# EDGAR Filing Document

**Accession Number:** 0000836487
**File Stem:** 0001104659-25-086085
**Filing Date:** 2025-9
**Character Count:** 5240
**Document Hash:** 617a7d016a7d60dc21fab8915c627946
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-25-086085.hdr.sgml**: 20250902

**ACCESSION NUMBER**: 0001104659-25-086085

**CONFORMED SUBMISSION TYPE**: 497K

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20250902

**DATE AS OF CHANGE**: 20250902

**EFFECTIVENESS DATE**: 20250902

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** MORGAN STANLEY INSTITUTIONAL FUND INC
- **CENTRAL INDEX KEY:** 0000836487

**ORGANIZATION NAME:**
- **EIN:** 000000000
- **STATE OF INCORPORATION:** MD
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 497K
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 033-23166
- **FILM NUMBER:** 251283220

**BUSINESS ADDRESS:**
- **STREET 1:** 1585 BROADWAY
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10036
- **BUSINESS PHONE:** 800-548-7786

**MAIL ADDRESS:**
- **STREET 1:** 1585 BROADWAY
- **CITY:** NEW YORK
- **STATE:** NY
- **ZIP:** 10036

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** MORGAN STANLEY DEAN WITTER INSTITUTIONAL FUND INC
- **DATE OF NAME CHANGE:** 19990329

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** MORGAN STANLEY INSTITUTIONAL FUND INC
- **DATE OF NAME CHANGE:** 19920703

## Series and Classes Contracts Data

### International Resilience Portfolio (Series ID: S000076842)

| Class ID   | Class Name   | Ticker Symbol   |
|:---|:---|:---|
| C000236927 | Class I      | MSDKX           |
| C000236928 | Class C      | MSDEX           |
| C000236929 | Class R6     | MSCZX           |
| C000236930 | Class A      | MSDFX           |

**Summary Prospectus and <br>Prospectus Supplement**

**September 2, 2025**

Morgan Stanley Institutional Fund, Inc.

Supplement dated September 2, 2025 to the Morgan Stanley Institutional Fund, Inc. Summary Prospectuses and Prospectus dated April 30, 2025, as supplemented

**American Resilience Portfolio<br>Global Franchise Portfolio<br>International Equity Portfolio<br>International Resilience Portfolio<br>(the "Funds")**

Effective October 31, 2025 (the "Effective Date"), Isabelle Mast and Anton Kryachok will begin serving as portfolio managers of each Fund and Nic Sochovsky and Marcus Watson will no longer serve as portfolio managers of each Fund. William D. Lock, Bruno Paulson, Alex Gabriele and Richard Perrott will continue to serve as portfolio managers of each Fund.

Accordingly, on the Effective Date, the Summary Prospectuses and Prospectus will be amended as follows:

All references to Nic Sochovsky and Marcus Watson in the Summary Prospectuses and Prospectus will be deleted.

The following will be added to the table in the sections of each Summary Prospectus titled "Fund Management—Portfolio Managers" and the Prospectus titled "Fund Summary—American Resilience Portfolio—Fund Management—Portfolio Managers", "Fund Summary—Global Franchise Portfolio—Fund Management—Portfolio Managers", "Fund Summary—International Equity Portfolio—Fund Management—Portfolio Managers" and "Fund Summary—International Resilience Portfolio—Fund Management—Portfolio Managers":

---

| | | |
|:---|:---|:---|
| **Name** | **Title with Sub-Adviser** | **Date Began**<br> **Managing Fund** |
| Isabelle Mast | Executive Director of MSIM Limited | October 2025 |
| Anton Kryachok | Executive Director of MSIM Limited | October 2025 |

---

The section of the Prospectus titled "Fund Management—Portfolio Management—American Resilience Portfolio, Global Franchise Portfolio, Global Stars Portfolio, International Equity Portfolio and International Resilience Portfolio" will be deleted in its entirety and replaced with the following:

**American Resilience Portfolio, Global Franchise Portfolio, Global Stars Portfolio, International Equity Portfolio and International Resilience Portfolio**

The Fund is managed by members of the International Equity team, which consists of portfolio managers. Except for the Global Stars Portfolio, current members of the team jointly and primarily responsible for the day-to-day management of the Fund are Messrs. Lock, Paulson, Gabriele, Perrott and Kryachok and Ms. Mast. Mr. Gabriele and Mr. Perrott are responsible for the day-to-day management of the Global Stars Portfolio.

Mr. Lock has been associated with MSIM Limited in an investment management capacity since 1994. Mr. Paulson has been associated with MSIM Limited in an investment management capacity since 2009. Mr. Gabriele has been associated with MSIM Limited in an investment management capacity since 2012. Mr. Perrott has been associated with MSIM Limited in an investment management capacity since 2015. Mr. Kryachok has been associated with MSIM Limited in an investment management capacity since 2021. Ms. Mast has been associated with MSIM Limited in an investment management capacity since 2021.

Each member of the team has both global sector research responsibilities and makes investment management decisions for the Fund.

The Fund's SAI provides additional information about the portfolio managers' compensation structure, other accounts managed by the portfolio managers and the portfolio managers' ownership of securities in the Fund.

The composition of the team may change from time to time.

**Please retain this supplement for future reference.**

&nbsp;&nbsp;&nbsp;&nbsp;IFISUMPROPSPT 9/25

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