# EDGAR Filing Document

**Accession Number:** 0001424958
**File Stem:** 0001193125-25-333783
**Filing Date:** 2025-12
**Character Count:** 23950
**Document Hash:** c1f0410ec533d07e498d424b9260ae69
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-25-333783.hdr.sgml**: 20251229

**ACCESSION NUMBER**: 0001193125-25-333783

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20251031

**FILED AS OF DATE**: 20251229

**DATE AS OF CHANGE**: 20251229

**PERIOD START**: 20251031

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Direxion Shares ETF Trust
- **CENTRAL INDEX KEY:** 0001424958

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1031

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-22201
- **FILM NUMBER:** 251605885

**BUSINESS ADDRESS:**
- **STREET 1:** 535 MADISON AVENUE
- **STREET 2:** 37TH FL.
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10022
- **BUSINESS PHONE:** 646-572-3390

**MAIL ADDRESS:**
- **STREET 1:** 535 MADISON AVENUE
- **STREET 2:** 37TH FL.
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10022

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Direxion ETF Trust
- **DATE OF NAME CHANGE:** 20080124

## Series and Classes Contracts Data

### Direxion Daily Pharmaceutical & Medical Bull 3X Shares (Series ID: S000050532)

| Class ID   | Class Name                                             | Ticker Symbol   |
|:---|:---|:---|
| C000159441 | Direxion Daily Pharmaceutical & Medical Bull 3X Shares | PILL            |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** Direxion Shares ETF Trust

- **b. Investment Company Act file number:** 811-22201

- **c. CIK number of Registrant:** 0001424958

- **d. LEI of Registrant:** 549300M501IVJM50FG12

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 1301 Avenue of the Americas (6th Avenue)

  - **City:** New York

  - **State:** NY

  - **Foreign country:** US

  - **Zip / Postal Code:** 10019

  - **Telephone number:** 646-572-3390

**Item A.2. Information about the Series.**

- **a. Name of Series:** Direxion Daily Pharmaceutical & Medical Bull 3X Shares

- **b. EDGAR series identifier (if any):** S000050532

- **c. LEI of Series:** 549300HLYIVQQ31NJC71

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2025-10-31

- **b. Date as of which information is reported:** 2025-10-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $15506977.50

**Total Liabilities:** $3541689.17

**Net Assets:** $11965288.33

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000159441 | 48.58%               | 2.27%                | 9.43%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $0.02                    | $907505.62                                 |
| Month 2  | $36657.43                | $70765.93                                  |
| Month 3  | $86678.84                | $196532.08                                 |

### Schedule of Portfolio Investments

| Name                                | Title                                                               | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| ANI Pharmaceuticals Inc.            | ANI Pharmaceuticals Inc. COM USD0.0001                              | CUSIP: 00182C103<br>LEI: 5493000T6CXTND40YH31 | Long             | EC               | CORP              | US        |      2116 | NS      | $191709.60    | 1.60%             |  |  |  | No            |                  1 | On Loan: No      |
| Amneal Pharmaceuticals Inc          | AMNEAL PHARMACEUTICALS INC                                          | CUSIP: 03168L105<br>LEI: 549300VV176ZO5WQHZ61 | Long             | EC               | CORP              | US        |     14725 | NS      | $159324.50    | 1.33%             |  |  |  | No            |                  1 | On Loan: No      |
| Amphastar Pharmaceuticals Inc       | Amphastar Pharmaceuticals Inc COM USD0.0001                         | CUSIP: 03209R103<br>LEI: 54930055TH0ZLSAQMJ38 | Long             | EC               | CORP              | US        |      4573 | NS      | $116611.50    | 0.97%             |  |  |  | No            |                  1 | On Loan: No      |
| Amylyx Pharmaceuticals Inc          | AMYLYX PHARMACEUTICALS INC                                          | CUSIP: 03237H101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8492 | NS      | $118293.56    | 0.99%             |  |  |  | No            |                  1 | On Loan: No      |
| Arvinas Inc                         | Arvinas Inc COM USD0.001                                            | CUSIP: 04335A105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     12866 | NS      | $130461.24    | 1.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Axsome Therapeutics Inc.            | Axsome Therapeutics Incorporation COM USD0.0001                     | CUSIP: 05464T104<br>LEI: 549300EXGR0XLRJEIB95 | Long             | EC               | CORP              | US        |      1661 | NS      | $224218.39    | 1.87%             |  |  |  | No            |                  1 | On Loan: No      |
| Bristol-Myers Squibb Company        | Bristol-Myers Squibb Company COM USD0.10                            | CUSIP: 110122108<br>LEI: HLYYNH7UQUORYSJQCN42 | Long             | EC               | CORP              | US        |      4373 | NS      | $201464.11    | 1.68%             |  |  |  | No            |                  1 | On Loan: No      |
| Collegium Pharmaceutical Inc.       | Collegium Pharmaceutical Inc. COM USD0.001                          | CUSIP: 19459J104<br>LEI: 54930049FXZMTLW8D496 | Long             | EC               | CORP              | US        |      3011 | NS      | $108396.00    | 0.91%             |  |  |  | No            |                  1 | On Loan: No      |
| Corcept Therapeutics Inc.           | Corcept Therapeutics Inc. COM STK USD0.00001                        | CUSIP: 218352102<br>LEI: 529900EO9LUTFMZ7FF90 | Long             | EC               | CORP              | US        |      2879 | NS      | $211520.13    | 1.77%             |  |  |  | No            |                  1 | On Loan: No      |
| CorMedix Inc.                       | CORMEDIX INC                                                        | CUSIP: 21900C308<br>LEI: 5299006YIA3L0MBW8358 | Long             | EC               | CORP              | US        |     14290 | NS      | $159047.70    | 1.33%             |  |  |  | No            |                  1 | On Loan: —       |
| Crinetics Pharmaceuticals Inc.      | CRINETICS PHARMACEUTICALS IN                                        | CUSIP: 22663K107<br>LEI: 549300Q1CNFXK5P31D28 | Long             | EC               | CORP              | US        |      5892 | NS      | $256302.00    | 2.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Edgewise Therapeutics Inc.          | EDGEWISE THERAPEUTICS INC                                           | CUSIP: 28036F105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7390 | NS      | $135089.20    | 1.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Elanco Animal Health Inc            | Elanco Animal Health Inc COM NPV                                    | CUSIP: 28414H103<br>LEI: 549300SHPNDCE059M934 | Long             | EC               | CORP              | US        |     11249 | NS      | $249165.35    | 2.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Enliven Therapeutics Inc            | ENLIVEN THERAPEUTICS INC                                            | CUSIP: 29337E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5490 | NS      | $128575.80    | 1.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Esperion Therapeutics Inc           | ESPERION THERAPEUTICS INC                                           | CUSIP: 29664W105<br>LEI: 549300OFU56UKEWVUS92 | Long             | EC               | CORP              | US        |     26937 | NS      | $80002.89     | 0.67%             |  |  |  | No            |                  1 | On Loan: No      |
| Evolus Inc                          | EVOLUS INC                                                          | CUSIP: 30052C107<br>LEI: 549300VYQRYBQOT8V419 | Long             | EC               | CORP              | US        |     11920 | NS      | $77003.20     | 0.64%             |  |  |  | No            |                  1 | On Loan: No      |
| EyePoint Pharmaceuticals Inc.       | EYEPOINT PHARMACEUTICALS INC                                        | CUSIP: 30233G209<br>LEI: 549300QE1RU34T50MR69 | Long             | EC               | CORP              | US        |      5898 | NS      | $77204.82     | 0.65%             |  |  |  | No            |                  1 | On Loan: No      |
| Harmony Biosciences Holdings Inc    | Harmony Biosciences Holdings Inc COM                                | CUSIP: 413197104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6209 | NS      | $177391.13    | 1.48%             |  |  |  | No            |                  1 | On Loan: No      |
| Harrow Inc                          | HARROW INC                                                          | CUSIP: 415858109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4358 | NS      | $164601.66    | 1.38%             |  |  |  | No            |                  1 | On Loan: —       |
| Innoviva Inc                        | Innoviva Inc COM USD0.01                                            | CUSIP: 45781M101<br>LEI: 549300ACOX4QTBES6535 | Long             | EC               | CORP              | US        |      9874 | NS      | $179706.80    | 1.50%             |  |  |  | No            |                  1 | On Loan: No      |
| ALT5 Sigma Corporation              | ALT5 SIGMA CORP                                                     | CUSIP: 47089W104<br>LEI: 549300FLMHTQ5MK4YD23 | Long             | EC               | CORP              | US        |      7253 | NS      | $18277.56     | 0.15%             |  |  |  | No            |                  1 | On Loan: —       |
| Johnson & Johnson                   | Johnson & Johnson COM USD1.00                                       | CUSIP: 478160104<br>LEI: 549300G0CFPGEF6X2043 | Long             | EC               | CORP              | US        |      1173 | NS      | $221544.51    | 1.85%             |  |  |  | No            |                  1 | On Loan: No      |
| Zevra Therapeutics Inc              | ZEVRA THERAPEUTICS INC                                              | CUSIP: 488445206<br>LEI: 254900CU6T74V18Y1W18 | Long             | EC               | CORP              | US        |     11326 | NS      | $115298.68    | 0.96%             |  |  |  | No            |                  1 | On Loan: No      |
| Lenz Therapeutics Inc               | LENZ THERAPEUTICS INC                                               | CUSIP: 52635N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3141 | NS      | $93350.52     | 0.78%             |  |  |  | No            |                  1 | On Loan: —       |
| Ligand Pharmaceuticals Incorporated | Ligand Pharmaceuticals Incorporated 'B'COM USD0.001                 | CUSIP: 53220K504<br>LEI: 5493008K7TB0IKP37H79 | Long             | EC               | CORP              | US        |      1242 | NS      | $237607.02    | 1.99%             |  |  |  | No            |                  1 | On Loan: —       |
| Eli Lilly & Co.                     | Eli Lilly & Co. COM NPV                                             | CUSIP: 532457108<br>LEI: FRDRIPF3EKNDJ2CQJL29 | Long             | EC               | CORP              | US        |       274 | NS      | $236423.64    | 1.98%             |  |  |  | No            |                  1 | On Loan: No      |
| Liquidia Corporation                | LIQUIDIA CORP                                                       | CUSIP: 53635D202<br>LEI: 549300O826O5VQJTG707 | Long             | EC               | CORP              | US        |      7555 | NS      | $184039.80    | 1.54%             |  |  |  | No            |                  1 | On Loan: —       |
| Merck & Co., Inc                    | Merck & Co., Inc COM USD0.50                                        | CUSIP: 58933Y105<br>LEI: 4YV9Y5M8S0BRK1RP0397 | Long             | EC               | CORP              | US        |      2454 | NS      | $210994.92    | 1.76%             |  |  |  | No            |                  1 | On Loan: No      |
| Mind Medicine (MindMed) Inc.        | MIND MEDICINE MINDMED INC                                           | CUSIP: 60255C885<br>LEI: 549300QY8KN1O6RPFJ13 | Long             | EC               | CORP              | CA        |     12085 | NS      | $171607.00    | 1.43%             |  |  |  | No            |                  1 | On Loan: No      |
| Nektar Therapeutics                 | NEKTAR THERAPEUTICS                                                 | CUSIP: 640268306<br>LEI: 5299005I24806IOIYE03 | Long             | EC               | CORP              | US        |      2093 | NS      | $135898.49    | 1.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvation Bio Inc                    | NUVATION BIO INC                                                    | CUSIP: 67080N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     38049 | NS      | $198615.78    | 1.66%             |  |  |  | No            |                  1 | On Loan: —       |
| Ocular Therapeutix Inc              | OCULAR THERAPEUTIX INC                                              | CUSIP: 67576A100<br>LEI: 529900ABAWFXOHSIHG03 | Long             | EC               | CORP              | US        |     15800 | NS      | $184228.00    | 1.54%             |  |  |  | No            |                  1 | On Loan: No      |
| Organon & Co                        | Organon & Co COMMON STOCK                                           | CUSIP: 68622V106<br>LEI: 549300AMCKY57OK2CO56 | Long             | EC               | CORP              | US        |     20096 | NS      | $135648.00    | 1.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Pacira Biosciences Inc              | Pacira Biosciences Inc COM USD0.001                                 | CUSIP: 695127100<br>LEI: 549300P56LERYBDHCF69 | Long             | EC               | CORP              | US        |      5989 | NS      | $128044.82    | 1.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Pfizer Inc.                         | Pfizer Inc. COM USD0.05                                             | CUSIP: 717081103<br>LEI: 765LHXWGK1KXCLTFYQ30 | Long             | EC               | CORP              | US        |      8392 | NS      | $206862.80    | 1.73%             |  |  |  | No            |                  1 | On Loan: No      |
| Phathom Pharmaceuticals Inc         | PHATHOM PHARMACEUTICALS INC                                         | CUSIP: 71722W107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7968 | NS      | $107966.40    | 0.90%             |  |  |  | No            |                  1 | On Loan: No      |
| Phibro Animal Health Corporation    | PHIBRO ANIMAL HEALTH CORP-A                                         | CUSIP: 71742Q106<br>LEI: 549300U24SP4AF2JUX52 | Long             | EC               | CORP              | US        |      2241 | NS      | $94256.46     | 0.79%             |  |  |  | No            |                  1 | On Loan: No      |
| Prestige Consumer Healthcare Inc    | Prestige Consumer Healthcare Inc COM USD0.01                        | CUSIP: 74112D101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3170 | NS      | $192102.00    | 1.61%             |  |  |  | No            |                  1 | On Loan: No      |
| Supernus Pharmaceuticals, Inc       | Supernus Pharmaceuticals, Inc COM USD0.001                          | CUSIP: 868459108<br>LEI: 549300GRM36VBKISYJ58 | Long             | EC               | CORP              | US        |      4462 | NS      | $245990.06    | 2.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Tarsus Pharmaceuticals Inc          | TARSUS PHARMACEUTICALS INC                                          | CUSIP: 87650L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3795 | NS      | $261133.95    | 2.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Terns Pharmaceuticals Inc.          | TERNS PHARMACEUTICALS INC                                           | CUSIP: 880881107<br>LEI: 254900S1ZDQMF4MYP709 | Long             | EC               | CORP              | US        |      7992 | NS      | $66013.92     | 0.55%             |  |  |  | No            |                  1 | On Loan: —       |
| Trevi Therapeutics Inc              | TREVI THERAPEUTICS INC                                              | CUSIP: 89532M101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     12935 | NS      | $150822.10    | 1.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Viatris Inc                         | Viatris Inc COM                                                     | CUSIP: 92556V106<br>LEI: 254900ZZTSW7NL773X71 | Long             | EC               | CORP              | US        |     20136 | NS      | $208608.96    | 1.74%             |  |  |  | No            |                  1 | On Loan: No      |
| Xeris Biopharma Holdings Inc        | XERIS BIOPHARMA HOLDINGS INC                                        | CUSIP: 98422E103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     16601 | NS      | $161029.70    | 1.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Zoetis Inc.                         | Zoetis Inc. COM USD0.01 CL 'A'                                      | CUSIP: 98978V103<br>LEI: 549300HD9Q1LOC9KLJ48 | Long             | EC               | CORP              | US        |      1380 | NS      | $198844.20    | 1.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Avadel Pharmaceuticals PLC          | AVADEL PHARMACEUTICALS                                              | CUSIP: G29687103<br>LEI: 549300E27PTSG2RHC762 | Long             | EC               | CORP              | IE        |     10227 | NS      | $193188.03    | 1.61%             |  |  |  | No            |                  1 | On Loan: No      |
| Jazz Pharmaceuticals PLC            | Jazz Pharmaceuticals PLC COM USD0.0001                              | CUSIP: G50871105<br>LEI: 635400GAUMJCLEZRRV50 | Long             | EC               | CORP              | IE        |      1625 | NS      | $223665.00    | 1.87%             |  |  |  | No            |                  1 | On Loan: No      |
| Royalty Pharma PLC                  | Royalty Pharma PLC COM USD0.0001 CLASS A                            | CUSIP: G7709Q104<br>LEI: 549300FGFN7VOK8BZR03 | Long             | EC               | CORP              | GB        |      5699 | NS      | $213940.46    | 1.79%             |  |  |  | No            |                  1 | On Loan: No      |
| Theravance Biopharma Inc            | THERAVANCE BIOPHARMA INC                                            | CUSIP: G8807B106<br>LEI: 5493007VTSXP4Z6MIW52 | Long             | EC               | CORP              | KY        |      1916 | NS      | $28088.56     | 0.23%             |  |  |  | No            |                  1 | On Loan: —       |
| Perrigo Company PLC                 | Perrigo Company PLC COM EUR0.001                                    | CUSIP: G97822103<br>LEI: 549300IFOQS6R1QLY196 | Long             | EC               | CORP              | IE        |      9321 | NS      | $193317.54    | 1.62%             |  |  |  | No            |                  1 | On Loan: No      |
| DREYFUS GOVERNMENT CASH MANAGE      | DREYFUS GOV'T CASH MGMT -INSTITUTIONAL CUSIP 262006208 DGCXX (#289) | CUSIP: N/A<br>LEI: N/A                        | Long             | STIV             | RF                | US        |   1370667 | PA      | $1370667.28   | 11.46%            |  |  |  | No            |                  1 | On Loan: No      |
| GOLDMAN FINANCIAL                   | GOLDMAN FINL SQ TRSRY INST 506                                      | CUSIP: N/A<br>LEI: 549300DAH6N80PM31E83       | Long             | STIV             | RF                | US        |   1353743 | PA      | $1353742.74   | 11.31%            |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                 | S&P PHARMACEUTICALS SELECT INDEX SWAP                               | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |         1 | NC      | $2198546.39   | 18.37%            |  |  |  | No            |                  2 | On Loan: No      |
| N/A                                 | S&P PHARMACEUTICALS SELECT INDEX SWAP                               | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |         1 | NC      | $145916.17    | 1.22%             |  |  |  | No            |                  2 | On Loan: No      |
| N/A                                 | S&P PHARMACEUTICALS SELECT INDEX SWAP                               | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |         1 | NC      | $1245574.26   | 10.41%            |  |  |  | No            |                  2 | On Loan: No      |
| GOLDMAN SACHS LIQ ES FD A           | GOLDMAN SACHS FIN GOV 465 INSTITUT                                  | CUSIP: N/A<br>LEI: N/A                        | Long             | STIV             | RF                | US        |   1240000 | PA      | $1240000.00   | 10.36%            |  |  |  | No            |                  1 | On Loan: No      |
| Wave Life Sciences Ltd.             | WAVE LIFE SCIENCES LTD                                              | CUSIP: Y95308105<br>LEI: 54930070006GPKFYZ813 | Long             | EC               | CORP              | SG        |     15848 | NS      | $143265.92    | 1.20%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2025-12-07

**Name of Applicant:** Direxion Shares ETF Trust

**Signature:** Patrick Rudnick

**Name of Signer:** Patrick Rudnick

**Title:** Principal Executive Officer