# EDGAR Filing Document

**Accession Number:** 0000899923
**File Stem:** 0000899923-23-000008
**Filing Date:** 2023-2
**Character Count:** 59561
**Document Hash:** 319d27dd4ba9d9a02b2d51522205b23a
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000899923-23-000008.hdr.sgml**: 20230228

**ACCESSION NUMBER**: 0000899923-23-000008

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 13

**CONFORMED PERIOD OF REPORT**: 20230228

**ITEM INFORMATION**: Results of Operations and Financial Condition

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20230228

**DATE AS OF CHANGE**: 20230228

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** MYRIAD GENETICS INC
- **CENTRAL INDEX KEY:** 0000899923
- **STANDARD INDUSTRIAL CLASSIFICATION:** IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835]
- **IRS NUMBER:** 870494517
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 000-26642
- **FILM NUMBER:** 23685123

**BUSINESS ADDRESS:**
- **STREET 1:** 320 WAKARA WAY
- **CITY:** SALT LAKE CITY
- **STATE:** UT
- **ZIP:** 84108
- **BUSINESS PHONE:** 801-584-3600

**MAIL ADDRESS:**
- **STREET 1:** 320 WAKARA WAY
- **CITY:** SALT LAKE CITY
- **STATE:** UT
- **ZIP:** 84108

?xml version="1.0" ? mygn-20230228

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**FORM 8-K**

**CURRENT REPORT**

**Pursuant to Section 13 or 15(d)**

**of the Securities Exchange Act of 1934**

**Date of Report (Date of earliest event reported): February 28, 2023**

**MYRIAD GENETICS, INC.**

**(Exact name of registrant as specified in its charter)**

---

| | | |
|:---|:---|:---|
| **Delaware** | **0-26642** | **87-0494517** |
| **(State or other jurisdiction of<br>incorporation)** | **(Commission<br>File Number)** | **(IRS Employer<br>Identification No.)** |

---

**320 Wakara Way**

**Salt Lake City, Utah 84108**

**(Address of principal executive offices) (Zip Code)**

**Registrant's telephone number, including area code: (801) 584-3600**

**Not Applicable**

**(Former name or former address, if changed since last report)**

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

---

| | | |
|:---|:---|:---|
| **Title of each class** | **Trading<br>Symbol(s)** | **Name of each exchange on which registered** |
| Common Stock, $0.01 par value | MYGN | Nasdaq Global Select Market |

---

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

------

**ITEM 2.02&nbsp;&nbsp;&nbsp;&nbsp;Results of Operations and Financial Condition.**

On February 28, 2023, Myriad Genetics, Inc. (the "company") announced its financial results for the three months ended December 31, 2022. The earnings release is attached hereto as Exhibit 99.1 to this Current Report on Form 8-K and incorporated herein by reference.

**FORWARD-LOOKING STATEMENTS**

Exhibit 99.1 contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, including the company's fiscal year 2023 and first quarter 2023 financial guidance, and statements relating to the company's continuing investment in its laboratories of the future strategy and enabling technologies, the company's plans to introduce a number of new products in the second half of 2023, including Precise Liquid and FirstGene, the company's goal of achieving 10%+ annual revenue growth by 2024, the planned roll out of the unified ordering portal through 2023, the phased roll out of the Epic EMR integration through 2023 and beyond, and the company's expectation that both new facility construction and related developments and capital expenditure targets will be substantially completed in 2023. These "forward-looking statements" are management's present expectations of future events as of the date hereof and are subject to a number of known and unknown risks and uncertainties that could cause actual results, conditions, and events to differ materially and adversely from those anticipated. These risks include, but are not limited to: the risk that sales and profit margins of the company's existing tests may decline or that the company may not be able to operate its business on a profitable basis; risks related to the company's ability to achieve certain revenue growth targets and generate sufficient revenue from its existing product portfolio or in launching and commercializing new tests to be profitable; risks related to changes in governmental or private insurers' coverage and reimbursement levels for the company's tests or the company's ability to obtain reimbursement for its new tests at comparable levels to its existing tests; risks related to increased competition and the development of new competing tests; continued uncertainties associated with COVID-19, including its possible effects on the company's operations and the demand for its products; the risk that the company may be unable to develop or achieve commercial success for additional tests in a timely manner, or at all; the risk that the company may not successfully develop new markets or channels for its tests, including the company's ability to successfully generate substantial revenue outside the United States; the risk that licenses to the technology underlying the company's tests and any future tests are terminated or cannot be maintained on satisfactory terms; risks related to delays or other problems with constructing and operating the company's laboratory testing facilities; risks related to public concern over genetic testing in general or the company's tests in particular; risks related to regulatory requirements or enforcement in the United States and foreign countries and changes in the structure of the healthcare system or healthcare payment systems; risks related to the company's ability to obtain new corporate collaborations or licenses and acquire or develop new technologies or businesses on satisfactory terms, if at all; risks related to the company's ability to successfully integrate and derive benefits from any technologies or businesses that it licenses, acquires or develops; the risk that the company is not able to secure additional financing to fund its business, if needed, in a timely manner or on favorable terms, if it all; risks related to the company's projections about the potential market opportunity for the company's current and future products; the risk that the company or its licensors may be unable to protect or that third parties will infringe the proprietary technologies underlying the company's tests; the risk of patent-infringement claims or challenges to the validity of the company's patents; risks related to changes in intellectual property laws covering the company's tests, or patents or enforcement, in the United States and foreign countries; risks related to security breaches, loss of data and other disruptions, including from cyberattacks; risks of new, changing and competitive technologies in the United States and internationally and that the company may not be able to keep pace with the rapid technology changes in its industry, or properly leverage new technologies to achieve or sustain competitive advantages in its products; the risk that the company may be unable to comply with financial operating covenants under the company's credit or lending agreements; risks related to the company's inability to achieve and maintain effective disclosure controls and procedures and internal control over financial reporting; risks related to current and future investigations, claims or lawsuits, including derivative claims, product or professional liability claims, and risks related to the amount of the company's insurance coverage limits and scope of insurance coverage with respect thereto; and other factors discussed under the heading "Risk Factors" contained in Item 1A of the company's Annual Report on Form 10-K filed with the U.S. Securities and Exchange Commission on February 25, 2022, as well as any updates to those risk factors filed from time to time in the company's Quarterly Reports on Form 10-Q or Current Reports on Form 8-K.

------

**ITEM 9.01&nbsp;&nbsp;&nbsp;&nbsp;Financial Statements and Exhibits.**

---

| | |
|:---|:---|
| **Exhibit<br>Number** | **Description** |
| 99.1 | <u>[Earnings release dated](mygn-xq422earningsreleasex.htm)[February 28, 2023](mygn-xq422earningsreleasex.htm)[for the three months ended](mygn-xq422earningsreleasex.htm)[December 31](mygn-xq422earningsreleasex.htm)[, 2022.](mygn-xq422earningsreleasex.htm)</u> |
| 104 | Cover Page Interactive Data File (embedded within the Inline XBRL document). |

---

The exhibit(s) may contain hypertext links to information on our website or other parties' websites. The information on our website and other parties' websites is not incorporated by reference into this Current Report on Form 8-K and does not constitute a part of this Form 8-K.

In accordance with General Instruction B-2 of Form 8-K, the information set forth in Item 2.02 and in Exhibit 99.1 shall not be deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933, as amended or the Exchange Act, except as shall be expressly set forth by specific reference in such filing.

------

**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

---

| | | |
|:---|:---|:---|
| | **MYRIAD GENETICS, INC.** | **MYRIAD GENETICS, INC.** |
| Date: February 28, 2023 | By: | /s/ R. Bryan Riggsbee |
|  |  | R. Bryan Riggsbee |
|  |  | Chief Financial Officer |

---

## Exhibit 99.1

**Exhibit 99.1**

<u>News Release</u>

Media Contact: Megan Manzari Investor Contact: Matt Scalo

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(385) 318-3718 (801) 584-3532

megan.manzari@myriad.com matt.scalo@myriad.com

**Myriad Genetics Reports Fourth Quarter Financial Results; Fourth Quarter Revenue of $177.8 Million Grew 11% Year-Over-Year Driven by 16% Growth in Hereditary Cancer Volumes and 23% Growth in GeneSight**<sup>®</sup> **Volumes**

**Highlights:**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**• Fourth quarter testing volumes grew 26% year-over-year, and 11% year-over-year excluding the contribution from the recent acquisition of Gateway Genomics and its SneakPeek**<sup>®</sup> **Early Gender DNA Test.** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**• GeneSight, the company's pharmacogenomics test, grew revenue 36% for the full year 2022.**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**• Gross margin for the fourth quarter was approximately 70% reflecting underlying price stability and disciplined cost management.**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**• Diluted GAAP earnings per share (EPS) were $(0.52) and adjusted EPS were $(0.12) in the fourth quarter of 2022.**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**• Issued fiscal first quarter and full year 2023 financial guidance.**

**SALT LAKE CITY, February 28, 2023 –** Myriad Genetics, Inc. (NASDAQ: MYGN), a leader in genetic testing and precision medicine, today announced financial results for its fourth quarter ended December 31, 2022 and provided its outlook on business performance for 2023.

"Myriad Genetics ended 2022 with a strong fourth quarter. Our market-leading hereditary cancer test, MyRisk, achieved double-digit year-over-year growth in the quarter – a reflection of our team's hard work and the execution of our strategic growth plan," said Paul J. Diaz, president and CEO, Myriad Genetics. "We believe 2023 will be an exciting year as we continue to invest in our Labs of the Future strategy and enabling technologies to enhance our ability to better serve our patients and provider partners. We plan to introduce a number of new products in the second half of 2023, including Precise Liquid and FirstGene. And we are on-track to introduce Precise MRD to our pharma partners for research use." Mr. Diaz concluded, "We remain confident in our ability to achieve our goal of 10%+ annual growth by 2024 based on the progress we made in 2022 and the strong start to the year we are seeing through February. As we look to 2024 and beyond, we are excited about our robust product pipeline and a capital structure that enables Myriad Genetics to invest in future innovation and growth."

------

**Financial and Operational Highlights:**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Diagnostic test volumes of approximately 299,000 in the fourth quarter of 2022 increased 26% year-over-year. Hereditary cancer and pharmacogenomics volumes grew 16% and 23%, respectively, in the fourth quarter of 2022 compared to the fourth quarter of 2021.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• The following table summarizes year-over-year volume changes in the company's core product categories:

---

| | | |
|:---|:---|:---|
| | **Three months ended December 31,** | **Year ended December 31,** |
|  | **2022** | **2022** |
| &nbsp;&nbsp;&nbsp;Product volumes: |  |  |
| &nbsp;&nbsp;&nbsp;Hereditary cancer | 16% | 1% |
| &nbsp;&nbsp;&nbsp;Tumor profiling | —% | 1% |
| &nbsp;&nbsp;&nbsp;Prenatal | 40% | 9% |
| &nbsp;&nbsp;&nbsp;Pharmacogenomics | 23% | 35% |
| &nbsp;&nbsp;&nbsp;Total | 26% | 14% |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**•** Fourth quarter revenue of $177.8 million compared to the same period in 2021 was impacted by currency translations of $(3.6) million.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• The following table summarizes year-over-year revenue changes in the company's core businesses by product category:

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| | **Three months ended** | **Three months ended** | **Three months ended** | **Twelve months ended** | **Twelve months ended** | **Twelve months ended** |
| *(in millions)* | **December 31, 2022** | **December 31, 2021** | **% Change** | **December 31, 2022** | **December 31, 2021** | **% Change** |
| &nbsp;&nbsp;&nbsp;Product revenues: |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Hereditary cancer | $84.9 | $74.8 | 14% | $305.5 | $316.3 | (3)% |
| &nbsp;&nbsp;&nbsp;Tumor profiling | 31.7 | 26.5 | 20% | 128.6 | 120.9 | 6% |
| &nbsp;&nbsp;&nbsp;Prenatal | 29.1 | 30.1 | (3)% | 116.4 | 106.8 | 9% |
| &nbsp;&nbsp;&nbsp;Pharmacogenomics | 32.1 | 29.4 | 9% | 127.6 | 93.7 | 36% |
| &nbsp;&nbsp;&nbsp;Total | $177.8 | $160.8 | 11% | $678.1 | $637.7 | 6% |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• GAAP gross margins of 69.7% in the fourth quarter of 2022 decreased 180 basis points year-over-year, reflecting changes in product/volume mix as well as the impact of currency translation and inflationary pressures.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• GAAP total operating expenses in the fourth quarter of 2022 were $176.1 million, decreasing $18.0 million year-over-year. Adjusted operating expenses in the fourth quarter of 2022 increased $23.3 million year-over-year to $138.6 million, and reflects the incremental investments in research and development, technology and commercial tools, pipeline development and sales and marketing programs, and Gateway Genomics, as well as the impact of the inflationary environment.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• GAAP operating loss in the fourth quarter of 2022 was $52.2 million, increasing $9.1 million year-over-year; adjusted operating loss was $13.9 million, increasing $14.0 million year-over-year from adjusted operating income of $0.1 million in the fourth quarter of 2021.

------

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Ended the fourth quarter of 2022 with $169.7 million in cash, cash equivalents and marketable investment securities as compared to $257.2 million at the beginning of the quarter. The decrease was driven primarily by the acquisition of Gateway Genomics (closed November 1) and ongoing capital expenditures and investments in the company's laboratories of the future strategy.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Cash used in operating activities in the fourth quarter of 2022 was $7.7 million.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• The company ended the quarter with no debt outstanding.

**Business Performance and Highlights:**

**Oncology**

The Myriad Genetics Oncology business provides hereditary cancer testing, including the MyRisk hereditary cancer test for patients who have cancer. It also provides tumor profiling products such as the myChoice<sup>®</sup> CDx companion diagnostic test, the Prolaris<sup>®</sup> prostate cancer test, and the EndoPredict<sup>®</sup> breast cancer prognostic test. The Oncology business delivered revenue of $75.9 million in the fourth quarter of 2022.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Fourth quarter hereditary cancer testing volumes in Oncology grew 13% year-over-year. In addition, Prolaris continued to see strong demand as fourth quarter testing volumes grew 17% year-over-year.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Researcher enrollment in the first release of Myriad's Precise treatment registry has already reached approximately 100 individuals, spanning a broad mix of community and academic institutions. Clinicians have access to our cohort browser portal developed in partnership with DNANexus. The portal has already supported multiple collaborative research projects to advance cancer care.

**Women's Health**

The Myriad Genetics Women's Health business serves women of all ancestries by assessing their risk of cancer and offers prenatal testing solutions for those who are pregnant or planning a family. The Women's Health business delivered revenue of $69.8 million in the fourth quarter of 2022.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Fourth quarter hereditary cancer testing volumes in Women's Health grew 19% year-over-year and were higher than any prior quarter in 2022.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Fourth quarter results include a partial quarter contribution from the acquisition of Gateway Genomics, a personal genomics company and developer of consumer genetic tests including the No. 1 selling SneakPeek Early Gender DNA Test.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Excluding the contribution from Gateway Genomics, prenatal testing volumes in the fourth quarter of 2022 grew 2% sequentially versus the third quarter of 2022 and were down 1% versus the fourth quarter of 2021.

------

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• In February, 2023, the Journal of Genetic Counseling, the official journal of the National Society of Genetic Counselors (NSGC), published evidence-based guidelines for expanded carrier screening, which supports the potential increasing adoption and the growth of the company's carrier screening test, Foresight.

**Mental Health**

The Myriad Genetics Mental Health business consists of the GeneSight test that covers 64 medications commonly prescribed for depression, anxiety, attention deficit hyperactivity disorder, and other psychiatric conditions. GeneSight helps physicians understand how genetic alterations impact patient response to antidepressants and other drugs. In the pharmacogenomics category, the GeneSight test recorded revenue of $32.1 million in the fourth quarter of 2022.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• GeneSight, under Proprietary Laboratory Analyses (PLA) code 0345U, has been priced on the Medicare Clinical Lab Fee Schedule at $1,336 per test.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• In the fourth quarter, Myriad Genetics added over 3,000 clinicians who ordered GeneSight for the first time.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• The results of the Veterans Affairs research study (PRIME Care) using GeneSight to improve treatment for veterans with depression was identified as a top 10 genomic advancement for 2022 by the Genomic Medicine Working Group of the National Human Genome Research Institute's (NHGRI) Advisory council. The annual list of the most significant advances and accomplishments in genomic medicine was published by the *American Journal of Human Genetics*.

**Corporate Growth Initiatives Update:**

Myriad Genetics continues to execute its commercial and operational growth initiatives, including the enhancement of its core infrastructure to better communicate the company's differentiated value proposition, remove friction from engagement with healthcare providers and their patients, and gain reimbursement levels that reflect the value of Myriad's offering. With the ongoing support from partners, Bain Consulting and KPMG, Myriad has been able to speed decision making and increase productivity across the enterprise.

------

**Growth Strategy** 

In the fourth quarter of 2022, with the help of Bain Consulting, management conducted a strategic review of its current products and product pipeline, markets, competitive positioning and developed a roadmap for all of its products ("Product 360"). The purpose of this review was to gain a more rigorous and data driven "outside in" perspective of the company's competitiveness and ability to position each product to their full potential. This review sharpened its view on how to better address the needs of its provider partners and patients in Women's Health, Mental Health and Oncology. In addition, this review highlighted a focus on key patient sub-segments, such as the estimated 13 million women that meet the National Comprehensive Cancer Network (NCCN) guidelines for the company's market leading hereditary cancer test, MyRisk, as well as opportunities to better position and expand indications for Prolaris and MyChoice.

**Commercial** 

The company continues to implement digital tools and enabling technologies to improve patient, provider, and payer awareness, engagement, ease of use, and overall experience. Myriad Genetics has made significant progress on the following:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Enhanced corporate web presence to more fully digitize provider, patient and payor engagement.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Initiated limited launch of the unified ordering portal in early 2023 with roll out planned through 2023.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Launched first Epic EMR integration with a phased roll out through 2023 and beyond.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Continued to refine revenue cycle management (RCM) activities that have already seen significant improvement during 2021-2022 to further improve reimbursement of its products.

**Operations**

Myriad Genetics' laboratories of the future strategy enters 2023 with significant progress as we establish and move into modern and scalable facilities. This strategy supports the company's long-term goals to expand laboratory capacity, reduce cost and enhance testing automation. The company remains on-track to substantially complete both new facility construction and related developments and capital expenditure targets in 2023.

------

**Financial Guidance**

Below is a table summarizing Myriad Genetics' fiscal year 2023 financial guidance\*:

---

| | | | | |
|:---|:---|:---|:---|:---|
| **(in millions, except per share amounts)** | **FY 2023** | **FY 2023 Comments** | **Q1 2023** | **Q1 2023 Comments** |
| &nbsp;&nbsp;&nbsp;Revenue | $720 - $750 | Reflects annual growth of between 6% - 11% over 2022 | $170 - $172 | Expected to decrease ~3% from Q4 '22 reflecting seasonality |
| &nbsp;&nbsp;&nbsp;Gross margin % | 68% - 70% | GM expected to remain within range given seasonality | 68% | GM expected to decrease 200 basis points from Q4 '22 due to seasonality |
| &nbsp;&nbsp;&nbsp;GAAP OPEX | $628 - $648 |  | $165 - $167 |  |
| &nbsp;&nbsp;&nbsp;Adjusted OPEX | $530 - $550 | Adjusted operating expenses expected to remain flat-to-down from annualized Q4 '22 range | $138 - $140 | Adjusted operating expenses expected to remain flat in nominal dollars compared to Q4 '22 |
| &nbsp;&nbsp;&nbsp;GAAP EPS | $(1.43) - $(1.23) |  | $(0.47) - $(0.45) |  |
| &nbsp;&nbsp;&nbsp;Adjusted EPS | $(0.40) - $(0.20) | Adjusted EPS is expected to improve through 2023, reaching positive adjusted profitability and operating cash flow in Q4 '23 | $(0.20) - $(0.18) | Adjusted EPS loss expected to be greater than Q4 '22 due to ongoing investments combined with seasonality |

---

\* Assumes currency rates as of February 28, 2023

Myriad Genetics' fiscal year 2023 non-GAAP guidance begins with the comparable GAAP financial measure and excludes the estimated impact of stock-based compensation expense of approximately $40.0 million, non-cash amortization associated with acquisitions of approximately $43.0 million and special items such as costs related to transformation initiatives of approximately $15.0 million.

Myriad Genetics' fiscal first quarter of 2023 non-GAAP guidance begins with the comparable GAAP financial measure and excludes the estimated impact of stock-based compensation expense of approximately $10 million, non-cash amortization associated with acquisitions of approximately $11 million and special items such as costs related to transformation initiatives of approximately $6 million.

These projections are forward-looking statements and are subject to the risks summarized in the safe harbor statement at the end of this press release.

**Conference Call and Webcast**

A conference call will be held today, Tuesday, February 28, 2023, at 4:30 p.m. EST to discuss Myriad Genetics' financial results and business developments for the fourth quarter 2022. The dial-in number for domestic callers is 1-800-920-6941. International callers may dial 1-212-231-2939. All callers will be asked to reference reservation number 22025948. An archived replay of the call will be available for seven days by dialing 1-800-257-4607 and entering the reservation number above. The conference call and slide presentation will be available through a live webcast at www.myriad.com.

------

**About Myriad Genetics**

Myriad Genetics is a leading genetic testing and precision medicine company dedicated to advancing health and well-being for all. Myriad provides insights that help people take control of their health and enable healthcare providers to better detect, treat, and prevent disease. Myriad Genetics develops and offers genetic tests that help assess the risk of developing disease or disease progression and guide treatment decisions across medical specialties where critical genetic insights can significantly improve patient care and lower healthcare costs. For more information, visit <u>www.myriad.com</u>.

Myriad, the Myriad logo, BRACAnalysis, BRACAnalysis CDx, Colaris, ColarisAP, MyRisk, Myriad myRisk, MyRisk Hereditary Cancer, myChoice, Tumor BRACAnalysis CDx, MyChoice CDx, Prequel, Prequel with Amplify, Amplify, Foresight, Precise, FirstGene, SneakPeek, SneakPeek Early Gender DNA Test, Health.Illuminated., RiskScore, Prolaris, GeneSight, and EndoPredict are registered trademarks or trademarks of Myriad Genetics, Inc.. All third-party marks—<sup>®</sup> and <sup>™</sup>—are the property of their respective owners.© 2023 Myriad Genetics, Inc. All rights reserved.

------

**Revenue by Product (Unaudited):**

---

| | | | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | **Three months ended December 31,** | **Three months ended December 31,** | **Three months ended December 31,** | **Three months ended December 31,** | **Three months ended December 31,** | **Three months ended December 31,** | **Three months ended December 31,** | **Three months ended December 31,** | **Three months ended December 31,** | **Three months ended December 31,** | **Three months ended December 31,** |
| *(in millions)* | **2022** | **2022** | **2022** | **2022** | **2022** | **2021** | **2021** | **2021** | **2021** | **2021** | |
|  | **WH** | **ONC** | **MH** | **Other** | **Total** | **WH** | **ONC** | **MH** | **Other** | **Total** | **% Change** |
| Hereditary Cancer | $40.7 | $44.2 | $— | $— | $84.9 | $34.1 | $40.7 | $— | $— | $74.8 | 14% |
| Tumor Profiling |  | 31.7 |  |  | 31.7 |  | 26.5 |  |  | 26.5 | 20% |
| Prenatal | 29.1 |  |  |  | 29.1 | 30.1 |  |  |  | 30.1 | (3)% |
| Pharmacogenomics |  |  | 32.1 |  | 32.1 |  |  | 29.4 |  | 29.4 | 9% |
| Total Revenue | $69.8 | $75.9 | $32.1 | $— | $177.8 | $64.2 | $67.2 | $29.4 | $— | $160.8 | 11% |

---

---

| | | | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | **Year ended December 31,** | **Year ended December 31,** | **Year ended December 31,** | **Year ended December 31,** | **Year ended December 31,** | **Year ended December 31,** | **Year ended December 31,** | **Year ended December 31,** | **Year ended December 31,** | **Year ended December 31,** | **Year ended December 31,** |
| *(in millions)* | **2022** | **2022** | **2022** | **2022** | **2022** | **2021** | **2021** | **2021** | **2021** | **2021** | |
|  | **WH** | **ONC** | **MH** | **Other** | **Total** | **WH** | **ONC** | **MH** | **Other** | **Total** | **% Change** |
| Hereditary Cancer | $143.1 | $162.4 | $— | $— | $305.5 | $139.2 | $177.1 | $— | $— | $316.3 | (3)% |
| Tumor Profiling |  | 128.6 |  |  | 128.6 |  | 120.9 |  |  | 120.9 | 6% |
| Prenatal | 116.4 |  |  |  | 116.4 | 106.8 |  |  |  | 106.8 | 9% |
| Pharmacogenomics |  |  | 127.6 |  | 127.6 |  |  | 93.7 |  | 93.7 | 36% |
| Autoimmune |  |  |  | 0.3 | 0.3 |  |  |  | 28.2 | 28.2 | (99)% |
| Other |  |  |  |  |  |  |  |  | 0.5 | 0.5 | (99)% |
| Total testing revenue | 259.5 | 291.0 | 127.6 | 0.3 | 678.4 | 246.0 | 298.0 | 93.7 | 28.7 | 666.4 | 2% |
| Total other revenue |  |  |  |  |  |  |  |  | 24.2 | 24.2 | (100)% |
| Total Revenue | $259.5 | $291.0 | $127.6 | $0.3 | $678.4 | $246.0 | $298.0 | $93.7 | $52.9 | $690.6 | (2)% |

---

Business Units:

WH = Women's Health

ONC = Oncology

MH = Mental Health

Product Categories:

Hereditary Cancer – MyRisk, BRACAnalysis, BRACAnalysis CDx

Tumor Profiling – MyChoice CDx, Prolaris, EndoPredict

Prenatal – Foresight, Prequel, SneakPeek

Pharmacogenomics – GeneSight

Autoimmune – Vectra (sold in September 2021)

Other (testing) – myPath (sold in May 2021)

Other revenue – RBM (sold in July 2021), COVID-19 testing

------

**MYRIAD GENETICS, INC.**

**AND SUBSIDIARIES**

Consolidated Statements of Operations

(in millions, except per share amounts)

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three months ended<br>December 31,** | **Three months ended<br>December 31,** | **Year ended<br>December 31,** | **Year ended<br>December 31,** |
| | **2022** | **2021** | **2022** | **2021** |
| | (unaudited) | (unaudited) | | |
| Testing revenue | $177.8 | $160.8 | $678.4 | $666.4 |
| Other revenue |  |  |  | 24.2 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total revenue | 177.8 | 160.8 | 678.4 | 690.6 |
| &nbsp;&nbsp;&nbsp;&nbsp;Costs and expenses: |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Cost of testing revenue | 53.9 | 45.8 | 202.0 | 185.7 |
| &nbsp;&nbsp;&nbsp;&nbsp;Cost of other revenue |  |  |  | 11.9 |
| &nbsp;&nbsp;&nbsp;&nbsp;Research and development expense | 23.4 | 16.6 | 85.4 | 81.9 |
| &nbsp;&nbsp;&nbsp;&nbsp;Selling, general, and administrative expense | 146.5 | 127.5 | 514.7 | 537.8 |
| &nbsp;&nbsp;&nbsp;&nbsp;Legal charges pending settlement |  | 14.0 |  | 62.0 |
| &nbsp;&nbsp;&nbsp;&nbsp;Goodwill and long-lived asset impairment charges | 6.2 |  | 16.9 | 1.8 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total costs and expenses | 230.0 | 203.9 | 819.0 | 881.1 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Operating loss | (52.2) | (43.1) | (140.6) | (190.5) |
| Other income (expense): |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Interest income | 1.0 | 0.2 | 2.6 | 0.7 |
| &nbsp;&nbsp;&nbsp;&nbsp;Interest expense | (0.9) | (0.5) | (3.2) | (6.6) |
| &nbsp;&nbsp;&nbsp;&nbsp;Other |  | (0.1) | 0.6 | 139.3 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total other income (expense) | 0.1 | (0.4) |  | 133.4 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Loss before income tax | (52.1) | (43.5) | (140.6) | (57.1) |
| Income tax benefit | (9.8) | (35.9) | (28.6) | (29.9) |
| Net loss | $(42.3) | $(7.6) | $(112.0) | $(27.2) |
| Net loss attributable to non-controlling interest |  |  |  |  |
| Net loss attributable to Myriad Genetics, Inc. stockholders | $(42.3) | $(7.6) | $(112.0) | $(27.2) |
| Net loss per share: |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Basic and diluted | $(0.52) | $(0.10) | $(1.39) | $(0.35) |
| Weighted average shares outstanding: |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Basic and diluted | 81.5 | 79.9 | 80.6 | 78.0 |

---

------

**MYRIAD GENETICS, INC.**

**AND SUBSIDIARIES**

Consolidated Balance Sheets

(in millions, except share information)

---

| | | |
|:---|:---|:---|
| | **December 31, <br>2022** | **December 31,<br>2021** |
| **ASSETS** | | |
| Current assets: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Cash and cash equivalents | $56.9 | $257.4 |
| &nbsp;&nbsp;&nbsp;&nbsp;Marketable investment securities | 58.0 | 81.4 |
| &nbsp;&nbsp;&nbsp;&nbsp;Trade accounts receivable | 101.6 | 91.3 |
| &nbsp;&nbsp;&nbsp;&nbsp;Inventory | 20.1 | 15.3 |
| &nbsp;&nbsp;&nbsp;&nbsp;Prepaid taxes | 17.6 | 18.4 |
| &nbsp;&nbsp;&nbsp;&nbsp;Prepaid expenses and other current assets | 20.4 | 21.0 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total current assets | 274.6 | 484.8 |
| Operating lease right-of-use assets | 103.9 | 81.8 |
| Long-term marketable investment securities | 54.8 | 59.0 |
| Property, plant and equipment, net | 83.4 | 43.5 |
| Intangibles, net | 379.7 | 404.1 |
| Goodwill | 286.8 | 239.2 |
| Other assets | 15.5 | 8.3 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total assets | $1198.7 | $1320.7 |
| **LIABILITIES AND STOCKHOLDERS' EQUITY** |  |  |
| Current liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Accounts payable | 28.8 | 29.6 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accrued liabilities | 94.3 | 161.7 |
| &nbsp;&nbsp;&nbsp;&nbsp;Current maturities of operating lease liabilities | 14.1 | 13.0 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total current liabilities | 137.2 | 204.3 |
| Unrecognized tax benefits | 26.8 | 27.9 |
| Long-term deferred taxes | 3.5 | 35.8 |
| Noncurrent operating lease liabilities | 130.9 | 79.3 |
| Other long-term liabilities | 14.5 | 5.6 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total liabilities | 312.9 | 352.9 |
| Commitments and contingencies |  |  |
| Stockholders' equity: |  |  |
| Common stock, $0.01 par value, 81.2 and 80.0 shares outstanding at December 31, 2022 and 2021, respectively | 0.8 | 0.8 |
| &nbsp;&nbsp;&nbsp;&nbsp;Additional paid-in capital | 1260.1 | 1226.3 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accumulated other comprehensive loss | (8.9) | (5.1) |
| &nbsp;&nbsp;&nbsp;&nbsp;Accumulated deficit | (366.2) | (254.2) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total Myriad Genetics, Inc. stockholders' equity | 885.8 | 967.8 |
| &nbsp;&nbsp;&nbsp;&nbsp;Non-controlling interest |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total stockholders' equity | 885.8 | 967.8 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total liabilities and stockholders' equity | $1198.7 | $1320.7 |

---

------

**MYRIAD GENETICS, INC.**

**AND SUBSIDIARIES**

Consolidated Statements of Cash Flows

(in millions)

---

| | | |
|:---|:---|:---|
| | **Year Ended December 31,** | **Year Ended December 31,** |
| | **2022** | **2021** |
| **CASH FLOWS FROM OPERATING ACTIVITIES:** |  |  |
| Net loss attributable to Myriad Genetics, Inc. stockholders | $(112.0) | $(27.2) |
| &nbsp;&nbsp;&nbsp;&nbsp;Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Depreciation and amortization | 52.7 | 62.8 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Non-cash interest expense | 1.7 | 1.5 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Non-cash lease expense | 11.7 | 12.8 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Tenant improvement allowance received | 18.0 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Stock-based compensation expense | 38.1 | 36.3 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Deferred income taxes | (30.8) | (32.1) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Unrecognized tax benefits | (1.1) | (2.6) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Loss on inventory |  | 6.5 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Impairment of goodwill and long-lived assets | 16.9 | 1.8 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Gain on sale of assets |  | (162.0) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Changes in assets and liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Prepaid expenses and other current assets | 1.6 | (6.6) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Trade accounts receivable | (10.3) | (8.8) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Inventory | (2.9) | 1.6 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Prepaid taxes | 0.7 | 89.9 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Other assets | (0.9) | (3.6) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Accounts payable | (3.5) | 9.2 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Accrued liabilities | (81.2) | 65.7 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Deferred revenue | (5.0) | (26.6) |
| Net cash provided by (used in) operating activities | (106.3) | 18.6 |
| **CASH FLOWS FROM INVESTING ACTIVITIES:** |  |  |
| Capital expenditures | (45.3) | (18.0) |
| Acquisitions, net of cash acquired | (57.2) |  |
| Proceeds from sale of business and assets |  | 379.1 |
| Purchases of marketable investment securities | (103.2) | (147.8) |
| Proceeds from maturities and sales of marketable investment securities | 128.2 | 61.1 |
| Net cash provided by (used in) investing activities | (77.5) | 274.4 |
| **CASH FLOWS FROM FINANCING ACTIVITIES:** |  |  |
| Proceeds from common stock issued under stock-based compensation plans | 6.3 | 91.8 |
| Payment of tax withheld for common stock issued under stock-based compensation plans | (10.6) | (11.5) |
| Payment of contingent consideration recognized at acquisition | (3.0) | (3.3) |
| Fees associated with refinancing of revolving credit facility | (0.7) | (1.2) |
| Repayment of revolving credit facility |  | (226.4) |
| Net cash used in financing activities | (8.0) | (150.6) |
| Effect of foreign exchange rates on cash, cash equivalents, and restricted cash | (0.6) | (0.6) |
| Net increase (decrease) in cash, cash equivalents, and restricted cash | (192.4) | 141.8 |
| Cash, cash equivalents, and restricted cash at beginning of the period | 258.8 | 117.0 |
| Cash, cash equivalents, and restricted cash at end of the period | $66.4 | $258.8 |

---

------

**Safe Harbor Statement**

This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, including the company's fiscal year 2023 and first quarter 2023 financial guidance, and statements relating to the company's continuing investment in its laboratories of the future strategy and enabling technologies, the company's plans to introduce a number of new products in the second half of 2023, including Precise Liquid and FirstGene, the company's goal of achieving 10%+ annual revenue growth by 2024, the planned roll out of the unified ordering portal through 2023, the phased roll out of the Epic EMR integration through 2023 and beyond, and the company's expectation that both new facility construction and related developments and capital expenditure targets will be substantially completed in 2023. These "forward-looking statements" are management's present expectations of future events as of the date hereof and are subject to a number of known and unknown risks and uncertainties that could cause actual results, conditions, and events to differ materially and adversely from those anticipated. These risks include, but are not limited to: the risk that sales and profit margins of the company's existing tests may decline or that the company may not be able to operate its business on a profitable basis; risks related to the company's ability to achieve certain revenue growth targets and generate sufficient revenue from its existing product portfolio or in launching and commercializing new tests to be profitable; risks related to changes in governmental or private insurers' coverage and reimbursement levels for the company's tests or the company's ability to obtain reimbursement for its new tests at comparable levels to its existing tests; risks related to increased competition and the development of new competing tests; continued uncertainties associated with COVID-19, including its possible effects on the company's operations and the demand for its products; the risk that the company may be unable to develop or achieve commercial success for additional tests in a timely manner, or at all; the risk that the company may not successfully develop new markets or channels for its tests, including the company's ability to successfully generate substantial revenue outside the United States; the risk that licenses to the technology underlying the company's tests and any future tests are terminated or cannot be maintained on satisfactory terms; risks related to delays or other problems with constructing and operating the company's laboratory testing facilities; risks related to public concern over genetic testing in general or the company's tests in particular; risks related to regulatory requirements or enforcement in the United States and foreign countries and changes in the structure of the healthcare system or healthcare payment systems; risks related to the company's ability to obtain new corporate collaborations or licenses and acquire or develop new technologies or businesses on satisfactory terms, if at all; risks related to the company's ability to successfully integrate and derive benefits from any technologies or businesses that it licenses, acquires or develops; the risk that the company is not able to secure additional financing to fund its business, if needed, in a timely manner or on favorable terms, if it all; risks related to the company's projections about the potential market opportunity for the company's current and future products; the risk that the company or its licensors may be unable to protect or that third parties will infringe the proprietary technologies underlying the

------

company's tests; the risk of patent-infringement claims or challenges to the validity of the company's patents; risks related to changes in intellectual property laws covering the company's tests, or patents or enforcement, in the United States and foreign countries; risks related to security breaches, loss of data and other disruptions, including from cyberattacks; risks of new, changing and competitive technologies in the United States and internationally and that the company may not be able to keep pace with the rapid technology changes in its industry, or properly leverage new technologies to achieve or sustain competitive advantages in its products; the risk that the company may be unable to comply with financial operating covenants under the company's credit or lending agreements; risks related to the company's inability to achieve and maintain effective disclosure controls and procedures and internal control over financial reporting; risks related to current and future investigations, claims or lawsuits, including derivative claims, product or professional liability claims, and risks related to the amount of the company's insurance coverage limits and scope of insurance coverage with respect thereto; and other factors discussed under the heading "Risk Factors" contained in Item 1A of the company's Annual Report on Form 10-K filed with the U.S. Securities and Exchange Commission on February 25, 2022, as well as any updates to those risk factors filed from time to time in the company's Quarterly Reports on Form 10-Q or Current Reports on Form 8-K.

**Reconciliation of Revenue to Revenue Excluding Divested Businesses for the Three Months and Year ended December 31, 2022 and 2021**

*(unaudited data in millions)*

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three months ended** | **Three months ended** | **Year ended** | **Year ended** |
| | **December 31, 2022** | **December 31, 2021** | **December 31, 2022** | **December 31, 2021** |
| **Revenue Excluding Divested Businesses** | | | | |
| Revenue | $177.8 | $160.8 | $678.4 | $690.6 |
| &nbsp;&nbsp;Myriad RBM Revenues |  |  |  | (21.2) |
| &nbsp;&nbsp;Autoimmune Revenues |  |  | (0.3) | (28.3) |
| &nbsp;&nbsp;COVID Testing Revenues |  |  |  | (2.9) |
| &nbsp;&nbsp;MyPath Revenues |  |  |  | (0.5) |
| Revenue Excluding Divested Businesses | $177.8 | $160.8 | $678.1 | $637.7 |

---

------

**Statement regarding use of non-GAAP financial measures**

In this press release, the company's financial results and financial guidance are provided in accordance with accounting principles generally accepted in the United States (GAAP) and using certain non-GAAP financial measures. Management believes that presentation of operating results using non-GAAP financial measures provides useful supplemental information to investors and facilitates the analysis of the company's core operating results and comparison of operating results across reporting periods. Management also uses non-GAAP financial measures to establish budgets and to manage the company's business. A reconciliation of the GAAP financial results to non-GAAP financial results is included in the schedules below and a description of the adjustments made to the GAAP financial measures is included at the end of the schedules.

The company encourages investors to carefully consider its results under GAAP, as well as its supplemental non-GAAP information and the reconciliation between these presentations, to more fully understand its business. Non-GAAP financial results are reported in addition to, and not as a substitute for, or superior to, financial measures calculated in accordance with GAAP.

**Reconciliation of GAAP to Non-GAAP Financial Measures**

**for the Three Months and Year ended December 31, 2022 and 2021**

*(unaudited data in millions, except per share amounts)*

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three months ended <br>December 31,** | **Three months ended <br>December 31,** | **Year ended <br>December 31,** | **Year ended <br>December 31,** |
| | **2022** | **2021** | **2022** | **2021** |
| **Adjusted Gross Margin** |  |  |  |  |
| GAAP Gross Profit <sup>(1)</sup> | $123.9 | $115.0 | $476.4 | $493.0 |
| &nbsp;&nbsp;&nbsp;&nbsp;Equity compensation | 0.4 | 0.4 | 1.4 | 1.4 |
| &nbsp;&nbsp;&nbsp;Acquisition - amortization of intangible assets | 0.2 |  | 0.2 |  |
| &nbsp;&nbsp;Acquisition-related costs | 0.1 |  | 0.1 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Other adjustments |  |  |  | 1.3 |
| Adjusted Gross Profit | $124.6 | $115.4 | $478.1 | $495.7 |
| Adjusted Gross Margin | 70.1% | 71.8% | 70.5% | 71.8% |
| (1) Consists of total revenues less cost of testing revenue and cost of other revenue from the Consolidated Statements of Operations. | (1) Consists of total revenues less cost of testing revenue and cost of other revenue from the Consolidated Statements of Operations. | (1) Consists of total revenues less cost of testing revenue and cost of other revenue from the Consolidated Statements of Operations. | (1) Consists of total revenues less cost of testing revenue and cost of other revenue from the Consolidated Statements of Operations. | (1) Consists of total revenues less cost of testing revenue and cost of other revenue from the Consolidated Statements of Operations. |
|  | **Three months ended <br>December 31,** | **Three months ended <br>December 31,** | **Year ended <br>December 31,** | **Year ended <br>December 31,** |
|  | **2022** | **2021** | **2022** | **2021** |
| **Adjusted Operating Expenses** |  |  |  |  |
| GAAP Operating Expenses <sup>(1)</sup> | $176.1 | $158.1 | $617.0 | $683.5 |
| &nbsp;&nbsp;&nbsp;Acquisition - amortization of intangible assets | (10.3) | (9.8) | (40.7) | (50.1) |
| &nbsp;&nbsp;&nbsp;Goodwill and long-lived asset impairment charges | (6.1) |  | (16.8) | (1.8) |
| &nbsp;&nbsp;&nbsp;Equity compensation | (7.8) | (8.0) | (36.5) | (34.9) |
| &nbsp;&nbsp;&nbsp;Transformation initiatives | (5.6) | (6.0) | (17.8) | (24.8) |
| &nbsp;&nbsp;Divestiture-related costs |  |  |  | (1.8) |
| &nbsp;&nbsp;Acquisition-related costs | (4.8) |  | (5.0) |  |
| &nbsp;&nbsp;Legal charges, net of insurance reimbursement | (1.5) | (14.0) | 11.4 | (62.0) |
| &nbsp;&nbsp;&nbsp;Other adjustments | (1.4) | (5.0) | (0.7) | (21.4) |
| Adjusted Operating Expenses | $138.6 | $115.3 | $510.9 | $486.7 |
| (1) Consists of research and development expense, selling, general, and administrative expense, and goodwill and long-lived asset impairment charges from the Consolidated Statements of Operations. | (1) Consists of research and development expense, selling, general, and administrative expense, and goodwill and long-lived asset impairment charges from the Consolidated Statements of Operations. | (1) Consists of research and development expense, selling, general, and administrative expense, and goodwill and long-lived asset impairment charges from the Consolidated Statements of Operations. | (1) Consists of research and development expense, selling, general, and administrative expense, and goodwill and long-lived asset impairment charges from the Consolidated Statements of Operations. | (1) Consists of research and development expense, selling, general, and administrative expense, and goodwill and long-lived asset impairment charges from the Consolidated Statements of Operations. |

---

------

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three months ended <br>December 31,** | **Three months ended <br>December 31,** | **Year ended <br>December 31,** | **Year ended <br>December 31,** |
| | **2022** | **2021** | **2022** | **2021** |
| **Adjusted Operating Income (Loss)** |  |  |  |  |
| GAAP Operating Loss | $(52.2) | $(43.1) | $(140.6) | $(190.5) |
| &nbsp;&nbsp;&nbsp;Acquisition - amortization of intangible assets | 10.5 | 9.8 | 40.9 | 50.1 |
| &nbsp;&nbsp;&nbsp;Goodwill and long-lived asset impairment charges | 6.1 |  | 16.8 | 1.8 |
| &nbsp;&nbsp;&nbsp;Equity compensation | 8.2 | 8.4 | 37.8 | 36.3 |
| &nbsp;&nbsp;&nbsp;Transformation initiatives | 5.7 | 6.0 | 17.9 | 24.8 |
| &nbsp;&nbsp;Divestiture-related costs |  |  |  | 1.9 |
| &nbsp;&nbsp;Acquisition-related costs | 4.9 |  | 5.1 |  |
| &nbsp;&nbsp;Legal charges, net of insurance reimbursement | 1.5 | 14.0 | (11.4) | 62.0 |
| &nbsp;&nbsp;Other adjustments | 1.4 | 5.0 | 0.7 | 22.7 |
| Adjusted Operating Income (Loss) | $(13.9) | $0.1 | $(32.8) | $9.1 |
|  | **Three months ended <br>December 31,** | **Three months ended <br>December 31,** | **Year ended <br>December 31,** | **Year ended <br>December 31,** |
|  | **2022** | **2021** | **2022** | **2021** |
| **Adjusted Net Income (Loss)** <sup>(1)</sup> |  |  |  |  |
| GAAP Net Loss Attributable to Myriad Genetics, Inc. Stockholders | $(42.3) | $(7.6) | $(112.0) | $(27.2) |
| &nbsp;&nbsp;&nbsp;Acquisition - amortization of intangible assets | 10.5 | 9.8 | 40.9 | 50.1 |
| &nbsp;&nbsp;&nbsp;Goodwill and long-lived asset impairment charges | 6.1 |  | 16.8 | 1.8 |
| &nbsp;&nbsp;&nbsp;Equity compensation | 8.2 | 8.4 | 37.8 | 36.3 |
| &nbsp;&nbsp;&nbsp;Transformation initiatives | 5.7 | 6.0 | 17.9 | 24.8 |
| &nbsp;&nbsp;&nbsp;Gain on sale |  |  |  | (151.6) |
| &nbsp;&nbsp;&nbsp;Divestiture-related costs |  |  |  | 14.5 |
| &nbsp;&nbsp;Acquisition-related costs | 4.9 |  | 5.1 |  |
| &nbsp;&nbsp;&nbsp;Legal charges, net of insurance reimbursement | 1.5 | 14.0 | (11.4) | 62.0 |
| &nbsp;&nbsp;&nbsp;Other adjustments | 1.4 | 5.0 | 0.7 | 21.9 |
| &nbsp;&nbsp;&nbsp;Tax impact of non-GAAP adjustments | (5.7) | (37.2) | (20.0) | (31.2) |
| Adjusted Net Income (Loss) | $(9.7) | $(1.6) | $(24.2) | $1.4 |
| Weighted average shares outstanding: |  |  |  |  |
| &nbsp;&nbsp;Basic | 81.5 | 79.9 | 80.6 | 78.0 |
| &nbsp;&nbsp;Diluted | 81.5 | 79.9 | 80.6 | 80.2 |
| Adjusted Net Earnings Per Share |  |  |  |  |
| &nbsp;&nbsp;Basic | $(0.12) | $(0.02) | $(0.30) | $0.02 |
| &nbsp;&nbsp;Diluted | $(0.12) | $(0.02) | $(0.30) | $0.02 |
| (1) To determine Adjusted Net Earnings Per Share, or adjusted EPS. | (1) To determine Adjusted Net Earnings Per Share, or adjusted EPS. | (1) To determine Adjusted Net Earnings Per Share, or adjusted EPS. | (1) To determine Adjusted Net Earnings Per Share, or adjusted EPS. | (1) To determine Adjusted Net Earnings Per Share, or adjusted EPS. |

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------

**Adjusted Free Cash Flow Reconciliation**

**for the Three Months and Year Ended December 31, 2022 and 2021**

*(unaudited data in millions)*

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three months ended <br>December 31,** | **Three months ended <br>December 31,** | **Year ended <br>December 31,** | **Year ended <br>December 31,** |
| | **2022** | **2021** | **2022** | **2021** |
| **Cash flow from operations** | $(7.7) | $(9.5) | $(106.3) | $18.6 |
| &nbsp;&nbsp;Capital expenditures | (14.6) | (3.4) | (45.3) | (18.0) |
| Free cash flow | $(22.3) | $(12.9) | $(151.6) | $0.6 |
| &nbsp;&nbsp;Transformation initiatives | 5.7 | 6.0 | 17.9 | 24.4 |
| &nbsp;&nbsp;Legal charges, net of insurance reimbursement |  |  | 49.9 |  |
| &nbsp;&nbsp;Acquisition-related costs | 4.9 |  | 5.1 |  |
| &nbsp;&nbsp;Other adjustments |  | 5.0 |  | 10.2 |
| Adjusted free cash flow<sup>1</sup> | $(11.7) | $(1.9) | $(78.7) | $35.2 |
| (1) The Company revised its Adjusted Free Cash Flow metric in the quarter ended June 30, 2022 to exclude the tax impact, if any, associated with non-GAAP adjustments | (1) The Company revised its Adjusted Free Cash Flow metric in the quarter ended June 30, 2022 to exclude the tax impact, if any, associated with non-GAAP adjustments | (1) The Company revised its Adjusted Free Cash Flow metric in the quarter ended June 30, 2022 to exclude the tax impact, if any, associated with non-GAAP adjustments | (1) The Company revised its Adjusted Free Cash Flow metric in the quarter ended June 30, 2022 to exclude the tax impact, if any, associated with non-GAAP adjustments | (1) The Company revised its Adjusted Free Cash Flow metric in the quarter ended June 30, 2022 to exclude the tax impact, if any, associated with non-GAAP adjustments |

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Following is a description of the adjustments made to GAAP financial measures:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Acquisition – amortization of intangible assets – represents recurring amortization charges resulting from the acquisition of intangible assets.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Goodwill and long-lived asset impairment charges – impairment charges on long-lived assets and goodwill.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Equity compensation – non-cash equity-based compensation provided to Myriad Genetics employees and directors.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Transformation initiatives – transitory costs such as consulting and professional fees related to transformation initiatives and additional rent as a result of the build-out of our new laboratories in Salt Lake City, Utah and in South San Francisco, California, while maintaining our current laboratories in those locations.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Gain on sale — gain recognized in our divestitures of Myriad RBM, Inc. and the Myriad myPath, LLC laboratory.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Divestiture-related costs — non-recurring costs associated with our divestitures of the Myriad myPath, LLC laboratory, Myriad RBM, Inc., and the Myriad Autoimmune business.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Acquisition-related costs - non-recurring costs associated with our acquisition of Gateway Genomics, LLC.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Legal charges, net of insurance reimbursement – one-time legal expenses, net of insurance reimbursement. For the year ended December 31, 2021, we accrued $48.0 million for the settlement of the qui tam lawsuit and $14.0 million for settlement of the Abelli lawsuit.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Other adjustments – other one-time non-recurring expenses including changes in the fair value of contingent consideration related to acquisitions from prior years and severance costs for the three months and year ended December 31, 2022. For the three months and year ended December 31, 2021, the other one-time non-recurring expenses included expenses related to leadership transition, expenses related to non-recurring severance and retention agreements, non-recurring legal expenses and potential future consideration related to acquisitions from prior years.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Tax impact of non-GAAP adjustments – tax expense/(benefit) due to non-GAAP adjustments and differences between stock compensation recorded for book purposes as compared to the allowable tax deductions and, for the three months and year ended December 31, 2021, the CARES Act legislation.