# EDGAR Filing Document

**Accession Number:** 0001716947
**File Stem:** 0001493152-26-016449
**Filing Date:** 2026-4
**Character Count:** 2508
**Document Hash:** b09f6be9dfac5730ecf7c9db3dff700d
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001493152-26-016449.hdr.sgml**: 20260513

**ACCESSION NUMBER**: 0001493152-26-016449

**CONFORMED SUBMISSION TYPE**: CORRESP

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20260414

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Ensysce Biosciences, Inc.
- **CENTRAL INDEX KEY:** 0001716947
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 822755287
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** CORRESP

**BUSINESS ADDRESS:**
- **STREET 1:** 7946 IVANHOE AVENUE
- **STREET 2:** SUITE 201
- **CITY:** LA JOLLA
- **STATE:** CA
- **ZIP:** 92037
- **BUSINESS PHONE:** (858) 263-4196

**MAIL ADDRESS:**
- **STREET 1:** 7946 IVANHOE AVENUE
- **STREET 2:** SUITE 201
- **CITY:** LA JOLLA
- **STATE:** CA
- **ZIP:** 92037

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Leisure Acquisition Corp.
- **DATE OF NAME CHANGE:** 20170913

**Ensysce Biosciences, Inc.**

**7946 Ivanhoe Avenue, Suite 201**

**La Jolla, California 92037**

April 14, 2026

**VIA EDGAR**

U.S. Securities and Exchange Commission

Division of Corporation Finance

Office of Life Sciences

100 F Street, NE

Washington, D.C. 20549

Attention: Alan Campbell, Esq.

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| | |
|:---|:---|
| Re: | Ensysce Biosciences, Inc. |
|  | Registration Statement on Form S-3 |
|  | SEC File No. 333-294939 |
|  | Filed April 9, 2026 |

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Ladies and Gentlemen:

Pursuant to Rule 461 of Regulation C of the General Rules and Regulations under the Securities Act of 1933, as amended, Ensysce Biosciences, Inc. hereby requests that the effective date of the above-referenced Registration Statement be accelerated to 10:00 AM, Eastern Time, on April 15, 2026, or as soon thereafter as is practicable, or at such other time thereafter as our counsel, Troutman Pepper Locke LLP, may request by telephone. Once the Registration Statement has been declared effective, please orally confirm that event with our counsel, Troutman Pepper Locke LLP, by calling Gregory Rubis at (609) 951-4105.

Please direct any questions or comments concerning this request to Gregory Rubis.

---

| | |
|:---|:---|
| **ENSYSCE BIOSCIENCES, Inc.** | **ENSYSCE BIOSCIENCES, Inc.** |
| By: | */s/ Lynn Kirkpatrick* |
| Name: | Dr. Lynn Kirkpatrick |
| Title: | President and Chief Executive Officer |

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cc: Eric D. Kline, Troutman Pepper Locke LLP <br> Gregory Rubis, Troutman Pepper Locke LLP