# EDGAR Filing Document

**Accession Number:** 0000320351
**File Stem:** 0001752724-23-014701
**Filing Date:** 2023-1
**Character Count:** 108112
**Document Hash:** 303c0f0d6c7d5a1d96305b704cefbc92
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001752724-23-014701.hdr.sgml**: 20230126

**ACCESSION NUMBER**: 0001752724-23-014701

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20221130

**FILED AS OF DATE**: 20230126

**DATE AS OF CHANGE**: 20230126

**PERIOD START**: 20230228

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** FIDELITY SELECT PORTFOLIOS
- **CENTRAL INDEX KEY:** 0000320351
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** MA
- **FISCAL YEAR END:** 0228

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-03114
- **FILM NUMBER:** 23556556

**BUSINESS ADDRESS:**
- **STREET 1:** 245 SUMMER STREET
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02210
- **BUSINESS PHONE:** 617-563-7000

**MAIL ADDRESS:**
- **STREET 1:** 245 SUMMER STREET
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02210

## Series and Classes Contracts Data

### Biotechnology Portfolio (Series ID: S000007486)

| Class ID   | Class Name              | Ticker Symbol   |
|:---|:---|:---|
| C000020460 | Biotechnology Portfolio | FBIOX           |

## Nport-Ex

**Quarterly Holdings Report**

**for**

**Fidelity**<sup>®</sup> **Select Portfolios**<sup>®</sup>

**Biotechnology Portfolio**

**November 30, 2022**

BIO-NPRT3-0123

1.810668.118 ---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;**Common Stocks - 98.2%** | &nbsp;&nbsp;**Common Stocks - 98.2%** | &nbsp;&nbsp;**Common Stocks - 98.2%** |
|  | Shares | Value ($)<br>|
| Biotechnology - 91.7%  |  |  |
| Biotechnology - 91.7% |  |  |
| 2seventy bio, Inc. (a) | 103752 | 1625794 |
| 4D Molecular Therapeutics, Inc. (a) | 24264 | 586461 |
| AbbVie, Inc.  | 3617903 | 583133604 |
| Absci Corp. (a)(b) | 997800 | 2494500 |
| ADC Therapeutics SA (a)(b) | 635838 | 2327167 |
| Adicet Bio, Inc. (a)(b) | 713361 | 12968903 |
| Adverum Biotechnologies, Inc. (a)(b)(c) | 8332581 | 5581996 |
| Aerovate Therapeutics, Inc. (a)(b) | 77051 | 1451641 |
| Aldeyra Therapeutics, Inc. (a)(b) | 961337 | 5383487 |
| Alector, Inc. (a) | 914318 | 7762560 |
| Alkermes PLC (a) | 687536 | 17037142 |
| Allena Pharmaceuticals, Inc. (a) | 93683 | 1096 |
| Allogene Therapeutics, Inc. (a)(b) | 1556685 | 15348914 |
| Allovir, Inc. (a)(b) | 852383 | 6401396 |
| Alnylam Pharmaceuticals, Inc. (a) | 1100139 | 242679662 |
| ALX Oncology Holdings, Inc. (a) | 1280549 | 14214094 |
| Ambrx Biopharma, Inc. ADR (a) | 1361508 | 667071 |
| Amgen, Inc.  | 429703 | 123066939 |
| Amicus Therapeutics, Inc. (a)(b) | 2261101 | 27359322 |
| AnaptysBio, Inc. (a)(b) | 273328 | 7552053 |
| Apellis Pharmaceuticals, Inc. (a) | 1431684 | 71483982 |
| Applied Therapeutics, Inc. (a)(b)(c) | 2639536 | 2956280 |
| Arcellx, Inc.  | 605400 | 12071676 |
| Arcturus Therapeutics Holdings, Inc. (a)(b) | 875824 | 16150195 |
| Arcus Biosciences, Inc. (a)(b) | 3193396 | 112311737 |
| Arcutis Biotherapeutics, Inc. (a) | 894174 | 15406618 |
| Argenx SE ADR (a) | 407247 | 162072089 |
| Arrowhead Pharmaceuticals, Inc. (a) | 1923532 | 61937730 |
| Ars Pharmaceuticals, Inc. (a)(b) | 1675577 | 10422089 |
| Ascendis Pharma A/S sponsored ADR (a)(b) | 659409 | 81146872 |
| aTyr Pharma, Inc. (a)(b) | 1146952 | 2477416 |
| Aura Biosciences, Inc. (a) | 519959 | 7425015 |
| Avidity Biosciences, Inc. (a)(b) | 476750 | 5549370 |
| Axcella Health, Inc. (a)(b) | 1661354 | 1396202 |
| Beam Therapeutics, Inc. (a)(b) | 528692 | 24420283 |
| BELLUS Health, Inc. (a) | 2069064 | 20421662 |
| Bicycle Therapeutics PLC ADR (a)(b) | 377647 | 10936657 |
| BioCryst Pharmaceuticals, Inc. (a)(b) | 3649042 | 48751201 |
| Biogen, Inc. (a) | 703036 | 214545496 |
| Biohaven Ltd. (a)(b) | 2823752 | 44671757 |
| BioInvent International AB (a) | 786506 | 2700796 |
| BioMarin Pharmaceutical, Inc. (a) | 347448 | 35085299 |
| Biomea Fusion, Inc. (a)(b) | 407129 | 2927258 |
| BioNTech SE ADR  | 185928 | 31053695 |
| BioXcel Therapeutics, Inc. (a)(b) | 351727 | 5828116 |
| Blueprint Medicines Corp. (a) | 1461508 | 69845467 |
| BridgeBio Pharma, Inc. (a)(b) | 613842 | 5751700 |
| Candel Therapeutics, Inc. (a)(b) | 737596 | 1290793 |
| Celldex Therapeutics, Inc. (a) | 819700 | 30402673 |
| Centessa Pharmaceuticals PLC ADR (a)(b) | 1230909 | 4923636 |
| Century Therapeutics, Inc. (a)(b) | 834618 | 8763489 |
| Cerevel Therapeutics Holdings (a)(b) | 1044180 | 30239453 |
| Chinook Therapeutics, Inc. (a) | 303781 | 6880640 |
| Chinook Therapeutics, Inc. rights (a)(d) | 115821 | 1 |
| Codiak Biosciences, Inc. (a)(b) | 448539 | 309537 |
| Codiak Biosciences, Inc. warrants 9/15/27 (a) | 46000 | 6217 |
| Cogent Biosciences, Inc. (a) | 1139767 | 14338269 |
| Compass Therapeutics, Inc.  | 2232400 | 9175164 |
| Crinetics Pharmaceuticals, Inc. (a) | 1179587 | 21079220 |
| CRISPR Therapeutics AG (a)(b) | 305022 | 16712155 |
| Cyclerion Therapeutics, Inc. (a) | 837285 | 795421 |
| Cyclerion Therapeutics, Inc. (a)(e) | 94809 | 90069 |
| Cyteir Therapeutics, Inc. (a) | 451123 | 649617 |
| Cytokinetics, Inc. (a)(b) | 2154571 | 91569268 |
| Day One Biopharmaceuticals, Inc. (a) | 845671 | 17953595 |
| Denali Therapeutics, Inc. (a) | 417851 | 13333625 |
| Design Therapeutics, Inc. (a)(b) | 806620 | 11292680 |
| Dyne Therapeutics, Inc. (a) | 310813 | 3636512 |
| Enanta Pharmaceuticals, Inc. (a) | 263946 | 11558195 |
| Entrada Therapeutics, Inc. (a)(b) | 503853 | 7542679 |
| EQRx, Inc. (a) | 507567 | 1908452 |
| EQRx, Inc.: |  |  |
|  rights (a)(d) | 116649  | 381442  |
|  rights (a)(d) | 49993  | 132981  |
| Erasca, Inc. (a) | 635623 | 4798954 |
| Evelo Biosciences, Inc. (a)(b) | 1098999 | 2296908 |
| Exelixis, Inc. (a) | 2072034 | 35390341 |
| Fate Therapeutics, Inc. (a)(b) | 608787 | 12674945 |
| Foghorn Therapeutics, Inc. (a)(b) | 252746 | 1706036 |
| Fusion Pharmaceuticals, Inc. (a) | 1142702 | 2593934 |
| G1 Therapeutics, Inc. (a) | 276904 | 1650348 |
| Gemini Therapeutics, Inc. (a)(b) | 1555907 | 2676160 |
| Generation Bio Co. (a) | 137100 | 730743 |
| Geron Corp. (a) | 174306 | 404390 |
| Geron Corp. warrants 12/31/25 (a) | 2100000 | 1396702 |
| Gilead Sciences, Inc.  | 437804 | 38452325 |
| Gossamer Bio, Inc. (a)(b) | 1687174 | 14442209 |
| Graphite Bio, Inc. (a) | 1058457 | 3736353 |
| Gritstone Bio, Inc. (a)(b) | 431580 | 1268845 |
| Halozyme Therapeutics, Inc. (a) | 531800 | 30450868 |
| Hookipa Pharma, Inc. (a) | 1480200 | 1569012 |
| Horizon Therapeutics PLC (a) | 325247 | 32619022 |
| Icosavax, Inc. (a) | 490857 | 1639462 |
| Ideaya Biosciences, Inc. (a)(b) | 715157 | 12787007 |
| Idorsia Ltd. (a)(b) | 1092661 | 16200657 |
| IGM Biosciences, Inc. (a)(b) | 591539 | 13019773 |
| Immuneering Corp. (a)(b) | 188677 | 1224514 |
| Immunocore Holdings PLC ADR (a)(b) | 267318 | 16790244 |
| ImmunoGen, Inc. (a) | 922023 | 4785299 |
| Incyte Corp. (a) | 427600 | 34066892 |
| Inhibrx, Inc. (a)(b) | 254309 | 7624184 |
| Insmed, Inc. (a) | 647392 | 11970278 |
| Instil Bio, Inc. (a) | 1445074 | 1921948 |
| Intellia Therapeutics, Inc. (a) | 885001 | 45542151 |
| Ionis Pharmaceuticals, Inc. (a) | 1084277 | 44227659 |
| iTeos Therapeutics, Inc. (a) | 238000 | 4795700 |
| Iveric Bio, Inc. (a) | 555584 | 13122894 |
| Janux Therapeutics, Inc. (a)(b) | 714722 | 9748808 |
| Karuna Therapeutics, Inc. (a) | 393512 | 92597309 |
| Keros Therapeutics, Inc. (a) | 378977 | 18888214 |
| Kiniksa Pharmaceuticals Ltd. (a)(b) | 177166 | 2981704 |
| Kinnate Biopharma, Inc. (a)(b) | 1808291 | 14321665 |
| Kronos Bio, Inc. (a)(b) | 617758 | 1173740 |
| Krystal Biotech, Inc. (a)(b)(c) | 2105960 | 163717330 |
| Kymera Therapeutics, Inc. (a)(b) | 1072813 | 31090121 |
| Legend Biotech Corp. ADR (a) | 912716 | 47014001 |
| Madrigal Pharmaceuticals, Inc. (a)(b) | 153140 | 10736645 |
| MannKind Corp. (a)(b) | 6449301 | 30182729 |
| Merus BV (a)(b) | 458686 | 7040830 |
| Mirati Therapeutics, Inc. (a) | 662148 | 60507084 |
| Moderna, Inc. (a) | 888986 | 156381527 |
| Monte Rosa Therapeutics, Inc. (a)(b) | 1257805 | 10666186 |
| Morphic Holding, Inc. (a)(b) | 805337 | 22162874 |
| Morphosys AG sponsored ADR (a) | 217028 | 894155 |
| Natera, Inc. (a) | 356133 | 14644189 |
| Nkarta, Inc. (a)(b) | 244766 | 2075616 |
| Nurix Therapeutics, Inc. (a)(b) | 1056746 | 13093083 |
| Nuvalent, Inc. Class A (a) | 218574 | 7186713 |
| Omega Therapeutics, Inc. (a)(b) | 915541 | 6408787 |
| Oragenics, Inc. (a) | 155806 | 30663 |
| ORIC Pharmaceuticals, Inc. (a) | 98139 | 352319 |
| PepGen, Inc.  | 440591 | 6591241 |
| Poseida Therapeutics, Inc. (a) | 570083 | 2599578 |
| Prelude Therapeutics, Inc. (a) | 359156 | 2395571 |
| Prometheus Biosciences, Inc. (a) | 342555 | 14082436 |
| Protagonist Therapeutics, Inc. (a) | 124027 | 981054 |
| Prothena Corp. PLC (a) | 761589 | 47606928 |
| PTC Therapeutics, Inc. (a) | 2267944 | 94096997 |
| Rallybio Corp. (a)(b) | 1550692 | 8931986 |
| RAPT Therapeutics, Inc. (a) | 750682 | 13272058 |
| Recursion Pharmaceuticals, Inc. (a)(b) | 89200 | 838480 |
| Regeneron Pharmaceuticals, Inc. (a) | 271706 | 204241400 |
| Regulus Therapeutics, Inc. (a)(b)(c) | 2195000 | 3753450 |
| Relay Therapeutics, Inc. (a)(b) | 770589 | 14317544 |
| Repare Therapeutics, Inc. (a)(b) | 174960 | 2804609 |
| Replimune Group, Inc. (a) | 910817 | 18644424 |
| Revolution Medicines, Inc. (a)(b) | 418772 | 9878831 |
| Rhythm Pharmaceuticals, Inc. (a)(b) | 826303 | 22120131 |
| Rocket Pharmaceuticals, Inc. (a)(b) | 223736 | 4224136 |
| Roivant Sciences Ltd. (a)(b) | 5957525 | 31932334 |
| Roivant Sciences Ltd. (a)(e) | 2500000 | 13400000 |
| Sage Therapeutics, Inc. (a) | 699553 | 28709655 |
| Sarepta Therapeutics, Inc. (a) | 552604 | 67865297 |
| Scholar Rock Holding Corp. (a)(b) | 1693925 | 13161797 |
| Scholar Rock Holding Corp. warrants 12/31/25 (a)(e) | 17850 | 55193 |
| Seagen, Inc. (a) | 357732 | 43425087 |
| Selecta Biosciences, Inc. (a) | 395568 | 518194 |
| Sensorion SA (a)(b) | 2243198 | 992007 |
| Seres Therapeutics, Inc. (a)(b) | 854347 | 5553256 |
| Shattuck Labs, Inc. (a) | 110936 | 251825 |
| SpringWorks Therapeutics, Inc. (a)(b) | 463711 | 11212532 |
| SpringWorks Therapeutics, Inc. (e) | 54800 | 1192558 |
| Stoke Therapeutics, Inc. (a) | 203036 | 1530891 |
| Sutro Biopharma, Inc. (a) | 540100 | 4045349 |
| Tango Therapeutics, Inc. (a) | 1463188 | 10988542 |
| Taysha Gene Therapies, Inc. (a) | 811647 | 1793740 |
| Tenaya Therapeutics, Inc. (a) | 1263918 | 3349383 |
| TG Therapeutics, Inc. (a)(b) | 1976220 | 17430260 |
| Travere Therapeutics, Inc. (a) | 300428 | 6047616 |
| Twist Bioscience Corp. (a)(b) | 681332 | 18634430 |
| Tyra Biosciences, Inc. (a) | 342201 | 2398829 |
| Ultragenyx Pharmaceutical, Inc. (a) | 978351 | 35514141 |
| uniQure B.V. (a) | 255608 | 6763388 |
| United Therapeutics Corp. (a) | 442409 | 123825855 |
| Vaxcyte, Inc. (a) | 1355250 | 62422815 |
| Vera Therapeutics, Inc. (a) | 779768 | 13022126 |
| Vertex Pharmaceuticals, Inc. (a) | 709810 | 224583884 |
| Verve Therapeutics, Inc. (a)(b) | 249393 | 5793399 |
| Vigil Neuroscience, Inc. (b) | 86610 | 1082625 |
| Vor Biopharma, Inc. (a)(b) | 696659 | 3204631 |
| X4 Pharmaceuticals, Inc. warrants 4/12/24 (a) | 450000 | 41 |
| Xencor, Inc. (a) | 169343 | 5032874 |
| Xenon Pharmaceuticals, Inc. (a) | 1004333 | 37039801 |
| Zealand Pharma A/S (a)(b) | 375400 | 10746405 |
| Zentalis Pharmaceuticals, Inc. (a) | 638433 | 14122138 |
|  |  | 4903853044 |
| Food & Staples Retailing - 0.0%  |  |  |
| Drug Retail - 0.0% |  |  |
| MedAvail Holdings, Inc. (a) | 2777 | 1164 |
| Health Care Equipment & Supplies - 0.0%  |  |  |
| Health Care Equipment - 0.0% |  |  |
| Alpha Tau Medical Ltd. Class A (a)(b) | 362046 | 1444564 |
| Novocure Ltd. (a) | 11113 | 853923 |
|  |  | 2298487 |
| Health Care Providers & Services - 0.2%  |  |  |
| Health Care Services - 0.2% |  |  |
| 23andMe Holding Co. Class A (a)(b) | 2046974 | 6243271 |
| Guardant Health, Inc. (a) | 82500 | 4318050 |
|  |  | 10561321 |
| Health Care Technology - 0.1%  |  |  |
| Health Care Technology - 0.1% |  |  |
| Schrodinger, Inc. (a) | 199427 | 3589686 |
| Life Sciences Tools & Services - 0.1%  |  |  |
| Life Sciences Tools & Services - 0.1% |  |  |
| Olink Holding AB ADR (a) | 57100 | 1360693 |
| Seer, Inc. (a) | 304058 | 1964215 |
|  |  | 3324908 |
| Pharmaceuticals - 6.1%  |  |  |
| Pharmaceuticals - 6.1% |  |  |
| Adimab LLC (a)(d)(e)(f) | 1954526 | 78747853 |
| Afferent Pharmaceuticals, Inc. rights 12/31/24 (a)(d) | 8274568 | 8605551 |
| Aradigm Corp. (a)(d) | 11945 | 549 |
| Aradigm Corp. (a)(d) | 148009 | 6808 |
| Arvinas Holding Co. LLC (a) | 382343 | 15691357 |
| Atea Pharmaceuticals, Inc. (a) | 66800 | 313292 |
| Axsome Therapeutics, Inc. (a)(b) | 242373 | 17521144 |
| CinCor Pharma, Inc. (b) | 81593 | 962797 |
| Corcept Therapeutics, Inc. (a) | 164400 | 4156032 |
| DICE Therapeutics, Inc. (a)(b) | 451946 | 15732240 |
| Edgewise Therapeutics, Inc. (a) | 1704107 | 15251758 |
| Fulcrum Therapeutics, Inc. (a)(b) | 1631789 | 11177755 |
| GH Research PLC (a)(b) | 893124 | 9770777 |
| Harmony Biosciences Holdings, Inc. (a) | 135325 | 8088375 |
| Ikena Oncology, Inc. (a) | 416547 | 928900 |
| Intra-Cellular Therapies, Inc. (a) | 559989 | 30362604 |
| Longboard Pharmaceuticals, Inc. (a) | 371100 | 1992807 |
| Nuvation Bio, Inc. (a)(b) | 727400 | 1389334 |
| OptiNose, Inc. (a)(b) | 794031 | 1405435 |
| OptiNose, Inc. warrants (a) | 91712 | 59516 |
| Pharvaris BV (a) | 353507 | 728224 |
| Pliant Therapeutics, Inc. (a)(b) | 372222 | 6841440 |
| Rain Therapeutics, Inc. (a) | 206669 | 1595485 |
| Reata Pharmaceuticals, Inc. (a)(b) | 381628 | 15104836 |
| Royalty Pharma PLC  | 285820 | 12567505 |
| Terns Pharmaceuticals, Inc. (a) | 810600 | 6298362 |
| Theseus Pharmaceuticals, Inc. (a)(b) | 1857891 | 12243502 |
| Trevi Therapeutics, Inc. (a) | 1299855 | 2443727 |
| UCB SA  | 121277 | 9789060 |
| Ventyx Biosciences, Inc. (a)(b) | 716630 | 20775104 |
| Verona Pharma PLC ADR (a) | 290000 | 3741000 |
| Verrica Pharmaceuticals, Inc. (a)(b) | 1597876 | 5193097 |
| WAVE Life Sciences (a)(b) | 1696733 | 7194148 |
|  |  | 326680374 |
| <br> **TOTAL COMMON STOCKS**<br> (Cost $3,973,997,054) |  | <br> **5250308984** |

---

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;**Convertible Preferred Stocks - 1.4%** | &nbsp;&nbsp;**Convertible Preferred Stocks - 1.4%** | &nbsp;&nbsp;**Convertible Preferred Stocks - 1.4%** |
|  | Shares | Value ($)<br>|
| Biotechnology - 1.2%  |  |  |
| Biotechnology - 1.2% |  |  |
| ElevateBio LLC Series C (a)(d)(e) | 216600 | 990512 |
| Korro Bio, Inc.: |  |  |
|  Series B1 (d)(e) | 957854  | 1829501  |
|  Series B2 (d)(e) | 899280  | 1717625  |
| National Resilience, Inc. Series B (a)(d)(e) | 732064 | 44458247 |
| SalioGen Therapeutics, Inc. Series B (d)(e) | 94461 | 7043957 |
| ValenzaBio, Inc. Series A (a)(d)(e) | 1685311 | 9993894 |
|  |  | 66033736 |
| Health Care Providers & Services - 0.1%  |  |  |
| Health Care Services - 0.1% |  |  |
| Scorpion Therapeutics, Inc. Series B (a)(d)(e) | 3099905 | 3874881 |
| Pharmaceuticals - 0.1%  |  |  |
| Pharmaceuticals - 0.1% |  |  |
| Afferent Pharmaceuticals, Inc. Series C (a)(d)(e) | 8274568 | 83 |
| Aristea Therapeutics, Inc. Series B (a)(d)(e) | 836400 | 6431916 |
|  |  | 6431999 |
| <br> **TOTAL CONVERTIBLE PREFERRED STOCKS**<br> (Cost $53,020,299) |  | <br> **76340616** |

---

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;**Money Market Funds - 8.5%** | &nbsp;&nbsp;**Money Market Funds - 8.5%** | &nbsp;&nbsp;**Money Market Funds - 8.5%** |
|  | Shares | Value ($)<br>|
| Fidelity Cash Central Fund 3.86% (g) | 9911593 | 9913575 |
| Fidelity Securities Lending Cash Central Fund 3.86% (g)(h) | 447029121 | 447073824 |
| <br> **TOTAL MONEY MARKET FUNDS**<br> (Cost $456,953,758) |  | **456987399** |

---

---

| | |
|:---|:---|
| <br> **TOTAL INVESTMENT IN SECURITIES - 108.1%**<br> (Cost $4,483,971,111)<br>| <br>**5783636999** |
| **NET OTHER ASSETS (LIABILITIES) - (8.1)%**  | **(435779983)** |
| **NET ASSETS - 100.0%** | **5347857016** |

---

**Legend**

(a) Non-income producing

(b) Security or a portion of the security is on loan at period end.

(c) Affiliated company

(d) Level 3 security

(e) Restricted securities (including private placements) - Investment in securities not registered under the Securities Act of 1933 (excluding 144A issues). At the end of the period, the value of restricted securities (excluding 144A issues) amounted to $169,826,289 or 3.2% of net assets.

(f) Investment is owned by a wholly-owned subsidiary (Subsidiary) that is treated as a corporation for U.S. tax purposes.

(g) Affiliated fund that is generally available only to investment companies and other accounts managed by Fidelity Investments. The rate quoted is the annualized seven-day yield of the fund at period end. A complete unaudited listing of the fund's holdings as of its most recent quarter end is available upon request. In addition, each Fidelity Central Fund's financial statements are available on the SEC's website or upon request.

(h) Investment made with cash collateral received from securities on loan.

---

| | | |
|:---|:---|:---|
| Additional information on each restricted holding is as follows: | Additional information on each restricted holding is as follows: | Additional information on each restricted holding is as follows: |
| Security | Acquisition Date | Acquisition Cost ($)<br>|
| Adimab LLC | 9/17/14 - 6/05/15 | 31218977 |
| Afferent Pharmaceuticals, Inc. Series C | 7/01/15 | 0 |
| Aristea Therapeutics, Inc. Series B | 10/06/20 | 4611659 |
| Cyclerion Therapeutics, Inc. | 4/02/19 | 1404026 |
| ElevateBio LLC Series C | 3/09/21 | 908637 |
| Korro Bio, Inc. Series B1 | 12/17/21 | 2499999 |
| Korro Bio, Inc. Series B2 | 12/17/21 | 2499998 |
| National Resilience, Inc. Series B | 12/01/20 | 9999994 |
| Roivant Sciences Ltd. | 5/01/21 | 25000000 |
| SalioGen Therapeutics, Inc. Series B | 12/10/21 | 10000019 |
| Scholar Rock Holding Corp. warrants 12/31/25 | 6/17/22 | 0 |
| Scorpion Therapeutics, Inc. Series B | 1/08/21 | 7500000 |
| SpringWorks Therapeutics, Inc. | 9/07/22 | 1425348 |
| ValenzaBio, Inc. Series A | 3/25/21 | 14999993 |

---

**Affiliated Central Funds**

Fiscal year to date information regarding the Fund's investments in Fidelity Central Funds, including the ownership percentage, is presented below.

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| Affiliate  | Value,<br> beginning<br> of period ($) | Purchases ($) | Sales<br> Proceeds ($) | Dividend<br> Income ($) | Realized<br> Gain (loss) ($) | Change in<br> Unrealized<br> appreciation<br> (depreciation) ($) | Value,<br> end<br> of period ($) | % ownership,<br> end<br> of period |
| Fidelity Cash Central Fund 3.86% | 42446755 | 853872649 | 886405829 | 410199 | 3258 | (3258) | 9913575 | 0.0% |
| Fidelity Securities Lending Cash Central Fund 3.86% | 492109261 | 1822937237 | 1867972674 | 6001517 | - | - | 447073824 | 1.4% |
| Total | 534556016 | 2676809886 | 2754378503 | 6411716 | 3258 | (3258) | 456987399 |  |

---

Amounts in the income column in the above table include any capital gain distributions from underlying funds.

Amount for Fidelity Securities Lending Cash Central Fund represents the income earned on investing cash collateral, less rebates paid to borrowers and any lending agent fees associated with the loan, plus any premium payments received for lending certain types of securities.

**Other Affiliated Issuers**

An affiliated company is a company in which the Fund has ownership of at least 5% of the voting securities. Fiscal year to date transactions with companies which are or were affiliates are as follows:

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| Affiliate  | Value,<br> beginning<br> of period ($) | Purchases ($) | Sales<br> Proceeds ($) | Dividend<br> Income ($) | Realized<br> Gain (loss) ($) | Change in<br> Unrealized<br> appreciation<br> (depreciation) ($) | Value,<br> end<br> of period ($) |
| Adverum Biotechnologies, Inc. | - | 14311389 | 1586381 | - | (1487269) | (5655743) | 5581996 |
| Applied Therapeutics, Inc. | 1070923 | 2575660 | 1176547 | - | (14439872) | 14926116 | 2956280 |
| Candel Therapeutics, Inc. | 8593545 | - | 6141156 | - | (4644572) | 3482976 | - |
| Krystal Biotech, Inc. | 126760516 | 6531325 | - | - | - | 30425489 | 163717330 |
| Regulus Therapeutics, Inc. | - | 4631450 | - | - | - | (878000) | 3753450 |
| Total | 136424984 | 28049824 | 8904084 | - | (20571713) | 42300838 | 176009056 |

---

**Investment Valuation**

Investments are valued as of 4:00 p.m. Eastern time on the last calendar day of the period. Securities transactions are accounted for as of trade date. The Board of Trustees (the Board) has designated the Fund's investment adviser as the valuation designee responsible for the fair valuation function and performing fair value determinations as needed. The investment adviser has established a Fair Value Committee (the Committee) to carry out the day-to-day fair valuation responsibilities and has adopted policies and procedures to govern the fair valuation process and the activities of the Committee. In accordance with these fair valuation policies and procedures, which have been approved by the Board, the Fund attempts to obtain prices from one or more third party pricing services or brokers to value its investments. When current market prices, quotations or currency exchange rates are not readily available or reliable, investments will be fair valued in good faith by the Committee, in accordance with the policies and procedures. Factors used in determining fair value vary by investment type and may include market or investment specific events, transaction data, estimated cash flows, and market observations of comparable investments. The frequency that the fair valuation procedures are used cannot be predicted and they may be utilized to a significant extent. The Committee manages the Fund's fair valuation practices and maintains the fair valuation policies and procedures. The Fund's investment adviser reports to the Board information regarding the fair valuation process and related material matters.

The inputs to valuation techniques used to value investments are categorized into a disclosure hierarchy consisting of three levels as shown below:

Level 1 - Unadjusted quoted prices in active markets for identical investments

Level 2 - other significant observable inputs (including quoted prices for similar investments, interest rates, prepayment speeds, etc.)

Level 3 - unobservable inputs (including the Fund's own assumptions based on the best information available)

Valuation techniques used to value investments by major category are as follows:

Equity securities, including restricted securities, for which market quotations are readily available, are valued at the last reported sale price or official closing price as reported by a third party pricing service on the primary market or exchange on which they are traded and are categorized as Level 1 in the hierarchy. In the event there were no sales during the day or closing prices are not available, securities are valued at the last quoted bid price or may be valued using the last available price and are generally categorized as Level 2 in the hierarchy. For any foreign equity securities, when market or security specific events arise, comparisons to the valuation of American Depositary Receipts (ADRs), futures contracts, Exchange-Traded Funds (ETFs) and certain indexes as well as quoted prices for similar securities may be used and would be categorized as Level 2 in the hierarchy. For equity securities, including restricted securities, where observable inputs are limited, assumptions about market activity and risk are used and these securities may be categorized as Level 3 in the hierarchy.

Securities, including private placements or other restricted securities, for which observable inputs are not available are valued using alternate valuation approaches, including the market approach, the income approach and cost approach, and are categorized as Level 3 in the hierarchy. The market approach considers factors including the price of recent investments in the same or a similar security or financial metrics of comparable securities. The income approach considers factors including expected future cash flows, security specific risks and corresponding discount rates. The cost approach considers factors including the value of the security's underlying assets and liabilities.

Investments in any open-end mutual funds are valued at their closing net asset value (NAV) each business day and are categorized as Level 1 in the hierarchy.

Changes in valuation techniques may result in transfers in or out of an assigned level within the disclosure hierarchy.

For additional information on the Fund's significant accounting policies, please refer to the Fund's most recent semiannual or annual shareholder report.

*The fund's schedule of investments as of the date on the cover of this report has not been audited. This report is provided for the general information of the fund's shareholders. For more information regarding the fund and its holdings, please see the fund's most recent prospectus and annual report.*

*Third party trademarks and service marks are the property of their respective owners. All other trademarks and service marks are the property of FMR LLC or an affiliate.*

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** Fidelity Select Portfolios

- **b. Investment Company Act file number:** 811-03114

- **c. CIK number of Registrant:** 0000320351

- **d. LEI of Registrant:** Z57125JG1LHEQKDYS630

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 245 Summer Street

  - **City:** Boston

  - **State:** MA

  - **Foreign country:** US

  - **Zip / Postal Code:** 02210

  - **Telephone number:** 1-800-FIDELITY

**Item A.2. Information about the Series.**

- **a. Name of Series:** Select Biotechnology Portfolio

- **b. EDGAR series identifier (if any):** S000007486

- **c. LEI of Series:** FQDPG178WXRZSXLIRG32

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2023-02-28

- **b. Date as of which information is reported:** 2022-11-30

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $5814686245.36

**Total Liabilities:** $464353645.35

**Net Assets:** $5350332600.01

**Cash Not Reported:** $932698.65

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000020460 | -2.15%               | 3.49%                | 3.12%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $-23337360.32            | $-84086181.65                              |
| Month 2  | $-72210945.22            | $245490120.19                              |
| Month 3  | $-194048068.91           | $357460272.98                              |

### Schedule of Portfolio Investments

| Name                               | Title                                                     | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| CHINOOK THERAPEUTICS INC           | CHINOOK THERAPEUTICS INC CVR RT                           | CUSIP: N/A<br>LEI: 549300X0O3003W5QYQ48       | Long             | EC               | CORP              | US        |    115821 | NS      | $1.16         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| TERNS PHARMACEUTICALS INC          | TERNS PHARMACEUTICALS INC                                 | CUSIP: 880881107<br>LEI: 254900S1ZDQMF4MYP709 | Long             | EC               | CORP              | US        |    810600 | NS      | $6298362.00   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| IDEAYA BIOSCIENCES INC             | IDEAYA BIOSCIENCES                                        | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |    715157 | NS      | $12787007.16  | 0.24%             |  |  |  | No            |                  1 | On Loan: —       |
| EXELIXIS INC                       | EXELIXIS INC                                              | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |   2102634 | NS      | $35912988.72  | 0.67%             |  |  |  | No            |                  1 | On Loan: No      |
| MORPHIC HOLDING INC                | MORPHIC HOLDING INC                                       | CUSIP: 61775R105<br>LEI: 549300RWWOUFLHTY1224 | Long             | EC               | CORP              | US        |    805337 | NS      | $22162874.24  | 0.41%             |  |  |  | No            |                  1 | On Loan: —       |
| SUTRO BIOPHARMA INC                | SUTRO BIOPHARMA INC                                       | CUSIP: 869367102<br>LEI: 5493005U6P15VD25P851 | Long             | EC               | CORP              | US        |    540100 | NS      | $4045349.00   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| AURA BIOSCIENCES INC               | AURA BIOSCIENCES INC                                      | CUSIP: 05153U107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    519959 | NS      | $7425014.52   | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| AMICUS THERAPEUTICS INC            | AMICUS THERAPEUTICS INC                                   | CUSIP: 03152W109<br>LEI: 549300MRD1SMUTNBPQ53 | Long             | EC               | CORP              | US        |   2261101 | NS      | $27359322.10  | 0.51%             |  |  |  | No            |                  1 | On Loan: —       |
| TWIST BIOSCIENCE CORP              | TWIST BIOSCIENCE CORP                                     | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |    681332 | NS      | $18634430.20  | 0.35%             |  |  |  | No            |                  1 | On Loan: —       |
| KRONOS BIO INC                     | KRONOS BIO INC                                            | CUSIP: 50107A104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    617758 | NS      | $1173740.20   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| BIOCRYST PHARMACEUTICALS INC       | BIOCRYST PHARMACEUTICALS INC                              | CUSIP: 09058V103<br>LEI: 549300Z0INP1Z5NP6J59 | Long             | EC               | CORP              | US        |   3649042 | NS      | $48751201.12  | 0.91%             |  |  |  | No            |                  1 | On Loan: —       |
| UNITED THERAPEUTICS CORP DEL       | UNITED THERAPEUTICS CORP DEL                              | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |    442409 | NS      | $123825855.01 | 2.31%             |  |  |  | No            |                  1 | On Loan: No      |
| AMGEN INC                          | AMGEN INC                                                 | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |    429703 | NS      | $123066939.20 | 2.30%             |  |  |  | No            |                  1 | On Loan: No      |
| HALOZYME THERAPEUTICS INC          | HALOZYME THERAPEUTICS INC                                 | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |    531800 | NS      | $30450868.00  | 0.57%             |  |  |  | No            |                  1 | On Loan: No      |
| IMMUNOGEN INC                      | IMMUNOGEN INC                                             | CUSIP: 45253H101<br>LEI: 54930084U0R1OP766Y02 | Long             | EC               | CORP              | US        |    922023 | NS      | $4785299.37   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| SAGE THERAPEUTICS INC              | SAGE THERAPEUTICS INC                                     | CUSIP: 78667J108<br>LEI: 5493000JX4BJS9W6CN35 | Long             | EC               | CORP              | US        |    699553 | NS      | $28709655.12  | 0.54%             |  |  |  | No            |                  1 | On Loan: No      |
| AXSOME THERAPEUTICS INC            | AXSOME THERAPEUTICS INC                                   | CUSIP: 05464T104<br>LEI: 549300EXGR0XLRJEIB95 | Long             | EC               | CORP              | US        |    242373 | NS      | $17521144.17  | 0.33%             |  |  |  | No            |                  1 | On Loan: —       |
| ABBVIE INC                         | ABBVIE INC                                                | CUSIP: 00287Y109<br>LEI: FR5LCKFTG8054YNNRU85 | Long             | EC               | CORP              | US        |   3617903 | NS      | $583133605.54 | 10.90%            |  |  |  | No            |                  1 | On Loan: No      |
| BIOXCEL THERAPEUTICS INC           | BIOXCEL THERAPEUTICS INC                                  | CUSIP: 09075P105<br>LEI: 549300Y25FYZ0E8LW260 | Long             | EC               | CORP              | US        |    351727 | NS      | $5828116.39   | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| ENTRADA THERAPEUTICS INC           | ENTRADA THERAPEUTICS INC                                  | CUSIP: 29384C108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    503853 | NS      | $7542679.41   | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| BLUEPRINT MEDICINES CORP           | BLUEPRINT MEDICINES CORP                                  | CUSIP: 09627Y109<br>LEI: 5299004CC60O9T5HVM83 | Long             | EC               | CORP              | US        |   1461508 | NS      | $69845467.32  | 1.31%             |  |  |  | No            |                  1 | On Loan: No      |
| VIGIL NEUROSCIENCE INC             | VIGIL NEUROSCIENCE INC                                    | CUSIP: 92673K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     86610 | NS      | $1082625.00   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| MANNKIND CORP                      | MANNKIND CORP                                             | CUSIP: 56400P706<br>LEI: 213800GFBCNY1ZFST722 | Long             | EC               | CORP              | US        |   6449301 | NS      | $30182728.68  | 0.56%             |  |  |  | No            |                  1 | On Loan: —       |
| AFFERENT PHARMA                    | AFFERENT PHARMACEUTICALS INC SER C PC PP                  | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |   8274568 | NS      | $82.75        | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ADVERUM BIOTECHNOLOGIES INC        | ADVERUM BIOTECHNOLOGIES INC                               | CUSIP: 00773U108<br>LEI: 529900ZEDOOZL1EWHJ89 | Long             | EC               | CORP              | US        |   8600677 | NS      | $5761593.52   | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| GRAPHITE BIO INC                   | GRAPHITE BIO INC                                          | CUSIP: 38870X104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1058457 | NS      | $3736353.21   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| CENTESSA PHARMACEUTICALS PLC       | CENTESSA PHARMACEUTICALS LTD ADR                          | CUSIP: 152309100<br>LEI: 213800GIDAARDSKOI827 | Long             | EC               | CORP              | GB        |   1230909 | NS      | $4923636.00   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| FOGHORN THERAPEUTICS INC           | FOGHORN THERAPEUTICS INC                                  | CUSIP: 344174107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    288942 | NS      | $1950358.50   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| ADC THERAPEUTICS SA                | ADC THERAPEUTICS SA                                       | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | CH        |    635838 | NS      | $2327167.08   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| FUSION PHARMACEUTICALS INC         | FUSION PHARMACEUTICALS INC                                | CUSIP: 36118A100<br>LEI: N/A                  | Long             | EC               | CORP              | CA        |   1142702 | NS      | $2593933.54   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| KINNATE BIOPHARMA INC              | KINNATE BIOPHARMA INC                                     | CUSIP: 49705R105<br>LEI: 549300YVIWV7HJ5WHI66 | Long             | EC               | CORP              | US        |   1811309 | NS      | $14345567.28  | 0.27%             |  |  |  | No            |                  1 | On Loan: —       |
| APPLIED THERAPEUTICS INC           | APPLIED THERAPEUTICS INC                                  | CUSIP: 03828A101<br>LEI: 549300KL3IJPHZM2GR04 | Long             | EC               | CORP              | US        |   2639536 | NS      | $2956280.32   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| XENCOR INC                         | XENCOR INC                                                | CUSIP: 98401F105<br>LEI: 549300V5IF65437JKG30 | Long             | EC               | CORP              | US        |    169343 | NS      | $5032873.96   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| TREVI THERAPEUTICS INC             | TREVI THERAPEUTICS INC                                    | CUSIP: 89532M101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1301455 | NS      | $2446735.40   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| SAREPTA THERAPEUTICS INC           | SAREPTA THERAPEUTICS INC                                  | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |    552604 | NS      | $67865297.24  | 1.27%             |  |  |  | No            |                  1 | On Loan: No      |
| TG THERAPEUTICS INC                | TG THERAPEUTICS INC                                       | CUSIP: 88322Q108<br>LEI: 529900X21UKABN9NJ529 | Long             | EC               | CORP              | US        |   1976220 | NS      | $17430260.40  | 0.33%             |  |  |  | No            |                  1 | On Loan: —       |
| CRINETICS PHARMACEUTICALS INC      | CRINETICS PHARMACEUTICALS INC                             | CUSIP: 22663K107<br>LEI: 549300Q1CNFXK5P31D28 | Long             | EC               | CORP              | US        |   1179587 | NS      | $21079219.69  | 0.39%             |  |  |  | No            |                  1 | On Loan: No      |
| ABSCI CORP                         | ABSCI CORP                                                | CUSIP: 00091E109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    997800 | NS      | $2494500.00   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| TENAYA THERAPEUTICS INC            | TENAYA THERAPEUTICS INC                                   | CUSIP: 87990A106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1263918 | NS      | $3349382.70   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| ENANTA PHARMACEUTICALS INC         | ENANTA PHARMACEUTICALS INC                                | CUSIP: 29251M106<br>LEI: 529900SSN4DODDQSN594 | Long             | EC               | CORP              | US        |    263946 | NS      | $11558195.34  | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| IVERIC BIO INC                     | IVERIC BIO INC                                            | CUSIP: 46583P102<br>LEI: 549300GZXI59U71XPM70 | Long             | EC               | CORP              | US        |    555584 | NS      | $13122894.08  | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| THESEUS PHARMACEUTICALS INC        | THESEUS PHARMACEUTICALS INC                               | CUSIP: 88369M101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1857891 | NS      | $12243501.69  | 0.23%             |  |  |  | No            |                  1 | On Loan: —       |
| INTRA-CELLULAR THERAPIES INC       | INTRA-CELLULAR THERAPIES INC                              | CUSIP: 46116X101<br>LEI: 5299002U2KGF193IJA20 | Long             | EC               | CORP              | US        |    557689 | NS      | $30237897.58  | 0.57%             |  |  |  | No            |                  1 | On Loan: No      |
| GERON CORP                         | GERON CORP WT 07/02/2024                                  | CUSIP: 374163129<br>LEI: 549300T282D7Z2YESL90 | Long             | EC               | CORP              | US        |   2100000 | NS      | $1396702.29   | 0.03%             |  |  |  | No            |                  2 | On Loan: No      |
| ITEOS THERAPEUTICS INC             | ITEOS THERAPEUTICS INC                                    | CUSIP: 46565G104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    238000 | NS      | $4795700.00   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| BIO AB HOLDINGS LLC                | BIO AB HOLDINGS LLC                                       | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |   1954526 | NS      | $78747852.54  | 1.47%             |  |  |  | Yes           |                  3 | On Loan: No      |
| IMMUNOCORE HOLDINGS PLC            | IMMUNOCORE HOLDINGS LTD ADR                               | CUSIP: 45258D105<br>LEI: 213800IUE3DFS84BVN18 | Long             | EC               | CORP              | GB        |    267318 | NS      | $16790243.58  | 0.31%             |  |  |  | No            |                  1 | On Loan: —       |
| AFFERENT PHARMA                    | AFFERENT PHARMACEUTICALS INC CONTINGENT VALUE RT 12/31/24 | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |   8274568 | NS      | $8605550.72   | 0.16%             |  |  |  | No            |                  3 | On Loan: No      |
| PLIANT THERAPEUTICS INC            | PLIANT THERAPEUTICS INC                                   | CUSIP: 729139105<br>LEI: 5493002Q5LITR7VHZH02 | Long             | EC               | CORP              | US        |    417606 | NS      | $7675598.28   | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| VALENZABIO INC                     | VALENZABIO INC SER A PC PP                                | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |   1685311 | NS      | $9993894.23   | 0.19%             |  |  |  | Yes           |                  3 | On Loan: No      |
| INTELLIA THERAPEUTICS INC          | INTELLIA THERAPEUTICS INC                                 | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |    885001 | NS      | $45542151.46  | 0.85%             |  |  |  | No            |                  1 | On Loan: No      |
| REGENERON PHARMACEUTICALS INC      | REGENERON PHARMACEUTICALS INC                             | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |    271706 | NS      | $204241400.20 | 3.82%             |  |  |  | No            |                  1 | On Loan: No      |
| PEPGEN INC                         | PEPGEN INC                                                | CUSIP: 713317105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    440591 | NS      | $6591241.36   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| RALLYBIO CORP                      | RALLYBIO CORP                                             | CUSIP: 75120L100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1550692 | NS      | $8931985.92   | 0.17%             |  |  |  | No            |                  1 | On Loan: —       |
| SALIOGEN THERAPEUTICS INC          | SALIOGEN THERAPEUTICS INC SER B PC PP                     | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |     94461 | NS      | $7043956.77   | 0.13%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ROIVANT SCIENCES LTD               | ROIVANT SCIENCES LTD PIPE                                 | CUSIP: N/A<br>LEI: 549300DL466NY5J6U724       | Long             | EC               | CORP              | BM        |   2500000 | NS      | $13400000.00  | 0.25%             |  |  |  | Yes           |                  1 | On Loan: No      |
| EQRX INC                           | EQRX INC 1 YR EARNOUT (CVR) RT                            | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |    116649 | NS      | $381442.23    | 0.01%             |  |  |  | No            |                  3 | On Loan: No      |
| OMEGA THERAPEUTICS INC             | OMEGA THERAPEUTICS INC                                    | CUSIP: 68217N105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    915541 | NS      | $6408787.00   | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| BIOMARIN PHARMACEUTICAL INC        | BIOMARIN PHARMACEUTICAL INC                               | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |    347448 | NS      | $35085299.04  | 0.66%             |  |  |  | No            |                  1 | On Loan: No      |
| KORRO BIO INC                      | KORRO BIO INC SER B-2 PC PP                               | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |    899280 | NS      | $1717624.80   | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ZENTALIS PHARMACEUTICALS INC       | ZENTALIS PHARMACEUTICALS LLC                              | CUSIP: 98943L107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    638433 | NS      | $14122137.96  | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| GEMINI THERAPEUTICS INC            | GEMINI THERAPEUTICS INC                                   | CUSIP: 36870G105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1555907 | NS      | $2676160.04   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| VERVE THERAPEUTICS INC             | VERVE THERAPEUTICS INC                                    | CUSIP: 92539P101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    249393 | NS      | $5793399.39   | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| ALDEYRA THERAPEUTICS INC           | ALDEYRA THERAPEUTICS INC                                  | CUSIP: 01438T106<br>LEI: 529900HGKY864E4Y9014 | Long             | EC               | CORP              | US        |    961337 | NS      | $5383487.20   | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| PROTHENA CORP PLC                  | PROTHENA CORP PLC                                         | CUSIP: N/A<br>LEI: 5299009ZXQ8NIIJ8OL30       | Long             | EC               | CORP              | IE        |    761589 | NS      | $47606928.39  | 0.89%             |  |  |  | No            |                  1 | On Loan: No      |
| BIOGEN INC                         | BIOGEN INC                                                | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |    703036 | NS      | $214545496.12 | 4.01%             |  |  |  | No            |                  1 | On Loan: No      |
| ARROWHEAD PHARMACEUTICALS INC      | ARROWHEAD PHARMACEUTICALS INC                             | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |   1923532 | NS      | $61937730.40  | 1.16%             |  |  |  | No            |                  1 | On Loan: No      |
| KRYSTAL BIOTECH INC                | KRYSTAL BIOTECH INC                                       | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |   2105960 | NS      | $163717330.40 | 3.06%             |  |  |  | No            |                  1 | On Loan: —       |
| ARVINAS INC                        | ARVINAS INC                                               | CUSIP: 04335A105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    395243 | NS      | $16220772.72  | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| GH RESEARCH PLC                    | GH RESEARCH PLC                                           | CUSIP: N/A<br>LEI: 875500HKJS7QQG6EWH62       | Long             | EC               | CORP              | IE        |    893124 | NS      | $9770776.56   | 0.18%             |  |  |  | No            |                  1 | On Loan: —       |
| OLINK HOLDING AB                   | OLINK HOLDING AB ADR                                      | CUSIP: 680710100<br>LEI: 8945004Z7ZHV3LML4J27 | Long             | EC               | CORP              | SE        |     57100 | NS      | $1360693.00   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| X4 PHARMACEUTICALS INC             | X4 PHARMACEUTICALS INC CL A WT 04/16/2024                 | CUSIP: 98420X111<br>LEI: 549300R0UFVPXWP86U94 | Long             | EC               | CORP              | US        |    450000 | NS      | $40.63        | 0.00%             |  |  |  | No            |                  2 | On Loan: No      |
| ARADIGM CORP                       | ARADIGM CORP PIPE                                         | CUSIP: N/A<br>LEI: 549300I46MRQ1CGCIY65       | Long             | EC               | CORP              | US        |    148009 | NS      | $6808.41      | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| SCHOLAR ROCK HOLDING CORP          | SCHOLAR ROCK HOLDING CORP                                 | CUSIP: 80706P103<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |   1693925 | NS      | $13161797.25  | 0.25%             |  |  |  | No            |                  1 | On Loan: —       |
| LONGBOARD PHARMACEUTICALS INC      | LONGBOARD PHARMACEUTICALS INC                             | CUSIP: 54300N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    371100 | NS      | $1992807.00   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| NURIX THERAPEUTICS INC             | NURIX THERAPEUTICS INC                                    | CUSIP: 67080M103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1056746 | NS      | $13093082.94  | 0.24%             |  |  |  | No            |                  1 | On Loan: —       |
| ARS PHARMACEUTICALS INC            | ARS PHARMACEUTICALS INC                                   | CUSIP: 82835W108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1675577 | NS      | $10422088.94  | 0.19%             |  |  |  | No            |                  1 | On Loan: —       |
| KEROS THERAPEUTICS INC             | KEROS THERAPEUTICS                                        | CUSIP: 492327101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    378977 | NS      | $18888213.68  | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| APELLIS PHARMACEUTICALS INC        | APELLIS PHARMACEUTICALS INC                               | CUSIP: 03753U106<br>LEI: 254900HS0ZFRXXSB9D42 | Long             | EC               | CORP              | US        |   1431684 | NS      | $71483982.12  | 1.34%             |  |  |  | No            |                  1 | On Loan: No      |
| ARGENX SE                          | ARGENX SE SPONSORED ADR                                   | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |    407247 | NS      | $162072088.59 | 3.03%             |  |  |  | No            |                  1 | On Loan: No      |
| ROYALTY PHARMA PLC                 | ROYALTY PHARMA PLC                                        | CUSIP: N/A<br>LEI: 549300FGFN7VOK8BZR03       | Long             | EC               | CORP              | GB        |    285820 | NS      | $12567505.40  | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| G1 THERAPEUTICS INC                | G1 THERAPEUTICS INC                                       | CUSIP: 3621LQ109<br>LEI: 529900TC35UPZQYRKW13 | Long             | EC               | CORP              | US        |    276904 | NS      | $1650347.84   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| GENERATION BIO CO                  | GENERATION BIO                                            | CUSIP: 37148K100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    137100 | NS      | $730743.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| CEREVEL THERAPEUTICS HOLDINGS INC  | CEREVEL THERAPEUTICS HOLDINGS INC                         | CUSIP: 15678U128<br>LEI: 254900RJNIRS9COSQR41 | Long             | EC               | CORP              | US        |   1044180 | NS      | $30239452.80  | 0.57%             |  |  |  | No            |                  1 | On Loan: —       |
| INSTIL BIO INC                     | INSTIL BIO INC                                            | CUSIP: 45783C101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1445074 | NS      | $1921948.42   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| CENTURY THERAPEUTICS INC           | CENTURY THERAPEUTICS INC                                  | CUSIP: 15673T100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    834618 | NS      | $8763489.00   | 0.16%             |  |  |  | No            |                  1 | On Loan: —       |
| REPLIMUNE GROUP INC                | REPLIMUNE GROUP INC                                       | CUSIP: 76029N106<br>LEI: 549300AY704NEIRC4K64 | Long             | EC               | CORP              | US        |    910817 | NS      | $18644423.99  | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| SEAGEN INC                         | SEAGEN INC                                                | CUSIP: 81181C104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    357732 | NS      | $43425087.48  | 0.81%             |  |  |  | No            |                  1 | On Loan: No      |
| KINIKSA PHARMACEUTICALS LTD        | KINIKSA PHARMACEUTICALS LTD                               | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | BM        |    177166 | NS      | $2981703.78   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| CYCLERION THERAPEUTICS INC         | CYCLERION THERAPEUTICS INC PP PIPE                        | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |     94809 | NS      | $90068.55     | 0.00%             |  |  |  | Yes           |                  1 | On Loan: No      |
| DICE THERAPEUTICS INC              | DICE MOLECULES HOLDING LLC                                | CUSIP: 23345J104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    451946 | NS      | $15732240.26  | 0.29%             |  |  |  | No            |                  1 | On Loan: —       |
| EDGEWISE THERAPEUTICS INC          | EDGEWISE THERAPEUTICS INC                                 | CUSIP: 28036F105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1722367 | NS      | $15415184.65  | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| DESIGN THERAPEUTICS INC            | DESIGN THERAPEUTICS INC                                   | CUSIP: 25056L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    806620 | NS      | $11292680.00  | 0.21%             |  |  |  | No            |                  1 | On Loan: —       |
| ULTRAGENYX PHARMACEUTICAL INC      | ULTRAGENYX PHARMA INC                                     | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |    978351 | NS      | $35514141.30  | 0.66%             |  |  |  | No            |                  1 | On Loan: No      |
| ALKERMES PLC                       | ALKERMES PLC                                              | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | IE        |    687536 | NS      | $17037142.08  | 0.32%             |  |  |  | No            |                  1 | On Loan: No      |
| ROCKET PHARMACEUTICALS INC         | ROCKET PHARMACEUTICALS INC                                | CUSIP: 77313F106<br>LEI: 549300R7VV82YUIN4Y93 | Long             | EC               | CORP              | US        |    223736 | NS      | $4224135.68   | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| SENSORION SA                       | SENSORION SA                                              | CUSIP: N/A<br>LEI: 969500P0W8XJ9CGZDP97       | Long             | EC               | CORP              | FR        |   2269877 | NS      | $1003805.35   | 0.02%             |  |  |  | No            |                  2 | On Loan: —       |
| SELECTA BIOSCIENCES INC            | SELECTA BIOSCIENCES INC                                   | CUSIP: 816212104<br>LEI: 529900NMN0LACZOL7C43 | Long             | EC               | CORP              | US        |    395568 | NS      | $518194.08    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| SPRINGWORKS THERAPEUTICS INC       | SPRINGWORKS THERAPEUTICS INC                              | CUSIP: 85205L107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    463711 | NS      | $11212531.98  | 0.21%             |  |  |  | No            |                  1 | On Loan: —       |
| MEDAVAIL HOLDINGS INC              | MYOS CORP PIPE                                            | CUSIP: N/A<br>LEI: 549300ZNQGSJ2V3ZB668       | Long             | EC               | CORP              | US        |      2777 | NS      | $1163.84      | 0.00%             |  |  |  | Yes           |                  1 | On Loan: No      |
| GUARDANT HEALTH INC                | GUARDANT HEALTH INC                                       | CUSIP: 40131M109<br>LEI: 254900M8C3E5VC8BR186 | Long             | EC               | CORP              | US        |     82500 | NS      | $4318050.00   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| POSEIDA THERAPEUTICS INC           | POSEIDA THERAPEUTICS INC                                  | CUSIP: 73730P108<br>LEI: 549300USKSDMNGMN8V04 | Long             | EC               | CORP              | US        |    570083 | NS      | $2599578.48   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| TYRA BIOSCIENCES INC               | TYRA BIOSCIENCES INC                                      | CUSIP: 90240B106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    342201 | NS      | $2398829.01   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| CHINOOK THERAPEUTICS INC           | CHINOOK THERAPEUTICS INC                                  | CUSIP: 16961L106<br>LEI: 549300X0O3003W5QYQ48 | Long             | EC               | CORP              | US        |    303781 | NS      | $6880639.65   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| ARADIGM CORP                       | ARADIGM CORP                                              | CUSIP: N/A<br>LEI: 549300I46MRQ1CGCIY65       | Long             | EC               | CORP              | US        |     11945 | NS      | $549.47       | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| NOVOCURE LTD                       | NOVOCURE LTD                                              | CUSIP: N/A<br>LEI: 213800YPP55UMHWA4826       | Long             | EC               | CORP              | JE        |     11113 | NS      | $853922.92    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| UNIQURE N.V.                       | UNIQURE N.V.                                              | CUSIP: N/A<br>LEI: 724500RPCTZLFYJZ3S98       | Long             | EC               | CORP              | NL        |    255608 | NS      | $6763387.68   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| SHATTUCK LABS INC                  | SHATTUCK LABS INC                                         | CUSIP: 82024L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    110936 | NS      | $251824.72    | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| AVIDITY BIOSCIENCES INC            | AVIDITY BIOSCIENCES                                       | CUSIP: 05370A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    476750 | NS      | $5549370.00   | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| BIONTECH SE                        | BIONTECH SE ADR                                           | CUSIP: 09075V102<br>LEI: 894500UZJ5LG1F8J1U58 | Long             | EC               | CORP              | DE        |    195228 | NS      | $32606980.56  | 0.61%             |  |  |  | No            |                  1 | On Loan: No      |
| ARCUTIS BIOTHERAPEUTICS INC        | ARCUTIS BIOTHERAPEUTICS INC                               | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    894174 | NS      | $15406618.02  | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| INHIBRX INC                        | INHIBRX INC                                               | CUSIP: 45720L107<br>LEI: 549300VBKG2LTV1TLY22 | Long             | EC               | CORP              | US        |    254309 | NS      | $7624183.82   | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| JANUX THERAPEUTICS INC             | JANUX THERAPEUTICS INC                                    | CUSIP: 47103J105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    718391 | NS      | $9798853.24   | 0.18%             |  |  |  | No            |                  1 | On Loan: —       |
| ALLOGENE THERAPEUTICS INC          | ALLOGENE THERAPEUTICS INC                                 | CUSIP: 019770106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1556685 | NS      | $15348914.10  | 0.29%             |  |  |  | No            |                  1 | On Loan: —       |
| FATE THERAPEUTICS INC              | FATE THERAPEUTICS INC                                     | CUSIP: 31189P102<br>LEI: 549300L14Q4UHOODLA90 | Long             | EC               | CORP              | US        |    608787 | NS      | $12674945.34  | 0.24%             |  |  |  | No            |                  1 | On Loan: —       |
| RELAY THERAPEUTICS INC             | RELAY THERAPEUTICS INC                                    | CUSIP: 75943R102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    770589 | NS      | $14317543.62  | 0.27%             |  |  |  | No            |                  1 | On Loan: —       |
| PRELUDE THERAPEUTICS INC           | PRELUDE THERAPEUTICS INC                                  | CUSIP: 74065P101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    359156 | NS      | $2395570.52   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| REVOLUTION MEDICINES INC           | REVOLUTION MEDICINES INC                                  | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |    418772 | NS      | $9878831.48   | 0.18%             |  |  |  | No            |                  1 | On Loan: —       |
| BRIDGEBIO PHARMA INC               | BRIDGEBIO PHARMA INC                                      | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |    613842 | NS      | $5751699.54   | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| GOSSAMER BIO INC                   | GOSSAMER BIO INC                                          | CUSIP: 38341P102<br>LEI: 549300ZOC0N2W6PSFR58 | Long             | EC               | CORP              | US        |   1687174 | NS      | $14442209.44  | 0.27%             |  |  |  | No            |                  1 | On Loan: —       |
| CINCOR PHARMA INC                  | CINCOR PHARMA INC                                         | CUSIP: 17240Y109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     81593 | NS      | $962797.40    | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| NUVATION BIO INC                   | NUVATION BIO INC                                          | CUSIP: 67080N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    727400 | NS      | $1389334.00   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| SCHRODINGER INC                    | SCHRODINGER INC                                           | CUSIP: 80810D103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    199427 | NS      | $3589686.00   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| INCYTE CORP                        | INCYTE CORP                                               | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |    427600 | NS      | $34066892.00  | 0.64%             |  |  |  | No            |                  1 | On Loan: No      |
| VAXCYTE INC                        | VAXCYTE INC                                               | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |   1355250 | NS      | $62422815.00  | 1.17%             |  |  |  | No            |                  1 | On Loan: No      |
| MODERNA INC                        | MODERNA INC                                               | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |    918386 | NS      | $161553281.26 | 3.02%             |  |  |  | No            |                  1 | On Loan: No      |
| ORIC PHARMACEUTICALS INC           | ORIC PHARMACEUTICALS INC                                  | CUSIP: 68622P109<br>LEI: 54930033FJRNEYBW0L25 | Long             | EC               | CORP              | US        |    148239 | NS      | $532178.01    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| HORIZON THERAPEUTICS PLC           | HORIZON THERAPEUTICS PLC                                  | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | IE        |    320147 | NS      | $32107542.63  | 0.60%             |  |  |  | No            |                  1 | On Loan: No      |
| BIOINVENT INTERNATIONAL AB         | BIOINVENT AB                                              | CUSIP: N/A<br>LEI: 549300E7QRHEF2IJUY10       | Long             | EC               | CORP              | SE        |    788706 | NS      | $2708350.80   | 0.05%             |  |  |  | No            |                  2 | On Loan: No      |
| TANGO THERAPEUTICS INC             | TANGO THERAPEUTICS INC                                    | CUSIP: 87583X109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1463188 | NS      | $10988541.88  | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| PROMETHEUS BIOSCIENCES INC         | PROMETHEUS BIOSCIENCES INC                                | CUSIP: 74349U108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    342555 | NS      | $14082436.05  | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| ALPHA TAU MEDICAL LTD              | ALPHA TAU MEDICAL LTD CL A                                | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | IL        |    362046 | NS      | $1444563.54   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| CANDEL THERAPEUTICS INC            | CANDEL THERAPEUTICS INC                                   | CUSIP: 137404109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    737596 | NS      | $1290793.00   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| 23ANDME HOLDING CO                 | 23ANDME HOLDING CO CL A                                   | CUSIP: 90138Q108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2046974 | NS      | $6243270.70   | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| VERA THERAPEUTICS INC              | VERA THERAPEUTICS INC                                     | CUSIP: 92337R101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    779768 | NS      | $13022125.60  | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| VERONA PHARMA PLC                  | VERONA PHARMA PLC ADR                                     | CUSIP: 925050106<br>LEI: 213800EVI6O6J3TIAL06 | Long             | EC               | CORP              | GB        |    290000 | NS      | $3741000.00   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| IDORSIA LTD                        | IDORSIA LTD                                               | CUSIP: N/A<br>LEI: 506700XOVZUB107S5720       | Long             | EC               | CORP              | CH        |   1092661 | NS      | $16200657.16  | 0.30%             |  |  |  | No            |                  2 | On Loan: —       |
| EVELO BIOSCIENCES INC              | EVELO BIOSCIENCES INC                                     | CUSIP: 299734103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1098999 | NS      | $2296907.91   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| CYTEIR THERAPEUTICS INC            | CYTEIR THERAPEUTICS INC                                   | CUSIP: 23284P103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    451123 | NS      | $649617.12    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| ATEA PHARMACEUTICALS INC           | ATEA PHARMACEUTICALS INC                                  | CUSIP: 04683R106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     66800 | NS      | $313292.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| ALLOVIR INC                        | ALLOVIR INC                                               | CUSIP: 019818103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    852383 | NS      | $6401396.33   | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| KORRO BIO INC                      | KORRO BIO INC SER B-1 PC PP                               | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |    957854 | NS      | $1829501.14   | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| VERRICA PHARMACEUTICALS INC        | VERRICA PHARMACEUTICALS INC                               | CUSIP: 92511W108<br>LEI: 5493002L68H6THU5GW50 | Long             | EC               | CORP              | US        |   1597876 | NS      | $5193097.00   | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| EQRX INC                           | EQRX INC 2 YR EARNOUT (CVR) RT                            | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |     49993 | NS      | $132981.38    | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| ROIVANT SCIENCES LTD               | ROIVANT SCIENCES LTD                                      | CUSIP: N/A<br>LEI: 549300DL466NY5J6U724       | Long             | EC               | CORP              | BM        |   5957525 | NS      | $31932334.00  | 0.60%             |  |  |  | No            |                  1 | On Loan: —       |
| REPARE THERAPEUTICS INC            | REPARE THERAPEUTICS INC                                   | CUSIP: 760273102<br>LEI: N/A                  | Long             | EC               | CORP              | CA        |    174960 | NS      | $2804608.80   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| IKENA ONCOLOGY INC                 | IKENA ONCOLOGY INC                                        | CUSIP: 45175G108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    416547 | NS      | $928899.81    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| HOOKIPA PHARMA INC                 | HOOKIPA PHARMA INC                                        | CUSIP: 43906K100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1480200 | NS      | $1569012.00   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| KARUNA THERAPEUTICS INC            | KARUNA THERAPEUTICS INC                                   | CUSIP: 48576A100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    393512 | NS      | $92597308.72  | 1.73%             |  |  |  | No            |                  1 | On Loan: No      |
| AEROVATE THERAPEUTICS INC          | AEROVATE THERAPEUTICS INC                                 | CUSIP: 008064107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     77051 | NS      | $1451640.84   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| PROTAGONIST THERAPEUTICS INC       | PROTAGONIST THERAPEUTICS INC                              | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    144827 | NS      | $1145581.57   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| VENTYX BIOSCIENCES INC             | VENTYX BIOSCIENCES INC                                    | CUSIP: 92332V107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    716630 | NS      | $20775103.70  | 0.39%             |  |  |  | No            |                  1 | On Loan: —       |
| CYTOKINETICS INC                   | CYTOKINETICS INC                                          | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |   2154571 | NS      | $91569267.50  | 1.71%             |  |  |  | No            |                  1 | On Loan: —       |
| ATYR PHARMA INC                    | ATYR PHARMA INC                                           | CUSIP: 002120202<br>LEI: 529900ENQUXMC5EBKO36 | Long             | EC               | CORP              | US        |   1146952 | NS      | $2477416.32   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| NATIONAL RESILIENCE INC            | NATIONAL RESILIENCE INC SER B PC PP                       | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |    732064 | NS      | $44458246.72  | 0.83%             |  |  |  | Yes           |                  3 | On Loan: No      |
| SCHOLAR ROCK HOLDING CORP          | SCHOLAR ROCK HOLDING CORP WT 12/31/2025 PP                | CUSIP: N/A<br>LEI: 549300Z1FLPGL4OWJ459       | Long             | EC               | CORP              | US        |     17850 | NS      | $55193.23     | 0.00%             |  |  |  | Yes           |                  2 | On Loan: No      |
| ALECTOR INC                        | ALECTOR INC                                               | CUSIP: 014442107<br>LEI: 549300Z8RQOIY1JMHC25 | Long             | EC               | CORP              | US        |    914318 | NS      | $7762559.82   | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| ARISTEA THERAPEUTICS INC           | ARISTEA THERAPEUTICS INC SER B PC PP                      | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |    836400 | NS      | $6431916.00   | 0.12%             |  |  |  | Yes           |                  3 | On Loan: No      |
| AMBRX BIOPHARMA INC                | AMBRX BIOPHARMA INC ADR                                   | CUSIP: 02290A102<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |   1361508 | NS      | $667070.84    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| ORAGENICS INC                      | ORAGENICS INC PIPE                                        | CUSIP: N/A<br>LEI: 549300639MGD19K4ZW90       | Long             | EC               | CORP              | US        |    155806 | NS      | $30662.62     | 0.00%             |  |  |  | Yes           |                  1 | On Loan: No      |
| Fidelity Revere Street Trust       | Fidelity Cash Central Fund                                | CUSIP: 31635A105<br>LEI: 549300BDV45LJNXBZC55 | Long             | STIV             | RF                | US        |   9911593 | NS      | $9913574.83   | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| WAVE LIFE SCIENCES LTD             | WAVE LIFE SCIENCES LTD                                    | CUSIP: N/A<br>LEI: 54930070006GPKFYZ813       | Long             | EC               | CORP              | SG        |   1696733 | NS      | $7194147.92   | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| ASCENDIS PHARMA A/S                | ASCENDIS PHARMA AS SPON ADR                               | CUSIP: 04351P101<br>LEI: 549300B66JN3W3J8GH73 | Long             | EC               | CORP              | DK        |    659409 | NS      | $81146871.54  | 1.52%             |  |  |  | No            |                  1 | On Loan: —       |
| LEGEND BIOTECH CORP                | LEGEND BIOTECH CORP SPON ADR                              | CUSIP: 52490G102<br>LEI: 254900EIUFZTW136H859 | Long             | EC               | CORP              | KY        |    912716 | NS      | $47014001.16  | 0.88%             |  |  |  | No            |                  1 | On Loan: No      |
| 4D MOLECULAR THERAPEUTICS INC      | 4D MOLECULAR THERAPEUTICS INC                             | CUSIP: 35104E100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     24264 | NS      | $586460.88    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| GERON CORP                         | GERON CORP                                                | CUSIP: 374163103<br>LEI: 549300T282D7Z2YESL90 | Long             | EC               | CORP              | US        |    174306 | NS      | $404389.92    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| RECURSION PHARMACEUTICALS INC      | RECURSION PHARMACEUTICALS INC                             | CUSIP: 75629V104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     89200 | NS      | $838480.00    | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| VOR BIOPHARMA INC                  | VOR BIOPHARMA INC                                         | CUSIP: 929033108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    696659 | NS      | $3204631.40   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| ADICET BIO INC                     | ADICET BIO INC                                            | CUSIP: 007002108<br>LEI: 549300VRD2QO80WBOP18 | Long             | EC               | CORP              | US        |    713361 | NS      | $12968902.98  | 0.24%             |  |  |  | No            |                  1 | On Loan: —       |
| COMPASS THERAPEUTICS INC           | COMPASS THERAPEUTICS INC                                  | CUSIP: 20454B104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2232400 | NS      | $9175164.00   | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| RAIN THERAPEUTICS INC              | RAIN THERAPEUTICS INC                                     | CUSIP: 75082Q105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    206669 | NS      | $1595484.68   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| REGULUS THERAPEUTICS INC           | REGULUS THERAPEUTICS INC                                  | CUSIP: 75915K309<br>LEI: 529900ZYH2KYFH6Z7098 | Long             | EC               | CORP              | US        |   2195000 | NS      | $3753450.00   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| VERTEX PHARMACEUTICALS INC         | VERTEX PHARMACEUTICALS INC                                | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |    709810 | NS      | $224583884.00 | 4.20%             |  |  |  | No            |                  1 | On Loan: No      |
| REATA PHARMACEUTICALS INC          | REATA PHARMACEUTICALS INC CL A                            | CUSIP: 75615P103<br>LEI: 5299005F094GH9QDDD80 | Long             | EC               | CORP              | US        |    381628 | NS      | $15104836.24  | 0.28%             |  |  |  | No            |                  1 | On Loan: —       |
| SCORPION THERAPEUTICS INC          | SCORPION THERAPEUTICS INC SER B PC PP                     | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |   3099905 | NS      | $3874881.25   | 0.07%             |  |  |  | Yes           |                  3 | On Loan: No      |
| BIOHAVEN LTD                       | BIOHAVEN LTD                                              | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | VG        |   2823752 | NS      | $44671756.64  | 0.83%             |  |  |  | No            |                  1 | On Loan: —       |
| AXCELLA HEALTH INC                 | AXCELLA HEALTH INC                                        | CUSIP: 05454B105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1661354 | NS      | $1396201.90   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| NATERA INC                         | NATERA INC                                                | CUSIP: 632307104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    356133 | NS      | $14644188.96  | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| OPTINOSE INC                       | OPTINOSE INC WT 11/23/27                                  | CUSIP: 68404V118<br>LEI: 549300CPBME7Z3CYMN16 | Long             | EC               | CORP              | US        |     91712 | NS      | $59515.57     | 0.00%             |  |  |  | No            |                  2 | On Loan: No      |
| PHARVARIS BV                       | PHARVARIS BV                                              | CUSIP: N/A<br>LEI: 9845003BE146D3B75D32       | Long             | EC               | CORP              | NL        |    353507 | NS      | $728224.42    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| NKARTA INC                         | NKARTA INC                                                | CUSIP: 65487U108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    244766 | NS      | $2075615.68   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| MADRIGAL PHARMACEUTICALS INC       | MADRIGAL PHARMACEUTICALS INC                              | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |    153140 | NS      | $10736645.40  | 0.20%             |  |  |  | No            |                  1 | On Loan: —       |
| BELLUS HEALTH INC NEW              | BELLUS HEALTH INC                                         | CUSIP: 07987C204<br>LEI: 549300QZYQDSMOXCP667 | Long             | EC               | CORP              | CA        |   2069064 | NS      | $20421661.68  | 0.38%             |  |  |  | No            |                  1 | On Loan: No      |
| ICOSAVAX INC                       | ICOSAVAX INC                                              | CUSIP: 45114M109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    490857 | NS      | $1639462.38   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC THERAPEUTICS INC               | PTC THERAPEUTICS INC                                      | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |   2267944 | NS      | $94096996.56  | 1.76%             |  |  |  | No            |                  1 | On Loan: No      |
| CODIAK BIOSCIENCES INC             | CODIAK BIOSCIENCES INC                                    | CUSIP: 192010106<br>LEI: 549300QVVVW74Y10Q230 | Long             | EC               | CORP              | US        |    448539 | NS      | $309536.76    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| BICYCLE THERAPEUTICS PLC           | BICYCLE THERAPEUTICS LTD ADR                              | CUSIP: 088786108<br>LEI: 213800XKUI6R7GKC3E43 | Long             | EC               | CORP              | GB        |    377647 | NS      | $10936657.12  | 0.20%             |  |  |  | No            |                  1 | On Loan: —       |
| IMMUNEERING CORP                   | IMMUNEERING CORP                                          | CUSIP: 45254E107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    190327 | NS      | $1235222.23   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| ARCELLX INC                        | ARCELLX INC                                               | CUSIP: 03940C100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    605400 | NS      | $12071676.00  | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| STOKE THERAPEUTICS INC             | STOKE THERAPEUTICS INC                                    | CUSIP: 86150R107<br>LEI: 549300RD25SS2DIJHJ67 | Long             | EC               | CORP              | US        |    203036 | NS      | $1530891.44   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| DAY ONE BIOPHARMACEUTICALS INC     | DAY ONE BIOPHARMACEUTICALS INC                            | CUSIP: 23954D109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    845671 | NS      | $17953595.33  | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| UCB SA                             | UCB SA                                                    | CUSIP: N/A<br>LEI: 2138008J191VLSGY5A09       | Long             | EC               | CORP              | BE        |    121277 | NS      | $9789060.11   | 0.18%             |  |  |  | No            |                  2 | On Loan: No      |
| RHYTHM PHARMACEUTICALS INC         | RHYTHM PHARMACEUTICALS INC                                | CUSIP: 76243J105<br>LEI: 529900JPNWXQ8DPLA551 | Long             | EC               | CORP              | US        |    826303 | NS      | $22120131.31  | 0.41%             |  |  |  | No            |                  1 | On Loan: —       |
| DYNE THERAPEUTICS INC              | DYNE THERAPEUTICS INC                                     | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    310813 | NS      | $3636512.10   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| SERES THERAPEUTICS INC             | SERES THERAPEUTICS INC                                    | CUSIP: 81750R102<br>LEI: 549300GMXBE5NUWISF13 | Long             | EC               | CORP              | US        |    854347 | NS      | $5553255.50   | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| SPRINGWORKS THERAPEUTICS INC       | SPRINGWORKS THERAPEUTICS INC PIPE                         | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |     54800 | NS      | $1192557.60   | 0.02%             |  |  |  | Yes           |                  2 | On Loan: No      |
| IGM BIOSCIENCES INC                | IGM BIOSCIENCES INC                                       | CUSIP: 449585108<br>LEI: 5493008XCQES2N0VY969 | Long             | EC               | CORP              | US        |    561231 | NS      | $12352694.31  | 0.23%             |  |  |  | No            |                  1 | On Loan: —       |
| ALNYLAM PHARMACEUTICALS INC        | ALNYLAM PHARMACEUTICALS INC                               | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |   1100139 | NS      | $242679662.01 | 4.54%             |  |  |  | No            |                  1 | On Loan: No      |
| HARMONY BIOSCIENCES HOLDINGS INC   | HARMONY BIOSCIENCES HOLDINGS INC                          | CUSIP: 413197104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    135325 | NS      | $8088375.25   | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| ZEALAND PHARMA A/S                 | ZEALAND PHARMA A/S                                        | CUSIP: N/A<br>LEI: 549300ITBB1ULBL4CZ12       | Long             | EC               | CORP              | DK        |    375400 | NS      | $10746405.03  | 0.20%             |  |  |  | No            |                  2 | On Loan: —       |
| CORCEPT THERAPEUTICS INC           | CORCEPT THERAPEUTICS INC                                  | CUSIP: 218352102<br>LEI: 529900EO9LUTFMZ7FF90 | Long             | EC               | CORP              | US        |    164400 | NS      | $4156032.00   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Fidelity Revere Street Trust       | Fidelity Securities Lending Cash Central Fund             | CUSIP: 31635A303<br>LEI: 549300BDV45LJNXBZC55 | Long             | STIV             | RF                | US        | 458697423 | NS      | $458743293.02 | 8.57%             |  |  |  | No            |                  1 | On Loan: No      |
| CODIAK BIOSCIENCES INC             | CODIAK BIOSCIENCES INC WT 09/15/2027                      | CUSIP: N/A<br>LEI: 549300QVVVW74Y10Q230       | Long             | EC               | CORP              | US        |     46000 | NS      | $6216.52      | 0.00%             |  |  |  | No            |                  2 | On Loan: No      |
| KYMERA THERAPEUTICS INC            | KYMERA THERAPEUTICS INC                                   | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1072813 | NS      | $31090120.74  | 0.58%             |  |  |  | No            |                  1 | On Loan: —       |
| OPTINOSE INC                       | OPTINOSE INC                                              | CUSIP: 68404V100<br>LEI: 549300CPBME7Z3CYMN16 | Long             | EC               | CORP              | US        |    794031 | NS      | $1405434.87   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| MIRATI THERAPEUTICS INC            | Mirati Therapeutics Inc                                   | CUSIP: 60468T105<br>LEI: 529900GYRW59IDQV6N54 | Long             | EC               | CORP              | US        |    662148 | NS      | $60507084.24  | 1.13%             |  |  |  | No            |                  1 | On Loan: No      |
| BEAM THERAPEUTICS INC              | BEAM THERAPEUTICS INC                                     | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    528692 | NS      | $24420283.48  | 0.46%             |  |  |  | No            |                  1 | On Loan: —       |
| XENON PHARMACEUTICALS INC          | XENON PHARMACEUTICALS INC                                 | CUSIP: 98420N105<br>LEI: 549300XV44Q9Z1MIPQ03 | Long             | EC               | CORP              | CA        |   1004333 | NS      | $37039801.04  | 0.69%             |  |  |  | No            |                  1 | On Loan: No      |
| TRAVERE THERAPEUTICS INC           | TRAVERE THERAPEUTICS INC                                  | CUSIP: 89422G107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    300428 | NS      | $6047615.64   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| ANAPTYSBIO INC                     | ANAPTYSBIO INC                                            | CUSIP: 032724106<br>LEI: 529900HH4WQT03IG1A12 | Long             | EC               | CORP              | US        |    273328 | NS      | $7552052.64   | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| CRISPR THERAPEUTICS AG             | CRISPR THERAPEUTICS AG                                    | CUSIP: N/A<br>LEI: 506700O6IRRIQLT3W370       | Long             | EC               | CORP              | CH        |    305022 | NS      | $16712155.38  | 0.31%             |  |  |  | No            |                  1 | On Loan: —       |
| COGENT BIOSCIENCES INC             | COGENT BIOSCIENCES INC                                    | CUSIP: 19240Q201<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1139767 | NS      | $14338268.86  | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| DENALI THERAPEUTICS INC            | DENALI THERAPEUTICS INC                                   | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |    417851 | NS      | $13333625.41  | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| CYCLERION THERAPEUTICS INC         | CYCLERION THERAPEUTICS INC                                | CUSIP: 23255M105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    837285 | NS      | $795420.75    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| GRITSTONE BIO INC                  | GRITSTONE BIO INC                                         | CUSIP: 39868T105<br>LEI: 5493003TER6KY3MUVY84 | Long             | EC               | CORP              | US        |    431580 | NS      | $1268845.20   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| INSMED INC                         | INSMED INC                                                | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |    647392 | NS      | $11970278.08  | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| EQRX INC                           | EQRX INC                                                  | CUSIP: 26886C107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    507567 | NS      | $1908451.92   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| GILEAD SCIENCES INC                | GILEAD SCIENCES INC                                       | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |    437804 | NS      | $38452325.32  | 0.72%             |  |  |  | No            |                  1 | On Loan: No      |
| ALX ONCOLOGY HOLDINGS INC          | ALX ONCOLOGY HOLDINGS INC                                 | CUSIP: 00166B105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1280549 | NS      | $14214093.90  | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| TAYSHA GENE THERAPIES INC          | TAYSHA GENE THERAPIES INC                                 | CUSIP: 877619106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    811647 | NS      | $1793739.87   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| ALLENA PHARMACEUTICALS INC         | ALLENA PHARMACEUTICALS INC                                | CUSIP: 018119107<br>LEI: 549300749HO5QS40BX97 | Long             | EC               | CORP              | US        |     93683 | NS      | $1096.09      | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| MORPHOSYS AG                       | MORPHOSYS AG SPONSORED ADR                                | CUSIP: 617760202<br>LEI: 529900493806K77LRE72 | Long             | EC               | CORP              | DE        |    217028 | NS      | $894155.36    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| BIOMEA FUSION INC                  | BIOMEA FUSION INC                                         | CUSIP: 09077A106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    407129 | NS      | $2927257.51   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| MERUS NV                           | MERUS B.V.                                                | CUSIP: N/A<br>LEI: 549300W8GPUWU8QNU293       | Long             | EC               | CORP              | NL        |    458686 | NS      | $7040830.10   | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| ERASCA INC                         | ERASCA INC                                                | CUSIP: 29479A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    639223 | NS      | $4826133.65   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| CELLDEX THERAPEUTICS INC           | CELLDEX THERAPEUTICS INC                                  | CUSIP: 15117B202<br>LEI: 529900F018DMYWH38923 | Long             | EC               | CORP              | US        |    819700 | NS      | $30402673.00  | 0.57%             |  |  |  | No            |                  1 | On Loan: No      |
| ELEVATEBIO, LLC                    | ELEVATEBIO LLC SER C PC PP                                | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |    216600 | NS      | $990511.80    | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| IONIS PHARMACEUTICALS INC          | IONIS PHARMACEUTICALS INC                                 | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |   1123677 | NS      | $45834784.83  | 0.86%             |  |  |  | No            |                  1 | On Loan: No      |
| NUVALENT INC                       | NUVALENT INC-A                                            | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    218574 | NS      | $7186713.12   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| MONTE ROSA THERAPEUTICS INC        | MONTE ROSA THERAPEUTICS INC                               | CUSIP: 61225M102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1257805 | NS      | $10666186.40  | 0.20%             |  |  |  | No            |                  1 | On Loan: —       |
| 2SEVENTY BIO INC                   | 2SEVENTY BIO INC-W/I                                      | CUSIP: 901384107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    103752 | NS      | $1625793.84   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| ARCUS BIOSCIENCES INC              | ARCUS BIOSCIENCES INC                                     | CUSIP: 03969F109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   3193396 | NS      | $112311737.32 | 2.10%             |  |  |  | No            |                  1 | On Loan: —       |
| ARCTURUS THERAPEUTICS HOLDINGS INC | ARCTURUS THERAPEUTICS HOLDINGS INC                        | CUSIP: 03969T109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    875824 | NS      | $16150194.56  | 0.30%             |  |  |  | No            |                  1 | On Loan: —       |
| SEER INC                           | SEER INC                                                  | CUSIP: 81578P106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    304058 | NS      | $1964214.68   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| RAPT THERAPEUTICS INC              | RAPT THERAPEUTICS INC                                     | CUSIP: 75382E109<br>LEI: 549300MB473BIU78ES48 | Long             | EC               | CORP              | US        |    750682 | NS      | $13272057.76  | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| FULCRUM THERAPEUTICS INC           | FULCRUM THERAPEUTICS INC                                  | CUSIP: 359616109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1655989 | NS      | $11343524.65  | 0.21%             |  |  |  | No            |                  1 | On Loan: —       |

### Signature

**Date Signed:** 2022-12-30

**Name of Applicant:** Stacie M. Smith

**Signature:** Stacie M. Smith

**Name of Signer:** Stacie M. Smith

**Title:** President and Treasurer