# EDGAR Filing Document

**Accession Number:** 0001595248
**File Stem:** 0001437749-25-035207
**Filing Date:** 2025-11
**Character Count:** 27679
**Document Hash:** bbd1e6342fc1166dd7cfc25410d5f0e9
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001437749-25-035207.hdr.sgml**: 20251114

**ACCESSION NUMBER**: 0001437749-25-035207

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 15

**REFERENCES 429**: 333-237543

**REFERENCES 429**: 333-266896

**REFERENCES 429**: 333-269865

**REFERENCES 429**: 333-278758

**REFERENCES 429**: 333-284492

**FILED AS OF DATE**: 20251114

**DATE AS OF CHANGE**: 20251114

**EFFECTIVENESS DATE**: 20251114

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Genprex, Inc.
- **CENTRAL INDEX KEY:** 0001595248
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 900772347
- **STATE OF INCORPORATION:** TX
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-291548
- **FILM NUMBER:** 251487193

**BUSINESS ADDRESS:**
- **STREET 1:** 1601 TRINITY STREET, BLDG. B
- **STREET 2:** SUITE 3.322
- **CITY:** AUSTIN
- **STATE:** TX
- **ZIP:** 78712
- **BUSINESS PHONE:** 512-537-7997

**MAIL ADDRESS:**
- **STREET 1:** 1601 TRINITY STREET, BLDG. B
- **STREET 2:** SUITE 3.322
- **CITY:** AUSTIN
- **STATE:** TX
- **ZIP:** 78712

**As filed with the Securities and Exchange Commission on November 14, 2025**

**Registration No. 333-**

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**FORM S-8**

**REGISTRATION STATEMENT UNDER**

**THE SECURITIES ACT OF 1933**

**GENPREX, INC.**

(Exact name of registrant as specified in its charter)

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| | |
|:---|:---|
| **Delaware** | **90-0772347** |
| (State or other jurisdiction of<br> incorporation or organization) | (I.R.S. Employer<br> Identification Number) |

---

---

| | |
|:---|:---|
| **3300 Bee Cave Road #650-227**<br> **Austin, Texas** | **78746** |
| (Address of Principal Executive Offices) | (Zip Code) |

---

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| |
|:---|
| **Genprex, Inc. 2018 Equity Incentive Plan (As Amended and Restated Effective June 30, 2025)** |
| (Full title of the plan) |

---

---

| |
|:---|
| **Ryan M. Confer**<br> **President, Chief Executive Officer, and Chief Financial Officer**<br> **3300 Bee Cave Road #650-227**<br> **Austin, TX 78746** |
| (Name and address of agent for service) |

---

---

| |
|:---|
| **(877) 774-4679** |
| (Telephone number, including area code, of agent for service) |

---

*Copies to:*

**Kate Basmagian, Esq.**<br> **Lowenstein Sandler LLP**<br> **1251 Avenue of the Americas**<br> **New York, New York 10020**<br> **Tel: (212) 262-6700**<br>

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.

Large accelerated filer ☐ Accelerated filer ☐ <br> Non-accelerated filer ☒ Smaller reporting company ☒ <br> Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

------

**EXPLANATORY NOTE**

Pursuant to General Instruction E of Form S-8, Genprex, Inc. (the "Registrant") is filing this Registration Statement on Form S-8 (this "Registration Statement") with the Securities and Exchange Commission (the "Commission") for the purpose of registering 130,000 additional shares of the Registrant's common stock, par value $0.001 per share (the "Common Stock"), issuable under the Registrant's 2018 Equity Incentive Plan (As Amended and Restated Effective June 30, 2025) (the "Amended 2018 Plan") following the approval of the Amended 2018 Plan by the Registrant's stockholders at its annual meeting held on August 15, 2025. The 130,000 additional shares of Common Stock issuable under the Amended 2018 Plan gives effect to the 1-for-50 reverse stock split implemented on October 21, 2025 as described below.

Pursuant to General Instruction E of Form S-8, the contents of the Registration Statements on Form S-8 of the Registrant filed with the Commission on [<u>April 2, 2020</u>](http://www.sec.gov/Archives/edgar/data/0001595248/000143774920006794/gnpx20200323_s8.htm) (Registration No. 333-237543), on [<u>August 16, 2022</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774922020631/gnpx20220809_s8.htm) (Registration No. 333-266896), on [<u>February 17, 2023</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774923003784/gnpx20230214_s8.htm) (Registration No. 333-269865), on [<u>April 17, 2024</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774924012339/gnpx20240123_s8.htm) (Registration No. 333-278758), and on [<u>January 24, 2025</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774925001831/gnpx20241205_s8.htm) (Registration No. 333-284492), including any amendments thereto or filings incorporated therein, are incorporated herein by this reference to the extent not replaced or changed hereby. The shares of Common Stock registered by the foregoing Registration Statements on Form S-8 have been automatically adjusted to give effect to, in each case as appropriate, (i) the Registrant's 1-for-50 reverse stock split of the issued and outstanding shares of Common Stock effective as of 12:01 Eastern Time on October 21, 2025 and (ii) the Registrant's 1-for-40 reverse stock split of the issued and outstanding shares of Common Stock effective as of 12:01 Eastern Time on February 2, 2024.

In accordance with the instructional note to Part I of Form S-8 as promulgated by the Commission, the information specified by Part I of Form S-8 has been omitted from this Registration Statement.

------

**PART II** 

**INFORMATION REQUIRED IN THE REGISTRATION STATEMENT** 

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| | |
|:---|:---|
| **Item 3.** | **Incorporation of Documents by Reference.** |

---

The following documents, which have been filed by the Registrant with the Commission pursuant to the Securities Act of 1933, as amended (the "Securities Act") and the Securities Exchange Act of 1934, as amended (the "Exchange Act"), are incorporated herein by reference:

● The Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2024, filed with the Commission on [<u>April 1, 2025</u>](http://www.sec.gov/ix?doc=/Archives/edgar/data/1595248/000143774925010311/gnpx20241231_10k.htm) ;

● The Registrant's Quarterly Reports on Form 10-Q for the quarters ended March 31, 2025, June 30, 2025 and September 30, 2025, filed with the Commission on [<u>May 12, 2025</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774925016133/gnpx20250331_10q.htm) , [<u>August 14, 2025</u>](http://www.sec.gov/ix?doc=/Archives/edgar/data/0001595248/000143774925026965/gnpx20250630_10q.htm) and [November 14, 2025](http://www.sec.gov/Archives/edgar/data/1595248/000143774925035191/gnpx20250930_10q.htm) , respectively;

● The Registrant's Current Reports on Form 8-K filed with the Commission on [<u>January 13, 2025</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774925000932/gnpx20250105_8k.htm) ; [<u>January 23, 2025</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774925001630/gnpx20241220_8k.htm) ; [<u>February 12, 2025</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774925003490/gnpx20250203_8k.htm) ; [<u>February 18, 2025</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774925004126/gnpx20241220c_8k.htm) ; [<u>April 28, 2025</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774925013235/gnpx20250424_8k.htm) ; [<u>May 6, 2025</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774925014618/gnpx20250428_8k.htm) ; [<u>May 7, 2025</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774925014909/gnpx20250506_8k.htm) ; [<u>June 9, 2025</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774925019767/gnpx20250606_8k.htm) ; [<u>June 11, 2025</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774925020102/gnpx20250606c_8k.htm) , [<u>June 23, 2025</u>](http://www.sec.gov/ix?doc=/Archives/edgar/data/0001595248/000143774925020977/gnpx20250618_8k.htm) , [<u>June 24, 2025</u>](http://www.sec.gov/ix?doc=/Archives/edgar/data/0001595248/000143774925021093/gnpx20250618c_8k.htm) , [<u>August 15, 2025</u>](http://www.sec.gov/ix?doc=/Archives/edgar/data/0001595248/000143774925027138/gnpx20250708c_8k.htm) , [<u>August 18, 2025</u>](http://www.sec.gov/ix?doc=/Archives/edgar/data/0001595248/000143774925027191/gnpx20250815_8k.htm) , [<u>August 20, 2025</u>](http://www.sec.gov/ix?doc=/Archives/edgar/data/0001595248/000143774925027451/gnpx20250818_8k.htm) , [<u>October 17, 2025</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774925031210/gnpx20251001_8k.htm) , [<u>October 21, 2025</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774925031382/gnpx20251021c_8k.htm) , [<u>October 23, 2025</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774925031572/gnpx20251021d_8k.htm) , [<u>October 24, 2025</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774925031678/gnpx20251021_8k.htm) , [<u>October 28, 2025</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774925031856/gnpx20251024c_8k.htm) , [<u>October 29, 2025</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774925032081/gnpx20251028_8k.htm) , and [<u>November 4, 2025</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774925032870/gnpx20251024_8k.htm) (other than any portions thereof deemed furnished and not filed);

● The Registrant's Definitive Proxy Statement on Schedule 14A filed with the Commission on [<u>July 16, 2025</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774925022834/gnpx20250707_def14a.htm) ; and

● The description of the Registrant's Common Stock contained in the Registrant's Registration Statement on Form 8-A, filed with the Commission on [<u>October 13, 2017</u>](http://www.sec.gov/Archives/edgar/data/1595248/000119312517309662/d454099d8a12b.htm) , as updated by the Description of Registrant's Securities set forth on [<u>Exhibit 4.20</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774925010311/ex_727457.htm) to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2024, filed with the Commission on April 1, 2025, and any amendments thereto or reports filed for the purposes of updating such description.

All documents filed by the Registrant pursuant to Section 13(a), 13(c), 14 and 15(d) of the Exchange Act subsequent to the filing of this Registration Statement and prior to the filing of a post-effective amendment, which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference into this Registration Statement and to be a part hereof from the date of filing such documents, except as to specific sections of such documents as set forth therein; provided, however, that documents or information deemed to have been furnished and not filed in accordance with Commission rules shall not be deemed incorporated by reference into this Registration Statement. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained in any subsequently filed document, which also is deemed to be incorporated by reference herein, modifies or supersedes such statement.

------

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| | |
|:---|:---|
| **Item 8.** | **Exhibits** |

---

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| | |
|:---|:---|
| **Exhibit**<br> **Number** | **Description of Exhibit** |
| 3.1 | [Amended and Restated Certificate of Incorporation of the Registrant, dated April 3, 2018, incorporated by reference to Exhibit 3.1 of the Registrant's Current Report on Form 8-K filed on April 10, 2018.](http://www.sec.gov/Archives/edgar/data/1595248/000118518518000666/ex3-1.htm) |
| 3.2 | [<u>Certificate of Amendment of the Amended and Restated Certificate of Incorporation, dated January 31, 2024, incorporated by reference to Exhibit 3.1 of the Registrant'</u><u>s Current Report on Form 8-K filed on January 31, 2024.</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774924002620/ex_618362.htm) |
| 3.3 | [<u>Certificate of Amendment of the Amended and Restated Certificate of Incorporation of Genprex, Inc., dated October 16, 2025, incorporated by reference to Exhibit 3.1 of the Registrant'</u><u>s Current Report on Form 8-K, filed on October 17, 2025.</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774925031210/ex_865723.htm) |
| 3.4 | [Amended and Restated Bylaws of the Registrant, dated April 3, 2018, incorporated by reference to Exhibit 3.2 of the Registrant's Current Report on Form 8-K filed on April 10, 2018.](http://www.sec.gov/Archives/edgar/data/1595248/000118518518000666/ex3-2.htm) |
| 3.5 | [<u>Amendment No. 1 adopted and approved by the Registrant'</u><u>s Board of Directors on October 18, 2023, incorporated by reference to Exhibit 3.1 of the Registrant</u><u>'</u><u>s Current Report on Form 8-K filed on October 23, 2023.</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774923028769/ex_582314.htm) |
| 3.6 | [Amendment No. 2 adopted and approved by Registrant's Board of Directors on March 29, 2025, incorporated by reference to Exhibit 3.5 of the Registrant's Annual Report on Form 10-K filed on April 1, 2025.](http://www.sec.gov/Archives/edgar/data/1595248/000143774925010311/ex_788396.htm) |
| 4.1 | [Form of Common Stock Certificate of the Registrant (incorporated by reference to Exhibit 4.1 to the Registrant's Registration Statement on Form S-1 (File No. 333-219386), as amended, originally filed on July 21, 2017).](http://www.sec.gov/Archives/edgar/data/1595248/000119312517286120/d415543dex41.htm) |
| 5.1\* | [Opinion of Lowenstein Sandler LLP.](ex_886523.htm) |
| 10.1 | [Genprex, Inc. 2018 Equity Incentive Plan (As Amended and Restated Effective June 30, 2025), incorporated by reference to Exhibit 10.1 of the Registrant's Current Report on Form 8-K filed on August 15, 2025.](http://www.sec.gov/Archives/edgar/data/1595248/000143774925027138/ex_837023.htm) |
| 10.2 | [Form of Notice of Stock Option Grant and Stock Option Agreement, incorporated by reference to Exhibit 10.3 to the Registrant's Annual Report on Form 10-K for the fiscal year ended December 31, 2023 filed on April 1, 2024.](http://www.sec.gov/Archives/edgar/data/1595248/000143774924010426/ex_637850.htm) |
| 10.3 | [Form of Notice of Restricted Stock Award and Restricted Stock Agreement, incorporated by reference to Exhibit 10.3 to the Registrant<u>'</u><u>s Annual Report on Form 10-K for the fiscal year ended December 31, 2023 filed on April 1, 2024.</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774924010426/ex_637850.htm) |
| 10.4 | [Form of Notice of Restricted Stock Unit Award and Restricted Stock Unit Agreement, incorporated by reference to Exhibit 10.3 to the Registrant<u>'</u><u>s Annual Report on Form 10-K for the fiscal year ended December 31, 2023 filed on April 1, 2024.</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774924010426/ex_637850.htm) |
| 10.5 | [Form of Employee Stock Option Grant Notice and Option Agreement, incorporated by reference to Exhibit 10.3 to the Registrant<u>'</u><u>s Annual Report on Form 10-K for the fiscal year ended December 31, 2023 filed on April 1, 2024.</u>](http://www.sec.gov/Archives/edgar/data/1595248/000143774924010426/ex_637850.htm) |
| 23.1\* | [Consent of WithumSmith+Brown, PC, Independent Registered Public Accounting Firm.](ex_886524.htm) |
| 23.2\* | [Consent of Lowenstein Sandler LLP (included in Exhibit 5.1).](ex_886523.htm) |
| 24.1\* | [Power of Attorney (included on the signature page to this Registration Statement on Form S-8).](#poa) |
| 107\* | [Filing Fee Table.](ex_886526.htm) |

---

\* Filed herewith.

------

**SIGNATURES**

Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Austin, State of Texas, on November 14, 2025.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; GENPREX, INC.<br>By: <u>/s/ Ryan M. Confer</u><br> Name: Ryan M. Confer<br> Title: President*,* Chief Executive Officer and Chief Financial Officer<br>

 

**POWER OF ATTORNEY**

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Ryan Confer as his true and lawful attorney-in-fact and agent with the full power of substitution, for him in any and all capacities, to sign any and all amendments to this Registration Statement, including any and all post-effective amendments, and to file such amendments thereto, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he might or could do in person, hereby ratifying and confirming that said attorney-in-fact and agent, or his substitute, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated.

---

| | | |
|:---|:---|:---|
| <u>Signature</u> | <u>Title</u> | <u>Date</u> |
| <br> <u>/s/ Ryan M. Confer</u><br> Ryan M. Confer | <br> President, Chief Executive Officer, Chief Financial Officer and Director<br> *(Principal Executive Officer and Principal Financial and Accounting Officer)* | <br> November 14, 2025 |
| <u>/s/ Brent M. Longnecker</u><br> Brent M. Longnecker | Director | November 14, 2025 |
| <u>/s/ Jose Antonio Moreno Toscano</u><br> Jose Antonio Moreno Toscano | Chairman of the Board | November 14, 2025 |
| <u>/s/ Will R. Wilson, Jr.</u><br> Will R. Wilson, Jr. | Director | November 14, 2025 |

---

## Exhibit 5.1

**Exhibit 5.1**

![lslogo.jpg](lslogo.jpg)

November 14, 2025

Genprex, Inc.

3300 Bee Cave Road #650-227

Austin, Texas 78746

**Re: Registration Statement on Form S-8**

Ladies and Gentlemen:

We have acted as counsel for Genprex, Inc., a Delaware corporation (the "Company"), in connection with the Company's filing on the date hereof with the U.S. Securities and Exchange Commission (the "Commission") of a Registration Statement on Form S-8 (the "Registration Statement") under the Securities Act of 1933, as amended (the "Securities Act"). The Registration Statement relates to the registration of 130,000 shares (the "Shares") of the Company's common stock, par value $0.001 per share (the "Common Stock"), issuable pursuant to the Genprex, Inc. 2018 Equity Incentive Plan (As Amended and Restated Effective June 30, 2025) (the "Plan").

In connection with rendering this opinion, we have examined or are familiar with: (i) the Amended and Restated Certificate of Incorporation of the Company, as amended (the "Amended and Restated Certificate"); (ii) the Amended and Restated Bylaws of the Company, as amended; (iii) the Plan; (iv) the corporate proceedings with respect to the authorization of the Registration Statement; and (v) such other corporate records, agreements, documents and other instruments, and such certificates or comparable documents of public officials and of officers and representatives of the Company, and have made such inquiries of such officers and representatives, as we have deemed relevant and necessary or appropriate for purposes of this opinion.

In such examination, we have assumed the genuineness of all signatures, the authenticity of all documents submitted to us as originals, the conformity to the original documents of all documents submitted to us as copies and the authenticity of the originals of such latter documents. As to any facts material to our opinion, we have, when relevant facts were not independently established, relied upon certificates or comparable documents of officers and representatives of the Company.

Based upon the foregoing, and subject to the qualifications stated herein, we are of the opinion that the Shares being registered pursuant to the Registration Statement, upon issuance and delivery in accordance with the terms of the Plan, will be validly issued, fully paid and non-assessable.

The opinion expressed herein is limited to the General Corporation Law of the State of Delaware (including the statutory provisions, all applicable provisions of the Delaware Constitution and reported judicial decisions interpreting the foregoing) and we express no opinion as to the effect on the matters covered by this letter of the laws of any other jurisdiction. We assume no obligation to advise you of facts or circumstances that come to our attention or changes in law that occur which could affect the opinions contained herein.

We hereby consent to the filing of a copy of this letter as an exhibit to the Registration Statement. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act, or the rules and regulations of the Commission promulgated thereunder.

---

| | |
|:---|:---|
| Very truly yours, | Very truly yours, |
| By: | */s/ Lowenstein Sandler LLP* |
|  | Lowenstein Sandler LLP |

---

## Exhibit 23.1

**Exhibit 23.1**

**CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM**

Genprex, Inc.

Austin, Texas

We hereby consent to the incorporation by reference in this Registration Statement on Form S-8 of Genprex, Inc. (the "Company") of our report dated March 31, 2025 (which includes an explanatory paragraph relating to the Company's ability to continue as a going concern) relating to the financial statements of the Company as of and for the years ended December 31, 2024 and 2023, appearing in the Company's Annual Report on Form 10-K for the year ended December 31, 2024 filed with the Securities and Exchange Commission on April 1, 2025.

*/s/ WithumSmith+Brown, PC*

East Brunswick, New Jersey

November 14, 2025

## Ex-Filing

?xml version='1.0' encoding='ASCII'? EX-FILING FEES

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| |
|:---|
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Calculation of Filing Fee Tables**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **S-8**  |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Genprex, Inc.**  |

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| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Security Type**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Security Class Title**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Fee Calculation Rule**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Amount Registered**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Proposed Maximum Offering Price Per Unit**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Maximum Aggregate Offering Price**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Fee Rate**  | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Amount of Registration Fee**  |
| 1 | Equity | Common stock, $0.001 par value per share | Other | 130000 | $3.985 | $518050.00 | 0.0001381 | $71.54 |
| Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: |  | $518050.00  |  | $71.54  |
| Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  |  |  |  | $0.00  |
| Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  |  |  |  | $71.54  |

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; **Offering Note** <br>

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <sup>1</sup> (1) Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement shall also cover any additional shares of the Registrant's common stock that become issuable under the Registrant's 2018 Equity Incentive Plan (As Amended and Restated Effective June 30, 2025) (the "Amended 2018 Plan") in respect of the securities identified in the above table by reason of any stock dividend, stock split, recapitalization, antidilution provisions, or other similar transactions. (2) Represents 130,000 additional shares of the Registrant's common stock issuable under the Amended 2018 Plan following the approval of the Amended 2018 Plan by the Registrant's stockholders at its annual meeting held on August 15, 2025. (3) Estimated pursuant to Rule 457(c) and Rule 457(h) of the Securities Act solely for purposes of calculating the registration fee. The offering price per share and the aggregate offering price for shares reserved for future issuance under the Amended 2018 Plan are based on the average of the high and the low price of the Registrant's common stock as reported on the Nasdaq Capital Market on November 11, 2025, which date is within five business days prior to filing this Registration Statement. (4) The Registrant does not have any fee offsets.

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| | |
|:---|:---|
| | |
| **Rule 457(p)** | **Rule 457(p)** |
| Fee Offset Claims | N/A |
| Fee Offset Sources | N/A |

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