# EDGAR Filing Document

**Accession Number:** 0001697316
**File Stem:** 0001104659-25-063992
**Filing Date:** 2025-6
**Character Count:** 44282
**Document Hash:** 960ee488c6b09a1ef82b711ea6372e8d
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-25-063992.hdr.sgml**: 20250630

**ACCESSION NUMBER**: 0001104659-25-063992

**CONFORMED SUBMISSION TYPE**: 4

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20250627

**FILED AS OF DATE**: 20250630

**DATE AS OF CHANGE**: 20250630

**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** BIOS Fund II NT, LP
- **CENTRAL INDEX KEY:** 0001728851

**ORGANIZATION NAME:**
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-42139
- **FILM NUMBER:** 251090442

**BUSINESS ADDRESS:**
- **STREET 1:** 1401 FOCH STREET, SUITE 140
- **CITY:** FORT WORTH
- **STATE:** TX
- **ZIP:** 76107
- **BUSINESS PHONE:** 817-984-5964

**MAIL ADDRESS:**
- **STREET 1:** 1401 FOCH STREET, SUITE 140
- **CITY:** FORT WORTH
- **STATE:** TX
- **ZIP:** 76107
**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** BIOS Fund I, LP
- **CENTRAL INDEX KEY:** 0001697316

**ORGANIZATION NAME:**
- **STATE OF INCORPORATION:** TX
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-42139
- **FILM NUMBER:** 251090446

**BUSINESS ADDRESS:**
- **STREET 1:** 1401 FOCH STREET
- **STREET 2:** SUITE 140
- **CITY:** FORT WORTH
- **STATE:** TX
- **ZIP:** 76107
- **BUSINESS PHONE:** 817-984-5964

**MAIL ADDRESS:**
- **STREET 1:** 1401 FOCH STREET
- **STREET 2:** SUITE 140
- **CITY:** FORT WORTH
- **STATE:** TX
- **ZIP:** 76107
**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** BIOS Fund I QP, LP
- **CENTRAL INDEX KEY:** 0001700297

**ORGANIZATION NAME:**
- **STATE OF INCORPORATION:** TX
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-42139
- **FILM NUMBER:** 251090445

**BUSINESS ADDRESS:**
- **STREET 1:** 1401 FOCH STREET, SUITE 140
- **CITY:** FORT WORTH
- **STATE:** TX
- **ZIP:** 76107
- **BUSINESS PHONE:** 817-984-5964

**MAIL ADDRESS:**
- **STREET 1:** 1401 FOCH STREET, SUITE 140
- **CITY:** FORT WORTH
- **STATE:** TX
- **ZIP:** 76107
**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** BIOS Fund II, LP
- **CENTRAL INDEX KEY:** 0001714576

**ORGANIZATION NAME:**
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-42139
- **FILM NUMBER:** 251090443

**BUSINESS ADDRESS:**
- **STREET 1:** 1401 FOCH STREET
- **STREET 2:** SUITE 140
- **CITY:** FORT WORTH
- **STATE:** TX
- **ZIP:** 76107
- **BUSINESS PHONE:** 817-984-5964

**MAIL ADDRESS:**
- **STREET 1:** 1401 FOCH STREET
- **STREET 2:** SUITE 140
- **CITY:** FORT WORTH
- **STATE:** TX
- **ZIP:** 76107
**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** BIOS Fund II QP, LP
- **CENTRAL INDEX KEY:** 0001716869

**ORGANIZATION NAME:**
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-42139
- **FILM NUMBER:** 251090441

**BUSINESS ADDRESS:**
- **STREET 1:** 1401 FOCH STREET
- **STREET 2:** SUITE 140
- **CITY:** FORT WORTH
- **STATE:** TX
- **ZIP:** 76107
- **BUSINESS PHONE:** 817-984-5964

**MAIL ADDRESS:**
- **STREET 1:** 1401 FOCH STREET
- **STREET 2:** SUITE 140
- **CITY:** FORT WORTH
- **STATE:** TX
- **ZIP:** 76107
**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Kreis Leslie W.
- **CENTRAL INDEX KEY:** 0001813316

**ORGANIZATION NAME:**

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-42139
- **FILM NUMBER:** 251090449

**MAIL ADDRESS:**
- **STREET 1:** 1751 RIVER RUN, SUITE 400
- **CITY:** FORT WORTH
- **STATE:** TX
- **ZIP:** 76107
**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Cavu Management, LP
- **CENTRAL INDEX KEY:** 0001813270

**ORGANIZATION NAME:**
- **STATE OF INCORPORATION:** TX
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-42139
- **FILM NUMBER:** 251090447

**BUSINESS ADDRESS:**
- **STREET 1:** 1751 RIVER RUN, SUITE 400
- **CITY:** FORT WORTH
- **STATE:** TX
- **ZIP:** 76107
- **BUSINESS PHONE:** 817-381-5370

**MAIL ADDRESS:**
- **STREET 1:** 1751 RIVER RUN, SUITE 400
- **CITY:** FORT WORTH
- **STATE:** TX
- **ZIP:** 76107
**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Cavu Advisors, LLC
- **CENTRAL INDEX KEY:** 0001813310

**ORGANIZATION NAME:**
- **STATE OF INCORPORATION:** TX
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-42139
- **FILM NUMBER:** 251090448

**BUSINESS ADDRESS:**
- **STREET 1:** 1751 RIVER RUN, SUITE 400
- **CITY:** FORT WORTH
- **STATE:** TX
- **ZIP:** 76107
- **BUSINESS PHONE:** 817-381-5370

**MAIL ADDRESS:**
- **STREET 1:** 1751 RIVER RUN, SUITE 400
- **CITY:** FORT WORTH
- **STATE:** TX
- **ZIP:** 76107
**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Bios Equity Partners II, LP
- **CENTRAL INDEX KEY:** 0001813313

**ORGANIZATION NAME:**
- **STATE OF INCORPORATION:** TX
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-42139
- **FILM NUMBER:** 251090440

**BUSINESS ADDRESS:**
- **STREET 1:** 1751 RIVER RUN, SUITE 400
- **CITY:** FORT WORTH
- **STATE:** TX
- **ZIP:** 76107
- **BUSINESS PHONE:** 817-381-5370

**MAIL ADDRESS:**
- **STREET 1:** 1751 RIVER RUN, SUITE 400
- **CITY:** FORT WORTH
- **STATE:** TX
- **ZIP:** 76107
**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Bios Equity Partners, LP
- **CENTRAL INDEX KEY:** 0001813314

**ORGANIZATION NAME:**
- **STATE OF INCORPORATION:** TX
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 4
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-42139
- **FILM NUMBER:** 251090444

**BUSINESS ADDRESS:**
- **STREET 1:** 1751 RIVER RUN, SUITE 400
- **CITY:** FORT WORTH
- **STATE:** TX
- **ZIP:** 76107
- **BUSINESS PHONE:** 817-381-5370

**MAIL ADDRESS:**
- **STREET 1:** 1751 RIVER RUN, SUITE 400
- **CITY:** FORT WORTH
- **STATE:** TX
- **ZIP:** 76107
**ISSUER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** ACTUATE THERAPEUTICS, INC.
- **CENTRAL INDEX KEY:** 0001652935
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 473044785
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**BUSINESS ADDRESS:**
- **STREET 1:** 1751 RIVER RUN
- **STREET 2:** SUITE 400
- **CITY:** FORT WORTH
- **STATE:** TX
- **ZIP:** 76107
- **BUSINESS PHONE:** 847-986-4190

**MAIL ADDRESS:**
- **STREET 1:** 1751 RIVER RUN
- **STREET 2:** SUITE 400
- **CITY:** FORT WORTH
- **STATE:** TX
- **ZIP:** 76107

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Apotheca Therapeutics, Inc.
- **DATE OF NAME CHANGE:** 20150911

## Ex-24

**Exhibit 24**

**POWER OF ATTORNEY**

The undersigned hereby removes the following authority from Daniel Schwarz and, in his place, constitutes and appoints John Fucci and Troy Osborn, the lawful attorneys-in-fact and agents with full power and authority to execute and file on the undersigned's behalf, any and all instruments including Forms 3, 4 and 5, and Schedules 13D, 13G and 13F (collectively, the "Filings"), and any amendments, supplements or successor forms thereto pursuant to the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and any rules or regulations or requirements of the Securities and Exchange Commission in connection with the undersigned's reporting obligations with respect to securities of Actuate Therapeutics, Inc., a Delaware corporation, pursuant to Section 13 of the Exchange Act and Section 16 of the Exchange Act.

The authority of such attorneys-in-fact shall continue until the undersigned is no longer required to file any of the Filings, unless earlier revoked in writing. The undersigned hereby ratifies, confirms and approves in all respects all Filings (including amendments thereto) and actions taken by any of the attorneys-in-fact relating to such Filings.

The undersigned acknowledges that the attorneys-in-fact are not assuming any of the undersigned's responsibilities to comply with Section 13 or Section 16 of the Exchange Act.

IN WITNESS WHEREOF, each of the undersigned has executed this Power of Attorney as of the date indicated.

Dated: May 22, 2025

---

| | | |
|:---|:---|:---|
| **BIOS FUND I, LP** | **BIOS FUND I, LP** | **BIOS FUND I, LP** |
| By: | Bios Equity Partners, LP, | Bios Equity Partners, LP, |
|  | its general partner | its general partner |
|  | Cavu Management, LP, | Cavu Management, LP, |
|  | its general partner | its general partner |
|  | Cavu Advisors, LLC, | Cavu Advisors, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Leslie Wayne Kreis, Jr.* |
|  |  | Leslie Wayne Kreis, Jr. |
|  |  | Manager |
|  | Bios Capital Management, LP, | Bios Capital Management, LP, |
|  | its general partner | its general partner |
|  | Bios Advisors GP, LLC, | Bios Advisors GP, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Aaron Glenn Louis Fletcher* |
|  |  | Aaron Glenn Louis Fletcher |
|  |  | Manager |

---

---

| | | |
|:---|:---|:---|
| **BIOS FUND I QP, LP** | **BIOS FUND I QP, LP** | **BIOS FUND I QP, LP** |
| By: | Bios Equity Partners, LP, | Bios Equity Partners, LP, |
|  | its general partner | its general partner |
|  | Cavu Management, LP, | Cavu Management, LP, |
|  | its general partner | its general partner |
|  | Cavu Advisors, LLC, | Cavu Advisors, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Leslie Wayne Kreis, Jr.* |
|  |  | Leslie Wayne Kreis, Jr. |
|  |  | Manager |
|  | Bios Capital Management, LP, | Bios Capital Management, LP, |
|  | its general partner | its general partner |
|  | Bios Advisors GP, LLC, | Bios Advisors GP, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Aaron Glenn Louis Fletcher* |
|  |  | Aaron Glenn Louis Fletcher |
|  |  | Manager |

---

---

| | | |
|:---|:---|:---|
| **BP DIRECTORS, LP** | **BP DIRECTORS, LP** | **BP DIRECTORS, LP** |
| By: | Bios Equity Partners, LP, | Bios Equity Partners, LP, |
|  | its general partner | its general partner |
|  | Cavu Management, LP, | Cavu Management, LP, |
|  | its general partner | its general partner |
|  | Cavu Advisors, LLC, | Cavu Advisors, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Leslie Wayne Kreis, Jr.* |
|  |  | Leslie Wayne Kreis, Jr., |
|  |  | Manager |
|  | Bios Capital Management, LP, | Bios Capital Management, LP, |
|  | its general partner | its general partner |
|  | Bios Advisors GP, LLC, | Bios Advisors GP, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Aaron Glenn Louis Fletcher* |
|  |  | Aaron Glenn Louis Fletcher, |
|  |  | Manager |

---

---

| | | |
|:---|:---|:---|
| **BIOS FUND II, LP** | **BIOS FUND II, LP** | **BIOS FUND II, LP** |
| By: | Bios Equity Partners II, LP, | Bios Equity Partners II, LP, |
|  | its general partner | its general partner |
|  | Cavu Management, LP, | Cavu Management, LP, |
|  | its general partner | its general partner |
|  | Cavu Advisors, LLC, | Cavu Advisors, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Leslie Wayne Kreis, Jr.* |
|  |  | Leslie Wayne Kreis, Jr. |
|  |  | Manager |
|  | Bios Capital Management, LP, | Bios Capital Management, LP, |
|  | its general partner | its general partner |
|  | Bios Advisors GP, LLC, | Bios Advisors GP, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Aaron Glenn Louis Fletcher* |
|  |  | Aaron Glenn Louis Fletcher |
|  |  | Manager |

---

---

| | | |
|:---|:---|:---|
| **BIOS FUND II QP, LP** | **BIOS FUND II QP, LP** | **BIOS FUND II QP, LP** |
| By: | Bios Equity Partners II, LP, | Bios Equity Partners II, LP, |
|  | its general partner | its general partner |
|  | Cavu Management, LP, | Cavu Management, LP, |
|  | its general partner | its general partner |
|  | Cavu Advisors, LLC, | Cavu Advisors, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Leslie Wayne Kreis, Jr.* |
|  |  | Leslie Wayne Kreis, Jr., |
|  |  | Manager |
|  | Bios Capital Management, LP, | Bios Capital Management, LP, |
|  | its general partner | its general partner |
|  | Bios Advisors GP, LLC, | Bios Advisors GP, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Aaron Glenn Louis Fletcher* |
|  |  | Aaron Glenn Louis Fletcher, |
|  |  | Manager |

---

---

| | | |
|:---|:---|:---|
| **BIOS FUND II NT, LP** | **BIOS FUND II NT, LP** | **BIOS FUND II NT, LP** |
| By: | Bios Equity Partners II, LP, | Bios Equity Partners II, LP, |
|  | its general partner | its general partner |
|  | Cavu Management, LP, | Cavu Management, LP, |
|  | its general partner | its general partner |
|  | Cavu Advisors, LLC, | Cavu Advisors, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Leslie Wayne Kreis, Jr.* |
|  |  | Leslie Wayne Kreis, Jr., |
|  |  | Manager |
|  | Bios Capital Management, LP, | Bios Capital Management, LP, |
|  | its general partner | its general partner |
|  | Bios Advisors GP, LLC, | Bios Advisors GP, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Aaron Glenn Louis Fletcher* |
|  |  | Aaron Glenn Louis Fletcher, |
|  |  | Manager |

---

---

| | | |
|:---|:---|:---|
| **BIOS ACTUATE CO-INVEST I, LP** | **BIOS ACTUATE CO-INVEST I, LP** | **BIOS ACTUATE CO-INVEST I, LP** |
| By: | Bios Equity Partners II, LP, | Bios Equity Partners II, LP, |
|  | its general partner | its general partner |
|  | Cavu Management, LP, | Cavu Management, LP, |
|  | its general partner | its general partner |
|  | Cavu Advisors, LLC, | Cavu Advisors, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Leslie Wayne Kreis, Jr.* |
|  |  | Leslie Wayne Kreis, Jr., |
|  |  | Manager |
|  | Bios Capital Management, LP, | Bios Capital Management, LP, |
|  | its general partner | its general partner |
|  | Bios Advisors GP, LLC, | Bios Advisors GP, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Aaron Glenn Louis Fletcher* |
|  |  | Aaron Glenn Louis Fletcher, |
|  |  | Manager |

---

---

| | | |
|:---|:---|:---|
| **BIOS FUND III, LP** | **BIOS FUND III, LP** | **BIOS FUND III, LP** |
| By: | Bios Equity Partners III, LP, | Bios Equity Partners III, LP, |
|  | its general partner | its general partner |
|  | Cavu Management, LP, | Cavu Management, LP, |
|  | its general partner | its general partner |
|  | Cavu Advisors, LLC, | Cavu Advisors, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Leslie Wayne Kreis, Jr.* |
|  |  | Leslie Wayne Kreis, Jr., |
|  |  | Manager |
|  | Bios Capital Management, LP, | Bios Capital Management, LP, |
|  | its general partner | its general partner |
|  | Bios Advisors GP, LLC, | Bios Advisors GP, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Aaron Glenn Louis Fletcher* |
|  |  | Aaron Glenn Louis Fletcher, |
|  |  | Manager |

---

---

| | | |
|:---|:---|:---|
| **BIOS FUND III QP, LP** | **BIOS FUND III QP, LP** | **BIOS FUND III QP, LP** |
| By: | Bios Equity Partners III, LP, | Bios Equity Partners III, LP, |
|  | its general partner | its general partner |
|  | Cavu Management, LP, | Cavu Management, LP, |
|  | its general partner | its general partner |
|  | Cavu Advisors, LLC, | Cavu Advisors, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Leslie Wayne Kreis, Jr.* |
|  |  | Leslie Wayne Kreis, Jr., |
|  |  | Manager |
|  | Bios Capital Management, LP, | Bios Capital Management, LP, |
|  | its general partner | its general partner |
|  | Bios Advisors GP, LLC, | Bios Advisors GP, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Aaron Glenn Louis Fletcher* |
|  |  | Aaron Glenn Louis Fletcher, |
|  |  | Manager |

---

---

| | | |
|:---|:---|:---|
| **BIOS FUND III NT, LP** | **BIOS FUND III NT, LP** | **BIOS FUND III NT, LP** |
| By: | Bios Equity Partners III, LP, | Bios Equity Partners III, LP, |
|  | its general partner | its general partner |
|  | Cavu Management, LP, | Cavu Management, LP, |
|  | its general partner | its general partner |
|  | Cavu Advisors, LLC, | Cavu Advisors, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Leslie Wayne Kreis, Jr.* |
|  |  | Leslie Wayne Kreis, Jr., |
|  |  | Manager |
|  | Bios Capital Management, LP, | Bios Capital Management, LP, |
|  | its general partner | its general partner |
|  | Bios Advisors GP, LLC, | Bios Advisors GP, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Aaron Glenn Louis Fletcher* |
|  |  | Aaron Glenn Louis Fletcher, |
|  |  | Manager |

---

---

| | | |
|:---|:---|:---|
| **BIOS ACTUATE CO-INVEST II, LP** | **BIOS ACTUATE CO-INVEST II, LP** | **BIOS ACTUATE CO-INVEST II, LP** |
| By: | Bios Equity Partners III, LP, | Bios Equity Partners III, LP, |
|  | its general partner | its general partner |
|  | Cavu Management, LP, | Cavu Management, LP, |
|  | its general partner | its general partner |
|  | Cavu Advisors, LLC, | Cavu Advisors, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Leslie Wayne Kreis, Jr.* |
|  |  | Leslie Wayne Kreis, Jr., |
|  |  | Manager |
|  | Bios Capital Management, LP, | Bios Capital Management, LP, |
|  | its general partner | its general partner |
|  | Bios Advisors GP, LLC, | Bios Advisors GP, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Aaron Glenn Louis Fletcher* |
|  |  | Aaron Glenn Louis Fletcher, |
|  |  | Manager |

---

---

| | | |
|:---|:---|:---|
| **BIOS ACTUATE CO-INVEST III, LP** | **BIOS ACTUATE CO-INVEST III, LP** | **BIOS ACTUATE CO-INVEST III, LP** |
| By: | Bios Equity Partners III, LP, | Bios Equity Partners III, LP, |
|  | its general partner | its general partner |
|  | Cavu Management, LP, | Cavu Management, LP, |
|  | its general partner | its general partner |
|  | Cavu Advisors, LLC, | Cavu Advisors, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Leslie Wayne Kreis, Jr.* |
|  |  | Leslie Wayne Kreis, Jr., |
|  |  | Manager |
|  | Bios Capital Management, LP, | Bios Capital Management, LP, |
|  | its general partner | its general partner |
|  | Bios Advisors GP, LLC, | Bios Advisors GP, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Aaron Glenn Louis Fletcher* |
|  |  | Aaron Glenn Louis Fletcher, |
|  |  | Manager |

---

---

| | | |
|:---|:---|:---|
| **BIOS CLINICAL OPPORTUNITY FUND, LP** | **BIOS CLINICAL OPPORTUNITY FUND, LP** | **BIOS CLINICAL OPPORTUNITY FUND, LP** |
| By: | Bios Equity COF, LP, | Bios Equity COF, LP, |
|  | its general partner | its general partner |
|  | Bios Capital Management, LP, | Bios Capital Management, LP, |
|  | its general partner | its general partner |
|  | Bios Advisors GP, LLC, | Bios Advisors GP, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Aaron Glenn Louis Fletcher* |
|  |  | Aaron Glenn Louis Fletcher, |
|  |  | Manager |
| **BIOS 2024 CO-INVEST, LP** | **BIOS 2024 CO-INVEST, LP** | **BIOS 2024 CO-INVEST, LP** |
| By: | Bios Equity COF, LP, | Bios Equity COF, LP, |
|  | its general partner | its general partner |
|  | Bios Capital Management, LP, | Bios Capital Management, LP, |
|  | its general partner | its general partner |
|  | Bios Advisors GP, LLC, | Bios Advisors GP, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Aaron Glenn Louis Fletcher* |
|  |  | Aaron Glenn Louis Fletcher, |
|  |  | Manager |

---

---

| | | |
|:---|:---|:---|
| **BIOS EQUITY PARTNERS, LP** | **BIOS EQUITY PARTNERS, LP** | **BIOS EQUITY PARTNERS, LP** |
| By: | Cavu Management, LP, | Cavu Management, LP, |
|  | its general partner | its general partner |
|  | Cavu Advisors, LLC, | Cavu Advisors, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Leslie Wayne Kreis, Jr.* |
|  |  | Leslie Wayne Kreis, Jr., |
|  |  | Manager |
| By: | Bios Capital Management, LP, | Bios Capital Management, LP, |
|  | its general partner | its general partner |
|  | Bios Advisors GP, LLC, | Bios Advisors GP, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Aaron Glenn Louis Fletcher* |
|  |  | Aaron Glenn Louis Fletcher, |
|  |  | Manager |

---

---

| | | |
|:---|:---|:---|
| **BIOS EQUITY PARTNERS II, LP** | **BIOS EQUITY PARTNERS II, LP** | **BIOS EQUITY PARTNERS II, LP** |
| By: | Cavu Management, LP, | Cavu Management, LP, |
|  | its general partner | its general partner |
|  | Cavu Advisors, LLC, | Cavu Advisors, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Leslie Wayne Kreis, Jr.* |
|  |  | Leslie Wayne Kreis, Jr., |
|  |  | Manager |
| By: | Bios Capital Management, LP, | Bios Capital Management, LP, |
|  | its general partner | its general partner |
|  | Bios Advisors GP, LLC, | Bios Advisors GP, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Aaron Glenn Louis Fletcher* |
|  |  | Aaron Glenn Louis Fletcher, |
|  |  | Manager |

---

---

| | | |
|:---|:---|:---|
| **BIOS EQUITY PARTNERS III, LP** | **BIOS EQUITY PARTNERS III, LP** | **BIOS EQUITY PARTNERS III, LP** |
| By: | Cavu Management, LP, | Cavu Management, LP, |
|  | its general partner | its general partner |
|  | Cavu Advisors, LLC, | Cavu Advisors, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Leslie Wayne Kreis, Jr.* |
|  |  | Leslie Wayne Kreis, Jr., |
|  |  | Manager |
| By: | Bios Capital Management, LP, | Bios Capital Management, LP, |
|  | its general partner | its general partner |
|  | Bios Advisors GP, LLC, | Bios Advisors GP, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Aaron Glenn Louis Fletcher* |
|  |  | Aaron Glenn Louis Fletcher, |
|  |  | Manager |

---

---

| | | |
|:---|:---|:---|
| **BIOS EQUITY COF, LP** | **BIOS EQUITY COF, LP** | **BIOS EQUITY COF, LP** |
| By: | Bios Capital Management, LP, | Bios Capital Management, LP, |
|  | its general partner | its general partner |
|  | Bios Advisors GP, LLC, | Bios Advisors GP, LLC, |
|  | its general partner | its general partner |
|  | By: | */s/ Aaron Glenn Louis Fletcher* |
|  |  | Aaron Glenn Louis Fletcher, |
|  |  | Manager |
| **CAVU MANAGEMENT, LP** | **CAVU MANAGEMENT, LP** | **CAVU MANAGEMENT, LP** |
| By: | Cavu Advisors, LLC, | Cavu Advisors, LLC, |
|  | its general partner | its general partner |
|  | */s/ Leslie Wayne Kreis, Jr.* | */s/ Leslie Wayne Kreis, Jr.* |
|  | Leslie Wayne Kreis, Jr., | Leslie Wayne Kreis, Jr., |
|  | Manager | Manager |

---

---

| | | |
|:---|:---|:---|
| **BIOS CAPITAL MANAGEMENT, LP** | **BIOS CAPITAL MANAGEMENT, LP** | **BIOS CAPITAL MANAGEMENT, LP** |
| By: | Bios Advisors GP, LLC | Bios Advisors GP, LLC |
|  | its general partner | its general partner |
|  | By: | */s/ Aaron Glenn Louis Fletcher* |
|  |  | Aaron Glenn Louis Fletcher |
|  |  | Manager |

---

---

| | |
|:---|:---|
| **CAVU ADVISORS, LLC** | **CAVU ADVISORS, LLC** |
| By: | */s/ Leslie Wayne Kreis, Jr.* |
|  | Leslie Wayne Kreis, Jr., |
|  | Manager |

---

---

| | |
|:---|:---|
| **BIOS ADVISORS GP, LLC** | **BIOS ADVISORS GP, LLC** |
| By: | */s/ Aaron Glenn Louis Fletcher* |
|  | Aaron Glenn Louis Fletcher, |
|  | Manager |
| */s/ Leslie Wayne Kreis, Jr.* | */s/ Leslie Wayne Kreis, Jr.* |
| **LESLIE WAYNE KREIS, JR.,** in his individual capacity | **LESLIE WAYNE KREIS, JR.,** in his individual capacity |
| */s/ Aaron Glenn Louis Fletcher* | */s/ Aaron Glenn Louis Fletcher* |
| **AARON GLENN LOUIS FLETCHER,** in his individual capacity | **AARON GLENN LOUIS FLETCHER,** in his individual capacity |

---

### UNITED STATES SECURITIES AND EXCHANGE COMMISSION
**Washington, D.C. 20549**

## FORM 4

### STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

[ ] Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Kreis Leslie W.<br><sub>(Last) (First) (Middle)</sub><br>C/O BIOS EQUITY PARTNERS<br>1751 RIVER RUN SUITE 400<br><sub>(Street)</sub><br>FORT WORTH, TX 76107<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2025-06-27 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[X] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>ACTUATE THERAPEUTICS, INC. [ ACTU ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Cavu Advisors, LLC<br><sub>(Last) (First) (Middle)</sub><br>C/O BIOS EQUITY PARTNERS<br>1751 RIVER RUN SUITE 400<br><sub>(Street)</sub><br>FORT WORTH, TX 76107<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2025-06-27 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[X] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>ACTUATE THERAPEUTICS, INC. [ ACTU ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Cavu Management, LP<br><sub>(Last) (First) (Middle)</sub><br>C/O BIOS EQUITY PARTNERS<br>1751 RIVER RUN SUITE 400<br><sub>(Street)</sub><br>FORT WORTH, TX 76107<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2025-06-27 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[X] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>ACTUATE THERAPEUTICS, INC. [ ACTU ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>BIOS Fund I, LP<br><sub>(Last) (First) (Middle)</sub><br>C/O BIOS EQUITY PARTNERS<br>1751 RIVER RUN SUITE 400<br><sub>(Street)</sub><br>FORT WORTH, TX 76107<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2025-06-27 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[X] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>ACTUATE THERAPEUTICS, INC. [ ACTU ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>BIOS Fund I QP, LP<br><sub>(Last) (First) (Middle)</sub><br>C/O BIOS EQUITY PARTNERS<br>1751 RIVER RUN SUITE 400<br><sub>(Street)</sub><br>FORT WORTH, TX 76107<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2025-06-27 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[X] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>ACTUATE THERAPEUTICS, INC. [ ACTU ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Bios Equity Partners, LP<br><sub>(Last) (First) (Middle)</sub><br>C/O BIOS EQUITY PARTNERS<br>1751 RIVER RUN SUITE 400<br><sub>(Street)</sub><br>FORT WORTH, TX 76107<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2025-06-27 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[X] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>ACTUATE THERAPEUTICS, INC. [ ACTU ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>BIOS Fund II, LP<br><sub>(Last) (First) (Middle)</sub><br>C/O BIOS EQUITY PARTNERS<br>1751 RIVER RUN SUITE 400<br><sub>(Street)</sub><br>FORT WORTH, TX 76107<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2025-06-27 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[X] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>ACTUATE THERAPEUTICS, INC. [ ACTU ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>BIOS Fund II NT, LP<br><sub>(Last) (First) (Middle)</sub><br>C/O BIOS EQUITY PARTNERS<br>1751 RIVER RUN SUITE 400<br><sub>(Street)</sub><br>FORT WORTH, TX 76107<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2025-06-27 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[X] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>ACTUATE THERAPEUTICS, INC. [ ACTU ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>BIOS Fund II QP, LP<br><sub>(Last) (First) (Middle)</sub><br>C/O BIOS EQUITY PARTNERS<br>1751 RIVER RUN SUITE 400<br><sub>(Street)</sub><br>FORT WORTH, TX 76107<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2025-06-27 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[X] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>ACTUATE THERAPEUTICS, INC. [ ACTU ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Bios Equity Partners II, LP<br><sub>(Last) (First) (Middle)</sub><br>C/O BIOS EQUITY PARTNERS<br>1751 RIVER RUN SUITE 400<br><sub>(Street)</sub><br>FORT WORTH, TX 76107<br><sub>(City) (State) (Zip)</sub> | **3. Date of Earliest Transaction (Month/Day/Year)**<br>2025-06-27 | **5. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[X] Director [X] 10% Owner<br>[ ] Officer (give title below) [ ] Other (specify below)<br>_ _ |
| **2. Issuer Name and Ticker or Trading Symbol**<br>ACTUATE THERAPEUTICS, INC. [ ACTU ] | **4. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[ ] Form filed by One Reporting Person<br>[X] Form filed by More than One Reporting Person |

---

## Table I - Non-Derivative Securities

---

|  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1. Title of Security | 2. Transaction Date | 2A. Deemed Execution Date | 3. Transaction Code (V) | 3. Transaction Code (V) | 4. Securities Acquired (A) or Disposed of (D) | 4. Securities Acquired (A) or Disposed of (D) | 4. Securities Acquired (A) or Disposed of (D) | 5. Amount of Securities Beneficially Owned | 6. Ownership Form | 7. Nature of Indirect Beneficial Ownership |
| 1. Title of Security | 2. Transaction Date | 2A. Deemed Execution Date | Code | V | Amount | (A) or (D) | Price | 5. Amount of Securities Beneficially Owned | 6. Ownership Form | 7. Nature of Indirect Beneficial Ownership |
| Common Stock | 2025-06-27 |  | P<sup>(1)</sup> |  | 71428 | A | $7 | 196428 | I | Directly held by Bios 2024 Co-Invest, LP<sup>(3)(4)(5)</sup> |
| Common Stock |  |  |  |  |  |  |  | 1259427 | I | Directly held by Bios Clinical Opportunity Fund, LP<sup>(3)(4)(5)</sup> |
| Common Stock |  |  |  |  |  |  |  | 525797 | I | Directly held by Bios Fund I, LP<sup>(3)(4)(5)</sup> |
| Common Stock |  |  |  |  |  |  |  | 307538 | I | Directly held by Bios Fund I QP, LP<sup>(3)(4)(5)</sup> |
| Common Stock |  |  |  |  |  |  |  | 300143 | I | Directly held by Bios Fund II, LP<sup>(3)(4)(5)</sup> |
| Common Stock |  |  |  |  |  |  |  | 980433 | I | Directly held by Bios Fund II QP, LP<sup>(3)(4)(5)</sup> |
| Common Stock |  |  |  |  |  |  |  | 131248 | I | Directly held by Bios Fund II NT, LP<sup>(3)(4)(5)</sup> |
| Common Stock |  |  |  |  |  |  |  | 300749 | I | Directly held by Bios Actuate Co-Invest I, LP<sup>(3)(4)(5)</sup> |
| Common Stock |  |  |  |  |  |  |  | 383791 | I | Directly held by Bios Fund III, LP<sup>(3)(4)(5)</sup> |
| Common Stock |  |  |  |  |  |  |  | 2506667 | I | Directly held by Bios Fund III QP, LP<sup>(3)(4)(5)</sup> |
| Common Stock |  |  |  |  |  |  |  | 404814 | I | Directly held by Bios Fund III NT, LP<sup>(3)(4)(5)</sup> |
| Common Stock |  |  |  |  |  |  |  | 2094650 | I | Directly held by Bios Actuate Co-Invest II, LP<sup>(3)(4)(5)</sup> |
| Common Stock |  |  |  |  |  |  |  | 573394 | I | Directly held by Bios Actuate Co-Invest III, LP<sup>(3)(4)(5)</sup> |
| Common Stock |  |  |  |  |  |  |  | 84917 | I | Directly held by BP Directors, LP<sup>(3)(4)(5)</sup> |
| Common Stock |  |  |  |  |  |  |  | 60973 | I | Directly held by Aaron G.L. Fletcher |
| Common Stock |  |  |  |  |  |  |  | 8056 | I | Directly held by KF Legacy Trust U/A/D December 7, 2016<sup>(6)</sup> |
| Common Stock |  |  |  |  |  |  |  | 8056 | I | Directly held by MF Legacy Trust U/A/D December 7, 2016<sup>(6)</sup> |
| Common Stock |  |  |  |  |  |  |  | 69375 | I | Directly held by Circle K Invesco, LP<sup>(7)</sup> |

---

## Table II - Derivative Securities

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| 1. Title of Derivative Security | 2. Conversion or Exercise Price | 3. Transaction Date | 3A. Deemed Execution Date | 4. Transaction Code (V) | 4. Transaction Code (V) | 5. Number of Derivative Securities Acquired (A) or Disposed of (D) | 5. Number of Derivative Securities Acquired (A) or Disposed of (D) | 6. Date Exercisable and Expiration Date | 6. Date Exercisable and Expiration Date | 7. Title and Amount of Underlying Securities | 7. Title and Amount of Underlying Securities | 8. Price of Derivative Security | 9. Number of Derivative Securities Beneficially Owned | 10. Ownership Form | 11. Nature of Indirect Beneficial Ownership |
| 1. Title of Derivative Security | 2. Conversion or Exercise Price | 3. Transaction Date | 3A. Deemed Execution Date | Code | V | (A) | (D) | Date Exercisable | Expiration Date | Title | Amount or Number of Shares | 8. Price of Derivative Security | 9. Number of Derivative Securities Beneficially Owned | 10. Ownership Form | 11. Nature of Indirect Beneficial Ownership |
| Warrant (Right to Buy) | $7 | 2025-06-27 |  | P<sup>(2)</sup> |  | 71428 |  | <sup>(2)</sup> | <sup>(2)</sup> | Common Stock | 71428 | $0 | 71428 | I | Directly held by Bios 2024 Co-Invest, LP<sup>(3)(4)(5)</sup> |

---

### Footnotes:

(1) Pursuant to a Securities Purchase Agreement (the "Securities Purchase Agreement"), dated as of June 25, 2025, between Actuate Therapeutics, Inc. (the "Issuer") and certain institutional and accredited investors, Bios 2024 Co-Invest, LP ("Bios 2024 Co-Invest") purchased from the Issuer in a private placement 71,428 shares of common stock, par value $001 per share (the "Common Stock"), and warrants to purchase 71,428 shares of Common Stock (the "Warrants"). The closing of the transactions contemplated by the Securities Purchase Agreement occurred on June 27, 2025.

(2) The Warrants are exercisable on a cash only basis at any time after the date of issuance and expire 20 days following the earliest to occur of (i) the U.S. Food and Drug Administration ("FDA") issuing Breakthrough Therapy designation for elraglusib and (ii) the date that the FDA provides written communication available to the Issuer of its determination as to whether the Issuer may pursue registration for elraglusib using Phase 2 or Phase 3 clinical data.

(3) Bios Equity Partners, LP ("Bios Equity I") is the general partner of the following entities: Bios Fund I, LP ("Bios Fund I"), Bios Fund I QP, LP ("Bios Fund I QP") and BP Directors, LP ("BP Directors"). Bios Equity Partners II, LP ("Bios Equity II") is the general partner of Bios Fund II, LP ("Bios Fund II"), Bios Fund II QP, LP ("Bios Fund II QP"), Bios Fund II NT, LP ("Bios Fund II NT") and Bios Actuate Co-Invest I, LP ("Bios Actuate Co-Invest I"). Bios Equity Partners III, LP ("Bios Equity III") is the general partner of the following entities: Bios Fund III, LP ("Bios Fund III"), Bios Fund III QP, LP ("Bios Fund III QP"), Bios Fund III NT, LP ("Bios Fund III NT"), Bios Actuate Co-Invest II, LP ("Bios Actuate Co-Invest II") and Bios Actuate Co-Invest III, LP ("Bios Actuate Co-Invest III"). Bios Equity COF, LP ("Bios Equity COF") is the general partner of Bios Clinical Opportunity Fund, LP ("Bios COF") and Bios 2024 Co-Invest.

(4) (Footnote 3 Continue) Cavu Management, LP, an entity managed and controlled by Mr. Les Kreis, and Bios Capital Management, LP, an entity managed and controlled by Mr. Aaron Fletcher, are the general partners of Bios Equity I, Bios Equity II and Bios Equity III and Bios Capital Management, LP is the general partner of Bios Equity COF. Cavu Advisors LLC, an entity that is managed and controlled by Mr. Kreis, is the general partner of Cavu Management LP. Bios Advisors GP, LLC, an entity that is managed and controlled by Mr. Fletcher, is the general partner of Bios Capital Management, LP.

(5) (Footnote 3 Continue)The shares owned by Bios Fund I, Bios Fund I QP, BP Directors, Bios Fund II, Bios Fund II QP, Bios Fund II NT, Bios Actuate Co-Invest I, Bios Fund III, Bios Fund III QP, Bios Fund III NT, Bios Actuate Co-Invest II, Bios Actuate Co-Invest III, Bios COF and Bios 2024 Co-Invest (collectively, the "Bios Equity Entities") are aggregated for purposes of reporting share ownership information. Mr. Kreis and Mr. Fletcher have voting and investment control with respect to shares held indirectly by Bios Advisors GP, LLC and Cavu Advisors, LLC, respectively.

(6) Shares are held in a trust, which has an independent trustee, for the benefit of Mr. Fletcher's children. Mr. Fletcher disclaims beneficial ownership of such shares other than to the extent he may have a pecuniary interest therein.

(7) Shares are held by Circle K Invesco, LP, over which Mr. Kreis has sole voting and investment control.

**Remarks:**
Exhibit 24 - Power of Attorney
Each of the reporting persons may be deemed a "director by deputization" as the result of Aaron G.L. Fletcher's position as a director of the Issuer.
This Form 4 is the second of three Forms 4 filed relating to the same event. The Form 4 has been split into three filings because there are more than 10 reporting persons in total, and the SEC's EDGAR filing system limits a single Form 4 to a maximum of 10 reporting persons. The first Form 4 was filed by Aaron G.L. Fletcher as the designated filer. The third Form 4 will be filed by Bios Equity COF, LP as the designated filer.

**Signature:** Leslie W. Kreis, Jr By: /s/ John Fucci, as attorney-in-fact  
**Date:** 2025-06-30

**Signature:** Cavu Advisors, LLC By: /s/ John Fucci, as attorney-in-fact  
**Date:** 2025-06-30

**Signature:** Cavu Management, LP By: Cavu Advisors, LLC, its general partner By: /s/ John Fucci, as attorney-in-fact  
**Date:** 2025-06-30

**Signature:** Bios Fund I, LP By: Bios Equity Partners, LP, its general partner By: Cavu Management, LP, its general partner By: Cavu Advisors, LLC, its general partner By: /s/ John Fucci, as attorney-in-fact  
**Date:** 2025-06-30

**Signature:** Bios Fund I QP, LP By: Bios Equity Partners, LP, its general partner By: Cavu Management, LP, its general partner By: Cavu Advisors, LLC, its general partner By: /s/ John Fucci, as attorney-in-fact  
**Date:** 2025-06-30

**Signature:** Bios Equity Partners, LP By: Cavu Management, LP, its general partner By: Cavu Advisors, LLC, its general partner By: /s/ John Fucci, as attorney-in-fact  
**Date:** 2025-06-30

**Signature:** Bios Fund II, LP By: Bios Equity Partners II, LP, its general partner By: Cavu Management, LP, its general partner By: Cavu Advisors, LLC, its general partner By: /s/ John Fucci, as attorney-in-fact  
**Date:** 2025-06-30

**Signature:** Bios Fund II NT, LP By: Bios Equity Partners II, LP, its general partner By: Cavu Management, LP, its general partner By: Cavu Advisors, LLC, its general partner By: /s/ John Fucci, as attorney-in-fact  
**Date:** 2025-06-30

**Signature:** Bios Fund II QP, LP By: Bios Equity Partners II, LP, its general partner By: Cavu Management, LP, its general partner By: Cavu Advisors, LLC, its general partner By: /s/ John Fucci, as attorney-in-fact  
**Date:** 2025-06-30

**Signature:** Bios Equity Partners II, LP By: Cavu Management, LP, its general partner By: Cavu Advisors, LLC, its general partner By: /s/ John Fucci, as attorney-in-fact  
**Date:** 2025-06-30

### Remarks:

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

**Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.**