# EDGAR Filing Document

**Accession Number:** 0001819113
**File Stem:** 0000000000-23-002362
**Filing Date:** 2023-3
**Character Count:** 3689
**Document Hash:** 123cc6b03a3868b315eb2d970c2e421f
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000000000-23-002362.hdr.sgml**: 20230411

**ACCESSION NUMBER**: 0000000000-23-002362

**CONFORMED SUBMISSION TYPE**: UPLOAD

**PUBLIC DOCUMENT COUNT**: 2

**FILED AS OF DATE**: 20230310

**FILED FOR**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Science 37 Holdings, Inc.
- **CENTRAL INDEX KEY:** 0001819113
- **STANDARD INDUSTRIAL CLASSIFICATION:** SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
- **IRS NUMBER:** 844278203
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** UPLOAD

**BUSINESS ADDRESS:**
- **STREET 1:** 800 PARK OFFICES DRIVE
- **STREET 2:** SUITE 3606
- **CITY:** RESEARCH TRIANGLE PARK
- **STATE:** NC
- **ZIP:** 27709
- **BUSINESS PHONE:** (984) 377-3737

**MAIL ADDRESS:**
- **STREET 1:** 800 PARK OFFICES DRIVE
- **STREET 2:** SUITE 3606
- **CITY:** RESEARCH TRIANGLE PARK
- **STATE:** NC
- **ZIP:** 27709

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Lifesci Acquisition II Corp.
- **DATE OF NAME CHANGE:** 20200723
**PUBLIC REFERENCE ACCESSION NUMBER**: 0001104659-23-028748

## Text-Extract

```

United States securities and exchange commission logo

                           March 10, 2023

       Christine Pellizzari
       Chief Legal and Human Resources Officer
       Science 37 Holdings, Inc.
       800 Park Offices Drive, Suite 3606
       Research Triangle Park, North Carolina 27709

                                                        Re: Science 37
Holdings, Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed March 6, 2023
                                                            File No. 333-270285

       Dear Christine Pellizzari:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Jessica
Ansart at 202-551-4511 with any questions.

                           Sincerely,

                           Division of Corporation Finance

                           Office of Industrial Applications and

                           Services
       cc:                                              Jurgita Ashley

```

### Attached PDF Documents

**Attachment 1:** `filename1`

![img-0.jpeg](img-0.jpeg)

DIVISION OF
CORPORATION FINANCE

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

March 10, 2023

Christine Pellizzari
Chief Legal and Human Resources Officer
Science 37 Holdings, Inc.
800 Park Offices Drive, Suite 3606
Research Triangle Park, North Carolina 27709

**Re: Science 37 Holdings, Inc.**
**Registration Statement on Form S-3**
**Filed March 6, 2023**
**File No. 333-270285**

Dear Christine Pellizzari:

This is to advise you that we have not reviewed and will not review your registration statement.

Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff.

Please contact Jessica Ansart at 202-551-4511 with any questions.

Sincerely,

Division of Corporation Finance
Office of Industrial Applications and
Services

cc: Jurgita Ashley