# EDGAR Filing Document

**Accession Number:** 0001356576
**File Stem:** 0001356576-23-000008
**Filing Date:** 2023-2
**Character Count:** 33679
**Document Hash:** cef471483f8d7453e7f6dd40c4d09557
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001356576-23-000008.hdr.sgml**: 20230228

**ACCESSION NUMBER**: 0001356576-23-000008

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 14

**CONFORMED PERIOD OF REPORT**: 20230228

**ITEM INFORMATION**: Results of Operations and Financial Condition

**FILED AS OF DATE**: 20230228

**DATE AS OF CHANGE**: 20230228

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** SUPERNUS PHARMACEUTICALS, INC.
- **CENTRAL INDEX KEY:** 0001356576
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-35518
- **FILM NUMBER:** 23686974

**BUSINESS ADDRESS:**
- **STREET 1:** 9715 KEY WEST AVENUE
- **CITY:** ROCKVILLE
- **STATE:** MD
- **ZIP:** 20850
- **BUSINESS PHONE:** 301-838-2500

**MAIL ADDRESS:**
- **STREET 1:** 9715 KEY WEST AVENUE
- **CITY:** ROCKVILLE
- **STATE:** MD
- **ZIP:** 20850

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** SUPERNUS PHARMACEUTICALS INC
- **DATE OF NAME CHANGE:** 20060317

?xml version="1.0" ? supn-20230228

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**FORM 8-K** 

**CURRENT REPORT**

**Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934**

Date of Report (Date of earliest event reported): **February 28, 2023** 

**Supernus Pharmaceuticals, Inc.** 

(Exact name of registrant as specified in its charter)

---

| | | | |
|:---|:---|:---|:---|
| **Delaware** | **001-35518** | **001-35518** | **20-2590184** |
| (State or other jurisdiction of incorporation or organization) | (Commission File Number) | (Commission File Number) | (I.R.S. Employer Identification No.) |
| **9715 Key West Ave** | **Rockville** | **MD** | **20850** |
| (Address of Principal Executive Offices) | | | (Zip Code) |

---

Registrant's telephone number, including area code: **(301) 838-2500** 

**Not Applicable**

(Former name or former address, if changed since last report.)

&nbsp;&nbsp;&nbsp;&nbsp;Securities registered pursuant to Section 12(b) of the Exchange Act

---

| | | |
|:---|:---|:---|
| <u>Title of each class</u> | <u>Trading Symbol</u> | <u>Name of each exchange on which registered</u> |
| Common Stock, $0.001 par value per share | SUPN | The Nasdaq Stock Market LLC |

---

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (<u>see</u> General Instruction A.2. below):

☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter). ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

------

**Item 2.02**&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Results of Operations and Financial Condition.**

On February 28, 2023, Supernus Pharmaceuticals, Inc. ("Supernus" or the "Company") issued a press release regarding its financial results for the fourth quarter and full year ended December 31, 2022. A copy of this press release is furnished as Exhibit 99.1 hereto and is incorporated herein by reference.

As previously announced, Supernus is hosting a conference call at 4:30 p.m. Eastern Time on Tuesday, February 28, 2023, to present the business and financial results. A live webcast is available at <u>www.supernus.com</u>. The webcast will be archived on the Company's website for 60 days following the live call.

The information in this Item 2.02 (including Exhibit 99.1) is being "furnished" and shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, whether made before or after the date of this report, except as shall be expressly set forth by specific reference in such filing.

This Current Report on Form 8-K contains "forward-looking statements" that do not convey historical information, but relate to predicted or potential future events, such as statements of our plans, strategies and intentions. These statements can often be identified by the use of forward-looking terminology such as "believe," "expect," "intend," "may," "will," "should," or "anticipate" or similar terminology. All statements other than statements of historical facts included in this Current Report on Form 8-K are forward-looking statements. All forward-looking statements speak only as of the date of this Current Report on Form 8-K. Except for Supernus' ongoing obligations to disclose material information under the federal securities laws, Supernus undertakes no obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise. In addition to the risks and uncertainties of ordinary business operations and conditions in the general economy and the markets in which Supernus competes, the forward-looking statements of Supernus contained in this Current Report on Form 8-K are also subject to various risks and uncertainties, including those set forth in Item 1A, "Risk Factors," in Supernus' Annual Report on Form 10-K for the fiscal year ended December 31, 2021 which the Company filed on April 13, 2022, and other risk factors set forth from time to time in the Company's filings with the Securities and Exchange Commission made pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934, as amended.

**Item 9.01**&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Financial Statements and Exhibits\*.**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Exhibits

Exhibit 99.1 —<u>[Press Release Dated February 28, 2023](ex99102-28x2023.htm)</u> furnished as an Exhibit pursuant to Item 2.02 hereof.

Exhibit 104 — The cover page from this Current Report on Form 8-K, formatted in Inline XBRL.

______________________________________

**\*** The information furnished under Item 2.02 and Item 9.01 of this Current Report on Form 8-K, including the exhibits, shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange act of 1934, as amended, or otherwise subject to liabilities under that section, nor shall it be deemed incorporated by reference in any registration statement or other filings of the Company under the Securities act of 1933, as amended, except as shall be set forth by specific reference in such filing.

------

**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

---

| | | |
|:---|:---|:---|
| | SUPERNUS PHARMACEUTICALS, INC. | SUPERNUS PHARMACEUTICALS, INC. |
| DATED: February 28, 2023 | By: | /s/ Timothy Dec |
|  |  | Timothy Dec |
|  |  | Senior Vice-President and Chief Financial Officer |

---

## Exhibit 99.1

**Exhibit 99.1**

![supernuslogo.jpg](supernuslogo.jpg)

**Supernus Announces Fourth Quarter and Full Year 2022 Financial Results**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Full Year 2022 total revenues of $667.2 million, a 15% increase compared to full year 2021

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Fourth quarter 2022 Qelbree<sup>®</sup> net product sales of $23.6 million increased 29% compared to third quarter of 2022; Full year 2022 Qelbree net product sales of $61.3 million, compared to $9.9 million for full year 2021

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Executed a second significant pharmacy benefit manager contract for Qelbree

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Fourth quarter 2022 GOCOVRI® net product sales of $29.2 million increased 13% compared to fourth quarter of 2021; Full year 2022 GOCOVRI net product sales of $104.4 million increased 19% compared to full year 2021<sup>1</sup>

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Anticipates approximately 30% growth at the midpoint of full year 2023 total revenues guidance compared to full year 2022, excluding revenues of Trokendi XR<sup>®</sup>

<sup>1</sup>*Includes net product sales reported by Adamas Pharmaceuticals prior to the acquisition of Adamas by Supernus Pharmaceuticals in November 2021.*

**ROCKVILLE, MD, February 28, 2023** – Supernus Pharmaceuticals, Inc. (Nasdaq: SUPN), a biopharmaceutical company focused on developing and commercializing products for the treatment of central nervous system (CNS) diseases, today announced financial results for the fourth quarter and full year of 2022 and associated Company developments.

"In 2022, we continued to execute on our long-term growth strategy focusing on successfully transitioning from our legacy and mature products to our growth products, and finished the year with record revenues of $667.2 million, up 15% from the prior year," said Jack Khattar, President and CEO of Supernus. "Based on this successful transition and with a solid foundation, we are confident that our growth drivers will allow us to offset the impact coming from loss of exclusivity for Trokendi XR and position us well to drive strong revenue and non-GAAP operating income growth in 2024 and beyond."

**Qelbree Update**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Total IQVIA prescriptions were 117,635 in the fourth quarter of 2022, an increase of 24% compared to total prescriptions of 94,681 in the third quarter of 2022. In January 2023, the most recent month available, total prescriptions reached 42,881.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Continued healthy growth in the U.S. attention-deficit hyperactivity disorder market with 2022 total number of prescriptions reaching more than 90 million, an increase of 9% compared to 2021, according to IQVIA.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• The average wholesale acquisition cost per Qelbree prescription continued to increase in the fourth quarter of 2022, driven by increases in the average daily dose and prescription size.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Executed a second significant pharmacy benefit manager contract effective January 2023, and continued making progress in securing and improving managed care coverage.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Qelbree continues to expand its base of prescribers, with approximately 16,822 prescribers in the fourth quarter of 2022, up from 14,265 prescribers from the third quarter of 2022.

**Product Pipeline Update**

*SPN-830 (apomorphine infusion device) - Continuous treatment of motor fluctuations ("off" episodes) in Parkinson's disease (PD)*

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• The Company will be meeting with the U.S. Food and Drug Administration (FDA) in April 2023 to discuss the Complete Response Letter received in October 2022. We will announce the timing for our resubmission after our discussion with the FDA.

------

*SPN-820 - Novel first-in-class activator of mTORC1*

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• The Phase II multi-center, randomized double-blind placebo-controlled parallel design study of SPN-820 in adults with treatment-resistant depression is ongoing. The study will examine the efficacy and safety of SPN-820 over a course of five weeks of treatment in approximately 270 patients. The primary outcome measure is the change from baseline to end of treatment period on the Montgomery-Asberg Depression Rating Scale (MADRS) Total Score, a standard depression rating scale.

*SPN-817 – A novel product candidate for the treatment of epilepsy*

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• The Company has commenced an open-label Phase II clinical study of SPN-817 in patients with treatment-resistant seizures. Depending on the rate of enrollment, the Company expects to have data in the first half of 2024.

**Financial Highlights**

***Net Product Sales***

For the three months ended December 31, 2022, net product sales were $163.8 million, a 6% increase over net product sales of $155.0 million for the same period in 2021. For the full year ended December 31, 2022, net product sales were $649.4 million, a 14% increase over net product sales of $567.5 million for the same period in 2021. The increases in both periods were primarily due to net product sales of GOCOVRI and growth in net product sales of Qelbree.

The following table provides information regarding net product sales during the three months and full year ended December 31, 2022 and 2021 (dollars in millions):

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| | **Three Months Ended<br>December 31,** | **Three Months Ended<br>December 31,** | | **Full Year Ended<br>December 31,** | **Full Year Ended<br>December 31,** | |
| | **2022** | **2021** | **Change %** | **2022** | **2021** | **Change %** |
| Net product sales |  |  |  |  |  |  |
| &nbsp;&nbsp;Trokendi XR<sup>®</sup> | $57.2 | $73.3 | (22)% | $261.2 | $304.8 | (14)% |
| &nbsp;&nbsp;Oxtellar XR<sup>®</sup> | 27.4 | 28.6 | (4)% | 115.4 | 110.7 | 4% |
| &nbsp;&nbsp;GOCOVRI<sup>(1)</sup> | 29.2 | 9.8 | \*\* | 104.4 | 9.8 | \*\* |
| &nbsp;&nbsp;&nbsp;Qelbree | 23.6 | 7.2 | 228% | 61.3 | 9.9 | 519% |
| &nbsp;&nbsp;APOKYN<sup>®</sup> | 18.1 | 25.9 | (30)% | 75.3 | 99.2 | (24)% |
| &nbsp;&nbsp;Other<sup>(2)</sup> | 8.3 | 10.2 | (19)% | 31.8 | 33.1 | (4)% |
| Total net product sales | $163.8 | $155.0 | 6% | $649.4 | $567.5 | 14% |

---

___________________________________________

&nbsp;&nbsp;&nbsp;&nbsp;<sup>(1)</sup> Net product sales as of the acquisition of Adamas Pharmaceuticals, Inc. by the Company (the "Adamas Acquisition") in November 2021.

&nbsp;&nbsp;&nbsp;&nbsp;<sup>(2)</sup> Includes net product sales of MYOBLOC<sup>®</sup>, XADAGO<sup>®</sup> and Osmolex ER<sup>®</sup>.

\*\* Percentage not meaningful for comparative purposes since net product sales for 2021 included revenues from date of Adamas Acquisition.

***Operating earnings (GAAP and non-GAAP)***

For the three months ended December 31, 2022, operating earnings (GAAP) was $34.3 million, as compared to operating earnings (GAAP) of $6.1 million for the same period in 2021. The increase was primarily due to full quarter net product sales of the commercial products acquired through the Adamas Acquisition and decreased selling, general and administrative expense due to the Adamas Acquisition-related costs incurred in 2021. For the full year ended December 31, 2022 operating earnings (GAAP) were $46.1 million, as compared to $86.0 million for the same period in 2021. The decrease was primarily due to activities to support the launch of Qelbree to the adult population and amortization of acquired intangible assets from the Adamas Acquisition.

For the three months ended December 31, 2022, adjusted operating earnings (non-GAAP) were $57.6 million, compared to $46.2 million in the fourth quarter of 2021. For the full year ended December 31, 2022, adjusted operating earnings (non-GAAP) were $148.8 million, compared to $167.3 million for the same period of 2021.

------

**Reconciliation of GAAP to Non-GAAP Adjustments** 

An itemized reconciliation between operating earnings on a GAAP basis and operating earnings on a non-GAAP basis is as follows (dollars in millions):

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended<br>December 31,** | **Three Months Ended<br>December 31,** | **Full Year Ended<br>December 31,** | **Full Year Ended<br>December 31,** |
| | **2022** | **2021** | **2022** | **2021** |
| **Operating earnings - As Reported (GAAP)** | $34.3 | $6.1 | $46.1 | $86.0 |
| &nbsp;&nbsp;&nbsp;&nbsp;Adjustments: |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Amortization of intangible assets | 20.7 | 12.0 | 82.6 | 30.0 |
| &nbsp;&nbsp;&nbsp;&nbsp;Share-based compensation | 4.3 | 4.0 | 17.6 | 17.9 |
| &nbsp;&nbsp;&nbsp;&nbsp;Contingent consideration expense (gain) | (2.4) | 1.1 | (0.5) | (6.5) |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition-related costs |  | 22.3 |  | 22.3 |
| &nbsp;&nbsp;&nbsp;&nbsp;Other R&D |  |  |  | 15.0 |
| &nbsp;&nbsp;&nbsp;&nbsp;Depreciation | 0.7 | 0.7 | 3.0 | 2.6 |
| **Operating earnings - As Adjusted (non-GAAP)** | $57.6 | $46.2 | $148.8 | $167.3 |

---

Non-GAAP operating earnings adjusts for non-cash items including amortization of intangible assets, share-based compensation expense, change in fair value of contingent consideration, depreciation, and non-recurring costs. Acquisition-related costs reflect non-recurring acquisition-related costs associated with the Adamas Acquisition. Other R&D reflects a non-cash expense related to the equity investment in Navitor due to the accounting impact of the March 2021 Navitor corporate restructuring. The increase in amortization of intangible assets for the three and twelve month periods ended December 31, 2022 was due to the amortization of acquired intangible assets from the Adamas Acquisition in November 2021.

***Net earnings (GAAP)***

For the three months ended December 31, 2022, net earnings (GAAP) and diluted earnings per share (GAAP) were $25.5 million and $0.43, respectively, as compared to $2.4 million, or $0.04 per diluted share, in the same period in 2021.

For the full year ended December 31, 2022, net earnings (GAAP) and diluted earnings per share (GAAP) were $60.7 million and $1.04, respectively, as compared to $53.4 million, or $0.98 per diluted share, in the same period in 2021.

***Balance sheet***

At December 31, 2022, the Company's cash, cash equivalents, current and long-term marketable securities are approximately $555.2 million, compared to $458.8 million as of December 31, 2021. This increase was primarily due to cash generated from operations.

In February 2023, the Company entered into a credit line agreement with UBS Bank USA providing the Company an uncommitted demand secured line of credit of up to $150.0 million, which can be drawn at any time.

**Full Year 2023 Financial Guidance (GAAP)**

The Company's full year 2023 total revenue guidance represents approximately 30% growth at the midpoint compared to full year 2022, excluding revenues of Trokendi XR in both periods. The Company's full-year 2023 financial guidance is set forth below (dollars in millions):

---

| | |
|:---|:---|
| | **Amount** |
| Total revenues <sup>(1)</sup> (*Includes $60 million to $80 million of Trokendi XR*<sup>(2)</sup>*)* | $580 - $620 |
| Combined R&D and SG&A expenses | $460 - $490 |
| Operating loss <sup>(3)</sup> | $(50) - $(25) |

---

___________________________________________

&nbsp;&nbsp;&nbsp;&nbsp;<sup>(1)</sup> Includes net product sales and royalty revenue.

&nbsp;&nbsp;&nbsp;&nbsp;<sup>(2)</sup> Reflects generic entry on Trokendi XR in 2023.

&nbsp;&nbsp;&nbsp;&nbsp;<sup>(3)</sup> Includes amortization of intangible assets and contingent consideration expense (gain).

------

**Full Year 2023 Financial Guidance - GAAP to Non-GAAP Adjustments**

An itemized reconciliation between projected operating loss on a GAAP basis and projected operating earnings on a non-GAAP basis is as follows (dollars in millions):

---

| | |
|:---|:---|
| | **Amount** |
| **Operating loss - GAAP** | $(50) - $(25) |
| &nbsp;&nbsp;&nbsp;Adjustments: |  |
| &nbsp;&nbsp;&nbsp;Amortization of intangible assets | $80 - $80 |
| &nbsp;&nbsp;&nbsp;Share-based compensation | $20 - $23 |
| &nbsp;&nbsp;&nbsp;Contingent consideration | $10 - $12 |
| &nbsp;&nbsp;&nbsp;Depreciation | $5 - $5 |
| **Operating earnings - non-GAAP** | $65 - $95 |

---

**Non-GAAP Financial Information**

This press release contains a financial measure, non-GAAP operating earnings, which does not comply with United States generally accepted accounting principles (GAAP). The non-GAAP financial measure should be considered in addition to, not as a substitute for or in isolation from, or superior to measures prepared in accordance with GAAP. Non-GAAP operating earnings adjusts for non-cash share-based compensation expense, depreciation and amortization, and accretion of contingent consideration, and for factors that are unusual, non-recurring or unpredictable, and excludes those costs, expenses, and other specified items presented in the reconciliation tables in this press release. We believe the use of non-GAAP operating earnings is useful supplemental information to investors regarding the Company's results of operations and assist management, analysts, and investors in evaluating the performance of the business. There are limitations associated with the use of non-GAAP financial measures. Including such measures may not be entirely comparable to similarly titled measures used by other companies, may not reflect all items of income and expense, as applicable, that affect our operations, potential differences among calculation methodologies, may differ from the non-GAAP information used by other companies, including peer companies, and therefore comparability may be limited. We mitigate these limitations by reconciling the non-GAAP financial measure to the most comparable GAAP financial measure. Investors are encouraged to review the reconciliation. The Company's financial guidance is also being provided on both a reported and a non-GAAP basis.

**Conference Call Details**

Supernus will host a conference call and webcast today, February 28, 2023, at 4:30 p.m. Eastern Time to discuss these results.

A live webcast will be available in the Events & Presentations section of the Company's Investor Relations website www.supernus.com/investors.

Participants may also pre-register any time before the call here. Once registration is completed, participants will be provided a dial-in number with a personalized conference code to access the call. Please dial in 15 minutes prior to the start time.

Following the live call, a replay will be available on the Company's Investor Relations website www.supernus.com/investors. The webcast will be available on the Company's website for 60 days following the live call.

**About Supernus Pharmaceuticals, Inc.**

Supernus Pharmaceuticals is a biopharmaceutical company focused on developing and commercializing products for the treatment of central nervous system (CNS) diseases.

Our diverse neuroscience portfolio includes approved treatments for epilepsy, migraine, ADHD, hypomobility in PD, cervical dystonia, chronic sialorrhea, dyskinesia in PD patients receiving levodopa-based therapy, and drug-induced extrapyramidal reactions in adult patients. We are developing a broad range of novel CNS product candidates including new potential treatments for hypomobility in PD, epilepsy, depression, and other CNS disorders.

For more information, please visit <u>www.supernus.com</u>.

------

**Forward-Looking Statements**

This press release includes forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These statements do not convey historical information but relate to predicted or potential future events that are based upon management's current expectations. These statements are subject to risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. In addition to the factors mentioned in this press release, such risks and uncertainties include, but are not limited to, the Company's ability to sustain and increase its profitability; the Company's ability to raise sufficient capital to fully implement its corporate strategy; the implementation of the Company's corporate strategy; the Company's future financial performance and projected expenditures; the Company's ability to increase the number of prescriptions written for each of its products and the products of its subsidiaries; the Company's ability to increase its net revenue; the Company's ability to commercialize its products and the products of its subsidiaries; the Company's ability to enter into future collaborations with pharmaceutical companies and academic institutions or to obtain funding from government agencies; the Company's product research and development activities, including the timing and progress of the Company's clinical trials, and projected expenditures; the Company's ability to receive, and the timing of any receipt of, regulatory approvals to develop and commercialize the Company's product candidates; the Company's ability to protect its intellectual property and the intellectual property of its subsidiaries and operate its business without infringing upon the intellectual property rights of others; the Company's expectations regarding federal, state and foreign regulatory requirements; the therapeutic benefits, effectiveness and safety of the Company's product candidates; the accuracy of the Company's estimates of the size and characteristics of the markets that may be addressed by its product candidates; the Company's ability to increase its manufacturing capabilities for its products and product candidates; the Company's projected markets and growth in markets; the Company's product formulations and patient needs and potential funding sources; the Company's staffing needs; the Company's ability to increase the number of prescriptions written for each of its products and the products of its subsidiaries; the Company's ability to increase its net revenue from its products and the products of its subsidiaries; and other risk factors set forth from time to time in the Company's filings with the Securities and Exchange Commission made pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934, as amended. The Company undertakes no obligation to update the information in this press release to reflect events or circumstances after the date hereof or to reflect the occurrence of anticipated or unanticipated events.

------

**Supernus Pharmaceuticals, Inc.**

**Consolidated Balance Sheets**

**(in thousands, except share data)**

---

| | | |
|:---|:---|:---|
| | **December 31,**<br>**2022** | **December 31,**<br>**2021** |
| | **(Unaudited)** | |
| **Assets** |  |  |
| Current assets |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Cash and cash equivalents | $93120 | $203434 |
| &nbsp;&nbsp;&nbsp;&nbsp;Marketable securities | 368214 | 136246 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accounts receivable, net | 165497 | 148932 |
| &nbsp;&nbsp;&nbsp;&nbsp;Inventories, net | 91541 | 85959 |
| &nbsp;&nbsp;&nbsp;&nbsp;Prepaid expenses and other current assets | 15779 | 27019 |
| **Total current assets** | 734151 | 601590 |
| &nbsp;&nbsp;&nbsp;&nbsp;Long-term marketable securities | 93896 | 119166 |
| &nbsp;&nbsp;&nbsp;&nbsp;Property and equipment, net | 15173 | 16955 |
| &nbsp;&nbsp;&nbsp;&nbsp;Intangible assets, net | 702463 | 784693 |
| &nbsp;&nbsp;&nbsp;&nbsp;Goodwill | 117019 | 117516 |
| &nbsp;&nbsp;&nbsp;&nbsp;Other assets | 39806 | 49232 |
| **Total assets** | $1702508 | $1689152 |
| **Liabilities and stockholders' equity** |  |  |
| Current liabilities |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Accounts payable and accrued liabilities | $96342 | $117683 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accrued product returns and rebates | 151665 | 132724 |
| &nbsp;&nbsp;&nbsp;&nbsp;Contingent consideration, current portion | 21120 | 44840 |
| &nbsp;&nbsp;&nbsp;&nbsp;Convertible notes, net <sup>(a)</sup> | 401968 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Other current liabilities | 16863 | 20132 |
| **Total current liabilities** | 687958 | 315379 |
| &nbsp;&nbsp;&nbsp;&nbsp;Convertible notes, net <sup>(a)</sup> |  | 379252 |
| &nbsp;&nbsp;&nbsp;&nbsp;Contingent consideration, long-term | 33847 | 35637 |
| &nbsp;&nbsp;&nbsp;&nbsp;Operating lease liabilities, long-term | 35998 | 41298 |
| &nbsp;&nbsp;&nbsp;&nbsp;Deferred income tax liabilities <sup>(a)</sup> | 49809 | 85355 |
| &nbsp;&nbsp;&nbsp;&nbsp;Other liabilities | 8692 | 16380 |
| **Total liabilities** | 816304 | 873301 |
| **Stockholders' equity** |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Common stock, $0.001 par value; 130,000,000 shares authorized; 54,253,796 and 53,256,094 shares issued and outstanding as of December 31, 2022 and December 31, 2021, respectively | 54 | 53 |
| &nbsp;&nbsp;&nbsp;&nbsp;Additional paid-in capital <sup>(a)</sup> | 408115 | 434337 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accumulated other comprehensive (loss) earnings, net of tax | (3210) | 1539 |
| &nbsp;&nbsp;&nbsp;&nbsp;Retained earnings <sup>(a)</sup> | 481245 | 379922 |
| **Total stockholders' equity** | 886204 | 815851 |
| **Total liabilities and stockholders' equity** | $1702508 | $1689152 |

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______________________________

<sup>(a)</sup> Effective January 1, 2022, the Company adopted the simplified convertible instruments accounting guidance (ASU 2020-06), which impacted the treatment of our Convertible Senior Notes Due 2023. The adoption of ASU 2020-06 increased the carrying amount of the convertible notes, net by $20.6 million, increased retained earnings by $40.6 million, reduced additional paid-in capital by $56.2 million, and decreased deferred tax liabilities by $5.0 million as of January 1, 2022.

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**Supernus Pharmaceuticals, Inc.**

**Consolidated Statements of Earnings**

**(in thousands, except share and per share data)**

**(Unaudited)**

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| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended<br>December 31,** | **Three Months Ended<br>December 31,** | **Twelve Months Ended<br>December 31,** | **Twelve Months Ended<br>December 31,** |
| | **2022** | **2021** | **2022** | **2021** |
| Revenues |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Net product sales | $163785 | $154963 | $649432 | $567504 |
| &nbsp;&nbsp;&nbsp;&nbsp;Royalty revenues | 3543 | 4087 | 17806 | 12271 |
| &nbsp;&nbsp;Total revenues | 167328 | 159050 | 667238 | 579775 |
| Costs and expenses |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Cost of goods sold <sup>(a)</sup> | 22954 | 16994 | 87221 | 75061 |
| &nbsp;&nbsp;&nbsp;&nbsp;Research and development | 17774 | 21078 | 74552 | 90467 |
| &nbsp;&nbsp;&nbsp;&nbsp;Selling, general and administrative | 73972 | 101735 | 377221 | 304759 |
| &nbsp;&nbsp;&nbsp;&nbsp;Amortization of intangible assets | 20698 | 12025 | 82630 | 29989 |
| &nbsp;&nbsp;&nbsp;&nbsp;Contingent consideration (gain) expense | (2404) | 1120 | (510) | (6530) |
| &nbsp;&nbsp;&nbsp;Total costs and expenses | 132994 | 152952 | 621114 | 493746 |
| Operating earnings | 34334 | 6098 | 46124 | 86029 |
| Other income (expense) |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Interest and other income, net | 2400 | 1887 | 21689 | 10569 |
| &nbsp;&nbsp;&nbsp;&nbsp;Interest expense <sup>(b)</sup> | (1594) | (5934) | (7070) | (23423) |
| Total other income (expense) | 806 | (4047) | 14619 | (12854) |
| Earnings before income taxes | 35140 | 2051 | 60743 | 73175 |
| Income tax (benefit) expense | 9659 | (391) | 32 | 19751 |
| Net earnings | $25481 | $2442 | $60711 | $53424 |
| Earnings per share |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Basic | $0.47 | $0.05 | $1.13 | $1.01 |
| &nbsp;&nbsp;Diluted <sup>(b)</sup> | $0.43 | $0.04 | $1.04 | $0.98 |
| Weighted average shares outstanding |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Basic | 54104908 | 53235082 | 53665143 | 53099330 |
| &nbsp;&nbsp;Diluted <sup>(b)</sup> | 62087687 | 54528826 | 61679800 | 54356744 |

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______________________________

<sup>(a)</sup> Excludes amortization of acquired intangible assets

<sup>(b)</sup> As a result of the adoption of ASU 2020-06 in January 1, 2022, for the 2022 periods presented, the Company used the if-converted method in calculating diluted earnings per share. The potential dilutive effect of the convertible notes, an increase of 6.8 million in dilutive shares, is included in the computation of diluted earnings (loss) per share if these are determined to be dilutive for the respective period. In addition, beginning January 1, 2022, the Company no longer records interest expense on the previously recorded discount for the embedded conversion feature on the Convertible Senior Notes Due 2023.

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**CONTACTS:**

Jack A. Khattar, President and CEO

Timothy C. Dec, Senior Vice President and CFO

Supernus Pharmaceuticals, Inc.

Tel: (301) 838-2591

or

INVESTOR CONTACT:

Peter Vozzo

ICR Westwicke

Office: (443) 213-0505

Mobile: (443) 377-4767

Email: peter.vozzo@westwicke.com

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