# EDGAR Filing Document

**Accession Number:** 0001447028
**File Stem:** 0001171843-26-001838
**Filing Date:** 2026-3
**Character Count:** 23187
**Document Hash:** df9433e1995870da52b1ef573bcc9fdf
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001171843-26-001838.hdr.sgml**: 20260323

**ACCESSION NUMBER**: 0001171843-26-001838

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 13

**CONFORMED PERIOD OF REPORT**: 20260323

**ITEM INFORMATION**: Results of Operations and Financial Condition

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20260323

**DATE AS OF CHANGE**: 20260323

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Arbutus Biopharma Corp
- **CENTRAL INDEX KEY:** 0001447028
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 980597776
- **STATE OF INCORPORATION:** A1
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-34949
- **FILM NUMBER:** 26779901

**BUSINESS ADDRESS:**
- **STREET 1:** 701 VETERANS CIRCLE
- **CITY:** WARMINSTER
- **STATE:** PA
- **ZIP:** 18974
- **BUSINESS PHONE:** 604-419-3200

**MAIL ADDRESS:**
- **STREET 1:** 701 VETERANS CIRCLE
- **CITY:** WARMINSTER
- **STATE:** PA
- **ZIP:** 18974

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** TEKMIRA PHARMACEUTICALS Corp
- **DATE OF NAME CHANGE:** 20110607

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** TEKMIRA PHARMACEUTICALS CORP
- **DATE OF NAME CHANGE:** 20081003

?xml version='1.0' encoding='ASCII'? Form 8-K

### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION

### Washington, D.C. 20549
_________________

### FORM 8-K
_________________

#### CURRENT REPORT

#### Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

#### Date of Report (Date of earliest event reported): March 23, 2026
_______________________________

#### Arbutus Biopharma Corporation
(Exact name of registrant as specified in its charter)

_______________________________

---

| | | |
|:---|:---|:---|
| **British Columbia, Canada** | **001-34949** | **98-0597776** |
| (State or Other Jurisdiction of Incorporation) | (Commission File Number) | (I.R.S. Employer Identification No.) |

---

#### 701 Veterans Circle

#### Warminster, Pennsylvania 18974
(Address of Principal Executive Offices) (Zip Code)

(267) 469-0914

(Registrant's telephone number, including area code)

(Former name or former address, if changed since last report)

_______________________________

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

---

| | | |
|:---|:---|:---|
| Title of each class | Trading Symbol(s) | Name of each exchange on which registered |
| Common Shares, without par value | ABUS | The Nasdaq Stock Market LLC |

---

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

**Item 2.02. Results of Operations and Financial Condition.**

On March 23, 2026, Arbutus Biopharma Corporation issued a press release announcing its financial results for the fourth quarter and year ended December 31, 2025 and certain other information. A copy of the press release is furnished herewith as Exhibit 99.1 hereto and is incorporated by reference herein.

**Item 9.01. Financial Statements and Exhibits.**

**(d) Exhibits.**

---

| | |
|:---|:---|
| **<u>Exhibit Number</u>** | **<u>Description</u>** |
| [99.1](exh_991.htm) | [Press Release dated March 23, 2026](exh_991.htm) |
| 104 | Cover Page Interactive Data File (embedded within the Inline XBRL document) |

---

#### SIGNATURE
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

---

| | | |
|:---|:---|:---|
|  | **Arbutus Biopharma Corporation** | **Arbutus Biopharma Corporation** |
| Date: March 23, 2026 | By: | <u>/s/ Tuan Nguyen&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u> |
|  |  | Tuan Nguyen |
|  |  | Chief Financial Officer |

---

## Exhibit 99.1

**EXHIBIT 99.1**

**Arbutus Reports Fourth Quarter and Year End 2025 Financial Results and Provides Corporate Update**

**Strong financial position with cash, cash equivalents and marketable securities of $91.5M as of December 2025**

**$2.25B Moderna global settlement for infringement of lipid nanoparticle (LNP) delivery technology represents significant outcome for Arbutus and Genevant**

**Two additional patients from Phase 2a clinical trials of imdusiran achieve functional cure**

**Milestone payment received under Alnylam LNP license for product candidate to treat hepatocellular carcinoma (HCC)**

WARMINSTER, Pa., March 23, 2026 (GLOBE NEWSWIRE) -- Arbutus Biopharma Corporation (Nasdaq: ABUS) ("Arbutus" or the "Company"), a clinical-stage biopharmaceutical company focused on infectious disease, today reported fourth quarter and year end 2025 financial results and provided a corporate update.

"We delivered another strong quarter, maintaining a disciplined approach to capital allocation and a continued focus on maximizing our cash runway," said Lindsay Androski, President and CEO of Arbutus. "I am thrilled to announce that two additional patients from our Phase 2a trials of imdusiran have achieved functional cure in chronic hepatitis B ("cHBV"), and am pleased with our team's continuing progress on our cHBV programs."

**<u>LNP Litigation</u>**

* On March 3, 2026, Arbutus, along with its exclusive licensee, Genevant Sciences ("Genevant"), entered into a settlement agreement to resolve all global patent infringement litigation and patent revocation proceedings involving Moderna. As part of the settlement, Moderna will pay Arbutus and Genevant $950 million upfront in July 2026 ("Noncontingent Settlement Payment") and an additional $1.3 billion contingent upon an appellate ruling that 28 U.S.C. §1498 ("Section 1498") does not bar Arbutus' and Genevant's claims against Moderna for patent infringement, except as to doses characterized by the district court as having gone to U.S. government employees. In asserting that defense, Moderna argued that Section 1498 applies such that U.S. taxpayers should assume liability for its infringement of Arbutus' and Genevant's patents for sales made under one of its government contracts. Moderna has also consented to entry of a judgment of infringement and of no invalidity of four Arbutus/Genevant patents. For more information about the terms and conditions of the settlement with Moderna, including the contingent payment, please refer to Arbutus' Annual Report on Form 10-K filed with the SEC on March 20, 2026. Under the Company's license with Genevant, the Company is entitled to receive, after deduction of litigation costs, 20% of the Noncontingent Settlement Payment. In addition, the Company owns approximately 16% of the outstanding common equity of Genevant.

* Arbutus continues to consult closely with and support Genevant to protect and defend Arbutus' intellectual property, which is the subject of an on-going lawsuit against Pfizer/BioNTech. The Company, together with Genevant, is seeking fair compensation for use of Arbutus' patented lipid nanoparticle ("LNP") technology that was developed with great effort and at a great expense, and without which Pfizer/BioNTech's COVID-19 vaccines would not have been successful. The claim construction hearing for the lawsuit against Pfizer/BioNTech occurred in December 2024, and the court issued a claim construction ruling in September 2025, which construed the disputed claim terms in a manner the Company generally considers to be favorable. The parties are awaiting further scheduling in the litigation.

**<u>Corporate Updates</u>**

* Two additional patients from the Company's Phase 2a clinical trials of imdusiran achieved functional cure, making a total of 10 patients to date that have achieved functional cure during Phase 2a clinical trials and long-term follow-up. Two of these functionally cured patients seroreverted during long-term follow-up, but remain virally suppressed and off nucleos(t)ide analogue ("NA") therapy.

* In December 2025, the Company recognized revenue of $0.5 million following the achievement of a contractual milestone related to Alnylam's use of the Company's proprietary LNP technology in an additional product candidate to treat hepatocellular carcinoma (HCC), underscoring the important role the Company's LNP technology plays in the delivery of nucleic acids to the body. Payment was received in January 2026.

* In connection with payments the Company expects to receive under the Moderna settlement, the Company is currently evaluating a return of capital to its shareholders in the third quarter of calendar year 2026, following the receipt of its portion of the noncontingent lump sum payment from Moderna.

**<u>Financial Results</u>**

**Cash, Cash Equivalents and Investments** 

As of December 31, 2025, the Company had cash, cash equivalents and investments in marketable securities of $91.5 million compared to $122.6 million as of December 31, 2024. During the year ended December 31, 2025, the Company used $39.6 million in operating activities, which included one-time payments related to its restructuring efforts. This was partially offset by $5.5 million of proceeds from the exercise of stock options.

**Revenue** 

Total revenue was $14.1 million for the year ended December 31, 2025, compared to $6.2 million for the same period in 2024. The increase of $7.9 million was due to the recognition of all previously-deferred revenue as a result of the conclusion of the Company's strategic partnership with Qilu Pharmaceutical, partially offset by a decrease in license royalty revenues due to a decline in Alnylam's sales of ONPATTRO.

**Operating Expenses** 

Research and development expenses were $25.2 million for the year ended December 31, 2025, compared to $54.0 million for the same period in 2024. The decrease of $28.8 million was due primarily to cost savings from the Company's decisions to streamline the organization to focus its efforts on advancing the clinical development of imdusiran and AB-101, which included ceasing all discovery efforts, discontinuing its IM-PROVE III clinical trial, and right-sizing the Company's workforce.

General and administrative expenses were $15.9 million for the year ended December 31, 2025, compared to $22.1 million for the same period in 2024. This decrease was due primarily to cost-cutting efforts by the Company, which drove reductions in employee compensation-related expenses and legal fees.

Restructuring costs for the year ended December 31, 2025 were $12.9 million, and all remaining restructuring-related payments are expected to be made by the first quarter of 2026.

**Net Loss**

For the year ended December 31, 2025, the Company's net loss was $33.5 million, or a loss of $0.17 per basic and diluted common share, as compared to a net loss of $69.9 million, or a loss of $0.38 per basic and diluted common share, for the quarter ended December 31, 2024.

**Outstanding Shares** 

As of December 31, 2025, the Company had 192.5 million common shares issued and outstanding, as well as 14.0 million stock options and unvested restricted stock units outstanding.

---

| | | |
|:---|:---|:---|
| **UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF INCOME AND LOSS**<br>**(in thousands, except share and per share data)** | **UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF INCOME AND LOSS**<br>**(in thousands, except share and per share data)** | **UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF INCOME AND LOSS**<br>**(in thousands, except share and per share data)** |
|  | **Year ended December 31,** | **Year ended December 31,** |
|  | **2025** | **2024** |
| **Revenue** |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Collaborations and licenses | $12601 | $3919 |
| &nbsp;&nbsp;&nbsp;&nbsp;Non-cash royalty revenue | 1482 | 2252 |
| **Total revenue** | 14083 | 6171 |
| **Operating expenses** |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Research and development | 25241 | 54037 |
| &nbsp;&nbsp;&nbsp;&nbsp;General and administrative | 15893 | 22108 |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in fair value of contingent consideration | (1830) | 2625 |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring costs | 12939 | 3720 |
| **Total operating expenses** | 52243 | 82490 |
| **Loss from operations** | (38160) | (76319) |
| **Other income** |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Interest income | 4068 | 6585 |
| &nbsp;&nbsp;&nbsp;&nbsp;Gain on sale of property and equipment | 674 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Interest expense | (97) | (137) |
| &nbsp;&nbsp;&nbsp;&nbsp;Foreign exchange gain / (loss) | 14 | (49) |
| **Total other income** | 4659 | 6399 |
| **Net loss** | $(33501) | $(69920) |
| **Net loss per common share** |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Basic and diluted | $(0.17) | $(0.38) |
| **Weighted average number of common shares** |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Basic and diluted | 191599600 | 185608874 |

---

---

| | | |
|:---|:---|:---|
| **UNAUDITED CONDENSED CONSOLIDATED BALANCE SHEETS**<br>**(in thousands)** | **UNAUDITED CONDENSED CONSOLIDATED BALANCE SHEETS**<br>**(in thousands)** | **UNAUDITED CONDENSED CONSOLIDATED BALANCE SHEETS**<br>**(in thousands)** |
|  | **December 31, 2025** | **December 31, 2024** |
| Cash, cash equivalents and marketable securities, current | $91471 | $122623 |
| Accounts receivable and other current assets | 2985 | 4693 |
| &nbsp;&nbsp;&nbsp;&nbsp;**Total current assets** | 94456 | 127316 |
| Property and equipment, net of accumulated depreciation and impairment | 32 | 3309 |
| Right of use asset |  | 1048 |
| Other non-current assets | 130 | 34 |
| &nbsp;&nbsp;&nbsp;&nbsp;**Total assets** | $94618 | $131707 |
| Accounts payable and accrued liabilities | $5459 | $7564 |
| Deferred license revenue, current |  | 7571 |
| Lease liability, current | 547 | 483 |
| &nbsp;&nbsp;&nbsp;&nbsp;**Total current liabilities** | 6006 | 15618 |
| Liability related to sale of future royalties | 3442 | 4829 |
| Deferred license revenue, non-current |  | 2863 |
| Contingent consideration | 8395 | 10225 |
| Lease liability, non-current | 199 | 806 |
| Total stockholders' equity | 76576 | 97366 |
| &nbsp;&nbsp;&nbsp;&nbsp;**Total liabilities and stockholders' equity** | $94618 | $131707 |

---

---

| | | |
|:---|:---|:---|
| **UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS**<br>**(in thousands)** | **UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS**<br>**(in thousands)** | **UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS**<br>**(in thousands)** |
|  | **Year ended December 31,** | **Year ended December 31,** |
|  | **2025** | **2024** |
| Net loss | $(33501) | $(69920) |
| Non-cash items | 3887 | 7899 |
| Change in deferred license revenue | (10434) | (1357) |
| Other changes in working capital | 411 | (1472) |
| &nbsp;&nbsp;&nbsp;&nbsp;**Net cash used in operating activities** | (39637) | (64850) |
| &nbsp;&nbsp;&nbsp;&nbsp;**Net cash provided by investing activities** | 15580 | 22948 |
| Issuance of common shares pursuant to the Open Market Sale Agreement |  | 44123 |
| Cash provided by other financing activities | 5721 | 7873 |
| &nbsp;&nbsp;&nbsp;&nbsp;**Net cash provided by financing activities** | 5721 | 51996 |
| Effect of foreign exchange rate changes on cash and cash equivalents | 14 | (49) |
| &nbsp;&nbsp;&nbsp;&nbsp;**(Decrease) / increase in cash and cash equivalents** | (18322) | 10045 |
| Cash and cash equivalents, beginning of period | 36330 | 26285 |
| &nbsp;&nbsp;&nbsp;&nbsp;**Cash and cash equivalents, end of period** | 18008 | 36330 |
| Investments in marketable securities | 73463 | 86293 |
| &nbsp;&nbsp;&nbsp;&nbsp;**Cash, cash equivalents and investments, end of period** | $91471 | $122623 |

---

**<u>About Imdusiran (AB-729)</u>**

Imdusiran is an RNAi therapeutic specifically designed to reduce all hepatitis B viral proteins and antigens, including hepatitis B surface antigen ("HBsAg"), which is thought to be a key prerequisite to enable reawakening of a patient's immune system to control the virus. Imdusiran targets hepatocytes using Arbutus' novel covalently conjugated *N*-Acetylgalactosamine ("GalNAc") delivery technology enabling subcutaneous delivery. In Arbutus' Phase 2a clinical trials, eight patients with cHBV achieved functional cure following treatment with imdusiran and NA therapy in combination with either pegylated interferon alfa-2a or low dose nivolumab plus an immunotherapeutic, with six out of the eight patients continuing to sustain functional cure for over two years. An additional 41 patients across the Company's Phase 2a clinical trials were able to remain off NA therapy for at least 48 weeks during their Phase 2a clinical trials following treatment with imdusiran. Two additional patients who discontinued NA therapy in their Phase 2a clinical trials have now achieved functional cure during their participation in long-term follow-up. Functional cure is defined as sustained HBsAg seroclearance and hepatitis B virus deoxyribonucleic acid ("HBV DNA") less than the lower limit of quantification after 24 weeks off treatment, with or without anti-hepatitis B surface antibodies. Clinical data generated thus far has shown imdusiran to be generally safe and well-tolerated, while also providing meaningful reductions in HBsAg and HBV DNA.

**<u>About HBV</u>**

Hepatitis B is a potentially life-threatening liver infection caused by hepatitis B virus ("HBV"). HBV can cause chronic infection which leads to a higher risk of death from cirrhosis and liver cancer. cHBV infection represents a significant unmet medical need. The World Health Organization estimates that over 250 million people worldwide suffer from cHBV infection, while other estimates indicate that approximately 2 million people in the United States suffer from cHBV infection. Approximately 1.1 million people die every year from complications related to cHBV infection despite the availability of effective vaccines and current treatment options.

**<u>About Arbutus</u>**

Arbutus Biopharma Corporation (Nasdaq: ABUS) is a clinical-stage biopharmaceutical company focused on infectious disease. The Company is currently developing imdusiran (AB-729) and an oral PD-L1 inhibitor (AB-101) for the treatment of cHBV infection. The Company is also consulting closely with and supporting its exclusive licensee, Genevant Sciences, to protect and defend its intellectual property, which is the subject of on-going lawsuits against Moderna and Pfizer/BioNTech for use of Arbutus' patented LNP technology in their COVID-19 vaccines. For more information, visit www.arbutusbio.com.

**<u>Forward-Looking Statements and Information</u>**

This press release contains forward-looking statements within the meaning of the Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, and forward-looking information within the meaning of Canadian securities laws (collectively, forward-looking statements). Forward-looking statements in this press release include statements about: the potential to lead to a functional cure for HBV and/or the discontinuation of HBV therapies after treatment with Arbutus' product candidates; the durability of clinical benefits from Arbutus' product candidates; the potential for Arbutus' product candidates to achieve success in clinical trials; Arbutus' pipeline and development plans for its cHBV programs; Arbutus' plans with respect to ongoing patent litigation matters, including the expected timing thereof and the settlement of the Moderna litigation; and Arbutus' evaluation of a potential return of capital to its shareholders.

With respect to the forward-looking statements contained in this press release, Arbutus has made numerous assumptions regarding, among other things: the effectiveness and timeliness of clinical trials, and the usefulness of the data; the continued demand for Arbutus' assets; and the stability of economic and market conditions. While Arbutus considers these assumptions to be reasonable, these assumptions are inherently subject to significant business, economic, competitive, market and social uncertainties and contingencies. Additionally, there are known and unknown risk factors which could cause Arbutus' actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements contained herein. Known risk factors include, among others: ongoing and anticipated clinical trials may be more costly or take longer to complete than anticipated, and may never be initiated or completed, or may not generate results that warrant future development of the tested product candidate; Arbutus may elect to change its strategy regarding its product candidates and clinical development activities; Arbutus may not receive the necessary regulatory approvals for the clinical development of Arbutus' product candidates; uncertainties associated with litigation generally and patent litigation specifically; economic and market conditions may worsen; market shifts may require a change in strategic focus; Arbutus' workforce reduction and plans to reduce its net cash burn may not materially extend the cash runway and may create a distraction or uncertainty that may adversely affect its operating results, business, or investor perceptions; and risks related to the sufficiency of Arbutus' cash resources for its foreseeable and unforeseeable operating expenses and capital expenditures.

A more complete discussion of the risks and uncertainties facing Arbutus appears in Arbutus' Annual Report on Form 10-K, Arbutus' Quarterly Reports on Form 10-Q and Arbutus' continuous and periodic disclosure filings, which are available at www.sedar.com and at www.sec.gov. All forward-looking statements herein are qualified in their entirety by this cautionary statement, and Arbutus disclaims any obligation to revise or update any such forward-looking statements or to publicly announce the result of any revisions to any of the forward-looking statements contained herein to reflect future results, events or developments, except as required by law.

Arbutus Biopharma Corporation / ir@arbutusbio.com