# EDGAR Filing Document

**Accession Number:** 0001616543
**File Stem:** 0001104659-25-074746
**Filing Date:** 2025-8
**Character Count:** 29973
**Document Hash:** 316121b7c64dba1212cc1ca6588519f0
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-25-074746.hdr.sgml**: 20250806

**ACCESSION NUMBER**: 0001104659-25-074746

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 15

**FILED AS OF DATE**: 20250806

**DATE AS OF CHANGE**: 20250806

**EFFECTIVENESS DATE**: 20250806

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Senseonics Holdings, Inc.
- **CENTRAL INDEX KEY:** 0001616543
- **STANDARD INDUSTRIAL CLASSIFICATION:** INDUSTRIAL INSTRUMENTS FOR MEASUREMENT, DISPLAY, AND CONTROL [3823]
- **ORGANIZATION NAME:** 08 Industrial Applications and Services
- **EIN:** 471210911
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-289309
- **FILM NUMBER:** 251190286

**BUSINESS ADDRESS:**
- **STREET 1:** 20451 SENECA MEADOWS PARKWAY
- **CITY:** GERMANTOWN
- **STATE:** MD
- **ZIP:** 20876
- **BUSINESS PHONE:** (301) 515-7260

**MAIL ADDRESS:**
- **STREET 1:** 20451 SENECA MEADOWS PARKWAY
- **CITY:** GERMANTOWN
- **STATE:** MD
- **ZIP:** 20876

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ASN Technologies, Inc.
- **DATE OF NAME CHANGE:** 20140813

**As filed with the Securities and Exchange Commission on August 6, 2025**

**Registration No. 333-**

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**FORM S-8**

**REGISTRATION STATEMENT**

**UNDER**

**THE SECURITIES ACT OF 1933**

**Senseonics Holdings, Inc.**

(Exact name of Registrant as specified in its charter)

---

| | |
|:---|:---|
| **Delaware** | **47-1210911** |
| (State or other jurisdiction of Incorporation or<br> organization) | (I.R.S. Employer Identification No.) |

---

**20451 Seneca Meadows Parkway**

**Germantown, MD 20876-7005**

(Address of principal executive offices) (Zip code)

**Amended and Restated 2015 Equity Incentive Plan**

**2016 Employee Stock Purchase Plan**

(Full title of the plan)

**Timothy T. Goodnow**

**President and Chief Executive Officer**

**Senseonics Holdings, Inc.**

**20451 Seneca Meadows Parkway**

**Germantown, MD 20876-7005**

**(301) 515-7260**

(Name and address of agent for service) (Telephone number, including area code, of agent for service)

**Copies to:**

---

| | |
|:---|:---|
| **Darren K. DeStefano<br> Reid Hooper**<br> Cooley LLP<br> 11951 Freedom Drive<br> Reston, VA 20190<br> (703) 456-8000 | **Rick Sullivan**<br> Chief Financial Officer<br> Senseonics Holdings, Inc.<br> 20451 Seneca Meadows Parkway<br> Germantown, MD 20876-7005<br> (301) 515-7260 |

---

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

Large accelerated filer ◻ Accelerated filer ◻ <br> Non-accelerated filer ⌧ Smaller reporting company ⌧ <br> Emerging growth company ◻

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ◻

**EXPLANATORY NOTE**

This Registration Statement on Form S-8 (the "Registration Statement") is being filed for the purpose of registering an additional 86,311,952 shares of common stock of Senseonics Holdings, Inc. (the "Registrant") issuable pursuant to the Senseonics Holdings, Inc. Amended and Restated 2015 Equity Incentive Plan (the "2015 EIP") and 2016 Employee Stock Purchase Plan (the "2016 ESPP"). These additional shares of Common Stock are securities of the same class as other securities for which an original registration statement on [Form S-8 (File No. 333-210586) was filed with the Securities and Exchange Commission (the "Commission") on April 4, 2016](https://www.sec.gov/Archives/edgar/data/1616543/000110465916109617/a16-7847_1s8.htm). Accordingly, the contents of the Registrant's registration statements on Form S-8 filed with the Commission on [April 4, 2016 (File No. 333-210586)](https://www.sec.gov/Archives/edgar/data/1616543/000110465916109617/a16-7847_1s8.htm), [May 10, 2018 (File No. 333-224827)](https://www.sec.gov/Archives/edgar/data/1616543/000110465918032197/a18-13323_1s8.htm), [May 9, 2019 (File No. 333-231334)](https://www.sec.gov/Archives/edgar/data/1616543/000110465919028236/a19-9588_1s8.htm) and [May 26, 2022 (File No. 333-265241)](https://www.sec.gov/Archives/edgar/data/1616543/000110465922065312/tm2216961d2_s8.htm) are incorporated by reference into this Registration Statement pursuant to General Instruction E of Form S-8. These additional shares of common stock have become reserved for issuance as a result of the operation of the "evergreen" provision in the 2015 EIP and 2016 ESPP, which provides that the total number of shares subject to such plan may be increased each year pursuant to a specified formula.

**PART II**

**ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE**

The Registrant is subject to the informational and reporting requirements of Section 12(b) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and in accordance therewith files reports and other information with the Securities and Exchange Commission (the "Commission"). The following documents filed by the Registrant with the Commission pursuant to the Exchange Act are incorporated by reference in this Registration Statement:

&nbsp;&nbsp;&nbsp;&nbsp;(a) [The Registrant's Annual Report on Form 10-K (File No. 001-37717) for the fiscal year ended December 31, 2024, filed with the Commission on March 3, 2025;](https://www.sec.gov/ix?doc=/Archives/edgar/data/1616543/000155837025002044/sens-20241231x10k.htm)

&nbsp;&nbsp;&nbsp;&nbsp;(b) [The Registrant's Definitive Proxy Statement on Schedule 14A for the 2025 Annual Meeting of Stockholders (File No. 001-37717) filed with the Commission on April 10, 2025 <u>;</u>](https://www.sec.gov/ix?doc=/Archives/edgar/data/1616543/000110465925033545/tm252364-2_def14a.htm)

&nbsp;&nbsp;&nbsp;&nbsp;(c) The Registrant's Current Report on Form 10-Q (File No. 001-37717) for the fiscal quarters ended March 31, 2025
and June 30, 2025, filed with the Commission on [May 8, 2025](https://www.sec.gov/ix?doc=/Archives/edgar/data/0001616543/000155837025006983/sens-20250331x10q.htm) and [August 6, 2025](https://www.sec.gov/ix?doc=/Archives/edgar/data/1616543/000155837025010510/sens-20250630x10q.htm) ;

&nbsp;&nbsp;&nbsp;&nbsp;(d) The Registrant's Current Reports on Form 8-K (File No. 001-37717) filed with the Commission on [January 13, 2025](https://www.sec.gov/ix?doc=/Archives/edgar/data/1616543/000110465925002855/tm252718d1_8k.htm) , [January 17, 2025](https://www.sec.gov/ix?doc=/Archives/edgar/data/1616543/000110465925004468/tm253715d1_8k.htm) , [May 15, 2025](https://www.sec.gov/ix?doc=/Archives/edgar/data/1616543/000110465925049437/tm2514956d1_8k.htm) , [May 16, 2025](https://www.sec.gov/ix?doc=/Archives/edgar/data/1616543/000110465925050090/tm2515359d1_8k.htm) (as amended on [May 19, 2025](https://www.sec.gov/ix?doc=/Archives/edgar/data/1616543/000110465925050221/tm2515501d1_8ka.htm)) and [May 21, 2025;](https://www.sec.gov/ix?doc=/Archives/edgar/data/1616543/000110465925051602/tm2515861d1_8k.htm) and

&nbsp;&nbsp;&nbsp;&nbsp;(e) The Registrant's description of its common stock contained in its registration statement on [Form 8-A, filed with the SEC on March 11, 2016](https://www.sec.gov/Archives/edgar/data/1616543/000110465916104506/a15-15234_138a12b.htm) , as updated by [Exhibit 4.3](https://www.sec.gov/Archives/edgar/data/1616543/000155837025002044/sens-20241231xex4d3.htm) to its Annual Report on Form 10-K filed with the Commission on March 3, 2025, including any amendment or report filed for
 the purpose of updating such description.

All documents, reports and definitive proxy or information statements filed pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act after the date of this Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference into this Registration Statement and to be a part hereof from the date of filing of such documents; provided, however, that documents, reports and definitive proxy or information statements, or portions thereof, which are furnished and not filed in accordance with the rules of the Commission shall not be deemed incorporated by reference into this Registration Statement. Any statement contained in a document incorporated or deemed to be incorporated herein by reference shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes that statement. Any such statement so modified or superseded shall not constitute a part of this Registration Statement, except as so modified or superseded.

**ITEM 8. EXHIBITS**

---

| | |
|:---|:---|
| **Exhibit<br> Number** | **Description** |
| [4.1(1)](https://www.sec.gov/Archives/edgar/data/1616543/000110465916107185/a16-7127_1ex3d1.htm) | [Amended and Restated Certificate of Incorporation, as currently in effect.](https://www.sec.gov/Archives/edgar/data/1616543/000110465916107185/a16-7127_1ex3d1.htm) |
| [4.2(2)](https://www.sec.gov/Archives/edgar/data/1616543/000155837018006768/sens-20180630ex3374f9028.htm) | [Certificate of Amendment to Amended and Restated Certificate of Incorporation.](https://www.sec.gov/Archives/edgar/data/1616543/000155837018006768/sens-20180630ex3374f9028.htm) |
| [4.3(3)](https://www.sec.gov/Archives/edgar/data/1616543/000110465920118175/tm2034287d1_ex3-1.htm) | [Certificate of Amendment to Amended and Restated Certificate of Incorporation.](https://www.sec.gov/Archives/edgar/data/1616543/000110465920118175/tm2034287d1_ex3-1.htm) |
| [4.4(4)](https://www.sec.gov/Archives/edgar/data/1616543/000110465924064335/tm2415323d1_ex3-1.htm) | [Certificate of Amendment to Amended and Restated Certificate of Incorporation.](https://www.sec.gov/Archives/edgar/data/1616543/000110465924064335/tm2415323d1_ex3-1.htm) |
| [4.5(5)](https://www.sec.gov/Archives/edgar/data/1616543/000110465916107185/a16-7127_1ex3d2.htm) | [Amended and Restated Bylaws, as currently in effect.](https://www.sec.gov/Archives/edgar/data/1616543/000110465916107185/a16-7127_1ex3d2.htm) |
| [4.6(6)](https://www.sec.gov/Archives/edgar/data/1616543/000155837021002458/sens-20201231xex3d7.htm) | [Amendment to Bylaws.](https://www.sec.gov/Archives/edgar/data/1616543/000155837021002458/sens-20201231xex3d7.htm) |
| [4.7(7)](https://www.sec.gov/Archives/edgar/data/1616543/000110465920096504/tm2028874d1_ex3-1.htm) | [Certificate of Designation of Preferences, Rights and Limitations of Series A Convertible Preferred Stock.](https://www.sec.gov/Archives/edgar/data/1616543/000110465920096504/tm2028874d1_ex3-1.htm) |
| [4.8(8)](https://www.sec.gov/Archives/edgar/data/1616543/000155837022016867/sens-20220930xex3d5.htm) | [Certificate of Designation of Preferences, Rights and Limitations of Series B Convertible Preferred Stock.](https://www.sec.gov/Archives/edgar/data/1616543/000155837022016867/sens-20220930xex3d5.htm) |
| [4.9(9)](https://www.sec.gov/Archives/edgar/data/1616543/000104746916010842/a2227399zex-4_2.htm) | [Specimen stock certificate evidencing shares of Common Stock.](https://www.sec.gov/Archives/edgar/data/1616543/000104746916010842/a2227399zex-4_2.htm) |
| [4.10(10)](https://www.sec.gov/Archives/edgar/data/1616543/000110465916109617/a16-7847_1ex4d7.htm) | [Amended and Restated 2015 Equity Incentive Plan.](https://www.sec.gov/Archives/edgar/data/1616543/000110465916109617/a16-7847_1ex4d7.htm) |
| [4.11(11)](https://www.sec.gov/Archives/edgar/data/1616543/000104746915009159/a2226823zex-10_7.htm) | [Form of Stock Option Grant Notice and Stock Option Agreement under Amended and Restated 2015 Equity Incentive Plan.](https://www.sec.gov/Archives/edgar/data/1616543/000104746915009159/a2226823zex-10_7.htm) |
| [4.12(12)](https://www.sec.gov/Archives/edgar/data/1616543/000104746915009159/a2226823zex-10_8.htm) | [Form of Restricted Stock Unit Grant Notice and Restricted Stock Unit Award Agreement under Amended and Restated 2015 Equity Incentive Plan.](https://www.sec.gov/Archives/edgar/data/1616543/000104746915009159/a2226823zex-10_8.htm) |
| [4.13(13)](https://www.sec.gov/Archives/edgar/data/1616543/000110465916109617/a16-7847_1ex4d10.htm) | [2016 Employee Stock Purchase Plan.](https://www.sec.gov/Archives/edgar/data/1616543/000110465916109617/a16-7847_1ex4d10.htm) |
| [5.1](tm2522556d1_ex5-1.htm) | [Opinion of Cooley LLP.](tm2522556d1_ex5-1.htm) |
| [23.1](tm2522556d1_ex23-1.htm) | [Consent of KPMG LLP, independent registered public accounting firm.](tm2522556d1_ex23-1.htm) |
| [23.2](tm2522556d1_ex5-1.htm) | [Consent of Cooley LLP (included in Exhibit 5.1).](tm2522556d1_ex5-1.htm) |
| [24.1](#ABC2) | [Power of Attorney (included on the signature page of this Form S-8).](#ABC2) |
| [107](tm2522556d1_ex-filingfees.htm) | [Filing Fee Table.](tm2522556d1_ex-filingfees.htm) |

---

------

(1) Previously filed as Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-37717), filed with the Commission on March 23, 2016, and incorporated by reference herein.

(2) Previously filed as Exhibit 3.3 to the Registrant's Quarterly Report on Form 10-Q for the Quarter ended June 30, 2018 (File No. 001-37717), filed with the Commission on August 8, 2018, and incorporated by reference herein.

(3) Previously filed as Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-37717), filed with the Commission on October 26, 2020. , and incorporated by reference herein.

(4) Previously filed as Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-37717), filed with the Commission on May 22, 2024, and incorporated by reference herein.

(5) Previously filed as Exhibit 3.2 to the Registrant's Current Report on Form 8-K (File No. 001-37717), filed with the Commission on March 23, 2016, and incorporated by reference herein.

(6) Previously filed as Exhibit 3.7 to the Registrant's Annual Report on Form 10-K (File No. 001-37717), filed with the Commission on March 5, 2021, and incorporated by reference herein.

(7) Previously filed as Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-37717), filed with the Commission on August 18, 2020, and incorporated by reference herein.

(8) Previously filed as Exhibit 3.5 to the Registrant's Quarterly Report on Form 10-Q (File No. 001-37717), filed with the Commission on November 8, 2022, and incorporated by reference herein.

(9) Previously filed as Exhibit 4.2 to Amendment No. 2 to the Registrant's Registration Statement on Form S-1 (File No. 333-208984), filed with the Commission on March 8, 2016, and incorporated by reference herein.

(10) Previously filed as Exhibit 4.7 to the Registrant's Registration Statement on Form S-8 (File No. 333-210586), filed with the Commission on April 4, 2016, and incorporated by reference herein.

(11) Previously filed as Exhibit 10.7 to the Registrant's Current Report on Form 8-K (File No. 333-198168), filed with the Commission on December 10, 2015, and incorporated by reference herein.

(12) Previously filed as Exhibit 10.8 to the Registrant's Current Report on Form 8-K (File No. 333-198168), filed with the Commission on December 10, 2015, and incorporated by reference herein.

(13) Previously filed as Exhibit 4.10 to the Registrant's Registration Statement on Form S-8 (File No. 333-210586), filed with the Commission on April 4, 2016, and incorporated by reference herein.

**SIGNATURES**

Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Germantown, State of Maryland, on this sixth day of August 2025.

---

| | |
|:---|:---|
| **SENSEONICS HOLDINGS, INC.** | **SENSEONICS HOLDINGS, INC.** |
| By: | /s/ Timothy T. Goodnow |
|  | Timothy T. Goodnow |
|  | *President and Chief Executive Officer* |

---

**POWER OF ATTORNEY**

**Know All Persons By These Presents**, that each person whose signature appears below constitutes and appoints Timothy T. Goodnow and Rick Sullivan, and each or any one of them, his or her true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or their or his or her substitutes or substitute, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

---

| | | |
|:---|:---|:---|
| **Signature** | **Title** | **Date** |
| */s/ Timothy T. Goodnow. Ph.D.* | President, Chief Executive Officer and Director (*Principal Executive Officer*) | August 6, 2025 |
| Timothy T. Goodnow | President, Chief Executive Officer and Director (*Principal Executive Officer*) |  |
| */s/ Rick Sullivan* | Chief Financial Officer (*Principal Financial Officer and Principal Accounting Office*r) | August 6, 2025 |
| Rick Sullivan | Chief Financial Officer (*Principal Financial Officer and Principal Accounting Office*r) |  |
| */s/ Stephen P. DeFalco* | Chairman of the Board of Directors | August 6, 2025 |
| Stephen P. DeFalco |  |  |
| */s/ Steven Edelman, M.D.* | Director | August 6, 2025 |
| Steven Edelman |  |  |
| */s/ Brian Hansen* | Director | August 6, 2025 |
| Brian Hansen |  |  |
| */s/ Edward J. Fiorentino* | Director | August 6, 2025 |
| Edward J. Fiorentino |  |  |
| */s/ Francine Kaufman, M.D.* | Director and Chief Medical Officer | August 6, 2025 |
| Francine Kaufman |  |  |
| */s/ Sharon Larkin* | Director | August 6, 2025 |
| Sharon Larkin |  |  |
| */s/ Douglas S. Prince* | Director | August 6, 2025 |
| Douglas S. Prince |  |  |
| */s/ Koichiro Sato* | Director | August 6, 2025 |
| Koichiro Sato |  |  |
| */s/ Douglas A. Roeder* | Director | August 6, 2025 |
| Douglas A. Roeder |  |  |

---

## Exhibit 5.1

**Exhibit 5.1**

![](tm2522556d1_ex5-1img001.jpg)

August 6, 2025

Senseonics Holdings, Inc.

20451 Seneca Meadows Parkway

Germantown, MD 20876-7005

**Re: Senseonics Holdings, Inc. – Registration Statement on Form S-8**

Ladies and Gentlemen:

We have acted as counsel to Senseonics Holdings, Inc., a Delaware corporation (the "***Company***") in connection with the filing by the Company of a registration statement on Form S-8 (the "***Registration Statement***") with the Securities and Exchange Commission (the "***Commission***") covering the offering by the Company of up to 86,311,952 shares (the "***Shares***") of its Common Stock, par value $0.001 per share ("***Common Stock***"), consisting of (i) 67,131,518 shares of Common Stock issuable pursuant to the Company's Amended and Restated 2015 Equity Incentive Plan (the "***2015 EIP***") and (ii) 19,180,434 shares of Common Stock issuable pursuant to the Company's 2016 Employee Stock Purchase Plan (together with the 2015 EIP, the "***Plans***").

In connection with this opinion, we have examined and relied upon (a) the Registration Statement and the related prospectuses, (b) the Company's certificate of incorporation and bylaws, each as currently in effect, (c) the Plans, and (d) such other records, documents, certificates, memoranda and instruments as in our judgment are necessary or appropriate to enable us to render the opinion expressed below. We have assumed the genuineness of all signatures, the authenticity of all documents submitted to us as originals; the conformity to originals of all documents submitted to us as copies; the accuracy, completeness and authenticity of certificates of public officials; and the due authorization, execution and delivery of all documents by all persons other than the Company. As to certain factual matters, we have relied upon a certificate of an officer of the Company and have not independently verified such matters.

Our opinion is expressed only with respect to the General Corporation Law of the State of Delaware. We express no opinion to the extent that any other laws are applicable to the subject matter hereof and express no opinion and provide no assurance as to compliance with any federal or state securities law, rule or regulation.

On the basis of the foregoing, and in reliance thereon, we are of the opinion that the Shares, when issued in accordance with the Plans, the Registration Statement and the related prospectuses, will be validly issued, fully paid and nonassessable (except as to Shares issued pursuant to deferred payment arrangements, which will be fully paid and nonassessable when such deferred payments are made in full).

This opinion is limited to the matters expressly set forth in this letter, and no opinion has been or should be implied, or may be inferred, beyond the matters expressly stated. This opinion speaks only as to law and facts in effect or existing as of the date hereof, and we have no obligation or responsibility to update or supplement this letter to reflect any facts or circumstances that may hereafter come to our attention or any changes in law that may hereafter occur.

We consent to the filing of this opinion as an exhibit to the Registration Statement. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act of 1933, as amended, or the rules and regulations of the Commission thereunder.

ONE FREEDOM SQUARE, RESTON TOWN CENTER, 11951 FREEDOM DRIVE, RESTON, VA 20190-5656 T: (703) 456-8000 F: (703) 456-8100 WWW.COOLEY.COM

![](tm2522556d1_ex5-1img001.jpg)

Sincerely,

Cooley LLP

---

| | |
|:---|:---|
| By: | /s/ Darren K. DeStefano |
|  | Darren K. DeStefano |

---

ONE FREEDOM SQUARE, RESTON TOWN CENTER, 11951 FREEDOM DRIVE, RESTON, VA 20190-5656 T: (703) 456-8000 F: (703) 456-8100 WWW.COOLEY.COM

## Exhibit 23.1

**Exhibit 23.1**

**Consent of Independent Registered Public Accounting Firm**

We consent to the use of our report dated March 3, 2025, with respect to the consolidated financial statements of Senseonics Holdings, Inc. and subsidiaries, incorporated herein by reference.

The audit report covering the December 31, 2024 consolidated financial statements contains an explanatory paragraph that states that the Company's current operating plan, existing unrestricted cash and cash equivalents, and minimum cash and satisfaction of performance milestones to comply with debt covenants under its Loan and Security Agreement raise substantial doubt about its ability to continue as a going concern for the one-year period following the date the consolidated financial statements are issued. The consolidated financial statements do not include any adjustments that might result from the outcome of that uncertainty.

/s/ KPMG LLP

Baltimore, Maryland

August 6, 2025

## Ex-Filing

?xml version='1.0' encoding='ASCII'? EX-FILING FEES

---

| |
|:---|
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Calculation of Filing Fee Tables**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **S-8**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Senseonics Holdings, Inc.**  |

---

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| | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Security Type**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Security Class Title**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Fee Calculation Rule**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Amount Registered**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Proposed Maximum Offering Price Per Unit**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Maximum Aggregate Offering Price**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Fee Rate**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Amount of Registration Fee**  |
| 1 | Equity | Common Stock, $0.001 par value per share, Senseonics Holdings, Inc. 2015 Equity Incentive Plan | 457(a) | 67131518 | $0.4791 | $32162710.27 | 0.0001531 | $4924.11 |
| 2 | Equity | Common Stock, $0.001 par value per share, Senseonics Holdings, Inc. 2016 Employee Stock Purchase Plan | 457(a) | 19180434 | $0.4791 | $9189345.93 | 0.0001531 | $1406.89 |
| Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: |  | $41352056.20  |  | $6331.00  |
| Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  |  |  |  | $0.00  |
| Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  |  |  |  | $6331.00  |

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Offering Note** <br>

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <sup>1</sup> (1) Pursuant to Rule 416(a) of the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement shall also cover any additional shares of the Registrant's common stock, par value $0.001 per share ("Common Stock") that become issuable in respect of the securities identified in the above table by reason of any stock dividend, stock split, recapitalization or other similar transaction. (2) Represents shares of Common Stock that were added to the shares authorized for issuance under the Senseonics Holdings, Inc. 2015 Equity Incentive Plan (the "2015 EIP") on January 1, 2020, January 1, 2021, January 1, 2023, January 1, 2024 and January 1, 2025 pursuant to an "evergreen" provision contained in the 2015 EIP. (3) Estimated in accordance with Rule 457(c) and (h) under the Securities Act solely for the purpose of calculating the registration fee. The proposed maximum offering price per share and the proposed maximum aggregate offering price are calculated using the average of the high and low prices of the Registrant's Common Stock as reported on the NYSE American on August 1, 2025. (4) The Registrant does not have any fee offsets.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <sup>2</sup> (1) See 1 (1) and (3)-(4). (2) Represents shares of Common Stock that were added to the shares authorized for issuance under the Senseonics Holdings, Inc. 2016 Employee Stock Purchase Plan (the "2016 ESPP") on January 1, 2020, January 1, 2021, January 1, 2023, January 1, 2024 and January 1, 2025 pursuant to an "evergreen" provision contained in the 2016 ESPP.

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|:---|:---|
| | |
| **Rule 457(p)** | **Rule 457(p)** |
| Fee Offset Claims | N/A |
| Fee Offset Sources | N/A |

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