# EDGAR Filing Document

**Accession Number:** 0001539029
**File Stem:** 0001193125-25-319171
**Filing Date:** 2025-12
**Character Count:** 7048
**Document Hash:** 40662a1a1704f93a21be882e22fe6407
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-25-319171.hdr.sgml**: 20251215

**ACCESSION NUMBER**: 0001193125-25-319171

**CONFORMED SUBMISSION TYPE**: POS AM

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20251215

**DATE AS OF CHANGE**: 20251215

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Clearside Biomedical, Inc.
- **CENTRAL INDEX KEY:** 0001539029
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 452437375
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** POS AM
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-235880
- **FILM NUMBER:** 251571520

**BUSINESS ADDRESS:**
- **STREET 1:** 900 NORTH POINT PARKWAY
- **STREET 2:** SUITE 200
- **CITY:** ALPHARETTA
- **STATE:** GA
- **ZIP:** 30005
- **BUSINESS PHONE:** 678-270-3631

**MAIL ADDRESS:**
- **STREET 1:** 900 NORTH POINT PARKWAY
- **STREET 2:** SUITE 200
- **CITY:** ALPHARETTA
- **STATE:** GA
- **ZIP:** 30005

**As filed with the Securities and Exchange Commission on December 15, 2025** 

**Registration No. 333-235880** 

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**WASHINGTON, D.C. 20549** 

**POST-EFFECTIVE AMENDMENT NO. 1 TO** 

**FORM S-3** 

**REGISTRATION STATEMENT NO. 333-235880** 

***UNDER***

***THE SECURITIES ACT OF 1933***

## Clearside Biomedical, Inc.
**(Exact name of registrant as specified in its charter)** 

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| | |
|:---|:---|
| **Delaware** | **45-2437375** |
| **(State or other jurisdiction of**<br> **incorporation or organization)** | **(I.R.S Employer**<br> **Identification Number)** |

---

**900 North Point Parkway, Suite 200** 

**Alpharetta, Georgia 30005** 

**(Address, including zip code, and telephone number, including area code, of registrant's principal executive offices)** 

**George Lasezkay, Pharm.D., J.D.** 

**President and Chief Executive Officer** 

**Clearside Biomedical, Inc.** 

**900 North Point Parkway, Suite 200** 

**Alpharetta, Georgia 30005** 

**(678) 270-3631** 

**(Name, address, including zip code, and telephone number, including area code, of agent for service)** 

***Copies to:***

**Mark Ballantyne** 

**Paul Alexander** 

**Cooley LLP** 

**11951 Freedom Drive** 

**Reston, VA 20190** 

**(703) 456-8000** 

**Approximate date of commencement of proposed sale to the public:** Not applicable. The registrant is filing this post-effective amendment to remove from registration any securities registered hereunder that remain unsold.

If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box: ☐

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box: ☐

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐

If this Form is a registration statement pursuant to General Instruction I.D. or a post-effective amendment thereto that shall become effective upon filing with the Commission pursuant to Rule 462(e) under the Securities Act, check the following box. ☐

If this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.D. filed to register additional securities or additional classes of securities pursuant to Rule 413(b) under the Securities Act, check the following box. ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.

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| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☐ | Accelerated filer | ☐ |
| Non-accelerated filer | ☒ | Smaller reporting company | ☒ |
|  |  | Emerging growth company | ☐ |

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If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

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**DEREGISTRATION OF SECURITIES** 

Clearside Biomedical, Inc., a Delaware corporation (the "***Company***"), is filing this post-effective amendment No. 1 (the "***Post-Effective Amendment***") to the Registration Statement on Form S-3, [Registration File No. 333-235880](http://www.sec.gov/Archives/edgar/data/1539029/000156459020000761/clsd-s3.htm) (the "***Registration Statement***"), which was previously filed with the U.S. Securities and Exchange Commission (the "***SEC***") on January 10, 2020, and declared effective on January 17, 2020, to register the resale of an aggregate of 3,178,367 shares of the Company's common stock, par value $0.001 per share, by certain selling stockholders pursuant to the applicable prospectus included in the Registration Statement.

By filing this Post-Effective Amendment, the Company has terminated the offerings of its securities pursuant to the Registration Statement. Accordingly, the Company hereby terminates the effectiveness of the Registration Statement and, in accordance with an undertaking made by the Company in Part II of the Registration Statement to remove from registration, by means of post-effective amendment, removes from registration any and all of its securities that remain unsold under the Registration Statement as of the date hereof. The Registration Statement is hereby amended, as appropriate, to reflect the deregistration of all such securities

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**SIGNATURES** 

Pursuant to the requirements of the Securities Act of 1933, as amended, the Company certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and has duly caused this Post-Effective Amendment to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Alpharetta, State of Georgia, on this 15th day of December, 2025.

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| | |
|:---|:---|
| **CLEARSIDE BIOMEDICAL , INC.** | **CLEARSIDE BIOMEDICAL , INC.** |
| By: | /s/ Charles A. Deignan |
|  | Charles A. Deignan<br> Chief Financial Officer |

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No other person is required to sign this Post-Effective Amendment in reliance upon Rule 478 under the Securities Act of 1933, as amended.