# EDGAR Filing Document

**Accession Number:** 0001595725
**File Stem:** 0001172661-23-000999
**Filing Date:** 2023-2
**Character Count:** 17505
**Document Hash:** 94818f3040a40d29d5003878317193e8
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001172661-23-000999.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001172661-23-000999

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**EFFECTIVENESS DATE**: 20230214

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Rock Springs Capital Management LP
- **CENTRAL INDEX KEY:** 0001595725
- **IRS NUMBER:** 800944416
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-16048
- **FILM NUMBER:** 23624609

**BUSINESS ADDRESS:**
- **STREET 1:** 650 SOUTH EXETER STREET
- **STREET 2:** SUITE 1070
- **CITY:** BALTIMORE
- **STATE:** MD
- **ZIP:** 21202
- **BUSINESS PHONE:** 4102200129

**MAIL ADDRESS:**
- **STREET 1:** 650 SOUTH EXETER STREET
- **STREET 2:** SUITE 1070
- **CITY:** BALTIMORE
- **STATE:** MD
- **ZIP:** 21202

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2022

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** Rock Springs Capital Management LP<br>**Address:** 650 South Exeter Street<br>Suite 1070<br>Baltimore, MD 21202

**Form 13F File Number:** 028-16048

**CRD Number (if applicable):** 000168648

**SEC File Number (if applicable):** 801-78511

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Nnamdi Etoh<br>**Title:** Chief Financial Officer<br>**Phone:** 410-220-0129

**Signature, Place, and Date of Signing:**

/s/  Nnamdi Etoh  Baltimore, MD  02-14-2023<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 120

**Form 13F Information Table Value Total:** $4155902223

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| ABCAM PLC | ADS | 000380204 | BBG00XRJJM98 | 33920800 | 2180000 | SH |  | SOLE |  | 2180000 | 0 | 0 |
| ACADIA HEALTHCARE COMPANY IN | COM | 00404A109 | BBG001SNNWL7 | 69601560 | 845500 | SH |  | SOLE |  | 845500 | 0 | 0 |
| ACCOLADE INC | COM | 00437E102 | BBG00S2L1ZR1 | 15097020 | 1938000 | SH |  | SOLE |  | 1938000 | 0 | 0 |
| ACELRX PHARMACEUTICALS INC | COM NEW | 00444T209 | BBG001TFZCK5 | 715200 | 316460 | SH |  | SOLE |  | 316460 | 0 | 0 |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | BBG003LF0QS8 | 62389672 | 3961249 | SH |  | SOLE |  | 3961249 | 0 | 0 |
| ADAPTIMMUNE THERAPEUTICS PLC | SPONDS ADR | 00653A107 | BBG008G65WD1 | 3907743 | 2676536 | SH |  | SOLE |  | 2676536 | 0 | 0 |
| AEGLEA BIOTHERAPEUTICS INC | COM | 00773J103 | BBG0067L94C1 | 1535916 | 3413906 | SH |  | SOLE |  | 3413906 | 0 | 0 |
| AGILON HEALTH INC | COM | 00857U107 | BBG00HCYVQR3 | 127062150 | 7872500 | SH |  | SOLE |  | 7872500 | 0 | 0 |
| AGIOS PHARMACEUTICALS INC | COM | 00847X104 | BBG001T8R687 | 84144303 | 2996592 | SH |  | SOLE |  | 2996592 | 0 | 0 |
| AKERO THERAPEUTICS INC | COM | 00973Y108 | BBG00L9211Z7 | 76755839 | 1400654 | SH |  | SOLE |  | 1400654 | 0 | 0 |
| ALIGN TECHNOLOGY INC | COM | 016255101 | BBG001SCF1B9 | 63765615 | 302350 | SH |  | SOLE |  | 302350 | 0 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | BBG001S7FTC8 | 79018625 | 332500 | SH |  | SOLE |  | 332500 | 0 | 0 |
| ALTIMMUNE INC | COM NEW | 02155H200 | BBG001SNS461 | 3672545 | 223255 | SH |  | SOLE |  | 223255 | 0 | 0 |
| AMICUS THERAPEUTICS INC | COM | 03152W109 | BBG001SN96V9 | 12989071 | 1063806 | SH |  | SOLE |  | 1063806 | 0 | 0 |
| AMRYT PHARMA PLC | SPONSORED ADS | 03217L106 | BBG00Q9V0S11 | 9677063 | 1325625 | SH |  | SOLE |  | 1325625 | 0 | 0 |
| AMYLYX PHARMACEUTICALS INC | COM | 03237H101 | BBG00DP10YW1 | 45435087 | 1229637 | SH |  | SOLE |  | 1229637 | 0 | 0 |
| ANAPTYSBIO INC | COM | 032724106 | BBG0026ZDHT8 | 17868834 | 576600 | SH |  | SOLE |  | 576600 | 0 | 0 |
| APPLIED THERAPEUTICS INC | COM | 03828A101 | BBG001SMJMY2 | 453477 | 596680 | SH |  | SOLE |  | 596680 | 0 | 0 |
| ARGENX SE | SPONSORED ADR | 04016X101 | BBG00GHB88Y8 | 132590500 | 350000 | SH |  | SOLE |  | 350000 | 0 | 0 |
| ASCENDIS PHARMA A/S | SPONSORED ADR | 04351P101 | BBG007R7VP72 | 51966315 | 425500 | SH |  | SOLE |  | 425500 | 0 | 0 |
| ATRECA INC | CL A COM | 04965G109 | BBG003FJ19C1 | 290242 | 362530 | SH |  | SOLE |  | 362530 | 0 | 0 |
| AURA BIOSCIENCES INC | COM | 05153U107 | BBG00226DGP2 | 10707449 | 1019757 | SH |  | SOLE |  | 1019757 | 0 | 0 |
| AURINIA PHARMACEUTICALS INC | COM | 05156V102 | BBG001S68013 | 2071613 | 479540 | SH |  | SOLE |  | 479540 | 0 | 0 |
| AZENTA INC | COM | 114340102 | BBG001S8F1B8 | 20464330 | 351500 | SH |  | SOLE |  | 351500 | 0 | 0 |
| BAXTER INTL INC | COM | 071813109 | BBG001S5P1K3 | 58615500 | 1150000 | SH |  | SOLE |  | 1150000 | 0 | 0 |
| BEAM THERAPEUTICS INC | COM | 07373V105 | BBG00KXC8655 | 4358027 | 111430 | SH |  | SOLE |  | 111430 | 0 | 0 |
| BIOCRYST PHARMACEUTICALS INC | COM | 09058V103 | BBG001S7K151 | 21705661 | 1890737 | SH |  | SOLE |  | 1890737 | 0 | 0 |
| BIOHAVEN LTD | COM | G1110E107 | BBG017BXV3R8 | 9284512 | 668913 | SH |  | SOLE |  | 668913 | 0 | 0 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | BBG001S76R05 | 27373105 | 264500 | SH |  | SOLE |  | 264500 | 0 | 0 |
| BIOMEA FUSION INC | COM | 09077A106 | BBG00YS4WDD8 | 6161032 | 730846 | SH |  | SOLE |  | 730846 | 0 | 0 |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | BBG001V11BV0 | 82867053 | 1891510 | SH |  | SOLE |  | 1891510 | 0 | 0 |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | BBG001S7QN20 | 18786433 | 421504 | SH |  | SOLE |  | 421504 | 0 | 0 |
| CEREVEL THERAPEUTICS HLDNG I | COM | 15678U128 | BBG00VCYVLJ2 | 79053875 | 2506464 | SH |  | SOLE |  | 2506464 | 0 | 0 |
| CHINOOK THERAPEUTICS INC | COM | 16961L106 | BBG001T20HH5 | 13296814 | 507512 | SH |  | SOLE |  | 507512 | 0 | 0 |
| CINCOR PHARMA INC | COM | 17240Y109 | BBG00P4V66J1 | 13722744 | 1116578 | SH |  | SOLE |  | 1116578 | 0 | 0 |
| COLLEGIUM PHARMACEUTICAL INC | COM | 19459J104 | BBG001T535S9 | 16820000 | 725000 | SH |  | SOLE |  | 725000 | 0 | 0 |
| COMPASS THERAPEUTICS INC | COM | 20454B104 | BBG00LPXKF34 | 26825936 | 5333188 | SH |  | SOLE |  | 5333188 | 0 | 0 |
| COMPUGEN LTD | ORD | M25722105 | BBG001S5PQC7 | 923246 | 1289990 | SH |  | SOLE |  | 1289990 | 0 | 0 |
| CONMED CORP | COM | 207410101 | BBG001S5PZH2 | 18171200 | 205000 | SH |  | SOLE |  | 205000 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 | BBG001SGMVF2 | 20298260 | 443000 | SH |  | SOLE |  | 443000 | 0 | 0 |
| DESIGN THERAPEUTICS INC | COM | 25056L103 | BBG00SNC49W7 | 4723612 | 460391 | SH |  | SOLE |  | 460391 | 0 | 0 |
| DEXCOM INC | COM | 252131107 | BBG001SKZG99 | 55544220 | 490500 | SH |  | SOLE |  | 490500 | 0 | 0 |
| DISC MEDICINE INC | COM | 254604101 | BBG00W9MJL04 | 6752595 | 339497 | SH |  | SOLE |  | 339497 | 0 | 0 |
| DYNAVAX TECHNOLOGIES CORP | COM NEW | 268158201 | BBG001S7HTB7 | 19298385 | 1813758 | SH |  | SOLE |  | 1813758 | 0 | 0 |
| EDAP TMS S A | SPONSORED ADR | 268311107 | BBG001SB3ML7 | 9700600 | 910000 | SH |  | SOLE |  | 910000 | 0 | 0 |
| EDWARDS LIFESCIENCES CORP | COM | 28176E108 | BBG001SF2288 | 48190599 | 645900 | SH |  | SOLE |  | 645900 | 0 | 0 |
| ESSA PHARMA INC | COM NEW | 29668H708 | BBG0080GLFK7 | 1322859 | 524944 | SH |  | SOLE |  | 524944 | 0 | 0 |
| EVOLENT HEALTH INC | CL A | 30050B101 | BBG005CHLMB3 | 106802280 | 3803500 | SH |  | SOLE |  | 3803500 | 0 | 0 |
| EXACT SCIENCES CORP | COM | 30063P105 | BBG001SGCLB9 | 43940125 | 887500 | SH |  | SOLE |  | 887500 | 0 | 0 |
| FATE THERAPEUTICS INC | COM | 31189P102 | BBG001T888S2 | 1109900 | 110000 | SH |  | SOLE |  | 110000 | 0 | 0 |
| FRESHPET INC | COM | 358039105 | BBG001V04FM0 | 34669890 | 657000 | SH |  | SOLE |  | 657000 | 0 | 0 |
| F-STAR THERAPEUTICS INC | COM | 30315R107 | BBG0046HC897 | 4751938 | 751889 | SH |  | SOLE |  | 751889 | 0 | 0 |
| FULCRUM THERAPEUTICS INC | COM | 359616109 | BBG00DDY1RM7 | 2799815 | 384590 | SH |  | SOLE |  | 384590 | 0 | 0 |
| GAMIDA CELL LTD | SHS | M47364100 | BBG00M4RGJ53 | 5314649 | 4119883 | SH |  | SOLE |  | 4119883 | 0 | 0 |
| GOSSAMER BIO INC | NOTE 5.000% 6/0 | 38341PAA0 |  | 3096866 | 9573000 | PRN |  | SOLE |  | 9573000 | 0 | 0 |
| GOSSAMER BIO INC | COM | 38341P102 | BBG00MVWLMC1 | 816024 | 376048 | SH |  | SOLE |  | 376048 | 0 | 0 |
| GUARDANT HEALTH INC | COM | 40131M109 | BBG006D97VZ8 | 5440000 | 200000 | SH |  | SOLE |  | 200000 | 0 | 0 |
| HEALTH CATALYST INC | COM | 42225T107 | BBG00LDPZMT5 | 9884837 | 929900 | SH |  | SOLE |  | 929900 | 0 | 0 |
| HORIZON THERAPEUTICS PUB L | SHS | G46188101 | BBG001T9M4T2 | 84177860 | 739700 | SH |  | SOLE |  | 739700 | 0 | 0 |
| HUMANA INC | COM | 444859102 | BBG001S5S1X6 | 218449035 | 426500 | SH |  | SOLE |  | 426500 | 0 | 0 |
| ICOSAVAX INC | COM | 45114M109 | BBG00QHK2J96 | 6201140 | 781000 | SH |  | SOLE |  | 781000 | 0 | 0 |
| IDEXX LABS INC | COM | 45168D104 | BBG001S5S4Y9 | 84651700 | 207500 | SH |  | SOLE |  | 207500 | 0 | 0 |
| IMMATICS N.V | SHS | N44445109 | BBG00VTL2J09 | 19813369 | 2274784 | SH |  | SOLE |  | 2274784 | 0 | 0 |
| IMMUNOCORE HLDGS PLC | ADS | 45258D105 | BBG00YYCXG54 | 189533237 | 3321066 | SH |  | SOLE |  | 3321066 | 0 | 0 |
| INOZYME PHARMA INC | COM | 45790W108 | BBG00J7QJMD0 | 3240328 | 3086027 | SH |  | SOLE |  | 3086027 | 0 | 0 |
| INSULET CORP | COM | 45784P101 | BBG001SRF439 | 154333958 | 524250 | SH |  | SOLE |  | 524250 | 0 | 0 |
| INTUITIVE SURGICAL INC | COM NEW | 46120E602 | BBG001S7XR78 | 79206975 | 298500 | SH |  | SOLE |  | 298500 | 0 | 0 |
| INVITAE CORP | COM | 46185L103 | BBG005DJFD52 | 5761397 | 3097525 | SH |  | SOLE |  | 3097525 | 0 | 0 |
| IRHYTHM TECHNOLOGIES INC | COM | 450056106 | BBG001TSQV70 | 28986182 | 309450 | SH |  | SOLE |  | 309450 | 0 | 0 |
| KARUNA THERAPEUTICS INC | COM | 48576A100 | BBG00NN875H9 | 81304233 | 413762 | SH |  | SOLE |  | 413762 | 0 | 0 |
| KINNATE BIOPHARMA INC | COM | 49705R105 | BBG00R4SGVH0 | 4556535 | 746973 | SH |  | SOLE |  | 746973 | 0 | 0 |
| KYMERA THERAPEUTICS INC | COM | 501575104 | BBG00SDHC8F9 | 30645364 | 1227779 | SH |  | SOLE |  | 1227779 | 0 | 0 |
| LEAP THERAPEUTICS INC | COM | 52187K101 | BBG00DQ929Z3 | 1646931 | 3659847 | SH |  | SOLE |  | 3659847 | 0 | 0 |
| LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 | BBG00TTGH6N2 | 22487263 | 450466 | SH |  | SOLE |  | 450466 | 0 | 0 |
| LIFESTANCE HEALTH GROUP INC | COM | 53228F101 | BBG01138DHT2 | 13338000 | 2700000 | SH |  | SOLE |  | 2700000 | 0 | 0 |
| MACROGENICS INC | COM | 556099109 | BBG001S9C8R7 | 7535974 | 1123096 | SH |  | SOLE |  | 1123096 | 0 | 0 |
| MADRIGAL PHARMACEUTICALS INC | COM | 558868105 | BBG001SNKQ42 | 101042120 | 348121 | SH |  | SOLE |  | 348121 | 0 | 0 |
| MEREO BIOPHARMA GROUP PLC | SPON ADS | 589492107 | BBG00KFWZCX7 | 4683673 | 6244897 | SH |  | SOLE |  | 6244897 | 0 | 0 |
| MERSANA THERAPEUTICS INC | COM | 59045L106 | BBG001TZ57P0 | 24048286 | 4103803 | SH |  | SOLE |  | 4103803 | 0 | 0 |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | BBG001SF6HK7 | 36475637 | 805024 | SH |  | SOLE |  | 805024 | 0 | 0 |
| MIRUM PHARMACEUTICALS INC | COM | 604749101 | BBG00MH7T2N6 | 35016794 | 1795733 | SH |  | SOLE |  | 1795733 | 0 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | BBG001S8W4X9 | 134071400 | 1122500 | SH |  | SOLE |  | 1122500 | 0 | 0 |
| NEUROCRINE BIOSCIENCES INC | NOTE 2.250% 5/1 | 64125CAD1 |  | 1586500 | 1000000 | PRN |  | SOLE |  | 1000000 | 0 | 0 |
| NEVRO CORP | NOTE 2.750% 4/0 | 64157FAC7 |  | 458750 | 500000 | PRN |  | SOLE |  | 500000 | 0 | 0 |
| NEVRO CORP | COM | 64157F103 | BBG001V0KW81 | 42684840 | 1077900 | SH |  | SOLE |  | 1077900 | 0 | 0 |
| NKARTA INC | COM | 65487U108 | BBG00JXHS9H6 | 2356400 | 393389 | SH |  | SOLE |  | 393389 | 0 | 0 |
| NOVAVAX INC | COM NEW | 670002401 | BBG001SGL8G3 | 5475128 | 532600 | SH |  | SOLE |  | 532600 | 0 | 0 |
| NOVOCURE LTD | ORD SHS | G6674U108 | BBG009XW8QY0 | 9168750 | 125000 | SH |  | SOLE |  | 125000 | 0 | 0 |
| NUVATION BIO INC | *W EXP 07/07/202 | 67080N119 |  | 19367 | 134028 | SH |  | SOLE |  | 134028 | 0 | 0 |
| OLINK HLDG AB | SPONSORED ADS | 680710100 | BBG00ZHZXZ84 | 36674100 | 1445000 | SH |  | SOLE |  | 1445000 | 0 | 0 |
| PACIRA BIOSCIENCES INC | COM | 695127100 | BBG001S77N12 | 39868686 | 1032600 | SH |  | SOLE |  | 1032600 | 0 | 0 |
| PARATEK PHARMACEUTICALS INC | COM | 699374302 | BBG001SQHLP7 | 3242649 | 1734037 | SH |  | SOLE |  | 1734037 | 0 | 0 |
| PENUMBRA INC | COM | 70975L107 | BBG001TRHPB0 | 113065295 | 508250 | SH |  | SOLE |  | 508250 | 0 | 0 |
| PHREESIA INC | COM | 71944F106 | BBG001TG2W25 | 42148900 | 1302500 | SH |  | SOLE |  | 1302500 | 0 | 0 |
| PROMETHEUS BIOSCIENCES INC | COM | 74349U108 | BBG00PPP6G63 | 113470500 | 1031550 | SH |  | SOLE |  | 1031550 | 0 | 0 |
| PROTHENA CORP PLC | SHS | G72800108 | BBG00393H6N0 | 45396086 | 753462 | SH |  | SOLE |  | 753462 | 0 | 0 |
| PULMONX CORP | COM | 745848101 | BBG001T4HJ52 | 5499732 | 652400 | SH |  | SOLE |  | 652400 | 0 | 0 |
| RELAY THERAPEUTICS INC | COM | 75943R102 | BBG00DSS08L8 | 10069052 | 673966 | SH |  | SOLE |  | 673966 | 0 | 0 |
| RENEO PHARMACEUTICALS INC | COM | 75974E103 | BBG00JVRSRD0 | 2663621 | 1143185 | SH |  | SOLE |  | 1143185 | 0 | 0 |
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | BBG007DLZ629 | 51276389 | 1760865 | SH |  | SOLE |  | 1760865 | 0 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607100 | BBG001S6KJC6 | 56496880 | 436000 | SH |  | SOLE |  | 436000 | 0 | 0 |
| SEAGEN INC | COM | 81181C104 | BBG001S9M4Q6 | 51429702 | 400200 | SH |  | SOLE |  | 400200 | 0 | 0 |
| SELECT SECTOR SPDR TR | SBI HEALTHCARE | 81369Y209 | BBG001S7SCQ6 | 27170000 | 200000 | SH |  | SOLE |  | 200000 | 0 | 0 |
| SHOCKWAVE MED INC | COM | 82489T104 | BBG005XVXMM4 | 23665711 | 115100 | SH |  | SOLE |  | 115100 | 0 | 0 |
| SPERO THERAPEUTICS INC | COM | 84833T103 | BBG00HXSJ1S1 | 1158292 | 669533 | SH |  | SOLE |  | 669533 | 0 | 0 |
| SPRUCE BIOSCIENCES INC | COM | 85209E109 | BBG00HYZ1559 | 1780739 | 1622689 | SH |  | SOLE |  | 1622689 | 0 | 0 |
| TEMPEST THERAPEUTICS INC | COM | 87978U108 | BBG002NDK348 | 947202 | 823654 | SH |  | SOLE |  | 823654 | 0 | 0 |
| THESEUS PHARMACEUTICALS INC | COM | 88369M101 | BBG00Z0GRC64 | 2177898 | 437329 | SH |  | SOLE |  | 437329 | 0 | 0 |
| TRAVERE THERAPEUTICS INC | NOTE 2.500% 9/1 | 761299AB2 |  | 3000075 | 3250000 | PRN |  | SOLE |  | 3250000 | 0 | 0 |
| TRAVERE THERAPEUTICS INC | COM | 89422G107 | BBG001SL72C5 | 20013200 | 951650 | SH |  | SOLE |  | 951650 | 0 | 0 |
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | BBG001V2MJJ2 | 59778626 | 1290279 | SH |  | SOLE |  | 1290279 | 0 | 0 |
| UNITEDHEALTH GROUP INC | COM | 91324P102 | BBG001S6WCJ1 | 143148600 | 270000 | SH |  | SOLE |  | 270000 | 0 | 0 |
| VERVE THERAPEUTICS INC | COM | 92539P101 | BBG00P33TD13 | 10813496 | 558837 | SH |  | SOLE |  | 558837 | 0 | 0 |
| VIGIL NEUROSCIENCE INC | COM | 92673K108 | BBG00YGBK4R3 | 5899475 | 471958 | SH |  | SOLE |  | 471958 | 0 | 0 |
| VINCERX PHARMA INC | COM NEW | 92731L106 | BBG00RRQXMY1 | 909553 | 891719 | SH |  | SOLE |  | 891719 | 0 | 0 |
| WARBY PARKER INC | CL A COM | 93403J106 | BBG005DWN8L7 | 16443973 | 1218975 | SH |  | SOLE |  | 1218975 | 0 | 0 |
| WEST PHARMACEUTICAL SVSC INC | COM | 955306105 | BBG001S5XK22 | 43657425 | 185500 | SH |  | SOLE |  | 185500 | 0 | 0 |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | BBG002VBMLS5 | 46356747 | 1175672 | SH |  | SOLE |  | 1175672 | 0 | 0 |
| XILIO THERAPEUTICS INC | COM | 98422T100 | BBG00M4D4XC8 | 3666142 | 1362878 | SH |  | SOLE |  | 1362878 | 0 | 0 |
| ZAI LAB LTD | ADR | 98887Q104 | BBG00HFX3P04 | 32532790 | 1059700 | SH |  | SOLE |  | 1059700 | 0 | 0 |

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