# EDGAR Filing Document

**Accession Number:** 0001662579
**File Stem:** 0001628280-26-012002
**Filing Date:** 2026-2
**Character Count:** 34001
**Document Hash:** fdacce769a8c87385ddab24391e59d04
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001628280-26-012002.hdr.sgml**: 20260226

**ACCESSION NUMBER**: 0001628280-26-012002

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 18

**FILED AS OF DATE**: 20260226

**DATE AS OF CHANGE**: 20260226

**EFFECTIVENESS DATE**: 20260226

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** C4 Therapeutics, Inc.
- **CENTRAL INDEX KEY:** 0001662579
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 475617627
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-293775
- **FILM NUMBER:** 26681751

**BUSINESS ADDRESS:**
- **STREET 1:** 490 ARSENAL WAY
- **STREET 2:** SUITE 120
- **CITY:** WATERTOWN
- **STATE:** MA
- **ZIP:** 02472
- **BUSINESS PHONE:** (617) 231-0700

**MAIL ADDRESS:**
- **STREET 1:** 490 ARSENAL WAY
- **STREET 2:** SUITE 120
- **CITY:** WATERTOWN
- **STATE:** MA
- **ZIP:** 02472

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

_____________________________________

**FORM S-8**

**REGISTRATION STATEMENT**

**Under The Securities Act of 1933**

_____________________________________

**C4 Therapeutics, Inc.**

**(Exact name of Registrant as specified in its Charter)**

_____________________________________

---

| | |
|:---|:---|
| **Delaware** | **47-5617627** |
| **(State or other jurisdiction of<br>incorporation or organization)** | **(I.R.S. Employer**<br>**Identification No.)** |
| **490 Arsenal Way, Suite 120**<br>**Watertown, MA** | **02472** |
| **(Address of principal executive offices)** | **(Zip Code)** |

---

_____________________________________

**C4 Therapeutics, Inc. 2020 Stock Option and Incentive Plan**

**C4 Therapeutics, Inc. Non-Qualified Stock Option Agreements for Inducement Awards**

(Full title of the plans)

_____________________________________

---

| |
|:---|
| **Andrew J. Hirsch** |
| **President and Chief Executive Officer** |
| **C4 Therapeutics, Inc.** |
| **490 Arsenal Way, Suite 120** |
| **Watertown, MA 02472** |
| **(617) 231-0700** |

---

(Name, address, including zip code, and telephone number, including area code, of agent for service)

---

| | |
|:---|:---|
| ***Copies to:*** | ***Copies to:*** |
| **Edwin O'Connor, Esq.** | **Shagha Russell** |
| **Shoaib Ghias, Esq.** | **Senior Vice President, General Counsel** |
| **Goodwin Procter LLP** | **C4 Therapeutics, Inc.** |
| **100 Northern Avenue** | **490 Arsenal Way, Suite 120** |
| **Boston, MA 02210** | **Watertown, MA 02472** |
| **((617) 570-1000** | **(617) 231-0700** |

---

________________________________________________________________

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | □ | Accelerated filer | □ |
| Non-accelerated filer | ⌧ | Smaller reporting company | ⌧ |
| | | Emerging growth company | □ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

![image_7.jpg](image_7.jpg)![image_8.jpg](image_8.jpg)

------

**EXPLANATION NOTE**

This Registration Statement on Form S-8 (the "**Registration Statement**") is filed to register the offer and sale of (i) an additional 4,845,720 shares of common stock, $0.0001 par value per share (the **Common Stock**") of C4 Therapeutics, Inc. (the "**Registrant**"), to be issued under the Registrant's 2020 Stock Option and Incentive Plan (the "**Plan**"). The number of shares of Common Stock reserved and available for issuance under the Plan is subject to an automatic annual increase on each January 1, beginning in 2021, by an amount equal to the lesser of: (i) five percent of the number of shares of Common Stock issued and outstanding on the immediately preceding December 31 or (ii) such number of shares of Common Stock as determined by the Administrator (as defined in the Plan). Accordingly, on January 1, 2026, the number of shares of Common Stock reserved and available for issuance under the Plan increased by 4,845,720. The additional shares are of the same class as other securities relating to the Plan for which this Registration Statement incorporates by reference the contents of the (i) <u>[Registration Statement on Form S-8, File No. 333-249286, filed by the Registrant on October 2, 2020](http://www.sec.gov/Archives/edgar/data/1662579/000119312520262640/d60538ds8.htm)</u>, (ii) <u>[Registration Statement on Form S-8, File No. 333-254145, filed by the Registrant on March 11, 2021](http://www.sec.gov/Archives/edgar/data/1662579/000156459021012540/cccc-s8.htm)</u>, (iii) <u>[Registration Statement on Form S-8, File No. 333-262949, filed by the Registrant on February 24, 2022](https://www.sec.gov/Archives/edgar/data/1662579/000156459022006505/cccc-s8.htm)</u>, (iv) <u>[Registration Statement on Form S-8. File 333-269944, filed by the Registrant on February 23, 2023](https://www.sec.gov/Archives/edgar/data/1662579/000162828023004830/a2022s-8.htm)</u>, (v) <u>[Registration Statement on Form S-8. File 333-277245, filed by the Registrant on February 22, 2024](https://www.sec.gov/Archives/edgar/data/1662579/000162828024006168/a2023s-8.htm)</u>, and (vi) <u>[Registration Statement on Form S-8. File 333-285304, filed by the Registrant on February 27, 2025](https://www.sec.gov/Archives/edgar/data/1662579/000162828025008434/a2025s-8.htm)</u> relating to the Registrant's 2015 Stock Option and Grant Plan, the Plan and the Registrant's 2020 Employee Stock Purchase Plan, pursuant to General Instruction E.

This Registration Statement on Form S-8 is also filed for the purpose of registering 248,360 shares of the Registrant's Common Stock issuable under previously announced inducement stock option awards granted on January 26, 2026 and February 9, 2026 (the "**Inducement Awards**"). The Inducement Awards were granted outside of the Plan.

**Part I**

**INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS** 

**Item 1.**&nbsp;&nbsp;&nbsp;&nbsp;**Plan Information.**

The documents containing the information specified in this Item 1 will be sent or given to (i) participants in the equity benefit plan covered by this Registration Statement and (ii) the employees issued the Inducement Awards as specified by Rule 428(b)(1) under the Securities Act of 1933, as amended (the "**Securities Act**"). In accordance with the rules and regulations of the Securities and Exchange Commission (the "**Commission**") and the instructions to Form S-8, such documents are not being filed with the Commission either as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424 under the Securities Act.

**Item 2.**&nbsp;&nbsp;&nbsp;&nbsp;**Registrant Information and Employee Plan Annual Information.**

The documents containing the information specified in this Item 2 will be sent or given to (i) participants in the equity benefit plan covered by this Registration Statement and (ii) the employees issued the Inducement Awards as specified by Rule 428(b)(1) under the Securities Act. In accordance with the rules and regulations of the Commission and the instructions to Form S-8, such documents are not being filed with the Commission either as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424 under the Securities Act.

**PART II**

**Information Required in the Registration Statement**

**Item 3.**&nbsp;&nbsp;&nbsp;&nbsp;**Incorporation of Documents by Reference.**

The Registrant hereby incorporates by reference into this Registration Statement the following documents filed with the Commission:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) The Registrant's Annual Report on Form 10-K for the year ended December 31, 2025, filed with the Commission on February 26, 2026.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) The description of the Registrant's Common Stock contained in its Registration Statement on Form 8-A, filed with the Commission on September 28, 2020, and any amendment or report filed with the Commission for the purpose of updating the description.

All documents that the Registrant subsequently files pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the filing of a post-effective amendment to this Registration Statement which indicates that all of the shares of Common Stock offered have been sold or which deregisters all of such shares then remaining unsold, shall be deemed to be incorporated by reference in this Registration Statement and to be a part hereof from the date of the filing of such documents.

------

Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement. Under no circumstances will any information furnished under current items 2.02 or 7.01 of Form 8-K be deemed incorporated herein by reference unless such Form 8-K expressly provides to the contrary.

**Item 4.**&nbsp;&nbsp;&nbsp;&nbsp;**Description of Services.**

Not applicable.

**Item 5.**&nbsp;&nbsp;&nbsp;&nbsp;**Interests of Named Experts and Counsel.**

Not applicable.

**Item 6.**&nbsp;&nbsp;&nbsp;&nbsp;**Indemnification of Directors and Officers.**

Section 145 of the Delaware General Corporation Law (the "**DGCL**") authorizes a corporation to indemnify its directors and officers against liabilities arising out of actions, suits and proceedings to which they are made or threatened to be made a party by reason of the fact that they have served or are currently serving as a director or officer to a corporation. The indemnity may cover expenses (including attorneys' fees) judgments, fines and amounts paid in settlement actually and reasonably incurred by the director or officer in connection with any such action, suit or proceeding. Section 145 permits corporations to pay expenses (including attorneys' fees) incurred by directors and officers in advance of the final disposition of such action, suit or proceeding. In addition, Section 145 provides that a corporation has the power to purchase and maintain insurance on behalf of its directors and officers against any liability asserted against them and incurred by them in their capacity as a director or officer, or arising out of their status as such, whether or not the corporation would have the power to indemnify the director or officer against such liability under Section 145.

We have adopted provisions in our fifth amended and restated certificate of incorporation, as amended to date, and second amended and restated bylaws that limit or eliminate the personal liability of our directors to the fullest extent permitted by the DGCL, as it now exists or may in the future be amended. Consequently, a director will not be personally liable to us or our stockholders for monetary damages or breach of fiduciary duty as a director, except for liability for:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• any breach of the director's duty of loyalty to us or our stockholders;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• any act or omission not in good faith or that involves intentional misconduct or a knowing violation of law;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• any unlawful payments related to dividends or unlawful stock purchases, redemptions or other distributions; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• any transaction from which the director derived an improper personal benefit.

These limitations of liability do not alter director liability under the federal securities laws and do not affect the availability of equitable remedies such as an injunction or rescission.

In addition, our bylaws provide that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• we will indemnify our directors, officers and, in the discretion of our board of directors, certain employees to the fullest extent permitted by the DGCL, as it now exists or may in the future be amended; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• we will advance reasonable expenses, including attorneys' fees, to our directors and, in the discretion of our board of directors, to our officers and certain employees, in connection with legal proceedings relating to their service for or on behalf of us, subject to limited exceptions.

We have entered into indemnification agreements with each of our directors and our executive officers. These agreements provide that we will indemnify each of our directors, our executive officers and, at times, their affiliates to the fullest extent permitted by Delaware law. We will advance expenses, including attorneys' fees (but excluding judgments, fines and settlement amounts), to each indemnified director, executive officer or affiliate in connection with any proceeding in which indemnification is available and we will indemnify our directors and officers for any action or proceeding arising out of that person's services as a director or officer brought on behalf of us or in furtherance of our rights. Additionally, certain of our directors or officers may have certain rights to indemnification, advancement of expenses or insurance provided by their affiliates or other third parties, which indemnification relates to and might apply to the same proceedings arising out of such director's or officer's services as a director referenced herein. Nonetheless, we have agreed in the indemnification agreements that our obligations to those same directors or officers are primary and any obligation of such affiliates or other third parties to advance expenses or to provide indemnification for the expenses or liabilities incurred by those directors are secondary.

------

We also maintain general liability insurance which covers certain liabilities of our directors and officers arising out of claims based on acts or omissions in their capacities as directors or officers, including liabilities under the Securities Act.

**Item 7.**&nbsp;&nbsp;&nbsp;&nbsp;**Exhibits Exemption from Registration Claimed.**

Not applicable.

**Item 8.**&nbsp;&nbsp;&nbsp;&nbsp;**Exhibits**

Refer to the Exhibit Index on the next page for a list of exhibits filed as part of this registration statement, which Exhibit Index is incorporated herein by reference.

![image_9.jpg](image_9.jpg)![image_10.jpg](image_10.jpg)![image_8.jpg](image_8.jpg)

------

**EXHIBIT INDEX**

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| **Exhibit**<br>**No.** | **Description of Exhibit** | **Form** | **File<br>Number** | **Date of<br>Filing** | **Exhibit<br>No.** | **Filed<br>Herewith** |
| 4.1 | [Fifth Amended and Restated Certificate of Incorporation of the Registrant](http://www.sec.gov/Archives/edgar/data/1662579/000119312520264807/d17027dex31.htm) | 8-K | 001-39567 | 10/06/2020 | 3.1 |  |
| 4.2 | [Certificate of Amendment to the Fifth Amended and Restated Certificate of Incorporation of the Registrant](https://www.sec.gov/ix?doc=/Archives/edgar/data/0001662579/000162828023013738/cccc-20230427.htm) | DEF14A | 001-39567 | 04/28/2023 | A |  |
| 4.3 | [Certificate of Amendment to the Fifth Amended and Restated Certificate of Incorporation of the Registrant](https://www.sec.gov/Archives/edgar/data/1662579/000162828025032155/c4t-certificateofamendme.htm) | 8-K | 001-39567 | 06/18/2025 | 3.1 |  |
| 4.4 | [Second Amended and Restated Bylaws of the Registrant](http://www.sec.gov/Archives/edgar/data/1662579/000119312520243234/d772024dex35.htm) | S-1 | 333-248719 | 09/10/2020 | 3.5 |  |
| 5.1 | [Opinion of Goodwin Procter LLP](s-82026xexhibit51.htm) |  |  |  |  | X |
| 23.1 | [Consent of Goodwin Procter LLP (included in Exhibit 5.1)](s-82026xexhibit51.htm) |  |  |  |  | X |
| 23.2 | [Consent of KPMG LLP, Independent Registered Public Accounting Firm](s-82026xexhibit232.htm) |  |  |  |  | X |
| 24.1 | [Power of attorney (included on the signature pages of this registration statement)](#i51acbf80b3fa4948a2a5778b7ea19bd3_10) |  |  |  |  | X |
| 99.1 | [2020 Stock Option and Incentive Plan and forms of award agreements thereunder](https://www.sec.gov/Archives/edgar/data/1662579/000162828023004711/exhibit102.htm) | 10-K | 001-39567 | 02/23/2023 | 10.2 |  |
| 99.2 | [Form of Non-Qualified Stock Option Agreement Inducement Award](https://www.sec.gov/Archives/edgar/data/1662579/000162828024006144/c4t-formofnsoagreementin.htm) | 10-K | 001-39567 | 02/22/2024 | 10.19 |  |
| 107 | <u>[Filing Fee Table](s8filingfees2026.htm)</u> |  |  |  |  | X |

---

___________________

![image_8.jpg](image_8.jpg)

**Item 9.**&nbsp;&nbsp;&nbsp;&nbsp;**Undertakings.**

(a) The registrant hereby undertakes:

(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:

(i) To include any prospectus required by Section 10(a)(3) of the Securities Act.

(ii) To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20% change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective registration statement.

(iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement.

*Provided, however*, that paragraphs (a)(1)(i) and (a)(1)(ii) herein do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the registrant pursuant to Section 13 or Section 15(d) of the Exchange Act (15 U.S.C. 78m or 78o(d)) that are incorporated by reference in the registration statement.

(2) That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

(3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

------

(b) The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

(h) Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.

------

**SIGNATURES**

Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Watertown, Commonwealth of Massachusetts, on this 26th day of February 2026.

---

| | | |
|:---|:---|:---|
| | C4 Therapeutics, Inc. | C4 Therapeutics, Inc. |
| Date: February 26, 2026 | By: | /s/ Andrew J. Hirsch |
|  |  | **Andrew J. Hirsch** |
|  |  | **President and Chief Executive Officer** |

---

**POWER OF ATTORNEY AND SIGNATURES**

KNOW ALL BY THESE PRESENT, that each individual whose signature appears below hereby constitutes and appoints each of Andrew J. Hirsch and Kendra R. Adams as such person's true and lawful attorney-in-fact and agent with full power of substitution and resubstitution, for such person in such person's name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement on Form S-8, and to file the same, with all exhibits thereto, and all documents in connection therewith, with the Securities and Exchange Commission granting unto each said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as such person might or could do in person, hereby ratifying and confirming all that any said attorney-in-fact and agent, or any substitute or substitutes of any of them, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following person in the capacities and on the date indicated.

---

| | | |
|:---|:---|:---|
| **Name** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**Title** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**Date** |
| /s/ Andrew J. Hirsch | President, Chief Executive Officer, and Director | February 26, 2026 |
| **Andrew J. Hirsch** | (Principal Executive Officer) |  |
| /s/ Kendra R. Adams | Chief Financial Officer and Treasurer | February 26, 2026 |
| **Kendra R. Adams** | (Principal Financial Officer) |  |
| /s/ Mark Mossler | Chief Accounting Officer | February 26, 2026 |
| **Mark Mossler** | (Principal Accounting Officer) |  |
| /s/ Ronald Cooper | Chairman and Director | February 26, 2026 |
| **Ronald Cooper** |  |  |
| /s/ Kenneth C. Anderson, M.D. | Director | February 26, 2026 |
| **Kenneth C. Anderson, M.D.** |  |  |
| /s/ Laura Bessen, M.D. | Director | February 26, 2026 |
| **Laura Bessen, M.D.** |  |  |
| /s/ Stephen Fawell, Ph.D. | Director | February 26, 2026 |
| **Stephen Fawell, Ph.D.** |  |  |
| /s/ Donna Grogan, M.D. | Director | February 26, 2026 |
| **Donna Grogan, M.D.** |  |  |
| /s/ Stephen L. Hoerter. | Director | February 26, 2026 |
| **Stephen L. Hoerter** |  |  |
| /s/ Owen Hughes | Director | February 26, 2026 |
| **Owen Hughes** |  |  |
| /s/ Utpal Koppikar | Director | February 26, 2026 |
| **Utpal Koppikar** |  |  |

---

## Ex-Filing

?xml version='1.0' encoding='ASCII'? EX-FILING FEES

---

| |
|:---|
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Calculation of Filing Fee Tables**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **S-8**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **C4 Therapeutics, Inc.**  |

---

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Security Type**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Security Class Title**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Fee Calculation Rule**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Amount Registered**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Proposed Maximum Offering Price Per Unit**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Maximum Aggregate Offering Price**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Fee Rate**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Amount of Registration Fee**  |
| 1 | Equity | Common Stock, par value $0.0001 per share | Other | 4845720 | $2.00 | $9691440.00 | 0.0001381 | $1338.39 |
| 2 | Equity | Common Stock, par value $0.0001 per share | Other | 248360 | $1.88 | $466916.80 | 0.0001381 | $64.48 |
| Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: |  | $10158356.80  |  | $1402.87  |
| Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  |  |  |  | $0.00  |
| Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  |  |  |  | $1402.87  |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Offering Note** <br>

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <sup>1</sup> (1) Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement on Form S-8 ("Registration Statement") shall also cover any additional shares of common stock, $0.0001 par value per share (the "Common Stock") of C4 Therapeutics, Inc. (the "Registrant") that become issuable under the Registrant's 2020 Stock Option and Incentive Plan (the "2020 Plan") by reason of any stock dividend, stock split, recapitalization or any other similar transactions. (2) Represents 4,845,720 shares of Common issuable under the 2020 Plan, which represents the automatic annual increase to the number of shares available for issuance under the 2020 Plan effective as of January 1, 2026. (3) Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and 457(h) of the Securities Act of 1933, as amended. The price per share and aggregate offering price are calculated based on the average of the high and low price of the registrant's Common Stock as reported on the NASDAQ Global Select Market on February 19, 2026.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <sup>2</sup> (1) Pursuant to Rule 416 under the Securities Act, this Registration Statement shall also cover any additional shares of Common Stock of the Registrant that may from time to time be offered or issued by reason of any stock dividend, stock split, recapitalization or any other similar transactions. (2) Represents the aggregate number of shares of the registrant's common stock issuable under new hire inducement stock option awards granted under Nasdaq Listing Rule 5635(c)(4). (3) Estimated in accordance with Rule 457(h) of the Securities Act, solely for the purpose of calculating the registration fee, based on the weighted average exercise price of the applicable inducement stock option award.

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| | |
|:---|:---|
| | |
| **Rule 457(p)** | **Rule 457(p)** |
| Fee Offset Claims | N/A |
| Fee Offset Sources | N/A |

---

## Exhibit 5.1

**Exhibit 5.1**

February 26, 2026

C4 Therapeutics, Inc.

490 Arsenal Way, Suite 120

Watertown, MA 02472

Re: <u>Securities Being Registered under Registration Statement on Form S-8</u>

We have acted as your counsel in connection with your filing of a Registration Statement on Form S-8 (the "Registration Statement") pursuant to the Securities Act of 1933, as amended (the "Securities Act"), on or about the date hereof relating to (i) an aggregate of 4,845,720 shares (the "Plan Shares") of Common Stock, par value $0.0001 per share ("Common Stock"), of C4 Therapeutics, Inc., a Delaware corporation (the "Company"), that may be issued pursuant to the Company's 2020 Stock Option and Incentive Plan (the "Plan") and (ii) 248,360 shares of Common Stock of the Company (the "Award Shares" and, together with the Plan Shares, the "Shares"), that may be issued pursuant to the Inducement Stock Option Agreements, (the " Award Agreements"), between the Company and certain of its employees, for awards granted on January 26, 2026 and February 9, 2026.

We have reviewed such documents and made such examination of law as we have deemed appropriate to give the opinion set forth below. We have relied, without independent verification, on certificates of public officials and, as to matters of fact material to the opinion set forth below, on certificate of an officer of the Company.

For purposes of the opinion set forth below, we have assumed that, at the time Shares are issued, the total number of then unissued Shares, when added to the number of shares of Common Stock issued, subscribed for, or otherwise committed to be issued, does not exceed the number of shares of Common Stock authorized by the Company's certificate of incorporation.

The opinion set forth below is limited to the Delaware General Corporation Law.

Based on the foregoing, we are of the opinion that the Shares have been duly authorized and, when delivered against payment therefor in accordance with the terms of the Plan, with respect to the Plan Shares, or the Award Agreements, with respect to the Award Shares, will be validly issued, fully paid and nonassessable.

This opinion letter and the opinion it contains shall be interpreted in accordance with the Core Opinion Principles as published in 74 *Business Lawyer* 815 (Summer 2019).

We hereby consent to the inclusion of this opinion as Exhibit 5.1 to the Registration Statement. In giving our consent, we do not admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations thereunder.

Very truly yours,

/s/ Goodwin Procter LLP

GOODWIN PROCTER LLP

## Exhibit 23.2

**Exhibit 23.2**

**Consent of Independent Registered Public Accounting Firm**

The Board of Directors

C4 Therapeutics, Inc.:

We consent to the use of our report dated February 26, 2026, with respect to the consolidated financial statements of C4 Therapeutics, Inc., incorporated herein by reference.

/s/ KPMG LLP

Boston, Massachusetts

February 26, 2026

<br>