# EDGAR Filing Document

**Accession Number:** 0002056052
**File Stem:** 0002056052-26-000003
**Filing Date:** 2026-5
**Character Count:** 41174
**Document Hash:** f8ad73d5d7a87863036b13800edee7a0
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0002056052-26-000003.hdr.sgml**: 20260512

**ACCESSION NUMBER**: 0002056052-26-000003

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20260331

**FILED AS OF DATE**: 20260512

**DATE AS OF CHANGE**: 20260512

**EFFECTIVENESS DATE**: 20260512

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Persistent Asset Partners Ltd
- **CENTRAL INDEX KEY:** 0002056052

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** K3
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-25300
- **FILM NUMBER:** 26965708

**BUSINESS ADDRESS:**
- **STREET 1:** TWO EXCHANGE SQUARE, 8 CONNAUGHT PLACE
- **STREET 2:** SUITE 1901
- **CITY:** HONG KONG
- **STATE:** K3
- **ZIP:** 00000
- **BUSINESS PHONE:** 852 3793 3700

**MAIL ADDRESS:**
- **STREET 1:** TWO EXCHANGE SQUARE, 8 CONNAUGHT PLACE
- **STREET 2:** SUITE 1901
- **CITY:** HONG KONG
- **STATE:** K3
- **ZIP:** 00000

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 03-31-2026

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** Persistent Asset Partners Ltd<br>**Address:** TWO EXCHANGE SQUARE 8 CONNAUGHT PLACE<br>SUITE 1901<br>HONG KONG, K3 00000

**Form 13F File Number:** 028-25300

**CRD Number (if applicable):** 000177528

**SEC File Number (if applicable):** 802-89175

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Dawn Yu<br>**Title:** Responsible Officer<br>**Phone:** 852-3793-3913

**Signature, Place, and Date of Signing:**

Dawn Yu  Hong Kong, K3  05-12-2026<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 388

**Form 13F Information Table Value Total:** $268260531

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| ABBOTT LABORATORIES | COM | 002824100 |  | 696000 | 6779 | SH |  | SOLE |  | 6779 | 0 | 0 |
| ABBVIE INC | COM | 00287Y109 |  | 1332344 | 6126 | SH |  | SOLE |  | 6126 | 0 | 0 |
| ABIVAX SA | SPONSORED ADS | 00370M103 |  | 2137697 | 19198 | SH |  | SOLE |  | 19198 | 0 | 0 |
| ABIVAX SA | SPONSORED ADS | 00370M103 |  | 325320 | 253 | SH | Call | SOLE |  | 253 | 0 | 0 |
| ABIVAX SA | SPONSORED ADS | 00370M103 |  | 288425 | 253 | SH | Put | SOLE |  | 253 | 0 | 0 |
| ABIVAX SA | SPONSORED ADS | 00370M103 |  | 405314 | 3640 | SH |  | SOLE |  | 3640 | 0 | 0 |
| ADAGENE INC | ADS | 005329107 |  | 137694 | 35126 | SH |  | SOLE |  | 35126 | 0 | 0 |
| ADAPTIVE BIOTECHNOLOGIES COR | COM | 00650F109 |  | 92843 | 6689 | SH |  | SOLE |  | 6689 | 0 | 0 |
| ADLAI NORTYE LTD | SPONSORED ADS | 00704R109 |  | 233425 | 33732 | SH |  | SOLE |  | 33732 | 0 | 0 |
| AKAMAI TECHNOLOGIES INC | COM | 00971T101 |  | 841161 | 7324 | SH |  | SOLE |  | 7324 | 0 | 0 |
| ALKERMES PLC | SHS | G01767105 |  | 447021 | 12642 | SH |  | SOLE |  | 12642 | 0 | 0 |
| ALKERMES PLC | SHS | G01767105 |  | 456887 | 12921 | SH |  | SOLE |  | 12921 | 0 | 0 |
| ALLY FINL INC | COM | 02005N100 |  | 17390 | 94 | SH | Put | SOLE |  | 94 | 0 | 0 |
| ALPHABET INC | CAP STK CL C | 02079K107 |  | 2774510 | 9672 | SH |  | SOLE |  | 9672 | 0 | 0 |
| ALUMIS INC | COM | 022307102 |  | 179185 | 253 | SH | Call | SOLE |  | 253 | 0 | 0 |
| ALUMIS INC | COM | 022307102 |  | 6069 | 79 | SH | Put | SOLE |  | 79 | 0 | 0 |
| AMCOR PLC | COM NEW | G0250X149 |  | 1174175 | 29539 | SH |  | SOLE |  | 29539 | 0 | 0 |
| AMERANT BANCORP INC | CL A | 023576101 |  | 460063 | 20874 | SH |  | SOLE |  | 20874 | 0 | 0 |
| AMERIS BANCORP | COM | 03076K108 |  | 1094824 | 14038 | SH |  | SOLE |  | 14038 | 0 | 0 |
| AMNEAL PHARMACEUTICALS INC | COM STK CL A | 03168L105 |  | 221353 | 17808 | SH |  | SOLE |  | 17808 | 0 | 0 |
| AN2 THERAPEUTICS INC | COM | 037326105 |  | 130490 | 38155 | SH |  | SOLE |  | 38155 | 0 | 0 |
| ANAVEX LIFE SCIENCES CORP | COM NEW | 032797300 |  | 6 | 322 | SH | Call | SOLE |  | 322 | 0 | 0 |
| ANAVEX LIFE SCIENCES CORP | COM NEW | 032797300 |  | 406 | 828 | SH | Call | SOLE |  | 828 | 0 | 0 |
| ANNEXON INC | COM | 03589W102 |  | 186283 | 33625 | SH |  | SOLE |  | 33625 | 0 | 0 |
| ANNEXON INC | COM | 03589W102 |  | 12467 | 69 | SH | Call | SOLE |  | 69 | 0 | 0 |
| ANNEXON INC | COM | 03589W102 |  | 159567 | 536 | SH | Call | SOLE |  | 536 | 0 | 0 |
| ANNEXON INC | COM | 03589W102 |  | 73260 | 292 | SH | Call | SOLE |  | 292 | 0 | 0 |
| ANTERIS TECHNOLOGIES GLOBAL | COM | 03675P102 |  | 241802 | 43568 | SH |  | SOLE |  | 43568 | 0 | 0 |
| ANTERIS TECHNOLOGIES GLOBAL | COM | 03675P102 |  | 235015 | 42345 | SH |  | SOLE |  | 42345 | 0 | 0 |
| ANTERO RESOURCES CORP | COM | 03674X106 |  | 358307 | 8101 | SH |  | SOLE |  | 8101 | 0 | 0 |
| APOGEE THERAPEUTICS INC | COM | 03770N101 |  | 1934022 | 566 | SH | Call | SOLE |  | 566 | 0 | 0 |
| APOLLO GLOBAL MGMT INC | COM | 03769M106 |  | 67725 | 258 | SH | Call | SOLE |  | 258 | 0 | 0 |
| APOLLO GLOBAL MGMT INC | COM | 03769M106 |  | 7371 | 46 | SH | Call | SOLE |  | 46 | 0 | 0 |
| APPLE INC | COM | 037833100 |  | 23 | 1 | SH | Put | SOLE |  | 1 | 0 | 0 |
| APPLOVIN CORP | COM CL A | 03831W108 |  | 2020 | 1 | SH | Put | SOLE |  | 1 | 0 | 0 |
| ARBOR REALTY TRUST INC | COM | 038923108 |  | 154 | 335 | SH | Call | SOLE |  | 335 | 0 | 0 |
| ARCUS BIOSCIENCES INC | COM | 03969F109 |  | 1300385 | 60203 | SH |  | SOLE |  | 60203 | 0 | 0 |
| ARGENX SE | SPONSORED ADR | 04016X101 |  | 184753 | 253 | SH |  | SOLE |  | 253 | 0 | 0 |
| ARK ETF TR | INNOVATION ETF | 00214Q104 |  | 2610 | 49 | SH | Put | SOLE |  | 49 | 0 | 0 |
| ARRIVENT BIOPHARMA INC | COM | 04272N102 |  | 187052 | 8108 | SH |  | SOLE |  | 8108 | 0 | 0 |
| ARROWHEAD PHARMACEUTICALS IN | COM | 04280A100 |  | 166845 | 2661 | SH |  | SOLE |  | 2661 | 0 | 0 |
| ASCENDIS PHARMA A/S | SPONSORED ADR | 04351P101 |  | 27075 | 237 | SH | Call | SOLE |  | 237 | 0 | 0 |
| ASTERA LABS INC | COM | 04626A103 |  | 3673354 | 33516 | SH |  | SOLE |  | 33516 | 0 | 0 |
| ASTRAZENECA PLC | ORD | G0593M107 |  | 243764 | 1236 | SH |  | SOLE |  | 1236 | 0 | 0 |
| ATRIUM THERAPEUTICS INC | COM | 04965N104 |  | 3784 | 283 | SH |  | SOLE |  | 283 | 0 | 0 |
| ATYR PHARMA INC | COM NEW | 002120202 |  | 122 | 28 | SH | Call | SOLE |  | 28 | 0 | 0 |
| ATYR PHARMA INC | COM NEW | 002120202 |  | 4993 | 27 | SH | Put | SOLE |  | 27 | 0 | 0 |
| AVALO THERAPEUTICS INC | COM NEW | 05338F306 |  | 118216 | 7918 | SH |  | SOLE |  | 7918 | 0 | 0 |
| AXOS FINANCIAL INC | COM | 05465C100 |  | 1984809 | 23326 | SH |  | SOLE |  | 23326 | 0 | 0 |
| AXT INC | COM | 00246W103 |  | 13308420 | 233563 | SH |  | SOLE |  | 233563 | 0 | 0 |
| AYTU BIOPHARMA INC | COM | 054754858 |  | 253609 | 92897 | SH |  | SOLE |  | 92897 | 0 | 0 |
| BEACON FINANCIAL CORP. | COM | 084680107 |  | 280620 | 9354 | SH |  | SOLE |  | 9354 | 0 | 0 |
| BENITEC BIOPHARMA INC | COM NEW | 08205P209 |  | 194970 | 18307 | SH |  | SOLE |  | 18307 | 0 | 0 |
| BICYCLE THERAPEUTICS PLC | SPONSORED ADS | 088786108 |  | 558828 | 120437 | SH |  | SOLE |  | 120437 | 0 | 0 |
| BIOAGE LABS INC | COM | 09077V100 |  | 265271 | 15167 | SH |  | SOLE |  | 15167 | 0 | 0 |
| BIOGEN INC | COM | 09062X103 |  | 348877 | 1903 | SH |  | SOLE |  | 1903 | 0 | 0 |
| BIOHAVEN LTD | COM | G1110E107 |  | 132490 | 806 | SH | Call | SOLE |  | 806 | 0 | 0 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 |  | 2116793 | 37472 | SH |  | SOLE |  | 37472 | 0 | 0 |
| BITDEER TECHNOLOGIES GROUP | CL A ORD SHS | G11448100 |  | 803282 | 92865 | SH |  | SOLE |  | 92865 | 0 | 0 |
| BLOOM ENERGY CORP | COM CL A | 093712107 |  | 33195 | 245 | SH |  | SOLE |  | 245 | 0 | 0 |
| BRIDGEBIO PHARMA INC | COM | 10806X102 |  | 1599115 | 21534 | SH |  | SOLE |  | 21534 | 0 | 0 |
| BRIDGEBIO PHARMA INC | COM | 10806X102 |  | 169016 | 2276 | SH |  | SOLE |  | 2276 | 0 | 0 |
| BRIDGEBIO PHARMA INC | NOTE  1.750% 3/0 | 10806XAJ1 |  | 101757 | 60000 | PRN |  | SOLE |  | 60000 | 0 | 0 |
| BRIGHT MINDS BIOSCIENCES INC | COM NEW | 10919W405 |  | 168561 | 2310 | SH |  | SOLE |  | 2310 | 0 | 0 |
| CANADIAN SOLAR INC | COM | 136635109 |  | 692500 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 |  | 998962 | 831 | SH | Call | SOLE |  | 831 | 0 | 0 |
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 |  | 605963 | 19933 | SH |  | SOLE |  | 19933 | 0 | 0 |
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 |  | 157064 | 1045 | SH | Put | SOLE |  | 1045 | 0 | 0 |
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 |  | 7977 | 266 | SH | Put | SOLE |  | 266 | 0 | 0 |
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 |  | 23363 | 267 | SH | Put | SOLE |  | 267 | 0 | 0 |
| CARNIVAL CORP | COMMON STOCK | 143658300 |  | 378 | 54 | SH | Put | SOLE |  | 54 | 0 | 0 |
| CARVANA CO | CL A | 146869102 |  | 943140 | 3000 | SH |  | SOLE |  | 3000 | 0 | 0 |
| CELCUITY INC | COM | 15102K100 |  | 19350 | 45 | SH | Call | SOLE |  | 45 | 0 | 0 |
| CELCUITY INC | COM | 15102K100 |  | 153404 | 1344 | SH |  | SOLE |  | 1344 | 0 | 0 |
| CELCUITY INC | COM | 15102K100 |  | 399376 | 3499 | SH |  | SOLE |  | 3499 | 0 | 0 |
| CENCORA INC | COM | 03073E105 |  | 381994 | 1216 | SH |  | SOLE |  | 1216 | 0 | 0 |
| CERTARA INC | COM | 15687V109 |  | 163151 | 28623 | SH |  | SOLE |  | 28623 | 0 | 0 |
| CG ONCOLOGY INC | COM | 156944100 |  | 787728 | 11639 | SH |  | SOLE |  | 11639 | 0 | 0 |
| CHARLES RIV LABS INTL INC | COM | 159864107 |  | 455918 | 2643 | SH |  | SOLE |  | 2643 | 0 | 0 |
| CHEVRON CORPORATION | COM | 166764100 |  | 211 | 1 | SH |  | SOLE |  | 1 | 0 | 0 |
| CIENA CORP | COM NEW | 171779309 |  | 4595867 | 11838 | SH |  | SOLE |  | 11838 | 0 | 0 |
| CITIGROUP INC | COM NEW | 172967424 |  | 934385 | 8239 | SH |  | SOLE |  | 8239 | 0 | 0 |
| CLIMB BIO INC | COM | 28658R106 |  | 495426 | 72325 | SH |  | SOLE |  | 72325 | 0 | 0 |
| CMB.TECH NV | SHS | B38564108 |  | 999186 | 80385 | SH |  | SOLE |  | 80385 | 0 | 0 |
| CMB.TECH NV | SHS | B38564108 |  | 387223 | 30725 | SH |  | SOLE |  | 30725 | 0 | 0 |
| COASTAL FINL CORP WA | COM NEW | 19046P209 |  | 1877615 | 24673 | SH |  | SOLE |  | 24673 | 0 | 0 |
| COGENT BIOSCIENCES INC | COM | 19240Q201 |  | 3141400 | 81616 | SH |  | SOLE |  | 81616 | 0 | 0 |
| COGENT BIOSCIENCES INC | COM | 19240Q201 |  | 419541 | 10900 | SH |  | SOLE |  | 10900 | 0 | 0 |
| COHERENT CORP | COM | 19247G107 |  | 97904 | 411 | SH |  | SOLE |  | 411 | 0 | 0 |
| COHERENT CORP | COM | 19247G107 |  | 3174625 | 13327 | SH |  | SOLE |  | 13327 | 0 | 0 |
| COINBASE GLOBAL INC | COM CL A | 19260Q107 |  | 96625 | 47 | SH | Put | SOLE |  | 47 | 0 | 0 |
| COLUMBIA BKG SYS INC | COM | 197236102 |  | 1154693 | 42096 | SH |  | SOLE |  | 42096 | 0 | 0 |
| COMPASS PATHWAYS PLC | SPONSORED ADS | 20451W101 |  | 44572 | 8060 | SH |  | SOLE |  | 8060 | 0 | 0 |
| COMPASS THERAPEUTICS INC | COM | 20454B104 |  | 381901 | 72193 | SH |  | SOLE |  | 72193 | 0 | 0 |
| CONNECT BIOPHARMA HLDGS LTD | SHS | G23549101 |  | 132957 | 50747 | SH |  | SOLE |  | 50747 | 0 | 0 |
| CONNECTONE BANCORP INC | COM | 20786W107 |  | 313075 | 11695 | SH |  | SOLE |  | 11695 | 0 | 0 |
| CORBUS PHARMACEUTICALS HLDGS | COM NEW | 21833P301 |  | 85556 | 292 | SH | Call | SOLE |  | 292 | 0 | 0 |
| CORBUS PHARMACEUTICALS HLDGS | COM NEW | 21833P301 |  | 1044412 | 111226 | SH |  | SOLE |  | 111226 | 0 | 0 |
| CORCEPT THERAPEUTICS INC | COM | 218352102 |  | 3939 | 132 | SH | Call | SOLE |  | 132 | 0 | 0 |
| CORCEPT THERAPEUTICS INC | COM | 218352102 |  | 79939 | 269 | SH | Call | SOLE |  | 269 | 0 | 0 |
| CORCEPT THERAPEUTICS INC | COM | 218352102 |  | 101904 | 2528 | SH |  | SOLE |  | 2528 | 0 | 0 |
| COREWEAVE INC | COM CL A | 21873S108 |  | 224043 | 2892 | SH |  | SOLE |  | 2892 | 0 | 0 |
| COREWEAVE INC | COM CL A | 21873S108 |  | 354 | 12 | SH | Put | SOLE |  | 12 | 0 | 0 |
| COREWEAVE INC | COM CL A | 21873S108 |  | 897 | 13 | SH | Put | SOLE |  | 13 | 0 | 0 |
| CORMEDIX INC | COM | 21900C308 |  | 149634 | 427 | SH | Put | SOLE |  | 427 | 0 | 0 |
| CORNING INC | COM | 219350105 |  | 6744 | 7 | SH | Call | SOLE |  | 7 | 0 | 0 |
| CORNING INC | COM | 219350105 |  | 8034195 | 59088 | SH |  | SOLE |  | 59088 | 0 | 0 |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 |  | 11 | 270 | SH | Call | SOLE |  | 270 | 0 | 0 |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 |  | 907806 | 62051 | SH |  | SOLE |  | 62051 | 0 | 0 |
| CRH PLC | ORD | G25508105 |  | 1181864 | 11243 | SH |  | SOLE |  | 11243 | 0 | 0 |
| CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 |  | 2724 | 270 | SH | Call | SOLE |  | 270 | 0 | 0 |
| CUE BIOPHARMA INC | COM | 22978P106 |  | 7672 | 33369 | SH |  | SOLE |  | 33369 | 0 | 0 |
| CVB FINL CORP | COM | 126600105 |  | 1648635 | 85025 | SH |  | SOLE |  | 85025 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 111505 | 126 | SH | Call | SOLE |  | 126 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 84755 | 506 | SH | Put | SOLE |  | 506 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 85539 | 105 | SH | Call | SOLE |  | 105 | 0 | 0 |
| CYTOMX THERAPEUTICS INC. | COM | 23284F105 |  | 14018 | 801 | SH | Call | SOLE |  | 801 | 0 | 0 |
| DAMORA THERAPEUTICS INC | COM NEW | 36322Q206 |  | 138254 | 5338 | SH |  | SOLE |  | 5338 | 0 | 0 |
| DARLING INGREDIENTS INC | COM | 237266101 |  | 583053 | 9658 | SH |  | SOLE |  | 9658 | 0 | 0 |
| DBV TECHNOLOGIES S A | SPONSORED ADS | 23306J309 |  | 237979 | 11392 | SH |  | SOLE |  | 11392 | 0 | 0 |
| DEFINIUM THERAPEUTICS INC | COM SHS | 24477V105 |  | 299773 | 15861 | SH |  | SOLE |  | 15861 | 0 | 0 |
| DELL TECHNOLOGIES INC | CL C | 24703L202 |  | 12449 | 15 | SH | Call | SOLE |  | 15 | 0 | 0 |
| DEXCOM INC | COM | 252131107 |  | 301503 | 4801 | SH |  | SOLE |  | 4801 | 0 | 0 |
| DHT HOLDINGS INC | SHS NEW | Y2065G121 |  | 153212 | 8386 | SH |  | SOLE |  | 8386 | 0 | 0 |
| DIANTHUS THERAPEUTICS INC | COM | 252828108 |  | 212150 | 2528 | SH |  | SOLE |  | 2528 | 0 | 0 |
| DIANTHUS THERAPEUTICS INC | COM | 252828108 |  | 412383 | 4914 | SH |  | SOLE |  | 4914 | 0 | 0 |
| DIGITALOCEAN HLDGS INC | COM | 25402D102 |  | 10014 | 15 | SH | Call | SOLE |  | 15 | 0 | 0 |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 |  | 591008 | 539 | SH | Call | SOLE |  | 539 | 0 | 0 |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 |  | 316670 | 10053 | SH |  | SOLE |  | 10053 | 0 | 0 |
| EDWARDS LIFESCIENCES CORP | COM | 28176E108 |  | 553753 | 6915 | SH |  | SOLE |  | 6915 | 0 | 0 |
| ELDORADO GOLD CORP NEW | COM | 284902509 |  | 1793605 | 52246 | SH |  | SOLE |  | 52246 | 0 | 0 |
| ELI LILLY  CO | COM | 532457108 |  | 1395291 | 1517 | SH |  | SOLE |  | 1517 | 0 | 0 |
| ELI LILLY  CO | COM | 532457108 |  | 357791 | 389 | SH |  | SOLE |  | 389 | 0 | 0 |
| ENANTA PHARMACEUTICALS INC | COM | 29251M106 |  | 208711 | 16525 | SH |  | SOLE |  | 16525 | 0 | 0 |
| ENLIVEN THERAPEUTICS INC | COM | 29337E102 |  | 2430 | 62 | SH |  | SOLE |  | 62 | 0 | 0 |
| ENLIVEN THERAPEUTICS INC | COM | 29337E102 |  | 256525 | 6544 | SH |  | SOLE |  | 6544 | 0 | 0 |
| ENOVA INTL INC | COM | 29357K103 |  | 1322169 | 9734 | SH |  | SOLE |  | 9734 | 0 | 0 |
| ENTERA BIO LTD | SHS | M40527109 |  | 6528 | 5881 | SH |  | SOLE |  | 5881 | 0 | 0 |
| EQUILLIUM INC | COM | 29446K106 |  | 220234 | 110117 | SH |  | SOLE |  | 110117 | 0 | 0 |
| EQUINOX GOLD CORP | COM | 29446Y502 |  | 1731831 | 119767 | SH |  | SOLE |  | 119767 | 0 | 0 |
| ERASCA INC | COM | 29479A108 |  | 457409 | 28270 | SH |  | SOLE |  | 28270 | 0 | 0 |
| EUPRAXIA PHARMACEUTICALS INC | COM | 29842P105 |  | 73211 | 10112 | SH |  | SOLE |  | 10112 | 0 | 0 |
| EUPRAXIA PHARMACEUTICALS INC | COM | 29842P105 |  | 201373 | 27814 | SH |  | SOLE |  | 27814 | 0 | 0 |
| EVOLUS INC | COM | 30052C107 |  | 10 | 318 | SH | Call | SOLE |  | 318 | 0 | 0 |
| EXPAND ENERGY CORPORATION | COM | 165167735 |  | 1457432 | 13077 | SH |  | SOLE |  | 13077 | 0 | 0 |
| EYEPOINT INC | COM NEW | 30233G209 |  | 153959 | 269 | SH | Call | SOLE |  | 269 | 0 | 0 |
| EYEPOINT INC | COM NEW | 30233G209 |  | 581107 | 45082 | SH |  | SOLE |  | 45082 | 0 | 0 |
| EYEPOINT INC | COM NEW | 30233G209 |  | 179339 | 13913 | SH |  | SOLE |  | 13913 | 0 | 0 |
| FIGURE TECHNOLOGY SOLUTIO | COM CL A | 349381103 |  | 651467 | 19189 | SH |  | SOLE |  | 19189 | 0 | 0 |
| FIRST SOLAR INC | COM | 336433107 |  | 586607 | 3176 | SH |  | SOLE |  | 3176 | 0 | 0 |
| FIRST WESTN FINL INC | COM | 33751L105 |  | 848502 | 34520 | SH |  | SOLE |  | 34520 | 0 | 0 |
| FLUTTER ENTMT PLC | SHS | G3643J108 |  | 1201277 | 11783 | SH |  | SOLE |  | 11783 | 0 | 0 |
| FOGHORN THERAPEUTICS INC | COM | 344174107 |  | 97082 | 20310 | SH |  | SOLE |  | 20310 | 0 | 0 |
| FOGHORN THERAPEUTICS INC | COM | 344174107 |  | 125877 | 26334 | SH |  | SOLE |  | 26334 | 0 | 0 |
| FORTE BIOSCIENCES INC | COM NEW | 34962G208 |  | 174670 | 6744 | SH |  | SOLE |  | 6744 | 0 | 0 |
| FRONTLINE PLC | COM | M46528101 |  | 279200 | 8000 | SH |  | SOLE |  | 8000 | 0 | 0 |
| FRONTLINE PLC | COM | M46528101 |  | 200340 | 6000 | SH |  | SOLE |  | 6000 | 0 | 0 |
| FULL TRUCK ALLIANCE CO LTD | SPONSORED ADS | 35969L108 |  | 255731 | 30811 | SH |  | SOLE |  | 30811 | 0 | 0 |
| GALAXY DIGITAL INC. | CL A | 36317J209 |  | 9817 | 73 | SH | Put | SOLE |  | 73 | 0 | 0 |
| GE HEALTHCARE TECHNOLOGIES I | COMMON STOCK | 36266G107 |  | 159230 | 2237 | SH |  | SOLE |  | 2237 | 0 | 0 |
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 |  | 95524 | 6794 | SH |  | SOLE |  | 6794 | 0 | 0 |
| GUARDANT HEALTH INC | COM | 40131M109 |  | 377424 | 4086 | SH |  | SOLE |  | 4086 | 0 | 0 |
| HARMONY BIOSCIENCES HLDGS IN | COM | 413197104 |  | 659579 | 23548 | SH |  | SOLE |  | 23548 | 0 | 0 |
| HUMANA INC | COM | 444859102 |  | 289041 | 1667 | SH |  | SOLE |  | 1667 | 0 | 0 |
| HUYA INC | ADS REP SHS A | 44852D108 |  | 73501 | 22273 | SH |  | SOLE |  | 22273 | 0 | 0 |
| ICON PLC | SHS | G4705A100 |  | 377683 | 3413 | SH |  | SOLE |  | 3413 | 0 | 0 |
| IMMUNITYBIO INC | COM | 45256X103 |  | 98558 | 270 | SH | Put | SOLE |  | 270 | 0 | 0 |
| IMMUNOCORE HLDGS PLC | ADS | 45258D105 |  | 1476204 | 48962 | SH |  | SOLE |  | 48962 | 0 | 0 |
| INCYTE CORP | COM | 45337C102 |  | 1861882 | 19782 | SH |  | SOLE |  | 19782 | 0 | 0 |
| INCYTE CORP | COM | 45337C102 |  | 382093 | 266 | SH | Put | SOLE |  | 266 | 0 | 0 |
| INDIVIOR PHARMACEUTICALS INC | COM | 45579U109 |  | 549006 | 18012 | SH |  | SOLE |  | 18012 | 0 | 0 |
| INOVIO PHARMACEUTICALS INC | COM SHS | 45773H409 |  | 8550 | 190 | SH | Call | SOLE |  | 190 | 0 | 0 |
| INOVIO PHARMACEUTICALS INC | COM SHS | 45773H409 |  | 247365 | 142164 | SH |  | SOLE |  | 142164 | 0 | 0 |
| INTEL CORP | COM | 458140100 |  | 10957302 | 248296 | SH |  | SOLE |  | 248296 | 0 | 0 |
| INTEL CORP | COM | 458140100 |  | 1151484 | 26093 | SH |  | SOLE |  | 26093 | 0 | 0 |
| INTELLIA THERAPEUTICS INC | COM | 45826J105 |  | 632 | 540 | SH | Call | SOLE |  | 540 | 0 | 0 |
| INTERACTIVE BROKERS GROUP IN | COM CL A | 45841N107 |  | 643537 | 9595 | SH |  | SOLE |  | 9595 | 0 | 0 |
| INTERNATIONAL SEAWAYS INC | COM | Y41053102 |  | 451399 | 6364 | SH |  | SOLE |  | 6364 | 0 | 0 |
| INTUITIVE SURGICAL INC | COM NEW | 46120E602 |  | 450387 | 977 | SH |  | SOLE |  | 977 | 0 | 0 |
| INVENTIVA SA | ADS | 46124U107 |  | 493795 | 88972 | SH |  | SOLE |  | 88972 | 0 | 0 |
| INVENTIVA SA | ADS | 46124U107 |  | 217155 | 39127 | SH |  | SOLE |  | 39127 | 0 | 0 |
| INVIVYD INC | COM | 00534A102 |  | 72787 | 55990 | SH |  | SOLE |  | 55990 | 0 | 0 |
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 |  | 30047 | 758 | SH | Call | SOLE |  | 758 | 0 | 0 |
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 |  | 127 | 7 | SH | Put | SOLE |  | 7 | 0 | 0 |
| ISHARES BITCOIN TRUST ETF | SHS BEN INT | 46438F101 |  | 15649 | 122 | SH | Put | SOLE |  | 122 | 0 | 0 |
| ISHARES SILVER TR | ISHARES | 46428Q109 |  | 504 | 28 | SH | Put | SOLE |  | 28 | 0 | 0 |
| ISHARES TR | RUSSELL 2000 ETF | 464287655 |  | 196 | 23 | SH | Put | SOLE |  | 23 | 0 | 0 |
| JADE BIOSCIENCES INC | COM NEW | 008064206 |  | 344 | 88 | SH | Put | SOLE |  | 88 | 0 | 0 |
| JANUX THERAPEUTICS INC | COM | 47103J105 |  | 19035 | 80 | SH | Call | SOLE |  | 80 | 0 | 0 |
| JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 |  | 2616830 | 13842 | SH |  | SOLE |  | 13842 | 0 | 0 |
| JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 |  | 390010 | 2063 | SH |  | SOLE |  | 2063 | 0 | 0 |
| JEFFERSON CAPITAL INC | COM | 47248R103 |  | 341813 | 17775 | SH |  | SOLE |  | 17775 | 0 | 0 |
| JOHNSON  JOHNSON | COM | 478160104 |  | 3322673 | 13593 | SH |  | SOLE |  | 13593 | 0 | 0 |
| KALVISTA PHARMACEUTICALS INC | COM | 483497103 |  | 181190 | 9001 | SH |  | SOLE |  | 9001 | 0 | 0 |
| KANZHUN LIMITED | SPONSORED ADS | 48553T106 |  | 669500 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| KARYOPHARM THERAPEUTICS INC | COM NEW | 48576U205 |  | 94 | 253 | SH | Call | SOLE |  | 253 | 0 | 0 |
| KARYOPHARM THERAPEUTICS INC | COM NEW | 48576U205 |  | 1 | 88 | SH | Call | SOLE |  | 88 | 0 | 0 |
| KARYOPHARM THERAPEUTICS INC | COM NEW | 48576U205 |  | 2018 | 269 | SH | Call | SOLE |  | 269 | 0 | 0 |
| KKR  CO INC | COM | 48251W104 |  | 50399 | 140 | SH | Call | SOLE |  | 140 | 0 | 0 |
| KODIAK SCIENCES INC | COM | 50015M109 |  | 1844 | 1 | SH | Call | SOLE |  | 1 | 0 | 0 |
| KODIAK SCIENCES INC | COM | 50015M109 |  | 1859684 | 48785 | SH |  | SOLE |  | 48785 | 0 | 0 |
| KODIAK SCIENCES INC | COM | 50015M109 |  | 15813 | 253 | SH | Put | SOLE |  | 253 | 0 | 0 |
| KODIAK SCIENCES INC | COM | 50015M109 |  | 394688 | 372 | SH | Put | SOLE |  | 372 | 0 | 0 |
| KODIAK SCIENCES INC | COM | 50015M109 |  | 97244 | 2551 | SH |  | SOLE |  | 2551 | 0 | 0 |
| LANTHEUS HLDGS INC | COM | 516544103 |  | 200396 | 2642 | SH |  | SOLE |  | 2642 | 0 | 0 |
| LARIMAR THERAPEUTICS INC | COM | 517125100 |  | 189558 | 42124 | SH |  | SOLE |  | 42124 | 0 | 0 |
| LIPOCINE INC NEW | COM NEW | 53630X203 |  | 101010 | 12642 | SH |  | SOLE |  | 12642 | 0 | 0 |
| LIPOCINE INC NEW | COM NEW | 53630X203 |  | 6392 | 800 | SH |  | SOLE |  | 800 | 0 | 0 |
| LIQUIDIA CORPORATION | COM NEW | 53635D202 |  | 32830 | 198 | SH | Call | SOLE |  | 198 | 0 | 0 |
| LIQUIDIA CORPORATION | COM NEW | 53635D202 |  | 3850 | 9 | SH | Call | SOLE |  | 9 | 0 | 0 |
| LIQUIDIA CORPORATION | COM NEW | 53635D202 |  | 41060 | 118 | SH | Call | SOLE |  | 118 | 0 | 0 |
| LIQUIDIA CORPORATION | COM NEW | 53635D202 |  | 38049 | 603 | SH | Call | SOLE |  | 603 | 0 | 0 |
| LIQUIDIA CORPORATION | COM NEW | 53635D202 |  | 9986 | 263 | SH | Call | SOLE |  | 263 | 0 | 0 |
| LIQUIDIA CORPORATION | COM NEW | 53635D202 |  | 21665 | 134 | SH | Call | SOLE |  | 134 | 0 | 0 |
| LIQUIDIA CORPORATION | COM NEW | 53635D202 |  | 6125 | 350 | SH | Call | SOLE |  | 350 | 0 | 0 |
| LIQUIDIA CORPORATION | COM NEW | 53635D202 |  | 4181 | 126 | SH | Put | SOLE |  | 126 | 0 | 0 |
| LIVANOVA PLC | SHS | G5509L101 |  | 318054 | 5004 | SH |  | SOLE |  | 5004 | 0 | 0 |
| LIVE OAK BANCSHARES INC | COM | 53803X105 |  | 317307 | 9595 | SH |  | SOLE |  | 9595 | 0 | 0 |
| LUMENTUM HLDGS INC | COM | 55024U109 |  | 70276 | 100 | SH |  | SOLE |  | 100 | 0 | 0 |
| LUMENTUM HLDGS INC | COM | 55024U109 |  | 14457881 | 20573 | SH |  | SOLE |  | 20573 | 0 | 0 |
| LYELL IMMUNOPHARMA INC | COM NEW | 55083R203 |  | 26855 | 10 | SH | Put | SOLE |  | 10 | 0 | 0 |
| MACOM TECH SOLUTIONS HLDGS I | COM | 55405Y100 |  | 3485167 | 15694 | SH |  | SOLE |  | 15694 | 0 | 0 |
| MACROGENICS INC | COM | 556099109 |  | 438494 | 151728 | SH |  | SOLE |  | 151728 | 0 | 0 |
| MANNKIND CORP | COM NEW | 56400P706 |  | 116115 | 47394 | SH |  | SOLE |  | 47394 | 0 | 0 |
| MARVELL TECHNOLOGY INC | COM | 573874104 |  | 12049 | 22 | SH | Call | SOLE |  | 22 | 0 | 0 |
| MARVELL TECHNOLOGY INC | COM | 573874104 |  | 1454252 | 14682 | SH |  | SOLE |  | 14682 | 0 | 0 |
| MAZE THERAPEUTICS INC | COM | 578784100 |  | 113191 | 3792 | SH |  | SOLE |  | 3792 | 0 | 0 |
| MAZE THERAPEUTICS INC | COM | 578784100 |  | 148534 | 4976 | SH |  | SOLE |  | 4976 | 0 | 0 |
| MEDTRONIC PLC | SHS | G5960L103 |  | 281266 | 3246 | SH |  | SOLE |  | 3246 | 0 | 0 |
| MERCK  CO INC | COM | 58933Y105 |  | 12524 | 253 | SH | Put | SOLE |  | 253 | 0 | 0 |
| MICRON TECHNOLOGY INC | COM | 595112103 |  | 4921653 | 14568 | SH |  | SOLE |  | 14568 | 0 | 0 |
| MICRON TECHNOLOGY INC | COM | 595112103 |  | 669599 | 1982 | SH |  | SOLE |  | 1982 | 0 | 0 |
| MINERALYS THERAPEUTICS INC | COM | 603170101 |  | 181476 | 6699 | SH |  | SOLE |  | 6699 | 0 | 0 |
| MINERALYS THERAPEUTICS INC | COM | 603170101 |  | 235737 | 8702 | SH |  | SOLE |  | 8702 | 0 | 0 |
| MINISO GROUP HLDG LTD | SPONSORED ADS | 66981J102 |  | 559273 | 34523 | SH |  | SOLE |  | 34523 | 0 | 0 |
| MIRUM PHARMACEUTICALS INC | COM | 604749101 |  | 330720 | 3580 | SH |  | SOLE |  | 3580 | 0 | 0 |
| MKS INC. | COM | 55306N104 |  | 119501 | 520 | SH |  | SOLE |  | 520 | 0 | 0 |
| MODERNA INC | COM | 60770K107 |  | 3086 | 270 | SH | Put | SOLE |  | 270 | 0 | 0 |
| MODERNA INC | COM | 60770K107 |  | 4261 | 134 | SH | Put | SOLE |  | 134 | 0 | 0 |
| MODINE MFG CO | COM | 607828100 |  | 2748316 | 12682 | SH |  | SOLE |  | 12682 | 0 | 0 |
| MONOPAR THERAPEUTICS INC | COM NEW | 61023L207 |  | 22573 | 412 | SH |  | SOLE |  | 412 | 0 | 0 |
| MONOPAR THERAPEUTICS INC | COM NEW | 61023L207 |  | 20327 | 371 | SH |  | SOLE |  | 371 | 0 | 0 |
| MONTE ROSA THERAPEUTICS INC | COM | 61225M102 |  | 781375 | 47500 | SH |  | SOLE |  | 47500 | 0 | 0 |
| NEBIUS GROUP N.V. | SHS CLASS A | N97284108 |  | 1884904 | 18166 | SH |  | SOLE |  | 18166 | 0 | 0 |
| NEKTAR THERAPEUTICS | COM NEW | 640268306 |  | 418749 | 5820 | SH |  | SOLE |  | 5820 | 0 | 0 |
| NEW ORIENTAL ED  TECHNOLOGY | SPON ADR | 647581206 |  | 224028 | 3956 | SH |  | SOLE |  | 3956 | 0 | 0 |
| NEWS CORP NEW | CL B | 65249B208 |  | 960103 | 33676 | SH |  | SOLE |  | 33676 | 0 | 0 |
| NEXGEN ENERGY LTD | COM | 65340P106 |  | 2756153 | 237953 | SH |  | SOLE |  | 237953 | 0 | 0 |
| NORTHEAST BK PORTLAND ME | COM | 66405S100 |  | 846034 | 7529 | SH |  | SOLE |  | 7529 | 0 | 0 |
| NORTHPOINTE BANCSHARES INC. | COM SHS | 66661N886 |  | 688243 | 39875 | SH |  | SOLE |  | 39875 | 0 | 0 |
| NOVO-NORDISK A S | ADR | 670100205 |  | 135424 | 3685 | SH |  | SOLE |  | 3685 | 0 | 0 |
| NOVO-NORDISK A S | ADR | 670100205 |  | 338756 | 143 | SH | Put | SOLE |  | 143 | 0 | 0 |
| NU HLDGS LTD | ORD SHS CL A | G6683N103 |  | 965147 | 67164 | SH |  | SOLE |  | 67164 | 0 | 0 |
| NVIDIA CORPORATION | COM | 67066G104 |  | 6964838 | 39936 | SH |  | SOLE |  | 39936 | 0 | 0 |
| OCUGEN INC | COM | 67577C105 |  | 18336 | 758 | SH | Call | SOLE |  | 758 | 0 | 0 |
| OCUGEN INC | COM | 67577C105 |  | 91512 | 50559 | SH |  | SOLE |  | 50559 | 0 | 0 |
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 |  | 104 | 12 | SH | Call | SOLE |  | 12 | 0 | 0 |
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 |  | 947 | 165 | SH | Call | SOLE |  | 165 | 0 | 0 |
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 |  | 4 | 1 | SH | Call | SOLE |  | 1 | 0 | 0 |
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 |  | 95 | 33 | SH | Call | SOLE |  | 33 | 0 | 0 |
| OPUS GENETICS INC | COM | 67577R102 |  | 81531 | 17919 | SH |  | SOLE |  | 17919 | 0 | 0 |
| PALISADE BIO INC | COM | 696389402 |  | 413609 | 236348 | SH |  | SOLE |  | 236348 | 0 | 0 |
| PASITHEA THERAPEUTICS CORP | COM NEW | 70261F202 |  | 215534 | 290555 | SH |  | SOLE |  | 290555 | 0 | 0 |
| PASSAGE BIO INC | COM NEW | 702712209 |  | 38897 | 4955 | SH |  | SOLE |  | 4955 | 0 | 0 |
| PATHWARD FINANCIAL INC | COM | 59100U108 |  | 834657 | 9354 | SH |  | SOLE |  | 9354 | 0 | 0 |
| PBF ENERGY INC | CL A | 69318G106 |  | 322761 | 6418 | SH |  | SOLE |  | 6418 | 0 | 0 |
| PDD HOLDINGS INC | SPONSORED ADS | 722304102 |  | 927488 | 9077 | SH |  | SOLE |  | 9077 | 0 | 0 |
| PDD HOLDINGS INC | SPONSORED ADS | 722304102 |  | 577828 | 5655 | SH |  | SOLE |  | 5655 | 0 | 0 |
| PELTHOS THERAPEUTICS INC | COM SHS | 171126204 |  | 126207 | 6007 | SH |  | SOLE |  | 6007 | 0 | 0 |
| PEPGEN INC | COM | 713317105 |  | 67529 | 38152 | SH |  | SOLE |  | 38152 | 0 | 0 |
| PERSONALIS INC | COM | 71535D106 |  | 133318 | 20929 | SH |  | SOLE |  | 20929 | 0 | 0 |
| PHARVARIS N V | COM | N69605108 |  | 223288 | 7904 | SH |  | SOLE |  | 7904 | 0 | 0 |
| PHATHOM PHARMACEUTICALS INC | COM | 71722W107 |  | 153796 | 13843 | SH |  | SOLE |  | 13843 | 0 | 0 |
| PHATHOM PHARMACEUTICALS INC | COM | 71722W107 |  | 143575 | 12923 | SH |  | SOLE |  | 12923 | 0 | 0 |
| POWER SOLUTIONS INTL INC | COM NEW | 73933G202 |  | 261480 | 4295 | SH |  | SOLE |  | 4295 | 0 | 0 |
| PRAXIS PRECISION MEDICINES I | COM NEW | 74006W207 |  | 364397 | 1131 | SH |  | SOLE |  | 1131 | 0 | 0 |
| PRECIGEN INC | COM | 74017N105 |  | 54095 | 13978 | SH |  | SOLE |  | 13978 | 0 | 0 |
| PROQR THRAPEUTICS N V | SHS EURO | N71542109 |  | 74629 | 46067 | SH |  | SOLE |  | 46067 | 0 | 0 |
| PURETECH HEALTH PLC | ADS | 746237106 |  | 26139 | 1759 | SH |  | SOLE |  | 1759 | 0 | 0 |
| QCR HLDGS INC | COM | 74727A104 |  | 999167 | 11693 | SH |  | SOLE |  | 11693 | 0 | 0 |
| QNITY ELECTRONICS INC | COMMON STOCK | 74743L100 |  | 590053 | 5114 | SH |  | SOLE |  | 5114 | 0 | 0 |
| QORVO INC | COM | 74736K101 |  | 2329430 | 30096 | SH |  | SOLE |  | 30096 | 0 | 0 |
| RANGE RES CORP | COM | 75281A109 |  | 542228 | 11734 | SH |  | SOLE |  | 11734 | 0 | 0 |
| REGENERON PHARMACEUTICALS | COM | 75886F107 |  | 309056 | 400 | SH |  | SOLE |  | 400 | 0 | 0 |
| RELAY THERAPEUTICS INC | COM | 75943R102 |  | 162762 | 16358 | SH |  | SOLE |  | 16358 | 0 | 0 |
| RELMADA THERAPEUTICS INC | COM | 75955J402 |  | 353380 | 50773 | SH |  | SOLE |  | 50773 | 0 | 0 |
| REPLIMUNE GROUP INC | COM | 76029N106 |  | 92117 | 506 | SH | Call | SOLE |  | 506 | 0 | 0 |
| REPLIMUNE GROUP INC | COM | 76029N106 |  | 1937 | 14 | SH | Call | SOLE |  | 14 | 0 | 0 |
| REPLIMUNE GROUP INC | COM | 76029N106 |  | 101922 | 617 | SH | Put | SOLE |  | 617 | 0 | 0 |
| REPLIMUNE GROUP INC | COM | 76029N106 |  | 135546 | 623 | SH | Put | SOLE |  | 623 | 0 | 0 |
| REPLIMUNE GROUP INC | COM | 76029N106 |  | 194654 | 25445 | SH |  | SOLE |  | 25445 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 35102 | 156 | SH | Put | SOLE |  | 156 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 18467 | 35 | SH | Put | SOLE |  | 35 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 36947 | 126 | SH | Put | SOLE |  | 126 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 1999460 | 20560 | SH |  | SOLE |  | 20560 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 533222 | 5483 | SH |  | SOLE |  | 5483 | 0 | 0 |
| ROBLOX CORP | CL A | 771049103 |  | 991440 | 17529 | SH |  | SOLE |  | 17529 | 0 | 0 |
| ROCKET COS INC | COM CL A | 77311W101 |  | 30947 | 326 | SH | Call | SOLE |  | 326 | 0 | 0 |
| ROCKET COS INC | COM CL A | 77311W101 |  | 920735 | 64613 | SH |  | SOLE |  | 64613 | 0 | 0 |
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 |  | 27677 | 7731 | SH |  | SOLE |  | 7731 | 0 | 0 |
| ROIVANT SCIENCES LTD | SHS | G76279101 |  | 11068 | 860 | SH | Put | SOLE |  | 860 | 0 | 0 |
| ROYALTY PHARMA PLC | SHS CLASS A | G7709Q104 |  | 248389 | 5178 | SH |  | SOLE |  | 5178 | 0 | 0 |
| RUBRIK INC. | CL A | 781154109 |  | 489700 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| SAB BIOTHERAPEUTICS INC | COM NEW | 78397T202 |  | 267074 | 69732 | SH |  | SOLE |  | 69732 | 0 | 0 |
| SAILPOINT INC | COM | 78781J109 |  | 1577692 | 119161 | SH |  | SOLE |  | 119161 | 0 | 0 |
| SANDISK CORP | COM | 80004C200 |  | 1972 | 2 | SH | Put | SOLE |  | 2 | 0 | 0 |
| SANDISK CORP | COM | 80004C200 |  | 119444 | 188 | SH |  | SOLE |  | 188 | 0 | 0 |
| SANDISK CORP | COM | 80004C200 |  | 8953211 | 14092 | SH |  | SOLE |  | 14092 | 0 | 0 |
| SANOFI SA | SPONSORED ADR | 80105N105 |  | 479198 | 9946 | SH |  | SOLE |  | 9946 | 0 | 0 |
| SEA LTD | SPONSORD ADS | 81141R100 |  | 248430 | 3000 | SH |  | SOLE |  | 3000 | 0 | 0 |
| SEADRILL LTD | COM | G7997W102 |  | 222997 | 4961 | SH |  | SOLE |  | 4961 | 0 | 0 |
| SELLAS LIFE SCIENCES GROUP I | COM NEW | 81642T209 |  | 52734 | 758 | SH | Call | SOLE |  | 758 | 0 | 0 |
| SEMTECH CORP | COM | 816850101 |  | 2410886 | 31355 | SH |  | SOLE |  | 31355 | 0 | 0 |
| SERVISFIRST BANCSHARES INC | COM | 81768T108 |  | 1208905 | 16599 | SH |  | SOLE |  | 16599 | 0 | 0 |
| SHATTUCK LABS INC | COM | 82024L103 |  | 477292 | 74229 | SH |  | SOLE |  | 74229 | 0 | 0 |
| SIMILARWEB LTD | SHS | M84137104 |  | 469800 | 180000 | SH |  | SOLE |  | 180000 | 0 | 0 |
| SLB LIMITED | COM STK | 806857108 |  | 103060 | 2000 | SH |  | SOLE |  | 2000 | 0 | 0 |
| SOLARIS RES INC | COM NEW | 83419D201 |  | 137523 | 15956 | SH |  | SOLE |  | 15956 | 0 | 0 |
| SOLID BIOSCIENCES INC | COM NEW | 83422E204 |  | 201528 | 27990 | SH |  | SOLE |  | 27990 | 0 | 0 |
| SOUTHSTATE BK CORP | COM | 84472E102 |  | 887729 | 9595 | SH |  | SOLE |  | 9595 | 0 | 0 |
| SPROTT INC | COM NEW | 852066208 |  | 959431 | 6714 | SH |  | SOLE |  | 6714 | 0 | 0 |
| SPRUCE BIOSCIENCES INC | COM NEW | 85209E208 |  | 165205 | 2528 | SH |  | SOLE |  | 2528 | 0 | 0 |
| SPYRE THERAPEUTICS INC | COM NEW | 00773J202 |  | 242263 | 4803 | SH |  | SOLE |  | 4803 | 0 | 0 |
| STIFEL FINL CORP | COM | 860630102 |  | 886596 | 11994 | SH |  | SOLE |  | 11994 | 0 | 0 |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 |  | 22871 | 253 | SH | Put | SOLE |  | 253 | 0 | 0 |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 |  | 19713 | 70 | SH | Put | SOLE |  | 70 | 0 | 0 |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 |  | 880277 | 18263 | SH |  | SOLE |  | 18263 | 0 | 0 |
| STRYKER CORPORATION | COM | 863667101 |  | 364735 | 1110 | SH |  | SOLE |  | 1110 | 0 | 0 |
| SUPER MICRO COMPUTER INC | COM NEW | 86800U302 |  | 4150 | 83 | SH | Put | SOLE |  | 83 | 0 | 0 |
| SURROZEN INC | COM NEW | 86889P208 |  | 208076 | 7143 | SH |  | SOLE |  | 7143 | 0 | 0 |
| SUTRO BIOPHARMA INC | COM SHS | 869367201 |  | 184608 | 7411 | SH |  | SOLE |  | 7411 | 0 | 0 |
| TAIWAN SEMICONDUCTOR MANUFAC | SPONSORED ADS | 874039100 |  | 4219644 | 12486 | SH |  | SOLE |  | 12486 | 0 | 0 |
| TALPHERA INC | COM NEW | 00444T209 |  | 29105 | 38968 | SH |  | SOLE |  | 38968 | 0 | 0 |
| TANGO THERAPEUTICS INC | COM | 87583X109 |  | 483587 | 23116 | SH |  | SOLE |  | 23116 | 0 | 0 |
| TARSUS PHARMACEUTICALS INC | COM | 87650L103 |  | 459903 | 6556 | SH |  | SOLE |  | 6556 | 0 | 0 |
| TASEKO MINES LTD | COM | 876511106 |  | 1480952 | 229605 | SH |  | SOLE |  | 229605 | 0 | 0 |
| TE CONNECTIVITY PLC | ORD SHS | G87052109 |  | 2825950 | 13520 | SH |  | SOLE |  | 13520 | 0 | 0 |
| TENAX THERAPEUTICS INC | COM NEW | 88032L605 |  | 726793 | 45453 | SH |  | SOLE |  | 45453 | 0 | 0 |
| TENAX THERAPEUTICS INC | COM NEW | 88032L605 |  | 203537 | 12729 | SH |  | SOLE |  | 12729 | 0 | 0 |
| TERADYNE INC | COM | 880770102 |  | 3306122 | 11152 | SH |  | SOLE |  | 11152 | 0 | 0 |
| TERNS PHARMACEUTICALS INC | COM | 880881107 |  | 2422642 | 45953 | SH |  | SOLE |  | 45953 | 0 | 0 |
| TESLA INC | COM | 88160R101 |  | 1071755 | 2883 | SH |  | SOLE |  | 2883 | 0 | 0 |
| TG THERAPEUTICS INC | COM | 88322Q108 |  | 1763318 | 53080 | SH |  | SOLE |  | 53080 | 0 | 0 |
| THERMO FISHER SCIENTIFIC INC | COM | 883556102 |  | 247240 | 503 | SH |  | SOLE |  | 503 | 0 | 0 |
| TOWER SEMICONDUCTOR LTD | SHS NEW | M87915274 |  | 11863852 | 67608 | SH |  | SOLE |  | 67608 | 0 | 0 |
| TREVI THERAPEUTICS INC | COM | 89532M101 |  | 65329 | 5476 | SH |  | SOLE |  | 5476 | 0 | 0 |
| TREVI THERAPEUTICS INC | COM | 89532M101 |  | 267673 | 22437 | SH |  | SOLE |  | 22437 | 0 | 0 |
| TRIPADVISOR INC | COM | 896945201 |  | 1066000 | 100000 | SH |  | SOLE |  | 100000 | 0 | 0 |
| TRIUMPH FINANCIAL INC | COM | 89679E300 |  | 846754 | 14193 | SH |  | SOLE |  | 14193 | 0 | 0 |
| TYRA BIOSCIENCES INC | COM | 90240B106 |  | 173039 | 4518 | SH |  | SOLE |  | 4518 | 0 | 0 |
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 |  | 186120 | 8884 | SH |  | SOLE |  | 8884 | 0 | 0 |
| UMB FINL CORP | COM | 902788108 |  | 324722 | 2879 | SH |  | SOLE |  | 2879 | 0 | 0 |
| UNICYCIVE THERAPEUTICS INC | COM NEW | 90466Y202 |  | 176522 | 26827 | SH |  | SOLE |  | 26827 | 0 | 0 |
| UNIQURE NV | SHS | N90064101 |  | 2408 | 134 | SH | Call | SOLE |  | 134 | 0 | 0 |
| UNIQURE NV | SHS | N90064101 |  | 111988 | 506 | SH | Call | SOLE |  | 506 | 0 | 0 |
| UNIQURE NV | SHS | N90064101 |  | 79440 | 229 | SH | Put | SOLE |  | 229 | 0 | 0 |
| UNIQURE NV | SHS | N90064101 |  | 265752 | 459 | SH | Put | SOLE |  | 459 | 0 | 0 |
| UNIQURE NV | SHS | N90064101 |  | 128952 | 7887 | SH |  | SOLE |  | 7887 | 0 | 0 |
| UNITED THERAPEUTICS CORP DEL | COM | 91307C102 |  | 125964 | 39 | SH | Call | SOLE |  | 39 | 0 | 0 |
| UNITED THERAPEUTICS CORP DEL | COM | 91307C102 |  | 15136 | 63 | SH | Call | SOLE |  | 63 | 0 | 0 |
| UNITED THERAPEUTICS CORP DEL | COM | 91307C102 |  | 5619 | 51 | SH | Put | SOLE |  | 51 | 0 | 0 |
| UNITED THERAPEUTICS CORP DEL | COM | 91307C102 |  | 4092748 | 6902 | SH |  | SOLE |  | 6902 | 0 | 0 |
| UPSTART HLDGS INC | COM | 91680M107 |  | 36002 | 188 | SH | Call | SOLE |  | 188 | 0 | 0 |
| UPSTREAM BIO INC | COM | 91678A107 |  | 49455 | 5495 | SH |  | SOLE |  | 5495 | 0 | 0 |
| UROGEN PHARMA LTD | COM | M96088105 |  | 104716 | 5824 | SH |  | SOLE |  | 5824 | 0 | 0 |
| VAXCYTE INC | COM | 92243G108 |  | 323314 | 135 | SH | Call | SOLE |  | 135 | 0 | 0 |
| VAXCYTE INC | COM | 92243G108 |  | 309087 | 5319 | SH |  | SOLE |  | 5319 | 0 | 0 |
| VENTURE GLOBAL INC | COM CL A | 92333F101 |  | 338 | 27 | SH | Call | SOLE |  | 27 | 0 | 0 |
| VERADERMICS INC | COMMON STOCK | 922967104 |  | 580412 | 9191 | SH |  | SOLE |  | 9191 | 0 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 |  | 41215 | 236 | SH | Call | SOLE |  | 236 | 0 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 |  | 419301 | 939 | SH |  | SOLE |  | 939 | 0 | 0 |
| VIKING THERAPEUTICS INC | COM | 92686J106 |  | 23480 | 15 | SH | Call | SOLE |  | 15 | 0 | 0 |
| VIKING THERAPEUTICS INC | COM | 92686J106 |  | 318790 | 369 | SH | Call | SOLE |  | 369 | 0 | 0 |
| VIKING THERAPEUTICS INC | COM | 92686J106 |  | 808193 | 561 | SH | Call | SOLE |  | 561 | 0 | 0 |
| VIKING THERAPEUTICS INC | COM | 92686J106 |  | 72766 | 99 | SH | Call | SOLE |  | 99 | 0 | 0 |
| VIKING THERAPEUTICS INC | COM | 92686J106 |  | 202922 | 537 | SH | Call | SOLE |  | 537 | 0 | 0 |
| VIKING THERAPEUTICS INC | COM | 92686J106 |  | 94640 | 91 | SH | Call | SOLE |  | 91 | 0 | 0 |
| VIKING THERAPEUTICS INC | COM | 92686J106 |  | 4329968 | 133066 | SH |  | SOLE |  | 133066 | 0 | 0 |
| VIR BIOTECHNOLOGY INC | COM | 92764N102 |  | 68515 | 225 | SH | Call | SOLE |  | 225 | 0 | 0 |
| VISTAGEN THERAPEUTICS INC | COM | 92840H400 |  | 15209 | 26612 | SH |  | SOLE |  | 26612 | 0 | 0 |
| VOYAGER THERAPEUTICS INC | COM | 92915B106 |  | 48523 | 379 | SH | Call | SOLE |  | 379 | 0 | 0 |
| VOYAGER THERAPEUTICS INC | COM | 92915B106 |  | 413383 | 107094 | SH |  | SOLE |  | 107094 | 0 | 0 |
| WELLS FARGO  CO | COM | 949746101 |  | 1205 | 33 | SH | Put | SOLE |  | 33 | 0 | 0 |
| XERIS BIOPHARMA HOLDINGS INC | COM | 98422E103 |  | 206834 | 35661 | SH |  | SOLE |  | 35661 | 0 | 0 |
| YATSEN HLDG LTD | SPONSORED ADS | 985194208 |  | 62065 | 20151 | SH |  | SOLE |  | 20151 | 0 | 0 |
| ZAI LAB LTD | ADR | 98887Q104 |  | 232097 | 12339 | SH |  | SOLE |  | 12339 | 0 | 0 |
| ZILLOW GROUP INC | CL C CAP STK | 98954M200 |  | 275467 | 6657 | SH |  | SOLE |  | 6657 | 0 | 0 |
| ZYMEWORKS INC | COM | 98985Y108 |  | 899812 | 35935 | SH |  | SOLE |  | 35935 | 0 | 0 |

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