# EDGAR Filing Document

**Accession Number:** 0001671927
**File Stem:** 0001140361-23-001346
**Filing Date:** 2023-1
**Character Count:** 28195
**Document Hash:** eeb3e510ea1867b7731a2d2e4b16780f
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001140361-23-001346.hdr.sgml**: 20230111

**ACCESSION NUMBER**: 0001140361-23-001346

**CONFORMED SUBMISSION TYPE**: 6-K

**PUBLIC DOCUMENT COUNT**: 34

**CONFORMED PERIOD OF REPORT**: 20230111

**FILED AS OF DATE**: 20230111

**DATE AS OF CHANGE**: 20230111

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Immunocore Holdings plc
- **CENTRAL INDEX KEY:** 0001671927
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** X0
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 6-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-39992
- **FILM NUMBER:** 23523784

**BUSINESS ADDRESS:**
- **STREET 1:** 90 PARK DRIVE
- **STREET 2:** MILTON PARK, ABINGDON
- **CITY:** OXFORDSHIRE
- **STATE:** X0
- **ZIP:** OX14 4RY
- **BUSINESS PHONE:** 01235 5430281

**MAIL ADDRESS:**
- **STREET 1:** 90 PARK DRIVE
- **STREET 2:** MILTON PARK, ABINGDON
- **CITY:** OXFORDSHIRE
- **STATE:** X0
- **ZIP:** OX14 4RY

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Immunocore Ltd
- **DATE OF NAME CHANGE:** 20160412

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### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION

#### Washington, D.C. 20549

#### <br>

### FORM 6-K

#### <br>

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#### REPORT OF FOREIGN PRIVATE ISSUER

#### PURSUANT TO RULE 13a-16 OR 15d-16

#### UNDER THE SECURITIES EXCHANGE ACT OF 1934

#### For the Month of January 2023

#### Commission File Number: 001-39992

#### <br>

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## Immunocore Holdings plc

#### (Translation of registrant's name into English)
&nbsp;&nbsp;&nbsp;&nbsp;<br>

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#### <br>

#### 92 Park Drive

#### Milton Park

#### Abingdon, Oxfordshire OX14 4RY

#### United Kingdom

#### (Address of principal executive office)
&nbsp;&nbsp;&nbsp;&nbsp;<br>

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Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F:

☒ Form 20-F ☐ Form 40-F <br>

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#### INCORPORATION BY REFERENCE

The information in this Report on Form 6-K ("Report"), other than Exhibit 99.1 hereto, shall be deemed to be incorporated by reference into the registration statements on Form S-8 (File Nos. 333-255182 and 333-265000) and the registration statement on Form F-3ASR (File No. 333-264105) of Immunocore Holdings plc (the "Company") and to be a part thereof from the date on which this Report is furnished, to the extent not superseded by documents or reports subsequently filed or furnished.

Exhibit 99.1 hereto is being furnished and shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934 (the "Exchange Act") or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933 or the Exchange Act.

#### INFORMATION CONTAINED IN THIS REPORT ON FORM 6-K

#### Presentation at 41st Annual J.P. Morgan Healthcare Conference

On Wednesday, January 11, 2023, Bahija Jallal, the Chief Executive Officer of the Company, presented at the 41st Annual J.P. Morgan Healthcare Conference. The presentation, which was webcasted, is available in the "Investors/Media" section of the Company's website, located at www.immunocore.com. A copy of the presentation is furnished as Exhibit 99.1 and is incorporated herein by reference.

The key highlights from the presentation include the following:

<br> • The Company has added three new ImmTAC product candidates (targeting PRAME-A24, PRAME-A02-HLE (half-life extended), and PIWIL1) to the Company's pipeline.

<br> • As of January 2023, the Company has dosed over 500 cancer patients with KIMMTRAK/tebentafusp for the treatment of metastatic uveal melanoma.

<br> • As of January 2023, KIMMTRAK is approved in over 30 countries, with continued global commercial expansion planned for 2023-2024.

• The Company is starting a Phase 2/3 clinical trial to investigate the potential of tebentafusp for the treatment of advanced cutaneous melanoma. The Company estimates this expansion opportunity would be a potential addressable patient population that is 2-4 times larger than the opportunity for uveal melanoma.

<br> • The Company expects to report initial data from the monotherapy and combination arms of the Phase 1/2 dose escalation trial of IMC-F106C (PRAME-A02) by the first half of 2024.

<br> • The Company believes IMC-R117C is the first PIWIL1 targeted immunotherapy and plans to submit an investigational new drug application in the fourth quarter of 2023.

<br> • The Company plans to report data from the single ascending dose portion of the Phase 1 clinical trial of IMC-M113V, the Company's ImmTAV molecule targeting the human immunodeficiency virus, in 2023.

CAUTIONARY NOTE ON FORWARD-LOOKING STATEMENTS

This Report contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as "may," "will," "expect," "plan," "anticipate," "estimate," "intend" and similar expressions (as well as other words or expressions referencing future events, conditions or circumstances) are intended to identify forward-looking statements. These statements include, but are not limited to, statements regarding the Company's strategic priorities, pipeline and expansion thereof, the therapeutic potential and expected clinical benefits, of the Company's products and product candidates, and the progress, timing, scope, expansion and results of Immunocore's existing and planned clinical trials, including statements regarding continued global commercial expansion of KIMMTRAK, the estimated potential addressable patient population for tebentafusp for the treatment of advanced cutaneous melanoma, the timing for reporting initial data from the monotherapy and combination arms of the Phase 1/2 dose escalation trial of IMC-F106C (PRAME-A02), the Company's belief that IMCR-R117C is the first PIWIL targeted immunotherapy, the timing for submission of an investigational new drug application for IMC-R117C, and the timing for reporting data from the single ascending dose portion of the Phase 1 clinical trial of IMC-M113V. These forward-looking statements are based on the Company's expectations and assumptions as of the date of this Report, and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements, many of which are beyond the Company's control. Actual results may differ materially from those expressed or implied by these forward-looking statements. For a discussion of risk factors that may cause the Company's actual results to differ from those expressed or implied in the forward-looking statements in this Report, you should refer to the Company's filings with the U.S. SEC, including the "Risk Factors" sections contained therein. Except as required by law, the Company undertakes no obligation to publicly update any forward-looking statements, whether as a result of new information, future events or otherwise. You should, therefore, not rely on these forward-looking statements as representing the Company's views as of any date subsequent to the date of this Report.

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#### EXHIBIT INDEX

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| | |
|:---|:---|
| **Exhibit**<br> **No.** | **Description** |
| [99.1](brhc10046543_99-1.htm) | Annual J.P. Morgan Healthcare Conference presentation, dated January 11, 2023. |

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#### SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

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| | | | |
|:---|:---|:---|:---|
|  | **IMMUNOCORE HOLDINGS PLC** | **IMMUNOCORE HOLDINGS PLC** | **IMMUNOCORE HOLDINGS PLC** |
| Date: January 11, 2023 | By: | /s/ Bahija Jallal, Ph.D. | /s/ Bahija Jallal, Ph.D. |
|  |  | Name: | Bahija Jallal, Ph.D. |
|  |  | Title: | Chief Executive Officer |

---

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## Exhibit 99.1

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**Exhibit 99.1**<br>

![](brhc10046543_99-1slide1.jpg)

Transformative Medicines for Patients Bahija Jallal, PhD – Chief Executive Officer 41st Annual J.P. Morgan Healthcare Conference JANUARY 11TH, 2023

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![](brhc10046543_99-1slide33.jpg)

This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as "may," "can," "will," "believe," "expect," "plan," "anticipate", "potential" and similar expressions (as well as other words or expressions referencing future events or circumstances) are intended to identify forward-looking statements. All statements, other than statements of historical facts, included in this presentation are forward-looking statements. These statements include, but are not limited to, statements regarding the marketing, therapeutic potential, and expected clinical benefits, including extended overall survival benefit and reduction in circulating tumor DNA, of Immunocore's products and product candidates; expectations regarding the development of Immunocore's pipeline and the design, progress, timing, enrollment, scope, expansion and results of Immunocore's existing, planned and other future clinical trials and IND enabling studies, including the targeted delivery of IND for three new product candidates, the expansion of, and timing for reporting data from the monotherapy and combination arms of, the PRAME-A02 trial and the initiation of the multiple ascending dose portion of, and timing for reporting data from the single ascending dose portion of, the IMC- M113V Phase 1 HIV clinical trial; the ability of TCR therapeutics to target approximately 90% of the human proteome; statements regarding the durability, efficacy and toleration of Immunocore's product candidates; expectations regarding the commercialization of KIMMTRAK including potential growth opportunities and trends and increasing access to KIMMTRAK; expectations regarding the value proposition of KIMMTRAK in metastatic uveal melanoma (mUM) and advanced melanoma; expectations regarding the potential market size and opportunity for Immunocore's products and product candidates, including statements with respect to potential patient population; expectations regarding the number of patients that PRAME-A02 has the potential to benefit; statements that IMC-R117C is a first-in-class PIWIL1-targeted immunotherapy under development; statements regarding the planned IND timing for IMC-R117C; expectations regarding future milestones; future development plans of tebentafusp and Immunocore's other product candidates; the ability to obtain and maintain regulatory approval for its products and product candidates; expectations regarding the sustained or potential commercial performance and uptake of KIMMTRAK and Immunocore's other product candidates, if approved; expectations regarding Immunocore's management of resources and expected cash runway; and preliminary unaudited net sales and cash and cash equivalents of KIMMTRAK and tebentafusp; and the validation of the ImmTAC platform. These forward-looking statements are based on management's current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially and adversely from those expressed or implied by any forward-looking statements, many of which are beyond Immunocore's control. These include, without limitation, risks and uncertainties related to the impact of worsening macroeconomic conditions and the ongoing and evolving COVID-19 pandemic, the war in Ukraine or global geopolitical tension on Immunocore's business, strategy, clinical trials, financial position and anticipated milestones, including Immunocore's ability to conduct ongoing and planned clinical trials; Immunocore's ability to obtain and maintain regulatory approval of its product candidates; Immunocore's ability to obtain clinical supply of current or future product candidates or commercial supply of KIMMTRAK or any future approved products, including as a result of supply chain disruptions; Immunocore's ability to develop, manufacture and commercialize its product candidates; Immunocore's ability and plans to launch, market and sell KIMMTRAK or any future approved products, to continue to establish and expand a commercial infrastructure; Immunocore's ability to successfully expand the approved indications for KIMMTRAK, or obtain marketing approval for KIMMTRAK in additional geographies in the future; the delay of any current or planned clinical trials, whether due to the COVID- 19 pandemic, patient enrollment delays or otherwise; unexpected safety or efficacy data observed during preclinical studies or clinical trials and Immunocore's ability to successfully demonstrate the safety and efficacy of its product candidates and gain approval of its product candidates on a timely basis, if at all; competition with respect to market opportunities; actions of regulatory agencies, which may affect the initiation, timing and progress of clinical trials or future regulatory approval; Immunocore's ability to obtain, maintain and enforce intellectual property protection for KIMMTRAK or any product candidates it is developing; clinical trial site activation or enrollment rates that are lower than expected; Immunocore's need for and ability to obtain additional funding on favorable terms or at all, including as a result of worsening macroeconomic conditions such as rising inflation and interest rates, volatility in the capital markets and related market uncertainty; and the success of Immunocore's current and future collaborations, partnerships or licensing arrangements. These and other risks and uncertainties are described in greater detail in the section titled 'Risk Factors'; in Immunocore's filings with the Securities and Exchange Commission, including Immunocore's most recent Annual Report on Form 20-F, as supplemented by its most recent filings that Immunocore has made or may make with the SEC in the future. Such risks may be amplified by the COVID-19 pandemic and its potential impact on Immunocore's business and the overall global economy. Any forward-looking statements represent Immunocore's views only as of the date of this presentation and should not be relied upon as representing its views as of any subsequent date. Immunocore does not assume any obligation to update any forward-looking statements, except as may be required by law. In addition, as the reported net sales and cash and cash equivalents in this presentation are preliminary, have not been audited and are subject to change pending completion of our audited financial statements for the year ended December 31, 2022, it is possible that Immunocore or its independent registered public accounting firm may identify items that require Immunocore to make adjustments to the amount included in this presentation, and such changes could be material. Additional information and disclosures would also be required for a more complete understanding of Immunocore's financial position and results of operations as of December 31, 2022. Certain information contained in this presentation relates to or is based on studies, publications, surveys, and other data obtained from third-party sources and Immunocore's own internal estimates and research. While Immunocore believes these third-party sources to be reliable as of the date of this presentation, it has not independently verified, and makes no representation as to the adequacy, fairness, accuracy, or completeness of, any information obtained from third-party sources. KIMMTRAK™ is a trademark owned or licensed to Immunocore. Forward-looking statement 2

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![](brhc10046543_99-1slide3.jpg)

Platform: Differentiated Building a fully integrated sustainable biotechnology company Track record from research to commercialization \* "Net sales" refers to total net product and pre-product revenue of KIMMTRAK and tebentafusp based on December 31, 2022 convenience rate of of £1 to $1.21. Preliminary net sales are approximated and unaudited. 3 Product Two Product Three Product Four Product Five Product Six Preclinic Product One al Phase 1 Phase 2 Phase 3 Pipeline: Sustainable Performance: Proven ~$140m net sales\* Product: First-in-class Pioneering Science

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![](brhc10046543_99-1slide4.jpg)

Our mission To radically improve outcomes for patients with cancer, infectious diseases, and autoimmune conditions by pioneering and delivering transformative medicines 4

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![](brhc10046543_99-1slide5.jpg)

5 Harnessing the immune system to fight disease with targeted, off-the-shelf, bispecific, soluble T cell receptors (TCRs)

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![](brhc10046543_99-1slide6.jpg)

6 TCR therapeutics target >90% of the human proteome

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![](brhc10046543_99-1slide7.jpg)

Our platform is modular Applicable across 3 therapeutic areas 7 Oncology Infectious Diseases Autoimmune Conditions UPREGULATION OF THE IMMUNE SYSTEM DOWNREGULATION OF THE IMMUNE SYSTEM

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![](brhc10046543_99-1slide8.jpg)

Today's presentation will cover oncology and infectious diseases Infectious Diseases 8 Oncology UPREGULATION OF THE IMMUNE SYSTEM Autoimmune Conditions DOWNREGULATION OF THE IMMUNE SYSTEM

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![](brhc10046543_99-1slide9.jpg)

The next chapter in oncology

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![](brhc10046543_99-1slide10.jpg)

We have written the next chapter in cancer treatment 10 T Cell Receptor (TCR) Therapy Off-the-shelf bispecific T cell engagers 1949 Targeted Therapy Chemotherapy 1997 Immunotherapy 2011 Antibody-Drug Conjugate 2013 Cell Therapy 2017 2022

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![](brhc10046543_99-1slide11.jpg)

KIMMTRAK® 11

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![](brhc10046543_99-1slide12.jpg)

12 We are leading the way in TCR therapeutics 1st First and only FDA-approved treatment for metastatic uveal melanoma 1st KIMMTRAK® (tebentafusp-tebn): first approved TCR therapeutic 1st First T-cell engager to show Overall Survival (OS) in solid tumor

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![](brhc10046543_99-1slide13.jpg)

Nathan, P. et. al. New England Journal of Medicine 2021; 385:1196-1206 13 KIMMTRAK prolongs overall survival (Hazard ratio: 0.51) First-in-class, off-the-shelf, bispecific TCR with median OS of 21.7 months Overall Survival benefit in patients treated with KIMMTRAK or investigator's choice in first-line

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![](brhc10046543_99-1slide14.jpg)

Executing on the 2022 global commercial launch of KIMMTRAK 14 ~$50M Preliminary Q4 net sales 30+ Country approvals\* 50% of patients are now first line (1L) ~$140M Preliminary year end net sales >500 patients treated with KIMMTRAK since Phase 3 data 1. "Net sales" refers to total net product and pre-product revenue of KIMMTRAK and tebentafusp based on December 31, 2022 convenience rate of of £1 to $1.21. Preliminary net sales are approximated and unaudited.; 2. including US, UK, Canada, Australia, and countries w/in the EU

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![](brhc10046543_99-1slide15.jpg)

Expanding beyond UM to previously-treated cutaneous melanoma 15 Tebentafusp 1-year OS1 in CM higher than historical benchmark 75% Tebentafusp + checkpoints 55% Historical Benchmark Randomized Phase 2/3 with OS endpoint Primary endpoint: OS vs 2-4X larger potential addressable patient population than uveal melanoma ▸ HLA\*A2:01 ▸ Cutaneous melanoma ▸ Prior anti-PD1 - Progression within 6 months last dose ▸ Prior ipilimumab ▸ Prior TKI (if BRAFm) CM, cutaneous melanoma 1. Middleton et al., ASCO 2022

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![](brhc10046543_99-1slide16.jpg)

PRAME Franchise: A02, A24, A02-HLE

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![](brhc10046543_99-1slide17.jpg)

PRAME-A02 has the potential to benefit ~150k patients annually Tumor type Prevalence of PRAME expression1 HLA\*02:01+, PRAME+ metastatic patients (G7)2 17 PRAME prevalence derived from immunohistochemistry and RTqPCR of patient samples and analysis of TCGA Epidemiology data from cancer registries and Decision Resources, Annual incidence of metastatic patients Endometrial >10K Expressed across multiple 70-100% solid tumors Melanoma >10K Ovarian >15K NSCLC-squamous >30K 50-70% NSCLC-adeno >40K Negative prognostic marker SCLC >15K TNBC >5K SCCHN Gastric Broad and homogeneous 20-50% RCC >30K expression within key tumors Esophageal Cholangiocarcinoma Cervical

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![](brhc10046543_99-1slide18.jpg)

\* Two patients (1 with NSCLC, 1 serous ovarian) discontinued treatment due to PD with scan data not available at DCO ; † This serous ovarian patient (H-score 39) had an unconfirmed partial response (uPR) at the time of the ESMO Congress September 2022 presentation, that was subsequently confirmed. ‡ PRAME expression assessed by IHC H-score; Two PRAME-negative patients both had PD (not shown); Endo, endometrial carcinoma; NSCLC, non small cell lung carcinoma; TNBC, triple-negative breast cancer. Hamid, O., et. al, Annals of Oncology (ESMO 2022) 33 (suppl_7): S331-S355. 18 Responses observed in multiple tumor types IMC-F106C ESMO 2022 Positive Not evaluable PRAME expression‡

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![](brhc10046543_99-1slide19.jpg)

NSCLC, non small cell lung carcinoma Hamid, O., et. al, Annals of Oncology (ESMO 2022) 33 (suppl_7): S331-S355. 19 Majority of patients have durable tumor response or stabilization IMC-F106C ESMO 2022

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![](brhc10046543_99-1slide20.jpg)

Monotherapy activity provides optionality to develop in single arm and randomized trials 20 Enrolling patients globally in adaptive trial with multiple arms P Endometrial Monotherapy expansion Monotherapy IV dose escalation Checkpoint inhibitor combinations ImmTAC combinations Chemotherapy combinations Expanding clinical trial footprint \| Aim to understand breadth of clinical activity in solid tumors M o n o t h e r a p y C o m b i n a t i o n s NSCLC Monotherapy expansion Ovarian Monotherapy expansion Cutaneous melanoma Monotherapy expansion Enables future randomized trials into earlier lines of therapy Adaptive design enables flexible expansion size

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![](brhc10046543_99-1slide21.jpg)

HLE, Half-life extension Expansion of ImmTAC franchise targeting PRAME Building on enthusiasm for IMC-F106C targeting PRAME HLA-A02 IMC-F106C PRAME HLA-A02 TCRxCD3 ▸ Clinically validated ▸ Focus on expanding clinical program IMC-T119C PRAME HLA-A24 TCRxCD3 ▸ Expands potential addressable population by ~30% (G7) ▸ High prevalence in Japan IMC-P115C PRAME HLA-A02 TCRxCD3 HLE ▸ Half-life extended (HLE) for less frequent dosing Target HLA subtype Format

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![](brhc10046543_99-1slide22.jpg)

Novel ImmTAC Candidate for GI cancers from our discovery engine

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![](brhc10046543_99-1slide23.jpg)

PIWIL1, piwi-like protein1, MSS, microsatellite stable; MSI. Microsatellite instability; CRC, colorectal \* Estimated across colorectal, esophageal, gastric, pancreatic, ovarian, endometroid cancers 23 IMC-R117C: A first-in-class immunotherapy targeting PIWIL1 IND planned Q4 2023 Total >35,000\* patients/year positive for PIWIL1 and HLA-A02 PIWIL1 RNA in situ hybridization Normal colon Colon adenocarcinoma PIWIL1 detected Negative prognostic marker in multiple cancers, role in tumor progression Expressed in CRC, historically insensitive to IO, and across major subgroups^ 25% CRC have broad PIWIL1 expression (e.g., > 75% of tumor cells positive)

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![](brhc10046543_99-1slide24.jpg)

Pursuing a functional cure in infectious diseases

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![](brhc10046543_99-1slide25.jpg)

Pursuing a functional cure in HBV & HIV IMC-I109V HBV Phase 1 ▸First cohort (0.8 mcg) reported ▸HBsAg transiently decreased1 ▸Decreases coincided with transient ALT elevations1 Initial Phase 1 SAD data presented at EASL 2022 Congress IMC-M113V HIV Phase 1 ▸Finished single dose escalation and starting Multiple Ascending Dose ▸Initial funding by the Bill & Melinda Gates Foundation2 Phase 1 Single Ascending Dose (SAD) data expected in 2023 1. Bourgeois, et. al. EASL 2022; 2. Program is wholly owned, development costs previously provided by the Bill & Melinda Gate s Foundation (BMGF), Immunocore retains all development and commercialization rights in the developed world.

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![](brhc10046543_99-1slide26.jpg)

Delivering on our promise – Consistent execution

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![](brhc10046543_99-1slide27.jpg)

27 Delivering leading bispecific TCR pipeline Multiple candidates in oncology and infectious diseases O N C O L O G Y INFECTIOUS DISEASES Candidate Target Indication IND-enabling Phase 1 Phase 2 Phase 3 Approved gp100 Uveal melanoma Advanced melanoma Tebentafusp Multiple solid tumors Monotherapy dose explor ation Multiple solid tumors Combinations w/ standar ds of care IMC-F106C PRAME-A02 2L+ cutaneous melanoma PRR Ovarian\* Advanced endometrial 2L+ NSCLC IMC-P115C PRAME-A02-HLE Multiple solid tumors IMC-T119C PRAME-A24 Multiple solid tumors IMC-R117C PIWIL1 Colorectal, gastric, pancreatic IMC-C103C1 MAGE-A4 Multiple solid tumors IMC-I109V Envelope Hepatitis B Virus (HBV) IMC-M113V2 Gag Human Immunodeficiency Virus (HIV) New Im mTAC candidate 1. Developed under a co-development/co-promotion collaboration with Genentech; 2. Program is wholly owned, development costs being provided by the Bill & Melinda Gates Foundation (BMGF), Immunocore retains all development and commercialization rights in the developed world. \* Platinum refractory or resistant serous ovarian carcinoma

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![](brhc10046543_99-1slide28.jpg)

~$400M \*Preliminary financial results are approximated and unaudited. 1. "Net sales" refers to total net product and net pre-product revenue of KIMMTRAK and tebentafusp. 2. Dollar amounts based on conversion rate of approximately 1.21. 28 Q4 preliminary net sales of KIMMTRAK / tebentafusp1,2 Preliminary cash and cash equivalents as of December 31, 20222 YE preliminary net sales of KIMMTRAK / tebentafusp1,2 ~$50M ~$140M Preliminary 2022 Financial Results Cash runway projected into 2026 with anticipated KIMMTRAK revenues

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![](brhc10046543_99-1slide29.jpg)

41st Annual J.P. Morgan Healthcare Conference 29 Looking ahead Continuing to write the next chapter of cancer and infectious diseases treatment Sustain and grow Global site expansion for PRAME-A02 trial (data by 1H 2024) Deliver IND for 3 new ImmTAC candidates HIV Phase 1 SAD data 2023 Continue responsible management of resources

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![](brhc10046543_99-1slide30.jpg)

Experienced team with deep scientific & commercial expertise 30 Andy Hooker VP, CMC & Supply Chain JoAnn Suzich Head of Research Ralph Torbay Head of Commercial Mark Moyer Head of Regulatory CIMZIA SYNAGIS, FLUMIST, VLP technology for HPV vaccines YERVOY, OPDIVO, TAXOTERE, ZOLADEX, PLAVIX, JEVTANA, ELOXATIN IMFINZI, TAGRISSO, CALQUENCE, GLEEVEC, TASIGNA, ARZERRA, FARYDAK Bahija Jallal CEO Brian Di Donato CFO & Head of Strategy Mohammed Dar CMO David Berman Head of R&D YERVOY, EMPLICITI, LUMOXITI, IMFINZI VOTRIENT, IMFINZI, LUMOXITI IMFINZI, FASENRA, LUMOXITI, SELIQ, QAIV, SAPHNELO Regulatory approval of KIMMTRAK® in unresectable or metastatic uveal melanoma (mUM) in 30+ countries

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![](brhc10046543_99-1slide31.jpg)

THANK YOU

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![](brhc10046543_99-1slide32.jpg)

32 Delivering leading bispecific TCR pipeline Multiple candidates in oncology and infectious diseases O N C O L O G Y INFECTIOUS DISEASES Candidate Target Indication IND-enabling Phase 1 Phase 2 Phase 3 Approved gp100 Uveal melanoma Advanced melanoma Tebentafusp Multiple solid tumors Monotherapy dose explor ation Multiple solid tumors Combinations w/ standar ds of care IMC-F106C PRAME-A02 2L+ cutaneous melanoma PRR Ovarian\* Advanced endometrial 2L+ NSCLC IMC-P115C PRAME-A02-HLE Multiple solid tumors IMC-T119C PRAME-A24 Multiple solid tumors IMC-R117C PIWIL1 Colorectal, gastric, pancreatic IMC-C103C1 MAGE-A4 Multiple solid tumors IMC-I109V Envelope Hepatitis B Virus (HBV) IMC-M113V2 Gag Human Immunodeficiency Virus (HIV) New Im mTAC candidate 1. Developed under a co-development/co-promotion collaboration with Genentech; 2. Program is wholly owned, development costs being provided by the Bill & Melinda Gates Foundation (BMGF), Immunocore retains all development and commercialization rights in the developed world. \* Platinum refractory or resistant serous ovarian carcinoma

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