# EDGAR Filing Document

**Accession Number:** 0001847367
**File Stem:** 0001847367-26-000004
**Filing Date:** 2026-3
**Character Count:** 21994
**Document Hash:** 30101e0f683494aca399d1388787e97f
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001847367-26-000004.hdr.sgml**: 20260319

**ACCESSION NUMBER**: 0001847367-26-000004

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 13

**CONFORMED PERIOD OF REPORT**: 20260319

**ITEM INFORMATION**: Results of Operations and Financial Condition

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20260319

**DATE AS OF CHANGE**: 20260319

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** ALUMIS INC.
- **CENTRAL INDEX KEY:** 0001847367
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-42143
- **FILM NUMBER:** 26774369

**BUSINESS ADDRESS:**
- **STREET 1:** 280 EAST GRAND AVENUE
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080
- **BUSINESS PHONE:** 650-231-6625

**MAIL ADDRESS:**
- **STREET 1:** 280 EAST GRAND AVENUE
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ESKER THERAPEUTICS, INC.
- **DATE OF NAME CHANGE:** 20230427

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** FL2021-001, Inc.
- **DATE OF NAME CHANGE:** 20210222

?xml version='1.0' encoding='ASCII'? Alumis Inc._March 19, 2026

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**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**FORM 8-K**

**CURRENT REPORT**

**Pursuant to Section 13 or 15(d)**

**of the Securities Exchange Act of 1934**

**Date of Report (Date of earliest event reported): March 19, 2026**

## Alumis Inc.
**(Exact name of registrant as specified in its charter)**

---

| | | |
|:---|:---|:---|
| **Delaware** | **001-42143** | **86-1771129** |
| **(State or other jurisdiction**<br>**of incorporation)** | **(Commission**<br>**File Number)** | **(IRS Employer**<br>**Identification No.)** |

---

**280 East Grand Avenue**

**South San Francisco, California 94080**

**(Address of principal executive offices)**

**Registrant's telephone number, including area code: (650) 231-6625**

**N/A**

**(Former name or former address, if changed since last report.)**

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐&nbsp;&nbsp;&nbsp;&nbsp;Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐&nbsp;&nbsp;&nbsp;&nbsp;Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐&nbsp;&nbsp;&nbsp;&nbsp;Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐&nbsp;&nbsp;&nbsp;&nbsp;Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

**Securities registered pursuant to Section 12(b) of the Act:**

---

| | | |
|:---|:---|:---|
| **Title of each class** | **Trading**<br>**Symbol(s)** | **Name of each exchange**<br>**on which registered** |
| Common Stock, $0.0001 par value per share | ALMS | The Nasdaq Global Select Market |

---

Indicate by check mark whether the registrant is an emerging growth company as defined in as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

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**Item 2.02 Results of Operations and Financial Condition.**

On March 19, 2026, Alumis Inc. (the "Company") issued a press release announcing, among other things, its financial results for the year ended December 31, 2025. A copy of the press release is attached hereto as Exhibit 99.1.

All of the information furnished in this Item 2.02 and Exhibit 99.1 of this Current Report on Form 8-K shall not be deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liabilities of that Section, and shall not be incorporated by reference in any filing made by the Company under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such a filing.

**Item 9.01 Financial Statements and Exhibits.**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d)Exhibits.

---

| | |
|:---|:---|
| **Exhibit No.** | **Description** |
| 99.1 | [Press Release, dated March 19, 2026.](alms-20260319xex99d1.htm) |
| 104 | Cover Page Interactive Data File (embedded within the Inline XBRL Document). |

---

**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

---

| | |
|:---|:---|
| **Alumis Inc.** | **Alumis Inc.** |
| By: | /s/ Martin Babler |
|  | Martin Babler |
|  | President and Chief Executive Officer |

---

Dated: March 19, 2026

## Exhibit 99.1

**Exhibit 99.1**

![Graphic](alms-20260319xex99d1001.jpg)

**Alumis Reports Year End 2025 Financial Results and Highlights**

**Recent Achievements**

*– Positive Phase 3 topline results demonstrating envudeucitinib's leading skin clearance, meaningful symptom improvement and a favorable safety profile in patients with moderate-to-severe plaque psoriasis (PsO) –*

*– Plan to submit NDA for envudeucitinib in PsO in 2H 2026 –*

*– Potentially pivotal Phase 2b clinical topline data for envudeucitinib in systemic lupus erythematosus (SLE) anticipated 3Q 2026 –* 

*– Presentation of additional Phase 3 ONWARD1 and ONWARD2 data at AAD 2026 –*

*– Completed an upsized public offering raising $345.1 million in gross proceeds in Jan 2026 –*

SOUTH SAN FRANCISCO, Calif., March 19, 2026 – Alumis Inc. (Nasdaq: ALMS), a late stage biopharma company developing next-generation targeted therapies for patients with immune-mediated diseases, today reported financial results for the year ended December 31, 2025, and highlighted recent achievements and upcoming milestones.

"Alumis concluded a pivotal year marked by strong execution and the Phase 3 clinical validation of envudeucitinib in moderate-to-severe plaque psoriasis, underscoring the promise of TYK2 inhibition and envudeucitinib's highly differentiated clinical profile," said Martin Babler, President and Chief Executive Officer of Alumis. "By maximally inhibiting TYK2 to block both IL-23 and IL-17 pathways, envudeucitinib delivered comprehensive disease control with rapid onset of action, high rates of skin clearance, and meaningful symptom improvements in our Phase 3 ONWARD program that reinforce our conviction in envudeucitinib's potential to transform the psoriasis treatment landscape. We look forward to our clinical topline readout for our potentially pivotal LUMUS Phase 2b trial in SLE, anticipated in the third quarter of this year."

Babler added, "Importantly, the results of both psoriasis and SLE will potentially unlock envudeucitinib's pipeline-in-a-pill' opportunity to leverage maximal TYK2 inhibition across multiple immune-mediated diseases. Alumis is evaluating additional indications for our TYK2 inhibitors as part of a unified franchise development strategy that we plan to announce in the second quarter of 2026."

**Fourth Quarter 2025 and Recent Highlights**

&nbsp;&nbsp;&nbsp;&nbsp;● **Positive topline results from Phase 3 ONWARD1 and ONWARD2 clinical trials of envudeucitinib, a next-generation highly selective oral tyrosine kinase 2 (TYK2) inhibitor, in patients with moderate-to-severe plaque psoriasis** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Both Phase 3 trials met all primary and secondary endpoints with high statistical significance in patients with moderate-to-severe plaque psoriasis

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Envudeucitinib showed leading skin clearance for oral plaque psoriasis therapies, with approximately 65% of patients achieving PASI 90 and more than 40% achieving PASI 100 at Week 24, on average

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Envudeucitinib demonstrated a favorable safety and tolerability profile consistent with the Phase 2 program

&nbsp;&nbsp;&nbsp;&nbsp;● **Completed closing of its upsized underwritten public offering of 20,297,500 shares of its common stock, including the full exercise of the underwriters' option to purchase an additional 2,647,500 shares, at a price to the public of $17.00 per share** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Gross proceeds to Alumis from the offering, before deducting underwriting discounts and commissions and offering expenses, were approximately $345.1 million

&nbsp;&nbsp;&nbsp;&nbsp;● **TYK2 Pipeline Update** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Given the strength and insights from the Phase 3 envudeucitinib data in PsO and the Phase 2 readiness of A 005, Alumis is well-positioned to expand the potential of its TYK2 pipeline.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Alumis is currently evaluating additional immune mediated disease indications for envudeucitinib beyond PsO and SLE, and for its A 005 program in central nervous system (CNS) and peripheral diseases, under a unified TYK2 franchise development strategy.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Alumis will provide an update of the TYK2 franchise strategy for both programs in the second quarter of 2026, including a timing update for commencing A-005's Phase 2 trial.

**Anticipated 2026 Milestones**

&nbsp;&nbsp;&nbsp;&nbsp;● **Envudeucitinib in Moderate-to-Severe Plaque Psoriasis** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Late-breaking oral presentation of additional Phase 3 data (ONWARD1 and ONWARD2) at the American Academy of Dermatology (AAD) Annual Meeting taking place March 27-31 in Denver, CO

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Company management to participate in a virtual key opinion leader (KOL) event featuring leading dermatology and psoriasis expert Dr. Andrew Blauvelt, to discuss results from the Phase 3 ONWARD program that were presented at AAD

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Long-term data - ONWARD3 topline data and Phase 2, two-year safety data (2H 2026)

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o NDA submission (2H2026)

&nbsp;&nbsp;&nbsp;&nbsp;● **Envudeucitinib in SLE** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Potentially pivotal Phase 2b SLE topline data (3Q 2026)

&nbsp;&nbsp;&nbsp;&nbsp;● **TYK2 Franchise** 

● Update on unified TYK2 franchise development strategy, including evaluation of additional indications (2Q 2026)

&nbsp;&nbsp;&nbsp;&nbsp;● **Lonigutamab** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Completion of strategic review (1H 2026)

&nbsp;&nbsp;&nbsp;&nbsp;● **Next clinical candidate (new target)** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;o Initiate Phase 1 trial (2H 2026)

------

**Year-end 2025 Financial Results**

● As of December 31, 2025, Alumis had cash, cash equivalents and marketable securities of $308.5 million.

● Revenue included license revenue of $17.4 million and collaboration revenue of $6.7 million for the year ended December 31, 2025, related to the collaboration and licensing agreement with Kaken Pharmaceutical Co., Ltd.

● Research and development expenses were $386.0 million for the year ended December 31, 2025, compared to $265.6 million for the year ended December 31, 2024. The increase was primarily driven by contract research and clinical trial costs for the envudeucitinib and other programs, including costs to support acceleration of clinical trial activities for the Phase 3 ONWARD clinical program, as well as increased headcount to support development eﬀorts and severance costs, including stock-based compensation expense, related to the merger with ACELYRIN. The year ended December 31, 2024 included a clinical milestone payment of $23.0 million related to the prior acquisition of FronThera.

● General and administrative expenses were $91.9 million for the year ended December 31, 2025, compared to $35.2 million for the year ended December 31, 2024. The increase was primarily attributable to transaction and severance costs, including stock-based compensation expense, related to the merger with ACELYRIN, as well as increased headcount and professional consulting services to support the Company's growth.

● Net loss was $243.3 million for the year ended December 31, 2025, compared to a net loss of $294.2 million for the year ended December 31, 2024.

● The Company recognized total expenses related to the merger with ACELYRIN of $39.7 million for the year ended December 31, 2025, of which $30.2 million related to general and administrative expenses for the year ended December 31, 2025, and $9.5 million related to research and development expenses for the year ended December 31, 2025. These merger-related expenses included stock-based compensation expense of $13.1 million for the year ended December 31, 2025, related to accelerated vesting of equity awards and a stock option post-termination exercise period modification for severed employees.

**Financial Guidance**

● Based on the Company's current operating plan, Alumis continues to anticipate that its existing cash, cash equivalents and marketable securities as of December 31, 2025, as well as net proceeds of $324.4 million, after underwriting discounts and commissions, from its public offering of common stock in January 2026, is expected to fund operating expenses and capital expenditure requirements into the fourth quarter of 2027.

**About Alumis** 

Alumis is a late-stage biopharma company developing next-generation targeted therapies with the potential to significantly improve patient health and outcomes across a range of immune-mediated diseases. Leveraging its proprietary data analytics platform and precision approach, Alumis is developing a pipeline of oral tyrosine kinase 2 inhibitors, consisting of envudeucitinib, formerly known as ESK-001, for the treatment of systemic immune-mediated disorders, such as moderate-to-severe plaque psoriasis and systemic lupus erythematosus, and A-005 with neuroinflammatory, neurodegenerative and peripheral immune-mediated disease indications under evaluation. In addition, the pipeline includes lonigutamab, a subcutaneously delivered anti–insulin-like growth factor 1 receptor therapy for the treatment of thyroid eye disease, as well as several preclinical programs identified through this precision approach. For more information, visit www.alumis.com or follow us on LinkedIn or X.

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**Forward-Looking Statements**

This press release contains forward-looking statements within the meaning of federal securities laws, including the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. These statements may be identified by words such as "anticipates," "believes,", "plans," "seeks," "will" and variations of these words or similar expressions that are intended to identify forward-looking statements. All statements, other than statements of historical facts, including without limitation those regarding the timing of the initiation of a clinical trial, or the timing of clinical data in its ongoing clinical trials, the timing of the Company's planned NDA submission with the FDA for envudeucitinib in moderate-to-severe plaque psoriasis, the expected timing of each of the Company's completion of its strategic review for lonigutamab, determination of its next clinical candidate and presentation of its TYK2 franchise strategy, the potential for envudeucitinib to treat moderate-to-severe plaque psoriasis and systemic lupus erythematosus, any expectations regarding the safety, efficacy or tolerability of its drug candidates and statements regarding Alumis' future plans and prospects, including development of its clinical pipeline and the commencement of additional clinical trials; cash runway; Alumis' participation at upcoming conferences, and any assumptions underlying any of the foregoing, are forward-looking statements. Forward-looking statements in this press release are based on Alumis' current expectations, estimates and projections as of the date of this release and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely and readers are cautioned that actual results, levels of activity, safety, efficacy, performance or events and circumstances could differ materially from those expressed or implied in Alumis' forward-looking statements. Such risks and uncertainties include, without limitation, those related to Alumis' ability to advance envudeucitinib or its other programs and to obtain regulatory approval of and ultimately commercialize Alumis' clinical candidates, the timing, costs, and results of preclinical and clinical trials, Alumis' ability to fund development activities and achieve development goals, Alumis' ability to protect its intellectual property and other risks and uncertainties described in Alumis' filings with the Securities and Exchange Commission (SEC). Alumis explicitly disclaims any obligation to update any forward-looking statements except to the extent required by law.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;

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**ALUMIS INC.**

**CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS**

**(Unaudited)**

---

| | | |
|:---|:---|:---|
| | **Year Ended December 31,**  | **Year Ended December 31,**  |
| <br>**(in thousands)** | **2025** | **2024** |
| Revenue: |  |  |
| &nbsp;&nbsp;License revenue | $17389 | $— |
| &nbsp;&nbsp;Collaboration revenue | 6661 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Total revenue | 24050 |  |
| Operating expenses: |  |  |
| &nbsp;&nbsp;Research and development expenses | 385998 | 265554 |
| &nbsp;&nbsp;General and administrative expenses | 91856 | 35200 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total operating expenses | 477854 | 300754 |
| Loss from operations | (453804) | (300754) |
| Other income (expense): |  |  |
| &nbsp;&nbsp;Gain on bargain purchase | 187907 |  |
| &nbsp;&nbsp;Interest income | 14180 | 12020 |
| &nbsp;&nbsp;Change in fair value of derivative liability |  | (5406) |
| &nbsp;&nbsp;Other income (expenses), net | (169) | (93) |
| &nbsp;&nbsp;&nbsp;&nbsp;Total other income (expense), net | 201918 | 6521 |
| Net loss before income taxes | (251886) | (294233) |
| &nbsp;&nbsp;&nbsp;&nbsp;Income tax benefit | 8561 |  |
| Net loss | $(243325) | $(294233) |
| Other comprehensive income (loss): |  |  |
| &nbsp;&nbsp;Unrealized gain (loss) on marketable securities, net | 148 | 38 |
| Total comprehensive loss | $(243177) | $(294195) |

---

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**ALUMIS INC.**

**CONSOLIDATED BALANCE SHEETS**

**(Unaudited)**

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| | | |
|:---|:---|:---|
| <br>**(in thousands)** | **December 31,** <br>**2025** | **December 31,**<br>**2024** |
| **Assets** |  |  |
| Current assets: |  |  |
| &nbsp;&nbsp;Cash and cash equivalents | $89670 | $169526 |
| &nbsp;&nbsp;Restricted cash | 82 |  |
| &nbsp;&nbsp;Marketable securities | 218831 | 118737 |
| &nbsp;&nbsp;Research and development prepaid expenses | 2909 | 13424 |
| &nbsp;&nbsp;Other prepaid expenses and current assets | 6740 | 4501 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total current assets | 318232 | 306188 |
| Restricted cash, non-current | 1301 | 1106 |
| Property and equipment, net | 18190 | 20968 |
| Intangible assets | 50959 |  |
| Operating lease right-of-use assets, net | 16971 | 12723 |
| Other assets, non-current | 6287 | 7 |
| &nbsp;&nbsp;Total assets | $411940 | $340992 |
| **Liabilities and Stockholders' Equity** |  |  |
| Current liabilities: |  |  |
| &nbsp;&nbsp;Accounts payable | $10106 | $9624 |
| &nbsp;&nbsp;Research and development accrued expenses | 34781 | 29149 |
| &nbsp;&nbsp;Deferred revenue, current | 1458 |  |
| &nbsp;&nbsp;Other accrued expenses and current liabilities | 22303 | 10580 |
| &nbsp;&nbsp;Operating lease liabilities, current | 4670 | 1557 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total current liabilities | 73318 | 50910 |
| Operating lease liabilities, non-current | 32244 | 29165 |
| Deferred revenue, non-current | 2611 |  |
| Deferred tax liability | 2140 |  |
| Share repurchase liability | 123 | 813 |
| Other liabilities, non-current | 207 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Total liabilities | 110643 | 80888 |
| Stockholders' equity: |  |  |
| &nbsp;&nbsp;Preferred stock |  |  |
| &nbsp;&nbsp;Common stock | 10 | 5 |
| &nbsp;&nbsp;Additional paid-in capital | 1202975 | 918610 |
| &nbsp;&nbsp;Accumulated other comprehensive income (loss) | 188 | 40 |
| &nbsp;&nbsp;Accumulated deficit | (901876) | (658551) |
| &nbsp;&nbsp;&nbsp;&nbsp;Total stockholders' equity | 301297 | 260104 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total liabilities and stockholders' equity | $411940 | $340992 |

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**Alumis Contact Information**

Teri Dahlman

Red House Communications

<u>teri@redhousecomms.com</u>

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