# EDGAR Filing Document

**Accession Number:** 0001689548
**File Stem:** 0001193125-23-067238
**Filing Date:** 2023-3
**Character Count:** 18642
**Document Hash:** 2f350123c0b9ad3ac47f097982bd57e4
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-23-067238.hdr.sgml**: 20230310

**ACCESSION NUMBER**: 0001193125-23-067238

**CONFORMED SUBMISSION TYPE**: SC 13G

**PUBLIC DOCUMENT COUNT**: 2

**FILED AS OF DATE**: 20230310

**DATE AS OF CHANGE**: 20230310

**GROUP MEMBERS**: PANACEA INNOVATION LTD

**GROUP MEMBERS**: PANACEA OPPORTUNITY FUND I GP COMPANY, LTD.

**GROUP MEMBERS**: PANACEA OPPORTUNITY FUND I, L.P.

**SUBJECT COMPANY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Praxis Precision Medicines, Inc.
- **CENTRAL INDEX KEY:** 0001689548
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **IRS NUMBER:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** SC 13G
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 005-92098
- **FILM NUMBER:** 23722645

**BUSINESS ADDRESS:**
- **STREET 1:** 99 HIGH STREET, 30TH FLOOR
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02110
- **BUSINESS PHONE:** 617-300-8460

**MAIL ADDRESS:**
- **STREET 1:** 99 HIGH STREET, 30TH FLOOR
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02110
**FILED BY**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Huang James
- **CENTRAL INDEX KEY:** 0001573160

**FILING VALUES:**
- **FORM TYPE:** SC 13G

**MAIL ADDRESS:**
- **STREET 1:** 9620 MEDICAL CENTER DRIVE
- **STREET 2:** SUITE 300
- **CITY:** ROCKVILLE
- **STATE:** MD
- **ZIP:** 20850

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**Securities and Exchange Commission** 

**Washington, D.C. 20549** 

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**Schedule 13G** 

**(Rule 13d-102)** 

**Information to be Included in Statements Filed Pursuant** 

**to § 240.13d-1(b), (c) and (d) and Amendments Thereto Filed** 

**Pursuant to § 240.13d-2** 

**UNDER THE SECURITIES EXCHANGE ACT OF 1934** 

**(Amendment No.)\*** 

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## Praxis Precision Medicines, Inc.
**(Name of Issuer)** 

**Common Stock** 

**(Title of Class of Securities)** 

**74006W108** 

**(CUSIP Number)** 

**March 9, 2023** 

**(Date of Event Which Requires Filing of this Statement)** 

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Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

☐ Rule 13d-1(b)

☒ Rule 13d-1(c)

☐ Rule 13d-1(d)

\* The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

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CUSIP No. 74006W108 Schedule 13G Page 1 of 9

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| | |
|:---|:---|
| &nbsp;&nbsp;&nbsp; 1 | &nbsp;&nbsp;&nbsp;&nbsp;Names of Reporting Persons<br>&nbsp;&nbsp;&nbsp;&nbsp;**Panacea Opportunity Fund I, L.P.** |
| &nbsp;&nbsp;&nbsp; 2 | &nbsp;&nbsp;&nbsp;&nbsp;Check the Appropriate Box if a Member of a Group<br> &nbsp;&nbsp;&nbsp;&nbsp;(a) ☐ (b) ☐ |
| &nbsp;&nbsp;&nbsp; 3 | &nbsp;&nbsp;&nbsp;&nbsp;SEC Use Only |
| &nbsp;&nbsp;&nbsp; 4 | &nbsp;&nbsp;&nbsp;&nbsp;Citizenship or Place of Organization<br>&nbsp;&nbsp;&nbsp;&nbsp;**Cayman Islands** |

---

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 5 | &nbsp;&nbsp;&nbsp;&nbsp;Sole Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;**0** |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 6 | &nbsp;&nbsp;&nbsp;&nbsp;Shared Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;**2,650,000** |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 7 | &nbsp;&nbsp;&nbsp;&nbsp;Sole Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;**0** |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 8 | &nbsp;&nbsp;&nbsp;&nbsp;Shared Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;**2,650,000** |

---

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| | |
|:---|:---|
| &nbsp;&nbsp;&nbsp; 9 | &nbsp;&nbsp;&nbsp;&nbsp;Aggregate Amount Beneficially Owned by Each Reporting Person<br>&nbsp;&nbsp;&nbsp;&nbsp;**2,650,000** |
| &nbsp;&nbsp;&nbsp;10 | &nbsp;&nbsp;&nbsp;&nbsp;Check if the Aggregate Amount in Row (9) Excludes Certain Shares<br>&nbsp;&nbsp;&nbsp;&nbsp;**Not Applicable** |
| &nbsp;&nbsp;&nbsp;11 | &nbsp;&nbsp;&nbsp;&nbsp;Percent of Class Represented by Amount in Row 9<br>&nbsp;&nbsp;&nbsp;&nbsp;**5.1%** |
| &nbsp;&nbsp;&nbsp;12 | &nbsp;&nbsp;&nbsp;&nbsp;Type of Reporting Person<br>&nbsp;&nbsp;&nbsp;&nbsp;**PN** |

---

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CUSIP No. 74006W108 Schedule 13G Page 2 of 9

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| | |
|:---|:---|
| &nbsp;&nbsp;&nbsp; 1 | &nbsp;&nbsp;&nbsp;&nbsp;Names of Reporting Persons<br>&nbsp;&nbsp;&nbsp;&nbsp;**Panacea Opportunity Fund I GP Company, Ltd.**  |
| &nbsp;&nbsp;&nbsp; 2 | &nbsp;&nbsp;&nbsp;&nbsp;Check the Appropriate Box if a Member of a Group<br> &nbsp;&nbsp;&nbsp;&nbsp;(a) ☐ (b) ☐ |
| &nbsp;&nbsp;&nbsp; 3 | &nbsp;&nbsp;&nbsp;&nbsp;SEC Use Only |
| &nbsp;&nbsp;&nbsp; 4 | &nbsp;&nbsp;&nbsp;&nbsp;Citizenship or Place of Organization<br>&nbsp;&nbsp;&nbsp;&nbsp;**Cayman Islands** |

---

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 5 | &nbsp;&nbsp;&nbsp;&nbsp;Sole Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;**0** |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 6 | &nbsp;&nbsp;&nbsp;&nbsp;Shared Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;**2,650,000** |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 7 | &nbsp;&nbsp;&nbsp;&nbsp;Sole Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;**0** |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 8 | &nbsp;&nbsp;&nbsp;&nbsp;Shared Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;**2,650,000** |

---

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| | |
|:---|:---|
| &nbsp;&nbsp;&nbsp; 9 | &nbsp;&nbsp;&nbsp;&nbsp;Aggregate Amount Beneficially Owned by Each Reporting Person<br>&nbsp;&nbsp;&nbsp;&nbsp;**2,650,000** |
| &nbsp;&nbsp;&nbsp;10 | &nbsp;&nbsp;&nbsp;&nbsp;Check if the Aggregate Amount in Row (9) Excludes Certain Shares<br>&nbsp;&nbsp;&nbsp;&nbsp;**Not Applicable** |
| &nbsp;&nbsp;&nbsp;11 | &nbsp;&nbsp;&nbsp;&nbsp;Percent of Class Represented by Amount in Row 9<br>&nbsp;&nbsp;&nbsp;&nbsp;**5.1%** |
| &nbsp;&nbsp;&nbsp;12 | &nbsp;&nbsp;&nbsp;&nbsp;Type of Reporting Person<br>&nbsp;&nbsp;&nbsp;&nbsp;**CO** |

---

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CUSIP No. 74006W108 Schedule 13G Page 3 of 9

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| | |
|:---|:---|
| &nbsp;&nbsp;&nbsp; 1 | &nbsp;&nbsp;&nbsp;&nbsp;Names of Reporting Persons<br>&nbsp;&nbsp;&nbsp;&nbsp;**Panacea Innovation Limited**  |
| &nbsp;&nbsp;&nbsp; 2 | &nbsp;&nbsp;&nbsp;&nbsp;Check the Appropriate Box if a Member of a Group<br> &nbsp;&nbsp;&nbsp;&nbsp;(a) ☐ (b) ☐ |
| &nbsp;&nbsp;&nbsp; 3 | &nbsp;&nbsp;&nbsp;&nbsp;SEC Use Only |
| &nbsp;&nbsp;&nbsp; 4 | &nbsp;&nbsp;&nbsp;&nbsp;Citizenship or Place of Organization<br>&nbsp;&nbsp;&nbsp;&nbsp;**Cayman Islands** |

---

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| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 5 | &nbsp;&nbsp;&nbsp;&nbsp;Sole Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;**0** |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 6 | &nbsp;&nbsp;&nbsp;&nbsp;Shared Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;**2,650,000** |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 7 | &nbsp;&nbsp;&nbsp;&nbsp;Sole Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;**0** |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 8 | &nbsp;&nbsp;&nbsp;&nbsp;Shared Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;**2,650,000** |

---

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| | |
|:---|:---|
| &nbsp;&nbsp;&nbsp; 9 | &nbsp;&nbsp;&nbsp;&nbsp;Aggregate Amount Beneficially Owned by Each Reporting Person<br>&nbsp;&nbsp;&nbsp;&nbsp;**2,650,000** |
| &nbsp;&nbsp;&nbsp;10 | &nbsp;&nbsp;&nbsp;&nbsp;Check if the Aggregate Amount in Row (9) Excludes Certain Shares<br>&nbsp;&nbsp;&nbsp;&nbsp;**Not Applicable** |
| &nbsp;&nbsp;&nbsp;11 | &nbsp;&nbsp;&nbsp;&nbsp;Percent of Class Represented by Amount in Row 9<br>&nbsp;&nbsp;&nbsp;&nbsp;**5.1%** |
| &nbsp;&nbsp;&nbsp;12 | &nbsp;&nbsp;&nbsp;&nbsp;Type of Reporting Person<br>&nbsp;&nbsp;&nbsp;&nbsp;**CO** |

---

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CUSIP No. 74006W108 Schedule 13G Page 4 of 9

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| | |
|:---|:---|
| &nbsp;&nbsp;&nbsp; 1 | &nbsp;&nbsp;&nbsp;&nbsp;Names of Reporting Persons<br>&nbsp;&nbsp;&nbsp;&nbsp;**James Huang**  |
| &nbsp;&nbsp;&nbsp; 2 | &nbsp;&nbsp;&nbsp;&nbsp;Check the Appropriate Box if a Member of a Group<br> &nbsp;&nbsp;&nbsp;&nbsp;(a) ☐ (b) ☐ |
| &nbsp;&nbsp;&nbsp; 3 | &nbsp;&nbsp;&nbsp;&nbsp;SEC Use Only |
| &nbsp;&nbsp;&nbsp; 4 | &nbsp;&nbsp;&nbsp;&nbsp;Citizenship or Place of Organization<br>&nbsp;&nbsp;&nbsp;&nbsp;**Republic of China** |

---

---

| | | |
|:---|:---|:---|
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 5 | &nbsp;&nbsp;&nbsp;&nbsp;Sole Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;**0** |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 6 | &nbsp;&nbsp;&nbsp;&nbsp;Shared Voting Power<br>&nbsp;&nbsp;&nbsp;&nbsp;**2,650,000** |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 7 | &nbsp;&nbsp;&nbsp;&nbsp;Sole Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;**0** |
| &nbsp;&nbsp;&nbsp; Number of<br> Shares<br> Beneficially <br> Owned by<br> Each<br> Reporting<br> Person<br> With | 8 | &nbsp;&nbsp;&nbsp;&nbsp;Shared Dispositive Power<br>&nbsp;&nbsp;&nbsp;&nbsp;**2,650,000** |

---

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| | |
|:---|:---|
| &nbsp;&nbsp;&nbsp; 9 | &nbsp;&nbsp;&nbsp;&nbsp;Aggregate Amount Beneficially Owned by Each Reporting Person<br>&nbsp;&nbsp;&nbsp;&nbsp;**2,650,000** |
| &nbsp;&nbsp;&nbsp;10 | &nbsp;&nbsp;&nbsp;&nbsp;Check if the Aggregate Amount in Row (9) Excludes Certain Shares<br>&nbsp;&nbsp;&nbsp;&nbsp;**Not Applicable** |
| &nbsp;&nbsp;&nbsp;11 | &nbsp;&nbsp;&nbsp;&nbsp;Percent of Class Represented by Amount in Row 9<br>&nbsp;&nbsp;&nbsp;&nbsp;**5.1%** |
| &nbsp;&nbsp;&nbsp;12 | &nbsp;&nbsp;&nbsp;&nbsp;Type of Reporting Person<br>&nbsp;&nbsp;&nbsp;&nbsp;**IN** |

---

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CUSIP No. 74006W108 Schedule 13G Page 5 of 9

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| | |
|:---|:---|
| **ITEM 1.** | **(a) Name of Issuer:**  |

---

Praxis Precision Medicines, Inc. (the "Issuer").

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**(b)** **Address of Issuer's Principal Executive Offices:** 

99 High Street, 30th floor

Boston, MA 02110.

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| | |
|:---|:---|
| **ITEM 2.** | **(a) Name of Person Filing:**  |

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Each of the following is hereinafter individually referred to as a "Reporting Person" and collectively as the "Reporting Persons." This statement is filed on behalf of:

Panacea Opportunity Fund I, L.P.

Panacea Opportunity Fund I GP Company, Ltd.

Panacea Innovation Limited

James Huang

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**(b)** **Address of Principal Business Office:** 

The business address of each of the Reporting Persons is c/o Maples Corporate Services Limited, Ugland House, Grand Cayman KY1-1104, Cayman Islands.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**(c)** **Citizenship of each Reporting Person is:** 

Mr. Huang is a citizen of the Republic of China. The remaining Reporting Persons are organized under the laws of the Cayman Islands.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**(d)** **Title of Class of Securities:** 

Common Stock, par value $0.0001 per share ("Common Stock")

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**(e)** **CUSIP Number:** 

74006W108

**ITEM 3.**

Not applicable.

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CUSIP No. 74006W108 Schedule 13G Page 6 of 9

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| | |
|:---|:---|
| **ITEM 4.** | **Ownership.**  |

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**(a-c)**

The ownership information presented below represents beneficial ownership of shares of Common Stock as of the date of this filing, based upon 52,393,118 shares of Common Stock outstanding as of February 3, 2023, as disclosed in the Issuer's Annual Report on Form 10-K, filed with the Securities and Exchange Commission on February 7, 2023.

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| **Reporting Person** | **Amount**<br> **beneficially**<br> **owned** | **Percent**<br> **of class:** | **Sole<br>power<br>to vote<br>or to<br>direct<br>the vote:** | **Shared<br>power to<br>vote or to<br>direct the<br>vote:** | **Sole<br>power to<br>dispose or<br>to direct<br>the<br>disposition**<br> **of:** | **Shared**<br> **power to**<br> **dispose or**<br> **to direct**<br> **the**<br> **disposition**<br> **of:** |
|  Panacea Opportunity Fund I, L.P. | 2650000 | 5.1% | 0 | 2650000 | 0 | 2650000 |
|  Panacea Opportunity Fund I GP Company, Ltd. | 2650000 | 5.1% | 0 | 2650000 | 0 | 2650000 |
|  Panacea Innovation Limited | 2650000 | 5.1% | 0 | 2650000 | 0 | 2650000 |
|  James Huang | 2650000 | 5.1% | 0 | 2650000 | 0 | 2650000 |

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Panacea Opportunity Fund I, L.P. is the record holder of the Common Stock reported herein.

James Huang is the sole owner of Panacea Innovation Limited, which is the sole owner of Panacea Opportunity Fund I GP Company, Ltd., which is the general partner of Panacea Opportunity Fund I, L.P. As a result, each of the Reporting Persons may be deemed to share beneficial ownership of the Common Stock directly reported herein, but each disclaims such beneficial ownership.

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| | |
|:---|:---|
| **ITEM 5.** | **Ownership of Five Percent or Less of a Class.**  |

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Not applicable.

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| | |
|:---|:---|
| **ITEM 6.** | **Ownership of More than Five Percent on Behalf of Another Person.**  |

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Not applicable.

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| | |
|:---|:---|
| **ITEM 7.** | **Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company.**  |

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Not applicable.

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| | |
|:---|:---|
| **ITEM 8.** | **Identification and Classification of Members of the Group.**  |

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Not applicable.

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| | |
|:---|:---|
| **ITEM 9.** | **Notice of Dissolution of Group.**  |

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Not applicable.

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CUSIP No. 74006W108 Schedule 13G Page 7 of 9

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| | |
|:---|:---|
| **ITEM 10.** | **Certification.**  |

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By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under §240.14a-11.

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CUSIP No. 74006W108 Schedule 13G Page 8 of 9

**SIGNATURE** 

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

**Date**: March 10, 2023

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| | |
|:---|:---|
| **Panacea Opportunity Fund I, L.P.** | **Panacea Opportunity Fund I, L.P.** |
| By: Panacea Opportunity Fund I GP Company, Ltd., its general partner | By: Panacea Opportunity Fund I GP Company, Ltd., its general partner |
| By: Panacea Innovation Limited, its sole owner | By: Panacea Innovation Limited, its sole owner |
| By: | /s/ James Huang |
| Name: | James Huang |
| Title: | Founding Managing Partner |
| **Panacea Opportunity Fund I GP Company, Ltd.** | **Panacea Opportunity Fund I GP Company, Ltd.** |
| By: Panacea Innovation Limited, its sole owner | By: Panacea Innovation Limited, its sole owner |
| By: | /s/ James Huang |
| Name: | James Huang |
| Title: | Founding Managing Partner |
| **Panacea Innovation Limited** | **Panacea Innovation Limited** |
| By: | /s/ James Huang |
| Name: | James Huang |
| Title: | Founding Managing Partner |
| **James Huang** | **James Huang** |
| /s/ James Huang | /s/ James Huang |

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CUSIP No. 74006W108 Schedule 13G Page 9 of 9

**LIST OF EXHIBITS** 

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| | |
|:---|:---|
| **Exhibit No.** | **Description** |
| 99 | Joint Filing Agreement. |

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## Ex-99

**Exhibit 99** 

**JOINT FILING AGREEMENT** 

In accordance with Rule 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree that they are jointly filing this statement on Schedule 13G. Each of them is responsible for the timely filing of such statement and any amendments thereto, and for the completeness and accuracy of the information concerning such person contained therein; but none of them is responsible for the completeness or accuracy of the information concerning the other persons making the filing, unless such person knows or has reason to believe that such information is inaccurate.

IN WITNESS WHEREOF, the undersigned hereby execute this Joint Filing Agreement as of the 10<sup>th</sup> day of March, 2023.

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| | |
|:---|:---|
| **Panacea Opportunity Fund I, L.P.** | **Panacea Opportunity Fund I, L.P.** |
| By: Panacea Opportunity Fund I GP Company, Ltd., its general partner | By: Panacea Opportunity Fund I GP Company, Ltd., its general partner |
| By: Panacea Innovation Limited, its sole owner | By: Panacea Innovation Limited, its sole owner |
| By: | /s/ James Huang |
| Name: | James Huang |
| Title: | Founding Managing Partner |
| **Panacea Opportunity Fund I GP Company, Ltd.** | **Panacea Opportunity Fund I GP Company, Ltd.** |
| By: Panacea Innovation Limited, its sole owner | By: Panacea Innovation Limited, its sole owner |
| By: | /s/ James Huang |
| Name: | James Huang |
| Title: | Founding Managing Partner |
| **Panacea Innovation Limited** | **Panacea Innovation Limited** |
| By: | /s/ James Huang |
| Name: | James Huang |
| Title: | Founding Managing Partner |
| **James Huang** | **James Huang** |
| /s/ James Huang | /s/ James Huang |

---