# EDGAR Filing Document

**Accession Number:** 0000874015
**File Stem:** 0000874015-26-000021
**Filing Date:** 2026-1
**Character Count:** 10620
**Document Hash:** 73a1e396f4bb2e943ba1c73cf62d8589
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000874015-26-000021.hdr.sgml**: 20260106

**ACCESSION NUMBER**: 0000874015-26-000021

**CONFORMED SUBMISSION TYPE**: 3

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20251221

**FILED AS OF DATE**: 20260106

**DATE AS OF CHANGE**: 20260106

**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Kordasiewicz Holly B.
- **CENTRAL INDEX KEY:** 0002102721

**ORGANIZATION NAME:**

**FILING VALUES:**
- **FORM TYPE:** 3
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 000-19125
- **FILM NUMBER:** 26512926

**MAIL ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** C/O IONIS PHARMACEUTICALS, INC.
- **STREET 2:** 2855 GAZELLE COURT
- **CITY:** CARLSBAD
- **NON US STATE TERRITORY:** CA
- **PROVINCE COUNTRY:** X1
- **ZIP:** 92010
**ISSUER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** IONIS PHARMACEUTICALS INC
- **CENTRAL INDEX KEY:** 0000874015
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 330336973
- **STATE OF INCORPORATION:** CA
- **FISCAL YEAR END:** 1231

**BUSINESS ADDRESS:**
- **STREET 1:** 2855 GAZELLE COURT
- **CITY:** CARLSBAD
- **STATE:** CA
- **ZIP:** 92010
- **BUSINESS PHONE:** 7609319200

**MAIL ADDRESS:**
- **STREET 1:** 2855 GAZELLE COURT
- **CITY:** CARLSBAD
- **STATE:** CA
- **ZIP:** 92010

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ISIS PHARMACEUTICALS INC
- **DATE OF NAME CHANGE:** 19930328

## Ex-24

```

POWER OF ATTORNEY
Know all by these presents, that the undersigned hereby constitutes
and appoints each of BRETT MONIA and PATRICKR. O'NEIL, signing individually,
the undersigned's true and lawful attorneys-in fact and agents to:
(1)
execute for and on behalf of the undersigned, an officer, director or holder
of 10% or more of a registered class of securities of Ionis Pharmaceuticals,
Inc. ("Ionis"), Forms 3, 4, 5 and 144 paperwork in accordance with Section
16(a) of the Securities Exchange Act of 1934, as amended (the "Exchange Act")
and the rules thereunder;

(2)
do and perform any and all acts for and on behalf of the undersigned that
may be necessary or desirable to complete and execute such Form 3, 4, 5, and
144 paperwork complete and execute any amendment or amendments thereto, and
timely file such forms or amendments with the United States Securities and
Exchange Commission and any stock exchange or similar authority; and

(3)
take any other action of any nature whatsoever in connection with the
foregoing which, in the opinion of such attorney-in-fact, may be of benefit,
in the best interest of, or legally required by, the undersigned, it being
understood that the documents executed by such attorney-in-fact on behalf
of the undersigned pursuant to this Power of Attorney shall be in such
form and shall contain such terms and conditions as such attorney-in-fact
may approve in such attorney-in-fact's discretion.

The undersigned hereby grants to each such attorney-in-fact full power and
authority to do and perform any and every act and thing whatsoever requisite,
necessary, or proper to be done in the exercise of any of the rights and powers
herein granted, as fully to all intents and purposes as the undersigned might
or could do if personally present, with full power of substitution or
revocation,hereby ratifying and confirming all that such attorney-infact,
or such attorney-in-fact's substitute or substitutes, will lawfully do or
cause to be done by virtue of this power of attorney and the
rights and powers herein granted. The undersigned acknowledges that
the foregoing attorneysin-fact, in serving in such capacity at the request
of the undersigned,are not assuming, nor is Ionis assuming, any of the
undersigned's responsibilities to comply with Section 16 of the Exchange
Act. This Power of Attorney shall remain in full force and
effect until the earliest to occur of (a) the undersigned is no longer
required to file Forms 3, 4, 5 and 144 paperwork with respect to the
undersigned's holdings  of and transactions in securities issued by Ionis,
(b) revocation by the  undersigned in a signed writing delivered
to the foregoing attorneys-in-fact or (c) as to any attorney-in-fact
individually, until such attorney-in-fact will no longer be employed
by Ionis. IN WITNESS WHEREOF, the undersigned has caused this Power
of Attorney to be executed as of this 6th day of January 2026.
Signed: � Date: \ / (a /"J. (o
-------"---'-------

�OLLKoA
CALIFORNIA ACKNOWLEDGMENT CIVIL CODE § 1189
A notary public or other officer completing this certificate verifies
only the identity of the individual who signed the document to which
this certificate is attached, and not the truthfulness, accuracy,
or validity of that document.

who proved to me on the basis of satisfactory evidence to be the
person(s) whose name(s) is/are subscribed to the within instrument
and acknowledged to me that he/she/they
executed the same in his/her/their authorized capacity(ies), and
that by his/her/their signature(s) on the instrument the person(s),
or the entity upon behalf of which the person(s)
acted, executed the instrument.
I certify under PENAL TY OF PERJURY under the

�--·······
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laws of the State of California that the foregoing
PAMELA GROOMS
para_graph is true and correct.
----;. ·-; '"'". """''' :
i .., San Dlf!IO County s:
Commission # 2420771 t WITNESS my hand and official seal.

�!,Y com , Expires�J2, 202�
i =

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Place Notary Seal and/or Stamp Above Signature of Notary Public

OPTIONAL
Completing this information can deter alteration of the document
or fraudulent reattachment of this form to an unintended document.

Description of Attached Do�ent
l'
Title or Type of Document: �v-J'eV �� Afuen<._j
Number of Pages: --+1 __
-·
Signer(s) Other Than Named Above: ________________________

Capacity(ies) Claimed by Signer(s)
Signer's Name: ___________ _ Signer's Name: ____________
□
Corporate Officer -Title(s): _______ o Corporate Officer -Title(s): _______

□
Partner -□ Limited □ General o Partner -□
Limited □ General

□
Individual □ Attorney in Fact □ Individual □
Attorney in Fact

□
Trustee o Guardian or Conservator □ Trustee □
Guardian or Conservator D Other: ---------------D Other:

Signer is Representing: _________ Signer is Representing: _________
©2019 National Notary Association

```

### UNITED STATES SECURITIES AND EXCHANGE COMMISSION
**Washington, D.C. 20549**

## FORM 3

### INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Kordasiewicz Holly B.<br><sub>(Last) (First) (Middle)</sub><br>2855 GAZELLE COURT<br><sub>(Street)</sub><br>CARLSBAD, CA 92010<br><sub>(City) (State) (Zip)</sub> | **3. Issuer Name and Ticker or Trading Symbol**<br>IONIS PHARMACEUTICALS INC [ IONS ] | **5. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  |
| **2. Date of Event Requiring Statement (Month/Day/Year)**<br>2025-12-21 | **4. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[ ] Director   [ ] 10% Owner<br>[X] Officer (give title below)   [ ] Other (specify below)<br>_EVP, Chief Development Officer_ | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[X] Form filed by One Reporting Person<br>[ ] Form filed by More than One Reporting Person |

---

## Table I - Non-Derivative Securities Beneficially Owned

---

|  |  |  |  |
| --- | --- | --- | --- |
| 1. Title of Security | 2. Amount of Securities Beneficially Owned | 3. Ownership Form | 4. Nature of Indirect Beneficial Ownership |
| Common Stock | 7740 | D |  |

---

## Table II - Derivative Securities Beneficially Owned

---

|  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- |
| 1. Title of Derivative Security | 2. Date Exercisable and Expiration Date (Month/Day/Year) | 2. Date Exercisable and Expiration Date (Month/Day/Year) | 3. Title and Amount of Underlying Securities | 3. Title and Amount of Underlying Securities | 4. Conversion or Exercise Price | 5. Ownership Form | 6. Nature of Indirect Beneficial Ownership |
| 1. Title of Derivative Security | Date Exercisable | Expiration Date | Title | Amount or Number of Shares | 4. Conversion or Exercise Price | 5. Ownership Form | 6. Nature of Indirect Beneficial Ownership |
| Non-Qualified Stock Option (right to buy) | 2023-01-03 | 2032-01-02 | Common Stock | 12000 | $32.6 | D |  |
| Non-Qualified Stock Option (right to buy) | 2026-01-02 | 2035-01-01 | Common Stock | 10000 | $34.69 | D |  |
| Non-Qualified Stock Option (right to buy) | 2024-01-03 | 2033-01-02 | Common Stock | 11500 | $37.58 | D |  |
| Non-Qualified Stock Option (right to buy) | 2025-01-02 | 2034-01-01 | Common Stock | 19800 | $52.87 | D |  |
| Non-Qualified Stock Option (right to buy) | 2022-01-04 | 2028-01-03 | Common Stock | 19895 | $56.78 | D |  |
| Non-Qualified Stock Option (right to buy) | 2021-01-02 | 2027-01-01 | Common Stock | 28951 | $60.89 | D |  |
| Restricted Stock Unit<sup>(1)</sup> | 2026-01-15<sup>(2)</sup> | <sup>(2)</sup> | Common Stock | 31949 | $0.0 | D |  |

---

### Footnotes:

(1) Each restricted stock unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

(2) Grants to reporting person of restricted stock units under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan on January 15, 2022, January 15, 2023, January 15, 2024, and January 15, 2025. The restricted stock units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

**Signature:** By: Patrick R. O'Neil, attorney-in-fact For: Holly Kordasiewicz  
**Date:** 2026-01-05

### Remarks:

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

**Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.**