# EDGAR Filing Document

**Accession Number:** 0001355064
**File Stem:** 0000910472-25-004697
**Filing Date:** 2025-11
**Character Count:** 24226
**Document Hash:** 691db4f1afb35f698e95a49da15a130c
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000910472-25-004697.hdr.sgml**: 20251126

**ACCESSION NUMBER**: 0000910472-25-004697

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20250930

**FILED AS OF DATE**: 20251126

**DATE AS OF CHANGE**: 20251126

**PERIOD START**: 20260331

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** MUTUAL FUND SERIES TRUST
- **CENTRAL INDEX KEY:** 0001355064

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** OH
- **FISCAL YEAR END:** 0630

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-21872
- **FILM NUMBER:** 251531039

**BUSINESS ADDRESS:**
- **STREET 1:** C/O GEMINI FUND SERVICES LLC
- **STREET 2:** 4221 NORTH 203RD STREET, SUITE 100
- **CITY:** ELKHORN
- **STATE:** NE
- **ZIP:** 68022-3474
- **BUSINESS PHONE:** 631 549 1859

**MAIL ADDRESS:**
- **STREET 1:** C/O GEMINI FUND SERVICES LLC
- **STREET 2:** 4221 NORTH 203RD STREET, SUITE 100
- **CITY:** ELKHORN
- **STATE:** NE
- **ZIP:** 68022-3474

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** CATALYST FUNDS
- **DATE OF NAME CHANGE:** 20060303

## Series and Classes Contracts Data

### AlphaCentric Life Sciences and Healthcare Fund (Series ID: S000067055)

| Class ID   | Class Name                                             | Ticker Symbol   |
|:---|:---|:---|
| C000215729 | AlphaCentric Life Sciences and Healthcare Fund Class C | LYFCX           |
| C000215730 | AlphaCentric Life Sciences and Healthcare Fund Class I | LYFIX           |
| C000215731 | AlphaCentric Life Sciences and Healthcare Fund Class A | LYFAX           |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** MUTUAL FUND SERIES TRUST

- **b. Investment Company Act file number:** 811-21872

- **c. CIK number of Registrant:** 0001355064

- **d. LEI of Registrant:** 5493002ZGLQMLR4QMA96

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** C/O GEMINI FUND SERVICES LLC

  - **City:** ELKHORN

  - **State:** NE

  - **Foreign country:** US

  - **Zip / Postal Code:** 68022

  - **Telephone number:** 631-470-2600

**Item A.2. Information about the Series.**

- **a. Name of Series:** AlphaCentric Life Sciences and Healthcare Fund

- **b. EDGAR series identifier (if any):** S000067055

- **c. LEI of Series:** 549300XV4TMPQ6UX8179

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2026-03-31

- **b. Date as of which information is reported:** 2025-09-30

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $35014705.00

**Total Liabilities:** $152481.78

**Net Assets:** $34862223.22

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000215729 | -1.60%               | 6.58%                | 5.53%                |
| Class ID C000215731 | -1.56%               | 6.68%                | 5.63%                |
| Class ID C000215730 | -1.55%               | 6.62%                | 5.66%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $-386276.86              | $-96551.46                                 |
| Month 2  | $-1323431.83             | $3413974.78                                |
| Month 3  | $74986.27                | $1824489.09                                |

### Schedule of Portfolio Investments

| Name                                | Title                  | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| IQVIA Holdings Inc.                 | IQVIA HOLDINGS I       | CUSIP: 46266C105<br>LEI: 549300W3R20NM4KQPH86 | Long             | EC               | CORP              | US        |       883 | NS      | $167717.02    | 0.48%             |  |  |  | No            |                  1 | On Loan: No      |
| Janux Therapeutics Inc              | JANUX THERAPEUTI       | CUSIP: 47103J105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5299 | NS      | $129507.56    | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Sanofi SA                           | SANOFI-ADR             | CUSIP: 80105N105<br>LEI: 549300E9PC51EN656011 | Long             | EC               | CORP              | FR        |     11123 | NS      | $525005.60    | 1.51%             |  |  |  | No            |                  1 | On Loan: No      |
| Day One Biopharmaceuticals Inc.     | DAY ONE BIOPHARM       | CUSIP: 23954D109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     30469 | NS      | $214806.45    | 0.62%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytokinetics Inc                    | CYTOKINETICS INC       | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |      6035 | NS      | $331683.60    | 0.95%             |  |  |  | No            |                  1 | On Loan: No      |
| Verona Pharma Plc                   | VERONA PHAR-ADR        | CUSIP: 925050106<br>LEI: 213800EVI6O6J3TIAL06 | Long             | EC               | CORP              | GB        |      9568 | NS      | $1021001.28   | 2.93%             |  |  |  | No            |                  1 | On Loan: No      |
| AstraZeneca PLC                     | ASTRAZENECA-ADR        | CUSIP: 046353108<br>LEI: PY6ZZQWO2IZFZC3IOL08 | Long             | EC               | CORP              | GB        |     24140 | NS      | $1852020.80   | 5.31%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals Incorporated | VERTEX PHARM           | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |      5299 | NS      | $2075300.36   | 5.95%             |  |  |  | No            |                  1 | On Loan: No      |
| Axsome Therapeutics Inc.            | AXSOME THERAPEUT       | CUSIP: 05464T104<br>LEI: 549300EXGR0XLRJEIB95 | Long             | EC               | CORP              | US        |      6918 | NS      | $840191.10    | 2.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Design Therapeutics Inc.            | DESIGN THERAPEUT       | CUSIP: 25056L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     13690 | NS      | $103085.70    | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Avadel Pharmaceuticals PLC          | AVADEL PHARMACEU       | CUSIP: G29687103<br>LEI: 549300E27PTSG2RHC762 | Long             | EC               | CORP              | IE        |     42833 | NS      | $654059.91    | 1.88%             |  |  |  | No            |                  1 | On Loan: No      |
| Immunome Inc                        | IMMUNOME INC           | CUSIP: 45257U108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     14719 | NS      | $172359.49    | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvalent Inc                        | NUVALENT INC-A         | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5004 | NS      | $432745.92    | 1.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcturus Therapeutics Holdings Inc  | ARCTURUS THERAPE       | CUSIP: 03969T109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     10598 | NS      | $195321.14    | 0.56%             |  |  |  | No            |                  1 | On Loan: No      |
| First American Funds Inc.           | FIRST AM-TR OB-X       | CUSIP: 31846V328<br>LEI: 549300J5J5SJCZ9IA369 | Long             | STIV             | RF                | US        |   1198844 | PA      | $1198844.44   | 3.44%             |  |  |  | No            |                  1 | On Loan: No      |
| Arbutus Biopharma Corp.             | ARBUTUS BIOPHARM       | CUSIP: 03879J100<br>LEI: 25490064CESONAUIAS23 | Long             | EC               | CORP              | CA        |     54463 | NS      | $247262.02    | 0.71%             |  |  |  | No            |                  1 | On Loan: No      |
| BioNTech SE                         | BIONTECH SE-ADR        | CUSIP: 09075V102<br>LEI: 894500UZJ5LG1F8J1U58 | Long             | EC               | CORP              | DE        |      6035 | NS      | $595171.70    | 1.71%             |  |  |  | No            |                  1 | On Loan: No      |
| Black Diamond Therapeutics Inc      | BLACK DIAMOND TH       | CUSIP: 09203E105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     60939 | NS      | $230958.81    | 0.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Disc Medicine Inc                   | DISC MEDICINE IN       | CUSIP: 254604101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4268 | NS      | $282029.44    | 0.81%             |  |  |  | No            |                  1 | On Loan: No      |
| Intellia Therapeutics Inc           | INTELLIA THERAPE       | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |     12364 | NS      | $213526.28    | 0.61%             |  |  |  | No            |                  1 | On Loan: No      |
| Rhythm Pharmaceuticals Inc          | RHYTHM PHARMACEU       | CUSIP: 76243J105<br>LEI: 529900JPNWXQ8DPLA551 | Long             | EC               | CORP              | US        |      5733 | NS      | $578975.67    | 1.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Arvinas Inc                         | ARVINAS INC            | CUSIP: 04335A105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     14131 | NS      | $120396.12    | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Gilead Sciences Inc.                | GILEAD SCIENCES        | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |     24729 | NS      | $2744919.00   | 7.87%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals Inc.        | ALNYLAM PHARMACE       | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |      1472 | NS      | $671232.00    | 1.93%             |  |  |  | No            |                  1 | On Loan: No      |
| Apogee Therapeutics Inc.            | APOGEE THERAPEUT       | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     12218 | NS      | $485421.14    | 1.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Rezolute Inc                        | REZOLUTE INC           | CUSIP: 76200L309<br>LEI: 549300T05L48T72P2G08 | Long             | EC               | CORP              | US        |     13690 | NS      | $128686.00    | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Argenx SE                           | ARGENX SE - ADR        | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |      1619 | NS      | $1194109.64   | 3.43%             |  |  |  | No            |                  1 | On Loan: No      |
| Exact Sciences Corporation          | EXACT SCIENCES         | CUSIP: 30063P105<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |      8979 | NS      | $491241.09    | 1.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Amgen Inc.                          | AMGEN INC              | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |      2503 | NS      | $706346.60    | 2.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Adma Biologics Inc                  | ADMA BIOLOGICS I       | CUSIP: 000899104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8684 | NS      | $127307.44    | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| NewAmsterdam Pharma Company NV      | NEWAMSTERDAM PHA       | CUSIP: N62509109<br>LEI: 984500B6549TF6E14D36 | Long             | EC               | CORP              | NL        |     12511 | NS      | $355812.84    | 1.02%             |  |  |  | No            |                  1 | On Loan: No      |
| AbbVie Inc.                         | ABBVIE INC             | CUSIP: 00287Y109<br>LEI: FR5LCKFTG8054YNNRU85 | Long             | EC               | CORP              | US        |      3385 | NS      | $783762.90    | 2.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Personalis Inc                      | PERSONALIS INC         | CUSIP: 71535D106<br>LEI: 549300EZ2NYFK7H0US48 | Long             | EC               | CORP              | US        |     54315 | NS      | $354133.80    | 1.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Kymera Therapeutics Inc             | KYMERA THERAPEUT       | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4416 | NS      | $249945.60    | 0.72%             |  |  |  | No            |                  1 | On Loan: No      |
| Roivant Sciences Ltd                | ROIVANT SCIENCES       | CUSIP: G76279101<br>LEI: 549300DL466NY5J6U724 | Long             | EC               | CORP              | BM        |     51224 | NS      | $775019.12    | 2.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Capricor Therapeutics Inc           | CAPRICOR THERAPE       | CUSIP: 14070B309<br>LEI: 5493002ZI5PDLXV4DX14 | Long             | EC               | CORP              | US        |     18694 | NS      | $134783.74    | 0.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Tectonic Therapeutic Inc            | TECTONIC THERAPE       | CUSIP: 878972108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7360 | NS      | $115478.40    | 0.33%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen Inc                          | BIOGEN INC             | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |      4121 | NS      | $577269.68    | 1.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Agios Pharmaceuticals Inc           | AGIOS PHARMACEUT       | CUSIP: 00847X104<br>LEI: 529900ONJHY8EOGYT555 | Long             | EC               | CORP              | US        |      5411 | NS      | $217197.54    | 0.62%             |  |  |  | No            |                  1 | On Loan: No      |
| Ascendis Pharma A/S                 | ASCENDIS PHA-ADR       | CUSIP: 04351P101<br>LEI: 549300B66JN3W3J8GH73 | Long             | EC               | CORP              | DK        |      3680 | NS      | $731620.80    | 2.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Halozyme Therapeutics Inc           | HALOZYME THERAPE       | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |      5152 | NS      | $377847.68    | 1.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Scholar Rock Holding Corp.          | SCHOLAR ROCK HOL       | CUSIP: 80706P103<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |     11187 | NS      | $416603.88    | 1.20%             |  |  |  | No            |                  1 | On Loan: No      |
| GoodRx Holdings Inc                 | GOODRX HOLDIN-A        | CUSIP: 38246G108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     23404 | NS      | $98998.92     | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| MDXHealth SA                        | MDXHEALTH              | CUSIP: B5950S113<br>LEI: 549300J3MG9F9B5FY646 | Long             | EC               | CORP              | BE        |     85373 | NS      | $396984.45    | 1.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Soleno Therapeutics Inc             | SOLENO THERAPEUT       | CUSIP: 834203309<br>LEI: 5493003LCY77N7FXK844 | Long             | EC               | CORP              | US        |      3680 | NS      | $248768.00    | 0.71%             |  |  |  | No            |                  1 | On Loan: No      |
| Protagonist Therapeutics Inc        | PROTAGONIST THER       | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      9715 | NS      | $645367.45    | 1.85%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences Inc          | NEUROCRINE BIOSC       | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |      8390 | NS      | $1177788.20   | 3.38%             |  |  |  | No            |                  1 | On Loan: No      |
| Artivion Inc                        | ARTIVION INC           | CUSIP: 228903100<br>LEI: 549300YTKV8DMSMG6K81 | Long             | EC               | CORP              | US        |      4600 | NS      | $194764.00    | 0.56%             |  |  |  | No            |                  1 | On Loan: No      |
| Incyte Corporation.                 | INCYTE CORP            | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |     15308 | NS      | $1298271.48   | 3.72%             |  |  |  | No            |                  1 | On Loan: No      |
| Catalyst Pharmaceuticals Inc.       | CATALYST PHARMAC       | CUSIP: 14888U101<br>LEI: 5299004O0R5XXLA5H544 | Long             | EC               | CORP              | US        |     25023 | NS      | $492953.10    | 1.41%             |  |  |  | No            |                  1 | On Loan: No      |
| MeiraGTx Holdings PLC               | MEIRAGTX HOLDING       | CUSIP: G59665102<br>LEI: 54930007YV6NYIOGFZ57 | Long             | EC               | CORP              | KY        |     32383 | NS      | $266512.09    | 0.76%             |  |  |  | No            |                  1 | On Loan: No      |
| Trevi Therapeutics Inc              | TREVI THERAPEUTICS INC | CUSIP: 89532M101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     25759 | NS      | $235694.85    | 0.68%             |  |  |  | No            |                  1 | On Loan: No      |
| Avidity Biosciences Inc.            | AVIDITY BIOSCIEN       | CUSIP: 05370A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7785 | NS      | $339192.45    | 0.97%             |  |  |  | No            |                  1 | On Loan: No      |
| Cullinan Therapeutics Inc           | CULLINAN ONCOLOG       | CUSIP: 230031106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     21638 | NS      | $128313.34    | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Oruka Therapeutics Inc              | ORUKA THERAPEUTI       | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |     12364 | NS      | $237759.72    | 0.68%             |  |  |  | No            |                  1 | On Loan: No      |
| Fidelity Colchester Street Trust    | FID-MM GOVT-I          | CUSIP: 316175108<br>LEI: 549300SHPEJB1OPRCV46 | Long             | STIV             | RF                | US        |         2 | PA      | $1.57         | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Natera Inc.                         | NATERA INC             | CUSIP: 632307104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1472 | NS      | $236947.84    | 0.68%             |  |  |  | No            |                  1 | On Loan: No      |
| Insmed Inc                          | INSMED INC             | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |     10010 | NS      | $1441540.10   | 4.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Edgewise Therapeutics Inc.          | EDGEWISE THERAPE       | CUSIP: 28036F105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     21343 | NS      | $346183.46    | 0.99%             |  |  |  | No            |                  1 | On Loan: No      |
| Nurix Therapeutics Inc.             | NURIX THERAPEUTI       | CUSIP: 67080M103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     14131 | NS      | $130570.44    | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Wave Life Sciences Ltd.             | WAVE LIFE SCIENCES LTD | CUSIP: Y95308105<br>LEI: 54930070006GPKFYZ813 | Long             | EC               | CORP              | SG        |     31353 | NS      | $229503.96    | 0.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Jazz Pharmaceuticals PLC            | JAZZ PHARMACEUTI       | CUSIP: G50871105<br>LEI: 635400GAUMJCLEZRRV50 | Long             | EC               | CORP              | IE        |      3830 | NS      | $504794.00    | 1.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Ionis Pharmaceuticals, Inc.         | IONIS PHARMACEUT       | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |     21049 | NS      | $1377025.58   | 3.95%             |  |  |  | No            |                  1 | On Loan: No      |
| Krystal Biotech Inc                 | KRYSTAL BIOTECH        | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |      3680 | NS      | $649630.40    | 1.86%             |  |  |  | No            |                  1 | On Loan: No      |
| Xeris Biopharma Holdings Inc        | XERIS BIOPHARMA        | CUSIP: 98422E103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     49311 | NS      | $401391.54    | 1.15%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2025-10-28

**Name of Applicant:** MUTUAL FUND SERIES TRUST

**Signature:** Erik Naviloff

**Name of Signer:** Erik Naviloff

**Title:** Treasurer