# EDGAR Filing Document

**Accession Number:** 0001299130
**File Stem:** 0001299130-26-000036
**Filing Date:** 2026-2
**Character Count:** 32564
**Document Hash:** 7744fd9e72d48284e19329995cb05edd
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001299130-26-000036.hdr.sgml**: 20260225

**ACCESSION NUMBER**: 0001299130-26-000036

**CONFORMED SUBMISSION TYPE**: S-8

**PUBLIC DOCUMENT COUNT**: 15

**REFERENCES 429**: 333-170211

**REFERENCES 429**: 333-179810

**REFERENCES 429**: 333-186065

**REFERENCES 429**: 333-193437

**REFERENCES 429**: 333-201678

**REFERENCES 429**: 333-209157

**REFERENCES 429**: 333-215746

**REFERENCES 429**: 333-222696

**REFERENCES 429**: 333-229368

**REFERENCES 429**: 333-236061

**REFERENCES 429**: 333-253669

**REFERENCES 429**: 333-263101

**REFERENCES 429**: 333-270122

**REFERENCES 429**: 333-277486

**REFERENCES 429**: 333-285848

**FILED AS OF DATE**: 20260225

**DATE AS OF CHANGE**: 20260225

**EFFECTIVENESS DATE**: 20260225

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
- **CENTRAL INDEX KEY:** 0001299130
- **STANDARD INDUSTRIAL CLASSIFICATION:** LABORATORY ANALYTICAL INSTRUMENTS [3826]
- **ORGANIZATION NAME:** 08 Industrial Applications and Services
- **EIN:** 161590339
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** S-8
- **SEC ACT:** 1933 Act
- **SEC FILE NUMBER:** 333-293737
- **FILM NUMBER:** 26678851

**BUSINESS ADDRESS:**
- **STREET 1:** 1305 O'BRIEN DRIVE
- **CITY:** MENLO PARK
- **STATE:** CA
- **ZIP:** 94025
- **BUSINESS PHONE:** 650-521-8000

**MAIL ADDRESS:**
- **STREET 1:** 1305 O'BRIEN DRIVE
- **CITY:** MENLO PARK
- **STATE:** CA
- **ZIP:** 94025

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** PACIFIC BIOSCIENCES OF CALIFORNIA INC
- **DATE OF NAME CHANGE:** 20050829

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** NANOFLUIDICS INC
- **DATE OF NAME CHANGE:** 20040729

**As filed with the Securities and Exchange Commission on February 25, 2026**

**Registration No. 333-**

**UNITED STATES**

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549** 

________________________________________________________________________________

**Form S-8**

**REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933** 

________________________________________________________________________________

**Pacific Biosciences of California, Inc.**

**(Exact name of registrant as specified in its charter)**

________________________________________________________________________________

---

| | |
|:---|:---|
| **Delaware** | **16-1590339** |
| **(State or other jurisdiction of<br>incorporation or organization)** | **(I.R.S. Employer<br>Identification No.)** |
| **1305 O'Brien Drive** <br>**Menlo Park, CA 94025** | **1305 O'Brien Drive** <br>**Menlo Park, CA 94025** |
| **(Address, including zip code, of principal executive offices)** | **(Address, including zip code, of principal executive offices)** |

---

**Pacific Biosciences of California, Inc. 2010 Employee Stock Purchase Plan**

**(Full title of the plan)**

**Christian O. Henry**

**Chief Executive Officer and President**

**1305 O'Brien Drive**

**Menlo Park, CA 94025**

**(Name and address of agent for service)**

**(650) 521-8000**

**(Telephone number, including area code, of agent for service)** 

**Copies to:**

**Andrew D. Hoffman**

**Zachary B. Myers**

**Wilson Sonsini Goodrich & Rosati, P.C.**

**650 Page Mill Road**

**Palo Alto, CA 94304**

**(650) 493-9300**

**Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer," "smaller reporting company," and "emerging growth company" in Rule 12b-2 of the Exchange Act.**

---

| | | | |
|:---|:---|:---|:---|
| Large accelerated filer | □ | Accelerated filer | ⌧ |
| Non-accelerated filer | □ | Smaller reporting company | □ |
| | | Emerging growth company | □ |

---

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. □

------

**EXPLANATORY NOTE** 

This Registration Statement on Form S-8 (the "Registration Statement") is being filed by Pacific Biosciences of California, Inc., a Delaware corporation (the "Registrant"), for the purpose of registering an additional 4,000,000 shares of common stock, par value $0.001 per share (the "Common Stock"), that were reserved for issuance under the Company's 2010 Employee Stock Purchase Plan (the "2010 ESPP"). The Registrant previously filed with the Securities and Exchange Commission (the "Commission") Registration Statements on Forms S-8 on October 29, 2010 (SEC File No. 333-170211), March 1, 2012 (SEC File No. 333-179810), January 17, 2013 (SEC File No. 333-186065), January 21, 2014 (SEC File No. 333-193437), January 23, 2015 (SEC File No. 333-201678), January 28, 2016 (SEC File No. 333-209157), January 26, 2017 (SEC File No. 333-215746), January 25, 2018 (SEC File No. 333-222696), January 25, 2019 (SEC File No. 333-229368), January 24, 2020 (SEC File No. 333-236061), March 1, 2021 (SEC File No. 333-253669), February 28, 2022 (SEC File No. 333-263101), February 28, 2023 (SEC File No. 333-270122), February 29, 2024 (SEC File No. 333-277486), and March 17, 2025 (SEC File No. 333-285848) (collectively, the "Prior Registration Statements") registering shares of Common Stock issuable under the 2010 ESPP. This Registration Statement relates to securities of the same class as those to which the Prior Registration Statements relate and is submitted in accordance with General Instruction E of Form S-8 regarding Registration of Additional Securities. Pursuant to General Instruction E of Form S-8, the contents of the Prior Registration Statements are incorporated herein by reference and made part of this Registration Statement, except for Items 3 and 8, which are being updated by this Registration Statement.

**PART I**

**INFORMATION REQUIRED IN THE PROSPECTUS**

The documents containing the information specified in Item 1 and Item 2 of this Registration Statement will be sent or given to employees, officers, directors or others as specified by Rule 428(b)(1) under the Securities Act of 1933, as amended (the "Securities Act"). In accordance with the rules and regulations of the Commission and the instructions to the Registration Statement, such documents are not being filed with the Commission either as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424.

------

**PART II**

**INFORMATION REQUIRED IN REGISTRATION STATEMENT**

**Item 3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Incorporation of Documents by Reference.**

The Registrant hereby incorporates by reference into this Registration Statement the following documents previously filed with the Commission:

(1) The Registrant's Annual Report on <u>[Form 10-K](https://www.sec.gov/ix?doc=/Archives/edgar/data/0001299130/000129913026000034/pacb-20251231.htm)</u> for its fiscal year ended December 31, 2025, filed with the Commission on February 25, 2026 (the "2025 Form 10-K") pursuant to Section 13(a) of the Securities Exchange Act of 1934, as amended (the "Exchange Act");

(2) All other reports filed with the Commission pursuant to Sections 13(a) or 15(d) of the Exchange Act since the end of the fiscal year covered by the Registrant's Annual Report referred to in (1) above (other than the portions of these documents not deemed to be filed); and

(3) The description of the Registrant's Common Stock contained in the Registrant's Registration Statement on <u>[Form 8-A](https://www.sec.gov/Archives/edgar/data/1299130/000119312510224288/d8a12b.htm)</u> (File No. 001-34899) filed with the Commission on October 6, 2010, pursuant to Section 12(b) of the Exchange Act, including any amendment or report filed for the purpose of updating such description, including Exhibit 4.2 to the 2025 Form 10-K.

All other reports or documents filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act on or after the date of this Registration Statement and prior to the filing of a post-effective amendment to this Registration Statement that indicates that all securities offered have been sold or that deregisters all securities then remaining unsold shall be deemed to be incorporated by reference in this Registration Statement and to be part hereof from the date of filing of such reports and documents; provided, however, that documents or information deemed to have been furnished and not filed in accordance with the rules of the Commission shall not be deemed incorporated by reference into this Registration Statement.

Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.

**Item 4.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Description of Securities.**

Not applicable.

**Item 5.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Interests of Named Experts and Counsel.**

Not applicable.

**Item 6.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Indemnification of Directors and Officers.**

Section 145 of the Delaware General Corporation Law authorizes a corporation's board of directors to grant, and authorizes a court to award, indemnity to officers, directors and other corporate agents.

The Registrant's certificate of incorporation contains provisions that limit the liability of its directors and certain of its officers for monetary damages to the fullest extent permitted by the Delaware General Corporation Law. Consequently, the Registrant's directors and certain of its officers will not be personally liable to the Registrant or its stockholders for monetary damages for any breach of fiduciary duty as directors or officers, except liability for the following:

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• any breach of their duty of loyalty to us or our stockholders;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• any act or omission not in good faith or that involves intentional misconduct or a knowing violation of law;

------

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• with respect to a director, unlawful payments of dividends or unlawful stock repurchases or redemptions as provided in Section 174 of the Delaware General Corporation Law;

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• any transaction from which they derived an improper personal benefit; or

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• with respect to an officer, any action by or in the right of the corporation.

Under Delaware law, these officers include the president, chief executive officer, chief operating officer, chief financial officer, chief legal officer, controller, treasurer, chief accounting officer, any officer identified in the Registrant's

public filings with the Commission as a named executive officer, and any other officer who has consented to being identified as an officer for purposes of service of process in Delaware.

Any repeal, amendment or elimination of these provisions by our stockholders or by changes in law, or the adoption of any other provision of the Registrant's certificate of incorporation inconsistent with these provisions will not adversely affect any right or protection of the Registrant's directors or officers existing at the time of such repeal, amendment, elimination or adoption of such inconsistent provision with respect to acts or omissions occurring prior to such repeal, amendment, elimination or adoption of such inconsistent provision. If the Delaware General Corporation Law is amended to authorize corporation action further eliminating or limiting the personal liability of directors or officers of corporations, then the personal liability of the Registrant's directors or officers will be eliminated or limited to the fullest extent permitted by the Delaware General Corporation Law, as so amended.

In addition, the Registrant's bylaws provide that the Registrant will indemnify its directors and officers, and may indemnify its employees, agents and any other persons, to the fullest extent permitted by the Delaware General Corporation Law. The Registrant's bylaws also provide that it must advance expenses actually and reasonably incurred by a director or officer in advance of the final disposition of any threatened, pending or completed action, suit or proceeding, subject to limited exceptions.

Further, the Registrant has entered into indemnification agreements with each of its directors and executive officers that may be broader than the specific indemnification provisions contained in the Delaware General Corporation Law and pursuant to the Registrant's bylaws. These indemnification agreements require the Registrant to, among other things, indemnify its directors and executive officers against liabilities that may arise by reason of their status or service. These indemnification agreements also generally require the Registrant to advance all expenses incurred by its directors and executive officers in investigating or defending any such action, suit or proceeding. The Registrant believes that these agreements are necessary to attract and retain qualified individuals to serve as directors and executive officers.

The limitation of liability and indemnification provisions in the Registrant's certificate of incorporation, bylaws and indemnification agreements may discourage stockholders from bringing a lawsuit against its directors and officers for breach of their fiduciary duties. They may also reduce the likelihood of derivative litigation against the Registrant's directors and officers, even though an action, if successful, might benefit the Registrant and other stockholders. Further, a stockholder's investment may be adversely affected to the extent that the Registrant pays the costs of settlement and damage awards against its directors and officers as required by these indemnification provisions.

The Registrant has obtained insurance policies under which, subject to the limitations of the policies, coverage is provided to its directors and officers against loss arising from claims made by reason of breach of fiduciary duty or other wrongful acts as a director or officer, including claims relating to public securities matters, and to the Registrant with respect to payments that may be made by the Registrant to its directors and officers pursuant to the Registrant's indemnification obligations or otherwise as a matter of law.

**Item 7.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Exemption from Registration Claimed.**

Not applicable.

------

**Item 8.&nbsp;&nbsp;&nbsp;&nbsp;Exhibits**

**Exhibit Index**

---

| | | | | |
|:---|:---|:---|:---|:---|
| | | **Incorporated by reference herein** | **Incorporated by reference herein** | **Incorporated by reference herein** |
| **Exhibit<br>Number** |<br>**Description** | **Form** | **Exhibit No.** | **Filing Date** |
| <u>[3.1](https://www.sec.gov/Archives/edgar/data/1299130/000119312511075269/dex31.htm)</u> | <u>[Amended and Restated Certificate of Incorporation of the Registrant](https://www.sec.gov/Archives/edgar/data/1299130/000119312511075269/dex31.htm)</u> | 10-K | 3.1 | March 23, 2011 |
| <u>[3.2](https://www.sec.gov/Archives/edgar/data/1299130/000129913022000128/pacb-20221103xex3_1.htm)</u> | <u>[Third Amended and Restated Bylaws of the Registrant](https://www.sec.gov/Archives/edgar/data/1299130/000129913022000128/pacb-20221103xex3_1.htm)</u> | 8-K | 3.1 | November 7, 2022 |
| <u>[3.3](https://www.sec.gov/Archives/edgar/data/1299130/000129913024000146/exhibit31-certificateofame.htm)</u> | <u>[Certificate of Amendment to the Amended and Restated Certificate of Incorporation of Pacific Biosciences of California, Inc. to declassify the Board](https://www.sec.gov/Archives/edgar/data/1299130/000129913024000146/exhibit31-certificateofame.htm)</u> | 8-K | 3.1 | June 20, 2024 |
| <u>[3.4](https://www.sec.gov/Archives/edgar/data/1299130/000129913024000146/exhibit32-certificateofame.htm)</u> | <u>[Certificate of Amendment to the Certificate of Incorporation of Pacific Biosciences of California, Inc. to limit the liability of officers](https://www.sec.gov/Archives/edgar/data/1299130/000129913024000146/exhibit32-certificateofame.htm)</u> | 8-K | 3.2 | June 20, 2024 |
| <u>[4.1](https://www.sec.gov/Archives/edgar/data/1299130/000119312510221497/dex41.htm)</u> | <u>[Specimen Common Stock Certificate](https://www.sec.gov/Archives/edgar/data/1299130/000119312510221497/dex41.htm)</u> | S-1/A | 4.1 | October 1, 2010 |
| <u>[4.2](https://www.sec.gov/Archives/edgar/data/1299130/000129913026000034/pacb-exx42xdescriptionofse.htm)</u> | <u>[Description of Registrant's securities registered under Section 12 of the Exchange Act](https://www.sec.gov/Archives/edgar/data/1299130/000129913026000034/pacb-exx42xdescriptionofse.htm)</u> | 10-K | 4.2 | February 25, 2026 |
| <u>[4.3+](https://www.sec.gov/Archives/edgar/data/1299130/000119312510189512/dex105.htm)</u> | <u>[2010 Employee Stock Purchase Plan and forms of agreement thereunder](https://www.sec.gov/Archives/edgar/data/1299130/000119312510189512/dex105.htm)</u> | S-1 | 10.5 | August 16, 2010 |
| <u>[5.1\*](pacb-20260225xex51xformsx8.htm)</u> | <u>[Opinion of Wilson Sonsini Goodrich & Rosati, Professional Corporation](pacb-20260225xex51xformsx8.htm)</u>  |  |  |  |
| <u>[23.1\*](pacb-20260225xex231xformsx8.htm)</u> | <u>[Consent of Independent Registered Public Accounting Firm](pacb-20260225xex231xformsx8.htm)</u> |  |  |  |
| <u>[23.2\*](pacb-20260225xex51xformsx8.htm)</u> | <u>[Consent of Wilson Sonsini Goodrich & Rosati, Professional Corporation (contained in Exhibit 5.1 hereto)](pacb-20260225xex51xformsx8.htm)</u> |  |  |  |
| <u>[24.1\*](#i06392e52da5a46a19ee2442f5f88e4d1_1291)</u> | <u>[Power of Attorney (contained on signature page hereto)](#i06392e52da5a46a19ee2442f5f88e4d1_1291)</u> |  |  |  |
| <u>[107\*](exfilingfees.htm)</u> | <u>[Filing Fee Table](exfilingfees.htm)</u> |  |  |  |

---

_____________________

---

| | |
|:---|:---|
| + | Indicates management contract or compensatory plan, contract or arrangement. |
| \* | Filed herewith. |

---

------

**Item 9.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Undertakings.**

A. The undersigned registrant hereby undertakes:

(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:

(i) To include any prospectus required by Section 10(a)(3) of the Securities Act of 1933;

(ii) To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set forth in the "Calculation of Registration Fee" table in the effective registration statement;

(iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement;

*Provided, however,* that paragraphs (A)(1)(i) and (A)(1)(ii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the registrant pursuant to Section 13 or Section 15(d) of the Exchange Act of 1934 that are incorporated by reference in the registration statement.

(2) That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial *bona fide* offering thereof.

(3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

B. The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act of 1933, each filing of the registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial *bona fide* offering thereof.

C. Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Act and will be governed by the final adjudication of such issue.

------

**Signatures** 

Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Menlo Park, State of California, on February 25, 2026.

---

| | |
|:---|:---|
| **PACIFIC BIOSCIENCES OF CALIFORNIA, INC.** | **PACIFIC BIOSCIENCES OF CALIFORNIA, INC.** |
| By: | /s/ Michele Farmer |
|  | **Michele Farmer** |
|  | **Vice President and Chief Accounting Officer** |

---

**POWER OF ATTORNEY**

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Christian O. Henry, Jim R. Gibson, Brett Atkins and Michele Farmer, and each of them, as his or her true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for each individual in any and all capacities, to sign any and all amendments to this Registration Statement on Form S-8 of Pacific Biosciences of California, Inc., and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or the individual's substitute, may lawfully do or cause to be done by virtue hereof.

------

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, this report has been signed by the following persons on behalf of the Registrant in the capacities and on the dates indicated.

---

| | | |
|:---|:---|:---|
| **Signature** | **Title** | **Date** |
| <u>/s/ Christian O. Henry</u> | Director, President, Chief Executive Officer<br>(Principal Executive Officer) | February 25, 2026 |
| Christian O. Henry | Director, President, Chief Executive Officer<br>(Principal Executive Officer) | February 25, 2026 |
| <u>/s/ Jim R. Gibson</u> | Chief Financial Officer<br>(Principal Financial Officer) | February 25, 2026 |
| Jim R. Gibson | Chief Financial Officer<br>(Principal Financial Officer) | February 25, 2026 |
| <u>/s/ Michele Farmer</u> | Vice President and Chief Accounting Officer (Principal Accounting Officer) | February 25, 2026 |
| Michele Farmer | Vice President and Chief Accounting Officer (Principal Accounting Officer) | February 25, 2026 |
| <u>/s/ John F. Milligan</u> | Chairman of the Board of Directors | February 25, 2026 |
| John F. Milligan |  |  |
| <u>/s/ William W. Ericson</u> | Director | February 25, 2026 |
| William W. Ericson |  |  |
| <u>/s/ Randall S. Livingston</u> | Director | February 25, 2026 |
| Randall S. Livingston |  |  |
| <u>/s/ Marshall L. Mohr</u> | Director | February 25, 2026 |
| Marshall L. Mohr |  |  |
| <u>/s/ Kathy Ordoñez</u> | Director | February 25, 2026 |
| Kathy Ordoñez |  |  |
| <u>/s/ Lucy Shapiro</u> | Director | February 25, 2026 |
| Lucy Shapiro |  |  |
| <u>/s/ Christopher M. Smith</u> | Director | February 25, 2026 |
| Christopher M. Smith |  |  |
| <u>/s/ Hannah A. Valantine</u> | Director | February 25, 2026 |
| Hannah A. Valantine |  |  |

---

## Ex-Filing

?xml version='1.0' encoding='ASCII'? exfilingfees

**EXHIBIT 107**

**Calculation of Filing Fee Table** 

**Form S-8**

(Form Type)

**Pacific Biosciences of California, Inc.**

(Exact Name of Registrant as Specified in its Charter)

<u>Table 1: Newly Registered Securities</u>

---

| | | | | | | | |
|:---|:---|:---|:---|:---|:---|:---|:---|
| **Security Type** | **Security Class Title**<sup>(1)</sup> | **Fee Calculation Rule** | **Amount Registered**<sup>(2)</sup> | **Proposed Maximum Offering Price Per Share**<sup>(3)</sup> | **Proposed<br>Maximum Aggregate Offering Price** | **Fee Rate** | **Amount of Registration Fee** |
| Equity | Common Stock, $0.001 par value per share, reserved for issuance pursuant to the 2010 Employee Stock Purchase Plan | 457(c) and 457(h) | 4000000 | $1.36 | $5440000 | $0.0001381 | $751.27 |
| **Total Offering Amounts** |  |  |  |  | $5440000 |  | $751.27 |
| **Total Fee Offsets** | **Total Fee Offsets** | **Total Fee Offsets** | **Total Fee Offsets** | **Total Fee Offsets** | **Total Fee Offsets** | **Total Fee Offsets** | $— |
| **Net Fee Due** | **Net Fee Due** | **Net Fee Due** | **Net Fee Due** | **Net Fee Due** | **Net Fee Due** | **Net Fee Due** | $751.27 |

---

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(1)&nbsp;&nbsp;&nbsp;&nbsp;Represents shares of common stock, par value $0.001 per share ("Common Stock") of Pacific Biosciences of California, Inc. (the "Registrant") available for issuance pursuant to awards granted pursuant to the Registrant's 2010 Employee Stock Purchase Plan (the "2010 ESPP"). In addition, pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement shall also cover any additional shares of the Registrant's Common Stock that become issuable under the 2010 ESPP by reason of an event such as any stock split, stock dividend, recapitalization or similar transaction effected without receipt of consideration that increases the number of the Registrant's outstanding shares of Common Stock.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(2)&nbsp;&nbsp;&nbsp;&nbsp;Represents 4,000,000 additional shares of Common Stock available for issuance as a result of the annual evergreen increase pursuant to the 2010 ESPP.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(3)&nbsp;&nbsp;&nbsp;&nbsp;Estimated in accordance with Rules (c) and (h) of Rule 457 under the Securities Act solely for the purposes of calculating the registration fee on the basis of 85% of $1.60 per share, which represents the average of the high and low price per share of the Registrant's Common Stock on February 23, 2026, as reported on The Nasdaq Global Select Market. Pursuant to the 2010 ESPP, the purchase price of the shares of the Registrant's Common Stock reserved for issuance thereunder will be 85% of the lower of the fair market value of the Common Stock on the first trading day of the offering period or on the last day of the offering period.

## Exhibit 5.1

**Exhibit 5.1**

---

| | |
|:---|:---|
| ![image_11a.jpg](image_11a.jpg) | &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Wilson Sonsini Goodrich & Rosati<br>Professional Corporation<br>650 Page Mill Road<br>Palo Alto, California 94304-1050<br>o: 650.493.9300<br>f: 650.493.6811 |

---

February 25, 2026

Pacific Biosciences of California, Inc.<br>1305 O'Brien Drive<br>Menlo Park, CA 94025

**Re:&nbsp;&nbsp;&nbsp;&nbsp;Registration Statement on Form S-8**

Ladies and Gentlemen:

At your request, we have examined the Registration Statement on Form S-8 (the "Registration Statement") to be filed by Pacific Biosciences of California, Inc., a Delaware corporation (the "Company"), with the Securities and Exchange Commission (the "Commission"), on or about the date hereof, relating to the registration under the Securities Act of 1933, as amended (the "Act"), of 4,000,000 shares of your common stock, par value $0.001 per share (the "Shares"), to be issued under the Company's 2010 Employee Stock Purchase Plan (the "2010 ESPP"). As your legal counsel, we have reviewed the actions proposed to be taken by you in connection with the issuance and sale of the Shares to be issued under the 2010 ESPP.

On the basis of the foregoing, and in reliance thereon, we are of the opinion that the Shares, when issued and sold in the manner described in the 2010 ESPP and pursuant to the agreements that accompany the 2010 ESPP, will be legally and validly issued, fully paid and nonassessable.

We hereby consent to the filing of this opinion as an exhibit to the above-referenced Registration Statement and to the use of our name wherever it appears in the Registration Statement and in any amendments thereto. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Act or the rules and regulations of the Commission thereunder.

Very truly yours,

/s/ Wilson Sonsini Goodrich & Rosati, P.C.

WILSON SONSINI GOODRICH & ROSATI

Professional Corporation

AUSTIN BOSTON BOULDER BRUSSELS HONG KONG LONDON LOS ANGELES NEW YORK PALO ALTO<br>SALT LAKE CITY SAN DIEGO SAN FRANCISCO SEATTLE SHANGHAI WASHINGTON, DC WILMINGTON, DE

## Exhibit 23.1

**Exhibit 23.1** 

**Consent of Independent Registered Public Accounting Firm**

We consent to the incorporation by reference in the Registration Statement (Form S-8) pertaining to the Pacific Biosciences of California, Inc. 2010 Employee Stock Purchase Plan of our reports dated February 25, 2026, with respect to the consolidated financial statements of Pacific Biosciences of California, Inc., and the effectiveness of internal control over financial reporting of Pacific Biosciences of California, Inc. included in its Annual Report (Form 10-K) for the year ended December 31, 2025, filed with the Securities and Exchange Commission.

/s/ Ernst & Young LLP

San Mateo, California

February 25, 2026

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