# EDGAR Filing Document

**Accession Number:** 0001759138
**File Stem:** 0000902664-23-001805
**Filing Date:** 2023-2
**Character Count:** 16828
**Document Hash:** c3f827e21ae83b2e7ea015ea3eb68387
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000902664-23-001805.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0000902664-23-001805

**CONFORMED SUBMISSION TYPE**: SC 13G/A

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Cabaletta Bio, Inc.
- **CENTRAL INDEX KEY:** 0001759138
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G/A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-91178
- **FILM NUMBER:** 23629074

**BUSINESS ADDRESS:**
- **STREET 1:** 2929 ARCH STREET
- **STREET 2:** SUITE 600
- **CITY:** PHILADELPHIA
- **STATE:** PA
- **ZIP:** 19104
- **BUSINESS PHONE:** (267) 759-3100

**MAIL ADDRESS:**
- **STREET 1:** 2929 ARCH STREET
- **STREET 2:** SUITE 600
- **CITY:** PHILADELPHIA
- **STATE:** PA
- **ZIP:** 19104
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Lynx1 Capital Management LP
- **CENTRAL INDEX KEY:** 0001910456
- **IRS NUMBER:** 851134656
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G/A

**BUSINESS ADDRESS:**
- **STREET 1:** 151 CALLE DE SAN FRANCISCO
- **STREET 2:** SUITE 200 PMB 1237
- **CITY:** SAN JUAN
- **STATE:** PR
- **ZIP:** 00901-1607
- **BUSINESS PHONE:** 703-963-7214

**MAIL ADDRESS:**
- **STREET 1:** 151 CALLE DE SAN FRANCISCO
- **STREET 2:** SUITE 200 PMB 1237
- **CITY:** SAN JUAN
- **STATE:** PR
- **ZIP:** 00901-1607

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| | |
|:---|:---|
| &nbsp;&nbsp;SECURITIES AND EXCHANGE COMMISSION | &nbsp;&nbsp;SECURITIES AND EXCHANGE COMMISSION |
| &nbsp;&nbsp;Washington, D.C. 20549 | &nbsp;&nbsp;Washington, D.C. 20549 |
| &nbsp;&nbsp;SCHEDULE 13G/A | &nbsp;&nbsp;SCHEDULE 13G/A |
| &nbsp;&nbsp;Under the Securities Exchange Act of 1934 | &nbsp;&nbsp;Under the Securities Exchange Act of 1934 |
| &nbsp;&nbsp;(Amendment No. 1)\* | &nbsp;&nbsp;(Amendment No. 1)\* |
| &nbsp;&nbsp; Cabaletta Bio, Inc. | &nbsp;&nbsp; Cabaletta Bio, Inc. |
| &nbsp;&nbsp;(Name of Issuer) | &nbsp;&nbsp;(Name of Issuer) |
| &nbsp;&nbsp; Common Stock, $0.00001 par value per share | &nbsp;&nbsp; Common Stock, $0.00001 par value per share |
| &nbsp;&nbsp;(Title of Class of Securities) | &nbsp;&nbsp;(Title of Class of Securities) |
| &nbsp;&nbsp; 12674W109 | &nbsp;&nbsp; 12674W109 |
| &nbsp;&nbsp;(CUSIP Number) | &nbsp;&nbsp;(CUSIP Number) |
| &nbsp;&nbsp; December 31, 2022 | &nbsp;&nbsp; December 31, 2022 |
| &nbsp;&nbsp;(Date of Event Which Requires Filing of this Statement) | &nbsp;&nbsp;(Date of Event Which Requires Filing of this Statement) |
| &nbsp;&nbsp;Check the appropriate box to designate the rule pursuant to which this Schedule is filed: | &nbsp;&nbsp;Check the appropriate box to designate the rule pursuant to which this Schedule is filed: |
| &nbsp;&nbsp;◻ | &nbsp;&nbsp;Rule 13d-1(b) |
| &nbsp;&nbsp;⌧ | &nbsp;&nbsp;Rule 13d-1(c) |
| &nbsp;&nbsp;◻ | &nbsp;&nbsp;Rule 13d-1(d) |
| &nbsp;&nbsp;(Page 1 of 7 Pages) | &nbsp;&nbsp;(Page 1 of 7 Pages) |

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______________________________

\*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("<u>Act</u>") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

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| CUSIP No. 12674W109 | 13G/A | Page **2 of 7 Pages** |

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|:---|:---|:---|:---|
| **1** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; NAME OF REPORTING PERSON<br>Lynx1 Capital Management LP | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; NAME OF REPORTING PERSON<br>Lynx1 Capital Management LP | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; NAME OF REPORTING PERSON<br>Lynx1 Capital Management LP |
| **2** | &nbsp;&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP | &nbsp;&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP | &nbsp;&nbsp; (a) ◻<br> (b) ◻ |
| **3** | &nbsp;&nbsp;SEC USE ONLY | &nbsp;&nbsp;SEC USE ONLY | &nbsp;&nbsp;SEC USE ONLY |
| **4** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; CITIZENSHIP OR PLACE OF ORGANIZATION<br> Delaware | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; CITIZENSHIP OR PLACE OF ORGANIZATION<br> Delaware | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; CITIZENSHIP OR PLACE OF ORGANIZATION<br> Delaware |
| &nbsp;&nbsp;NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON WITH | **5** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SOLE VOTING POWER<br> 0 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SOLE VOTING POWER<br> 0 |
| &nbsp;&nbsp;NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON WITH | **6** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SHARED VOTING POWER<br> 2,825,976 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SHARED VOTING POWER<br> 2,825,976 |
| &nbsp;&nbsp;NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON WITH | **7** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SOLE DISPOSITIVE POWER<br> 0 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SOLE DISPOSITIVE POWER<br> 0 |
| &nbsp;&nbsp;NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON WITH | **8** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SHARED DISPOSITIVE POWER<br> 2,825,976 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SHARED DISPOSITIVE POWER<br> 2,825,976 |
| **9** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br> 2,825,976 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br> 2,825,976 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br> 2,825,976 |
| **10** | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES | &nbsp;&nbsp;◻ |
| **11** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)<br> 9.7% | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)<br> 9.7% | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)<br> 9.7% |
| **12** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; TYPE OF REPORTING PERSON<br> PN | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; TYPE OF REPORTING PERSON<br> PN | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; TYPE OF REPORTING PERSON<br> PN |

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|:---|:---|:---|
| CUSIP No. 12674W109 | 13G/A | Page **3 of 7 Pages** |

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|:---|:---|:---|:---|
| **1** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; NAME OF REPORTING PERSON<br> Weston Nichols | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; NAME OF REPORTING PERSON<br> Weston Nichols | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; NAME OF REPORTING PERSON<br> Weston Nichols |
| **2** | &nbsp;&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP | &nbsp;&nbsp;CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP | &nbsp;&nbsp; (a) ◻<br> (b) ◻ |
| **3** | &nbsp;&nbsp;SEC USE ONLY | &nbsp;&nbsp;SEC USE ONLY | &nbsp;&nbsp;SEC USE ONLY |
| **4** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; CITIZENSHIP OR PLACE OF ORGANIZATION<br> United States of America | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; CITIZENSHIP OR PLACE OF ORGANIZATION<br> United States of America | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; CITIZENSHIP OR PLACE OF ORGANIZATION<br> United States of America |
| &nbsp;&nbsp;NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON WITH | **5** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SOLE VOTING POWER<br> 0 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SOLE VOTING POWER<br> 0 |
| &nbsp;&nbsp;NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON WITH | **6** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SHARED VOTING POWER<br> 2,825,976 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SHARED VOTING POWER<br> 2,825,976 |
| &nbsp;&nbsp;NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON WITH | **7** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SOLE DISPOSITIVE POWER<br> 0 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SOLE DISPOSITIVE POWER<br> 0 |
| &nbsp;&nbsp;NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON WITH | **8** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SHARED DISPOSITIVE POWER<br> 2,825,976 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; SHARED DISPOSITIVE POWER<br> 2,825,976 |
| **9** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br> 2,825,976 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br> 2,825,976 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br> 2,825,976 |
| **10** | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES | &nbsp;&nbsp;CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES | &nbsp;&nbsp;◻ |
| **11** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)<br> 9.7% | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)<br> 9.7% | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)<br> 9.7% |
| **12** | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; TYPE OF REPORTING PERSON<br> IN | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; TYPE OF REPORTING PERSON<br> IN | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; TYPE OF REPORTING PERSON<br> IN |

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|:---|:---|:---|
| CUSIP No. 12674W109 | 13G/A | Page **4 of 7 Pages** |

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|:---|:---|
| &nbsp;&nbsp;**Item 1(a).** | &nbsp;&nbsp;**Name of Issuer.** |
|  | &nbsp;&nbsp;Cabaletta Bio, Inc. (the "<u>Issuer</u>") |

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|:---|:---|
| &nbsp;&nbsp;**Item 1(b).** | &nbsp;&nbsp;**Address of Issuer's Principal Executive Offices.** |
|  | &nbsp;&nbsp; 2929 Arch Street, Suite 600<br> Philadelphia, PA 19104 |

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|:---|:---|
| &nbsp;&nbsp;**Item 2(a).** | &nbsp;&nbsp;**Name of Person Filing.** |
|  | &nbsp;&nbsp;This statement is filed by: |

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(i) Lynx1 Capital Management LP (the " <u>Investment Manager</u> "), a Delaware limited partnership, and the investment manager to Lynx1 Master Fund LP (the " <u>Lynx1 Fund</u> "),
 with respect to the shares of Common Stock (as defined in Item 2(d) below) directly held by the Lynx1 Fund; and

(ii) Mr. Weston Nichols (" <u>Mr. Nichols</u> "), the sole member of Lynx1 Capital Management GP LLC, the general partner of the Investment Manager, with respect to the shares of Common Stock directly held by the Lynx1 Fund.

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|:---|
| &nbsp;&nbsp;The foregoing persons are hereinafter sometimes collectively referred to as the "<u>Reporting Persons</u>." |
| &nbsp;&nbsp;The filing of this statement should not be construed as an admission that any of the foregoing persons or any Reporting Person is, for the purposes of Section 13 of the Act, the beneficial owner of the shares of Common Stock reported herein. |

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|:---|:---|
| &nbsp;&nbsp;**Item 2(b).** | &nbsp;&nbsp;**Address of Principal Business Office.** |
|  | &nbsp;&nbsp; Lynx1 Capital Management LP<br> 151 Calle de San Francisco<br> Suite 200, PMB 1237<br> San Juan, PR 00901-1607<br>Weston Nichols<br> c/o Lynx1 Capital Management LP<br> 151 Calle de San Francisco<br> Suite 200, PMB 1237<br> San Juan, PR 00901-1607 |
| &nbsp;&nbsp;**Item 2(c).** | &nbsp;&nbsp;**Place of Organization.** |
|  | &nbsp;&nbsp; Investment Manager – Delaware<br> Mr. Nichols – United States of America |

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| CUSIP No. 12674W109 | 13G/A | Page **5 of 7 Pages** |

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| &nbsp;&nbsp;**Item 2(d).** | &nbsp;&nbsp;**Title of Class of Securities.** |
|  | &nbsp;&nbsp;Common stock, $0.00001 par value per share (the "<u>Common Stock</u>") |

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|:---|:---|
| &nbsp;&nbsp;**Item 2(e).** | &nbsp;&nbsp;**CUSIP Number.** |
|  | &nbsp;&nbsp;12674W109 |

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|:---|:---|
| &nbsp;&nbsp;**Item 3.** | &nbsp;&nbsp;**If this Statement is Filed Pursuant to §§ 240.13d-1(b) or 240.13d-2(b), or (c), check whether the Person Filing is a:** |

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(a) ◻ Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);

(b) ◻ Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);

(c) ◻ Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);

(d) ◻ Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);

(e) ◻ An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);

(f) ◻ An employee benefit plan or endowment fund in accordance
 with § 240.13d-1(b)(1)(ii)(F);

(g) □ A parent holding company or control person in accordance
 with §240.13d-1(b)(1)(ii)(G);

(h) ◻ A savings association as defined in Section 3(b) of the Federal Deposit
 Insurance Act (12 U.S.C.1813);

(i) ◻ A church plan that is excluded from the definition of an investment company
 under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);

(j) ◻ A non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J);

(k) ◻ Group, in accordance with §240.13d-1(b)(1)(ii)(K).

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|:---|:---|:---|
| CUSIP No. 12674W109 | 13G/A | Page **6 of 7 Pages** |

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If filing as a non-U.S. institution in accordance with Rule 13d-1(b)(1)(ii)(J), please specify the type of institution:________________________________________

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|:---|:---|
| &nbsp;&nbsp;**Item 4.** | &nbsp;&nbsp;**Ownership.** |
|  | &nbsp;&nbsp; The information required by Items 4(a) – (c) is set forth in Rows (5) – (11) of the cover page for each Reporting Person hereto and is incorporated herein by reference for each Reporting Person.<br>The percentages set forth herein are calculated based upon 29,140,810 shares of Common Stock outstanding as reported in the Issuer's Prospectus filed pursuant to Rule 424(b)(5) with the Securities and Exchange Commission on December 8, 2022, after giving effect to the completion of the offering as described therein. |

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|:---|:---|
| &nbsp;&nbsp;**Item 5.** | &nbsp;&nbsp;**Ownership of Five Percent or Less of a Class.** |
|  | &nbsp;&nbsp;Not applicable. |

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|:---|:---|
| &nbsp;&nbsp;**Item 6.** | &nbsp;&nbsp;**Ownership of More Than Five Percent on Behalf of Another Person.** |
|  | &nbsp;&nbsp;The Lynx1 Fund has the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the shares of Common Stock reported herein. |

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|:---|:---|
| &nbsp;&nbsp;**Item 7.** | &nbsp;&nbsp;**Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.** |
|  | &nbsp;&nbsp;Not applicable. |

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|:---|:---|
| &nbsp;&nbsp;**Item 8.** | &nbsp;&nbsp;**Identification and Classification of Members of the Group.** |
|  | &nbsp;&nbsp;Not applicable. |

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|:---|:---|
| &nbsp;&nbsp;**Item 9.** | &nbsp;&nbsp;**Notice of Dissolution of Group.** |
|  | &nbsp;&nbsp;Not applicable. |

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|:---|:---|
| &nbsp;&nbsp;**Item 10.** | &nbsp;&nbsp;**Certification.** |
|  | &nbsp;&nbsp;By signing below each Reporting Person certifies that, to the best of his or its knowledge and belief, the securities referred to above were not acquired for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. |

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|:---|:---|:---|
| CUSIP No. 12674W109 | 13G/A | Page **7 of 7 Pages** |

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**<u>SIGNATURE</u>**

After reasonable inquiry and to the best of my knowledge and belief, each of the undersigned certifies that the information set forth in this statement is true, complete and correct.

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| | |
|:---|:---|
| &nbsp;&nbsp;Date: February 14, 2023 |  |
|  | &nbsp;&nbsp; Lynx1 capital management lp<br> By: Lynx1 Capital Management GP LLC, its general partner<br>|
|  | &nbsp;&nbsp;By: <u>/s/ Weston Nichols</u> |
|  | &nbsp;&nbsp;Name: Weston Nichols |
|  | &nbsp;&nbsp;Title: Sole Member |
|  | &nbsp;&nbsp;<u>/s/ Weston Nichols</u> |
|  | &nbsp;&nbsp;WESTON NICHOLS |

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