# EDGAR Filing Document

**Accession Number:** 0000320351
**File Stem:** 0000035402-25-001426
**Filing Date:** 2025-10
**Character Count:** 65636
**Document Hash:** b5f792dd45af8785edfdbaad7a1cd13e
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000035402-25-001426.hdr.sgml**: 20251028

**ACCESSION NUMBER**: 0000035402-25-001426

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20250831

**FILED AS OF DATE**: 20251028

**DATE AS OF CHANGE**: 20251028

**PERIOD START**: 20260228

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** FIDELITY SELECT PORTFOLIOS
- **CENTRAL INDEX KEY:** 0000320351

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** MA
- **FISCAL YEAR END:** 0228

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-03114
- **FILM NUMBER:** 251424475

**BUSINESS ADDRESS:**
- **STREET 1:** 245 SUMMER STREET
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02210
- **BUSINESS PHONE:** 617-563-7000

**MAIL ADDRESS:**
- **STREET 1:** 245 SUMMER STREET
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02210

## Series and Classes Contracts Data

### Biotechnology Portfolio (Series ID: S000007486)

| Class ID   | Class Name              | Ticker Symbol   |
|:---|:---|:---|
| C000020460 | Biotechnology Portfolio | FBIOX           |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** Fidelity Select Portfolios

- **b. Investment Company Act file number:** 811-03114

- **c. CIK number of Registrant:** 0000320351

- **d. LEI of Registrant:** Z57125JG1LHEQKDYS630

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 245 Summer Street

  - **City:** Boston

  - **State:** MA

  - **Foreign country:** US

  - **Zip / Postal Code:** 02210

  - **Telephone number:** 1-800-FIDELITY

**Item A.2. Information about the Series.**

- **a. Name of Series:** Select Biotechnology Portfolio

- **b. EDGAR series identifier (if any):** S000007486

- **c. LEI of Series:** FQDPG178WXRZSXLIRG32

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2026-02-28

- **b. Date as of which information is reported:** 2025-08-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $4447941897.10

**Total Liabilities:** $219589131.92

**Net Assets:** $4228352765.18

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000020460 | 3.43%                | 7.62%                | 5.13%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $14150802.17             | $110965821.14                              |
| Month 2  | $6682367.29              | $274302939.43                              |
| Month 3  | $26823688.42             | $177434435.34                              |

### Schedule of Portfolio Investments

| Name                               | Title                                                               | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| CHINOOK THERAPEUTICS INC           | CHINOOK THERAPEUTICS INC CVR RT                                     | CUSIP: N/A<br>LEI: 549300X0O3003W5QYQ48       | Long             | EC               | CORP              | US        |    115821 | NS      | $1.16         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| UPSTREAM BIO INC                   | UPSTREAM BIO INC                                                    | CUSIP: 91678A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    385657 | NS      | $6606304.41   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| IDEAYA BIOSCIENCES INC             | IDEAYA BIOSCIENCES                                                  | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |    637957 | NS      | $15661844.35  | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| NEURONA THERAPEUTICS INC           | NEURONA THERAPEUTICS INC SER F PC PERP PP                           | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |   1618100 | NS      | $3333286.00   | 0.08%             |  |  |  | Yes           |                  3 | On Loan: No      |
| EXELIXIS INC                       | EXELIXIS INC                                                        | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |    471554 | NS      | $17645550.68  | 0.42%             |  |  |  | No            |                  1 | On Loan: No      |
| ABIVAX SA                          | ABIVAX SA                                                           | CUSIP: 00370M103<br>LEI: 969500D8TMNB184OJU95 | Long             | EC               | CORP              | FR        |    636000 | NS      | $51535080.00  | 1.22%             |  |  |  | No            |                  1 | On Loan: No      |
| TWIST BIOSCIENCE CORP              | TWIST BIOSCIENCE CORP                                               | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |    117325 | NS      | $3164255.25   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| DIANTHUS THERAPEUTICS INC          | DIANTHUS THERAPEUTICS INC                                           | CUSIP: 252828108<br>LEI: 549300Z3N6ODPCOFC890 | Long             | EC               | CORP              | US        |    328418 | NS      | $7740812.26   | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| BIOCRYST PHARMACEUTICALS INC       | BIOCRYST PHARMACEUTICALS INC                                        | CUSIP: 09058V103<br>LEI: 549300Z0INP1Z5NP6J59 | Long             | EC               | CORP              | US        |    313681 | NS      | $2606689.11   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| UNITED THERAPEUTICS CORP DEL       | UNITED THERAPEUTICS CORP DEL                                        | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |     13993 | NS      | $4264506.68   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| AMGEN INC                          | AMGEN INC                                                           | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |   1206501 | NS      | $347122402.71 | 8.21%             |  |  |  | No            |                  1 | On Loan: No      |
| AXSOME THERAPEUTICS INC            | AXSOME THERAPEUTICS INC                                             | CUSIP: 05464T104<br>LEI: 549300EXGR0XLRJEIB95 | Long             | EC               | CORP              | US        |    129503 | NS      | $15706123.84  | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| ABBVIE INC                         | ABBVIE INC                                                          | CUSIP: 00287Y109<br>LEI: FR5LCKFTG8054YNNRU85 | Long             | EC               | CORP              | US        |   3350739 | NS      | $704995485.60 | 16.67%            |  |  |  | No            |                  1 | On Loan: No      |
| BIOXCEL THERAPEUTICS INC           | BIOXCEL THERAPEUTICS INC                                            | CUSIP: 09075P204<br>LEI: 549300Y25FYZ0E8LW260 | Long             | EC               | CORP              | US        |    198600 | NS      | $804330.00    | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| ENTRADA THERAPEUTICS INC           | ENTRADA THERAPEUTICS INC                                            | CUSIP: 29384C108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     37469 | NS      | $204955.43    | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| MANNKIND CORP                      | MANNKIND CORP                                                       | CUSIP: 56400P706<br>LEI: 213800GFBCNY1ZFST722 | Long             | EC               | CORP              | US        |   3302701 | NS      | $15159397.59  | 0.36%             |  |  |  | No            |                  1 | On Loan: No      |
| TRIVENI BIO INC                    | TRIVENI BIO INC SERIES B PC PP                                      | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |   7167431 | NS      | $6809059.45   | 0.16%             |  |  |  | Yes           |                  3 | On Loan: No      |
| GUBRA A/S                          | GUBRA A/S                                                           | CUSIP: N/A<br>LEI: 254900T17RRFZONO6W53       | Long             | EC               | CORP              | DK        |    175554 | NS      | $10322983.50  | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| AFFERENT PHARMA                    | AFFERENT PHARMACEUTICALS INC SER C PC PP                            | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |   8274568 | NS      | $82.75        | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| LENZ THERAPEUTICS INC              | LENZ THERAPEUTICS INC                                               | CUSIP: 52635N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     71758 | NS      | $2772011.54   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| CENTESSA PHARMACEUTICALS PLC       | CENTESSA PHARMACEUTICALS LTD ADR                                    | CUSIP: 152309100<br>LEI: 213800GIDAARDSKOI827 | Long             | EC               | CORP              | GB        |   2614494 | NS      | $43897354.26  | 1.04%             |  |  |  | No            |                  1 | On Loan: —       |
| FOGHORN THERAPEUTICS INC           | FOGHORN THERAPEUTICS INC                                            | CUSIP: 344174107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     66020 | NS      | $334061.20    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| MEREO BIOPHARMA GROUP PLC          | MEREO BIOPHARMA ADR                                                 | CUSIP: 589492107<br>LEI: 213800U8JQHIJOS5AS09 | Long             | EC               | CORP              | GB        |    838700 | NS      | $1434177.00   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| TREVI THERAPEUTICS INC             | TREVI THERAPEUTICS INC                                              | CUSIP: 89532M101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2593763 | NS      | $18817750.57  | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| TG THERAPEUTICS INC                | TG THERAPEUTICS INC                                                 | CUSIP: 88322Q108<br>LEI: 529900X21UKABN9NJ529 | Long             | EC               | CORP              | US        |    714578 | NS      | $20958572.74  | 0.50%             |  |  |  | No            |                  1 | On Loan: —       |
| CRINETICS PHARMACEUTICALS INC      | CRINETICS PHARMACEUTICALS INC                                       | CUSIP: 22663K107<br>LEI: 549300Q1CNFXK5P31D28 | Long             | EC               | CORP              | US        |    919404 | NS      | $28492329.96  | 0.67%             |  |  |  | No            |                  1 | On Loan: No      |
| ABSCI CORP                         | ABSCI CORP                                                          | CUSIP: 00091E109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1785096 | NS      | $4266379.44   | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| ASTRIA THERAPEUTICS INC            | ASTRIA THERAPEUTICS INC                                             | CUSIP: 04635X102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    469456 | NS      | $2901238.08   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| BICARA THERAPEUTICS INC            | BICARA THERAPEUTICS INC                                             | CUSIP: 055477103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    348000 | NS      | $4155120.00   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| GERON CORP                         | GERON CORP WT 07/02/2024                                            | CUSIP: 374163129<br>LEI: 549300T282D7Z2YESL90 | Long             | EC               | CORP              | US        |   2080400 | NS      | $229945.18    | 0.01%             |  |  |  | No            |                  2 | On Loan: No      |
| BIO AB HOLDINGS LLC                | BIO AB2 HOLDINGS LLC ADI                                            | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |   1954526 | NS      | $9205817.46   | 0.22%             |  |  |  | Yes           |                  3 | On Loan: No      |
| IMMUNOCORE HOLDINGS PLC            | IMMUNOCORE HOLDINGS LTD ADR                                         | CUSIP: 45258D105<br>LEI: 213800IUE3DFS84BVN18 | Long             | EC               | CORP              | GB        |    162505 | NS      | $5235911.10   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| BIOMEA FUSION INC                  | BIOMEA FUSION INC WT 12/20/2026                                     | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |     29200 | NS      | $8737.01      | 0.00%             |  |  |  | No            |                  2 | On Loan: No      |
| KORRO BIO INC                      | KORRO BIO INC PIPE                                                  | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |     32866 | NS      | $758547.28    | 0.02%             |  |  |  | Yes           |                  1 | On Loan: No      |
| INTELLIA THERAPEUTICS INC          | INTELLIA THERAPEUTICS INC                                           | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |   1017121 | NS      | $11549408.96  | 0.27%             |  |  |  | No            |                  1 | On Loan: —       |
| REGENERON PHARMACEUTICALS INC      | REGENERON PHARMACEUTICALS INC                                       | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |     77396 | NS      | $44943857.20  | 1.06%             |  |  |  | No            |                  1 | On Loan: No      |
| NEWAMSTERDAM PHARMA COMPANY NV     | NEWAMSTERDAM PHARMA COMPANY NV                                      | CUSIP: N/A<br>LEI: 984500B6549TF6E14D36       | Long             | EC               | CORP              | NL        |    687500 | NS      | $16534375.00  | 0.39%             |  |  |  | No            |                  1 | On Loan: —       |
| SALIOGEN THERAPEUTICS INC          | SALIOGEN THERAPEUTICS INC SER B PC PP                               | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |     94461 | NS      | $0.94         | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| CRESCENT BIOPHARMA INC             | CRESCENT BIOPHARMA INC PIPE                                         | CUSIP: N/A<br>LEI: 549300TZ84FFU2J2J459       | Long             | EC               | CORP              | KY        |    113421 | NS      | $1633262.40   | 0.04%             |  |  |  | Yes           |                  1 | On Loan: No      |
| DISC MEDICINE INC                  | DISC MEDICINE INC                                                   | CUSIP: 254604101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    783188 | NS      | $46713248.26  | 1.10%             |  |  |  | No            |                  1 | On Loan: —       |
| PROTHENA CORP PLC                  | PROTHENA CORP PLC                                                   | CUSIP: N/A<br>LEI: 5299009ZXQ8NIIJ8OL30       | Long             | EC               | CORP              | IE        |    643917 | NS      | $5280119.40   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| AMYLYX PHARMACEUTICALS INC         | AMYLYX PHARMACEUTICALS INC                                          | CUSIP: 03237H101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1203275 | NS      | $11286719.50  | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| ARROWHEAD PHARMACEUTICALS INC      | ARROWHEAD PHARMACEUTICALS INC                                       | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |    208215 | NS      | $4586976.45   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| KRYSTAL BIOTECH INC                | KRYSTAL BIOTECH INC                                                 | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |   1855422 | NS      | $274045829.40 | 6.48%             |  |  |  | No            |                  1 | On Loan: —       |
| GH RESEARCH PLC                    | GH RESEARCH PLC                                                     | CUSIP: N/A<br>LEI: 875500HKJS7QQG6EWH62       | Long             | EC               | CORP              | IE        |    305700 | NS      | $4126950.00   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| CARDURION PHARMACEUTICALS INC      | CARDURION PHARMACEUTICALS INC SER B PC PP                           | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |   1020908 | NS      | $4583876.92   | 0.11%             |  |  |  | Yes           |                  3 | On Loan: No      |
| MOONLAKE IMMUNOTHERAPEUTICS        | MOONLAKE IMMUNOTHERAPEUTICS                                         | CUSIP: 61559X104<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |    518858 | NS      | $28926333.50  | 0.68%             |  |  |  | No            |                  1 | On Loan: —       |
| ARADIGM CORP                       | ARADIGM CORP PIPE                                                   | CUSIP: N/A<br>LEI: 549300I46MRQ1CGCIY65       | Long             | EC               | CORP              | US        |    148009 | NS      | $1.48         | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ORUKA THERAPEUTICS INC             | ORUKA THERAPEUTICS INC                                              | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |    704983 | NS      | $10433748.40  | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| SCHOLAR ROCK HOLDING CORP          | SCHOLAR ROCK HOLDING CORP                                           | CUSIP: 80706P103<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |   1632599 | NS      | $53304357.35  | 1.26%             |  |  |  | No            |                  1 | On Loan: No      |
| SANA BIOTECHNOLOGY INC             | SANA BIOTECHNOLOGY INC                                              | CUSIP: 799566104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1263152 | NS      | $3865245.12   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| NURIX THERAPEUTICS INC             | NURIX THERAPEUTICS INC                                              | CUSIP: 67080M103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    450446 | NS      | $4207165.64   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| ARS PHARMACEUTICALS INC            | ARS PHARMACEUTICALS INC                                             | CUSIP: 82835W108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    888656 | NS      | $10326182.72  | 0.24%             |  |  |  | No            |                  1 | On Loan: —       |
| MBX BIOSCIENCES INC                | MBX BIOSCIENCES INC                                                 | CUSIP: 55287L101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    452300 | NS      | $6825207.00   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| KEROS THERAPEUTICS INC             | KEROS THERAPEUTICS                                                  | CUSIP: 492327101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    116178 | NS      | $1767067.38   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| GRITSTONE BIO INC                  | GRITSTONE BIO INC WT                                                | CUSIP: N/A<br>LEI: 5493003TER6KY3MUVY84       | Long             | EC               | CORP              | US        |   1333333 | NS      | $13.33        | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| APELLIS PHARMACEUTICALS INC        | APELLIS PHARMACEUTICALS INC                                         | CUSIP: 03753U106<br>LEI: 254900HS0ZFRXXSB9D42 | Long             | EC               | CORP              | US        |     11222 | NS      | $309390.54    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| BIO AB HOLDINGS LLC                | BIO AB2 HOLDINGS LLC ARC                                            | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |   1954526 | NS      | $29181073.18  | 0.69%             |  |  |  | Yes           |                  3 | On Loan: No      |
| SOLID BIOSCIENCES INC              | SOLID BIOSCIENCES INC                                               | CUSIP: 83422E204<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2867760 | NS      | $15715324.80  | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| ARGENX SE                          | ARGENX SE SPONSORED ADR                                             | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |    165004 | NS      | $117515848.80 | 2.78%             |  |  |  | No            |                  1 | On Loan: No      |
| CAMP4 THERAPEUTICS CORP            | CAMP4 THERAPEUTICS CORP                                             | CUSIP: 13463J101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    241086 | NS      | $366450.72    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| REPLIMUNE GROUP INC                | REPLIMUNE GROUP INC                                                 | CUSIP: 76029N106<br>LEI: 549300AY704NEIRC4K64 | Long             | EC               | CORP              | US        |   1000709 | NS      | $5403828.60   | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| CYCLERION THERAPEUTICS INC         | CYCLERION THERAPEUTICS INC PP PIPE                                  | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |      4740 | NS      | $11613.00     | 0.00%             |  |  |  | Yes           |                  1 | On Loan: No      |
| EDGEWISE THERAPEUTICS INC          | EDGEWISE THERAPEUTICS INC                                           | CUSIP: 28036F105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    200021 | NS      | $2870301.35   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| DESIGN THERAPEUTICS INC            | DESIGN THERAPEUTICS INC                                             | CUSIP: 25056L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    743531 | NS      | $4111726.43   | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| ULTRAGENYX PHARMACEUTICAL INC      | ULTRAGENYX PHARMA INC                                               | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |    727789 | NS      | $21804558.44  | 0.52%             |  |  |  | No            |                  1 | On Loan: No      |
| SENSORION SA                       | SENSORION SA                                                        | CUSIP: N/A<br>LEI: 969500P0W8XJ9CGZDP97       | Long             | EC               | CORP              | FR        |  18827089 | NS      | $7070285.49   | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| CARTESIAN THERAPEUTICS INC         | CARTESIAN THERAPEUTICS INC                                          | CUSIP: 816212302<br>LEI: 529900NMN0LACZOL7C43 | Long             | EC               | CORP              | US        |    599054 | NS      | $6020492.70   | 0.14%             |  |  |  | No            |                  1 | On Loan: —       |
| VTV THERAPEUTICS INC               | VTV THERAPEUTICS INC CL A                                           | CUSIP: 918385204<br>LEI: 549300WQE5EI9R35SE66 | Long             | EC               | CORP              | US        |    177299 | NS      | $2684306.86   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| TECTONIC THERAPEUTIC INC           | TECTONIC THERAPEUTIC INC                                            | CUSIP: 878972108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    442889 | NS      | $11311385.06  | 0.27%             |  |  |  | No            |                  1 | On Loan: —       |
| MEDAVAIL HOLDINGS INC              | MEDAVAIL HOLDINGS INC PIPE                                          | CUSIP: N/A<br>LEI: 549300ZNQGSJ2V3ZB668       | Long             | EC               | CORP              | US        |        55 | NS      | $0.01         | 0.00%             |  |  |  | Yes           |                  1 | On Loan: No      |
| PERSPECTIVE THERAPEUTICS INC       | PERSPECTIVE THERAPEUTICS INC                                        | CUSIP: 46489V302<br>LEI: 5493005LRKM6BCABC605 | Long             | EC               | CORP              | US        |    632400 | NS      | $2124864.00   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| SCORPION THERAPEUTICS INC          | SCORPION THERAPEUTICS INC INDEMNITY ESCROW LINE PP                  | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |   5166448 | NS      | $1704927.84   | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| IMMUNOME INC                       | IMMUNOME INC                                                        | CUSIP: 45257U108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    769185 | NS      | $7314949.35   | 0.17%             |  |  |  | No            |                  1 | On Loan: —       |
| ARADIGM CORP                       | ARADIGM CORP                                                        | CUSIP: N/A<br>LEI: 549300I46MRQ1CGCIY65       | Long             | EC               | CORP              | US        |     11945 | NS      | $0.12         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| NOVOCURE LTD                       | NOVOCURE LTD                                                        | CUSIP: N/A<br>LEI: 213800YPP55UMHWA4826       | Long             | EC               | CORP              | JE        |     11113 | NS      | $137023.29    | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| UNIQURE N.V.                       | UNIQURE N.V.                                                        | CUSIP: N/A<br>LEI: 724500RPCTZLFYJZ3S98       | Long             | EC               | CORP              | NL        |    373382 | NS      | $6097328.06   | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| AVIDITY BIOSCIENCES INC            | AVIDITY BIOSCIENCES                                                 | CUSIP: 05370A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    727307 | NS      | $33877960.06  | 0.80%             |  |  |  | No            |                  1 | On Loan: No      |
| BIONTECH SE                        | BIONTECH SE ADR                                                     | CUSIP: 09075V102<br>LEI: 894500UZJ5LG1F8J1U58 | Long             | EC               | CORP              | DE        |    148500 | NS      | $14850000.00  | 0.35%             |  |  |  | No            |                  1 | On Loan: —       |
| JANUX THERAPEUTICS INC             | JANUX THERAPEUTICS INC                                              | CUSIP: 47103J105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    342799 | NS      | $7788393.28   | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| ALLOGENE THERAPEUTICS INC          | ALLOGENE THERAPEUTICS INC                                           | CUSIP: 019770106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    841115 | NS      | $950459.95    | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| ENLIVEN THERAPEUTICS INC           | ENLIVEN THERAPEUTICS INC                                            | CUSIP: 29337E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    377767 | NS      | $7657337.09   | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| ANTARES THERAPEUTICS INC           | ANTARES THERAPEUTICS INC                                            | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |    325500 | NS      | $270165.00    | 0.01%             |  |  |  | No            |                  3 | On Loan: No      |
| CARTESIAN THERAPEUTICS INC         | CARTESIAN THERAPEUTICS INC CVR RT                                   | CUSIP: 816212112<br>LEI: 529900NMN0LACZOL7C43 | Long             | EC               | CORP              | US        |   5385728 | NS      | $1561861.12   | 0.04%             |  |  |  | No            |                  3 | On Loan: No      |
| REVOLUTION MEDICINES INC           | REVOLUTION MEDICINES INC                                            | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |    175398 | NS      | $6659862.06   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| BRIDGEBIO PHARMA INC               | BRIDGEBIO PHARMA INC                                                | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |    632804 | NS      | $32753935.04  | 0.77%             |  |  |  | No            |                  1 | On Loan: No      |
| GOSSAMER BIO INC                   | GOSSAMER BIO INC                                                    | CUSIP: 38341P102<br>LEI: 549300ZOC0N2W6PSFR58 | Long             | EC               | CORP              | US        |   4899808 | NS      | $12102525.76  | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| NUVATION BIO INC                   | NUVATION BIO INC                                                    | CUSIP: 67080N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   5827833 | NS      | $17308664.01  | 0.41%             |  |  |  | No            |                  1 | On Loan: —       |
| SCHRODINGER INC                    | SCHRODINGER INC                                                     | CUSIP: 80810D103<br>LEI: 984500044BAE4791E559 | Long             | EC               | CORP              | US        |    235401 | NS      | $4592673.51   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| VAXCYTE INC                        | VAXCYTE INC                                                         | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |    599955 | NS      | $18472614.45  | 0.44%             |  |  |  | No            |                  1 | On Loan: No      |
| MODERNA INC                        | MODERNA INC                                                         | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |    674122 | NS      | $16239598.98  | 0.38%             |  |  |  | No            |                  1 | On Loan: No      |
| VIRIDIAN THERAPEUTICS INC          | VIRIDIAN THERAPEUTICS INC                                           | CUSIP: 92790C104<br>LEI: 549300C775BNYF550E70 | Long             | EC               | CORP              | US        |    917404 | NS      | $16861885.52  | 0.40%             |  |  |  | No            |                  1 | On Loan: No      |
| SOLENO THERAPEUTICS INC            | SOLENO THERAPEUTICS INC                                             | CUSIP: 834203309<br>LEI: 5493003LCY77N7FXK844 | Long             | EC               | CORP              | US        |    169100 | NS      | $11442997.00  | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| SPYRE THERAPEUTICS INC             | SPYRE THERAPEUTICS INC                                              | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |    284853 | NS      | $4697225.97   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| REZOLUTE INC                       | REZOLUTE INC                                                        | CUSIP: 76200L309<br>LEI: 549300T05L48T72P2G08 | Long             | EC               | CORP              | US        |    720167 | NS      | $5127589.04   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| CANDEL THERAPEUTICS INC            | CANDEL THERAPEUTICS INC                                             | CUSIP: 137404109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   5544979 | NS      | $32105428.41  | 0.76%             |  |  |  | No            |                  1 | On Loan: —       |
| VERA THERAPEUTICS INC              | VERA THERAPEUTICS INC                                               | CUSIP: 92337R101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    350625 | NS      | $7587525.00   | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| IDORSIA LTD                        | IDORSIA LTD                                                         | CUSIP: N/A<br>LEI: 506700XOVZUB107S5720       | Long             | EC               | CORP              | CH        |    256353 | NS      | $884252.05    | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| STRUCTURE THERAPEUTICS INC         | STRUCTURE THERAPEUTICS INC ADR                                      | CUSIP: 86366E106<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |    383764 | NS      | $7406645.20   | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| INHIBIKASE THERAPEUTICS INC        | INHIBIKASE THERAPEUTICS INC                                         | CUSIP: 45719W205<br>LEI: 549300066CFEWOA17F12 | Long             | EC               | CORP              | US        |    127670 | NS      | $229806.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| SUMMIT THERAPEUTICS INC            | SUMMIT THERAPEUTICS INC                                             | CUSIP: 86627T108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1468678 | NS      | $34807668.60  | 0.82%             |  |  |  | No            |                  1 | On Loan: —       |
| ANNEXON INC                        | ANNEXON INC                                                         | CUSIP: 03589W102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    300887 | NS      | $619827.22    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| SCORPION THERAPEUTICS INC          | SCORPION THERAPEUTICS INC SHAREHOLDER REPRESENTATIVE ESCROW LINE PP | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |   5166448 | NS      | $51.66        | 0.00%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ROIVANT SCIENCES LTD               | ROIVANT SCIENCES LTD                                                | CUSIP: N/A<br>LEI: 549300DL466NY5J6U724       | Long             | EC               | CORP              | BM        |    953219 | NS      | $11371902.67  | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| JADE BIOSCIENCES INC               | JADE BIOSCIENCES INC                                                | CUSIP: 008064206<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    218307 | NS      | $1724625.30   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| PROTAGONIST THERAPEUTICS INC       | PROTAGONIST THERAPEUTICS INC                                        | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    429113 | NS      | $25339122.65  | 0.60%             |  |  |  | No            |                  1 | On Loan: —       |
| CYTOKINETICS INC                   | CYTOKINETICS INC                                                    | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |    540575 | NS      | $19098514.75  | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| ATYR PHARMA INC                    | ATYR PHARMA INC                                                     | CUSIP: 002120202<br>LEI: 529900ENQUXMC5EBKO36 | Long             | EC               | CORP              | US        |   1754594 | NS      | $9439715.72   | 0.22%             |  |  |  | No            |                  1 | On Loan: —       |
| NATIONAL RESILIENCE INC            | NATIONAL RESILIENCE INC SER B PC PP                                 | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |    732064 | NS      | $5168371.84   | 0.12%             |  |  |  | Yes           |                  3 | On Loan: No      |
| SCHOLAR ROCK HOLDING CORP          | SCHOLAR ROCK HOLDING CORP WT 12/31/2025 PP                          | CUSIP: N/A<br>LEI: 549300Z1FLPGL4OWJ459       | Long             | EC               | CORP              | US        |     17850 | NS      | $453468.13    | 0.01%             |  |  |  | Yes           |                  2 | On Loan: No      |
| ALECTOR INC                        | ALECTOR INC                                                         | CUSIP: 014442107<br>LEI: 549300Z8RQOIY1JMHC25 | Long             | EC               | CORP              | US        |   3590551 | NS      | $8437794.85   | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| GALDERMA GROUP AG                  | GALDERMA GROUP AG                                                   | CUSIP: N/A<br>LEI: 89450001OK6O8ELQ4584       | Long             | EC               | CORP              | CH        |    205570 | NS      | $35865240.27  | 0.85%             |  |  |  | No            |                  1 | On Loan: No      |
| Fidelity Revere Street Trust       | Fidelity Cash Central Fund                                          | CUSIP: 31635A105<br>LEI: 549300BDV45LJNXBZC55 | Long             | STIV             | RF                | US        |   7476721 | NS      | $7478216.52   | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| AKERO THERAPEUTICS INC             | AKERO THERAPEUTICS INC                                              | CUSIP: 00973Y108<br>LEI: 549300SI3KG74LBE2955 | Long             | EC               | CORP              | US        |     30400 | NS      | $1420592.00   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| WAVE LIFE SCIENCES LTD             | WAVE LIFE SCIENCES LTD                                              | CUSIP: N/A<br>LEI: 54930070006GPKFYZ813       | Long             | EC               | CORP              | SG        |    522340 | NS      | $5014464.00   | 0.12%             |  |  |  | No            |                  1 | On Loan: —       |
| ASCENDIS PHARMA A/S                | ASCENDIS PHARMA AS SPON ADR                                         | CUSIP: 04351P101<br>LEI: 549300B66JN3W3J8GH73 | Long             | EC               | CORP              | DK        |    582501 | NS      | $113162469.27 | 2.68%             |  |  |  | No            |                  1 | On Loan: No      |
| LEGEND BIOTECH CORP                | LEGEND BIOTECH CORP SPON ADR                                        | CUSIP: 52490G102<br>LEI: 254900EIUFZTW136H859 | Long             | EC               | CORP              | KY        |     91610 | NS      | $3181615.30   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| GERON CORP                         | GERON CORP                                                          | CUSIP: 374163103<br>LEI: 549300T282D7Z2YESL90 | Long             | EC               | CORP              | US        |   9077512 | NS      | $12708516.80  | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| METSERA INC                        | METSERA INC                                                         | CUSIP: 59267L107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    761547 | NS      | $26874993.63  | 0.64%             |  |  |  | No            |                  1 | On Loan: No      |
| 89BIO INC                          | 89BIO INC                                                           | CUSIP: 282559103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    271300 | NS      | $2449839.00   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| VERTEX PHARMACEUTICALS INC         | VERTEX PHARMACEUTICALS INC                                          | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |     26109 | NS      | $10209141.18  | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| ASTRIA THERAPEUTICS INC            | ASTRIA THERAPEUTICS INC WT                                          | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |    115136 | NS      | $206994.98    | 0.00%             |  |  |  | No            |                  2 | On Loan: No      |
| BIOHAVEN LTD                       | BIOHAVEN LTD                                                        | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | VG        |   1757096 | NS      | $27041707.44  | 0.64%             |  |  |  | No            |                  1 | On Loan: No      |
| AXCELLA HEALTH INC                 | AXCELLA HEALTH INC                                                  | CUSIP: 05454B204<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     66454 | NS      | $0.66         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| NATERA INC                         | NATERA INC                                                          | CUSIP: 632307104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    331532 | NS      | $55780259.00  | 1.32%             |  |  |  | No            |                  1 | On Loan: No      |
| OPTINOSE INC                       | OPTINOSE INC WT 11/23/27                                            | CUSIP: 68404V118<br>LEI: 549300CPBME7Z3CYMN16 | Long             | EC               | CORP              | US        |     91712 | NS      | $0.92         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| VIR BIOTECHNOLOGY INC              | VIR BIOTECHNOLOGY INC                                               | CUSIP: 92764N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    149800 | NS      | $740012.00    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| PHARVARIS BV                       | PHARVARIS BV                                                        | CUSIP: N/A<br>LEI: 9845003BE146D3B75D32       | Long             | EC               | CORP              | NL        |    147914 | NS      | $3202338.10   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| CANDID THERAPEUTICS                | CANDID THERAPEUTICS INC SER B PC PP                                 | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |   1666667 | NS      | $1650000.33   | 0.04%             |  |  |  | Yes           |                  3 | On Loan: No      |
| MADRIGAL PHARMACEUTICALS INC       | MADRIGAL PHARMACEUTICALS INC                                        | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |     50895 | NS      | $22284375.75  | 0.53%             |  |  |  | No            |                  1 | On Loan: —       |
| EXACT SCIENCES CORP                | EXACT SCIENCES CORP                                                 | CUSIP: 30063P105<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |     56800 | NS      | $2693456.00   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC THERAPEUTICS INC               | PTC THERAPEUTICS INC                                                | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |    274511 | NS      | $13541627.63  | 0.32%             |  |  |  | No            |                  1 | On Loan: No      |
| IMMUNEERING CORP                   | IMMUNEERING CORP                                                    | CUSIP: 45254E107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    377776 | NS      | $2172212.00   | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| ARCELLX INC                        | ARCELLX INC                                                         | CUSIP: 03940C100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    496600 | NS      | $34459074.00  | 0.81%             |  |  |  | No            |                  1 | On Loan: —       |
| STOKE THERAPEUTICS INC             | STOKE THERAPEUTICS INC                                              | CUSIP: 86150R107<br>LEI: 549300RD25SS2DIJHJ67 | Long             | EC               | CORP              | US        |   1565839 | NS      | $30940978.64  | 0.73%             |  |  |  | No            |                  1 | On Loan: —       |
| DAY ONE BIOPHARMACEUTICALS INC     | DAY ONE BIOPHARMACEUTICALS INC                                      | CUSIP: 23954D109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    767066 | NS      | $5760665.66   | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| UCB SA                             | UCB SA                                                              | CUSIP: N/A<br>LEI: 2138008J191VLSGY5A09       | Long             | EC               | CORP              | BE        |    377874 | NS      | $88348647.54  | 2.09%             |  |  |  | No            |                  1 | On Loan: No      |
| BEONE MEDICINES LTD                | BEONE MEDICINES LTD ADR                                             | CUSIP: 07725L102<br>LEI: 549300JFUK6FRD5MH739 | Long             | EC               | CORP              | CH        |      8198 | NS      | $2508997.90   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| RHYTHM PHARMACEUTICALS INC         | RHYTHM PHARMACEUTICALS INC                                          | CUSIP: 76243J105<br>LEI: 529900JPNWXQ8DPLA551 | Long             | EC               | CORP              | US        |    157003 | NS      | $16194859.45  | 0.38%             |  |  |  | No            |                  1 | On Loan: No      |
| DYNE THERAPEUTICS INC              | DYNE THERAPEUTICS INC                                               | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1689544 | NS      | $22791948.56  | 0.54%             |  |  |  | No            |                  1 | On Loan: No      |
| ARRIVENT BIOPHARMA INC             | ARRIVENT BIOPHARMA INC                                              | CUSIP: 04272N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   2346517 | NS      | $44865405.04  | 1.06%             |  |  |  | No            |                  1 | On Loan: —       |
| RAPPORT THERAPEUTICS INC           | RAPPORT THERAPEUTICS INC                                            | CUSIP: 75383L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    171063 | NS      | $3015840.69   | 0.07%             |  |  |  | No            |                  1 | On Loan: —       |
| ALNYLAM PHARMACEUTICALS INC        | ALNYLAM PHARMACEUTICALS INC                                         | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |    655003 | NS      | $292465389.53 | 6.92%             |  |  |  | No            |                  1 | On Loan: No      |
| ZENAS BIOPHARMA INC                | ZENAS BIOPHARMA INC                                                 | CUSIP: 98937L105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    164900 | NS      | $2638400.00   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| HARMONY BIOSCIENCES HOLDINGS INC   | HARMONY BIOSCIENCES HOLDINGS INC                                    | CUSIP: 413197104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     46725 | NS      | $1723685.25   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| ZEALAND PHARMA A/S                 | ZEALAND PHARMA A/S                                                  | CUSIP: N/A<br>LEI: 549300ITBB1ULBL4CZ12       | Long             | EC               | CORP              | DK        |    653130 | NS      | $44772370.12  | 1.06%             |  |  |  | No            |                  1 | On Loan: No      |
| LEXICON PHARMACEUTICALS INC        | LEXICON PHARMACEUTICALS INC                                         | CUSIP: 528872302<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1366400 | NS      | $1503040.00   | 0.04%             |  |  |  | No            |                  1 | On Loan: —       |
| CORCEPT THERAPEUTICS INC           | CORCEPT THERAPEUTICS INC                                            | CUSIP: 218352102<br>LEI: 529900EO9LUTFMZ7FF90 | Long             | EC               | CORP              | US        |    648746 | NS      | $45230571.12  | 1.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Fidelity Revere Street Trust       | Fidelity Securities Lending Cash Central Fund                       | CUSIP: 31635A303<br>LEI: 549300BDV45LJNXBZC55 | Long             | STIV             | RF                | US        | 211241812 | NS      | $211262936.17 | 5.00%             |  |  |  | No            |                  1 | On Loan: No      |
| IMMUNOVANT INC                     | IMMUNOVANT INC                                                      | CUSIP: 45258J102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    629621 | NS      | $9249132.49   | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| KYMERA THERAPEUTICS INC            | KYMERA THERAPEUTICS INC                                             | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    276641 | NS      | $11397609.20  | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| BEAM THERAPEUTICS INC              | BEAM THERAPEUTICS INC                                               | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    251214 | NS      | $4109861.04   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| XENON PHARMACEUTICALS INC          | XENON PHARMACEUTICALS INC                                           | CUSIP: 98420N105<br>LEI: 549300XV44Q9Z1MIPQ03 | Long             | EC               | CORP              | CA        |    411764 | NS      | $15939384.44  | 0.38%             |  |  |  | No            |                  1 | On Loan: No      |
| TRAVERE THERAPEUTICS INC           | TRAVERE THERAPEUTICS INC                                            | CUSIP: 89422G107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    594900 | NS      | $10410750.00  | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| ANAPTYSBIO INC                     | ANAPTYSBIO INC                                                      | CUSIP: 032724106<br>LEI: 529900HH4WQT03IG1A12 | Long             | EC               | CORP              | US        |     61900 | NS      | $1258427.00   | 0.03%             |  |  |  | No            |                  1 | On Loan: —       |
| COGENT BIOSCIENCES INC             | COGENT BIOSCIENCES INC                                              | CUSIP: 19240Q201<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1566594 | NS      | $18924455.52  | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| CG ONCOLOGY INC                    | CG ONCOLOGY INC                                                     | CUSIP: 156944100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    382439 | NS      | $10257013.98  | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| DENALI THERAPEUTICS INC            | DENALI THERAPEUTICS INC                                             | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |    442063 | NS      | $6750302.01   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| OCULAR THERAPEUTIX INC             | OCULAR THERAPEUTIX INC                                              | CUSIP: 67576A100<br>LEI: 529900ABAWFXOHSIHG03 | Long             | EC               | CORP              | US        |    679900 | NS      | $8301579.00   | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| INSMED INC                         | INSMED INC                                                          | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |   1007619 | NS      | $137136945.90 | 3.24%             |  |  |  | No            |                  1 | On Loan: No      |
| MAZE THERAPEUTICS INC              | MAZE THERAPEUTICS INC                                               | CUSIP: 578784100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    273585 | NS      | $3964246.65   | 0.09%             |  |  |  | No            |                  1 | On Loan: —       |
| GILEAD SCIENCES INC                | GILEAD SCIENCES INC                                                 | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |   3013711 | NS      | $340458931.67 | 8.05%             |  |  |  | No            |                  1 | On Loan: No      |
| TAYSHA GENE THERAPIES INC          | TAYSHA GENE THERAPIES INC                                           | CUSIP: 877619106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   3111976 | NS      | $9086969.92   | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| ALLENA PHARMACEUTICALS INC         | ALLENA PHARMACEUTICALS INC                                          | CUSIP: 018119107<br>LEI: 549300749HO5QS40BX97 | Long             | EC               | CORP              | US        |     93683 | NS      | $0.94         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| VIKING THERAPEUTICS INC            | VIKING THERAPEUTICS INC                                             | CUSIP: 92686J106<br>LEI: 529900IVC72YPFA25M37 | Long             | EC               | CORP              | US        |    421957 | NS      | $11413936.85  | 0.27%             |  |  |  | No            |                  1 | On Loan: —       |
| APOGEE THERAPEUTICS INC            | APOGEE THERAPEUTICS INC                                             | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    392132 | NS      | $14261840.84  | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| ZURA BIO LTD                       | ZURA BIO LTD A                                                      | CUSIP: N/A<br>LEI: 549300LQXD6M2MIQFN24       | Long             | EC               | CORP              | KY        |    484957 | NS      | $989312.28    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| BIOMEA FUSION INC                  | BIOMEA FUSION INC                                                   | CUSIP: 09077A106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    420729 | NS      | $820421.55    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| MERUS NV                           | MERUS B.V.                                                          | CUSIP: N/A<br>LEI: 549300W8GPUWU8QNU293       | Long             | EC               | CORP              | NL        |    703554 | NS      | $46321995.36  | 1.10%             |  |  |  | No            |                  1 | On Loan: No      |
| CIDARA THERAPEUTICS INC            | CIDARA THERAPEUTICS INC                                             | CUSIP: 171757206<br>LEI: 549300IHQ9Z7RI1X2D22 | Long             | EC               | CORP              | US        |     51518 | NS      | $3368762.02   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| SCORPION THERAPEUTICS INC          | SCORPION THERAPEUTICS INC CVR 03/05/2040 PP                         | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |   5166448 | NS      | $2893210.88   | 0.07%             |  |  |  | Yes           |                  3 | On Loan: No      |
| ELEVATEBIO, LLC                    | ELEVATEBIO LLC SER C PC PP                                          | CUSIP: N/A<br>LEI: N/A                        | Long             | EP               | CORP              | US        |    216600 | NS      | $452694.00    | 0.01%             |  |  |  | Yes           |                  3 | On Loan: No      |
| IONIS PHARMACEUTICALS INC          | IONIS PHARMACEUTICALS INC                                           | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |    500777 | NS      | $21350627.40  | 0.50%             |  |  |  | No            |                  1 | On Loan: No      |
| NUVALENT INC                       | NUVALENT INC-A                                                      | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    268899 | NS      | $20592285.42  | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| ARCUS BIOSCIENCES INC              | ARCUS BIOSCIENCES INC                                               | CUSIP: 03969F109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1068989 | NS      | $11320593.51  | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| ARCTURUS THERAPEUTICS HOLDINGS INC | ARCTURUS THERAPEUTICS HOLDINGS INC                                  | CUSIP: 03969T109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    159230 | NS      | $2708502.30   | 0.06%             |  |  |  | No            |                  1 | On Loan: —       |
| FORTE BIOSCIENCES INC              | FORTE BIOSCIENCES INC                                               | CUSIP: 34962G208<br>LEI: 529900Z84WFDHPS3JP76 | Long             | EC               | CORP              | US        |     69390 | NS      | $763290.00    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2025-09-30

**Name of Applicant:** Stacie M. Smith

**Signature:** Stacie M. Smith

**Name of Signer:** Stacie M. Smith

**Title:** President and Treasurer