# EDGAR Filing Document

**Accession Number:** 0001107421
**File Stem:** 0000000000-25-010141
**Filing Date:** 2025-9
**Character Count:** 3939
**Document Hash:** 9530f51060981e5c2e6c23ccb42d6a12
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0000000000-25-010141.hdr.sgml**: 20260625

**ACCESSION NUMBER**: 0000000000-25-010141

**CONFORMED SUBMISSION TYPE**: UPLOAD

**PUBLIC DOCUMENT COUNT**: 2

**FILED AS OF DATE**: 20250917

**FILED FOR**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Alaunos Therapeutics, Inc.
- **CENTRAL INDEX KEY:** 0001107421
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 841475642
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** UPLOAD
- **SEC FILE NUMBER:** 333-289748

**BUSINESS ADDRESS:**
- **STREET 1:** 501 E LAS OLAS BLVD
- **STREET 2:** SUITE 300
- **CITY:** FORT LAUDERDALE
- **STATE:** FL
- **ZIP:** 33301
- **BUSINESS PHONE:** (346) 355-4099

**MAIL ADDRESS:**
- **STREET 1:** 501 E LAS OLAS BLVD
- **STREET 2:** SUITE 300
- **CITY:** FORT LAUDERDALE
- **STATE:** FL
- **ZIP:** 33301

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** ZIOPHARM ONCOLOGY INC
- **DATE OF NAME CHANGE:** 20050919

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** EASYWEB INC
- **DATE OF NAME CHANGE:** 20010213
**PUBLIC REFERENCE ACCESSION NUMBER**: 0001193125-25-184432

## Text-Extract

```

                                                             September 17, 2025

Holger Weis
Chief Executive Officer
Alaunos Therapeutics, Inc.
501 E. Las Olas Blvd., Suite 300
Fort Lauderdale, FL 33301

       Re: Alaunos Therapeutics, Inc.
           Amendment No. 1 to Registration Statement on Form S-3
           Filed September 9, 2025
           File No. 333-289748
Dear Holger Weis:

     We have reviewed your amended registration statement and have the
following
comment.

        Please respond to this letter by amending your registration statement
and providing
the requested information. If you do not believe a comment applies to your
facts and
circumstances or do not believe an amendment is appropriate, please tell us why
in your
response.

       After reviewing any amendment to your registration statement and the
information
you provide in response to this letter, we may have additional comments. Unless
we note
otherwise, any references to prior comments are to comments in our September 2,
2025 letter.

Amendment No. 1 to Registration Statement on Form S-3
General

1.     We note your response to prior comment 1. Specifically, we note your
statement that
       you are relying, in part, on General Instruction I.B.6 to Form S-3 to
register the resale
       of common shares that are issuable pursuant to an equity line financing
arrangement
       with Mast Hill Fund, L.P. However, given your public float and the
maximum
       principal amount of shares issuable pursuant to the equity line
financing arrangement,
       it does not appear that you are eligible to rely on General Instruction
I.B.6 to Form S-
       3 for the proposed transaction. In this regard, we note the maximum
principal amount
       of shares issuable pursuant to the equity line financing arrangement
appears to have
       exceeded one-third of your public float at the time of execution of your
Equity
       Purchase Agreement with Mast Hill Fund, L.P. Refer to Question 139.23 of
the
 September 17, 2025
Page 2

       Securities Act Sections Compliance and Disclosure Interpretations,
available on our
       website. Accordingly, please amend your registration statement as
appropriate or
       otherwise advise.
       Please contact Jason Drory at 202-551-8342 or Jessica Dickerson at
202-551-8013
with any questions.

                                                          Sincerely,

                                                          Division of
Corporation Finance
                                                          Office of Life
Sciences
cc:   Scott Doney, Esq.

```

### Attached PDF Documents

**Attachment 1:** `filename1`

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