# EDGAR Filing Document

**Accession Number:** 0001039803
**File Stem:** 0000910472-25-001279
**Filing Date:** 2025-9
**Character Count:** 47889
**Document Hash:** 7c78dc621757caaf65080a3c238adf1d
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000910472-25-001279.hdr.sgml**: 20250926

**ACCESSION NUMBER**: 0000910472-25-001279

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20250731

**FILED AS OF DATE**: 20250926

**DATE AS OF CHANGE**: 20250926

**PERIOD START**: 20250731

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** ProFunds
- **CENTRAL INDEX KEY:** 0001039803

**ORGANIZATION NAME:**
- **EIN:** 522035197
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-08239
- **FILM NUMBER:** 251346468

**BUSINESS ADDRESS:**
- **STREET 1:** 7272 WISCONSIN AVENUE
- **STREET 2:** 21ST FLOOR
- **CITY:** BETHESDA
- **STATE:** MD
- **ZIP:** 20814
- **BUSINESS PHONE:** 2404976428

**MAIL ADDRESS:**
- **STREET 1:** 7272 WISCONSIN AVENUE
- **STREET 2:** 21ST FLOOR
- **CITY:** BETHESDA
- **STATE:** MD
- **ZIP:** 20814

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** PROFUNDS
- **DATE OF NAME CHANGE:** 19970521

## Series and Classes Contracts Data

### BIOTECHNOLOGY ULTRASECTOR PROFUND (Series ID: S000003107)

| Class ID   | Class Name                                       | Ticker Symbol   |
|:---|:---|:---|
| C000008429 | BIOTECHNOLOGY ULTRASECTOR PROFUND INVESTOR CLASS | BIPIX           |
| C000008430 | BIOTECHNOLOGY ULTRASECTOR PROFUND SERVICE CLASS  | BIPSX           |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** ProFunds

- **b. Investment Company Act file number:** 811-08239

- **c. CIK number of Registrant:** 0001039803

- **d. LEI of Registrant:** 549300HM4OOUYSE5DP77

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 7272 Wisconsin Avenue

  - **City:** Bethesda

  - **State:** MD

  - **Foreign country:** US

  - **Zip / Postal Code:** 20814

  - **Telephone number:** 240-497-6400

**Item A.2. Information about the Series.**

- **a. Name of Series:** BIOTECHNOLOGY ULTRASECTOR PROFUND

- **b. EDGAR series identifier (if any):** S000003107

- **c. LEI of Series:** ZWFZRAZNVXWXUXSEEF10

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2025-07-31

- **b. Date as of which information is reported:** 2025-07-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $113390271.47

**Total Liabilities:** $50616299.78

**Net Assets:** $62773971.69

**Cash Not Reported:** $1149.54

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000008430 | -7.59%               | 6.57%                | 4.38%                |
| Class ID C000008429 | -7.52%               | 6.67%                | 4.47%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $23.88                   | $-2305246.22                               |
| Month 2  | $-346889.19              | $2576332.12                                |
| Month 3  | $743230.93               | $907821.08                                 |

**Designated Index Information**

- **Index Name:** Dow Jones U.S. Biotechnology Index

- **Index Identifier:** DJUSBT

### Schedule of Portfolio Investments

| Name                                | Title                                         | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Exelixis, Inc.                      | Exelixis, Inc.                                | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |     29332 | NS      | $1062405.04   | 1.69%             |  |  |  | No            |                  1 | On Loan: No      |
| Revolution Medicines Inc            | REVOLUTION Medicines Inc                      | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |     19338 | NS      | $720727.26    | 1.15%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                 | BIPIX_SPSIBI_GOLDMAN                          | CUSIP: N/A<br>LEI: N/A                        | Long             | DE               |  | US        |      3520 | OU      | $-747069.19   | -1.19%            |  |  |  | No            |                  2 | On Loan: No      |
| Incyte Corporation.                 | Incyte Corp.                                  | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |     17650 | NS      | $1321808.50   | 2.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Dianthus Therapeutics Inc           | Dianthus Therapeutics Inc                     | CUSIP: 252828108<br>LEI: 549300Z3N6ODPCOFC890 | Long             | EC               | CORP              | US        |      3605 | NS      | $74515.35     | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcutis Biotherapeutics Inc.        | Arcutis Biotherapeutics                       | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     19512 | NS      | $284484.96    | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                 | UMB FINANCIAL CORP.  4.09 , 8/01/2025         | CUSIP: N/A<br>LEI: N/A                        | Long             | RA               | CORP              | US        |   2650000 | PA      | $2650000.00   | 4.22%             |  |  |  | No            |                  2 | On Loan: No      |
| PTC Therapeutics, Inc.              | PTC Therapeutics, Inc.                        | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |     12342 | NS      | $643141.62    | 1.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Rigel Pharmaceuticals Inc.          | Rigel Pharmaceuticals Inc                     | CUSIP: 766559702<br>LEI: 529900KPTNUS5J8K9K66 | Long             | EC               | CORP              | US        |      2313 | NS      | $48711.78     | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals Incorporated | Vertex Pharmaceuticals, Inc.                  | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |      2686 | NS      | $1227152.82   | 1.95%             |  |  |  | No            |                  1 | On Loan: No      |
| Keros Therapeutics Inc.             | Keros Therapeutics Inc                        | CUSIP: 492327101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6863 | NS      | $98278.16     | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Insmed Inc                          | Insmed, Inc.                                  | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |     12403 | NS      | $1330593.84   | 2.12%             |  |  |  | No            |                  1 | On Loan: No      |
| BioCryst Pharmaceuticals  Inc.      | BIOCRYST PHARMACEUTICALS, INC.                | CUSIP: 09058V103<br>LEI: 549300Z0INP1Z5NP6J59 | Long             | EC               | CORP              | US        |     38045 | NS      | $309686.30    | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Viking Therapeutics Inc.            | Viking Therapeutics, Inc.                     | CUSIP: 92686J106<br>LEI: 529900IVC72YPFA25M37 | Long             | EC               | CORP              | US        |     19910 | NS      | $648468.70    | 1.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Vericel Corporation                 | Vericel Corp.                                 | CUSIP: 92346J108<br>LEI: 54930076YM3PLTDR4B91 | Long             | EC               | CORP              | US        |      6003 | NS      | $209744.82    | 0.33%             |  |  |  | No            |                  1 | On Loan: No      |
| Veracyte Inc                        | Veracyte, Inc.                                | CUSIP: 92337F107<br>LEI: 529900ESWZRHXOW27Z37 | Long             | EC               | CORP              | US        |     13757 | NS      | $323427.07    | 0.52%             |  |  |  | No            |                  1 | On Loan: No      |
| Amicus Therapeutics Inc.            | Amicus Therapeutic, Inc.                      | CUSIP: 03152W109<br>LEI: 549300MRD1SMUTNBPQ53 | Long             | EC               | CORP              | US        |     52467 | NS      | $314277.33    | 0.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Verastem Inc                        | Verastem Inc                                  | CUSIP: 92337C203<br>LEI: 549300IY0EFBIU8NQC81 | Long             | EC               | CORP              | US        |     13255 | NS      | $81783.35     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Janux Therapeutics Inc              | Janux Therapeutics Inc                        | CUSIP: 47103J105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5932 | NS      | $142456.98    | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                 | NATWEST MARKETS PLC  4.22 , 8/01/2025         | CUSIP: N/A<br>LEI: N/A                        | Long             | RA               | CORP              | US        |   1609000 | PA      | $1609000.00   | 2.56%             |  |  |  | No            |                  2 | On Loan: No      |
| Soleno Therapeutics Inc             | Soleno Therapeutics Inc                       | CUSIP: 834203309<br>LEI: 5493003LCY77N7FXK844 | Long             | EC               | CORP              | US        |      5992 | NS      | $518128.24    | 0.83%             |  |  |  | No            |                  1 | On Loan: No      |
| Halozyme Therapeutics Inc           | Halozyme Therapeutics, Inc.                   | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |     22567 | NS      | $1353342.99   | 2.16%             |  |  |  | No            |                  1 | On Loan: No      |
| GRAIL Inc                           | GRAIL, Inc.                                   | CUSIP: 384747101<br>LEI: 2549009XSNESW3VE8024 | Long             | EC               | CORP              | US        |      5187 | NS      | $177447.27    | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Apellis Pharmaceuticals Inc         | Apellis Pharmaceuticals, Inc.                 | CUSIP: 03753U106<br>LEI: 254900HS0ZFRXXSB9D42 | Long             | EC               | CORP              | US        |     18185 | NS      | $406252.90    | 0.65%             |  |  |  | No            |                  1 | On Loan: No      |
| Mannkind Corporation                | Mannkind Corp.                                | CUSIP: 56400P706<br>LEI: 213800GFBCNY1ZFST722 | Long             | EC               | CORP              | US        |     29745 | NS      | $112436.10    | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                 | CREDIT AGRICOLE CIB NY  4.23 , 8/01/2025      | CUSIP: N/A<br>LEI: N/A                        | Long             | RA               | CORP              | US        |   1609000 | PA      | $1609000.00   | 2.56%             |  |  |  | No            |                  2 | On Loan: No      |
| Exact Sciences Corporation          | Exact Sciences Corp.                          | CUSIP: 30063P105<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |     21833 | NS      | $1025059.35   | 1.63%             |  |  |  | No            |                  1 | On Loan: No      |
| Twist Bioscience Corporation        | Twist Bioscience Corp.                        | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |      9564 | NS      | $321063.48    | 0.51%             |  |  |  | No            |                  1 | On Loan: No      |
| Immunome Inc                        | Immunome Inc                                  | CUSIP: 45257U108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      9658 | NS      | $101602.16    | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Apogee Therapeutics Inc.            | Apogee Therapeutics Inc                       | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5336 | NS      | $204155.36    | 0.33%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                 | ROYAL BANK OF CANADA  4.14 , 8/01/2025        | CUSIP: N/A<br>LEI: N/A                        | Long             | RA               | CORP              | US        |    964000 | PA      | $964000.00    | 1.54%             |  |  |  | No            |                  2 | On Loan: No      |
| ORIC Pharmaceuticals Inc.           | ORIC Pharmaceuticals Inc                      | CUSIP: 68622P109<br>LEI: 54930033FJRNEYBW0L25 | Long             | EC               | CORP              | US        |      5391 | NS      | $53748.27     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| CG Oncology Inc.                    | CG oncology Inc                               | CUSIP: 156944100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     10142 | NS      | $270689.98    | 0.43%             |  |  |  | No            |                  1 | On Loan: No      |
| Iovance Biotherapeutics Inc         | Iovance Biotheraputics, Inc.                  | CUSIP: 462260100<br>LEI: 2549002L8WT2ACU5Q878 | Long             | EC               | CORP              | US        |     36970 | NS      | $95012.90     | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Day One Biopharmaceuticals Inc.     | Day One Biopharmaceuticals Inc                | CUSIP: 23954D109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     12476 | NS      | $83713.96     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Arbutus Biopharma Corp.             | Arbutus Biopharma Corp                        | CUSIP: 03879J100<br>LEI: 25490064CESONAUIAS23 | Long             | EC               | CORP              | CA        |     11182 | NS      | $36676.96     | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Acadia Pharmaceuticals Inc          | ACADIA Pharmaceuticals, Inc.                  | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |     15895 | NS      | $378777.85    | 0.60%             |  |  |  | No            |                  1 | On Loan: No      |
| Kymera Therapeutics Inc             | Kymera Therapeutics, Inc.                     | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      5074 | NS      | $221987.50    | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| CRISPR Therapeutics AG              | CRISPR Therapeutics AG                        | CUSIP: H17182108<br>LEI: 506700O6IRRIQLT3W370 | Long             | EC               | CORP              | CH        |     14455 | NS      | $813238.30    | 1.30%             |  |  |  | No            |                  1 | On Loan: —       |
| Madrigal Pharmaceuticals Inc        | Madrigal Pharmaceuticals, Inc.                | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |      3101 | NS      | $938083.51    | 1.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Cullinan Therapeutics Inc           | Cullinan Oncology Inc                         | CUSIP: 230031106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4958 | NS      | $38523.66     | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Adma Biologics Inc                  | ADMA Biologics, Inc.                          | CUSIP: 000899104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     33617 | NS      | $628637.90    | 1.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Summit Therapeutics Inc.            | Summit Therapeutics Inc                       | CUSIP: 86627T108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     25138 | NS      | $662889.06    | 1.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Kura Oncology Inc.                  | KURA ONCOLOGY, INC.                           | CUSIP: 50127T109<br>LEI: 5493005QORQTZCZYOP39 | Long             | EC               | CORP              | US        |     13288 | NS      | $80392.40     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Catalyst Pharmaceuticals Inc.       | Catalyst Pharmaceuticals, Inc.                | CUSIP: 14888U101<br>LEI: 5299004O0R5XXLA5H544 | Long             | EC               | CORP              | US        |     12100 | NS      | $258093.00    | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Beam Therapeutics Inc.              | Beam Therapeutics, Inc.                       | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     15528 | NS      | $306056.88    | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Disc Medicine Inc                   | Disc Medicine Inc                             | CUSIP: 254604101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3981 | NS      | $237904.56    | 0.38%             |  |  |  | No            |                  1 | On Loan: No      |
| Celldex Therapeutics Inc.           | Celldex Therapeutics, Inc.                    | CUSIP: 15117B202<br>LEI: 529900F018DMYWH38923 | Long             | EC               | CORP              | US        |      9046 | NS      | $198831.08    | 0.32%             |  |  |  | No            |                  1 | On Loan: No      |
| Ionis Pharmaceuticals, Inc.         | Ionis Pharmaceuticals, Inc.                   | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |     18301 | NS      | $786576.98    | 1.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcus Biosciences Inc.              | Arcus Biosciences, Inc.                       | CUSIP: 03969F109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     12476 | NS      | $113905.88    | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| IDEAYA Biosciences Inc.             | Ideaya Biosciences Inc                        | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |     13881 | NS      | $338002.35    | 0.54%             |  |  |  | No            |                  1 | On Loan: No      |
| Alkermes PLC                        | Alkermes PLC                                  | CUSIP: G01767105<br>LEI: N/A                  | Long             | EC               | CORP              | IE        |     20389 | NS      | $540104.61    | 0.86%             |  |  |  | No            |                  1 | On Loan: No      |
| Arrowhead Pharmaceuticals Inc       | Arrowhead Pharmaceuticals, Inc.               | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |     17941 | NS      | $283467.80    | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| KalVista Pharmaceuticals Inc.       | KalVista Pharmaceuticals, Inc.                | CUSIP: 483497103<br>LEI: 529900Q7IDA3WUGRZA51 | Long             | EC               | CORP              | US        |      5929 | NS      | $80812.27     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Avidity Biosciences Inc.            | Avidity Biosciences, Inc.                     | CUSIP: 05370A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     16040 | NS      | $588828.40    | 0.94%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcturus Therapeutics Holdings Inc  | Arcturus Therapeutics Holdings Inc            | CUSIP: 03969T109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      4759 | NS      | $58107.39     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                 | BIPIX_SPSIBI_UB                               | CUSIP: N/A<br>LEI: N/A                        | Short            | DE               |  | US        |       -68 | OU      | $-54.44       | -0.00%            |  |  |  | No            |                  2 | On Loan: No      |
| Taysha Gene Therapies Inc.          | Taysha Gene Therapies Inc                     | CUSIP: 877619106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     15003 | NS      | $40958.19     | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Metsera Inc.                        | Metsera, Inc.                                 | CUSIP: 59267L107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      2439 | NS      | $80462.61     | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Anavex Life Sciences Corp.          | ANAVEX LIFE SCIENCES CORPORATION              | CUSIP: 032797300<br>LEI: 549300K1I5L8COCQ8W36 | Long             | EC               | CORP              | US        |     11649 | NS      | $131633.70    | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Regeneron Pharmaceuticals, Inc.     | Regeneron Pharmaceuticals, Inc.               | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |      2343 | NS      | $1278012.78   | 2.04%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                 | SOCIETE' GENERALE  4.22 , 8/01/2025           | CUSIP: N/A<br>LEI: N/A                        | Long             | RA               | CORP              | US        |   3863000 | PA      | $3863000.00   | 6.15%             |  |  |  | No            |                  2 | On Loan: No      |
| Nuvalent Inc                        | Nuvalent Inc.                                 | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      6116 | NS      | $479188.60    | 0.76%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals Inc.        | Alnylam Pharmaceuticals, Inc.                 | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |      4070 | NS      | $1596416.80   | 2.54%             |  |  |  | No            |                  1 | On Loan: No      |
| Stoke Therapeutics Inc              | Stoke Therapeutics Inc                        | CUSIP: 86150R107<br>LEI: 549300RD25SS2DIJHJ67 | Long             | EC               | CORP              | US        |      6505 | NS      | $83589.25     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| AbbVie Inc.                         | AbbVie, Inc.                                  | CUSIP: 00287Y109<br>LEI: FR5LCKFTG8054YNNRU85 | Long             | EC               | CORP              | US        |      6346 | NS      | $1199520.92   | 1.91%             |  |  |  | No            |                  1 | On Loan: No      |
| Uniqure N.V.                        | uniQure NV                                    | CUSIP: N90064101<br>LEI: 724500RPCTZLFYJZ3S98 | Long             | EC               | CORP              | NL        |      8698 | NS      | $121076.16    | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Cogent Biosciences Inc.             | Cogent Biosciences, Inc.                      | CUSIP: 19240Q201<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     11587 | NS      | $132323.54    | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Biohaven Ltd                        | Biohaven Ltd.                                 | CUSIP: G1110E107<br>LEI: N/A                  | Long             | EC               | CORP              | VG        |     15320 | NS      | $231332.00    | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Nurix Therapeutics Inc.             | Nurix Therapeutics Inc                        | CUSIP: 67080M103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      9573 | NS      | $107791.98    | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Xencor Inc                          | XENCOR, INC.                                  | CUSIP: 98401F105<br>LEI: 549300V5IF65437JKG30 | Long             | EC               | CORP              | US        |     11453 | NS      | $95288.96     | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences Inc          | Neurocrine Biosciences Inc.                   | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |      9787 | NS      | $1254987.01   | 2.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Travere Therapeutics Inc            | Travere Therapeutics, Inc.                    | CUSIP: 89422G107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     15657 | NS      | $241900.65    | 0.39%             |  |  |  | No            |                  1 | On Loan: No      |
| United Therapeutics Corporation     | United Therapeutics Corp.                     | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |      4395 | NS      | $1207306.50   | 1.92%             |  |  |  | No            |                  1 | On Loan: No      |
| Spyre Therapeutics Inc              | Spyre Therapeutics Inc                        | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |      6442 | NS      | $109320.74    | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Relay Therapeutics Inc              | Relay Therapeutics Inc                        | CUSIP: 75943R102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     23002 | NS      | $80967.04     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| MiMedx Group Inc.                   | MiMedx Group, Inc.                            | CUSIP: 602496101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7961 | NS      | $57239.59     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| 89bio Inc.                          | 89Bio, Inc.                                   | CUSIP: 282559103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     15467 | NS      | $146936.50    | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Crinetics Pharmaceuticals Inc.      | Crinetics Pharmaceuticals Inc                 | CUSIP: 22663K107<br>LEI: 549300Q1CNFXK5P31D28 | Long             | EC               | CORP              | US        |     11473 | NS      | $328013.07    | 0.52%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                 | BIPIX_SPSIBI_GOLDMAN                          | CUSIP: N/A<br>LEI: N/A                        | Short            | DE               |  | US        |      -311 | OU      | $25915.99     | 0.04%             |  |  |  | No            |                  2 | On Loan: No      |
| Syndax Pharmaceuticals Inc.         | Syndax Pharmaceuticals                        | CUSIP: 87164F105<br>LEI: 529900OF94TRHKZVBS87 | Long             | EC               | CORP              | US        |     15934 | NS      | $158065.28    | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Geron Corp.                         | Geron Corp                                    | CUSIP: 374163103<br>LEI: 549300T282D7Z2YESL90 | Long             | EC               | CORP              | US        |    104736 | NS      | $120446.40    | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Dyne Therapeutics Inc.              | Dyne Therapeutics Inc                         | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     13937 | NS      | $137279.45    | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Emergent Biosolutions Inc           | Emergent BioSolutions, Inc.                   | CUSIP: 29089Q105<br>LEI: 549300YW6TUOX8BE5103 | Long             | EC               | CORP              | US        |      9849 | NS      | $57912.12     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Akero Therapeutics Inc              | Akero Therapeutics, Inc.                      | CUSIP: 00973Y108<br>LEI: 549300SI3KG74LBE2955 | Long             | EC               | CORP              | US        |     11773 | NS      | $575111.05    | 0.92%             |  |  |  | No            |                  1 | On Loan: No      |
| Immunovant Inc                      | Immunovant, Inc.                              | CUSIP: 45258J102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     13459 | NS      | $216420.72    | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Caredx Inc                          | CareDx, Inc.                                  | CUSIP: 14167L103<br>LEI: 549300NQOFKL9NON0U06 | Long             | EC               | CORP              | US        |      9022 | NS      | $110835.27    | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| AnaptysBio Inc.                     | AnaptysBio Inc                                | CUSIP: 032724106<br>LEI: 529900HH4WQT03IG1A12 | Long             | EC               | CORP              | US        |      3392 | NS      | $83273.60     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| ArriVent BioPharma Inc.             | ArriVent Biopharma Inc                        | CUSIP: 04272N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      1991 | NS      | $38844.41     | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Praxis Precision Medicines Inc      | Praxis Precision Medicines Inc                | CUSIP: 74006W207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      3136 | NS      | $170033.92    | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                 | HSBC SECURITIES (USA), INC.  4.25 , 8/01/2025 | CUSIP: N/A<br>LEI: N/A                        | Long             | RA               | CORP              | US        |   3863000 | PA      | $3863000.00   | 6.15%             |  |  |  | No            |                  2 | On Loan: No      |
| Replimune Group Inc                 | Replimune Group Inc                           | CUSIP: 76029N106<br>LEI: 549300AY704NEIRC4K64 | Long             | EC               | CORP              | US        |     10054 | NS      | $70679.62     | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Agios Pharmaceuticals Inc           | Agios Pharmaceuticals, Inc.                   | CUSIP: 00847X104<br>LEI: 529900ONJHY8EOGYT555 | Long             | EC               | CORP              | US        |      6245 | NS      | $232438.90    | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Recursion Pharmaceuticals Inc       | Recursion Pharmaceuticals Inc                 | CUSIP: 75629V104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     45025 | NS      | $267898.75    | 0.43%             |  |  |  | No            |                  1 | On Loan: —       |
| Novavax Inc                         | Novavax, Inc.                                 | CUSIP: 670002401<br>LEI: 529900J4GJHPEPQ23205 | Long             | EC               | CORP              | US        |     32111 | NS      | $213538.15    | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Ardelyx Inc                         | Ardelyx, Inc.                                 | CUSIP: 039697107<br>LEI: 549300F542QR4SXHCY32 | Long             | EC               | CORP              | US        |     45446 | NS      | $192691.04    | 0.31%             |  |  |  | No            |                  1 | On Loan: No      |
| Vera Therapeutics Inc.              | Vera Therapeutics Inc                         | CUSIP: 92337R101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      9111 | NS      | $189417.69    | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Krystal Biotech Inc                 | Krystal Biotech, Inc.                         | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |      4382 | NS      | $674258.34    | 1.07%             |  |  |  | No            |                  1 | On Loan: No      |
| AGPXX                               | Invesco Government & Agency Portfolio         | CUSIP: 825252885<br>LEI: N/A                  | Long             | STIV             | RF                | US        |   1773710 | NS      | $1773709.50   | 2.83%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen Inc                          | Biogen, Inc.                                  | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |      9133 | NS      | $1169024.00   | 1.86%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                 | Eli Lilly & Company                           | CUSIP: N/A<br>LEI: N/A                        | Long             |  | CORP              | US        |      9511 | NS      | $5991.93      | 0.01%             |  |  |  | No            |                  3 | On Loan: No      |
| VIR Biotechnology Inc               | Vir Biotechnology Inc                         | CUSIP: 92764N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     16689 | NS      | $84613.23     | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Intellia Therapeutics Inc           | Intellia Therapeutics, Inc.                   | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |     16281 | NS      | $189510.84    | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| ARS Pharmaceuticals Inc             | ARS Pharmaceuticals Inc                       | CUSIP: 82835W108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     10220 | NS      | $180689.60    | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Mirum Pharmaceuticals Inc.          | Mirum Pharmaceuticals, Inc.                   | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |      4703 | NS      | $243051.04    | 0.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Moderna Inc                         | Moderna, Inc.                                 | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |     43792 | NS      | $1294491.52   | 2.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Protagonist Therapeutics Inc        | Protagonist Therapeutics Inc                  | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     10182 | NS      | $548402.52    | 0.87%             |  |  |  | No            |                  1 | On Loan: No      |
| Viridian Therapeutics Inc           | Viridian Therapeutics Inc                     | CUSIP: 92790C104<br>LEI: 549300C775BNYF550E70 | Long             | EC               | CORP              | US        |      9660 | NS      | $169243.20    | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| Dynavax Technologies Corp.          | DYNAVAX TECHNOLOGIES CORPORATION              | CUSIP: 268158201<br>LEI: 549300T5URIXWDILX594 | Long             | EC               | CORP              | US        |     20567 | NS      | $225825.66    | 0.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytokinetics Inc                    | Cytokinetics, Inc.                            | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |     21427 | NS      | $806512.28    | 1.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Humacyte Inc.                       | Humacyte, Inc.                                | CUSIP: 44486Q103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     23419 | NS      | $56205.60     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Roivant Sciences Ltd                | Roivant Sciences Ltd.                         | CUSIP: G76279101<br>LEI: 549300DL466NY5J6U724 | Long             | EC               | CORP              | BM        |     74696 | NS      | $848546.56    | 1.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Mineralys Therapeutics Inc.         | Mineralys Therapeutics, Inc.                  | CUSIP: 603170101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7253 | NS      | $102629.95    | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| TG Therapeutics Inc                 | TG Therapeutics, Inc.                         | CUSIP: 88322Q108<br>LEI: 529900X21UKABN9NJ529 | Long             | EC               | CORP              | US        |     23794 | NS      | $844687.00    | 1.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Akebia Therapeutics Inc.            | AKEBIA THERAPEUTICS, INC.                     | CUSIP: 00972D105<br>LEI: 549300CBQEHMKEEGNX42 | Long             | EC               | CORP              | US        |     32104 | NS      | $118303.24    | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Myriad Genetics Inc.                | Myriad Genetics, Inc.                         | CUSIP: 62855J104<br>LEI: 52990044IHUOUMETT163 | Long             | EC               | CORP              | US        |     14278 | NS      | $54827.52     | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Capricor Therapeutics Inc           | Capricor Therapeutics Inc                     | CUSIP: 14070B309<br>LEI: 5493002ZI5PDLXV4DX14 | Long             | EC               | CORP              | US        |      6061 | NS      | $49578.98     | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Regenxbio Inc.                      | REGENXBIO INC.                                | CUSIP: 75901B107<br>LEI: 549300EOES47LATSET33 | Long             | EC               | CORP              | US        |      7668 | NS      | $65254.68     | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Ultragenyx Pharmaceuticals Inc      | Ultragenyx Pharmaceutical, Inc.               | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |     10252 | NS      | $280084.64    | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Bridgebio Pharma Inc                | Bridgebio Pharma, Inc.                        | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |     24876 | NS      | $1175888.52   | 1.87%             |  |  |  | No            |                  1 | On Loan: No      |
| Scholar Rock Holding Corp.          | Scholar Rock Holding Corp                     | CUSIP: 80706P103<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |     12623 | NS      | $467682.15    | 0.75%             |  |  |  | No            |                  1 | On Loan: No      |
| Altimmune Inc.                      | Altimmune Inc                                 | CUSIP: 02155H200<br>LEI: 549300EOYCQ8SW3NVE64 | Long             | EC               | CORP              | US        |     12896 | NS      | $47586.24     | 0.08%             |  |  |  | No            |                  1 | On Loan: —       |
| Vaxcyte Inc                         | Vaxcyte, Inc.                                 | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |     20836 | NS      | $707382.20    | 1.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Denali Therapeutics Inc             | Denali Therapeutics, Inc.                     | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |     15456 | NS      | $213756.48    | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Gilead Sciences Inc.                | Gilead Sciences, Inc.                         | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |     11118 | NS      | $1248440.22   | 1.99%             |  |  |  | No            |                  1 | On Loan: No      |
| ImmunityBio Inc                     | ImmunityBio Inc                               | CUSIP: 45256X103<br>LEI: 529900J9XLBR4HFL4B83 | Long             | EC               | CORP              | US        |     31916 | NS      | $78513.36     | 0.13%             |  |  |  | No            |                  1 | On Loan: —       |
| Arcellx Inc                         | Arcellx, Inc.                                 | CUSIP: 03940C100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7126 | NS      | $508725.14    | 0.81%             |  |  |  | No            |                  1 | On Loan: No      |
| Natera Inc.                         | Natera, Inc.                                  | CUSIP: 632307104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      7287 | NS      | $973980.42    | 1.55%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                 | BIPIX_SPSIBI_UB                               | CUSIP: N/A<br>LEI: N/A                        | Long             | DE               |  | US        |      3459 | OU      | $-738669.77   | -1.18%            |  |  |  | No            |                  2 | On Loan: No      |
| Sarepta Therapeutics Inc            | Sarepta Therapeutics, Inc.                    | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |     18715 | NS      | $307300.30    | 0.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Biomarin Pharmaceutical Inc.        | BioMarin Pharmaceutical, Inc.                 | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |     21260 | NS      | $1229891.00   | 1.96%             |  |  |  | No            |                  1 | On Loan: No      |
| Rhythm Pharmaceuticals Inc          | Rhythm Pharmaceuticals Inc                    | CUSIP: 76243J105<br>LEI: 529900JPNWXQ8DPLA551 | Long             | EC               | CORP              | US        |      6524 | NS      | $556040.52    | 0.89%             |  |  |  | No            |                  1 | On Loan: No      |
| Amgen Inc.                          | Amgen, Inc.                                   | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |      4164 | NS      | $1228796.40   | 1.96%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2025-07-31

**Name of Applicant:** Biotechnology UltraSector ProFund

**Signature:** Rebecca Colvin

**Name of Signer:** Rebecca Colvin

**Title:** Treasurer and Principal Financial Officer