# EDGAR Filing Document

**Accession Number:** 0001835268
**File Stem:** 0001835268-26-000020
**Filing Date:** 2026-5
**Character Count:** 103293
**Document Hash:** 92cd5659be6083dc358a34185ce98ed3
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001835268-26-000020.hdr.sgml**: 20260512

**ACCESSION NUMBER**: 0001835268-26-000020

**CONFORMED SUBMISSION TYPE**: 10-Q

**PUBLIC DOCUMENT COUNT**: 61

**CONFORMED PERIOD OF REPORT**: 20260331

**FILED AS OF DATE**: 20260512

**DATE AS OF CHANGE**: 20260512

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Connect Biopharma Holdings Ltd
- **CENTRAL INDEX KEY:** 0001835268
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** E9
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 10-Q
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-40212
- **FILM NUMBER:** 26966104

**BUSINESS ADDRESS:**
- **STREET 1:** 3580 CARMEL MOUNTAIN ROAD, SUITE 200
- **CITY:** SAN DIEGO
- **STATE:** CA
- **ZIP:** 92130
- **BUSINESS PHONE:** 858-727-1040

**MAIL ADDRESS:**
- **STREET 1:** 3580 CARMEL MOUNTAIN ROAD, SUITE 200
- **CITY:** SAN DIEGO
- **STATE:** CA
- **ZIP:** 92130

?xml version='1.0' encoding='ASCII'? cntb-20260331

**[**TABLE OF CONTENTS**](#i46b71458e1224d37a858ff5acc38daea_7)**

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**WASHINGTON, D.C. 20549**

_______________________

**FORM 10-Q**

_______________________

⌧ **QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934**

**For the quarterly period ended March 31, 2026**

**or**

□ **TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934**

**For the transition period from _______ to ________**

**Commission File Number: 001-40212**

_______________________

**Connect Biopharma Holdings Limited**

*(Exact name of registrant as specified in its charter)*

_______________________

---

| | |
|:---|:---|
| **Cayman Islands** | **Not Applicable** |
| (State or other jurisdiction of incorporation or organization) | (I.R.S. Employer Identification No.) |
| **3580 Carmel Mountain Road, Suite 200** | |
| **San Diego, California** | **92130** |
| (Address of Principal Executive Offices) | (Zip Code) |

---

(Registrant's Telephone Number, Including Area Code): (877) 245-2787

_______________________

Securities registered pursuant to Section 12(b) of the Act:

---

| | | |
|:---|:---|:---|
| **Title of Each<br>Class** | **Trading Symbol** | **Name of Each Exchange on Which <br>Registered** |
| Ordinary Shares, par value $0.000174 per Share | CNTB | The Nasdaq Global Market |

---

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ⌧ No □

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ⌧ No □

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | □ | Accelerated filer | □ |
| Non-accelerated filer | ⌧ | Smaller reporting company | ⌧ |
|  | | Emerging growth company | ⌧ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. □

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Yes □&nbsp;&nbsp;&nbsp;&nbsp; No ⌧

As of April 30, 2026, there were 62,963,853 ordinary shares of the Company ($0.000174 par value) outstanding.

------

**[**TABLE OF CONTENTS**](#i46b71458e1224d37a858ff5acc38daea_7)**

**CONNECT BIOPHARMA HOLDINGS LIMITED**

**FORM 10-Q FOR THE THREE MONTHS ENDED MARCH 31, 2026**

**TABLE OF CONTENTS**

---

| | | |
|:---|:---|:---|
| **[PART I.](#i46b71458e1224d37a858ff5acc38daea_13)** | **[FINANCIAL INFORMATION](#i46b71458e1224d37a858ff5acc38daea_13)** | **Page** |
| [ITEM 1.](#i46b71458e1224d37a858ff5acc38daea_16) | [Condensed Consolidated Financial Statements (unaudited)](#i46b71458e1224d37a858ff5acc38daea_16) | [4](#i46b71458e1224d37a858ff5acc38daea_19) |
|  | [Condensed Consolidated Balance Sheets as of](#i46b71458e1224d37a858ff5acc38daea_19)[March 31, 2026](#i46b71458e1224d37a858ff5acc38daea_19)[and December 31, 202](#i46b71458e1224d37a858ff5acc38daea_19)[5](#i46b71458e1224d37a858ff5acc38daea_19)[(unaudited)](#i46b71458e1224d37a858ff5acc38daea_19) | [4](#i46b71458e1224d37a858ff5acc38daea_19) |
|  | [Condensed Consolidated Statements of Operations and Comprehensive Loss for the Three](#i46b71458e1224d37a858ff5acc38daea_22)[Months Ended](#i46b71458e1224d37a858ff5acc38daea_22)[March 31, 2026 and 2025](#i46b71458e1224d37a858ff5acc38daea_22)[(unaudited)](#i46b71458e1224d37a858ff5acc38daea_22) | [5](#i46b71458e1224d37a858ff5acc38daea_22) |
|  | [Condensed Consolidated Statements of Shareholders](#i46b71458e1224d37a858ff5acc38daea_25)['](#i46b71458e1224d37a858ff5acc38daea_25)[Equity for the Three](#i46b71458e1224d37a858ff5acc38daea_25)[Months Ended](#i46b71458e1224d37a858ff5acc38daea_25)[March 31, 202](#i46b71458e1224d37a858ff5acc38daea_25)[6 and 2025](#i46b71458e1224d37a858ff5acc38daea_25)[(unaudited)](#i46b71458e1224d37a858ff5acc38daea_25) | [6](#i46b71458e1224d37a858ff5acc38daea_25) |
|  | [Condensed Consolidated Statements of Cash Flows for the](#i46b71458e1224d37a858ff5acc38daea_31)[Three](#i46b71458e1224d37a858ff5acc38daea_31)[Months Ended](#i46b71458e1224d37a858ff5acc38daea_31)[March 31, 2026 and 2025](#i46b71458e1224d37a858ff5acc38daea_31)[(unaudited)](#i46b71458e1224d37a858ff5acc38daea_31) | [8](#i46b71458e1224d37a858ff5acc38daea_31) |
|  | [Notes to Unaudited Condensed Consolidated Financial Statements](#i46b71458e1224d37a858ff5acc38daea_34) | [9](#i46b71458e1224d37a858ff5acc38daea_34) |
| [ITEM 2.](#i46b71458e1224d37a858ff5acc38daea_76) | [Management's Discussion and Analysis of Financial Condition and Results of Operations](#i46b71458e1224d37a858ff5acc38daea_76) | [20](#i46b71458e1224d37a858ff5acc38daea_76) |
| [ITEM 3.](#i46b71458e1224d37a858ff5acc38daea_91) | [Quantitative and Qualitative Disclosures](#i46b71458e1224d37a858ff5acc38daea_91)[A](#i46b71458e1224d37a858ff5acc38daea_91)[bout Market Risk](#i46b71458e1224d37a858ff5acc38daea_91) | [24](#i46b71458e1224d37a858ff5acc38daea_91) |
| [ITEM 4.](#i46b71458e1224d37a858ff5acc38daea_94) | [Controls and Procedures](#i46b71458e1224d37a858ff5acc38daea_94) | [24](#i46b71458e1224d37a858ff5acc38daea_94) |
| **[PART II.](#i46b71458e1224d37a858ff5acc38daea_97)** | **[OTHER INFORMATION](#i46b71458e1224d37a858ff5acc38daea_97)** |  |
| [ITEM 1.](#i46b71458e1224d37a858ff5acc38daea_100) | [Legal Proceedings](#i46b71458e1224d37a858ff5acc38daea_100) | [24](#i46b71458e1224d37a858ff5acc38daea_100) |
| [ITEM 1A.](#i46b71458e1224d37a858ff5acc38daea_103) | [Risk Factors](#i46b71458e1224d37a858ff5acc38daea_103) | [24](#i46b71458e1224d37a858ff5acc38daea_103) |
| [ITEM 2.](#i46b71458e1224d37a858ff5acc38daea_76) | [Unregistered Sales of Equity Securities and Use of Proceeds](#i46b71458e1224d37a858ff5acc38daea_106) | [24](#i46b71458e1224d37a858ff5acc38daea_106) |
| [ITEM 3.](#i46b71458e1224d37a858ff5acc38daea_91) | [Defaults](#i46b71458e1224d37a858ff5acc38daea_109)[U](#i46b71458e1224d37a858ff5acc38daea_109)[pon Senior Securities](#i46b71458e1224d37a858ff5acc38daea_109) | [25](#i46b71458e1224d37a858ff5acc38daea_109) |
| [ITEM 4.](#i46b71458e1224d37a858ff5acc38daea_94) | [Mine Safety Disclosures](#i46b71458e1224d37a858ff5acc38daea_112) | [25](#i46b71458e1224d37a858ff5acc38daea_112) |
| [ITEM 5.](#i46b71458e1224d37a858ff5acc38daea_115) | [Other Information](#i46b71458e1224d37a858ff5acc38daea_115) | [25](#i46b71458e1224d37a858ff5acc38daea_115) |
| [ITEM 6.](#i46b71458e1224d37a858ff5acc38daea_118) | [Exhibits](#i46b71458e1224d37a858ff5acc38daea_118) | [26](#i46b71458e1224d37a858ff5acc38daea_118) |
|  | [SIGNATURES](#i46b71458e1224d37a858ff5acc38daea_121) | [27](#i46b71458e1224d37a858ff5acc38daea_121) |

---

------

**[**TABLE OF CONTENTS**](#i46b71458e1224d37a858ff5acc38daea_7)**

**EXPLANATORY NOTE**

Connect Biopharma Holdings Limited (the "Company"), an exempted company incorporated under the laws of the Cayman Islands, qualifies as a "foreign private issuer," as defined in Rule 3b-4 under the Securities Exchange Act of 1934, as amended (the "Exchange Act") in the United States (the "U.S."). The Company has voluntarily elected to file annual reports on Form 10-K, quarterly reports on Form 10-Q and current reports on Form 8-K with the U.S. Securities and Exchange Commission instead of filing on the reporting forms available to foreign private issuers.

Although the Company has voluntarily elected to file annual, periodic and current reports on U.S. domestic issuer forms, the Company intends to maintain its status as a foreign private issuer. Accordingly, as a foreign private issuer, the Company remains exempt from the U.S. federal proxy rules pursuant to Section 14 of the Exchange Act and Regulations 14A and 14C thereunder, and Regulation FD. On December 18, 2025, as part of the National Defense Authorization Act for Fiscal Year 2026, the Holding Foreign Insiders Accountable Act (the "HFIAA") was signed into law. The HFIAA amended Section 16(a) of the Exchange Act to require directors and officers of foreign private issuers, but not its principal shareholders, to comply with the insider reporting requirements set forth in Section 16(a) of the Exchange Act, beginning March 18, 2026. The Company's officers, directors, and principal shareholders are not subject to the short-swing profit recovery provisions contained in Section 16(b) of the Exchange Act.

------

**[**TABLE OF CONTENTS**](#i46b71458e1224d37a858ff5acc38daea_7)**

**PART I—FINANCIAL INFORMATION**

**Item 1. Condensed Consolidated Financial Statements**

**CONNECT BIOPHARMA HOLDINGS LIMITED**

**CONDENSED CONSOLIDATED BALANCE SHEETS**

**(Unaudited)**

**(in thousands, except par value and share amounts)**

---

| | | |
|:---|:---|:---|
| | **March 31, 2026** | **December 31, 2025** |
| **ASSETS** | | |
| Current assets: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Cash and cash equivalents | $46034 | $38345 |
| &nbsp;&nbsp;&nbsp;&nbsp;Short-term investments |  | 5997 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accounts receivable, net |  | 13 |
| &nbsp;&nbsp;&nbsp;&nbsp;Prepaid expenses and other current assets | 8986 | 6574 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total current assets | 55020 | 50929 |
| Property and equipment, net | 3704 | 3808 |
| Right-of-use lease assets, net | 653 | 647 |
| Intangible assets, net | 43 | 45 |
| Other assets | 646 | 646 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total assets | $60066 | $56075 |
| **LIABILITIES AND SHAREHOLDERS' EQUITY** |  |  |
| Current liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Accounts payable | $4306 | $1964 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accrued liabilities | 12333 | 11160 |
| &nbsp;&nbsp;&nbsp;&nbsp;Contract liabilities |  | 167 |
| &nbsp;&nbsp;&nbsp;&nbsp;Current lease liabilities | 406 | 322 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total current liabilities | 17045 | 13613 |
| Non-current lease liabilities | 287 | 368 |
| Other non-current liabilities | 111 | 114 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total liabilities | 17443 | 14095 |
| Commitments and contingencies (see Note 7) |  |  |
| Shareholders' equity: |  |  |
| Ordinary shares, $0.000174 par value; 400,000,000 shares authorized; 62,711,690 and 56,442,308 shares issued and outstanding at March 31, 2026 and December 31, 2025, respectively | 11 | 10 |
| &nbsp;&nbsp;&nbsp;&nbsp;Additional paid-in capital | 464088 | 444176 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accumulated other comprehensive loss | (1063) | (1191) |
| &nbsp;&nbsp;&nbsp;&nbsp;Treasury shares | (180) | (180) |
| &nbsp;&nbsp;&nbsp;&nbsp;Accumulated deficit | (420233) | (400835) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total shareholders' equity | 42623 | 41980 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total liabilities and shareholders' equity | $60066 | $56075 |

---

*See accompanying notes.*

------

**[**TABLE OF CONTENTS**](#i46b71458e1224d37a858ff5acc38daea_7)**

**CONNECT BIOPHARMA HOLDINGS LIMITED**

**CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND** 

**COMPREHENSIVE LOSS**

**(Unaudited)**

**(in thousands, except per share amounts)**

---

| | | |
|:---|:---|:---|
| | **Three Months Ended March 31,** | **Three Months Ended March 31,** |
| | **2026** | **2025** |
| License and collaboration revenues | $169 | $— |
| Operating expenses: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Research and development expense | 15030 | 6633 |
| &nbsp;&nbsp;&nbsp;&nbsp;General and administrative expense | 4746 | 4814 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total operating expenses | 19776 | 11447 |
| Loss from operations | (19607) | (11447) |
| Other income, net: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Interest income | 260 | 720 |
| &nbsp;&nbsp;&nbsp;&nbsp;Other income (expense) | (3) | 509 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total other income, net | 257 | 1229 |
| Net loss before income tax | (19350) | (10218) |
| Income tax expense | 48 | 54 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net loss | $(19398) | $(10272) |
| Other comprehensive loss: |  |  |
| Foreign currency translation adjustments | 132 | 62 |
| Unrealized losses on available-for-sale investments | (4) | (1) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Comprehensive loss | $(19270) | $(10211) |
| Basic and diluted net loss per ordinary share | $(0.34) | $(0.19) |
| Weighted-average ordinary shares outstanding, basic and diluted | 56545 | 55352 |

---

*See accompanying notes.*

------

**[**TABLE OF CONTENTS**](#i46b71458e1224d37a858ff5acc38daea_7)**

**CONNECT BIOPHARMA HOLDINGS LIMITED**

**CONDENSED CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY**

**(Unaudited)**

**(in thousands)**

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| | **Ordinary Shares** | **Ordinary Shares** | **Additional <br>Paid-In <br>Capital** | **Accumulated <br>Other <br>Comprehensive <br>Loss** | | **Accumulated<br>Deficit** | **Total <br>Shareholders' <br>Equity** |
| | **Shares** | **Amount** | **Additional <br>Paid-In <br>Capital** | **Accumulated <br>Other <br>Comprehensive <br>Loss** | **Treasury**<br>**Shares** | **Accumulated<br>Deficit** | **Total <br>Shareholders' <br>Equity** |
| Balance, December 31, 2025 | 56442 | $10 | $444176 | $(1191) | $(180) | $(400835) | $41980 |
| Issuance of ordinary shares in a private placement, net of issuance costs | 6130 | 1 | 18576 |  |  |  | 18577 |
| Issuance of ordinary shares under the Stock Incentive Plan | 140 |  | 137 |  |  |  | 137 |
| Share-based compensation expense |  |  | 1199 |  |  |  | 1199 |
| Net loss |  |  |  |  |  | (19398) | (19398) |
| Net unrealized losses on available-for-sale investments |  |  |  | (4) |  |  | (4) |
| Foreign currency translation adjustments |  |  |  | 132 |  |  | 132 |
| Balance, March 31, 2026 | 62712 | $11 | $464088 | $(1063) | $(180) | $(420233) | $42623 |

---

*See accompanying notes.*

------

**[**TABLE OF CONTENTS**](#i46b71458e1224d37a858ff5acc38daea_7)**

**CONNECT BIOPHARMA HOLDINGS LIMITED**

**CONDENSED CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY**

**(Unaudited)**

**(in thousands)**

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| | **Ordinary Shares** | **Ordinary Shares** | **Additional <br>Paid-In <br>Capital** | **Accumulated <br>Other <br>Comprehensive Loss** | | **Accumulated <br>Deficit** | **Total <br>Shareholders' <br>Equity** |
| | **Shares** | **Amount** | **Additional <br>Paid-In <br>Capital** | **Accumulated <br>Other <br>Comprehensive Loss** | **Treasury**<br>**Shares** | **Accumulated <br>Deficit** | **Total <br>Shareholders' <br>Equity** |
| Balance, December 31, 2024 | 55349 | $10 | $439357 | $(1666) | $(180) | $(345355) | $92166 |
| Issuance of ordinary shares under the Stock Incentive Plan | 3 |  | 2 |  |  |  | 2 |
| Share-based compensation expense |  |  | 942 |  |  |  | 942 |
| Net loss |  |  |  |  |  | (10272) | (10272) |
| Net unrealized losses on available-for-sale investments |  |  |  | (1) |  |  | (1) |
| Foreign currency translation adjustments |  |  |  | 62 |  |  | 62 |
| Balance, March 31, 2025 | 55352 | $10 | $440301 | $(1605) | $(180) | $(355627) | $82899 |

---

*See accompanying notes.*

------

**[**TABLE OF CONTENTS**](#i46b71458e1224d37a858ff5acc38daea_7)**

**CONNECT BIOPHARMA HOLDINGS LIMITED**

**CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS**

**(Unaudited)**

**(in thousands)**

---

| | | |
|:---|:---|:---|
| | **Three Months Ended March 31,** | **Three Months Ended March 31,** |
| | **2026** | **2025** |
| **Operating activities:** |  |  |
| Net loss | $(19398) | $(10272) |
| Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Share-based compensation expense | 1199 | 942 |
| &nbsp;&nbsp;&nbsp;&nbsp;Depreciation and amortization | 164 | 173 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accretion of discounts on available-for-sale investments | (7) | (249) |
| &nbsp;&nbsp;&nbsp;&nbsp;Loss on disposal of property and equipment |  | 34 |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in operating assets and liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Accounts receivable, net | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;13 | 781 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Prepaid expenses and other current assets | 257 | (1288) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Other non-current assets | 2 | (9) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Accounts payable | 2342 | 475 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Accrued liabilities | (404) | (564) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Contract liabilities | (167) |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Operating lease liabilities | (3) | 23 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Other non-current liabilities | (3) | (5) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net cash used in operating activities | (16005) | (9959) |
| **Investing activities:** |  |  |
| Purchases of short-term investments |  | (22562) |
| Proceeds from maturities and sales of short-term investments | 6000 | 2000 |
| Purchases of property and equipment |  | (81) |
| Proceeds from sale of property and equipment |  | 2 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net cash provided by (used in) investing activities | 6000 | (20641) |
| **Financing activities:** |  |  |
| Proceeds from private placement | 17485 |  |
| Proceeds from issuances of ordinary shares under the Stock Incentive Plan | 137 | 2 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net cash provided by financing activities | 17622 | 2 |
| Effect of exchange rate changes on cash and cash equivalents | 72 | 75 |
| Net increase (decrease) in cash and cash equivalents | 7689 | (30523) |
| Cash and cash equivalents at beginning of year | 38345 | 78232 |
| Cash and cash equivalents at end of year | $46034 | $47709 |
| **Non-cash financing activities:** |  |  |
| Subscription receivable | $2669 | $— |
| Private placement issuance costs, accrued but not paid | $1577 | $— |

---

*See accompanying notes.*

------

**[**TABLE OF CONTENTS**](#i46b71458e1224d37a858ff5acc38daea_7)**

**CONNECT BIOPHARMA HOLDINGS LIMITED**

**NOTES TO UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS**

**1. Organization and Business**

Connect Biopharma Holdings Limited ("Connect," "Connect Biopharma," the "Company," "we," "us," "our" and similar terms refer to Connect Biopharma Holdings Limited, together with its subsidiaries), headquartered in San Diego, California, is a clinical-stage biopharmaceutical company dedicated to transforming care for asthma and chronic obstructive pulmonary disease ("COPD"). The Company is advancing rademikibart, a next-generation, potentially best-in-class antibody designed to target interleukin-4-receptor alpha ("IL-4Rα").

Connect Biopharma was incorporated in November 2015 in the Cayman Islands as an exempted company with limited liability. The Company completed its initial public offering in March 2021, and its ordinary shares, par value $0.000174 per share ("Ordinary Shares"), are listed on the Nasdaq Global Market under the symbol "CNTB".

**2. Liquidity and Going Concern**

As of March 31, 2026, the Company had cash and cash equivalents of $46.0 million. Based on its current operating plan and projections, management believes that the Company's cash and cash equivalents will be sufficient to meet the Company's anticipated cash requirements for a period of at least one year from the date this Quarterly Report on Form 10-Q is filed with the U.S. Securities and Exchange Commission (the "SEC").

**3. Basis of Presentation and Significant Accounting Policies**

***Basis of Presentation***

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the U.S. ("U.S. GAAP") for interim financial information and the applicable rules and regulations of the SEC for interim reporting. Accordingly, since they are interim statements, they do not include all of the information and disclosures required by U.S. GAAP for complete financial statements. In the opinion of management, all adjustments (consisting of normal recurring accruals) considered necessary for a fair statement have been included. Operating results for the three months ended March 31, 2026 are not necessarily indicative of the results that may be expected for other quarters or the year ending December 31, 2026. The condensed consolidated balance sheet as of December 31, 2025 has been derived from the audited financial statements as of that date. These unaudited condensed consolidated financial statements and the notes thereto should be read in conjunction with the audited financial statements included in our Annual Report on Form 10-K for the year ended December 31, 2025, which was filed with the SEC on March 31, 2026 ("2025 Annual Report").

***Principles of Consolidation***

The accompanying condensed consolidated financial statements include the accounts of the Company and its direct and indirect subsidiaries. All intercompany accounts and transactions have been eliminated in consolidation. The following are the Company's subsidiaries:

*Directly Held*

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Connect Biopharma HongKong Limited ("Connect HK")

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*Indirectly Held*

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Connect Biopharm LLC

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Connect Biopharma Australia PTY LTD

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Suzhou Connect Biopharma Co., Ltd. ("Connect SZ")

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Connect Biopharma (Beijing) Co., Ltd.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Connect Biopharma (Shanghai) Co., Ltd.

***Use of Estimates***

The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in the financial statements and disclosures made in the accompanying notes to the financial statements. Our significant accounting policies that involve significant judgment and estimates include revenue recognition, investments, accrued research and development expenses, income taxes and share-based compensation. Actual results could differ materially from those estimates.

***Fair Value of Financial Instruments***

A company may elect to use fair value to measure financial instruments. If the use of fair value is elected, any upfront costs and fees related to the item such as debt issuance costs must be recognized in earnings and cannot be deferred. The fair value election is irrevocable and generally made on an instrument-by-instrument basis, even if a company has similar instruments that it elects not to measure based on fair value. Unrealized gains and losses on existing items for which fair value has been elected are reported as a cumulative adjustment to beginning retained earnings and any changes in fair value are recognized in earnings. We have elected to not apply the fair value option to our financial assets and liabilities.

Cash and cash equivalents, receivables, prepaid expenses, other assets, accounts payable and accrued expenses, are carried at cost, which is considered to be representative of their respective fair values because of the short-term maturity of these instruments. Available-for-sale investment securities are carried at fair value.

Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs. The Financial Accounting Standards Board ("FASB") Accounting Standards Codification ("ASC") Topic 820, *Fair Value Measurements & Disclosures,* establishes a fair value hierarchy which prioritizes the inputs used in measuring fair value as follows:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Level 1—Observable inputs such as quoted prices in active markets for identical assets or liabilities.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Level 2—Inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

***Accounts Receivable, Net***

Accounts receivable are recorded at the invoice amount, net of an allowance for credit losses. The allowance for credit losses reflects accounts receivable balances that are believed to be uncollectible. In estimating the allowance for credit losses, we consider: (1) our historical experience with collections and write-offs; (2) the credit quality of our customers and any recent or anticipated changes thereto; (3) the outstanding balances and past due amounts from our customers; and (4) reasonable and supportable forecast of economic conditions expected to exist throughout the contractual term of the receivable.

As of March 31, 2026 and December 31, 2025, we determined that an allowance for credit losses was not required. For the three months ended March 31, 2026 and 2025, we did not have any material write-offs of accounts receivable balances.

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***Net Loss per Share***

Basic net loss per share is calculated by dividing the net loss by the weighted-average number of ordinary shares outstanding for the period. Diluted net loss per share is computed by dividing the net loss by the weighted-average number of ordinary shares and ordinary share equivalents outstanding for the period determined using the treasury share method. For purposes of this calculation, stock options and employee share purchase rights are considered to be ordinary share equivalents and are included in the calculation of diluted net loss per share only when their effect is dilutive.

Because we incurred a net loss for the three months ended March 31, 2026 and 2025, the following ordinary share equivalents were not included in the computation of net loss per share because their effect would be anti-dilutive (in thousands):

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| | | |
|:---|:---|:---|
| | **March 31,** | **March 31,** |
| | **2026** | **2025** |
| Stock options outstanding | 15168 | 13319 |
| Employee stock purchase plan rights | 600 | 486 |
|  | 15768 | 13805 |

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***Significant Accounting Policies***

A complete description of our significant accounting policies are disclosed in Note 3 in the 2025 Annual Report.

***Recent Accounting Pronouncements***

*Adopted*

In September 2025, the FASB issued Accounting Standards Update ("ASU") No. 2025-05, *Financial Instruments - Credit Losses (Topic 326): Measurement of Credit Losses for Accounts Receivable and Contract Assets* ("ASU 2025-05"). ASU 2025-05 provides all entities with a practical expedient when estimating expected credit losses for current accounts receivable and current contract assets arising from transactions accounted for under ASC Topic 606, *Revenue Recognition* ("Topic 606"). Under ASU 2025-05, an entity is required to disclose whether it has elected to use the practical expedient. An entity that makes the accounting policy election is required to disclose the date through which subsequent cash collection are evaluated. ASU 2025-05 is effective for annual reporting periods beginning after December 15, 2025, and interim reporting periods within those annual reporting periods. On January 1, 2026, we adopted the provisions of ASU 2025-05 on a prospective basis and elected to apply the practical expedient for current accounts receivables and contract assets arising from transactions under Topic 606. The adoption of ASU 2025-05 did not have a material impact on our results of operations, financial condition or related disclosures.

*Not Yet Adopted*

In November 2024, the FASB issued ASU 2024-03, *Income Statement - Reporting Comprehensive Income - Expense Disaggregation Disclosures (Subtopic 220-40)* ("ASU 2024-03"). ASU 2024-03 requires that public business entities disclose additional information about specific expense categories in the notes to financial statements at interim and annual reporting periods. The prescribed categories include purchases of inventory, employee compensation, depreciation, intangible asset amortization, and depletion. ASU 2024-03 may be applied either prospectively or retrospectively and is effective for annual periods beginning after December 15, 2026 and interim periods beginning after December 15, 2027, with early adoption permitted. We are currently evaluating the impact of ASU 2024-03 on our disclosures.

In December 2025, the FASB issued ASU 2025-10, *Government Grants (Topic 832): Accounting for Government Grants Received by Business Entities* ("ASU 2025-10"). ASU 2025-10 establishes the accounting for government grants received by business entities, including guidance for (1) a grant related to an asset and (2) a grant related to income. The provisions of ASU 2025-10 can be applied on either a modified prospective or modified retrospective approach. The amendments in ASU 2025-10 are effective for annual reporting periods beginning after December 15, 2028, and interim reporting periods within those annual periods. Early adoption is permitted in both interim and annual reporting periods in which financial statements have not yet been issued or made available for issuance. We are currently evaluating the impact of ASU 2025-10 on our condensed consolidated financial statements and related disclosures.

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**4. Fair Value Measurements**

The Company measures cash, cash equivalents and short-term investments at fair value on a recurring basis. The fair values of such assets were as follows (in thousands):

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| | | | | |
|:---|:---|:---|:---|:---|
| | **Fair Value Measurements at Reporting Date Using** | **Fair Value Measurements at Reporting Date Using** | **Fair Value Measurements at Reporting Date Using** | **Fair Value Measurements at Reporting Date Using** |
| | **Balance at March 31, 2026** | **Quoted Prices in <br>Active Markets for <br>Identical Assets<br>(Level 1)** | **Significant Other <br>Observable Inputs <br>(Level 2)** | **Significant <br>Unobservable Inputs <br>(Level 3)** |
| Money market funds | $19604 | $19604 | $— | $— |
| U.S. commercial paper | 15923 |  | 15923 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total | $35527 | $19604 | $15923 | $— |

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| | | | | |
|:---|:---|:---|:---|:---|
| | **Fair Value Measurements at Reporting Date Using** | **Fair Value Measurements at Reporting Date Using** | **Fair Value Measurements at Reporting Date Using** | **Fair Value Measurements at Reporting Date Using** |
| | **Balance at December 31, 2025** | **Quoted Prices in <br>Active Markets for <br>Identical Assets <br>(Level 1)** | **Significant Other <br>Observable Inputs <br>(Level 2)** | **Significant <br>Unobservable Inputs <br>(Level 3)** |
| Money market funds | $8531 | $8531 | $— | $— |
| U.S. treasury bills | 3997 | 3997 |  |  |
| U.S. government agency obligations | 3001 |  | 3001 |  |
| U.S. corporate debt securities | 1001 |  | 1001 |  |
| U.S. commercial paper | 10973 |  | 10973 |  |
| Foreign commercial paper | 8458 |  | 8458 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total | $35961 | $12528 | $23433 | $— |

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We have not transferred any investment securities between the three levels of the fair value hierarchy.

As of March 31, 2026, cash equivalents included $15.9 million of available-for-sale securities with contractual maturities of three months or less. As of December 31, 2025, cash equivalents included $21.4 million of available-for-sale securities with contractual maturities of three months or less and short-term investments included $6.0 million of available-for-sale securities with contractual maturities of three months to one year. The money market funds as of March 31, 2026 and December 31, 2025 are included in cash and cash equivalents on the unaudited condensed consolidated balance sheets.

The Company's cash equivalents and short-term investment securities are classified within the fair value hierarchy as defined by authoritative guidance. The Company's investment securities classified as Level 1 are valued using quoted market prices. The Company obtains the fair value of its Level 2 financial instruments from third-party pricing services. The pricing services utilize industry standard valuation models whereby all significant inputs, including benchmark yields, reported trades, broker/dealer quotes, issuer spreads, bids, offers, or other market-related data, are observable. The Company validates the prices provided by the third-party pricing services by reviewing their pricing methods and matrices and obtaining market values from other pricing sources. After completing the validation procedures, the Company did not adjust or override any fair value measurements provided by these pricing services as of March 31, 2026 or December 31, 2025. The Company does not have any investments classified as Level 3.

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**5. Balance Sheet Details**

***Available-for-Sale Investments***

The following is a summary of our available-for-sale investments (in thousands):

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| | | | | |
|:---|:---|:---|:---|:---|
| | **March 31, 2026** | **March 31, 2026** | **March 31, 2026** | **March 31, 2026** |
| | **Amortized Cost** | **Gross Unrealized <br>Gains** | **Gross Unrealized <br>Losses** | **Estimated Fair <br>Value** |
| U.S. commercial paper | $15928 | $— | $(5) | $15923 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total | $15928 | $— | $(5) | $15923 |

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| | | | | |
|:---|:---|:---|:---|:---|
| | **December 31, 2025** | **December 31, 2025** | **December 31, 2025** | **December 31, 2025** |
| | **Amortized Cost** | **Gross Unrealized <br>Gains** | **Gross Unrealized <br>Losses** | **Estimated Fair <br>Value** |
| U.S. treasury bills | $3995 | $2 | $— | $3997 |
| U.S. government agency obligations | 3002 |  | (1) | 3001 |
| U.S. corporate debt securities | 1000 | 1 |  | 1001 |
| U.S. commercial paper | 10974 |  | (1) | 10973 |
| Foreign commercial paper | 8460 |  | (2) | 8458 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total | $27431 | $3 | $(4) | $27430 |

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At each reporting date, the Company performs an evaluation of impairment to determine if any unrealized losses are the result of credit losses. Impairment is assessed at the individual security level. Factors considered in determining whether a loss resulted from a credit loss or other factors include the Company's intent and ability to hold the investment until the recovery of its amortized cost basis, the extent to which the fair value is less than the amortized cost basis, the length of time and extent to which fair value has been less than the cost basis, the financial condition of the issuer, any historical failure of the issuer to make scheduled interest or principal payments, any changes to the rating of the security by a rating agency, any adverse legal or regulatory events affecting the issuer or issuer's industry, and any significant deterioration in economic conditions.

The Company does not intend to sell the investment in unrealized loss position and it is unlikely that the Company will be required to sell the investment before the recovery of its amortized cost basis. Based on its evaluation, the Company determined its credit losses related to its available-for-sale securities were immaterial at March 31, 2026 and December 31, 2025.

The amortized cost of debt securities is adjusted for amortization of premiums and accretion of discounts to maturity. The Company regularly monitors and evaluates the realizable value of its available-for-sale investment securities. The Company did not recognize any impairment losses for the three months ended March 31, 2026 or 2025.

Unrealized gains and losses associated with the Company's investments are reported in accumulated other comprehensive loss. For the three months ended March 31, 2026 and 2025, the Company recorded $4,000 and $1,000, respectively, in net unrealized losses associated with its available-for-sale investments.

Realized gains and losses associated with its investments, if any, are reported in the statements of operations and comprehensive loss. The Company did not recognize any realized gains or losses during the three months ended March 31, 2026 or 2025.

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***Prepaid Expenses and Other Current Assets***

Prepaid expenses and other current assets consist of the following (in thousands):

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| | | |
|:---|:---|:---|
| | **March 31, 2026** | **December 31, 2025** |
| Prepaid clinical and manufacturing expenses | $5523 | $5825 |
| Subscription receivable | 2669 |  |
| Prepaid insurance | 26 | 329 |
| Prepaid taxes | 266 | 243 |
| Interest receivables | 32 | 148 |
| Other prepaid expenses and current assets | 470 | 29 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total prepaid expenses and other current assets | $8986 | $6574 |

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On April 1, 2026, the Company received the funds related to the outstanding subscription receivable.

***Accrued Liabilities***

Accrued liabilities consist of the following (in thousands):

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| | | |
|:---|:---|:---|
| | **March 31, 2026** | **December 31, 2025** |
| Accrued clinical, manufacturing and professional expense | $10685 | $8086 |
| Accrued compensation and benefits | 1424 | 2914 |
| Other accrued expenses | 224 | 160 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total accrued liabilities | $12333 | $11160 |

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**6. License and Collaboration Agreement**

**Simcere License Agreement**

On November 21, 2023 (the "Effective Date"), Connect HK and Connect SZ ("Licensor") entered into an exclusive license and collaboration agreement (the "License Agreement") with Simcere Pharmaceutical Co., Ltd. ("Simcere" or "Licensee"), a subsidiary of Simcere Pharmaceutical Group Ltd., to develop and commercialize rademikibart in Greater China.

Simcere has been granted exclusive rights to develop, manufacture, and commercialize rademikibart for all indications in Greater China, including mainland China, Hong Kong, Macau, and Taiwan (the "Territory"), while Connect retains rights in all other markets. Under the License Agreement, Connect was required to complete all of rademikibart's ongoing clinical trials and related analysis in the Territory in atopic dermatitis ("AD"), while the Licensee is responsible for rademikibart's new drug application for AD in China and will also conduct and be responsible for the costs of all future clinical studies in all additional disease indications for rademikibart in Greater China.

As consideration for the rights granted to Simcere under the License Agreement, Simcere paid the Licensor a non-refundable, non-creditable up-front fee of approximately $21 million. Simcere is also required to make milestone payments to the Licensor upon the achievement of certain development, regulatory and commercial milestones ("Milestones"), initially totaling up to $123 million. In 2024, we received approximately $5 million in Milestone payments from Simcere for the achievement of certain development Milestones. In 2025, one time-based Milestone in the amount of approximately $8 million lapsed because it was not achieved by the deadline set forth in the License Agreement. Accordingly, as of March 31, 2026, we are eligible to receive remaining Milestone payments up to an aggregate amount of approximately $110 million. The achievement of these Milestones is dependent upon the timing and success of future development, regulatory and commercial activities to be completed by Simcere. Simcere is also required to make payments for cost reimbursements related to certain development activities, including supply of material for clinical development. The License Agreement additionally provides that Simcere is obligated to pay Licensor royalties at tiered percentage rates up to low double-digit percentages on net sales of the licensed product in the Territory.

The term of the License Agreement is coterminous with the period up to which sales-based royalty payments shall be made, which is approximately 12 years after commercialization of the licensed compound. After this period, the license is considered fully paid and Simcere can continue to exploit the rights in the license in the Territory.

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**Revenue Recognition**

The Company evaluated the License Agreement which provides Simcere with the right to use the Company's intellectual property in the Territory. The Company concluded that the License Agreement was subject to Topic 606 because the Company viewed the License Agreement as a contract with a customer as the activities were central to its business operations. As such, the Company assessed the terms of the License Agreement and identified four performance obligations for the license to research, develop, manufacture and commercialize rademikibart in the Territory. The four performance obligations identified include: (i) transfer of the intellectual property and know-how; (ii) transfer of the current manufacturing process; (iii) development and transfer of a new manufacturing process; and (iv) completion of certain rademikibart development services.

At inception of each arrangement that includes milestone payments, the Company evaluates where the milestones are considered probable of being reached. If it is probable that a significant revenue reversal would not occur, the associated milestone value is included in the transaction price. At the Effective Date, the Company determined the transaction price to be $25 million, which is comprised of (i) a $21 million upfront payment for the grant of license to the Licensee and (ii) $4 million of cost reimbursement upon delivery of certain clinical trial reports. All other milestones are considered to be constrained at the Effective Date because these milestones are not within the control of the Company and therefore these milestones are not included in the transaction price.

When an intellectual property license is determined to be a predominant promise in the arrangement, sales-based milestone payments and royalties are recognized at the later of when the associated performance obligation has been satisfied or when the sales occur. For cost reimbursements related to the supply of material for clinical development, the Company recognizes revenue when Simcere obtains control of the goods. For the three months ended March 31, 2026, the Company recognized $169,000 in revenue under the License Agreement related to the upfront license fee. No revenue was recognized for the three months ended March 31, 2025.

*Allocation of the Transaction Price*

The transaction price is generally allocated to the identified performance obligations based on the relative stand-alone selling price estimated for each distinct performance obligation. However the Company has allocated certain regulatory and development milestone payments only to certain specific performance obligation(s) where the terms of such payments relate specifically to the Company's efforts to satisfy the respective performance obligation, and provided that such allocation is consistent with the objective that transaction price is allocated to each performance obligation in order to reflect the consideration to which the Company expects to be entitled to receive in exchange for satisfying those performance obligations. The Company allocated the $25.0 million transaction price based on relative stand-alone selling prices of each performance obligation as $23.8 million for the license, $0.1 million for the transfer of the current manufacturing process, $0.2 million for development and transfer of a new manufacturing process, and $0.9 million for completion of certain rademikibart development services. The Company developed the estimated stand-alone selling price for the license using a discounted cash flows model, which is an income approach. In estimating the stand-alone selling price for each performance obligation, the Company developed assumptions that require judgment and included forecasted revenues, expected development timelines, discount rates, probabilities of technical and regulatory success and costs for manufacturing clinical supplies.

The Company utilizes judgment to assess when control of the goods and services transfers to Simcere, to determine whether the performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purposes of recognizing revenue. When recognizing revenue over time, the Company evaluates the measure of progress each reporting period and, if necessary, adjusts the progress of performance and related revenue recognition.

The Company expects to recognize the transaction price, at a point in time or over the expected performance period of each respective performance obligation. The Company began recognizing revenue from the License Agreement once the Company had substantially completed the transfer of the intellectual property and know-how to Simcere. The revenue associated with the transfer of the intellectual property and know-how and transfer of the current manufacturing process were recognized at a point in time upon successful completion of each obligation during 2024. The Company recognized the revenue associated with the transfer of a new manufacturing process at a point in time upon successful completion of the obligation in the first quarter of 2026. For the performance obligation to complete certain development services, the Company recognized the transaction price over the expected performance period using an input method. To measure the progress of this obligation, the Company used the cost-to-cost basis approach to estimate the percentage of completion as this method provides the most faithful depiction of the Company's performance in transferring control of the services

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promised to Simcere and represents the Company's best estimate of the period of the obligation. The performance obligation related to certain rademikibart development services was completed in 2024.

*Milestone Payments* 

The Licensor is entitled to development milestones under the License Agreement and certain regulatory milestone payments which are paid upon receipt of regulatory approvals within the Territory.

At the end of each reporting period, the Company will re-evaluate the probability of achievement of each milestone and any related constraint, and if necessary, adjust its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative catch-up basis, which would affect the reported amount of license and collaboration revenues in the period of adjustment.

*Royalties*

As the license is deemed to be the predominant item to which sales-based royalties relate, the Company will recognize revenue when the related sales occur.

*Contract Assets and Liabilities*

As of March 31, 2026, the Company had no contract assets or liabilities related to the License Agreement. As of December 31, 2025, the Company had no contract assets and $0.2 million in contract liabilities related to the upfront fee received under the License Agreement. During the three months ended March 31, 2026, the remaining $0.2 million of the contract liability was recognized as revenue, which was included in the contract liability balance at the beginning of the year.

**7. Commitments and Contingencies**

***Legal Proceedings***

From time to time, the Company may be a party to litigation or subject to claims in the ordinary course of business. Regardless of the outcome, litigation can have an adverse impact on the Company because of defense and settlement costs, diversion of management resources and other factors. The Company was not a party to any material litigation and did not have contingency reserves established for any liabilities as of March 31, 2026 or December 31, 2025.

**8. Leases**

We have an operating lease for 6,942 square feet of office space for our corporate headquarters in San Diego, California, with a lease term that expires on January 31, 2028. In the first quarter of 2025, we recognized an initial right-of-use ("ROU") lease asset of $0.9 million and a lease liability of $0.9 million related to this space in San Diego, California.

We also have an operating lease for 25,476 square feet of laboratory and office space in Taicang, China. In March 2026, we amended the lease to extend the term for one year until April 30, 2027. In the first quarter of 2026, we recognized an ROU lease asset of $0.1 million and a lease liability of $0.1 million related to the lease amendment.

As of March 31, 2026 and December 31, 2025, the weighted average remaining lease term was 1.7 years and 2.0 years, respectively, and the weighted average discount rate used to determine the operating lease liability was 7.7% and 8.1%, respectively.

During the three months ended March 31, 2026 and 2025, we recognized $106,000 and $125,000, respectively, of operating lease expense and we paid $109,000 and $76,000, respectively, for our operating leases.

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Annual future minimum lease payments as of March 31, 2026 are as follows (in thousands):

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| | |
|:---|:---|
| 2026 (remainder of year) | $331 |
| 2027 | 379 |
| 2028 | 30 |
| Thereafter |  |
| Total future minimum lease payments | 740 |
| Less: amount representing interest | (47) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total lease liabilities | $693 |

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**9. Shareholders' Equity**

***Private Placement***

In March 2026, the Company entered into a securities purchase agreement with a select group of institutional accredited investors to sell 6,130,000 shares of its ordinary shares in a private placement at a price of $3.25 per share with respect to any purchaser that is not owned or controlled by an individual who is an officer, director, employee or consultant of the Company ("Private Placement"). The estimated net proceeds from the Private Placement were $18.6 million (gross proceeds of $20.2 million, net of $1.6 million in estimated placement agent fees and other offering expenses). The Private Placement closed on March 31, 2026.

The Private Placement was led by the Company's largest current investor, Panacea Venture, which purchased ordinary shares in the Private Placement totaling $4.0 million. James Huang, a member of our Board, is the sole owner of Panacea Innovation Limited, which is the sole owner of Panacea Venture.

***Statutory Reserves***

In accordance with the People's Republic of China ("PRC") regulations and the articles of association of the companies registered in the PRC, companies are required to set aside 10% of their net profit for the year, offsetting any prior year losses, to the statutory surplus reserve fund as determined under the relevant PRC accounting standards. When the balance of such reserve reaches 50% of the entity's registered capital, any further appropriation is optional. As of March 31, 2026, we have not made any profit appropriations to the reserve fund, as all of our subsidiaries in the PRC were in an accumulated loss position.

Under PRC laws and regulations, there are restrictions on the Company's PRC subsidiaries with respect to transferring certain of their net assets to the Company either in the form of dividends, loans, or advances. As of March 31, 2026 and December 31, 2025, restricted net assets including paid-in capital and statutory reserve funds of the Company's PRC subsidiaries was $14.9 million and $15.7 million, respectively.

**10. Equity Incentive Plans**

***Equity Compensation Plan Activity***

The following table summarizes all stock option plan activity for the three months ended March 31, 2026:

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| | | |
|:---|:---|:---|
| | **Outstanding Options** | **Outstanding Options** |
| | **Number of Options** | **Weighted-Average <br>Exercise Price** |
| Outstanding at December 31, 2025 | 15190575 | $2.14 |
| &nbsp;&nbsp;&nbsp;&nbsp;Granted | 263800 | $2.50 |
| &nbsp;&nbsp;&nbsp;&nbsp;Exercised | (131505) | $1.04 |
| &nbsp;&nbsp;&nbsp;&nbsp;Cancelled | (155233) | $8.73 |
| Outstanding at March 31, 2026 | 15167637 | $2.08 |

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In accordance with our Non-Employee Director Compensation Program, certain non-employee directors elected to receive fully vested shares in lieu of all or a portion of their 2026 annual cash board retainers. Accordingly, fully vested ordinary shares were granted to these directors for their service as a director during the first quarter of 2026. The number of shares received in lieu of cash was calculated by dividing the applicable value of the equity by the average closing price of our ordinary shares over the 30 consecutive days immediately preceding March 31, 2026, rounded down to the nearest whole share. On March 31, 2026, we granted certain non-employee directors 7,877 fully vested ordinary shares. The weighted-average grant date fair value of these shares was $2.62.

***Share-based Compensation***

The following table summarizes share-based compensation expense related to share-based payment awards granted pursuant to all of our equity compensation arrangements (in thousands):

---

| | | |
|:---|:---|:---|
| | **Three Months Ended March 31,** | **Three Months Ended March 31,** |
| | **2026** | **2025** |
| Research and development | $277 | $331 |
| General and administrative | 922 | 611 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total share-based compensation expense | $1199 | $942 |

---

As of March 31, 2026, there was $12.6 million of total unrecognized compensation cost related to non-vested, share-based payment awards granted under all of our equity compensation plans. Total unrecognized compensation cost will be adjusted for forfeitures. We expect to recognize this compensation cost over a weighted-average period of 2.8 years.

The following are the weighted-average assumptions for stock options:

---

| | | |
|:---|:---|:---|
| | **Three Months Ended March 31,** | **Three Months Ended March 31,** |
| | **2026** | **2025** |
| Risk-free interest rate | 3.6% | 4.4% |
| Dividend yield | 0.0% | 0.0% |
| Volatility | 107.0% | 109.6% |
| Expected life (years) | 5.6 | 6.1 |

---

The weighted-average fair value of options granted was $2.03 and $0.81 for the three months ended March 31, 2026 and 2025, respectively.

**11. Income Taxes**

For the three months ended March 31, 2026 and 2025, we recorded income tax expense of $48,000 and $54,000, respectively. Our effective tax rate for the three months ended March 31, 2026 and 2025 was (0.2)% and (0.5)%, respectively. The effective tax rate in both periods was primarily driven by the full valuation allowance maintained against the Company's deferred tax assets.

For the three months ended March 31, 2026, the Company's provision for income taxes was based on its worldwide estimated annualized effective tax rate, except for (1) jurisdictions for which a loss is expected for the year and no benefit can be realized for those losses, (2) jurisdictions for which forecasted pre-tax income or loss cannot be estimated, and (3) the tax effect of discrete items occurring during the period. The tax for jurisdictions for which a forecast cannot be estimated is based on actual taxes and tax reserves for the quarter.

Under the provisions of ASC 740, *Income Taxes*, the determination of the Company's ability to recognize its deferred tax assets requires an assessment of both negative and positive evidence. The evidence evaluated by the Company included operating results during the most recent three-year period and future projections, with more weight given to historical results than expectations of future profitability, which are inherently uncertain. Certain entities' net losses in recent periods represented sufficient negative evidence to require a valuation allowance against its net deferred tax assets. Due to the uncertainties surrounding our ability to generate future taxable income and consequently realize such deferred tax assets, a full valuation allowance has been established. This valuation allowance will be evaluated periodically and could be reversed partially or totally if business results sufficiently improve to support realization of deferred tax assets.

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As of March 31, 2026, unrecognized tax benefits were $1.3 million, of which none would affect the effective tax rate, if recognized. It is the Company's policy to classify accrued interest and penalties to unrecognized tax benefits in the provision for income taxes. There were no accrued interest or penalties as of March 31, 2026 or December 31, 2025. During the three months ended March 31, 2026, there were no material changes to the disclosures regarding uncertain tax positions included in our 2025 Annual Report.

**12. Segment Reporting**

The Company operates in one operating segment: treatment of respiratory diseases. Operating segments are identified as components of an enterprise about which separate discrete financial information is available for evaluation by the Chief Operating Decision-Maker (the "CODM"), our Chief Executive Officer, in making decisions regarding resource allocation and assessing performance. The CODM utilizes the Company's consolidated financial forecast, which includes product development roadmaps, as a key input to resource allocation. The CODM makes decisions on resource allocation, assesses performance of the business, and monitors budget versus actual results using our operating expenses, cash burn and cash runway.

The following table provides significant segment expenses, other segment items, reported segment net loss and a reconciliation of segment net loss to the Company's total consolidated net loss for the three months ended March 31, 2026 and 2025 (in thousands):

---

| | | |
|:---|:---|:---|
| | **Three Months Ended March 31,** | **Three Months Ended March 31,** |
| | **2026** | **2025** |
| &nbsp;&nbsp;&nbsp;&nbsp;License and collaboration revenues | $169 | $— |
| &nbsp;&nbsp;&nbsp;&nbsp;Research and development expense | (15030) | (6633) |
| &nbsp;&nbsp;&nbsp;&nbsp;General and administrative expense | (4746) | (4814) |
| &nbsp;&nbsp;&nbsp;&nbsp;Other income, net | 257 | 1229 |
| &nbsp;&nbsp;&nbsp;&nbsp;Income tax expense | (48) | (54) |
| Segment net loss | (19398) | (10272) |
| Reconciliation of loss: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Adjustments and reconciling items |  |  |
| Consolidated net loss | $(19398) | $(10272) |

---

The Company's long-lived tangible assets, as well as the Company's ROU lease assets recognized on the condensed consolidated balance sheets as of March 31, 2026 and December 31, 2025 were located as follows: $0.6 million and $0.7 million, respectively, in the U.S. and $3.7 million and $3.8 million, respectively, in the PRC.

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**Item 2. Management's Discussion and Analysis of Financial Condition and Results of Operations.**

The following discussion and analysis of our financial condition and results of operations should be read together with our condensed consolidated financial statements and related notes included in this Quarterly Report on Form 10-Q and the audited financial statements and related notes included in our 2025 Annual Report.

**Forward-Looking Statements**

This Quarterly Report on Form 10-Q, including the sections entitled "Risk Factors" and "Management's Discussion and Analysis of Financial Condition and Results of Operations," contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended (the "Securities Act"), and Section 21E of the Exchange Act. All statements other than statements of historical facts contained in this Quarterly Report on Form 10-Q, including statements regarding our strategy, future events, future financial condition, revenues or performance, future operations, financing needs, business trends, research and development, potential of, and expectations for, our pipeline and technology platforms, the timing, potential of and expectations for planned clinical trials and preclinical studies, the timing and likelihood of regulatory filings and approvals for our product candidates, our ability to commercialize our product candidates, the potential benefits of collaborations, projected costs, prospects, plans, goals, objectives of management, expected market size and growth for our potential products, the timing of availability of clinical data, program updates and data disclosures, and our plans for rademikibart, are forward-looking statements. These statements may be identified by the use of words such as "aim," "anticipate," "assume," "believe," "commitments," "contemplate," "continue," "could," "design," "due," "estimate," "expect," "goal," "intend," "may," "might", "objective," "plan," "positioned," "potential," "predict," "seek," "should," "target," "will," "would" and other similar expressions that are predictions of or indicate future events and future trends, or the negative of these terms or other comparable terminology. The forward-looking statements in this Quarterly Report are only predictions. We have based these forward-looking statements largely on our current assumptions, expectations and projections about future events and financial trends that we believe may affect our financial condition, operating results, business strategy, short-term and long-term business operations and objectives. These forward-looking statements speak only as of the date of this Quarterly Report on Form 10-Q and are subject to a number of substantial known and unknown risks, uncertainties and assumptions, including those described in Part I, "Item 1A. Risk Factors" of our 2025 Annual Report, Part II, "Item 1A, "Risk Factors" of this Quarterly Report on Form 10-Q and our other filings with the SEC. The events and circumstances reflected in our forward-looking statements may not be achieved or occur and actual results or outcomes, or the timing of such results or outcomes, could differ materially from those expressed or implied in the forward-looking statements. Given these risks, uncertainties and other important factors, you should not place undue reliance on these forward-looking statements. Except as required by applicable law, we do not plan to publicly update or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise.

**Overview**

Connect Biopharma, headquartered in San Diego, California, is a clinical-stage biopharmaceutical company dedicated to transforming care for asthma and COPD. The Company is advancing rademikibart, a next-generation, potentially best-in-class antibody designed to target IL-4Rα.

***Significant Developments***

The following is a summary of significant developments affecting our business that have occurred since the filing of our 2025 Annual Report. For a more comprehensive discussion of our product candidate, rademikibart, see our 2025 Annual Report.

On March 31, 2026, the Company completed its previously announced private placement with gross proceeds of $20.2 million and estimated net proceeds of $18.6 million.

In April 2026, the Company announced that the independent data monitoring committee overseeing its Phase 2 Seabreeze STAT asthma and COPD studies reviewed the pre-specified interim analysis of efficacy data with no recommendation for change in the sample size and confirmed that is has no safety concerns based on a regular review of safety data.

**Critical Accounting Estimates**

Our discussion and analysis of our financial condition and results of operations is based on our unaudited condensed consolidated financial statements, which have been prepared in accordance with U.S. GAAP. The preparation of these financial statements requires us to make estimates and judgments that affect the reported amounts of assets, liabilities,

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revenues and expenses, and related disclosures. We evaluate our estimates on an ongoing basis, including those related to revenue recognition and accrued research and development expenses. We base our estimates on historical experience and on assumptions that we believe to be reasonable under the circumstances, the results of which form the basis of making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. Actual results may differ materially from these estimates under different assumptions or conditions.

During the three months ended March 31, 2026, there have been no material changes to our critical accounting estimates and judgments, as described within Item 7 of our 2025 Annual Report.

**Recent Accounting Pronouncements**

See Note 3 to the condensed consolidated financial statements included in Item 1 of this Quarterly Report on Form 10-Q.

**Results of Operations**

***Comparison of the Three Months Ended March 31, 2026 and 2025***

*License and Collaboration Revenues*

License and collaboration revenues relate to the Simcere License Agreement under which Simcere has been granted exclusive rights to develop, manufacture, and commercialize rademikibart for all indications in Greater China, including mainland China, Hong Kong, Macau, and Taiwan.

License and collaboration revenues for the three months ended March 31, 2026 were $0.2 million, and were related to the upfront license fee under the Simcere License Agreement. There were no license and collaboration revenues for the three months ended March 31, 2025.

*Research and Development Expense*

Research and development expense consisted of the following (in thousands):

---

| | | |
|:---|:---|:---|
| | **Three Months Ended March 31,** | **Three Months Ended March 31,** |
| | **2026** | **2025** |
| Rademikibart-related costs | $11560 | $3656 |
| Other development related costs |  | 73 |
| Personnel costs and other expenses | 3193 | 2573 |
| Share-based compensation expense | 277 | 331 |
| Total research and development expense | $15030 | $6633 |

---

For the three months ended March 31, 2026, research and development expense was $15.0 million, compared to $6.6 million for the same period in 2025. The increase in research and development expense was primarily due to an increase in costs related to the development of rademikibart. During the second quarter of 2025, we initiated two rademikibart Phase 2 clinical trials in patients experiencing an acute exacerbation of asthma or COPD.

*General and Administrative Expense*

For the three months ended March 31, 2026 and 2025, general and administrative expense was comparable at $4.7 million and $4.8 million, respectively.

*Other Income, Net*

For the three months ended March 31, 2026, other income, net was $0.3 million, compared to $1.2 million for the same period in 2025. The decrease in other income, net was primarily due to a decrease in government subsidies and interest income earned on our invested cash balances.

**Liquidity and Capital Resources**

Our net cash used in operating activities for the three months ended March 31, 2026 was $16.0 million, compared to $10.0 million for the same period in 2025. The increase in net cash used in operating activities was primarily due to an increase in net loss of $9.1 million, partially offset by net changes in our operating assets and liabilities of $2.6 million.

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Our net cash provided by investing activities for the three months ended March 31, 2026 was $6.0 million, compared to net cash used in investing activities of $20.6 million for the same period in 2025. The increase in cash provided by investing activities was primarily due to net maturities of short-term investments of $6.0 million for the three months ended March 31, 2026, compared to net purchases of short-term investments of $20.6 million for the three months ended March 31, 2025.

Our net cash provided by financing activities for the three months ended March 31, 2026 was $17.6 million, compared to $2,000 for the same period in 2025. The increase in net cash provided by financing activities was primarily due to the Private Placement which closed in March 2026.

***Liquidity and Material Cash Requirements***

As of March 31, 2026, we had cash and cash equivalents of $46.0 million. Based on our current operating plan and projections, management believes that our existing cash and cash equivalents will be sufficient to meet our anticipated cash requirements for a period of at least one year from the date this Quarterly Report on Form 10-Q is filed with the SEC.

Historically, we have financed our operations, including technology and product research and development, primarily through sales of our securities, including our IPO that we completed in March 2021 for total cash consideration of $219.9 million before underwriting discounts and commissions, and the Private Placement (as discussed below), and through up-front payments, research funding and milestone payments under collaborative arrangements.

In March 2026, we entered into a securities purchase agreement with a select group of accredited investors to sell 6,130,000 shares of our ordinary shares in a private placement ("Private Placement"). The estimated net proceeds from the Private Placement were $18.6 million (gross proceeds of $20.2 million, net of $1.6 million in estimated placement agent fees and other offering expenses). The Private Placement closed on March 31, 2026.

We have an operating lease for our corporate headquarters in San Diego, California for 6,942 square feet of office space, which expires on January 31, 2028. We have agreed to pay a basic annual rent for the additional office space that increases incrementally over the term of the lease from $0.3 million for the first 12 months of the lease (inclusive of certain rent abatements) to $0.4 million for the last 12 months of the lease, and such other amounts as set forth in the lease.

In addition, we have a lease for 25,476 square feet of laboratory and office space in Taicang, China, with a lease term that expires on April 30, 2027. As of March 31, 2026, we had total operating lease obligations of $0.7 million, with $0.3 million due during the remainder of fiscal year 2026 and $0.4 million due within the following two to three years.

We enter into agreements with clinical sites and clinical research organizations for the conduct of our clinical trials and contract manufacturing organizations for the manufacture and supply of preclinical, clinical and, potential future, commercial materials and drug product. We make payments to these clinical sites and clinical research organizations based in part on the number of eligible patients enrolled and the length of their participation in the clinical trials. Under certain of these agreements, we may be subject to penalties in the event that we prematurely terminate these agreements. At this time, due to the variability associated with clinical site agreements, contract research organization agreements and contract manufacturing agreements, we are unable to estimate with certainty the future costs we will incur. We intend to use our current financial resources to fund our obligations under these commitments.

We have based our estimates on assumptions that may prove to be wrong, and we may use our available capital resources sooner than we currently expect. Because of the numerous risks and uncertainties associated with the development of product candidates and programs, and because the extent to which we may enter into collaborations with third parties for development of our product candidates is unknown, we are unable to estimate the timing and amounts of increased capital outlays and operating expenses associated with completing the research and development of our product candidates. Our future capital requirements will depend on many factors, including:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• our ability to raise capital and the impact on our business of adverse global macroeconomic and geopolitical conditions, including high interest rates, the inflationary environment, recessionary fears, foreign exchange rate volatility, instability in financial institutions, government shutdowns, changes in monetary policy, changes in trade policies, including tariffs and other trade restrictions or the threat of such actions, and rising geopolitical instability, including the conflicts in the Middle East and the related volatility in the price of oil and other commodity prices;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• the scope, progress, results, and costs of drug discovery, preclinical development, laboratory testing, and clinical trials for the product candidates we may develop;

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• the costs associated with our manufacturing process development and evaluation of third-party manufacturers and suppliers;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• the costs, timing and outcome of regulatory review of our product candidates;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• the costs of preparing and submitting marketing approvals for any of our product candidates that successfully complete clinical trials, and the costs of maintaining marketing authorization and related regulatory compliance for any products for which we obtain marketing approval;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• the costs of preparing, filing, and prosecuting patent applications, maintaining and enforcing our intellectual property and proprietary rights, and defending intellectual property-related claims;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• the costs of future activities, including product sales, medical affairs, marketing, manufacturing, and distribution, for any product candidates for which we receive marketing approval;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• the terms of our current and any future license agreements and collaborations;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• the extent to which we acquire or in-license other product candidates, technologies and intellectual property;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• the success of our ongoing or future collaborations;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• our ability to establish and maintain additional collaborations on favorable terms, if at all; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• the costs of operating as a public company.

Until such time, if ever, that we can generate product revenue sufficient to achieve profitability, we expect to finance our cash needs through a combination of equity offerings, debt financings, collaborations, monetization transactions, government contracts or other strategic transactions. To the extent that we raise additional capital through the sale of equity, ownership interests of existing holders of our ordinary shares will be diluted, and the terms of these securities may include liquidation or other preferences that adversely affect the rights of holders of our ordinary shares. If we raise additional funds through collaboration agreements, strategic alliances, licensing arrangements, monetization transactions, or marketing and distribution arrangements, we may have to relinquish valuable rights to our technologies, future revenue streams, research programs or product candidates or grant licenses on terms that may not be favorable to us or grant rights to develop and market products or product candidates that we would otherwise prefer to develop and market ourselves. Future debt financing, if available, may involve covenants restricting our operations or our ability to incur additional debt. Any debt or equity financing that we raise may contain terms that are not favorable to us or our shareholders.

There have been significant disruptions to global financial markets and a general adverse global macroeconomic environment. Unstable market and macroeconomic conditions may have serious adverse consequences on our business, financial condition and stock price. Any increase in inflation rates may materially affect our business and corresponding financial position and cash flows. Inflationary factors, such as increases in the cost of our clinical trial materials and supplies, interest rates and overhead costs may adversely affect our operating results. High interest rates also present a challenge impacting the U.S. economy and could make it more difficult for us to obtain traditional financing on acceptable terms, if at all, in the future. Additionally, the general consensus among economists suggests that we should expect a higher recession risk to continue, which, together with the foregoing, could result in further macroeconomic uncertainty and volatility in the capital markets in the near term, and could negatively affect our operations. Furthermore, such macroeconomic conditions have produced downward pressure on share prices. Although we do not believe that inflation has had a material impact on our financial position or results of operations to date, we may experience impacts in the near future (especially if inflation rates remain high or begin to rise again) on our operating costs, including our labor costs and research and development costs. Our costs, business, financial position and cash flows could also be impacted by other macroeconomic factors, including supply chain constraints, consequences associated with geopolitical conflicts such as the ongoing conflicts in Ukraine and in the Middle East, including the related volatility in the price of oil and other commodity prices, the impact of tariffs imposed by or on the U.S., as well as other tariff-related developments and other matters impacting global trade, shifting priorities and policies within the U.S. federal government and government agencies, government shutdowns, and employee availability and wage increases, which may result in additional stress on our working capital resources. If we are unable to raise capital when needed or on attractive terms, we would be forced to delay, reduce, or eliminate our research and development programs or potential future commercialization efforts.

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**Item 3. Quantitative and Qualitative Disclosures About Market Risk.**

We are a smaller reporting company, as defined by Rule 12b-2 under the Exchange Act and in Item 10(f)(1) of Regulation S-K, and are not required to provide the information under this item.

**Item 4. Controls and Procedures.**

We maintain disclosure controls and procedures that are designed to ensure that information required to be disclosed in the reports that we file with the SEC is recorded, processed, summarized, and reported within the time periods specified in the SEC's rules and forms, and that such information is accumulated and communicated to our management, including our principal executive officer and principal financial officer, as appropriate, to allow timely decisions regarding required disclosure. In designing and evaluating the disclosure controls and procedures, management recognized that any controls and procedures, no matter how well designed and operated, can provide only reasonable and not absolute assurance of achieving the desired control objectives. In reaching a reasonable level of assurance, management necessarily was required to apply its judgment in evaluating the cost-benefit relationship of possible controls and procedures. In addition, the design of any system of controls is based in part upon certain assumptions about the likelihood of future events, and there can be no assurance that any design will succeed in achieving its stated goals under all potential future conditions; over time, controls may become inadequate because of changes in conditions, or the degree of compliance with policies or procedures may deteriorate. Because of the inherent limitations in a cost-effective control system, misstatements due to error or fraud may occur and not be detected.

As of March 31, 2026, we carried out an evaluation, under the supervision and with the participation of our management, including our principal executive officer and principal financial officer, of the effectiveness of the design and operation of our disclosure controls and procedures, as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended. Based on this evaluation, our principal executive and financial officers concluded that our disclosure controls and procedures were effective at the reasonable assurance level as of March 31, 2026.

An evaluation was also performed under the supervision and with the participation of our management, including our principal executive officer and principal financial officer, of any change in our internal control over financial reporting that occurred during our last fiscal quarter and that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting. That evaluation did not identify any changes in our internal control over financial reporting that occurred during our latest fiscal quarter that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.

**PART II—OTHER INFORMATION**

**Item 1. Legal Proceedings.**

From time to time, we may become involved in legal proceedings arising in the ordinary course of our business. We are not currently party to any material legal proceedings, and we are not aware of any pending or threatened legal proceeding against us that we believe could have a material adverse effect on our business, operating results or financial condition.

**Item 1A. Risk Factors.**

We operate in a rapidly changing environment that involves a number of risks that could materially affect our business, financial condition or future results, some of which are beyond our control. In addition to the other information set forth in this report, the risks and uncertainties that we believe are most important for you to consider are discussed in Part I, "Item 1A. Risk Factors" in our 2025 Annual Report. We are not aware of any material changes to the risk factors described in our 2025 Annual Report.

**Item 2. Unregistered Sales of Equity Securities and Use of Proceeds.**

*<u>Unregistered Sales of Equity Securities</u>*

Except as disclosed in a Current Report on Form 8-K filed with the SEC on March 30, 2026, there were no other sales of unregistered equity securities during the quarter ended March 31, 2026.

*<u>Issuer Purchases of Equity Securities</u>*

None.

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**Item 3. Defaults Upon Senior Securities.**

None.

**Item 4. Mine Safety Disclosures.**

Not applicable.

**Item 5. Other Information.**

*<u>(c) Trading Plans</u>*

During the quarter ended March 31, 2026, none of our directors or Section 16 officers adopted or terminated a (i) Rule 10b5-1 trading arrangement (as defined in Item 408(a) of Regulation S-K) or (ii) non-Rule 10b5-1 trading arrangement (as defined in Item 408(c) of Regulation S-K).

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**Item 6. Exhibits.**

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| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| | | **Incorporation by Reference** | **Incorporation by Reference** | **Incorporation by Reference** | **Incorporation by Reference** | |
|<br>**Exhibit No.** |<br>**Description** | **Form** | **File No.** | **Exhibit Reference** | **Filing Date** |<br>**Filed or Furnished Herewith** |
| 10.1 | <u>[Securities Purchase Agreement, dated March 29, 2026, by and between Connect Biopharma Holdings Limited and each of the purchasers party thereto](https://www.sec.gov/Archives/edgar/data/1835268/000183526826000006/exhibit101-securitiespurch.htm)</u> | 8-K | 001-40212 | 10.1 | 3/30/2026 |  |
| 31.1 | <u>[Certification of Principal Executive Officer pursuant to Rules 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002](cntb-20260331ex311.htm)</u> |  |  |  |  | Filed |
| 31.2 | <u>[Certification of Principal Financial Officer Pursuant to Rules 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002](cntb-20260331ex312.htm)</u> |  |  |  |  | Filed |
| 32.1# | <u>[Certifications of Principal Executive Officer and Principal Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002](cntb-20260331ex321.htm)</u> |  |  |  |  | Furnished |
| 101.INS | Inline XBRL Instance Document – the instance document does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline XBRL document |  |  |  |  | Filed |
| 101.SCH | Inline XBRL Taxonomy Extension Schema Document |  |  |  |  | Filed |
| 101.CAL | Inline XBRL Taxonomy Extension Calculation Linkbase Document |  |  |  |  | Filed |
| 101.DEF | Inline XBRL Taxonomy Definition Linkbase Document |  |  |  |  | Filed |
| 101.LAB | Inline XBRL Taxonomy Extension Label Linkbase Document |  |  |  |  | Filed |
| 101.PRE | Inline XBRL Taxonomy Extension Presentation Linkbase Document |  |  |  |  | Filed |
| 104 | Cover Page Interactive Data File (embedded within the Inline XBRL document and contained in Exhibit 101) |  |  |  |  | Filed |

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# The certifications attached as Exhibit 32.1 that accompany this Quarterly Report on Form 10-Q are not deemed filed with the Securities and Exchange Commission and are not to be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, whether made before or after the date of this Quarterly Report on Form 10-Q, irrespective of any general incorporation language contained in such filing.

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**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

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| | |
|:---|:---|
| | **Connect Biopharma Holdings Limited** |
| Date: May 12, 2026 | /s/ Barry D. Quart |
|  | Barry D. Quart, Pharm.D. |
|  | Chief Executive Officer |
|  | (Registrant's Principal Executive Officer) |
| Date: May 12, 2026 | /s/ Lisa Peraza |
|  | Lisa Peraza |
|  | Senior Vice President of Finance |
|  | (Registrant's Principal Financial and Accounting Officer) |

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## Exhibit 31.1

**Exhibit 31.1**

**CERTIFICATION**

**Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002**

I, Barry D. Quart, certify that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.I have reviewed this quarterly report on Form 10-Q of Connect Biopharma Holdings Limited;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.The registrant's other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a)designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b)designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;c)evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;d)disclosed in this report any change in the registrant's internal control over financial reporting that occurred during the registrant's most recent fiscal quarter that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.The registrant's other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a)all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b)any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.

---

| | |
|:---|:---|
| Date: May 12, 2026 | /s/ Barry D. Quart |
| | Barry D. Quart, Pharm.D. |
| | Chief Executive Officer |
| | (Registrant's Principal Executive Officer) |

---

## Exhibit 31.2

**Exhibit 31.2**

**CERTIFICATION**

**Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002**

I, Lisa Peraza, certify that:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.I have reviewed this quarterly report on Form 10-Q of Connect Biopharma Holdings Limited;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.The registrant's other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a)designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b)designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;c)evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;d)disclosed in this report any change in the registrant's internal control over financial reporting that occurred during the registrant's most recent fiscal quarter that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.The registrant's other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;a)all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;b)any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.

---

| | |
|:---|:---|
| Date: May 12, 2026 | /s/ Lisa Peraza |
| | Lisa Peraza |
| | Senior Vice President of Finance |
| | (Registrant's Principal Financial and Accounting<br>Officer) |

---

## Exhibit 32.1

**Exhibit 32.1**

**CERTIFICATION PURSUANT TO**

**18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO**

**SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002**

In connection with the quarterly report of Connect Biopharma Holdings Limited (the "Company") on Form 10-Q for the quarterly period ended March 31, 2026, as filed with the Securities and Exchange Commission on or about the date hereof (the "Report"), the undersigned, Barry D. Quart, Pharm.D., Chief Executive Officer of the Company, and Lisa Peraza, Senior Vice President of Finance of the Company, each certify, pursuant to 18 U.S.C. §1350, as adopted pursuant to §906 of the Sarbanes-Oxley Act of 2002, that, to the best of their knowledge:

(1)the Report fully complies with the requirements of Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"); and

(2)the information contained in the Report fairly presents, in all material respects, the financial condition of the Company at the end of the period covered by the Report and results of operations of the Company for the period covered by the Report.

---

| | |
|:---|:---|
| Date: May 12, 2026 | /s/ Barry D. Quart |
|  | Barry D. Quart, Pharm.D. |
|  | Chief Executive Officer |
|  | (Registrant's Principal Executive Officer) |
| Date: May 12, 2026 | /s/ Lisa Peraza |
|  | Lisa Peraza |
|  | Senior Vice President of Finance |
|  | (Registrant's Principal Financial and Accounting <br>Officer) |

---

This certification shall not be deemed "filed" for purposes of Section 18 of the Exchange Act or otherwise subject to the liability of Section 18 of the Exchange Act. Such certification shall not be deemed to be incorporated by reference into any filing under the Securities Act of 1933, as amended, or the Exchange Act, except to the extent that the Company specifically incorporates it by reference.

<br>