# EDGAR Filing Document

**Accession Number:** 0001971532
**File Stem:** 0001641172-25-015522
**Filing Date:** 2025-6
**Character Count:** 6394
**Document Hash:** 4e9f56d551a60bd3716d4a7bb752aa58
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001641172-25-015522.hdr.sgml**: 20250618

**ACCESSION NUMBER**: 0001641172-25-015522

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 12

**CONFORMED PERIOD OF REPORT**: 20250618

**ITEM INFORMATION**: Other Events

**FILED AS OF DATE**: 20250618

**DATE AS OF CHANGE**: 20250618

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Telomir Pharmaceuticals, Inc.
- **CENTRAL INDEX KEY:** 0001971532
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 872606031
- **STATE OF INCORPORATION:** FL
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-41952
- **FILM NUMBER:** 251055294

**BUSINESS ADDRESS:**
- **STREET 1:** 100 SE 2ND ST
- **STREET 2:** SUITE 2000 #1009
- **CITY:** MIAMI
- **STATE:** FL
- **ZIP:** 33131
- **BUSINESS PHONE:** 786-396-6723

**MAIL ADDRESS:**
- **STREET 1:** 100 SE 2ND ST
- **STREET 2:** SUITE 2000 #1009
- **CITY:** MIAMI
- **STATE:** FL
- **ZIP:** 33131

?xml version='1.0' encoding='ASCII'?

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**WASHINGTON, D.C. 20549**

**FORM 8-K**

**CURRENT REPORT**

**Pursuant to Section 13 or 15(d) of the**

**Securities Exchange Act of 1934**

**Date of Report (Date of earliest event reported): June 18, 2025**

**TELOMIR PHARMACEUTICALS, INC.**

**(Exact Name of Registrant as Specified in its Charter)**

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| | | |
|:---|:---|:---|
| **Florida** | **001-41952** | **87-2606031** |
| **(State or Other Jurisdiction<br> of Incorporation)** | **(Commission** <br> **File Number)** | **(IRS Employer<br> Identification No.)** |

---

**100 SE 2nd St, Suite 2000, #1009**

**Miami, Florida**

**(Address of Principal Executive Offices)**

**Registrant's telephone number, including area code: (786) 396-6723**

**Not Applicable**

**(Former Name or Former Address, if Changed Since Last Report)**

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

<u>Title of each class</u> <u>Trading Symbol</u> <u>Name of each exchange on which registered</u> <br> Common Stock, no par value TELO The Nasdaq Stock Market LLC

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

**Item 8.01 Other Events**

On June 18, 2025, Telomir Pharmaceuticals, Inc. (Nasdaq: TELO), a preclinical-stage biotechnology company focused on reversing biological aging and age-related diseases, announced positive new preclinical data demonstrating the cellular protective activity of its lead candidate, Telomir-1, in human progeria cell lines.

Progeria, or Hutchinson-Gilford Progeria Syndrome (HGPS), is an ultra-rare pediatric disorder caused by a mutation in the *LMNA* gene, leading to the production of progerin—a toxic protein that causes rapid biological aging in children. There are fewer than 30 known patients in the United States, with an average life expectancy of 13 to 15 years. The only approved treatment, Zokinvy® (lonafarnib), extends lifespan by approximately 4.3 years but does not reverse the underlying disease pathology or halt cardiovascular decline, the leading cause of death.

The Company evaluated Telomir-1 in cells taken directly from a child with HGPS. These cells were obtained from The Progeria Research Foundation (<u>www.progeriaresearch.org</u>). The study, conducted by SmartAssays, focused on three critical hallmarks of cellular aging and disease progression in Progeria: loss of viability, oxidative stress, and mitochondrial dysfunction.

**Key findings include:**

● **Telomir-1 significantly increased cell viability**, both under basal conditions and even in the presence of toxic levels of iron and copper.

● **Reactive oxygen species (ROS), elevated in Progeria cells**, were normalized by Telomir-1, both under basal conditions and even under oxidative stress conditions.

● **Calcium overload—a marker of mitochondrial damage—was reversed**, restoring mitochondrial function and energy balance.

Telomir-1 is designed to regulate intracellular metal ions, reduce oxidative stress, restore mitochondrial function, extend telomere length, reverse muscle loss, and reset age-associated DNA methylation patterns—biological pathways that play central roles in Progeria and other degenerative conditions.

The results build on prior studies in *zebrafish and C. elegans* models of Werner syndrome (adult progeria), where Telomir-1 extended lifespan, restored telomere length, reversed muscle degeneration, and reset epigenetic aging markers.

Telomir Pharmaceuticals is finalizing IND-enabling studies and intends to engage with the U.S. Food and Drug Administration (FDA) to explore regulatory pathways, including the potential for orphan drug designation. The Company is evaluating multiple rare disease indications for initial clinical development.

**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

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| | | |
|:---|:---|:---|
|  | **TELOMIR PHARMACEUTICALS, INC.** | **TELOMIR PHARMACEUTICALS, INC.** |
| Dated: June 18, 2025 | By: | */s/ Erez Aminov* |
|  | Name: | Erez Aminov&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; |
|  | Title: | Chief Executive Officer |

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