# EDGAR Filing Document

**Accession Number:** 0001778253
**File Stem:** 0001420506-26-001165
**Filing Date:** 2026-5
**Character Count:** 20233
**Document Hash:** 3a2846018c86cfb4dcc5389e3bd518e9
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001420506-26-001165.hdr.sgml**: 20260515

**ACCESSION NUMBER**: 0001420506-26-001165

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20260331

**FILED AS OF DATE**: 20260515

**DATE AS OF CHANGE**: 20260515

**EFFECTIVENESS DATE**: 20260515

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Ikarian Capital, LLC
- **CENTRAL INDEX KEY:** 0001778253

**ORGANIZATION NAME:**
- **EIN:** 473466768
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-19721
- **FILM NUMBER:** 26988343

**BUSINESS ADDRESS:**
- **STREET 1:** 100 CRESCENT COURT
- **STREET 2:** SUITE 1620
- **CITY:** DALLAS
- **STATE:** TX
- **ZIP:** 75201
- **BUSINESS PHONE:** 214-364-2883

**MAIL ADDRESS:**
- **STREET 1:** 100 CRESCENT COURT
- **STREET 2:** SUITE 1620
- **CITY:** DALLAS
- **STATE:** TX
- **ZIP:** 75201

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 03-31-2026

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** Ikarian Capital LLC<br>**Address:** 100 CRESCENT COURT<br>SUITE 1620<br>DALLAS, TX 75201

**Form 13F File Number:** 028-19721

**SEC File Number (if applicable):** 801-118894

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** Troy Wuertz<br>**Title:** CHIEF COMPLIANCE OFFICER<br>**Phone:** 214-276-0670

**Signature, Place, and Date of Signing:**

Troy Wuertz CHIEF COMPLIANCE OFFICER  DALLAS, TX  05-15-2026<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 0

**Form 13F Information Table Entry Total:** 161

**Form 13F Information Table Value Total:** $1231685555

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

**NONE**

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| ABIVAX SA | SPONSORED ADS | 00370M103 |  | 6232692 | 57635 | SH |  | SOLE |  | 57635 | 0 | 0 |
| ABIVAX SA | SPONSORED ADS | 00370M103 |  | 32658955 | 293300 | SH | Call | SOLE |  | 293300 | 0 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 |  | 625484 | 28099 | SH |  | SOLE |  | 28099 | 0 | 0 |
| ACUMEN PHARMACEUTICALS INC | COM | 00509G209 |  | 2486960 | 1053797 | SH |  | SOLE |  | 1053797 | 0 | 0 |
| ADLAI NORTYE LTD | SPONSORED ADS | 00704R109 |  | 234581 | 33899 | SH |  | SOLE |  | 33899 | 0 | 0 |
| AETHLON MED INC | COM NEW | 00808Y604 |  | 31458 | 14364 | SH |  | SOLE |  | 14364 | 0 | 0 |
| AIRSCULPT TECHNOLOGIES INC | COM | 009496100 |  | 46405 | 16398 | SH |  | SOLE |  | 16398 | 0 | 0 |
| ALECTOR INC | COM | 014442107 |  | 4477603 | 2082606 | SH |  | SOLE |  | 2082606 | 0 | 0 |
| ALPHA COGNITION INC | COM NEW | 02074J501 |  | 5798862 | 1056259 | SH |  | SOLE |  | 1056259 | 0 | 0 |
| ALTO NEUROSCIENCE INC | COM SHS | 02157Q109 |  | 11577200 | 515000 | SH |  | SOLE |  | 515000 | 0 | 0 |
| ALUMIS INC | COM | 022307102 |  | 26734462 | 1213548 | SH |  | SOLE |  | 1213548 | 0 | 0 |
| ALUMIS INC | COM | 022307102 |  | 5829138 | 264600 | SH | Call | SOLE |  | 264600 | 0 | 0 |
| ANI PHARMACEUTICALS INC | COM | 00182C103 |  | 11310837 | 147085 | SH |  | SOLE |  | 147085 | 0 | 0 |
| ANI PHARMACEUTICALS INC | COM | 00182C103 |  | 11535000 | 150000 | SH | Call | SOLE |  | 150000 | 0 | 0 |
| ANNEXON INC | COM | 03589W102 |  | 3214551 | 580244 | SH |  | SOLE |  | 580244 | 0 | 0 |
| ANTERIS TECHNOLOGIES GLOBAL | COM | 03675P102 |  | 2034469 | 366571 | SH |  | SOLE |  | 366571 | 0 | 0 |
| ARROWHEAD PHARMACEUTICALS IN | COM | 04280A100 |  | 3605250 | 57500 | SH | Put | SOLE |  | 57500 | 0 | 0 |
| ARVINAS INC | COM | 04335A105 |  | 3797524 | 358257 | SH |  | SOLE |  | 358257 | 0 | 0 |
| AUTONOMIX MED INC | COM NEW | 05330T205 |  | 7290 | 18688 | SH |  | SOLE |  | 18688 | 0 | 0 |
| AVALO THERAPEUTICS INC | COM NEW | 05338F306 |  | 5994395 | 401500 | SH | Call | SOLE |  | 401500 | 0 | 0 |
| AVALO THERAPEUTICS INC | COM NEW | 05338F306 |  | 2366405 | 158500 | SH | Put | SOLE |  | 158500 | 0 | 0 |
| BIOHAVEN LTD | COM | G1110E107 |  | 3489589 | 412481 | SH |  | SOLE |  | 412481 | 0 | 0 |
| BIOMX INC | COM NEW | 09090D509 |  | 73102 | 19473 | SH |  | SOLE |  | 19473 | 0 | 0 |
| BRIDGEBIO ONCOLOGY THERAPEUT | COM NEW | 107924102 |  | 2418568 | 270231 | SH |  | SOLE |  | 270231 | 0 | 0 |
| BRIDGEBIO PHARMA INC | COM | 10806X102 |  | 11890511 | 160120 | SH |  | SOLE |  | 160120 | 0 | 0 |
| BRIDGEBIO PHARMA INC | COM | 10806X102 |  | 4344210 | 58500 | SH | Call | SOLE |  | 58500 | 0 | 0 |
| BRIGHT MINDS BIOSCIENCES INC | COM NEW | 10919W405 |  | 12160232 | 166647 | SH |  | SOLE |  | 166647 | 0 | 0 |
| BRISTOL-MYERS SQUIBB CO | COM | 110122108 |  | 30325000 | 500000 | SH | Put | SOLE |  | 500000 | 0 | 0 |
| CABALETTA BIO INC | COM | 12674W109 |  | 2421000 | 900000 | SH |  | SOLE |  | 900000 | 0 | 0 |
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 |  | 16051656 | 528015 | SH |  | SOLE |  | 528015 | 0 | 0 |
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 |  | 10640000 | 350000 | SH | Call | SOLE |  | 350000 | 0 | 0 |
| CARDIOL THERAPEUTICS INC | COM CL A | 14161Y200 |  | 3678750 | 2725000 | SH |  | SOLE |  | 2725000 | 0 | 0 |
| CARTESIAN THERAPEUTICS INC | COM NEW | 816212302 |  | 127963 | 20807 | SH |  | SOLE |  | 20807 | 0 | 0 |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 |  | 14630755 | 461247 | SH |  | SOLE |  | 461247 | 0 | 0 |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 |  | 3616080 | 114000 | SH | Put | SOLE |  | 114000 | 0 | 0 |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 |  | 719448 | 18113 | SH |  | SOLE |  | 18113 | 0 | 0 |
| CHEMOMAB THERAPEUTICS LTD | SPONSORED ADS | 16385C203 |  | 81315 | 51793 | SH |  | SOLE |  | 51793 | 0 | 0 |
| CNS PHARMACEUTICALS INC | COM | 18978H508 |  | 109992 | 45830 | SH |  | SOLE |  | 45830 | 0 | 0 |
| COMPASS PATHWAYS PLC | SPONSORED ADS | 20451W101 |  | 3732750 | 675000 | SH |  | SOLE |  | 675000 | 0 | 0 |
| COMPASS THERAPEUTICS INC | COM | 20454B104 |  | 95220 | 18000 | SH |  | SOLE |  | 18000 | 0 | 0 |
| CONNECT BIOPHARMA HLDGS LTD | SHS | G23549101 |  | 13117835 | 5388486 | SH |  | SOLE |  | 5388486 | 0 | 0 |
| CONNECT BIOPHARMA HLDGS LTD | SHS | G23549101 |  | 378852 | 144600 | SH | Call | SOLE |  | 144600 | 0 | 0 |
| CONTINEUM THERAPEUTICS INC | CL A | 21217B100 |  | 10550835 | 807874 | SH |  | SOLE |  | 807874 | 0 | 0 |
| CUMBERLAND PHARMACEUTICALS I | COM | 230770109 |  | 1797748 | 553153 | SH |  | SOLE |  | 553153 | 0 | 0 |
| CYBIN INC | COM NEW | 23256X407 |  | 634334 | 132153 | SH |  | SOLE |  | 132153 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 18690231 | 283572 | SH |  | SOLE |  | 283572 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 26917644 | 408400 | SH | Call | SOLE |  | 408400 | 0 | 0 |
| CYTOKINETICS INC | COM NEW | 23282W605 |  | 36283455 | 550500 | SH | Put | SOLE |  | 550500 | 0 | 0 |
| DAMORA THERAPEUTICS INC | COM NEW | 36322Q206 |  | 8694889 | 335710 | SH |  | SOLE |  | 335710 | 0 | 0 |
| DBV TECHNOLOGIES S A | SPONSORED ADS | 23306J309 |  | 2198776 | 525000 | SH |  | SOLE |  | 525000 | 0 | 0 |
| DEFINIUM THERAPEUTICS INC | COM SHS | 24477V105 |  | 1111377 | 58803 | SH |  | SOLE |  | 58803 | 0 | 0 |
| DELCATH SYS INC | COM NEW | 24661P807 |  | 4002009 | 431251 | SH |  | SOLE |  | 431251 | 0 | 0 |
| DIREXION SHARES ETF TRUST | DAILY S BIOTEC | 25461H853 |  | 1724899 | 105822 | SH |  | SOLE |  | 105822 | 0 | 0 |
| ELI LILLY  CO | COM | 532457108 |  | 6021734 | 6547 | SH |  | SOLE |  | 6547 | 0 | 0 |
| ENLIVEN THERAPEUTICS INC | COM | 29337E102 |  | 3281040 | 83700 | SH | Put | SOLE |  | 83700 | 0 | 0 |
| EQUILLIUM INC | COM | 29446K106 |  | 607110 | 303555 | SH |  | SOLE |  | 303555 | 0 | 0 |
| EUPRAXIA PHARMACEUTICALS INC | COM | 29842P105 |  | 8794726 | 1214741 | SH |  | SOLE |  | 1214741 | 0 | 0 |
| EVAXION AS | SPONSORED ADS | 29970R303 |  | 277876 | 74698 | SH |  | SOLE |  | 74698 | 0 | 0 |
| EYEPOINT INC | COM NEW | 30233G209 |  | 4774456 | 370400 | SH | Call | SOLE |  | 370400 | 0 | 0 |
| EYEPOINT INC | COM NEW | 30233G209 |  | 4774456 | 370400 | SH | Put | SOLE |  | 370400 | 0 | 0 |
| FORTE BIOSCIENCES INC | COM NEW | 34962G208 |  | 3081376 | 118972 | SH |  | SOLE |  | 118972 | 0 | 0 |
| FRACTYL HEALTH INC | COM | 35168W103 |  | 503580 | 1100000 | SH |  | SOLE |  | 1100000 | 0 | 0 |
| FULCRUM THERAPEUTICS INC | COM | 359616109 |  | 8047065 | 1049161 | SH |  | SOLE |  | 1049161 | 0 | 0 |
| GLUCOTRACK INC | COM NEW | 45824Q804 |  | 29790 | 45830 | SH |  | SOLE |  | 45830 | 0 | 0 |
| HARROW INC | COM | 415858109 |  | 19147837 | 543047 | SH |  | SOLE |  | 543047 | 0 | 0 |
| HYPERLIQUID STRATEGIES INC | COM | 44916Y106 |  | 152705 | 30001 | SH |  | SOLE |  | 30001 | 0 | 0 |
| IBIO INC | COM NEW | 451033708 |  | 1818418 | 957062 | SH |  | SOLE |  | 957062 | 0 | 0 |
| IMMATICS N.V | SHS | N44445109 |  | 477919 | 48569 | SH |  | SOLE |  | 48569 | 0 | 0 |
| IMMUNIC INC | COM | 4525EP101 |  | 748876 | 674662 | SH |  | SOLE |  | 674662 | 0 | 0 |
| INSMED INC | COM PAR $.01 | 457669307 |  | 689074 | 4214 | SH |  | SOLE |  | 4214 | 0 | 0 |
| INVENTIVA SA | ADS | 46124U107 |  | 7842781 | 1429101 | SH |  | SOLE |  | 1429101 | 0 | 0 |
| INVESCO QQQ TR | UNIT SER 1 | 46090E103 |  | 57718000 | 100000 | SH | Put | SOLE |  | 100000 | 0 | 0 |
| INVIVYD INC | COM | 00534A102 |  | 3453542 | 2656570 | SH |  | SOLE |  | 2656570 | 0 | 0 |
| IO BIOTECH INC | COM | 449778109 |  | 81391 | 1386565 | SH |  | SOLE |  | 1386565 | 0 | 0 |
| IONIS PHARMACEUTICALS INC | COM | 462222100 |  | 9539284 | 127038 | SH |  | SOLE |  | 127038 | 0 | 0 |
| IONIS PHARMACEUTICALS INC | COM | 462222100 |  | 8417589 | 112100 | SH | Call | SOLE |  | 112100 | 0 | 0 |
| ISHARES TR | RUSSELL 2000 ETF | 464287655 |  | 49600000 | 200000 | SH | Put | SOLE |  | 200000 | 0 | 0 |
| JADE BIOSCIENCES INC | COM NEW | 008064206 |  | 7198503 | 512349 | SH |  | SOLE |  | 512349 | 0 | 0 |
| JASPER THERAPEUTICS INC | COM NEW | 471871202 |  | 21110 | 24093 | SH |  | SOLE |  | 24093 | 0 | 0 |
| JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 |  | 2355563 | 12460 | SH |  | SOLE |  | 12460 | 0 | 0 |
| JOURNEY MED CORP | COM | 48115J109 |  | 1179235 | 251436 | SH |  | SOLE |  | 251436 | 0 | 0 |
| KALARIS THERAPEUTICS INC | COM | 482929106 |  | 2077200 | 360000 | SH |  | SOLE |  | 360000 | 0 | 0 |
| KALVISTA PHARMACEUTICALS INC | COM | 483497103 |  | 706946 | 35119 | SH |  | SOLE |  | 35119 | 0 | 0 |
| KARYOPHARM THERAPEUTICS INC | COM NEW | 48576U205 |  | 4085233 | 733435 | SH |  | SOLE |  | 733435 | 0 | 0 |
| KARYOPHARM THERAPEUTICS INC | COM NEW | 48576U205 |  | 5124400 | 920000 | SH | Call | SOLE |  | 920000 | 0 | 0 |
| KARYOPHARM THERAPEUTICS INC | COM NEW | 48576U205 |  | 5124400 | 920000 | SH | Put | SOLE |  | 920000 | 0 | 0 |
| KEZAR LIFE SCIENCES INC | COM NEW | 49372L209 |  | 758405 | 102211 | SH |  | SOLE |  | 102211 | 0 | 0 |
| KODIAK SCIENCES INC | COM | 50015M109 |  | 48252106 | 1265795 | SH |  | SOLE |  | 1265795 | 0 | 0 |
| KODIAK SCIENCES INC | COM | 50015M109 |  | 3812000 | 100000 | SH | Call | SOLE |  | 100000 | 0 | 0 |
| KYMERA THERAPEUTICS INC | COM | 501575104 |  | 4197816 | 50400 | SH | Put | SOLE |  | 50400 | 0 | 0 |
| LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 |  | 4104404 | 226888 | SH |  | SOLE |  | 226888 | 0 | 0 |
| LEXEO THERAPEUTICS INC | COM | 52886X107 |  | 2944683 | 513011 | SH |  | SOLE |  | 513011 | 0 | 0 |
| LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 |  | 256892 | 164674 | SH |  | SOLE |  | 164674 | 0 | 0 |
| LIPOCINE INC NEW | COM NEW | 53630X203 |  | 4063362 | 508556 | SH |  | SOLE |  | 508556 | 0 | 0 |
| LYELL IMMUNOPHARMA INC | COM NEW | 55083R203 |  | 824084 | 41081 | SH |  | SOLE |  | 41081 | 0 | 0 |
| MACROGENICS INC | COM | 556099109 |  | 216441 | 74893 | SH |  | SOLE |  | 74893 | 0 | 0 |
| MANGOCEUTICALS INC | COM NEW | 56270V205 |  | 49747 | 138146 | SH |  | SOLE |  | 138146 | 0 | 0 |
| MAZE THERAPEUTICS INC | COM | 578784100 |  | 11313120 | 378999 | SH |  | SOLE |  | 378999 | 0 | 0 |
| MAZE THERAPEUTICS INC | COM | 578784100 |  | 429840 | 14400 | SH | Put | SOLE |  | 14400 | 0 | 0 |
| NEUMORA THERAPEUTICS INC. | COM | 640979100 |  | 2492896 | 1278408 | SH |  | SOLE |  | 1278408 | 0 | 0 |
| NEUPHORIA THERAPEUTICS INC | COM | 64136E102 |  | 193093 | 47443 | SH |  | SOLE |  | 47443 | 0 | 0 |
| NEURONETICS INC | COM | 64131A105 |  | 1016714 | 701182 | SH |  | SOLE |  | 701182 | 0 | 0 |
| NEXTCURE INC | COM NEW | 65343E207 |  | 2506947 | 238303 | SH |  | SOLE |  | 238303 | 0 | 0 |
| NOVO-NORDISK A S | ADR | 670100205 |  | 14700000 | 400000 | SH | Call | SOLE |  | 400000 | 0 | 0 |
| NUVALENT INC | COM | 670703107 |  | 2417206 | 23594 | SH |  | SOLE |  | 23594 | 0 | 0 |
| NYXOAH S A | SHS | B6S7WD106 |  | 138285 | 47358 | SH |  | SOLE |  | 47358 | 0 | 0 |
| OCUGEN INC | COM | 67577C105 |  | 7172979 | 3962972 | SH |  | SOLE |  | 3962972 | 0 | 0 |
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 |  | 8920370 | 598281 | SH |  | SOLE |  | 598281 | 0 | 0 |
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 |  | 8197518 | 549800 | SH | Call | SOLE |  | 549800 | 0 | 0 |
| ORUKA THERAPEUTICS INC | COM | 687604108 |  | 11871130 | 242021 | SH |  | SOLE |  | 242021 | 0 | 0 |
| OVID THERAPEUTICS INC | COM | 690469101 |  | 6426242 | 2894704 | SH |  | SOLE |  | 2894704 | 0 | 0 |
| PALISADE BIO INC | COM | 696389402 |  | 481212 | 274978 | SH |  | SOLE |  | 274978 | 0 | 0 |
| PALVELLA THERAPEUTICS INC NE | COM | 697947109 |  | 8055631 | 64626 | SH |  | SOLE |  | 64626 | 0 | 0 |
| PASSAGE BIO INC | COM NEW | 702712209 |  | 534773 | 68124 | SH |  | SOLE |  | 68124 | 0 | 0 |
| PELTHOS THERAPEUTICS INC | COM SHS | 171126204 |  | 5391124 | 256598 | SH |  | SOLE |  | 256598 | 0 | 0 |
| PEPGEN INC | COM | 713317105 |  | 791482 | 447165 | SH |  | SOLE |  | 447165 | 0 | 0 |
| PEPGEN INC | COM | 713317105 |  | 531000 | 300000 | SH | Call | SOLE |  | 300000 | 0 | 0 |
| PERCEPTIVE CAP SOLUTIONS COR | CL A ORD SHS | G70077105 |  | 2643232 | 240951 | SH |  | SOLE |  | 240951 | 0 | 0 |
| PHARVARIS N V | COM | N69605108 |  | 13753683 | 486856 | SH |  | SOLE |  | 486856 | 0 | 0 |
| PMV PHARMACEUTICALS INC | COM | 69353Y103 |  | 110529 | 89136 | SH |  | SOLE |  | 89136 | 0 | 0 |
| PRAXIS PRECISION MEDICINES I | COM NEW | 74006W207 |  | 23062682 | 71581 | SH |  | SOLE |  | 71581 | 0 | 0 |
| PROMIS NEUROSCIENCES INC | COM SHS | 74346M505 |  | 698500 | 55000 | SH |  | SOLE |  | 55000 | 0 | 0 |
| PROQR THRAPEUTICS N V | SHS EURO | N71542109 |  | 2417411 | 1492229 | SH |  | SOLE |  | 1492229 | 0 | 0 |
| QUOIN PHARMACEUTICALS LTD | SPONSORED ADS | 74907L409 |  | 1396151 | 211538 | SH |  | SOLE |  | 211538 | 0 | 0 |
| RELMADA THERAPEUTICS INC | COM | 75955J402 |  | 18710978 | 2688359 | SH |  | SOLE |  | 2688359 | 0 | 0 |
| REPLIMUNE GROUP INC | COM | 76029N106 |  | 2295000 | 300000 | SH | Put | SOLE |  | 300000 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 15865561 | 163142 | SH |  | SOLE |  | 163142 | 0 | 0 |
| REVOLUTION MEDICINES INC | COM | 76155X100 |  | 9238750 | 95000 | SH | Put | SOLE |  | 95000 | 0 | 0 |
| REZOLUTE INC | COM NEW | 76200L309 |  | 50261 | 16479 | SH |  | SOLE |  | 16479 | 0 | 0 |
| SANGAMO THERAPEUTICS INC | COM | 800677106 |  | 300890 | 1218671 | SH |  | SOLE |  | 1218671 | 0 | 0 |
| SENSEI BIOTHERAPEUTICS INC | COM NEW | 81728A207 |  | 200184 | 6351 | SH |  | SOLE |  | 6351 | 0 | 0 |
| SHUTTLE PHARMACTCLS HLDGS IN | COM | 825693401 |  | 46832 | 68993 | SH |  | SOLE |  | 68993 | 0 | 0 |
| SILENCE THERAPEUTICS PLC | ADS | 82686Q101 |  | 1731568 | 865784 | SH |  | SOLE |  | 865784 | 0 | 0 |
| SOLENO THERAPEUTICS INC | COM | 834203309 |  | 11521238 | 344123 | SH |  | SOLE |  | 344123 | 0 | 0 |
| SOLID BIOSCIENCES INC | COM NEW | 83422E204 |  | 1903744 | 264409 | SH |  | SOLE |  | 264409 | 0 | 0 |
| SPDR SERIES TRUST | STATE STREET SPD | 78464A870 |  | 102184000 | 800000 | SH | Put | SOLE |  | 800000 | 0 | 0 |
| SPRUCE BIOSCIENCES INC | COM NEW | 85209E208 |  | 7930614 | 121356 | SH |  | SOLE |  | 121356 | 0 | 0 |
| SURROZEN INC | COM NEW | 86889P208 |  | 5042607 | 173107 | SH |  | SOLE |  | 173107 | 0 | 0 |
| TARSUS PHARMACEUTICALS INC | COM | 87650L103 |  | 2186295 | 31166 | SH |  | SOLE |  | 31166 | 0 | 0 |
| TECTONIC THERAPEUTIC INC | COM | 878972108 |  | 4869469 | 157537 | SH |  | SOLE |  | 157537 | 0 | 0 |
| TENAX THERAPEUTICS INC | COM NEW | 88032L605 |  | 16271424 | 1017600 | SH |  | SOLE |  | 1017600 | 0 | 0 |
| TENAX THERAPEUTICS INC | COM NEW | 88032L605 |  | 1827657 | 114300 | SH | Call | SOLE |  | 114300 | 0 | 0 |
| TERNS PHARMACEUTICALS INC | COM | 880881107 |  | 76780248 | 1456378 | SH |  | SOLE |  | 1456378 | 0 | 0 |
| TERNS PHARMACEUTICALS INC | COM | 880881107 |  | 63264000 | 1200000 | SH | Put | SOLE |  | 1200000 | 0 | 0 |
| THERIVA BIOLOGICS INC | COM NEW | 87164U508 |  | 21944 | 112076 | SH |  | SOLE |  | 112076 | 0 | 0 |
| TRAWS PHARMA INC | COM NEW | 68232V884 |  | 1241000 | 678142 | SH |  | SOLE |  | 678142 | 0 | 0 |
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 |  | 10109863 | 482571 | SH |  | SOLE |  | 482571 | 0 | 0 |
| UNIQURE NV | SHS | N90064101 |  | 1488831 | 91060 | SH |  | SOLE |  | 91060 | 0 | 0 |
| UNIQURE NV | CALL | N90064901 |  | 5804250 | 355000 | SH | Call | SOLE |  | 355000 | 0 | 0 |
| VAXCYTE INC | COM | 92243G108 |  | 24910711 | 428682 | SH |  | SOLE |  | 428682 | 0 | 0 |
| VERA THERAPEUTICS INC | CL A | 92337R101 |  | 8045999 | 200000 | SH |  | SOLE |  | 200000 | 0 | 0 |
| VERA THERAPEUTICS INC | CL A | 92337R101 |  | 2884491 | 71700 | SH | Call | SOLE |  | 71700 | 0 | 0 |
| VERASTEM INC | COM NEW | 92337C203 |  | 1133484 | 213865 | SH |  | SOLE |  | 213865 | 0 | 0 |
| VERU INC | COM NEW | 92536C202 |  | 295073 | 133517 | SH |  | SOLE |  | 133517 | 0 | 0 |
| VIKING THERAPEUTICS INC | COM | 92686J106 |  | 316191 | 9717 | SH |  | SOLE |  | 9717 | 0 | 0 |
| VIR BIOTECHNOLOGY INC | COM | 92764N102 |  | 2627591 | 293258 | SH |  | SOLE |  | 293258 | 0 | 0 |
| VISTAGEN THERAPEUTICS INC | COM | 92840H400 |  | 296654 | 519077 | SH |  | SOLE |  | 519077 | 0 | 0 |
| VOYAGER THERAPEUTICS INC | COM | 92915B106 |  | 204823 | 53063 | SH |  | SOLE |  | 53063 | 0 | 0 |
| VYNE THERAPEUTICS INC | COM | 92941V308 |  | 158284 | 264912 | SH |  | SOLE |  | 264912 | 0 | 0 |
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 |  | 618317 | 85285 | SH |  | SOLE |  | 85285 | 0 | 0 |
| ZURA BIO LTD | CLASS A ORD SHS | G9TY5A101 |  | 7101278 | 1193492 | SH |  | SOLE |  | 1193492 | 0 | 0 |

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