# EDGAR Filing Document

**Accession Number:** 0000320351
**File Stem:** 0000035402-26-002648
**Filing Date:** 2026-4
**Character Count:** 71913
**Document Hash:** 0e6309e03af88ef56c743b05941d1dfd
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000035402-26-002648.hdr.sgml**: 20260424

**ACCESSION NUMBER**: 0000035402-26-002648

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20260228

**FILED AS OF DATE**: 20260424

**DATE AS OF CHANGE**: 20260424

**PERIOD START**: 20260228

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** FIDELITY SELECT PORTFOLIOS
- **CENTRAL INDEX KEY:** 0000320351

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** MA
- **FISCAL YEAR END:** 0228

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-03114
- **FILM NUMBER:** 26895532

**BUSINESS ADDRESS:**
- **STREET 1:** 245 SUMMER STREET
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02210
- **BUSINESS PHONE:** 617-563-7000

**MAIL ADDRESS:**
- **STREET 1:** 245 SUMMER STREET
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02210

## Series and Classes Contracts Data

### Biotechnology Portfolio (Series ID: S000007486)

| Class ID   | Class Name              | Ticker Symbol   |
|:---|:---|:---|
| C000020460 | Biotechnology Portfolio | FBIOX           |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** Fidelity Select Portfolios

- **b. Investment Company Act file number:** 811-03114

- **c. CIK number of Registrant:** 0000320351

- **d. LEI of Registrant:** Z57125JG1LHEQKDYS630

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 245 Summer Street

  - **City:** Boston

  - **State:** MA

  - **Foreign country:** US

  - **Zip / Postal Code:** 02210

  - **Telephone number:** 1-800-FIDELITY

**Item A.2. Information about the Series.**

- **a. Name of Series:** Select Biotechnology Portfolio

- **b. EDGAR series identifier (if any):** S000007486

- **c. LEI of Series:** FQDPG178WXRZSXLIRG32

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2026-02-28

- **b. Date as of which information is reported:** 2026-02-28

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $5494637727.65

**Total Liabilities:** $142987381.14

**Net Assets:** $5351650346.51

**Cash Not Reported:** $98081.82

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000020460 | -0.81%               | 1.47%                | 2.43%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $36478804.25             | $-78885718.14                              |
| Month 2  | $42466806.95             | $31400153.69                               |
| Month 3  | $103570174.62            | $21212946.09                               |

### Schedule of Portfolio Investments

| Name                                      | Title                                                               | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| ORUKA THERAPEUTICS INC                    | ORUKA THERAPEUTICS INC                                              | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |    475783 | NS      | $16371693.03  | 0.31%             |  |  |  | No            |                  1 | On Loan: No      |
| ATYR PHARMA INC                           | ATYR PHARMA INC                                                     | CUSIP: 002120202<br>LEI: 529900ENQUXMC5EBKO36 | Long             | EC               | CORP              | US        |   1754594 | NS      | $1684059.32   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| ABBVIE INC                                | ABBVIE INC                                                          | CUSIP: 00287Y109<br>LEI: FR5LCKFTG8054YNNRU85 | Long             | EC               | CORP              | US        |   3049432 | NS      | $707712178.56 | 13.22%            |  |  |  | No            |                  1 | On Loan: No      |
| ALNYLAM PHARMACEUTICALS INC               | ALNYLAM PHARMACEUTICALS INC                                         | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |    496683 | NS      | $165355704.36 | 3.09%             |  |  |  | No            |                  1 | On Loan: No      |
| AMGEN INC                                 | AMGEN INC                                                           | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |   1149551 | NS      | $446209716.16 | 8.34%             |  |  |  | No            |                  1 | On Loan: No      |
| NEUROGENE INC                             | NEUROGENE INC                                                       | CUSIP: 64135M105<br>LEI: 529900A7VIY892SZVW73 | Long             | EC               | CORP              | US        |     51100 | NS      | $1200339.00   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| ARROWHEAD PHARMACEUTICALS INC             | ARROWHEAD PHARMACEUTICALS INC                                       | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |    409378 | NS      | $25901346.06  | 0.48%             |  |  |  | No            |                  1 | On Loan: No      |
| ASCENDIS PHARMA A/S                       | ASCENDIS PHARMA AS SPON ADR                                         | CUSIP: 04351P101<br>LEI: 549300B66JN3W3J8GH73 | Long             | EC               | CORP              | DK        |    558201 | NS      | $130339933.50 | 2.44%             |  |  |  | No            |                  1 | On Loan: No      |
| AXSOME THERAPEUTICS INC                   | AXSOME THERAPEUTICS INC                                             | CUSIP: 05464T104<br>LEI: 549300EXGR0XLRJEIB95 | Long             | EC               | CORP              | US        |     92303 | NS      | $15127538.67  | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| BIOCRYST PHARMACEUTICALS INC              | BIOCRYST PHARMACEUTICALS INC                                        | CUSIP: 09058V103<br>LEI: 549300Z0INP1Z5NP6J59 | Long             | EC               | CORP              | US        |     37881 | NS      | $331458.75    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| BIOGEN INC                                | BIOGEN INC                                                          | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |    299435 | NS      | $57437621.70  | 1.07%             |  |  |  | No            |                  1 | On Loan: No      |
| SOLENO THERAPEUTICS INC                   | SOLENO THERAPEUTICS INC                                             | CUSIP: 834203309<br>LEI: 5493003LCY77N7FXK844 | Long             | EC               | CORP              | US        |     87300 | NS      | $3410811.00   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| CAPRICOR THERAPEUTICS INC                 | CAPRICOR THERAPEUTICS INC                                           | CUSIP: 14070B309<br>LEI: 5493002ZI5PDLXV4DX14 | Long             | EC               | CORP              | US        |    314700 | NS      | $8789571.00   | 0.16%             |  |  |  | No            |                  1 | On Loan: —       |
| CORCEPT THERAPEUTICS INC                  | CORCEPT THERAPEUTICS INC                                            | CUSIP: 218352102<br>LEI: 529900EO9LUTFMZ7FF90 | Long             | EC               | CORP              | US        |    575646 | NS      | $20550562.20  | 0.38%             |  |  |  | No            |                  1 | On Loan: No      |
| CYTOKINETICS INC                          | CYTOKINETICS INC                                                    | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |    503175 | NS      | $31307548.50  | 0.59%             |  |  |  | No            |                  1 | On Loan: No      |
| CYTOMX THERAPEUTICS INC                   | CYTOMX THERAPEUTICS INC                                             | CUSIP: 23284F105<br>LEI: 5493004VW2FW0QLL3345 | Long             | EC               | CORP              | US        |   1222540 | NS      | $6565039.80   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| HANSA BIOPHARMA AB                        | HANSA BIOPHARMA AB                                                  | CUSIP: N/A<br>LEI: 549300LLEO25ZJJ3NT91       | Long             | EC               | CORP              | SE        |   1176800 | NS      | $4406025.96   | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| EXELIXIS INC                              | EXELIXIS INC                                                        | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |     40610 | NS      | $1789276.60   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Fidelity Revere Street Trust              | Fidelity Cash Central Fund                                          | CUSIP: 31635A105<br>LEI: 549300BDV45LJNXBZC55 | Long             | STIV             | RF                | US        |   4866721 | NS      | $4867694.57   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Fidelity Revere Street Trust              | Fidelity Securities Lending Cash Central Fund                       | CUSIP: 31635A303<br>LEI: 549300BDV45LJNXBZC55 | Long             | STIV             | RF                | US        | 136216589 | NS      | $136230210.30 | 2.55%             |  |  |  | No            |                  1 | On Loan: No      |
| GERON CORP                                | GERON CORP                                                          | CUSIP: 374163103<br>LEI: 549300T282D7Z2YESL90 | Long             | EC               | CORP              | US        |   6492512 | NS      | $10907420.16  | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| GILEAD SCIENCES INC                       | GILEAD SCIENCES INC                                                 | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |   3149952 | NS      | $469185350.40 | 8.77%             |  |  |  | No            |                  1 | On Loan: No      |
| CRESCENT BIOPHARMA INC                    | CRESCENT BIOPHARMA INC                                              | CUSIP: N/A<br>LEI: 549300TZ84FFU2J2J459       | Long             | EC               | CORP              | KY        |    113421 | NS      | $1371259.89   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| ZEALAND PHARMA A/S                        | ZEALAND PHARMA A/S                                                  | CUSIP: N/A<br>LEI: 549300ITBB1ULBL4CZ12       | Long             | EC               | CORP              | DK        |    589130 | NS      | $33892955.59  | 0.63%             |  |  |  | No            |                  1 | On Loan: No      |
| JAZZ PHARMACEUTICALS PLC                  | JAZZ PHARMA PLC                                                     | CUSIP: N/A<br>LEI: 635400GAUMJCLEZRRV50       | Long             | EC               | CORP              | IE        |     25600 | NS      | $4864512.00   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| INSMED INC                                | INSMED INC                                                          | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |    811101 | NS      | $121121712.33 | 2.26%             |  |  |  | No            |                  1 | On Loan: No      |
| IONIS PHARMACEUTICALS INC                 | IONIS PHARMACEUTICALS INC                                           | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |    476377 | NS      | $38657993.55  | 0.72%             |  |  |  | No            |                  1 | On Loan: No      |
| PERSPECTIVE THERAPEUTICS INC              | PERSPECTIVE THERAPEUTICS INC                                        | CUSIP: 46489V302<br>LEI: 5493005LRKM6BCABC605 | Long             | EC               | CORP              | US        |    258600 | NS      | $1396440.00   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| LEXICON PHARMACEUTICALS INC               | LEXICON PHARMACEUTICALS INC                                         | CUSIP: 528872302<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    515300 | NS      | $757491.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| MEDAVAIL HOLDINGS INC                     | MEDAVAIL HOLDINGS INC PIPE                                          | CUSIP: N/A<br>LEI: 549300ZNQGSJ2V3ZB668       | Long             | EC               | CORP              | US        |        55 | NS      | $0.01         | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| MANNKIND CORP                             | MANNKIND CORP                                                       | CUSIP: 56400P706<br>LEI: 213800GFBCNY1ZFST722 | Long             | EC               | CORP              | US        |   2185101 | NS      | $7167131.28   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| PROTHENA CORP PLC                         | PROTHENA CORP PLC                                                   | CUSIP: N/A<br>LEI: 5299009ZXQ8NIIJ8OL30       | Long             | EC               | CORP              | IE        |    643917 | NS      | $5582760.39   | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| NATERA INC                                | NATERA INC                                                          | CUSIP: 632307104<br>LEI: 529900CQ3OZ0A0VYVU59 | Long             | EC               | CORP              | US        |    331532 | NS      | $68971917.28  | 1.29%             |  |  |  | No            |                  1 | On Loan: No      |
| UNIQURE N.V.                              | UNIQURE N.V.                                                        | CUSIP: N/A<br>LEI: 724500RPCTZLFYJZ3S98       | Long             | EC               | CORP              | NL        |    650282 | NS      | $10163907.66  | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| OCULAR THERAPEUTIX INC                    | OCULAR THERAPEUTIX INC                                              | CUSIP: 67576A100<br>LEI: 529900ABAWFXOHSIHG03 | Long             | EC               | CORP              | US        |    784000 | NS      | $7008960.00   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC THERAPEUTICS INC                      | PTC THERAPEUTICS INC                                                | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |    134511 | NS      | $9172305.09   | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| BIO AB HOLDINGS LLC                       | BIO AB2 HOLDINGS LLC ADI                                            | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |   1954526 | NS      | $9186272.20   | 0.17%             |  |  |  | Yes           |                  3 | On Loan: No      |
| PALVELLA THERAPEUTICS INC                 | PALVELLA THERAPEUTICS INC                                           | CUSIP: 697947109<br>LEI: 254900AJDH8PAOOI5T33 | Long             | EC               | CORP              | US        |     16700 | NS      | $2254834.00   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| AFFERENT PHARMA                           | AFFERENT PHARMACEUTICALS INC SER C PC PP                            | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |   8274568 | NS      | $82.75        | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| REGENERON PHARMACEUTICALS INC             | REGENERON PHARMACEUTICALS INC                                       | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |    101316 | NS      | $79195677.72  | 1.48%             |  |  |  | No            |                  1 | On Loan: No      |
| NOVOCURE LTD                              | NOVOCURE LTD                                                        | CUSIP: N/A<br>LEI: 213800YPP55UMHWA4826       | Long             | EC               | CORP              | JE        |     11113 | NS      | $151914.71    | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| SENSORION SA                              | SENSORION SA                                                        | CUSIP: N/A<br>LEI: 969500P0W8XJ9CGZDP97       | Long             | EC               | CORP              | FR        |  18153474 | NS      | $7786402.57   | 0.15%             |  |  |  | No            |                  1 | On Loan: —       |
| TRAVERE THERAPEUTICS INC                  | TRAVERE THERAPEUTICS INC                                            | CUSIP: 89422G107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    720343 | NS      | $21459017.97  | 0.40%             |  |  |  | No            |                  1 | On Loan: No      |
| TWIST BIOSCIENCE CORP                     | TWIST BIOSCIENCE CORP                                               | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |    170825 | NS      | $8015109.00   | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| WAVE LIFE SCIENCES LTD                    | WAVE LIFE SCIENCES LTD                                              | CUSIP: N/A<br>LEI: 54930070006GPKFYZ813       | Long             | EC               | CORP              | SG        |    487140 | NS      | $6785860.20   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| INTELLIA THERAPEUTICS INC                 | INTELLIA THERAPEUTICS INC                                           | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |   1607833 | NS      | $22155938.74  | 0.41%             |  |  |  | No            |                  1 | On Loan: —       |
| VIRIDIAN THERAPEUTICS INC                 | VIRIDIAN THERAPEUTICS INC                                           | CUSIP: 92790C104<br>LEI: 549300C775BNYF550E70 | Long             | EC               | CORP              | US        |   1001204 | NS      | $29415373.52  | 0.55%             |  |  |  | No            |                  1 | On Loan: No      |
| MADRIGAL PHARMACEUTICALS INC              | MADRIGAL PHARMACEUTICALS INC                                        | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |     47495 | NS      | $20517840.00  | 0.38%             |  |  |  | No            |                  1 | On Loan: No      |
| TG THERAPEUTICS INC                       | TG THERAPEUTICS INC                                                 | CUSIP: 88322Q108<br>LEI: 529900X21UKABN9NJ529 | Long             | EC               | CORP              | US        |     66231 | NS      | $1992890.79   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| ULTRAGENYX PHARMACEUTICAL INC             | ULTRAGENYX PHARMA INC                                               | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |      3489 | NS      | $81607.71     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| UNITED THERAPEUTICS CORP DEL              | UNITED THERAPEUTICS CORP DEL                                        | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |     44593 | NS      | $22470412.70  | 0.42%             |  |  |  | No            |                  1 | On Loan: No      |
| UCB SA                                    | UCB SA                                                              | CUSIP: N/A<br>LEI: 2138008J191VLSGY5A09       | Long             | EC               | CORP              | BE        |    390274 | NS      | $116347579.17 | 2.17%             |  |  |  | No            |                  1 | On Loan: No      |
| VTV THERAPEUTICS INC                      | VTV THERAPEUTICS INC CL A                                           | CUSIP: 918385204<br>LEI: 549300WQE5EI9R35SE66 | Long             | EC               | CORP              | US        |    260391 | NS      | $9936520.56   | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| VERTEX PHARMACEUTICALS INC                | VERTEX PHARMACEUTICALS INC                                          | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |    112900 | NS      | $56092107.00  | 1.05%             |  |  |  | No            |                  1 | On Loan: No      |
| VIKING THERAPEUTICS INC                   | VIKING THERAPEUTICS INC                                             | CUSIP: 92686J106<br>LEI: 529900IVC72YPFA25M37 | Long             | EC               | CORP              | US        |    404257 | NS      | $13680056.88  | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| XENON PHARMACEUTICALS INC                 | XENON PHARMACEUTICALS INC                                           | CUSIP: 98420N105<br>LEI: 549300XV44Q9Z1MIPQ03 | Long             | EC               | CORP              | CA        |    297364 | NS      | $12855045.72  | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| BEONE MEDICINES LTD                       | BEONE MEDICINES LTD ADR                                             | CUSIP: 07725L102<br>LEI: 549300JFUK6FRD5MH739 | Long             | EC               | CORP              | CH        |     41698 | NS      | $13217849.02  | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| SPYRE THERAPEUTICS INC                    | SPYRE THERAPEUTICS INC                                              | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |    401953 | NS      | $17287998.53  | 0.32%             |  |  |  | No            |                  1 | On Loan: No      |
| CARTESIAN THERAPEUTICS INC                | CARTESIAN THERAPEUTICS INC                                          | CUSIP: 816212302<br>LEI: 529900NMN0LACZOL7C43 | Long             | EC               | CORP              | US        |    366554 | NS      | $2782144.86   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| PROTAGONIST THERAPEUTICS INC              | PROTAGONIST THERAPEUTICS INC                                        | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    506713 | NS      | $46658133.04  | 0.87%             |  |  |  | No            |                  1 | On Loan: No      |
| MODERNA INC                               | MODERNA INC                                                         | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |   1432529 | NS      | $76740578.53  | 1.43%             |  |  |  | No            |                  1 | On Loan: No      |
| ANAPTYSBIO INC                            | ANAPTYSBIO INC                                                      | CUSIP: 032724106<br>LEI: 529900HH4WQT03IG1A12 | Long             | EC               | CORP              | US        |     23300 | NS      | $1282665.00   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| FORTE BIOSCIENCES INC                     | FORTE BIOSCIENCES INC                                               | CUSIP: 34962G208<br>LEI: 529900Z84WFDHPS3JP76 | Long             | EC               | CORP              | US        |    310965 | NS      | $9397362.30   | 0.18%             |  |  |  | No            |                  1 | On Loan: —       |
| ARGENX SE                                 | ARGENX SE SPONSORED ADR                                             | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |    149344 | NS      | $114534900.48 | 2.14%             |  |  |  | No            |                  1 | On Loan: No      |
| IDORSIA LTD                               | IDORSIA LTD                                                         | CUSIP: N/A<br>LEI: 506700XOVZUB107S5720       | Long             | EC               | CORP              | CH        |   2174283 | NS      | $11071493.72  | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| ROIVANT SCIENCES LTD                      | ROIVANT SCIENCES LTD                                                | CUSIP: N/A<br>LEI: 549300DL466NY5J6U724       | Long             | EC               | CORP              | BM        |   1972719 | NS      | $57090487.86  | 1.07%             |  |  |  | No            |                  1 | On Loan: No      |
| KRYSTAL BIOTECH INC                       | KRYSTAL BIOTECH INC                                                 | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |   1806522 | NS      | $497949724.08 | 9.30%             |  |  |  | No            |                  1 | On Loan: —       |
| RHYTHM PHARMACEUTICALS INC                | RHYTHM PHARMACEUTICALS INC                                          | CUSIP: 76243J105<br>LEI: 529900JPNWXQ8DPLA551 | Long             | EC               | CORP              | US        |     99803 | NS      | $9254732.19   | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| APELLIS PHARMACEUTICALS INC               | APELLIS PHARMACEUTICALS INC                                         | CUSIP: 03753U106<br>LEI: 254900HS0ZFRXXSB9D42 | Long             | EC               | CORP              | US        |     23822 | NS      | $499309.12    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| X4 PHARMACEUTICALS INC                    | X4 PHARMACEUTICALS INC                                              | CUSIP: 98420X202<br>LEI: 549300R0UFVPXWP86U94 | Long             | EC               | CORP              | US        |   1685700 | NS      | $5798808.00   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| DENALI THERAPEUTICS INC                   | DENALI THERAPEUTICS INC                                             | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |    205263 | NS      | $4347470.34   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| SOLID BIOSCIENCES INC                     | SOLID BIOSCIENCES INC                                               | CUSIP: 83422E204<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1791160 | NS      | $11123103.60  | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| KINIKSA PHARMACEUTICALS INTERNATIONAL PLC | KINIKSA PHARMACEUTICALS INTERNATIONAL PLC                           | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | GB        |    267500 | NS      | $11901075.00  | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| BIOXCEL THERAPEUTICS INC                  | BIOXCEL THERAPEUTICS INC                                            | CUSIP: 09075P204<br>LEI: 549300Y25FYZ0E8LW260 | Long             | EC               | CORP              | US        |     90300 | NS      | $150801.00    | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| ARCUS BIOSCIENCES INC                     | ARCUS BIOSCIENCES INC                                               | CUSIP: 03969F109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    831100 | NS      | $16929507.00  | 0.32%             |  |  |  | No            |                  1 | On Loan: —       |
| COGENT BIOSCIENCES INC                    | COGENT BIOSCIENCES INC                                              | CUSIP: 19240Q201<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1691394 | NS      | $65710656.90  | 1.23%             |  |  |  | No            |                  1 | On Loan: No      |
| SCHOLAR ROCK HOLDING CORP                 | SCHOLAR ROCK HOLDING CORP                                           | CUSIP: 80706P103<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |   1650449 | NS      | $73065377.23  | 1.37%             |  |  |  | No            |                  1 | On Loan: —       |
| DIANTHUS THERAPEUTICS INC                 | DIANTHUS THERAPEUTICS INC                                           | CUSIP: 252828108<br>LEI: 549300Z3N6ODPCOFC890 | Long             | EC               | CORP              | US        |    432218 | NS      | $23854111.42  | 0.45%             |  |  |  | No            |                  1 | On Loan: —       |
| TECTONIC THERAPEUTIC INC                  | TECTONIC THERAPEUTIC INC                                            | CUSIP: 878972108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    442889 | NS      | $10385747.05  | 0.19%             |  |  |  | No            |                  1 | On Loan: —       |
| CRINETICS PHARMACEUTICALS INC             | CRINETICS PHARMACEUTICALS INC                                       | CUSIP: 22663K107<br>LEI: 549300Q1CNFXK5P31D28 | Long             | EC               | CORP              | US        |    926671 | NS      | $38086178.10  | 0.71%             |  |  |  | No            |                  1 | On Loan: No      |
| REPLIMUNE GROUP INC                       | REPLIMUNE GROUP INC                                                 | CUSIP: 76029N106<br>LEI: 549300AY704NEIRC4K64 | Long             | EC               | CORP              | US        |   1864545 | NS      | $14263769.25  | 0.27%             |  |  |  | No            |                  1 | On Loan: —       |
| ALLOGENE THERAPEUTICS INC                 | ALLOGENE THERAPEUTICS INC                                           | CUSIP: 019770106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1401115 | NS      | $3895099.70   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| ALECTOR INC                               | ALECTOR INC                                                         | CUSIP: 014442107<br>LEI: 549300Z8RQOIY1JMHC25 | Long             | EC               | CORP              | US        |   2221104 | NS      | $5397282.72   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| CYCLERION THERAPEUTICS INC                | CYCLERION THERAPEUTICS INC PP PIPE                                  | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |      4740 | NS      | $6399.00      | 0.00%             |  |  |  | Yes           |                  1 | On Loan: No      |
| TREVI THERAPEUTICS INC                    | TREVI THERAPEUTICS INC                                              | CUSIP: 89532M101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2288485 | NS      | $27278741.20  | 0.51%             |  |  |  | No            |                  1 | On Loan: —       |
| AXCELLA HEALTH INC                        | AXCELLA HEALTH INC                                                  | CUSIP: 05454B204<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     66454 | NS      | $0.66         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| IDEAYA BIOSCIENCES INC                    | IDEAYA BIOSCIENCES                                                  | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |    637957 | NS      | $20542215.40  | 0.38%             |  |  |  | No            |                  1 | On Loan: No      |
| REVOLUTION MEDICINES INC                  | REVOLUTION MEDICINES INC                                            | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |    438772 | NS      | $44763519.44  | 0.84%             |  |  |  | No            |                  1 | On Loan: No      |
| STOKE THERAPEUTICS INC                    | STOKE THERAPEUTICS INC                                              | CUSIP: 86150R107<br>LEI: 549300RD25SS2DIJHJ67 | Long             | EC               | CORP              | US        |    792594 | NS      | $28858347.54  | 0.54%             |  |  |  | No            |                  1 | On Loan: No      |
| BRIDGEBIO PHARMA INC                      | BRIDGEBIO PHARMA INC                                                | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |    707304 | NS      | $47021569.92  | 0.88%             |  |  |  | No            |                  1 | On Loan: No      |
| IMMUNOVANT INC                            | IMMUNOVANT INC                                                      | CUSIP: 45258J102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    250021 | NS      | $6933082.33   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| MIRUM PHARMACEUTICALS INC                 | MIRUM PHARMACEUTICALS INC                                           | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |     20400 | NS      | $1882716.00   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| BIONTECH SE                               | BIONTECH SE ADR                                                     | CUSIP: 09075V102<br>LEI: 894500UZJ5LG1F8J1U58 | Long             | EC               | CORP              | DE        |     85400 | NS      | $9413642.00   | 0.18%             |  |  |  | No            |                  1 | On Loan: —       |
| BEAM THERAPEUTICS INC                     | BEAM THERAPEUTICS INC                                               | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    244914 | NS      | $6970252.44   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| ENLIVEN THERAPEUTICS INC                  | ENLIVEN THERAPEUTICS INC                                            | CUSIP: 29337E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    363267 | NS      | $10785397.23  | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| KEROS THERAPEUTICS INC                    | KEROS THERAPEUTICS                                                  | CUSIP: 492327101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     24578 | NS      | $348761.82    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| LEGEND BIOTECH CORP                       | LEGEND BIOTECH CORP SPON ADR                                        | CUSIP: 52490G102<br>LEI: 254900EIUFZTW136H859 | Long             | EC               | CORP              | KY        |     32710 | NS      | $621490.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| VAXCYTE INC                               | VAXCYTE INC                                                         | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |    470455 | NS      | $29045891.70  | 0.54%             |  |  |  | No            |                  1 | On Loan: No      |
| VOR BIOPHARMA INC                         | VOR BIOPHARMA INC                                                   | CUSIP: 929033207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1536125 | NS      | $23717770.00  | 0.44%             |  |  |  | No            |                  1 | On Loan: —       |
| TAYSHA GENE THERAPIES INC                 | TAYSHA GENE THERAPIES INC                                           | CUSIP: 877619106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    940476 | NS      | $4260356.28   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| FOGHORN THERAPEUTICS INC                  | FOGHORN THERAPEUTICS INC                                            | CUSIP: 344174107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    654278 | NS      | $3716299.04   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| ANNEXON INC                               | ANNEXON INC                                                         | CUSIP: 03589W102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   4733596 | NS      | $26508137.60  | 0.50%             |  |  |  | No            |                  1 | On Loan: No      |
| NURIX THERAPEUTICS INC                    | NURIX THERAPEUTICS INC                                              | CUSIP: 67080M103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    396646 | NS      | $6334436.62   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| ARS PHARMACEUTICALS INC                   | ARS PHARMACEUTICALS INC                                             | CUSIP: 82835W108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    335156 | NS      | $3110247.68   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| HARMONY BIOSCIENCES HOLDINGS INC          | HARMONY BIOSCIENCES HOLDINGS INC                                    | CUSIP: 413197104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     17525 | NS      | $500163.50    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| DISC MEDICINE INC                         | DISC MEDICINE INC                                                   | CUSIP: 254604101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    532174 | NS      | $35453431.88  | 0.66%             |  |  |  | No            |                  1 | On Loan: No      |
| KYMERA THERAPEUTICS INC                   | KYMERA THERAPEUTICS INC                                             | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    462441 | NS      | $42243985.35  | 0.79%             |  |  |  | No            |                  1 | On Loan: No      |
| NUVATION BIO INC                          | NUVATION BIO INC                                                    | CUSIP: 67080N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2164933 | NS      | $12794754.03  | 0.24%             |  |  |  | No            |                  1 | On Loan: —       |
| TANGO THERAPEUTICS INC                    | TANGO THERAPEUTICS INC                                              | CUSIP: 87583X109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    586000 | NS      | $6528040.00   | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| DYNE THERAPEUTICS INC                     | DYNE THERAPEUTICS INC                                               | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1368144 | NS      | $21370409.28  | 0.40%             |  |  |  | No            |                  1 | On Loan: No      |
| SUMMIT THERAPEUTICS INC                   | SUMMIT THERAPEUTICS INC                                             | CUSIP: 86627T108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1089169 | NS      | $18069313.71  | 0.34%             |  |  |  | No            |                  1 | On Loan: —       |
| IMMUNOME INC                              | IMMUNOME INC                                                        | CUSIP: 45257U108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2131664 | NS      | $46598175.04  | 0.87%             |  |  |  | No            |                  1 | On Loan: —       |
| SHATTUCK LABS INC                         | SHATTUCK LABS INC                                                   | CUSIP: 82024L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    391662 | NS      | $1535315.04   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| VERA THERAPEUTICS INC                     | VERA THERAPEUTICS INC                                               | CUSIP: 92337R101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    109013 | NS      | $4446640.27   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| CHINOOK THERAPEUTICS INC                  | CHINOOK THERAPEUTICS INC CVR RT                                     | CUSIP: N/A<br>LEI: 549300X0O3003W5QYQ48       | Long             | EC               | CORP              | US        |    115821 | NS      | $1.16         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| PRAXIS PRECISION MEDICINES INC.           | PRAXIS PRECISION MEDICINES INC                                      | CUSIP: 74006W207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    390500 | NS      | $131500875.00 | 2.46%             |  |  |  | No            |                  1 | On Loan: No      |
| TARSUS PHARMACEUTICALS INC                | TARSUS PHARMACEUTICALS INC                                          | CUSIP: 87650L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4800 | NS      | $362496.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| MOONLAKE IMMUNOTHERAPEUTICS               | MOONLAKE IMMUNOTHERAPEUTICS                                         | CUSIP: 61559X104<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |    143558 | NS      | $2513700.58   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| GALECTO INC                               | GALECTO INC                                                         | CUSIP: 36322Q206<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    454559 | NS      | $13445855.22  | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| ATEA PHARMACEUTICALS INC                  | ATEA PHARMACEUTICALS INC                                            | CUSIP: 04683R106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    237534 | NS      | $1111659.12   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| INHIBIKASE THERAPEUTICS INC               | INHIBIKASE THERAPEUTICS INC                                         | CUSIP: 45719W205<br>LEI: 549300066CFEWOA17F12 | Long             | EC               | CORP              | US        |     56270 | NS      | $115353.50    | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| OLEMA PHARMACEUTICALS INC                 | OLEMA PHARMACEUTICALS INC                                           | CUSIP: 68062P106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    693100 | NS      | $16773020.00  | 0.31%             |  |  |  | No            |                  1 | On Loan: No      |
| NATIONAL RESILIENCE INC                   | NATIONAL RESILIENCE INC SER B PC PP                                 | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |    732064 | NS      | $2906294.08   | 0.05%             |  |  |  | Yes           |                  3 | On Loan: No      |
| SANA BIOTECHNOLOGY INC                    | SANA BIOTECHNOLOGY INC                                              | CUSIP: 799566104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1263152 | NS      | $5317869.92   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| TERNS PHARMACEUTICALS INC                 | TERNS PHARMACEUTICALS INC                                           | CUSIP: 880881107<br>LEI: 254900S1ZDQMF4MYP709 | Long             | EC               | CORP              | US        |   1079186 | NS      | $45455314.32  | 0.85%             |  |  |  | No            |                  1 | On Loan: No      |
| PHARVARIS BV                              | PHARVARIS BV                                                        | CUSIP: N/A<br>LEI: 9845003BE146D3B75D32       | Long             | EC               | CORP              | NL        |    147914 | NS      | $4199278.46   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| IMMUNOCORE HOLDINGS PLC                   | IMMUNOCORE HOLDINGS LTD ADR                                         | CUSIP: 45258D105<br>LEI: 213800IUE3DFS84BVN18 | Long             | EC               | CORP              | GB        |    321500 | NS      | $10384450.00  | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| ELEVATEBIO, LLC                           | ELEVATEBIO LLC SER C PC PP                                          | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |    216600 | NS      | $439698.00    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| LENZ THERAPEUTICS INC                     | LENZ THERAPEUTICS INC                                               | CUSIP: 52635N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     38058 | NS      | $513402.42    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| DESIGN THERAPEUTICS INC                   | DESIGN THERAPEUTICS INC                                             | CUSIP: 25056L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    616831 | NS      | $6439715.64   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| EDGEWISE THERAPEUTICS INC                 | EDGEWISE THERAPEUTICS INC                                           | CUSIP: 28036F105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    776925 | NS      | $23649597.00  | 0.44%             |  |  |  | No            |                  1 | On Loan: —       |
| BIOMEA FUSION INC                         | BIOMEA FUSION INC                                                   | CUSIP: 09077A106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    452663 | NS      | $620148.31    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| CENTESSA PHARMACEUTICALS PLC              | CENTESSA PHARMACEUTICALS LTD ADR                                    | CUSIP: 152309100<br>LEI: 213800GIDAARDSKOI827 | Long             | EC               | CORP              | GB        |   2187494 | NS      | $58756088.84  | 1.10%             |  |  |  | No            |                  1 | On Loan: No      |
| ERASCA INC                                | ERASCA INC                                                          | CUSIP: 29479A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     39880 | NS      | $544760.80    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| DAY ONE BIOPHARMACEUTICALS INC            | DAY ONE BIOPHARMACEUTICALS INC                                      | CUSIP: 23954D109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    108347 | NS      | $1148478.20   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| JADE BIOSCIENCES INC                      | JADE BIOSCIENCES INC                                                | CUSIP: 008064206<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    321707 | NS      | $4770914.81   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| JANUX THERAPEUTICS INC                    | JANUX THERAPEUTICS INC                                              | CUSIP: 47103J105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    206670 | NS      | $2812778.70   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| GH RESEARCH PLC                           | GH RESEARCH PLC                                                     | CUSIP: N/A<br>LEI: 875500HKJS7QQG6EWH62       | Long             | EC               | CORP              | IE        |     92500 | NS      | $1373625.00   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| CANDEL THERAPEUTICS INC                   | CANDEL THERAPEUTICS INC                                             | CUSIP: 137404109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   5911951 | NS      | $31037742.75  | 0.58%             |  |  |  | No            |                  1 | On Loan: —       |
| ABSCI CORP                                | ABSCI CORP                                                          | CUSIP: 00091E109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1540796 | NS      | $4221781.04   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| IMMUNEERING CORP                          | IMMUNEERING CORP                                                    | CUSIP: 45254E107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1290698 | NS      | $6440583.02   | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| NUVALENT INC                              | NUVALENT INC-A                                                      | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    273399 | NS      | $27873028.05  | 0.52%             |  |  |  | No            |                  1 | On Loan: No      |
| ENTRADA THERAPEUTICS INC                  | ENTRADA THERAPEUTICS INC                                            | CUSIP: 29384C108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     14169 | NS      | $169036.17    | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| ZURA BIO LTD                              | ZURA BIO LTD A                                                      | CUSIP: N/A<br>LEI: 549300LQXD6M2MIQFN24       | Long             | EC               | CORP              | KY        |    509657 | NS      | $3373929.34   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| GALDERMA GROUP AG                         | GALDERMA GROUP AG                                                   | CUSIP: N/A<br>LEI: 89450001OK6O8ELQ4584       | Long             | EC               | CORP              | CH        |    184660 | NS      | $34847192.70  | 0.65%             |  |  |  | No            |                  2 | On Loan: No      |
| AMYLYX PHARMACEUTICALS INC                | AMYLYX PHARMACEUTICALS INC                                          | CUSIP: 03237H101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1219575 | NS      | $18500952.75  | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| BIOHAVEN LTD                              | BIOHAVEN LTD                                                        | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | VG        |   1603096 | NS      | $18467665.92  | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| OPTINOSE INC                              | OPTINOSE INC WT 11/23/27                                            | CUSIP: 68404V118<br>LEI: 549300CPBME7Z3CYMN16 | Long             | EC               | CORP              | US        |     91712 | NS      | $0.92         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| NEWAMSTERDAM PHARMA COMPANY NV            | NEWAMSTERDAM PHARMA COMPANY NV                                      | CUSIP: N/A<br>LEI: 984500B6549TF6E14D36       | Long             | EC               | CORP              | NL        |    562500 | NS      | $19946250.00  | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| STRUCTURE THERAPEUTICS INC                | STRUCTURE THERAPEUTICS INC ADR                                      | CUSIP: 86366E106<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |    564438 | NS      | $35548305.24  | 0.66%             |  |  |  | No            |                  1 | On Loan: No      |
| MINERALYS THERAPEUTICS INC                | MINERALYS THERAPEUTICS INC                                          | CUSIP: 603170101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    421700 | NS      | $12338942.00  | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| APOGEE THERAPEUTICS INC                   | APOGEE THERAPEUTICS INC                                             | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    392757 | NS      | $27492990.00  | 0.51%             |  |  |  | No            |                  1 | On Loan: No      |
| RAPPORT THERAPEUTICS INC                  | RAPPORT THERAPEUTICS INC                                            | CUSIP: 75383L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    471773 | NS      | $13695570.19  | 0.26%             |  |  |  | No            |                  1 | On Loan: —       |
| GUBRA A/S                                 | GUBRA A/S                                                           | CUSIP: N/A<br>LEI: 254900T17RRFZONO6W53       | Long             | EC               | CORP              | DK        |    145554 | NS      | $8999875.70   | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| KORRO BIO INC                             | KORRO BIO INC PIPE                                                  | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |     32866 | NS      | $398664.58    | 0.01%             |  |  |  | Yes           |                  1 | On Loan: No      |
| ABIVAX SA                                 | ABIVAX SA                                                           | CUSIP: 00370M103<br>LEI: 969500D8TMNB184OJU95 | Long             | EC               | CORP              | FR        |    301600 | NS      | $36578048.00  | 0.68%             |  |  |  | No            |                  1 | On Loan: No      |
| ENGENE HOLDINGS INC                       | ENGENE HOLDINGS INC                                                 | CUSIP: 29286M105<br>LEI: N/A                  | Long             | EC               | CORP              | CA        |    232200 | NS      | $2347542.00   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| CARTESIAN THERAPEUTICS INC                | CARTESIAN THERAPEUTICS INC CVR RT                                   | CUSIP: 816212112<br>LEI: 529900NMN0LACZOL7C43 | Long             | EC               | CORP              | US        |   5385728 | NS      | $1561861.12   | 0.03%             |  |  |  | No            |                  3 | On Loan: No      |
| CG ONCOLOGY INC                           | CG ONCOLOGY INC                                                     | CUSIP: 156944100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     22628 | NS      | $1330526.40   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| ARRIVENT BIOPHARMA INC                    | ARRIVENT BIOPHARMA INC                                              | CUSIP: 04272N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1680003 | NS      | $38589668.91  | 0.72%             |  |  |  | No            |                  1 | On Loan: —       |
| BRIDGEBIO ONCOLOGY THERAPEUTIC            | BRIDGEBIO ONCOLOGY THERAPEUTIC                                      | CUSIP: 107924102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    240300 | NS      | $2410209.00   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| BIO AB HOLDINGS LLC                       | BIO AB2 HOLDINGS LLC ARC                                            | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |   1954526 | NS      | $20698430.34  | 0.39%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ORUKA THERAPEUTICS INC                    | ORUKA THERAPEUTICS INC PIPE                                         | CUSIP: N/A<br>LEI: 529900TG7O4ESUDMGI54       | Long             | EC               | CORP              | US        |     76300 | NS      | $2625483.00   | 0.05%             |  |  |  | Yes           |                  1 | On Loan: No      |
| EIKON THERAPEUTICS INC                    | EIKON THERAPEUTICS INC                                              | CUSIP: 282564103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    305088 | NS      | $4204112.64   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| ALUMIS INC                                | ALUMIS INC                                                          | CUSIP: 022307102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    561900 | NS      | $16682811.00  | 0.31%             |  |  |  | No            |                  1 | On Loan: No      |
| BICARA THERAPEUTICS INC                   | BICARA THERAPEUTICS INC                                             | CUSIP: 055477103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    944900 | NS      | $15855422.00  | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| CARDURION PHARMACEUTICALS INC             | CARDURION PHARMACEUTICALS INC SER B PC PP                           | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |   1020908 | NS      | $5431230.56   | 0.10%             |  |  |  | Yes           |                  3 | On Loan: No      |
| CANDID THERAPEUTICS                       | CANDID THERAPEUTICS INC SER B PC PP                                 | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |   1666667 | NS      | $2016667.07   | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ZENAS BIOPHARMA INC                       | ZENAS BIOPHARMA INC                                                 | CUSIP: 98937L105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    380400 | NS      | $10023540.00  | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| TRIVENI BIO INC                           | TRIVENI BIO INC SERIES B PC PP                                      | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |   7167431 | NS      | $8170871.34   | 0.15%             |  |  |  | Yes           |                  3 | On Loan: No      |
| CAMP4 THERAPEUTICS CORP                   | CAMP4 THERAPEUTICS CORP                                             | CUSIP: 13463J101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1326208 | NS      | $5954673.92   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| UPSTREAM BIO INC                          | UPSTREAM BIO INC                                                    | CUSIP: 91678A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    234657 | NS      | $1802165.76   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| CRESCENT BIOPHARMA INC                    | CRESCENT BIOPHARMA INC PIPE                                         | CUSIP: N/A<br>LEI: 549300TZ84FFU2J2J459       | Long             | EC               | CORP              | KY        |    149142 | NS      | $1803126.78   | 0.03%             |  |  |  | Yes           |                  1 | On Loan: No      |
| MAZE THERAPEUTICS INC                     | MAZE THERAPEUTICS INC                                               | CUSIP: 578784100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    311885 | NS      | $14218837.15  | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| ANTARES THERAPEUTICS INC                  | ANTARES THERAPEUTICS INC                                            | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |    325500 | NS      | $266910.00    | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| SCORPION THERAPEUTICS INC                 | SCORPION THERAPEUTICS INC CVR 03/05/2040 PP                         | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |   5166448 | NS      | $4236487.36   | 0.08%             |  |  |  | Yes           |                  3 | On Loan: No      |
| SCORPION THERAPEUTICS INC                 | SCORPION THERAPEUTICS INC INDEMNITY ESCROW LINE PP                  | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |   5166448 | NS      | $1756592.32   | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| SCORPION THERAPEUTICS INC                 | SCORPION THERAPEUTICS INC SHAREHOLDER REPRESENTATIVE ESCROW LINE PP | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |   5166448 | NS      | $51.66        | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| NEURONA THERAPEUTICS INC                  | NEURONA THERAPEUTICS INC SER F PC PERP PP                           | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |   1618100 | NS      | $3802535.00   | 0.07%             |  |  |  | Yes           |                  3 | On Loan: No      |
| BIOMEA FUSION INC                         | BIOMEA FUSION INC WT 12/20/2026                                     | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |     46134 | NS      | $1793.14      | 0.00%             |  |  |  | No            |                  2 | On Loan: No      |
| LB PHARMACEUTICALS INC                    | LB PHARMACEUTICALS INC                                              | CUSIP: 50180M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    221731 | NS      | $5323761.31   | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| CAMP4 THERAPEUTICS CORP                   | CAMP4 THERAPEUTICS CORP PIPE                                        | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |   1226606 | NS      | $5507460.94   | 0.10%             |  |  |  | Yes           |                  1 | On Loan: No      |
| ZENAS BIOPHARMA INC                       | ZENAS BIOPHARMA INC PIPE                                            | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |    263137 | NS      | $6933659.95   | 0.13%             |  |  |  | Yes           |                  1 | On Loan: No      |
| KARDIGAN INC                              | KARDIGAN, INC SER B PC PP                                           | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |     93611 | NS      | $2000467.07   | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| BLUE MARLIN THERAPEUTICS, INC.            | BLUE MARLIN THERAPEUTICS, INC.                                      | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |      1636 | NS      | $102250.00    | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| BIO TUB HOLDINGS LLC                      | BIO TUB HOLDINGS LLC PP                                             | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | DE        |      9200 | NS      | $3302307.31   | 0.06%             |  |  |  | Yes           |                  3 | On Loan: No      |
| AKTIS ONCOLOGY INC                        | AKTIS ONCOLOGY INC                                                  | CUSIP: 01021M104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    383955 | NS      | $7729014.15   | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| PARABILIS MEDICINES INC                   | PARABILIS MEDICINES INC SER F PC PP                                 | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |    491600 | NS      | $3033172.00   | 0.06%             |  |  |  | Yes           |                  3 | On Loan: No      |
| FOGHORN THERAPEUTICS INC                  | FOGHORN THERAPEUTICS INC WT 06/30/2027                              | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |    372579 | NS      | $31953.16     | 0.00%             |  |  |  | No            |                  2 | On Loan: No      |
| FOGHORN THERAPEUTICS INC                  | FOGHORN THERAPEUTICS INC WT 12/31/2030                              | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |    372579 | NS      | $151187.42    | 0.00%             |  |  |  | No            |                  2 | On Loan: No      |
| VERADERMICS INC                           | VERADERMICS INC                                                     | CUSIP: 922967104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     20800 | NS      | $953680.00    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2026-03-30

**Name of Applicant:** Stacie M. Smith

**Signature:** Stacie M. Smith

**Name of Signer:** Stacie M. Smith

**Title:** President and Treasurer