# EDGAR Filing Document

**Accession Number:** 0001053906
**File Stem:** 0001053906-23-000002
**Filing Date:** 2023-2
**Character Count:** 18002
**Document Hash:** 6bbfaf2c4f4a8f8e3c28cba3006c1abd
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001053906-23-000002.hdr.sgml**: 20230213

**ACCESSION NUMBER**: 0001053906-23-000002

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230213

**DATE AS OF CHANGE**: 20230213

**EFFECTIVENESS DATE**: 20230213

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Artal Group S.A.
- **CENTRAL INDEX KEY:** 0001053906
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** N4

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-15027
- **FILM NUMBER:** 23615023

**BUSINESS ADDRESS:**
- **STREET 1:** VALLEY PARK
- **STREET 2:** 44, RUE DE LA VALLEE
- **CITY:** LUXEMBOURG
- **STATE:** N4
- **ZIP:** L-2661
- **BUSINESS PHONE:** (352) 22.42.59-1

**MAIL ADDRESS:**
- **STREET 1:** VALLEY PARK
- **STREET 2:** 44, RUE DE LA VALLEE
- **CITY:** LUXEMBOURG
- **STATE:** N4
- **ZIP:** L-2661

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ARTAL GROUP S A
- **DATE OF NAME CHANGE:** 19980128

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2022

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** Artal Group S.A.<br>**Address:** VALLEY PARK<br>44 RUE DE LA VALLEE<br>LUXEMBOURG, N4 L-2661

**Form 13F File Number:** 028-15027

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Anne Goffard<br>**Title:** Authorized Person<br>**Phone:** 352224259-1

**Signature, Place, and Date of Signing:**

/s/ Anne Goffard  Luxembourg, N4  02-13-2023<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 6

**Form 13F Information Table Entry Total:** 131

**Form 13F Information Table Value Total:** $1791614

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

| No.   | Name                                   | Form 13F File Number   |
|:---|:---|:---|
|  | Stichting Administratiekantoor Westend | 028-15028              |
|  | Westend S.A.                           | 028-15029              |
|  | Artal International Management S.A.    | 028-15031              |
|  | Artal International S.C.A.             | 028-15033              |
|  | Invus Public Equities Advisors LLC     | 028-11522              |
|  | Artal Luxembourg S. A.                 | 028-19506              |

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| 23ANDME HOLDING CO | CLASS A COM | 90138Q108 |  | 1428 | 661009 | SH |  | DFND | 123456 | 661009 | 0 | 0 |
| 89BIO INC | COM | 282559103 |  | 5092 | 400000 | SH |  | DFND | 123456 | 400000 | 0 | 0 |
| AC IMMUNE SA | SHS | H00263105 |  | 2040 | 1000000 | SH |  | DFND | 123456 | 1000000 | 0 | 0 |
| ACHILLES THERAPEUTICS PLC | SPONSORED ADS | 00449L102 |  | 2030 | 2255375 | SH |  | DFND | 123456 | 2255375 | 0 | 0 |
| ADAGENE INC | ADS | 005329107 |  | 1325 | 1000000 | SH |  | DFND | 123456 | 1000000 | 0 | 0 |
| AGENUS INC | COM NEW | 00847G705 |  | 34800 | 14500000 | SH |  | DFND | 123456 | 14500000 | 0 | 0 |
| ALLOVIR INC | COM | 019818103 |  | 28611 | 5577167 | SH |  | DFND | 123456 | 5577167 | 0 | 0 |
| ALPINE IMMUNE SCIENCES INC | COM | 02083G100 |  | 8769 | 1193030 | SH |  | DFND | 123456 | 1193030 | 0 | 0 |
| ALX ONCOLOGY HLDGS INC | COM | 00166B105 |  | 5635 | 500000 | SH |  | DFND | 123456 | 500000 | 0 | 0 |
| AMBRX BIOPHARMA INC | SPONSORED ADS | 02290A102 |  | 4886 | 2152291 | SH |  | DFND | 123456 | 2152291 | 0 | 0 |
| AMICUS THERAPEUTICS INC | COM | 03152W109 |  | 48840 | 4000000 | SH |  | DFND | 123456 | 4000000 | 0 | 0 |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 |  | 46539 | 900000 | SH |  | DFND | 123456 | 900000 | 0 | 0 |
| APPLIED THERAPEUTICS INC | COM | 03828A101 |  | 304 | 400000 | SH |  | DFND | 123456 | 400000 | 0 | 0 |
| APTINYX INC | COM | 03836N103 |  | 1745 | 6116493 | SH |  | DFND | 123456 | 6116493 | 0 | 0 |
| ARAVIVE INC | COM | 03890D108 |  | 6036 | 4572515 | SH |  | DFND | 123456 | 4572515 | 0 | 0 |
| AURA BIOSCIENCES INC | COM | 05153U107 |  | 4305 | 410000 | SH |  | DFND | 123456 | 410000 | 0 | 0 |
| AURINIA PHARMACEUTICALS INC | COM | 05156V102 |  | 4320 | 1000000 | SH |  | DFND | 123456 | 1000000 | 0 | 0 |
| AVIDITY BIOSCIENCES INC | COM | 05370A108 |  | 11095 | 500000 | SH |  | DFND | 123456 | 500000 | 0 | 0 |
| BEIGENE LTD | SPONSORED ADR | 07725L102 |  | 131964 | 600000 | SH |  | DFND | 123456 | 600000 | 0 | 0 |
| BEIGENE LTD | SPONSORED ADR | 07725L102 |  | 21994 | 100000 | SH | Call | DFND | 123456 | 100000 | 0 | 0 |
| BELLUS HEALTH INC NEW | COM NEW | 07987C204 |  | 30414 | 3700000 | SH |  | DFND | 123456 | 3700000 | 0 | 0 |
| BIOHAVEN LTD | COM | G1110E107 |  | 6940 | 500000 | SH |  | DFND | 123456 | 500000 | 0 | 0 |
| BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 |  | 2964 | 1646517 | SH |  | DFND | 123456 | 1646517 | 0 | 0 |
| BRIDGEBIO PHARMA INC | COM | 10806X102 |  | 1905 | 250000 | SH |  | DFND | 123456 | 250000 | 0 | 0 |
| CARDIFF ONCOLOGY INC | COM | 14147L108 |  | 1050 | 750000 | SH |  | DFND | 123456 | 750000 | 0 | 0 |
| CARIBOU BIOSCIENCES INC | COM | 142038108 |  | 662 | 105347 | SH |  | DFND | 123456 | 105347 | 0 | 0 |
| CEREVEL THERAPEUTICS HLDNG I | COM | 15678U128 |  | 59926 | 1900000 | SH |  | DFND | 123456 | 1900000 | 0 | 0 |
| CIDARA THERAPEUTICS INC | COM | 171757107 |  | 170 | 224675 | SH |  | DFND | 123456 | 224675 | 0 | 0 |
| CODIAK BIOSCIENCES INC | COM | 192010106 |  | 80 | 200000 | SH |  | DFND | 123456 | 200000 | 0 | 0 |
| CONTRAFECT CORP | COM NEW | 212326300 |  | 144 | 1500000 | SH |  | DFND | 123456 | 1500000 | 0 | 0 |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 |  | 425 | 500000 | SH |  | DFND | 123456 | 500000 | 0 | 0 |
| CULLINAN ONCOLOGY INC | COM | 230031106 |  | 2638 | 250000 | SH |  | DFND | 123456 | 250000 | 0 | 0 |
| CURIS INC | COM NEW | 231269200 |  | 715 | 1300000 | SH |  | DFND | 123456 | 1300000 | 0 | 0 |
| CYCLERION THERAPEUTICS INC | COM | 23255M105 |  | 1816 | 2768069 | SH |  | DFND | 123456 | 2768069 | 0 | 0 |
| CYCLERION THERAPEUTICS INC | COM | 23255M105 |  | 7 | 11053 | SH |  | DFND | 1234 | 11053 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 45820 | 1000000 | SH |  | DFND | 123456 | 1000000 | 0 | 0 |
| DENALI THERAPEUTICS INC | COM | 24823R105 |  | 22248 | 800000 | SH |  | DFND | 123456 | 800000 | 0 | 0 |
| DYNE THERAPEUTICS INC | COM | 26818M108 |  | 6085 | 525000 | SH |  | DFND | 123456 | 525000 | 0 | 0 |
| EQRX INC | COM | 26886C107 |  | 4920 | 2000000 | SH |  | DFND | 123456 | 2000000 | 0 | 0 |
| ERASCA INC | COM | 29479A108 |  | 20303 | 4710682 | SH |  | DFND | 123456 | 4710682 | 0 | 0 |
| EVOTEC AG | SPONSORED ADS | 30050E105 |  | 9299 | 1149425 | SH |  | DFND | 123456 | 1149425 | 0 | 0 |
| EXSCIENTIA PLC | ADS | 30223G102 |  | 2932 | 550000 | SH |  | DFND | 123456 | 550000 | 0 | 0 |
| FATE THERAPEUTICS INC | COM | 31189P102 |  | 26234 | 2600000 | SH |  | DFND | 123456 | 2600000 | 0 | 0 |
| FOGHORN THERAPEUTICS INC | COM | 344174107 |  | 10978 | 1720720 | SH |  | DFND | 123456 | 1720720 | 0 | 0 |
| FUSION PHARMACEUTICALS INC | COM | 36118A100 |  | 2363 | 750000 | SH |  | DFND | 123456 | 750000 | 0 | 0 |
| GENERATION BIO CO | COM | 37148K100 |  | 11060 | 2814191 | SH |  | DFND | 123456 | 2814191 | 0 | 0 |
| GOSSAMER BIO INC | COM | 38341P102 |  | 7045 | 3246624 | SH |  | DFND | 123456 | 3246624 | 0 | 0 |
| GRAPHITE BIO INC | COM | 38870X104 |  | 2324 | 700000 | SH |  | DFND | 123456 | 700000 | 0 | 0 |
| GRITSTONE BIO INC | COM | 39868T105 |  | 6404 | 1856194 | SH |  | DFND | 123456 | 1856194 | 0 | 0 |
| HARPOON THERAPEUTICS INC | COM | 41358P106 |  | 726 | 1000000 | SH |  | DFND | 123456 | 1000000 | 0 | 0 |
| HIPPO HLDGS INC | COM NEW | 433539202 |  | 326 | 24000 | SH |  | DFND | 123456 | 24000 | 0 | 0 |
| HOOKIPA PHARMA INC | COM | 43906K100 |  | 1498 | 1849616 | SH |  | DFND | 123456 | 1849616 | 0 | 0 |
| I MAB | SPONSORED ADS | 44975P103 |  | 3553 | 850000 | SH |  | DFND | 123456 | 850000 | 0 | 0 |
| IGM BIOSCIENCES INC | COM | 449585108 |  | 41675 | 2450000 | SH |  | DFND | 123456 | 2450000 | 0 | 0 |
| IGM BIOSCIENCES INC | COM | 449585108 |  | 851 | 50000 | SH | Call | DFND | 123456 | 50000 | 0 | 0 |
| IKENA ONCOLOGY INC | COM | 45175G108 |  | 4122 | 1549513 | SH |  | DFND | 123456 | 1549513 | 0 | 0 |
| IMMUNIC INC | COM | 4525EP101 |  | 1785 | 1274713 | SH |  | DFND | 123456 | 1274713 | 0 | 0 |
| IMMUTEP LTD | SPONSORED ADS | 45257L108 |  | 1750 | 1000000 | SH |  | DFND | 123456 | 1000000 | 0 | 0 |
| INSMED INC | COM PAR $0.01 | 457669307 |  | 9990 | 500000 | SH |  | DFND | 123456 | 500000 | 0 | 0 |
| INSTIL BIO INC | COM | 45783C101 |  | 284 | 450000 | SH |  | DFND | 123456 | 450000 | 0 | 0 |
| INTELLIA THERAPEUTICS INC | COM | 45826J105 |  | 9595 | 275000 | SH |  | DFND | 123456 | 275000 | 0 | 0 |
| IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 |  | 1369 | 110532 | SH |  | DFND | 1234 | 110532 | 0 | 0 |
| ITEOS THERAPEUTICS INC | COM | 46565G104 |  | 7812 | 400000 | SH |  | DFND | 123456 | 400000 | 0 | 0 |
| IVERIC BIO INC | COM | 46583P102 |  | 21410 | 1000000 | SH |  | DFND | 123456 | 1000000 | 0 | 0 |
| KARUNA THERAPEUTICS INC | COM | 48576A100 |  | 29475 | 150000 | SH |  | DFND | 123456 | 150000 | 0 | 0 |
| KE HLDGS INC | SPONSORED ADS | 482497104 |  | 6980 | 500000 | SH |  | DFND | 123456 | 500000 | 0 | 0 |
| KE HLDGS INC | SPONSORED ADS | 482497104 |  | 11168 | 800000 | SH | Call | DFND | 123456 | 800000 | 0 | 0 |
| KINETA INC | COM | 49461C102 |  | 197 | 31055 | SH |  | DFND | 123456 | 31055 | 0 | 0 |
| KINNATE BIOPHARMA INC | COM | 49705R105 |  | 763 | 125000 | SH |  | DFND | 123456 | 125000 | 0 | 0 |
| KRONOS BIO INC | COM | 50107A104 |  | 2500 | 1542954 | SH |  | DFND | 123456 | 1542954 | 0 | 0 |
| KRYSTAL BIOTECH INC | COM | 501147102 |  | 31688 | 400000 | SH |  | DFND | 123456 | 400000 | 0 | 0 |
| KURA ONCOLOGY INC | COM | 50127T109 |  | 21097 | 1700000 | SH |  | DFND | 123456 | 1700000 | 0 | 0 |
| KYMERA THERAPEUTICS INC | COM | 501575104 |  | 49920 | 2000000 | SH |  | DFND | 123456 | 2000000 | 0 | 0 |
| LAVA THERAPEUTICS NV | SHS | N51517105 |  | 700 | 200000 | SH |  | DFND | 123456 | 200000 | 0 | 0 |
| LEAP THERAPEUTICS INC | COM | 52187K101 |  | 1800 | 4000000 | SH |  | DFND | 123456 | 4000000 | 0 | 0 |
| LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 |  | 6716 | 3516214 | SH |  | DFND | 123456 | 3516214 | 0 | 0 |
| LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 |  | 164760 | 86262020 | SH |  | DFND | 1234 | 67662150 | 0 | 0 |
| LYELL IMMUNOPHARMA INC | COM | 55083R104 |  | 2429 | 700000 | SH |  | DFND | 123456 | 700000 | 0 | 0 |
| MEI PHARMA INC | COM NEW | 55279B202 |  | 244 | 1000000 | SH |  | DFND | 123456 | 1000000 | 0 | 0 |
| MEREO BIOPHARMA GROUP PLC | SPONSORED ADS | 589492107 |  | 1125 | 1500000 | SH |  | DFND | 123456 | 1500000 | 0 | 0 |
| MERSANA THERAPEUTICS INC | COM | 59045L106 |  | 12892 | 2200000 | SH |  | DFND | 123456 | 2200000 | 0 | 0 |
| METACRINE INC | COM | 59101E103 |  | 414 | 924898 | SH |  | DFND | 123456 | 924898 | 0 | 0 |
| MINK THERAPEUTICS INC | COM | 603693102 |  | 756 | 289588 | SH |  | DFND | 123456 | 289588 | 0 | 0 |
| MIRATI THERAPEUTICS INC | COM | 60468T105 |  | 83042 | 1832758 | SH |  | DFND | 123456 | 1832758 | 0 | 0 |
| MIRATI THERAPEUTICS INC | COM | 60468T105 |  | 22655 | 500000 | SH | Call | DFND | 123456 | 500000 | 0 | 0 |
| MIRION TECHNOLOGIES INC | COM CL A | 60471A101 |  | 3305 | 500000 | SH |  | DFND | 123456 | 500000 | 0 | 0 |
| MORPHIC HLDG INC | COM | 61775R105 |  | 57513 | 2150000 | SH |  | DFND | 123456 | 2150000 | 0 | 0 |
| NANOBIOTIX | SPONSORED ADS | 63009J107 |  | 3670 | 1000000 | SH |  | DFND | 123456 | 1000000 | 0 | 0 |
| NATERA INC | COM | 632307104 |  | 8034 | 200000 | SH |  | DFND | 123456 | 200000 | 0 | 0 |
| NEXIMMUNE INC | COM | 65344D109 |  | 292 | 1200000 | SH |  | DFND | 123456 | 1200000 | 0 | 0 |
| OATLY GROUP AB | SPONSORED ADS | 67421J108 |  | 2610 | 1500000 | SH |  | DFND | 123456 | 1500000 | 0 | 0 |
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 |  | 638 | 260500 | SH |  | DFND | 123456 | 260500 | 0 | 0 |
| OMEGA THERAPEUTICS INC | COM | 68217N105 |  | 12982 | 2273530 | SH |  | DFND | 123456 | 2273530 | 0 | 0 |
| ORCHARD THERAPEUTICS PLC | SPONSORED ADS | 68570P101 |  | 669 | 1803858 | SH |  | DFND | 123456 | 1803858 | 0 | 0 |
| ORIC PHARMACEUTICALS INC | COM | 68622P109 |  | 2356 | 400000 | SH |  | DFND | 123456 | 400000 | 0 | 0 |
| OVID THERAPEUTICS INC | COM | 690469101 |  | 4650 | 2500000 | SH |  | DFND | 123456 | 2500000 | 0 | 0 |
| PALO ALTO NETWORKS INC | COM | 697435105 |  | 279 | 2000 | SH |  | DFND | 123456 | 2000 | 0 | 0 |
| PORTAGE FINTECH ACQUISITN CO | CLASS A ORD SHS | G7185D106 |  | 3819 | 380000 | SH |  | DFND | 123456 | 380000 | 0 | 0 |
| PRAXIS PRECISION MEDICINES I | COM | 74006W108 |  | 2856 | 1200000 | SH |  | DFND | 123456 | 1200000 | 0 | 0 |
| RECURSION PHARMACEUTICALS IN | CL A | 75629V104 |  | 7403 | 960204 | SH |  | DFND | 123456 | 960204 | 0 | 0 |
| RELAY THERAPEUTICS INC | COM | 75943R102 |  | 21733 | 1454716 | SH |  | DFND | 123456 | 1454716 | 0 | 0 |
| REPARE THERAPEUTICS INC | COM | 760273102 |  | 10297 | 700000 | SH |  | DFND | 123456 | 700000 | 0 | 0 |
| REPLIMUNE GROUP INC | COM | 76029N106 |  | 19040 | 700000 | SH |  | DFND | 123456 | 700000 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 23820 | 1000000 | SH |  | DFND | 123456 | 1000000 | 0 | 0 |
| RUBIUS THERAPEUTICS INC | COM | 78116T103 |  | 357 | 2042666 | SH |  | DFND | 123456 | 2042666 | 0 | 0 |
| SAGE THERAPEUTICS INC | COM | 78667J108 |  | 28605 | 750000 | SH |  | DFND | 123456 | 750000 | 0 | 0 |
| SANA BIOTECHNOLOGY INC | COM | 799566104 |  | 1580 | 400000 | SH |  | DFND | 123456 | 400000 | 0 | 0 |
| SCHOLAR ROCK HLDG CORP | COM | 80706P103 |  | 81271 | 8980270 | SH |  | DFND | 123456 | 8980270 | 0 | 0 |
| SCHRODINGER INC | COM | 80810D103 |  | 13083 | 700000 | SH |  | DFND | 123456 | 700000 | 0 | 0 |
| SEA LTD | SPONSORED ADS | 81141R100 |  | 8975 | 172500 | SH |  | DFND | 123456 | 172500 | 0 | 0 |
| SEER INC | COM CL A | 81578P106 |  | 27550 | 4750000 | SH |  | DFND | 123456 | 4750000 | 0 | 0 |
| SELECTA BIOSCIENCES INC | COM | 816212104 |  | 5518 | 4883200 | SH |  | DFND | 123456 | 4883200 | 0 | 0 |
| SENTI BIOSCIENCES INC | COM | 81726A100 |  | 78 | 55555 | SH |  | DFND | 123456 | 55555 | 0 | 0 |
| SOLID BIOSCIENCES INC | COM NEW | 83422E204 |  | 4892 | 909219 | SH |  | DFND | 123456 | 909219 | 0 | 0 |
| SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 |  | 52020 | 2000000 | SH |  | DFND | 123456 | 2000000 | 0 | 0 |
| SQZ BIOTECHNOLOGIES CO | COM | 78472W104 |  | 1189 | 1606309 | SH |  | DFND | 123456 | 1606309 | 0 | 0 |
| STOKE THERAPEUTICS INC | COM | 86150R107 |  | 2308 | 250000 | SH |  | DFND | 123456 | 250000 | 0 | 0 |
| SYROS PHARMACEUTICALS INC | COM NEW | 87184Q206 |  | 5255 | 1463829 | SH |  | DFND | 123456 | 1463829 | 0 | 0 |
| TALARIS THERAPEUTICS INC | COM | 87410C104 |  | 2106 | 2064262 | SH |  | DFND | 123456 | 2064262 | 0 | 0 |
| TAYSHA GENE THERAPIES INC | COM SHS | 877619106 |  | 3256 | 1440882 | SH |  | DFND | 123456 | 1440882 | 0 | 0 |
| TCR2 THERAPEUTICS INC | COM | 87808K106 |  | 749 | 750000 | SH |  | DFND | 123456 | 750000 | 0 | 0 |
| TESLA INC | COM | 88160R101 |  | 776 | 6300 | SH |  | DFND | 123456 | 6300 | 0 | 0 |
| TRAVERE THERAPEUTICS INC | COM | 89422G107 |  | 10515 | 500000 | SH |  | DFND | 123456 | 500000 | 0 | 0 |
| VERVE THERAPEUTICS INC | COM | 92539P101 |  | 5805 | 300000 | SH |  | DFND | 123456 | 300000 | 0 | 0 |
| VIGIL NEUROSCIENCE INC | COM | 92673K108 |  | 28042 | 2243352 | SH |  | DFND | 123456 | 2243352 | 0 | 0 |
| VOR BIOPHARMA INC | COM | 929033108 |  | 19123 | 2875581 | SH |  | DFND | 123456 | 2875581 | 0 | 0 |
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 |  | 21000 | 3000000 | SH |  | DFND | 123456 | 3000000 | 0 | 0 |
| WW INTL INC | COM | 98262P101 |  | 57199 | 14818300 | SH |  | DFND | 12346 | 14818300 | 0 | 0 |
| XILIO THERAPEUTICS INC | COM | 98422T100 |  | 1211 | 450000 | SH |  | DFND | 123456 | 450000 | 0 | 0 |
| Y-MABS THERAPEUTICS INC | COM | 984241109 |  | 1952 | 400000 | SH |  | DFND | 123456 | 400000 | 0 | 0 |
| ZYMEWORKS INC | COM | 98985W102 |  | 3537 | 450000 | SH |  | DFND | 123456 | 450000 | 0 | 0 |

---