# EDGAR Filing Document

**Accession Number:** 0001869057
**File Stem:** 0001062993-25-011153
**Filing Date:** 2025-6
**Character Count:** 11587
**Document Hash:** 8e6a0e70d53df83b429580dfabde0344
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001062993-25-011153.hdr.sgml**: 20250606

**ACCESSION NUMBER**: 0001062993-25-011153

**CONFORMED SUBMISSION TYPE**: 4

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20250604

**FILED AS OF DATE**: 20250606

**DATE AS OF CHANGE**: 20250606

**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Blue Horizon Enterprise Ltd
- **CENTRAL INDEX KEY:** 0001869057

**ORGANIZATION NAME:**
- **STATE OF INCORPORATION:** D8
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-38938
- **FILM NUMBER:** 251030975

**BUSINESS ADDRESS:**
- **STREET 1:** 3076, SIR FRANCIS DRAKES HIGHWAY
- **CITY:** ROAD TOWN, TORTOLA
- **STATE:** D8
- **ZIP:** VG1110
- **BUSINESS PHONE:** 3-572-511-0165

**MAIL ADDRESS:**
- **STREET 1:** 3076, SIR FRANCIS DRAKES HIGHWAY
- **CITY:** ROAD TOWN, TORTOLA
- **STATE:** D8
- **ZIP:** VG1110
**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Ezbon International Ltd
- **CENTRAL INDEX KEY:** 0001869027

**ORGANIZATION NAME:**
- **STATE OF INCORPORATION:** D8
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-38938
- **FILM NUMBER:** 251030974

**BUSINESS ADDRESS:**
- **STREET 1:** 3076, SIR FRANCIS DRAKES HIGHWAY
- **CITY:** ROAD TOWN, TORTOLA
- **STATE:** D8
- **ZIP:** VG1110
- **BUSINESS PHONE:** 3-572-511-0165

**MAIL ADDRESS:**
- **STREET 1:** 3076, SIR FRANCIS DRAKES HIGHWAY
- **CITY:** ROAD TOWN, TORTOLA
- **STATE:** D8
- **ZIP:** VG1110
**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Skorpios Trust
- **CENTRAL INDEX KEY:** 0001869333

**ORGANIZATION NAME:**
- **STATE OF INCORPORATION:** G4
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-38938
- **FILM NUMBER:** 251030976

**BUSINESS ADDRESS:**
- **STREET 1:** 195 ARCH. MAKARIOS III AVE.
- **STREET 2:** NEOCLEOUS HOUSE
- **CITY:** LIMASSOL
- **STATE:** G4
- **ZIP:** 3030
- **BUSINESS PHONE:** 3-572-511-0165

**MAIL ADDRESS:**
- **STREET 1:** 195 ARCH. MAKARIOS III AVE.
- **STREET 2:** NEOCLEOUS HOUSE
- **CITY:** LIMASSOL
- **STATE:** G4
- **ZIP:** 3030
**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Montrago Trustees Ltd
- **CENTRAL INDEX KEY:** 0001869331

**ORGANIZATION NAME:**
- **STATE OF INCORPORATION:** G4
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-38938
- **FILM NUMBER:** 251030973

**BUSINESS ADDRESS:**
- **STREET 1:** 195 ARCH. MAKARIOS III AVE.
- **STREET 2:** NEOCLEOUS HOUSE
- **CITY:** LIMASSOL
- **STATE:** G4
- **ZIP:** 3030
- **BUSINESS PHONE:** 3-572-511-0165

**MAIL ADDRESS:**
- **STREET 1:** 195 ARCH. MAKARIOS III AVE.
- **STREET 2:** NEOCLEOUS HOUSE
- **CITY:** LIMASSOL
- **STATE:** G4
- **ZIP:** 3030
**ISSUER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Stoke Therapeutics, Inc.
- **CENTRAL INDEX KEY:** 0001623526
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 471144582
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**BUSINESS ADDRESS:**
- **STREET 1:** 45 WIGGINS AVENUE
- **CITY:** BEDFORD
- **STATE:** MA
- **ZIP:** 01730
- **BUSINESS PHONE:** 781-430-8200

**MAIL ADDRESS:**
- **STREET 1:** 45 WIGGINS AVENUE
- **CITY:** BEDFORD
- **STATE:** MA
- **ZIP:** 01730

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ASOthera Pharmaceuticals, Inc.
- **DATE OF NAME CHANGE:** 20141028

### UNITED STATES SECURITIES AND EXCHANGE COMMISSION
**Washington, D.C. 20549**

## FORM 4

### STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

[x] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

[ ] Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Skorpios Trust<br><sub>(Last) (First) (Middle)</sub><br>195 ARCH. MAKARIOS III AVE.<br>NEOCLEOUS HOUSE<br><sub>(Street)</sub><br>LIMASSOL, G4 3030<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2025-06-04 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[ ] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>Stoke Therapeutics, Inc. [ STOK ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Blue Horizon Enterprise Ltd<br><sub>(Last) (First) (Middle)</sub><br>195 ARCH. MAKARIOS III AVE.<br>NEOCLEOUS HOUSE<br><sub>(Street)</sub><br>LIMASSOL, G4 3030<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2025-06-04 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[ ] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>Stoke Therapeutics, Inc. [ STOK ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Ezbon International Ltd<br><sub>(Last) (First) (Middle)</sub><br>195 ARCH. MAKARIOS III AVE.<br>NEOCLEOUS HOUSE<br><sub>(Street)</sub><br>LIMASSOL, G4 3030<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2025-06-04 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[ ] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>Stoke Therapeutics, Inc. [ STOK ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Montrago Trustees Ltd<br><sub>(Last) (First) (Middle)</sub><br>195 ARCH. MAKARIOS III AVE<br>NEOCLEOUS HOUSE<br><sub>(Street)</sub><br>LIMASSOL, G4 3030<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2025-06-04 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[ ] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>Stoke Therapeutics, Inc. [ STOK ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

## Table I - Non-Derivative Securities

---

|  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1. Title of Security | 2. Transaction Date | 2A. Deemed Execution Date | 3. Transaction Code (V) | 3. Transaction Code (V) | 4. Securities Acquired (A) or Disposed of (D) | 4. Securities Acquired (A) or Disposed of (D) | 4. Securities Acquired (A) or Disposed of (D) | 5. Amount of Securities Beneficially Owned | 6. Ownership Form | 7. Nature of Indirect Beneficial Ownership |
| 1. Title of Security | 2. Transaction Date | 2A. Deemed Execution Date | Code | V | Amount | (A) or (D) | Price | 5. Amount of Securities Beneficially Owned | 6. Ownership Form | 7. Nature of Indirect Beneficial Ownership |
| Common Stock | 2025-06-04 |  | S |  | 3000000 | D | $10.20 | 3906181 | I | See Footnote<sup>(1)</sup> |

---

## Table II - Derivative Securities

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1. Title of Derivative Security | 2. Conversion or Exercise Price | 3. Transaction Date | 3A. Deemed Execution Date | 4. Transaction Code (V) | 4. Transaction Code (V) | 5. Number of Derivative Securities Acquired (A) or Disposed of (D) | 5. Number of Derivative Securities Acquired (A) or Disposed of (D) | 6. Date Exercisable and Expiration Date | 6. Date Exercisable and Expiration Date | 7. Title and Amount of Underlying Securities | 7. Title and Amount of Underlying Securities | 8. Price of Derivative Security | 9. Number of Derivative Securities Beneficially Owned | 10. Ownership Form | 11. Nature of Indirect Beneficial Ownership |
| 1. Title of Derivative Security | 2. Conversion or Exercise Price | 3. Transaction Date | 3A. Deemed Execution Date | Code | V | (A) | (D) | Date Exercisable | Expiration Date | Title | Amount or Number of Shares | 8. Price of Derivative Security | 9. Number of Derivative Securities Beneficially Owned | 10. Ownership Form | 11. Nature of Indirect Beneficial Ownership |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

---

### Footnotes:

(1) Blue Horizon Enterprise Ltd. ("Blue Horizon") is the direct owner of 2,967,621 shares of the issuer's common stock and Ezbon International Limited ("Ezbon") is the direct owner of 938,560 shares of the issuer's common stock. Skorpios Trust ("Skorpios") is the sole owner of each of Blue Horizon and Ezbon. Montrago Trustees Limited ("Montrago Trustees") is the corporate trustee of Skorpios Trust. Each of Blue Horizon and Ezbon disclaim beneficial ownership of the shares of the issuer's common stock held by the other, and each of Skorpios Trust and Montrago Trustees disclaim beneficial ownership of the issuer's securities except to the extent of their pecuniary interest therein.

**Signature:** /s/ Androulla Papadopoulou, Authorized Signatory on behalf of Skorpios Trust  
**Date:** 2025-06-06

**Signature:** /s/ Eleni Constantinou Kyriacou, Authorized Signatory on behalf of Blue Horizon Enterprises Ltd.  
**Date:** 2025-06-06

**Signature:** /s/ Eleni Constantinou Kyriacou, Authorized Signatory on behalf of Ezbon International Limited  
**Date:** 2025-06-06

**Signature:** /s/ Androulla Papadopoulou, Authorized Signatory on behalf of Montrago Trustees Limited  
**Date:** 2025-06-06

### Remarks:

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

**Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.**