# EDGAR Filing Document

**Accession Number:** 0001791827
**File Stem:** 0001791827-25-000007
**Filing Date:** 2025-8
**Character Count:** 9463
**Document Hash:** 5baaa3336a4a0619f6faa7cb07cd9765
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001791827-25-000007.hdr.sgml**: 20250814

**ACCESSION NUMBER**: 0001791827-25-000007

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20250630

**FILED AS OF DATE**: 20250814

**DATE AS OF CHANGE**: 20250814

**EFFECTIVENESS DATE**: 20250814

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Avidity Partners Management LP
- **CENTRAL INDEX KEY:** 0001791827

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-20028
- **FILM NUMBER:** 251216966

**BUSINESS ADDRESS:**
- **STREET 1:** 2828 N HARWOOD STREET
- **STREET 2:** SUITE 1220
- **CITY:** DALLAS
- **STATE:** TX
- **ZIP:** 75201
- **BUSINESS PHONE:** 214-550-1822

**MAIL ADDRESS:**
- **STREET 1:** 2828 N HARWOOD STREET
- **STREET 2:** SUITE 1220
- **CITY:** DALLAS
- **STATE:** TX
- **ZIP:** 75201

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 06-30-2025

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** Avidity Partners Management LP<br>**Address:** 2828 N HARWOOD STREET<br>SUITE 1220<br>DALLAS, TX 75201

**Form 13F File Number:** 028-20028

**CRD Number (if applicable):** 000304628

**SEC File Number (if applicable):** 801-118809

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Charles Hoedebeck<br>**Title:** Chief Financial Officer<br>**Phone:** 214.550.1696

**Signature, Place, and Date of Signing:**

/s/ Charles Hoedebeck  Dallas, TX  08-14-2025<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 56

**Form 13F Information Table Value Total:** $501976646

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| AKERO THERAPEUTICS INC | COM | 00973Y108 |  | 7150240 | 134000 | SH |  | SOLE |  | 134000 | 0 | 0 |
| ALTIMMUNE INC | COM NEW | 02155H200 |  | 406350 | 105000 | SH |  | SOLE |  | 105000 | 0 | 0 |
| APOGEE THERAPEUTICS INC | COM | 03770N101 |  | 2822950 | 65000 | SH |  | SOLE |  | 65000 | 0 | 0 |
| ARCUTIS BIOTHERAPEUTICS INC | COM | 03969K108 |  | 3757360 | 268000 | SH |  | SOLE |  | 268000 | 0 | 0 |
| ARS PHARMACEUTICALS INC | COM | 82835W108 |  | 2443000 | 140000 | SH |  | SOLE |  | 140000 | 0 | 0 |
| ARVINAS INC | COM | 04335A105 |  | 1789672 | 243162 | SH |  | SOLE |  | 243162 | 0 | 0 |
| AXSOME THERAPEUTICS INC | COM | 05464T104 |  | 9864855 | 94500 | SH |  | SOLE |  | 94500 | 0 | 0 |
| BEAM THERAPEUTICS INC | COM | 07373V105 |  | 6963894 | 409400 | SH |  | SOLE |  | 409400 | 0 | 0 |
| BOSTON SCIENTIFIC CORP | COM | 101137107 |  | 34564538 | 321800 | SH |  | SOLE |  | 321800 | 0 | 0 |
| BRIDGEBIO PHARMA INC | COM | 10806X102 |  | 6045200 | 140000 | SH |  | SOLE |  | 140000 | 0 | 0 |
| CARDINAL HEALTH INC | COM | 14149Y108 |  | 2520000 | 15000 | SH |  | SOLE |  | 15000 | 0 | 0 |
| CENCORA INC | COM | 03073E105 |  | 9835080 | 32800 | SH |  | SOLE |  | 32800 | 0 | 0 |
| CG ONCOLOGY INC | COM | 156944100 |  | 38998492 | 1499942 | SH |  | SOLE |  | 1499942 | 0 | 0 |
| CONTEXT THERAPEUTICS INC | COM | 21077P108 |  | 4899097 | 7477255 | SH |  | SOLE |  | 7477255 | 0 | 0 |
| DANAHER CORPORATION | COM | 235851102 |  | 17719338 | 89700 | SH |  | SOLE |  | 89700 | 0 | 0 |
| DEXCOM INC | COM | 252131107 |  | 18374545 | 210500 | SH |  | SOLE |  | 210500 | 0 | 0 |
| DIANTHUS THERAPEUTICS INC | COM | 252828108 |  | 32470264 | 1742902 | SH |  | SOLE |  | 1742902 | 0 | 0 |
| DOXIMITY INC | CL A | 26622P107 |  | 3680400 | 60000 | SH |  | SOLE |  | 60000 | 0 | 0 |
| ENCOMPASS HEALTH CORP | COM | 29261A100 |  | 9074620 | 74000 | SH |  | SOLE |  | 74000 | 0 | 0 |
| ENLIVEN THERAPEUTICS INC | COM | 29337E102 |  | 226678 | 11300 | SH |  | SOLE |  | 11300 | 0 | 0 |
| EXACT SCIENCES CORP | COM | 30063P105 |  | 18864700 | 355000 | SH |  | SOLE |  | 355000 | 0 | 0 |
| GENMAB A/S | SPONSORED ADS | 372303206 |  | 13429000 | 650000 | SH |  | SOLE |  | 650000 | 0 | 0 |
| HEALTHEQUITY INC | COM | 42226A107 |  | 9637920 | 92000 | SH |  | SOLE |  | 92000 | 0 | 0 |
| HINGE HEALTH INC | CL A | 433313103 |  | 16681302 | 322344 | SH |  | SOLE |  | 322344 | 0 | 0 |
| HUMANA INC | COM | 444859102 |  | 6747648 | 27600 | SH |  | SOLE |  | 27600 | 0 | 0 |
| IMMUNIC INC | COM | 4525EP101 |  | 3917028 | 5615811 | SH |  | SOLE |  | 5615811 | 0 | 0 |
| INSMED INC | COM PAR $.01 | 457669307 |  | 5937760 | 59000 | SH |  | SOLE |  | 59000 | 0 | 0 |
| INTELLIA THERAPEUTICS INC | COM | 45826J105 |  | 2176160 | 232000 | SH |  | SOLE |  | 232000 | 0 | 0 |
| INTUITIVE SURGIVAL INC | COM NEW | 46120E602 |  | 14726411 | 27100 | SH |  | SOLE |  | 27100 | 0 | 0 |
| JADE BIOSCIENCES INC | COM NEW | 008064206 |  | 11260588 | 1127186 | SH |  | SOLE |  | 1127186 | 0 | 0 |
| KARYOPHARM THERAPEUTICS INC | COM NEW | 48576U205 |  | 579979 | 134566 | SH |  | SOLE |  | 134566 | 0 | 0 |
| KEZAR LIFE SCIENCES INC | COM NEW | 49372L209 |  | 2301908 | 502600 | SH |  | SOLE |  | 502600 | 0 | 0 |
| MADRIGAL PHARMACEUTICALS INC | COM NEW | 558868105 |  | 5750160 | 19000 | SH |  | SOLE |  | 19000 | 0 | 0 |
| MCKESSON CORP | COM NEW | 58155Q103 |  | 9892530 | 13500 | SH |  | SOLE |  | 13500 | 0 | 0 |
| MOONLAKE IMMUNOTHERAPEUTICS | A ORD | 61559X104 |  | 1840800 | 39000 | SH |  | SOLE |  | 39000 | 0 | 0 |
| NATERA INC | COM | 632307104 |  | 33669742 | 199300 | SH |  | SOLE |  | 199300 | 0 | 0 |
| OMADA HEALTH INC | COM | 68170A108 |  | 7147980 | 390600 | SH |  | SOLE |  | 390600 | 0 | 0 |
| ORGANON  CO | COM | 68622V106 |  | 6195200 | 640000 | SH |  | SOLE |  | 640000 | 0 | 0 |
| ORUKA THERAPEUTICS INC | COM | 687604108 |  | 3947310 | 352124 | SH |  | SOLE |  | 352124 | 0 | 0 |
| PERSPECTIVE THERAPEUTICS INC | COM NEW | 46489V302 |  | 6393570 | 1858596 | SH |  | SOLE |  | 1858596 | 0 | 0 |
| PHATHOM PHARMACEUTICALS INC | COM | 71722W107 |  | 10208555 | 1064500 | SH |  | SOLE |  | 1064500 | 0 | 0 |
| REPLIGEN CORP | COM | 759916109 |  | 13246470 | 106500 | SH |  | SOLE |  | 106500 | 0 | 0 |
| REVIVA PHARMACEUTICALS HOLDING | COM | 76152G100 |  | 52592 | 138000 | SH |  | SOLE |  | 138000 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 8410194 | 228600 | SH |  | SOLE |  | 228600 | 0 | 0 |
| SCYNEXIS INC | COM NEW | 811292200 |  | 829268 | 1228910 | SH |  | SOLE |  | 1228910 | 0 | 0 |
| SOLENO THERAPEUTICS INC | COM | 834203309 |  | 2680960 | 32000 | SH |  | SOLE |  | 32000 | 0 | 0 |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 |  | 1404750 | 150000 | SH |  | SOLE |  | 150000 | 0 | 0 |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 |  | 3184100 | 340000 | SH | Call | SOLE |  | 340000 | 0 | 0 |
| TENET HEALTHCARE CORP | COM NEW | 88033G407 |  | 18656000 | 106000 | SH |  | SOLE |  | 106000 | 0 | 0 |
| TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADS | 881624209 |  | 11556020 | 689500 | SH |  | SOLE |  | 689500 | 0 | 0 |
| THERMO FISHER SCIENTIFIC INC | COM | 883556102 |  | 12001616 | 29600 | SH |  | SOLE |  | 29600 | 0 | 0 |
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 |  | 5599440 | 154000 | SH |  | SOLE |  | 154000 | 0 | 0 |
| UNIQURE NV | SHS | N90064101 |  | 2885580 | 207000 | SH |  | SOLE |  | 207000 | 0 | 0 |
| UNITEDHEALTH GROUP INC | COM | 91324P102 |  | 9983040 | 32000 | SH |  | SOLE |  | 32000 | 0 | 0 |
| VERONA PHARMA PLC | SPONSORED ADS | 925050106 |  | 3196804 | 33800 | SH |  | SOLE |  | 33800 | 0 | 0 |
| XENON PHARMACEUTICALS INC | COM | 98420N105 |  | 3376988 | 107891 | SH |  | SOLE |  | 107891 | 0 | 0 |

---