# EDGAR Filing Document

**Accession Number:** 0001888886
**File Stem:** 0001104659-23-008579
**Filing Date:** 2023-1
**Character Count:** 4444
**Document Hash:** 12a155a40b7f481f9aa66762318bcc54
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-23-008579.hdr.sgml**: 20230306

**ACCESSION NUMBER**: 0001104659-23-008579

**CONFORMED SUBMISSION TYPE**: CORRESP

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20230131

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Structure Therapeutics Inc.
- **CENTRAL INDEX KEY:** 0001888886
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 981480821
- **STATE OF INCORPORATION:** E9
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** CORRESP

**BUSINESS ADDRESS:**
- **STREET 1:** 611 GATEWAY BLVD SUITE 223
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080
- **BUSINESS PHONE:** (628) 229-9277

**MAIL ADDRESS:**
- **STREET 1:** 611 GATEWAY BLVD SUITE 223
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ShouTi Inc.
- **DATE OF NAME CHANGE:** 20211019

January 31, 2023

Jefferies LLC

520 Madison Avenue

New York, New York 10022

SVB Securities LLC

53 State Street, 40th Floor

Boston, MA 02109

Guggenheim Securities, LLC

330 Madison Avenue

New York, New York 10017

BMO Capital Markets Corp.

151 W. 42nd Street, 31st Floor

New York, New York 10036

**<u>VIA EDGAR</u>**

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attn: Vanessa Robertson

Terence O'Brien

Jimmy McNamara

Joe McCann

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| | |
|:---|:---|
| **Re:** | **Structure Therapeutics Inc.<br> Registration Statement on Form S-1** |

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**(File No. 333-269200)**

**Acceleration Request**

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| | |
|:---|:---|
| **Requested Date:** | **February 2, 2023** |
| **Requested Time:** | **4:00 P.M. Eastern Time** |

---

Ladies and Gentlemen:

In accordance with Rule 461 of the Securities Act of 1933, as amended (the "**Securities Act**"), we, as representatives of the several underwriters (the "**Representatives**"), hereby join in the request of Structure Therapeutics Inc., an exempted company with limited liability incorporated under the laws of the Cayman Islands (the "**Registrant**"), that the effectiveness of the above-captioned Registration Statement, as amended, be accelerated to 4:00 p.m. Eastern Time on February 2, 2023, or as soon thereafter as practicable, or at such other time as the Registrant or its outside counsel, Cooley LLP, request by telephone that such Registration Statement be declared effective.

Pursuant to Rule 460 under the Securities Act, please be advised that we will take reasonable steps to secure adequate distribution of the preliminary prospectus, to underwriters, dealers, institutions and others, prior to the requested effective time of the Registration Statement.

We, the undersigned Representatives, have and will, and we have been informed by the participating underwriters that they have and will, comply with the requirements of Rule 15c2-8 under the Securities Exchange Act of 1934, as amended, in connection with the proposed offering.

[*Remainder of page intentionally left blank*]

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| | |
|:---|:---|
| Very truly yours, | Very truly yours, |
| Acting severally on behalf of themselves and the several underwriters | Acting severally on behalf of themselves and the several underwriters |
| **JEFFERIES LLC** | **JEFFERIES LLC** |
| **SVB SECURITIES LLC** | **SVB SECURITIES LLC** |
| **GUGGENHEIM SECURITIES, LLC** | **GUGGENHEIM SECURITIES, LLC** |
| **BMO CAPITAL MARKETS CORP.** | **BMO CAPITAL MARKETS CORP.** |
| **JEFFERIES LLC** | **JEFFERIES LLC** |
| By: | /s/ Bryan Czyzewski |
| Name: Bryan Czyzewski | Name: Bryan Czyzewski |
| Title: Managing Director | Title: Managing Director |
| **SVB SECURITIES LLC** | **SVB SECURITIES LLC** |
| By: | /s/ Dan Dubin |
| Name: Dan Dubin | Name: Dan Dubin |
| Title: Vice Chairman, Global Co-Head of Healthcare Investment Banking | Title: Vice Chairman, Global Co-Head of Healthcare Investment Banking |
| **GUGGENHEIM SECURITIES, LLC** | **GUGGENHEIM SECURITIES, LLC** |
| By: | /s/ Shiv Taylor M.D. |
| Name: Shiv Taylor M.D. | Name: Shiv Taylor M.D. |
| Title: Senior Managing Director | Title: Senior Managing Director |
| **BMO CAPITAL MARKETS CORP.** | **BMO CAPITAL MARKETS CORP.** |
| By: | /s/ Marc Ogborn |
| Name: Marc Ogborn | Name: Marc Ogborn |
| Title: Managing Director | Title: Managing Director |

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[*Signature Page to Underwriters' Acceleration Request Letter*]