# EDGAR Filing Document

**Accession Number:** 0001493215
**File Stem:** 0001493215-25-000009
**Filing Date:** 2025-8
**Character Count:** 31891
**Document Hash:** 5c4772701c068a12ab5ff34d0bd3dc71
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001493215-25-000009.hdr.sgml**: 20250827

**ACCESSION NUMBER**: 0001493215-25-000009

**CONFORMED SUBMISSION TYPE**: N-PX

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20250630

**FILED AS OF DATE**: 20250827

**EFFECTIVENESS DATE**: 20250827

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** RTW INVESTMENTS, LP
- **CENTRAL INDEX KEY:** 0001493215

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** N-PX
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-16670
- **FILM NUMBER:** 251261673

**BUSINESS ADDRESS:**
- **STREET 1:** 40 10TH AVENUE
- **STREET 2:** 7TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10014
- **BUSINESS PHONE:** 646-597-6980

**MAIL ADDRESS:**
- **STREET 1:** 40 10TH AVENUE
- **STREET 2:** 7TH FLOOR
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10014

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** RTW INVESTMENTS, LLC
- **DATE OF NAME CHANGE:** 20100602

## FORM N-PX
### ANNUAL REPORT OF PROXY VOTING RECORD

## N-PX: Filer Information

**Filer CIK:** 0001493215

**Date of Report:** 06/30/2025

**Are you a Registered Management Investment Company or an Institutional Manager?:** Institutional Manager

**Is this a LIVE or TEST Filing?:** LIVE

**Is this an electronic copy of an official filing submitted in paper format?:** [ ]

### Submission Contact Information
_Not provided in this filing._

### Notification Information
**Notify via Filing Website only?:** [ ]

## N-PX: Cover Page

**Name of reporting person:** RTW Investments, LP

**Address:** 40 10th Avenue, Floor 7, New York, NY 10014

**Telephone number:** (646) 597-6980

**Name of agent for service:** —

**Agent Address:** —, —, — —

**Reporting Period:** Report for the year ended 06/30/2025

**SEC File Number:** 028-16670

**CRD Number (if any):** —

**Other SEC File Number (if any):** —

**LEI (if any):** —

**Report Type (check only one):**

Institutional Manager.

- [x] Institutional Manager Voting Report

- [ ] Institutional Manager Notice Report

- [ ] Institutional Manager Combination Report

Registered Management Investment Company.

- [ ] Fund Voting Report

- [ ] Fund Notice Report

**Do you wish to provide explanatory information pursuant to Special Instruction B.4?:**

- [x] No

- [ ] Yes

**Additional information:** —

## N-PX: Summary - Included Managers

**Number of Included Institutional Managers:** 0

**Included Institutional Managers:** —

## FORM N-PX PROXY VOTING RECORD

| NAME OF ISSUER                   | CUSIP     | MEETING DATE   | VOTE DESCRIPTION                                                                                                                                                                                                                    | VOTE CATEGORY                |     SHARES VOTED |   SHARES ON LOAN | HOW VOTED   | SHARES VOTED FOR OR AGAINST MANAGEMENT   | FOR OR AGAINST MANAGEMENT   | OTHER INFO   |
|:---|:---|:---|:---|:---|---:|---:|:---|:---|:---|:---|
| Cutera, Inc.                     | 232109108 | 07/15/2024     | Non-binding advisory vote on the compensation of Named Executive Officers.                                                                                                                                                          | SECTION 14A SAY-ON-PAY VOTES |      1.33178e+06 |                0 | FOR         | 1331776.000000                           | FOR                         |  |
| Avadel Pharmaceuticals Plc       | G29687103 | 07/30/2024     | To approve, on a non-binding advisory basis, the compensation of the named executive officers of the Company                                                                                                                        | SECTION 14A SAY-ON-PAY VOTES |      1.39751e+06 |                0 | FOR         | 1397507.000000                           | FOR                         |  |
| UroGen Pharma Ltd.               | M96088105 | 08/06/2024     | To approve, on an advisory basis, the compensation of the Company's named executive officers, as disclosed in the Company's proxy statement for the Annual Meeting.                                                                 | SECTION 14A SAY-ON-PAY VOTES |      3.55735e+06 |                0 | FOR         | 3557347.000000                           | FOR                         |  |
| ARCA biopharma, Inc.             | 687604108 | 08/22/2024     | To approve, on an advisory basis, certain compensation arrangements for ARCA named executive  officers that are based on or otherwise relate to the Merger;                                                                         | SECTION 14A SAY-ON-PAY VOTES | 949251           |                0 | FOR         | 949251.000000                            | FOR                         |  |
| Roivant Sciences Ltd.            | G76279101 | 09/10/2024     | To cast a non-binding, advisory vote to approve the compensation of our named executive officers.                                                                                                                                   | SECTION 14A SAY-ON-PAY VOTES |      1.45427e+06 |                0 | FOR         | 1454273.000000                           | FOR                         |  |
| Roivant Sciences Ltd.            | G76279101 | 09/10/2024     | To cast a non-binding, advisory vote on the frequency of future non-binding, advisory votes to approve the compensation of our named executive officers every:                                                                      | SECTION 14A SAY-ON-PAY VOTES |      1.45427e+06 |                0 | ONE YEAR    | 1454273.000000                           | FOR                         |  |
| Masimo Corporation               | 574795100 | 09/19/2024     | To provide an advisory vote to approve the compensation of our named executive officers.                                                                                                                                            | SECTION 14A SAY-ON-PAY VOTES |      4.6524e+06  |                0 | FOR         | 4652405.000000                           | FOR                         |  |
| Masimo Corporation               | 574795100 | 09/19/2024     | An advisory vote to approve the compensation of the Company's named executive officers.                                                                                                                                             | SECTION 14A SAY-ON-PAY VOTES |      0           |                0 |  |  |  |  |
| ESSA Pharma Inc.                 | 29668H708 | 03/05/2025     | Advisory Vote on Executive Compensation  The approval, on a non-binding, advisory basis, of the compensation paid to the Company's named executive officers.                                                                        | SECTION 14A SAY-ON-PAY VOTES |      1.07442e+06 |                0 | FOR         | 1074424.000000                           | FOR                         |  |
| Verona Pharma Plc                | 925050106 | 04/24/2025     | To approve, on an advisory (non-binding) basis, the compensation of the Company's named executive officers.                                                                                                                         | SECTION 14A SAY-ON-PAY VOTES |      2.7558e+06  |                0 | FOR         | 2755802.000000                           | FOR                         |  |
| Masimo Corporation               | 574795100 | 04/29/2025     | An advisory vote to approve the compensation of our named executive officers.                                                                                                                                                       | SECTION 14A SAY-ON-PAY VOTES | 681498           |                0 | ABSTAIN     | 681498.000000                            | AGAINST                     |  |
| Intuitive Surgical, Inc.         | 46120E602 | 05/01/2025     | To approve, by advisory vote, the compensation of the Company's Named Executive Officers.                                                                                                                                           | SECTION 14A SAY-ON-PAY VOTES |  44478           |                0 | FOR         | 44478.000000                             | FOR                         |  |
| Stryker Corporation              | 863667101 | 05/08/2025     | Advisory Vote to Approve Named Executive Officer Compensation.                                                                                                                                                                      | SECTION 14A SAY-ON-PAY VOTES | 182603           |                0 | FOR         | 182603.000000                            | FOR                         |  |
| Cytokinetics, Incorporated       | 23282W605 | 05/14/2025     | To approve, on an advisory basis, the compensation of Cytokinetics, Incorporated's named executive officers, as disclosed in the Proxy Statement.                                                                                   | SECTION 14A SAY-ON-PAY VOTES | 705635           |                0 | FOR         | 705635.000000                            | FOR                         |  |
| Immunocore Holdings Plc          | 45258D105 | 05/15/2025     | To approve, on advisory basis, the compensation of the Company's named executive officers, as disclosed in the proxy statement.                                                                                                     | SECTION 14A SAY-ON-PAY VOTES |      2.11754e+06 |                0 | FOR         | 2117543.000000                           | FOR                         |  |
| Insmed Incorporated              | 457669307 | 05/15/2025     | An advisory vote on the 2024 compensation of our named executive officers.                                                                                                                                                          | SECTION 14A SAY-ON-PAY VOTES |      3.01456e+06 |                0 | FOR         | 3014558.000000                           | FOR                         |  |
| Quest Diagnostics Incorporated   | 74834L100 | 05/15/2025     | An advisory resolution to approve the executive officer compensation disclosed in the Company's 2025 proxy statement                                                                                                                | SECTION 14A SAY-ON-PAY VOTES | 310274           |                0 | FOR         | 310274.000000                            | FOR                         |  |
| Ultragenyx Pharmaceutical Inc.   | 90400D108 | 05/15/2025     | Advisory (non-binding) vote to approve the compensation of our named executive officers.                                                                                                                                            | SECTION 14A SAY-ON-PAY VOTES |      1.7074e+06  |                0 | FOR         | 1707402.000000                           | FOR                         |  |
| Alkermes plc                     | G01767105 | 05/21/2025     | To approve, in a non-binding, advisory vote, the compensation of the Company's named executive officers.                                                                                                                            | SECTION 14A SAY-ON-PAY VOTES |      6.8847e+06  |                0 | FOR         | 6884698.000000                           | FOR                         |  |
| Merus N.V.                       | N5749R100 | 05/21/2025     | Approval, on an advisory (non-binding) basis, of the compensation of Merus N.V.'s named executive officers.                                                                                                                         | SECTION 14A SAY-ON-PAY VOTES |      4.16939e+06 |                0 | FOR         | 4169393.000000                           | FOR                         |  |
| Verastem, Inc.                   | 92337C203 | 05/22/2025     | To approve an advisory vote on the compensation of the named executive officers.                                                                                                                                                    | SECTION 14A SAY-ON-PAY VOTES |      4.24548e+06 |                0 | FOR         | 4245476.000000                           | FOR                         |  |
| Establishment Labs Holdings Inc. | G31249108 | 05/23/2025     | To approve, on an advisory basis, the compensation of our named executive officers;                                                                                                                                                 | SECTION 14A SAY-ON-PAY VOTES |      2.56969e+06 |                0 | FOR         | 2569687.000000                           | FOR                         |  |
| 89bio, Inc.                      | 282559103 | 05/28/2025     | Approval of, on an advisory basis, the compensation of the Company's named executive officers.                                                                                                                                      | SECTION 14A SAY-ON-PAY VOTES |      1.96753e+06 |                0 | FOR         | 1967527.000000                           | FOR                         |  |
| GE Healthcare Technologies, Inc. | 36266G107 | 05/28/2025     | Approval of our named executive officers' compensation in an advisory vote.                                                                                                                                                         | SECTION 14A SAY-ON-PAY VOTES | 503010           |                0 | FOR         | 503010.000000                            | FOR                         |  |
| Penumbra, Inc.                   | 70975L107 | 05/28/2025     | To approve, on an advisory basis, the compensation of Penumbra, Inc.'s named executive officers as disclosed in the proxy statement;                                                                                                | SECTION 14A SAY-ON-PAY VOTES | 862770           |                0 | FOR         | 862770.000000                            | FOR                         |  |
| Acadia Pharmaceuticals Inc.      | 004225108 | 05/29/2025     | To approve, on an advisory basis, the compensation of the Company's named executive officers, as disclosed in the proxy statement.                                                                                                  | SECTION 14A SAY-ON-PAY VOTES |      6.82448e+06 |                0 | FOR         | 6824479.000000                           | FOR                         |  |
| Glaukos Corporation              | 377322102 | 05/29/2025     | Approval, on an advisory basis, of the compensation of the Company's named executive officers.                                                                                                                                      | SECTION 14A SAY-ON-PAY VOTES | 190000           |                0 | FOR         | 190000.000000                            | FOR                         |  |
| Spyre Therapeutics, Inc.         | 00773J202 | 05/29/2025     | To approve, on a non-binding, advisory basis, the compensation of the Company's named executive officers.                                                                                                                           | SECTION 14A SAY-ON-PAY VOTES |      3.58373e+06 |                0 | FOR         | 3583727.000000                           | FOR                         |  |
| Dyne Therapeutics, Inc.          | 26818M108 | 05/30/2025     | To vote, on an advisory basis, to approve the compensation of our named executive officers.                                                                                                                                         | SECTION 14A SAY-ON-PAY VOTES |      1.40584e+06 |                0 | FOR         | 1405840.000000                           | FOR                         |  |
| Dyne Therapeutics, Inc.          | 26818M108 | 05/30/2025     | To hold an advisory vote on the frequency of future advisory votes on the compensation of our named executive officers.                                                                                                             | SECTION 14A SAY-ON-PAY VOTES |      1.40584e+06 |                0 | ONE YEAR    | 1405840.000000                           | FOR                         |  |
| Oruka Therapeutics, Inc.         | 687604108 | 06/02/2025     | To approve, on a non-binding, advisory basis, the compensation of our named executive officers.                                                                                                                                     | SECTION 14A SAY-ON-PAY VOTES |  19923           |                0 | FOR         | 19923.000000                             | FOR                         |  |
| Oruka Therapeutics, Inc.         | 687604108 | 06/02/2025     | To vote, on a non-binding, advisory basis, on the frequency of future advisory votes to approve compensation for our named executive officers.                                                                                      | SECTION 14A SAY-ON-PAY VOTES |  19923           |                0 | ONE YEAR    | 19923.000000                             | FOR                         |  |
| Akero Therapeutics, Inc.         | 00973Y108 | 06/03/2025     | To consider and act upon a non-binding, advisory vote to approve the compensation of our named executive officers.                                                                                                                  | SECTION 14A SAY-ON-PAY VOTES |      7.41934e+06 |                0 | FOR         | 7419340.000000                           | FOR                         |  |
| Stoke Therapeutics, Inc.         | 86150R107 | 06/03/2025     | To approve, on an advisory basis, the compensation of the Company's named executive officers.                                                                                                                                       | SECTION 14A SAY-ON-PAY VOTES |      4.97189e+06 |                0 | FOR         | 4971887.000000                           | FOR                         |  |
| Stoke Therapeutics, Inc.         | 86150R107 | 06/03/2025     | To indicate, on an advisory basis, the preferred frequency of future stockholder advisory votes to approve the compensation of the Company's named executive officers.                                                              | SECTION 14A SAY-ON-PAY VOTES |      4.97189e+06 |                0 | ONE YEAR    | 4971887.000000                           | FOR                         |  |
| Beam Therapeutics Inc.           | 07373V105 | 06/04/2025     | Approve, on an advisory basis, the compensation of our named executive officers.                                                                                                                                                    | SECTION 14A SAY-ON-PAY VOTES | 424248           |                0 | FOR         | 424248.000000                            | FOR                         |  |
| Globus Medical, Inc.             | 379577208 | 06/04/2025     | To approve, in an advisory vote, the compensation of the Company's named executive officers (the Say-on-Pay Vote).                                                                                                                  | SECTION 14A SAY-ON-PAY VOTES | 184887           |                0 | FOR         | 184887.000000                            | FOR                         |  |
| Globus Medical, Inc.             | 379577208 | 06/04/2025     | To approve, in an advisory vote, the frequency of the approval, on an advisory basis, of the compensation of our named executive officers (the Frequency Vote).                                                                     | SECTION 14A SAY-ON-PAY VOTES | 184887           |                0 | ONE YEAR    | 184887.000000                            | FOR                         |  |
| Axsome Therapeutics, Inc.        | 05464T104 | 06/06/2025     | To approve, by non-binding advisory vote, the compensation of our named executive officers.                                                                                                                                         | SECTION 14A SAY-ON-PAY VOTES |      2.82671e+06 |                0 | FOR         | 2826708.000000                           | FOR                         |  |
| Avidity Biosciences, Inc.        | 05370A108 | 06/10/2025     | To consider and vote upon, on an advisory basis, the compensation of our named executive officers as disclosed in this proxy statement pursuant to the compensation disclosure rules of the Securities and Exchange Commission; and | SECTION 14A SAY-ON-PAY VOTES |      5.98935e+06 |                0 | FOR         | 5989346.000000                           | FOR                         |  |
| Exagen, Inc.                     | 30068X103 | 06/10/2025     | To approve by an advisory vote the compensation of our named executive officers, as disclosed in the proxy statement; and                                                                                                           | SECTION 14A SAY-ON-PAY VOTES |      1.51187e+06 |                0 | FOR         | 1511866.000000                           | FOR                         |  |
| Exagen, Inc.                     | 30068X103 | 06/10/2025     | To approve by an advisory vote the frequency of holding an advisory vote on compensation of our named executive officers.                                                                                                           | SECTION 14A SAY-ON-PAY VOTES |      1.51187e+06 |                0 | ONE YEAR    | 1511866.000000                           | FOR                         |  |
| Milestone Pharmaceuticals Inc.   | 59935V107 | 06/10/2025     | Say-on-Pay - Approval, on an advisory basis, of the compensation paid to our named executive officers.                                                                                                                              | SECTION 14A SAY-ON-PAY VOTES |      2.5061e+06  |                0 | FOR         | 2506102.000000                           | FOR                         |  |
| Milestone Pharmaceuticals Inc.   | 59935V107 | 06/10/2025     | Say-on-Frequency - Non-binding advisory vote on the frequency of the advisory vote on compensation paid to our named executive officers.                                                                                            | SECTION 14A SAY-ON-PAY VOTES |      2.5061e+06  |                0 | ONE YEAR    | 2506102.000000                           | FOR                         |  |
| RadNet, Inc.                     | 750491102 | 06/10/2025     | An advisory vote to approve the compensation of the Company's Named Executive Officers.                                                                                                                                             | SECTION 14A SAY-ON-PAY VOTES |      1.96297e+06 |                0 | FOR         | 1962973.000000                           | FOR                         |  |
| uniQure N.V.                     | N90064101 | 06/11/2025     | Approval, on an advisory basis, of the compensation of the named executive officers of the Company.                                                                                                                                 | SECTION 14A SAY-ON-PAY VOTES |      4.85332e+06 |                0 | FOR         | 4853319.000000                           | FOR                         |  |
| COMPASS Pathways plc             | 20451W101 | 06/12/2025     | To approve, on a non-binding, advisory basis, the compensation of the Company's named executive officers for the year ended 31 December 2024                                                                                        | SECTION 14A SAY-ON-PAY VOTES |      4.92995e+06 |                0 | FOR         | 4929948.000000                           | FOR                         |  |
| Corvus Pharmaceuticals, Inc.     | 221015100 | 06/12/2025     | To approve, on a non-binding advisory basis, the compensation of our named executive officers                                                                                                                                       | SECTION 14A SAY-ON-PAY VOTES |      2.67948e+06 |                0 | FOR         | 2679479.000000                           | FOR                         |  |
| Cullinan Therapeutics, Inc.      | 230031106 | 06/12/2025     | Proposal to vote, on an advisory basis, to approve our named executive officer compensation.                                                                                                                                        | SECTION 14A SAY-ON-PAY VOTES |      1.70596e+06 |                0 | FOR         | 1705960.000000                           | FOR                         |  |
| Cullinan Therapeutics, Inc.      | 230031106 | 06/12/2025     | Proposal to vote, on an advisory basis, on the frequency of future advisory votes on our named executive officer compensation.                                                                                                      | SECTION 14A SAY-ON-PAY VOTES |      1.70596e+06 |                0 | ONE YEAR    | 1705960.000000                           | FOR                         |  |
| Natera, Inc.                     | 632307104 | 06/12/2025     | To approve, on an advisory (non-binding) basis, the compensation of Natera, Inc.'s named executive officers as disclosed in the proxy statement.                                                                                    | SECTION 14A SAY-ON-PAY VOTES |      2.56712e+06 |                0 | FOR         | 2567116.000000                           | FOR                         |  |
| Neurogene, Inc.                  | 64135M105 | 06/12/2025     | To approve on an an (non-binding) basis the compensation of the Company's named executive officers.                                                                                                                                 | SECTION 14A SAY-ON-PAY VOTES |      1.13366e+06 |                0 | FOR         | 1133656.000000                           | FOR                         |  |
| Tarsus Pharmaceuticals, Inc.     | 87650L103 | 06/12/2025     | To hold an advisory vote to approve, on a non-binding basis, named executive officer compensation.                                                                                                                                  | SECTION 14A SAY-ON-PAY VOTES |      3.21009e+06 |                0 | FOR         | 3210089.000000                           | FOR                         |  |
| Tarsus Pharmaceuticals, Inc.     | 87650L103 | 06/12/2025     | To hold an advisory vote to approve, on a non-binding basis, the frequency with which future stockholder votes on the compensation of our named executive officers will be conducted of one, two or three years.                    | SECTION 14A SAY-ON-PAY VOTES |      3.21009e+06 |                0 | ONE YEAR    | 3210089.000000                           | FOR                         |  |
| Xencor, Inc.                     | 98401F105 | 06/12/2025     | To approve, on an advisory (non-binding) basis, the compensation of the Company's named executive officers, as disclosed in the accompanying Proxy Statement;                                                                       | SECTION 14A SAY-ON-PAY VOTES |      2.32394e+06 |                0 | FOR         | 2323941.000000                           | FOR                         |  |
| Apogee Therapeutics, Inc.        | 03770N101 | 06/17/2025     | Vote on the frequency of future advisory votes to approve our named executive officers compensation.                                                                                                                                | SECTION 14A SAY-ON-PAY VOTES |      2.7121e+06  |                0 | ONE YEAR    | 2712097.000000                           | FOR                         |  |
| PTC Therapeutics, Inc.           | 69366J200 | 06/17/2025     | Approval on a non-binding, advisory basis, of the Company's named executive officer compensation as described in the proxy statement.                                                                                               | SECTION 14A SAY-ON-PAY VOTES |      7.54642e+06 |                0 | FOR         | 7546415.000000                           | FOR                         |  |
| Rocket Pharmaceuticals, Inc.     | 77313F106 | 06/18/2025     | Consider and act upon a non-binding, advisory vote on the compensation of our named executive officers;                                                                                                                             | SECTION 14A SAY-ON-PAY VOTES |      1.67342e+07 |                0 | FOR         | 16734217.000000                          | FOR                         |  |
| Zai Lab Limited                  | 98887Q104 | 06/18/2025     | THAT, on an advisory basis, the compensation of the Company's named executive officers, as disclosed in the proxy statement, is hereby approved.                                                                                    | SECTION 14A SAY-ON-PAY VOTES |      1.82622e+06 |                0 | FOR         | 1826218.000000                           | FOR                         |  |
| Madrigal Pharmaceuticals, Inc.   | 558868105 | 06/20/2025     | Advisory vote to approve executive compensation                                                                                                                                                                                     | SECTION 14A SAY-ON-PAY VOTES |      1.99369e+06 |                0 | FOR         | 1993687.000000                           | FOR                         |  |
| Madrigal Pharmaceuticals, Inc.   | 558868105 | 06/20/2025     | Advisory vote to approve the frequency of future advisory votes to approve executive compensation                                                                                                                                   | SECTION 14A SAY-ON-PAY VOTES |      1.99369e+06 |                0 | ONE YEAR    | 1993687.000000                           | FOR                         |  |
| Protagonist Therapeutics, Inc.   | 74366E102 | 06/20/2025     | To approve, on a non-binding, advisory basis, the compensation of the Company's named executive officers.                                                                                                                           | SECTION 14A SAY-ON-PAY VOTES |      5.6858e+06  |                0 | FOR         | 5685801.000000                           | FOR                         |  |
| Arvinas, Inc.                    | 04335A105 | 06/25/2025     | To approve, on an advisory basis, the compensation of the Company's named executive officers.                                                                                                                                       | SECTION 14A SAY-ON-PAY VOTES |      3.33034e+06 |                0 | FOR         | 3330343.000000                           | FOR                         |  |

## N-PX: Signature Block

**Reporting Person:** RTW Investments, LP

**By (Signature):** Abdi Moazami

**By (Printed Signature):** Abdi Moazami

**By (Title):** Director of Compliance

**Date:** 08/27/2025