# EDGAR Filing Document

**Accession Number:** 0001055951
**File Stem:** 0001172661-23-001310
**Filing Date:** 2023-2
**Character Count:** 16138
**Document Hash:** a0833815e4432e51af604d34c6c5abb2
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001172661-23-001310.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001172661-23-001310

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**EFFECTIVENESS DATE**: 20230214

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** ORBIMED ADVISORS LLC
- **CENTRAL INDEX KEY:** 0001055951
- **IRS NUMBER:** 133976876
- **STATE OF INCORPORATION:** DE

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-06774
- **FILM NUMBER:** 23629087

**BUSINESS ADDRESS:**
- **STREET 1:** 601 LEXINGTON AVENUE
- **STREET 2:** 54TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10022
- **BUSINESS PHONE:** (212) 739-6400

**MAIL ADDRESS:**
- **STREET 1:** 601 LEXINGTON AVENUE
- **STREET 2:** 54TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10022

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2022

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** ORBIMED ADVISORS LLC<br>**Address:** 601 Lexington Avenue<br>54th Floor<br>New York, NY 10022

**Form 13F File Number:** 028-06774

**CRD Number (if applicable):** 000118608

**SEC File Number (if applicable):** 801-61046

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Sven H. Borho<br>**Title:** Member<br>**Phone:** 212-739-6400

**Signature, Place, and Date of Signing:**

/s/ Sven H. Borho  New York, NY  02-14-2023<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 1

**Form 13F Information Table Entry Total:** 116

**Form 13F Information Table Value Total:** $5227458389

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

| No.   | Name                | Form 13F File Number   |
|:---|:---|:---|
|  | ORBIMED CAPITAL LLC | 028-10410              |

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| 2SEVENTY BIO INC | COMMON STOCK | 901384107 |  | 9756981 | 1041300 | SH |  | DFND |  | 337000 | 0 | 704300 |
| 89BIO INC | COM | 282559103 |  | 46577402 | 3658869 | SH |  | SOLE |  | 3658869 | 0 | 0 |
| ABCELLERA BIOLOGICS INC | COM | 00288U106 |  | 42351180 | 4180768 | SH |  | SOLE |  | 4180768 | 0 | 0 |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 |  | 43445336 | 2758434 | SH |  | DFND |  | 488400 | 0 | 2270034 |
| ACUTUS MED INC | COM | 005111109 |  | 3045644 | 2648386 | SH |  | SOLE |  | 2648386 | 0 | 0 |
| ADICET BIO INC | COM | 007002108 |  | 66577432 | 7447140 | SH |  | SOLE |  | 7447140 | 0 | 0 |
| AEGLEA BIOTHERAPEUTICS INC | COM | 00773J103 |  | 808570 | 1797221 | SH |  | SOLE |  | 1797221 | 0 | 0 |
| AEROVATE THERAPEUTICS INC | COM | 008064107 |  | 22254522 | 759540 | SH |  | DFND |  | 215800 | 0 | 543740 |
| ALPINE IMMUNE SCIENCES INC | COM | 02083G100 |  | 29999701 | 4081592 | SH |  | SOLE |  | 4081592 | 0 | 0 |
| ALX ONCOLOGY HLDGS INC | COM | 00166B105 |  | 32356170 | 2871000 | SH |  | DFND |  | 605000 | 0 | 2266000 |
| AMICUS THERAPEUTICS INC | COM | 03152W109 |  | 6300360 | 516000 | SH |  | DFND |  | 72700 | 0 | 443300 |
| AMNEAL PHARMACEUTICALS INC | COM STK CL A | 03168L105 |  | 3151145 | 1583490 | SH |  | DFND |  | 471800 | 0 | 1111690 |
| APPLIED THERAPEUTICS INC | COM | 03828A101 |  | 2318700 | 3050921 | SH |  | SOLE |  | 3050921 | 0 | 0 |
| ARCUTIS BIOTHERAPEUTICS INC | COM | 03969K108 |  | 36409598 | 2460108 | SH |  | SOLE |  | 2460108 | 0 | 0 |
| ARGENX SE | SPONSORED ADR | 04016X101 |  | 6137046 | 16200 | SH |  | DFND |  | 750 | 0 | 15450 |
| ARS PHARMACEUTICALS INC | COM | 82835W108 |  | 74559766 | 8740887 | SH |  | DFND |  | 7788510 | 0 | 952377 |
| BELLUS HEALTH INC NEW | COM NEW | 07987C204 |  | 38658842 | 4708900 | SH |  | DFND |  | 2213400 | 0 | 2495500 |
| BIOATLA INC | COM | 09077B104 |  | 2742069 | 332372 | SH |  | SOLE |  | 332372 | 0 | 0 |
| BIOGEN INC | COM | 09062X103 |  | 71500744 | 258200 | SH |  | DFND |  | 37000 | 0 | 221200 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 |  | 167158083 | 1615210 | SH |  | DFND |  | 147600 | 0 | 1467610 |
| BIOMX INC | COM | 09090D103 |  | 525278 | 2813489 | SH |  | SOLE |  | 2813489 | 0 | 0 |
| BIONTECH SE | SPONSORED ADS | 09075V102 |  | 5452986 | 36300 | SH |  | SOLE |  | 0 | 0 | 36300 |
| BOLT BIOTHERAPEUTICS INC | COM | 097702104 |  | 1002377 | 771059 | SH |  | SOLE |  | 771059 | 0 | 0 |
| BOSTON SCIENTIFIC CORP | COM | 101137107 |  | 180369714 | 3898200 | SH |  | SOLE |  | 0 | 0 | 3898200 |
| BRIDGEBIO PHARMA INC | NOTE 2.250% 2/0 | 10806XAD4 |  | 12600000 | 30000000 | PRN |  | SOLE |  | 30000000 | 0 | 0 |
| BRIDGEBIO PHARMA INC | NOTE 2.500% 3/1 | 10806XAB8 |  | 7950000 | 20000000 | PRN |  | SOLE |  | 20000000 | 0 | 0 |
| BRISTOL-MYERS SQUIBB CO | COM | 110122108 |  | 185983555 | 2584900 | SH |  | SOLE |  | 0 | 0 | 2584900 |
| CHEMOMAB THERAPEUTICS LTD | SPONSORED ADS | 16385C104 |  | 8250157 | 2578174 | SH |  | SOLE |  | 2578174 | 0 | 0 |
| CHINOOK THERAPEUTICS INC | COM | 16961L106 |  | 53167660 | 2029300 | SH |  | DFND |  | 478300 | 0 | 1551000 |
| CINCOR PHARMA INC | COM | 17240Y109 |  | 23424740 | 1906000 | SH |  | DFND |  | 514000 | 0 | 1392000 |
| COMPASS THERAPEUTICS INC | COM | 20454B104 |  | 112485136 | 22362850 | SH |  | DFND |  | 18791422 | 0 | 3571428 |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 |  | 5902106 | 6943654 | SH |  | SOLE |  | 6943654 | 0 | 0 |
| CRINETICS PHARMACEUTICALS IN | COM | 22663K107 |  | 58502831 | 3196876 | SH |  | SOLE |  | 3196876 | 0 | 0 |
| CULLINAN ONCOLOGY INC | COM | 230031106 |  | 6723378 | 637287 | SH |  | SOLE |  | 637287 | 0 | 0 |
| CYBIN INC | COM | 23256X100 |  | 1651629 | 5386299 | SH |  | SOLE |  | 0 | 0 | 5386299 |
| DECIBEL THERAPEUTICS INC | COM | 24343R106 |  | 10137644 | 4945192 | SH |  | DFND |  | 4061774 | 0 | 883418 |
| DISC MEDICINE INC | COM | 254604101 |  | 42981116 | 2160941 | SH |  | SOLE |  | 2160941 | 0 | 0 |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 |  | 130230553 | 14567176 | SH |  | DFND |  | 14301551 | 0 | 265625 |
| EDWARDS LIFESCIENCES CORP | COM | 28176E108 |  | 64201905 | 860500 | SH |  | SOLE |  | 0 | 0 | 860500 |
| ESSA PHARMA INC | COM NEW | 29668H708 |  | 920556 | 365300 | SH |  | SOLE |  | 365300 | 0 | 0 |
| EVOLENT HEALTH INC | CL A | 30050B101 |  | 79321283 | 2824832 | SH |  | DFND |  | 143900 | 0 | 2680932 |
| EYEPOINT PHARMACEUTICALS INC | COM NEW | 30233G209 |  | 1706747 | 487642 | SH |  | DFND |  | 117200 | 0 | 370442 |
| FUSION PHARMACEUTICALS INC | COM | 36118A100 |  | 10158026 | 3224770 | SH |  | DFND |  | 2930670 | 0 | 294100 |
| GALECTO INC | COM | 36322Q107 |  | 4704578 | 4090937 | SH |  | DFND |  | 3803255 | 0 | 287682 |
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 |  | 15766423 | 1622060 | SH |  | DFND |  | 239100 | 0 | 1382960 |
| GOODRX HLDGS INC | COM CL A | 38246G108 |  | 1806062 | 387567 | SH |  | DFND |  | 125600 | 0 | 261967 |
| GRACELL BIOTECHNOLOGIES INC | SPONSORED ADS | 38406L103 |  | 18135201 | 7884870 | SH |  | DFND |  | 5970672 | 0 | 1914198 |
| GRAYBUG VISION INC | COMMON | 38942Q103 |  | 2081674 | 4163347 | SH |  | SOLE |  | 4163347 | 0 | 0 |
| HARPOON THERAPEUTICS INC | COM | 41358P106 |  | 1100521 | 1516496 | SH |  | DFND |  | 804206 | 0 | 712290 |
| HORIZON THERAPEUTICS PUB L | SHS | G46188101 |  | 19459800 | 171000 | SH |  | DFND |  | 33100 | 0 | 137900 |
| HUMANA INC | COM | 444859102 |  | 178600653 | 348700 | SH |  | SOLE |  | 0 | 0 | 348700 |
| IKENA ONCOLOGY INC | NONVOTING | 000000000 |  | 17204058 | 6467691 | SH |  | DFND |  | 5838536 | 0 | 629155 |
| IKENA ONCOLOGY INC | COM | 45175G108 |  | 7804283 | 2933941 | SH |  | DFND |  | 1936886 | 0 | 997055 |
| IMARA INC | COM | 45249V107 |  | 17941063 | 4386568 | SH |  | DFND |  | 4199068 | 0 | 187500 |
| INTUITIVE SURGICAL INC | COM NEW | 46120E602 |  | 164649675 | 620500 | SH |  | SOLE |  | 0 | 0 | 620500 |
| INVIVYD INC | COM | 00534A102 |  | 7905600 | 5270400 | SH |  | SOLE |  | 5270400 | 0 | 0 |
| IONIS PHARMACEUTICALS INC | COM | 462222100 |  | 75298272 | 1993600 | SH |  | DFND |  | 136300 | 0 | 1857300 |
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 |  | 12827657 | 2007458 | SH |  | SOLE |  | 0 | 0 | 2007458 |
| JANUX THERAPEUTICS INC | COM | 47103J105 |  | 37355204 | 2836386 | SH |  | DFND |  | 2489664 | 0 | 346722 |
| KEROS THERAPEUTICS INC | COM | 492327101 |  | 80645604 | 1679417 | SH |  | DFND |  | 1268734 | 0 | 410683 |
| KEZAR LIFE SCIENCES INC | COM | 49372L100 |  | 32273627 | 4584322 | SH |  | DFND |  | 1089200 | 0 | 3495122 |
| KINNATE BIOPHARMA INC | COM | 49705R105 |  | 24666137 | 4043629 | SH |  | DFND |  | 3593629 | 0 | 450000 |
| MEREO BIOPHARMA GROUP PLC | SPON ADS | 589492107 |  | 7954142 | 10605522 | SH |  | DFND |  | 5777210 | 0 | 4828312 |
| MERRIMACK PHARMACEUTICALS IN | COM NEW | 590328209 |  | 843456 | 73600 | SH |  | DFND |  | 24900 | 0 | 48700 |
| MERSANA THERAPEUTICS INC | COM | 59045L106 |  | 52807021 | 9011437 | SH |  | DFND |  | 1928600 | 0 | 7082837 |
| MIRATI THERAPEUTICS INC | COM | 60468T105 |  | 58164085 | 1283692 | SH |  | DFND |  | 122800 | 0 | 1160892 |
| MODERNA INC | COM | 60770K107 |  | 14827631 | 82550 | SH |  | SOLE |  | 0 | 0 | 82550 |
| MONTE ROSA THERAPEUTICS INC | COM | 61225M102 |  | 208278 | 27369 | SH |  | SOLE |  | 0 | 0 | 27369 |
| NATERA INC | COM | 632307104 |  | 78185000 | 1946353 | SH |  | DFND |  | 159550 | 0 | 1786803 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 |  | 82138888 | 687700 | SH |  | SOLE |  | 0 | 0 | 687700 |
| NEUROPACE INC | COM | 641288105 |  | 5978299 | 4012281 | SH |  | SOLE |  | 4012281 | 0 | 0 |
| NEXTCURE INC | COM | 65343E108 |  | 3822528 | 2711013 | SH |  | SOLE |  | 2711013 | 0 | 0 |
| ORIC PHARMACEUTICALS INC | COM | 68622P109 |  | 9468576 | 1607568 | SH |  | SOLE |  | 1607568 | 0 | 0 |
| PASSAGE BIO INC | COM | 702712100 |  | 12326159 | 8931999 | SH |  | DFND |  | 6841423 | 0 | 2090576 |
| PFIZER INC | COM | 717081103 |  | 71408064 | 1393600 | SH |  | SOLE |  | 0 | 0 | 1393600 |
| PMV PHARMACEUTICALS INC | COM | 69353Y103 |  | 57098770 | 6563077 | SH |  | SOLE |  | 6563077 | 0 | 0 |
| PRELUDE THERAPEUTICS INC | COM | 74065P101 |  | 60639734 | 10039691 | SH |  | DFND |  | 9250191 | 0 | 789500 |
| PRELUDE THERAPEUTICS INC | NONVOTING | 000000000 |  | 34308323 | 5680186 | SH |  | DFND |  | 5596886 | 0 | 83300 |
| PROGYNY INC | COM | 74340E103 |  | 32240250 | 1035000 | SH |  | SOLE |  | 0 | 0 | 1035000 |
| PROTARA THERAPEUTICS INC | COM STK | 74365U107 |  | 2226118 | 830641 | SH |  | DFND |  | 158900 | 0 | 671741 |
| PYXIS ONCOLOGY INC | COMMON STOCK | 747324101 |  | 1136658 | 848252 | SH |  | SOLE |  | 0 | 0 | 848252 |
| RAPT THERAPEUTICS INC | COM | 75382E109 |  | 24771186 | 1251070 | SH |  | DFND |  | 310400 | 0 | 940670 |
| REPARE THERAPEUTICS INC | COM | 760273102 |  | 48873798 | 3322488 | SH |  | DFND |  | 3177041 | 0 | 145447 |
| RXSIGHT INC | COM | 78349D107 |  | 15239894 | 1202833 | SH |  | DFND |  | 279100 | 0 | 923733 |
| SANOFI | SPONSORED ADR | 80105N105 |  | 4843000 | 100000 | SH | Call | DFND |  | 33000 | 0 | 67000 |
| SAREPTA THERAPEUTICS INC | COM | 803607100 |  | 125990634 | 972300 | SH |  | DFND |  | 56900 | 0 | 915400 |
| SCHOLAR ROCK HLDG CORP | COM | 80706P103 |  | 7954977 | 879003 | SH |  | DFND |  | 378921 | 0 | 500082 |
| SCPHARMACEUTICALS INC | COM | 810648105 |  | 39861816 | 5559528 | SH |  | SOLE |  | 5559528 | 0 | 0 |
| SEAGEN INC | COM | 81181C104 |  | 117433980 | 913812 | SH |  | DFND |  | 59800 | 0 | 854012 |
| SI-BONE INC | COM | 825704109 |  | 45804800 | 3368000 | SH |  | DFND |  | 166900 | 0 | 3201100 |
| SINGULAR GENOMICS SYSTEMS IN | COM | 82933R100 |  | 1086801 | 540697 | SH |  | SOLE |  | 540697 | 0 | 0 |
| SINOVAC BIOTECH LTD | COM | P8696W104 |  | 340000000 | 2718735 | SH |  | SOLE |  | 0 | 0 | 2718735 |
| SPDR SER TR | S BIOTECH | 78464A870 |  | 6341200 | 76400 | SH |  | DFND |  | 24000 | 0 | 52400 |
| SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 |  | 136552500 | 5250000 | SH |  | SOLE |  | 5250000 | 0 | 0 |
| STRYKER CORPORATION | COM | 863667101 |  | 117599690 | 481000 | SH |  | SOLE |  | 0 | 0 | 481000 |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 |  | 51065425 | 2006500 | SH |  | DFND |  | 444000 | 0 | 1562500 |
| SYNLOGIC INC | COM | 87166L100 |  | 4582796 | 6029995 | SH |  | SOLE |  | 6029995 | 0 | 0 |
| TELA BIO INC | COM | 872381108 |  | 34816733 | 3027542 | SH |  | SOLE |  | 3027542 | 0 | 0 |
| TENET HEALTHCARE CORP | COM NEW | 88033G407 |  | 59538437 | 1220300 | SH |  | SOLE |  | 0 | 0 | 1220300 |
| TERNS PHARMACEUTICALS INC | COM | 880881107 |  | 77562794 | 7619135 | SH |  | SOLE |  | 7619135 | 0 | 0 |
| THERMO FISHER SCIENTIFIC INC | COM | 883556102 |  | 111349518 | 202200 | SH |  | SOLE |  | 0 | 0 | 202200 |
| THESEUS PHARMACEUTICALS INC | COM | 88369M101 |  | 85823667 | 17233668 | SH |  | SOLE |  | 17233668 | 0 | 0 |
| THIRD HARMONIC BIO INC | COM | 88427A107 |  | 24850005 | 5779071 | SH |  | SOLE |  | 5779071 | 0 | 0 |
| TRAVERE THERAPEUTICS INC | COM | 89422G107 |  | 26353324 | 1253130 | SH |  | DFND |  | 267700 | 0 | 985430 |
| UNIQURE NV | SHS | N90064101 |  | 39617072 | 1747555 | SH |  | SOLE |  | 0 | 0 | 1747555 |
| UNITEDHEALTH GROUP INC | COM | 91324P102 |  | 201733490 | 380500 | SH |  | SOLE |  | 0 | 0 | 380500 |
| VAXCYTE INC | COM | 92243G108 |  | 61525892 | 1283126 | SH |  | DFND |  | 157800 | 0 | 1125326 |
| VECTIVBIO HLDG AG | ORD SHS | H9060V101 |  | 60714451 | 7006861 | SH |  | DFND |  | 6713561 | 0 | 293300 |
| VENTYX BIOSCIENCES INC | COM | 92332V107 |  | 30330750 | 925000 | SH |  | DFND |  | 297888 | 0 | 627112 |
| VERASTEM INC | COM | 92337C104 |  | 6642553 | 16503237 | SH |  | SOLE |  | 16503237 | 0 | 0 |
| VERONA PHARMA PLC | SPONSORED ADS | 925050106 |  | 119473912 | 4572289 | SH |  | DFND |  | 4260691 | 0 | 311598 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 |  | 78403770 | 271500 | SH |  | SOLE |  | 0 | 0 | 271500 |
| VIGIL NEUROSCIENCE INC | COM | 92673K108 |  | 5611138 | 448891 | SH |  | SOLE |  | 448891 | 0 | 0 |
| X4 PHARMACEUTICALS INC | COM | 98420X103 |  | 5777002 | 5817726 | SH |  | SOLE |  | 5817726 | 0 | 0 |
| XENON PHARMACEUTICALS INC | COM | 98420N105 |  | 45309013 | 1149100 | SH |  | DFND |  | 230000 | 0 | 919100 |
| XTANT MED HLDGS INC | COM NEW | 98420P308 |  | 48255631 | 73114592 | SH |  | SOLE |  | 73114592 | 0 | 0 |

---