# EDGAR Filing Document

**Accession Number:** 0001385818
**File Stem:** 0001437749-25-019197
**Filing Date:** 2025-6
**Character Count:** 3235
**Document Hash:** a17b5114f3d591a851a110a14d132872
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001437749-25-019197.hdr.sgml**: 20250707

**ACCESSION NUMBER**: 0001437749-25-019197

**CONFORMED SUBMISSION TYPE**: CORRESP

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20250602

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** AYTU BIOPHARMA, INC
- **CENTRAL INDEX KEY:** 0001385818
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 470883144
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 0630

**FILING VALUES:**
- **FORM TYPE:** CORRESP

**BUSINESS ADDRESS:**
- **STREET 1:** 7900 E. UNION AVENUE
- **STREET 2:** SUITE 920
- **CITY:** DENVER
- **STATE:** CO
- **ZIP:** 80237
- **BUSINESS PHONE:** (720) 437-6580

**MAIL ADDRESS:**
- **STREET 1:** 7900 E. UNION AVENUE
- **STREET 2:** SUITE 920
- **CITY:** DENVER
- **STATE:** CO
- **ZIP:** 80237

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** AYTU BIOSCIENCE, INC
- **DATE OF NAME CHANGE:** 20150609

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** AYTU BIOSCIENCE, INC.
- **DATE OF NAME CHANGE:** 20150609

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Rosewind CORP
- **DATE OF NAME CHANGE:** 20070110

June 2, 2025

**<u>VIA EDGAR</u>**

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

---

| | |
|:---|:---|
| **Re:** | **Aytu BioPharma, Inc.** <br> **Registration Statement on Form S-1** <br> **File No. 333-287728**<br> **Request for Acceleration of Effective Date**  |

---

Ladies and Gentlemen:

Pursuant to Rule 461 of the General Rules and Regulations under the Securities Act of 1933, as amended (the "<u>Securities Act</u>"), Lake Street Capital Markets LLC, as the representative of several underwriters, hereby join in the request of Aytu BioPharma, Inc. for acceleration of the effective date of the above-referenced registration statement on Form S-1, as amended (the "<u>Registration Statement</u>"), so that it becomes effective as of 5:00 p.m. Eastern Time on Wednesday, June 4, 2025, or as soon thereafter as possible.

Pursuant to Rule 460 of the General Rules and Regulations of the Securities Act, please be advised that there will be distributed to each underwriter, who is reasonably anticipated to be invited to participate in the distribution of the security, as many copies of the proposed form of preliminary prospectus as appears to be reasonable to secure adequate distribution of the preliminary prospectus.

The undersigned has and will comply, and it has been informed or will be informed by any participating dealers that they have complied or will comply, with the requirements of Rule 15c2-8 under the Securities Exchange Act of 1934, as amended.

*[Signature Page to Follow]*

------

---

| | |
|:---|:---|
| Very truly yours,<br>**LAKE STREET CAPITAL MARKETS LLC**<br>*on behalf of itself and as representative of the Underwriters* | Very truly yours,<br>**LAKE STREET CAPITAL MARKETS LLC**<br>*on behalf of itself and as representative of the Underwriters* |
| By:  | /s/ Michael Townley |
| Name: | Michael Townley |
| Title: | Head of Investment Banking |

---

*[Signature Page to Underwriter*'*s Acceleration Request]*