# EDGAR Filing Document

**Accession Number:** 0000052848
**File Stem:** 0001752724-25-182554
**Filing Date:** 2025-7
**Character Count:** 216060
**Document Hash:** b0ee44133bedb4b145634bbcd05edbf9
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001752724-25-182554.hdr.sgml**: 20250729

**ACCESSION NUMBER**: 0001752724-25-182554

**CONFORMED SUBMISSION TYPE**: NPORT-P

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20250531

**FILED AS OF DATE**: 20250729

**DATE AS OF CHANGE**: 20250729

**PERIOD START**: 20250831

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** VANGUARD WORLD FUND
- **CENTRAL INDEX KEY:** 0000052848

**ORGANIZATION NAME:**
- **EIN:** 046035483
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 0831

**FILING VALUES:**
- **FORM TYPE:** NPORT-P
- **SEC ACT:** 1940 Act
- **SEC FILE NUMBER:** 811-01027
- **FILM NUMBER:** 251161267

**BUSINESS ADDRESS:**
- **STREET 1:** PO BOX 2600
- **STREET 2:** V26
- **CITY:** VALLEY FORGE
- **STATE:** PA
- **ZIP:** 19482
- **BUSINESS PHONE:** 6106691000

**MAIL ADDRESS:**
- **STREET 1:** PO BOX 2600
- **STREET 2:** V26
- **CITY:** VALLEY FORGE
- **STATE:** PA
- **ZIP:** 19482

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** VANGUARD WORLD FUNDS
- **DATE OF NAME CHANGE:** 20020402

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** VANGUARD WORLD FUND INC
- **DATE OF NAME CHANGE:** 19920703

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** IVEST FUND INC
- **DATE OF NAME CHANGE:** 19850923

## Series and Classes Contracts Data

### Vanguard Health Care Index Fund (Series ID: S000004450)

| Class ID   | Class Name     | Ticker Symbol   |
|:---|:---|:---|
| C000012222 | Admiral Shares | VHCIX           |
| C000012223 | ETF Shares     | VHT             |

## Nport-Ex

Vanguard<sup>®</sup> Health Care Index Fund

#### Schedule of Investments (unaudited)
As of May 31, 2025

The fund files its complete schedule of portfolio holdings with the Securities and Exchange Commission (SEC) for the first and third quarters of each fiscal year as an exhibit to its reports on Form N-PORT. The fund's Form N-PORT reports are available on the SEC's website at www.sec.gov.

---

| | | | |
|:---|:---|:---|:---|
|  |  | Shares | &nbsp;&nbsp;&nbsp;&nbsp;Market<br> Value<br> ($000) |
| **Common Stocks (97.0%)** | **Common Stocks (97.0%)** | **Common Stocks (97.0%)** | **Common Stocks (97.0%)** |
| **Biotechnology (19.6%)** | **Biotechnology (19.6%)** | **Biotechnology (19.6%)** | **Biotechnology (19.6%)** |
|  | &nbsp;&nbsp;&nbsp;AbbVie Inc. | 4681828 | &nbsp;&nbsp;&nbsp;&nbsp; 871335 |
|  | &nbsp;&nbsp;&nbsp;Amgen Inc. | 1681312 | &nbsp;&nbsp;&nbsp;&nbsp; 484520 |
|  | &nbsp;&nbsp;&nbsp;Gilead Sciences Inc. | 3898404 | &nbsp;&nbsp;&nbsp;&nbsp; 429136 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Vertex Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;803924 | &nbsp;&nbsp;&nbsp;&nbsp; 355375 |
|  | &nbsp;&nbsp;&nbsp;Regeneron Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;334450 | &nbsp;&nbsp;&nbsp;&nbsp; 163974 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Alnylam Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;406798 | &nbsp;&nbsp;&nbsp;&nbsp; 123894 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Natera Inc. | &nbsp;&nbsp;&nbsp;&nbsp;401614 | &nbsp;&nbsp;&nbsp;&nbsp; 63347 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Biogen Inc. | &nbsp;&nbsp;&nbsp;&nbsp;457748 | &nbsp;&nbsp;&nbsp;&nbsp; 59411 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;United Therapeutics Corp. | &nbsp;&nbsp;&nbsp;&nbsp;133428 | &nbsp;&nbsp;&nbsp;&nbsp; 42544 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Insmed Inc. | &nbsp;&nbsp;&nbsp;&nbsp;568603 | &nbsp;&nbsp;&nbsp;&nbsp; 39649 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Neurocrine Biosciences Inc. | &nbsp;&nbsp;&nbsp;&nbsp;309389 | &nbsp;&nbsp;&nbsp;&nbsp; 38061 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;BioMarin Pharmaceutical Inc. | &nbsp;&nbsp;&nbsp;&nbsp;599630 | &nbsp;&nbsp;&nbsp;&nbsp; 34821 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Exelixis Inc. | &nbsp;&nbsp;&nbsp;&nbsp;787178 | &nbsp;&nbsp;&nbsp;&nbsp; 33880 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Incyte Corp. | &nbsp;&nbsp;&nbsp;&nbsp;514405 | &nbsp;&nbsp;&nbsp;&nbsp; 33467 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Exact Sciences Corp. | &nbsp;&nbsp;&nbsp;&nbsp;580891 | &nbsp;&nbsp;&nbsp;&nbsp; 32693 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Moderna Inc. | 1088180 | &nbsp;&nbsp;&nbsp;&nbsp; 28902 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Halozyme Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;386315 | &nbsp;&nbsp;&nbsp;&nbsp; 21661 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Blueprint Medicines Corp. | &nbsp;&nbsp;&nbsp;&nbsp;199846 | &nbsp;&nbsp;&nbsp;&nbsp; 20254 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Revolution Medicines Inc. | &nbsp;&nbsp;&nbsp;&nbsp;436022 | &nbsp;&nbsp;&nbsp;&nbsp; 17179 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;TG Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;466650 | &nbsp;&nbsp;&nbsp;&nbsp; 16384 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Ionis Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;472276 | &nbsp;&nbsp;&nbsp;&nbsp; 15826 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Alkermes plc | &nbsp;&nbsp;&nbsp;&nbsp;489694 | &nbsp;&nbsp;&nbsp;&nbsp; 14990 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;ADMA Biologics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;743079 | &nbsp;&nbsp;&nbsp;&nbsp; 14743 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Bridgebio Pharma Inc. | &nbsp;&nbsp;&nbsp;&nbsp;416369 | &nbsp;&nbsp;&nbsp;&nbsp; 14261 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Madrigal Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;44886 | &nbsp;&nbsp;&nbsp;&nbsp; 12355 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Roivant Sciences Ltd. | 1115657 | &nbsp;&nbsp;&nbsp;&nbsp; 12261 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Vaxcyte Inc. | &nbsp;&nbsp;&nbsp;&nbsp;362398 | &nbsp;&nbsp;&nbsp;&nbsp; 11774 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Cytokinetics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;354089 | &nbsp;&nbsp;&nbsp;&nbsp; 10984 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;PTC Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;221984 | &nbsp;&nbsp;&nbsp;&nbsp; 10771 |
| <sup>\*,1</sup> | &nbsp;&nbsp;&nbsp;CRISPR Therapeutics AG | &nbsp;&nbsp;&nbsp;&nbsp;256064 | &nbsp;&nbsp;&nbsp;&nbsp; 9293 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Nuvalent Inc. Class A | &nbsp;&nbsp;&nbsp;&nbsp;124140 | &nbsp;&nbsp;&nbsp;&nbsp; 9262 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Rhythm Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;148287 | &nbsp;&nbsp;&nbsp;&nbsp; 9094 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Catalyst Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;362308 | &nbsp;&nbsp;&nbsp;&nbsp; 9043 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Ultragenyx Pharmaceutical Inc. | &nbsp;&nbsp;&nbsp;&nbsp;264262 | &nbsp;&nbsp;&nbsp;&nbsp; 8993 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Viking Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;333601 | &nbsp;&nbsp;&nbsp;&nbsp; 8941 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;SpringWorks Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;187595 | &nbsp;&nbsp;&nbsp;&nbsp; 8763 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Avidity Biosciences Inc. | &nbsp;&nbsp;&nbsp;&nbsp;281936 | &nbsp;&nbsp;&nbsp;&nbsp; 8734 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Akero Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;174305 | &nbsp;&nbsp;&nbsp;&nbsp; 8654 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Krystal Biotech Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;67901 | &nbsp;&nbsp;&nbsp;&nbsp; 8553 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Merus NV | &nbsp;&nbsp;&nbsp;&nbsp;151229 | &nbsp;&nbsp;&nbsp;&nbsp; 8479 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Crinetics Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;276414 | &nbsp;&nbsp;&nbsp;&nbsp; 8433 |
| <sup>\*,1</sup> | &nbsp;&nbsp;&nbsp;Summit Therapeutics Inc. (XNMS) | &nbsp;&nbsp;&nbsp;&nbsp;461849 | &nbsp;&nbsp;&nbsp;&nbsp; 8413 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Sarepta Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;208097 | &nbsp;&nbsp;&nbsp;&nbsp; 7824 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Soleno Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;102069 | &nbsp;&nbsp;&nbsp;&nbsp; 7487 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;ACADIA Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;338949 | &nbsp;&nbsp;&nbsp;&nbsp; 7311 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Protagonist Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;153573 | &nbsp;&nbsp;&nbsp;&nbsp; 7290 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;BioCryst Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;623218 | &nbsp;&nbsp;&nbsp;&nbsp; 6700 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Vericel Corp. | &nbsp;&nbsp;&nbsp;&nbsp;156765 | &nbsp;&nbsp;&nbsp;&nbsp; 6474 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Veracyte Inc. | &nbsp;&nbsp;&nbsp;&nbsp;243172 | &nbsp;&nbsp;&nbsp;&nbsp; 6471 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Arcellx Inc. | &nbsp;&nbsp;&nbsp;&nbsp;103093 | &nbsp;&nbsp;&nbsp;&nbsp; 6398 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Scholar Rock Holding Corp. | &nbsp;&nbsp;&nbsp;&nbsp;207685 | &nbsp;&nbsp;&nbsp;&nbsp; 6025 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Xenon Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;203977 | &nbsp;&nbsp;&nbsp;&nbsp; 5885 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Agios Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;179178 | &nbsp;&nbsp;&nbsp;&nbsp; 5750 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Arrowhead Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;343521 | &nbsp;&nbsp;&nbsp;&nbsp; 5520 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Twist Bioscience Corp. | &nbsp;&nbsp;&nbsp;&nbsp;186095 | &nbsp;&nbsp;&nbsp;&nbsp; 5453 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Denali Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;408691 | &nbsp;&nbsp;&nbsp;&nbsp; 5411 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Mirum Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;114935 | &nbsp;&nbsp;&nbsp;&nbsp; 5110 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Ideaya Biosciences Inc. | &nbsp;&nbsp;&nbsp;&nbsp;247285 | &nbsp;&nbsp;&nbsp;&nbsp; 4919 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Amicus Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;750812 | &nbsp;&nbsp;&nbsp;&nbsp; 4557 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Beam Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;279733 | &nbsp;&nbsp;&nbsp;&nbsp; 4428 |

---

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| | | | |
|:---|:---|:---|:---|
|  |  | Shares | &nbsp;&nbsp;&nbsp;&nbsp;Market<br> Value<br> ($000) |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Arcutis Biotherapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;333916 | &nbsp;&nbsp;&nbsp;&nbsp; 4354 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Biohaven Ltd. | &nbsp;&nbsp;&nbsp;&nbsp;271785 | &nbsp;&nbsp;&nbsp;&nbsp; 4025 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Apellis Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;235498 | &nbsp;&nbsp;&nbsp;&nbsp; 3987 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Travere Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;263745 | &nbsp;&nbsp;&nbsp;&nbsp; 3961 |
| <sup>\*,1</sup> | &nbsp;&nbsp;&nbsp;Recursion Pharmaceuticals Inc. Class A | &nbsp;&nbsp;&nbsp;&nbsp;926967 | &nbsp;&nbsp;&nbsp;&nbsp; 3875 |
| <sup>\*,1</sup> | &nbsp;&nbsp;&nbsp;GRAIL Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;99345 | &nbsp;&nbsp;&nbsp;&nbsp; 3816 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;MannKind Corp. | &nbsp;&nbsp;&nbsp;&nbsp;902578 | &nbsp;&nbsp;&nbsp;&nbsp; 3746 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Celldex Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;187696 | &nbsp;&nbsp;&nbsp;&nbsp; 3713 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Kymera Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;121907 | &nbsp;&nbsp;&nbsp;&nbsp; 3613 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;CG oncology Inc. | &nbsp;&nbsp;&nbsp;&nbsp;131571 | &nbsp;&nbsp;&nbsp;&nbsp; 3371 |
| <sup>\*,1</sup> | &nbsp;&nbsp;&nbsp;Novavax Inc. | &nbsp;&nbsp;&nbsp;&nbsp;452837 | &nbsp;&nbsp;&nbsp;&nbsp; 3324 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Disc Medicine Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;70251 | &nbsp;&nbsp;&nbsp;&nbsp; 3279 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Immunovant Inc. | &nbsp;&nbsp;&nbsp;&nbsp;212348 | &nbsp;&nbsp;&nbsp;&nbsp; 3153 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;89bio Inc. | &nbsp;&nbsp;&nbsp;&nbsp;319508 | &nbsp;&nbsp;&nbsp;&nbsp; 3144 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Janux Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;128963 | &nbsp;&nbsp;&nbsp;&nbsp; 3069 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Dynavax Technologies Corp. | &nbsp;&nbsp;&nbsp;&nbsp;306171 | &nbsp;&nbsp;&nbsp;&nbsp; 2997 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Kiniksa Pharmaceuticals International plc | &nbsp;&nbsp;&nbsp;&nbsp;105839 | &nbsp;&nbsp;&nbsp;&nbsp; 2896 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Aurinia Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;365041 | &nbsp;&nbsp;&nbsp;&nbsp; 2862 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Syndax Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;269069 | &nbsp;&nbsp;&nbsp;&nbsp; 2836 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;CareDx Inc. | &nbsp;&nbsp;&nbsp;&nbsp;164679 | &nbsp;&nbsp;&nbsp;&nbsp; 2798 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Dyne Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;229905 | &nbsp;&nbsp;&nbsp;&nbsp; 2750 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;MoonLake Immunotherapeutics | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;69854 | &nbsp;&nbsp;&nbsp;&nbsp; 2725 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Ardelyx Inc. | &nbsp;&nbsp;&nbsp;&nbsp;740170 | &nbsp;&nbsp;&nbsp;&nbsp; 2716 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Vera Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;139306 | &nbsp;&nbsp;&nbsp;&nbsp; 2640 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Apogee Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;69419 | &nbsp;&nbsp;&nbsp;&nbsp; 2544 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Newamsterdam Pharma Co. NV | &nbsp;&nbsp;&nbsp;&nbsp;137416 | &nbsp;&nbsp;&nbsp;&nbsp; 2489 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Viridian Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;178328 | &nbsp;&nbsp;&nbsp;&nbsp; 2482 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Geron Corp. (XNGS) | 1576187 | &nbsp;&nbsp;&nbsp;&nbsp; 2396 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;MiMedx Group Inc. | &nbsp;&nbsp;&nbsp;&nbsp;369304 | &nbsp;&nbsp;&nbsp;&nbsp; 2375 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Nurix Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;214485 | &nbsp;&nbsp;&nbsp;&nbsp; 2280 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Akebia Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;739261 | &nbsp;&nbsp;&nbsp;&nbsp; 2240 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Intellia Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;308544 | &nbsp;&nbsp;&nbsp;&nbsp; 2120 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;ARS Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;138111 | &nbsp;&nbsp;&nbsp;&nbsp; 1993 |
| <sup>\*,1</sup> | &nbsp;&nbsp;&nbsp;Anavex Life Sciences Corp. | &nbsp;&nbsp;&nbsp;&nbsp;263713 | &nbsp;&nbsp;&nbsp;&nbsp; 1986 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Praxis Precision Medicines Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;50432 | &nbsp;&nbsp;&nbsp;&nbsp; 1944 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Immunome Inc. | &nbsp;&nbsp;&nbsp;&nbsp;217463 | &nbsp;&nbsp;&nbsp;&nbsp; 1905 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;uniQure NV | &nbsp;&nbsp;&nbsp;&nbsp;126825 | &nbsp;&nbsp;&nbsp;&nbsp; 1835 |
| <sup>\*,1</sup> | &nbsp;&nbsp;&nbsp;ImmunityBio Inc. | &nbsp;&nbsp;&nbsp;&nbsp;689971 | &nbsp;&nbsp;&nbsp;&nbsp; 1835 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Arcus Biosciences Inc. | &nbsp;&nbsp;&nbsp;&nbsp;198474 | &nbsp;&nbsp;&nbsp;&nbsp; 1772 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Spyre Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;113264 | &nbsp;&nbsp;&nbsp;&nbsp; 1731 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Mineralys Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;101435 | &nbsp;&nbsp;&nbsp;&nbsp; 1580 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Xencor Inc. | &nbsp;&nbsp;&nbsp;&nbsp;187044 | &nbsp;&nbsp;&nbsp;&nbsp; 1496 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Arbutus Biopharma Corp. | &nbsp;&nbsp;&nbsp;&nbsp;445275 | &nbsp;&nbsp;&nbsp;&nbsp; 1496 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Iovance Biotherapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;820392 | &nbsp;&nbsp;&nbsp;&nbsp; 1436 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Vir Biotechnology Inc. | &nbsp;&nbsp;&nbsp;&nbsp;278941 | &nbsp;&nbsp;&nbsp;&nbsp; 1378 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Zymeworks Inc. | &nbsp;&nbsp;&nbsp;&nbsp;119548 | &nbsp;&nbsp;&nbsp;&nbsp; 1366 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Day One Biopharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;205929 | &nbsp;&nbsp;&nbsp;&nbsp; 1314 |
| <sup>\*,1</sup> | &nbsp;&nbsp;&nbsp;Altimmune Inc. | &nbsp;&nbsp;&nbsp;&nbsp;240783 | &nbsp;&nbsp;&nbsp;&nbsp; 1307 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Cogent Biosciences Inc. | &nbsp;&nbsp;&nbsp;&nbsp;236059 | &nbsp;&nbsp;&nbsp;&nbsp; 1284 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Myriad Genetics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;285580 | &nbsp;&nbsp;&nbsp;&nbsp; 1197 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;KalVista Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;101067 | &nbsp;&nbsp;&nbsp;&nbsp; 1193 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;REGENXBIO Inc. | &nbsp;&nbsp;&nbsp;&nbsp;131744 | &nbsp;&nbsp;&nbsp;&nbsp; 1166 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Relay Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;369808 | &nbsp;&nbsp;&nbsp;&nbsp; 1109 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Replimune Group Inc. | &nbsp;&nbsp;&nbsp;&nbsp;120322 | &nbsp;&nbsp;&nbsp;&nbsp; 1080 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Kura Oncology Inc. | &nbsp;&nbsp;&nbsp;&nbsp;189235 | &nbsp;&nbsp;&nbsp;&nbsp; 1077 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Keros Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;76077 | &nbsp;&nbsp;&nbsp;&nbsp; 1076 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Emergent BioSolutions Inc. | &nbsp;&nbsp;&nbsp;&nbsp;170019 | &nbsp;&nbsp;&nbsp;&nbsp; 1075 |
| <sup>\*,1</sup> | &nbsp;&nbsp;&nbsp;Humacyte Inc. | &nbsp;&nbsp;&nbsp;&nbsp;385077 | &nbsp;&nbsp;&nbsp;&nbsp; 1028 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Stoke Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;101434 | &nbsp;&nbsp;&nbsp;&nbsp; 968 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;AnaptysBio Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;43144 | &nbsp;&nbsp;&nbsp;&nbsp; 959 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Taysha Gene Therapies Inc. | &nbsp;&nbsp;&nbsp;&nbsp;352835 | &nbsp;&nbsp;&nbsp;&nbsp; 956 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Sage Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;142890 | &nbsp;&nbsp;&nbsp;&nbsp; 923 |
| <sup>\*,1</sup> | &nbsp;&nbsp;&nbsp;Sana Biotechnology Inc. | &nbsp;&nbsp;&nbsp;&nbsp;422185 | &nbsp;&nbsp;&nbsp;&nbsp; 916 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Arcturus Therapeutics Holdings Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;72040 | &nbsp;&nbsp;&nbsp;&nbsp; 903 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;ArriVent Biopharma Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;42199 | &nbsp;&nbsp;&nbsp;&nbsp; 897 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;iTeos Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;83567 | &nbsp;&nbsp;&nbsp;&nbsp; 837 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;ORIC Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;99882 | &nbsp;&nbsp;&nbsp;&nbsp; 816 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Verve Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;180491 | &nbsp;&nbsp;&nbsp;&nbsp; 803 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Vanda Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;184365 | &nbsp;&nbsp;&nbsp;&nbsp; 800 |
| <sup>\*,1</sup> | &nbsp;&nbsp;&nbsp;Ocugen Inc. | &nbsp;&nbsp;&nbsp;&nbsp;904585 | &nbsp;&nbsp;&nbsp;&nbsp; 756 |

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| | | | |
|:---|:---|:---|:---|
|  |  | Shares | &nbsp;&nbsp;&nbsp;&nbsp;Market<br> Value<br> ($000) |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Erasca Inc. | &nbsp;&nbsp;&nbsp;&nbsp;534095 | &nbsp;&nbsp;&nbsp;&nbsp; 748 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Heron Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;382856 | &nbsp;&nbsp;&nbsp;&nbsp; 720 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Cullinan Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;82134 | &nbsp;&nbsp;&nbsp;&nbsp; 710 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;MeiraGTx Holdings plc | &nbsp;&nbsp;&nbsp;&nbsp;135459 | &nbsp;&nbsp;&nbsp;&nbsp; 694 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Aura Biosciences Inc. | &nbsp;&nbsp;&nbsp;&nbsp;117640 | &nbsp;&nbsp;&nbsp;&nbsp; 689 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Rocket Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;251604 | &nbsp;&nbsp;&nbsp;&nbsp; 632 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Olema Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;117436 | &nbsp;&nbsp;&nbsp;&nbsp; 620 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Savara Inc. | &nbsp;&nbsp;&nbsp;&nbsp;242622 | &nbsp;&nbsp;&nbsp;&nbsp; 553 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Allogene Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;459502 | &nbsp;&nbsp;&nbsp;&nbsp; 538 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Monte Rosa Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;125627 | &nbsp;&nbsp;&nbsp;&nbsp; 525 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Annexon Inc. | &nbsp;&nbsp;&nbsp;&nbsp;240685 | &nbsp;&nbsp;&nbsp;&nbsp; 491 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Organogenesis Holdings Inc. | &nbsp;&nbsp;&nbsp;&nbsp;173043 | &nbsp;&nbsp;&nbsp;&nbsp; 474 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Editas Medicine Inc. | &nbsp;&nbsp;&nbsp;&nbsp;274633 | &nbsp;&nbsp;&nbsp;&nbsp; 472 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Entrada Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;59341 | &nbsp;&nbsp;&nbsp;&nbsp; 451 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Dianthus Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;25954 | &nbsp;&nbsp;&nbsp;&nbsp; 451 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Perspective Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;173613 | &nbsp;&nbsp;&nbsp;&nbsp; 446 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Astria Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;91769 | &nbsp;&nbsp;&nbsp;&nbsp; 437 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Tyra Biosciences Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;47743 | &nbsp;&nbsp;&nbsp;&nbsp; 434 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Prothena Corp. plc | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;92519 | &nbsp;&nbsp;&nbsp;&nbsp; 425 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Y-mAbs Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;84645 | &nbsp;&nbsp;&nbsp;&nbsp; 389 |
| <sup>\*,1</sup> | &nbsp;&nbsp;&nbsp;Lexicon Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;569490 | &nbsp;&nbsp;&nbsp;&nbsp; 357 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;4D Molecular Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;96342 | &nbsp;&nbsp;&nbsp;&nbsp; 349 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Fate Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;268865 | &nbsp;&nbsp;&nbsp;&nbsp; 325 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Bicara Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;34125 | &nbsp;&nbsp;&nbsp;&nbsp; 316 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Aldeyra Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;139257 | &nbsp;&nbsp;&nbsp;&nbsp; 299 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Coherus Biosciences Inc. | &nbsp;&nbsp;&nbsp;&nbsp;363854 | &nbsp;&nbsp;&nbsp;&nbsp; 283 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Cabaletta Bio Inc. | &nbsp;&nbsp;&nbsp;&nbsp;150740 | &nbsp;&nbsp;&nbsp;&nbsp; 282 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Alector Inc. | &nbsp;&nbsp;&nbsp;&nbsp;210784 | &nbsp;&nbsp;&nbsp;&nbsp; 280 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Ironwood Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;452844 | &nbsp;&nbsp;&nbsp;&nbsp; 271 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Tango Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;118574 | &nbsp;&nbsp;&nbsp;&nbsp; 263 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Agenus Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;74035 | &nbsp;&nbsp;&nbsp;&nbsp; 254 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Cargo Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;43108 | &nbsp;&nbsp;&nbsp;&nbsp; 183 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;MacroGenics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;129034 | &nbsp;&nbsp;&nbsp;&nbsp; 175 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Korro Bio Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;14213 | &nbsp;&nbsp;&nbsp;&nbsp; 162 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;HilleVax Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;85655 | &nbsp;&nbsp;&nbsp;&nbsp; 160 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Lyell Immunopharma Inc. | &nbsp;&nbsp;&nbsp;&nbsp;344760 | &nbsp;&nbsp;&nbsp;&nbsp; 151 |
| <sup>\*,1</sup> | &nbsp;&nbsp;&nbsp;Prime Medicine Inc. | &nbsp;&nbsp;&nbsp;&nbsp;127060 | &nbsp;&nbsp;&nbsp;&nbsp; 150 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Zentalis Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;114950 | &nbsp;&nbsp;&nbsp;&nbsp; 139 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Mural Oncology plc | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;47262 | &nbsp;&nbsp;&nbsp;&nbsp; 124 |
| <sup>\*,1</sup> | &nbsp;&nbsp;&nbsp;Biomea Fusion Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;79574 | &nbsp;&nbsp;&nbsp;&nbsp; 115 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Applied Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;235036 | &nbsp;&nbsp;&nbsp;&nbsp; 83 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;IGM Biosciences Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;36745 | &nbsp;&nbsp;&nbsp;&nbsp; 47 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;ALX Oncology Holdings Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;79353 | &nbsp;&nbsp;&nbsp;&nbsp; 39 |
| <sup>\*,1</sup> | &nbsp;&nbsp;&nbsp;Seres Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5093 | &nbsp;&nbsp;&nbsp;&nbsp; 36 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;FibroGen Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;91195 | &nbsp;&nbsp;&nbsp;&nbsp; 26 |
| <sup>\*,2</sup> | &nbsp;&nbsp;&nbsp;Prevail Therapeutics CVR | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;78 | &nbsp;&nbsp;&nbsp;&nbsp; — |
|  |  |  | &nbsp;&nbsp;&nbsp;&nbsp; **3414657** |
| **Health Care Equipment & Supplies (23.3%)** | **Health Care Equipment & Supplies (23.3%)** | **Health Care Equipment & Supplies (23.3%)** | **Health Care Equipment & Supplies (23.3%)** |
|  | &nbsp;&nbsp;&nbsp;Abbott Laboratories | 5423412 | &nbsp;&nbsp;&nbsp;&nbsp; 724459 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Intuitive Surgical Inc. | 1120367 | &nbsp;&nbsp;&nbsp;&nbsp; 618823 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Boston Scientific Corp. | 4625170 | &nbsp;&nbsp;&nbsp;&nbsp; 486845 |
|  | &nbsp;&nbsp;&nbsp;Stryker Corp. | 1074207 | &nbsp;&nbsp;&nbsp;&nbsp; 411035 |
|  | &nbsp;&nbsp;&nbsp;Medtronic plc | 4010636 | &nbsp;&nbsp;&nbsp;&nbsp; 332803 |
|  | &nbsp;&nbsp;&nbsp;Becton Dickinson & Co. | &nbsp;&nbsp;&nbsp;&nbsp;897876 | &nbsp;&nbsp;&nbsp;&nbsp; 154964 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Edwards Lifesciences Corp. | 1831683 | &nbsp;&nbsp;&nbsp;&nbsp; 143274 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;IDEXX Laboratories Inc. | &nbsp;&nbsp;&nbsp;&nbsp;253413 | &nbsp;&nbsp;&nbsp;&nbsp; 130092 |
|  | &nbsp;&nbsp;&nbsp;ResMed Inc. | &nbsp;&nbsp;&nbsp;&nbsp;459263 | &nbsp;&nbsp;&nbsp;&nbsp; 112423 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Dexcom Inc. | 1226164 | &nbsp;&nbsp;&nbsp;&nbsp; 105205 |
|  | &nbsp;&nbsp;&nbsp;GE HealthCare Technologies Inc. | 1431713 | &nbsp;&nbsp;&nbsp;&nbsp; 100993 |
|  | &nbsp;&nbsp;&nbsp;STERIS plc | &nbsp;&nbsp;&nbsp;&nbsp;307221 | &nbsp;&nbsp;&nbsp;&nbsp; 75334 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Insulet Corp. | &nbsp;&nbsp;&nbsp;&nbsp;219630 | &nbsp;&nbsp;&nbsp;&nbsp; 71386 |
|  | &nbsp;&nbsp;&nbsp;Zimmer Biomet Holdings Inc. | &nbsp;&nbsp;&nbsp;&nbsp;618646 | &nbsp;&nbsp;&nbsp;&nbsp; 57021 |
|  | &nbsp;&nbsp;&nbsp;Baxter International Inc. | 1603953 | &nbsp;&nbsp;&nbsp;&nbsp; 48921 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Hologic Inc. | &nbsp;&nbsp;&nbsp;&nbsp;701667 | &nbsp;&nbsp;&nbsp;&nbsp; 43623 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Cooper Cos. Inc. | &nbsp;&nbsp;&nbsp;&nbsp;625526 | &nbsp;&nbsp;&nbsp;&nbsp; 42711 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Align Technology Inc. | &nbsp;&nbsp;&nbsp;&nbsp;217484 | &nbsp;&nbsp;&nbsp;&nbsp; 39351 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Solventum Corp. | &nbsp;&nbsp;&nbsp;&nbsp;459558 | &nbsp;&nbsp;&nbsp;&nbsp; 33589 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Penumbra Inc. | &nbsp;&nbsp;&nbsp;&nbsp;114918 | &nbsp;&nbsp;&nbsp;&nbsp; 30680 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Masimo Corp. | &nbsp;&nbsp;&nbsp;&nbsp;143619 | &nbsp;&nbsp;&nbsp;&nbsp; 23338 |

---

------

---

| | | | |
|:---|:---|:---|:---|
|  |  | Shares | &nbsp;&nbsp;&nbsp;&nbsp;Market<br> Value<br> ($000) |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Merit Medical Systems Inc. | &nbsp;&nbsp;&nbsp;&nbsp;184676 | &nbsp;&nbsp;&nbsp;&nbsp; 17550 |
|  | &nbsp;&nbsp;&nbsp;Teleflex Inc. | &nbsp;&nbsp;&nbsp;&nbsp;139716 | &nbsp;&nbsp;&nbsp;&nbsp; 17083 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Glaukos Corp. | &nbsp;&nbsp;&nbsp;&nbsp;176882 | &nbsp;&nbsp;&nbsp;&nbsp; 16678 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Lantheus Holdings Inc. | &nbsp;&nbsp;&nbsp;&nbsp;214144 | &nbsp;&nbsp;&nbsp;&nbsp; 16181 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Globus Medical Inc. Class A | &nbsp;&nbsp;&nbsp;&nbsp;259919 | &nbsp;&nbsp;&nbsp;&nbsp; 15382 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;iRhythm Technologies Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;98193 | &nbsp;&nbsp;&nbsp;&nbsp; 13796 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Inspire Medical Systems Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;93059 | &nbsp;&nbsp;&nbsp;&nbsp; 12861 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;TransMedics Group Inc. | &nbsp;&nbsp;&nbsp;&nbsp;100000 | &nbsp;&nbsp;&nbsp;&nbsp; 12712 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Integer Holdings Corp. | &nbsp;&nbsp;&nbsp;&nbsp;105336 | &nbsp;&nbsp;&nbsp;&nbsp; 12510 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Haemonetics Corp. | &nbsp;&nbsp;&nbsp;&nbsp;157009 | &nbsp;&nbsp;&nbsp;&nbsp; 10631 |
|  | &nbsp;&nbsp;&nbsp;DENTSPLY SIRONA Inc. | &nbsp;&nbsp;&nbsp;&nbsp;624283 | &nbsp;&nbsp;&nbsp;&nbsp; 9976 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;ICU Medical Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;73114 | &nbsp;&nbsp;&nbsp;&nbsp; 9860 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Envista Holdings Corp. | &nbsp;&nbsp;&nbsp;&nbsp;537875 | &nbsp;&nbsp;&nbsp;&nbsp; 9827 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;PROCEPT BioRobotics Corp. | &nbsp;&nbsp;&nbsp;&nbsp;162842 | &nbsp;&nbsp;&nbsp;&nbsp; 9445 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;LivaNova plc | &nbsp;&nbsp;&nbsp;&nbsp;169728 | &nbsp;&nbsp;&nbsp;&nbsp; 7341 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;QuidelOrtho Corp. | &nbsp;&nbsp;&nbsp;&nbsp;211646 | &nbsp;&nbsp;&nbsp;&nbsp; 6491 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Novocure Ltd. | &nbsp;&nbsp;&nbsp;&nbsp;326503 | &nbsp;&nbsp;&nbsp;&nbsp; 6239 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;UFP Technologies Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;23956 | &nbsp;&nbsp;&nbsp;&nbsp; 5610 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Enovis Corp. | &nbsp;&nbsp;&nbsp;&nbsp;178475 | &nbsp;&nbsp;&nbsp;&nbsp; 5586 |
|  | &nbsp;&nbsp;&nbsp;CONMED Corp. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;96539 | &nbsp;&nbsp;&nbsp;&nbsp; 5479 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;AtriCure Inc. | &nbsp;&nbsp;&nbsp;&nbsp;154744 | &nbsp;&nbsp;&nbsp;&nbsp; 5349 |
|  | &nbsp;&nbsp;&nbsp;LeMaitre Vascular Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;63744 | &nbsp;&nbsp;&nbsp;&nbsp; 5240 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Alphatec Holdings Inc. | &nbsp;&nbsp;&nbsp;&nbsp;360553 | &nbsp;&nbsp;&nbsp;&nbsp; 4482 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Omnicell Inc. | &nbsp;&nbsp;&nbsp;&nbsp;146458 | &nbsp;&nbsp;&nbsp;&nbsp; 4448 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Tandem Diabetes Care Inc. | &nbsp;&nbsp;&nbsp;&nbsp;208200 | &nbsp;&nbsp;&nbsp;&nbsp; 4126 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Neogen Corp. | &nbsp;&nbsp;&nbsp;&nbsp;647375 | &nbsp;&nbsp;&nbsp;&nbsp; 3794 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Artivion Inc. | &nbsp;&nbsp;&nbsp;&nbsp;113354 | &nbsp;&nbsp;&nbsp;&nbsp; 3353 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Integra LifeSciences Holdings Corp. | &nbsp;&nbsp;&nbsp;&nbsp;218164 | &nbsp;&nbsp;&nbsp;&nbsp; 2762 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;SI-BONE Inc. | &nbsp;&nbsp;&nbsp;&nbsp;120168 | &nbsp;&nbsp;&nbsp;&nbsp; 2271 |
| <sup>\*,1</sup> | &nbsp;&nbsp;&nbsp;Establishment Labs Holdings Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;63279 | &nbsp;&nbsp;&nbsp;&nbsp; 2178 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;STAAR Surgical Co. | &nbsp;&nbsp;&nbsp;&nbsp;107920 | &nbsp;&nbsp;&nbsp;&nbsp; 1922 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Avanos Medical Inc. | &nbsp;&nbsp;&nbsp;&nbsp;145052 | &nbsp;&nbsp;&nbsp;&nbsp; 1823 |
|  | &nbsp;&nbsp;&nbsp;Embecta Corp. | &nbsp;&nbsp;&nbsp;&nbsp;172615 | &nbsp;&nbsp;&nbsp;&nbsp; 1818 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;RxSight Inc. | &nbsp;&nbsp;&nbsp;&nbsp;107791 | &nbsp;&nbsp;&nbsp;&nbsp; 1648 |
|  | &nbsp;&nbsp;&nbsp;iRadimed Corp. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;25727 | &nbsp;&nbsp;&nbsp;&nbsp; 1489 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Axogen Inc. | &nbsp;&nbsp;&nbsp;&nbsp;124816 | &nbsp;&nbsp;&nbsp;&nbsp; 1359 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Butterfly Network Inc. | &nbsp;&nbsp;&nbsp;&nbsp;541558 | &nbsp;&nbsp;&nbsp;&nbsp; 1300 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;AngioDynamics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;126649 | &nbsp;&nbsp;&nbsp;&nbsp; 1292 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Surmodics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;42649 | &nbsp;&nbsp;&nbsp;&nbsp; 1238 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Orthofix Medical Inc. | &nbsp;&nbsp;&nbsp;&nbsp;102035 | &nbsp;&nbsp;&nbsp;&nbsp; 1148 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;OrthoPediatrics Corp. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;49459 | &nbsp;&nbsp;&nbsp;&nbsp; 987 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Varex Imaging Corp. | &nbsp;&nbsp;&nbsp;&nbsp;128302 | &nbsp;&nbsp;&nbsp;&nbsp; 984 |
| <sup>\*,1</sup> | &nbsp;&nbsp;&nbsp;Pulse Biosciences Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;52564 | &nbsp;&nbsp;&nbsp;&nbsp; 910 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Treace Medical Concepts Inc. | &nbsp;&nbsp;&nbsp;&nbsp;156403 | &nbsp;&nbsp;&nbsp;&nbsp; 898 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Zimvie Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;87641 | &nbsp;&nbsp;&nbsp;&nbsp; 801 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Cerus Corp. | &nbsp;&nbsp;&nbsp;&nbsp;589905 | &nbsp;&nbsp;&nbsp;&nbsp; 749 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Bioventus Inc. Class A | &nbsp;&nbsp;&nbsp;&nbsp;112843 | &nbsp;&nbsp;&nbsp;&nbsp; 731 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;OraSure Technologies Inc. | &nbsp;&nbsp;&nbsp;&nbsp;250465 | &nbsp;&nbsp;&nbsp;&nbsp; 721 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Ceribell Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;39208 | &nbsp;&nbsp;&nbsp;&nbsp; 659 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Pulmonx Corp. | &nbsp;&nbsp;&nbsp;&nbsp;114050 | &nbsp;&nbsp;&nbsp;&nbsp; 388 |
|  |  |  | &nbsp;&nbsp;&nbsp;&nbsp; **4068976** |
| **Health Care Providers & Services (18.7%)** | **Health Care Providers & Services (18.7%)** | **Health Care Providers & Services (18.7%)** | **Health Care Providers & Services (18.7%)** |
|  | &nbsp;&nbsp;&nbsp;UnitedHealth Group Inc. | 2860409 | &nbsp;&nbsp;&nbsp;&nbsp; 863586 |
|  | &nbsp;&nbsp;&nbsp;McKesson Corp. | &nbsp;&nbsp;&nbsp;&nbsp;391904 | &nbsp;&nbsp;&nbsp;&nbsp; 281979 |
|  | &nbsp;&nbsp;&nbsp;Elevance Health Inc. | &nbsp;&nbsp;&nbsp;&nbsp;707926 | &nbsp;&nbsp;&nbsp;&nbsp; 271730 |
|  | &nbsp;&nbsp;&nbsp;Cigna Group | &nbsp;&nbsp;&nbsp;&nbsp;847770 | &nbsp;&nbsp;&nbsp;&nbsp; 268438 |
|  | &nbsp;&nbsp;&nbsp;CVS Health Corp. | 3947644 | &nbsp;&nbsp;&nbsp;&nbsp; 252807 |
|  | &nbsp;&nbsp;&nbsp;HCA Healthcare Inc. | &nbsp;&nbsp;&nbsp;&nbsp;577422 | &nbsp;&nbsp;&nbsp;&nbsp; 220223 |
|  | &nbsp;&nbsp;&nbsp;Cencora Inc. | &nbsp;&nbsp;&nbsp;&nbsp;576105 | &nbsp;&nbsp;&nbsp;&nbsp; 167785 |
|  | &nbsp;&nbsp;&nbsp;Cardinal Health Inc. | &nbsp;&nbsp;&nbsp;&nbsp;755402 | &nbsp;&nbsp;&nbsp;&nbsp; 116664 |
|  | &nbsp;&nbsp;&nbsp;Humana Inc. | &nbsp;&nbsp;&nbsp;&nbsp;377421 | &nbsp;&nbsp;&nbsp;&nbsp; 87988 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Centene Corp. | 1551210 | &nbsp;&nbsp;&nbsp;&nbsp; 87550 |
|  | &nbsp;&nbsp;&nbsp;Labcorp Holdings Inc. | &nbsp;&nbsp;&nbsp;&nbsp;261637 | &nbsp;&nbsp;&nbsp;&nbsp; 65140 |
|  | &nbsp;&nbsp;&nbsp;Quest Diagnostics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;349026 | &nbsp;&nbsp;&nbsp;&nbsp; 60500 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Molina Healthcare Inc. | &nbsp;&nbsp;&nbsp;&nbsp;171047 | &nbsp;&nbsp;&nbsp;&nbsp; 52176 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Tenet Healthcare Corp. | &nbsp;&nbsp;&nbsp;&nbsp;295118 | &nbsp;&nbsp;&nbsp;&nbsp; 49807 |
|  | &nbsp;&nbsp;&nbsp;Encompass Health Corp. | &nbsp;&nbsp;&nbsp;&nbsp;315777 | &nbsp;&nbsp;&nbsp;&nbsp; 38178 |
|  | &nbsp;&nbsp;&nbsp;Universal Health Services Inc. Class B | &nbsp;&nbsp;&nbsp;&nbsp;181224 | &nbsp;&nbsp;&nbsp;&nbsp; 34496 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Hims & Hers Health Inc. | &nbsp;&nbsp;&nbsp;&nbsp;568272 | &nbsp;&nbsp;&nbsp;&nbsp; 32142 |

---

------

---

| | | | |
|:---|:---|:---|:---|
|  |  | Shares | &nbsp;&nbsp;&nbsp;&nbsp;Market<br> Value<br> ($000) |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;HealthEquity Inc. | &nbsp;&nbsp;&nbsp;&nbsp;270463 | &nbsp;&nbsp;&nbsp;&nbsp; 27211 |
|  | &nbsp;&nbsp;&nbsp;Ensign Group Inc. | &nbsp;&nbsp;&nbsp;&nbsp;179557 | &nbsp;&nbsp;&nbsp;&nbsp; 26442 |
|  | &nbsp;&nbsp;&nbsp;Chemed Corp. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;45698 | &nbsp;&nbsp;&nbsp;&nbsp; 26269 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Henry Schein Inc. | &nbsp;&nbsp;&nbsp;&nbsp;344760 | &nbsp;&nbsp;&nbsp;&nbsp; 24130 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;DaVita Inc. | &nbsp;&nbsp;&nbsp;&nbsp;137598 | &nbsp;&nbsp;&nbsp;&nbsp; 18749 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Option Care Health Inc. | &nbsp;&nbsp;&nbsp;&nbsp;513586 | &nbsp;&nbsp;&nbsp;&nbsp; 16784 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Guardant Health Inc. | &nbsp;&nbsp;&nbsp;&nbsp;347340 | &nbsp;&nbsp;&nbsp;&nbsp; 14109 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;RadNet Inc. | &nbsp;&nbsp;&nbsp;&nbsp;196774 | &nbsp;&nbsp;&nbsp;&nbsp; 11313 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;CorVel Corp. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;96337 | &nbsp;&nbsp;&nbsp;&nbsp; 10719 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Amedisys Inc. | &nbsp;&nbsp;&nbsp;&nbsp;102785 | &nbsp;&nbsp;&nbsp;&nbsp; 9669 |
|  | &nbsp;&nbsp;&nbsp;Concentra Group Holdings Parent Inc. | &nbsp;&nbsp;&nbsp;&nbsp;360660 | &nbsp;&nbsp;&nbsp;&nbsp; 7801 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Privia Health Group Inc. | &nbsp;&nbsp;&nbsp;&nbsp;303418 | &nbsp;&nbsp;&nbsp;&nbsp; 6906 |
|  | &nbsp;&nbsp;&nbsp;Premier Inc. Class A | &nbsp;&nbsp;&nbsp;&nbsp;285471 | &nbsp;&nbsp;&nbsp;&nbsp; 6560 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Acadia Healthcare Co. Inc. | &nbsp;&nbsp;&nbsp;&nbsp;288077 | &nbsp;&nbsp;&nbsp;&nbsp; 6522 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Addus HomeCare Corp. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;56932 | &nbsp;&nbsp;&nbsp;&nbsp; 6314 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Surgery Partners Inc. | &nbsp;&nbsp;&nbsp;&nbsp;239423 | &nbsp;&nbsp;&nbsp;&nbsp; 5653 |
|  | &nbsp;&nbsp;&nbsp;Select Medical Holdings Corp. | &nbsp;&nbsp;&nbsp;&nbsp;362844 | &nbsp;&nbsp;&nbsp;&nbsp; 5548 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;BrightSpring Health Services Inc. | &nbsp;&nbsp;&nbsp;&nbsp;218866 | &nbsp;&nbsp;&nbsp;&nbsp; 5211 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Alignment Healthcare Inc. | &nbsp;&nbsp;&nbsp;&nbsp;329952 | &nbsp;&nbsp;&nbsp;&nbsp; 5071 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Progyny Inc. | &nbsp;&nbsp;&nbsp;&nbsp;227407 | &nbsp;&nbsp;&nbsp;&nbsp; 4889 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;GeneDx Holdings Corp. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;61452 | &nbsp;&nbsp;&nbsp;&nbsp; 4377 |
|  | &nbsp;&nbsp;&nbsp;National HealthCare Corp. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;41290 | &nbsp;&nbsp;&nbsp;&nbsp; 4300 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Clover Health Investments Corp. | 1245775 | &nbsp;&nbsp;&nbsp;&nbsp; 3912 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Pediatrix Medical Group Inc. | &nbsp;&nbsp;&nbsp;&nbsp;266492 | &nbsp;&nbsp;&nbsp;&nbsp; 3771 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Brookdale Senior Living Inc. | &nbsp;&nbsp;&nbsp;&nbsp;563326 | &nbsp;&nbsp;&nbsp;&nbsp; 3667 |
|  | &nbsp;&nbsp;&nbsp;US Physical Therapy Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;47390 | &nbsp;&nbsp;&nbsp;&nbsp; 3554 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Astrana Health Inc. | &nbsp;&nbsp;&nbsp;&nbsp;141336 | &nbsp;&nbsp;&nbsp;&nbsp; 3504 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Pennant Group Inc. | &nbsp;&nbsp;&nbsp;&nbsp;107963 | &nbsp;&nbsp;&nbsp;&nbsp; 3100 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;NeoGenomics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;401360 | &nbsp;&nbsp;&nbsp;&nbsp; 2922 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;AMN Healthcare Services Inc. | &nbsp;&nbsp;&nbsp;&nbsp;119721 | &nbsp;&nbsp;&nbsp;&nbsp; 2527 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;LifeStance Health Group Inc. | &nbsp;&nbsp;&nbsp;&nbsp;421712 | &nbsp;&nbsp;&nbsp;&nbsp; 2505 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;AdaptHealth Corp. | &nbsp;&nbsp;&nbsp;&nbsp;274318 | &nbsp;&nbsp;&nbsp;&nbsp; 2463 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;agilon health Inc. | &nbsp;&nbsp;&nbsp;&nbsp;971716 | &nbsp;&nbsp;&nbsp;&nbsp; 2157 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Community Health Systems Inc. | &nbsp;&nbsp;&nbsp;&nbsp;394328 | &nbsp;&nbsp;&nbsp;&nbsp; 1530 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Owens & Minor Inc. | &nbsp;&nbsp;&nbsp;&nbsp;230355 | &nbsp;&nbsp;&nbsp;&nbsp; 1520 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Castle Biosciences Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;91087 | &nbsp;&nbsp;&nbsp;&nbsp; 1455 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;PACS Group Inc. | &nbsp;&nbsp;&nbsp;&nbsp;146594 | &nbsp;&nbsp;&nbsp;&nbsp; 1454 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Talkspace Inc. | &nbsp;&nbsp;&nbsp;&nbsp;447702 | &nbsp;&nbsp;&nbsp;&nbsp; 1428 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Enhabit Inc. | &nbsp;&nbsp;&nbsp;&nbsp;135247 | &nbsp;&nbsp;&nbsp;&nbsp; 1420 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;OPKO Health Inc. | &nbsp;&nbsp;&nbsp;&nbsp;943761 | &nbsp;&nbsp;&nbsp;&nbsp; 1284 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Fulgent Genetics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;61617 | &nbsp;&nbsp;&nbsp;&nbsp; 1277 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Cross Country Healthcare Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;91365 | &nbsp;&nbsp;&nbsp;&nbsp; 1204 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;DocGo Inc. | &nbsp;&nbsp;&nbsp;&nbsp;269710 | &nbsp;&nbsp;&nbsp;&nbsp; 383 |
| <sup>\*,1</sup> | &nbsp;&nbsp;&nbsp;ModivCare Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;22677 | &nbsp;&nbsp;&nbsp;&nbsp; 25 |
|  |  |  | &nbsp;&nbsp;&nbsp;&nbsp; **3252798** |
| **Health Care Technology (1.1%)** | **Health Care Technology (1.1%)** | **Health Care Technology (1.1%)** | **Health Care Technology (1.1%)** |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Veeva Systems Inc. Class A | &nbsp;&nbsp;&nbsp;&nbsp;483279 | &nbsp;&nbsp;&nbsp;&nbsp; 135173 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Doximity Inc. Class A | &nbsp;&nbsp;&nbsp;&nbsp;375570 | &nbsp;&nbsp;&nbsp;&nbsp; 19563 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Waystar Holding Corp. | &nbsp;&nbsp;&nbsp;&nbsp;215464 | &nbsp;&nbsp;&nbsp;&nbsp; 8614 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Certara Inc. | &nbsp;&nbsp;&nbsp;&nbsp;405083 | &nbsp;&nbsp;&nbsp;&nbsp; 4602 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Schrodinger Inc. | &nbsp;&nbsp;&nbsp;&nbsp;200671 | &nbsp;&nbsp;&nbsp;&nbsp; 4339 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Phreesia Inc. | &nbsp;&nbsp;&nbsp;&nbsp;175019 | &nbsp;&nbsp;&nbsp;&nbsp; 4286 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Teladoc Health Inc. | &nbsp;&nbsp;&nbsp;&nbsp;547153 | &nbsp;&nbsp;&nbsp;&nbsp; 3786 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Evolent Health Inc. Class A | &nbsp;&nbsp;&nbsp;&nbsp;311111 | &nbsp;&nbsp;&nbsp;&nbsp; 2318 |
|  | &nbsp;&nbsp;&nbsp;HealthStream Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;76629 | &nbsp;&nbsp;&nbsp;&nbsp; 2147 |
|  | &nbsp;&nbsp;&nbsp;Simulations Plus Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;53832 | &nbsp;&nbsp;&nbsp;&nbsp; 1714 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;GoodRx Holdings Inc. Class A | &nbsp;&nbsp;&nbsp;&nbsp;278991 | &nbsp;&nbsp;&nbsp;&nbsp; 1094 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Health Catalyst Inc. | &nbsp;&nbsp;&nbsp;&nbsp;200825 | &nbsp;&nbsp;&nbsp;&nbsp; 763 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Claritev Corp. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;15635 | &nbsp;&nbsp;&nbsp;&nbsp; 601 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Definitive Healthcare Corp. | &nbsp;&nbsp;&nbsp;&nbsp;146457 | &nbsp;&nbsp;&nbsp;&nbsp; 485 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;American Well Corp. Class A | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;39101 | &nbsp;&nbsp;&nbsp;&nbsp; 264 |
|  |  |  | &nbsp;&nbsp;&nbsp;&nbsp; **189749** |
| **Life Sciences Tools & Services (8.5%)** | **Life Sciences Tools & Services (8.5%)** | **Life Sciences Tools & Services (8.5%)** | **Life Sciences Tools & Services (8.5%)** |
|  | &nbsp;&nbsp;&nbsp;Thermo Fisher Scientific Inc. | 1180450 | &nbsp;&nbsp;&nbsp;&nbsp; 475509 |
|  | &nbsp;&nbsp;&nbsp;Danaher Corp. | 2013548 | &nbsp;&nbsp;&nbsp;&nbsp; 382373 |
|  | &nbsp;&nbsp;&nbsp;Agilent Technologies Inc. | &nbsp;&nbsp;&nbsp;&nbsp;891526 | &nbsp;&nbsp;&nbsp;&nbsp; 99780 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;IQVIA Holdings Inc. | &nbsp;&nbsp;&nbsp;&nbsp;551340 | &nbsp;&nbsp;&nbsp;&nbsp; 77370 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Mettler-Toledo International Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;65171 | &nbsp;&nbsp;&nbsp;&nbsp; 75306 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Waters Corp. | &nbsp;&nbsp;&nbsp;&nbsp;186049 | &nbsp;&nbsp;&nbsp;&nbsp; 64976 |

---

------

---

| | | | |
|:---|:---|:---|:---|
|  |  | Shares | &nbsp;&nbsp;&nbsp;&nbsp;Market<br> Value<br> ($000) |
|  | &nbsp;&nbsp;&nbsp;West Pharmaceutical Services Inc. | &nbsp;&nbsp;&nbsp;&nbsp;226064 | &nbsp;&nbsp;&nbsp;&nbsp; 47666 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Illumina Inc. | &nbsp;&nbsp;&nbsp;&nbsp;494896 | &nbsp;&nbsp;&nbsp;&nbsp; 40700 |
|  | &nbsp;&nbsp;&nbsp;Revvity Inc. | &nbsp;&nbsp;&nbsp;&nbsp;375713 | &nbsp;&nbsp;&nbsp;&nbsp; 33972 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Avantor Inc. | 1967347 | &nbsp;&nbsp;&nbsp;&nbsp; 25398 |
|  | &nbsp;&nbsp;&nbsp;Bio-Techne Corp. | &nbsp;&nbsp;&nbsp;&nbsp;494357 | &nbsp;&nbsp;&nbsp;&nbsp; 23927 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Medpace Holdings Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;80344 | &nbsp;&nbsp;&nbsp;&nbsp; 23693 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Charles River Laboratories International Inc. | &nbsp;&nbsp;&nbsp;&nbsp;153586 | &nbsp;&nbsp;&nbsp;&nbsp; 20831 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Repligen Corp. | &nbsp;&nbsp;&nbsp;&nbsp;166829 | &nbsp;&nbsp;&nbsp;&nbsp; 19698 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Bio-Rad Laboratories Inc. Class A | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;60969 | &nbsp;&nbsp;&nbsp;&nbsp; 13836 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Tempus AI Inc. | &nbsp;&nbsp;&nbsp;&nbsp;236567 | &nbsp;&nbsp;&nbsp;&nbsp; 13054 |
|  | &nbsp;&nbsp;&nbsp;Bruker Corp. | &nbsp;&nbsp;&nbsp;&nbsp;331347 | &nbsp;&nbsp;&nbsp;&nbsp; 12160 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Sotera Health Co. | &nbsp;&nbsp;&nbsp;&nbsp;490180 | &nbsp;&nbsp;&nbsp;&nbsp; 6000 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Azenta Inc. | &nbsp;&nbsp;&nbsp;&nbsp;129253 | &nbsp;&nbsp;&nbsp;&nbsp; 3454 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Adaptive Biotechnologies Corp. | &nbsp;&nbsp;&nbsp;&nbsp;324629 | &nbsp;&nbsp;&nbsp;&nbsp; 3090 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;10X Genomics Inc. Class A | &nbsp;&nbsp;&nbsp;&nbsp;307811 | &nbsp;&nbsp;&nbsp;&nbsp; 2933 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;BioLife Solutions Inc. | &nbsp;&nbsp;&nbsp;&nbsp;119292 | &nbsp;&nbsp;&nbsp;&nbsp; 2610 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Niagen Bioscience Inc. | &nbsp;&nbsp;&nbsp;&nbsp;170296 | &nbsp;&nbsp;&nbsp;&nbsp; 1843 |
|  | &nbsp;&nbsp;&nbsp;Mesa Laboratories Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;17070 | &nbsp;&nbsp;&nbsp;&nbsp; 1718 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Fortrea Holdings Inc. | &nbsp;&nbsp;&nbsp;&nbsp;268225 | &nbsp;&nbsp;&nbsp;&nbsp; 1153 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Cytek Biosciences Inc. | &nbsp;&nbsp;&nbsp;&nbsp;343829 | &nbsp;&nbsp;&nbsp;&nbsp; 952 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;CryoPort Inc. | &nbsp;&nbsp;&nbsp;&nbsp;155653 | &nbsp;&nbsp;&nbsp;&nbsp; 935 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Maravai LifeSciences Holdings Inc. Class A | &nbsp;&nbsp;&nbsp;&nbsp;357166 | &nbsp;&nbsp;&nbsp;&nbsp; 804 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Standard BioTools Inc. | &nbsp;&nbsp;&nbsp;&nbsp;769706 | &nbsp;&nbsp;&nbsp;&nbsp; 777 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;MaxCyte Inc. | &nbsp;&nbsp;&nbsp;&nbsp;313574 | &nbsp;&nbsp;&nbsp;&nbsp; 746 |
| <sup>\*,1</sup> | &nbsp;&nbsp;&nbsp;Pacific Biosciences of California Inc. | &nbsp;&nbsp;&nbsp;&nbsp;771703 | &nbsp;&nbsp;&nbsp;&nbsp; 744 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Quanterix Corp. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;96926 | &nbsp;&nbsp;&nbsp;&nbsp; 504 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;OmniAb Inc. | &nbsp;&nbsp;&nbsp;&nbsp;273390 | &nbsp;&nbsp;&nbsp;&nbsp; 347 |
| <sup>\*,2</sup> | &nbsp;&nbsp;&nbsp;OmniAb Inc. 12.5 Earnout | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;22076 | &nbsp;&nbsp;&nbsp;&nbsp; — |
| <sup>\*,2</sup> | &nbsp;&nbsp;&nbsp;OmniAb Inc. 15 Earnout | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;22076 | &nbsp;&nbsp;&nbsp;&nbsp; — |
|  |  |  | &nbsp;&nbsp;&nbsp;&nbsp; **1478859** |
| **Pharmaceuticals (25.8%)** | **Pharmaceuticals (25.8%)** | **Pharmaceuticals (25.8%)** | **Pharmaceuticals (25.8%)** |
|  | &nbsp;&nbsp;&nbsp;Eli Lilly & Co. | 2519803 | &nbsp;&nbsp;&nbsp;&nbsp; 1858783 |
|  | &nbsp;&nbsp;&nbsp;Johnson & Johnson | 5285882 | &nbsp;&nbsp;&nbsp;&nbsp; 820422 |
|  | &nbsp;&nbsp;&nbsp;Merck & Co. Inc. | 7869026 | &nbsp;&nbsp;&nbsp;&nbsp; 604656 |
|  | &nbsp;&nbsp;&nbsp;Pfizer Inc. | 17735422 | &nbsp;&nbsp;&nbsp;&nbsp; 416605 |
|  | &nbsp;&nbsp;&nbsp;Bristol-Myers Squibb Co. | 6362961 | &nbsp;&nbsp;&nbsp;&nbsp; 307204 |
|  | &nbsp;&nbsp;&nbsp;Zoetis Inc. | 1394868 | &nbsp;&nbsp;&nbsp;&nbsp; 235217 |
|  | &nbsp;&nbsp;&nbsp;Royalty Pharma plc Class A | 1152098 | &nbsp;&nbsp;&nbsp;&nbsp; 37881 |
|  | &nbsp;&nbsp;&nbsp;Viatris Inc. | 3734060 | &nbsp;&nbsp;&nbsp;&nbsp; 32822 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Corcept Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;296931 | &nbsp;&nbsp;&nbsp;&nbsp; 23030 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Elanco Animal Health Inc. (XNYS) | 1552461 | &nbsp;&nbsp;&nbsp;&nbsp; 20865 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Jazz Pharmaceuticals plc | &nbsp;&nbsp;&nbsp;&nbsp;180476 | &nbsp;&nbsp;&nbsp;&nbsp; 19504 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Prestige Consumer Healthcare Inc. | &nbsp;&nbsp;&nbsp;&nbsp;154926 | &nbsp;&nbsp;&nbsp;&nbsp; 13273 |
|  | &nbsp;&nbsp;&nbsp;Perrigo Co. plc | &nbsp;&nbsp;&nbsp;&nbsp;426793 | &nbsp;&nbsp;&nbsp;&nbsp; 11425 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Axsome Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;106747 | &nbsp;&nbsp;&nbsp;&nbsp; 11226 |
|  | &nbsp;&nbsp;&nbsp;Organon & Co. | &nbsp;&nbsp;&nbsp;&nbsp;805846 | &nbsp;&nbsp;&nbsp;&nbsp; 7430 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Ligand Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;60186 | &nbsp;&nbsp;&nbsp;&nbsp; 6150 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Supernus Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;175005 | &nbsp;&nbsp;&nbsp;&nbsp; 5548 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Harmony Biosciences Holdings Inc. | &nbsp;&nbsp;&nbsp;&nbsp;134401 | &nbsp;&nbsp;&nbsp;&nbsp; 4637 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Tarsus Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;104076 | &nbsp;&nbsp;&nbsp;&nbsp; 4470 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Pacira BioSciences Inc. | &nbsp;&nbsp;&nbsp;&nbsp;144813 | &nbsp;&nbsp;&nbsp;&nbsp; 3742 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Innoviva Inc. | &nbsp;&nbsp;&nbsp;&nbsp;186259 | &nbsp;&nbsp;&nbsp;&nbsp; 3645 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Amneal Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;489727 | &nbsp;&nbsp;&nbsp;&nbsp; 3585 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;ANI Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;53955 | &nbsp;&nbsp;&nbsp;&nbsp; 3168 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Amphastar Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;118777 | &nbsp;&nbsp;&nbsp;&nbsp; 3054 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Liquidia Corp. | &nbsp;&nbsp;&nbsp;&nbsp;200041 | &nbsp;&nbsp;&nbsp;&nbsp; 2985 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Collegium Pharmaceutical Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;99570 | &nbsp;&nbsp;&nbsp;&nbsp; 2901 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Harrow Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;98426 | &nbsp;&nbsp;&nbsp;&nbsp; 2767 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Ocular Therapeutix Inc. | &nbsp;&nbsp;&nbsp;&nbsp;323200 | &nbsp;&nbsp;&nbsp;&nbsp; 2589 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Avadel Pharmaceuticals plc | &nbsp;&nbsp;&nbsp;&nbsp;272373 | &nbsp;&nbsp;&nbsp;&nbsp; 2481 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Xeris Biopharma Holdings Inc. | &nbsp;&nbsp;&nbsp;&nbsp;457651 | &nbsp;&nbsp;&nbsp;&nbsp; 2261 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Edgewise Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;147567 | &nbsp;&nbsp;&nbsp;&nbsp; 2107 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;WaVe Life Sciences Ltd. | &nbsp;&nbsp;&nbsp;&nbsp;335909 | &nbsp;&nbsp;&nbsp;&nbsp; 2019 |
|  | &nbsp;&nbsp;&nbsp;Phibro Animal Health Corp. Class A | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;64365 | &nbsp;&nbsp;&nbsp;&nbsp; 1572 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Nuvation Bio Inc. | &nbsp;&nbsp;&nbsp;&nbsp;682262 | &nbsp;&nbsp;&nbsp;&nbsp; 1446 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Evolus Inc. | &nbsp;&nbsp;&nbsp;&nbsp;148829 | &nbsp;&nbsp;&nbsp;&nbsp; 1368 |
| <sup>\*,1</sup> | &nbsp;&nbsp;&nbsp;Mind Medicine MindMed Inc. | &nbsp;&nbsp;&nbsp;&nbsp;188488 | &nbsp;&nbsp;&nbsp;&nbsp; 1368 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Enliven Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;76531 | &nbsp;&nbsp;&nbsp;&nbsp; 1360 |
| <sup>\*,1</sup> | &nbsp;&nbsp;&nbsp;Tilray Brands Inc. | 3154251 | &nbsp;&nbsp;&nbsp;&nbsp; 1343 |

---

------

---

| | | | |
|:---|:---|:---|:---|
|  |  | Shares | &nbsp;&nbsp;&nbsp;&nbsp;Market<br> Value<br> ($000) |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;EyePoint Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;183058 | &nbsp;&nbsp;&nbsp;&nbsp; 1325 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Arvinas Inc. | &nbsp;&nbsp;&nbsp;&nbsp;151465 | &nbsp;&nbsp;&nbsp;&nbsp; 1091 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Theravance Biopharma Inc. | &nbsp;&nbsp;&nbsp;&nbsp;118581 | &nbsp;&nbsp;&nbsp;&nbsp; 1086 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Amylyx Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;198018 | &nbsp;&nbsp;&nbsp;&nbsp; 1020 |
| <sup>\*,1</sup> | &nbsp;&nbsp;&nbsp;ATAI Life Sciences NV | &nbsp;&nbsp;&nbsp;&nbsp;437085 | &nbsp;&nbsp;&nbsp;&nbsp; 1010 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;LENZ Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;34445 | &nbsp;&nbsp;&nbsp;&nbsp; 1006 |
|  | &nbsp;&nbsp;&nbsp;SIGA Technologies Inc. | &nbsp;&nbsp;&nbsp;&nbsp;135372 | &nbsp;&nbsp;&nbsp;&nbsp; 810 |
| <sup>\*,1</sup> | &nbsp;&nbsp;&nbsp;Phathom Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;130611 | &nbsp;&nbsp;&nbsp;&nbsp; 555 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Terns Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;177224 | &nbsp;&nbsp;&nbsp;&nbsp; 551 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Atea Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;167431 | &nbsp;&nbsp;&nbsp;&nbsp; 497 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Rapport Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;51780 | &nbsp;&nbsp;&nbsp;&nbsp; 428 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Alumis Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;90095 | &nbsp;&nbsp;&nbsp;&nbsp; 315 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Cassava Sciences Inc. | &nbsp;&nbsp;&nbsp;&nbsp;142926 | &nbsp;&nbsp;&nbsp;&nbsp; 287 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Ventyx Biosciences Inc. | &nbsp;&nbsp;&nbsp;&nbsp;156531 | &nbsp;&nbsp;&nbsp;&nbsp; 266 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Pliant Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;115910 | &nbsp;&nbsp;&nbsp;&nbsp; 156 |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Neumora Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;176184 | &nbsp;&nbsp;&nbsp;&nbsp; 126 |
| <sup>\*,2</sup> | &nbsp;&nbsp;&nbsp;Chinook Therapeutics Inc. CVR | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;784 | &nbsp;&nbsp;&nbsp;&nbsp; — |
|  |  |  | &nbsp;&nbsp;&nbsp;&nbsp; **4497438** |
| **Total Common Stocks (Cost $14,891,952)** | **Total Common Stocks (Cost $14,891,952)** | **Total Common Stocks (Cost $14,891,952)** | &nbsp;&nbsp;&nbsp;&nbsp;**16902477** |
| **Temporary Cash Investments (3.1%)** | **Temporary Cash Investments (3.1%)** | **Temporary Cash Investments (3.1%)** | **Temporary Cash Investments (3.1%)** |
| **Money Market Fund (3.1%)** | **Money Market Fund (3.1%)** | **Money Market Fund (3.1%)** | **Money Market Fund (3.1%)** |
| <sup>3,4</sup> | &nbsp;&nbsp;&nbsp;Vanguard Market Liquidity Fund, 4.342% **(Cost $532,096)** | 5321583 | &nbsp;&nbsp;&nbsp;&nbsp; **532105** |
| **Total Investments (100.1%) (Cost $15,424,048)** | **Total Investments (100.1%) (Cost $15,424,048)** | **Total Investments (100.1%) (Cost $15,424,048)** | &nbsp;&nbsp;&nbsp;&nbsp;**17434582** |
| **Common Stocks Sold Short (-0.0%)** | **Common Stocks Sold Short (-0.0%)** | **Common Stocks Sold Short (-0.0%)** | **Common Stocks Sold Short (-0.0%)** |
| **Biotechnology (-0.0%)** | **Biotechnology (-0.0%)** | **Biotechnology (-0.0%)** | **Biotechnology (-0.0%)** |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Enanta Pharmaceuticals Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(22) | &nbsp;&nbsp;&nbsp;&nbsp; (—) |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Repare Therapeutics Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(21) | &nbsp;&nbsp;&nbsp;&nbsp; (—) |
|  |  |  | &nbsp;&nbsp;&nbsp;&nbsp; **(—)** |
| **Health Care Equipment & Supplies (-0.0%)** | **Health Care Equipment & Supplies (-0.0%)** | **Health Care Equipment & Supplies (-0.0%)** | **Health Care Equipment & Supplies (-0.0%)** |
| <sup>\*</sup> | &nbsp;&nbsp;&nbsp;Outset Medical Inc. | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(4) | &nbsp;&nbsp;&nbsp;&nbsp; (—) |
| **Total Common Stocks Sold Short (Proceeds $—)** | **Total Common Stocks Sold Short (Proceeds $—)** | **Total Common Stocks Sold Short (Proceeds $—)** | &nbsp;&nbsp;&nbsp;&nbsp;**(—)** |
| **Other Assets and Liabilities—Net (-0.1%)** | **Other Assets and Liabilities—Net (-0.1%)** | **Other Assets and Liabilities—Net (-0.1%)** | &nbsp;&nbsp;&nbsp;&nbsp;**(15455)** |
| **Net Assets (100.0%)** | **Net Assets (100.0%)** | **Net Assets (100.0%)** | &nbsp;&nbsp;&nbsp;&nbsp;**17419127** |
| Cost is in $000. | Cost is in $000. | Cost is in $000. | Cost is in $000. |

---

---

| | |
|:---|:---|
| \* | Non-income-producing security. |
| 1 | Includes partial security positions on loan to broker-dealers. The total value of securities on loan is $30,221. |
| 2 | Security value determined using significant unobservable inputs. |
| 3 | Affiliated money market fund available only to Vanguard funds and certain trusts and accounts managed by Vanguard. Rate shown is the 7-day yield. |
| 4 | Collateral of $43,123 was received for securities on loan. |

---

CVR—Contingent Value Rights.

------

#### Derivative Financial Instruments Outstanding as of Period End

------

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| Over-the-Counter Total Return Swaps | Over-the-Counter Total Return Swaps | Over-the-Counter Total Return Swaps | Over-the-Counter Total Return Swaps | Over-the-Counter Total Return Swaps | Over-the-Counter Total Return Swaps | Over-the-Counter Total Return Swaps |
| Reference Entity | Termination<br> Date | &nbsp;&nbsp;&nbsp;Counterparty | &nbsp;&nbsp;&nbsp;Notional<br> Amount<br> ($000) | &nbsp;&nbsp;&nbsp;Floating<br> Interest Rate<br> Received<br> (Paid)<sup>1</sup><br> (%) | &nbsp;&nbsp;&nbsp;Value and<br> Unrealized<br> Appreciation<br> ($000) | &nbsp;&nbsp;&nbsp;Value and<br> Unrealized<br> (Depreciation)<br> ($000) |
| AbbVie Inc. | 8/29/25 | &nbsp;&nbsp;&nbsp;BANA | &nbsp;&nbsp;&nbsp;102361 | &nbsp;&nbsp;&nbsp;(5.037) | &nbsp;&nbsp;&nbsp;452 | &nbsp;&nbsp;&nbsp;— |
| AbbVie Inc. | 8/29/25 | &nbsp;&nbsp;&nbsp;BANA | &nbsp;&nbsp;&nbsp;55833 | &nbsp;&nbsp;&nbsp;(5.037) | &nbsp;&nbsp;&nbsp;246 | &nbsp;&nbsp;&nbsp;— |
| Avantor Inc. | 8/29/25 | &nbsp;&nbsp;&nbsp;BANA | &nbsp;&nbsp;&nbsp;2091 | &nbsp;&nbsp;&nbsp;(4.337) | &nbsp;&nbsp;&nbsp;— | &nbsp;&nbsp;&nbsp;(7) |
| Globus Medical Inc. | 8/29/25 | &nbsp;&nbsp;&nbsp;BANA | &nbsp;&nbsp;&nbsp;5918 | &nbsp;&nbsp;&nbsp;(4.337) | &nbsp;&nbsp;&nbsp;— | &nbsp;&nbsp;&nbsp;(26) |
| Johnson & Johnson | 8/29/25 | &nbsp;&nbsp;&nbsp;BANA | &nbsp;&nbsp;&nbsp;131929 | &nbsp;&nbsp;&nbsp;(5.080) | &nbsp;&nbsp;&nbsp;1086 | &nbsp;&nbsp;&nbsp;— |
| Johnson & Johnson | 8/29/25 | &nbsp;&nbsp;&nbsp;BANA | &nbsp;&nbsp;&nbsp;131929 | &nbsp;&nbsp;&nbsp;(5.080) | &nbsp;&nbsp;&nbsp;1086 | &nbsp;&nbsp;&nbsp;— |
| Johnson & Johnson | 8/29/25 | &nbsp;&nbsp;&nbsp;BANA | &nbsp;&nbsp;&nbsp;46563 | &nbsp;&nbsp;&nbsp;(4.987) | &nbsp;&nbsp;&nbsp;195 | &nbsp;&nbsp;&nbsp;— |
| Johnson & Johnson | 8/29/25 | &nbsp;&nbsp;&nbsp;BANA | &nbsp;&nbsp;&nbsp;23282 | &nbsp;&nbsp;&nbsp;(5.087) | &nbsp;&nbsp;&nbsp;96 | &nbsp;&nbsp;&nbsp;— |

---

------

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| Over-the-Counter Total Return Swaps (continued) | Over-the-Counter Total Return Swaps (continued) | Over-the-Counter Total Return Swaps (continued) | Over-the-Counter Total Return Swaps (continued) | Over-the-Counter Total Return Swaps (continued) | Over-the-Counter Total Return Swaps (continued) | Over-the-Counter Total Return Swaps (continued) |
| Reference Entity | Termination<br> Date | &nbsp;&nbsp;&nbsp;Counterparty | &nbsp;&nbsp;&nbsp;Notional<br> Amount<br> ($000) | &nbsp;&nbsp;&nbsp;Floating<br> Interest Rate<br> Received<br> (Paid)<sup>1</sup><br> (%) | &nbsp;&nbsp;&nbsp;Value and<br> Unrealized<br> Appreciation<br> ($000) | &nbsp;&nbsp;&nbsp;Value and<br> Unrealized<br> (Depreciation)<br> ($000) |
| Johnson & Johnson | 1/30/26 | &nbsp;&nbsp;&nbsp;GSI | &nbsp;&nbsp;&nbsp;14961 | &nbsp;&nbsp;&nbsp;(4.333) | &nbsp;&nbsp;&nbsp;663 | &nbsp;&nbsp;&nbsp;— |
| Sarepta Therapeutics Inc. | 8/29/25 | &nbsp;&nbsp;&nbsp;BANA | &nbsp;&nbsp;&nbsp;2444 | &nbsp;&nbsp;&nbsp;(4.337) | &nbsp;&nbsp;&nbsp;— | &nbsp;&nbsp;&nbsp;(15) |
|  |  |  |  |  | &nbsp;&nbsp;&nbsp;3824 | &nbsp;&nbsp;&nbsp;(48) |

---

1 Based on Overnight Bank Funding Rate as of the most recent reset date. Floating interest payment received/paid monthly. <br> BANA—Bank of America, N.A. <br> GSI—Goldman Sachs International.

At May 31, 2025, the counterparties had deposited in segregated accounts securities with a value of $502 in connection with open over-the-counter swap contracts.

**A.** Security Valuation: Securities are valued as of the close of trading on the New York Stock Exchange (generally 4 p.m., Eastern time) on the valuation date. Equity securities are valued at the latest quoted sales
prices or official closing prices taken from the primary market in which each security trades; such securities not traded on the valuation date are valued at the mean of the latest quoted bid and asked prices.
Securities for which market quotations are not readily available, or whose values have been affected by events occurring before the fund's pricing time but after the close of the securities' primary
markets, are valued by methods deemed by the valuation designee to represent fair value and subject to oversight by the board of trustees. Investments in Vanguard Market Liquidity Fund are valued at that fund's net
asset value.

**B.** Short Sales: Short sales are the sales of securities that the fund does not own. The fund sells a security it does not own in anticipation of a decline in the value of that security. In order to deliver the security
to the purchaser, the fund borrows the security from a broker-dealer. The fund must segregate, as collateral for its obligation to return the borrowed security, an amount of cash and long security positions at least
equal to the market value of the security sold short. In the absence of a default, the collateral segregated by the fund cannot be repledged, resold or rehypothecated. This results in the fund holding a significant
portion of its assets in cash. The fund later closes out the position by returning the security to the lender, typically by purchasing the security in the open market.

**C.** Swap Contracts: The fund has entered into equity swap contracts to earn the total return on selected reference stocks or indexes in the fund's target index. Under the terms of
the swaps, the fund receives the total return on the referenced stock (i.e., receiving the increase or paying the decrease in value of the selected reference stock and receiving the equivalent of any dividends in
respect of the selected referenced stock) over a specified period of time, applied to a notional amount that represents the value of a designated number of shares of the selected reference stock at the beginning of
the equity swap contract. The fund also pays a floating rate that is based on short-term interest rates, applied to the notional amount. At the same time, the fund generally invests an amount approximating the
notional amount of the swap in high-quality temporary cash investments.

A risk associated with all types of swaps is the possibility that a counterparty may default on its obligation to pay net amounts due to the fund. The fund's maximum amount subject to counterparty risk is the unrealized appreciation on the swap contract. The fund mitigates its counterparty risk by entering into swaps only with a diverse group of prequalified counterparties, monitoring their financial strength, entering into master netting arrangements with its counterparties, and requiring its counterparties to transfer collateral as security for their performance. In the absence of a default, the collateral pledged or received by the fund cannot be repledged, resold, or rehypothecated. In the event of a counterparty's default (including bankruptcy), the fund may terminate any swap contracts with that counterparty, determine the net amount owed by either party in accordance with its master netting arrangements, and sell or retain any collateral held up to the net amount owed to the fund under the master netting arrangements. The swap contracts contain provisions whereby a counterparty may terminate open contracts if the fund's net assets decline below a certain level, triggering a payment by the fund if the fund is in a net liability position at the time of the termination. The payment amount would be reduced by any collateral the fund has pledged. Any securities pledged as collateral for open contracts are noted in the Schedule of Investments. The value of collateral received or pledged is compared daily to the value of the swap contracts exposure with each counterparty, and any difference, if in excess of a specified minimum transfer amount, is adjusted and settled within two business days.

Swaps are valued daily based on market quotations received from independent pricing services or recognized dealers and the change in value is recorded as an asset (liability) and as unrealized appreciation (depreciation) until periodic payments are made or the termination of the swap, at which time realized gain (loss) is recorded.

**D.** Various inputs may be used to determine the value of the fund's investments and derivatives. These inputs are summarized in three broad levels for financial statement purposes. The inputs or methodologies used
to value securities are not necessarily an indication of the risk associated with investing in those securities.

#### Level 1 —Quoted prices in active markets for identical securities.

#### Level 2 —Other significant observable inputs (including quoted prices for similar securities, interest rates, prepayment speeds, credit risk, etc.).
**Level 3—Significant unobservable inputs (including the fund's own assumptions used to determine the fair value of investments). Any investments and derivatives valued with significant unobservable inputs are noted on the Schedule of Investments.**

------

The following table summarizes the market value of the fund's investments and derivatives as of May 31, 2025, based on the inputs used to value them:

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | Level 1<br> ($000) | &nbsp;&nbsp;&nbsp;Level 2<br> ($000) | &nbsp;&nbsp;&nbsp;Level 3<br> ($000) | &nbsp;&nbsp;&nbsp;Total<br> ($000) |
| **Investments** |  |  |  |  |
| Assets |  |  |  |  |
| Common Stocks | 16902477 | &nbsp;&nbsp;&nbsp;— | &nbsp;&nbsp;&nbsp;— | &nbsp;&nbsp;&nbsp;16902477 |
| Temporary Cash Investments | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;532105 | &nbsp;&nbsp;&nbsp;— | &nbsp;&nbsp;&nbsp;— | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;532105 |
| Total | 17434582 | &nbsp;&nbsp;&nbsp;— | &nbsp;&nbsp;&nbsp;— | &nbsp;&nbsp;&nbsp;17434582 |
| Liabilities |  |  |  |  |
| Common Stocks | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— | &nbsp;&nbsp;&nbsp;— | &nbsp;&nbsp;&nbsp;— | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;— |
| **Derivative Financial Instruments** |  |  |  |  |
| Assets |  |  |  |  |
| Swap Contracts |  | &nbsp;&nbsp;&nbsp;3824 | &nbsp;&nbsp;&nbsp;— | &nbsp;&nbsp;&nbsp;3824 |
| Liabilities |  |  |  |  |
| Swap Contracts |  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(48) | &nbsp;&nbsp;&nbsp;— | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(48) |

---

## Form NPORT-P: Monthly Portfolio Investments Report

### NPORT-P: Part A: General Information

**Item A.1. Information about the Registrant.**

- **a. Name of Registrant:** VANGUARD WORLD FUND

- **b. Investment Company Act file number:** 811-01027

- **c. CIK number of Registrant:** 0000052848

- **d. LEI of Registrant:** 549300MP6BT0L4Q61L10

- **e. Address and telephone number of Registrant.**

  - **Street Address 1:** 100 Vanguard Boulevard

  - **City:** Malvern

  - **State:** PA

  - **Foreign country:** US

  - **Zip / Postal Code:** 19355

  - **Telephone number:** 610-669-1000

**Item A.2. Information about the Series.**

- **a. Name of Series:** VANGUARD HEALTH CARE INDEX FUND

- **b. EDGAR series identifier (if any):** S000004450

- **c. LEI of Series:** 4G9X037GNB6OUK17TK21

**Item A.3. Reporting period.**

- **a. Date of fiscal year-end:** 2025-08-31

- **b. Date as of which information is reported:** 2025-05-31

**Item A.4. Final filing**

Does the Fund anticipate that this will be its final filing on Form N-PORT? **No**

### Fund Information

**Total Assets:** $17463704588.73

**Total Liabilities:** $19828673.26

**Net Assets:** $17443875915.47

**Cash Not Reported:** $16014358.88

**Monthly Return Information**

| Class               | Month 1 Return (%)   | Month 2 Return (%)   | Month 3 Return (%)   |
|:---|:---|:---|:---|
| Class ID C000012223 | -2.29%               | -3.27%               | -4.82%               |
| Class ID C000012222 | -2.29%               | -3.27%               | -4.81%               |

**Monthly Gains & Losses**

| Period   | Net Realized Gain/Loss   | Net Unrealized Appreciation/Depreciation   |
|:---|:---|:---|
| Month 1  | $2330237.77              | $-543582551.42                             |
| Month 2  | $120186343.96            | $-745002905.33                             |
| Month 3  | $66147013.03             | $-916968582.47                             |

### Schedule of Portfolio Investments

| Name                                              | Title                                            | Identifiers                                   | Payoff Profile   | Asset Category   | Issuer Category   | Country   |   Balance | Units   | Value (USD)    | % of Net Assets   | Maturity Date   | Coupon Type   | Annualized Rate (%)   | Restricted?   |   Fair Value Level | Lending Status   |
|:---|:---|:---|:---|:---|:---|:---|---:|:---|:---|:---|:---|:---|:---|:---|---:|:---|
| Surgery Partners Inc                              | SURGERY PARTNERS                                 | CUSIP: 86881A100<br>LEI: 549300LC82HG33S19I03 | Long             | EC               | CORP              | US        |    218210 | NS      | $5151938.10    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Varex Imaging Corp                                | VAREX IMAGIN                                     | CUSIP: 92214X106<br>LEI: 549300CWYWPVCT8E9W67 | Long             | EC               | CORP              | US        |    128347 | NS      | $984421.49     | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Prevail Therapeutics Inc                          | PREVAIL THERAPEU - CVR                           | CUSIP: N/A<br>LEI: N/A                        | Long             | EC               | CORP              | US        |        78 | NS      | $39.00         | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Disc Medicine Inc                                 | DISC MEDICINE IN                                 | CUSIP: 254604101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     58148 | NS      | $2714348.64    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                               | Receive JOHNSON&JOHNSON Pay Overnight Rate +0.65 | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | N/A       |    300000 | NC      | $-329997.00    | -0.00%            |  |  |  | No            |                  2 | On Loan: No      |
| Alumis Inc                                        | ALUMIS INC                                       | CUSIP: 022307102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     90126 | NS      | $315441.00     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Hologic Inc                                       | HOLOGIC INC                                      | CUSIP: 436440101<br>LEI: 549300DYP6F5ZJL0LB74 | Long             | EC               | CORP              | US        |    710789 | NS      | $44189752.13   | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| CG oncology Inc                                   | CG ONCOLOGY INC                                  | CUSIP: 156944100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    131617 | NS      | $3372027.54    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Chemed Corp                                       | CHEMED CORP                                      | CUSIP: 16359R103<br>LEI: 54930020031IDJT2IM79 | Long             | EC               | CORP              | US        |     44615 | NS      | $25646486.60   | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Embecta Corp                                      | EMBECTA CORP                                     | CUSIP: 29082K105<br>LEI: 549300RPG8GXVDHNXZ62 | Long             | EC               | CORP              | US        |    172675 | NS      | $1818267.75    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Terns Pharmaceuticals Inc                         | TERNS PHARMACEUT                                 | CUSIP: 880881107<br>LEI: 254900S1ZDQMF4MYP709 | Long             | EC               | CORP              | US        |    159354 | NS      | $495590.94     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Thermo Fisher Scientific Inc                      | THERMO FISHER                                    | CUSIP: 883556102<br>LEI: HCHV7422L5HDJZCRFL38 | Long             | EC               | CORP              | US        |   1198452 | NS      | $482760434.64  | 2.77%             |  |  |  | No            |                  1 | On Loan: No      |
| Olema Pharmaceuticals Inc                         | OLEMA PHARMACEUT                                 | CUSIP: 68062P106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    106308 | NS      | $561306.24     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Penumbra Inc                                      | PENUMBRA INC                                     | CUSIP: 70975L107<br>LEI: 549300RGE06P3ECANU72 | Long             | EC               | CORP              | US        |    114158 | NS      | $30476761.26   | 0.17%             |  |  |  | No            |                  1 | On Loan: No      |
| Avantor Inc                                       | AVANTOR INC                                      | CUSIP: 05352A100<br>LEI: 5493003VM0XB4U8YD238 | Long             | EC               | CORP              | US        |   1971929 | NS      | $25457603.39   | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Anavex Life Sciences Corp                         | ANAVEX LIFE SCIE                                 | CUSIP: 032797300<br>LEI: 549300K1I5L8COCQ8W36 | Long             | EC               | CORP              | US        |    263806 | NS      | $1986459.18    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Exelixis Inc                                      | EXELIXIS INC                                     | CUSIP: 30161Q104<br>LEI: 254900PJQB59O2O95R37 | Long             | EC               | CORP              | US        |    804556 | NS      | $34628090.24   | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Mind Medicine MindMed Inc                         | MIND MEDICINE MI                                 | CUSIP: 60255C885<br>LEI: 549300QY8KN1O6RPFJ13 | Long             | EC               | CORP              | US        |    172994 | NS      | $1255936.44    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Option Care Health Inc                            | OPTION CARE HEAL                                 | CUSIP: 68404L201<br>LEI: 549300DI3Q5ACSYJRI17 | Long             | EC               | CORP              | US        |    532888 | NS      | $17414779.84   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| GE HealthCare Technologies Inc                    | GE HEALTHCARE TE                                 | CUSIP: 36266G107<br>LEI: 549300OI9J7XOWZMUN85 | Long             | EC               | CORP              | US        |   1431500 | NS      | $100978010.00  | 0.58%             |  |  |  | No            |                  1 | On Loan: No      |
| Zimmer Biomet Holdings Inc                        | ZIMMER BIOMET HO                                 | CUSIP: 98956P102<br>LEI: 2P2YLDVPES3BXQ1FRB91 | Long             | EC               | CORP              | US        |    623708 | NS      | $57487166.36   | 0.33%             |  |  |  | No            |                  1 | On Loan: No      |
| Kiniksa Pharmaceuticals International Plc         | KINIKSA PHARMACE                                 | CUSIP: G52694109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    117748 | NS      | $3221585.28    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Medtronic PLC                                     | MEDTRONIC PLC                                    | CUSIP: G5960L103<br>LEI: 549300GX3ZBSQWUXY261 | Long             | EC               | CORP              | US        |   4018089 | NS      | $333421025.22  | 1.91%             |  |  |  | No            |                  1 | On Loan: No      |
| Prime Medicine Inc                                | PRIME MEDICINE I                                 | CUSIP: 74168J101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    127103 | NS      | $149981.54     | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| Outset Medical Inc                                | OUTSET MEDICAL I                                 | CUSIP: 690145206<br>LEI: N/A                  | Long             | EC               | CORP              | US        |      9942 | NS      | $174680.94     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Amicus Therapeutics Inc                           | AMICUS THERAPEUT                                 | CUSIP: 03152W109<br>LEI: 549300MRD1SMUTNBPQ53 | Long             | EC               | CORP              | US        |    699647 | NS      | $4246857.29    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Health Catalyst Inc                               | HEALTH CATALYST                                  | CUSIP: 42225T107<br>LEI: 549300223PL6GWKVJG92 | Long             | EC               | CORP              | US        |    187305 | NS      | $711759.00     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Keros Therapeutics Inc                            | KEROS THERAPEUTI                                 | CUSIP: 492327101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    102137 | NS      | $1445238.55    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Align Technology Inc                              | ALIGN TECHNOLOGY                                 | CUSIP: 016255101<br>LEI: 549300N5YSE0U3LCP840 | Long             | EC               | CORP              | US        |    222075 | NS      | $40182250.50   | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Phibro Animal Health Corp                         | PHIBRO ANIMAL-A                                  | CUSIP: 71742Q106<br>LEI: 549300U24SP4AF2JUX52 | Long             | EC               | CORP              | US        |     64387 | NS      | $1572330.54    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Progyny Inc                                       | PROGYNY INC                                      | CUSIP: 74340E103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    227486 | NS      | $4890949.00    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Simulations Plus Inc                              | SIMULATIONS PLUS                                 | CUSIP: 829214105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     53851 | NS      | $1714885.10    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Haemonetics Corp                                  | HAEMONETICS CORP                                 | CUSIP: 405024100<br>LEI: 549300ZEL6TXZS6F5F95 | Long             | EC               | CORP              | US        |    157064 | NS      | $10634803.44   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| American Well Corp                                | AMERICAN WELL -A                                 | CUSIP: 03044L204<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     39115 | NS      | $263635.10     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Quest Diagnostics Inc                             | QUEST DIAGNOSTIC                                 | CUSIP: 74834L100<br>LEI: 8MCWUBXQ0WE04KMXBX50 | Long             | EC               | CORP              | US        |    349643 | NS      | $60607117.62   | 0.35%             |  |  |  | No            |                  1 | On Loan: No      |
| Innoviva Inc                                      | INNOVIVA INC                                     | CUSIP: 45781M101<br>LEI: 549300ACOX4QTBES6535 | Long             | EC               | CORP              | US        |    176850 | NS      | $3460954.50    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Celldex Therapeutics Inc                          | CELLDEX THERAPEU                                 | CUSIP: 15117B202<br>LEI: 529900F018DMYWH38923 | Long             | EC               | CORP              | US        |    187761 | NS      | $3713912.58    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Pediatrix Medical Group Inc                       | PEDIATRIX MEDICA                                 | CUSIP: 58502B106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    270230 | NS      | $3823754.50    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| BioCryst Pharmaceuticals Inc                      | BIOCRYST PHARM                                   | CUSIP: 09058V103<br>LEI: 549300Z0INP1Z5NP6J59 | Long             | EC               | CORP              | US        |    618698 | NS      | $6651003.50    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Envista Holdings Corp                             | ENVISTA HOLDINGS                                 | CUSIP: 29415F104<br>LEI: 549300BX623VURJZ5269 | Long             | EC               | CORP              | US        |    538063 | NS      | $9830411.01    | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Prothena Corp PLC                                 | PROTHENA CORP PL                                 | CUSIP: G72800108<br>LEI: 5299009ZXQ8NIIJ8OL30 | Long             | EC               | CORP              | US        |    110431 | NS      | $506878.29     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| United Therapeutics Corp                          | UNITED THERAPEUT                                 | CUSIP: 91307C102<br>LEI: 5299005C4HZL4UWROC14 | Long             | EC               | CORP              | US        |    132801 | NS      | $42343598.85   | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Savara Inc                                        | SAVARA INC                                       | CUSIP: 805111101<br>LEI: 5493002JO0WM3YMJXG33 | Long             | EC               | CORP              | US        |    286457 | NS      | $653121.96     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Amgen Inc                                         | AMGEN INC                                        | CUSIP: 031162100<br>LEI: 62QBXGPJ34PQ72Z12S66 | Long             | EC               | CORP              | US        |   1684169 | NS      | $485343822.42  | 2.78%             |  |  |  | No            |                  1 | On Loan: No      |
| Halozyme Therapeutics Inc                         | HALOZYME THERAPE                                 | CUSIP: 40637H109<br>LEI: 529900242I3SV9AGM753 | Long             | EC               | CORP              | US        |    398977 | NS      | $22370640.39   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Sage Therapeutics Inc                             | SAGE THERAPEUTIC                                 | CUSIP: 78667J108<br>LEI: 5493000JX4BJS9W6CN35 | Long             | EC               | CORP              | US        |    142940 | NS      | $923392.40     | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Perrigo Co PLC                                    | PERRIGO CO PLC                                   | CUSIP: G97822103<br>LEI: 549300IFOQS6R1QLY196 | Long             | EC               | CORP              | US        |    426942 | NS      | $11429237.34   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Axsome Therapeutics Inc                           | AXSOME THERAPEUT                                 | CUSIP: 05464T104<br>LEI: 549300EXGR0XLRJEIB95 | Long             | EC               | CORP              | US        |     98619 | NS      | $10370774.04   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Immunome Inc                                      | IMMUNOME INC                                     | CUSIP: 45257U108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    205648 | NS      | $1801476.48    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Amedisys Inc                                      | AMEDISYS INC                                     | CUSIP: 023436108<br>LEI: 5299001RBS9GK9STN379 | Long             | EC               | CORP              | US        |    102287 | NS      | $9622138.09    | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| AbbVie Inc                                        | ABBVIE INC                                       | CUSIP: 00287Y109<br>LEI: FR5LCKFTG8054YNNRU85 | Long             | EC               | CORP              | US        |   4686678 | NS      | $872237642.58  | 5.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Arbutus Biopharma Corp                            | ARBUTUS BIOPHARM                                 | CUSIP: 03879J100<br>LEI: 25490064CESONAUIAS23 | Long             | EC               | CORP              | US        |    445431 | NS      | $1496648.16    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Pacific Biosciences of California Inc             | PACIFIC BIOSCIEN                                 | CUSIP: 69404D108<br>LEI: 529900F1BWRE1M0KZN89 | Long             | EC               | CORP              | US        |    771977 | NS      | $743954.23     | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| ATAI Life Sciences NV                             | ATAI LIFE SCIENC                                 | CUSIP: N0731H103<br>LEI: 391200Z8UWPJSNBNCA11 | Long             | EC               | CORP              | US        |    387009 | NS      | $893990.79     | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Blueprint Medicines Corp                          | BLUEPRINT MEDICI                                 | CUSIP: 09627Y109<br>LEI: 5299004CC60O9T5HVM83 | Long             | EC               | CORP              | US        |    198702 | NS      | $20138447.70   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Doximity Inc                                      | DOXIMITY INC-A                                   | CUSIP: 26622P107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    341585 | NS      | $17793162.65   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| BioLife Solutions Inc                             | BIOLIFE SOLUTION                                 | CUSIP: 09062W204<br>LEI: 549300G2IVCMC2TJDW72 | Long             | EC               | CORP              | US        |    117096 | NS      | $2562060.48    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Entrada Therapeutics Inc                          | ENTRADA THERAPEU                                 | CUSIP: 29384C108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     52924 | NS      | $402222.40     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Cullinan Therapeutics Inc                         | CULLINAN THERAPE                                 | CUSIP: 230031106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    100159 | NS      | $865874.56     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Harmony Biosciences Holdings Inc                  | HARMONY BIOSCIE                                  | CUSIP: 413197104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    134448 | NS      | $4638456.00    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Stryker Corp                                      | STRYKER CORP                                     | CUSIP: 863667101<br>LEI: 5493002F0SC4JTBU5137 | Long             | EC               | CORP              | US        |   1074949 | NS      | $411318485.36  | 2.36%             |  |  |  | No            |                  1 | On Loan: No      |
| Xencor Inc                                        | XENCOR INC                                       | CUSIP: 98401F105<br>LEI: 549300V5IF65437JKG30 | Long             | EC               | CORP              | US        |    187109 | NS      | $1496872.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Soleno Therapeutics Inc                           | SOLENO THERAPEUT                                 | CUSIP: 834203309<br>LEI: 5493003LCY77N7FXK844 | Long             | EC               | CORP              | US        |     81368 | NS      | $5968342.80    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Orthofix Medical Inc                              | ORTHOFIX MEDICAL                                 | CUSIP: 68752M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    102071 | NS      | $1148298.75    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytek Biosciences Inc                             | CYTEK BIOSCIENCE                                 | CUSIP: 23285D109<br>LEI: 549300K2J28BOC6FBO89 | Long             | EC               | CORP              | US        |    343949 | NS      | $952738.73     | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| MiMedx Group Inc                                  | MIMEDX GROUP INC                                 | CUSIP: 602496101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    369433 | NS      | $2375454.19    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| ResMed Inc                                        | RESMED INC                                       | CUSIP: 761152107<br>LEI: 529900T3QE5253CCXF22 | Long             | EC               | CORP              | US        |    460031 | NS      | $112610988.49  | 0.65%             |  |  |  | No            |                  1 | On Loan: No      |
| Kymera Therapeutics Inc                           | KYMERA THERAPEUT                                 | CUSIP: 501575104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    121950 | NS      | $3614598.00    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Premier Inc                                       | PREMIER INC-CL A                                 | CUSIP: 74051N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    299851 | NS      | $6890575.98    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Sarepta Therapeutics Inc                          | SAREPTA THERAPEU                                 | CUSIP: 803607100<br>LEI: 549300IKDPIED8J8IG21 | Long             | EC               | CORP              | US        |    204609 | NS      | $7693298.40    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Surmodics Inc                                     | SURMODICS INC                                    | CUSIP: 868873100<br>LEI: 549300H76KXCAAGUS878 | Long             | EC               | CORP              | US        |     42664 | NS      | $1238109.28    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Waters Corp                                       | WATERS CORP                                      | CUSIP: 941848103<br>LEI: 5T547R1474YC9HOD8Q74 | Long             | EC               | CORP              | US        |    185942 | NS      | $64938384.08   | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| TG Therapeutics Inc                               | TG THERAPEUTICS                                  | CUSIP: 88322Q108<br>LEI: 529900X21UKABN9NJ529 | Long             | EC               | CORP              | US        |    463712 | NS      | $16280928.32   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Tango Therapeutics Inc                            | TANGO THERAPEUTI                                 | CUSIP: 87583X109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    118615 | NS      | $263325.30     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Ligand Pharmaceuticals Inc                        | LIGAND PHARM                                     | CUSIP: 53220K504<br>LEI: 5493008K7TB0IKP37H79 | Long             | EC               | CORP              | US        |     59338 | NS      | $6063750.22    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Apogee Therapeutics Inc                           | APOGEE THERAPEUT                                 | CUSIP: 03770N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     70818 | NS      | $2594771.52    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Coherus Biosciences Inc                           | COHERUS BIOSCIEN                                 | CUSIP: 19249H103<br>LEI: 5493007IL8W5MV932D26 | Long             | EC               | CORP              | US        |    363981 | NS      | $283541.20     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Applied Therapeutics Inc                          | APPLIED THERAPEU                                 | CUSIP: 03828A101<br>LEI: 549300KL3IJPHZM2GR04 | Long             | EC               | CORP              | US        |    235119 | NS      | $83067.54      | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Twist Bioscience Corp                             | TWIST BIOSCIENCE                                 | CUSIP: 90184D100<br>LEI: 549300T23BL59LCOH584 | Long             | EC               | CORP              | US        |    186160 | NS      | $5454488.00    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| DaVita Inc                                        | DAVITA INC                                       | CUSIP: 23918K108<br>LEI: M2XHYMU3TZNEZURC6H66 | Long             | EC               | CORP              | US        |    141259 | NS      | $19247951.34   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Solventum Corp                                    | SOLVENTUM                                        | CUSIP: 83444M101<br>LEI: 254900I70403OSGY4M28 | Long             | EC               | CORP              | US        |    459719 | NS      | $33600861.71   | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| GeneDx Holdings Corp                              | GENEDX HOLDINGS                                  | CUSIP: 81663L200<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     51801 | NS      | $3689267.22    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Alignment Healthcare Inc                          | ALIGNMENT HEALTH                                 | CUSIP: 01625V104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    300945 | NS      | $4625524.65    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Enanta Pharmaceuticals Inc                        | ENANTA PHARMACEU                                 | CUSIP: 29251M106<br>LEI: 529900SSN4DODDQSN594 | Long             | EC               | CORP              | US        |     63274 | NS      | $375214.82     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| AdaptHealth Corp                                  | ADAPTHEALTH CORP                                 | CUSIP: 00653Q102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    274414 | NS      | $2464237.72    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Dyne Therapeutics Inc                             | DYNE THERAPEUTIC                                 | CUSIP: 26818M108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    191989 | NS      | $2296188.44    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Medpace Holdings Inc                              | MEDPACE HOLDINGS                                 | CUSIP: 58506Q109<br>LEI: 549300H8TYEUVTW14A54 | Long             | EC               | CORP              | US        |     82836 | NS      | $24428336.40   | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Avidity Biosciences Inc                           | AVIDITY BIOSCIEN                                 | CUSIP: 05370A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    260991 | NS      | $8085501.18    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Certara Inc                                       | CERTARA INC                                      | CUSIP: 15687V109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    405224 | NS      | $4603344.64    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| OPKO Health Inc                                   | OPKO HEALTH                                      | CUSIP: 68375N103<br>LEI: 529900A4S2D4OGOJLL02 | Long             | EC               | CORP              | US        |   1069202 | NS      | $1454114.72    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Phreesia Inc                                      | PHREESIA INC                                     | CUSIP: 71944F106<br>LEI: 5493000HHF8NU4QOCG53 | Long             | EC               | CORP              | US        |    172933 | NS      | $4235129.17    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Korro Bio Inc                                     | KORRO BIO INC                                    | CUSIP: 500946108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     14218 | NS      | $162369.56     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Hims & Hers Health Inc                            | HIMS & HERS HEAL                                 | CUSIP: 433000106<br>LEI: 549300ZQ4ZUYSAAX6P59 | Long             | EC               | CORP              | US        |    559989 | NS      | $31672977.84   | 0.18%             |  |  |  | No            |                  1 | On Loan: No      |
| Bristol-Myers Squibb Co                           | BRISTOL-MYER SQB                                 | CUSIP: 110122108<br>LEI: HLYYNH7UQUORYSJQCN42 | Long             | EC               | CORP              | US        |   6354509 | NS      | $306795694.52  | 1.76%             |  |  |  | No            |                  1 | On Loan: No      |
| Cigna Group/The                                   | THE CIGNA GROUP                                  | CUSIP: 125523100<br>LEI: 549300VIWYMSIGT1U456 | Long             | EC               | CORP              | US        |    871443 | NS      | $275933711.52  | 1.58%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvalent Inc                                      | NUVALENT INC-A                                   | CUSIP: 670703107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    112796 | NS      | $8415709.56    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| IQVIA Holdings Inc                                | IQVIA HOLDINGS I                                 | CUSIP: 46266C105<br>LEI: 549300W3R20NM4KQPH86 | Long             | EC               | CORP              | US        |    568457 | NS      | $79771570.81   | 0.46%             |  |  |  | No            |                  1 | On Loan: No      |
| 89bio Inc                                         | 89BIO INC                                        | CUSIP: 282559103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    333331 | NS      | $3279977.04    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| WaVe Life Sciences Ltd                            | WAVE LIFE SCIENC                                 | CUSIP: Y95308105<br>LEI: 54930070006GPKFYZ813 | Long             | EC               | CORP              | US        |    311610 | NS      | $1872776.10    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Roivant Sciences Ltd                              | ROIVANT SCIENCES                                 | CUSIP: G76279101<br>LEI: 549300DL466NY5J6U724 | Long             | EC               | CORP              | US        |   1138973 | NS      | $12517313.27   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Rocket Pharmaceuticals Inc                        | ROCKET PHARMACEU                                 | CUSIP: 77313F106<br>LEI: 549300R7VV82YUIN4Y93 | Long             | EC               | CORP              | US        |    251691 | NS      | $631744.41     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Mural Oncology PLC                                | MURAL ONCOLOGY                                   | CUSIP: G63365103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     47280 | NS      | $123873.60     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Arrowhead Pharmaceuticals Inc                     | ARROWHEAD PHARMA                                 | CUSIP: 04280A100<br>LEI: 549300O3CSB8T7OZ3D66 | Long             | EC               | CORP              | US        |    351540 | NS      | $5649247.80    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Dianthus Therapeutics Inc                         | DIANTHUS THERAPE                                 | CUSIP: 252828108<br>LEI: 549300Z3N6ODPCOFC890 | Long             | EC               | CORP              | US        |     23134 | NS      | $402300.26     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Adaptive Biotechnologies Corp                     | ADAPTIVE BIOTECH                                 | CUSIP: 00650F109<br>LEI: 549300ZTF7OT1FW66Q96 | Long             | EC               | CORP              | US        |    324742 | NS      | $3091543.84    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| FibroGen Inc                                      | FIBROGEN INC                                     | CUSIP: 31572Q808<br>LEI: 549300Q914ULWWY95822 | Long             | EC               | CORP              | US        |    305888 | NS      | $87973.39      | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Regeneron Pharmaceuticals Inc                     | REGENERON PHARM                                  | CUSIP: 75886F107<br>LEI: 549300RCBFWIRX3HYQ56 | Long             | EC               | CORP              | US        |    338648 | NS      | $166032341.44  | 0.95%             |  |  |  | No            |                  1 | On Loan: No      |
| Bioventus Inc                                     | BIOVENTUS - A                                    | CUSIP: 09075A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    112882 | NS      | $731475.36     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Sana Biotechnology Inc                            | SANA BIOTECHNOLO                                 | CUSIP: 799566104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    386100 | NS      | $837837.00     | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| Arvinas Inc                                       | ARVINAS INC                                      | CUSIP: 04335A105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    151518 | NS      | $1090929.60    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| STAAR Surgical Co                                 | STAAR SURGICAL                                   | CUSIP: 852312305<br>LEI: 5299006LRHI7OJ8BY308 | Long             | EC               | CORP              | US        |    123908 | NS      | $2206801.48    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Recursion Pharmaceuticals Inc                     | RECURSION PHAR-A                                 | CUSIP: 75629V104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    785080 | NS      | $3281634.40    | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| agilon health Inc                                 | AGILON HEALTH IN                                 | CUSIP: 00857U107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    972054 | NS      | $2157959.88    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| DENTSPLY SIRONA Inc                               | DENTSPLY SIRONA                                  | CUSIP: 24906P109<br>LEI: 9NHEHR1SOZCYXDO8HO28 | Long             | EC               | CORP              | US        |    621473 | NS      | $9931138.54    | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Bridgebio Pharma Inc                              | BRIDGEBIO PHARMA                                 | CUSIP: 10806X102<br>LEI: 54930028YG89VTY2J114 | Long             | EC               | CORP              | US        |    384738 | NS      | $13177276.50   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Enovis Corp                                       | ENOVIS CORP                                      | CUSIP: 194014502<br>LEI: 635400OP2DYYYMOIYL17 | Long             | EC               | CORP              | US        |    175578 | NS      | $5495591.40    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Ocugen Inc                                        | OCUGEN INC                                       | CUSIP: 67577C105<br>LEI: 549300JVNUI9CXWJLR09 | Long             | EC               | CORP              | US        |    904904 | NS      | $756590.23     | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| Nurix Therapeutics Inc                            | NURIX THERAPEUTI                                 | CUSIP: 67080M103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    189278 | NS      | $2012025.14    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| HCA Healthcare Inc                                | HCA HEALTHCARE I                                 | CUSIP: 40412C101<br>LEI: 529900PH4ZGUH2MNEU89 | Long             | EC               | CORP              | US        |    595178 | NS      | $226994937.42  | 1.30%             |  |  |  | No            |                  1 | On Loan: No      |
| Bruker Corp                                       | BRUKER CORP                                      | CUSIP: 116794108<br>LEI: LEBZ6VLQ6I8XB1NHVY15 | Long             | EC               | CORP              | US        |    331463 | NS      | $12164692.10   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| AngioDynamics Inc                                 | ANGIODYNAMICS IN                                 | CUSIP: 03475V101<br>LEI: 549300W3VKC5ZKMO8C28 | Long             | EC               | CORP              | US        |    126693 | NS      | $1292268.60    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| PROCEPT BioRobotics Corp                          | PROCEPT BIOROBOT                                 | CUSIP: 74276L105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    160724 | NS      | $9321992.00    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| BioMarin Pharmaceutical Inc                       | BIOMARIN PHARMAC                                 | CUSIP: 09061G101<br>LEI: NSLL8ITTRR0J5HEMR848 | Long             | EC               | CORP              | US        |    596656 | NS      | $34647813.92   | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Amylyx Pharmaceuticals Inc                        | AMYLYX PHARMACEU                                 | CUSIP: 03237H101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    187646 | NS      | $966376.90     | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Edgewise Therapeutics Inc                         | EDGEWISE THERAPE                                 | CUSIP: 28036F105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    147619 | NS      | $2107999.32    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Vanguard Cmt Funds-Vanguard Market Liquidity Fund | Vanguard Market Liquidity Fund                   | CUSIP: N/A<br>LEI: 1I6HV0TLSTR3A4XQ6L78       | Long             | STIV             | CORP              | US        |    436086 | NS      | $43604203.64   | 0.25%             |  |  |  | No            |                  1 | On Loan: No      |
| Illumina Inc                                      | ILLUMINA INC                                     | CUSIP: 452327109<br>LEI: SQ95QG8SR5Q56LSNF682 | Long             | EC               | CORP              | US        |    496397 | NS      | $40823689.28   | 0.23%             |  |  |  | No            |                  1 | On Loan: No      |
| Aldeyra Therapeutics Inc                          | ALDEYRA THERAPEU                                 | CUSIP: 01438T106<br>LEI: 529900HGKY864E4Y9014 | Long             | EC               | CORP              | US        |    139306 | NS      | $299507.90     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Biogen Inc                                        | BIOGEN INC                                       | CUSIP: 09062X103<br>LEI: W8J5WZB5IY3K0NDQT671 | Long             | EC               | CORP              | US        |    456380 | NS      | $59233560.20   | 0.34%             |  |  |  | No            |                  1 | On Loan: No      |
| Merck & Co Inc                                    | MERCK & CO                                       | CUSIP: 58933Y105<br>LEI: 4YV9Y5M8S0BRK1RP0397 | Long             | EC               | CORP              | US        |   7925657 | NS      | $609007483.88  | 3.49%             |  |  |  | No            |                  1 | On Loan: No      |
| Ventyx Biosciences Inc                            | VENTYX BIOSCIENC                                 | CUSIP: 92332V107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    156581 | NS      | $266187.70     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Ardelyx Inc                                       | ARDELYX INC                                      | CUSIP: 039697107<br>LEI: 549300F542QR4SXHCY32 | Long             | EC               | CORP              | US        |    740429 | NS      | $2717374.43    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Organon & Co                                      | ORGANON & CO                                     | CUSIP: 68622V106<br>LEI: 549300AMCKY57OK2CO56 | Long             | EC               | CORP              | US        |    806128 | NS      | $7432500.16    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| National HealthCare Corp                          | NATL HEALTHCARE                                  | CUSIP: 635906100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     41304 | NS      | $4301398.56    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| HealthEquity Inc                                  | HEALTHEQUITY INC                                 | CUSIP: 42226A107<br>LEI: 529900LRJU1RAFQHM467 | Long             | EC               | CORP              | US        |    271092 | NS      | $27274566.12   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Azenta Inc                                        | AZENTA INC                                       | CUSIP: 114340102<br>LEI: 35ZN6X1ANPH25YN32Y17 | Long             | EC               | CORP              | US        |    129298 | NS      | $3454842.56    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Theravance Biopharma Inc                          | THERAVANCE B                                     | CUSIP: G8807B106<br>LEI: 5493007VTSXP4Z6MIW52 | Long             | EC               | CORP              | US        |    113157 | NS      | $1036518.12    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Praxis Precision Medicines Inc                    | PRAXIS PRECISION                                 | CUSIP: 74006W207<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     43954 | NS      | $1694426.70    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Harrow Inc                                        | HARROW INC                                       | CUSIP: 415858109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     94966 | NS      | $2669494.26    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| ModivCare Inc                                     | MODIVCARE INC                                    | CUSIP: 60783X104<br>LEI: 549300EFZIFW7F7I0Q28 | Long             | EC               | CORP              | US        |     22685 | NS      | $25407.20      | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| Akero Therapeutics Inc                            | AKERO THERAPEUTI                                 | CUSIP: 00973Y108<br>LEI: 549300SI3KG74LBE2955 | Long             | EC               | CORP              | US        |    153093 | NS      | $7601067.45    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Emergent BioSolutions Inc                         | EMERGENT BIOSOLU                                 | CUSIP: 29089Q105<br>LEI: 549300YW6TUOX8BE5103 | Long             | EC               | CORP              | US        |    170078 | NS      | $1074892.96    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Standard BioTools Inc                             | STANDARD BIOTOOL                                 | CUSIP: 34385P108<br>LEI: 549300GX8Y96GSB6YP89 | Long             | EC               | CORP              | US        |    699854 | NS      | $706852.54     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Baxter International Inc                          | BAXTER INTL INC                                  | CUSIP: 071813109<br>LEI: J5OIVXX3P24RJRW5CK77 | Long             | EC               | CORP              | US        |   1599178 | NS      | $48774929.00   | 0.28%             |  |  |  | No            |                  1 | On Loan: No      |
| Summit Therapeutics Inc                           | SUMMIT THERAPEUT                                 | CUSIP: 86627T108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    462010 | NS      | $8415512.15    | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| RadNet Inc                                        | RADNET INC                                       | CUSIP: 750491102<br>LEI: 529900RECG94V2IZJ970 | Long             | EC               | CORP              | US        |    196843 | NS      | $11316504.07   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| GoodRx Holdings Inc                               | GOODRX HOLDIN-A                                  | CUSIP: 38246G108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    279088 | NS      | $1094024.96    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Sotera Health Co                                  | SOTERA HEALTH CO                                 | CUSIP: 83601L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    486253 | NS      | $5951736.72    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Agenus Inc                                        | AGENUS INC                                       | CUSIP: 00847G804<br>LEI: 529900NDQQGU5H4UJK81 | Long             | EC               | CORP              | US        |     74061 | NS      | $254029.23     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| US Physical Therapy Inc                           | US PHYSICAL THER                                 | CUSIP: 90337L108<br>LEI: 529900KL1UXQYFIOMY96 | Long             | EC               | CORP              | US        |     47407 | NS      | $3555050.93    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| MeiraGTx Holdings plc                             | MEIRAGTX HOLDING                                 | CUSIP: G59665102<br>LEI: 54930007YV6NYIOGFZ57 | Long             | EC               | CORP              | US        |    147525 | NS      | $755328.00     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| SIGA Technologies Inc                             | SIGA TECH INC                                    | CUSIP: 826917106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    135419 | NS      | $809805.62     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Encompass Health Corp                             | ENCOMPASS HEALTH                                 | CUSIP: 29261A100<br>LEI: 549300FVRPM9DRQZRG64 | Long             | EC               | CORP              | US        |    315887 | NS      | $38190738.30   | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| OraSure Technologies Inc                          | ORASURE TECH                                     | CUSIP: 68554V108<br>LEI: 529900GNNJPNM4XHXQ77 | Long             | EC               | CORP              | US        |    232496 | NS      | $669588.48     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Protagonist Therapeutics Inc                      | PROTAGONIST THER                                 | CUSIP: 74366E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    140524 | NS      | $6670674.28    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                               | Receive AVANTOR INC Pay Overnight Rate           | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | N/A       |    162000 | NC      | $-12960.00     | -0.00%            |  |  |  | No            |                  2 | On Loan: No      |
| Seres Therapeutics Inc                            | SERES THERAPEUTI                                 | CUSIP: 81750R201<br>LEI: 549300GMXBE5NUWISF13 | Long             | EC               | CORP              | US        |     19151 | NS      | $135014.55     | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| IGM Biosciences Inc                               | IGM BIOSCIENCES                                  | CUSIP: 449585108<br>LEI: 5493008XCQES2N0VY969 | Long             | EC               | CORP              | US        |     36758 | NS      | $46682.66      | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Astria Therapeutics Inc                           | ASTRIA THERAPEUT                                 | CUSIP: 04635X102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     80355 | NS      | $382489.80     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Charles River Laboratories International Inc      | CHARLES RIVER LA                                 | CUSIP: 159864107<br>LEI: 549300BSQ0R4UZ5KX287 | Long             | EC               | CORP              | US        |    160344 | NS      | $21747456.72   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| Zimvie Inc                                        | ZIMVIE INC                                       | CUSIP: 98888T107<br>LEI: 549300GFKURT1J6XR665 | Long             | EC               | CORP              | US        |     87671 | NS      | $801312.94     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| NeoGenomics Inc                                   | NEOGENOMICS INC                                  | CUSIP: 64049M209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    401501 | NS      | $2922927.28    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Inspire Medical Systems Inc                       | INSPIRE MEDICAL                                  | CUSIP: 457730109<br>LEI: 549300XQQCQ7HCJKTW25 | Long             | EC               | CORP              | US        |     93874 | NS      | $12973386.80   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Butterfly Network Inc                             | BUTTERFLY NETWOR                                 | CUSIP: 124155102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    439144 | NS      | $1053945.60    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Zentalis Pharmaceuticals Inc                      | ZENTALIS PHARMAC                                 | CUSIP: 98943L107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    155001 | NS      | $187551.21     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Perspective Therapeutics Inc                      | PERSPECTIVE THER                                 | CUSIP: 46489V302<br>LEI: 5493005LRKM6BCABC605 | Long             | EC               | CORP              | US        |    137865 | NS      | $354313.05     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Mirum Pharmaceuticals Inc                         | MIRUM PHARMACEUT                                 | CUSIP: 604749101<br>LEI: 254900YZKR40F7F27K81 | Long             | EC               | CORP              | US        |    113198 | NS      | $5032783.08    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Teleflex Inc                                      | TELEFLEX INC                                     | CUSIP: 879369106<br>LEI: UUL85LWXB4NGSWWXIQ25 | Long             | EC               | CORP              | US        |    145664 | NS      | $17810337.28   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Immunovant Inc                                    | IMMUNOVANT INC                                   | CUSIP: 45258J102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    212422 | NS      | $3154466.70    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Ultragenyx Pharmaceutical Inc                     | ULTRAGENYX PHARM                                 | CUSIP: 90400D108<br>LEI: 529900EV44GVDN1DCX77 | Long             | EC               | CORP              | US        |    260853 | NS      | $8876827.59    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Day One Biopharmaceuticals Inc                    | DAY ONE BIOPHARM                                 | CUSIP: 23954D109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    174435 | NS      | $1112895.30    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Relay Therapeutics Inc                            | RELAY THERAPEUTI                                 | CUSIP: 75943R102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    369936 | NS      | $1109808.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Cabaletta Bio Inc                                 | CABALETTA BIO IN                                 | CUSIP: 12674W109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    122321 | NS      | $228740.27     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Maravai LifeSciences Holdings Inc                 | MARAVAI LIFESC-A                                 | CUSIP: 56600D107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    357290 | NS      | $803902.50     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Community Health Systems Inc                      | COMMUNITY HEALTH                                 | CUSIP: 203668108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    394465 | NS      | $1530524.20    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Allogene Therapeutics Inc                         | ALLOGENE THERAPE                                 | CUSIP: 019770106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    459663 | NS      | $537805.71     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| 10X Genomics Inc                                  | 10X GENOMICS I-A                                 | CUSIP: 88025U109<br>LEI: 5493003Z6741WNLG7H43 | Long             | EC               | CORP              | US        |    301340 | NS      | $2871770.20    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Erasca Inc                                        | ERASCA INC                                       | CUSIP: 29479A108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    534281 | NS      | $747993.40     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcutis Biotherapeutics Inc                       | ARCUTIS BIOTHERA                                 | CUSIP: 03969K108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    329549 | NS      | $4297318.96    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Pfizer Inc                                        | PFIZER INC                                       | CUSIP: 717081103<br>LEI: 765LHXWGK1KXCLTFYQ30 | Long             | EC               | CORP              | US        |  17754739 | NS      | $417058819.11  | 2.39%             |  |  |  | No            |                  1 | On Loan: No      |
| Enhabit Inc                                       | ENHABIT INC                                      | CUSIP: 29332G102<br>LEI: 549300RFQ78SLDFSHF49 | Long             | EC               | CORP              | US        |    135294 | NS      | $1420587.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| LivaNova PLC                                      | LIVANOVA PLC                                     | CUSIP: G5509L101<br>LEI: 2138001K2FX6SHK2B339 | Long             | EC               | CORP              | US        |    169787 | NS      | $7343287.75    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Artivion Inc                                      | ARTIVION INC                                     | CUSIP: 228903100<br>LEI: 549300YTKV8DMSMG6K81 | Long             | EC               | CORP              | US        |    117308 | NS      | $3469970.64    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| ACADIA Pharmaceuticals Inc                        | ACADIA PHARMACEU                                 | CUSIP: 004225108<br>LEI: 529900O3044NO0PEA039 | Long             | EC               | CORP              | US        |    339067 | NS      | $7313675.19    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| ANI Pharmaceuticals Inc                           | ANI PHARMACEUTIC                                 | CUSIP: 00182C103<br>LEI: 5493000T6CXTND40YH31 | Long             | EC               | CORP              | US        |     52515 | NS      | $3083680.80    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Ensign Group Inc/The                              | ENSIGN GROUP INC                                 | CUSIP: 29358P101<br>LEI: 5493003K4HEEA8Q0BC72 | Long             | EC               | CORP              | US        |    179620 | NS      | $26450841.20   | 0.15%             |  |  |  | No            |                  1 | On Loan: No      |
| Mesa Laboratories Inc                             | MESA LABS                                        | CUSIP: 59064R109<br>LEI: 549300ZCG738WLX8ZW79 | Long             | EC               | CORP              | US        |     17076 | NS      | $1718187.12    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Editas Medicine Inc                               | EDITAS MEDICINE                                  | CUSIP: 28106W103<br>LEI: 5299000AON4Q9NT2JE42 | Long             | EC               | CORP              | US        |    247981 | NS      | $426527.32     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Elevance Health Inc                               | ELEVANCE HEALTH                                  | CUSIP: 036752103<br>LEI: 8MYN82XMYQH89CTMTH67 | Long             | EC               | CORP              | US        |    726624 | NS      | $278907356.16  | 1.60%             |  |  |  | No            |                  1 | On Loan: No      |
| Revvity Inc                                       | REVVITY INC                                      | CUSIP: 714046109<br>LEI: 549300IKL1SDPFI7N655 | Long             | EC               | CORP              | US        |    381531 | NS      | $34498033.02   | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Vanda Pharmaceuticals Inc                         | VANDA PHARMACEUT                                 | CUSIP: 921659108<br>LEI: 529900AY8VOOQBKJ0O70 | Long             | EC               | CORP              | US        |    184429 | NS      | $800421.86     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| 4D Molecular Therapeutics Inc                     | 4D MOLECULAR THE                                 | CUSIP: 35104E100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     81961 | NS      | $296698.82     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| LifeStance Health Group Inc                       | LIFESTANCE HEALT                                 | CUSIP: 53228F101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    421859 | NS      | $2505842.46    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| OmniAb Inc                                        | OMNIAB INC - 12.5                                | CUSIP: 68218J202<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     22076 | NS      | $0.22          | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| AnaptysBio Inc                                    | ANAPTYSBIO INC                                   | CUSIP: 032724106<br>LEI: 529900HH4WQT03IG1A12 | Long             | EC               | CORP              | US        |     52661 | NS      | $1170654.03    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                               | Receive JOHNSON&JOHNSON Pay Overnight Rate +0.75 | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | N/A       |    850000 | NC      | $-934991.50    | -0.01%            |  |  |  | No            |                  2 | On Loan: No      |
| N/A                                               | Receive SAREPTA THERAPEU Pay Overnight Rate      | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | N/A       |     65000 | NC      | $-1612000.00   | -0.01%            |  |  |  | No            |                  2 | On Loan: No      |
| Scholar Rock Holding Corp                         | SCHOLAR ROCK HOL                                 | CUSIP: 80706P103<br>LEI: 549300Z1FLPGL4OWJ459 | Long             | EC               | CORP              | US        |    206024 | NS      | $5976756.24    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Tarsus Pharmaceuticals Inc                        | TARSUS PHARMACEU                                 | CUSIP: 87650L103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     90189 | NS      | $3873617.55    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Evolent Health Inc                                | EVOLENT HEALTH-A                                 | CUSIP: 30050B101<br>LEI: 549300CZOCFHQ2BBTR11 | Long             | EC               | CORP              | US        |    311219 | NS      | $2318581.55    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                               | Receive ABBVIE INC Pay Overnight Rate +0.7       | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | N/A       |    550000 | NC      | $-4944500.00   | -0.03%            |  |  |  | No            |                  2 | On Loan: No      |
| Lantheus Holdings Inc                             | LANTHEUS HOLDING                                 | CUSIP: 516544103<br>LEI: 5299005HUB5IOJGO7S39 | Long             | EC               | CORP              | US        |    217998 | NS      | $16471928.88   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Amphastar Pharmaceuticals Inc                     | AMPHASTAR PHARMA                                 | CUSIP: 03209R103<br>LEI: 54930055TH0ZLSAQMJ38 | Long             | EC               | CORP              | US        |    120962 | NS      | $3109933.02    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Catalyst Pharmaceuticals Inc                      | CATALYST PHARMAC                                 | CUSIP: 14888U101<br>LEI: 5299004O0R5XXLA5H544 | Long             | EC               | CORP              | US        |    335981 | NS      | $8386085.76    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Globus Medical Inc                                | GLOBUS MEDICAL I                                 | CUSIP: 379577208<br>LEI: 5299003M2P4CIK0RF205 | Long             | EC               | CORP              | US        |    256755 | NS      | $15194760.90   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Fate Therapeutics Inc                             | FATE THERAPEUTIC                                 | CUSIP: 31189P102<br>LEI: 549300L14Q4UHOODLA90 | Long             | EC               | CORP              | US        |    229582 | NS      | $277794.22     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Teladoc Health Inc                                | TELADOC HEALTH I                                 | CUSIP: 87918A105<br>LEI: 549300I2PVFBC9MFAC61 | Long             | EC               | CORP              | US        |    539282 | NS      | $3731831.44    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Replimune Group Inc                               | REPLIMUNE GROUP                                  | CUSIP: 76029N106<br>LEI: 549300AY704NEIRC4K64 | Long             | EC               | CORP              | US        |    169338 | NS      | $1520655.24    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Veracyte Inc                                      | VERACYTE INC                                     | CUSIP: 92337F107<br>LEI: 529900ESWZRHXOW27Z37 | Long             | EC               | CORP              | US        |    243257 | NS      | $6473068.77    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Stoke Therapeutics Inc                            | STOKE THERAPEUTI                                 | CUSIP: 86150R107<br>LEI: 549300RD25SS2DIJHJ67 | Long             | EC               | CORP              | US        |    107636 | NS      | $1026847.44    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Henry Schein Inc                                  | HENRY SCHEIN INC                                 | CUSIP: 806407102<br>LEI: VGO3WGL8H45T73F4RR92 | Long             | EC               | CORP              | US        |    390946 | NS      | $27362310.54   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Avanos Medical Inc                                | AVANOS MEDICAL I                                 | CUSIP: 05350V106<br>LEI: 549300YCXWOM7NEWMQ58 | Long             | EC               | CORP              | US        |    145102 | NS      | $1823932.14    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Cargo Therapeutics Inc                            | CARGO THERAPEUTI                                 | CUSIP: 14179K101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     57677 | NS      | $245127.25     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Crinetics Pharmaceuticals Inc                     | CRINETICS PHARMA                                 | CUSIP: 22663K107<br>LEI: 549300Q1CNFXK5P31D28 | Long             | EC               | CORP              | US        |    260974 | NS      | $7962316.74    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Pliant Therapeutics Inc                           | PLIANT THERAPEUT                                 | CUSIP: 729139105<br>LEI: 5493002Q5LITR7VHZH02 | Long             | EC               | CORP              | US        |    153000 | NS      | $206550.00     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Incyte Corp                                       | INCYTE CORP                                      | CUSIP: 45337C102<br>LEI: 549300Z4WN6JVZ3T4680 | Long             | EC               | CORP              | US        |    512666 | NS      | $33354049.96   | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Biomea Fusion Inc                                 | BIOMEA FUSION IN                                 | CUSIP: 09077A106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     79604 | NS      | $114629.76     | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| CryoPort Inc                                      | CRYOPORT                                         | CUSIP: 229050307<br>LEI: 9845004D8538BT8JF626 | Long             | EC               | CORP              | US        |    155707 | NS      | $935799.07     | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Ionis Pharmaceuticals Inc                         | IONIS PHARMACEUT                                 | CUSIP: 462222100<br>LEI: 549300SI4ZGLG0BLUZ92 | Long             | EC               | CORP              | US        |    444771 | NS      | $14904276.21   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Biohaven Ltd                                      | BIOHAVEN LTD                                     | CUSIP: G1110E107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    268559 | NS      | $3977358.79    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Krystal Biotech Inc                               | KRYSTAL BIOTECH                                  | CUSIP: 501147102<br>LEI: 549300YONUY68210OE41 | Long             | EC               | CORP              | US        |     67520 | NS      | $8504819.20    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Organogenesis Holdings Inc                        | ORGANOGENESIS HO                                 | CUSIP: 68621F102<br>LEI: 549300RLC2O821TU6941 | Long             | EC               | CORP              | US        |    173105 | NS      | $474307.70     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Nuvation Bio Inc                                  | NUVATION BIO INC                                 | CUSIP: 67080N101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    682502 | NS      | $1446904.24    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Neurocrine Biosciences Inc                        | NEUROCRINE BIOSC                                 | CUSIP: 64125C109<br>LEI: 549300FECER0XBN49756 | Long             | EC               | CORP              | US        |    317038 | NS      | $39002014.76   | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Jazz Pharmaceuticals PLC                          | JAZZ PHARMACEUTI                                 | CUSIP: G50871105<br>LEI: 635400GAUMJCLEZRRV50 | Long             | EC               | CORP              | US        |    180072 | NS      | $19460381.04   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| ARS Pharmaceuticals Inc                           | ARS PHARMACEUTIC                                 | CUSIP: 82835W108<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    122914 | NS      | $1773649.02    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Vanguard Cmt Funds-Vanguard Market Liquidity Fund | Vanguard Market Liquidity Fund                   | CUSIP: N/A<br>LEI: 1I6HV0TLSTR3A4XQ6L78       | Long             | STIV             | CORP              | US        | 484700998 | NS      | $484652527.90  | 2.78%             |  |  |  | No            |                  1 | On Loan: No      |
| Boston Scientific Corp                            | BOSTON SCIENTIFC                                 | CUSIP: 101137107<br>LEI: Y6ZDD9FP4P8JSSJMW954 | Long             | EC               | CORP              | US        |   4617410 | NS      | $486028576.60  | 2.79%             |  |  |  | No            |                  1 | On Loan: No      |
| Eli Lilly & Co                                    | ELI LILLY & CO                                   | CUSIP: 532457108<br>LEI: FRDRIPF3EKNDJ2CQJL29 | Long             | EC               | CORP              | US        |   2528100 | NS      | $1864903527.00 | 10.69%            |  |  |  | No            |                  1 | On Loan: No      |
| Elanco Animal Health Inc                          | ELANCO ANIMAL HE                                 | CUSIP: 28414H103<br>LEI: 549300SHPNDCE059M934 | Long             | EC               | CORP              | US        |   1547664 | NS      | $20800604.16   | 0.12%             |  |  |  | No            |                  1 | On Loan: No      |
| CRISPR Therapeutics AG                            | CRISPR THERAPEUT                                 | CUSIP: H17182108<br>LEI: 506700O6IRRIQLT3W370 | Long             | EC               | CORP              | US        |    254563 | NS      | $9238091.27    | 0.05%             |  |  |  | No            |                  1 | On Loan: —       |
| Avadel Pharmaceuticals PLC                        | AVADEL PHARMACEU                                 | CUSIP: G29687103<br>LEI: 549300E27PTSG2RHC762 | Long             | EC               | CORP              | US        |    272468 | NS      | $2482183.48    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| MaxCyte Inc                                       | MAXCYTE INC                                      | CUSIP: 57777K106<br>LEI: 54930053YHXULRFCU991 | Long             | EC               | CORP              | US        |    313684 | NS      | $746567.92     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Heron Therapeutics Inc                            | HERON THERAPEUTI                                 | CUSIP: 427746102<br>LEI: 549300DR2I1DOPD2IX53 | Long             | EC               | CORP              | US        |    382989 | NS      | $720019.32     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Enliven Therapeutics Inc                          | ENLIVEN THERAPEU                                 | CUSIP: 29337E102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     69309 | NS      | $1231620.93    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Abbott Laboratories                               | ABBOTT LABS                                      | CUSIP: 002824100<br>LEI: HQD377W2YR662HK5JX27 | Long             | EC               | CORP              | US        |   5434649 | NS      | $725960413.42  | 4.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Owens & Minor Inc                                 | OWENS & MINOR                                    | CUSIP: 690732102<br>LEI: 549300LMT5KQQXCEZ733 | Long             | EC               | CORP              | US        |    230435 | NS      | $1520871.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| QuidelOrtho Corp                                  | QUIDELORTHO CORP                                 | CUSIP: 219798105<br>LEI: 549300YU8CMO9HF53113 | Long             | EC               | CORP              | US        |    210143 | NS      | $6445085.81    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Myriad Genetics Inc                               | MYRIAD GENETICS                                  | CUSIP: 62855J104<br>LEI: 52990044IHUOUMETT163 | Long             | EC               | CORP              | US        |    285680 | NS      | $1196999.20    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Addus HomeCare Corp                               | ADDUS HOMECARE                                   | CUSIP: 006739106<br>LEI: 52990090ZT33AKPDBX62 | Long             | EC               | CORP              | US        |     56952 | NS      | $6316546.32    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| HilleVax Inc                                      | HILLEVAX INC                                     | CUSIP: 43157M102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     58358 | NS      | $109129.46     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Spyre Therapeutics Inc                            | SPYRE THERAPEUTI                                 | CUSIP: 00773J202<br>LEI: 52990017AIJPRH3HQH40 | Long             | EC               | CORP              | US        |    109987 | NS      | $1680601.36    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Verve Therapeutics Inc                            | VERVE THERAPEUTI                                 | CUSIP: 92539P101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    199801 | NS      | $889114.45     | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| CareDx Inc                                        | CAREDX INC                                       | CUSIP: 14167L103<br>LEI: 549300NQOFKL9NON0U06 | Long             | EC               | CORP              | US        |    160114 | NS      | $2720336.86    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Rhythm Pharmaceuticals Inc                        | RHYTHM PHARMACEU                                 | CUSIP: 76243J105<br>LEI: 529900JPNWXQ8DPLA551 | Long             | EC               | CORP              | US        |    144081 | NS      | $8836487.73    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcus Biosciences Inc                             | ARCUS BIOSCIENCE                                 | CUSIP: 03969F109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    214864 | NS      | $1918735.52    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Evolus Inc                                        | EVOLUS INC                                       | CUSIP: 30052C107<br>LEI: 549300VYQRYBQOT8V419 | Long             | EC               | CORP              | US        |    148881 | NS      | $1368216.39    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Madrigal Pharmaceuticals Inc                      | MADRIGAL PHARMAC                                 | CUSIP: 558868105<br>LEI: 549300CHIMT2EUSNJB60 | Long             | EC               | CORP              | US        |     40992 | NS      | $11283457.92   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| CorVel Corp                                       | CORVEL CORP                                      | CUSIP: 221006109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     88409 | NS      | $9837269.43    | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| uniQure NV                                        | UNIQURE NV                                       | CUSIP: N90064101<br>LEI: 724500RPCTZLFYJZ3S98 | Long             | EC               | CORP              | US        |    137890 | NS      | $1995268.30    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| OmniAb Inc                                        | OMNIAB INC                                       | CUSIP: 68218J103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    273483 | NS      | $347323.41     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Pulse Biosciences Inc                             | PULSE BIOSCIENCE                                 | CUSIP: 74587B101<br>LEI: 529900NJUBI06118FM73 | Long             | EC               | CORP              | US        |     38720 | NS      | $670049.60     | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| Collegium Pharmaceutical Inc                      | COLLEGIUM PHARMA                                 | CUSIP: 19459J104<br>LEI: 54930049FXZMTLW8D496 | Long             | EC               | CORP              | US        |    101335 | NS      | $2952901.90    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Tandem Diabetes Care Inc                          | TANDEM DIABETES                                  | CUSIP: 875372203<br>LEI: 549300JEPFOD0K4D3I05 | Long             | EC               | CORP              | US        |    205908 | NS      | $4081096.56    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Tyra Biosciences Inc                              | TYRA BIOSCIENCES                                 | CUSIP: 90240B106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     47760 | NS      | $434616.00     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Intuitive Surgical Inc                            | INTUITIVE SURGIC                                 | CUSIP: 46120E602<br>LEI: 54930052SRG011710797 | Long             | EC               | CORP              | US        |   1115835 | NS      | $616320303.90  | 3.53%             |  |  |  | No            |                  1 | On Loan: No      |
| Dexcom Inc                                        | DEXCOM                                           | CUSIP: 252131107<br>LEI: 549300YSK3QDSFR5EU59 | Long             | EC               | CORP              | US        |   1223963 | NS      | $105016025.40  | 0.60%             |  |  |  | No            |                  1 | On Loan: No      |
| iRadimed Corp                                     | IRADIMED CORP                                    | CUSIP: 46266A109<br>LEI: 549300YVHWP0YJ1YW816 | Long             | EC               | CORP              | US        |     23931 | NS      | $1385126.28    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Cytokinetics Inc                                  | CYTOKINETICS INC                                 | CUSIP: 23282W605<br>LEI: 549300BE5DY1HW7IHA64 | Long             | EC               | CORP              | US        |    351073 | NS      | $10890284.46   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| Zoetis Inc                                        | ZOETIS INC                                       | CUSIP: 98978V103<br>LEI: 549300HD9Q1LOC9KLJ48 | Long             | EC               | CORP              | US        |   1413440 | NS      | $238348387.20  | 1.37%             |  |  |  | No            |                  1 | On Loan: No      |
| PACS Group Inc                                    | PACS GROUP INC                                   | CUSIP: 69380Q107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    146645 | NS      | $1454718.40    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Iovance Biotherapeutics Inc                       | IOVANCE BIOTHERA                                 | CUSIP: 462260100<br>LEI: 2549002L8WT2ACU5Q878 | Long             | EC               | CORP              | US        |    668673 | NS      | $1170177.75    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Pulmonx Corp                                      | PULMONX CORP                                     | CUSIP: 745848101<br>LEI: 549300WZMFR0ZK7RJY40 | Long             | EC               | CORP              | US        |    114089 | NS      | $387902.60     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Prestige Consumer Healthcare Inc                  | PRESTIGE CONSUME                                 | CUSIP: 74112D101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    154980 | NS      | $13277136.60   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Alector Inc                                       | ALECTOR INC                                      | CUSIP: 014442107<br>LEI: 549300Z8RQOIY1JMHC25 | Long             | EC               | CORP              | US        |    210854 | NS      | $280435.82     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Repare Therapeutics Inc                           | REPARE THERAPEUT                                 | CUSIP: 760273102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     52521 | NS      | $71953.77      | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Tenet Healthcare Corp                             | TENET HEALTHCARE                                 | CUSIP: 88033G407<br>LEI: 0W9AIBT6U6ADJ2I8HK17 | Long             | EC               | CORP              | US        |    297742 | NS      | $50249917.34   | 0.29%             |  |  |  | No            |                  1 | On Loan: No      |
| Agilent Technologies Inc                          | AGILENT TECH INC                                 | CUSIP: 00846U101<br>LEI: QUIX8Y7A2WP0XRMW7G29 | Long             | EC               | CORP              | US        |    894521 | NS      | $100114790.32  | 0.57%             |  |  |  | No            |                  1 | On Loan: No      |
| Pennant Group Inc/The                             | PENNANT GROUP-WI                                 | CUSIP: 70805E109<br>LEI: 5493007H2OYR6BYLDA64 | Long             | EC               | CORP              | US        |    108001 | NS      | $3100708.71    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| TransMedics Group Inc                             | TRANSMEDICS GROU                                 | CUSIP: 89377M109<br>LEI: 549300060GVOSMWARH50 | Long             | EC               | CORP              | US        |    104922 | NS      | $13337684.64   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| EyePoint Pharmaceuticals Inc                      | EYEPOINT PHARMAC                                 | CUSIP: 30233G209<br>LEI: 549300QE1RU34T50MR69 | Long             | EC               | CORP              | US        |    183122 | NS      | $1325803.28    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcellx Inc                                       | ARCELLX INC                                      | CUSIP: 03940C100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    101327 | NS      | $6288353.62    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| ORIC Pharmaceuticals Inc                          | ORIC PHARMACEUTI                                 | CUSIP: 68622P109<br>LEI: 54930033FJRNEYBW0L25 | Long             | EC               | CORP              | US        |    110973 | NS      | $906649.41     | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| West Pharmaceutical Services Inc                  | WEST PHARMACEUT                                  | CUSIP: 955306105<br>LEI: 5493007NKRGM1RJQ1P16 | Long             | EC               | CORP              | US        |    226816 | NS      | $47824153.60   | 0.27%             |  |  |  | No            |                  1 | On Loan: No      |
| Alkermes PLC                                      | ALKERMES PLC                                     | CUSIP: G01767105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    482037 | NS      | $14755152.57   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| BrightSpring Health Services Inc                  | BRIGHTSPRING HEA                                 | CUSIP: 10950A106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    191642 | NS      | $4562996.02    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| McKesson Corp                                     | MCKESSON CORP                                    | CUSIP: 58155Q103<br>LEI: 549300WZWOM80UCFSF54 | Long             | EC               | CORP              | US        |    397735 | NS      | $286174309.85  | 1.64%             |  |  |  | No            |                  1 | On Loan: No      |
| Edwards Lifesciences Corp                         | EDWARDS LIFE                                     | CUSIP: 28176E108<br>LEI: YA13X31F3V31L8TMPR58 | Long             | EC               | CORP              | US        |   1847741 | NS      | $144530301.02  | 0.83%             |  |  |  | No            |                  1 | On Loan: No      |
| Astrana Health Inc                                | ASTRANA HEALTH I                                 | CUSIP: 03763A207<br>LEI: 5493008O4R82Q4STJ936 | Long             | EC               | CORP              | US        |    141385 | NS      | $3504934.15    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Vericel Corp                                      | VERICEL CORP                                     | CUSIP: 92346J108<br>LEI: 54930076YM3PLTDR4B91 | Long             | EC               | CORP              | US        |    154233 | NS      | $6369051.74    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Treace Medical Concepts Inc                       | TREACE MEDICAL C                                 | CUSIP: 89455T109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    156458 | NS      | $898068.92     | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Clover Health Investments Corp                    | CLOVER HEALTH IN                                 | CUSIP: 18914F103<br>LEI: 5493000HLYOYQU6LK133 | Long             | EC               | CORP              | US        |   1230230 | NS      | $3862922.20    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| ADMA Biologics Inc                                | ADMA BIOLOGICS INC                               | CUSIP: 000899104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    740413 | NS      | $14689793.92   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| OmniAb Inc                                        | OMNIAB INC - 15                                  | CUSIP: 68218J301<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     22076 | NS      | $0.22          | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| Geron Corp                                        | GERON CORP                                       | CUSIP: 374163103<br>LEI: 549300T282D7Z2YESL90 | Long             | EC               | CORP              | US        |   1611233 | NS      | $2449074.16    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Supernus Pharmaceuticals Inc                      | SUPERNUS PHARMAC                                 | CUSIP: 868459108<br>LEI: 549300GRM36VBKISYJ58 | Long             | EC               | CORP              | US        |    173510 | NS      | $5500267.00    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                               | Receive JOHNSON&JOHNSON Pay Overnight Rate       | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | N/A       |    100000 | NC      | $560001.00     | 0.00%             |  |  |  | No            |                  2 | On Loan: No      |
| N/A                                               | Receive JOHNSON&JOHNSON Pay Overnight Rate +0.75 | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | N/A       |    850000 | NC      | $-934991.50    | -0.01%            |  |  |  | No            |                  2 | On Loan: No      |
| Zymeworks Inc                                     | ZYMEWORKS INC                                    | CUSIP: 98985Y108<br>LEI: 894500AHOYAGYLYZJL67 | Long             | EC               | CORP              | US        |    130122 | NS      | $1487294.46    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| SI-BONE Inc                                       | SI-BONE INC                                      | CUSIP: 825704109<br>LEI: 549300J8JGYVJJHV9C31 | Long             | EC               | CORP              | US        |    117505 | NS      | $2220844.50    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Humacyte Inc                                      | HUMACYTE INC                                     | CUSIP: 44486Q103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    385212 | NS      | $1028516.04    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Molina Healthcare Inc                             | MOLINA HEALTHCAR                                 | CUSIP: 60855R100<br>LEI: 549300NQQCEQ46YHZ591 | Long             | EC               | CORP              | US        |    179211 | NS      | $54666523.44   | 0.31%             |  |  |  | No            |                  1 | On Loan: No      |
| Y-mAbs Therapeutics Inc                           | Y-MABS THERAPEUT                                 | CUSIP: 984241109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     96999 | NS      | $446195.40     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| iRhythm Technologies Inc                          | IRHYTHM TECHNOLO                                 | CUSIP: 450056106<br>LEI: 549300FJI72RJGDQS384 | Long             | EC               | CORP              | US        |     98227 | NS      | $13800893.50   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Kura Oncology Inc                                 | KURA ONCOLOGY IN                                 | CUSIP: 50127T109<br>LEI: 5493005QORQTZCZYOP39 | Long             | EC               | CORP              | US        |    144893 | NS      | $824441.17     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| CONMED Corp                                       | CONMED CORP                                      | CUSIP: 207410101<br>LEI: Z6C0YCECH9DCU5ZIQW84 | Long             | EC               | CORP              | US        |     96573 | NS      | $5480517.75    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Vertex Pharmaceuticals Inc                        | VERTEX PHARM                                     | CUSIP: 92532F100<br>LEI: 54930015RAQRRZ5ZGJ91 | Long             | EC               | CORP              | US        |    806805 | NS      | $356648150.25  | 2.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Danaher Corp                                      | DANAHER CORP                                     | CUSIP: 235851102<br>LEI: S4BKK9OTCEWQ3YHPFM11 | Long             | EC               | CORP              | US        |   2036643 | NS      | $386758505.70  | 2.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Glaukos Corp                                      | GLAUKOS CORP                                     | CUSIP: 377322102<br>LEI: 5299004JA1LHE21M6T14 | Long             | EC               | CORP              | US        |    172681 | NS      | $16282091.49   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Castle Biosciences Inc                            | CASTLE BIOSCIENC                                 | CUSIP: 14843C105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     88037 | NS      | $1405950.89    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Cerus Corp                                        | CERUS CORP                                       | CUSIP: 157085101<br>LEI: 254900BIEY9XIDA04Q21 | Long             | EC               | CORP              | US        |    590108 | NS      | $749437.16     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| ImmunityBio Inc                                   | IMMUNITYBIO INC                                  | CUSIP: 45256X103<br>LEI: 529900J9XLBR4HFL4B83 | Long             | EC               | CORP              | US        |    666023 | NS      | $1771621.18    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Waystar Holding Corp                              | WAYSTAR HOLDING                                  | CUSIP: 946784105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    215539 | NS      | $8617249.22    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Natera Inc                                        | NATERA INC                                       | CUSIP: 632307104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    392789 | NS      | $61954608.97   | 0.36%             |  |  |  | No            |                  1 | On Loan: No      |
| AMN Healthcare Services Inc                       | AMN HEALTHCARE                                   | CUSIP: 001744101<br>LEI: 529900W3ARRTCNFH2I39 | Long             | EC               | CORP              | US        |    119763 | NS      | $2528196.93    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Quanterix Corp                                    | QUANTERIX CORP                                   | CUSIP: 74766Q101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    109162 | NS      | $567642.40     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Cogent Biosciences Inc                            | COGENT BIOSCIENC                                 | CUSIP: 19240Q201<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    225892 | NS      | $1228852.48    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Royalty Pharma PLC                                | ROYALTY PHARMA-A                                 | CUSIP: G7709Q104<br>LEI: 549300FGFN7VOK8BZR03 | Long             | EC               | CORP              | US        |   1182431 | NS      | $38878331.28   | 0.22%             |  |  |  | No            |                  1 | On Loan: No      |
| Liquidia Corp                                     | LIQUIDIA CORP                                    | CUSIP: 53635D202<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    159852 | NS      | $2384991.84    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Integer Holdings Corp                             | INTEGER HOLDINGS                                 | CUSIP: 45826H109<br>LEI: 549300SUD2ED5XG6X569 | Long             | EC               | CORP              | US        |    104954 | NS      | $12464337.04   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                               | Receive JOHNSON&JOHNSON Pay Overnight Rate +0.75 | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | N/A       |    150000 | NC      | $-164998.50    | -0.00%            |  |  |  | No            |                  2 | On Loan: No      |
| Exact Sciences Corp                               | EXACT SCIENCES                                   | CUSIP: 30063P105<br>LEI: 549300VM3X1FYD4N9Z14 | Long             | EC               | CORP              | US        |    579413 | NS      | $32609363.64   | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| Brookdale Senior Living Inc                       | BROOKDALE SR                                     | CUSIP: 112463104<br>LEI: LH7MQB13NWY7CJ9VC445 | Long             | EC               | CORP              | US        |    589812 | NS      | $3839676.12    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| PTC Therapeutics Inc                              | PTC THERAPEUTICS                                 | CUSIP: 69366J200<br>LEI: 549300UJLWOIWFDGB318 | Long             | EC               | CORP              | US        |    217277 | NS      | $10542280.04   | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| MacroGenics Inc                                   | MACROGENICS INC                                  | CUSIP: 556099109<br>LEI: 5493001KJQUA83L8MH79 | Long             | EC               | CORP              | US        |    129079 | NS      | $175547.44     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Atea Pharmaceuticals Inc                          | ATEA PHARMACEUTI                                 | CUSIP: 04683R106<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    184532 | NS      | $548060.04     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| AtriCure Inc                                      | ATRICURE INC                                     | CUSIP: 04963C209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    153256 | NS      | $5298059.92    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Acadia Healthcare Co Inc                          | ACADIA HEALTHCAR                                 | CUSIP: 00404A109<br>LEI: 5493005CW985Y9D0NC11 | Long             | EC               | CORP              | US        |    291793 | NS      | $6606193.52    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Denali Therapeutics Inc                           | DENALI THERAPEUT                                 | CUSIP: 24823R105<br>LEI: 549300ZTQ2HO18L3Q830 | Long             | EC               | CORP              | US        |    404379 | NS      | $5353977.96    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Neumora Therapeutics Inc                          | NEUMORA THERAPEU                                 | CUSIP: 640979100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    176246 | NS      | $126245.01     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Apellis Pharmaceuticals Inc                       | APELLIS PHARMACE                                 | CUSIP: 03753U106<br>LEI: 254900HS0ZFRXXSB9D42 | Long             | EC               | CORP              | US        |    215033 | NS      | $3640508.69    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Establishment Labs Holdings Inc                   | ESTABLISHMENT LA                                 | CUSIP: G31249108<br>LEI: 549300BCBQ714JNJ7V58 | Long             | EC               | CORP              | US        |     63301 | NS      | $2178820.42    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Agios Pharmaceuticals Inc                         | AGIOS PHARMACEUT                                 | CUSIP: 00847X104<br>LEI: 529900ONJHY8EOGYT555 | Long             | EC               | CORP              | US        |    161142 | NS      | $5171046.78    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| IDEXX Laboratories Inc                            | IDEXX LABS                                       | CUSIP: 45168D104<br>LEI: OGMTXK0LUU1HKV2P0J84 | Long             | EC               | CORP              | US        |    256599 | NS      | $131727662.64  | 0.76%             |  |  |  | No            |                  1 | On Loan: No      |
| Cooper Cos Inc/The                                | COOPER COS INC                                   | CUSIP: 216648501<br>LEI: QJKMVPIGLH7530PCUE20 | Long             | EC               | CORP              | US        |    625120 | NS      | $42683193.60   | 0.24%             |  |  |  | No            |                  1 | On Loan: No      |
| Vera Therapeutics Inc                             | VERA THERAPEUTIC                                 | CUSIP: 92337R101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    139355 | NS      | $2640777.25    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Privia Health Group Inc                           | PRIVIA HEALTH GR                                 | CUSIP: 74276R102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    301212 | NS      | $6855585.12    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Becton Dickinson & Co                             | BECTON DICKINSON                                 | CUSIP: 075887109<br>LEI: ICE2EP6D98PQUILVRZ91 | Long             | EC               | CORP              | US        |    908709 | NS      | $156834086.31  | 0.90%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                               | Receive ABBVIE INC Pay Overnight Rate +0.7       | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | N/A       |    300000 | NC      | $-2697000.00   | -0.02%            |  |  |  | No            |                  2 | On Loan: No      |
| Alnylam Pharmaceuticals Inc                       | ALNYLAM PHARMACE                                 | CUSIP: 02043Q107<br>LEI: 529900S3ZI14OWRJII50 | Long             | EC               | CORP              | US        |    404127 | NS      | $123080919.12  | 0.71%             |  |  |  | No            |                  1 | On Loan: No      |
| Intellia Therapeutics Inc                         | INTELLIA THERAPE                                 | CUSIP: 45826J105<br>LEI: 5493002T5BCPE5DZC723 | Long             | EC               | CORP              | US        |    303474 | NS      | $2084866.38    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Multiplan Corp                                    | CLARITEV CORP                                    | CUSIP: 62548M209<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     20363 | NS      | $782957.35     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| DocGo Inc                                         | DOCGO INC                                        | CUSIP: 256086109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    269804 | NS      | $383121.68     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Vaxcyte Inc                                       | VAXCYTE INC                                      | CUSIP: 92243G108<br>LEI: 254900M7NMHTGASX8D95 | Long             | EC               | CORP              | US        |    351292 | NS      | $11413477.08   | 0.07%             |  |  |  | No            |                  1 | On Loan: No      |
| Novocure Ltd                                      | NOVOCURE LTD                                     | CUSIP: G6674U108<br>LEI: 213800YPP55UMHWA4826 | Long             | EC               | CORP              | US        |    321618 | NS      | $6146119.98    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| CVS Health Corp                                   | CVS HEALTH CORP                                  | CUSIP: 126650100<br>LEI: 549300EJG376EN5NQE29 | Long             | EC               | CORP              | US        |   3942329 | NS      | $252466749.16  | 1.45%             |  |  |  | No            |                  1 | On Loan: No      |
| Ideaya Biosciences Inc                            | IDEAYA BIOSCIENC                                 | CUSIP: 45166A102<br>LEI: 549300ULW08F62IJML11 | Long             | EC               | CORP              | US        |    244814 | NS      | $4869350.46    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Cassava Sciences Inc                              | CASSAVA SCIENCES                                 | CUSIP: 14817C107<br>LEI: 529900XA0UG5JXABYF08 | Long             | EC               | CORP              | US        |    142973 | NS      | $287375.73     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Lexicon Pharmaceuticals Inc                       | LEXICON PHARMACE                                 | CUSIP: 528872302<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    569688 | NS      | $356966.50     | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| Corcept Therapeutics Inc                          | CORCEPT THERA                                    | CUSIP: 218352102<br>LEI: 529900EO9LUTFMZ7FF90 | Long             | EC               | CORP              | US        |    295686 | NS      | $22933406.16   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Mineralys Therapeutics Inc                        | MINERALYS THERAP                                 | CUSIP: 603170101<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     97577 | NS      | $1520249.66    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Beam Therapeutics Inc                             | BEAM THERAPEUTIC                                 | CUSIP: 07373V105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    279831 | NS      | $4429724.73    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Universal Health Services Inc                     | UNIVERSAL HLTH-B                                 | CUSIP: 913903100<br>LEI: 549300YGMGQDO0NMJD09 | Long             | EC               | CORP              | US        |    183803 | NS      | $34986901.05   | 0.20%             |  |  |  | No            |                  1 | On Loan: No      |
| Janux Therapeutics Inc                            | JANUX THERAPEUTI                                 | CUSIP: 47103J105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    129008 | NS      | $3070390.40    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Pacira BioSciences Inc                            | PACIRA BIOSCIENC                                 | CUSIP: 695127100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    144864 | NS      | $3743285.76    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| GRAIL Inc                                         | GRAIL INC                                        | CUSIP: 384747101<br>LEI: 2549009XSNESW3VE8024 | Long             | EC               | CORP              | US        |     95050 | NS      | $3650870.50    | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| HealthStream Inc                                  | HEALTHSTREAM INC                                 | CUSIP: 42222N103<br>LEI: 529900OJ88H8635JNH64 | Long             | EC               | CORP              | US        |     76656 | NS      | $2147901.12    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Veeva Systems Inc                                 | VEEVA SYSTEMS-A                                  | CUSIP: 922475108<br>LEI: 549300YZEXPDB92M2F02 | Long             | EC               | CORP              | US        |    483235 | NS      | $135160829.50  | 0.77%             |  |  |  | No            |                  1 | On Loan: No      |
| Xenon Pharmaceuticals Inc                         | XENON PHARMACEUT                                 | CUSIP: 98420N105<br>LEI: 549300XV44Q9Z1MIPQ03 | Long             | EC               | CORP              | US        |    202293 | NS      | $5836153.05    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Centene Corp                                      | CENTENE CORP                                     | CUSIP: 15135B101<br>LEI: 549300Z7JJ4TQSQGT333 | Long             | EC               | CORP              | US        |   1582004 | NS      | $89288305.76   | 0.51%             |  |  |  | No            |                  1 | On Loan: No      |
| Altimmune Inc                                     | ALTIMMUNE INC                                    | CUSIP: 02155H200<br>LEI: 549300EOYCQ8SW3NVE64 | Long             | EC               | CORP              | US        |    224100 | NS      | $1216863.00    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Guardant Health Inc                               | GUARDANT HEALTH                                  | CUSIP: 40131M109<br>LEI: 254900M8C3E5VC8BR186 | Long             | EC               | CORP              | US        |    387030 | NS      | $15721158.60   | 0.09%             |  |  |  | No            |                  1 | On Loan: No      |
| Viridian Therapeutics Inc                         | VIRIDIAN THERAPE                                 | CUSIP: 92790C104<br>LEI: 549300C775BNYF550E70 | Long             | EC               | CORP              | US        |    174332 | NS      | $2426701.44    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Moderna Inc                                       | MODERNA INC                                      | CUSIP: 60770K107<br>LEI: 549300EI6OKH5K5Q2G38 | Long             | EC               | CORP              | US        |   1025747 | NS      | $27243840.32   | 0.16%             |  |  |  | No            |                  1 | On Loan: No      |
| Cardinal Health Inc                               | CARDINAL HEALTH                                  | CUSIP: 14149Y108<br>LEI: CCU46N3GJMF4OK4N7U60 | Long             | EC               | CORP              | US        |    758343 | NS      | $117118492.92  | 0.67%             |  |  |  | No            |                  1 | On Loan: No      |
| Viatris Inc                                       | VIATRIS INC                                      | CUSIP: 92556V106<br>LEI: 254900ZZTSW7NL773X71 | Long             | EC               | CORP              | US        |   3735367 | NS      | $32833875.93   | 0.19%             |  |  |  | No            |                  1 | On Loan: No      |
| STERIS PLC                                        | STERIS PLC                                       | CUSIP: G8473T100<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    309271 | NS      | $75836341.91   | 0.43%             |  |  |  | No            |                  1 | On Loan: No      |
| Select Medical Holdings Corp                      | SELECT MEDICAL                                   | CUSIP: 81619Q105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    345208 | NS      | $5278230.32    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| RxSight Inc                                       | RXSIGHT INC                                      | CUSIP: 78349D107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    107829 | NS      | $1648705.41    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Lyell Immunopharma Inc                            | LYELL IMMUNOPHAR                                 | CUSIP: 55083R104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    344888 | NS      | $150612.59     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Mettler-Toledo International Inc                  | METTLER-TOLEDO                                   | CUSIP: 592688105<br>LEI: 5493000BD5GJNUDIUG10 | Long             | EC               | CORP              | US        |     66094 | NS      | $76372938.88   | 0.44%             |  |  |  | No            |                  1 | On Loan: No      |
| Bio-Techne Corp                                   | BIO-TECHNE CORP                                  | CUSIP: 09073M104<br>LEI: 54930073RLKQ51TILZ35 | Long             | EC               | CORP              | US        |    498174 | NS      | $24111621.60   | 0.14%             |  |  |  | No            |                  1 | On Loan: No      |
| Definitive Healthcare Corp                        | DEFINITIVE HEALT                                 | CUSIP: 24477E103<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    146508 | NS      | $484941.48     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Ocular Therapeutix Inc                            | OCULAR THERAPEUT                                 | CUSIP: 67576A100<br>LEI: 529900ABAWFXOHSIHG03 | Long             | EC               | CORP              | US        |    294795 | NS      | $2361307.95    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Insmed Inc                                        | INSMED INC                                       | CUSIP: 457669307<br>LEI: 529900Q55QAG41CCAC11 | Long             | EC               | CORP              | US        |    532033 | NS      | $37098661.09   | 0.21%             |  |  |  | No            |                  1 | On Loan: No      |
| Humana Inc                                        | HUMANA INC                                       | CUSIP: 444859102<br>LEI: 529900YLDW34GJAO4J06 | Long             | EC               | CORP              | US        |    377309 | NS      | $87962047.17   | 0.50%             |  |  |  | No            |                  1 | On Loan: No      |
| Syndax Pharmaceuticals Inc                        | SYNDAX PHARMACEU                                 | CUSIP: 87164F105<br>LEI: 529900OF94TRHKZVBS87 | Long             | EC               | CORP              | US        |    241391 | NS      | $2544261.14    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| ALX Oncology Holdings Inc                         | ALX ONCOLOGY HOL                                 | CUSIP: 00166B105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     79379 | NS      | $38538.50      | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| MannKind Corp                                     | MANNKIND CORP                                    | CUSIP: 56400P706<br>LEI: 213800GFBCNY1ZFST722 | Long             | EC               | CORP              | US        |    865609 | NS      | $3592277.35    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Fortrea Holdings Inc                              | FORTREA HOLDINGS                                 | CUSIP: 34965K107<br>LEI: 5493000FIVFABOVCDU97 | Long             | EC               | CORP              | US        |    268318 | NS      | $1153767.40    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Gilead Sciences Inc                               | GILEAD SCIENCES                                  | CUSIP: 375558103<br>LEI: 549300WTZWR07K8MNV44 | Long             | EC               | CORP              | US        |   3904621 | NS      | $429820679.68  | 2.46%             |  |  |  | No            |                  1 | On Loan: No      |
| Travere Therapeutics Inc                          | TRAVERE THERAPEU                                 | CUSIP: 89422G107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    256356 | NS      | $3850467.12    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| ICU Medical Inc                                   | ICU MEDICAL                                      | CUSIP: 44930G107<br>LEI: 5493003NRW7LS2QZRH60 | Long             | EC               | CORP              | US        |     72751 | NS      | $9811199.86    | 0.06%             |  |  |  | No            |                  1 | On Loan: No      |
| UFP Technologies Inc                              | UFP TECHNOLOGIES                                 | CUSIP: 902673102<br>LEI: 549300RJ8LY41HS70C91 | Long             | EC               | CORP              | US        |     23964 | NS      | $5612368.80    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Merus NV                                          | MERUS NV                                         | CUSIP: N5749R100<br>LEI: 549300W8GPUWU8QNU293 | Long             | EC               | CORP              | US        |    150254 | NS      | $8424741.78    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| UnitedHealth Group Inc                            | UNITEDHEALTH GRP                                 | CUSIP: 91324P102<br>LEI: 549300GHBMY8T5GXDE41 | Long             | EC               | CORP              | US        |   2883284 | NS      | $870492272.44  | 4.99%             |  |  |  | No            |                  1 | On Loan: No      |
| Annexon Inc                                       | ANNEXON INC                                      | CUSIP: 03589W102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    216130 | NS      | $440905.20     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Concentra Group Holdings Parent Inc               | CONCENTRA GROUP                                  | CUSIP: 20603L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    357486 | NS      | $7732422.18    | 0.04%             |  |  |  | No            |                  1 | On Loan: No      |
| Novavax Inc                                       | NOVAVAX INC                                      | CUSIP: 670002401<br>LEI: 529900J4GJHPEPQ23205 | Long             | EC               | CORP              | US        |    452995 | NS      | $3324983.30    | 0.02%             |  |  |  | No            |                  1 | On Loan: —       |
| Rapport Therapeutics Inc                          | RAPPORT THERAPEU                                 | CUSIP: 75383L102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     51798 | NS      | $428369.46     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Viking Therapeutics Inc                           | VIKING THERAPEUT                                 | CUSIP: 92686J106<br>LEI: 529900IVC72YPFA25M37 | Long             | EC               | CORP              | US        |    313550 | NS      | $8403140.00    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Ironwood Pharmaceuticals Inc                      | IRONWOOD PHARMAC                                 | CUSIP: 46333X108<br>LEI: 549300PC8MR6QHH6P296 | Long             | EC               | CORP              | US        |    453002 | NS      | $271393.50     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| Cross Country Healthcare Inc                      | CROSS COUNTRY HE                                 | CUSIP: 227483104<br>LEI: 54930037L0NBIPZ5S663 | Long             | EC               | CORP              | US        |     91397 | NS      | $1204612.46    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| iTeos Therapeutics Inc                            | ITEOS THERAPEUTI                                 | CUSIP: 46565G104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     77248 | NS      | $774024.96     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| N/A                                               | Receive GLOBUS MEDICAL I Pay Overnight Rate      | CUSIP: N/A<br>LEI: N/A                        | N/A              | DE               |  | N/A       |    100000 | NC      | $-1259000.00   | -0.01%            |  |  |  | No            |                  2 | On Loan: No      |
| Repligen Corp                                     | REPLIGEN CORP                                    | CUSIP: 759916109<br>LEI: 54930006QJ0T5AUO1E71 | Long             | EC               | CORP              | US        |    166887 | NS      | $19704348.09   | 0.11%             |  |  |  | No            |                  1 | On Loan: No      |
| Aurinia Pharmaceuticals Inc                       | AURINIA PHARMACE                                 | CUSIP: 05156V102<br>LEI: 5299008YP2BW4570ML28 | Long             | EC               | CORP              | US        |    382361 | NS      | $2997710.24    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| LeMaitre Vascular Inc                             | LEMAITRE VASCULA                                 | CUSIP: 525558201<br>LEI: 549300FZUBUB7MHY8R17 | Long             | EC               | CORP              | US        |     63149 | NS      | $5190847.80    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |
| Neogen Corp                                       | NEOGEN CORP                                      | CUSIP: 640491106<br>LEI: 549300HJT9FC36N4UW43 | Long             | EC               | CORP              | US        |    647601 | NS      | $3794941.86    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Alphatec Holdings Inc                             | ALPHATEC HOLDING                                 | CUSIP: 02081G201<br>LEI: 549300EZE8CQ8K65FS24 | Long             | EC               | CORP              | US        |    331936 | NS      | $4125964.48    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Cencora Inc                                       | CENCORA INC                                      | CUSIP: 03073E105<br>LEI: AI8GXW8LG5WK7E9UD086 | Long             | EC               | CORP              | US        |    544997 | NS      | $158724926.28  | 0.91%             |  |  |  | No            |                  1 | On Loan: No      |
| Insulet Corp                                      | INSULET CORP                                     | CUSIP: 45784P101<br>LEI: 549300TZTYD2PYN92D43 | Long             | EC               | CORP              | US        |    219707 | NS      | $71411366.21   | 0.41%             |  |  |  | No            |                  1 | On Loan: No      |
| Vir Biotechnology Inc                             | VIR BIOTECHNOLOG                                 | CUSIP: 92764N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    279039 | NS      | $1378452.66    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Johnson & Johnson                                 | JOHNSON&JOHNSON                                  | CUSIP: 478160104<br>LEI: 549300G0CFPGEF6X2043 | Long             | EC               | CORP              | US        |   5293692 | NS      | $821633935.32  | 4.71%             |  |  |  | No            |                  1 | On Loan: No      |
| Merit Medical Systems Inc                         | MERIT MEDICAL                                    | CUSIP: 589889104<br>LEI: 549300OYTY138SP2CE83 | Long             | EC               | CORP              | US        |    182797 | NS      | $17371198.91   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Bio-Rad Laboratories Inc                          | BIO-RAD LABS-A                                   | CUSIP: 090572207<br>LEI: 549300ZC1GPV35XYDK53 | Long             | EC               | CORP              | US        |     60990 | NS      | $13840460.70   | 0.08%             |  |  |  | No            |                  1 | On Loan: No      |
| Integra LifeSciences Holdings Corp                | INTEGRA LIFESCIE                                 | CUSIP: 457985208<br>LEI: WB7IJCYY8YFTENS4O147 | Long             | EC               | CORP              | US        |    218240 | NS      | $2762918.40    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| OrthoPediatrics Corp                              | ORTHOPEDIATRICS                                  | CUSIP: 68752L100<br>LEI: 5493000KUTPFGOPAT717 | Long             | EC               | CORP              | US        |     49476 | NS      | $987540.96     | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Schrodinger Inc/United States                     | SCHRODINGER INC                                  | CUSIP: 80810D103<br>LEI: 984500044BAE4791E559 | Long             | EC               | CORP              | US        |    198418 | NS      | $4289797.16    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Monte Rosa Therapeutics Inc                       | MONTE ROSA THERA                                 | CUSIP: 61225M102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    125671 | NS      | $525304.78     | 0.00%             |  |  |  | No            |                  1 | On Loan: No      |
| MoonLake Immunotherapeutics                       | MOONLAKE IMMUNOT                                 | CUSIP: 61559X104<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     68568 | NS      | $2674837.68    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Arcturus Therapeutics Holdings Inc                | ARCTURUS THERAPE                                 | CUSIP: 03969T109<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     76918 | NS      | $963782.54     | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Amneal Pharmaceuticals Inc                        | AMNEAL PHARM INC                                 | CUSIP: 03168L105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    438076 | NS      | $3206716.32    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| REGENXBIO Inc                                     | REGENXBIO INC                                    | CUSIP: 75901B107<br>LEI: 549300EOES47LATSET33 | Long             | EC               | CORP              | US        |    131790 | NS      | $1166341.50    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Phathom Pharmaceuticals Inc                       | PHATHOM PHARMACE                                 | CUSIP: 71722W107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    118271 | NS      | $502651.75     | 0.00%             |  |  |  | No            |                  1 | On Loan: —       |
| SpringWorks Therapeutics Inc                      | SPRINGWORKS THER                                 | CUSIP: 85205L107<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    185828 | NS      | $8680025.88    | 0.05%             |  |  |  | No            |                  1 | On Loan: No      |
| Chinook Therapeutics Inc                          | CHINOOK THERAPEUTICS INC - CVR (AUG 2023)        | CUSIP: N/A<br>LEI: 549300X0O3003W5QYQ48       | Long             | EC               | CORP              | US        |       784 | NS      | $0.00          | 0.00%             |  |  |  | No            |                  3 | On Loan: No      |
| ArriVent Biopharma Inc                            | ARRIVENT BIOPHAR                                 | CUSIP: 04272N102<br>LEI: N/A                  | Long             | EC               | CORP              | US        |     42214 | NS      | $897047.50     | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Fulgent Genetics Inc                              | FULGENT GENETICS                                 | CUSIP: 359664109<br>LEI: 549300CL6P01M68QJ404 | Long             | EC               | CORP              | US        |     61639 | NS      | $1277160.08    | 0.01%             |  |  |  | No            |                  1 | On Loan: No      |
| Masimo Corp                                       | MASIMO CORP                                      | CUSIP: 574795100<br>LEI: 549300Q4A8JK0PIYCU29 | Long             | EC               | CORP              | US        |    142720 | NS      | $23192000.00   | 0.13%             |  |  |  | No            |                  1 | On Loan: No      |
| Dynavax Technologies Corp                         | DYNAVAX TECHNOLO                                 | CUSIP: 268158201<br>LEI: 549300T5URIXWDILX594 | Long             | EC               | CORP              | US        |    371531 | NS      | $3637288.49    | 0.02%             |  |  |  | No            |                  1 | On Loan: No      |
| Labcorp Holdings Inc                              | LABCORP HOLDINGS                                 | CUSIP: 504922105<br>LEI: N/A                  | Long             | EC               | CORP              | US        |    261993 | NS      | $65228397.21   | 0.37%             |  |  |  | No            |                  1 | On Loan: No      |
| REVOLUTION Medicines Inc                          | REVOLUTION MEDIC                                 | CUSIP: 76155X100<br>LEI: 549300JU3X0LBCQ65892 | Long             | EC               | CORP              | US        |    446987 | NS      | $17611287.80   | 0.10%             |  |  |  | No            |                  1 | On Loan: No      |
| Tilray Brands Inc                                 | TILRAY BRANDS IN                                 | CUSIP: 88688T100<br>LEI: 549300Y4V60733TO1478 | Long             | EC               | CORP              | US        |   2949377 | NS      | $1255549.79    | 0.01%             |  |  |  | No            |                  1 | On Loan: —       |
| Omnicell Inc                                      | OMNICELL INC                                     | CUSIP: 68213N109<br>LEI: 5493008RH0GTKHHPZI77 | Long             | EC               | CORP              | US        |    144532 | NS      | $4389436.84    | 0.03%             |  |  |  | No            |                  1 | On Loan: No      |

### Signature

**Date Signed:** 2025-07-29

**Name of Applicant:** VANGUARD WORLD FUND

**Signature:** Ashley Grim

**Name of Signer:** Ashley Grim

**Title:** Treasurer