# EDGAR Filing Document

**Accession Number:** 0000899148
**File Stem:** 0000940400-26-023170
**Filing Date:** 2026-6
**Character Count:** 31382
**Document Hash:** 317b36199ec21efb005fe911a90e8ae5
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000940400-26-023170.hdr.sgml**: 20260601

**ACCESSION NUMBER**: 0000940400-26-023170

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20260331

**FILED AS OF DATE**: 20260601

**DATE AS OF CHANGE**: 20260601

**PERIOD START**: 20260331

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** RYDEX SERIES FUNDS
- **CENTRAL INDEX KEY:** 0000899148

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **FISCAL YEAR END:** 0331

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-07584
- **FILM NUMBER:** 261049271

**BUSINESS ADDRESS:**
- **STREET 1:** 702 KING FARM BOULEVARD
- **STREET 2:** SUITE 200
- **CITY:** ROCKVILLE
- **STATE:** MD
- **ZIP:** 20850
- **BUSINESS PHONE:** 301-296-5100

**MAIL ADDRESS:**
- **STREET 1:** 702 KING FARM BOULEVARD
- **STREET 2:** SUITE 200
- **CITY:** ROCKVILLE
- **STATE:** MD
- **ZIP:** 20850

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** RYDEX DYNAMIC FUNDS
- **DATE OF NAME CHANGE:** 20170712

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** RYDEX SERIES FUNDS
- **DATE OF NAME CHANGE:** 20000229

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** RYDEX SERIES TRUST
- **DATE OF NAME CHANGE:** 19930714

## Series and Classes Contracts Data

### Biotechnology Fund (Series ID: S000003802)

| Class ID   | Class Name     | Ticker Symbol   |
|:---|:---|:---|
| C000010594 | Investor Class | RYOIX           |
| C000010595 | Class H        | RYOAX           |
| C000010596 | Class A        | RYBOX           |
| C000010597 | Class C        | RYCFX           |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** Rydex Series Funds

- **b. Investment Company Act file number:** 811-07584

- **c. CIK number of Registrant:** 0000899148

- **d. LEI of Registrant:** 5493004D62WV1EDNTU07

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 702 KING FARM BOULEVARD

  - **City:** ROCKVILLE

  - **State:** MD

  - **Foreign country:** US

  - **Zip / Postal Code:** 20850

  - **Telephone number:** 301-296-5100

**Item A.2. Information about the Series.**

- **a. Name of Series:** Biotechnology Fund

- **b. EDGAR series identifier (if any):** S000003802

- **c. LEI of Series:** 549300YENG103R306541

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2026-03-31

- **b. Date as of which information is reported:** 2026-03-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $135311610.18

**Total Liabilities:** $243887.09

**Net Assets:** $135067723.09

**Cash Not Reported:** $108.59

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000010595 | 2.09%                | 2.22%                | -2.29%               |
| Class ID C000010597 | 2.02%                | 2.16%                | -2.34%               |
| Class ID C000010596 | 2.09%                | 2.22%                | -2.28%               |
| Class ID C000010594 | 2.11%                | 2.24%                | -2.25%               |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $-87196.74               | $2686879.94                                |
| Month 2  | $54921.09                | $2969698.48                                |
| Month 3  | $2418091.16              | $-5474375.40                               |

### Schedule of Portfolio Investments

| Name                                               | Title                                                        | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Neurocrine Biosciences Inc                         | Neurocrine Biosciences Inc COM                               | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |     14527 | NS      | $1913786.98   | 1.42%             |  |  |  | No            |                  1 | On Loan: No      |
| Argenx SE                                          | Argenx SE SPONSORED ADR                                      | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |      2961 | NS      | $2162270.25   | 1.60%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC Therapeutics, Inc.                             | PTC Therapeutics, Inc. COM                                   | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |     18935 | NS      | $1290041.55   | 0.96%             |  |  |  | No            |                  1 | On Loan: No      |
| Axsome Therapeutics Inc.                           | Axsome Therapeutics Inc. COM                                 | CUSIP: 05464T104<br>LEI: 549300EXGR0XLRJEIB95 | Long             | EC               | CORP              | US        |      8171 | NS      | $1381062.42   | 1.02%             |  |  |  | No            |                  1 | On Loan: No      |
| LEGEND BIOTECH CORP                                | Legend Biotech Corporation SPONSORED ADS                     | CUSIP: 52490G102<br>LEI: 254900EIUFZTW136H859 | Long             | EC               | CORP              | KY        |     35054 | NS      | $634126.86    | 0.47%             |  |  |  | No            |                  1 | On Loan: No      |
| SANOFI SA - CVR                                    | SANOFI SA - CVR                                              | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8866 | NS      | $0.89         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| SUMMIT THERAPEUTICS INC                            | Summit Therapeutics Inc. COM                                 | CUSIP: 86627T108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     49213 | NS      | $933078.48    | 0.69%             |  |  |  | No            |                  1 | On Loan: No      |
| Sarepta Therapeutics Inc                           | Sarepta Therapeutics Inc COM                                 | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |     40226 | NS      | $875317.76    | 0.65%             |  |  |  | No            |                  1 | On Loan: No      |
| BioNTech SE                                        | BioNTech SE SPONSORED ADS                                    | CUSIP: 09075V102<br>LEI: 894500UZJ5LG1F8J1U58 | Long             | EC               | CORP              | DE        |     16159 | NS      | $1436211.92   | 1.06%             |  |  |  | No            |                  1 | On Loan: No      |
| CRISPR Therapeutics AG                             | CRISPR Therapeutics AG COM CHF0.03                           | CUSIP: 000000000<br>LEI: 506700O6IRRIQLT3W370 | Long             | EC               | CORP              | CH        |     32054 | NS      | $1524808.78   | 1.13%             |  |  |  | No            |                  1 | On Loan: No      |
| BEONE MEDICINES LTD                                | BeOne Medicines Ltd. SPONSORED ADS                           | CUSIP: 07725L102<br>LEI: 549300JFUK6FRD5MH739 | Long             | EC               | CORP              | CH        |     10395 | NS      | $3087003.15   | 2.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Krystal Biotech Inc                                | Krystal Biotech Inc COM                                      | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |      2474 | NS      | $639083.68    | 0.47%             |  |  |  | No            |                  1 | On Loan: —       |
| Revolution Medicines Inc                           | Revolution Medicines Inc COM                                 | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |     23475 | NS      | $2282943.75   | 1.69%             |  |  |  | No            |                  1 | On Loan: No      |
| Kymera Therapeutics Inc                            | Kymera Therapeutics Inc COM                                  | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     11658 | NS      | $970994.82    | 0.72%             |  |  |  | No            |                  1 | On Loan: No      |
| NATERA INC                                         | Natera Inc. COM                                              | CUSIP: 632307104<br>LEI: 529900CQ3OZ0A0VYVU59 | Long             | EC               | CORP              | US        |     14145 | NS      | $2828858.55   | 2.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Twist Bioscience Corporation                       | Twist Bioscience Corporation COM                             | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |     20054 | NS      | $952966.08    | 0.71%             |  |  |  | No            |                  1 | On Loan: No      |
| MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED | MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED TRI PARTY | CUSIP: 000000000<br>LEI: 8NAV47T0Y26Q87Y0QP81 | Long             | RA               | CORP              | US        |    282954 | PA      | $282954.15    | 0.21%             |  |  |  | No            |                  2 | On Loan: No      |
| Regeneron Pharmaceuticals, Inc.                    | Regeneron Pharmaceuticals, Inc. COM                          | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |      6224 | NS      | $4808911.36   | 3.56%             |  |  |  | No            |                  1 | On Loan: No      |
| Alkermes PLC                                       | Alkermes PLC COM USD0.01                                     | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | IE        |     56068 | NS      | $1982564.48   | 1.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Protagonist Therapeutics Inc                       | Protagonist Therapeutics Inc COM                             | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     11198 | NS      | $1180269.20   | 0.87%             |  |  |  | No            |                  1 | On Loan: No      |
| Vaxcyte Inc                                        | Vaxcyte Inc COM                                              | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |     26383 | NS      | $1533116.13   | 1.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Roivant Sciences Ltd                               | Roivant Sciences Ltd SHS                                     | CUSIP: 000000000<br>LEI: 549300DL466NY5J6U724 | Long             | EC               | CORP              | BM        |     68372 | NS      | $1893904.40   | 1.40%             |  |  |  | No            |                  1 | On Loan: No      |
| Biomarin Pharmaceutical Inc.                       | Biomarin Pharmaceutical Inc. COM                             | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |     29738 | NS      | $1679899.62   | 1.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Exelixis, Inc.                                     | Exelixis, Inc. COM                                           | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |     40607 | NS      | $1741634.23   | 1.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Royalty Pharma PLC                                 | Royalty Pharma PLC COM USD0.0001 CLASS A                     | CUSIP: 000000000<br>LEI: 549300FGFN7VOK8BZR03 | Long             | EC               | CORP              | GB        |     55739 | NS      | $2673799.83   | 1.98%             |  |  |  | No            |                  1 | On Loan: No      |
| Amgen Inc.                                         | Amgen Inc. COM                                               | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |     20093 | NS      | $7069722.05   | 5.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Ionis Pharmaceuticals, Inc.                        | Ionis Pharmaceuticals, Inc. COM                              | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |     24870 | NS      | $1867488.30   | 1.38%             |  |  |  | No            |                  1 | On Loan: No      |
| Bridgebio Pharma Inc                               | Bridgebio Pharma Inc COM                                     | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |     26764 | NS      | $1987494.64   | 1.47%             |  |  |  | No            |                  1 | On Loan: —       |
| Adma Biologics Inc                                 | Adma Biologics Inc COM                                       | CUSIP: 000899104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     65635 | NS      | $591371.35    | 0.44%             |  |  |  | No            |                  1 | On Loan: No      |
| AstraZeneca PLC                                    | AstraZeneca PLC ORD USD0.25                                  | CUSIP: 000000000<br>LEI: PY6ZZQWO2IZFZC3IOL08 | Long             | EC               | CORP              | GB        |     10974 | NS      | $2164292.28   | 1.60%             |  |  |  | No            |                  1 | On Loan: No      |
| APOGEE THERAPEUTICS INC                            | Apogee Therapeutics Inc. COM                                 | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     12066 | NS      | $1015595.22   | 0.75%             |  |  |  | No            |                  1 | On Loan: No      |
| Gilead Sciences Inc.                               | Gilead Sciences Inc. COM                                     | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |     48042 | NS      | $6695613.54   | 4.96%             |  |  |  | No            |                  1 | On Loan: No      |
| COGENT BIOSCIENCES INC                             | Cogent Biosciences Inc. COM                                  | CUSIP: 19240Q201<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     34752 | NS      | $1337604.48   | 0.99%             |  |  |  | No            |                  1 | On Loan: No      |
| Praxis Precision Medicines Inc                     | Praxis Precision Medicines Inc COM NEW                       | CUSIP: 74006W207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2092 | NS      | $674021.48    | 0.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Celcuity Inc.                                      | Celcuity Inc. COM                                            | CUSIP: 15102K100<br>LEI: 25490070W7UU7W2SEY87 | Long             | EC               | CORP              | US        |      7658 | NS      | $874084.12    | 0.65%             |  |  |  | No            |                  1 | On Loan: No      |
| J.P. MORGAN SECURITIES LLC                         | J.P. MORGAN SECURITIES LLC TRI PARTY                         | CUSIP: 000000000<br>LEI: ZBUT11V806EZRVTWT807 | Long             | RA               | CORP              | US        |    311357 | PA      | $311356.81    | 0.23%             |  |  |  | No            |                  2 | On Loan: No      |
| Madrigal Pharmaceuticals Inc                       | Madrigal Pharmaceuticals Inc COM                             | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |      2329 | NS      | $1219161.63   | 0.90%             |  |  |  | No            |                  1 | On Loan: No      |
| Travere Therapeutics Inc                           | Travere Therapeutics Inc COM                                 | CUSIP: 89422G107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     30251 | NS      | $898757.21    | 0.67%             |  |  |  | No            |                  1 | On Loan: No      |
| Amicus Therapeutics Inc.                           | Amicus Therapeutics Inc. COM                                 | CUSIP: 03152W109<br>LEI: 549300MRD1SMUTNBPQ53 | Long             | EC               | CORP              | US        |     76280 | NS      | $1103008.80   | 0.82%             |  |  |  | No            |                  1 | On Loan: No      |
| Insmed Inc                                         | Insmed Inc COM PAR $.01                                      | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |     20277 | NS      | $3315695.04   | 2.45%             |  |  |  | No            |                  1 | On Loan: No      |
| LIQUIDIA CORP                                      | Liquidia Corporation COM NEW                                 | CUSIP: 53635D202<br>LEI: 549300O826O5VQJTG707 | Long             | EC               | CORP              | US        |     22146 | NS      | $835790.04    | 0.62%             |  |  |  | No            |                  1 | On Loan: No      |
| Guardant Health Inc                                | Guardant Health Inc COM                                      | CUSIP: 40131M109<br>LEI: 254900M8C3E5VC8BR186 | Long             | EC               | CORP              | US        |     20606 | NS      | $1903376.22   | 1.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals Incorporated                | Vertex Pharmaceuticals Incorporated COM                      | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |     12119 | NS      | $5411618.26   | 4.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Incyte Corporation.                                | Incyte Corporation. COM                                      | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |     22317 | NS      | $2100476.04   | 1.56%             |  |  |  | No            |                  1 | On Loan: No      |
| Soleno Therapeutics Inc                            | Soleno Therapeutics Inc COM                                  | CUSIP: 834203309<br>LEI: 5493003LCY77N7FXK844 | Long             | EC               | CORP              | US        |     19659 | NS      | $658183.32    | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Rhythm Pharmaceuticals Inc                         | Rhythm Pharmaceuticals Inc COM                               | CUSIP: 76243J105<br>LEI: 529900JPNWXQ8DPLA551 | Long             | EC               | CORP              | US        |     12158 | NS      | $1057381.26   | 0.78%             |  |  |  | No            |                  1 | On Loan: No      |
| Viatris Inc                                        | Viatris Inc COM                                              | CUSIP: 92556V106<br>LEI: 254900ZZTSW7NL773X71 | Long             | EC               | CORP              | US        |    150073 | NS      | $2027486.23   | 1.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Mirum Pharmaceuticals Inc.                         | Mirum Pharmaceuticals Inc. COM                               | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |     13080 | NS      | $1208330.40   | 0.89%             |  |  |  | No            |                  1 | On Loan: No      |
| GRAIL Inc                                          | GRAIL Inc COM                                                | CUSIP: 384747101<br>LEI: 2549009XSNESW3VE8024 | Long             | EC               | CORP              | US        |     12830 | NS      | $663054.40    | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| ARCUTIS BIOTHERAPEUTICS INC                        | Arcutis Biotherapeutics Inc. COM                             | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     36923 | NS      | $869905.88    | 0.64%             |  |  |  | No            |                  1 | On Loan: No      |
| Moderna Inc                                        | Moderna Inc COM                                              | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |     43818 | NS      | $2225954.40   | 1.65%             |  |  |  | No            |                  1 | On Loan: No      |
| Halozyme Therapeutics Inc                          | Halozyme Therapeutics Inc COM                                | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |     22712 | NS      | $1467876.56   | 1.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Ultragenyx Pharmaceuticals Inc                     | Ultragenyx Pharmaceuticals Inc COM                           | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |     34041 | NS      | $713158.95    | 0.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals Inc.                       | Alnylam Pharmaceuticals Inc. COM                             | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |     10632 | NS      | $3517809.84   | 2.60%             |  |  |  | No            |                  1 | On Loan: No      |
| Acadia Pharmaceuticals Inc                         | Acadia Pharmaceuticals Inc COM                               | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |     40673 | NS      | $905380.98    | 0.67%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcellx Inc                                        | Arcellx Inc COMMON STOCK                                     | CUSIP: 03940C100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     11645 | NS      | $1337078.90   | 0.99%             |  |  |  | No            |                  1 | On Loan: No      |
| Akero Therapeutics Inc                             | Akero Therapeutics Inc                                       | CUSIP: 009CVR044<br>LEI: 549300SI3KG74LBE2955 | Long             | EC               | CORP              | US        |     17387 | NS      | $1.74         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Veracyte Inc                                       | Veracyte Inc COM                                             | CUSIP: 92337F107<br>LEI: 529900ESWZRHXOW27Z37 | Long             | EC               | CORP              | US        |     26685 | NS      | $859523.85    | 0.64%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvalent Inc                                       | Nuvalent Inc COM                                             | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      9053 | NS      | $927479.85    | 0.69%             |  |  |  | No            |                  1 | On Loan: No      |
| AbbVie Inc.                                        | AbbVie Inc. COM                                              | CUSIP: 00287Y109<br>LEI: FR5LCKFTG8054YNNRU85 | Long             | EC               | CORP              | US        |     45923 | NS      | $9987793.27   | 7.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Jazz Pharmaceuticals PLC                           | Jazz Pharmaceuticals PLC COM USD0.0001                       | CUSIP: 000000000<br>LEI: 635400GAUMJCLEZRRV50 | Long             | EC               | CORP              | IE        |     10448 | NS      | $1975194.40   | 1.46%             |  |  |  | No            |                  1 | On Loan: No      |
| Arrowhead Pharmaceuticals Inc                      | Arrowhead Pharmaceuticals Inc COM                            | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |     26370 | NS      | $1653399.00   | 1.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Recursion Pharmaceuticals Inc                      | Recursion Pharmaceuticals Inc CL A                           | CUSIP: 75629V104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    208931 | NS      | $641418.17    | 0.47%             |  |  |  | No            |                  1 | On Loan: No      |
| BEAM THERAPEUTICS INC                              | Beam Therapeutics Inc. COM                                   | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     31896 | NS      | $760081.68    | 0.56%             |  |  |  | No            |                  1 | On Loan: No      |
| United Therapeutics Corporation                    | United Therapeutics Corporation COM                          | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |      4711 | NS      | $2793528.78   | 2.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Apellis Pharmaceuticals Inc                        | Apellis Pharmaceuticals Inc COM                              | CUSIP: 03753U106<br>LEI: 254900HS0ZFRXXSB9D42 | Long             | EC               | CORP              | US        |     41107 | NS      | $1653734.61   | 1.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Illumina Inc                                       | Illumina Inc COM                                             | CUSIP: 452327109<br>LEI: SQ95QG8SR5Q56LSNF682 | Long             | EC               | CORP              | US        |     19053 | NS      | $2348472.78   | 1.74%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytokinetics Inc                                   | Cytokinetics Inc COM NEW                                     | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |     24093 | NS      | $1587969.63   | 1.18%             |  |  |  | No            |                  1 | On Loan: No      |
| TG Therapeutics Inc                                | TG Therapeutics Inc COM                                      | CUSIP: 88322Q108<br>LEI: 529900X21UKABN9NJ529 | Long             | EC               | CORP              | US        |     39225 | NS      | $1303054.50   | 0.96%             |  |  |  | No            |                  1 | On Loan: No      |
| Scholar Rock Holding Corp.                         | Scholar Rock Holding Corp. COM                               | CUSIP: 80706P103<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |     25883 | NS      | $1272408.28   | 0.94%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen Inc                                         | Biogen Inc COM                                               | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |     14803 | NS      | $2713833.99   | 2.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Intellia Therapeutics Inc                          | Intellia Therapeutics Inc COM                                | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |     49463 | NS      | $634115.66    | 0.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Viking Therapeutics Inc.                           | Viking Therapeutics Inc. COM                                 | CUSIP: 92686J106<br>LEI: 529900IVC72YPFA25M37 | Long             | EC               | CORP              | US        |     29278 | NS      | $952706.12    | 0.71%             |  |  |  | No            |                  1 | On Loan: —       |
| Ascendis Pharma A/S                                | Ascendis Pharma A/S SPONSORED ADR                            | CUSIP: 04351P101<br>LEI: 549300B66JN3W3J8GH73 | Long             | EC               | CORP              | DK        |      5974 | NS      | $1366433.02   | 1.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Medpace Holdings Inc.                              | Medpace Holdings Inc. COM                                    | CUSIP: 58506Q109<br>LEI: 549300H8TYEUVTW14A54 | Long             | EC               | CORP              | US        |      3540 | NS      | $1699872.60   | 1.26%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2026-06-01

**Name of Applicant:** Rydex Series Funds

**Signature:** James Howley

**Name of Signer:** James Howley

**Title:** Chief Financial Officer