# EDGAR Filing Document

**Accession Number:** 0001582313
**File Stem:** 0001193125-26-152844
**Filing Date:** 2026-4
**Character Count:** 18281
**Document Hash:** 4dc49a8b0da2991ae79936c2d1b41892
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-26-152844.hdr.sgml**: 20260413

**ACCESSION NUMBER**: 0001193125-26-152844

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 17

**FILED AS OF DATE**: 20260413

**DATE AS OF CHANGE**: 20260413

**EFFECTIVENESS DATE**: 20260413

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Xenon Pharmaceuticals Inc.
- **CENTRAL INDEX KEY:** 0001582313
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 980661854
- **STATE OF INCORPORATION:** A1
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-295020
- **FILM NUMBER:** 26857837

**BUSINESS ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** 200 - 3650 GILMORE WAY
- **CITY:** BURNABY
- **PROVINCE COUNTRY:** A1
- **BUSINESS PHONE:** (604) 484-3300

**MAIL ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** 200 - 3650 GILMORE WAY
- **CITY:** BURNABY
- **PROVINCE COUNTRY:** A1

**As filed with the Securities and Exchange Commission on April 13, 2026**

**Registration Statement No. 333-**

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**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

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**FORM S-8**

**REGISTRATION STATEMENT**

***Under***

***THE SECURITIES ACT OF 1933***

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**XENON PHARMACEUTICALS INC.**

**(Exact name of registrant as specified in its charter)**

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---

| | |
|:---|:---|
| **Canada** | **98-0661854** |
| **(State or other jurisdiction of**<br>**incorporation or organization)** | **(I.R.S. Employer**<br>**Identification No.)** |

---

**3650 Gilmore Way**

**Burnaby, British Columbia V5G 4W8<br>Canada**

**(Address of principal executive offices, including zip code)**

**Amended and Restated 2025 Inducement Equity Incentive Plan**

**(Full title of the plan)**

**Thomas P. Kelly**

**Chief Financial Officer**

**Xenon Pharmaceuticals Inc.**

**3650 Gilmore Way**

**Burnaby, British Columbia V5G 4W8**

**Canada<br>(Name and address of agent for service)**

**(604) 484-3300**

**(Telephone number, including area code, of agent for service)**

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Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

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| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☒ | Accelerated filer | ☐ |
| Non-accelerated filer | ☐ | Smaller reporting company | ☐ |
| Emerging growth company | ☐ |  |  |

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If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

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**TABLE OF CONTENTS**

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| | |
|:---|:---|
|  | **<u>Page</u>** |
| [<u>Item 3. Incorporation of Documents by Reference</u>](#incorporation) | 1 |
| [<u>Item 8. Exhibits</u>](#item8) | 2 |

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[<u>Signatures</u>](#signatures)

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**EXPLANATORY NOTE**

**REGISTRATION OF ADDITIONAL SHARES PURSUANT TO GENERAL INSTRUCTION E**

This registration statement on Form S-8 (the "Registration Statement") registers an additional 275,000 common shares, without par value, of Xenon Pharmaceuticals Inc. (the "Registrant") to be issued pursuant to the Registrant's Amended and Restated 2025 Inducement Equity Incentive Plan. Accordingly, the contents of (i) the Registration Statement on Form S-8 filed by the Registrant with the Securities and Exchange Commission (the "Commission") on February 27, 2025 (File No. 333-285382); and (ii) the Registration Statement on Form S-8 filed by the Registrant with the Commission on December 1, 2025 (File No. 333-291868) (together, the "Previous Form S-8"), including periodic and other reports that the Registrant filed after the filing of the Previous Form S-8 to maintain current information about the Registrant, are incorporated herein by reference into this Registration Statement pursuant to General Instruction E to Form S-8.

**PART II**

**INFORMATION REQUIRED IN THE REGISTRATION STATEMENT**

**Item 3. Incorporation of Documents by Reference** 

The following documents previously filed with the U.S. Securities and Exchange Commission (the "**Commission**") are hereby incorporated by reference:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1)The Registrant's Annual Report on [<u>Form 10-K</u>](https://www.sec.gov/ix?doc=/Archives/edgar/data/0001582313/000119312526076650/xene-20251231.htm) for the fiscal year ended December 31, 2025, filed with the Commission on February 26, 2026;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2)All other reports filed with the Commission pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended (the "**Act**"), since the end of the fiscal year covered by the Registrant's Annual Report referred to in (1) above; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3)The description of the Registrant's common shares contained in the Registration Statement on [<u>Form 8-A12B</u>](https://www.sec.gov/Archives/edgar/data/0001582313/000119312514369146/d803267d8a12b.htm) (File No. 001-36687) filed with the Commission on October 10, 2014, pursuant to Section 12(b) of the Act, as updated by any amendment or report filed for the purpose of updating such description, including the description of the Registrant's Common Shares contained in Exhibit 4.3 to its Annual Report on Form 10-K for the fiscal year ended December 31, 2025, filed on February 26, 2026.

All documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Act, prior to the filing of a post-effective amendment which indicates that all securities registered have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference in this Registration Statement and to be part hereof from the date of filing of such documents; provided, however, that documents or information deemed to have been furnished and not filed in accordance with the rules of the Commission shall not be deemed incorporated by reference into this Registration Statement. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently filed document which also is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.

Under no circumstances will any information furnished under items 2.02 or 7.01 of Form 8-K be deemed incorporated herein by reference unless such Form 8-K expressly provides to the contrary.

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**Item 8. Exhibits** 

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| | | | | | |
|:---|:---|:---|:---|:---|:---|
| Exhibit<br>Number | &nbsp;&nbsp;**Description of Document** | **Incorporated by Reference** | **Incorporated by Reference** | **Incorporated by Reference** | **Incorporated by Reference** |
| Exhibit<br>Number | &nbsp;&nbsp;**Description of Document** | **Form** | **File No.** | **Exhibit** | **Filing Date** |
| &nbsp;&nbsp;4.1 | &nbsp;&nbsp;[<u>Specimen common share certificate of the Registrant.</u>](https://www.sec.gov/Archives/edgar/data/1582313/000119312514363909/d582812dex41.htm) | S-1/A | 333-198666 | 4.1 | 10/6/2014 |
| &nbsp;&nbsp;4.2+ | &nbsp;&nbsp;[<u>Amended and Restated 2025 Inducement Equity Incentive Plan and related form agreements.</u>](https://www.sec.gov/Archives/edgar/data/1582313/000119312526152834/xene-ex10_1.htm) | 8-K | 001-36687 | 10.1 | 4/13/2026 |
| &nbsp;&nbsp;5.1 | &nbsp;&nbsp;[<u>Opinion of Blake, Cassels & Graydon LLP.</u>](xene-ex5_1.htm) |  |  |  |  |
| &nbsp;&nbsp;23.1 | &nbsp;&nbsp;[<u>Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting Firm.</u>](xene-ex23_1.htm) |  |  |  |  |
| &nbsp;&nbsp;23.2 | &nbsp;&nbsp;[<u>Consent of KPMG LLP, Independent Registered Public Accounting Firm.</u>](xene-ex23_2.htm) |  |  |  |  |
| &nbsp;&nbsp;23.3 | &nbsp;&nbsp;[<u>Consent of Blake, Cassels & Graydon LLP (contained in Exhibit 5.1 hereto).</u>](xene-ex5_1.htm) |  |  |  |  |
| &nbsp;&nbsp;24.1 | &nbsp;&nbsp;[<u>Power of Attorney (contained on signature page hereto).</u>](#power_of_attorney) |  |  |  |  |
| &nbsp;&nbsp;107 | &nbsp;&nbsp;[<u>Filing Fee Table</u>](xene_exfilingfees.htm) |  |  |  |  |

---

+ Indicates management contract or compensatory plan, contract or arrangement.

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**SIGNATURES**

Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in Needham Heights, Massachusetts, on April 13, 2026.

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| | |
|:---|:---|
| **XENON PHARMACEUTICALS INC.** | **XENON PHARMACEUTICALS INC.** |
| By: | /s/ Thomas P. Kelly |
|  | Thomas P. Kelly |
|  | Chief Financial Officer |

---

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**POWER OF ATTORNEY**

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Ian Mortimer and Thomas P. Kelly as his and her true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities (including his or her capacity as a director and/or officer of Xenon Pharmaceuticals Inc.) to sign any or all amendments (including post-effective amendments) to this registration statement on Form S-8, as amended, and to file the same, with all exhibits thereto, and all other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agents or any of them, or his or her substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statement on Form S-8 has been signed by the following persons in the capacities and on the dates indicated.<br>

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| | | |
|:---|:---|:---|
| **Name** | **Title** | **Date** |
| /s/ Ian Mortimer | President, Chief Executive Officer and Director (Principal Executive Officer) | April 13, 2026 |
| Ian Mortimer |  |  |
| /s/ Thomas P. Kelly | Chief Financial Officer (Principal Financial and Accounting Officer) | April 13, 2026 |
| Thomas P. Kelly |  |  |
| /s/ Dawn Svoronos | Chair of the Board of Directors | April 13, 2026 |
| Dawn Svoronos |  |  |
| /s/ Gillian Cannon | Director | April 13, 2026 |
| Gillian Cannon |  |  |
| /s/ Steven Gannon | Director | April 13, 2026 |
| Steven Gannon |  |  |
| /s/ Elizabeth Garofalo | Director | April 13, 2026 |
| Elizabeth Garofalo |  |  |
| /s/ Justin Gover | Director | April 13, 2026 |
| Justin Gover |  |  |
| /s/ Patrick Machado | Director | April 13, 2026 |
| Patrick Machado |  |  |
| /s/ Gary Patou | Director | April 13, 2026 |
| Gary Patou |  |  |

---

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## Exhibit 5.1

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| | |
|:---|:---|
| &nbsp;&nbsp;![img3998686_0.gif](img3998686_0.gif) | &nbsp;&nbsp;![img3998686_1.jpg](img3998686_1.jpg) |

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**Exhibit 5.1**

April 13, 2026

Reference:191296/1

Xenon Pharmaceuticals Inc.

3650 Gilmore Way

Burnaby, BC V5G 4W8

Canada

**RE: Registration Statement on Form S-8 of Xenon Pharmaceuticals Inc. (the "Company")**

We have acted as Canadian counsel to the Company, a corporation continued under the federal laws of Canada, in connection with the Registration Statement on Form S-8 (the "**Registration Statement**") to be filed by the Company with the U.S. Securities and Exchange Commission (the "**SEC**") relating to the registration under the Securities Act of 1933, as amended, of an additional 275,000 common shares in the capital of the Company (the "**Shares**") reserved for issuance under the Company's 2025 Inducement Equity Incentive Plan, as amended and restated on November 24, 2025, and further amended April 7, 2026 (the "**Plan**").

In connection with giving this opinion, we have examined the Registration Statement (including exhibits thereto). We have also examined originals, certified or otherwise identified to our satisfaction, of such public and corporate records, certificates, instruments and other documents as we have considered necessary in order to express the opinion set out below. With respect to the accuracy of factual matters material to this opinion, we have relied upon certificates or comparable documents and representations of public officials and of officers and representatives of the Company.

In giving this opinion, we have assumed the genuineness of all signatures, the authenticity of all documents submitted to us as originals and the conformity to original documents of all documents submitted to us as copies, certified or otherwise identified to our satisfaction. We have also considered such questions of law as we have deemed relevant and necessary as a basis for the opinion hereinafter expressed.

The opinion expressed herein is limited to matters governed by the laws of the Province of British Columbia and the laws of Canada applicable therein.

Based and relying upon and subject to the foregoing, we are of the opinion that the Shares, when issued by the Company in accordance with the terms of the Plan and the agreements contemplated by the Plan, will be validly issued, fully paid and non-assessable shares in the capital of the Company.

We hereby consent to the filing of this opinion letter as an exhibit to the Registration Statement and further consent to the use of our name wherever appearing in the Registration Statement.

This opinion is effective as at the date hereof and is based upon laws in effect and facts in existence as at the date hereof. We express no opinion as to the effect of future laws or judicial decisions on the subject matter hereof, nor do we undertake any duty to modify this opinion to reflect subsequent facts or developments concerning the Company or developments in the law occurring after the date hereof.

Yours truly,

/s/ Blake, Cassels & Graydon LLP

![img3998686_2.gif](img3998686_2.gif)

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## Exhibit 23.1

**Exhibit 23.1**

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in this Registration Statement on Form S-8 of Xenon Pharmaceuticals Inc. of our report dated February 26, 2026 relating to the financial statements and the effectiveness of internal control over financial reporting, which appears in Xenon Pharmaceuticals Inc.'s Annual Report on Form 10-K for the year ended December 31, 2025.

/s/ PricewaterhouseCoopers LLP<br>Boston, MA<br>April 13, 2026

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## Exhibit 23.2

**Exhibit 23.2**

**Consent of Independent Registered Public Accounting Firm**

The Board of Directors

Xenon Pharmaceuticals Inc.

We consent to the use of our report dated February 27, 2025, on the consolidated financial statements of Xenon Pharmaceuticals Inc. ("the Entity"), which comprise the consolidated balance sheet as of December 31, 2024, the related consolidated statements of operations and comprehensive loss, shareholders' equity and cash flows for each of the years in the two-year period ended December 31, 2024, and the related notes, which is incorporated by reference in the Registration Statement on Form S-8 dated April 13, 2026 of the Entity.

/s/ KPMG LLP

Chartered Professional Accountants

April 13, 2026

Vancouver, Canada

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## Ex-Filing

?xml version='1.0' encoding='ASCII'? EX-FILING FEES

**Exhibit 107**

**Calculation of** Filing Fee Tables

**<u>Form</u>** S-8(Form Type)

Xenon Pharmaceuticals Inc.

(Exact Name of Registrant as Specified in its Charter)

<u>Table 1: Newly Registered Securities</u>

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| **Security Type** | **Security Class Title** | **Fee Calculation Rule** | **Amount Registered** <sup>(1)</sup> | **Maximum Aggregate Offering Price** | **Fee Rate** | **Amount of Registration Fee** |
| Equity | Common Shares, no par value per share | Other | 275000<br>$58.40 <sup>(2)</sup> | $16060000 | $138.10 per $1,000,000<br>| $2217.89 |
| **Total Offering Amounts** | **Total Offering Amounts** | **Total Offering Amounts** | **Total Offering Amounts** | $16060000 |  | $2217.89 |
| **Total Fee Offsets** | **Total Fee Offsets** | **Total Fee Offsets** | **Total Fee Offsets** |  |  |  |
| **Net Fee Due** | **Net Fee Due** | **Net Fee Due** | **Net Fee Due** |  |  | $2217.89 |

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(1)Pursuant to Rule 416(a) of the Securities Act of 1933, as amended (the "**Securities Act**"), this Registration Statement shall also cover any additional common shares of the Registrant that become issuable under the Amended and Restated 2025 Inducement Equity Incentive Plan (the "**Amended and Restated 2025 Plan**") by reason of any share dividend, share split, recapitalization or other similar transaction effected without receipt of consideration that increases the number of the Registrant's outstanding common shares.

&nbsp;&nbsp;&nbsp;&nbsp;(2)Estimated in accordance with Rules 457(c) and 457(h) of the Securities Act solely for the purpose of calculating the registration fee on the basis of $58.40 per share, the average of the high and low prices of the Registrant's common shares as reported on The Nasdaq Global Market on April 10, 2026.

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