# EDGAR Filing Document

**Accession Number:** 0001580465
**File Stem:** 0001209191-23-006844
**Filing Date:** 2023-2
**Character Count:** 8542
**Document Hash:** 5badd644a2144ed3850d82b5b8cb59b5
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001209191-23-006844.hdr.sgml**: 20230203

**ACCESSION NUMBER**: 0001209191-23-006844

**CONFORMED SUBMISSION TYPE**: 3

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20230201

**FILED AS OF DATE**: 20230203

**DATE AS OF CHANGE**: 20230203

**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Spada Alfred P.
- **CENTRAL INDEX KEY:** 0001580465

**FILING VALUES:**
- **FORM TYPE:** 3
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-36003
- **FILM NUMBER:** 23586096

**MAIL ADDRESS:**
- **STREET 1:** C/O CONATUS PHARMACEUTICALS INC.
- **STREET 2:** 4365 EXECUTIVE DRIVE, SUITE 200
- **CITY:** SAN DIEGO
- **STATE:** CA
- **ZIP:** 92121
**ISSUER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Histogen Inc.
- **CENTRAL INDEX KEY:** 0001383701
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 203183915
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**BUSINESS ADDRESS:**
- **STREET 1:** 10655 SORRENTO VALLEY ROAD
- **STREET 2:** SUITE 200
- **CITY:** San Diego
- **STATE:** CA
- **ZIP:** 92121
- **BUSINESS PHONE:** (858) 526-3100

**MAIL ADDRESS:**
- **STREET 1:** 10655 SORRENTO VALLEY ROAD
- **STREET 2:** SUITE 200
- **CITY:** San Diego
- **STATE:** CA
- **ZIP:** 92121

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Conatus Pharmaceuticals Inc.
- **DATE OF NAME CHANGE:** 20140729

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Conatus Pharmaceuticals Inc
- **DATE OF NAME CHANGE:** 20061214

## Ex-24

```

POWER OF ATTORNEY

Know all by these presents, that the undersigned hereby constitutes and appoints
each of Steven J. Mento, Ph.D. and Susan A. Knudson, signing singly, the
undersigned's true and lawful attorney-in-fact to:

(1)	prepare, execute in the undersigned's name and on the undersigned's behalf,
and submit to the U.S. Securities and Exchange Commission (the "SEC") a Form ID,
including any amendments thereto, and any other documents necessary or
appropriate to obtain codes and passwords enabling the undersigned to make
electronic filings with the SEC of reports required by Section 16(a) of the
Securities Exchange Act of 1934, as amended (together with the rules and
regulations of the SEC promulgated thereunder, the "Exchange Act");

(2)	execute for and on behalf of the undersigned, in the undersigned's capacity
as a director of the Histogen Inc. (the "Company") or its subsidiaries, Forms 3,
4 and 5 in accordance with Section 16(a) of the Exchange Act;

(3)	do and perform any and all acts for and on behalf of the undersigned which
may be necessary or desirable to complete and execute any such Form 3, 4 or 5,
complete and execute any amendment or amendments thereto, and timely file such
form with the SEC and any stock exchange or similar authority; and

(4)	take any other action of any type whatsoever in connection with the
foregoing which, in the opinion of such attorney-in-fact, may be of benefit to,
in the best interest of, or legally required by, the undersigned, it being
understood that the documents executed by such attorney-in-fact on behalf of the
undersigned pursuant to this Power of Attorney shall be in such form and shall
contain such terms and conditions as such attorney- in-fact may approve in such
attorney-in-fact's discretion.

The undersigned hereby grants to each such attorney-in-fact full power and
authority to do and perform any and every act and thing whatsoever requisite,
necessary, or proper to be done in the exercise of any of the rights and powers
herein granted, as fully to all intents and purposes as the undersigned might or
could do if personally present, with full power of substitution or revocation,
hereby ratifying and confirming all that such attorney-in-fact, or such
attorney- in-fact's substitute or substitutes, shall lawfully do or cause to be
done by virtue of this Power of Attorney and the rights and powers herein
granted. The undersigned acknowledges that the foregoing attorneys-in-fact, in
serving in such capacity at the request of the undersigned, are not assuming,
nor is the Company assuming, any of the undersigned's responsibilities to comply
with Section 16 of the Exchange Act.

This Power of Attorney shall remain in full force and effect until the earliest
to occur of: (i) the date the undersigned is no longer required to file Forms 3,
4 and 5 with respect to the undersigned's holdings of and transactions in
securities issued by the Company; and (ii) the revocation hereof by the
undersigned in a signed writing delivered to the foregoing attorneys-in-fact.
This Power of Attorney revokes all prior Powers of Attorney relating to
reporting under Section 16 of the Exchange Act of holdings of and transactions
in the Company's securities.

This Power of Attorney may be executed by electronic signature (including any
electronic signature complying with the ESIGN Act of 2000, such as
www.docusign.com) and/or delivered by electronic transmission, including by
facsimile or electronic mail, and when so executed and/or delivered shall have
been duly and validly executed and/or delivered, and be valid and effective, for
all purposes.

[ the signature page follows ]

IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be
executed as of this February 3, 2023.

 	            	/s/  Alfred P. Spada, Ph.D.
  		       Name: Alfred P. Spada, Ph.D.

```

### UNITED STATES SECURITIES AND EXCHANGE COMMISSION
**Washington, D.C. 20549**

## FORM 3

### INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Spada Alfred P.<br><sub>(Last) (First) (Middle)</sub><br>C/O HISTOGEN INC.<br>10655 SORRENTO VALLEY ROAD, SUITE 200<br><sub>(Street)</sub><br>SAN DIEGO, CA 92121<br><sub>(City) (State) (Zip)</sub> | **3. Issuer Name and Ticker or Trading Symbol**<br>Histogen Inc. [ HSTO ] | **5. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  |
| **2. Date of Event Requiring Statement (Month/Day/Year)**<br>2023-02-01 | **4. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[ ] Director   [ ] 10% Owner<br>[X] Officer (give title below)   [ ] Other (specify below)<br>_See Remarks_ | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[X] Form filed by One Reporting Person<br>[ ] Form filed by More than One Reporting Person |

---

## Table I - Non-Derivative Securities Beneficially Owned

---

|  |  |  |  |
| --- | --- | --- | --- |
| 1. Title of Security | 2. Amount of Securities Beneficially Owned | 3. Ownership Form | 4. Nature of Indirect Beneficial Ownership |
| Common Stock | 979 | D |  |
| Common Stock | 1235 | I | See footnote<sup>(1)</sup> |

---

## Table II - Derivative Securities Beneficially Owned

---

|  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- |
| 1. Title of Derivative Security | 2. Date Exercisable and Expiration Date (Month/Day/Year) | 2. Date Exercisable and Expiration Date (Month/Day/Year) | 3. Title and Amount of Underlying Securities | 3. Title and Amount of Underlying Securities | 4. Conversion or Exercise Price | 5. Ownership Form | 6. Nature of Indirect Beneficial Ownership |
| 1. Title of Derivative Security | Date Exercisable | Expiration Date | Title | Amount or Number of Shares | 4. Conversion or Exercise Price | 5. Ownership Form | 6. Nature of Indirect Beneficial Ownership |
|  |  |  |  |  |  |  |  |

---

### Footnotes:

(1) Held by a family trust of which Dr. Spada is a trustee.

**Remarks:**
Executive Vice President and Chief Scientific Officer

**Signature:** /s/  Susan A. Knudson as attorney-in-fact for Alfred P. Spada, Ph.D.  
**Date:** 2023-02-03

### Remarks:

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

**Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.**