# EDGAR Filing Document

**Accession Number:** 0000873303
**File Stem:** 0001193125-25-174466
**Filing Date:** 2025-8
**Character Count:** 18723
**Document Hash:** b2b3e9856ba628541630e489cc9c1811
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-25-174466.hdr.sgml**: 20250806

**ACCESSION NUMBER**: 0001193125-25-174466

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 16

**FILED AS OF DATE**: 20250806

**DATE AS OF CHANGE**: 20250806

**EFFECTIVENESS DATE**: 20250806

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Sarepta Therapeutics, Inc.
- **CENTRAL INDEX KEY:** 0000873303
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 930797222
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-289296
- **FILM NUMBER:** 251189800

**BUSINESS ADDRESS:**
- **STREET 1:** 215 FIRST STREET
- **STREET 2:** SUITE 415
- **CITY:** CAMBRIDGE
- **STATE:** MA
- **ZIP:** 02142
- **BUSINESS PHONE:** 617-274-4000

**MAIL ADDRESS:**
- **STREET 1:** 215 FIRST STREET
- **STREET 2:** SUITE 415
- **CITY:** CAMBRIDGE
- **STATE:** MA
- **ZIP:** 02142

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Sarepta Therapuetics, Inc.
- **DATE OF NAME CHANGE:** 20120712

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** AVI BIOPHARMA INC
- **DATE OF NAME CHANGE:** 19980930

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ANTIVIRALS INC
- **DATE OF NAME CHANGE:** 19970123

**As filed with the Securities and Exchange Commission on August 6, 2025** 

**Registration No. 333-** 

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**Washington, D.C. 20549** 

**FORM S-8** 

**REGISTRATION STATEMENT** 

***UNDER***

***THE SECURITIES ACT OF 1933***

## Sarepta Therapeutics, Inc.
**(Exact name of registrant as specified in its charter)** 

---

| | |
|:---|:---|
| **Delaware** | **93-0797222** |
| **(State or other jurisdiction of**<br> **incorporation or organization)** | **(I.R.S. Employer**<br> **Identification No.)** |

---

**215 First Street, Suite 415** 

**Cambridge, Massachusetts 02142** 

**(Address of Principal Executive Offices) (Zip Code)** 

**Sarepta Therapeutics, Inc. 2018 Equity Incentive Plan, as amended** 

**Sarepta Therapeutics, Inc. Amended and Restated 2013 Employee Stock Purchase Plan (as amended and restated on** 

**June 27, 2016), as amended** 

**(Full title of the plan)** 

**Douglas S. Ingram** 

**Chief Executive Officer** 

**Sarepta Therapeutics, Inc.** 

**215 First Street, Suite 415** 

**Cambridge, Massachusetts 02142** 

**(Name and address of agent for service)** 

**(617) 274-4000** 

**(Telephone number, including area code, of agent for service)** 

***Copies to:***

**Paul M. Kinsella** 

**William J. Michener** 

**Ropes & Gray LLP** 

**Prudential Tower** 

**800 Boylston Street** 

**Boston, Massachusetts 02199** 

**(617) 951-7000** 

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☒ | Accelerated filer | ☐ |
| Non-accelerated filer | ☐ | Smaller reporting company | ☐ |
|  |  | Emerging growth company | ☐ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

------

**EXPLANATORY NOTE** 

This Registration Statement on Form S-8 (this "Registration Statement") is being filed to register an additional 4,300,000 shares of the Registrant's common stock, par value $0.0001 per share ("Common Stock"), for issuance under the 2018 Equity Incentive Plan, as amended, and an additional 300,000 shares of Common Stock for issuance under the Registrant's Amended and Restated 2013 Employee Stock Purchase Plan (as amended and restated on June 27, 2016), as amended. This Registration Statement is being filed in accordance with General Instruction E to Form S-8 regarding registration of additional securities of the same class, and, pursuant to such instruction, the contents of the Registration Statement on Form S-8 ([File No. 333-213002](http://www.sec.gov/Archives/edgar/data/873303/000119312516676792/d217466ds8.htm)) filed with the Securities and Exchange Commission on August 9, 2016, the contents of the Registration Statement on Form S-8 ([File No. 333-228719](http://www.sec.gov/Archives/edgar/data/873303/000119312518345018/d668756ds8.htm)) filed with the Securities and Exchange Commission on December 7, 2018, the contents of the Registration Statement on Form S-8 ([File No. 333-233715](http://www.sec.gov/Archives/edgar/data/873303/000119312519243057/d801842ds8.htm)) filed with the Securities and Exchange Commission on September 11, 2019, the contents of the Registration Statement on Form S-8 ([File No. 333-240996](http://www.sec.gov/Archives/edgar/data/873303/000156459020036860/srpt-s8.htm)) filed with the Securities and Exchange Commission on August 5, 2020, the contents of the Registration Statement on Form S-8 ([File No. 333-266461](http://www.sec.gov/Archives/edgar/data/873303/000119312522210023/d325482ds8.htm)) filed with the Securities and Exchange Commission on August 2, 2022, the contents of the Registration Form on S-8 ([File No. 333-273608](http://www.sec.gov/Archives/edgar/data/873303/000119312523201740/d515034ds8.htm)) filed with the Securities and Exchange Commission on August 2, 2023, the content of the Post-Effective Amendment to Registration Statement on Form S-8 ([File No. 333-240996](http://www.sec.gov/Archives/edgar/data/873303/000119312524080624/d793712ds8pos.htm)) filed with the Securities and Exchange Commission on March 28, 2024, and the content of the Post-Effective Amendment to Registration Statement on Form S-8 ([File No. 333-228719](http://www.sec.gov/Archives/edgar/data/873303/000119312524080633/d793712ds8pos.htm)) filed with the Securities and Exchange Commission on March 28, 2024 are each incorporated herein by reference.

**Item 8. Exhibits** 

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
|  | | **Incorporated by Reference to Filings<br>Indicated** | **Incorporated by Reference to Filings<br>Indicated** | **Incorporated by Reference to Filings<br>Indicated** | **Incorporated by Reference to Filings<br>Indicated** |
| **Exhibit <br>Number** | <br>**Description** | **Form** | **Exhibit** | **Filing<br>Date** | **Provided<br>Herewith** |
| &nbsp;&nbsp;&nbsp;&nbsp;4.1 | [Sarepta Therapeutics, Inc. 2018 Equity Incentive Plan](http://www.sec.gov/Archives/edgar/data/873303/000156459018020534/srpt-ex101_193.htm) | 10-Q | 10.1 | 8/8/18 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;4.2 | [Amendment No. 1 to the Sarepta Therapeutics, Inc. 2018 Equity Incentive Plan](http://www.sec.gov/Archives/edgar/data/873303/000156459020028562/srpt-ex101_25.htm) | 8-K | 10.1 | 6/8/20 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;4.3 | [Amendment No. 2 to the Sarepta Therapeutics, Inc. 2018 Equity Incentive Plan](http://www.sec.gov/Archives/edgar/data/873303/000095017022011164/srpt-ex10_1.htm) | 8-K | 10.1 | 6/3/2022 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;4.4 | [Amendment No. 3 to the Sarepta Therapeutics, Inc. 2018 Equity Incentive Plan](http://www.sec.gov/Archives/edgar/data/873303/000095017023027276/srpt-ex10_1.htm) | 8-K | 10.1 | 6/9/2023 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;4.5 | [Amendment No. 4 to the Sarepta Therapeutics, Inc. 2018 Equity Incentive Plan](http://www.sec.gov/Archives/edgar/data/873303/000095017025083131/srpt-ex10_1.htm) | 8-K | 10.1 | 6/6/2025 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;4.6 | [Amended and Restated 2013 Employee Stock Purchase Plan (as amended and restated on June 27, 2016)](http://www.sec.gov/Archives/edgar/data/873303/000119312516640523/d395691dex102.htm) | 8-K | 10.2 | 7/1/16 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;4.7 | [Amendment No. 1 to the Sarepta Therapeutics, Inc. Amended and Restated 2013 Employee Stock Purchase Plan (as amended and restated on June 27, 2016)](http://www.sec.gov/Archives/edgar/data/873303/000156459019030035/srpt-ex104_240.htm) | 10-Q | 10.4 | 8/7/19 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;4.8 | [Amendment No. 2 to the Sarepta Therapeutics, Inc. Amended and Restated 2013 Employee Stock Purchase Plan (as amended and restated on June 27, 2016)](http://www.sec.gov/Archives/edgar/data/873303/000095017023027276/srpt-ex10_2.htm) | 8-K | 10.2 | 6/9/2023 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;4.9 | [Amendment No. 3 to the Sarepta Therapeutics, Inc. Amended and Restated 2013 Employee Stock Purchase Plan (as amended and restated on June 27, 2016)](http://www.sec.gov/Archives/edgar/data/873303/000095017025083131/srpt-ex10_2.htm) | 8-K | 10.2 | 6/6/2025 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;5.1 | [Opinion of Ropes & Gray LLP](d29892dex51.htm) |  |  |  | X |
| 23.1 | [Consent of Ropes & Gray LLP (included in Exhibit 5.1)](d29892dex51.htm) |  |  |  | X |

---

------

---

| | | |
|:---|:---|:---|
| 23.2 | [Consent of KPMG LLP, independent registered public accounting firm](d29892dex232.htm) | X |
| 24.1 | [Power of Attorney (included in the signature page to this Registration Statement)](d29892ds8.htm#sig) | X |
| 107 | [Filing Fees](d29892dexfilingfees.htm) | X |

---

------

**SIGNATURES** 

Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Cambridge, Commonwealth of Massachusetts, on August 6, 2025.

---

| | |
|:---|:---|
|  **Sarepta Therapeutics, Inc.** | **Sarepta Therapeutics, Inc.** |
| By: | /s/ Douglas S. Ingram |
|  | Douglas S. Ingram |
|  | Chief Executive Officer |

---

**SIGNATURES AND POWERS OF ATTORNEY** 

Each person whose signature appears below hereby constitutes and appoints Douglas S. Ingram, Ian M. Estepan and Cristin L. Rothfuss, and each of them singly, his or her true and lawful attorney-in-fact and agent with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement on Form S-8 of Sarepta Therapeutics, Inc., and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents full power and authority to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or their substitutes, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed below by the following persons in the capacities indicated below on the dates indicated:

---

| | | |
|:---|:---|:---|
| **Signature** | **Title** | **Date** |
| /s/ Douglas S. Ingram<br> Douglas S. Ingram | Chief Executive Officer, Director<br> (Principal Executive Officer) | August 6, 2025 |
| /s/ Ryan H. Wong<br> Ryan H. Wong | Executive Vice President, Chief Financial Officer<br> (Principal Financial and Accounting Officer) | August 6, 2025 |
| /s/ M. Kathleen Behrens, Ph.D.<br> M. Kathleen Behrens, Ph.D. | Chairwoman of the Board | August 6, 2025 |
| /s/ Richard J. Barry<br> Richard J. Barry | Director | August 6, 2025 |
| /s/ Kathryn Boor, Ph.D.<br> Kathryn Boor, Ph.D. | Director | August 6, 2025 |
| /s/ Deirdre Connelly<br> Deirdre Connelly | Director | August 6, 2025 |
| /s/ Michael Chambers<br> Michael Chambers | Director | August 6, 2025 |

---

------

---

| | | |
|:---|:---|:---|
| /s/ Stephen L. Mayo, Ph.D.<br> Stephen L. Mayo, Ph.D. | Director | August 6, 2025 |
| /s/ Claude Nicaise, M.D.<br> Claude Nicaise, M.D. | Director | August 6, 2025 |
| /s/ Hans Wigzell, M.D., Ph.D.<br> Hans Wigzell, M.D., Ph.D. | Director | August 6, 2025 |

---

## Exhibit 5.1

**Exhibit 5.1** 

---

| | |
|:---|:---|
| ![LOGO](g29892g0805104728858.jpg) | ROPES & GRAY LLP<br> PRUDENTIAL TOWER<br> 800 BOYLSTON STREET<br> BOSTON, MA 02199-3600<br> WWW.ROPESGRAY.COM |

---

August 6, 2025

Sarepta Therapeutics, Inc.

215 First Street, Suite 415

Cambridge, Massachusetts 02142

Ladies and Gentlemen:

This opinion letter is furnished to you in connection with the registration statement on Form S-8 (the "<u>Registration Statement</u>"), filed by Sarepta Therapeutics, Inc., a Delaware corporation (the "<u>Company</u>"), on the date hereof, with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the "<u>Securities Act</u>"), for the registration of 4,600,000 shares of Common Stock, $0.0001 par value, of the Company (the "<u>Shares</u>"). The Shares are issuable under the Company's 2018 Equity Incentive Plan, as amended (the "2018 <u>Plan</u>") and the Company's Amended and Restated 2013 Employee Stock Purchase Plan, as amended and restated on June 27, 2016 (the "<u>ESPP</u>" and together with the 2018 Plan, the "<u>Plans</u>").

We are familiar with the actions taken by the Company in connection with the adoption of the Plans. We have examined such certificates, documents and records and have made such investigation of fact and such examination of law as we have deemed appropriate in order to enable us to render the opinions set forth herein. In conducting such investigation, we have relied, without independent verification, upon certificates of officers of the Company, public officials and other appropriate persons.

The opinions expressed below are limited to the Delaware General Corporation Law.

Based upon and subject to the foregoing, we are of the opinion that the Shares have been duly authorized and, when the Shares have been issued and sold in accordance with the terms of the Plans, the Shares will be validly issued, fully paid and nonassessable.

We hereby consent to the filing of this opinion letter as an exhibit to the Registration Statement. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations thereunder.

------

Sarepta Therapeutics, Inc. - 2 -

---

| |
|:---|
|  Very truly yours, |
|  /s/ Ropes & Gray LLP<br> Ropes & Gray LLP |

---

## Exhibit 23.2

**Exhibit 23.2**![LOGO](g29892g01r91.jpg)

KPMG LLP

Two Financial Center

60 South Street

Boston, MA 02111

**Consent of Independent Registered Public Accounting Firm** 

We consent to the use of our report dated February 28, 2025, with respect to the consolidated financial statements of Sarepta Therapeutics, Inc., and the effectiveness of internal control over financial reporting, incorporated herein by reference.

/s/ KPMG LLP

Boston, Massachusetts

August 6, 2025

<br>KPMG LLP, a Delaware limited liability partnership and a member firm of

the KPMG global organization of independent member firms affiliated with

KPMG International Limited, a private English company limited by guarantee.

## Ex-Filing

?xml version='1.0' encoding='ASCII'? EX-FILING FEES

---

| |
|:---|
| **Calculation of Filing Fee Tables**  |
| &nbsp;&nbsp;&nbsp;&nbsp;**S-8**  |
| &nbsp;&nbsp;&nbsp;&nbsp;**Sarepta Therapeutics, Inc.**  |

---

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | **Security Type**  | **Security Class Title**  | **Fee Calculation Rule**  | **Amount Registered**  | **Proposed Maximum Offering Price Per Unit**  | **Maximum Aggregate Offering Price**  | **Fee Rate**  | **Amount of Registration Fee**  |
| 1 | Equity | Sarepta Therapeutics, Inc. 2018 Equity Incentive Plan, as amended-Common Stock, par value $0.0001 per share | Other | 4300000 | $16.01 | $68843000.00 | 0.0001531 | $10539.87 |
| 2 | Equity | Sarepta Therapeutics, Inc. Amended and Restated 2013 Employee Stock Purchase Plan, as amended-Common Stock, par value $0.0001 per share | Other | 300000 | $16.01 | $4803000.00 | 0.0001531 | $735.34 |
| Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: |  | $73646000.00  |  | $11275.21  |
| Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  |  |  |  | $0.00  |
| Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  |  |  |  | $11275.21  |

---

 **Offering Note** <br>

<sup>1</sup> (1) Pursuant to Rule 416(a) under the Securities Act of 1933, as amended, this Registration Statement on Form S-8 (the "Registration Statement") shall also cover shares of the Registrant's common stock that become issuable under the Plans to prevent dilution as a result of any stock dividend, stock split, recapitalization or similar transaction. (2) Represents 4,300,000 shares of common stock reserved for future issuance under the Sarepta Therapeutics, Inc. 2018 Equity Incentive Plan, as amended. (3) Estimated solely for the purpose of determining the registration fee pursuant to Rule 457(c) and 457(h) under the Securities Act, the "proposed maximum offering price per share" is calculated based on the average of the high and low prices for the Registrant's common stock as reported on the Nasdaq Global Select Market on August 1, 2025.

<sup>2</sup> (1) Pursuant to Rule 416(a) under the Securities Act of 1933, as amended, this Registration Statement on Form S-8 (the "Registration Statement") shall also cover shares of the Registrant's common stock that become issuable under the Plans to prevent dilution as a result of any stock dividend, stock split, recapitalization or similar transaction. (3) Estimated solely for the purpose of determining the registration fee pursuant to Rule 457(c) and 457(h) under the Securities Act, the "proposed maximum offering price per share" is calculated based on the average of the high and low prices for the Registrant's common stock as reported on the Nasdaq Global Select Market on August 1, 2025. (4) Represents 300,000 shares of common stock reserved for future issuance under the Sarepta Therapeutics, Inc. Amended and Restated 2013 Employee Stock Purchase Plan (as amended and restated on June 27, 2016), as amended.

---

| | |
|:---|:---|
| | |
| **Rule 457(p)** | **Rule 457(p)** |
| Fee Offset Claims | N/A |
| Fee Offset Sources | N/A |

---