# EDGAR Filing Document

**Accession Number:** 0001614744
**File Stem:** 0001213900-23-009141
**Filing Date:** 2023-2
**Character Count:** 31165
**Document Hash:** 2b2b348da1820d48362bb2262636cc21
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001213900-23-009141.hdr.sgml**: 20230208

**ACCESSION NUMBER**: 0001213900-23-009141

**CONFORMED SUBMISSION TYPE**: 6-K

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20230208

**FILED AS OF DATE**: 20230208

**DATE AS OF CHANGE**: 20230208

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** PURPLE BIOTECH LTD.
- **CENTRAL INDEX KEY:** 0001614744
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** L3
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 6-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-37643
- **FILM NUMBER:** 23597064

**BUSINESS ADDRESS:**
- **STREET 1:** 4 OPPENHEIMER STREET
- **STREET 2:** SCIENCE PARK
- **CITY:** REHOVOT
- **STATE:** L3
- **ZIP:** 7670104
- **BUSINESS PHONE:** 97239333121

**MAIL ADDRESS:**
- **STREET 1:** 4 OPPENHEIMER STREET
- **STREET 2:** SCIENCE PARK
- **CITY:** REHOVOT
- **STATE:** L3
- **ZIP:** 7670104

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Kitov Pharma Ltd.
- **DATE OF NAME CHANGE:** 20180125

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Kitov Pharmaceuticals Holdings Ltd.
- **DATE OF NAME CHANGE:** 20140724

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**FORM 6-K**

**Report of Foreign Private Issuer**

**Pursuant to Rule 13a-16 or 15d-16**

**of the Securities Exchange Act of 1934**

For the month of February 2023

Commission File Number: 001-37643

**PURPLE BIOTECH LTD.**

(Translation of registrant's name into English)

**4 Oppenheimer Street, Science Park, Rehovot 7670104, Israel**

(Address of principal executive offices)

Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.

Form 20-F ☒ Form 40-F ☐

Indicate by check mark if the Registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1): ☐

Indicate by check mark if the Registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7): ☐

On February 8, 2023, Purple Biotech Ltd. (the "Company" or the "Registrant") issued a press release, "Purple Biotech Reports Fourth Quarter and Full-Year 2022 Financial Results", which is attached hereto as Exhibit 99.1.

---

| | |
|:---|:---|
| **Exhibit** |  |
| 99.1 | [Purple Biotech Reports Fourth Quarter and Full-Year 2022 Financial Results](ea172962ex99-1_purplebiotech.htm) |

---

**Incorporation by Reference**

This Report on Form 6-K, including all exhibits attached hereto, is hereby incorporated by reference into each of the Registrant's Registration Statement on [Form S-8](http://www.sec.gov/Archives/edgar/data/1614744/000114420416103812/v440298_s8.htm) filed with the Securities and Exchange Commission on May 20, 2016 (Registration file number 333-211478), the Registrant's Registration Statement on [Form S-8](http://www.sec.gov/Archives/edgar/data/1614744/000121390017006184/fs82017_kitovpharma.htm) filed with the Securities and Exchange Commission on June 6, 2017 (Registration file number 333-218538), the Registrant's Registration Statement on [Form F-3](http://www.sec.gov/Archives/edgar/data/1614744/000121390018009254/ff32018_kitovpharma.htm), as amended, originally filed with the Securities and Exchange Commission on July 16, 2018 (Registration file number 333-226195), the Registrant's Registration Statement on [Form S-8](http://www.sec.gov/Archives/edgar/data/1614744/000121390019005134/fs82019_kitovpharmaltd.htm) filed with the Securities and Exchange Commission on March 28, 2019 (Registration file number 333-230584), the Registrant's Registration Statement on [Form F-3](http://www.sec.gov/Archives/edgar/data/1614744/000121390019018149/ff32019_kitovpharma.htm) filed with the Securities and Exchange Commission on September 16, 2019 (Registration file number 333-233795), the Registrant's Registration Statement on [Form F-3](http://www.sec.gov/Archives/edgar/data/1614744/000121390019025127/ff3dec2019_kitovpharma.htm) filed with the Securities and Exchange Commission on December 2, 2019 (Registration file number 333-235327), the Registrant's Registration Statement on [Form F-3](http://www.sec.gov/Archives/edgar/data/1614744/000121390020012007/ea121429-f3_kitovpharma.htm) filed with the Securities and Exchange Commission on May 13, 2020 (Registration file number 333- 238229), the Registrant's Registration Statement on [Form S-8](http://www.sec.gov/Archives/edgar/data/1614744/000121390020012852/ea122048-s8_kitovpharma.htm) filed with the Securities and Exchange Commission on May 18, 2020 (Registration file number 333-238481), each of the Registrant's Registration Statements on Form F-3 filed with the Securities and Exchange Commission on July 10, 2020 (Registration file numbers [333-239807](http://www.sec.gov/Archives/edgar/data/1614744/000121390020017224/ea123998-f3_kitovpharma.htm) and [333-233793](http://www.sec.gov/Archives/edgar/data/1614744/000121390020017228/ea124005-posam_kitovpharma.htm)) and the Registrant's Registration Statement on [Form S-8](http://www.sec.gov/Archives/edgar/data/1614744/000121390022017815/ea157934-s8_purplebiotech.htm) filed with the Securities and Exchange Commission on April 4, 2022 (Registration file number 333-264107), to be a part thereof from the date on which this report is submitted, to the extent not superseded by documents or reports subsequently filed or furnished.

**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

---

| | | |
|:---|:---|:---|
| February 8, 2023 | **PURPLE BIOTECH LTD.** | **PURPLE BIOTECH LTD.** |
|  | By: | */s/ Lior Fhima* |
|  |  | Lior Fhima |
|  |  | Chief Financial Officer |

---

## Exhibit 99.1

**Exhibit 99.1**

**Purple Biotech Reports Fourth Quarter and Full-Year 2022 Financial Results**

*Expands pipeline with acquisition of new tri-specific antibodies* 

*Data readouts for two lead clinical programs expected in 2023* 

**REHOVOT, Israel, February 8, 2023** – (GLOBE NEWSWIRE) Purple Biotech Ltd. ("Purple Biotech" or "the Company") (NASDAQ/TASE: PPBT), a clinical-stage company developing first-in-class, effective and durable therapies that harness the power of the tumor microenvironment to overcome tumor immune evasion and drug resistance, today announced financial results for the year and the three months ended December 31, 2022.

"We are reporting our 2022 financial results which are in line with our plans," said Gil Efron, Chief Executive Officer of Purple Biotech. "Our end-of-year balance sheet is strong and enables us to execute our strategic plan. We started 2023 by acquiring an innovative platform of tri-specific antibodies and we are looking forward to data readouts from both of our ongoing clinical programs. I believe that our diverse promising pipeline is a good foundation for building a strong and sustainable oncology company.

"During 2022 we enhanced the CM24 trial, reprioritizing its study arms and expanding the design to randomize the study – a good example of the thoughtful, flexible approach we take to drug development. For NT219 we advanced the dose escalation Phase 1 study, both as monotherapy and in combination with cetuximab, and have reached the 50mg/kg dose level in both arms. We anticipate reporting clinical data for both CM24 and NT219 during this coming year. We just completed the acquisition of Immunorizon, thus securing a valuable portfolio of multi-specific antibodies that are highly complementary to our existing clinical compounds targeting the tumor microenvironment."

**<u>Business Development, Post-Fiscal 2022</u>**

● *Immunorizon Acquisition Expands Company Pipeline* 

After the close of the 2022 fiscal year, Purple Biotech expanded its product pipeline through the acquisition of private company Immunorizon Ltd.. This acquisition, signed on February 2, 2023, brings a portfolio of potential multi-specific T and NK cell engager oncology therapies that selectively activate the immune response within the tumor microenvironment. The lead asset targets the antigen 5T4, activating both T and NK cells to mount a powerful immune system response against cancer cells; importantly, the compound includes a cleavable capping technology that has the potential to widen the therapeutic index. The acquisition provides Purple Biotech with a technology platform for tri-specific antibody compounds and offers the potential to further expand to additional targets. The Company anticipates bringing the first of these assets to IND filing in approximately two years.

● *Collaboration with Mor Research Applications* 

Also after the close of fiscal 2022, Purple Biotech announced on January 3, 2023, a research collaboration with Mor Research Applications, the technology transfer subsidiary of Clalit Healthcare Services. The agreement gives Purple first access to pre-clinical oncology product candidates owned by Mor, including the option to fund early development, in-license selected drug assets and pursue their development and commercialization.

**<u>Corporate Updates for 2022</u>**

***Clinical Studies***

 ****

● *CM24 Study Design Update (PDAC)* 

The Company has amended the Phase 2 clinical trial evaluating the combination of its monoclonal antibody CM24, a potential new first-in-class mAb that blocks the immune checkpoint CEACAM1 from supporting tumor immune evasion and survival, with the PD-1 inhibitor (nivolumab) plus chemotherapy for patients with 2L metastatic pancreatic cancer (PDAC). The clinical trial design has been amended to randomize the study comparing CM24+nivolumab+standard-of-care (SoC) chemotherapy against SoC chemotherapy. The study is ongoing, with patients being treated in a run-in portion of the study, which includes up to 18 patients followed by approximately 60 patients in the randomized part of the study. An interim analysis is expected in the second half of 2023 and a topline report on the overall study at the end of 2024.

● *CM24 Presentation at AACR Special Conference* 

At the American Association of Cancer Research (AACR) Special Conference: Cancer Metastasis in November, Purple Biotech presented data that provide a rationale for an innovative mechanism of action for CM24. "CM24, a Novel Anti-CEACAM1 mAb, Suppresses Neutrophil Extracellular Trap (NET)-Induced Migration and Metastasis of Cancer Cells" focused on the compound's activity against neutrophil extracellular traps.

● *NT219 Study Progress (SCCHN)* 

In the monotherapy arm of the Phase 1/2 clinical trial for NT219, participants are being treated at the 50 mg/kg dose level, which is the last dose to be evaluated for monotherapy treatment. In the combination arm of NT219 + cetuximab, we are now recruiting for the 50 mg/kg dose of NT219. As this trial progresses, Purple Biotech expects to reach the recommended Phase 2 dose (RP2D) this year and enter into the Phase 2 of this study thereafter.

 **

***Management Changes***

 **

● In July, Gil Efron transitioned from serving as President and Chief Financial Officer to the Chief Executive Officer position when Isaac Israel stepped down as CEO, while retaining his membership on the Board of Directors and as an advisor to the Company. The Company also welcomed Lior Fhima as Chief Financial Officer in November.

**<u>Financial Results for the Year Ended December 31, 2022</u>**

**Research and Development Expenses** were $16.3 million, an increase of $4.5 million, or 38.1%, compared to $11.8 million in the same period of 2021. The increase was mainly due to expenses related to the ongoing NT219 and CM24 clinical trials, including CMC expenses.

**Selling, General and Administrative Expenses** were $6.3 million, compared to $6.1 million in the same period of 2021, an increase of $0.2 million.

**Operating Loss** was $22.6 million, an increase of $4.7 million, or 26.3%, compared to $17.9 million in the same period of 2021. The increase was mainly due to the increase in research and development expenses.

On a non-IFRS basis (as reconciled below), **adjusted operating loss** was $20.2 million, an increase of $4.3 million, compared to $15.9 million in the same period of 2021, mainly due to the increased expenses for clinical studies and manufacturing of drugs for these studies.

**Net Loss** for 2022 was $21.8 million, or $1.20 per basic and diluted share, compared to a net loss of $18.5 million, or $1.01 per basic and diluted share, in 2021. The increase in net loss was mainly due to $4.5 million in operating expenses, offset by a decrease of $0.6 million in loss from discontinued operation and an increase in finance income of $0.5 million. **Adjusted net loss** for the year was $19.6 million, an increase from $15.7 million in the full year of 2021.

As of December 31, 2022, Purple Biotech had cash and cash equivalents, short- and long-term deposits of $31.7 million, compared to $47.4 million on December 31, 2021. This cash position provides a cash runway into the second half of 2024.

During the year ended December 31, 2022, the Company sold, under the Open Market Sale Agreement with Jefferies LLC, approximately 543 thousand ADSs, at an average price of $2.65 per ADS. Net proceeds to the Company were approximately $1.3 million, net of issuance expenses.

**<u>Financial Results for the three Months Ended December 31, 2022</u>**

**Research and Development Expenses** were $4.8 million, an increase of $1.6 million, or 50%, compared to $3.2 million in the same period of 2021. The increase was mainly due to expenses related to the CM24 and NT219 clinical trials and CMC expenses.

**Selling, General and Administrative Expenses** were $1.8 million, compared to $1.5 million in the same period of 2021, an increase of $0.3 million.

**Operating Loss** was $6.6 million, an increase of $1.9 million, or 40.4%, compared to $4.7 million in the same period of 2021.

On a non-IFRS basis (as reconciled below), **adjusted operating loss** was $5.8 million, an increase of $1.4 million, compared to $4.4 million in the same period of 2021, mainly to increase in R&D expenses offset by other income.

**Net Loss** for the three months ended December 31, 2022 was $6.0 million, or $0.33 per basic and diluted share, compared to a net loss of $5.1 million, or $0.29 per basic and diluted, in the three months ended December 31, 2021. The increase in net loss was mainly due to an increase in R&D expenses offset by other income and increase in financial income. **Adjusted net loss** for the three months ended December 31, 2022 was $5.4 million, an increase from $4.4 million in the same period of 2021.

**About Purple Biotech**

Purple Biotech Ltd. (NASDAQ/TASE: PPBT) is a clinical-stage company developing first-in-class therapies that seek to overcome tumor immune evasion and drug resistance. The Company's oncology pipeline includes NT219, CM24 and IM1240. NT219 is a dual inhibitor, novel small molecule that simultaneously targets IRS1/2 and STAT3. In a Phase 1/2 study of NT219, the Company is currently advancing it in a dose escalation as a monotherapy treatment of solid tumors, and in a dose escalation in combination with cetuximab for the treatment of recurrent and metastatic squamous cell carcinoma of the head and neck (SCCHN) or colorectal adenocarcinoma (CRC). These studies will be followed by an expansion phase of NT219 at its recommended Phase 2 level in combination with cetuximab in patients with recurrent and metastatic SCCHN. CM24 is a humanized monoclonal antibody that blocks CEACAM1, an immune checkpoint protein that supports tumor immune evasion and survival through multiple pathways. The Company is advancing CM24 as a combination therapy with anti-PD-1 checkpoint inhibitors in a Phase 2 study for the treatment of pancreatic ductal adenocarcinoma (PDAC). The Company has entered into a clinical collaboration agreement with Bristol Myers Squibb for the Phase 2 clinical trials to evaluate the combination of CM24 with the PD-1 inhibitor nivolumab in addition to chemotherapy. IM1240 is a preclinical, conditionally-activated tri-specific antibody that engages both T cells and NK cells to mount a strong, localized immune response within the tumor microenvironment. The third arm specifically targets the Tumor Associated Antigen (TAA) 5T4 that is expressed in a variety of solid tumors and is correlated with advanced disease, increased invasiveness and poor clinical outcomes. IM1240 has a cleavable capping technology that confines the compound's therapeutic activity to the local tumor microenvironment, and thereby potentially increases the anticipated therapeutic window in patients. The Company's corporate headquarters are located in Rehovot, Israel. For more information, please visit https://purple-biotech.com/.

**Forward-Looking Statements and Safe Harbor Statement** 

Certain statements in this press release that are forward-looking and not statements of historical fact are forward-looking statements within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements include, but are not limited to, statements that are not statements of historical fact, and may be identified by words such as "believe", "expect", "intend", "plan", "may", "should", "could", "might", "seek", "target", "will", "project", "forecast", "continue" or "anticipate" or their negatives or variations of these words or other comparable words or by the fact that these statements do not relate strictly to historical matters. You should not place undue reliance on these forward-looking statements, which are not guarantees of future performance. Forward-looking statements reflect our current views, expectations, beliefs or intentions with respect to future events, and are subject to a number of assumptions, involve known and unknown risks, many of which are beyond our control, as well as uncertainties and other factors that may cause our actual results, performance or achievements to be significantly different from any future results, performance or achievements expressed or implied by the forward-looking statements. Important factors that could cause or contribute to such differences include, among others, risks relating to: the expected benefits, synergies and costs of the transaction; management plans relating to the transaction; the potential future financial impact of the transaction; and any assumptions underlying any of the foregoing; the expected timing of the completion of the transaction and the parties' ability to complete the transaction; the plans, strategies and objectives of management for future operations; product development for NT219 and CM24 as well as Immunorizon Ltd.'s portfolio of investigational tri-specific antibody compounds to be acquired; the process by which such early stage therapeutic candidates could potentially lead to an approved drug product is long and subject to highly significant risks, particularly with respect to a joint development collaboration; the fact that drug development and commercialization involves a lengthy and expensive process with uncertain outcomes; our ability to successfully develop and commercialize our pharmaceutical products; the expense, length, progress and results of any clinical trials; the impact of any changes in regulation and legislation that could affect the pharmaceutical industry; the difficulty in receiving the regulatory approvals necessary in order to commercialize our products; the difficulty of predicting actions of the U.S. Food and Drug Administration or any other applicable regulator of pharmaceutical products; the regulatory environment and changes in the health policies and regimes in the countries in which we operate; the uncertainty surrounding the actual market reception to our pharmaceutical products once cleared for marketing in a particular market; the introduction of competing products; patents obtained by competitors; dependence on the effectiveness of our patents and other protections for innovative products; our ability to obtain, maintain and defend issued patents; the commencement of any patent interference or infringement action against our patents, and our ability to prevail, obtain a favorable decision or recover damages in any such action; and the exposure to litigation, including patent litigation, and/or regulatory actions, and other factors that are discussed in our Annual Report on Form 20-F for the year ended December 31, 2021 and in our other filings with the U.S. Securities and Exchange Commission ("SEC"), including our cautionary discussion of risks and uncertainties under "Risk Factors" in our Registration Statements and Annual Reports. These are factors that we believe could cause our actual results to differ materially from expected results. Other factors besides those we have listed could also adversely affect us. Any forward-looking statement in this press release speaks only as of the date which it is made. We disclaim any intention or obligation to publicly update or revise any forward-looking statement or other information contained herein, whether as a result of new information, future events or otherwise, except as required by applicable law. You are advised, however, to consult any additional disclosures we make in our reports to the SEC, which are available on the SEC's website, https://www.sec.gov.

**CONTACTS:**

**Company Contact:**

Lior Fhima

Chief Financial Officer

IR@purple-biotech.com

**Media Inquiries:**

Harriet Ullman<br> Vice President, Public Relations and Product Communications<br> LaVoieHealthScience<br> hullman@lavoiehealthscience.com

**Purple Biotech Ltd**.

**Consolidated Unaudited Statements of Financial Positions**

---

| | | |
|:---|:---|:---|
|  | **As of December 31,** | **As of December 31,** |
|  | **2022** | **2021** |
|  | **USD<br> thousands** | **USD<br> thousands** |
| **Current assets** |  |  |
| Cash and cash equivalents | **15030** | 10890 |
| Short term deposits | **16652** | 36310 |
| Other investments | **431** |  |
| Other current assets | **1143** | 1273 |
| **Total current assets** | **33256** | 48473 |
| **Non-current assets** |  |  |
| Other investments |  | 187 |
| Right to use assets | **467** | 619 |
| Fixed assets, net | **215** | 277 |
| Long term deposits | **-** | 160 |
| Intangible assets | **20684** | 20482 |
| **Total non – current assets** | **21366** | 21725 |
| **Total assets** | **54622** | 70198 |
| **Current liabilities** |  |  |
| Lease liability - short term | **194** | 199 |
| Accounts payable | **2132** | 1473 |
| Other payables | **4732** | 2578 |
| **Total current liabilities** | **7058** | 4250 |
| **Non-current liabilities** |  |  |
| Lease liability | **321** | 550 |
| Post-employment benefit liabilities | **145** | 292 |
| **Total non-current liabilities** | **466** | 842 |
| **Equity** |  |  |
| Share capital, no par value | **-** |  |
| Share premium | **126409** | 123951 |
| Receipts on account of warrants | **28017** | 28017 |
| Capital reserve for share based payment | **10164** | 8862 |
| Capital reserve from transactions with related parties | **761** | 761 |
| Capital reserve from hedging | **(6)** |  |
| Capital reserve from transactions with non-controlling interest | **(859)** | (859) |
| Accumulated loss | **(117575)** | (95905) |
| Equity attributable to owners of the Company | **46911** | 64827 |
| Non-controlling interest | **187** | 279 |
| **Total equity** | **47098** | 65106 |
| **Total liabilities and equity** | **54622** | 70198 |

---

**Purple Biotech Ltd.**

**Consolidated Unaudited Statements of Operations**

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **For the year ended** | **For the year ended** | **For the three months ended** | **For the three months ended** |
|  | **December 31,** | **December 31,** | **December 31,** | **December 31,** |
|  | **2022** | **2021** | **2022** | **2021** |
|  | **USD<br> thousands** | **USD<br> thousands** | **USD<br> thousands** | **USD<br> thousands** |
| Revenues | **-** | - | **-** | - |
| Research and development expenses | **16320** | 11827 | **4820** | 3245 |
| Sales, general and administrative expenses | **6283** | 6107 | **1781** | 1494 |
| Operating loss | **22603** | 17934 | **6601** | 4739 |
| Finance expenses | **126** | 212 | **18** | 69 |
| Finance income | **(969)** | (320) | **(576)** | (56) |
| **Finance (income) expense, net** | **(843)** | (108) | **(558)** | 13 |
| **Loss for the period from continuing operations** | **21760** | 17826 | **6043** | 4752 |
| Loss from discontinued operation | **-** | 642 | **-** | 354 |
| **Loss for the period** | 21760 | 18468 | 6043 | 5106 |
| **Other Comprehensive Loss:** |  |  |  |  |
| **Items that will be transferred to profit or loss:** |  |  |  |  |
| Loss from cash flow hedges | (6) | - | 11 | - |
| **Total comprehensive loss for the period** | 21766 | 18468 | 6032 | 5106 |
| **Loss attributable to:** |  |  |  |  |
| Owners of the Company | **21668** | 18384 | **6011** | 5072 |
| Non-controlling interests | **92** | 84 | **32** | 34 |
|  | **21760** | 18468 | **6043** | 5106 |
| **Total comprehensive loss attributable to** |  |  |  |  |
| Owners of the Company | **21674** | 18384 | **6000** | 5072 |
| Non-controlling interests | **92** | 84 | **32** | 34 |
|  | **21766** | 18468 | **6032** | 5106 |
| **Loss per share date** |  |  |  |  |
| **Continuing operations** |  |  |  |  |
| Basic and diluted loss per ADS - USD | **1.20** | 1.01 | **0.33** | 0.44 |
| Number of ADSs used in calculation | **18081087** | 17568036 | **18389230** | 17733554 |
| **Discontinued operation** |  |  |  |  |
| Basic and diluted loss (profit) per ADS – USD | **-** | 0.04 | **-** | 0.02 |
| Number of ADSs used in calculation | **-** | 17568036 | **-** | 17733554 |

---

**Purple Biotech Ltd.**

**Consolidated Unaudited Statements of Cash Flow**

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **For the year ended** | **For the year ended** | **For the three months ended** | **For the three months ended** |
|  | **December 31,** | **December 31,** | **December 31,** | **December 31,** |
|  | **2022** | **2021** | **2022** | **2021** |
|  | **USD<br> thousands** | **USD<br> thousands** | **USD<br> thousands** | **USD<br> thousands** |
| **Cash flows from operating activities from continuing operation:** |  |  |  |  |
| Loss for the period from continuing operation | **(21760)** | (17826) | **(6043)** | (4752) |
| **Adjustments:** |  |  |  |  |
| Depreciation | **201** | 231 | **50** | 61 |
| Finance expense (income), net | **(843)** | (108) | **(558)** | 13 |
| Share-based payments | **2412** | 2082 | **839** | 305 |
|  | **(19990)** | (15621) | **(5712)** | (4373) |
| **Changes in assets and liabilities:** |  |  |  |  |
| Changes in other current assets | **313** | (316) | **437** | (121) |
| Changes in accounts payable | **799** | 266 | **(735)** | (275) |
| Changes in other payables | **2132** | 573 | **1637** | 1199 |
| Changes in post-employment benefit liabilities | **11** | 27 | **159** | 27 |
|  | **3255** | 550 | **1498** | 830 |
| **Net cash used in operating activities from continuing operation** | **(16735)** | (15071) | **(4214)** | (3543) |
| **Cash flows from investing activities from continuing operation:** |  |  |  |  |
| Acquisition of intangible asset | **(202)** |  | **-** |  |
| Decrease in deposits | **19818** | 13162 | **7999** | 4997 |
| Interest received | **324** | 359 | **-** | 62 |
| Acquisition of fixed assets | **(26)** | (115) | **-** | - |
| **Net cash provided by investing activities from continuing operation** | **19914** | 13406 | **7999** | 5059 |
| **Cash flows from financing activities from continuing operation:** |  |  |  |  |
| Proceeds from issuance of ADSs | **1498** | 564 | **186** | 564 |
| ADS issuance expenses paid | **(152)** | (24) | **(38)** | (23) |
| Proceeds from exercise of warrants | **-** | 1200 | **-** |  |
| Repayment of lease liability | **(165)** | (153) | **(41)** | (41) |
| Interest paid | **(67)** | (75) | **(18)** | (21) |
| **Net cash provided by financing activities from continuing operation** | **1114** | 1512 | **89** | 479 |

---

**Purple Biotech Ltd.**

**Consolidated Unaudited Statements of Cash Flow (cont'd)**

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **For the year ended** | **For the year ended** | **For the three months ended** | **For the three months ended** |
|  | **December 31,** | **December 31,** | **December 31,** | **December 31,** |
|  | **2022** | **2021** | **2022** | **2021** |
|  | **USD<br> thousands** | **USD<br> thousands** | **USD<br> thousands** | **USD<br> thousands** |
| **Cash flows in respect of discontinued operation as follows:** |  |  |  |  |
| Net cash used in operating activities | **-** | (374) | **-** | (374) |
| Net cash from investing activities | **-** |  | **-** |  |
| Net cash from financing activities | **-** | - | **-** | - |
| Net cash used in discontinued operation | **-** | (374) | **-** | (374) |
| **Net increase (decrease) in cash and cash equivalents** | **4293** | (333) | **3874** | 1785 |
| **Cash and cash equivalents at the beginning of the period** | **10890** | 11247 | **11074** | 9117 |
| **Effect of translation adjustments on cash and equivalents** | **(153)** | (24) | **82** | (12) |
| **Cash and cash equivalents at end of the period** | **15030** | 10890 | **15030** | 10890 |

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**Purple Biotech Ltd**.

**Reconciliation of Non-IFRS financial Results**

**Reconciliation of Adjusted Operating Loss**

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| | | | | |
|:---|:---|:---|:---|:---|
|  | **For the year ended** | **For the year ended** | **For the three months ended** | **For the three months ended** |
|  | **December 31,** | **December 31,** | **December 31,** | **December 31,** |
|  | **2022** | **2021** | **2022** | **2021** |
|  | **USD<br> thousands** | **USD<br> thousands** | **USD<br> thousands** | **USD<br> thousands** |
| Operating loss for the year | **22603** | 17934 | **6601** | 4739 |
| Less ESOP expenses | **(2412)** | (2082) | **(839)** | (305) |
|  | **20191** | 15852 | **5762** | 4434 |

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**Reconciliation of Adjusted Net Loss**

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| | | | | |
|:---|:---|:---|:---|:---|
|  | **For the year ended** | **For the year ended** | **For the three months ended** | **For the three months ended** |
|  | **December 31,** | **December 31,** | **December 31,** | **December 31,** |
|  | **2022** | **2021** | **2022** | **2021** |
|  | **USD<br> thousands** | **USD<br> thousands** | **USD<br> thousands** | **USD<br> thousands** |
| Net loss for the year | **21760** | 18468 | **6043** | 5106 |
| Less warrant expenses | **-** |  | **-** |  |
| Less ESOP expenses | **(2412)** | (2082) | **(839)** | (305) |
| Less (loss) from discontinued operation | **-** | (642) | **-** | (354) |
| Less finance income from financial instruments | **244** | - | **244** | - |
|  | **19592** | 15744 | **5448** | 4447 |

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