# EDGAR Filing Document

**Accession Number:** 0001750698
**File Stem:** 0001213900-23-010900
**Filing Date:** 2023-2
**Character Count:** 16450
**Document Hash:** a1b95283d4ae4fd8c66983e51f5c88bd
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001213900-23-010900.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001213900-23-010900

**CONFORMED SUBMISSION TYPE**: SC 13G/A

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230213

**GROUP MEMBERS**: VIVO OPPORTUNITY, LLC

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Mereo Biopharma Group plc
- **CENTRAL INDEX KEY:** 0001719714
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** X0
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G/A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-91444
- **FILM NUMBER:** 23620441

**BUSINESS ADDRESS:**
- **STREET 1:** ONE CAVENDISH PLACE
- **STREET 2:** FOURTH FLOOR
- **CITY:** LONDON
- **STATE:** X0
- **ZIP:** W1G0QF
- **BUSINESS PHONE:** 4403330237300

**MAIL ADDRESS:**
- **STREET 1:** ONE CAVENDISH PLACE
- **STREET 2:** FOURTH FLOOR
- **CITY:** LONDON
- **STATE:** X0
- **ZIP:** W1G0QF
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Vivo Capital IX, LLC
- **CENTRAL INDEX KEY:** 0001750698
- **IRS NUMBER:** 824768569
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G/A

**BUSINESS ADDRESS:**
- **STREET 1:** 192 LYTTON AVENUE
- **CITY:** PALO ALTO
- **STATE:** CA
- **ZIP:** 94301
- **BUSINESS PHONE:** 6506880818

**MAIL ADDRESS:**
- **STREET 1:** 192 LYTTON AVENUE
- **CITY:** PALO ALTO
- **STATE:** CA
- **ZIP:** 94301

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**SCHEDULE 13G/A**

**Under the Securities Exchange Act of 1934**

**(Amendment No. 4) \***

**Mereo BioPharma Group plc**

(Name of Issuer)

**American Depositary Share, each representing five Ordinary Shares, nominal value £0.003 per share**

(Title of Class of Securities)

**589492107**

(CUSIP Number)

**December 31, 2022**

(Date of Event which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

☐ Rule 13d-1(b)

☒ Rule 13d-1(c)

☐ Rule 13d-1(d)

\* The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

&nbsp;&nbsp;CUSIP No. 589492107

---

| | |
|:---|:---|
| &nbsp;&nbsp;**1** | &nbsp;&nbsp;NAMES OF REPORTING PERSONS |
| &nbsp;&nbsp;**1** | &nbsp;&nbsp;&nbsp;**Vivo Capital IX, LLC** |
| &nbsp;&nbsp;**2** | &nbsp;&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) **** |
| &nbsp;&nbsp;**2** | &nbsp;&nbsp;&nbsp;(a) ☒ |
| &nbsp;&nbsp;**2** | &nbsp;&nbsp;&nbsp;(b) ☐ |
| &nbsp;&nbsp;**3** | &nbsp;&nbsp;SEC USE ONLY |
| &nbsp;&nbsp;**3** |  |
| &nbsp;&nbsp;**4** | &nbsp;&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION |
| &nbsp;&nbsp;**4** | &nbsp;&nbsp;&nbsp;**Delaware** |

---

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY <br> EACH <br> REPORTING <br> PERSON<br> WITH | &nbsp;&nbsp;**5** | &nbsp;&nbsp;SOLE VOTING POWER |
| &nbsp;&nbsp;NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY <br> EACH <br> REPORTING <br> PERSON<br> WITH | &nbsp;&nbsp;**5** | &nbsp;&nbsp;&nbsp;&nbsp;**839435 <sup>(1)</sup>** |
| &nbsp;&nbsp;NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY <br> EACH <br> REPORTING <br> PERSON<br> WITH | &nbsp;&nbsp;**6** | &nbsp;&nbsp;SHARED VOTING POWER |
| &nbsp;&nbsp;NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY <br> EACH <br> REPORTING <br> PERSON<br> WITH | &nbsp;&nbsp;**6** | &nbsp;&nbsp;&nbsp;&nbsp;**0** |
| &nbsp;&nbsp;NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY <br> EACH <br> REPORTING <br> PERSON<br> WITH | &nbsp;&nbsp;**7** | &nbsp;&nbsp;SOLE DISPOSITIVE POWER |
| &nbsp;&nbsp;NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY <br> EACH <br> REPORTING <br> PERSON<br> WITH | &nbsp;&nbsp;**7** | &nbsp;&nbsp;&nbsp;&nbsp;**839435 <sup>(1)</sup>** |
| &nbsp;&nbsp;NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY <br> EACH <br> REPORTING <br> PERSON<br> WITH | &nbsp;&nbsp;**8** | &nbsp;&nbsp;SHARED DISPOSITIVE POWER |
| &nbsp;&nbsp;NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY <br> EACH <br> REPORTING <br> PERSON<br> WITH | &nbsp;&nbsp;**8** | &nbsp;&nbsp;&nbsp;&nbsp;**0** |

---

---

| | |
|:---|:---|
| &nbsp;&nbsp;**9** | &nbsp;&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| &nbsp;&nbsp;**9** | &nbsp;&nbsp;**839435 <sup>(1)</sup>** |
| &nbsp;&nbsp;**10** | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions) |
| &nbsp;&nbsp;**10** | &nbsp;&nbsp;☐ |
| &nbsp;&nbsp;**11** | &nbsp;&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
| &nbsp;&nbsp;**11** | &nbsp;&nbsp;**0.7% <sup>(2)</sup>** |
| &nbsp;&nbsp;**12** | &nbsp;&nbsp;TYPE OF REPORTING PERSON (See Instructions) |
| &nbsp;&nbsp;**12** | &nbsp;&nbsp;&nbsp;**OO** |

---

<sup>(1)</sup> The number represents 839,435 American Depositary Shares ("ADS") of Mereo BioPharma Group plc (the "Issuer"), with each ADS representing 5 ordinary shares, nominal value £0.003 per share (the "Ordinary Share") of the Issuer, issuable upon exercise of certain warrants. The warrants are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the general partner of Vivo Capital Fund IX, L.P.

<sup>(2)</sup> Based on (i)116,778,489 ADSs of the Issuer outstanding as of June 30, 2022, as disclosed in the Issuer's 6-K, filed with the Securities and Exchange Commission (the "SEC") on November 2, 2022 and (ii) 839,435 ADSs, issuable upon exercise of certain warrants held of records by Vivo Capital Fund IX, L.P.

&nbsp;&nbsp;CUSIP No. 589492107

---

| | |
|:---|:---|
| &nbsp;&nbsp;**1** | &nbsp;&nbsp;NAMES OF REPORTING PERSONS |
| &nbsp;&nbsp;**1** | &nbsp;&nbsp;&nbsp;**Vivo Opportunity, LLC** |
| &nbsp;&nbsp;**2** | &nbsp;&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) **** |
| &nbsp;&nbsp;**2** | &nbsp;&nbsp;&nbsp;(a) ☒ |
| &nbsp;&nbsp;**2** | &nbsp;&nbsp;&nbsp;(b) ☐ |
| &nbsp;&nbsp;**3** | &nbsp;&nbsp;SEC USE ONLY |
| &nbsp;&nbsp;**3** |  |
| &nbsp;&nbsp;**4** | &nbsp;&nbsp;CITIZENSHIP OR PLACE OF ORGANIZATION |
| &nbsp;&nbsp;**4** | &nbsp;&nbsp;&nbsp;**Delaware** |

---

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp; NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY <br> EACH <br> REPORTING <br> PERSON<br> WITH | &nbsp;&nbsp;**5** | &nbsp;&nbsp;SOLE VOTING POWER |
| &nbsp;&nbsp; NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY <br> EACH <br> REPORTING <br> PERSON<br> WITH | &nbsp;&nbsp;**5** | &nbsp;&nbsp;&nbsp;&nbsp;**3761947 <sup>(1)</sup>** |
| &nbsp;&nbsp; NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY <br> EACH <br> REPORTING <br> PERSON<br> WITH | &nbsp;&nbsp;**6** | &nbsp;&nbsp;SHARED VOTING POWER |
| &nbsp;&nbsp; NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY <br> EACH <br> REPORTING <br> PERSON<br> WITH | &nbsp;&nbsp;**6** | &nbsp;&nbsp;&nbsp;&nbsp;**0** |
| &nbsp;&nbsp; NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY <br> EACH <br> REPORTING <br> PERSON<br> WITH | &nbsp;&nbsp;**7** | &nbsp;&nbsp;SOLE DISPOSITIVE POWER |
| &nbsp;&nbsp; NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY <br> EACH <br> REPORTING <br> PERSON<br> WITH | &nbsp;&nbsp;**7** | &nbsp;&nbsp;&nbsp;&nbsp;**3761947 <sup>(1)</sup>** |
| &nbsp;&nbsp; NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY <br> EACH <br> REPORTING <br> PERSON<br> WITH | &nbsp;&nbsp;**8** | &nbsp;&nbsp;SHARED DISPOSITIVE POWER |
| &nbsp;&nbsp; NUMBER OF <br> SHARES <br> BENEFICIALLY <br> OWNED BY <br> EACH <br> REPORTING <br> PERSON<br> WITH | &nbsp;&nbsp;**8** | &nbsp;&nbsp;&nbsp;&nbsp;**0** |

---

---

| | |
|:---|:---|
| &nbsp;&nbsp;**9** | &nbsp;&nbsp;AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON |
| &nbsp;&nbsp;**9** | &nbsp;&nbsp;**3761947 <sup>(1)</sup>** |
| &nbsp;&nbsp;**10** | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions) |
| &nbsp;&nbsp;**10** | &nbsp;&nbsp;☐ |
| &nbsp;&nbsp;**11** | &nbsp;&nbsp;PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) |
| &nbsp;&nbsp;**11** | &nbsp;&nbsp;**3.1% <sup>(2)</sup>** |
| &nbsp;&nbsp;**12** | &nbsp;&nbsp;TYPE OF REPORTING PERSON (See Instructions) |
| &nbsp;&nbsp;**12** | &nbsp;&nbsp;&nbsp;**OO** |

---

 

<sup>(1)</sup> The number represents 3,761,947 ADSs, issuable upon exercise of certain warrants. The warrants are held of record by Vivo Opportunity Fund Holdings, L.P. Vivo Opportunity, LLC is the general partner of Vivo Opportunity Fund Holdings, L.P.

<sup>(2)</sup> Based on (i)116,778,489 ADSs of the Issuer outstanding as of June 30, 2022, as disclosed in the Issuer's 6-K, filed with the SEC on November 2, 2022 and (ii) 3,761,947 ADSs, issuable upon exercise of certain warrants held of records by Vivo Opportunity Fund Holdings, L.P.

---

| | |
|:---|:---|
| **Item 1** **. (a)** | **Name of Issuer** **:** |

---

Mereo BioPharma Group plc

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Address of Issuer's
Principal Executive Offices:

4th Floor, One Cavendish Place,

London, W1G 0QF, United Kingdom

Item 2. (a) Name of Person Filing:

This Amendment No. 4 to Schedule 13G is filed jointly by Vivo Capital IX, LLC and Vivo Opportunity, LLC.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Address of Principal Business Office or, if None, Residence:

192 Lytton Avenue, Palo Alto, CA 94301

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Citizenship:

Vivo Capital IX, LLC is a Delaware limited liability company.

Vivo Opportunity, LLC is a Delaware limited liability company.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) Title of Class of Securities:

Ordinary Shares, nominal value £0.003, represented by American Depositary Shares, each of which represents five Ordinary Shares.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) CUSIP Number:

589492107

Item 3. If This Statement is Filed Pursuant to §§ 240.13d-1(b), or 240.13d-2(b) or (c), Check Whether the Person Filing is a:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) ☐ Broker or dealer registered under Section 15 of the Act.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ☐ Bank as defined in Section 3(a)(6) of the Act.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) ☐ Insurance company as defined in Section 3(a)(19) of the Act.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) ☐ Investment company registered under Section 8 of the Investment Company Act of 1940.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) ☐ An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E) ;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) ☐ An employee benefit plan or endowment fund in accordance with § 240.13d-1 (b)(1)(ii)(F);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) ☐ A parent holding company or control person in accordance with § 240.13d-1 (b)(l)(ii)(G);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) ☐ A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) ☐ A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company
Act;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(j) ☐ A non-U.S. institution in accordance with § 240.13d-1 (b)(1)(ii)(J);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(k) ☐ Group, in accordance with § 240.13d-1 (b)(l)(ii)(K).

If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1(ii)(j), please specify the type of institution: ________________

Not Applicable.

Item 4. Ownership.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Amount beneficially owned:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) Vivo Capital
IX, LLC

The 839,435 ADSs, issuable upon exercise of certain warrants, are held of record by Vivo Capital Fund IX, L.P. Vivo Capital IX, LLC is the general partner of Vivo Capital Fund IX, L.P. The voting members of Vivo Capital IX, LLC are Frank Kung, Edgar Engleman, Shan Fu, Hongbo Lu, Mahendra Shah, Jack Nielsen and Michael Chang, none of whom has individual voting or investment power with respect to these warrants and each of whom disclaims beneficial ownership of such warrants.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) Vivo Opportunity,
LLC

The 3,761,947 ADSs, issuable upon exercise of certain warrants, are held of record by Vivo Opportunity Fund Holdings, L.P. Vivo Opportunity, LLC is the general partner of Vivo Opportunity Fund Holdings, L.P. The voting members of Vivo Opportunity, LLC are Gaurav Aggarwal, Hongbo Lu, Kevin Dai, Frank Kung and Michael Chang, none of whom has individual voting or investment power with respect to these warrants and each of whom disclaims beneficial ownership of such warrants.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Percent of class:

Vivo Capital IX, LLC: 0.7%

Vivo Opportunity, LLC: 3.1%

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Number of shares as
to which such person has:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) Sole power
to vote or to direct the vote:

Vivo Capital IX, LLC: 839,435 ADSs

Vivo Opportunity, LLC: 3,761,947 ADSs

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) Shared
power to vote or to direct the vote: 0

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) Sole power
to dispose or to direct the disposition of:

Vivo Capital IX, LLC: 839,435 ADSs

Vivo Opportunity, LLC: 3,761,947 ADSs

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) Shared
power to dispose of or to direct the disposition of: 0

Item 5. Ownership of Five Percent or Less of a Class.

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than 5 percent of the class of securities, check the following ☒

Item 6. Ownership of More than Five Percent on Behalf of Another Person.

Not Applicable.

Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.

Not Applicable.

Item 8. Identification and Classification of Members of the Group.

Not applicable.

Item 9. Notice of Dissolution of Group.

Not applicable.

Item 10. Certifications.

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under §240.14a11.

**SIGNATURE**

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

---

| |
|:---|
| **Vivo Capital IX, LLC** |
| February 13, 2023 |
| (Date) |
| /s/ Frank Kung |
| (Signature) |
| Managing Member |
| (Title) |
| **Vivo Opportunity, LLC** |
| February 13, 2023 |
| (Date) |
| /s/ <u>Gaurav Aggarwal</u> |
| (Signature) |
| Managing Member |
| (Title) |

---