# EDGAR Filing Document

**Accession Number:** 0001100663
**File Stem:** 0002071691-25-007626
**Filing Date:** 2025-11
**Character Count:** 92105
**Document Hash:** 53dd25a232441eed2c821f5a21751964
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0002071691-25-007626.hdr.sgml**: 20251126

**ACCESSION NUMBER**: 0002071691-25-007626

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 1

**CONFORMED PERIOD OF REPORT**: 20250930

**FILED AS OF DATE**: 20251126

**DATE AS OF CHANGE**: 20251126

**PERIOD START**: 20260331

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** iSHARES TRUST
- **CENTRAL INDEX KEY:** 0001100663

**ORGANIZATION NAME:**
- **EIN:** 943351276
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-09729
- **FILM NUMBER:** 251526947

**BUSINESS ADDRESS:**
- **STREET 1:** 400 HOWARD STREET
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94105
- **BUSINESS PHONE:** (415) 670-2000

**MAIL ADDRESS:**
- **STREET 1:** 400 HOWARD STREET
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94105

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ISHARES TRUST
- **DATE OF NAME CHANGE:** 19991213

## Series and Classes Contracts Data

### iShares Biotechnology ETF (Series ID: S000004350)

| Class ID   | Class Name                | Ticker Symbol   |
|:---|:---|:---|
| C000012080 | iShares Biotechnology ETF | IBB             |

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** iShares Trust

- **b. Investment Company Act file number:** 811-09729

- **c. CIK number of Registrant:** 0001100663

- **d. LEI of Registrant:** 5493000860OXIC4B5K91

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 400 Howard Street

  - **City:** San Francisco

  - **State:** CA

  - **Foreign country:** US

  - **Zip / Postal Code:** 94105

  - **Telephone number:** 800-474-2737

**Item A.2. Information about the Series.**

- **a. Name of Series:** iShares Biotechnology ETF

- **b. EDGAR series identifier (if any):** S000004350

- **c. LEI of Series:** 549300S7IVD88MPK0066

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2026-03-31

- **b. Date as of which information is reported:** 2025-09-30

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $6727860288.26

**Total Liabilities:** $787078927.42

**Net Assets:** $5940781360.84

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000012080 | 4.91%                | 4.09%                | 4.52%                |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $10597024.23             | $249678803.15                              |
| Month 2  | $72125053.94             | $147346427.72                              |
| Month 3  | $-133736722.17           | $383503045.87                              |

**Designated Index Information**

- **Index Name:** N/A

- **Index Identifier:** N/A

### Schedule of Portfolio Investments

| Name                                           | Title                                                 | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)   | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Applied Therapeutics, Inc.                     | Applied Therapeutics, Inc.                            | CUSIP: 03828A101<br>LEI: 549300KL3IJPHZM2GR04 | Long             | EC               | CORP              | US        |    758868 | NS      | $459039.25    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| MannKind Corp.                                 | MannKind Corp.                                        | CUSIP: 56400P706<br>LEI: 213800GFBCNY1ZFST722 | Long             | EC               | CORP              | US        |   1756934 | NS      | $9434735.58   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurogene, Inc.                                | Neurogene, Inc.                                       | CUSIP: 64135M105<br>LEI: 529900A7VIY892SZVW73 | Long             | EC               | CORP              | US        |     72493 | NS      | $1256303.69   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Apogee Therapeutics, Inc.                      | Apogee Therapeutics, Inc.                             | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    217040 | NS      | $8622999.20   | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Enliven Therapeutics, Inc.                     | Enliven Therapeutics, Inc.                            | CUSIP: 29337E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    224914 | NS      | $4603989.58   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Bicycle Therapeutics plc                       | Bicycle Therapeutics plc                              | CUSIP: 088786108<br>LEI: 213800XKUI6R7GKC3E43 | Long             | EC               | CORP              | GB        |    183518 | NS      | $1420429.32   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Cargo Therapeutics, Inc.                       | Cargo Therapeutics, Inc., CVR                         | CUSIP: 141CVR019<br>LEI: N/A                  | Long             |  | CORP              | US        |    198104 | NS      | $1.98         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Ionis Pharmaceuticals, Inc.                    | Ionis Pharmaceuticals, Inc.                           | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |    932115 | NS      | $60978963.30  | 1.03%             |  |  |  | No            |                  1 | On Loan: No      |
| United Therapeutics Corp.                      | United Therapeutics Corp.                             | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |    257939 | NS      | $108130608.19 | 1.82%             |  |  |  | No            |                  1 | On Loan: No      |
| Solid Biosciences, Inc.                        | Solid Biosciences, Inc.                               | CUSIP: 83422E204<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    346017 | NS      | $2134924.89   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| uniQure NV                                     | uniQure NV                                            | CUSIP: N/A<br>LEI: 724500RPCTZLFYJZ3S98       | Long             | EC               | CORP              | NL        |    286743 | NS      | $16737188.91  | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| ORIC Pharmaceuticals, Inc.                     | ORIC Pharmaceuticals, Inc.                            | CUSIP: 68622P109<br>LEI: 54930033FJRNEYBW0L25 | Long             | EC               | CORP              | US        |    329549 | NS      | $3954588.00   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Tango Therapeutics, Inc.                       | Tango Therapeutics, Inc.                              | CUSIP: 87583X109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    384846 | NS      | $3232706.40   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Madrigal Pharmaceuticals, Inc.                 | Madrigal Pharmaceuticals, Inc.                        | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |    118887 | NS      | $54528711.42  | 0.92%             |  |  |  | No            |                  1 | On Loan: No      |
| 4D Molecular Therapeutics, Inc.                | 4D Molecular Therapeutics, Inc.                       | CUSIP: 35104E100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    254035 | NS      | $2207564.15   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Savara, Inc.                                   | Savara, Inc.                                          | CUSIP: 805111101<br>LEI: 5493002JO0WM3YMJXG33 | Long             | EC               | CORP              | US        |    478142 | NS      | $1706966.94   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Stoke Therapeutics, Inc.                       | Stoke Therapeutics, Inc.                              | CUSIP: 86150R107<br>LEI: 549300RD25SS2DIJHJ67 | Long             | EC               | CORP              | US        |    270779 | NS      | $6363306.50   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| BioMarin Pharmaceutical, Inc.                  | BioMarin Pharmaceutical, Inc.                         | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |   1115173 | NS      | $60397769.68  | 1.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Lexeo Therapeutics, Inc.                       | Lexeo Therapeutics, Inc.                              | CUSIP: 52886X107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    270456 | NS      | $1795827.84   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Cybin, Inc.                                    | Cybin, Inc.                                           | CUSIP: 23256X407<br>LEI: 549300NTYWN4CVYSCN32 | Long             | EC               | CORP              | CA        |    121852 | NS      | $717708.28    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Kymera Therapeutics, Inc.                      | Kymera Therapeutics, Inc.                             | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    347184 | NS      | $19650614.40  | 0.33%             |  |  |  | No            |                  1 | On Loan: No      |
| Alumis, Inc.                                   | Alumis, Inc.                                          | CUSIP: 022307102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    393866 | NS      | $1571525.34   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Merus NV                                       | Merus NV                                              | CUSIP: N/A<br>LEI: 549300W8GPUWU8QNU293       | Long             | EC               | CORP              | NL        |    402075 | NS      | $37855361.25  | 0.64%             |  |  |  | No            |                  1 | On Loan: No      |
| 89bio, Inc.                                    | 89bio, Inc.                                           | CUSIP: 282559103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    860093 | NS      | $12643367.10  | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Waters Corp.                                   | Waters Corp.                                          | CUSIP: 941848103<br>LEI: 5T547R1474YC9HOD8Q74 | Long             | EC               | CORP              | US        |    350226 | NS      | $105001257.06 | 1.77%             |  |  |  | No            |                  1 | On Loan: No      |
| Fusion Pharmaceuticals, Inc.                   | Fusion Pharmaceuticals, Inc., CVR                     | CUSIP: 361CVR012<br>LEI: N/A                  | Long             |  | CORP              | CA        |      1880 | NS      | $1034.00      | 0.00%             |  |  |  | No            |                  2 | On Loan: No      |
| Amylyx Pharmaceuticals, Inc.                   | Amylyx Pharmaceuticals, Inc.                          | CUSIP: 03237H101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    392232 | NS      | $5330432.88   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Mineralys Therapeutics, Inc.                   | Mineralys Therapeutics, Inc.                          | CUSIP: 603170101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    251197 | NS      | $9525390.24   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Medpace Holdings, Inc.                         | Medpace Holdings, Inc.                                | CUSIP: 58506Q109<br>LEI: 549300H8TYEUVTW14A54 | Long             | EC               | CORP              | US        |    133777 | NS      | $68782782.32  | 1.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Repligen Corp.                                 | Repligen Corp.                                        | CUSIP: 759916109<br>LEI: 54930006QJ0T5AUO1E71 | Long             | EC               | CORP              | US        |    313569 | NS      | $41914768.23  | 0.71%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences, Inc.                   | Neurocrine Biosciences, Inc.                          | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |    568938 | NS      | $79867516.44  | 1.34%             |  |  |  | No            |                  1 | On Loan: No      |
| MeiraGTx Holdings plc                          | MeiraGTx Holdings plc                                 | CUSIP: N/A<br>LEI: 54930007YV6NYIOGFZ57       | Long             | EC               | CORP              | KY        |    319325 | NS      | $2628044.75   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Absci Corp.                                    | Absci Corp.                                           | CUSIP: 00091E109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    770631 | NS      | $2342718.24   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Insmed, Inc.                                   | Insmed, Inc.                                          | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |   1218824 | NS      | $175522844.24 | 2.95%             |  |  |  | No            |                  1 | On Loan: No      |
| Dyne Therapeutics, Inc.                        | Dyne Therapeutics, Inc.                               | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    646430 | NS      | $8177339.50   | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Vera Therapeutics, Inc.                        | Vera Therapeutics, Inc., Class A                      | CUSIP: 92337R101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    286165 | NS      | $8315954.90   | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Rhythm Pharmaceuticals, Inc.                   | Rhythm Pharmaceuticals, Inc.                          | CUSIP: 76243J105<br>LEI: 529900JPNWXQ8DPLA551 | Long             | EC               | CORP              | US        |    362724 | NS      | $36631496.76  | 0.62%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen, Inc.                                   | Biogen, Inc.                                          | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |    862853 | NS      | $120868448.24 | 2.03%             |  |  |  | No            |                  1 | On Loan: No      |
| OmniAb, Inc.                                   | OmniAb, Inc., 15.00 Earnout Shares                    | CUSIP: 68218J301<br>LEI: N/A                  | Long             |  | CORP              | US        |     46839 | NS      | $0.47         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Design Therapeutics, Inc.                      | Design Therapeutics, Inc.                             | CUSIP: 25056L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    183659 | NS      | $1382952.27   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Kura Oncology, Inc.                            | Kura Oncology, Inc.                                   | CUSIP: 50127T109<br>LEI: 5493005QORQTZCZYOP39 | Long             | EC               | CORP              | US        |    496259 | NS      | $4391892.15   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Mettler-Toledo International, Inc.             | Mettler-Toledo International, Inc.                    | CUSIP: 592688105<br>LEI: 5493000BD5GJNUDIUG10 | Long             | EC               | CORP              | US        |    120598 | NS      | $148047310.78 | 2.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Tarsus Pharmaceuticals, Inc.                   | Tarsus Pharmaceuticals, Inc.                          | CUSIP: 87650L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    227401 | NS      | $13514441.43  | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Charles River Laboratories International, Inc. | Charles River Laboratories International, Inc.        | CUSIP: 159864107<br>LEI: 549300BSQ0R4UZ5KX287 | Long             | EC               | CORP              | US        |    286932 | NS      | $44893380.72  | 0.76%             |  |  |  | No            |                  1 | On Loan: No      |
| Nurix Therapeutics, Inc.                       | Nurix Therapeutics, Inc.                              | CUSIP: 67080M103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    441837 | NS      | $4082573.88   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Pliant Therapeutics, Inc.                      | Pliant Therapeutics, Inc.                             | CUSIP: 729139105<br>LEI: 5493002Q5LITR7VHZH02 | Long             | EC               | CORP              | US        |    331943 | NS      | $491275.64    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Phathom Pharmaceuticals, Inc.                  | Phathom Pharmaceuticals, Inc.                         | CUSIP: 71722W107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    224125 | NS      | $2637951.25   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Mersana Therapeutics, Inc.                     | Mersana Therapeutics, Inc.                            | CUSIP: 59045L205<br>LEI: 529900VWD5VDZ7PVOS22 | Long             | EC               | CORP              | US        |     24758 | NS      | $192122.08    | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Entrada Therapeutics, Inc.                     | Entrada Therapeutics, Inc.                            | CUSIP: 29384C108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    137206 | NS      | $795794.80    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Alpha Teknova, Inc.                            | Alpha Teknova, Inc.                                   | CUSIP: 02080L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     68099 | NS      | $421532.81    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Editas Medicine, Inc.                          | Editas Medicine, Inc.                                 | CUSIP: 28106W103<br>LEI: 5299000AON4Q9NT2JE42 | Long             | EC               | CORP              | US        |    511653 | NS      | $1775435.91   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Ironwood Pharmaceuticals, Inc.                 | Ironwood Pharmaceuticals, Inc., Class A               | CUSIP: 46333X108<br>LEI: 549300PC8MR6QHH6P296 | Long             | EC               | CORP              | US        |    921915 | NS      | $1207708.65   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Allogene Therapeutics, Inc.                    | Allogene Therapeutics, Inc.                           | CUSIP: 019770106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    913915 | NS      | $1133254.60   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Edgewise Therapeutics, Inc.                    | Edgewise Therapeutics, Inc.                           | CUSIP: 28036F105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    439588 | NS      | $7130117.36   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Argenx SE                                      | Argenx SE                                             | CUSIP: 04016X101<br>LEI: 7245009C5FZE6G9ODQ71 | Long             | EC               | CORP              | NL        |    253715 | NS      | $187130035.40 | 3.15%             |  |  |  | No            |                  1 | On Loan: No      |
| BlackRock Funds III                            | BlackRock Cash Funds: Institutional, SL Agency Shares | CUSIP: 066922519<br>LEI: 549300JDHS1T46VWOG19 | Long             | STIV             | RF                | US        | 782727603 | NS      | $783118966.80 | 13.18%            |  |  |  | No            |                  1 | On Loan: No      |
| Aura Biosciences, Inc.                         | Aura Biosciences, Inc.                                | CUSIP: 05153U107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    244938 | NS      | $1513716.84   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Genmab A/S                                     | Genmab A/S                                            | CUSIP: 372303206<br>LEI: 529900MTJPDPE4MHJ122 | Long             | EC               | CORP              | DK        |   2670531 | NS      | $81905185.77  | 1.38%             |  |  |  | No            |                  1 | On Loan: No      |
| Recursion Pharmaceuticals, Inc.                | Recursion Pharmaceuticals, Inc., Class A              | CUSIP: 75629V104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1963606 | NS      | $9582397.28   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Zai Lab Ltd.                                   | Zai Lab Ltd.                                          | CUSIP: 98887Q104<br>LEI: 549300P2UYQ9U5LY1T58 | Long             | EC               | CORP              | KY        |    455502 | NS      | $15436962.78  | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Olema Pharmaceuticals, Inc.                    | Olema Pharmaceuticals, Inc.                           | CUSIP: 68062P106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    311536 | NS      | $3049937.44   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Revolution Medicines, Inc.                     | Revolution Medicines, Inc.                            | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |    955294 | NS      | $44612229.80  | 0.75%             |  |  |  | No            |                  1 | On Loan: No      |
| Standard BioTools, Inc.                        | Standard BioTools, Inc.                               | CUSIP: 34385P108<br>LEI: 549300GX8Y96GSB6YP89 | Long             | EC               | CORP              | US        |   2155136 | NS      | $2801676.80   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| MacroGenics, Inc.                              | MacroGenics, Inc.                                     | CUSIP: 556099109<br>LEI: 5493001KJQUA83L8MH79 | Long             | EC               | CORP              | US        |    348613 | NS      | $585669.84    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| 10X Genomics, Inc.                             | 10X Genomics, Inc., Class A                           | CUSIP: 88025U109<br>LEI: 5493003Z6741WNLG7H43 | Long             | EC               | CORP              | US        |    651138 | NS      | $7611803.22   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Myriad Genetics, Inc.                          | Myriad Genetics, Inc.                                 | CUSIP: 62855J104<br>LEI: 52990044IHUOUMETT163 | Long             | EC               | CORP              | US        |    520932 | NS      | $3766338.36   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Disc Medicine, Inc.                            | Disc Medicine, Inc.                                   | CUSIP: 254604101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    135425 | NS      | $8948884.00   | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Bio-Techne Corp.                               | Bio-Techne Corp.                                      | CUSIP: 09073M104<br>LEI: 54930073RLKQ51TILZ35 | Long             | EC               | CORP              | US        |    906482 | NS      | $50427593.66  | 0.85%             |  |  |  | No            |                  1 | On Loan: No      |
| Theravance Biopharma, Inc.                     | Theravance Biopharma, Inc.                            | CUSIP: N/A<br>LEI: 5493007VTSXP4Z6MIW52       | Long             | EC               | CORP              | KY        |    272949 | NS      | $3985055.40   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| ADC Therapeutics SA                            | ADC Therapeutics SA                                   | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | CH        |    519910 | NS      | $2079640.00   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Tempus AI, Inc.                                | Tempus AI, Inc.                                       | CUSIP: 88023B103<br>LEI: 2549009LA0KWRAGQBX50 | Long             | EC               | CORP              | US        |    567192 | NS      | $45778066.32  | 0.77%             |  |  |  | No            |                  1 | On Loan: No      |
| Fortrea Holdings, Inc.                         | Fortrea Holdings, Inc.                                | CUSIP: 34965K107<br>LEI: 5493000FIVFABOVCDU97 | Long             | EC               | CORP              | US        |    532691 | NS      | $4485258.22   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| WaVe Life Sciences Ltd.                        | WaVe Life Sciences Ltd.                               | CUSIP: N/A<br>LEI: 54930070006GPKFYZ813       | Long             | EC               | CORP              | SG        |    749065 | NS      | $5483155.80   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Q32 Bio, Inc.                                  | Q32 Bio, Inc.                                         | CUSIP: 746964105<br>LEI: 549300RWKPJEFTM3K452 | Long             | EC               | CORP              | US        |     25036 | NS      | $49571.28     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Ideaya Biosciences, Inc.                       | Ideaya Biosciences, Inc.                              | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |    475477 | NS      | $12937729.17  | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytek Biosciences, Inc.                        | Cytek Biosciences, Inc.                               | CUSIP: 23285D109<br>LEI: 549300K2J28BOC6FBO89 | Long             | EC               | CORP              | US        |    681166 | NS      | $2363646.02   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Bruker Corp.                                   | Bruker Corp.                                          | CUSIP: 116794108<br>LEI: LEBZ6VLQ6I8XB1NHVY15 | Long             | EC               | CORP              | US        |    606933 | NS      | $19719253.17  | 0.33%             |  |  |  | No            |                  1 | On Loan: No      |
| Roivant Sciences Ltd.                          | Roivant Sciences Ltd.                                 | CUSIP: N/A<br>LEI: 549300DL466NY5J6U724       | Long             | EC               | CORP              | BM        |   2535527 | NS      | $38362523.51  | 0.65%             |  |  |  | No            |                  1 | On Loan: No      |
| Praxis Precision Medicines, Inc.               | Praxis Precision Medicines, Inc.                      | CUSIP: 74006W207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    116558 | NS      | $6177574.00   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Twist Bioscience Corp.                         | Twist Bioscience Corp.                                | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |    339583 | NS      | $9555865.62   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytokinetics, Inc.                             | Cytokinetics, Inc.                                    | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |    689949 | NS      | $37919597.04  | 0.64%             |  |  |  | No            |                  1 | On Loan: No      |
| Sutro Biopharma, Inc.                          | Sutro Biopharma, Inc.                                 | CUSIP: 869367102<br>LEI: 5493005U6P15VD25P851 | Long             | EC               | CORP              | US        |    483483 | NS      | $419856.64    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcturus Therapeutics Holdings, Inc.           | Arcturus Therapeutics Holdings, Inc.                  | CUSIP: 03969T109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    146596 | NS      | $2701764.28   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Illumina, Inc.                                 | Illumina, Inc.                                        | CUSIP: 452327109<br>LEI: SQ95QG8SR5Q56LSNF682 | Long             | EC               | CORP              | US        |    880979 | NS      | $83666575.63  | 1.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Exelixis, Inc.                                 | Exelixis, Inc.                                        | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |   1536779 | NS      | $63468972.70  | 1.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Quanterix Corp.                                | Quanterix Corp.                                       | CUSIP: 74766Q101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    231467 | NS      | $1256865.81   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Prothena Corp. plc                             | Prothena Corp. plc                                    | CUSIP: N/A<br>LEI: 5299009ZXQ8NIIJ8OL30       | Long             | EC               | CORP              | IE        |    262605 | NS      | $2563024.80   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Fate Therapeutics, Inc.                        | Fate Therapeutics, Inc.                               | CUSIP: 31189P102<br>LEI: 549300L14Q4UHOODLA90 | Long             | EC               | CORP              | US        |    654794 | NS      | $825040.44    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Day One Biopharmaceuticals, Inc.               | Day One Biopharmaceuticals, Inc.                      | CUSIP: 23954D109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    440087 | NS      | $3102613.35   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Galapagos NV                                   | Galapagos NV                                          | CUSIP: 36315X101<br>LEI: 549300QKJ78IY0IOV655 | Long             | EC               | CORP              | BE        |    204751 | NS      | $7092574.64   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Replimune Group, Inc.                          | Replimune Group, Inc.                                 | CUSIP: 76029N106<br>LEI: 549300AY704NEIRC4K64 | Long             | EC               | CORP              | US        |    377299 | NS      | $1580882.81   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Janux Therapeutics, Inc.                       | Janux Therapeutics, Inc.                              | CUSIP: 47103J105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    318965 | NS      | $7795504.60   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Centessa Pharmaceuticals plc                   | Centessa Pharmaceuticals plc                          | CUSIP: 152309100<br>LEI: 213800GIDAARDSKOI827 | Long             | EC               | CORP              | GB        |    354803 | NS      | $8603972.75   | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Novocure Ltd.                                  | Novocure Ltd.                                         | CUSIP: N/A<br>LEI: 213800YPP55UMHWA4826       | Long             | EC               | CORP              | JE        |    583622 | NS      | $7540396.24   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Fulgent Genetics, Inc.                         | Fulgent Genetics, Inc.                                | CUSIP: 359664109<br>LEI: 549300CL6P01M68QJ404 | Long             | EC               | CORP              | US        |    116346 | NS      | $2629419.60   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Castle Biosciences, Inc.                       | Castle Biosciences, Inc.                              | CUSIP: 14843C105<br>LEI: 2549007M2Q4HLR1XD252 | Long             | EC               | CORP              | US        |    166121 | NS      | $3782575.17   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Xenon Pharmaceuticals, Inc.                    | Xenon Pharmaceuticals, Inc.                           | CUSIP: 98420N105<br>LEI: 549300XV44Q9Z1MIPQ03 | Long             | EC               | CORP              | CA        |    436374 | NS      | $17520416.10  | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Enanta Pharmaceuticals, Inc.                   | Enanta Pharmaceuticals, Inc.                          | CUSIP: 29251M106<br>LEI: 529900SSN4DODDQSN594 | Long             | EC               | CORP              | US        |    115656 | NS      | $1384402.32   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Amicus Therapeutics, Inc.                      | Amicus Therapeutics, Inc.                             | CUSIP: 03152W109<br>LEI: 549300MRD1SMUTNBPQ53 | Long             | EC               | CORP              | US        |   1773032 | NS      | $13971492.16  | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Cullinan Therapeutics, Inc.                    | Cullinan Therapeutics, Inc.                           | CUSIP: 230031106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    219639 | NS      | $1302459.27   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Perspective Therapeutics, Inc.                 | Perspective Therapeutics, Inc.                        | CUSIP: 46489V302<br>LEI: 5493005LRKM6BCABC605 | Long             | EC               | CORP              | US        |    358167 | NS      | $1228512.81   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC Therapeutics, Inc.                         | PTC Therapeutics, Inc.                                | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |    448285 | NS      | $27511250.45  | 0.46%             |  |  |  | No            |                  1 | On Loan: No      |
| Ultragenyx Pharmaceutical, Inc.                | Ultragenyx Pharmaceutical, Inc.                       | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |    528536 | NS      | $15898362.88  | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvalent, Inc.                                 | Nuvalent, Inc., Class A                               | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    263343 | NS      | $22773902.64  | 0.38%             |  |  |  | No            |                  1 | On Loan: No      |
| Astria Therapeutics, Inc.                      | Astria Therapeutics, Inc.                             | CUSIP: 04635X102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    267005 | NS      | $1943796.40   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Codexis, Inc.                                  | Codexis, Inc.                                         | CUSIP: 192005106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    494911 | NS      | $1207582.84   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Natera, Inc.                                   | Natera, Inc.                                          | CUSIP: 632307104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    780157 | NS      | $125581872.29 | 2.11%             |  |  |  | No            |                  1 | On Loan: No      |
| ArriVent Biopharma, Inc.                       | ArriVent Biopharma, Inc.                              | CUSIP: 04272N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    175878 | NS      | $3244949.10   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| CareDx, Inc.                                   | CareDx, Inc.                                          | CUSIP: 14167L103<br>LEI: 549300NQOFKL9NON0U06 | Long             | EC               | CORP              | US        |    292667 | NS      | $4255378.18   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                            | Russell 2000 E-Mini Index                             | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |        33 | NC      | $24288.46     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| UroGen Pharma Ltd.                             | UroGen Pharma Ltd.                                    | CUSIP: N/A<br>LEI: 549300C0YCX7CG2G5D50       | Long             | EC               | CORP              | IL        |    233210 | NS      | $4652539.50   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Mirum Pharmaceuticals, Inc.                    | Mirum Pharmaceuticals, Inc.                           | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |    239639 | NS      | $17567935.09  | 0.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Kyverna Therapeutics, Inc.                     | Kyverna Therapeutics, Inc.                            | CUSIP: 501976104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    128772 | NS      | $772632.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| OPKO Health, Inc.                              | OPKO Health, Inc.                                     | CUSIP: 68375N103<br>LEI: 529900A4S2D4OGOJLL02 | Long             | EC               | CORP              | US        |   2112385 | NS      | $3274196.75   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Pacific Biosciences of California, Inc.        | Pacific Biosciences of California, Inc.               | CUSIP: 69404D108<br>LEI: 529900F1BWRE1M0KZN89 | Long             | EC               | CORP              | US        |   1559111 | NS      | $1995662.08   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| MaxCyte, Inc.                                  | MaxCyte, Inc.                                         | CUSIP: 57777K106<br>LEI: 54930053YHXULRFCU991 | Long             | EC               | CORP              | US        |    598801 | NS      | $946105.58    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Xencor, Inc.                                   | Xencor, Inc.                                          | CUSIP: 98401F105<br>LEI: 549300V5IF65437JKG30 | Long             | EC               | CORP              | US        |    395016 | NS      | $4633537.68   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Sarepta Therapeutics, Inc.                     | Sarepta Therapeutics, Inc.                            | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |    547865 | NS      | $10557358.55  | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcutis Biotherapeutics, Inc.                  | Arcutis Biotherapeutics, Inc.                         | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    616188 | NS      | $11615143.80  | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Summit Therapeutics, Inc.                      | Summit Therapeutics, Inc.                             | CUSIP: 86627T108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    661252 | NS      | $13661466.32  | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Corvus Pharmaceuticals, Inc.                   | Corvus Pharmaceuticals, Inc.                          | CUSIP: 221015100<br>LEI: 549300I3AVJ8F75NCX65 | Long             | EC               | CORP              | US        |    326202 | NS      | $2404108.74   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvation Bio, Inc.                             | Nuvation Bio, Inc., Class A                           | CUSIP: 67080N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1357425 | NS      | $5022472.50   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Atea Pharmaceuticals, Inc.                     | Atea Pharmaceuticals, Inc.                            | CUSIP: 04683R106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    379136 | NS      | $1099494.40   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| CG oncology, Inc.                              | CG oncology, Inc.                                     | CUSIP: 156944100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    276558 | NS      | $11139756.24  | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Iovance Biotherapeutics, Inc.                  | Iovance Biotherapeutics, Inc.                         | CUSIP: 462260100<br>LEI: 2549002L8WT2ACU5Q878 | Long             | EC               | CORP              | US        |   1726283 | NS      | $3746034.11   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Biomea Fusion, Inc.                            | Biomea Fusion, Inc.                                   | CUSIP: 09077A106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    306014 | NS      | $618148.28    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Annexon, Inc.                                  | Annexon, Inc.                                         | CUSIP: 03589W102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    561065 | NS      | $1711248.25   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Syndax Pharmaceuticals, Inc.                   | Syndax Pharmaceuticals, Inc.                          | CUSIP: 87164F105<br>LEI: 529900OF94TRHKZVBS87 | Long             | EC               | CORP              | US        |    491468 | NS      | $7561235.18   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Alnylam Pharmaceuticals, Inc.                  | Alnylam Pharmaceuticals, Inc.                         | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |    740112 | NS      | $337491072.00 | 5.68%             |  |  |  | No            |                  1 | On Loan: No      |
| Inhibrx Biosciences, Inc.                      | Inhibrx Biosciences, Inc.                             | CUSIP: 45720N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     58157 | NS      | $1958727.76   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Vaxcyte, Inc.                                  | Vaxcyte, Inc.                                         | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |    739720 | NS      | $26644714.40  | 0.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Keros Therapeutics, Inc.                       | Keros Therapeutics, Inc.                              | CUSIP: 492327101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    199903 | NS      | $3162465.46   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Ascendis Pharma A/S                            | Ascendis Pharma A/S                                   | CUSIP: 04351P101<br>LEI: 549300B66JN3W3J8GH73 | Long             | EC               | CORP              | DK        |    251979 | NS      | $50095944.99  | 0.84%             |  |  |  | No            |                  1 | On Loan: No      |
| Novavax, Inc.                                  | Novavax, Inc.                                         | CUSIP: 670002401<br>LEI: 529900J4GJHPEPQ23205 | Long             | EC               | CORP              | US        |    872435 | NS      | $7564011.45   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Beam Therapeutics, Inc.                        | Beam Therapeutics, Inc.                               | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    538089 | NS      | $13059420.03  | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Oruka Therapeutics, Inc.                       | Oruka Therapeutics, Inc.                              | CUSIP: 687604108<br>LEI: 529900TG7O4ESUDMGI54 | Long             | EC               | CORP              | US        |    180939 | NS      | $3479456.97   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Taysha Gene Therapies, Inc.                    | Taysha Gene Therapies, Inc.                           | CUSIP: 877619106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1306896 | NS      | $4273549.92   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Agios Pharmaceuticals, Inc.                    | Agios Pharmaceuticals, Inc.                           | CUSIP: 00847X104<br>LEI: 529900ONJHY8EOGYT555 | Long             | EC               | CORP              | US        |    320674 | NS      | $12871854.36  | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Ginkgo Bioworks Holdings, Inc.                 | Ginkgo Bioworks Holdings, Inc.                        | CUSIP: 37611X209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    238879 | NS      | $3482855.82   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Verona Pharma plc                              | Verona Pharma plc                                     | CUSIP: 925050106<br>LEI: 213800EVI6O6J3TIAL06 | Long             | EC               | CORP              | GB        |    326745 | NS      | $34866958.95  | 0.59%             |  |  |  | No            |                  1 | On Loan: No      |
| Axsome Therapeutics, Inc.                      | Axsome Therapeutics, Inc.                             | CUSIP: 05464T104<br>LEI: 549300EXGR0XLRJEIB95 | Long             | EC               | CORP              | US        |    242687 | NS      | $29474336.15  | 0.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Humacyte, Inc.                                 | Humacyte, Inc.                                        | CUSIP: 44486Q103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    768835 | NS      | $1337772.90   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| ADMA Biologics, Inc.                           | ADMA Biologics, Inc.                                  | CUSIP: 000899104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |   1358764 | NS      | $19919480.24  | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Alvotech SA                                    | Alvotech SA                                           | CUSIP: N/A<br>LEI: 222100DCZBOWV5DZ8372       | Long             | EC               | CORP              | LU        |    642482 | NS      | $5261927.58   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Newamsterdam Pharma Co. NV                     | Newamsterdam Pharma Co. NV                            | CUSIP: N/A<br>LEI: 984500B6549TF6E14D36       | Long             | EC               | CORP              | NL        |    431299 | NS      | $12266143.56  | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Crinetics Pharmaceuticals, Inc.                | Crinetics Pharmaceuticals, Inc.                       | CUSIP: 22663K107<br>LEI: 549300Q1CNFXK5P31D28 | Long             | EC               | CORP              | US        |    513572 | NS      | $21390273.80  | 0.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Alector, Inc.                                  | Alector, Inc.                                         | CUSIP: 014442107<br>LEI: 549300Z8RQOIY1JMHC25 | Long             | EC               | CORP              | US        |    459305 | NS      | $1359542.80   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| AnaptysBio, Inc.                               | AnaptysBio, Inc.                                      | CUSIP: 032724106<br>LEI: 529900HH4WQT03IG1A12 | Long             | EC               | CORP              | US        |    150888 | NS      | $4620190.56   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcus Biosciences, Inc.                        | Arcus Biosciences, Inc.                               | CUSIP: 03969F109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    385799 | NS      | $5246866.40   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Arvinas, Inc.                                  | Arvinas, Inc.                                         | CUSIP: 04335A105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    378922 | NS      | $3228415.44   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Geron Corp.                                    | Geron Corp.                                           | CUSIP: 374163103<br>LEI: 549300T282D7Z2YESL90 | Long             | EC               | CORP              | US        |   3563450 | NS      | $4881926.50   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Vanda Pharmaceuticals, Inc.                    | Vanda Pharmaceuticals, Inc.                           | CUSIP: 921659108<br>LEI: 529900AY8VOOQBKJ0O70 | Long             | EC               | CORP              | US        |    324410 | NS      | $1618805.90   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Autolus Therapeutics plc                       | Autolus Therapeutics plc                              | CUSIP: 05280R100<br>LEI: 549300C0KZP8EYROLL02 | Long             | EC               | CORP              | GB        |   1000395 | NS      | $1630643.85   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| ACADIA Pharmaceuticals, Inc.                   | ACADIA Pharmaceuticals, Inc.                          | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |    986966 | NS      | $21061854.44  | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals, Inc.                   | Vertex Pharmaceuticals, Inc.                          | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |   1162635 | NS      | $455334371.40 | 7.66%             |  |  |  | No            |                  1 | On Loan: No      |
| Cogent Biosciences, Inc.                       | Cogent Biosciences, Inc.                              | CUSIP: 19240Q201<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    663662 | NS      | $9530186.32   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| ARS Pharmaceuticals, Inc.                      | ARS Pharmaceuticals, Inc.                             | CUSIP: 82835W108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    339373 | NS      | $3410698.65   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| REGENXBIO, Inc.                                | REGENXBIO, Inc.                                       | CUSIP: 75901B107<br>LEI: 549300EOES47LATSET33 | Long             | EC               | CORP              | US        |    269917 | NS      | $2604699.05   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| BioCryst Pharmaceuticals, Inc.                 | BioCryst Pharmaceuticals, Inc.                        | CUSIP: 09058V103<br>LEI: 549300Z0INP1Z5NP6J59 | Long             | EC               | CORP              | US        |   1195186 | NS      | $9071461.74   | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| LENZ Therapeutics, Inc.                        | LENZ Therapeutics, Inc.                               | CUSIP: 52635N103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    141751 | NS      | $6602761.58   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Tevogen Bio Holdings, Inc.                     | Tevogen Bio Holdings, Inc.                            | CUSIP: 88165K101<br>LEI: 549300AC21G4NBK9D322 | Long             | EC               | CORP              | US        |    260788 | NS      | $204796.82    | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Rapport Therapeutics, Inc.                     | Rapport Therapeutics, Inc.                            | CUSIP: 75383L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    102967 | NS      | $3058119.90   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Climb Bio, Inc.                                | Climb Bio, Inc.                                       | CUSIP: 28658R106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    366108 | NS      | $735877.08    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Legend Biotech Corp.                           | Legend Biotech Corp.                                  | CUSIP: 52490G102<br>LEI: 254900EIUFZTW136H859 | Long             | EC               | CORP              | KY        |    752421 | NS      | $24536448.81  | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Arrowhead Pharmaceuticals, Inc.                | Arrowhead Pharmaceuticals, Inc.                       | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |    756770 | NS      | $26100997.30  | 0.44%             |  |  |  | No            |                  1 | On Loan: No      |
| Stevanato Group SpA                            | Stevanato Group SpA                                   | CUSIP: N/A<br>LEI: 81560033F7E1CD477507       | Long             | EC               | CORP              | IT        |    292466 | NS      | $7530999.50   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Avidity Biosciences, Inc.                      | Avidity Biosciences, Inc.                             | CUSIP: 05370A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    683841 | NS      | $29794952.37  | 0.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Tourmaline Bio, Inc.                           | Tourmaline Bio, Inc.                                  | CUSIP: 89157D105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     98115 | NS      | $4692840.45   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Zymeworks, Inc.                                | Zymeworks, Inc.                                       | CUSIP: 98985Y108<br>LEI: 894500AHOYAGYLYZJL67 | Long             | EC               | CORP              | US        |    430163 | NS      | $7347184.04   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Contra Chinook Therape                         | Contra Chinook Therape, CVR                           | CUSIP: 169CVR016<br>LEI: N/A                  | Long             |  | CORP              | US        |    320962 | NS      | $54563.54     | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Artiva Biotherapeutics, Inc.                   | Artiva Biotherapeutics, Inc.                          | CUSIP: 04317A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     68196 | NS      | $195722.52    | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Immunovant, Inc.                               | Immunovant, Inc.                                      | CUSIP: 45258J102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    416259 | NS      | $6710095.08   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| GRAIL, Inc.                                    | GRAIL, Inc.                                           | CUSIP: 384747101<br>LEI: 2549009XSNESW3VE8024 | Long             | EC               | CORP              | US        |    176141 | NS      | $10415217.33  | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Silence Therapeutics plc                       | Silence Therapeutics plc                              | CUSIP: 82686Q101<br>LEI: 213800SSURRJBX85SQ91 | Long             | EC               | CORP              | GB        |     32537 | NS      | $168867.03    | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Vir Biotechnology, Inc.                        | Vir Biotechnology, Inc.                               | CUSIP: 92764N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    528257 | NS      | $3016347.47   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Prime Medicine, Inc.                           | Prime Medicine, Inc.                                  | CUSIP: 74168J101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    556689 | NS      | $3084057.06   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Third Harmonic Bio, Inc.                       | Third Harmonic Bio, Inc.                              | CUSIP: 88427A107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    134478 | NS      | $4034.34      | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Akero Therapeutics, Inc.                       | Akero Therapeutics, Inc.                              | CUSIP: 00973Y108<br>LEI: 549300SI3KG74LBE2955 | Long             | EC               | CORP              | US        |    416668 | NS      | $19783396.64  | 0.33%             |  |  |  | No            |                  1 | On Loan: No      |
| Maravai LifeSciences Holdings, Inc.            | Maravai LifeSciences Holdings, Inc., Class A          | CUSIP: 56600D107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    609479 | NS      | $1749204.73   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Intellia Therapeutics, Inc.                    | Intellia Therapeutics, Inc.                           | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |    595924 | NS      | $10291607.48  | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Mesoblast Ltd.                                 | Mesoblast Ltd.                                        | CUSIP: 590717401<br>LEI: 529900J5ALF3JG921927 | Long             | EC               | CORP              | AU        |    385063 | NS      | $6203364.93   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Precigen, Inc.                                 | Precigen, Inc.                                        | CUSIP: 74017N105<br>LEI: 549300XCWNQU35K64G19 | Long             | EC               | CORP              | US        |    870291 | NS      | $2863257.39   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Aurinia Pharmaceuticals, Inc.                  | Aurinia Pharmaceuticals, Inc.                         | CUSIP: 05156V102<br>LEI: 5299008YP2BW4570ML28 | Long             | EC               | CORP              | CA        |    700358 | NS      | $7738955.90   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Scholar Rock Holding Corp.                     | Scholar Rock Holding Corp.                            | CUSIP: 80706P103<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |    436920 | NS      | $16270900.80  | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| Altimmune, Inc.                                | Altimmune, Inc.                                       | CUSIP: 02155H200<br>LEI: 549300EOYCQ8SW3NVE64 | Long             | EC               | CORP              | US        |    503452 | NS      | $1898014.04   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| IQVIA Holdings, Inc.                           | IQVIA Holdings, Inc.                                  | CUSIP: 46266C105<br>LEI: 549300W3R20NM4KQPH86 | Long             | EC               | CORP              | US        |    993636 | NS      | $188731221.84 | 3.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Rigel Pharmaceuticals, Inc.                    | Rigel Pharmaceuticals, Inc.                           | CUSIP: 766559702<br>LEI: 529900KPTNUS5J8K9K66 | Long             | EC               | CORP              | US        |    102908 | NS      | $2915383.64   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Protagonist Therapeutics, Inc.                 | Protagonist Therapeutics, Inc.                        | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    346590 | NS      | $23023973.70  | 0.39%             |  |  |  | No            |                  1 | On Loan: No      |
| ImmunityBio, Inc.                              | ImmunityBio, Inc.                                     | CUSIP: 45256X103<br>LEI: 529900J9XLBR4HFL4B83 | Long             | EC               | CORP              | US        |    561411 | NS      | $1381071.06   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Travere Therapeutics, Inc.                     | Travere Therapeutics, Inc.                            | CUSIP: 89422G107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    511607 | NS      | $12227407.30  | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| TScan Therapeutics, Inc.                       | TScan Therapeutics, Inc.                              | CUSIP: 89854M101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    271718 | NS      | $494526.76    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Bridgebio Pharma, Inc.                         | Bridgebio Pharma, Inc.                                | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |    956141 | NS      | $49661963.54  | 0.84%             |  |  |  | No            |                  1 | On Loan: No      |
| BeOne Medicines Ltd.                           | BeOne Medicines Ltd.                                  | CUSIP: 07725L102<br>LEI: 549300JFUK6FRD5MH739 | Long             | EC               | CORP              | CH        |    367410 | NS      | $125176587.00 | 2.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Cartesian Therapeutics, Inc.                   | Cartesian Therapeutics, Inc.                          | CUSIP: 816212112<br>LEI: 529900NMN0LACZOL7C43 | Long             |  | CORP              | US        |      6098 | NS      | $1524.50      | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Adaptive Biotechnologies Corp.                 | Adaptive Biotechnologies Corp.                        | CUSIP: 00650F109<br>LEI: 549300ZTF7OT1FW66Q96 | Long             | EC               | CORP              | US        |    856447 | NS      | $12812447.12  | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Rocket Pharmaceuticals, Inc.                   | Rocket Pharmaceuticals, Inc.                          | CUSIP: 77313F106<br>LEI: 549300R7VV82YUIN4Y93 | Long             | EC               | CORP              | US        |    583003 | NS      | $1900589.78   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Larimar Therapeutics, Inc.                     | Larimar Therapeutics, Inc.                            | CUSIP: 517125100<br>LEI: 529900NCBZHTTJV6HX73 | Long             | EC               | CORP              | US        |    286663 | NS      | $925921.49    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcellx, Inc.                                  | Arcellx, Inc.                                         | CUSIP: 03940C100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    243871 | NS      | $20021809.10  | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Amgen, Inc.                                    | Amgen, Inc.                                           | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |   1579688 | NS      | $445787953.60 | 7.50%             |  |  |  | No            |                  1 | On Loan: No      |
| C4 Therapeutics, Inc.                          | C4 Therapeutics, Inc.                                 | CUSIP: 12529R107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    353777 | NS      | $785384.94    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Halozyme Therapeutics, Inc.                    | Halozyme Therapeutics, Inc.                           | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |    681965 | NS      | $50015313.10  | 0.84%             |  |  |  | No            |                  1 | On Loan: No      |
| CorMedix, Inc.                                 | CorMedix, Inc.                                        | CUSIP: 21900C308<br>LEI: 5299006YIA3L0MBW8358 | Long             | EC               | CORP              | US        |    394365 | NS      | $4586464.95   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                            | E-Mini Health Care Select Sector Index                | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | US        |        42 | NC      | $31611.82     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Evotec SE                                      | Evotec SE                                             | CUSIP: 30050E105<br>LEI: 529900F9KI6OYITO9B12 | Long             | EC               | CORP              | DE        |   1303894 | NS      | $4733135.22   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Spyre Therapeutics, Inc.                       | Spyre Therapeutics, Inc.                              | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |    301385 | NS      | $5051212.60   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| KalVista Pharmaceuticals, Inc.                 | KalVista Pharmaceuticals, Inc.                        | CUSIP: 483497103<br>LEI: 529900Q7IDA3WUGRZA51 | Long             | EC               | CORP              | US        |    220824 | NS      | $2689636.32   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Krystal Biotech, Inc.                          | Krystal Biotech, Inc.                                 | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |    146589 | NS      | $25877356.17  | 0.44%             |  |  |  | No            |                  1 | On Loan: No      |
| Lyell Immunopharma, Inc.                       | Lyell Immunopharma, Inc.                              | CUSIP: 55083R203<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     50790 | NS      | $824829.60    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| BlackRock Funds III                            | BlackRock Cash Funds: Treasury, SL Agency Shares      | CUSIP: 066922477<br>LEI: 5493005PQV5UQG4OSI49 | Long             | STIV             | RF                | US        |  11130182 | NS      | $11130182.45  | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Monte Rosa Therapeutics, Inc.                  | Monte Rosa Therapeutics, Inc.                         | CUSIP: 61225M102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    272062 | NS      | $2015979.42   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Personalis, Inc.                               | Personalis, Inc.                                      | CUSIP: 71535D106<br>LEI: 549300EZ2NYFK7H0US48 | Long             | EC               | CORP              | US        |    312190 | NS      | $2035478.80   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Relay Therapeutics, Inc.                       | Relay Therapeutics, Inc.                              | CUSIP: 75943R102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    767379 | NS      | $4005718.38   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Regeneron Pharmaceuticals, Inc.                | Regeneron Pharmaceuticals, Inc.                       | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |    602167 | NS      | $338580439.09 | 5.70%             |  |  |  | No            |                  1 | On Loan: No      |
| Cartesian Therapeutics, Inc.                   | Cartesian Therapeutics, Inc.                          | CUSIP: 816212302<br>LEI: 529900NMN0LACZOL7C43 | Long             | EC               | CORP              | US        |     50587 | NS      | $516999.14    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Tectonic Therapeutic, Inc.                     | Tectonic Therapeutic, Inc.                            | CUSIP: 878972108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     61520 | NS      | $965248.80    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| CRISPR Therapeutics AG                         | CRISPR Therapeutics AG                                | CUSIP: N/A<br>LEI: 506700O6IRRIQLT3W370       | Long             | EC               | CORP              | CH        |    507714 | NS      | $32904944.34  | 0.55%             |  |  |  | No            |                  1 | On Loan: No      |
| Pyxis Oncology, Inc.                           | Pyxis Oncology, Inc.                                  | CUSIP: 747324101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    255304 | NS      | $566774.88    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Gilead Sciences, Inc.                          | Gilead Sciences, Inc.                                 | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |   4022925 | NS      | $446544675.00 | 7.52%             |  |  |  | No            |                  1 | On Loan: No      |
| Sana Biotechnology, Inc.                       | Sana Biotechnology, Inc.                              | CUSIP: 799566104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    852521 | NS      | $3026449.55   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| PepGen, Inc.                                   | PepGen, Inc.                                          | CUSIP: 713317105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    177329 | NS      | $819259.98    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Apellis Pharmaceuticals, Inc.                  | Apellis Pharmaceuticals, Inc.                         | CUSIP: 03753U106<br>LEI: 254900HS0ZFRXXSB9D42 | Long             | EC               | CORP              | US        |    614869 | NS      | $13914485.47  | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Incyte Corp.                                   | Incyte Corp.                                          | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |   1137628 | NS      | $96482230.68  | 1.62%             |  |  |  | No            |                  1 | On Loan: No      |
| Structure Therapeutics, Inc.                   | Structure Therapeutics, Inc.                          | CUSIP: 86366E106<br>LEI: N/A                  | Long             | EC               | CORP              | KY        |    235368 | NS      | $6590304.00   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Grifols SA                                     | Grifols SA                                            | CUSIP: 398438408<br>LEI: 959800HSSNXWRKBK4N60 | Long             | EC               | CORP              | ES        |    715410 | NS      | $7125483.60   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Denali Therapeutics, Inc.                      | Denali Therapeutics, Inc.                             | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |    745874 | NS      | $10830090.48  | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| AC Immune SA                                   | AC Immune SA                                          | CUSIP: N/A<br>LEI: 967600VLQ0ZC2HSOG765       | Long             | EC               | CORP              | CH        |    359213 | NS      | $1038125.57   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Biohaven Ltd.                                  | Biohaven Ltd.                                         | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | VG        |    544723 | NS      | $8176292.23   | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| AbCellera Biologics, Inc.                      | AbCellera Biologics, Inc.                             | CUSIP: 00288U106<br>LEI: 9845000861BC95FF9F73 | Long             | EC               | CORP              | CA        |   1329170 | NS      | $6685725.10   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Immunocore Holdings plc                        | Immunocore Holdings plc                               | CUSIP: 45258D105<br>LEI: 213800IUE3DFS84BVN18 | Long             | EC               | CORP              | GB        |    208143 | NS      | $7561835.19   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| CureVac NV                                     | CureVac NV                                            | CUSIP: N/A<br>LEI: 724500BUT8GAG9LMYN56       | Long             | EC               | CORP              | NL        |    563088 | NS      | $3035044.32   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| OnKure Therapeutics, Inc.                      | OnKure Therapeutics, Inc.                             | CUSIP: 68277Q105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     53057 | NS      | $145906.75    | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| BioNTech SE                                    | BioNTech SE                                           | CUSIP: 09075V102<br>LEI: 894500UZJ5LG1F8J1U58 | Long             | EC               | CORP              | DE        |    371903 | NS      | $36677073.86  | 0.62%             |  |  |  | No            |                  1 | On Loan: No      |
| Zevra Therapeutics, Inc.                       | Zevra Therapeutics, Inc.                              | CUSIP: 488445206<br>LEI: 254900CU6T74V18Y1W18 | Long             | EC               | CORP              | US        |    327165 | NS      | $3111339.15   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Foghorn Therapeutics, Inc.                     | Foghorn Therapeutics, Inc.                            | CUSIP: 344174107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    176297 | NS      | $862092.33    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Arbutus Biopharma Corp.                        | Arbutus Biopharma Corp.                               | CUSIP: 03879J100<br>LEI: 25490064CESONAUIAS23 | Long             | EC               | CORP              | CA        |    877309 | NS      | $3982982.86   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Vericel Corp.                                  | Vericel Corp.                                         | CUSIP: 92346J108<br>LEI: 54930076YM3PLTDR4B91 | Long             | EC               | CORP              | US        |    294316 | NS      | $9262124.52   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Trevi Therapeutics, Inc.                       | Trevi Therapeutics, Inc.                              | CUSIP: 89532M101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    476201 | NS      | $4357239.15   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Nkarta, Inc.                                   | Nkarta, Inc.                                          | CUSIP: 65487U108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    318966 | NS      | $660259.62    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Voyager Therapeutics, Inc.                     | Voyager Therapeutics, Inc.                            | CUSIP: 92915B106<br>LEI: 54930082S4XVR0ZWCC74 | Long             | EC               | CORP              | US        |    264056 | NS      | $1233141.52   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Acrivon Therapeutics, Inc.                     | Acrivon Therapeutics, Inc.                            | CUSIP: 004890109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    130270 | NS      | $235788.70    | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Erasca, Inc.                                   | Erasca, Inc.                                          | CUSIP: 29479A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    948726 | NS      | $2068222.68   | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Emergent BioSolutions, Inc.                    | Emergent BioSolutions, Inc.                           | CUSIP: 29089Q105<br>LEI: 549300YW6TUOX8BE5103 | Long             | EC               | CORP              | US        |    300990 | NS      | $2654731.80   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Immutep Ltd.                                   | Immutep Ltd.                                          | CUSIP: 45257L108<br>LEI: 529900OL6C5CY5P8BH38 | Long             | EC               | CORP              | AU        |    594162 | NS      | $1039783.50   | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Compass Pathways plc                           | Compass Pathways plc                                  | CUSIP: 20451W101<br>LEI: 213800N7CUZIC6QSTZ31 | Long             | EC               | CORP              | GB        |    377110 | NS      | $2160840.30   | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Tyra Biosciences, Inc.                         | Tyra Biosciences, Inc.                                | CUSIP: 90240B106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    196878 | NS      | $2754323.22   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Moderna, Inc.                                  | Moderna, Inc.                                         | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |   2025686 | NS      | $52323469.38  | 0.88%             |  |  |  | No            |                  1 | On Loan: No      |
| Dynavax Technologies Corp.                     | Dynavax Technologies Corp.                            | CUSIP: 268158201<br>LEI: 549300T5URIXWDILX594 | Long             | EC               | CORP              | US        |    687646 | NS      | $6828324.78   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Alkermes plc                                   | Alkermes plc                                          | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | IE        |    947648 | NS      | $28429440.00  | 0.48%             |  |  |  | No            |                  1 | On Loan: No      |
| Veracyte, Inc.                                 | Veracyte, Inc.                                        | CUSIP: 92337F107<br>LEI: 529900ESWZRHXOW27Z37 | Long             | EC               | CORP              | US        |    453231 | NS      | $15559420.23  | 0.26%             |  |  |  | No            |                  1 | On Loan: No      |
| Anavex Life Sciences Corp.                     | Anavex Life Sciences Corp.                            | CUSIP: 032797300<br>LEI: 549300K1I5L8COCQ8W36 | Long             | EC               | CORP              | US        |    489509 | NS      | $4356630.10   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Akouos, Inc.                                   | Akouos, Inc., CVR                                     | CUSIP: 009CVR036<br>LEI: N/A                  | Long             |  | CORP              | US        |    157087 | NS      | $1.57         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Terns Pharmaceuticals, Inc.                    | Terns Pharmaceuticals, Inc.                           | CUSIP: 880881107<br>LEI: 254900S1ZDQMF4MYP709 | Long             | EC               | CORP              | US        |    408459 | NS      | $3067527.09   | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| OmniAb Operations, Inc.                        | OmniAb, Inc., 12.50 Earnout Shares                    | CUSIP: 68218J202<br>LEI: N/A                  | Long             |  | CORP              | US        |     46839 | NS      | $0.47         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Neumora Therapeutics, Inc.                     | Neumora Therapeutics, Inc.                            | CUSIP: 640979100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    408119 | NS      | $742776.58    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2025-09-30

**Name of Applicant:** iShares Trust

**Signature:** Chuck Pulsfort

**Name of Signer:** Chuck Pulsfort

**Title:** Assistant Treasurer