# EDGAR Filing Document

**Accession Number:** 0001552740
**File Stem:** 0000940400-26-020386
**Filing Date:** 2026-5
**Character Count:** 21457
**Document Hash:** fe7e116fd375d123293b2db0b8547489
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000940400-26-020386.hdr.sgml**: 20260521

**ACCESSION NUMBER**: 0000940400-26-020386

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20260331

**FILED AS OF DATE**: 20260521

**DATE AS OF CHANGE**: 20260521

**PERIOD START**: 20260331

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** FIRST TRUST EXCHANGE-TRADED FUND VI
- **CENTRAL INDEX KEY:** 0001552740

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** MA

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-22717
- **FILM NUMBER:** 261007591

**BUSINESS ADDRESS:**
- **STREET 1:** 120 EAST LIBERTY DRIVE, SUITE 400
- **CITY:** WHEATON
- **STATE:** IL
- **ZIP:** 60187
- **BUSINESS PHONE:** 630-765-8000

**MAIL ADDRESS:**
- **STREET 1:** 120 EAST LIBERTY DRIVE, SUITE 400
- **CITY:** WHEATON
- **STATE:** IL
- **ZIP:** 60187

## Series and Classes Contracts Data

### First Trust Nasdaq Pharmaceuticals ETF (Series ID: S000053945)

| Class ID   | Class Name                             | Ticker Symbol   |
|:---|:---|:---|
| C000169747 | First Trust Nasdaq Pharmaceuticals ETF | FTXH            |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** First Trust Exchange-Traded Fund VI

- **b. Investment Company Act file number:** 811-22717

- **c. CIK number of Registrant:** 0001552740

- **d. LEI of Registrant:** 549300ZLB3EUU3H8NE60

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 120 East Liberty Drive

  - **City:** Wheaton

  - **State:** IL

  - **Foreign country:** US

  - **Zip / Postal Code:** 60187

  - **Telephone number:** 630-765-8000

**Item A.2. Information about the Series.**

- **a. Name of Series:** First Trust Nasdaq Pharmaceuticals ETF

- **b. EDGAR series identifier (if any):** S000053945

- **c. LEI of Series:** 549300YM82DADOQT2M68

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2026-03-31

- **b. Date as of which information is reported:** 2026-03-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $29190055.33

**Total Liabilities:** $14720.32

**Net Assets:** $29175335.01

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000169747 | 3.04%                | 5.04%                | -3.54%               |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $0.00                    | $606980.17                                 |
| Month 2  | $0.00                    | $1284645.99                                |
| Month 3  | $-1067440.25             | $-25338.68                                 |

### Schedule of Portfolio Investments

| Name                                           | Title                                               | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Amneal Pharmaceuticals Inc                     | Amneal Pharmaceuticals Inc COM STK CL A             | CUSIP: 03168L105<br>LEI: 549300VV176ZO5WQHZ61 | Long             | EC               | CORP              | US        |     12984 | NS      | $161391.12    | 0.55%             |  |  |  | No            |                  1 | On Loan: No      |
| Dreyfus Government Cash Management Funds       | Dreyfus Government Cash Management Funds SH BEN INT | CUSIP: 262006208<br>LEI: 549300F7IDB6WRO7VJ11 | Long             | STIV             | RF                | US        |     32295 | NS      | $32294.83     | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Supernus Pharmaceuticals, Inc                  | Supernus Pharmaceuticals, Inc COM                   | CUSIP: 868459108<br>LEI: 549300GRM36VBKISYJ58 | Long             | EC               | CORP              | US        |      2776 | NS      | $143491.44    | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Regeneron Pharmaceuticals, Inc.                | Regeneron Pharmaceuticals, Inc. COM                 | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |      1413 | NS      | $1091740.32   | 3.74%             |  |  |  | No            |                  1 | On Loan: No      |
| Bristol-Myers Squibb Company                   | Bristol-Myers Squibb Company COM                    | CUSIP: 110122108<br>LEI: HLYYNH7UQUORYSJQCN42 | Long             | EC               | CORP              | US        |     35422 | NS      | $2148344.30   | 7.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Tarsus Pharmaceuticals Inc                     | Tarsus Pharmaceuticals Inc COM                      | CUSIP: 87650L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2012 | NS      | $141141.80    | 0.48%             |  |  |  | No            |                  1 | On Loan: No      |
| Moderna Inc                                    | Moderna Inc COM                                     | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |      2836 | NS      | $144068.80    | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| ARCUTIS BIOTHERAPEUTICS INC                    | Arcutis Biotherapeutics Inc. COM                    | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5633 | NS      | $132713.48    | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| 10X Genomics Inc                               | 10X Genomics Inc CL A COM                           | CUSIP: 88025U109<br>LEI: 5493003Z6741WNLG7H43 | Long             | EC               | CORP              | US        |      6591 | NS      | $139926.93    | 0.48%             |  |  |  | No            |                  1 | On Loan: No      |
| Zoetis Inc.                                    | Zoetis Inc. CL A                                    | CUSIP: 98978V103<br>LEI: 549300HD9Q1LOC9KLJ48 | Long             | EC               | CORP              | US        |      8426 | NS      | $996037.46    | 3.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Alkermes PLC                                   | Alkermes PLC SHS                                    | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | IE        |      8380 | NS      | $296316.80    | 1.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Roivant Sciences Ltd                           | Roivant Sciences Ltd SHS                            | CUSIP: 000000000<br>LEI: 549300DL466NY5J6U724 | Long             | EC               | CORP              | BM        |      5250 | NS      | $145425.00    | 0.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals Inc.                   | Alnylam Pharmaceuticals Inc. COM                    | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |       456 | NS      | $150876.72    | 0.52%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences Inc                     | Neurocrine Biosciences Inc COM                      | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |      2630 | NS      | $346476.20    | 1.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Charles River Laboratories International, Inc. | Charles River Laboratories International, Inc. COM  | CUSIP: 159864107<br>LEI: 549300BSQ0R4UZ5KX287 | Long             | EC               | CORP              | US        |      2127 | NS      | $366907.50    | 1.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Twist Bioscience Corporation                   | Twist Bioscience Corporation COM                    | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |      3238 | NS      | $153869.76    | 0.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Krystal Biotech Inc                            | Krystal Biotech Inc COM                             | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |       551 | NS      | $142334.32    | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| United Therapeutics Corporation                | United Therapeutics Corporation COM                 | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |      1630 | NS      | $966557.40    | 3.31%             |  |  |  | No            |                  1 | On Loan: No      |
| Pfizer Inc.                                    | Pfizer Inc. COM                                     | CUSIP: 717081103<br>LEI: 765LHXWGK1KXCLTFYQ30 | Long             | EC               | CORP              | US        |     39951 | NS      | $1121824.08   | 3.85%             |  |  |  | No            |                  1 | On Loan: No      |
| Elanco Animal Health Inc                       | Elanco Animal Health Inc COM                        | CUSIP: 28414H103<br>LEI: 549300SHPNDCE059M934 | Long             | EC               | CORP              | US        |     10925 | NS      | $261435.25    | 0.90%             |  |  |  | No            |                  1 | On Loan: No      |
| Acadia Pharmaceuticals Inc                     | Acadia Pharmaceuticals Inc COM                      | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |      6186 | NS      | $137700.36    | 0.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen Inc                                     | Biogen Inc COM                                      | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |      5759 | NS      | $1055797.47   | 3.62%             |  |  |  | No            |                  1 | On Loan: No      |
| Mirum Pharmaceuticals Inc.                     | Mirum Pharmaceuticals Inc. COM                      | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |      1646 | NS      | $152057.48    | 0.52%             |  |  |  | No            |                  1 | On Loan: No      |
| Travere Therapeutics Inc                       | Travere Therapeutics Inc COM                        | CUSIP: 89422G107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5100 | NS      | $151521.00    | 0.52%             |  |  |  | No            |                  1 | On Loan: No      |
| Amgen Inc.                                     | Amgen Inc. COM                                      | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |      2846 | NS      | $1001365.10   | 3.43%             |  |  |  | No            |                  1 | On Loan: No      |
| Exelixis, Inc.                                 | Exelixis, Inc. COM                                  | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |     10279 | NS      | $440866.31    | 1.51%             |  |  |  | No            |                  1 | On Loan: No      |
| Protagonist Therapeutics Inc                   | Protagonist Therapeutics Inc COM                    | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1650 | NS      | $173910.00    | 0.60%             |  |  |  | No            |                  1 | On Loan: No      |
| Cardinal Health, Inc.                          | Cardinal Health, Inc. COM                           | CUSIP: 14149Y108<br>LEI: CCU46N3GJMF4OK4N7U60 | Long             | EC               | CORP              | US        |      4819 | NS      | $1018302.89   | 3.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Viatris Inc                                    | Viatris Inc COM                                     | CUSIP: 92556V106<br>LEI: 254900ZZTSW7NL773X71 | Long             | EC               | CORP              | US        |     73989 | NS      | $999591.39    | 3.43%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC Therapeutics, Inc.                         | PTC Therapeutics, Inc. COM                          | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |      5449 | NS      | $371240.37    | 1.27%             |  |  |  | No            |                  1 | On Loan: No      |
| Eli Lilly & Co.                                | Eli Lilly & Co. COM                                 | CUSIP: 532457108<br>LEI: FRDRIPF3EKNDJ2CQJL29 | Long             | EC               | CORP              | US        |      2100 | NS      | $1931517.00   | 6.62%             |  |  |  | No            |                  1 | On Loan: No      |
| Arrowhead Pharmaceuticals Inc                  | Arrowhead Pharmaceuticals Inc COM                   | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |      2611 | NS      | $163709.70    | 0.56%             |  |  |  | No            |                  1 | On Loan: No      |
| Biomarin Pharmaceutical Inc.                   | Biomarin Pharmaceutical Inc. COM                    | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |      6318 | NS      | $356903.82    | 1.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals Incorporated            | Vertex Pharmaceuticals Incorporated COM             | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |      2223 | NS      | $992658.42    | 3.40%             |  |  |  | No            |                  1 | On Loan: No      |
| Incyte Corporation.                            | Incyte Corporation. COM                             | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |      6843 | NS      | $644063.16    | 2.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Spyre Therapeutics Inc                         | Spyre Therapeutics Inc COM NEW                      | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |      3533 | NS      | $178204.52    | 0.61%             |  |  |  | No            |                  1 | On Loan: No      |
| Catalyst Pharmaceuticals Inc.                  | Catalyst Pharmaceuticals Inc. COM                   | CUSIP: 14888U101<br>LEI: 5299004O0R5XXLA5H544 | Long             | EC               | CORP              | US        |      6583 | NS      | $162995.08    | 0.56%             |  |  |  | No            |                  1 | On Loan: No      |
| Merck & Co., Inc                               | Merck & Co., Inc COM                                | CUSIP: 58933Y105<br>LEI: 4YV9Y5M8S0BRK1RP0397 | Long             | EC               | CORP              | US        |     17843 | NS      | $2146334.47   | 7.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Jazz Pharmaceuticals PLC                       | Jazz Pharmaceuticals PLC SHS USD                    | CUSIP: 000000000<br>LEI: 635400GAUMJCLEZRRV50 | Long             | EC               | CORP              | IE        |      3347 | NS      | $632750.35    | 2.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Illumina Inc                                   | Illumina Inc COM                                    | CUSIP: 452327109<br>LEI: SQ95QG8SR5Q56LSNF682 | Long             | EC               | CORP              | US        |      3657 | NS      | $450761.82    | 1.55%             |  |  |  | No            |                  1 | On Loan: No      |
| Halozyme Therapeutics Inc                      | Halozyme Therapeutics Inc COM                       | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |      5005 | NS      | $323473.15    | 1.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Ionis Pharmaceuticals, Inc.                    | Ionis Pharmaceuticals, Inc. COM                     | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |      1872 | NS      | $140568.48    | 0.48%             |  |  |  | No            |                  1 | On Loan: No      |
| TG Therapeutics Inc                            | TG Therapeutics Inc COM                             | CUSIP: 88322Q108<br>LEI: 529900X21UKABN9NJ529 | Long             | EC               | CORP              | US        |      5049 | NS      | $167727.78    | 0.57%             |  |  |  | No            |                  1 | On Loan: No      |
| Kymera Therapeutics Inc                        | Kymera Therapeutics Inc COM                         | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1663 | NS      | $138511.27    | 0.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Guardant Health Inc                            | Guardant Health Inc COM                             | CUSIP: 40131M109<br>LEI: 254900M8C3E5VC8BR186 | Long             | EC               | CORP              | US        |      1618 | NS      | $149454.66    | 0.51%             |  |  |  | No            |                  1 | On Loan: No      |
| Ligand Pharmaceuticals Incorporated            | Ligand Pharmaceuticals Incorporated COM NEW         | CUSIP: 53220K504<br>LEI: 5493008K7TB0IKP37H79 | Long             | EC               | CORP              | US        |       766 | NS      | $152931.90    | 0.52%             |  |  |  | No            |                  1 | On Loan: No      |
| Johnson & Johnson                              | Johnson & Johnson COM                               | CUSIP: 478160104<br>LEI: 549300G0CFPGEF6X2043 | Long             | EC               | CORP              | US        |      8893 | NS      | $2173804.92   | 7.45%             |  |  |  | No            |                  1 | On Loan: No      |
| ARCUS BIOSCIENCES INC                          | Arcus Biosciences Inc. COM                          | CUSIP: 03969F109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7459 | NS      | $161114.40    | 0.55%             |  |  |  | No            |                  1 | On Loan: No      |
| Gilead Sciences Inc.                           | Gilead Sciences Inc. COM                            | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |      7416 | NS      | $1033567.92   | 3.54%             |  |  |  | No            |                  1 | On Loan: No      |
| AbbVie Inc.                                    | AbbVie Inc. COM                                     | CUSIP: 00287Y109<br>LEI: FR5LCKFTG8054YNNRU85 | Long             | EC               | CORP              | US        |      9520 | NS      | $2070504.80   | 7.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Medpace Holdings Inc.                          | Medpace Holdings Inc. COM                           | CUSIP: 58506Q109<br>LEI: 549300H8TYEUVTW14A54 | Long             | EC               | CORP              | US        |       865 | NS      | $415364.35    | 1.42%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2026-05-21

**Name of Applicant:** First Trust Exchange-Traded Fund VI

**Signature:** Derek Maltbie

**Name of Signer:** Derek Maltbie

**Title:** Treasurer, Chief Financial Officer and Chief Accounting Officer