# EDGAR Filing Document

**Accession Number:** 0001828185
**File Stem:** 0001828185-26-000018
**Filing Date:** 2026-4
**Character Count:** 29451
**Document Hash:** b350d3b687723514f5e36f37eb3205b9
**Contains OCR:** False
**Source Format:** 

## Filing Content

## Filing Summary
**0001828185-26-000018.hdr.sgml**: 20260430

**ACCESSION NUMBER**: 0001828185-26-000018

**CONFORMED SUBMISSION TYPE**: 8-K

**PUBLIC DOCUMENT COUNT**: 14

**CONFORMED PERIOD OF REPORT**: 20260430

**ITEM INFORMATION**: Results of Operations and Financial Condition

**ITEM INFORMATION**: Financial Statements and Exhibits

**FILED AS OF DATE**: 20260430

**DATE AS OF CHANGE**: 20260430

**FILER**: 

**COMPANY DATA:**
- **COMPANY CONFORMED NAME:** Barinthus Biotherapeutics plc.
- **CENTRAL INDEX KEY:** 0001828185
- **STANDARD INDUSTRIAL CLASSIFICATION:** PHARMACEUTICAL PREPARATIONS [2834]
- **ORGANIZATION NAME:** 03 Life Sciences
- **EIN:** 000000000
- **STATE OF INCORPORATION:** X0
- **FISCAL YEAR END:** 1231

**FILING VALUES:**
- **FORM TYPE:** 8-K
- **SEC ACT:** 1934 Act
- **SEC FILE NUMBER:** 001-40367
- **FILM NUMBER:** 26920101

**BUSINESS ADDRESS:**
- **STREET 1:** 20400 CENTURY BLVD
- **STREET 2:** SUITE 210
- **CITY:** GERMANTOWN
- **STATE:** MD
- **ZIP:** 20874
- **BUSINESS PHONE:** 44 (0) 1865 818808

**MAIL ADDRESS:**
- **STREET 1:** 20400 CENTURY BLVD
- **STREET 2:** SUITE 210
- **CITY:** GERMANTOWN
- **STATE:** MD
- **ZIP:** 20874

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Vaccitech plc
- **DATE OF NAME CHANGE:** 20210407

**FORMER COMPANY:**
- **FORMER CONFORMED NAME:** Vaccitech Ltd
- **DATE OF NAME CHANGE:** 20201014

?xml version='1.0' encoding='ASCII'? brns-20260430

**UNITED STATES** 

**SECURITIES AND EXCHANGE COMMISSION**

**Washington, D.C. 20549** 

**FORM 8-K**

**CURRENT REPORT** 

**Pursuant to Section 13 or 15(d)** 

**of the Securities Exchange Act of 1934**

**Date of Report (Date of earliest event reported): April 30, 2026**

**BARINTHUS BIOTHERAPEUTICS PLC**

**(Exact name of registrant as specified in its charter)** 

---

| | | |
|:---|:---|:---|
| **England and Wales** | **001-40367** | **Not Applicable** |
| **(State or other jurisdiction<br>of incorporation)** | **(Commission<br>File Number)** | **(I.R.S. Employer<br>Identification No.)** |

---

**Barinthus Biotherapeutics plc**

**20400 Century Blvd, Suite 210,** 

**Germantown, MD 20874**

**(Address of principal executive offices, including zip code)**

**443 917-0966**

**(Registrant's telephone number, including area code)** 

**Not Applicable**

**(Former name or former address, if changed since last report)** 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☒ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

□ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

□ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

□ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

---

| | | |
|:---|:---|:---|
| <u>Title of each class</u> | <u>Trade Symbol(s)</u> | <u>Name of each exchange on which</u><br><u>registered</u> |
| American Depositary Shares | BRNS | The Nasdaq Global Market |
| Ordinary shares, nominal value £0.000025 per share\* |  |  |

---

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging growth company ⌧

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. □

\*American Depositary Shares may be evidenced by American Depositary Receipts. Each American Depositary Share represents one (1) ordinary share. Not for trading, but only in connection with the listing of the American Depositary Shares on The Nasdaq Global Market. The American Depositary Shares represent the right to receive ordinary shares and are being registered under the Securities Act of 1933, as amended, pursuant to a separate Registration Statement on Form F-6. Accordingly, the American Depositary Shares are exempt from the operation of Section 12(a) of the Securities Exchange Act of 1934, as amended, pursuant to Rule 12a-8.

**Item 2.02. Results of Operations and Financial Condition.**

On April 30, 2026, Barinthus Biotherapeutics plc (the "Company") provided an overview of the Company's progress and announced its financial results for the quarter ended March 31, 2026. The full text of the press release issued in connection with the update is furnished as Exhibit 99.1 to this Current Report on Form 8-K.

The information in Item 2.02 of this Form 8-K (including Exhibit 99.1) shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended (the "Securities Act"), or the Exchange Act, except as expressly set forth by specific reference in such a filing.

**Additional Information and Where to Find It**

In connection with the proposed transaction, the combined company has filed with the Securities and Exchange Commission (the "SEC") and mailed or otherwise provided to Company's investors and security holders a registration statement on Form S-4 that contains a joint proxy statement/prospectus (the "Registration Statement"). THE COMPANY'S INVESTORS AND SECURITY HOLDERS ARE URGED TO CAREFULLY READ THE REGISTRATION STATEMENT IN ITS ENTIRETY AND ANY OTHER DOCUMENTS FILED OR THAT WILL BE FILED BY THE COMPANY WITH THE SEC IN CONNECTION WITH THE PROPOSED TRANSACTION OR INCORPORATED BY REFERENCE THEREIN BECAUSE THEY CONTAIN OR WILL CONTAIN IMPORTANT INFORMATION ABOUT THE PROPOSED TRANSACTION AND THE PARTIES TO THE PROPOSED TRANSACTION.

Investors and security holders may obtain a free copy of the Registration Statement and other documents that the combined company files with the SEC (when available) from the SEC's website at www.sec.gov or at investors.barinthusbio.com.

**<u>Participants in the Solicitation</u>**

Clywedog Therapeutics Inc. ("Clywedog"), the Company and their respective directors, executive officers, other members of management, certain employees and other persons may be deemed to be participants in the solicitation of proxies from the security holders of the Company in connection with the proposed transaction. Security holders may obtain information regarding the names, affiliations and interests of the Company's directors and executive officers in the Registration Statement. To the extent holdings of the Company's securities by the Company's directors and executive officers have changed since the amounts set forth in the Registration Statement , such changes have been or will be reflected on subsequent Statements of Changes in Beneficial Ownership on Form 4 filed with the SEC. Additional information regarding the interests of such individuals in the proposed transaction is included in the Registration Statement. These documents (when available) may be obtained free of charge from the SEC's website at www.sec.gov and the Company's website at investors.barinthusbio.com.

**<u>No Offer or Solicitation</u>**

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This press release is not intended to and shall not constitute an offer to buy or sell or the solicitation of an offer to buy or sell any securities, nor shall there be any offer, solicitation or sale of securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction. No offering of securities shall be made except by means of a prospectus meeting the requirements of Section 10 of the Securities Act of 1933, as amended, and otherwise in accordance with applicable law.

**Item 9.01. Financial Statements and Exhibits.**

(d)Exhibits

---

| | |
|:---|:---|
| <u>[99.1](brns-20260331xexx991.htm)</u> | <u>[Press Release dated April 30, 2026.](brns-20260331xexx991.htm)</u> |
| 104 | Cover Page Interactive Data File (embedded within the Inline XBRL document). |

---

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**SIGNATURE**

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

---

| | | |
|:---|:---|:---|
| | Barinthus Biotherapeutics plc | Barinthus Biotherapeutics plc |
| Date: April 30, 2026 | By: | /s/ William Enright |
|  |  | William Enright |
|  |  | Chief Executive Officer |

---

## Exhibit 99.1

![a1a.jpg](a1a.jpg)

**Barinthus Bio Reports First Quarter 2026 Financial Results and Updates on Corporate Developments**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;*• Proposed combination with Clywedog Therapeutics Inc. ("Clywedog") progressing towards closing which will result in a differentiated company focusing on metabolic and autoimmune pipeline assets with multiple important clinical development milestones in the 18 months after closing*

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;*• Multiple ascending dose part of the Phase 1 AVALON trial of VTP-1000 in celiac disease patients is progressing; data expected in the second half of 2026*

GERMANTOWN, Maryland, April 30, 2026 (GLOBE NEWSWIRE) – Barinthus Biotherapeutics plc (NASDAQ: BRNS) ("Barinthus Bio," or the "Company"), today announced its financial results for the quarter ended March 31, 2026, and provided an overview of the Company's corporate developments. Barinthus Bio is an immunology and inflammation ("I&I") company focused on developing therapies that promote immune tolerance with curative potential.

"As we complete the first quarter of 2026, our focus remains on advancing the proposed combination with Clywedog, which we believe represents a transformative opportunity for Barinthus Bio by creating a compelling and differentiated pipeline focused on autoimmune and metabolic diseases," said Bill Enright, Chief Executive Officer of Barinthus Bio. "Throughout the first quarter, we continued to advance the activities necessary to complete the transaction, while also preparing for a seamless integration following closing. At the same time, our major focus is to progress the ongoing clinical development of our core asset, VTP-1000, in celiac disease. With encouraging single ascending dose data in hand from the Phase I AVALON trial and multiple ascending dose data expected in the second half of 2026, we see a clear opportunity for VTP-1000 to deliver near-term clinical milestones and to contribute to long-term shareholder value for the combined company."

**Recent Corporate Developments**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Doug Swirsky, seasoned biotechnology executive with public company CFO experience, has been appointed to serve as the Chief Financial Officer effective May 1, 2026.

**Upcoming Milestones** 

*Celiac Disease (VTP-1000):* 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Data from the multiple ascending dose portion of the Phase 1 AVALON clinical trial, which includes a gluten challenge following three doses of test medication, is expected in the second half of 2026.

&nbsp;&nbsp;&nbsp;&nbsp;

*Corporate:* 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• Barinthus Bio expects to complete the merger with Clywedog mid-2026. Upon the closing of the transaction, the combined company will be renamed "Clywedog Therapeutics Holdings, Inc." and is expected to trade on the NASDAQ under the new ticker symbol "CLYD." The combined company's estimated cash runway is expected to extend through 2027, supported by existing cash and additional investments by OrbiMed and TPAV, LLC, both existing shareholders in Clywedog, and new investors.

 **First Quarter 2026 Financial Highlights**

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• **Cash:** As of March 31, 2026, cash, cash equivalents and restricted cash were $67.2 million, compared to $71.9 million as of December 31, 2025. The $4.7 million decrease was a result of the net cash used in operating activities of which $3.4 million was used for the development of the Company's pipeline and general corporate expenses, and a $1.4 million translational loss from the conversion of balances in pound sterling denominated entities to the United States dollar reporting currency. Based on standalone research and development plans, the Company expects its available resources to fund its operating expenses and capital expenditure requirements for at least the next 12 months from the date of issuance of the financial statements.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**• Research and Development Expenses:** Research and development expenses were $3.6 million for the three months ended March 31, 2026 compared to $8.3 million for the three months ended March 31, 2025. The decrease was primarily attributable to reduced activity in the Barinthus legacy asset clinical programs and the reduction in

------

workforce. The quarter-on-quarter research and development expenses are outlined in the following table, with the expense primarily attributable to the continued progression of the Phase 1 AVALON clinical trial of VTP-1000 in celiac disease, and the reduced activity on legacy assets in infectious disease and oncology. It is anticipated that research and development expenses related to the Barinthus legacy assets in infectious disease and oncology will continue to decrease going forward as the clinical trials complete, and that research and development expenses related to autoimmune program will continue at current levels or increase, as the clinical development continues.

---

| | | | |
|:---|:---|:---|:---|
| | **Three months ended March 31, 2026** | **Three months ended March 31, 2025** | **Change** |
| | **$000** | **$000** | **$000** |
| Direct research and development expenses by program: |  |  |  |
| &nbsp;&nbsp;VTP-1000 Celiac | $1422 | $982 | $440 |
| &nbsp;&nbsp;Barinthus legacy assets<sup>1</sup> | 1480 | 2510 | (1030) |
| Total direct research and development expenses | 2902 | 3492 | (590) |
| Indirect research and development expenses: |  |  |  |
| &nbsp;&nbsp;Personnel-related (including share-based compensation) | 503 | 3944 | (3441) |
| &nbsp;&nbsp;Facility related | 87 | 335 | (248) |
| &nbsp;&nbsp;Other indirect costs | 101 | 519 | (418) |
| Total indirect research and development expenses | 691 | 4798 | (4107) |
| Total research and development expense | $3593 | $8290 | $(4697) |

---

<sup>1</sup> In January 2025, we announced a strategic focus on developing a pipeline in I&I, and the deprioritization of our programs in infectious disease and oncology. The following programs were previously presented separately and have been grouped collectively as "Barinthus Legacy Assets" for both years presented: VTP-300 HBV, VTP-850 Prostate Cancer, VTP-200 HPV, VTP-600 NSCLC, VTP-500 MERS and other and earlier stage programs.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;• **General and Administrative Expenses:** General and administrative expenses were $2.5 million in the first quarter of 2026, compared to $12.6 million in 2025. The decrease of $10.1 million related primarily to an decrease in unrealized losses on foreign exchange driven mainly by translation of United States dollar balances in pound sterling denominated entities and an increase in professional fees attributable to strategic activity, partially offset by decreases in personnel-related expenses and other costs following the strategic prioritization in the prior year.

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;**• Net Loss:** For the first quarter of 2026, the Company generated a net loss attributable to its shareholders of $5.5 million, or $(0.14) per share on both basic and fully diluted bases, compared to a net loss attributable to its shareholders of $19.6 million, or $(0.49) per share on both basic and fully diluted bases for the first quarter of 2025.

------

**About Barinthus Bio**

Barinthus Biotherapeutics (NASDAQ: BRNS) is a clinical-stage biopharmaceutical company developing novel immunotherapeutic candidates designed to guide the immune system to overcome autoimmunity and chronic infectious diseases. Helping people and their families living with serious diseases is the guiding principle at the heart of Barinthus Bio. With a focused pipeline built around its proprietary platform technologies, Barinthus Bio is advancing immunotherapeutic product candidates in autoimmunity including: VTP-1000, which utilizes the Company's SNAP-Tolerance Immunotherapy (SNAP-TI) platform and is designed to treat people with celiac disease. Barinthus Bio's differentiated technology platform and therapeutic approach, coupled with deep scientific expertise and focus on clinical development, positions the Company to navigate towards delivering treatments that improve the lives of people with autoimmunity. For more information, visit www.barinthusbio.com.

**Forward Looking Statements**

This press release contains forward-looking statements regarding Barinthus Bio within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, which can generally be identified as such by use of the words "may," "will," "plan," "forward," "encouraging," "believe," "potential," "expect," and similar expressions, although not all forward-looking statements contain these identifying words. These forward-looking statements include, without limitation, express or implied statements regarding future expectations, plans and prospects, including product development activities and clinical trials, including timing for readouts of any preliminary, interim or final data for any of our programs, the Company's cash runway and cash burn, the Company's ability to develop and advance current and future product candidates and programs,the Company's ability to establish and maintain collaborations or strategic relationships, the proposed transaction with Clywedog, the expected timing of the closing of the proposed transaction, the ability of the parties to complete the proposed transaction considering the various closing conditions, the expected benefits of the proposed transaction, the competitive ability and position of the combined company after completion of the proposed transaction, the anticipated impact of the proposed transaction on the combined company's business and future financial and operating results, including without limitation the expected cash runway of the combined company, and the expected or estimated amount, achievability, sources, impact and timing of cost synergies and revenue, growth, operational enhancement, expansion and other value creation opportunities from the proposed transaction. Any forward-looking statements in this press release are based on management's current expectations and beliefs and are subject to numerous risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, risks and uncertainties related to the success, cost and timing of the Company's pipeline development activities and planned and ongoing clinical trials, including the risk that the timing for preliminary, interim or final data or initiation of clinical trials may be delayed, the risk that interim or topline data may not reflect final data or results, the Company's ability to execute on strategy, regulatory developments, the risk that the Company may not achieve the anticipated benefits of our pipeline prioritization and corporate restructuring, the Company's ability to fund its operations and access capital, the Company's cash runway, including the risk that the estimate of the cash runway may be incorrect, the risk that the proposed transaction may not be completed in a timely manner or at all, which may adversely affect our business and the price of our securities, the risk that that the proposed transaction may involve unexpected costs, liabilities or delays, or divert management's attention from our ongoing business operations, the risk of any legal proceedings related to the proposed transaction or otherwise, or the impact of the proposed transaction thereupon, the risk that the anticipated benefits of the proposed transaction may otherwise not be fully realized or may take longer to realize than expected, risks relating to the value of the combined company securities to be issued in the proposed transaction, the risks associated with global economic uncertainty, including disruptions in the banking industry, the conflicts in Ukraine, Iran, Israel and Gaza, the disruptions in U.S. federal government operations, tariffs imposed by the U.S. and other countries, and the other risks identified in the Company's filings with the Securities and Exchange Commission (the "SEC"), including the Company's most recent annual report on Form 10-K and subsequent filings the Company may make with the SEC. The Company cautions you not to place undue reliance on any forward-looking statements, which speak only as of the date they are made. The Company expressly disclaims any obligation to publicly update or revise any such statements to reflect any change in expectations or in events, conditions or circumstances on which any such statements may be based, or that may affect the likelihood that actual results will differ from those set forth in the forward-looking statements.

**Additional Information and Where to Find It**

In connection with the proposed transaction, the combined company has filed with the SEC and mailed or otherwise provided to Barinthus Bio's investors and security holders a registration statement on Form S-4 that contains a joint proxy statement/prospectus (the "Registration Statement"). BARINTHUS BIO'S INVESTORS AND SECURITY HOLDERS

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ARE URGED TO CAREFULLY READ THE REGISTRATION STATEMENT IN ITS ENTIRETY AND ANY OTHER DOCUMENTS FILED OR THAT WILL BE FILED BY BARINTHUS BIO WITH THE SEC IN CONNECTION WITH THE PROPOSED TRANSACTION OR INCORPORATED BY REFERENCE THEREIN BECAUSE THEY CONTAIN OR WILL CONTAIN IMPORTANT INFORMATION ABOUT THE PROPOSED TRANSACTION AND THE PARTIES TO THE PROPOSED TRANSACTION.

Investors and security holders may obtain a free copy of the Registration Statement and other documents that the combined company files with the SEC (when available) from the SEC's website at www.sec.gov or at investors.barinthusbio.com.

**No Offer or Solicitation**

This press release is not intended to and shall not constitute an offer to buy or sell or the solicitation of an offer to buy or sell any securities, nor shall there be any offer, solicitation or sale of securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction. No offering of securities shall be made except by means of a prospectus meeting the requirements of Section 10 of the Securities Act of 1933, as amended, and otherwise in accordance with applicable law.

**Participants in the Solicitation**

Clywedog, Barinthus Bio and their respective directors, executive officers, other members of management, certain employees and other persons may be deemed to be participants in the solicitation of proxies from the security holders of Barinthus Bio in connection with the proposed transaction. Security holders may obtain information regarding the names, affiliations and interests of Barinthus Bio's directors and executive officers in Registration Statement. To the extent holdings of Barinthus Bio's securities by Barinthus Bio's directors and executive officers have changed since the amounts set forth in the Registration Statement, such changes have been or will be reflected on subsequent Statements of Changes in Beneficial Ownership on Form 4 filed with the SEC. Additional information regarding the interests of such individuals in the proposed transaction is included in the Registration Statement. These documents (when available) may be obtained free of charge from the SEC's website at www.sec.gov and Barinthus Bio's website at investors.barinthusbio.com.

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**BARINTHUS BIOTHERAPEUTICS PLC** 

**CONSOLIDATED BALANCE SHEETS** 

**(IN THOUSANDS, EXCEPT NUMBER OF SHARES AND PER SHARE AMOUNTS)** 

**(UNAUDITED)**

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| | | |
|:---|:---|:---|
| | **As of<br>March 31,<br>2026** | **As of<br>December 31,<br>2025** |
| **ASSETS** | | |
| &nbsp;&nbsp;&nbsp;Cash and cash equivalents | $65858 | $70456 |
| &nbsp;&nbsp;&nbsp;Restricted cash | 1331 | 1396 |
| &nbsp;&nbsp;&nbsp;Research and development incentives receivable | 1232 | 1108 |
| &nbsp;&nbsp;&nbsp;Prepaid expenses and other current assets | 4243 | 4830 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total current assets | 72664 | 77790 |
| &nbsp;&nbsp;&nbsp;Property and equipment, net | 3270 | 3523 |
| &nbsp;&nbsp;&nbsp;Intangible assets, net | 13666 | 14288 |
| &nbsp;&nbsp;&nbsp;Right of use assets, net | 1629 | 1638 |
| &nbsp;&nbsp;&nbsp;Other assets | 914 | 930 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total assets | $92143 | $98169 |
| **LIABILITIES AND STOCKHOLDERS' EQUITY** |  |  |
| Current liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;Accounts payable | 993 | 350 |
| &nbsp;&nbsp;&nbsp;Accrued expenses and other current liabilities | 8685 | 6249 |
| &nbsp;&nbsp;&nbsp;Deferred income | 318 | 1396 |
| &nbsp;&nbsp;&nbsp;Operating lease liability - current | 2005 | 2023 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total current liabilities | 12001 | 10018 |
| Non-current liabilities: |  |  |
| &nbsp;&nbsp;&nbsp;Operating lease liability - non-current | 9003 | 9258 |
| &nbsp;&nbsp;&nbsp;Contingent consideration | 2956 | 2871 |
| &nbsp;&nbsp;&nbsp;Other non-current liabilities | 1468 | 1476 |
| &nbsp;&nbsp;&nbsp;Deferred tax liability, net | 237 | 254 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total liabilities | $25665 | $23877 |
| Commitments and contingencies (Note 16) |  |  |
| Stockholders' equity: |  |  |
| &nbsp;&nbsp;&nbsp;Ordinary shares, £0.000025 nominal value; 40,848,893 shares authorized, issued and outstanding (December 31, 2025: authorized, issued and outstanding: 40,848,893) | 1 | 1 |
| &nbsp;&nbsp;&nbsp;Deferred A shares, £1 nominal value; 63,443 shares authorized, issued and outstanding (December 31, 2025: authorized, issued and outstanding: 63,443) | 86 | 86 |
| &nbsp;&nbsp;&nbsp;&nbsp;Additional paid-in capital | 394499 | 393944 |
| &nbsp;&nbsp;&nbsp;&nbsp;Accumulated deficit | (309628) | (304092) |
| &nbsp;&nbsp;&nbsp;&nbsp;Accumulated other comprehensive loss – foreign currency translation adjustments | (18559) | (15731) |
| &nbsp;&nbsp;&nbsp;&nbsp;Total stockholders' equity attributable to Barinthus Biotherapeutics plc shareholders | 66399 | 74208 |
| &nbsp;&nbsp;&nbsp;&nbsp;Noncontrolling interest | 79 | 84 |
| &nbsp;&nbsp;&nbsp;&nbsp;Total stockholders' equity | $66478 | $74292 |
| Total liabilities and stockholders' equity | $92143 | $98169 |

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**BARINTHUS BIOTHERAPEUTICS PLC** 

**CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS** 

**(IN THOUSANDS, EXCEPT NUMBER OF SHARES AND PER SHARE AMOUNTS)** 

**(UNAUDITED)**

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| | | |
|:---|:---|:---|
| | **Three months ended** | **Three months ended** |
| | **March 31, 2026** | **March 31, 2025** |
| Operating expenses |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Research and development | $3593 | $8290 |
| &nbsp;&nbsp;&nbsp;&nbsp;General and administrative | 2528 | 12639 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total operating expenses | 6121 | 20929 |
| Other operating income/(expense) | 46 | 329 |
| Loss from operations | (6075) | (20600) |
| Other income/(expense): |  |  |
| &nbsp;&nbsp;&nbsp;&nbsp;Interest income | 350 | 556 |
| &nbsp;&nbsp;&nbsp;&nbsp;Interest expense | (13) | (13) |
| &nbsp;&nbsp;&nbsp;&nbsp;Research and development incentives | 149 | 302 |
| &nbsp;&nbsp;&nbsp;&nbsp;Other income | 39 | 75 |
| &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total other income, net | 525 | 920 |
| Loss before income tax | (5550) | (19680) |
| Tax benefit | 16 | 22 |
| Net loss | (5534) | (19658) |
| &nbsp;&nbsp;&nbsp;&nbsp;Net loss attributable to noncontrolling interest | 3 | 10 |
| Net loss attributable to Barinthus Biotherapeutics plc shareholders | (5531) | (19648) |
| Weighted-average ordinary shares outstanding, basic | 40848893 | 40265216 |
| Weighted-average ordinary shares outstanding, diluted | 40848893 | 40265216 |
| Net loss per share attributable to ordinary shareholders, basic | $(0.14) | $(0.49) |
| Net loss per share attributable to ordinary shareholders, diluted | $(0.14) | $(0.49) |
| Net loss | $(5534) | $(19658) |
| Other comprehensive (loss)/gain – foreign currency translation adjustments | (2836) | 4646 |
| Comprehensive loss | (8370) | (15012) |
| Comprehensive loss attributable to noncontrolling interest | 5 | 7 |
| Comprehensive loss attributable to Barinthus Biotherapeutics plc shareholders | $(8365) | $(15005) |

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**Company contact:**

<u>ir@barinthusbio.com</u>

<br>