# EDGAR Filing Document

**Accession Number:** 0001430306
**File Stem:** 0001999371-25-012583
**Filing Date:** 2025-9
**Character Count:** 19122
**Document Hash:** 7097873b714cfaf25f0b85da136de68e
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001999371-25-012583.hdr.sgml**: 20250904

**ACCESSION NUMBER**: 0001999371-25-012583

**CONFORMED SUBMISSION TYPE**: S-3/A

**PUBLIC DOCUMENT COUNT**: 2

**FILED AS OF DATE**: 20250904

**DATE AS OF CHANGE**: 20250904

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Tonix Pharmaceuticals Holding Corp.
- **CENTRAL INDEX KEY:** 0001430306
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 261434750
- **STATE OF INCORPORATION:** NV
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-3/A
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-287965
- **FILM NUMBER:** 251293672

**BUSINESS ADDRESS:**
- **STREET 1:** 26 MAIN STREET, SUITE 101
- **CITY:** CHATHAM
- **STATE:** NJ
- **ZIP:** 07928
- **BUSINESS PHONE:** 212-980-9155

**MAIL ADDRESS:**
- **STREET 1:** 26 MAIN STREET, SUITE 101
- **CITY:** CHATHAM
- **STATE:** NJ
- **ZIP:** 07928

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** TAMANDARE EXPLORATIONS INC.
- **DATE OF NAME CHANGE:** 20080320

As filed with the Securities and Exchange Commission on September 4, 2025

Registration No. 333-287965

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**WASHINGTON, D.C. 20549**

**FORM S-3**

**(Amendment No. 1)**

**REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933**

**TONIX PHARMACEUTICALS HOLDING CORP.**

(Exact name of registrant as specified in

its charter)

---

| | |
|:---|:---|
| **Nevada** | **26-1434750** |
| (State or other jurisdiction of incorporation or organization) | (I.R.S. Employer Identification No.) |

---

**26 Main Street, Suite 101**

**Chatham, New Jersey 07928**

**(862) 904-8182**

(Address, including zip code, and telephone number, including area code, of registrant's principal executive offices)

**Seth Lederman**

**Chief Executive Officer**

**Tonix Pharmaceuticals Holding Corp.**

**26 Main Street, Suite 101**

**Chatham, New Jersey 07928** 

**(862) 904-8182**

(Name, address, including zip code, and telephone number, including area code, of agent for service)

With copies to:

**Michael J. Lerner, Esq.**

**Steven M. Skolnick, Esq.**

**Lowenstein Sandler LLP**

**One Lowenstein Drive**

**Roseland, New Jersey 07068**

**(973) 597-6394**

**APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC:** From time to time after the effective date of this registration statement.

If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box. ☐

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box. ☒

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐

If this Form is a registration statement pursuant to General Instruction I.D. or a post-effective amendment thereto that shall become effective upon filing with the Commission pursuant to Rule 462(e) under the Securities Act, check the following box. ☐

If this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.D. filed to register additional securities or additional classes of securities pursuant to Rule 413(b) under the Securities Act, check the following box. ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act:

Large accelerated filer ☐ Accelerated filer ☐ <br> Non-accelerated filer ☒ Smaller reporting company ☒ <br> Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

**The registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the registrant shall file a further amendment which specifically states that this registration statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933 or until the registration statement shall become effective on such date as the Securities and Exchange Commission, acting pursuant to said Section 8(a), may determine.**

**EXPLANATORY NOTE**

Tonix Pharmaceuticals Holding Corp. (the "Company") is filing this Amendment No. 1 (this "Amendment") to its Registration Statement on Form S-3 (File No. 333-287965) (the "Registration Statement") as an exhibits only filing to re-file Exhibit 23.1 previously filed with the Registration Statement. Accordingly, this Amendment consists only of the facing page, this explanatory note, Item 16 of Part II of the Registration Statement, the signature pages to the Registration Statement, the exhibits index and the re-filed Exhibit 23.1. This Amendment does not modify any provision of the prospectus that forms a part of the Registration Statement. Accordingly, a preliminary prospectus has been omitted.

**ITEM 16. EXHIBITS**

1.01 Form
 of Underwriting Agreement\*

---

| | |
|:---|:---|
| [3.01](http://www.sec.gov/Archives/edgar/data/1430306/000116552708000188/ex3-1.txt) | [Articles of Incorporation, filed as an exhibit to the Registration Statement on Form S-1, filed with the Commission on April 9, 2008, and incorporated herein by reference.](http://www.sec.gov/Archives/edgar/data/1430306/000116552708000188/ex3-1.txt) |

---

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| | |
|:---|:---|
| [3.02](http://www.sec.gov/Archives/edgar/data/1430306/000101376211002735/ex31.pdf) | [Articles of Merger between Tamandare Explorations Inc. and Tonix Pharmaceuticals Holding Corp., effective October 11, 2011, filed as an exhibit to the Current Report on Form 8-K, filed with the Commission on October 17, 2011, and incorporated herein by reference.](http://www.sec.gov/Archives/edgar/data/1430306/000101376211002735/ex31.pdf) |

---

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| | |
|:---|:---|
| [3.03](http://www.sec.gov/Archives/edgar/data/1430306/000114420416106631/v441599_ex3-01.htm) | [Third Amended and Restated Bylaws, filed as an exhibit to the Current Report on Form 8-K, filed with the Commission on June 3, 2016 and incorporated herein by reference.](http://www.sec.gov/Archives/edgar/data/1430306/000114420416106631/v441599_ex3-01.htm) |

---

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| | |
|:---|:---|
| [3.04](http://www.sec.gov/Archives/edgar/data/1430306/000161577417001073/s105580_ex3-1.htm) | [Certificate of Change of Tonix Pharmaceuticals Holding Corp., dated March 13, 2017 and effective March 17, 2017, filed as an exhibit to the Current Report on Form 8-K, filed with the Commission on March 16, 2017, and incorporated herein by reference.](http://www.sec.gov/Archives/edgar/data/1430306/000161577417001073/s105580_ex3-1.htm) |

---

---

| | |
|:---|:---|
| [3.05](http://www.sec.gov/Archives/edgar/data/1430306/000161577417003222/s106582_ex3-1.htm) | [Certificate of Amendment to Articles of Incorporation, effective June 16, 2017, filed as an exhibit to the Current Report on Form 8-K, filed with the Commission on June 16, 2017, and incorporated herein by reference.](http://www.sec.gov/Archives/edgar/data/1430306/000161577417003222/s106582_ex3-1.htm) |

---

---

| | |
|:---|:---|
| [3.06](http://www.sec.gov/Archives/edgar/data/1430306/000138713119008088/ex3-01.htm) | [Certificate of Amendment to Tonix Pharmaceuticals Holding Corp.'s Articles of Incorporation, as amended, effective May 3, 2019, filed as an exhibit to the Current Report on Form 8-K, filed with the Commission on May 8, 2019, and incorporated herein by reference.](http://www.sec.gov/Archives/edgar/data/1430306/000138713119008088/ex3-01.htm) |

---

---

| | |
|:---|:---|
| [3.07](http://www.sec.gov/Archives/edgar/data/1430306/000138713119008088/ex3-01.htm) | [Certificate of Amendment to Tonix Pharmaceuticals Holding Corp.'s Articles of Incorporation, as amended, effective October 31, 2019, filed as an exhibit to the Current Report on Form 8-K, filed with the Commission on May 8, 2019, and incorporated herein by reference.](http://www.sec.gov/Archives/edgar/data/1430306/000138713119008088/ex3-01.htm) |

---

---

| | |
|:---|:---|
| [3.08](http://www.sec.gov/Archives/edgar/data/1430306/000138713119008088/ex3-01.htm) | [Certificate of Change of Tonix Pharmaceuticals Holding Corp.'s Articles of Incorporation, as amended, effective November 1, 2019, filed as an exhibit to the Current Report on Form 8-K, filed with the Commission on October 31, 2019, and incorporated herein by reference.](http://www.sec.gov/Archives/edgar/data/1430306/000138713119008088/ex3-01.htm) |

---

---

| | |
|:---|:---|
| [3.09](http://www.sec.gov/Archives/edgar/data/1430306/000138713120000309/ex3-01.htm) | [Certificate of Amendment to Tonix Pharmaceuticals Holding Corp.'s Articles of Incorporation, as amended, effective January 16, 2020, filed as an exhibit to the Current Report on Form 8-K, filed with the Commission on January 16, 2020, and incorporated herein by reference.](http://www.sec.gov/Archives/edgar/data/1430306/000138713120000309/ex3-01.htm) |

---

---

| | |
|:---|:---|
| [3.10](http://www.sec.gov/Archives/edgar/data/1430306/000138713120008104/ex3-01.htm) | [Certificate of Amendment to Tonix Pharmaceuticals Holding Corp.'s Articles of Incorporation, as amended, effective August 31, 2020, filed as an exhibit to the Current Report on Form 8-K, filed with the Commission on August 31, 2020, and incorporated herein by reference.](http://www.sec.gov/Archives/edgar/data/1430306/000138713120008104/ex3-01.htm) |

---

---

| | |
|:---|:---|
| [3.11](http://www.sec.gov/Archives/edgar/data/1430306/000138713121003922/ex3-01.htm) | [Certificate of Amendment to Tonix Pharmaceuticals Holding Corp.'s Articles of Incorporation, as amended, effective March 26, 2021, filed as an exhibit to the Current Report on Form 8-K, filed with the Commission on March 26, 2021, and incorporated herein by reference.](http://www.sec.gov/Archives/edgar/data/1430306/000138713121003922/ex3-01.htm) |

---

---

| | |
|:---|:---|
| [3.12](http://www.sec.gov/Archives/edgar/data/1430306/000138713122001562/ex3-01.htm) | [Certificate of Amendment to Tonix Pharmaceuticals Holding Corp.'s Articles of Incorporation, as amended, effective February 10, 2022, filed as an exhibit to the Current Report on Form 8-K, filed with the Commission on February 10, 2022, and incorporated herein by reference.](http://www.sec.gov/Archives/edgar/data/1430306/000138713122001562/ex3-01.htm) |

---

---

| | |
|:---|:---|
| [3.13](http://www.sec.gov/Archives/edgar/data/1430306/000138713122006187/ex3-01.htm) | [Certificate of Change of Tonix Pharmaceuticals Holding Corp.'s Articles of Incorporation, filed as an exhibit to the Current Report on Form 8-K, filed with the Commission on May 16, 2022, and incorporated herein by reference.](http://www.sec.gov/Archives/edgar/data/1430306/000138713122006187/ex3-01.htm) |

---

---

| | |
|:---|:---|
| [3.14](http://www.sec.gov/Archives/edgar/data/1430306/000138713122008450/ex3-01.htm) | [Certificate of Amendment to Tonix Pharmaceuticals Holding Corp.'s Articles of Incorporation, as amended, effective August 5, 2022, filed as an exhibit to the Current Report on Form 8-K, filed with the Commission on August 5, 2022, and incorporated herein by reference.](http://www.sec.gov/Archives/edgar/data/1430306/000138713122008450/ex3-01.htm) |

---

---

| | |
|:---|:---|
| [3.15](http://www.sec.gov/Archives/edgar/data/1430306/000138713122012368/ex3-01.htm) | [Certificate of Amendment to Tonix Pharmaceuticals Holding Corp.'s Articles of Incorporation, as amended, effective December 13, 2022, filed as an exhibit to the Current Report on Form 8-K, filed with the Commission on December 13, 2022, and incorporated herein by reference.](http://www.sec.gov/Archives/edgar/data/1430306/000138713122012368/ex3-01.htm) |

---

---

| | |
|:---|:---|
| [3.16](http://www.sec.gov/Archives/edgar/data/1430306/000138713123006247/ex3-01.htm) | [Certificate of Change of Tonix Pharmaceuticals Holding Corp.'s Articles of Incorporation, as amended, effective May 10, 2023, filed as an exhibit to the Current Report on Form 8-K, filed with the Commission on May 9, 2023, and incorporated herein by reference.](http://www.sec.gov/Archives/edgar/data/1430306/000138713123006247/ex3-01.htm) |

---

---

| | |
|:---|:---|
| [3.17](http://www.sec.gov/Archives/edgar/data/1430306/000199937124000837/ex3-01.htm) | [Certificate of Amendment to Tonix Pharmaceuticals Holding Corp.'s Articles of Incorporation, as amended, effective January 25, 2024, filed as an exhibit to the Current Report on Form 8-K, filed with the Commission on January 25, 2024, and incorporated herein by reference.](http://www.sec.gov/Archives/edgar/data/1430306/000199937124000837/ex3-01.htm) |

---

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| | |
|:---|:---|
| [4.01](http://www.sec.gov/Archives/edgar/data/1430306/000161577418004308/s110252_ex4-1.htm) | [Specimen Common Stock Certificate of the Registrant, filed as an exhibit to the Current Report on Form 8-K, filed with the Commission on May 24, 2018, and incorporated herein by reference.](http://www.sec.gov/Archives/edgar/data/1430306/000161577418004308/s110252_ex4-1.htm) |

---

4.02 Specimen
 Preferred Stock Certificate\*

4.03 Form
 of Warrant Agreement, including form of Warrant\*

[4.04](http://www.sec.gov/Archives/edgar/data/1430306/000199937125007635/ex4-04.htm) [Form of Senior Debt Indenture](http://www.sec.gov/Archives/edgar/data/1430306/000199937125007635/ex4-04.htm)\*\*\*

[4.05](http://www.sec.gov/Archives/edgar/data/1430306/000199937125007635/ex4-05.htm) [Form of Subordinated Debt Indenture](http://www.sec.gov/Archives/edgar/data/1430306/000199937125007635/ex4-05.htm)\*\*\*

4.06 Form
 of Senior Note (included in Exhibit 4.04)

4.07 Form
 of Subordinated Note (included in Exhibit 4.05)

4.08 Form
 of Unit Agreement\*

4.09 Form
 of Subscription Agreement\*

[5.01](http://www.sec.gov/Archives/edgar/data/1430306/000199937125007635/ex5-01.htm) [Opinion of Brownstein Hyatt Farber Schreck, LLP](http://www.sec.gov/Archives/edgar/data/1430306/000199937125007635/ex5-01.htm)\*\*\*

[5.02](http://www.sec.gov/Archives/edgar/data/1430306/000199937125007635/ex5-02.htm) [Opinion of Lowenstein Sandler, LLP](http://www.sec.gov/Archives/edgar/data/1430306/000199937125007635/ex5-02.htm)\*\*\*

[23.01](ex23-01.htm) [Consent of EisnerAmper LLP](ex23-01.htm)†

23.02 Consent
 of Brownstein Hyatt Farber Schreck, LLP (included in Exhibit 5.01)\*\*\*

23.03 Consent
 of Lowenstein Sandler, LLP (included in Exhibit 5.02)\*\*\*

23.04 Power
 of Attorney (contained on the signature pages to the registration statement)\*\*\*

25.1 Statement
 of Eligibility on Form T-1 of the Trustee for the Senior Debt Indenture\*\*

25.2 Statement
 of Eligibility on Form T-1 of the Trustee for the Subordinated Debt Indenture\*\*

[107](http://www.sec.gov/Archives/edgar/data/1430306/000199937125007635/ex107.htm) [Calculation of Filing Fee Table](http://www.sec.gov/Archives/edgar/data/1430306/000199937125007635/ex107.htm)\*\*\*

\* To be filed by amendment or as an exhibit to a Current Report on Form 8-K and incorporated herein by reference, if applicable.

\*\* To be filed pursuant to Section 305(b)(2) of the Trust Indenture Act of 1939, as amended. <br> \*\*\* Previously filed.

† Filed
 herewith.

**SIGNATURES**

Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing of the Registration Statement on Form S-3 and has duly caused this Form S-3 to be signed on its behalf by the undersigned, thereunto duly authorized, in Chatham, New Jersey, on the 4th day of September, 2025.

---

| | |
|:---|:---|
| **TONIX PHARMACEUTICALS HOLDING CORP.** | **TONIX PHARMACEUTICALS HOLDING CORP.** |
| By: | /s/ *SETH LEDERMAN* |
|  | Seth Lederman |
|  | Chief Executive Officer (Principal Executive Officer) |

---

**POWER OF ATTORNEY**

Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated:

---

| | | |
|:---|:---|:---|
| Signature | Title | Date |
| */s/ SETH LEDERMAN* | Chief Executive Officer (Principal Executive Officer) and Director | September 4, 2025 |
| Seth Lederman |  |  |
| \* | Chief Financial Officer (Principal Financial Officer and Principal Accounting Officer) | September 4, 2025 |
| Bradley Saenger |  |  |
| \* | Director | September 4, 2025 |
| Richard Bagger |  |  |
| *\** | Director | September 4, 2025 |
| Margaret Smith Bell |  |  |
| \* | Director | September 4, 2025 |
| David Grange |  |  |
| *\** | Director | September 4, 2025 |
| Adeoye Olukotun |  |  |
| *\** | Director | September 4, 2025 |
| Newcomb Stillwell |  |  |
| *\** | Director | September 4, 2025 |
| Carolyn E. Taylor |  |  |
| \* | Director | September 4, 2025 |
| James Treco |  |  |
| */s/ JAMES HUNTER* | Director | September 4, 2025 |
| James Hunter |  |  |

---

\*By:

---

| |
|:---|
| */s/ SETH LEDERMAN* |
| Seth Lederman, Attorney-in-Fact |

---

## Exhibit 23.01

[Tonix Pharmaceuticals Holding Corp. S-3/A](tnxp-s3a_090325.htm)

**Exhibit 23.01**

**CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM**

We consent to the incorporation by reference in this Amendment No. 1 to the Registration Statement of Tonix Pharmaceuticals Holding Corp. (the "Company") on Form S-3 (No. 333-287965) to be filed on or about September 4, 2025 of our report dated March 18, 2025, on our audits of the consolidated financial statements as of December 31, 2024 and 2023 and for each of the years then ended, which report was included in the Annual Report on Form 10-K filed March 18, 2025. Our report includes an explanatory paragraph about the existence of substantial doubt concerning the Company's ability to continue as a going concern. We also consent to the reference to our firm under the caption "Experts" in this Registration Statement.

/s/ EisnerAmper LLP

EISNERAMPER LLP

Iselin, New Jersey

September 4, 2025