# EDGAR Filing Document

**Accession Number:** 0001425738
**File Stem:** 0001104659-23-021706
**Filing Date:** 2023-2
**Character Count:** 25724
**Document Hash:** 2971c7551b93382befe90d56e2b17e6f
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-23-021706.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001104659-23-021706

**CONFORMED SUBMISSION TYPE**: SC 13G/A

**PUBLIC DOCUMENT COUNT**: 2

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**GROUP MEMBERS**: JEREMY C. GREEN

**GROUP MEMBERS**: REDMILE BIOPHARMA INVESTMENTS III, L.P.

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Zymeworks Inc.
- **CENTRAL INDEX KEY:** 0001937653
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G/A
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-93790
- **FILM NUMBER:** 23630114

**BUSINESS ADDRESS:**
- **STREET 1:** 108 PATRIOT DRIVE, SUITE A
- **CITY:** MIDDLETOWN
- **STATE:** DE
- **ZIP:** 19709
- **BUSINESS PHONE:** 206-337-1030

**MAIL ADDRESS:**
- **STREET 1:** 108 PATRIOT DRIVE, SUITE A
- **CITY:** MIDDLETOWN
- **STATE:** DE
- **ZIP:** 19709

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Zymeworks Delaware Inc.
- **DATE OF NAME CHANGE:** 20220712
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Redmile Group, LLC
- **CENTRAL INDEX KEY:** 0001425738
- **IRS NUMBER:** 208592298
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G/A

**BUSINESS ADDRESS:**
- **STREET 1:** ONE LETTERMAN DRIVE
- **STREET 2:** BUILDING D, SUITE D3-300
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94129
- **BUSINESS PHONE:** 415-489-9980

**MAIL ADDRESS:**
- **STREET 1:** ONE LETTERMAN DRIVE
- **STREET 2:** BUILDING D, SUITE D3-300
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94129

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**SCHEDULE 13G**

**Under the Securities Exchange Act of 1934**

**(Amendment No. 1)**

**Zymeworks Inc.**

------

(Name of Issuer)

**Common Stock, par value $0.00001 per share**

------

(Title of Class of Securities)

**98985Y108**

(CUSIP Number)

**December 31, 2022**

------

**(Date of Event Which Requires Filing of this Statement)**

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

◻ Rule 13d-1(b)

⌧Rule 13d-1(c)

◻ Rule 13d-1(d)

\* The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

**CUSIP No.** **98985Y108**

---

| | | | |
|:---|:---|:---|:---|
| &nbsp;&nbsp;**1** | &nbsp;&nbsp; Name of Reporting Person<br>**Redmile Group, LLC** | &nbsp;&nbsp; Name of Reporting Person<br>**Redmile Group, LLC** | &nbsp;&nbsp; Name of Reporting Person<br>**Redmile Group, LLC** |
| &nbsp;&nbsp;**2** | &nbsp;&nbsp; Check the Appropriate Box if a Member of a Group (See Instructions)<br>(a) ◻<br> (b) ◻ | &nbsp;&nbsp; Check the Appropriate Box if a Member of a Group (See Instructions)<br>(a) ◻<br> (b) ◻ | &nbsp;&nbsp; Check the Appropriate Box if a Member of a Group (See Instructions)<br>(a) ◻<br> (b) ◻ |
| &nbsp;&nbsp;**3** | &nbsp;&nbsp;SEC Use Only | &nbsp;&nbsp;SEC Use Only | &nbsp;&nbsp;SEC Use Only |
| &nbsp;&nbsp;**4** | &nbsp;&nbsp; Citizenship or Place of Organization<br>**Delaware** | &nbsp;&nbsp; Citizenship or Place of Organization<br>**Delaware** | &nbsp;&nbsp; Citizenship or Place of Organization<br>**Delaware** |
| &nbsp;&nbsp; <br> **number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp; <br> **number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp;**5** | &nbsp;&nbsp; Sole Voting Power<br>**0** |
| &nbsp;&nbsp; <br> **number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp; <br> **number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp;**6** | &nbsp;&nbsp; Shared Voting Power<br>**6,175,918 <sup>(1)</sup>** |
| &nbsp;&nbsp; <br> **number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp; <br> **number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp;**7** | &nbsp;&nbsp; Sole Dispositive Power<br>**0** |
| &nbsp;&nbsp; <br> **number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp; <br> **number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp;**8** | &nbsp;&nbsp; Shared Dispositive Power<br>**6,175,918 <sup>(1)</sup>** |
| &nbsp;&nbsp;**9** | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br>**6,175,918 <sup>(1)</sup>** | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br>**6,175,918 <sup>(1)</sup>** | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br>**6,175,918 <sup>(1)</sup>** |
| &nbsp;&nbsp;**10** | &nbsp;&nbsp;Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ◻ | &nbsp;&nbsp;Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ◻ | &nbsp;&nbsp;Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ◻ |
| &nbsp;&nbsp;**11** | &nbsp;&nbsp; Percent of Class Represented by Amount in Row (9)<br>**9.8%<sup>(2)</sup>** | &nbsp;&nbsp; Percent of Class Represented by Amount in Row (9)<br>**9.8%<sup>(2)</sup>** | &nbsp;&nbsp; Percent of Class Represented by Amount in Row (9)<br>**9.8%<sup>(2)</sup>** |
| &nbsp;&nbsp;**12** | &nbsp;&nbsp; Type of Reporting Person (See Instructions)<br>**IA, OO** | &nbsp;&nbsp; Type of Reporting Person (See Instructions)<br>**IA, OO** | &nbsp;&nbsp; Type of Reporting Person (See Instructions)<br>**IA, OO** |

---

<sup>(1)</sup> Redmile Group, LLC's beneficial ownership of the Issuer's common shares ("Common Stock") is comprised of 6,175,918 shares of Common Stock owned by certain private investment vehicles and/or separately managed accounts managed by Redmile Group, LLC, which shares of Common Stock may be deemed beneficially owned by Redmile Group, LLC as investment manager of such private investment vehicles and/or separately managed accounts. The reported securities may also be deemed beneficially owned by Jeremy C. Green as the principal of Redmile Group, LLC. Redmile Group, LLC and Mr. Green each disclaim beneficial ownership of these shares, except to the extent of its or his pecuniary interest in such shares, if any.

<sup>(2)</sup> Percentage based on 63,003,370 shares of Common Stock outstanding as of November 15, 2022, as reported by the Issuer in its Definitive Proxy Statement on Schedule 14A filed with the Securities and Exchange Commission on November 25, 2022 (the "Schedule 14A").

**CUSIP No. 98985Y108**

---

| | | | |
|:---|:---|:---|:---|
| &nbsp;&nbsp;**1** | &nbsp;&nbsp; Name of Reporting Person<br>**Jeremy C. Green** | &nbsp;&nbsp; Name of Reporting Person<br>**Jeremy C. Green** | &nbsp;&nbsp; Name of Reporting Person<br>**Jeremy C. Green** |
| &nbsp;&nbsp;**2** | &nbsp;&nbsp; Check the Appropriate Box if a Member of a Group (See Instructions)<br>(a) ◻<br> (b) ◻ | &nbsp;&nbsp; Check the Appropriate Box if a Member of a Group (See Instructions)<br>(a) ◻<br> (b) ◻ | &nbsp;&nbsp; Check the Appropriate Box if a Member of a Group (See Instructions)<br>(a) ◻<br> (b) ◻ |
| &nbsp;&nbsp;**3** | &nbsp;&nbsp;SEC Use Only | &nbsp;&nbsp;SEC Use Only | &nbsp;&nbsp;SEC Use Only |
| &nbsp;&nbsp; **4** | &nbsp;&nbsp; Citizenship or Place of Organization<br>**United Kingdom** | &nbsp;&nbsp; Citizenship or Place of Organization<br>**United Kingdom** | &nbsp;&nbsp; Citizenship or Place of Organization<br>**United Kingdom** |
| &nbsp;&nbsp; <br> **number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp; <br> **number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp;**5** | &nbsp;&nbsp; Sole Voting Power<br>**0** |
| &nbsp;&nbsp; <br> **number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp; <br> **number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp;**6** | &nbsp;&nbsp; Shared Voting Power<br>**6,175,918 <sup>(3)</sup>** |
| &nbsp;&nbsp; <br> **number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp; <br> **number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp;**7** | &nbsp;&nbsp; Sole Dispositive Power<br>**0** |
| &nbsp;&nbsp; <br> **number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp; <br> **number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp;**8** | &nbsp;&nbsp; Shared Dispositive Power<br>**6,175,918 <sup>(3)</sup>** |
| &nbsp;&nbsp;**9** | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br>**6,175,918 <sup>(3)</sup>** | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br>**6,175,918 <sup>(3)</sup>** | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br>**6,175,918 <sup>(3)</sup>** |
| &nbsp;&nbsp;**10** | &nbsp;&nbsp;Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ◻ | &nbsp;&nbsp;Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ◻ | &nbsp;&nbsp;Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ◻ |
| &nbsp;&nbsp;**11** | &nbsp;&nbsp; Percent of Class Represented by Amount in Row (9)<br>**9.8%<sup>(4)</sup>** | &nbsp;&nbsp; Percent of Class Represented by Amount in Row (9)<br>**9.8%<sup>(4)</sup>** | &nbsp;&nbsp; Percent of Class Represented by Amount in Row (9)<br>**9.8%<sup>(4)</sup>** |
| &nbsp;&nbsp;**12** | &nbsp;&nbsp; Type of Reporting Person (See Instructions)<br>**IN, HC** | &nbsp;&nbsp; Type of Reporting Person (See Instructions)<br>**IN, HC** | &nbsp;&nbsp; Type of Reporting Person (See Instructions)<br>**IN, HC** |

---

<sup>(3)</sup> Jeremy C. Green's beneficial ownership of the Common Stock is comprised of 6,175,918 shares of Common Stock owned by certain private investment vehicles and/or separately managed accounts managed by Redmile Group, LLC, which shares of Common Stock may be deemed beneficially owned by Redmile Group, LLC as investment manager of such private investment vehicles and/or separately managed accounts. The reported securities may also be deemed beneficially owned by Jeremy C. Green as the principal of Redmile Group, LLC. Redmile Group, LLC and Mr. Green each disclaim beneficial ownership of these shares, except to the extent of its or his pecuniary interest in such shares, if any.

<sup>(4)</sup> Percentage based on 63,003,370 shares of Common Stock outstanding as of November 15, 2022, as reported by the Issuer in the Schedule 14A.

**CUSIP No.** **98985Y108**

---

| | | | |
|:---|:---|:---|:---|
| &nbsp;&nbsp;**1** | &nbsp;&nbsp; Name of Reporting Person<br>**Redmile Biopharma Investments III, L.P.** | &nbsp;&nbsp; Name of Reporting Person<br>**Redmile Biopharma Investments III, L.P.** | &nbsp;&nbsp; Name of Reporting Person<br>**Redmile Biopharma Investments III, L.P.** |
| &nbsp;&nbsp;**2** | &nbsp;&nbsp; Check the Appropriate Box if a Member of a Group (See Instructions)<br>(a) ◻<br> (b) ◻ | &nbsp;&nbsp; Check the Appropriate Box if a Member of a Group (See Instructions)<br>(a) ◻<br> (b) ◻ | &nbsp;&nbsp; Check the Appropriate Box if a Member of a Group (See Instructions)<br>(a) ◻<br> (b) ◻ |
| &nbsp;&nbsp;**3** | &nbsp;&nbsp;SEC Use Only | &nbsp;&nbsp;SEC Use Only | &nbsp;&nbsp;SEC Use Only |
| &nbsp;&nbsp; <br> **4** | &nbsp;&nbsp; Citizenship or Place of Organization<br>**Delaware** | &nbsp;&nbsp; Citizenship or Place of Organization<br>**Delaware** | &nbsp;&nbsp; Citizenship or Place of Organization<br>**Delaware** |
| &nbsp;&nbsp; <br>**number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp; <br>**number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp;**5** | &nbsp;&nbsp; Sole Voting Power<br>**0**  |
| &nbsp;&nbsp; <br>**number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp; <br>**number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp;**6** | &nbsp;&nbsp; Shared Voting Power<br>**3,470,727** |
| &nbsp;&nbsp; <br>**number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp; <br>**number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp;**7** | &nbsp;&nbsp; Sole Dispositive Power<br>**0** |
| &nbsp;&nbsp; <br>**number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp; <br>**number of<br> shares<br> beneficially<br> owned by<br> each<br> reporting<br> person with** | &nbsp;&nbsp;**8** | &nbsp;&nbsp; Shared Dispositive Power<br>**3,470,727** |
| &nbsp;&nbsp;**9** | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br>**3,470,727** | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br>**3,470,727** | &nbsp;&nbsp; Aggregate Amount Beneficially Owned by Each Reporting Person<br>**3,470,727** |
| &nbsp;&nbsp;**10** | &nbsp;&nbsp; Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ◻  | &nbsp;&nbsp; Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ◻  | &nbsp;&nbsp; Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ◻  |
| &nbsp;&nbsp;**11** | &nbsp;&nbsp; Percent of Class Represented by Amount in Row (9)<br>**5.5% <sup>(5)</sup>** | &nbsp;&nbsp; Percent of Class Represented by Amount in Row (9)<br>**5.5% <sup>(5)</sup>** | &nbsp;&nbsp; Percent of Class Represented by Amount in Row (9)<br>**5.5% <sup>(5)</sup>** |
| &nbsp;&nbsp;**12** | &nbsp;&nbsp; Type of Reporting Person (See Instructions)<br>**PN** | &nbsp;&nbsp; Type of Reporting Person (See Instructions)<br>**PN** | &nbsp;&nbsp; Type of Reporting Person (See Instructions)<br>**PN** |

---

<sup>(5)</sup> Percentage based on 63,003,370 shares of Common Stock outstanding as of November 15, 2022, as reported by the Issuer in the Schedule 14A.

**Item 1.**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Name of Issuer

Zymeworks Inc.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Address of Issuer's Principal Executive Offices

108 Patriot Drive, Suite A

Middletown, Delaware 19709

**Item 2.**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Names of Persons Filing

Redmile Group, LLC<br> Jeremy C. Green

Redmile Biopharma Investments III, L.P.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Address of Principal Business office or, if None, Residence

Redmile Group, LLC<br> One Letterman Drive<br> Building D, Suite D3-300<br> The Presidio of San Francisco<br> San Francisco, California 94129

Jeremy C. Green<br> c/o Redmile Group, LLC (NY Office)<br> 45 W. 27th Street, Floor 11<br> New York, NY 10001

Redmile Biopharma Investments III, L.P.

c/o Redmile Group, LLC<br> One Letterman Drive<br> Building D, Suite D3-300<br> The Presidio of San Francisco<br> San Francisco, California 94129

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Citizenship

Redmile Group, LLC: Delaware<br> Jeremy C. Green: United Kingdom

Redmile Biopharma Investments III, L.P.: Delaware

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) Title of Class of Securities

Common Stock, par value $0.00001 per share

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) CUSIP Number

98985Y108

**Item 3.** If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) ◻ Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) ◻ Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) ◻ Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) ◻ Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C 80a-8);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(e) ◻ An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(f) ◻ An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(g) ◻ A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(h) ◻ A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) ◻ A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940
(15 U.S.C. 80a-3);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(j) ◻ A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J);

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(k) ◻ Group, in accordance with § 240.13d-1(b)(1)(ii)(K). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
please specify the type of institution: __________

**Item 4.** **Ownership.**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Amount beneficially owned:

Redmile Group, LLC – 6,175,918 (1)<br> Jeremy C. Green – 6,175,918 (1)

Redmile Biopharma Investments III, L.P. – 3,470,727

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) Percent of class:

Redmile Group, LLC – 9.8% (2)

Jeremy C. Green – 9.8% (2)

Redmile Biopharma Investments III, L.P. – 5.5% (2)

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c) Number of shares as to which Redmile Group, LLC has:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) Sole power to vote or to direct the vote:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) Shared power to vote or to direct the vote:

6,175,918 (1)

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) Sole power to dispose or to direct the disposition of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) Shared power to dispose or to direct the disposition of:

6,175,918 (1)

Number of shares as to which Jeremy C. Green has:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) Sole power to vote or to direct the vote:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) Shared power to vote or to direct the vote:

6,175,918 (1)

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) Sole power to dispose or to direct the disposition of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) Shared power to dispose or to direct the disposition of:

6,175,918 (1)

Number of shares as to which Redmile Biopharma Investments III, L.P. has:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i) Sole power to vote or to direct the vote:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii) Shared power to vote or to direct the vote:

3,470,727

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii) Sole power to dispose or to direct the disposition of:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv) Shared power to dispose or to direct the disposition of:

3,470,727

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1) The Issuer's
common shares reported herein are held by certain private investment vehicles and/or separately managed accounts, including Redmile Biopharma
Investments III, L.P. (collectively, the "Redmile Clients"), for which Redmile Group, LLC is the investment manager/adviser
and, in such capacity, exercises sole voting and investment power over all of the common shares held by the Redmile Clients and may be
deemed to be the beneficial owner of these shares. Jeremy C. Green serves as the principal of Redmile Group, LLC and also may be deemed
to be the beneficial owner of these shares. Redmile Group, LLC and Mr. Green each disclaim beneficial ownership of these shares, except
to the extent of its or his pecuniary interest in such shares, if any.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2) Percentage based
on 63,003,370 shares of Common Stock outstanding as of November 15, 2022, as reported by the Issuer in the Schedule 14A.

**Item 5.** **Ownership of Five Percent or Less of a Class.**

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than 5 percent of the class of securities, check the following ◻

**Item 6.** **Ownership of More than Five Percent on Behalf of Another Person.**

N/A.

**Item 7.** **Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.**

See the response to Item 4.

**Item 8.** **Identification and Classification of Members of the Group.**

N/A

**Item 9.** **Notice of Dissolution of Group.**

N/A

**Item 10.** **Certifications.**

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

**SIGNATURE**

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Date: February 14, 2023

---

| | |
|:---|:---|
| **Redmile Group, LLC** | **Redmile Group, LLC** |
| By: | /s/ Jeremy C. Green |
|  | Name: Jeremy C. Green |
|  | Title: Managing Member |

---

---

| | |
|:---|:---|
|  | /s/ Jeremy C. Green |
|  | **Jeremy C. Green** |
| **Redmile Biopharma Investments III, L.P.** | **Redmile Biopharma Investments III, L.P.** |
| By: Redmile Biopharma Investments III (GP), LLC, its general partner | By: Redmile Biopharma Investments III (GP), LLC, its general partner |
| By: | /s/ Jeremy C. Green |
|  | Name: Jeremy C. Green |
|  | Title: Managing Member |

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## Exhibit 99.1

**Exhibit 99.1**

**Joint Filing Agreement**

In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended (the "<u>Exchange Act</u>"), the undersigned hereby agree to the joint filing on behalf of each of them of a Statement on Schedule 13G (including any and all amendments thereto, the "<u>Schedule 13G</u>") relating to the Common Stock of Zymeworks Inc., which may be deemed necessary pursuant to Regulation 13D or 13G promulgated under the Exchange Act.

The undersigned further agree that each party hereto is responsible for the timely filing of the Schedule 13G, and for the accuracy and completeness of the information concerning such party contained therein; provided, however, that no party is responsible for the accuracy or completeness of the information concerning any other party, unless such party knows or has a reason to believe that such information is inaccurate.

It is understood and agreed that a copy of this Joint Filing Agreement shall be attached as an exhibit to the Schedule 13G, filed on behalf of each of the parties hereto.

**IN WITNESS WHEREOF**, each of the undersigned has executed this Joint Filing Agreement as of the 14th day of February, 2023.

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| |
|:---|
| **REDMILE GROUP, LLC** |
| /s/ Jeremy C. Green |
| Name: Jeremy C. Green |
| Title: Managing Member |

---

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| |
|:---|
| /s/ Jeremy C. Green |
| **JEREMY C. GREEN** |
| **REDMILE BIOPHARMA INVESTMENTS III, L.P.** |
| By: Redmile Biopharma Investments III (GP), LLC, its general partner |
| /s/ Jeremy C. Green |
| Name: Jeremy C. Green |
| Title: Managing Member |

---