# EDGAR Filing Document

**Accession Number:** 0001100663
**File Stem:** 0001410368-25-010175
**Filing Date:** 2025-9
**Character Count:** 20226
**Document Hash:** 32bef1597c96b33e63fcaf6312128613
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001410368-25-010175.hdr.sgml**: 20250924

**ACCESSION NUMBER**: 0001410368-25-010175

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20250731

**FILED AS OF DATE**: 20250924

**DATE AS OF CHANGE**: 20250924

**PERIOD START**: 20250731

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** iSHARES TRUST
- **CENTRAL INDEX KEY:** 0001100663

**ORGANIZATION NAME:**
- **EIN:** 943351276
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-09729
- **FILM NUMBER:** 251338648

**BUSINESS ADDRESS:**
- **STREET 1:** 400 HOWARD STREET
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94105
- **BUSINESS PHONE:** (415) 670-2000

**MAIL ADDRESS:**
- **STREET 1:** 400 HOWARD STREET
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94105

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ISHARES TRUST
- **DATE OF NAME CHANGE:** 19991213

## Series and Classes Contracts Data

### iShares Genomics Immunology and Healthcare ETF (Series ID: S000065599)

| Class ID   | Class Name                                     | Ticker Symbol   |
|:---|:---|:---|
| C000212225 | iShares Genomics Immunology and Healthcare ETF | IDNA            |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** iShares Trust

- **b. Investment Company Act file number:** 811-09729

- **c. CIK number of Registrant:** 0001100663

- **d. LEI of Registrant:** 5493000860OXIC4B5K91

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 400 Howard Street

  - **City:** San Francisco

  - **State:** CA

  - **Foreign country:** US

  - **Zip / Postal Code:** 94105

  - **Telephone number:** 800-474-2737

**Item A.2. Information about the Series.**

- **a. Name of Series:** iShares Genomics Immunology and Healthcare ETF

- **b. EDGAR series identifier (if any):** S000065599

- **c. LEI of Series:** 549300KS9JS2Z81CYC21

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2025-07-31

- **b. Date as of which information is reported:** 2025-07-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $141756802.95

**Total Liabilities:** $32653110.59

**Net Assets:** $109103692.36

**Cash Not Reported:** $90064.10

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000212225 | -4.08%               | 2.32%                | 3.10%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $5545.11                 | $-4830872.83                               |
| Month 2  | $-3258085.63             | $5755747.82                                |
| Month 3  | $2320003.90              | $991473.24                                 |

### Schedule of Portfolio Investments

| Name                                           | Title                                                 | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Ligand Pharmaceuticals Inc                     | Ligand Pharmaceuticals Inc                            | CUSIP: 53220K504<br>LEI: 5493008K7TB0IKP37H79 | Long             | EC               | CORP              | US        |      1877 | NS      | $246975.66    | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Rigel Pharmaceuticals Inc                      | Rigel Pharmaceuticals Inc                             | CUSIP: 766559702<br>LEI: 529900KPTNUS5J8K9K66 | Long             | EC               | CORP              | US        |     44573 | NS      | $938707.38    | 0.86%             |  |  |  | No            |                  1 | On Loan: —       |
| BioNTech SE                                    | BioNTech SE                                           | CUSIP: 09075V102<br>LEI: 894500UZJ5LG1F8J1U58 | Long             | EC               | CORP              | DE        |     41861 | NS      | $4500057.50   | 4.12%             |  |  |  | No            |                  1 | On Loan: —       |
| Kura Oncology Inc                              | Kura Oncology Inc                                     | CUSIP: 50127T109<br>LEI: 5493005QORQTZCZYOP39 | Long             | EC               | CORP              | US        |    211086 | NS      | $1277070.30   | 1.17%             |  |  |  | No            |                  1 | On Loan: —       |
| BioCryst Pharmaceuticals Inc                   | BioCryst Pharmaceuticals Inc                          | CUSIP: 09058V103<br>LEI: 549300Z0INP1Z5NP6J59 | Long             | EC               | CORP              | US        |    411366 | NS      | $3348519.24   | 3.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Mereo Biopharma Group PLC                      | Mereo Biopharma Group PLC                             | CUSIP: 589492107<br>LEI: 213800U8JQHIJOS5AS09 | Long             | EC               | CORP              | GB        |    369042 | NS      | $623680.98    | 0.57%             |  |  |  | No            |                  1 | On Loan: —       |
| Immunome Inc                                   | Immunome Inc                                          | CUSIP: 45257U108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    197032 | NS      | $2072776.64   | 1.90%             |  |  |  | No            |                  1 | On Loan: —       |
| AbCellera Biologics Inc                        | AbCellera Biologics Inc                               | CUSIP: 00288U106<br>LEI: 9845000861BC95FF9F73 | Long             | EC               | CORP              | CA        |    574532 | NS      | $2568158.04   | 2.35%             |  |  |  | No            |                  1 | On Loan: —       |
| Pacific Biosciences of California Inc          | Pacific Biosciences of California Inc                 | CUSIP: 69404D108<br>LEI: 529900F1BWRE1M0KZN89 | Long             | EC               | CORP              | US        |    677667 | NS      | $935180.46    | 0.86%             |  |  |  | No            |                  1 | On Loan: —       |
| Valneva SE                                     | Valneva SE                                            | CUSIP: 000000000<br>LEI: 969500DIVIP5VKNW4948 | Long             | EC               | CORP              | FR        |    365413 | NS      | $1346270.16   | 1.23%             |  |  |  | No            |                  2 | On Loan: —       |
| Geron Corp                                     | Geron Corp                                            | CUSIP: 374163103<br>LEI: 549300T282D7Z2YESL90 | Long             | EC               | CORP              | US        |   1547969 | NS      | $1780164.35   | 1.63%             |  |  |  | No            |                  1 | On Loan: No      |
| OMNIAB INC                                     | OMNIAB INC                                            | CUSIP: 68218J301<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     19498 | NS      | $0.19         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Beam Therapeutics Inc                          | Beam Therapeutics Inc                                 | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      8987 | NS      | $177133.77    | 0.16%             |  |  |  | No            |                  1 | On Loan: —       |
| Ginkgo Bioworks Holdings Inc                   | Ginkgo Bioworks Holdings Inc                          | CUSIP: 37611X209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     95973 | NS      | $1261085.22   | 1.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Genmab A/S                                     | Genmab A/S                                            | CUSIP: 000000000<br>LEI: 529900MTJPDPE4MHJ122 | Long             | EC               | CORP              | DK        |     20577 | NS      | $4430175.09   | 4.06%             |  |  |  | No            |                  2 | On Loan: No      |
| Arcturus Therapeutics Holdings Inc             | Arcturus Therapeutics Holdings Inc                    | CUSIP: 03969T109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     63703 | NS      | $777813.63    | 0.71%             |  |  |  | No            |                  1 | On Loan: No      |
| Roche Holding AG                               | Roche Holding AG                                      | CUSIP: 000000000<br>LEI: 549300U41AUUVOAAOB37 | Long             | EC               | CORP              | CH        |     13942 | NS      | $4350922.15   | 3.99%             |  |  |  | No            |                  2 | On Loan: No      |
| Intellia Therapeutics Inc                      | Intellia Therapeutics Inc                             | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |      9623 | NS      | $112011.72    | 0.10%             |  |  |  | No            |                  1 | On Loan: —       |
| BlackRock Funds III                            | BlackRock Cash Funds: Institutional, SL Agency Shares | CUSIP: 066922519<br>LEI: 5493008LW2651I1QB503 | Long             | STIV             | RF                | US        |  16265721 | NS      | $16272227.32  | 14.91%            |  |  |  | No            |                  1 | On Loan: No      |
| Revolution Medicines Inc                       | Revolution Medicines Inc                              | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |    110525 | NS      | $4119266.75   | 3.78%             |  |  |  | No            |                  1 | On Loan: No      |
| Moderna Inc                                    | Moderna Inc                                           | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |    165385 | NS      | $4888780.60   | 4.48%             |  |  |  | No            |                  1 | On Loan: No      |
| Iovance Biotherapeutics Inc                    | Iovance Biotherapeutics Inc                           | CUSIP: 462260100<br>LEI: 2549002L8WT2ACU5Q878 | Long             | EC               | CORP              | US        |    696710 | NS      | $1790544.70   | 1.64%             |  |  |  | No            |                  1 | On Loan: —       |
| ORIC Pharmaceuticals Inc                       | ORIC Pharmaceuticals Inc                              | CUSIP: 68622P109<br>LEI: 54930033FJRNEYBW0L25 | Long             | EC               | CORP              | US        |    102394 | NS      | $1020868.18   | 0.94%             |  |  |  | No            |                  1 | On Loan: No      |
| GSK PLC                                        | GSK PLC                                               | CUSIP: 000000000<br>LEI: 5493000HZTVUYLO1D793 | Long             | EC               | CORP              | GB        |    221908 | NS      | $4081771.65   | 3.74%             |  |  |  | No            |                  2 | On Loan: No      |
| Twist Bioscience Corp                          | Twist Bioscience Corp                                 | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |    143854 | NS      | $4829178.78   | 4.43%             |  |  |  | No            |                  1 | On Loan: —       |
| CRISPR Therapeutics AG                         | CRISPR Therapeutics AG                                | CUSIP: 000000000<br>LEI: 506700O6IRRIQLT3W370 | Long             | EC               | CORP              | CH        |      8263 | NS      | $464876.38    | 0.43%             |  |  |  | No            |                  1 | On Loan: —       |
| BeOne Medicines Ltd                            | BeOne Medicines Ltd                                   | CUSIP: 000000000<br>LEI: 549300JFUK6FRD5MH739 | Long             | EC               | CORP              | CH        |    228300 | NS      | $5190266.11   | 4.76%             |  |  |  | No            |                  2 | On Loan: No      |
| ImmunityBio Inc                                | ImmunityBio Inc                                       | CUSIP: 45256X103<br>LEI: 529900J9XLBR4HFL4B83 | Long             | EC               | CORP              | US        |    235549 | NS      | $579450.54    | 0.53%             |  |  |  | No            |                  1 | On Loan: —       |
| Incyte Corp                                    | Incyte Corp                                           | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |     66039 | NS      | $4945660.71   | 4.53%             |  |  |  | No            |                  1 | On Loan: No      |
| AstraZeneca PLC                                | AstraZeneca PLC                                       | CUSIP: 000000000<br>LEI: PY6ZZQWO2IZFZC3IOL08 | Long             | EC               | CORP              | GB        |     31140 | NS      | $4543065.48   | 4.16%             |  |  |  | No            |                  2 | On Loan: No      |
| Ono Pharmaceutical Co Ltd                      | Ono Pharmaceutical Co Ltd                             | CUSIP: 000000000<br>LEI: 529900G26L4NG4GFJZ86 | Long             | EC               | CORP              | JP        |     34900 | NS      | $390278.66    | 0.36%             |  |  |  | No            |                  2 | On Loan: No      |
| Arcellx Inc                                    | Arcellx Inc                                           | CUSIP: 03940C100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     66688 | NS      | $4760856.32   | 4.36%             |  |  |  | No            |                  1 | On Loan: —       |
| Chicago Mercantile Exchange                    | XAV HEALTH CARE SEP25                                 | CUSIP: 000000000<br>LEI: SNZ2OJLFK8MNNCLQOF39 | N/A              | DE               |  | US        |         1 | NC      | $-6909.24     | -0.01%            |  |  |  | No            |                  1 | On Loan: No      |
| Sanofi SA                                      | Sanofi SA                                             | CUSIP: 000000000<br>LEI: 549300E9PC51EN656011 | Long             | EC               | CORP              | FR        |     45104 | NS      | $4049014.40   | 3.71%             |  |  |  | No            |                  2 | On Loan: No      |
| OMNIAB INC                                     | OMNIAB INC                                            | CUSIP: 68218J202<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     19498 | NS      | $0.19         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| BLACKROCK CASH FUNDS TREASURY SL AGENCY SHARES | BlackRock Cash Funds: Treasury, SL Agency Shares      | CUSIP: 066922477<br>LEI: 5493008LW2651I1QB503 | Long             | STIV             | RF                | US        |     40000 | NS      | $40000.00     | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcus Biosciences Inc                          | Arcus Biosciences Inc                                 | CUSIP: 03969F109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    163895 | NS      | $1496361.35   | 1.37%             |  |  |  | No            |                  1 | On Loan: No      |
| Vir Biotechnology Inc                          | Vir Biotechnology Inc                                 | CUSIP: 92764N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    228550 | NS      | $1158748.50   | 1.06%             |  |  |  | No            |                  1 | On Loan: —       |
| Celcuity Inc                                   | Celcuity Inc                                          | CUSIP: 15102K100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     79136 | NS      | $3099361.44   | 2.84%             |  |  |  | No            |                  1 | On Loan: No      |
| Exelixis Inc                                   | Exelixis Inc                                          | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |    105542 | NS      | $3822731.24   | 3.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Takeda Pharmaceutical Co Ltd                   | Takeda Pharmaceutical Co Ltd                          | CUSIP: 000000000<br>LEI: 549300ZLMVP4X0OGR454 | Long             | EC               | CORP              | JP        |    152700 | NS      | $4194635.79   | 3.84%             |  |  |  | No            |                  2 | On Loan: No      |
| Regeneron Pharmaceuticals Inc                  | Regeneron Pharmaceuticals Inc                         | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |      9208 | NS      | $5022595.68   | 4.60%             |  |  |  | No            |                  1 | On Loan: No      |
| SK Bioscience Co Ltd                           | SK Bioscience Co Ltd                                  | CUSIP: 000000000<br>LEI: 988400F5SGZAXEGIAM36 | Long             | EC               | CORP              | KR        |     66285 | NS      | $2168783.46   | 1.99%             |  |  |  | No            |                  2 | On Loan: No      |
| Merck & Co Inc                                 | Merck & Co Inc                                        | CUSIP: 58933Y105<br>LEI: 4YV9Y5M8S0BRK1RP0397 | Long             | EC               | CORP              | US        |     57509 | NS      | $4492603.08   | 4.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Novavax Inc                                    | Novavax Inc                                           | CUSIP: 670002401<br>LEI: 529900J4GJHPEPQ23205 | Long             | EC               | CORP              | US        |    378659 | NS      | $2518082.35   | 2.31%             |  |  |  | No            |                  1 | On Loan: —       |
| Xencor Inc                                     | Xencor Inc                                            | CUSIP: 98401F105<br>LEI: 549300V5IF65437JKG30 | Long             | EC               | CORP              | US        |    171392 | NS      | $1425981.44   | 1.31%             |  |  |  | No            |                  1 | On Loan: No      |
| Janux Therapeutics Inc                         | Janux Therapeutics Inc                                | CUSIP: 47103J105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    127193 | NS      | $3054539.90   | 2.80%             |  |  |  | No            |                  1 | On Loan: —       |

### Signature

**Date Signed:** 2025-08-29

**Name of Applicant:** iShares Trust

**Signature:** Chuck Pulsfort

**Name of Signer:** Chuck Pulsfort

**Title:** Assistant Treasurer