# EDGAR Filing Document

**Accession Number:** 0001745999
**File Stem:** 0001193125-26-161512
**Filing Date:** 2026-4
**Character Count:** 210930
**Document Hash:** 935e5ba6da6ba5b6825d2d57385ea9b2
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-26-161512.hdr.sgml**: 20260417

**ACCESSION NUMBER**: 0001193125-26-161512

**CONFORMED SUBMISSION TYPE**: DEF 14A

**PUBLIC DOCUMENT COUNT**: 19

**CONFORMED PERIOD OF REPORT**: 20260603

**FILED AS OF DATE**: 20260417

**DATE AS OF CHANGE**: 20260417

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Beam Therapeutics Inc.
- **CENTRAL INDEX KEY:** 0001745999
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** DEF 14A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-39208
- **FILM NUMBER:** 26871517

**BUSINESS ADDRESS:**
- **STREET 1:** 26 LANDSDOWNE STREET
- **CITY:** CAMBRIDGE
- **STATE:** MA
- **ZIP:** 02139
- **BUSINESS PHONE:** 857-327-8775

**MAIL ADDRESS:**
- **STREET 1:** 26 LANDSDOWNE STREET
- **CITY:** CAMBRIDGE
- **STATE:** MA
- **ZIP:** 02139

?xml version='1.0' encoding='ASCII'? DEF 14A

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**Washington, D.C. 20549** 

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SCHEDULE 14A

**Proxy Statement Pursuant to Section 14(a) of the** 

**Securities Exchange Act of 1934** 

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Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐

Check the appropriate box:

☐ Preliminary Proxy Statement

☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

☒ Definitive Proxy Statement

☐ Definitive Additional Materials

☐ Soliciting Material under §240.14a-12

BEAM THERAPEUTICS INC.

**(Name of Registrant as Specified in Its Charter)** 

**(Name of Person(s) Filing Proxy Statement if other than Registrant)** 

Payment of Filing Fee (Check the appropriate box):

☒ No fee required.

☐ Fee paid previously with preliminary materials.

☐ Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11

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![img205556861_0.gif](img205556861_0.gif)

**BEAM THERAPEUTICS INC.**

**238 Main Street**

**Cambridge, MA 02142**

**NOTICE OF 2026 ANNUAL MEETING OF STOCKHOLDERS** 

**To Be Held on June 3, 2026**

Dear Stockholders:

We are pleased to notify you that we will hold the 2026 annual meeting of the stockholders (the "Annual Meeting") of Beam Therapeutics Inc. ("Beam", "we", "us", or "our") via live webcast on June 3, 2026, at 10:30 a.m.., Eastern Daylight Time, in a virtual meeting format at *www.virtualshareholdermeeting.com/BEAM2026* for the following purposes:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.To elect John Evans, John Maraganore, Ph.D., and Christi Shaw as our Class III directors, to serve for three-year terms until the 2029 annual meeting of our stockholders, and until his or her successor shall have been duly elected and qualified;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.To ratify the appointment of Deloitte & Touche LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2026;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.To approve, on an advisory basis, the compensation of our named executive officers ("NEOs"); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.To transact such other business as may properly come before the Annual Meeting or any continuations, adjournments and postponements thereof.

Our Board of Directors has established the close of business on April 7, 2026 as the record date for the Annual Meeting. This means that you are entitled to vote at the Annual Meeting (by remote communication or by proxy) if our stock records show that you owned our common stock at that time.

Whether you plan to attend the Annual Meeting or not, it is important that you cast your vote either by remote communication at the virtual meeting or by proxy. You may vote over the Internet, telephone or by mail. You are urged to vote in accordance with the instructions set forth in this proxy statement. We encourage you to vote by proxy so that your shares will be represented and voted at the Annual Meeting, whether or not you can attend the virtual meeting. You will need the 16-digit control number included with the Notice, on your proxy card, or the instructions that accompany your proxy materials to attend the Annual Meeting virtually via the Internet.

Thank you for your continued support of Beam Therapeutics Inc. We look forward to seeing you at the Annual Meeting.

By Order of the Board of Directors,

![img205556861_1.jpg](img205556861_1.jpg)

John Evans

Chief Executive Officer and Director

April 17, 2026

Cambridge, Massachusetts

**Important Notice Regarding the Availability of Proxy Materials for the Stockholder Meeting to Be Held on June 3, 2026:** Under Securities and Exchange Commission rules that allow companies to furnish proxy materials to stockholders over the Internet, we have elected to make our proxy materials available to all of our stockholders over the Internet. We will be able to provide stockholders with the information they need, while at the same time conserving natural resources and lowering the cost of delivery. On or about April 17, 2026, we will commence sending to our stockholders a Notice of Internet Availability of Proxy Materials (the "Notice"), containing instructions on how to access our proxy statement for the Annual Meeting and our 2025 Annual Report on Form 10-K to stockholders. The Notice also provides instructions on how to vote online or vote by phone and includes instructions on how to receive a paper copy of the proxy materials by mail.

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**Virtual Meeting Format**: The Annual Meeting will be a completely virtual meeting, which will be conducted via live webcast. There will not be a physical meeting location, and stockholders will not be able to attend the Annual Meeting in person. This means that you will be able to attend the Annual Meeting online, vote your shares and submit your questions during the meeting by visiting *www.virtualshareholdermeeting.com/BEAM2026*. Details regarding how to attend the Annual Meeting online are more fully described in the Notice and this proxy statement.

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**TABLE OF CONTENTS**

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| | |
|:---|:---|
|  | **Page** |
| [<u>NOTICE OF 2026 ANNUAL MEETING OF STOCKHOLDERS</u>](#notice_2021_annual_meeting_stockholders) |  |
| [<u>PROXY STATEMENT FOR 2026 ANNUAL MEETING OF STOCKHOLDERS</u>](#proxy_statement_for_2021_annual_meeting_) | 1 |
| [<u>IMPORTANT NOTICE REGARDING THE AVAILABILITY OF PROXY MATERIALS</u>](#important_notice_regarding_availability) | 1 |
| [<u>INFORMATION ABOUT THE ANNUAL MEETING AND VOTING</u>](#information_about_annual_meeting_voting) | 2 |
| [<u>MANAGEMENT AND CORPORATE GOVERNANCE</u>](#management_corporate_governance) | 6 |
| [<u>EXECUTIVE OFFICERS</u>](#executive_ficers) | 15 |
| [<u>COMPENSATION DISCUSSION AND ANALYSIS</u>](#compensation_discussion_and_analysis) | 16 |
| [<u>COMPENSATION COMMITTEE REPORT</u>](#compensation_committee_report) | 24 |
| [<u>EXECUTIVE COMPENSATION</u>](#executive_compensation) | 25 |
| [<u>PAY VERSUS PERFORMANCE</u>](#pay_versus_performance) | 37 |
| [<u>DIRECTOR COMPENSATION</u>](#director_compensation) | 40 |
| [<u>AUDIT COMMITTEE REPORT</u>](#audit_committee_report) | 42 |
| [<u>DELINQUENT SECTION 16(a) REPORTS</u>](#delinquent_section_16a_reports) | 43 |
| [<u>CERTAIN RELATIONSHIPS AND RELATED PERSON TRANSACTIONS</u>](#certain_relationships_related_person_tra) | 44 |
| [<u>PROPOSAL NO. 1—ELECTION OF DIRECTORS</u>](#proposal_no_1election_directors) | 46 |
| [<u>PROPOSAL NO. 2—RATIFICATION OF SELECTION OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM</u>](#proposal_no_2ratification_selection_inde) | 47 |
| [<u>PROPOSAL NO. 3—ADVISORY VOTE ON NAMED EXECUTIVE OFFICER COMPENSATION</u>](#proposal_3) | 49 |
| [<u>TRANSACTION OF OTHER BUSINESS</u>](#transaction_of_other_business) | 50 |
| [<u>SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT</u>](#security_ownership_certain_beneficial_ow) | 51 |
| [<u>SECURITIES AUTHORIZED FOR ISSUANCE UNDER EQUITY COMPENSATION PLANS</u>](#equity_compensation_plans) | 54 |
| [<u>GENERAL MATTERS</u>](#general_matters) | 55 |

---

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![img205556861_2.gif](img205556861_2.gif)

**BEAM THERAPEUTICS INC.**

**238 Main Street**

**Cambridge, MA 02142**

**PROXY STATEMENT FOR 2026 ANNUAL MEETING OF STOCKHOLDERS** 

**To Be Held on June 3, 2026** 

The Board of Directors (our "Board") of Beam Therapeutics Inc. ("we," "us," "our," "Company," or "Beam") is soliciting proxies from stockholders for its use at the 2026 annual meeting of our stockholders (the "Annual Meeting"), and at any continuation, postponement or adjournment of that meeting. The Annual Meeting is scheduled to be held on June 3, 2026, at 10:30 a.m., Eastern Daylight Time, in a virtual meeting format at *www.virtualshareholdermeeting.com/BEAM2026*. There will not be a physical meeting location, and stockholders will not be able to attend the Annual Meeting in person. Further information about how to attend the Annual Meeting online is included in this proxy statement.

All properly submitted proxies will be voted in accordance with the instructions contained in those proxies. If no instructions are specified, the shares represented by the proxies will be voted in accordance with the recommendation of our Board with respect to each of the matters set forth in the accompanying Notice of Meeting. If you are a stockholder of record, you may change your vote or revoke your proxy at any time before it is exercised at the Annual Meeting by following the instructions set forth in this proxy statement.

On or about April 17, 2026, we will commence sending the Important Notice Regarding the Availability of Proxy Materials (the "Notice") to all stockholders entitled to vote at the Annual Meeting.

**IMPORTANT NOTICE REGARDING THE AVAILABILITY OF PROXY MATERIALS** 

**This proxy statement and our 2025 Annual Report on Form 10-K for the fiscal year ended December 31, 2025, as filed with the Securities and Exchange Commission (the "SEC") on February 24, 2026 (the "Annual Report on Form 10-K"), which include our audited financial statements, are available for viewing, printing and downloading at *www.proxyvote.com*. To view these materials, please have your 16-digit control number(s) available that appears on your Notice or proxy card. On this website, you can also elect to receive distributions of our proxy statements and annual reports to stockholders for future annual meetings by electronic delivery. For specific instructions on making such an election, please refer to the instructions on your proxy card or voting instruction form.**

**Additionally, you can find a copy of our Annual Report on Form 10-K on the website of the SEC at *www.sec.gov*, or in the "Financials & Filings" tab of the "Investors" section of our website at** www.beamtx.com**. You may also obtain a printed copy of our Annual Report on Form 10-K, including our financial statements, free of charge, from us by following the instructions included on the Notice or by sending a written request to: Beam Therapeutics Inc., 238 Main Street, Cambridge, MA 02142, Attention: Secretary.** 

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**INFORMATION ABOUT THE ANNUAL MEETING AND VOTING** 

**Purposes of the Meeting** 

The purposes of the Annual Meeting are:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.To elect John Evans, John Maraganore, Ph.D., and Christi Shaw as our Class III directors, to serve for three-year terms until the 2029 annual meeting of our stockholders, and until his or her successor shall have been duly elected and qualified;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.To ratify the appointment of Deloitte & Touche LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2026;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.To approve, on an advisory basis, the compensation of our named executive officers ("NEOs"); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.To transact such other business as may properly come before the Annual Meeting or any continuations, adjournments and postponements thereof.

**Stockholders Entitled to Vote at the Meeting** 

Our Board has established the close of business on April 7, 2026 as the "record date" for the Annual Meeting. This means that you are entitled to vote at the Annual Meeting (and any adjournments) if our records show that you owned our common stock at that time. As of the record date, 102,745,693 shares of our common stock were outstanding. Each outstanding share of common stock as of the record date is entitled to one vote on each matter properly to come before the Annual Meeting and can be voted only if the record owner of that share, determined as of the record date, is present by remote communication at the meeting or represented by a properly submitted proxy. A list of stockholders entitled to vote at the Annual Meeting will be available for stockholder inspection at the headquarters of the Company, 238 Main Street, Cambridge, MA 02142, during ordinary business hours, for a period of 10 days prior to the Annual Meeting.

**Voting Shares That You Hold In Your Name** 

If you are a stockholder of record and your shares are registered directly in your name, you may:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•VOTE BY INTERNET – *www.proxyvote.com*. Use the Internet to transmit your voting instructions up until 11:59 p.m., Eastern Daylight Time, on June 2, 2026. Have the Notice or your proxy card in hand when you access the website. Follow the steps outlined on the secured website.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•VOTE BY MAIL – If you requested and received a proxy card by mail, mark, sign and date your proxy card and return it in the postage-paid envelope we will provide or mail it to Vote Processing, c/o Broadridge, 51 Mercedes Way, Edgewood, NY 11717.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•VOTE BY PHONE – Use a touch tone phone by calling the toll-free number 1-800-690-6903 to transmit your voting instructions up until 11:59 p.m., Eastern Daylight Time, on June 2, 2026. Have the Notice or your proxy card in hand when you access the phone number. Follow the steps outlined on the phone line.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•VOTE BY REMOTE COMMUNICATION AT THE VIRTUAL MEETING – See "Attending the Annual Meeting," below.

**Virtual Meeting** 

The Annual Meeting will be a completely virtual meeting conducted via live webcast. To participate in the Annual Meeting virtually via the Internet, please visit *www.virtualshareholdermeeting.com/BEAM2026*.You will need the 16-digit control number included on your Notice, your proxy card or the instructions that accompanied your proxy materials.

If you are a beneficial holder, instructions should also be provided on the voting instruction card provided by your bank or brokerage firm. If you do not have your 16-digit control number and attend the meeting online, you will be able to listen to the meeting only — you will not be able to vote or submit questions during the meeting.

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**Attending the Annual Meeting** 

The Annual Meeting will be held entirely online at *www.virtualshareholdermeeting.com/BEAM2026*. There will not be a physical meeting location, and stockholders will not be able to attend the Annual Meeting in person. A summary of the information you need to attend the Annual Meeting online is provided below:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Instructions on how to attend and participate via the Internet, including how to demonstrate proof of common stock ownership, are posted at *www.virtualshareholdermeeting.com/BEAM2026*.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Questions regarding how to attend and participate via the Internet will be answered by calling 1-844-986-0822 (U.S.) and 303-562-9302 (International) on the day before the Annual Meeting and the day of the Annual Meeting.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Please have your 16-digit control number to enter the Annual Meeting.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Stockholders may submit questions while attending the Annual Meeting via the Internet.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•The meeting webcast will begin promptly at 10:30 a.m., Eastern Daylight Time.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•We encourage you to access the meeting prior to the start time. Online check-in will begin at 10:00 a.m., Eastern Daylight Time, and you should allow ample time for the check-in procedures.

Webcast replay of the Annual Meeting will be available until the earlier of June 3, 2027 or the date of the next annual meeting of stockholders to be held in 2027.

**Technical Assistance for the Virtual Meeting** 

We encourage stockholders to log into the virtual Annual Meeting 15 minutes prior to the start of the Annual Meeting to test their Internet connectivity. If you encounter any difficulties while accessing the virtual meeting during the check-in or meeting time, a technical assistance phone number will be made available on the virtual meeting registration page 15 minutes prior to the start of the meeting. Technical support will be available starting at 10:15 a.m. Eastern Daylight Time on June 3, 2026 and will remain available until the meeting has finished.

**Voting Shares That You Hold in Brokerage or Similar Accounts** 

Many stockholders hold their shares through a broker, bank or other nominee rather than directly in their own name. If you hold your shares in one of these ways, you are considered a beneficial owner, not a record owner, and you therefore have no direct vote on any matter to come before the Annual Meeting. Your broker, bank or nominee will send you voting instructions for you to use in directing the broker, bank or nominee in how to vote your shares. Your broker, bank or nominee may allow you to deliver your voting instructions via the telephone or the Internet.

A "broker non-vote" occurs when a broker, bank or other nominee holding shares for a beneficial owner does not vote the shares on a proposal because the broker, bank or other nominee does not have discretionary voting power for a particular item and has not received instructions from the beneficial owner regarding how to vote. Brokers, banks or other nominees who hold shares for the accounts of their clients have discretionary authority to vote shares if specific instructions are not given with respect to certain matters. Although the determination of whether a broker, bank or other nominee will have discretionary voting power for a particular item is typically determined only after proxy materials are filed with the SEC, we expect that the proposal on ratification of the appointment of our independent registered public accounting firm (Proposal 2) will be a matter on which a broker, bank or other nominee will have discretionary voting authority and that the election of each nominee for Class III director (Proposal 1) and the advisory vote to approve the compensation of our NEOs (Proposal 3) will be matters on which a broker, bank or other nominee will not have discretionary voting authority. Accordingly, if you hold your shares through a broker, bank or other nominee and you do not timely provide your broker, bank or other nominee with specific instructions on how to vote your shares, we expect that your broker, bank or other nominee will not be authorized to cast a vote on your behalf on Proposals 1 or 3 but will be authorized to cast a vote on your behalf, in its discretion, on Proposal 2. In such cases, a "broker non-vote" may be entered with respect to your shares on Proposals 1 or 3 to reflect that your broker was present with respect to your shares at the meeting but was not exercising voting rights on your behalf with respect to those shares. Broker non-votes will have no effect on the outcome of any proposal.

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**Your Voting Options on Each of the Proposals** 

You may vote "for," "against" or "abstain" with respect to the election of each nominee for director (Proposal 1), the ratification of the appointment of Deloitte & Touche LLP as our independent registered public accounting firm (Proposal 2) and the advisory vote to approve the compensation of our NEOs (Proposal 3).

If any other matter is presented at the Annual Meeting, your proxy provides that your shares will be voted by the proxy holder named in the proxy card in accordance with his or her best judgment. At the time this proxy statement was first made available, we knew of no matters that needed to be acted on at the Annual Meeting, other than those discussed in this proxy statement.

**Our Board's Voting Recommendations** 

Our Board recommends that you vote:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•"**FOR**" the election of John Evans, John Maraganore, Ph.D., and Christi Shaw as our Class III directors (Proposal 1);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•"**FOR**" the ratification of the appointment of Deloitte & Touche LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2026 (Proposal 2); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•"**FOR**" the advisory vote to approve the compensation of our NEOs (Proposal 3).

If any other matter is properly brought before the Annual Meeting, the Company – through the individuals named in the Company's proxy card and acting as the "proxy holder," or his or her designee, and pursuant to the blanket authorization granted under the proxy – will vote your shares on that matter in accordance with the discretion and judgment of the proxy holder.

**Required Votes to Approve Each Proposal** 

As a stockholder, you are entitled to cast one vote per share for the nominee for election as director at the Annual Meeting. A majority of the votes properly cast for election of a director will effect such election. A majority of the votes properly cast at the Annual Meeting will also approve (i) the proposal to ratify the appointment of Deloitte & Touche LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2026, (ii) the proposal to approve, on an advisory basis, the compensation of our NEOs, and (iii) all other matters that arise at the Annual Meeting. "Abstentions" will not be counted as votes cast on the proposals and will have no effect on the outcome of any proposal. For a discussion of how "broker non-votes" will be treated, see the discussion under "Voting Shares That You Hold in Brokerage or Similar Accounts."

Please note that because the votes on the ratification of Deloitte & Touche LLP and the advisory vote to approve the compensation of our NEOs are advisory in nature, the results of such votes will not be binding upon us, our Board or its committees.

**Quorum** 

The presence, virtually via the Internet or by proxy, of holders of at least a majority of the total number of outstanding shares entitled to vote is necessary to constitute a quorum for the transaction of business at the Annual Meeting. Abstentions, if any, will be counted for purposes of determining whether a quorum is present for the transaction of business at the Annual Meeting. Because we expect that brokers, banks or other nominees will be able to vote on at least one proposal, we expect that these shares will be counted for purposes of determining whether a quorum is present at the Annual Meeting.

**Revocation of Proxies or Voting Instructions** 

A stockholder of record who has voted by proxy using any method in response to this solicitation may revoke it before it is exercised at the Annual Meeting by executing and delivering a timely and valid later-dated proxy card (provided we receive the later proxy card before the Annual Meeting date), by a timely and valid later Internet or telephone vote, by voting by remote communication at the Annual Meeting or by giving written notice to Christine Bellon, our Company secretary (the "Secretary"). Attendance at the Annual Meeting online will not have the effect of revoking a proxy unless the stockholder gives proper written notice of revocation to our Secretary before the proxy is exercised or the stockholder votes by remote communication at the Annual Meeting. Beneficial owners who have directed their broker, bank or nominee as to how to vote their shares should contact their broker, bank or nominee for instructions as to how they may revoke or change those voting directions.

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**Solicitation of Proxies** 

Our Board is making this solicitation of proxies for our Annual Meeting. We will bear all costs of such solicitation, including the cost of preparing and distributing this proxy statement and the enclosed form of proxy and including the cost of hosting the virtual Annual Meeting. After the initial distribution of this proxy statement, our directors, officers and employees may solicit proxies personally, by telephone, by email or otherwise. These directors, officers and employees will not receive additional compensation for the solicitation but may be reimbursed for out-of-pocket expenses incurred in connection with the solicitation. Brokerage houses and other custodians, nominees and fiduciaries will be requested to forward soliciting materials to beneficial owners of shares held by them for the accounts of beneficial owners. We may reimburse brokerage houses and other custodians, nominees and fiduciaries for reasonable, out-of-pocket expenses for forwarding these proxy materials, according to certain regulatory fee schedules.

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**MANAGEMENT AND CORPORATE GOVERNANCE** 

**Board Composition and Structure** 

Our fourth amended and restated certificate of incorporation (our "certificate of incorporation") states that our Board shall consist of not fewer than three and not more than fifteen members, and the precise number of directors shall be fixed by a resolution of our Board. Each of our directors holds office until his or her successor is duly elected and qualified or until his or her death, resignation or removal. Our certificate of incorporation provides that our directors may be removed only for cause by the affirmative vote of the holders of at least seventy-five percent (75%) of the voting power of the outstanding shares of capital stock of the Company entitled to vote generally in the election of directors, voting together as a single class, at a meeting of the stockholders called for that purpose. Any vacancy on our Board, including a vacancy that results from an increase in the number of directors, may be filled by a vote of the majority of the directors then in office.

Our certificate of incorporation provides that our Board is divided into three classes of directors, with the classes as nearly equal in number as possible. Each of our directors identified below serves in the class indicated. Subject to any earlier death, resignation or removal in accordance with the terms of our certificate of incorporation and our second amended and restated bylaws (our "bylaws"), our Class III directors who are re-elected at the Annual Meeting will serve three-year terms until the 2029 annual meeting of stockholders; our Class II directors are currently serving a term that expires at the 2028 annual meeting of stockholders; and our Class I directors are currently serving a term that expires at the 2027 annual meeting of stockholders. Any additional directorships resulting from an increase in the number of directors will be apportioned by our Board among the three classes.

Our Board is currently comprised of seven members. Below is a list of the names, ages as of April 17, 2026 and classification of the individuals who currently serve as our directors.

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| | | |
|:---|:---|:---|
| **Name** | **Age** | **Position** |
| Graham Cooper | 56 | Director (Class I) |
| Chirfi Guindo | 60 | Director (Class I) |
| Mark Fishman, M.D. | 75 | Director (Class II) |
| Kathleen Walsh | 70 | Director (Class II) |
| John Evans | 48 | Director (Class III) |
| John Maraganore, Ph.D. | 63 | Director (Class III) |
| Christi Shaw | 59 | Director (Class III) |

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**Director Biographies**

Information concerning our directors is set forth below. The biographical description of each director includes the specific experience, qualifications, attributes and skills that led to our Board's conclusion at the time of filing this proxy statement that each person listed below should serve as a director.

***Class III Director Nominees***

**John Evans** has served as our Chief Executive Officer and as a member of our board of directors since January 2017. Mr. Evans has significant experience as a company builder, dealmaker, and drug developer in the biotechnology industry. Mr. Evans previously served as a Venture Partner with ARCH Venture Partners from April 2017 to March 2021, and as a member of the board of directors of Verve Therapeutics from August 2018 to August 2022 and of Prime Medicines Inc. from September 2019 to September 2022. Mr. Evans was previously an early employee and member of the leadership team at Agios Pharmaceuticals, from September 2009 until April 2017, most recently serving as Senior Vice President for Corporate Development and Portfolio Leadership. Prior to joining Agios, Mr. Evans worked at Infinity Pharmaceuticals, McKinsey & Company's pharmaceuticals practice and MedImmune. Mr. Evans holds an MBA in Healthcare Management from Wharton, a M.S. in Biotechnology from the University of Pennsylvania, and a B.A. in English with distinction from Yale University. We believe that Mr. Evans is qualified to serve on our board of directors based on his extensive experience in the pharmaceutical industry and his expansive knowledge of our company based on his role as Chief Executive Officer.

**John Maraganore, Ph.D.,** has served on our board of directors since November 2021. He is the CEO and Principal of JMM Innovations, LLC and the Co-CEO of Corsera Health, a biotechnology company. He was previously the founding CEO and a director of Alnylam Pharmaceuticals ("Alnylam") from 2002 to 2021, where he built and led the company from early platform research on RNA interference through global approval and commercialization of the first three RNAi medicines including ONPATTRO®, GIVLAARI®, and OXLUMO®. Prior to Alnylam, Dr. Maraganore served as an officer and a member of the management team for Millennium Pharmaceuticals, Inc. ("Millennium"), most recently as senior vice president, strategic product development where he was

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responsible for the company's product franchises in oncology, and cardiovascular, inflammatory, and metabolic diseases. Before Millennium, he served as director of molecular biology and director of market and business development at Biogen, Inc. ("Biogen"). At Biogen, Dr. Maraganore invented and led the discovery and development of ANGIOMAX® (bivalirudin) for injection, formerly HIRULOG™ and currently marketed by The Medicines Company. Prior to Biogen, Dr. Maraganore was a scientist at ZymoGenetics, Inc., and the Upjohn Company. Dr. Maraganore received his M.S. and Ph.D. in biochemistry and molecular biology at the University of Chicago. He is a member of the board of directors of Kymera Therapeutics, Takeda Pharmaceuticals, and Rapport Therapeutics, as well as a number of private companies. He is also a member of the board of the Biotechnology Innovation Organization (BIO), where he was Chair from 2017-2019. In addition, he serves in advisory roles for a number of investment and banking firms, including Arch Ventures, Atlas Ventures, Blackstone Life Sciences, Jefferies Financial Services, and RTW Investments. We believe that Dr. Maraganore's significant experience in executive roles in the biotechnology industry qualifies him to serve on our board of directors.

**Christi Shaw** has served on our board of directors since December 2023. Since January 2026, Ms. Shaw has served as the Executive Chairperson of Kyverna Therapeutics, Inc., a biotechnology company. Previously, Ms. Shaw served as the Chief Executive Officer of Kite, a Gilead company, specializing in the development of cancer immunotherapies from August 2019 to March 2023. From April 2017 to August 2019, Ms. Shaw served as Senior Vice President of Eli Lilly Company, a global healthcare company, and President of Lilly Bio-Medicines, the business within Eli Lilly Company that comprises neuroscience and immunology. From 2014 to 2016, Ms. Shaw served as U.S. country head and President of Novartis Pharmaceutical Corporation, a global healthcare company, and from 2010 to 2014 as North American region head of Novartis Oncology. Prior to 2010, Ms. Shaw held several leadership positions at Johnson & Johnson, Inc. Ms. Shaw previously served as a director of Avantor, Inc. Ms. Shaw is also the co-founder of the More Moments More Memories Foundation to assist people with cancer and their caregivers. Ms. Shaw holds a B.B.A. in Marketing from Iowa State University and an M.B.A. from the University of Wisconsin. We believe that Ms. Shaw is qualified to serve on our board of directors due to her significant experience in senior leadership in the biotechnology industry.

***Current Directors Not Standing for Election at the Annual Meeting***

**Graham Cooper** has served as a member of our board of directors since October 2019. Since December 2025, Mr. Cooper has been the Chief Financial Officer and Chief Operating Officer of Tavo Biotherapeutics, Inc., having previously served as its Chief Financial Officer since December 2024. From March 2018 until April 2019, Mr. Cooper served as the Chief Operating Officer and Chief Financial Officer of Assembly Biosciences, Inc. Mr. Cooper previously served as the Chief Financial Officer of Receptos, Inc., from February 2013 until its acquisition by Celgene in August 2015 and Chief Financial Officer of Geron Corporation from January 2012 to December 2012. From May 2006 until March 2011, Mr. Cooper served as Chief Financial Officer of Orexigen Therapeutics, Inc. Prior to that, Mr. Cooper held roles of increasing responsibility at Deutsche Bank Securities, an investment bank, from August 1997 to February 2006, including Director, Health Care Investment Banking. He began his career as an accountant at Deloitte & Touche and was previously a C.P.A. Mr. Cooper currently serves as chairman of the board of directors of Kezar Life Sciences, Inc. Mr. Cooper received a B.A. in Economics from the University of California at Berkeley and an M.B.A. from the Stanford Graduate School of Business. We believe that Mr. Cooper is qualified to serve on our board of directors due to his significant financial and accounting experience in the life sciences industry.

**Mark C. Fishman, M.D.**, has served on our board of directors since May 2018. Dr. Fishman is a Professor in the Harvard Department of Stem Cell and Regenerative Biology and Chief of the Pathways Clinical Service at Massachusetts General Hospital. In February 2019, he became a Co-Founding Partner of Aditum Bio Fund and Chairman of its Scientific and Medical Advisory Board. From 2002 through 2016, Dr. Fishman was the founding President of the Novartis Institutes for BioMedical Research (NIBR), a member of the Executive Committee of Novartis, AG, and served on the board of directors of Novartis International Pharmaceutical LTD and Chaired the board of directors of the Genomics Institute of the Novartis Research Foundation. Prior to his time at NIBR, he was the Founding Director of the Cardiovascular Research Center and Chief of Cardiology at Massachusetts General Hospital. Dr. Fishman also served as the Chairman of the board of directors of privately held Semma Therapeutics from 2016 until its sale to Vertex. He currently serves on the board of directors of the privately held companies EmbarkNeuro and Versanis Bio. He also serves as a consultant to and Scientific Advisory Board member of several other privately held biotechnology companies. Dr. Fishman graduated from Yale College and Harvard Medical School and trained in medicine and cardiology at Massachusetts General Hospital. We believe that Dr. Fishman's experience studying genetics and regenerative medicine makes him qualified to serve on our board of directors.

**Chirfi Guindo** has served on our board of directors since December 2024. Mr. Guindo has also served as the Chief Marketing Officer for Merck & Co., Inc. since July 2022. He is responsible for leading the development and implementation of Merck & Co.'s long-term strategy for the Human Health portfolio spanning oncology, vaccines, pharmaceutical and pipeline products. Prior to this role, Mr. Guindo served as the Executive Vice President of Global Product Strategy and Commercialization for Biogen Inc. from November 2018 to June 2022. Mr. Guindo graduated from Ecole Central de Paris (France) with a degree in engineering and has a master's of business administration from New York University's Stern School of Business. We believe that Mr. Guindo's extensive experience in executive roles in the biotechnology industry qualifies him to serve on our board of directors.

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**Kathleen E. Walsh** has served on our board of directors since January 2021. Ms. Walsh has served as Secretary of the Massachusetts Executive Office of Health and Human Services since January 2023. Prior to her appointment as Secretary, Ms. Walsh served as President and Chief Executive Officer of Boston Medical Center since March 2010, and as Executive Vice President and Chief Operating Officer of Brigham and Women's Hospital from 2005 to 2010. Prior to that, she served as the Chief Operating Officer for Novartis Institutes for Biomedical Research and at Massachusetts General Hospital in positions including Senior Vice President of Medical Services and at the MGH Cancer Center. Prior to that, she held hospital administrator positions in a number of New York City hospitals including Montefiore, Columbia Presbyterian Medical Center, Saint Luke's—Roosevelt Hospital Center and the New York City Health and Hospitals Corporation. Ms. Walsh is a member of the Boston Public Health Commission, the Massachusetts Hospital Association, Yale University, the Association of American Medical Colleges and the Pine Street Inn. Ms. Walsh served as a director of Navigant Consulting, Inc., a management consultancy firm, from 2017 to 2020, and served on its Audit Committee; WellCare Health Plans, Inc., a health insurance company, from 2017 to 2020, and served on its Audit Committee and IT Committee. Ms. Walsh holds a B.A. and Master of Public Health from Yale University. We believe that Ms. Walsh is qualified to serve on our board of directors based on her extensive experience in the health care industry.

**Board Diversity**

We believe that companies become more successful as they become more diverse. As we pursue future Board recruitment efforts, our nominating and corporate governance committee will therefore continue to seek out candidates who can contribute to the diversity of views and perspectives of our Board. This includes seeking out individuals of diverse gender identities, demographic backgrounds and perspectives informed by other personal and professional experiences.

**Board Leadership Structure** 

We do not currently have a chair of our Board; however, we have designated Dr. Mark Fishman as our lead independent director. We believe that appointing a lead independent director has the potential to allow our Chief Executive Officer to focus on our day-to-day business, while allowing Dr. Fishman to guide our Board in providing independent advice to and oversight of management. Our Board recognizes the time, effort and energy that our Chief Executive Officer is required to devote to his position and the importance of providing independent direction to our Board as its oversight responsibilities continue to grow. While our bylaws and corporate governance guidelines do not require that we appoint a chair of our Board or lead independent director, our Board believes that having a lead independent director provides the appropriate leadership structure for us and demonstrates our commitment to good corporate governance.

**Director Independence** 

Our Board currently consists of seven members. Our Board has determined that six of the currently serving seven members, Graham Cooper, Mark Fishman, M.D., Chirfi Guindo, John Maraganore, Ph.D., Christi Shaw and Kathleen Walsh, are independent directors in accordance with the listing requirements of The Nasdaq Stock Market ("Nasdaq"). Under the rules of Nasdaq, independent directors must comprise a majority of our Board. In addition, the rules of Nasdaq require that, subject to specified exceptions, each member of our audit and compensation committees be independent and that director nominees be selected or recommended for our Board's selection by independent directors constituting a majority of the independent directors or by a nominating and corporate governance committee comprised solely of independent directors. Under the rules of Nasdaq, a director will only qualify as "independent" if, in the opinion of our Board, that person does not have a relationship that would interfere with the exercise of independent judgment in carrying out the responsibilities of a director and that such person is "independent" as defined by the applicable rules of Nasdaq and the Securities Exchange Act of 1934, as amended (the "Exchange Act").

Audit committee members must also satisfy the independence criteria set forth in Rule 10A-3 under the Exchange Act. In order to be considered independent for purposes of Rule 10A-3, a member of our audit committee may not, other than in his or her capacity as a member of the audit committee, our Board or any other Board committee: (1) accept, directly or indirectly, any consulting, advisory or other compensatory fee from us or any of our subsidiaries or (2) be an affiliated person of us or any of our subsidiaries.

Based upon information requested from and provided by each director concerning his or her background, employment and affiliations, including family relationships, our Board has determined that each of our directors, with the exception of John Evans, our Chief Executive Officer, is an "independent director" as defined under applicable rules of Nasdaq, including, in the case of all the members of our audit committee, the independence criteria set forth in Rule 10A-3 under the Exchange Act, and in the case of all the members of our compensation committee, the independence criteria set forth in Rule 10C-1 under the Exchange Act. In making such determinations, our Board considered the relationships that each such non-employee director has with us and all other facts and circumstances that our Board deemed relevant in determining his or her independence, including the beneficial ownership of our capital stock by each non-employee director. John Evans is not an independent director under these rules because he is our Chief Executive Officer.

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**Role of Board in Risk Oversight Process** 

Our Board has an active role, as a whole and also at the committee level, in overseeing the management of our risks. Our Board is responsible for general oversight of risks and regular review of information regarding our risks, including credit risks, liquidity risks and operational risks. The compensation committee is responsible for overseeing the management of risks relating to our executive compensation plans and arrangements. The audit committee is responsible for overseeing the management of risks relating to accounting matters and financial reporting, legal and compliance risks, and cyber security risks. As part of this oversight, the audit committee receives regular reports from management on such risks at its regularly scheduled meetings, including reports not less than four times per year relating to data privacy and cyber security and the actions management has taken to limit, monitor or control such exposures. The nominating and corporate governance committee is responsible for overseeing the management of risks associated with the independence of our Board and potential conflicts of interest. Although each committee is responsible for evaluating certain risks and overseeing the management of such risks, the entire Board is regularly informed through discussions from committee members about such risks. Our Board believes its administration of its risk oversight function has not negatively affected our Board's leadership structure.

**Board Meetings and Attendance** 

Our Board held four meetings during the fiscal year ended December 31, 2025. Each of our directors attended at least seventy-five percent (75%) of the meetings of our Board and the committees of our Board on which he or she served during the fiscal year ended December 31, 2025 (in each case, which were held during the period for which he or she was a director and/or a member of the applicable committee and excluding any meetings in which a director was an interested party, if any). Our non-employee directors met in executive session during each of the regularly scheduled Board meetings during the fiscal year ended December 31, 2025.

While we do not have a formal policy regarding director attendance at our annual meeting of stockholders, we expect our Board members to prepare for, attend and participate in all Board and applicable committee meetings, including by means of remote communication. Seven of the eight directors who were then serving attended our 2025 annual meeting of stockholders.

**Board Committees**

Our Board has standing audit, compensation, and nominating and corporate governance committees, each of which is comprised solely of independent directors and is described more fully below. Our Board also currently has a science and technology committee. Each committee operates pursuant to a written charter, and each reviews and assesses the adequacy of its charter periodically and submits its charter to our Board for approval. The charter for each committee is available on our website (*www.beamtx.com*) under the "Investors—Corporate Governance" section. The information on our website is not a part of this proxy statement.

The following table describes which directors serve on each of our Board's committees.

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| | | | | |
|:---|:---|:---|:---|:---|
| **Name** | **Audit Committee** | **Compensation Committee** | **Nominating and Corporate<br>Governance Committee** | **Science and<br>Technology Committee** |
| Graham Cooper | Chair |  |  |  |
| Mark Fishman, M.D. |  |  | X | Chair |
| Chirfi Guindo |  | Chair |  |  |
| John Maraganore, Ph.D. |  |  | Chair | X |
| Christi Shaw | X |  | X |  |
| Kathleen Walsh | X | X |  |  |

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***Audit Committee*** 

Our audit committee's responsibilities include:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•appointing, approving the compensation of, and evaluating the qualifications, performance and independence of our independent registered public accounting firm;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•overseeing the work of our independent registered public accounting firm, including through the receipt and consideration of reports from such firm, and pre-approving all audit and permitted non-audit services to be performed by our independent registered public accounting firm;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•reviewing and discussing with management and our independent registered public accounting firm our annual and quarterly financial statements and related disclosures, including earnings releases;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•reviewing and discussing with management and our independent registered public accounting firm any material issues regarding accounting principles and financial statement presentations;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•coordinating our Board's oversight of our internal control over financial reporting, disclosure controls and procedures, code of business conduct and ethics, procedures for complaints and legal and regulatory matters;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•discussing our risk management policies with management;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•establishing policies regarding hiring employees from our independent registered public accounting firm and procedures for the receipt and retention of accounting related complaints and concerns;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•meeting independently with our independent registered public accounting firm and management;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•reviewing and approving any related person transactions;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•overseeing our guidelines and policies governing risk assessment and risk management, including with respect to cybersecurity and other information technology risks;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•overseeing the integrity of our information technology systems, processes and data;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•preparing the audit committee report required by SEC rules;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•reviewing and assessing, at least annually, the adequacy of the audit committee's charter; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•performing, at least annually, an evaluation of the performance of the audit committee.

All audit services and all permitted non-audit services, other than certain *de minimis* non-audit services that are approved by the audit committee prior to the completion of an audit, to be provided to us by our independent registered public accounting firm must be approved in advance by our audit committee.

The members of our audit committee are Graham Cooper, Christi Shaw and Kathleen Walsh. Mr. Cooper chairs the audit committee. Our Board has determined that each member of our audit committee satisfies the independence standards of the applicable rules of Nasdaq applicable to audit committee members and meets the independence criteria set forth in Rule 10A-3(b)(1) under the Exchange Act. Our Board has determined that each member of our audit committee has sufficient knowledge regarding fundamental financial statements to serve on the audit committee. Our Board has also determined that each of Mr. Cooper, Ms. Shaw and Ms. Walsh is an "audit committee financial expert," as defined under Item 407 of Regulation S-K.

During the fiscal year ended December 31, 2025, our audit committee met four times. The report of our audit committee is included in this proxy statement below under "Audit Committee Report."

***Compensation Committee*** 

Our compensation committee's responsibilities include:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•assisting our Board in developing and reviewing potential candidates for executive positions;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•reviewing our overall compensation strategy, including base salary, incentive compensation and equity-based grants;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•reviewing and approving corporate goals and objectives relevant to compensation of our Chief Executive Officer and our other executive officers;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•determining and approving, or recommending to our Board for approval, the compensation of our Chief Executive Officer and other executive officers;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•reviewing and making recommendations to our Board with respect to director compensation;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•overseeing and administering our cash and equity incentive plans;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•reviewing, considering and selecting, to the extent determined to be advisable, a peer group of appropriate companies for purposing of benchmarking and analysis of compensation for our executive officers and directors;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•reviewing and approving all employment contract and other compensation, severance and change-in-control arrangements for our executive officers;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•recommending to our Board any stock ownership guidelines for our executive officers and non-employee directors;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•retaining, appointing or obtaining advice of a compensation consultant, legal counsel or other advisor, and determining the compensation and independence of such consultant or advisor;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•preparing, if required, the compensation committee report on executive compensation for inclusion in our annual proxy statement in accordance with the proxy rules;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•monitoring our compliance with the requirements of Sarbanes-Oxley relating to loans to directors and officers;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•overseeing our compliance with applicable SEC rules regarding shareholder approval of certain executive compensation matters;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•reviewing the risks associated with our compensation policies and practices;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•reviewing and assessing, at least annually, the adequacy of the compensation committee's charter; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•performing, on an annual basis, an evaluation of the performance of the compensation committee.

The members of our compensation committee are Chirfi Guindo and Kathleen Walsh. Mr. Guindo chairs the compensation committee. Our Board has determined that each member of the compensation committee satisfies the independence standards of the applicable rules of Nasdaq applicable to compensation committee members and meets the independence criteria set forth in Rule 10C-1 under the Exchange Act. Our compensation committee may delegate any of the responsibilities of the full committee to subcommittees and may delegate certain responsibilities of the full committee to executive officers of the Company and other persons as may be permitted by applicable laws, rules or regulations and in accordance with the listing standards set forth by Nasdaq.

During the fiscal year ended December 31, 2025, our compensation committee met four times. The report of our compensation committee is included in this proxy statement below under "Compensation Committee Report."

***Nominating and Corporate Governance Committee*** 

Our nominating and corporate governance committee's responsibilities include:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•identifying individuals qualified to become members of our Board consistent with criteria approved by our Board and receiving nominations for such qualified individuals;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•recommending to our Board the persons to be nominated for election as directors and to each committee of our Board;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•establishing a policy under which our stockholders may recommend a candidate to our nominating and corporate governance committee for consideration for nomination as a director;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•reviewing and recommending committee slates on an annual basis;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•recommending to our Board qualified candidates to fill vacancies on our Board;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•developing and recommending to our Board a set of corporate governance principles applicable to us and reviewing the principles on at least an annual basis;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•reviewing and making recommendations to our Board with respect to our board leadership structure and board committee structure;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•reviewing, in concert with our Board, our policies with respect to significant issues of corporate public responsibility;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•making recommendations to our Board's processes for annual evaluations of the performance of our Board, our Chief Executive Officer and committees of our Board;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•overseeing the process for annual evaluations of our Board, Chief Executive Officer and committees of our Board and certifying that performance of our Chief Executive Officer and other members of executive management is being properly evaluated;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•considering and reporting to our Board any questions of possible conflicts of interest of members of our Board;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•providing new director orientation and continuing education for existing directors on a periodic basis;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•overseeing the maintenance and presentation to our Board of management's plans for succession to senior management positions in the Company;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•reviewing and assessing, at least annually, the adequacy of the nominating and corporate governance committee's charter; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•performing, on an annual basis, an evaluation of the performance of the nominating and corporate governance committee.

The members of our nominating and corporate governance committee are John Maraganore, Ph.D., Mark Fishman, M.D., and Christi Shaw. Dr. Maraganore chairs our nominating and corporate governance committee. Our Board has determined that each member of our nominating and corporate governance committee satisfies the independence standards of the applicable rules of Nasdaq.

During the fiscal year ended December 31, 2025, our nominating and corporate governance committee met three times.

**Compensation Committee Interlocks and Insider Participation**

None of the members of our compensation committee has at any time during the prior three years been one of our officers or employees. None of our executive officers currently serves, or in the past fiscal year has served, as a member of the board of directors or compensation committee of any entity that has one or more executive officers serving on our Board or compensation committee.

**Code of Business Conduct and Ethics**

We have adopted a written code of business conduct and ethics (the "Code") that applies to our directors, officers and employees, including our principal executive officer, principal financial officer, principal accounting officer or controller, or persons performing similar functions. A current copy of the Code is available on the investor section of our website at investors.beamtx.com. The information on our website is not a part of this proxy statement. We intend to disclose on our website any amendments to, or waivers from, our Code that are required to be disclosed pursuant to SEC rules.

**Clawback Policy**

Our Board has adopted a clawback policy in compliance with Nasdaq listing standards and Rule 10D-1 under the Exchange Act. The clawback policy provides that, in the event that we are required to prepare an accounting restatement for periods ending on or after October 2, 2023 (an "Accounting Restatement"), we will attempt to recover from our current or former executive officers (each, a "Covered Person"), on a pre-tax basis, any amount of incentive-based compensation that (a) exceeds the amount that otherwise would have been received had it been determined based on the restated financial statement amounts, and (b) was received during the three fiscal years preceding the determination that an Accounting Restatement was required (the "Recovery Period"), as further specified in the clawback policy. Further, if our compensation committee determines that a Covered Person's acts or omissions that contributed to the circumstances requiring an Accounting Restatement involved either (a) intentional misconduct or an intentional violation of any of our rules or any applicable legal or regulatory requirements in the course of the Covered Person's employment by us, or (b) fraud in the course of the Covered Person's employment by us, then we may attempt to recover from such Covered Person up to 100% of the Covered Person's incentive-based compensation and other equity awards or compensation other than base salary that was received by such Covered Person during the Recovery Period, as further specified in the clawback policy. For purposes of the clawback policy, incentive-based compensation means any compensation that is granted, earned or vested based wholly or in part upon the attainment

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of a financial reporting measure, as defined in the clawback policy. The clawback policy is overseen and administered by our compensation committee.

**Insider Trading Policy**

We have adopted an insider trading policy governing the purchase, sale and/or other dispositions of Company securities by our directors, NEOs, employees, designated consultants and other covered persons. We believe the insider trading policy is reasonably designed to promote compliance with insider trading laws, rules and regulations, and Nasdaq listing standards. A copy of our insider trading policy is filed as Exhibit 19.1 to our Annual Report on Form 10-K filed with the SEC on February 25, 2025.

Our insider trading policy prohibits covered persons from engaging in transactions of Company securities while aware of any material nonpublic information concerning the Company or disclosing material nonpublic information concerning the Company to any other person who may trade on the basis of that information, subject to certain limited exceptions described in the policy. In addition, the policy imposes quarterly blackout periods on certain covered persons and event-specific blackout periods on directors, NEOs and other specified employees who have knowledge of event-specific material nonpublic information. In addition, certain covered persons are required to obtain approval in advance of engaging in transactions in Company securities.

Certain transactions in our securities also create a heightened compliance risk or could create the appearance of misalignment between our employees, including our management, and stockholders. As a result, our insider trading policy expressly prohibits our directors, NEOs, employees, designated consultants and other covered persons, from engaging in speculative transactions in our stock, including buying our securities on margin, borrowing against our securities held in a margin account, engaging in short sales of our securities, and buying or selling derivatives on our securities and otherwise using financial instruments, such as prepaid variable forwards, equity swaps and exchange funds, to hedge or offset, or that are designed to hedge or offset, any decrease in the market value of our securities. Our insider trading policy also prohibits all of our employees, including our NEOs, and our directors from pledging our securities as collateral for a loan.

**Director Nomination Process** 

The process followed by our nominating and corporate governance committee to identify and evaluate director candidates includes requests to Board members and others for recommendations, meetings from time to time to evaluate biographical information and background material relating to current directors and potential candidates, and interviews of selected candidates by management, recruiters and members of the committee and our Board. In considering whether to recommend any particular candidate for inclusion in our Board's slate of recommended director nominees, including candidates recommended by stockholders, our nominating and corporate governance committee takes into account the criteria for membership on our Board as set forth in our corporate governance guidelines, including a candidate's ability, judgment and experience and the overall diversity and composition of our Board. We also value experience on other public company boards of directors and board committees. Our nominating and corporate governance committee does not have a policy (formal or informal) with respect to diversity, but takes into consideration each candidate's ability, judgment and experience to oversee our Company's business, and contribution to the overall diversity of our Board when recommending director nominees.

The biographies for the director nominees included herein indicate the nominees' experience, qualifications, attributes and skills that led our nominating and corporate governance committee and our Board to conclude such directors should continue to serve as directors of our Company. Our nominating and corporate governance committee and our Board believe that the nominees have the individual attributes and characteristics required of each of our directors.

Stockholders have the right under our bylaws to directly nominate director candidates for election at an annual meeting of stockholders, without any action or recommendation on the part of the nominating and corporate governance committee or our Board, by submitting to the Company their names, together with appropriate biographical information and background materials, a statement as to the number of shares of our common stock beneficially owned by the stockholder making the recommendation, and certain other information required by our bylaws. to: Beam Therapeutics Inc., 238 Main Street, Cambridge, MA 02142, Attention: Secretary. Assuming that appropriate biographical and background material has been provided on or before the dates set forth in this proxy statement under the heading "General Matters – Shareholder Proposals for our 2027 Annual Meeting of Stockholders", the nominating and corporate governance committee will evaluate stockholder-recommended candidates by following substantially the same process, and applying substantially the same criteria, as it follows for candidates submitted by others. If the Board determines to nominate a stockholder-recommended candidate and recommends his or her election, then his or her name will be included in our proxy card for the next annual meeting of stockholders.

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**Communication with Directors** 

Any stockholders or other interested parties desiring to communicate with our Board, or one or more of our directors, may send a letter addressed to the Board of Directors of Beam Therapeutics Inc., 238 Main Street, Cambridge, MA 02142. All such letters will be promptly forwarded to the appropriate members of our Board or individual directors, as applicable, by our Secretary. The mailing envelope should contain a clear notation that the enclosed letter is a "Stockholder-Board Communication" or "Stockholder-Director Communication." All such letters should clearly state whether the intended recipients are all members of our Board or certain specified individual directors.

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**EXECUTIVE OFFICERS**

Below is a list of the names, ages as of April 17, 2026 and positions, and a brief account of the business experience of the individuals who serve as our executive officers.

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| | | |
|:---|:---|:---|
| **Name** | **Age** | **Position** |
| John Evans | 48 | Chief Executive Officer and Director |
| Giuseppe Ciaramella, Ph.D. | 57 | President |
| Sravan K. Emany | 48 | Chief Financial Officer |
| Christine Bellon, Ph.D. | 61 | Chief Legal Officer and Secretary |
| Amy Simon, M.D. | 62 | Chief Medical Officer |

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**Executive Officer Biographies** 

The biographical information pertaining to Mr. Evans, who is a director and executive officer of our Company, is included under "Director Biographies," above.

***Giuseppe Ciaramella, Ph.D*.**, has served as our President since January 2020 and previously served as our Chief Scientific Officer from February 2018 to February 2023. Dr. Ciaramella has 25 years of drug discovery experience across different therapeutic modalities, from small molecule, to biologics, to advanced medicinal products, such as mRNA. From March 2022 to September 2024, Dr. Ciaramella served as interim Chief Executive Officer and a member of the board of directors of Orbital Therapeutics, Inc. Prior to joining Beam, Dr. Ciaramella was the Chief Scientific Officer of the Infectious Diseases division of Moderna Therapeutics from 2014 until February 2018, where he was instrumental in generating some of the first LNP-encapsulated, mRNA vaccines to be dosed in humans. From 2011 until 2014, Dr. Ciaramella served as Executive Director at AstraZeneca, where he led their small molecule antiviral strategy. Between 2010 and 2011 he served as Vice President and Head of Collaborative Research at Boehringer Ingelheim, where he had responsibility for external research. Prior to Boehringer Ingelheim, he spent 14 years at Pfizer in the U.K. where he held several leadership positions, including head of Biotherapeutics, head of Antivirals and head of the Hit Discovery Group. Dr. Ciaramella is a member of the Infectious Diseases Society of America and of the American Society of Gene Therapy. Dr. Ciaramella holds a Ph.D. in Biochemistry from University College London.

***Sravan K. Emany*** has served as our Chief Financial Officer since December 2024. Prior to joining Beam, Mr. Emany served as Chief Financial Officer and Chief Operating Officer of Ironwood Pharmaceuticals, Inc., a biotechnology company, from December 2021 to December 2024. Prior to that, Mr. Emany served as corporate vice president, commercial excellence and chief strategy officer of Integra LifeSciences Holdings Corporation, a publicly held global healthcare company, from March 2020 to December 2021, and as vice president of strategy, treasury and investor relations before that. Prior to Integra, Mr. Emany served in various mergers and acquisitions investment banking roles in Bank of America and BofA Securities, formerly Bank of America Merrill Lynch, for nearly a decade, culminating in his service as managing director in the mergers and acquisitions group, where he led numerous mergers and acquisitions in the healthcare sector. He also served in various other financial roles, including with Goldman Sachs Group and Morgan Stanley. Mr. Emany serves on the boards of directors of Assertio Holdings, Inc. and Kyverna Therapeutics, Inc. He holds a B.A. in international relations from The Johns Hopkins University and an M.A. in international relations and international economics from The Johns Hopkins School of Advanced International Studies.

***Christine Bellon, Ph.D., J.D.***, has served as our Chief Legal Officer since April 2019. Prior to joining Beam, she served as Senior Vice President, General Counsel and Corporate Secretary for Forma Therapeutics from October 2017 until April 2019. Prior to Forma, Dr. Bellon was Senior Vice President of Legal Affairs for Relay Therapeutics from July 2016 until October 2017. Prior to Relay, she served as Vice President of Legal Affairs and Corporate Secretary at Blueprint Medicines. Earlier in her career, Dr. Bellon practiced law and served in legal leadership roles at Hydra Biosciences and Infinity Pharmaceuticals. Dr. Bellon holds a B.S. in chemistry from Yale University; a Ph.D. in organic chemistry from the Massachusetts Institute of Technology, where she did research in the laboratory of K. Barry Sharpless; and a J.D. from Columbia Law School.

***Amy Simon, M.D.****,* has served as our Chief Medical Officer since March 2021. From April 2010 to March 2021, Dr. Simon worked at Alnylam Pharmaceuticals in roles with increasing responsibility for the clinical development of RNAi-based medicines, most recently as Vice President of Clinical Development. Previously, Dr. Simon served as a professor and a director of the Asthma Center in the Pulmonary and Critical Care Division at Tufts University School of Medicine and as a professor at Tufts Graduate School of Biomedical Science, where her laboratory conducted basic science research on asthma. She began her career in clinical practice, training as a resident in internal medicine and as a fellow in pulmonary and critical care medicine at Tufts Medical Center. Dr. Simon holds a B.A. in history and science from Harvard University, and an M.D. from Tufts University School of Medicine.

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**COMPENSATION DISCUSSION AND ANALYSIS**

The following Compensation Discussion and Analysis describes the philosophy, objectives and structure of our 2025 executive compensation program and includes discussion and background information regarding the compensation of our NEOs. This information is intended to be read in conjunction with the section titled "Executive Compensation" immediately following this section, which provide further historical compensation information.

Our NEOs for 2025 were:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•John Evans, our Chief Executive Officer ("CEO");

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Giuseppe Ciaramella, Ph.D., our President;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Sravan K. Emany, our Chief Financial Officer ("CFO");

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Christine Bellon, Ph.D., our Chief Legal Officer ("CLO"); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Amy Simon, M.D., our Chief Medical Officer ("CMO");

**Executive Summary**

***2025 Business Highlights***

We are committed to establishing the leading, fully integrated platform for precision genetic medicines. Our vision is to provide life-long cures to patients suffering from serious diseases. To achieve this vision, we have assembled a platform that includes a suite of gene editing and delivery technologies as well as internal manufacturing capabilities.

In 2025, we made significant progress toward achieving our vision:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•We disclosed positive initial safety and efficacy data in the Phase 1/2 clinical trial of BEAM-302 for the treatment of alpha-1 antitrypsin deficiency, with additional positive results from the trial announced in March 2026;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•We completed a $500 million oversubscribed, registered direct financing in connection with the release of our positive initial BEAM-302 data;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•We presented additional positive results from the BEACON Phase 1/2 clinical trial of risto-cel for the treatment of sickle cell disease at the 67th American Society of Hematology Annual Meeting and Exposition; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•We dosed initial patients in the clinical trial for BEAM-301 for the treatment of glycogen storage disease type 1a, and in the healthy volunteer study for BEAM-103, the monoclonal antibody intended to enable our ESCAPE program.

***Compensation Program Overview***

The fundamental philosophy of our executive compensation program set by our compensation committee is pay for performance. We have also designed our compensation program to balance performance-based compensation over the short and long term to incentivize decisions and actions that promote stockholder value and focus our executives on performance that benefits our stockholders, while discouraging inappropriate risk-taking behaviors. As described in more detail below, key elements of our compensation program include the following fixed and variable compensation elements:

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| | | |
|:---|:---|:---|
| **Compensation Elements** | **Purpose** | **Features** |
| ***Base Salary*** | To attract, motivate and retain superior executive talent with stable financial compensation. | Fixed component of pay based on responsibilities, experience, individual contributions and peer company data. |
| ***Annual Performance-<br>Based Cash Bonus*** | To reward the achievement of annual performance goals that directly correlate to the enhancement of stockholder value, as well as to facilitate executive retention. | Variable component of pay based on annual quantitative and qualitative achievement of corporate business objectives. |

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| | | |
|:---|:---|:---|
| ***Long-Term Equity Incentives*** | To motivate and retain executives to achieve multi-year strategic goals while aligning their interests with those of stockholders through long-term incentives linked to value creation. | Long-term variable compensation incentive in the form of stock options and restricted stock units ("RSUs"). |

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In addition to our direct compensation elements, the following features of our compensation program are designed to align with stockholder interests and best practices, achieve our compensation philosophy and support our business goals:

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| | | | |
|:---|:---|:---|:---|
|  | **What We Do** |  | **What We Don't Do** |
| ☑ | Align compensation with performance | ☒ | Guarantee salary increases, bonuses, or equity awards |
| ☑ | Compensate primarily through variable, at-risk incentive pay  | ☒  | Provide excessive severance payments |
| ☑ | Set challenging corporate performance goals | ☒  | Provide excessive perquisites |
| ☑ | Consult with an independent compensation advisor on compensation levels and practices | ☒  | Provide tax gross-up payments for any change-in-control payments |
| ☑ | Maintain a compensation committee with independent directors | ☒  | Stock option re-pricings without shareholder approval |
| ☑  | Use an industry-specific peer group tailored to current market capitalization and stage of development and verifiable market data to determine competitive pay | ☒  | Supplemental executive retirement plans |
| ☑  | Set challenging short- and long-term incentive program goals |  |  |
| ☑  | Responsibly use shares under our long-term incentive program |  |  |
| ☑  | Grant equity awards with meaningful vesting periods |  |  |
| ☑  | Maintain an executive compensation clawback policy |  |  |
| ☑ | Provide market-competitive benefits for executives which are consistent with the rest of our employees |  |  |
| ☑ | Maintain robust anti-hedging and anti-pledging policies |  |  |

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**Compensation Philosophy and Objectives** 

Our compensation committee believes a well-designed compensation program should align executive interests with stockholder interests by supporting achievement of our primary business goals, as well as the attraction and retention of employees whose talents, expertise, leadership and contributions are expected to sustain growth in long-term stockholder value. Consequently, we are committed to a strong performance orientation in our compensation program. Our compensation committee regularly reviews our compensation practices to ensure that they are aligned with the interests of our stockholders and our business goals, and that the total compensation paid to our employees and directors is fair, reasonable and competitive.

We make gradual changes to our executive compensation program to adopt practices that are appropriate for our status as a publicly traded company as well as changes in our business and industry. Our compensation committee and Board believe it appropriate to continue to fine tune our executive compensation program but generally have avoided dramatic changes since we became a publicly traded company. Consistent with good governance practices, we work with our independent compensation consultant to regularly review and update our executive compensation program.

**Compensation Determination Process**

***Role of the Compensation Committee and Board of Directors***

Our compensation committee is responsible for overseeing the total compensation of our executive officers. In this capacity, our compensation committee designs, implements, determines and approves all compensation for our executive officers. The compensation committee reports to our Board regarding discussions and approvals related to executive compensation matters, seeking input from our Board as appropriate. Board compensation is assessed by the compensation committee and recommendations for changes to Board compensation are recommended to our full Board for approval. The compensation committee's recommendations regarding executive compensation are based on the committee's assessment of Company performance and the performance of each individual executive officer, as well as other factors, such as prevailing industry trends and the competitive market for executive talent.

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***Role of Management***

Our CEO and Chief Human Resources Officer ("CHRO") routinely make recommendations to our compensation committee, attend certain compensation committee meetings and are involved in the process for determining our executive officers' compensation. Our CEO does not make recommendations as to his own compensation or participate in compensation committee discussion regarding his compensation. The compensation committee reviews the recommendations from our CEO and CHRO, in conjunction with data and recommendations provided by the committee's independent compensation consultant. The compensation committee then considers these recommendations and may adjust compensation up or down as it determines to be appropriate. The compensation committee will then approve, or make recommendations to our Board to approve, each executive officer's total compensation, including the individual pay component.

***Use of Independent Compensation Consultant***

Our compensation committee is authorized to retain the services of one or more compensation consultants in connection with the establishment of our executive compensation programs and related policies. For 2025, our compensation committee engaged Pay Governance LLC ("Pay Governance") as its independent compensation consultant to advise on executive compensation matters, including overall compensation program design, peer group development and updates, and collecting market data to inform our compensation programs for our executives and members of our Board.

We develop our compensation programs after reviewing publicly available compensation data, and we also subscribe to various global annual and specialized life sciences and general industry surveys on an ongoing basis. Our compensation committee has the authority to select, retain and terminate our compensation consultants, as well as to approve any fees, terms or other conditions of their service. Compensation consultants regularly attend meetings of our compensation committee and report directly to our compensation committee and not to management. When directed to do so by our compensation committee, our compensation consultants also work collaboratively with Company management, including our CEO and CHRO, to develop analyses and proposals for presentations to our compensation committee. Our compensation committee reviews the performance of our independent consultants on an annual basis and determines whether to continue the engagement. Our compensation committee has assessed the independence of Pay Governance consistent with SEC rules and Nasdaq listing standards and has concluded that the engagement of Pay Governance did not raise any conflicts of interest that would prevent this consultant from independently advising our compensation committee.

***Compensation-Setting Factors***

Our compensation committee considers the factors outlined below when determining and approving both target and actual compensation for our NEOs:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•our performance against the annual corporate goals established by our compensation committee in consultation with our CEO and CHRO;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•each NEO's skills, experience and qualifications relative to other similarly-situated executives at the companies in our compensation peer group;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•the scope of each NEO's role compared to other similarly-situated executives at the companies in our compensation peer group;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•the performance of each NEO, based on an assessment of his or her contributions to our overall performance, ability to lead his or her department and work as part of a team, all of which reflect our values;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•compensation parity among our executive officers;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•our retention goals;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•the compensation practices of companies within our compensation peer group;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•the results of our stockholders' advisory "say-on-pay" votes; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•our CEO's and CHRO's recommendations with respect to the compensation of our other executive officers.

These factors provide the framework for compensation decisions for each of our NEOs. Our compensation committee does not assign relative weights or rankings to these factors and does not consider any single factor as determinative when making compensation decisions for our executive officers. Rather, our compensation committee believes it is best to rely on their own knowledge of our business and industry and therefore they use judgment in assessing each of these factors and making compensation decisions.

***Say-on-Pay Vote Results***

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At our 2025 annual meeting of stockholders, we conducted a non-binding advisory vote on the compensation of our NEOs as disclosed in our 2025 proxy statement, commonly referred to as a "say-on-pay" vote. We received substantial support for our compensation practices, with approximately 99% of the votes cast on this proposal cast in favor of the compensation paid to our NEOs. Our compensation committee and Board take the "say-on-pay" voting results into account in determining the compensation of our NEOs. Our compensation committee and Board believe that the strong level of support evidenced by last year's "say on pay" vote indicates that the design of our current executive compensation program is aligned with what stockholders believe will create long-term stockholder value. Accordingly, the compensation committee decided to maintain our general approach to executive compensation in 2026, in part, as a result of the 2025 "say-on-pay" vote. Our compensation committee and Board will continue to consider stockholder input and proactively monitor our compensation program to ensure it continues to align the interests of our NEOs with the interests of our stockholders.

***Use of a Peer Group***

Our compensation committee approves a peer group of companies as a reference to provide a broad perspective on competitive pay levels and practices within our industry. The peers are reviewed on an annual basis in light of the fast-moving changes in our business and our industry. We undertake this review with the assistance and recommendations of our compensation consultant.

In September 2024, our compensation committee approved a peer group for use in making 2025 compensation decisions. Our compensation committee used the following guidelines in determining the appropriate peers:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•companies whose industry, therapeutic focus, number of employees, stage of development and market capitalization are similar, though not necessarily identical, to ours;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•companies against which we believe that we compete with for executive talent; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•public companies based in the United States whose compensation and financial data are available in proxy statements or through widely available compensation surveys.

Our peer group for 2025 was comprised of the following companies:

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| | | |
|:---|:---|:---|
| Agios Pharmaceuticals, Inc. | CRISPR Therapeutics AG | Iovance Biotherapeutics, Inc. |
| Apellis Pharmaceuticals, Inc. | Denali Therapeutics Inc. | Prime Medicine, Inc. |
| Arcellx, Inc. | Editas Medicine, Inc. | Rocket Pharmaceuticals, Inc. |
| Arrowhead Pharmaceuticals, Inc. | ImmunityBio, Inc. | Sana Biotechnology, Inc. |
| Blueprint Medicines Corporation | Intellia Therapeutics, Inc. | Verve Therapeutics, Inc. |
| BridgeBio Pharma Inc. |  |  |

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We set target cash and equity compensation after reviewing the compensation paid to executives within our compensation peer group and considering other market information. We target cash and equity compensation for our executives to be aligned with executives in our compensation peer group; however, our own performance and the individual performance of our executive officers informs decisions on compensation. In setting actual compensation levels, our compensation committee considers the executive's experience, performance levels, existing equity holdings and market factors as deemed appropriate.

**Pay Components**

***Base Salary***

We use base salaries to recognize the experience, skills, knowledge and responsibilities required of all our employees, including our NEOs. None of our NEOs are currently party to an employment agreement or other agreement or arrangement that provides for automatic or scheduled increases in base salary. On an annual basis, our compensation committee reviews and evaluates the need for adjustment of the base salaries of our executive officers based on, among other things, changes and expected changes in the scope of an executive officer's responsibilities, including promotions, the individual contributions made by and performance of the executive officer during the prior year, our overall growth and development as a company and general salary or other market trends in our industry.

In November 2024, our compensation committee approved salary increases for each of our then-serving NEOs based on a review of market data provided by Pay Governance, the current compensation levels of our NEOs and our performance against our 2024 corporate performance goals. The table below sets forth the adjustments to base salary, in dollars, for each of our NEOs serving in 2025:

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| | | | |
|:---|:---|:---|:---|
| **Name** | **2024 Base Salary<br>($)** | **2025 Base Salary <br>($)** | **Increase <br>(%)** |
| John Evans | 715750 | 755000 | 5.5 |
| Giuseppe Ciaramella, Ph.D. | 642500 | 668000 | 4.0 |
| Sravan K. Emany | 575000 | 575000 | 0 |
| Christine Bellon, Ph.D. | 491000 | 510500 | 4.0 |
| Amy Simon, M.D. | 517500 | 550000 | 6.3 |

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***Annual Performance-Based Cash Bonuses***

Our Board has adopted a cash incentive plan that provides for cash bonus payments to eligible executives based upon the attainment of corporate performance goals established by our compensation committee for the company prior to or during the first quarter of the applicable fiscal year. We believe this bonus plan provides incentives that motivate and reward achievement of performance goals that directly correlate to enhancement of stockholder value, consistent with our compensation philosophy. Each executive officer who is selected to participate in the cash incentive plan has a target award opportunity set for each performance period. We do not establish threshold or maximum payments under our bonus plan, as our compensation committee believes it is appropriate to retain discretion in determining bonus amounts.

Our performance goals vary from year to year. For 2025, these included:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•clinical goals to advance key programs toward patient dosing, positive clinical trial results and regulatory clearance;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•research goals to advance numerous programs in our early-stage pipeline;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•manufacturing goals to ensure efficient patient supply of investigational drug product;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•commercial goals for organizational build, regulatory filing readiness, and go-to-market strategies;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•organizational goals to attract and retain high performing talent; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•financial goals to extend our cash runway and manage our operating expenses.

Our compensation committee and our Board review our achievement of the performance goals in their totality, considering our overall performance for the year, and come to a general, subjective conclusion as to whether the performance goals were met, and whether there were any other extraordinary factors that should be considered in determining the amount of bonus earned for the year. Our compensation committee and our Board believe that maintaining discretion to evaluate corporate performance at the close of the year based on the totality of the circumstances, and the discretion to award or fail to award bonus compensation without reliance on rote calculations under set formulas is appropriate in responsibly discharging their duties.

Based on our strong corporate performance in 2025 in relation to our goals, our compensation committee determined that all of our employees, including our NEOs, would receive bonuses in the amount of 135% of their targets. The cash incentive plan payments for each of our NEOs for 2025 were as shown in the table below.

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| | | | |
|:---|:---|:---|:---|
| **Name** | **Target Award <br>(% of Base Salary)** | **2025 Target Cash Incentive Payment<br>($)** | **2025 Actual Cash Incentive Payment<br>($)** |
| John Evans | 65% | 490750 | 662513 |
| Giuseppe Ciaramella, Ph.D. | 55% | 367400 | 495990 |
| Sravan K. Emany | 50% | 287500 | 388125 |
| Christine Bellon, Ph.D. | 45% | 229725 | 310129 |
| Amy Simon, M.D. | 45% | 247500 | 334125 |

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***Long-Term Equity Incentives***

We believe that equity grants provide our executives with a strong link to our long-term performance, create an ownership culture and help align the interests of our executives and our stockholders. In addition, we believe that equity grants with a time-based vesting feature promote executive retention. We use stock options and RSUs to compensate our executive officers in the form of initial grants in connection with the commencement of employment and on an annual basis as our executive officers continue their employment. We generally grant a combination of stock options and RSUs at a fixed ratio of two option shares for each RSU. Our compensation

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committee structured the mix of equity vehicles and the relative weight assigned to each type of award to motivate stock price appreciation over the long term through stock options, which deliver value only if the stock price increases, and to ensure some amount of value delivery through the RSUs, which are complementary because they have upside potential but deliver some value even during periods of stock price or market underperformance, while also reinforcing an ownership culture and commitment to us. In deciding to incorporate RSUs into our equity incentive compensation program, our compensation committee considered a host of factors, including annual long-term incentive values, annual equity awards expressed as a percent of total shares outstanding, total annual and cumulative dilution, the retentive value of outstanding awards, total equity ownership and the equity compensation practices of other companies in our industry that compete with us for talent.

In determining the size of the equity awards granted to our NEOs, our compensation committee, with assistance from our compensation consultant, considers our company performance, individual performance, the potential for enhancing the creation of value for our stockholders, our broader organizational equity needs and overall dilution, as well as industry and peer group practices. We evaluate our equity award program on an annual basis to ensure that it appropriately links to our long-term performance by aligning the interests of our executives and our stockholders, remains competitive with industry and peer practices and is consistent with our overall equity needs and dilution levels.

In 2025, our compensation committee approved the grant of stock options and RSUs to our NEOs in the amounts set forth in the table below.

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| | | | |
|:---|:---|:---|:---|
| **Name** | **Option Award <br>(# shares)** | **RSU Award <br>(# shares)** | **Grant Date Fair Value of Option and RSU Awards<br>($)**<sup>(1)</sup> |
| John Evans<sup>(2)</sup> | 155000 | 77500 | 4390329 |
| Giuseppe Ciaramella, Ph.D.<sup>(2)</sup> | 70000 | 35000 | 1982729 |
| Sravan K. Emany<sup>(3)</sup> |  |  |  |
| Christine Bellon, Ph.D.<sup>(2)</sup> | 40000 | 20000 | 1132988 |
| Amy Simon, M.D.<sup>(4)</sup> | 55000 | 40000 | 1904359 |

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<sup>(1)</sup> These amounts represent the aggregate grant date fair value of option awards and RSU awards, computed in accordance with the rules of the Financial Accounting Standards Board Accounting Standards Codification Topic 718 ("FASB ASC 718"), excluding the effect of estimated forfeitures. The assumptions used to value the awards granted for this purpose are set forth in Note 12, *Stock option and grant plan*, to our audited financial statements filed with our Annual Report on Form 10-K for the fiscal year ended December 31, 2025.

<sup>(2)</sup> Consists of stock option awards granted in January 2025 and RSU awards granted in March 2025.

<sup>(3)</sup> Mr. Emany did not receive any equity awards in 2025 because he commenced employment with us in December 2024.

<sup>(4)</sup> Consists of stock option awards granted in January 2025 and RSU awards granted in March 2025 and December 2025.

***Severance and Change in Control Benefits***

As discussed under "Executive Compensation" below, we offer our executives severance benefits in connection with certain termination events, as well as benefits in connection with change-in-control situations, as we believe such compensation protections are appropriate in light of similar benefits available to executive officers at companies in our compensation peer group. We believe that reasonable and competitive change-in-control payments and benefits are an important part of an executive compensation program to attract and retain senior executives. We also believe such payments and benefits are in the best interests of our stockholders because they incentivize senior executives to achieve stockholder value in connection with change-in-control situations, particularly where the possibility of a change-in-control and the related uncertainty may otherwise lead to the departure or distraction of senior executives to the detriment of our company and our stockholders.

***Other Compensation Policies and Practices***

*Health and Welfare Benefits*

Our NEOs are eligible to participate in all of our employee benefit plans, including our medical, dental, vision, life and disability insurance plans and commuting benefits plan, in each case, on the same basis as our other full-time employees. We believe that these competitive health and welfare benefits help ensure that we have a productive and focused workforce.

*401(k) Plan*

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We maintain a tax-qualified 401(k) defined contribution plan that is intended to qualify under Section 401(k) of the Internal Revenue Service Code of 1986, as amended, and any regulations promulgated thereunder (the "Internal Revenue Code"). In general, all of our full-time employees, including our NEOs, are eligible to participate in our 401(k) plan. Our 401(k) plan includes a salary deferral arrangement pursuant to which participants may elect to reduce a portion of their current compensation by up to the statutorily prescribed limit and have the amount of the reduction contributed to the 401(k) plan. We provide an employer matching contribution equal to 50% of a participant's eligible contributions of up to 6% of eligible compensation, subject to certain limits established by the Internal Revenue Code. Our matching contributions are 100% vested when made. Matching contributions made to each of our NEOs are included in the "Executive Compensation—Summary Compensation Table" below. Our 401(k) plan is intended to provide our employees, including our NEOs, with an opportunity for tax-efficient retirement savings and long-term financial security. We do not maintain any defined benefit pension plans, non-qualified deferred compensation plans or other special or supplemental executive retirement programs.

*Employee Stock Purchase Plan* 

Pursuant to our employee stock purchase plan, our full-time employees, including our NEOs, have an opportunity to purchase our common stock at a discount on a tax-preferred basis through payroll deductions. Our employee stock purchase plan is designed to qualify as an "employee stock purchase plan" under Section 423 of the Internal Revenue Code. The purpose of our employee stock purchase plan is to encourage our full-time employees, including our NEOs, to become our stockholders and better align their interests with those of our other stockholders.

*Perquisites*

We do not view perquisites or other personal benefits as a significant component of our executive compensation program. We currently, and may in the future, provide perquisites to our NEOs in situations where we believe it is appropriate to assist an individual in the performance of his or her duties, to make him or her more efficient and effective, and for recruitment and retention purposes.

*No Change-in-Control Tax Gross-ups*

We do not provide for any tax gross-up payments to our NEOs in connection with changes-in-control.

*Accounting and Tax Considerations*

We account for equity compensation paid to our employees under FASB ACS 718, which requires us to estimate and record an expense over the service period of any such award. Accounting rules also require us to record cash compensation as an expense at the time the obligation is accrued. To date, these accounting requirements have not impacted our executive compensation programs and practices.

While our compensation committee generally considers the tax implications to us of its executive compensation decisions, neither element was a material consideration in the compensation awarded to our NEOs in 2025. Section 162(m) of the Internal Revenue Code generally disallows a tax deduction to public companies for compensation in excess of $1 million paid in any one year to each of certain of the company's current and former executive officers.

**Compensation Risk Assessment**

Our compensation committee believes that our executive compensation program does not encourage excessive or unnecessary risk taking and, as a result, does not believe that our compensation programs are reasonably likely to have a material adverse effect on us. In reaching these conclusions, our compensation committee considered various factors, including the following:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•We offer executives a competitive base salary, which we believe mitigates risk-taking behavior by providing reasonable predictability in the base level of income earned by each executive and alleviating pressure on executives to focus solely on our near-term stock price performance or annual bonus awards to the detriment of building long-term stockholder value.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•We use a mixture of compensation elements intended to be competitive with those offered to similarly-situated executives at comparable companies within our industry, with significant weighting towards long-term incentive compensation, which has retention value and discourages short-term risk taking.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Our performance goals for our annual cash bonus awards reflect a balanced mix of performance objectives, to avoid excessive weight on any one goal or performance measure and are intended to be challenging yet attainable, which mitigates the potential that our executives will take excessive risks.

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•To minimize the risk of certain transactions related to our securities, our insider trading policy prohibits all of our employees, including our executive officers, and our directors from engaging in speculative transactions in our stock, including hedging or similar arrangements, put or call options, short sales, pledges and margin purchases related to our stock.

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**COMPENSATION COMMITTEE REPORT**

*The information contained in this report shall not be deemed to be "soliciting material" or "filed" or incorporated by reference in future filings with the SEC, or subject to the liabilities of Section 18 of the Exchange Act, except to the extent that we specifically incorporate it by reference into a document filed under the Securities Act or the Exchange Act.* 

Our compensation committee has reviewed and discussed the "Compensation Discussion and Analysis" section of this proxy statement with management. Based on the review and discussions, our compensation committee recommended to our Board that the "Compensation Discussion and Analysis" section be included in this proxy statement, which is incorporated by reference in our Annual Report on Form 10-K for the fiscal year ended December 31, 2025.

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| |
|:---|
| Members of the Compensation Committee |
| Chirfi Guindo (Chair) |
| Kathleen Walsh |

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**EXECUTIVE COMPENSATION**

This section provides an overview of the compensation awarded to, earned by or paid to our NEOs.

**Summary Compensation Table**

The following table sets forth the compensation provided to our NEOs for the fiscal years ended December 31, 2025, December 31, 2024 and December 31, 2023, respectively.

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| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| **Name and Principal Position** | **Year** | **Salary<br>($)** | **Bonus**<sup>(1)</sup>**<br>($)** | **Stock<br>Awards**<sup>(2)</sup>**<br>($)** | **Option<br>Awards**<sup>(3)</sup>**<br>($)** | **Non-Equity<br>Incentive Plan<br>Compensati-on**<sup>(4)</sup>**<br>($)** | **All Other<br>Compensatio-n**<sup>(5)</sup>**<br>($)** | **Total<br>($)** |
| John Evans | 2025 | 755000 |  | 1513575 | 2876754 | 662513 | 10684 | 5818525 |
| &nbsp;&nbsp;&nbsp;&nbsp;*CEO* | 2024 | 715750 |  | 2560600 | 2615021 | 515340 | 2920 | 6409631 |
|  | 2023 | 685000 |  | 1722375 | 3423499 | 431550 | 17675 | 6280099 |
| Giuseppe Ciaramella, Ph.D. | 2025 | 668000 |  | 683550 | 1299179 | 495990 | 13560 | 3160279 |
| &nbsp;&nbsp;&nbsp;&nbsp;*President* | 2024 | 642500 |  | 1156400 | 1180977 | 385500 | 13270 | 3378647 |
|  | 2023 | 615000 |  | 612400 | 1217244 | 322875 | 17675 | 2785194 |
| Sravan K. Emany | 2025 | 575000 | 325000 |  |  | 388125 | 8403 | 1296528 |
| &nbsp;&nbsp;&nbsp;&nbsp;*CFO* | 2024 | 19904 |  | 1984000 | 2814352 |  | 50 | 4818306 |
| Christine Bellon, Ph.D. | 2025 | 510500 |  | 390600 | 742388 | 310129 | 13560 | 1967177 |
| &nbsp;&nbsp;&nbsp;&nbsp;*CLO* | 2024 | 491000 |  | 908600 | 927911 | 235680 | 18270 | 2581460 |
|  | 2023 | 470000 |  | 535850 | 1065089 | 197400 | 12675 | 2281014 |
| Amy Simon, M.D. | 2025 | 550000 |  | 883575 | 1020784 | 334125 | 13560 | 2802044 |
| &nbsp;&nbsp;&nbsp;&nbsp;*CMO* | 2024 | 517500 |  | 908600 | 927911 | 248400 | 13270 | 2615681 |
|  | 2023 | 495000 |  | 612400 | 1217244 | 207900 | 12675 | 2545219 |

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<sup>(1)</sup> Consists of a signing bonus paid to Mr. Emany in January 2025.

<sup>(2)</sup> The amounts reflect the grant date fair value of RSUs granted during the applicable year, computed in accordance with FASB ASC 718, excluding the effect of estimated forfeitures. The assumptions used to value the RSUs granted in 2025 for this purpose are set forth in Note 12, *Stock option and grant plan*, to our audited financial statements filed with our Annual Report on Form 10-K for the fiscal year ended December 31, 2025.

<sup>(3)</sup> The amounts reported in this column represent the aggregate grant date fair value of options to purchase shares of our common stock granted during the applicable fiscal year, computed in accordance with FASB ASC 718, excluding the effect of estimated forfeitures. The assumptions used to value the options granted in fiscal years 2023, 2024 and 2025 for this purpose are set forth in Note 12, *Stock option and grant plan*, to our audited financial statements filed with our Annual Report on Form 10-K for the fiscal year ended December 31, 2025.

<sup>(4)</sup> Amounts shown represent each NEO's annual bonus earned under the Beam Therapeutics Inc. 2019 Cash Incentive Plan based on the attainment of corporate performance goals.

<sup>(5)</sup> The amount reported for Mr. Evans for fiscal year 2025 consists of 401(k) matching contributions ($7,624), commuting benefits ($1,860) and a cell phone allowance ($1,200). The amount reported for Dr. Ciaramella for fiscal year 2025 consists of 401(k) matching contributions ($10,500), commuting benefits ($1,860) and a cell phone allowance ($1,200). The amount reported for Mr. Emany for fiscal year 2025 consists of 401(k) matching contributions ($7,203) and a cell phone allowance ($1,200). The amount reported for Dr. Bellon for fiscal year 2025 consists of 401(k) matching contributions ($10,500), commuting benefits ($1,860) and a cell phone allowance ($1,200). The amount reported for Dr. Simon for fiscal year 2025 consists of 401(k) matching contributions ($10,500), commuting benefits ($1,860) and a cell phone allowance ($1,200).

**Agreements with our NEOs**

------

Each of our NEOs is party to an amended and restated employment or letter agreement with us that sets forth the terms and conditions of his or her employment. The material terms of the agreements are described below. The terms "cause," "good reason" and "change in control" referred to below are defined in each respective NEO's agreement.

***Mr. Evans****.* Our amended and restated letter agreement with Mr. Evans provides for a fixed base salary and annual bonus, subject to periodic review and adjustment by our compensation committee, with the actual amount of the bonus earned based on the terms of the applicable bonus plan developed by our Board or compensation committee. The letter agreement also provides that, for so long as Mr. Evans serves as our CEO, we will nominate him to serve as a member of our Board at each annual meeting of our stockholders at which his then-current term expires, and, if so elected at such meeting, he will continue to serve as a member of our Board. Mr. Evans' amended and restated letter agreement contains a perpetual confidentiality covenant and an assignment of intellectual property covenant. Mr. Evans is also party to an Employee Non-Competition, Non-Solicitation, Confidentiality and Assignment Agreement under which he has agreed not to compete with us or solicit our employees, consultants, customers or suppliers during his employment and for one year following his termination of employment and has agreed to a perpetual confidentiality covenant and an assignment of intellectual property covenant.

***Dr. Ciaramella*.** Our amended and restated employment agreement with Dr. Ciaramella provides for a fixed base salary and annual bonus, subject to periodic review and adjustment by our compensation committee, with the actual amount of the bonus earned based on the terms of the applicable bonus plan developed by our Board or compensation committee. Dr. Ciaramella's amended and restated employment agreement contains a perpetual confidentiality covenant and an assignment of intellectual property covenant. Dr. Ciaramella is also party to an Employee Non-Competition, Non-Solicitation, Confidentiality and Assignment Agreement under which he has agreed not to compete with us or solicit our employees, consultants, customers or suppliers during his employment and for one year following his termination of employment and has agreed to a perpetual confidentiality covenant and an assignment of intellectual property covenant.

***Mr. Emany*.** Our letter agreement with Mr. Emany provides for a fixed base salary and annual bonus, subject to periodic review and adjustment by our compensation committee, with the actual amount of the bonus earned based on the terms of the applicable bonus plan developed by our Board or compensation committee. Mr. Emany is also party to an Employee Non-Solicitation, Confidentiality and Assignment Agreement under which he has agreed not to solicit our employees, independent contractors, customers, vendors or suppliers during his employment and for one year following his termination of employment and has agreed to a perpetual confidentiality covenant and an assignment of intellectual property covenant.

***Dr. Bellon*.** Our amended and restated letter agreement with Dr. Bellon provides for a fixed base salary and annual bonus, subject to periodic review and adjustment by our compensation committee, with the actual amount of the bonus earned based on the terms of the applicable bonus plan developed by our Board or compensation committee. Dr. Bellon is also party to an Employee Non-Solicitation, Confidentiality and Assignment Agreement under which she has agreed not to solicit our employees, independent contractors, customers, vendors or suppliers during her employment and for one year following her termination of employment and has agreed to a perpetual confidentiality covenant and an assignment of intellectual property covenant.

***Dr. Simon*.** Our amended and restated letter agreement with Dr. Simon provides for a fixed base salary and annual bonus, subject to periodic review and adjustment by our compensation committee, with the actual amount of the bonus earned based on the terms of the applicable bonus plan developed by our Board or compensation committee. Dr. Simon is also party to an Employee Non-Solicitation, Confidentiality and Assignment Agreement under which she has agreed not to solicit our employees, independent contractors, customers, vendors or suppliers during her employment and for one year following her termination of employment and has agreed to a perpetual confidentiality covenant and an assignment of intellectual property covenant.

**Pay Ratio Disclosure**

As required by Section 953(b) of the Dodd-Frank Wall Street Reform and Consumer Protection Act and Item 402(u) of Regulation S-K, we are providing the ratio of the annual total compensation of the individual identified as our paid median employee to the annual total compensation of our principal executive officer. The paragraphs that follow describe our methodology and the resulting pay ratio.

We identified a median employee using our employee population as of December 31, 2025 based on base pay during 2025 and target cash bonus during 2025. We did not make any cost-of-living adjustments or adjustments for part-time employees to calculate what they would have been paid on a full-time basis, nor did we annualize compensation. Once the median employee was identified, we calculated the median employee's annual total compensation in the same method used to calculate and report our principal executive officer's compensation.

------

The total compensation for 2025 for our median employee, identified as discussed above, was $264,185. Our principal executive officer's compensation as reported in the Summary Compensation Table was $5,818,525. Therefore, our pay ratio is approximately 22 to one.

The pay ratio reported above is a reasonable estimate calculated in a manner consistent with SEC rules based on our internal records and the methodology described above. The SEC rules for identifying the median compensated employee and calculating the pay ratio based on that employee's annual total compensation allow companies to adopt a variety of methodologies, to apply certain exclusions, and to make reasonable estimates and assumptions that reflect their employee populations and compensation practices. Therefore, the pay ratio reported by other companies may not be comparable to the pay ratio reported above, as other companies have different employee populations and compensation practices and may utilize different methodologies, exclusions, estimates and assumptions in calculating their own pay ratios.

**Grants of Plan-Based Awards**

The following table shows information regarding grants of plan-based awards to our NEOs during the fiscal year ended December 31, 2025.

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| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| **Name** | **Grant Date** | **Date of Committee Approval** | **Estimated Future Payouts Under Non-Equity Incentive Plan Awards**<sup>(1)</sup> | **All Other Stock Awards: Number of Shares of Stock or Units <br>(#)** | **All Other Option Awards: Number of Securities Underlying Options <br>(#)** | **Exercise or Base Price of Option Awards**<sup>(2)</sup>**<br>($)** | **Grant Date Fair Value of Stock and Option Awards**<sup>(3)</sup>**<br>($)** |
|  |  |  | **Target<br>($)** |  |  |  |  |
| John Evans |  |  | 490750 |  |  |  |  |
|  | 1/31/2025 | 11/25/2024 |  |  | 155000 | 25.92 | 2876754 |
|  | 3/31/2025 | 11/25/2024 |  | 77500 |  |  | 1513575 |
| Sravan K. Emany |  |  |  |  |  |  |  |
| Giuseppe Ciaramella, Ph.D. |  |  | 367400 |  |  |  |  |
|  | 1/31/2025 | 11/25/2024 |  |  | 70000 | 25.92 | 1299179 |
|  | 3/31/2025 | 11/25/2024 |  | 35000 |  |  | 683550 |
| Christine Bellon, Ph.D. |  |  | 229725 |  |  |  |  |
|  | 1/31/2025 | 11/25/2024 |  |  | 40000 | 25.92 | 742388 |
|  | 3/31/2025 | 11/25/2024 |  | 20000 |  |  | 390600 |
| Amy Simon, M.D. |  |  | 247500 |  |  |  |  |
|  | 1/31/2025 | 11/25/2024 |  |  | 55000 | 25.92 | 1020784 |
|  | 3/31/2025 | 11/25/2024 |  | 27500 |  |  | 537075 |
|  | 12/31/2025 | 12/9/2025 |  | 12500 |  |  | 346500 |

---

<sup>(1)</sup> Amounts shown in the "Target ($)" column reflect the target amount payable to each NEO under our annual cash incentive program as described under "*Compensation Discussion and Analysis—Annual Performance-Based Cash Bonuses*" above. Actual payments made for 2025 are provided in the "Summary Compensation Table" above. As there are no threshold amounts and no maximum amounts with respect to these performance-based cash payments, the columns "Threshold ($)" and "Maximum ($)" are inapplicable and therefore have been omitted from this table. Each award was made pursuant to our 2019 Cash Bonus Plan.

<sup>(2)</sup> The exercise price of these stock options is equal to the per share closing price of our common stock as reported on the Nasdaq Global Select Market on the grant date.

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<sup>(3)</sup> These amounts represent the aggregate grant date fair value of awards in 2025, computed in accordance with FASB ASC 718, excluding the effect of estimated forfeitures. The assumptions used to value the awards granted for this purpose are set forth in Note 12, *Stock option and grant plan*, to our audited financial statements filed with our Annual Report on Form 10-K for the fiscal year ended December 31, 2025. Each award was made pursuant to our 2019 Equity Incentive Plan.

**Outstanding Awards at Fiscal Year-End**

The following table sets forth information concerning outstanding equity awards held by our NEOs as of December 31, 2025.

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| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
|  | **Option Awards** | **Option Awards** | **Option Awards** | **Option Awards** | **Option Awards** | **Stock Awards** | **Stock Awards** |
| **Name** | **Number of<br>Securities<br>Underlying<br>Unexercised<br>Options <br>Exercisable<br>(#)** | **Number of<br>Securities<br>Underlying<br>Unexercised<br>Options<br>Unexercisable<br>(#)** | **Equity <br>Incentive<br>Plan Awards:<br>Number of<br>Securities<br>Underlying<br>Unexercised<br>Unearned<br>Options<br>(#)** | **Option<br>Exercise<br>Price<br>($/share)** | **Option<br>Expiration<br>Date** | **Number<br>of Shares<br>of Stock<br>That Have<br>Not Vested<br>(#)** | **Market Value<br>of Shares of<br>Stock That<br>Have Not<br>Vested**<sup>(1)</sup>**<br>($)** |
| John Evans |  |  |  |  |  | 14063<br><sup>(2)</sup> | 389826 |
|  |  |  |  |  |  | 28125<br><sup>(3)</sup> | 779625 |
|  |  |  |  |  |  | 58125<br><sup>(4)</sup> | 1611225 |
|  |  |  |  |  |  | 77500<br><sup>(5)</sup> | 2148300 |
|  | 118672 |  |  | 0.67 | 5/8/2028<br><sup>(6)</sup> |  |  |
|  | 237141 |  |  | 1.03 | 7/13/2028<br><sup>(7)</sup> |  |  |
|  | 107929 |  |  | 4.22 | 2/13/2029<br><sup>(8)</sup> |  |  |
|  | 196904 |  |  | 7.22 | 5/17/2029<br><sup>(9)</sup> |  |  |
|  | 138750 |  |  | 80.04 | 3/31/2031<br><sup>(10)</sup> |  |  |
|  | 110156 | 2344 |  | 69.21 | 1/31/2032<br><sup>(11)</sup> |  |  |
|  | 82031 | 30469 |  | 43.45 | 1/31/2033<br><sup>(12)</sup> |  |  |
|  | 74270 | 80730 |  | 24.40 | 1/31/2034<br><sup>(13)</sup> |  |  |
|  | 35520 | 119480 |  | 25.92 | 1/31/2035<br><sup>(14)</sup> |  |  |
| Giuseppe Ciaramella, Ph.D. |  |  |  |  |  | 3750<br><sup>(15)</sup> | 103950 |
|  |  |  |  |  |  | 10000<br><sup>(16)</sup> | 277200 |
|  |  |  |  |  |  | 26250<br><sup>(17)</sup> | 727650 |
|  |  |  |  |  |  | 35000<br><sup>(18)</sup> | 970200 |
|  | 6505 |  |  | 0.67 | 5/8/2028<br><sup>(19)</sup> |  |  |
|  | 85946 |  |  | 1.03 | 7/13/2028<br><sup>(20)</sup> |  |  |
|  | 19002 |  |  | 7.22 | 5/17/2029<br><sup>(21)</sup> |  |  |
|  | 432313 |  |  | 17.00 | 2/5/2030<br><sup>(22)</sup> |  |  |
|  | 50000 |  |  | 80.04 | 3/31/2031<br><sup>(23)</sup> |  |  |
|  | 29375 | 625 |  | 69.21 | 1/31/2032<br><sup>(24)</sup> |  |  |
|  | 29166 | 10834 |  | 43.45 | 1/31/2033<br><sup>(25)</sup> |  |  |
|  | 33541 | 36459 |  | 24.40 | 1/31/2034<br><sup>(26)</sup> |  |  |
|  | 16041 | 53959 |  | 25.92 | 1/31/2035<br><sup>(27)</sup> |  |  |
| Sravan K. Emany |  |  |  |  |  | 60000<br><sup>(28)</sup> | 1663200 |
|  |  |  |  | 24.80 | 12/31/2034<br><sup>(29)</sup> | 120000 |  |
| Christine Bellon, Ph.D. |  |  |  |  |  | 3750<br><sup>(30)</sup> | 103950 |
|  |  |  |  |  |  | 8750<br><sup>(31)</sup> | 242550 |
|  |  |  |  |  |  | 20625<br><sup>(32)</sup> | 571725 |
|  |  |  |  |  |  | 20000<br><sup>(33)</sup> | 554400 |
|  |  |  |  | 7.22 | 5/16/2029<br><sup>(34)</sup> |  |  |
|  | 10410 |  |  | 7.22 | 5/17/2029<br><sup>(35)</sup> |  |  |
|  | 23959 |  |  | 80.04 | 3/31/2031<br><sup>(36)</sup> |  |  |
|  | 10000 | 1563 |  | 110.92 | 8/31/2031<br><sup>(37)</sup> |  |  |
|  | 29375 | 1667 |  | 69.21 | 1/31/2032<br><sup>(38)</sup> |  |  |
|  | 25000 | 8125 |  | 39.11 | 12/30/2032<br><sup>(39)</sup> |  |  |
|  | 25520 | 8334 |  | 43.45 | 1/31/2033<br><sup>(40)</sup> |  |  |
|  | 26354 | 18230 |  | 24.40 | 1/31/2034<br><sup>(41)</sup> |  |  |
|  | 9166 | 42396 |  | 25.92 | 1/31/2035<br><sup>(42)</sup> |  |  |
| Amy Simon, M.D. |  |  |  |  |  | 3750<br><sup>(43)</sup> | 103950 |

---

------

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
|  |  |  |  | 1250 | <sup>(44)</sup> | 34650 |
|  |  |  |  | 10000 | <sup>(45)</sup> | 277200 |
|  |  |  |  | 20625 | <sup>(46)</sup> | 571725 |
|  |  |  |  | 27500 | <sup>(47)</sup> | 762300 |
|  |  |  |  | 12500 | <sup>(48)</sup> | 346500 |
| 79500 |  | 80.04 | 3/31/2031<br><sup>(49)</sup> |  |  |  |
| 29375 | 625 | 69.21 | 1/31/2032<br><sup>(50)</sup> |  |  |  |
| 8750 | 1250 | 38.71 | 6/30/2032<br><sup>(51)</sup> |  |  |  |
| 29166 | 10834 | 43.45 | 1/31/2033<br><sup>(52)</sup> |  |  |  |
| 26354 | 28646 | 24.40 | 1/31/2034<br><sup>(53)</sup> |  |  |  |
| 12604 | 42396 | 25.92 | 1/31/2035<br><sup>(54)</sup> |  |  |  |

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<sup>(1)</sup> Based on the per share closing price of a share of our common stock on the Nasdaq Global Select Market on December 31, 2025 ($27.72).

<sup>(2)</sup> Represents 56,250 RSUs, each representing the right to receive one share of our common stock, granted on March 31, 2022, which vest in equal annual installments on the first four anniversaries of the grant date, generally subject to Mr. Evans' continued employment with us through the applicable vesting date.

<sup>(3)</sup> Represents 56,250 RSUs, each representing the right to receive one share of our common stock, granted on March 31, 2023, which vest in equal annual installments on the first four anniversaries of the grant date, generally subject to Mr. Evans' continued employment with us through the applicable vesting date.

<sup>(4)</sup> Represents 77,500 RSUs, each representing the right to receive one share of our common stock, granted on March 31, 2024, which vest in equal annual installments on the first four anniversaries of the grant date, generally subject to Mr. Evans' continued employment with us through the applicable vesting date.

<sup>(5)</sup> Represents 77,500 RSUs, each representing the right to receive one share of our common stock, granted on March 31, 2025, which vest in equal annual installments on the first four anniversaries of the grant date, generally subject to Mr. Evans' continued employment with us through the applicable vesting date.

<sup>(6)</sup> Represents an option to purchase 198,672 shares of our common stock granted on May 8, 2018, which vested as to 50% of the underlying shares upon the achievement of certain development milestones related to gene editing applications and as to 50% of the underlying shares upon the achievement of a closing price hurdle following our IPO.

<sup>(7)</sup> Represents an option to purchase 539,645 shares of our common stock granted on July 13, 2018, which vested as to 25% of the underlying shares on January 8, 2019 and in 36 equal monthly installments thereafter.

<sup>(8)</sup> Represents an option to purchase 107,929 shares of our common stock granted on February 13, 2019, which vested as to 50% of the underlying shares upon the achievement of certain development milestones related to gene editing applications and as to 50% of the underlying shares upon the achievement of a closing price hurdle following our IPO.

<sup>(9)</sup> Represents an option to purchase 223,000 shares of our common stock granted on May 17, 2019, which vested as to 25% of the underlying shares on October 1, 2020 and in 36 equal monthly installments thereafter.

<sup>(10)</sup> Represents an option to purchase 138,750 shares of our common stock granted on March 31, 2021, which vested in 48 equal monthly installments.

<sup>(11)</sup> Represents an option to purchase 112,500 shares of our common stock granted on January 31, 2022, which vests in 48 equal monthly installments, generally subject to Mr. Evans' continued employment with us through the applicable vesting date.

<sup>(12)</sup> Represents an option to purchase 112,500 shares of our common stock granted on January 31, 2023, which vests in 48 equal monthly installments, generally subject to Mr. Evans' continued employment with us through the applicable vesting date.

<sup>(13)</sup> Represents an option to purchase 155,000 shares of our common stock granted on January 31, 2024, which vests in 48 equal monthly installments, generally subject to Mr. Evans' continued employment with us through the applicable vesting date.

<sup>(14)</sup> Represents an option to purchase 155,000 shares of our common stock granted on January 31, 2025, which vests in 48 equal monthly installments, generally subject to Mr. Evans' continued employment with us through the applicable vesting date.

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<sup>(15)</sup> Represents 15,000 RSUs, each representing the right to receive one share of our common stock, granted on March 31, 2022, which vest in equal annual installments on the first four anniversaries of the grant date, generally subject to Dr. Ciaramella's continued employment with us through the applicable vesting date.

<sup>(16)</sup> Represents 20,000 RSUs, each representing the right to receive one share of our common stock, granted on March 31, 2023, which vest in equal annual installments on the first four anniversaries of the grant date, generally subject to Dr. Ciaramella's continued employment with us through the applicable vesting date.

<sup>(17)</sup> Represents 35,000 RSUs, each representing the right to receive one share of our common stock, granted on March 31, 2024, which vest in equal annual installments on the first four anniversaries of the grant date, generally subject to Dr. Ciaramella's continued employment with us through the applicable vesting date.

<sup>(18)</sup> Represents 35,000 RSUs, each representing the right to receive one share of our common stock, granted on March 31, 2025, which vest in equal annual installments on the first four anniversaries of the grant date, generally subject to Dr. Ciaramella's continued employment with us through the applicable vesting date.

<sup>(19)</sup> Represents an option to purchase 273,175 shares of our common stock granted on May 8, 2018, which vested as to 25% of the underlying shares on February 26, 2019 and in 36 equal monthly installments thereafter.

<sup>(20)</sup> Represents an option to purchase 129,788 shares of our common stock granted on July 13, 2018, which vested as to 25% of the underlying shares on February 26, 2019 and in 36 equal monthly installments thereafter.

<sup>(21)</sup> Represents an option to purchase 121,646 shares of our common stock granted on May 17, 2019, which vested as to 25% of the underlying shares on October 1, 2020 and in 36 equal monthly installments thereafter.

<sup>(22)</sup> Represents an option to purchase 510,893 shares of our common stock granted on February 5, 2020, which vested as to 25% of the underlying shares on February 5, 2021 and in 36 equal monthly installments thereafter..

<sup>(23)</sup> Represents an option to purchase 50,000 shares of our common stock granted on March 31, 2021, which vested in 48 equal monthly installments.

<sup>(24)</sup> Represents an option to purchase 30,000 shares of our common stock granted on January 31, 2022, which vests in 48 equal monthly installments, generally subject to Dr. Ciaramella's continued employment with us through the applicable vesting date.

<sup>(25)</sup> Represents an option to purchase 40,000 shares of our common stock granted on January 31, 2023, which vests in 48 equal monthly installments, generally subject to Dr. Ciaramella's continued employment with us through the applicable vesting date.

<sup>(26)</sup> Represents an option to purchase 70,000 shares of our common stock granted on January 31, 2024, which vests in 48 equal monthly installments, generally subject to Dr. Ciaramella's continued employment with us through the applicable vesting date.

<sup>(27)</sup> Represents an option to purchase 70,000 shares of our common stock granted on January 31, 2025, which vests in 48 equal monthly installments, generally subject to Dr. Ciaramella's continued employment with us through the applicable vesting date.

<sup>(28)</sup> Represents 80,000 RSUs, each representing the right to receive one share of our common stock, granted on December 31, 2024, which vest in equal annual installments on the first four anniversaries of the grant date, generally subject to Mr. Emany's continued employment with us through the applicable vesting date.

<sup>(29)</sup> Represents an option to purchase 160,000 shares of our common stock granted on December 31, 2024, which vested as to 25% of the underlying shares on December 31, 2025 and vests in 36 equal monthly installments thereafter, generally subject to Mr. Emany's continued employment with us through the applicable vesting date.

<sup>(30)</sup> Represents 15,000 RSUs, each representing the right to receive one share of our common stock, granted on March 31, 2022, which vest in equal annual installments on the first four anniversaries of the grant date, generally subject to Dr. Bellon's continued employment with us through the applicable vesting date.

<sup>(31)</sup> Represents 17,500 RSUs, each representing the right to receive one share of our common stock, granted on March 31, 2023, which vest in equal annual installments on the first four anniversaries of the grant date, generally subject to Dr. Bellon's continued employment with us through the applicable vesting date.

<sup>(32)</sup> Represents 27,500 RSUs, each representing the right to receive one share of our common stock, granted on March 31, 2024, which vest in equal annual installments on the first four anniversaries of the grant date, generally subject to Dr. Bellon's continued employment with us through the applicable vesting date.

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<sup>(33)</sup> Represents 20,000 RSUs, each representing the right to receive one share of our common stock, granted on March 31, 2025, which vest in equal annual installments on the first four anniversaries of the grant date, generally subject to Dr. Bellon's continued employment with us through the applicable vesting date.

<sup>(34)</sup> Represents an option to purchase 100,350 shares of our common stock granted on May 16, 2019, which vested as to 25% of the underlying shares on the first anniversary and at a rate of 2.78% each month until fully vested.

<sup>(35)</sup> Represents an option to purchase 100,350 shares of our common stock granted on May 17, 2019, which vested as to 25% of the underlying shares on the first anniversary and at a rate of 2.78% each month until fully vested.

<sup>(36)</sup> Represents an option to purchase 25,000 shares of our common stock granted on March 31, 2021, which vested at a rate of 2.08% each month until fully vested.

<sup>(37)</sup> Represents an option to purchase 10,000 shares of our common stock granted on August 31, 2021, which vested at a rate of 2.08% each month until fully vested.

<sup>(38)</sup> Represents an option to purchase 30,000 shares of our common stock granted on January 31, 2022, which vests at a rate of 2.08% each month until fully vested, generally subject to Dr. Bellon's continued employment with us through the applicable vesting date.

<sup>(39)</sup> Represents an option to purchase 25,000 shares of our common stock granted on December 30, 2022, which vests at a rate of 2.78% each month until fully vested, generally subject to Dr. Bellon's continued employment with us through the applicable vesting date.

<sup>(40)</sup> Represents an option to purchase 35,000 shares of our common stock granted on January 31, 2023, which vests at a rate of 2.08% each month until fully vested, generally subject to Dr. Bellon's continued employment with us through the applicable vesting date.

<sup>(41)</sup> Represents an option to purchase 55,000 shares of our common stock granted on January 31, 2024, which vests at a rate of 2.08% each month until fully vested, generally subject to Dr. Bellon's continued employment with us through the applicable vesting date.

<sup>(42)</sup> Represents an option to purchase 40,000 shares of our common stock granted on January 31, 2025, which vests in 48 equal monthly installments, generally subject to Dr. Bellon's continued employment with us through the applicable vesting date.

<sup>(43)</sup> Represents 15,000 RSUs, each representing the right to receive one share of our common stock, granted on March 31, 2022, which vest in equal annual installments on the first four anniversaries of the grant date, generally subject to Dr. Simon's continued employment with us through the applicable vesting date.

<sup>(44)</sup> Represents 5,000 RSUs, each representing the right to receive one share of our common stock, granted on June 30, 2022, which vest in equal annual installments on the first four anniversaries of the grant date, generally subject to Dr. Simon's continued employment with us through the applicable vesting date.

<sup>(45)</sup> Represents 20,000 RSUs, each representing the right to receive one share of our common stock, granted on March 31, 2023, which vest in equal annual installments on the first four anniversaries of the grant date, generally subject to Dr. Simon's continued employment with us through the applicable vesting date.

<sup>(46)</sup> Represents 27,500 RSUs, each representing the right to receive one share of our common stock, granted on March 31, 2024, which vest in equal annual installments on the first four anniversaries of the grant date, generally subject to Dr. Simon's continued employment with us through the applicable vesting date.

<sup>(47)</sup> Represents 27,500 RSUs, each representing the right to receive one share of our common stock, granted on March 31, 2025, which vest in equal annual installments on the first four anniversaries of the grant date, generally subject to Dr. Simon's continued employment with us through the applicable vesting date.

<sup>(48)</sup> Represents 12,500 RSUs, each representing the right to receive one share of our common stock granted on December 31, 2025, which vest in equal annual installments on the first four anniversaries of the grant date, generally subject to Dr. Simon's continued employment with us through the applicable vesting date.

<sup>(49)</sup> Represents an option to purchase 79,500 shares of our common stock granted on March 31, 2021, which vested as to 25% of the underlying shares on the first anniversary of the grant date and at a rate of 2.78% each month until fully vested.

<sup>(50)</sup> Represents an option to purchase 30,000 shares of our common stock granted on January 31, 2022, which vests at a rate of 2.08% each month until fully vested, generally subject to Dr. Simon's continued employment with us through the applicable vesting date.

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<sup>(51)</sup> Represents an option to purchase 10,000 shares of our common stock granted on June 30, 2022, which vests at a rate of 2.08% each month until fully vested, generally subject to Dr. Simon's continued employment with us through the applicable vesting date.

<sup>(52)</sup> Represents an option to purchase 40,000 shares of our common stock granted on January 31, 2023, which vests at a rate of 2.08% each month until fully vested, generally subject to Dr. Simon's continued employment with us through the applicable vesting date.

<sup>(53)</sup> Represents an option to purchase 55,000 shares of our common stock granted on January 31, 2024, which vests at a rate of 2.08% each month until fully vested, generally subject to Dr. Simon's continued employment with us through the applicable vesting date.

<sup>(54)</sup> Represents an option to purchase 55,000 shares of our common stock granted on January 31, 2025, which vests in 48 equal monthly installments, generally subject to Dr. Simon's continued employment with us through the applicable vesting date.

**Options Exercised and Stock Vested**

The following table sets forth, for each of our NEOs, information with respect to the exercise of stock options or vesting of stock awards during the fiscal year ended December 31, 2025.

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| | | | | |
|:---|:---|:---|:---|:---|
|  | **Option Awards** | **Option Awards** | **Stock Awards** | **Stock Awards** |
| **Name** | **Number of Shares Acquired on Exercise <br>(#)** | **Value Realized on Exercise**<sup>(1)</sup> **<br>($)** | **Number of Shares Acquired on Vesting**<sup>(2)</sup>**<br>(#)** | **Value Realized on Vesting**<sup>(3)</sup>**<br>($)** |
| John Evans | 80000 | 1977207 | 64844 | 1266403 |
| Giuseppe Ciaramella, Ph.D. |  |  | 23750 | 463838 |
| Sravan K. Emany |  |  | 20000 | 554400 |
| Christine Bellon, Ph.D. | 10000 | 267800 | 23542 | 499828 |
| Amy Simon, M.D. |  |  | 31813 | 618158 |

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<sup>(1)</sup> The value realized upon the exercise of stock option awards does not represent proceeds from any sale of any common stock acquired upon exercise but is determined by multiplying the number of shares acquired upon exercise by the difference between the per share exercise price of the option and the per share closing price of our common stock on the Nasdaq Global Select Market on each day of exercise.

<sup>(2)</sup> Represents RSUs that vested during fiscal year 2025.

<sup>(3)</sup> The value realized upon vesting of restricted stock is calculated by multiplying the number of shares of restricted stock vested by the per share closing price of our common stock on the Nasdaq Global Select Market on the applicable vest date.

**Policies and Practices Related to the Grant of Certain Equity Awards** 

We grant equity awards, including stock options and RSUs, to our employees and directors on an annual basis. We also grant equity awards to individuals upon hire or promotion or for retention purposes, or upon appointment to our Board. We currently do not grant stock appreciation rights or similar option-like instruments. During the last fiscal year, neither the Board nor the compensation committee took material nonpublic information into account when determining the timing or terms of stock options, nor did the Company time the disclosure of material nonpublic information for the purpose of affecting the value of executive compensation.

Under our equity award grant policy, we generally grant stock options only on pre-determined dates. Our annual equity award grants to employees are generally approved at a meeting of the compensation committee that is held during the fourth quarter. The stock option grants are effective on January 31, and the RSU grants are effective on March 31. Off-cycle stock option grants for new hires and promotions are made at the end of the month of hire or promotion. Our annual stock option grants to directors are automatically effective on the date of our annual meeting of stockholders. During fiscal 2025, we did not grant stock options, stock appreciation rights or similar option-like instruments to any NEO during any period beginning four business days before and ending one business day after the filing of any Form 10-Q or Form 10-K, or the filing or furnishing of a Form 8-K that disclosed material nonpublic information.

**Severance Upon Termination of Employment; Change in Control**

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***Mr. Evans.*** Under his amended and restated letter agreement, if Mr. Evans's employment is terminated by us without cause or by him for good reason, he will be entitled to receive (i) continued payment of his base salary for a period of 12 months, (ii) an amount equal to his target annual bonus for the year of termination, pro-rated to reflect the portion of the calendar year during which he was employed, (iii) continued vesting for 12 months of any unvested equity awards, (iv) extended exercisability of the options granted to him on May 8, 2018 and July 13, 2018 until the earlier of the expiration of the original term and the date that is 24 months following his termination and (v) payment of his full COBRA premiums for 12 months following his termination (or, if earlier, until the date on which Mr. Evans becomes eligible for coverage under a subsequent employer's medical plan), subject to his eligibility for, and timely election of, COBRA coverage.

In the event of a change in control, any unvested equity awards held by Mr. Evans, other than the portion of such equity awards that would otherwise have vested during the six-month period following such change in control (referred to as the "carved-out equity"), will become fully vested and exercisable. The carved-out equity will remain outstanding and eligible to vest in accordance with its terms. Under his amended and restated letter agreement, if Mr. Evans's employment is terminated by us without cause or by him for good reason within 12 months following or within 30 days immediately prior to the change in control, he will be entitled to receive (i) continued payment of his base salary for a period of 18 months following termination, (ii) an amount equal to 1.5 multiplied by his target annual bonus for the year of termination, (iii) immediate vesting of any unvested equity awards, (iv) extended exercisability of the options granted to him on May 8, 2018 and July 13, 2018 until the earlier of the expiration of the original term and the date that is 24 months following his termination and (v) payment of his full COBRA premiums for 18 months following his termination (or, if earlier, until the date on which Mr. Evans becomes eligible for coverage under a subsequent employer's medical plan), subject to his eligibility for, and timely election of, COBRA coverage.

***Dr. Ciaramella*.** Under his amended and restated employment agreement, if Dr. Ciaramella's employment is terminated by us without cause or by him for good reason, he will be entitled to receive (i) continued payment of his base salary for a period of 12 months, (ii) an amount equal to his target annual bonus for the year of termination, pro-rated to reflect the portion of the calendar year during which he was employed, (iii) continued vesting for 12 months of any unvested equity awards and (iv) payment of his full COBRA premiums for 12 months following his termination (or, if earlier, until the date on which Dr. Ciaramella becomes eligible for coverage under a subsequent employer's medical plan), subject to his eligibility for, and timely election of, COBRA coverage.

In the event of a change in control, 50% of the unvested equity awards held by Dr. Ciaramella, other than the portion of such equity awards that would otherwise have vested during the six-month period following such change in control (referred to as the "carved-out equity"), will become fully vested and exercisable. The carved-out equity will remain outstanding and eligible to vest in accordance with its terms. Under his amended and restated employment agreement, if Dr. Ciaramella's employment is terminated by us without cause or by him for good reason within 12 months following or within 30 days immediately prior to the change in control, he will be entitled to receive (i) continued payment of his base salary for a period of 12 months, (ii) an amount equal to his target annual bonus for the year of termination, (iii) immediate vesting of any unvested equity awards and (iv) payment of his full COBRA premiums for 12 months following his termination (or, if earlier, until the date on which Dr. Ciaramella becomes eligible for coverage under a subsequent employer's medical plan), subject to his eligibility for, and timely election of, COBRA coverage.

***Mr. Emany*.** Under his letter agreement, if Mr. Emany's employment is terminated by us without cause, he will be entitled to receive (i) continued payment of his base salary for a period of 12 months and (ii) payment of a portion of his COBRA premiums for 12 months following his termination (or, if earlier, until the date on which Mr. Emany becomes eligible for coverage under a subsequent employer's medical plan) in an amount equal to the employer portion of such premiums for active employees, subject to his eligibility for, and timely election of, COBRA coverage.

Under his letter agreement, if Mr. Emany's employment is terminated by us without cause or by him for good reason within 12 months following or within 30 days immediately prior to a change in control, he will be entitled to receive (i) continued payment of his base salary for a period of 12 months following termination, (ii) an amount equal to his target annual bonus for the year of termination, (iii) immediate vesting of any unvested equity awards and (iv) payment of a portion of his COBRA premiums for 12 months (or, if earlier, until the date on which Mr. Emany becomes eligible for coverage under a subsequent employer's medical plan) in an amount equal to the employer portion of such premiums for active employees, subject to his eligibility for, and timely election of, COBRA coverage.

***Dr. Bellon*.** Under her amended and restated letter agreement, if Dr. Bellon's employment is terminated by us without cause, she will be entitled to receive (i) continued payment of her base salary for a period of 12 months and (ii) payment of a portion of her COBRA premiums for 12 months following her termination (or, if earlier, until the date on which Dr. Bellon becomes eligible for coverage under a subsequent employer's medical plan) in an amount equal to the employer portion of such premiums for active employees, subject to her eligibility for, and timely election of, COBRA coverage.

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Under her amended and restated letter agreement, if Dr. Bellon's employment is terminated by us without cause or by her for good reason within 12 months following or within 30 days immediately prior to a change in control, she will be entitled to receive (i) continued payment of her base salary for a period of 12 months following termination, (ii) an amount equal to her target annual bonus for the year of termination, (iii) immediate vesting of any unvested equity awards and (iv) payment of a portion of her COBRA premiums for 12 months (or, if earlier, until the date on which Dr. Bellon becomes eligible for coverage under a subsequent employer's medical plan) in an amount equal to the employer portion of such premiums for active employees, subject to her eligibility for, and timely election of, COBRA coverage.

***Dr. Simon*.** Under her amended and restated letter agreement, if Dr. Simon's employment is terminated by us without cause, she will be entitled to receive (i) continued payment of her base salary for a period of 12 months and (ii) payment of a portion of her COBRA premiums for 12 months following her termination (or, if earlier, until the date on which Dr. Simon becomes eligible for coverage under a subsequent employer's medical plan) in an amount equal to the employer portion of such premiums for active employees, subject to her eligibility for, and timely election of, COBRA coverage.

Under her amended and restated letter agreement, if Dr. Simon's employment is terminated by us without cause or by her for good reason within 12 months following or within 30 days immediately prior to a change in control, she will be entitled to receive (i) continued payment of her base salary for a period of 12 months following termination, (ii) an amount equal to her target annual bonus for the year of termination, (iii) immediate vesting of any unvested equity awards and (iv) payment of a portion of her COBRA premiums for 12 months (or, if earlier, until the date on which Dr. Simon becomes eligible for coverage under a subsequent employer's medical plan) in an amount equal to the employer portion of such premiums for active employees, subject to her eligibility for, and timely election of, COBRA coverage.

***Severance Subject to Release of Claims.*** Our obligation to provide an executive with severance payments and other benefits under the executive's employment or letter agreement is conditioned on the executive signing a release of claims in favor of us. In addition, our obligation to provide Mr. Evans with severance payments and other benefits under his amended and restated letter agreement is conditioned on his remaining available to provide consulting services to us as reasonably requested by our Board.

***Reduction of Severance in Certain Circumstances.*** If the payments and benefits payable to an executive upon a termination or change in control (i) constitute a "parachute payment" within the meaning of Section 280G of the Internal Revenue Code or (ii) would be subject to the excise tax imposed by Section 4999 of the Internal Revenue Code, then such payments or benefits will be reduced to the extent necessary so that no portion of the payments or benefits retained by the executive will be subject to excise tax under Section 4999 of the Internal Revenue Code, provided that such a reduction would result in the executive's receipt, on an after-tax basis, of the greatest amount of payments and benefits.

**Estimated Payment and Benefits Upon Termination or Change in Control**

The amount of compensation and benefits payable to each NEO who was employed on December 31, 2025 under their current employment agreements in various termination and change in control situations has been estimated in the table below. The value of the equity award vesting acceleration was calculated based on the assumption that the change in control and the NEO's employment termination occurred on December 31, 2025. The per share closing price of our stock on the Nasdaq Global Select Market as of December 31, 2025 was $27.72, which was used as the value of a share of our stock for the calculations below. The value of the option vesting acceleration was calculated by multiplying the number of unvested shares underlying stock options subject to vesting acceleration as of December 31, 2025 by the difference between the per share closing price of our common stock as reported on the Nasdaq Global Select Market on December 31, 2025 and the exercise price for such unvested stock options. The value of the RSU vesting acceleration was calculated by multiplying the number of unvested RSUs subject to vesting acceleration as of December 31, 2025 by the per share closing price of our common stock as reported on the Nasdaq Global Select Market on December 31, 2025.

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| | | | | | |
|:---|:---|:---|:---|:---|:---|
| **Name/Triggering Event** | **Cash Severance<br>($)** | **Bonus Payment<br>($)** | **Health Care Continuation<br>($)** | **Value of Equity Acceleration<br>($)**<sup>(1)</sup> | **Total<br>($)** |
| ***John Evans*** |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Qualifying Termination<sup>(2)</sup> | 755000<br><sup>(3)</sup> | 490750<br><sup>(4)</sup> | 35339<br><sup>(5)</sup> | 2052147<br><sup>(6)</sup> | 3333237 |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in Control |  |  |  | 3459117<br><sup>(7)</sup> | 3459117 |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in Control with a Qualifying Termination<sup>(2)</sup> | 1132500<br><sup>(8)</sup> | 736125<br><sup>(9)</sup> | 53009<br><sup>(10)</sup> | 5412064<br><sup>(11)</sup> | 7333698 |
| ***Giuseppe Ciaramella, Ph.D.*** |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Qualifying Termination<sup>(2)</sup> | 668000<br><sup>(3)</sup> | 367400<br><sup>(4)</sup> | 35339<br><sup>(5)</sup> | 817250<br><sup>(6)</sup> | 1887989 |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in Control |  |  |  | 762360<br><sup>(12)</sup> | 762360 |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in Control with a Qualifying Termination<sup>(2)</sup> | 668000<br><sup>(3)</sup> | 367400<br><sup>(4)</sup> | 35339<br><sup>(5)</sup> | 2297170<br><sup>(11)</sup> | 3367909 |
| ***Sravan K. Emany*** |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Not for Cause Termination | 575000<br><sup>(3)</sup> |  | 35133<br><sup>(5)</sup> |  | 575000 |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in Control with a Qualifying Termination<sup>(2)</sup> | 575000<br><sup>(3)</sup> | 287500<br><sup>(4)</sup> | 35133<br><sup>(5)</sup> | 2013600<br><sup>(11)</sup> | 2876100 |
| ***Christine Bellon, Ph.D.*** |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Not for Cause Termination | 510500<br><sup>(3)</sup> |  | —<br><sup>(5)</sup> |  | 510500 |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in Control with a Qualifying Termination<sup>(2)</sup> | 510500<br><sup>(3)</sup> | 229725<br><sup>(4)</sup> | —<br><sup>(5)</sup> | 1623231<br><sup>(11)</sup> | 2363456 |
| ***Amy Simon, M.D.*** |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Not for Cause Termination | 550000<br><sup>(3)</sup> |  | 35265<br><sup>(5)</sup> |  | 585265 |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in Control with a Qualifying Termination<sup>(2)</sup> | 550000<br><sup>(3)</sup> | 247500<br><sup>(4)</sup> | 35265<br><sup>(5)</sup> | 2267743<br><sup>(11)</sup> | 3100507 |

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<sup>(1)</sup> Based on the per share closing price of a share of our common stock on the Nasdaq Global Select Market on December 31, 2025 ($27.72).

<sup>(2)</sup> A "Qualifying Termination" is a termination not for Cause or for Good Reason, each as defined in the NEO's employment agreement.

<sup>(3)</sup> Represents a cash amount equal to 12 months of the NEO's base salary in effect as of December 31, 2025.

<sup>(4)</sup> Represents a cash amount equal to the NEO's target annual bonus award for the fiscal year ended December 31, 2025.

<sup>(5)</sup> Represents a cash amount equal to 12 months of continued medical and dental benefits for the NEO.

<sup>(6)</sup> Represents the value of 12 months of continued vesting of equity awards as if all such vesting occurred on December 31, 2025.

<sup>(7)</sup> Represents the acceleration of vesting as to 100% of the unvested equity awards held by the NEO, other than the portion of such equity awards that would otherwise have vested during the six-month period following December 31, 2025.

<sup>(8)</sup> Represents a cash amount equal to 18 months of the NEO's base salary in effect as of December 31, 2025.

<sup>(9)</sup> Represents a cash amount equal to one and a half times the NEO's target annual bonus award for the fiscal year ended December 31, 2025.

<sup>(10)</sup> Represents a cash amount equal to 18 months of continued medical and dental benefits for the NEO.

<sup>(11)</sup> Represents the acceleration of vesting as to 100% of the unvested equity awards held by the NEO.

<sup>(12)</sup> Represents the acceleration of vesting as to 50% of the unvested equity awards held by the NEO, other than the portion of such equity awards that would otherwise have vested during the six-month period following December 31, 2025.

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**PAY VERSUS PERFORMANCE**

As required by Section 953(a) of the Dodd-Frank Wall Street Reform and Consumer Protection Act and Item 402(v) of Regulation S-K, we are providing the following information about the relationship between executive compensation actually paid and certain financial performance of our Company.

**Pay Versus Performance Table**

The table below presents information on the compensation of our principal executive officer ("PEO") and our other NEOs in comparison to certain performance metrics for the years ended December 31, 2025, 2024, 2023, 2022 and 2021. The metrics discussed within this section are not those that our compensation committee uses when setting executive compensation. The use of the term "Compensation Actually Paid" ("CAP") is required by SEC rules. Neither CAP nor the total amount reported in the Summary Compensation Table ("SCT") reflect the amount of compensation actually earned or received by or paid to the executives during the applicable year.

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| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
|  |  |  |  |  | **Value of Initial Fixed $100 Investment Based on:** | **Value of Initial Fixed $100 Investment Based on:** |  |
| **Year** | **SCT Total for PEO**<sup>(1)(2)</sup>**<br>($)** | **CAP to PEO**<sup>(1)(3)</sup>**<br>($)** | **Average SCT Total for Other NEOs**<sup>(1)(2)</sup>**<br>($)** | **Average CAP to Other NEOs**<sup>(1)(3)</sup>**<br>($)** | **TSR**<sup>(4)</sup>**<br>($)** | **Peer Group TSR**<sup>(5)</sup>**<br>($)** | **Net Loss**<sup>(6)</sup>**<br>(in thousands)<br>($)** |
| 2025 | 5818525 | 8395673 | 2306507 | 2584445 | 33.95 | 124.75 | (79992) |
| 2024 | 6409631 | 7265610 | 3232451 | 2221711 | 132.27 | 125.21 | (376742) |
| 2023 | 6280099 | 2830315 | 2542318 | 615870 | 145.17 | 125.93 | (132527) |
| 2022 | 9496745 | (13939497) | 3058553 | (9460679) | 208.59 | 120.40 | (289088) |
| 2021 | 13911975 | 17020857 | 4737263 | 6713763 | 425.01 | 133.95 | (370679) |

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<sup>(1)</sup> For each year shown, the PEO was Mr. Evans. For 2021 and 2022, the other NEOs were Dr. Ciaramella and Terry-Ann Burrell, our former CFO. For 2023, they were Dr. Ciaramella, Ms. Burell, Dr. Bellon and Dr. Simon. For 2024, they were Dr. Ciaramella, Mr. Emany (beginning in December 2024), Dr. Bellon, Dr. Simon, and Ms. Burell (ending in August 2024). For 2025, they were Dr. Ciaramella, Mr. Emany, Dr. Bellon and Dr. Simon.

<sup>(2)</sup> The amounts shown in this column are the amounts of total compensation reported for Mr. Evans, or the average total compensation reported for the other NEOs, as applicable, for each corresponding year in the "Total" column of the SCT. Please refer to "*Executive Compensation—Summary Compensation Table*."

<sup>(3)</sup> The amounts shown have been calculated in accordance with Item 402(v) of Regulation S-K and do not reflect compensation actually realized or received by Mr. Evans and other NEOs. In accordance with the requirements of Item 402(v) of Regulation S-K, the following adjustments were made to Mr. Evans' total compensation, or the average total compensation of the other NEOs, as applicable, as reported in the "Total" column in the SCT for 2025:

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| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| **Year** | **SCT Total for PEO <br>($)** | ***Minus* Stock and Option Awards from SCT <br>($)** | ***Plus* Year-End Equity Value of Unvested Awards Granted During Year <br>($)** | ***Plus* Change in Value of Unvested Awards Granted in Prior Years <br>($)** | ***Plus* Value of Awards Granted and Vested During Year ($)** | ***Plus* Change in Value of Prior Years' Awards Vested During Year ($)** | **CAP to PEO <br>($)** |
| 2025 | 5818525 | (4390329) | 4374253 | 2846519 | 314653 | (567948) | 8395673 |

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| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| **Year** | **Avg. SCT Total for Other NEOs <br>($)** | ***Minus* Avg. Stock and Option Awards from SCT <br>($)** | ***Plus* Avg. Year-End Equity Value of Unvested Awards Granted During Year <br>($)** | ***Plus* Avg. Change in Value of Unvested Awards Granted in Prior Years <br>($)** | ***Plus* Avg. Value of Awards Granted and Vested During Year <br>($)** | ***Plus* Avg. Change in Value of Prior Years' Awards Vested During Year <br>($)** | **Average CAP to Other NEOs <br>($)** |
| 2025 | 2306507 | (1255019) | 1266777 | 282514 | 127244 | (143577) | 2584445 |

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<sup>(4)</sup> Cumulative total shareholder return ("TSR") illustrates the value, as of the last day of the indicated fiscal year, of an investment of $100 in the Company's common stock on February 5, 2020 (the first day of trading of our common stock on the Nasdaq Global Select Market) for periods prior to 2025, and on December 31, 2020 for 2025.

<sup>(5)</sup> Peer group TSR illustrates the value, as of the last day of the indicated fiscal year, of an investment of $100 in the peer group's common stock on January 31, 2020 for periods prior to 2025, and on December 31, 2020 for 2025. Peer group TSR includes reinvestment of dividends, weighted according to the peer group's respective stock market capitalizations. The peer group used for this purpose is the Nasdaq Biotechnology Index.

<sup>(6)</sup> The dollar amounts reported represent the amount of net loss reflected in our audited financial statements for the applicable year.

**Analysis of Information Presented in the Pay Versus Performance Table**

As described in more detail above in "C*ompensation Discussion and Analysis*," our executive compensation program reflects a performance-driven compensation philosophy. While we utilize several performance measures to align executive compensation with Company performance, those Company measures are not financial performance measures and are therefore not presented in the Pay Versus Performance Table. Moreover, we generally seek to incentivize long-term performance, and therefore do not specifically align our performance measures with "compensation actually paid" (as computed in accordance with Item 402(v) of Regulation S-K) for a particular year. In accordance with Item 402(v) of Regulation S-K, we are providing the following descriptions of the relationships between information presented in the Pay Versus Performance Table above.

***CAP, TSR of the Company and Peer Group TSR***

The following graph illustrates the relationship of the CAP for our PEO and other NEOs, as calculated pursuant to SEC rules, to our TSR and the TSR of the Nasdaq Biotechnology Index from December 31, 2020, through the end of the period presented in the Pay Versus Performance Table.

![img205556861_3.jpg](img205556861_3.jpg)

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***CAP and Net Loss***

The following graph illustrates the relationship of the CAP for our PEO and other NEOs, as calculated pursuant to SEC rules, to our net loss over the five years presented in the Pay Versus Performance Table.

![img205556861_4.gif](img205556861_4.gif)

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**DIRECTOR COMPENSATION**

This section provides an overview of the compensation awarded to, earned by or paid to members of our Board.

**Director Compensation**

The following table sets forth information concerning the compensation of each of our non-employee directors during the fiscal year ended December 31, 2025. Mr. Evans, our CEO, receives no compensation for his service as a director, and consequently, is not included in this table. Information regarding the compensation of Mr. Evans is included with that of our other NEOs in "Executive Compensation" above.

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| | | | |
|:---|:---|:---|:---|
| **Name** | **Fees Earned<br>or Paid<br>in Cash**<sup>(1)</sup>**<br>($)** | **Option<br>Awards**<sup>(2)</sup>**<br>($)** | **Total<br>($)** |
| Graham Cooper | 67917 | 400234 | 468151 |
| Mark Fishman, M.D. | 95000 | 400234 | 495234 |
| Chirfi Guindo | 55417 | 400234 | 455651 |
| Carole Ho, M.D.<sup>(3)</sup> | 70417 | 400234 | 470651 |
| John Maraganore, Ph.D. | 65417 | 400234 | 465651 |
| Christi Shaw | 62917 | 400234 | 463151 |
| Kathleen Walsh | 65417 | 400234 | 465651 |

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<sup>(1)</sup> Amount represents cash fees earned in fiscal year 2025.

<sup>(2)</sup> The amounts reported in this column represent the aggregate grant date fair value of options to purchase our common stock granted directors in fiscal year 2025 computed in accordance with FASB ASC 718, excluding the effect of estimated forfeitures. The assumptions used to value the options for this purpose are set forth in Note 12, *Stock option and grant plan*, to our audited financial statements filed with our Annual Report on Form 10-K for the fiscal year ended December 31, 2025. As of December 31, 2025, Mr. Cooper held options to purchase 73,475 shares of our common stock, Dr. Fishman held options to purchase 317,155 shares of our common stock, Mr. Guindo held options to purchase 39,086 shares of our common stock, Dr. Ho held options to purchase 121,584 shares of our common stock, Dr. Maraganore held options to purchase 63,170 shares of our common stock, Ms. Shaw held options to purchase 62,160 shares of our common stock and Ms. Walsh held options to purchase 64,772 shares of our common stock.

<sup>(3)</sup> Dr. Ho resigned from our Board effective February 27, 2026.

**Non-Employee Director Compensation Policy**

Under our non-employee director compensation policy in effect for fiscal 2025, each non-employee director is eligible to receive compensation for his or her service on our Board. Each such non-employee director is eligible to receive an annual cash retainer, pro-rated to reflect any partial year of service, as set forth in the table below. In addition, each new non-employee director will be granted an option under the Beam Therapeutics Inc. 2019 Equity Incentive Plan (the "2019 Plan") to purchase shares of common stock having a grant date fair value, determined in accordance with FASB ASC 718, of approximately $770,000 upon his or her initial appointment or election to our Board. The stock options granted to non-employee directors upon initial appointment or election to our Board vest as to one-third of the underlying shares on the first anniversary of the date of grant and in equal monthly installments as to the remainder of the shares for two years thereafter, subject to such director's continued service on our Board through each vesting date. Each non-employee director who was not first elected or appointed to our Board during the calendar year of an annual meeting of our stockholders will annually be granted an option under the 2019 Plan to purchase shares of common stock having a grant date fair value, determined in accordance with FASB ASC 718, of approximately $385,000 on the date of the annual meeting of stockholders. The annual stock options granted to our non-employee directors vest in full on the earlier of the first anniversary of the date of grant and the date of the next year's annual meeting of stockholders, subject to the director's continued service on our Board through the vesting date. Compensation paid to our non-employee directors for their service on our Board is subject to the 2019 Plan, which provides that the aggregate value of all compensation granted to or paid to a director with respect to any calendar year, including equity awards under the 2019 Plan and cash fees paid by us outside of the 2019 Plan, may not exceed $750,000 (or $1,000,000 with respect to a director's first year of service on our Board). The value of equity awards granted to a director is based on the grant date fair value of the awards, assuming a maximum payout. A schedule of our Board and committee cash retainer fees applicable in 2025 and 2026 is set forth in the table below.

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| | | |
|:---|:---|:---|
| **Board and Committee Role** | **2025 Fees<br>($)** | **2026 Fees<br>($)** |
| Board Member | 50000 | 50000 |
| Board Chair | 75000 | 75000 |
| Lead Independent Director | 75000 | 75000 |
| Audit Committee Member | 10000 | 10000 |
| Audit Committee Chair | 20000 | 20000 |
| Compensation Committee Member | 7500 | 7500 |
| Compensation Committee Chair | 15000 | 15000 |
| Nominating and Corporate Governance Committee Member | 5000 | 5000 |
| Nominating and Corporate Governance Committee Chair | 10000 | 10000 |
| Science and Technology Committee Member | 7500 | 7500 |
| Science and Technology Committee Chair | 15000 | 15000 |

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All cash fees are paid quarterly, in arrears, or upon the earlier resignation or removal of the non-employee director. The amount of each payment will be pro-rated for any portion of a calendar quarter that a non-employee director is not serving on our Board, based on the number of calendar days served by such non-employee director.

Each non-employee director is entitled to reimbursement for reasonable travel and other expenses incurred in connection with attending meetings of our Board and any committee on which he or she serves as well as for reasonable expenses incurred related to continuing director education.

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**AUDIT COMMITTEE REPORT**

*The information contained in this report shall not be deemed to be "soliciting material" or "filed" or incorporated by reference in future filings with the SEC, or subject to the liabilities of Section 18 of the Exchange Act, except to the extent that the Company specifically incorporates it by reference into a document filed under the Securities Act of 1933, as amended, (the "Securities Act") or the Exchange Act.* 

We operate in accordance with a written charter adopted by our Board and reviewed annually by the audit committee. We are responsible for overseeing the quality and integrity of Beam Therapeutics Inc.'s accounting, auditing and financial reporting practices. In accordance with the rules of the SEC and Nasdaq, the audit committee is composed entirely of members who are independent, as defined by the listing standards of Nasdaq and Beam Therapeutics Inc.'s Corporate Governance Guidelines. Further, our Board has determined that each member is an audit committee financial expert as defined by the rules of the SEC.

The audit committee met four times during fiscal 2025 with Beam Therapeutics Inc.'s management and Deloitte & Touche LLP ("Deloitte"), Beam Therapeutics Inc.'s independent registered public accounting firm, including, but not limited to, meetings held to review and discuss the annual audited and quarterly financial statements and the Company's earnings press releases.

We believe that we fully discharged our oversight responsibilities as described in our charter, including with respect to the audit process. We reviewed and discussed our audited financial statements for the fiscal year ended December 31, 2025, including internal control testing under Section 404 of the Sarbanes-Oxley Act, with management and Deloitte. Management has the responsibility for the preparation of Beam Therapeutics Inc.'s financial statements, and Deloitte has the responsibility for the audit of those statements. The Audit Committee discussed with Deloitte the matters required to be discussed by rules and regulations of the Public Company Accounting Oversight Board (the "PCAOB") and the SEC. We received the written disclosures and the letter from Deloitte required by applicable requirements of the PCAOB standards concerning any relationships between Deloitte and Beam Therapeutics Inc. and the potential effects of any disclosed relationships on Deloitte's independence, and discussed with Deloitte its independence. We reviewed with Deloitte their audit plan, audit scope, identification of audit risks and their audit efforts, and discussed and reviewed the results of Deloitte's examination of Beam Therapeutics Inc.'s financial statements both with and without management.

The Audit Committee considered any fees paid to Deloitte for the provision of non-audit related services and does not believe that these fees compromise Deloitte's independence in performing the audit.

Based on these reviews and discussions with management and Deloitte, we approved the inclusion of Beam Therapeutics Inc.'s audited financial statements in its Annual Report on Form 10-K for the fiscal year ended December 31, 2025 for filing with the SEC. We also have selected Deloitte as the independent registered public accounting firm for the fiscal year ending December 31, 2026, subject to ratification by Beam Therapeutics Inc.'s shareholders.

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| |
|:---|
| Audit Committee |
| Graham Cooper (Chair) |
| Christi Shaw |
| Kathleen Walsh |

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**DELINQUENT SECTION 16(a) REPORTS**

Our executive officers and directors and persons who own beneficially more than 10% of our equity securities are required under Section 16(a) of the Securities Exchange Act of 1934 to file reports of ownership and changes in their ownership of our securities with the SEC. They must also furnish copies of these reports to us. Based solely on a review of the copies of reports furnished to us and written representations that no other reports were required, we believe that for our 2025 fiscal year our executive officers, directors and 10% beneficial owners complied with all applicable Section 16(a) filing requirements.

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**CERTAIN RELATIONSHIPS AND RELATED PERSON TRANSACTIONS**

The following is a description of transactions since January 1, 2025 to which we have been a participant in which the amount involved, exceeded or will exceed $120,000, and in which any of our directors, executive officers or holders of more than 5% of our capital stock, or any members of their immediate family, had or will have a direct or indirect material interest.

**Director Affiliations**

During the fiscal year ended December 31, 2025, one of our directors was affiliated with entities that beneficially owned 5% or more of our common stock, as indicated below:

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| | |
|:---|:---|
| **Director** | **Principal Stockholder** |
| John Maraganore | Funds affiliated with ARCH Venture Partners |

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**Investor Rights Agreement**

During fiscal year 2025, we were party to an amended and restated investor rights agreement (the "Investor Rights Agreement") with Dr. Mark Fishman, who is a member of our Board, and with certain funds affiliated with ARCH Venture Partners. The Investor Rights Agreement imposed certain affirmative obligations on us, and also granted certain rights to the counterparties, including certain registration rights with respect to the registrable securities held by them. These provisions of the Investor Rights Agreement terminated automatically pursuant to the terms of the Investor Rights Agreement in February 2025 upon the fifth anniversary of the completion of our initial public offering.

**Orbital License and Research Collaboration Agreement** 

On September 2, 2022, we entered into a license and research collaboration agreement (the "Orbital Agreement") with Orbital Therapeutics, Inc. ("Orbital"), pursuant to which we and Orbital granted the other licenses to certain technology controlled by us necessary or reasonably useful for the non-viral delivery or the design or manufacture of ribonucleic acid for the prevention, treatment or diagnosis of human disease. Concurrently with our entry into the Orbital Agreement, Orbital issued us 75 million shares of its common stock. During 2025, Giuseppe Ciaramella, our President, was party to a consulting agreement with Orbital pursuant to which he served as a scientific advisor in addition to his current responsibilities to Beam. Pursuant to his consulting agreement, Dr. Ciaramella was granted common stock of Orbital that vested subject to certain service-based requirements. Immediately after our entry into the Orbital Agreement, the board of directors of Orbital included two members of our current Board (John Evans and John Maraganore, Ph.D.), and one former member of our Board (Kristina Burow). Dr. Maraganore held common stock of Orbital that vested subject to certain service-based requirements. In addition, each of ARCH Venture Partners, which was an affiliate of the Company in 2025, and Dr. Maraganore, was a holder of common stock and Series Seed Preferred Stock of Orbital. Collectively, Dr. Ciaramella and Dr. Maraganore held less than 10% of the outstanding shares of Orbital, and ARCH Venture Partners held approximately 30% of the outstanding shares of Orbital. Orbital was acquired by Bristol-Myers Squibb Company in December 2025.

**Director and Officer Indemnification and Insurance**

We have agreed to indemnify each of our directors and executive officers against certain liabilities, costs and expenses, and have purchased directors' and officers' liability insurance. We also maintain a general liability insurance policy which covers certain liabilities of directors and officers arising out of claims based on acts or omissions in their capacities as directors or officers.

**Participation in Public Offering** 

In March 2025, we sold an aggregate of 16,151,686 shares of our common stock at an offering price of $28.48 per share and pre-funded warrants to purchase 1,404,988 shares of our common stock at an offering price of $28.47 per warrant, pursuant to an underwritten registered direct offering (the "Offering"), which included sales to certain of our 5% stockholders and their affiliates. Entities affiliated with FMR LLC purchased 3,160,112 shares for an aggregate purchase price of approximately $90.0 million, entities affiliated with Farallon Capital Partners purchased 1,404,988 shares and 1,404,988 pre-funded warrants for an aggregate purchase price of approximately $80.0 million, entities affiliated with Ark Investment Management LLC purchased 526,685 shares for an aggregate purchase price of approximately $15.0 million, and entities affiliated with The Vanguard Group purchased 526,685 shares for an aggregate purchase price of approximately $15.0 million. Such purchases were made through the underwriters at the offering price. See "Security Ownership of Certain Beneficial Owners and Management" for additional information about shares held by these entities.

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**Related Person Transaction Policy**

Our Board has adopted a written related person transaction policy setting forth the policies and procedures for the review and approval or ratification of related person transactions. This policy covers any transaction, arrangement or relationship, or any series of similar transactions, arrangements or relationships, in which we were or are to be a participant, where the amount involved exceeds $120,000 and one of our executive officers, directors, director nominees or 5% stockholders, or their immediate family members, each of whom we refer to as a "related person," had, has or will have a direct or indirect material interest, including without limitation, purchases of goods or services by or from the related person or entities in which the related person has a material interest, indebtedness, guarantees of indebtedness and employment by us of a related person. In reviewing and approving any such transactions, our audit committee is tasked to consider all relevant facts and circumstances, including, but not limited to, whether the transaction is on terms comparable to those that could be obtained in an arm's length transaction and the extent of the related person's interest in the transaction. A related person transaction reviewed under the policy will be considered approved or ratified if it is authorized by our audit committee after full disclosure of the related person's interest in the transaction. As appropriate for the circumstances, our audit committee will review and consider:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•the related person's interest in the related person transaction;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•the approximate dollar value of the amount involved in the related person transaction;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•the approximate dollar value of the amount of the related person's interest in the transaction without regard to the amount of any profit or loss;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•whether the transaction was undertaken in the ordinary course of our business;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•whether the terms of the transaction are no less favorable to us than the terms that could have been reached with an unrelated third party;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•the purpose of, and the potential benefits to us of, the transaction; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•any other information regarding the related person transaction or the related person in the context of the proposed transaction that would be material to investors in light of the circumstances of the particular transaction.

Our audit committee may approve or ratify the transaction only if our audit committee determines that, under all of the circumstances, the transaction is in our best interests. Our audit committee may impose any conditions on the related person transaction that it deems appropriate. Each of the transactions described in this section occurred prior to the adoption of this policy or was approved in accordance with this policy.

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**PROPOSAL NO. 1—ELECTION OF DIRECTORS**

In accordance with our certificate of incorporation and bylaws, our Board is divided into three classes of approximately equal size. The members of each class are elected to serve a three-year term with the term of office of each class ending in successive years. John Evans, John Maraganore, Ph.D., and Christi Shaw are the Class III directors whose terms expire at the Annual Meeting. Each of Mr. Evans, Dr. Maraganore and Ms. Shaw have been nominated for and have agreed to stand for re-election to our Board to serve as Class III directors of our Company for three-year terms and until his or her successor is duly elected and qualified or until his or her earlier death, resignation or removal.

**OUR BOARD RECOMMENDS THAT STOCKHOLDERS VOTE "FOR" THE ELECTION OF EACH OF THE NOMINEES FOR CLASS III DIRECTOR, AND PROXIES SOLICITED BY OUR BOARD WILL BE VOTED IN FAVOR THEREOF, UNLESS A STOCKHOLDER HAS INDICATED OTHERWISE ON THE PROXY.**

**(PROPOSAL 1 ON YOUR PROXY CARD)**

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**PROPOSAL NO. 2—RATIFICATION OF SELECTION OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM**

We are asking our stockholders to ratify our audit committee's appointment of Deloitte & Touche LLP ("Deloitte") as our independent registered public accounting firm for the fiscal year ending December 31, 2026. Deloitte has served as our independent registered public accounting firm since 2018.

Our audit committee annually reviews our independent registered public accounting firm's independence, including reviewing all relationships between our independent registered public accounting firm and us and any disclosed relationships or services that may impact the objectivity and independence of our independent registered public accounting firm, and our independent registered public accounting firm's performance. Although ratification is not required by our bylaws or otherwise, our Board is submitting the appointment of Deloitte to our stockholders for ratification as a matter of good corporate practice. If the appointment is not ratified, our audit committee will consider whether it is appropriate to select another independent registered public accounting firm. Even if the appointment is ratified, our audit committee in its discretion may appoint a different registered public accounting firm at any time during the year if the committee determines that such a change would be in the best interests of our Company and our stockholders.

Before selecting Deloitte, our audit committee carefully considered that firm's qualifications as an independent registered public accounting firm for our Company. This included a review of its performance in prior years, including the firm's efficiency, integrity and competence in the fields of accounting and auditing. Our audit committee has expressed its satisfaction with Deloitte in all of these respects.

Deloitte served as independent registered public accounting firm for our Company with respect to the audit of the Company's consolidated financial statements for the fiscal year ended December 31, 2025 and has been engaged by our audit committee to serve as our independent registered public accounting firm with respect to the audit of our consolidated financial statements for the fiscal year ending December 31, 2026. Representatives of Deloitte will be present at the Annual Meeting, will have the opportunity to make a statement if they desire to do so and will be available to respond to appropriate questions from stockholders.

**Principal Accountant Fees and Services** 

The following table sets forth the aggregate fees billed for the audits of fiscal years ended December 31, 2025 and 2024, and audit-related fees and all other fees billed in each of the last two fiscal years.

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| | | |
|:---|:---|:---|
| **Fee Category** | **2025** | **2024** |
| Audit Fees<sup>(1)</sup> | $1378504 | $1259355 |
| Audit-Related Fees |  |  |
| Tax Fees<sup>(2)</sup> | 248400 | 67980 |
| All Other Fees<sup>(3)</sup> | 269993 | 1895 |
| Total Fees | $1896897 | $1329230 |

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<sup>(1)</sup> Consist of aggregate fees for professional services provided in connection with the annual audit of our consolidated financial statements, the review of our quarterly condensed consolidated financial statements, consultations on accounting matters directly related to the audit, and comfort letters, consents and assistance with and review of documents filed with the SEC.

<sup>(2)</sup> Consists of aggregate fees for tax compliance, tax advice and tax planning services, including the review and preparation of our federal and state income tax returns.

<sup>(3)</sup> Represents aggregate fees billed for services provided by our independent registered public accounting firm other than those disclosed above and consists of consulting services and fees for accessing Deloitte's online accounting research tool.

**Audit Committee Pre-Approval Policy and Procedures**

Our audit committee has adopted policies and procedures relating to the approval of all audit and non-audit services that are to be performed by our independent registered public accounting firm. This policy provides that we will not engage our independent registered public accounting firm to render audit or non-audit services, other than non-audit services that are "de minimis" under Section 10A(i)(1)(B) of the Exchange Act, unless the service or category of service is specifically approved in advance by our audit committee or the engagement is entered into pursuant to the pre-approval procedure described below.

From time to time, our audit committee, or one or more members of the audit committee delegated by the audit committee, may pre-approve all auditing services and the terms thereof and non-audit services (other than non-audit services prohibited under Section

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10A(g) of the Exchange Act or the applicable rules of the SEC or the Public Company Accounting Oversight Board) to be provided to the Company by the independent auditors during the next 12 months, provided that if the audit committee delegates one or more of its members to make such pre-approval decisions then such delegate(s) shall present all pre-approval decisions to the full audit committee at its next regularly scheduled meeting. Any such pre-approval details the particular service or category of service to be provided and is also generally subject to a maximum dollar amount. The audit committee also regularly receives updates from management about the services actually performed and the associated fees and expenses actually incurred. Management must obtain the specific prior approval of the audit committee for each engagement of the independent registered public accounting firm to perform other audit-related or other non-audit services, except that one or more members of the audit committee delegated by the audit committee may pre-approve engagements for non-audit services and any such approved non-audit services must then be presented to the audit committee at its next meeting. The audit committee does not delegate its responsibility to approve services performed by the independent registered public accounting firm to any member of management.

During the fiscal years ended December 31, 2025 and 2024, all of the services provided to us by Deloitte were in accordance with the pre-approval policies and procedures described above.

**OUR BOARD RECOMMENDS THAT STOCKHOLDERS VOTE "FOR" THE PROPOSAL TO RATIFY DELOITTE & TOUCHE LLP AS OUR INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR 2026, AND PROXIES SOLICITED BY OUR BOARD WILL BE VOTED IN FAVOR THEREOF, UNLESS A STOCKHOLDER HAS INDICATED OTHERWISE ON THE PROXY.**

**(PROPOSAL 2 ON YOUR PROXY CARD).**

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**PROPOSAL NO. 3—ADVISORY VOTE ON NAMED EXECUTIVE OFFICER COMPENSATION**

We are providing our stockholders with an opportunity to cast a non-binding, advisory vote to approve the compensation of our NEOs, as disclosed in this proxy statement. This proposal, which is commonly referred to as "say-on-pay," is required by the Dodd-Frank Wall Street Reform and Consumer Protection Act (the "Dodd-Frank Act"), which added Section 14A to the Exchange Act. This vote is not intended to address any specific item of compensation, but rather the overall compensation of our NEOs and the philosophy, policies and practices described in this proxy statement. The compensation of our NEOs subject to the vote is disclosed in the section titled "Compensation Discussion and Analysis," as well as in the compensation tables and the related narrative disclosure contained in the sections titled "Executive Compensation" and "Pay Versus Performance." As discussed in those disclosures, our executive compensation program is designed to reward value creation for stockholders and to attract, motivate and retain our executive officers, who are critical to our success. Under this program, our NEOs are rewarded for the achievement of our short- and long-term strategic and financial goals, which we believe serves to enhance short- and long-term value creation for our stockholders. Our compensation program contains elements of cash and equity-based compensation and is designed to align the interests of our executives with those of our stockholders and paying for performance.

Accordingly, our Board is asking our stockholders to indicate their support for the compensation of our NEOs as described in this proxy statement by casting a non-binding advisory vote "FOR" the following resolution:

"RESOLVED, that the compensation paid to the Company's named executive officers, as disclosed pursuant to Item 402 of Regulation S-K, including the Compensation Discussion and Analysis, compensation tables and the related narrative disclosure, is hereby APPROVED."

As this vote is advisory, it will not be binding upon our Board or compensation committee, and neither our Board nor our compensation committee will be required to take any action as a result of the outcome of this vote. However, our compensation committee will carefully consider the outcome of this vote when considering future executive compensation policies and decisions.

**OUR BOARD RECOMMENDS THAT STOCKHOLDERS VOTE "FOR" PROPOSAL NO. 3 TO APPROVE, ON AN ADVISORY BASIS, THE COMPENSATION OF OUR NEOS, AS DISCLOSED IN THIS PROXY STATEMENT.**

**(PROPOSAL 3 ON YOUR PROXY CARD).**

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**TRANSACTION OF OTHER BUSINESS**

Our Board does not know of any other matters to be raised at the Annual Meeting. If any other matters not mentioned in this proxy statement are properly brought before the meeting, the appropriate executive officers and directors named in this proxy statement intend to use their discretionary voting authority under the proxy to vote the proxy in accordance with their best judgment on those matters.

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**SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT**

The following table sets forth information, as of December 31, 2025, unless otherwise indicated, regarding the beneficial ownership of our common stock for (i) stockholders who beneficially owned more than 5% of our common stock, (ii) each of our directors and NEOs and (iii) all of our directors and executive officers as a group.

The number of shares beneficially owned by each stockholder is determined under rules issued by the SEC. Under these rules, a person is deemed to be a "beneficial" owner of a security if that person has or shares voting power or investment power, which includes the power to dispose of or to direct the disposition of such security. Except as indicated in the footnotes below, we believe, based on the information furnished to us, that the individuals and entities named in the table below have sole voting and investment power with respect to all shares of common stock beneficially owned by them, subject to any applicable community property laws.

In computing the number of shares beneficially owned by an individual or entity, shares of common stock subject to options, warrants, restricted stock units, or other rights held by such person that are currently exercisable or have vested or that will become exercisable or will have vested within 60 days of December 31, 2025 are considered outstanding, although these shares are not considered outstanding for purposes of computing the percentage ownership of any other person. On December 31, 2025, there were 100,557,094 shares of our common stock outstanding. Unless noted otherwise, the address of all listed stockholders is 238 Main Street, Cambridge, MA 02142.

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| | | |
|:---|:---|:---|
| **Name of Beneficial Owner** | **Number of<br>Shares<br>Beneficially<br>Owned** | **Percentage of<br>Shares<br>Beneficially<br>Owned** |
| ***5% or Greater Stockholders:*** |  |  |
| FMR LLC and affiliates<sup>(1)</sup> | 12750369 | 12.7% |
| Ark Investment Management LLC and affiliates<sup>(2)</sup> | 12467189 | 12.4% |
| Farallon Capital Partners LP and affiliates<sup>(3)</sup> | 10141856 | 10.1% |
| The Vanguard Group<sup>(4)</sup> | 7691528 | 7.6% |
| BlackRock, Inc.<sup>(5)</sup> | 7499930 | 7.5% |
| State Street Corporation<sup>(6)</sup> | 5228529 | 5.2% |
| ***Directors and Named Executive Officers:*** |  |  |
| John Evans<sup>(7)</sup> | 2033174 | 2.0% |
| Giuseppe Ciaramella, Ph.D.<sup>(8)</sup> | 825231 | \* |
| Sravan K. Emany<sup>(9)</sup> | 60372 | \* |
| Christine Bellon, Ph.D.<sup>(10)</sup> | 226993 | \* |
| Amy Simon, M.D.<sup>(11)</sup> | 194783 | \* |
| Graham Cooper<sup>(12)</sup> | 73475 | \* |
| Mark Fishman, M.D.<sup>(13)</sup> | 334162 | \* |
| Chirfi Guindo<sup>(14)</sup> | 15080 | \* |
| John Maraganore, Ph.D.<sup>(15)</sup> | 63170 | \* |
| Christi Shaw<sup>(16)</sup> | 51259 | \* |
| Kathleen Walsh<sup>(17)</sup> | 64772 | \* |
| All Executive Officers and Directors as a group (11 persons)<sup>(18)</sup> | 3942471 | 3.8% |

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\* Less than 1% of the outstanding shares of our common stock.

<sup>(1)</sup> FMR LLC has sole voting power over 12,719,555 shares of our common stock and sole dispositive power over 12,750,369 shares of our common stock. Abigail P. Johnson may be deemed to beneficially own certain of the shares of common stock beneficially owned by FMR LLC and has sole dispositive power over 12,750,369 shares of our common stock. The address of each of the foregoing persons is 245 Summer Street, Boston, Massachusetts 02210. The information reported is based solely on a Schedule 13G/A filed jointly by the foregoing persons on February 5, 2026, reporting beneficial ownership as of December 31, 2025.

<sup>(2)</sup> Ark Investment Management LLC has sole voting power over 11,797,335 shares of our common stock, shared voting power over 232,271 shares of our common stock and sole dispositive power over 12,467,189 shares of our common stock. Catherine D. Wood beneficially owns the shares of common stock beneficially owned by Ark Investment Management LLC and has sole voting power over 12,029,706 shares of our common stock and sole dispositive power over 12,467,189 shares of our common stock. The address of each of the foregoing persons is 200 Central Ave., St. Petersburg, FL 33701. The information reported is based solely on a Schedule 13G/A filed jointly by the foregoing persons on February 3, 2026, reporting beneficial ownership as of December 31, 2025.

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<sup>(3)</sup> Farallon Capital Partners LP and its affiliates have shared voting power over 10,141,856 shares of our common stock and shared dispositive power over 10,141,856 shares of our common stock. The address of Farallon Capital Partners LP is One Maritime Plaza, Suite 2100, San Francisco, CA 94111. The information reported is based solely on a Schedule 13G/A filed by Farallon Capital Partners LP on February 5, 2026, reporting beneficial ownership as of December 31, 2025.

<sup>(4)</sup> The Vanguard Group has shared voting power with respect to 123,986 shares of our common stock, sole dispositive power with respect to 6,968,129 shares of our common stock and shared dispositive power with respect to 196,714 shares of our common stock, and may also be deemed to beneficially own an additional 526,685 shares purchased in the Offering. The principal business address of The Vanguard Group is 100 Vanguard Blvd., Malvern, PA 19355. The information reported is based solely on a Schedule 13G filed by The Vanguard Group on February 13, 2024, reporting beneficial ownership as of December 31, 2023 and internal company records related to the Offering. On March 26, 2026, The Vanguard Group filed a Schedule 13G/A to report that following an internal reorganization, The Vanguard Group no longer has beneficial ownership over any shares of our common stock as of March 13, 2026. The Schedule 13G/A states that certain subsidiaries or business divisions of subsidiaries of The Vanguard Group that formerly had, or were deemed to have, beneficial ownership with The Vanguard Group, will report beneficial ownership separately (on a disaggregated basis) from The Vanguard Group.

<sup>(5)</sup> BlackRock, Inc. has sole voting power over 7,338,600 shares of our common stock and sole dispositive power over 7,499,930 shares of our common stock. All such shares are beneficially owned by BlackRock, Inc., a parent holding company, and on behalf of its subsidiaries: (i) BlackRock Advisors, LLC; (ii) BlackRock (Netherlands) B.V.; (iii) BlackRock Institutional Trust Company, National Association; (iv) BlackRock Asset Management Ireland Limited; (v) BlackRock Financial Management, Inc.; (vi) BlackRock Asset Management Schweiz AG; (vii) BlackRock Investment Management, LLC; (viii) BlackRock Investment Management (UK) Limited; (ix) BlackRock Asset Management Canada Limited; (x) BlackRock Investment Management (Australia) Limited; (xi) BlackRock Fund Advisors; and (xii) BlackRock Fund Managers Ltd. The address of BlackRock, Inc. is 55 East 52nd, New York, NY 10055. The information reported is based solely on a Schedule 13G/A filed by BlackRock, Inc. on April 17, 2025, reporting beneficial ownership as of March 31, 2025.

<sup>(6)</sup> State Street Corporation has shared voting power over 4,949,918 shares of our common stock and shared dispositive power over 5,228,529 shares of our common stock. All such shares are beneficially owned by State Street Corporation, a parent holding company, and on behalf of its subsidiaries: (i) SSGA Funds Management, Inc.; (ii) State Street Global Advisors Europe Limited; (iii) State Street Global Advisors Limited; (iv) State Street Global Advisors Trust Company; and (v) State Street Global Advisors, Ltd. The address of State Street Corporation is One Congress St., Suite 1, Boston, MA 02114. The information reported is based solely on a Schedule 13G filed by State Street Corporation on February 9, 2026, reporting beneficial ownership as of December 31, 2025.

<sup>(7)</sup> Includes (i) options to purchase 1,121,322 shares of our common stock that are exercisable within 60 days of December 31, 2025 and (ii) 103,000 shares of our common stock held by the John M. Evans, III 2018 Irrevocable Trust.

<sup>(8)</sup> Includes options to purchase 710,015 shares of our common stock that are exercisable within 60 days of December 31, 2025.

<sup>(9)</sup> Includes options to purchase 46,666 shares of our common stock that are exercisable within 60 days of December 31, 2025.

<sup>(10)</sup> Includes options to purchase 165,826 shares of our common stock that are exercisable within 60 days of December 31, 2025.

<sup>(11)</sup> Includes options to purchase 193,039 shares of our common stock that are exercisable within 60 days of December 31, 2025.

<sup>(12)</sup> Consists of options to purchase shares of our common stock that are exercisable within 60 days of December 31, 2025.

<sup>(13)</sup> Includes options to purchase 317,155 shares of our common stock that are exercisable within 60 days of December 31, 2025.

<sup>(14)</sup> Consists of options to purchase shares of our common stock that are exercisable within 60 days of December 31, 2025.

<sup>(15)</sup> Consists of options to purchase shares of our common stock that are exercisable within 60 days of December 31, 2025.

<sup>(16)</sup> Consists of options to purchase shares of our common stock that are exercisable within 60 days of December 31, 2025.

<sup>(17)</sup> Consists of options to purchase shares of our common stock that are exercisable within 60 days of December 31, 2025.

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<sup>(18)</sup> Includes (i) options to purchase 2,821,779 shares of common stock that are exercisable within 60 days of December 31, 2025 and (ii) 103,000 shares of our common stock held by the John M. Evans, III 2018 Irrevocable Trust.

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**SECURITIES AUTHORIZED FOR ISSUANCE UNDER EQUITY COMPENSATION PLANS**

The following table provides information as of December 31, 2025 with respect to the shares of our common stock that may be issued under our existing equity compensation plans.

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| | | | |
|:---|:---|:---|:---|
| **Plan Category** | **Number of securities to be issued upon exercise of outstanding options, warrants and rights <br>(a)** | **Weighted-average exercise price of outstanding options, warrants and rights**<sup>(1)</sup>**<br>(b)** | **Number of securities remaining available for issuance under equity compensation plans (excluding securities reflected in column (a))<br>(c)** |
| Equity compensation plans approved by security holders |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2017 Stock Option and Grant Plan | 1325028 | $3.37 | —<br><sup>(2)</sup> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2019 Equity Incentive Plan | 9991521 | $39.93 | 1888002<br><sup>(3)</sup> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2019 Employee Stock Purchase Plan | —<br><sup>(4)</sup> |  | 3590328<br><sup>(5)</sup> |
| Equity compensation plans not approved by security holders |  |  |  |
| Total | 11316549 | $35.65 | 5478330 |

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<sup>(1)</sup> The weighted-average exercise price does not reflect the shares of our common stock that will be issued in connection with the settlement of restricted stock unit awards, which have no exercise price.

<sup>(2)</sup> No further grants were made under the 2017 Stock Option and Grant Plan after the completion of our initial public offering on February 5, 2020.

<sup>(3)</sup> The number of shares of our common stock reserved for issuance under the 2019 Plan will automatically increase on January 1 of each year through and including January 1, 2029 by 4% of the total number of shares of our capital stock outstanding on December 31 of the preceding calendar year or a lesser number of shares determined by our Board. Pursuant to the terms of the 2019 Plan, an additional 4,069,958 shares were added to the number of available shares, effective January 1, 2026.

<sup>(4)</sup> Does not include purchase rights accruing under the Amended and Restated 2019 Employee Stock Purchase Plan ("ESPP") because the purchase price (and therefore the number of shares to be purchased) will not be determined until the end of the applicable purchase period.

<sup>(5)</sup> The number of shares of our common stock reserved for issuance under the ESPP will automatically increase on January 1 of each year through and including January 1, 2029 by the lesser of (i) 1% of the total number of shares of our capital stock outstanding on December 31 of the preceding calendar year and (ii) a number of shares determined by our Board, up to a maximum of 5,083,204 shares in the aggregate. Pursuant to the terms of the ESPP, an additional 1,017,489 shares were added to the number of available shares, effective January 1, 2026.

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**GENERAL MATTERS**

**Shareholder Proposals for our 2027 Annual Meeting of Stockholders**

***Requirements for Shareholder Proposals to be Considered for Inclusion in our Proxy Materials.*** To be considered for inclusion in next year's proxy statement, shareholder proposals pursuant to Rule 14a-8 under the Exchange Act must be received by our Secretary, at Beam Therapeutics Inc., 238 Main Street, Cambridge, MA 02142 no later than December 18, 2026, which is one hundred and twenty (120) days prior to April 17, 2027.

***Requirements for Shareholder Proposals or Director Nominations to be Brought Before an Annual Meeting*.** Our bylaws provide that, for shareholder nominations to our Board or other proposals to be considered at an annual meeting, the shareholder must have given timely notice thereof in writing to the Secretary, at Beam Therapeutics Inc., 238 Main Street, Cambridge, MA 02142. To be timely for the 2027 annual meeting, the shareholder's notice must be delivered to or mailed and received by us not before February 3, 2027 or after March 5, 2027, which is not more than one hundred and twenty (120) days, and not less than ninety (90) days, before the anniversary date of the preceding annual meeting, except that if the 2027 annual meeting of stockholders is more than thirty (30) days before or after the anniversary date of the previous year's annual meeting, we must receive the notice not later than sixty (60) days prior to the annual meeting date. Such notice must provide the information required by our bylaws with respect to each matter the shareholder proposes to bring before the 2027 annual meeting.

In addition to satisfying the provisions in our bylaws relating to nominations of director candidates, including the deadline for written notices, to comply with the SEC's universal proxy rule, shareholders who intend to solicit proxies in support of director nominees other than the Company's nominees in compliance with Rule 14a-19 under the Exchange Act must provide notice that sets forth the information required by Rule 14a-19.

**Annual Report**

Upon written request, we will provide without charge to each stockholder who does not otherwise receive a copy of our annual report to shareholders a copy of our Annual Report on Form 10-K filed with the SEC on February 24, 2026 for the fiscal year ended December 31, 2025. Please address all requests to:

Christine Bellon, Secretary

Beam Therapeutics Inc.

238 Main Street

Cambridge, MA 02142

**Householding of Proxy Materials**

SEC rules concerning the delivery of annual disclosure documents allow us or your broker to send a single notice or, if applicable, a single set of our proxy materials to any household at which two or more of our stockholders reside, if we or your broker believe that the stockholders are members of the same family, unless we have received contrary instructions from one or more of the stockholders. This practice, referred to as "householding," benefits both you and us. It reduces the volume of duplicate information received at your household and helps to reduce our expenses. The rule applies to our notices, annual reports, proxy statements and information statements.

We will undertake to deliver promptly, upon written or oral request, a separate copy to a stockholder at a shared address to which a single copy of the notice or proxy materials was delivered. You may make a written request by sending a notification to our Secretary at the address above, or an oral request by calling (857) 327-8775, in each case providing your name, your shared address and the address to which we should direct the additional copy of the notice or proxy materials. Multiple stockholders sharing an address who have received one copy of a mailing and would prefer us to mail each stockholder a separate copy of future mailings should contact us at our principal executive offices. Additionally, if current stockholders with a shared address received multiple copies of a mailing and would prefer us to mail one copy of future mailings to stockholders at the shared address, notification of that request may also be made through our principal executive offices. Stockholders who participate in householding will continue to have access to and utilize separate proxy voting instructions.

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