# EDGAR Filing Document

**Accession Number:** 0001574232
**File Stem:** 0001104659-25-060772
**Filing Date:** 2025-6
**Character Count:** 116958
**Document Hash:** 48cc4153042269611c7b5b6b9334fa30
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-25-060772.hdr.sgml**: 20250620

**ACCESSION NUMBER**: 0001104659-25-060772

**CONFORMED SUBMISSION TYPE**: 6-K

**PUBLIC DOCUMENT COUNT**: 5

**CONFORMED PERIOD OF REPORT**: 20250620

**FILED AS OF DATE**: 20250620

**DATE AS OF CHANGE**: 20250620

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Addex Therapeutics Ltd.
- **CENTRAL INDEX KEY:** 0001574232
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** V8
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 6-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-39179
- **FILM NUMBER:** 251058908

**BUSINESS ADDRESS:**
- **STREET 1:** CHEMIN DES MINES 9
- **CITY:** GENEVA
- **STATE:** V8
- **ZIP:** CH-1202
- **BUSINESS PHONE:** 01141228841555

**MAIL ADDRESS:**
- **STREET 1:** CHEMIN DES MINES 9
- **CITY:** GENEVA
- **STATE:** V8
- **ZIP:** CH-1202

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**FORM 6-K**

**REPORT OF FOREIGN PRIVATE ISSUER** 

**PURSUANT TO RULE 13a-16 OR 15d-16**

**UNDER THE SECURITIES EXCHANGE ACT OF 1934**

**June 2025**

**Commission File Number: 001-39179**

**Addex Therapeutics Ltd**

(Exact Name of Registrant as Specified in Its Charter)

**Chemin des Mines 9,<br> CH-1202 Geneva, Switzerland**

(Address of principal executive offices)

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.

Form 20-F ⌧ Form 40-F □

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1): □

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7): □

**INCORPORATION BY REFERENCE**

Exhibits 99.1 and 99.2 to this Report on Form 6-K shall be deemed to be incorporated by reference into the registration statement on Form F-3 (Registration No. 333-255089) of Addex Therapeutics Ltd and the registration statement on Form S-8 (Registration No. 333-255124 and No. 333-272515) of Addex Therapeutics Ltd (including any prospectuses forming a part of such registration statements) and to be a part thereof from the date on which this report is filed, to the extent not superseded by documents or reports subsequently filed or furnished.

**RISK FACTORS**

Our business faces significant risks. You should carefully consider all of the information set forth in this Report on Form 6-K and in our other filings with the United States Securities and Exchange Commission, or the SEC, including the risk factors related to our business set forth in our Annual Report on Form 20-F for the year ended December 31, 2024 filed with the Securities and Exchange Commission on May 15, 2025. Our business, financial condition, results of operations and growth prospects could be materially adversely affected by any of these risks. This report also contains forward-looking statements that involve risks and uncertainties. Our results could materially differ from those anticipated in these forward-looking statements, as a result of certain factors including the risks described in our Annual Report and our other SEC filings.

SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

---

| | | | |
|:---|:---|:---|:---|
|  | **Addex Therapeutics Ltd** | **Addex Therapeutics Ltd** | **Addex Therapeutics Ltd** |
|  | By: | /s/ Tim Dyer | /s/ Tim Dyer |
|  |  | Name: | Tim Dyer |
| Date: June 20, 2025 |  | Title: | Chief Executive Officer |

---

**EXHIBIT INDEX**

---

| | |
|:---|:---|
| **Exhibit<br> No.** | **Description** |
| [Exhibit 99.1 :](tm2518303d1_ex99-1.htm) | [Unaudited Interim Condensed Consolidated Financial Statements](tm2518303d1_ex99-1.htm) |
| [Exhibit 99.2 :](tm2518303d1_ex99-2.htm) | [Management's Discussion and Analysis of Financial Condition and Result of Operations](tm2518303d1_ex99-2.htm) |
| [Exhibit 99.3 :](tm2518303d1_ex99-3.htm) | [Press Release dated June 19, 2025](tm2518303d1_ex99-3.htm) |

---

## Exhibit 99.1

**Exhibit 99.1**

**ADDEX THERAPEUTICS LTD**

**INDEX TO UNAUDITED INTERIM CONDENSED CONSOLIDATED FINANCIAL STATEMENTS**

---

| | |
|:---|:---|
| **Unaudited Interim Condensed Consolidated Financial Statements** |  |
| Unaudited Interim Condensed Consolidated Balance Sheets as of March 31, 2025 and December 31, 2024 | 2 |
| Unaudited Interim Condensed Consolidated Statements of Comprehensive Loss for the three-month periods ended March 31, 2025 and 2024 | 3 |
| Unaudited Interim Condensed Consolidated Statements of Changes in Equity for the three-month periods ended March 31, 2025 and 2024 | 4 |
| Unaudited Interim Condensed Consolidated Statements of Cash Flows for the three-month periods ended March 31, 2025 and 2024 | 5 |
| Unaudited Notes to the Interim Condensed Consolidated Financial Statements for the three-month period ended March 31, 2025 | 6 |

---

**Addex Therapeutics** │ **Unaudited Interim Condensed Consolidated Financial Statements**

**Unaudited Interim Condensed Consolidated Balance Sheets**

**as of March 31, 2025, and December 31, 2024**

---

| | | | |
|:---|:---|:---|:---|
|  | **Notes** | **March 31,<br> 2025** | **December 31,<br> 2024** |
|  |  | **Amounts in Swiss francs** | **Amounts in Swiss francs** |
| **ASSETS** |  |  |  |
| **Current assets** |  |  |  |
| Cash and cash equivalents | 6 | 2825484 | 3341738 |
| Other financial assets | 7/13 | 6828 | 6496 |
| Trade and other receivables | 7 | 35361 | 15513 |
| Prepayments | 7 | 329605 | 169649 |
| Other current assets |  | - | 7967 |
| **Total current assets** |  | **3197278** | **3541363** |
| **Non-current assets** |  |  |  |
| Right-of-use assets | 8 | 39567 | 41578 |
| Intangible assets | 10 |  |  |
| Equipment | 9 | 1024 | 1131 |
| Non-current financial assets | 11 | 7094 | 7089 |
| Investment accounted for using the equity method | 22 | 6239691 | 7087142 |
| **Total non-current assets** |  | **6287376** | **7136940** |
| **Total assets** |  | **9484654** | **10678303** |
| **LIABILITIES AND EQUITY** |  |  |  |
| **Current liabilities** |  |  |  |
| Current lease liabilities |  | 7398 | 7306 |
| Payables and accruals | 12 | 948171 | 794787 |
| Other current liabilities | 12 | 101243 | - |
| **Total current liabilities** |  | **1056812** | **802093** |
| **Non-current liabilities** |  |  |  |
| Non-current lease liabilities |  | 32804 | 34688 |
| Retirement benefits obligations | 15 | 99360 | 164251 |
| **Total non-current liabilities** |  | **132164** | **198939** |
| **Equity** |  |  |  |
| Share capital | 13 | 1843545 | 1843545 |
| Share premium | 13 | 266382595 | 266382670 |
| Other equity | 13 | 64620223 | 64620223 |
| Treasury shares reserve | 13 | (869302) | (869708) |
| Other reserves |  | 31153935 | 31062996 |
| Accumulated deficit |  | (354835318) | (353362455) |
| **Total equity** |  | **8295678** | **9677271** |
| **Total liabilities and equity** |  | **9484654** | **10678303** |

---

The accompanying notes form an integral part of these consolidated financial statements.

**Addex Therapeutics** │ **Unaudited Interim Condensed Consolidated Financial Statements**

**Unaudited Interim Condensed Consolidated Statements of Comprehensive Loss**

**for the three-month period ended March 31, 2025 and 2024**

---

| | | | |
|:---|:---|:---|:---|
|  | | **For the three months ended<br> March 31,** | **For the three months ended<br> March 31,** |
|  | <br>**Notes** | **2025** | **2024** |
|  |  | **Amounts in Swiss francs** | **Amounts in Swiss francs** |
| **Revenue from contract with customer** | 16 | **-** | **233480** |
| **Other income** | 17 | **71055** | **1430** |
| **Operating costs** |  |  |  |
| Research and development |  | (156066) | (245125) |
| General and administration |  | (521251) | (777877) |
| **Total operating costs** | 18 | **(677317)** | **(1023002)** |
| **Operating loss** |  | **(606262)** | **(788092)** |
| Finance income |  |  | 53525 |
| Finance expense |  | (19150) | (611) |
| **Finance result** | 20 | **(19150)** | **52914** |
| Share of net loss of investment accounted for using the equity method | 22 | (847451) | **-** |
| **Net loss before tax from continuing operations** |  | **(1472863)** | **(735178)** |
| Income tax expense |  | **-** | - |
| **Net loss from continuing operations** |  | **(1472863)** | **(735178)** |
| Net loss from discontinued operations (attributable to equity holders of the Group) | 21 |  | (2351961) |
| **Net loss for the period** |  | **(1472863)** | **(3087139)** |
| **Basic and diluted loss per share** |  |  |  |
| From continuing operations |  | (0.01) | (0.01) |
| From discontinued operations |  |  | (0.02) |
| **Total basic and diluted loss per share for loss attributable to the ordinary equity holders of the Company** | 23 | **(0.01)** | **(0.03)** |
| **Other comprehensive income / (loss)** |  |  |  |
| Items that will never be reclassified to profit and loss: |  |  |  |
| Remeasurements of retirement benefits obligation related to continuing operations |  | 65892 | (2497) |
| Remeasurements of retirement benefits obligation related to discontinued operations |  |  | (47348) |
| Items that may be classified subsequently to profit and loss: |  |  |  |
| Exchange difference on translation of foreign operations |  | 130 | 1128 |
| **Other comprehensive income / (loss) for the period, net of tax** |  | **66022** | **(48717)** |
| **Total comprehensive loss for the period** |  | **(1406841)** | **(3135856)** |
| From continuing operations |  | (1406841) | (736547) |
| From discontinued operations |  |  | (2399309) |

---

The accompanying notes form an integral part of these consolidated financial statements.

**Addex Therapeutics** │ **Unaudited Interim Condensed Consolidated Financial Statements**

**Unaudited Interim Condensed Consolidated Statements of Changes in Equity**

**for the three-month periods ended March 31, 2025 and 2024**

---

| | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
|  | **Notes** | **Share<br> Capital** | **Share<br> Premium** | **Other<br> Equity** | **Treasury<br> Shares<br> Reserve** | **Foreign<br> Currency<br> Translation<br> Reserve** | **Other<br> Reserves** | **Accumulated<br> Deficit** | **Total** |
| **Amounts in Swiss francs** | **Amounts in Swiss francs** | **Amounts in Swiss francs** | **Amounts in Swiss francs** | **Amounts in Swiss francs** | **Amounts in Swiss francs** | **Amounts in Swiss francs** | **Amounts in Swiss francs** | **Amounts in Swiss francs** | **Amounts in Swiss francs** |
| **Balance as of January 1, 2024** |  | **1843545** | **266194689** | **64620223** | **(909566)** | **(659870)** | **30474686** | **(360418242)** | **1145465** |
| Net loss for the period |  |  |  |  |  |  |  | (3087139) | (3087139) |
| Other comprehensive loss for the period |  | **-** | **-** | **-** | - | 1128 | (49845) | - | (48717) |
| **Total comprehensive loss for the period** |  | **-** | **-** | **-** | **-** | **1128** | **(49845)** | **(3087139)** | **(3135856)** |
| Cost of pre-funded warrants exercised |  |  | (3647) |  |  |  |  |  | (3647) |
| Value of share-based services | 14 |  | **-** |  |  |  | 386028 |  | 386028 |
| Movement in treasury shares: | 13 |  |  |  |  |  |  |  |  |
| Net sales under liquidity agreement |  |  | (2417) |  | 3947 | . |  |  | 1530 |
| Sales agency agreement |  | **-** | 204750 |  | 30507 |  |  |  | 235257 |
| Costs under sale agency agreement |  | **-** | (1764) | - | - | - | - | - | (1764) |
| **Balance as of March 31, 2024** |  | **1843545** | **266391611** | **64620223** | **(875112)** | **(658742)** | **30810869** | **(363505381)** | **(1372987)** |

---

---

| | | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|:---|
|  | **Notes** | **Share<br> Capital** | **Share<br> Premium** | **Other<br> Equity** | **Treasury<br> Shares<br> Reserve** | **Foreign<br> Currency<br> Translation<br> Reserve** | **Other<br> Reserves** | **Accumulated<br> Deficit** | **Total** |
| **Amounts in Swiss francs** | **Amounts in Swiss francs** | **Amounts in Swiss francs** | **Amounts in Swiss francs** | **Amounts in Swiss francs** | **Amounts in Swiss francs** | **Amounts in Swiss francs** | **Amounts in Swiss francs** | **Amounts in Swiss francs** | **Amounts in Swiss francs** |
| **Balance as of January 1, 2025** |  | **1843545** | **266382670** | **64620223** | **(869708)** | **(658885)** | **31721881** | **(353362455)** | **9677271** |
| Net loss for the period |  |  |  |  |  |  |  | (1472863) | (1472863) |
| Other comprehensive Income for the period. |  | - | - | - | - | 130 | 65892 | - | 66022 |
| **Total comprehensive loss for the period** |  | **-** | **-** | **-** | **-** | **130** | **65892** | **(1472863)** | **(1406841)** |
| Value of share-based services | 14 |  |  |  |  |  | 24917 |  | 24917 |
| Net sales of treasury shares under liquidity agreement | 13 | - | (75) | - | 406 | - | - | - | 331 |
| **Balance as of March 31, 2025** |  | **1843545** | **266382595** | **64620223** | **(869302)** | **(658755)** | **31812690** | **(354835318)** | **8295678** |

---

The accompanying notes form an integral part of these consolidated financial statements.

**Addex Therapeutics** │ **Unaudited Interim Condensed Consolidated Financial Statements**

**Unaudited Interim Condensed Consolidated Statements of Cash Flows**

**for the three-month periods ended March 31, 2025 and 2024**

---

| | | | |
|:---|:---|:---|:---|
|  | | **For the three months ended<br> March 31,** | **For the three months ended<br> March 31,** |
|  | <br>**Notes** | **2025** | **2024** |
|  |  | **Amounts in Swiss francs** | **Amounts in Swiss francs** |
| **Net loss for the period** |  | **(1472863)** | **(3087139)** |
| Adjustments for: |  |  |  |
| &nbsp;&nbsp;&nbsp;Depreciation | 8/9 | 2118 | 70360 |
| &nbsp;&nbsp;&nbsp;Fair value of services received at zero cost recorded as other income.. | 10 | (71055) |  |
| &nbsp;&nbsp;&nbsp;Fair value of services received at zero cost recorded as other operating costs | 10 | 71055 |  |
| &nbsp;&nbsp;&nbsp;Value of share-based services | 14 | 24917 | 386028 |
| &nbsp;&nbsp;&nbsp;Post-employment benefits |  | 1003 | (28327) |
| &nbsp;&nbsp;&nbsp;Share of the net loss of associates | 22 | 847451 |  |
| &nbsp;&nbsp;&nbsp;Finance cost / (income) net |  | 16087 | (98152) |
| Increase in other financial assets | 7 | (332) | (1532) |
| Increase in trade and other receivables | 7 | (19848) | (5885) |
| Increase in contract asset | 7 |  | (67894) |
| Increase in prepayments | 7 | (159833) | (434559) |
| Decrease in other current assets | 7 | 7967 |  |
| Increase in payables and accruals | 12 | 153384 | 931159 |
| Increase in other current liabilities | 12 | 1243 |  |
| Decrease in deferred income |  |  | (324210) |
| Assets recorded as held for sale | 21 |  | (186522) |
| Liabilities recorded as held for sale | 21 | - | 652294 |
| **Net cash used in operating activities** |  | **(598706)** | **(2194379)** |
| **Cash flows from financing activities** |  |  |  |
| Costs paid on sale of treasury shares – shelf registration |  |  | (2782) |
| Costs paid on exercise of pre-funded warrants |  |  | (2230) |
| Sales under sale agency agreement & liquidity agreement movements | 13 | 331 | 236787 |
| Costs paid on sale of treasury shares under sale agency agreement |  |  | (1764) |
| Funds received in advance for future sales of treasury shares | 12 | 100000 |  |
| Principal element of lease payment |  | (1792) | (66735) |
| Interest received | 20 |  | 7555 |
| Interest paid | 20 | (548) | (6283) |
| **Net cash from financing activities** |  | **97991** | **164548** |
| **Decrease in cash and cash equivalents** |  | **(500715)** | **(2029831)** |
| Cash and cash equivalents at the beginning of the period | 6 | 3341738 | 3865481 |
| Asset recorded as held for sale (cash) | 21 |  | (305809) |
| Exchange difference on cash and cash equivalents |  | (15539) | 97991 |
| **Cash and cash equivalents at the end of the period** | 6 | **2825484** | **1627832** |

---

During the three-month period ended March 31, 2025 non-cash items of CHF 0.9 million primarily relate to the share of the net loss of associates (note 22).

The accompanying notes form an integral part of these consolidated financial statements.

**Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes** 

**Unaudited Notes to the Interim Condensed Consolidated Financial Statements**

**for the three-month period ended March 31, 2025**

**(Amounts in Swiss francs)**

**1. General information**

Addex Therapeutics Ltd (the "Company") and its subsidiaries (together, the "Group") are a clinical stage biopharmaceutical company focused on developing a portfolio of novel small molecule allosteric modulators for neurological disorders.

The Company is a Swiss stockholding corporation domiciled c/o Addex Pharma SA, Chemin des Aulx 12, CH 1228 Plan-les-Ouates, Geneva, Switzerland and the parent company of Addex Pharma SA, Addex Pharmaceuticals France SAS and Addex Pharmaceuticals Inc. Addex Therapeutics also owns a 20% equity interest in Neurosterix US Holdings LLC, USA. Neurosterix US Holdings LLC fully owns directly Neurosterix Swiss Holdings AG, Switzerland and indirectly Neurosterix Pharma Sàrl whose principal place of business is Chemin des Mines 9, CH 1202 Geneva, Switzerland.

The Groups principal place of business is Chemin des Mines 9, CH 1202 Geneva, Switzerland. Its registered shares are traded at the SIX Swiss Exchange, under the ticker symbol ADXN and its American Depositary Shares (ADSs) on the Nasdaq Stock Market under the symbol ADXN. ADSs represents shares that continue to be admitted to trading on SIX Swiss Exchange.

These interim condensed consolidated financial statements have been approved for issuance by the Board of Directors on June 18, 2025.

**2. Basis of preparation**

These interim condensed consolidated financial statements for the three-month period ended March 31, 2025, have been prepared under the historic cost convention and in accordance with IAS 34 "Interim Financial Reporting" and are presented in a format consistent with the consolidated financial statements under IAS 1 "Presentation of Financial Statements". However, they do not include all of the notes that would be required in a complete set of financial statements. Thus, this interim financial report should be read in conjunction with the consolidated financial statements for the year ended December 31, 2024.

Interim financial results are not necessarily indicative of results anticipated for the full year. The preparation of these unaudited interim condensed consolidated financial statements made in accordance with IAS 34 requires the use of estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Although these estimates are based on management's best knowledge of current events and actions, actual results ultimately may differ from those estimates. The areas involving a higher degree of judgment which are significant to the interim condensed consolidated financial statements are disclosed in note 4 to the consolidated financial statements for the year ended December 31, 2024.

A number of new or amended standards and interpretations became applicable for financial reporting periods beginning on or after January 1, 2025. Of the latter, the Group noted the amendment of IAS 21: The Effects of Changes in Foreign Exchange rates relating to the exchange rate of currencies that are not exchangeable. The Group concluded that this amendment was not relevant as the Group only uses major currencies. The Group is also assessing other new and revised standards which are not mandatory until after 2025 and noted that IFRS 18 – Presentation and Disclosure in Financial Statements will replace IAS 1 - Presentation of Financial Statements - from January 1, 2027 and may impact the presentation and structure of the Group's primary financial statements and related disclosures.

Due to rounding, numbers presented throughout these interim condensed consolidated financial statements may not add up precisely to the totals provided. All ratios and variances are calculated using the underlying amounts rather than the presented rounded amounts. Where necessary, comparative figures have been revised to conform with the current year 2025.

**Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes** 

**3. Material accounting estimates and judgments**

The Group makes estimates and assumptions concerning the future. These estimates and judgments are continually evaluated and are based on historical experience and other factors, including expectations of future events that are believed to be reasonable under the circumstances. The resulting accounting estimates will, by definition, seldom equal the related actual results. The estimates and assumptions that have a significant risk of causing a material adjustment to the carrying amounts of assets and liabilities or may have had a significant impact on the reported results are disclosed below:

*Going concern*

The Group's accounts are prepared on a going concern basis. To date, the Group has financed its cash requirements primarily from share issuances, licensing certain of its research and development stage products and selling its allosteric modulator drug discovery technology platform with a portfolio of preclinical programs. The Group is a development-stage enterprise and is exposed to all the risks inherent in establishing a business. The Group expects that its existing cash and cash equivalents, at the issuance date of these unaudited interim condensed consolidated financial statements will be sufficient to fund its operations and meet all of its obligations as they fall due, through mid-June 2026. These factors individually and collectively indicate that a material uncertainty exists that raises substantial doubt about the Group's ability to continue as a going concern for one year from the date of issuance of these unaudited interim condensed consolidated financial statements. The future viability of the Group is dependent on its ability to raise additional capital through public or private financings or collaboration agreements to finance its future operations, which may be delayed due to reasons outside of the Group's control including health pandemics and geopolitical risks. The sale of additional equity may dilute existing shareholders. The inability to obtain funding, as and when needed, would have a negative impact on the Group's financial condition and ability to pursue its business strategies. If the Group is unable to obtain the required funding to run its operations and to develop and commercialize its product candidates, the Group could be forced to delay, reduce or stop some or all of its research and development programs to ensure it remains solvent. Management continues to explore options to obtain additional funding, including through collaborations with third parties related to the future potential development and/or commercialization of its product candidates. However, there is no assurance that the Group will be successful in raising funds, closing collaboration agreements, obtaining sufficient funding on terms acceptable to the Group, or if at all, which could have a material adverse effect on the Group's business, results of operations and financial condition.

*The Business of the Group could be adversely affected by health pandemics and geopolitical risks*

The business of the Group could be adversely affected by health epidemics and geopolitical risks in regions where the Group or partners have concentrations of clinical trial sites or other business operations and could cause significant disruption in the operations of third-party manufacturers and CROs upon whom the Group or partners rely. Health pandemics may pose the risk that the Group, employees, contractors, collaborators, and partners may be prevented from conducting certain pre-clinical tests, clinical trials or other business activities for an indefinite period of time, including due to travel restrictions, quarantines, "stay-at-home" and "shelter-in-place" orders or shutdowns that have been or may in the future be requested or mandated by governmental authorities. For example, the COVID-19 pandemic has impacted the business of the Group and clinical trials led by the Group or partners, including as a result of delays or difficulties in clinical site initiation, difficulties in recruiting and retaining clinical site investigators and clinical site staff and interruption of the clinical supply chain or key clinical trial activities, such as clinical trial site monitoring, and supply chain interruptions caused by restrictions for the supply of materials for drug candidates or other materials necessary to manufacture product to conduct clinical and preclinical tests. Geopolitical risks such as Russia-Ukraine war or Middle East conflict may create global security concerns including the possibility of an expanded regional or global conflict and potential ramifications such as disruption of the supply chain including research and development activities being conducted by the Group and its strategic partners. Delays in research and development activities of the Group and its partners could increase associated costs and, depending upon the duration of any delays, require the Group and its partners to find alternative suppliers at additional expense. In addition, Russia-Ukraine war has had significant ramifications on global financial markets, which may adversely impact the ability of the Group to raise capital on favorable terms or at all.

*Discontinued operations, assets and liabilities held for sale related to the Neurosterix Transaction*

During the first quarter of 2024, it became highly probable that the Group would sell a part of its business constituted by its allosteric modulator drug discovery technology platform and a portfolio of preclinical programs (see note 21). As a consequence, the group recorded assets held for sale, liabilities held for sale as of March 31, 2024 and recognized discontinued operations in the financial line of the statements of comprehensive loss called "net loss from discontinued operations" in accordance with IFRS 5. The Group identified cash flows used in discontinued operations for the three month-period ended March 31, 2024 (see note 21). The identification of assets held for sale, liabilities held for sale and discontinued operations may require some degree of judgement.

*Investments accounted for using the equity method*

The Group received an equity interest of 20% in Neurosterix US Holdings LLC as part of the Neurosterix Transaction. The initial recognition of the investment has been accounted at a fair value based on a financial valuation of Neurosterix Group. This carrying amount is going to be increased or decreased to recognize the share of profit or loss of Neurosterix Group and tested for impairment whenever events or changes in circumstances indicate that it may not be recoverable.

**Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes** 

*Revenue recognition*

Revenue is primarily from fees related to licenses, milestones and research services. Given the complexity of the relevant agreements, judgements are required to identify distinct performance obligations, allocate the transaction price to these performance obligations and determine when the performance obligations are met. In particular, the Group's judgement over the estimated stand-alone selling price which is used to allocate the transaction price to the performance obligations is disclosed in note 16.

*Grants*

Grants are recorded at their fair value when there is reasonable assurance that they will be received and recognized as income when the Group has satisfied the underlying grant conditions. In certain circumstances, grant income may be recognized before explicit grantor acknowledgement that the conditions have been met.

*Accrued research and development costs*

The Group records accrued expenses for estimated costs of research and development activities conducted by third party service providers. The Group records accrued expenses for estimated costs of research and development activities based upon the estimated amount of services provided, but not yet invoiced, and these costs are included in accrued expenses on the balance sheets and within research and development expenses in the statements of comprehensive loss. These costs are a significant component of research and development expenses. Accrued expenses for these costs are recorded based on the estimated amount of work completed in accordance with agreements established with these third parties. Due to the nature of estimates, the Group may be required to make changes to the estimates after a reporting period as it becomes aware of additional information about the status or conduct of its research activities.

*Share-based compensation*

The Group recognizes an expense for share-based compensation based on the valuation of equity incentive units using the Black-Scholes valuation model. A number of assumptions related to the volatility of the underlying shares and to the risk-free rate are made in this model. Should the assumptions and estimates underlying the fair value of these instruments vary significantly from management's estimates, then the share-based compensation expense would be materially different from the amounts recognized.

*Equity instruments*

The group records in equity the pre-funded warrants sold to investors and the warrants granted to investors at a fair value calculated using Black-Scholes model.

*Pension obligations*

The present value of the pension obligations is calculated by an independent actuary and depends on a number of assumptions that are determined on an actuarial basis such as discount rates, future salary and pension increases, and mortality rates. Any changes in these assumptions will impact the carrying amount of pension obligations. The Group determines the appropriate discount rate at the end of each period. This is the interest rate that should be used to determine the present value of estimated future cash outflows expected to be required to settle the pension obligations. In determining the appropriate discount rate, the Group considers the interest rates of high-quality corporate bonds that are denominated in the currency in which the benefits will be paid, and that have terms to maturity approximating the terms of the related pension liability. Other key assumptions for pension obligations are based in part on current market conditions. Additional information is disclosed in note 15.

**4** **. Interim measurement note**

*Seasonality of the business:* The business is not subject to any seasonality, but expenses and corresponding revenue are largely determined by the phase of the respective projects, particularly with regard to external research and development expenditures.

*Costs:* Costs that incur unevenly during the financial year are anticipated or deferred in the interim report only if it would also be appropriate to anticipate or defer such costs at the end of the financial year.

**5. Segment reporting**

Management has identified one single operating segment, related to the discovery, development and commercialization of small-molecule pharmaceutical products.

*Information about products, services and major customers*

External income of the Group is derived from the business of discovery, development and commercialization of pharmaceutical products. Income primarily relates to research services provided to a pharmaceutical company and the fair value of services received from Neurosterix Group at zero cost (notes 10 and 21).

**Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes** 

*Information about geographical areas*

External income is exclusively recorded in the Swiss operating company.

Analysis of revenue from contract with customer and other income by nature is detailed as follows:

---

| | | |
|:---|:---|:---|
|  | **For the three months<br> Ended March 31,** | **For the three months<br> Ended March 31,** |
|  | **2025** | **2024** |
| Collaborative research funding |  | 233480 |
| Fair value of services received at zero cost from Neurosterix Group | 71055 |  |
| Other service income | - | 1430 |
| **Total** | **71055** | **234910** |

---

Analysis of revenue from contract with customer and other income by major counterparties is detailed as follows:

---

| | | |
|:---|:---|:---|
|  | **For the three months<br> Ended March 31,** | **For the three months<br> Ended March 31,** |
|  | **2025** | **2024** |
| Indivior PLC |  | 233480 |
| Neurosterix Group | 71055 |  |
| Other counterparties | - | 1430 |
| **Total** | **71055** | **234910** |

---

For more detail, refer to note 16 "Revenue from contract with customer" and note 17 "Other income".

The geographical allocation of long-lived assets is detailed as follows:

---

| | | |
|:---|:---|:---|
|  | **March 31, 2025** | **December 31, 2024** |
| Switzerland | 6287032 | 7136602 |
| France | 344 | 338 |
| **Total** | **6287376** | **7136940** |

---

The geographical analysis of operating costs is as follows:

---

| | | |
|:---|:---|:---|
|  | **For the three months<br> Ended March 31,** | **For the three months<br> Ended March 31,** |
|  | **2025** | **2024** |
| Switzerland | 673848 | 1021074 |
| United States of America | 2315 | 1646 |
| France | 1154 | 282 |
| **Total operating costs (note 18)** | **677317** | **1023002** |

---

The capital expenditure during the three-month period ended March 31, 2025 is nil (nil for the three-month period ended March 31, 2024).

**6** **. Cash and cash equivalents**

---

| | | |
|:---|:---|:---|
|  | **March 31, 2025** | **December 31, 2024** |
| Cash at bank and on hand | 2825484 | 3341738 |
| **Total cash and cash equivalents** | **2825484** | **3341738** |

---

Split by currency:

---

| | | |
|:---|:---|:---|
|  | **March 31, 2025** | **December 31, 2024** |
| CHF | 90.74% | 80.84% |
| USD | 5.76% | 14.90% |
| EUR | 2.77% | 2.42% |
| GBP | 0.73% | 1.84% |
| **Total** | **100.00%** | **100.00%** |

---

**Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes** 

The Group invests its cash balances into a variety of current accounts mainly with two Swiss banks whose external credit rating is P-1/A-1.

All cash and cash equivalents were held either at banks or on hand as of March 31, 2025 and December 31, 2024.

**7** **. Other current assets**

---

| | | |
|:---|:---|:---|
|  | **March 31, 2025** | **December 31, 2024** |
| Other financial assets | 6828 | 6496 |
| Trade and other receivables | 35361 | 15513 |
| Prepayments | 329605 | 169649 |
| Other short-term assets | - | 7967 |
| **Total other current assets** | **371794** | **199625** |

---

Prepayments increased by CHF 0.2 million as of March 31, 2025 compared to December 31, 2024 primarily due to the annual Directors and Officers (D&O) insurance premium and retirement benefits paid annually at the beginning of the year. The Group applies the IFRS 9 simplified approach to measuring expected credit losses ("ECL"), which uses a lifetime expected loss allowance for all trade receivables and other receivables. The Group has considered that the trade receivables and other receivables have a low risk of default based on historic loss rates and forward-looking information on macroeconomic factors affecting the ability of the third parties to settle invoices. As a result, expected loss allowance has been deemed as nil as of March 31, 2025 and December 31, 2024.

**8** **. Right-of-use assets**

---

| | | | |
|:---|:---|:---|:---|
| **Year ended December 31, 2024** | **Properties** | **Equipment** | **Total** |
| Opening net book amount | 328524 | 1808 | 330332 |
| Depreciation charge | (73337) | (677) | (74014) |
| Effect of lease modifications | 23940 |  | 23940 |
| Disposals | (7408) |  | (7408) |
| Assets transferred to Neurosterix Pharma Sàrl | (230141) | (1131) | (231272) |
| **Closing net book amount** | **41578** | **-** | **41578** |

---

---

| | | | |
|:---|:---|:---|:---|
| **As of December 31, 2024** | **Properties** | **Equipment** | **Total** |
| Cost | 111642 |  | 111642 |
| Accumulated depreciation | (70064) |  | (70064) |
| **Net book value** | **41578** |  | **41578** |

---

---

| | | |
|:---|:---|:---|
| **Period ended March 31, 2025** | **Properties** | **Total** |
| Opening net book amount | 41578 | 41578 |
| Depreciation charge | (2011) | (2011) |
| **Closing net book amount** | **39567** | **39567** |

---

---

| | | |
|:---|:---|:---|
| **As of March 31, 2025** | **Properties** | **Total** |
| Cost | 111642 | 111642 |
| Accumulated depreciation | (72075) | (72075) |
| **Net book value** | **39567** | **39567** |

---

**9** **. Equipment**

---

| | | |
|:---|:---|:---|
| **Year ended December 31, 2024** | **Equipment** | **Total** |
| Opening net book amount | 22604 | 22604 |
| Additions | 1273 | 1273 |
| Depreciation charge | (3759) | (3759) |
| Assets transferred to Neurosterix Pharma Sàrl | (18987) | (18987) |
| **Closing net book amount** | **1131** | **1131** |

---

**Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes** 

---

| | | |
|:---|:---|:---|
| **As of December 31, 2024** | **Equipment** | **Total** |
| Cost | 84775 | 84775 |
| Accumulated depreciation | (83644) | (83644) |
| **Net book value** | **1131** | **1131** |

---

---

| | | |
|:---|:---|:---|
| **Period ended March 31, 2025** | **Equipment** | **Total** |
| Opening net book amount | 1131 | 1131 |
| Depreciation charge | (107) | (107) |
| **Closing net book amount** | **1024** | **1024** |

---

---

| | | |
|:---|:---|:---|
| **As of March 31, 2025** | **Equipment** | **Total** |
| Cost | 84775 | 84775 |
| Accumulated depreciation | (83751) | (83751) |
| **Net book value** | **1024** | **1024** |

---

**10** **. Intangible assets**

---

| | | |
|:---|:---|:---|
| **Year ended December 31, 2024** | **Service<br> agreement** | **Total** |
| Opening net book amount |  |  |
| Additions | 182348 | 182348 |
| Depreciation charge | (182348) | (182348) |
| **Closing net book amount** | - | - |

---

---

| | | |
|:---|:---|:---|
| **As of December 31, 2024** | **Service<br> agreement** | **Total** |
| Cost | 182348 | 182348 |
| Accumulated depreciation | (182348) | (182348) |
| **Net book value** | - | - |

---

The service agreement relates to staff and infrastructure provided by Neurosterix Pharma Sàrl at zero cost in accordance with the Neurosterix Transaction (note 21). The depreciation charge was recognized at the rate at which these services were provided. During the first quarter of 2025, this agreement was not formally renewed, but Neurosterix agreed to allow the Group to have access to some employees and infrastructure at zero cost. The fair value of the services received at zero cost has been recognized as other income and other operating expenses for a total amount of CHF 71,055 for the three-month period ended March 31, 2025.

**11** **. Non-current financial assets**

---

| | | |
|:---|:---|:---|
|  | **March 31, 2025** | **December 31, 2024** |
| Security rental deposits | 7094 | 7089 |
| **Total non-current financial assets** | **7094** | **7089** |

---

Security rental deposits relate to office space. The applicable interest rate to such deposits is immaterial, and therefore, the value approximates amortized cost.

**12. Payables, accruals and other current liabilities**

---

| | | |
|:---|:---|:---|
|  | **March 31, 2025** | **December 31, 2024** |
| Trade payables | 286135 | 253290 |
| Social security and other taxes | 13254 | 22649 |
| Accrued expenses | 648782 | 518848 |
| Other current liabilities | 101243 | - |
| **Total** | **1049414** | **794787** |

---

**Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes** 

All payables mature within 3 months. Accrued expenses and trade payables primarily relate to R&D services from contract research organizations, consultants and professional fees. The total amount of payables and accruals increased by CHF 0.2 million as of March 31, 2025 compared to December 31, 2024 primarily due to increased G&A accrued expenses. The other current liabilities amount to CHF 0.1 million and primarily relate to funds received in advance for the future sales of treasury shares. The carrying amounts of payables do not materially differ from their fair values, due to their short-term nature.

**13** **. Share capital**

---

| | | | |
|:---|:---|:---|:---|
|  | **Number of shares** | **Number of shares** | **Number of shares** |
|  | **Common shares** | **Treasury shares** | **Total** |
| **Balance as of January 1, 2024** | **184354496** | **(59159103)** | **125195393** |
| Sale of shares under sale agency agreement |  | 3050665 | 3050665 |
| Net sale of shares under liquidity agreement | - | 19999 | 19999 |
| **Balance as of March 31, 2024** | **184354496** | **(56088439)** | **128266057** |
| Shares reclassed as treasury shares under IFRS 2 | - | (29958807) | (29958807) |
| **Balance as of March 31, 2024 IFRS 2** | **184354496** | **(86047246)** | **98307250** |

---

---

| | | | |
|:---|:---|:---|:---|
|  | **Number of shares** | **Number of shares** | **Number of shares** |
|  | **Common shares** | **Treasury shares** | **Total** |
| **Balance as of January 1, 2025** | **184354496** | **(56061527)** | **128292969** |
| Net sale of shares under liquidity agreement | - | 4001 | 4001 |
| **Balance as of March 31, 2025** | **184354496** | **(56057526)** | **128296970** |
| Shares reclassed as treasury shares under IFRS 2 | - | (29950268) | (29950268) |
| **Balance as of March 31, 2025 IFRS 2** | **184354496** | **(86007794)** | **98346702** |

---

As of March 31, 2025, 128,296,970 shares were outstanding excluding 56,057,526 treasury shares directly held by Addex Pharma SA and including 29,950,268 outstanding shares benefiting from our DSPPP, considered as treasury shares under IFRS 2 (note 14).

As of March 31, 2024, 128,266,057 shares were outstanding excluding 56,088,439 treasury shares directly held by Addex Pharma SA and including 29,958,807 outstanding shares benefiting from our DSPPP, considered as treasury shares under IFRS 2 (note 14).

The Group maintains a liquidity agreement with Kepler Cheuvreux ("Kepler"). Under the agreement, the Group has provided Kepler with cash and shares to enable them to buy and sell the Company's shares. As of March 31, 2025, 112,621 (December 31, 2024: 116,622) treasury shares are recorded under this agreement in the treasury share reserve and CHF 6,828 (December 31, 2024: CHF 6,496) is recorded in other financial assets.

During the three-month period ended March 31, 2025, the Group did not sell any treasury shares under the sale agency agreement with Kepler Cheuvreux (during the three-month period ended March 31, 2024, the Group sold 3,050,665 treasury shares at an average price of CHF 0.077 per share for gross proceeds of CHF 235,257).

On February 20, 2024, in accordance with Swiss law, the Company registered in the commercial register 6,120,000 new shares issued out of conditional capital from December 12, 2023 to December 31, 2023 following the exercise of pre-funded warrants granted to one institutional investor on April 3, 2023.

**14** **. Share-based compensation**

The total share-based compensation expense for equity incentive units recognized as continuing operating costs in the statement of comprehensive loss for the three-month period ended March 31, 2025 amounted to CHF 24,917 compared to CHF 58,347 for the three-month period ended March 31, 2024.

The total share-based compensation expense for equity incentive units recognized as discontinued operating costs in the statement of comprehensive loss under "net loss from discontinued operations" for the three-month periods ended March 31, 2025 is nil and amounted to CHF 327,682 for the three-month period ended March 31, 2024 (note 21).

As of March 31, 2025 and December 31, 2024 , 8,006,791 options were outstanding. During the same periods, 29,950,268 shares benefiting from our Deferred Strike Price Payment Plan (DSPPP) were outstanding. All the shares benefiting from our DSPPP have been recorded as treasury shares in accordance with IFRS 2 (see note 13).

**Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes** 

**15** **. Retirement benefits obligations**

The amounts recognized in the statement of comprehensive loss are as follows:

---

| | | |
|:---|:---|:---|
|  | **For the three months<br> ended March 31,** | **For the three months<br> ended March 31,** |
|  | **2025** | **2024** |
| Current service cost | (7522) | (3150) |
| Past service cost |  | 1070 |
| Interest cost | (5400) | (1795) |
| Interest income | 4860 | 1633 |
| **Company pension cost (note 19)** | **(8062)** | **(2242)** |

---

The Group's pension costs recognized as continuing operating costs in the statement comprehensive loss for the three-month ended March 31, 2025, amounted to CHF 8,062 (CHF 2,242 for the three-month periods ended March 31, 2024).

The Group's pension costs recognized as discontinued operations in the statement of loss under "net loss from discontinued operations" for the three-month ended March 31, 2025, is nil (CHF 42,493 for the three-month periods ended March 31, 2024).

The amounts recognized in the balance sheet are determined as follows:

---

| | | |
|:---|:---|:---|
|  | **March 31, 2025** | **December 31, 2024** |
| Defined benefit obligation | (2059558) | (2108384) |
| Fair value of plan assets | 1960198 | 1944133 |
| **Retirement benefit obligation** | **(99360)** | **(164251)** |

---

Retirement benefit obligation decreased by CHF 0.1 million as of March 31, 2025 compared to December 31, 2024 primarily due to changes in financial assumptions.

**16. Revenue from contract with customer**

*License & research agreement with Indivior PLC*

On January 2, 2018, the Group entered into an agreement with Indivior for the discovery, development and commercialization of novel GABAB PAM compounds for the treatment of addiction and other CNS diseases. This agreement included the selected clinical candidate, ADX71441. In addition, Indivior agreed to fund a research program at the Group to discover novel GABAB PAM compounds.

The contract contains two distinct material promises and performance obligations: (1) the selected compound ADX71441 which falls within the definition of a licensed compound, whose rights of use and benefits thereon was transferred in January 2018 and, (2) the research services to be conducted by the Group and funded by Indivior to discover novel GABAB PAM compounds for clinical development that may be discovered over the research term of the agreement and selected by Indivior.

Indivior has sole responsibility, including funding liability, for development of selected compounds under the agreement through preclinical and clinical trials, as well as registration procedures and commercialization, if any, worldwide. Indivior has the right to design development programs for selected compounds under the agreement. Through the Group's participation in a joint development committee, the Group reviews, in an advisory capacity, any development programs designed by Indivior. However, Indivior has authority over all aspects of the development of such selected compounds.

Under terms of the agreement, the Group granted Indivior an exclusive license to use relevant patents and know-how in relation to the development and commercialization of product candidates selected by Indivior. Subject to agreed conditions, the Group and Indivior jointly own all intellectual property rights that are jointly developed and the Group or Indivior individually own all intellectual property rights that the Group or Indivior develop individually. The Group has retained the right to select compounds from the research program for further development in areas outside the interest of Indivior including chronic cough. Under certain conditions, but subject to certain consequences, Indivior may terminate the agreement.

In January 2018, the Group received, under the terms of the agreement, a non-refundable upfront fee of USD 5.0 million for the right to use the clinical candidate, ADX71441, including all materials and know-how related to this clinical candidate. In addition, the Group is eligible for payments on successful achievement of pre-specified clinical, regulatory and commercial milestones totaling USD 330 million and royalties on net sales of mid-single digits to low double-digits.

**Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes** 

On February 14, 2019, Indivior terminated the development of their selected compound, ADX71441. Separately, Indivior funds research at the Group, based on a research plan to be mutually agreed between the parties, to discover novel GABAB PAM compounds. These future novel GABAB PAM compounds, if selected by Indivior, become licensed compounds. The Group agreed with Indivior to an initial research term and duration of two years with a funding of USD 4 million over the period for the Group's R&D costs incurred, that can be extended by twelve-month increments. R&D costs are calculated based on the costs incurred in accordance with the contract. Following Indivior's selection of one newly identified compound, the Group has the right to also select one additional newly identified compound. The Group is responsible for the funding of all development and commercialization costs of its selected compounds and Indivior has no rights to the Group's selected compounds. The initial two-year research term was expected to run from May 2018 to April 2020. In 2019, Indivior agreed to an additional research funding of USD 1.6 million, for the research period. On October 30, 2020, the research term was extended until June 30, 2021 and Indivior agreed to additional research funding of USD 2.8 million. Effective May 1, 2021, the research term was extended until July 31, 2022 and Indivior agreed additional research funding of CHF 3.7 million, of which CHF 2.7 million was paid to the Group and CHF 1.0 million paid directly by Indivior to third party suppliers that are supporting the funded research program. In August 2022, the research agreement was extended until March 31, 2023 and Indivior agreed to additional research funding of CHF 0.85 million. The reserved indications, where Addex retains exclusive rights to develop its own independent GABAB PAM program, have also been expanded to include chronic cough. Effective November 1, 2022, the research term was extended until June 30, 2023 and Indivior agreed to additional research funding of CHF 0.95 million. Effective July 1, 2023, the research agreement with Indivior has been extended until June 30, 2024 and Indivior committed additional research funding of CHF 2.7 million including CHF 1.1 million paid to the Group and CHF 1.6 million paid directly by Indivior to third party suppliers that are supporting the funded research program. On August 27, 2024, Indivior selected a compound for future development in substance use disorder and undertakes all future development of their selected compound. Under the terms of the agreement, the Group has also exercised its right to select a compound to advance its own independent GABAB PAM program for the treatment of chronic cough.

No amount has been recognized by the Group under this agreement for the three-month period ended March 31, 2025. For the same period ended March 31, 2024, the Group recognized CHF 0.2 million as revenue related to the research agreement that has been completed during the second half of 2024.

*Janssen Pharmaceuticals Inc. (formerly Ortho-McNeil-Janssen Pharmaceuticals Inc)*

On December 31, 2004, the Group entered into a research collaboration and license agreement with Janssen Pharmaceuticals Inc. (JPI). In accordance with this agreement, JPI has acquired an exclusive worldwide license to develop mGlu2 PAM compounds for the treatment of human health. The Group is eligible to receive up to EUR 109 million in success-based development and regulatory milestone, and low double-digit royalties on net sales. The Group considers these various milestones to be variable considerations as they are contingent upon achieving uncertain, future development stages and net sales. For this reason, the Group considers the achievement of the various milestones as binary events that will be recognized as revenue occurs.

In 2024, Janssen completed a Phase 2a proof of concept clinical trial of ADX71149 in epilepsy patients that did not achieve statistical significance for the primary endpoint of time for patients to reach baseline seizure count when ADX71149 was added to standard of care and decided to terminate the development of ADX71149. On April 17, 2025, the Group announced that the license agreement had been terminated and the program and all related intellectual property has been returned to the Group.

No amounts have been recognized under this agreement for the three-month period ended March 31, 2025 and 2024.

**17. Other income**

During the three-month period ended March 31, 2025, the Group recognized CHF 0.1 million related to the fair value of services received from Neurosterix Group at zero cost (note 10). The Group additionally recognized other income from IT consultancy agreements.

In September 2023, the Group was awarded a grant of CHF 0.5 million by Eurostars/Innosuisse to support the mGlu2 NAM program of which CHF 0.3 million were received in December 2023. The Group recognized CHF 38,401 from January 1, 2024 to April 2, 2024, the date when the program was transferred to Neurosterix Pharma Sàrl and recorded as discontinued operations (note 21). The remaining funds and deferred income of CHF 0.3 million recorded as assets and liabilities held for sale as of April 2, 2024, has been transferred to Neurosterix Pharma Sàrl.

**Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes** 

**18** **. Operating costs**

---

| | | |
|:---|:---|:---|
|  | **For the three months<br> Ended March 31,** | **For the three months<br> Ended March 31,** |
|  | **2025** | **2024** |
| Staff costs (note 19) | 101042 | 68682 |
| Depreciation (notes 8/9) | 2118 | 2938 |
| External research and development cost | 32583 | 179110 |
| Patent maintenance and registration cost | 43254 | 55539 |
| Professional fees | 302382 | 452010 |
| D&O insurance | 44650 | 51049 |
| Other operating costs | 151288 | 213674 |
| **Total operating costs** | **677317** | **1023002** |

---

The evolution of the total operating costs of continuing operations is mainly driven by G&A staff costs and professional fees.

During the three-month period ended March 31, 2025, total operating costs recognized as continuing operating costs decreased by CHF 0.3 million compared to the same period ended March 31, 2024, primarily due to decreased external research and development costs of CHF 0.1 million and professional fees of CHF 0.1 million.

Total operating costs recognized as discontinued operations, primarily related to staff costs and external research and development, amounted to CHF 2.0 million for the three-month period ended March 31, 2024 and were nil for the same period ended March 31, 2025 (note 21).

**19** **. Staff costs**

---

| | | |
|:---|:---|:---|
|  | **For the three months <br> Ended March 31,** | **For the three months <br> Ended March 31,** |
|  | **2025** | **2024** |
| Wages and salaries | 84769 | 54284 |
| Social charges and insurances | 5775 | 6210 |
| Value of share-based services | 2436 | 5946 |
| Retirement benefit (note 15) | 8062 | 2242 |
| **Total staff costs** | **101042** | **68682** |

---

During the three-month period ended March 31, 2025, total staff costs recognized as continuing operating costs remained stable at CHF 0.1 million compared to the same period ended March 31, 2024.

Staff costs recognized as discontinued operations amounted to CHF 1.4 million for the three-month period ended March 31, 2024 and were nil for the same period ended March 31, 2025 (note 21).

**20** **. Finance result, net**

---

| | | |
|:---|:---|:---|
|  | **For the three months<br> Ended March 31,** | **For the three months<br> Ended March 31,** |
|  | **2025** | **2024** |
| Interest income |  | 7571 |
| Interest cost | (31) | (146) |
| Interest expense on leases | (517) | (465) |
| Foreign exchange (losses)/gains, net | (18602) | 45954 |
| **Finance result, net** | **(19150)** | **52914** |

---

**Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes** 

**21. Discontinued operations**

On February 8, 2024, the Group signed a non-binding term sheet with Perceptive Advisors related to the divestment of part of its business. On April 2, 2024, the sale became effective. The allosteric modulator drug discovery technology platform and a portfolio of preclinical programs have been divested to a new Swiss company, Neurosterix Pharma Sàrl that has received committed funding of USD 65 million from a syndicate of investors led by Perceptive Advisors (Perceptive Xontogeny Venture Fund II L.P, Perceptive Life Sciences Master Fund Ltd and Acorn Bioventures 2, L.P) (the "Neurosterix Transaction" or "Transaction") from April 2, 2024 to the issuance date of these unaudited condensed consolidated financial statements. As part of the Transaction, the Group received gross proceeds of CHF 5.0 million in cash and an equity interest representing 20% of Neurosterix US Holdings LLC (note 1). The Group retained its partnerships with Janssen Pharmaceuticals, Inc. and Indivior PLC, as well as unpartnered clinical stage assets including dipraglurant for Parkinson's disease and post-stroke/TBI recovery and its preclinical GABAB PAM program for chronic cough. The Transaction includes the transfer of the associated R&D staff and infrastructure. As part of the Transaction, the Group and Neurosterix Pharma Sàrl entered into a service agreement which provides the Group with access to certain staff and infrastructure at zero cost to ensure the operation of the Group retained business until December 31, 2024. During the first quarter of 2025, this agreement was not formally renewed, but Neurosterix agreed to allow the Group to have access to some employees and infrastructure at zero cost (note 10).

As the allosteric modulator drug discovery technology platform and a portfolio of preclinical programs have been sold on April 2, 2024, such activities have been identified as discontinued operations for the period beginning on January 1, 2024 and terminating on April 1, 2024.

**Financial performance of discontinued operations:**

---

| | | |
|:---|:---|:---|
|  | **For the three months <br> Ended March 31,** | **For the three months <br> Ended March 31,** |
|  | **2025** | **2024** |
| **Other income** |  | **38401** |
| Research and development |  | (1320098) |
| General and administration |  | (636281) |
| **Total operating costs** |  | **(1956379)** |
| **Operating loss** |  | **(1917978)** |
| Finance expense |  | (5672) |
| **Net loss before tax** |  | **(1923650)** |
| Income tax expense |  | - |
| **Net loss from discontinued operations** |  | **(1923650)** |
| Legal fees expenses related to the sale of discontinued operations |  | (428311) |
| **Total net loss from discontinued operations** |  | **(2351961)** |

---

**Operating costs of discontinued operations:**

---

| | | |
|:---|:---|:---|
|  | **For the three months <br> Ended March 31,** | **For the three months <br> Ended March 31,** |
|  | **2025** | **2024** |
| Staff costs |  | 1368966 |
| Depreciation |  | 67422 |
| External research and development costs |  | 331678 |
| Laboratory consumables |  | 17735 |
| Patent maintenance and registration costs |  | 62563 |
| Professional fees |  | 38271 |
| Short-term leases |  | 8329 |
| Other operating costs |  | 61415 |
| **Total discontinued operating costs** |  | **1956379** |

---

**Assets classified as held for sale as of March 31, 2024 :**

---

| | |
|:---|:---|
|  | **March 31, 2024** |
| Cash and cash equivalents | 305809 |
| Prepayments and other receivables | 186522 |
| Security rental deposits | 47290 |
| Property, plant and equipment | 18987 |
| Right of use assets | 231272 |
| **Total Assets held for sale** | **789880** |

---

**Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes** 

**Liabilities directly associated with assets classified as held for sale as of March 31, 2024:**

---

| | |
|:---|:---|
|  | **March 31, 2024** |
| Current lease liabilities | 242416 |
| Payables and accruals | 366485 |
| Deferred income | 285809 |
| Retirement benefits obligations | 433508 |
| **Total Liabilities held for sale** | **1328218** |

---

**Cash flows of discontinued operations:**

---

| | | |
|:---|:---|:---|
|  | **For the three months<br> Ended March 31,** | **For the three months<br> Ended March 31,** |
|  | **2025** | **2024** |
| **Net loss from discontinued operations** |  | **(1923650)** |
| Adjustments for: |  |  |
| &nbsp;&nbsp;&nbsp;Depreciation |  | 67422 |
| &nbsp;&nbsp;&nbsp;Value of share-based services |  | 327682 |
| &nbsp;&nbsp;&nbsp;Post-employment benefits |  | (27338) |
| &nbsp;&nbsp;&nbsp;Finance cost net |  | 5672 |
| Decrease in other receivables |  | 2622 |
| Increase in prepayments |  | (593142) |
| Increase in payables and accruals |  | 496472 |
| Decrease in deferred income |  | (38401) |
| **Net cash flow used in operating activities** |  | **(1682661)** |
| **Cash flows used in financing activities** |  |  |
| Principal element of lease payment |  | (63770) |
| Interest paid |  | (5672) |
| **Net cash used in financing activities** |  | **(69442)** |
| **Net cash used in discontinued activities** |  | **(1752103)** |

---

**22. Interests in associates**

On April 2, 2024, the Group received an equity interest of 20% in Neurosterix US Holdings LLC domiciliated in the US and parent company of Neurosterix Pharma Sàrl as part of Neurosterix transaction (note 21). Neurosterix Group primarily operates in Switzerland and uses Swiss franc as functional currency and US Dollars as presentation currency.

The carrying amount of the equity-accounted investment in Neurosterix Group has changed as follows during the three-month period ended March 31, 2025:

---

| | |
|:---|:---|
|  | **For the three<br> months ended<br> March 31, 2025** |
| **Beginning of the period** | **7087142** |
| Share of net loss of Neurosterix Group | (847451) |
| **End of the period** | **6239691** |

---

The 20% equity interest in Neurosterix US Holdings LLC received by the Group on April 2, 2024 was initially valued at CHF 9.43 million using a financial valuation of the Neurosterix Group. From April 2, 2024 to March 31, 2025, the share of net loss of Neurosterix Group amounted to CHF 3.2 million in accordance with IAS 28. The loss recognized for the period primarily reflects expenditures related to research and development and general and administrative activities, which are incurred in the ordinary course of Neurosterix operations. As of March 31, 2025, the equity-accounted investment is not impaired.

**23** **. Loss per share**

Basic and diluted loss per share is calculated by dividing the loss attributable to equity holders of the Company by the weighted average number of shares in issue during the period excluding treasury shares.

**Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes** 

---

| | | |
|:---|:---|:---|
|  | **For the three months<br> Ended March 31,** | **For the three months<br> Ended March 31,** |
|  | **2025** | **2024** |
| Net loss from continuing operations | (1472863) | (735178) |
| Net loss from discontinued operations | - | (2351961) |
| **Net loss attributable to equity holders of the company** | **(1472863)** | **(3087139)** |
| Weighted average number of shares in issue | 98345268 | 97534676 |
| **Basic and diluted loss per share** | **(0.01)** | **(0.03)** |
| From continuing operations | (0.01) | (0.01) |
| From discontinued operations |  | (0.02) |

---

The Company has three categories of dilutive potential shares: treasury shares, share options and warrants which have been ignored in the calculation of the loss per share for the three-month periods ended March 31, 2025 and 2024, as they would be antidilutive.

**24** **. Related party transactions**

Related parties include members of the Board of Directors and the Executive Management of the Group. The following transactions were carried out with related parties:

***Key management compensation***

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **For the three months<br> Ended March 31,** | **For the three months<br> Ended March 31,** | **For the three months<br> Ended March 31,** | **For the three months<br> Ended March 31,** |
|  | **2025** | **2024** | **2025** | **2024** |
|  | **Continuing operations** | **Continuing operations** | **Discontinued operations** | **Discontinued operations** |
| Salaries, other short-term employee benefits and post-employment benefits | 97293 | 59828 |  | 319348 |
| Share-based compensation | 24518 | 52398 |  | 260887 |
| **Total** | **121811** | **112226** |  | **580235** |

---

The compensation costs to key management related to continuing operations remained stable at CHF 0.1 million during the three-month period ended March 31, 2025 and 2024. During the three-month period ended March 31, 2025, the compensation costs to key management related to discontinued operations was nil and amounted to CHF 0.6 million for the three-month period ended March 31, 2024.

The Group has a net payable to the Board of Directors and Executive Management of CHF 0.1 million as of March 31, 2025 and December 31, 2024. Share-based compensation relates to the fair value of equity incentive units recognized through profit and loss following their vesting plan.

***Transactions with Neurosterix Group***

On April 2, 2024, as part of the Neurosterix transaction, a service agreement was concluded in order to provide to the Group with access to certain staff and infrastructure at zero cost to ensure the operation of the Group retained business until December 31, 2024. During the second quarter of 2025, this agreement was not formally renewed, but Neurosterix agreed to allow the Group to have access to some employees and infrastructure at zero cost. The fair value of the services received at zero cost has been recognized as other income and other operating expenses for a total amount of CHF 71,055 for the three-month period ended March 31, 2025.

**25** **. Events after the balance sheet date**

From April 1, 2025, to the issuance date of these condensed interim consolidated financial statements, the Group sold 11,094,913 treasury shares at an average price of CHF 0.06 for total gross proceeds of CHF 669,102.

On April 17, 2025, the Group announced that Janssen terminated the license agreement for the development of ADX71149 and returned the program including all related intellectual property to the Group.

## Exhibit 99.2

**Exhibit 99.2**

**MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION**

**AND RESULTS OF OPERATIONS**

**Overview**

We are a clinical-stage pharmaceutical company focused on the development of a portfolio of novel orally available small molecule drug candidates. Our business comprises of a pipeline of proprietary clinical and preclinical stage drug candidates that are being developed by our partners and internally. We or our partners are developing these clinical and preclinical stage proprietary drug candidates for diseases for which there are no approved therapies or where improved therapies are needed including post-stroke sensorimotor recovery, traumatic brain injury, or TBI, recovery, substance use disorder, or, SUD, and chronic cough. We also hold a 20% equity interest in a spin out company, Neurosterix US Holdings LLC, a private company developing a portfolio of preclinical stage proprietary drug candidates for schizophrenia, mood disorders and cognition.

Our lead development compound is dipraglurant, a metabotropic glutamate receptor subtype 5 negative allosteric modulator, or mGlu5 NAM, currently under evaluation for future development in post-stroke/TBI recovery. On April 30, 2025, we announced entering into an option and collaboration agreement with Sinntaxis AB for an exclusive license to intellectual property covering the use of mGlu5 inhibitors for the treatment of brain injury recovery. The agreement also includes a research collaboration under which the Sinntaxis team will complete evaluation of dipraglurant for the treatment of brain injury recovery.

Our second development compound, ADX71149 is a novel orally active metabotropic glutamate receptor subtype 2 positive allosteric modulator, or mGlu2 PAM. On July 22, 2024, we announced that our Partner Janssen terminated the development of drug candidate ADX71149, because the Phase 2 study did not achieve statistical significance for the primary endpoint. On April 17, 2025, we announced that our partner Janssen terminated our partnership agreement and returned to us the program including all related intellectual property to the Group. We are currently evaluating the future development of ADX71149.

Our third development program is GABAB PAM for substance use disorders. In 2024, we completed a funded research program to discover novel gamma-aminobutyric acid subtype-b positive allosteric modulators, or GABAB PAMs, for Indivior PLC, or Indivior. On August 27, 2024, Indivior selected a compound for future development in substance use disorder and undertakes all future development of their selected compound. On May 12, 2025, we announced that our partner, Indivior, had successfully completed IND enabling studies with their selected compound.

Our fourth development program is GABAB PAM for chronic cough. Under the terms of the agreement with Indivior, we have exercised our right to select a compound to advance our own independent GABAB PAM program for the treatment of chronic cough. On June 6, 2025, we announced robust anti-tussive activity of our selected compound in multiple preclinical models of chronic cough compared to reference drugs and are currently completing preclinical evaluation.

We cannot forecast with any degree of certainty which proprietary products or indications, if any, will be subject to future collaborative arrangements, in whole or in part, and how such arrangements would affect our development plan or capital requirements. To date, we have secured grants and other funding from government and non-governmental organizations. As we advance our clinical and preclinical programs, we will continue to apply for subsidies, grants and government or agency sponsored studies that could offset or reduce our development costs.

The development and commercialization of drugs is highly competitive. We compete with a variety of multinational pharmaceutical companies and specialized pharmaceutical companies, including products approved for marketing and/or drug candidates under development, for each of the drug candidates and each of the indications for which we are developing. Furthermore, government authorities in the United States, at the federal, state and local levels, and in other countries, extensively regulate, among other things, the research, development, testing, manufacture, packaging, storage, recordkeeping, labeling, advertising, promotion, distribution, marketing, import and export of pharmaceutical products, such as those we are developing. The processes for obtaining regulatory approvals in the United States and in foreign countries, along with subsequent compliance with applicable statutes and regulations, require the expenditure of substantial time and financial resources.

We were founded in May 2002 and completed our initial public offering of shares on the SIX Swiss Exchange in May 2007. On January 29, 2020, we listed American Depositary Shares (ADSs) representing our shares on the Nasdaq Stock Market following the United States Securities and Exchange Commission (SEC) having declared our registration statements on Forms F-1 and F-6 effective. On October 6, 2023, we filed a post-effective amendment to the form F-6 in Addex Therapeutics in order to change our ADS ratio from one ADS to six shares to a new ratio of one ADS to one hundred and twenty shares. The ADS ratio change has been effective since October 23, 2023 and had the same effect as a one to twenty ADS reverse split. The ADS ratio change had no impact on the Company's underlying shares and was intended to enable the Company to regain compliance with the Nasdaq minimum bid price requirement of ADSs. On November 8, 2023, the company announced that it had received a written notification from Nasdaq confirming that the compliance had been regained.

**MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION**

**AND RESULTS OF OPERATIONS**

Our operations to date have included organizing and staffing our company, raising capital, out-licensing rights to our research stage programs including our mGlu2 PAM and GABAB PAM programs and conducting preclinical studies and clinical trials.

As of March 31, 2025, we have generated CHF 66.8 million of revenue from the sale of license rights and conducting funded research activities for certain of our research programs. We have historically financed our operations mainly through the sale of equity. Through March 31, 2025, we had raised an aggregate of CHF 355.4 million of gross proceeds from the sale of equity.

We have incurred losses for a total amount of CHF 354.8 million since our inception. Our net losses were CHF 1.5 million and CHF 3.1 million for the three-month periods ended March 31, 2025 and March 31, 2024, respectively. We expect to continue to incur significant expenses and operating losses in the medium to long term. We anticipate that our expenses will increase significantly in connection with our ongoing and future activities as we:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· continue
to invest in our portfolio of preclinical and clinical stage programs;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· hire additional research and development, and general and administrative
personnel;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· maintain, expand and protect our intellectual property portfolio;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· identify and in-license or acquire additional drug candidates; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· incur additional costs associated with operating as a public company in the
United States.

We will need substantial additional funding to support our operating activities as we advance our research and drug candidates through clinical development, seek regulatory approval and prepare for commercialization, if any, of our product candidates are approved. Adequate funding may not be available to us on acceptable terms, or at all.

We have no manufacturing facilities, and all of our manufacturing activities are contracted out to third parties. Additionally, we currently utilize third-party contractors to carry out a significant proportion of our research and development activities. Furthermore, we do not yet have a sales organization.

**The Neurosterix Transaction**

On April 2, 2024, we divested our allosteric modulator discovery platform and a portfolio of pre-clinical programs to a new Swiss company, Neurosterix Pharma Sàrl (equivalent to an LLC), focused on the discovery and development of novel orally available allosteric modulator drug candidates, including M4 PAM for schizophrenia, mGlu7NAM for stress related disorders and mGlu2NAM for mild neurocognitive disorders. In connection with the Transaction, we received gross proceeds of CHF 5.0 million and a 20% equity interest in Neurosterix US Holdings LLC, the parent company of Neurosterix Pharma Sàrl. Neurosterix US Holdings LLC received a total of USD 65.0 million in funding commitments from a syndicate of investors led by Perceptive Advisors from April 2, 2024 to the issuance date of these unaudited condensed consolidated financial statements.

The divestment of our discovery platform and early-stage programs includes the transfer of the associated research and development staff, with a service agreement to allow key members of staff to support us in achieving our business strategy at zero cost for us. During the first quarter of 2025, this agreement was not formally renewed, but Neurosterix agreed to allow the Group to have access to some employees and infrastructure at zero cost.

**License Agreement with Indivior**

In January 2018, we entered into an agreement with Indivior for the discovery, development and commercialization of novel GABAB PAM compounds for the treatment of addiction and other CNS diseases.

**MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION**

**AND RESULTS OF OPERATIONS**

This agreement included the selected clinical candidate, ADX71441. In addition, Indivior agreed to fund a research program at Addex to discover novel GABAB PAM compounds.

Indivior has sole responsibility, including funding liability, for development of selected compounds under the agreement through preclinical and clinical trials, as well as registration procedures and commercialization, if any, worldwide. Indivior has the right to design development programs for selected compounds under the agreement. Through our participation in a joint development committee, we review, in an advisory capacity, any development programs designed by Indivior. However, Indivior has authority over all aspects of the development of such selected compounds.

Under terms of the agreement, we have granted Indivior an exclusive license to use relevant patents and know-how in relation to the development and commercialization of drug candidates selected by Indivior. Subject to agreed conditions, Addex and Indivior jointly own all intellectual property rights that are jointly developed, and Addex or Indivior individually own all intellectual property rights that Addex or Indivior develop individually. Addex has retained the right to select compounds from the research program for further development in areas outside the interest of Indivior including chronic cough. Under certain conditions, but subject to certain consequences, Indivior may terminate the agreement.

In January 2018, under terms of the agreement, we received a non-refundable upfront fee of USD 5.0 million for the right to use the clinical candidate, ADX71441, including all materials and know-how related to this clinical candidate. On February 14, 2019, Indivior terminated the development of their selected compound, ADX71441.

Separately, Indivior funded research at Addex, based on a research plan to mutually agreed between the parties, to discover novel GABAB PAM compounds. These future novel GABAB PAM compounds, if selected by Indivior, become licensed compounds. We agreed with Indivior to an initial research term and duration of two years with a funding of USD 4.0 million over the period for our R&D costs incurred, that can be extended by twelve-month increments. Following Indivior's selection of one newly identified compound, Addex has the right to also select one additional newly identified compound. Addex was responsible for the funding of all development and commercialization costs of its selected compounds and Indivior has no rights to the Addex selected compounds. The initial two-year research term ran from May 2018 to April 2020. In 2019, Indivior agreed to additional research funding of USD 1.6 million and on October 30, 2020, the research term was extended until June 30, 2021 and Indivior agreed to further additional research funding of USD 2.8 million. Effective May 1, 2021, the research term was extended until July 31, 2022 and Indivior agreed additional research funding of CHF 3.7 million, of which CHF 2.7 million has been paid to us, and CHF 1.0 million paid directly by Indivior to third party suppliers that supported the funded research program. In August 2022, the research agreement was extended until March 31, 2023 with additional research funding of CHF 0.85 million. The reserved indications, where Addex retains exclusive rights to develop its own independent GABAB PAM program, were also expanded to include chronic cough. Effective November 1, 2022 the research term was extended until June 30, 2023 and Indivior agreed to additional research funding of CHF 0.95 million. Effective July 1, 2023, the research term was extended until June 30, 2024 and Indivior agreed to additional research funding of CHF 2.7 million including CHF 1.1 million received directly by us and CHF 1.6 million paid directly by Indivior to third party suppliers that are supporting the funded research program.

On August 27, 2024, Indivior selected a compound for future development in substance use disorders and now undertake all future development of their selected compound. Under the terms of the agreement, we have also exercised our right to select a compound to advance our own independent GABAB PAM program for the treatment of chronic cough. Under the license agreement, we are as well eligible for payments on successful achievement of pre-specified clinical, regulatory and commercial milestones totaling USD 330 million. In addition, we are eligible for tiered royalties from high single digits to low double digits on net sales of applicable products on a country-by country-basis. The term of the royalty for each licensed product in any particular country commences on such product's launch and ends on the latest of ten -year anniversary of launch, expiration of certain applicable patent rights, and expiration of certain applicable marketing or data exclusivity periods.

The contract contains two distinct material promises and performance obligations: (1) the selected compound ADX71441 which falls within the definition of a licensed compound, whose rights of use and benefits thereon was transferred in January 2018 and, (2) the research services to be conducted by Addex and funded by Indivior to discover novel GABAB PAM compounds for clinical development that may be discovered over the research term of the agreement and selected by Indivior.

**MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION**

**AND RESULTS OF OPERATIONS**

**Components of Results of Operations**

***Revenue***

From the beginning of January 2017 through March 31, 2025, we recognized CHF 18.8 million as revenue primarily under our license agreement with Indivior. We do not have approval to market or commercialize any of our drug candidates, we have never generated revenue from the sale of products and we do not expect to generate any revenue from product sales for the foreseeable future. Prior to approval of a drug candidate, we will seek to generate revenue from a combination of license fees, milestone payments in connection with collaborative or strategic relationships, royalties resulting from the licensing of our drug candidates and payments from sponsored research and development activities as well as grants from governmental and non-governmental organizations.

Revenue from collaborative arrangements comprises the fair value for the sale of products and services, net of value added tax, rebates and discounts. Revenue from the rendering of services is recognized in the accounting period in which the services are rendered, by reference to completion of the specific transaction assessed on the basis of the actual service provided as a proportion of the total service to be provided. Revenue from collaborative arrangements may include the receipt of non-refundable license fees, milestone payments, and research and development payments. When we have continuing performance obligations under the terms of the arrangements, non-refundable fees and payments are recognized as revenue by reference to the completion of the performance obligation and the economic substance of the agreement.

Our revenue has varied, and we expect revenue to continue to vary, substantially from year to year, depending on the structure and timing of milestone events, as well as our development and commercialization strategies and those of our collaboration partners for our drug candidates. We, therefore, believe that historical period to period comparisons are not meaningful and should not be relied upon as an indicator of our future revenue and performance potential.

***Other Income***

From the beginning of January 2017 through March 2025, we recognized CHF 1.8 million as other income including CHF 1.2 million relating to grants from The Michael J. Fox Foundation for Parkinson's Research, or MJFF, to finance certain clinical activities related to dipraglurant development in Parkinson's disease levodopa-induced dyskinesia, or PD-LID, and other discovery activities.

In July 2019, we received a grant from Eurostars/Innosuisse for CHF 0.5 million to support our mGlu7 NAM program totally recognized as income as of December 31, 2021. The mGlu7 NAM program has been transferred to Neurosterix Pharma Sàrl on April 2, 2024.

In September 2023, we received a grant from Eurostars/Innosuisse for CHF 0.5 million to support the mGlu2 NAM program of which CHF 0.3 million were received in December 2023. We recognized CHF 38,401 from January 1, 2024 to April 2, 2024, the date when the program was transferred to Neurosterix Pharma Sàrl and recorded as discontinued operations. The remaining funds and deferred income of CHF 0.3 million recorded as assets and liabilities held for sale as of April 2, 2024 have been transferred to Neurosterix Pharma Sàrl.

Grants are recognized at their fair value where there is reasonable assurance that the grant will be received and that we will comply with all associated conditions. Grants relating to costs are recognized as other income in the statement of comprehensive loss over the period necessary to match them with the costs that they are intended to compensate.

During the three-month period ended March 31, 2025, we recognized the fair value of services received from Neurosterix Group at zero cost for CHF 0.1 million as other income and other operating expenses.

***Operating Expenses***

***Research and Development Costs***

From the beginning of January 2017 through March 2025, we incurred CHF 67.2 million in research and development costs. They consist mainly of direct research costs, which include costs associated with the use of contract research organizations, or CROs, and consultants hired to assist on our research and development activities, personnel costs, share-based compensation for our employees and consultants, costs related to regulatory affairs and intellectual property, as well as depreciation for assets used in research and development activities. Following the Neurosterix Transaction executed on April 2, 2024, research and development costs no longer include personnel costs and share-based compensation for employees. The research and development costs related to divested activities have been recognized in the statements of comprehensive loss under "Net loss from discontinued operations" from January 1, 2024 to the sale of a part of our business on April 2, 2024. We currently use our consultants and CRO's across our research and development programs.

**MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION**

**AND RESULTS OF OPERATIONS**

The following table provides a breakdown of our outsourced research and development costs that are directly attributable to the specified programs for the three-month period ended March 31, 2025 and 2024:

---

| | | |
|:---|:---|:---|
|  | **For the three months<br> Ended March 31,** | **For the three months<br> Ended March 31,** |
|  | **2025** | **2024** |
| GABAB PAM | 30 | 127 |
| Dipraglurant | 2 | 52 |
| **Total outsourced research and development costs** | **32** | **179** |

---

Our research and development expenses are low due to the Neurosterix Transaction. We have no ongoing self-funded clinical studies and in the medium and long term, our expenses may increase, particularly as we continue to the development of a GABAB PAM drug candidate, initiate further clinical trials and seek marketing approval for our drug candidates.

At this time, we cannot reasonably estimate or know the nature, timing and estimated costs of the efforts that will be necessary to complete the development of our drug candidates. We are also unable to predict when, if ever, material net cash inflows will commence from sales of our drug candidates. This is due to the numerous risks and uncertainties associated with developing such drug candidates, including:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· uncertainty related to discovering clinical candidates;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· uncertainty related to efficiently manufacturing and distributing
drug products;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· competitor intellectual property restraining our freedom to
operate; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· timing of initiation, completion and outcome of further clinical
trials;

In addition, the probability of success for any of our drug candidates will depend on numerous factors, including competition, manufacturing capabilities and commercial viability. A change in the outcome of any of these variables with respect to the development of any of our drug candidates would significantly change the costs, timing and viability associated with the development of that drug candidate.

***General and Administrative Costs***

General and administrative costs consist primarily of personnel costs, including salaries, benefits and share-based compensation cost for our employees as well as corporate facility costs not otherwise included in research and development expenses, legal fees related to corporate matters and fees for accounting and financial or tax consulting services. Our general and administrative costs are lower due to the Neurosterix Transaction.

***Finance Result, Net***

Finance result net consists mainly of currency exchange differences, primarily related to U.S dollar currency exchange differences.

***Net loss from discontinued operations***

Net loss from discontinued operations has been recognized in the statement of comprehensive loss under "net loss from discontinued operations". It primarily relates to research and development costs, general and administrative costs and finance result incurred from January 1, 2024 to the sale of a part of our business executed on April 2, 2024.

**Share of net loss of investments accounted for using the equity method**

We received an equity interest of 20% in Neurosterix US Holdings LLC as part of the Neurosterix Transaction. The equity interest has been recognized as an investment at fair value based on a financial valuation of Neurosterix Group. The carrying amount of the investment is going to be increased or decreased to recognize the share of profit or loss of Neurosterix Group and tested for impairment whenever events or changes in circumstances indicate that it may not be recoverable.

**MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION**

**AND RESULTS OF OPERATIONS**

**Analysis of Results of Operations**

The following table presents our consolidated results of operations for the three-month periods ended March 31, 2025 and 2024:

---

| | | |
|:---|:---|:---|
|  | **For the three months<br> ended March 31,** | **For the three months<br> ended March 31,** |
|  | **2025** | **2024** |
| Revenue |  | 234 |
| Other income | 71 | 1 |
| Research and development costs | (156) | (245) |
| General and administrative costs | (521) | (778) |
| **Operating loss from continuing operations** | **(606)** | **(788)** |
| Finance income |  | 54 |
| Finance expense | (19) | (1) |
| **Finance result** | **(19)** | **53** |
| Share of net loss of investments accounted for using the equity method | (848) | - |
| **Net loss before tax from continuing operations** | (1473) | (735) |
| Income tax expense | - | - |
| **Net loss from continuing operations** | **(1473)** | **(735)** |
| Net loss from discontinued operations (attributable to equity holders of the Group) | - | (2352) |
| **Net loss for the period** | **(1473)** | **(3087)** |

---

***Three Months Ended March 31, 2025 Compared to Three Months Ended March 31, 2024***

***Revenue***

The following table sets forth our revenue in the three-month periods ended March 31, 2025 and 2024:

---

| | | |
|:---|:---|:---|
|  | **For the three months ended <br> March 31,** | **For the three months ended <br> March 31,** |
|  | **2025** | **2024** |
|  | **(CHF in thousands)** | **(CHF in thousands)** |
| Collaborative research funding |  | 234 |
| **Total** |  | **234** |

---

Revenue decreased by CHF 0.2 million in the three-month period ended March 31, 2025, compared to the three-month period ended March 31, 2024, primarily due to the completion of the research phase of our agreement with Indivior on June 30, 2024.

***Other Income***

The following table sets forth our other income in the three-month periods ended March 31, 2025 and 2024:

---

| | | |
|:---|:---|:---|
|  | **For the three months ended<br> March 31,** | **For the three months ended<br> March 31,** |
|  | **2025** | **2024** |
|  | **(CHF in thousands)** | **(CHF in thousands)** |
| Fair value of services received at zero cost from Neurosterix Group | 71 |  |
| Other service income | - | 1 |
| **Total** | **71** | **1** |

---

Other income increased by CHF 0.1 million in the three-month period ended March 31, 2025, compared to the three-month ended period March 31, 2024, primarily due to the fair value of the services received at zero cost from Neurosterix Group.

**MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION**

**AND RESULTS OF OPERATIONS**

***Research and Development Expenses***

The following table sets forth our research and development expenses in the three-month periods ended March 31, 2025 and 2024:

---

| | | |
|:---|:---|:---|
|  | **For the three months ended<br> March 31,** | **For the three months ended<br> March 31,** |
|  | **2025** | **2024** |
|  | **(CHF in thousands)** | **(CHF in thousands)** |
| GABAB PAM | 30 | 127 |
| Dipraglurant | 2 | 52 |
| &nbsp;&nbsp;&nbsp;**Subtotal outsourced R&D per program** | **32** | **179** |
| Patent maintenance and registration costs | 43 | 55 |
| Other operating costs | 81 | 11 |
| &nbsp;&nbsp;&nbsp;**Subtotal unallocated R&D expenses** | **124** | **66** |
| **Total** | **156** | **245** |

---

Research and development expenses decreased by CHF 0.1 million in the three-month period ended March 31, 2025, compared to the three-month ended period March 31, 2024, primarily due to lower GABAB PAM outsourced R&D expenses as we completed the research phase of our agreement with Indivior on June 30, 2024.

***General and Administrative Costs***

The following table sets forth our general and administrative costs in the three-month periods ended March 31, 2025 and 2024:

---

| | | |
|:---|:---|:---|
|  | **For the three months ended<br> March 31,** | **For the three months ended<br> March 31,** |
|  | **2025** | **2024** |
|  | **(CHF in thousands)** | **(CHF in thousands)** |
| Staff costs | 101 | 69 |
| Professional fees | 302 | 452 |
| D&O Insurance | 45 | 51 |
| Other operating costs | 73 | 206 |
| **Total** | **521** | **778** |

---

General and administrative costs decreased by CHF 0.3 million in the three-month period ended March 31, 2025, compared to the three-month period ended March 31, 2024, primarily due to decreased legal fees.

**Capital Resources**

Since our inception through March 31, 2025, we have generated CHF 66.8 million of revenue and have incurred net losses and negative cash flows from our operations. We have funded our operations primarily through the sale of equity. From inception through March 31, 2025, we raised an aggregate of CHF 355.4 million of gross proceeds from the sale of equity. We have also raised gross proceeds of CHF 5.0 million and acquired a 20% equity interest in Neurosterix US Holdings LLC as part of the Neurosterix Transaction executed on April 2, 2024. As at March 31, 2025, we had CHF 2.8 million in cash and cash equivalents.

Our primary uses of cash are to fund operating expenses, which consist mainly of research and development expenditures and associated general and administrative costs. Cash used to fund operating expenses is impacted by the timing of when we pay these expenses, as reflected in the changes in our outstanding accounts payable and accrued expenses. We currently have no ongoing material financing commitments, such as lines of credit or guarantees.

In the medium and long term, we expect an increase of our expenses compared to the three-month period ended March 31, 2025, as we continue the development of our GABAB PAM chronic cough drug candidate, initiate further clinical trials and seek marketing approval for our drug candidates.

In addition, if we obtain marketing approval for any of our drug candidates, we expect to incur significant commercialization expenses related to program sales, marketing, manufacturing and distribution to the extent that such sales, marketing and distribution are not the responsibility of potential collaborators. Accordingly, we will need to obtain substantial additional funding in connection with our continuing operations. If we are unable to raise capital when needed or on attractive terms, we would be forced to delay, reduce or eliminate our research and development programs or future commercialization efforts.

**MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION**

**AND RESULTS OF OPERATIONS**

We expect our existing cash and cash equivalents at the issuance date of these unaudited condensed consolidated financial statements will enable us to fund our operating expenses and capital expenditure requirements through mid - June 2026. Our future viability is dependent on our ability to monetize our intellectual property portfolio and /or raise additional capital though public or private financings that may dilute existing shareholders. We have based this estimate on assumptions that may prove to be wrong, and we could utilize our available capital resources sooner than we currently expect. Our future capital requirements will depend on many factors, including:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· the scope, progress, results and costs of our ongoing and planned preclinical
study for our GABAB PAM chronic cough drug candidate;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· the timing and amount of milestone and royalty payments we may receive under
our license agreements;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· the extent to which we out-license, in-license, sell or acquire other drug
candidates and technologies;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· the number and development requirements of other drug candidates that we
may pursue;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· the costs, timing and outcome of regulatory review of our drug candidates;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· cost associated with finding alternative suppliers due to geopolitical events
such as the ongoing war in Ukraine;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· the costs associated with building out our operations; and

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;· the costs and timing of future commercialization activities, including drug
manufacturing, marketing, sales and distribution, for any of our drug candidates for which we receive marketing approval.

Identifying potential drug candidates and conducting preclinical studies and clinical trials is a time-consuming, expensive and uncertain process that takes many years to complete, and we may never generate the necessary data or results required to obtain marketing approval and achieve product sales. In addition, our drug candidates, if approved, may not achieve commercial success. Our revenue, if any, will be derived from sales of products that we do not expect to be commercially available for many years, if at all.

Until such time, if ever, as we can generate substantial product revenue, we may finance our cash needs through a combination of equity offerings, debt financings, collaborations, strategic alliances and licensing arrangements. To the extent that we raise additional capital through the sale of equity or convertible debt securities, your ownership interest will be diluted, and the terms of any additional securities may include liquidation or other preferences that adversely affect your rights as a shareholder. Debt financing, if available, may involve agreements that include covenants limiting or restricting our ability to take specific actions, such as incurring additional debt, making capital expenditures or declaring dividends.

If we raise funds through additional collaborations, strategic alliances or licensing arrangements with third parties, we may have to relinquish valuable rights to our technologies, future revenue streams, research programs or drug candidates or to grant licenses on terms that may not be favorable to us. If we are unable to raise additional funds through equity or debt financings when needed, we may be required to delay, limit, reduce or terminate our product development or future commercialization efforts or grant rights to develop and market drug candidates that we would otherwise prefer to develop and market ourselves.

The following table shows a summary of our cash flows of the continuing operations for the periods indicated:

---

| | | |
|:---|:---|:---|
|  | **For the three months ended<br> March 31,** | **For the three months ended<br> March 31,** |
|  | **2025** | **2024** |
|  | **(CHF in thousands)** | **(CHF in thousands)** |
| Net cash flows used in operating activities | (599) | (512) |
| Net cash flows from financing activities | 98 | 234 |
| **Net cash used in operating activities** | **(501)** | **(278)** |

---

**MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION**

**AND RESULTS OF OPERATIONS**

***Operating activities***

Net cash flows from or used in operating activities consist of the net loss from continuing operations adjusted for changes in net working capital (current assets less current liabilities), and for non-cash items such as depreciation, the value of share-based services and changes in post-employment benefits.

During the three-month period ended March 31, 2025, operating activities used CHF 0.6 million of cash primarily due to our net loss of CHF 1.5 million partially offset by non-cash items amounting to CHF 0.9 million primarily related to the share of the net loss of the Neurosterix Group.

During the three-month period ended March 31, 2024, operating activities used CHF 0.5 million of cash primarily due to our net loss from continuing operations of CHF 0.7 million partially offset for CHF 0.2 million of increased net working capital mainly due to decreased trade payables and accruals.

***Financing activities***

Net cash flows from financing activities, primarily consists of proceeds from the sale of equity securities.

During the three-month period ended March 31, 2025, net cash flows from financing activities amounted to CHF 0.1 million and primarily related to funds received in advance for the future sales of treasury shares.

During the three-month period ended March 31, 2024, net cash flows from financing activities amounted to CHF 0.2 million and primarily related to the net proceeds from the sale of treasury shares through our sale agency agreement with Kepler Cheuvreux.

**Off-Balance Sheet Arrangements**

As of the date of the discussion and analysis and during the period presented, we did not have, and we do not currently have, any off-balance sheet arrangements, as defined in the rules and regulations of the U.S. Securities and Exchange Commission.

**Critical Accounting Policies and Significant Judgments and Estimates**

Our management's discussion and analysis of our financial condition and results of operations is based on our unaudited interim condensed consolidated financial statements, which we have prepared in accordance with International Accounting Standard 34 Interim Financial Reporting as issued by the International Accounting Standards Board.

**Recent Accounting Pronouncements**

The adoption of IFRS standards as issued by the IASB and interpretations issued by the IFRS interpretations committee that are effective for the first time for the financial year beginning on or after January 1, 2025 had no material impact on our financial position or disclosures made in our unaudited interim condensed consolidated financial statements.

**JOBS Act Transition Period**

Subject to certain conditions, as an emerging growth company, we may rely on certain of these exemptions under the Jumpstart Our Business Startups Act of 2012, or the JOBS Act, including without limitation, (1) providing an auditor's attestation report on our system of internal controls over financial reporting pursuant to Section 404(b) of the Sarbanes-Oxley Act and (2) complying with any requirement that may be adopted by the Public Company Accounting Oversight Board regarding mandatory audit firm rotation or a supplement to the auditor's report providing additional information about the audit and the financial statements, known as the auditor discussion and analysis. We will remain an emerging growth company until the earlier to occur of (1) the last day of the fiscal year (a) December 31, 2025 (b) in which we have total annual gross revenues of at least USD 1.07 billion or (c) in which we are deemed to be a "large accelerated filer" under the rules of the U.S. Securities and Exchange Commission, which means the market value of our common shares that is held by non-affiliates exceeds USD 700 million as of the prior June 30, and (2) the date on which we have issued more than USD 1.0 billion in non-convertible debt during the prior three-year period.

## Exhibit 99.3

**Exhibit 99.3**

![](tm2518303d1_ex99-3img001.jpg)

**PRESS RELEASE**

**Addex Therapeutics Reports Q1 2025 Financial Results and Provides Corporate Update**

· **Strong cash position of CHF2.8 million at end of Q1 2025** 

· **GABAB PAM chronic cough candidate demonstrated robust anti-tussive activity in disease models** 

· **Regained rights to our phase 2 mGlu2 PAM asset, ADX71149** 

· **Indivior advanced GABAB PAM Substance use disorders program successfully through IND enabling studies** 

· **Entered option agreement with Sinntaxis for an exclusive license to intellectual property covering the use of mGlu5 NAM in brain injury recovery** 

**Ad Hoc Announcement Pursuant to Art. 53 LR**

**Geneva, Switzerland, June 19, 2025 -** <u>Addex Therapeutics</u> (SIX and Nasdaq: ADXN), a clinical-stage biopharmaceutical company focused on developing a portfolio of novel small molecule allosteric modulators for neurological disorders, today reported its Q1 2025 financial results and provided a corporate update.

"We have had a great start to 2025 both in terms of product development and achieving business milestones. Progress continues well and on track with our GABAB PAM drug candidate in chronic cough. Positive data from this program in multiple preclinical models was recently presented at the prestigious American cough conference. We have also regained rights to our Phase 2 mGlu2 PAM asset, ADX71149," said Tim Dyer, CEO of Addex. "Solidifying our position to use mGlu5 NAMs in brain injury, we entered an option agreement with Sinntaxis to gain access to additional intellectual property. Our plan is to explore further the clinical activity of dipraglurant in this indication. Finally, our partner, Indivior, indicated that they have advanced their GABAB PAM clinical candidate through IND enabling studies, providing additional validation of our allosteric modulation approach."

**Operating Highlights:**

· GABAB PAM chronic cough candidate demonstrated robust anti-tussive activity
in multiple models of disease

· Regained rights to our phase 2 mGlu2 PAM asset,
ADX71149

· Indivior advanced their GABAB PAM program for
substance use disorders successfully through IND enabling studies

· Entered option agreement with Sinntaxis for exclusive
license to intellectual property covering use of mGlu5 NAM in brain injury recovery

**Key Q1 2025 Financial Data**

---

| | | | |
|:---|:---|:---|:---|
| **CHF' thousands** | **Q1 2025** | **Q1 2024** | **Change** |
| Income | 71 | 235 | (164) |
| R&D expenses | (156) | (245) | 89 |
| G&A expenses | (521) | (778) | 257 |
| **Total operating loss** | **(606)** | **(788)** | **182** |
| Finance result, net | (19) | 53 | (72) |
| Share of net loss of associates | (848) |  | (848) |
| **Net loss from continuing operations** | **(1473)** | **(735)** | **(738)** |
| **Net loss from discontinued operations** | **-** | **(2352)** | **2352** |
| **Net loss for the period** | **(1473)** | **(3087)** | **1614** |
| Basic and diluted net loss per share: |  |  |  |
| From continuing operations | (0.01) | (0.01) |  |
| From discontinued operations |  | (0.02) | (0.02) |
| **Total basic and diluted net loss per share** | **(0.01)** | **(0.03)** | **(0.02)** |
| Net decrease in cash during the period | (517) | (2237) | 1720 |
| Cash and cash equivalents | 2825 | 1628 | 1197 |
| Shareholders' equity | 8296 | (1373) | 9669 |

---

**Financial Summary:**

Income decreased by CHF 0.2 million during the three-month period ended March 31, 2025 compared to the same period ended March 31, 2024, primarily due to the completion of the service agreement with Indivior on June 30, 2024.

R&D expenses decreased by CHF 0.1 million during three-month period ended March 31, 2025 compared to the same period ended March 31, 2024 primarily due to lower GABAB PAM outsourced R&D expenses as we successfully completed the research phase of our agreement with Indivior on June 30, 2024.

G&A expenses decreased by CHF 0.3 million during the three-month period ended March 31, 2025 compared to the same period ended March 31, 2024 primarily due to reduced legal fees.

Net loss decreased by CHF 1.6 million during the three-month period ended March 31, 2025 compared to the same period ended March 31, 2024, primarily due to the discontinued loss of CHF 2.4 million incurred during the three-month period ended March 31, 2024, related to activities divested on April 2, 2024, partially offset by the share of the net loss of Neurosterix Group incurred for CHF 0.9 million during the three-month period ended March 31, 2025.

Basic and diluted loss per share amounted to CHF 0.01 per share for the three-month period ended March 31, 2025 compared to a basic and diluted loss per share of CHF 0.03 for the same period ended March 31, 2024.

Cash and cash equivalents increased to CHF 2.8 million at March 31, 2025, compared to CHF 1.6 million at March 31, 2024. The increase of CHF 1.2 million between March 31, 2025 and March 31, 2024 is primarily due to the gross proceeds of CHF 5.0 million from the Neurosterix Transaction received in April 2024, partially offset by the cash used in operating activities.

**Q1 2025 Consolidated Financial Statements:**

The Q1 2025 financial report can be found on the Company's website in the investor/download section <u>here</u>.

**Conference Call Details:**

A conference call will be held today, June 19, 2025, at 16:00 CEST (15:00 BST / 10:00 EDT / 07:00 PDT) to review the financial results. Tim Dyer, Chief Executive Officer and Mikhail Kalinichev, Head of Translational Science will deliver a brief presentation followed by a Q&A session.

**Joining the Conference Call:**

1. Participants are required to register in advance of the conference using the link provided below. Upon
registering, each participant will be provided with Participant Dial-in numbers, and a unique Personal PIN.

2. In the 10 minutes prior to the call's start time, participants will need to use the conference access
information provided in the e-mail received at the point of registering. Participants may also use the call me feature instead of dialing
the nearest dial in number.

Webcast registration URL:

<u>https://edge.media-server.com/mmc/p/esgoorze</u>

Conference call registration URL:

<u>https://register-conf.media-server.com/register/BI6cb9bb203334429a891b86017ad16a73</u>

**About Addex Therapeutics**

<u>Addex Therapeutics</u> is a clinical-stage biopharmaceutical company focused on developing a portfolio of novel small molecule allosteric modulators for neurological disorders. Addex's lead drug candidate, dipraglurant (mGlu5 negative allosteric modulator or NAM), is under evaluation for future development in brain injury recovery, including post-stroke and traumatic brain injury recovery. Addex's partner, Indivior, has selected a GABAB PAM drug candidate for development in substance use disorders and has successfully completed IND enabling studies. Addex is advancing an independent GABAB PAM program for chronic cough. Addex also holds a 20% equity interest in a private spin out company, Neurosterix LLC, which is advancing a portfolio of allosteric modulator programs, including M4 PAM for schizophrenia, mGlu7 NAM for mood disorders and mGlu2 NAM for mild neurocognitive disorders. Addex shares are listed on the SIX Swiss Exchange and American Depositary Shares representing its shares are listed on the NASDAQ Capital Market, and trade under the ticker symbol "ADXN" on each exchange. For more information, visit <u>www.addextherapeutics.com</u>

**Contacts:**

---

| | |
|:---|:---|
| Tim Dyer | Mike Sinclair |
| Chief Executive Officer | Partner, Halsin Partners |
| Telephone: +41 22 884 15 55 | +44 (0)7968 022075 |
| <u>PR@addextherapeutics.com</u> | <u>msinclair@halsin.com</u> |

---

**Addex Forward Looking Statements:**

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including statements about the intended use of proceeds of the offering. The words "may," "will," "could," "would," "should," "expect," "plan," "anticipate," "intend," "believe," "estimate," "predict," "project," "potential," "continue," "target" and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release, are based on management's current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, uncertainties related to market conditions. These and other risks and uncertainties are described in greater detail in the section entitled "Risk Factors" in Addex Therapeutics' Annual Report on Form 20-F, prospectus and other filings that Addex Therapeutics may make with the SEC in the future. Any forward-looking statements contained in this press release represent Addex Therapeutics' views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date. Addex Therapeutics explicitly disclaims any obligation to update any forward-looking statements.