# EDGAR Filing Document

**Accession Number:** 0001842296
**File Stem:** 0001842296-25-000003
**Filing Date:** 2025-8
**Character Count:** 48945
**Document Hash:** 0bafb48fd180d5f0b2622ce673f34fec
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001842296-25-000003.hdr.sgml**: 20250815

**ACCESSION NUMBER**: 0001842296-25-000003

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20250630

**FILED AS OF DATE**: 20250815

**DATE AS OF CHANGE**: 20250814

**EFFECTIVENESS DATE**: 20250815

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** E Fund Management Co., Ltd.
- **CENTRAL INDEX KEY:** 0001842296

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** F4
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-20539
- **FILM NUMBER:** 251222135

**BUSINESS ADDRESS:**
- **STREET 1:** 40-43/F, BANK OF GUANGZHOU SQUARE,
- **STREET 2:** NO.30 EAST ZHUJIANG ROAD,TIANHE DISTRICT
- **CITY:** GUANGZHOU
- **STATE:** F4
- **ZIP:** 510620
- **BUSINESS PHONE:** 8602-85102583

**MAIL ADDRESS:**
- **STREET 1:** 40-43/F, BANK OF GUANGZHOU SQUARE,
- **STREET 2:** NO.30 EAST ZHUJIANG ROAD,TIANHE DISTRICT
- **CITY:** GUANGZHOU
- **STATE:** F4
- **ZIP:** 510620

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 06-30-2025

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** E Fund Management Co. Ltd.<br>**Address:** 40-43/F BANK OF GUANGZHOU SQUARE<br>NO.30 EAST ZHUJIANG ROADTIANHE DISTRICT<br>GUANGZHOU, F4 510620

**Form 13F File Number:** 028-20539

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Wuwei Tang<br>**Title:** Compliance Manager<br>**Phone:** 8602085102583

**Signature, Place, and Date of Signing:**

Wuwei Tang  Guangzhou, F4  08-14-2025<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 394

**Form 13F Information Table Value Total:** $2097695043

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| Agilent Technologies Inc | Common Stock | 00846U101 | BBG000C2V3D6 | 350490 | 2970 | SH |  | SOLE |  | 2970 | 0 | 0 |
| Applied Optoelectronics Inc | Common Stock | 03823U102 | BBG000D6VW15 | 2938936 | 114400 | SH |  | SOLE |  | 114400 | 0 | 0 |
| Apple Inc | Common Stock | 037833100 | BBG000B9XRY4 | 110363405 | 537912 | SH |  | DFND |  | 537912 | 0 | 0 |
| AbbVie Inc | Common Stock | 00287Y109 | BBG0025Y4RY4 | 4713263 | 25392 | SH |  | SOLE |  | 25392 | 0 | 0 |
| Airbnb Inc | Common Stock | 009066101 | BBG001Y2XS07 | 1480620 | 11188 | SH |  | DFND |  | 11188 | 0 | 0 |
| Abbott Laboratories | Common Stock | 002824100 | BBG000B9ZXB4 | 2716528 | 19973 | SH |  | SOLE |  | 19973 | 0 | 0 |
| ACADIA Pharmaceuticals Inc | Common Stock | 004225108 | BBG000BHG9K0 | 302735 | 14035 | SH |  | SOLE |  | 14035 | 0 | 0 |
| Arcellx Inc | Common Stock | 03940C100 | BBG00QHJM4S9 | 414394 | 6293 | SH |  | SOLE |  | 6293 | 0 | 0 |
| Accenture PLC | Common Stock | G1151C101 | BBG000D9D830 | 4941548 | 16533 | SH |  | SOLE |  | 16533 | 0 | 0 |
| Adobe Inc | Common Stock | 00724F101 | BBG000BB5006 | 8216558 | 21238 | SH |  | DFND |  | 21238 | 0 | 0 |
| Analog Devices Inc | Common Stock | 032654105 | BBG000BB6G37 | 4964621 | 20858 | SH |  | DFND |  | 20858 | 0 | 0 |
| ADMA Biologics Inc | Common Stock | 000899104 | BBG002NCK5M5 | 540527 | 29683 | SH |  | SOLE |  | 29683 | 0 | 0 |
| Automatic Data Processing Inc | Common Stock | 053015103 | BBG000JG0547 | 3256087 | 10558 | SH |  | DFND |  | 10558 | 0 | 0 |
| Autodesk Inc | Common Stock | 052769106 | BBG000BM7HL0 | 2781486 | 8985 | SH |  | DFND |  | 8985 | 0 | 0 |
| American Electric Power Co Inc | Common Stock | 025537101 | BBG000BB9KF2 | 1436349 | 13843 | SH |  | DFND |  | 13843 | 0 | 0 |
| Arthur J Gallagher  Co | Common Stock | 363576109 | BBG000BBHXQ3 | 209358 | 654 | SH |  | SOLE |  | 654 | 0 | 0 |
| Akebia Therapeutics Inc | Common Stock | 00972D105 | BBG000R33R00 | 102914 | 28273 | SH |  | SOLE |  | 28273 | 0 | 0 |
| Akero Therapeutics Inc | Common Stock | 00973Y108 | BBG00L9211Y8 | 554677 | 10395 | SH |  | SOLE |  | 10395 | 0 | 0 |
| Align Technology Inc | Common Stock | 016255101 | BBG000BRNLL2 | 300656 | 1588 | SH |  | SOLE |  | 1588 | 0 | 0 |
| Alkermes PLC | Common Stock | G01767105 | BBG000C9F2F9 | 515066 | 18003 | SH |  | SOLE |  | 18003 | 0 | 0 |
| Alnylam Pharmaceuticals Inc | Common Stock | 02043Q107 | BBG000BFGNJ5 | 1171967 | 3594 | SH |  | SOLE |  | 3594 | 0 | 0 |
| Altimmune Inc | Common Stock | 02155H200 | BBG000FXML90 | 43952 | 11357 | SH |  | SOLE |  | 11357 | 0 | 0 |
| Applied Materials Inc | Common Stock | 038222105 | BBG000BBPFB9 | 6203144 | 33884 | SH |  | DFND |  | 33884 | 0 | 0 |
| Advanced Micro Devices Inc | Common Stock | 007903107 | BBG000BBQCY0 | 17846479 | 125768 | SH |  | DFND |  | 125768 | 0 | 0 |
| Amgen Inc | Common Stock | 031162100 | BBG000BBS2Y0 | 5184651 | 18569 | SH |  | DFND |  | 18569 | 0 | 0 |
| American Tower Corp | REIT | 03027X100 | BBG000B9XYV2 | 260141 | 1177 | SH |  | SOLE |  | 1177 | 0 | 0 |
| Amazon.com Inc | Common Stock | 023135106 | BBG000BVPV84 | 49111768 | 223856 | SH |  | DFND |  | 223856 | 0 | 0 |
| Arista Networks Inc | Common Stock | 040413205 | BBG000N2HDY5 | 1951870 | 19078 | SH |  | SOLE |  | 19078 | 0 | 0 |
| ANSYS Inc | Common Stock | 03662Q105 | BBG000GXZ4W7 | 1302675 | 3709 | SH |  | DFND |  | 3709 | 0 | 0 |
| Apogee Therapeutics Inc | Common Stock | 03770N101 | BBG01H51WYQ5 | 204121 | 4700 | SH |  | SOLE |  | 4700 | 0 | 0 |
| Amphenol Corp | Common Stock | 032095101 | BBG000B9YJ35 | 7416718 | 75106 | SH |  | SOLE |  | 75106 | 0 | 0 |
| Apellis Pharmaceuticals Inc | Common Stock | 03753U106 | BBG007KGRPY4 | 277947 | 16057 | SH |  | SOLE |  | 16057 | 0 | 0 |
| AppLovin Corp | Common Stock | 03831W108 | BBG006HFPX77 | 3629629 | 10368 | SH |  | DFND |  | 10368 | 0 | 0 |
| Ardelyx Inc | Common Stock | 039697107 | BBG001WH4DQ3 | 156890 | 40023 | SH |  | SOLE |  | 40023 | 0 | 0 |
| ARM Holdings PLC | ADR | 042068205 | BBG01J1GXZF0 | 2161978 | 13367 | SH |  | DFND |  | 13367 | 0 | 0 |
| Arcutis Biotherapeutics Inc | Common Stock | 03969K108 | BBG00QN8K4M4 | 240920 | 17184 | SH |  | SOLE |  | 17184 | 0 | 0 |
| Arrowhead Pharmaceuticals Inc | Common Stock | 04280A100 | BBG000BRVKH0 | 249656 | 15801 | SH |  | SOLE |  | 15801 | 0 | 0 |
| ASML Holding NV | NY Reg Shrs | N07059210 | BBG000K6MRN4 | 34490223 | 43038 | SH |  | DFND |  | 43038 | 0 | 0 |
| Autohome Inc | ADR | 05278C107 | BBG005JYTDQ5 | 8127744 | 315151 | SH |  | DFND |  | 315151 | 0 | 0 |
| Broadcom Inc | Common Stock | 11135F101 | BBG00KHY5S69 | 70917578 | 257274 | SH |  | DFND |  | 257274 | 0 | 0 |
| Anavex Life Sciences Corp | Common Stock | 032797300 | BBG000C9K8K4 | 94588 | 10259 | SH |  | SOLE |  | 10259 | 0 | 0 |
| Axon Enterprise Inc | Common Stock | 05464C101 | BBG000BHJWG1 | 1699761 | 2053 | SH |  | DFND |  | 2053 | 0 | 0 |
| American Express Co | Common Stock | 025816109 | BBG000BCQZS4 | 449762 | 1410 | SH |  | SOLE |  | 1410 | 0 | 0 |
| AstraZeneca PLC | ADR | 046353108 | BBG000BZ0DK8 | 970423 | 13887 | SH |  | DFND |  | 13887 | 0 | 0 |
| Boeing Co/The | Common Stock | 097023105 | BBG000BCSST7 | 403345 | 1925 | SH |  | SOLE |  | 1925 | 0 | 0 |
| Bank of America Corp | Common Stock | 060505104 | BBG000BCTLF6 | 3470733 | 73346 | SH |  | SOLE |  | 73346 | 0 | 0 |
| Baxter International Inc | Common Stock | 071813109 | BBG000BCVJ77 | 294412 | 9723 | SH |  | SOLE |  | 9723 | 0 | 0 |
| Bridgebio Pharma Inc | Common Stock | 10806X102 | BBG00P9KDZK6 | 948449 | 21965 | SH |  | SOLE |  | 21965 | 0 | 0 |
| BioCryst Pharmaceuticals Inc | Common Stock | 09058V103 | BBG000BLYWX6 | 300984 | 33592 | SH |  | SOLE |  | 33592 | 0 | 0 |
| Becton Dickinson  Co | Common Stock | 075887109 | BBG000BCZYD3 | 388252 | 2254 | SH |  | SOLE |  | 2254 | 0 | 0 |
| Beam Therapeutics Inc | Common Stock | 07373V105 | BBG00KXC8646 | 232612 | 13675 | SH |  | SOLE |  | 13675 | 0 | 0 |
| Biohaven Ltd | Common Stock | G1110E107 | BBG017BXV3Q9 | 190372 | 13492 | SH |  | SOLE |  | 13492 | 0 | 0 |
| Biogen Inc | Common Stock | 09062X103 | BBG000C17X76 | 1734398 | 13810 | SH |  | DFND |  | 13810 | 0 | 0 |
| Booking Holdings Inc | Common Stock | 09857L108 | BBG000BLBVN4 | 4897697 | 846 | SH |  | DFND |  | 846 | 0 | 0 |
| Baker Hughes Co | Common Stock | 05722G100 | BBG00GBVBK51 | 986373 | 25727 | SH |  | DFND |  | 25727 | 0 | 0 |
| Blackrock Inc | Common Stock | 09290D101 | BBG01PSW2WN4 | 392419 | 374 | SH |  | SOLE |  | 374 | 0 | 0 |
| BioMarin Pharmaceutical Inc | Common Stock | 09061G101 | BBG000CZWZ05 | 1031897 | 18772 | SH |  | SOLE |  | 18772 | 0 | 0 |
| Bristol-Myers Squibb Co | Common Stock | 110122108 | BBG000DQLV23 | 481833 | 10409 | SH |  | SOLE |  | 10409 | 0 | 0 |
| Blueprint Medicines Corp | Common Stock | 09627Y109 | BBG001MC8YF7 | 866625 | 6761 | SH |  | SOLE |  | 6761 | 0 | 0 |
| Berkshire Hathaway Inc | Common Stock | 084670702 | BBG000DWG505 | 7363787 | 15159 | SH |  | SOLE |  | 15159 | 0 | 0 |
| Boston Scientific Corp | Common Stock | 101137107 | BBG000C0LW92 | 691935 | 6442 | SH |  | SOLE |  | 6442 | 0 | 0 |
| Blackstone Inc | Common Stock | 09260D107 | BBG000BH0106 | 281061 | 1879 | SH |  | SOLE |  | 1879 | 0 | 0 |
| Kanzhun Ltd | ADR | 48553T106 | BBG01163M5L4 | 31792129 | 1782070 | SH |  | DFND |  | 1782070 | 0 | 0 |
| Citigroup Inc | Common Stock | 172967424 | BBG000FY4S11 | 399724 | 4696 | SH |  | SOLE |  | 4696 | 0 | 0 |
| Cardinal Health Inc | Common Stock | 14149Y108 | BBG000D898T9 | 390936 | 2327 | SH |  | SOLE |  | 2327 | 0 | 0 |
| Caterpillar Inc | Common Stock | 149123101 | BBG000BF0K17 | 459252 | 1183 | SH |  | SOLE |  | 1183 | 0 | 0 |
| Chubb Ltd | Common Stock | H1467J104 | BBG000BR14K5 | 279290 | 964 | SH |  | SOLE |  | 964 | 0 | 0 |
| Coca-Cola Europacific Partners | Common Stock | G25839104 | BBG00B6BFWH9 | 996833 | 10751 | SH |  | DFND |  | 10751 | 0 | 0 |
| Carnival Corp | Common Stock | 143658300 | BBG000BF6LY3 | 1445115 | 51391 | SH |  | SOLE |  | 51391 | 0 | 0 |
| Cadence Design Systems Inc | Common Stock | 127387108 | BBG000C13CD9 | 4402231 | 14286 | SH |  | DFND |  | 14286 | 0 | 0 |
| CDW Corp/DE | Common Stock | 12514G108 | BBG001P63B80 | 976352 | 5467 | SH |  | DFND |  | 5467 | 0 | 0 |
| Constellation Energy Corp | Common Stock | 21037T109 | BBG014KFRNP7 | 2621457 | 8122 | SH |  | DFND |  | 8122 | 0 | 0 |
| Celsius Holdings Inc | Common Stock | 15118V207 | BBG000NY37X4 | 1034729 | 22305 | SH |  | DFND |  | 22305 | 0 | 0 |
| CG oncology Inc | Common Stock | 156944100 | BBG00YHKK4Q3 | 232232 | 8932 | SH |  | SOLE |  | 8932 | 0 | 0 |
| Charter Communications Inc | Common Stock | 16119P108 | BBG000VPGNR2 | 1436559 | 3514 | SH |  | DFND |  | 3514 | 0 | 0 |
| Cigna Group/The | Common Stock | 125523100 | BBG00KXRCDP0 | 503804 | 1524 | SH |  | SOLE |  | 1524 | 0 | 0 |
| Celestica Inc | Common Stock | 15101Q207 | BBG000BPS2C3 | 11130643 | 71300 | SH |  | SOLE |  | 71300 | 0 | 0 |
| Cheetah Mobile Inc | ADR | 163075203 | BBG0068TQ8R9 | 333979 | 71363 | SH |  | SOLE |  | 71363 | 0 | 0 |
| Comcast Corp | Common Stock | 20030N101 | BBG000BFT2L4 | 3459324 | 96927 | SH |  | DFND |  | 96927 | 0 | 0 |
| CME Group Inc | Common Stock | 12572Q105 | BBG000BHLYP4 | 254948 | 925 | SH |  | SOLE |  | 925 | 0 | 0 |
| Centene Corp | Common Stock | 15135B101 | BBG000BDXCJ5 | 325626 | 5999 | SH |  | SOLE |  | 5999 | 0 | 0 |
| Capital One Financial Corp | Common Stock | 14040H105 | BBG000BGKTF9 | 349565 | 1643 | SH |  | SOLE |  | 1643 | 0 | 0 |
| Cogent Biosciences Inc | Common Stock | 19240Q201 | BBG007DHZQR7 | 73272 | 10205 | SH |  | SOLE |  | 10205 | 0 | 0 |
| Coherent Corp | Common Stock | 19247G107 | BBG000BLW102 | 624470 | 7000 | SH |  | SOLE |  | 7000 | 0 | 0 |
| Coinbase Global Inc | Common Stock | 19260Q107 | BBG00ZGF7771 | 1076355 | 3071 | SH |  | DFND |  | 3071 | 0 | 0 |
| Cooper Cos Inc/The | Common Stock | 216648501 | BBG000BG3445 | 297876 | 4186 | SH |  | SOLE |  | 4186 | 0 | 0 |
| ConocoPhillips | Common Stock | 20825C104 | BBG000BQQH30 | 290040 | 3232 | SH |  | SOLE |  | 3232 | 0 | 0 |
| Cencora Inc | Common Stock | 03073E105 | BBG000MDCQC2 | 408096 | 1361 | SH |  | SOLE |  | 1361 | 0 | 0 |
| Costco Wholesale Corp | Common Stock | 22160K105 | BBG000F6H8W8 | 14854050 | 15005 | SH |  | DFND |  | 15005 | 0 | 0 |
| Copart Inc | Common Stock | 217204106 | BBG000BM9RH1 | 1215267 | 24766 | SH |  | DFND |  | 24766 | 0 | 0 |
| Catalyst Pharmaceuticals Inc | Common Stock | 14888U101 | BBG000GZDC67 | 231235 | 10656 | SH |  | SOLE |  | 10656 | 0 | 0 |
| Credo Technology Group Holding | Common Stock | G25457105 | BBG00T68J2G0 | 294899 | 3185 | SH |  | SOLE |  | 3185 | 0 | 0 |
| Charles River Laboratories Int | Common Stock | 159864107 | BBG000BG5BL8 | 284342 | 1874 | SH |  | SOLE |  | 1874 | 0 | 0 |
| Salesforce Inc | Common Stock | 79466L302 | BBG000BN2DC2 | 6909965 | 25340 | SH |  | SOLE |  | 25340 | 0 | 0 |
| Crinetics Pharmaceuticals Inc | Common Stock | 22663K107 | BBG00BC59224 | 291368 | 10131 | SH |  | SOLE |  | 10131 | 0 | 0 |
| CRISPR Therapeutics AG | Common Stock | H17182108 | BBG00DBBGRX1 | 620841 | 12764 | SH |  | SOLE |  | 12764 | 0 | 0 |
| Crowdstrike Holdings Inc | Common Stock | 22788C105 | BBG00BLYKS03 | 5322290 | 10450 | SH |  | DFND |  | 10450 | 0 | 0 |
| Cisco Systems Inc | Common Stock | 17275R102 | BBG000C3J3C9 | 13731342 | 197915 | SH |  | DFND |  | 197915 | 0 | 0 |
| CoStar Group Inc | Common Stock | 22160N109 | BBG000D7JKW9 | 879897 | 10944 | SH |  | DFND |  | 10944 | 0 | 0 |
| CSX Corp | Common Stock | 126408103 | BBG000BGJRC8 | 1591006 | 48759 | SH |  | DFND |  | 48759 | 0 | 0 |
| Cintas Corp | Common Stock | 172908105 | BBG000H3YXF8 | 2307150 | 10352 | SH |  | DFND |  | 10352 | 0 | 0 |
| Cognizant Technology Solutions | Common Stock | 192446102 | BBG000BBDV81 | 1627940 | 20863 | SH |  | DFND |  | 20863 | 0 | 0 |
| CVS Health Corp | Common Stock | 126650100 | BBG000BGRY34 | 495621 | 7185 | SH |  | SOLE |  | 7185 | 0 | 0 |
| Chevron Corp | Common Stock | 166764100 | BBG000K4ND22 | 2461150 | 17188 | SH |  | SOLE |  | 17188 | 0 | 0 |
| China Yuchai International Ltd | Common Stock | G21082105 | BBG000BLSXG0 | 205937 | 8613 | SH |  | DFND |  | 8613 | 0 | 0 |
| Cytokinetics Inc | Common Stock | 23282W605 | BBG000F0R4N9 | 625084 | 18919 | SH |  | SOLE |  | 18919 | 0 | 0 |
| DoorDash Inc | Common Stock | 25809K105 | BBG005D7QCJ3 | 2665020 | 10811 | SH |  | DFND |  | 10811 | 0 | 0 |
| Day One Biopharmaceuticals Inc | Common Stock | 23954D109 | BBG00V1KSN04 | 71422 | 10988 | SH |  | SOLE |  | 10988 | 0 | 0 |
| Invesco DB Oil Fund | ETP | 46140H403 | BBG000QNH3T4 | 11044953 | 835473 | SH |  | SOLE |  | 835473 | 0 | 0 |
| Datadog Inc | Common Stock | 23804L103 | BBG003NJHZT9 | 2900722 | 21594 | SH |  | DFND |  | 21594 | 0 | 0 |
| Deere  Co | Common Stock | 244199105 | BBG000BH1NH9 | 330518 | 650 | SH |  | SOLE |  | 650 | 0 | 0 |
| Dell Technologies Inc | Common Stock | 24703L202 | BBG00DW3SZS1 | 681166 | 5556 | SH |  | SOLE |  | 5556 | 0 | 0 |
| Quest Diagnostics Inc | Common Stock | 74834L100 | BBG000BN84F3 | 314712 | 1752 | SH |  | SOLE |  | 1752 | 0 | 0 |
| Danaher Corp | Common Stock | 235851102 | BBG000BH3JF8 | 571483 | 2893 | SH |  | SOLE |  | 2893 | 0 | 0 |
| Walt Disney Co/The | Common Stock | 254687106 | BBG000BH4R78 | 2329280 | 18783 | SH |  | SOLE |  | 18783 | 0 | 0 |
| Denali Therapeutics Inc | Common Stock | 24823R105 | BBG008P7F869 | 190432 | 13612 | SH |  | SOLE |  | 13612 | 0 | 0 |
| Duke Energy Corp | Common Stock | 26441C204 | BBG000BHGDH5 | 230572 | 1954 | SH |  | SOLE |  | 1954 | 0 | 0 |
| DaVita Inc | Common Stock | 23918K108 | BBG000MQ1SN9 | 284188 | 1995 | SH |  | SOLE |  | 1995 | 0 | 0 |
| Dynavax Technologies Corp | Common Stock | 268158201 | BBG000BFX694 | 179681 | 18113 | SH |  | SOLE |  | 18113 | 0 | 0 |
| Dexcom Inc | Common Stock | 252131107 | BBG000QTF8K1 | 1156243 | 13246 | SH |  | DFND |  | 13246 | 0 | 0 |
| Dyne Therapeutics Inc | Common Stock | 26818M108 | BBG00NSGPJD0 | 116848 | 12274 | SH |  | SOLE |  | 12274 | 0 | 0 |
| Electronic Arts Inc | Common Stock | 285512109 | BBG000BP0KQ8 | 1026232 | 6426 | SH |  | DFND |  | 6426 | 0 | 0 |
| Elevance Health Inc | Common Stock | 036752103 | BBG000BCG930 | 486200 | 1250 | SH |  | SOLE |  | 1250 | 0 | 0 |
| Equinix Inc | REIT | 29444U700 | BBG000MBDGM6 | 202049 | 254 | SH |  | SOLE |  | 254 | 0 | 0 |
| Eaton Corp PLC | Common Stock | G29183103 | BBG000BJ3PD2 | 355562 | 996 | SH |  | SOLE |  | 996 | 0 | 0 |
| 89bio Inc | Common Stock | 282559103 | BBG00QKDZ8J5 | 133768 | 13622 | SH |  | SOLE |  | 13622 | 0 | 0 |
| Edwards Lifesciences Corp | Common Stock | 28176E108 | BBG000BRXP69 | 392614 | 5020 | SH |  | SOLE |  | 5020 | 0 | 0 |
| Exact Sciences Corp | Common Stock | 30063P105 | BBG000CWL0F5 | 1024433 | 19278 | SH |  | SOLE |  | 19278 | 0 | 0 |
| Exelon Corp | Common Stock | 30161N101 | BBG000J6XT05 | 1131786 | 26066 | SH |  | DFND |  | 26066 | 0 | 0 |
| Exelixis Inc | Common Stock | 30161Q104 | BBG000BQ4WF8 | 1141498 | 25899 | SH |  | SOLE |  | 25899 | 0 | 0 |
| Ford Motor Co | Common Stock | 345370860 | BBG000BQPC32 | 110757 | 10208 | SH |  | SOLE |  | 10208 | 0 | 0 |
| Diamondback Energy Inc | Common Stock | 25278X109 | BBG002PHSYX9 | 1003981 | 7307 | SH |  | DFND |  | 7307 | 0 | 0 |
| Fastenal Co | Common Stock | 311900104 | BBG000BJ8YN7 | 1255002 | 29881 | SH |  | DFND |  | 29881 | 0 | 0 |
| F5 Inc | Common Stock | 315616102 | BBG000CXYSZ6 | 329638 | 1120 | SH |  | SOLE |  | 1120 | 0 | 0 |
| Fiserv Inc | Common Stock | 337738108 | BBG000BJKPG0 | 247064 | 1433 | SH |  | SOLE |  | 1433 | 0 | 0 |
| Fair Isaac Corp | Common Stock | 303250104 | BBG000DW76Y6 | 822582 | 450 | SH |  | SOLE |  | 450 | 0 | 0 |
| Amicus Therapeutics Inc | Common Stock | 03152W109 | BBG000PLF6N0 | 265448 | 46326 | SH |  | SOLE |  | 46326 | 0 | 0 |
| First Solar Inc | Common Stock | 336433107 | BBG000BFL116 | 342502 | 2069 | SH |  | SOLE |  | 2069 | 0 | 0 |
| Fortinet Inc | Common Stock | 34959E109 | BBG000BCMBG4 | 3150562 | 29801 | SH |  | DFND |  | 29801 | 0 | 0 |
| Futu Holdings Ltd | ADR | 36118L106 | BBG00MYXW4R8 | 8765868 | 70927 | SH |  | DFND |  | 70927 | 0 | 0 |
| GoDaddy Inc | Common Stock | 380237107 | BBG006MDLY05 | 482021 | 2677 | SH |  | SOLE |  | 2677 | 0 | 0 |
| General Electric Co | Common Stock | 369604301 | BBG000BK6MB5 | 2996277 | 11641 | SH |  | DFND |  | 11641 | 0 | 0 |
| GE HealthCare Technologies Inc | Common Stock | 36266G107 | BBG01BFR8YV1 | 1140901 | 15403 | SH |  | DFND |  | 15403 | 0 | 0 |
| Gen Digital Inc | Common Stock | 668771108 | BBG000BH2JM1 | 305995 | 10408 | SH |  | SOLE |  | 10408 | 0 | 0 |
| Geron Corp | Common Stock | 374163103 | BBG000GX1891 | 130056 | 92238 | SH |  | SOLE |  | 92238 | 0 | 0 |
| GE Vernova Inc | Common Stock | 36828A101 | BBG013G17W31 | 367759 | 695 | SH |  | SOLE |  | 695 | 0 | 0 |
| GLOBALFOUNDRIES Inc | Common Stock | G39387108 | BBG000C2L5G9 | 489189 | 12806 | SH |  | DFND |  | 12806 | 0 | 0 |
| Gilead Sciences Inc | Common Stock | 375558103 | BBG000CKGBP2 | 4941143 | 44567 | SH |  | DFND |  | 44567 | 0 | 0 |
| SPDR Gold Shares | ETP | 78463V107 | BBG000CRF6Q8 | 23638347 | 77546 | SH |  | SOLE |  | 77546 | 0 | 0 |
| SPDR Gold MiniShares Trust | ETP | 98149E303 | BBG00L8YYP89 | 23647151 | 360915 | SH |  | SOLE |  | 360915 | 0 | 0 |
| Corning Inc | Common Stock | 219350105 | BBG000BKFZM4 | 752353 | 14306 | SH |  | SOLE |  | 14306 | 0 | 0 |
| Alphabet Inc | Common Stock | 02079K107 | BBG009S3NB30 | 18303810 | 103184 | SH |  | DFND |  | 103184 | 0 | 0 |
| Alphabet Inc | Common Stock | 02079K305 | BBG009S39JX6 | 23380435 | 132670 | SH |  | DFND |  | 132670 | 0 | 0 |
| GRAIL Inc | Common Stock | 384747101 | BBG01N6CGW43 | 234938 | 4569 | SH |  | SOLE |  | 4569 | 0 | 0 |
| Goldman Sachs Group Inc/The | Common Stock | 38141G104 | BBG000C6CFJ5 | 2278247 | 3219 | SH |  | SOLE |  | 3219 | 0 | 0 |
| Halozyme Therapeutics Inc | Common Stock | 40637H109 | BBG000CZ8W54 | 1036551 | 19926 | SH |  | SOLE |  | 19926 | 0 | 0 |
| HCA Healthcare Inc | Common Stock | 40412C101 | BBG000QW7VC1 | 448227 | 1170 | SH |  | SOLE |  | 1170 | 0 | 0 |
| Home Depot Inc/The | Common Stock | 437076102 | BBG000BKZB36 | 3785191 | 10324 | SH |  | SOLE |  | 10324 | 0 | 0 |
| Hilton Worldwide Holdings Inc | Common Stock | 43300A203 | BBG0058KMH30 | 2197571 | 8251 | SH |  | SOLE |  | 8251 | 0 | 0 |
| Hologic Inc | Common Stock | 436440101 | BBG000C3NTN5 | 302733 | 4646 | SH |  | SOLE |  | 4646 | 0 | 0 |
| Honeywell International Inc | Common Stock | 438516106 | BBG000H556T9 | 3886767 | 16690 | SH |  | DFND |  | 16690 | 0 | 0 |
| Robinhood Markets Inc | Common Stock | 770700102 | BBG008NMBXN8 | 280984 | 3001 | SH |  | DFND |  | 3001 | 0 | 0 |
| Hewlett Packard Enterprise Co | Common Stock | 42824C109 | BBG0078W3NQ3 | 507794 | 24831 | SH |  | SOLE |  | 24831 | 0 | 0 |
| HP Inc | Common Stock | 40434L105 | BBG000KHWT55 | 432233 | 17671 | SH |  | SOLE |  | 17671 | 0 | 0 |
| Henry Schein Inc | Common Stock | 806407102 | BBG000BNMMJ3 | 299140 | 4095 | SH |  | SOLE |  | 4095 | 0 | 0 |
| H World Group Ltd | ADR | 44332N106 | BBG000QFPM65 | 2822721 | 83217 | SH |  | DFND |  | 83217 | 0 | 0 |
| Humana Inc | Common Stock | 444859102 | BBG000BLKK03 | 352540 | 1442 | SH |  | SOLE |  | 1442 | 0 | 0 |
| Humacyte Inc | Common Stock | 44486Q103 | BBG00XPPT7S7 | 43106 | 20625 | SH |  | SOLE |  | 20625 | 0 | 0 |
| HUYA Inc | ADR | 44852D108 | BBG00KK4Q8G1 | 36604 | 10399 | SH |  | SOLE |  | 10399 | 0 | 0 |
| iShares Gold Trust | ETP | 464285204 | BBG000QLKDR4 | 23835738 | 382228 | SH |  | SOLE |  | 382228 | 0 | 0 |
| Interactive Brokers Group Inc | Common Stock | 45841N107 | BBG000LV0836 | 1108200 | 20000 | SH |  | SOLE |  | 20000 | 0 | 0 |
| International Business Machine | Common Stock | 459200101 | BBG000BLNNH6 | 7225647 | 24512 | SH |  | SOLE |  | 24512 | 0 | 0 |
| ImmunityBio Inc | Common Stock | 45256X103 | BBG007T9DYW9 | 74205 | 28108 | SH |  | SOLE |  | 28108 | 0 | 0 |
| Intercontinental Exchange Inc | Common Stock | 45866F104 | BBG000C1FB75 | 265481 | 1447 | SH |  | SOLE |  | 1447 | 0 | 0 |
| IDEXX Laboratories Inc | Common Stock | 45168D104 | BBG000BLRT07 | 1391266 | 2594 | SH |  | DFND |  | 2594 | 0 | 0 |
| Ideaya Biosciences Inc | Common Stock | 45166A102 | BBG00CTZ4D83 | 256969 | 12225 | SH |  | SOLE |  | 12225 | 0 | 0 |
| Immunovant Inc | Common Stock | 45258J102 | BBG00P5MC0Q8 | 189664 | 11854 | SH |  | SOLE |  | 11854 | 0 | 0 |
| Incyte Corp | Common Stock | 45337C102 | BBG000BNPSQ9 | 1356007 | 19912 | SH |  | SOLE |  | 19912 | 0 | 0 |
| Insmed Inc | Common Stock | 457669307 | BBG000BWM5P3 | 1102109 | 10951 | SH |  | SOLE |  | 10951 | 0 | 0 |
| Intel Corp | Common Stock | 458140100 | BBG000C0G1D1 | 4341255 | 193806 | SH |  | DFND |  | 193806 | 0 | 0 |
| Intuit Inc | Common Stock | 461202103 | BBG000BH5DV1 | 10963810 | 13920 | SH |  | DFND |  | 13920 | 0 | 0 |
| Ionis Pharmaceuticals Inc | Common Stock | 462222100 | BBG000JH6683 | 638482 | 16160 | SH |  | SOLE |  | 16160 | 0 | 0 |
| Iovance Biotherapeutics Inc | Common Stock | 462260100 | BBG000FTLBV7 | 56001 | 32559 | SH |  | SOLE |  | 32559 | 0 | 0 |
| iQIYI Inc | ADR | 46267X108 | BBG00K6DZBD3 | 3726080 | 2105130 | SH |  | SOLE |  | 2105130 | 0 | 0 |
| IQVIA Holdings Inc | Common Stock | 46266C105 | BBG00333FYS2 | 330781 | 2099 | SH |  | SOLE |  | 2099 | 0 | 0 |
| Intuitive Surgical Inc | Common Stock | 46120E602 | BBG000BJPDZ1 | 6862181 | 12628 | SH |  | DFND |  | 12628 | 0 | 0 |
| Gartner Inc | Common Stock | 366651107 | BBG000BB65D0 | 591374 | 1463 | SH |  | SOLE |  | 1463 | 0 | 0 |
| iShares Core S 500 ETF | ETP | 464287200 | BBG000BVZ4F5 | 19771940 | 31844 | SH |  | SOLE |  | 31844 | 0 | 0 |
| Jabil Inc | Common Stock | 466313103 | BBG000BJNGN9 | 427040 | 1958 | SH |  | SOLE |  | 1958 | 0 | 0 |
| Johnson Controls International | Common Stock | G51502105 | BBG000BVWLJ6 | 1037611 | 9824 | SH |  | DFND |  | 9824 | 0 | 0 |
| Johnson  Johnson | Common Stock | 478160104 | BBG000BMHYD1 | 4081785 | 26722 | SH |  | SOLE |  | 26722 | 0 | 0 |
| Juniper Networks Inc | Common Stock | 48203R104 | BBG000BY33P5 | 249682 | 6253 | SH |  | SOLE |  | 6253 | 0 | 0 |
| JOYY Inc | ADR | 46591M109 | BBG003H0XV18 | 6548349 | 128626 | SH |  | DFND |  | 128626 | 0 | 0 |
| JPMorgan Chase  Co | Common Stock | 46625H100 | BBG000DMBXR2 | 8407100 | 28999 | SH |  | SOLE |  | 28999 | 0 | 0 |
| Keurig Dr Pepper Inc | Common Stock | 49271V100 | BBG000TJM7F0 | 1160671 | 35108 | SH |  | DFND |  | 35108 | 0 | 0 |
| Keysight Technologies Inc | Common Stock | 49338L103 | BBG0059FN811 | 539263 | 3291 | SH |  | SOLE |  | 3291 | 0 | 0 |
| Kraft Heinz Co/The | Common Stock | 500754106 | BBG005CPNTQ2 | 767887 | 29740 | SH |  | DFND |  | 29740 | 0 | 0 |
| KKR  Co Inc | Common Stock | 48251W104 | BBG000BCQ6J8 | 234665 | 1764 | SH |  | SOLE |  | 1764 | 0 | 0 |
| KLA Corp | Common Stock | 482480100 | BBG000BMTFR4 | 29164399 | 32559 | SH |  | DFND |  | 32559 | 0 | 0 |
| Coca-Cola Co/The | Common Stock | 191216100 | BBG000BMX289 | 2971005 | 41993 | SH |  | SOLE |  | 41993 | 0 | 0 |
| Krystal Biotech Inc | Common Stock | 501147102 | BBG00HDGRHH7 | 531970 | 3870 | SH |  | SOLE |  | 3870 | 0 | 0 |
| Kura Oncology Inc | Common Stock | 50127T109 | BBG008974342 | 67521 | 11702 | SH |  | SOLE |  | 11702 | 0 | 0 |
| Legend Biotech Corp | ADR | 52490G102 | BBG00TTGH5W4 | 927425 | 26132 | SH |  | SOLE |  | 26132 | 0 | 0 |
| Labcorp Holdings Inc | Common Stock | 504922105 | BBG01MMT6PL7 | 323150 | 1231 | SH |  | SOLE |  | 1231 | 0 | 0 |
| Linde PLC | Common Stock | G54950103 | BBG01FND0CC1 | 7489051 | 15962 | SH |  | DFND |  | 15962 | 0 | 0 |
| Eli Lilly  Co | Common Stock | 532457108 | BBG000BNBDC2 | 6742155 | 8649 | SH |  | SOLE |  | 8649 | 0 | 0 |
| Lockheed Martin Corp | Common Stock | 539830109 | BBG000C1BW00 | 251022 | 542 | SH |  | SOLE |  | 542 | 0 | 0 |
| Lowe's Cos Inc | Common Stock | 548661107 | BBG000BNDN65 | 318162 | 1434 | SH |  | SOLE |  | 1434 | 0 | 0 |
| Lam Research Corp | Common Stock | 512807306 | BBG000BNFLM9 | 5226671 | 53695 | SH |  | DFND |  | 53695 | 0 | 0 |
| Lululemon Athletica Inc | Common Stock | 550021109 | BBG000R8ZVD1 | 704425 | 2965 | SH |  | DFND |  | 2965 | 0 | 0 |
| Las Vegas Sands Corp | Common Stock | 517834107 | BBG000JWD753 | 243438 | 5595 | SH |  | SOLE |  | 5595 | 0 | 0 |
| Mastercard Inc | Common Stock | 57636Q104 | BBG000F1ZSQ2 | 4755136 | 8462 | SH |  | SOLE |  | 8462 | 0 | 0 |
| Marriott International Inc/MD | Common Stock | 571903202 | BBG000BGD7W6 | 3873844 | 14179 | SH |  | DFND |  | 14179 | 0 | 0 |
| McDonald's Corp | Common Stock | 580135101 | BBG000BNSZP1 | 2171992 | 7434 | SH |  | SOLE |  | 7434 | 0 | 0 |
| Microchip Technology Inc | Common Stock | 595017104 | BBG000BHCP19 | 1591559 | 22617 | SH |  | DFND |  | 22617 | 0 | 0 |
| McKesson Corp | Common Stock | 58155Q103 | BBG000DYGNW7 | 503420 | 687 | SH |  | SOLE |  | 687 | 0 | 0 |
| Moody's Corp | Common Stock | 615369105 | BBG000F86GP6 | 936469 | 1867 | SH |  | SOLE |  | 1867 | 0 | 0 |
| Madrigal Pharmaceuticals Inc | Common Stock | 558868105 | BBG000QS6NV8 | 828931 | 2739 | SH |  | SOLE |  | 2739 | 0 | 0 |
| Mondelez International Inc | Common Stock | 609207105 | BBG000D4LWF6 | 2271042 | 33675 | SH |  | DFND |  | 33675 | 0 | 0 |
| Medtronic PLC | Common Stock | G5960L103 | BBG000BNWG87 | 545510 | 6258 | SH |  | SOLE |  | 6258 | 0 | 0 |
| MercadoLibre Inc | Common Stock | 58733R102 | BBG000GQPB11 | 3107606 | 1189 | SH |  | DFND |  | 1189 | 0 | 0 |
| Meta Platforms Inc | Common Stock | 30303M102 | BBG000MM2P62 | 37926017 | 51384 | SH |  | DFND |  | 51384 | 0 | 0 |
| Mirum Pharmaceuticals Inc | Common Stock | 604749101 | BBG00MH7T2M7 | 210837 | 4143 | SH |  | SOLE |  | 4143 | 0 | 0 |
| Marsh  McLennan Cos Inc | Common Stock | 571748102 | BBG000BP4MH0 | 272863 | 1248 | SH |  | SOLE |  | 1248 | 0 | 0 |
| 3M Co | Common Stock | 88579Y101 | BBG000BP52R2 | 208112 | 1367 | SH |  | SOLE |  | 1367 | 0 | 0 |
| MannKind Corp | Common Stock | 56400P706 | BBG000PPL3G9 | 97973 | 26196 | SH |  | SOLE |  | 26196 | 0 | 0 |
| Monster Beverage Corp | Common Stock | 61174X109 | BBG008NVB1C0 | 1532300 | 24462 | SH |  | DFND |  | 24462 | 0 | 0 |
| Altria Group Inc | Common Stock | 02209S103 | BBG000BP6LJ8 | 255040 | 4350 | SH |  | SOLE |  | 4350 | 0 | 0 |
| Molina Healthcare Inc | Common Stock | 60855R100 | BBG000MBHNC8 | 314582 | 1056 | SH |  | SOLE |  | 1056 | 0 | 0 |
| Hello Group Inc | ADR | 423403104 | BBG007HTCQT0 | 761516 | 90227 | SH |  | SOLE |  | 90227 | 0 | 0 |
| Monolithic Power Systems Inc | Common Stock | 609839105 | BBG000C30L48 | 674332 | 922 | SH |  | SOLE |  | 922 | 0 | 0 |
| Merck  Co Inc | Common Stock | 58933Y105 | BBG000BPD168 | 2328333 | 29413 | SH |  | SOLE |  | 29413 | 0 | 0 |
| Moderna Inc | Common Stock | 60770K107 | BBG003PHHZT1 | 1348185 | 48865 | SH |  | SOLE |  | 48865 | 0 | 0 |
| Marvell Technology Inc | Common Stock | 573874104 | BBG00ZXBJ153 | 1741268 | 22497 | SH |  | DFND |  | 22497 | 0 | 0 |
| Morgan Stanley | Common Stock | 617446448 | BBG000BLZRJ2 | 442723 | 3143 | SH |  | SOLE |  | 3143 | 0 | 0 |
| MSCI Inc | Common Stock | 55354G100 | BBG000RTDY25 | 209357 | 363 | SH |  | DFND |  | 363 | 0 | 0 |
| Microsoft Corp | Common Stock | 594918104 | BBG000BPH459 | 172388876 | 346573 | SH |  | DFND |  | 346573 | 0 | 0 |
| Motorola Solutions Inc | Common Stock | 620076307 | BBG000BP8Z50 | 1306369 | 3107 | SH |  | SOLE |  | 3107 | 0 | 0 |
| MicroStrategy Inc | Common Stock | 594972408 | BBG000GQJPZ0 | 2404764 | 5949 | SH |  | DFND |  | 5949 | 0 | 0 |
| Mettler-Toledo International I | Common Stock | 592688105 | BBG000BZCKH3 | 318349 | 271 | SH |  | SOLE |  | 271 | 0 | 0 |
| Micron Technology Inc | Common Stock | 595112103 | BBG000C5Z1S3 | 7927440 | 64320 | SH |  | DFND |  | 64320 | 0 | 0 |
| Myriad Genetics Inc | Common Stock | 62855J104 | BBG000D9H9F1 | 66773 | 12575 | SH |  | SOLE |  | 12575 | 0 | 0 |
| Neurocrine Biosciences Inc | Common Stock | 64125C109 | BBG000GJS7C1 | 1086213 | 8642 | SH |  | SOLE |  | 8642 | 0 | 0 |
| NextEra Energy Inc | Common Stock | 65339F101 | BBG000BJSBJ0 | 366329 | 5277 | SH |  | SOLE |  | 5277 | 0 | 0 |
| Cloudflare Inc | Common Stock | 18915M107 | BBG001WMKHH5 | 2270453 | 11594 | SH |  | SOLE |  | 11594 | 0 | 0 |
| Netflix Inc | Common Stock | 64110L106 | BBG000CL9VN6 | 23904809 | 17851 | SH |  | DFND |  | 17851 | 0 | 0 |
| Niu Technologies | ADR | 65481N100 | BBG00M37BS44 | 53760 | 16000 | SH |  | SOLE |  | 16000 | 0 | 0 |
| NIKE Inc | Common Stock | 654106103 | BBG000C5HS04 | 217453 | 3061 | SH |  | SOLE |  | 3061 | 0 | 0 |
| ServiceNow Inc | Common Stock | 81762P102 | BBG000M1R011 | 11406548 | 11095 | SH |  | DFND |  | 11095 | 0 | 0 |
| NetApp Inc | Common Stock | 64110D104 | BBG000FP1N32 | 389227 | 3653 | SH |  | SOLE |  | 3653 | 0 | 0 |
| Intellia Therapeutics Inc | Common Stock | 45826J105 | BBG007KC7PB0 | 134500 | 14339 | SH |  | SOLE |  | 14339 | 0 | 0 |
| Natera Inc | Common Stock | 632307104 | BBG001J1BQ86 | 1087129 | 6435 | SH |  | SOLE |  | 6435 | 0 | 0 |
| Nuvalent Inc | Common Stock | 670703107 | BBG00Z1SLMK5 | 412096 | 5401 | SH |  | SOLE |  | 5401 | 0 | 0 |
| Novavax Inc | Common Stock | 670002401 | BBG000NVSBL7 | 178164 | 28280 | SH |  | SOLE |  | 28280 | 0 | 0 |
| NVIDIA Corp | Common Stock | 67066G104 | BBG000BBJQV0 | 150809828 | 954553 | SH |  | DFND |  | 954553 | 0 | 0 |
| NXP Semiconductors NV | Common Stock | N6596X109 | BBG000BND699 | 2315557 | 10598 | SH |  | DFND |  | 10598 | 0 | 0 |
| Old Dominion Freight Line Inc | Common Stock | 679580100 | BBG000CHSS88 | 875933 | 5397 | SH |  | DFND |  | 5397 | 0 | 0 |
| ON Semiconductor Corp | Common Stock | 682189105 | BBG000DV7MX4 | 1615958 | 30833 | SH |  | DFND |  | 30833 | 0 | 0 |
| Oracle Corp | Common Stock | 68389X105 | BBG000BQLTW7 | 13945096 | 63784 | SH |  | DFND |  | 63784 | 0 | 0 |
| O'Reilly Automotive Inc | Common Stock | 67103H107 | BBG000BGYWY6 | 2004852 | 22244 | SH |  | DFND |  | 22244 | 0 | 0 |
| Palo Alto Networks Inc | Common Stock | 697435105 | BBG0014GJCT9 | 5715186 | 27928 | SH |  | DFND |  | 27928 | 0 | 0 |
| Paychex Inc | Common Stock | 704326107 | BBG000BQSQ38 | 1345214 | 9248 | SH |  | DFND |  | 9248 | 0 | 0 |
| PACCAR Inc | Common Stock | 693718108 | BBG000BQVTF5 | 1298805 | 13663 | SH |  | DFND |  | 13663 | 0 | 0 |
| Vaxcyte Inc | Common Stock | 92243G108 | BBG009PHHPL8 | 598119 | 18398 | SH |  | SOLE |  | 18398 | 0 | 0 |
| PDD Holdings Inc | ADR | 722304102 | BBG00LBLDDR2 | 356233439 | 3403721 | SH |  | DFND |  | 3403721 | 0 | 0 |
| PepsiCo Inc | Common Stock | 713448108 | BBG000DH7JK6 | 6126524 | 46399 | SH |  | DFND |  | 46399 | 0 | 0 |
| Pfizer Inc | Common Stock | 717081103 | BBG000BR2B91 | 614169 | 25337 | SH |  | SOLE |  | 25337 | 0 | 0 |
| Procter  Gamble Co/The | Common Stock | 742718109 | BBG000BR2TH3 | 3881672 | 24364 | SH |  | SOLE |  | 24364 | 0 | 0 |
| Progressive Corp/The | Common Stock | 743315103 | BBG000BR37X2 | 401357 | 1504 | SH |  | SOLE |  | 1504 | 0 | 0 |
| Parker-Hannifin Corp | Common Stock | 701094104 | BBG000BR3KL6 | 224907 | 322 | SH |  | SOLE |  | 322 | 0 | 0 |
| Prologis Inc | REIT | 74340W103 | BBG000B9Z0J8 | 250080 | 2379 | SH |  | SOLE |  | 2379 | 0 | 0 |
| Palantir Technologies Inc | Common Stock | 69608A108 | BBG000N7QR55 | 16824341 | 123418 | SH |  | DFND |  | 123418 | 0 | 0 |
| Philip Morris International In | Common Stock | 718172109 | BBG000J2XL74 | 2949049 | 16192 | SH |  | SOLE |  | 16192 | 0 | 0 |
| Insulet Corp | Common Stock | 45784P101 | BBG000R7XX87 | 324548 | 1033 | SH |  | SOLE |  | 1033 | 0 | 0 |
| PTC Inc | Common Stock | 69370C100 | BBG000C2VBB0 | 394142 | 2287 | SH |  | SOLE |  | 2287 | 0 | 0 |
| PTC Therapeutics Inc | Common Stock | 69366J200 | BBG000QT15P7 | 532258 | 10898 | SH |  | SOLE |  | 10898 | 0 | 0 |
| Protagonist Therapeutics Inc | Common Stock | 74366E102 | BBG002B63KM7 | 496877 | 8990 | SH |  | SOLE |  | 8990 | 0 | 0 |
| PayPal Holdings Inc | Common Stock | 70450Y103 | BBG0077VNXV6 | 1867067 | 25122 | SH |  | DFND |  | 25122 | 0 | 0 |
| QUALCOMM Inc | Common Stock | 747525103 | BBG000CGC1X8 | 8730474 | 54819 | SH |  | DFND |  | 54819 | 0 | 0 |
| Qifu Technology Inc | ADR | 88557W101 | BBG00MDY4KL0 | 23098262 | 532709 | SH |  | DFND |  | 532709 | 0 | 0 |
| Ultragenyx Pharmaceutical Inc | Common Stock | 90400D108 | BBG001RWPDW6 | 329131 | 9052 | SH |  | SOLE |  | 9052 | 0 | 0 |
| ROBLOX Corp | Common Stock | 771049103 | BBG001R1GCT0 | 1545914 | 14695 | SH |  | DFND |  | 14695 | 0 | 0 |
| Rubrik Inc | Common Stock | 781154109 | BBG008D32605 | 1139585 | 12720 | SH |  | DFND |  | 12720 | 0 | 0 |
| Royal Caribbean Cruises Ltd | Common Stock | V7780T103 | BBG000BB5792 | 3370326 | 10763 | SH |  | DFND |  | 10763 | 0 | 0 |
| Arcus Biosciences Inc | Common Stock | 03969F109 | BBG00DQD26W3 | 89434 | 10987 | SH |  | SOLE |  | 10987 | 0 | 0 |
| Reddit Inc | Common Stock | 75734B100 | BBG005K1D4S0 | 452613 | 3006 | SH |  | DFND |  | 3006 | 0 | 0 |
| Regeneron Pharmaceuticals Inc | Common Stock | 75886F107 | BBG000C734W3 | 2797725 | 5329 | SH |  | DFND |  | 5329 | 0 | 0 |
| ATRenew Inc | ADR | 00138L108 | BBG0118LLJB4 | 405607 | 122540 | SH |  | SOLE |  | 122540 | 0 | 0 |
| Ralph Lauren Corp | Common Stock | 751212101 | BBG000BS0ZF1 | 587782 | 2143 | SH |  | SOLE |  | 2143 | 0 | 0 |
| Relay Therapeutics Inc | Common Stock | 75943R102 | BBG00DSS08K9 | 70093 | 20258 | SH |  | SOLE |  | 20258 | 0 | 0 |
| ResMed Inc | Common Stock | 761152107 | BBG000L4M7F1 | 369456 | 1432 | SH |  | SOLE |  | 1432 | 0 | 0 |
| Avidity Biosciences Inc | Common Stock | 05370A108 | BBG00FQ7LXW1 | 402229 | 14163 | SH |  | SOLE |  | 14163 | 0 | 0 |
| Roivant Sciences Ltd | Common Stock | G76279101 | BBG007STW2B8 | 743302 | 65954 | SH |  | SOLE |  | 65954 | 0 | 0 |
| Roper Technologies Inc | Common Stock | 776696106 | BBG000F1ZSN5 | 2558149 | 4513 | SH |  | DFND |  | 4513 | 0 | 0 |
| Ross Stores Inc | Common Stock | 778296103 | BBG000BSBZH7 | 1082517 | 8485 | SH |  | DFND |  | 8485 | 0 | 0 |
| RTX Corp | Common Stock | 75513E101 | BBG000BW8S60 | 489897 | 3355 | SH |  | SOLE |  | 3355 | 0 | 0 |
| Revolution Medicines Inc | Common Stock | 76155X100 | BBG00829F4P8 | 628189 | 17075 | SH |  | SOLE |  | 17075 | 0 | 0 |
| Revvity Inc | Common Stock | 714046109 | BBG000FXW512 | 300219 | 3104 | SH |  | SOLE |  | 3104 | 0 | 0 |
| Recursion Pharmaceuticals Inc | Common Stock | 75629V104 | BBG00PQ4XJ45 | 200644 | 39653 | SH |  | SOLE |  | 39653 | 0 | 0 |
| Rhythm Pharmaceuticals Inc | Common Stock | 76243J105 | BBG007DLZ601 | 364038 | 5761 | SH |  | SOLE |  | 5761 | 0 | 0 |
| SAP SE | ADR | 803054204 | BBG000BDSLD7 | 1595005 | 5245 | SH |  | DFND |  | 5245 | 0 | 0 |
| Starbucks Corp | Common Stock | 855244109 | BBG000CTQBF3 | 2711423 | 29591 | SH |  | DFND |  | 29591 | 0 | 0 |
| Charles Schwab Corp/The | Common Stock | 808513105 | BBG000BSLZY7 | 394887 | 4328 | SH |  | SOLE |  | 4328 | 0 | 0 |
| Sea Ltd | ADR | 81141R100 | BBG00HTBWMG5 | 1634587 | 10220 | SH |  | DFND |  | 10220 | 0 | 0 |
| ETFS GOLD TR | PHYSCL GOLD SHS | 00326A104 | BBG000BDHB87 | 23758798 | 753291 | SH |  | SOLE |  | 753291 | 0 | 0 |
| Shopify Inc | Common Stock | 82509L107 | BBG008HBD923 | 3228877 | 27992 | SH |  | SOLE |  | 27992 | 0 | 0 |
| Sherwin-Williams Co/The | Common Stock | 824348106 | BBG000BSXQV7 | 204299 | 595 | SH |  | SOLE |  | 595 | 0 | 0 |
| Soleno Therapeutics Inc | Common Stock | 834203309 | BBG0024L5B86 | 443280 | 5291 | SH |  | SOLE |  | 5291 | 0 | 0 |
| Super Micro Computer Inc | Common Stock | 86800U302 | BBG000MYZDJ3 | 446432 | 9109 | SH |  | SOLE |  | 9109 | 0 | 0 |
| Summit Therapeutics Inc | Common Stock | 86627T108 | BBG00X3GQL76 | 472331 | 22196 | SH |  | SOLE |  | 22196 | 0 | 0 |
| Syndax Pharmaceuticals Inc | Common Stock | 87164F105 | BBG000R33JY1 | 131419 | 14033 | SH |  | SOLE |  | 14033 | 0 | 0 |
| Synopsys Inc | Common Stock | 871607107 | BBG000BSFRF3 | 3329857 | 6495 | SH |  | DFND |  | 6495 | 0 | 0 |
| Southern Co/The | Common Stock | 842587107 | BBG000BT9DW0 | 258226 | 2812 | SH |  | SOLE |  | 2812 | 0 | 0 |
| Sohu.com Ltd | ADR | 83410S108 | BBG00L2DB535 | 911416 | 68476 | SH |  | SOLE |  | 68476 | 0 | 0 |
| Solventum Corp | Common Stock | 83444M101 | BBG018YZH6T3 | 300326 | 3960 | SH |  | SOLE |  | 3960 | 0 | 0 |
| S Global Inc | Common Stock | 78409V104 | BBG000BP1Q11 | 849992 | 1612 | SH |  | DFND |  | 1612 | 0 | 0 |
| SPDR S 500 ETF Trust | ETP | 78462F103 | BBG000BDTBL9 | 10014731 | 16209 | SH |  | SOLE |  | 16209 | 0 | 0 |
| Sarepta Therapeutics Inc | Common Stock | 803607100 | BBG000BCJ161 | 282577 | 16525 | SH |  | SOLE |  | 16525 | 0 | 0 |
| Scholar Rock Holding Corp | Common Stock | 80706P103 | BBG00KT2RRM6 | 394791 | 11146 | SH |  | SOLE |  | 11146 | 0 | 0 |
| STERIS PLC | Common Stock | G8473T100 | BBG00MRHG523 | 322615 | 1343 | SH |  | SOLE |  | 1343 | 0 | 0 |
| Seagate Technology Holdings PL | Common Stock | G7997R103 | BBG0113JGQF0 | 590021 | 4088 | SH |  | SOLE |  | 4088 | 0 | 0 |
| SpringWorks Therapeutics Inc | Common Stock | 85205L107 | BBG00Q011TW9 | 596444 | 12693 | SH |  | SOLE |  | 12693 | 0 | 0 |
| Stryker Corp | Common Stock | 863667101 | BBG000DN7P92 | 619557 | 1566 | SH |  | SOLE |  | 1566 | 0 | 0 |
| AT Inc | Common Stock | 00206R102 | BBG000BSJK37 | 2162918 | 74738 | SH |  | SOLE |  | 74738 | 0 | 0 |
| TAL Education Group | ADR | 874080104 | BBG0016XJ8S0 | 19712397 | 1928806 | SH |  | DFND |  | 1928806 | 0 | 0 |
| TransDigm Group Inc | Common Stock | 893641100 | BBG000L8CBX4 | 222013 | 146 | SH |  | SOLE |  | 146 | 0 | 0 |
| Teledyne Technologies Inc | Common Stock | 879360105 | BBG000BMT9T6 | 454931 | 888 | SH |  | SOLE |  | 888 | 0 | 0 |
| Atlassian Corp | Common Stock | 049468101 | BBG01BGWHFR5 | 781897 | 3850 | SH |  | DFND |  | 3850 | 0 | 0 |
| Bio-Techne Corp | Common Stock | 09073M104 | BBG000C15114 | 282821 | 5497 | SH |  | SOLE |  | 5497 | 0 | 0 |
| TE Connectivity PLC | Common Stock | G87052109 | BBG01Q08MMR1 | 948431 | 5623 | SH |  | SOLE |  | 5623 | 0 | 0 |
| Teradyne Inc | Common Stock | 880770102 | BBG000BV4DR6 | 256722 | 2855 | SH |  | SOLE |  | 2855 | 0 | 0 |
| TG Therapeutics Inc | Common Stock | 88322Q108 | BBG000FVZQY1 | 756114 | 21009 | SH |  | SOLE |  | 21009 | 0 | 0 |
| TJX Cos Inc/The | Common Stock | 872540109 | BBG000BV8DN6 | 352564 | 2855 | SH |  | SOLE |  | 2855 | 0 | 0 |
| ISHARES TR | 20 YR TR BD ETF | 464287432 | BBG000BJKYW3 | 725239 | 8218 | SH |  | SOLE |  | 8218 | 0 | 0 |
| Tencent Music Entertainment Gr | ADR | 88034P109 | BBG00LDC5RK5 | 51037138 | 2618632 | SH |  | DFND |  | 2618632 | 0 | 0 |
| Thermo Fisher Scientific Inc | Common Stock | 883556102 | BBG000BVDLH9 | 647114 | 1596 | SH |  | SOLE |  | 1596 | 0 | 0 |
| T-Mobile US Inc | Common Stock | 872590104 | BBG000NDV1D4 | 6634350 | 27845 | SH |  | DFND |  | 27845 | 0 | 0 |
| Toll Brothers Inc | Common Stock | 889478103 | BBG000BVHBM1 | 543031 | 4758 | SH |  | SOLE |  | 4758 | 0 | 0 |
| Tapestry Inc | Common Stock | 876030107 | BBG000BY29C7 | 1119051 | 12744 | SH |  | SOLE |  | 12744 | 0 | 0 |
| Trimble Inc | Common Stock | 896239100 | BBG000BNPS52 | 354295 | 4663 | SH |  | SOLE |  | 4663 | 0 | 0 |
| Taysha Gene Therapies Inc | Common Stock | 877619106 | BBG00TJXFDP1 | 30524 | 13214 | SH |  | SOLE |  | 13214 | 0 | 0 |
| Tesla Inc | Common Stock | 88160R101 | BBG000N9MNX3 | 23264148 | 73236 | SH |  | DFND |  | 73236 | 0 | 0 |
| Taiwan Semiconductor Manufactu | ADR | 874039100 | BBG000BD8ZK0 | 43473623 | 191945 | SH |  | DFND |  | 191945 | 0 | 0 |
| Trane Technologies PLC | Common Stock | G8994E103 | BBG000BM6788 | 247137 | 565 | SH |  | SOLE |  | 565 | 0 | 0 |
| Trade Desk Inc/The | Common Stock | 88339J105 | BBG00629NGT2 | 750136 | 10420 | SH |  | DFND |  | 10420 | 0 | 0 |
| Take-Two Interactive Software | Common Stock | 874054109 | BBG000BS1YV5 | 1308719 | 5389 | SH |  | DFND |  | 5389 | 0 | 0 |
| Travere Therapeutics Inc | Common Stock | 89422G107 | BBG000P9D6W9 | 204077 | 13789 | SH |  | SOLE |  | 13789 | 0 | 0 |
| Twist Bioscience Corp | Common Stock | 90184D100 | BBG006KDCHJ4 | 310692 | 8445 | SH |  | SOLE |  | 8445 | 0 | 0 |
| Texas Instruments Inc | Common Stock | 882508104 | BBG000BVV7G1 | 7920496 | 38149 | SH |  | DFND |  | 38149 | 0 | 0 |
| Tyler Technologies Inc | Common Stock | 902252105 | BBG000BVWZF9 | 478422 | 807 | SH |  | SOLE |  | 807 | 0 | 0 |
| Uber Technologies Inc | Common Stock | 90353T100 | BBG002B04MT8 | 494956 | 5305 | SH |  | SOLE |  | 5305 | 0 | 0 |
| Universal Health Services Inc | Common Stock | 913903100 | BBG000CB8Q50 | 308136 | 1701 | SH |  | SOLE |  | 1701 | 0 | 0 |
| UnitedHealth Group Inc | Common Stock | 91324P102 | BBG000CH5208 | 3230761 | 10356 | SH |  | SOLE |  | 10356 | 0 | 0 |
| Union Pacific Corp | Common Stock | 907818108 | BBG000BW3299 | 353173 | 1535 | SH |  | SOLE |  | 1535 | 0 | 0 |
| United Therapeutics Corp | Common Stock | 91307C102 | BBG000BV4XJ1 | 1115205 | 3881 | SH |  | SOLE |  | 3881 | 0 | 0 |
| Visa Inc | Common Stock | 92826C839 | BBG000PSKYX7 | 6344033 | 17868 | SH |  | SOLE |  | 17868 | 0 | 0 |
| Vericel Corp | Common Stock | 92346J108 | BBG000BDCM24 | 224962 | 5287 | SH |  | SOLE |  | 5287 | 0 | 0 |
| Veracyte Inc | Common Stock | 92337F107 | BBG001J2M542 | 328333 | 12147 | SH |  | SOLE |  | 12147 | 0 | 0 |
| Vipshop Holdings Ltd | ADR | 92763W103 | BBG002NLDLV8 | 21769208 | 1446459 | SH |  | DFND |  | 1446459 | 0 | 0 |
| Vir Biotechnology Inc | Common Stock | 92764N102 | BBG00H2QQ8T5 | 74078 | 14698 | SH |  | SOLE |  | 14698 | 0 | 0 |
| Viking Therapeutics Inc | Common Stock | 92686J106 | BBG006LGV869 | 465870 | 17580 | SH |  | SOLE |  | 17580 | 0 | 0 |
| Vanguard S 500 ETF | ETP | 922908363 | BBG0015VYNT4 | 531108 | 935 | SH |  | SOLE |  | 935 | 0 | 0 |
| Verisk Analytics Inc | Common Stock | 92345Y106 | BBG000BCZL41 | 1139467 | 3658 | SH |  | DFND |  | 3658 | 0 | 0 |
| VeriSign Inc | Common Stock | 92343E102 | BBG000BGKHZ3 | 445330 | 1542 | SH |  | SOLE |  | 1542 | 0 | 0 |
| Vertiv Holdings Co | Common Stock | 92537N108 | BBG00L2B8KW8 | 1264068 | 9844 | SH |  | DFND |  | 9844 | 0 | 0 |
| Vertex Pharmaceuticals Inc | Common Stock | 92532F100 | BBG000C1S2X2 | 4286386 | 9628 | SH |  | DFND |  | 9628 | 0 | 0 |
| Verastem Inc | Common Stock | 92337C203 | BBG001J2LSK5 | 48555 | 11700 | SH |  | SOLE |  | 11700 | 0 | 0 |
| Viatris Inc | Common Stock | 92556V106 | BBG00Y4RQNH4 | 287894 | 32239 | SH |  | SOLE |  | 32239 | 0 | 0 |
| Verizon Communications Inc | Common Stock | 92343V104 | BBG000HS77T5 | 1896135 | 43821 | SH |  | SOLE |  | 43821 | 0 | 0 |
| Waters Corp | Common Stock | 941848103 | BBG000FQRVM3 | 316928 | 908 | SH |  | SOLE |  | 908 | 0 | 0 |
| Weibo Corp | ADR | 948596101 | BBG0065XPGX9 | 3400390 | 356809 | SH |  | SOLE |  | 356809 | 0 | 0 |
| Warner Bros Discovery Inc | Common Stock | 934423104 | BBG011386VF4 | 718691 | 62713 | SH |  | DFND |  | 62713 | 0 | 0 |
| Workday Inc | Common Stock | 98138H101 | BBG000VC0T95 | 2195760 | 9149 | SH |  | DFND |  | 9149 | 0 | 0 |
| Western Digital Corp | Common Stock | 958102105 | BBG000BWNFZ9 | 426301 | 6662 | SH |  | SOLE |  | 6662 | 0 | 0 |
| Waterdrop Inc | ADR | 94132V105 | BBG0104PNHQ7 | 371686 | 275323 | SH |  | SOLE |  | 275323 | 0 | 0 |
| Welltower Inc | REIT | 95040Q104 | BBG000BKY1G5 | 235976 | 1535 | SH |  | SOLE |  | 1535 | 0 | 0 |
| Wells Fargo  Co | Common Stock | 949746101 | BBG000BWQFY7 | 2712783 | 33859 | SH |  | SOLE |  | 33859 | 0 | 0 |
| Waste Management Inc | Common Stock | 94106L109 | BBG000BWVSR1 | 205938 | 900 | SH |  | SOLE |  | 900 | 0 | 0 |
| Walmart Inc | Common Stock | 931142103 | BBG000BWXBC2 | 4462190 | 45635 | SH |  | SOLE |  | 45635 | 0 | 0 |
| Williams-Sonoma Inc | Common Stock | 969904101 | BBG000FSMWC3 | 883995 | 5411 | SH |  | SOLE |  | 5411 | 0 | 0 |
| West Pharmaceutical Services I | Common Stock | 955306105 | BBG000BX24N8 | 293848 | 1343 | SH |  | SOLE |  | 1343 | 0 | 0 |
| Xcel Energy Inc | Common Stock | 98389B100 | BBG000BCTQ65 | 1019798 | 14975 | SH |  | DFND |  | 14975 | 0 | 0 |
| Xencor Inc | Common Stock | 98401F105 | BBG0026ZG4W0 | 79284 | 10087 | SH |  | SOLE |  | 10087 | 0 | 0 |
| Exxon Mobil Corp | Common Stock | 30231G102 | BBG000GZQ728 | 4838819 | 44887 | SH |  | SOLE |  | 44887 | 0 | 0 |
| Yalla Group Ltd | ADR | 98459U103 | BBG00X71LSZ4 | 380419 | 56442 | SH |  | SOLE |  | 56442 | 0 | 0 |
| Full Truck Alliance Co Ltd | ADR | 35969L108 | BBG01186DLS3 | 45004674 | 3810726 | SH |  | SOLE |  | 3810726 | 0 | 0 |
| Yum China Holdings Inc | Common Stock | 98850P109 | BBG00B8N0HG1 | 6816218 | 152454 | SH |  | SOLE |  | 152454 | 0 | 0 |
| Zimmer Biomet Holdings Inc | Common Stock | 98956P102 | BBG000BKPL53 | 297801 | 3265 | SH |  | SOLE |  | 3265 | 0 | 0 |
| Zebra Technologies Corp | Common Stock | 989207105 | BBG000CC7LQ7 | 279374 | 906 | SH |  | SOLE |  | 906 | 0 | 0 |
| Zhihu Inc | ADR | 98955N207 | BBG00ZKGL1K6 | 777943 | 195463 | SH |  | SOLE |  | 195463 | 0 | 0 |
| Zscaler Inc | Common Stock | 98980G102 | BBG003338H34 | 4751796 | 15136 | SH |  | DFND |  | 15136 | 0 | 0 |
| Zoetis Inc | Common Stock | 98978V103 | BBG0039320N9 | 428707 | 2749 | SH |  | SOLE |  | 2749 | 0 | 0 |
| Cboe Global Markets Inc | Common Stock | 12503M108 | BBG000QH56C1 | 59702 | 256 | SH |  | SOLE |  | 256 | 0 | 0 |
| iShares MSCI Eurozone ETF | ETP | 464286608 | BBG000CS4KW0 | 385295 | 6481 | SH |  | SOLE |  | 6481 | 0 | 0 |

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