# EDGAR Filing Document

**Accession Number:** 0001645460
**File Stem:** 0001193125-26-129018
**Filing Date:** 2026-3
**Character Count:** 2054
**Document Hash:** 7071a609c9e270871b72c26a4ea4d6bd
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-26-129018.hdr.sgml**: 20260505

**ACCESSION NUMBER**: 0001193125-26-129018

**CONFORMED SUBMISSION TYPE**: CORRESP

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20260327

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Cue Biopharma, Inc.
- **CENTRAL INDEX KEY:** 0001645460
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 473324577
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** CORRESP

**BUSINESS ADDRESS:**
- **STREET 1:** 40 GUEST STREET
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02135
- **BUSINESS PHONE:** 617-949-2680

**MAIL ADDRESS:**
- **STREET 1:** 40 GUEST STREET
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02135

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Imagen Biopharma, Inc.
- **DATE OF NAME CHANGE:** 20150617

**CUE BIOPHARMA, INC.** 

40 Guest Street

Boston, Massachusetts 02135

March 27, 2026

**VIA EDGAR** 

U.S. Securities and Exchange Commission

Division of Corporation Finance, Office of Life Sciences

100 F Street, N.E.

Washington, D.C. 20549

Attention: Tim Buchmiller

Re: Cue Biopharma, Inc.

Registration Statement on Form S-3

Filed March 16, 2026

File No. 333-294366

<u>Request for Acceleration</u>

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, Cue Biopharma, Inc. (the "<u>Registrant</u>") hereby requests acceleration of the effective date of its Registration Statement on Form S-3 (File No. 333-294366), so that it may become effective at 4:00 p.m. Eastern time on March 31, 2026, or as soon thereafter as practicable, or at such later time as the Registrant or its counsel may orally request via telephone call to the Staff.

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| | |
|:---|:---|
| Very truly yours, | Very truly yours, |
| **CUE BIOPHARMA, INC.** | **CUE BIOPHARMA, INC.** |
| By: | /s/ Lucinda Warren |
| Name: | Lucinda Warren |
| Title: | Interim President and Chief Executive Officer |

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