# EDGAR Filing Document

**Accession Number:** 0001822791
**File Stem:** 0001437749-25-028735
**Filing Date:** 2025-9
**Character Count:** 2100
**Document Hash:** 10e439e69581bf887035a3c85c6aa205
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001437749-25-028735.hdr.sgml**: 20251209

**ACCESSION NUMBER**: 0001437749-25-028735

**CONFORMED SUBMISSION TYPE**: CORRESP

**PUBLIC DOCUMENT COUNT**: 1

**FILED AS OF DATE**: 20250910

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Clene Inc.
- **CENTRAL INDEX KEY:** 0001822791
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 852828339
- **STATE OF INCORPORATION:** DE
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** CORRESP

**BUSINESS ADDRESS:**
- **STREET 1:** 6550 SOUTH MILLROCK DRIVE, SUITE G50
- **CITY:** SALT LAKE CITY
- **STATE:** UT
- **ZIP:** 84121
- **BUSINESS PHONE:** 801-676-9695

**MAIL ADDRESS:**
- **STREET 1:** 6550 SOUTH MILLROCK DRIVE, SUITE G50
- **CITY:** SALT LAKE CITY
- **STATE:** UT
- **ZIP:** 84121

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Chelsea Worldwide Inc.
- **DATE OF NAME CHANGE:** 20200827

**Clene Inc.**

**6550 South Millrock Drive, Suite G50**

**Salt Lake City, Utah 84121**

**<u>VIA EDGAR</u>**

September 10, 2025

U.S. Securities and Exchange Commission

Division of Corporation Finance

Office of Life Sciences

100 F Street, N.E.

Washington, D.C. 20549

Attention: Chris Edwards

***Re: Clene Inc.***

***Acceleration Request for Registration Statement on Form S-3***

***File No. 333-290075***

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended (the "Act"), Clene Inc. (the "Company") hereby requests acceleration of the effective date of the above referenced registration statement (the "Registration Statement") to 4:00 p.m., Eastern Time, on September 12, 2025, or as soon thereafter as practicable.

Please contact Tom McAleavey of Holland & Knight, special counsel to the Company, by email at tom.mcaleavey@hklaw.com or by phone at (407) 244-5108 if you have any other questions or concerns regarding this matter.

*[Signature Page Follows]*

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Sincerely,

/s/ Robert Etherington

Name: Robert Etherington

Title: President and Chief Executive Officer