# EDGAR Filing Document

**Accession Number:** 0001757499
**File Stem:** 0001493152-25-014489
**Filing Date:** 2025-9
**Character Count:** 23587
**Document Hash:** 31683bb5f523e8d5ba4ba0b0e1ebb5d6
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001493152-25-014489.hdr.sgml**: 20250922

**ACCESSION NUMBER**: 0001493152-25-014489

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 14

**CONFORMED PERIOD OF REPORT**: 20250915

**ITEM INFORMATION**: Entry into a Material Definitive Agreement

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20250922

**DATE AS OF CHANGE**: 20250922

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Shuttle Pharmaceuticals Holdings, Inc.
- **CENTRAL INDEX KEY:** 0001757499
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-41488
- **FILM NUMBER:** 251330722

**BUSINESS ADDRESS:**
- **STREET 1:** 401 PROFESSIONAL DRIVE
- **STREET 2:** SUITE 260
- **CITY:** GAITHERSBURG
- **STATE:** MD
- **ZIP:** 20879
- **BUSINESS PHONE:** (240) 403-4212

**MAIL ADDRESS:**
- **STREET 1:** 401 PROFESSIONAL DRIVE
- **STREET 2:** SUITE 260
- **CITY:** GAITHERSBURG
- **STATE:** MD
- **ZIP:** 20879

?xml version='1.0' encoding='ASCII'?

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**FORM 8-K**

**CURRENT REPORT**

**Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934**

Date of Report (Date of earliest event reported): **September 15, 2025**

**SHUTTLE PHARMACEUTICALS HOLDINGS, INC.**

(Exact name of registrant as specified in its charter)

<u>Delaware</u> <u>001-41488</u> <u>82-5089826</u> <br> (State or other jurisdiction of incorporation) (Commission File Number) (IRS Employer Identification No.)

401 Professional Drive, Suite 260

Gaithersburg, MD 20879

(Address of principal executive offices) (Zip Code)

(240) 430-4212

(Registrant's telephone number, including area code)

N/A

(Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

---

| | | |
|:---|:---|:---|
| Title of each class | Trading Symbol(s) | Name of each exchange on which registered |
| Common Stock $0.00001 per share | SHPH | The Nasdaq Stock Market LLC |

---

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

**Item 1.01. Entry into a Material Definitive Agreement.**

On September 15, 2025, Shuttle Pharmaceuticals Holdings, Inc.(the "Company"), entered into a consulting agreement with IR Agency LLC (the "IR Agency"). Pursuant to the consulting agreement, IR Agency agreed to provide marketing and advertising services to communicate information about the Company to the financial community (the "Services"), including, but not limited to, creating company profiles, media distribution and building a digital community with respect to the Company. As consideration for the performance of the Services, the Company paid IR Agency $1,450,000. The term of the consulting agreement will be two months.

The foregoing description of the consulting agreement is qualified by reference to the full text of the consulting agreement, which is filed as Exhibit 10.1 hereto and incorporated herein by reference.

**Item 9.01 Financial Statements and Exhibits.**

(d) Exhibits

---

| | |
|:---|:---|
| Exhibit No. | Description |
| 10.1 | [Consulting Agreement, dated September 15, 2025, between Shuttle Pharmaceuticals Holdings, Inc. and IR Agency LLC.](ex10-1.htm) |
| 104 | Cover Page Interactive Data File (embedded within the Inline XBRL document) |

---

**SIGNATURES**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

---

| | | |
|:---|:---|:---|
|  | SHUTTLE PHARMACEUTICALS HOLDINGS, INC. | SHUTTLE PHARMACEUTICALS HOLDINGS, INC. |
| Dated: September 22, 2025 |  |  |
|  | By: | */s/ Christopher Cooper&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;* |
|  | Name: | Christopher Cooper |
|  | Title: | Interim Chief Executive Officer |

---

## Exhibit 10.1

**Exhibit 10.1**

![](ex10-1_001.jpg)

**<u>CONSULTING AGREEMENT</u>**

IR Agency LLC (the "Consultant" or "IR Agency") is pleased to provide certain consulting services to Shuttle Pharmaceuticals Holdings Inc ("you," "Client" or "Company") as more fully described in this agreement (the "Agreement"). This Agreement sets forth the terms and conditions pursuant to which Company engages Consultant to provide such services.

1. **Consulting Services.** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) Commencing
 on 9/11/2025 Consultant will provide marketing and advertising services ("Advertising"
 or "Services") to communicate information about the Company **(trading symbol: SHPH)** to the financial community including, but not limited to, creating company profiles,
 media distribution and building a digital community with respect to the Company.

(b) Consultant
 does not make any representation about and assumes no responsibility for the response by
 the market, if any, to the public release of Advertising for the Company. For avoidance of
 doubt, Client acknowledges that Consultant assumes no responsibility for and does not make
 any representation, guarantee or promise that in response to the public release of Advertising
 for the Company, the trading volume will increase or the trading price of **[SHPH]** will
 rise, or in the event of a increase in trading volume or rise in price, the amount or duration
 of any such increase in trading volume or rise in price

(c) Client
 acknowledges that Consultant carries no professional licenses. Consultant will not participate
 in discussions or negotiations with potential investors. Consultant will not solicit orders,
 make recommendations or give investment advice. Consultant will not effect transactions of
 securities for potential investors or anyone else. Consultant and Client agree that Consultant
 is not being engaged for, and is not permitted to engage in, activities that would give rise
 to Consultant being required to register federally or in any state or other jurisdiction
 as a broker or an investment advisor. If a financial intermediary expresses interest in the
 Company to Consultant, Consultant will refer the intermediary to the Company. In providing
 services under the Agreement, Consultant agrees to comply in all materials respects with
 all applicable U.S. securities laws. Client acknowledges and agrees that (a) it and its affiliates
 each have relied and will continue to rely on the advice of its own legal, regulatory, and
 securities law advisors for all matters and (b) neither Client nor any of its affiliates
 has received, or has relied upon, the advice of Consultant or any of its affiliates or their
 counsel regarding legal, regulatory, or securities law matters.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(d) The
 Services of Consultant shall not be exclusive to Client, and Client acknowledges that Consultant
 will be performing similar Services for other clients and Consultant shall be free to perform
 Services for such other persons.

2. **Independent Contractor.** Client and Consultant agree that Consultant shall perform its duties under
 this Agreement as an independent contractor. Nothing contained herein shall be considered
 as creating a relationship of agent-principal, employer-employee or joint venturers between
 Consultant and either Client.

3. **Compensation.** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) As
 consideration for the performance of the Services hereunder, upon the date of the execution
 and delivery of this Agreement, Client shall pay to Consultant the sum of One Million Four
 Hundred and Fifty Thousand Dollars by 9/09/2025 in cash via Bank Wire Transfer for providing
 the Services for a 2 Month term starting on 9/11/2025. Such consideration shall be deemed
 earned in full upon receipt.

(b) Unless
 otherwise provided in this Agreement, all other services, including out-of- scope assignments,
 rendered by Consultant shall be subject to additional compensation under a separate agreement
 between Consultant and Company. Consultant shall be responsible for all out-of-pocket expenses
 incurred or paid in connection with its performance of the Services hereunder.

4. **Term and Termination.** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) The
 term of this Agreement shall commence on the start date and continue for a period of 2 Months
 (the "Term") unless otherwise extended by mutual agreement of the parties (the
 "Extended Term"). This Agreement may be terminated, with or without cause, by
 either Client or Consultant at any time by written notice to the other Party. If the Agreement
 is terminated by Client during the Term for any reason, Client will not be entitled to return
 of any of the compensation. If Client files for bankruptcy, becomes insolvent or is in material
 breach of this Agreement ("Cause"), Consultant may terminate the Agreement and
 Client will not be entitled to the return of any of the compensation. If Consultant terminates
 the Agreement without Cause, then Consultant must return the unused portion (if any) of the
 Compensation. Within ten days after the termination or expiration of this Agreement, each
 party shall return to the other all Proprietary or Confidential Information (defined below)
 of the other party (and any copies thereof) in the party's possession or, with the
 approval of the other party, destroy all such Proprietary or Confidential Information.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b) In
 the event Client elects to purchase and Consultant agrees to supply additional Services during
 the Term or the Extended Term of this Agreement, the terms and condition of this Agreement
 will apply to such additional Services.

5. **Information.** 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a) In
 connection with Consultant's performance of its Services, Consultant will rely on Company's
 press releases and Company's most recent reports, if any, filed with the Securities
 and Exchange Commission (collectively, the "Company Information"). In this regard,
 Company agrees to make all filings required by the exchange act and all other applicable
 laws, in each case on a timely basis in accordance with such laws. Client hereby grants to
 Consultant the right to use the name and service marks of Company in its Services. Company

 its Services be submitted to Company for its review and approval, such approval not to be
 unreasonably withheld, conditioned or delayed.

(b) Client
 hereby acknowledges and agrees that, in performing its Services hereunder, Consultant will
 be using and relying on the Company Information without independent verification thereof.
 Consultant will also be under no obligation to determine whether there have been, or to investigate
 any changes in, such information. Consultant will be entitled to submit any materials created
 by Consultant to Company for its review and approval, such approval not to be unreasonably
 withheld, conditioned, or delayed. Client represents and warrants that that the Company Information
 and all information provided by Company or its affiliate or representatives to Consultant
 shall, at the time provided, not contain any untrue statement or material fact or omit to
 state a material fact necessary in order to make the statement made, in light of the circumstances
 under which they were made, not misleading.

(c) Client,
 by its authorization or approval of the Advertisement, represents and warrants to Consultant
 that, to its knowledge, the Advertisement is complete and correct in all material respects
 and does not contain any untrue statement of a material fact or omit to state a material
 fact necessary to make the statements therein not misleading. Client agrees to promptly notify
 Consultant upon the occurrence of any material adverse change in the business or affairs
 of the Company or upon the occurrence of any event which causes Client to believe that the
 Advertisement contains any untrue statement of a material fact or omits to state a material
 fact necessary to make the statements therein not misleading.

6. **Securities Laws.** Client represents and warrants that the Company Information and all information
 provided by Company or its affiliates or representatives complies in all respects with the
 U.S. federal and applicable state securities laws, and are not and will not be or constitute
 a part of any activity that is or may be deemed to be illegal under the U.S. federal or applicable
 state securities laws, including, without limitation, being a part of any illegal offering,
 illegal pump-and-dump, illegal scalping, illegal touting schemes, or an effort to assist
 with a violation of any court order including, but not limited to, any order banning or limiting
 a person's involvement in the securities markets.

7. **Work Product.** All information and materials produced for Client shall be the property of Consultant,
 free and clear of all claims thereto by Client, and Client shall have no claim of authorship
 therein. Consultant shall retain all right, title, and interest in and to, including any
 intellectual property rights with respect to, any data, designs, processes, specifications,
 software, applications, course, code, object code, utilities, methodologies, know-how, materials,
 information and skills (and any derivative works, modifications and enhancements thereto)
 owned, acquired or developed by or for Consultant's databases.

8. **Confidentiality.** The parties agree to hold each other's Proprietary or Confidential Information in strict
 confidence. "Proprietary or Confidential Information" shall include, but is not
 limited to, written or oral contracts, trade secrets, know-how, business methods, business
 policies, memoranda, reports, records, computer retained information, notes, or financial
 information. Proprietary or Confidential Information shall not include any information which:
 (i) is or becomes generally known to the public by any means other than a breach of the obligations
 of the receiving party; (ii) was previously known to the receiving party or rightly received
 by the receiving party from a third party; (iii) is independently developed by the receiving
 party; or (iv) is subject to disclosure under court order or other lawful process. The parties
 agree not to make each other's Proprietary or Confidential Information available in
 any form to any third party or to use each other's Proprietary or Confidential Information
 for any purpose other than as specified in this Agreement. Each party's Proprietary
 or Confidential Information shall remain the sole and exclusive property of that party. The
 parties agree that in the event of use or disclosure by the other party other than as specifically
 provided for in this Agreement, the non-disclosing party may be entitled to equitable relief.
 Notwithstanding termination or expiration of this Agreement, the parties acknowledge and
 agree that their obligations of confidentiality with respect to Proprietary or Confidential
 Information shall continue in effect for a total period of three (3) years from the termination
 date.

9. **Non** - **Public Material Information.** Consultant acknowledges that to prepare appropriate Advertising
 in a timely manner it may be made aware of price sensitive or confidential information that
 has not been publicly disclosed yet. Consultant confirms that it is fully aware of its obligations
 in relation to such information and will ensure that the confidentiality of such information
 is maintained at all times and that it, and its employees and contractors, are all fully
 aware of and comply with, all appropriate securities laws and regulations in relation to
 insider trading and related matters.

10. **Covenant Not to Sue.** Client agrees that it will not file any suit, claim, proceeding or complaint
 against Consultant arising out of or based on the failure of the trading volume of the stock
 to increase or price to rise, or to maintain any increase in trading volume or rise in stock
 price as may be occur, as a result of or in response to the public release of Advertising
 for the Company or Consultant's provision of services under this Agreement.

11. **Limitation of Liability.** Consultant shall not be liable to Client or any other person for any damages
 in connection with the provision of services under the Agreement, whether because of Consultant's
 negligence or otherwise, and regardless of the form of action, except in the event of Consultant's
 deliberate fault or gross negligence. Nevertheless, regardless of the form of action, whether
 in contract, tort or otherwise, Consultant shall not be liable to Client for any lost profits,
 business interruption, or for any indirect, incidental, special, consequential, exemplary
 or punitive damages arising out of or relating to this Agreement, nor shall Consultant's
 aggregate liability for any damages arising out of this Agreement exceed the compensation
 paid by Client to Consultant.

12. **Indemnification.** Client shall indemnify and hold Consultant harmless from and against any and all actions,
 claims, investigations (including but not limited to any formal or informal investigations
 brought by any state or federal regulator and any subpoenas or requests for documents, information
 or testimony issued in connection therewith), liabilities, losses, or damages arising from
 the preparation, presentation or dissemination of any Advertising covered by this Agreement
 including, but limited to, the costs of defense and attorneys' fees. You will also
 indemnify Consultant from and against all losses, expenses (including costs and attorneys'
 fees) and all manner of actions, claims and judgments sustained by or made against Consultant
 in connection with your use or misuse of the Service, any medium used with the Service, violation
 of this Agreement, or based upon any alleged violation of any statute, ordinance, code, or
 regulation.

13. **Notices.** Any notice or other communication required or permitted to be given to either party hereunder
 shall be in writing and shall be given to such party at such party's address set forth
 below or such other address as such party may hereafter specify by notice in writing to the
 other party. Any such notice or other communication shall be addressed as aforesaid and given
 by (a) certified mail, return receipt requested, with first class postage prepaid, (b) hand
 delivery, or (c) via electronic communication (i.e., e-mail) or (d) reputable overnight courier.
 Any notice or other communication will be deemed to have been duly given (i) on the fifth
 (5) day after mailing, provided receipt of delivery is confirmed, if mailed by certified
 mail, return receipt requested, with first class postage prepaid, (ii) on the date of Service
 if served personally or (iii) on the business day after delivery to an overnight courier
 service or by sending of an electronic communication, provided the notifying party specifies
 next day delivery and receipt of delivery has been confirmed:

If to the Client:

Email:

If to Consultant:

IR Agency LLC

23 Downing Street, Newark NJ 07105

E-mail: [Raf@ir.agency]

14. **Waiver of Breach.** Any waiver by either party of a breach of any provision of this Agreement
 by the other party shall not operate or be construed as a waiver of any subsequent breach
 by any party.

15. **Assignment.** Neither this Agreement nor any of the rights, interests or obligations hereunder may be assigned
 by either party hereto without the prior written consent of the other party, which will not
 be delayed or withheld unreasonably; provided that Client shall not be required to consent
 to any assignment by Consultant of its cash and compensation payable pursuant to this Agreement.
 Any assignment without such consent, when required, shall have no legal validity; subject
 to the foregoing, this Agreement and all of the provisions hereof will be binding upon and
 inure to the benefit of the parties to this Agreement and their respective successors and
 permitted assigns.

16. **Governing Law and Jurisdiction.** This Agreement shall be governed and construed under New Jersey
 law. The parties consent to the exclusive jurisdiction of the federal and state courts located
 in New Jersey, to hear and determine any dispute that may arise under this Agreement.

17. **Entire Agreement.** This Agreement contains the complete agreement between the parties with respect
 to the subject matter hereof and supersedes any prior proposals, understandings, agreements
 or representations by or between the parties, written or oral.

18. **Severability.** Whenever possible, each provision of this Agreement will be interpreted in such manner as
 to be effective and valid under applicable law, but if any provision of this Agreement is
 held by any court of competent jurisdiction to be prohibited by or invalid under applicable
 law, such provision will be ineffective only to the extent of such prohibition or invalidity,
 without invalidating the remainder of such provision or the remaining provisions of this
 Agreement.

19. **Waiver and Modification.** Any waiver, alteration, or modification of any of the provisions of
 this Agreement shall be valid only if made in writing through an amendment of this Agreement
 and signed by the parties hereto.

20. **Acceptance.** Please confirm that the foregoing is in accordance with Company's understanding
 by signing and returning this Agreement, which will thereupon constitute a binding Agreement
 between the Company and IR Agency, LLC as of the date of your execution. The undersigned
 officers of IR Agency, LLC and Company represent that they have the authority to bind IR
 Agency and Company, respectively. This Agreement may be executed in counterparts and with
 electronic or facsimile signatures.

---

| | |
|:---|:---|
| IR Agency LLC | IR Agency LLC |
| By: | */s/ Rafael Pereira* |
| Print Name: | Rafael Pereira |

---

---

| | |
|:---|:---|
| Shuttle Pharmaceuticals Holdings Inc. | Shuttle Pharmaceuticals Holdings Inc. |
| By: | */s/ Christopher Cooper* |
| Print Name: | Christopher Cooper, CEO |

---

Date: 9-15-2025