# EDGAR Filing Document

**Accession Number:** 0001599901
**File Stem:** 0001193125-26-079727
**Filing Date:** 2026-2
**Character Count:** 9764
**Document Hash:** 5698a07fea1d82f48d429e2af7e0bdb6
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-26-079727.hdr.sgml**: 20260227

**ACCESSION NUMBER**: 0001193125-26-079727

**CONFORMED SUBMISSION TYPE**: POSASR

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20260227

**DATE AS OF CHANGE**: 20260227

**EFFECTIVENESS DATE**: 20260227

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Avidity Biosciences, Inc.
- **CENTRAL INDEX KEY:** 0001599901
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 461336960
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** POSASR
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-278469
- **FILM NUMBER:** 26693281

**BUSINESS ADDRESS:**
- **STREET 1:** 3020 CALLAN ROAD
- **CITY:** SAN DIEGO
- **STATE:** CA
- **ZIP:** 92121
- **BUSINESS PHONE:** 858-401-7900

**MAIL ADDRESS:**
- **STREET 1:** 3020 CALLAN ROAD
- **CITY:** SAN DIEGO
- **STATE:** CA
- **ZIP:** 92121

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Avidity Biosciences LLC
- **DATE OF NAME CHANGE:** 20161227

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Avidity NanoMedicines LLC
- **DATE OF NAME CHANGE:** 20140211

**As filed with the Securities and Exchange Commission on February 27, 2026** 

**Registration No. 333-277481** 

**Registration No. 333-278469** 

**Registration No. 333-279264** 

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**Washington, D.C. 20549** 

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-3 REGISTRATION STATEMENT NO. 333-277481** 

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-3 REGISTRATION STATEMENT NO. 333-278469** 

**POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-3 REGISTRATION STATEMENT NO. 333-279264** 

***UNDER***

***THE SECURITIES ACT OF 1933***

## AVIDITY BIOSCIENCES, INC.
**(Exact name of registrant as specified in its charter)** 

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| | |
|:---|:---|
| **Delaware** | **46-1336960** |
| **(State or other jurisdiction of**<br> **incorporation or organization)** | **(I.R.S. Employer**<br> **Identification No.)** |

---

**3020 Callan Road** 

**San Diego, California** 

**92121** 

**(858) 401-7900** 

**(Address, including zip code, and telephone number, including area code, of registrant's principal executive offices)** 

**Jaime Huertas** 

**Secretary** 

**Avidity Biosciences, Inc.** 

**3020 Callan Road** 

**San Diego, California 92121** 

**(Name and address of agent for service)** 

**(858) 401-7900** 

**(Name, address, including zip code, and telephone number, including area code, of agent for service)** 

***Copy to:***

**Catherine J. Dargan, Esq.** 

**Michael J. Riella, Esq.** 

**Kerry S. Burke, Esq.** 

**Alicia Zhang, Esq.** 

**Covington & Burling LLP** 

**One CityCenter** 

**850 Tenth Street, NW** 

**Washington, DC 20001-4956** 

**+1 (202) 662-6000** 

**(Approximate date of commencement of proposed sale to the public)**: Not applicable.

If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box: ☐

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box: ☐

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐

If this Form is a registration statement pursuant to General Instruction I.D. or a post-effective amendment thereto that shall become effective upon filing with the Commission pursuant to Rule 462(e) under the Securities Act, check the following box. ☐

If this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.D. filed to register additional securities or additional classes of securities pursuant to Rule 413(b) under the Securities Act, check the following box. ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

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| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☒ | Accelerated filer | ☐ |
| Non-accelerated filer | ☐ | Smaller reporting company | ☐ |
|  |  | Emerging growth company | ☐ |

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If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

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**DEREGISTRATION OF SECURITIES** 

These post-effective amendments (these "<u>Post-Effective Amendments</u>") filed by Avidity Biosciences, Inc., a Delaware corporation (the "<u>Registrant</u>"), relate to the following registration statements on Form S-3 (together, the "<u>Registration Statements</u>"):

• Registration Statement No. 333-277481 filed with the U.S. Securities
and Exchange Commission (the " <u>Commission</u> ") on [February 28, 2024](http://www.sec.gov/Archives/edgar/data/1599901/000162828024007683/avidity-resaleformsx3febru.htm) , which became effective automatically upon filing,
registering the potential offering and resale by a selling stockholder identified therein of up to of 5,075,304 shares of the Registrant's common stock, par value $0.0001 per share (" <u>Common Stock</u> ");

• Registration Statement No. 
333-278469 filed with the Commission on [April 2, 2024](http://www.sec.gov/Archives/edgar/data/1599901/000162828024014362/avidity-resalesx3.htm) , which became effective automatically upon filing, registering the potential offering and
resale by the selling stockholders identified therein of up to 24,255,624 shares of Common Stock, consisting of (i) 15,224,773 outstanding shares of Common Stock held by certain of the selling stockholders and (ii) 9,030,851 shares of Common Stock
issuable to certain of the selling stockholders upon exercise of certain outstanding pre-funded warrants held by such selling stockholders; and

• Registration Statement No. 
333-279264 filed with the Commission on [May 9, 2024](http://www.sec.gov/Archives/edgar/data/1599901/000162828024022255/avidity-shelfformsx3.htm) , which became effective automatically upon filing, registering the potential offering,
issuance and sale by the Registrant of an indeterminate amount of (i) Common Stock, (ii) preferred stock of the Company, par value $0.0001 per share, (iii) debt securities, (iv) warrants to purchase Common Stock, preferred stock
or debt securities, and/or (v) units consisting of some or all of the foregoing securities.

On February 27, 2026, pursuant to the Agreement and Plan of Merger, dated as of October 25, 2025 (the "<u>Merger Agreement</u>"), by and among the Registrant, Novartis AG, a company limited by shares (*Aktiengesellschaft*) incorporated under the laws of Switzerland ("<u>Parent</u>"), and Ajax Acquisition Sub, Inc., a Delaware corporation ("<u>Merger Sub</u>"), Merger Sub merged with and into the Registrant, with the Registrant continuing as the surviving corporation and becoming an indirect wholly-owned subsidiary of Parent.

As a result of the transactions contemplated by the Merger Agreement, the Registrant has terminated any and all offerings and sales of securities pursuant to the Registration Statements. In accordance with the undertakings made by the Registrant in the Registration Statements to remove from registration, by means of a post-effective amendment, any of the securities of the Registrant registered under the Registration Statements which remain unsold at the termination of the offering, the Registrant hereby terminates the effectiveness of the Registration Statements and removes from registration all of the securities that remain unsold under the Registration Statements as of the date hereof, if any.

The Registrant is filing these Post-Effective Amendments to withdraw and remove from registration all securities registered pursuant to the Registration Statements that remain unsold as of the date hereof. The Registration Statements are hereby amended, as appropriate, to reflect the deregistration of such securities. After giving effect to these Post-Effective Amendments, there will be no remaining securities registered by the Registrant pursuant to the Registration Statements.

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**SIGNATURE** 

Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and has duly caused these Post-Effective Amendments to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of East Hanover, State of New Jersey, on February 27, 2026.

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| | |
|:---|:---|
| AVIDITY BIOSCIENCES, INC. | AVIDITY BIOSCIENCES, INC. |
| By: | /s/ Jaime Huertas |
| Name: | Jaime Huertas |
| Title: | Secretary |

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Pursuant to Rule 478 under the Securities Act of 1933, as amended, no other person is required to sign these Post-Effective Amendments.