# EDGAR Filing Document

**Accession Number:** 0002101801
**File Stem:** 0001453687-25-000143
**Filing Date:** 2025-12
**Character Count:** 8487
**Document Hash:** 976b178bd4142a01f869e15e181b241c
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001453687-25-000143.hdr.sgml**: 20251218

**ACCESSION NUMBER**: 0001453687-25-000143

**CONFORMED SUBMISSION TYPE**: 3

**PUBLIC DOCUMENT COUNT**: 5

**CONFORMED PERIOD OF REPORT**: 20251216

**FILED AS OF DATE**: 20251218

**DATE AS OF CHANGE**: 20251218

**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Bot Adrian Ion
- **CENTRAL INDEX KEY:** 0002101801

**ORGANIZATION NAME:**

**FILING VALUES:**
- **FORM TYPE:** 3
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-37798
- **FILM NUMBER:** 251583853

**MAIL ADDRESS:**
- **STREET 1:** 7495 NEW HORIZON WAY
- **CITY:** FREDERICK
- **STATE:** MD
- **ZIP:** 21703
**ISSUER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Cartesian Therapeutics, Inc.
- **CENTRAL INDEX KEY:** 0001453687
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**BUSINESS ADDRESS:**
- **STREET 1:** 7495 NEW HORIZON WAY
- **CITY:** FREDERICK
- **STATE:** MD
- **ZIP:** 21703
- **BUSINESS PHONE:** 301-348-8698

**MAIL ADDRESS:**
- **STREET 1:** 7495 NEW HORIZON WAY
- **CITY:** FREDERICK
- **STATE:** MD
- **ZIP:** 21703

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** SELECTA BIOSCIENCES INC
- **DATE OF NAME CHANGE:** 20090109

## Ex-24

![](cartesian-edgarpowerofat001.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;LIMITED POWER OF ATTORNEY FOR SEC REPORTING OBLIGATIONS Know all by these presents, that the undersigned hereby makes, constitutes and appoints each of Matthew Bartholomae, Mark Edlund, Sabrina Tompkins, and Mark Walko, signing singly and each acting individually, as the undersigned's true and lawful attorney-in-fact with full power and authority as hereinafter described to: (1) submit to the U.S. Securities and Exchange Commission (the "SEC") a Form ID Application and/or Passphrase Update Application or any other application materials to enable the undersigned to gain or maintain access to the Electronic Data Gathering, Analysis and Retrieval system of the SEC; (2) take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit to, in the best interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Limited Power of Attorney shall be in such form and shall contain such terms and conditions as such attorney-in-fact may approve in such attorney-in- fact's discretion; (3) execute for and on behalf of the undersigned, in the undersigned's capacity as an officer and/or director of Cartesian Therapeutics, Inc. (the "Company"), Forms 3, 4, 5, and 144 (including any amendments thereto) and Schedules 13D and 13G (including any amendments thereto); (4) do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to prepare, complete and execute any such Forms or Schedules, prepare, complete and execute any amendment or amendments thereto, and timely deliver and file such Forms or Schedules with the SEC and any stock exchange or similar authority; and (5) seek or obtain, as the undersigned's representative and on the undersigned's behalf, information regarding transactions in the Company's securities from any third party, including brokers, employee benefit plan administrators and trustees, and the undersigned hereby authorizes any such person to release any such information to such attorney-in-fact and approves and ratifies any such release of information. The undersigned hereby grants to each such attorney-in-fact full power and authority to do and perform any and every act and thing whatsoever requisite, necessary, or proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power of substitution or revocation, hereby ratifying and confirming all that such attorney-in-fact, or such attorney-in- fact's substitute or substitutes, shall lawfully do or cause to be done by virtue of this Limited Power of Attorney and the rights and powers herein granted. The undersigned acknowledges that the foregoing attorneys-in-fact, in serving in such capacity at the request of the undersigned, are

------

![](cartesian-edgarpowerofat002.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;[Signature Page to Power of Attorney] not assuming nor relieving, nor is the Company assuming nor relieving, any of the undersigned's responsibilities to comply with SEC filing obligations. The undersigned acknowledges that neither the Company nor the foregoing attorneys-in-fact assume (i) any liability for the undersigned's responsibility to comply with the requirements of SEC rules or (ii) any liability of the undersigned for any failure to comply with such requirements. This Limited Power of Attorney shall remain in full force and effect until such time as it is revoked by the undersigned in a signed writing delivered to the foregoing attorneys-in-fact. [Signature page follows.]

------

![](cartesian-edgarpowerofat003.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;[Signature Page to Power of Attorney] IN WITNESS WHEREOF, the undersigned has caused this Limited Power of Attorney to be executed as of this 18th day of December, 2025. /s/ Adrian Bot, M.D., Ph.D. Adrian Bot, M.D., Ph.D.

------

### UNITED STATES SECURITIES AND EXCHANGE COMMISSION
**Washington, D.C. 20549**

## FORM 3

### INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Bot Adrian Ion<br><sub>(Last) (First) (Middle)</sub><br>C/O CARTESIAN THERAPEUTICS, INC.<br>7495 NEW HORIZON WAY<br><sub>(Street)</sub><br>FREDRICK, MD 21703<br><sub>(City) (State) (Zip)</sub> | **3. Issuer Name and Ticker or Trading Symbol**<br>Cartesian Therapeutics, Inc. [ RNAC ] | **5. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  |
| **2. Date of Event Requiring Statement (Month/Day/Year)**<br>2025-12-16 | **4. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[X] Director   [ ] 10% Owner<br>[ ] Officer (give title below)   [ ] Other (specify below)<br>_ _ | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[X] Form filed by One Reporting Person<br>[ ] Form filed by More than One Reporting Person |

---

## Table I - Non-Derivative Securities Beneficially Owned

---

|  |  |  |  |
| --- | --- | --- | --- |
| 1. Title of Security | 2. Amount of Securities Beneficially Owned | 3. Ownership Form | 4. Nature of Indirect Beneficial Ownership |

---

## Table II - Derivative Securities Beneficially Owned

---

|  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- |
| 1. Title of Derivative Security | 2. Date Exercisable and Expiration Date (Month/Day/Year) | 2. Date Exercisable and Expiration Date (Month/Day/Year) | 3. Title and Amount of Underlying Securities | 3. Title and Amount of Underlying Securities | 4. Conversion or Exercise Price | 5. Ownership Form | 6. Nature of Indirect Beneficial Ownership |
| 1. Title of Derivative Security | Date Exercisable | Expiration Date | Title | Amount or Number of Shares | 4. Conversion or Exercise Price | 5. Ownership Form | 6. Nature of Indirect Beneficial Ownership |
|  |  |  |  |  |  |  |  |

---

**Remarks:**
Exhibit 24 - Power of Attorney

**Signature:** /s/ Matthew Bartholomae, Attorney-in-fact for Adrian Ion Bot  
**Date:** 2025-12-18

### Remarks:

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

**Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.**