# EDGAR Filing Document

**Accession Number:** 0001552740
**File Stem:** 0000940400-25-010094
**Filing Date:** 2025-11
**Character Count:** 20468
**Document Hash:** c3d8e569da7a8dcffd7ca8cc325031b3
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000940400-25-010094.hdr.sgml**: 20251125

**ACCESSION NUMBER**: 0000940400-25-010094

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20250930

**FILED AS OF DATE**: 20251125

**DATE AS OF CHANGE**: 20251125

**PERIOD START**: 20260331

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** FIRST TRUST EXCHANGE-TRADED FUND VI
- **CENTRAL INDEX KEY:** 0001552740

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** MA

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-22717
- **FILM NUMBER:** 251515761

**BUSINESS ADDRESS:**
- **STREET 1:** 120 EAST LIBERTY DRIVE, SUITE 400
- **CITY:** WHEATON
- **STATE:** IL
- **ZIP:** 60187
- **BUSINESS PHONE:** 630-765-8000

**MAIL ADDRESS:**
- **STREET 1:** 120 EAST LIBERTY DRIVE, SUITE 400
- **CITY:** WHEATON
- **STATE:** IL
- **ZIP:** 60187

## Series and Classes Contracts Data

### First Trust Nasdaq Pharmaceuticals ETF (Series ID: S000053945)

| Class ID   | Class Name                             | Ticker Symbol   |
|:---|:---|:---|
| C000169747 | First Trust Nasdaq Pharmaceuticals ETF | FTXH            |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** First Trust Exchange-Traded Fund VI

- **b. Investment Company Act file number:** 811-22717

- **c. CIK number of Registrant:** 0001552740

- **d. LEI of Registrant:** 549300ZLB3EUU3H8NE60

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 120 East Liberty Drive

  - **City:** Wheaton

  - **State:** IL

  - **Foreign country:** US

  - **Zip / Postal Code:** 60187

  - **Telephone number:** 630-765-8000

**Item A.2. Information about the Series.**

- **a. Name of Series:** First Trust Nasdaq Pharmaceuticals ETF

- **b. EDGAR series identifier (if any):** S000053945

- **c. LEI of Series:** 549300YM82DADOQT2M68

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2026-03-31

- **b. Date as of which information is reported:** 2025-09-30

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $15699907.51

**Total Liabilities:** $7597.19

**Net Assets:** $15692310.32

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000169747 | 0.78%                | 7.43%                | 3.30%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $28037.08                | $47016.21                                  |
| Month 2  | $0.00                    | $1038954.30                                |
| Month 3  | $-391335.11              | $891166.81                                 |

### Schedule of Portfolio Investments

| Name                               | Title                                        | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Regeneron Pharmaceuticals Inc      | Regeneron Pharmaceuticals Inc                | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |       961 | NS      | $540341.47    | 3.44%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC Therapeutics Inc               | PTC Therapeutics Inc                         | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |      3987 | NS      | $244682.19    | 1.56%             |  |  |  | No            |                  1 | On Loan: No      |
| Rhythm Pharmaceuticals Inc         | Rhythm Pharmaceuticals Inc                   | CUSIP: 76243J105<br>LEI: 529900JPNWXQ8DPLA551 | Long             | EC               | CORP              | US        |       737 | NS      | $74429.63     | 0.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Pfizer Inc                         | Pfizer Inc                                   | CUSIP: 717081103<br>LEI: 765LHXWGK1KXCLTFYQ30 | Long             | EC               | CORP              | US        |     45086 | NS      | $1148791.28   | 7.32%             |  |  |  | No            |                  1 | On Loan: No      |
| ACADIA Pharmaceuticals Inc         | ACADIA Pharmaceuticals Inc                   | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |      2923 | NS      | $62376.82     | 0.40%             |  |  |  | No            |                  1 | On Loan: No      |
| NEWAMSTERDAM PHARMA CO NV          | NEWAMSTERDAM PHARMA CO NV-27                 | CUSIP: 000000000<br>LEI: 984500B6549TF6E14D36 | Long             | EC               | CORP              | NL        |      3159 | NS      | $89841.96     | 0.57%             |  |  |  | No            |                  1 | On Loan: No      |
| Zoetis Inc                         | Zoetis Inc                                   | CUSIP: 98978V103<br>LEI: 549300HD9Q1LOC9KLJ48 | Long             | EC               | CORP              | US        |      3569 | NS      | $522216.08    | 3.33%             |  |  |  | No            |                  1 | On Loan: No      |
| Ligand Pharmaceuticals Inc         | Ligand Pharmaceuticals Inc                   | CUSIP: 53220K504<br>LEI: 5493008K7TB0IKP37H79 | Long             | EC               | CORP              | US        |       470 | NS      | $83255.80     | 0.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Medpace Holdings Inc               | Medpace Holdings Inc                         | CUSIP: 58506Q109<br>LEI: 549300H8TYEUVTW14A54 | Long             | EC               | CORP              | US        |       372 | NS      | $191267.52    | 1.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals Inc        | Alnylam Pharmaceuticals Inc                  | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |       170 | NS      | $77520.00     | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| AbbVie Inc                         | AbbVie Inc                                   | CUSIP: 00287Y109<br>LEI: FR5LCKFTG8054YNNRU85 | Long             | EC               | CORP              | US        |      5306 | NS      | $1228551.24   | 7.83%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences Inc         | Neurocrine Biosciences Inc                   | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |       869 | NS      | $121990.22    | 0.78%             |  |  |  | No            |                  1 | On Loan: No      |
| Amgen Inc                          | Amgen Inc                                    | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |      1940 | NS      | $547468.00    | 3.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Incyte Corp                        | Incyte Corp                                  | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |      2824 | NS      | $239503.44    | 1.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Dreyfus Government Cash Management | Dreyfus Government Cash Management           | CUSIP: 262006208<br>LEI: 5493000Q69I5Q3QZIA91 | Long             | STIV             | RF                | US        |     10947 | NS      | $10947.45     | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Corcept Therapeutics Inc           | Corcept Therapeutics Inc                     | CUSIP: 218352102<br>LEI: 529900EO9LUTFMZ7FF90 | Long             | EC               | CORP              | US        |      1090 | NS      | $90589.90     | 0.58%             |  |  |  | No            |                  1 | On Loan: No      |
| Krystal Biotech Inc                | Krystal Biotech Inc                          | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |       514 | NS      | $90736.42     | 0.58%             |  |  |  | No            |                  1 | On Loan: No      |
| Johnson & Johnson                  | Johnson & Johnson                            | CUSIP: 478160104<br>LEI: 549300G0CFPGEF6X2043 | Long             | EC               | CORP              | US        |      6301 | NS      | $1168331.42   | 7.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Gilead Sciences Inc                | Gilead Sciences Inc                          | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |      4941 | NS      | $548451.00    | 3.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Elanco Animal Health Inc           | Elanco Animal Health Inc                     | CUSIP: 28414H103<br>LEI: 549300SHPNDCE059M934 | Long             | EC               | CORP              | US        |      8644 | NS      | $174090.16    | 1.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Bridgebio Pharma Inc               | Bridgebio Pharma Inc                         | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |      1468 | NS      | $76247.92     | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen Inc                         | Biogen Inc                                   | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |      4145 | NS      | $580631.60    | 3.70%             |  |  |  | No            |                  1 | On Loan: No      |
| Charles River Laboratories Int     | Charles River Laboratories International Inc | CUSIP: 159864107<br>LEI: 549300BSQ0R4UZ5KX287 | Long             | EC               | CORP              | US        |      1369 | NS      | $214193.74    | 1.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Jazz Pharmaceuticals PLC           | Jazz Pharmaceuticals PLC                     | CUSIP: 000000000<br>LEI: 635400GAUMJCLEZRRV50 | Long             | EC               | CORP              | IE        |      2625 | NS      | $345975.00    | 2.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Exelixis Inc                       | Exelixis Inc                                 | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |      5561 | NS      | $229669.30    | 1.46%             |  |  |  | No            |                  1 | On Loan: No      |
| Amneal Pharmaceuticals Inc         | Amneal Pharmaceuticals Inc                   | CUSIP: 03168L105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     10419 | NS      | $104294.19    | 0.66%             |  |  |  | No            |                  1 | On Loan: No      |
| ADMA Biologics Inc                 | ADMA Biologics Inc                           | CUSIP: 000899104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4402 | NS      | $64533.32     | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Cardinal Health Inc                | Cardinal Health Inc                          | CUSIP: 14149Y108<br>LEI: CCU46N3GJMF4OK4N7U60 | Long             | EC               | CORP              | US        |      3752 | NS      | $588913.92    | 3.75%             |  |  |  | No            |                  1 | On Loan: No      |
| Catalyst Pharmaceuticals Inc       | Catalyst Pharmaceuticals Inc                 | CUSIP: 14888U101<br>LEI: 5299004O0R5XXLA5H544 | Long             | EC               | CORP              | US        |      3795 | NS      | $74761.50     | 0.48%             |  |  |  | No            |                  1 | On Loan: No      |
| Eli Lilly & Co                     | Eli Lilly & Co                               | CUSIP: 532457108<br>LEI: FRDRIPF3EKNDJ2CQJL29 | Long             | EC               | CORP              | US        |       762 | NS      | $581406.00    | 3.71%             |  |  |  | No            |                  1 | On Loan: No      |
| Insmed Inc                         | Insmed Inc                                   | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |       558 | NS      | $80357.58     | 0.51%             |  |  |  | No            |                  1 | On Loan: No      |
| Guardant Health Inc                | Guardant Health Inc                          | CUSIP: 40131M109<br>LEI: 254900M8C3E5VC8BR186 | Long             | EC               | CORP              | US        |      1127 | NS      | $70414.96     | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Halozyme Therapeutics Inc          | Halozyme Therapeutics Inc                    | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |      2124 | NS      | $155774.16    | 0.99%             |  |  |  | No            |                  1 | On Loan: No      |
| Protagonist Therapeutics Inc       | Protagonist Therapeutics Inc                 | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1287 | NS      | $85495.41     | 0.54%             |  |  |  | No            |                  1 | On Loan: No      |
| BioMarin Pharmaceutical Inc        | BioMarin Pharmaceutical Inc                  | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |      3262 | NS      | $176669.92    | 1.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Ionis Pharmaceuticals Inc          | Ionis Pharmaceuticals Inc                    | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |      1782 | NS      | $116578.44    | 0.74%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals Inc         | Vertex Pharmaceuticals Inc                   | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |      1427 | NS      | $558870.28    | 3.56%             |  |  |  | No            |                  1 | On Loan: No      |
| Merck & Co Inc                     | Merck & Co Inc                               | CUSIP: 58933Y105<br>LEI: 4YV9Y5M8S0BRK1RP0397 | Long             | EC               | CORP              | US        |     13271 | NS      | $1113835.03   | 7.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Prestige Consumer Healthcare I     | Prestige Consumer Healthcare Inc             | CUSIP: 74112D101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1188 | NS      | $74131.20     | 0.47%             |  |  |  | No            |                  1 | On Loan: No      |
| Mirum Pharmaceuticals Inc          | Mirum Pharmaceuticals Inc                    | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |      1029 | NS      | $75435.99     | 0.48%             |  |  |  | No            |                  1 | On Loan: No      |
| Supernus Pharmaceuticals Inc       | Supernus Pharmaceuticals Inc                 | CUSIP: 868459108<br>LEI: 549300GRM36VBKISYJ58 | Long             | EC               | CORP              | US        |      1684 | NS      | $80478.36     | 0.51%             |  |  |  | No            |                  1 | On Loan: No      |
| Madrigal Pharmaceuticals Inc       | Madrigal Pharmaceuticals Inc                 | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |       174 | NS      | $79806.84     | 0.51%             |  |  |  | No            |                  1 | On Loan: No      |
| Bristol-Myers Squibb Co            | Bristol-Myers Squibb Co                      | CUSIP: 110122108<br>LEI: HLYYNH7UQUORYSJQCN42 | Long             | EC               | CORP              | US        |     23661 | NS      | $1067111.10   | 6.80%             |  |  |  | No            |                  1 | On Loan: No      |
| Tempus AI Inc                      | Tempus AI Inc                                | CUSIP: 88023B103<br>LEI: 2549009LA0KWRAGQBX50 | Long             | EC               | CORP              | US        |      1002 | NS      | $80871.42     | 0.52%             |  |  |  | No            |                  1 | On Loan: No      |
| TG Therapeutics Inc                | TG Therapeutics Inc                          | CUSIP: 88322Q108<br>LEI: 529900X21UKABN9NJ529 | Long             | EC               | CORP              | US        |      2591 | NS      | $93599.88     | 0.60%             |  |  |  | No            |                  1 | On Loan: No      |
| Alkermes PLC                       | Alkermes PLC                                 | CUSIP: 000000000<br>LEI: N/A                  | Long             | EC               | CORP              | IE        |      4715 | NS      | $141450.00    | 0.90%             |  |  |  | No            |                  1 | On Loan: No      |
| Arrowhead Pharmaceuticals Inc      | Arrowhead Pharmaceuticals Inc                | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |      3449 | NS      | $118956.01    | 0.76%             |  |  |  | No            |                  1 | On Loan: No      |
| Illumina Inc                       | Illumina Inc                                 | CUSIP: 452327109<br>LEI: SQ95QG8SR5Q56LSNF682 | Long             | EC               | CORP              | US        |      2781 | NS      | $264111.57    | 1.68%             |  |  |  | No            |                  1 | On Loan: No      |
| Viatris Inc                        | Viatris Inc                                  | CUSIP: 92556V106<br>LEI: 254900ZZTSW7NL773X71 | Long             | EC               | CORP              | US        |     52906 | NS      | $523769.40    | 3.34%             |  |  |  | No            |                  1 | On Loan: No      |
| United Therapeutics Corp           | United Therapeutics Corp                     | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |      1249 | NS      | $523593.29    | 3.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Perrigo Co PLC                     | Perrigo Co PLC                               | CUSIP: 000000000<br>LEI: 549300IFOQS6R1QLY196 | Long             | EC               | CORP              | IE        |      4148 | NS      | $92375.96     | 0.59%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2025-11-24

**Name of Applicant:** First Trust Exchange-Traded Fund VI

**Signature:** Derek Maltbie

**Name of Signer:** Derek Maltbie

**Title:** Treasurer, Chief Financial Officer and Chief Accounting Officer