# EDGAR Filing Document

**Accession Number:** 0001129928
**File Stem:** 0001104659-26-038540
**Filing Date:** 2026-4
**Character Count:** 2221
**Document Hash:** 183d4402dd2c8ad12985b4c267930f33
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001104659-26-038540.hdr.sgml**: 20260501

**ACCESSION NUMBER**: 0001104659-26-038540

**CONFORMED SUBMISSION TYPE**: CORRESP

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20260401

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** ONCOLYTICS BIOTECH INC
- **CENTRAL INDEX KEY:** 0001129928
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 980541667
- **STATE OF INCORPORATION:** NV
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** CORRESP

**BUSINESS ADDRESS:**
- **STREET 1:** SUITE 325, 4350 EXECUTIVE DRIVE
- **CITY:** SAN DIEGO
- **STATE:** CA
- **ZIP:** 92121
- **BUSINESS PHONE:** 4036707377

**MAIL ADDRESS:**
- **STREET 1:** SUITE 325, 4350 EXECUTIVE DRIVE
- **CITY:** SAN DIEGO
- **STATE:** CA
- **ZIP:** 92121

**ONCOLYTICS BIOTECH INC.**

**4350 Executive Drive, Suite 325**

**San Diego, California 92121**

**<u>VIA EDGAR</u>**

April 1, 2026

United States Securities and Exchange Commission

Division of Corporation Finance

Office of Life Sciences

100 F Street, N.E.

Washington, D.C. 20549

Attention: Tim Buchmiller

Re: Oncolytics Biotech Inc.

Registration Statement on Form S-3

Filed April 1, 2026

File No. 333-294811

To the addressee set forth above:

Pursuant to Rule 461 of the U.S. Securities Act of 1933, as amended, Oncolytics Biotech Inc. (the "Company") hereby requests acceleration of the effective date of its registration statement on Form S-3 (File No. 333-294811) (the "Registration Statement") to 4:30 p.m. Eastern Time on April 3, 2026, or as soon thereafter as practicable.

Please contact Christopher J. Clark of Latham & Watkins LLP, counsel to the Company, at (202) 637-2374 or Christopher.J.Clark@lw.com, as soon as the Registration Statement has been declared effective, or if you have any other questions or concerns regarding this matter.

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| | |
|:---|:---|
| Very truly yours, | Very truly yours, |
| ONCOLYTICS BIOTECH INC. | ONCOLYTICS BIOTECH INC. |
| By: | /s/ Kirk Look |
| Name: | Kirk Look |
| Title: | Chief Financial Officer |

---

cc: Jared Kelly, Chief Executive Officer

Christopher J. Clark, Latham & Watkins LLP