# EDGAR Filing Document

**Accession Number:** 0001710340
**File Stem:** 0001493152-23-002061
**Filing Date:** 2023-1
**Character Count:** 9702
**Document Hash:** 364a8bba9c8df5aabd46732f4ae4c8e6
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001493152-23-002061.hdr.sgml**: 20230120

**ACCESSION NUMBER**: 0001493152-23-002061

**CONFORMED SUBMISSION TYPE**: SC 13G/A

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20230120

**DATE AS OF CHANGE**: 20230120

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Eton Pharmaceuticals, Inc.
- **CENTRAL INDEX KEY:** 0001710340
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 371858472
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G/A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-90726
- **FILM NUMBER:** 23541621

**BUSINESS ADDRESS:**
- **STREET 1:** 21925 W. FIELD PARKWAY
- **STREET 2:** SUITE 235
- **CITY:** DEER PARK
- **STATE:** IL
- **ZIP:** 60010-7278
- **BUSINESS PHONE:** (847) 787-7361

**MAIL ADDRESS:**
- **STREET 1:** 21925 W. FIELD PARKWAY
- **STREET 2:** SUITE 235
- **CITY:** DEER PARK
- **STATE:** IL
- **ZIP:** 60010-7278
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Opaleye Management Inc.
- **CENTRAL INDEX KEY:** 0001595855
- **IRS NUMBER:** 205648796
- **STATE OF INCORPORATION:** MA
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G/A

**BUSINESS ADDRESS:**
- **STREET 1:** ONE BOSTON PLACE
- **STREET 2:** SUITE 2600
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02108
- **BUSINESS PHONE:** 617-904-9195

**MAIL ADDRESS:**
- **STREET 1:** ONE BOSTON PLACE
- **STREET 2:** SUITE 2600
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02108

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**SCHEDULE 13G/A**

**Under the Securities Exchange Act of 1934**

**(Amendment No. <u>5</u>)\***

**ETON PHARMACEUTICALS, INC.**

(Name of Issuer)

Common Stock, par value $0.001 per share

(Title of Class of Securities)

29772L108

(CUSIP Number)

James Silverman, One Boston Place, 26<sup>th</sup> Floor, Boston, MA 02108

(Name, Address and Telephone Number of Person

Authorized to Receive Notices and Communications)

12/31/2022

(Date of Event which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

☐ Rule 13d-1(b)

☐ Rule 13d-1(c)

☐ Rule 13d-1(d)

 

<sup>\*</sup> The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

CUSIP No. 000000000 13G/A Page 2 of 5 Pages

1. NAMES
 OF REPORTING PERSONS Opaleye
Management, Inc. I.R.S.
 IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) 20-5648796

2. CHECK
 THE APPROPRIATE BOX IF A MEMBER OF A GROUP (see
 instructions) (a)
 ☐ (b)
 ☐

3. SEC
USE ONLY

4. CITIZENSHIP
 OR PLACE OF ORGANIZATION Massachusetts

---

| | | |
|:---|:---|:---|
| NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON WITH | 5. | SOLE VOTING POWER<br> 0<br>|
| NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON WITH | 6. | SHARED VOTING POWER<br> 2,170,000<br>|
| NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON WITH | 7. | SOLE DISPOSITIVE POWER<br> 0<br>|
| NUMBER OF<br> SHARES<br> BENEFICIALLY<br> OWNED BY<br> EACH<br> REPORTING<br> PERSON WITH | 8. | SHARED DISPOSITIVE POWER<br> 2,170,000<br>|

---

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| | |
|:---|:---|
| 9. | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<br> 2,170,000 |
| 10. | CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (see instructions)<br> ☐ |
| 11. | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)<br> 8.58% |
| 12. | TYPE OF REPORTING PERSON (see instructions)<br> CO |
|  | \* Based upon 25,297,037 shares of common stock issued and outstanding on October 31, 2022 as reported by the Issuer on its registration statement on Form 10-Q filed with the Securities and Exchange Commission on November 10, 2022. This calculation does not include the exercise or conversion of outstanding securities of the Issuer. |

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CUSIP No. 000000000 13G/A Page 3 of 5 Pages

**Item 1.**

&nbsp;&nbsp;&nbsp;&nbsp;(a) Name
 of Issuer: Eton Pharmaceuticals, Inc. (the "Company").

(b) Address
 of Issuer's Principal Executive Offices: 21925 W. Field Parkway, Suite 235, Deer Park, Illinois 60010

**Item 2.**

&nbsp;&nbsp;&nbsp;&nbsp;(a) Name
 of Person Filing Opaleye, L.P.

(b) Address
 of the Principal Office or, if none, residence One Boston Place, 26<sup>th</sup> Floor, Boston, MA 02108

(c) Citizenship
 is set forth in Row 4 of the cover page for each Reporting Person and is incorporated herein by reference for each such
 Reporting Person.

(d) Title
 of Class of Securities Common Stock, $0.001 par value per share

(e) CUSIP
 Number 29772L108

**Item 3. If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:**

&nbsp;&nbsp;&nbsp;&nbsp;(a) ☐ Broker
 or dealer registered under section 15 of the Act (15 U.S.C. 78o).

(b) ☐ Bank
 as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).

(c) ☐ Insurance
 company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).

(d) ☐ Investment
 company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8).

(e) ☐ An
 investment adviser in accordance with §240.13d-1(b)(1)(ii)(E);

(f) ☐ An
 employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F);

(g) ☐ A
 parent holding company or control person in accordance with §240.13d-1(b)(1)(ii)(G);

(h) ☐ A
 savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);

(i) ☐ A
 church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of
 1940 (15 U.S.C. 80a-3);

(j) ☐ Group,
 in accordance with §240.13d-1(b)(1)(ii)(J).

**Item 4. Ownership.**

Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

(a) Amount beneficially owned: 2,170,000

(b) Percent of class: 8.58%

(c) Number of shares as to which the person has: 2,170,000

(i) Sole power to vote or to direct the vote 0

(ii) Shared power to vote or to direct the vote 2,170,000

(iii) Sole power to dispose or to direct the disposition of .0

CUSIP No. 000000000 13G/A Page 4 of 5 Pages

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) Shared
 power to dispose or to direct the disposition of 2,170,000 \*
 Based upon 24.606,175 shares of common stock issued and outstanding on November 10, 2022 as reported by the Issuer on its registration
 statement on Form 10-Q filed with the Securities and Exchange Commission on November 16, 2022. This calculation does not include
 the exercise or conversion of outstanding securities of the Issuer.

 

*Instruction*. For computations regarding securities which represent a right to acquire an underlying security *see* §240.13d-3(d)(1).

**Item 5. Ownership of Five Percent or Less of a Class.**

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following ☐ .

 

*Instruction*. Dissolution of a group requires a response to this item.

**Item 6. Ownership of More than Five Percent on Behalf of Another Person.** 

Not applicsble

**Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company.**

Not applicable

**Item 8. Identification and Classification of Members of the Group.**

Not applicable

**Item 9. Notice of Dissolution of Group.**

Not applicable

**Item 10. Certification.**

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| | |
|:---|:---|
| (a) | The following certification shall be included if the statement is filed pursuant to §240.13d-1(b): |
|  | By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. |
| (b) | The following certification shall be included if the statement is filed pursuant to §240.13d-1(c): |
|  | By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. |

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CUSIP No. 000000000 13G/A Page 5 of 5 Pages

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

---

| |
|:---|
| 01/20/2023 |
| Date |
| */s/ James Silvermam* |
| Signature |
| Managing Member of Opaleye GP LLC,<br> the General Partner of Opaleye, L.P. |
| Name/Title |

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