharmaceuticals Ltd        | Kiniksa Pharmaceuticals Ltd                                                 | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | BM        |    881704 | NS      | $13207925.92  | 0.16%             |  |  |  | No            |                  1 | On Loan: —       |
| Mirati Therapeutics Inc            | Mirati Therapeutics Inc                                                     | CUSIP: 60468T105<br>LEI: 529900GYRW59IDQV6N54 | Long             | EC               | CORP              | US        |   1865734 | NS      | $84536407.54  | 1.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Sana Biotechnology Inc             | Sana Biotechnology Inc                                                      | CUSIP: 799566104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   4943322 | NS      | $19526121.90  | 0.24%             |  |  |  | No            |                  1 | On Loan: —       |
| Myovant Sciences Ltd               | Myovant Sciences Ltd                                                        | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | BM        |   2674075 | NS      | $72093062.00  | 0.89%             |  |  |  | No            |                  1 | On Loan: No      |
| Akero Therapeutics Inc             | Akero Therapeutics Inc                                                      | CUSIP: 00973Y108<br>LEI: 549300SI3KG74LBE2955 | Long             | EC               | CORP              | US        |   1813524 | NS      | $99381115.20  | 1.23%             |  |  |  | No            |                  1 | On Loan: —       |
| Cerevel Therapeutics Holdings Inc  | Cerevel Therapeutics Holdings Inc                                           | CUSIP: 15678U128<br>LEI: 254900RJNIRS9COSQR41 | Long             | EC               | CORP              | US        |   2305133 | NS      | $72703894.82  | 0.90%             |  |  |  | No            |                  1 | On Loan: —       |
| Inovio Pharmaceuticals Inc         | Inovio Pharmaceuticals Inc                                                  | CUSIP: 45773H201<br>LEI: 529900B9W875XDZXTM97 | Long             | EC               | CORP              | US        |  25004842 | NS      | $39007553.52  | 0.48%             |  |  |  | No            |                  1 | On Loan: —       |
| ImmunityBio Inc                    | ImmunityBio Inc                                                             | CUSIP: 45256X103<br>LEI: 529900J9XLBR4HFL4B83 | Long             | EC               | CORP              | US        |   4552920 | NS      | $23083304.40  | 0.29%             |  |  |  | No            |                  1 | On Loan: —       |
| Incyte Corp                        | Incyte Corp                                                                 | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |    945965 | NS      | $75979908.80  | 0.94%             |  |  |  | No            |                  1 | On Loan: No      |
| Krystal Biotech Inc                | Krystal Biotech Inc                                                         | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |    594731 | NS      | $47114589.82  | 0.58%             |  |  |  | No            |                  1 | On Loan: —       |
| ADMA Biologics Inc                 | ADMA Biologics Inc                                                          | CUSIP: 000899104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   7634625 | NS      | $29622345.00  | 0.37%             |  |  |  | No            |                  1 | On Loan: —       |
| Fate Therapeutics Inc              | Fate Therapeutics Inc                                                       | CUSIP: 31189P102<br>LEI: 549300L14Q4UHOODLA90 | Long             | EC               | CORP              | US        |   4121385 | NS      | $41584774.65  | 0.51%             |  |  |  | No            |                  1 | On Loan: —       |
| State Street Global Advisors       | State Street Navigator Securities Lending Government Money Market Portfolio | CUSIP: 857492706<br>LEI: 5493008BJIBKQ5KTIF74 | Long             | STIV             | RF                | US        | 608792638 | NS      | $608792638.00 | 7.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Amgen Inc                          | Amgen Inc                                                                   | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |    279512 | NS      | $73411031.68  | 0.91%             |  |  |  | No            |                  1 | On Loan: No      |
| Ideaya Biosciences Inc             | Ideaya Biosciences Inc                                                      | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |   1489661 | NS      | $27067140.37  | 0.33%             |  |  |  | No            |                  1 | On Loan: —       |
| Karuna Therapeutics Inc            | Karuna Therapeutics Inc                                                     | CUSIP: 48576A100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    394914 | NS      | $77600601.00  | 0.96%             |  |  |  | No            |                  1 | On Loan: No      |
| Avidity Biosciences Inc            | Avidity Biosciences Inc                                                     | CUSIP: 05370A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2323043 | NS      | $51548324.17  | 0.64%             |  |  |  | No            |                  1 | On Loan: —       |
| Allakos Inc                        | Allakos Inc                                                                 | CUSIP: 01671P100<br>LEI: 549300S6ZD1W6BPMDY37 | Long             | EC               | CORP              | US        |   3162324 | NS      | $26626768.08  | 0.33%             |  |  |  | No            |                  1 | On Loan: —       |
| Replimune Group Inc                | Replimune Group Inc                                                         | CUSIP: 76029N106<br>LEI: 549300AY704NEIRC4K64 | Long             | EC               | CORP              | US        |    722263 | NS      | $19645553.60  | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Veracyte Inc                       | Veracyte Inc                                                                | CUSIP: 92337F107<br>LEI: 529900ESWZRHXOW27Z37 | Long             | EC               | CORP              | US        |   2721256 | NS      | $64575404.88  | 0.80%             |  |  |  | No            |                  1 | On Loan: —       |
| Vaxcyte Inc                        | Vaxcyte Inc                                                                 | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |   1837447 | NS      | $88105583.65  | 1.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Sorrento Therapeutics Inc          | Sorrento Therapeutics Inc                                                   | CUSIP: 83587F202<br>LEI: 549300RH23PRR3M13410 | Long             | EC               | CORP              | US        |  41245100 | NS      | $36543158.60  | 0.45%             |  |  |  | No            |                  1 | On Loan: —       |
| Blueprint Medicines Corp           | Blueprint Medicines Corp                                                    | CUSIP: 09627Y109<br>LEI: 5299004CC60O9T5HVM83 | Long             | EC               | CORP              | US        |   1648962 | NS      | $72241025.22  | 0.89%             |  |  |  | No            |                  1 | On Loan: No      |
| Morphic Holding Inc                | Morphic Holding Inc                                                         | CUSIP: 61775R105<br>LEI: 549300RWWOUFLHTY1224 | Long             | EC               | CORP              | US        |   1057446 | NS      | $28286680.50  | 0.35%             |  |  |  | No            |                  1 | On Loan: —       |
| CareDx Inc                         | CareDx Inc                                                                  | CUSIP: 14167L103<br>LEI: 549300NQOFKL9NON0U06 | Long             | EC               | CORP              | US        |   4687443 | NS      | $53483724.63  | 0.66%             |  |  |  | No            |                  1 | On Loan: —       |
| Bridgebio Pharma Inc               | Bridgebio Pharma Inc                                                        | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |   6233460 | NS      | $47498965.20  | 0.59%             |  |  |  | No            |                  1 | On Loan: —       |
| Prothena Corp PLC                  | Prothena Corp PLC                                                           | CUSIP: 000000000<br>LEI: 5299009ZXQ8NIIJ8OL30 | Long             | EC               | CORP              | IE        |   1334591 | NS      | $80409107.75  | 0.99%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvalent Inc                       | Nuvalent Inc                                                                | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    466860 | NS      | $13903090.80  | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Kymera Therapeutics Inc            | Kymera Therapeutics Inc                                                     | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2080889 | NS      | $51938989.44  | 0.64%             |  |  |  | No            |                  1 | On Loan: —       |
| Dynavax Technologies Corp          | Dynavax Technologies Corp                                                   | CUSIP: 268158201<br>LEI: 549300T5URIXWDILX594 | Long             | EC               | CORP              | US        |   6245937 | NS      | $66456769.68  | 0.82%             |  |  |  | No            |                  1 | On Loan: —       |
| Deciphera Pharmaceuticals Inc      | Deciphera Pharmaceuticals Inc                                               | CUSIP: 24344T101<br>LEI: 529900QR4WAPYY0CBF25 | Long             | EC               | CORP              | US        |   2439743 | NS      | $39987387.77  | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcellx Inc                        | Arcellx Inc                                                                 | CUSIP: 03940C100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1065110 | NS      | $32997107.80  | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| IVERIC bio Inc                     | IVERIC bio Inc                                                              | CUSIP: 46583P102<br>LEI: 549300GZXI59U71XPM70 | Long             | EC               | CORP              | US        |   3846524 | NS      | $82354078.84  | 1.02%             |  |  |  | No            |                  1 | On Loan: No      |
| iTeos Therapeutics Inc             | iTeos Therapeutics Inc                                                      | CUSIP: 46565G104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    992834 | NS      | $19390048.02  | 0.24%             |  |  |  | No            |                  1 | On Loan: —       |
| TG Therapeutics Inc                | TG Therapeutics Inc                                                         | CUSIP: 88322Q108<br>LEI: 529900X21UKABN9NJ529 | Long             | EC               | CORP              | US        |   7259547 | NS      | $85880441.01  | 1.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Sarepta Therapeutics Inc           | Sarepta Therapeutics Inc                                                    | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |    658117 | NS      | $85278800.86  | 1.05%             |  |  |  | No            |                  1 | On Loan: No      |
| ACHILLION PHARMACE                 | ACHILLION PHARMACE                                                          | CUSIP: 004CVR031<br>LEI: 529900LZPJ796VSWZM38 | N/A              | DE               |  | US        |     51865 | NS      | $75463.58     | 0.00%             |  |  |  | No            |                  2 | On Loan: —       |
| FibroGen Inc                       | FibroGen Inc                                                                | CUSIP: 31572Q808<br>LEI: 549300Q914ULWWY95822 | Long             | EC               | CORP              | US        |   2507925 | NS      | $40176958.50  | 0.50%             |  |  |  | No            |                  1 | On Loan: —       |
| Gossamer Bio Inc                   | Gossamer Bio Inc                                                            | CUSIP: 38341P102<br>LEI: 549300ZOC0N2W6PSFR58 | Long             | EC               | CORP              | US        |  26765428 | NS      | $58080978.76  | 0.72%             |  |  |  | No            |                  1 | On Loan: —       |
| Sangamo Therapeutics Inc           | Sangamo Therapeutics Inc                                                    | CUSIP: 800677106<br>LEI: 2549006WMRKRC4G32Z67 | Long             | EC               | CORP              | US        |   6823781 | NS      | $21426672.34  | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| OMNIAB INC                         | OMNIAB INC                                                                  | CUSIP: 68218J202<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    161960 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  3 | On Loan: —       |
| Ultragenyx Pharmaceutical Inc      | Ultragenyx Pharmaceutical Inc                                               | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |   1916156 | NS      | $88775507.48  | 1.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Insmed Inc                         | Insmed Inc                                                                  | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |   4219687 | NS      | $84309346.26  | 1.04%             |  |  |  | No            |                  1 | On Loan: No      |
| RAPT Therapeutics Inc              | RAPT Therapeutics Inc                                                       | CUSIP: 75382E109<br>LEI: 549300MB473BIU78ES48 | Long             | EC               | CORP              | US        |   1415557 | NS      | $28028028.60  | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcus Biosciences Inc              | Arcus Biosciences Inc                                                       | CUSIP: 03969F109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1882245 | NS      | $38924826.60  | 0.48%             |  |  |  | No            |                  1 | On Loan: —       |
| Arcutis Biotherapeutics Inc        | Arcutis Biotherapeutics Inc                                                 | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2928069 | NS      | $43335421.20  | 0.54%             |  |  |  | No            |                  1 | On Loan: —       |
| Vir Biotechnology Inc              | Vir Biotechnology Inc                                                       | CUSIP: 92764N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2980382 | NS      | $75433468.42  | 0.93%             |  |  |  | No            |                  1 | On Loan: No      |
| Design Therapeutics Inc            | Design Therapeutics Inc                                                     | CUSIP: 25056L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2352153 | NS      | $24133089.78  | 0.30%             |  |  |  | No            |                  1 | On Loan: —       |
| Vericel Corp                       | Vericel Corp                                                                | CUSIP: 92346J108<br>LEI: 54930076YM3PLTDR4B91 | Long             | EC               | CORP              | US        |   1682682 | NS      | $44321843.88  | 0.55%             |  |  |  | No            |                  1 | On Loan: —       |
| Altimmune Inc                      | Altimmune Inc                                                               | CUSIP: 02155H200<br>LEI: 549300EOYCQ8SW3NVE64 | Long             | EC               | CORP              | US        |   5784914 | NS      | $95161835.30  | 1.18%             |  |  |  | No            |                  1 | On Loan: —       |
| Cogent Biosciences Inc             | Cogent Biosciences Inc                                                      | CUSIP: 19240Q201<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   3128211 | NS      | $36162119.16  | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Emergent BioSolutions Inc          | Emergent BioSolutions Inc                                                   | CUSIP: 29089Q105<br>LEI: 549300YW6TUOX8BE5103 | Long             | EC               | CORP              | US        |   4014190 | NS      | $47407583.90  | 0.59%             |  |  |  | No            |                  1 | On Loan: —       |
| Natera Inc                         | Natera Inc                                                                  | CUSIP: 632307104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2042394 | NS      | $82042966.98  | 1.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Neurocrine Biosciences Inc         | Neurocrine Biosciences Inc                                                  | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |    664272 | NS      | $79340647.68  | 0.98%             |  |  |  | No            |                  1 | On Loan: No      |
| Exelixis Inc                       | Exelixis Inc                                                                | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |   4939333 | NS      | $79226901.32  | 0.98%             |  |  |  | No            |                  1 | On Loan: No      |
| Editas Medicine Inc                | Editas Medicine Inc                                                         | CUSIP: 28106W103<br>LEI: 5299000AON4Q9NT2JE42 | Long             | EC               | CORP              | US        |   7446435 | NS      | $66049878.45  | 0.82%             |  |  |  | No            |                  1 | On Loan: —       |
| Crinetics Pharmaceuticals Inc      | Crinetics Pharmaceuticals Inc                                               | CUSIP: 22663K107<br>LEI: 549300Q1CNFXK5P31D28 | Long             | EC               | CORP              | US        |   1027990 | NS      | $18812217.00  | 0.23%             |  |  |  | No            |                  1 | On Loan: —       |
| Cytokinetics Inc                   | Cytokinetics Inc                                                            | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |   2177648 | NS      | $99779831.36  | 1.23%             |  |  |  | No            |                  1 | On Loan: —       |
| Inhibrx Inc                        | Inhibrx Inc                                                                 | CUSIP: 45720L107<br>LEI: 549300VBKG2LTV1TLY22 | Long             | EC               | CORP              | US        |   1900887 | NS      | $46837855.68  | 0.58%             |  |  |  | No            |                  1 | On Loan: —       |
| Regeneron Pharmaceuticals Inc      | Regeneron Pharmaceuticals Inc                                               | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |    103813 | NS      | $74900041.37  | 0.93%             |  |  |  | No            |                  1 | On Loan: No      |
| Nurix Therapeutics Inc             | Nurix Therapeutics Inc                                                      | CUSIP: 67080M103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1594032 | NS      | $17502471.36  | 0.22%             |  |  |  | No            |                  1 | On Loan: —       |
| Syndax Pharmaceuticals Inc         | Syndax Pharmaceuticals Inc                                                  | CUSIP: 87164F105<br>LEI: 529900OF94TRHKZVBS87 | Long             | EC               | CORP              | US        |   2558346 | NS      | $65109905.70  | 0.80%             |  |  |  | No            |                  1 | On Loan: —       |
| REGENXBIO Inc                      | REGENXBIO Inc                                                               | CUSIP: 75901B107<br>LEI: 549300EOES47LATSET33 | Long             | EC               | CORP              | US        |   1383167 | NS      | $31370227.56  | 0.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Immunovant Inc                     | Immunovant Inc                                                              | CUSIP: 45258J102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2227768 | NS      | $39542882.00  | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Day One Biopharmaceuticals Inc     | Day One Biopharmaceuticals Inc                                              | CUSIP: 23954D109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1983679 | NS      | $42688772.08  | 0.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Rocket Pharmaceuticals Inc         | Rocket Pharmaceuticals Inc                                                  | CUSIP: 77313F106<br>LEI: 549300R7VV82YUIN4Y93 | Long             | EC               | CORP              | US        |   2837774 | NS      | $55535237.18  | 0.69%             |  |  |  | No            |                  1 | On Loan: —       |
| Atara Biotherapeutics Inc          | Atara Biotherapeutics Inc                                                   | CUSIP: 046513107<br>LEI: 549300WBXUXZRE03MS38 | Long             | EC               | CORP              | US        |   4856254 | NS      | $15928513.12  | 0.20%             |  |  |  | No            |                  1 | On Loan: —       |
| EQRx Inc                           | EQRx Inc                                                                    | CUSIP: 26886C107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |  11872466 | NS      | $29206266.36  | 0.36%             |  |  |  | No            |                  1 | On Loan: —       |
| Coherus Biosciences Inc            | Coherus Biosciences Inc                                                     | CUSIP: 19249H103<br>LEI: 5493007IL8W5MV932D26 | Long             | EC               | CORP              | US        |   4533431 | NS      | $35904773.52  | 0.44%             |  |  |  | No            |                  1 | On Loan: —       |
| Alkermes PLC                       | Alkermes PLC                                                                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | IE        |   3153533 | NS      | $82401817.29  | 1.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Amicus Therapeutics Inc            | Amicus Therapeutics Inc                                                     | CUSIP: 03152W109<br>LEI: 549300MRD1SMUTNBPQ53 | Long             | EC               | CORP              | US        |   6663222 | NS      | $81357940.62  | 1.01%             |  |  |  | No            |                  1 | On Loan: No      |
| C4 Therapeutics Inc                | C4 Therapeutics Inc                                                         | CUSIP: 12529R107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1716867 | NS      | $10129515.30  | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC Therapeutics Inc               | PTC Therapeutics Inc                                                        | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |   2042346 | NS      | $77956346.82  | 0.96%             |  |  |  | No            |                  1 | On Loan: —       |
| Novavax Inc                        | Novavax Inc                                                                 | CUSIP: 670002401<br>LEI: 529900J4GJHPEPQ23205 | Long             | EC               | CORP              | US        |   4717964 | NS      | $48500669.92  | 0.60%             |  |  |  | No            |                  1 | On Loan: —       |
| Karyopharm Therapeutics Inc        | Karyopharm Therapeutics Inc                                                 | CUSIP: 48576U106<br>LEI: 549300J1VANRCNTYST87 | Long             | EC               | CORP              | US        |   6727111 | NS      | $22872177.40  | 0.28%             |  |  |  | No            |                  1 | On Loan: —       |
| SpringWorks Therapeutics Inc       | SpringWorks Therapeutics Inc                                                | CUSIP: 85205L107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   3076013 | NS      | $80007098.13  | 0.99%             |  |  |  | No            |                  1 | On Loan: —       |
| uniQure NV                         | uniQure NV                                                                  | CUSIP: 000000000<br>LEI: 724500RPCTZLFYJZ3S98 | Long             | EC               | CORP              | NL        |   1907144 | NS      | $43234954.48  | 0.53%             |  |  |  | No            |                  1 | On Loan: No      |
| 4D Molecular Therapeutics Inc      | 4D Molecular Therapeutics Inc                                               | CUSIP: 35104E100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    464578 | NS      | $10318277.38  | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Mirum Pharmaceuticals Inc          | Mirum Pharmaceuticals Inc                                                   | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |   1411079 | NS      | $27516040.50  | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Roivant Sciences Ltd               | Roivant Sciences Ltd                                                        | CUSIP: 000000000<br>LEI: 549300DL466NY5J6U724 | Long             | EC               | CORP              | BM        |   2475320 | NS      | $19777806.80  | 0.24%             |  |  |  | No            |                  1 | On Loan: —       |
| Xencor Inc                         | Xencor Inc                                                                  | CUSIP: 98401F105<br>LEI: 549300V5IF65437JKG30 | Long             | EC               | CORP              | US        |   1124354 | NS      | $29278178.16  | 0.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Allogene Therapeutics Inc          | Allogene Therapeutics Inc                                                   | CUSIP: 019770106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   7306022 | NS      | $45954878.38  | 0.57%             |  |  |  | No            |                  1 | On Loan: —       |
| State Street Global Advisors       | State Street Institutional Liquid Reserves Fund                             | CUSIP: 85749P101<br>LEI: 5493000HFJPORCLSV250 | Long             | STIV             | RF                | US        |   3567024 | NS      | $3567737.08   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Agenus Inc                         | Agenus Inc                                                                  | CUSIP: 00847G705<br>LEI: 529900NDQQGU5H4UJK81 | Long             | EC               | CORP              | US        |  16900535 | NS      | $40561284.00  | 0.50%             |  |  |  | No            |                  1 | On Loan: —       |
| Gilead Sciences Inc                | Gilead Sciences Inc                                                         | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |    885494 | NS      | $76019659.90  | 0.94%             |  |  |  | No            |                  1 | On Loan: No      |
| MannKind Corp                      | MannKind Corp                                                               | CUSIP: 56400P706<br>LEI: 213800GFBCNY1ZFST722 | Long             | EC               | CORP              | US        |  12384151 | NS      | $65264475.77  | 0.81%             |  |  |  | No            |                  1 | On Loan: —       |
| Zentalis Pharmaceuticals Inc       | Zentalis Pharmaceuticals Inc                                                | CUSIP: 98943L107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2214350 | NS      | $44597009.00  | 0.55%             |  |  |  | No            |                  1 | On Loan: —       |

### Signature

**Date Signed:** 2023-01-23

**Name of Applicant:** SPDR SERIES TRUST

**Signature:** Arthur Jensen

**Name of Signer:** Arthur Jensen

**Title:** Deputy Treasurer