# EDGAR Filing Document

**Accession Number:** 0001746541
**File Stem:** 0001520262-25-000004
**Filing Date:** 2025-9
**Character Count:** 9844
**Document Hash:** 7b1556049358d2ba47e0f7b290338678
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001520262-25-000004.hdr.sgml**: 20250923

**ACCESSION NUMBER**: 0001520262-25-000004

**CONFORMED SUBMISSION TYPE**: 3

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20250915

**FILED AS OF DATE**: 20250923

**DATE AS OF CHANGE**: 20250923

**REPORTING-OWNER**: 

**OWNER DATA:**
- **COMPANY CONFORMED NAME:** Reed Joshua
- **CENTRAL INDEX KEY:** 0001746541

**ORGANIZATION NAME:**

**FILING VALUES:**
- **FORM TYPE:** 3
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-35299
- **FILM NUMBER:** 251334945

**MAIL ADDRESS:**
- **STREET 1:** C/O ALDEYRA THERAPEUTICS, INC.
- **STREET 2:** 131 HARTWELL AVENUE, SUITE 320
- **CITY:** LEXINGTON
- **STATE:** MA
- **ZIP:** 02421
**ISSUER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Alkermes plc.
- **CENTRAL INDEX KEY:** 0001520262
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 981007018
- **FISCAL YEAR END:** 1231

**BUSINESS ADDRESS:**
- **STREET 1:** CONNAUGHT HOUSE
- **STREET 2:** 1 BURLINGTON ROAD
- **CITY:** DUBLIN 4
- **STATE:** L2
- **ZIP:** 00000
- **BUSINESS PHONE:** 00-353-1-772-8000

**MAIL ADDRESS:**
- **STREET 1:** CONNAUGHT HOUSE
- **STREET 2:** 1 BURLINGTON ROAD
- **CITY:** DUBLIN 4
- **STATE:** L2
- **ZIP:** 00000

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ANTLER SCIENCE TWO PLC
- **DATE OF NAME CHANGE:** 20110804

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Antler Science Two Ltd
- **DATE OF NAME CHANGE:** 20110509

## Ex-24

```

EXHIBIT 24.1

POWER OF ATTORNEY

KNOW ALL BY THESE PRESENTS, that the undersigned hereby revokes all powers of
attorney relating to the following matters and constitutes and appoints each of
Shantale Greenson, Stephanie Roche, Rob Puopolo and Bridget MacLean, and any
one of them acting singly, as true and lawful attorneys-in-fact and agents,
with the full power of substitution and resubstitution, for the undersigned and
 in the undersigned?s name, place and stead, in any and all capacities (until
revoked in writing) to:

(1) prepare, execute in the undersigned?s name and on the undersigned?s behalf,
 and submit to the U.S. Securities and Exchange Commission (?SEC?) a Form ID,
including amendments thereto, and any other documents necessary or appropriate
to obtain codes and passwords enabling the undersigned to make electronic
filings with the SEC of reports required by Section 16(a) of the Securities
Exchange Act of 1934, as amended (the ?Exchange Act?) or any rules or
regulations of the SEC;

(2) 	prepare, execute, acknowledge, deliver and file for and on behalf of the
undersigned, in the undersigned?s capacity as an officer and/or director of
Alkermes plc, an Irish company, or its subsidiaries (together, the ?Company?),
Forms 3, 4, and 5 (including any amendments thereto) in accordance with
Section 16(a) of the Exchange Act and the rules thereunder;

(3) 	do and perform any and all acts for and on behalf of the undersigned which
 may be necessary or desirable to prepare, execute, acknowledge, deliver and
file any such Form 3, 4, or 5, complete and execute any amendment or amendments
 thereto, and timely file such form with the SEC and any stock exchange or
 similar authority including, if necessary, non-U.S. regulators;

(4) 	seek or obtain, as the undersigned?s representative and on the
undersigned?s behalf, information on transactions in the Company?s securities
from any third party, including without limitation brokers, employee benefit
plan administrators and trustees, and the undersigned hereby authorizes any
such person to release any such information to the undersigned and approves and
 ratifies any such release of information; and

(5) 	perform any and all other acts which in the discretion of such
attorney-in-fact are necessary or desirable for and on behalf of the
undersigned in connection with the foregoing.

The undersigned acknowledges that: (1) this Power of Attorney authorizes, but
does not require, each such attorney-in-fact to act in his or her discretion on
 information provided to such attorney-in-fact without independent verification
 of such information; (2) any documents prepared and/or executed by such
attorney-in-fact on behalf of the undersigned pursuant to this Power of
Attorney will be in such form and will contain such information and disclosure
as such attorney-in-fact, in his or her discretion, deems necessary or
desirable; (3) neither the Company nor such attorneys-in-fact assume any
liability or obligation for the undersigned in connection with the matters
covered hereby, including without limitation (i) any liability for the
undersigned?s responsibility to comply with the requirements of the Exchange
Act, (ii) any liability of the undersigned for any failure to comply with such
requirements, or (iii) any obligation or liability of the undersigned for
profit disgorgement under Section 16(b) of the Exchange Act; and (4) this Power
 of Attorney does not relieve the undersigned from responsibility for
compliance with the undersigned?s obligations under the Exchange Act, including
 without limitation the reporting requirements under Section 16 of the
Exchange Act.

The undersigned undertakes and agrees to indemnify the attorneys-in-fact
against all actions, claims, demands, proceedings, costs, charges, expenses and
 other liabilities whatsoever which may be made against the attorneys-in-fact,
or for which the attorneys-in-fact may become liable, by reason of acting
pursuant to this Power of Attorney and the attorneys-in-fact shall not be
liable to the undersigned for any loss or damage occurring as a result of any
act or omission made by the attorneys-in-fact in good faith by reason of acting
 pursuant to this Power of Attorney.

The undersigned hereby gives and grants the foregoing attorneys-in-fact full
power and authority to do and perform all and every act and thing whatsoever
requisite, necessary or appropriate to be done in and about the foregoing
matters as fully to all intents and purposes as the undersigned might or could
do if present, hereby ratifying all that such attorneys-in-fact of, for and on
behalf of the undersigned, will lawfully do or cause to be done by virtue of
this Power of Attorney.

This Power of Attorney will remain in full force and effect until the
undersigned is no longer required to file Forms 3, 4, and 5 with respect to the
 undersigned?s holdings of and transactions in securities issued by
Alkermes plc, unless earlier revoked by the undersigned in a signed writing
delivered to the foregoing attorneys-in-fact. This Power of Attorney will be
governed by the laws of the State of New York, without regard to its choice of
law provisions.

IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be
executed as of the date set forth below.

Date: 	September 22, 2025

Signed: /s/ Joshua Reed

Name: 	Joshua Reed

```

### UNITED STATES SECURITIES AND EXCHANGE COMMISSION
**Washington, D.C. 20549**

## FORM 3

### INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

---

| | | |
|:---|:---|:---|
| **1. Name and Address of Reporting Person**<sup>*</sup><br>Reed Joshua<br><sub>(Last) (First) (Middle)</sub><br>900 WINTER ST.<br><sub>(Street)</sub><br>WALTHAM, MA 02451<br><sub>(City) (State) (Zip)</sub> | **3. Issuer Name and Ticker or Trading Symbol**<br>Alkermes plc. [ ALKS ] | **5. If Amendment, Date of Original Filed (Month/Day/Year)**<br>  |
| **2. Date of Event Requiring Statement (Month/Day/Year)**<br>2025-09-15 | **4. Relationship of Reporting Person(s) to Issuer**<br>(Check all applicable)<br>[ ] Director   [ ] 10% Owner<br>[X] Officer (give title below)   [ ] Other (specify below)<br>_SVP, Chief Financial Officer_ | **6. Individual or Joint/Group Filing (Check Applicable Line)**<br>[X] Form filed by One Reporting Person<br>[ ] Form filed by More than One Reporting Person |

---

## Table I - Non-Derivative Securities Beneficially Owned

---

|  |  |  |  |
| --- | --- | --- | --- |
| 1. Title of Security | 2. Amount of Securities Beneficially Owned | 3. Ownership Form | 4. Nature of Indirect Beneficial Ownership |

---

## Table II - Derivative Securities Beneficially Owned

---

|  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- |
| 1. Title of Derivative Security | 2. Date Exercisable and Expiration Date (Month/Day/Year) | 2. Date Exercisable and Expiration Date (Month/Day/Year) | 3. Title and Amount of Underlying Securities | 3. Title and Amount of Underlying Securities | 4. Conversion or Exercise Price | 5. Ownership Form | 6. Nature of Indirect Beneficial Ownership |
| 1. Title of Derivative Security | Date Exercisable | Expiration Date | Title | Amount or Number of Shares | 4. Conversion or Exercise Price | 5. Ownership Form | 6. Nature of Indirect Beneficial Ownership |
|  |  |  |  |  |  |  |  |

---

**Remarks:**
EXHIBIT LIST: Exhibit 24.1 - Power of Attorney

**Signature:** /s/ Shantale Greenson, attorney-in-fact for Joshua Reed  
**Date:** 2025-09-23

### Remarks:

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

**Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.**