# EDGAR Filing Document

**Accession Number:** 0001284386
**File Stem:** 0001178913-23-000834
**Filing Date:** 2023-3
**Character Count:** 33521
**Document Hash:** 9e8e96fff75c4163b539292dda811a89
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001178913-23-000834.hdr.sgml**: 20230302

**ACCESSION NUMBER**: 0001178913-23-000834

**CONFORMED SUBMISSION TYPE**: SC 13G/A

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20230302

**DATE AS OF CHANGE**: 20230302

**GROUP MEMBERS**: BATSHEVA ELRAN

**GROUP MEMBERS**: MEDICA III INVESTMENTS (INTERNATIONAL) L.P.

**GROUP MEMBERS**: MEDICA III INVESTMENTS (ISRAEL) (B) L.P.

**GROUP MEMBERS**: MEDICA III INVESTMENTS (ISRAEL) L.P.

**GROUP MEMBERS**: MEDICA III INVESTMENTS (P.F.) L.P.

**GROUP MEMBERS**: MEDICA III INVESTMENTS (S.F.) L.P.

**GROUP MEMBERS**: MEDICA III MANAGEMENT CO.

**GROUP MEMBERS**: MEDICA III MANAGEMENT L.P.

**GROUP MEMBERS**: POALIM MEDICA III INVESTMENTS L.P.

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** PAINREFORM LTD.
- **CENTRAL INDEX KEY:** 0001801834
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** L3
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G/A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-91649
- **FILM NUMBER:** 23699493

**BUSINESS ADDRESS:**
- **STREET 1:** 65 YIGAL ALON ST.
- **CITY:** TEL AVIV
- **STATE:** L3
- **ZIP:** 6744316
- **BUSINESS PHONE:** 972-3-7177051

**MAIL ADDRESS:**
- **STREET 1:** 65 YIGAL ALON ST.
- **CITY:** TEL AVIV
- **STATE:** L3
- **ZIP:** 6744316
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** GELLER EHUD
- **CENTRAL INDEX KEY:** 0001284386

**FILING VALUES:**
- **FORM TYPE:** SC 13G/A

**MAIL ADDRESS:**
- **STREET 1:** 100 PHILIPS PARKWAY
- **CITY:** MONTVALE
- **STATE:** NJ
- **ZIP:** 07645

------

### SECURITIES AND EXCHANGE COMMISSION

#### WASHINGTON, D.C. 20549

------

### SCHEDULE 13G

#### UNDER THE SECURITIES EXCHANGE ACT OF 1934

#### (Amendment No. 2)\*

#### PainReform Ltd.
(Name of Issuer)

#### Ordinary Shares, par value NIS 0.03 per share
(Title of Class of Securities)

#### M77798102
(CUSIP Number)

#### December 31, 2022
(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

<br> ☐ Rule 13d-1(b)

<br> ☐ Rule 13d-1(c)

<br> ☒ Rule 13d-1(d)

\* The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934, as amended (the "<u>Act</u>") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

&nbsp;&nbsp;&nbsp;&nbsp;<br>

------

---

| | | |
|:---|:---|:---|
| **CUSIP No. <u>M77798102</u>** | **13G** | **Page 2 of 19 Pages** |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**1.** Names of Reporting Persons. Medica III Management Co.

**2.** Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☒

**3.** SEC Use Only

**4.** Citizenship or Place of Organization Cayman Islands

---

| | | |
|:---|:---|:---|
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **5.** | Sole Voting Power<br>3,292,250 (1) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **6.** | Shared Voting Power<br>0 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **7.** | Sole Dispositive Power<br>3,292,250 (1) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **8.** | Shared Dispositive Power<br>0 |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**9.** Aggregate Amount Beneficially Owned by Each Reporting Person 3,292,250 (1)

**10.** Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ☐

**11.** Percent of Class Represented by Amount in Row (9) 31.0% (1)

**12.** Type of Reporting Person (See Instructions) PN

(1) This amount of shares and percentage relates to all the Reporting Persons and is based on 10,634,166 Ordinary Shares of the Issuer's issued and outstanding as of September 30, 2022, which number
 appeared in the Issuer's unaudited condensed financial statements as of September 30, 2022, filed as Exhibit 99.1 to its Current Report on Form 6-K, filed with the Securities and Exchange Commission ("SEC") on November 14, 2022.

------

---

| | | |
|:---|:---|:---|
| **CUSIP No. <u>M77798102</u>** | **13G** | **Page 3 of 19 Pages** |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**1.** Names of Reporting Persons. Medica III Management L.P.

**2.** Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☒

**3.** SEC Use Only

**4.** Citizenship or Place of Organization Cayman Islands

---

| | | |
|:---|:---|:---|
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **5.** | Sole Voting Power<br>3,292,250 (1) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **6.** | Shared Voting Power<br>0 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **7.** | Sole Dispositive Power<br>3,292,250 (1) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **8.** | Shared Dispositive Power<br>0 |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**9.** Aggregate Amount Beneficially Owned by Each Reporting Person 3,292,250 (1)

**10.** Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ☐

**11.** Percent of Class Represented by Amount in Row (9) 31.0% (1)

**12.** Type of Reporting Person (See Instructions) CO

(1) This amount of shares and percentage relates to all the Reporting Persons and is based on 10,634,166 Ordinary Shares of the Issuer's issued and outstanding as of
 September 30, 2022, which number appeared in the Issuer's unaudited condensed financial statements as of September 30, 2022, filed as Exhibit 99.1 to its Current Report on Form 6-K, filed with the SEC on November 14, 2022.

------

---

| | | |
|:---|:---|:---|
| **CUSIP No. <u>M77798102</u>** | **13G** | **Page 4 of 19 Pages** |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**1.** Names of Reporting Persons. Medica III Investments (International) L.P.

**2.** Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☒

**3.** SEC Use Only

**4.** Citizenship or Place of Organization Cayman Islands

---

| | | |
|:---|:---|:---|
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **5.** | Sole Voting Power<br>3,292,250 (1) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **6.** | Shared Voting Power<br>0 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **7.** | Sole Dispositive Power<br>3,292,250 (1) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **8.** | Shared Dispositive Power<br>0 |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**9.** Aggregate Amount Beneficially Owned by Each Reporting Person 3,292,250 (1)

**10.** Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ☐

**11.** Percent of Class Represented by Amount in Row (9) 31.0% (1)

**12.** Type of Reporting Person (See Instructions) PN

(1) This amount of shares and percentage relates to all the Reporting Persons and is based on 10,634,166 Ordinary Shares of the Issuer's issued and outstanding as of
 September 30, 2022, which number appeared in the Issuer's unaudited condensed financial statements as of September 30, 2022, filed as Exhibit 99.1 to its Current Report on Form 6-K, filed with the SEC on November 14, 2022.

------

---

| | | |
|:---|:---|:---|
| **CUSIP No. <u>M77798102</u>** | **13G** | **Page 5 of 19 Pages** |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**1.** Names of Reporting Persons. Medica III Investments (Israel) L.P.

**2.** Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☒

**3.** SEC Use Only

**4.** Citizenship or Place of Organization Israel

---

| | | |
|:---|:---|:---|
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **5.** | Sole Voting Power<br>3,292,250 (1) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **6.** | Shared Voting Power<br>0 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **7.** | Sole Dispositive Power<br>3,292,250 (1) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **8.** | Shared Dispositive Power<br>0 |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**9.** Aggregate Amount Beneficially Owned by Each Reporting Person 3,292,250 (1)

**10.** Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ☐

**11.** Percent of Class Represented by Amount in Row (9) 31.0% (1)

**12.** Type of Reporting Person (See Instructions) PN

(1) This amount of shares and percentage relates to all the Reporting Persons and is based on 10,634,166 Ordinary Shares of the
 Issuer's issued and outstanding as of September 30, 2022, which number appeared in the Issuer's unaudited condensed financial statements as of September 30, 2022, filed as Exhibit 99.1 to its Current Report on Form 6-K, filed with the
 SEC on November 14, 2022.

------

---

| | | |
|:---|:---|:---|
| **CUSIP No. <u>M77798102</u>** | **13G** | **Page 6 of 19 Pages** |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**1.** Names of Reporting Persons. Medica III Investments (S.F.) L.P.

**2.** Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☒

**3.** SEC Use Only

**4.** Citizenship or Place of Organization Cayman Islands

---

| | | |
|:---|:---|:---|
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **5.** | Sole Voting Power<br>3,292,250 (1) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **6.** | Shared Voting Power<br>0 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **7.** | Sole Dispositive Power<br>3,292,250 (1) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **8.** | Shared Dispositive Power<br>0 |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**9.** Aggregate Amount Beneficially Owned by Each Reporting Person 3,292,250 (1)

**10.** Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ☐

**11.** Percent of Class Represented by Amount in Row (9) 31.0% (1)

**12.** Type of Reporting Person (See Instructions) PN

(1) This amount of shares and percentage relates to all the Reporting Persons and is based on 10,634,166 Ordinary Shares of the
 Issuer's issued and outstanding as of September 30, 2022, which number appeared in the Issuer's unaudited condensed financial statements as of September 30, 2022, filed as Exhibit 99.1 to its Current Report on Form 6-K, filed with the
 SEC on November 14, 2022.

------

---

| | | |
|:---|:---|:---|
| **CUSIP No. <u>M77798102</u>** | **13G** | **Page 7 of 19 Pages** |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**1.** Names of Reporting Persons. Medica III Investments (P.F.) L.P.

**2.** Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☒

**3.** SEC Use Only

**4.** Citizenship or Place of Organization Israel

---

| | | |
|:---|:---|:---|
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **5.** | Sole Voting Power<br>3,292,250 (1) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **6.** | Shared Voting Power<br>0 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **7.** | Sole Dispositive Power<br>3,292,250 (1) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **8.** | Shared Dispositive Power<br>0 |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**9.** Aggregate Amount Beneficially Owned by Each Reporting Person 3,292,250 (1)

**10.** Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ☐

**11.** Percent of Class Represented by Amount in Row (9) 31.0% (1)

**12.** Type of Reporting Person (See Instructions) PN

(1) This amount of shares and percentage relates to all the Reporting Persons and is based on 10,634,166 Ordinary Shares of the Issuer's issued and outstanding as of
 September 30, 2022, which number appeared in the Issuer's unaudited condensed financial statements as of September 30, 2022, filed as Exhibit 99.1 to its Current Report on Form 6-K, filed with the SEC on November 14, 2022.

------

---

| | | |
|:---|:---|:---|
| **CUSIP No. <u>M77798102</u>** | **13G** | **Page 8 of 19 Pages** |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**1.** Names of Reporting Persons. Medica III Investments (Israel) (B) L.P.

**2.** Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☒

**3.** SEC Use Only

**4.** Citizenship or Place of Organization Israel

---

| | | |
|:---|:---|:---|
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **5.** | Sole Voting Power<br>3,292,250 (1) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **6.** | Shared Voting Power<br>0 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **7.** | Sole Dispositive Power<br>3,292,250 (1) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **8.** | Shared Dispositive Power<br>0 |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**9.** Aggregate Amount Beneficially Owned by Each Reporting Person 3,292,250 (1)

**10.** Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ☐

**11.** Percent of Class Represented by Amount in Row (9) 31.0% (1)

**12.** Type of Reporting Person (See Instructions) PN

(1) This amount of shares and percentage relates to all the Reporting Persons and is based on 10,634,166 Ordinary Shares of the
 Issuer's issued and outstanding as of September 30, 2022, which number appeared in the Issuer's unaudited condensed financial statements as of September 30, 2022, filed as Exhibit 99.1 to its Current Report on Form 6-K, filed with the
 SEC on November 14, 2022.

------

---

| | | |
|:---|:---|:---|
| **CUSIP No. <u>M77798102</u>** | **13G** | **Page 9 of 19 Pages** |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**1.** Names of Reporting Persons. Poalim Medica III Investments L.P.

**2.** Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☒

**3.** SEC Use Only

**4.** Citizenship or Place of Organization Israel

---

| | | |
|:---|:---|:---|
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **5.** | Sole Voting Power<br>3,292,250 (1) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **6.** | Shared Voting Power<br>0 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **7.** | Sole Dispositive Power<br>3,292,250 (1) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **8.** | Shared Dispositive Power<br>0 |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**9.** Aggregate Amount Beneficially Owned by Each Reporting Person 3,292,250 (1)

**10.** Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ☐

**11.** Percent of Class Represented by Amount in Row (9) 31.0% (1)

**12.** Type of Reporting Person (See Instructions) PN

(1) This amount of shares and percentage relates to all the Reporting Persons and is based on 10,634,166 Ordinary Shares of the
 Issuer's issued and outstanding as of September 30, 2022, which number appeared in the Issuer's unaudited condensed financial statements as of September 30, 2022, filed as Exhibit 99.1 to its Current Report on Form 6-K, filed with the
 SEC on November 14, 2022.

------

---

| | | |
|:---|:---|:---|
| **CUSIP No. <u>M77798102</u>** | **13G** | **Page 10 of 19 Pages** |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**1.** Names of Reporting Persons. Ehud Geller

**2.** Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☒

**3.** SEC Use Only

**4.** Citizenship or Place of Organization Israel

---

| | | |
|:---|:---|:---|
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **5.** | Sole Voting Power<br>0 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **6.** | Shared Voting Power<br>3,292,250 (1) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **7.** | Sole Dispositive Power<br>0 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **8.** | Shared Dispositive Power<br>3,292,250 (1) |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**9.** Aggregate Amount Beneficially Owned by Each Reporting Person 3,292,250 (1)

**10.** Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ☐

**11.** Percent of Class Represented by Amount in Row (9) 31.0% (1)

**12.** Type of Reporting Person (See Instructions) IN

(1) This amount of shares and percentage relates to all the Reporting Persons and is based on 10,634,166 Ordinary Shares of the
 Issuer's issued and outstanding as of September 30, 2022, which number appeared in the Issuer's unaudited condensed financial statements as of September 30, 2022, filed as Exhibit 99.1 to its Current Report on Form 6-K, filed with the
 SEC on November 14, 2022.

------

---

| | | |
|:---|:---|:---|
| **CUSIP No. <u>M77798102</u>** | **13G** | **Page 11 of 19 Pages** |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**1.** Names of Reporting Persons. Batsheva Elran

**2.** Check the Appropriate Box if a Member of a Group (See Instructions) (a) ☐ (b) ☒

**3.** SEC Use Only

**4.** Citizenship or Place of Organization Israel

---

| | | |
|:---|:---|:---|
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **5.** | Sole Voting Power<br>0 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **6.** | Shared Voting Power<br>3,292,250 (1) |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **7.** | Sole Dispositive Power<br>0 |
| Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person with | **8.** | Shared Dispositive Power<br>3,292,250 (1) |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**9.** Aggregate Amount Beneficially Owned by Each Reporting Person 3,292,250 (1)

**10.** Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ☐

**11.** Percent of Class Represented by Amount in Row (9) 31.0% (1)

**12.** Type of Reporting Person (See Instructions) IN

(1) This amount of shares and percentage relates to all the Reporting Persons and is based on 10,634,166 Ordinary Shares of the
 Issuer's issued and outstanding as of September 30, 2022, which number appeared in the Issuer's unaudited condensed financial statements as of September 30, 2022, filed as Exhibit 99.1 to its Current Report on Form 6-K, filed with the
 SEC on November 14, 2022.

------

---

| | |
|:---|:---|
| **Item 1(a).** | **Name of Issuer:** |

---

The name of the issuer is PainReform Ltd.

**Item 1(b). Address of Issuer's Principal Executive Offices:**

The Issuer's principal executive offices are located at 60C Medinat Hayehudim, Herzliya, 4676652, Israel.

---

| | |
|:---|:---|
| **Item 2(a).** | **Name of Person Filing:** |

---

The following entity and individuals, listed in (i)-(viii) below, who are filing this Statement of Beneficial Ownership on Schedule 13G (this "**Statement**"), are referred to herein collectively as the "**Reporting Persons**":

**General Partners**:

Medica III Management Co., a Cayman Islands corporation

Medica III Management L.P., a Cayman Islands limited partnership

**Investment Funds:**

Medica III Investments (International) L.P. a Cayman Islands limited Partnership

Medica III Investments (Israel) L.P. an Israeli limited partnership

Medica III Investments (S.F.) L.P. a Cayman Islands limited partnership

Medica III Investments (P.F.) L.P. an Israeli limited partnership

Medica III Investments (Israel) (B) L.P. an Israeli limited partnership

Poalim Medica III Investments L.P. an Israeli limited partnership

**Officers/Directors:**<br>

**** 

<br> Ehud Geller, an Israeli citizen and an officer and director of Medica III Investment group.

Batsheva Elran, an Israeli citizen and an officer and director of Medica III Investment group.

---

| | |
|:---|:---|
| **Item 2(b).** | **Address of Principal Business Office or, if None, Residence:** |

---

The principal business office of each Reporting Person is as follows:

c/o Medica III Investment Group

60C Medinat Hayehudim

Herzliya, 44676652, Israel

---

| | |
|:---|:---|
| **Item 2(c).** | **Citizenship:** |

---

Each of the entities or persons identified in Item 2(a) above is a corporation, limited partnership or individual organized under the laws of the jurisdiction, or is a citizen of the jurisdiction, as applicable, set forth opposite such entity's or person's name.

------

---

| | |
|:---|:---|
| **Item 2(d).** | **Title of Class of Securities:** |

---

Ordinary shares, par value NIS 0.03 per share.

---

| | |
|:---|:---|
| **Item 2(e).** | **CUSIP Number:** |

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The CUSIP number of the Ordinary Shares is M77798102.

**Item 3.** **If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b), or (c), check whether the person filing is a:**

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| | | |
|:---|:---|:---|
| (a) | ☐ | Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o). |
| (b) | ☐ | Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c). |
| (c) | ☐ | Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c). |
| (d) | ☐ | Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8). |
| (e) | ☐ | An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E); |
| (f) | ☐ | An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F); |
| (g) | ☐ | A parent holding company or control person in accordance with §240.13d-1(b)(1)(ii)(G); |
| (h) | ☐ | A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C.1813); |
| (i) | ☐ | A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3); |
| (j) | ☐ | A non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J); |
| (k) | ☐ | Group, in accordance with §240.13d-1(b)(1)(ii)(K). |
| If filing as a non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J), please specify the type of institution: | If filing as a non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J), please specify the type of institution: | If filing as a non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J), please specify the type of institution: |

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Not applicable.

**Item 4.** **Ownership.**

Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

<br> I. Medica III Management Co. is the general partner of Medica III Management L.P., the general partner of each of the investments funds named in Item 2(a) above:

(a) Amount beneficially owned together with all other Reporting Persons: 3,292,250 Ordinary Shares

(b) Percent of class\*: 31.0%

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<br> (c) Number of shares as to which the person together with all other Reporting Persons has:

(i) Sole power to vote or to direct the vote: 3,292,250

(ii) Shared power to vote or to direct the vote: 0

<br> (iii) Sole power to dispose of or to direct the disposition of: 3,292,250

<br> (iv) Shared power to dispose of or to direct the disposition of: 0

<br> II. Medica III Management Co. is the general partner of each of the investment funds named in Item 2(a) above:

(a) Amount beneficially owned together with all other Reporting Persons: 3,292,250 Ordinary Shares

(b) Percent of class\*: 31.0%

<br> (c) Number of shares as to which the person together with all other Reporting Persons has:

(i) Sole power to vote or to direct the vote: 3,292,250

(ii) Shared power to vote or to direct the vote: 0

<br> (iii) Sole power to dispose of or to direct the disposition of: 3,292,250

<br> (iv) Shared power to dispose of or to direct the disposition of: 0

<br> III. Medica III Investments (International) L.P.

(a) Amount beneficially owned together with all other Reporting Persons: 3,292,250 Ordinary Shares

(b) Percent of class\*: 31.0%

<br> (c) Number of shares as to which the person together with all other Reporting Persons has:

(i) Sole power to vote or to direct the vote: 3,292,250

(ii) Shared power to vote or to direct the vote: 0

<br> (iii) Sole power to dispose of or to direct the disposition of: 3,292,250

<br> (iv) Shared power to dispose of or to direct the disposition of: 0

<br> IV. Medica III Investments (Israel) L.P.

(a) Amount beneficially owned together with all other Reporting Persons: 3,292,250 Ordinary Shares

(b) Percent of class\*: 31.0%

<br> (c) Number of shares as to which the person together with all other Reporting Persons has:

(i) Sole power to vote or to direct the vote: 3,292,250

(ii) Shared power to vote or to direct the vote: 0

<br> (iii) Sole power to dispose of or to direct the disposition of: 3,292,250

<br> (iv) Shared power to dispose of or to direct the disposition of: 0

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<br> V. Medica III Investments (S.F.) L.P.

(a) Amount beneficially owned together with all other Reporting Persons: 3,292,250 Ordinary Shares

(b) Percent of class\*: 31.0%

<br> (c) Number of shares as to which the person together with all other Reporting Persons has:

(i) Sole power to vote or to direct the vote: 3,292,250

(ii) Shared power to vote or to direct the vote: 0

<br> (iii) Sole power to dispose of or to direct the disposition of: 3,292,250

<br> (iv) Shared power to dispose of or to direct the disposition of: 0

<br> VI. Medica III Investments (P.F.) L.P.

(a) Amount beneficially owned together with all other Reporting Persons: 3,292,250 Ordinary Shares

(b) Percent of class\*: 31.0%

<br> (c) Number of shares as to which the person together with all other Reporting Persons has:

(i) Sole power to vote or to direct the vote: 3,292,250

(ii) Shared power to vote or to direct the vote: 0

<br> (iii) Sole power to dispose of or to direct the disposition of: 3,292,250

<br> (iv) Shared power to dispose of or to direct the disposition of: 0

<br> VII. Medica III Investments (Israel) (B) L.P.

(a) Amount beneficially owned together with all other Reporting Persons: 3,292,250 Ordinary Shares

(b) Percent of class\*: 31.0%

<br> (c) Number of shares as to which the person together with all other Reporting Persons has:

(i) Sole power to vote or to direct the vote: 3,292,250

(ii) Shared power to vote or to direct the vote: 0

<br> (iii) Sole power to dispose of or to direct the disposition of: 3,292,250

<br> (iv) Shared power to dispose of or to direct the disposition of: 0

<br> VIII. Poalim Medica III Investments L.P.

(a) Amount beneficially owned together with all other Reporting Persons: 3,292,250 Ordinary Shares

(b) Percent of class\*: 31.0%

<br> (c) Number of shares as to which the person together with all other Reporting Persons has:

(i) Sole power to vote or to direct the vote: 3,292,250

(ii) Shared power to vote or to direct the vote: 0

<br> (iii) Sole power to dispose of or to direct the disposition of: 3,292,250

<br> (iv) Shared power to dispose of or to direct the disposition of: 0

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<br> IX. Ehud Geller

(a) Amount beneficially owned together with all other Reporting Persons: 3,292,250 Ordinary Shares

(b) Percent of class\*: 31.0%

<br> (c) Number of shares as to which the person together with all other Reporting Persons has:

(i) Sole power to vote or to direct the vote: 0

(ii) Shared power to vote or to direct the vote: 3,292,250

<br> (iii) Sole power to dispose of or to direct the disposition of: 0

<br> (iv) Shared power to dispose of or to direct the disposition of: 3,292,250

<br> X. Batsheva Elran

(a) Amount beneficially owned together with all other Reporting Persons: 3,292,250 Ordinary Shares

(b) Percent of class\*: 31.0%

<br> (c) Number of shares as to which the person together with all other Reporting Persons has:

(i) Sole power to vote or to direct the vote: 0

(ii) Shared power to vote or to direct the vote: 3,292,250

<br> (iii) Sole power to dispose of or to direct the disposition of: 0

<br> (iv) Shared power to dispose of or to direct the disposition of: 3,292,250

\* All percentages in this Schedule 13G are based on 10,634,166 Ordinary Shares of the Issuer's issued and outstanding as of September 30, 2022.

**Item 5.** **Ownership of Five Percent or Less of a Class.**

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following: ☐.

**Item 6.** **Ownership of More Than Five Percent on Behalf of Another Person.**

Not applicable

**Item 7.** **Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.**

Not applicable.

**Item 8.** **Identification and Classification of Members of the Group.**

Not applicable.

**Item 9.** **Notice of Dissolution of Group.**

Not applicable.

**Item 10.** **Certifications.**

Not applicable.

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**SIGNATURE**

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Dated: March 2, 2023

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| | |
|:---|:---|
| MEDICA III MANAGEMENT CO | MEDICA III MANAGEMENT CO |
| By: | /s/ Ehud Geller |
| Name: | Ehud Geller |
| Title: | General Partner |
| MEDICA III MANAGEMENT L.P. | MEDICA III MANAGEMENT L.P. |
| By: Medica III Management Co., its general partner | By: Medica III Management Co., its general partner |
| By: | /s/ Ehud Geller |
| Name: | Ehud Geller |
| Title: | General Partner |
| MEDICA III MANAGEMENT CO. | MEDICA III MANAGEMENT CO. |
| MEDICA III INVESTMENTS (INTERNATIONAL) L.P. | MEDICA III INVESTMENTS (INTERNATIONAL) L.P. |
| MEDICA III INVESTMENTS (ISRAEL) L.P. | MEDICA III INVESTMENTS (ISRAEL) L.P. |
| MEDICA III INVESTMENTS (S.F.) L.P. | MEDICA III INVESTMENTS (S.F.) L.P. |
| MEDICA III INVESTMENTS (P.F.) L.P. | MEDICA III INVESTMENTS (P.F.) L.P. |
| MEDICA III INVESTMENTS (ISRAEL) (B) L.P. | MEDICA III INVESTMENTS (ISRAEL) (B) L.P. |
| POALIM MEDICA INVESTMENTS L.P. | POALIM MEDICA INVESTMENTS L.P. |
| By: Medica III Management L.P., its general partner | By: Medica III Management L.P., its general partner |
| By: Medica III Management Co., its general partner | By: Medica III Management Co., its general partner |
| By: | /s/ Ehud Geller |
| Name: | Ehud Geller |
| Title: | General Partner |
| /s/ EHUD GELLER | /s/ EHUD GELLER |
| EHUD GELLER | EHUD GELLER |

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**EXHIBITS**

Exhibit 1 – [Joint Filing Agreement pursuant to Rule 13d-1(k)(1)](https://www.sec.gov/Archives/edgar/data/1284386/000121390021009639/ea135638ex99-1_painreform.htm)

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