# EDGAR Filing Document

**Accession Number:** 0001815442
**File Stem:** 0001193125-26-073431
**Filing Date:** 2026-2
**Character Count:** 19813
**Document Hash:** acd005f5206b6a0772006e4f38ac8fcf
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-26-073431.hdr.sgml**: 20260226

**ACCESSION NUMBER**: 0001193125-26-073431

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 15

**FILED AS OF DATE**: 20260226

**DATE AS OF CHANGE**: 20260226

**EFFECTIVENESS DATE**: 20260226

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Kymera Therapeutics, Inc.
- **CENTRAL INDEX KEY:** 0001815442
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 812992166
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-293772
- **FILM NUMBER:** 26681722

**BUSINESS ADDRESS:**
- **STREET 1:** 500 NORTH BEACON STREET, 4TH FLOOR
- **CITY:** WATERTOWN
- **STATE:** MA
- **ZIP:** 02472
- **BUSINESS PHONE:** 857-285-5314

**MAIL ADDRESS:**
- **STREET 1:** 500 NORTH BEACON STREET, 4TH FLOOR
- **CITY:** WATERTOWN
- **STATE:** MA
- **ZIP:** 02472

**As filed with the Securities and Exchange Commission on February 26, 2026** 

**Registration No. 333-** 

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**WASHINGTON, D.C. 20549** 

**FORM S-8**

**REGISTRATION STATEMENT** 

***UNDER***

***THE SECURITIES ACT OF 1933***

## KYMERA THERAPEUTICS, INC.
**(Exact name of registrant as specified in its charter)** 

---

| | |
|:---|:---|
| **Delaware** | **81-2992166** |
| **(State or other jurisdiction of<br>incorporation or organization)** | **(I.R.S. Employer<br>Identification No.)** |
| **500 North Beacon Street, 4th Floor**<br> **Watertown, MA** | **02472** |
| **(Address of Principal Executive Offices)** | **(Zip Code)** |

---

**Kymera Therapeutics, Inc. 2020 Stock Option and Incentive Plan** 

**Kymera Therapeutics, Inc. Amended and Restated 2020 Employee Stock Purchase Plan** 

**(Full title of the plan)** 

**Nello Mainolfi, Ph.D.** 

**Founder, President and Chief Executive Officer** 

**Kymera Therapeutics, Inc.** 

**500 North Beacon Street, 4th Floor** 

**Watertown, MA 02472** 

**(Name and address of agent for service)** 

**(857) 285-5300** 

**(Telephone number, including area code, of agent for service)** 

***Copies to:***

**William D. Collins, Esq.** 

**Catherine Magazu, Esq.** 

**Goodwin Procter LLP** 

**100 Northern Avenue** 

**Boston, Massachusetts 02210** 

**(617) 570-1000**

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☒ | Accelerated filer | ☐ |
| Non-accelerated filer | ☐ | Smaller reporting company | ☐ |
|  |  | Emerging growth company | ☐ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

------

**EXPLANATORY NOTE** 

This Registration Statement on Form S-8 registers (i) 3,885,551 additional shares of common stock, $0.0001 par value per share (the "Common Stock"), of Kymera Therapeutics, Inc. (the "Company") under the Kymera Therapeutics, Inc. 2020 Stock Option and Incentive Plan, as amended (the "Plan") and (ii) 438,898 additional shares of Common Stock under the Kymera Therapeutics, Inc. Amended and Restated 2020 Employee Stock Purchase Plan (the "ESPP"). The additional shares are of the same class as other securities relating to the Plan and the ESPP for which the Registrant's registration statements filed on Form S-8 filed with the Securities and Exchange Commission on [August 21, 2020](http://www.sec.gov/Archives/edgar/data/1815442/000119312520227138/d250265ds8.htm) (File No. 333-248249), [March 11, 2021](http://www.sec.gov/Archives/edgar/data/1815442/000119312521077026/d152147ds8.htm) (File No. 333-254122), [February 24, 2022](http://www.sec.gov/Archives/edgar/data/1815442/000119312522051086/d297315ds8.htm) (File No. 333-262947), [February 23, 2023](http://www.sec.gov/Archives/edgar/data/1815442/000119312523045632/d446122ds8.htm) (File No. 333-269928), [February 22, 2024](http://www.sec.gov/Archives/edgar/data/1815442/000119312524042097/d781388ds8.htm) (File No. 333-277242) and [February 27, 2025](http://www.sec.gov/Archives/edgar/data/1815442/000119312525037613/d934878ds8.htm) (File No. 333-285308) are effective. The information contained in the Registrant's registration statements on Form S-8 (Registration Nos. 333-248249, 333-254122, 333-262947, 333-269928, 333-277242 and 333-285308) are hereby incorporated by reference pursuant to General Instruction E.

------

**Part II** 

**INFORMATION REQUIRED IN THE REGISTRATION STATEMENT** 

**Item 8. Exhibits.** 

---

| | |
|:---|:---|
| **Exhibit<br>No.** | **Description** |
| &nbsp;&nbsp;&nbsp;&nbsp;4.1 | [Fourth Amended and Restated Certificate of Incorporation of the Registrant (Incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-39460) filed with the Securities and Exchange Commission on August 25, 2020.](http://www.sec.gov/Archives/edgar/data/1815442/000119312520229873/d45025dex31.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;4.2 | [Second Amended and Restated Bylaws of the Registrant (Incorporated by reference to Exhibit 3.2 to the Registrant's Current Report on Form 8-K (File No. 001-39460) filed with the Securities and Exchange Commission on August 25, 2020.](http://www.sec.gov/Archives/edgar/data/1815442/000119312520229873/d45025dex32.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;4.3 | [Specimen Common Stock Certificate of the Registrant (Incorporated by reference to Exhibit 4.1 to the Registrant's Registration Statement on Form S-1/A (File No. 333-240264) filed with the Securities and Exchange Commission on August 17, 2020).](http://www.sec.gov/Archives/edgar/data/1815442/000119312520221618/d940105dex41.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;4.4 | [Registration Rights Agreement by and among the Registrant and certain of its stockholders dated June 26, 2025 (Incorporated by reference to Exhibit 10.1 to the Registrant's Current Report on Form 8-K (File No. 001-39460) filed with the Securities and Exchange Commission on June 27, 2025.](http://www.sec.gov/Archives/edgar/data/1815442/000119312525151393/d85382dex101.htm) |
| &nbsp;&nbsp;&nbsp;&nbsp;5.1\* | [Opinion of Goodwin Procter LLP.](d15670dex51.htm) |
| 23.1\* | [Consent of Ernst & Young LLP, independent registered public accounting firm.](d15670dex231.htm) |
| 23.2\* | [Consent of Goodwin Procter LLP (included in Exhibit 5.1).](d15670dex51.htm) |
| 24.1\* | [Power of Attorney (included on signature page).](#tx15670_1) |
| 99.1 | [2020 Stock Option and Incentive Plan and forms of award agreements thereunder (Incorporated by reference to Exhibit 10.2 to the Registrant's Registration Statement on Form S-1/A (File No. 333-240264) filed with the Securities and Exchange Commission on August 17, 2020).](http://www.sec.gov/Archives/edgar/data/1815442/000119312520221618/d940105dex102.htm) |
| 99.2 | [Amendment No. 1 to the 2020 Stock Option and Incentive Plan (Incorporated by reference to Exhibit 10.1 to the Registrant's Current Report on Form 8-K (File No. 001-39460) filed with the Securities and Exchange Commission on June 20, 2024).](http://www.sec.gov/Archives/edgar/data/1815442/000119312524164550/d841500dex101.htm) |
| 99.3 | [Amended and Restated 2020 Employee Stock Purchase Plan (Incorporated by reference to Exhibit 10.1 to the Registrant's Quarterly Report on Form 10-Q (File No. 001-39460) filed with the Securities and Exchange Commission on November 5, 2020).](http://www.sec.gov/Archives/edgar/data/1815442/000156459020050872/kymr-ex101_540.htm) |
| 107\* | [Filing Fee Table.](d15670dexfilingfees.htm) |

---

\* Filed herewith.

------

**SIGNATURES** 

Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Watertown, Commonwealth of Massachusetts, on February 26, 2026.

---

| | |
|:---|:---|
| **KYMERA THERAPEUTICS, INC.** | **KYMERA THERAPEUTICS, INC.** |
| By: | /s/ Nello Mainolfi |
|  | Name: Nello Mainolfi, Ph.D. |
|  | Title: Founder, President and Chief Executive Officer |

---

**POWER OF ATTORNEY AND SIGNATURES** 

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints each of Nello Mainolfi, Ph.D. and Bruce Jacobs, CFA, MBA as such person's true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution in each of them, for such person in such person's name, place and stead, in any and all capacities, to sign for us and in our names in the capacities indicated below the Registration Statement on Form S-8 of Kymera Therapeutics, Inc., and any or all amendments (including post-effective amendments), and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite or necessary to be done in connection therewith and about the premises, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents or any of them, or substitutes of any of them, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement on Form S-8 has been signed by the following persons in the capacities and on the dates indicated.

------

---

| | | |
|:---|:---|:---|
| **Signature** | **Title** | **Date** |
| /s/ Nello Mainolfi<br> Nello Mainolfi, Ph.D. | Director, Founder, President and Chief Executive Officer<br> (Principal Executive Officer) | February 26, 2026 |
| /s/ Bruce Jacobs<br> Bruce Jacobs, CFA, MBA | Chief Financial Officer<br> (Principal Financial Officer)<br> (Principal Accounting Officer) | February 26, 2026 |
| /s/ Jeffrey Albers<br> Jeffrey Albers, J.D., MBA | Director | February 26, 2026 |
| /s/ Felix J. Baker<br> Felix J. Baker, Ph.D. | Director | February 26, 2026 |
| /s/ Bruce Booth<br> Bruce Booth, D.Phil. | Director | February 26, 2026 |
| /s/ Pamela Esposito<br> Pamela Esposito, Ph.D. | Director | February 26, 2026 |
| /s/ Gorjan Hrustanovic<br> Gorjan Hrustanovic, Ph.D. | Director | February 26, 2026 |
| /s/ John Maraganore<br> John Maraganore, Ph.D. | Director | February 26, 2026 |
| /s/ Elena Ridloff<br> Elena Ridloff, CFA | Director | February 26, 2026 |
| /s/ Victor Sandor<br> Victor Sandor, M.D | Director | February 26, 2026 |

---

## Exhibit 5.1

**Exhibit 5.1** 

---

| | |
|:---|:---|
| ![LOGO](g15670g0221015640647.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Goodwin Procter LLP<br> 100 Northern Avenue<br> Boston, MA 02210<br>goodwinlaw.com<br> +1 617 570 1000 |

---

February 26, 2026

Kymera Therapeutics, Inc.

500 North Beacon Street, 4th Floor

Watertown, MA 02472

Re: <u>Securities Being Registered under Registration Statement on Form S-8</u>

We have acted as your counsel in connection with your filing of a Registration Statement on Form S-8 (the "Registration Statement") pursuant to the Securities Act of 1933, as amended (the "Securities Act"), on or about the date hereof relating to an aggregate of (i) 3,885,551 shares (the "Plan Shares") of common stock, par value $0.0001 per share ("Common Stock"), of Kymera Therapeutics, Inc., a Delaware corporation (the "Company"), that may be issued pursuant to the Kymera Therapeutics, Inc. 2020 Stock Option and Incentive Plan (as amended, the "Incentive Plan") and (ii) 438,898 shares (the "ESPP Shares" and together with the Plan Shares, the "Shares") of the Common Stock that may be issued pursuant to the Kymera Therapeutics, Inc. Amended and Restated 2020 Employee Stock Purchase Plan (the "ESPP" and, together with the Incentive Plan, the "Plans").

We have reviewed such documents and made such examination of law as we have deemed appropriate to give the opinion set forth below. We have relied, without independent verification, on certificates of public officials and, as to matters of fact material to the opinion set forth below, on certificates of officers of the Company.

For purposes of the opinion set forth below, we have assumed that, at the time Shares are issued, the total number of then unissued Shares, when added to the number of shares of Common Stock issued, subscribed for, or otherwise committed to be issued, does not exceed the number of shares of Common Stock authorized by the Company's certificate of incorporation.

The opinion set forth below is limited to the Delaware General Corporation Law.

Based on the foregoing, we are of the opinion that the Shares have been duly authorized and, when delivered against payment therefor in accordance with the terms of the Plans, will be validly issued, fully paid and nonassessable.

------

Kymera Therapeutics, Inc.

February 26, 2026

This opinion letter and the opinion it contains shall be interpreted in accordance with the Core Opinion Principles as published in 74 *Business Lawyer* 815 (Summer 2019).

We hereby consent to the inclusion of this opinion as Exhibit 5.1 to the Registration Statement. In giving our consent, we do not admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations thereunder.

---

| |
|:---|
| Very truly yours, |
| /s/ Goodwin Procter LLP |
| GOODWIN PROCTER LLP |

---

## Exhibit 23.1

**Exhibit 23.1** 

**CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM** 

We consent to the incorporation by reference in the Registration Statement (Form S-8) pertaining to the Kymera Therapeutics, Inc. 2020 Stock Option and Incentive Plan and the Kymera Therapeutics, Inc. Amended and Restated 2020 Employee Stock Purchase Plan of our reports dated February 26, 2026, with respect to the consolidated financial statements of Kymera Therapeutics, Inc. and the effectiveness of internal control over financial reporting of Kymera Therapeutics, Inc. included in its Annual Report (Form 10-K) for the year ended December 31, 2025, filed with the Securities and Exchange Commission.

/s/ Ernst & Young LLP

Boston, Massachusetts

February 26, 2026

## Ex-Filing

?xml version='1.0' encoding='ASCII'? EX-FILING FEES

---

| |
|:---|
| **Calculation of Filing Fee Tables**  |
| &nbsp;&nbsp;&nbsp;&nbsp;**S-8**  |
| &nbsp;&nbsp;&nbsp;&nbsp;**Kymera Therapeutics, Inc.**  |

---

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| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | **Security Type**  | **Security Class Title**  | **Fee Calculation Rule**  | **Amount Registered**  | **Proposed Maximum Offering Price Per Unit**  | **Maximum Aggregate Offering Price**  | **Fee Rate**  | **Amount of Registration Fee**  |
| 1 | Equity | Kymera Therapeutics, Inc. 2020 Stock Option and Incentive Plan Common Stock, $0.0001 par value per share | Other | 3885551 | $87.44 | $339752579.44 | 0.0001381 | $46919.83 |
| 2 | Equity | Kymera Therapeutics, Inc. Amended and Restated 2020 Employee Stock Purchase Plan Common Stock, $0.0001 par value per share | Other | 438898 | $74.32 | $32618899.36 | 0.0001381 | $4504.67 |
| Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: |  | $372371478.80  |  | $51424.50  |
| Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  |  |  |  | $0.00  |
| Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  |  |  |  | $51424.50  |

---

 **Offering Note** <br>

<sup>1</sup> Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this registration statement on Form S-8 shall also cover any additional shares of common stock, $0.0001 par value per share ("Common Stock"), of Kymera Therapeutics, Inc. (the "Registrant") which become issuable under the Kymera Therapeutics, Inc. 2020 Stock Option and Incentive Plan (as amended, the "Plan"), by reason of any stock dividend, stock split, recapitalization or any other similar transaction effected without the receipt of consideration which results in an increase in the number of the Registrant's outstanding shares of Common Stock. Pursuant to Rule 416 under the Securities Act, this registration statement on Form S-8 shall also cover any additional shares of Common Stock of the Registrant which become issuable under the Kymera Therapeutics, Inc. Amended and Restated 2020 Employee Stock Purchase Plan (the "ESPP"), by reason of any stock dividend, stock split, recapitalization or any other similar transaction effected without the receipt of consideration which results in an increase in the number of the Registrant's outstanding shares of Common Stock. The amount registered represents an automatic increase of 3,885,551 shares of Common Stock to the number of shares available for issuance under the Plan, effective January 1, 2026. Shares available for issuance under the Plan were previously registered on registration statements on Form S-8 filed with the Securities and Exchange Commission on August 21, 2020 (File No. 333-248249), March 11, 2021 (File No. 333-254122), February 24, 2022 (File No. 333-262947), February 23, 2023 (File No. 333-269928), February 22, 2024 (File No. 333-277242) and February 27, 2025 (File No. 333-285308). The proposed maximum offering price per unit is estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and (h) of the Securities Act, and based on the average of the high and low sale prices of the Registrant's Common Stock, as quoted on the Nasdaq Global Market, on February 20, 2026.

<sup>2</sup> The amount registered represents an automatic increase of 438,898 shares of Common Stock to the number of shares available for issuance under the ESPP, effective January 1, 2026. Shares available for issuance under the ESPP were previously registered on registration statements on Form S-8 filed with the Securities and Exchange Commission on August 21, 2020 (File No. 333-248249), March 11, 2021 (File No. 333-254122), February 24, 2022 (File No. 333-262947), February 23, 2023 (File No. 333-269928), February 22, 2024 (File No. 333-277242) and February 27, 2025 (File No. 333-285308). The proposed maximum offering price per unit of $74.32 per share, which is 85% of the average of the high and low sale prices of the Common Stock of the Registrant as quoted on the Nasdaq Global Market on February 20, 2026, is set forth solely for purposes of calculating the registration fee pursuant to Rules 457(c) and (h) of the Securities Act and has been used as these shares are without a fixed price. Pursuant to the ESPP, the purchase price of the shares of Common Stock reserved for issuance thereunder will be 85% of the fair market value of a share of Common Stock on the first trading day of the offering period or on the exercise date, whichever is less.

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| | |
|:---|:---|
| | |
| **Rule 457(p)** | **Rule 457(p)** |
| Fee Offset Claims | N/A |
| Fee Offset Sources | N/A |

---