# EDGAR Filing Document

**Accession Number:** 0001346824
**File Stem:** 0001104659-23-021847
**Filing Date:** 2023-2
**Character Count:** 11936
**Document Hash:** 4402c250f81603b99a2b29305c949b86
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-23-021847.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001104659-23-021847

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**EFFECTIVENESS DATE**: 20230214

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** RA CAPITAL MANAGEMENT, L.P.
- **CENTRAL INDEX KEY:** 0001346824
- **IRS NUMBER:** 830406777
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-12884
- **FILM NUMBER:** 23630846

**BUSINESS ADDRESS:**
- **STREET 1:** 200 BERKELEY STREET, 18TH FLOOR
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02116
- **BUSINESS PHONE:** 617-778-2500

**MAIL ADDRESS:**
- **STREET 1:** 200 BERKELEY STREET, 18TH FLOOR
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02116

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** RA CAPITAL MANAGEMENT, LLC
- **DATE OF NAME CHANGE:** 20051213

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2022

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** RA CAPITAL MANAGEMENT L.P.<br>**Address:** 200 Berkeley Street 18th Floor<br>Boston, MA 02116

**Form 13F File Number:** 028-12884

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Rajeev Shah<br>**Title:** Authorized Signatory<br>**Phone:** 617-778-2500

**Signature, Place, and Date of Signing:**

/s/ Rajeev Shah  Boston, MA  02-14-2023<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 70

**Form 13F Information Table Value Total:** $4930699654

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| 89BIO INC | COM | 282559103 | BBG00QKDZ8J5 | 114002369 | 8955410 | SH |  | SOLE |  | 8955410 | 0 | 0 |
| AADI BIOSCIENCE INC | COM | 00032Q104 | BBG002WN7DT2 | 7572497 | 590218 | SH |  | SOLE |  | 590218 | 0 | 0 |
| ACHILLES THERAPEUTICS PLC | SPONSORED ADS | 00449L102 | BBG00ZHF9VV8 | 1447051 | 1607834 | SH |  | SOLE |  | 1607834 | 0 | 0 |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | BBG003LF0QR9 | 69275635 | 4398453 | SH |  | SOLE |  | 4398453 | 0 | 0 |
| ACRIVON THERAPEUTICS INC | COMMON STOCK | 004890109 | BBG011RWR2Q4 | 55417052 | 4810508 | SH |  | SOLE |  | 4810508 | 0 | 0 |
| ACUMEN PHARMACEUTICALS INC | COM | 00509G209 | BBG0058YJ317 | 52762174 | 9770773 | SH |  | SOLE |  | 9770773 | 0 | 0 |
| AEROVATE THERAPEUTICS INC | COM | 008064107 | BBG00WGHZFH4 | 242134673 | 8263982 | SH |  | SOLE |  | 8263982 | 0 | 0 |
| AKERO THERAPEUTICS INC | COM | 00973Y108 | BBG00L9211Y8 | 52552104 | 958980 | SH |  | SOLE |  | 958980 | 0 | 0 |
| ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | BBG001J2LL66 | 32320655 | 4397368 | SH |  | SOLE |  | 4397368 | 0 | 0 |
| AN2 THERAPEUTICS INC | COM | 037326105 | BBG00QYLYBK4 | 35961617 | 3773517 | SH |  | SOLE |  | 3773517 | 0 | 0 |
| ARS PHARMACEUTICALS INC | COM | 82835W108 | BBG00FZQGXG3 | 25672553 | 3009678 | SH |  | SOLE |  | 3009678 | 0 | 0 |
| ARYA SCIENCES ACQUISITN CORP | CLASS A ORD SHS | G31658100 | BBG011LN0VR4 | 10090000 | 1000000 | SH |  | SOLE |  | 1000000 | 0 | 0 |
| ASCENDIS PHARMA A/S | SPONSORED ADR | 04351P101 | BBG007R7VNC1 | 849680271 | 6957179 | SH |  | SOLE |  | 6957179 | 0 | 0 |
| ATHIRA PHARMA INC | COM | 04746L104 | BBG00C77LX40 | 5963721 | 1881300 | SH |  | SOLE |  | 1881300 | 0 | 0 |
| AVIDITY BIOSCIENCES INC | COM | 05370A108 | BBG00FQ7LXW1 | 121036087 | 5454533 | SH |  | SOLE |  | 5454533 | 0 | 0 |
| BELLUS HEALTH INC NEW | COM NEW | 07987C204 | BBG000CKVYZ4 | 102360158 | 12452574 | SH |  | SOLE |  | 12452574 | 0 | 0 |
| BIOGEN INC | COM | 09062X103 | BBG000C17X76 | 147568453 | 532892 | SH |  | SOLE |  | 532892 | 0 | 0 |
| BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | BBG00MS4Y0W9 | 4661827 | 2589904 | SH |  | SOLE |  | 2589904 | 0 | 0 |
| CELCUITY INC | COM | 15102K100 | BBG00HKBW045 | 19614014 | 1400001 | SH |  | SOLE |  | 1400001 | 0 | 0 |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | BBG000FW8LZ9 | 92482750 | 2075000 | SH |  | SOLE |  | 2075000 | 0 | 0 |
| COGENT COMMUNICATIONS HLDGS | COM NEW | 19240Q201 | BBG007DHZQR7 | 69354000 | 5999481 | SH |  | SOLE |  | 5999481 | 0 | 0 |
| CONCERT PHARMACEUTICALS INC | COM | 206022105 | BBG001RY41W1 | 6355649 | 1088296 | SH |  | SOLE |  | 1088296 | 0 | 0 |
| CONNECT BIOPHARMA HLDGS LTD | ADS | 207523101 | BBG00ZGYNJ49 | 6066792 | 6991003 | SH |  | SOLE |  | 6991003 | 0 | 0 |
| CVRX INC | COM | 126638105 | BBG001B56NX0 | 5046250 | 275000 | SH |  | SOLE |  | 275000 | 0 | 0 |
| CYTEK BIOSCIENCES INC | COM | 23285D109 | BBG00D36Q0Z7 | 136620561 | 13381054 | SH |  | SOLE |  | 13381054 | 0 | 0 |
| DA32 LIFE SCNCE | CLASS A COM | 23312M106 | BBG011PFN2X9 | 14992500 | 1500000 | SH |  | SOLE |  | 1500000 | 0 | 0 |
| DAY ONE BIOPHARMACEUTICALS I | COM | 23954D109 | BBG00V1KSN04 | 151514185 | 7040622 | SH |  | SOLE |  | 7040622 | 0 | 0 |
| DBV TECHNOLOGIES S A | SPONSORED ADR | 23306J101 | BBG0076D3T39 | 2997204 | 1958957 | SH |  | SOLE |  | 1958957 | 0 | 0 |
| DESIGN THERAPEUTICS INC | COM | 25056L103 | BBG00SNC49V8 | 30484830 | 2971231 | SH |  | SOLE |  | 2971231 | 0 | 0 |
| DICE THERAPEUTICS INC | COM | 23345J104 | BBG00WLPGWQ4 | 213686023 | 6848911 | SH |  | SOLE |  | 6848911 | 0 | 0 |
| ELIEM THERAPEUTICS INC | COM | 28658R106 | BBG00ZNKL0K6 | 48263616 | 13150849 | SH |  | SOLE |  | 13150849 | 0 | 0 |
| ENTERA BIO LTD | SHS | M40527109 | BBG000R1K184 | 216055 | 295966 | SH |  | SOLE |  | 295966 | 0 | 0 |
| EYEPOINT PHARMACEUTICALS INC | COM NEW | 30233G209 | BBG000F90JX5 | 11796771 | 3370506 | SH |  | SOLE |  | 3370506 | 0 | 0 |
| FULCRUM THERAPEUTICS INC | COM | 359616109 | BBG00DDY1RK9 | 69203134 | 9505925 | SH |  | SOLE |  | 9505925 | 0 | 0 |
| FUSION PHARMACEUTICALS INC | COM | 36118A100 | BBG00V9VQ3R9 | 2078975 | 659992 | SH |  | SOLE |  | 659992 | 0 | 0 |
| GERON CORP | COM | 374163103 | BBG000GX1891 | 31292321 | 12930711 | SH |  | SOLE |  | 12930711 | 0 | 0 |
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 | BBG011BQC379 | 47612186 | 4898373 | SH |  | SOLE |  | 4898373 | 0 | 0 |
| HEALTH SCIENCES ACQ CORP 2 | ORD SHS | G4411D109 | BBG00W5FR2T5 | 6090624 | 610283 | SH |  | SOLE |  | 610283 | 0 | 0 |
| HILLEVAX INC | COM | 43157M102 | BBG012FCPWH5 | 29445118 | 1760019 | SH |  | SOLE |  | 1760019 | 0 | 0 |
| ICOSAVAX INC | COM | 45114M109 | BBG00QHK2J87 | 47350706 | 5963565 | SH |  | SOLE |  | 5963565 | 0 | 0 |
| IMARA INC | COM | 45249V107 | BBG00CP3BDD4 | 13295461 | 3250724 | SH |  | SOLE |  | 3250724 | 0 | 0 |
| IMMUNIC INC | COM | 4525EP101 | BBG001M75SX4 | 885058 | 632184 | SH |  | SOLE |  | 632184 | 0 | 0 |
| IMMUNOGEN INC | COM | 45253H101 | BBG000C2JTB5 | 108395632 | 21853958 | SH |  | SOLE |  | 21853958 | 0 | 0 |
| INHIBRX INC | COM | 45720L107 | BBG00P80N9T9 | 94959283 | 3853867 | SH |  | SOLE |  | 3853867 | 0 | 0 |
| IO BIOTECH INC | COM | 449778109 | BBG0131XRY31 | 2592698 | 1127260 | SH |  | SOLE |  | 1127260 | 0 | 0 |
| ITEOS THERAPEUTICS INC | COM | 46565G104 | BBG00VPNFSJ5 | 86269068 | 4417259 | SH |  | SOLE |  | 4417259 | 0 | 0 |
| JANUX THERAPEUTICS INC | COM | 47103J105 | BBG00ZHSKH11 | 114192381 | 8670644 | SH |  | SOLE |  | 8670644 | 0 | 0 |
| KINNATE BIOPHARMA INC | COM | 49705R105 | BBG00R4SGVG1 | 26011278 | 4264144 | SH |  | SOLE |  | 4264144 | 0 | 0 |
| LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 | BBG00TTGH5W4 | 121616252 | 2436223 | SH |  | SOLE |  | 2436223 | 0 | 0 |
| NANOSTRING TECHNOLOGIES | COM | 63009R109 | BBG0019K7GX4 | 1146883 | 143900 | SH |  | SOLE |  | 143900 | 0 | 0 |
| NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | N62509109 | BBG01BNNTQN4 | 43600000 | 4000000 | SH |  | SOLE |  | 4000000 | 0 | 0 |
| NKARTA INC | COM | 65487U108 | BBG00JXHS9G7 | 46752723 | 7805129 | SH |  | SOLE |  | 7805129 | 0 | 0 |
| PEPGEN INC | COM | 713317105 | BBG012232618 | 108724198 | 8131952 | SH |  | SOLE |  | 8131952 | 0 | 0 |
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | BBG007DLZ601 | 160627871 | 5516067 | SH |  | SOLE |  | 5516067 | 0 | 0 |
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 | BBG000WG3567 | 47107906 | 2407149 | SH |  | SOLE |  | 2407149 | 0 | 0 |
| RXSIGHT INC | COM | 78349D107 | BBG00THX1YN4 | 38678925 | 3052796 | SH |  | SOLE |  | 3052796 | 0 | 0 |
| SATSUMA PHARMACEUTICALS INC | COM | 80405P107 | BBG00FLQP542 | 5322827 | 5914252 | SH |  | SOLE |  | 5914252 | 0 | 0 |
| SCPHARMACEUTICALS INC | COM | 810648105 | BBG00J24RT13 | 13314002 | 1856904 | SH |  | SOLE |  | 1856904 | 0 | 0 |
| SOLID BIOSCIENCES INC | COM | 83422E204 | BBG00JN4FXG8 | 18433419 | 3426286 | SH |  | SOLE |  | 3426286 | 0 | 0 |
| TENAYA THERAPEUTICS INC | COM | 87990A106 | BBG00FPMK2S3 | 12195641 | 6067483 | SH |  | SOLE |  | 6067483 | 0 | 0 |
| THIRD HARMONIC BIO INC | COM | 88427A107 | BBG00Z14GXB0 | 2299154 | 534687 | SH |  | SOLE |  | 534687 | 0 | 0 |
| TRAVERE THERAPEUTICS INC | COM | 89422G107 | BBG000P9D6W9 | 83797841 | 3984681 | SH |  | SOLE |  | 3984681 | 0 | 0 |
| TYRA BIOSCIENCES INC | COM | 90240B106 | BBG00RCQD9D1 | 54997050 | 7236454 | SH |  | SOLE |  | 7236454 | 0 | 0 |
| VAXCYTE INC | COM | 92243G108 | BBG009PHHPL8 | 280865159 | 5857459 | SH |  | SOLE |  | 5857459 | 0 | 0 |
| VERONA PHARMA PLC | SPONSORED ADS | 925050106 | BBG00GD4KBL1 | 165089079 | 6317990 | SH |  | SOLE |  | 6317990 | 0 | 0 |
| VIRIDIAN THERAPEUTICS INC | SPONSORED ADS | 92790C104 | BBG002H242Z5 | 25704800 | 880000 | SH |  | SOLE |  | 880000 | 0 | 0 |
| VOR BIOPHARMA INC | COM | 929033108 | BBG00NBJRDT6 | 151280052 | 22748880 | SH |  | SOLE |  | 22748880 | 0 | 0 |
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 | BBG00B642V54 | 120414063 | 17202009 | SH |  | SOLE |  | 17202009 | 0 | 0 |
| WEREWOLF THERAPEUTICS INC | COM | 95075A107 | BBG00QXQ9XK4 | 8798356 | 4291881 | SH |  | SOLE |  | 4291881 | 0 | 0 |
| NEWAMSTERDAM PHARMA COMPANY | *W EXP 11/22/202 | N62509117 | BBG01BNP2MK0 | 289433 | 333333 | SH |  | SOLE |  | 333333 | 0 | 0 |

---