# EDGAR Filing Document

**Accession Number:** 0001816307
**File Stem:** 0001420506-23-000635
**Filing Date:** 2023-2
**Character Count:** 13219
**Document Hash:** f200f7d4738c5264234da5102cccb6ad
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001420506-23-000635.hdr.sgml**: 20230214

**ACCESSION NUMBER**: 0001420506-23-000635

**CONFORMED SUBMISSION TYPE**: 13F-HR

**PUBLIC DOCUMENT COUNT**: 2

**CONFORMED PERIOD OF REPORT**: 20221231

**FILED AS OF DATE**: 20230214

**DATE AS OF CHANGE**: 20230214

**EFFECTIVENESS DATE**: 20230214

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** SILVERARC CAPITAL MANAGEMENT, LLC
- **CENTRAL INDEX KEY:** 0001816307
- **IRS NUMBER:** 834542901
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 13F-HR
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 028-21010
- **FILM NUMBER:** 23625588

**BUSINESS ADDRESS:**
- **STREET 1:** 20 PARK PLAZA
- **STREET 2:** 4TH FLOOR
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02116
- **BUSINESS PHONE:** 617.284.6952

**MAIL ADDRESS:**
- **STREET 1:** 20 PARK PLAZA
- **STREET 2:** 4TH FLOOR
- **CITY:** BOSTON
- **STATE:** MA
- **ZIP:** 02116

### FORM 13F COVER PAGE

**Report for the Calendar Year or Quarter Ended:** 12-31-2022

**Check here if Amendment** [ ] **Amendment Number:** 

**This Amendment (Check only one.):** [ ] is a restatement.

[ ] adds new holdings entries.

**Institutional Investment Manager Filing this Report:**

**Name:** SILVERARC CAPITAL MANAGEMENT LLC<br>**Address:** 20 PARK PLAZA<br>4TH FLOOR<br>BOSTON, MA 02116

**Form 13F File Number:** 028-21010

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

**Person Signing this Report on Behalf of Reporting Manager:**

**Name:** ANDREW TIMPSON<br>**Title:** CHIEF COMPLIANCE OFFICER<br>**Phone:** 617.284.6952

**Signature, Place, and Date of Signing:**

ANDREW TIMPSON CHIEF COMPLIANCE OFFICER  BOSTON, MA  02-14-2023<br>[Signature]  [City, State]  [Date]

**Report Type (Check only one.):**

[x] **13F HOLDINGS REPORT.** (Check here if all holdings of this reporting manager are reported in this report.)

[ ] **13F NOTICE.** (Check here if no holdings are reported in this report, and all holdings are reported by other reporting manager(s).)

[ ] **13F COMBINATION REPORT.** (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

### Form 13F Summary Page

**Report Summary:**

**Number of Other Included Managers:** 1

**Form 13F Information Table Entry Total:** 90

**Form 13F Information Table Value Total:** $349550312

      (round to nearest dollar)

**List of Other Included Managers:**

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.

[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]

| No.   | Name                  | Form 13F File Number   |
|:---|:---|:---|
|  | SILVERARC CAPITAL LLC | 028-20993              |

### FORM 13F INFORMATION TABLE

---

|  |  |  |  |  |  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | VOTING AUTHORITY | VOTING AUTHORITY | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | VALUE (x$1000) | SHRS OR PRN AMT | SH/PRN | PUT/CALL | INVESTMENT DISCRETION | OTHER MANAGER | SOLE | SHARED | NONE |
| Aclaris Therapeutics Inc | EQUITIES | 00461U105 |  | 5547040 | 352193 | SH |  | SOLE |  | 352193 | 0 | 0 |
| Acumen Pharmaceuticals Inc | EQUITIES | 00509G209 |  | 1593621 | 295115 | SH |  | SOLE |  | 295115 | 0 | 0 |
| Aerovate Therapeutics Inc | EQUITIES | 008064107 |  | 1081346 | 36906 | SH |  | SOLE |  | 36906 | 0 | 0 |
| Akero Therapeutics Inc | LONG OPTION PUTS | 00973Y108 |  | 8220000 | 150000 | SH | Put | SOLE |  | 150000 | 0 | 0 |
| Akero Therapeutics Inc | LONG OPTION CALLS | 00973Y108 |  | 8220000 | 150000 | SH | Call | SOLE |  | 150000 | 0 | 0 |
| Akero Therapeutics Inc | EQUITIES | 00973Y108 |  | 9431080 | 172100 | SH |  | SOLE |  | 172100 | 0 | 0 |
| Allakos Inc | EQUITIES | 01671P100 |  | 4047502 | 480701 | SH |  | SOLE |  | 480701 | 0 | 0 |
| Alnylam Pharmaceuticals Inc | EQUITIES | 02043Q107 |  | 8947998 | 37652 | SH |  | SOLE |  | 37652 | 0 | 0 |
| Altimmune Inc | EQUITIES | 02155H200 |  | 831482 | 50546 | SH |  | SOLE |  | 50546 | 0 | 0 |
| Altimmune Inc. | LONG OPTION CALLS | 02155H200 |  | 2632000 | 160000 | SH | Call | SOLE |  | 160000 | 0 | 0 |
| Amryt Pharma PLC | EQUITIES | 03217L106 |  | 1408864 | 192995 | SH |  | SOLE |  | 192995 | 0 | 0 |
| Anavex Life Science Corp | LONG OPTION PUTS | 032797300 |  | 9331302 | 1007700 | SH | Put | SOLE |  | 1007700 | 0 | 0 |
| Anavex Life Science Corp | LONG OPTION CALLS | 032797300 |  | 950076 | 102600 | SH | Call | SOLE |  | 102600 | 0 | 0 |
| Ascendis Pharma A/S | EQUITIES | 04351P101 |  | 2827432 | 23151 | SH |  | SOLE |  | 23151 | 0 | 0 |
| Astria Therapeutics Inc | EQUITIES | 04635X102 |  | 1209128 | 81204 | SH |  | SOLE |  | 81204 | 0 | 0 |
| Avidity Biosciences Inc | EQUITIES | 05370A108 |  | 2840320 | 128000 | SH |  | SOLE |  | 128000 | 0 | 0 |
| Axsome Therapeutics Inc | EQUITIES | 05464T104 |  | 771300 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| Bellus Health Inc | EQUITIES | 07987C204 |  | 14034581 | 1707370 | SH |  | SOLE |  | 1707370 | 0 | 0 |
| BioCryst Pharmaceuticals Inc | EQUITIES | 09058V103 |  | 3124546 | 272173 | SH |  | SOLE |  | 272173 | 0 | 0 |
| Bioatla Inc | EQUITIES | 09077B104 |  | 4511719 | 546875 | SH |  | SOLE |  | 546875 | 0 | 0 |
| Biogen Idec Inc | EQUITIES | 09062X103 |  | 6085317 | 21975 | SH |  | SOLE |  | 21975 | 0 | 0 |
| Braze Inc | EQUITIES | 10576N102 |  | 272800 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| CTI BioPharma Corp | EQUITIES | 12648L601 |  | 1528710 | 254361 | SH |  | SOLE |  | 254361 | 0 | 0 |
| Celldex Therapeutics Inc | EQUITIES | 15117B202 |  | 2437934 | 54699 | SH |  | SOLE |  | 54699 | 0 | 0 |
| Cerus Corp | EQUITIES | 157085101 |  | 5964151 | 1634014 | SH |  | SOLE |  | 1634014 | 0 | 0 |
| Cincor Pharma Inc | EQUITIES | 17240Y109 |  | 4859245 | 395382 | SH |  | SOLE |  | 395382 | 0 | 0 |
| Codexis Inc | EQUITIES | 192005106 |  | 674474 | 144737 | SH |  | SOLE |  | 144737 | 0 | 0 |
| Cogent Biosciences Inc | EQUITIES | 19240Q201 |  | 2069240 | 179000 | SH |  | SOLE |  | 179000 | 0 | 0 |
| Compass Therapeutics Inc. | EQUITIES | 20454B104 |  | 1349584 | 268307 | SH |  | SOLE |  | 268307 | 0 | 0 |
| Compugen Ltd | EQUITIES | M25722105 |  | 477689 | 667443 | SH |  | SOLE |  | 667443 | 0 | 0 |
| Crinetics Pharmaceuticals Inc | EQUITIES | 22663K107 |  | 2795270 | 152747 | SH |  | SOLE |  | 152747 | 0 | 0 |
| Cue Biopharma Inc | EQUITIES | 22978P106 |  | 872892 | 306278 | SH |  | SOLE |  | 306278 | 0 | 0 |
| Cullinan Oncology Inc | EQUITIES | 230031106 |  | 2420339 | 229416 | SH |  | SOLE |  | 229416 | 0 | 0 |
| Cvrx Inc | EQUITIES | 126638105 |  | 5772616 | 314584 | SH |  | SOLE |  | 314584 | 0 | 0 |
| Cytokinetics Inc | EQUITIES | 23282W605 |  | 801850 | 17500 | SH |  | SOLE |  | 17500 | 0 | 0 |
| Design Therapeutics Inc | EQUITIES | 25056L103 |  | 585077 | 57025 | SH |  | SOLE |  | 57025 | 0 | 0 |
| Eliem Therapeutics Inc | EQUITIES | 28658R106 |  | 1501771 | 409202 | SH |  | SOLE |  | 409202 | 0 | 0 |
| Eloxx Pharmaceuticals Inc | EQUITIES | 29014R202 |  | 48914 | 26876 | SH |  | SOLE |  | 26876 | 0 | 0 |
| Evogene Ltd | EQUITIES | M4119S104 |  | 105253 | 150361 | SH |  | SOLE |  | 150361 | 0 | 0 |
| Fresh Tracks Therapeutics Inc | EQUITIES | 10802T204 |  | 15000 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| Gilead Sciences Inc | EQUITIES | 375558103 |  | 4460938 | 51962 | SH |  | SOLE |  | 51962 | 0 | 0 |
| GlaxoSmithKline PLC | EQUITIES | 37733W204 |  | 4785295 | 136178 | SH |  | SOLE |  | 136178 | 0 | 0 |
| Gossamer Bio Inc | EQUITIES | 38341P102 |  | 217000 | 100000 | SH |  | SOLE |  | 100000 | 0 | 0 |
| Horizon Therapeutics Plc | EQUITIES | G46188101 |  | 2623545 | 23054 | SH |  | SOLE |  | 23054 | 0 | 0 |
| IVERIC bio Inc | EQUITIES | 46583P102 |  | 1889283 | 88243 | SH |  | SOLE |  | 88243 | 0 | 0 |
| Immatics Nv | EQUITIES | N44445109 |  | 3830553 | 439788 | SH |  | SOLE |  | 439788 | 0 | 0 |
| Immunic Inc | EQUITIES | 4525EP101 |  | 490918 | 350656 | SH |  | SOLE |  | 350656 | 0 | 0 |
| ImmunoGen Inc | EQUITIES | 45253H101 |  | 2020054 | 407269 | SH |  | SOLE |  | 407269 | 0 | 0 |
| ImmunoGen Inc. | LONG OPTION CALLS | 45253H101 |  | 1150720 | 232000 | SH | Call | SOLE |  | 232000 | 0 | 0 |
| Immunovant Inc | EQUITIES | 45258J102 |  | 9223149 | 519614 | SH |  | SOLE |  | 519614 | 0 | 0 |
| Insmed Inc | EQUITIES | 457669307 |  | 2486811 | 124465 | SH |  | SOLE |  | 124465 | 0 | 0 |
| Intellia Therapeutics Inc | EQUITIES | 45826J105 |  | 1143345 | 32770 | SH |  | SOLE |  | 32770 | 0 | 0 |
| Intra-Cellular Therapies Inc | EQUITIES | 46116X101 |  | 7428169 | 140366 | SH |  | SOLE |  | 140366 | 0 | 0 |
| Krystal Biotech Inc | EQUITIES | 501147102 |  | 4637143 | 58535 | SH |  | SOLE |  | 58535 | 0 | 0 |
| LAVA Therapeutics NV | EQUITIES | N51517105 |  | 1532167 | 437762 | SH |  | SOLE |  | 437762 | 0 | 0 |
| MacroGenics Inc | EQUITIES | 556099109 |  | 4109707 | 612475 | SH |  | SOLE |  | 612475 | 0 | 0 |
| Madrigal Parmaceuticals Inc. | LONG OPTION PUTS | 558868105 |  | 8707500 | 30000 | SH | Put | SOLE |  | 30000 | 0 | 0 |
| Madrigal Pharmaceuticals Inc | EQUITIES | 558868105 |  | 14482895 | 49898 | SH |  | SOLE |  | 49898 | 0 | 0 |
| Medicus Sciences Acquisition Corp | WARRANTS | G5960S124 |  | 4499 | 49990 | SH |  | SOLE |  | 49990 | 0 | 0 |
| Meiragtx Holdings Plc | EQUITIES | G59665102 |  | 369501 | 56672 | SH |  | SOLE |  | 56672 | 0 | 0 |
| Mersana Therapeutics Inc | EQUITIES | 59045L106 |  | 6681467 | 1140182 | SH |  | SOLE |  | 1140182 | 0 | 0 |
| Merus NV | EQUITIES | N5749R100 |  | 4249671 | 274704 | SH |  | SOLE |  | 274704 | 0 | 0 |
| Morphic Holding Inc | EQUITIES | 61775R105 |  | 8948811 | 334535 | SH |  | SOLE |  | 334535 | 0 | 0 |
| Nuvalent Inc | EQUITIES | 670703107 |  | 9022238 | 302963 | SH |  | SOLE |  | 302963 | 0 | 0 |
| Oric Pharmaceuticals Inc | EQUITIES | 68622P109 |  | 7281783 | 1236296 | SH |  | SOLE |  | 1236296 | 0 | 0 |
| Pharvaris NV | EQUITIES | N69605108 |  | 1125000 | 100000 | SH |  | SOLE |  | 100000 | 0 | 0 |
| Phreesia Inc | EQUITIES | 71944F106 |  | 2763220 | 85390 | SH |  | SOLE |  | 85390 | 0 | 0 |
| Pliant Therapeutics Inc | EQUITIES | 729139105 |  | 4204333 | 217503 | SH |  | SOLE |  | 217503 | 0 | 0 |
| Point Biopharma Global Inc | EQUITIES | 730541109 |  | 2921919 | 400812 | SH |  | SOLE |  | 400812 | 0 | 0 |
| Poseida Therapeutics Inc | EQUITIES | 73730P108 |  | 11819000 | 2230000 | SH |  | SOLE |  | 2230000 | 0 | 0 |
| Praxis Precision Medicines Inc | EQUITIES | 74006W108 |  | 234213 | 98409 | SH |  | SOLE |  | 98409 | 0 | 0 |
| Prometheus Bioscience Inc. | LONG OPTION PUTS | 74349U108 |  | 18964000 | 172400 | SH | Put | SOLE |  | 172400 | 0 | 0 |
| Prometheus Biosciences Inc | EQUITIES | 74349U108 |  | 5500000 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| Prothena Corporation PLC | EQUITIES | G72800108 |  | 4320287 | 71706 | SH |  | SOLE |  | 71706 | 0 | 0 |
| Schrodinger Inc | EQUITIES | 80810D103 |  | 2018520 | 108000 | SH |  | SOLE |  | 108000 | 0 | 0 |
| Seagen Inc | EQUITIES | 81181C104 |  | 1415666 | 11016 | SH |  | SOLE |  | 11016 | 0 | 0 |
| Seres Therapeutics Inc | EQUITIES | 81750R102 |  | 2096763 | 374422 | SH |  | SOLE |  | 374422 | 0 | 0 |
| Stereotaxis Inc | EQUITIES | 85916J409 |  | 734695 | 354925 | SH |  | SOLE |  | 354925 | 0 | 0 |
| Terns Pharmaceuticals Inc | EQUITIES | 880881107 |  | 7126000 | 700000 | SH |  | SOLE |  | 700000 | 0 | 0 |
| Trevi Therapeutics Inc | EQUITIES | 89532M101 |  | 1481528 | 767631 | SH |  | SOLE |  | 767631 | 0 | 0 |
| Uniqure NV | EQUITIES | N90064101 |  | 226700 | 10000 | SH |  | SOLE |  | 10000 | 0 | 0 |
| United Therapeutics Corp | EQUITIES | 91307C102 |  | 4462788 | 16048 | SH |  | SOLE |  | 16048 | 0 | 0 |
| Vaxcyte Inc | EQUITIES | 92243G108 |  | 3986323 | 83135 | SH |  | SOLE |  | 83135 | 0 | 0 |
| Veracyte Inc | EQUITIES | 92337F107 |  | 4746000 | 200000 | SH |  | SOLE |  | 200000 | 0 | 0 |
| Vertex Pharmaceuticals Inc | EQUITIES | 92532F100 |  | 3287472 | 11384 | SH |  | SOLE |  | 11384 | 0 | 0 |
| Veru Inc. | LONG OPTION PUTS | 92536C103 |  | 924000 | 175000 | SH | Put | SOLE |  | 175000 | 0 | 0 |
| Viewray Inc | EQUITIES | 92672L107 |  | 10776013 | 2405360 | SH |  | SOLE |  | 2405360 | 0 | 0 |
| Viridian Therapeutics Inc | EQUITIES | 92790C104 |  | 87630 | 3000 | SH |  | SOLE |  | 3000 | 0 | 0 |
| WAVE Life Sciences Ltd | EQUITIES | Y95308105 |  | 350000 | 50000 | SH |  | SOLE |  | 50000 | 0 | 0 |
| Xenon Pharmaceuticals Inc | EQUITIES | 98420N105 |  | 10001617 | 253655 | SH |  | SOLE |  | 253655 | 0 | 0 |

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