# EDGAR Filing Document

**Accession Number:** 0001571934
**File Stem:** 0001104659-26-000219
**Filing Date:** 2026-1
**Character Count:** 19660
**Document Hash:** e1bcd110ecbe565948ac88529470d9a2
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-26-000219.hdr.sgml**: 20260102

**ACCESSION NUMBER**: 0001104659-26-000219

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 17

**FILED AS OF DATE**: 20260102

**EFFECTIVENESS DATE**: 20260102

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** TAO Synergies Inc.
- **CENTRAL INDEX KEY:** 0001571934
- **STANDARD INDUSTRIAL CLASSIFICATION:** FINANCE SERVICES [6199]
- **ORGANIZATION NAME:** 09 Crypto Assets
- **EIN:** 461585656
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-292563
- **FILM NUMBER:** 26502835

**BUSINESS ADDRESS:**
- **STREET 1:** 1185 AVENUE OF THE AMERICAS, 3RD FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10036
- **BUSINESS PHONE:** 9732420005

**MAIL ADDRESS:**
- **STREET 1:** 1185 AVENUE OF THE AMERICAS, 3RD FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10036

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Synaptogenix, Inc.
- **DATE OF NAME CHANGE:** 20201210

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** NEUROTROPE BIOSCIENCE, INC.
- **DATE OF NAME CHANGE:** 20130312

**As filed with the Securities and Exchange Commission on January 2, 2026** 

**Registration No. 333-**

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**WASHINGTON, D.C. 20549**

------

**FORM S-8**

**REGISTRATION STATEMENT**

***UNDER***

***THE SECURITIES ACT OF 1933***

 ****

 ****

**TAO Synergies Inc.**

**(Exact name of registrant as specified in its charter)**

---

| | |
|:---|:---|
| Delaware | 46-1585656 |
| **(State or other jurisdiction of<br> incorporation or organization)** | **(I.R.S. Employer**<br> **Identification Number)** |
| 1185 Avenue of the Americas, 3<sup>rd</sup> Floor<br> New York, NY <br> **(Address of Principal Executive Offices)** | 10036**<br> (Zip Code)** |

---

TAO Synergies Inc. 2020 Equity Incentive Plan

**(Full title of the plan)**

Robert Weinstein

Chief Financial Officer

TAO Synergies Inc.

1185 Avenue of the Americas, 3<sup>rd</sup> Floor

New York, NY 1003

**(Name and address of agent for service)**

(973) 242-0005

**(Telephone number, including area code, of agent for service)**

***With a copy to:***

 ****

**Kenneth R. Koch, Esq.**

**Jeffrey D. Cohan, Esq.**

**Mintz, Levin, Cohn, Ferris, Glovsky & Popeo, P.C.**

**919 Third Avenue**

**New York, New York 10022**

**212-935-3000**

------

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

Large accelerated filer ◻ Accelerated filer ◻ <br> Non-accelerated filer ⌧ Smaller reporting company ⌧ <br> Emerging growth company ◻

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ◻If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ◻

**EXPLANATORY NOTE**

This Registration Statement on Form S-8 is filed to register an additional 500,000 shares of common stock, par value $0.0001 per share, of TAO Synergies Inc. (the "Registrant") reserved for issuance under the Registrant's 2020 Equity Incentive Plan (the "2020 Plan"), which were added to the shares authorized for issuance under the 2020 Plan pursuant to an amendment to the 2020 Plan adopted by the Registrant's stockholders on December 18, 2025. This Registration Statement registers additional securities of the same class as other securities for which prior registration statements filed on Form S-8 of the Registrant relating to an employee benefit plan are effective (File Nos. 333-289613, 333-268518 and 333-258807). The information contained in the Registrant's Registration Statements on Form S-8 filed with the Securities and Exchange Commission on August 14, 2025 ([File No. 333-289613](http://www.sec.gov/Archives/edgar/data/1571934/000110465925078733/tm2523496d1_s8.htm)), November 22, 2022 ([File No. 333-268518](http://www.sec.gov/Archives/edgar/data/1571934/000110465922121207/tm2231119d1_s8.htm)) and August 13, 2021 ([File No. 333-258807](http://www.sec.gov/Archives/edgar/data/1571934/000110465921105106/tm2124622d1_s8.htm)) is hereby incorporated by reference pursuant to General Instruction E of Form S-8.

**PART II**

**INFORMATION REQUIRED IN THE REGISTRATION STATEMENT**

**Item 8.** **Exhibits.**

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| | | | | | |
|:---|:---|:---|:---|:---|:---|
| **Exhibit** <br> **Number** | **Exhibit Description** | **Filed** <br> **Herewith** | **Incorporated** <br> **by <br> Reference** <br> **herein <br> from** <br> **Form or** <br> **Schedule** | **Filing <br> Date** | **SEC File/** <br> **Reg. <br> Number** |
| [4.1](https://www.sec.gov/Archives/edgar/data/1571934/000110465920119650/tm2024584d7_ex4-5.htm) | [Form of Common Stock Certificate of the Registrant](https://www.sec.gov/Archives/edgar/data/1571934/000110465920119650/tm2024584d7_ex4-5.htm) |  | [Form S-1/A (Exhibit 4.5)](https://www.sec.gov/Archives/edgar/data/1571934/000110465920119650/tm2024584d7_ex4-5.htm) | [11/05/2020](https://www.sec.gov/Archives/edgar/data/1571934/000110465920119650/tm2024584d7_ex4-5.htm) | [333-249434](https://www.sec.gov/Archives/edgar/data/1571934/000110465920119650/tm2024584d7_ex4-5.htm) |
| [5.1](tm2534171d1_ex5-1.htm) | [Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. as to the legality of the securities being registered](tm2534171d1_ex5-1.htm) | [X](tm2534171d1_ex5-1.htm) |  |  |  |
| [23.1](tm2534171d1_ex23-1.htm) | [Consent of Stephano Slack LLC](tm2534171d1_ex23-1.htm) | [X](tm2534171d1_ex23-1.htm) |  |  |  |
| [23.2](tm2534171d1_ex23-2.htm) | [Consent of Morison Cogen LLP](tm2534171d1_ex23-2.htm) | [X](tm2534171d1_ex23-2.htm) |  |  |  |
| [23.3](tm2534171d1_ex5-1.htm) | [Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. (included in Exhibit 5.1)](tm2534171d1_ex5-1.htm) | [X](tm2534171d1_ex5-1.htm) |  |  |  |
| [24.1](#poa) | [Power of Attorney (included on signature page to this Registration Statement)](#poa) | [X](#poa) |  |  |  |
| [107](tm2534171d1_exfilingfees.htm) | [Filing Fee Table](tm2534171d1_exfilingfees.htm) | [X](tm2534171d1_exfilingfees.htm) |  |  |  |

---

**SIGNATURES**

Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of New York, New York, on January 2, 2026.

---

| | |
|:---|:---|
| **TAO SYNERGIES INC.** | **TAO SYNERGIES INC.** |
| By: | /s/ Robert Weinstein |
| Name: | Robert Weinstein |
| Title: | Chief Financial Officer |
|  | (principal financial officer and principal accounting officer) |

---

**POWER OF ATTORNEY**

KNOW ALL BY THESE PRESENTS, that each of the directors and officers of TAO Synergies Inc. whose signature appears below hereby severally constitutes and appoints Joshua Silverman and Robert Weinstein, and each of them singly, his true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution in each of them singly, for him and in his name, place and stead, and in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement on Form S-8 of TAO Synergies Inc., and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting to said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite or necessary to be done in or about the premises, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents or any of them or their substitute may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statement has been signed by the following persons in the capacities and on the date indicated.

---

| | | |
|:---|:---|:---|
| **Signature** | **Title** | **Date** |
| /s/ Joshua N. Silverman | Director and Executive Chairman of the Board |  |
| Joshua N. Silverman | (Principal Executive Officer) | January 2, 2026 |
| /s/ Robert Weinstein | Chief Financial Officer |  |
| Robert Weinstein | (Principal Financial Officer and Principal Accounting Officer) | January 2, 2026 |
| /s/ Bruce T. Bernstein<br> Bruce T. Bernstein | Director and Vice-Chairman of the Board | January 2, 2026 |
| /s/ William S. Singer | Director | January 2, 2026 |
| William S. Singer |  |  |
| /s/ Robert Ephron<br> Robert Ephron | Director | January 2, 2026 |

---

## Exhibit 5.1

**Exhibit 5.1**

---

| | |
|:---|:---|
| ![](tm2534171d1_ex5-1img001.jpg) | <br> 919 Third Avenue<br> New York, NY 10022 <br> 212 935 3000<br> mintz.com |

---

January 2, 2026

TAO Synergies Inc.

1185 Avenues of the Americas, 3<sup>rd</sup> Floor

New York, NY 10036

Re: Registration Statement on Form S-8

Ladies and Gentlemen:

We have acted as legal counsel to TAO Synergies Inc., a Delaware corporation (the "Company"), in connection with the preparation and filing with the Securities and Exchange Commission (the "Commission") of a Registration Statement on Form S-8 (the "Registration Statement"), pursuant to which the Company is registering the issuance under the Securities Act of 1933, as amended (the "Securities Act"), of an aggregate of 500,000 shares (the "Shares") of the Company's common stock, par value $0.0001 per share, that may be issued pursuant to the Company's 2020 Equity Incentive Plan, as amended (the "2020 Plan"). This opinion is being rendered in connection with the filing of the Registration Statement with the Commission. All capitalized terms used herein and not otherwise defined shall have the respective meanings given to them in the Registration Statement.

In connection with this opinion, we have examined the Company's Amended and Restated Certificate of Incorporation and Amended and Restated Bylaws, each as currently in effect; such other records of the corporate proceedings of the Company and certificates of the Company's officers as we have deemed relevant; and the Registration Statement and the exhibits thereto.

In our examination, we have assumed the genuineness of all signatures, the legal capacity of natural persons, the authenticity of all documents submitted to us as originals, the conformity to original documents of all documents submitted to us as copies, the authenticity of the originals of such copies, and the truth and correctness of any representations and warranties contained therein. In addition, we have assumed that the Company will receive any required consideration in accordance with the terms of the 2020 Plan.

Our opinion expressed herein is limited to the General Corporation Law of the State of Delaware and we express no opinion with respect to the laws of any other jurisdiction. No opinion is expressed herein with respect to the qualification of the Shares under the securities or blue sky laws of any state or any foreign jurisdiction.

Please note that we are opining only as to the matters expressly set forth herein, and no opinion should be inferred as to any other matters. This opinion is based upon currently existing statutes, rules, regulations and judicial decisions, and we disclaim any obligation to advise you of any change in any of these sources of law or subsequent legal or factual developments which might affect any matters or opinions set forth herein.

Based upon the foregoing, we are of the opinion that the Shares, when issued and delivered in accordance with the terms of the 2020 Plan, will be validly issued, fully paid and non-assessable.

Boston Los Angeles New York San Diego San Francisco Washington TORONTO

MINTZ, LEVIN, COHN, FERRIS, GLOVSKY AND POPEO, P.C.

---

| | |
|:---|:---|
| MINTZ | ![](tm2534171d1_ex5-1img002.jpg) |

---

January 2, 2026

We understand that you wish to file this opinion with the Commission as an exhibit to the Registration Statement in accordance with the requirements of Item 601(b)(5) of Regulation S-K promulgated under the Securities Act, and we hereby consent thereto. In giving this consent, we do not admit that we are within the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations of the Commission promulgated thereunder.

---

| |
|:---|
| Very truly yours, |
| <u>/s/ Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.</u> |
| Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. |

---

## Exhibit 23.1

Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in this Registration Statement on Form S-8 of TAO Synergies Inc. (formerly Synaptogenix, Inc.) of our report dated March 27, 2025, with respect to our audit of the financial statements of TAO Synergies Inc. as of December 31, 2024 and for the year then ended, which report appears in the Annual Report on Form 10-K of TAO Synergies Inc. for the year ended December 31, 2024.

/s/ Stephano Slack LLC

Wayne, Pennsylvania

January 2, 2026

## Exhibit 23.2

**Exhibit 23.2** 

**CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM**

We hereby consent to the incorporation by reference in the Registration Statement on Form S-8 of our report dated April 1, 2024 with respect to our audit of the financial statements of Synaptogenix, Inc. as of December 31, 2023 and for the year ended December 31, 2023.

/s/ Morison Cogen LLP

Blue Bell, Pennsylvania

January 2, 2026

## Ex-Filing

?xml version='1.0' encoding='ASCII'? EX-FILING FEES

---

| |
|:---|
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Calculation of Filing Fee Tables**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **S-8**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **TAO Synergies Inc.**  |

---

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| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Security Type**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Security Class Title**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Fee Calculation Rule**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Amount Registered**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Proposed Maximum Offering Price Per Unit**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Maximum Aggregate Offering Price**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Fee Rate**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Amount of Registration Fee**  |
| 1 | Equity | Common stock, par value $0.0001 per share | 457(a) | 500000 | $4.44 | $2220000.00 | 0.0001381 | $306.58 |
| Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: |  | $2220000.00  |  | $306.58  |
| Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  |  |  |  | $0.00  |
| Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  |  |  |  | $306.58  |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Offering Note** <br>

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <sup>1</sup> (1) The number of shares of common stock, par value $0.0001 per share ("common stock"), of TAO Synergies Inc. (the "Registrant") stated above consists of additional shares of common stock available for issuance under the Registrant's 2020 Equity Incentive Plan (the "2020 Plan"), added pursuant to an amendment to the 2020 Plan adopted by the Registrant's stockholders on December 18, 2025. The maximum number of shares which may be sold upon exercise of options or issuance of stock-based awards granted under the 2020 Plan, as amended, is subject to adjustment in accordance with certain anti-dilution and other provisions of the 2020 Plan, as amended. Accordingly, pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this registration statement covers, in addition to the number of shares stated above, an indeterminate number of shares which may be subject to grant or otherwise issuable after the operation of any such anti-dilution and other provisions. (2) Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(c) and Rule 457(h) promulgated under the Securities Act. The offering price per share and the aggregate offering price for shares reserved for future grant or issuance under the 2020 Plan, as amended, are based on the average of the high and the low price of Registrant's common stock as reported on The Nasdaq Capital Market as of a date (December 26, 2025) within five business days prior to filing this Registration Statement.

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| | |
|:---|:---|
| | |
| **Rule 457(p)** | **Rule 457(p)** |
| Fee Offset Claims | N/A |
| Fee Offset Sources | N/A |

---