# EDGAR Filing Document

**Accession Number:** 0000942257
**File Stem:** 0000950123-23-000575
**Filing Date:** 2023-2
**Character Count:** 10046
**Document Hash:** 6b9cd21c4b99c25582c8b47f44c56286
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000950123-23-000575.hdr.sgml**: 20230201

**ACCESSION NUMBER**: 0000950123-23-000575

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230201

**DATE AS OF CHANGE**: 20230201

**EFFECTIVENESS DATE**: 20230201

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** INTERNATIONAL BIOTECHNOLOGY TRUST PLC
- **CENTRAL INDEX KEY:** 0000942257
- **IRS NUMBER:** 000000000

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-18673
- **FILM NUMBER:** 23574676

**BUSINESS ADDRESS:**
- **STREET 1:** 6TH FLOOR, 65 GRESHAM STREET
- **CITY:** LONDON
- **STATE:** X0
- **ZIP:** EC2V 7NQ
- **BUSINESS PHONE:** 44 (0) 20 7421 7070

**MAIL ADDRESS:**
- **STREET 1:** 6TH FLOOR, 65 GRESHAM STREET
- **CITY:** LONDON
- **STATE:** X0
- **ZIP:** EC2V 7NQ

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2022

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** INTERNATIONAL BIOTECHNOLOGY TRUST PLC<br>**Address:** 6th Floor 65 Gresham Street<br>London, X0 EC2V 7NQ

**Form 13F File Number:** 028-18673

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** James Costine<br>**Title:** Authorised Signatory<br>**Phone:** 0044 2074217081

**Signature, Place, and Date of Signing:**

James Costine  London, X0  01-31-2023<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 63

**Form 13F Information Table Value Total:** $323783349

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| ACADIA PHARMACEUTICALS IN | COM | 004225108 |  | 1590000 | 100000 | SH |  | SOLE |  | 100000 | 0 | 0 |
| ADICET BIO INC COM | COM | 007002108 |  | 1379995 | 154708 | SH |  | SOLE |  | 154708 | 0 | 0 |
| ALBIREO PHARMA INC COM | COM | 01345P106 |  | 820420 | 38000 | SH |  | SOLE |  | 38000 | 0 | 0 |
| ALKERMES PLC SHS | SHS | G01767105 |  | 15483230 | 593000 | SH |  | SOLE |  | 593000 | 0 | 0 |
| ALLOGENE THERAPEUTICS INC | COM | 019770106 |  | 314000 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| ALNYLAM PHARMACEUTICALS I | COM | 02043Q107 |  | 9018160 | 38000 | SH |  | SOLE |  | 38000 | 0 | 0 |
| AMGEN INC COM | COM | 031162100 |  | 4265225 | 16246 | SH |  | SOLE |  | 16246 | 0 | 0 |
| APELLIS PHARMACEUTICALS I | COM | 03753U106 |  | 1638256 | 31700 | SH |  | SOLE |  | 31700 | 0 | 0 |
| ARVINAS INC COM | COM | 04335A105 |  | 580550 | 17000 | SH |  | SOLE |  | 17000 | 0 | 0 |
| ASCENDIS PHARMA A/S SPONS | Sponsored ADR | 04351P101 |  | 3588270 | 29400 | SH |  | SOLE |  | 29400 | 0 | 0 |
| ASTRAZENECA PLC SPONSORED | SPONSORED ADR | 046353108 |  | 4406350 | 65000 | SH |  | SOLE |  | 65000 | 0 | 0 |
| AURINIA PHARMACEUTICALS I | COM | 05156V102 |  | 2477650 | 573530 | SH |  | SOLE |  | 573530 | 0 | 0 |
| BEAM THERAPEUTICS INC COM | COM | 07373V105 |  | 919085 | 23500 | SH |  | SOLE |  | 23500 | 0 | 0 |
| BEIGENE LTD SPONSORED ADR | Sponsored ADR | 07725L102 |  | 3452116 | 15700 | SH |  | SOLE |  | 15700 | 0 | 0 |
| BIOCRYST PHARMACEUTICALS | COM | 09058V103 |  | 653790 | 57000 | SH |  | SOLE |  | 57000 | 0 | 0 |
| BIOGEN INC COMMON STOCK | COM | 09062X103 |  | 5923520 | 21400 | SH |  | SOLE |  | 21400 | 0 | 0 |
| BIOMARIN PHARMACEUTICAL I | COM | 09061G101 |  | 4514467 | 43656 | SH |  | SOLE |  | 43656 | 0 | 0 |
| BLACK DIAMOND THERAPEUTIC | COM | 0920E3105 |  | 79200 | 44000 | SH |  | SOLE |  | 44000 | 0 | 0 |
| CARIBOU BIOSCIENCES INC C | COM | 142038108 |  | 1619562 | 257892 | SH |  | SOLE |  | 257892 | 0 | 0 |
| CHINOOK THERAPEUTICS INC | COM | 16961L106 |  | 8914788 | 340389 | SH |  | SOLE |  | 340389 | 0 | 0 |
| CONCERT PHARMACEUTICALS I | COM | 206022105 |  | 1172672 | 200800 | SH |  | SOLE |  | 200800 | 0 | 0 |
| CRISPR THERAPEUTICS AG CO | NAMEN AKT | H17182108 |  | 1390230 | 34200 | SH |  | SOLE |  | 34200 | 0 | 0 |
| DENALI THERAPEUTICS INC C | COM | 24823R105 |  | 1056020 | 38000 | SH |  | SOLE |  | 38000 | 0 | 0 |
| DYNE THERAPEUTICS INC COM | COM | 26818M108 |  | 7417157 | 641068 | SH |  | SOLE |  | 641068 | 0 | 0 |
| EXELIXIS INC COM | COM | 30161Q104 |  | 8709720 | 543000 | SH |  | SOLE |  | 543000 | 0 | 0 |
| FATE THERAPEUTICS INC COM | COM | 31189P102 |  | 463680 | 46000 | SH |  | SOLE |  | 46000 | 0 | 0 |
| FULCRUM THERAPEUTICS INC | COM | 359616109 |  | 1408497 | 193741 | SH |  | SOLE |  | 193741 | 0 | 0 |
| GILEAD SCIENCES INC COMMO | COM | 375558103 |  | 4942435 | 57584 | SH |  | SOLE |  | 57584 | 0 | 0 |
| GUARDANT HEALTH INC COM | COM | 40131M109 |  | 2024165 | 74500 | SH |  | SOLE |  | 74500 | 0 | 0 |
| Harmony Biosciences Holdi | COM | 413197104 |  | 14560725 | 264500 | SH |  | SOLE |  | 264500 | 0 | 0 |
| HORIZON THERAPEUTICS PLC | SHS | G4617B105 |  | 35828179 | 314973 | SH |  | SOLE |  | 314973 | 0 | 0 |
| HUTCHMED CHINA LIMITED SP | SPONSORED ADS | 44842L103 |  | 1003000 | 68000 | SH |  | SOLE |  | 68000 | 0 | 0 |
| IDEAYA BIOSCIENCES INC CO | COM | 45166A102 |  | 1980530 | 109000 | SH |  | SOLE |  | 109000 | 0 | 0 |
| ILLUMINA INC COM | COM | 452327109 |  | 9396720 | 46500 | SH |  | SOLE |  | 46500 | 0 | 0 |
| I-MAB SPONSORED ADS | SPONSORED ADS | 44975P103 |  | 1291676 | 310499 | SH |  | SOLE |  | 310499 | 0 | 0 |
| INCYTE CORP INC COM | COM | 45337C102 |  | 18390990 | 229000 | SH |  | SOLE |  | 229000 | 0 | 0 |
| INSMED INC COM PAR $.01 | COM | 457669307 |  | 800396 | 40100 | SH |  | SOLE |  | 40100 | 0 | 0 |
| INTELLIA THERAPEUTICS INC | COM | 45826J105 |  | 836640 | 24000 | SH |  | SOLE |  | 24000 | 0 | 0 |
| INTRA-CELLULAR THERAPIES | COM | 46116X101 |  | 11733964 | 221856 | SH |  | SOLE |  | 221856 | 0 | 0 |
| IOVANCE BIOTHERAPEUTICS I | COM | 462260100 |  | 357280 | 56000 | SH |  | SOLE |  | 56000 | 0 | 0 |
| IRONWOOD PHARMACEUTICALS | COM | 46333X108 |  | 743400 | 60000 | SH |  | SOLE |  | 60000 | 0 | 0 |
| JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 |  | 2739444 | 17200 | SH |  | SOLE |  | 17200 | 0 | 0 |
| KRYSTAL BIOTECH INC COM | COM | 501147102 |  | 3558150 | 45000 | SH |  | SOLE |  | 45000 | 0 | 0 |
| Legend Biotech Corp | SPONSORED ADS | 52490G102 |  | 1894300 | 38000 | SH |  | SOLE |  | 38000 | 0 | 0 |
| MIRATI THERAPEUTICS INC C | COM | 60468T105 |  | 11055640 | 244000 | SH |  | SOLE |  | 244000 | 0 | 0 |
| MIRUM PHARMACEUTICALS INC | COM | 604749101 |  | 1312875 | 67500 | SH |  | SOLE |  | 67500 | 0 | 0 |
| NOVAVAX INC | COM | 670002401 |  | 1360775 | 132500 | SH |  | SOLE |  | 132500 | 0 | 0 |
| Novocure Ltd | ORD SHS | G6674U108 |  | 2344000 | 32000 | SH |  | SOLE |  | 32000 | 0 | 0 |
| PTC THERAPEUTICS INC COM | COM | 69366J200 |  | 5493600 | 144000 | SH |  | SOLE |  | 144000 | 0 | 0 |
| REGENERON PHARMACEUTICALS | COM | 75886F107 |  | 8080128 | 11200 | SH |  | SOLE |  | 11200 | 0 | 0 |
| RELMADA THERAPEUTICS INC | COM | 75955J402 |  | 34900 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| REVANCE THERAPEUTICS INC | COM | 761330109 |  | 2214000 | 120000 | SH |  | SOLE |  | 120000 | 0 | 0 |
| ROCKET PHARMACEUTICALS IN | COM | 77313F106 |  | 1231020 | 63000 | SH |  | SOLE |  | 63000 | 0 | 0 |
| SANOFI | SPONSORED ADR | 80105N105 |  | 6942530 | 143500 | SH |  | SOLE |  | 143500 | 0 | 0 |
| SEAGEN INC COM | COM | 81181C104 |  | 21356700 | 166200 | SH |  | SOLE |  | 166200 | 0 | 0 |
| SUPERNUS PHARMACEUTICALS | COM | 868459108 |  | 13671775 | 383500 | SH |  | SOLE |  | 383500 | 0 | 0 |
| TRAVERE THERAPEUTICS INC | COM | 89422G107 |  | 7963189 | 379019 | SH |  | SOLE |  | 379019 | 0 | 0 |
| ULTRAGENYX PHARMACEUTICAL | COM | 90400D108 |  | 8060348 | 174052 | SH |  | SOLE |  | 174052 | 0 | 0 |
| UNIQURE N.V. COM EUR0.05 | SHS | N90064101 |  | 14297160 | 631500 | SH |  | SOLE |  | 631500 | 0 | 0 |
| UNITED THERAPEUTICS CORP | COM | 91307C102 |  | 4171200 | 15000 | SH |  | SOLE |  | 15000 | 0 | 0 |
| VERA THERAPEUTICS | CL A | 92337R101 |  | 5428260 | 281257 | SH |  | SOLE |  | 281257 | 0 | 0 |
| XENON PHARMACEUTICALS INC | COM | 98420N105 |  | 1003425 | 25500 | SH |  | SOLE |  | 25500 | 0 | 0 |
| ZAI LAB LTD ADR | ADR | 98887Q104 |  | 2423221 | 78958 | SH |  | SOLE |  | 78958 | 0 | 0 |

---