# EDGAR Filing Document

**Accession Number:** 0001576280
**File Stem:** 0001193125-26-060468
**Filing Date:** 2026-2
**Character Count:** 19665
**Document Hash:** bd68ce2eb969e43d16ed113f0e15a814
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001193125-26-060468.hdr.sgml**: 20260220

**ACCESSION NUMBER**: 0001193125-26-060468

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 18

**FILED AS OF DATE**: 20260220

**DATE AS OF CHANGE**: 20260220

**EFFECTIVENESS DATE**: 20260220

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Guardant Health, Inc.
- **CENTRAL INDEX KEY:** 0001576280
- **STANDARD INDUSTRIAL CLASSIFICATION:** SERVICES-MEDICAL LABORATORIES [8071]
- **ORGANIZATION NAME:** 08 Industrial Applications and Services
- **EIN:** 454139254
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-293614
- **FILM NUMBER:** 26656864

**BUSINESS ADDRESS:**
- **STREET 1:** 3100 HANOVER STREET
- **CITY:** PALO ALTO
- **STATE:** CA
- **ZIP:** 94304
- **BUSINESS PHONE:** 855-698-8887

**MAIL ADDRESS:**
- **STREET 1:** 3100 HANOVER STREET
- **CITY:** PALO ALTO
- **STATE:** CA
- **ZIP:** 94304

**As filed with the Securities and Exchange Commission on February 20, 2026** 

**Registration No. 333-** 

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION** 

**Washington, D.C. 20549** 

**FORM S-8**

**REGISTRATION STATEMENT** 

***UNDER***

***THE SECURITIES ACT OF 1933***

## Guardant Health, Inc.
**(Exact name of Registrant as specified in its charter)** 

---

| | |
|:---|:---|
| **Delaware** | **45-4139254** |
| **(State or other jurisdiction of**<br> **incorporation or organization)** | **(I.R.S. Employer**<br> **Identification Number)** |
| **3100 Hanover Street**<br> **Palo Alto, California** | **94304** |
| **(Address of Principal Executive Offices)** | **(Zip Code)** |

---

**2018 Incentive Award Plan** 

**2018 Employee Stock Purchase Plan** 

**(Full Title of the Plan)** 

**John Saia** 

**Chief Legal Officer and Corporate Secretary** 

**3100 Hanover Street** 

**Palo Alto, California, 94304** 

**(855) 698-8887**

**(Name, address, including zip code, and telephone number, including area code, of agent for service)** 

***Copies to:***

**Andrew Thorpe, Esq.** 

**Elena Vespoli, Esq.** 

**Gunderson Dettmer Stough Villeneuve** 

**Franklin & Hachigian, LLP** 

**One Bush Plaza** 

**Suite 1200** 

**San Francisco, California 94104** 

**Tel: (415) 978-9803**

**Fax: (415) 978-9806**

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | ☒ | Accelerated filer | ☐ |
| Non-accelerated filer | ☐ | Smaller reporting company | ☐ |
|  |  | Emerging growth company | ☐ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

------

**EXPLANATORY NOTE** 

This Registration Statement on Form S-8 is being filed with the Securities and Exchange Commission (the "Commission") for the purpose of registering an aggregate of an additional 4,795,700 shares of common stock of the Registrant issuable under the following employee benefit plans for which registration statements (File Nos. 333-227762, 333-236807, 333-253733, 333-263105, 333-270241, 333-277312 and 333-285168) of the Registrant on Form S-8 (the "Registration Statements") are effective: (i) the Guardant Health, Inc. 2018 Incentive Award Plan which, as a result of the operation of an automatic annual increase provision therein, added 3,689,000 shares of common stock and (ii) the Guardant Health, Inc. 2018 Employee Stock Purchase Plan which, as a result of the operation of an automatic annual increase provision therein, added 1,106,700 shares of common stock.

**INCORPORATION BY REFERENCE OF CONTENTS OF REGISTRATION STATEMENTS ON** 

**FORM S-8**

Pursuant to General Instruction E of Form S-8, the contents of the Registration Statements on Form S-8 filed with the Commission on October 10, 2018 ([<u>File No.</u> <u>333-227762</u>](http://www.sec.gov/Archives/edgar/data/1576280/000162828018012409/guardantforms-8.htm)), March 2, 2020 ([<u>File No.</u> <u>333-236807</u>](http://www.sec.gov/Archives/edgar/data/1576280/000162828020002615/guardant-sx8.htm)), March 1, 2021 ([<u>File No.</u> <u>333-253733</u>](http://www.sec.gov/Archives/edgar/data/1576280/000157628021000034/guardants-8x2021.htm)), February 28, 2022 ([<u>File No.</u> <u>333-263105</u>](http://www.sec.gov/Archives/edgar/data/1576280/000119312522058272/d235781ds8.htm)), March 2, 2023 ([<u>File No.</u> <u>333-270241</u>](http://www.sec.gov/Archives/edgar/data/1576280/000119312523058325/d372938ds8.htm)), February 23, 2024 (File No.[333-277312](http://www.sec.gov/Archives/edgar/data/1576280/000119312524044500/d753017ds8.htm)) and February 24, 2025 (File No.[333-285168](http://www.sec.gov/Archives/edgar/data/1576280/000119312525033400/d929918ds8.htm)) are incorporated by reference herein.

------

**EXHIBIT INDEX** 

---

| | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|
| **Exhibit**<br>**Number** | | **Incorporated by Reference** | **Incorporated by Reference** | **Incorporated by Reference** | **Incorporated by Reference** | **Filed**<br> **Herewith** |
| **Exhibit**<br>**Number** | <br>**Exhibit Description** | **Form** | **Date** | **Exhibit** | **File Number** | **Filed**<br> **Herewith** |
| 4.1 | [Amended and Restated Certificate of Incorporation.](http://www.sec.gov/Archives/edgar/data/1576280/000162828018012404/exhibit318-k.htm) | 8-K | 10-9-18 | 3.1 | 001-38683 |  |
| 4.2 | [Amended and Restated Bylaws.](http://www.sec.gov/Archives/edgar/data/1576280/000162828018012404/exhibit328-k.htm) | 8-K | 10-9-18 | 3.2 | 001-38683 |  |
| 5.1 | [Opinion of Gunderson Dettmer Stough Villeneuve Franklin & Hachigian, LLP.](d59825dex51.htm) |  |  |  |  | X |
| 10.1 | [2018 Incentive Award Plan.](http://www.sec.gov/Archives/edgar/data/1576280/000162828018012409/exhibit992as-8.htm) | S-8 | 10-10-18 | 99.2(a) | 333-227762 |  |
| 10.2 | [Form of Stock Option Agreement under the 2018 Incentive Award Plan.](http://www.sec.gov/Archives/edgar/data/0001576280/000157628024000190/gh-06302024x10qxex102.htm) | 10-Q | 8-7-24 | 10.2 | 001-38683 |  |
| 10.3 | [Form of Restricted Stock Award Agreement under the 2018 Incentive Award Plan.](http://www.sec.gov/Archives/edgar/data/1576280/000162828018012029/exhibit109bsa2.htm) | S-1/A | 9-21-18 | 10.9(b) | 333-227206 |  |
| 10.4 | [Form of Restricted Stock Unit Award Agreement under the 2018 Incentive Award Plan.](http://www.sec.gov/Archives/edgar/data/1576280/000157628024000190/gh-06302024x10qxex103.htm) | 10-Q | 8-7-24 | 10.3 | 001-38683 |  |
| 10.5 | [Forms of Performance-Based Restricted Stock Unit Award Agreement under the 2018 Incentive Award Plan.](http://www.sec.gov/Archives/edgar/data/1576280/000157628024000190/gh-06302024x10qxex104.htm) | 10-Q | 8-7-24 | 10.4 | 001-38683 |  |
| 10.6 | [2018 Employee Stock Purchase Plan.](http://www.sec.gov/Archives/edgar/data/1576280/000162828018012409/exhibit993s-8.htm) | S-8 | 10-10-18 | 99.3 | 333-227762 |  |
| 10.7 | [First Amendment to 2018 Employee Stock Purchase Plan.](http://www.sec.gov/Archives/edgar/data/1576280/000162828019003139/gh-12312018x10kxexhibit104a.htm) | 10-K | 3-29-19 | 10.4(a) | 001-38683 |  |
| 23.1 | [Consent of Deloitte & Touche LLP, Independent Registered Public Accounting Firm.](d59825dex231.htm) |  |  |  |  | X |
| 23.2 | [Consent of Gunderson Dettmer Stough Villeneuve Franklin & Hachigian, LLP (included in Exhibit 5.1).](d59825dex51.htm) |  |  |  |  | X |
| 24.1 | [Power of Attorney (incorporated by reference to the signature page hereto).](#sig) |  |  |  |  | X |
| 107 | [Filing Fee Table.](d59825dexfilingfees.htm) |  |  |  |  | X |

---

------

**SIGNATURES** 

Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in Palo Alto, California, on February 20, 2026.

---

| | |
|:---|:---|
| **Guardant Health, Inc.** | **Guardant Health, Inc.** |
| By: | /s/ Michael Bell |
|  | Michael Bell |
|  | *Chief Financial Officer* |

---

**POWER OF ATTORNEY** 

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below does hereby constitute and appoint Helmy Eltoukhy, AmirAli Talasaz and Michael Bell and each of them, with full power of substitution and full power to act without the other, his or her true and lawful attorney-in-fact and agent to act for him or her in his or her name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this registration statement, and to file this registration statement, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in order to effectuate the same as fully, to all intents and purposes, as they or he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statement has been signed by the following persons in the capacities and on the date indicated.

------

---

| | | |
|:---|:---|:---|
| **Signature** | **Title** | **Date** |
|  /s/ Helmy Eltoukhy<br> Helmy Eltoukhy | Co-Chief Executive Officer<br> (Principal Executive Officer) and Chairman of the Board of Directors | February 20, 2026 |
|  /s/ AmirAli Talasaz<br> AmirAli Talasaz | Co-Chief Executive Officer<br> (Principal Executive Officer) and Director | February 20, 2026 |
|  /s/ Michael Bell<br> Michael Bell | Chief Financial Officer<br> (Principal Accounting Officer and Principal Financial Officer) | February 20, 2026 |
|  /s/ Ian Clark<br> Ian Clark | Director | February 20, 2026 |
|  /s/ Alex M. Azar II<br> Alex M. Azar II | Director | February 20, 2026 |
|  /s/ Vijaya Gadde<br> Vijaya Gadde | Director | February 20, 2026 |
|  /s/ Meghan Joyce<br> Meghan Joyce | Director | February 20, 2026 |
|  /s/ Steve Krognes<br> Steve Krognes | Director | February 20, 2026 |
|  /s/ Manuel Hidalgo Medina<br> Manuel Hidalgo Medina | Director | February 20, 2026 |
|  /s/ Roberto Mignone<br> Roberto Mignone | Director | February 20, 2026 |
|  /s/ Myrtle Potter | Director | February 20, 2026 |
|  Myrtle Potter |  |  |
|  /s/ Musa Tariq<br> Musa Tariq | Director | February 20, 2026 |

---

## Exhibit 5.1

**Exhibit 5.1** 

---

| | |
|:---|:---|
| ![LOGO](g59825dsp7a.jpg) | ![LOGO](g59825dsp7b.jpg) |

---

February 20, 2026

Guardant Health, Inc.

3100 Hanover Street

Palo Alto, CA 94304

Ladies and Gentlemen:

We refer to the registration statement on Form S-8 (the "Registration Statement") to be filed by Guardant Health, Inc., a Delaware corporation (the "Company"), with the Securities and Exchange Commission (the "Commission") in connection with the registration under the Securities Act of 1933, as amended (the "Act"), of an aggregate of 4,795,700 shares of the Company's common stock, par value $0.00001 per share (the "Shares"), that are subject to issuance by the Company (i) upon the exercise or settlement of awards granted or to be granted under the Company's 2018 Incentive Award Plan and (ii) upon the exercise of purchase rights to acquire Shares under the Company's 2018 Employee Stock Purchase Plan. The Company's 2018 Incentive Award Plan and the Company's 2018 Employee Stock Purchase Plan are collectively referred to in this letter as the "Plans."

In connection with this opinion, we have reviewed the actions proposed to be taken by you in connection with the issuance and sale of the Shares to be issued under the Plans. We have also examined and relied upon the Registration Statement and the originals or copies certified to our satisfaction of such other documents, records, certificates, memoranda and other instruments as in our judgment are necessary or appropriate to enable us to render the opinion expressed below. With your consent, we have relied upon certificates and other assurances of officers of the Company as to factual matters without having independently verified such factual matters. We have assumed the genuineness and authenticity of all documents submitted to us as originals, and the conformity to originals of all documents submitted to us as copies thereof and the due execution and delivery of all documents where due execution and delivery are a prerequisite to the effectiveness thereof.

This opinion is being furnished in connection with the requirements of Item 601(b)(5) of Regulation S-K under the Act, and no opinion is expressed herein as to any matter pertaining to the contents of the Registration Statement, other than as expressly stated herein with respect to the issue of the Shares. Our opinion is limited to the matters stated herein and no opinion is implied or may be inferred beyond the matters expressly stated. Our opinion herein is expressed solely with respect to the federal laws of the United States and the General Corporation Law of the State of Delaware. Our opinion is based on these laws as in effect on the date hereof, and we disclaim any obligation to advise you of facts, circumstances, events or developments which hereafter may be brought to our attention and which may alter, affect or modify the opinion expressed herein. We are not rendering any opinion as to compliance with any federal or state antifraud law, rule or regulation relating to securities, or to the sale or issuance thereof.

![LOGO](g59825g0218030724611.jpg)

![LOGO](g59825g0218030725368.jpg)

------

Based upon and subject to the foregoing, we advise you that, in our opinion, when the Shares have been issued pursuant to the applicable provisions of the Plans and pursuant to the agreements which accompany the Plans, and in accordance with the Registration Statement, such Shares will be validly issued, fully paid and nonassessable.

We hereby consent to the filing of this opinion as an exhibit to the Registration Statement. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Act or the rules and regulations of the Commission thereunder.

Very truly yours,

/s/ Gunderson Dettmer Stough Villeneuve Franklin & Hachigian, LLP

GUNDERSON DETTMER STOUGH

VILLENEUVE FRANKLIN & HACHIGIAN, LLP

## Exhibit 23.1

**Exhibit 23.1** 

**CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM** 

We consent to the incorporation by reference in this Registration Statement on Form S-8 of our reports dated February 19, 2026, relating to the financial statements of Guardant Health, Inc. and the effectiveness of Guardant Health Inc.'s internal control over financial reporting, appearing in the Annual Report on Form 10-K of Guardant Health, Inc. for the year ended December 31, 2025.

---

| |
|:---|
| /s/ Deloitte & Touche LLP |
| San Jose, California |
| February 20, 2026 |

---

## Ex-Filing

?xml version='1.0' encoding='ASCII'? EX-FILING FEES

---

| |
|:---|
| **Calculation of Filing Fee Tables**  |
| &nbsp;&nbsp;&nbsp;&nbsp;**S-8**  |
| &nbsp;&nbsp;&nbsp;&nbsp;**Guardant Health, Inc.**  |

---

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| | | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|:---|
| | **Security Type**  | **Security Class Title**  | **Fee Calculation Rule**  | **Amount Registered**  | **Proposed Maximum Offering Price Per Unit**  | **Maximum Aggregate Offering Price**  | **Fee Rate**  | **Amount of Registration Fee**  |
| 1 | Equity | Common Stock, $0.0001 par value per share, reserved for issuance pursuant to the 2018 Incentive Award Plan | Other | 3689000 | $104.40 | $385131600.00 | 0.0001381 | $53186.68 |
| 2 | Equity | Common Stock, $0.0001 par value per share, reserved for issuance pursuant to the 2018 Employee Stock Purchase Plan | Other | 1106700 | $88.74 | $98208558.00 | 0.0001381 | $13562.61 |
| Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: | Total Offering Amounts: |  | $483340158.00  |  | $66749.29  |
| Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  | Total Fee Offsets:  |  |  |  | $0.00  |
| Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  | Net Fee Due:  |  |  |  | $66749.29  |

---

 **Offering Note** <br>

<sup>1</sup> Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement shall also cover any additional shares of the Registrant's common stock that become issuable in respect of the securities identified in the above table by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the Registrant's receipt of consideration that increases the number of the outstanding shares of the Registrant's common stock. Represents additional shares of common stock reserved for issuance under the Registrant's 2018 Incentive Award Plan (the "2018 Plan") resulting from the annual automatic increase in the number of authorized shares reserved for issuance under the 2018 Plan. The increase was effective as of January 1, 2026. Estimated under Rules 457(c) and (h) of the Securities Act solely for the purpose of calculating the registration fee on the basis of the average of the high and low prices of the Registrant's common stock as quoted by The Nasdaq Global Market on February 12, 2026, which date is within five business days prior to the filing of the Registration Statement.

<sup>2</sup> Pursuant to Rule 416(a) under the Securities Act, this Registration Statement shall also cover any additional shares of the Registrant's common stock that become issuable in respect of the securities identified in the above table by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the Registrant's receipt of consideration that increases the number of the outstanding shares of the Registrant's common stock. Represents additional shares of common stock reserved for issuance under the Registrant's 2018 Employee Stock Purchase Plan (the "2018 ESPP") resulting from the annual automatic increase in the number of authorized shares reserved for issuance under the 2018 ESPP. The increase was effective as of January 1, 2026. Estimated under Rules 457(c) and (h) of the Securities Act solely for the purpose of calculating the registration fee on the basis of the average of the high and low prices of the Registrant's common stock as quoted by The Nasdaq Global Market on February 12, 2026, which date is within five business days prior to the filing of the Registration Statement, multiplied by 85%, which is the percentage of the trading price per share applicable to purchasers under the 2018 ESPP.

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| | |
|:---|:---|
| | |
| **Rule 457(p)** | **Rule 457(p)** |
| Fee Offset Claims | N/A |
| Fee Offset Sources | N/A |

---