# EDGAR Filing Document

**Accession Number:** 0001070081
**File Stem:** 0001104659-23-036263
**Filing Date:** 2023-3
**Character Count:** 50365
**Document Hash:** b6f69aae803e6c48429067229a15c210
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-23-036263.hdr.sgml**: 20230324

**ACCESSION NUMBER**: 0001104659-23-036263

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 14

**CONFORMED PERIOD OF REPORT**: 20230322

**ITEM INFORMATION**: Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers

**ITEM INFORMATION**: Regulation FD Disclosure

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20230324

**DATE AS OF CHANGE**: 20230324

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** PTC THERAPEUTICS, INC.
- **CENTRAL INDEX KEY:** 0001070081
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 043416587
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-35969
- **FILM NUMBER:** 23757677

**BUSINESS ADDRESS:**
- **STREET 1:** 100 CORPORATE COURT
- **CITY:** SOUTH PLAINFIELD
- **STATE:** NJ
- **ZIP:** 07080-2449
- **BUSINESS PHONE:** 9082227000

**MAIL ADDRESS:**
- **STREET 1:** 100 CORPORATE COURT
- **CITY:** SOUTH PLAINFIELD
- **STATE:** NJ
- **ZIP:** 07080-2449

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** PTC THERAPEUTICS INC
- **DATE OF NAME CHANGE:** 19980909

?xml version="1.0" encoding="utf-8"?

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**FORM 8-K**

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**CURRENT REPORT**

**PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934**

**Date of Report (Date of earliest event reported)**: **March 22, 2023**

**PTC THERAPEUTICS, INC.**

**(Exact name of registrant as specified in charter)**

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| | | |
|:---|:---|:---|
| **Delaware** | **001-35969** | **04-3416587** |
| **(State or Other Jurisdiction <br> of Incorporation)** | **(Commission File Number)** | **(I.R.S. Employer<br> Identification No.)** |

---

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| |
|:---|
| **100 Corporate Court** |
| **South Plainfield, NJ 07080** |
| **(Address of Principal Executive Offices, including Zip Code)** |

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 **(908) 222-7000**

**(Registrant's telephone number, including area code)**

**(Former name or former address, if changed since last report.)**

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Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

◻ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

◻ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

◻ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

◻ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

**Securities registered pursuant to Section 12(b) of the Act:**

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| | | |
|:---|:---|:---|
| **Title of each class** | **Trading Symbol(s)** | **Name of each exchange on which <br> registered** |
| Common Stock, $0.001 par value per share | PTCT | Nasdaq Global Select Market |

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Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company&nbsp;&nbsp;&nbsp;&nbsp;◻

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.&nbsp;&nbsp;&nbsp;&nbsp; ◻

**Item 5.02. Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.**

*Chief Executive Officer Succession*

On March 22, 2023, the Board of Directors (the "Board") of PTC Therapeutics, Inc. (the "Company") appointed Dr. Matthew B. Klein, age 51, as Chief Executive Officer and President and a member of the Board, effective as of March 22, 2023. Dr. Klein succeeds Dr. Stuart W. Peltz, who provided the Board with notice on March 22, 2023 of his decision to retire as Chief Executive Officer and as a member of the Board, in each case, effective as of March 22, 2023. Dr. Klein is a Class I director with an initial term expiring at the Company's 2023 annual meeting of stockholders. In order to provide an orderly transition, Dr. Peltz will serve as a Senior Advisor to the Company and join its Scientific Advisory Board, as further described below.

Dr. Klein has served as the Company's Chief Operating Officer since January 2022. Dr. Klein joined the Company in October 2019 as Global Head Gene and Mitochondrial Therapies and became Global Head Clinical Development in March 2020 and Chief Development Officer in April 2020. Prior to joining the Company, Dr. Klein was Chief Executive Officer of BioElectron Technology Corporation, or BioElectron, from 2018 to 2019, and served as a member of the board of directors of BioElectron from 2018 to 2020. Dr. Klein served as the Chief Medical Officer of BioElectron from 2013 to 2019 and was Senior Vice President, Clinical Science at BioElectron from 2012 to 2013. Dr. Klein has also served as a member of the board of directors of ClearPoint Neuro, Inc., a Nasdaq-listed company, since 2020 as the Company's designee. Dr. Klein received a BA from the University of Pennsylvania, an MD from Yale University School of Medicine and an MS in epidemiology from the University of Washington School of Public Health.

No arrangement or understanding exists between Dr. Klein and any other person pursuant to which Dr. Klein was appointed as an officer or director of the Company. No family relationships exist between Dr. Klein and any director or officer of the Company. At the time of the acquisition of substantially all of the assets of BioElectron pursuant to an Asset Purchase Agreement by and between the Company and BioElectron, dated October 1, 2019, Dr. Klein was the Chief Executive Officer and director of BioElectron, and was a shareholder of BioElectron, owning approximately six percent of its outstanding shares. As a shareholder of BioElectron, Dr. Klein is entitled to receive a portion of any post-closing payments made to BioElectron pursuant to the Asset Purchase Agreement. No such payments have been made to BioElectron since the acquisition. Dr. Klein was not a related party at the time of the acquisition.

In connection with his retirement, the Company and Dr. Peltz entered into a consulting agreement (the "Consulting Agreement") pursuant to which Dr. Peltz will serve as a Senior Advisor to the Company and will provide consulting services to the Company from March 24, 2023, the date he terminates employment, until April 11, 2025 (subject to earlier termination, the "consulting period"). The Consulting Agreement provides that Dr. Peltz will receive a consulting fee of $600,000 in respect of his consulting services for the first twelve months of the consulting period and $400,000 in respect of his consulting services for the next twelve months of the consulting period (through March 24, 2025). Dr. Peltz and his eligible dependents will continue to receive group health insurance benefits until he becomes eligible for Medicare, subject to applicable law and the terms of the applicable policies and subject to a maximum amount of expenses. In addition, Dr. Peltz will continue to be eligible to receive a prorated 2023 annual bonus. The amount of such prorated 2023 annual bonus will be equal to 25% of Dr. Peltz's 2022 annual bonus and will be payable at the time bonuses are paid to the Company's executive officers. While Dr. Peltz serves on the Company's Scientific Advisory Board, he will be compensated for such services in accordance with the Company's policies. Unvested equity awards previously granted to Dr. Peltz will continue to be eligible to vest based on his continued service during the consulting period in accordance with their existing terms. Dr. Peltz also agreed to a release of claims relating to the end of his service as Chief Executive Officer and remains subject to certain continuing obligations in favor of the Company.

The foregoing descriptions of the material terms of the Consulting Agreement for Dr. Peltz do not purport to be complete and are qualified in their entirety by reference to the full text of the Consulting Agreement, a copy of which is attached as Exhibit 10.1 to this Current Report on Form 8-K and incorporated herein by reference.

**Item 7.01. Regulation FD Disclosure.**

On March 24, 2023, the Company issued a press release regarding the Chief Executive Officer succession. The Company will host a conference call on March 24, 2023 at 8:30 AM eastern time. Directions on how to access the conference call are included in the press release furnished as Exhibit 99.1 to this Current Report on Form 8-K.

The information in this Item 7.01, including Exhibit 99.1, is being furnished and shall not be deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities of that Section and shall not be deemed incorporated by reference into any registration statement or other document filed pursuant to the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, except as shall be expressly set forth by specific reference in such filing.

**Item 9.01. Financial Statements and Exhibits.**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) **Exhibits.**

---

| | |
|:---|:---|
| **Exhibit<br> No.** | **Description** |
| [10.1](tm2310367d1_ex10-1.htm) | [Consulting Agreement between PTC Therapeutics, Inc. and Stuart W. Peltz](tm2310367d1_ex10-1.htm) |
| [99.1](tm2310367d1_ex99-1.htm) | [Press release of the Company, dated March 24, 2023.](tm2310367d1_ex99-1.htm) |
| 104 | Cover Page Interactive Data File (formatted as Inline XBRL). |

---

**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

---

| | | |
|:---|:---|:---|
|  | PTC Therapeutics, inc. | PTC Therapeutics, inc. |
| Date: March 24, 2023 | By: | /s/ Mark E. Boulding |
|  | Name: | Mark E. Boulding |
|  | Title: | Executive Vice President and Chief Legal Officer |

---

## Exhibit 10.1

**Exhibit 10.1**

*Execution Version*

**CONSULTING AGREEMENT**

This CONSULTING AGREEMENT (this "Agreement") is entered into as of March 23, 2023 by and between PTC Therapeutics, Inc., a Delaware corporation (the "Company"), and Stuart W. Peltz, an individual ("Executive").

WHEREAS, effective as of March 24, 2023 (the "Effective Date"), Executive is retiring from his employment with the Company ("Retirement") after having retired from his position as Chief Executive Officer of the Company and a member of the Board of Directors of the Company (the "Board"), effective as of March 22, 2023;

WHEREAS, Executive has agreed to act as a consultant to the Company following his Retirement; and

WHEREAS, the Company and Executive desire to enter into this Agreement setting forth the terms of Executive's consulting relationship with the Company and certain other matters relating to his transition to a consulting role.

NOW, THEREFORE, in consideration of the premises and the mutual covenants and agreements herein contained, the parties hereto agree as follows:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1. **Consulting Services**. Executive hereby agrees to provide consulting services to the Company to accomplish the orderly transition of his duties as Chief Executive Officer, including with respect to the Company's management and key partnerships, as well as to provide certain other consulting and advisory services as may reasonably requested by the Company's Chief Executive Officer or the Chairman of the Board from time to time (collectively, the "Services"). In such capacity, Executive shall have the title of Senior Advisor and shall report directly to the Chief Executive Officer of the Company or the Chairman of the Board. The term of this Agreement will commence on the Effective Date and end on April 11, 2025, unless earlier terminated as provided herein (the "Consulting Period"). Executive agrees to devote that amount of time as is reasonably required by the Company for him to perform the Services, taking into account his other business obligations as in effect from time to time.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2. **Other Services; Scientific Advisory Board.** In addition to the Services, during the Consulting Period and thereafter Executive shall make himself reasonably available to the Company to assist in any litigation or potential litigation matter or any investigation or review of any federal, state or local regulatory authority that relates to events or occurrences that transpired while Executive provided services to the Company and shall serve on the Scientific Advisory Board of the Company.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3. **Independent Contractor**. From and after the Effective Date, Executive's relationship with the Company will be that of an independent contractor and not that of an employee. Executive will be solely responsible for determining the method, details and means of performing the Services. Executive will have no authority to enter into contracts that bind the Company or create obligations on the part of the Company without the prior written authorization of the Company. Executive acknowledges and agrees that he will not be eligible for any benefits available to employees of the Company. All of the Services to be performed by Executive will be as agreed between Executive and the Company's Chief Executive Officer and/or Chairman of the Board, and Executive will be required to report only to the Company's Chief Executive Officer or Chairman of the Board concerning the Services performed under this Agreement. The nature and frequency of these reports will be left to the discretion of the Company's Chief Executive Officer and/or Chairman of the Board. Except for the payment described in Section 4(b) below, Executive will have full responsibility for applicable taxes for all compensation paid to Executive under this Agreement and will have full responsibility for compliance with all applicable labor and employment requirements with respect to Executive's self-employment. Except for the payment described in Section 4(b) below, Executive agrees to indemnify, defend and hold the Company harmless from any liability for, or assessment of, any claims or penalties with respect to such taxes, labor or employment requirements, including any liability for, or assessment of, taxes imposed on the Company by the relevant taxing authorities with respect to liabilities of Executive attributable to any compensation paid to Executive in his capacity as a non-employee of the Company.

*Execution Version*

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4. **Compensation and Other Benefits**.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) **Consulting Fee**. As compensation for the Services provided hereunder, during the Consulting Period, the Company will pay to Executive a consulting fee (the "Consulting Fee") of (i) $600,000 for the first twelve (12) months of the Consulting Period beginning on the Effective Date, and (ii) $400,000 for the remaining twelve (12) months of the Consulting Period (it being understood that there shall be no Consulting Fee for the portion, if any, of the Consulting Period that extends from March 25, 2025 to April 11, 2025). The Consulting Fee will be paid to Executive on the first business day of each month during the Consulting Period, in arrears, and will be pro-rated for partial periods of service.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) **Prorated Annual Bonus**. Executive shall receive an annual bonus for the 2023 fiscal year in an amount equal to twenty-five percent (25%) of Executive's actual annual bonus for the 2022 fiscal year ($180,150), payable when 2023 annual bonuses are paid to executives of the Company generally.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) **Scientific Advisory Board**. During the Consulting Period, Executive shall receive compensation for his service on the Scientific Advisory Board in accordance with the Company's Scientific Advisory Board compensation policies for Scientific Advisory Board members as in effect from time to time. Notwithstanding anything to the contrary in this Agreement, Executive's service on the Scientific Advisory Board may be terminated by the Board at any time for any reason, without additional compensation due to Executive but payment to be made for any unpaid compensatory amounts attributable to such service at the time of termination.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) **Equity Awards**. The stock options previously granted to Executive by the Company that are outstanding and unexercised as of the Effective Date (the "Stock Options") and the restricted stock and restricted stock unit awards previously granted to Executive by the Company that are outstanding and unvested as of the Effective Date (collectively with the Stock Options, the "Equity Awards"), as evidenced in the Company's records, will remain outstanding and each of the Equity Awards that is unvested as of the Effective Date will continue to vest during the Consulting Period in accordance with the terms of the applicable equity plan and the equity award agreement between Executive and the Company ("Equity Documents") and subject to the provisions of this Agreement. With respect to any Stock Options that remain outstanding and unexercised as of the last day of the Consulting Period, such Stock Options shall remain exercisable by Executive until the earlier of (i) the date that is three (3) months following the last day of the Consulting Period (which date shall be extended to six (6) months following the last day of the Consulting Period for any Stock Options that vest in the six-month period immediately prior to the last day of the Consulting Period) and (ii) the stated expiration date of such Stock Options.

*Execution Version*

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) **Benefits**.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;i. During the eighteen (18)-month period following the Effective Date (the "Continuation Period"), the Company shall continue to provide Executive and his enrolled eligible dependents with group health insurance and shall continue to pay the amount of the premium as in effect on the Effective Date, subject to applicable law and the terms of the respective policies; provided that the Company's obligation to provide the benefits contemplated herein shall terminate upon Executive's obtaining coverage under the medical benefits program of a subsequent employer.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ii. At the end of the Continuation Period, Executive and his eligible dependents shall be permitted to continue to participate in the Company's group health insurance (or self-insurance) plan until such time as he is eligible for Medicare (the period of time that begins at the end of the Continuation Period and ends on the date that Executive becomes eligible for Medicare is referred to as the "Gap Period"); provided, that in no event shall the amount of additional direct costs associated with such participation exceed $250,000 (the "Maximum Amount"); and provided, further, that, if subsequent to Executive commencing participation through the Company's plan under this subsection, the Company determines in its reasonable discretion that Executive's and/or his eligible dependents' participation in the Company's plan is having or will have a direct material adverse effect on the Company's health insurance costs or plan choices, the Company can, upon sixty (60) days' notice, terminate Executive's ability to purchase insurance for himself and his eligible dependents through the Company's plan; and provided, further, that, Executive may, in his sole discretion, at any time prior to the beginning of the Gap Period, purchase health insurance coverage for the Gap Period in lieu of participating in the Company's group health insurance (or self-insurance) plan and, in such case, the Company shall reimburse him for the cost of such coverage up to the Maximum Amount (it being understood that in such case there shall be no duplication of benefits hereunder).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) **Reimbursable Expenses**. Executive shall be entitled to reimbursement for reasonable expenses incurred by him in connection with the performance of the Services in accordance with the applicable policies and procedures of the Company as in effect from time to time.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) **Administrative Support**. During the Consulting Period, the Company will provide Executive with reasonable levels of administrative support to support the provision of the Services hereunder.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) **Cooperation**. If Executive assists in any litigation or potential litigation matter or any investigation or review of any regulatory authority following the end of the Consulting Period, the Company shall compensate Executive at the rate of his per diem base salary in effective immediately prior to the Retirement and shall reimburse Executive for out-of-pocket expenses associated with such support.

*Execution Version*

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5. **Continuing Obligations**. The Company's obligations hereunder are conditioned upon Executive's compliance with his obligations under this Agreement and his continued compliance with any post-employment covenants to the Company, including those set forth in Section 5 or 6 of the Employment Agreement. In the event of any material noncompliance with the foregoing, in addition to any other remedies at law or in equity, the Company shall have the right to cease payment or the provisions of benefits hereunder and recoup amounts or benefits previously paid or provided.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;6. **Termination**.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) The Company may terminate this Agreement only for Cause, and Executive may terminate this Agreement upon giving thirty (30) days' advance written notice of such termination to the Company, in each case prior to the expiration of the Consulting Period.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) "Cause" shall be limited to Executive's willful refusal or failure to perform his material obligations hereunder (other than due to death or disability) that, if curable, is not cured within thirty (30) days of Executive's receipt of written notice from the Company containing reasonable specificity of such refusal or failure and a statement of corrective actions, or Executive's material failure to comply with any post-employment covenants to the Company, including those set forth in Section 5 or 6 of the Employment Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;7. **Effect of Termination**. If this Agreement is terminated by the Company for Cause or by Executive, in each case prior to the expiration of the Consulting Period, the Company's only obligation under this Agreement will be to pay Executive any earned but unpaid Consulting Fee as of the termination date. Executive's Equity Awards shall be treated as provided in the Equity Documents (without giving effect to any modifications hereunder). For the avoidance of doubt, upon a termination of this Agreement for any reason other than for Cause Executive shall retain his then vested benefits in accordance with their terms.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;8. **Continuing Obligations**. Executive acknowledges and agrees that he remains bound by his obligations under the Employment Agreement, which survive the termination of his employment by the terms thereof, including without limitation his obligations under Sections 5 and 6 of the Employment Agreement (such obligations, hereinafter referred to as the "Continuing Obligations"). Notwithstanding the foregoing, nothing in this Agreement or the Employment Agreement shall prevent or preclude Executive from engaging in or pursuing business or other commercial or noncommercial activities that do not violate the terms of the Continuing Obligations.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;9. **Section 409A of the Code**. This Agreement is intended to comply with, or be exempt from, the requirements of Section 409A of the Internal Revenue Code of 1986, as amended (the "Code"), and shall be construed consistent with such intent. Notwithstanding the foregoing, in no event shall the Company have any liability relating to the failure or alleged failure of any payment or benefit under this Agreement to comply with, or be exempt from, the requirements of Section 409A of the Code. Executive's right to payment or reimbursement for expenses under this Agreement will be subject to the following additional rules: (i) the amount of expenses eligible for payment or reimbursement during any calendar year shall not affect the expenses eligible for payment or reimbursement in any other calendar year, (ii) payment or reimbursement shall be made promptly, and in all events not later than December 31 of the calendar year following the calendar year in which the expense or payment was incurred, and (iii) the right to payment or reimbursement is not subject to liquidation or exchange for any other benefit.

*Execution Version*

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;10. **Certain Matters Relating to Termination of Employment.** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) **Resignations**. Executive acknowledges and agrees that as of March 22, 2023, Executive resigned from all: (i) officer positions he held with the Company and its subsidiaries and affiliates; (ii) memberships he held on the Board and any boards of directors, boards of managers or other governing boards or bodies of the Company and its subsidiaries and affiliates; and (iii) memberships he held on any of the committees of any such boards or bodies.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) **Final Compensation; No Severance**. Executive and the Company acknowledge and agree that Executive will be reimbursed by the Company for all business expenses incurred in conjunction with the performance of Executive's employment in accordance with Company policy. Executive and the Company further acknowledge and agree that Executive will receive payment in full for all services rendered in conjunction with Executive's employment by the Company through the Effective Date, including payment for all wages, bonuses and accrued, unused vacation time (in the amount of $387,700), and that no other compensation is owed to Executive except as provided in this Agreement. Without limiting the foregoing, Executive acknowledges and agrees that he is not eligible for any severance benefits in connection with or following his Retirement, including but not limited to under the Employment Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) **Return of Company Property**. Executive confirms that Executive has returned to the Company all keys, files, records (and copies thereof), and any other Company-owned property in Executive's possession or control and has left intact all electronic Company documents, including but not limited to those which he developed or helped to develop during his employment. Notwithstanding the foregoing, Executive may retain Executive's Company laptop, iPad, cellular phone and other electronic devices, provided that Executive surrenders on or around the Effective Date such devices to the Company to delete any confidential and other sensitive information related to his employment with the Company. Executive further confirms that he has cancelled all accounts for his benefit, if any, in the Company's name, including but not limited to, credit cards, telephone charge cards, cellular phone and/or wireless data accounts and computer accounts.

*Execution Version*

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) **Release**. In consideration of the payments and benefits set forth in this Agreement, which Executive acknowledges and agrees he would not otherwise be entitled to receive, Executive hereby fully, forever, irrevocably and unconditionally releases, remises and discharges the Company, its affiliates, subsidiaries, parent companies, predecessors, and successors, and all of their respective past and present officers, directors, stockholders, partners, members, employees, agents, representatives, plan administrators, attorneys, insurers and fiduciaries (each in their individual and corporate capacities) (collectively, the "Released Parties") from any and all claims, charges, complaints, demands, actions, causes of action, suits, rights, debts, sums of money, costs, accounts, reckonings, covenants, contracts, agreements, promises, doings, omissions, damages, executions, obligations, liabilities, and expenses (including attorneys' fees and costs), of every kind and nature that Executive ever had or now has against any or all of the Released Parties, including, but not limited to, any and all claims arising out of or relating to Executive's employment with and/or separation from the Company, including, but not limited to, all claims under Title VII of the Civil Rights Act of 1964, 42 U.S.C. § 2000e <u>et seq.</u>, the Americans With Disabilities Act of 1990, 42 U.S.C. § 12101 <u>et seq.</u>, the Age Discrimination in Employment Act, 29 U.S.C. § 621 <u>et seq.</u>, the Genetic Information Nondiscrimination Act of 2008, 42 U.S.C. § 2000ff <u>et seq.</u>, the Family and Medical Leave Act, 29 U.S.C. § 2601 <u>et seq.</u>, the Worker Adjustment and Retraining Notification Act ("WARN"), 29 U.S.C. § 2101 <u>et seq.</u>, the Rehabilitation Act of 1973, 29 U.S.C. § 701 <u>et seq.</u>, Executive Order 11246, Executive Order 11141, the Fair Credit Reporting Act, 15 U.S.C. § 1681 <u>et seq.</u>, and the Employee Retirement Income Security Act of 1974 ("ERISA"), 29 U.S.C. § 1001 <u>et seq.</u>, all as amended; all claims arising out of the New Jersey Law Against Discrimination, N.J. Stat. Ann. § 10:5-1 <u>et seq.</u>, the New Jersey Family Leave Act, N.J. Stat. Ann. § 34:11B-1 <u>et seq.</u>, the New Jersey Conscientious Employee Protection Act, N.J. Stat. Ann. § 34:19-1 <u>et seq.</u>, and the N.J. Stat. Ann. § 34:11-56.1 <u>et seq.</u> (New Jersey equal pay law), all as amended and all other similar state laws; all common law claims including, but not limited to, actions in defamation, intentional infliction of emotional distress, misrepresentation, fraud, wrongful discharge, and breach of contract, including without limitation, all claims arising from the Employment Agreement; all state and federal whistleblower claims to the maximum extent permitted by law; all claims to any non-vested ownership interest in the Company, contractual or otherwise; and any claim or damage arising out of Executive's employment with and/or separation from the Company (including a claim for retaliation) under any common law theory or any federal, state or local statute or ordinance not expressly referenced above; provided, however, that nothing in this Agreement shall (i) prevent Executive from filing a charge with, cooperating with, or participating in any proceeding before the Equal Employment Opportunity Commission or a state fair employment practices agency (except that Executive acknowledges that he may not recover any monetary benefits in connection with any such claim, charge or proceeding); (ii) deprive Executive of any accrued benefits to which he has acquired a vested right under any employee benefit plan or policy, stock plan or deferred compensation arrangement, any health care continuation to the extent required by applicable law or any agreement or any payments or benefits due under this Agreement, including any benefits with respect to Equity Awards as provided for under this Agreement; or (iii) deprive Executive of any rights Executive may have to be indemnified by the Company as provided in the Employment Agreement, any other agreement between the Company and Executive or pursuant to the Company's Certificate of Incorporation or by-laws or the Indemnification Agreement dated as of May 15, 2013 by and between the Company and Executive. This Release shall not extend to any claims Executive may have against any persons that are Released Parties to the extent such claims are (i) related solely to Executive's ownership of the Company's stock and (ii) unrelated to Executive's employment with the Company.

Executive acknowledges that the release of claims set forth in this Section 10(d) creates legally binding obligations, and that the Company has advised Executive to consult an attorney before signing it. In signing this Agreement, Executive gives the Company assurance that he has signed it voluntarily and with a full understanding of its terms; that Executive has had sufficient opportunity of not less than twenty-one (21) days before signing this Agreement to consider its terms and to consult with an attorney, if he wished to do so; and that Executive has not relied on any promises or representations, express or implied, that are not set forth expressly in this Agreement. Executive understands that he will have seven (7) days after signing this Agreement to revoke his signature, solely with respect to this Section 10(d), and that, if he intends to revoke his signature, he must do so in writing addressed and delivered to the General Counsel of the Company prior to the end of the seven (7)-day revocation period. Executive understands that this release of claims will become effective upon the eighth (8th) day following the date that he signs this, provided that he does not revoke my acceptance in accordance with the immediately preceding sentence. If the release of claims set forth in this Section 10(d) does not become effective, Executive shall not be entitled to receive any of the payments and benefits set forth in this Agreement, and the Company shall have no further obligation to Executive except as required by law.

*Execution Version*

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) **Non-Disparagement**. To the extent permitted by law, Executive understands and agrees that as a condition for payments and benefits under this Agreement, for a period of five years following the date hereof Executive shall not make any false, disparaging or derogatory statements to any person or entity, including any media outlet, regarding the Company or any of its directors, officers, employees, agents or representatives or about the Company's business affairs and financial condition. Executive further agrees that as a condition for payments and benefits under this Agreement any statements made by Executive regarding the Company shall be consistent in tenor, tone and content with the statements made in the press release filed by the Company on or around the date hereof announcing Executive's retirement. Further, for a period of five years following the date hereof, neither the Company, nor any of its executive officers or members of its Board of Directors of the Company will directly or indirectly make any false statement, observation or opinion, disparaging Executive's reputation. The Company further agrees that as a condition for Executive's entering into this Agreement any statements made by the Company regarding Executive shall be consistent in tenor, tone and content with the statements made in the press release filed by the Company on or around the date hereof announcing Executive's retirement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;11. **Miscellaneous**.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) **Entire Agreement**. This Agreement constitutes the sole agreement of the parties and supersedes all oral negotiations and prior writings with respect to the subject matter hereof; it being understood that the Continuing Obligations, the plans and agreements governing the Equity Awards and the provision of the Employment Agreement that are intended to survive the termination of such agreement as provided for in the Employment Agreement (other than Section 5 thereof) will remain outstanding and will survive in accordance with their terms.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) **Amendments and Waivers**. Any term of this Agreement may be amended or waived only with the written consent of the parties.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) **Choice of Law**. The validity, interpretation, construction and performance of this Agreement will be governed by the laws of the State of New Jersey, without giving effect to the principles of conflict of laws.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) **Severability**. If one or more provisions of this Agreement are held to be unenforceable under applicable law, such portion will be deemed to be modified or altered to the extent necessary to conform thereto or, if that is not possible, to be omitted from this Agreement. The invalidity of any such portion will not affect the force, effect, and validity of the remaining portion hereof.

*Execution Version*

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) **Indemnification**. The Company agrees that, during the Consulting Period, Executive shall be entitled to receive substantially similar indemnification coverage as provided to Executive as of immediately prior to the Effective Date to the same extent as if Executive were still an officer of the Company.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) **Counterparts**. This Agreement may be executed in counterparts, each of which will be deemed an original, but all of which together will constitute one and the same instrument.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) **Successors**. This Agreement is personal to Executive and, without the prior written consent of the Company, will not be assignable by Executive otherwise than by will or the laws of descent and distribution. This Agreement will inure to the benefit of and be enforceable by Executive's legal representatives. This Agreement will inure to the benefit of and be binding upon the Company and its successors and assigns. As used in this Agreement, "the Company" will mean both the Company as defined above and any such successor assign to or of the Company. The Company shall require that any successor or assign agree to perform this Agreement in the same manner as the Company.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) **Advice of Counsel**. EACH PARTY ACKNOWLEDGES THAT, IN EXECUTING THIS AGREEMENT, SUCH PARTY HAS HAD THE OPPORTUNITY TO SEEK THE ADVICE OF INDEPENDENT LEGAL COUNSEL, AND HAS READ AND UNDERSTOOD ALL OF THE TERMS AND PROVISIONS OF THIS AGREEMENT. THIS AGREEMENT SHALL NOT BE CONSTRUED AGAINST ANY PARTY BY REASON OF THE DRAFTING OR PREPARATION HEREOF.

[Remainder of page intentionally left blank.]

*Execution Version*

This Agreement has been executed as a sealed instrument by the Company, by its duly authorized representative, and by Executive.

---

| | |
|:---|:---|
| PTC THERAPEUTICS, INC. | PTC THERAPEUTICS, INC. |
| By: | /s/ Mark E. Boulding |
| Name: Mark E. Boulding | Name: Mark E. Boulding |
| Title: Executive Vice President and Chief Legal Officer | Title: Executive Vice President and Chief Legal Officer |

---

---

| | |
|:---|:---|
| STUART W. PELTZ | STUART W. PELTZ |
| Signature: | /s/ Stuart W. Peltz |

---

## Exhibit 99.1

**Exhibit 99.1**

**Stuart Peltz, Ph.D., Rare Disease Pioneer, to Retire**

**as Chief Executive Officer of PTC Therapeutics**

*- Chief Operating Officer Matthew Klein, M.D., M.S., F.A.C.S. to become*

*Chief Executive Officer and join the Board of Directors –*

*- Conference call to be held today, Fri., March 24<sup>th</sup> at 8:30 am ET -*

**SOUTH PLAINFIELD, N.J., March 24, 2023 /** **PTC Therapeutics, Inc. (NASDAQ: PTCT**). Stuart Peltz, Ph.D., founding Chief Executive Officer (CEO) of PTC Therapeutics announced today that he is stepping down after 25 years. Dr. Peltz has led PTC Therapeutics as its CEO since its founding in 1998 and pioneered the field of RNA-directed drug development. Under his leadership, PTC has grown from a research organization with expertise in the control of RNA processes to a publicly traded, integrated, global biopharmaceutical company focused on the discovery, development and commercialization of innovative therapies for the treatment of neurological and neuromuscular disorders, metabolic disorders, and cancer.

"I have been involved with PTC almost since its inception. What Stuart and the team have achieved in 25 years is extraordinary," said Michael Schmertzler, Chairman of the Board of Directors. "The Board and I are confident in the team Stuart has built and their ability to continue to deliver transformative treatments to those living with rare diseases. We wish Stuart all the best in his future endeavors and look forward to his continuing contributions to the company."

Matthew Klein, M.D., M.S., F.A.C.S., current Chief Operating Officer, has been named the company's CEO and will join the Board of Directors. The transition is effective immediately. Dr. Peltz will serve as a Senior Consultant to the Company and join its Scientific Advisory Board following his retirement.

Prior to joining PTC in 2019, Dr. Klein was CEO and Chief Medical Officer at BioElectron Technology Corporation, a biotechnology company focused on the development of redox-active small molecules for mitochondrial disease and related disorders of oxidative stress. PTC acquired BioElectron's assets in 2019.

As CEO and CMO of BioElectron, Dr. Klein led the restructuring of the company with successful implementation of new strategic and operational plans and led the development of two novel small molecules targeting CNS diseases from discovery to early and late clinical development stages. In addition, he oversaw the formation of an oncology platform that yielded several novel preclinical compounds with novel approaches to targeting cancer.

Dr. Klein joined PTC as Global Head of Gene & Mitochondrial Therapies and then assumed the role of Chief Development Officer prior to promotion to COO in January 2022. At PTC, he has overseen the Company's broad development pipeline now with five ongoing registration-directed clinical trials and headed the efforts in achieving EMA approval for Upstaza, the first ever gene therapy directly administered to the brain.

Dr. Klein holds a Bachelor of Arts in history, and graduated summa cum laude and phi beta kappa from the University of Pennsylvania. He received his Doctor of Medicine degree with honors from Yale University. In addition, Dr. Klein holds a Masters of Epidemiology degree from the University of Washington. Prior to leading BioElectron, he was the Auth-Washington Research Foundation Endowed Chair for Restorative Burn Surgery at the University of Washington. He has authored or co-authored over 100 peer-reviewed scientific publications and has served on the Research Advisory Board of the Shriners Hospitals for Children for over 15 years.

"The PTC team and patients and families around the world have benefited tremendously from Stu's scientific expertise and leadership. I am grateful to the Board for its confidence in appointing me as his successor," said Dr. Klein. "I am extremely proud to have the opportunity to lead PTC's experienced and dedicated team into its next quarter century as we advance our pioneering science to develop valuable and transformative therapies for children and adults with unmet medical needs. We will enrich PTC's unwavering commitments to patients and to prudent enterprise growth based on our robust product portfolio, global commercial infrastructure, and unique scientific and drug development strengths."

**Today's Conference Call and Webcast information:**

To access the call by phone, please <u>click here</u> to register and you will be provided with dial-in details. To avoid delays, we recommend participants dial in to the conference call 15 minutes prior to the start of the call. The webcast conference call can be accessed on the Investor section of the PTC website at <u>https://ir.ptcbio.com/events-presentations</u>. A replay of the call will be available approximately two hours after completion of the call and will be archived on the company's website for 30 days following the call.

**About PTC Therapeutics, Inc.**

PTC is a science-driven, global biopharmaceutical company focused on the discovery, development and commercialization of clinically differentiated medicines that provide benefits to patients with rare disorders. PTC's ability to globally commercialize products is the foundation that drives investment in a robust and diversified pipeline of transformative medicines and our mission to provide access to best-in-class treatments for patients who have an unmet medical need. The company's strategy is to leverage its strong scientific expertise and global commercial infrastructure to maximize value for its patients and other stakeholders. To learn more about PTC, please visit us at <u>www.ptcbio.com</u> and follow us on Facebook, on Twitter at @PTCBio, and on LinkedIn.

**For More Information:**

**Investors:**<br> Kylie O'Keefe<br> +1 (908) 300-0691<br> <u>kokeefe@ptcbio.com</u>

**Media:**<br> Jeanine Clemente<br> +1 (908) 912-9406<br> <u>jclemente@ptcbio.com</u>

**Forward-Looking Statements:**

This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. All statements contained in this release, other than statements of historic fact, are forward-looking statements, including statements regarding PTC's strategy, future operations, future financial position, future revenues, projected costs; and the objectives of management. Other forward-looking statements may be identified by the words "guidance," "plan," "anticipate," "believe," "estimate," "expect," "intend," "may," "target," "potential," "will," "would," "could," "should," "continue," and similar expressions.

PTC's actual results, performance or achievements could differ materially from those expressed or implied by forward-looking statements it makes as a result of a variety of risks and uncertainties, including the factors discussed in the "Risk Factors" section of PTC's most recent Annual Report on Form 10-K as well as any updates to these risk factors filed from time to time in PTC's other filings with the SEC. You are urged to carefully consider all such factors.

The forward-looking statements contained herein represent PTC's views only as of the date of this press release and PTC does not undertake or plan to update or revise any such forward-looking statements to reflect actual results or changes in plans, prospects, assumptions, estimates or projections, or other circumstances occurring after the date of this press release except as required by law.