# EDGAR Filing Document

**Accession Number:** 0001699737
**File Stem:** 0001104659-23-021929
**Filing Date:** 2023-2
**Character Count:** 29266
**Document Hash:** e917d4f877da910bfc146c72667d432e
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-23-021929.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001104659-23-021929

**CONFORMED SUBMISSION TYPE**: SC 13D

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**GROUP MEMBERS**: SAMSARA BIOCAPITAL GP, LLC

**GROUP MEMBERS**: SRINIVAS AKKARAJU, MD, PHD

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Scholar Rock Holding Corp
- **CENTRAL INDEX KEY:** 0001727196
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **IRS NUMBER:** 823750435
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13D
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-90496
- **FILM NUMBER:** 23631324

**BUSINESS ADDRESS:**
- **STREET 1:** 301 BINNEY STREET
- **STREET 2:** 3RD FLOOR
- **CITY:** CAMBRIDGE
- **STATE:** MA
- **ZIP:** 02142
- **BUSINESS PHONE:** 857-259-3860

**MAIL ADDRESS:**
- **STREET 1:** 301 BINNEY STREET
- **STREET 2:** 3RD FLOOR
- **CITY:** CAMBRIDGE
- **STATE:** MA
- **ZIP:** 02142
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Samsara BioCapital, L.P.
- **CENTRAL INDEX KEY:** 0001699737
- **IRS NUMBER:** 813958301
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13D

**BUSINESS ADDRESS:**
- **STREET 1:** 628 MIDDLEFIELD ROAD
- **CITY:** PALO ALTO
- **STATE:** CA
- **ZIP:** 94301
- **BUSINESS PHONE:** (650) 285-4270

**MAIL ADDRESS:**
- **STREET 1:** 628 MIDDLEFIELD ROAD
- **CITY:** PALO ALTO
- **STATE:** CA
- **ZIP:** 94301

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**SCHEDULE 13D**

**Under the Securities Exchange Act of 1934**

**(Amendment No.)\***

**Scholar Rock Holding Corporation**

(Name of Issuer)

**Common Stock, par value $0.001 per share**

(Title of Class of Securities)

**80706P 10 3**

(CUSIP Number)

**Miran Ahmad**

**Chief Financial Officer**

**Samsara BioCapital GP, LLC**

**628 Middlefield Road**

**Palo Alto, CA 94301**

**(650) 285-4270**

(Name, Address and Telephone Number of Person

Authorized to Receive Notices and Communications)

**June 22, 2022**

(Date of Event Which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. ¨

**Note**: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Rule 13d-7 for other parties to whom copies are to be sent.

\* The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

---

| | | | | |
|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;CUSIP No. 80706P 10 3 | &nbsp;&nbsp;CUSIP No. 80706P 10 3 | &nbsp;&nbsp;CUSIP No. 80706P 10 3 | &nbsp;&nbsp;CUSIP No. 80706P 10 3 | &nbsp;&nbsp;CUSIP No. 80706P 10 3 |
| 1. | &nbsp;&nbsp; Names of Reporting Persons<br>Samsara BioCapital, L.P. | &nbsp;&nbsp; Names of Reporting Persons<br>Samsara BioCapital, L.P. | &nbsp;&nbsp; Names of Reporting Persons<br>Samsara BioCapital, L.P. | &nbsp;&nbsp; Names of Reporting Persons<br>Samsara BioCapital, L.P. |
| 2. | &nbsp;&nbsp;Check the Appropriate Box if a Member of a Group (See Instructions) | &nbsp;&nbsp;Check the Appropriate Box if a Member of a Group (See Instructions) | &nbsp;&nbsp;Check the Appropriate Box if a Member of a Group (See Instructions) | &nbsp;&nbsp;Check the Appropriate Box if a Member of a Group (See Instructions) |
|  | &nbsp;&nbsp; (a)<br>(b) | &nbsp;&nbsp; ◻<br>⌧ (1) | &nbsp;&nbsp; ◻<br>⌧ (1) | &nbsp;&nbsp; ◻<br>⌧ (1) |
| 3. | &nbsp;&nbsp;SEC Use Only | &nbsp;&nbsp;SEC Use Only | &nbsp;&nbsp;SEC Use Only | &nbsp;&nbsp;SEC Use Only |
| 4. | &nbsp;&nbsp; Source of Funds (See Instructions)<br>WC | &nbsp;&nbsp; Source of Funds (See Instructions)<br>WC | &nbsp;&nbsp; Source of Funds (See Instructions)<br>WC | &nbsp;&nbsp; Source of Funds (See Instructions)<br>WC |
| 5. | &nbsp;&nbsp;Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ☐ | &nbsp;&nbsp;Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ☐ | &nbsp;&nbsp;Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ☐ | &nbsp;&nbsp;Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ☐ |
| 6. | &nbsp;&nbsp; Citizenship or Place of Organization<br>Delaware | &nbsp;&nbsp; Citizenship or Place of Organization<br>Delaware | &nbsp;&nbsp; Citizenship or Place of Organization<br>Delaware | &nbsp;&nbsp; Citizenship or Place of Organization<br>Delaware |
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 7. | &nbsp;&nbsp; Sole Voting Power<br>|
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 8. | &nbsp;&nbsp; Shared Voting Power<br>5,663,632 shares (2) |
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 9. | &nbsp;&nbsp; Sole Dispositive Power<br>|
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 10. | &nbsp;&nbsp; Shared Dispositive Power<br>5,663,632 shares (2) |
| 11. | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br>5,663,632 shares (2) | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br>5,663,632 shares (2) | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br>5,663,632 shares (2) | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br>5,663,632 shares (2) |
| 12. | &nbsp;&nbsp;Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) ☐ | &nbsp;&nbsp;Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) ☐ | &nbsp;&nbsp;Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) ☐ | &nbsp;&nbsp;Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) ☐ |
| 13. | &nbsp;&nbsp; Percent of Class Represented by Amount in Row (11)<br>10.7% (3) | &nbsp;&nbsp; Percent of Class Represented by Amount in Row (11)<br>10.7% (3) | &nbsp;&nbsp; Percent of Class Represented by Amount in Row (11)<br>10.7% (3) | &nbsp;&nbsp; Percent of Class Represented by Amount in Row (11)<br>10.7% (3) |
| 14. | &nbsp;&nbsp; Type of Reporting Person (See Instructions)<br>PN | &nbsp;&nbsp; Type of Reporting Person (See Instructions)<br>PN | &nbsp;&nbsp; Type of Reporting Person (See Instructions)<br>PN | &nbsp;&nbsp; Type of Reporting Person (See Instructions)<br>PN |

---

&nbsp;&nbsp;&nbsp;&nbsp;(1) This Schedule 13D is filed by Samsara BioCapital, L.P. ("Samsara LP"), Samsara BioCapital GP,
LLC ("Samsara GP" and together with Samsara LP, the "Samsara Entities"), the sole general partner of Samsara LP,
and Srinivas Akkaraju ("Mr. Akkaraju" and together with the Samsara Entities, the "Reporting Persons"), managing
member of Samsara GP. The Reporting Persons expressly disclaim status as a "group" for purposes of this Schedule 13D.

&nbsp;&nbsp;&nbsp;&nbsp;(2) Consists of (i) 4,598,828 shares of the Issuer's Common Stock held by Samsara LP and (ii) 1,064,804
shares of Common Stock issuable upon exercise of warrants held by Samsara LP. Samsara GP is the general partner of Samsara LP and Mr.
Akkaraju is the managing member of Samsara GP. Samsara LP, Samsara GP and Mr. Akkaraju share power to direct the voting and disposition
of the shares held by Samsara LP and may be deemed to beneficially own the securities held by Samsara LP.

&nbsp;&nbsp;&nbsp;&nbsp;(3) The beneficial ownership percentage is based on 51,663,391 shares of the Issuer's Common Stock outstanding
as of November 8, 2022, as reported on the Issuer's Quarterly Report on Form 10-Q for the quarter ended September 30, 2022, filed
with the Securities and Exchange Commission (the "SEC") on November 14, 2022, as adjusted in accordance with Rule 13d-3 under
the Securities Exchange Act of 1934, as amended (the "Act").

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;CUSIP No. 80706P 10 3 | &nbsp;&nbsp;CUSIP No. 80706P 10 3 | &nbsp;&nbsp;CUSIP No. 80706P 10 3 |
| 1. | &nbsp;&nbsp; Names of Reporting Persons<br>Samsara BioCapital GP, LLC | &nbsp;&nbsp; Names of Reporting Persons<br>Samsara BioCapital GP, LLC |
| 2. | &nbsp;&nbsp;Check the Appropriate Box if a Member of a Group (See Instructions) | &nbsp;&nbsp;Check the Appropriate Box if a Member of a Group (See Instructions) |
|  | &nbsp;&nbsp; ◻<br>x (1) | &nbsp;&nbsp; ◻<br>x (1) |
| 3. | &nbsp;&nbsp;SEC Use Only | &nbsp;&nbsp;SEC Use Only |
| 4. | &nbsp;&nbsp; Source of Funds (See Instructions)<br>AF | &nbsp;&nbsp; Source of Funds (See Instructions)<br>AF |
| 5. | &nbsp;&nbsp;Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ☐ | &nbsp;&nbsp;Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ☐ |
| 6. | &nbsp;&nbsp; Citizenship or Place of Organization<br>Delaware | &nbsp;&nbsp; Citizenship or Place of Organization<br>Delaware |
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 7. | &nbsp;&nbsp; Sole Voting Power<br>|
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 8. | &nbsp;&nbsp; Shared Voting Power<br>5,663,632 shares (2) |
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 9. | &nbsp;&nbsp; Sole Dispositive Power<br>|
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 10. | &nbsp;&nbsp; Shared Dispositive Power<br>5,663,632 shares (2) |
| 11. | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br>5,663,632 shares (2) | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br>5,663,632 shares (2) |
| 12. | &nbsp;&nbsp;Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) ☐ | &nbsp;&nbsp;Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) ☐ |
| 13. | &nbsp;&nbsp; Percent of Class Represented by Amount in Row (11)<br>10.7% (3) | &nbsp;&nbsp; Percent of Class Represented by Amount in Row (11)<br>10.7% (3) |
| 14. | &nbsp;&nbsp; Type of Reporting Person (See Instructions)<br>OO | &nbsp;&nbsp; Type of Reporting Person (See Instructions)<br>OO |

---

&nbsp;&nbsp;&nbsp;&nbsp;(1) This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as
a "group" for purposes of this Schedule 13D.

&nbsp;&nbsp;&nbsp;&nbsp;(2) Consists of (i) 4,598,828 shares of the Issuer's Common Stock held by Samsara LP and (ii) 1,064,804
shares of Common Stock issuable upon exercise of warrants held by Samsara LP. Samsara GP is the general partner of Samsara LP and Mr.
Akkaraju is the managing member of Samsara GP. Samsara LP, Samsara GP and Mr. Akkaraju share power to direct the voting and disposition
of the shares held by Samsara LP and may be deemed to beneficially own the securities held by Samsara LP.

&nbsp;&nbsp;&nbsp;&nbsp;(3) The beneficial ownership percentage is based on 51,663,391 shares of the Issuer's Common Stock outstanding
as of November 8, 2022, as reported on the Issuer's Quarterly Report on Form 10-Q for the quarter ended September 30, 2022, filed
with the SEC on November 14, 2022, as adjusted in accordance with Rule 13d-3 under the Act.

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;CUSIP No. 80706P 10 3 | &nbsp;&nbsp;CUSIP No. 80706P 10 3 | &nbsp;&nbsp;CUSIP No. 80706P 10 3 |
| 1. | &nbsp;&nbsp; Names of Reporting Persons<br>Srinivas Akkaraju, MD, PhD | &nbsp;&nbsp; Names of Reporting Persons<br>Srinivas Akkaraju, MD, PhD |
| 2. | &nbsp;&nbsp;Check the Appropriate Box if a Member of a Group (See Instructions) | &nbsp;&nbsp;Check the Appropriate Box if a Member of a Group (See Instructions) |
|  | &nbsp;&nbsp; ◻<br>x (1) | &nbsp;&nbsp; ◻<br>x (1) |
| 3. | &nbsp;&nbsp;SEC Use Only | &nbsp;&nbsp;SEC Use Only |
| 4. | &nbsp;&nbsp; Source of Funds (See Instructions)<br>AF | &nbsp;&nbsp; Source of Funds (See Instructions)<br>AF |
| 5. | &nbsp;&nbsp;Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ☐ | &nbsp;&nbsp;Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) ☐ |
| 6. | &nbsp;&nbsp; Citizenship or Place of Organization<br>United States | &nbsp;&nbsp; Citizenship or Place of Organization<br>United States |
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 7. | &nbsp;&nbsp; Sole Voting Power<br>12,444 (2) |
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 8. | &nbsp;&nbsp; Shared Voting Power<br>5,663,632 shares (3) |
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 9. | &nbsp;&nbsp; Sole Dispositive Power<br>12,444 (2) |
| &nbsp;&nbsp; Number of<br> Shares<br> Beneficially<br> Owned by<br> Each<br> Reporting<br> Person With | 10. | &nbsp;&nbsp; Shared Dispositive Power<br>5,663,632 shares (3) |
| 11. | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br>5,676,076 shares (2)(3) | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br>5,676,076 shares (2)(3) |
| 12. | &nbsp;&nbsp;Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) ☐ | &nbsp;&nbsp;Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) ☐ |
| 13. | &nbsp;&nbsp; Percent of Class Represented by Amount in Row (11)<br>10.8% (4) | &nbsp;&nbsp; Percent of Class Represented by Amount in Row (11)<br>10.8% (4) |
| 14. | &nbsp;&nbsp; Type of Reporting Person (See Instructions)<br>IN | &nbsp;&nbsp; Type of Reporting Person (See Instructions)<br>IN |

---

&nbsp;&nbsp;&nbsp;&nbsp;(1) This Schedule 13D is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as
a "group" for purposes of this Schedule 13D.

&nbsp;&nbsp;&nbsp;&nbsp;(2) Consists of 12,444 shares of Common Stock issuable upon the exercise of stock options held by Mr. Akkaraju
that are vested and exercisable within 60 days of the date hereof.

&nbsp;&nbsp;&nbsp;&nbsp;(3) Consists of (i) 4,598,828 shares of the Issuer's Common Stock held by Samsara LP and (ii) 1,064,804
shares of Common Stock issuable upon exercise of a warrant held by Samsara LP. Samsara GP is the general partner of Samsara LP and Mr.
Akkaraju is the managing member of Samsara GP. Samsara LP, Samsara GP and Mr. Akkaraju share power to direct the voting and disposition
of the shares held by Samsara LP and may be deemed to beneficially own the shares held by Samsara LP.

&nbsp;&nbsp;&nbsp;&nbsp;(4) The beneficial ownership percentage is based on 51,663,391 shares of the Issuer's Common Stock outstanding
as of November 8, 2022, as reported on the Issuer's Quarterly Report on Form 10-Q for the quarter ended September 30, 2022, filed
with the SEC on November 14, 2022, as adjusted in accordance with Rule 13d-3 under the Act.

Item 1. Security and Issuer

The class of equity security to which this statement on Schedule 13D relates is the Common Stock, par value $0.001 per share ("Common Stock") of Scholar Rock Holding Corporation, a Delaware corporation (the "Issuer"). The address of the principal executive offices of the Issuer is 301 Binney Street, 3rd Floor, Cambridge, Massachusetts 02142.

Information given in response to each item shall be deemed incorporated by reference in all other items, as applicable.

Item 2. Identity and Background

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Samsara BioCapital, L.P. ("Samsara LP"), Samsara BioCapital GP, LLC ("Samsara GP"
and together with Samsara LP, the "Samsara Entities") and Srinivas "Srini" Akkaraju, MD, PhD ("Mr. Akkaraju"
and, collectively with the Samsara Entities, the "Reporting Persons"). The Reporting Persons expressly disclaim status as
a "group" for purposes of this Schedule 13D.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) The principal business office of the Reporting Persons is c/o Samsara BioCapital GP, LLC, 628 Middlefield
Road, Palo Alto, CA 94301.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) The principal business of the Reporting Persons is venture capital investments.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) During the last five years, none of the Reporting Persons has been convicted in a criminal proceeding
(excluding traffic violations or similar misdemeanors).

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) During the last five years, none of the Reporting Persons was a party to a civil proceeding of a judicial
of administrative body of competent jurisdiction or were subject to a judgment, decree or final order enjoining future violations of,
or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) Each of the Samsara Entities was organized in the state of Delaware and Mr. Akkaraju is a citizen of the
United States.

### Item 3. Source and Amount of Funds or Other Consideration
On June 17, 2022, Samsara LP, along with other purchasers, entered into a Securities Purchase Agreement (the "Purchase Agreement") with the Issuer in connection with a registered offering undertaken by the Issuer (the "Registered Direct Offering"). Pursuant to the Purchase Agreement, Samsara LP purchased 4,259,217 shares of Common Stock (the "RD Shares") and received accompanying warrants (the "RD Warrants" and collectively with the RD Shares, the "RD Securities") to purchase up to 1,064,804 shares of Common Stock. The offering price per RD Share and associated Warrant was $4.90 per share. Samsara LP's aggregate purchase price of the RD Securities was $20.9 million. The source of the funds for the purchase by Samsara LP described above was from capital contributions made by its general and limited partners.

Item 4. Purpose of Transaction

The Reporting Persons purchased the aforementioned securities for investment purposes with the aim of increasing the value of their investments and the Issuer. Subject to applicable legal requirements, one or more of the Reporting Persons may purchase additional securities of the Issuer from time to time in open market or private transactions, depending on its evaluation of the Issuer's business, prospects and financial condition, the market for the Issuer's securities, other developments concerning the Issuer, the reaction of the Issuer to the Reporting Persons' ownership of the Issuer's securities, other opportunities available to the Reporting Persons, and general economic, money market and stock market conditions. In addition, depending upon the factors referred to above, the Reporting Persons may dispose of all or a portion of their securities of the Issuer at any time. Each of the Reporting Persons reserves the right to increase or decrease its holdings on such terms and at such times as each may decide.

Except as set forth in this Item 4 and Item 6 below, none of the Reporting Persons have a present plan or proposal that relates to or would result in any of the actions specified in clauses (a) through (j) of Item 4 of Schedule 13D of the Securities Exchange Act of 1934 (the "Act"). However, each of the Reporting Persons reserves the right to propose or participate in future transactions which may result in one or more of such actions, including but not limited to, an extraordinary corporate transaction, such as a merger, reorganization or liquidation, sale of a material amount of assets of the Issuer or its subsidiaries, or other transactions which might have the effect of causing the Common Stock to become eligible for termination of registration under Section 12(g) of the Act. The Reporting Persons also retain the right to change their investment intent at any time, to acquire additional shares of Common Stock or other securities of the Issuer from time to time, or to sell or otherwise dispose of all or part of the Common Stock beneficially owned by them (or any shares of Common Stock into which such securities are converted) in any manner permitted by law. The Reporting Persons may engage from time to time in ordinary course transactions with financial institutions with respect to the securities described herein.

On July 26, 2022, Mr. Akkaraju joined the board of directors of the Issuer. As a director of the Issuer, he may have influence over the corporate activities of the Issuer, including activities which may relate to the transactions described in clauses (a) through (j) of Item 4 of Schedule 13D.

Item 5. Interest in Securities of the Issuer

(a) – (b). The following information with respect to the ownership of the Common Stock of the Issuer by the persons filing this statement on Schedule 13D is provided as of February 14, 2023:

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| **Reporting Persons** | **Securities<br> Held<br> Directly (1)** | **Sole Voting<br> Power (1)** | **Shared<br> Voting<br> Power (1)** | **Sole<br> Dispositive<br> Power** | **Shared<br> Dispositive<br> Power(1)** | **Beneficial<br> Ownership<br> (1)** | **Percentage<br> of Class (2)** |
| Samsara LP | 5663632 |  | 5663632 |  | 5663632 | 5663632 | 10.7% |
| Samsara GP |  |  | 5663632 |  | 5663632 | 5663632 | 10.7% |
| Mr. Akkaraju | 12444 | 12444 | 5663632 | 12444 | 5663632 | 5676076 | 10.8% |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) Consists of (i) 4,598,828 shares of the Issuer's Common Stock held by Samsara LP and (ii) 1,064,804
shares of Common Stock issuable upon exercise of Warrants held by Samsara LP. Samsara GP is the general partner of Samsara LP and Mr.
Akkaraju is the managing member of Samsara GP. Samsara LP, Samsara GP and Mr. Akkaraju share power to direct the voting and disposition
of the securities held by Samsara LP and may be deemed to beneficially own the shares held by Samsara LP. For Mr. Akkaraju, also includes
12,444 shares of Common Stock issuable upon the exercise of stock options held by Mr. Akkaraju that are vested and exercisable within
60 days of the date hereof.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) The beneficial ownership percentage is based on 51,663,391 shares of the Issuer's Common Stock outstanding
as of November 8, 2022, as reported on the Issuer's Quarterly Report on Form 10-Q for the quarter ended September 30, 2022, filed
with the SEC on November 14, 2022, as adjusted in accordance with Rule 13d-3 under the Act.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Except as set forth herein, none of the Reporting Persons has effected any transactions in shares of the
Issuer's Common Stock during the last 60 days.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) No other person is known to have the right to receive or the power to direct the receipt of dividends
from, or any proceeds from the sale of, the shares of Common Stock beneficially owned by any of the Reporting Persons.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) Not applicable.

Item 6. Contracts, Arrangements, Understandings or Relationships with Respect to Securities of the Issuer

*Warrants*

As described in Item 3, Samsara LP received 1,064,804 Warrants in the RD Offering. Each Warrant has an exercise price per share of $7.35, is immediately exercisable and will expire on December 31, 2025. Samsara LP may not exercise the Warrants if it, together with its affiliates, would beneficially own more than 19.99% of the number of shares of the Common Stock outstanding immediately after giving effect to such exercise. Samsara LP may decrease this percentage by providing at least 61 days' prior notice to the Issuer.

The description of the Warrants set forth above is not complete and is qualified in its entirety by reference to the full text of the form of Warrant, which is filed as an exhibit to this Schedule 13D and is incorporated by reference herein.

*Director Compensation* 

As a non-employee director of the Issuer, Mr. Akkaraju is eligible to receive equity compensation for his service as a director. On September 16, 2022, Mr. Akkaraju received a stock option to purchase up to 56,000 shares of Common Stock at an exercise price of $8.91 per share. This option vests monthly over the three years following the date Mr. Akkaraju joined the board of directors, subject to Mr. Akkaraju's continuous service on the board of directors through the applicable vesting dates.

Other than as described in Items 3, 4, 5 and this Item 6, and the agreements and instruments filed as exhibits hereto, to the Reporting Persons' knowledge, there are no contracts, arrangements, understandings or relationships (legal or otherwise) among the persons named in Item 2 and between such persons and any person with respect to any securities of the Issuer.

Item 7. Material to be Filed as Exhibits

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;A. Joint Filing Agreement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;B. Form of Common Stock Warrant (incorporated by reference to Exhibit 4.2 of the Issuer's Current Report
on Form 8-K (File No. 001-38501), filed on June 21, 2022).

**Signature**

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Dated: February 14, 2023

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| | |
|:---|:---|
| **SAMSARA BIOCAPITAL, L.P.**<br> **By: Samsara BioCapital GP, LLC**<br> **Its: General Partner** | **SAMSARA BIOCAPITAL, L.P.**<br> **By: Samsara BioCapital GP, LLC**<br> **Its: General Partner** |
| By: | /s/ Srinivas Akkaraju |
| Srinivas Akkaraju | Srinivas Akkaraju |
| Managing Member | Managing Member |
| **SAMSARA BIOCAPITAL GP, LLC** | **SAMSARA BIOCAPITAL GP, LLC** |
| By: | /s/ Srinivas Akkaraju |
| Srinivas Akkaraju | Srinivas Akkaraju |
| Managing Member | Managing Member |
| **SRINIVAS AKKARAJU** | **SRINIVAS AKKARAJU** |
| /s/ Srinivas Akkaraju | /s/ Srinivas Akkaraju |

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| | |
|:---|:---|
|  | &nbsp;&nbsp;**ATTENTION** |
| &nbsp;&nbsp;**Intentional misstatements or omissions of fact constitute Federal Criminal Violations (See 18 U.S.C. 1001).** | &nbsp;&nbsp;**Intentional misstatements or omissions of fact constitute Federal Criminal Violations (See 18 U.S.C. 1001).** |

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**Exhibit(s):**

A Joint Filing Agreement

EXHIBIT A

JOINT FILING AGREEMENT

The undersigned hereby agree that a single Schedule 13D (or any amendment thereto) relating to the Common Stock of Scholar Rock Holding Corporation shall be filed on behalf of each of the undersigned and that this Agreement shall be filed as an exhibit to such Schedule 13D.

Dated: February 14, 2023

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| | |
|:---|:---|
| **SAMSARA BIOCAPITAL, L.P.**<br> **By: Samsara BioCapital GP, LLC**<br> **Its: General Partner** | **SAMSARA BIOCAPITAL, L.P.**<br> **By: Samsara BioCapital GP, LLC**<br> **Its: General Partner** |
| By: | /s/ Srinivas Akkaraju |
| Srinivas Akkaraju | Srinivas Akkaraju |
| Managing Member | Managing Member |
| **SAMSARA BIOCAPITAL GP, LLC** | **SAMSARA BIOCAPITAL GP, LLC** |
| By: | /s/ Srinivas Akkaraju |
| Srinivas Akkaraju | Srinivas Akkaraju |
| Managing Member | Managing Member |
| **SRINIVAS AKKARAJU** | **SRINIVAS AKKARAJU** |
| /s/ Srinivas Akkaraju | /s/ Srinivas Akkaraju |

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