# EDGAR Filing Document

**Accession Number:** 0001082038
**File Stem:** 0001193125-25-200962
**Filing Date:** 2025-9
**Character Count:** 19019
**Document Hash:** 77c6a539a553695e7def8f40da74d158
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-25-200962.hdr.sgml**: 20250911

**ACCESSION NUMBER**: 0001193125-25-200962

**CONFORMED SUBMISSION TYPE**: S-8 POS

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20250911

**DATE AS OF CHANGE**: 20250911

**EFFECTIVENESS DATE**: 20250911

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** DURECT CORP
- **CENTRAL INDEX KEY:** 0001082038
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 943297098
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8 POS
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-98939
- **FILM NUMBER:** 251307549

**BUSINESS ADDRESS:**
- **STREET 1:** 10240 BUBB ROAD
- **CITY:** CUPERTINO
- **STATE:** CA
- **ZIP:** 95014
- **BUSINESS PHONE:** 4087771417

**MAIL ADDRESS:**
- **STREET 1:** 10240 BUBB ROAD
- **CITY:** CUPERTINO
- **STATE:** CA
- **ZIP:** 95014

**As filed with the Securities and Exchange Commission on September 11, 2025** 

**Registration No. 333-47400** 

**Registration No. 333-61224** 

**Registration No. 333-76622** 

**Registration No. 333-86110** 

**Registration No. 333-98939** 

**Registration No. 333-108390** 

**Registration No. 333-120405** 

**Registration No. 333-124701** 

**Registration No. 333-126990** 

**Registration No. 333-134200** 

**Registration No. 333-145244** 

**Registration No. 333-152968** 

**Registration No. 333-161025** 

**Registration No. 333-166700** 

**Registration No. 333-170349** 

**Registration No. 333-176113** 

**Registration No. 333-197980** 

**Registration No. 333-206084** 

**Registration No. 333-212842** 

**Registration No. 333-219832** 

**Registration No. 333-226524** 

**Registration No. 333-240326** 

**Registration No. 333-266590** 

**Registration No. 333-273879** 

**Registration No. 333-283231** 

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**WASHINGTON, D.C. 20549** 

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-47400**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-61224**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-76622**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-86110**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-98939**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-108390**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-120405**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-124701**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-126990**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-134200**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-145244**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-152968**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-161025**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-166700**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-170349**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-176113**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-197980**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-206084**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-212842**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-219832**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-226524**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-240326** 

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-266590**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-273879**

**Post-Effective Amendment No. 1 to Form S-8 Registration Statement No. 333-283231**

***UNDER***

***THE SECURITIES ACT OF 1933***

## DURECT CORPORATION
**(Exact name of registrant as specified in its charter)** 

---

| | |
|:---|:---|
| **Delaware** | **94-3297098** |
| **(State or other jurisdiction of**<br> **incorporation or organization)** | **(I.R.S. Employer**<br> **Identification No.)** |

---

**10240 Bubb Road** 

**Cupertino, CA 95014** 

**(408) 777-1417**

**(Address of Principal Executive Offices) (Zip Code)** 

**SOUTHERN BIOSYSTEMS, INC. 1993 STOCK OPTION PLAN** 

**SOUTHERN RESEARCH TECHNOLOGIES, INC. 1995 NONQUALIFIED STOCK OPTION PLAN** 

**DURECT CORPORATION 1998 INCENTIVE STOCK PLAN** 

**DURECT CORPORATION 2000 EMPLOYEE STOCK PURCHASE PLAN, AS AMENDED** 

**DURECT CORPORATION 2000 STOCK PLAN, AS AMENDED** 

**DURECT CORPORATION 2000 DIRECTORS' STOCK OPTION PLAN** 

**(Full titles of the plans)** 

**Timothy M. Papp** 

**Chief Financial Officer** 

**DURECT Corporation** 

**10240 Bubb Road** 

**Cupertino, CA 95014** 

**(408) 777-1417**

**(Name, address, including zip code, and telephone number, including area code, of agent for service)** 

***Copies to:***

**Alison S. Ressler** 

**Sullivan & Cromwell LLP** 

**1888 Century Park East** 

**Los Angeles, CA 90067-1725** 

**Telephone: (310) 712-6630** 

**Scott B. Crofton** 

**Sullivan & Cromwell LLP** 

**125 Broad Street** 

**New York, NY 10004-2498** 

**Telephone: (212) 558-4682**

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☐ | Accelerated filer | ☐ |
| Non-accelerated filer | ☒ | Smaller reporting company | ☒ |
|  |  | Emerging growth company | ☐ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

------

**DEREGISTRATION OF SECURITIES** 

These post-effective amendments (the "***Post-Effective Amendments***"), filed by DURECT Corporation, a Delaware corporation (the "***Company***"), remove from registration all shares of common stock, par value $0.0001 per share, of the Company (the "***Common Stock***") previously registered under the following Registration Statements on Form S-8 filed by the Company (the "***Registration Statements***") with the U.S. Securities and Exchange Commission (the "***SEC***") pertaining to the registration of shares of Common Stock.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-47400, which was previously filed with the SEC
on [October 5, 2000](http://www.sec.gov/Archives/edgar/data/1082038/000101287000005146/0001012870-00-005146-0001.txt) , registering 325,750 shares of Common Stock under the 1998 Incentive Stock Plan, 150,000 shares of Common Stock
under the 2000 Employee Stock Purchase Plan, as amended, 1,179,800 shares of Common Stock under the 2000 Stock Plan, as amended and 300,000 shares of Common Stock under the 2000 Directors' Stock Option Plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-61224, which was previously filed with the SEC
on [May 18, 2001](http://www.sec.gov/Archives/edgar/data/1082038/000102140801501205/ds8.txt) , registering 462,713 shares of Common Stock under the Southern BioSystems, Inc. 1993 Stock Option Plan, 170,207 shares of Common
Stock under the Southern Research Technologies, Inc. 1995 Nonqualified Stock Option Plan, 225,000 shares of Common Stock under the 2000 Employee Stock Purchase Plan, as amended and 2,250,000 shares of Common Stock under the 2000 Stock Plan, as
amended;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-76622, which was previously filed with the SEC
on [January 11, 2002](http://www.sec.gov/Archives/edgar/data/1082038/000101287002000106/ds8.txt) , registering 118,396 shares of Common Stock under the Southern BioSystems, Inc. 1993 Stock Option Plan and 73,402 shares of
Common Stock under the Southern Research Technologies, Inc. 1995 Nonqualified Stock Option Plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-86110, which was previously filed with the SEC
on [April 12, 2002](http://www.sec.gov/Archives/edgar/data/1082038/000101287002001761/ds8.txt) , registering 225,000 shares under the 2000 Employee Stock Purchase Plan, as amended and 2,250,000 shares of Common Stock under the
2000 Stock Plan, as amended;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-98939, which was previously filed with the SEC
on [August 29, 2002](http://www.sec.gov/Archives/edgar/data/1082038/000101287002003649/ds8.htm) , registering 200,000 shares of Common Stock under the 2000 Directors' Stock Option Plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-108390, which was previously filed with the SEC
on [August 29, 2003](http://www.sec.gov/Archives/edgar/data/1082038/000119312503043953/ds8.htm) , registering 2,250,000 shares of Common Stock under the 2000 Stock Plan, as amended;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-120405, which was previously filed with the SEC
on [November 12, 2004](http://www.sec.gov/Archives/edgar/data/1082038/000119312504194932/ds8.htm) , registering 2,250,000 shares of Common Stock under the 2000 Stock Plan, as amended;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-124701, which was previously filed with the SEC
on [May 6, 2005](http://www.sec.gov/Archives/edgar/data/1082038/000119312505099402/ds8.htm) , registering 225,000 shares of Common Stock under the 2000 Employee Stock Purchase Plan, as amended and 2,250,000 shares of Common
Stock under the 2000 Stock Plan, as amended;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-126990, which was previously filed with the SEC
on [July 28, 2005](http://www.sec.gov/Archives/edgar/data/1082038/000119312505151462/ds8.htm) , registering 425,000 shares of Common Stock under the 2000 Directors' Stock Option Plan;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-134200, which was previously filed with the SEC
on [May 17, 2006](http://www.sec.gov/Archives/edgar/data/1082038/000119312506114592/ds8.htm) , registering 225,000 shares of Common Stock under the 2000 Employee Stock Purchase Plan, as amended and 2,250,000 shares of Common
Stock under the 2000 Stock Plan, as amended;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-145244, which was previously filed with the SEC
on [August 8, 2007](http://www.sec.gov/Archives/edgar/data/1082038/000119312507175634/ds8.htm) , registering 225,000 shares of Common Stock under the 2000 Employee Stock Purchase Plan, as amended and 2,250,000 shares of Common
Stock under the 2000 Stock Plan, as amended;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-152968, which was previously filed with the SEC
on [August 12, 2008](http://www.sec.gov/Archives/edgar/data/1082038/000119312508174811/ds8.htm) , registering 225,000 shares of Common Stock under the 2000 Employee Stock Purchase Plan, as amended and 2,250,000 shares of Common
Stock under the 2000 Stock Plan, as amended;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-161025, which was previously filed with the SEC
on [August 4, 2009](http://www.sec.gov/Archives/edgar/data/1082038/000119312509163838/ds8.htm) , registering 225,000 shares of Common Stock under the 2000 Employee Stock Purchase Plan, as amended and 2,250,000 shares of Common
Stock under the 2000 Stock Plan, as amended;

------

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-166700, which was previously filed with the SEC
on [May 10, 2010](http://www.sec.gov/Archives/edgar/data/1082038/000119312510114653/ds8.htm) , registering 225,000 shares of Common Stock under the 2000 Employee Stock Purchase Plan, as amended and 2,250,000 shares of Common
Stock under the 2000 Stock Plan, as amended;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-170349, which was previously filed with the SEC
on [November 4, 2010](http://www.sec.gov/Archives/edgar/data/1082038/000119312510248006/ds8.htm) , registering 250,000 shares of Common Stock under the 2000 Employee Stock Purchase Plan, as amended;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-176113, which was previously filed with the SEC
on [August 5, 2011](http://www.sec.gov/Archives/edgar/data/1082038/000119312511212463/ds8.htm) , registering 5,500,000 shares of Common Stock under the 2000 Stock Plan, as amended;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-197980, which was previously filed with the SEC
on [August 8, 2014](http://www.sec.gov/Archives/edgar/data/1082038/000119312514302841/d771295ds8.htm) , 4,000,000 shares of Common Stock under the 2000 Stock Plan, as amended;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-206084, which was previously filed with the SEC
on [August 4, 2015](http://www.sec.gov/Archives/edgar/data/1082038/000119312515276770/d52731ds8.htm) , registering 350,000 shares of Common Stock under the 2000 Employee Stock Purchase Plan, as amended;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-212842, which was previously filed with the SEC
on [August 2, 2016](http://www.sec.gov/Archives/edgar/data/1082038/000119312516668474/d235717ds8.htm) , registering 5,000,000 shares of Common Stock under the 2000 Stock Plan, as amended;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-219832, which was previously filed with the SEC
on [August 9, 2017](http://www.sec.gov/Archives/edgar/data/1082038/000156459017016984/drrx-s8.htm) , registering 350,000 shares of Common Stock under the 2000 Employee Stock Purchase Plan, as amended;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-226524, which was previously filed with the SEC
on [August 2, 2018](http://www.sec.gov/Archives/edgar/data/1082038/000156459018018944/drrx-s8.htm) , registering 7,500,000 shares of Common Stock under the 2000 Stock Plan, as amended;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-240326, which was previously filed with the SEC
on [August 4, 2020](http://www.sec.gov/Archives/edgar/data/1082038/000156459020035940/drrx-s8.htm) , registering 350,000 shares of Common Stock under the 2000 Employee Stock Purchase Plan, as amended;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-266590, which was previously filed with the SEC
on [August 5, 2022](http://www.sec.gov/Archives/edgar/data/1082038/000156459022028224/drrx-s8.htm) , registering 18,000,000 shares of Common Stock under 2000 Stock Plan, as amended;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-273879, which was previously filed with the SEC
on [August 10, 2023](http://www.sec.gov/Archives/edgar/data/1082038/000095017023041367/drrx-s8-aug_2023.htm) , registering 40,000 shares of Common Stock (after giving effect to the 1-for-10 reverse stock split of the Common Stock occurring on December 5, 2022) under the 2000 Employee Stock Purchase Plan, as amended;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Registration No. 333-283231, which was previously filed with the SEC
on [November 14, 2024](http://www.sec.gov/Archives/edgar/data/1082038/000095017024127075/drrx-s8-nov_2024.htm) , registering 2,000,000 shares of Common Stock (after giving effect to the 1-for-10 reverse stock split of the Common Stock occurring on December 5, 2022) under 2000 Stock Plan, as amended;

The number of shares of Common Stock registered under the Registration Statements set forth above that were filed prior to December 5, 2022 have not been adjusted to reflect the 1-for-10 reverse stock split of the issued and outstanding shares of Common Stock effected by the Company on December 5, 2022.

On July 28, 2025, the Company entered into an Agreement and Plan of Merger (as amended from time to time, the "***Merger Agreement***") with Bausch Health Americas, Inc., a Delaware corporation ("***Parent***"), BHC Lyon Merger Sub, Inc., a Delaware corporation and wholly owned subsidiary of Parent ("***Merger Sub***"), and solely for purposes of Section 6.10 thereof, Bausch Health Companies Inc., a corporation continued under the laws of the Province of British Columbia. On September 11, 2025, pursuant to the Merger Agreement, Merger Sub merged with and into the Company, with the Company surviving as a wholly owned subsidiary of Parent (the "***Merger***").

------

As a result of the Merger, the Company has terminated all offerings of the Company's securities registered pursuant to its existing registration statements under the Securities Act of 1933, as amended, including the Registration Statements. The Company, by filing these Post-Effective Amendments, hereby terminates the effectiveness of the Registration Statements and removes from registration any and all plan interests and any and all securities registered for issuance under the Registration Statements that remain unsold as of the date hereof. This filing is made in accordance with an undertaking made by the Company in each of the Registration Statements to remove from registration by means of a post-effective amendment any securities that had been registered for issuance that remain unsold at the termination of the offering.

------

SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused these Post-Effective Amendments to the Registration Statements on Form S-8 to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Cupertino, State of California on September 11, 2025.

---

| | |
|:---|:---|
| **DURECT CORPORATION** | **DURECT CORPORATION** |
| By: | /s/ Timothy M. Papp |
|  | Name: Timothy M. Papp |
|  | Title: Chief Financial Officer |

---

No other person is required to sign these Post-Effective Amendments in reliance upon Rule 478 under the Securities Act of 1933, as amended.