# EDGAR Filing Document

**Accession Number:** 0001121404
**File Stem:** 0001193125-23-085074
**Filing Date:** 2023-3
**Character Count:** 26259
**Document Hash:** d66af306cbb56c1a86431219d4208ef4
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-23-085074.hdr.sgml**: 20230330

**ACCESSION NUMBER**: 0001193125-23-085074

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 5

**FILED AS OF DATE**: 20230330

**DATE AS OF CHANGE**: 20230330

**EFFECTIVENESS DATE**: 20230330

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Sanofi
- **CENTRAL INDEX KEY:** 0001121404
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 133529324
- **STATE OF INCORPORATION:** I0
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-270976
- **FILM NUMBER:** 23779308

**BUSINESS ADDRESS:**
- **STREET 1:** 46 AVENUE DE LA GRANDE ARMEE
- **CITY:** PARIS
- **STATE:** I0
- **ZIP:** 75017
- **BUSINESS PHONE:** 33153774400

**MAIL ADDRESS:**
- **STREET 1:** 46 AVENUE DE LA GRANDE ARMEE
- **CITY:** PARIS
- **STATE:** I0
- **ZIP:** 75017

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** SANOFI-AVENTIS
- **DATE OF NAME CHANGE:** 20040826

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** SANOFI SYNTHELABO SA
- **DATE OF NAME CHANGE:** 20010104

**As filed with the Securities and Exchange Commission on March 30, 2023** 

**Registration No. 333-** 

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**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**Washington, D.C. 20549** 

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**FORM S-8** 

**REGISTRATION STATEMENT** 

***UNDER***

***THE SECURITIES ACT OF 1933***

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## SANOFI
**(Exact name of Registrant as specified in its charter)** 

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---

| | |
|:---|:---|
| **Republic of France** | **Not Applicable** |
| **(State or other jurisdiction of**<br> **incorporation or organization)** | **(I.R.S. Employer**<br> **Identification Number)** |

---

**46, avenue de la Grande Armée, 75017 Paris, France** 

**(Address of Registrant's principal executive offices)** 

**ACTION 2023 SHAREHOLDING PLAN** 

**(Full title of the plan)** 

**Debora C. Pellicano** 

**Vice President and Chief Financial Officer** 

**Sanofi U.S. Services Inc.** 

**55 Corporate Drive** 

**Bridgewater, New Jersey 08807** 

**Tel. No. +1 (908) 981-5000** 

**(Name, address and telephone number of agent for service)** 

***Copies to:***

**John J. Cannon III, Esq.** 

**Shearman & Sterling LLP** 

**599 Lexington Ave.** 

**New York, NY 10022** 

**(212) 848-4000** 

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Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See definitions of "large accelerated filer," "accelerated filer," "small reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

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| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☒ | Accelerated filer | ☐ |
| Non-accelerated filer | ☐ | Smaller reporting company | ☐ |
|  |  | Emerging growth company | ☐ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

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**Part I** 

**INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS** 

The information required by Item 1 and Item 2 of Part I of Form S-8 is omitted from this filing in accordance with Rule 428 under the Securities Act and the introductory note to Part I of Form S-8. The documents containing the information specified in Part I will be delivered to the participants in the plan covered by this Registration Statement as required by Rule 428(b)(1).

**Part II** 

**INFORMATION REQUIRED IN THE REGISTRATION STATEMENT** 

**Item 3. Incorporation of Documents by Reference.** 

This Registration Statement on Form S-8 hereby incorporates by reference the contents of the following reports of the Registrant filed with, or furnished to, the Securities and Exchange Commission (the "Commission") pursuant to the Securities Exchange Act of 1934, as amended (the "Exchange Act"). All documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the filing of a post-effective amendment indicating that all securities offered have been sold or that deregisters all securities then remaining unsold shall be deemed to be incorporated by reference in this Registration Statement and to be part hereof from the date of filing of such document incorporated by reference. Statements contained in the foregoing documents incorporated by reference shall be deemed to be modified or superseded hereby to the extent that statements contained in the Prospectus, or in any subsequently filed documents that are amendments hereto or that are incorporated herein by reference, shall modify or replace such statements:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) The Registrant's Annual Report on Form 20-F for the year ended
December 31, 2022, as filed with the Commission on February 24, 2023 (Commission File No. 001-31368) (the "Form 20-F");

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) The Reports on Form 6-K furnished by the Registrant to the Commission
pursuant to Section 13(a) or 15(d) of the Exchange Act on March 6, 2023, March 13, 2023 and March 23, 2023 (Commission file No. 001-31368).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) The description of securities registered under Section 12 of the Exchange Act included as Exhibit 2.2 to
the Form 20-F.

**Item 4. Description of Securities.** 

Not applicable.

**Item 5. Interests of Named Experts and Counsel.** 

Alexandra Roger, Head of Securities Law and Capital Markets at the Registrant, has given her opinion about certain legal matters affecting the securities registered under this Registration Statement. Ms. Roger owns, or may have the right to acquire, the Registrant's Ordinary Shares and/or American Depository Shares.

**Item 6. Indemnification of Directors and Officers.** 

The French Commercial Code prohibits provisions of corporate articles of associations that limit the liability of directors. However, if a director is sued by a third party and ultimately prevails in the litigation on all counts but is nevertheless required to bear attorneys' fees and costs, the director may be reimbursed for those fees and costs pursuant to an indemnification arrangement.

Under French law a company may purchase directors and officers insurance for all or part of the members of its management. A French corporation is responsible to third parties for the consequences of the decisions of its board of directors. However, if those decisions qualify as mismanagement, the relevant member of the board of directors may have to fully or partly indemnify the company. Sanofi has purchased insurance for all of its directors and officers.

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**Item 7. Exemption from Registration Claimed.** 

Not applicable.

**Item 8. Exhibits.** 

See Exhibit Index.

**Item 9. Undertakings.** 

The undersigned Registrant hereby undertakes:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this
Registration Statement:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) To include any prospectus required by Section 10(a)(3) of the Securities Act;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) To reflect in the prospectus any facts or events arising after the effective date of the Registration Statement
(or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this Registration Statement; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) To include any material information with respect to the plan of distribution not previously disclosed in the
registration statement or any material change to such information in the Registration Statement;

*provided*, *however*, that paragraphs (i) and (ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or 15(d) of the Exchange Act that are incorporated by reference in the Registration Statement;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment
shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial *bona fide* offering thereof; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3) To remove from registration by means of a post-effective amendment any of the securities being registered which
remain unsold at the termination of the offering.

The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial *bona fide* offering thereof.

The undersigned Registrant further undertakes that, insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.

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**EXHIBIT INDEX** 

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| | |
|:---|:---|
| **Exhibit No.** | **Description of Document** |
| 4.1 | [Articles of association (statuts) of Sanofi (incorporated by reference to Exhibit 1.1 to the Form 20-F).](http://www.sec.gov/Archives/edgar/data/1121404/000112140423000008/a2022-exhibit11.htm) |
| 4.2 | [Deposit Agreement (including the form of depositary receipt) between the Registrant and JPMorgan Chase Bank, N.A., as depositary (incorporated by reference to Exhibit A to the Registration Statement on Form F-6 (Registration No. 333-192032) relating to American Depositary Shares, filed with the Commission on October 31, 2013 and made effective on the same date, as amended by Post-Effective Amendment No. 1 thereto filed with the Commission on February 13, 2015 and further amended by Post-Effective Amendment No. 2 thereto filed with the Commission on August 4, 2020).](http://www.sec.gov/Archives/edgar/data/1121404/000119380513001990/e611494_ex99-a3.htm) |
| 4.3 | [Rules of the Sanofi-Aventis Group Savings Plan, of which the Action 2023 Shareholding Plan forms a part (incorporated by reference to Exhibit 4.3 to the Registration Statement on Form S-8 (Registration No. 333-129554) filed with the Commission on November 8, 2005).](http://www.sec.gov/Archives/edgar/data/1121404/000094787105001946/ex4-3_110305.txt) |
| 5.1\* | [Opinion of Alexandra Roger regarding the validity of the Registrant's ordinary shares being registered.](d447392dex51.htm) |
| 23.1\* | [Consent of PricewaterhouseCoopers Audit.](d447392dex231.htm) |
| 23.2\* | [Consent of Ernst & Young et Autres](d447392dex232.htm) |
| 23.3\* | [Consent of Alexandra Roger (included in Exhibit 5 above).](d447392dex51.htm) |
| 24\* | [Power of Attorney (included on the signature page).](d447392ds8.htm#sig) |
| 107\* | [Filing fee table.](d447392dexfilingfees.htm) |

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\* Filed herewith.

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**SIGNATURES** 

Pursuant to the requirements of the Securities Act, Sanofi certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Paris, France on March 30, 2023.

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| | |
|:---|:---|
| SANOFI | SANOFI |
| By: | /s/ Paul Hudson |
| Name: | Paul Hudson |
| Title: | Chief Executive Officer |

---

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**POWER OF ATTORNEY** 

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Paul Hudson, Jean-Baptiste Chasseloup de Chatillon and Roy Papatheodorou and each of them severally, his true and lawful attorney or attorneys, with power of substitution and resubstitution to sign in his name, place and stead in any and all such capacities, the registration statement on Form S-8 (the "Registration Statement") to be filed by Sanofi (the "Registrant") with the United States Securities and Exchange Commission (the "Commission") in connection with the Action 2023 Shareholding Plan, and any and all amendments thereto (including post-effective amendments) and any documents in connection therewith, and any registration statement filed by the Registrant pursuant to Rule 462(b) under the Securities Act of 1933, as amended, which relates to the Registration Statement, and to file any of the same with the Commission. Each of said attorneys shall have power to act with or without the others, and shall have full power and authority to do and perform, in the name and on behalf of each such officer and director of the Registrant who shall have executed this Power of Attorney, every act whatsoever which such attorneys, or any one of them, may deem necessary or desirable to be done in connection therewith as fully and to all intents and purposes as such officer or director of the Registrant might or could do in person.

Pursuant to the requirements of the Securities Act, this Registration Statement has been signed below by the following persons in the indicated capacities effective as of March 30, 2023.

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| | |
|:---|:---|
| **Signatures** | **Title** |
| /s/ Serge Weinberg<br> Serge Weinberg | Chairman of the Board of Directors |
| /s/ Paul Hudson<br> Paul Hudson | Chief Executive Officer and Director<br> (Principal Executive Officer) |
| /s/ Jean-Baptiste Chasseloup de Chatillon<br> Jean-Baptiste Chasseloup de Chatillon | Executive Vice President, Chief Financial<br> Officer (Principal Financial Officer) |
| /s/ Hervé Cardelli<br> Hervé Cardelli | Head of Consolidation and Statutory Reporting<br> (Principal Accounting Officer) |
| /s/ Patrick Kron<br> Patrick Kron | Director |
| /s/ Fabienne Lecorvaisier<br> Fabienne Lecorvaisier | Director |
| /s/ Rachel Duan<br> Rachel Duan | Director |
| /s/ Christophe Babule<br> Christophe Babule | Director |
| <br> Carole Ferrand | Director |
| /s/ Diane Souza<br> Diane Souza | Director |

---

------

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| | |
|:---|:---|
| /s/ Thomas Südhof<br> Thomas Südhof | Director |
| /s/ Emile Voest<br> Emile Voest | Director |
| /s/ Antoine Yver<br> Antoine Yver | Director |
| /s/ Gilles Schnepp<br> Gilles Schnepp | Director |
| /s/ Lise Kingo<br> Lise Kingo | Director |
| /s/ Barbara Lavernos<br> Barbara Lavernos | Director |
| /s/ Wolfgang Laux | Director |
| Wolfgang Laux | Director |
| /s/ Ceng-Yann Tran | Director |
| Ceng-Yann Tran | Director |
| /s/ Debora C. Pellicano<br> Debora C. Pellicano | Authorized Representative in the United States |

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## Exhibit 5.1

**Exhibit 5.1** 

March 30, 2023

Securities and Exchange Commission

450 Fifth Street, N.W., Washington, D.C. 20549

Ladies and Gentlemen:

I am Head of Securities Law and Capital Markets of Sanofi, a *société anonyme* organized under the laws of the Republic of France (the "Company"). In that capacity, I have acted as French counsel to the Company in connection with a registration statement on Form S-8 (the "Registration Statement") being filed with the United States Securities and Exchange Commission (the "SEC") for the purpose of registering under the United States Securities Act of 1933, as amended (the "Securities Act"), ordinary shares, nominal value €2.00 per share, of the Company ("Company Shares"), including Company Shares that may be represented by American depositary shares of the Company ("Company ADSs") (each Company ADS representing one-half of one Company Share), to be issued pursuant to the Action 2023 Shareholding Plan (the "Plan") to U.S. holders.

In furnishing this opinion, I, or lawyers under my supervision, have examined the Registration Statement, Resolution Number 23 of the General Meeting of the Shareholders of Sanofi held on April 30, 2021 and such other documents, corporate records, certificates of public officials and other agreements, instruments or opinions as I have deemed necessary or advisable for the purpose of rendering the opinion set forth below. In this examination, I have assumed the genuineness of all signatures, the authenticity of all documents submitted to me as original documents and the conformity to original documents of all documents submitted to me as copies. With respect to factual matters I have relied upon the accuracy of all facts and information set forth in the documents, corporate records, certificates and other agreements, instruments and opinions examined. On the basis of the foregoing, I am of the following opinion:

The Company Shares when issued pursuant to the Plan in accordance with the resolution of the general meeting of shareholders referred to above, will be validly issued, fully paid, and non-assessable.

The foregoing opinion is limited to matters involving the laws of the Republic of France. The foregoing opinion is also limited to the matters expressly stated in this letter, and no opinion shall be implied or inferred beyond the matters expressly stated. The foregoing opinion: (a) is rendered solely in connection with the registration, pursuant to the registration requirements of the Securities Act, of the offering, sale and delivery of the Company Shares to be issued in the United States pursuant to the purchase rights described in the Registration Statement; (b) may not be relied on for any other purpose; and (c) may not be reproduced, referred to or quoted in any offering materials, disclosure materials or similar printed matter.

---

| |
|:---|
| Very truly yours, |
| /s/ Alexandra Roger |
| Alexandra Roger |

---

## Exhibit 23.1

**Exhibit 23.1** 

**CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM** 

We hereby consent to the incorporation by reference in the Registration Statement on Form S-8 related to the Action 2023 Shareholding Plan of Sanofi, of our reports dated February 24, 2023 relating to the consolidated financial statements and the effectiveness of internal control over financial reporting, which appear in Sanofi's Annual Report on Form 20-F for the year ended December 31, 2022.

/s/ PricewaterhouseCoopers Audit

Neuilly-sur-Seine, France

March 30, 2023

## Exhibit 23.2

**Exhibit 23.2** 

**CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM** 

We consent to the incorporation by reference in the Registration Statement on Form S-8 pertaining to the Action 2023 Shareholding Plan of Sanofi, of our reports dated February 24, 2023, with respect to the consolidated financial statements of Sanofi and the effectiveness of internal control over financial reporting of Sanofi, included in its Annual Report (Form 20-F) for the year ended December 31, 2022, filed with the Securities and Exchange Commission.

/s/ Ernst & Young et Autres

Paris-La Défense, France

March 30, 2023

## Ex-Filing

**Exhibit 107** 

**Calculation of Filing Fee Tables** 

**Form S-8** 

(Form Type)

**SANOFI** 

(Exact Name of Registrant as Specified in its Charter)

**Table 1: Newly Registered Securities** 

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| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;&nbsp;Security Type | Security<br> Class Title | Fee<br> Calculation<br> Rule | Amount<br> Registered | Proposed<br> Maximum<br> Offering<br> Price Per<br> Unit | Maximum<br> Aggregate<br> Offering Price | Fee Rate | Amount of<br> Registration<br> Fee |
| &nbsp;&nbsp;&nbsp;Equity | Ordinary Shares, par value €2.00 per share (1) | Other (3) | 400000 (2) | $82.76 (3) | $33104000 | $110.20 per $1,000,000 | $3648.06 |
| &nbsp;&nbsp;&nbsp;Total Offering Amounts | &nbsp;&nbsp;&nbsp;Total Offering Amounts | &nbsp;&nbsp;&nbsp;Total Offering Amounts | &nbsp;&nbsp;&nbsp;Total Offering Amounts |  | $33104000 |  | $3648.06 |
| &nbsp;&nbsp;&nbsp;Total Fee Offsets | &nbsp;&nbsp;&nbsp;Total Fee Offsets | &nbsp;&nbsp;&nbsp;Total Fee Offsets | &nbsp;&nbsp;&nbsp;Total Fee Offsets |  |  |  | $2709.92 |
| &nbsp;&nbsp;&nbsp;Net Fee Due | &nbsp;&nbsp;&nbsp;Net Fee Due | &nbsp;&nbsp;&nbsp;Net Fee Due | &nbsp;&nbsp;&nbsp;Net Fee Due |  |  |  | $938.14 |

---

(1) American Depositary Receipts evidencing American Depositary Shares issuable upon request after expiration of the
five-year lock-up period on deposit of the Ordinary Shares, nominal value €2.00 per share ("Ordinary Shares"), have been registered pursuant to a separate Registration Statement on Form F-6 (Registration No. 333-192032).

(2) This Registration Statement covers up to 400,000 Ordinary Shares that may be sold to eligible employees
under the Action 2023 Shareholding Plan (the "Plan"). The amount being registered also includes an indeterminate number of shares of Ordinary Shares, which may be offered as a result of stock splits, stock dividends and anti-dilution
provisions and other terms, in each case in accordance with Rule 416, under the Securities Act of 1933, as amended (the "Securities Act").

(3) Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(c) and Rule 457(h)
under the Securities Act, based upon a 20% discount from the average of the high and low prices of the Registrant's Ordinary Shares on Euronext Paris on March 24, 2023 and converted at the noon buying rate of €1=$1.0762 on
March 24, 2023. The 20% discount represents the discount on the "Reference Price" offered to Participants pursuant to the Plan.

**Table 2: Fee Offset Claims and Sources** 

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| | | | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
|  | Registrant<br>or Filer<br>Name | Form<br>or<br>Filing<br>Type | File<br> Number (1) | Initial<br> Filing<br> Date | Filing<br> Date | Fee<br> Offset<br>Claimed | Security<br>Type<br>Associated<br>with Fee<br>Offset<br>Claimed | Security<br>Title<br>Associated<br>with Fee<br>Offset<br>Claimed | Unsold<br>Securities<br>Associated<br>with Fee | Unsold Aggregate<br>Offering<br> Amount Associated<br> with Fee Offset<br>Claimed | Fee Paid<br> with Fee<br> Offset Source |
| &nbsp;&nbsp;&nbsp;Rule 457(p) | &nbsp;&nbsp;&nbsp;Rule 457(p) | &nbsp;&nbsp;&nbsp;Rule 457(p) | &nbsp;&nbsp;&nbsp;Rule 457(p) | &nbsp;&nbsp;&nbsp;Rule 457(p) | &nbsp;&nbsp;&nbsp;Rule 457(p) | &nbsp;&nbsp;&nbsp;Rule 457(p) | &nbsp;&nbsp;&nbsp;Rule 457(p) | &nbsp;&nbsp;&nbsp;Rule 457(p) | &nbsp;&nbsp;&nbsp;Rule 457(p) | &nbsp;&nbsp;&nbsp;Rule 457(p) | &nbsp;&nbsp;&nbsp;Rule 457(p) |
| &nbsp;&nbsp;&nbsp;Fee Offset Claims(1) | SANOFI | S-8 | 333-218099 | 5/19/2017 |  | $2709.92 | Equity | Ordinary Shares, par value €2.00 per share | 296231 | $23381519.62 |  |
| &nbsp;&nbsp;&nbsp;Fee Offset Sources(1) | SANOFI | S-8 | 333-218099 |  | 5/19/2017 |  |  |  |  |  | $13721.99 |

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(1) Pursuant to Rule 457(p) under the Securities Act, the Registrant offsets the registration fee required in
connection with this Registration Statement by $2,709.92, which represents a portion of the dollar amount of the filing fee previously paid by the Registrant that corresponds to unsold Ordinary Shares registered pursuant to its (i) Registration
Statement on Form S-8 (Registration No. 333-218099) filed with the Securities and Exchange Commission (the "Commission") on May 19,
2017 and subsequently deregistered by a Post-Effective Amendment No. 1 to Form S-8 Registration Statement filed with the Commission on May 15, 2018; (ii) Registration Statement on Form S-8 (Registration No. 333-225522) filed with the Commission on June 8, 2018 and subsequently deregistered by a Post-Effective Amendment
No. 1 to Form S-8 Registration Statement filed with the Commission on May 13, 2020; (iii) Registration Statement on Form S-8 (Registration No. 333-238686) filed with the Commission on May 26, 2020 and subsequently deregistered by a Post-Effective Amendment No. 1 to Form S-8 Registration Statement filed with the Commission on April 23, 2021; (iv) Registration Statement on Form S-8 (Registration No. 333-256208) filed with the Commission on May 17, 2021 and subsequently deregistered by a Post-Effective
Amendment No. 1 to Form S-8 Registration Statement filed with the Commission on May 17, 2022 and (v) Registration Statement on Form S-8 (Registration No. 333-265050) filed with the Commission on May 18, 2022 and subsequently deregistered by a Post-Effective Amendment No. 1 to Form S-8 Registration Statement filed with the Commission on March 13, 2023. The Registrant has terminated or completed each offering that included the unsold Ordinary Shares offered under each of these Registration Statements on Form S-8 and has deregistered all such unsold Ordinary Shares by filing a Post-Effective Amendment to each such Registration Statement on Form S-8.