# EDGAR Filing Document

**Accession Number:** 0001395064
**File Stem:** 0001395064-25-000120
**Filing Date:** 2025-7
**Character Count:** 162033
**Document Hash:** 218aa45ee2d95914020c136f88ad54b8
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001395064-25-000120.hdr.sgml**: 20250730

**ACCESSION NUMBER**: 0001395064-25-000120

**CONFORMED SUBMISSION TYPE**: 6-K

**PUBLIC DOCUMENT COUNT**: 3

**CONFORMED PERIOD OF REPORT**: 20250730

**FILED AS OF DATE**: 20250730

**DATE AS OF CHANGE**: 20250730

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** TAKEDA PHARMACEUTICAL CO LTD
- **CENTRAL INDEX KEY:** 0001395064
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000

**FILING VALUES:**
- **FORM TYPE:** 6-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-38757
- **FILM NUMBER:** 251163822

**BUSINESS ADDRESS:**
- **STREET 1:** 1-1, NIHONBASHI-HONCHO 2-CHOME, CHUO-KU
- **CITY:** TOKYO
- **STATE:** M0
- **ZIP:** 103-8668
- **BUSINESS PHONE:** 81332782111

**MAIL ADDRESS:**
- **STREET 1:** 1-1, NIHONBASHI-HONCHO 2-CHOME, CHUO-KU
- **CITY:** TOKYO
- **STATE:** M0
- **ZIP:** 103-8668

**FORM 6-K**

**U.S. SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**Report of Foreign Private Issuer**

**Pursuant to Rule 13a-16 or 15d-16 of**

**the Securities Exchange Act of 1934**

**Commission File Number: 001-38757**

**For the month of July 2025**

**TAKEDA PHARMACEUTICAL COMPANY LIMITED**

**(Translation of registrant's name into English)**

**1-1, Nihonbashi-Honcho 2-Chome**

**Chuo-ku, Tokyo 103-8668**

**Japan**

**(Address of principal executive offices)**

Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.

Form 20-F ☒&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Form 40-F ☐

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1): ☐

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7): ☐

------

Information furnished on this form:

**EXHIBIT**

---

| | |
|:---|:---|
| Exhibit<br>Number |  |
| 1. | <u>[(English Translation) Earnings Report (Kessan Tanshin) for the Three-month Period Ended June 30, 2025](#i8e9b32f40a9848fba7c1ad0404c901a5_10)</u> |
| 99.1 | <u>[Financial Appendix](exhibit991_073025.htm)</u> |

---

------

**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

---

| | | |
|:---|:---|:---|
| | **TAKEDA PHARMACEUTICAL COMPANY LIMITED** | **TAKEDA PHARMACEUTICAL COMPANY LIMITED** |
| Date: July 30, 2025 | By: | /s/ Norimasa Takeda |
|  |  | Norimasa Takeda<br>Chief Accounting Officer and Corporate Controller |

---

------

**Earnings Report (*Kessan Tanshin*) for the Three-month Period Ended June 30, 2025 (IFRS, Consolidated)**

July 30, 2025

---

| | | | |
|:---|:---|:---|:---|
| **Takeda Pharmaceutical Company Limited** | **Takeda Pharmaceutical Company Limited** | Stock exchange listings: | Tokyo, Nagoya, Sapporo, Fukuoka |
| TSE Code: | 4502 | URL: https://www.takeda.com |  |
| Representative: | Christophe Weber, President & CEO |  |  |
| Contact: | Christopher O'Reilly | Telephone: +81-3-3278-2111 | Email: takeda.ir.contact@takeda.com |
|  | Global Head of IR, Global Finance |  |  |

---

---

| |
|:---|
| Scheduled date of dividend payment commencement: - |
| Supplementary materials for the financial statements: Yes |
| Presentation to explain the financial statements: Yes |

---

(Million JPY, rounded to the nearest million)

**1.** **Consolidated Financial Results for the Three-month Period Ended June 30, 2025 (April 1 to June 30, 2025)**

&nbsp;&nbsp;&nbsp;&nbsp;(1)Consolidated Operating Results (year to date)

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | (Percentage figures represent changes over the same period of the previous year) | (Percentage figures represent changes over the same period of the previous year) | (Percentage figures represent changes over the same period of the previous year) | (Percentage figures represent changes over the same period of the previous year) | (Percentage figures represent changes over the same period of the previous year) | (Percentage figures represent changes over the same period of the previous year) | (Percentage figures represent changes over the same period of the previous year) | (Percentage figures represent changes over the same period of the previous year) |
| | Revenue | Revenue | Operating profit | Operating profit | Profit before tax | Profit before tax | Net profit<br>for the period | Net profit<br>for the period |
| | (Million JPY) | (%) | (Million JPY) | (%) | (Million JPY) | (%) | (Million JPY) | (%) |
| Three-month Period Ended June 30, 2025 | 1106685 | (8.4) | 184566 | 11.0 | 150630 | 10.3 | 124279 | 30.4 |
| Three-month Period Ended June 30, 2024 | 1207990 | 14.1 | 166329 | (1.3) | 136604 | 1.2 | 95299 | 6.6 |
|  | Net profit attributable to<br>owners of the Company | Net profit attributable to<br>owners of the Company | Total comprehensive<br>income for the period | Total comprehensive<br>income for the period | Basic earnings<br>per share | Basic earnings<br>per share | Diluted earnings<br>per share | Diluted earnings<br>per share |
|  | (Million JPY) | (%) | (Million JPY) | (%) | (JPY) | (JPY) | (JPY) | (JPY) |
| Three-month Period Ended June 30, 2025 | 124243 | 30.4 | 119101 | (82.0) | 79.40 | 79.40 | 78.23 | 78.23 |
| Three-month Period Ended June 30, 2024 | 95248 | 6.5 | 660122 | (4.9) | 60.71 | 60.71 | 59.94 | 59.94 |
|  | Core Operating Profit | Core Operating Profit | Core EPS | Core EPS |  |  |  |  |
|  | (Billion JPY) | (%) | (JPY) | (JPY) |  |  |  |  |
| Three-month Period Ended June 30, 2025 | 321.8 | (15.8) | 151 | 151 |  |  |  |  |
| Three-month Period Ended June 30, 2024 | 382.3 | 17.1 | 176 | 176 |  |  |  |  |

---

&nbsp;&nbsp;&nbsp;&nbsp;(2)Consolidated Financial Position

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | Total assets<br>(Million JPY) | Total equity<br>(Million JPY) | Equity attributable<br>to owners of the<br>Company<br>(Million JPY) | Ratio of equity<br>attributable to<br>owners of the<br>Company to total<br>assets (%) | Equity attributable<br>to owners of the<br>Company per<br>share (JPY) |
| As of June 30, 2025 | 14004537 | 6866179 | 6865259 | 49.0 | 4395.19 |
| As of March 31, 2025 | 14248344 | 6935979 | 6935084 | 48.7 | 4407.01 |

---

------

**2. Dividends**

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | Annual dividends per share (JPY) | Annual dividends per share (JPY) | Annual dividends per share (JPY) | Annual dividends per share (JPY) | Annual dividends per share (JPY) |
| | 1st quarter end | 2nd quarter end | 3rd quarter end | Year-end | Total |
| For the Fiscal Year Ended March 31, 2025 |  | 98.00 |  | 98.00 | 196.00 |
| For the Fiscal Year Ending March 31, 2026 |  |  |  |  |  |
| For the Fiscal Year Ending March 31, 2026 (Projection) |  | 100.00 |  | 100.00 | 200.00 |

---

(Note) Modifications in the dividend projection from the latest announcement: None

**3.** **Forecasts for Consolidated Operating Results (Actual Exchange Rate basis) for the Fiscal Year Ending March 31, 2026 (April 1, 2025 to March 31, 2026)**

---

| | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | (Percentage figures represent changes from the previous fiscal year) | (Percentage figures represent changes from the previous fiscal year) | (Percentage figures represent changes from the previous fiscal year) | (Percentage figures represent changes from the previous fiscal year) | (Percentage figures represent changes from the previous fiscal year) | (Percentage figures represent changes from the previous fiscal year) | (Percentage figures represent changes from the previous fiscal year) | (Percentage figures represent changes from the previous fiscal year) | (Percentage figures represent changes from the previous fiscal year) |
| | Revenue | Revenue | Operating profit | Operating profit | Profit before taxes | Profit before taxes | Net profit attributable to owners of the Company | Net profit attributable to owners of the Company | Basic earnings<br>per share |
| | (Million JPY) | (%) | (Million JPY) | (%) | (Million JPY) | (%) | (Million JPY) | (%) | (JPY) |
| For the Fiscal Year Ending March 31, 2026 | 4530000 | (1.1) | 475000 | 38.7 | 307000 | 75.3 | 228000 | 111.3 | 144.81 |
| (Note) Modifications in forecasts of consolidated operating results from the latest announcement: None | (Note) Modifications in forecasts of consolidated operating results from the latest announcement: None | (Note) Modifications in forecasts of consolidated operating results from the latest announcement: None | (Note) Modifications in forecasts of consolidated operating results from the latest announcement: None | (Note) Modifications in forecasts of consolidated operating results from the latest announcement: None | (Note) Modifications in forecasts of consolidated operating results from the latest announcement: None | (Note) Modifications in forecasts of consolidated operating results from the latest announcement: None |  |  |  |
| Forecasts for Core financial measures are shown below. | Forecasts for Core financial measures are shown below. | Forecasts for Core financial measures are shown below. | Forecasts for Core financial measures are shown below. | Forecasts for Core financial measures are shown below. | Forecasts for Core financial measures are shown below. | Forecasts for Core financial measures are shown below. | Forecasts for Core financial measures are shown below. | Forecasts for Core financial measures are shown below. | Forecasts for Core financial measures are shown below. |
|  | (Percentage figures represent changes from the previous fiscal year) | (Percentage figures represent changes from the previous fiscal year) | (Percentage figures represent changes from the previous fiscal year) | (Percentage figures represent changes from the previous fiscal year) | (Percentage figures represent changes from the previous fiscal year) | (Percentage figures represent changes from the previous fiscal year) |  |  |  |
|  | Core Revenue | Core Revenue | Core Operating Profit | Core Operating Profit | Core EPS | Core EPS |  |  |  |
|  | (Million JPY) | (%) | (Million JPY) | (%) | (JPY) | (JPY) |  |  |  |
| For the Fiscal Year Ending March 31, 2026 | 4530000 | (1.1) | 1140000 | (1.9) | 485 | 485 |  |  |  |

---

(Note) Modifications in forecasts of consolidated operating results from the latest announcement: None

The definition of Core financial measures is stated in "Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations" in the Financial Appendix.

**4.** **Management Guidance (Constant Exchange Rate basis) for the Fiscal Year Ending March 31, 2026 (April 1, 2025 to March 31, 2026)**

Takeda uses change in Core Revenue, Core Operating Profit and Core EPS at Constant Exchange Rate (CER) basis as its Management Guidance. The full year management guidance for the fiscal year ending March 31, 2026 (FY2025) has not been revised from the management guidance announced on May 8, 2025.

---

| | | | |
|:---|:---|:---|:---|
| | Core Revenue Growth<br>(%) | Core Operating Profit Growth<br>(%) | Core EPS Growth<br>(%) |
| For the Fiscal Year Ending March 31, 2026 | Broadly Flat | Broadly Flat | Broadly Flat |

---

The definition of Constant Exchange Rate change is stated in "Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations" in the Financial Appendix.

------

**▪ Additional Information**

---

| | |
|:---|:---|
| (1) Significant changes in the scope of consolidation during the period | : No |
| (2) Changes in accounting policies and changes in accounting estimates |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1) Changes in accounting policies required by IFRS | : No&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2) Changes in accounting policies other than 1) | : No |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3) Changes in accounting estimates | : No |
| (3) Number of shares outstanding (common stock) |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1) Number of shares outstanding (including treasury stock) at period end: |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;June 30, 2025 | 1,590,962,609 shares |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;March 31, 2025 | 1,590,949,609 shares |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2) Number of shares of treasury stock at period end: |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;June 30, 2025 | 28,968,756 shares |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;March 31, 2025 | 17,299,963 shares |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3) Average number of outstanding shares (for the three-month period ended June 30): | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;3) Average number of outstanding shares (for the three-month period ended June 30): |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;June 30, 2025 | 1,564,729,658 shares |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;June 30, 2024 | 1,568,915,479 shares |

---

**▪ Review of the attached condensed interim consolidated financial statements by certified public accountants or an audit firm: No**

**▪ Note to ensure appropriate use of forecasts and guidance, and other noteworthy items**

 • Takeda applies International Financial Reporting Standards (IFRS), and the disclosure information in this document is based on IFRS.

•  All forecasts and management guidance in this document are based on information and assumptions currently available to management, and do not represent a promise or guarantee to achieve these forecasts. Various uncertain factors could cause actual results to differ, such as changes in the business environment and fluctuations in foreign exchange rates. Should any significant event occur which requires the forecasts or guidance to be revised, Takeda will disclose it in a timely manner.

•  For details of the forecasts for consolidated operating results and the management guidance, please refer to "1. Financial Highlights for the Three-month Period Ended June 30, 2025 (3) Outlook for the Fiscal Year Ending March 31, 2026" on page [12](#i8e9b32f40a9848fba7c1ad0404c901a5_25).

 • Supplementary materials for the financial statements including the Quarterly Financial Report and Earnings Presentation of the conference call on July 30, 2025, and its audio will be promptly posted on Takeda's website.

(Takeda Website):

<u>https://www.takeda.com/investors/financial-results/quarterly-results/</u>

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Three-month

Period Ended June 30, 2025 (Consolidated)

 **Attachment Index**

---

| | |
|:---|:---|
| **<u>[1. Financial Highlights for the Three-month Period Ended June 30, 2025](#i8e9b32f40a9848fba7c1ad0404c901a5_16)</u>** | **<u>[2](#i8e9b32f40a9848fba7c1ad0404c901a5_16)</u>** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(1) Business Performance](#i8e9b32f40a9848fba7c1ad0404c901a5_19)</u> | <u>[2](#i8e9b32f40a9848fba7c1ad0404c901a5_19)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(2) Consolidated Financial Position](#i8e9b32f40a9848fba7c1ad0404c901a5_22)</u> | <u>[9](#i8e9b32f40a9848fba7c1ad0404c901a5_22)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(3) Outlook for the Fiscal Year Ending March 31, 2026](#i8e9b32f40a9848fba7c1ad0404c901a5_25)</u> | <u>[12](#i8e9b32f40a9848fba7c1ad0404c901a5_25)</u> |
| **<u>[2. Condensed Interim Consolidated Financial Statements \[IFRS\] and Major Notes](#i8e9b32f40a9848fba7c1ad0404c901a5_31)</u>** | **<u>[14](#i8e9b32f40a9848fba7c1ad0404c901a5_34)</u>** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(1) Condensed Interim Consolidated Statements of Profit or Loss](#i8e9b32f40a9848fba7c1ad0404c901a5_34)</u> | <u>[14](#i8e9b32f40a9848fba7c1ad0404c901a5_34)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(2) Condensed Interim Consolidated Statements of Comprehensive Income](#i8e9b32f40a9848fba7c1ad0404c901a5_37)</u> | <u>[15](#i8e9b32f40a9848fba7c1ad0404c901a5_37)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(3) Condensed Interim Consolidated Statements of Financial Position](#i8e9b32f40a9848fba7c1ad0404c901a5_40)</u> | <u>[16](#i8e9b32f40a9848fba7c1ad0404c901a5_40)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(4) Condensed Interim Consolidated Statements of Changes in Equity](#i8e9b32f40a9848fba7c1ad0404c901a5_43)</u> | <u>[18](#i8e9b32f40a9848fba7c1ad0404c901a5_43)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(5) Condensed Interim Consolidated Statement of Cash Flows](#i8e9b32f40a9848fba7c1ad0404c901a5_46)</u> | <u>[20](#i8e9b32f40a9848fba7c1ad0404c901a5_46)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(6) Notes to Condensed Interim Consolidated Financial Statements](#i8e9b32f40a9848fba7c1ad0404c901a5_49)</u> | <u>[22](#i8e9b32f40a9848fba7c1ad0404c901a5_49)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(Significant Uncertainty Regarding Going Concern Assumption)](#i8e9b32f40a9848fba7c1ad0404c901a5_52)</u> | <u>[22](#i8e9b32f40a9848fba7c1ad0404c901a5_49)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(Material Accounting Policies)](#i8e9b32f40a9848fba7c1ad0404c901a5_55)</u> | <u>[22](#i8e9b32f40a9848fba7c1ad0404c901a5_49)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(Operating Segment Information)](#i8e9b32f40a9848fba7c1ad0404c901a5_955)</u> | <u>[22](#i8e9b32f40a9848fba7c1ad0404c901a5_49)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(Significant Changes in Equity Attributable to Owners of the Company)](#i8e9b32f40a9848fba7c1ad0404c901a5_58)</u> | <u>[22](#i8e9b32f40a9848fba7c1ad0404c901a5_49)</u> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<u>[(Significant Subsequent Events)](#i8e9b32f40a9848fba7c1ad0404c901a5_61)</u> | <u>[22](#i8e9b32f40a9848fba7c1ad0404c901a5_49)</u> |
| **[Financial Appendix]** |  |

---

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Three-month

Period Ended June 30, 2025 (Consolidated)

**1. Financial Highlights for the Three-month Period Ended June 30, 2025**

**(1) Business Performance**

**(i) Consolidated Financial Results (April 1 to June 30, 2025)**

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** |
| | **FY2024 Q1** | **FY2025 Q1** | AER | AER | CER |
| | **FY2024 Q1** | **FY2025 Q1** | JPY Change | % Change | % Change |
| Revenue | 1208.0 | 1106.7 | (101.3) | (8.4)% | (3.7)% |
| Cost of sales | (387.0) | (384.7) | 2.3 | (0.6)% | 4.3% |
| Selling, general and administrative expenses | (270.0) | (255.9) | 14.1 | (5.2)% | (0.0)% |
| Research and development expenses | (168.5) | (143.9) | 24.6 | (14.6)% | (9.7)% |
| Amortization and impairment losses on intangible assets associated with products | (162.8) | (131.6) | 31.2 | (19.2)% | (14.3)% |
| Other operating income | 10.9 | 22.0 | 11.2 | 102.7% | 102.1% |
| Other operating expenses | (64.3) | (28.1) | 36.2 | (56.3)% | (53.6)% |
| Operating profit | 166.3 | 184.6 | 18.2 | 11.0% | 14.0% |
| Finance income and (expenses), net | (29.0) | (33.4) | (4.4) | 15.1% | 15.5% |
| Share of loss of investments accounted for using the equity method | (0.7) | (0.5) | 0.2 | (24.7)% | (69.6)% |
| Profit before tax | 136.6 | 150.6 | 14.0 | 10.3% | 14.1% |
| Income tax expenses | (41.3) | (26.4) | 15.0 | (36.2)% | (32.9)% |
| Net profit for the period | 95.3 | 124.3 | 29.0 | 30.4% | 34.5% |
| Net profit for the period attributable to owners of the Company | 95.2 | 124.2 | 29.0 | 30.4% | 34.5% |

---

In this section, the amount of change and percentage change based on Actual Exchange Rates are presented in "AER" (which is presented in accordance with IFRS) and percentage change based on Constant Exchange Rate (which is a non-IFRS measure) is presented in "CER". For additional information on CER change, see "Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations" in the Financial Appendix.

***Revenue***

Revenue for the three-month period ended June 30, 2025 was JPY 1,106.7 billion (JPY -101.3 billion and -8.4% AER, -3.7% CER). The decline compared to the same period of the previous fiscal year was primarily attributable to unfavorable foreign exchange rates and a decrease in revenue in Neuroscience, one of our six key business areas. The decrease in Neuroscience was largely attributable to the continued impact from generic erosion of VYVANSE (for attention deficit hyperactivity disorder ("ADHD")) in the U.S. Excluding foreign exchange rates impact, revenue slightly increased in our key business areas of Gastroenterology ("GI"), Rare Diseases, Plasma-Derived Therapies ("PDT"), and Oncology, while there was a decline in Vaccines. Revenue outside of our six key business areas was JPY 51.2 billion (JPY -13.7 billion and -21.1% AER, -18.0% CER).

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Three-month

Period Ended June 30, 2025 (Consolidated)

***Revenue by Geographic Region***

The following shows revenue by geographic region:

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** |
| | **FY2024 Q1** | **FY2025 Q1** | AER | AER | CER |
| Revenue: | **FY2024 Q1** | **FY2025 Q1** | JPY Change | % Change | % Change |
| &nbsp;&nbsp;&nbsp;&nbsp;Japan | 102.9 | 108.0 | 5.0 | 4.9% | 5.1% |
| &nbsp;&nbsp;&nbsp;&nbsp;United States | 636.7 | 546.7 | (90.0) | (14.1)% | (8.4)% |
| &nbsp;&nbsp;&nbsp;&nbsp;Europe and Canada | 269.8 | 262.3 | (7.5) | (2.8)% | 0.2% |
| &nbsp;&nbsp;&nbsp;&nbsp;Latin America  | 72.2 | 57.6 | (14.6) | (20.3)% | (11.3)% |
| &nbsp;&nbsp;&nbsp;&nbsp;China | 38.2 | 43.2 | 5.0 | 13.2% | 21.0% |
| &nbsp;&nbsp;&nbsp;&nbsp;Asia (excluding Japan & China) | 25.7 | 23.0 | (2.7) | (10.5)% | (5.0)% |
| &nbsp;&nbsp;&nbsp;&nbsp;Russia/CIS | 23.7 | 28.9 | 5.2 | 21.9% | 19.2% |
| &nbsp;&nbsp;&nbsp;&nbsp;Other<sup>\*1</sup> | 38.7 | 37.0 | (1.8) | (4.6)% | (1.5)% |
| &nbsp;&nbsp;&nbsp;&nbsp;Total | 1208.0 | 1106.7 | (101.3) | (8.4)% | (3.7)% |

---

\*1 Other includes the Middle East, Oceania and Africa.

***Revenue by Business Area***

The following shows revenue by business area:

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** |
| | **FY2024 Q1** | **FY2025 Q1** | AER | AER | CER |
| Revenue: | **FY2024 Q1** | **FY2025 Q1** | JPY Change | % Change | % Change |
| &nbsp;&nbsp;&nbsp;&nbsp;GI | 348.5 | 339.3 | (9.2) | (2.6)% | 2.6% |
| &nbsp;&nbsp;&nbsp;&nbsp;Rare Diseases | 199.5 | 196.4 | (3.1) | (1.6)% | 3.0% |
| &nbsp;&nbsp;&nbsp;&nbsp;PDT | 271.4 | 260.9 | (10.6) | (3.9)% | 1.7% |
| &nbsp;&nbsp;&nbsp;&nbsp;Oncology | 142.1 | 138.8 | (3.3) | (2.3)% | 1.8% |
| &nbsp;&nbsp;&nbsp;&nbsp;Vaccines | 12.5 | 11.5 | (1.1) | (8.4)% | (6.2)% |
| &nbsp;&nbsp;&nbsp;&nbsp;Neuroscience | 169.1 | 108.6 | (60.4) | (35.7)% | (32.6)% |
| &nbsp;&nbsp;&nbsp;&nbsp;Other | 64.9 | 51.2 | (13.7) | (21.1)% | (18.0)% |
| &nbsp;&nbsp;&nbsp;&nbsp;Total | 1208.0 | 1106.7 | (101.3) | (8.4)% | (3.7)% |

---

Year-on-year change in revenue for this three-month period in each of our business areas was primarily attributable to the following products:

***GI*** 

In GI, revenue was JPY 339.3 billion (JPY -9.2 billion and -2.6% AER, +2.6% CER).

Sales of DEXILANT (for acid reflux disease) were JPY 8.3 billion (JPY -3.5 billion and -29.7% AER, -22.4% CER). The decrease was primarily due to the impact of multiple generic entrants in Canada, accompanied by unfavorable foreign exchange rates.

Sales of RESOLOR/MOTEGRITY (for chronic idiopathic constipation) were JPY 2.2 billion (JPY -3.3 billion and -60.5% AER, -58.2% CER). The decrease was primarily due to the impact of multiple generic entrants in the U.S. beginning in January 2025.

Sales of GATTEX/REVESTIVE (for short bowel syndrome) were JPY 34.8 billion (JPY -2.0 billion and -5.5% AER, +0.0% CER). The decrease was primarily due to unfavorable foreign exchange rates.

Sales of ENTYVIO (for ulcerative colitis ("UC") and Crohn's disease ("CD")) were JPY 232.5 billion (JPY -1.9 billion and -0.8% AER, +4.9% CER). Sales in the U.S. were JPY 156.3 billion (JPY -6.6 billion and -4.1% AER). The decrease was due to unfavorable foreign exchange rates, partially offset by maintaining demand in the first line biologic inflammatory bowel disease ("IBD") population, reflecting continued patient gains from the subcutaneous formulation. Sales in Europe and Canada were JPY 56.7 billion (JPY +1.9 billion and +3.5% AER). The increase was primarily due to continued patient gains through an increased use of the subcutaneous formulation, partially offset by unfavorable foreign exchange rates.

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Three-month

Period Ended June 30, 2025 (Consolidated)

Sales of TAKECAB/VOCINTI (for acid-related diseases) were JPY 35.0 billion (JPY +1.9 billion and +5.7% AER, +7.8% CER). The increase was due to strong demand in Japan, partially offset by unfavorable foreign exchange rates.

***Rare Diseases***

In Rare Diseases, revenue was JPY 196.4 billion (JPY -3.1 billion and -1.6% AER, +3.0% CER).

Sales of ADVATE (for hemophilia A) were JPY 28.0 billion (JPY -3.9 billion and -12.2% AER, -7.6% CER). The decrease was primarily due to competitive pressure in the U.S., accompanied by unfavorable foreign exchange rates.

Sales of ADYNOVATE/ADYNOVI (for hemophilia A) were JPY 14.1 billion (JPY -3.6 billion and -20.3% AER, -16.7% CER). The decrease was primarily due to competitive pressure in the U.S., accompanied by unfavorable foreign exchange rates.

Sales of REPLAGAL (for Fabry disease) were JPY 20.2 billion (JPY -1.2 billion and -5.5% AER, -2.2% CER). The decrease was primarily due to unfavorable foreign exchange rates.

Sales of TAKHZYRO (for hereditary angioedema) were JPY 55.1 billion (JPY -0.9 billion and -1.7% AER, +3.7% CER). The decrease was primarily due to unfavorable foreign exchange rates. Excluding foreign exchange rates impact, sales increased due to higher demand in Europe and Canada, and Growth and Emerging Markets, supported by strong patient persistency and prophylactic market growth.

Sales of LIVTENCITY (for post-transplant cytomegalovirus ("CMV") infection/disease) were JPY 10.5 billion (JPY +2.9 billion and +37.6% AER, +45.1% CER). The increase was primarily attributable to continued performance in the U.S. market reflecting strong market penetration, complemented by continued geographical expansion in Europe and the Growth and Emerging Markets.

Sales of VPRIV (for Gaucher disease) were JPY 15.3 billion (JPY +1.6 billion and +11.7% AER, +16.2% CER). The increase was due to a sales growth in Growth and Emerging Markets, partially offset by unfavorable foreign exchange rates.

***PDT***

In PDT, revenue was JPY 260.9 billion (JPY -10.6 billion and -3.9% AER, +1.7% CER).

Aggregate sales of immunoglobulin products were JPY 194.0 billion (JPY -7.4 billion and -3.7% AER, +2.0% CER). Excluding foreign exchange rates impact, the sales increased due to a sales growth of subcutaneous immunoglobulin therapies (CUVITRU and HYQVIA). Sales of GAMMAGARD LIQUID/KIOVIG (for the treatment of primary immunodeficiency ("PID") and multifocal motor neuropathy ("MMN")), intravenous therapies, decreased primarily due to unfavorable foreign exchange rates.

Sales of FEIBA (for hemophilia A and B) were JPY 9.7 billion (JPY -4.3 billion and -30.5% AER, -27.1% CER). The decrease was due to a sales decline in Growth and Emerging Markets and Europe, accompanied by unfavorable foreign exchange rates.

Aggregate sales of albumin products including HUMAN ALBUMIN and FLEXBUMIN (both primarily used for hypovolemia and hypoalbuminemia) were JPY 32.2 billion (JPY +2.8 billion and +9.5% AER, +16.2% CER). The increase was primarily due to a sales increase in China, partially offset by unfavorable foreign exchange rates.

***Oncology***

In Oncology, revenue was JPY 138.8 billion (JPY -3.3 billion and -2.3% AER, +1.8% CER).

Sales of NINLARO (for multiple myeloma) were JPY 20.9 billion (JPY -3.0 billion and -12.6% AER, -8.3% CER). The decrease was primarily due to intensified competition and decreased demand mainly in the U.S., accompanied by unfavorable foreign exchange rates, and partially offset by a sales increase in Growth and Emerging Markets.

Sales of LEUPLIN/ENANTONE (for endometriosis, uterine fibroids, premenopausal breast cancer, prostate cancer, and other certain indications) were JPY 27.3 billion (JPY -2.1 billion and -7.1% AER, -4.7% CER). The decrease was primarily due to a sales decrease in the U.S., accompanied by unfavorable foreign exchange rates.

Sales of ALUNBRIG (for non-small cell lung cancer) were JPY 8.2 billion (JPY -1.2 billion and -13.0% AER, -8.5% CER). The decrease was primarily due to intensified competition, and unfavorable foreign exchange rates.

Sales of ADCETRIS (for malignant lymphomas) were JPY 37.2 billion (JPY +2.7 billion and +7.9% AER, +13.2% CER). The increase was led by strong demand in the Growth and Emerging Markets, partially offset by unfavorable foreign exchange rates.

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Three-month

Period Ended June 30, 2025 (Consolidated)

***Vaccines***

In Vaccines, revenue was JPY 11.5 billion (JPY -1.1 billion and -8.4% AER, -6.2% CER).

Sales of QDENGA (for prevention of dengue) were JPY 8.8 billion (JPY -0.7 billion and -7.7% AER, -4.8% CER). The decrease was due to shipment timing in Growth and Emerging Markets, accompanied by unfavorable foreign exchange rates.

***Neuroscience***

In Neuroscience, revenue was JPY 108.6 billion (JPY -60.4 billion and -35.7% AER, -32.6% CER).

Sales of VYVANSE/ELVANSE (for ADHD) were JPY 57.9 billion (JPY -56.8 billion and -49.5% AER, -46.9% CER). The decrease was due to the continued impact of multiple generic entrants in the U.S. and certain other countries.

Sales of TRINTELLIX (for major depressive disorder ("MDD")) were JPY 28.1 billion (JPY -2.9 billion, and -9.5% AER, -4.0% CER). The decrease was primarily due to unfavorable foreign exchange rates.

***Cost of Sales***

Cost of Sales was JPY 384.7 billion (JPY -2.3 billion and -0.6% AER, +4.3% CER). The decrease was primarily due to the appreciation of the Japanese yen, partially offset by a change in product mix.

***Selling, General and Administrative (SG&A) Expenses*** 

SG&A Expenses were JPY 255.9 billion (JPY -14.1 billion and -5.2% AER, -0.0% CER). The decrease was mainly due to the appreciation of the Japanese yen.

***Research and Development (R&D) Expenses***

R&D Expenses were JPY 143.9 billion (JPY -24.6 billion and -14.6% AER, -9.7% CER). The decrease was mainly due to lower expenses attributable to termination of development programs and the appreciation of the Japanese yen, partially offset by higher expense on late-stage pipelines in the three-month period ended June 30, 2025.

***Amortization and Impairment Losses on Intangible Assets Associated with Products***

Amortization and Impairment Losses on Intangible Assets Associated with Products were JPY 131.6 billion (JPY -31.2 billion and -19.2% AER, -14.3% CER). Amortization Expenses decreased (JPY -9.3 billion) mainly due to the appreciation of the Japanese yen. Impairment Losses decreased (JPY -21.9 billion) primarily due to an impairment charge for soticlestat (TAK-935) recorded during the three-month period ended June 30, 2024.

***Other Operating Income***

Other Operating Income was JPY 22.0 billion (JPY +11.2 billion and +102.7% AER, +102.1% CER). The increase was mainly due to higher gains from Divestment of Business during the three-month period ended June 30, 2025. Gains of JPY 17.9 billion were recognized on the completion of the sales of non-core products and MEPACT mainly in Europe and the Middle East & North Africa regions during the three-month period ended June 30, 2025, while a gain of JPY 6.1 billion was recognized on the completion of the transfer of the manufacturing operation of TACHOSIL during the three-month period ended June 30, 2024.

***Other Operating Expenses***

Other Operating Expenses were JPY 28.1 billion (JPY -36.2 billion and -56.3% AER, -53.6% CER). The decrease was primarily due to a reduction in restructuring expenses (JPY -31.0 billion), mainly attributable to lower restructuring expenses on the enterprise-wide efficiency program compared to the three-month period ended June 30, 2024.

***Operating Profit***

As a result of the above factors, Operating Profit was JPY 184.6 billion (JPY +18.2 billion and +11.0% AER, +14.0% CER).

***Net Finance Expenses***

Net Finance Expenses were JPY 33.4 billion (JPY +4.4 billion and +15.1% AER, +15.5% CER). The increase was mainly due to lower gains from the fair value measurement of debt instruments compared to the three-month period ended June 30, 2024.

***Share of Loss of Investments Accounted for Using the Equity Method***

Share of Loss of Investments Accounted for Using the Equity Method was JPY 0.5 billion (JPY -0.2 billion and -24.7% AER, -69.6% CER).

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Three-month

Period Ended June 30, 2025 (Consolidated)

***Income Tax Expenses***

Income Tax Expenses were JPY 26.4 billion (JPY -15.0 billion and -36.2% AER, -32.9% CER). The decrease was primarily due to the effect of a higher valuation allowance on deferred tax assets recognized during the three-month period ended June 30, 2024 partially offset by an increase in tax expenses due to lower level of tax credits recognized during the three-month period ended June 30, 2025.

***Net Profit for the Period***

As a result of the above factors, Net Profit for the Period was JPY 124.3 billion (JPY +29.0 billion and +30.4% AER, +34.5% CER) and Net Profit for the Period attributable to owners of the Company was JPY 124.2 billion (JPY +29.0 billion and +30.4% AER, +34.5% CER).

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Three-month

Period Ended June 30, 2025 (Consolidated)

**(ii) Results of Core Financial Measures (April 1 to June 30, 2025)**

***Definition and Explanation of Core Financial Measures and Constant Exchange Rate Change***

In addition to the financial statements in accordance with IFRS, Takeda uses the concept of Core Financial Measures for measuring financial performance. These measures are not defined by International Financial Reporting Standards (IFRS). See "Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations" in the Financial Appendix for additional information.

***Results of Core Operations***

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** |
| | **FY2024 Q1** | **FY2025 Q1** | AER | AER | CER |
| | **FY2024 Q1** | **FY2025 Q1** | JPY Change | % Change | % Change |
| Core revenue | 1208.0 | 1106.7 | (101.3) | (8.4)% | (3.7)% |
| Core operating profit | 382.3 | 321.8 | (60.4) | (15.8)% | (11.9)% |
| Core net profit for the period | 276.9 | 237.1 | (39.8) | (14.4)% | (10.3)% |
| Core net profit for the period attributable to owners of the Company | 276.8 | 237.0 | (39.8) | (14.4)% | (10.3)% |
| Core EPS (yen) | 176 | 151 | (25) | (14.1)% | (10.0)% |

---

***Core Revenue***

Core Revenue was JPY 1,106.7 billion (JPY -101.3 billion and -8.4% AER, -3.7% CER). The decrease was primarily attributable to unfavorable foreign exchange rates and a decrease in revenue in Neuroscience. The decrease in Neuroscience was largely attributable to the continued impact from generic erosion of VYVANSE in the U.S. Takeda's Growth and Launch Products\* totaled JPY 558.1 billion (JPY -3.6 billion and -0.6% AER, +5.0% CER).

\*&nbsp;&nbsp;&nbsp;&nbsp;Takeda's Growth and Launch Products

&nbsp;&nbsp;&nbsp;&nbsp;GI:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ENTYVIO, EOHILIA

&nbsp;&nbsp;&nbsp;&nbsp;Rare Diseases:&nbsp;&nbsp;&nbsp;&nbsp;TAKHZYRO, LIVTENCITY, ADZYNMA

&nbsp;&nbsp;&nbsp;&nbsp;PDT: &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Immunoglobulin products including GAMMAGARD LIQUID/KIOVIG, HYQVIA, and CUVITRU, &nbsp;&nbsp;&nbsp;&nbsp;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Albumin products including HUMAN ALBUMIN and FLEXBUMIN

&nbsp;&nbsp;&nbsp;&nbsp;Oncology:&nbsp;&nbsp;&nbsp;&nbsp; ALUNBRIG, FRUZAQLA

&nbsp;&nbsp;&nbsp;&nbsp;Vaccines:&nbsp;&nbsp;&nbsp;&nbsp; QDENGA

***Core Operating Profit***

Core Operating Profit was JPY 321.8 billion (JPY -60.4 billion and -15.8% AER, -11.9% CER). The components of Core Operating Profit are as below:

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** |
| | **FY2024 Q1** | **FY2025 Q1** | AER | AER | CER |
| | **FY2024 Q1** | **FY2025 Q1** | JPY Change | % Change | % Change |
| Core revenue | 1208.0 | 1106.7 | (101.3) | (8.4)% | (3.7)% |
| Core cost of sales | (387.1) | (384.9) | 2.2 | (0.6)% | 4.4% |
| Core selling, general and administrative (SG&A) expenses | (270.2) | (256.0) | 14.1 | (5.2)% | (0.0)% |
| Core research and development (R&D) expenses | (168.5) | (143.9) | 24.6 | (14.6)% | (9.7)% |
| Core operating profit | 382.3 | 321.8 | (60.4) | (15.8)% | (11.9)% |

---

During the periods presented, these items fluctuated as follows:

***Core Cost of Sales***

Core Cost of Sales was JPY 384.9 billion (JPY -2.2 billion and -0.6% AER, +4.4% CER). The decrease was primarily due to the appreciation of the Japanese yen, partially offset by a change in product mix.

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Three-month

Period Ended June 30, 2025 (Consolidated)

***Core Selling, General and Administrative (SG&A) Expenses***

Core SG&A expenses were JPY 256.0 billion (JPY -14.1 billion and -5.2% AER, -0.0% CER). The decrease was mainly due to the appreciation of the Japanese yen.

***Core Research and Development (R&D) Expenses***

Core R&D expenses were JPY 143.9 billion (JPY -24.6 billion and -14.6% AER, -9.7% CER). The decrease was mainly due to lower expenses attributable to termination of development programs and the appreciation of the Japanese yen, partially offset by higher expense on late-stage pipelines in the three-month period ended June 30, 2025.

***Core Net Profit for the Period***

Core Net Profit for the Period was JPY 237.1 billion (JPY -39.8 billion and -14.4% AER, -10.3% CER) and Core Net Profit attributable to owners of the Company was JPY 237.0 billion (JPY -39.8 billion and -14.4% AER, -10.3% CER) and are calculated from Core Operating Profit as below:

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** | **Billion JPY or percentage** |
| | **FY2024 Q1** | **FY2025 Q1** | AER | AER | CER |
| | **FY2024 Q1** | **FY2025 Q1** | JPY Change | % Change | % Change |
| Core operating profit | 382.3 | 321.8 | (60.4) | (15.8)% | (11.9)% |
| Core finance income and (expenses), net | (30.1) | (31.3) | (1.2) | 4.1% | 4.4% |
| Core share of profit (loss) of investments accounted for using the equity method | 0.4 | (0.1) | (0.5) | ― | (44.8)% |
| Core profit before tax | 352.6 | 290.4 | (62.2) | (17.6)% | (13.4)% |
| Core income tax expenses | (75.7) | (53.3) | 22.4 | (29.6)% | (24.8)% |
| Core net profit for the period | 276.9 | 237.1 | (39.8) | (14.4)% | (10.3)% |
| Core net profit for the period attributable to owners of the Company | 276.8 | 237.0 | (39.8) | (14.4)% | (10.3)% |

---

During the periods presented, these items fluctuated as follows:

***Core Net Finance Expenses***

Core Net Finance Expenses were JPY 31.3 billion (JPY +1.2 billion and +4.1% AER, +4.4% CER).

***Core Share of Profit (Loss) of Investments Accounted for Using the Equity Method***

For the three-month period ended June 30, 2025, Core Share of Loss of Investments Accounted for Using the Equity Method was JPY 0.1 billion (JPY -0.5 billion). For the three-month period ended June 30, 2024, Core Share of Profit of Investments Accounted for Using the Equity Method was JPY 0.4 billion.

***Core Profit Before Tax***

Core Profit Before Tax was JPY 290.4 billion (JPY -62.2 billion and -17.6% AER, -13.4% CER).

***Core Income Tax Expenses***

Core Income Tax Expenses were JPY 53.3 billion (JPY -22.4 billion and -29.6% AER, -24.8% CER). The decrease was primarily due to the effect of a higher valuation allowance on deferred tax assets recognized during the three-month period ended June 30, 2024 and lower pretax earnings partially offset by an increase in tax expenses due to lower level of tax credits recognized during the three-month period ended June 30, 2025.

***Core EPS***

Core EPS was JPY 151 (JPY -25 and -14.1% AER, -10.0% CER).

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Three-month

Period Ended June 30, 2025 (Consolidated)

**(2) Consolidated Financial Position**

**(i) Assets, Liabilities and Equity**

---

| | | | |
|:---|:---|:---|:---|
| | **Billion JPY** | **Billion JPY** | **Billion JPY** |
| | **As of** | **As of** | **Change** |
| | **March 31, 2025** | **June 30, 2025** | **Change** |
| Total Assets | 14248.3 | 14004.5 | (243.8) |
| Total Liabilities | 7312.4 | 7138.4 | (174.0) |
| Total Equity | 6936.0 | 6866.2 | (69.8) |

---

***Assets***

Total Assets as of June 30, 2025 were JPY 14,004.5 billion (JPY -243.8 billion). Intangible Assets decreased (JPY -209.0 billion) mainly due to amortization and the effect of foreign currency translation.

***Liabilities***

Total Liabilities as of June 30, 2025 were JPY 7,138.4 billion (JPY -174.0 billion). Other Current Liabilities decreased (JPY -79.3 billion) mainly due to the payment of accrued bonus, as well as a reduction in accrued expenses primarily driven by the effect of foreign currency translation. In addition, Trade and Other Payables decreased (JPY -54.2 billion) mainly due to the payment of accounts payables in the U.S. and Japan. Total Bonds and Loans were JPY 4,505.9 billion\*.

<sup>\*</sup> The carrying amount of Bonds was JPY 4,193.8 billion and Loans was JPY 312.1 billion as of June 30, 2025. Breakdown of Bonds and Loans' carrying amount is as follows.

<u>Bonds</u>:

---

| | | | |
|:---|:---|:---|:---|
| **Name of Bond**<br> **(Face Value if Denominated in Foreign Currency)** | **Issuance** | **Maturity** | **Carrying Amount**<br>**(Billion JPY)** |
| Unsecured US Dollar Denominated Senior Notes (USD 500 million) | June 2015 | June 2045 | 73.5 |
| Unsecured US Dollar Denominated Senior Notes (USD 1,500 million) | September 2016 | September 2026 | 212.5 |
| Unsecured Euro Denominated Senior Notes<br>(EUR 3,000 million) | November 2018 | November 2026 ~<br>November 2030 | 505.2 |
| Unsecured US Dollar Denominated Senior Notes (USD 1,750 million) | November 2018 | November 2028 | 251.2 |
| Unsecured US Dollar Denominated Senior Notes (USD 7,000 million) | July 2020 | March 2030 ~<br>July 2060 | 1003.1 |
| Unsecured Euro Denominated Senior Notes<br>(EUR 3,600 million) | July 2020 | July 2027 ~<br>July 2040 | 605.3 |
| Unsecured JPY Denominated Senior Bonds | October 2021 | October 2031 | 249.6 |
| Hybrid Bonds (Subordinated Bonds) | June 2024 | June 2084 | 458.1 |
| Unsecured US Dollar Denominated Senior Notes (USD 3,000 million) | July 2024 | July 2034 ~<br>July 2064 | 427.7 |
| Unsecured JPY Denominated Senior Bonds | June 2025 | June 2030 ~<br>June 2035 | 183.6 |
| Commercial Paper | May 2025 ～<br>June 2025 | July 2025 | 224.0 |
| Total |  |  | 4193.8 |

---

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Three-month

Period Ended June 30, 2025 (Consolidated)

<u>Loans</u>:

---

| | | | |
|:---|:---|:---|:---|
| **Name of Loan**<br> **(Face Value if Denominated in Foreign Currency)** | **Execution** | **Maturity** | **Carrying Amount**<br>**(Billion JPY)** |
| Bilateral Loans | March 2016 ~ <br>April 2024 | March 2026 ~<br>April 2031 | 200.0 |
| Bilateral Loans (USD 500 million) | June 2025 | July 2025 | 72.1 |
| Syndicated Hybrid Loans (Subordinated Loans) | October 2024 | October 2084 | 40.0 |
| Other |  |  | 0.1 |
| Total |  |  | 312.1 |

---

On April 25, 2025, Takeda repaid JPY 10.0 billion in Bilateral Loans falling due. On June 12, 2025, Takeda issued JPY 184.0 billion in unsecured JPY denominated senior bonds ("JPY Bonds") with maturity dates ranging from June 12, 2030, to June 12, 2035. The proceeds of the JPY Bonds will be used to redeem commercial paper. Following this, on June 23, 2025, Takeda redeemed USD 800 million of unsecured U.S. dollar-denominated senior notes on their maturity date. Takeda has also rolled over USD 500 million Bilateral Loan, which was originally drawn down on March 31, 2025, on a monthly basis until July 3, 2025.

\*Amounts presented in the above explanation for Bonds and Loans are based on the principal amount.

***Equity***

Total Equity as of June 30, 2025 was JPY 6,866.2 billion (JPY -69.8 billion). This decrease was primarily due to the increase in Treasury Shares (JPY -49.3 billion), mainly attributed to an acquisition of Takeda's own shares.

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Three-month

Period Ended June 30, 2025 (Consolidated)

**(ii) Consolidated Cash Flows**

---

| | | | |
|:---|:---|:---|:---|
| | **Billion JPY** | **Billion JPY** | **Billion JPY** |
| | **FY2024 Q1** | **FY2025 Q1** | **Change** |
| Net cash from operating activities | 170.3 | 215.4 | 45.1 |
| Net cash used in investing activities | (156.7) | (33.2) | 123.5 |
| Net cash from (used in) financing activities | 316.4 | (214.9) | (531.3) |
| Net increase (decrease) in cash and cash equivalents | 330.0 | (32.7) | (362.7) |
| Cash and cash equivalents at the beginning of the year | 457.8 | 385.1 | (72.7) |
| Effects of exchange rate changes on cash and cash equivalents | 17.2 | (2.4) | (19.7) |
| Cash and cash equivalents reclassified to assets held for sale | (0.7) |  | 0.7 |
| Cash and cash equivalents at the end of the period<br>(Condensed interim consolidated statements of financial position) | 804.3 | 350.0 | (454.3) |

---

***Net Cash from Operating Activities***

Net Cash from Operating Activities was JPY 215.4 billion (JPY +45.1 billion). The increase was mainly due to favorable impacts from Changes in Assets and Liabilities primarily driven by changes in Trade and Other Receivables, Provisions and Other Financial Liabilities. The increase was partially offset by unfavorable impacts resulting from Net Profit for the Period adjusted for non-cash items and other adjustments.

***Net Cash used in Investing Activities***

Net Cash used in Investing Activities was JPY 33.2 billion (JPY -123.5 billion). The decrease was mainly due to a decrease in cash outflow used in Acquisition of Intangible Assets, further driven by an increase in Proceeds from Sales of Business, Net of Cash and Cash Equivalents Divested.

***Net Cash used in Financing Activiti*es** 

Net Cash used in Financing Activities was JPY 214.9 billion (JPY +531.3 billion). The increase was mainly driven by lower net cash inflows from the issuance and repayments of bonds and long-term loans as well as increased treasury share acquisitions.

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Three-month

Period Ended June 30, 2025 (Consolidated)

**(3) Outlook for the Fiscal Year Ending March 31, 2026**

The full year consolidated forecast for the fiscal year ending March 31, 2026 (FY2025) has not been revised from the forecast announced at the FY2024 financial results announcement on May 8, 2025.

**Consolidated Forecast for the Fiscal Year Ending March 31, 2026 (FY2025)**

---

| | | | | |
|:---|:---|:---|:---|:---|
| | | | Billion JPY or percentage | Billion JPY or percentage |
| |<br>**FY2024**<br>**Actual Results** |<br>**FY2025**<br>**Forecast** | **JPY Change** | **% Change** |
| Revenue | 4581.6 | 4530.0 | (51.6) | (1.1)% |
| Operating profit | 342.6 | 475.0 | 132.4 | 38.7% |
| Profit before tax | 175.1 | 307.0 | 131.9 | 75.3% |
| Net profit for the year<br>(attributable to owners of the Company) | 107.9 | 228.0 | 120.1 | 111.3% |
| EPS (JPY) | 68.36 | 144.81 | 76.45 | 111.8% |
| Core revenue<sup>\*1</sup> | 4579.8 | 4530.0 | (49.8) | (1.1)% |
| Core operating profit<sup>\*1</sup> | 1162.6 | 1140.0 | (22.6) | (1.9)% |
| Core EPS (JPY)<sup>\*1</sup> | 491 | 485 | (6) | (1.2)% |

---

\*1 Please refer to "Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations" in the Financial Appendix for the definition.

**Major assumptions used in preparing the FY2025 Forecast**

---

| | | |
|:---|:---|:---|
| |<br>**FY2024<br>Actual Results** | Billion JPY or percentage<br>**FY2025**<br>**Forecast** |
| FX rates |  |  |
| USD/JPY<br>EUR/JPY<br>RUB/JPY <br>CNY/JPY<br>BRL/JPY | 152 JPY<br>163 JPY<br>1.6 JPY<br>21.1 JPY<br>27.4 JPY | 150 JPY<br>160 JPY<br>1.7 JPY<br>20.5 JPY<br>25.9 JPY |
| Cost of sales | (1580.2) | (1540.0) |
| SG&A expenses | (1104.8) | (1100.0) |
| R&D expenses | (730.2) | (750.0) |
| Amortization of intangible assets associated with products | (548.2) | (500.0) |
| Impairment of intangible assets associated with products<sup>\*2</sup> | (95.0) | (50.0) |
| Other operating income | 26.2 | 10.0 |
| Other operating expenses<sup>\*3</sup> | (206.7) | (125.0) |
| Other core operating profit adjustments | (2.0) |  |
| Finance income and (expenses), net | (163.5) | (167.0) |
| Adjusted free cash flow<sup>\*1</sup> | 769.0 | 750.0 to 850.0 |
| Capital expenditures (cash flow base) | (347.8) | (270.0) to (320.0) |
| Depreciation and amortization (excluding intangible assets associated with products) | (213.2) | (216.0) |
| Cash tax rate on adjusted EBITDA (excluding divestitures)<sup>\*1</sup> | Approx.10% | Mid teen% |

---

\*2 Includes in-process R&D.

\*3 Includes restructuring expense primarily related to the enterprise-wide efficiency program of JPY 128.1 billion in FY2024 actual results and JPY 48.0 billion in FY2025 forecast.

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Three-month

Period Ended June 30, 2025 (Consolidated)

**Management Guidance for the Fiscal Year Ending March 31, 2026 (FY2025)** 

Takeda uses change in Core Revenue, Core Operating Profit and Core EPS at Constant Exchange Rate (CER) basis as its Management Guidance. The full year management guidance for the fiscal year ending March 31, 2026 (FY2025) has not been revised from the management guidance announced on May 8, 2025.

---

| | |
|:---|:---|
| | **FY2025 Management Guidance**<br>**CER % Change**<sup>\*1</sup> |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Core revenue | Broadly Flat |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Core operating profit | Broadly Flat |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Core EPS | Broadly Flat |

---

**Other assumptions used in preparing the FY2025 Forecast and the Management Guidance**

• The FY2025 forecast and the management guidance do not reflect the potential impact of tariffs being introduced on pharmaceutical products by the U.S. administration, nor the potential impact of tariffs introduced by other countries in response to U.S. tariffs.

• The FY2025 forecast and the management guidance assume global VYVANSE sales of JPY 241.0 billion, a year-on-year decline of JPY 109.6 billion (30% decline at CER).

**Forward looking statements**

All forecasts in this document are based on information currently available to management, and do not represent a promise or guarantee to achieve these forecasts. Various uncertain factors could cause actual results to differ, such as changes in the business environment and fluctuations in foreign exchange rates. Should any significant event occur which requires the forecast to be revised, the Company will disclose it in a timely manner.

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Three-month

Period Ended June 30, 2025 (Consolidated)

**2. Condensed Interim Consolidated Financial Statements [IFRS] and Major Notes**

**(1) Condensed Interim Consolidated Statements of Profit or Loss**

---

| | | |
|:---|:---|:---|
| | **JPY (millions, except per share data)** | **JPY (millions, except per share data)** |
| | **Three-month Period Ended June 30,** | **Three-month Period Ended June 30,** |
| | **2024** | **2025** |
| Revenue | 1207990 | 1106685 |
| Cost of sales | (386954) | (384675) |
| Selling, general and administrative expenses | (270030) | (255885) |
| Research and development expenses | (168463) | (143891) |
| Amortization and impairment losses on intangible assets associated with products | (162831) | (131638) |
| Other operating income | 10868 | 22030 |
| Other operating expenses | (64252) | (28061) |
| Operating profit | 166329 | 184566 |
| Finance income | 30677 | 73758 |
| Finance expenses | (59691) | (107158) |
| Share of loss of investments accounted for using the equity method | (712) | (536) |
| Profit before tax | 136604 | 150630 |
| Income tax expenses | (41304) | (26351) |
| Net profit for the period | 95299 | 124279 |
| Attributable to: |  |  |
| &nbsp;&nbsp;Owners of the Company | 95248 | 124243 |
| &nbsp;&nbsp;Non-controlling interests | 51 | 36 |
| Net profit for the period | 95299 | 124279 |
| Earnings per share (JPY) |  |  |
| &nbsp;&nbsp;Basic earnings per share | 60.71 | 79.40 |
| &nbsp;&nbsp;Diluted earnings per share | 59.94 | 78.23 |

---

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Three-month

Period Ended June 30, 2025 (Consolidated)

**(2) Condensed Interim Consolidated Statements of Comprehensive Income**

---

| | | |
|:---|:---|:---|
| | **JPY (millions)** | **JPY (millions)** |
| | **Three-month Period Ended June 30,** | **Three-month Period Ended June 30,** |
| | **2024** | **2025** |
| Net profit for the period | 95299 | 124279 |
| Other comprehensive income (loss) |  |  |
| Items that will not be reclassified to profit or loss: |  |  |
| &nbsp;&nbsp;&nbsp;Changes in fair value of financial assets measured at fair value through other comprehensive income | (5077) | 9437 |
| &nbsp;&nbsp;&nbsp;Remeasurement of defined benefit pension plans | 1916 | (397) |
|  | (3160) | 9040 |
| Items that may be reclassified subsequently to profit or loss: |  |  |
| &nbsp;&nbsp;&nbsp;Exchange differences on translation of foreign operations | 563483 | (19647) |
| &nbsp;&nbsp;&nbsp;Cash flow hedges | (3271) | 3655 |
| &nbsp;&nbsp;&nbsp;Hedging cost | 6908 | 1892 |
| &nbsp;&nbsp;&nbsp;Share of other comprehensive income (loss) of investments accounted for using the equity method | 864 | (119) |
|  | 567983 | (14218) |
| Other comprehensive income (loss) for the period, net of tax | 564823 | (5178) |
| Total comprehensive income for the period | 660122 | 119101 |
| Attributable to: |  |  |
| &nbsp;&nbsp;&nbsp;Owners of the Company | 660048 | 119076 |
| &nbsp;&nbsp;&nbsp;Non-controlling interests | 74 | 25 |
| Total comprehensive income for the period | 660122 | 119101 |

---

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Three-month

Period Ended June 30, 2025 (Consolidated)

**(3) Condensed Interim Consolidated Statements of Financial Position**

---

| | | |
|:---|:---|:---|
| | **JPY (millions)** | **JPY (millions)** |
| | **As of March 31, 2025** | **As of June 30, 2025** |
| **<u>ASSETS</u>** | | |
| Non-current assets: |  |  |
| &nbsp;&nbsp;&nbsp;Property, plant and equipment | 1968209 | 1956269 |
| &nbsp;&nbsp;&nbsp;Goodwill | 5324430 | 5295871 |
| &nbsp;&nbsp;&nbsp;Intangible assets | 3631560 | 3422542 |
| &nbsp;&nbsp;&nbsp;Investments accounted for using the equity method | 10802 | 9947 |
| &nbsp;&nbsp;&nbsp;Other financial assets | 351124 | 337173 |
| &nbsp;&nbsp;&nbsp;Other non-current assets | 70282 | 68555 |
| &nbsp;&nbsp;&nbsp;Deferred tax assets | 370745 | 401058 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total non-current assets | 11727152 | 11491416 |
| Current assets: |  |  |
| &nbsp;&nbsp;&nbsp;Inventories | 1217349 | 1240676 |
| &nbsp;&nbsp;&nbsp;Trade and other receivables | 709465 | 665632 |
| &nbsp;&nbsp;&nbsp;Other financial assets | 20476 | 69167 |
| &nbsp;&nbsp;&nbsp;Income taxes receivable | 15789 | 13899 |
| &nbsp;&nbsp;&nbsp;Other current assets | 159603 | 173740 |
| &nbsp;&nbsp;&nbsp;Cash and cash equivalents | 385113 | 350008 |
| &nbsp;&nbsp;&nbsp;Assets held for sale | 13397 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total current assets | 2521192 | 2513122 |
| Total assets | 14248344 | 14004537 |

---

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Three-month

Period Ended June 30, 2025 (Consolidated)

---

| | | |
|:---|:---|:---|
| | **JPY (millions)** | **JPY (millions)** |
| | **As of March 31, 2025** | **As of June 30, 2025** |
| **<u>LIABILITIES AND EQUITY</u>** | | |
| LIABILITIES |  |  |
| Non-current liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;Bonds and loans | 3966326 | 4134799 |
| &nbsp;&nbsp;&nbsp;Other financial liabilities | 550900 | 535165 |
| &nbsp;&nbsp;&nbsp;Net defined benefit liabilities | 135429 | 141512 |
| &nbsp;&nbsp;&nbsp;Income taxes payable | 317 | 396 |
| &nbsp;&nbsp;&nbsp;Provisions | 35177 | 34265 |
| &nbsp;&nbsp;&nbsp;Other non-current liabilities | 82542 | 89122 |
| &nbsp;&nbsp;&nbsp;Deferred tax liabilities | 35153 | 33514 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total non-current liabilities | 4805844 | 4968772 |
| Current liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;Bonds and loans | 548939 | 371143 |
| &nbsp;&nbsp;&nbsp;Trade and other payables | 475541 | 421308 |
| &nbsp;&nbsp;&nbsp;Other financial liabilities | 219120 | 205120 |
| &nbsp;&nbsp;&nbsp;Income taxes payable | 133497 | 150965 |
| &nbsp;&nbsp;&nbsp;Provisions | 533140 | 504069 |
| &nbsp;&nbsp;&nbsp;Other current liabilities | 596283 | 516981 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total current liabilities | 2506521 | 2169586 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total liabilities | 7312365 | 7138358 |
| EQUITY |  |  |
| &nbsp;&nbsp;&nbsp;Share capital | 1694685 | 1694711 |
| &nbsp;&nbsp;&nbsp;Share premium | 1775713 | 1790509 |
| &nbsp;&nbsp;&nbsp;Treasury shares | (74815) | (124124) |
| &nbsp;&nbsp;&nbsp;Retained earnings | 1187586 | 1156692 |
| &nbsp;&nbsp;&nbsp;Other components of equity | 2351915 | 2347471 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Equity attributable to owners of the Company | 6935084 | 6865259 |
| &nbsp;&nbsp;&nbsp;Non-controlling interests | 895 | 921 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total equity | 6935979 | 6866179 |
| Total liabilities and equity | 14248344 | 14004537 |

---

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Three-month

Period Ended June 30, 2025 (Consolidated)

**(4) Condensed Interim Consolidated Statements of Changes in Equity**

Three-month period ended June 30, 2024 (From April 1 to June 30, 2024)

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| | **JPY (millions)** | **JPY (millions)** | **JPY (millions)** | **JPY (millions)** | **JPY (millions)** | **JPY (millions)** |
| | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** |
| | **Share<br>capital** | **Share<br>premium** | **Treasury<br>shares** | **Retained<br>earnings** | **Other components of equity** | **Other components of equity** |
| | **Share<br>capital** | **Share<br>premium** | **Treasury<br>shares** | **Retained<br>earnings** | **Exchange<br>differences<br>on translation<br>of foreign<br>operations** | **Changes in fair value of financial assets measured at fair value through other comprehensive income** |
| As of April 1, 2024 | 1676596 | 1747414 | (51259) | 1391203 | 2573407 | 15729 |
| Net profit for the period |  |  |  | 95248 |  |  |
| Other comprehensive income (loss) |  |  |  |  | 564327 | (5080) |
| Comprehensive income (loss) for the period |  |  |  | 95248 | 564327 | (5080) |
| Transactions with owners: |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition of treasury shares |  |  | (1913) |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Disposal of treasury shares |  | 0 | 0 |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Dividends |  |  |  | (147655) |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Transfers from other components of equity |  |  |  | (603) |  | 2520 |
| &nbsp;&nbsp;&nbsp;&nbsp;Share-based compensation |  | 14673 |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Exercise of share-based awards |  | (2274) | 2274 |  |  |  |
| Total transactions with owners |  | 12399 | 361 | (148258) |  | 2520 |
| As of June 30, 2024 | 1676596 | 1759813 | (50897) | 1338192 | 3137735 | 13169 |

---

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | | |
| | **Other components of equity** | **Other components of equity** | **Other components of equity** | **Other components of equity** | | | |
| | **Cash flow<br>hedges** | **Hedging<br>cost** | **Remeasurements of defined benefit pension plans** | **Total <br>other components of equity** |<br>**Total <br>equity attributable to owners of the Company** |<br>**Non-<br>controlling<br>interests** |<br>**Total<br>equity** |
| As of April 1, 2024 | (63896) | (15930) |  | 2509310 | 7273264 | 741 | 7274005 |
| Net profit for the period |  |  |  |  | 95248 | 51 | 95299 |
| Other comprehensive income (loss) | (3271) | 6908 | 1916 | 564800 | 564800 | 23 | 564823 |
| Comprehensive income (loss) for the period | (3271) | 6908 | 1916 | 564800 | 660048 | 74 | 660122 |
| Transactions with owners: |  |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition of treasury shares |  |  |  |  | (1913) |  | (1913) |
| &nbsp;&nbsp;&nbsp;&nbsp;Disposal of treasury shares |  |  |  |  | 0 |  | 0 |
| &nbsp;&nbsp;&nbsp;&nbsp;Dividends |  |  |  |  | (147655) |  | (147655) |
| &nbsp;&nbsp;&nbsp;&nbsp;Transfers from other components of equity |  |  | (1916) | 603 |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Share-based compensation |  |  |  |  | 14673 |  | 14673 |
| &nbsp;&nbsp;&nbsp;&nbsp;Exercise of share-based awards |  |  |  |  |  |  |  |
| Total transactions with owners |  |  | (1916) | 603 | (134895) |  | (134895) |
| As of June 30, 2024 | (67167) | (9022) |  | 3074714 | 7798417 | 815 | 7799232 |

---

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Three-month

Period Ended June 30, 2025 (Consolidated)

Three-month period ended June 30, 2025 (From April 1 to June 30, 2025)

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| | **JPY (millions)** | **JPY (millions)** | **JPY (millions)** | **JPY (millions)** | **JPY (millions)** | **JPY (millions)** |
| | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** |
| | **Share<br>capital** | **Share<br>premium** | **Treasury<br>shares** | **Retained<br>earnings** | **Other components of equity** | **Other components of equity** |
| | **Share<br>capital** | **Share<br>premium** | **Treasury<br>shares** | **Retained<br>earnings** | **Exchange<br>differences<br>on translation<br>of foreign<br>operations** | **Changes in fair value of financial assets measured at fair value through other comprehensive income** |
| As of April 1, 2025 | 1694685 | 1775713 | (74815) | 1187586 | 2419978 | 4757 |
| Net profit for the period |  |  |  | 124243 |  |  |
| Other comprehensive income (loss) |  |  |  |  | (19755) | 9437 |
| Comprehensive income (loss) for the period |  |  |  | 124243 | (19755) | 9437 |
| Transactions with owners: |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of new shares | 27 | 27 |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition of treasury shares |  | (20) | (51605) |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Dividends |  |  |  | (154413) |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Transfers from other components of equity |  |  |  | (724) |  | 327 |
| &nbsp;&nbsp;&nbsp;&nbsp;Share-based compensation |  | 17084 |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Exercise of share-based awards |  | (2296) | 2296 |  |  |  |
| Total transactions with owners | 27 | 14795 | (49309) | (155137) |  | 327 |
| As of June 30, 2025 | 1694711 | 1790509 | (124124) | 1156692 | 2400223 | 14521 |

---

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | **Equity attributable to owners of the Company** | | |
| | **Other components of equity** | **Other components of equity** | **Other components of equity** | **Other components of equity** | | | |
| | **Cash flow<br>hedges** | **Hedging<br>cost** | **Remeasurements of defined benefit pension plans** | **Total <br>other components of equity** |<br>**Total <br>equity attributable to owners of the Company** |<br>**Non-<br>controlling<br>interests** |<br>**Total<br>equity** |
| As of April 1, 2025 | (64852) | (7967) |  | 2351915 | 6935084 | 895 | 6935979 |
| Net profit for the period |  |  |  |  | 124243 | 36 | 124279 |
| Other comprehensive income (loss) | 3655 | 1892 | (397) | (5168) | (5168) | (11) | (5178) |
| Comprehensive income (loss) for the period | 3655 | 1892 | (397) | (5168) | 119076 | 25 | 119101 |
| Transactions with owners: |  |  |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Issuance of new shares |  |  |  |  | 53 |  | 53 |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition of treasury shares |  |  |  |  | (51625) |  | (51625) |
| &nbsp;&nbsp;&nbsp;&nbsp;Dividends |  |  |  |  | (154413) |  | (154413) |
| &nbsp;&nbsp;&nbsp;&nbsp;Transfers from other components of equity |  |  | 397 | 724 |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Share-based compensation |  |  |  |  | 17084 |  | 17084 |
| &nbsp;&nbsp;&nbsp;&nbsp;Exercise of share-based awards |  |  |  |  |  |  |  |
| Total transactions with owners |  |  | 397 | 724 | (188901) |  | (188901) |
| As of June 30, 2025 | (61197) | (6075) |  | 2347471 | 6865259 | 921 | 6866179 |

---

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Three-month

Period Ended June 30, 2025 (Consolidated)

**(5) Condensed Interim Consolidated Statements of Cash Flows**

---

| | | |
|:---|:---|:---|
| | **JPY (millions)** | **JPY (millions)** |
| | **Three-month Period Ended June 30,** | **Three-month Period Ended June 30,** |
| | **2024** | **2025** |
| Cash flows from operating activities: |  |  |
| &nbsp;&nbsp;&nbsp;Net profit for the period | 95299 | 124279 |
| &nbsp;&nbsp;&nbsp;Depreciation and amortization | 192220 | 181636 |
| &nbsp;&nbsp;&nbsp;Impairment losses | 26000 | 2357 |
| &nbsp;&nbsp;&nbsp;Equity-settled share-based compensation | 15386 | 16531 |
| &nbsp;&nbsp;&nbsp;Loss on sales and disposal of property, plant and equipment | 2088 | 584 |
| &nbsp;&nbsp;&nbsp;Gain on divestment of business and subsidiaries | (6229) | (17900) |
| &nbsp;&nbsp;&nbsp;Change in fair value of financial assets and liabilities associated with contingent consideration arrangements, net | (12) | 764 |
| &nbsp;&nbsp;&nbsp;Finance (income) and expenses, net | 29014 | 33400 |
| &nbsp;&nbsp;&nbsp;Share of loss of investments accounted for using the equity method | 712 | 536 |
| &nbsp;&nbsp;&nbsp;Income tax expenses | 41304 | 26351 |
| &nbsp;&nbsp;&nbsp;Changes in assets and liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Decrease (increase) in trade and other receivables | (47744) | 48083 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Increase in inventories | (10079) | (13069) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Decrease in trade and other payables | (37455) | (27780) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Increase (decrease) in provisions | 6120 | (23404) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Increase (decrease) in other financial liabilities | 8964 | (17531) |
| &nbsp;&nbsp;&nbsp;Other, net | (109785) | (86420) |
| &nbsp;&nbsp;&nbsp;&nbsp;Cash generated from operations | 205805 | 248418 |
| &nbsp;&nbsp;&nbsp;Income taxes paid | (37811) | (36653) |
| &nbsp;&nbsp;&nbsp;Tax refunds and interest on tax refunds received | 2310 | 3658 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net cash from operating activities | 170304 | 215423 |
| Cash flows from investing activities: |  |  |
| &nbsp;&nbsp;&nbsp;Interest received | 4331 | 4850 |
| &nbsp;&nbsp;&nbsp;Dividends received | 206 | 250 |
| &nbsp;&nbsp;&nbsp;Acquisition of property, plant and equipment | (57441) | (47913) |
| &nbsp;&nbsp;&nbsp;Proceeds from sales of property, plant and equipment | 9 | 6385 |
| &nbsp;&nbsp;&nbsp;Acquisition of intangible assets | (80357) | (27155) |
| &nbsp;&nbsp;&nbsp;Acquisition of option to license | (15693) |  |
| &nbsp;&nbsp;&nbsp;Acquisition of investments | (12980) | (215) |
| &nbsp;&nbsp;&nbsp;Proceeds from sales and redemption of investments | 5317 | 1128 |
| &nbsp;&nbsp;&nbsp;Proceeds from sales of business, net of cash and cash equivalents divested | 2941 | 29291 |
| &nbsp;&nbsp;&nbsp;Payments for the settlement of forward exchange contracts designated as net investment hedges | (2999) |  |
| &nbsp;&nbsp;&nbsp;Other, net | (28) | 186 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net cash used in investing activities | (156693) | (33193) |

---

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Three-month

Period Ended June 30, 2025 (Consolidated)

---

| | | |
|:---|:---|:---|
| | **JPY (millions)** | **JPY (millions)** |
| | **Three-month Period Ended June 30,** | **Three-month Period Ended June 30,** |
| | **2024** | **2025** |
| Cash flows from financing activities: |  |  |
| &nbsp;&nbsp;&nbsp;Net decrease in short-term loans and commercial papers | (17000) | (46032) |
| &nbsp;&nbsp;&nbsp;Proceeds from issuance of bonds and long-term loans | 507638 | 183555 |
| &nbsp;&nbsp;&nbsp;Repayments of bonds and long-term loans | (50109) | (125296) |
| &nbsp;&nbsp;&nbsp;Proceeds from the settlement of cross currency interest rate swaps related to bonds and loans | 46880 |  |
| &nbsp;&nbsp;&nbsp;Acquisition of treasury shares | (1882) | (51603) |
| &nbsp;&nbsp;&nbsp;Interest paid | (15466) | (16692) |
| &nbsp;&nbsp;&nbsp;Dividends paid | (138110) | (145295) |
| &nbsp;&nbsp;&nbsp;Repayments of lease liabilities | (10916) | (12205) |
| &nbsp;&nbsp;&nbsp;Other, net | (4654) | (1332) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net cash from (used in) financing activities | 316381 | (214900) |
| Net increase (decrease) in cash and cash equivalents | 329991 | (32670) |
| Cash and cash equivalents at the beginning of the year | 457800 | 385113 |
| Effects of exchange rate changes on cash and cash equivalents | 17220 | (2435) |
| Cash and cash equivalents at the end of the period | 805012 | 350008 |
| Cash and cash equivalents reclassified to assets held for sale | (740) |  |
| Cash and cash equivalents at the end of the period<br>(Condensed interim consolidated statements of financial position) | 804272 | 350008 |

---

------

Takeda Pharmaceutical Company Limited (4502)

Earnings Report (*Kessan Tanshin*) for the Three-month

Period Ended June 30, 2025 (Consolidated)

**(6) Notes to Condensed Interim Consolidated Financial Statements**

(Significant Uncertainty Regarding Going Concern Assumption)

Not applicable.

(Material Accounting Policies)

Material accounting policies adopted for the condensed interim consolidated financial statements are the same as those adopted for the consolidated financial statements as of and for the fiscal year ended March 31, 2025.

Takeda calculated income tax expenses for the three-month period ended June 30, 2025, based on the estimated average annual effective tax rate.

(Operating Segment Information)

Takeda comprises a single operating segment and is engaged in the research, development, manufacturing, marketing and out-licensing of pharmaceutical products. This is consistent with how the financial information is viewed in allocating resources, measuring performance, and forecasting future periods by the CEO who is Takeda's Chief Operating Decision Maker.

(Significant Changes in Equity Attributable to Owners of the Company)

Not applicable.

(Significant Subsequent Events)

On July 2, 2025, Takeda issued unsecured U.S. dollar-denominated senior guaranteed notes (the "Notes") in an aggregate principal amount of USD 2,400 million outlined below, through its indirect wholly owned finance subsidiary Takeda U.S. Financing, Inc. Payment of the principal of and interest on the Notes is fully guaranteed by Takeda.

In July 2025, the proceeds of the Notes were primarily used to repay USD 500 million Bilateral Loan, and redeem commercial paper drawings. The impact from these repayment and redemptions on the consolidated statements of profit or loss was not material.

---

| | | |
|:---|:---|:---|
| | Unsecured U.S. Dollar-Denominated Senior Guaranteed Notes Due 2035 | Unsecured U.S. Dollar-Denominated Senior Guaranteed Notes Due 2055 |
| &nbsp;&nbsp;Issue Amount | &nbsp;&nbsp;USD 1,650 million | &nbsp;&nbsp;USD 750 million |
| &nbsp;&nbsp;Coupon | &nbsp;&nbsp;5.200% per annum | &nbsp;&nbsp;5.900% per annum |
| &nbsp;&nbsp;Issue Price | &nbsp;&nbsp;99.644% of the principal amount | &nbsp;&nbsp;99.734% of the principal amount |
| &nbsp;&nbsp;Maturity Date | &nbsp;&nbsp;July 7, 2035 | &nbsp;&nbsp;July 7, 2055 |

---

## Exhibit 99.1

**Exhibit 99.1**

![logo.jpg](logo.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;**FINANCIAL APPENDIX**

---

| | |
|:---|:---|
| **Definition of Non-IFRS Measures** | |
| Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations | A-[1](#i37d427512a5d421ea9c9561c17bc6deb_133) |
| **Reconciliations and Other Financial Information** |  |
| FY2025 Q1 Reported Results with CER % Change | A-[4](#i37d427512a5d421ea9c9561c17bc6deb_22539988370809) |
| FY2025 Q1 Core Results with CER % Change | A-[5](#i37d427512a5d421ea9c9561c17bc6deb_22539988370831) |
| FY2025 Q1 Reconciliation from Reported to Core | A-[6](#i37d427512a5d421ea9c9561c17bc6deb_22539988370861) |
| FY2024 Q1 Reconciliation from Reported to Core | A-[7](#i37d427512a5d421ea9c9561c17bc6deb_22539988370887) |
| FY2025 Q1 Adjusted Free Cash Flow | A-[8](#i37d427512a5d421ea9c9561c17bc6deb_151) |
| FY2025 Q1 Adjusted Net Debt to Adjusted EBITDA | A-[9](#i37d427512a5d421ea9c9561c17bc6deb_154) |
| FY2024 Adjusted Net Debt to Adjusted EBITDA | A-[10](#i37d427512a5d421ea9c9561c17bc6deb_14293651162420) |
| FY2025 Q1 Net Profit to Adjusted EBITDA Bridge | A-[11](#i37d427512a5d421ea9c9561c17bc6deb_160) |
| FY2025 Q1 Net Profit to Adjusted EBITDA LTM Bridge | A-[12](#i37d427512a5d421ea9c9561c17bc6deb_18691697673462) |
| FY2025 Q1 CAPEX, Depreciation and Amortization and Impairment Losses | A-[13](#i37d427512a5d421ea9c9561c17bc6deb_169) |
| FY2025 Full Year Detailed Forecast | A-[14](#i37d427512a5d421ea9c9561c17bc6deb_1099511629391) |
| FY2025 Full Year Reconciliation from Reported Operating Profit to Core Operating Profit Forecast | A-[15](#i37d427512a5d421ea9c9561c17bc6deb_178) |
| FY2025 Full Year FX Rates Assumptions and Currency Sensitivity vs. Forecast | A-[16](#i37d427512a5d421ea9c9561c17bc6deb_166) |
| **Important Notice** |  |
| Important Notice, Forward-Looking Statements, Financial Information and Non-IFRS Measures, and Medical Information | A-[17](#i37d427512a5d421ea9c9561c17bc6deb_181) |

---

------

![logo.jpg](logo.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;**Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations**<br>

**Core Financial Measures**

Takeda's Core Financial Measures, particularly **Core Revenue**, **Core Operating Profit**, **Core Net Profit for the Year attributable to owners of the Company** and **Core EPS**, exclude revenue from divestments, amortization and impairment losses on intangible assets associated with products (including in-process R&D) and other impacts unrelated to the underlying trends and business performance of Takeda's core operations, such as non-recurring items, purchase accounting effects and transaction related costs. **Core Revenue** represents revenue adjusted to exclude revenue items unrelated to the underlying trends and business performance of Takeda's core operations (primarily revenue or related adjustments associated with divestments and liquidations). **Core Operating Profit** represents operating profit adjusted to exclude other operating expenses and income, amortization and impairment losses on intangible assets associated with products (including in-process R&D) and non-cash items or items unrelated to the underlying trends and business performance of Takeda's core operations. **Core Net Profit for the Year attributable to owners of the Company** represents net profit for the year attributable to owners of the Company, adjusted to eliminate the impact of items excluded in the calculation of Core Operating Profit and other non-operating items (e.g. amongst other items, fair value adjustments and the imputed financial charge related to contingent consideration) that are unusual, non-recurring in nature or unrelated to the underlying trends and business performance of Takeda's ongoing operations and the tax effect of each of the adjustments. **Core EPS** is calculated by dividing Core Net Profit for the Year attributable to owners of the Company by the average outstanding shares (excluding treasury shares) of the reporting periods presented.

Takeda presents its Core Financial Measures because Takeda believes that these measures are useful to understanding its business without the effect of items that Takeda considers to be unrelated to the underlying trends and business performance of its core operations, including items (i) which may vary significantly from year-to-year or may not occur in each year or (ii) whose recognition Takeda believes is largely uncorrelated to trends in the underlying performance of our core business. Takeda believes that similar measures are frequently used by other companies in its industry and that providing these measures helps investors evaluate Takeda's performance against not only its performance in prior years but on a similar basis as its competitors. Takeda also presents Core Financial Measures because these measures are used by Takeda for budgetary planning and compensation purposes (i.e., certain targets for the purposes of Takeda's Short-Term Incentive and Long-Term Incentive compensation programs, including incentive compensation of the CEO and CFO, are set in relation to the results of Takeda's Core Financial Measures).

**Constant Exchange Rate ("CER") Change**

**CER Change** eliminates the effect of foreign exchange rates from year-over-year comparisons by translating financial results in accordance with IFRS or Core (non-IFRS) financial measures for the current period using corresponding exchange rates in the same period of the previous fiscal year, except for the results of operations of subsidiaries in countries experiencing hyperinflation and for which IAS29, Financial Reporting in Hyperinflation Economies, is applied.

Takeda presents CER change because we believe that this measure is useful to investors to better understand the effect of exchange rates on our business and to understand how our results of operations might have changed from year to year without the effect of fluctuations in exchange rates. These are the primary ways in which our management uses these measures to evaluate our results of operations. We also believe that this is a useful measure for investors as similar performance measures are frequently used by securities analysts, investors and other interested parties in the evaluation of the results of operations of other companies in our industry (many of whom similarly present measures that adjust for the effect of exchange rates).

The usefulness of this presentation has significant limitations including but not limited to, that while CER change is calculated using the same exchange rates used to calculate financial results as presented under IFRS for the previous fiscal year, this does not necessarily mean that the transactions entered into during the relevant fiscal year could have been entered into or would have been recorded at the same exchange rates. Moreover, other companies in our industry using similarly titled measures may define and calculate those measures differently than we do and therefore such measures may not be directly comparable. Accordingly, CER change should not be considered in isolation and is not, and should not be viewed as, a substitute for change in financial results as prepared and presented in accordance with IFRS.

------

![logo.jpg](logo.jpg)

**Free Cash Flow and Adjusted Free Cash Flow**

Takeda defines **Free Cash Flow** as cash flows from operating activities less acquisition of property, plant and equipment ("PP&E"). Takeda defines **Adjusted Free Cash Flow** as cash flows from operating activities, subtracting payments for acquisition of PP&E, intangible assets, investments (excluding debt investments classified as Level 1 in the fair value hierarchy), shares in associates and businesses, net of cash and cash equivalents acquired and other transactional payments deemed related or similar in substance thereto as well as adding proceeds from sales of PP&E, sales and redemption of investments (excluding debt investments classified as Level 1 in the fair value hierarchy), sales of shares in associates and sales of businesses, net of cash and cash equivalents divested and further adjusting for the movement of any other cash that is not available to Takeda's immediate or general business use.

Takeda presents Free Cash Flow and Adjusted Free Cash Flow because Takeda believes that these measures are useful to investors as similar measures of liquidity are frequently used by securities analysts, investors and other interested parties in the evaluation of companies in our industry. Adjusted Free Cash Flow is also used by our management to evaluate our liquidity and our cash flows, particularly as they relate to our ability to meet our liquidity requirements and to support our capital allocation policies. Takeda also believes that Free Cash Flow and Adjusted Free Cash Flow are helpful to investors in understanding how our strategic acquisitions and divestitures of businesses contribute to our cash flows and liquidity.

The usefulness of Free Cash Flow and Adjusted Free Cash Flow to investors has significant limitations including, but not limited to, (i) they may not be comparable to similarly titled measures used by other companies, including those in our industry, (ii) they do not reflect the effect of our current and future contractual and other commitments requiring the use or allocation of capital and (iii) the addition of proceeds from sales and redemption of investments and the proceeds from sales of business, net of cash and cash equivalents divested do not represent cash received from our core ongoing operations. Free Cash Flow and Adjusted Free Cash Flow should not be considered in isolation and are not, and should not be viewed as, substitutes for cash flows from operating activities or any other measure of liquidity presented in accordance with IFRS. The most directly comparable measure under IFRS for Free Cash Flow and Adjusted Free Cash Flow is net cash from operating activities.

**EBITDA and Adjusted EBITDA**

Takeda defines **EBITDA** as consolidated net profit before income tax expenses, depreciation and amortization and net interest expense. Takeda defines **Adjusted EBITDA** as EBITDA further adjusted to exclude impairment losses, other operating income and expenses (excluding depreciation and amortization, as well as impairment losses), finance income and expenses (excluding net interest expense), our share of profit or loss of investments accounted for using the equity method, other non-cash items such as non-cash equity-based compensation expense, and other items that management believes are unrelated to our core operations, including EBITDA from divested products, purchase accounting effects and transaction related costs.

Takeda presents EBITDA and Adjusted EBITDA because Takeda believes that these measures are useful to investors as they are frequently used by securities analysts, investors and other interested parties in the evaluation of companies in our industry. Primarily, Adjusted EBITDA is used by Takeda for the purposes of monitoring its financial leverage. Takeda further believes that Adjusted EBITDA is helpful to investors in identifying trends in its business that could otherwise be obscured by certain items unrelated to ongoing operations because they are highly variable, difficult to predict, may substantially impact our results of operations and may limit the ability to evaluate our performance from one period to another on a consistent basis.

The usefulness of EBITDA and Adjusted EBITDA to investors has significant limitations including, but not limited to, (i) they may not be comparable to similarly titled measures used by other companies, including those in the pharmaceutical industry, (ii) they exclude financial information and events, such as the effects of an acquisition, or amortization of intangible assets, that some may consider important in evaluating Takeda's performance, value or prospects for the future, (iii) they exclude items or types of items that may continue to occur from period to period in the future and (iv) they may not include all items which investors may consider important to an understanding of our results of operations, or may not exclude all items which investors may not consider important for such understanding. EBITDA and Adjusted EBITDA should not be considered in isolation and are not, and should not be viewed as, substitutes for operating income, net profit for the year or any other measure of performance presented in accordance with IFRS. The most closely comparable measure presented in accordance with IFRS is net profit for the year.

------

![logo.jpg](logo.jpg)

**Net Debt and Adjusted Net Debt**

Takeda defines **Net Debt** as the book value of bonds and loans on consolidated statements of financial position adjusted only for cash and cash equivalents and **Adjusted Net Debt** first by calculating the sum of the current and non-current portions of bonds and loans as shown on our consolidated statement of financial position, which is then adjusted to reflect (i) the use of prior 12-month average exchange rates for non-JPY debt outstanding at the beginning of the period and the use of relevant spot rates for new non-JPY debt incurred and existing non-JPY debt redeemed during the reporting period, which reflects the methodology our management uses to monitor our leverage, and (ii) the "equity credit" applied to Takeda's "hybrid" subordinated indebtedness by S&P Global Rating Japan in recognition of the equity-like features of those instruments pursuant to such agency's ratings methodology. To calculate Adjusted Net Debt, Takeda deducts from this figure cash and cash equivalents, excluding cash temporarily held by Takeda on behalf of third parties related to vaccine operations and to the trade receivables sales program, and debt investments classified as Level 1 in the fair value hierarchy being recorded as Other Financial Assets.

Takeda presents Net Debt and Adjusted Net Debt because Takeda believes that these measures are useful to investors in that our management uses it to monitor and evaluate our indebtedness, net of cash and cash equivalents and, in conjunction with Adjusted EBITDA, to monitor our financial leverage (for the avoidance of doubt, Adjusted Net Debt and the ratio of Adjusted Net Debt to Adjusted EBITDA are not intended to be indicators of Takeda's liquidity). Takeda also believes that similar measures of indebtedness are frequently used by securities analysts, investors and other interested parties in the evaluation of companies in our industry. Particularly following the acquisition of Shire, investors, analysts and, in particular, ratings agencies, have closely monitored Takeda's leverage, as represented by the ratio of its Adjusted Net Debt to Adjusted EBITDA. In light of the weight given by ratings agencies in particular to this ratio, Takeda believes that such information is useful to investors to help understand not only Takeda's financial leverage, but also how ratings agencies evaluate the level of financial leverage in evaluating Takeda's quality of credit. Accordingly, as described below, Takeda includes an adjustment to its Adjusted Net Debt to reflect the "equity credit" afforded to certain of its subordinated indebtedness by ratings agencies (such indebtedness does not qualify for treatment as equity under IFRS).

The usefulness of Adjusted Net Debt to investors has significant limitations including, but not limited to, (i) it may not be comparable to similarly titled measures used by other companies, including those in the pharmaceutical industry, (ii) it does not reflect the amounts of interest payments to be paid on Takeda's indebtedness, (iii) it does not reflect any restrictions on Takeda's ability to prepay or redeem any of our indebtedness, (iv) it does not reflect any fees, costs or other expenses that Takeda may incur in converting cash equivalents to cash, in converting cash from one currency into another or in moving cash within our consolidated group, (v) it applies to gross debt an adjustment for average foreign exchange rates which, although consistent with Takeda's financing agreements, does not reflect the actual rates at which Takeda would be able to convert one currency into another and (vi) it reflects an equity credit despite the fact that Takeda's subordinated bonds are not eligible for equity treatment under IFRS, although Takeda believes this adjustment to be reasonable and useful to investors. Adjusted Net Debt should not be considered in isolation and is not, and should not be viewed as, a substitute for bonds and loans or any other measure of indebtedness presented in accordance with IFRS. The most directly comparable measures under IFRS for Net Debt is bonds and loans.

**U.S. Dollar Convenience Translations**

In the Financial Appendix, certain amounts presented in Japanese yen have been translated to U.S. dollars solely for the convenience of the reader at an exchange rate of 1USD = 144.17 JPY, the Noon Buying Rate certified by the Federal Reserve Bank of New York on June 30, 2025. The rate and methodologies used for the convenience translations differ from the currency exchange rates and translation methodologies under IFRS used for the preparation of the condensed interim consolidated financial statements. The translation should not be construed as a representation that the Japanese yen amounts could be converted into U.S. dollars at this or any other rate.

------

![logo.jpg](logo.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q1 Reported Results with CER % Change**<br>

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| **(Billion JPY, except EPS)** | **FY2024<br>Q1** | **FY2025<br>Q1** | **AER** | **AER** | **CER** | **(Million USD,**<br>**except EPS)**<br>**FY2025 Q1**<br>**Convenience**<br>**USD Translation** |
| **(Billion JPY, except EPS)** | **FY2024<br>Q1** | **FY2025<br>Q1** | **JPY Change** | **% Change** | **% Change** | **(Million USD,**<br>**except EPS)**<br>**FY2025 Q1**<br>**Convenience**<br>**USD Translation** |
| Revenue | 1208.0 | 1106.7 | (101.3) | (8.4)% | (3.7)% | 7676 |
| &nbsp;&nbsp;Cost of sales | (387.0) | (384.7) | 2.3 | 0.6% | (4.3)% | (2668) |
| Gross profit | 821.0 | 722.0 | (99.0) | (12.1)% | (7.6)% | 5008 |
| *Margin* | *68.0 %* | *65.2 %* |  | *(2.7) pp* | *(2.7) pp* | *65.2 %* |
| &nbsp;&nbsp;SG&A expenses | (270.0) | (255.9) | 14.1 | 5.2% | 0.0% | (1775) |
| &nbsp;&nbsp;R&D expenses | (168.5) | (143.9) | 24.6 | 14.6% | 9.7% | (998) |
| &nbsp;&nbsp;Amortization of intangible assets associated with products | (138.6) | (129.3) | 9.3 | 6.7% | 1.1% | (897) |
| &nbsp;&nbsp;Impairment losses on intangible assets associated with products<sup>\*1</sup> | (24.2) | (2.3) | 21.9 | 90.5% | 89.6% | (16) |
| &nbsp;&nbsp;Other operating income | 10.9 | 22.0 | 11.2 | 102.7% | 102.1% | 153 |
| &nbsp;&nbsp;Other operating expenses | (64.3) | (28.1) | 36.2 | 56.3% | 53.6% | (195) |
| Operating profit | 166.3 | 184.6 | 18.2 | 11.0% | 14.0% | 1280 |
| *Margin* | *13.8 %* | *16.7 %* |  | *2.9 pp* | *2.5 pp* | *16.7 %* |
| &nbsp;&nbsp;Finance income | 30.7 | 73.8 | 43.1 | 140.4% | 141.4% | 512 |
| &nbsp;&nbsp;Finance expenses | (59.7) | (107.2) | (47.5) | (79.5)% | (80.2)% | (743) |
| &nbsp;&nbsp;Share of profit (loss) of investments accounted for using the equity method | (0.7) | (0.5) | 0.2 | 24.7% | 69.6% | (4) |
| Profit before tax | 136.6 | 150.6 | 14.0 | 10.3% | 14.1% | 1045 |
| &nbsp;&nbsp;Income tax (expenses) benefit | (41.3) | (26.4) | 15.0 | 36.2% | 32.9% | (183) |
| Net profit for the period | 95.3 | 124.3 | 29.0 | 30.4% | 34.5% | 862 |
| &nbsp;&nbsp;Non-controlling interests | (0.1) | (0.0) | 0.0 | 29.9% | 23.7% | (0) |
| Net profit attributable to owners of the Company | 95.2 | 124.2 | 29.0 | 30.4% | 34.5% | 862 |
| Basic EPS (JPY or USD) | 60.71 | 79.40 | 18.69 | 30.8% | 34.9% | 0.55 |
| \*1 Includes in-process R&D | \*1 Includes in-process R&D | \*1 Includes in-process R&D | \*1 Includes in-process R&D | \*1 Includes in-process R&D | \*1 Includes in-process R&D | \*1 Includes in-process R&D |
| The amount of change and percentage change based on Actual Exchange Rates are presented in "AER" (which is presented in accordance with IFRS) and percentage change based on Constant Exchange Rate (which is a non-IFRS measure) is presented in "CER". Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations*, for the definition of the "Constant Exchange Rate change". | The amount of change and percentage change based on Actual Exchange Rates are presented in "AER" (which is presented in accordance with IFRS) and percentage change based on Constant Exchange Rate (which is a non-IFRS measure) is presented in "CER". Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations*, for the definition of the "Constant Exchange Rate change". | The amount of change and percentage change based on Actual Exchange Rates are presented in "AER" (which is presented in accordance with IFRS) and percentage change based on Constant Exchange Rate (which is a non-IFRS measure) is presented in "CER". Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations*, for the definition of the "Constant Exchange Rate change". | The amount of change and percentage change based on Actual Exchange Rates are presented in "AER" (which is presented in accordance with IFRS) and percentage change based on Constant Exchange Rate (which is a non-IFRS measure) is presented in "CER". Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations*, for the definition of the "Constant Exchange Rate change". | The amount of change and percentage change based on Actual Exchange Rates are presented in "AER" (which is presented in accordance with IFRS) and percentage change based on Constant Exchange Rate (which is a non-IFRS measure) is presented in "CER". Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations*, for the definition of the "Constant Exchange Rate change". | The amount of change and percentage change based on Actual Exchange Rates are presented in "AER" (which is presented in accordance with IFRS) and percentage change based on Constant Exchange Rate (which is a non-IFRS measure) is presented in "CER". Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations*, for the definition of the "Constant Exchange Rate change". | The amount of change and percentage change based on Actual Exchange Rates are presented in "AER" (which is presented in accordance with IFRS) and percentage change based on Constant Exchange Rate (which is a non-IFRS measure) is presented in "CER". Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations*, for the definition of the "Constant Exchange Rate change". |
| % change is presented as positive when favorable to profits, and negative when unfavorable to profits. | % change is presented as positive when favorable to profits, and negative when unfavorable to profits. | % change is presented as positive when favorable to profits, and negative when unfavorable to profits. | % change is presented as positive when favorable to profits, and negative when unfavorable to profits. | % change is presented as positive when favorable to profits, and negative when unfavorable to profits. | % change is presented as positive when favorable to profits, and negative when unfavorable to profits. | % change is presented as positive when favorable to profits, and negative when unfavorable to profits. |

---

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![logo.jpg](logo.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q1 Core Results with CER % Change**

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| **(Billion JPY, except EPS)** | **FY2024<br>Q1** | **FY2025<br>Q1** | **AER** | **AER** | **CER** | **(Million USD,**<br>**except EPS)**<br>**FY2025 Q1** <br>**Convenience**<br>**USD Translation** |
| **(Billion JPY, except EPS)** | **FY2024<br>Q1** | **FY2025<br>Q1** | **JPY Change** | **% Change** | **% Change** | **(Million USD,**<br>**except EPS)**<br>**FY2025 Q1** <br>**Convenience**<br>**USD Translation** |
| Revenue | 1208.0 | 1106.7 | (101.3) | (8.4)% | (3.7)% | 7676 |
| &nbsp;&nbsp;Cost of sales | (387.1) | (384.9) | 2.2 | 0.6% | (4.4)% | (2670) |
| Gross profit | 820.9 | 721.8 | (99.1) | (12.1)% | (7.6)% | 5006 |
| *Margin* | *68.0 %* | *65.2 %* |  | *(2.7) pp* | *(2.7) pp* | *65.2 %* |
| &nbsp;&nbsp;SG&A expenses | (270.2) | (256.0) | 14.1 | 5.2% | 0.0% | (1776) |
| &nbsp;&nbsp;R&D expenses | (168.5) | (143.9) | 24.6 | 14.6% | 9.7% | (998) |
| Operating profit | 382.3 | 321.8 | (60.4) | (15.8)% | (11.9)% | 2232 |
| *Margin* | *31.6 %* | *29.1 %* |  | *(2.6) pp* | *(2.7) pp* | *29.1 %* |
| &nbsp;&nbsp;Finance income | 25.0 | 73.0 | 48.0 | 191.7% | 192.9% | 507 |
| &nbsp;&nbsp;Finance expenses | (55.1) | (104.3) | (49.2) | (89.4)% | (90.0)% | (724) |
| &nbsp;&nbsp;Share of profit (loss) of investments accounted for using the equity method | 0.4 | (0.1) | (0.5) | ― | (44.8)% | (1) |
| Profit before tax | 352.6 | 290.4 | (62.2) | (17.6)% | (13.4)% | 2014 |
| &nbsp;&nbsp;Income tax (expenses) benefit | (75.7) | (53.3) | 22.4 | 29.6% | 24.8% | (370) |
| Net profit for the period | 276.9 | 237.1 | (39.8) | (14.4)% | (10.3)% | 1644 |
| &nbsp;&nbsp;Non-controlling interests | (0.1) | (0.0) | 0.0 | 29.9% | 23.7% | (0) |
| Net profit attributable to owners of the Company | 276.8 | 237.0 | (39.8) | (14.4)% | (10.3)% | 1644 |
| Basic EPS (JPY or USD) | 176 | 151 | (25) | (14.1)% | (10.0)% | 1.05 |
| The amount of change and percentage change based on Actual Exchange Rates are presented in "AER" (which is presented in accordance with IFRS) and percentage change based on Constant Exchange Rate (which is a non-IFRS measure) is presented in "CER". Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations*, for the definition of the "Constant Exchange Rate change". | The amount of change and percentage change based on Actual Exchange Rates are presented in "AER" (which is presented in accordance with IFRS) and percentage change based on Constant Exchange Rate (which is a non-IFRS measure) is presented in "CER". Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations*, for the definition of the "Constant Exchange Rate change". | The amount of change and percentage change based on Actual Exchange Rates are presented in "AER" (which is presented in accordance with IFRS) and percentage change based on Constant Exchange Rate (which is a non-IFRS measure) is presented in "CER". Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations*, for the definition of the "Constant Exchange Rate change". | The amount of change and percentage change based on Actual Exchange Rates are presented in "AER" (which is presented in accordance with IFRS) and percentage change based on Constant Exchange Rate (which is a non-IFRS measure) is presented in "CER". Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations*, for the definition of the "Constant Exchange Rate change". | The amount of change and percentage change based on Actual Exchange Rates are presented in "AER" (which is presented in accordance with IFRS) and percentage change based on Constant Exchange Rate (which is a non-IFRS measure) is presented in "CER". Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations*, for the definition of the "Constant Exchange Rate change". | The amount of change and percentage change based on Actual Exchange Rates are presented in "AER" (which is presented in accordance with IFRS) and percentage change based on Constant Exchange Rate (which is a non-IFRS measure) is presented in "CER". Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations*, for the definition of the "Constant Exchange Rate change". | The amount of change and percentage change based on Actual Exchange Rates are presented in "AER" (which is presented in accordance with IFRS) and percentage change based on Constant Exchange Rate (which is a non-IFRS measure) is presented in "CER". Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations*, for the definition of the "Constant Exchange Rate change". |
| % change is presented as positive when favorable to profits, and negative when unfavorable to profits. | % change is presented as positive when favorable to profits, and negative when unfavorable to profits. | % change is presented as positive when favorable to profits, and negative when unfavorable to profits. | % change is presented as positive when favorable to profits, and negative when unfavorable to profits. | % change is presented as positive when favorable to profits, and negative when unfavorable to profits. | % change is presented as positive when favorable to profits, and negative when unfavorable to profits. | % change is presented as positive when favorable to profits, and negative when unfavorable to profits. |

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![logo.jpg](logo.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q1 Reconciliation from Reported to Core**<br>

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| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| **(Billion JPY, except EPS and number of shares)** | **Reported** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Core** |
| **(Billion JPY, except EPS and number of shares)** | **Reported** | Amortization of<br>intangible<br>assets | Impairment of<br>intangible<br>assets | Other<br>operating income/<br>expenses | Others | **Core** |
| Revenue | 1106.7 |  |  |  |  | 1106.7 |
| &nbsp;&nbsp;Cost of sales | (384.7) |  |  |  | (0.2) | (384.9) |
| Gross profit | 722.0 |  |  |  | (0.2) | 721.8 |
| &nbsp;&nbsp;SG&A expenses | (255.9) |  |  |  | (0.1) | (256.0) |
| &nbsp;&nbsp;R&D expenses | (143.9) |  |  |  | (0.0) | (143.9) |
| &nbsp;&nbsp;Amortization of intangible assets associated with products | (129.3) | 129.3 |  |  |  |  |
| &nbsp;&nbsp;Impairment losses on intangible assets associated with products<sup>\*1</sup> | (2.3) |  | 2.3 |  |  |  |
| &nbsp;&nbsp;Other operating income | 22.0 |  |  | (22.0) |  |  |
| &nbsp;&nbsp;Other operating expenses | (28.1) |  |  | 28.1 |  |  |
| Operating profit | 184.6 | 129.3 | 2.3 | 6.0 | (0.4) | 321.8 |
| *Margin* | 16.7% |  |  |  |  | 29.1% |
| &nbsp;&nbsp;Finance income and (expenses), net | (33.4) |  |  |  | 2.1 | (31.3) |
| &nbsp;&nbsp;Share of profit (loss) of investments accounted for using the equity method | (0.5) |  |  |  | 0.4 | (0.1) |
| Profit before tax | 150.6 | 129.3 | 2.3 | 6.0 | 2.1 | 290.4 |
| &nbsp;&nbsp;Income tax (expenses) benefit | (26.4) | (27.5) | (0.5) | 1.9 | (0.9) | (53.3) |
| &nbsp;&nbsp;Non-controlling interests | (0.0) |  |  |  |  | (0.0) |
| Net profit attributable to owners of the Company | 124.2 | 101.8 | 1.8 | 7.9 | 1.2 | 237.0 |
| Basic EPS (JPY) | 79 |  |  |  |  | 151 |
| Number of shares (millions) | 1565 |  |  |  |  | 1565 |

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\*1 Includes in-process R&D.

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![logo.jpg](logo.jpg)

&nbsp;&nbsp;&nbsp;&nbsp;**FY2024 Q1 Reconciliation from Reported to Core**<br>

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| **(Billion JPY, except EPS and number of shares)** | **Reported** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Core** |
| **(Billion JPY, except EPS and number of shares)** | **Reported** | Amortization of<br>intangible<br>assets | Impairment of<br>intangible<br>assets | Other<br>operating income/<br>expenses | Others | **Core** |
| Revenue | 1208.0 |  |  |  |  | 1208.0 |
| &nbsp;&nbsp;Cost of sales | (387.0) |  |  |  | (0.1) | (387.1) |
| Gross profit | 821.0 |  |  |  | (0.1) | 820.9 |
| &nbsp;&nbsp;SG&A expenses | (270.0) |  |  |  | (0.1) | (270.2) |
| &nbsp;&nbsp;R&D expenses | (168.5) |  |  |  | (0.0) | (168.5) |
| &nbsp;&nbsp;Amortization of intangible assets associated with products | (138.6) | 138.6 |  |  |  |  |
| &nbsp;&nbsp;Impairment losses on intangible assets associated with products<sup>\*1</sup> | (24.2) |  | 24.2 |  |  |  |
| &nbsp;&nbsp;Other operating income | 10.9 |  |  | (10.9) |  |  |
| &nbsp;&nbsp;Other operating expenses | (64.3) |  |  | 64.3 |  |  |
| Operating profit | 166.3 | 138.6 | 24.2 | 53.4 | (0.3) | 382.3 |
| *Margin* | 13.8% |  |  |  |  | 31.6% |
| &nbsp;&nbsp;Finance income and (expenses), net | (29.0) |  |  |  | (1.0) | (30.1) |
| &nbsp;&nbsp;Share of profit (loss) of investments accounted for using the equity method | (0.7) |  |  |  | 1.1 | 0.4 |
| Profit before tax | 136.6 | 138.6 | 24.2 | 53.4 | (0.2) | 352.6 |
| &nbsp;&nbsp;Income tax (expenses) benefit | (41.3) | (29.0) | (7.2) | (11.4) | 13.2 | (75.7) |
| &nbsp;&nbsp;Non-controlling interests | (0.1) |  |  |  |  | (0.1) |
| Net profit attributable to owners of the Company | 95.2 | 109.6 | 17.0 | 42.0 | 13.0 | 276.8 |
| Basic EPS (JPY) | 61 |  |  |  |  | 176 |
| Number of shares (millions) | 1569 |  |  |  |  | 1569 |

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\*1 Includes in-process R&D.

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![logo.jpg](logo.jpg)

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| | | | | | |
|:---|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q1 Adjusted Free Cash Flow** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q1 Adjusted Free Cash Flow** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q1 Adjusted Free Cash Flow** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q1 Adjusted Free Cash Flow** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q1 Adjusted Free Cash Flow** | |
| **(Billion JPY)** | **FY2024<br>Q1** | **FY2025<br>Q1** | **JPY Change** | **% Change** |<br>**(Million USD)<br>FY2025 Q1<br>Convenience USD Translation** |
| Net profit | 95.3 | 124.3 | 29.0 | 30.4% | 862 |
| &nbsp;&nbsp;Depreciation, amortization and impairment losses | 218.2 | 184.0 | (34.2) |  | 1276 |
| &nbsp;&nbsp;Decrease (increase) in trade working capital | (95.3) | 7.2 | 102.5 |  | 50 |
| &nbsp;&nbsp;Income taxes paid | (37.8) | (36.7) | 1.2 |  | (254) |
| &nbsp;&nbsp;Tax refunds and interest on tax refunds received | 2.3 | 3.7 | 1.3 |  | 25 |
| &nbsp;&nbsp;Other | (12.4) | (67.1) | (54.7) |  | (465) |
| Net cash from operating activities (Operating Cash Flow) | 170.3 | 215.4 | 45.1 | 26.5% | 1494 |
| &nbsp;&nbsp;Acquisition of PP&E | (57.4) | (47.9) | 9.5 |  | (332) |
| Free Cash Flow<sup>\*1</sup> | 112.9 | 167.5 | 54.6 | 48.4% | 1162 |
| &nbsp;&nbsp;Adjustment for cash temporarily held by Takeda on behalf of third parties<sup>\*2</sup> | 11.6 | 13.2 | 1.6 |  | 91 |
| &nbsp;&nbsp;Proceeds from sales of PP&E | 0.0 | 6.4 | 6.4 |  | 44 |
| &nbsp;&nbsp;Acquisition of intangible assets<sup>\*3</sup> | (80.4) | (27.2) | 53.2 |  | (188) |
| &nbsp;&nbsp;Acquisition of option to license | (15.7) |  | 15.7 |  |  |
| &nbsp;&nbsp;Acquisition of investments | (13.0) | (0.2) | 12.8 |  | (1) |
| &nbsp;&nbsp;Proceeds from sales and redemption of investments | 5.3 | 1.1 | (4.2) |  | 8 |
| &nbsp;&nbsp;Proceeds from sales of business, net of cash and cash equivalents divested | 2.9 | 29.3 | 26.4 |  | 203 |
| Adjusted Free Cash Flow<sup>\*1</sup> | 23.7 | 190.1 | 166.5 | 703.6% | 1319 |
| \*1 Please refer to Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations for the definitions of Free Cash Flow and Adjusted Free Cash Flow. | \*1 Please refer to Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations for the definitions of Free Cash Flow and Adjusted Free Cash Flow. | \*1 Please refer to Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations for the definitions of Free Cash Flow and Adjusted Free Cash Flow. | \*1 Please refer to Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations for the definitions of Free Cash Flow and Adjusted Free Cash Flow. | \*1 Please refer to Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations for the definitions of Free Cash Flow and Adjusted Free Cash Flow. | \*1 Please refer to Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations for the definitions of Free Cash Flow and Adjusted Free Cash Flow. |
| \*2 Adjustment for cash temporarily held by Takeda on behalf of third parties refers to changes in cash balances that are temporarily held by Takeda on behalf of third parties related to vaccine operations and the trade receivables sales program, which are not available to Takeda's immediate or general business use. | \*2 Adjustment for cash temporarily held by Takeda on behalf of third parties refers to changes in cash balances that are temporarily held by Takeda on behalf of third parties related to vaccine operations and the trade receivables sales program, which are not available to Takeda's immediate or general business use. | \*2 Adjustment for cash temporarily held by Takeda on behalf of third parties refers to changes in cash balances that are temporarily held by Takeda on behalf of third parties related to vaccine operations and the trade receivables sales program, which are not available to Takeda's immediate or general business use. | \*2 Adjustment for cash temporarily held by Takeda on behalf of third parties refers to changes in cash balances that are temporarily held by Takeda on behalf of third parties related to vaccine operations and the trade receivables sales program, which are not available to Takeda's immediate or general business use. | \*2 Adjustment for cash temporarily held by Takeda on behalf of third parties refers to changes in cash balances that are temporarily held by Takeda on behalf of third parties related to vaccine operations and the trade receivables sales program, which are not available to Takeda's immediate or general business use. | \*2 Adjustment for cash temporarily held by Takeda on behalf of third parties refers to changes in cash balances that are temporarily held by Takeda on behalf of third parties related to vaccine operations and the trade receivables sales program, which are not available to Takeda's immediate or general business use. |
| \*3 Proceeds from sales of intangible assets are included in cash flow from operating activities, except certain immaterial transactions. | \*3 Proceeds from sales of intangible assets are included in cash flow from operating activities, except certain immaterial transactions. | \*3 Proceeds from sales of intangible assets are included in cash flow from operating activities, except certain immaterial transactions. | \*3 Proceeds from sales of intangible assets are included in cash flow from operating activities, except certain immaterial transactions. | \*3 Proceeds from sales of intangible assets are included in cash flow from operating activities, except certain immaterial transactions. | \*3 Proceeds from sales of intangible assets are included in cash flow from operating activities, except certain immaterial transactions. |

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![logo.jpg](logo.jpg)

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| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q1 Adjusted Net Debt to Adjusted EBITDA** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q1 Adjusted Net Debt to Adjusted EBITDA** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q1 Adjusted Net Debt to Adjusted EBITDA** | | | | |
| **ADJUSTED NET DEBT/ADJUSTED EBITDA RATIO** | | **NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS** | | | | |
| **(Billion JPY)** | **FY2025<br>Q1** | **(Billion JPY)** | **FY2024<br>Q1** | **FY2025<br>Q1** | **JPY Change** | **% Change** |
| Book value of bonds and loans on consolidated statement of financial position | (4505.9) | Net cash from operating activities (Operating Cash Flow) | 170.3 | 215.4 | 45.1 | 26.5% |
| Book value of bonds and loans on consolidated statement of financial position | (4505.9) | &nbsp;&nbsp;Acquisition of PP&E | (57.4) | (47.9) |  |  |
| Cash & cash equivalents | 350.0 | &nbsp;&nbsp;Proceeds from sales of PP&E | 0.0 | 6.4 |  |  |
| Net Debt<sup>\*1</sup> | (4155.9) | &nbsp;&nbsp;Acquisition of intangible assets | (80.4) | (27.2) |  |  |
| Application of equity credit<sup>\*2</sup> | 250.0 | &nbsp;&nbsp;Acquisition of option to license | (15.7) |  |  |  |
| FX adjustment<sup>\*3</sup> | (43.1) | &nbsp;&nbsp;Acquisition of investments | (13.0) | (0.2) |  |  |
| Cash temporarily held by Takeda on behalf of third parties<sup>\*4</sup> | (92.6) | &nbsp;&nbsp;Proceeds from sales and redemption of investments | 5.3 | 1.1 |  |  |
| Level 1 debt investments<sup>\*4</sup> | 76.7 | &nbsp;&nbsp;Proceeds from sales of business, net of cash and cash equivalents divested | 2.9 | 29.3 |  |  |
| Adjusted Net Debt<sup>\*1</sup> | (3965.0) | &nbsp;&nbsp;Payments for the settlement of forward exchange contracts designated as net investment hedges | (3.0) |  |  |  |
|  |  | &nbsp;&nbsp;Payments for the settlement of forward exchange contracts designated as net investment hedges | (3.0) |  |  |  |
| Adjusted EBITDA (LTM)<sup>\*5</sup> | 1372.4 | &nbsp;&nbsp;Net increase (decrease) in short-term loans and commercial papers | (17.0) | (46.0) |  |  |
|  |  | &nbsp;&nbsp;Proceeds from long-term loans | 50.0 |  |  |  |
| Adjusted Net Debt/Adjusted EBITDA ratio | 2.9x | &nbsp;&nbsp;Repayment of long-term loans | (50.1) | (10.0) |  |  |
|  |  | &nbsp;&nbsp;Proceeds from issuance of bonds | 457.6 | 183.6 |  |  |
| Book value of bonds and loans on consolidated statement of financial position | (4505.9) | &nbsp;&nbsp;Repayment of bonds |  | (115.3) |  |  |
| Book value of bonds and loans on consolidated statement of financial position | (4505.9) | &nbsp;&nbsp;Proceeds from the settlement of cross currency interest rate swaps related to bonds and loans | 46.9 |  |  |  |
| Application of equity credit<sup>\*2</sup> | 250.0 | &nbsp;&nbsp;Proceeds from the settlement of cross currency interest rate swaps related to bonds and loans | 46.9 |  |  |  |
| FX adjustment<sup>\*3</sup> | (43.1) | &nbsp;&nbsp;Acquisition of treasury shares | (1.9) | (51.6) |  |  |
| Adjusted Gross Debt | (4299.1) | &nbsp;&nbsp;Interest paid | (15.5) | (16.7) |  |  |
|  |  | &nbsp;&nbsp;Dividends paid | (138.1) | (145.3) |  |  |
|  |  | &nbsp;&nbsp;Others | (11.1) | (8.3) |  |  |
|  |  | Net increase (decrease) in cash and cash equivalents | 330.0 | (32.7) | (362.7) |  |
| \*1 Please refer to Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations for the definitions of Net Debt and Adjusted Net Debt. | \*1 Please refer to Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations for the definitions of Net Debt and Adjusted Net Debt. | \*1 Please refer to Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations for the definitions of Net Debt and Adjusted Net Debt. | \*1 Please refer to Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations for the definitions of Net Debt and Adjusted Net Debt. | \*1 Please refer to Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations for the definitions of Net Debt and Adjusted Net Debt. | \*1 Please refer to Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations for the definitions of Net Debt and Adjusted Net Debt. | \*1 Please refer to Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations for the definitions of Net Debt and Adjusted Net Debt. |
| \*2 Application of equity credit includes JPY 250.0 billion reduction in debt due to a 50% equity credit applied to JPY 500.0 billion principal amount of our hybrid (subordinated) bonds and loans by S&P Global Rating Japan, given that those instruments qualify for certain equity credit for leverage purposes. | \*2 Application of equity credit includes JPY 250.0 billion reduction in debt due to a 50% equity credit applied to JPY 500.0 billion principal amount of our hybrid (subordinated) bonds and loans by S&P Global Rating Japan, given that those instruments qualify for certain equity credit for leverage purposes. | \*2 Application of equity credit includes JPY 250.0 billion reduction in debt due to a 50% equity credit applied to JPY 500.0 billion principal amount of our hybrid (subordinated) bonds and loans by S&P Global Rating Japan, given that those instruments qualify for certain equity credit for leverage purposes. | \*2 Application of equity credit includes JPY 250.0 billion reduction in debt due to a 50% equity credit applied to JPY 500.0 billion principal amount of our hybrid (subordinated) bonds and loans by S&P Global Rating Japan, given that those instruments qualify for certain equity credit for leverage purposes. | \*2 Application of equity credit includes JPY 250.0 billion reduction in debt due to a 50% equity credit applied to JPY 500.0 billion principal amount of our hybrid (subordinated) bonds and loans by S&P Global Rating Japan, given that those instruments qualify for certain equity credit for leverage purposes. | \*2 Application of equity credit includes JPY 250.0 billion reduction in debt due to a 50% equity credit applied to JPY 500.0 billion principal amount of our hybrid (subordinated) bonds and loans by S&P Global Rating Japan, given that those instruments qualify for certain equity credit for leverage purposes. | \*2 Application of equity credit includes JPY 250.0 billion reduction in debt due to a 50% equity credit applied to JPY 500.0 billion principal amount of our hybrid (subordinated) bonds and loans by S&P Global Rating Japan, given that those instruments qualify for certain equity credit for leverage purposes. |
| \*3 FX adjustment refers to change from month-end rate to average rate used for non-JPY debt calculation outstanding at the beginning of the period to match with adjusted EBITDA (which is calculated based on average rates). New non-JPY debt incurred and existing non-JPY debt redeemed during the reporting period are translated to JPY at relevant spot rates as of the relevant date. | \*3 FX adjustment refers to change from month-end rate to average rate used for non-JPY debt calculation outstanding at the beginning of the period to match with adjusted EBITDA (which is calculated based on average rates). New non-JPY debt incurred and existing non-JPY debt redeemed during the reporting period are translated to JPY at relevant spot rates as of the relevant date. | \*3 FX adjustment refers to change from month-end rate to average rate used for non-JPY debt calculation outstanding at the beginning of the period to match with adjusted EBITDA (which is calculated based on average rates). New non-JPY debt incurred and existing non-JPY debt redeemed during the reporting period are translated to JPY at relevant spot rates as of the relevant date. | \*3 FX adjustment refers to change from month-end rate to average rate used for non-JPY debt calculation outstanding at the beginning of the period to match with adjusted EBITDA (which is calculated based on average rates). New non-JPY debt incurred and existing non-JPY debt redeemed during the reporting period are translated to JPY at relevant spot rates as of the relevant date. | \*3 FX adjustment refers to change from month-end rate to average rate used for non-JPY debt calculation outstanding at the beginning of the period to match with adjusted EBITDA (which is calculated based on average rates). New non-JPY debt incurred and existing non-JPY debt redeemed during the reporting period are translated to JPY at relevant spot rates as of the relevant date. | \*3 FX adjustment refers to change from month-end rate to average rate used for non-JPY debt calculation outstanding at the beginning of the period to match with adjusted EBITDA (which is calculated based on average rates). New non-JPY debt incurred and existing non-JPY debt redeemed during the reporting period are translated to JPY at relevant spot rates as of the relevant date. | \*3 FX adjustment refers to change from month-end rate to average rate used for non-JPY debt calculation outstanding at the beginning of the period to match with adjusted EBITDA (which is calculated based on average rates). New non-JPY debt incurred and existing non-JPY debt redeemed during the reporting period are translated to JPY at relevant spot rates as of the relevant date. |
| \*4 Adjustments related to cash temporarily held by Takeda on behalf of third parties related to vaccine operations and to the trade receivables sales program, which is not available to Takeda's immediate or general business use, and debt investments classified as Level 1 in the fair value hierarchy being recorded as Other Financial Assets. | \*4 Adjustments related to cash temporarily held by Takeda on behalf of third parties related to vaccine operations and to the trade receivables sales program, which is not available to Takeda's immediate or general business use, and debt investments classified as Level 1 in the fair value hierarchy being recorded as Other Financial Assets. | \*4 Adjustments related to cash temporarily held by Takeda on behalf of third parties related to vaccine operations and to the trade receivables sales program, which is not available to Takeda's immediate or general business use, and debt investments classified as Level 1 in the fair value hierarchy being recorded as Other Financial Assets. | \*4 Adjustments related to cash temporarily held by Takeda on behalf of third parties related to vaccine operations and to the trade receivables sales program, which is not available to Takeda's immediate or general business use, and debt investments classified as Level 1 in the fair value hierarchy being recorded as Other Financial Assets. | \*4 Adjustments related to cash temporarily held by Takeda on behalf of third parties related to vaccine operations and to the trade receivables sales program, which is not available to Takeda's immediate or general business use, and debt investments classified as Level 1 in the fair value hierarchy being recorded as Other Financial Assets. | \*4 Adjustments related to cash temporarily held by Takeda on behalf of third parties related to vaccine operations and to the trade receivables sales program, which is not available to Takeda's immediate or general business use, and debt investments classified as Level 1 in the fair value hierarchy being recorded as Other Financial Assets. | \*4 Adjustments related to cash temporarily held by Takeda on behalf of third parties related to vaccine operations and to the trade receivables sales program, which is not available to Takeda's immediate or general business use, and debt investments classified as Level 1 in the fair value hierarchy being recorded as Other Financial Assets. |
| \*5 LTM represents Last Twelve Months (July 2024 - June 2025). Calculated by subtracting FY2024 Q1 from FY2024 Full Year and adding FY2025 Q1. | \*5 LTM represents Last Twelve Months (July 2024 - June 2025). Calculated by subtracting FY2024 Q1 from FY2024 Full Year and adding FY2025 Q1. | \*5 LTM represents Last Twelve Months (July 2024 - June 2025). Calculated by subtracting FY2024 Q1 from FY2024 Full Year and adding FY2025 Q1. | \*5 LTM represents Last Twelve Months (July 2024 - June 2025). Calculated by subtracting FY2024 Q1 from FY2024 Full Year and adding FY2025 Q1. | \*5 LTM represents Last Twelve Months (July 2024 - June 2025). Calculated by subtracting FY2024 Q1 from FY2024 Full Year and adding FY2025 Q1. | \*5 LTM represents Last Twelve Months (July 2024 - June 2025). Calculated by subtracting FY2024 Q1 from FY2024 Full Year and adding FY2025 Q1. | \*5 LTM represents Last Twelve Months (July 2024 - June 2025). Calculated by subtracting FY2024 Q1 from FY2024 Full Year and adding FY2025 Q1. |

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![logo.jpg](logo.jpg)

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| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;&nbsp;&nbsp;**FY2024 Adjusted Net Debt to Adjusted EBITDA** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2024 Adjusted Net Debt to Adjusted EBITDA** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2024 Adjusted Net Debt to Adjusted EBITDA** | | | | |
| **ADJUSTED NET DEBT/ADJUSTED EBITDA RATIO** | | **NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS** | | | | |
| **(Billion JPY)** | **FY2024** | **(Billion JPY)** | **FY2023** | **FY2024** | **JPY Change** | **% Change** |
| Book value of bonds and loans on consolidated statement of financial position | (4515.3) | Net cash from operating activities (Operating Cash Flow) | 716.3 | 1057.2 | 340.8 | 47.6% |
| Book value of bonds and loans on consolidated statement of financial position | (4515.3) | &nbsp;&nbsp;Acquisition of PP&E | (175.4) | (200.8) |  |  |
| Cash & cash equivalents | 385.1 | &nbsp;&nbsp;Proceeds from sales of PP&E | 8.6 | 0.1 |  |  |
| Net Debt<sup>\*1</sup> | (4130.2) | &nbsp;&nbsp;Acquisition of intangible assets | (305.3) | (147.0) |  |  |
| Application of equity credit<sup>\*2</sup> | 250.0 | &nbsp;&nbsp;Acquisition of option to license |  | (31.8) |  |  |
| FX adjustment<sup>\*3</sup> | (68.9) | &nbsp;&nbsp;Acquisition of investments | (6.8) | (97.5) |  |  |
| Cash temporarily held by Takeda on behalf of third parties<sup>\*4</sup> | (105.8) | &nbsp;&nbsp;Proceeds from sales and redemption of investments | 8.0 | 29.4 |  |  |
| Level 1 debt investments<sup>\*4</sup> | 79.3 | &nbsp;&nbsp;Acquisition of shares in associates |  | (1.0) |  |  |
| Adjusted Net Debt<sup>\*1</sup> | (3975.5) | &nbsp;&nbsp;Proceeds from sales of shares in associates |  | 57.7 |  |  |
|  |  | &nbsp;&nbsp;Proceeds from sales of business, net of cash and cash equivalents divested | 20.0 | 20.6 |  |  |
| Adjusted EBITDA | 1441.0 | &nbsp;&nbsp;Payments for the settlement of forward exchange contracts designated as net investment hedges | (33.3) | (13.8) |  |  |
|  |  | &nbsp;&nbsp;Payments for the settlement of forward exchange contracts designated as net investment hedges | (33.3) | (13.8) |  |  |
| Adjusted Net Debt/Adjusted EBITDA ratio | 2.8x | &nbsp;&nbsp;Net increase (decrease) in short-term loans and commercial papers | 277.0 | 27.5 |  |  |
|  |  | &nbsp;&nbsp;Proceeds from long-term loans | 100.0 | 90.0 |  |  |
| Book value of bonds and loans on consolidated statement of financial position | (4515.3) | &nbsp;&nbsp;Repayment of long-term loans | (100.4) | (587.2) |  |  |
| Book value of bonds and loans on consolidated statement of financial position | (4515.3) | &nbsp;&nbsp;Proceeds from issuance of bonds |  | 934.5 |  |  |
| Application of equity credit<sup>\*2</sup> | 250.0 | &nbsp;&nbsp;Repayment of bonds | (220.5) | (733.8) |  |  |
| FX adjustment<sup>\*3</sup> | (68.9) | &nbsp;&nbsp;Proceeds from the settlement of cross currency interest rate swaps related to bonds and loans | 60.1 | 46.9 |  |  |
| Adjusted Gross Debt | (4334.2) | &nbsp;&nbsp;Proceeds from the settlement of cross currency interest rate swaps related to bonds and loans | 60.1 | 46.9 |  |  |
|  |  | &nbsp;&nbsp;Acquisition of treasury shares | (2.3) | (51.9) |  |  |
|  |  | &nbsp;&nbsp;Interest paid | (100.4) | (113.0) |  |  |
|  |  | &nbsp;&nbsp;Dividends paid | (287.2) | (302.5) |  |  |
|  |  | &nbsp;&nbsp;Others | (60.3) | (44.6) |  |  |
|  |  | Net increase (decrease) in cash and cash equivalents | (101.9) | (61.3) | 40.6 | 39.9% |
| \*1 Please refer to Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations for the definitions of Net Debt and Adjusted Net Debt. | \*1 Please refer to Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations for the definitions of Net Debt and Adjusted Net Debt. | \*1 Please refer to Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations for the definitions of Net Debt and Adjusted Net Debt. | \*1 Please refer to Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations for the definitions of Net Debt and Adjusted Net Debt. | \*1 Please refer to Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations for the definitions of Net Debt and Adjusted Net Debt. | \*1 Please refer to Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations for the definitions of Net Debt and Adjusted Net Debt. | \*1 Please refer to Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations for the definitions of Net Debt and Adjusted Net Debt. |
| \*2 Application of equity credit includes JPY 250.0 billion reduction in debt due to a 50% equity credit applied to JPY 500.0 billion principal amount of our hybrid (subordinated) bonds and loans by S&P Global Rating Japan, given that those instruments qualify for certain equity credit for leverage purposes. | \*2 Application of equity credit includes JPY 250.0 billion reduction in debt due to a 50% equity credit applied to JPY 500.0 billion principal amount of our hybrid (subordinated) bonds and loans by S&P Global Rating Japan, given that those instruments qualify for certain equity credit for leverage purposes. | \*2 Application of equity credit includes JPY 250.0 billion reduction in debt due to a 50% equity credit applied to JPY 500.0 billion principal amount of our hybrid (subordinated) bonds and loans by S&P Global Rating Japan, given that those instruments qualify for certain equity credit for leverage purposes. | \*2 Application of equity credit includes JPY 250.0 billion reduction in debt due to a 50% equity credit applied to JPY 500.0 billion principal amount of our hybrid (subordinated) bonds and loans by S&P Global Rating Japan, given that those instruments qualify for certain equity credit for leverage purposes. | \*2 Application of equity credit includes JPY 250.0 billion reduction in debt due to a 50% equity credit applied to JPY 500.0 billion principal amount of our hybrid (subordinated) bonds and loans by S&P Global Rating Japan, given that those instruments qualify for certain equity credit for leverage purposes. | \*2 Application of equity credit includes JPY 250.0 billion reduction in debt due to a 50% equity credit applied to JPY 500.0 billion principal amount of our hybrid (subordinated) bonds and loans by S&P Global Rating Japan, given that those instruments qualify for certain equity credit for leverage purposes. | \*2 Application of equity credit includes JPY 250.0 billion reduction in debt due to a 50% equity credit applied to JPY 500.0 billion principal amount of our hybrid (subordinated) bonds and loans by S&P Global Rating Japan, given that those instruments qualify for certain equity credit for leverage purposes. |
| \*3 FX adjustment refers to change from month-end rate to average rate used for non-JPY debt calculation outstanding at the beginning of the period to match with adjusted EBITDA (which is calculated based on average rates). New non-JPY debt incurred and existing non-JPY debt redeemed during the reporting period are translated to JPY at relevant spot rates as of the relevant date. | \*3 FX adjustment refers to change from month-end rate to average rate used for non-JPY debt calculation outstanding at the beginning of the period to match with adjusted EBITDA (which is calculated based on average rates). New non-JPY debt incurred and existing non-JPY debt redeemed during the reporting period are translated to JPY at relevant spot rates as of the relevant date. | \*3 FX adjustment refers to change from month-end rate to average rate used for non-JPY debt calculation outstanding at the beginning of the period to match with adjusted EBITDA (which is calculated based on average rates). New non-JPY debt incurred and existing non-JPY debt redeemed during the reporting period are translated to JPY at relevant spot rates as of the relevant date. | \*3 FX adjustment refers to change from month-end rate to average rate used for non-JPY debt calculation outstanding at the beginning of the period to match with adjusted EBITDA (which is calculated based on average rates). New non-JPY debt incurred and existing non-JPY debt redeemed during the reporting period are translated to JPY at relevant spot rates as of the relevant date. | \*3 FX adjustment refers to change from month-end rate to average rate used for non-JPY debt calculation outstanding at the beginning of the period to match with adjusted EBITDA (which is calculated based on average rates). New non-JPY debt incurred and existing non-JPY debt redeemed during the reporting period are translated to JPY at relevant spot rates as of the relevant date. | \*3 FX adjustment refers to change from month-end rate to average rate used for non-JPY debt calculation outstanding at the beginning of the period to match with adjusted EBITDA (which is calculated based on average rates). New non-JPY debt incurred and existing non-JPY debt redeemed during the reporting period are translated to JPY at relevant spot rates as of the relevant date. | \*3 FX adjustment refers to change from month-end rate to average rate used for non-JPY debt calculation outstanding at the beginning of the period to match with adjusted EBITDA (which is calculated based on average rates). New non-JPY debt incurred and existing non-JPY debt redeemed during the reporting period are translated to JPY at relevant spot rates as of the relevant date. |
| \*4 Adjustments related to cash temporarily held by Takeda on behalf of third parties related to vaccine operations and to the trade receivables sales program, which is not available to Takeda's immediate or general business use, and debt investments classified as Level 1 in the fair value hierarchy being recorded as Other Financial Assets. | \*4 Adjustments related to cash temporarily held by Takeda on behalf of third parties related to vaccine operations and to the trade receivables sales program, which is not available to Takeda's immediate or general business use, and debt investments classified as Level 1 in the fair value hierarchy being recorded as Other Financial Assets. | \*4 Adjustments related to cash temporarily held by Takeda on behalf of third parties related to vaccine operations and to the trade receivables sales program, which is not available to Takeda's immediate or general business use, and debt investments classified as Level 1 in the fair value hierarchy being recorded as Other Financial Assets. | \*4 Adjustments related to cash temporarily held by Takeda on behalf of third parties related to vaccine operations and to the trade receivables sales program, which is not available to Takeda's immediate or general business use, and debt investments classified as Level 1 in the fair value hierarchy being recorded as Other Financial Assets. | \*4 Adjustments related to cash temporarily held by Takeda on behalf of third parties related to vaccine operations and to the trade receivables sales program, which is not available to Takeda's immediate or general business use, and debt investments classified as Level 1 in the fair value hierarchy being recorded as Other Financial Assets. | \*4 Adjustments related to cash temporarily held by Takeda on behalf of third parties related to vaccine operations and to the trade receivables sales program, which is not available to Takeda's immediate or general business use, and debt investments classified as Level 1 in the fair value hierarchy being recorded as Other Financial Assets. | \*4 Adjustments related to cash temporarily held by Takeda on behalf of third parties related to vaccine operations and to the trade receivables sales program, which is not available to Takeda's immediate or general business use, and debt investments classified as Level 1 in the fair value hierarchy being recorded as Other Financial Assets. |

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| | | | | |
|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q1 Net Profit to Adjusted EBITDA Bridge** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q1 Net Profit to Adjusted EBITDA Bridge** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q1 Net Profit to Adjusted EBITDA Bridge** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q1 Net Profit to Adjusted EBITDA Bridge** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q1 Net Profit to Adjusted EBITDA Bridge** |
| **(Billion JPY)** | **FY2024<br>Q1** | **FY2025<br>Q1** | **JPY Change** | **% Change** |
| Net profit | 95.3 | 124.3 | 29.0 | 30.4% |
| &nbsp;&nbsp;Income tax expenses (benefit) | 41.3 | 26.4 |  |  |
| &nbsp;&nbsp;Depreciation and amortization | 192.2 | 181.6 |  |  |
| &nbsp;&nbsp;Interest expense, net | 26.6 | 29.2 |  |  |
| EBITDA | 355.4 | 361.5 | 6.0 | 1.7% |
| &nbsp;&nbsp;Impairment losses | 26.0 | 2.4 |  |  |
| &nbsp;&nbsp;Other operating expense (income), net, excluding depreciation and amortization and impairment losses | 50.7 | 4.3 |  |  |
| &nbsp;&nbsp;Finance expense (income), net, excluding interest expense, net | 2.4 | 4.2 |  |  |
| &nbsp;&nbsp;Share of loss (profit) of investments accounted for using the equity method | 0.7 | 0.5 |  |  |
| &nbsp;&nbsp;Other costs<sup>\*1</sup> | 14.9 | 15.7 |  |  |
| Adjusted EBITDA | 450.1 | 388.6 | (61.5) | (13.7)% |
| \*1 Includes adjustments for non-cash equity-based compensation expense and other one time non-cash expense. | \*1 Includes adjustments for non-cash equity-based compensation expense and other one time non-cash expense. | \*1 Includes adjustments for non-cash equity-based compensation expense and other one time non-cash expense. | \*1 Includes adjustments for non-cash equity-based compensation expense and other one time non-cash expense. | \*1 Includes adjustments for non-cash equity-based compensation expense and other one time non-cash expense. |

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| | | | | |
|:---|:---|:---|:---|:---|
| &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q1 Net Profit to Adjusted EBITDA LTM Bridge** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q1 Net Profit to Adjusted EBITDA LTM Bridge** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q1 Net Profit to Adjusted EBITDA LTM Bridge** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q1 Net Profit to Adjusted EBITDA LTM Bridge** | &nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q1 Net Profit to Adjusted EBITDA LTM Bridge** |
| **(Billion JPY)** | **FY2024<br>Full Year<br>(Apr - Mar)** | **FY2024<br>Q1<br>(Apr - Jun)** | **FY2025<br>Q1<br>(Apr - Jun)** | **FY2025**<br>**Q1 LTM**<sup>\*1</sup><br>**(Jul - Jun)** |
| Net profit | 108.1 | 95.3 | 124.3 | 137.1 |
| &nbsp;&nbsp;Income tax expenses (benefit) | 66.9 | 41.3 | 26.4 | 52.0 |
| &nbsp;&nbsp;Depreciation and amortization | 761.4 | 192.2 | 181.6 | 750.8 |
| &nbsp;&nbsp;Interest expense, net | 117.7 | 26.6 | 29.2 | 120.3 |
| EBITDA | 1054.2 | 355.4 | 361.5 | 1060.2 |
| &nbsp;&nbsp;Impairment losses | 106.5 | 26.0 | 2.4 | 82.9 |
| &nbsp;&nbsp;Other operating expense (income), net, excluding depreciation and amortization and impairment losses | 163.2 | 50.7 | 4.3 | 116.8 |
| &nbsp;&nbsp;Finance expense (income), net, excluding interest expense, net | 45.8 | 2.4 | 4.2 | 47.6 |
| &nbsp;&nbsp;Share of loss (profit) of investments accounted for using the equity method | 4.0 | 0.7 | 0.5 | 3.8 |
| &nbsp;&nbsp;Other costs<sup>\*2</sup> | 67.4 | 14.9 | 15.7 | 68.3 |
| Adjusted EBITDA | 1441.2 | 450.1 | 388.6 | 1379.7 |
| &nbsp;&nbsp;EBITDA from divested products<sup>\*3</sup> | (0.2) |  |  | (7.2) |
| Adjusted EBITDA (LTM) | 1441.0 |  |  | 1372.4 |
| \*1 LTM represents Last Twelve Months (July 2024 - June 2025). Calculated by subtracting FY2024 Q1 from FY2024 Full Year and adding FY2025 Q1. | \*1 LTM represents Last Twelve Months (July 2024 - June 2025). Calculated by subtracting FY2024 Q1 from FY2024 Full Year and adding FY2025 Q1. | \*1 LTM represents Last Twelve Months (July 2024 - June 2025). Calculated by subtracting FY2024 Q1 from FY2024 Full Year and adding FY2025 Q1. | \*1 LTM represents Last Twelve Months (July 2024 - June 2025). Calculated by subtracting FY2024 Q1 from FY2024 Full Year and adding FY2025 Q1. | \*1 LTM represents Last Twelve Months (July 2024 - June 2025). Calculated by subtracting FY2024 Q1 from FY2024 Full Year and adding FY2025 Q1. |
| \*2 Includes adjustments for non-cash equity-based compensation expense and other one time non-cash expense. | \*2 Includes adjustments for non-cash equity-based compensation expense and other one time non-cash expense. | \*2 Includes adjustments for non-cash equity-based compensation expense and other one time non-cash expense. | \*2 Includes adjustments for non-cash equity-based compensation expense and other one time non-cash expense. | \*2 Includes adjustments for non-cash equity-based compensation expense and other one time non-cash expense. |
| \*3 Represents adjustments for EBITDA from divested products which are removed as part of LTM Adjusted EBITDA. | \*3 Represents adjustments for EBITDA from divested products which are removed as part of LTM Adjusted EBITDA. | \*3 Represents adjustments for EBITDA from divested products which are removed as part of LTM Adjusted EBITDA. | \*3 Represents adjustments for EBITDA from divested products which are removed as part of LTM Adjusted EBITDA. | \*3 Represents adjustments for EBITDA from divested products which are removed as part of LTM Adjusted EBITDA. |

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&nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Q1 CAPEX, Depreciation and Amortization and Impairment Losses**<br>

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| | | | | | |
|:---|:---|:---|:---|:---|:---|
| **(Billion JPY)** | **FY2024 Q1** | **FY2025 Q1** | **JPY Change** | **% Change** | **FY2025 Forecast** |
| Capital expenditures<sup>\*1</sup> | 137.8 | 75.1 | (62.7) | (45.5)% | 270.0 - 320.0 |
| &nbsp;&nbsp;Tangible assets | 57.4 | 47.9 | (9.5) | (16.6)% |  |
| &nbsp;&nbsp;Intangible assets | 80.4 | 27.2 | (53.2) | (66.2)% |  |
| Depreciation and amortization | 192.2 | 181.6 | (10.6) | (5.5)% | 716.0 |
| &nbsp;&nbsp;Depreciation of tangible assets<sup>\*2</sup> (A) | 43.9 | 42.6 | (1.4) | (3.1)% |  |
| &nbsp;&nbsp;Amortization of intangible assets (B) | 148.3 | 139.1 | (9.2) | (6.2)% |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Of which Amortization on intangible assets associated with products (C) | 138.6 | 129.3 | (9.3) | (6.7)% | 500.0 |
| &nbsp;&nbsp;&nbsp;&nbsp;Of which Amortization excluding intangible assets <br>&nbsp;&nbsp;&nbsp;&nbsp;associated with products (D) | 9.7 | 9.7 | 0.1 | 0.5% |  |
| Depreciation and amortization (excluding<br> intangible assets associated with products) (A)+(D) | 53.6 | 52.3 | (1.3) | (2.4)% | 216.0 |
| Impairment losses | 26.0 | 2.4 | (23.6) | (90.9)% |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Impairment losses on intangible assets associated with products<sup>\*3</sup> | 24.2 | 2.3 | (21.9) | (90.5)% | 50.0 |
| Amortization and impairment losses on intangible assets associated with products | 162.8 | 131.6 | (31.2) | (19.2)% | 550.0 |
| \*1 Cash flow base |  |  |  |  |  |
| \*2 Includes depreciation of investment properties | \*2 Includes depreciation of investment properties | \*2 Includes depreciation of investment properties | \*2 Includes depreciation of investment properties | \*2 Includes depreciation of investment properties | \*2 Includes depreciation of investment properties |
| \*3 Includes in-process R&D |  |  |  |  |  |

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&nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Full Year Detailed Forecast**<br>

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| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| **(BN JPY)** | **(BN JPY)** | **FY2024<br>Actual** | **FY2025 Forecast<br>(May 8, 2025)** | **JPY Change** | **% Change** | **Variances** |
| **(BN JPY)** | **(BN JPY)** | **FY2024<br>Actual** | **FY2025 Forecast<br>(May 8, 2025)** | **JPY Change** | **% Change** | **Variances** |
| **REPORTED** | Revenue | 4581.6 | 4530.0 | (51.6) | (1.1)% | LOE impact (mainly VYVANSE), pricing and FX headwinds, partially offset by Growth & Launch Products |
| **REPORTED** | &nbsp;&nbsp;&nbsp;Cost of sales | (1580.2) | (1540.0) | 40.2 | 2.5% |  |
| **REPORTED** | Gross Profit | 3001.3 | 2990.0 | (11.3) | (0.4)% | Less impact from implementation of accounting process to recognize accumulated FX impact of inventories |
| **REPORTED** | &nbsp;&nbsp;&nbsp;SG&A expenses | (1104.8) | (1100.0) | 4.8 | 0.4% | Savings from the Efficiency Program and FX benefits partially offset by investments in DD&T and new launches |
| **REPORTED** | &nbsp;&nbsp;&nbsp;R&D expenses | (730.2) | (750.0) | (19.8) | (2.7)% | Ramp-up of trial costs offset by the Efficiency Program and FX benefits |
| **REPORTED** | &nbsp;&nbsp;&nbsp;Amortization of intangible assets associated with products | (548.2) | (500.0) | 48.2 | 8.8% | Conclusion of amortization of several products, including VYVANSE (in January FY25) |
| **REPORTED** | &nbsp;&nbsp;Impairment losses on intangible assets associated with products<sup>\*1</sup> | (95.0) | (50.0) | 45.0 | 47.4% |  |
| **REPORTED** | &nbsp;&nbsp;&nbsp;Other operating income | 26.2 | 10.0 | (16.2) | (61.9)% | Reduction of divestiture gains (FY24 TACHOSIL manufacturing site) and others |
| **REPORTED** | &nbsp;&nbsp;&nbsp;Other operating expenses | (206.7) | (125.0) | 81.7 | 39.5% | Primarily reflects lower restructuring expenses projected in FY25 (FY24 actual: 128.1 B vs. FY25 forecast: 48.0 B) |
| **REPORTED** | Operating profit | 342.6 | 475.0 | 132.4 | 38.7% |  |
| **REPORTED** | &nbsp;&nbsp;&nbsp;Finance income (expenses), net | (163.5) | (167.0) | (3.5) | (2.1)% |  |
| **REPORTED** | Profit before tax | 175.1 | 307.0 | 131.9 | 75.3% |  |
| **REPORTED** | Net profit attributable to owners of the Company | 107.9 | 228.0 | 120.1 | 111.3% | Mainly driven by increase of profit before tax partially offset by lower derecognition of tax loss carry forward |
| **REPORTED** | Basic EPS (yen) | 68 | 145 | 76 | 111.8% |  |
|  | Core Revenue<sup>\*2</sup> | 4579.8 | 4530.0 | (49.8) | (1.1)% | LOE impact (mainly VYVANSE), pricing and FX headwinds, partially offset by Growth & Launch Products |
|  | Core Operating Profit<sup>\*2</sup> | 1162.6 | 1140.0 | (22.6) | (1.9)% | Maily due to FX headwinds |
|  | Core EPS (yen)<sup>\*2</sup> | 491 | 485 | (6) | (1.2)% |  |
|  | Adjusted Free Cash Flow<sup>\*2</sup> | 769.0 | 750.0 to 850.0 |  |  | While Core OP is flat FY 24 vs. FY 25, we expect higher FCF in FY 25 mainly due to lower restructuring spend in FY 25 |
|  | CAPEX (cash flow base) | (347.8) | (270.0) to (320.0) |  |  |  |
|  | Depreciation and amortization (excl. intangible assets associated with products) | (213.2) | (216.0) | (2.8) | (1.3)% |  |
|  | Cash tax rate on Adjusted EBITDA (excl. divestitures)<sup>\*2</sup> | Approx.10% | Mid teen% |  |  |  |
|  | USD/JPY | 152 | 150 | (2) | (1.6)% |  |
|  | EUR/JPY | 163 | 160 | (3) | (2.1)% |  |

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\*1 Includes in-process R&D.<br>\*2 Please refer to *Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations*, for the definition of Non-IFRS Measures and FY2025 Full Year Reconciliation from Reported Operating Profit to Core Operating Profit Forecast.

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&nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Full Year Reconciliation from Reported Operating Profit to Core Operating Profit Forecast**<br>

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| | | | | | |
|:---|:---|:---|:---|:---|:---|
| **(Billion JPY)** | **Reported** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Reported to Core adjustments** | **Core** |
| **(Billion JPY)** | **Reported** | Amortization of<br>intangible<br>assets | Impairment of<br>intangible<br>assets | Other operating income (expenses) | **Core** |
| Revenue | 4530.0 |  |  |  | 4530.0 |
| &nbsp;&nbsp;Cost of sales | (1540.0) |  |  |  | (3390.0) |
| Gross Profit | 2990.0 |  |  |  | (3390.0) |
| &nbsp;&nbsp;SG&A expenses | (1100.0) |  |  |  | (3390.0) |
| &nbsp;&nbsp;R&D expenses | (750.0) |  |  |  | (3390.0) |
| &nbsp;&nbsp;Amortization of intangible assets associated with products | (500.0) | 500.0 |  |  |  |
| &nbsp;&nbsp;Impairment losses on intangible assets associated with products<sup>\*1</sup> | (50.0) |  | 50.0 |  |  |
| &nbsp;&nbsp;Other operating income | 10.0 |  |  | (10.0) |  |
| &nbsp;&nbsp;Other operating expenses | (125.0) |  |  | 125.0 |  |
| Operating profit | 475.0 | 500.0 | 50.0 | 115.0 | 1140.0 |

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\*1 Includes in-process R&D

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&nbsp;&nbsp;&nbsp;&nbsp;**FY2025 Full Year FX Rates Assumptions and Currency Sensitivity vs. Forecast**<br>

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| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| **Average Exchange Rates vs. JPY** | **Average Exchange Rates vs. JPY** | **Average Exchange Rates vs. JPY** | **Average Exchange Rates vs. JPY** | **Impact of depreciation of yen from April 2025 to March 2026 (100 million JPY)** | **Impact of depreciation of yen from April 2025 to March 2026 (100 million JPY)** | **Impact of depreciation of yen from April 2025 to March 2026 (100 million JPY)** | **Impact of depreciation of yen from April 2025 to March 2026 (100 million JPY)** | **Impact of depreciation of yen from April 2025 to March 2026 (100 million JPY)** |
| | **FY2024<br>Actual<br>(Apr-Jun)** | **FY2025<br>Actual<br>(Apr-Jun)** | **FY2025 Full Year<br>Assumption<br>(Apr-Mar)** | | **Revenue<br>(IFRS)** | **Operating<br>Profit<br>(IFRS)** | **Net Profit<br>(IFRS)** | **Core<br>Operating<br>Profit<br>(non-IFRS)** |
| **USD** | 155 | 145 | 150 | 1% depreciation | 234.3 | 8.3 | (1.1) | 52.5 |
| **USD** | 155 | 145 | 150 | 1 yen depreciation | 156.2 | 5.5 | (0.7) | 35.0 |
| **EUR** | 167 | 162 | 160 | 1% depreciation | 65.6 | (28.2) | (25.0) | (17.1) |
| **EUR** | 167 | 162 | 160 | 1 yen depreciation | 41.0 | (17.6) | (15.7) | (10.7) |
| **RUB** | 1.7 | 1.8 | 1.7 | 1% depreciation | 5.6 | 3.3 | 2.5 | 3.8 |
| **CNY** | 21.4 | 20.1 | 20.5 | 1% depreciation | 19.5 | 11.8 | 8.9 | 11.9 |
| **BRL** | 30.4 | 25.6 | 25.9 | 1% depreciation | 12.9 | 9.7 | 6.4 | 9.8 |

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**Important Notice**

For the purposes of this notice, "report" means this document, any oral presentation, any question and answer session and any written or oral material discussed or distributed by Takeda Pharmaceutical Company Limited ("Takeda") regarding this report. This report (including any oral briefing and any question-and-answer in connection with it) is not intended to, and does not constitute, represent or form part of any offer, invitation or solicitation of any offer to purchase, otherwise acquire, subscribe for, exchange, sell or otherwise dispose of, any securities or the solicitation of any vote or approval in any jurisdiction. No shares or other securities are being offered to the public by means of this report. No offering of securities shall be made in the United States except pursuant to registration under the U.S. Securities Act of 1933, as amended, or an exemption therefrom. This report is being given (together with any further information which may be provided to the recipient) on the condition that it is for use by the recipient for information purposes only (and not for the evaluation of any investment, acquisition, disposal or any other transaction). Any failure to comply with these restrictions may constitute a violation of applicable securities laws.

The companies in which Takeda directly and indirectly owns investments are separate entities. In this report, "Takeda" is sometimes used for convenience where references are made to Takeda and its subsidiaries in general. Likewise, the words "we", "us" and "our" are also used to refer to subsidiaries in general or to those who work for them. These expressions are also used where no useful purpose is served by identifying the particular company or companies.

The product names appearing in this document are trademarks or registered trademarks owned by Takeda, or their respective owners.

**Forward-Looking Statements**

This report and any materials distributed in connection with this report may contain forward-looking statements, beliefs or opinions regarding Takeda's future business, future position and results of operations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking statements often include words such as "targets", "plans", "believes", "hopes", "continues", "expects", "aims", "intends", "ensures", "will", "may", "should", "would", "could", "anticipates", "estimates", "projects", "forecasts", "outlook" or similar expressions or the negative thereof. These forward-looking statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those expressed or implied by the forward-looking statements: the economic circumstances surrounding Takeda's global business, including general economic conditions in Japan and the United States and with respect to international trade relations; competitive pressures and developments; changes to applicable laws and regulations, including tax, tariff and other trade-related rules; challenges inherent in new product development, including uncertainty of clinical success and decisions of regulatory authorities and the timing thereof; uncertainty of commercial success for new and existing products; manufacturing difficulties or delays; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the impact of health crises, like the novel coronavirus pandemic; the success of our environmental sustainability efforts, in enabling us to reduce our greenhouse gas emissions or meet our other environmental goals; the extent to which our efforts to increase efficiency, productivity or cost-savings, such as the integration of digital technologies, including artificial intelligence, in our business or other initiatives to restructure our operations will lead to the expected benefits; and other factors identified in Takeda's most recent Annual Report on Form 20-F and Takeda's other reports filed with the U.S. Securities and Exchange Commission, available on Takeda's website at: https://www.takeda.com/investors/sec-filings-and-security-reports/ or at www.sec.gov. Takeda does not undertake to update any of the forward-looking statements contained in this report or any other forward-looking statements it may make, except as required by law or stock exchange rule. Past performance is not an indicator of future results and the results or statements of Takeda in this report may not be indicative of, and are not an estimate, forecast, guarantee or projection of Takeda's future results.

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**Financial Information and Non-IFRS Measures**

Takeda's financial statements are prepared in accordance with International Financial Reporting Standards ("IFRS").

This report and materials distributed in connection with this report include certain financial measures not presented in accordance with IFRS, such as Core Revenue, Core Operating Profit, Core Net Profit for the year attributable to owners of the Company, Core EPS, Constant Exchange Rate ("CER") change, Net Debt, Adjusted Net Debt, EBITDA, Adjusted EBITDA, Free Cash Flow and Adjusted Free Cash Flow. Takeda's management evaluates results and makes operating and investment decisions using both IFRS and non-IFRS measures included in this presentation. These non-IFRS measures exclude certain income, cost and cash flow items which are included in, or are calculated differently from, the most closely comparable measures presented in accordance with IFRS. Takeda's non-IFRS measures are not prepared in accordance with IFRS and such non-IFRS measures should be considered a supplement to, and not a substitute for, measures prepared in accordance with IFRS (which we sometimes refer to as "reported" measures). Investors are encouraged to review the definitions and reconciliations of non-IFRS measures to their most directly comparable IFRS measures.

The usefulness of Core Financial Measures to investors has significant limitations including, but not limited to, (i) they are not necessarily identical to similarly titled measures used by other companies, including those in the pharmaceutical industry, (ii) they exclude financial information and events, such as the effects of non-cash expenses such as dispositions or amortization of intangible assets, that some may consider important in evaluating Takeda's performance, value or prospects for the future, (iii) they exclude items or types of items that may continue to occur from period to period in the future (however, it is Takeda's policy not to adjust out normal, recurring cash operating expenses necessary to operate our business) and (iv) they may not include all items which investors may consider important to an understanding of our results of operations, or exclude all items which investors may not consider to be so.

**Medical Information**

This report contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs including the ones under development.