# EDGAR Filing Document

**Accession Number:** 0001826457
**File Stem:** 0000950170-23-000436
**Filing Date:** 2023-1
**Character Count:** 36791
**Document Hash:** 078ecf1fb4dc27ad845e06f744d3d367
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000950170-23-000436.hdr.sgml**: 20230109

**ACCESSION NUMBER**: 0000950170-23-000436

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 57

**CONFORMED PERIOD OF REPORT**: 20230109

**ITEM INFORMATION**: Regulation FD Disclosure

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20230109

**DATE AS OF CHANGE**: 20230109

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Monte Rosa Therapeutics, Inc.
- **CENTRAL INDEX KEY:** 0001826457
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-40522
- **FILM NUMBER:** 23516585

**BUSINESS ADDRESS:**
- **STREET 1:** 645 SUMMER STREET
- **STREET 2:** SUITE 102
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02210
- **BUSINESS PHONE:** 617-949-2643

**MAIL ADDRESS:**
- **STREET 1:** 645 SUMMER STREET
- **STREET 2:** SUITE 102
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02210

?xml version="1.0" encoding="ASCII"? 8-K

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549** 

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**FORM** 8-K

**CURRENT REPORT**

**Pursuant to Section 13 or 15(d)**

**of the Securities Exchange Act of 1934**

**Date of Report (Date of earliest event reported):** January 9, 2023

MONTE ROSA THERAPEUTICS, INC.

**(Exact name of registrant as specified in its charter)** 

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| | | |
|:---|:---|:---|
| Delaware | 001-40522 | 84-3766197 |
| **(State or other jurisdiction<br>of incorporation)** | **(Commission<br>File Number)** | **(I.R.S. Employer<br>Identification No.)** |

---

645 Summer Street**,** Suite 102

Boston**,** MA 02210

**(Address of principal executive offices, including zip code)**

**(**617**)** 949-2643

**(Registrant's telephone number, including area code)**

**Not Applicable**

**(Former Name or Former Address, if Changed Since Last Report)** 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

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| | | |
|:---|:---|:---|
| **Title of each class** | **Trading<br>Symbol(s)** | **Name of each exchange<br>on which registered** |
| Common Stock, $0.0001 par value per share | GLUE | The Nasdaq Global Select Market |

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Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging growth company ☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

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**Item 7.01. Regulation FD Disclosure** 

On January 9, 2023, Monte Rosa Therapeutics, Inc. issued a press release titled "Monte Rosa Therapeutics Outlines Progress Across Portfolio of Molecular Glue Degraders and Key Anticipated Milestones for 2023" and provided a corporate update in conjunction with its participation at the 41st Annual J.P. Morgan Healthcare Conference in San Francisco, CA. The press release and presentation are furnished as Exhibit 99.1 and 99.2, respectively, to this Current Report on Form 8-K.

The information in this Form 8-K (including Exhibits 99.1 and 99.2) shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such a filing.

**Item 9.01. Financial Statements and Exhibits**

(d) Exhibits

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| | |
|:---|:---|
| 99.1 | [<u>J.P. Morgan Healthcare Conference presentation furnished by Monte Rosa Therapeutics, Inc. on January 9, 2023.</u>](glue-ex99_1.htm) |
| 99.2 | [<u>Press release issued by Monte Rosa Therapeutics, Inc. on January 9, 2023, furnished herewith.</u>](glue-ex99_2.htm) |
| 104 | Cover Page Interactive Data File (embedded within the Inline XBRL document). |

---

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**SIGNATURE**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

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| | | |
|:---|:---|:---|
|  | Monte Rosa Therapeutics, Inc. | Monte Rosa Therapeutics, Inc. |
| Date: January 9, 2023 | By: | /s/ Markus Warmuth |
|  |  | Markus Warmuth |
|  |  | President and Chief Executive Officer |

---

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## Exhibit 99.1

![Slide 1](glue-ex99_1s1.jpg)

From Serendipity to Rational Design Taking Molecular Glue Degraders to New Heights \| January 2023

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![Slide 2](glue-ex99_1s2.jpg)

Forward-Looking Statements These materials include express and implied "forward-looking statements," including forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward looking statements include all statements that are not historical facts, and in some cases, can be identified by terms such as "may," "might," "will," "could," "would," "should," "expect," "intend," "plan," "objective," "anticipate," "believe," "estimate," "predict," "potential," "continue," "ongoing," or the negative of these terms, or other comparable terminology intended to identify statements about the future. Forward-looking statements contained in herein include, but are not limited to, statements about our product development activities, including our expectations around MRT-2359, such as for our ongoing clinical trial for MRT-2359 and the timing thereof and our expectations regarding the potential significance of obtaining Fast Track Designation from the FDA, the ongoing development of our QuEEN™ platform, the advancement, and timing thereof, of our pipeline and the various products therein, our ability to initiate and the timing of initiation of additional lead optimization programs, and our expectations regarding our ability to nominate and the timing of our nominations of additional development candidates, as well as our expectations of success for our programs and the strength of our financial position, among others. By their nature, these statements are subject to numerous risks and uncertainties, including the impact that the ongoing COVID-19 pandemic will have on our development activities and operations, as well as those risks and uncertainties set forth in our Annual Report on Form 10-K for the fourth quarter and full year ended December 31, 2021 filed, with the US Securities and Exchange Commission on March 29, 2022, and any subsequent filings, including our most recently filed Quarterly Report on Form 10-Q, that could cause actual results, performance or achievement to differ materially and adversely from those anticipated or implied in the statements. You should not rely upon forward looking statements as predictions of future events. Although our management believes that the expectations reflected in our statements are reasonable, we cannot guarantee that the future results, performance or events and circumstances described in the forward-looking statements will be achieved or occur. Recipients are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date such statements are made and should not be construed as statements of fact. We undertake no obligation to publicly update any forward-looking statements, whether as a result of new information, any future presentations or otherwise, except as required by applicable law. Certain information contained in these materials and any statements made orally during any presentation of these materials that relate to the materials or are based on studies, publications, surveys and other data obtained from third-party sources and our own internal estimates and research. While we believe these third-party studies, publications, surveys and other data to be reliable as of the date of these materials, we have not independently verified, and make no representations as to the adequacy, fairness, accuracy or completeness of, any information obtained from third-party sources. In addition, no independent source has evaluated the reasonableness or accuracy of our internal estimates or research and no reliance should be made on any information or statements made in these materials relating to or based on such internal estimates and research. These materials remain the proprietary intellectual property of Monte Rosa Therapeutics and should not be distributed or reproduced in whole or in part without the prior written consent of Monte Rosa Therapeutics.

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![Slide 3](glue-ex99_1s3.jpg)

Monte Rosa Therapeutics Highlights Taking molecular glue degraders (MGDs) to new heights Developing breakthrough drugs that selectively degrade therapeutically-relevant proteins previously considered undruggable AI-based degron prediction & rational design of highly selective MGDs enable a next-generation molecular glue-based targeted protein degradation platform Five disclosed programs targeting high unmet medical needs in oncology, autoimmune disease, inflammation and other indications PhI/II initiated for MRT-2359 with clinical development in MYC-driven tumors Strong financial position with $274M cash as of December 31, 2022, providing runway into 2025

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![Slide 4](glue-ex99_1s4.jpg)

World-Class Leadership Deep expertise in molecular glue discovery, drug development and precision medicine Jullian Jones, Ph.D., J.D., MBA Chief Business Officer Markus Warmuth, M.D. Chief Executive Officer Ajim Tamboli, CFA Chief Financial Officer John Castle, Ph.D. Chief Data Scientist Silvia Buonamici, Ph.D. SVP, Drug Discovery Biology Filip Janku, M.D., Ph.D. Chief Medical Officer Sharon Townson, Ph.D. Chief Technology Officer Owen Wallace, Ph.D. Chief Scientific Officer Phil Nickson, Ph.D., J.D. General Counsel Jennifer Champoux, SVP, Operations

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![Slide 5](glue-ex99_1s5.jpg)

Molecular Glue Degraders (MGDs) – Drugging The Undruggable Expanding target space, fostering a new generation of drugs Drugging the Druggable INHIBITOR Drugging the Undruggable MGDs Redrugging the Druggable PROTAC UNDRUGGABLE TARGETS E3 Ligase DRUGGABLE TARGETS E3 Ligase DRUGGABLE TARGETS Target Space Expanding the Degradable Proteome Favorable drug-like properties Broad tissue distribution No hook effect

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![Slide 6](glue-ex99_1s6.jpg)

QuEEN™ Discovery Engine Quantitative and Engineered Elimination of Neosubstrates

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![Slide 7](glue-ex99_1s7.jpg)

Our Rational Approach to Unleash the Full Potential of MGDs Beyond cereblon Beyond the canonical degrome Unraveling the canonical degrome Neosubstrates - Eg. IKZF1 MGD Eg. Lenalidomide Cereblon Expanding the Degradable Proteome Chemical Space Target Space Degron

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![Slide 8](glue-ex99_1s8.jpg)

QuEEN™ Discovery Engine: Unique Capabilities Enable Our Rational and Target-Centric Approach to MGDs Diverse and growing library rationally designed using structural insights to engage a variety of degrons Proprietary MGD library Glueomics™ Engine Specialized suite of in vitro assays to globally assess proximity and degradation proteome-wide and in high throughput AI Engines OneVision™ and Rhapsody™ In silico degron & ternary complex discovery using proprietary AI-powered algorithms Protein fold-change; (log2) p-value Integrated and iterative workflow leads to discovery of reprogrammable ligases, neosubstrates and MGDs

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![Slide 9](glue-ex99_1s9.jpg)

A CRBN-Centric Library Characterized by Novelty and Structural Diversity Chemical fingerprints of MGD hits Current library size 27K MGDs, continuing to expand High structural diversity and novelty Design focused on optimal drug-like properties Library characteristics Leveraging different areas of the CRBN surface to engage diverse degrons and targets Target A Target B Target C Target D MGDs

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![Slide 10](glue-ex99_1s10.jpg)

Omics Platforms Accelerate Degron and MGD Discovery and Validation Chemo-transcriptomics Chemo-proteomics p-value p-value Protein fold-change; (log2) Protein fold-change; (log2) Target A Target A Proximity (Turbo-ID) Degradation Proteome-wide profiling of up to 10K proteins to characterize MGD proximity, degradation and selectivity High-throughput transcriptomic profiling to characterize MGD pathway MOA, selectivity and structure-activity Pathway A Pathway B Pathway C Pathway D MGD chemical fingerprint tSNE

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![Slide 11](glue-ex99_1s11.jpg)

Proprietary AI/ML Engines Allow for Discovery of Glueable Targets and Highly Selective MGDs PPI propensity & pocket identification for reprogrammability Surface complementarity connecting E3 ligases to neosubstrates E3 ligase Candidate neosubstrates E3 ligase surface evaluation Proteome-wide glueability assessment Ternary complex modelling and in-silico screening Fast algorithms leveraging ensembles, dynamics and quantum mechanics E3 ligase Candidate neosubstrate MGD

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![Slide 12](glue-ex99_1s12.jpg)

A Rich, Differentiated Target Space Across Protein Domains and Diseases Degrons have unique sequences enabling design of MGDs with unprecedented level of selectivity QuEEN has enabled the discovery of diverse degrons across various protein domains and classes Degrons Selectivity Protein fold-change; (log2) p-value Our Degron Encyclopedia contains many highly credentialed, undruggable targets Targets

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![Slide 13](glue-ex99_1s13.jpg)

Portfolio

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![Slide 14](glue-ex99_1s14.jpg)

Targets Clinical Path Leveraging a Leading Drug Discovery Platform Purpose-built to discover and develop a wide landscape of therapeutically-relevant MGDs Undruggable and inadequately drugged degron-containing proteins Target non-catalytic and scaffolding functions High level of target validation, preclinically and clinically Programs with a biomarker-based patient selection strategy and a clear path to the clinic Opportunity for a rapid clinical PoC showing MOA and efficacy Address high unmet needs Drug a wide range of therapeutically-relevant proteins in oncology and beyond Create synergies within therapeutic areas Monte Rosa's High-Value Proprietary Pipeline Patient Benefit

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![Slide 15](glue-ex99_1s15.jpg)

Monte Rosa Pipeline Rapidly advancing wholly owned MGD programs targeting undruggable proteins Oncology Autoinflammation Oncology / immunology Genetic diseases GSPT1 (G-loop) NSCLC, SCLC and other MYC-driven Malignancies CDK2 (new) Ovarian Cancer, Breast Cancer NEK7 (G-loop) Inflammatory Diseases VAV1 (new) T and B Cell Malignancies, Autoimmune Disease Discovery Target (Degron) Indication(s) Initial clinical data disclosure in 2H 2023 Multiple SCD targets SCD, β-Thalassemia Next Anticipated Milestones Ownership Undisclosed Multiple IND-Enabling Clinical Lead optimization Multiple development candidate nominations in 2H 2023

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![Slide 16](glue-ex99_1s16.jpg)

GSPT1 Program

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![Slide 17](glue-ex99_1s17.jpg)

MYC Family Transcription Factors are Key Cancer Dependence Genes MYC up-regulation dysregulates key cellular processes (e.g. ribosome biogenesis and protein synthesis) MYC dysregulation is frequently associated with poor prognosis and unfavorable patient survival MYC family: c-MYC, N-MYC, and L-MYC MYCs are considered undruggable by classic methods Cells expressing high MYC are sensitive to MYC CRISPR KO MYC family members are amongst the most dysregulated oncogenes in human cancer DepMap data, each dot represents a cell line NSCLC N-MYC SCLC L-MYC

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![Slide 18](glue-ex99_1s18.jpg)

Oncogene addiction MRT-2359 impairs protein synthesis in MYC high lines Synthetic lethality MRT-2359 affects MYC and targets in MYC high lines Targeting MYC-driven Tumors and Their Addiction to Protein Translation Through Degradation of GSPT1 To sustain growth, MYC-driven tumors are addicted to protein translation This addiction creates a dependency on the translation termination factor GSPT1 GSPT1-directed MGD

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![Slide 19](glue-ex99_1s19.jpg)

QuEEN™ Discovery Engine Facilitates the Design of MRT-2359 Diverse library, rationally designed, using structural insights to engage a variety of degrons In silico ternary complex modelling using proprietary AI-powered algorithms in vitro data CRBN binding, Ki 113 nM Ternary complex, EC50 < 7 nM Degradation, DC50 80 nM Degron MRT-2359 GSPT1 CRBN Rhapsody™ MRT-2359 is a potent GSPT1 degrader Proprietary MGD library

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![Slide 20](glue-ex99_1s20.jpg)

MRT-2359 is a GSPT1-directed MGD with Favorable Drug-like Properties GAPDH IKZF1 IKZF3 ZFP91 CK1a GSPT1 - 0.3 3 30 30 30 6hr post treatment in MM1S and Kelly (SALL4) - - - - + - - - - - - + SALL4 1hr post treatment Protein fold-change; (log2) p-value MRT-2359, mM Bortezomib MLN-4924 Proximity – Turbo ID MRT-2359 is orally bioavailable and has favorable ADMET profile MRT-2359 is a selective GSPT1-directed MGD ADMET profile CYP DDIs > 30 µM hERG inhibition patch clamp EC50 > 30 µM Oral bioavailability all species ~50% MRT-2359 does not inhibit or induce major CYPs MRT-2359 does not inhibit hERG MRT-2359 is orally bioavailable

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![Slide 21](glue-ex99_1s21.jpg)

Preferential Activity of MRT-2359 in MYC-Driven NSCLC Lines MRT-2359 induces GSPT1 degradation in all cell models, but show preferential antiproliferative activity in N-MYC high cell lines Viability GSPT1 western blot at 6 hr (N-Myc high) and 24 hr (low). 72 hr viability assay (CTG) GSPT1 degradation N-MYC overexpression sensitizes NCI-H2023 resistant cells to MRT-2359 Incucyte, 96 hr post treatment Doxycycline-inducible N-MYC model Low N-MYC NCI-H2023 NCI-H441 High N-MYC NCI-H1155 ABC-1 - Dox + Dox Wash-out NCI-H2023 Dox-inducible MYC + Dox NCI-H2023 Dox-inducible MYC - Dox NCI-H2023 Dox-inducible MYC + Dox wash-out GAPDH N-MYC - + Wash-out Dox - - + +

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![Slide 22](glue-ex99_1s22.jpg)

N-MYC high NSCLC lines MRT-2359 Shows Preferential Activity in MYC High or Neuroendocrine (NE) Positive Cancer Lines Low L-MYC NCI-H2286 NCI-H196 High L-MYC NCI-H1836 NCI-H1876 72 hr viability assay (CTG) L-MYC high SCLC lines NE positive lung lines Low NE High NE Low N-MYC NCI-H2023 NCI-H441 High N-MYC NCI-H1155 ABC-1 NCI-H2405 NCI-H1693 NCI-H810 NCI-H1770

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![Slide 23](glue-ex99_1s23.jpg)

MRT-2359 Mouse-trial in NSCLC, SCLC and Lung NE Patient-derived Xenografts Models selected across a range of N-MYC and L-MYC mRNA expression levels or NE status were treated with: Vehicle MRT-2359 10 mg/kg PO QD 3 mice for each treatment group Collection of PDX models All models have been characterized by DNA and RNAseq SCLC NSCLC Large cell NE carcinoma or NE lung cancer N-MYC mRNA expression Log2 (TPM+1) N-MYC mRNA expression Log2 (TPM+1) L-MYC mRNA expression Log2 (TPM+1) L-MYC mRNA expression Log2 (TPM+1) Selected 20 models Selected 48 models Selected 10 models NE genes 23 Log2 FPKM Models L-MYC and N-MYC low L-MYC or N-MYC high

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![Slide 24](glue-ex99_1s24.jpg)

MRT-2359 Demonstrates Preferential Anti-tumor Activity in MYC High or Neuroendocrine (NE) Lung Cancer PDXs NSCLC SCLC NE Lung Cancer L-MYC and N-MYC low L-MYC or N-MYC high MRT-2359 10 mg/kg, PO, QD Large cell NE carcinoma or NE lung cancer N-MYC and L-MYC low

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![Slide 25](glue-ex99_1s25.jpg)

Dose level 1 MTD or RP2D Phase 2: Expansion Cohorts Phase 1: Dose Escalation NSCLC\* – high N- or L-MYC expression – low N- and L-MYC expression Backfill slots for additional patients for each dose level Backfill Dose level 2 Dose level 3 Dose level X Backfill Backfill \* Efficacy guided stratification per N-/L-MYC expression Solid tumors – N- or L-MYC amplification Lung cancer (NSCLC & SCLC), DLBCL, high-grade neuroendocrine tumors, and N-/L-MYC amplified solid tumors SCLC\* – high N- or L-MYC expression – low N- and L-MYC expression MRT-2359-001 Clinical Study Design Patient dosing initiated in October 2022

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![Slide 26](glue-ex99_1s26.jpg)

Targeting L-/N-MYC positive and Neuroendocrine Tumors with MRT-2359 Patient diagnosed incidence #s, major markets (US, EU and JP): Decision Resources Group (DRG) % population based on preliminary internal cut offs for high vs low expression applied to real world data provided by Tempus 26 Small cell lung cancer 66K patients – 70% MYC high Non-small cell lung cancer 352K patients – 15% MYC high Neuroendocrine lung cancer Neuroendocrine prostate cancer Triple-negative breast cancer Ovarian cancer Bladder cancer Endometrial cancer c-MYC driven indications being further explored in preclinical translational studies Current focus Future options

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![Slide 27](glue-ex99_1s27.jpg)

CDK2 Program

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![Slide 28](glue-ex99_1s28.jpg)

CDK2 as a Target for Selected Solid Tumors Therapeutic hypothesis: Tumors with CDK2 pathway activation by: High CyclinE1/E2 expression Loss of RB Clinical Opportunity: CDK2 driven cancers: ER positive breast cancer pre and post treatment with CDK4/6 inhibitors (444K patients), ovarian cancer (63K patients), and endometrial cancer (118K patients) CDK2 is one of the key regulators of the cell cycle

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![Slide 29](glue-ex99_1s29.jpg)

CDK2-directed MGD Shows Selective Degradation Over the Other CDKs NanoBiT assay (24hr) - HEK293 CDK2-directed MGD induces CDK2 degradation CDK2-directed MGDs are selective over other CDKs TMT Proteomics (24hr) – HEK293 p-value (-log10) Protein fold-change (log2) CDKs CDK2

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![Slide 30](glue-ex99_1s30.jpg)

CDK2-directed MGD Shows Biological Activity in a CDK2-dependent Cell Line CDK2 degradation results in reduction of E2F pathway proteins CDK2-directed MGD inhibits proliferation of CDK2 dependent cells TMT Proteomics (24 hr) – MDA-MB-157 p-value (-log10) Protein fold-change (log2) E2F target genes CDK2 CDC6 CDK2 degradation arrests CDK2-dependent cells in G1 phase CyQuant assay (7d) – MDA-MB-157 CDK2-directed MGD Cell cycle profile (48hr) – MDA-MB-157 G1 phase S phase G2/M phases

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![Slide 31](glue-ex99_1s31.jpg)

VAV1 Program

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![Slide 32](glue-ex99_1s32.jpg)

Multiple CRISPR screens identified VAV1 as key player in T-cell function TCR = T-cell receptor VAV1 controls several aspects of T-cell activity VAV1 is a Highly Validated Target for Attenuating T-cell Activity Schmidt et al., Science 2022 Primary human T cells

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![Slide 33](glue-ex99_1s33.jpg)

Human primary pan-T cells TCR stimulation = α-CD3/CD28 MGD-induced degradation of VAV1 results in inhibition of TCR-mediated CD69 activation, IL-2 secretion, and proliferation IL-2 secretion Proliferation CD69 activation Discovery of Highly Selective VAV1-directed MGDs Protein fold-change (log2) p-value (-log10) VAV1 VAV1 protein Degron predicted and confirmed VAV1 domain MGD CRBN Predicted degron VAV3 VAV2

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![Slide 34](glue-ex99_1s34.jpg)

VAV1-directed MGD Inhibits Disease Progression in an EAE Mouse Model MGD inhibits disease progression in experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis MGD induces VAV1 degradation in PBMCs after a single oral dose in mice Additional autoimmune and immunology disease models are currently under evaluation EAE induced by MOG35-55 injection on day 0 Treatment started on day 12 Single dose 10 mg/kg PO

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![Slide 35](glue-ex99_1s35.jpg)

NEK7 Program

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![Slide 36](glue-ex99_1s36.jpg)

NEK7 (NIMA-Related Kinase 7) as a Target for Inflammatory Disease NEK7 is an essential regulator of the inflammasome Pyroptosis Gasdermin D Active NLRP3 inflammasome Cytokines secretion Pro-IL-1β Pro-IL-18 IL-18 IL-1β NEK7 NLRP3 Pro-Caspase-1 ASC N-terminal C-terminal N-terminal Caspase-1 N-terminal Therapeutic hypothesis: Diseases with over-activated or mutated NLRP3 inflammasome NEK7 licenses NLRP3 assembly in a kinase independent manner NEK7-deficient macrophages are severely impaired in IL-1β and IL-18 secretion Clinical opportunity: First-in-class NEK7 degraders for Over-activated NLRP3 inflammasome: metabolic pathologies, cardiovascular diseases, inflammatory issues and neurologic disorders NLRP3 activating mutations: Cryopyrin-associated periodic syndromes (CAPS)

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![Slide 37](glue-ex99_1s37.jpg)

NEK7-directed MGDs modulate NLRP3 Pathway in human macrophages p-value (-log10) Protein fold-change (log2) TMT Proteomics (24hr) – U937 IL-1b and IL-18 release (24hr) - human macrophages LPS/MSU stimulated NEK7-directed MGD shows high selectivity NEK7-directed MGD compared to NLRP3 inhibitor IL-1b secretion IL-18 secretion NEK7-directed MGD MCC950 – NLRP3i NEK7 NEKs

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![Slide 38](glue-ex99_1s38.jpg)

Sickle Cell Disease Program

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![Slide 39](glue-ex99_1s39.jpg)

Transcriptional Repressors as Targets for Hemoglobinopathies (SCD and β-Thalassemia) Therapeutic hypothesis: To reactivate expression of fetal hemoglobin (HbF) to compensate for mutated adult globin Clinical Opportunity: First-in-class degraders for Sickle cell disease (SCD) 155,000 patients (US and EU) >6M patients (ROW) β-thalassemia 17,000 patients (US and EU) Zinc finger domain-containing transcriptional repressors of the fetal globin genes Patient diagnosed prevalence #s: DRG; www.notaloneinsicklecell.com

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![Slide 40](glue-ex99_1s40.jpg)

Summary

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![Slide 41](glue-ex99_1s41.jpg)

Monte Rosa Therapeutics From serendipity to rational design of MGDs Proprietary, target-centric drug discovery platform enabling rational design, and anticipated rapid development, of molecular glue-based degraders targeting the undruggable proteome in oncology and non-oncology disease Extensive and compelling pre-clinical in vivo data for GSPT1 program, demonstrating potent anti-tumor activity in MYC-driven tumor models with development candidate MRT-2359 Molecular glue-based targeted protein degradation platform developing breakthrough therapeutics that selectively degrade disease-causing proteins Phase 1/2 trial with MRT-2359 for the treatment of MYC-driven tumors including lung cancer patients ongoing Initial platform focus on cereblon-mediated protein degradation with hundreds of potential targets to address; potential to reprogram other E3 ligases to access more of the undruggable proteome through other degrons CDK2, NEK7, and VAV1 programs in lead optimization with additional programs at various stages of discovery

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![Slide 42](glue-ex99_1s42.jpg)

Thank You

## Exhibit 99.2

![img107725713_0.jpg](img107725713_0.jpg)

**Monte Rosa Therapeutics Outlines Progress Across Portfolio of Molecular Glue Degraders and Key Anticipated Milestones for 2023**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•MRT-2359 received Fast Track designation from the FDA for the treatment of patients with previously treated, metastatic non-small cell lung cancer (NSCLC) with L-MYC or N-MYC expression

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Disclosure of initial data from Phase 1 arm of ongoing Phase 1/2 clinical trial evaluating MRT-2359 expected in second half of 2023

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Nomination of multiple additional development candidates anticipated in 2023

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;•Company to present pipeline and corporate updates at 41<sup>st</sup> Annual J.P. Morgan Healthcare Conference on Wednesday, Jan. 11, 2023, at 11:15 a.m. PT

**BOSTON, January 9, 2023** – Monte Rosa Therapeutics, Inc. (NASDAQ: GLUE), a biotechnology company developing novel molecular glue degrader (MGD)-based medicines, today outlined anticipated 2023 milestones ahead of its participation at the 41<sup>st</sup> Annual J.P. Morgan Healthcare Conference. The company's presentation will focus on strategic priorities for 2023, including its plans to report initial data from the Phase 1 arm of its ongoing Phase 1/2 clinical trial for MRT-2359, a highly selective and orally available GSPT1-directed MGD. Further, the company will present its development plan for its additional MGD candidates for patients with high unmet medical needs in oncology, autoimmune and inflammatory indications.

"In 2022, we made significant progress across our portfolio of highly selective molecular glue degraders, culminating in the initiation of our Phase 1/2 trial of MRT-2359 in MYC-driven tumors," said Markus Warmuth, M.D., CEO of Monte Rosa. "As we look ahead to 2023, with our lead program in the clinic, a rich pipeline of wholly owned preclinical programs, and backed by a strong cash position, we believe we are well positioned for success. We expect our programs to achieve important catalysts in 2023 that will bring us closer to fulfilling our vision of developing a new generation of MGD-based precision medicines for patients living with serious diseases."

**<u>2023 Key Milestones and Catalysts</u>**

• The U.S. Food and Drug Administration (FDA) has granted Fast Track designation to MRT-2359 for the treatment of patients with previously treated, metastatic NSCLC with L-MYC or N-MYC expression

• The company anticipates disclosing initial data from the Phase 1 arm of the ongoing Phase 1/2 clinical trial evaluating MRT-2359 in the second half of 2023

• The company anticipates the nomination of multiple development candidates in 2023 for its programs oncology, autoimmune and inflammatory diseases

**J.P. Morgan Healthcare Conference**<br>Dr. Warmuth will present Monte Rosa's pipeline and business updates during a presentation at the 41<sup>st</sup>Annual J.P. Morgan Healthcare Conference on Wednesday, January 11, 2023, at 11:15 a.m. PT. An archived webcast of the presentation will be made available via the "Events & Presentations" section of the company's investor site at https://ir.monterosatx.com/.

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**About MRT-2359**

MRT-2359 is a potent, selective and orally bioavailable molecular glue degrader (MGD) that induces the interaction between the E3 ubiquitin ligase component cereblon and the translation termination factor GSPT1, leading to the targeted degradation of GSPT1 protein. The MYC transcription factors (c-MYC, L-MYC and N-MYC) are well-established drivers of human cancers that maintain high levels of protein translation, which is critical for uncontrolled cell proliferation and tumor growth. Our preclinical studies have shown that this addiction to MYC-induced protein translation creates a dependency on GSPT1. By inducing degradation of GSPT1, MRT-2359 exploits this vulnerability, disrupting the protein synthesis machinery and leading to anti-tumor activity in MYC-driven tumors.

**About the MRT-2359 Phase 1/2 study**

Our ongoing Phase 1/2, open-label, multicenter study (Identifier: NCT05546268) will primarily assess the safety, tolerability, pharmacokinetic (PK), pharmacodynamic (PD), and preliminary clinical activity of MRT-2359 in patients with previously treated selected solid tumors, including non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC), high-grade neuroendocrine cancer of any primary site, diffuse large B-cell lymphoma (DLBCL) and solid tumors with L-MYC or N-MYC amplification. In the Phase 1 portion of the study, patients will receive escalating doses of MRT-2359 to determine the maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D). Once the MTD and/or RP2D are determined, the anti-tumor activity of MRT-2359 will be assessed as part of the Phase 2 portion of the study, which includes L-MYC or N-MYC expression for stratification and selection.

**About Monte Rosa**

Monte Rosa Therapeutics is a biotechnology company developing novel molecular glue degrader (MGD) medicines for patients living with serious diseases such as oncology, autoimmune and inflammatory diseases. MGDs are small molecule protein degraders designed to employ the body's natural mechanisms to selectively eliminate therapeutically relevant proteins. The company's QuEEN™ (Quantitative and Engineered Elimination of Neosubstrates) platform enables it to rapidly identify protein targets and design highly selective degraders by combining diverse libraries of proprietary MGDs with in-house proteomics, structural biology, AI/machine learning, and computational chemistry capabilities. For more information, visit www.monterosatx.com

**Forward-Looking Statements**<br> This communication includes express and implied "forward-looking statements," including forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward looking statements include all statements that are not historical facts, and in some cases, can be identified by terms such as "may," "might," "will," "could," "would," "should," "expect," "intend," "plan," "objective," "anticipate," "believe," "estimate," "predict," "potential," "continue," "ongoing," or the negative of these terms, or other comparable terminology intended to identify statements about the future. Forward-looking statements contained in herein include, but are not limited to, statements about our product development activities, including our expectations around MRT-2359 and the potential significance of obtaining Fast Track Designation from the FDA, the ongoing development of our QuEEN™ platform and the advancement of our pipeline and the various products therein, our expectations regarding and the timing of our clinical trial for MRT-2359, our ability to initiate and the timing of initiation of additional lead optimization programs, and our expectations regarding our ability to nominate and the timing of our nominations of additional development candidates, as well as our

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expectations of success for our programs and the strength of our financial position, among others. By their nature, these statements are subject to numerous risks and uncertainties, including the impact that the ongoing COVID-19 pandemic will have on our development activities and operations, as well as those risks and uncertainties set forth in our most recent Quarterly Report on Form 10-Q and Annual Report on Form 10-K for the year ended December 31, 2021 filed with the US Securities and Exchange Commission, and any subsequent filings, that could cause actual results, performance or achievement to differ materially and adversely from those anticipated or implied in the statements. You should not rely upon forward looking statements as predictions of future events. Although our management believes that the expectations reflected in our statements are reasonable, we cannot guarantee that the future results, performance or events and circumstances described in the forward-looking statements will be achieved or occur. Recipients are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date such statements are made and should not be construed as statements of fact. We undertake no obligation to publicly update any forward-looking statements, whether as a result of new information, any future presentations or otherwise, except as required by applicable law. Certain information contained in these materials and any statements made orally during any presentation of these materials that relate to the materials or are based on studies, publications, surveys and other data obtained from third-party sources and our own internal estimates and research. While we believe these third-party studies, publications, surveys and other data to be reliable as of the date of these materials, we have not independently verified, and make no representations as to the adequacy, fairness, accuracy or completeness of, any information obtained from third-party sources. In addition, no independent source has evaluated the reasonableness or accuracy of our internal estimates or research and no reliance should be made on any information or statements made in these materials relating to or based on such internal estimates and research.

**Contacts:**

**Investors**<br>Shai Biran, Monte Rosa Therapeutics

ir@monterosatx.com

**Media**<br>Dan Budwick, 1AB<br>dan@1abmedia.com

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