# EDGAR Filing Document

**Accession Number:** 0001378872
**File Stem:** 0001378872-26-000841
**Filing Date:** 2026-4
**Character Count:** 97253
**Document Hash:** 56d943cd1fb3c28fea28177b1c7fa29e
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001378872-26-000841.hdr.sgml**: 20260428

**ACCESSION NUMBER**: 0001378872-26-000841

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20260228

**FILED AS OF DATE**: 20260428

**DATE AS OF CHANGE**: 20260428

**PERIOD START**: 20260831

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Invesco Exchange-Traded Fund Trust II
- **CENTRAL INDEX KEY:** 0001378872

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **FISCAL YEAR END:** 1031

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-21977
- **FILM NUMBER:** 26906767

**BUSINESS ADDRESS:**
- **STREET 1:** 3500 LACEY ROAD
- **STREET 2:** SUITE 700
- **CITY:** DOWNERS GROVE
- **STATE:** IL
- **ZIP:** 60515
- **BUSINESS PHONE:** 800-983-0903

**MAIL ADDRESS:**
- **STREET 1:** 3500 LACEY ROAD
- **STREET 2:** SUITE 700
- **CITY:** DOWNERS GROVE
- **STATE:** IL
- **ZIP:** 60515

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** PowerShares Exchange-Traded Fund Trust II
- **DATE OF NAME CHANGE:** 20070919

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** PowerShares Global Exchange-Traded Fund Trust
- **DATE OF NAME CHANGE:** 20061023

## Series and Classes Contracts Data

### Invesco Nasdaq Biotechnology ETF (Series ID: S000072469)

| Class ID   | Class Name                       | Ticker Symbol   |
|:---|:---|:---|
| C000228754 | Invesco Nasdaq Biotechnology ETF | IBBQ            |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** Invesco Exchange-Traded Fund Trust II

- **b. Investment Company Act file number:** 811-21977

- **c. CIK number of Registrant:** 0001378872

- **d. LEI of Registrant:** O540V2L4S174Y60FMD36

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 3500 Lacey Road

  - **City:** Downers Grove

  - **State:** IL

  - **Foreign country:** US

  - **Zip / Postal Code:** 60515

  - **Telephone number:** 800-983-0903

**Item A.2. Information about the Series.**

- **a. Name of Series:** Invesco Nasdaq Biotechnology ETF

- **b. EDGAR series identifier (if any):** S000072469

- **c. LEI of Series:** 549300GYFD12WC2CZH57

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2026-08-31

- **b. Date as of which information is reported:** 2026-02-28

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $90780456.21

**Total Liabilities:** $15037968.84

**Net Assets:** $75742487.37

**Cash Not Reported:** $8460.85

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000228754 | -1.86%               | 2.54%                | 3.30%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $-1544417.63             | $382296.33                                 |
| Month 2  | $2460934.19              | $-866510.20                                |
| Month 3  | $901687.31               | $1458039.83                                |

### Schedule of Portfolio Investments

| Name                                       | Title                                                      | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Anavex Life Sciences Corp.                 | Anavex Life Sciences Corp.                                 | CUSIP: 032797300<br>LEI: 549300K1I5L8COCQ8W36 | Long             | EC               | CORP              | US        |      4989 | NS      | $22101.27     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Kura Oncology, Inc.                        | Kura Oncology, Inc.                                        | CUSIP: 50127T109<br>LEI: 5493005QORQTZCZYOP39 | Long             | EC               | CORP              | US        |      4878 | NS      | $42584.94     | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Voyager Therapeutics, Inc.                 | Voyager Therapeutics, Inc.                                 | CUSIP: 92915B106<br>LEI: 54930082S4XVR0ZWCC74 | Long             | EC               | CORP              | US        |      3162 | NS      | $12964.20     | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| NovoCure Ltd.                              | NovoCure Ltd.                                              | CUSIP: G6674U108<br>LEI: 213800YPP55UMHWA4826 | Long             | EC               | CORP              | JE        |      6261 | NS      | $85587.87     | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| Ionis Pharmaceuticals, Inc.                | Ionis Pharmaceuticals, Inc.                                | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |      9163 | NS      | $743577.45    | 0.98%             |  |  |  | No            |                  1 | On Loan: No      |
| Axsome Therapeutics, Inc.                  | Axsome Therapeutics, Inc.                                  | CUSIP: 05464T104<br>LEI: 549300EXGR0XLRJEIB95 | Long             | EC               | CORP              | US        |      2849 | NS      | $466922.61    | 0.62%             |  |  |  | No            |                  1 | On Loan: No      |
| Innoviva, Inc.                             | Innoviva, Inc.                                             | CUSIP: 45781M101<br>LEI: 549300ACOX4QTBES6535 | Long             | EC               | CORP              | US        |      4181 | NS      | $95995.76     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| BeOne Medicines Ltd.                       | BeOne Medicines Ltd., ADR                                  | CUSIP: 07725L102<br>LEI: 549300JFUK6FRD5MH739 | Long             | EC               | CORP              | CH        |      1784 | NS      | $565510.16    | 0.75%             |  |  |  | No            |                  1 | On Loan: No      |
| Editas Medicine, Inc.                      | Editas Medicine, Inc.                                      | CUSIP: 28106W103<br>LEI: 5299000AON4Q9NT2JE42 | Long             | EC               | CORP              | US        |      5197 | NS      | $11433.40     | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Syndax Pharmaceuticals, Inc.               | Syndax Pharmaceuticals, Inc.                               | CUSIP: 87164F105<br>LEI: 529900OF94TRHKZVBS87 | Long             | EC               | CORP              | US        |      4873 | NS      | $105792.83    | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Corvus Pharmaceuticals, Inc.               | Corvus Pharmaceuticals, Inc.                               | CUSIP: 221015100<br>LEI: 549300I3AVJ8F75NCX65 | Long             | EC               | CORP              | US        |      4177 | NS      | $76272.02     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Arrowhead Pharmaceuticals, Inc.            | Arrowhead Pharmaceuticals, Inc.                            | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |      7676 | NS      | $485660.52    | 0.64%             |  |  |  | No            |                  1 | On Loan: No      |
| Intellia Therapeutics, Inc.                | Intellia Therapeutics, Inc.                                | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |      6453 | NS      | $88922.34     | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Wave Life Sciences Ltd.                    | Wave Life Sciences Ltd.                                    | CUSIP: Y95308105<br>LEI: 54930070006GPKFYZ813 | Long             | EC               | CORP              | SG        |      9352 | NS      | $130273.36    | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Madrigal Pharmaceuticals, Inc.             | Madrigal Pharmaceuticals, Inc.                             | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |      1287 | NS      | $555984.00    | 0.73%             |  |  |  | No            |                  1 | On Loan: —       |
| Medpace Holdings, Inc.                     | Medpace Holdings, Inc.                                     | CUSIP: 58506Q109<br>LEI: 549300H8TYEUVTW14A54 | Long             | EC               | CORP              | US        |      1593 | NS      | $719653.68    | 0.95%             |  |  |  | No            |                  1 | On Loan: No      |
| Protagonist Therapeutics, Inc.             | Protagonist Therapeutics, Inc.                             | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3560 | NS      | $327804.80    | 0.43%             |  |  |  | No            |                  1 | On Loan: —       |
| AC Immune S.A.                             | AC Immune S.A.                                             | CUSIP: H00263105<br>LEI: 967600VLQ0ZC2HSOG765 | Long             | EC               | CORP              | CH        |      5590 | NS      | $16378.70     | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| CRISPR Therapeutics AG                     | CRISPR Therapeutics AG                                     | CUSIP: H17182108<br>LEI: 506700O6IRRIQLT3W370 | Long             | EC               | CORP              | CH        |      5417 | NS      | $325778.38    | 0.43%             |  |  |  | No            |                  1 | On Loan: —       |
| KalVista Pharmaceuticals, Inc.             | KalVista Pharmaceuticals, Inc.                             | CUSIP: 483497103<br>LEI: 529900Q7IDA3WUGRZA51 | Long             | EC               | CORP              | US        |      2831 | NS      | $46088.68     | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| AnaptysBio, Inc.                           | AnaptysBio, Inc.                                           | CUSIP: 032724106<br>LEI: 529900HH4WQT03IG1A12 | Long             | EC               | CORP              | US        |      1550 | NS      | $85327.50     | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| MannKind Corp.                             | MannKind Corp.                                             | CUSIP: 56400P706<br>LEI: 213800GFBCNY1ZFST722 | Long             | EC               | CORP              | US        |     17136 | NS      | $56206.08     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| UroGen Pharma Ltd.                         | UroGen Pharma Ltd.                                         | CUSIP: M96088105<br>LEI: 549300C0YCX7CG2G5D50 | Long             | EC               | CORP              | IL        |      2613 | NS      | $56702.10     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| argenx SE                                  | argenx SE, ADR                                             | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |      1648 | NS      | $1263884.16   | 1.67%             |  |  |  | No            |                  1 | On Loan: No      |
| Iovance Biotherapeutics, Inc.              | Iovance Biotherapeutics, Inc.                              | CUSIP: 462260100<br>LEI: 2549002L8WT2ACU5Q878 | Long             | EC               | CORP              | US        |     22091 | NS      | $85271.26     | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| Krystal Biotech, Inc.                      | Krystal Biotech, Inc.                                      | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |      1646 | NS      | $453703.44    | 0.60%             |  |  |  | No            |                  1 | On Loan: —       |
| Zai Lab Ltd.                               | Zai Lab Ltd., ADR                                          | CUSIP: 98887Q104<br>LEI: 549300P2UYQ9U5LY1T58 | Long             | EC               | CORP              | KY        |      2174 | NS      | $41784.28     | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Rhythm Pharmaceuticals, Inc.               | Rhythm Pharmaceuticals, Inc.                               | CUSIP: 76243J105<br>LEI: 529900JPNWXQ8DPLA551 | Long             | EC               | CORP              | US        |      3774 | NS      | $349963.02    | 0.46%             |  |  |  | No            |                  1 | On Loan: No      |
| Apellis Pharmaceuticals, Inc.              | Apellis Pharmaceuticals, Inc.                              | CUSIP: 03753U106<br>LEI: 254900HS0ZFRXXSB9D42 | Long             | EC               | CORP              | US        |      7068 | NS      | $148145.28    | 0.20%             |  |  |  | No            |                  1 | On Loan: —       |
| Denali Therapeutics Inc.                   | Denali Therapeutics Inc.                                   | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |      8178 | NS      | $173210.04    | 0.23%             |  |  |  | No            |                  1 | On Loan: —       |
| Rocket Pharmaceuticals, Inc.               | Rocket Pharmaceuticals, Inc.                               | CUSIP: 77313F106<br>LEI: 549300R7VV82YUIN4Y93 | Long             | EC               | CORP              | US        |      6041 | NS      | $30265.41     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Evolus, Inc.                               | Evolus, Inc.                                               | CUSIP: 30052C107<br>LEI: 549300VYQRYBQOT8V419 | Long             | EC               | CORP              | US        |      3626 | NS      | $15591.80     | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Amneal Pharmaceuticals, Inc.               | Amneal Pharmaceuticals, Inc.                               | CUSIP: 03168L105<br>LEI: 549300VV176ZO5WQHZ61 | Long             | EC               | CORP              | US        |     17835 | NS      | $246301.35    | 0.33%             |  |  |  | No            |                  1 | On Loan: No      |
| Scholar Rock Holding Corp.                 | Scholar Rock Holding Corp.                                 | CUSIP: 80706P103<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |      5710 | NS      | $252781.70    | 0.33%             |  |  |  | No            |                  1 | On Loan: —       |
| MeiraGTx Holdings PLC                      | MeiraGTx Holdings PLC                                      | CUSIP: G59665102<br>LEI: 54930007YV6NYIOGFZ57 | Long             | EC               | CORP              | KY        |      4490 | NS      | $33944.40     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Autolus Therapeutics PLC                   | Autolus Therapeutics PLC, ADR                              | CUSIP: 05280R100<br>LEI: 549300C0KZP8EYROLL02 | Long             | EC               | CORP              | GB        |     11218 | NS      | $19182.78     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Crinetics Pharmaceuticals, Inc.            | Crinetics Pharmaceuticals, Inc.                            | CUSIP: 22663K107<br>LEI: 549300Q1CNFXK5P31D28 | Long             | EC               | CORP              | US        |      5407 | NS      | $222227.70    | 0.29%             |  |  |  | No            |                  1 | On Loan: —       |
| Replimune Group, Inc.                      | Replimune Group, Inc.                                      | CUSIP: 76029N106<br>LEI: 549300AY704NEIRC4K64 | Long             | EC               | CORP              | US        |      4391 | NS      | $33591.15     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Aquestive Therapeutics, Inc.               | Aquestive Therapeutics, Inc.                               | CUSIP: 03843E104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6813 | NS      | $27252.00     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Altimmune, Inc.                            | Altimmune, Inc.                                            | CUSIP: 02155H200<br>LEI: 549300EOYCQ8SW3NVE64 | Long             | EC               | CORP              | US        |      5817 | NS      | $25071.27     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Arvinas, Inc.                              | Arvinas, Inc.                                              | CUSIP: 04335A105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3599 | NS      | $47758.73     | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Allogene Therapeutics, Inc.                | Allogene Therapeutics, Inc.                                | CUSIP: 019770106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     12556 | NS      | $34905.68     | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Guardant Health, Inc.                      | Guardant Health, Inc.                                      | CUSIP: 40131M109<br>LEI: 254900M8C3E5VC8BR186 | Long             | EC               | CORP              | US        |      7319 | NS      | $687254.10    | 0.91%             |  |  |  | No            |                  1 | On Loan: No      |
| Kodiak Sciences Inc.                       | Kodiak Sciences Inc.                                       | CUSIP: 50015M109<br>LEI: 254900IXI5NI8C9OQE24 | Long             | EC               | CORP              | US        |      2951 | NS      | $79086.80     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Twist Bioscience Corp.                     | Twist Bioscience Corp.                                     | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |      3416 | NS      | $160278.72    | 0.21%             |  |  |  | No            |                  1 | On Loan: —       |
| Eton Pharmaceuticals, Inc.                 | Eton Pharmaceuticals, Inc.                                 | CUSIP: 29772L108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1510 | NS      | $25654.90     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Moderna, Inc.                              | Moderna, Inc.                                              | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |     22109 | NS      | $1184379.13   | 1.56%             |  |  |  | No            |                  1 | On Loan: —       |
| Harrow, Inc.                               | Harrow, Inc.                                               | CUSIP: 415858109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2072 | NS      | $112260.96    | 0.15%             |  |  |  | No            |                  1 | On Loan: —       |
| Gossamer Bio, Inc.                         | Gossamer Bio, Inc.                                         | CUSIP: 38341P102<br>LEI: 549300ZOC0N2W6PSFR58 | Long             | EC               | CORP              | US        |     12911 | NS      | $5485.88      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| CorMedix Inc.                              | CorMedix Inc.                                              | CUSIP: 21900C308<br>LEI: 5299006YIA3L0MBW8358 | Long             | EC               | CORP              | US        |      4414 | NS      | $31471.82     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| BioCryst Pharmaceuticals, Inc.             | BioCryst Pharmaceuticals, Inc.                             | CUSIP: 09058V103<br>LEI: 549300Z0INP1Z5NP6J59 | Long             | EC               | CORP              | US        |     11766 | NS      | $102952.50    | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| Geron Corp.                                | Geron Corp.                                                | CUSIP: 374163103<br>LEI: 549300T282D7Z2YESL90 | Long             | EC               | CORP              | US        |     35647 | NS      | $59886.96     | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Trevi Therapeutics, Inc.                   | Trevi Therapeutics, Inc.                                   | CUSIP: 89532M101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7146 | NS      | $85180.32     | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| Novavax, Inc.                              | Novavax, Inc.                                              | CUSIP: 670002401<br>LEI: 529900J4GJHPEPQ23205 | Long             | EC               | CORP              | US        |      9091 | NS      | $92182.74     | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Genmab A/S                                 | Genmab A/S, ADR                                            | CUSIP: 372303206<br>LEI: 529900MTJPDPE4MHJ122 | Long             | EC               | CORP              | DK        |      3245 | NS      | $95532.80     | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Illumina, Inc.                             | Illumina, Inc.                                             | CUSIP: 452327109<br>LEI: SQ95QG8SR5Q56LSNF682 | Long             | EC               | CORP              | US        |      8646 | NS      | $1162541.16   | 1.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals, Inc.              | Alnylam Pharmaceuticals, Inc.                              | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |      7470 | NS      | $2486912.40   | 3.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Halozyme Therapeutics, Inc.                | Halozyme Therapeutics, Inc.                                | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |      6671 | NS      | $463834.63    | 0.61%             |  |  |  | No            |                  1 | On Loan: No      |
| IDEAYA Biosciences, Inc.                   | IDEAYA Biosciences, Inc.                                   | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |      4907 | NS      | $158005.40    | 0.21%             |  |  |  | No            |                  1 | On Loan: —       |
| Bicycle Therapeutics PLC                   | Bicycle Therapeutics PLC, ADR                              | CUSIP: 088786108<br>LEI: 213800XKUI6R7GKC3E43 | Long             | EC               | CORP              | GB        |      2589 | NS      | $14834.97     | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Stoke Therapeutics, Inc.                   | Stoke Therapeutics, Inc.                                   | CUSIP: 86150R107<br>LEI: 549300RD25SS2DIJHJ67 | Long             | EC               | CORP              | US        |      3184 | NS      | $115929.44    | 0.15%             |  |  |  | No            |                  1 | On Loan: —       |
| Personalis, Inc.                           | Personalis, Inc.                                           | CUSIP: 71535D106<br>LEI: 549300EZ2NYFK7H0US48 | Long             | EC               | CORP              | US        |      4964 | NS      | $44973.84     | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Adaptive Biotechnologies Corp.             | Adaptive Biotechnologies Corp.                             | CUSIP: 00650F109<br>LEI: 549300ZTF7OT1FW66Q96 | Long             | EC               | CORP              | US        |      8546 | NS      | $136906.92    | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| BridgeBio Pharma, Inc.                     | BridgeBio Pharma, Inc.                                     | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |     10918 | NS      | $725828.64    | 0.96%             |  |  |  | No            |                  1 | On Loan: No      |
| Mirum Pharmaceuticals, Inc.                | Mirum Pharmaceuticals, Inc.                                | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |      2923 | NS      | $269763.67    | 0.36%             |  |  |  | No            |                  1 | On Loan: —       |
| Fulcrum Therapeutics, Inc.                 | Fulcrum Therapeutics, Inc.                                 | CUSIP: 359616109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3042 | NS      | $25491.96     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Castle Biosciences, Inc.                   | Castle Biosciences, Inc.                                   | CUSIP: 14843C105<br>LEI: 2549007M2Q4HLR1XD252 | Long             | EC               | CORP              | US        |      1619 | NS      | $47873.83     | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| 10x Genomics, Inc.                         | 10x Genomics, Inc., Class A                                | CUSIP: 88025U109<br>LEI: 5493003Z6741WNLG7H43 | Long             | EC               | CORP              | US        |      6513 | NS      | $150124.65    | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcturus Therapeutics Holdings Inc.        | Arcturus Therapeutics Holdings Inc.                        | CUSIP: 03969T109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1610 | NS      | $13250.30     | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| BioNTech SE                                | BioNTech SE, ADR                                           | CUSIP: 09075V102<br>LEI: 894500UZJ5LG1F8J1U58 | Long             | EC               | CORP              | DE        |      5726 | NS      | $631176.98    | 0.83%             |  |  |  | No            |                  1 | On Loan: No      |
| Vir Biotechnology, Inc.                    | Vir Biotechnology, Inc.                                    | CUSIP: 92764N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7785 | NS      | $70765.65     | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Phathom Pharmaceuticals, Inc.              | Phathom Pharmaceuticals, Inc.                              | CUSIP: 71722W107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3967 | NS      | $49825.52     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Cabaletta Bio, Inc.                        | Cabaletta Bio, Inc.                                        | CUSIP: 12674W109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5395 | NS      | $17911.40     | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Amgen Inc.                                 | Amgen Inc.                                                 | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |     17796 | NS      | $6907695.36   | 9.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Immunovant, Inc.                           | Immunovant, Inc.                                           | CUSIP: 45258J102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      9812 | NS      | $272086.76    | 0.36%             |  |  |  | No            |                  1 | On Loan: —       |
| NovaBridge Biosciences                     | NovaBridge Biosciences, ADR                                | CUSIP: 44975P103<br>LEI: 549300L1A5T19703RR64 | Long             | EC               | CORP              | KY        |      5799 | NS      | $19020.72     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Black Diamond Therapeutics, Inc.           | Black Diamond Therapeutics, Inc.                           | CUSIP: 09203E105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3178 | NS      | $7849.66      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Beam Therapeutics Inc.                     | Beam Therapeutics Inc.                                     | CUSIP: 07373V105<br>LEI: 254900QL5GLNKGR8YH71 | Long             | EC               | CORP              | US        |      5686 | NS      | $161823.56    | 0.21%             |  |  |  | No            |                  1 | On Loan: —       |
| Precigen, Inc.                             | Precigen, Inc.                                             | CUSIP: 74017N105<br>LEI: 549300XCWNQU35K64G19 | Long             | EC               | CORP              | US        |     19747 | NS      | $74841.13     | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| Arcutis Biotherapeutics, Inc.              | Arcutis Biotherapeutics, Inc.                              | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6836 | NS      | $184366.92    | 0.24%             |  |  |  | No            |                  1 | On Loan: —       |
| Revolution Medicines, Inc.                 | Revolution Medicines, Inc.                                 | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |     10938 | NS      | $1115894.76   | 1.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Invesco Government & Agency Portfolio      | Invesco Government & Agency Portfolio, Institutional Class | CUSIP: 825252885<br>LEI: 5493007T1J7WZ5QI1A47 | Long             | STIV             | RF                | US        |     39488 | NS      | $39488.05     | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Keros Therapeutics, Inc.                   | Keros Therapeutics, Inc.                                   | CUSIP: 492327101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1724 | NS      | $24463.56     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| ORIC Pharmaceuticals, Inc.                 | ORIC Pharmaceuticals, Inc.                                 | CUSIP: 68622P109<br>LEI: 54930033FJRNEYBW0L25 | Long             | EC               | CORP              | US        |      5451 | NS      | $73315.95     | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| Invesco Private Government Fund            | Invesco Private Government Fund                            | CUSIP: N/A<br>LEI: N/A                        | Long             | STIV             | PF                | US        |   4201477 | NS      | $4201476.69   | 5.55%             |  |  |  | No            |                  2 | On Loan: No      |
| Larimar Therapeutics, Inc.                 | Larimar Therapeutics, Inc.                                 | CUSIP: 517125100<br>LEI: 529900NCBZHTTJV6HX73 | Long             | EC               | CORP              | US        |      4770 | NS      | $25328.70     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Legend Biotech Corp.                       | Legend Biotech Corp., ADR                                  | CUSIP: 52490G102<br>LEI: 254900EIUFZTW136H859 | Long             | EC               | CORP              | KY        |      4707 | NS      | $89433.00     | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Royalty Pharma PLC                         | Royalty Pharma PLC, Class A                                | CUSIP: G7709Q104<br>LEI: 549300FGFN7VOK8BZR03 | Long             | EC               | CORP              | GB        |     24171 | NS      | $1116941.91   | 1.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Vaxcyte, Inc.                              | Vaxcyte, Inc.                                              | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |      7425 | NS      | $458419.50    | 0.61%             |  |  |  | No            |                  1 | On Loan: —       |
| Relay Therapeutics, Inc.                   | Relay Therapeutics, Inc.                                   | CUSIP: 75943R102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      9680 | NS      | $99316.80     | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Invesco Private Prime Fund                 | Invesco Private Prime Fund                                 | CUSIP: N/A<br>LEI: N/A                        | Long             | STIV             | PF                | US        |  10825717 | NS      | $10825716.74  | 14.29%            |  |  |  | No            |                  2 | On Loan: No      |
| Gilead Sciences, Inc.                      | Gilead Sciences, Inc.                                      | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |     48865 | NS      | $7278441.75   | 9.61%             |  |  |  | No            |                  1 | On Loan: No      |
| Annexon, Inc.                              | Annexon, Inc.                                              | CUSIP: 03589W102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8089 | NS      | $45298.40     | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Nurix Therapeutics, Inc.                   | Nurix Therapeutics, Inc.                                   | CUSIP: 67080M103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5681 | NS      | $90725.57     | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Sanofi                                     | Sanofi, ADR                                                | CUSIP: 80105N105<br>LEI: 549300E9PC51EN656011 | Long             | EC               | CORP              | FR        |     14988 | NS      | $729316.08    | 0.96%             |  |  |  | No            |                  1 | On Loan: No      |
| Harmony Biosciences Holdings, Inc.         | Harmony Biosciences Holdings, Inc.                         | CUSIP: 413197104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3206 | NS      | $91499.24     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Kymera Therapeutics, Inc.                  | Kymera Therapeutics, Inc.                                  | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4067 | NS      | $371520.45    | 0.49%             |  |  |  | No            |                  1 | On Loan: —       |
| Silence Therapeutics PLC                   | Silence Therapeutics PLC, ADR                              | CUSIP: 82686Q101<br>LEI: 213800SSURRJBX85SQ91 | Long             | EC               | CORP              | GB        |      2621 | NS      | $14258.24     | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Dyne Therapeutics, Inc.                    | Dyne Therapeutics, Inc.                                    | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7965 | NS      | $124413.30    | 0.16%             |  |  |  | No            |                  1 | On Loan: —       |
| COMPASS Pathways PLC                       | COMPASS Pathways PLC, ADR                                  | CUSIP: 20451W101<br>LEI: 213800N7CUZIC6QSTZ31 | Long             | EC               | CORP              | GB        |      5259 | NS      | $36287.10     | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Taysha Gene Therapies Inc.                 | Taysha Gene Therapies Inc.                                 | CUSIP: 877619106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     15289 | NS      | $69259.17     | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| C4 Therapeutics, Inc.                      | C4 Therapeutics, Inc.                                      | CUSIP: 12529R107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5430 | NS      | $14661.00     | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Cogent Biosciences, Inc.                   | Cogent Biosciences, Inc.                                   | CUSIP: 19240Q201<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8738 | NS      | $339471.30    | 0.45%             |  |  |  | No            |                  1 | On Loan: —       |
| Tarsus Pharmaceuticals, Inc.               | Tarsus Pharmaceuticals, Inc.                               | CUSIP: 87650L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2367 | NS      | $178755.84    | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Foghorn Therapeutics Inc.                  | Foghorn Therapeutics Inc.                                  | CUSIP: 344174107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3158 | NS      | $17937.44     | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Viatris Inc.                               | Viatris Inc.                                               | CUSIP: 92556V106<br>LEI: 254900ZZTSW7NL773X71 | Long             | EC               | CORP              | US        |     65178 | NS      | $973107.54    | 1.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Maravai LifeSciences Holdings, Inc.        | Maravai LifeSciences Holdings, Inc., Class A               | CUSIP: 56600D107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8103 | NS      | $28846.68     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Olema Pharmaceuticals, Inc.                | Olema Pharmaceuticals, Inc.                                | CUSIP: 68062P106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4401 | NS      | $106504.20    | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| Travere Therapeutics, Inc.                 | Travere Therapeutics, Inc.                                 | CUSIP: 89422G107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4995 | NS      | $148801.05    | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Atea Pharmaceuticals, Inc.                 | Atea Pharmaceuticals, Inc.                                 | CUSIP: 04683R106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4376 | NS      | $20479.68     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Vertex Pharmaceuticals Inc.                | Vertex Pharmaceuticals Inc.                                | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |     14178 | NS      | $7044055.74   | 9.30%             |  |  |  | No            |                  1 | On Loan: No      |
| ARS Pharmaceuticals, Inc.                  | ARS Pharmaceuticals, Inc.                                  | CUSIP: 82835W108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5518 | NS      | $51207.04     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| EyePoint, Inc.                             | EyePoint, Inc.                                             | CUSIP: 30233G209<br>LEI: 549300QE1RU34T50MR69 | Long             | EC               | CORP              | US        |      4637 | NS      | $81425.72     | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| 4D Molecular Therapeutics, Inc.            | 4D Molecular Therapeutics, Inc.                            | CUSIP: 35104E100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3185 | NS      | $30767.10     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| AbCellera Biologics Inc.                   | AbCellera Biologics Inc.                                   | CUSIP: 00288U106<br>LEI: 9845000861BC95FF9F73 | Long             | EC               | CORP              | CA        |     16724 | NS      | $60373.64     | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Cullinan Therapeutics, Inc.                | Cullinan Therapeutics, Inc.                                | CUSIP: 230031106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3316 | NS      | $51398.00     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Zevra Therapeutics, Inc.                   | Zevra Therapeutics, Inc.                                   | CUSIP: 488445206<br>LEI: 254900CU6T74V18Y1W18 | Long             | EC               | CORP              | US        |      3142 | NS      | $28058.06     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Immunocore Holdings PLC                    | Immunocore Holdings PLC, ADR                               | CUSIP: 45258D105<br>LEI: 213800IUE3DFS84BVN18 | Long             | EC               | CORP              | GB        |      2432 | NS      | $78553.60     | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| Pharvaris N.V.                             | Pharvaris N.V.                                             | CUSIP: N69605108<br>LEI: 9845003BE146D3B75D32 | Long             | EC               | CORP              | NL        |      3591 | NS      | $101948.49    | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Sana Biotechnology, Inc.                   | Sana Biotechnology, Inc.                                   | CUSIP: 799566104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     14886 | NS      | $62670.06     | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Terns Pharmaceuticals, Inc.                | Terns Pharmaceuticals, Inc.                                | CUSIP: 880881107<br>LEI: 254900S1ZDQMF4MYP709 | Long             | EC               | CORP              | US        |      5023 | NS      | $211568.76    | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| ImmunityBio, Inc.                          | ImmunityBio, Inc.                                          | CUSIP: 45256X103<br>LEI: 529900J9XLBR4HFL4B83 | Long             | EC               | CORP              | US        |     55881 | NS      | $546516.18    | 0.72%             |  |  |  | No            |                  1 | On Loan: —       |
| Design Therapeutics, Inc.                  | Design Therapeutics, Inc.                                  | CUSIP: 25056L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3177 | NS      | $33167.88     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Edgewise Therapeutics, Inc.                | Edgewise Therapeutics, Inc.                                | CUSIP: 28036F105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5934 | NS      | $180630.96    | 0.24%             |  |  |  | No            |                  1 | On Loan: —       |
| Recursion Pharmaceuticals, Inc.            | Recursion Pharmaceuticals, Inc., Class A                   | CUSIP: 75629V104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     28735 | NS      | $105457.45    | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| Omeros Corp.                               | Omeros Corp.                                               | CUSIP: 682143102<br>LEI: 549300CJWLXX2MXVVV71 | Long             | EC               | CORP              | US        |      3957 | NS      | $47681.85     | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| United Therapeutics Corp.                  | United Therapeutics Corp.                                  | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |      2437 | NS      | $1228004.30   | 1.62%             |  |  |  | No            |                  1 | On Loan: No      |
| Vera Therapeutics, Inc.                    | Vera Therapeutics, Inc.                                    | CUSIP: 92337R101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3585 | NS      | $146232.15    | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Day One Biopharmaceuticals, Inc.           | Day One Biopharmaceuticals, Inc.                           | CUSIP: 23954D109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5740 | NS      | $60844.00     | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Summit Therapeutics Inc.                   | Summit Therapeutics Inc.                                   | CUSIP: 86627T108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     42174 | NS      | $699666.66    | 0.92%             |  |  |  | No            |                  1 | On Loan: —       |
| Centessa Pharmaceuticals PLC               | Centessa Pharmaceuticals PLC, ADR                          | CUSIP: 152309100<br>LEI: 213800GIDAARDSKOI827 | Long             | EC               | CORP              | GB        |      5405 | NS      | $145178.30    | 0.19%             |  |  |  | No            |                  1 | On Loan: —       |
| Janux Therapeutics, Inc.                   | Janux Therapeutics, Inc.                                   | CUSIP: 47103J105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3365 | NS      | $45797.65     | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Quantum-Si Inc.                            | Quantum-Si Inc.                                            | CUSIP: 74765K105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     10933 | NS      | $10456.32     | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Monte Rosa Therapeutics, Inc.              | Monte Rosa Therapeutics, Inc.                              | CUSIP: 61225M102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3640 | NS      | $64610.00     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| GH Research PLC                            | GH Research PLC                                            | CUSIP: G3855L106<br>LEI: 875500HKJS7QQG6EWH62 | Long             | EC               | CORP              | IE        |      3456 | NS      | $51321.60     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Alpha Teknova, Inc.                        | Alpha Teknova, Inc.                                        | CUSIP: 02080L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2973 | NS      | $7670.34      | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Erasca, Inc.                               | Erasca, Inc.                                               | CUSIP: 29479A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     15831 | NS      | $216251.46    | 0.29%             |  |  |  | No            |                  1 | On Loan: —       |
| AbSci Corp.                                | AbSci Corp.                                                | CUSIP: 00091E109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8394 | NS      | $22999.56     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Caribou Biosciences, Inc.                  | Caribou Biosciences, Inc.                                  | CUSIP: 142038108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5225 | NS      | $9927.50      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Candel Therapeutics, Inc.                  | Candel Therapeutics, Inc.                                  | CUSIP: 137404109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3078 | NS      | $16159.50     | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Nuvalent, Inc.                             | Nuvalent, Inc., Class A                                    | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4101 | NS      | $418096.95    | 0.55%             |  |  |  | No            |                  1 | On Loan: No      |
| Immuneering Corp.                          | Immuneering Corp., Class A                                 | CUSIP: 45254E107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3615 | NS      | $18038.85     | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Rani Therapeutics Holdings, Inc.           | Rani Therapeutics Holdings, Inc.                           | CUSIP: 753018100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5458 | NS      | $7477.46      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Tenaya Therapeutics, Inc.                  | Tenaya Therapeutics, Inc.                                  | CUSIP: 87990A106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      9284 | NS      | $5215.75      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Invivyd, Inc.                              | Invivyd, Inc.                                              | CUSIP: 00534A102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     15472 | NS      | $26147.68     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Tango Therapeutics Inc.                    | Tango Therapeutics Inc.                                    | CUSIP: 87583X109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7535 | NS      | $83939.90     | 0.11%             |  |  |  | No            |                  1 | On Loan: —       |
| Humacyte, Inc.                             | Humacyte, Inc.                                             | CUSIP: 44486Q103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     10465 | NS      | $11668.48     | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Tyra Biosciences, Inc.                     | Tyra Biosciences, Inc.                                     | CUSIP: 90240B106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2966 | NS      | $98797.46     | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Roivant Sciences Ltd.                      | Roivant Sciences Ltd.                                      | CUSIP: G76279101<br>LEI: 549300DL466NY5J6U724 | Long             | EC               | CORP              | BM        |     39369 | NS      | $1139338.86   | 1.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Xeris Biopharma Holdings, Inc.             | Xeris Biopharma Holdings, Inc.                             | CUSIP: 98422E103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      9253 | NS      | $56628.36     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Pyxis Oncology, Inc.                       | Pyxis Oncology, Inc.                                       | CUSIP: 747324101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3526 | NS      | $5183.22      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Ventyx Biosciences, Inc.                   | Ventyx Biosciences, Inc.                                   | CUSIP: 92332V107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3977 | NS      | $55558.69     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Ironwood Pharmaceuticals, Inc.             | Ironwood Pharmaceuticals, Inc.                             | CUSIP: 46333X108<br>LEI: 549300PC8MR6QHH6P296 | Long             | EC               | CORP              | US        |      9099 | NS      | $31118.58     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Aura Biosciences, Inc.                     | Aura Biosciences, Inc.                                     | CUSIP: 05153U107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3566 | NS      | $21003.74     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Entrada Therapeutics, Inc.                 | Entrada Therapeutics, Inc.                                 | CUSIP: 29384C108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2126 | NS      | $25363.18     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Amylyx Pharmaceuticals, Inc.               | Amylyx Pharmaceuticals, Inc.                               | CUSIP: 03237H101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6115 | NS      | $92764.55     | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Arcellx, Inc.                              | Arcellx, Inc.                                              | CUSIP: 03940C100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3276 | NS      | $372776.04    | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Codexis, Inc.                              | Codexis, Inc.                                              | CUSIP: 192005106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5176 | NS      | $5227.76      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Amicus Therapeutics, Inc.                  | Amicus Therapeutics, Inc.                                  | CUSIP: 03152W109<br>LEI: 549300MRD1SMUTNBPQ53 | Long             | EC               | CORP              | US        |     17240 | NS      | $247738.80    | 0.33%             |  |  |  | No            |                  1 | On Loan: No      |
| Exelixis, Inc.                             | Exelixis, Inc.                                             | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |     15175 | NS      | $668610.50    | 0.88%             |  |  |  | No            |                  1 | On Loan: No      |
| PepGen Inc.                                | PepGen Inc.                                                | CUSIP: 713317105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3853 | NS      | $23965.66     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Alvotech                                   | Alvotech                                                   | CUSIP: L01800108<br>LEI: 222100DCZBOWV5DZ8372 | Long             | EC               | CORP              | LU        |     17492 | NS      | $69793.08     | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Third Harmonic Bio, Inc.                   | Third Harmonic Bio, Inc., Class B                          | CUSIP: 88427A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1661 | NS      | $49.83        | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Pacific Biosciences of California, Inc.    | Pacific Biosciences of California, Inc.                    | CUSIP: 69404D108<br>LEI: 529900F1BWRE1M0KZN89 | Long             | EC               | CORP              | US        |     16852 | NS      | $28311.36     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Zymeworks Inc.                             | Zymeworks Inc.                                             | CUSIP: 98985Y108<br>LEI: 894500AHOYAGYLYZJL67 | Long             | EC               | CORP              | US        |      4184 | NS      | $97445.36     | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Prime Medicine, Inc.                       | Prime Medicine, Inc.                                       | CUSIP: 74168J101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     10067 | NS      | $46509.54     | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Solid Biosciences Inc.                     | Solid Biosciences Inc.                                     | CUSIP: 83422E204<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4366 | NS      | $27112.86     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| OmniAb, Inc.                               | OmniAb, Inc.                                               | CUSIP: 68218J103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8054 | NS      | $13852.88     | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| OmniAb, Inc.                               | OmniAb, Inc., Rts., 2027-11-02                             | CUSIP: 68218J202<br>LEI: 5493008K7TB0IKP37H79 | Long             | EC               | CORP              | US        |       125 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  3 | On Loan: —       |
| OmniAb, Inc.                               | OmniAb, Inc., Rts., expiring 2027-11-02                    | CUSIP: 68218J301<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       125 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| NewAmsterdam Pharma Co. N.V.               | NewAmsterdam Pharma Co. N.V.                               | CUSIP: N62509109<br>LEI: 984500B6549TF6E14D36 | Long             | EC               | CORP              | NL        |      6442 | NS      | $228433.32    | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Disc Medicine, Inc.                        | Disc Medicine, Inc.                                        | CUSIP: 254604101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2105 | NS      | $140235.10    | 0.19%             |  |  |  | No            |                  1 | On Loan: —       |
| Orchestra Biomed Holdings, Inc.            | Orchestra Biomed Holdings, Inc.                            | CUSIP: 68572M106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3155 | NS      | $13818.90     | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Structure Therapeutics Inc.                | Structure Therapeutics Inc., ADR                           | CUSIP: 86366E106<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |      3736 | NS      | $235293.28    | 0.31%             |  |  |  | No            |                  1 | On Loan: —       |
| Mineralys Therapeutics, Inc.               | Mineralys Therapeutics, Inc.                               | CUSIP: 603170101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4428 | NS      | $129563.28    | 0.17%             |  |  |  | No            |                  1 | On Loan: —       |
| Enliven Therapeutics, Inc.                 | Enliven Therapeutics, Inc.                                 | CUSIP: 29337E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3328 | NS      | $98808.32     | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Fortrea Holdings Inc.                      | Fortrea Holdings Inc.                                      | CUSIP: 34965K107<br>LEI: 5493000FIVFABOVCDU97 | Long             | EC               | CORP              | US        |      5176 | NS      | $55486.72     | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Pacira Biosciences, Inc.                   | Pacira Biosciences, Inc.                                   | CUSIP: 695127100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2398 | NS      | $52540.18     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Apogee Therapeutics, Inc.                  | Apogee Therapeutics, Inc.                                  | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3075 | NS      | $215250.00    | 0.28%             |  |  |  | No            |                  1 | On Loan: —       |
| Sagimet Biosciences Inc.                   | Sagimet Biosciences Inc., Class A                          | CUSIP: 786700104<br>LEI: 2549002OT2F8BV0VPD02 | Long             | EC               | CORP              | US        |      1749 | NS      | $9986.79      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Spyre Therapeutics, Inc.                   | Spyre Therapeutics, Inc.                                   | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |      4352 | NS      | $187179.52    | 0.25%             |  |  |  | No            |                  1 | On Loan: —       |
| Neumora Therapeutics, Inc.                 | Neumora Therapeutics, Inc.                                 | CUSIP: 640979100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      9348 | NS      | $32624.52     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Abivax S.A.                                | Abivax S.A., ADR                                           | CUSIP: 00370M103<br>LEI: 969500D8TMNB184OJU95 | Long             | EC               | CORP              | FR        |      3337 | NS      | $404711.36    | 0.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Lexeo Therapeutics, Inc.                   | Lexeo Therapeutics, Inc.                                   | CUSIP: 52886X107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4094 | NS      | $29394.92     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Praxis Precision Medicines, Inc.           | Praxis Precision Medicines, Inc.                           | CUSIP: 74006W207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1420 | NS      | $478185.00    | 0.63%             |  |  |  | No            |                  1 | On Loan: —       |
| Cartesian Therapeutics, Inc.               | Cartesian Therapeutics, Inc., Rts., 2050-12-31             | CUSIP: 816212112<br>LEI: 529900NMN0LACZOL7C43 | Long             | EC               | CORP              | US        |      2633 | NS      | $359.22       | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Neurogene Inc.                             | Neurogene Inc.                                             | CUSIP: 64135M105<br>LEI: 529900A7VIY892SZVW73 | Long             | EC               | CORP              | US        |       848 | NS      | $19919.52     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Mesoblast Ltd.                             | Mesoblast Ltd., ADR                                        | CUSIP: 590717401<br>LEI: 529900J5ALF3JG921927 | Long             | EC               | CORP              | AU        |      2721 | NS      | $43127.85     | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| CG Oncology, Inc.                          | CG Oncology, Inc.                                          | CUSIP: 156944100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4605 | NS      | $270774.00    | 0.36%             |  |  |  | No            |                  1 | On Loan: —       |
| ArriVent Biopharma, Inc.                   | ArriVent Biopharma, Inc.                                   | CUSIP: 04272N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2313 | NS      | $53129.61     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Kyverna Therapeutics, Inc.                 | Kyverna Therapeutics, Inc.                                 | CUSIP: 501976104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2433 | NS      | $19974.93     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Alkermes PLC                               | Alkermes PLC                                               | CUSIP: G01767105<br>LEI: 549300YHRMYLL071E243 | Long             | EC               | CORP              | IE        |      9274 | NS      | $279147.40    | 0.37%             |  |  |  | No            |                  1 | On Loan: —       |
| LENZ Therapeutics, Inc.                    | LENZ Therapeutics, Inc.                                    | CUSIP: 52635N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1768 | NS      | $23850.32     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Contineum Therapeutics, Inc.               | Contineum Therapeutics, Inc., Class A                      | CUSIP: 21217B100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1293 | NS      | $19834.62     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Inhibrx Biosciences, Inc.                  | Inhibrx Biosciences, Inc.                                  | CUSIP: 45720N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       807 | NS      | $59822.91     | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Rapport Therapeutics, Inc.                 | Rapport Therapeutics, Inc.                                 | CUSIP: 75383L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2657 | NS      | $77132.71     | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| Tempus AI, Inc.                            | Tempus AI, Inc., Class A                                   | CUSIP: 88023B103<br>LEI: 2549009LA0KWRAGQBX50 | Long             | EC               | CORP              | US        |      9809 | NS      | $522329.25    | 0.69%             |  |  |  | No            |                  1 | On Loan: —       |
| GRAIL, Inc.                                | GRAIL, Inc.                                                | CUSIP: 384747101<br>LEI: 2549009XSNESW3VE8024 | Long             | EC               | CORP              | US        |      2176 | NS      | $115828.48    | 0.15%             |  |  |  | No            |                  1 | On Loan: —       |
| Tectonic Therapeutic, Inc.                 | Tectonic Therapeutic, Inc.                                 | CUSIP: 878972108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1045 | NS      | $24505.25     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Rigel Pharmaceuticals, Inc.                | Rigel Pharmaceuticals, Inc.                                | CUSIP: 766559702<br>LEI: 529900KPTNUS5J8K9K66 | Long             | EC               | CORP              | US        |      1019 | NS      | $35400.06     | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Kiniksa Pharmaceuticals International, PLC | Kiniksa Pharmaceuticals International, PLC                 | CUSIP: G52694109<br>LEI: N/A                  | Long             | EC               | CORP              | GB        |      2538 | NS      | $112915.62    | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Alumis Inc.                                | Alumis Inc.                                                | CUSIP: 022307102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5443 | NS      | $161602.67    | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Oruka Therapeutics, Inc.                   | Oruka Therapeutics, Inc.                                   | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |      2692 | NS      | $92631.72     | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Bicara Therapeutics Inc.                   | Bicara Therapeutics Inc.                                   | CUSIP: 055477103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3072 | NS      | $51548.16     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Zenas Biopharma, Inc.                      | Zenas Biopharma, Inc.                                      | CUSIP: 98937L105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2980 | NS      | $78523.00     | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| MBX Biosciences, Inc.                      | MBX Biosciences, Inc.                                      | CUSIP: 55287L101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2526 | NS      | $82221.30     | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Jazz Pharmaceuticals PLC                   | Jazz Pharmaceuticals PLC                                   | CUSIP: G50871105<br>LEI: 635400GAUMJCLEZRRV50 | Long             | EC               | CORP              | IE        |      3442 | NS      | $654048.84    | 0.86%             |  |  |  | No            |                  1 | On Loan: No      |
| BioAge Labs, Inc.                          | BioAge Labs, Inc.                                          | CUSIP: 09077V100<br>LEI: 529900NG0C40250Z7875 | Long             | EC               | CORP              | US        |      2018 | NS      | $44940.86     | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Upstream Bio, Inc.                         | Upstream Bio, Inc.                                         | CUSIP: 91678A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3038 | NS      | $23331.84     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Septerna, Inc.                             | Septerna, Inc.                                             | CUSIP: 81734D104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2520 | NS      | $73130.40     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Maze Therapeutics, Inc.                    | Maze Therapeutics, Inc.                                    | CUSIP: 578784100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2678 | NS      | $122090.02    | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Sionna Therapeutics, Inc.                  | Sionna Therapeutics, Inc.                                  | CUSIP: 829401108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2514 | NS      | $91861.56     | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Aardvark Therapeutics, Inc.                | Aardvark Therapeutics, Inc.                                | CUSIP: 002942100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1232 | NS      | $15387.68     | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Supernus Pharmaceuticals, Inc.             | Supernus Pharmaceuticals, Inc.                             | CUSIP: 868459108<br>LEI: 549300GRM36VBKISYJ58 | Long             | EC               | CORP              | US        |      3195 | NS      | $174862.35    | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen Inc.                                | Biogen Inc.                                                | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |      8295 | NS      | $1591146.90   | 2.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Sarepta Therapeutics, Inc.                 | Sarepta Therapeutics, Inc.                                 | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |      5837 | NS      | $97828.12     | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Grifols, S.A.                              | Grifols, S.A., ADR                                         | CUSIP: 398438408<br>LEI: 959800HSSNXWRKBK4N60 | Long             | EC               | CORP              | ES        |      6813 | NS      | $61998.30     | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| BioMarin Pharmaceutical Inc.               | BioMarin Pharmaceutical Inc.                               | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |     10885 | NS      | $671931.05    | 0.89%             |  |  |  | No            |                  1 | On Loan: No      |
| Lyell Immunopharma, Inc.                   | Lyell Immunopharma, Inc.                                   | CUSIP: 55083R203<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1207 | NS      | $28968.00     | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| Caris Life Sciences, Inc.                  | Caris Life Sciences, Inc.                                  | CUSIP: 142152107<br>LEI: 549300LX5LO78M5VPY43 | Long             | EC               | CORP              | US        |     15855 | NS      | $319319.70    | 0.42%             |  |  |  | No            |                  1 | On Loan: —       |
| RAPT Therapeutics, Inc.                    | RAPT Therapeutics, Inc.                                    | CUSIP: 75382E208<br>LEI: 549300MB473BIU78ES48 | Long             | EC               | CORP              | US        |      1551 | NS      | $89926.98     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Jyong Biotech Ltd.                         | Jyong Biotech Ltd.                                         | CUSIP: G83116106<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |      4238 | NS      | $9069.32      | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Puma Biotechnology, Inc.                   | Puma Biotechnology, Inc.                                   | CUSIP: 74587V107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2824 | NS      | $16096.80     | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Vor BioPharma Inc.                         | Vor BioPharma Inc.                                         | CUSIP: 929033207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |       960 | NS      | $14822.40     | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Prothena Corp. PLC                         | Prothena Corp. PLC                                         | CUSIP: G72800108<br>LEI: 5299009ZXQ8NIIJ8OL30 | Long             | EC               | CORP              | IE        |      2992 | NS      | $25940.64     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Insmed Inc.                                | Insmed Inc.                                                | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |     12065 | NS      | $1801666.45   | 2.38%             |  |  |  | No            |                  1 | On Loan: No      |
| Novo Nordisk A/S                           | Novo Nordisk A/S                                           | CUSIP: 009CVR044<br>LEI: 549300DAQ1CVT6CXN342 | Long             | EC               | CORP              | DK        |      3794 | NS      | $0.00         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| AtaiBeckley Inc.                           | AtaiBeckley Inc.                                           | CUSIP: 04650F101<br>LEI: 529900HOVZ0MXOBQ5Y47 | Long             | EC               | CORP              | US        |     20269 | NS      | $73576.47     | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| Definium Therapeutics, Inc.                | Definium Therapeutics, Inc.                                | CUSIP: 24477V105<br>LEI: 549300QY8KN1O6RPFJ13 | Long             | EC               | CORP              | CA        |      5503 | NS      | $96027.35     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Indivior Pharmaceuticals, Inc.             | Indivior Pharmaceuticals, Inc.                             | CUSIP: 45579U109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6991 | NS      | $228745.52    | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Savara Inc.                                | Savara Inc.                                                | CUSIP: 805111101<br>LEI: 5493002JO0WM3YMJXG33 | Long             | EC               | CORP              | US        |     11348 | NS      | $68314.96     | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| Enanta Pharmaceuticals, Inc.               | Enanta Pharmaceuticals, Inc.                               | CUSIP: 29251M106<br>LEI: 529900SSN4DODDQSN594 | Long             | EC               | CORP              | US        |      1604 | NS      | $22937.20     | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Kamada Ltd.                                | Kamada Ltd.                                                | CUSIP: M6240T109<br>LEI: N/A                  | Long             | EC               | CORP              | IL        |      3210 | NS      | $27927.00     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC Therapeutics, Inc.                     | PTC Therapeutics, Inc.                                     | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |      4553 | NS      | $310469.07    | 0.41%             |  |  |  | No            |                  1 | On Loan: —       |
| Cytokinetics, Inc.                         | Cytokinetics, Inc.                                         | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |      6884 | NS      | $428322.48    | 0.57%             |  |  |  | No            |                  1 | On Loan: —       |
| Esperion Therapeutics, Inc.                | Esperion Therapeutics, Inc.                                | CUSIP: 29664W105<br>LEI: 549300OFU56UKEWVUS92 | Long             | EC               | CORP              | US        |     13354 | NS      | $44735.90     | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| ANI Pharmaceuticals, Inc.                  | ANI Pharmaceuticals, Inc.                                  | CUSIP: 00182C103<br>LEI: 5493000T6CXTND40YH31 | Long             | EC               | CORP              | US        |      1263 | NS      | $93335.70     | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Agios Pharmaceuticals, Inc.                | Agios Pharmaceuticals, Inc.                                | CUSIP: 00847X104<br>LEI: 529900ONJHY8EOGYT555 | Long             | EC               | CORP              | US        |      3239 | NS      | $97914.97     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Vanda Pharmaceuticals Inc.                 | Vanda Pharmaceuticals Inc.                                 | CUSIP: 921659108<br>LEI: 529900AY8VOOQBKJ0O70 | Long             | EC               | CORP              | US        |      3317 | NS      | $29554.47     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Incyte Corp.                               | Incyte Corp.                                               | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |     11115 | NS      | $1125616.05   | 1.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Veracyte, Inc.                             | Veracyte, Inc.                                             | CUSIP: 92337F107<br>LEI: 529900ESWZRHXOW27Z37 | Long             | EC               | CORP              | US        |      4424 | NS      | $161874.16    | 0.21%             |  |  |  | No            |                  1 | On Loan: —       |
| Neurocrine Biosciences, Inc.               | Neurocrine Biosciences, Inc.                               | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |      5641 | NS      | $746022.25    | 0.98%             |  |  |  | No            |                  1 | On Loan: No      |
| Xencor, Inc.                               | Xencor, Inc.                                               | CUSIP: 98401F105<br>LEI: 549300V5IF65437JKG30 | Long             | EC               | CORP              | US        |      3980 | NS      | $50824.60     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Ultragenyx Pharmaceutical Inc.             | Ultragenyx Pharmaceutical Inc.                             | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |      5405 | NS      | $126422.95    | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| uniQure N.V.                               | uniQure N.V.                                               | CUSIP: N90064101<br>LEI: 724500RPCTZLFYJZ3S98 | Long             | EC               | CORP              | NL        |      3468 | NS      | $54204.84     | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Phibro Animal Health Corp.                 | Phibro Animal Health Corp., Class A                        | CUSIP: 71742Q106<br>LEI: 549300U24SP4AF2JUX52 | Long             | EC               | CORP              | US        |      1124 | NS      | $61359.16     | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Theravance Biopharma Inc.                  | Theravance Biopharma Inc.                                  | CUSIP: G8807B106<br>LEI: 5493007VTSXP4Z6MIW52 | Long             | EC               | CORP              | KY        |      2837 | NS      | $51775.25     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Regeneron Pharmaceuticals, Inc.            | Regeneron Pharmaceuticals, Inc.                            | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |      5839 | NS      | $4564171.13   | 6.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Ligand Pharmaceuticals Inc.                | Ligand Pharmaceuticals Inc.                                | CUSIP: 53220K504<br>LEI: 5493008K7TB0IKP37H79 | Long             | EC               | CORP              | US        |      1101 | NS      | $218339.31    | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Ardelyx, Inc.                              | Ardelyx, Inc.                                              | CUSIP: 039697107<br>LEI: 549300F542QR4SXHCY32 | Long             | EC               | CORP              | US        |     13580 | NS      | $88949.00     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Amphastar Pharmaceuticals, Inc.            | Amphastar Pharmaceuticals, Inc.                            | CUSIP: 03209R103<br>LEI: 54930055TH0ZLSAQMJ38 | Long             | EC               | CORP              | US        |      2574 | NS      | $52072.02     | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| Ocular Therapeutix, Inc.                   | Ocular Therapeutix, Inc.                                   | CUSIP: 67576A100<br>LEI: 529900ABAWFXOHSIHG03 | Long             | EC               | CORP              | US        |     11885 | NS      | $106251.90    | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| Aurinia Pharmaceuticals Inc.               | Aurinia Pharmaceuticals Inc.                               | CUSIP: 05156V102<br>LEI: 5299008YP2BW4570ML28 | Long             | EC               | CORP              | CA        |      7358 | NS      | $104262.86    | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Xenon Pharmaceuticals Inc.                 | Xenon Pharmaceuticals Inc.                                 | CUSIP: 98420N105<br>LEI: 549300XV44Q9Z1MIPQ03 | Long             | EC               | CORP              | CA        |      4390 | NS      | $189779.70    | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Coherus Oncology, Inc.                     | Coherus Oncology, Inc.                                     | CUSIP: 19249H103<br>LEI: 5493007IL8W5MV932D26 | Long             | EC               | CORP              | US        |      6762 | NS      | $11292.54     | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| ADMA Biologics, Inc.                       | ADMA Biologics, Inc.                                       | CUSIP: 000899104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     13305 | NS      | $207158.85    | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| Vericel Corp.                              | Vericel Corp.                                              | CUSIP: 92346J108<br>LEI: 54930076YM3PLTDR4B91 | Long             | EC               | CORP              | US        |      2833 | NS      | $101081.44    | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Acadia Pharmaceuticals Inc.                | Acadia Pharmaceuticals Inc.                                | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |      9567 | NS      | $234965.52    | 0.31%             |  |  |  | No            |                  1 | On Loan: No      |
| Ascendis Pharma A/S                        | Ascendis Pharma A/S, ADR                                   | CUSIP: 04351P101<br>LEI: 549300B66JN3W3J8GH73 | Long             | EC               | CORP              | DK        |      3474 | NS      | $811179.00    | 1.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Lifecore Biomedical, Inc.                  | Lifecore Biomedical, Inc.                                  | CUSIP: 514766104<br>LEI: 549300EHBZ5OM9ND9O43 | Long             | EC               | CORP              | US        |      2092 | NS      | $15062.40     | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| SIGA Technologies, Inc.                    | SIGA Technologies, Inc.                                    | CUSIP: 826917106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3989 | NS      | $25808.83     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Galapagos N.V.                             | Galapagos N.V., ADR                                        | CUSIP: 36315X101<br>LEI: 549300QKJ78IY0IOV655 | Long             | EC               | CORP              | BE        |       803 | NS      | $27028.98     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Collegium Pharmaceutical, Inc.             | Collegium Pharmaceutical, Inc.                             | CUSIP: 19459J104<br>LEI: 54930049FXZMTLW8D496 | Long             | EC               | CORP              | US        |      1776 | NS      | $74005.92     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Arbutus Biopharma Corp.                    | Arbutus Biopharma Corp.                                    | CUSIP: 03879J100<br>LEI: 25490064CESONAUIAS23 | Long             | EC               | CORP              | CA        |     10743 | NS      | $50062.38     | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| REGENXBIO Inc.                             | REGENXBIO Inc.                                             | CUSIP: 75901B107<br>LEI: 549300EOES47LATSET33 | Long             | EC               | CORP              | US        |      2835 | NS      | $25628.40     | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| Aclaris Therapeutics, Inc.                 | Aclaris Therapeutics, Inc.                                 | CUSIP: 00461U105<br>LEI: 5493000B2LQ9QTW1DF52 | Long             | EC               | CORP              | US        |      6047 | NS      | $17354.89     | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| CytomX Therapeutics, Inc.                  | CytomX Therapeutics, Inc.                                  | CUSIP: 23284F105<br>LEI: 5493004VW2FW0QLL3345 | Long             | EC               | CORP              | US        |      9460 | NS      | $50800.20     | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2026-03-30

**Name of Applicant:** Invesco Exchange-Traded Fund Trust II

**Signature:** Adrien Deberghes

**Name of Signer:** Adrien Deberghes

**Title:** Vice President