# EDGAR Filing Document

**Accession Number:** 0001039803
**File Stem:** 0001752724-23-041179
**Filing Date:** 2023-2
**Character Count:** 25024
**Document Hash:** d91884ec93922241085e0599b6d9be29
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001752724-23-041179.hdr.sgml**: 20230227

**ACCESSION NUMBER**: 0001752724-23-041179

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230227

**DATE AS OF CHANGE**: 20230227

**PERIOD START**: 20221231

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** ProFunds
- **CENTRAL INDEX KEY:** 0001039803
- **IRS NUMBER:** 522035197
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-08239
- **FILM NUMBER:** 23670971

**BUSINESS ADDRESS:**
- **STREET 1:** 7272 WISCONSIN AVENUE
- **STREET 2:** 21ST FLOOR
- **CITY:** BETHESDA
- **STATE:** MD
- **ZIP:** 20814
- **BUSINESS PHONE:** 2404976428

**MAIL ADDRESS:**
- **STREET 1:** 7272 WISCONSIN AVENUE
- **STREET 2:** 21ST FLOOR
- **CITY:** BETHESDA
- **STATE:** MD
- **ZIP:** 20814

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** PROFUNDS
- **DATE OF NAME CHANGE:** 19970521

## Series and Classes Contracts Data

### PROFUND VP BIOTECHNOLOGY (Series ID: S000003965)

| Class ID   | Class Name               | Ticker Symbol   |
|:---|:---|:---|
| C000011092 | PROFUND VP BIOTECHNOLOGY |  |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** ProFunds

- **b. Investment Company Act file number:** 811-08239

- **c. CIK number of Registrant:** 0001039803

- **d. LEI of Registrant:** 549300HM4OOUYSE5DP77

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 7272 Wisconsin Avenue

  - **City:** Bethesda

  - **State:** MD

  - **Foreign country:** US

  - **Zip / Postal Code:** 20814

  - **Telephone number:** 240-497-6400

**Item A.2. Information about the Series.**

- **a. Name of Series:** ProFund VP Biotechnology

- **b. EDGAR series identifier (if any):** S000003965

- **c. LEI of Series:** G74DJGSGIKRN0SEEG418

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2022-12-31

- **b. Date as of which information is reported:** 2022-12-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $49492313.04

**Total Liabilities:** $138346.50

**Net Assets:** $49353966.54

**Cash Not Reported:** $265234.34

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000011092 | 9.24%                | 8.06%                | -2.92%               |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $25010.73                | $3719700.02                                |
| Month 2  | $-8.94                   | $3790075.55                                |
| Month 3  | $137250.46               | $-1565108.29                               |

**Designated Index Information**

- **Index Name:** Dow Jones U.S. Biotechnology Index

- **Index Identifier:** DJUSBT

### Schedule of Portfolio Investments

| Name                                           | Title                                                                       | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| SAREPTA THERAPEUTICS, INC.                     | SAREPTA THERAPEUTICS INC                                                    | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |      2750 | NS      | $356345.00    | 0.72%             |  |  |  | No            |                  1 | On Loan: No      |
| NATERA, INC.                                   | NATERA INC                                                                  | CUSIP: 632307104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3415 | NS      | $137180.55    | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| IONIS PHARMACEUTICALS, INC.                    | IONIS PHARMACEUTICALS INC                                                   | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |      4449 | NS      | $168038.73    | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| CANADIAN IMPERIAL BANK                         | CANADIAN IMPERIAL BANK                                                      | CUSIP: N/A<br>LEI: N/A                        | Long             | RA               | CORP              | US        |     71000 | PA      | $71000.00     | 0.14%             |  |  |  | No            |                  2 | On Loan: No      |
| 10X Genomics Inc                               | 10X GENOMICS INC                                                            | CUSIP: 88025U109<br>LEI: 5493003Z6741WNLG7H43 | Long             | EC               | CORP              | US        |      2994 | NS      | $109101.36    | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Denali Therapeutics Inc                        | DENALI THERAPEUTICS INC                                                     | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |      3446 | NS      | $95833.26     | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| INTELLIA THERAPEUTICS, INC.                    | INTELLIA THERAPEUTICS INC                                                   | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |      2670 | NS      | $93156.30     | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| AGILENT TECHNOLOGIES, INC.                     | AGILENT TECHNOLOGIES                                                        | CUSIP: 00846U101<br>LEI: QUIX8Y7A2WP0XRMW7G29 | Long             | EC               | CORP              | US        |      9273 | NS      | $1387704.45   | 2.81%             |  |  |  | No            |                  1 | On Loan: No      |
| MODERNA, INC.                                  | MODERNA INC                                                                 | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |     10349 | NS      | $1858887.38   | 3.77%             |  |  |  | No            |                  1 | On Loan: No      |
| CREDIT AGRICOLE CIB NY                         | CREDIT AGRICOLE CIB NY                                                      | CUSIP: N/A<br>LEI: N/A                        | Long             | RA               | CORP              | US        |    385000 | PA      | $385000.00    | 0.78%             |  |  |  | No            |                  2 | On Loan: No      |
| APELLIS PHARMACEUTICALS, INC.                  | APELLIS PHARMACEUTICALS INC                                                 | CUSIP: 03753U106<br>LEI: 254900HS0ZFRXXSB9D42 | Long             | EC               | CORP              | US        |      2944 | NS      | $152234.24    | 0.31%             |  |  |  | No            |                  1 | On Loan: No      |
| SYNEOS HEALTH, INC.                            | SYNEOS HEALTH INC                                                           | CUSIP: 87166B102<br>LEI: 549300F1ZGKDS8P6GU13 | Long             | EC               | CORP              | US        |      3223 | NS      | $118219.64    | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Ultragenyx Pharmaceutical Inc                  | ULTRAGENYX PHARMACEUTICAL INC                                               | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |      2196 | NS      | $101740.68    | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| NEUROCRINE BIOSCIENCES, INC.                   | NEUROCRINE BIOSCIENCES INC                                                  | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |      3011 | NS      | $359633.84    | 0.73%             |  |  |  | No            |                  1 | On Loan: No      |
| Blueprint Medicines Corp                       | BLUEPRINT MEDICINES CORP                                                    | CUSIP: 09627Y109<br>LEI: 5299004CC60O9T5HVM83 | Long             | EC               | CORP              | US        |      1874 | NS      | $82099.94     | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| MEDPACE HOLDINGS, INC.                         | MEDPACE HOLDINGS                                                            | CUSIP: 58506Q109<br>LEI: 549300H8TYEUVTW14A54 | Long             | EC               | CORP              | US        |       789 | NS      | $167591.49    | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| ROYAL BANK OF CANADA                           | ROYAL BANK OF CANADA                                                        | CUSIP: N/A<br>LEI: N/A                        | Long             | RA               | CORP              | US        |    250000 | PA      | $250000.00    | 0.51%             |  |  |  | No            |                  2 | On Loan: No      |
| REGENERON PHARMACEUTICALS, INC.                | REGENERON PHARMACEUTICALS                                                   | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |      3354 | NS      | $2419877.46   | 4.90%             |  |  |  | No            |                  1 | On Loan: No      |
| SEAGEN INC.                                    | SEAGEN INC                                                                  | CUSIP: 81181C104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4304 | NS      | $553107.04    | 1.12%             |  |  |  | No            |                  1 | On Loan: No      |
| DANAHER CORPORATION                            | DANAHER CORP                                                                | CUSIP: 235851102<br>LEI: S4BKK9OTCEWQ3YHPFM11 | Long             | EC               | CORP              | US        |     20522 | NS      | $5446949.24   | 11.04%            |  |  |  | No            |                  1 | On Loan: No      |
| Mirati Therapeutics Inc                        | MIRATI THERAPEUTICS INC                                                     | CUSIP: 60468T105<br>LEI: 529900GYRW59IDQV6N54 | Long             | EC               | CORP              | US        |      1623 | NS      | $73538.13     | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Maravai LifeSciences Holdings Inc              | MARAVAI LIFESCIENCES HOLDINGS INC                                           | CUSIP: 56600D107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3420 | NS      | $48940.20     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| UNITED THERAPEUTICS CORPORATION                | UNITED THERAPEUTICS CORP                                                    | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |      1428 | NS      | $397112.52    | 0.80%             |  |  |  | No            |                  1 | On Loan: No      |
| CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CHARLES RIVER LABORATORIES                                                  | CUSIP: 159864107<br>LEI: 549300BSQ0R4UZ5KX287 | Long             | EC               | CORP              | US        |      1594 | NS      | $347332.60    | 0.70%             |  |  |  | No            |                  1 | On Loan: No      |
| BIO-TECHNE CORPORATION                         | BIO TECHNE CORP                                                             | CUSIP: 09073M104<br>LEI: 54930073RLKQ51TILZ35 | Long             | EC               | CORP              | US        |      4917 | NS      | $407520.96    | 0.83%             |  |  |  | No            |                  1 | On Loan: No      |
| HORIZON THERAPEUTICS PUBLIC LIMITED COMPANY    | HORIZON THERAPEUTICS PLC                                                    | CUSIP: G46188101<br>LEI: 529900P0GSQ79OOZEV53 | Long             | EC               | CORP              | IE        |      7098 | NS      | $807752.40    | 1.64%             |  |  |  | No            |                  1 | On Loan: No      |
| TOTAL RETURN SWAP AGREEMENT BASED ON THE       | TOTAL RETURN SWAP AGREEMENT BASED ON THE DOW JONES U.S. BIOTECHNOLOGY INDEX | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |      2068 | OU      | $-1533.42     | -0.00%            |  |  |  | No            |                  2 | On Loan: No      |
| Beam Therapeutics Inc                          | BEAM THERAPEUTICS INC                                                       | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1854 | NS      | $72509.94     | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| NOVAVAX, INC.                                  | NOVAVAX INC                                                                 | CUSIP: 670002401<br>LEI: 529900J4GJHPEPQ23205 | Long             | EC               | CORP              | US        |      2459 | NS      | $25278.52     | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| EXACT SCIENCES CORPORATION                     | EXACT SCIENCES CORP                                                         | CUSIP: 30063P105<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |      5566 | NS      | $275572.66    | 0.56%             |  |  |  | No            |                  1 | On Loan: No      |
| BIOGEN INC.                                    | BIOGEN INC                                                                  | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |      4511 | NS      | $1249186.12   | 2.53%             |  |  |  | No            |                  1 | On Loan: No      |
| BIOMARIN PHARMACEUTICAL INC.                   | BIOMARIN PHARMACEUTICAL INC                                                 | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |      5821 | NS      | $602415.29    | 1.22%             |  |  |  | No            |                  1 | On Loan: No      |
| ARROWHEAD PHARMACEUTICALS, INC.                | ARROWHEAD PHARMACEUTICALS INC                                               | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |      3316 | NS      | $134496.96    | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| UMB FINANCIAL CORP                             | UMB FINANCIAL CORP                                                          | CUSIP: N/A<br>LEI: N/A                        | Long             | RA               | CORP              | US        |     57000 | PA      | $57000.00     | 0.12%             |  |  |  | No            |                  2 | On Loan: No      |
| METTLER-TOLEDO INTERNATIONAL INC.              | METTLER TOLEDO INTERNATIONAL INC                                            | CUSIP: 592688105<br>LEI: 5493000BD5GJNUDIUG10 | Long             | EC               | CORP              | US        |       698 | NS      | $1008924.10   | 2.04%             |  |  |  | No            |                  1 | On Loan: No      |
| AMGEN INC.                                     | AMGEN INC                                                                   | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |     16713 | NS      | $4389502.32   | 8.89%             |  |  |  | No            |                  1 | On Loan: No      |
| Biohaven Ltd                                   | BIOHAVEN LTD                                                                | CUSIP: G1110E107<br>LEI: N/A                  | Long             | EC               | CORP              | VG        |      2007 | NS      | $27857.16     | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Azenta, Inc.                                   | AZENTA INC                                                                  | CUSIP: 114340102<br>LEI: 35ZN6X1ANPH25YN32Y17 | Long             | EC               | CORP              | US        |      2350 | NS      | $136817.00    | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| ILLUMINA, INC.                                 | ILLUMINA INC                                                                | CUSIP: 452327109<br>LEI: SQ95QG8SR5Q56LSNF682 | Long             | EC               | CORP              | US        |      4927 | NS      | $996239.40    | 2.02%             |  |  |  | No            |                  1 | On Loan: No      |
| EXELIXIS, INC.                                 | EXELIXIS INC                                                                | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |     10104 | NS      | $162068.16    | 0.33%             |  |  |  | No            |                  1 | On Loan: No      |
| ALKERMES PUBLIC LIMITED COMPANY                | ALKERMES PLC                                                                | CUSIP: G01767105<br>LEI: N/A                  | Long             | EC               | CORP              | IE        |      5147 | NS      | $134491.11    | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| HSBC SECURITIES USA INC                        | HSBC SECURITIES USA INC                                                     | CUSIP: N/A<br>LEI: N/A                        | Long             | RA               | CORP              | US        |     88000 | PA      | $88000.00     | 0.18%             |  |  |  | No            |                  2 | On Loan: No      |
| SOCIETE GENERALE                               | SOCIETE GENERALE                                                            | CUSIP: N/A<br>LEI: N/A                        | Long             | RA               | CORP              | US        |    511000 | PA      | $511000.00    | 1.04%             |  |  |  | No            |                  2 | On Loan: No      |
| REPLIGEN CORPORATION                           | REPLIGEN CORP                                                               | CUSIP: 759916109<br>LEI: 54930006QJ0T5AUO1E71 | Long             | EC               | CORP              | US        |      1617 | NS      | $273774.27    | 0.55%             |  |  |  | No            |                  1 | On Loan: No      |
| FATE THERAPEUTICS, INC.                        | FATE THERAPEUTICS INC                                                       | CUSIP: 31189P102<br>LEI: 549300L14Q4UHOODLA90 | Long             | EC               | CORP              | US        |      2587 | NS      | $26102.83     | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| SOTERA HEALTH COMPANY                          | SOTERA HEALTH CO                                                            | CUSIP: 83601L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3093 | NS      | $25764.69     | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| VERTEX PHARMACEUTICALS INCORPORATED            | VERTEX PHARMACEUTICALS INC                                                  | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |      8040 | NS      | $2321791.20   | 4.70%             |  |  |  | No            |                  1 | On Loan: No      |
| GILEAD SCIENCES, INC.                          | GILEAD SCIENCES INC                                                         | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |     39287 | NS      | $3372788.95   | 6.83%             |  |  |  | No            |                  1 | On Loan: No      |
| IQVIA HOLDINGS INC                             | IQVIA HOLDINGS INC                                                          | CUSIP: 46266C105<br>LEI: 549300W3R20NM4KQPH86 | Long             | EC               | CORP              | US        |      5818 | NS      | $1192050.02   | 2.42%             |  |  |  | No            |                  1 | On Loan: No      |
| ABBVIE INC.                                    | ABBVIE INC                                                                  | CUSIP: 00287Y109<br>LEI: FR5LCKFTG8054YNNRU85 | Long             | EC               | CORP              | US        |     55394 | NS      | $8952224.34   | 18.14%            |  |  |  | No            |                  1 | On Loan: No      |
| AVANTOR, INC.                                  | AVANTOR INC                                                                 | CUSIP: 05352A100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     21118 | NS      | $445378.62    | 0.90%             |  |  |  | No            |                  1 | On Loan: No      |
| ALNYLAM PHARMACEUTICALS, INC.                  | ALNYLAM PHARMACEUTICALS INC                                                 | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |      3854 | NS      | $915903.10    | 1.86%             |  |  |  | No            |                  1 | On Loan: No      |
| INCYTE CORPORATION                             | INCYTE PHARMACEUTICALS INC                                                  | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |      5784 | NS      | $464570.88    | 0.94%             |  |  |  | No            |                  1 | On Loan: No      |
| Vir Biotechnology Inc                          | VIR BIOTECHNOLOGY INC                                                       | CUSIP: 92764N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2377 | NS      | $60161.87     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| HALOZYME THERAPEUTICS, INC.                    | HALOZYME THERAPEUTICS INC                                                   | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |      4235 | NS      | $240971.50    | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| WEST PHARMACEUTICAL SERVICES, INC.             | WEST PHARMACEUTICAL SERVICES INC                                            | CUSIP: 955306105<br>LEI: 5493007NKRGM1RJQ1P16 | Long             | EC               | CORP              | US        |      2319 | NS      | $545776.65    | 1.11%             |  |  |  | No            |                  1 | On Loan: No      |
| CRISPR Therapeutics AG                         | CRISPR THERAPEUTICS AG                                                      | CUSIP: H17182108<br>LEI: 506700O6IRRIQLT3W370 | Long             | EC               | CORP              | CH        |      2452 | NS      | $99673.80     | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2023-01-30

**Name of Applicant:** ProFunds

**Signature:** Denise Lewis

**Name of Signer:** Denise Lewis

**Title:** Treasurer and Principal Financial Officer