# EDGAR Filing Document

**Accession Number:** 0001827087
**File Stem:** 0001193125-25-173607
**Filing Date:** 2025-8
**Character Count:** 7922
**Document Hash:** 43bafea25b0da8b7998cd38636a0c845
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-25-173607.hdr.sgml**: 20250805

**ACCESSION NUMBER**: 0001193125-25-173607

**CONFORMED SUBMISSION TYPE**: S-8 POS

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20250805

**DATE AS OF CHANGE**: 20250805

**EFFECTIVENESS DATE**: 20250805

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Vigil Neuroscience, Inc.
- **CENTRAL INDEX KEY:** 0001827087
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8 POS
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-262083
- **FILM NUMBER:** 251186083

**BUSINESS ADDRESS:**
- **STREET 1:** 100 FORGE ROAD
- **STREET 2:** SUITE 700
- **CITY:** WATERTOWN
- **STATE:** MA
- **ZIP:** 02472
- **BUSINESS PHONE:** 857-254-4445

**MAIL ADDRESS:**
- **STREET 1:** 100 FORGE ROAD
- **STREET 2:** SUITE 700
- **CITY:** WATERTOWN
- **STATE:** MA
- **ZIP:** 02472

**As filed with the Securities and Exchange Commission on August 5, 2025** 

**Registration No. 333-262083** 

**Registration No. 333-270711**

**Registration No. 333-278226**

**Registration No. 333-285766**

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**WASHINGTON, D.C. 20549** 

**POST-EFFECTIVE AMENDMENT TO** 

**Form S-8 Registration No. 333-262083**

**Form S-8 Registration No. 333-270711**

**Form S-8 Registration No. 333-278226**

**Form S-8 Registration No. 333-285766**

***UNDER***

***THE SECURITIES ACT OF 1933***

## VIGIL NEUROSCIENCE, INC.
**(Exact Name of Registrant as Specified in Its Charter)** 

---

| | |
|:---|:---|
| **Delaware** | **83-1880494** |
| **(State or Other Jurisdiction of**<br> **Incorporation or Organization)** | **(I.R.S. Employer**<br> **Identification No.)** |

---

**100 Forge Road, Suite 700** 

**Watertown, Massachusetts 02472** 

**(857) 254-4445** 

**(Address of Principal Executive Offices) (Zip Code)** 

**Vigil Neuroscience, Inc. Amended and Restated 2020 Equity Incentive Plan** 

**Vigil Neuroscience, Inc. 2021 Stock Option and Incentive Plan** 

**Vigil Neuroscience, Inc. 2021 Employee Stock Purchase Plan** 

**Vigil Neuroscience, Inc. Non-Qualified Stock Option Agreement for Inducement Award** 

**(Full title of the plans)** 

**Ivana Magovčević-Liebisch** 

**Chief Executive Officer** 

**Vigil Neuroscience, Inc.** 

**100 Forge Road, Suite 700** 

**Watertown, Massachusetts 02472** 

**(857) 254-4445** 

**(Name and address of agent for service) (Telephone number, including area code, of agent for service)** 

***Copies to:***

**Kingsley L. Taft, Esq.** 

**Jacqueline Mercier, Esq.** 

**Gabriela Morales-Rivera, Esq.** 

**Goodwin Procter LLP** 

**100 Northern Avenue** 

**Boston, MA 02210** 

**(617) 570-1000**

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.

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| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☐ | Accelerated filer | ☐ |
| Non-accelerated filer | ☒ | Smaller reporting company | ☒ |
|  |  | Emerging growth company | ☒ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

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**DEREGISTRATION OF SECURITIES** 

These Post-Effective Amendments (these "Post-Effective Amendments") relate to the following Registration Statements on Form S-8 (each, a "Registration Statement," and collectively, the "Registration Statements"), filed with the Securities and Exchange Commission (the "SEC") by Vigil Neuroscience, Inc., a Delaware corporation (the "Registrant"):

• Registration Statement No. [333-262083](http://www.sec.gov/Archives/edgar/data/1827087/000119312522005638/d287184ds8.htm) , filed with the SEC on January 10, 2022, pertaining to the registration of 3,086,742 shares of
common stock, par value $0.0001 per share ("Common Stock"), of the Registrant reserved for issuance under the Vigil Neuroscience, Inc. Amended and Restated 2020 Equity Incentive Plan, 3,145,281 shares of Common Stock reserved for issuance
under the Vigil Neuroscience, Inc. 2021 Stock Option and Incentive Plan (the "2021 Plan") and 286,127 shares of Common Stock reserved for issuance under the Vigil Neuroscience, Inc. 2021 Employee Stock Purchase Plan (the "ESPP");

• Registration Statement No. [333-270711](http://www.sec.gov/Archives/edgar/data/1827087/000119312523075366/d474346ds8.htm) , filed with the SEC on March 21, 2023, pertaining to the registration of an additional 1,781,016
shares of Common Stock reserved for issuance under the 2021 Plan and 286,127 shares of Common Stock reserved for issuance under the ESPP;

• Registration Statement No. [333-278226](http://www.sec.gov/Archives/edgar/data/1827087/000119312524077127/d807491ds8.htm) , filed with the SEC on March 26, 2024, pertaining to the registration of an additional 1,794,235
shares of Common Stock reserved for issuance under the 2021 Plan and 330,000 shares of Common Stock issuable under an inducement stock option award granted on March 18, 2024; and

• Registration Statement No. [333-285766](http://www.sec.gov/Archives/edgar/data/1827087/000119312525053506/d830252ds8.htm) , filed with the SEC on March 13, 2025, pertaining to the registration of an additional 2,044,338
shares of Common Stock reserved for issuance under the 2021 Plan.

On August 5, 2025, pursuant to the terms of the Agreement and Plan of Merger (the "Merger Agreement"), dated as of May 21, 2025, by and among the Registrant, Sanofi, a French *société anonyme* ("Sanofi"), and Vesper Acquisition Sub Inc., a Delaware corporation and a wholly-owned subsidiary of Sanofi ("Merger Sub"), Merger Sub merged with and into the Registrant (the "Merger"), with the Registrant surviving the Merger as a wholly-owned subsidiary of Sanofi.

As a result of the Merger, the Registrant has terminated, as of the date hereof, any and all offerings of its securities pursuant to its existing registration statements under the Securities Act of 1933, as amended, including the Registration Statements. In accordance with an undertaking made by the Registrant in the Registration Statements to remove from registration, by means of a post-effective amendment, any of the securities registered under the Registration Statements that remain unissued at the termination of the offerings, by filing these Post-Effective Amendments, the Registrant hereby removes from registration all securities registered but unsold under such Registration Statements, if any, as of the date hereof, and the Registration Statements are hereby amended, as appropriate, to reflect the deregistration of such securities.

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**SIGNATURES** 

Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused these Post-Effective Amendments to the Registration Statements on Form S-8 to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Watertown, Massachusetts, on August 5, 2025.

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| | |
|:---|:---|
| **VIGIL NEUROSCIENCE, INC.** | **VIGIL NEUROSCIENCE, INC.** |
| By: | /s/ Michael Tolpa |
|  | Name: Michael Tolpa |
|  | Title: Treasurer |

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No other person is required to sign these Post-Effective Amendments to the Registration Statements on Form S-8 in reliance on Rule 478 of the Securities Act of 1933, as amended.