# EDGAR Filing Document

**Accession Number:** 0001534261
**File Stem:** 0000919574-26-001181
**Filing Date:** 2026-2
**Character Count:** 7716
**Document Hash:** 5758c471d783702bc1449d62101a9d84
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000919574-26-001181.hdr.sgml**: 20260217

**ACCESSION NUMBER**: 0000919574-26-001181

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20251231

**FILED AS OF DATE**: 20260217

**DATE AS OF CHANGE**: 20260217

**EFFECTIVENESS DATE**: 20260217

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Casdin Capital, LLC
- **CENTRAL INDEX KEY:** 0001534261

**ORGANIZATION NAME:**
- **EIN:** 800752351
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-17113
- **FILM NUMBER:** 26640870

**BUSINESS ADDRESS:**
- **STREET 1:** 1350 AVENUE OF THE AMERICAS
- **STREET 2:** SUITE 2600
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10019
- **BUSINESS PHONE:** 212-554-4952

**MAIL ADDRESS:**
- **STREET 1:** 1350 AVENUE OF THE AMERICAS
- **STREET 2:** SUITE 2600
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10019

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2025

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** Casdin Capital LLC<br>**Address:** 1350 Avenue of the Americas<br>Suite 2600<br>New York, NY 10019

**Form 13F File Number:** 028-17113

**CRD Number (if applicable):** 000169579

**SEC File Number (if applicable):** 801-110894

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Steve Giordano<br>**Title:** General Counsel<br>**Phone:** 646-661-3886

**Signature, Place, and Date of Signing:**

/s/ Steve Giordano  New York, NY  02-17-2026<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 38

**Form 13F Information Table Value Total:** $1609916188

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| 10X GENOMICS INC | CL A COM | 88025U109 |  | 22834000 | 1400000 | SH |  | SOLE |  | 1400000 | 0 | 0 |
| ABSCI CORPORATION | COM | 00091E109 |  | 3396677 | 973260 | SH |  | SOLE |  | 973260 | 0 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 |  | 29823750 | 75000 | SH |  | SOLE |  | 75000 | 0 | 0 |
| ARS PHARMACEUTICALS INC | COM | 82835W108 |  | 18640000 | 1600000 | SH |  | SOLE |  | 1600000 | 0 | 0 |
| AVIDITY BIOSCIENCES INC | COM | 05370A108 |  | 72130000 | 1000000 | SH |  | SOLE |  | 1000000 | 0 | 0 |
| BEAM THERAPEUTICS INC | COM | 07373V105 |  | 44352000 | 1600000 | SH |  | SOLE |  | 1600000 | 0 | 0 |
| BIOLIFE SOLUTIONS INC | COM NEW | 09062W204 |  | 144044250 | 5957165 | SH |  | SOLE |  | 5957165 | 0 | 0 |
| BRIDGEBIO ONCOLOGY THERAPEUT | COM NEW | 107924102 |  | 3534546 | 282312 | SH |  | SOLE |  | 282312 | 0 | 0 |
| CENTURY THERAPEUTICS INC | COM | 15673T100 |  | 1221803 | 1228190 | SH |  | SOLE |  | 1228190 | 0 | 0 |
| CONTINEUM THERAPEUTICS INC | CL A | 21217B100 |  | 1695446 | 148333 | SH |  | SOLE |  | 148333 | 0 | 0 |
| DENALI THERAPEUTICS INC | COM | 24823R105 |  | 30378400 | 1840000 | SH |  | SOLE |  | 1840000 | 0 | 0 |
| DEXCOM INC | COM | 252131107 |  | 11614750 | 175000 | SH |  | SOLE |  | 175000 | 0 | 0 |
| GENEDX HOLDINGS CORP | COM CL A | 81663L200 |  | 391111750 | 3007164 | SH |  | SOLE |  | 3007164 | 0 | 0 |
| GINKGO BIOWORKS HOLDINGS INC | CL A NEW | 37611X209 |  | 303257 | 36493 | SH |  | SOLE |  | 36493 | 0 | 0 |
| GUARDANT HEALTH INC | COM | 40131M109 |  | 38813200 | 380000 | SH |  | SOLE |  | 380000 | 0 | 0 |
| HIMS  HERS HEALTH INC | COM CL A | 433000106 |  | 12500950 | 385000 | SH |  | SOLE |  | 385000 | 0 | 0 |
| ILLUMINA INC | COM | 452327109 |  | 78696000 | 600000 | SH |  | SOLE |  | 600000 | 0 | 0 |
| INCYTE CORP | COM | 45337C102 |  | 9877000 | 100000 | SH |  | SOLE |  | 100000 | 0 | 0 |
| LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 |  | 4674100 | 215000 | SH |  | SOLE |  | 215000 | 0 | 0 |
| MAZE THERAPEUTICS INC | COM | 578784100 |  | 31439446 | 758857 | SH |  | SOLE |  | 758857 | 0 | 0 |
| MONTE ROSA THERAPEUTICS INC | COM | 61225M102 |  | 1348700 | 86014 | SH |  | SOLE |  | 86014 | 0 | 0 |
| NEUROGENE INC | COM | 64135M105 |  | 26684437 | 1295361 | SH |  | SOLE |  | 1295361 | 0 | 0 |
| PACIFIC BIOSCIENCES CALIF IN | COM | 69404D108 |  | 7898444 | 4223767 | SH |  | SOLE |  | 4223767 | 0 | 0 |
| PRIME MEDICINE INC | COM | 74168J101 |  | 10990097 | 3167175 | SH |  | SOLE |  | 3167175 | 0 | 0 |
| QUEST DIAGNOSTICS INC | COM | 74834L100 |  | 8676500 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| RECURSION PHARMACEUTICALS IN | CL A | 75629V104 |  | 676171 | 165323 | SH |  | SOLE |  | 165323 | 0 | 0 |
| RELAY THERAPEUTICS INC | COM | 75943R102 |  | 110010236 | 13003574 | SH |  | SOLE |  | 13003574 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 205284573 | 2577333 | SH |  | SOLE |  | 2577333 | 0 | 0 |
| SCHOLAR ROCK HLDG CORP | COM | 80706P103 |  | 11453000 | 260000 | SH |  | SOLE |  | 260000 | 0 | 0 |
| SEPTERNA INC | COM | 81734D104 |  | 15425112 | 553268 | SH |  | SOLE |  | 553268 | 0 | 0 |
| STANDARD BIOTOOLS INC | COM | 34385P108 |  | 113643336 | 88783856 | SH |  | SOLE |  | 88783856 | 0 | 0 |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 |  | 81721250 | 1175000 | SH |  | SOLE |  | 1175000 | 0 | 0 |
| TAYSHA GENE THERAPIES INC | COM SHS | 877619106 |  | 8250000 | 1500000 | SH |  | SOLE |  | 1500000 | 0 | 0 |
| TEMPUS AI INC | CL A | 88023B103 |  | 17368199 | 294127 | SH |  | SOLE |  | 294127 | 0 | 0 |
| TENAYA THERAPEUTICS INC | COM | 87990A106 |  | 257541 | 361969 | SH |  | SOLE |  | 361969 | 0 | 0 |
| THE CIGNA GROUP | COM | 125523100 |  | 11009200 | 40000 | SH |  | SOLE |  | 40000 | 0 | 0 |
| UNITEDHEALTH GROUP INC | COM | 91324P102 |  | 16505500 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| VERACYTE INC | COM | 92337F107 |  | 11632567 | 276308 | SH |  | SOLE |  | 276308 | 0 | 0 |

---