# EDGAR Filing Document

**Accession Number:** 0001501134
**File Stem:** 0001501134-23-000022
**Filing Date:** 2023-2
**Character Count:** 41201
**Document Hash:** da8cd283a71040c298cff924772d8e23
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001501134-23-000022.hdr.sgml**: 20230228

**ACCESSION NUMBER**: 0001501134-23-000022

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 15

**CONFORMED PERIOD OF REPORT**: 20230228

**ITEM INFORMATION**: Results of Operations and Financial Condition

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20230228

**DATE AS OF CHANGE**: 20230228

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Invitae Corp
- **CENTRAL INDEX KEY:** 0001501134
- **STANDARD INDUSTRIAL CLASSIFICATION:** SERVICES-MEDICAL LABORATORIES [8071]
- **IRS NUMBER:** 271701898
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-36847
- **FILM NUMBER:** 23685788

**BUSINESS ADDRESS:**
- **STREET 1:** 1400 16TH STREET
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94103
- **BUSINESS PHONE:** (415) 374-7782

**MAIL ADDRESS:**
- **STREET 1:** 1400 16TH STREET
- **CITY:** SAN FRANCISCO
- **STATE:** CA
- **ZIP:** 94103

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** InVitae Corp
- **DATE OF NAME CHANGE:** 20121105

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Locus Development Inc
- **DATE OF NAME CHANGE:** 20100910

?xml version="1.0" ? nvta-20230228

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

**Form 8-K**<br>

**CURRENT REPORT** 

**Pursuant to Section 13 or 15(d)**

**of the Securities Exchange Act of 1934** 

**Date of Report: February 28, 2023** 

**(Date of earliest event reported)**![nvta-20230228_g1.jpg](nvta-20230228_g1.jpg)

---

| |
|:---|
| **Invitae Corporation** |
| **(Exact name of the registrant as specified in its charter)** |

---

---

| | | |
|:---|:---|:---|
| **Delaware** | **001-36847** | **27-1701898** |
| **(State or other jurisdiction of** | **(Commission** | **(I.R.S. employer** |
| **incorporation or organization)** | **File Number)** | **identification number)** |

---

**1400 16th Street, San Francisco, California 94103** 

**(Address of principal executive offices, including zip code)** 

**(415) 374-7782**

**(Registrant's telephone number, including area code)** 

**N/A** 

**(Former Name or Former Address, if Changed Since Last Report)** 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

**Securities registered pursuant to Section 12(b) of the Act:**

---

| | | |
|:---|:---|:---|
| **Title of each class** | **Trading Symbol** | **Name of exchange on which registered** |
| Common Stock, $0.0001 par value per share | NVTA | New York Stock Exchange |

---

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

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---

| | |
|:---|:---|
| **Item 2.02** | **Results of Operations and Financial Condition.** |

---

On February 28, 2023, Invitae Corporation (the "Company") issued a press release announcing financial results for its fiscal quarter and year ended December 31, 2022. The full text of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K.

The information in Item 2.02 of this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be filed for purposes of Section 18 of the Securities Exchange Act of 1934 (the "Exchange Act"), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933 or the Exchange Act, except as shall be expressly set forth by specific reference in such filing.

---

| | |
|:---|:---|
| **Item 9.01** | **Financial Statements and Exhibits.** |

---

(d) Exhibits

---

| | |
|:---|:---|
| **Exhibit No.** | **Description** |
| <u>[99.1](a991pressreleaseforearning.htm)</u> | Press release issued by Invitae Corporation dated February 28, 2023 |
| 104 | Cover Page Interactive Data File (embedded within the Inline XBRL document). |

---

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**SIGNATURE** 

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Dated: February 28, 2023

---

| | |
|:---|:---|
| INVITAE CORPORATION | INVITAE CORPORATION |
| By: | /s/ Yafei (Roxi) Wen |
| Name: | Yafei (Roxi) Wen |
| Title: | Chief Financial Officer |

---

## Exhibit 99.1

![invitaelogoa02.jpg](invitaelogoa02.jpg)

**Invitae Reports Fourth Quarter and Full Year 2022 Financial Results; Provides Company Updates**

– Entered into a ~$336 million transaction for the 2024 convertible notes, effectively addressing ~96% of the amount outstanding (see separate press release to follow) –

– Repaid its 2024 senior secured term loan in full, improving its balance sheet –

– Company maintains cash runway through the end of 2024 –

– Annual revenue grew by 12.1%; Continued to improve on key financial metrics –

– Major initiatives under strategic realignment largely completed –

– Guiding to low double digit pro forma revenue growth and continued expansion of non-GAAP gross margin in 2023, decreasing cash burn by over 45% from 2022 –

– Conference call and webcast today at 4:30 p.m. Eastern Time / 1:30 p.m. Pacific Time –

**SAN FRANCISCO – February 28, 2023** – Invitae (NYSE: NVTA), a leading medical genetics company, today announced financial and operating results for the fourth quarter and year ended December 31, 2022.

"2022 was a transformative year for Invitae as we shifted our focus to drive more profitable growth, and we are pleased that the major initiatives under our strategic realignment are now largely completed," said Ken Knight, president and chief executive officer of Invitae. "Our talented teams made great progress, and continued their work in service of patients and customers while delivering on the financial objectives aligned to our new path. These continued improvements in our financial metrics reflect our new priorities and operating discipline. In light of that execution, we separately announced today significant developments in addressing approximately 96% of our near-term debt obligations. Our investors have agreed to extend the maturities of our 2024 convertible notes into 2028, along with equitizing a portion of the debt and adding capital, demonstrating their confidence in Invitae's future. We have also repaid our term loan in full and further improved our balance sheet. Overall, we are looking forward to 2023, as we continue to drive operational excellence, along with setting the stage for our long-term growth opportunities for years to come."

**Full Year and Fourth Quarter 2022 Financial Results**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Generated revenue of $516.3 million in 2022, a 12.1% increase from $460.4 million in 2021. Fourth quarter 2022 revenue of $122.5 million, versus $126.1 million a year ago, reflecting the impact of exited businesses and geographies announced earlier in the year.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• GAAP gross profit was $99.1 million in 2022, including $29.6 million in the fourth quarter. Non-GAAP gross profit was $219.7 million in 2022, including $58.5 million in the fourth quarter.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• GAAP gross margin was 19.2% in 2022, as compared with 24.3% in 2021, and 24.2% in the fourth quarter of 2022, versus 23.8% in the fourth quarter of 2021. Non-GAAP gross margin was 42.5% in 2022, as compared with 36.6% in 2021. Non-GAAP gross margin was 47.8% in the fourth quarter of 2022, compared to 36.5% in the fourth quarter of 2021.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Cash, cash equivalents, restricted cash and marketable securities were $557.1 million as of December 31, 2022, compared to $596.0 million as of September 30, 2022 and $1.06 billion as of December 31, 2021.

------

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Cash burn in 2022 was $509.6 million, compared to a cash burn of $849.2 million in 2021. 2022 cash burn included outflows of $53.3 million ($38.4 million related to realignment and $14.9 million acquisition-related payments), as well as an inflow of $44.5 million related to the selected assets sale of the RUO kitted solutions.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Cash burn in the fourth quarter was $41.8 million and included an outflow of $9.3 million related to realignment and $0.1 million of acquisition-related payments, as well as an inflow of $44.5 million related to the selected assets sale of the RUO kitted solutions. Excluding these items, cash burn would have been $77.0 million. This represents a continued improving trend since the fourth quarter of 2021 driven by our strategic realignment and cost reduction plans.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Total active healthcare provider accounts totaled 20,929 as of December 31, 2022, an increase of approximately 13% year-over-year.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Active pharmaceutical and commercial partnerships grew to 238, an increase of approximately 34% year-over-year, reflecting growing adoption of our product and services to pharmaceutical, health systems and other partners.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Revenue per patient was $475 in 2022, a decrease of approximately 3% from $491 in 2021. Revenue per patient was $511 in the fourth quarter of 2022, compared to $505 in the third quarter of 2022, and $476 in the fourth quarter of 2021, primarily as a result of our realignment efforts.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Total patient population as of December 31, 2022 is more than 3.6 million with over 62% available for data sharing.

Total GAAP operating expense, which excludes cost of revenue, for the fourth quarter of 2022 was $124.5 million, which includes items related to the strategic realignment. As a result, GAAP operating expense as a percentage of revenue was 102%, compared to 194% in the fourth quarter of 2021. Non-GAAP operating expense was $135.6 million for the fourth quarter of 2022. Non-GAAP operating expense as a percentage of revenue was 111%, compared to 171% in the fourth quarter of 2021.

Net loss for the fourth quarter of 2022 was $99.8 million, or a $0.41 net loss per share, compared to net loss of $205.1 million, or net loss per share of $0.90, for the fourth quarter of 2021. Non-GAAP net loss for the fourth quarter of 2022 was $82.0 million, or a $0.34 non-GAAP net loss per share, compared to a net loss of $184.7 million, or an $0.81 non-GAAP net loss per share, for the fourth quarter of 2021.

**Financial Guidance**

On a pro forma basis, the company exited fourth quarter 2022 at an annualized revenue of approximately $450 million for its remaining business. Management is expecting 2023 revenue to be over $500 million, representing low double-digit year-over-year growth compared to 2022 pro forma revenue.

Thanks to realignment initiatives, non-GAAP gross margin for 2023 is expected to be between 48-50%, compared to 42.5% in 2022. Cash burn is expected to be in the range of $250-275 million in 2023, a more than 45% reduction from 2022.

**Webcast and Conference Call Details**

Management will host a conference call and webcast today at 4:30 p.m. Eastern Time / 1:30 p.m. Pacific Time to discuss financial results and recent developments. To access the conference call, please register at the link below:

https://www.netroadshow.com/events/login?show=d75171b5&confId=46549

Upon registering, each participant will be provided with call details and access codes.

The live webcast of the call and slide deck may be accessed here or by visiting the investors section of the company's website at ir.invitae.com. A replay of the webcast will be available shortly after the conclusion of the call and will be archived on the company's website.

------

**About Invitae**

Invitae (NYSE: NVTA) is a leading medical genetics company trusted by millions of patients and their providers to deliver timely genetic information using digital technology. We aim to provide accurate and actionable answers to strengthen medical decision-making for individuals and their families. Invitae's genetics experts apply a rigorous approach to data and research, serving as the foundation of their mission to bring comprehensive genetic information into mainstream medicine to improve healthcare for billions of people.

To learn more, visit invitae.com and follow for updates on Twitter, Instagram, Facebook and LinkedIn @Invitae.

**Safe Harbor Statements**

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements relating to the company's mission; the expected impact, benefits, and timing of the company's strategic business realignment or various aspects thereof; the company's expectations regarding future financial and operating results, and the drivers of future financial results; the company's roadmap for 2023 and long-term growth; and the company's expectations regarding the exchange and equitization of existing notes, extension of debt maturity and repayment of senior secured loans. Forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially and reported results should not be considered as an indication of future performance. These risks and uncertainties include, but are not limited to: the ability of the company to successfully execute its strategic business realignment and achieve the intended benefits thereof on the expected timeframe or at all; unforeseen or greater than expected costs associated with the strategic business realignment; the risk that the disruption that may result from the realignment may harm the company's business, market share or its relationship with customers or potential customers; satisfaction of closing conditions related to the debt exchange and equitization transaction; the impact of COVID-19 on the company, and the effectiveness of the efforts it has taken or may take in the future in response thereto; the impact of inflation and the current economic environment on the company's business; the company's ability to grow its business in a cost-efficient manner; the company's history of losses; the company's ability to maintain important customer relationships; the company's ability to compete; the company's failure to manage growth effectively; the company's need to scale its infrastructure in advance of demand for its tests and to increase demand for its tests; the risk that the company may not obtain or maintain sufficient levels of reimbursement for its tests; the applicability of clinical results to actual outcomes; risks associated with litigation; the company's ability to use rapidly changing genetic data to interpret test results accurately and consistently; laws and regulations applicable to the company's business; and the other risks set forth in the reports filed by the company with the SEC, including its Quarterly Report on Form 10-Q for the quarter ended September 30, 2022. These forward-looking statements speak only as of the date hereof, and Invitae Corporation disclaims any obligation to update these forward-looking statements.

**Non-GAAP Financial Measures**

To supplement the company's consolidated financial statements prepared in accordance with generally accepted accounting principles in the United States (GAAP), the company is providing several non-GAAP measures. These non-GAAP financial measures exclude certain items that are required by GAAP. In addition, these non-GAAP measures are not based on any standardized methodology prescribed by GAAP and are not necessarily comparable to similarly-titled measures presented by other companies. Management believes these non-GAAP financial measures are useful to investors in evaluating the company's ongoing operating results and trends. Management uses such non-GAAP information to manage the company's business and monitor its performance.

Other companies, including companies in the same industry, may not use the same non-GAAP measures or may calculate these metrics in a different manner than management or may use other financial measures to evaluate their performance, all of which could reduce the usefulness of these non-GAAP

------

measures as comparative measures. Because of these limitations, the company's non-GAAP financial measures should not be considered in isolation from, or as a substitute for, financial information prepared in accordance with GAAP. Investors are encouraged to review the non-GAAP reconciliations provided in the tables below and on the company's website.

In addition, this press release includes the company's non-GAAP gross margin guidance, a non-GAAP measure used to describe the company's expected performance. The company has not presented a reconciliation of this non-GAAP measure to the company's gross margin, the most comparable GAAP financial measure, because the reconciliation could not be prepared without unreasonable effort. The information necessary to prepare the reconciliation is not available on a forward-looking basis and cannot be accurately predicted. The unavailable information could have a significant impact on the calculation of the comparable GAAP financial measure.

------

**INVITAE CORPORATION**

**Consolidated Balance Sheets**

(in thousands)

---

| | | |
|:---|:---|:---|
| | **December 31,** | **December 31,** |
| | **2022** | **2021** |
| **Assets** |  |  |
| Current assets: |  |  |
| &nbsp;&nbsp;&nbsp;Cash and cash equivalents | $257489 | $923250 |
| &nbsp;&nbsp;&nbsp;Marketable securities | 289611 | 122121 |
| &nbsp;&nbsp;&nbsp;Accounts receivable | 96148 | 66227 |
| &nbsp;&nbsp;&nbsp;Inventory | 30386 | 33516 |
| &nbsp;&nbsp;&nbsp;Prepaid expenses and other current assets | 19496 | 33691 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total current assets | 693130 | 1178805 |
| Property and equipment, net | 108723 | 114714 |
| Operating lease assets | 106563 | 121169 |
| Restricted cash | 10030 | 10275 |
| Intangible assets, net | 1012549 | 1187994 |
| Goodwill |  | 2283059 |
| Other assets | 23121 | 23551 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total assets | $1954116 | $4919567 |
| **Liabilities and stockholders' equity** |  |  |
| Current liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;Accounts payable | $13984 | $21127 |
| &nbsp;&nbsp;&nbsp;Accrued liabilities | 74388 | 106453 |
| &nbsp;&nbsp;&nbsp;Operating lease obligations | 14600 | 12359 |
| &nbsp;&nbsp;&nbsp;Finance lease obligations | 5121 | 4156 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total current liabilities | 108093 | 144095 |
| Operating lease obligations, net of current portion | 134386 | 124369 |
| Finance lease obligations, net of current portion | 3780 | 5683 |
| Debt | 122333 | 113391 |
| Convertible senior notes, net | 1470783 | 1464138 |
| Deferred tax liability | 8130 | 51696 |
| Other long-term liabilities | 4775 | 37797 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total liabilities | 1852280 | 1941169 |
| Stockholders' equity: |  |  |
| &nbsp;&nbsp;&nbsp;Common stock | 25 | 23 |
| &nbsp;&nbsp;&nbsp;Accumulated other comprehensive loss | (80) | (7) |
| &nbsp;&nbsp;&nbsp;Additional paid-in capital | 4931032 | 4701230 |
| &nbsp;&nbsp;&nbsp;Accumulated deficit | (4829141) | (1722848) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total stockholders' equity | 101836 | 2978398 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total liabilities and stockholders' equity | $1954116 | $4919567 |

---

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**INVITAE CORPORATION**

**Consolidated Statements of Operations**

(in thousands, except per share data)

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended December 31,** | **Three Months Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
| | **2022** | **2021** | **2022** | **2021** |
| Revenue: |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Test revenue | $119042 | $121624 | $500560 | $444072 |
| &nbsp;&nbsp;&nbsp;&nbsp;Other revenue | 3412 | 4497 | 15743 | 16377 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total revenue | 122454 | 126121 | 516303 | 460449 |
| Operating expenses: |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Cost of revenue | 92844 | 96106 | 417256 | 348669 |
| &nbsp;&nbsp;&nbsp;&nbsp;Research and development | 71529 | 131764 | 402088 | 416087 |
| &nbsp;&nbsp;&nbsp;&nbsp;Selling and marketing | 46795 | 62205 | 218881 | 225910 |
| &nbsp;&nbsp;&nbsp;&nbsp;General and administrative | 43243 | 50430 | 192314 | 248070 |
| &nbsp;&nbsp;&nbsp;&nbsp;Goodwill and IPR&D impairment |  |  | 2313047 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring and other costs | 10292 |  | 140331 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Gain on sale of RUO kit assets | (47354) |  | (47354) |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in fair value of contingent consideration |  | 190 | (1850) | (386646) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total operating expenses | 217349 | 340695 | 3634713 | 852090 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Loss from operations | (94895) | (214574) | (3118410) | (391641) |
| Other income (expense), net: |  |  |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in fair value of acquisition-related liabilities | 240 | 16017 | 15906 | 25196 |
| &nbsp;&nbsp;&nbsp;&nbsp;Other income (expense), net | 4083 | (185) | 8054 | 482 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total other income, net | 4323 | 15832 | 23960 | 25678 |
| Interest expense | (14598) | (14031) | (56747) | (49900) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net loss before taxes | (105170) | (212773) | (3151197) | (415863) |
| Income tax benefit | 5353 | 7649 | 44904 | 36857 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net loss | $(99817) | $(205124) | $(3106293) | $(379006) |
| Net loss per share, basic and diluted | $(0.41) | $(0.90) | $(13.18) | $(1.80) |
| Shares used in computing net loss per share, basic and diluted | 243948 | 226849 | 235676 | 210946 |

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**INVITAE CORPORATION**

**Consolidated Statements of Cash Flows**

(in thousands)

---

| | | | |
|:---|:---|:---|:---|
| | **Year Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
| | **2022** | **2021** | **2020** |
| **Cash flows from operating activities:** |  |  |  |
| Net loss | $(3106293) | $(379006) | $(602170) |
| Adjustments to reconcile net loss to net cash used in operating activities: | Adjustments to reconcile net loss to net cash used in operating activities: | Adjustments to reconcile net loss to net cash used in operating activities: | Adjustments to reconcile net loss to net cash used in operating activities: |
| &nbsp;&nbsp;&nbsp;&nbsp;Goodwill and IPR&D impairment | 2313047 |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Impairments and losses on disposals of long-lived assets | 60507 |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Gain on sale of RUO kit assets | (47354) |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Depreciation and amortization | 142071 | 80472 | 39050 |
| &nbsp;&nbsp;&nbsp;&nbsp;Stock-based compensation | 199304 | 180075 | 158747 |
| &nbsp;&nbsp;&nbsp;&nbsp;Amortization of debt discount and issuance costs | 15587 | 14226 | 17204 |
| &nbsp;&nbsp;&nbsp;&nbsp;Remeasurements of liabilities associated with business combinations | (17756) | (411842) | 92348 |
| &nbsp;&nbsp;&nbsp;&nbsp;Benefit from income taxes | (44904) | (36857) | (112100) |
| &nbsp;&nbsp;&nbsp;&nbsp;Post-combination expense for acceleration of unvested equity and deferred stock compensation | 8428 | 9530 | 91021 |
| &nbsp;&nbsp;&nbsp;&nbsp;Amortization of premiums and discounts on investment securities | (1515) | 6221 | 1236 |
| &nbsp;&nbsp;&nbsp;&nbsp;Non-cash lease expense | 10240 | 3496 | 777 |
| &nbsp;&nbsp;&nbsp;&nbsp;Other | 1018 | 1487 | (588) |
| Changes in operating assets and liabilities, net of businesses acquired: | Changes in operating assets and liabilities, net of businesses acquired: | Changes in operating assets and liabilities, net of businesses acquired: | Changes in operating assets and liabilities, net of businesses acquired: |
| &nbsp;&nbsp;&nbsp;&nbsp;Accounts receivable | (29921) | (16696) | (2814) |
| &nbsp;&nbsp;&nbsp;&nbsp;Inventory | 3130 | (1486) | (7832) |
| &nbsp;&nbsp;&nbsp;&nbsp;Prepaid expenses and other current assets | 14195 | (14563) | (2010) |
| &nbsp;&nbsp;&nbsp;&nbsp;Other assets | 3124 | (3274) | 895 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accounts payable | (2465) | (9258) | 10186 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accrued expenses and other long-term liabilities | (13404) | 17660 | 17548 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net cash used in operating activities | (492961) | (559815) | (298502) |
| **Cash flows from investing activities:** |  |  |  |
| Purchases of marketable securities | (892361) | (325957) | (280258) |
| Proceeds from sales of marketable securities |  |  | 12832 |
| Proceeds from maturities of marketable securities | 726313 | 425293 | 277487 |
| Acquisition of businesses, net of cash acquired |  | (247396) | (383753) |
| Proceeds from sale of RUO kit assets | 44554 |  |  |
| Purchases of property and equipment | (53309) | (54720) | (22865) |
| Other |  | (1300) | (4026) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net cash used in investing activities | (174803) | (204080) | (400583) |
| **Cash flows from financing activities:** |  |  |  |
| Proceeds from public offerings of common stock, net | 9658 | 434263 | 263688 |
| Proceeds from issuance of common stock | 8157 | 23767 | 284203 |
| Proceeds from issuance of convertible senior notes, net |  | 1116427 |  |
| Proceeds from issuance of debt, net |  |  | 129214 |
| Finance lease principal payments | (5410) | (3759) | (2655) |
| Settlement of acquisition obligations | (10647) | (4758) | (1457) |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Net cash provided by financing activities | 1758 | 1565940 | 672993 |
| **Net (decrease) increase in cash, cash equivalents and restricted cash** | (666006) | 802045 | (26092) |
| **Cash, cash equivalents and restricted cash at beginning of period** | 933525 | 131480 | 157572 |
| **Cash, cash equivalents and restricted cash at end of period** | $267519 | $933525 | $131480 |

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**INVITAE CORPORATION**

**Reconciliation of GAAP to Non-GAAP Cost of Revenue**

(in thousands)

(unaudited)

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended December 31,** | **Three Months Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
| | **2022** | **2021** | **2022** | **2021** |
| Cost of revenue | $92844 | $96106 | $417256 | $348669 |
| &nbsp;&nbsp;&nbsp;&nbsp;Amortization of acquired intangible assets | (26950) | (15392) | (100568) | (49970) |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition-related stock-based compensation | (156) | (141) | (581) | (2461) |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition-related post-combination expense |  | (479) | (1053) | (1058) |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in fair value of acquisition-related assets |  |  |  | (3148) |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring-related retention bonuses | (82) |  | (252) |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Inventory and prepaid write-offs | (1712) |  | (18179) |  |
| Non-GAAP cost of revenue | $63944 | $80094 | $296623 | $292032 |

---

**Reconciliation of GAAP to Non-GAAP Gross Profit**

(in thousands)

(unaudited)

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended December 31,** | **Three Months Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
| | **2022** | **2021** | **2022** | **2021** |
| Revenue | $122454 | $126121 | $516303 | $460449 |
| Cost of revenue | 92844 | 96106 | 417256 | 348669 |
| Gross profit | 29610 | 30015 | 99047 | 111780 |
| &nbsp;&nbsp;&nbsp;&nbsp;Amortization of acquired intangible assets | 26950 | 15392 | 100568 | 49970 |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition-related stock-based compensation | 156 | 141 | 581 | 2461 |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition-related post-combination expense |  | 479 | 1053 | 1058 |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in fair value of acquisition-related assets |  |  |  | 3148 |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring-related retention bonuses | 82 |  | 252 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Inventory and prepaid write-offs | 1712 |  | 18179 |  |
| Non-GAAP gross profit | $58510 | $46027 | $219680 | $168417 |

---

**Reconciliation of GAAP to Non-GAAP Research and Development Expense**

(in thousands)

(unaudited)

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended December 31,** | **Three Months Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
| | **2022** | **2021** | **2022** | **2021** |
| Research and development | $71529 | $131764 | $402088 | $416087 |
| &nbsp;&nbsp;&nbsp;&nbsp;Amortization of acquired intangible assets | (91) | (529) | (1429) | (2117) |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition-related stock-based compensation | (14367) | (23703) | (80086) | (44406) |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition-related post-combination expense | (3460) | (2607) | (10646) | (6056) |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring-related retention bonuses | (1339) |  | (1985) |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring-related accelerated depreciation | (2607) |  | (5918) |  |
| Non-GAAP research and development | $49665 | $104925 | $302024 | $363508 |

---

------

**INVITAE CORPORATION**

**Reconciliation of GAAP to Non-GAAP Selling and Marketing Expense**

(in thousands)

(unaudited)

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended December 31,** | **Three Months Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
| | **2022** | **2021** | **2022** | **2021** |
| Selling and marketing | $46795 | $62205 | $218881 | $225910 |
| &nbsp;&nbsp;&nbsp;&nbsp;Amortization of acquired intangible assets | (1595) | (1686) | (6451) | (6748) |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition-related stock-based compensation | (511) |  | (2885) | (2696) |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition-related post-combination expense |  |  |  | (38) |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring-related retention bonuses | (243) |  | (358) |  |
| Non-GAAP selling and marketing | $44446 | $60519 | $209187 | $216428 |

---

**Reconciliation of GAAP to Non-GAAP General and Administrative Expense**

(in thousands)

(unaudited)

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended December 31,** | **Three Months Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
| | **2022** | **2021** | **2022** | **2021** |
| General and administrative | $43243 | $50430 | $192314 | $248070 |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition-related stock-based compensation | (1119) | (32) | (7775) | (21293) |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition-related post-combination expense |  | (165) |  | (35628) |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring-related retention bonuses | (595) |  | (895) |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring-related accelerated depreciation | (71) |  | (182) |  |
| Non-GAAP general and administrative | $41458 | $50233 | $183462 | $191149 |

---

**Reconciliation of Operating Expenses to Non-GAAP Operating Expenses**

(in thousands)

(unaudited)

---

| | | | | |
|:---|:---|:---|:---|:---|
|  | **Three Months Ended December 31,** | **Three Months Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
|  | **2022** | **2021** | **2022** | **2021** |
| Research and development | $71529 | $131764 | $402088 | $416087 |
| Selling and marketing | 46795 | 62205 | 218881 | 225910 |
| General and administrative | 43243 | 50430 | 192314 | 248070 |
| Goodwill and IPR&D impairment |  |  | 2313047 |  |
| Restructuring and other costs | 10292 |  | 140331 |  |
| Gain on sale of RUO kit assets | (47354) |  | (47354) |  |
| Change in fair value of contingent consideration |  | 190 | (1850) | (386646) |
| Operating expenses | 124505 | 244589 | 3217457 | 503421 |
| &nbsp;&nbsp;&nbsp;&nbsp;Goodwill and IPR&D impairment |  |  | (2313047) |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring and other costs | (10292) |  | (140331) |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Gain on sale of RUO kit assets | 47354 |  | 47354 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in fair value of contingent consideration |  | (190) | 1850 | 386646 |
| &nbsp;&nbsp;&nbsp;&nbsp;Amortization of acquired intangible assets | (1686) | (2215) | (7880) | (8865) |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition-related stock-based compensation | (15997) | (23735) | (90746) | (68395) |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition-related post-combination expense | (3460) | (2772) | (10646) | (41722) |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring-related retention bonuses | (2177) |  | (3238) |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring-related accelerated depreciation | (2678) |  | (6100) |  |
| Non-GAAP operating expenses | $135569 | $215677 | $694673 | $771085 |

---

------

**INVITAE CORPORATION**

**Reconciliation of Other Income, Net to Non-GAAP Other Income (Expense), Net**

(in thousands)

(unaudited)

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended December 31,** | **Three Months Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
| | **2022** | **2021** | **2022** | **2021** |
| Other income, net | $4323 | $15832 | $23960 | $25678 |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in fair value of acquisition-related liabilities | (240) | (16017) | (15906) | (25196) |
| Non-GAAP other income (expense), net | $4083 | $(185) | $8054 | $482 |

---

**Reconciliation of Net Loss to Non-GAAP Net Loss and Non-GAAP Net Loss Per Share**

(in thousands, except per share data)

(unaudited)

---

| | | | | |
|:---|:---|:---|:---|:---|
| | **Three Months Ended December 31,** | **Three Months Ended December 31,** | **Year Ended December 31,** | **Year Ended December 31,** |
| | **2022** | **2021** | **2022** | **2021** |
| Net loss | $(99817) | $(205124) | $(3106293) | $(379006) |
| &nbsp;&nbsp;&nbsp;&nbsp;Goodwill and IPR&D impairment |  |  | 2313047 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring and other costs | 10292 |  | 140331 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Gain on sale of RUO kit assets | (47354) |  | (47354) |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in fair value of contingent consideration |  | 190 | (1850) | (386646) |
| &nbsp;&nbsp;&nbsp;&nbsp;Amortization of acquired intangible assets | 28636 | 17607 | 108448 | 58835 |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition-related stock-based compensation | 16153 | 23876 | 91327 | 70856 |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition-related post-combination expense | 3460 | 3251 | 11699 | 42780 |
| &nbsp;&nbsp;&nbsp;&nbsp;Change in fair value of acquisition-related assets and liabilities | (240) | (16017) | (15906) | (22048) |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring-related retention bonuses | 2259 |  | 3490 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Restructuring-related accelerated depreciation | 2678 |  | 6100 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Inventory and prepaid write-offs | 1712 |  | 18179 |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Acquisition-related income tax benefit | 235 | (8480) | (39960) | (39087) |
| Non-GAAP net loss | $(81986) | $(184697) | $(518742) | $(654316) |
| Net loss per share, basic and diluted | $(0.41) | $(0.90) | $(13.18) | $(1.80) |
| Non-GAAP net loss per share, basic and diluted | $(0.34) | $(0.81) | $(2.20) | $(3.10) |
| Shares used in computing net loss per share, basic and diluted | 243948 | 226849 | 235676 | 210946 |

---

------

**INVITAE CORPORATION**

**Reconciliation of Net (Decrease) Increase in Cash, Cash Equivalents and Restricted Cash to Cash Burn**

(in thousands)

(unaudited)

---

| | | | | | |
|:---|:---|:---|:---|:---|:---|
| | **Three Months Ended** | **Three Months Ended** | **Three Months Ended** | **Three Months Ended** | |
| **TABLE11** | **March 31, 2022** | **June 30, 2022** | **September 30, 2022** | **December 31, 2022** | **Year Ended**<br>**December 31, 2022** |
| Net cash used in operating activities | $(147543) | $(134689) | $(128702) | $(82027) | $(492961) |
| Net cash (used in) provided by investing activities | (449456) | 108965 | 43797 | 121891 | (174803) |
| Net cash (used in) provided by financing activities | (920) | 3770 | (1691) | 599 | 1758 |
| Net (decrease) increase in cash, cash equivalents and restricted cash | (597919) | (21954) | (86596) | 40463 | (666006) |
| Adjustments: |  |  |  |  |  |
| &nbsp;&nbsp;&nbsp;Net changes in investments | 428608 | (125087) | (55212) | (82261) | 166048 |
| &nbsp;&nbsp;&nbsp;Proceeds from public offering of common stock, net |  |  | (9658) |  | (9658) |
| Cash burn | $(169311) | $(147041) | $(151466) | $(41798) | $(509616) |
| • Cash burn for the three months ended June 30, 2022 includes $0.7 million of acquisition-related payments. | • Cash burn for the three months ended June 30, 2022 includes $0.7 million of acquisition-related payments. | • Cash burn for the three months ended June 30, 2022 includes $0.7 million of acquisition-related payments. | • Cash burn for the three months ended June 30, 2022 includes $0.7 million of acquisition-related payments. | • Cash burn for the three months ended June 30, 2022 includes $0.7 million of acquisition-related payments. | • Cash burn for the three months ended June 30, 2022 includes $0.7 million of acquisition-related payments. |
| • Cash burn for the three months ended September 30, 2022 includes $29.1 million of restructuring-related cash payments and $14.1 million of acquisition-related payments. | • Cash burn for the three months ended September 30, 2022 includes $29.1 million of restructuring-related cash payments and $14.1 million of acquisition-related payments. | • Cash burn for the three months ended September 30, 2022 includes $29.1 million of restructuring-related cash payments and $14.1 million of acquisition-related payments. | • Cash burn for the three months ended September 30, 2022 includes $29.1 million of restructuring-related cash payments and $14.1 million of acquisition-related payments. | • Cash burn for the three months ended September 30, 2022 includes $29.1 million of restructuring-related cash payments and $14.1 million of acquisition-related payments. | • Cash burn for the three months ended September 30, 2022 includes $29.1 million of restructuring-related cash payments and $14.1 million of acquisition-related payments. |
| • Cash burn for the three months ended December 31, 2022 includes $44.5 million of proceeds from the sale of RUO kit assets, $9.3 million of restructuring-related cash payments and $0.1 million of acquisition-related payments. | • Cash burn for the three months ended December 31, 2022 includes $44.5 million of proceeds from the sale of RUO kit assets, $9.3 million of restructuring-related cash payments and $0.1 million of acquisition-related payments. | • Cash burn for the three months ended December 31, 2022 includes $44.5 million of proceeds from the sale of RUO kit assets, $9.3 million of restructuring-related cash payments and $0.1 million of acquisition-related payments. | • Cash burn for the three months ended December 31, 2022 includes $44.5 million of proceeds from the sale of RUO kit assets, $9.3 million of restructuring-related cash payments and $0.1 million of acquisition-related payments. | • Cash burn for the three months ended December 31, 2022 includes $44.5 million of proceeds from the sale of RUO kit assets, $9.3 million of restructuring-related cash payments and $0.1 million of acquisition-related payments. | • Cash burn for the three months ended December 31, 2022 includes $44.5 million of proceeds from the sale of RUO kit assets, $9.3 million of restructuring-related cash payments and $0.1 million of acquisition-related payments. |

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Contacts for Invitae:

Investor Relations

Hoki Luk

ir@invitae.com

Public Relations

Amy Hadsock

pr@invitae.com

<br>