# EDGAR Filing Document

**Accession Number:** 0001217234
**File Stem:** 0001217234-25-000062
**Filing Date:** 2025-11
**Character Count:** 28760
**Document Hash:** c6327e9692b4e0ef5ea3969b360433c6
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001217234-25-000062.hdr.sgml**: 20251104

**ACCESSION NUMBER**: 0001217234-25-000062

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 14

**CONFORMED PERIOD OF REPORT**: 20251104

**ITEM INFORMATION**: Results of Operations and Financial Condition

**ITEM INFORMATION**: Regulation FD Disclosure

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20251104

**DATE AS OF CHANGE**: 20251104

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** CareDx, Inc.
- **CENTRAL INDEX KEY:** 0001217234
- **STANDARD INDUSTRIAL CLASSIFICATION:** SERVICES-MEDICAL LABORATORIES [8071]
- **ORGANIZATION NAME:** 08 Industrial Applications and Services
- **EIN:** 943316839
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-36536
- **FILM NUMBER:** 251449059

**BUSINESS ADDRESS:**
- **STREET 1:** 8000 MARINA BLVD
- **STREET 2:** 4TH FLOOR
- **CITY:** BRISBANE
- **STATE:** CA
- **ZIP:** 94005
- **BUSINESS PHONE:** 415-287-2300

**MAIL ADDRESS:**
- **STREET 1:** 8000 MARINA BLVD
- **STREET 2:** 4TH FLOOR
- **CITY:** BRISBANE
- **STATE:** CA
- **ZIP:** 94005

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** XDx, Inc.
- **DATE OF NAME CHANGE:** 20071010

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** EXPRESSION DIAGNOSTICS INC
- **DATE OF NAME CHANGE:** 20030203

?xml version='1.0' encoding='ASCII'? cdna-20251104

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**Washington, D.C. 20549** 

**FORM 8-K**

**CURRENT REPORT** 

**PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934** 

**Date of Report (Date of earliest event reported): November 4, 2025** 

**CAREDX, INC.** 

**(Exact Name of Registrant as Specified in its Charter)** 

---

| | | |
|:---|:---|:---|
| **Delaware** | **001-36536** | **94-3316839** |
| **(State or Other Jurisdiction**<br>**of Incorporation)** | **(Commission**<br>**File Number)** | **(IRS Employer**<br>**Identification No.)** |

---

**8000 Marina Boulevard, 4th Floor**

**Brisbane, California 94005** 

**(Address of Principal Executive Offices) (Zip Code)** 

**(415) 287-2300** 

**Registrant's telephone number, including area code** 

**N/A** 

**(Former Name, or Former Address, if Changed Since Last Report)** 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Exchange Act:

---

| | | |
|:---|:---|:---|
| **(Title of each class)** | **(Trading Symbol)** | **(Name of exchange on which registered)** |
| **Common Stock, $0.001 Par Value** | **CDNA** | **The Nasdaq Stock Market LLC** |

---

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

------

**Item 2.02 Results of Operations and Financial Condition.** 

On November 4, 2025, CareDx, Inc. (the "Company") issued a press release announcing its financial results for the quarter ended September 30, 2025. A copy of the press release is attached hereto as Exhibit 99.1 and is incorporated herein by reference.

The information in this Item 2.02, including the press release attached hereto as Exhibit 99.1, is intended to be furnished under Item 2.02 and Item 9.01 of Form 8-K and shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liabilities of that Section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended (the "Securities Act"), except as shall be expressly set forth by specific reference in such a filing.

**Item 7.01. Regulation FD Disclosure.** 

The Company is furnishing a press release, attached as Exhibit 99.1 to this Current Report on Form 8-K (the "Press Release"), which the Company intends to post on the Company's website. The Press Release is current as of November 4, 2025, and the Company disclaims any obligation to update this material in the future.

**Item 9.01. Financial Statements and Exhibits.** 

(d) Exhibits.

---

| | |
|:---|:---|
| **Exhibit No.** | **<u>Description</u>** |
| 99.1 | <u>[Press Release issued by CareDx, Inc., dated November 4, 2025.](cdna-20251104_earningsrele.htm)</u> |
| 104 | Cover Page Interactive Data File, formatted in Inline Extensible Business Reporting Language (iXBRL). |

---

------

**SIGNATURES** 

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

---

| | | |
|:---|:---|:---|
| Date: November 4, 2025 | CAREDX, INC. |  |
|  | By: | /s/ NATHAN SMITH |
|  |  | Nathan Smith |
|  |  | Chief Financial Officer |
|  |  | (Principal Accounting and Financial Officer) |

---

## Exhibit 99.1

**Exhibit 99.1**

![logoa.jpg](logoa.jpg)

**CareDx Announces Third Quarter 2025 Financial Results**

*Total Revenue of $100 Million Increased 21% Year-Over-Year*

*Grew Testing Services Volume to Approximately 50,300, Increase of 13% Year-Over-Year*

*Raised 2025 Revenue Guidance to $372 Million to $376 Million*

BRISBANE, Calif., November 4, 2025, CareDx, Inc. (Nasdaq: CDNA) — The Transplant Company — a leading precision medicine company focused on the discovery, development and commercialization of clinically differentiated, high-value healthcare solutions for transplant patients and caregivers, today reported financial results for the third quarter ended September 30, 2025.

**Third Quarter 2025 Financial Highlights**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Revenue of $100.1 million, an increase of 21% year-over-year

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Testing services revenue of $72.2 million, an increase of 19% year-over-year

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Testing services volume of 50,300, an increase of 13% year-over-year

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• GAAP net income of $1.7 million, compared to a GAAP net loss of $10.6 million in the third quarter of 2024

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Adjusted EBITDA of $15.3 million, compared to $6.9 million in the third quarter of 2024

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Cash, cash equivalents and marketable securities of $194.2 million as of September 30, 2025, net of a $25.6 million share repurchase carried out during the quarter; no debt outstanding as of September 30, 2025

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Raised 2025 revenue guidance to $372 million to $376 million and raised 2025 adjusted EBITDA guidance to $35 million to $39 million

**Recent Business Highlights**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**•** Appointed Suresh Gunasekaran, president and CEO of UCSF Health, an internationally renowned health system executive, to the CareDx Board of Directors

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Appointed Jeff Teuteberg, MD, a leader in transplant medicine with a track record of clinical innovation, research, and patient advocacy, as Chief Medical Officer

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Published second SHORE study, validating AlloSure Heart as a reliable biomarker for detecting antibody-mediated rejection (AMR) in heart transplant patients, reinforcing that HeartCare can detect both AMR and ACR

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Introduced HistoMap Kidney, a tissue-based gene expression profiler that integrates advanced histopathology with molecular insights to support more precise and timely decisions for patients

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Submitted extensive, evidence-based comment letter intended to inform final draft of LCD policy

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Completed first Epic Aura implementation and anticipate initiating approximately 20 implementations by year-end 2025

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Launched AlloSeq Tx11, a next-generation HLA typing solution with enhanced Class II coverage and expanded non-HLA markers to support broader transplant risk profiling

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Introduced Score 7.0, modernized analysis software for QTYPE built for scalability and regulatory alignment that supports future ABO typing and IVDR compliance

------

"We achieved record-setting third quarter 2025 financial results, a testament to our market leadership that has been established through a deep commitment to innovation and transplant patient care," said John W. Hanna, President and CEO of CareDx. "Our strategy to extend that leadership and deliver long-term profitable growth is guided by putting our customers at the center of everything we do, and we believe that strategy is working."

**Q3 2025 Financial Results**

Total revenue was $100.1 million compared to $82.9 million in the third quarter of 2024, an increase of 21%.

Testing services revenue was $72.2 million, compared to $60.8 million in the third quarter of 2024, an increase of 19%.

Patient and Digital Solutions revenue was $15.4 million, compared to $11.9 million in the third quarter of 2024, an increase of 30%.

Product revenue was $12.5 million, an increase of 22% compared to $10.2 million in the third quarter of 2024.

GAAP net income was $1.7 million compared to GAAP net loss of $10.6 million in the third quarter 2024. Basic and diluted GAAP net income per share was $0.03 compared to basic and diluted GAAP net loss per share of $0.20 in the third quarter of 2024.

Non-GAAP net income was $14.9 million compared to $8.0 million in the third quarter of 2024. Diluted non-GAAP net income per share was $0.28 compared to $0.14 in the third quarter of 2024.

Adjusted EBITDA was $15.3 million compared to $6.9 million in the third quarter of 2024.

**2025 Guidance**

For the full year 2025, CareDx now expects revenue to be in the range of $372 million to $376 million, compared to the $367 million to $373 million range that was previously disclosed. The Company now expects full year 2025 adjusted EBITDA to be in the range of $35 million to $39 million, compared to the $29 million to $33 million range that was previously disclosed.

**About CareDx – The Transplant Company**

CareDx, Inc., headquartered in Brisbane, California, is a leading precision medicine solutions company focused on the discovery, development, and commercialization of clinically differentiated, high-value healthcare solutions for transplant patients and caregivers. CareDx offers testing services, products, and digital healthcare solutions along the pre- and post-transplant patient journey and is the leading provider of genomics-based information for transplant patients. For more information, please visit: www.CareDx.com.

**Forward Looking Statements**

This press release includes forward-looking statements, including expectations regarding the achievement of CareDx's financial and operational goals and its expectations and prospects for 2025. These forward-looking statements are based upon information that is currently available to CareDx and its current expectations, speak only as of the date hereof, and are subject to numerous risks and uncertainties, all of which are difficult to predict and many of which are beyond CareDx's control, that could cause the actual results to differ materially from those projected, including general economic and market factors, and global economic and marketplace uncertainties, among others discussed in CareDx's filings with the Securities and Exchange Commission (the "SEC"), including, but not limited to, the Annual Report on Form 10-K for the fiscal year ended December 31, 2024 filed by CareDx with the SEC on February 28, 2025, and other reports that CareDx has filed with the SEC. Any of these may cause CareDx's actual results, performance, or achievements to differ materially and adversely from those anticipated or implied by CareDx's forward-looking statements. You are cautioned not to place undue reliance on these forward-looking statements. CareDx expressly disclaims any obligation, except as required by law, or undertaking to update or revise any such forward-looking statements, whether as a result of new information, future events or otherwise.

------

**Use of Non-GAAP Financial Measures**

CareDx has presented in this release certain financial information in accordance with U.S. Generally Accepted Accounting Principles ("GAAP") and also on a non-GAAP basis, including non-GAAP cost of testing services, non-GAAP cost of product, non-GAAP cost of patient and digital solutions, non-GAAP research and development expenses, non-GAAP sales and marketing expenses, non-GAAP general and administrative expenses, non-GAAP other income, net, non-GAAP income tax expense, non-GAAP gross profit, non-GAAP gross margin (%), non-GAAP operating expenses, non-GAAP net income, non-GAAP basic and diluted net income per share and adjusted EBITDA. These non-GAAP financial measures are not meant to be considered superior to or a substitute for financial measures calculated in accordance with GAAP, and investors are cautioned that there are material limitations associated with the use of non-GAAP financial measures as an analytical tool.

We define non-GAAP net income and per share results as the GAAP net income (loss) and per share results excluding the impacts of stock-based compensation expense; acquisition-related amortization of purchased intangible assets and related tax effects; costs involved with completing an acquisition; changes in estimated fair value of contingent consideration; litigation settlement expense; transformational initiative costs; and certain other charges presented in the reconciliation in this release. We define adjusted EBITDA as non-GAAP net income before interest income, income tax expense, depreciation expense and other (income) expense, net.

We are presenting these non-GAAP financial measures to assist investors in assessing our operating results through the eyes of management and because we believe that these measures provide an additional tool for investors to use in comparing our core business operating results over multiple periods where certain items may vary independent of business performance. Management believes this non-GAAP information is useful for investors, when considered in conjunction with CareDx's GAAP financial statements, because management uses such information internally for its operating, budgeting and financial planning purposes. Non-GAAP information is not prepared under a comprehensive set of accounting rules and should only be used to supplement an understanding of CareDx's operating results as reported under GAAP. These non-GAAP financial measures should not be considered in isolation from, or as a substitute for, financial information prepared in accordance with GAAP. These non-GAAP financial measures are not necessarily comparable to similarly titled measures presented by other companies. A reconciliation between GAAP and non-GAAP financial information is provided immediately following the financial tables. A reconciliation of the forecasted range for adjusted EBITDA for 2025 is not included in this release due to the number of variables in the projected range and because we are currently unable to quantify accurately certain amounts that would be required to be included in the U.S. GAAP measure or the individual adjustments for such reconciliation.

------

**CareDx, Inc.**

**Condensed Consolidated Statements of Operations** 

**(Unaudited)**

*(In thousands, except share and per share data)*

---

| | | |
|:---|:---|:---|
| | **Three Months Ended September 30,** | **Three Months Ended September 30,** |
| | **2025** | **2024** |
| Revenue: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Testing services revenue | $72168 | $60807 |
| &nbsp;&nbsp;&nbsp;&nbsp;Product revenue | 12478 | 10212 |
| &nbsp;&nbsp;&nbsp;&nbsp;Patient and digital solutions revenue | 15409 | 11864 |
| Total revenue | 100055 | 82883 |
| Operating expenses: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Cost of testing services | 14705 | 13447 |
| &nbsp;&nbsp;&nbsp;&nbsp;Cost of product | 5629 | 6212 |
| &nbsp;&nbsp;&nbsp;&nbsp;Cost of patient and digital solutions | 10320 | 7913 |
| &nbsp;&nbsp;&nbsp;&nbsp;Research and development | 16769 | 17486 |
| &nbsp;&nbsp;&nbsp;&nbsp;Sales and marketing | 24449 | 19802 |
| &nbsp;&nbsp;&nbsp;&nbsp;General and administrative | 28429 | 31744 |
| Total operating expenses | 100301 | 96604 |
| Loss from operations | (246) | (13721) |
| Other income: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Interest income, net | 2013 | 3001 |
| &nbsp;&nbsp;&nbsp;&nbsp;Other (expense) income, net | (107) | 283 |
| Total other income | 1906 | 3284 |
| Income (loss) before income taxes | 1660 | (10437) |
| Income tax benefit (expense) | 15 | (200) |
| Net income (loss) | $1675 | $(10637) |
| Net income (loss) per share: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Basic | $0.03 | $(0.20) |
| &nbsp;&nbsp;&nbsp;&nbsp;Diluted | $0.03 | $(0.20) |
| Weighted-average shares used to compute net income (loss) per share: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Basic | 52507582 | 52903338 |
| &nbsp;&nbsp;&nbsp;&nbsp;Diluted | 53736790 | 52903338 |

---

------

**CareDx, Inc.**

**Condensed Consolidated Balance Sheets**

**(Unaudited)**

*(In thousands)*

---

| | | |
|:---|:---|:---|
| | **September 30, 2025** | **December 31, 2024** |
| **Assets** | | |
| Current assets: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Cash and cash equivalents | $91435 | $114689 |
| &nbsp;&nbsp;&nbsp;&nbsp;Marketable securities | 102782 | 145964 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accounts receivable | 47844 | 64605 |
| &nbsp;&nbsp;&nbsp;&nbsp;Inventory | 28328 | 19503 |
| &nbsp;&nbsp;&nbsp;&nbsp;Prepaid and other current assets | 29891 | 7071 |
| Total current assets | 300280 | 351832 |
| Property and equipment, net | 30845 | 33552 |
| Operating leases right-of-use assets | 24047 | 24340 |
| Intangible assets, net | 33446 | 38184 |
| Goodwill | 40336 | 40336 |
| Restricted cash | 551 | 585 |
| Other assets | 2802 | 2221 |
| Total assets | $432307 | $491050 |
| **Liabilities and stockholders' equity** |  |  |
| Current liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Accounts payable | $11597 | $7686 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accrued compensation | 23237 | 38333 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accrued litigation settlement expense | 20250 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Accrued and other liabilities | 43960 | 43352 |
| Total current liabilities | 99044 | 89371 |
| Deferred tax liability | 117 | 164 |
| Contingent consideration | 160 | 174 |
| Operating lease liability, less current portion | 21212 | 22263 |
| Other liabilities | 634 | 645 |
| Total liabilities | 121167 | 112617 |
| Commitments and contingencies |  |  |
| Stockholders' equity: |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Common stock | 51 | 51 |
| &nbsp;&nbsp;&nbsp;&nbsp;Additional paid-in capital | 1036091 | 1013193 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accumulated other comprehensive loss | (5955) | (8569) |
| &nbsp;&nbsp;&nbsp;&nbsp;Accumulated deficit | (719047) | (626242) |
| Total stockholders' equity | 311140 | 378433 |
| Total liabilities and stockholders' equity | $432307 | $491050 |

---

------

**CareDx, Inc.**

**Reconciliation of GAAP to Non-GAAP Financial Measures**

**(Unaudited)**

*(In thousands)*

---

| | | |
|:---|:---|:---|
| | **Three Months Ended September 30,** | **Three Months Ended September 30,** |
| | **2025** | **2024** |
| **Cost of testing services reconciliation:** |  |  |
| GAAP cost of testing services | $14705 | $13447 |
| &nbsp;&nbsp;&nbsp;&nbsp;Stock-based compensation expense | (299) | (418) |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring costs | (120) |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition related-amortization of purchased intangibles | (348) | (329) |
| Non-GAAP cost of testing services | $13938 | $12700 |
| **Cost of product reconciliation:** |  |  |
| GAAP cost of product | $5629 | $6212 |
| &nbsp;&nbsp;&nbsp;&nbsp;Stock-based compensation expense | (51) | (234) |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition related-amortization of purchased intangibles | (447) | (419) |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring costs | (11) |  |
| Non-GAAP cost of product | $5120 | $5559 |
| **Cost of patient and digital solutions reconciliation:** |  |  |
| GAAP cost of patient and digital solutions | $10320 | $7913 |
| &nbsp;&nbsp;&nbsp;&nbsp;Stock-based compensation expense | (118) | (326) |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition related-amortization of purchased intangibles | (152) | (170) |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring costs | 8 |  |
| Non-GAAP cost of patient and digital solutions | $10058 | $7417 |
| **Research and development expenses reconciliation:** |  |  |
| GAAP research and development expenses | $16769 | $17486 |
| &nbsp;&nbsp;&nbsp;&nbsp;Stock-based compensation expense | (1146) | (1775) |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring costs | (174) |  |
| Non-GAAP research and development expenses | $15449 | $15711 |
| **Sales and marketing expenses reconciliation:** |  |  |
| GAAP sales and marketing expenses | $24449 | $19802 |
| &nbsp;&nbsp;&nbsp;&nbsp;Stock-based compensation expense | (1782) | (2786) |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition related-amortization of purchased intangibles | (655) | (634) |
| &nbsp;&nbsp;&nbsp;&nbsp;Transformational initiative costs\* | (183) |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring costs | (233) |  |
| Non-GAAP sales and marketing expenses | $21596 | $16382 |
| **General and administrative expenses reconciliation:** |  |  |
| GAAP general and administrative expenses | $28429 | $31744 |
| &nbsp;&nbsp;&nbsp;&nbsp;Stock-based compensation expense | (5022) | (11384) |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in estimated fair value of contingent consideration |  | (232) |
| &nbsp;&nbsp;&nbsp;&nbsp;Transformational initiative costs\* | (341) |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Impairment of intangible asset | (2258) |  |
| Non-GAAP general and administrative expenses | $20808 | $20128 |
| **Total other income reconciliation:** |  |  |
| GAAP other income | $1906 | $3284 |
| Non-GAAP other income | $1906 | $3284 |
| **Income tax benefit (expense) reconciliation:** |  |  |
| GAAP income tax benefit (expense) | $15 | $(200) |
| &nbsp;&nbsp;&nbsp;&nbsp;Tax effect related to amortization of purchased intangibles | (111) | (102) |
| Non-GAAP income tax expense | $(96) | $(302) |

---

\* Transformational initiative costs consist of consulting expenses which relate to our ongoing transformation strategy that we have undertaken as a series of initiatives focused on operational excellence, enterprise-wide efficiency, and long-term strategic growth, including rebranding costs.

------

**CareDx, Inc.**

**GAAP and Non-GAAP Operating Expenses**

**(Unaudited)**

*(In thousands)*

---

| | | |
|:---|:---|:---|
| | **Three Months Ended September 30,** | **Three Months Ended September 30,** |
| | **2025** | **2024** |
| GAAP operating expenses: |  |  |
| &nbsp;&nbsp;Research and development | $16769 | $17486 |
| &nbsp;&nbsp;Sales and marketing | 24449 | 19802 |
| &nbsp;&nbsp;General and administrative | 28429 | 31744 |
| Total GAAP operating expenses | $69647 | $69032 |
| Non-GAAP operating expenses: |  |  |
| &nbsp;&nbsp;Research and development | $15449 | $15711 |
| &nbsp;&nbsp;Sales and marketing | 21596 | 16382 |
| &nbsp;&nbsp;General and administrative | 20808 | 20128 |
| Total Non-GAAP operating expenses | $57853 | $52221 |

---

------

**CareDx, Inc.**

**Reconciliation of GAAP to Non-GAAP Gross Profit and Gross Margin**

**(Unaudited)**

*(In thousands, except percentages)*

---

| | | |
|:---|:---|:---|
| | **Three Months Ended September 30,** | **Three Months Ended September 30,** |
| | **2025** | **2024** |
| GAAP total revenue | $100055 | $82883 |
| GAAP cost of sales | 30654 | 27572 |
| GAAP gross profit | 69401 | 55311 |
| GAAP gross margin % | 69% | 67% |
| &nbsp;&nbsp;&nbsp;&nbsp;Stock-based compensation expense | 468 | 978 |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring costs | 123 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition related-amortization of purchased intangibles | 947 | 918 |
| Non-GAAP gross profit | $70939 | $57207 |
| Non-GAAP gross margin % | 71% | 69% |

---

------

**CareDx, Inc.**

**Reconciliation of GAAP to Non-GAAP Financial Measures**

**(Unaudited)**

*(In thousands, except share and per share data)*

---

| | | |
|:---|:---|:---|
| | **Three Months Ended September 30,** | **Three Months Ended September 30,** |
| | **2025** | **2024** |
| GAAP net income (loss) | $1675 | $(10637) |
| &nbsp;&nbsp;&nbsp;&nbsp;Stock-based compensation expense | 8418 | 16923 |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition related-amortization of purchased intangibles | 1602 | 1552 |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in estimated fair value of contingent consideration |  | 232 |
| &nbsp;&nbsp;&nbsp;&nbsp;Tax effect related to amortization of purchased intangibles | (111) | (102) |
| &nbsp;&nbsp;&nbsp;&nbsp;Impairment of intangible asset | 2258 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Transformational initiative costs\* | 524 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring costs | 530 |  |
| Non-GAAP net income | $14896 | $7968 |
| GAAP basic net income (loss) per share | $0.03 | $(0.20) |
| GAAP diluted net income (loss) per share | $0.03 | $(0.20) |
| Non-GAAP basic net income per share | $0.28 | $0.15 |
| Non-GAAP diluted net income per share | $0.28 | $0.14 |
| Shares used in computing non-GAAP basic net income per share | 52507582 | 52903338 |
| Shares used in computing non-GAAP diluted net income per share | 53736790 | 57699624 |

---

\* Transformational initiative costs consist of consulting expenses which relate to our ongoing transformation strategy that we have undertaken as a series of initiatives focused on operational excellence, enterprise-wide efficiency, and long-term strategic growth, including rebranding costs.

------

**CareDx, Inc.**

**Reconciliation of Non-GAAP to Adjusted EBITDA**

**(Unaudited)**

*(In thousands)*

---

| | | |
|:---|:---|:---|
| | **Three Months Ended September 30,** | **Three Months Ended September 30,** |
| | **2025** | **2024** |
| GAAP net income (loss) | $1675 | $(10637) |
| &nbsp;&nbsp;&nbsp;&nbsp;Stock-based compensation expense | 8418 | 16923 |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition related-amortization of purchased intangibles | 1602 | 1552 |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in estimated fair value of contingent consideration |  | 232 |
| &nbsp;&nbsp;&nbsp;&nbsp;Tax effect related to amortization of purchased intangibles | (111) | (102) |
| &nbsp;&nbsp;&nbsp;&nbsp;Impairment of intangible asset | 2258 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Transformational initiative costs\* | 524 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring costs | 530 |  |
| Non-GAAP net income | 14896 | 7968 |
| &nbsp;&nbsp;&nbsp;&nbsp;Interest income | (2013) | (3001) |
| &nbsp;&nbsp;&nbsp;&nbsp;Income tax expense | 96 | 302 |
| &nbsp;&nbsp;&nbsp;&nbsp;Depreciation expense | 2213 | 1919 |
| &nbsp;&nbsp;&nbsp;&nbsp;Other expense (income), net | 107 | (283) |
| Adjusted EBITDA | $15299 | $6905 |

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\* Transformational initiative costs consist of consulting expenses which relate to our ongoing transformation strategy that we have undertaken as a series of initiatives focused on operational excellence, enterprise-wide efficiency, and long-term strategic growth, including rebranding costs.

**CareDx, Inc.** 

Media Relations

Natasha Moshirian Wagner

<u>nwagner@CareDx.com</u> 

Investor Relations

Tina Jacobsen

<u>investor@CareDx.com</u> 

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