# EDGAR Filing Document

**Accession Number:** 0001009258
**File Stem:** 0001213900-25-110851
**Filing Date:** 2025-11
**Character Count:** 19667
**Document Hash:** d36846665eaf15f9f6f83ef02aaaca35
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001213900-25-110851.hdr.sgml**: 20251114

**ACCESSION NUMBER**: 0001213900-25-110851

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20250930

**FILED AS OF DATE**: 20251114

**DATE AS OF CHANGE**: 20251114

**EFFECTIVENESS DATE**: 20251114

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** DEERFIELD MANAGEMENT COMPANY, L.P.
- **CENTRAL INDEX KEY:** 0001009258

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-05366
- **FILM NUMBER:** 251486363

**BUSINESS ADDRESS:**
- **STREET 1:** 345 PARK AVENUE SOUTH, 12TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10010
- **BUSINESS PHONE:** 2125511600

**MAIL ADDRESS:**
- **STREET 1:** 345 PARK AVENUE SOUTH, 12TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10010

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)
- **DATE OF NAME CHANGE:** 20180109

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** DEERFIELD MANAGEMENT CO
- **DATE OF NAME CHANGE:** 20131114

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** DEERFIELD MANAGEMENT CO /NY
- **DATE OF NAME CHANGE:** 19981022

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 09-30-2025

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** DEERFIELD MANAGEMENT COMPANY L.P.<br>**Address:** 345 Park Avenue South 12th Floor<br>New York, NY 10010

**Form 13F File Number:** 028-05366

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Deerfield UGP LLC its general partner<br>**Title:** Chief Financial Officer<br>**Phone:** 212-551-1600

**Signature, Place, and Date of Signing:**

/s/ Jonathan Isler  New York, NY  11-14-2025<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 1

**Form 13F Information Table Entry Total:** 152

**Form 13F Information Table Value Total:** $6550740151

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

| No.   | Name              | Form 13F File Number   |
|:---|:---|:---|
|  | Deerfield UGP LLC | 028-25875              |

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| 10X GENOMICS INC | CL A COM | 88025U109 |  | 3053288 | 261188 | SH |  | DFND | 1 | 261188 | 0 | 0 |
| ACADIA HEALTHCARE COMPANY IN | COM | 00404A109 |  | 29439640 | 1189000 | SH |  | DFND | 1 | 1189000 | 0 | 0 |
| ADAPTHEALTH CORP | COMMON STOCK | 00653Q102 |  | 102725684 | 11477730 | SH |  | DFND | 1 | 11477730 | 0 | 0 |
| ADAPTIVE BIOTECHNOLOGIES COR | COM | 00650F109 |  | 902507 | 60328 | SH |  | DFND | 1 | 60328 | 0 | 0 |
| ALECTOR INC | COM | 014442107 |  | 3123368 | 1055192 | SH |  | DFND | 1 | 1055192 | 0 | 0 |
| ALIGN TECHNOLOGY INC | COM | 016255101 |  | 4105839 | 32789 | SH |  | DFND | 1 | 32789 | 0 | 0 |
| ALIGNMENT HEALTHCARE INC | COM | 01625V104 |  | 1796338 | 102942 | SH |  | DFND | 1 | 102942 | 0 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 |  | 30978360 | 67935 | SH |  | DFND | 1 | 67935 | 0 | 0 |
| ALPHATEC HLDGS INC | COM NEW | 02081G201 |  | 948909 | 65262 | SH |  | DFND | 1 | 65262 | 0 | 0 |
| ANNEXON INC | COM | 03589W102 |  | 1780935 | 583913 | SH |  | DFND | 1 | 583913 | 0 | 0 |
| ARROWHEAD PHARMACEUTICALS IN | COM | 04280A100 |  | 34248570 | 993000 | SH |  | DFND | 1 | 993000 | 0 | 0 |
| ARS PHARMACEUTICALS INC | COM | 82835W108 |  | 75413311 | 7503812 | SH |  | DFND | 1 | 7503812 | 0 | 0 |
| ATRICURE INC | COM | 04963C209 |  | 3086807 | 87569 | SH |  | DFND | 1 | 87569 | 0 | 0 |
| AVANOS MED INC | COM | 05350V106 |  | 1420712 | 122899 | SH |  | DFND | 1 | 122899 | 0 | 0 |
| AZENTA INC | COM | 114340102 |  | 1177635 | 41004 | SH |  | DFND | 1 | 41004 | 0 | 0 |
| BAXTER INTL INC | COM | 071813109 |  | 973281 | 42744 | SH |  | DFND | 1 | 42744 | 0 | 0 |
| BELLRING BRANDS INC | COMMON STOCK | 07831C103 |  | 1244333 | 34232 | SH |  | DFND | 1 | 34232 | 0 | 0 |
| BETA BIONICS INC | COM | 08659B102 |  | 23216406 | 1168415 | SH |  | DFND | 1 | 1168415 | 0 | 0 |
| BIO RAD LABS INC | CL A | 090572207 |  | 63387767 | 226070 | SH |  | DFND | 1 | 226070 | 0 | 0 |
| BIOCRYST PHARMACEUTICALS INC | COM | 09058V103 |  | 92362710 | 12169000 | SH |  | DFND | 1 | 12169000 | 0 | 0 |
| BIOLIFE SOLUTIONS INC | COM NEW | 09062W204 |  | 2836584 | 111195 | SH |  | DFND | 1 | 111195 | 0 | 0 |
| BIOMX INC | COM NEW | 09090D301 |  | 1309407 | 2494108 | SH |  | DFND | 1 | 2494108 | 0 | 0 |
| BIO-TECHNE CORP | COM | 09073M104 |  | 1167062 | 20979 | SH |  | DFND | 1 | 20979 | 0 | 0 |
| BOSTON SCIENTIFIC CORP | COM | 101137107 |  | 3056991 | 31312 | SH |  | DFND | 1 | 31312 | 0 | 0 |
| BRIDGEBIO ONCOLOGY THERAPEUT | COM | 107924102 |  | 56573465 | 4885446 | SH |  | DFND | 1 | 4885446 | 0 | 0 |
| BRISTOL-MYERS SQUIBB CO | COM | 110122108 |  | 105433472 | 2337771 | SH |  | DFND | 1 | 2337771 | 0 | 0 |
| BROOKDALE SR LIVING INC | COM | 112463104 |  | 98604708 | 11641642 | SH |  | DFND | 1 | 11641642 | 0 | 0 |
| BUTTERFLY NETWORK INC | *W EXP 02/12/202 | 124155110 |  | 33440 | 733333 | SH |  | DFND | 1 | 733333 | 0 | 0 |
| CALCIMEDICA INC | COM NEW | 38942Q202 |  | 3998540 | 1300000 | SH |  | DFND | 1 | 1300000 | 0 | 0 |
| CAREDX INC | COM | 14167L103 |  | 31857140 | 2191000 | SH |  | DFND | 1 | 2191000 | 0 | 0 |
| CATALYST PHARMACEUTICALS INC | COM | 14888U101 |  | 98002910 | 4974767 | SH |  | DFND | 1 | 4974767 | 0 | 0 |
| CELCUITY INC | COM | 15102K100 |  | 36236382 | 733530 | SH |  | DFND | 1 | 733530 | 0 | 0 |
| CENTENE CORP DEL | COM | 15135B101 |  | 322761280 | 9046000 | SH |  | DFND | 1 | 9046000 | 0 | 0 |
| CERTARA INC | COM | 15687V109 |  | 82357142 | 6739537 | SH |  | DFND | 1 | 6739537 | 0 | 0 |
| CHEMED CORP NEW | COM | 16359R103 |  | 2088259 | 4664 | SH |  | DFND | 1 | 4664 | 0 | 0 |
| COGENT BIOSCIENCES INC | COM | 19240Q201 |  | 130002774 | 9053118 | SH |  | DFND | 1 | 9053118 | 0 | 0 |
| COMMUNITY HEALTH SYS INC NEW | COM | 203668108 |  | 105031 | 32720 | SH |  | DFND | 1 | 32720 | 0 | 0 |
| CONMED CORP | COM | 207410101 |  | 35752018 | 760196 | SH |  | DFND | 1 | 760196 | 0 | 0 |
| COOPER COS INC | COM | 216648501 |  | 2955622 | 43110 | SH |  | DFND | 1 | 43110 | 0 | 0 |
| CORMEDIX INC | COM | 21900C308 |  | 38656178 | 3323833 | SH |  | DFND | 1 | 3323833 | 0 | 0 |
| CORVEL CORP | COM | 221006109 |  | 2339323 | 30216 | SH |  | DFND | 1 | 30216 | 0 | 0 |
| CULLINAN THERAPEUTICS INC | COM | 230031106 |  | 17357187 | 2927013 | SH |  | DFND | 1 | 2927013 | 0 | 0 |
| DANAHER CORPORATION | COM | 235851102 |  | 1273027 | 6421 | SH |  | DFND | 1 | 6421 | 0 | 0 |
| DAVITA INC | COM | 23918K108 |  | 2466997 | 18567 | SH |  | DFND | 1 | 18567 | 0 | 0 |
| DAY ONE BIOPHARMACEUTICALS I | COM | 23954D109 |  | 33173162 | 4705413 | SH |  | DFND | 1 | 4705413 | 0 | 0 |
| DENTSPLY SIRONA INC | COM | 24906P109 |  | 383022 | 30183 | SH |  | DFND | 1 | 30183 | 0 | 0 |
| DEXCOM INC | COM | 252131107 |  | 1499692 | 22287 | SH |  | DFND | 1 | 22287 | 0 | 0 |
| DISC MEDICINE INC | COM | 254604101 |  | 60754150 | 919403 | SH |  | DFND | 1 | 919403 | 0 | 0 |
| DOCGO INC | COM | 256086109 |  | 6286883 | 4622708 | SH |  | DFND | 1 | 4622708 | 0 | 0 |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 |  | 12419557 | 765694 | SH |  | DFND | 1 | 765694 | 0 | 0 |
| EDWARDS LIFESCIENCES CORP | COM | 28176E108 |  | 493762 | 6349 | SH |  | DFND | 1 | 6349 | 0 | 0 |
| ELUTIA INC | CL A COM | 05479K106 |  | 1221001 | 1371603 | SH |  | DFND | 1 | 1371603 | 0 | 0 |
| EMBECTA CORP | COMMON STOCK | 29082K105 |  | 36974140 | 2620421 | SH |  | DFND | 1 | 2620421 | 0 | 0 |
| EMERGENT BIOSOLUTIONS INC | COM | 29089Q105 |  | 16511 | 1872 | SH |  | DFND | 1 | 1872 | 0 | 0 |
| ENHABIT INC | COM | 29332G102 |  | 38029445 | 4747746 | SH |  | DFND | 1 | 4747746 | 0 | 0 |
| ENOVIS CORPORATION | COM | 194014502 |  | 2099922 | 69213 | SH |  | DFND | 1 | 69213 | 0 | 0 |
| ENVISTA HOLDINGS CORPORATION | COM | 29415F104 |  | 46729513 | 2294036 | SH |  | DFND | 1 | 2294036 | 0 | 0 |
| FOGHORN THERAPEUTICS INC | COM | 344174107 |  | 15919463 | 3255514 | SH |  | DFND | 1 | 3255514 | 0 | 0 |
| GE HEALTHCARE TECHNOLOGIES I | COMMON STOCK | 36266G107 |  | 1646492 | 21924 | SH |  | DFND | 1 | 21924 | 0 | 0 |
| GLOBUS MED INC | CL A | 379577208 |  | 636041 | 11106 | SH |  | DFND | 1 | 11106 | 0 | 0 |
| HAEMONETICS CORP MASS | COM | 405024100 |  | 3367398 | 69089 | SH |  | DFND | 1 | 69089 | 0 | 0 |
| HEALTHEQUITY INC | COM | 42226A107 |  | 669076 | 7060 | SH |  | DFND | 1 | 7060 | 0 | 0 |
| HEARTFLOW INC | COM | 42238D107 |  | 3366000 | 100000 | SH |  | DFND | 1 | 100000 | 0 | 0 |
| HENRY SCHEIN INC | COM | 806407102 |  | 278157 | 4191 | SH |  | DFND | 1 | 4191 | 0 | 0 |
| HUMANA INC | COM | 444859102 |  | 238576 | 917 | SH |  | DFND | 1 | 917 | 0 | 0 |
| IDEAYA BIOSCIENCES INC | COM | 45166A102 |  | 58584300 | 2153043 | SH |  | DFND | 1 | 2153043 | 0 | 0 |
| IMMUNOCORE HLDGS PLC | NOTE 2.500% 2/0 | 45258DAB1 |  | 27040830 | 30000000 | PRN |  | DFND | 1 | 30000000 | 0 | 0 |
| INDIVIOR PLC | ORD | G4766E116 |  | 168452013 | 6986811 | SH |  | DFND | 1 | 6986811 | 0 | 0 |
| INSMED INC | COM PAR $.01 | 457669307 |  | 67828710 | 471000 | SH |  | DFND | 1 | 471000 | 0 | 0 |
| INSPIRE MED SYS INC | COM | 457730109 |  | 77738895 | 1047694 | SH |  | DFND | 1 | 1047694 | 0 | 0 |
| INSULET CORP | COM | 45784P101 |  | 1383110 | 4480 | SH |  | DFND | 1 | 4480 | 0 | 0 |
| INTEGER HLDGS CORP | COM | 45826H109 |  | 1294518 | 12528 | SH |  | DFND | 1 | 12528 | 0 | 0 |
| INTEGRA LIFESCIENCES HLDGS C | COM NEW | 457985208 |  | 11390415 | 794865 | SH |  | DFND | 1 | 794865 | 0 | 0 |
| INTUITIVE SURGICAL INC | COM NEW | 46120E602 |  | 2432037 | 5438 | SH |  | DFND | 1 | 5438 | 0 | 0 |
| IONIS PHARMACEUTICALS INC | NOTE 1.750% 6/1 | 462222AF7 |  | 82657920 | 60000000 | PRN |  | DFND | 1 | 60000000 | 0 | 0 |
| IONIS PHARMACEUTICALS INC | COM | 462222100 |  | 129509946 | 1979669 | SH |  | DFND | 1 | 1979669 | 0 | 0 |
| IRHYTHM TECHNOLOGIES INC | COM | 450056106 |  | 2968891 | 17262 | SH |  | DFND | 1 | 17262 | 0 | 0 |
| JADE BIOSCIENCES INC | COM NEW | 008064206 |  | 4583937 | 531163 | SH |  | DFND | 1 | 531163 | 0 | 0 |
| KENVUE INC | COM | 49177J102 |  | 3146234 | 193853 | SH |  | DFND | 1 | 193853 | 0 | 0 |
| KYMERA THERAPEUTICS INC | COM | 501575104 |  | 32389803 | 572258 | SH |  | DFND | 1 | 572258 | 0 | 0 |
| LABCORP HOLDINGS INC | COM SHS | 504922105 |  | 303422 | 1057 | SH |  | DFND | 1 | 1057 | 0 | 0 |
| LANTHEUS HLDGS INC | NOTE 2.625%12/1 | 516544AB9 |  | 26532954 | 25255000 | PRN |  | DFND | 1 | 25255000 | 0 | 0 |
| LARIMAR THERAPEUTICS INC | COM | 517125100 |  | 98860526 | 30606974 | SH |  | DFND | 1 | 30606974 | 0 | 0 |
| LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 |  | 96601842 | 2962338 | SH |  | DFND | 1 | 2962338 | 0 | 0 |
| LEMAITRE VASCULAR INC | COM | 525558201 |  | 2621712 | 29959 | SH |  | DFND | 1 | 29959 | 0 | 0 |
| LIVANOVA PLC | NOTE 2.500% 3/1 | 53802LAB8 |  | 36861421 | 34280000 | PRN |  | DFND | 1 | 34280000 | 0 | 0 |
| MERCK  CO INC | COM | 58933Y105 |  | 86447900 | 1030000 | SH |  | DFND | 1 | 1030000 | 0 | 0 |
| MERIT MED SYS INC | COM | 589889104 |  | 3482843 | 41846 | SH |  | DFND | 1 | 41846 | 0 | 0 |
| MERUS N V | COM | N5749R100 |  | 286867141 | 3046916 | SH |  | DFND | 1 | 3046916 | 0 | 0 |
| MIMEDX GROUP INC | COM | 602496101 |  | 731993 | 104870 | SH |  | DFND | 1 | 104870 | 0 | 0 |
| MIRUM PHARMACEUTICALS INC | NOTE 4.000% 5/0 | 604749AB7 |  | 168190750 | 70000000 | PRN |  | DFND | 1 | 70000000 | 0 | 0 |
| MODERNA INC | COM | 60770K107 |  | 25830000 | 1000000 | SH | Put | DFND | 1 | 1000000 | 0 | 0 |
| MOLINA HEALTHCARE INC | COM | 60855R100 |  | 965794 | 5047 | SH |  | DFND | 1 | 5047 | 0 | 0 |
| MONOPAR THERAPEUTICS INC | COM NEW | 61023L207 |  | 13048008 | 159765 | SH |  | DFND | 1 | 159765 | 0 | 0 |
| MYRIAD GENETICS INC | COM | 62855J104 |  | 3651 | 505 | SH |  | DFND | 1 | 505 | 0 | 0 |
| NATIONAL HEALTHCARE CORP | COM | 635906100 |  | 1772102 | 14584 | SH |  | DFND | 1 | 14584 | 0 | 0 |
| NEOGENOMICS INC | COM NEW | 64049M209 |  | 34333395 | 4447331 | SH |  | DFND | 1 | 4447331 | 0 | 0 |
| NEOGENOMICS INC | NOTE 0.250% 1/1 | 64049MAB6 |  | 62922579 | 72689000 | PRN |  | DFND | 1 | 72689000 | 0 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 |  | 166258351 | 1184345 | SH |  | DFND | 1 | 1184345 | 0 | 0 |
| NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | N62509109 |  | 121344749 | 4266693 | SH |  | DFND | 1 | 4266693 | 0 | 0 |
| NEWAMSTERDAM PHARMA COMPANY | *W EXP 99/99/999 | N62509117 |  | 1587586 | 92787 | SH |  | DFND | 1 | 92787 | 0 | 0 |
| NUVALENT INC | COM | 670703107 |  | 1555863756 | 17991024 | SH |  | DFND | 1 | 17991024 | 0 | 0 |
| NUVATION BIO INC | *W EXP 02/10/202 | 67080N119 |  | 33683 | 166666 | SH |  | DFND | 1 | 166666 | 0 | 0 |
| OMADA HEALTH INC | COM | 68170A108 |  | 12229196 | 553107 | SH |  | DFND | 1 | 553107 | 0 | 0 |
| ORGANON  CO | COMMON STOCK | 68622V106 |  | 175024 | 16388 | SH |  | DFND | 1 | 16388 | 0 | 0 |
| ORTHOPEDIATRICS CORP | COM | 68752L100 |  | 3596840 | 194109 | SH |  | DFND | 1 | 194109 | 0 | 0 |
| PENUMBRA INC | COM | 70975L107 |  | 1624035 | 6411 | SH |  | DFND | 1 | 6411 | 0 | 0 |
| PFIZER INC | COM | 717081103 |  | 84180569 | 3303790 | SH |  | DFND | 1 | 3303790 | 0 | 0 |
| PHARVARIS N V | COM | N69605108 |  | 60939477 | 2442464 | SH |  | DFND | 1 | 2442464 | 0 | 0 |
| PHREESIA INC | COM | 71944F106 |  | 26266007 | 1116752 | SH |  | DFND | 1 | 1116752 | 0 | 0 |
| PMV PHARMACEUTICALS INC | COM | 69353Y103 |  | 12306 | 8790 | SH |  | DFND | 1 | 8790 | 0 | 0 |
| PRAXIS PRECISION MEDICINES I | COM NEW | 74006W207 |  | 44565103 | 840851 | SH |  | DFND | 1 | 840851 | 0 | 0 |
| PRESTIGE CONSMR HEALTHCARE I | COM | 74112D101 |  | 4028731 | 64563 | SH |  | DFND | 1 | 64563 | 0 | 0 |
| QUANTUM SI INC | *W EXP 06/10/202 | 74765K113 |  | 90000 | 333333 | SH |  | DFND | 1 | 333333 | 0 | 0 |
| RADNET INC | COM | 750491102 |  | 3041770 | 39913 | SH |  | DFND | 1 | 39913 | 0 | 0 |
| REPLIGEN CORP | COM | 759916109 |  | 1725546 | 12909 | SH |  | DFND | 1 | 12909 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 170470971 | 3650342 | SH |  | DFND | 1 | 3650342 | 0 | 0 |
| REVVITY INC | COM | 714046109 |  | 2939869 | 33541 | SH |  | DFND | 1 | 33541 | 0 | 0 |
| SAVARA INC | COM | 805111101 |  | 28431480 | 7964000 | SH |  | DFND | 1 | 7964000 | 0 | 0 |
| SERVICE CORP INTL | COM | 817565104 |  | 302505 | 3635 | SH |  | DFND | 1 | 3635 | 0 | 0 |
| SHOULDER INNOVATIONS INC | COMMON STOCK | 82537J108 |  | 6056279 | 482572 | SH |  | DFND | 1 | 482572 | 0 | 0 |
| SIONNA THERAPEUTICS INC | COM | 829401108 |  | 28545052 | 970590 | SH |  | DFND | 1 | 970590 | 0 | 0 |
| SOTERA HEALTH CO | COM | 83601L102 |  | 399290 | 25384 | SH |  | DFND | 1 | 25384 | 0 | 0 |
| SPYRE THERAPEUTICS INC | COM NEW | 00773J202 |  | 10285025 | 613665 | SH |  | DFND | 1 | 613665 | 0 | 0 |
| STAAR SURGICAL CO | COM PAR $0.01 | 852312305 |  | 2606094 | 96989 | SH |  | DFND | 1 | 96989 | 0 | 0 |
| STERIS PLC | SHS USD | G8473T100 |  | 637900 | 2578 | SH |  | DFND | 1 | 2578 | 0 | 0 |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 |  | 10455396 | 373407 | SH |  | DFND | 1 | 373407 | 0 | 0 |
| STRYKER CORPORATION | COM | 863667101 |  | 734904 | 1988 | SH |  | DFND | 1 | 1988 | 0 | 0 |
| SUPERNUS PHARMACEUTICALS INC | COM | 868459108 |  | 254768 | 5331 | SH |  | DFND | 1 | 5331 | 0 | 0 |
| SURROZEN INC | *W EXP 08/01/203 | 86889P117 |  | 2967 | 166666 | SH |  | DFND | 1 | 166666 | 0 | 0 |
| TANDEM DIABETES CARE INC | NOTE 1.500% 3/1 | 875372AD6 |  | 87142700 | 100000000 | PRN |  | DFND | 1 | 100000000 | 0 | 0 |
| TANDEM DIABETES CARE INC | COM NEW | 875372203 |  | 148047 | 12195 | SH |  | DFND | 1 | 12195 | 0 | 0 |
| TAYSHA GENE THERAPIES INC | COM SHS | 877619106 |  | 17612220 | 5386000 | SH |  | DFND | 1 | 5386000 | 0 | 0 |
| TELEFLEX INCORPORATED | COM | 879369106 |  | 1660670 | 13572 | SH |  | DFND | 1 | 13572 | 0 | 0 |
| THE ONCOLOGY INSTITUTE INC | *W EXP 99/99/999 | 68236X118 |  | 150000 | 1250000 | SH |  | DFND | 1 | 1250000 | 0 | 0 |
| THE ONCOLOGY INSTITUTE INC | COM | 68236X100 |  | 11726581 | 3360052 | SH |  | DFND | 1 | 3360052 | 0 | 0 |
| THERMO FISHER SCIENTIFIC INC | COM | 883556102 |  | 457859 | 944 | SH |  | DFND | 1 | 944 | 0 | 0 |
| TRANSMEDICS GROUP INC | COM | 89377M109 |  | 1430774 | 12752 | SH |  | DFND | 1 | 12752 | 0 | 0 |
| TRUPANION INC | COM | 898202106 |  | 2468908 | 57045 | SH |  | DFND | 1 | 57045 | 0 | 0 |
| TWIST BIOSCIENCE CORP | COM | 90184D100 |  | 670492 | 23827 | SH |  | DFND | 1 | 23827 | 0 | 0 |
| UFP TECHNOLOGIES INC | COM | 902673102 |  | 3724536 | 18660 | SH |  | DFND | 1 | 18660 | 0 | 0 |
| UNITED THERAPEUTICS CORP DEL | COM | 91307C102 |  | 178580526 | 425993 | SH |  | DFND | 1 | 425993 | 0 | 0 |
| VAREX IMAGING CORP | COM | 92214X106 |  | 3536567 | 285207 | SH |  | DFND | 1 | 285207 | 0 | 0 |
| VENTAS INC | COM | 92276F100 |  | 24776460 | 354000 | SH |  | DFND | 1 | 354000 | 0 | 0 |
| VERA THERAPEUTICS INC | CL A | 92337R101 |  | 105812022 | 3641157 | SH |  | DFND | 1 | 3641157 | 0 | 0 |
| VERACYTE INC | COM | 92337F107 |  | 24923580 | 726000 | SH |  | DFND | 1 | 726000 | 0 | 0 |
| VIATRIS INC | COM | 92556V106 |  | 238580922 | 24099083 | SH |  | DFND | 1 | 24099083 | 0 | 0 |
| WATERS CORP | COM | 941848103 |  | 2364002 | 7885 | SH |  | DFND | 1 | 7885 | 0 | 0 |
| XENON PHARMACEUTICALS INC | COM | 98420N105 |  | 21762103 | 542020 | SH |  | DFND | 1 | 542020 | 0 | 0 |
| XERIS BIOPHARMA HOLDINGS INC | COM | 98422E103 |  | 984126 | 120900 | SH |  | DFND | 1 | 120900 | 0 | 0 |
| ZENAS BIOPHARMA INC | COM | 98937L105 |  | 34697312 | 1562942 | SH |  | DFND | 1 | 1562942 | 0 | 0 |
| ZOETIS INC | CL A | 98978V103 |  | 1251621 | 8554 | SH |  | DFND | 1 | 8554 | 0 | 0 |

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