# EDGAR Filing Document

**Accession Number:** 0001894562
**File Stem:** 0001628280-23-007302
**Filing Date:** 2023-3
**Character Count:** 16943
**Document Hash:** eecb6aa2dcec077b39d20db54316e0f9
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001628280-23-007302.hdr.sgml**: 20230309

**ACCESSION NUMBER**: 0001628280-23-007302

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 5

**FILED AS OF DATE**: 20230309

**DATE AS OF CHANGE**: 20230309

**EFFECTIVENESS DATE**: 20230309

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Prime Medicine, Inc.
- **CENTRAL INDEX KEY:** 0001894562
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-270400
- **FILM NUMBER:** 23719978

**BUSINESS ADDRESS:**
- **STREET 1:** 21 ERIE ST.
- **CITY:** CAMBRIDGE
- **STATE:** MA
- **ZIP:** 02139
- **BUSINESS PHONE:** 617-465-0013

**MAIL ADDRESS:**
- **STREET 1:** 21 ERIE ST.
- **CITY:** CAMBRIDGE
- **STATE:** MA
- **ZIP:** 02139

**As filed with the Securities and Exchange Commission on March 9, 2023** 

**Registration No. 333-** 

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**Washington, D.C. 20549** 

**FORM S-8** 

**REGISTRATION STATEMENT** 

***Under***

***The Securities Act of 1933***

**Prime Medicine, Inc.** 

**(Exact name of registrant as specified in its charter)** 

---

| | |
|:---|:---|
| **Delaware** | **84-3097762** |
| **(State or other jurisdiction of**<br>**incorporation or organization)** | **(I.R.S. Employer**<br>**Identification Number)** |

---

**21 Erie Street**

**Cambridge, MA 02139** 

**(617) 564-0013** 

**(Address of Principal Executive Offices)** 

**Prime Medicine, Inc. 2022 Stock Option and Incentive Plan**

**Prime Medicine, Inc. 2022 Employee Stock Purchase Plan** 

**(Full Title of the Plans)** 

**Keith Gottesdiener, M.D.**

**President and Chief Executive Officer** 

**Prime Medicine, Inc.** 

**21 Erie Street** 

**Cambridge, MA 02139** 

**(617) 564-0013** 

**(Name, address, including zip code, and telephone number, including area code, of agent for service)** 

***Copies to:***

**Kingsley L. Taft, Esq.**

**Marishka DeToy, Esq.**

**Goodwin Procter LLP** 

**100 Northern Avenue** 

**Boston, Massachusetts 02210** 

**(617) 570-1000** 

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| Large accelerated filer | ☐ | Accelerated filer | ☐ | Non-accelerated filer | ☒ | Smaller reporting company | ☒ | Emerging growth company | ☒ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

ACTIVE/121637943.2 <br>

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ACTIVE/121637943.2 <br>

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**PART I** 

**INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS** 

This Registration Statement on Form S-8 is being filed for the purpose of registering (i) an additional 4,860,461 shares of common stock, par value $0.00001 per share ("Common Stock") of Prime Medicine, Inc. (the "Registrant") to be issued under the Registrant's 2022 Stock Option and Incentive Plan, as amended (the "2022 Plan") and (ii) an additional 971,350 shares of Common Stock of the Registrant to be issued under the Registrant's 2022 Employee Stock Purchase Plan (the "2022 ESPP"), for which a Registration Statement on Form S-8 (File No. 333-267953) relating to the same employee benefit plans is effective.

These additional shares are of the same class as other securities relating to the 2022 Plan and 2022 ESPP for which the Registrant's Registration Statement on Form S-8 (File No. 333-267953) filed with the Commission on October 19, 2022 is effective.

Pursuant to General Instruction E to Form S-8, the contents of the Registration Statement on Form S-8 (File No. 333-267953) filed with the Commission on October 19, 2022 are incorporated by reference except to the extent supplemented, amended or superseded by the information set forth herein. Only those items of Form S-8 containing new information not contained in the earlier registration statement is presented herein.

**Part II** 

**INFORMATION REQUIRED IN THE REGISTRATION STATEMENT** 

**Item 8. Exhibits.** 

The exhibits to this Registration Statement are listed in the Exhibit Index attached hereto and incorporated by reference herein.

ACTIVE/121637943.2 <br>

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**EXHIBIT INDEX** 

---

| | |
|:---|:---|
| **Exhibit<br>No.** | **Description** |
| 4.1 | <u>[Third Amended and Restated Certificate of Incorporation of Prime Medicine, Inc. (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K, filed with the SEC on October 24, 2022)](https://www.sec.gov/Archives/edgar/data/1894562/000162828022026895/exhibit31-closing8xk.htm)</u> |
| 4.2 | <u>[Amended and Restated Bylaws of Prime Medicine, Inc. (incorporated by reference to Exhibit 3.2 to the Registrant's Current Report on Form 8-K, filed with the SEC on October 24, 2022)](https://www.sec.gov/Archives/edgar/data/1894562/000162828022026895/exhibit32-closing8xk.htm)</u> |
| 4.3 | <u>[Specimen stock certificate evidencing the shares of common stock (incorporated by reference to Exhibit 4.2 to the Registrant's Registration Statement on Form S-1/A (File No. 333-267579) filed on October 17, 2022)](https://www.sec.gov/Archives/edgar/data/1894562/000162828022025424/exhibit42-livesx1.htm)</u> |
| 5.1\* | <u>[Opinion of Goodwin Procter LLP](primes-8x51opinionfinal.htm)</u> |
| 23.1\* | <u>[Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting Firm](prme-sx8consentfinal.htm)</u> |
| 23.2\* | <u>[Consent of Goodwin Procter LLP (included in Exhibit 5.1)](primes-8x51opinionfinal.htm)</u> |
| 24.1\* | Power of Attorney (included on signature page) |
| 99.1 | <u>[2022 Stock Option and Incentive Plan and forms of award agreements thereunder (Incorporated by reference to Exhibit 10.2 to the registrant's Registration Statement on Form S-1, as amended (File No. 333-267579)](https://www.sec.gov/Archives/edgar/data/1894562/000162828022026329/exhibit102-sx1a.htm)[filed on October 17, 2022](https://www.sec.gov/Archives/edgar/data/1894562/000162828022026329/exhibit102-sx1a.htm)</u> |
| 99.2 | <u>[2022 Employee Stock Purchase Plan (Incorporated by reference to Exhibit 10.3 to the registrant's Registration Statement on Form S-1, as amended (File No. 333-267579)](https://www.sec.gov/Archives/edgar/data/1894562/000162828022026329/exhibit103-sx1a.htm)</u> filed on October 17, 2022 |
| 107\* | <u>[Filing Fee Table](primes-8ex107filingfeetabl.htm)</u> |

---

\* Filed herewith.

ACTIVE/121637943.2 <br>

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**SIGNATURES** 

Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Cambridge, Commonwealth of Massachusetts, on the 9th day of March, 2023.

---

| | |
|:---|:---|
| **PRIME MEDICINE, INC.** | **PRIME MEDICINE, INC.** |
| By: | /s/ Keith Gottesdiener |
|  | Name: Keith Gottesdiener<br>Title: President and Chief Executive Officer |

---

**POWER OF ATTORNEY AND SIGNATURES** 

KNOW ALL BY THESE PRESENT, that each individual whose signature appears below hereby constitutes and appoints each of Keith Gottesdiener and Carman Alenson as such person's true and lawful attorney-in-fact and agent with full power of substitution and resubstitution, for such person in such person's name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement on Form S-8, and to file the same, with all exhibits thereto, and all documents in connection therewith, with the Securities and Exchange Commission granting unto each said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as such person might or could do in person, hereby ratifying and confirming all that any said attorney-in-fact and agent, or any substitute or substitutes of any of them, may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

---

| | | |
|:---|:---|:---|
| **Name** | **Title** | **Date** |
| /s/ Keith Gottesdiener | President, Chief Executive Officer and Director | March 9, 2023 |
| Keith Gottesdiener | (Principal Executive Officer) |  |
|  | &nbsp;&nbsp;&nbsp;C |  |
| /s/ Carman Alenson | Interim Chief Financial Officer and Chief Accounting Officer | March 9, 2023 |
| Carman Alenson | (Principal Accounting Officer and<br>Principal Financial Officer) |  |
| /s/ Robert Nelsen | Director | March 9, 2023 |
| Robert Nelsen |  |  |
| /s/ David Schenkein | Director | March 9, 2023 |
| David Schenkein |  |  |
| /s/ Thomas Cahill | Director | March 9, 2023 |
| Thomas Cahill |  |  |
| /s/ Michael Kelly | Director | March 9, 2023 |
| Michael Kelly |  |  |
| /s/ Wendy Chung | Director | March 9, 2023 |
| Wendy Chung |  |  |
| /s/ Kaye Foster | Director | March 9, 2023 |
| Kaye Foster |  |  |

---

ACTIVE/121637943.2 <br>

## Ex-Filing

**Exhibit 107**

**Calculation of Filing Fee Table**

**Form S-8**

(Form Type)

**Prime Medicine, Inc.** 

(Exact Name of Registrant as Specified in its Charter)

<u>Table 1: Newly Registered Securities</u>

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| **Security**<br>**Type** | **Security**<br>**Class**<br>**Title** | **Fee**<br>**Calculation**<br>**Rule** | **Amount**<br>**to be**<br>**Registered(1)** | **Proposed**<br>**Maximum**<br>**Offering**<br>**Price per**<br>**Share** | **Maximum**<br>**Aggregate**<br>**Offering**<br>**Price** | **Fee Rate** | **Amount of**<br>**Registration**<br>**Fee** |
| Equity | Common Stock, $0.00001 par value per share | Other (2) | 4,860,461 shares (3) | $15.64 (2) | $76017610.04 (2) | $0.0001102 | $8377.15 |
| Equity | Common Stock, $0.00001 par value per share | Other (4) | 971,350 shares (5) | $13.30 (4) | $12918955.00 (4) | $0.0001102 | $1423.67 |
| **Total Offering Amounts** | **Total Offering Amounts** | **Total Offering Amounts** | **Total Offering Amounts** |  | $88936565.04 |  | - |
| **Total Fees Previously Paid** | **Total Fees Previously Paid** | **Total Fees Previously Paid** | **Total Fees Previously Paid** |  |  |  | - |
| **Total Fee Offsets** | **Total Fee Offsets** | **Total Fee Offsets** | **Total Fee Offsets** |  |  |  | - |
| **Net Fee Due** | **Net Fee Due** | **Net Fee Due** | **Net Fee Due** |  |  |  | $9800.82 |

---

(1) Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "Securities Act"), this registration statement shall be deemed to cover any additional shares of common stock, $0.00001 par value per share ("Common Stock") which become issuable under the Registrant's 2022 Stock Option and Incentive Plan (the "2022 Plan") and the Registrant's 2022 Employee Stock Purchase Plan (the "2022 ESPP"), by reason of any stock dividend, stock split, recapitalization or any other similar transaction effected without the receipt of consideration which results in an increase in the number of the Registrant's outstanding shares of Common Stock.

(2) Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457 (c) and 457(h) of the Securities Act, and based upon the average of the high and low prices reported for the Common Stock on the Nasdaq Global Market on March 7 , 2023.

(3) Represents shares of Common Stock that were added to the shares authorized for issuance under the 2022 Plan, effective as of January 1, 2023 pursuant to an "evergreen" provision contained in the 2022 Plan. Pursuant to such provision, an additional number of shares will automatically be added to the shares authorized for issuance under the 2022 Plan on January 1 of each year. Shares available for issuance under the 2022 Plan were previously registered on registration statement on Form S-8 filed with the Securities and Exchange Commission on October 19, 2022 (File No. 333-267953).

(4) The price of $13.30 per share, which is 85% of the average of the high and low sale prices of the Common Stock of the Registrant as quoted on the Nasdaq Global Market on March 7, 2023 , is set forth solely for purposes of calculating the registration fee pursuant to Rules 457(c) and (h) of the Securities Act of 1933, as amended, and has been used as these shares are without a fixed price. Pursuant to the 2022 ESPP, the purchase price of the shares of Common Stock reserved for issuance thereunder will be 85% of the fair market value of a share of Common Stock on the first trading day of the offering period or on the exercise date, whichever is less.

(5) Represents shares of Common Stock that were added to the shares authorized for issuance under the 2022 ESPP, effective as of January 1, 2023 pursuant to an "evergreen" provision contained in the 2022 ESPP. Pursuant to such provision, an additional number of shares will automatically be added to the shares authorized for issuance under the 2022 ESPP on January 1 of each year. Shares available for issuance under the 2022 ESPP were previously registered on registration statements on Form S-8 filed with the Securities and Exchange Commission on October 19, 2022 (File No. 333-267953).

ACTIVE/121637979.3 <br>

## Exhibit 5.1

**Exhibit 5.1**

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| | |
|:---|:---|
| ![logoa.jpg](logoa.jpg) | Goodwin Procter llp<br>100 Northern Avenue<br>Boston, MA 02210<br>goodwinlaw.com<br>+1 617 570 1000 |

---

March 9, 2023

**Prime Medicine, Inc.**

21 Erie Street

Cambridge, MA 02139

**Re: <u>Securities Being Registered under Registration Statement on Form S-8</u>**

We have acted as counsel to you in connection with your filing of a Registration Statement on Form S-8 (the "Registration Statement") pursuant to the Securities Act of 1933, as amended (the "Securities Act"), on or about the date hereof relating to an aggregate of 5,831,811 shares (the "Shares") of Common Stock, $0.00001 par value per share ("Common Stock"), of Prime Medicine, Inc., a Delaware corporation (the "Company"), that may be issued pursuant to the Company's 2022 Stock Option and Incentive Plan and 2022 Employee Stock Purchase Plan (collectively, the "Plans").

We have reviewed such documents and made such examination of law as we have deemed appropriate to give the opinions set forth below. We have relied, without independent verification, on certificates of public officials and, as to matters of fact material to the opinion set forth below, on certificates of officers of the Company.

The opinion set forth below is limited to the Delaware General Corporation Law.

For purposes of the opinion set forth below, we have assumed that no event occurs that causes the number of authorized shares of Common Stock available for issuance by the Company to be less than the number of then unissued Shares.

Based on the foregoing, we are of the opinion that the Shares have been duly authorized and, upon issuance and delivery against payment therefor in accordance with the terms of the Plans, will be validly issued, fully paid and nonassessable.

This opinion letter and the opinion it contains shall be interpreted in accordance with the Core Opinion Principles as published in 74 Business Lawyer 815 (Summer 2019).

We hereby consent to the inclusion of this opinion as Exhibit 5.1 to the Registration Statement. In giving our consent, we do not admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations thereunder.

Very truly yours,<br>/s/ GOODWIN PROCTER LLP<br>GOODWIN PROCTER LLP<br>

ACTIVE/121638106.2 <br>

## Exhibit 23.1

**Exhibit 23.1**

**CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM**

We hereby consent to the incorporation by reference in this Registration Statement on Form S-8 of Prime Medicine, Inc. of our report dated March 9, 2023 relating to the financial statements, which appears in Prime Medicine, Inc.'s Annual Report on Form 10-K for the year ended December 31, 2022.

/s/ PricewaterhouseCoopers LLP

Boston, Massachusetts <br>March 9, 2023

<br>