# EDGAR Filing Document

**Accession Number:** 0002006986
**File Stem:** 0001104659-26-039213
**Filing Date:** 2026-4
**Character Count:** 10008
**Document Hash:** 6eeb6eca188a1c8a3a6f48e68e9b7d9a
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-26-039213.hdr.sgml**: 20260402

**ACCESSION NUMBER**: 0001104659-26-039213

**CONFORMED SUBMISSION TYPE**: S-8 POS

**PUBLIC DOCUMENT COUNT**: 2

**FILED AS OF DATE**: 20260402

**DATE AS OF CHANGE**: 20260402

**EFFECTIVENESS DATE**: 20260402

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Adagio Medical Holdings, Inc.
- **CENTRAL INDEX KEY:** 0002006986
- **STANDARD INDUSTRIAL CLASSIFICATION:** SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
- **ORGANIZATION NAME:** 08 Industrial Applications and Services
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8 POS
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-294719
- **FILM NUMBER:** 26834528

**BUSINESS ADDRESS:**
- **STREET 1:** 26051 MERIT CIRCLE
- **STREET 2:** SUITE 102
- **CITY:** LAGUNA HILLS
- **STATE:** CA
- **ZIP:** 92653
- **BUSINESS PHONE:** (949) 348-1188

**MAIL ADDRESS:**
- **STREET 1:** 26051 MERIT CIRCLE
- **STREET 2:** SUITE 102
- **CITY:** LAGUNA HILLS
- **STATE:** CA
- **ZIP:** 92653

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Aja Holdco, Inc.
- **DATE OF NAME CHANGE:** 20240104

**As filed with the Securities and Exchange Commission on April 2, 2026**

**Registration No. 333-294719**

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**POST-EFFECTIVE AMENDMENT NO. 1 TO**

**FORM S-8**

**REGISTRATION STATEMENT**

***UNDER***

***THE SECURITIES ACT OF 1933***

**Adagio Medical Holdings, Inc.**

**(Exact name of Registrant as specified in its charter)**

---

| | |
|:---|:---|
| **Delaware** | **99-1151466** |
| **(State or other jurisdiction of**<br> **incorporation or organization)** | **(I.R.S. Employer**<br> **Identification Number)** |
| **26051 Merit Circle, Suite 102**<br> **Laguna Hills, California** | **92653** |
| **(Address of Principal Executive Offices)** | **(Zip Code)** |

---

**Adagio Medical Holdings, Inc. 2024 Equity Incentive Plan**

**(Full Title of the Plans)**

**Todd Usen**

**Chief Executive Officer**

**Adagio Medical Holdings, Inc.**

**26051 Merit Circle, Suite 102**

**Laguna Hills, California 92653**

**(949) 348-1188**

**(Name, address, including zip code, and telephone number, including area code, of agent for service)**

*Copies to:*

**Eric Blanchard**

**Paul Alexander**

**Cooley LLP**

**500 Boylston Street, 14th Floor**

**Boston, MA 02116**

**Tel: (617) 937-2300**

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.

Large accelerated filer ◻ Accelerated filer ◻ <br> Non-accelerated filer ⌧ Smaller reporting company ⌧ <br> Emerging growth company ⌧

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ◻

**EXPLANATORY NOTE**

This Post-Effective Amendment No. 1 to the Registration Statement on Form S-8 (File No. 333-294719), originally filed by Adagio Medical Holdings, Inc. (the "Registrant") with the Securities and Exchange Commission on March 30, 2026, is being filed solely to correct Exhibit 23.1, the Consent of Independent Registered Public Accounting Firm. The original filing mistakenly included a version of the consent with an incorrect date for the report of WithumSmith + Brown, PC with respect to the Registrant's consolidated financial statements included in the Registrant's Annual Report on Form 10-K for the year ended December 31, 2025. No other changes have been made to the Registration Statement.

**Item 8. Exhibits.**

Reference is made under this Item 8 to the exhibit index included in this Registration Statement.

**Exhibit Index**

---

| | |
|:---|:---|
| **Exhibit<br> Number** | **Exhibit Description** |
| [4.1](https://www.sec.gov/Archives/edgar/data/2006986/000114036124035942/ef20033584_ex3-1.htm) | [Amended and Restated Certificate of Incorporation of the Registrant (incorporated herein by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K filed with the Commission on August 6, 2024).](https://www.sec.gov/Archives/edgar/data/2006986/000114036124035942/ef20033584_ex3-1.htm) |
| [4.2](https://www.sec.gov/Archives/edgar/data/2006986/000114036124035942/ef20033584_ex3-2.htm) | [Amended and Restated By-Laws of the Registrant (incorporated herein by reference to Exhibit 3.2 to the Registrant's Current Report on Form 8-K filed with the Commission on August 6, 2024).](https://www.sec.gov/Archives/edgar/data/2006986/000114036124035942/ef20033584_ex3-2.htm) |
| [4.3](https://www.sec.gov/Archives/edgar/data/2006986/000114036124035942/ef20033584_ex4-4.htm) | [Specimen Common Stock Certificate of Registrant (incorporated herein by reference to Exhibit 4.4 to the Registrant's Current Report on Form 8-K filed with the Commission on August 6, 2024).](https://www.sec.gov/Archives/edgar/data/2006986/000114036124035942/ef20033584_ex4-4.htm) |
| [4.4](https://www.sec.gov/Archives/edgar/data/2006986/000114036124035942/ef20033584_ex10-5.htm) | [Registrant's 2024 Equity Incentive Plan (incorporated herein by reference to Exhibit 10.5 to the Registrant's Current Report on Form 8-K filed with the Commission on August 6, 2024).](https://www.sec.gov/Archives/edgar/data/2006986/000114036124035942/ef20033584_ex10-5.htm) |
| [5.1](http://www.sec.gov/Archives/edgar/data/2006986/000110465926036287/tm269982d1_ex5-1.htm) | [Opinion of Cooley LLP (incorporated herein by reference to Exhibit 5.1 to the Registrant's Registration Statement on Form S-8 filed with the Commission on March 30, 2026).](http://www.sec.gov/Archives/edgar/data/2006986/000110465926036287/tm269982d1_ex5-1.htm) |
| [23.1\*](tm2611014d1_ex23-1.htm) | [Consent of WithumSmith+Brown, PC, independent registered public accounting firm for Adagio Medical Holdings, Inc.](tm2611014d1_ex23-1.htm) |
| [23.2](http://www.sec.gov/Archives/edgar/data/2006986/000110465926036287/tm269982d1_ex5-1.htm) | [Consent of Cooley LLP (included as part of Exhibit 5.1) (incorporated herein by reference to Exhibit 23.2 to the Registrant's Registration Statement on Form S-8 filed with the Commission on March 30, 2026).](http://www.sec.gov/Archives/edgar/data/2006986/000110465926036287/tm269982d1_ex5-1.htm) |
| [24.1](http://www.sec.gov/Archives/edgar/data/2006986/000110465926036287/tm269982d1_s8.htm#a_001) | [Power of Attorney (included on the signature page hereto) (incorporated herein by reference to Exhibit 24.1 to the Registrant's Registration Statement on Form S-8 filed with the Commission on March 30, 2026).](http://www.sec.gov/Archives/edgar/data/2006986/000110465926036287/tm269982d1_s8.htm#a_001) |
| [107](http://www.sec.gov/Archives/edgar/data/2006986/000110465926036287/tm269982d1_ex-filingfees.htm) | [Filing Fee Table (incorporated herein by reference to Exhibit 107 to the Registrant's Registration Statement on Form S-8 filed with the Commission on March 30, 2026).](http://www.sec.gov/Archives/edgar/data/2006986/000110465926036287/tm269982d1_ex-filingfees.htm) |

---

\* Filed herewith.

S**IGNATURES**

Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Laguna Hills, State of California, on this 2nd day of April, 2026.

---

| | |
|:---|:---|
|  | **Adagio Medical Holdings, Inc.** |
| By: | /s/ Todd Usen |
|  | Todd Usen |
|  | *Chief Executive Officer* |

---

Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the date indicated.

---

| | | |
|:---|:---|:---|
| **Signature** | **Title** | **Date** |
| <br> /s/ Todd Usen | Chief Executive Officer and Director<br> *(Principal Executive Officer)* | April 2, 2026 |
| Todd Usen |  |  |
| /s/ Deborah Kaster | Chief Financial Officer | April 2, 2026 |
| Deborah Kaster | *(Principal Financial and Accounting Officer)* |  |
| \* | Director | April 2, 2026 |
| James L. Cox |  |  |
| \* | Director | April 2, 2026 |
| Orly Mishan |  |  |
| \* | Director | April 2, 2026 |
| Keyvan Mirsaeedi-Farahani |  |  |
| \* | Director | April 2, 2026 |
| Sean Salmon |  |  |
| \* | Director | April 2, 2026 |
| Timothy Moran |  |  |
| \* | Director | April 2, 2026 |
| Sandra Gardiner |  |  |
| /s/ Todd Usen |  |  |
| Todd Usen |  |  |
| Attorney-in-fact |  |  |

---

## Exhibit 23.1

**Exhibit 23.1**

**CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM**

We hereby consent to the incorporation by reference in the Registration Statements on Form S-8 (No. 333-294719) of Adagio Medical Holdings, Inc. of our report dated March 26, 2026, which includes an explanatory paragraph regarding Adagio Medical Holdings, Inc.'s ability to continue as a going concern, relating to the consolidated balance sheets of Adagio Medical Holdings, Inc. as of December 31, 2025 and 2024, and the related consolidated statements of operations and comprehensive loss, stockholders' equity (deficit), and cash flows for the year ended December 31, 2025 and the periods July 31 to December 31, 2024 (Successor) and January 1 to July 30, 2024 (Predecessor), appearing in the Company's Annual Report on Form 10-K for the years ended December 31, 2025 and 2024.

We also consent to the reference to us under the caption "Experts" in the Registration Statements.

/s/ WithumSmith+Brown, PC

Whippany, New Jersey

April 2, 2026