# EDGAR Filing Document

**Accession Number:** 0001811115
**File Stem:** 0001213900-25-067774
**Filing Date:** 2025-7
**Character Count:** 4918
**Document Hash:** 6644abceeb38abb1e9f98e6e4c947ff1
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001213900-25-067774.hdr.sgml**: 20250725

**ACCESSION NUMBER**: 0001213900-25-067774

**CONFORMED SUBMISSION TYPE**: S-8 POS

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20250725

**DATE AS OF CHANGE**: 20250725

**EFFECTIVENESS DATE**: 20250725

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Renalytix plc
- **CENTRAL INDEX KEY:** 0001811115
- **STANDARD INDUSTRIAL CLASSIFICATION:** SERVICES-MEDICAL LABORATORIES [8071]
- **ORGANIZATION NAME:** 08 Industrial Applications and Services
- **EIN:** 000000000
- **STATE OF INCORPORATION:** X0
- **FISCAL YEAR END:** 0630

**FILING VALUES:**
- **FORM TYPE:** S-8 POS
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-274732
- **FILM NUMBER:** 251152015

**BUSINESS ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** FINSGATE
- **STREET 2:** 5-7 CRANWOOD STREET
- **CITY:** LONDON
- **PROVINCE COUNTRY:** X0
- **BUSINESS PHONE:** 44 29 2071 0570

**MAIL ADDRESS:**
- **ADDRESS IS A NON US LOCATION:** YES
- **STREET 1:** FINSGATE
- **STREET 2:** 5-7 CRANWOOD STREET
- **CITY:** LONDON
- **PROVINCE COUNTRY:** X0

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Renalytix AI plc
- **DATE OF NAME CHANGE:** 20200430

**Registration No. 333-274732**

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**POST-EFFECTIVE AMENDMENT NO. 1**

**TO**

**FORM S-8**

**REGISTRATION STATEMENT**

**UNDER**

**THE SECURITIES ACT OF 1933**

**Renalytix plc**

(Exact name of registrant as specified in its charter)

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| | |
|:---|:---|
| **England and Wales** | **Not applicable** |
| (State or other jurisdiction of incorporation) | (I.R.S. Employer Identification No.) |

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| |
|:---|
| **2 Leman Street**<br> **London E1W 9US**<br> **United Kingdom** |
| (Address of principal executive offices) (Zip Code) |

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| |
|:---|
| **Renalytix AI plc 2020 Employee Share Purchase Plan**<br> **Renalytix AI plc 2020 Equity Incentive Plan** |
| (Full title of the plan) |

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| |
|:---|
| &nbsp;&nbsp; **Renalytix AI, Inc.**<br> **1460 Broadway**<br> **New York, NY 10036**<br> **Tel: +1 646 397 3970** |
| &nbsp;&nbsp;(Name, address and telephone number, including area code, of agent for service) |
| &nbsp;&nbsp;*Copies to:* |
| &nbsp;&nbsp;**Mark E. Rosenstein** |
| &nbsp;&nbsp;**Derick S. Kauffman** |
| &nbsp;&nbsp;**Stevens & Lee, P.C.** |
| &nbsp;&nbsp;**620 Freedom Business Center, Suite 200** |
| &nbsp;&nbsp;**King of Prussia, PA 19406** |
| &nbsp;&nbsp;**(610) 205-6000** |

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Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

Large accelerated filer ☐ Accelerated filer ☐ Non-accelerated filer ☒ <br> Smaller reporting company ☒ Emerging growth company ☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

**This Registration Statement shall become effective upon filing in accordance with Rule 464 promulgated under the Securities Act of 1933, as amended.**

**DEREGISTRATION OF SHARES**

Renalytix plc (the "Company") is filing this Post-Effective Amendment No. 1 to the Registration Statement on Form S-8 (File No. 333-274732) (the "Registration Statement"), to deregister the offer of the ordinary shares, nominal value £0.0025 per ordinary share, of the Company, registered under the Registration Statement that remain unissued under each of the Renalytix AI plc 2020 Employee Share Purchase Plan, and Renalytix AI plc 2020 Equity Incentive Plan.

The Registration Statement is hereby amended, as appropriate, to reflect the deregistration of such securities and the Company hereby terminates the effectiveness of the Registration Statement.

**SIGNATURES**

**The Registrant.** Pursuant to the requirements of the Securities Exchange Act of 1933, as amended, the Registrant certifies that is has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of London, United Kingdom, on July 25, 2025.

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| | |
|:---|:---|
| RENALYTIX PLC | RENALYTIX PLC |
| /s/ James McCullough | /s/ James McCullough |
| Name: | James McCullough |
| Title: | Chief Executive Officer and Director |

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No other person is required to sign this Post-Effective Amendment to the Registration Statement in reliance on Rule 478 of the Securities Act of 1933, as amended.