# EDGAR Filing Document

**Accession Number:** 0001603466
**File Stem:** 0000899140-23-000367
**Filing Date:** 2023-2
**Character Count:** 14681
**Document Hash:** 99411169abd8ce4b80a96e582f55a42b
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000899140-23-000367.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0000899140-23-000367

**CONFORMED SUBMISSION TYPE**: SC 13G/A

**PUBLIC DOCUMENT COUNT**: 2

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**GROUP MEMBERS**: CUBIST SYSTEMATIC STRATEGIES, LLC

**GROUP MEMBERS**: POINT72 CAPITAL ADVISORS, INC.

**GROUP MEMBERS**: STEVEN A. COHEN

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Mereo Biopharma Group plc
- **CENTRAL INDEX KEY:** 0001719714
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** X0
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G/A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-91444
- **FILM NUMBER:** 23628616

**BUSINESS ADDRESS:**
- **STREET 1:** ONE CAVENDISH PLACE
- **STREET 2:** FOURTH FLOOR
- **CITY:** LONDON
- **STATE:** X0
- **ZIP:** W1G0QF
- **BUSINESS PHONE:** 4403330237300

**MAIL ADDRESS:**
- **STREET 1:** ONE CAVENDISH PLACE
- **STREET 2:** FOURTH FLOOR
- **CITY:** LONDON
- **STATE:** X0
- **ZIP:** W1G0QF
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Point72 Asset Management, L.P.
- **CENTRAL INDEX KEY:** 0001603466
- **IRS NUMBER:** 465064661
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G/A

**BUSINESS ADDRESS:**
- **STREET 1:** 72 CUMMINGS POINT ROAD
- **CITY:** STAMFORD
- **STATE:** CT
- **ZIP:** 06902
- **BUSINESS PHONE:** 203-890-2000

**MAIL ADDRESS:**
- **STREET 1:** 72 CUMMINGS POINT ROAD
- **CITY:** STAMFORD
- **STATE:** CT
- **ZIP:** 06902

#### 240.13d-102 Schedule 13G - Information to be included in statements filed

#### pursuant to 240.13d-1(b), (c), and (d) and amendments thereto

#### filed pursuant to 240.13d-2.
Securities and Exchange Commission, Washington, D.C. 20549

Schedule 13G

Under the Securities Exchange Act of 1934

(Amendment No. 2)\*

(Name of Issuer)

Mereo BioPharma Group plc

(Title of Class of Securities)

Ordinary shares, nominal value £0.003 per share¹

(CUSIP Number)

589492107²

(Date of Event Which Requires Filing of this Statement)

December 31, 2022

Check the appropriate box to designate the rule pursuant to which this

Schedule is filed:

[ ] Rule 13d-1(b)

[ x ] Rule 13d-1(c)

[ ] Rule 13d-1(d)

\*The remainder of this cover page shall be filled out for a reporting person's<br> initial filing on this form with respect to the subject class of securities, and<br> for any subsequent amendment containing information which would alter the<br> disclosures provided in a prior cover page.<br>The information required in the remainder of this cover page shall not be<br> deemed to be "filed" for the purpose of Section 18 of the Securities Exchange<br> Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the<br> Act but shall be subject to all other provisions of the Act (however, see<br> the Notes).<br>

1The holdings reported herein are held in the form of American Depositary Shares ("ADS"), which each represent five (5) ordinary shares, nominal value £0.003 per ordinary share of the Issuer ("Ordinary Shares").

2The CUSIP Number listed throughout this filing is the CUSIP assigned to the ADS of the Issuer.

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| | |
|:---|:---|
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; CUSIP No. 589492107 | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; CUSIP No. 589492107 |
| (1) Names of reporting persons Point72 Asset Management, L.P. |  |
| (2) Check the appropriate box if a member of a group | (a) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (see instructions) | (b)X |
| (3) SEC use only |  |
| (4) Citizenship or place of organization Delaware |  |
| Number of shares beneficially owned by each reporting person with: |  |
| (5) Sole voting power 0 |  |
| (6) Shared voting power 0 |  |
| (7) Sole dispositive power 0 |  |
| (8) Shared dispositive power 0 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (9) Aggregate amount beneficially owned by each reporting person<br> 0 |  |
| (10) Check if the aggregate amount in Row (9) excludes certain shares<br> (see instructions) |  |
| (11) Percent of class represented by amount in Row (9) 0% |  |
| (12) Type of reporting person (see instructions) PN |  |

---

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| | |
|:---|:---|
| CUSIP No. 589492107 | CUSIP No. 589492107 |
| (1) Names of reporting persons Point72 Capital Advisors, Inc. |  |
| (2) Check the appropriate box if a member of a group | (a) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (see instructions) | (b)X |
| (3) SEC use only |  |
| (4) Citizenship or place of organization Delaware |  |
| Number of shares beneficially owned by each reporting person with: |  |
| (5) Sole voting power 0 |  |
| (6) Shared voting power 0 |  |
| (7) Sole dispositive power 0 |  |
| (8) Shared dispositive power 0 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (9) Aggregate amount beneficially owned by each reporting person<br> 0 |  |
| (10) Check if the aggregate amount in Row (9) excludes certain shares<br> (see instructions) |  |
| (11) Percent of class represented by amount in Row (9) 0% |  |
| (12) Type of reporting person (see instructions) CO |  |

---

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| | |
|:---|:---|
| CUSIP No. 589492107 | CUSIP No. 589492107 |
| (1) Names of reporting persons Cubist Systematic Strategies, LLC |  |
| (2) Check the appropriate box if a member of a group | (a) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (see instructions) | (b)X |
| (3) SEC use only |  |
| (4) Citizenship or place of organization Delaware |  |
| Number of shares beneficially owned by each reporting person with: |  |
| (5) Sole voting power 0 |  |
| (6) Shared voting power 22\*\* |  |
| (7) Sole dispositive power 0 |  |
| (8) Shared dispositive power 22\*\* |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (9) Aggregate amount beneficially owned by each reporting person<br> 22\*\* |  |
| (10) Check if the aggregate amount in Row (9) excludes certain shares<br> (see instructions) |  |
| (11) Percent of class represented by amount in Row (9) <0.1% |  |
| (12) Type of reporting person (see instructions) OO |  |

---

<br>\*\*Consists of 22 American Depositary Shares, representing 110 Ordinary Shares.

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| | |
|:---|:---|
| CUSIP No. 589492107 | CUSIP No. 589492107 |
| (1) Names of reporting persons Steven A. Cohen |  |
| (2) Check the appropriate box if a member of a group | (a) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (see instructions) | (b)X |
| (3) SEC use only |  |
| (4) Citizenship or place of organization United States |  |
| Number of shares beneficially owned by each reporting person with: |  |
| (5) Sole voting power 0 |  |
| (6) Shared voting power 22\*\* |  |
| (7) Sole dispositive power 0 |  |
| (8) Shared dispositive power 22\*\* |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (9) Aggregate amount beneficially owned by each reporting person<br> 22\*\* |  |
| (10) Check if the aggregate amount in Row (9) excludes certain shares<br> (see instructions) |  |
| (11) Percent of class represented by amount in Row (9) <0.1% |  |
| (12) Type of reporting person (see instructions) IN |  |

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<br>\*\*Consists of 22 American Depositary Shares, representing 110 Ordinary Shares.

Item 1(a) Name of issuer:

Mereo BioPharma Group plc

Item 1(b) Address of issuer's principal executive offices:

4<sup>th</sup> Floor, One Cavendish Place, London W1G 0QF, United Kingdom

2(a) Name of person filing:

The holdings of the Issuer's ordinary shares, nominal value £0.003 per share ("Ordinary Shares")<br> reported herein are held in the form of American Depositary Shares ("ADS"), which each represent <br> five (5) Ordinary Shares. This statement is filed by: (i) Point72 Asset Management, L.P. ("Point72 <br> Asset Management") with respect to Ordinary Shares held, in the form of ADSs, by an investment <br> fund it manages; (ii) Point72 Capital Advisors, Inc. ("Point72 Capital Advisors Inc.") with respect <br> to Ordinary Shares held, in the form of ADSs, by an investment fund managed by Point72 Asset <br> Management; (iii) Cubist Systematic Strategies, LLC ("Cubist Systematic Strategies") with respect <br> to Ordinary Shares held, in the form of ADSs, by an investment fund it manages; and (iv) Steven <br> A. Cohen ("Mr. Cohen") with respect to Ordinary Shares held, in the form of ADSs, beneficially <br> owned by Point72 Asset Management, Point72 Capital Advisors Inc., and Cubist Systematic Strategies.

Point72 Asset Management, Point72 Capital Advisors Inc., Cubist Systematic Strategies, and <br> Mr. Cohen have entered into a Joint Filing Agreement, a copy of which is filed with this Schedule <br> 13G as Exhibit 99.1, pursuant to which they have agreed to file this Schedule 13G jointly in <br> accordance with the provisions of Rule 13d-1(k) of the Act.

2(b) Address or principal business office or, if none, residence:

The address of the principal business office of (i) Point72 Asset Management,<br> Point72 Capital Advisors Inc., and Mr. Cohen is 72 Cummings Point Road, Stamford, CT 06902; <br> and (ii) Cubist Systematic Strategies is 55 Hudson Yards, New York, NY 10001.

2(c) Citizenship:

Point72 Asset Management is a Delaware limited partnership. Point72 Capital Advisors Inc. is a <br> Delaware corporation. Cubist Systematic Strategies is a Delaware limited liability company. <br> Mr. Cohen is a United States citizen.

2(d) Title of class of securities:

Ordinary Shares, nominal value £0.003 per share

2(e) CUSIP Number:

589492107

*Item 3.*

Not applicable

*Item 4.* Ownership

The information required by Items 4(a) – (c) is set forth in Rows (5) – (11) of the cover page for each <br> Reporting Person hereto and is incorporated herein by reference for each Reporting Person. Such <br> information is as of the close of business on December 31, 2022.

Point72 Asset Management, Point72 Capital Advisors Inc., Cubist Systematic Strategies, <br> and Mr. Cohen own directly no ADSs or Ordinary Shares. Pursuant to an investment<br> management agreement, Point72 Asset Management maintains investment and voting<br>

power with respect to the securities held by an investment fund it manages. Point72 Capital <br> Advisors Inc. is the general partner of Point72 Asset Management. Pursuant to an investment <br> management agreement, Cubist Systematic Strategies maintains investment and voting power <br> with respect to the securities held by an investment fund it manages. Mr. Cohen controls<br> each of Point72 Asset Management, Point72 Capital Advisors Inc., and Cubist Systematic <br> Strategies. The filing of this statement should not be construed as an admission that any of the <br> foregoing persons or any reporting person is, for the purposes of Section 13 of the Act, the <br> beneficial owner of the Ordinary Shares reported herein.

*Item 5.* Ownership of 5 Percent or Less of a Class.

If this statement is being filed to report the fact that as of the date hereof the reporting person <br> has ceased to be the beneficial owner of more than 5 percent of the class of securities, check <br> the following [X].

*Item 6.* Ownership of More than 5 Percent on Behalf of Another Person.

See Item 2(a)

*Item 7.* Identification and Classification of the Subsidiary Which Acquired

the Security Being Reporting on by the Parent Holding Company or Control

Person.

Not applicable

*Item 8.* Identification and Classification of Members of the Group

Not applicable

*Item 9.* Notice of Dissolution of Group.

Not applicable

*Item 10.* Certifications

By signing below I certify that, to the best of my knowledge and belief, the securities <br> referred to above were not acquired and are not held for the purpose of or with the effect <br> of changing or influencing the control of the issuer of the securities and were not acquired <br> and are not held in connection with or as a participant in any transaction having that purpose <br> or effect.

*Signature.* After reasonable inquiry and to the best of my knowledge and belief,

I certify that the information set forth in this statement is true, complete

and correct.

Dated: <u>February 14, 2023</u>

POINT72 ASSET MANAGEMENT, L.P.

By: <u>/s/ Jason M. Colombo</u>

Name: Jason M. Colombo

Title: Authorized Person

POINT72 CAPITAL ADVISORS, INC.

By: <u>/s/ Jason M. Colombo</u>

Name: Jason M. Colombo

Title: Authorized Person

CUBIST SYSTEMATIC STRATEGIES, LLC

By: <u>/s/ Jason M. Colombo</u>

Name: Jason M. Colombo

Title: Authorized Person<br>

STEVEN A. COHEN

By: <u>/s/ Jason M. Colombo</u>

Name: Jason M. Colombo

Title: Authorized Person

## Exhibit 99.1

Exhibit 99.1

JOINT FILING AGREEMENT

The undersigned hereby agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, and that all subsequent amendments to this statement on Schedule 13G may be filed on behalf of each of the undersigned without the necessity of filing additional joint filing agreements.

Dated: <u>February 14, 2023</u>

POINT72 ASSET MANAGEMENT, L.P.

By: <u>/s/ Jason M. Colombo</u>

Name: Jason M. Colombo

Title: Authorized Person

POINT72 CAPITAL ADVISORS, INC.

By: <u>/s/ Jason M. Colombo</u>

Name: Jason M. Colombo

Title: Authorized Person

CUBIST SYSTEMATIC STRATEGIES, LLC

By: <u>/s/ Jason M. Colombo</u>

Name: Jason M. Colombo

Title: Authorized Person

STEVEN A. COHEN

By: <u>/s/ Jason M. Colombo</u>

Name: Jason M. Colombo

Title: Authorized Person