# EDGAR Filing Document

**Accession Number:** 0001263508
**File Stem:** 0001104659-25-085731
**Filing Date:** 2025-8
**Character Count:** 42770
**Document Hash:** 8a1675286f02aa437aeb9007b49721ee
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-25-085731.hdr.sgml**: 20250829

**ACCESSION NUMBER**: 0001104659-25-085731

**CONFORMED SUBMISSION TYPE**: N-PX

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20250630

**FILED AS OF DATE**: 20250829

**EFFECTIVENESS DATE**: 20250829

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** BAKER BROS. ADVISORS LP
- **CENTRAL INDEX KEY:** 0001263508

**ORGANIZATION NAME:**
- **EIN:** 134093645
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** N-PX
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-10519
- **FILM NUMBER:** 251281447

**BUSINESS ADDRESS:**
- **STREET 1:** 860 WASHINGTON STREET
- **STREET 2:** 3RD FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10014
- **BUSINESS PHONE:** 2123395600

**MAIL ADDRESS:**
- **STREET 1:** 860 WASHINGTON STREET
- **STREET 2:** 3RD FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10014

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** BAKER BROS ADVISORS LLC
- **DATE OF NAME CHANGE:** 20030911

## FORM N-PX
### ANNUAL REPORT OF PROXY VOTING RECORD

## N-PX: Filer Information

**Filer CIK:** 0001263508

**Date of Report:** 06/30/2025

**Are you a Registered Management Investment Company or an Institutional Manager?:** Institutional Manager

**Is this a LIVE or TEST Filing?:** LIVE

**Is this an electronic copy of an official filing submitted in paper format?:** [ ]

### Submission Contact Information
_Not provided in this filing._

### Notification Information
**Notify via Filing Website only?:** [ ]

## N-PX: Cover Page

**Name of reporting person:** BAKER BROS. ADVISORS LP

**Address:** 860 WASHINGTON STREET, NEW YORK, NY 10014

**Telephone number:** 212-339-5690

**Name of agent for service:** —

**Agent Address:** —, —, — —

**Reporting Period:** Report for the year ended 06/30/2025

**SEC File Number:** 028-10519

**CRD Number (if any):** —

**Other SEC File Number (if any):** —

**LEI (if any):** 549300QYZVDO3190ER85

**Report Type (check only one):**

Institutional Manager.

- [x] Institutional Manager Voting Report

- [ ] Institutional Manager Notice Report

- [ ] Institutional Manager Combination Report

Registered Management Investment Company.

- [ ] Fund Voting Report

- [ ] Fund Notice Report

**Do you wish to provide explanatory information pursuant to Special Instruction B.4?:**

- [x] No

- [ ] Yes

**Additional information:** —

## N-PX: Summary - Included Managers

**Number of Included Institutional Managers:** 0

**Included Institutional Managers:** —

## FORM N-PX PROXY VOTING RECORD

| NAME OF ISSUER                           | CUSIP     | MEETING DATE   | VOTE DESCRIPTION                                                                                                                                                                                                                                                                                                            | VOTE CATEGORY                |   SHARES VOTED |   SHARES ON LOAN | HOW VOTED   | SHARES VOTED FOR OR AGAINST MANAGEMENT   | FOR OR AGAINST MANAGEMENT   | OTHER INFO   |
|:---|:---|:---|:---|:---|---:|---:|:---|:---|:---|:---|
| ABCELLERA BIOLOGICS INC.                 | 00288U106 | 06/12/2025     | To approve, on a non-binding advisory basis, the compensation of the Company's named executive officers, or Say-on-Pay.                                                                                                                                                                                                     | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| ACADIA PHARMACEUTICALS INC.              | 004225108 | 05/29/2025     | To approve, on an advisory basis, the compensation of the Company's named executive officers, as disclosed in the proxy statement.                                                                                                                                                                                          | SECTION 14A SAY-ON-PAY VOTES |       43083688 |                0 | FOR         | 43083688                                 | FOR                         |  |
| AGIOS PHARMACEUTICALS, INC.              | 00847X104 | 06/18/2025     | To vote, on an advisory basis, to approve the compensation paid to our named executive officers.                                                                                                                                                                                                                            | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| AKERO THERAPEUTICS, INC                  | 00973Y108 | 06/03/2025     | To consider and act upon a non-binding, advisory vote to approve the compensation of our named executive officers.                                                                                                                                                                                                          | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| ALKERMES PLC                             | G01767105 | 05/21/2025     | To approve, in a non-binding, advisory vote, the compensation of the Company's named executive officers.                                                                                                                                                                                                                    | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| ARGENX SE                                | 04016X101 | 05/27/2025     | The 2024 remuneration report                                                                                                                                                                                                                                                                                                | SECTION 14A SAY-ON-PAY VOTES |           6504 |                0 | FOR         | 6504                                     | FOR                         |  |
| BEIGENE LTD                              | 07725L102 | 05/21/2025     | That, on a non-binding, advisory basis, the compensation of the Company's named executive officers, as disclosed in the Proxy Statement, be and is hereby approved.                                                                                                                                                         | SECTION 14A SAY-ON-PAY VOTES |        8819889 |                0 | FOR         | 8819889                                  | FOR                         |  |
| BEIGENE LTD                              | G1146Y101 | 05/21/2025     | That, On A Non-Binding, Advisory Basis, The Compensation Of The Companys Named Executive Officers, As Disclosed In The Proxy Statement, Be And Is Hereby Approved                                                                                                                                                           | SECTION 14A SAY-ON-PAY VOTES |          46744 |                0 | FOR         | 46744                                    | FOR                         |  |
| BICYCLE THERAPEUTICS PLC                 | 088786108 | 06/17/2025     | To approve, on advisory basis, the compensation of our named executive officers, as disclosed in the proxy statement.                                                                                                                                                                                                       | SECTION 14A SAY-ON-PAY VOTES |       10885357 |                0 | FOR         | 10885357                                 | FOR                         |  |
| BLUEPRINT MEDICINES CORPORATION          | 09627Y109 | 06/18/2025     | Approval of a non-binding advisory vote on the compensation paid to our named executive officers.                                                                                                                                                                                                                           | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| CELCUITY INC.                            | 15102K100 | 05/13/2025     | To approve, by a non-binding and advisory vote, compensation of the named executive officers.                                                                                                                                                                                                                               | SECTION 14A SAY-ON-PAY VOTES |        4023920 |                0 | FOR         | 4023920                                  | FOR                         |  |
| CELLDEX THERAPEUTICS, INC.               | 15117B202 | 06/05/2025     | To approve, on an advisory basis, the compensation of the Company's Named Executive Officers as disclosed in the Proxy Statement.                                                                                                                                                                                           | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| CERUS CORPORATION                        | 157085101 | 06/03/2025     | Advisory Votes on Executive Compensation: The approval, on an advisory basis, of the compensation of the Company's named executive officers as disclosed in the Proxy Statement.                                                                                                                                            | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| CRINETICS PHARMACEUTICALS INC.           | 22663K107 | 06/11/2025     | To consider and vote upon, on an advisory basis, the compensation of the Company's named executive officers as disclosed in the proxy statement pursuant to the compensation disclosure rules of the Securities and Exchange Commission.                                                                                    | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| DBV TECHNOLOGIES S.A.                    | 23306J309 | 06/11/2025     | Approval Of The Fixed, Variable And Exceptional Elements Making Up The Total Remuneration And Benefits Of Any Kind, Paid During The Financial Year 2024 Or Awarded For The Same Financial Year To Mr. Michel De Rosen, Chairman Of The Board Of Directors                                                                   | SECTION 14A SAY-ON-PAY VOTES |        1461425 |                0 | FOR         | 1461425                                  | FOR                         |  |
| DBV TECHNOLOGIES S.A.                    | 23306J309 | 06/11/2025     | Approval Of The Fixed, Variable And Exceptional Elements Making Up The Total Remuneration And Benefits Of Any Kind, Paid During The Financial Year 2024 Or Awarded For The Same Financial Year To Mr. Daniel Tasse, Chief Executive Officer                                                                                 | SECTION 14A SAY-ON-PAY VOTES |        1461425 |                0 | FOR         | 1461425                                  | FOR                         |  |
| DBV TECHNOLOGIES S.A.                    | 23306J309 | 06/11/2025     | Consultative Opinion On The Remuneration Of Executive Managers Named Executive Officers' Other Than The Chief Executive Officer                                                                                                                                                                                             | SECTION 14A SAY-ON-PAY VOTES |        1461425 |                0 | FOR         | 1461425                                  | FOR                         |  |
| DBV TECHNOLOGIES SA                      | F2927N109 | 06/11/2025     | Approval Of The Fixed, Variable And Exceptional Elements Making Up The Total Remuneration And Benefits Of Any Kind, Paid During The Financial Year 2024 Or Awarded For The Same Financial Year To Mr. Michel De Rosen, Chairman Of The Board Of Directors                                                                   | SECTION 14A SAY-ON-PAY VOTES |       16161038 |                0 | FOR         | 16161038                                 | FOR                         |  |
| DBV TECHNOLOGIES SA                      | F2927N109 | 06/11/2025     | Approval Of The Fixed, Variable And Exceptional Elements Making Up The Total Remuneration And Benefits Of Any Kind, Paid During The Financial Year 2024 Or Awarded For The Same Financial Year To Mr. Daniel Tasse, Chief Executive Officer                                                                                 | SECTION 14A SAY-ON-PAY VOTES |       16161038 |                0 | FOR         | 16161038                                 | FOR                         |  |
| DBV TECHNOLOGIES SA                      | F2927N109 | 06/11/2025     | Consultative Opinion On The Remuneration Of Executive Managers 'Named Executive Officers' Other Than The Chief Executive Officer                                                                                                                                                                                            | SECTION 14A SAY-ON-PAY VOTES |       16161038 |                0 | FOR         | 16161038                                 | FOR                         |  |
| DENALI THERAPEUTICS INC.                 | 24823R105 | 06/03/2025     | Advisory vote on executive compensation                                                                                                                                                                                                                                                                                     | SECTION 14A SAY-ON-PAY VOTES |        3731695 |                0 | FOR         | 3731695                                  | FOR                         |  |
| DISC MEDICINE, INC.                      | 254604101 | 06/11/2025     | To approve, on a non-binding, advisory basis, the compensation paid to the Company's named executive officers.                                                                                                                                                                                                              | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| DISC MEDICINE, INC.                      | 254604101 | 06/11/2025     | To recommend, by a non-binding advisory vote, the frequency of future advisory votes on the compensation paid to the Company's named executive officers.                                                                                                                                                                    | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| DYNE THERAPEUTICS, INC.                  | 26818M108 | 05/30/2025     | To vote, on an advisory basis, to approve the compensation of our named executive officers.                                                                                                                                                                                                                                 | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| DYNE THERAPEUTICS, INC.                  | 26818M108 | 05/30/2025     | To hold an advisory vote on the frequency of future advisory votes on the compensation of our named executive officers.                                                                                                                                                                                                     | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| EDGEWISE THERAPEUTICS INC                | 28036F105 | 06/13/2025     | Conduct an advisory vote on the compensation of our named executive officers.                                                                                                                                                                                                                                               | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| EDGEWISE THERAPEUTICS INC                | 28036F105 | 06/13/2025     | Conduct an advisory vote on the frequency of future advisory votes on the compensation of our named executive officers.                                                                                                                                                                                                     | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| FATE THERAPEUTICS, INC.                  | 31189P102 | 05/29/2025     | To approve, on a non-binding advisory basis, the compensation of the Company's named executive officers as disclosed in the proxy statement.                                                                                                                                                                                | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| FATE THERAPEUTICS, INC.                  | 31189P102 | 05/29/2025     | To recommend, on a non-binding advisory basis, the frequency of future non-binding stockholder advisory votes to approve the compensation of the Company's named executive officers.                                                                                                                                        | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| GENERATION BIO CO.                       | 37148K100 | 06/04/2025     | Approval, on an advisory (non-binding) basis, of the compensation of our named executive officers.                                                                                                                                                                                                                          | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| IDEAYA BIOSCIENCES, INC.                 | 45166A102 | 06/24/2025     | To approve, on a non-binding, advisory basis, the compensation of the Company's named executive officers as disclosed in the Proxy Statement accompanying this Notice of Annual Meeting of Stockholders.                                                                                                                    | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| IMMUNOCORE HOLDINGS PLC                  | 45258D105 | 05/15/2025     | To approve, on advisory basis, the compensation of our named executive officers, as disclosed in the proxy statement.                                                                                                                                                                                                       | SECTION 14A SAY-ON-PAY VOTES |        2322656 |                0 | FOR         | 2322656                                  | FOR                         |  |
| IMMUNOVANT INC                           | 45258J102 | 08/12/2024     | To approve, on a non-binding, advisory basis, the compensation of our named executive officers.                                                                                                                                                                                                                             | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| INCYTE CORPORATION                       | 45337C102 | 06/10/2025     | Approve, on a non-binding, advisory basis, the compensation of the Company's named executive officers.                                                                                                                                                                                                                      | SECTION 14A SAY-ON-PAY VOTES |       31336156 |                0 | FOR         | 31336156                                 | FOR                         |  |
| INSMED INCORPORATED                      | 457669307 | 05/15/2025     | An advisory vote on the 2024 compensation of our named executive officers.                                                                                                                                                                                                                                                  | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| INTELLIA THERAPEUTICS, INC.              | 45826J105 | 06/11/2025     | Approval, on a non-binding advisory basis, of the compensation of our named executive officers ("NEOs").                                                                                                                                                                                                                    | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| INTELLIA THERAPEUTICS, INC.              | 45826J105 | 06/11/2025     | A non-binding advisory vote on the frequency of future non-binding advisory votes on the compensation of our NEOs.                                                                                                                                                                                                          | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| IONIS PHARMACEUTICALS, INC.              | 462222100 | 06/05/2025     | To make an advisory vote on executive compensation.                                                                                                                                                                                                                                                                         | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| JANUX THERAPEUTICS, INC.                 | 47103J105 | 06/11/2025     | Approval, on an advisory basis, of the compensation of our named executive officers ("Say-On-Pay"), as disclosed in the accompanying Proxy Statement.                                                                                                                                                                       | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| JANUX THERAPEUTICS, INC.                 | 47103J105 | 06/11/2025     | Indication, on an advisory basis, of the preferred frequency of holding future Say-On-Pay votes on the compensation of our named executive officers.                                                                                                                                                                        | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| KINIKSA PHARMACEUTICAL INTERNATIONAL PLC | G52694109 | 06/03/2025     | To approve, on an advisory (non-binding) basis, the Company's UK Statutory Directors' Annual Remuneration Report for the period ended December 31, 2024.                                                                                                                                                                    | SECTION 14A SAY-ON-PAY VOTES |        2848003 |                0 | FOR         | 2848003                                  | FOR                         |  |
| KINIKSA PHARMACEUTICAL INTERNATIONAL PLC | G52694109 | 06/03/2025     | To approve, on an advisory (non-binding) basis, the compensation of our named executive officers.                                                                                                                                                                                                                           | SECTION 14A SAY-ON-PAY VOTES |        2848003 |                0 | FOR         | 2848003                                  | FOR                         |  |
| KODIAK SCIENCES INC.                     | 50015M109 | 06/02/2025     | Approve, on an advisory basis, the compensation of Kodiak's named executive officers, as disclosed in the proxy statement.                                                                                                                                                                                                  | SECTION 14A SAY-ON-PAY VOTES |       17310490 |                0 | FOR         | 17310490                                 | FOR                         |  |
| KYMERA THERAPEUTICS, INC.                | 501575104 | 06/25/2025     | To approve, on a non-binding advisory basis, the compensation of our named executive officers.                                                                                                                                                                                                                              | SECTION 14A SAY-ON-PAY VOTES |        5995929 |                0 | FOR         | 5995929                                  | FOR                         |  |
| LEAP THERAPEUTICS, INC.                  | 52187K200 | 07/02/2024     | Advisory vote on executive compensation paid to named executive officers ("Say-on-Pay Proposal").                                                                                                                                                                                                                           | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| LEAP THERAPEUTICS, INC.                  | 52187K200 | 06/18/2025     | Advisory vote on executive compensation paid to named executive officers ("Say-on-Pay Proposal").                                                                                                                                                                                                                           | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| MADRIGAL PHARMACEUTICALS INC.            | 558868105 | 06/20/2025     | Advisory vote to approve executive compensation                                                                                                                                                                                                                                                                             | SECTION 14A SAY-ON-PAY VOTES |        1974590 |                0 | FOR         | 1974590                                  | FOR                         |  |
| MADRIGAL PHARMACEUTICALS INC.            | 558868105 | 06/20/2025     | Advisory vote to approve the frequency of future advisory votes to approve executive compensation                                                                                                                                                                                                                           | SECTION 14A SAY-ON-PAY VOTES |        1974590 |                0 | 1 YEAR      | 1974590                                  | FOR                         |  |
| NEUROGENE INC.                           | 64135M105 | 06/12/2025     | To approve on an advisory (non-binding) basis the compensation of the Company's named executive officers.                                                                                                                                                                                                                   | SECTION 14A SAY-ON-PAY VOTES |         962740 |                0 | FOR         | 962740                                   | FOR                         |  |
| NURIX THERAPEUTICS, INC.                 | 67080M103 | 05/19/2025     | To approve, on a non-binding advisory basis, the compensation of the Company's named executive officers as disclosed in the Proxy Statement.                                                                                                                                                                                | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| NUVALENT, INC.                           | 670703107 | 06/18/2025     | To approve, on an advisory basis, the compensation paid to our named executive officers.                                                                                                                                                                                                                                    | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| OPTHEA LIMITED                           | 68386J208 | 11/15/2024     | Adoption of remuneration report.                                                                                                                                                                                                                                                                                            | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| OPTHEA LTD                               | Q7150T101 | 11/15/2024     | Adoption Of Remuneration Report                                                                                                                                                                                                                                                                                             | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| PRAXIS PRECISION MEDICINES, INC.         | 74006W207 | 06/26/2025     | To approve, on an advisory (non-binding) basis, the compensation of the named executive officers as disclosed in the Company's proxy statement for the 2025 Annual Meeting of Stockholders pursuant to the applicable compensation disclosure rules of the SEC, including the compensation tables and narrative discussion. | SECTION 14A SAY-ON-PAY VOTES |         689488 |                0 | FOR         | 689488                                   | FOR                         |  |
| PROTARA THERAPEUTICS, INC.               | 74365U107 | 06/11/2025     | Approval, on an advisory basis, of the compensation of Protara Therapeutics, Inc.'s named executive officers, as disclosed in the proxy statement                                                                                                                                                                           | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| RELAY THERAPEUTICS, INC.                 | 75943R102 | 06/06/2025     | To consider and act upon an advisory vote on the compensation of our named executive officers.                                                                                                                                                                                                                              | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| REPLIMUNE GROUP INC                      | 76029N106 | 09/04/2024     | To approve, on a non-binding advisory basis, the compensation of Replimune Group, Inc.'s named executive officers.                                                                                                                                                                                                          | SECTION 14A SAY-ON-PAY VOTES |       10045336 |                0 | FOR         | 10045336                                 | FOR                         |  |
| REPLIMUNE GROUP INC                      | 76029N106 | 09/04/2024     | To approve, on a non-binding advisory basis, the preferred frequency of future advisory votes on the compensation of Replimune Group, Inc.'s named executive officers.                                                                                                                                                      | SECTION 14A SAY-ON-PAY VOTES |       10045336 |                0 | 1 YEAR      | 10045336                                 | FOR                         |  |
| REVOLUTION MEDICINES, INC.               | 76155X100 | 06/26/2025     | To approve, on a non-binding, advisory basis, the compensation of the Company's named executive officers as disclosed in the Proxy Statement pursuant to the compensation disclosure rules of the Securities and Exchange Commission ("Say-on-Pay").                                                                        | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| RHYTHM PHARMACEUTICALS, INC.             | 76243J105 | 09/18/2024     | Approval, on an advisory (non-binding) basis, of the compensation of the named executive officers of the Company.                                                                                                                                                                                                           | SECTION 14A SAY-ON-PAY VOTES |        6398365 |                0 | FOR         | 6398365                                  | FOR                         |  |
| RHYTHM PHARMACEUTICALS, INC.             | 76243J105 | 06/24/2025     | Approval, on an advisory (non-binding) basis, of the compensation of the named executive officers of the Company.                                                                                                                                                                                                           | SECTION 14A SAY-ON-PAY VOTES |        5604483 |                0 | FOR         | 5604483                                  | FOR                         |  |
| ROCKET PHARMACEUTICALS, INC.             | 77313F106 | 06/18/2025     | Consider and act upon a non-binding, advisory vote on the compensation of our named executive officers.                                                                                                                                                                                                                     | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| ROIVANT SCIENCES LTD                     | G76279101 | 09/10/2024     | To cast a non-binding, advisory vote to approve the compensation of our named executive officers.                                                                                                                                                                                                                           | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| ROIVANT SCIENCES LTD                     | G76279101 | 09/10/2024     | To cast a non-binding, advisory vote on the frequency of future non-binding, advisory votes to approve the compensation of our named executive officers every.                                                                                                                                                              | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| SCHOLAR ROCK HOLDING CORPORATION         | 80706P103 | 05/22/2025     | To approve, on a non-binding, advisory basis, the compensation of the Company's named executive officers.                                                                                                                                                                                                                   | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| SKYE BIOSCIENCE, INC.                    | 83086J200 | 06/06/2025     | Consider and vote upon, on an advisory basis, the compensation of our named executive officers as disclosed in this proxy statement pursuant to the compensation disclosure rules of the Securities and Exchange Commission.                                                                                                | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| SKYE BIOSCIENCE, INC.                    | 83086J200 | 06/06/2025     | Consider and vote upon, on an advisory basis, whether the stockholder vote to approve the compensation of the named executive officers as required by Section 14A(a)(2) of the Securities Exchange Act of 1934, as amended, should occur every one, two or three years.                                                     | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| STOKE THERAPEUTICS, INC.                 | 86150R107 | 06/03/2025     | To approve, on an advisory basis, the compensation of the Company's named executive officers.                                                                                                                                                                                                                               | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| STOKE THERAPEUTICS, INC.                 | 86150R107 | 06/03/2025     | To indicate, on an advisory basis, the preferred frequency of future stockholder advisory votes to approve the compensation of the Company's named executive officers.                                                                                                                                                      | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| STRUCTURE THERAPEUTICS, INC.             | 86366E106 | 06/23/2025     | To Approve, On An Advisory Basis, The Compensation Of The Company'S Named Executive Officers, As Disclosed In The Proxy Statement.                                                                                                                                                                                          | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| STRUCTURE THERAPEUTICS, INC.             | 86366E106 | 06/23/2025     | To Indicate, On An Advisory Basis, The Preferred Frequency Of Shareholder Advisory Votes On The Compensation Of The Company'S Named Executive Officers.                                                                                                                                                                     | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| ULTRAGENYX PHARMACEUTICAL INC.           | 90400D108 | 05/15/2025     | Advisory (non-binding) vote to approve the compensation of our named executive officers.                                                                                                                                                                                                                                    | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| VAXCYTE, INC.                            | 92243G108 | 06/12/2025     | Approval, on a non-binding, advisory basis, of the compensation of the Company's named executive officers.                                                                                                                                                                                                                  | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| VERONA PHARMA PLC                        | 925050106 | 04/24/2025     | To approve, on an advisory (non-binding) basis, the compensation of the Company's named executive officers.                                                                                                                                                                                                                 | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| VERVE THERAPEUTICS, INC.                 | 92539P101 | 06/05/2025     | Approval, on an advisory basis, of the compensation paid to our named executive officers.                                                                                                                                                                                                                                   | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| VIR BIOTECHNOLOGY, INC.                  | 92764N102 | 05/29/2025     | To approve, on an advisory basis, the compensation of the Company's named executive officers.                                                                                                                                                                                                                               | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| VIRIDIAN THERAPEUTICS, INC.              | 92790C104 | 06/20/2025     | To approve, on an advisory basis, the compensation of the Company's named executive officers.                                                                                                                                                                                                                               | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| XENCOR, INC.                             | 98401F105 | 06/12/2025     | To approve, on an advisory (non-binding) basis, the compensation of the Company's named executive officers, as disclosed in the accompanying Proxy Statement.                                                                                                                                                               | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |
| XENON PHARMACEUTICALS INC                | 98420N105 | 06/04/2025     | To approve, on an advisory basis, the compensation of the Corporation's named executive officers.                                                                                                                                                                                                                           | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 |  |  |  |  |

## N-PX: Signature Block

**Reporting Person:** BAKER BROS. ADVISORS LP

**By (Signature):** Alexandra A. Toohey

**By (Printed Signature):** Alexandra A. Toohey

**By (Title):** Chief Financial Officer

**Date:** 08/29/2025