# EDGAR Filing Document

**Accession Number:** 0001835597
**File Stem:** 0001193125-26-091579
**Filing Date:** 2026-3
**Character Count:** 22664
**Document Hash:** 5bafee50b1209e6205d24fc0abac50b2
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-26-091579.hdr.sgml**: 20260304

**ACCESSION NUMBER**: 0001193125-26-091579

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 14

**FILED AS OF DATE**: 20260304

**DATE AS OF CHANGE**: 20260304

**EFFECTIVENESS DATE**: 20260304

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** PepGen Inc.
- **CENTRAL INDEX KEY:** 0001835597
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-294012
- **FILM NUMBER:** 26721616

**BUSINESS ADDRESS:**
- **STREET 1:** 1 MARINA PARK DRIVE, SUITE 900
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02210
- **BUSINESS PHONE:** 703-456-8000

**MAIL ADDRESS:**
- **STREET 1:** 1 MARINA PARK DRIVE, SUITE 900
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02210

**As filed with the Securities and Exchange Commission on March 4, 2026** 

**Registration No. 333-**

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**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**Washington, D.C. 20549** 

------

**FORM S-8** 

**REGISTRATION STATEMENT** 

***Under*** 

***The Securities Act of 1933*** 

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**PEPGEN INC.** 

**(Exact name of registrant as specified in its charter)** 

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---

| | |
|:---|:---|
| **Delaware** | **85-3819886** |
| **(State or other jurisdiction of**<br>**incorporation or organization)** | **(I.R.S. Employer**<br>**Identification No.)** |

---

**321 Harrison Avenue**

**Boston, Massachusetts 02118**

**(781) 797-0979**

**(Address, including zip code and telephone number, including area code, of Registrant's principal executive offices)** 

**PepGen Inc. 2022 Stock Option and Incentive Plan**

**PepGen Inc. 2022 Employee Stock Purchase Plan** 

**(Full title of the plan)** 

**James McArthur, Ph.D.**

**President and Chief Executive Officer**

**PepGen Inc.**

**321 Harrison Avenue**

**Boston, Massachusetts 02118**

**(781) 797-0979** 

**(Name, address, including zip code, and telephone number, including area code, of agent for service)** 

***Copies to:*** 

**Edwin O'Connor, Esq.**

**Finnbarr Murphy, Esq.**

**Goodwin Procter LLP**

**100 Northern Avenue**

**Boston, Massachusetts 02210**

**(617) 570-1000**

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Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

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| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☐ | Accelerated filer | ☐ |
| Non-accelerated filer | ☒ | Smaller reporting company | ☒ |
|  |  | Emerging growth company | ☒ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

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**REGISTRATION OF ADDITIONAL SECURITIES PURSUANT TO GENERAL INSTRUCTIONS E**

This Registration Statement on Form S-8 (this "Registration Statement") is being filed by PepGen Inc. (the "registrant") with the Securities and Exchange Commission (the "Commission") to register 3,443,747 additional shares of its common stock, par value $0.0001 per share (the "Common Stock"), reserved for issuance under the PepGen Inc. 2022 Stock Option and Incentive Plan (the "2022 Plan") and 678,000 additional shares of its Common Stock, reserved for issuance under the 2022 Employee Stock Purchase Plan (the "2022 ESPP"), pursuant to the "evergreen" provisions of the 2022 Plan and the 2022 ESPP.

The number of shares of Common Stock reserved and available for issuance under the 2022 Plan is subject to an automatic annual increase on each January 1, in an amount equal to the lesser of: (i) 5% of the outstanding shares on the immediately preceding December 31, or (ii) such lesser amount as determined by the Administrator.

The number of shares of Common Stock reserved and available for issuance under the 2022 ESPP is subject to an automatic annual increase by the lesser of (i) one percent (1%) of the number of shares of Common Stock issued and outstanding on the immediately preceding December 31st, (ii) 678,000 shares of Common Stock or (iii) such number of shares of Common Stock as determined by the Administrator.

The additional shares are of the same class as other securities relating to the 2022 Plan and the 2022 ESPP for which the registrant's registration statements filed on Form S-8 with the Commission on May 10, 2022 ([<u>File No. 333-264822</u>](https://www.sec.gov/Archives/edgar/data/1835597/000119312522146267/d321093ds8.htm)), March 23, 2023 ([<u>File No. 333-270790</u>](https://www.sec.gov/Archives/edgar/data/1835597/000095017023009522/pepg_s-8_2023.htm)), March 6, 2024 ([<u>File No. 333-277708</u>](https://www.sec.gov/Archives/edgar/data/1835597/000095017024027262/pepg_s-8_2024.htm)) and February 24, 2025 ([<u>File No. 333-285166</u>](https://www.sec.gov/Archives/edgar/data/1835597/000095017025025627/pepg_s-8_2025.htm)) are effective.

Pursuant to General Instruction E of Form S-8 regarding Registration of Additional Securities, the contents of the Registration Statements on Form S-8 filed with the Commission on May 10, 2022 ([<u>File No. 333-264822</u>](https://www.sec.gov/Archives/edgar/data/1835597/000119312522146267/d321093ds8.htm)), March 23, 2023 ([<u>File No. 333-270790</u>](https://www.sec.gov/Archives/edgar/data/1835597/000095017023009522/pepg_s-8_2023.htm)), March 6, 2024 ([<u>File No. 333-277708</u>](https://www.sec.gov/Archives/edgar/data/1835597/000095017024027262/pepg_s-8_2024.htm)) and February 24, 2025 ([<u>File No. 333-285166</u>](https://www.sec.gov/Archives/edgar/data/1835597/000095017025025627/pepg_s-8_2025.htm)) are hereby incorporated by reference in this Registration Statement, except to the extent supplemented, amended or superseded by the information set forth herein.

**Part I**

**INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS**

**Item 1. Plan Information.**

The documents containing the information specified in this Item 1 will be sent or given to participants as specified by Rule 428(b)(1) under the Securities Act. In accordance with the rules and regulations of the Commission and the instructions to Form S-8, such documents are not being filed with the Commission either as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424 under the Securities Act.

**Item 2. Registrant Information and Employee Plan Annual Information.**

The documents containing the information specified in this Item 2 will be sent or given to participants as specified by Rule 428(b)(1) under the Securities Act. In accordance with the rules and regulations of the Commission and the instructions to Form S-8, such documents are not being filed with the Commission either as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424 under the Securities Act.

------

**Part II**

**Item 8. Exhibits.** 

**EXHIBIT INDEX** 

---

| | |
|:---|:---|
| **Exhibit<br>No.** | **Description** |
| 4.1 | [<u>Third Amended and Restated Certificate of Incorporation of the Company (Incorporated by reference to Exhibit 3.1 to the Company's Quarterly Report on Form 10-Q filed on June 16, 2022 (File No. 001-41374))</u>](https://www.sec.gov/Archives/edgar/data/1835597/000095017022011719/pepg-ex3_1.htm). |
| 4.2 | [<u>Certificate of Correction to Third Amended and Restated Certificate of Incorporation of the Company (Incorporated by reference to Exhibit 3.2 to the Company's Quarterly Report on Form 10-Q filed on November 10, 2022 (File No. 001-41374)).</u>](https://www.sec.gov/Archives/edgar/data/1835597/000095017022024186/pepg-ex3_2.htm) |
| 4.3 | [<u>Certificate of Amendment to the Third Amended and Restated Certificate of Incorporation of PepGen Inc. (Incorporated by reference to Exhibit 3.1 to the Company's Current Report on Form 8-K filed on June 20, 2024 (File No. 001-41374))</u>](https://www.sec.gov/Archives/edgar/data/1835597/000119312524164587/d660943dex31.htm). |
| 4.4 | [<u>Second Amended and Restated By-laws of the Company (Incorporated by reference to Exhibit 3.1 to the Company's Current Report on Form 8-K filed on March 15, 2024 (File No. 001-41374))</u>](https://www.sec.gov/Archives/edgar/data/1835597/000119312524069110/d810119dex31.htm).  |
| 4.5 | [<u>Amended and Restated Investors' Rights Agreement among the Company and certain of its stockholders, dated July 30, 2021 (Incorporated by reference to Exhibit 4.1 to the Registrant's Company's Statement on Form S-1, as amended (File No. 333-264335))</u>](https://www.sec.gov/Archives/edgar/data/1835597/000119312522106884/d235586dex41.htm). |
| 5.1<br> \*  | [<u>Opinion of Goodwin Procter LLP.</u>](pepg-ex5_1.htm) |
| 23.1<br> \*  | [<u>Consent of KPMG LLP, Independent Registered Public Accounting Firm.</u>](pepg-ex23_1.htm) |
| 23.2<br> \*  | [<u>Consent of Goodwin Procter LLP (included in Exhibit 5.1).</u>](pepg-ex5_1.htm) |
| 24.1<br> \*  | [<u>Power of Attorney (included on signature page).</u>](#poa) |
| 99.1 | [<u>2022 Stock Option and Incentive Plan and form of award agreements thereunder (Incorporated by reference to Exhibit 10.2 to the Company's Registration Statement on Form S-1, as amended (File No. 333-264335))</u>](https://www.sec.gov/Archives/edgar/data/1835597/000119312522135245/d235586dex102.htm).  |
| 99.2 | [<u>2022 Employee Stock Purchase Plan (Incorporated by reference to Exhibit 10.3 to the Company's Registration Statement on Form S-1, as amended (File No. 333-264335))</u>](https://www.sec.gov/Archives/edgar/data/1835597/000119312522135245/d235586dex103.htm). |
| 99.3 | [<u>Form of Non-Qualified Stock Option Agreement for Non-Employee Directors (Incorporated by reference to Exhibit 10.2 to the Company's Quarterly Report on Form 10-Q filed on August 7, 2025 (File No. 001-41374)</u>](https://www.sec.gov/Archives/edgar/data/1835597/000119312525174979/pepg-ex10_2.htm). |
| 107<br> \*  | [<u>Filing Fee Table</u>](pepg-exfiling_fees.htm) |
| \* | Filed herewith. |

---

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**SIGNATURES** 

Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Boston, State of Massachusetts, on this 4th day of March, 2026.

---

| | |
|:---|:---|
| **PEPGEN INC.** | **PEPGEN INC.** |
| By: | /s/ James McArthur |
|  | James McArthur, Ph.D. <br>President and Chief Executive Officer |

---

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**POWER OF ATTORNEY AND SIGNATURES**

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints James McArthur, his true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution for him and in his name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement on Form S-8, and to file the same, with all exhibits thereto, and all other documents in connection therewith, with the Securities and Exchange Commission, granting unto each said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that each of said attorney-in-fact or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities indicated as of March 4, 2026:

---

| | |
|:---|:---|
| **Name** | **Title** |
| /s/ James McArthur | Chief Executive Officer<br>(Principal Executive Officer) |
| **James McArthur, Ph. D.** |  |
| /s/ Noel Donnelly | Chief Financial Officer<br>(Principal Financial Officer and Principal Accounting Officer) |
| **Noel Donnelly, M.B.A.** |  |
| /s/ Laurie B. Keating | Chair of the Board of Directors |
| **Laurie B. Keating, J.D.** |  |
| /s/ Habib Joseph Dable | Director |
| **Habib Joseph Dable** |  |
| /s/ Heidi Henson | Director |
| **Heidi Henson** |  |
| /s/ Howard Mayer | Director |
| **Howard Mayer, M.D.** |  |
| /s/ Joshua Resnick. | Director |
| **Joshua Resnick, M.D., M.B.A** |  |
| /s/ Mitchell H. Finer | Director |
| **Mitchell H. Finer, Ph.D.** |  |
| /s/ Lisa Wyman | Director |
| **Lisa Wyman, M.S.** |  |

---

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## Exhibit 5.1

March 4, 2026

PepGen Inc.

321 Harrison Avenue

Boston, MA 02118

Re: <u>Securities Being Registered under Registration Statement on Form S-8</u>

We have acted as your counsel in connection with your filing of a Registration Statement on Form S-8 (the "Registration Statement") pursuant to the Securities Act of 1933, as amended (the "Securities Act"), on or about the date hereof relating to an aggregate of 4,121,747 shares (the "Shares") of Common Stock, par value $0.0001 per share ("Common Stock"), of PepGen Inc., a Delaware corporation (the "Company"), that may be issued pursuant to the Company's 2022 Stock Option and Incentive Plan and 2022 Employee Stock Purchase Plan (collectively, the "Plans").

We have reviewed such documents and made such examination of law as we have deemed appropriate to give the opinion set forth below. We have relied, without independent verification, on certificates of public officials and, as to matters of fact material to the opinion set forth below, on certificates of officers of the Company.

For purposes of the opinion set forth below, we have assumed that, at the time Shares are issued, the total number of then unissued Shares, when added to the number of shares of Common Stock issued, subscribed for, or otherwise committed to be issued, does not exceed the number of shares of Common Stock authorized by the Company's certificate of incorporation.

The opinion set forth below is limited to the Delaware General Corporation Law.

Based on the foregoing, we are of the opinion that the Shares have been duly authorized and, when delivered against payment therefor in accordance with the terms of the Plans, will be validly issued, fully paid and nonassessable.

This opinion letter and the opinion it contains shall be interpreted in accordance with the Core Opinion Principles as published in 74 *Business Lawyer* 815 (Summer 2019).

We hereby consent to the inclusion of this opinion as Exhibit 5.1 to the Registration Statement. In giving our consent, we do not admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations thereunder.

Very truly yours,

/s/ Goodwin Procter LLP

GOODWIN PROCTER LLP

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## Exhibit 23.1

**Consent of Independent Registered Public Accounting Firm**

We consent to the use of our report dated March 4, 2026, with respect to the consolidated financial statements of PepGen Inc., incorporated herein by reference.

/s/ KPMG LLP

San Diego, California

March 4, 2026

------

## Ex-Filing

?xml version='1.0' encoding='ASCII'? EX-FILING FEES

---

| |
|:---|
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Calculation of Filing Fee Tables**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **S-8**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **PepGen Inc.**  |

---

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| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Security Type**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Security Class Title**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Fee Calculation Rule**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Amount Registered**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Proposed Maximum Offering Price Per Unit**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Maximum Aggregate Offering Price**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Fee Rate**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Amount of Registration Fee**  |
| 1 | Equity | Common Stock, $0.0001 par value per share | Other | 3443747 | $6.15 | $21179044.05 | 0.0001381 | $2924.83 |
| 2 | Equity | Common Stock, $0.0001 par value per share | Other | 678000 | $5.23 | $3545940.00 | 0.0001381 | $489.69 |
| Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: |  | $24724984.05  |  | $3414.52  |
| Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  |  |  |  | $0.00  |
| Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  |  |  |  | $3414.52  |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Offering Note** <br>

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <sup>1</sup> (1) Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement on Form S-8 ('Registration Statement') shall also cover any additional shares of common stock, $0.0001 par value per share (the "Common Stock") of PepGen Inc. (the "Registrant") that become issuable under the PepGen Inc. 2022 Stock Option and Incentive Plan (the "2022 Plan") and the PepGen Inc. 2022 Employee Stock Purchase Plan (the "2022 ESPP") by reason of any stock dividend, stock split, recapitalization or any other similar transactions. (2) Represents an additional 3,443,747 shares of Common Stock reserved for issuance under the 2022 Plan as a result of an automatic increase effective January 1, 2026. Shares available for issuance under the 2022 Plan were previously registered on a Registration Statements on Form S-8 filed with the United States Securities and Exchange Commission ("SEC") on May 10, 2022 (File No. 333-264822), March 23, 2023 (File No. 333-270790), March 6, 2024 (File No. 333-277708) and February 24, 2025 (File No. 333-285166). (3) Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457 of the Securities Act, and based on $6.15, the average of the high and low sale prices of the Common Stock as reported on Nasdaq Global Select Market on February 27, 2026 (such date being within five business days of the date that this Registration Statement was filed with the SEC).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <sup>2</sup> (1) Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement on Form S-8 ("Registration Statement") shall also cover any additional shares of common stock, $0.0001 par value per share (the "Common Stock") of PepGen Inc. (the "Registrant") that become issuable under the PepGen Inc. 2022 Stock Option and Incentive Plan (the "2022 Plan") and the PepGen Inc. 2022 Employee Stock Purchase Plan (the "2022 ESPP") by reason of any stock dividend, stock split, recapitalization or any other similar transactions. (4) Represents an additional 678,000 shares of Common Stock reserved for future issuance under the 2022 ESPP as a result of an automatic increase effective January 1, 2026. Shares available for issuance under the 2025 ESPP were previously registered on a Registration Statements on Form S-8 filed with the SEC on May 10, 2022 (File No. 333-264822), March 23, 2023 (File No. 333-270790), March 6, 2024 (File No. 333-277708) and February 24, 2025 (File No. 333-285166). (5) Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457 of the Securities Act, and based on 85% (the percentage of the price per share applicable to purchases under the 2022 ESPP) of $6.15, the average of the high and low sale prices of the Common Stock as reported on Nasdaq Global Select Market on February 27, 2026 (such date being within five business days of the date that this Registration Statement was filed with the SEC).

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| | |
|:---|:---|
| | |
| **Rule 457(p)** | **Rule 457(p)** |
| Fee Offset Claims | N/A |
| Fee Offset Sources | N/A |

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