# EDGAR Filing Document

**Accession Number:** 0001709626
**File Stem:** 0001193125-25-143692
**Filing Date:** 2025-6
**Character Count:** 2329
**Document Hash:** ae3f4dcb4d9ab80df546655b56c6b693
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-25-143692.hdr.sgml**: 20250724

**ACCESSION NUMBER**: 0001193125-25-143692

**CONFORMED SUBMISSION TYPE**: CORRESP

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20250620

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** NuCana plc
- **CENTRAL INDEX KEY:** 0001709626
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** X0
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** CORRESP

**BUSINESS ADDRESS:**
- **STREET 1:** 3 LOCHSIDE WAY
- **CITY:** EDINBURGH
- **STATE:** X0
- **ZIP:** EH12 9DT
- **BUSINESS PHONE:** 44-0-131-357-1111

**MAIL ADDRESS:**
- **STREET 1:** 3 LOCHSIDE WAY
- **CITY:** EDINBURGH
- **STATE:** X0
- **ZIP:** EH12 9DT

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** NuCana BioMed Ltd
- **DATE OF NAME CHANGE:** 20170619

**NUCANA PLC** 

**3 Lochside Way** 

**Edinburgh, EH12 9DT** 

**United Kingdom** 

June 20, 2025

VIA EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

Office of Life Sciences

100 F Street, N.E. Washington, D.C. 20549

Attention: Chris Edwards

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| | |
|:---|:---|
| **Re:** | **NuCana plc**  |

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**Registration Statement on Form F-3, as amended** 

**File No. 333-281576 (the "Registration Statement")** 

**<u>Acceleration Request</u>** 

Ladies and Gentlemen:

In accordance with Rule 461 of the Rules and Regulations promulgated under the Securities Act of 1933, as amended, NuCana plc (the "Registrant") hereby respectfully requests that the Securities and Exchange Commission accelerate the effective date of the above-referenced Registration Statement to Tuesday, June 24, 2025, at 4:00 p.m., Eastern Time, or as soon as thereafter practicable.

The cooperation of the staff in meeting the timetable described above is very much appreciated.

Please contact John T. Rudy of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., counsel to the Registrant, at (617) 348-3050 with any questions regarding this request.

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| |
|:---|
|  Very truly yours, |
|  NUCANA PLC |
|  /s/ Hugh S. Griffith |
|  Hugh S. Griffith<br> Chief Executive Officer |

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cc: *<u>Mintz, Levin, Cohn, Ferris, Glovsky and Popeo,</u> <u>P.C.</u>*

John T. Rudy, Esq.