# EDGAR Filing Document

**Accession Number:** 0001002624
**File Stem:** 0001002624-23-000010
**Filing Date:** 2023-2
**Character Count:** 90820
**Document Hash:** 019a3b36299cd20ddcebd12daca4a53e
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001002624-23-000010.hdr.sgml**: 20230224

**ACCESSION NUMBER**: 0001002624-23-000010

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230224

**DATE AS OF CHANGE**: 20230224

**PERIOD START**: 20221231

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** T. Rowe Price Health Sciences Fund, Inc.
- **CENTRAL INDEX KEY:** 0001002624
- **IRS NUMBER:** 521952906
- **STATE OF INCORPORATION:** MD
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-07381
- **FILM NUMBER:** 23667615

**BUSINESS ADDRESS:**
- **STREET 1:** 100 EAST PRATT STREET
- **CITY:** BALTIMORE
- **STATE:** MD
- **ZIP:** 21202
- **BUSINESS PHONE:** 410-345-2000

**MAIL ADDRESS:**
- **STREET 1:** 100 EAST PRATT STREET
- **CITY:** BALTIMORE
- **STATE:** MD
- **ZIP:** 21202

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** PRICE T ROWE HEALTH SCIENCES FUND INC
- **DATE OF NAME CHANGE:** 19980513

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** PRICE T ROWE HEALTH & LIFE SCIENCES FUND INC
- **DATE OF NAME CHANGE:** 19951023

## Series and Classes Contracts Data

### T. Rowe Price Health Sciences Fund, Inc. (Series ID: S000002088)

| Class ID   | Class Name                                 | Ticker Symbol   |
|:---|:---|:---|
| C000005456 | T. Rowe Price Health Sciences Fund, Inc.   | PRHSX           |
| C000169937 | T. Rowe Price Health Sciences Fund-I Class | THISX           |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** T. ROWE PRICE HEALTH SCIENCES FUND, INC.

- **b. Investment Company Act file number:** 811-07381

- **c. CIK number of Registrant:** 0001002624

- **d. LEI of Registrant:** 549300ELV6FPY6UQBJ78

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 100 East Pratt Street

  - **City:** Baltimore

  - **State:** MD

  - **Foreign country:** US

  - **Zip / Postal Code:** 21202

  - **Telephone number:** 410-345-2000

**Item A.2. Information about the Series.**

- **a. Name of Series:** T. Rowe Price Health Sciences Fund, Inc.

- **b. EDGAR series identifier (if any):** S000002088

- **c. LEI of Series:** 66LP7EMLZS5S33LWIH41

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2022-12-31

- **b. Date as of which information is reported:** 2022-12-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $16232002221.14

**Total Liabilities:** $28343431.07

**Net Assets:** $16203658790.07

**Assets Attributable to Miscellaneous Securities:** $674954681.44

**Delayed Delivery Securities:** $10177345.44

**Cash Not Reported:** $590146.67

**Currency Risk Metrics (dv01):**

- 

**Credit Spread Risk - Investment Grade (dv01):**

- **3-Month:** 0.000000 | **1-Year:** 0.000000 | **5-Year:** 0.000000 | **10-Year:** 0.000000 | **30-Year:** 0.000000

**Credit Spread Risk - Non-Investment Grade (dv01):**

- **3-Month:** 0.000000 | **1-Year:** 0.000000 | **5-Year:** 0.000000 | **10-Year:** 0.000000 | **30-Year:** 0.000000

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000169937 | 7.70%                | 4.18%                | -2.97%               |
| Class ID C000005456 | 7.68%                | 4.16%                | -2.97%               |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $-29075317.28            | $1198740656.30                             |
| Month 2  | $52690485.93             | $622546164.75                              |
| Month 3  | $30267607.29             | $-534068122.45                             |

### Schedule of Portfolio Investments

| Name                                            | Title                                              | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)    | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| N/A                                             | ELEMENT BIOSCIENCES SER C CVT PFD STOCK            | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    861217 | NS      | $17703779.50   | 0.11%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | EIKON THERA SERIES B CVT PFD STOCK PP              | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1018820 | NS      | $18021473.17   | 0.11%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | FLAME BIOSCIENCES INC PP                           | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    839721 | NS      | $3854319.39    | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | HONOR TECHNOLOGY SER D CVT PFD PP                  | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   3130941 | NS      | $7201164.30    | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | REFLEXION MEDICAL INC SR E CVT PFD PP              | CUSIP: TC9L8ZXJ6<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1857286 | NS      | $4402780.04    | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | SIONNA THERAPEUTICS SR B CVT PFD STK PP            | CUSIP: TC9JBHH97<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    541277 | NS      | $5283946.07    | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | TEMPUS LAB SERIES E CVT PFD STOCK PP               | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    633505 | NS      | $38289042.20   | 0.24%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | AFFINIVAX EXPENSE FUND PP                          | CUSIP: TC929D1E2<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     12445 | NS      | $11823.17      | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | ARBOR BIO SERIES B CVT PFD STOCK PP                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    532759 | NS      | $8827816.63    | 0.05%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Freenome Inc                                    | FREENOME HOLDINGS SER C CVT PFD PP                 | CUSIP: TC87S2BF1<br>LEI: 254900QDTSQ6S0QOCS43 | Long             | EP               | CORP              | US        |    928231 | NS      | $10832455.77   | 0.07%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | TESSERA THERAPEUTICS SR C CVT PFD STK PP           | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    387032 | NS      | $7914804.40    | 0.05%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Exact Sciences Corp                             | EXACT SCIENCES FDA MILESTONE PP                    | CUSIP: 000000000<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |   1863136 | NS      | $987462.00     | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | DELFI DIAGNOSTICS SR B CVT PFD STOCK PP            | CUSIP: TC7ZV25B2<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1853138 | NS      | $8979491.37    | 0.06%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Gyroscope Therapeutics Ltd                      | GYROSCOPE THERAPEUTICS MILESTONE PAYMENT 1 PP      | CUSIP: 000000000<br>LEI: 21380066POJ2YSHZAD73 | Long             | EC               | CORP              | US        |   5683928 | NS      | $2785124.72    | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | INSCRIPTA SERIES E CVT PFD STOCK PP                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1452941 | NS      | $8107410.78    | 0.05%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | TEMPUS LABS SERIES F CVT PFD STOCK PP              | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    172826 | NS      | $10583864.24   | 0.07%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | RING THERA SER B CVT PFD STOCK PP                  | CUSIP: TC7JBYSO7<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    978705 | NS      | $9004086.00    | 0.06%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | TEMPUS LAB SERIES G CVT PFD                        | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    111715 | NS      | $6924095.70    | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | PrognomIQ Series A-4 Pfd                           | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    593540 | NS      | $1816232.40    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | AFFINIVAX NEXT GEN PROD MILESTON EVNT PP           | CUSIP: TC7BEY6E7<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   7349672 | NS      | $1616927.84    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | REFLEXION MEDICAL INC CVT                          | CUSIP: TC70GKL85<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1123437 | NS      | $2663157.96    | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | VIVIDION THERAPEUTICS MILESTONE PAYMENT            | CUSIP: TC6TYXRT3<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2328482 | NS      | $1048981.06    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Gyroscope Therapeutics Ltd                      | GYROSCOPE THERAPEUTICS MILESTONE PAYMENT 3 PP      | CUSIP: 000000000<br>LEI: 21380066POJ2YSHZAD73 | Long             | EC               | CORP              | US        |   3788007 | NS      | $984881.82     | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| PAX Labs Inc                                    | PAX LABS CLASS A COMMON PP                         | CUSIP: 000000000<br>LEI: 549300FKJA0AEKUHVG68 | Long             | EC               | CORP              | US        |   8397988 | NS      | $5542672.08    | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | RING THERAPEUTICS SER C CVT PFD STK PP             | CUSIP: TC6IOH633<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    479818 | NS      | $4414325.60    | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | Ginkgo Bioworks Holdings Earn Out Shares $20.00 PP | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    212706 | NS      | $92672.18      | 0.00%             |  |  |  | Yes           |                  2 | On Loan: No      |
| N/A                                             | CHROMA MEDICINE SERIES A CVT PFD STOCK P           | CUSIP: TC5E9TJR7<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   5207526 | NS      | $11039955.12   | 0.07%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | GENERATE BIO SER B CVT PFD STOCK PP                | CUSIP: TC5CQ34B0<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1864632 | NS      | $22095889.20   | 0.14%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Freenome Inc                                    | FREENOME HOLDINGS SER D CVT PFD PP                 | CUSIP: 000000000<br>LEI: 254900QDTSQ6S0QOCS43 | Long             | EP               | CORP              | US        |    526504 | NS      | $6144301.68    | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Exact Sciences Corp                             | - EXACT SCIENCES CMO MILESTONE PP                  | CUSIP: 000000000<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |   3726272 | NS      | $1974924.00    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | PROGNOMIQ SER B CVT PFD STOCK                      | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   3734140 | NS      | $11426468.40   | 0.07%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | FOG PHARMACEUTICALS SERIES C CVT PFD STOCK PP      | CUSIP: TC4W1BVL4<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    431391 | NS      | $4643104.47    | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Verily Life Sciences LLC                        | VERILY LIFE SCIENCES LLC SER B UNITS PP            | CUSIP: 000000000<br>LEI: 5493003ZYK1Z7M670M44 | Long             | EC               | CORP              | US        |    113564 | NS      | $17108416.60   | 0.11%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | COLOR HEALTH SERIES E CVT PFD STOCK PP             | CUSIP: TC4SC4HB5<br>LEI: N/A                  | Long             | EP               | CORP              | US        |     44149 | NS      | $1805694.10    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | LUMICKS TECH SER D CVT PFD STOCK PP                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |      4954 | NS      | $9585395.52    | 0.06%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | SALUDA MEDICAL WTS 1/23 PP                         | CUSIP: TC4G9B837<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    207185 | NS      | $0.00          | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | ODYSSEY THERAPEUTICS SR B CVT PFD STK PP           | CUSIP: TC4CBMMO7<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1115915 | NS      | $7047940.59    | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | SALIOGEN THERA SERIES B CVT PFD STOCK PP           | CUSIP: TC46G6E19<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    104129 | NS      | $11023512.46   | 0.07%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | SALUDA MEDICAL SERIES D CVT PFD STOCK PP           | CUSIP: TC460A8T3<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    690617 | NS      | $8809434.48    | 0.05%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | Series A-5 CVT Pfd                                 | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    513797 | NS      | $1572218.82    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| DNA Script SAS                                  | DNA SCRIPT SERIES C CVT PFD STOCK PP               | CUSIP: TC3XW4UW2<br>LEI: 8945001SCRZOZAUEFH64 | Long             | EP               | CORP              | FR        |     25201 | NS      | $20232307.84   | 0.12%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | NUTCRACKER THERA SER C CVT PFD STOCK PP            | CUSIP: TC3WVBUQ2<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1027785 | NS      | $11050024.87   | 0.07%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | SCRIBE THERA SER B CVT PFD STOCK PP                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1027755 | NS      | $6219253.83    | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | COLOR HEALTH SERIES D-1 CVT PFD STOCK PP           | CUSIP: TC3KSMZE0<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    438696 | NS      | $17942666.40   | 0.11%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | INSITRO SER C CVT PFD PP                           | CUSIP: TC3HHHWL7<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    588382 | NS      | $10762154.00   | 0.07%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Freenome Inc                                    | FREENOME HOLDINGS SER B CVT PFD PP                 | CUSIP: 000000000<br>LEI: 254900QDTSQ6S0QOCS43 | Long             | EP               | CORP              | US        |   1558570 | NS      | $18188511.90   | 0.11%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | VIVIDION THERAPEUTICS MILESTONE PAYMENT            | CUSIP: TC3B3UJ15<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1746361 | NS      | $828823.10     | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | TEMPUS LABS INC CVT PFD SR D PP                    | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    946886 | NS      | $55752647.68   | 0.34%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | CLEAR LABS SERIES C CVT PFD PP                     | CUSIP: TC385IBS6<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   3830773 | NS      | $13293931.54   | 0.08%             |  |  |  | Yes           |                  3 | On Loan: No      |
| REFLEXION MEDICAL INC                           | REFLEXION MEDICAL INC CVT PFD SR C PP              | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   2507885 | NS      | $5945054.25    | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | Acerta Future Payments PP                          | CUSIP: TC30M7746<br>LEI: N/A                  | Long             | EC               | CORP              | US        |  16465269 | NS      | $14440040.85   | 0.09%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | FOG PHARMA SER D CVT PFD STOCK PP                  | CUSIP: TC2VY7UZ1<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    615203 | NS      | $6621491.41    | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | HONOR TECHNOLOGY SER E CVT PFD STOCK PP            | CUSIP: TC2V4FT13<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   2095807 | NS      | $4820356.10    | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | CAPSULE CORP PP                                    | CUSIP: TC2P3HTV7<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    853213 | NS      | $2501193.91    | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Gyroscope Therapeutics Ltd                      | GYROSCOPE THERAPEUTICS MILESTONE PAYMENT 2 PP      | CUSIP: 000000000<br>LEI: 21380066POJ2YSHZAD73 | Long             | EC               | CORP              | US        |   3788007 | NS      | $1022761.89    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Scholar Rock Holding Corp                       | SCHOLAR ROCK WTS 12.25 PP                          | CUSIP: TC2K72CM5<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |    151540 | NS      | $768632.85     | 0.00%             |  |  |  | Yes           |                  2 | On Loan: No      |
| N/A                                             | AFFINIVAX AFX3772 MILESTONE EVENT PP               | CUSIP: TC2HD0ET2<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   7349672 | NS      | $4409803.21    | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | KARDIUM INC SER D-5 CVT PFD STOCK PP               | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   8849057 | NS      | $8989226.06    | 0.06%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | TEMPUS LABS SERIES G-2 CVT PFD STOCK PP            | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    117271 | NS      | $6591802.91    | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | Prime Medicine Restricted Common Stock             | CUSIP: TC21UGON5<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    522748 | NS      | $9227024.95    | 0.06%             |  |  |  | Yes           |                  2 | On Loan: No      |
| N/A                                             | CHROMACODE INC SR D-2 CVT PFD STOCK PP             | CUSIP: TC1YLODP4<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   2605184 | NS      | $1693369.60    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | Ginkgo Bioworks Holdings Earn Out Shares $17.50 PP | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    212706 | NS      | $101623.06     | 0.00%             |  |  |  | Yes           |                  2 | On Loan: No      |
| N/A                                             | NATIONAL RESILIENCE SER C CVT PFD STOCK            | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    426855 | NS      | $25922904.15   | 0.16%             |  |  |  | Yes           |                  3 | On Loan: No      |
| SomaLogic Inc                                   | SOMALOGIC INC EARN OUT SHS $20 PP                  | CUSIP: TC1RC2ZS7<br>LEI: 549300D3W3Q8CN30YO25 | Long             | EC               | CORP              | US        |   3873442 | NS      | $13611.28      | 0.00%             |  |  |  | Yes           |                  2 | On Loan: No      |
| N/A                                             | DYNAMICS SPECIAL PURPOSE CORP                      | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    115996 | NS      | $155376.64     | 0.00%             |  |  |  | Yes           |                  2 | On Loan: No      |
| N/A                                             | NATIONAL RESILIENCE SER B CVT PFD STOCK            | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1204832 | NS      | $73169447.36   | 0.45%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | COLOR HEALTH SER D CVT PFD STOCK PP                | CUSIP: TC1HL9RU8<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    296922 | NS      | $12144109.80   | 0.07%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | CLEERLY SER C CVT PFD STK PP                       | CUSIP: TC1A1CZJ4<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    586029 | NS      | $6903773.24    | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | INSITRO SER B CVT PFD PP                           | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    883580 | NS      | $16161650.14   | 0.10%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | LARONDE SERIES B CVT PFD STOCK PP                  | CUSIP: TC14DLDG5<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1169887 | NS      | $6551367.20    | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | CARIS LIFE SER D CVT PFD STOCK PP                  | CUSIP: TC13PNHL5<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   2280334 | NS      | $15004597.72   | 0.09%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | CELLANOME SERIES A CVT PFD STOCK PP                | CUSIP: TC13MXKE8<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1993387 | NS      | $13873973.52   | 0.09%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Exact Sciences Corp                             | EXACT SCIENCES EXPENSE FUND PP                     | CUSIP: 000000000<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |      3795 | NS      | $3415.57       | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | CARIS LIFE SCIENCES SER C CVT PFD PP               | CUSIP: TC104V422<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   3758668 | NS      | $24732035.44   | 0.15%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | Ginkgo Bioworks Holdings Earn Out Shares $15.00 PP | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    212706 | NS      | $112407.25     | 0.00%             |  |  |  | Yes           |                  2 | On Loan: No      |
| N/A                                             | TREELINE BIO SER A CVT PFD STOCK PP                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   2370150 | NS      | $18552349.13   | 0.11%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | DELFI DIAGNOSTICS SR A CVT PFD STOCK PP            | CUSIP: TC0LOSSE0<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   3426868 | NS      | $16605094.51   | 0.10%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | END EAVOR BIO SERIES B CVT PFD STOCK PP            | CUSIP: TC0KH48I6<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1867734 | NS      | $8808420.32    | 0.05%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | KARDIUM SERIES D6 CVT PFD STOCK PP                 | CUSIP: TC0GUUWU8<br>LEI: N/A                  | Long             | EP               | CORP              | US        |  12320393 | NS      | $12515548.03   | 0.08%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | CHROMACODE INC SR D-1 CVT PFD STOCK PP             | CUSIP: TC0GJI1L2<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   3137582 | NS      | $2039428.30    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | VIVIDION THERAPEUTICS MILESTONE PAYMENT 3          | CUSIP: TC09CIJA0<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1746361 | NS      | $746918.75     | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | GENESIS THERA SER A CVT PFD STOCK PP               | CUSIP: TC08XH789<br>LEI: N/A                  | Long             | EP               | CORP              | US        |    829412 | NS      | $4236304.73    | 0.03%             |  |  |  | Yes           |                  3 | On Loan: No      |
| N/A                                             | PROGNOMIQ SER C CVT PFD STOCK PP                   | CUSIP: 000000000<br>LEI: N/A                  | Long             | EP               | CORP              | US        |   1143244 | NS      | $3498326.64    | 0.02%             |  |  |  | Yes           |                  3 | On Loan: No      |
| Novocure Ltd                                    | NOVOCURE LTD                                       | CUSIP: 000000000<br>LEI: 213800YPP55UMHWA4826 | Long             | EC               | CORP              | JE        |   1176250 | NS      | $86277937.50   | 0.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Sophia Genetics SA                              | SOPHIA GENETICS SA                                 | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | CH        |    635323 | NS      | $1308765.38    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Health Sciences Acquisitions Corp 2             | HEALTH SCIENCES ACQUISITIONS CORP 2                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |    562163 | NS      | $5616008.37    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Royalty Pharma PLC                              | ROYALTY PHARMA PLC                                 | CUSIP: 000000000<br>LEI: 549300FGFN7VOK8BZR03 | Long             | EC               | CORP              | GB        |   1671948 | NS      | $66075384.96   | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Wuxi Biologics Cayman Inc                       | WUXI BIOLOGICS CAYMAN INC                          | CUSIP: 000000000<br>LEI: 5493001TD2TH6VDTJU11 | Long             | EC               | CORP              | KY        |   3159500 | NS      | $23929771.61   | 0.15%             |  |  |  | No            |                  2 | On Loan: No      |
| ADC Therapeutics SA                             | ADC THERAPEUTICS SA                                | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | CH        |   1173088 | NS      | $4504657.92    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| MeiraGTx Holdings plc                           | MEIRAGTX HOLDINGS PLC                              | CUSIP: 000000000<br>LEI: 54930007YV6NYIOGFZ57 | Long             | EC               | CORP              | KY        |    207581 | NS      | $1353428.12    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| STERIS PLC                                      | STERIS PLC                                         | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | IE        |    223989 | NS      | $41368528.41   | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| CRISPR Therapeutics AG                          | CRISPR THERAPEUTICS AG                             | CUSIP: 000000000<br>LEI: 506700O6IRRIQLT3W370 | Long             | EC               | CORP              | CH        |    260117 | NS      | $10573756.05   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Prothena Corp PLC                               | PROTHENA CORP PLC                                  | CUSIP: 000000000<br>LEI: 5299009ZXQ8NIIJ8OL30 | Long             | EC               | CORP              | IE        |    649910 | NS      | $39157077.50   | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Daiichi Sankyo Co Ltd                           | DAIICHI SANKYO CO LTD                              | CUSIP: 000000000<br>LEI: 353800XGIU2IHQGC9504 | Long             | EC               | CORP              | JP        |   3996200 | NS      | $128624452.23  | 0.79%             |  |  |  | No            |                  2 | On Loan: No      |
| Zimmer Biomet Holdings Inc                      | ZIMMER BIOMET HOLDINGS INC                         | CUSIP: 98956P102<br>LEI: 2P2YLDVPES3BXQ1FRB91 | Long             | EC               | CORP              | US        |    447573 | NS      | $57065557.50   | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Zentalis Pharmaceuticals Inc                    | ZENTALIS PHARMACEUTICALS INC                       | CUSIP: 98943L107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    582982 | NS      | $11741257.48   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Zai Lab Ltd                                     | ZAI LAB LTD                                        | CUSIP: 98887Q104<br>LEI: 549300P2UYQ9U5LY1T58 | Long             | EC               | CORP              | KY        |    438090 | NS      | $13449363.00   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Xencor Inc                                      | XENCOR INC                                         | CUSIP: 98401F105<br>LEI: 549300V5IF65437JKG30 | Long             | EC               | CORP              | US        |    762860 | NS      | $19864874.40   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| West Pharmaceutical Services Inc                | WEST PHARMACEUTICAL SERVICES INC                   | CUSIP: 955306105<br>LEI: 5493007NKRGM1RJQ1P16 | Long             | EC               | CORP              | US        |    348364 | NS      | $81987467.40   | 0.51%             |  |  |  | No            |                  1 | On Loan: No      |
| Waters Corp                                     | WATERS CORP                                        | CUSIP: 941848103<br>LEI: 5T547R1474YC9HOD8Q74 | Long             | EC               | CORP              | US        |     69620 | NS      | $23850419.60   | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Warby Parker Inc                                | WARBY PARKER INC                                   | CUSIP: 93403J106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1562906 | NS      | $21083601.94   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals Inc                      | VERTEX PHARMACEUTICALS INC                         | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |   1254616 | NS      | $362308008.48  | 2.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Veeva Systems Inc                               | VEEVA SYSTEMS INC                                  | CUSIP: 922475108<br>LEI: 549300YZEXPDB92M2F02 | Long             | EC               | CORP              | US        |    579779 | NS      | $93564735.02   | 0.58%             |  |  |  | No            |                  1 | On Loan: No      |
| UnitedHealth Group Inc                          | UNITEDHEALTH GROUP INC                             | CUSIP: 91324P102<br>LEI: 549300GHBMY8T5GXDE41 | Long             | EC               | CORP              | US        |   2644430 | NS      | $1402023897.40 | 8.65%             |  |  |  | No            |                  1 | On Loan: No      |
| Ultragenyx Pharmaceutical Inc                   | ULTRAGENYX PHARMACEUTICAL INC                      | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |   1346360 | NS      | $62376858.80   | 0.38%             |  |  |  | No            |                  1 | On Loan: No      |
| Twist Bioscience Corp                           | TWIST BIOSCIENCE CORP                              | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |    298281 | NS      | $7102070.61    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Theseus Pharmaceuticals Inc                     | THESEUS PHARMACEUTICALS INC                        | CUSIP: 88369M101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1009115 | NS      | $5025392.70    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Thermo Fisher Scientific Inc                    | THERMO FISHER SCIENTIFIC INC                       | CUSIP: 883556102<br>LEI: HCHV7422L5HDJZCRFL38 | Long             | EC               | CORP              | US        |   1503088 | NS      | $827735530.72  | 5.11%             |  |  |  | No            |                  1 | On Loan: No      |
| 10X Genomics Inc                                | 10X GENOMICS INC                                   | CUSIP: 88025U109<br>LEI: 5493003Z6741WNLG7H43 | Long             | EC               | CORP              | US        |   1243729 | NS      | $45321484.76   | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Tenaya Therapeutics Inc                         | TENAYA THERAPEUTICS INC                            | CUSIP: 87990A106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1170563 | NS      | $2352831.63    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Teleflex Inc                                    | TELEFLEX INC                                       | CUSIP: 879369106<br>LEI: UUL85LWXB4NGSWWXIQ25 | Long             | EC               | CORP              | US        |    310808 | NS      | $77587001.04   | 0.48%             |  |  |  | No            |                  1 | On Loan: No      |
| Surgery Partners Inc                            | SURGERY PARTNERS INC                               | CUSIP: 86881A100<br>LEI: 549300LC82HG33S19I03 | Long             | EC               | CORP              | US        |    322715 | NS      | $8990839.90    | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Stryker Corp                                    | STRYKER CORP                                       | CUSIP: 863667101<br>LEI: 5493002F0SC4JTBU5137 | Long             | EC               | CORP              | US        |   1500949 | NS      | $366967021.01  | 2.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Stoke Therapeutics Inc                          | STOKE THERAPEUTICS INC                             | CUSIP: 86150R107<br>LEI: 549300RD25SS2DIJHJ67 | Long             | EC               | CORP              | US        |    255805 | NS      | $2361080.15    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| SpringWorks Therapeutics Inc                    | SPRINGWORKS THERAPEUTICS INC                       | CUSIP: 85205L107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    159530 | NS      | $4149375.30    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| SomaLogic Inc                                   | SOMALOGIC INC                                      | CUSIP: 83444K113<br>LEI: 549300D3W3Q8CN30YO25 | Long             | EC               | CORP              | US        |    103068 | NS      | $41227.20      | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Shockwave Medical Inc                           | SHOCKWAVE MEDICAL INC                              | CUSIP: 82489T104<br>LEI: 549300LDXO56IC5Y1538 | Long             | EC               | CORP              | US        |    559582 | NS      | $115055655.02  | 0.71%             |  |  |  | No            |                  1 | On Loan: No      |
| Senti Biosciences Inc                           | SENTI BIOSCIENCES INC                              | CUSIP: 81726A100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1266785 | NS      | $1786166.85    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Sema4 Holdings Corp                             | GENEDX HOLDINGS CORP                               | CUSIP: 81663L119<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    236011 | NS      | $4484.21       | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Sema4 Holdings Corp                             | GENEDX HOLDINGS CORP                               | CUSIP: 81663L101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1150482 | NS      | $303497.15     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Seer Inc                                        | SEER INC                                           | CUSIP: 81578P106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    939085 | NS      | $5446693.00    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Seagen Inc                                      | SEAGEN INC                                         | CUSIP: 81181C104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    463072 | NS      | $59509382.72   | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Scholar Rock Holding Corp                       | SCHOLAR ROCK HOLDING CORP                          | CUSIP: 80706P103<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |   1843863 | NS      | $16686960.15   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Sarepta Therapeutics Inc                        | SAREPTA THERAPEUTICS INC                           | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |    456820 | NS      | $59194735.60   | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Sana Biotechnology Inc                          | SANA BIOTECHNOLOGY INC                             | CUSIP: 799566104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1608120 | NS      | $6352074.00    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Sage Therapeutics Inc                           | SAGE THERAPEUTICS INC                              | CUSIP: 78667J108<br>LEI: 5493000JX4BJS9W6CN35 | Long             | EC               | CORP              | US        |    550322 | NS      | $20989281.08   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Rocket Pharmaceuticals Inc                      | ROCKET PHARMACEUTICALS INC                         | CUSIP: 77313F106<br>LEI: 549300R7VV82YUIN4Y93 | Long             | EC               | CORP              | US        |    468255 | NS      | $9163750.35    | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| REVOLUTION Medicines Inc                        | REVOLUTION MEDICINES INC                           | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |   1007238 | NS      | $23992409.16   | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| T Rowe Price Government Reserve Investment Fund | T ROWE PRICE GOVERNMENT RESERVE INVESTMENT FUND    | CUSIP: 76105Y109<br>LEI: 5493007QR86JJLYO6D96 | Long             | STIV             | RF                | US        | 158748773 | NS      | $158748773.19  | 0.98%             |  |  |  | No            |                  1 | On Loan: No      |
| Replimune Group Inc                             | REPLIMUNE GROUP INC                                | CUSIP: 76029N106<br>LEI: 549300AY704NEIRC4K64 | Long             | EC               | CORP              | US        |   1354276 | NS      | $36836307.20   | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Repligen Corp                                   | REPLIGEN CORP                                      | CUSIP: 759916109<br>LEI: 54930006QJ0T5AUO1E71 | Long             | EC               | CORP              | US        |    215920 | NS      | $36557415.20   | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Relay Therapeutics Inc                          | RELAY THERAPEUTICS INC                             | CUSIP: 75943R102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1045229 | NS      | $15615721.26   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| REGENXBIO Inc                                   | REGENXBIO INC                                      | CUSIP: 75901B107<br>LEI: 549300EOES47LATSET33 | Long             | EC               | CORP              | US        |    108057 | NS      | $2450732.76    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Regeneron Pharmaceuticals Inc                   | REGENERON PHARMACEUTICALS INC                      | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |    681567 | NS      | $491743774.83  | 3.03%             |  |  |  | No            |                  1 | On Loan: No      |
| RAPT Therapeutics Inc                           | RAPT THERAPEUTICS INC                              | CUSIP: 75382E109<br>LEI: 549300MB473BIU78ES48 | Long             | EC               | CORP              | US        |    680443 | NS      | $13472771.40   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Rapid Micro Biosystems Inc                      | RAPID MICRO BIOSYSTEMS INC                         | CUSIP: 75340L104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    583246 | NS      | $659067.98     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Quanterix Corp                                  | QUANTERIX CORP                                     | CUSIP: 74766Q101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    114664 | NS      | $1588096.40    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                             | PROGENIC PHARMACEUTICALS CVR                       | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    842223 | NS      | $969314.45     | 0.01%             |  |  |  | No            |                  3 | On Loan: No      |
| PROCEPT BioRobotics Corp                        | PROCEPT BIOROBOTICS CORP                           | CUSIP: 74276L105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    668997 | NS      | $27790135.38   | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Prelude Therapeutics Inc                        | PRELUDE THERAPEUTICS INC                           | CUSIP: 74065P101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    181040 | NS      | $1093481.60    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Pfizer Inc                                      | PFIZER INC                                         | CUSIP: 717081103<br>LEI: 765LHXWGK1KXCLTFYQ30 | Long             | EC               | CORP              | US        |   7123092 | NS      | $364987234.08  | 2.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Roche Holding AG                                | ROCHE HOLDING AG                                   | CUSIP: 000000000<br>LEI: 549300U41AUUVOAAOB37 | Long             | EC               | CORP              | CH        |    392064 | NS      | $123201233.03  | 0.76%             |  |  |  | No            |                  2 | On Loan: No      |
| Penumbra Inc                                    | PENUMBRA INC                                       | CUSIP: 70975L107<br>LEI: 549300RGE06P3ECANU72 | Long             | EC               | CORP              | US        |    667835 | NS      | $148566574.10  | 0.92%             |  |  |  | No            |                  1 | On Loan: No      |
| Pacific Biosciences of California Inc           | PACIFIC BIOSCIENCES OF CALIFORNIA INC              | CUSIP: 69404D108<br>LEI: 529900F1BWRE1M0KZN89 | Long             | EC               | CORP              | US        |   2592999 | NS      | $21210731.82   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC Therapeutics Inc                            | PTC THERAPEUTICS INC                               | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |    203485 | NS      | $7767022.45    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Option Care Health Inc                          | OPTION CARE HEALTH INC                             | CUSIP: 68404L201<br>LEI: 549300DI3Q5ACSYJRI17 | Long             | EC               | CORP              | US        |    622214 | NS      | $18722419.26   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Olink Holding AB                                | OLINK HOLDING AB                                   | CUSIP: 680710100<br>LEI: 8945004Z7ZHV3LML4J27 | Long             | EC               | CORP              | SE        |   1944081 | NS      | $49340775.78   | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Oak Street Health Inc                           | OAK STREET HEALTH INC                              | CUSIP: 67181A107<br>LEI: 2549007CJE6GSEURLA30 | Long             | EC               | CORP              | US        |    512163 | NS      | $11016626.13   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Nurix Therapeutics Inc                          | NURIX THERAPEUTICS INC                             | CUSIP: 67080M103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    274027 | NS      | $3008816.46    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Nevro Corp                                      | NEVRO CORP                                         | CUSIP: 64157F103<br>LEI: 254900SH91I4BOYKUE38 | Long             | EC               | CORP              | US        |    176893 | NS      | $7004962.80    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences Inc                      | NEUROCRINE BIOSCIENCES INC                         | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |    343178 | NS      | $40989180.32   | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Morphic Holding Inc                             | MORPHIC HOLDING INC                                | CUSIP: 61775R105<br>LEI: 549300RWWOUFLHTY1224 | Long             | EC               | CORP              | US        |    185013 | NS      | $4949097.75    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| MoonLake Immunotherapeutics                     | MOONLAKE IMMUNOTHERAPEUTICS                        | CUSIP: 61559X104<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |    678545 | NS      | $7124722.50    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Monte Rosa Therapeutics Inc                     | MONTE ROSA THERAPEUTICS INC                        | CUSIP: 61225M102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1153343 | NS      | $8776940.23    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Molina Healthcare Inc                           | MOLINA HEALTHCARE INC                              | CUSIP: 60855R100<br>LEI: 549300NQQCEQ46YHZ591 | Long             | EC               | CORP              | US        |    759446 | NS      | $250784258.12  | 1.55%             |  |  |  | No            |                  1 | On Loan: No      |
| Moderna Inc                                     | MODERNA INC                                        | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |   1045625 | NS      | $187815162.50  | 1.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Mirati Therapeutics Inc                         | MIRATI THERAPEUTICS INC                            | CUSIP: 60468T105<br>LEI: 529900GYRW59IDQV6N54 | Long             | EC               | CORP              | US        |    584574 | NS      | $26487047.94   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Mettler-Toledo International Inc                | METTLER-TOLEDO INTERNATIONAL INC                   | CUSIP: 592688105<br>LEI: 5493000BD5GJNUDIUG10 | Long             | EC               | CORP              | US        |     50097 | NS      | $72412708.65   | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Merck & Co Inc                                  | MERCK & CO INC                                     | CUSIP: 58933Y105<br>LEI: 4YV9Y5M8S0BRK1RP0397 | Long             | EC               | CORP              | US        |   5109928 | NS      | $566946511.60  | 3.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Sartorius AG                                    | SARTORIUS AG                                       | CUSIP: 000000000<br>LEI: 529900EQV2DY4FOAMU38 | Long             | EP               | CORP              | DE        |    240070 | NS      | $94797884.64   | 0.59%             |  |  |  | No            |                  2 | On Loan: No      |
| Evotec SE                                       | EVOTEC SE                                          | CUSIP: 000000000<br>LEI: 529900F9KI6OYITO9B12 | Long             | EC               | CORP              | DE        |    389789 | NS      | $6341137.80    | 0.04%             |  |  |  | No            |                  2 | On Loan: No      |
| Lyell Immunopharma Inc                          | LYELL IMMUNOPHARMA INC                             | CUSIP: 55083R104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1295155 | NS      | $4494187.85    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Longboard Pharmaceuticals Inc                   | LONGBOARD PHARMACEUTICALS INC                      | CUSIP: 54300N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    503417 | NS      | $1590797.72    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Eli Lilly & Co                                  | ELI LILLY & CO                                     | CUSIP: 532457108<br>LEI: FRDRIPF3EKNDJ2CQJL29 | Long             | EC               | CORP              | US        |   1981704 | NS      | $724986591.36  | 4.47%             |  |  |  | No            |                  1 | On Loan: No      |
| LianBio                                         | LIANBIO                                            | CUSIP: 53000N108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2115865 | NS      | $3470018.60    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Lantheus Holdings Inc                           | LANTHEUS HOLDINGS INC                              | CUSIP: 516544103<br>LEI: 5299005HUB5IOJGO7S39 | Long             | EC               | CORP              | US        |    126300 | NS      | $6436248.00    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Kymera Therapeutics Inc                         | KYMERA THERAPEUTICS INC                            | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    775316 | NS      | $19351887.36   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Kronos Bio Inc                                  | KRONOS BIO INC                                     | CUSIP: 50107A104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    111866 | NS      | $181222.92     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Kodiak Sciences Inc                             | KODIAK SCIENCES INC                                | CUSIP: 50015M109<br>LEI: 254900IXI5NI8C9OQE24 | Long             | EC               | CORP              | US        |    311256 | NS      | $2228592.96    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Karuna Therapeutics Inc                         | KARUNA THERAPEUTICS INC                            | CUSIP: 48576A100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    601875 | NS      | $118268437.50  | 0.73%             |  |  |  | No            |                  1 | On Loan: No      |
| IVERIC bio Inc                                  | IVERIC BIO INC                                     | CUSIP: 46583P102<br>LEI: 549300GZXI59U71XPM70 | Long             | EC               | CORP              | US        |   1835482 | NS      | $39297669.62   | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Iovance Biotherapeutics Inc                     | IOVANCE BIOTHERAPEUTICS INC COM                    | CUSIP: 462260100<br>LEI: 549300220Z2GHH33XL82 | Long             | EC               | CORP              | US        |   1231161 | NS      | $7867118.79    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Ionis Pharmaceuticals Inc                       | IONIS PHARMACEUTICALS INC                          | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |   1181634 | NS      | $44630316.18   | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Intuitive Surgical Inc                          | INTUITIVE SURGICAL INC                             | CUSIP: 46120E602<br>LEI: 54930052SRG011710797 | Long             | EC               | CORP              | US        |   1815497 | NS      | $481742128.95  | 2.97%             |  |  |  | No            |                  1 | On Loan: No      |
| Genmab A/S                                      | GENMAB A/S                                         | CUSIP: 000000000<br>LEI: 529900MTJPDPE4MHJ122 | Long             | EC               | CORP              | DK        |    313129 | NS      | $132389308.75  | 0.82%             |  |  |  | No            |                  2 | On Loan: No      |
| Intellia Therapeutics Inc                       | INTELLIA THERAPEUTICS INC                          | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |    382509 | NS      | $13345739.01   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Insulet Corp                                    | INSULET CORP                                       | CUSIP: 45784P101<br>LEI: 549300TZTYD2PYN92D43 | Long             | EC               | CORP              | US        |    432380 | NS      | $127288348.20  | 0.79%             |  |  |  | No            |                  1 | On Loan: No      |
| Insmed Inc                                      | INSMED INC                                         | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |   2406290 | NS      | $48077674.20   | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Incyte Corp                                     | INCYTE CORP                                        | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |    887613 | NS      | $71293076.16   | 0.44%             |  |  |  | No            |                  1 | On Loan: No      |
| Inari Medical Inc                               | INARI MEDICAL INC                                  | CUSIP: 45332Y109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    382006 | NS      | $24280301.36   | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Immunocore Holdings PLC                         | IMMUNOCORE HOLDINGS PLC                            | CUSIP: 45258D105<br>LEI: 213800IUE3DFS84BVN18 | Long             | EC               | CORP              | GB        |   1055554 | NS      | $60240466.78   | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Immuneering Corp                                | IMMUNEERING CORP                                   | CUSIP: 45254E107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1582394 | NS      | $7674610.90    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Ideaya Biosciences Inc                          | IDEAYA BIOSCIENCES INC                             | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |    134265 | NS      | $2439595.05    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| iRhythm Technologies Inc                        | IRHYTHM TECHNOLOGIES INC                           | CUSIP: 450056106<br>LEI: 549300FJI72RJGDQS384 | Long             | EC               | CORP              | US        |    180858 | NS      | $16940968.86   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| IGM Biosciences Inc                             | IGM BIOSCIENCES INC                                | CUSIP: 449585108<br>LEI: 5493008XCQES2N0VY969 | Long             | EC               | CORP              | US        |    304853 | NS      | $5185549.53    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Humana Inc                                      | HUMANA INC                                         | CUSIP: 444859102<br>LEI: 529900YLDW34GJAO4J06 | Long             | EC               | CORP              | US        |    701570 | NS      | $359337138.30  | 2.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Hologic Inc                                     | HOLOGIC INC                                        | CUSIP: 436440101<br>LEI: 549300DYP6F5ZJL0LB74 | Long             | EC               | CORP              | US        |   1954618 | NS      | $146224972.58  | 0.90%             |  |  |  | No            |                  1 | On Loan: No      |
| HCA Healthcare Inc                              | HCA HEALTHCARE INC                                 | CUSIP: 40412C101<br>LEI: 529900PH4ZGUH2MNEU89 | Long             | EC               | CORP              | US        |    608498 | NS      | $146015180.08  | 0.90%             |  |  |  | No            |                  1 | On Loan: No      |
| Guardant Health Inc                             | GUARDANT HEALTH INC                                | CUSIP: 40131M109<br>LEI: 254900M8C3E5VC8BR186 | Long             | EC               | CORP              | US        |   1092484 | NS      | $29715564.80   | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Ginkgo Bioworks Holdings Inc                    | GINKGO BIOWORKS HOLDINGS INC                       | CUSIP: 37611X100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2329124 | NS      | $3936219.56    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Generation Bio Co                               | GENERATION BIO CO                                  | CUSIP: 37148K100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1783502 | NS      | $7009162.86    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| GE HealthCare Technologies Inc                  | GE HEALTHCARE TECHNOLOGIES INC                     | CUSIP: 36266G107<br>LEI: 549300OI9J7XOWZMUN85 | Long             | EC               | CORP              | US        |    177056 | NS      | $10336529.28   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Fate Therapeutics Inc                           | FATE THERAPEUTICS INC                              | CUSIP: 31189P102<br>LEI: 549300L14Q4UHOODLA90 | Long             | EC               | CORP              | US        |    761472 | NS      | $7683252.48    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| F-star Therapeutics Inc                         | F-STAR THERAPEUTICS INC                            | CUSIP: 30315R107<br>LEI: 5493003TRY5HK3M6WH76 | Long             | EC               | CORP              | US        |     43784 | NS      | $276714.88     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Exscientia Plc                                  | EXSCIENTIA LTD                                     | CUSIP: 30223G102<br>LEI: 213800XOQHH5CV85AD30 | Long             | EC               | CORP              | GB        |    192196 | NS      | $1024404.68    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Exelixis Inc                                    | EXELIXIS INC                                       | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |   2022529 | NS      | $32441365.16   | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Exact Sciences Corp                             | EXACT SCIENCES CORP                                | CUSIP: 30063P105<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |    952069 | NS      | $47136936.19   | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Entrada Therapeutics Inc                        | ENTRADA THERAPEUTICS INC                           | CUSIP: 29384C108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    667462 | NS      | $9024086.24    | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Enanta Pharmaceuticals Inc                      | ENANTA PHARMACEUTICALS INC                         | CUSIP: 29251M106<br>LEI: 529900SSN4DODDQSN594 | Long             | EC               | CORP              | US        |    126726 | NS      | $5895293.52    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Elanco Animal Health Inc                        | ELANCO ANIMAL HEALTH INC                           | CUSIP: 28414H103<br>LEI: 549300SHPNDCE059M934 | Long             | EC               | CORP              | US        |    625900 | NS      | $7648498.00    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| EQRx Inc                                        | EQRX INC                                           | CUSIP: 26886C115<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    227520 | NS      | $60952.61      | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| EQRx Inc                                        | EQRX INC                                           | CUSIP: 26886C107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    896285 | NS      | $2204861.10    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Doximity Inc                                    | DOXIMITY INC                                       | CUSIP: 26622P107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1255648 | NS      | $42139546.88   | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Dexcom Inc                                      | DEXCOM INC                                         | CUSIP: 252131107<br>LEI: 549300YSK3QDSFR5EU59 | Long             | EC               | CORP              | US        |   1148997 | NS      | $130112420.28  | 0.80%             |  |  |  | No            |                  1 | On Loan: No      |
| Denali Therapeutics Inc                         | DENALI THERAPEUTICS INC                            | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |   1071059 | NS      | $29786150.79   | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Day One Biopharmaceuticals Inc                  | DAY ONE BIOPHARMACEUTICALS INC                     | CUSIP: 23954D109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    474062 | NS      | $10201814.24   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Danaher Corp                                    | DANAHER CORP                                       | CUSIP: 235851102<br>LEI: S4BKK9OTCEWQ3YHPFM11 | Long             | EC               | CORP              | US        |   2316190 | NS      | $614763149.80  | 3.79%             |  |  |  | No            |                  1 | On Loan: No      |
| DICE Therapeutics Inc                           | DICE THERAPEUTICS INC                              | CUSIP: 23345J104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    678522 | NS      | $21169886.40   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytokinetics Inc                                | CYTOKINETICS INC                                   | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |    427378 | NS      | $19582459.96   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Cooper Cos Inc/The                              | COOPER COS INC/THE                                 | CUSIP: 216648402<br>LEI: QJKMVPIGLH7530PCUE20 | Long             | EC               | CORP              | US        |    108118 | NS      | $35751379.06   | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Certara Inc                                     | CERTARA INC                                        | CUSIP: 15687V109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    461617 | NS      | $7418185.19    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Cerevel Therapeutics Holdings Inc               | CEREVEL THERAPEUTICS HOLDINGS INC                  | CUSIP: 15678U128<br>LEI: 254900RJNIRS9COSQR41 | Long             | EC               | CORP              | US        |   1633045 | NS      | $51506239.30   | 0.32%             |  |  |  | No            |                  1 | On Loan: No      |
| Centessa Pharmaceuticals PLC                    | CENTESSA PHARMACEUTICALS PLC                       | CUSIP: 152309100<br>LEI: 213800GIDAARDSKOI827 | Long             | EC               | CORP              | GB        |    891078 | NS      | $2762341.80    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Centene Corp                                    | CENTENE CORP                                       | CUSIP: 15135B101<br>LEI: 549300Z7JJ4TQSQGT333 | Long             | EC               | CORP              | US        |   3341194 | NS      | $274011319.94  | 1.69%             |  |  |  | No            |                  1 | On Loan: No      |
| Celldex Therapeutics Inc                        | CELLDEX THERAPEUTICS INC                           | CUSIP: 15117B202<br>LEI: 529900F018DMYWH38923 | Long             | EC               | CORP              | US        |    628343 | NS      | $28005247.51   | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Catalent Inc                                    | CATALENT INC                                       | CUSIP: 148806102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    958897 | NS      | $43159953.97   | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| Cigna Corp                                      | CIGNA CORP                                         | CUSIP: 125523100<br>LEI: 549300VIWYMSIGT1U456 | Long             | EC               | CORP              | US        |    711926 | NS      | $235889560.84  | 1.46%             |  |  |  | No            |                  1 | On Loan: No      |
| C4 Therapeutics Inc                             | C4 THERAPEUTICS INC                                | CUSIP: 12529R107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    444170 | NS      | $2620603.00    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Burning Rock Biotech Ltd                        | BURNING ROCK BIOTECH LTD                           | CUSIP: 12233L107<br>LEI: 5493006HO04GB8AQ2V43 | Long             | EC               | CORP              | KY        |    187049 | NS      | $420860.25     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Bruker Corp                                     | BRUKER CORP                                        | CUSIP: 116794108<br>LEI: LEBZ6VLQ6I8XB1NHVY15 | Long             | EC               | CORP              | US        |   1913218 | NS      | $130768450.30  | 0.81%             |  |  |  | No            |                  1 | On Loan: No      |
| Blueprint Medicines Corp                        | BLUEPRINT MEDICINES CORP                           | CUSIP: 09627Y109<br>LEI: 5299004CC60O9T5HVM83 | Long             | EC               | CORP              | US        |   1122964 | NS      | $49197052.84   | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| BioNTech SE                                     | BIONTECH SE                                        | CUSIP: 09075V102<br>LEI: 894500UZJ5LG1F8J1U58 | Long             | EC               | CORP              | DE        |    571641 | NS      | $85871911.02   | 0.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Bio-Techne Corp                                 | BIO-TECHNE CORP                                    | CUSIP: 09073M104<br>LEI: 54930073RLKQ51TILZ35 | Long             | EC               | CORP              | US        |    437137 | NS      | $36229914.56   | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen Inc                                      | BIOGEN INC                                         | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |    357689 | NS      | $99051237.88   | 0.61%             |  |  |  | No            |                  1 | On Loan: No      |
| Bicycle Therapeutics PLC                        | BICYCLE THERAPEUTICS PLC                           | CUSIP: 088786108<br>LEI: 213800XKUI6R7GKC3E43 | Long             | EC               | CORP              | GB        |    254670 | NS      | $7538232.00    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| BeiGene Ltd                                     | BEIGENE LTD                                        | CUSIP: 07725L102<br>LEI: 549300JFUK6FRD5MH739 | Long             | EC               | CORP              | KY        |    172720 | NS      | $37988036.80   | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Becton Dickinson and Co                         | BECTON DICKINSON AND CO                            | CUSIP: 075887109<br>LEI: ICE2EP6D98PQUILVRZ91 | Long             | EC               | CORP              | US        |   1138233 | NS      | $289452651.90  | 1.79%             |  |  |  | No            |                  1 | On Loan: No      |
| Avidity Biosciences Inc                         | AVIDITY BIOSCIENCES INC                            | CUSIP: 05370A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1761822 | NS      | $39094830.18   | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Avantor Inc                                     | AVANTOR INC                                        | CUSIP: 05352A100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   4213720 | NS      | $88867354.80   | 0.55%             |  |  |  | No            |                  1 | On Loan: No      |
| AstraZeneca PLC                                 | ASTRAZENECA PLC                                    | CUSIP: 046353108<br>LEI: PY6ZZQWO2IZFZC3IOL08 | Long             | EC               | CORP              | GB        |   7999227 | NS      | $542347590.60  | 3.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Ascendis Pharma A/S                             | ASCENDIS PHARMA A/S                                | CUSIP: 04351P101<br>LEI: 549300B66JN3W3J8GH73 | Long             | EC               | CORP              | DK        |    838598 | NS      | $102417973.74  | 0.63%             |  |  |  | No            |                  1 | On Loan: No      |
| Arvinas Inc                                     | ARVINAS INC                                        | CUSIP: 04335A105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    519755 | NS      | $17780818.55   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Argenx SE                                       | ARGENX SE                                          | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |    708841 | NS      | $268530236.03  | 1.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Apellis Pharmaceuticals Inc                     | APELLIS PHARMACEUTICALS INC                        | CUSIP: 03753U106<br>LEI: 254900HS0ZFRXXSB9D42 | Long             | EC               | CORP              | US        |    645221 | NS      | $33364377.91   | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Elevance Health Inc                             | ELEVANCE HEALTH INC                                | CUSIP: 036752103<br>LEI: 8MYN82XMYQH89CTMTH67 | Long             | EC               | CORP              | US        |    995033 | NS      | $510422078.01  | 3.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals Inc                     | ALNYLAM PHARMACEUTICALS INC                        | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |   1534426 | NS      | $364656338.90  | 2.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Allogene Therapeutics Inc                       | ALLOGENE THERAPEUTICS INC                          | CUSIP: 019770106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1862898 | NS      | $11717628.42   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Allakos Inc                                     | ALLAKOS INC                                        | CUSIP: 01671P100<br>LEI: 549300S6ZD1W6BPMDY37 | Long             | EC               | CORP              | US        |    966912 | NS      | $8141399.04    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Alignment Healthcare Inc                        | ALIGNMENT HEALTHCARE INC                           | CUSIP: 01625V104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1216902 | NS      | $14310767.52   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Alector Inc                                     | ALECTOR INC                                        | CUSIP: 014442107<br>LEI: 549300Z8RQOIY1JMHC25 | Long             | EC               | CORP              | US        |    344770 | NS      | $3182227.10    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| agilon health Inc                               | AGILON HEALTH INC                                  | CUSIP: 00857U107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    462354 | NS      | $7462393.56    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Agios Pharmaceuticals Inc                       | AGIOS PHARMACEUTICALS INC                          | CUSIP: 00847X104<br>LEI: 529900ONJHY8EOGYT555 | Long             | EC               | CORP              | US        |    398930 | NS      | $11201954.40   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Agilent Technologies Inc                        | AGILENT TECHNOLOGIES INC                           | CUSIP: 00846U101<br>LEI: QUIX8Y7A2WP0XRMW7G29 | Long             | EC               | CORP              | US        |   2165312 | NS      | $324038940.80  | 2.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Adaptive Biotechnologies Corp                   | ADAPTIVE BIOTECHNOLOGIES CORP                      | CUSIP: 00650F109<br>LEI: 549300ZTF7OT1FW66Q96 | Long             | EC               | CORP              | US        |    679353 | NS      | $5190256.92    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Invivyd Inc                                     | INVIVYD INC                                        | CUSIP: 00534A102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    288950 | NS      | $433425.00     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| ACADIA Pharmaceuticals Inc                      | ACADIA PHARMACEUTICALS INC                         | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |   1177638 | NS      | $18747996.96   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| AbbVie Inc                                      | ABBVIE INC                                         | CUSIP: 00287Y109<br>LEI: FR5LCKFTG8054YNNRU85 | Long             | EC               | CORP              | US        |   1721272 | NS      | $278174767.92  | 1.72%             |  |  |  | No            |                  1 | On Loan: No      |
| Aadi Bioscience Inc                             | AADI BIOSCIENCE INC                                | CUSIP: 00032Q104<br>LEI: 549300G3U7TKW1M58L09 | Long             | EC               | CORP              | US        |    150289 | NS      | $1928207.87    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2022-12-31

**Name of Applicant:** T. ROWE PRICE HEALTH SCIENCES FUND, INC.

**Signature:** /s/ Alan Dupski

**Name of Signer:** Alan Dupski

**Title:** Treasurer & Vice President