# EDGAR Filing Document

**Accession Number:** 0001788028
**File Stem:** 0001213900-25-107874
**Filing Date:** 2025-11
**Character Count:** 20138
**Document Hash:** e7f3fbee8b146201fac6898d83d6372e
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001213900-25-107874.hdr.sgml**: 20251110

**ACCESSION NUMBER**: 0001213900-25-107874

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 15

**CONFORMED PERIOD OF REPORT**: 20251110

**ITEM INFORMATION**: Results of Operations and Financial Condition

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20251110

**DATE AS OF CHANGE**: 20251110

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Jasper Therapeutics, Inc.
- **CENTRAL INDEX KEY:** 0001788028
- **STANDARD INDUSTRIAL CLASSIFICATION:** BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 842984849
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-39138
- **FILM NUMBER:** 251464449

**BUSINESS ADDRESS:**
- **STREET 1:** 2200 BRIDGE PKWY SUITE #102
- **CITY:** REDWOOD CITY
- **STATE:** CA
- **ZIP:** 94065
- **BUSINESS PHONE:** 6505491400

**MAIL ADDRESS:**
- **STREET 1:** 2200 BRIDGE PKWY SUITE #102
- **CITY:** REDWOOD CITY
- **STATE:** CA
- **ZIP:** 94065

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Amplitude Healthcare Acquisition Corp
- **DATE OF NAME CHANGE:** 20190912

?xml version='1.0' encoding='ASCII'?

**UNITED STATES SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**FORM 8-K**

**CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934**

**Date of Report (Date of earliest event reported): November 10, 2025**

**JASPER THERAPEUTICS, INC.**

**(Exact Name of Registrant as Specified in its Charter)**

---

| | | |
|:---|:---|:---|
| **Delaware** | **001-39138** | **84-2984849** |
| **(State or Other Jurisdiction<br> of Incorporation)** | **(Commission File Number)** | **(IRS Employer**<br> **Identification No.)** |

---

**2200 Bridge Pkwy Suite #102 Redwood City, California 94065**

**(Address of Principal Executive Offices) (Zip Code)**

**(650) 549-1400**

**Registrant's telephone number, including area code**

**N/A**

**(Former Name, or Former Address, if Changed Since Last Report)**

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Exchange Act:

---

| | | |
|:---|:---|:---|
| **(Title of each class)** | **(Trading Symbol)** | **(Name of exchange on which registered)** |
| **Voting Common Stock, par value $0.0001 per share** | **JSPR** | **The Nasdaq Stock Market LLC** |
| **Redeemable Warrants, each ten warrants exercisable for one share of Voting Common Stock at an exercise price of $115.00** | **JSPRW** | **The Nasdaq Stock Market LLC** |

---

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

**Item 2.02 Results of Operations and Financial Condition.** 

On November 10, 2025, Jasper Therapeutics, Inc. issued a press release reporting its financial results for the quarter ended September 30, 2025 and providing a corporate update. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K.

In accordance with General Instructions B.2 of Form 8-K, the information in this Item 2.02, including the press release attached hereto as Exhibit 99.1, is being furnished under Item 2.02 and Item 9.01 of Current Report on Form 8-K and shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liability of that section, and shall not be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such a filing.

**Item 9.01. Financial Statements and Exhibits.**

(d) Exhibits.

---

| | |
|:---|:---|
| **Exhibit No.** | **Description** |
| 99.1 | [Press Release, dated November 10, 2025.](ea026458601ex99-1_jasper.htm) |
| 104 | Cover Page Interactive Data File, formatted in Inline Extensible Business Reporting Language (iXBRL). |

---

**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

---

| | | | |
|:---|:---|:---|:---|
| Date: November 10, 2025 | **JASPER THERAPEUTICS, INC.** | **JASPER THERAPEUTICS, INC.** | **JASPER THERAPEUTICS, INC.** |
|  | By: | /s/ Herb Cross | /s/ Herb Cross |
|  |  | Name: | Herb Cross |
|  |  | Title: | Chief Financial Officer |

---

## Exhibit 99.1

**Exhibit 99.1**

![](ex99-1_001.jpg)

**Jasper Therapeutics Reports Third Quarter 2025 Financial Results and Provides Corporate Update**

**REDWOOD CITY, Calif., November 10, 2025 (GLOBE NEWSWIRE)** – Jasper Therapeutics, Inc. (Nasdaq: JSPR) (Jasper), a clinical stage biotechnology company focused on development of briquilimab, a novel antibody therapy targeting c-Kit (CD117) to address mast cell driven diseases such as chronic spontaneous urticaria (CSU), chronic inducible urticaria (CIndU) and asthma, today reported results for the fiscal quarter ended September 30, 2025 and provided a corporate update.

"With a number of data events expected in the coming months, we remain focused on advancing our programs in chronic urticaria and continue to believe that briquilimab has the potential to serve as a highly differentiated therapeutic in mast cell disease based on the results we've generated thus far," said Ronald Martell, President and Chief Executive Officer of Jasper. "Our investigation into anomalous efficacy results observed in the 240mg Q8W and the 240mg/180mg Q8W cohorts of the BEACON study is nearing completion, and we are encouraged by the determination that the results seen in these two cohorts do not appear to be related to any issues with drug substance or drug product. We plan to complete the investigation and report final conclusions in the fourth quarter of this year. We also plan to report initial data from the ETESIAN study in allergic asthma in the fourth quarter and now plan to report data from additional patients enrolled in the BEACON study, along with updated data from CSU and CIndU patients enrolled in the open-label extension study, in the first half of the first quarter of 2026."

**Highlights for Third Quarter 2025 and Recent Weeks**

● Provided
 an update on the ongoing investigation into the confounded efficacy results reported in July
 2025 from the 240mg Q8W and the 240mg followed by 180mg Q8W cohorts of the BEACON study in
 CSU. Based on the work conducted to date, Jasper believes the anomalous efficacy results
 in these two cohorts do not appear to be related to drug substance ("DS") or
 drug product ("DP") manufacturing or distribution processes. This conclusion
 reflects, among other factors:

&nbsp;&nbsp;&nbsp;&nbsp;o A
 comprehensive review of manufacturing and distribution records;

&nbsp;&nbsp;&nbsp;&nbsp;o Robust
 testing of multiple lots across the manufacturing and clinical supply chain;

&nbsp;&nbsp;&nbsp;&nbsp;o Independent,
 blinded testing of returned drug product samples from trial sites; and

&nbsp;&nbsp;&nbsp;&nbsp;o Review
 of stability samples from the lots used in the two cohorts compared against other lots.

With no evidence of DS or DP issues, the ongoing investigation is now focused on clinical site activity, including:

&nbsp;&nbsp;&nbsp;&nbsp;o Patient
 selection and enrollment processes;

&nbsp;&nbsp;&nbsp;&nbsp;o Investigational
 product handling and administration at the site level;

&nbsp;&nbsp;&nbsp;&nbsp;o Drug
 delivery methods (for example, injection site, needle and injection media); and

&nbsp;&nbsp;&nbsp;&nbsp;o Additional
 patient and site-level data review.

● Jasper
 plans to report final conclusions from the investigation in the fourth quarter of 2025, supported
 by a key opinion leader panel that will review findings and provide clinical and chemistry,
 manufacturing and controls recommendations for integration into the planned Phase 2b CSU
 study.

● Continued
 to enroll additional patients across the 240mg/180mg Q8W and 240mg Q8W cohorts of the BEACON
 study, and continued to enroll CSU and CIndU patients in the open-label extension (OLE) study
 as they rolled off the BEACON and SPOTLIGHT studies. Jasper expects that the additional data
 from these BEACON cohorts and from the OLE study, anticipated in the first half of the first
 quarter of 2026, should be adequate to complete dose selection for the planned Phase 2b CSU
 study, which is now expected to commence mid-2026.

● Successfully
 completed a $30 million underwritten offering of common stock and warrants, which extends
 Jasper's cash runway through the first half of 2026.

**Third Quarter Fiscal 2025 Financial Results**

● Cash
 and cash equivalents as of September 30, 2025, totaled $50.9 million.

● Research
 and development expense for the three months ended September 30, 2025, was $14.4 million.

● General
 and administrative expense for the three months ended September 30, 2025, was $4.8 million.

● Jasper
 reported a net loss of $18.7 million, or basic and diluted net loss per share attributable
 to common stockholders of $1.13 for the three months ended September 30, 2025.

**About Jasper**

Jasper is a clinical-stage biotechnology company focused on developing briquilimab as a therapeutic for chronic mast cell diseases. Briquilimab is a targeted aglycosylated monoclonal antibody that blocks stem cell factor from binding to the cell-surface receptor KIT, thereby inhibiting signaling through the receptor. This inhibition disrupts the critical survival signal, leading to the depletion of the mast cells via apoptosis which removes the underlying source of the inflammatory response in mast cell driven diseases such as chronic urticaria and asthma. Jasper is currently conducting clinical studies of briquilimab as a treatment in patients with CSU, CIndU, and asthma. Briquilimab has a demonstrated efficacy and safety profile in patients and healthy volunteers, with positive clinical outcomes in both CSU and CIndU. For more information, please visit us at www.jaspertx.com.

**Forward-Looking Statements**

Certain statements included in this press release that are not historical facts are forward-looking statements for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995. Forward-looking statements are sometimes accompanied by words such as "believe," "may," "will," "estimate," "continue," "anticipate," "intend," "expect," "should," "would," "plan," "predict," "potential," "seem," "seek," "future," "outlook" and similar expressions that predict or indicate future events or trends or that are not statements of historical matters. These forward-looking statements include, but are not limited to, statements regarding briquilimab's potential, including with respect to its potential in mast cell driven diseases such as CSU, CIndU and asthma and its potential to be a highly differentiated therapy in mast cell disease; Jasper's investigation into anomalous efficacy results observed in the 240mg Q8W and the 240mg/180mg Q8W cohorts of the BEACON study and timing for completing the investigation and reporting final conclusions; anticipated data events in the coming months, including the expected timing of reporting initial data from the ETESIAN study in allergic asthma and reporting data from additional patients enrolled in the BEACON study and updated data from CSU and CIndU patients enrolled in the open-label extension study; the belief that additional data from BEACON cohorts and the open-label extension should be adequate to complete dose selection for the planned Phase 2b CSU study; the expected timing for completing dose selection for the planned Phase 2b CSU study; and Jasper's cash runway. These statements are based on various assumptions, whether or not identified in this press release, and on the current expectations of Jasper and are not predictions of actual performance. These forward-looking statements are provided for illustrative purposes only and are not intended to serve as, and must not be relied on by an investor as, a guarantee, an assurance, a prediction or a definitive statement of fact or probability. Many actual events and circumstances are beyond the control of Jasper. These forward-looking statements are subject to a number of risks and uncertainties, including general economic, political and business conditions; the risk that the potential product candidates that Jasper develops may not progress through clinical development or receive required regulatory approvals within expected timelines or at all; the risk that clinical trials may not confirm any safety, potency or other product characteristics described or assumed in this press release; the risk that prior test, study and trial results may not be replicated in continuing or future studies and trials; the risk that Jasper's investigation into the confounded efficacy results from the 240mg Q8W and the 240mg followed by 180mg Q8W cohorts of the BEACON study in CSU may be inconclusive or may not lead to the anticipated conclusion; the risk that Jasper may be unable to raise capital to continue its operations and continue the BEACON study; the risk that Jasper will be unable to successfully market or gain market acceptance of its product candidates; the risk that prior study results may not be replicated; the risk that Jasper's product candidates may not be beneficial to patients or successfully commercialized; patients' willingness to try new therapies and the willingness of physicians to prescribe these therapies; the effects of competition on Jasper's business; the risk that third parties on which Jasper depends for laboratory, clinical development, manufacturing and other critical services will fail to perform satisfactorily; the risk that Jasper's business, operations, clinical development plans and timelines, and supply chain could be adversely affected by the effects of health epidemics; the risk that Jasper will be unable to obtain and maintain sufficient intellectual property protection for its investigational products or will infringe the intellectual property protection of others; and other risks and uncertainties indicated from time to time in Jasper's filings with the SEC, including its Annual Report on Form 10-K for the year ended December 31, 2024 and subsequent Quarterly Reports on Form 10-Q. If any of these risks materialize or Jasper's assumptions prove incorrect, actual results could differ materially from the results implied by these forward-looking statements. While Jasper may elect to update these forward-looking statements at some point in the future, Jasper specifically disclaims any obligation to do so. These forward-looking statements should not be relied upon as representing Jasper's assessments of any date subsequent to the date of this press release. Accordingly, undue reliance should not be placed upon the forward-looking statements.

**Contacts:**

Alex Gray (investors)

Jasper Therapeutics

650-549-1454

agray@jaspertx.com

Joyce Allaire (investors)

LifeSci Advisors

617-435-6602

jallaire@lifesciadvisors.com

Molly Devlin (media)

Real Chemistry

443-416-6675

mdevlin@realchemistry.com

**JASPER THERAPEUTICS, INC.**

**CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS**

***(in thousands, except share and per share data)***

***(unaudited)***

 ****

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **Three Months Ended<br> September 30,** | **Three Months Ended<br> September 30,** | **Nine Months Ended<br> September 30,** | **Nine Months Ended<br> September 30,** |
|  | **2025** | **2024** | **2025** | **2024** |
| Operating expenses |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Research and development<sup>(1)</sup> | $14391 | $14455 | $51744 | $36049 |
| &nbsp;&nbsp;&nbsp;General and administrative<sup>(1)</sup> | 4775 | 5434 | 16300 | 14905 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total operating expenses | 19166 | 19889 | 68044 | 50954 |
| Loss from operations | (19166) | (19889) | (68044) | (50954) |
| &nbsp;&nbsp;&nbsp;Interest income | 342 | 1284 | 1403 | 4120 |
| &nbsp;&nbsp;&nbsp;Change in fair value of warrants liability | 2099 |  | 2099 |  |
| &nbsp;&nbsp;&nbsp;Other expense, net | (2011) | (32) | (2158) | (114) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total other income, net | 430 | 1252 | 1344 | 4006 |
| Net loss and comprehensive loss | $(18736) | $(18637) | $(66700) | $(46948) |
| Net loss per share attributable to common stockholders, basic and diluted | $(1.13) | $(1.24) | $(4.18) | $(3.25) |
| Weighted-average shares used in computing net loss per share attributable to common stockholders, basic and diluted | 16635784 | 15000516 | 15968203 | 14442637 |

---

(1) Amounts include non-cash stock based compensation expense as
follows (in thousands):

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **Three Months Ended<br> September 30,** | **Three Months Ended<br> September 30,** | **Nine Months Ended<br> September 30,** | **Nine Months Ended<br> September 30,** |
|  | **2025** | **2024** | **2025** | **2024** |
| Research and development | $938 | $1420 | $3452 | $3249 |
| General and administrative | 486 | 578 | 1600 | 1400 |
| &nbsp;&nbsp;&nbsp;Total | $1424 | $1998 | $5052 | $4649 |

---

**JASPER THERAPEUTICS, INC.**

**CONDENSED CONSOLIDATED BALANCE SHEETS**

***(in thousands)***

***(unaudited)***

---

| | | |
|:---|:---|:---|
|  | **September 30,**<br>**2025** | **December 31,**<br>**2024** |
| **Assets** |  |  |
| Current assets: |  |  |
| &nbsp;&nbsp;&nbsp;Cash and cash equivalents | $50899 | $71637 |
| &nbsp;&nbsp;&nbsp;Prepaid expenses and other current assets | 3665 | 4174 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total current assets | 54564 | 75811 |
| Property and equipment, net | 1102 | 1875 |
| Operating lease right-of-use assets | 1236 | 976 |
| Restricted cash | 417 | 417 |
| Other non-current assets | 150 | 820 |
| Total assets | $57469 | $79899 |
| **Liabilities and Stockholders' Equity** |  |  |
| Current liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;Accounts payable | $9166 | $4027 |
| &nbsp;&nbsp;&nbsp;Current portion of operating lease liabilities | 1703 | 1089 |
| &nbsp;&nbsp;&nbsp;Accrued expenses and other current liabilities | 10172 | 10121 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total current liabilities | 21041 | 15237 |
| Non-current portion of operating lease liabilities |  | 724 |
| Warrant liability | 22593 |  |
| Other non-current liabilities | 2264 | 2264 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total liabilities | 45898 | 18225 |
| Commitments and contingencies |  |  |
| Stockholders' equity: |  |  |
| &nbsp;&nbsp;&nbsp;Preferred stock |  |  |
| &nbsp;&nbsp;&nbsp;Common stock | 3 | 2 |
| &nbsp;&nbsp;&nbsp;Additional paid-in capital | 319137 | 302541 |
| &nbsp;&nbsp;&nbsp;Accumulated deficit | (307569) | (240869) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total stockholders' equity | 11571 | 61674 |
| Total liabilities and stockholders' equity | $57469 | $79899 |

---