# EDGAR Filing Document

**Accession Number:** 0001346824
**File Stem:** 0001104659-26-062637
**Filing Date:** 2026-5
**Character Count:** 14535
**Document Hash:** fa83fe58b08233393760ba236dee0fd1
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-26-062637.hdr.sgml**: 20260515

**ACCESSION NUMBER**: 0001104659-26-062637

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20260331

**FILED AS OF DATE**: 20260515

**DATE AS OF CHANGE**: 20260515

**EFFECTIVENESS DATE**: 20260515

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** RA CAPITAL MANAGEMENT, L.P.
- **CENTRAL INDEX KEY:** 0001346824

**ORGANIZATION NAME:**
- **EIN:** 830406777
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-12884
- **FILM NUMBER:** 26988491

**BUSINESS ADDRESS:**
- **STREET 1:** 200 BERKELEY STREET, 18TH FLOOR
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02116
- **BUSINESS PHONE:** 617-778-2500

**MAIL ADDRESS:**
- **STREET 1:** 200 BERKELEY STREET, 18TH FLOOR
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02116

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** RA CAPITAL MANAGEMENT, LLC
- **DATE OF NAME CHANGE:** 20051213

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 03-31-2026

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** RA CAPITAL MANAGEMENT L.P.<br>**Address:** 200 BERKELEY STREET 18TH FLOOR<br>BOSTON, MA 02116

**Form 13F File Number:** 028-12884

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Rajeev Shah<br>**Title:** Authorized Signatory<br>**Phone:** 617-778-2500

**Signature, Place, and Date of Signing:**

/s/ Rajeev Shah  Boston, MA  05-15-2026<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 86

**Form 13F Information Table Value Total:** $9437744027

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| ACRIVON THERAPEUTICS INC | COMMON STOCK | 004890109 | BBG011RWR2Q4 | 11593306 | 8340508 | SH |  | SOLE |  | 8340508 | 0 | 0 |
| ADICET BIO INC | COMMON STOCK | 007002207 | BBG00JCXSJP3 | 8053669 | 1182624 | SH |  | SOLE |  | 1182624 | 0 | 0 |
| JADE BIOSCIENCES INC | COMMON STOCK | 008064206 | BBG00WGHZFH4 | 51578716 | 3671083 | SH |  | SOLE |  | 3671083 | 0 | 0 |
| ASSEMBLY BIOSCIENCES INC | COMMON STOCK | 045396207 | BBG000R62Q06 | 28316378 | 1020410 | SH |  | SOLE |  | 1020410 | 0 | 0 |
| BICARA THERAPEUTICS INC | COMMON STOCK | 055477103 | BBG00Z15DGK7 | 144321701 | 7255993 | SH |  | SOLE |  | 7255993 | 0 | 0 |
| CORVUS PHARMACEUTICALS INC | COMMON STOCK | 221015100 | BBG009F0TGH8 | 6583500 | 450000 | SH |  | SOLE |  | 450000 | 0 | 0 |
| DIANTHUS THERAPEUTICS INC | COMMON STOCK | 252828108 | BBG00FB2NPZ0 | 219176633 | 2611733 | SH |  | SOLE |  | 2611733 | 0 | 0 |
| DISC MEDICINE INC | COMMON STOCK | 254604101 | BBG00W9MJK79 | 156667131 | 2450221 | SH |  | SOLE |  | 2450221 | 0 | 0 |
| FULCRUM THERAPEUTICS INC | COMMON STOCK | 359616109 | BBG00DDY1RK9 | 46433873 | 6053960 | SH |  | SOLE |  | 6053960 | 0 | 0 |
| GERON CORP | COMMON STOCK | 374163103 | BBG000GX1891 | 95019335 | 63771366 | SH |  | SOLE |  | 63771366 | 0 | 0 |
| GRAIL INC | COMMON STOCK | 384747101 | BBG01N6CGW43 | 22132787 | 428266 | SH |  | SOLE |  | 428266 | 0 | 0 |
| HINGE HEALTH INC-A | COMMON STOCK | 433313103 | BBG00H8V6LH4 | 14059477 | 364613 | SH |  | SOLE |  | 364613 | 0 | 0 |
| INSPIRE MEDICAL SYSTEMS INC | COMMON STOCK | 457730109 | BBG00209SZJ7 | 16797698 | 325663 | SH |  | SOLE |  | 325663 | 0 | 0 |
| MACROGENICS INC | COMMON STOCK | 556099109 | BBG000BM2SF8 | 5387469 | 1864176 | SH |  | SOLE |  | 1864176 | 0 | 0 |
| MINERALYS THERAPEUTICS INC | COMMON STOCK | 603170101 | BBG00ZXN1GN3 | 208396598 | 7692750 | SH |  | SOLE |  | 7692750 | 0 | 0 |
| MIRUM PHARMACEUTICALS INC | COMMON STOCK | 604749101 | BBG00MH7T2M7 | 29428019 | 318554 | SH |  | SOLE |  | 318554 | 0 | 0 |
| NUVALENT INC-A | COMMON STOCK | 670703107 | BBG00Z1SLMK5 | 259623155 | 2534145 | SH |  | SOLE |  | 2534145 | 0 | 0 |
| OVID THERAPEUTICS INC | COMMON STOCK | 690469101 | BBG009F0TD76 | 23785080 | 10714000 | SH |  | SOLE |  | 10714000 | 0 | 0 |
| PALATIN TECHNOLOGIES INC | COMMON STOCK | 696077601 | BBG000BN9PY4 | 1219400 | 70000 | SH |  | SOLE |  | 70000 | 0 | 0 |
| PALISADE BIO INC | COMMON STOCK | 696389402 | BBG000QG4DJ2 | 12467203 | 7124116 | SH |  | SOLE |  | 7124116 | 0 | 0 |
| PEPGEN INC | COMMON STOCK | 713317105 | BBG012232618 | 35514245 | 20064545 | SH |  | SOLE |  | 20064545 | 0 | 0 |
| RANI THERAPEUTICS HOLDINGS-A | COMMON STOCK | 753018100 | BBG011R6PZ44 | 6245800 | 8500000 | SH |  | SOLE |  | 8500000 | 0 | 0 |
| SAREPTA THERAPEUTICS INC | COMMON STOCK | 803607100 | BBG000BCJ161 | 84920489 | 3902596 | SH |  | SOLE |  | 3902596 | 0 | 0 |
| SIONNA THERAPEUTICS INC | COMMON STOCK | 829401108 | BBG016X2DC85 | 397093254 | 9905045 | SH |  | SOLE |  | 9905045 | 0 | 0 |
| SUTRO BIOPHARMA INC | COMMON STOCK | 869367201 | BBG000R4V3P3 | 17818297 | 715307 | SH |  | SOLE |  | 715307 | 0 | 0 |
| TAYSHA GENE THERAPIES INC | COMMON STOCK | 877619106 | BBG00TJXFDP1 | 105293747 | 23555648 | SH |  | SOLE |  | 23555648 | 0 | 0 |
| VOR BIOPHARMA INC | COMMON STOCK | 929033207 | BBG00NBJRDT6 | 96425164 | 5404998 | SH |  | SOLE |  | 5404998 | 0 | 0 |
| WAYSTAR HOLDING CORP | COMMON STOCK | 946784105 | BBG01JRQSDB9 | 12763834 | 529400 | SH |  | SOLE |  | 529400 | 0 | 0 |
| 4D MOLECULAR THERAPEUTICS IN | COMMON STOCK | 35104E100 | BBG00QG40R88 | 47013442 | 5049779 | SH |  | SOLE |  | 5049779 | 0 | 0 |
| SOLID BIOSCIENCES INC | COMMON STOCK | 83422E204 | BBG00JN4FXG8 | 67247842 | 9339978 | SH |  | SOLE |  | 9339978 | 0 | 0 |
| ALX ONCOLOGY HOLDINGS INC | COMMON STOCK | 00166B105 | BBG00VR8SDG8 | 26088757 | 13011849 | SH |  | SOLE |  | 13011849 | 0 | 0 |
| ACLARIS THERAPEUTICS INC | COMMON STOCK | 00461U105 | BBG003LF0QR9 | 25515270 | 6804072 | SH |  | SOLE |  | 6804072 | 0 | 0 |
| ACUMEN PHARMACEUTICALS INC | COMMON STOCK | 00509G209 | BBG0058YJ317 | 49542699 | 20992669 | SH |  | SOLE |  | 20992669 | 0 | 0 |
| SPYRE THERAPEUTICS INC | COMMON STOCK | 00773J202 | BBG0067L94B2 | 81794513 | 1621620 | SH |  | SOLE |  | 1621620 | 0 | 0 |
| AKTIS ONCOLOGY INC | COMMON STOCK | 01021M104 | BBG00ZQS8KZ1 | 26890173 | 1503084 | SH |  | SOLE |  | 1503084 | 0 | 0 |
| ANTERIS TECHNOLOGIES GLOBAL | COMMON STOCK | 03675P102 | BBG01PLXJNR7 | 16650000 | 3000000 | SH |  | SOLE |  | 3000000 | 0 | 0 |
| ARTIVA BIOTHERAPEUTICS INC | COMMON STOCK | 04317A107 | BBG00VPZJ0F9 | 63455265 | 9853302 | SH |  | SOLE |  | 9853302 | 0 | 0 |
| ASCENDIS PHARMA A/S - ADR | SPONSORED ADR | 04351P101 | BBG007R7VNC1 | 2351686580 | 10281496 | SH |  | SOLE |  | 10281496 | 0 | 0 |
| ATRIUM THERAPEUTICS INC | COMMON STOCK | 04965N104 | BBG01Z0T3959 | 11553044 | 864102 | SH |  | SOLE |  | 864102 | 0 | 0 |
| AVALO THERAPEUTICS INC | COMMON STOCK | 05338F306 | BBG001QHW0Y8 | 9898112 | 662968 | SH |  | SOLE |  | 662968 | 0 | 0 |
| BENITEC BIOPHARMA INC | COMMON STOCK | 08205P209 | BBG00R712L56 | 19702500 | 1850000 | SH |  | SOLE |  | 1850000 | 0 | 0 |
| BIOCRYST PHARMACEUTICALS INC | COMMON STOCK | 09058V103 | BBG000BLYWX6 | 150674811 | 15827186 | SH |  | SOLE |  | 15827186 | 0 | 0 |
| BIOAGE LABS INC | COMMON STOCK | 09077V100 | BBG00HBTB0M9 | 28869834 | 1650648 | SH |  | SOLE |  | 1650648 | 0 | 0 |
| BRIGHT MINDS BIOSCIENCES INC | COMMON STOCK | 10919W405 | BBG00ZKX9FP7 | 19337050 | 265000 | SH |  | SOLE |  | 265000 | 0 | 0 |
| C4 THERAPEUTICS INC | COMMON STOCK | 12529R107 | BBG00BV2Y9B7 | 21040000 | 8000000 | SH |  | SOLE |  | 8000000 | 0 | 0 |
| CAPRICOR THERAPEUTICS INC | COMMON STOCK | 14070B309 | BBG000DZMK99 | 45838458 | 1507844 | SH |  | SOLE |  | 1507844 | 0 | 0 |
| CENTURY THERAPEUTICS INC | COMMON STOCK | 15673T100 | BBG00PM8N5W0 | 40125012 | 17754430 | SH |  | SOLE |  | 17754430 | 0 | 0 |
| CONTINEUM THERAPEUTICS INC-A | COMMON STOCK | 21217B100 | BBG01M27SVP6 | 16925917 | 1296012 | SH |  | SOLE |  | 1296012 | 0 | 0 |
| DESIGN THERAPEUTICS INC | COMMON STOCK | 25056L103 | BBG00SNC49V8 | 31632433 | 2972973 | SH |  | SOLE |  | 2972973 | 0 | 0 |
| EDGEWISE THERAPEUTICS INC | COMMON STOCK | 28036F105 | BBG00K4Y2H24 | 328495766 | 10428437 | SH |  | SOLE |  | 10428437 | 0 | 0 |
| CLIMB BIO INC | COMMON STOCK | 28658R106 | BBG00ZNKL0K6 | 60424309 | 8821067 | SH |  | SOLE |  | 8821067 | 0 | 0 |
| CLIMB BIO INC | COMMON STOCK | 28658R106 | BBG00ZNKL0K6 | 16987123 | 2479872 | SH |  | OTR |  | 2479872 | 0 | 0 |
| EQUILLIUM INC | COMMON STOCK | 29446K106 | BBG00LSL8C10 | 6192672 | 3096336 | SH |  | SOLE |  | 3096336 | 0 | 0 |
| EVOMMUNE INC | COMMON STOCK | 30054Y107 | BBG00Y79N887 | 80341728 | 3494638 | SH |  | SOLE |  | 3494638 | 0 | 0 |
| DAMORA THERAPEUTICS INC | COMMON STOCK | 36322Q206 | BBG00XMLGWC5 | 62142129 | 2399310 | SH |  | SOLE |  | 2399310 | 0 | 0 |
| JANUX THERAPEUTICS INC | COMMON STOCK | 47103J105 | BBG00ZHSKH11 | 155536733 | 11189693 | SH |  | SOLE |  | 11189693 | 0 | 0 |
| KARYOPHARM THERAPEUTICS INC | COMMON STOCK | 48576U205 | BBG001J272L7 | 10679662 | 1917354 | SH |  | SOLE |  | 1917354 | 0 | 0 |
| LB PHARMACEUTICALS INC | COMMON STOCK | 50180M108 | BBG00XNP5MQ4 | 54464175 | 2208604 | SH |  | SOLE |  | 2208604 | 0 | 0 |
| LENZ THERAPEUTICS INC | COMMON STOCK | 52635N103 | BBG00XDH4NZ2 | 38236230 | 4178823 | SH |  | SOLE |  | 4178823 | 0 | 0 |
| LEXEO THERAPEUTICS INC | COMMON STOCK | 52886X107 | BBG00YB1C8M5 | 28700000 | 5000000 | SH |  | SOLE |  | 5000000 | 0 | 0 |
| MAPLIGHT THERAPEUTICS INC | COMMON STOCK | 56565P103 | BBG01JZ5DBQ0 | 5047817 | 248294 | SH |  | SOLE |  | 248294 | 0 | 0 |
| MONOPAR THERAPEUTICS INC | COMMON STOCK | 61023L207 | BBG00J7K8D90 | 36556272 | 667207 | SH |  | SOLE |  | 667207 | 0 | 0 |
| NKARTA INC | COMMON STOCK | 65487U108 | BBG00JXHS9G7 | 22798822 | 10805129 | SH |  | SOLE |  | 10805129 | 0 | 0 |
| OLEMA PHARMACEUTICALS INC | COMMON STOCK | 68062P106 | BBG00T5JMRT4 | 38766000 | 2600000 | SH |  | SOLE |  | 2600000 | 0 | 0 |
| ONKURE THERAPEUTICS INC-A | COMMON STOCK | 68277Q105 | BBG00JVRSRC1 | 16553099 | 3998333 | SH |  | SOLE |  | 3998333 | 0 | 0 |
| PRAXIS PRECISION MEDICINES I | COMMON STOCK | 74006W207 | BBG00W9LF2G5 | 120430434 | 373787 | SH |  | SOLE |  | 373787 | 0 | 0 |
| RELMADA THERAPEUTICS INC | COMMON STOCK | 75955J402 | BBG003MKSL16 | 20513688 | 2947369 | SH |  | SOLE |  | 2947369 | 0 | 0 |
| REZOLUTE INC | COMMON STOCK | 76200L309 | BBG001XWWHL4 | 27999000 | 9180000 | SH |  | SOLE |  | 9180000 | 0 | 0 |
| RHYTHM PHARMACEUTICALS INC | COMMON STOCK | 76243J105 | BBG007DLZ601 | 579814814 | 6666837 | SH |  | SOLE |  | 6666837 | 0 | 0 |
| SAB BIOTHERAPEUTICS INC | COMMON STOCK | 78397T202 | BBG00YHY0G24 | 16857745 | 4401500 | SH |  | SOLE |  | 4401500 | 0 | 0 |
| GENEDX HOLDINGS CORP | COMMON STOCK | 81663L200 | BBG00XDHY5P9 | 13478943 | 209887 | SH |  | SOLE |  | 209887 | 0 | 0 |
| SEPTERNA INC | COMMON STOCK | 81734D104 | BBG014WY1V28 | 168110468 | 6995858 | SH |  | SOLE |  | 6995858 | 0 | 0 |
| ARS PHARMACEUTICALS INC | COMMON STOCK | 82835W108 | BBG00FZQGXG3 | 87213645 | 10860977 | SH |  | SOLE |  | 10860977 | 0 | 0 |
| SPYGLASS PHARMA INC | COMMON STOCK | 85220G109 | BBG01HDDMDS5 | 207827141 | 8021117 | SH |  | SOLE |  | 8021117 | 0 | 0 |
| TRAVERE THERAPEUTICS INC | COMMON STOCK | 89422G107 | BBG000P9D6W9 | 22188646 | 746841 | SH |  | SOLE |  | 746841 | 0 | 0 |
| TYRA BIOSCIENCES INC | COMMON STOCK | 90240B106 | BBG00RCQD9D1 | 467207338 | 12198625 | SH |  | SOLE |  | 12198625 | 0 | 0 |
| VAXCYTE INC | COMMON STOCK | 92243G108 | BBG009PHHPL8 | 666788948 | 11474599 | SH |  | SOLE |  | 11474599 | 0 | 0 |
| WEREWOLF THERAPEUTICS INC | COMMON STOCK | 95075A107 | BBG00QXQ9XK4 | 5562856 | 6681307 | SH |  | SOLE |  | 6681307 | 0 | 0 |
| XENCOR INC | COMMON STOCK | 98401F105 | BBG0026ZG4W0 | 59060678 | 4897237 | SH |  | SOLE |  | 4897237 | 0 | 0 |
| ZAI LAB LTD-ADR | COMMON STOCK | 98887Q104 | BBG00HFX3N90 | 107353598 | 5707262 | SH |  | SOLE |  | 5707262 | 0 | 0 |
| GH RESEARCH PLC | COMMON STOCK | G3855L106 | BBG011BQC379 | 107934360 | 7676697 | SH |  | SOLE |  | 7676697 | 0 | 0 |
| PERCEPTIVE CAPITAL SOLUTIONS | COMMON STOCK | G70077105 | BBG01N0FG6L0 | 8227500 | 750000 | SH |  | SOLE |  | 750000 | 0 | 0 |
| WAVE LIFE SCIENCES LTD | COMMON STOCK | Y95308105 | BBG00B642V54 | 195572411 | 26975505 | SH |  | SOLE |  | 26975505 | 0 | 0 |
| HELIX ACQUISITION CORP-CL A | COMMON STOCK | G4444S107 | BBG01YYMT603 | 12700000 | 1250000 | SH |  | SOLE |  | 1250000 | 0 | 0 |
| NEWAMSTERDAM PHARMA CO NV | COMMON STOCK | N62509109 | BBG01BNNTQN4 | 305701614 | 9550191 | SH |  | SOLE |  | 9550191 | 0 | 0 |
| NEWAMSTERDAM PHARMA CO NV-27 | W EXP 99/99/999 | N62509117 | BBG01BNP2MK0 | 6679993 | 333333 | SH |  | SOLE |  | 333333 | 0 | 0 |

---