# EDGAR Filing Document

**Accession Number:** 0001429560
**File Stem:** 0001104659-23-006308
**Filing Date:** 2023-1
**Character Count:** 25809
**Document Hash:** bf9d0aea64e7a99e653523b3c8d83683
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-23-006308.hdr.sgml**: 20230125

**ACCESSION NUMBER**: 0001104659-23-006308

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 6

**FILED AS OF DATE**: 20230125

**DATE AS OF CHANGE**: 20230124

**EFFECTIVENESS DATE**: 20230125

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** TREVENA INC
- **CENTRAL INDEX KEY:** 0001429560
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-269396
- **FILM NUMBER:** 23549497

**BUSINESS ADDRESS:**
- **STREET 1:** 955 CHESTERBROOK BOULEVARD
- **STREET 2:** SUITE 110
- **CITY:** CHESTERBROOK
- **STATE:** PA
- **ZIP:** 19087
- **BUSINESS PHONE:** 6103548840

**MAIL ADDRESS:**
- **STREET 1:** 955 CHESTERBROOK BOULEVARD
- **STREET 2:** SUITE 110
- **CITY:** CHESTERBROOK
- **STATE:** PA
- **ZIP:** 19087

**As filed with the Securities and Exchange Commission on January 25, 2023**

**Registration No. 333-** 

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**Washington, D.C. 20549**

**Form S-8**

**REGISTRATION STATEMENT** 

***UNDER***

***THE SECURITIES ACT OF 1933***

 ****

**Trevena, Inc.**

**(Exact name of registrant as specified in its charter)**

---

| | |
|:---|:---|
| **Delaware** | **26-1469215** |
| **(State or other jurisdiction of**<br> **incorporation or organization)** | **(IRS employer**<br> **identification number)** |

---

---

| | |
|:---|:---|
| **955 Chesterbrook Blvd., Suite 110**<br> **Chesterbrook, Pennsylvania** | **19087** |
| **(Address of Principal Executive Offices)** | **(Zip Code)** |

---

**2013 Equity Incentive Plan**

**(Full titles of the plans)** 

**Carrie L. Bourdow**

**President and Chief Executive Officer**

**Trevena, Inc.**

**955 Chesterbrook Blvd., Suite 110**

**Chesterbrook, Pennsylvania 19087**

**(610) 354-8840**

**(Name, address, including zip code and telephone number, including area code, of agent for service)**

***Copies to:***

---

| | |
|:---|:---|
| **Brian M. Katz, Esq.<br> Scott R. Jones, Esq.<br> Troutman Pepper Hamilton Sanders LLP<br> 3000 Two Logan Square<br> Philadelphia, PA 19103<br> Telephone: (215) 981-4000** | **Barry Shin**<br> **Chief Financial Officer<br> Trevena, Inc.<br> 955 Chesterbrook Blvd., Suite 110<br> Chesterbrook, PA 19087<br> (610) 354-8840** |

---

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

Large accelerated filer ◻ Accelerated filer ◻ <br> Non-accelerated filer ⌧ Smaller reporting company ⌧ <br> Emerging growth company ◻

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ◻

**PART I**

**EXPLANATORY NOTE**

This Registration Statement on Form S-8 is being filed for the purpose of registering an additional 309,363 shares of the Common Stock of Trevena, Inc. (the "Registrant") to be issued pursuant to the annual automatic increase provision set forth in Section 3(a) of the Registrant's 2013 Equity Incentive Plan, as amended.

**PART II**

**INFORMATION REQUIRED IN THE REGISTRATION STATEMENT** 

**Item 3.** **Incorporation of Documents by Reference.** 

The contents of the Registration Statements on Form S-8 previously filed with the Securities and Exchange Commission (the "Commission") on [February 4, 2014 (File No. 333-193735)](https://www.sec.gov/Archives/edgar/data/1429560/000110465914006232/a14-4875_1s8.htm), [May 14, 2014 (File No. 333-195957)](https://www.sec.gov/Archives/edgar/data/1429560/000110465914038721/a14-12226_3s8.htm), [January 23, 2015 (File No. 333-201672)](https://www.sec.gov/Archives/edgar/data/1429560/000110465915004180/a15-2867_1s8.htm), [January 11, 2016 (File No. 333-208948)](https://www.sec.gov/Archives/edgar/data/1429560/000110465916089127/a16-1526_1s8.htm), [January 4, 2017 (File No. 333-215421)](https://www.sec.gov/Archives/edgar/data/1429560/000110465917000566/a17-1205_3s8.htm), [January 8, 2018 (File No. 333-222471)](https://www.sec.gov/Archives/edgar/data/1429560/000110465918001285/a18-2367_1s8.htm), [January 8, 2019 (File No. 333-229161)](https://www.sec.gov/Archives/edgar/data/1429560/000110465919001254/a19-2013_1s8.htm), [January 16, 2020 (File No. 333-235942)](https://www.sec.gov/Archives/edgar/data/1429560/000110465920004740/tm203621d1_s8.htm), [January 22, 2021 (File No. 333-252350)](https://www.sec.gov/Archives/edgar/data/1429560/000110465921006696/tm213157d1_s8.htm) and [January 27, 2022 (File No. 333-262377)](https://www.sec.gov/Archives/edgar/data/1429560/000110465922008331/tm224145d1_s8.htm) are incorporated by reference herein.

**Item 8.** **Exhibits.** 

---

| | |
|:---|:---|
| **Exhibit<br> Number** | **Exhibit Description** |
| [4.1](http://www.sec.gov/Archives/edgar/data/1429560/000110465914006703/a14-5066_1ex3d1.htm) | [Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K, filed with the Commission on February 5, 2014).](http://www.sec.gov/Archives/edgar/data/1429560/000110465914006703/a14-5066_1ex3d1.htm) |
| [4.2](http://www.sec.gov/Archives/edgar/data/1429560/000110465918034792/a18-13855_1ex3d1.htm) | [Certificate of Amendment of Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to Registrant's Current Report on Form 8-K, filed with the Commission on May 21, 2018).](http://www.sec.gov/Archives/edgar/data/1429560/000110465918034792/a18-13855_1ex3d1.htm) |
| [4.3](https://www.sec.gov/Archives/edgar/data/1429560/000110465922116467/tm2230094d3_ex3-1.htm) | [Certificate of Amendment of Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to Registrant's Current Report on Form 8-K, filed with the Commission on November 9, 2022).](https://www.sec.gov/Archives/edgar/data/1429560/000110465922116467/tm2230094d3_ex3-1.htm) |
| [4](http://www.sec.gov/Archives/edgar/data/1429560/000110465914006703/a14-5066_1ex3d2.htm)<u>.4</u> | [Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.2 to the Registrant's Current Report on Form 8-K, filed with the Commission on February 5, 2014).](http://www.sec.gov/Archives/edgar/data/1429560/000110465914006703/a14-5066_1ex3d2.htm) |
| <u>4.5</u> | [Specimen stock certificate evidencing shares of Common Stock of the Registrant (incorporated by reference to Exhibit 4.2 to the Registrant's Registration Statement on Form S-1, as amended (File No. 333-191643), originally filed with the Commission on October 9, 2013).](http://www.sec.gov/Archives/edgar/data/1429560/000104746913010474/a2217334zex-4_2.htm) |
| <u>4.6</u> | [2013 Equity Incentive Plan, as amended (incorporated by reference to Exhibit 99.1 to the Registrant's Registration Statement on Form S-8, filed with the Commission on May 14, 2014).](http://www.sec.gov/Archives/edgar/data/1429560/000110465914038721/a14-12226_3ex99d1.htm) |
| <u>4.7</u> | [Form of Stock Option Grant Notice and Stock Option Agreement under 2013 Equity Incentive Plan (incorporated by reference to Exhibit 10.5 to Registrant's Quarterly Report on Form 10-Q, filed with the SEC on May 7, 2015).](http://www.sec.gov/Archives/edgar/data/1429560/000110465915035497/a15-7924_1ex10d5.htm) |
| [4.8](http://www.sec.gov/Archives/edgar/data/1429560/000104746913010012/a2217124zex-10_13.htm) | [Form of Restricted Stock Grant Notice and Restricted Stock Unit Award Agreement under 2013 Equity Incentive Plan (incorporated by reference to Exhibit 10.13 to the Registrant's Registration Statement on Form S-1, as amended (File No. 333-191643), filed with the SEC on October 9, 2013).](http://www.sec.gov/Archives/edgar/data/1429560/000104746913010012/a2217124zex-10_13.htm) |
| [5.1#](tm234304d1_ex5-1.htm) | [<u>Opinion of Troutman Pepper Hamilton Sanders LLP.</u>](tm234304d1_ex5-1.htm) |
| [23.1#](tm2229091d1_ex23-1.htm) | [Consent of Independent Registered Public Accounting Firm.](tm2229091d1_ex23-1.htm) |
| [23.2#](tm234304d1_ex5-1.htm) | [<u>Consent of Troutman Pepper Hamilton Sanders LLP (included in Exhibit 5.1).</u>](tm234304d1_ex5-1.htm) |
| [24.1#](#a_001) | [Power of Attorney (included on the signature page of this Form S-8).](#a_001) |
| [107#](tm234304d1_ex-filingfees.htm) | [<u>Filing Fee Table.</u>](tm234304d1_ex-filingfees.htm) |

---

# Filed herewith.

**Item 9.** **Undertakings.** 

1. The undersigned
 registrant hereby undertakes:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**(a)** To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**(i)** To include any prospectus required by Section 10(a)(3) of the Securities Act.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**(ii)** To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20% change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective registration statement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**(iii)** To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement;

*provided, however*, that paragraphs (a)(i) and (a)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the registrant pursuant to section 13 or section 15(d) of the Exchange Act that are incorporated by reference in the registration statement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**(b)** That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered herein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**(c)** To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

2. The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan's annual report pursuant to section 15(d) of the Exchange Act) that is incorporated by reference in the Registration Statement shall be deemed to be a new registration statement relating to the securities offered herein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

3. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.

**SIGNATURES**

Pursuant to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Chesterbrook, Commonwealth of Pennsylvania, on January 24, 2023.

---

| | |
|:---|:---|
| **TREVENA, INC.** | **TREVENA, INC.** |
| By: | /s/ Barry Shin |
|  | Barry Shin |
|  | Chief Financial Officer |

---

**POWER OF ATTORNEY**

**KNOW ALL PERSONS BY THESE PRESENTS,** that each person whose signature appears below constitutes and appoints **CARRIE L. BOURDOW** and **BARRY SHIN**, and each or any one of them, his true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or their or his substitutes or substitute, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

---

| | | |
|:---|:---|:---|
| **Signature** | **Title** | **Date** |
| /s/ Carrie L. Bourdow | President, Chief Executive Officer and Director | January 24, 2023 |
| Carrie L. Bourdow | (*Principal Executive Officer)* |  |
| /s/ Barry Shin | Chief Financial Officer | January 24, 2023 |
| Barry Shin | *(Principal Financial and Accounting Officer)* |  |
| /s/ Leon O. Moulder, Jr. | Chairman of the Board of Directors | January 24, 2023 |
| Leon O. Moulder, Jr. |  |  |
| /s/ Scott Braunstein | Director | January 24, 2023 |
| Scott Braunstein, M.D. |  |  |
| /s/ Michael R. Dougherty | Director | January 24, 2023 |
| Michael R. Dougherty |  |  |
| /s/ Marvin H. Johnson, Jr. | Director | January 24, 2023 |
| Marvin H. Johnson, Jr. |  |  |
| /s/ Jake R. Nunn | Director | January 24, 2023 |
| Jake R. Nunn |  |  |
| /s/ Anne M. Phillips, M.D. | Director | January 24, 2023 |
| Anne M. Phillips, M.D. |  |  |
| /s/ Barbara Yanni | Director | January 24, 2023 |
| Barbara Yanni |  |  |

---

## Exhibit 5.1

**Exhibit 5.1**

---

| | |
|:---|:---|
| Troutman Pepper Hamilton Sanders LLP | ![](tm234304d1_ex5-1img001.jpg) |
| 3000 Two Logan Square, Eighteenth and Arch Streets | ![](tm234304d1_ex5-1img001.jpg) |
| Philadelphia, PA 19103-2799 | ![](tm234304d1_ex5-1img001.jpg) |
|  | ![](tm234304d1_ex5-1img001.jpg) |
| troutman.com | ![](tm234304d1_ex5-1img001.jpg) |

---

January 24, 2023

Trevena, Inc.

955 Chesterbook Blvd., Suite 110

Chesterbook, Pennsylvania 19087

---

| | |
|:---|:---|
| **RE:** | **Registration Statement on Form S-8** |

---

Ladies and Gentlemen:

We have acted as counsel to Trevena, Inc., a Delaware corporation (the "Company"), in connection with the Registration Statement on Form S-8 (the "Registration Statement"), as filed by the Company with the Securities and Exchange Commission (the "Commission") on the date hereof, pursuant to the Securities Act of 1933, as amended (the "Securities Act"), to register 309,363 shares of common stock, par value $0.001 per share, of the Company (the "Shares"), issuable by the Company from time to time pursuant to the Company's 2013 Equity Incentive Plan, as amended (the "Plan").

This opinion is being furnished in accordance with the requirements of Item 8(a) of Form S-8 and Item 601(b)(5)(i) of Regulation S-K. No opinion is expressed herein as to any matter pertaining to the contents of the Registration Statement or the related prospectuses, other than as expressly stated herein with respect to the issuance of the Shares.

We have examined originals or copies of such corporate records, agreements and instruments of the Company, statements and certificates of public officials and officers of the Company, and such other documents, records and instruments, including the Plan, and we have made such legal and factual inquiries as we have deemed necessary or appropriate as a basis for us to render the opinions hereinafter expressed. In our examination of the foregoing, we have assumed the genuineness of all signatures, the legal competence and capacity of natural persons, the accuracy and completeness of all documents submitted to us, the authenticity of documents submitted to us as originals and the conformity with authentic original documents of all documents submitted to us as copies. As to all matters of fact, we have relied on the representations and statements of fact made in the documents so reviewed, and we have not independently established the facts so relied on.

In connection herewith, we have assumed that (i) all of the documents referred to in this opinion letter have been duly authorized by, have been duly executed and delivered by, and constitute the valid, binding and enforceable obligations of, all of the parties to such documents, (ii) all of the signatories to the documents referred to in this opinion letter have been duly authorized, and (iii) all of the parties to the documents referred to in this opinion letter are duly organized and validly existing and have the power and authority (corporate or other) to execute, deliver and perform such documents.

---

| | |
|:---|:---|
| January 24, 2023<br> Page 2 | ![](tm234304d1_ex5-1img001.jpg) |

---

We do not purport to express an opinion on any laws other than the laws of the State of Delaware. The opinions set forth herein are made as of the date hereof and are subject to, and may be limited by, future changes in the factual matters set forth herein, and we undertake no duty to advise you of the same. The opinions expressed herein are based upon the law in effect (and published or otherwise generally available) on the date hereof, and we assume no obligation to revise or supplement these opinions should such law be changed by legislative action, judicial decision or otherwise. In rendering our opinions, we have not considered, and hereby disclaim any opinion as to, the application or impact of any laws, cases, decisions, rules or regulations of any other jurisdiction, court or administrative agency.

Subject to the foregoing and the other matters set forth herein, it is our opinion that, as of the date hereof, when the Shares shall have been duly registered on the books of the transfer agent and registrar therefor in the name or on behalf of the purchasers and have been issued and sold by the Company as contemplated by the Plan, assuming in each case that the individual issuances, grants or awards under the Plan are duly authorized by all necessary corporate action and duly issued, granted or awarded and exercised in accordance with the requirements of law and the applicable Plan (and the agreements and awards duly adopted thereunder and in accordance therewith), the Shares will be legally and validly issued, fully paid and nonassessable.

We do not render any opinions except as set forth above. We hereby consent to the filing of this opinion as Exhibit 5.1 to the Registration Statement. We also consent to your filing copies of this opinion as an exhibit to the Registration Statement with such agencies of such states as you deem necessary in the course of complying with the laws of such states regarding the offering and sale of the securities addressed herein. In giving this consent, we do not admit that we are within the category of persons whose consent is required by Section 7 of the Securities Act or the rules and regulations promulgated thereunder by the Commission.

---

| |
|:---|
| Very truly yours, |
| /s/ Troutman Pepper Hamilton Sanders LLP |
| Troutman Pepper Hamilton Sanders LLP |

---

## Exhibit 23.1

**Exhibit 23.1**

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the Registration Statement (Form S-8) pertaining to the 2013 Equity Incentive Plan of Trevena, Inc. of our report dated March 31, 2022, with respect to the financial statements of Trevena, Inc. included in its Annual Report (Form 10-K) for the year ended December 31, 2021, filed with the Securities and Exchange Commission.

---

| | |
|:---|:---|
|  | ![](tm2229091d1_ex23-1img001.jpg) |
| Philadelphia, Pennsylvania |  |
| January 24, 2023 |  |

---

## Ex-Filing

**Exhibit 107**

**Calculation of Filing Fee Tables**

**Form S-8**

(Form Type)

**Trevena, Inc.**

(Exact Name of Registrant as Specified in its Charter)

**<u>Table 1: Newly Registered Securities</u>**

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| **Security Type** | **Security <br> Class Title** | **Fee <br> Calculation <br> Rule** | **Amount<br> Registered (1)** | **Proposed<br> Maximum<br> Offering <br> Price Per<br> Unit (2)** | **Maximum<br> Aggregate<br> Offering <br> Price** | **Fee Rate** | **Amount of<br> Registration <br> Fee** |
| Equity | Common Stock | Rules 457(c) and 457(h) | 309363 (3) | $1.88 | $581138 | 0.0001102 | $64.04 |
| **Total Offering Amounts** | **Total Offering Amounts** | **Total Offering Amounts** | **Total Offering Amounts** | - | $581138 | - | $64.04 |
| **Total Fee Offsets** | **Total Fee Offsets** | **Total Fee Offsets** | **Total Fee Offsets** | - | - | - | - |
| **Net Fee Due** | **Net Fee Due** | **Net Fee Due** | **Net Fee Due** | - | - | - | $64.04 |

---

(1) Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "Securities Act"), this registration statement also covers an indeterminate number of additional shares which may be offered and issued to prevent dilution resulting from stock splits, stock dividends or similar transactions.

(2) Estimated solely for the purpose of calculating the registration fee in accordance with Rules 457(c) and 457(h) of the Securities Act. The amount of the registration fee is based on a price of $1.88 per share of Common Stock, which is the average of the high and low prices of the registrant's Common Stock as reported by the NASDAQ Capital Market on January 20, 2023.

(3) Represents 309,363 shares of Common Stock issuable under the Trevena, Inc. 2013 Equity Incentive Plan (as amended, the "2013 Plan"). The registrant previously registered (i) 3,537,703 shares of Common Stock issuable under the 2013 Plan on a Form S-8 filed on February 4, 2014 (Reg. No. 333-193735), (ii) 1,050,000 shares of Common Stock issuable under the 2013 Plan on a Form S-8 filed on May 14, 2014 (Reg. No. 333-195957), (iii) 1,569,646 shares of Common Stock issuable under the 2013 Plan on a Form S-8 filed on January 23, 2015 (Reg. No. 333-201672), (iv) 2,032,104 shares of Common Stock issuable under the 2013 Plan on a Form S-8 filed on January 11, 2016 (Reg. No. 333-208948), (v) 2,230,736 shares of Common Stock issuable under the 2013 Plan on a Form S-8 filed on January 4, 2017 (Reg. No. 333-215421), (vi) 2,492,431 shares of Common Stock issuable under the 2013 Plan on a Form S-8 filed on January 8, 2018 (Reg. No. 333-222471), (vii) 3,292,936 shares of Common Stock issuable under the 2013 Plan on a Form S-8 filed on January 8, 2019 (Reg. No. 333-229161), (viii) 3,768,550 shares of Common Stock issuable under the 2013 Plan on a Form S-8 filed on January 16, 2020 (Reg. No. 333-235942), (ix) 6,399,997 shares of Common Stock issuable under the 2013 Plan on a Form S-8 filed on January 22, 2021 (Reg. No. 333-252350), and (x) 6,620,800 shares of Common Stock issuable under the 2013 Plan on a Form S-8 filed on January 27, 2022 (Reg. No. 333-262377).