# EDGAR Filing Document

**Accession Number:** 0001100663
**File Stem:** 0001752724-25-210361
**Filing Date:** 2025-8
**Character Count:** 94937
**Document Hash:** c2c0213799d6a11351ef375087b110fd
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001752724-25-210361.hdr.sgml**: 20250828

**ACCESSION NUMBER**: 0001752724-25-210361

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20250630

**FILED AS OF DATE**: 20250828

**DATE AS OF CHANGE**: 20250828

**PERIOD START**: 20260331

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** iSHARES TRUST
- **CENTRAL INDEX KEY:** 0001100663

**ORGANIZATION NAME:**
- **EIN:** 943351276
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-09729
- **FILM NUMBER:** 251268865

**BUSINESS ADDRESS:**
- **STREET 1:** 400 HOWARD STREET
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94105
- **BUSINESS PHONE:** (415) 670-2000

**MAIL ADDRESS:**
- **STREET 1:** 400 HOWARD STREET
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94105

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ISHARES TRUST
- **DATE OF NAME CHANGE:** 19991213

## Series and Classes Contracts Data

### iShares Biotechnology ETF (Series ID: S000004350)

| Class ID   | Class Name                | Ticker Symbol   |
|:---|:---|:---|
| C000012080 | iShares Biotechnology ETF | IBB             |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** iShares Trust

- **b. Investment Company Act file number:** 811-09729

- **c. CIK number of Registrant:** 0001100663

- **d. LEI of Registrant:** 5493000860OXIC4B5K91

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 400 Howard Street

  - **City:** San Francisco

  - **State:** CA

  - **Foreign country:** US

  - **Zip / Postal Code:** 94105

  - **Telephone number:** 800-474-2737

**Item A.2. Information about the Series.**

- **a. Name of Series:** iShares Biotechnology ETF

- **b. EDGAR series identifier (if any):** S000004350

- **c. LEI of Series:** 549300S7IVD88MPK0066

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2026-03-31

- **b. Date as of which information is reported:** 2025-06-30

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $5979286391.73

**Total Liabilities:** $701475265.50

**Net Assets:** $5277811126.23

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000012080 | -0.92%               | -3.91%               | 3.94%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $88823109.19             | $-137282682.32                             |
| Month 2  | $32235351.28             | $-252468263.22                             |
| Month 3  | $4757567.85              | $188643550.98                              |

**Designated Index Information**

- **Index Name:** N/A

- **Index Identifier:** N/A

### Schedule of Portfolio Investments

| Name                                           | Title                                                 | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Applied Therapeutics, Inc.                     | Applied Therapeutics, Inc.                            | CUSIP: 03828A101<br>LEI: 549300KL3IJPHZM2GR04 | Long             | EC               | CORP              | US        |    769010 | NS      | $239239.01    | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| MannKind Corp.                                 | MannKind Corp.                                        | CUSIP: 56400P706<br>LEI: 213800GFBCNY1ZFST722 | Long             | EC               | CORP              | US        |   1824026 | NS      | $6821857.24   | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Neurogene, Inc.                                | Neurogene, Inc.                                       | CUSIP: 64135M105<br>LEI: 529900A7VIY892SZVW73 | Long             | EC               | CORP              | US        |     70713 | NS      | $1057159.35   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Apogee Therapeutics, Inc.                      | Apogee Therapeutics, Inc.                             | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    231160 | NS      | $10039278.80  | 0.19%             |  |  |  | No            |                  1 | On Loan: —       |
| Enliven Therapeutics, Inc.                     | Enliven Therapeutics, Inc.                            | CUSIP: 29337E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    199555 | NS      | $4003073.30   | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Bicycle Therapeutics plc                       | Bicycle Therapeutics plc                              | CUSIP: 088786108<br>LEI: 213800XKUI6R7GKC3E43 | Long             | EC               | CORP              | GB        |    166268 | NS      | $1155562.60   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Ionis Pharmaceuticals, Inc.                    | Ionis Pharmaceuticals, Inc.                           | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |    962052 | NS      | $38010674.52  | 0.72%             |  |  |  | No            |                  1 | On Loan: —       |
| United Therapeutics Corp.                      | United Therapeutics Corp.                             | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |    272527 | NS      | $78310633.45  | 1.48%             |  |  |  | No            |                  1 | On Loan: No      |
| Solid Biosciences, Inc.                        | Solid Biosciences, Inc.                               | CUSIP: 83422E204<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    350637 | NS      | $1707602.19   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| uniQure NV                                     | uniQure NV                                            | CUSIP: N/A<br>LEI: 724500RPCTZLFYJZ3S98       | Long             | EC               | CORP              | NL        |    307776 | NS      | $4290397.44   | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| ORIC Pharmaceuticals, Inc.                     | ORIC Pharmaceuticals, Inc.                            | CUSIP: 68622P109<br>LEI: 54930033FJRNEYBW0L25 | Long             | EC               | CORP              | US        |    267567 | NS      | $2715805.05   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Tango Therapeutics, Inc.                       | Tango Therapeutics, Inc.                              | CUSIP: 87583X109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    365088 | NS      | $1869250.56   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Madrigal Pharmaceuticals, Inc.                 | Madrigal Pharmaceuticals, Inc.                        | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |    124440 | NS      | $37660521.60  | 0.71%             |  |  |  | No            |                  1 | On Loan: —       |
| 4D Molecular Therapeutics, Inc.                | 4D Molecular Therapeutics, Inc.                       | CUSIP: 35104E100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    257434 | NS      | $955080.14    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Savara, Inc.                                   | Savara, Inc.                                          | CUSIP: 805111101<br>LEI: 5493002JO0WM3YMJXG33 | Long             | EC               | CORP              | US        |    484533 | NS      | $1104735.24   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Stoke Therapeutics, Inc.                       | Stoke Therapeutics, Inc.                              | CUSIP: 86150R107<br>LEI: 549300RD25SS2DIJHJ67 | Long             | EC               | CORP              | US        |    261425 | NS      | $2967173.75   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| BioMarin Pharmaceutical, Inc.                  | BioMarin Pharmaceutical, Inc.                         | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |   1171370 | NS      | $64390208.90  | 1.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Lexeo Therapeutics, Inc.                       | Lexeo Therapeutics, Inc.                              | CUSIP: 52886X107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    150643 | NS      | $605584.86    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Cybin, Inc.                                    | Cybin, Inc.                                           | CUSIP: 23256X407<br>LEI: 549300NTYWN4CVYSCN32 | Long             | EC               | CORP              | CA        |    116130 | NS      | $974330.70    | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Kymera Therapeutics, Inc.                      | Kymera Therapeutics, Inc.                             | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    329748 | NS      | $14390202.72  | 0.27%             |  |  |  | No            |                  1 | On Loan: —       |
| Alumis, Inc.                                   | Alumis, Inc.                                          | CUSIP: 022307102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    418196 | NS      | $1254588.00   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Merus NV                                       | Merus NV                                              | CUSIP: N/A<br>LEI: 549300W8GPUWU8QNU293       | Long             | EC               | CORP              | NL        |    381821 | NS      | $20083784.60  | 0.38%             |  |  |  | No            |                  1 | On Loan: —       |
| 89bio, Inc.                                    | 89bio, Inc.                                           | CUSIP: 282559103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    875426 | NS      | $8596683.32   | 0.16%             |  |  |  | No            |                  1 | On Loan: —       |
| Waters Corp.                                   | Waters Corp.                                          | CUSIP: 941848103<br>LEI: 5T547R1474YC9HOD8Q74 | Long             | EC               | CORP              | US        |    367929 | NS      | $128421938.16 | 2.43%             |  |  |  | No            |                  1 | On Loan: —       |
| Fusion Pharmaceuticals, Inc.                   | Fusion Pharmaceuticals, Inc., CVR                     | CUSIP: 361CVR012<br>LEI: N/A                  | Long             |  | CORP              | CA        |      1880 | NS      | $1034.00      | 0.00%             |  |  |  | No            |                  2 | On Loan: —       |
| Amylyx Pharmaceuticals, Inc.                   | Amylyx Pharmaceuticals, Inc.                          | CUSIP: 03237H101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    404655 | NS      | $2593838.55   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Mineralys Therapeutics, Inc.                   | Mineralys Therapeutics, Inc.                          | CUSIP: 603170101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    250880 | NS      | $3394406.40   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Medpace Holdings, Inc.                         | Medpace Holdings, Inc.                                | CUSIP: 58506Q109<br>LEI: 549300H8TYEUVTW14A54 | Long             | EC               | CORP              | US        |    144464 | NS      | $45341471.04  | 0.86%             |  |  |  | No            |                  1 | On Loan: —       |
| Repligen Corp.                                 | Repligen Corp.                                        | CUSIP: 759916109<br>LEI: 54930006QJ0T5AUO1E71 | Long             | EC               | CORP              | US        |    329093 | NS      | $40932587.34  | 0.78%             |  |  |  | No            |                  1 | On Loan: —       |
| Neurocrine Biosciences, Inc.                   | Neurocrine Biosciences, Inc.                          | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |    591490 | NS      | $74344378.10  | 1.41%             |  |  |  | No            |                  1 | On Loan: No      |
| MeiraGTx Holdings plc                          | MeiraGTx Holdings plc                                 | CUSIP: N/A<br>LEI: 54930007YV6NYIOGFZ57       | Long             | EC               | CORP              | KY        |    335210 | NS      | $2185569.20   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Absci Corp.                                    | Absci Corp.                                           | CUSIP: 00091E109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    690672 | NS      | $1775027.04   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Insmed, Inc.                                   | Insmed, Inc.                                          | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |   1102662 | NS      | $110971903.68 | 2.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Dyne Therapeutics, Inc.                        | Dyne Therapeutics, Inc.                               | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    528095 | NS      | $5027464.40   | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| Vera Therapeutics, Inc.                        | Vera Therapeutics, Inc., Class A                      | CUSIP: 92337R101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    297813 | NS      | $7016474.28   | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Rhythm Pharmaceuticals, Inc.                   | Rhythm Pharmaceuticals, Inc.                          | CUSIP: 76243J105<br>LEI: 529900JPNWXQ8DPLA551 | Long             | EC               | CORP              | US        |    360760 | NS      | $22796424.40  | 0.43%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen, Inc.                                   | Biogen, Inc.                                          | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |    906299 | NS      | $113822091.41 | 2.16%             |  |  |  | No            |                  1 | On Loan: —       |
| OmniAb, Inc.                                   | OmniAb, Inc., 15.00 Earnout Shares                    | CUSIP: 68218J301<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     46839 | NS      | $0.47         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Design Therapeutics, Inc.                      | Design Therapeutics, Inc.                             | CUSIP: 25056L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    186112 | NS      | $627197.44    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Kura Oncology, Inc.                            | Kura Oncology, Inc.                                   | CUSIP: 50127T109<br>LEI: 5493005QORQTZCZYOP39 | Long             | EC               | CORP              | US        |    509869 | NS      | $2941944.13   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Mettler-Toledo International, Inc.             | Mettler-Toledo International, Inc.                    | CUSIP: 592688105<br>LEI: 5493000BD5GJNUDIUG10 | Long             | EC               | CORP              | US        |    128198 | NS      | $150596754.56 | 2.85%             |  |  |  | No            |                  1 | On Loan: —       |
| Tarsus Pharmaceuticals, Inc.                   | Tarsus Pharmaceuticals, Inc.                          | CUSIP: 87650L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    224637 | NS      | $9100044.87   | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Charles River Laboratories International, Inc. | Charles River Laboratories International, Inc.        | CUSIP: 159864107<br>LEI: 549300BSQ0R4UZ5KX287 | Long             | EC               | CORP              | US        |    300854 | NS      | $45648577.42  | 0.86%             |  |  |  | No            |                  1 | On Loan: —       |
| Nurix Therapeutics, Inc.                       | Nurix Therapeutics, Inc.                              | CUSIP: 67080M103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    462916 | NS      | $5272613.24   | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| Pliant Therapeutics, Inc.                      | Pliant Therapeutics, Inc.                             | CUSIP: 729139105<br>LEI: 5493002Q5LITR7VHZH02 | Long             | EC               | CORP              | US        |    336376 | NS      | $390196.16    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Phathom Pharmaceuticals, Inc.                  | Phathom Pharmaceuticals, Inc.                         | CUSIP: 71722W107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    234942 | NS      | $2253093.78   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Entrada Therapeutics, Inc.                     | Entrada Therapeutics, Inc.                            | CUSIP: 29384C108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    139043 | NS      | $934368.96    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Alpha Teknova, Inc.                            | Alpha Teknova, Inc.                                   | CUSIP: 02080L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     69012 | NS      | $338848.92    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Editas Medicine, Inc.                          | Editas Medicine, Inc.                                 | CUSIP: 28106W103<br>LEI: 5299000AON4Q9NT2JE42 | Long             | EC               | CORP              | US        |    518495 | NS      | $1140689.00   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Ironwood Pharmaceuticals, Inc.                 | Ironwood Pharmaceuticals, Inc., Class A               | CUSIP: 46333X108<br>LEI: 549300PC8MR6QHH6P296 | Long             | EC               | CORP              | US        |    920722 | NS      | $660341.82    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Allogene Therapeutics, Inc.                    | Allogene Therapeutics, Inc.                           | CUSIP: 019770106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    926172 | NS      | $1046574.36   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Edgewise Therapeutics, Inc.                    | Edgewise Therapeutics, Inc.                           | CUSIP: 28036F105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    477691 | NS      | $6262529.01   | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Argenx SE                                      | Argenx SE                                             | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |    238473 | NS      | $131451087.06 | 2.49%             |  |  |  | No            |                  1 | On Loan: —       |
| BlackRock Funds III                            | BlackRock Cash Funds: Institutional, SL Agency Shares | CUSIP: 066922519<br>LEI: 549300JDHS1T46VWOG19 | Long             | STIV             | RF                | US        | 697694927 | NS      | $697974005.17 | 13.22%            |  |  |  | No            |                  1 | On Loan: No      |
| Aura Biosciences, Inc.                         | Aura Biosciences, Inc.                                | CUSIP: 05153U107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    289760 | NS      | $1813897.60   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| SpringWorks Therapeutics, Inc.                 | SpringWorks Therapeutics, Inc.                        | CUSIP: 85205L107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    455747 | NS      | $21415551.53  | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Genmab A/S                                     | Genmab A/S                                            | CUSIP: 372303206<br>LEI: 529900MTJPDPE4MHJ122 | Long             | EC               | CORP              | DK        |   2512991 | NS      | $51918394.06  | 0.98%             |  |  |  | No            |                  1 | On Loan: —       |
| Recursion Pharmaceuticals, Inc.                | Recursion Pharmaceuticals, Inc., Class A              | CUSIP: 75629V104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1925610 | NS      | $9743586.60   | 0.18%             |  |  |  | No            |                  1 | On Loan: —       |
| Zai Lab Ltd.                                   | Zai Lab Ltd.                                          | CUSIP: 98887Q104<br>LEI: 549300P2UYQ9U5LY1T58 | Long             | EC               | CORP              | KY        |    426733 | NS      | $14922853.01  | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Olema Pharmaceuticals, Inc.                    | Olema Pharmaceuticals, Inc.                           | CUSIP: 68062P106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    324084 | NS      | $1380597.84   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Revolution Medicines, Inc.                     | Revolution Medicines, Inc.                            | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |   1003275 | NS      | $36910487.25  | 0.70%             |  |  |  | No            |                  1 | On Loan: —       |
| Blueprint Medicines Corp.                      | Blueprint Medicines Corp.                             | CUSIP: 09627Y109<br>LEI: 5299004CC60O9T5HVM83 | Long             | EC               | CORP              | US        |    385450 | NS      | $49406981.00  | 0.94%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                            | Russell 2000 E-Mini Index                             | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |        30 | NC      | $50468.58     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Standard BioTools, Inc.                        | Standard BioTools, Inc.                               | CUSIP: 34385P108<br>LEI: 549300GX8Y96GSB6YP89 | Long             | EC               | CORP              | US        |   2267026 | NS      | $2720431.20   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| MacroGenics, Inc.                              | MacroGenics, Inc.                                     | CUSIP: 556099109<br>LEI: 5493001KJQUA83L8MH79 | Long             | EC               | CORP              | US        |    353277 | NS      | $427465.17    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| 10X Genomics, Inc.                             | 10X Genomics, Inc., Class A                           | CUSIP: 88025U109<br>LEI: 5493003Z6741WNLG7H43 | Long             | EC               | CORP              | US        |    641034 | NS      | $7423173.72   | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| Myriad Genetics, Inc.                          | Myriad Genetics, Inc.                                 | CUSIP: 62855J104<br>LEI: 52990044IHUOUMETT163 | Long             | EC               | CORP              | US        |    543639 | NS      | $2886723.09   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Disc Medicine, Inc.                            | Disc Medicine, Inc.                                   | CUSIP: 254604101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    130583 | NS      | $6915675.68   | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Bio-Techne Corp.                               | Bio-Techne Corp.                                      | CUSIP: 09073M104<br>LEI: 54930073RLKQ51TILZ35 | Long             | EC               | CORP              | US        |    960304 | NS      | $49407640.80  | 0.94%             |  |  |  | No            |                  1 | On Loan: No      |
| Theravance Biopharma, Inc.                     | Theravance Biopharma, Inc.                            | CUSIP: N/A<br>LEI: 5493007VTSXP4Z6MIW52       | Long             | EC               | CORP              | KY        |    284097 | NS      | $3133589.91   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| ADC Therapeutics SA                            | ADC Therapeutics SA                                   | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | CH        |    482736 | NS      | $1293732.48   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Tempus AI, Inc.                                | Tempus AI, Inc.                                       | CUSIP: 88023B103<br>LEI: 2549009LA0KWRAGQBX50 | Long             | EC               | CORP              | US        |    567285 | NS      | $36045288.90  | 0.68%             |  |  |  | No            |                  1 | On Loan: —       |
| Fortrea Holdings, Inc.                         | Fortrea Holdings, Inc.                                | CUSIP: 34965K107<br>LEI: 5493000FIVFABOVCDU97 | Long             | EC               | CORP              | US        |    558513 | NS      | $2759054.22   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| WaVe Life Sciences Ltd.                        | WaVe Life Sciences Ltd.                               | CUSIP: N/A<br>LEI: 54930070006GPKFYZ813       | Long             | EC               | CORP              | SG        |    762635 | NS      | $4957127.50   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Q32 Bio, Inc.                                  | Q32 Bio, Inc.                                         | CUSIP: 746964105<br>LEI: 549300RWKPJEFTM3K452 | Long             | EC               | CORP              | US        |     25366 | NS      | $37795.34     | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| Sage Therapeutics, Inc.                        | Sage Therapeutics, Inc.                               | CUSIP: 78667J108<br>LEI: 5493000JX4BJS9W6CN35 | Long             | EC               | CORP              | US        |    341310 | NS      | $3112747.20   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Ideaya Biosciences, Inc.                       | Ideaya Biosciences, Inc.                              | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |    488084 | NS      | $10259525.68  | 0.19%             |  |  |  | No            |                  1 | On Loan: —       |
| Cytek Biosciences, Inc.                        | Cytek Biosciences, Inc.                               | CUSIP: 23285D109<br>LEI: 549300K2J28BOC6FBO89 | Long             | EC               | CORP              | US        |    706801 | NS      | $2403123.40   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Bruker Corp.                                   | Bruker Corp.                                          | CUSIP: 116794108<br>LEI: LEBZ6VLQ6I8XB1NHVY15 | Long             | EC               | CORP              | US        |    638447 | NS      | $26304016.40  | 0.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Roivant Sciences Ltd.                          | Roivant Sciences Ltd.                                 | CUSIP: N/A<br>LEI: 549300DL466NY5J6U724       | Long             | EC               | CORP              | BM        |   2587755 | NS      | $29163998.85  | 0.55%             |  |  |  | No            |                  1 | On Loan: —       |
| Praxis Precision Medicines, Inc.               | Praxis Precision Medicines, Inc.                      | CUSIP: 74006W207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    112731 | NS      | $4740338.55   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Twist Bioscience Corp.                         | Twist Bioscience Corp.                                | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |    351188 | NS      | $12920206.52  | 0.24%             |  |  |  | No            |                  1 | On Loan: —       |
| Cytokinetics, Inc.                             | Cytokinetics, Inc.                                    | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |    723311 | NS      | $23898195.44  | 0.45%             |  |  |  | No            |                  1 | On Loan: —       |
| Sutro Biopharma, Inc.                          | Sutro Biopharma, Inc.                                 | CUSIP: 869367102<br>LEI: 5493005U6P15VD25P851 | Long             | EC               | CORP              | US        |    489940 | NS      | $349768.17    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Arcturus Therapeutics Holdings, Inc.           | Arcturus Therapeutics Holdings, Inc.                  | CUSIP: 03969T109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    153861 | NS      | $2001731.61   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Illumina, Inc.                                 | Illumina, Inc.                                        | CUSIP: 452327109<br>LEI: SQ95QG8SR5Q56LSNF682 | Long             | EC               | CORP              | US        |    952322 | NS      | $90861042.02  | 1.72%             |  |  |  | No            |                  1 | On Loan: —       |
| Exelixis, Inc.                                 | Exelixis, Inc.                                        | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |   1635340 | NS      | $72077610.50  | 1.37%             |  |  |  | No            |                  1 | On Loan: —       |
| Quanterix Corp.                                | Quanterix Corp.                                       | CUSIP: 74766Q101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    207893 | NS      | $1382488.45   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Prothena Corp. plc                             | Prothena Corp. plc                                    | CUSIP: N/A<br>LEI: 5299009ZXQ8NIIJ8OL30       | Long             | EC               | CORP              | IE        |    257530 | NS      | $1563207.10   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Fate Therapeutics, Inc.                        | Fate Therapeutics, Inc.                               | CUSIP: 31189P102<br>LEI: 549300L14Q4UHOODLA90 | Long             | EC               | CORP              | US        |    663550 | NS      | $743176.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Day One Biopharmaceuticals, Inc.               | Day One Biopharmaceuticals, Inc.                      | CUSIP: 23954D109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    462603 | NS      | $3006919.50   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Galapagos NV                                   | Galapagos NV                                          | CUSIP: 36315X101<br>LEI: 549300QKJ78IY0IOV655 | Long             | EC               | CORP              | BE        |    192794 | NS      | $5396304.06   | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| Replimune Group, Inc.                          | Replimune Group, Inc.                                 | CUSIP: 76029N106<br>LEI: 549300AY704NEIRC4K64 | Long             | EC               | CORP              | US        |    387434 | NS      | $3599261.86   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Janux Therapeutics, Inc.                       | Janux Therapeutics, Inc.                              | CUSIP: 47103J105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    307129 | NS      | $7094679.90   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Centessa Pharmaceuticals plc                   | Centessa Pharmaceuticals plc                          | CUSIP: 152309100<br>LEI: 213800GIDAARDSKOI827 | Long             | EC               | CORP              | GB        |    334669 | NS      | $4397550.66   | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Novocure Ltd.                                  | Novocure Ltd.                                         | CUSIP: N/A<br>LEI: 213800YPP55UMHWA4826       | Long             | EC               | CORP              | JE        |    613457 | NS      | $10919534.60  | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Fulgent Genetics, Inc.                         | Fulgent Genetics, Inc.                                | CUSIP: 359664109<br>LEI: 549300CL6P01M68QJ404 | Long             | EC               | CORP              | US        |    121455 | NS      | $2414525.40   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Castle Biosciences, Inc.                       | Castle Biosciences, Inc.                              | CUSIP: 14843C105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    173136 | NS      | $3535437.12   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Xenon Pharmaceuticals, Inc.                    | Xenon Pharmaceuticals, Inc.                           | CUSIP: 98420N105<br>LEI: 549300XV44Q9Z1MIPQ03 | Long             | EC               | CORP              | CA        |    460879 | NS      | $14425512.70  | 0.27%             |  |  |  | No            |                  1 | On Loan: —       |
| Enanta Pharmaceuticals, Inc.                   | Enanta Pharmaceuticals, Inc.                          | CUSIP: 29251M106<br>LEI: 529900SSN4DODDQSN594 | Long             | EC               | CORP              | US        |    118172 | NS      | $893380.32    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Amicus Therapeutics, Inc.                      | Amicus Therapeutics, Inc.                             | CUSIP: 03152W109<br>LEI: 549300MRD1SMUTNBPQ53 | Long             | EC               | CORP              | US        |   1841912 | NS      | $10554155.76  | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Cullinan Therapeutics, Inc.                    | Cullinan Therapeutics, Inc.                           | CUSIP: 230031106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    222576 | NS      | $1675997.28   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Perspective Therapeutics, Inc.                 | Perspective Therapeutics, Inc.                        | CUSIP: 46489V302<br>LEI: 5493005LRKM6BCABC605 | Long             | EC               | CORP              | US        |    334956 | NS      | $1152248.64   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| PTC Therapeutics, Inc.                         | PTC Therapeutics, Inc.                                | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |    477958 | NS      | $23343468.72  | 0.44%             |  |  |  | No            |                  1 | On Loan: No      |
| Ultragenyx Pharmaceutical, Inc.                | Ultragenyx Pharmaceutical, Inc.                       | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |    547551 | NS      | $19908954.36  | 0.38%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvalent, Inc.                                 | Nuvalent, Inc., Class A                               | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    275626 | NS      | $21030263.80  | 0.40%             |  |  |  | No            |                  1 | On Loan: —       |
| Astria Therapeutics, Inc.                      | Astria Therapeutics, Inc.                             | CUSIP: 04635X102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    277041 | NS      | $1484939.76   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Codexis, Inc.                                  | Codexis, Inc.                                         | CUSIP: 192005106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    501522 | NS      | $1223713.68   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Natera, Inc.                                   | Natera, Inc.                                          | CUSIP: 632307104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    801042 | NS      | $135328035.48 | 2.56%             |  |  |  | No            |                  1 | On Loan: No      |
| ArriVent Biopharma, Inc.                       | ArriVent Biopharma, Inc.                              | CUSIP: 04272N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    120337 | NS      | $2619736.49   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| CareDx, Inc.                                   | CareDx, Inc.                                          | CUSIP: 14167L103<br>LEI: 549300NQOFKL9NON0U06 | Long             | EC               | CORP              | US        |    322186 | NS      | $6295514.44   | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| UroGen Pharma Ltd.                             | UroGen Pharma Ltd.                                    | CUSIP: N/A<br>LEI: 549300C0YCX7CG2G5D50       | Long             | EC               | CORP              | IL        |    240971 | NS      | $3301302.70   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Mirum Pharmaceuticals, Inc.                    | Mirum Pharmaceuticals, Inc.                           | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |    247464 | NS      | $12593442.96  | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Kyverna Therapeutics, Inc.                     | Kyverna Therapeutics, Inc.                            | CUSIP: 501976104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    130488 | NS      | $400598.16    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| OPKO Health, Inc.                              | OPKO Health, Inc.                                     | CUSIP: 68375N103<br>LEI: 529900A4S2D4OGOJLL02 | Long             | EC               | CORP              | US        |   2170172 | NS      | $2864627.04   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Pacific Biosciences of California, Inc.        | Pacific Biosciences of California, Inc.               | CUSIP: 69404D108<br>LEI: 529900F1BWRE1M0KZN89 | Long             | EC               | CORP              | US        |   1636798 | NS      | $2029629.52   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| MaxCyte, Inc.                                  | MaxCyte, Inc.                                         | CUSIP: 57777K106<br>LEI: 54930053YHXULRFCU991 | Long             | EC               | CORP              | US        |    606809 | NS      | $1322843.62   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Xencor, Inc.                                   | Xencor, Inc.                                          | CUSIP: 98401F105<br>LEI: 549300V5IF65437JKG30 | Long             | EC               | CORP              | US        |    414379 | NS      | $3257018.94   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Sarepta Therapeutics, Inc.                     | Sarepta Therapeutics, Inc.                            | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |    578538 | NS      | $9892999.80   | 0.19%             |  |  |  | No            |                  1 | On Loan: —       |
| Arcutis Biotherapeutics, Inc.                  | Arcutis Biotherapeutics, Inc.                         | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    649529 | NS      | $9106396.58   | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Summit Therapeutics, Inc.                      | Summit Therapeutics, Inc.                             | CUSIP: 86627T108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    690737 | NS      | $14698883.36  | 0.28%             |  |  |  | No            |                  1 | On Loan: —       |
| Corvus Pharmaceuticals, Inc.                   | Corvus Pharmaceuticals, Inc.                          | CUSIP: 221015100<br>LEI: 549300I3AVJ8F75NCX65 | Long             | EC               | CORP              | US        |    330558 | NS      | $1322232.00   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Nuvation Bio, Inc.                             | Nuvation Bio, Inc., Class A                           | CUSIP: 67080N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1404902 | NS      | $2739558.90   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Atea Pharmaceuticals, Inc.                     | Atea Pharmaceuticals, Inc.                            | CUSIP: 04683R106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    436459 | NS      | $1571252.40   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| CG oncology, Inc.                              | CG oncology, Inc.                                     | CUSIP: 156944100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    277242 | NS      | $7208292.00   | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| Iovance Biotherapeutics, Inc.                  | Iovance Biotherapeutics, Inc.                         | CUSIP: 462260100<br>LEI: 2549002L8WT2ACU5Q878 | Long             | EC               | CORP              | US        |   1682683 | NS      | $2894214.76   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Biomea Fusion, Inc.                            | Biomea Fusion, Inc.                                   | CUSIP: 09077A106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    207107 | NS      | $372792.60    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Annexon, Inc.                                  | Annexon, Inc.                                         | CUSIP: 03589W102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    591915 | NS      | $1420596.00   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Cargo Therapeutics, Inc.                       | Cargo Therapeutics, Inc.                              | CUSIP: 14179K101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    201237 | NS      | $829096.44    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Syndax Pharmaceuticals, Inc.                   | Syndax Pharmaceuticals, Inc.                          | CUSIP: 87164F105<br>LEI: 529900OF94TRHKZVBS87 | Long             | EC               | CORP              | US        |    510964 | NS      | $4785177.86   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals, Inc.                  | Alnylam Pharmaceuticals, Inc.                         | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |    772459 | NS      | $251891155.31 | 4.77%             |  |  |  | No            |                  1 | On Loan: —       |
| Inhibrx Biosciences, Inc.                      | Inhibrx Biosciences, Inc.                             | CUSIP: 45720N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     58995 | NS      | $841858.65    | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Vaxcyte, Inc.                                  | Vaxcyte, Inc.                                         | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |    774907 | NS      | $25192226.57  | 0.48%             |  |  |  | No            |                  1 | On Loan: —       |
| Keros Therapeutics, Inc.                       | Keros Therapeutics, Inc.                              | CUSIP: 492327101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    207613 | NS      | $2771633.55   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Ascendis Pharma A/S                            | Ascendis Pharma A/S                                   | CUSIP: 04351P101<br>LEI: 549300B66JN3W3J8GH73 | Long             | EC               | CORP              | DK        |    237140 | NS      | $40930364.00  | 0.78%             |  |  |  | No            |                  1 | On Loan: —       |
| Novavax, Inc.                                  | Novavax, Inc.                                         | CUSIP: 670002401<br>LEI: 529900J4GJHPEPQ23205 | Long             | EC               | CORP              | US        |    914514 | NS      | $5761438.20   | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| Beam Therapeutics, Inc.                        | Beam Therapeutics, Inc.                               | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    555257 | NS      | $9444921.57   | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Oruka Therapeutics, Inc.                       | Oruka Therapeutics, Inc.                              | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |    191478 | NS      | $2146468.38   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Taysha Gene Therapies, Inc.                    | Taysha Gene Therapies, Inc.                           | CUSIP: 877619106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1092201 | NS      | $2522984.31   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Agios Pharmaceuticals, Inc.                    | Agios Pharmaceuticals, Inc.                           | CUSIP: 00847X104<br>LEI: 529900ONJHY8EOGYT555 | Long             | EC               | CORP              | US        |    343500 | NS      | $11424810.00  | 0.22%             |  |  |  | No            |                  1 | On Loan: —       |
| Ginkgo Bioworks Holdings, Inc.                 | Ginkgo Bioworks Holdings, Inc.                        | CUSIP: 37611X209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    231794 | NS      | $2607682.50   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Verona Pharma plc                              | Verona Pharma plc                                     | CUSIP: 925050106<br>LEI: 213800EVI6O6J3TIAL06 | Long             | EC               | CORP              | GB        |    300635 | NS      | $28434058.30  | 0.54%             |  |  |  | No            |                  1 | On Loan: —       |
| Axsome Therapeutics, Inc.                      | Axsome Therapeutics, Inc.                             | CUSIP: 05464T104<br>LEI: 549300EXGR0XLRJEIB95 | Long             | EC               | CORP              | US        |    250621 | NS      | $26162326.19  | 0.50%             |  |  |  | No            |                  1 | On Loan: —       |
| Humacyte, Inc.                                 | Humacyte, Inc.                                        | CUSIP: 44486Q103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    779109 | NS      | $1628337.81   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| ADMA Biologics, Inc.                           | ADMA Biologics, Inc.                                  | CUSIP: 000899104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1427517 | NS      | $25995084.57  | 0.49%             |  |  |  | No            |                  1 | On Loan: —       |
| Alvotech SA                                    | Alvotech SA                                           | CUSIP: N/A<br>LEI: 222100DCZBOWV5DZ8372       | Long             | EC               | CORP              | LU        |    675119 | NS      | $6157085.28   | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Newamsterdam Pharma Co. NV                     | Newamsterdam Pharma Co. NV                            | CUSIP: N/A<br>LEI: 984500B6549TF6E14D36       | Long             | EC               | CORP              | NL        |    385830 | NS      | $6987381.30   | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Crinetics Pharmaceuticals, Inc.                | Crinetics Pharmaceuticals, Inc.                       | CUSIP: 22663K107<br>LEI: 549300Q1CNFXK5P31D28 | Long             | EC               | CORP              | US        |    537648 | NS      | $15462756.48  | 0.29%             |  |  |  | No            |                  1 | On Loan: —       |
| Alector, Inc.                                  | Alector, Inc.                                         | CUSIP: 014442107<br>LEI: 549300Z8RQOIY1JMHC25 | Long             | EC               | CORP              | US        |    465443 | NS      | $651620.20    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| AnaptysBio, Inc.                               | AnaptysBio, Inc.                                      | CUSIP: 032724106<br>LEI: 529900HH4WQT03IG1A12 | Long             | EC               | CORP              | US        |    164031 | NS      | $3641488.20   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Arcus Biosciences, Inc.                        | Arcus Biosciences, Inc.                               | CUSIP: 03969F109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    395861 | NS      | $3222308.54   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Arvinas, Inc.                                  | Arvinas, Inc.                                         | CUSIP: 04335A105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    395127 | NS      | $2908134.72   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Geron Corp.                                    | Geron Corp.                                           | CUSIP: 374163103<br>LEI: 549300T282D7Z2YESL90 | Long             | EC               | CORP              | US        |   3738579 | NS      | $5271396.39   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Vanda Pharmaceuticals, Inc.                    | Vanda Pharmaceuticals, Inc.                           | CUSIP: 921659108<br>LEI: 529900AY8VOOQBKJ0O70 | Long             | EC               | CORP              | US        |    333246 | NS      | $1572921.12   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Autolus Therapeutics plc                       | Autolus Therapeutics plc                              | CUSIP: 05280R100<br>LEI: 549300C0KZP8EYROLL02 | Long             | EC               | CORP              | GB        |    941889 | NS      | $2147506.92   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| ACADIA Pharmaceuticals, Inc.                   | ACADIA Pharmaceuticals, Inc.                          | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |   1028863 | NS      | $22192574.91  | 0.42%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals, Inc.                   | Vertex Pharmaceuticals, Inc.                          | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |    916868 | NS      | $408189633.60 | 7.73%             |  |  |  | No            |                  1 | On Loan: —       |
| Cogent Biosciences, Inc.                       | Cogent Biosciences, Inc.                              | CUSIP: 19240Q201<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    582578 | NS      | $4182910.04   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| ARS Pharmaceuticals, Inc.                      | ARS Pharmaceuticals, Inc.                             | CUSIP: 82835W108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    339356 | NS      | $5921762.20   | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| REGENXBIO, Inc.                                | REGENXBIO, Inc.                                       | CUSIP: 75901B107<br>LEI: 549300EOES47LATSET33 | Long             | EC               | CORP              | US        |    282045 | NS      | $2315589.45   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| BioCryst Pharmaceuticals, Inc.                 | BioCryst Pharmaceuticals, Inc.                        | CUSIP: 09058V103<br>LEI: 549300Z0INP1Z5NP6J59 | Long             | EC               | CORP              | US        |   1242129 | NS      | $11129475.84  | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| LENZ Therapeutics, Inc.                        | LENZ Therapeutics, Inc.                               | CUSIP: 52635N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    146101 | NS      | $4282220.31   | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Tevogen Bio Holdings, Inc.                     | Tevogen Bio Holdings, Inc.                            | CUSIP: 88165K101<br>LEI: 549300AC21G4NBK9D322 | Long             | EC               | CORP              | US        |    177759 | NS      | $222198.75    | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| Rapport Therapeutics, Inc.                     | Rapport Therapeutics, Inc.                            | CUSIP: 75383L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    108463 | NS      | $1233224.31   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Climb Bio, Inc.                                | Climb Bio, Inc.                                       | CUSIP: 28658R106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    371003 | NS      | $460043.72    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Legend Biotech Corp.                           | Legend Biotech Corp.                                  | CUSIP: 52490G102<br>LEI: 254900EIUFZTW136H859 | Long             | EC               | CORP              | KY        |    709374 | NS      | $25175683.26  | 0.48%             |  |  |  | No            |                  1 | On Loan: —       |
| Arrowhead Pharmaceuticals, Inc.                | Arrowhead Pharmaceuticals, Inc.                       | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |    713849 | NS      | $11278814.20  | 0.21%             |  |  |  | No            |                  1 | On Loan: —       |
| Stevanato Group SpA                            | Stevanato Group SpA                                   | CUSIP: N/A<br>LEI: 81560033F7E1CD477507       | Long             | EC               | CORP              | IT        |    307338 | NS      | $7508267.34   | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| Avidity Biosciences, Inc.                      | Avidity Biosciences, Inc.                             | CUSIP: 05370A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    680521 | NS      | $19326796.40  | 0.37%             |  |  |  | No            |                  1 | On Loan: —       |
| Tourmaline Bio, Inc.                           | Tourmaline Bio, Inc.                                  | CUSIP: 89157D105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    101428 | NS      | $1621833.72   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Zymeworks, Inc.                                | Zymeworks, Inc.                                       | CUSIP: 98985Y108<br>LEI: 894500AHOYAGYLYZJL67 | Long             | EC               | CORP              | US        |    419686 | NS      | $5267059.30   | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| Inozyme Pharma, Inc.                           | Inozyme Pharma, Inc.                                  | CUSIP: 45790W108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    270993 | NS      | $1083972.00   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Contra Chinook Therape                         | Contra Chinook Therape, CVR                           | CUSIP: 169CVR016<br>LEI: N/A                  | Long             |  | CORP              | US        |    320962 | NS      | $51353.92     | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Artiva Biotherapeutics, Inc.                   | Artiva Biotherapeutics, Inc.                          | CUSIP: 04317A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     69109 | NS      | $104354.59    | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| Immunovant, Inc.                               | Immunovant, Inc.                                      | CUSIP: 45258J102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    424813 | NS      | $6797008.00   | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| GRAIL, Inc.                                    | GRAIL, Inc.                                           | CUSIP: 384747101<br>LEI: 2549009XSNESW3VE8024 | Long             | EC               | CORP              | US        |    184106 | NS      | $9466730.52   | 0.18%             |  |  |  | No            |                  1 | On Loan: —       |
| Silence Therapeutics plc                       | Silence Therapeutics plc                              | CUSIP: 82686Q101<br>LEI: 213800SSURRJBX85SQ91 | Long             | EC               | CORP              | GB        |    147383 | NS      | $854821.40    | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Vir Biotechnology, Inc.                        | Vir Biotechnology, Inc.                               | CUSIP: 92764N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    552300 | NS      | $2783592.00   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Prime Medicine, Inc.                           | Prime Medicine, Inc.                                  | CUSIP: 74168J101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    322262 | NS      | $795987.14    | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Third Harmonic Bio, Inc.                       | Third Harmonic Bio, Inc.                              | CUSIP: 88427A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    138130 | NS      | $750045.90    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Akero Therapeutics, Inc.                       | Akero Therapeutics, Inc.                              | CUSIP: 00973Y108<br>LEI: 549300SI3KG74LBE2955 | Long             | EC               | CORP              | US        |    444283 | NS      | $23706940.88  | 0.45%             |  |  |  | No            |                  1 | On Loan: —       |
| Maravai LifeSciences Holdings, Inc.            | Maravai LifeSciences Holdings, Inc., Class A          | CUSIP: 56600D107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    663264 | NS      | $1598466.24   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Intellia Therapeutics, Inc.                    | Intellia Therapeutics, Inc.                           | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |    603944 | NS      | $5664994.72   | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| Mersana Therapeutics, Inc.                     | Mersana Therapeutics, Inc.                            | CUSIP: 59045L106<br>LEI: 529900VWD5VDZ7PVOS22 | Long             | EC               | CORP              | US        |    627252 | NS      | $185666.59    | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| Mesoblast Ltd.                                 | Mesoblast Ltd.                                        | CUSIP: 590717401<br>LEI: 529900J5ALF3JG921927 | Long             | EC               | CORP              | AU        |    500796 | NS      | $5453668.44   | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| Precigen, Inc.                                 | Precigen, Inc.                                        | CUSIP: 74017N105<br>LEI: 549300XCWNQU35K64G19 | Long             | EC               | CORP              | US        |   1003294 | NS      | $1424677.48   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Aurinia Pharmaceuticals, Inc.                  | Aurinia Pharmaceuticals, Inc.                         | CUSIP: 05156V102<br>LEI: 5299008YP2BW4570ML28 | Long             | EC               | CORP              | CA        |    742382 | NS      | $6287975.54   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Scholar Rock Holding Corp.                     | Scholar Rock Holding Corp.                            | CUSIP: 80706P103<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |    450607 | NS      | $15960499.94  | 0.30%             |  |  |  | No            |                  1 | On Loan: —       |
| Altimmune, Inc.                                | Altimmune, Inc.                                       | CUSIP: 02155H200<br>LEI: 549300EOYCQ8SW3NVE64 | Long             | EC               | CORP              | US        |    497309 | NS      | $1924585.83   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| IQVIA Holdings, Inc.                           | IQVIA Holdings, Inc.                                  | CUSIP: 46266C105<br>LEI: 549300W3R20NM4KQPH86 | Long             | EC               | CORP              | US        |   1062566 | NS      | $167449775.94 | 3.17%             |  |  |  | No            |                  1 | On Loan: —       |
| Rigel Pharmaceuticals, Inc.                    | Rigel Pharmaceuticals, Inc.                           | CUSIP: 766559702<br>LEI: 529900KPTNUS5J8K9K66 | Long             | EC               | CORP              | US        |    107650 | NS      | $2016284.50   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Protagonist Therapeutics, Inc.                 | Protagonist Therapeutics, Inc.                        | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    361275 | NS      | $19967669.25  | 0.38%             |  |  |  | No            |                  1 | On Loan: —       |
| ImmunityBio, Inc.                              | ImmunityBio, Inc.                                     | CUSIP: 45256X103<br>LEI: 529900J9XLBR4HFL4B83 | Long             | EC               | CORP              | US        |    568913 | NS      | $1501930.32   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Travere Therapeutics, Inc.                     | Travere Therapeutics, Inc.                            | CUSIP: 89422G107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    542135 | NS      | $8023598.00   | 0.15%             |  |  |  | No            |                  1 | On Loan: —       |
| TScan Therapeutics, Inc.                       | TScan Therapeutics, Inc.                              | CUSIP: 89854M101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    275348 | NS      | $399254.60    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Bridgebio Pharma, Inc.                         | Bridgebio Pharma, Inc.                                | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |    996006 | NS      | $43007539.08  | 0.81%             |  |  |  | No            |                  1 | On Loan: —       |
| BeOne Medicines Ltd.                           | BeOne Medicines Ltd.                                  | CUSIP: 07725L102<br>LEI: 549300JFUK6FRD5MH739 | Long             | EC               | CORP              | CH        |    345647 | NS      | $83670769.29  | 1.59%             |  |  |  | No            |                  1 | On Loan: —       |
| Cartesian Therapeutics, Inc.                   | Cartesian Therapeutics, Inc.                          | CUSIP: 816212112<br>LEI: 529900NMN0LACZOL7C43 | Long             |  | CORP              | US        |      6098 | NS      | $1463.52      | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Adaptive Biotechnologies Corp.                 | Adaptive Biotechnologies Corp.                        | CUSIP: 00650F109<br>LEI: 549300ZTF7OT1FW66Q96 | Long             | EC               | CORP              | US        |    897850 | NS      | $10459952.50  | 0.20%             |  |  |  | No            |                  1 | On Loan: —       |
| Rocket Pharmaceuticals, Inc.                   | Rocket Pharmaceuticals, Inc.                          | CUSIP: 77313F106<br>LEI: 549300R7VV82YUIN4Y93 | Long             | EC               | CORP              | US        |    618170 | NS      | $1514516.50   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Larimar Therapeutics, Inc.                     | Larimar Therapeutics, Inc.                            | CUSIP: 517125100<br>LEI: 529900NCBZHTTJV6HX73 | Long             | EC               | CORP              | US        |    233089 | NS      | $673627.21    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Arcellx, Inc.                                  | Arcellx, Inc.                                         | CUSIP: 03940C100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    244714 | NS      | $16114416.90  | 0.31%             |  |  |  | No            |                  1 | On Loan: —       |
| Amgen, Inc.                                    | Amgen, Inc.                                           | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |   1406389 | NS      | $392677872.69 | 7.44%             |  |  |  | No            |                  1 | On Loan: No      |
| C4 Therapeutics, Inc.                          | C4 Therapeutics, Inc.                                 | CUSIP: 12529R107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    340951 | NS      | $487559.93    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Halozyme Therapeutics, Inc.                    | Halozyme Therapeutics, Inc.                           | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |    755038 | NS      | $39277076.76  | 0.74%             |  |  |  | No            |                  1 | On Loan: —       |
| CorMedix, Inc.                                 | CorMedix, Inc.                                        | CUSIP: 21900C308<br>LEI: 5299006YIA3L0MBW8358 | Long             | EC               | CORP              | US        |    408689 | NS      | $5035048.48   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                            | XAV Health Care Index                                 | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |        32 | NC      | $-55472.64    | -0.00%            |  |  |  | No            |                  1 | On Loan: No      |
| Evotec SE                                      | Evotec SE                                             | CUSIP: 30050E105<br>LEI: 529900F9KI6OYITO9B12 | Long             | EC               | CORP              | DE        |   1321318 | NS      | $5549535.60   | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| Spyre Therapeutics, Inc.                       | Spyre Therapeutics, Inc.                              | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |    319486 | NS      | $4782705.42   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| IGM Biosciences, Inc.                          | IGM Biosciences, Inc.                                 | CUSIP: 449585108<br>LEI: 5493008XCQES2N0VY969 | Long             | EC               | CORP              | US        |     97300 | NS      | $108976.00    | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| KalVista Pharmaceuticals, Inc.                 | KalVista Pharmaceuticals, Inc.                        | CUSIP: 483497103<br>LEI: 529900Q7IDA3WUGRZA51 | Long             | EC               | CORP              | US        |    238539 | NS      | $2696683.40   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Krystal Biotech, Inc.                          | Krystal Biotech, Inc.                                 | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |    153738 | NS      | $21132825.48  | 0.40%             |  |  |  | No            |                  1 | On Loan: —       |
| Lyell Immunopharma, Inc.                       | Lyell Immunopharma, Inc.                              | CUSIP: 55083R203<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     36617 | NS      | $323694.28    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| BlackRock Funds III                            | BlackRock Cash Funds: Treasury, SL Agency Shares      | CUSIP: 066922477<br>LEI: 5493005PQV5UQG4OSI49 | Long             | STIV             | RF                | US        |   8381076 | NS      | $8381076.37   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Monte Rosa Therapeutics, Inc.                  | Monte Rosa Therapeutics, Inc.                         | CUSIP: 61225M102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    284951 | NS      | $1285129.01   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Personalis, Inc.                               | Personalis, Inc.                                      | CUSIP: 71535D106<br>LEI: 549300EZ2NYFK7H0US48 | Long             | EC               | CORP              | US        |    326808 | NS      | $2143860.48   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Relay Therapeutics, Inc.                       | Relay Therapeutics, Inc.                              | CUSIP: 75943R102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    800915 | NS      | $2771165.90   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Regeneron Pharmaceuticals, Inc.                | Regeneron Pharmaceuticals, Inc.                       | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |    644752 | NS      | $338494800.00 | 6.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Cartesian Therapeutics, Inc.                   | Cartesian Therapeutics, Inc.                          | CUSIP: 816212302<br>LEI: 529900NMN0LACZOL7C43 | Long             | EC               | CORP              | US        |     51273 | NS      | $532726.47    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Tectonic Therapeutic, Inc.                     | Tectonic Therapeutic, Inc.                            | CUSIP: 878972108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     66229 | NS      | $1315970.23   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| CRISPR Therapeutics AG                         | CRISPR Therapeutics AG                                | CUSIP: N/A<br>LEI: 506700O6IRRIQLT3W370       | Long             | EC               | CORP              | CH        |    513004 | NS      | $24952514.56  | 0.47%             |  |  |  | No            |                  1 | On Loan: —       |
| Pyxis Oncology, Inc.                           | Pyxis Oncology, Inc.                                  | CUSIP: 747324101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    285340 | NS      | $313874.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Gilead Sciences, Inc.                          | Gilead Sciences, Inc.                                 | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |   3681666 | NS      | $408186309.42 | 7.73%             |  |  |  | No            |                  1 | On Loan: No      |
| Sana Biotechnology, Inc.                       | Sana Biotechnology, Inc.                              | CUSIP: 799566104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    777225 | NS      | $2121824.25   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| iTeos Therapeutics, Inc.                       | iTeos Therapeutics, Inc.                              | CUSIP: 46565G104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    223045 | NS      | $2223758.65   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| PepGen, Inc.                                   | PepGen, Inc.                                          | CUSIP: 713317105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    179694 | NS      | $199460.34    | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| Apellis Pharmaceuticals, Inc.                  | Apellis Pharmaceuticals, Inc.                         | CUSIP: 03753U106<br>LEI: 254900HS0ZFRXXSB9D42 | Long             | EC               | CORP              | US        |    641831 | NS      | $11110094.61  | 0.21%             |  |  |  | No            |                  1 | On Loan: —       |
| Incyte Corp.                                   | Incyte Corp.                                          | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |   1181809 | NS      | $80481192.90  | 1.52%             |  |  |  | No            |                  1 | On Loan: No      |
| Structure Therapeutics, Inc.                   | Structure Therapeutics, Inc.                          | CUSIP: 86366E106<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |    214351 | NS      | $4445639.74   | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Y-mAbs Therapeutics, Inc.                      | Y-mAbs Therapeutics, Inc.                             | CUSIP: 984241109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    206816 | NS      | $932740.16    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Grifols SA                                     | Grifols SA                                            | CUSIP: 398438408<br>LEI: 959800HSSNXWRKBK4N60 | Long             | EC               | CORP              | ES        |   1022134 | NS      | $9240091.36   | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Denali Therapeutics, Inc.                      | Denali Therapeutics, Inc.                             | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |    779288 | NS      | $10902239.12  | 0.21%             |  |  |  | No            |                  1 | On Loan: —       |
| AC Immune SA                                   | AC Immune SA                                          | CUSIP: N/A<br>LEI: 967600VLQ0ZC2HSOG765       | Long             | EC               | CORP              | CH        |    361084 | NS      | $733000.52    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Biohaven Ltd.                                  | Biohaven Ltd.                                         | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | VG        |    552465 | NS      | $7795281.15   | 0.15%             |  |  |  | No            |                  1 | On Loan: —       |
| AbCellera Biologics, Inc.                      | AbCellera Biologics, Inc.                             | CUSIP: 00288U106<br>LEI: 9845000861BC95FF9F73 | Long             | EC               | CORP              | CA        |   1387558 | NS      | $4759323.94   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Immunocore Holdings plc                        | Immunocore Holdings plc                               | CUSIP: 45258D105<br>LEI: 213800IUE3DFS84BVN18 | Long             | EC               | CORP              | GB        |    190752 | NS      | $5985797.76   | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| CureVac NV                                     | CureVac NV                                            | CUSIP: N/A<br>LEI: 724500BUT8GAG9LMYN56       | Long             | EC               | CORP              | NL        |    582476 | NS      | $3162844.68   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| OnKure Therapeutics, Inc.                      | OnKure Therapeutics, Inc.                             | CUSIP: 68277Q105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     53779 | NS      | $128531.81    | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| BioNTech SE                                    | BioNTech SE                                           | CUSIP: 09075V102<br>LEI: 894500UZJ5LG1F8J1U58 | Long             | EC               | CORP              | DE        |    927706 | NS      | $98772857.82  | 1.87%             |  |  |  | No            |                  1 | On Loan: —       |
| Zevra Therapeutics, Inc.                       | Zevra Therapeutics, Inc.                              | CUSIP: 488445206<br>LEI: 254900CU6T74V18Y1W18 | Long             | EC               | CORP              | US        |    335061 | NS      | $2951887.41   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Foghorn Therapeutics, Inc.                     | Foghorn Therapeutics, Inc.                            | CUSIP: 344174107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    167692 | NS      | $788152.40    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Arbutus Biopharma Corp.                        | Arbutus Biopharma Corp.                               | CUSIP: 03879J100<br>LEI: 25490064CESONAUIAS23 | Long             | EC               | CORP              | CA        |    921091 | NS      | $2846171.19   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Vericel Corp.                                  | Vericel Corp.                                         | CUSIP: 92346J108<br>LEI: 54930076YM3PLTDR4B91 | Long             | EC               | CORP              | US        |    308495 | NS      | $13126462.25  | 0.25%             |  |  |  | No            |                  1 | On Loan: —       |
| Trevi Therapeutics, Inc.                       | Trevi Therapeutics, Inc.                              | CUSIP: 89532M101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    369736 | NS      | $2022455.92   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Nkarta, Inc.                                   | Nkarta, Inc.                                          | CUSIP: 65487U108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    323234 | NS      | $536568.44    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Voyager Therapeutics, Inc.                     | Voyager Therapeutics, Inc.                            | CUSIP: 92915B106<br>LEI: 54930082S4XVR0ZWCC74 | Long             | EC               | CORP              | US        |    281380 | NS      | $875091.80    | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Acrivon Therapeutics, Inc.                     | Acrivon Therapeutics, Inc.                            | CUSIP: 004890109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    132008 | NS      | $157089.52    | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| Erasca, Inc.                                   | Erasca, Inc.                                          | CUSIP: 29479A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    969691 | NS      | $1231507.57   | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Emergent BioSolutions, Inc.                    | Emergent BioSolutions, Inc.                           | CUSIP: 29089Q105<br>LEI: 549300YW6TUOX8BE5103 | Long             | EC               | CORP              | US        |    324450 | NS      | $2069991.00   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Immutep Ltd.                                   | Immutep Ltd.                                          | CUSIP: 45257L108<br>LEI: 529900OL6C5CY5P8BH38 | Long             | EC               | CORP              | AU        |    602104 | NS      | $987450.56    | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Compass Pathways plc                           | Compass Pathways plc                                  | CUSIP: 20451W101<br>LEI: 213800N7CUZIC6QSTZ31 | Long             | EC               | CORP              | GB        |    332413 | NS      | $930756.40    | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Tyra Biosciences, Inc.                         | Tyra Biosciences, Inc.                                | CUSIP: 90240B106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    199507 | NS      | $1909281.99   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Moderna, Inc.                                  | Moderna, Inc.                                         | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |   2122005 | NS      | $58546117.95  | 1.11%             |  |  |  | No            |                  1 | On Loan: —       |
| Dynavax Technologies Corp.                     | Dynavax Technologies Corp.                            | CUSIP: 268158201<br>LEI: 549300T5URIXWDILX594 | Long             | EC               | CORP              | US        |    712632 | NS      | $7069309.44   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Alkermes plc                                   | Alkermes plc                                          | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | IE        |    999195 | NS      | $28586968.95  | 0.54%             |  |  |  | No            |                  1 | On Loan: No      |
| Veracyte, Inc.                                 | Veracyte, Inc.                                        | CUSIP: 92337F107<br>LEI: 529900ESWZRHXOW27Z37 | Long             | EC               | CORP              | US        |    478316 | NS      | $12928881.48  | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Anavex Life Sciences Corp.                     | Anavex Life Sciences Corp.                            | CUSIP: 032797300<br>LEI: 549300K1I5L8COCQ8W36 | Long             | EC               | CORP              | US        |    511493 | NS      | $4715965.46   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Akouos, Inc.                                   | Akouos, Inc., CVR                                     | CUSIP: 009CVR036<br>LEI: N/A                  | Long             |  | CORP              | US        |    157087 | NS      | $1.57         | 0.00%             |  |  |  | No            |                  3 | On Loan: —       |
| Terns Pharmaceuticals, Inc.                    | Terns Pharmaceuticals, Inc.                           | CUSIP: 880881107<br>LEI: 254900S1ZDQMF4MYP709 | Long             | EC               | CORP              | US        |    411652 | NS      | $1535461.96   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| OmniAb Operations, Inc.                        | OmniAb, Inc.,                                         | CUSIP: 68218J202<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     46839 | NS      | $0.47         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Neumora Therapeutics, Inc.                     | Neumora Therapeutics, Inc.                            | CUSIP: 640979100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    413575 | NS      | $303274.55    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Verve Therapeutics, Inc.                       | Verve Therapeutics, Inc.                              | CUSIP: 92539P101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    407416 | NS      | $4575281.68   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |

### Signature

**Date Signed:** 2025-06-30

**Name of Applicant:** iShares Trust

**Signature:** Chuck Pulsfort

**Name of Signer:** Chuck Pulsfort

**Title:** Assistant Treasurer