# EDGAR Filing Document

**Accession Number:** 0001729214
**File Stem:** 0001171843-26-001172
**Filing Date:** 2026-2
**Character Count:** 192442
**Document Hash:** 12a39225fd1a66d13200c5f849d3d483
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001171843-26-001172.hdr.sgml**: 20260227

**ACCESSION NUMBER**: 0001171843-26-001172

**CONFORMED SUBMISSION TYPE**: 6-K

**PUBLIC DOCUMENT COUNT**: 8

**CONFORMED PERIOD OF REPORT**: 20251231

**FILED AS OF DATE**: 20260227

**DATE AS OF CHANGE**: 20260227

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** XORTX Therapeutics Inc.
- **CENTRAL INDEX KEY:** 0001729214
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** A1
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 6-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-40858
- **FILM NUMBER:** 26692646

**BUSINESS ADDRESS:**
- **STREET 1:** SUITE 2400 - 745 THURLOW STREET
- **CITY:** VANCOUVER
- **STATE:** A1
- **ZIP:** V6E 0C5
- **BUSINESS PHONE:** 403-607-2621

**MAIL ADDRESS:**
- **STREET 1:** SUITE 2400 - 745 THURLOW STREET
- **CITY:** VANCOUVER
- **STATE:** A1
- **ZIP:** V6E 0C5

**UNITED STATES<br> SECURITIES AND EXCHANGE COMMISSION**<br> **Washington, D.C. 20549**<br>**Form 6-K**<br>**REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16<br> UNDER THE SECURITIES EXCHANGE ACT OF 1934**<br>

**For the month of February 2026**

**Commission File Number: 001-40858**

**XORTX Therapeutics Inc.**

**3710 – 33<sup>rd</sup> Street NW, Calgary, Alberta, T2L 2M1**

Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.

Form 20-F ☒ Form 40-F ☐

**SIGNATURE**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

---

| | | | |
|:---|:---|:---|:---|
|  |  | **XORTX THERAPEUTICS INC.** | **XORTX THERAPEUTICS INC.** |
|  |  | (Registrant) | (Registrant) |
| Date: | February 26, 2026 | By: | */s/ Allen Davidoff* |
|  |  | Name: | Allen Davidoff |
|  |  | Title: | Chief Executive Officer<br>|

---

**<u>EXHIBIT INDEX</u>**

---

| | |
|:---|:---|
| [99.1](exh_991.htm)<br>| [Consolidated Financial Statements for the years ended December 31, 2025, 2024 and 2023](exh_991.htm)<br>|
| [99.2](exh_992.htm) | [Management Discussion and Analysis for the year ended December 31, 2025](exh_992.htm) |

---

## Exhibit 99.1

**Exhibit 99.1**

**CONSOLIDATED FINANCIAL STATEMENTS**

**As at and for the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

![](davidson.jpg)

**REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM**

To the Shareholders and Directors of

XORTX Therapeutics Inc.

#### Opinion on the Consolidated Financial Statements
We have audited the accompanying consolidated statements of financial position of XORTX Therapeutics Inc. (the "Company") as of December 31, 2025 and 2024, and the related consolidated statements of loss and comprehensive loss, changes in shareholders' equity, and cash flows for the years ended December 31, 2025 and 2024 and the related notes (collectively referred to as the "financial statements"). In our opinion, the financial statements present fairly, in all material respects, the financial position of the Company as of December 31, 2025 and 2024, and the results of its operations and its cash flows for the years ended December 31, 2025 and 2024 in conformity with IFRS Accounting Standards as issued by the International Accounting Standards Board ("IFRS Accounting Standards").

#### Going Concern
The accompanying financial statements have been prepared assuming that the Company will continue as a going concern. As discussed in Note 1 to the financial statements, the Company will have to finance its research and development activities and if the Company is unsuccessful in obtaining adequate financing in the future, research activities will be postponed. These circumstances and conditions indicate the existence of a material uncertainty that raises substantial doubt about its ability to continue as a going concern. Management's plans in regard to these matters are also described in Note 1. The financial statements do not include any adjustments that might result from the outcome of this uncertainty.

#### Basis for Opinion
These financial statements are the responsibility of the Company's management. Our responsibility is to express an opinion on these financial statements based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) ("PCAOB") and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement, whether due to error or fraud. The Company is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the entity's internal control over financial reporting. Accordingly, we express no such opinion.

Our audits included performing procedures to assess the risks of material misstatement of the financial statements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements. We believe that our audits provide a reasonable basis for our opinion.

DAVIDSON & COMPANY LLP 1200 - 609 Granville Street 604 687 0947 <br> PO BOX 10372, Pacific Centre davidson-co.com <br> Vancouver, BC V7Y 1G6

We have served as the Company's auditor since 2025.

#### /s/ DAVIDSON & COMPANY LLP
Chartered Professional Accountants Vancouver, Canada

February 25, 2026

![](smythe.jpg)

**REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM**

#### TO THE SHAREHOLDERS AND DIRECTORS OF XORTX THERAPEUTICS INC.

#### Opinion on the Consolidated Financial Statements
 ****

We have audited the accompanying consolidated statements of loss and comprehensive loss, changes in shareholders' equity and cash flows of Xortx Therapeutics Inc. and its subsidiaries (the "Company") for the year ended December 31, 2023, and the related notes (collectively referred to as the "consolidated financial statements"). In our opinion, the consolidated financial statements, present fairly, in all material respects, the results of operations and cash flows of the Company for the year ended December 31, 2023, in conformity with IFRS Accounting Standards as issued by the International Accounting Standards Board.

#### Basis for Opinion
 ****

These consolidated financial statements are the responsibility of the Company's management. Our responsibility is to express an opinion on the Company's consolidated financial statements based on our audit. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) ("PCAOB") and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audit in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the consolidated financial statements are free of material misstatement, whether due to error or fraud. The Company is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audit, we are required to obtain an understanding of internal control over financial reporting, but not for the purpose of expressing an opinion on the effectiveness of the Company's internal control over financial reporting. Accordingly, we express no such opinion.

Our audit included performing procedures to assess the risks of material misstatement of the consolidated financial statements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the consolidated financial statements. Our audit also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the consolidated financial statements. We believe that our audit provides a reasonable basis for our opinion.

![](smythe_2.jpg)

![](smythe.jpg)

#### Critical Audit Matters
 ****

Critical audit matters are matters arising from the current period audit of the consolidated financial statements that were communicated or required to be communicated to the audit committee and that

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) relate to accounts or disclosures that are material to the consolidated financial statements and (2) involved our especially challenging, subjective, or complex judgments. We determined that there are no critical audit matters.

We have served as the Company's auditor since 2018.

![](smythe_sig.jpg)

Chartered Professional Accountants

Vancouver, Canada

April 1, 2024

![](smythe_2.jpg)

**XORTX THERAPEUTICS INC.**

**Consolidated Statements of Financial Position**

**(Expressed in U.S. Dollars)**

---

| |
|:---|
| **Assets** |
| **Current** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Cash |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Accounts receivable |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Prepaid expenses |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Deferred acquisition costs |
| **Total Current Assets** |
| **Non-current** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Contract payments |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Intangible assets |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Property and equipment |
| **Total Assets** |
| **Liabilities** |
| **Current** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Accounts payable and accrued liabilities |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Derivative warrant liability |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Lease obligation |
| **Total Liabilities** |
| **Shareholders' Equity** |
| Share capital |
| Reserves |
| Obligation to issue shares |
| Accumulated other comprehensive loss) |
| Accumulated deficit |
| **Total Shareholders' Equity** |
| **Total Liabilities and Shareholders' Equity** |

---

Nature of operations and going concern (Note 1)

Commitments (Note 17)

Subsequent event (Note 19)

---

| | |
|:---|:---|
| */s/ "Allen Davidoff"* | */s/ "Paul Van Damme"* |
| Director | Director |

---

The accompanying notes are an integral part of these consolidated financial statements.

**XORTX THERAPEUTICS INC.**

**Consolidated Statements of Loss and Comprehensive Loss** 

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

---

| |
|:---|
| **Expenses** |
| Research and development |
| Consulting, wages and benefits |
| Directors' fees |
| Investor relations |
| Professional fees |
| General and administrative |
| Public company costs |
| Travel |
| Amortization of property and equipment |
| Amortization of intangible assets |
| Impairment of intangible assets |
| Share-based payments |
| **Loss before other items)** **))** |
| Fair value adjustment on derivative warrant liability |
| Foreign exchange loss) |
| Interest income |
| Transaction costs on derivative warrant liability |
| **Total loss and comprehensive loss for the year** |
| **Basic and diluted loss per common share** |
| Weighted average number of common shares outstanding - Basic and diluted |

---

The accompanying notes are an integral part of these consolidated financial statements.

**XORTX THERAPEUTICS INC.**

**Consolidated Statements of Changes in Shareholders' Equity** 

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Number of<br> common <br> shares** | **Share <br> capital** | **Reserves** | **Obligation <br> to issue <br> shares** |
| **Balance, December 31, 2022** | **1670071))** |  |  |  |
| Reclassification of derivative warrant liability | -) |  |  |  |
| Pre-funded warrants exercised | 328777) |  |  |  |
| Share-based payments |  |  |  |  |
| Comprehensive loss for the year | - |  |  |  |
| **Balance, December 31, 2023** | **1998848))** |  |  |  |
| Shares issued pursuant to private placement | 1219717 |  |  |  |
| Pre-funded warrants issued |  |  |  |  |
| Reclassification of derivative warrant liability |  |  |  |  |
| Share issuance costs | -) |  |  |  |
| Pre-funded warrants exercised | 257810) |  |  |  |
| Warrants exercised | 5000 |  |  |  |
| Share-based payments |  |  |  |  |
| Comprehensive loss for the year | - |  |  |  |
| **Balance, December 31, 2024** | **3481375))** |  |  |  |
| Shares issued pursuant to at-the-market offering | 73871 |  |  |  |
| Shares issued pursuant to private placement | 1996442 |  |  |  |
| Pre-funded warrants issued |  |  |  |  |
| Share issuance costs | -) |  |  |  |
| Pre-funded warrants exercised | 1410530) |  |  |  |
| Reversal of obligation to issue shares upon termination of agreement | -) |  |  |  |
| Share-based payments |  |  |  |  |
| Comprehensive loss for the year | - |  |  |  |
| **Balance, December 31, 2025** | **6962218** |  |  |  |

---

The accompanying notes are an integral part of these consolidated financial statements.

**XORTX THERAPEUTICS INC.**

**Consolidated Statements of Cash Flows**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

   
**2025**  
 **2024** 
  **2023**

**$**
**$**
**$**
**Cash provided by (used in):**
**Operating activities**
&nbsp;&nbsp;&nbsp;&nbsp;Net loss for the year (2,656,304) (3,313,346)
(2,158,065) &nbsp;&nbsp;&nbsp;&nbsp;Items
not affecting cash:
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Amortization 112,115
117,274 139,694 &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Fair value
adjustment on derivative warrant liability (564,000)
(1,035,105) (3,641,403)
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Impairment of intangible assets
1,833 - - &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Share-
based payments 25,155 122,527 120,984
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Transaction costs on derivative warrant
liability - 279,031 -
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Unrealized foreign exchange (gain) loss
(23,739) 34,178 (13,634) &nbsp;&nbsp;&nbsp;&nbsp;Changes in non-
cash operating assets and liabilities:
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Accounts receivable (62,535)
43,074 21,041 &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Prepaid
expenses 162,803 208,166 142,654
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Accounts payable and accrued liabilities
  235,949   
(134,447)   (1,194,436)   (2,768,723)
  (3,678,648) 
 (6,583,165)
**Investing activities**
&nbsp;&nbsp;&nbsp;&nbsp;Acquisition of intangible assets (55,223)
(38,924) (42,052) &nbsp;&nbsp;&nbsp;&nbsp;Acquisition of equipment
- - (4,311) &nbsp;&nbsp;&nbsp;&nbsp;Deferred acquisition costs
  (239,730)  
-    - 
  (294,953)  
(38,924)   (46,363)
**Financing activities**
&nbsp;&nbsp;&nbsp;&nbsp;Pre-funded warrants and warrants exercised 14
16,573 296 &nbsp;&nbsp;&nbsp;&nbsp;Payment of lease obligation
(89,572) (69,723) (66,089) &nbsp;&nbsp;&nbsp;&nbsp;Cash share
issuance costs (738,433) (667,883) (295,251)
&nbsp;&nbsp;&nbsp;&nbsp;Proceeds from issuance of equity instruments 
 2,255,535   
3,500,542    - 
  1,427,544   
2,779,509    (361,044)
**Effect of foreign exchange loss (gain) on
cash**   26,997 
  (35,953)  
4,041 
**Decrease in cash** (1,609,135)
(974,016) (6,986,531)
**Cash, beginning of year** 
 2,473,649   
3,447,665    10,434,196

**Cash, end of year** 
 864,514   
2,473,649    3,447,665

**Supplemental Cash Flow and Non-Cash Investing
<br>and Financing Activities Disclosure**
&nbsp;&nbsp;&nbsp;Fair value of agent's warrants 38,484
- - &nbsp;&nbsp;&nbsp;Derivative warrant liability
reclassified to share capital on exercise of warrants -
5,244 - &nbsp;&nbsp;&nbsp;Recognition of right-of-use
asset 88,074 96,998 -
&nbsp;&nbsp;&nbsp;Deferred financing costs reclassified to share
capital and transaction costs on derivative warrant liability -
166,344 - &nbsp;&nbsp;&nbsp;Share issuance costs in
accounts payable 113,299 - -
&nbsp;&nbsp;&nbsp;Deferred acquisition costs in accounts payable
54,073 - -
The accompanying notes are an integral part of these consolidated financial statements.

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**1.** **Nature of operations and going concern** 

XORTX Therapeutics Inc. (the "Company" or "XORTX") was incorporated under the laws of Alberta, Canada on August 24, 2012.

XORTX is a public company listed on the TSX Venture Exchange (the "TSXV") and on the Nasdaq Stock Market ("Nasdaq") under the symbol "XRTX". The Company's operations and mailing address is 3710 – 33<sup>rd</sup> Street NW, Calgary, Alberta, Canada T2L 2M1 and its registered address is located at 550 Burrard Street, Suite 2900, Vancouver, British Columbia, V6C 0A3. The Company has received a notice of non-compliance from Nasdaq relating to the minimum bid price requirement and is working to regain compliance within the prescribed period.

XORTX is a late-stage clinical pharmaceutical company focused on developing innovative therapies to treat gout and progressive kidney disease modulated by aberrant purine and uric acid metabolism in orphan disease indications such as allopurinol intolerant gout and autosomal dominant polycystic kidney disease, as well as more prevalent type 2 diabetic nephropathy, and fatty liver disease. The Company's current focus is on developing products to slow and/or reverse the progression of these diseases.

The Company is subject to a number of risks associated with the successful development of new products and their marketing and the conduct of its clinical studies and their results. The Company will have to finance its research and development activities and its clinical studies. To achieve the objectives in its business plan, the Company plans to raise the necessary capital and to generate revenues. Although there is no certainty, management is of the opinion that additional funding for future projects and operations can be raised as needed. The products developed by the Company will require approval from the U.S. Food and Drug Administration and equivalent organizations in other countries before their sale can be authorized. If the Company is unsuccessful in obtaining adequate financing in the future, research activities will be postponed until market conditions improve. These circumstances and conditions indicate the existence of a material uncertainty that casts significant doubt about the Company's ability to continue as a going concern.

&nbsp;&nbsp;&nbsp;&nbsp;**2.** **Basis of preparation** 

**Statement of Compliance** 

These consolidated financial statements have been prepared in accordance with IFRS Accounting Standards ("IFRS") as issued by the International Accounting Standards Board ("IASB").

**Basis of Measurement and Presentation** 

These consolidated financial statements have been prepared using the historical cost convention except for financial instruments which have been measured at fair value. These consolidated financial statements were prepared on an accrual basis except for cash flow information.

These consolidated financial statements incorporate the financial statements of the Company and its 100% owned subsidiary. The accounts of the Company's subsidiary are prepared for the same reporting period as the parent company, using consistent accounting policies. Inter-company transactions, balances and unrealized gains or losses on transactions are eliminated. The Company's subsidiary is the following:

---

| | |
|:---|:---|
| &nbsp;&nbsp;**Name** | **Ownership** |
| &nbsp;&nbsp;XORTX Pharma Corp. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Canada | 100% |

---

These consolidated financial statements were approved for issue by the Board of Directors on February 25, 2026.

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**3.** **Material accounting policies** 

These consolidated financial statements have been prepared using the following accounting policies:

**Financial Instruments**

&nbsp;&nbsp;&nbsp;&nbsp;**a)** **Classification** 

The Company classifies its financial instruments in the following categories: at fair value through profit or loss ("FVTPL"), at fair value through other comprehensive income (loss) ("FVTOCI") or at amortized cost. The Company determines the classification of financial assets at initial recognition. The classification of debt instruments is driven by the Company's business model for managing the financial assets and their contractual cash flow characteristics.

Equity instruments that are held for trading are classified as FVTPL. For other equity instruments, on the day of acquisition the Company can make an irrevocable election (on an instrument-by-instrument basis) to designate them as at FVTOCI. Financial liabilities are measured at amortized cost, unless they are required to be measured at FVTPL (such as instruments held for trading or derivatives) or if the Company has opted to measure them at FVTPL.

The following are the Company's financial instruments as at December 31, 2025 and 2024:

---

| | |
|:---|:---|
|  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**Classification** |
| Cash | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Amortized cost |
| Accounts receivable | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Amortized cost |
| Contract payments | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Amortized cost |
| Accounts payable and accrued liabilities | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Amortized cost |
| Derivative warrant liability | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;FVTPL |
| Lease obligations | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Amortized cost |

---

&nbsp;&nbsp;&nbsp;&nbsp;**b)** **Measurement** 

**Financial assets at FVTOCI**

Elected investments in equity instruments at FVTOCI are initially recognized at fair value plus transaction costs. Subsequently they are measured at fair value, with gains and losses recognized in other comprehensive income (loss).

**Financial assets and liabilities at amortized cost**

Financial assets and liabilities at amortized cost are initially recognized at fair value plus or minus transaction costs, respectively, and subsequently carried at amortized cost using the effective interest rate, less any impairment.

**Financial assets and liabilities at FVTPL**

Financial assets and liabilities carried at FVTPL are initially recorded at fair value and transaction costs are expensed in the consolidated statements of comprehensive loss. Realized and unrealized gains and losses arising from changes in the fair value of the financial assets and liabilities held at FVTPL are included in the consolidated statements of comprehensive loss in the period in which they arise. Where management has opted to recognize a financial liability at FVTPL, any changes associated with the Company's own credit risk will be recognized in other comprehensive loss.

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**3.** **Material Accounting policies (continued)** 

**Financial Instruments (continued)**

**Impairment of financial assets at amortized cost**

The Company recognizes a loss allowance for expected credit losses on financial assets that are measured at amortized cost.

At each reporting date, the Company measures the loss allowance for the financial asset at an amount equal to the lifetime expected credit losses if the credit risk on the financial asset has increased significantly since initial recognition. If at the reporting date, the financial asset has not increased significantly since initial recognition, the Company measures the loss allowance for the financial asset at an amount equal to the twelve month expected credit losses. The Company shall recognize in the consolidated statements of comprehensive loss, as an impairment gain or loss, the amount of expected credit losses (or reversal) that is required to adjust the loss allowance at the reporting date to the amount that is required to be recognized.

&nbsp;&nbsp;&nbsp;&nbsp;**c)** **Derecognition** 

**Financial assets**

The Company derecognizes financial assets only when the contractual rights to cash flows from the financial assets expire, or when it transfers the financial assets and substantially all of the associated risks and rewards of ownership to another entity. Gains and losses on derecognition are generally recognized in profit or loss. However, gains and losses on derecognition of financial assets classified as FVTOCI remain within accumulated other comprehensive income (loss).

**Financial liabilities**

The Company derecognizes financial liabilities only when its obligations under the financial liabilities are discharged, cancelled or expired. Generally, the difference between the carrying amount of the financial liability derecognized and the consideration paid and payable, including any non-cash assets, is recognized in the consolidated statements of loss and comprehensive loss.

**Cash** 

Cash include cash on hand, held at banks, or held with investment brokers as well as short-term investments with an original maturity of 90 days or less, which are readily convertible into known amounts of cash.

**Equipment**

Equipment is recorded at cost less accumulated amortization and accumulated impairment losses. The cost of an item of equipment includes expenditures that are directly attributable to the acquisition thereof. Amortization is calculated on bases and rates designed to amortize the cost of the assets over their estimated useful lives. Amortization is recorded using the straight-line method with an expectation of the following useful life estimates:

Computer equipment 3 years

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**3.** **Material Accounting policies (continued)** 

**Leases**

At inception of a contract, the Company assesses whether a contract is, or contains, a lease determining whether the contract conveys the right to control the use of an identified asset for a period of time in exchange for consideration. To assess whether a contract conveys the right to control the use of an identified asset, we assess whether:

&nbsp;&nbsp;&nbsp;&nbsp;· the contract involves the use of an identified asset;

&nbsp;&nbsp;&nbsp;&nbsp;· the Company has the right to obtain substantially all of the economic benefits from use of the identified
asset throughout the period of use; and

&nbsp;&nbsp;&nbsp;&nbsp;· the Company has the right to direct the use of the identified asset.

The right-of-use asset and corresponding lease obligation is recognized at the lease commencement date. The right-of-use asset is initially measured at cost, which comprises the initial amount of the lease obligation adjusted for any lease payments made at or before the commencement date, plus any initial direct costs incurred and an estimate of costs to dismantle and remove the underlying asset or to restore the underlying asset or the site on which it is located, less any lease incentives received. The right-of-use asset is subsequently depreciated using the straight-line method from the commencement date to the end of the lease term or its useful life, whichever is shorter. The lease term includes periods covered by an option to extend if the Company is reasonably certain to exercise that option. In addition, the right-of-use asset is reduced by impairment losses and adjusted for certain remeasurements of the lease obligation, if any.

The lease obligation is initially measured at the present value of the lease payments that are not paid at the commencement date. The lease payments are discounted using the implicit interest rate in the lease. If the rate cannot be readily determined, the Company's incremental rate of borrowing is used. The lease obligation is subsequently measured at amortized cost using the effective interest method. The lease obligation is remeasured when there is a change in future lease payments arising from a change in an index or rate, if there is a change in our estimate of the amount expected to be payable under a residual value guarantee, if we change our assessment of whether we will exercise a purchase, extension or termination option, or if the underlying lease contract is amended.

The Company has elected not to separate fixed non-lease components from lease components and instead account for each lease component and associated fixed non-lease components as a single lease component.

The Company has elected not to recognize right-of-use assets and lease obligations for short-term leases that have a lease term of 12 months or less and for leases of low value assets. The lease payments associated with those leases are recognized as an expense on a straight-line basis over the lease term.

**Research and development costs**

Research costs including clinical trial costs are expensed as incurred, net of recoveries until a drug product receives regulatory approval. Development costs that meet specific criteria related to technical, market and financial feasibility will be capitalized. To date, all research and development costs have been expensed.

**Intangible assets**

Intangible assets are measured at cost less accumulated amortization and accumulated impairment losses. Costs incurred for patents, patents pending and licenses are capitalized and amortized from the date of capitalization on a straight-line basis over the shorter of their respective remaining estimated lives or 20 years.

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**3.** **Material Accounting policies (continued)** 

**Government assistance**

Amounts received or receivable resulting from government assistance programs, including grants and investment tax credits for research and development, are recognized where there is reasonable assurance that the amount of government assistance will be received and all attached conditions will be complied with. Investment tax credits and grants relating to qualifying scientific research and experimental development expenditures that are recoverable are recognized as a reduction of expenses.

**Impairment of long-lived assets**

Intangible assets and equipment are tested for impairment when events or changes in circumstances indicate that the carrying amount may not be recoverable. For the purpose of measuring recoverable amounts, assets are grouped at the lowest levels for which there are separately identifiable cash flows (cash-generating units or CGUs). The recoverable amount is the higher of an asset's fair value less costs to sell, and its value in use (being the present value of the expected future cash flows of the relevant asset or CGU). An impairment loss is recognized for the amount by which the asset's carrying amount exceeds its recoverable amount. The Company evaluates impairment losses for potential reversals when events or circumstances warrant such consideration.

**Derivative warrant liabilities**

Derivative warrant liabilities issued in relation to equity offerings that fail to meet the definition of equity are classified as derivative liabilities and measured at fair value with changes in fair value recognized in profit or loss at each period end. In instances where units consisting of a common share and a warrant classified as a derivative liability are issued, the Company recognizes the unit as a compound financial instrument. In accordance with IAS 32 Financial Instruments: Presentation, when a compound instrument has been determined to contain a financial liability and an equity component, the fair value of the instrument is bifurcated by first determining the fair value of the liability, and then allocating any residual value to the equity instrument.

The derivative warrants will ultimately be converted into the Company's equity (common shares) when the warrants are exercised or will be extinguished on the expiry of the outstanding warrants and will not result in the inflow of any cash to the Company. Immediately prior to exercise, the warrants are remeasured at their intrinsic value (the intrinsic value being the share price at the date the warrant is exercised less the exercise price of the warrant), and this value is transferred to Share Capital on exercise. Any remaining fair value is recorded through profit or loss as part of the change in estimated fair value of the derivative warrant liabilities.

The Company uses the Black-Scholes option pricing model to estimate fair value at each period end date. The key assumptions used in the model are described in Note 12(h).

**Share-based payments**

The Company has a stock option plan that is described in Note 12 and grants share options to acquire common shares of the Company to directors, officers, employees and consultants. Share-based payments to employees are measured at the fair value of the instruments granted. Share-based payments to non-employees are measured at the fair value of the goods or services received or the fair value of the equity instruments issued as calculated using the Black-Scholes option pricing model if the fair value of the goods or services cannot be reliably measured. The offset to the recorded expense is to reserves.

Consideration received on the exercise of stock options is recorded as share capital and the recorded amount in reserves is transferred to share capital.

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**3.** **Material Accounting policies (continued)** 

**Share capital**

Common shares are classified as equity. Costs directly identifiable with share capital financing are charged against share capital. Share issuance costs incurred in advance of share subscriptions are recorded as deferred assets. Share issuance costs related to uncompleted share subscriptions are charged to operations in the period they are incurred.

The Company's common shares, pre-funded warrants, warrants (other than derivative warrants) and options are classified as equity instruments. Incremental costs directly related to the issue of new shares or options are shown in equity as a deduction from the proceeds. For equity offerings of units consisting of a common share and warrant, when both instruments are classified as equity, the Company allocates proceeds first to common shares based on the estimated fair value of the common shares at the time the units are issued, with any excess value allocated to warrants.

From time to time in connection with private placements and other equity offerings, the Company issues compensatory warrants ("Finders' Warrants") or warrant units ("Finders' Warrant Units") to agents as commission for services. Awards of Finders' Warrants and Finders' Warrant Units are accounted for in accordance with the fair value method of accounting and result in share issuance costs and a credit to reserves when Finders' Warrants and Finders' Warrant Units are issued. The fair value of Finders' Warrants is measured using the Black-Scholes option pricing model and the fair value of the Finders' Warrant Units is measured using the Geske compound option pricing model that requires the use of certain assumptions regarding the risk-free market interest rate, expected volatility in the price of the underlying stock, and expected life of the instruments.

**Earnings (loss) per common share**

Basic earnings (loss) per common share is computed by dividing the net income (loss) available to common shareholders by the weighted average number of common shares outstanding during the period. Diluted earnings per share reflect the potential dilution that could share in the earnings of an entity. In the periods where a net loss is incurred, potentially dilutive common shares (outstanding vested stock options and share purchase warrants) are excluded from the loss per share calculation as the effect would be anti-dilutive and basic and diluted loss per common share are the same. In a profit year, the weighted average number of common shares outstanding used for the calculation of diluted earnings per share assumes that the proceeds to be received on the exercise of dilutive stock options and warrants are used to repurchase the common shares at the average price per period.

**Foreign currency translation**

The presentation and functional currency of the Company and its subsidiary is the U.S. dollar. Foreign currency transactions are translated into U.S. dollars using the exchange rates prevailing at the dates of the transactions. Monetary assets and liabilities denominated in foreign currencies are translated at the rate of exchange in effect as of the financial position date. Gains and losses are recognized in profit or loss on a current basis.

**Income taxes**

The Company uses the asset and liability method of accounting for income taxes. Under this method, deferred tax assets and liabilities are recognized for the future tax consequences attributable to differences between the financial statement carrying amounts of existing assets and liabilities and their respective tax bases. Deferred tax assets and liabilities are measured using substantively enacted tax rates expected to apply to taxable income in the years in which those temporary differences are expected to be recovered or settled.

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**3.** **Material Accounting policies (continued)** 

Deferred income tax assets also result from unused loss carry forwards, resource related pools and other deductions. A deferred tax asset is recognized for unused tax losses, tax credits and deductible temporary differences to the extent that it is probable that future taxable profits will be available against which they can be utilized. Deferred tax assets are reviewed at each reporting date and are reduced to the extent that it is no longer probable that the related tax benefit will be realized.

**New and recent accounting pronouncements**

In April 2024, IASB issued IFRS 18, Presentation and Disclosure in Financial Statements to replace IAS 1, Presentation of Financial Statements. The aim of IFRS 18 is to set out requirements for presentation and disclosure of financial statements to ensure the entity provides relevant and accurate information about its assets, liabilities, equity, income and expenses. IFRS 18 is effective for the Company as of January 1, 2027. The Company is assessing the impact of this standard on the consolidated financial statements.

&nbsp;&nbsp;&nbsp;&nbsp;**4.** **Critical accounting judgments and estimates** 

The preparation of consolidated financial statements requires management to make judgments and estimates that affect the amounts reported in the consolidated financial statements and notes. By their nature, these judgments and estimates are subject to change and the effect on the consolidated financial statements of changes in such judgments and estimates in future periods could be material. These judgments and estimates are based on historical experience, current and future economic conditions, and other factors, including expectations of future events that are believed to be reasonable under the circumstances. Actual results could differ from these judgments and estimates.

Revisions to accounting estimates are recognized in the period in which the estimate is revised and may affect both the period of revision and future periods. Information about critical accounting judgments in applying accounting policies that have the most significant risk of causing material adjustment to the carrying amounts of assets and liabilities recognized in the consolidated financial statements within the next financial year are discussed below:

**Share-based payment transactions and warrant liabilities**

The Company measures the cost of equity-settled transactions with employees by reference to the fair value of the equity instruments at the date at which they are granted. Warrant liabilities are accounted for as derivative liabilities if the proceeds from exercise are either not fixed, denominated in a currency other than the functional currency, or can be settled on a net basis, and therefore do not meet the fixed for fixed criteria. Estimating fair value for share-based transactions requires determining the most appropriate valuation model, which is dependent on the terms and conditions of the instrument. This estimate also requires determining the most appropriate inputs to the valuation model including the expected life of the share option or warrant, volatility and dividend yield and making assumptions about them.

**Classification of contract payments**

In concluding that contract payments are a non-current asset, management considered when future regulatory and clinical trial programs are anticipated to be completed. Management assessed that the future regulatory and clinical trial programs would not be completed within 12 months from period end and therefore classified the contract payments as a non-current asset.

&nbsp;&nbsp;&nbsp;&nbsp;**4.** **Critical accounting judgments and estimates (continued)** 

**Impairment of intangible assets**

Patents (obtained and pending) and licenses are reviewed for impairment at each financial reporting date. If, in the judgment of management, future economic benefits will not flow to the Company, then the Company will assess the recoverable value of the asset. If the carrying value is greater than the recoverable value, the asset will be impaired to the recoverable value.

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

**Determination of functional currency**

In concluding that the U.S. dollar is the functional currency of the Company and its subsidiary, management considered the currency that mainly influences the cost of providing goods and services in the primary economic environment in which each entity operates and the currency in which funds from financing are generated, or if there has been a change in events or conditions that determined the primary economic environment.

**Treatment of research and development costs**

Costs to develop products are capitalized to the extent that the criteria for recognition as intangible assets in IAS 38 Intangible Assets are met. Those criteria require that the product is technically and economically viable, the Company has the intention and ability to use the asset, and how the asset will generate future benefits. Management assessed the capitalization of development costs based on the attributes of the development project, perceived user needs, industry trends and expected future economic conditions. Management considers these factors in aggregate and applies significant judgment to determine whether the product is feasible. The Company has not capitalized any development costs as at December 31, 2025.

**Leases**

Value of right-of-use assets and lease obligations require judgement in determining lease terms such as extension options, determining whether a lease contract contains an identified asset to which the Company has the right to use substantially all of the economic benefits from, and the incremental borrowing rate applied. The Company estimates the incremental borrowing rate based on the lease term, collateral assumptions and the economic environment in which the lease exists. Renewal options are only included if management is reasonably certain that the option will be renewed.

**Classification of pre-funded warrants**

Management applied judgment when determining the appropriate classification of pre-funded warrants included in unit offerings. Management considered the characteristics of derivative instruments and concluded that the pre-funded warrants should be classified as an equity instrument.

**Current and deferred taxes**

The measurement of income taxes payable and deferred income tax assets and liabilities requires management to make judgments in the interpretation and application of the relevant tax laws. Such differences may result in eventual tax payments differing from amounts accrued. Reported amounts for deferred tax assets and liabilities are based on management's expectation for the timing and amounts of future taxable income or loss, as well as future taxation rates. Changes to these underlying estimates may result in changes to the carrying value, if any, of deferred income tax assets and liabilities.

&nbsp;&nbsp;&nbsp;&nbsp;**5.** **Cash** 

The Company's cash consists of cash held and interest-bearing deposits with the Company's bank and brokerage accounts. The current annual interest rate earned on these deposits is 2.10% to 3.50% (2024 – 3.62%).

---

| | | |
|:---|:---|:---|
| | **December 31,**<br> **2025**  | **December 31,**<br> **2024**  |
|  | **$** | **$** |
| Cash | 244022 | 53686 |
| Interest-bearing deposits | 620492 | 2419963 |
|  | 864514 | 2473649 |

---

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**6.** **Prepaid expenses** 

The Company's prepaid expenses relate to the following:

---

| | | |
|:---|:---|:---|
| | **December 31, <br>2025** | **December 31, <br>2024** |
|  | **$** | **$** |
| Research and development |  | 1167 |
| Insurance | 2582 | 158007 |
| Investor relations conferences and services | 12464 | 19490 |
| Administrative services and other | 7563 | 6748 |
|  | 22609 | 185412 |

---

&nbsp;&nbsp;&nbsp;&nbsp;**7.** **Contract payments** 

During the year ended December 31, 2020, the Company entered into an agreement with Prevail InfoWorks Inc. As part of the agreement, the Company paid $1,200,000 through the issuance of units in the private placement that closed February 28, 2020, to be applied to future regulatory and clinical trial programs. The 108,590 units issued were measured by reference to their fair value on the issuance date, which is equal to CAD $14.76 per unit.

&nbsp;&nbsp;&nbsp;&nbsp;**8.** **Intangible assets** 

---

| |
|:---|
| **Cost** |
| Balance, December 31, 2023 |
| Additions |
| **Balance, December 31, 2024** |
| Additions |
| Disposal |
| **Balance, December 31, 2025** |

---

---

| | |
|:---|:---|
| **Accumulated amortization** | **Total** |
|  | **$** |
| Balance, December 31, 2023 | 161549 |
| Amortization | 31070 |
| **Balance, December 31, 2024** | **192619** |
| Amortization | 26385 |
| **Balance, December 31, 2025** | **219004** |

---

---

| | |
|:---|:---|
| **Carrying values** | **Total** |
|  | **$** |
| At December 31, 2024 | 183108 |
| **At December 31, 2025** | **185367** |

---

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**8.** **Intangible assets (continued)** 

The Company has licensed intellectual property from various third parties. The intangible assets relate solely to licensed intellectual property and there are no other classes of intangible assets. The intangible assets are as described below:

&nbsp;&nbsp;&nbsp;&nbsp;**a)** The Company has licensed from a third party (the "Licensor"), under patent rights purchase
agreement dated July 9, 2013 and amended April 15, 2014, certain patents relating to allopurinol for the treatment of hypertension. The
Company paid a total of $40,000 to the Licensor per the terms of the agreement.

The Company will also pay the Licensor royalties on the cumulative net revenues from the sale or sublicense of the product covered under the patent license until the later of (i) the expiration of the last patent right covering the product; and (ii) the expiration of ten years from the date of the first commercial sales of a product. As of December 31, 2025, no royalties have been accrued or paid.

&nbsp;&nbsp;&nbsp;&nbsp;**b)** In December 2012, the Company entered into an agreement to license certain intellectual property relating
to the use of all uric acid lowering agents to improve the treatment of metabolic syndrome. Under this patent rights purchase agreement,
between the Company and Dr. Richard Johnson and Dr. Takahiko Nakagawa (the "Vendors"), the Company will pay the Vendors a
royalty based on the cumulative net revenues from the sale or sublicense of the product covered under the licensed intellectual property
until the later of (i) the expiration of the last patent right covering the product; and (ii) the expiration of 10 years from the date
of the first commercial sales of a product. As of December 31, 2025, no royalties have been accrued or paid.

&nbsp;&nbsp;&nbsp;&nbsp;**c)** Pursuant to a license agreement dated October 9, 2012 as amended on June 23, 2014, between the Company
and the University of Florida Research Foundation, Inc. ("UFRF"), the Company acquired the exclusive license to a patent that
claims the use of any uric acid lowering agent to treat insulin resistance. The Company has paid or is obligated to pay UFRF the following:

&nbsp;&nbsp;&nbsp;&nbsp;i) An annual license fee of $1,000;

ii) Reimburse UFRF for United States and/or foreign costs associated with the maintenance of the licensed patents;

iii) The issuance to UFRF of 180,397 shares of common stock of the Company. 160,783 have been issued to UFRF as at December 31, 2025 and December 31, 2024. The remaining shares to be issued are included in obligation to issue shares ($24746);

iv) Milestone payments of $500,000 upon receipt of FDA approval to market licensed product in the United States of America and $100,000 upon receipt of regulatory approval to market each licensed product in each of other jurisdictions;

&nbsp;&nbsp;&nbsp;&nbsp;v) Royalty payments of up to 1.5% of net sales of products covered by the license until the later of (i)
the expiration of any patent claims; or (ii) 10 years from the date of the first commercial sale of any covered product in each country.
Following commencement of commercial sales, the Company will be subject to certain annual minimum royalty payments that will increase
annually to a maximum of $100,000 per year. As at December 31, 2025, no royalties have been accrued or paid; and

vi) UFRF is entitled to receive a royalty of 5% of amounts received from any sub-licensee that are not based directly on product sales, excluding payments received for research and development or purchases of the Company's securities at not less than fair market value. As at December 31, 2025, no royalties have been accrued or paid.

On October 12, 2025, UFRF terminated the agreement as the Company did not achieve the specified milestones. There were no outstanding financial obligations under the agreement at the termination date. Accordingly, the previously recognized license asset of $26,579 and the related obligation to issue shares of $24,746, which had been recorded within equity, were derecognized upon termination.

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**9.** **Property and equipment** 

---

| | | | |
|:---|:---|:---|:---|
| **Cost** | **Right-of-use <br> asset** | **Equipment** | **Total** |
|  | **$** | **$** | **$** |
| Balance, December 31, 2023 | 114588 | 23344 | 137932 |
| Additions | 96998 | - | 96998 |
| **Balance, December 31, 2024** | **211586** | **23344** | **234930** |
| Additions | 88074 | - | 88074 |
| **Balance, December 31, 2025** | **299660** | **23344** | **323004** |

---

---

| | | | |
|:---|:---|:---|:---|
| **Accumulated amortization** | **Right-of-use <br> asset** | **Equipment** | **Total** |
|  | **$** | **$** | **$** |
| Balance, December 31, 2023 | 103675 | 10330 | 114005 |
| Amortization | 78525 | 7679 | 86204 |
| **Balance, December 31, 2024** | **182200** | **18009** | **200209** |
| Amortization | 80763 | 4967 | 85730 |
| **Balance, December 31, 2025** | **262963** | **22976** | **285939** |

---

---

| | | | |
|:---|:---|:---|:---|
| **Carrying values** | **Right-of-use <br> asset** | **Equipment** | **Total** |
|  | **$** | **$** | **$** |
| At December 31, 2024 | 29386 | 5335 | 34721 |
| **At December 31, 2025** | **36697** | **368** | **37065** |

---

The Company entered into an office lease during the year ended December 31, 2022 for which a right-of-use asset was recognized (Note 11). During the year ended December 31, 2025, the Company extended its office lease. A $88,074 right-of-use asset addition was recognized with a corresponding $88,074 increase to the lease liability.

&nbsp;&nbsp;&nbsp;&nbsp;**10.** **Accounts payable and accrued liabilities** 

---

| | | |
|:---|:---|:---|
| | **December 31, <br> 2025** | **December 31, <br> 2024** |
|  | **$** | **$** |
| Trade payables | 395539 | 84020 |
| Accrued liabilities | 158245 | 63185 |
| Total | 553784 | 147205 |

---

&nbsp;&nbsp;&nbsp;&nbsp;**11.** **Lease obligation** 

The Company has entered into an office lease expiring in 2026, with an imputed interest rate of 8% per annum. A reconciliation of the outstanding lease obligation as at December 31, 2025 is as follows:

---

| |
|:---|
| Balance, December 31, 2023 |
| Additions |
| Lease payments) |
| Balance, December 31, 2024 |
| Additions |
| Lease payments) |
| **Balance, December 31, 2025** |

---

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**11.** **Lease obligation (continued)** 

The $88,074 lease obligation addition recognized in the year ended December 31, 2025 relates to an extension of the office lease to May 31, 2026. The $96,998 lease obligation recognized in the year ended December 31, 2024 relates to an extension of the office lease to May 31, 2025.

The following is a schedule of the Company's future minimum lease payments related to the office lease obligation:

---

| |
|:---|
| 2025 |
| 2026 |
| Total minimum lease payments |
| Less: imputed interest) |
| Total present value of minimum lease payments |
| Less: current portion) |
| Non-current portion |

---

&nbsp;&nbsp;&nbsp;&nbsp;**12.** **Share capital and reserves** 

&nbsp;&nbsp;&nbsp;&nbsp;**a)** **Authorized and issued** 

Unlimited common shares – 6,962,218 issued at December 31, 2025 (2024 – 3,481,375, 2023 – 1,998,848).

&nbsp;&nbsp;&nbsp;&nbsp;**b)** **Issuances** 

**Year ended December 31, 2025:**

On January 15, 2025, the Company issued 73,871 common shares in an at-the-market offering for gross proceeds of $113,547. In connection with the offering, the Company incurred issuance costs of $19,064. The costs were recorded as a reduction of equity.

On January 15, 2025, the Company issued 233,000 common shares for the exercise of pre-funded warrants at US$0.00001 per share in the amount of $2. An amount of $324,643 was transferred from reserves to share capital as a result.

On July 22, 2025, the Company closed a non-brokered private placement of 1,267,123 units at a price of $0.73 per unit for aggregate gross proceeds of $925,000. Each unit consists of one common share and one common share purchase warrant. Each warrant entitles the holder to purchase one common share at a price of $1.20 for a period of sixty months following the date of issuance provided, however, that if the closing price of the common shares on the Nasdaq is greater than $2.00 for ten or more consecutive trading days, the warrants will be accelerated and will expire on the 30th business day following the date of such notice. In connection with the offering, the Company paid an aggregate of $12,264 in finder's fees and issued, in aggregate, 16,800 finder's warrants. Each finder's warrant has terms equal to those of the common share purchase warrants. The Company incurred additional cash issuance costs of $305,604. The 16,800 finder's warrants were determined to have a fair value of $11,560.

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**12.** **Share capital and reserves (continued)** 

&nbsp;&nbsp;&nbsp;&nbsp;**b)** **Issuances (continued)** 

On August 8, 2025, the Company closed a non-brokered private placement of 156,849 units at a price of $0.73 per unit for aggregate gross proceeds of $114,500. Each unit consisted of one common share and one common share purchase warrant. Each warrant entitles the holder to purchase one common share at a price of $1.20 for a period of sixty months following the date of issuance provided, however, that if the closing price of the common shares on the Nasdaq is greater than $2.00 for ten or more consecutive trading days, the warrants will be accelerated and will expire on the 30th business day following the date of such notice. The Company incurred cash issuance costs of $32,075.

On October 23, 2025, the Company closed its registered direct offering for the purchase and sale of 572,470 common shares at a price of $0.63 per common share, and 1,177,530 pre-funded warrants at a price of $0.62999 per pre-funded warrant for aggregate gross proceeds of $1,102,488. Each pre-funded warrant entitles the holder to acquire one common share at an exercise price of $0.00001 per share. In connection with the offering, the Company paid an aggregate of $77,175 in finder's fees and issued 87,500 agent warrants, each exercisable into one common share of the Company at an exercise price of $0.69 commencing 181 days following issuances with a term of eighteen months from the closing date. The Company incurred additional cash issuance costs of $405,550 and were recorded as a reduction of equity. The 87,500 finder's warrants were determined to have a fair value of $26,924.

Concurrently with the closing of the offering, the Company issued 1,177,530 common shares for the exercise of the pre-funded warrants at $0.00001 per share in the amount of $12. An amount of $398,904 was transferred from reserves to share capital as a result.

**Year ended December 31, 2024:**

On February 15 and March 4, 2024, the Company closed two tranches of a non-brokered offering of 899,717 common share units at a price of CAD $3.00 per common share unit for aggregate gross proceeds of $2,000,549 (CAD $2,699,151). Each common share unit consists of one common share and one warrant to purchase one common share at CAD $4.50 per common share for a period of two years, provided, however that, if, the common shares on the TSXV trade at greater than CAD $6.00 for 10 or more consecutive trading days, the warrants will be accelerated and the warrants will expire on the 30th business day following the date of notice.

The proceeds were allocated $1,205,000 to the derivative warrant liability (Note 12(h)) and the residual $795,549 was allocated to common shares.

In connection with the offering, the Company paid finder's fees of $97,241, representing a 5% finder's fee on certain subscriptions to qualified finders. The Company incurred additional cash share issuance costs of $367,195 including $166,344 deferred at December 31, 2023. The costs were allocated between common shares and derivative warrant liability in proportion to their initial carrying amounts with $185,405 recorded as a reduction of equity and $279,031 recorded as transaction costs on derivative warrant liability.

On March 25, 2024, the Company issued 5,000 common shares for the exercise of warrants at CAD $4.50 per share in the amount of $16,570 (CAD $22,500). An amount of $5,244 was transferred from derivative warrant liability to share capital as a result.

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**12.** **Share capital and reserves (continued)** 

&nbsp;&nbsp;&nbsp;&nbsp;**b)** **Issuances (continued)** 

On October 18, 2024, the Company closed its registered direct offering and concurrent private placement for the purchase and sale of: (i) 320,000 common share units at a price of $1.85 per unit, with each unit consisting of one common share and one warrant to purchase one common share; and (ii) 490,810 pre-funded warrant units at a price of $1.84999 per pre-funded unit, with each pre-funded unit consisting of one pre-funded warrant to purchase one common share and one warrant to purchase one common share. Aggregate gross proceeds amounted to $1,499,993. The pre-funded warrants have an exercise price of $0.00001 per share and will terminate once exercised in full. The unit warrants are exercisable at an exercise price of $2.18 are immediately exercisable and expire five years from issuance.

In connection with the private placement, the Company incurred issuance costs of $370,276. The costs were recorded as a reduction of equity.

On November 21, 2024, the Company issued 257,810 common shares for the exercise of pre-funded warrants at US$0.00001 per share in the amount of $3. An amount of $359,211 was transferred from reserves to share capital as a result.

**Year ended December 31, 2023:**

On January 19, 2023, the Company issued 328,777 common shares for the exercise of pre-funded warrants at $0.0009 per share in the amount of $296. An amount of $531,885 was transferred from reserves to share capital as a result.

&nbsp;&nbsp;&nbsp;&nbsp;**c)** **Diluted Weighted Average Number of Common Shares Outstanding** 

---

| | | | |
|:---|:---|:---|:---|
|  | **Year ended** | **Year ended** | **Year ended** |
|  | **December 31, <br> 2025** | December 31, <br> 2024 | December 31, <br> 2023 |
| Basic weighted average shares outstanding | **4734633** | 2878514 | 1981734 |
| Effect of outstanding securities | - | - | - |
| Diluted weighted average shares outstanding | **4734633** | 2878514 | 1981734 |

---

During the years ended December 31, 2025, 2024 and 2023, the Company had a net loss, as such, the diluted loss per share calculation excludes any potential conversion of options and warrants that would decrease loss per share.

&nbsp;&nbsp;&nbsp;&nbsp;**d)** **Common Share Purchase Warrants** 

A summary of the changes in warrants for the years ended December 31, 2025, 2024 and 2023 is presented below:

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**12.** **Share capital and reserves (continued)** 

&nbsp;&nbsp;&nbsp;&nbsp;**d)** **Common Share Purchase Warrants (continued)** 

---

| | | |
|:---|:---|:---|
| | **Number of<br> Warrants**  | **Weighted<br> Average<br> Exercise price**  |
| **Balance, December 31, 2023 and 2022** | **1125210** | $**22.31** |
| Granted – February 9, 2024 | 824767 | 3.13<sup>(1)</sup> |
| Granted – February 23, 2024 | 74950 | 3.13<sup>(1)</sup> |
| Granted – October 18, 2024 | 810810 | 2.18 |
| Exercised | (5000) | 3.13<sup>(1)</sup> |
| **Balance, December 31, 2024** | **2830737** | $**3.60** |
| Granted – July 21, 2025 | 1267123 | 1.20 |
| Granted – August 8, 2025 | 156849 | 1.20 |
| **Balance, December 31, 2025** | **4254709** | $**2.82** |

---

<sup>(1)</sup> Exercise price of CAD $4.50.

During the year ended December 31, 2024, the Company amended the exercise price of 1,125,210 common share purchase warrants that were issued pursuant to private placements that closed in February 2021, October 2021 and October 2022. Pursuant to the polices of the TSXV the terms of the warrants, as amended, will be subject to an acceleration expiry provision such that if for any 10 consecutive trading dates during the unexpired term of the warrants, the closing price of the Company's shares on the exchange exceeds $6.50, the exercise period of the warrants will be reduced to 30 days, starting seven days after the last premium trading day. All other terms of the warrants remain unchanged.

At December 31, 2025, the weighted average contractual remaining life of the unexercised warrants was 2.58 years (2024 – 2.58 years).

The following table summarizes information on warrants outstanding at December 31, 2025:

---

| | | | |
|:---|:---|:---|:---|
| **Exercise Price** | **Number <br> Outstanding** | **Expiry date** | **Remaining <br> Contractual Life** |
| $5.00 | 198333<sup>(1)</sup> | February 9, 2026 | 0.11 years |
| $5.00 | 270211 | October 15, 2026 | 0.79 years |
| $5.00 | 101111 | October 15, 2026 | 0.79 years |
| $5.00 | 555555 | October 7, 2027 | 1.77 years |
| 4.50 | 819767<sup>(1)</sup> | February 9, 2026 | 0.11 years |
| 4.50 | 74950<sup>(1)</sup> | February 23, 2026 | 0.15 years |
| $2.18 | 810810 | October 18, 2029 | 3.80 years |
| $1.20 | 1267123 | July 21, 2030 | 4.56 years |
| $1.20 | 156849 | August 8, 2030 | 4.61 years |
| Total | 4254709 |  | 2.58 years |

---

<sup>(1)</sup> Expired unexercised subsequent to December 31, 2025.

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**12.** **Share capital and reserves (continued)** 

&nbsp;&nbsp;&nbsp;&nbsp;**e)** **Pre-Funded Warrants** 

A summary of the changes in pre-funded warrants for the years ended December 31, 2025, 2024 and 2023 is presented below:

---

| | | |
|:---|:---|:---|
| | **Number of<br> Warrants** | **Weighted<br> Average<br> Exercise price** |
| Balance, December 31, 2022 | 328777 | $0.0009 |
| Exercised | (328777) | 0.0009 |
| **Balance, December 31, 2023** | **-** | **-** |
| Granted – October 18, 2024 | 490810 | 0.00001 |
| Exercised | (257810) | 0.00001 |
| **Balance, December 31, 2024** | **233000** | $**0.00001** |
| Granted – October 23, 2025 | 1177530 | 0.00001 |
| Exercised | (1410530) | 0.00001 |
| **Balance, December 31, 2025** | **-** | **-** |

---

&nbsp;&nbsp;&nbsp;&nbsp;**f)** **Finders' and Underwriters Warrants** 

A summary of the changes in finders' and underwriters warrants for the years ended December 31, 2025, 2024 and 2023 is presented below:

---

| | | |
|:---|:---|:---|
| | **Number of<br> Warrants** | **Weighted<br> Average<br> Exercise price** |
| **Balance, December 31, 2024, 2023 and 2022** | **50298** | $**23.57** |
| Granted – July 21, 2025 | 16800 | 1.20 |
| Granted – October 23, 2025 | 87500 | 0.69 |
| **Balance, December 31, 2025** | **154598** | $**8.25** |
| **Exercisable, December 31, 2025** | **67098** | $**18.11** |

---

At December 31, 2025, the weighted average contractual remaining life of the unexercised finders' and underwriters' warrants was 1.64 years (2024 – 2.24 years).

<br> The following table summarizes information on finders' and underwriters' warrants outstanding at December 31, 2025:

---

| | | | |
|:---|:---|:---|:---|
| **Exercise Price** | **Number<br> Outstanding** | **Expiry date** | **Remaining<br> Contractual Life**  |
| 42.30 | 6377<sup>(1)</sup> | February 9, 2026 | 0.11 years |
| $42.93 | 16144 | October 15, 2026 | 0.79 years |
| $10.98 | 27777 | October 7, 2027 | 1.77 years |
| $1.20 | 16800 | July 21, 2030 | 4.56 years |
| $0.69 | 87500 | April 23, 2027 | 1.31 years |
| Total | 154598 |  | 1.64 years |

---

&nbsp;&nbsp;&nbsp;&nbsp;(1) Expired unexercised subsequent to December
 31, 2025.

The fair value of the finders' warrants issued on July 21, 2025 was estimated at $11,560 on the date of grant using the Black-Scholes option pricing model. The exercise price of the unit of $1.20; expected life of 5 years; expected volatility of 100%; risk free rate of 2.99%; and expected dividend yield of 0%.

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**12.** **Share capital and reserves (continued)** 

&nbsp;&nbsp;&nbsp;&nbsp;**f)** **Finders' and Underwriters Warrants (continued)** 

The fair value of the finders' warrants issued on October 23, 2025 was estimated at $26,924 on the date of grant using the Black-Scholes option pricing model. The exercise price of the unit of $0.69; expected life of 18 months; expected volatility of 87%; risk free rate of 2.39%; and expected dividend yield of 0%.

&nbsp;&nbsp;&nbsp;&nbsp;**g)** **Stock Options** 

The Company has an incentive Stock Option Plan (the "Plan") for directors, officers, employees, and consultants, under which the Company may issue stock options to purchase common shares of the Company provided that the amount of incentive stock options which may be granted and outstanding under the Plan at any time shall not exceed 10% of the then issued and outstanding common shares of the Company.

The weighted average fair value of stock options granted was estimated on the date of grant using the Black-Scholes option pricing model with the following data and assumptions:

---

| | | |
|:---|:---|:---|
|  | **2024** | **2023** |
| Dividend yield | Nil | Nil |
| Annualized volatility | 100% | 100% |
| Share price | CAD $3.82 | CAD $2.90 |
| Risk-free interest rate | 3.47% | 3.25% |
| Expected life | 5 years | 5 years |

---

The risk-free interest rate is the yield on zero-coupon Canadian Treasury Bills of a term consistent with the assumed option life. The expected life of the option is the average expected period to exercise.

Volatility is based on the available historical volatility of the Company's share price, excluding specific time frames in which volatility was affected by specific transactions that are not considered to be indicative of the Company's expected share price volatility. The Company has not declared dividends in the past.

During the year ended December 31, 2025, the Company recorded share-based expenses of $25,155 (2024 - $122,527; 2023 - $120,984), in respect of the vesting of options issued in prior years.

A summary of the changes in stock options for the years ended December 31, 2025, 2024 and 2023 is presented below:

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**12.** **Share capital and reserves (continued)** 

&nbsp;&nbsp;&nbsp;&nbsp;**g)** **Stock Options (continued)** 

---

| | | |
|:---|:---|:---|
| | **Number of<br> Options** | **Weighted<br> Average <br>Exercise<br> price (CAD)** |
| Balance, December 31, 2022 | 128240 | $21.75 |
| Granted – December 31, 2023 | 8000 | 2.90 |
| Expired | (32318) | 33.65 |
| **Balance, December 31, 2023** | **103922** | $**16.60** |
| Granted – March 4, 2024 | 39483 | 4.50 |
| Granted – April 8, 2024 | 8000 | 5.00 |
| Granted – December 18, 2024 | 13000 | 1.75 |
| Expired | (16642) | 22.22 |
| **Balance, December 31, 2024** | **147763** | $**10.80** |
| Expired | (18002) | 12.86 |
| **Balance, December 31, 2025** | **129761** | $**10.51** |
| **Vested and exercisable, December 31, 2025** | **109596** | $**11.86** |

---

The weighted average contractual remaining life of the unexercised options was 2.27 years (2024 - 3.02 years).

The following table summarizes information on stock options outstanding at December 31, 2025:

---

| | | | | |
|:---|:---|:---|:---|:---|
| **Exercise<br> Price (CAD$)**  | **Number<br> Outstanding**  | **Number <br>Exercisable** | **Expiry Date** | **Remaining<br> Contractual Life**  |
| 16.92 | 2366 | 2366 | May 12, 2026 | &nbsp;&nbsp;&nbsp;&nbsp;0.36 years |
| 21.69 | 4732 | 4732 | July 14, 2026 | &nbsp;&nbsp;&nbsp;&nbsp;0.53 years |
| 22.86 | 7262 | 7262 | December 21, 2026 | &nbsp;&nbsp;&nbsp;&nbsp;0.97 years |
| 22.86 | 9163 | 9163 | January 12, 2027 | &nbsp;&nbsp;&nbsp;&nbsp;1.03 years |
| 14.40 | 37200 | 37200 | June 6, 2027 | &nbsp;&nbsp;&nbsp;&nbsp;1.43 years |
| 12.42 | 5554 | 5554 | November 25, 2027 | &nbsp;&nbsp;&nbsp;&nbsp;1.90 years |
| 2.90 | 8000 | 8000 | December 31, 2028 | &nbsp;&nbsp;&nbsp;&nbsp;3.00 years |
| 4.50 | 34484 | 24069 | March 4, 2029 | &nbsp;&nbsp;&nbsp;&nbsp;3.18 years |
| 5.00 | 8000 | 8000 | April 8, 2029 | &nbsp;&nbsp;&nbsp;&nbsp;3.27 years |
| 1.75 | 13000 | 3250 | December 18, 2029 | &nbsp;&nbsp;&nbsp;&nbsp;3.97 years |
|  | **129761** | **109596** |  |  |

---

&nbsp;&nbsp;&nbsp;&nbsp;**h)** **Derivative Warrant Liability** 

During the years ended December 31, 2024, 2022 and 2021, the Company issued warrants which were recorded as derivative financial liabilities as the exercise price was denominated in a currency other than the functional currency of the Company and in certain situations allow the holder to exercise the warrants on a cashless basis and therefore may be settled other than by the exchange of a fixed amount of cash. Under the cashless exercise option, the holders of these warrants may elect to settle the warrants on a cashless basis if the common shares are not subject to an effective registration statement at the time the holder wishes to exercise them. A contract that may be settled by a single net payment (generally referred to as net cash settled or net equity settled) is a financial liability and not an equity instrument.

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**12.** **Share capital and reserves (continued)** 

&nbsp;&nbsp;&nbsp;&nbsp;**h)** **Derivative Warrant Liability (continued)** 

These warrants are revalued at each reporting period and any gain or loss is recorded in profit or loss.

The fair value of the warrants issued during the year ended December 31, 2025 with an exercise price denominated in CAD was estimated at $nil (2024 - $1,205,000) on the date of grant using the Black-Scholes option pricing model with the following data and assumptions:

---

| | |
|:---|:---|
|  | **2024** |
| Dividend yield | Nil |
| Annualized volatility | 130-135% |
| Share price | CAD$3.03 – CAD$3.40 |
| Risk-free interest rate | 4.28% – 4.33% |
| Expected life | 2 years |

---

**The balance of the derivative warrant liabilities (level 3) is as follows:**

---

| | |
|:---|:---|
| **Balance at December 31, 2022** | $**3854403** |
| Reclassified from reserves | 318000 |
| Fair value adjustment | (3641403) |
| **Balance at December 31, 2023** | $**531000** |
| Warrants issued February 9, 2024 | 1102000 |
| Warrants issued February 23, 2024 | 103000 |
| Warrants exercised | (5244) |
| Reclassified to reserves | (123651) |
| Fair value adjustment | (1035105) |
| **Balance at December 31, 2024** | $**572000** |
| Fair value adjustment | (564000) |
| **Balance at December 31, 2025** | $**8000** |

---

Significant assumptions used in determining the fair value of the derivative warrant liabilities at December 31, 2025, 2024 and 2023 are as follows:

---

| | | | |
|:---|:---|:---|:---|
| | **December 31, <br>2025** | **December 31, <br>2024** | **December 31, <br>2023** |
| Share price | $**0.56** | $**1.13** | $**2.31** |
| Risk-free interest rate | **2.55%** | **2.92%** | **3.25%-3.91%** |
| Dividend yield | **0%** | **0%** | **0%** |
| Expected volatility | **78%-127%** | **94%-134%** | **100%** |
| Remaining term (in years) | **0.1–1.8** | **1.1-2.8** | **2.1-3.8** |

---

The fair value is classified as level 3 as expected volatility is determined using historical volatility and is therefore not an observable input.

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**13.** **Related party transactions** 

All related party transactions were measured at fair value. All amounts due from/payable to related parties are unsecured, non-interest bearing and have no fixed terms of repayment.

During the year ended December 31, 2025, the Company incurred the following transactions with related parties:

&nbsp;&nbsp;&nbsp;&nbsp;a) Wages and benefits and professional fees were paid or accrued to Allen Davidoff, the Chief Executive Officer
("CEO"), in the amount of $324,738 (2024 - $391,655; 2023 - $337,794).

&nbsp;&nbsp;&nbsp;&nbsp;b) Fees were paid or accrued to Michael Bumby, the Chief Financial Officer ("CFO") of the Company
in the amount of $160,980 (2024 - $156,335 (paid or accrued to the former and current CFO; 2023 - $156,217 (paid or accrued to the former
CFO)).

&nbsp;&nbsp;&nbsp;&nbsp;c) Research and development fees were paid or accrued to Haworth Biopharmaceutical Consulting Services Inc.,
a company owned by Stephen Haworth, the Chief Medical Officer ("CMO") of the Company in the amount of $96,000 (2024 - $110,445;
2023 - $200,229).

&nbsp;&nbsp;&nbsp;&nbsp;d) Consulting fees were paid or accrued to Stacy Evans, the Chief Business Officer ("CBO") of
the Company in the amount of $150,000 (2024 - $157,500; 2023 - $280,000).

&nbsp;&nbsp;&nbsp;&nbsp;e) Directors' fees were paid or accrued to the directors of the Company in the amount of $215,568 (2024
- $172,229; 2023 - $182,675). The amount includes director fees payment of $128,877 for the year ended December 31, 2025 (2024 - $123,133;
2023 - $133,967) to Anthony Giovinazzo, Chairman of the Company.

&nbsp;&nbsp;&nbsp;&nbsp;f) As at December 31, 2025, $10,730 (2024 - $11,120) was payable to directors of the Company, $28,044 (2024
- $7,705) was payable and accrued to the CFO of the Company for CFO services, $16,000 (2024 - $8,000) was payable and accrued to the CMO
of the Company for consulting services, and $37,500 (2024 - $12,500) was payable and accrued to the CBO of the Company for consulting
services. The balances are unsecured, non-interest bearing, and have no fixed terms of repayment.

&nbsp;&nbsp;&nbsp;&nbsp;g) Management and directors' key management compensation transactions for the years ended December
31, 2025, 2024, and 2023 are summarized as follows:

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Management Compensation** | **Directors' <br>fees** | **Share-based payments** | **Total** |
|  | **$** | **$** | **$** | **$** |
| Year ended December 31, 2023 |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Directors and officers | 974240 | 182675 | 77779 | 1234694 |
| Year ended December 31, 2024 |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Directors and officers | 815935 | 172229 | 85680 | 1073845 |
| Year ended December 31, 2025 |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Directors and officers | **731718** | **215568** | **14559** | **961845** |

---

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**14.** **Income taxes** 

The income taxes shown in the consolidated statements of comprehensive loss differ from the amounts obtained by applying statutory rates to the loss before income taxes due to the following:

---

| | | | |
|:---|:---|:---|:---|
| | **2025** | **2024** | **2023** |
|  | **$** | **$** | **$** |
| Net loss for the year | (2656304) | (3313346) | (2158065) |
| Statutory tax rate | 27% | 27% | 27% |
| Expected income tax recovery | **(717000)** | **(895000)** | **(583000)** |
| Decrease to income tax recovery due to: |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Non-deductible permanent differences | (145000) | (246000) | 45000 |
| &nbsp;&nbsp;&nbsp;&nbsp;Temporary differences | (549000) | 312000 | (25000) |
| &nbsp;&nbsp;&nbsp;&nbsp;(Over) under provided in prior years |  | (1099000) | (559000) |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in tax assets not recognized | 1411000 | 1928000 | 1122000 |
| Income tax recovery | - | - | - |

---

The significant components of the Company's deferred tax assets are as follows:

---

| |
|:---|
| Share issuance costs |
| Cumulative eligible capital |
| Operating losses carried forward |
| Total deferred tax assets |
| Deferred tax assets not recognized) |

---

The realization of income tax benefits related to these deferred potential tax deductions is not probable. Accordingly, no deferred income tax assets have been recognized for accounting purposes. The Company has Canadian non-capital losses carried forward of approximately CAD $41,443,000 that may be available for tax purposes. The losses expire as follows:

---

| | |
|:---|:---|
| **Expiry date** | **CAD$** |
| 2032 | 44000 |
| 2033 | 748000 |
| 2034 | 325000 |
| 2035 | 286000 |
| 2036 | 365000 |
| 2037 | 618000 |
| 2038 | 1089000 |
| 2039 | 554000 |
| 2040 | 1116000 |
| 2041 | 3648000 |
| 2042 | 12628000 |
| 2043 | 8084000 |
| 2044 | 6534000 |
| 2045 | 5404000 |
| Total | 41443000 |

---

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**15.** **Financial instruments and risk management** 

The Company's financial instruments consist of cash, accounts receivable, contract payments, accounts payable and accrued liabilities, lease obligation and derivative warrant liability. The fair values of cash and accounts payable and accrued liabilities and lease liability approximate their carrying values at December 31, 2025, due to their short-term nature. Derivative warrant liability is carried at fair value and is classified within Level 3 of the fair value hierarchy.

The following table presents the Company's financial instruments, measured at fair value on the consolidated statements of financial position as at December 31, 2025 and 2024 and categorized into levels of the fair value hierarchy:

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | | **December 31, 2025** | **December 31, 2024** | **December 31, 2024** | **December 31, 2024** |
| | Level | **Carrying<br> Value**  | | **Carrying<br> Value**  | **Estimated<br> Fair Value**  |
|  |  | **$** | $— | **$** | **$** |
| **FVTPL** |  |  |  |  |  |
| Derivative warrant liability | 3 | 8000 |  | 572000 | 572000 |

---

There were no transfers for levels of change in the fair value measurements of financial instruments for the years ended December 31, 2025, 2024 and 2023.

Risk management is carried out by the Company's management team with guidance from the Board of Directors. The Company's risk exposures and their impact on the Company's financial instruments were as follows:

&nbsp;&nbsp;&nbsp;&nbsp;**a)** **Credit risk** 

Credit risk is the risk of financial loss to the Company if a customer of counterparty to a financial instrument fails to meet its obligations. The Company's maximum exposure to credit risk at the financial position date under its financial instruments is summarized as follows:

---

| | | |
|:---|:---|:---|
| | **December 31,<br> 2025**  | **December 31,<br> 2024**  |
|  | **$** | **$** |
| **Cash** | 864514 | 2473649 |

---

All of the Company's cash is held with major financial institutions in Canada and management believes the exposure to credit risk with such institutions is minimal. The Company considers the risk of material loss to be significantly mitigated due to the financial strength of the major financial institutions where cash is held. The Company has no exposure to the ongoing banking crisis. The Company's maximum exposure to credit risk as at December 31, 2025 and 2024 is the carrying value of its financial assets.

&nbsp;&nbsp;&nbsp;&nbsp;**b)** **Liquidity risk** 

Liquidity risk is the risk that the Company will not be able to meet its obligations associated with financial liabilities. The Company has a planning and budgeting process in place by which it anticipates and determines the funds required to support normal operation requirements as well as the growth and development of its intellectual property portfolio.

The Company's financial assets are comprised of its cash, accounts receivable, contract payments and the financial liabilities are comprised of its accounts payable and accrued liabilities, and lease liability.

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**15.** **Financial instruments and risk management (continued)** 

The contractual maturities of these financial liabilities as at December 31, 2025 and 2024 are summarized below:

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Payments due by period as of December 31, 2025** | **Payments due by period as of December 31, 2025** | **Payments due by period as of December 31, 2025** | **Payments due by period as of December 31, 2025** |
| | **Total** | **Less than 3 months** | **Between 3 months and 1 year** | **1-3 years** |
|  | **$** | **$** | **$** | **$** |
| Accounts payable and accrued liabilities | 553784 | 553784 |  |  |
| Lease liability | 37287 | 22230 | 15057 | - |
|  | 591071 | 576014 | 15057 | - |

---

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Payments due by period as of December 31, 2024** | **Payments due by period as of December 31, 2024** | **Payments due by period as of December 31, 2024** | **Payments due by period as of December 31, 2024** |
| | **Total** | **Less than 3 months** | **Between 3 months and 1 year** | **1-3 years** |
|  | **$** | **$** | **$** | **$** |
| Accounts payable and accrued liabilities | 147205 | 147205 |  |  |
| Lease liability | 38785 | 23124 | 15661 | - |
|  | 185990 | 170329 | 15661 | - |

---

&nbsp;&nbsp;&nbsp;&nbsp;**c)** **Market risk** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;i) Interest Rate Risk

Interest rate risk is the risk that the fair value of future cash flows of a financial instrument will fluctuate due to changes in market interest rates. The Company's bank accounts bear interest. Management believes that the credit risk concentration with respect to financial instruments included in cash is minimal.

ii) Foreign Currency Risk

As at December 31, 2025, the Company is exposed to currency risk on the following financial assets and liabilities denominated in Canadian Dollars ("CAD"). The sensitivity of the Company's net earnings due to changes in the exchange rate between the CAD against the U.S. dollar is included in the table below in U.S. dollar equivalents:

---

| |
|:---|
| Cash |
| Accounts payable and accrued liabilities |
| **Net exposure** |
| **Effect of +/- 10% change in currency** |

---

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**15.** **Financial instruments and risk management (continued)** 

The Company thoroughly examines the various financial instruments and risks to which it is exposed and assesses the impact and likelihood of those risks. These risks include foreign currency risk, interest rate risk, market risk, credit risk, and liquidity risk. Where material, these risks are reviewed and monitored by the Board of Directors

There have been no changes in any risk management policies since December 31, 2024.

&nbsp;&nbsp;&nbsp;&nbsp;**16.** **Capital management** 

The Company defines capital that it manages as shareholders' equity. The Company manages its capital structure in order to have funds available to support its research and development and sustain the future development of the business. When managing capital, the Company's objective is to ensure the entity continues as a going concern as well as to maintain optimal returns to shareholders and benefits for other stakeholders. Management adjusts the capital structure as necessary in order to support its activities.

Since inception, the Company's objective in managing capital is to ensure sufficient liquidity to finance its research and development activities, general and administrative expenses, expenses associated with intellectual property protection, and its overall capital expenditures. There were no changes during the year ended December 31, 2025. The Company is not exposed to external requirements by regulatory agencies regarding its capital.

&nbsp;&nbsp;&nbsp;&nbsp;**17.** **Commitments** 

The Company has long-term arrangements with commitments that are not recognized as liabilities as at December 31, 2025 and December 31, 2024 are as follows:

&nbsp;&nbsp;&nbsp;&nbsp;**a)** **Employment Agreements** 

---

| | | |
|:---|:---|:---|
| | **December 31, <br>2025** | **December 31, <br>2024** |
|  | **$** | **$** |
| Management services – officers | 321000 | 321000 |

---

The President, CEO, and a director of the Company has a long-term employment agreement with the Company. The agreement has a termination clause whereby he is entitled to the equivalent of 12 times his then current monthly salary which, as of December 31, 2025 and 2024, equated to an annual salary of $321,000.

&nbsp;&nbsp;&nbsp;&nbsp;**b)** **Payments** 

In the normal course of business, the Company has committed to payments totaling $131,199 (December 31, 2024 - $323,000) related to its clinical trial, and manufacturing, activities, and other regular business activities excluding management and director compensation which are expected to occur over the next 12 months.

&nbsp;&nbsp;&nbsp;&nbsp;**18.** **Segmented information** 

The Company operates in one reportable operating segment: the development and commercialization of therapies to treat hyperuricemia related diseases. As the operations comprise a single reporting segment, amounts disclosed also represent segment amounts. All long-term assets of the Company are located in Canada.

**XORTX THERAPEUTICS INC.**

**Notes to the Consolidated Financial Statements**

**For the years ended December 31, 2025, 2024 and 2023**

**(Expressed in U.S. Dollars)**

&nbsp;&nbsp;&nbsp;&nbsp;**19.** **Subsequent event** 

On October 15, 2025, the Company entered into a binding term sheet (the "Term Sheet") to acquire a Renal Anti-Fibrotic Therapeutic Program from Vectus Biosystems Limited, an Australian Securities Exchange listed company ("Vectus"). The program includes a novel new chemical entity, VB4-P5, along with its associated intellectual property, regulatory documentation, and manufacturing data. The Term Sheet provides for the Company to acquire from Vectus the intellectual property specifically related to the VB4-P5 compound and the data generated by Vectus from its work on the VB4-P5 small molecule and related assets. The consideration receivable by Vectus is $3,000,000, payable in common shares of the Company at a deemed issue price of $0.86 per common share (the "Issue Price"), with the Issue Price subject to adjustment in certain circumstances. The Company has agreed to pay a cash finders' fee of the greater of 5% of the transaction value or $250,000.

The Term Sheet is subject to finalization of closing documentation, satisfaction of conditions that are typical for a transaction of this type including receipt of all regulatory approvals, and compliance with applicable stock exchange requirements and applicable securities laws. Closing of the acquisition will occur no more than 90 days from the execution of the Term Sheet. If the Term Sheet is terminated or closing does not occur, other than as a result of a breach of the Term Sheet by Vectus, then the Company shall issue to Vectus $50,000 of common shares at the Issue Price.

Pursuant to the binding term sheet that was entered into between XORTX and Vectus, closing is to occur no later than 90 days post signing, being January 13, 2026.

On January 13, 2026, the Company entered into an extension agreement with Vectus to extend the closing date to March 31, 2026.

As of December 31, 2025, the Company had incurred $293,803 of deferred acquisition costs in connection with this transaction, which includes $200,000 towards the finders' fee.

On February 4, 2026, the Company issued 20,000 options to purchase common shares of the Company to a director. The options are exercisable at a price of CAD $0.69 per common share and expire five years from the date of grant.

## Exhibit 99.2

#### Exhibit 99.2

#### XORTX THERAPEUTICS INC.

#### Management Discussion and Analysis

#### For the year ended December 31, 2025
This management discussion and analysis of financial position and results of operations **("MD&A"**) is prepared as at February 25, 2026 and should be read in conjunction with the audited consolidated financial statements and related notes thereto of XORTX Therapeutics Inc. (the **"Company"** or **"XORTX"**) for the year ended December 31, 2025, which have been prepared in accordance with IFRS Accounting Standards (**"IFRS"**) as issued by the International Accounting Standards Board (**"IASB"**) and interpretations of the International Financial Reporting Interpretations Committee (**"IFRIC"**). All dollar figures in this MD&A are expressed in US dollars unless stated otherwise.

In this discussion, unless the context requires otherwise, references to "we" or "our" are references to XORTX Therapeutics Inc.

#### CORPORATE INFORMATION
XORTX was incorporated under the laws of Alberta, Canada on August 24, 2012, under the name ReVasCor Inc. and continued under the Canada Business Corporations Act on February 27, 2013, under the name of XORTX Pharma Corp. Upon completion of a reverse take-over transaction on January 10, 2018, with APAC Resources Inc., a company incorporated under the laws of British Columbia, the Company changed its name to "XORTX Therapeutics Inc." and XORTX Pharma Corp. became a wholly-owned subsidiary. The Company's operations and mailing address is 3710 – 33<sup>rd</sup> Street NW, Calgary, Alberta, Canada T2L 2M1 and its registered address is located at 250 Howe Street, 20<sup>th</sup> Floor, Vancouver, British Columbia, V6C 3R8. The Company's shares trade on the TSX Venture Exchange ("**TSXV**") and on the Nasdaq Stock Exchange ("**Nasdaq**") under the symbol "XRTX", and on the Börse Frankfurt under the symbol "ANU".

#### FORWARD LOOKING STATEMENTS
This MD&A contains certain statements, other than statements of historical fact that are forward-looking statements, which reflect the current view of the Company with respect to future events including corporate developments, financial performance and general economic conditions which may affect the Company.

All statements other than statements of historical fact contained in this MD&A, including statements regarding our strategy, future operations, future financial position, future revenue, projected costs, prospects, plans, objectives of management and expected market growth are forward-looking statements. These statements involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements.

The words "anticipate," "believe," "could," "estimate," "expect," "intend," "may," "plan," "potential," "predict," "project," "should," "target," "will," "would" and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. These forward- looking statements include, among other things, statements about:

· our ability to obtain additional financing;

· the accuracy of our estimates regarding expenses, costs associated with clinical trials, regulatory and
commercial activities, future revenues and capital requirements;

· the success and timing of our preclinical studies and clinical trials;

· our ability to obtain and maintain regulatory approval of " XORLO<sup>TM</sup>" ,
XORTX's proprietary formulation of oxypurinol for use in the Company's XRx-026 program to treat gout, and alternative proprietary
formulations of oxypurinol for its XRx-008 program to treat ADPKD, and any other product candidates we may develop, and the labeling
under any approval we may obtain;

· regulatory approvals and other regulatory developments in the United States and other countries;

· the performance of third-party manufacturers and contract research organizations;

![](logo.jpg)<sub>1</sub>

· our plans to develop and commercialize our product candidates;

· our plans to advance research in other kidney disease applications;

· our ability to obtain and maintain intellectual property protection for our product candidates;

· the successful development of our sales and marketing capabilities;

· the potential markets for our product candidates and our ability to serve those markets;

· the rate and degree of market acceptance of any future products;

· the success of competing drugs that are or become available; and

· the loss of key scientific or management personnel.

XORTX relies on certain key expectations and assumptions in making the forecasts, projections, predictions or estimations set out in forward-looking information. These factors and assumptions are based on information available at the time that the forward-looking information is provided. These include, but are not limited to, expectations and assumptions concerning:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· the availability of capital on acceptable terms to fund planned expenditures;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· prevailing regulatory, tax and environmental laws and regulations; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· the ability to secure necessary personnel, equipment and services.

Undue reliance should not be placed on forward-looking information because a number of risks and factors may cause actual results to differ materially from those set out in such forward-looking information. These include:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· the availability of capital on acceptable terms;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· incorrect assessments of the value of acquisitions, licenses and development programs;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· technical, manufacturing and processing problems;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· actions by governmental authorities, including increases in taxes and tariffs;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· fluctuations in foreign exchange, currency, or interest rates and stock market volatility;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· failure to realize the anticipated benefits from licenses or acquisitions;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· the other factors specifically identified as risk factors in this MD&A; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· potential labour unrest.

Readers are cautioned that the foregoing list of factors should not be construed as exhaustive. Further information relating to risks is included in this MD&A under Risks Related to the Business.

Except as may be required by applicable law or stock exchange regulation, XORTX undertakes no obligation to update publicly or release any revisions to these forward-looking statements to reflect events or circumstances after the date of this document or to reflect the occurrence of unanticipated events. Accordingly, readers should not place undue reliance on forward-looking statements. If XORTX does update one or more forward-looking statements, no inference should be drawn that additional updates will be made with respect to those or other forward-looking statements. Additional information relating to the Company is available by accessing the SEDAR+ website at www.sedarplus.ca.

#### BUSINESS OVERVIEW
XORTX is a late-stage clinical pharmaceutical company, focused on developing and potentially commercializing innovative therapies to treat diseases modulated by aberrant purine and uric acid metabolism in indications such as gout, autosomal dominant polycystic kidney disease ("**ADPKD**"), an orphan (rare) disease, Fibrotic Kidney disease and larger, more prevalent type 2 diabetic nephropathy ("**T2DN**"), as well as acute kidney injury ("**AKI**") associated with respiratory virus infection.

Our focus is on developing unique therapeutic products to:

1/ treat gout patients, specifically those that have shown an intolerance to treatment with allopurinol;

2/ slow or reverse the progression of chronic kidney disease in patients at risk of end stage kidney failure;

3/ address the immediate need of individuals facing AKI associated with respiratory virus infection;

4/ treat and slow the deposition of fibrosis in the kidney in the setting of progressive kidney disease; and

5/ identify other opportunities where our existing and new intellectual property can be leveraged to address health issues.

![](logo.jpg)<sub>2</sub>

We believe that our technology is underpinned by well-established research and insights into the underlying biology of aberrant purine metabolism, chronically high serum uric acid and its health consequences. Our aim is to advance a novel proprietary formulation of oxypurinol, a uric acid lowering agent that works by effectively inhibiting xanthine oxidase. We are developing product candidates that include new or existing drugs that can be adapted to address disease indications where aberrant purine metabolism and/or elevated uric acid is a common denominator, including gout, polycystic kidney disease, pre-diabetes, insulin resistance, metabolic syndrome, diabetes, diabetic nephropathy, and infection. We are focused on building a pipeline of assets to address the unmet medical needs of patients with a variety of serious or life-threatening diseases using our innovative formulation of oxypurinol, and in combination with uric acid lowering agents - a pipeline-in-a-product strategy supported by our intellectual property, established exclusive manufacturing agreements, and proposed clinical trials with experienced clinicians.

Our four current unique product development programs are:

· **XRx-026**, a program for the treatment of gout;

· **XRx-008**, a program for the treatment of ADPKD;

· **XRx-101**, a program to treat AKI associated with respiratory virus infection and associated health
consequences;

· **VB4** -P5, a program to treat and prevent fibrosis in the kidney in rare kidney disease; and

· **XRx-225**, a program for the treatment of T2DN.

At XORTX, we aim to develop medications to improve the quality of life of patients with life threatening diseases by modulating aberrant purine, fibrosis and uric acid metabolism.

#### Our Proprietary Therapeutic Platforms
Our expertise and understanding of the pathological effects of aberrant purine metabolism combined with our understanding of uric acid lowering agent structure and function, has enabled the development of our proprietary therapeutic platforms. These are a complementary suite of therapeutic formulations and new chemical entities designed to provide unique solutions for acute and chronic disease. Our therapeutic platforms can be used alone, or in combination, with synergistic activity for a tailored approach to a variety of indications. We continue to leverage these therapeutic platforms to expand our pipeline of novel and next generation drug-based product candidates. We believe these could represent significant improvements to the standard of care in multiple acute and chronic cardiovascular and renal diseases.

We believe our in-house drug design and formulation capabilities confer a competitive advantage to our therapeutic platforms. Some of these key advantages are:

**Highly Modular and Customizable**

Our platforms can be combined in multiple ways and this synergy can be applied to address acute, intermittent or chronic disease progression. For example, our XRx-026 and XRx-008 programs are designed for longer term stable chronic oral dosing of xanthine oxidase inhibitors ("**XOI**"). We believe that our formulation technology allows us to manage the unique challenges of cardiovascular and renal disease by modulating purine metabolism and its negative health consequences on the body. Our XRx-101 program for AKI associated with respiratory virus infection is designed to produce rapid suppression of hyperuricemia and then maintain purine metabolism at a low level during viral infection and target management of acute organ injury.

#### Fit-for-purpose
Our platforms can be utilized to engineer new chemical entities and formulations of those agents that have enhanced properties. For example, our XRx-225 product candidate program represents a potential new class of xanthine oxidase inhibitor(s) with a design that enhances their anti-inﬂammatory activity. The capability of tailoring the potential therapeutic benefit of this class of new agents permits us to identify targets and diseases that may respond to treatment. Additionally, the recent agreement to acquire the VB4-P5 molecule will permit the development of a novel new chemical entity, that potently decreases the rate of fibrosis, for the unmet medical need in kidney disease. Through rational design, we can further optimize proprietary formulations to maximize their clinical potential and importantly their therapeutic effects, while minimizing their side effect profile.

![](logo.jpg)<sub>3</sub>

#### Readily Scalable and Transferable
Our in-house small molecule and formulations design expertise can create a steady succession of drug product candidates that are scalable, efficient to manufacture and produce large scale, high purity active pharmaceutical drug product. We believe this will provide a competitive advantage, new intellectual property and the opportunity to provide first-in-class products that target unmet medical needs and meaningful improvements to quality of life.

Our team's expertise in uric acid lowering agents, speciﬁcally in the development and use of xanthine oxidase inhibitors, has enabled the development of our therapeutic product candidates to treat the symptoms of, and potentially delay the progression of gout, ADPKD, kidney fibrosis, and AKI associated with respiratory virus infection, and T2DN.

#### Product Candidate Pipeline
Our product candidates include XRx-026, XRx-008, XRx-101, VB4-P5 and XRx-225. Our lead program, XRx-026 is designed to treat gout. This program has recently been elevated in status as it represents a near-term opportunity for marketing approval and revenue generation. The Company believes that this program has sufficiently advanced through required chemistry, manufacturing pharmacology, toxicology and clinical studies, and needs only a pharmacokinetics trial with commercial drug, prior to a NDA filing. Ongoing discussions with the FDA in preparation for an NDA submission to gain market approval through the Section 505(b)(2) regulatory pathway are underway.

The Company's second program, XRx-008 for the treatment of ADPKD, has reported topline results for the XRX-OXY-101 Bridging Pharmacokinetic Study of XORLO<sup>TM</sup> (the "**XRX-OXY-101 PK Clinical Trial**") in advance of initiating Phase 3 registration clinical trial testing, the last stage of clinical development before application for FDA approval. Discussions with the FDA have confirmed that a single clinical trial with a one-year treatment period would be sufficient to make this program eligible for accelerated approval, once the benefit of XORLO<sup>TM</sup> on decreasing the rate of decline of glomerular filtration rate has been demonstrated.

Our completed and reported bridging pharmacokinetics study XRX-OXY-101 supports the XRx-026, XRx-008 and XRx-101 programs. Future late-stage clinical studies targeting attenuation or reversal of AKI in hospitalized individuals with respiratory virus infection are planned. XRx-225 is a non-clinical stage program advancing new chemical entities toward the clinical development stage for the treatment of T2DN. VB4-P5 is a new chemical entity at the non-clinical stage of development.

#### Products
With respect to the Company's lead and most advanced development program, XRx-026, the FDA has provided responses to the Company's Type B Meeting Package clarifying the remaining steps needed for submission of an NDA through the Section 505(b)(2) regulatory pathway for the treatment of gout. XORTX intends to advance this drug to marketing approval pending its FDA discussions. The Company believes that peak net sales revenue for this product could reach more than $500 million USD per year.

XRx-008 is XORTX's late clinical stage program focused on demonstrating the potential of its novel product candidate for ADPKD. XRx-008 is the development name given to XORTX's therapeutics program and associated proprietary oral formulation of oxypurinol, appropriate for use in individuals with progressively decreasing kidney filtering capacity.

![](logo.jpg)<sub>4</sub>

XORTX is also developing a drug product combination therapy that includes both intravenous uric acid lowering therapy combined with an oral anti-hyperuricemic xanthine oxidase inhibitor, XRx-101, for use in treating patients with AKI associated with respiratory virus infection and/or associated co-morbidities including sepsis.

XORTX is currently evaluating novel XOI candidates for its XRx-225 program to treat T2DN as well as developing new chemical entities to address other orphan and large market disease patients with unmet medical needs.

XORTX has initiated the acquisition of VB4-P5, an early-stage new chemical entity that potently decreases fibrosis in the kidney in an animal model of kidney disease.

#### Patents
XORTX is the exclusive licensee of two U.S. granted patents with claims to the use of all uric acid lowering agents to treat insulin resistance and diabetic nephropathy. Counterparts for some of these patent applications have also been submitted in Europe. In both the US and Europe, XORTX wholly owns composition of matter patents and patent applications for unique proprietary formulations of xanthine oxidase inhibitors. To date three patents have been granted: one in the U.S. and two in Europe. In addition, XORTX has submitted two patent applications to cover the use of uric acid lowering agents for the treatment of the health consequences of respiratory virus infection. Recently, XORTX filed a third provisional patent application covering formulations and methods of dosing xanthine oxidase inhibitors in individuals with kidney disease. The VB4-P5 acquisition adds granted worldwide patents for composition and use of this anti-fibrotic agent.

#### OUR STRATEGY
The Company's goal is to apply our interdisciplinary expertise and pipeline-in-a-product strategy to further identify, develop and commercialize novel treatments for rare/orphan and broader indications related to health consequences associated with gout patients, progressive kidney disease and the health consequences of diabetes. To achieve this objective, we intend to pursue the following strategies:

1. Subject to ongoing discussions with US Food and Drug Administration (the "FDA"), file an Investigational
New Drug application (an "IND"), prepare commercial supply of drug substance and drug product, conduct a bridging pharmacokinetics
study with commercial supply of tablets and then submit a New Drug Application (a "NDA") to the FDA, for the XRx-026 product
candidate program, which we believe will address an unmet medical need for gout.

2. Subject to discussions with the FDA, following the successful completion of a Phase 3 clinical registration
trial of the XRx-008 product candidate program submit a NDA to the FDA, requesting review under the Accelerated Approval status. We believe
the introduction of this class of drug could establish a new standard of care for ADPKD.

3. Maximize the potential of the XRx-026 and XRx-008 product candidate programs, if approved, through independent
commercialization and/or through opportunistic collaborations with third parties.

4. Leverage our pipeline-in-a-product strategy and experience, developing additional
proprietary formulations of xanthine oxidase inhibitor and/or uric acid lowering agents to treat select disease indications, and complement
our activities through acquisitions and/or in-licensing opportunities in nephrology and diabetes when opportunities arise.

Our ability to implement our business strategy is subject to numerous risks. These risks include, among others (see "Risks Related to the Business"):

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· we will require substantial additional funding, which may not be available to us on acceptable terms,
or at all, and, if not available, may require us to alter, delay, scale back, or cease our product development programs or operations;

![](logo.jpg)<sub>5</sub>

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· we have incurred significant losses since inception and anticipate that we will continue to incur losses
for the foreseeable future;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· we have a limited number of product candidates, all of which are still in various stages of development,
and we may fail to obtain regulatory approval or experience significant delays in doing so;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· our product candidates may have undesirable side effects that may delay or prevent marketing approval
or, if approved, require them to be taken off the market, require them to include contraindications, warnings and precautions, limitations
of use, or otherwise limit their sales;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· we may be unable to obtain regulatory approval for our product candidates under applicable regulatory
requirements, and the denial or delay of any such approval would delay commercialization of our product candidates, if approved, and adversely
impact our potential to generate revenue, our business and our results of operations;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· security breaches, loss of data and other disruptions could compromise sensitive information related to
our business or protected health information or prevent us from accessing critical information and expose us to liability, which could
adversely affect our business and our reputation;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· our existing strategic partnerships are important to our business, and future strategic partnerships may
also be important to us; if we are unable to maintain any of these strategic partnerships, or if these strategic partnerships are not
successful, we may not realize the anticipated benefits of our strategic partnerships and our business could be adversely affected;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· we rely on third parties to monitor, support, conduct and oversee clinical trials of the product candidates
that we are developing and, in some cases, to maintain regulatory files for those product candidates;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· our commercial success depends significantly on our ability to operate without infringing the patents
and other proprietary rights of third parties and a third party could allege that the commercialization of one of our products infringes
upon their intellectual property in some way;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· our patents covering one or more of our products or product candidates could be found invalid or unenforceable
if challenged;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· if we are unable to obtain, maintain and enforce patent and trade secret protection for our product candidates and related technology,
our business could be materially harmed; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· if we are unable to protect the confidentiality of our proprietary information, the value of our technology
and products could be adversely affected.

#### Funding Requirements
The Company has not generated any revenue from product sales to date and does not expect to do so until such time as XORTX obtains regulatory approval for and commercializes one or more of our product candidates. As the Company's development programs are currently in various stages of development, it will be some time before we expect to achieve commercialization of one or more of our products and it is uncertain that we ever will. We expect that we will continue to increase our operating expenses in connection with clinical and preclinical activities and the development of product candidates in our pipeline. We also expect to continue to seek strategic partnerships and additional collaboration opportunities. Further, we expect to continue our efforts to pursue additional grants and refundable tax credits from the Canadian government in order to further our research and development efforts. Although it is difficult to predict our funding requirements, based upon our current operating plan, the Company anticipates that our existing cash and cash equivalents as of December 31, 2025, combined with the net proceeds of future financings, will enable us to advance the development of the XRx-026 and XRx-008 product candidates. XRx-026 is the Company's focus near term and will be advanced subject to available funds. The XRx-008, XRx-101, VB4-P5 and XRx-225 programs will be advanced when sufficient additional funding is available. A small portion of the Company's resources will be allocated to intellectual property development. XORTX may also be eligible to receive certain research, development, and commercial milestone payments in the future. However, because the successful development of our product candidates and the achievement of milestones by our strategic partners are uncertain, we are unable to estimate the actual funds required to complete the research, development, and commercialization of our product candidates.

![](logo.jpg)<sub>6</sub>

#### RECENT DEVELOPMENTS
**Financing Activities**

On January 15, 2025, the Company issued 73,871 common shares in an at-the-market offering for gross proceeds of $113,547.

On July 22, 2025, the Company closed a non-brokered private placement of 1,267,123 units at a price of $0.73 per unit for aggregate gross proceeds of $925,000. Each Unit consisted of one common share in the capital of the Company and one common share purchase warrant. Each warrant entitles the holder thereof to purchase one additional common share at a price of $1.20 for a period of five years following the date of issuance provided, however, that if the closing price of the common shares on the Nasdaq is greater than $2.00 for 10 or more consecutive trading days, the warrants will be accelerated and will expire on the 30<sup>th</sup> day following the date of such notice. In connection with the Offering, the Company paid an aggregate of $12,264 in finder's fees and issued, in aggregate, 16,800 finder's warrants.

On August 8, 2025, the Company closed a non-brokered private placement of 156,849 units at a price of $0.73 per unit for aggregate gross proceeds of $114,500. Each unit consisted of one common share in the capital of the Company and one common share purchase warrant. Each warrant entitles the holder thereof to purchase one additional common share at a price of $1.20 for a period of five years following the date of issuance provided, however, that if the closing price of the common shares on the Nasdaq is greater than $2.00 for 10 or more consecutive trading days, the warrants will be accelerated and will expire on the 30<sup>th</sup> day following the date of such notice. The Company incurred cash issuance costs of $32,075.

On October 23, 2025, the Company closed its registered direct offering (the "Offering") for the purchase and sale of 572,470 common shares at a price of $0.63 per common share, and 1,177,530 pre-funded warrants at a price of $0.62999 per pre-funded warrant for aggregate gross proceeds of $1,102,488. Each pre-funded Warrant will entitle the holder to acquire one common share at an exercise price of $0.00001 per share. D. Boral Capital LLC acted as sole placement agent for the Offering and was paid $77,175 in finder's fees and issued 87,500 agent warrants exercisable into one common share of the Company at an exercise price of $0.69 per common share commencing 181 days following issuance and expiring 18 months from the closing date.

**Corporate Advancements**

On October 17, 2025, the Company announced that it had entered into a binding term sheet (the "Term Sheet") to acquire a Renal Anti-Fibrotic Therapeutic Program from Vectus Biosystems Limited, an Australian Securities Exchange listed company ("Vectus"). The program includes a novel new chemical entity, VB4-P5, along with its associated intellectual property, regulatory documentation, and manufacturing data. The program is currently at the pre-IND stage of development and targets both rare and prevalent forms of kidney disease — areas with substantial unmet medical need. The Term Sheet provides for the Company to acquire from Vectus the intellectual property specifically related to the VB4-P5 compound and the data generated by Vectus from its work on the VB4-P5 small molecule and related assets. The consideration receivable by Vectus is $3.0 million, payable in common shares or common share equivalents of the Company at a deemed issue price of $0.86 per Security (the "Issue Price"), with the Issue Price subject to adjustment in certain circumstances provided, however, that the Issue Price will not be lower than the Discounted Market Price (as defined in the policies of the TSXV) on the last trading day prior to the announcement of this transaction.

The Term Sheet is subject to finalization of closing documentation, satisfaction of conditions that are typical for a transaction of this type including receipt of all regulatory approvals, and compliance with applicable stock exchange requirements and applicable securities laws. Closing of the acquisition will occur no more than 90 days from the execution of the Term Sheet. If requested by Vectus, the Company will use its reasonable commercial efforts to register the Securities with the Securities and Exchange Commission of the United States. In addition, Vectus will enter into a voluntary lockup agreement that, among other things, restricts sales of the Securities by Vectus for 180 days after the Closing Date. If the Term Sheet is terminated or if closing does not occur, XORTX will be required to issue $50,000 of common shares to Vectus.

![](logo.jpg)<sub>7</sub>

On January 13, 2026, the Company entered into an amendment that provides for closing of the Vectus transaction on or before March 31, 2026 to provide additional time for transfer of intellectual property.

**Regulatory Advancements**

On January 3, 2024, the Company announced the submission of a new patent for the treatment of chronic kidney disease (**"CKD"**). This patent is designed to protect new discoveries and strategies for the treatment of individuals with varied degrees of kidney function in the setting of CKD.

On April 28, 2025, the Company announced receipt of notification that the patent "Xanthine Oxidase Inhibitor Formulations" will be granted by the European Patent Office. The patent covers compositions and methods of formulating using XORTX's proprietary formulations of XOI for the treatment of health consequences of chronically high uric acid, gout, renal, cardiovascular and other diseases where aberrant purine metabolism has been implicated in disease progression.

On April 30, 2025, the Company announced that it had received responses from the FDA on its Type B Meeting Package related to the development of XRX-026 for the treatment of gout. The responses clarified the remaining steps for submission of an NDA to gain approval through the Section 505(b)(2) regulatory pathway. Final FDA minutes are pending formalization by XORTX and the FDA.

**Changes in Officers and Directors**

On December 31, 2025, the Company announced the appointment of Ms. Krysta Davies Foss to the Board of Directors and the resignations of Messrs. Bill Farley, Patrick Treanor and Ms. Abigal Jenkins.

#### Nasdaq Compliance
On April 17, 2025, the Company announced that it received notification from Nasdaq Listing Qualifications Department that it was not in compliance with the minimum bid price requirement set forth in Nasdaq Rule 5550(a)(2) since the closing bid price for the Company's common shares listed on Nasdaq was below US$1.00 for 30 consecutive business days. Nasdaq Rule 5550(a)(2) requires the shares to maintain a minimum bid price of US$1.00 per share, and Nasdaq Rule 5810(c)(3)(A) provides that failure to meet such a requirement exists when the bid price of the shares is below US$1.00 for a period of 30 consecutive business days. In accordance with Listing Rule 5810(c)(3)(A), the Company has a period of 180 days from the date of notification to regain compliance with the minimum bid price requirement, during which time the shares will continue to trade on the Nasdaq Capital Market. If at any time before the 180 day period, the bid price of the shares closes at or above US$1.00 per share for a minimum of 10 consecutive business days, Nasdaq has the discretion to provide written notification that the Company has achieved compliance with the minimum bid price requirement and consider such deficiency matters closed. As at the date of this MD&A, the Company has not met the minimum bid price requirement. The Company made an application to Nasdaq to extend the compliance period for a further 180 days to regain compliance. On October 20, 2025, the Company received a notice from Nasdaq granting the Company's request for a 180-day extension to regain compliance with the minimum bid price requirement. The Company now has until April 13, 2026 to meet the requirement (the "Second Compliance Period").

If at any time during the Second Compliance Period, the closing bid price of the Company's common shares is at least $1 per share for at least a minimum of 10 consecutive business days, Nasdaq will provide the Company with written notification that the Company has achieved compliance with the Minimum Bid Requirement and will consider deficiency matters closed. If compliance with the Minimum Bid Price Requirement cannot be demonstrated by April 13, 2026, Nasdaq will provide written notification that the Company's common shares will be delisted. At that time, the Company may appeal Nasdaq's determination to a Nasdaq Hearings Panel (the "Panel"). The Company would remain listed pending the Panel's decision. There can be no assurance that if the Company does appeal a subsequent delisting determination, that such appeal would be successful. Accordingly, there can be no assurance that the Company will be able to regain compliance with the Minimum Bid Price Requirement or maintain its listing on The Nasdaq Capital Market.

![](logo.jpg)<sub>8</sub>

#### FUTURE PLANS AND OUTLOOK
XORTX intends to grow its business by developing four programs: one for the treatment of gout (XRx-026); one for the treatment of ADPKD (XRx-008); one to treat AKI associated with respiratory virus infection and associated health consequences (XRx-101); and a final program for the treatment of T2DN (XRx-225).

Recent independent peer-reviewed research that reported that genetic factors are linked to the over-expression of xanthine oxidase ("**XO**") and play a role in several diseases, including kidney disease, have provided the Company with the opportunity to develop diagnostics that identify specific genetic factors. These diagnostic tools alongside the Company's expertise in developing unique formulations of uric acid lowering agents and XO inhibitors will permit XORTX to tailor treatments to subpopulations of individuals that have common susceptibility or similar responses to particular drugs. The Company will begin evaluating individuals as early as our planned registration clinical trial in patients with ADPKD providing XORTX with an opportunity to better understand the role these genetic factors play in progressive kidney disease.

In 2026, XORTX will focus on advancing its proprietary formulation of oxypurinol – XORLO<sup>TM</sup> – in the XRx-026 program to provide a therapeutic option to patients with allopurinol intolerant gout. It will submit an IND, conduct a pharmacokinetics clinical trial, manufacture a clinical and commercial supply of drug, and in parallel, prepare a US FDA marketing approval application. The Company will also continue to advance a unique proprietary formulation of oxypurinol for the XRx-008 program for ADPKD and for efficacy testing during a Phase 2/3 "registration" clinical trial program – XRX-OXY-201. Discussions with the FDA and initiation of commercialization activities for XORLO<sup>TM</sup> will be a priority as will advancing research in other kidney disease applications. To achieve these objectives, XORTX's action plan includes:

1. **To advance the XRx-026 program for the treatment of gout, with a specific focus on allopurinol intolerant gout.** Recently, the Company submitted a Type B Meeting Package with the FDA. The FDA responses clarified the remaining steps for submission
of a NDA to gain approval through the Section 505(b)(2) regulatory pathway. Final FDA minutes are pending formalization by XORTX and the
FDA. The Type B Meeting Package included the clinical development history including phase 1, 2 clinical study results, a prior approvable
letter from the FDA for oxypurinol for gout. Pending further communications from the FDA, the Company anticipates submitting an IND, conducting
a pharmacokinetics clinical trial, initiating clinical and commercial supply manufacturing of drug product, preparing a NDA for submission
in fiscal 2026, entering discussions with potential marketing and selling partners in the US and in other major global markets, and preparing
for commercialization in 2027. (Estimated cost - $9 to $18 million.)

2. **Under the XRx-008 program, to initiate the Pivotal Registration clinical trial "XRX-OXY-201", to support an application for the "Accelerated Approval" of a proprietary formulation of oxypurinol for individuals with ADPKD.** The XRX-OXY-201 clinical trial is a Phase 2b/3a, Multi-Centre, Double-Blind, Placebo Controlled, Randomized Withdrawal Design Study
to Evaluate the Efficacy and Safety of a Novel Oxypurinol Formulation in Patients with Progressing Stage 3-4 ADPKD and Coexistent Hyperuricemia.
The XRX-OXY-201 clinical trial will provide data for future "accelerated approval" NDA submissions to the FDA, and MAA submissions
to the EMA. Subject to available financing, the XRX-OXY-201 clinical trial is planned to start in 2026 and enroll individuals with stage
3 or 4 ADPKD and presenting with chronically high serum uric acid levels. The objective of the XRX-OXY-201 clinical trial is to evaluate
the ability of oxypurinol to slow the rate of decline of the glomerular filtration rate in ADPKD patients and/or the expansion of total
kidney volume over a 12-month treatment period. An estimated 150 patients will be enrolled with 120 patients completing the study. (Estimated
cost - $5 million to $30 million.)

3. **Under the XRx-008 program, prepare and communicate with the FDA and EMA regarding a second phase clinical trial named "XRX-OXY-301", a full registration trial in ADPKD patients.** The XRX-OXY-301 clinical trial is a Phase 3, Multi-Centre,
Double-Blind, Placebo Controlled, Randomized Withdrawal Design Study to Evaluate the Efficacy and Safety of a Novel Oxypurinol Formulation
in Patients with Progressing Stage 2-4 ADPKD and Coexistent Hyperuricemia with Progressing Stage 2, 3, or 4 Kidney Disease. The objective
of the XRX-OXY-301 clinical trial is to evaluate the safety and effectiveness of oxypurinol for the XRx-008 program over a 24-month treatment
period and obtain FDA marketing approval and to characterize its ability to decrease the rate of decline of glomerular filtration rate.
An estimated 300 patients will be enrolled. The XRX-OXY-301 clinical trial will not be scheduled or budgeted until XRX-OXY-201 is well
underway and may be subject to SPA review by FDA.

![](logo.jpg)<sub>9</sub>

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4. **Ongoing CMC Work.** In parallel with the preparation of regulatory communications with the FDA, the
production of clinical and commercial supplies of XORLO<sup>TM</sup> for the XRx-026 program and pharmacokinetics clinical study –
XRX-OXY-102 will be initiated. XORTX will focus on scale-up, validation and stability testing of clinical drug product supplies of XORLO<sup>TM</sup>
under a new IND for gout, as well as building, validating and characterizing the stability of future clinical and commercial supplies.
All development will be performed according to current GMP methodology. This work will be ongoing throughout 2026 to 2027. (Estimated
cost of Clinical and Commercial drug supply - $5 million to $10 million.)

5. **Activities Related to Potential Commercial Launch.** In preparation for a possible commercial launch
of the XORLO<sup>TM</sup> product associated with the XRx-026 development program, XORTX will conduct commercialization studies and an
in-depth analysis of pricing and reimbursement, as well as evaluate product brand name selection, prepare related filings and conduct
other launch preparation activities. In addition, similar work will be conducted for the XRx-008 program. This work will be ongoing throughout
2026 to 2027. (Estimated cost - $2 to $8 million.)

6. **Activities Related to European Registration.** XORTX will continue to work with and obtain guidance
from the EMA to facilitate the path to potential approval of its XRx-026 and XRx-008 programs in the EU. This work will be ongoing in
2026 through 2027 and will include updating its information dossier to support an orphan drug designation from the EMA. (Estimated cost
- $1 to $8 million.)

To achieve the above goals, XORTX will continue to pursue non-dilutive and dilutive funding and expand discussions to partner with major pharma / biotech companies with a global reach. XORTX will also increase financial and healthcare conference participation to further strengthen and expand its investor base.

#### SUMMARY OF QUARTERLY RESULTS
The following table sets forth unaudited quarterly results prepared by management for the eight previous quarters to December 31, 2025:

---

| | | | | |
|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;&nbsp;(unaudited) | **2025 Q4** | **2025 Q3** | **2025 Q2** | **2025 Q1** |
| &nbsp;&nbsp;Research and development | 54864 | 57011 | 186751 | 276309 |
| &nbsp;&nbsp;Consulting, wages and benefits | 237301 | 238839 | 240532 | 283915 |
| &nbsp;&nbsp;Directors' fees | 57359 | 56956 | 57973 | 43280 |
| &nbsp;&nbsp;Investor relations | 75683 | 214253 | 155859 | 150043 |
| &nbsp;&nbsp;Professional fees | 135710 | 30902 | 100882 | 81834 |
| &nbsp;&nbsp;General and administrative | 60615 | 61125 | 59495 | 59797 |
| &nbsp;&nbsp;Public company costs | 31645 | 22592 | 43734 | 22364 |
| &nbsp;&nbsp;Travel |  | 17 | 10144 | 10960 |
| &nbsp;&nbsp;Amortization of property and equipment | 22537 | 22888 | 20841 | 19464 |
| &nbsp;&nbsp;Amortization of intangible assets | 6578 | 6497 | 6789 | 6521 |
| &nbsp;&nbsp;Impairment of intangible assets | 1833 |  |  |  |
| &nbsp;&nbsp;Share based payments <sup>(</sup>1) | 4124 | 5117 | 6945 | 8969 |
| &nbsp;&nbsp;Gain on derivative warrant liability | (93000) | (76000) | (149000) | (246000) |
| &nbsp;&nbsp;Foreign exchange (gain) loss | (865) | 16473 | (10919) | (362) |
| &nbsp;&nbsp;Interest income | (3922) | (7201) | (12326) | (18421) |
| &nbsp;&nbsp;Total (loss) income | (590462) | (649469) | (717700) | (698673) |
| &nbsp;&nbsp;(Loss) income per share | (0.09) | (0.13) | (0.19) | (0.19) |

---

![](logo.jpg)<sub>10</sub>

---

| | | | | |
|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;&nbsp;(unaudited) | **2024 Q4** | **2024 Q3** | **2024 Q2** | **2024 Q1** |
| &nbsp;&nbsp;Research and development | 7763 | 34741 | 67683 | 73643 |
| &nbsp;&nbsp;Consulting, wages and benefits | 256569 | 213340 | 360617 | 224721 |
| &nbsp;&nbsp;Directors' fees | 42467 | 40144 | 46371 | 39161 |
| &nbsp;&nbsp;Investor relations | 181897 | 236603 | 502265 | 439405 |
| &nbsp;&nbsp;Professional fees | 26487 | 195527 | 274635 | 120210 |
| &nbsp;&nbsp;General and administrative | 72006 | 81765 | 92258 | 74920 |
| &nbsp;&nbsp;Public company costs | 24845 | 30823 | 56053 | 29683 |
| &nbsp;&nbsp;Travel | 13581 |  | 16728 | 1607 |
| &nbsp;&nbsp;Amortization of property and equipment | 19513 | 19560 | 26885 | 20246 |
| &nbsp;&nbsp;Amortization of intangible assets | 6631 | 6389 | 6164 | 11886 |
| &nbsp;&nbsp;Share based payments <sup>(</sup>1) | 9505 | 15857 | 44031 | 53134 |
| &nbsp;&nbsp;Loss/(gain) on derivative warrant liability | (870349) | (244000) | (1645548) | 1724792 |
| &nbsp;&nbsp;Foreign exchange loss (gain) | 57336 | (14715) | 17744 | 12644 |
| &nbsp;&nbsp;Interest income | (25331) | (29023) | (35952) | (31602) |
| &nbsp;&nbsp;Transaction costs on derivative warrant liability | 54545 | - | - | 224486 |
| &nbsp;&nbsp;Total (loss) income | 122535 | (587011) | 170066 | (3018936) |
| &nbsp;&nbsp;(Loss) income per share | 0.04 | (0.20) | 0.06 | (1.24) |

---

Note: <sup>(1)</sup> Share based payments relate to the vesting of options over the period.

**Three months ended December 31, 2025**

The Company had a net loss of $590,462 ($0.09 per share) for the three months ended December 31, 2025, compared to a net income of $122,535 ($0.04 per share) in the three months ended December 31, 2024.

Variances within the loss items are as follows:

***Consulting, wages and benefits*** - $237,301 (2024 - $256,569) – Consulting expenses decreased during the three months ended December 31, 2025, as fewer consultants were engaged during the current quarter due to a decrease in Company activity with respect to corporate development.

 ****

***Investor relations*** - $75,683 (2024 - $181,897) – Investor relations expense decreased during the three months ended December 31, 2025 as the Company decreased its marketing and promotional activities.

***Professional fees*** - $135,710 (2024 - $26,487). Professional fees, which consists mainly of accounting, audit and legal fees, increased during the three months ended December 31, 2025 as compared with the 2024 period, due to the Company's increased corporate activity.

 ****

***Research and development*** - $54,864 (2024 - $7,763) – Research and development expenses increased in the three months ended December 31, 2025 compared to the same period last year as detailed in the following table:

The table below presents combined research and development costs for XRx-026, XRx-008, XRx-101, and XRx-225 as many of the Company's program activities are run concurrently and in combination.

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Q4 2025** | **Q4 2024** | **Change $** | **Change %** |
| Clinical trial expenses <sup>1</sup> | 17992 | (32400) | 50393 | 156% |
| Manufacturing and related process expenses <sup>2</sup> | 9880 | 12948 | (3068) | (24%) |
| Intellectual property expenses <sup>3</sup> | 840 | 1540 | (700) | (45%) |
| External consultants' expenses <sup>4</sup> | 26152 | 25675 | 476 | 2% |
| Total Research and development | 54864 | 7763 | 47101 | 607% |

---

Notes:

(1) Clinical
 trials expenses include those costs associated with our XRx-026, XRx-008 and XRx-101 programs.
 Included in clinical trials expenses are regulatory and consulting activities, contract research
 organization expenses, data management expenses, and other costs associated with our clinical
 trial programs. Clinical trial expenses increased mainly as the Company's updating
 its information dossier to support an orphan drug designation from the EMA and the submission
 of the Type B Meeting Package to the FDA. In Q4 2024, a recovery of $32,452 was due to the
 write-off of pre-existing accounts payable.

![](logo.jpg)<sub>11</sub>

(2) Manufacturing
 and related process expenses includes third party direct manufacturing costs, quality control
 testing and packaging costs. In Q4 2025, manufacturing costs primarily related to the Company's
 oxypurinol quality control and stability related costs.

(3) Intellectual
 property expenses include legal and filing and maintenance fees associated with our patent
 portfolio.

(4) External
 consultants' expenses include third party consultants engaged in the activities of
 research and development including chemistry, manufacturing, drug product development, regulatory,
 non-clinical and clinical study execution. The external consultants' expenses are largely
 comparable for the three months ended December 31, 2025 to the same period in 2024.

***Foreign Exchange gain*** - $865 (2024 – loss of $57,336) – Foreign exchange gain increased to $865 for the three months ended December 31, 2025 due to the USD/CAD foreign exchange rate strengthening. Foreign exchange gains or losses result from balances which are held in currencies other than the functional currency of the Company.

 ****

***Gain on derivative warrant liability*** - $93,000 (2024 – $870,319) – During the three months ended December 31, 2025, the gain relates to a decrease in the Company's share price and a decrease in the remaining terms of the warrants which decreases the value of the derivative warrant liability. The warrants included in the units issued under the offering in Q1 2024 have an exercise price in CAD dollars and are considered a derivative financial liability as the exercise price is in a different currency than the functional currency of the entity. The warrants are initially recognized at fair value and subsequently remeasured at fair value with changes recognized through profit or loss.

**Year ended December 31, 2025**

The Company incurred a loss of $2,656,304 ($0.56 per share) for the year ended December 31, 2025, compared to a loss of $3,313,346 ($1.15 per share) in the year ended December 31, 2024.

Variances within the loss items are as follows:

***Consulting, wages and benefits*** - $1,000,587 (2024 - $1,055,247) – Consulting expenses decreased during the year ended December 31, 2025, as fewer consultants were engaged during the current quarter due to a decrease in Company activity with respect to corporate development.

***Directors' fees*** - $215,568 (2024 - $168,143) – Directors' fees expenses increased during the year ended

December 31, 2024, due to an increase in director fees related to the non-executive Chairman and increased director and committee meetings.

***General and administrative*** - $241,032 (2024 - $320,949) – General and administrative expenses decreased due to lower directors' and officers' insurance premiums.

***Investor relations*** - $595,838 (2024 - $1,360,170) – Investor relations expenses decreased during the year ended December 31, 2025 as the Company decreased its marketing and promotional activities.

***Professional fees*** - $349,328 (2024 - $616,859). Professional fees, which consists mainly of accounting, audit and legal fees, decreased during the year ended December 31, 2025 as compared with the 2024 period, due to the Company's decreased corporate activity.

***Research and development*** - $574,935 (2024 - $183,830) – Research and development expenses increased in the year ended December 31, 2025, compared to the same period last year as detailed in the following table (future expenditures will depend upon financial resources available):

The table below presents combined research and development costs for XRx-026, XRx-008, XRx-101, and XRx-225 as many of the Company's program activities are run concurrently and in combination.

![](logo.jpg)<sub>12</sub>

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **2025** | **2024** | **Change $** | **Change %** |
| Clinical trial expenses <sup>1</sup> | 188107 | (19282) | 207389 | 1076% |
| Manufacturing and related process expenses <sup>2</sup> | 27359 | 62722 | (35363) | (56%) |
| Intellectual property expenses <sup>3</sup> | 13785 | 12406 | 1379 | 11% |
| Translational science expenses <sup>4</sup> | 237464 |  | 237464 | 100% |
| External consultants' expenses <sup>5</sup> | 108220 | 127984 | (19764) | (15%) |
| Total Research and development | 574935 | 183830 | 391105 | 213% |

---

Notes:

(1) Clinical
 trials expenses include those costs associated with our XRx-026, XRx-008 and XRx-101 programs.
 Included in clinical trials expenses are regulatory and consulting activities, contract research
 organization expenses, data management expenses, and other costs associated with our clinical
 trial programs. Clinical trial expenses increased mainly as the Company's updating
 its information dossier to support an orphan drug designation from the EMA and the submission
 of the Type B Meeting Package to the FDA. Clinical trials expense decreased mainly in 2024
 as the bridging pharmacokinetics study was mostly completed at the end of 2022 as compared
 to the comparative period when the XRX-OXY-101 PK Clinical Trial was starting as a new expense.
 In Q4 2024, a recovery of $32,452 was due to the write-off of pre-existing accounts payable.

(2) Manufacturing
 and related process expenses includes third party direct manufacturing costs, quality control
 testing and packaging costs. In Q4 2025, manufacturing costs primarily related to the Company's
 oxypurinol quality control and stability related costs.

(3) Intellectual
 property expenses include legal and filing and maintenance fees associated with our patent
 portfolio.

(4) Translational
 science expenses include various research studies conducted to expand our intellectual knowledge
 base related to oxypurinol and our proprietary formulations of oxypurinol, pharmacokinetic
 testing, non-clinical bioavailability studies, pharmacology and toxicology testing, and identifying
 potential licensing opportunities.

(5) External
 consultants' expenses include third party consultants engaged in the activities of
 research and development including chemistry, manufacturing, drug product development, regulatory,
 non-clinical and clinical study execution. The external consultants' expenses are largely
 comparable for the year ended December 31, 2025 to the same period in 2024.

***Foreign Exchange loss*** - $4,327 (2024 – $73,009) – Foreign exchange loss decreased to $4,327 for the year ended December 31, 2025 due to the USD/CAD foreign exchange rate strengthening. Foreign exchange gains or losses result from balances which are held in currencies other than the functional currency of the Company.

 ****

***Gain on derivative warrant liability*** - $564,000 (2024 – $1,035,105) – During the year ended December 31, 2025, the gain relates to a decrease in the Company's share price and a decrease in the remaining terms of the warrants which decrease the value of the derivative warrant liability. The warrants included in the units issued under the offering in Q1 2024 have an exercise price in CAD dollars and are considered a derivative financial liability as the exercise price is in a different currency than the functional currency of the entity. The warrants are initially recognized at fair value and subsequently remeasured at fair value with changes recognized through profit or loss.

**Selected Annual Financial Information** 

The financial information reported herein has been prepared in accordance with IFRS. The Company uses the U.S. dollar as its presentation currency. The following table represents selected financial information for the Company's fiscal years 2025, 2024 and 2023.

**Selected Statements of Comprehensive Loss Data**

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| | | | |
|:---|:---|:---|:---|
| | **2025** | **2024** | **2023** |
| Revenue | $Nil | $Nil | $Nil |
| Loss and comprehensive loss for the year | $2656304 | $3313346 | $2158065 |
| Weighted average shares outstanding | 4734633 | 2878514 | 1981734 |
| Loss per share, basic and diluted | $0.56 | $1.15 | $1.09 |

---

![](logo.jpg)<sub>13</sub>

**Selected Statements of Financial Position Data**

---

| | | | |
|:---|:---|:---|:---|
| | **Dec. 31, 2025** | **Dec. 31, 2024** | **Dec. 31, 2023** |
| Cash and cash equivalents | 864514 | $2473649 | $3447665 |
| Net working capital | 662027 | $1918708 | $3242845 |
| Total assets | 2683530 | $4094527 | $5467964 |
| Long-term liabilities | $Nil | $Nil | $Nil |

---

**Comparison of Operations for the 2025 and 2024 Financial Years**

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **2025** | **2024** | **Change $** | **Change %** |
| Research and development | 574935 | 183830 | 391105 | 213% |
| Consulting, wages and benefits | 1000587 | 1055247 | (54660) | (5%) |
| Directors' fees | 215568 | 168143 | 47425 | 28% |
| Investor relations | 595838 | 1360170 | (764332) | (56%) |
| Professional fees | 349328 | 616859 | (267531) | (43%) |
| General and administrative | 241032 | 320949 | (79917) | (25%) |
| Public company costs | 120335 | 141404 | (21069) | (15%) |
| Travel | 21121 | 31916 | (10795) | (34%) |
| Amortization | 112115 | 117274 | (5159) | (4%) |
| Impairment of tangibles | 1833 | - | 1833 | 100% |
| Share-based payments | 25155 | 122527 | (97372) | (79%) |
| Gain on derivative warrant liability | (564000) | (1035105) | 471105 | (46%) |
| Foreign exchange loss | 4327 | 73009 | (68682) | (94%) |
| Interest income and other expenses | (41870) | (121908) | 80038 | (66%) |
| Transaction costs on derivative warrant liability | - | 279031 | (279031) | (100%) |
| Loss for the Year | 2656304 | 3313346 | (657042) | (20%) |
| Loss per Share | 0.56 | 1.15 | (0.59) | 51% |

---

#### Comparison of cash flows for the years ended December 31, 2025 and 2024
The Company realized a net cash outflow of $1,609,135 for the year ended December 31, 2025, compared to a cash outflow of $974,016 for the year ended December 31, 2024. The variances in the cash flow for the year ended December 31, 2025, compared to December 31, 2024 were as follows:

***Operating activities*** – Cash used in operating activities for the year ended December 31, 2025, was $2,768,723(2024 - $3,678,648). The cash used in operating activities was related to the net loss during the year and non-cash items.

***Investing activities*** – Cash used in investing activities for the year ended December 31, 2025, was $294,953 (2024 - $38,924). The cash used was related to the acquisition of intangible assets during the periods.

 ****

***Financing activities*** – Cash provided by financing activities in the year ended December 31, 2025, was $1,427,544 (2024 –$2,779,509). The cash provided was primarily related to the at-the-market offering that took place in January, the non-brokered private placements that took place in July and August, and the registered direct offering that took place in October, for aggregate gross proceeds of $2,255,535. The cash used was related to share issuance costs of $738,433, deferred acquisition costs of $293,803, and payment of lease obligation of $89,572.

![](logo.jpg)<sub>14</sub>

#### LIQUIDITY AND CAPITAL RESOURCES
As at December 31, 2025, the Company had a cash balance of $864,514 and working capital of $662,027 as compared to a cash balance of $2,473,649 and working capital of $1,918,708 as at December 31, 2024. Working capital included a non-cash component related to derivative warrant liability of $8,000 (2024 - $572,000). If this non-cash amount was excluded, working capital would have been $670,027 (2024 - $2,490,708). During the year ended December 31, 2025, the Company closed an at-the-market offering that consisted of 73,871 common shares at an average price of CAD $1.5371 per share for aggregate gross proceeds of CAD $113,547, a non-brokered private placement of 1,267,123 units at a price of $0.73 per unit for aggregate gross proceeds of $925,000, a non-brokered private placement of 156,849 units at a price of $0.73 per unit for aggregate gross proceeds of $114,500, and closed a registered direct offering for the purchase and sale of 572,470 common share units at $0.63 per unit and 1,177,530 pre-funded warrant units at $0.62999 per unit for aggregate gross proceeds of $1,102,488.

Although there is no certainty, management is of the opinion that additional funding for its projects and operations can be raised as needed. The Company is subject to a number of risks associated with the successful development of new products and their marketing and the conduct of its clinical studies and their results. The Company will have to finance its research and development activities and its clinical studies. To achieve the objectives in its business plan, the Company plans to raise the necessary capital and to generate revenue. The products developed by the Company will require approval from the FDA and equivalent organizations in other countries before their sale can be authorized. If the Company is unsuccessful in obtaining adequate financing in the future, corporate initiatives will be affected. The Company's current cash burn is approximately $215,000 per month, however dependent on financing activities, the timing of expenditures will be adjusted.

#### USE OF FINANCING PROCEEDS
The Company will use its existing and any future cash resources to fund its operations and general corporate purposes, including further research and development, and the manufacturing of active pharmaceutical ingredients and drug product to support clinical trials and regulatory approval.

**COMMITMENTS**

The Company has long-term commitments that are not recognized as liabilities as at December 31, 2025 and 2024 as follows:

**Employment Agreements**

---

| | | |
|:---|:---|:---|
| | **December 31, <br>2025** | **December 31, <br>2024** |
|  | **$** | **$** |
| &nbsp;&nbsp;Management services – officers | 321000 | 321000 |

---

The President, CEO and a director of the Company has a long-term employment agreement with the Company. The agreement has a termination clause whereby he is entitled to the equivalent of 12 times his current monthly salary which, as of December 31, 2025 and 2024, equated to an annual salary of $321,000.

**Payments** 

In the normal course of business, the Company has committed to payments totaling $107,028 (December 31, 2024 - $323,000) for activities related to its clinical trials, manufacturing, collaboration programs and other regular business activities which are expected to occur over the next two years.

#### OFF BALANCE SHEET ARRANGEMENTS
The Company has no off-balance sheet arrangements.

---

| | |
|:---|:---|
| ![](logo.jpg) | 15 |

---

#### TRANSACTIONS WITH RELATED PARTIES
All related party transactions were measured at fair value. All amounts due from/payable to related parties are unsecured, non-interest bearing and have no fixed terms of repayment.

During the year ended December 31, 2025, the Company incurred the following transactions with related parties:

&nbsp;&nbsp;&nbsp;&nbsp;a) Wages and benefits and professional fees were paid or accrued to Allen Davidoff, the Chief Executive Officer
("CEO"), in the amount of $324,738 (2024 - $391,655; 2023 - $337,794).

&nbsp;&nbsp;&nbsp;&nbsp;b) Fees were paid or accrued to Michael Bumby, the Chief Financial Officer ("CFO") of the Company
in the amount of $160,980 (2024 - $156,335 (paid or accrued to the former and current CFO; 2023 - $156,217 (paid or accrued to the former
CFO)).

&nbsp;&nbsp;&nbsp;&nbsp;c) Research and development fees were paid or accrued to Haworth Biopharmaceutical Consulting Services Inc.,
a company owned by Stephen Haworth, the Chief Medical Officer ("CMO") of the Company in the amount of $96,000 (2024 - $110,445;
2023 - $200,229).

&nbsp;&nbsp;&nbsp;&nbsp;d) Consulting fees were paid or accrued to Stacy Evans, the Chief Business Officer ("CBO") of
the Company in the amount of $150,000 (2024 - $157,500; 2023 - $280,000).

&nbsp;&nbsp;&nbsp;&nbsp;e) Directors' fees were paid or accrued to the directors of the Company in the amount of $215,568 (2024
- $172,229; 2023 - $182,675). The amount includes director fees payment of $128,877 for the year ended December 31, 2025 (2024 - $123,133;
2023 - $133,967) to Anthony Giovinazzo, Chairman of the Company.

&nbsp;&nbsp;&nbsp;&nbsp;f) As at December 31, 2025, $10,730 (2024 - $11,120) was payable to directors of the Company, $28,044 (2024
- $7,705) was payable and accrued to the CFO of the Company for CFO services, $16,000 (2024 - $8,000) was payable and accrued to the CMO
of the Company for consulting services, and $37,500 (2024 - $12,500) was payable and accrued to the CBO of the Company for consulting
services. The balances are unsecured, non-interest bearing, and have no fixed terms of repayment.

&nbsp;&nbsp;&nbsp;&nbsp;g) Management and directors' key management compensation transactions for the years ended December
31, 2025, 2024, and 2023 are summarized as follows:

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Management<br> Compensation** | **Directors'<br>fees** | **Share-<br> based <br> payments** | **Total** |
|  | **$** | **$** | **$** | **$** |
| Year ended December 31, 2023 |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Directors and officers | 974240 | 182675 | 77779 | 1234694 |
| Year ended December 31, 2024 |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Directors and officers | 815935 | 172229 | 85680 | 1073845 |
| Year ended December 31, 2025 |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Directors and officers | **731718** | **215568** | **14559** | **961845** |

---

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|:---|:---|
| ![](logo.jpg) | 16 |

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**FINANCIAL AND CAPITAL RISK MANAGEMENT**

The Company's financial instruments consist of cash, accounts receivable, accounts payable and accrued liabilities, lease obligation and derivative warrant liability. The fair values of cash and accounts payable and accrued liabilities approximate their carrying values at December 31, 2025, due to their short-term nature.

The following table presents the Company's financial instruments, measured at fair value on the consolidated statements of financial position as at December 31, 2025 and 2024 and categorized into levels of the fair value hierarchy:

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| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | | **December 31, 2025** | **December 31, 2024** | **December 31, 2024** | **December 31, 2024** |
| | Level | **Carrying <br> Value** | | **Carrying <br> Value** | **Estimated <br> Fair Value** |
|  |  | **$** | $— | **$** | **$** |
| **FVTPL** |  |  |  |  |  |
| Derivative warrant liability | 3 | 8000 |  | 572000 | 572000 |

---

There were no transfers for levels of change in the fair value measurements of financial instruments for the years ended December 31, 2025 and 2024 and 2023.

Risk management is carried out by the Company's management team with guidance from the Board of Directors. The Company's risk exposures and their impact on the Company's financial instruments were as follows:

&nbsp;&nbsp;&nbsp;&nbsp;**a)** **Credit risk** 

Credit risk is the risk of financial loss to the Company if a customer of counterparty to a financial instrument fails to meet its obligations. The Company's maximum exposure to credit risk at the financial position date under its financial instruments is summarized as follows:

---

| | | |
|:---|:---|:---|
| | **December 31, <br> 2025** | **December 31, <br> 2024** |
|  | **$** | **$** |
| **Cash** | 864514 | 2473649 |

---

All of the Company's cash is held with major financial institutions in Canada and management believes the exposure to credit risk with such institutions is minimal. The Company considers the risk of material loss to be significantly mitigated due to the financial strength of the major financial institutions where cash is held. The Company has no exposure to the ongoing banking crisis. The Company's maximum exposure to credit risk as at December 31, 2025 and 2024 is the carrying value of its financial assets.

&nbsp;&nbsp;&nbsp;&nbsp;**b)** **Liquidity risk** 

Liquidity risk is the risk that the Company will not be able to meet its obligations associated with financial liabilities. The Company has a planning and budgeting process in place by which it anticipates and determines the funds required to support normal operation requirements as well as the growth and development of its intellectual property portfolio.

The Company's financial assets are comprised of its cash, accounts receivable and the financial liabilities are comprised of its accounts payable and accrued liabilities, and lease liability.

The contractual maturities of these financial liabilities as at December 31, 2025 and 2024 are summarized in the following table:

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|:---|:---|
| ![](logo.jpg) | 17 |

---

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Payments due by period as of December 31, 2025** | **Payments due by period as of December 31, 2025** | **Payments due by period as of December 31, 2025** | **Payments due by period as of December 31, 2025** |
| | **Total** | **Less than <br> 3 months** | **Between 3<br> months <br> and 1 year** | **1-3 years** |
|  | **$** | **$** | **$** | **$** |
| Accounts payable and accrued liabilities | 553784 | 553784 |  |  |
| Lease liability | 37287 | 22230 | 15057 | - |
|  | 591071 | 576014 | 15057 | - |

---

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Payments due by period as of December 31, 2024** | **Payments due by period as of December 31, 2024** | **Payments due by period as of December 31, 2024** | **Payments due by period as of December 31, 2024** |
| | **Total** | **Less than <br> 3 months** | **Between 3<br> months <br> and 1 year** | **1-3 years** |
|  | **$** | **$** | **$** | **$** |
| Accounts payable and accrued liabilities | 147205 | 147205 |  |  |
| Lease liability | 38785 | 23124 | 15661 | - |
|  | 185990 | 170329 | 15661 | - |

---

&nbsp;&nbsp;&nbsp;&nbsp;**c)** **Market risk** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;i) Interest Rate Risk

Interest rate risk is the risk that the fair value of future cash flows of a financial instrument will fluctuate due to changes in market interest rates. The Company's bank accounts bear interest. Management believes that the credit risk concentration with respect to financial instruments included in cash is minimal.

ii) Foreign Currency Risk

As at December 31, 2025, the Company is exposed to currency risk on the following financial assets and liabilities denominated in Canadian Dollars ("CAD"). The sensitivity of the Company's net earnings due to changes in the exchange rate between the CAD against the U.S. dollar is included in the table below in U.S. dollar equivalents:

---

| |
|:---|
| Cash |
| Accounts payable and accrued liabilities |
| **Net exposure** |
| **Effect of +/- 10% change in currency** |

---

The Company thoroughly examines the various financial instruments and risks to which it is exposed and assesses the impact and likelihood of those risks. These risks include foreign currency risk, interest rate risk, market risk, credit risk, and liquidity risk. Where material, these risks are reviewed and monitored by the Board of Directors.

There have been no changes in any risk management policies since December 31, 2024.

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|:---|:---|
| ![](logo.jpg) | 18 |

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#### Capital Management
The Company defines the capital that it manages as shareholders' equity. The Company manages its capital structure in order to have funds available to support its research and development and sustain the future development of the business. When managing capital, the Company's objective is to ensure the entity continues as a going concern as well as to achieve optimal returns for its shareholders and to provide benefits for its other stakeholders. Management adjusts the capital structure as necessary in order to support its activities.

The Company includes the following items in its managed capital as at the following periods:

---

| |
|:---|
| **Equity is comprised of:** |
| Share capital |
| Reserves |
| Obligation to issue shares |
| Accumulated other comprehensive loss |
| Deficit |

---

Since inception, the Company's objective in managing capital is to ensure sufficient liquidity to finance its research and development activities, general and administrative expenses, expenses associated with intellectual property protection and its overall capital expenditures. There were no changes during the year ended December 31, 2025. The Company is not exposed to external requirements by regulatory agencies regarding its capital.

#### OUTSTANDING SHARE DATA
The Company has an unlimited number of unauthorized common shares without par value.

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| | |
|:---|:---|
| **Type of Security** | **Common shares** |
| As of February 25, 2026 | (number) |
| Issued and outstanding | 6962218 |
| Stock options | 149761 |
| Share purchase warrants | 3309880 |
| Fully diluted shares outstanding | 10421859 |

---

#### RISKS RELATED TO THE BUSINESS
An investment in the Company is speculative and involves a high degree of risk. Accordingly, prospective investors should carefully consider the specific risk factors set out below, in addition to the other information contained in this MD&A, before making any decision to invest in the Company. The directors and officers of the Company consider the following risks and other factors to be the most significant for potential investors in the Company, but the risks listed do not necessarily comprise all those associated with an investment in the Company and are not set out in any particular order of priority. Additional risks and uncertainties not currently known to the Company's directors and officers may also have an adverse effect on the Company's business. If any of the following risks actually occur, the Company's business, financial condition, capital resources, results or future operations could be materially adversely affected. In such a case, the price of the common shares could decline, and investors may lose all or part of their investments.

For additional discussion on XORTX's risks, refer to the "Risk Factors" section of the Company's Annual Information Form and the Form 20-F for the year ended December 31, 2025, as well as to the "Forward Looking Statements" section of this MD&A.

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|:---|:---|
| ![](logo.jpg) | 19 |

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#### Speculative Nature of Investment Risk
An investment in the common shares of the Company carries a high degree of risk and should be considered as a speculative investment by purchasers. The Company has limited cash reserves, a limited operating history, has not paid dividends, and is unlikely to pay dividends in the near future. The Company's programs are in the development stage. Operations are not yet sufficiently established such that the Company can mitigate the risks associated with its planned activities.

**Limited Operating History**

The Company does not currently generate revenue from the sale of products. The Company is therefore subject to many of the risks common to early-stage enterprises, including under-capitalization, cash shortages, limitations with respect to personnel, financial, and other resources. There is no assurance that the Company will be successful in achieving a return on shareholders' investments and its likelihood of success must be considered in light of the early stage of its operations.

#### Negative Cash Flow for the Foreseeable Future
The Company has no history of earnings or cash flow from operations. The Company does not expect to generate material revenue or achieve self-sustaining operations for several years, if at all. To the extent that the Company will have negative cash flow in future periods, it will need to allocate a portion of its cash reserves to fund such negative cash flow.

**Reliance on Management**

The success of the Company is dependent upon the ability, expertise, judgment, discretion and good faith of its management. While employment agreements are customarily used as a primary method of retaining the services of key employees, those agreements cannot assure the continued services of such employees. Any loss of the services of such individuals could have a material adverse effect on the Company's business, operating results and/or financial condition.

#### Clinical trials for potential drug candidates are expensive and time consuming, and their outcomes are uncertain.
Before the Company can obtain regulatory approval for the commercial sale of any drug candidate or attract major pharmaceutical companies with which to collaborate, it will be required to complete extensive clinical trials to demonstrate the safety and efficacy of its drug candidates. Clinical trials are expensive and are difficult to design and implement. The clinical trial process is time-consuming and can often be subject to unexpected delays. These delays relate to various causes, including but not limited to: inability to manufacture or obtain sufficient quantities of materials for use in clinical trials; delays arising from collaborative partnerships; delays in obtaining regulatory approvals to commence a study, or government intervention to suspend or terminate a study; delays, suspensions or termination of clinical trials by the applicable institutional review board or independent ethics board responsible for overseeing the study to protect research subjects; delays in identifying and reaching agreement on acceptable terms with prospective clinical trial sites; slow rates of patient recruitment and enrollment; uncertain dosing issues; inability or unwillingness of medical investigators to follow clinical protocols; variability in the number and types of subjects available for each study and resulting difficulties in identifying and enrolling subjects who meet trial eligibility criteria; scheduling conflicts; difficulty in maintaining contact with subjects after treatment resulting in incomplete data; unforeseen safety issues or side effects; lack of efficacy during clinical trials; reliance on clinical research organizations to efficiently and properly conduct clinical trials in accord with contracted arrangements and regulations or other regulatory delays.

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|:---|:---|
| ![](logo.jpg) | 20 |

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#### Risks Related to Food and Drug Administration (FDA) Approval
In the United States, the FDA regulates the approval of therapeutics and the FDA notification and approval process requires substantial time, effort and financial resources to navigate. The Company cannot be certain that any approvals for its products will be granted on a timely basis, if at all. Other jurisdictions outside of the US have similar government regulatory bodies and requirements that the Company must meet prior to selling products in those jurisdictions.

The Company faces risks, expenses, shifts, changes and difficulties as do all companies whose businesses are regulated by various federal, state and local governments. The regulatory environment is ever changing particularly under the current US administration, the full impact of which is not yet understood. Changing regulations and any failure to follow applicable regulatory requirements will have a materially negative impact on the business of the Company. Furthermore, future changes in legislation cannot be predicted and could irreparably harm the business of the Company.

#### Intellectual Property Rights
The Company could be adversely affected if it does not adequately protect its intellectual property. The Company regards its marks, rights, and trade secrets and other intellectual property as critical to its success. To protect its investments and the Company's intellectual property, it may rely on a combination of patents, trademark and copyright law, trade secret protection and confidentiality agreements and other contractual arrangements with its employees, clients, strategic partners, acquisition targets and others. There can be no assurance that the steps taken by the Company to protect its Intellectual Property will be adequate or that third parties will not infringe or misappropriate the Company's copyrights, trademarks and similar proprietary rights, or that the Company will be able to detect unauthorized use of its Intellectual Property and take appropriate steps to enforce its rights. In addition, although the Company believes that its Intellectual Property does not infringe on the intellectual property rights of others, there can be no assurance that other parties will not assert infringement claims against the Company. Such claims, even if not meritorious, could result in the expenditure of significant financial and managerial resources.

The Company will rely on trade secrets to protect technology where it does not believe patent protection is appropriate or obtainable. Trade secrets are difficult to protect. While commercially reasonable efforts to protect trade secrets will be used, strategic partners, employees, consultants, contractors or scientific and other advisors may unintentionally or willfully disclose information to competitors.

If the Company is not able to defend patents or trade secrets, then it will not be able to exclude competitors from developing or marketing competing products, and the Company may not generate enough revenue from product sales to justify the cost of development of those products and to achieve or maintain profitability.

#### The results of preclinical and non-pivotal clinical trials are not necessarily predictive of future favorable results.
Preclinical tests and early clinical trials are primarily designed to test the safety and to understand the side effects of drug candidates and to explore efficacy at various doses and schedules. Success in preclinical or animal studies and early clinical trials does not ensure that later large-scale efficacy trials will be successful nor does it predict final results. Favorable results in early trials may not be repeated in later ones.

#### Difficulty to Forecast
The Company must rely largely on its own market research to forecast sales as detailed forecasts are not generally obtainable from other sources. A failure in the demand for its products to materialize as a result of competition, technological change, or other factors could have a materially adverse effect on the business, results of operations and financial condition of the Company.

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|:---|:---|
| ![](logo.jpg) | 21 |

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#### Litigation
The Company may become party to litigation from time to time in the ordinary course of business which could adversely affect its business. Should any litigation in which the Company becomes involved be determined against the Company, such a decision could adversely affect the Company's ability to continue operating and could adversely affect the market price of the Company's common shares. Even if the Company is involved in litigation and wins, litigation can redirect significant Company resources.

Commercial success of the Company will depend in part on not infringing the patents and proprietary rights of other parties, and on enforcing its own patents and proprietary rights against others. The Company's research and development programs are in highly competitive fields in which numerous third parties have issued patents and pending patent applications with claims closely related to the subject matter of the Company's programs. The Company is not currently aware of any Intellectual Property related litigation or other proceedings or claims by third parties regarding its technologies or methods.

While it is the practice of the Company to undertake pre-filing searches and analyses of developing technologies, it cannot guarantee that it has identified every patent or patent application that may be relevant to the research, development, or commercialization of its products. Moreover, it cannot assure that third parties will not assert invalid, erroneous, or frivolous patent infringement claims.

#### Uninsurable Risks
The business of the Company may not be insurable or, insurance may not be purchased due to high cost. Should non-insured liabilities arise, they could reduce or eliminate any future profitability and result in increasing costs and a decline in the value of the Company.

#### The market price of the Company's common shares may be subject to wide fluctuations.
The market price of the Company's common shares may be subject to wide fluctuations in response to many factors, including variability in the operating results of the Company, divergence in financial results from analysts' expectations, changes in earnings estimates by stock market analysts, changes in the business prospects of the Company, general economic conditions, legislative changes, and other events and factors outside of the Company's control. In addition, stock markets have from time-to-time experienced extreme price and volume fluctuations, which, as well as general economic and political conditions, could adversely affect the market price of the Company's common shares.

#### Dividends
The Company has no earnings or dividend record and does not anticipate paying any dividends on the common shares in the foreseeable future.

#### Dilution
The financial risk of the Company's future activities will be borne to a significant degree by purchasers of common shares. If the Company issues common shares from its treasury for financing purposes, purchasers will suffer additional dilution and control of the Company could change.

#### Rapid Technological Change
The business of the Company is subject to rapid technological changes. Failure to keep up with such changes may adversely affect the business of the Company. The Company is subject to the risks of companies operating in the medical and healthcare business. The market in which the Company competes is characterized by rapidly changing technology, evolving industry standards, frequent new service and product announcements, introductions and enhancements, and changing customer demands. As a result, an investment in shares of the Company is highly speculative and is only suitable for investors who recognize the high risks involved and can afford a total loss of their investment.

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|:---|:---|
| ![](logo.jpg) | 22 |

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#### Risks Associated with Acquisitions
If appropriate opportunities present themselves, the Company may acquire businesses, technologies, services or products that the Company believes are strategic. The Company currently has no understandings, commitments or agreements with respect to any other material acquisition and no other material acquisition is currently being pursued. There can be no assurance that the Company will be able to identify, negotiate or finance future acquisitions successfully, or to integrate such acquisitions with its current business. The process of integrating an acquired business, technology, service or product into the Company may result in unforeseen operating difficulties and expenditures and may absorb significant management attention that would otherwise be available for ongoing development of the Company's business. Future acquisitions could result in potentially dilutive issuances of equity securities, the incurrence of debt, contingent liabilities and/or amortization expenses related to goodwill and other intangible assets, which could materially adversely affect the Company's business, results of operations and financial condition. Any such future acquisitions of other businesses, technologies, services or products might require the Company to obtain additional equity or debt financing, which might not be available on terms favorable to the Company, or at all, and such financing, if available, might be dilutive.

#### Economic Environment
The Company's operations could be affected by the economic environment should the unemployment level, interest rates or inflation reach levels that influence consumer trends and consequently, impact the Company's future sales and profitability.

#### Global Economy Risk
The ongoing economic problems and downturn of global capital markets has generally made the raising of capital by equity or debt financing more difficult. Access to financing has been negatively impacted by the ongoing global economic risks. As such, the Company is subject to liquidity risks in meeting its development and future operating cost requirements. These factors may impact the Company's ability to raise equity or obtain loans and other credit facilities in the future and on terms favorable to the Company. If uncertain market conditions persist, the Company's ability to raise capital could be jeopardized which could have an adverse impact on the Company's operations and the trading price of the Company's common shares.

#### International Conflict
The continued impacts from the Russian invasion of Ukraine, the collapse of financial institutions such as the Silicon Valley Bank, the political and economic uncertainty under the new Trump administration in the U.S., and the resulting inflation and interest rate measures experienced globally, as well as the effects of certain countermeasures taken by central banks may adversely affect the Company. In particular, there continues to exist significant uncertainty about the future relationship between the US and other countries (including Canada) with respect to trade policies, treaties and tariffs and global stock markets have experienced great volatility. These developments, or the perception that any of them could occur, may have a material adverse effect on global economic conditions and the stability of global financial markets, and may significantly reduce global trade and, in particular, trade between the impacted nations and the US. Any of these factors may have a negative impact on the global or Canadian economy, and on the Company's business, financial condition, and results of operations.

#### Financial Risk Exposures
The Company may have financial risk exposure to varying degrees relating to the currency of each of the countries where it operates. The level of the financial risk exposure related to currency and exchange rate fluctuations will depend on the Company's ability to hedge such risk or other protection mechanisms.

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|:---|:---|
| ![](logo.jpg) | 23 |

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#### Attracting and keeping senior management and key scientific personnel
The success of the Company depends on the continued ability to attract, retain, and motivate highly qualified management, clinical, and scientific personnel and to develop and maintain important relationships with leading academic institutions, companies, and thought leaders. Allen Davidoff, the Company's CEO, exercises significant control over the day-to-day affairs of the Company. The Company depends on Dr. Davidoff to engage with third parties and contractors to operate the business.

#### SEGMENT REPORTING
We view our operations and manage our business in one segment, which is the development and commercialization of biopharmaceuticals, initially focused on the treatment of gout and progressive kidney disease.

#### TREND INFORMATION
Other than as disclosed elsewhere, we are not aware of any trends, uncertainties, demands, commitments, or events that are reasonably likely to have a material effect on our net revenues, income from continuing operations, profitability, liquidity or capital resources, or that would cause reported financial information not necessarily to be indicative of future operating results or financial condition.

#### MANAGEMENT'S RESPONSIBILITY FOR FINANCIAL STATEMENTS
The Company's management is responsible for the presentation and preparation of the financial statements and the MD&A. The MD&A has been prepared in accordance with the requirements of securities regulators, including National Instrument 51-102 of the Canadian Securities Administrators.

The financial statements and information in the MD&A necessarily include amounts based on informed judgments and estimates of the expected effects of current events and transactions with appropriate consideration to materiality. In addition, in preparing the financial information, we must interpret the requirements described above, make determinations as to the relevancy of information included, and make estimates and assumptions that affect reported information. The MD&A also includes information regarding the impact of current transactions and events, sources of liquidity and capital resources, operating trends, risks and uncertainties. Actual results in the future may differ materially from our present assessment of this information because future events and circumstances may not occur as anticipated.

#### INTERNAL CONTROLS OVER FINANCIAL REPORTING
**Disclosure controls and procedures**

Disclosure controls and procedures are designed to provide reasonable assurance that information required to be disclosed by the Company in its annual filings, interim filings, or other reports filed or submitted by it under securities legislation is recorded, processed, summarized, and reported within the time periods specified in the securities legislation and include controls and procedures designed to ensure that information required to be disclosed by the Company in its annual filings, interim filings or other reports filed or submitted under securities legislation is accumulated and communicated to the Company's management, including its Chief Executive Officer and Chief Financial Officer, as appropriate to allow timely decisions regarding required disclosure.

**Internal controls over financial reporting**

Management designs and implements internal controls over financial reporting to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements in accordance with IFRS.

The Company's internal controls over financial reporting include policies and procedures that pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and disposition of assets; provide reasonable assurance that transactions are recorded as necessary to permit preparation of the financial statements in accordance with IFRS and that receipts and expenditures are being made only in accordance with the authorization of management and directors of the Company; and provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use or disposition of assets that could have a material effect on the financial statements.

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|:---|:---|
| ![](logo.jpg) | 24 |

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As at December 31, 2025, there has not been any material change to disclosure controls and procedures and internal controls over financial reporting for the period other than the weakness mitigating steps discussed below. Management, including the Chief Executive Officer and Chief Financial Officer, has evaluated the effectiveness of the design and operation of the Company's disclosure controls and procedures and internal controls over financial reporting. As of December 31, 2025, the Chief Executive Officer and Chief Financial Officer evaluated the effectiveness of the Company's disclosure controls and procedures (DC&P) and internal control over financial reporting (ICFR) and determined they were not effective due to the existence of a material weakness in the period end closing process and related management review controls. While the Company has implemented enhanced control activities to remediate previously identified material weaknesses, such remedial activities have been determined to not yet be operating effectively. The Company is committed to the continuous development of processes to address new weaknesses and mitigate any associated risks moving forward. Readers of this MD&A and associated financial statements should take this into consideration. A material weakness is a deficiency or a combination of control deficiencies in internal control over financial reporting such that there is a reasonable possibility that a material misstatement of annual or interim financial statements will not be prevented or detected on a timely basis. Because of their inherent limitations, internal controls over financial reporting can provide only reasonable assurance and may not prevent or detect misstatements. Furthermore, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate. The control framework used to evaluate the effectiveness of the design and operation of the Company's internal controls over financial reporting is the 2013 Internal Control – *Integrated Framework* published by the Committee of Sponsoring Organizations of the Treadway Commission.

**Changes in Internal Control Over Financial Reporting**

There has been no change in the Company's design of internal controls and procedures over financial reporting that has materially affected, or is reasonably likely to materially affect, the Company's internal control over financial reporting during the period covered by this MD&A, other than the work done to address the identified material weaknesses as discussed above.

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|:---|:---|
| ![](logo.jpg) | 25 |

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