# EDGAR Filing Document

**Accession Number:** 0001384101
**File Stem:** 0001384101-25-000081
**Filing Date:** 2025-6
**Character Count:** 25216
**Document Hash:** aee097feaede8caada6116a50e238535
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001384101-25-000081.hdr.sgml**: 20250617

**ACCESSION NUMBER**: 0001384101-25-000081

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 15

**FILED AS OF DATE**: 20250617

**DATE AS OF CHANGE**: 20250617

**EFFECTIVENESS DATE**: 20250617

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** VERACYTE, INC.
- **CENTRAL INDEX KEY:** 0001384101
- **STANDARD INDUSTRIAL CLASSIFICATION:** SERVICES-MEDICAL LABORATORIES [8071]
- **ORGANIZATION NAME:** 08 Industrial Applications and Services
- **EIN:** 205455398
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-288113
- **FILM NUMBER:** 251053852

**BUSINESS ADDRESS:**
- **STREET 1:** 6000 SHORELINE COURT, SUITE 300
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080
- **BUSINESS PHONE:** (650) 243-6300

**MAIL ADDRESS:**
- **STREET 1:** 6000 SHORELINE COURT, SUITE 300
- **CITY:** SOUTH SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94080

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** CALDEROME INC
- **DATE OF NAME CHANGE:** 20061219

As filed with the Securities and Exchange Commission on June 17, 2025

Registration No. 333-

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

____________________

**FORM S-8**

**REGISTRATION STATEMENT**

**UNDER**

**THE SECURITIES ACT OF 1933**

____________________

**VERACYTE, INC.**

(Exact name of registrant as specified in its charter)

---

| | |
|:---|:---|
| Delaware<br>(State or other jurisdiction of<br>incorporation or organization) | 20-5455398<br> (I.R.S. Employer<br>Identification No.) |
| 6000 Shoreline Court, Suite 300<br>South San Francisco, California<br>(Address of Principal Executive Offices) | 94080<br>(Zip Code) |
| Veracyte, Inc. 2023 Equity Incentive Plan | Veracyte, Inc. 2023 Equity Incentive Plan |
| (Full title of the plan) | (Full title of the plan) |
| Marc Stapley<br>Chief Executive Officer<br>6000 Shoreline Court, Suite 300<br>South San Francisco, California<br>(Name and address of agent for service)<br>(650) 243-6300<br>(Telephone number, including area code, of agent for service)<br>Copies to: | Marc Stapley<br>Chief Executive Officer<br>6000 Shoreline Court, Suite 300<br>South San Francisco, California<br>(Name and address of agent for service)<br>(650) 243-6300<br>(Telephone number, including area code, of agent for service)<br>Copies to: |

---

---

| | | |
|:---|:---|:---|
| Jim Krenn, Esq.<br>Morrison & Foerster LLP<br>12531 High Bluff Drive<br>San Diego, CA 92130<br>(858) 720-5100 | Emily Beers, Esq.<br>Morrison & Foerster LLP<br>2100 L Street NW, Suite 900<br>Washington, D.C. 20037<br>(202) 887-1500 | Annie McGuire Esq.<br>Executive Vice President and<br>General Counsel<br>Veracyte, Inc.<br>6000 Shoreline Court, Suite 300<br>South San Francisco, CA 94080<br>(650) 243-6300 |

---

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☒ | Accelerated filer | ☐ |
| Non-accelerated filer | ☐ | Smaller reporting company | ☐ |
| | | Emerging growth company | ☐ |

---

------

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

------

**REGISTRATION OF ADDITIONAL SHARES PURSUANT TO GENERAL INSTRUCTION E**

Pursuant to General Instruction E of Form S-8, Veracyte, Inc. (the "Registrant") is filing this Registration Statement on Form S-8 with the U.S. Securities and Exchange Commission (the "Commission") to register 2,500,000 additional shares (the "Share Increase") of the Registrant's common stock, par value $0.001 per share (the "common stock"), available for issuance under the Registrant's 2023 Equity Incentive Plan, as amended (the "2023 Plan"). At the Registrant's Annual Meeting of Stockholders held on June 17, 2025, the Registrant's stockholders, among other things, approved the Share Increase under the 2023 Plan.

In accordance with General Instruction E of Form S-8, and only with respect to the common stock issuable under the 2023 Plan, this Registration Statement hereby incorporates by reference the contents of (i) the Registrant's Registration Statements on Form S-8 filed with the Commission on October 30, 2013 (File No. 333-191992), March 30, 2015 (File No. 333-203097), March 14, 2016 (File No. 333-210185), March 2, 2017 (File No. 333-216388), February 28, 2018 (File No. 333-223292), February 25, 2019 (File No. 333-229848), February 25, 2020 (File No. 333-236630), February 22, 2021 (File No. 333-253363), March 1, 2022 (File No. 333-263116), March 1, 2023 (File No. 333-270147), in each case as amended by a Post-Effective Amendment No. 1 thereto filed with the Commission on June 8, 2023, and (ii) the Registrant's Registration Statement on Form S-8 filed with the Commission on June 12, 2024 (File No. 333-280150), in each case, to the extent not superseded hereby.

**PART II**

**INFORMATION REQUIRED IN THE REGISTRATION STATEMENT**

**Item 3. Incorporation of Documents by Reference.**

The following documents filed by the Registrant with the Commission are hereby incorporated by reference in this Registration Statement:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;&nbsp;&nbsp;&nbsp;<u>[The Registrant's Annual Report on Form 10-K for the year ended December 31, 202](https://www.sec.gov/ix?doc=/Archives/edgar/data/1384101/000138410125000014/vcyt-20241231.htm)[4](https://www.sec.gov/ix?doc=/Archives/edgar/data/1384101/000138410125000014/vcyt-20241231.htm)[, filed with the Commission on February 2](https://www.sec.gov/ix?doc=/Archives/edgar/data/1384101/000138410125000014/vcyt-20241231.htm)[8](https://www.sec.gov/ix?doc=/Archives/edgar/data/1384101/000138410125000014/vcyt-20241231.htm)[, 202](https://www.sec.gov/ix?doc=/Archives/edgar/data/1384101/000138410125000014/vcyt-20241231.htm)[5](https://www.sec.gov/ix?doc=/Archives/edgar/data/1384101/000138410125000014/vcyt-20241231.htm)[;](https://www.sec.gov/ix?doc=/Archives/edgar/data/1384101/000138410125000014/vcyt-20241231.htm)</u>

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;&nbsp;&nbsp;&nbsp;All other reports filed pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act") since the end of the fiscal year covered by the Registrant's Annual Report referred to in (a) above (other than the portions of these documents not deemed to be filed); and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(c)&nbsp;&nbsp;&nbsp;&nbsp;<u>[The description of the Registrant's](https://www.sec.gov/Archives/edgar/data/1384101/000110465913078343/a13-16266_158a12b.htm)[c](https://www.sec.gov/Archives/edgar/data/1384101/000110465913078343/a13-16266_158a12b.htm)[ommon](https://www.sec.gov/Archives/edgar/data/1384101/000110465913078343/a13-16266_158a12b.htm)[s](https://www.sec.gov/Archives/edgar/data/1384101/000110465913078343/a13-16266_158a12b.htm)[tock contained in Registrant's registration statement on Form 8-A, filed](https://www.sec.gov/Archives/edgar/data/1384101/000110465913078343/a13-16266_158a12b.htm)[with the Commission](https://www.sec.gov/Archives/edgar/data/1384101/000110465913078343/a13-16266_158a12b.htm)[on October 28, 2013 pursuant to Section 12(b) of the Exchange Act](https://www.sec.gov/Archives/edgar/data/1384101/000110465913078343/a13-16266_158a12b.htm)</u>, including any amendment or report filed for the purpose of updating such description, including <u>[Exhibit 4.2](https://www.sec.gov/Archives/edgar/data/1384101/000138410125000014/vcyt-12312024xex42.htm)</u> to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2024, filed with the Commission on February 28, 2025.

In addition, all documents filed by the Registrant pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act (excluding any portions thereof furnished by the Registrant, including information furnished under Item 2.02 and Item 7.01 and any exhibits relating to Item 2.02 or Item 7.01 furnished under Item 9.01 of Form 8-K and any certification required by 18 U.S.C. § 1350), subsequent to the filing of this Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference into this Registration Statement and to be a part hereof from the date of filing such documents. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained in any subsequently filed document which also is deemed to be incorporated by reference herein modifies or supersedes such statement.

------

---

| | |
|:---|:---|
| **Item 8.** | **Exhibits.** |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following exhibits are filed herewith: | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The following exhibits are filed herewith: |

---

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| | | Incorporated by Reference | Incorporated by Reference | Incorporated by Reference | Incorporated by Reference | |
| Exhibit No. | Description | Form | File No. | Exhibit | Filing Date | Filed Herewith |
| 4.1 | <u>[Restated Certificate of Incorporation of the Registrant](https://www.sec.gov/Archives/edgar/data/1384101/000138410123000112/ex32-restatedcertificateof.htm)</u> | 8-K | 001-36156 | 3.2 | 6/9/2023 |  |
| 4.2 | <u>[Amended and Restated Bylaws of the Registrant](https://www.sec.gov/Archives/edgar/data/1384101/000138410123000112/ex33-veracytexamendedandre.htm)</u> | 8-K | 001-36156 | 3.3 | 6/9/2023 |  |
| 4.3 | <u>[Form of Common Stock Certificate](https://www.sec.gov/Archives/edgar/data/1384101/000104746913009631/a2216954zex-4_1.htm)</u> | S-1/A | 333-191282 | 4.1 | 10/15/2013 |  |
| 5.1 | <u>[Opinion of](ex51opinionfors-806172025.htm)[Morrison & Fo](ex51opinionfors-806172025.htm)[erster](ex51opinionfors-806172025.htm)[LLP](ex51opinionfors-806172025.htm)</u> |  |  |  |  | X |
| 23.1 | <u>[Consent of Independent Registered Public Accounting Firm](ex231s-8auditorconsent0617.htm)</u> |  |  |  |  | X |
| 23.2 | <u>[Consent of](ex51opinionfors-806172025.htm)[Morrison](ex51opinionfors-806172025.htm)[&](ex51opinionfors-806172025.htm)[Foerster](ex51opinionfors-806172025.htm)[LLP (included in Exhibit 5.1)](ex51opinionfors-806172025.htm)</u> |  |  |  |  | X |
| 24.1 | <u>[Power of Attorney (contained on signature page hereto).](#i9c2cfa2fa5ca4505a84a999625637f26_7)</u> |  |  |  |  | X |
| 99.1 | <u>[2023 Equity Incentive Plan, as amended](https://www.sec.gov/ix?doc=/Archives/edgar/data/1384101/000138410125000051/vcyt-20250428.htm#ie799047edac24c459423a0886a6e8222_127)</u> | DEF 14-A | 001-36156 | Appendix A | 4/29/2025 |  |
| 99.2 | <u>[Form of agreements under the 2023 Equity Incentive Plan](https://www.sec.gov/Archives/edgar/data/1384101/000138410123000100/ex996-2023eipformofagreeme.htm)</u> | S-8 POS | 333-270147 | 99.6 | 6/8/2023 |  |
| 107.1 | <u>[Filing Fee Table](exfilingfees.htm)</u> |  |  |  |  | X |

---

------

**SIGNATURES**

Pursuant to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized in the City of South San Francisco, State of California, on the 17th day of June 2025.

---

| | |
|:---|:---|
| VERACYTE, INC. | VERACYTE, INC. |
| By: | /s/ MARC STAPLEY |
|  | Marc Stapley<br>*Chief Executive Officer and Director* |

---

------

**POWER OF ATTORNEY**

KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Marc Stapley and Rebecca Chambers and each of them, his or her true and lawful attorneys-in-fact and agents, each with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments, including post-effective amendments, to this Registration Statement on Form S-8, and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that each of said attorneys-in-fact and agents, or his or her substitute or substitutes may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

---

| | | |
|:---|:---|:---|
| **<u>Signature</u>** | **<u>Title</u>** | **<u>Date</u>** |
| /s/ MARC STAPLEY | Chief Executive Officer and Director<br>(Principal Executive Officer) | June 17, 2025 |
| Marc Stapley | Chief Executive Officer and Director<br>(Principal Executive Officer) |  |
| /s/ REBECCA CHAMBERS | Chief Financial Officer <br>(Principal Financial Officer) | June 17, 2025 |
| Rebecca Chambers | Chief Financial Officer <br>(Principal Financial Officer) |  |
| /s/ JONATHAN WYGANT | Chief Accounting Officer (Principal Accounting Officer) | June 17, 2025 |
| Jonathan Wygant | Chief Accounting Officer (Principal Accounting Officer) |  |
| /s/ ROBERT S. EPSTEIN, M.D., M.S. | Chairperson and Director | June 17, 2025 |
| Robert S. Epstein, M.D., M.S. |  |  |
| /s/ ELIAV BARR, M.D. | Director | June 17, 2025 |
| Eliav Barr, M.D. |  |  |
| /s/ MUNA BHANJI | Director | June 17, 2025 |
| Muna Bhanji |  |  |
| /s/ KARIN EASTHAM | Director | June 17, 2025 |
| Karin Eastham |  |  |
| /s/ JENS HOLSTEIN | Director | June 17, 2025 |
| Jens Holstein |  |  |
| /s/ EVAN JONES | Director | June 17, 2025 |
| Evan Jones |  |  |
| /s/ TOM MILLER | Director | June 17, 2025 |
| Tom Miller |  |  |
| /s/ BRENT SHAFER | Director | June 17, 2025 |
| Brent Shafer |  |  |

---

## Ex-Filing

?xml version='1.0' encoding='ASCII'? EX-FILING FEES

---

| |
|:---|
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Calculation of Filing Fee Tables**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **S-8**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **VERACYTE, INC.**  |

---

---

| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Security Type**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Security Class Title**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Fee Calculation Rule**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Amount Registered**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Proposed Maximum Offering Price Per Unit**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Maximum Aggregate Offering Price**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Fee Rate**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Amount of Registration Fee**  |
| 1 | Equity | Common stock, $0.001 par value | Other | 2500000 | $26.385 | $65962500.00 | 0.0001531 | $10098.86 |
| Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: |  | $65962500.00  |  | $10098.86  |
| Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  |  |  |  | $0.00  |
| Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  |  |  |  | $10098.86  |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Offering Note** <br>

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <sup>1</sup> The amount registered represents additional shares of the Registrant's common stock available for issuance pursuant to awards that may be granted under the Veracyte, Inc. 2023 Equity Incentive Plan, as amended (the "Plan"). Pursuant to Rule 416(a) of the Securities Act of 1933, as amended, this Registration Statement also registers an indeterminate number of additional shares that may be issued pursuant to the Plan as a result of any future stock dividend, stock split, recapitalization or any other similar transaction effected without the receipt of consideration which results in an increase in the number of our outstanding shares of common stock. The proposed maximum offering price per share and proposed maximum aggregate offering price for the shares of the common stock covered by this Registration Statement have been estimated in accordance with Rule 457(c) and 457(h) solely for the purpose of calculating the registration fee. The maximum price per share and the maximum aggregate offering price are based upon the average of the high and low prices of the Registrant's common stock as reported on The Nasdaq Stock Market on June 16, 2025, which date is within five business days prior to filing this Registration Statement.

## Exhibit 5.1

**Exhibit 5.1**

---

| | | |
|:---|:---|:---|
| ![image_0.jpg](image_0.jpg) | 2100 L STREET, NW | morrison & foerster llp<br>amsterdam, austin, berlin, boston, brussels, denver, hong kong, london, los angeles, miami, new york, palo alto, san diego, san francisco, shanghai, singapore, tokyo, washington, d.c. |
| ![image_0.jpg](image_0.jpg) | SUITE 900 | morrison & foerster llp<br>amsterdam, austin, berlin, boston, brussels, denver, hong kong, london, los angeles, miami, new york, palo alto, san diego, san francisco, shanghai, singapore, tokyo, washington, d.c. |
| ![image_0.jpg](image_0.jpg) | WASHINGTON | morrison & foerster llp<br>amsterdam, austin, berlin, boston, brussels, denver, hong kong, london, los angeles, miami, new york, palo alto, san diego, san francisco, shanghai, singapore, tokyo, washington, d.c. |
| ![image_0.jpg](image_0.jpg) | DC 20037 | morrison & foerster llp<br>amsterdam, austin, berlin, boston, brussels, denver, hong kong, london, los angeles, miami, new york, palo alto, san diego, san francisco, shanghai, singapore, tokyo, washington, d.c. |
| ![image_0.jpg](image_0.jpg) | TELEPHONE: 202.887.1500 | morrison & foerster llp<br>amsterdam, austin, berlin, boston, brussels, denver, hong kong, london, los angeles, miami, new york, palo alto, san diego, san francisco, shanghai, singapore, tokyo, washington, d.c. |
| ![image_0.jpg](image_0.jpg) | FACSIMILE: 202.887.0763 | morrison & foerster llp<br>amsterdam, austin, berlin, boston, brussels, denver, hong kong, london, los angeles, miami, new york, palo alto, san diego, san francisco, shanghai, singapore, tokyo, washington, d.c. |
| ![image_0.jpg](image_0.jpg) | WWW.MOFO.COM | morrison & foerster llp<br>amsterdam, austin, berlin, boston, brussels, denver, hong kong, london, los angeles, miami, new york, palo alto, san diego, san francisco, shanghai, singapore, tokyo, washington, d.c. |

---

June 17, 2025

Board of Directors

Veracyte, Inc.

6000 Shoreline Court, Suite 300

South San Francisco, California, 94080

Re: <u>Registration Statement on Form S-8</u> 

Ladies and Gentlemen:

We are acting as counsel to Veracyte, Inc., a Delaware corporation (the "Company"), in connection with its registration statement on Form S-8 (the "Registration Statement"), filed with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the "Securities Act"), relating to the proposed offering of up to 2,500,000 shares (the "Shares") of the Company's common stock, par value $0.001 per share, all of which Shares may be issued pursuant to awards under the Company's 2023 Equity Incentive Plan, as amended (the "Plan").

As counsel for the Company, we have examined originals or copies, certified or otherwise identified to our satisfaction, of such documents, corporate records, certificates of public officials and other instruments as we have deemed necessary for the purposes of rendering this opinion, and we are familiar with the proceedings taken and proposed to be taken by the Company in connection with the authorization, issuance and sale of the Shares. In our examination, we have assumed the genuineness of all signatures, the authenticity of all documents submitted to us as originals and the conformity with the originals of all documents submitted to us as copies. For the purpose of the opinion rendered below, we have assumed that in connection with the issuance of the Shares, the Company will receive consideration in an amount not less than the aggregate par value of the Shares covered by each such issuance. This opinion letter is given, and all statements herein are made, in the context of the foregoing.

The opinion expressed herein is limited to the General Corporation Law of the State of Delaware, the Delaware Constitution and reported judicial decisions interpreting those laws, each as currently in effect.

Based upon and subject to the foregoing, it is our opinion that following (i) effectiveness of the Registration Statement, (ii) issuance of the Shares pursuant to the terms of the Plan, and (iii) receipt by the Company of the consideration for the Shares specified in the applicable resolutions of the Board of Directors or a duly authorized committee thereof and the Plan, the Shares will be validly issued, fully paid and nonassessable.

------

We consent to the use of this opinion as an exhibit to the Registration Statement, and we consent to the reference of our name wherever appearing in the Registration Statement and any amendments thereto. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act.

Very truly yours,

/s/ Morrison & Foerster LLP

## Exhibit 23.1

**Exhibit 23.1** 

**CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM** 

We consent to the incorporation by reference in the Registration Statement (Form S-8) pertaining to the 2023 Equity Incentive Plan of Veracyte, Inc. of our reports dated February 27, 2025, with respect to the consolidated financial statements of Veracyte, Inc. and the effectiveness of internal control over financial reporting of Veracyte, Inc. included in its Annual Report (Form 10-K) for the year ended December 31, 2024, filed with the Securities and Exchange Commission.

/s/ Ernst & Young LLP

San Diego, California

June 17, 2025

<br>