# EDGAR Filing Document

**Accession Number:** 0001819113
**File Stem:** 0001104659-23-031039
**Filing Date:** 2023-3
**Character Count:** 2524
**Document Hash:** a54aca8d57e3e1d44fbe206b592cd52f
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-23-031039.hdr.sgml**: 20230411

**ACCESSION NUMBER**: 0001104659-23-031039

**CONFORMED SUBMISSION TYPE**: CORRESP

**PUBLIC DOCUMENT COUNT**: 2

**FILED AS OF DATE**: 20230310

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Science 37 Holdings, Inc.
- **CENTRAL INDEX KEY:** 0001819113
- **STANDARD INDUSTRIAL CLASSIFICATION:** SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
- **IRS NUMBER:** 844278203
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** CORRESP

**BUSINESS ADDRESS:**
- **STREET 1:** 800 PARK OFFICES DRIVE
- **STREET 2:** SUITE 3606
- **CITY:** RESEARCH TRIANGLE PARK
- **STATE:** NC
- **ZIP:** 27709
- **BUSINESS PHONE:** (984) 377-3737

**MAIL ADDRESS:**
- **STREET 1:** 800 PARK OFFICES DRIVE
- **STREET 2:** SUITE 3606
- **CITY:** RESEARCH TRIANGLE PARK
- **STATE:** NC
- **ZIP:** 27709

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Lifesci Acquisition II Corp.
- **DATE OF NAME CHANGE:** 20200723

![](tm239161d1_correspimg001.jpg)

March 10, 2023

**<u>VIA EDGAR SUBMISSION</u>**

U.S. Securities and Exchange Commission<br> Division of Corporation Finance<br> 100 F Street, N.E.<br> Washington, D.C. 20549

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| | |
|:---|:---|
| **Re:** | **Science 37 Holdings, Inc. (the "*Company*")<br> Registration Statement on Form S-3 (File No. 333-270285) (the "*Registration Statement*")** |

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Dear Ladies and Gentlemen:

Pursuant to Rule 461 of the Securities Act of 1933, as amended (the "*Securities Act"),* the Company hereby requests that the Securities and Exchange Commission (the "*Commission*") take appropriate action to cause the above-referenced Registration Statement to become effective on Monday, March 13, 2023, at 4:00 p.m., Eastern Time, or as soon thereafter as is practicable, unless the Company notifies you otherwise prior to such time.

If you have any questions regarding this request, please contact our outside counsel, Jurgita Ashley of Thompson Hine LLP, at (330) 819-1221 or via <u>Jurgita.Ashley@ThompsonHine.com</u>. Please also call Jurgita Ashley as soon as the Company's Registration Statement has been declared effective. Thank you for your attention to this matter.

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| | |
|:---|:---|
| Sincerely, | Sincerely, |
| **SCIENCE 37 HOLDINGS, INC.** | **SCIENCE 37 HOLDINGS, INC.** |
| By: | /s/ Christine Pellizzari |
| Name: | Christine Pellizzari |
| Title: | Chief Legal and Human Resources Officer |

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cc: Jurgita Ashley, Thompson Hine LLP