# EDGAR Filing Document

**Accession Number:** 0001224962
**File Stem:** 0001224962-25-000003
**Filing Date:** 2025-8
**Character Count:** 43533
**Document Hash:** f96eca350d64aa438809a7c4cb0f533b
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001224962-25-000003.hdr.sgml**: 20250821

**ACCESSION NUMBER**: 0001224962-25-000003

**CONFORMED SUBMISSION TYPE**: N-PX

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20250630

**FILED AS OF DATE**: 20250821

**EFFECTIVENESS DATE**: 20250821

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** PERCEPTIVE ADVISORS LLC
- **CENTRAL INDEX KEY:** 0001224962

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** N-PX
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-10438
- **FILM NUMBER:** 251239280

**BUSINESS ADDRESS:**
- **STREET 1:** 51 ASTOR PLACE, 10TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10003
- **BUSINESS PHONE:** 646-205-5300

**MAIL ADDRESS:**
- **STREET 1:** 51 ASTOR PLACE, 10TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10003

## FORM N-PX
### ANNUAL REPORT OF PROXY VOTING RECORD

## N-PX: Filer Information

**Filer CIK:** 0001224962

**Date of Report:** 06/30/2025

**Are you a Registered Management Investment Company or an Institutional Manager?:** Institutional Manager

**Is this a LIVE or TEST Filing?:** LIVE

**Is this an electronic copy of an official filing submitted in paper format?:** [ ]

### Submission Contact Information
_Not provided in this filing._

### Notification Information
**Notify via Filing Website only?:** [ ]

## N-PX: Cover Page

**Name of reporting person:** PERCEPTIVE ADVISORS LLC

**Address:** 51 ASTOR PLACE, 10TH FLOOR, NEW YORK, NY 10003

**Telephone number:** 646-205-5345

**Name of agent for service:** —

**Agent Address:** —, —, — —

**Reporting Period:** Report for the year ended 06/30/2025

**SEC File Number:** 028-10438

**CRD Number (if any):** —

**Other SEC File Number (if any):** —

**LEI (if any):** —

**Report Type (check only one):**

Institutional Manager.

- [x] Institutional Manager Voting Report

- [ ] Institutional Manager Notice Report

- [ ] Institutional Manager Combination Report

Registered Management Investment Company.

- [ ] Fund Voting Report

- [ ] Fund Notice Report

**Do you wish to provide explanatory information pursuant to Special Instruction B.4?:**

- [x] No

- [ ] Yes

**Additional information:** —

## N-PX: Summary - Included Managers

**Number of Included Institutional Managers:** 0

**Included Institutional Managers:** —

## FORM N-PX PROXY VOTING RECORD

| NAME OF ISSUER                       | CUSIP     | MEETING DATE   | VOTE DESCRIPTION                                                                                                                                                                                                                                                                                                            | VOTE CATEGORY                |   SHARES VOTED |   SHARES ON LOAN | HOW VOTED   |   SHARES VOTED FOR OR AGAINST MANAGEMENT | FOR OR AGAINST MANAGEMENT   | OTHER INFO   |
|:---|:---|:---|:---|:---|---:|---:|:---|---:|:---|:---|
| ADAPTIVE BIOTECHNOLOGIES CORPORATION | 00650F109 | 06/10/2025     | TO APPROVE, ON A NON-BINDING ADVISORY BASIS, THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS AS DESCRIBED IN THE PROXY STATEMENT.                                                                                                                                                                                          | SECTION 14A SAY-ON-PAY VOTES |            518 |                0 | FOR         |                                      518 | FOR                         |  |
| ADMA BIOLOGICS, INC.                 | 000899104 | 06/04/2025     | TO APPROVE, ON A NON-BINDING, ADVISORY BASIS, THE COMPENSATION OF THE COMPANY'S NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                   | SECTION 14A SAY-ON-PAY VOTES |         935021 |                0 | FOR         |                                   935021 | FOR                         |  |
| ADMA BIOLOGICS, INC.                 | 000899104 | 06/04/2025     | TO DETERMINE, ON A NON-BINDING, ADVISORY BASIS, THE FREQUENCY OF FUTURE ADVISORY VOTES ON THE COMPENSATION OF THE COMPANY'S NAMED EXECUTIVE OFFICERS.                                                                                                                                                                       | SECTION 14A SAY-ON-PAY VOTES |         935021 |                0 | FOR         |                                   935021 | FOR                         |  |
| AKERO THERAPEUTICS, INC              | 00973Y108 | 06/03/2025     | TO CONSIDER AND ACT UPON A NON-BINDING, ADVISORY VOTE TO APPROVE THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                          | SECTION 14A SAY-ON-PAY VOTES |         673795 |                0 | FOR         |                                   673795 | FOR                         |  |
| ALDEYRA THERAPEUTICS, INC.           | 01438T106 | 06/10/2025     | TO APPROVE, ON A NON-BINDING, ADVISORY BASIS, THE COMPENSATION OF ALDEYRA THERAPEUTICS, INC.'S NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                    | SECTION 14A SAY-ON-PAY VOTES |        2994479 |                0 | FOR         |                                  2994479 | FOR                         |  |
| AMICUS THERAPEUTICS, INC.            | 03152W109 | 06/05/2025     | APPROVAL, ON AN ADVISORY BASIS, THE COMPANY'S EXECUTIVE COMPENSATION.                                                                                                                                                                                                                                                       | SECTION 14A SAY-ON-PAY VOTES |       16381751 |                0 | FOR         |                                 16381751 | FOR                         |  |
| AMYLYX PHARMACEUTICALS, INC.         | 03237H101 | 06/05/2025     | TO APPROVE, ON A NON-BINDING, ADVISORY BASIS, THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                             | SECTION 14A SAY-ON-PAY VOTES |        7920474 |                0 | FOR         |                                  7920474 | FOR                         |  |
| APELLIS PHARMACEUTICALS INC.         | 03753U106 | 06/03/2025     | TO HOLD AN ADVISORY VOTE TO APPROVE THE COMPENSATION PAID TO OUR NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                                  | SECTION 14A SAY-ON-PAY VOTES |          41477 |                0 | FOR         |                                    41477 | FOR                         |  |
| APELLIS PHARMACEUTICALS INC.         | 03753U106 | 06/03/2025     | TO HOLD AN ADVISORY VOTE ON THE FREQUENCY OF FUTURE ADVISORY VOTES ON THE COMPENSATION PAID TO OUR NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                | SECTION 14A SAY-ON-PAY VOTES |          41477 |                0 | FOR         |                                    41477 | FOR                         |  |
| APOGEE THERAPEUTICS, INC.            | 03770N101 | 06/17/2025     | VOTE ON THE FREQUENCY OF FUTURE ADVISORY VOTES TO APPROVE OUR NAMED EXECUTIVE OFFICERS' COMPENSATION.                                                                                                                                                                                                                       | SECTION 14A SAY-ON-PAY VOTES |         692176 |                0 | FOR         |                                   692176 | FOR                         |  |
| APPLIED THERAPEUTICS, INC.           | 03828A101 | 06/09/2025     | TO APPROVE (ON A NO-BINDING ADVISORY BASIS) THE FREQUENCY OF AN ADVISORY VOTE ON THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS IN FUTURE YEARS.                                                                                                                                                                          | SECTION 14A SAY-ON-PAY VOTES |         860000 |                0 | FOR         |                                   860000 | FOR                         |  |
| APPLIED THERAPEUTICS, INC.           | 03828A101 | 06/09/2025     | TO APPROVE (ON A NO-BINDING ADVISORY BASIS) THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS AS DESCRIBED IN THE ACCOMPANYING MATERIALS.                                                                                                                                                                                    | SECTION 14A SAY-ON-PAY VOTES |         860000 |                0 | FOR         |                                   860000 | FOR                         |  |
| AQUESTIVE THERAPEUTICS, INC.         | 03843E104 | 06/11/2025     | TO APPROVE, ON A NON-BINDING ADVISORY BASIS, THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                              | SECTION 14A SAY-ON-PAY VOTES |        2949266 |                0 | FOR         |                                  2949266 | FOR                         |  |
| ARCELLX, INC.                        | 03940C100 | 05/28/2025     | TO APPROVE, ON AN ADVISORY BASIS, THE COMPENSATION OF THE NAMED EXECUTIVE OFFICERS IDENTIFIED IN THE 2024 SUMMARY COMPENSATION TABLE IN THE "EXECUTIVE COMPENSATION" SECTION OF THE PROXY STATEMENT.                                                                                                                        | SECTION 14A SAY-ON-PAY VOTES |        1697083 |                0 | FOR         |                                  1697083 | FOR                         |  |
| ARTIVION, INC.                       | 228903100 | 05/13/2025     | TO APPROVE, BY NON-BINDING VOTE, THE COMPENSATION PAID TO ARTIVION'S NAMED EXECUTIVE OFFICERS, AS DISCLOSED PURSUANT TO ITEM 402 OF REGULATION S-K, INCLUDING THE COMPENSATION DISCUSSION AND ANALYSIS, COMPENSATION TABLES, AND NARRATIVE DISCUSSION.                                                                      | SECTION 14A SAY-ON-PAY VOTES |        1806571 |                0 | FOR         |                                  1806571 | FOR                         |  |
| ASTRIA THERAPEUTICS, INC.            | 04635X102 | 06/11/2025     | THE APPROVAL, BY NON-BINDING ADVISORY VOTE, OF OUR EXECUTIVE COMPENSATION.                                                                                                                                                                                                                                                  | SECTION 14A SAY-ON-PAY VOTES |        6319480 |                0 | FOR         |                                  6319480 | FOR                         |  |
| AVALO THERAPEUTICS INC               | 05338F306 | 06/17/2025     | TO APPROVE, ON A NONBINDING ADVISORY BASIS, A "SAY-ON-PAY" RESOLUTION REGARDING THE COMPENSENSATION OF OUR NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                        | SECTION 14A SAY-ON-PAY VOTES |         195497 |                0 | FOR         |                                   195497 | FOR                         |  |
| AXSOME THERAPEUTICS, INC.            | 05464T104 | 06/06/2025     | TO APPROVE, BY NON-BINDING ADVISORY VOTE, THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                                 | SECTION 14A SAY-ON-PAY VOTES |           2071 |                0 | FOR         |                                     2071 | FOR                         |  |
| CELCUITY INC.                        | 15102K100 | 05/13/2025     | TO APPROVE, BY A NON-BINDING AND ADVISORY VOTE, COMPENSATION OF THE NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                               | SECTION 14A SAY-ON-PAY VOTES |        2128723 |                0 | FOR         |                                  2128723 | FOR                         |  |
| CULLINAN THERAPEUTICS, INC.          | 230031106 | 06/12/2025     | PROPOSAL TO VOTE, ON AN ADVISORY BASIS, TO APPROVE OUR NAMED EXECUTIVE OFFICER COMPENSATION.                                                                                                                                                                                                                                | SECTION 14A SAY-ON-PAY VOTES |           1798 |                0 | FOR         |                                     1798 | FOR                         |  |
| CULLINAN THERAPEUTICS, INC.          | 230031106 | 06/12/2025     | PROPOSAL TO VOTE, ON AN ADVISORY BASIS, ON THE FREQUENCY OF FUTURE ADVISORY VOTES ON OUR NAMED EXECUTIVE OFFICER COMPENSATION.                                                                                                                                                                                              | SECTION 14A SAY-ON-PAY VOTES |           1798 |                0 | FOR         |                                     1798 | FOR                         |  |
| DELCATH SYSTEMS, INC.                | 24661P807 | 05/15/2025     | TO APPROVE, ON A NON-BINDING ADVISORY BASIS, THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS AS DISCLOSED IN THE ACCOMPANYING PROXY STATEMENT ("PROXY STATEMENT").                                                                                                                                                         | SECTION 14A SAY-ON-PAY VOTES |         422763 |                0 | FOR         |                                   422763 | FOR                         |  |
| DEXCOM, INC.                         | 252131107 | 05/08/2025     | TO PROVIDE A NON-BINDING ADVISORY VOTE ON THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS FOR THE FISCAL YEAR ENDED DECEMBER 31, 2024.                                                                                                                                                                                     | SECTION 14A SAY-ON-PAY VOTES |          54463 |                0 | FOR         |                                    54463 | FOR                         |  |
| DYNE THERAPEUTICS, INC.              | 26818M108 | 05/30/2025     | TO VOTE, ON AN ADVISORY BASIS, TO APPROVE THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                                 | SECTION 14A SAY-ON-PAY VOTES |        1908533 |                0 | FOR         |                                  1908533 | FOR                         |  |
| DYNE THERAPEUTICS, INC.              | 26818M108 | 05/30/2025     | TO HOLD AN ADVISORY VOTE ON THE FREQUENCY OF FUTURE ADVISORY VOTES ON THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                     | SECTION 14A SAY-ON-PAY VOTES |        1908533 |                0 | FOR         |                                  1908533 | FOR                         |  |
| EDGEWISE THERAPEUTICS INC            | 28036F105 | 06/13/2025     | CONDUCT AN ADVISORY VOTE ON THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                                               | SECTION 14A SAY-ON-PAY VOTES |        4589244 |                0 | FOR         |                                  4589244 | FOR                         |  |
| EDGEWISE THERAPEUTICS INC            | 28036F105 | 06/13/2025     | CONDUCT AN ADVISORY VOTE ON THE FREQUENCY OF FUTURE ADVISORY VOTES ON THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                     | SECTION 14A SAY-ON-PAY VOTES |        4589244 |                0 | FOR         |                                  4589244 | FOR                         |  |
| ENVVENO MEDICAL CORPORATION          | 29415J106 | 12/18/2024     | TO APPROVE ON A NON-BINDING, ADVISORY BASIS THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                               | SECTION 14A SAY-ON-PAY VOTES |         522187 |                0 | FOR         |                                   522187 | FOR                         |  |
| ENVVENO MEDICAL CORPORATION          | 29415J106 | 12/18/2024     | TO SELECT ON A NON-BINDING, ADVISORY BASIS THE FREQUENCY OF CONDUCTING FUTURE STOCKHOLDER ADVISORY VOTES ON NAMED EXECUTIVE OFFICER COMPENSATION.                                                                                                                                                                           | SECTION 14A SAY-ON-PAY VOTES |         522187 |                0 | FOR         |                                   522187 | FOR                         |  |
| EVOLUS, INC.                         | 30052C107 | 06/05/2025     | APPROVAL OF, ON AN ADVISORY BASIS, THE COMPENSATION OF EVOLUS' NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                                    | SECTION 14A SAY-ON-PAY VOTES |        4034027 |                0 | FOR         |                                  4034027 | FOR                         |  |
| EXACT SCIENCES CORPORATION           | 30063P105 | 06/12/2025     | TO APPROVE, ON AN ADVISORY BASIS, THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                                         | SECTION 14A SAY-ON-PAY VOTES |            370 |                0 | FOR         |                                      370 | FOR                         |  |
| IMMUNOVANT INC                       | 45258J102 | 08/12/2024     | TO APPROVE, ON A NON-BINDING, ADVISORY BASIS, THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                             | SECTION 14A SAY-ON-PAY VOTES |           1191 |                0 | FOR         |                                     1191 | FOR                         |  |
| INSMED INCORPORATED                  | 457669307 | 05/15/2025     | AN ADVISORY VOTE ON THE 2024 COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                                                  | SECTION 14A SAY-ON-PAY VOTES |           1160 |                0 | FOR         |                                     1160 | FOR                         |  |
| INSULET CORPORATION                  | 45784P101 | 05/22/2025     | TO APPROVE, ON A NON-BINDING, ADVISORY BASIS, THE COMPENSATION OF CERTAIN EXECUTIVE OFFICERS.                                                                                                                                                                                                                               | SECTION 14A SAY-ON-PAY VOTES |          27147 |                0 | FOR         |                                    27147 | FOR                         |  |
| INTRA-CELLULAR THERAPIES, INC.       | 46116X101 | 03/27/2025     | TO APPROVE, ON AN ADVISORY (NON-BINDING) BASIS, THE COMPENSATION THAT MAY BE PAID OR BECOME PAYABLE TO ITI'S NAMED EXECUTIVE OFFICERS THAT IS BASED ON OR OTHERWISE RELATES TO THE MERGER AGREEMENT AND THE TRANSACTIONS CONTEMPLATED BY THE MERGER AGREEMENT.                                                              | SECTION 14A SAY-ON-PAY VOTES |         760674 |                0 | FOR         |                                   760674 | FOR                         |  |
| INTUITIVE SURGICAL, INC.             | 46120E602 | 05/01/2025     | TO APPROVE, BY ADVISORY VOTE, THE COMPENSATION OF THE COMPANY'S NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                                   | SECTION 14A SAY-ON-PAY VOTES |           1289 |                0 | FOR         |                                     1289 | FOR                         |  |
| INVENTIVA SA                         |  | 05/22/2025     | DEFINITIVE APPROVAL OF THE FIXED AND VARIABLE REMUNERATION PAID OR ALLOCATED TO MR. MARK PRUZANSKI AS CHAIRMAN OF THE BOARD OF DIRECTORS FOR<br>THE FINANCIAL YEAR ENDED 31 DECEMBER 2024 (AS OF 13 DECEMBER 2024)                                                                                                          | SECTION 14A SAY-ON-PAY VOTES |        5555555 |                0 | FOR         |                                  5555555 | FOR                         |  |
| INVENTIVA SA                         |  | 05/22/2025     | DEFINITIVE APPROVAL OF THE FIXED AND VARIABLE REMUNERATION PAID OR ALLOCATED TO MR. FREDERIC CREN IN HIS CAPACITY AS CHAIRMAN AND CHIEF<br>EXECUTIVE OFFICER UNTIL 13 DECEMBER 2024 AND AS CHIEF EXECUTIVE OFFICER FROM 13 DECEMBER 2024 IN RESPECT OF THE FINANCIAL YEAR ENDED 31<br>DECEMBER 2024                         | SECTION 14A SAY-ON-PAY VOTES |        5555555 |                0 | FOR         |                                  5555555 | FOR                         |  |
| INVENTIVA SA                         |  | 05/22/2025     | DEFINITIVE APPROVAL OF THE FIXED AND VARIABLE REMUNERATION PAID OR ALLOCATED TO MR. PIERRE BROQUA IN HIS CAPACITY AS DEPUTY CHIEF EXECUTIVE<br>OFFICER FOR THE FINANCIAL YEAR ENDED 31 DECEMBER 2024                                                                                                                        | SECTION 14A SAY-ON-PAY VOTES |        5555555 |                0 | FOR         |                                  5555555 | FOR                         |  |
| INVENTIVA SA                         |  | 05/22/2025     | APPROVAL OF THE INFORMATION ON THE REMUNERATION OF CORPORATE OFFICERS CONTAINED IN THE CORPORATE GOVERNANCE REPORT AND REFERRED TO IN<br>SECTION I OF ARTICLE L. 22-10-9 OF THE FRENCH COMMERCIAL CODE                                                                                                                      | SECTION 14A SAY-ON-PAY VOTES |        5555555 |                0 | FOR         |                                  5555555 | FOR                         |  |
| INVENTIVA SA                         |  | 05/22/2025     | APPROVAL OF THE REMUNERATION POLICY FOR MR. MARK PRUZANSKI AS CHAIRMAN OF THE BOARD OF DIRECTORS                                                                                                                                                                                                                            | SECTION 14A SAY-ON-PAY VOTES |        5555555 |                0 | FOR         |                                  5555555 | FOR                         |  |
| INVENTIVA SA                         |  | 05/22/2025     | APPROVAL OF THE REMUNERATION POLICY FOR MR. FREDERIC CREN AS CHIEF EXECUTIVE OFFICER                                                                                                                                                                                                                                        | SECTION 14A SAY-ON-PAY VOTES |        5555555 |                0 | FOR         |                                  5555555 | FOR                         |  |
| INVENTIVA SA                         |  | 05/22/2025     | APPROVAL OF THE REMUNERATION POLICY FOR MR. PIERRE BROQUA AS DEPUTY CHIEF EXECUTIVE OFFICER                                                                                                                                                                                                                                 | SECTION 14A SAY-ON-PAY VOTES |        5555555 |                0 | FOR         |                                  5555555 | FOR                         |  |
| INVENTIVA SA                         |  | 05/22/2025     | SETTING OF THE TOTAL REMUNERATION AMOUNT ALLOCATED TO MEMBERS OF THE BOARD OF DIRECTORS                                                                                                                                                                                                                                     | SECTION 14A SAY-ON-PAY VOTES |        5555555 |                0 | FOR         |                                  5555555 | FOR                         |  |
| INVENTIVA SA                         |  | 05/22/2025     | APPROVAL OF THE REMUNERATION POLICY FOR THE COMPANY'S DIRECTORS                                                                                                                                                                                                                                                             | SECTION 14A SAY-ON-PAY VOTES |        5555555 |                0 | FOR         |                                  5555555 | FOR                         |  |
| IOVANCE BIOTHERAPEUTICS, INC.        | 462260100 | 06/10/2025     | TO APPROVE, BY NON-BINDING ADVISORY VOTE, THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                                 | SECTION 14A SAY-ON-PAY VOTES |          67920 |                0 | FOR         |                                    67920 | FOR                         |  |
| JANUX THERAPEUTICS, INC.             | 47103J105 | 06/11/2025     | APPROVAL, ON AN ADVISORY BASIS, OF THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS ("SAY-ON-PAY"), AS DISCLOSED IN THE ACCOMPANYING PROXY STATEMENT.                                                                                                                                                                       | SECTION 14A SAY-ON-PAY VOTES |          32712 |                0 | FOR         |                                    32712 | FOR                         |  |
| JANUX THERAPEUTICS, INC.             | 47103J105 | 06/11/2025     | INDICATION, ON AN ADVISORY BASIS, OF THE PREFERRED FREQUENCY OF HOLDING FUTURE SAY-ON-PAY VOTES ON THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS.                                                                                                                                                                        | SECTION 14A SAY-ON-PAY VOTES |          32712 |                0 | FOR         |                                    32712 | FOR                         |  |
| KALVISTA PHARMACEUTICALS, INC.       | 483497103 | 10/03/2024     | APPROVAL, ON A NON-BINDING ADVISORY BASIS, OF THE COMPENSATION PAID BY US TO OUR NAMED EXECUTIVE OFFICERS AS DISCLOSED IN THE PROXY STATEMENT.                                                                                                                                                                              | SECTION 14A SAY-ON-PAY VOTES |         500000 |                0 | FOR         |                                   500000 | FOR                         |  |
| MADRIGAL PHARMACEUTICALS INC.        | 558868105 | 06/20/2025     | ADVISORY VOTE TO APPROVE EXECUTIVE COMPENSATION                                                                                                                                                                                                                                                                             | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 | ABSTAIN     |                                        0 | FOR                         |  |
| MADRIGAL PHARMACEUTICALS INC.        | 558868105 | 06/20/2025     | ADVISORY VOTE TO APPROVE THE FREQUENCY OF FUTURE ADVISORY VOTES TO APPROVE EXECUTIVE COMPENSATION                                                                                                                                                                                                                           | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 | ABSTAIN     |                                        0 | FOR                         |  |
| MEDTRONIC PLC                        | G5960L103 | 10/17/2024     | APPROVING, ON AN ADVISORY BASIS, THE COMPANY'S EXECUTIVE COMPENSATION.                                                                                                                                                                                                                                                      | SECTION 14A SAY-ON-PAY VOTES |           1617 |                0 | FOR         |                                     1617 | FOR                         |  |
| MEREO BIOPHARMA GROUP PLC            | 589492107 | 05/13/2025     | THAT THE COMPENSATION OF THE COMPANY'S NAMED EXECUTIVE OFFICERS BE APPROVED, ON AN ADVISORY (NON-BINDING) BASIS.                                                                                                                                                                                                            | SECTION 14A SAY-ON-PAY VOTES |         214905 |                0 | FOR         |                                   214905 | FOR                         |  |
| MEREO BIOPHARMA GROUP PLC            | 589492107 | 05/13/2025     | THAT THE FREQUENCY OF FUTURE ADVISORY VOTES ON THE COMPENSATION OF THE COMPANY'S NAMED EXECUTIVE OFFICERS BE APPROVED, ON AN ADVISORY (NONBINDING) BASIS.                                                                                                                                                                   | SECTION 14A SAY-ON-PAY VOTES |         214905 |                0 | FOR         |                                   214905 | FOR                         |  |
| MERUS N.V.                           | N5749R100 | 05/21/2025     | APPROVAL, ON AN ADVISORY (NON-BINDING) BASIS, OF THE COMPENSATION OF MERUS N.V.'S NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                 | SECTION 14A SAY-ON-PAY VOTES |         247974 |                0 | FOR         |                                   247974 | FOR                         |  |
| NURIX THERAPEUTICS, INC.             | 67080M103 | 05/19/2025     | TO APPROVE, ON A NON-BINDING ADVISORY BASIS, THE COMPENSATION OF THE COMPANY'S NAMED EXECUTIVE OFFICERS AS DISCLOSED IN THE PROXY STATEMENT.                                                                                                                                                                                | SECTION 14A SAY-ON-PAY VOTES |           6704 |                0 | FOR         |                                     6704 | FOR                         |  |
| NUVALENT, INC.                       | 670703107 | 06/18/2025     | TO APPROVE, ON AN ADVISORY BASIS, THE COMPENSATION PAID TO OUR NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                                    | SECTION 14A SAY-ON-PAY VOTES |        1187628 |                0 | FOR         |                                  1187628 | FOR                         |  |
| OCULAR THERAPEUTIX, INC.             | 67576A100 | 06/11/2025     | TO APPROVE AN ADVISORY VOTE ON NAMED EXECUTIVE OFFICER COMPENSATION.                                                                                                                                                                                                                                                        | SECTION 14A SAY-ON-PAY VOTES |            532 |                0 | FOR         |                                      532 | FOR                         |  |
| OPUS GENETICS, INC.                  | 67577R102 | 04/30/2025     | APPROVE, ON AN ADVISORY BASIS, THE COMPENSATION OF THE COMPANY'S NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                                  | SECTION 14A SAY-ON-PAY VOTES |        4324069 |                0 | FOR         |                                  4324069 | FOR                         |  |
| OUTSET MEDICAL, INC.                 | 690145206 | 06/02/2025     | TO APPROVE, ON A NON-BINDING BASIS, THE 2024 COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS                                                                                                                                                                                                                                   | SECTION 14A SAY-ON-PAY VOTES |         833333 |                0 | FOR         |                                   833333 | FOR                         |  |
| PRAXIS PRECISION MEDICINES, INC.     | 74006W207 | 06/26/2025     | TO APPROVE, ON AN ADVISORY (NON-BINDING) BASIS, THE COMPENSATION OF THE NAMED EXECUTIVE OFFICERS AS DISCLOSED IN THE COMPANY'S PROXY STATEMENT FOR THE 2025 ANNUAL MEETING OF STOCKHOLDERS PURSUANT TO THE APPLICABLE COMPENSATION DISCLOSURE RULES OF THE SEC, INCLUDING THE COMPENSATION TABLES AND NARRATIVE DISCUSSION. | SECTION 14A SAY-ON-PAY VOTES |        1093950 |                0 | FOR         |                                  1093950 | FOR                         |  |
| PROTAGONIST THERAPEUTICS, INC.       | 74366E102 | 06/20/2025     | TO APPROVE, ON A NON-BINDING, ADVISORY BASIS, THE COMPENSATION OF THE COMPANY'S NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                   | SECTION 14A SAY-ON-PAY VOTES |         547562 |                0 | FOR         |                                   547562 | FOR                         |  |
| RAPT THERAPEUTICS, INC.              | 75382E109 | 05/29/2025     | TO APPROVE, ON AN ADVISORY BASIS, THE COMPENSATION OF RAPT THERAPEUTICS, INC.'S NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                   | SECTION 14A SAY-ON-PAY VOTES |        3352807 |                0 | FOR         |                                  3352807 | FOR                         |  |
| RAPT THERAPEUTICS, INC.              | 75382E109 | 05/29/2025     | TO INDICATE, ON AN ADVISORY BASIS, THE PREFERRED FREQUENCY OF STOCKHOLDER ADVISORY VOTES ON THE COMPENSATION OF RAPT THERAPEUTICS, INC.'S NAMED EXECUTIVE OFFICERS.                                                                                                                                                         | SECTION 14A SAY-ON-PAY VOTES |        3352807 |                0 | FOR         |                                  3352807 | FOR                         |  |
| REPLIGEN CORPORATION                 | 759916109 | 05/15/2025     | ADVISORY VOTE TO APPROVE THE COMPENSATION PAID TO REPLIGEN CORPORATION'S NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                          | SECTION 14A SAY-ON-PAY VOTES |            469 |                0 | FOR         |                                      469 | FOR                         |  |
| RHYTHM PHARMACEUTICALS, INC.         | 76243J105 | 09/18/2024     | APPROVAL, ON AN ADVISORY (NON-BINDING) BASIS, OF THE COMPENSATION OF THE NAMED EXECUTIVE OFFICERS OF THE COMPANY.                                                                                                                                                                                                           | SECTION 14A SAY-ON-PAY VOTES |        2107681 |                0 | FOR         |                                  2107681 | FOR                         |  |
| RHYTHM PHARMACEUTICALS, INC.         | 76243J105 | 06/24/2025     | APPROVAL, ON AN ADVISORY (NON-BINDING) BASIS, OF THE COMPENSATION OF THE NAMED EXECUTIVE OFFICERS OF THE COMPANY.                                                                                                                                                                                                           | SECTION 14A SAY-ON-PAY VOTES |        1990967 |                0 | FOR         |                                  1990967 | FOR                         |  |
| SOLID BIOSCIENCES INC.               | 83422E204 | 06/12/2025     | THE APPROVAL OF AN ADVISORY VOTE ON EXECUTIVE COMPENSATION.                                                                                                                                                                                                                                                                 | SECTION 14A SAY-ON-PAY VOTES |       10795715 |                0 | FOR         |                                 10795715 | FOR                         |  |
| SPYRE THERAPEUTICS INC.              | 00773J202 | 05/29/2025     | TO APPROVE, ON A NON-BINDING, ADVISORY BASIS, THE COMPENSATION OF THE COMPANY'S NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                   | SECTION 14A SAY-ON-PAY VOTES |        1311814 |                0 | FOR         |                                  1311814 | FOR                         |  |
| TRAVERE THERAPEUTICS, INC.           | 89422G107 | 05/15/2025     | TO APPROVE, ON AN ADVISORY BASIS, THE COMPENSATION OF THE COMPANY'S NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                               | SECTION 14A SAY-ON-PAY VOTES |          90748 |                0 | FOR         |                                    90748 | FOR                         |  |
| VERONA PHARMA PLC                    | 925050106 | 04/24/2025     | TO APPROVE, ON AN ADVISORY (NON-BINDING) BASIS, THE COMPENSATION OF THE COMPANY'S NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                 | SECTION 14A SAY-ON-PAY VOTES |        4897113 |                0 | FOR         |                                  4897113 | FOR                         |  |
| VIKING THERAPEUTICS INC              | 92686J106 | 05/20/2025     | TO APPROVE, ON AN ADVISORY BASIS, THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                                         | SECTION 14A SAY-ON-PAY VOTES |              0 |                0 | ABSTAIN     |                                        0 | FOR                         |  |
| VIRIDIAN THERAPEUTICS, INC.          | 92790C104 | 06/20/2025     | TO APPROVE, ON AN ADVISORY BASIS, THE COMPENSATION OF THE COMPANY'S NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                               | SECTION 14A SAY-ON-PAY VOTES |          90506 |                0 | FOR         |                                    90506 | FOR                         |  |
| ZYMEWORKS INC.                       | 98985Y108 | 12/10/2024     | ADVISORY VOTE ON THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS.                                                                                                                                                                                                                                                          | SECTION 14A SAY-ON-PAY VOTES |         858438 |                0 | FOR         |                                   858438 | FOR                         |  |

## N-PX: Signature Block

**Reporting Person:** PERCEPTIVE ADVISORS LLC

**By (Signature):** Alexander Rakitin

**By (Printed Signature):** Alexander Rakitin

**By (Title):** Chief Compliance Officer

**Date:** 08/21/2025